anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The prevalence of dementia in rural areas is higher than in urban areas. However, the resource and research input on cognitive training for rural older adults still needs improvement. There is also no solution for preventing or early detection of dementia in rural areas. Unlike biomarkers that require invasive detection, digital biomarkers have been advocated in recent years for early disease prediction. However, there are still few studies on the effectiveness of digital biomarkers in evaluating cognitive function in the elderly. In addition, although previous studies have confirmed that cognitive training can be effective for older adults, it is difficult for the elderly in rural areas to obtain these cognitive-promoting resources due to distance. Moreover, the autonomy and right of choice of older adults are the keys to the success of their health behavior change.
Medicinal tablets, intended to dissolve only on reaching a predetermined part of the digestive tract, are coated with a water-insoluble and indigestable base composition having incorporated therein an agent which, when acted upon by moisture, expands or is effervescent so as to disrupt the coating.  Bases specified are stearic acid, carnauba wax, petroleum jelly, mixtures of these three substances, hydrogenated vegetable oil, shellac, cellulose products such as nitro cellulose lacquer or a solution of celluloid in methyl acetone or solutions such as are used for preparing "Cellophane" (Registered Trade Mark), gum mastic, and gum benzoin.  Substances causing disintegration of the coating are agar, powdered elm, cinnamon bark, corn-meal, thyme, kaolin, and mixtures of tartaric acid with sodium bicarbonate. Choice of particular bases and of the added ingredients and the proportions in which they are mixed permit the period between ingestion and disruption of the coating to be varied.  According to one example, agar is mixed with a melted base consisting of carnauba wax, petroleum jelly and stearic acid.  The tablets may be coated by dipping, or the mixture may be allowed to set, pulverized and applied, in a rolling pan to tablets which have been coated with an adhesive such as shellac.  More than one such coating may be applied and the coated tablets may be used directly, or may be passed under a flame to seal them by fusing the surface of the coating.  In other methods, the tablets are coated with shellac and rolled in a pan with powdered agar, or are dipped in a solution of celluloid in methyl acetone to which tartaric acid and sodium bicarbonate have been added.  Reference has been directed by the Comptroller to Specification 427,106,
DACL worn first, followed by MDACL, as randomized. Each product worn bilaterally for approximately 1 week in a daily disposable modality.
A gel for treating tooth anaphylactia and an occlusion facing are disclosed. Said gel is prepared from Chinese-medicinal materials through special process and has no any toxic by-effect. Said occlusion facing is made up of the elastic material of soft resin and has a medicine storage cavoty. When said facing is applied in oral cavity, the medicine can durably and effectively act on the tooth to be treated. Said facing is tightly close to the other part of oral cavit, so isolating the medicine from it. Its advantages are high safety, reliability and curative rate, and convenient application.
PROBLEM TO BE SOLVED: To obtain an emulsion high in emulsion stability and good in use feeling, in a composite emulsion wherein an O/W type emulsion is dispersed in an outer oil phase, by adding org. modified clay mineral to the outer oil phase and adding a silicone-based oil component to the oil phase. SOLUTION: In this composite emulsion, org. modified clay mineral 20 is oriented at the boundary surface of an aq. phase 12 and an outer oil phase 10 and an inner oil phase 14 and the outer oil phase 10 are structurally and physically isolated by the org. modified clay mineral 20. As a result, it can be effectively prevented that the inner oil phase 14 is united with the outer oil phase 10. For example, if an oil soluble chemical agent hardly soluble in a silicone oil component and polar oil high in the solubility of this oil soluble chemical agent is compounded with the inner oil phase 14 and the silicone-based oil component is compounded with the outer oil phase 10, the crystallization of the oil soluble chemical agent can be prevented, while both of them are allowed to coexist in one emulsion system.  This emulsion has a use feeling good in spreadability and generate no stickiness and is high in emulsion stability.
These children will undergo the intervention (delayed leg training) after a delay of \~3 months, during which outcome measures will be taken so that they can serve as a control for the early treatment group. Their intervention is identical to the Immediate treatment group.
