anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Melasma is an acquired and chronic disorder of hyperpigmentation characterized by symmetrical hypermelanoses of the face. The exact pathogenesis of melasma is still unknown. Several hormones are thought to play a role, including thyroid hormone. Although melasma is not life-threatening, it affects greatly on the quality of life of patients. Study's objectives are to determine proportion of melasma cases in hyperthyroid patients and to compare severity of melasma before and after medications of three months hyperthyroid therapy using mMASI score. An experimental (before and after) study was conducted in Jakarta in August 2019-February 2020. Twenty three newly-diagnosed hyperthyroid patients or had taken hyperthyroid medications of maximum 3 months with melasma were recruited. The severity of melasma were scored with mMASI and dermoscopy of the lesions were collected. The same procedures were done after 3 months of hyperthyroid therapy. The data collected was statistically analyzed using Stata version 15.0
The short-term safety and effectiveness of ZENPEP were assessed in 2 clinical studies in pediatric patients, ages 1 to 17 years, with EPI due to CF.

Study 1 was a randomized, double-blind, placebo-controlled, crossover study in 34 patients 26 of whom were children, including 8 children aged 7 to 11 years, and 18 adolescents aged 12 to 17 patients. The safety and efficacy in pediatric patients in this study were similar to adult patients [see Adverse Reactions (6.1) and Clinical Studies (14)].

Study 2 was an open-label, single arm study in 19 patients, ages 1 to 6 years, with EPI due to CF. When patient regimen was switched from their usual PEP regimen to ZENPEP at similar doses, patients showed similar control of their clinical symptoms.

The safety and efficacy of pancreatic enzyme products with different formulations of pancrelipase consisting of the same active ingredient (lipases, proteases, and amylases) for treatment of children with exocrine pancreatic insufficiency due to cystic fibrosis has been described in the medical literature and through clinical experience.

Dosing of pediatric patients should be in accordance with recommended guidance from the Cystic Fibrosis Foundation Consensus Conferences [see Dosage and Administration (2.1)]. Doses of other pancreatic enzyme products exceeding 6,000 lipase units/kg of body weight per meal have been associated with fibrosing colonopathy and colonic strictures in children less than 12 years of age [see Warnings and Precautions (5.1)].
Optimal dynamic analgesia is recognized as the key to enhanced recovery following open abdominal surgery. In the last decade, there has been a significant shift away from thoracic epidural analgesia (TEA) that has been long considered as the gold standard. Various techniques have tried to replicate the analgesic efficacy of TEA. They include transversus abdominis plane analgesia (TAP), rectus sheath analgesia (RS), wound infusion analgesia (WI) and trans muscular quadratus lumborum analgesia. However, each of these techniques has specific limitations that prevent them from being the analgesic technique of choice for all open abdominal surgeries. Chin et al first described the erector spinae plane (ESP) block for providing analgesia following ventral hernia repair. The unique feature of the ultrasound-guided truncal blocks is that in all of these techniques, in contrast to peripheral nerve blocks, no nerve or plexus needs to be identified: Local anesthesia (LA) is injected in a particular muscle plane, in which the injectate spreads and reaches the intended nerves. This simple mechanism has made delivery of nerve blocks easy and versatile.
Participants in this condition will receive daily a uniform daily goal of 10,000 steps per day. Participants will receive daily texts including information about the participant's steps on the previous day, whether they met their goal the previous day, and encouraging them to continue striving for 10,000 steps each day.
A method includes receiving first data based on a region of interest of tissue. The first data may be captured to represent the tissue according to a first moment. The method also includes receiving second data based on the region of interest. The second data may be captured to represent the tissue according to a second moment different from the first moment. The method also includes determining features of the first data according to a first network. The first network may comprise weights. The method also includes determining features of the second data according to the weights. The method also includes determining an input based on the features of the first data and the features of the second data. The method may also include treating a patient or adjusting treatment of the patient diagnosed by one or more of these steps. An apparatus for performing the method is disclosed.
The invention provides compositions and methods for treating neoplastic disease, such as cancer, with an oncolytic virus, such as VSV. A carrier cell is used to target a diseased tissue, and to cloak the oncolytic virus from surveillance by the subject's immune system during a targeting interval. Following delivery of the virus to the target tissue, the lysis of the carrier cell, and of the target cell, by the oncolytic virus, promotes an adaptive tumouricidal immune response. A wide variety of disparate carrier cells may be used, in conjunction with a promiscuous oncolytic virus having broad tropism, in an approach which facilitates successive treatments in which a new carrier will not be susceptible to an adaptive immune response mounted against previously used carriers. The promiscuity of the virus also facilitates lysis of carrier cells and target cells that are allogenic or xenogenic. The lytic phase of the carrier cell infection is staged so that the carrier is administered in an eclipse phase, and lysis follows the conclusion of the therapeutic targeting interval.