No data collected from these nursing homes for one year since baseline. They receive INTERACT training starting on MAR 2014.
PURPOSE: A smoking cessation using peaches and a manufacturing method thereof are provided to be used for all ages regardless of sex and to be used as snacks. CONSTITUTION: A smoking cessation using peaches comprises 50 wt% of dried peach, 10 wt% of glycyrrhizae radix, 20 wt% of black soybean, and 20 wt% of glutinous rice. A manufacturing method of the smoking cessation using peaches comprises the following steps: grinding 50 wt% of dried peach, 10 wt% of glycyrrhizae radix, 20 wt% of black soybean, and 20 wt% of glutinous rice and making into powder(s11); additional mixing cinnamomi cortex and water at a ratio of 20 liters of water per 500g of the cinnamomi cortex for 1 to 2 hours(s12); mixing the water in which cinnamon taste is brewed with the powder from the first step and predetermined amount of flour; and kneading thereof(s13). The manufacturing method additionally includes steps of preparing the dough material into tablets and drying in the shaded area(s14). The smoking cessation is chewing gum, snack or drink. [Reference numerals] (S11) Material grinding step; (S12) Additional mixing and boiling of materials; (S13) Kneading step; (S14) Preparing the dough material into tablets and drying thereof
A 16-week center-based PRT intervention (PRT-C) consisting of 12 hours per week including 1 hour of parent training. This intervention targets social communication deficits.
Atrial fibrillation (AF) is a heart rhythm disorder in which the normal beating in the upper chambers of the heart is irregular, leading to poor blood flow to the lower chambers. Risk factors include older age, high blood pressure, obesity, European ancestry, diabetes, heart failure, ischemic heart disease, hyperthyroidism, chronic kidney disease, heavy alcohol use, and enlarged heart chambers on the left side \[3\]. AF increases a person's risk for stroke and contributes to an estimated 130,000 deaths each year \[1\]. Treatment generally includes medication, surgery, and/or healthy lifestyle changes \[1\]. Electrical cardioversion, in which the patient must undergo sedation or general anesthesia, is also used to convert patients with persistent AF to normal sinus rhythm. Electrical cardioversion has been associated with a high initial success rate of 68-98% \[4\], but long-term maintenance of sinus rhythm has proved challenging \[5\]. Due to the potential risks incurred to the patient, it is important to understand which patients are good candidates for cardioversion therapy. A review article describes that duration of AF, sex, age, weight smoking status, number of shocks at cardioversion, post-ablation procedure, medications, hypertension, diabetes, Chronic Obstructive Pulmonary Disease (COPD), obstructive sleep apnea, renal impairment, hyperthyroidism, coronary artery disease, congestive heart failure, left systolic dysfunction, left diastolic dysfunction, left ventricular hypertrophy, valvular heart disease, and left atrial size have each been found to be associated with maintenance of sinus rhythm \[6\].

Echocardiography has been increasing used in understanding the cardiac structure and risk of stroke among patients with AF, with left atrial size, left ventricular wall thickness, and left ventricular dysfunction recognized as independent predictors of AF \[7\]. Increasing evidence supports that the left atrial strain measurements can be a predictor of outcomes among AF patients, including stroke and AF recurrence after catheter ablation \[8\], \[9\]. The investigators aim to further explore left atrial strain measurements, including left atrial global longitudinal strain (LA GLS), as predictors of maintenance of normal sinus rhythm post- cardioversion. It is anticipated that a lower LA GLS will predict AF recurrence. To do this, the investigators will study patients with AF at Pen Bay Medical Center who have undergone cardioversion, measuring their LA GLS pre-cardioversion, and assess maintenance of sinus rhythm 6 months post-cardioversion. It is anticipated that this study will confirm LA GLS as a marker for maintenance of sinus rhythm post-cardioversion.
BACKGROUND: Mozambique is one of the countries in Africa that is continuously at risk of cholera outbreaks due to poor sanitation, hygiene, and limited access to potable water in some districts. The Mozambique Cholera Prevention and Surveillance (MOCA) project was implemented in Cuamba District, Niassa Province to prevent and control cholera outbreaks through a preemptive cholera vaccination, strengthened surveillance system for cholera and diarrheal diseases, and better understanding of cholera-related healthcare seeking behavior of local populations, which may further guide the national cholera control and prevention strategies. This article presents the surveillance component of the MOCA project.
METHODOLOGY/PRINCIPAL FINDINGS: A prospective healthcare facility (HCF)-based surveillance of cholera and diarrheal disease was conducted in six HCFs in the District of Cuamba from March 2019 to December 2020. A systematic surveillance procedure has been put in place with capacity building in selected sentinel HCFs and a basic microbiology laboratory established on-site. Patients presenting with suspected cholera or other diarrheal symptoms were eligible for enrollment. Clinical data and rectal swab samples were collected for laboratory confirmation of Vibrio Cholerae and other pathogens. A total of 419 eligible patients from six HCFs were enrolled. The median age was 19.8 years with a similar age distribution between sentinel sites. The majority were patients who exhibited diarrhea symptoms not suspected of cholera (88.8%; n = 410). Among those, 59.2% (210/397) were female and 59.9% (235/392) were 15 years and above. There were 2 cholera cases, coming outside of the catchment area. The incidence of diarrheal diseases ranged from 40-103 per 100,000 population. No Vibrio cholerae was isolated among surveillance catchment population and Escherichia coli spp. (82/277; 29.6%) was the most common pathogen isolated.
CONCLUSION/SIGNIFICANCE: Efforts were made to strengthen the systematic surveillance of suspected cholera with standardised patient screening, enrolment, and diagnostics. The first basic microbiology laboratory in Niassa Province established in Cuamba District under the MOCA project needs to be integrated into the national network of laboratories for sustainability. No reports of laboratory confirmed cholera cases from the surveillance catchment area may be highly related to the pre-emptive oral cholera vaccine (OCV) mass vaccination campaign conducted in 2018 and the use of drugs by local populations prior to visiting the sentinel HCFs. Continued systematic cholera surveillance is needed to closely monitor the cholera endemicity and epidemics, and further evaluate the long-term impact of this vaccination. High incidence of diarrheal illnesses needs to be addressed with improved water, sanitation, and hygiene (WaSH) conditions in Cuamba District. Efforts integrated with the prioritization of prevention measures are fundamental for the control of cholera in the country.
Inflammation within the brain is a hallmark of a wide range of brain diseases. The complex role of inflammatory processes in these conditions suggests that neuroinflammation could be a valuable therapeutic target. While several promising anti-inflammatory agents have been identified, their clinical application in brain diseases is often hampered by the inability to cross the blood-brain barrier (BBB) and reach therapeutically effective concentrations at the pathological sites. This limitation highlights the urgent need for effective BBB-penetrating drug delivery systems designed to target brain inflammation. This review critically examines the recent advances over the past five years in drug delivery strategies aimed at mitigating brain inflammation in Alzheimer's disease and ischemic stroke─two of the leading causes of death and disability worldwide. Additionally, we address the key challenges in this field, offering insights into future directions for targeting neuroinflammation in the treatment of brain diseases.
There are two phases of study treatment. Phase I includes all patients and will last 6 weeks. During this phase, oxaliplatin will be given intravenously (IV) on days 1, 8, 22, and 29; bevacizumab will be given IV on days 1, 15, and 29; capecitabine will be administered orally on days 1-14 and 22-35. Radiation therapy will be given once daily for 5 days (Monday-Friday) per week for a total of 28 treatments. Phase II has two groups: 1) patients who had tumors removed prior to entering study and 2) patients who entered the study with advanced disease. Patients who had their tumors removed prior to entering the study will be treated with the above 6-week regimen twice for a total of 12 weeks of treatment. Patients who were unresectable prior to entering the study but then were deemed resectable after treatment on trial will undergo resection. Following surgical recovery (8-10 weeks) they will be treated again with the above 6-week regimen twice for a total of 12 weeks of treatment.