INTRODUCTION: Juvenile-onset Huntington's disease (JOHD) is characterized by a unique motor phenotype relative to patients with adult-onset Huntington's Disease (AOHD). This study characterized motor progression of JOHD to propose improved outcome measures for this group.
METHODS: We used linear mixed effect regression models to compare progression of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score (TMS) and the chorea score between patients with JOHD and AOHD. We then evaluated all 31 subscales that make up the UHDRS over time within patients with JOHD to identify measures that may be used to track motor progression most reliably.
RESULTS: The JOHD cohort had faster TMS progression compared to AOHD (p = 0.006) but no group difference in the rate of change of chorea. Patients with JOHD did not show significant change in any of the chorea subscales. The subscales that changed most reliably over time amongst patients with JOHD were dysarthria, upper extremity dystonia, tandem walking, gait, bilateral pronate/supinate, bilateral finger-tapping, and tongue protrusion. When these subscales were summed, they progressed at a faster rate (7.07%, 95% CI [5.96-8.18]) than the TMS (4.92%, 95% CI [3.95-5.89]).
CONCLUSION: While the TMS changes at a significant rate in JOHD subjects, not all subscales that make up the TMS accurately represent the unique motor features of JOHD. A JOHD-specific scale performed better at tracking motor progression relative to the TMS. This scale may improve clinical care for patients with JOHD and allow for the development of more efficient clinical trials.
BACKGROUND: The main purpose of national medical quality registries is to contribute to better patient treatment. The registries are also used in research and as management tools. The aim of the study was to investigate data quality in the Norwegian Myocardial Infarction Registry by comparing the proportion of correctly registered variables with a reference standard.
MATERIAL AND METHOD: A total of 641 myocardial infarction cases registered in the Norwegian Myocardial Infarction Registry in 2020 were randomly sampled from seven hospitals. Seven doctors - specialists in cardiovascular diseases or specialty registrars in cardiovascular diseases or internal medicine - reviewed the patient records and re-registered 23 registry variables for the sample. These new registrations constituted the reference standard. The variables were divided into three categories: categorical variables with and without interpretation of the text in the records and continuous variables for the time indications. We then calculated the proportion of correctly registered variables and response alternatives.
RESULTS: For variables retrieved from the patient record text without interpretation, 87 % to 100 % were correctly registered. For variables that were based on interpretations of the patient record text, the proportion that were correctly registered was lower: 20 % to 70 % for 'yes' for variables on clinical instability in non-ST-elevation myocardial infarction (NSTEMI), and 60 % for 'yes' for the variable 'myocardial infarction as complication'. The proportion of correctly registered time variables was 48 % to 100 %.
INTERPRETATION: The proportion of correctly registered variables was higher for categorical variables that could be retrieved without interpretation from the patient record text than for continuous time variables and categorical variables based on interpretations of the patient record text.
BACKGROUND: Leaving the patella unresurfaced in total knee arthroplasty (TKA) has increased significantly over the past decade in the United States, likely due to modern patella-friendly implants, complications with resurfacing, and the knowledge that historical studies were scientifically confounded. This study evaluated revision-free survivorship out to 8.5 years in a cohort of contemporary primary TKAs with patella-friendly femoral components and unresurfaced patellae.
METHODS: A total of 1,053 consecutive primary TKAs with unresurfaced patellae were retrospectively reviewed. A selective patellar nonresurfacing protocol was used for all cases. Kaplan-Meier survivorship estimates were calculated based on patellar revision and the latest follow-up. An aggressive lateral patellar facetectomy was performed in 78% (823 of 1,053) of cases. The cohort was 62% women and 43% American Society of Anesthesiologists physical status classification I or II with a mean age and body mass index of 65 years (range, 35 to 94) and 35 kg/m2 (range, 18 to 65), respectively.
RESULTS: A total of 4 (0.4%, 4 of 1,053) unresurfaced patellae were revised. Three were resurfaced as part of other procedures: 2 for global instability and one for aseptic loosening at a mean of 1.6 years; and one patella was resurfaced by an outside surgeon for unexplained pain. The all-cause revision-free survivorship estimate specifically related to the patella was 98.9% (95% confidence interval, 98 to 100) out to 8.5 years. No significant difference in survivorship was related to patellae with or without a lateral patellar facetectomy (99.5 versus 98.1%, P ≥ .191); however, 3 of 4 patellar revisions occurred in TKAs without a lateral patellar facetectomy (P = .035).