NEW MATERIAL:The isocarbostyryl derivative of formula I (R is H, lower alkyl, lower alkoxy or halogen; A is lower alkylene; n is 0 or 1-3) or its salt. EXAMPLE:6-{ 3-[ 4-( 3-Chlorophenyl )-1-piperazinyl ]propoxy }-3,4-dihydroisocarbostyrl. USE:It has antihistaminic and central nervous system depressing activities, and is useful as an antihistaminic agent and central nervous depressant. For example, it is used as a remedy for allergic symptom, or as a hypnotic, hypotensor, etc. PROCESS:The compound of formula I can be prepared, e.g. by reacting the halogenoalkoxyisocarbostyryl derivative of formula II (X is halogen) with the piperazine derivative of formula III preferably in the presence of a basic compound as a dehydrohalogenation agent, at room temperature - 200 deg.C, preferably 60- 120 deg.C.
Bioinformatics has emerged as a valuable tool for screening drugs and understanding their effects. This systematic review aimed to evaluate whether in silico studies using anti-obesity peptides targeting therapeutic pathways for obesity, when subsequently evaluated in vitro and in vivo, demonstrated effects consistent with those predicted in the computational analysis. The review was framed by the question: "What peptides or proteins have been used to treat obesity in in silico studies?" and structured according to the acronym PECo. The systematic review protocol was developed and registered in PROSPERO (CRD42022355540) in accordance with the PRISMA-P, and all stages of the review adhered to these guidelines. Studies were sourced from the following databases: PubMed, ScienceDirect, Scopus, Web of Science, Virtual Heath Library, and EMBASE. The search strategies resulted in 1015 articles, of which, based on the exclusion and inclusion criteria, 7 were included in this systematic review. The anti-obesity peptides identified originated from various sources including bovine alpha-lactalbumin from cocoa seed (Theobroma cacao L.), chia seed (Salvia hispanica L.), rice bran (Oryza sativa), sesame (Sesamum indicum L.), sea buckthorn seed flour (Hippophae rhamnoides), and adzuki beans (Vigna angularis). All articles underwent in vitro and in vivo reassessment and used molecular docking methodology in their in silico studies. Among the studies included in the review, 46.15% were classified as having an "uncertain risk of bias" in six of the thirteen criteria evaluated. The primary target investigated was pancreatic lipase (n = 5), with all peptides targeting this enzyme demonstrating inhibition, a finding supported both in vitro and in vivo. Additionally, other peptides were identified as PPARγ and PPARα agonists (n = 2). Notably, all peptides exhibited different mechanisms of action in lipid metabolism and adipogenesis. The findings of this systematic review underscore the effectiveness of computational simulation as a screening tool, providing crucial insights and guiding in vitro and in vivo investigations for the discovery of novel anti-obesity peptides.
Open the peritoneum proceeds cephalad towards the duodenojejunal angle of Treitz, and the mesenteric root is incised 1 cm below the inferior margin of the pancreas. The aortomesenteric window is opened wide and the inferior mesenteric vessels are exposed. The IMA is ligated and divided at 2 cm from its origin. The inferior mesenteric vein (IMV) is divided and ligated below the pancreatic margin.
PROBLEM TO BE SOLVED: To provide an ultraviolet absorber which has a high water solubility and does not exhibit absorption in the visible range by using a pyrimidine derivative or its salt as the main ingredient. SOLUTION: A pyrimidine derivative of the formula or its salt is used as the main ingredient. In the formula, R1 to R3 are each H, CH3 or C2H5, preferably H or CH3; still preferably, R1 and R3 are each CH3 and R2 is H. This ultraviolet absorber has an excellent ultraviolet-absorption capability in the region of ultraviolet wavelengths and has high stability and safeness. Salts of inorganic acids, such as hydrochloric, sulfuric, phosphoric, and hydrobromic acids, and salts of organic acids, such as acetic, lactic, maleic, fumaric, tartaric, and citric acids, are listed as the salts, a hydrochloride being preferable. Preferably, the absorber is compounded into a skin external preparation; in this case, the absorber does not cause discoloration even when compounded together with an inorganic powder and thus can be used together with an inorganic powder.  A pyrimidine derivative can be synthesized by the cyclocondensation of urea and a 1,3-dicarbonyl compound such as acetylacetone.