CONCLUSIONS: The results of this study demonstrate excellent revision-free survivorship related to unresurfaced patellae, particularly when a lateral facetectomy was performed. These early to midterm results using modern patella-friendly femoral components are promising and comparable to resurfaced patellae in the literature.
LEVEL OF EVIDENCE: IV.
The invention relates to the technical field of biological medicine, and particularly discloses a fusion protein and application thereof. The fusion protein consists of a polypeptide and 6 histidines, wherein the polypeptide has at least 9/10, 14/15 or 29/30 sequence identity with the amino acid sequence shown in SEQ ID NO. 1; 6 histidines are located at the C-terminus of the polypeptide. The fusion protein designed by the invention is derived from the protein of the human body, and the metabolic product is amino acid, so the fusion protein is better than other therapeutic drugs in safety. In addition, the fusion protein can obviously reduce the infarct volume of the brain of the tMCAO model mouse, has obvious treatment on ischemic cerebral apoplexy, and has longer treatment time window than the existing thrombolytic drugs. Compared with the existing cerebral arterial thrombosis therapeutic drug, the humanized sTREM2-6His fusion protein has a brand-new therapeutic action mechanism and target point.
An alternative route to moroidin-type bicyclic peptide biosynthesis is presented. Also included herein, it is reported that such moroidin-type bicyclic peptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) in plants. Whereas D. moroides and C. argentea entail a previously uncharacterized DUF2775 family protein as candidate precursor peptides for moroidin biosynthesis, Japanese kerria (Kerriajaponica) employs a BURP-domain protein as a precursor peptide similar to that of the recently reported lyciumin biosyntheti system. Disclosed herein are compositions and methods related to the biosynthesis of moroidin. In some embodiments of the disclosure, the moroidin peptides are synthetic. In other embodiments, the moroidin peptides are heterogenous. A skilled artisan will readily appreciate that based on the data disclosed herein that the present disclosure provides for the production of moroidins in transgenic host cells.
The investigators study is designed as a pilot study to study the effect of STS on urine chemistries in stone formers and normal controls. It is expected to continue for a duration of 1 year and will have two groups: 20 normal controls, who are healthy subjects without known kidney disease or nephrolithiasis, and 20 subjects with documented recurrent nephrolithiasis and hypercalciuria. Patients will be recruited from Dr Goldfgarb's stone clinic at VA Hospital and controls would be voluntary participants from NYU School of Medicine. Subjects who are pregnant or nursing, taking alcohol or drugs, have known CKD or are unable to give consent would be excluded from the study. Any diuretics or citrate containing drugs would be held for a period of 2 weeks during the study period to achieve washout of the effects of those drugs on urine chemistries. Oral STS 10mmol (10ml of 25% STS) BID will be administered to both groups for 7 days; four 24 hour urine collections, 2 prior and 2 at the end of the study, would be done with all participants. A diet diary would be maintained by subjects concomitantly during the study periods. The investigators then plan to compare the two groups in terms of urine chemistries to detect any changes in these parameters with thiosulfate administration. Based on prior animal experiments and human studies with STS the investigators anticipate that it would have a favorable effect on the supersaturation of Ca oxalate/phosphate and therefore its long term use would be helpful in preventing nephrolithiasis.
The intervention consists of two sessions of poem writing. Each session lasts for 3 hours. The instructors for each session will include two experienced Chinese teachers or drama directors from Bestreben Drama Association Limited. Adherence to the protocol will be evaluated by two independent reviewers.
A single dose of albuterol 180 mcg delivered with Spiromax®, an inhalation-driven, multi-dose dry powder inhaler (2 inhalations). Placebo inhalers used to maintain the blind.
BACKGROUND: Although the indoor environment has been proposed to be associated with childhood sleep health, to our knowledge no study has investigated the association between home renovation and childhood sleep problems.
METHODS: The study included 186,470 children aged 6-18 years from the National Chinese Children Health Study (2012-2018). We measured childhood sleeping problems via the Chinese version of the Sleep Disturbance Scale for Children (C-SDSC). Information on home renovation exposure within the recent 2 years was collected via parent report. We estimated associations between home renovation and various sleeping problems, defined using both continuous and categorized (binary) C-SDSC t-scores, using generalized mixed models. We fitted models with city as a random effect variable, and other covariates as fixed effects.
RESULTS: Out of the overall participants, 89,732 (48%) were exposed to recent home renovations. Compared to the unexposed group, children exposed to home renovations had higher odds of total sleep disorder (odd ratios [OR] = 1.3; 95% confidence interval [CI] = 1.2, 1.4). Associations varied when we considered different types of home renovation materials. Children exposed to multiple types of home renovation had higher odds of sleeping problems. We observed similar findings when considering continuous C-SDSC t-scores. Additionally, sex and age of children modified the associations of home renovation exposure with some of the sleeping problem subtypes.