Cohort A will include participants with a glioblastoma tumor with an unmethylated MGMT promoter. Participants will receive INO-5401 and INO-9012 and cemiplimab as well as radiation and temozolomide (TMZ; only during radiation therapy), if clinically indicated.
Raspberry, a traditional medicine food homology species, has important benefits in patients with metabolic syndrome. However, the mechanism of raspberry polysaccharides (RP) on obesity remains unclear. In our study, we showed that RP intervention is negatively associated with body weight gain, hyperlipidemia, inflammation, and fat accumulation in obese mice. RP ameliorated HFD-induced gut microbiota dysbiosis, produced short-chain fatty acids, maintained intestinal barrier integrity, and prevented metabolic endotoxemia, manifested by decreased host lipopolysaccharide level, and increased colon expression of tight junction proteins. These effects might be related with driven by a SCFAs-producing bacterium and downregulation of TLR4/NF-κB signaling transduction. Notably, the abundance of Ruminococcaceae_UCG - 014, Lactobacillus taiwanensis, Bifidobacterium pseudolongum, and Turicibacter are markedly correlated with enhanced intestinal barrier function induced by RP treatment. Thus, we believe that RP could be as a potential health supplement or prebiotic for obesity therapy.
Systems and methods for providing customizable sleeves for pill bottles, customizable adhesive attachments, customizable Post-it notes and methods for the manufacture thereof are provided. Also provided are methods of surveying pharmacists regarding the effect of customizable adhesive attachments to a pill bottle. The method may include using a digital computer to receive information relating to issues in implementation of a system for providing customizable adhesive attachments. The customizable adhesive attachments may be attached to the bottle. The adhesive attachments may be customizable with respect to at least two of 1) color; 2) content; and 3) texture. The method may further include using a digital computer to receive information relating to benefits obtained from the adhesive attachment.
Because diethylpropion hydrochloride tablets USP, 25 mg are monoamines, hypertension may result when either agent is used with monoamine oxidase (MAO) inhibitors (See CONTRAINDICATIONS). 

Efficacy of diethylpropion with other anorectic agents has not been studied and the combined use may have the potential for serious cardiac problems; therefore, the concomitant use with other anorectic agents is contraindicated.

Antidiabetic drug requirements (i.e., insulin) may be altered. Concurrent use with general anesthetics may result in arrhythmias. The pressor effects of diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, diethylpropion may interfere with antihypertensive drugs (i.e., guanethidine, a-methyldopa). Concurrent use of phenothiazines may antagonize the anorectic effect of diethylpropion.
BACKGROUND: Socioeconomic inequalities in the population influence access to health services and constitute a challenge for health systems, especially in low- and middle-income countries. In Peru, an increase in the use of medical services has been estimated; however, the study of inequalities in the use of medical services is limited. Therefore, the objective of this research was to analyze and decompose socioeconomic inequalities in the use of medical consultation services in Peru.
METHODS: A cross-sectional analytical study was conducted using data from the National Household Survey 2019. The outcome variable was the use of a consultation attended by a physician in the last 4 weeks in persons who presented symptom or discomfort, illness, relapse of chronic disease and/or accident. Concentration curves and Erreygers concentration indices were used to determine socioeconomic inequalities, and a generalized linear regression model was used for the decomposition analysis of inequalities.
RESULTS: A total of 52,715 persons were included in the study. The frequency of medical consultation was 25.4% (95% confidence interval: 24.8 - 26.1%). In the inequality analysis, it was found that the use of medical consultations was concentrated among the wealthiest individuals. The main contributing factors were having another type of health insurance (social health insurance [EsSalud], private health insurance, health provider, the Armed Forces, and the Police), residing in an urban area, belonging to the richest wealth quintile, having a chronic disease, and residing in the highlands of Peru.
CONCLUSIONS: Based on our findings, government institutions seeking to achieve equitable access to health services should consider the main factors contributing to this inequality in the formulation of strategies to lessen the negative impact of inadequate disease control in the population.