CONCLUSIONS: We found that home renovation was associated with higher odds of having sleeping problems and that they varied when considering the type of renovation, cumulative exposure, sex, and age differences.
<P>PROBLEM TO BE SOLVED: To provide medicines comprising hydroxypropylmethylcellulose, sustained in release of active components such as water-soluble drugs by improving fluidity and compression moldability of powders.  <P>SOLUTION: The sustained release medicines are obtained by tableting powder components comprising active ingredients, hydroxypropylmethylcellulose (HPMC), spray dried granular products of anhydrous calcium hydrogen phosphate and, if necessary, crystalline cellulose. The water-soluble components such as phenylpropanolamine hydrochloride are included in the active ingredients. The methoxy content of HPMC may be about 19-24 wt.% and the hydroxypropoxy content may be about 4-12 wt.%. The ratio of each component is 5-100 pts.wt. anhydrous dibasic calcium phosphate and 1-50 pts.wt. crystalline cellulose based on 100 pts.wt. HPMC. The sustained release medicine may comprise a sustained release part and a rapid release part.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Obesity poses significant challenges, necessitating comprehensive strategies for effective intervention. Bariatric Surgery (BS) has emerged as a crucial therapeutic approach, demonstrating success in weight loss and comorbidity improvement. This study aimed to evaluate the outcomes of BS in a cohort of 48 Uruguayan patients and investigate the interplay between BS and clinical and metabolic features, with a specific focus on FSTL1, an emerging biomarker associated with obesity and inflammation. We quantitatively analyzed BS outcomes and constructed linear models to identify variables impacting BS success. The study revealed the effectiveness of BS in improving metabolic and clinical parameters. Importantly, variables correlating with BS success were identified, with higher pre-surgical FSTL1 levels associated with an increased effect of BS on BMI reduction. FSTL1 levels were measured from patient plasma using an ELISA kit pre-surgery and six months after. This research, despite limitations of a small sample size and limited follow-up time, contributes valuable insights into understanding and predicting the success of BS, highlighting the potential role of FSTL1 as a useful biomarker in obesity.
Green space exposure has been inversely associated with blood pressure (BP) levels and hypertension risk. However, empirical evidence on the underlying mechanisms are lacking. This study examined the association of green space exposure with BP and hypertension, and assessed the mediating effects by air pollution, mental health, physical activity, and weight status. Survey data from 719 adults, who lived in Guangzhou (China) in 2016, were used. Three area-level green space indicators, including network distance to the nearest park, percentage of green space and Normalized Difference Vegetation Index within a 1 km Euclidean buffer around residence and workplace, were calculated and linked to individual-level BP measurements. Structural equation models were applied to estimate the direct and indirect associations of the various green space indicators on systolic BP (SBP), diastolic BP (DBP), and hypertension, respectively. After adjusting for multiple covariates, longer network distance to green space was directly associated with higher SBP. Compared to the reference group (0-500m), the differences were 0.11 mmHg (95% CI = 0.03 to 0.19, P = 0.006) for 500-1000m, 0.03 mmHg (95% CI = -0.05 to 0.12, P = 0.45) for 1000-1500m, and 0.16 mmHg (95% CI = 0.09 to 0.23, P < 0.001) for >1500m, respectively. The overall and direct associations were significant for all three indicators (distance or density) with or without considering workplace exposure. The association between network distance to green and SBP was partially (18.4%, 95% CI = 0-42.1%) mediated by mental health. There was no statistical evidence that air pollution, physical activity, or weight status mediate the association. Secondary analyses for other indicators and other outcomes showed similar results. Both distance to green space and more green space around residence and workplace were associated with lower BP and lower risk of hypertension in adults living in a Chinese metropolitan. Mental health partly mediated the association.
The present invention belongs to a traditional Chinese medicine preparation, and particularly relates to a preparation of an oral disintegrated tablet for clearing blood blockage, and the preparation technology for curing cerebrovascular disease sequelae, coronary heart disease and angina pectoris. The preparation of the present invention is composed of panax notoginseng saponin, talcum powder, gum arabic, mannitol, microcrystalline cellulose, polyvinylpolypyrrolidone, sodium hydroxymethyl starch, aspartame, flavoring lemon essence and magnesium stearate according to weight ratios. Firstly, all the raw materials and the auxiliary materials are sieved. Secondly, the panax notoginseng saponin is uniformly mixed with the mannitol and the talcum powder according to prescriptions. Thirdly, the mixture is thoroughly and uniformly mixed with the rest auxiliary materials, and is sieved. Fourthly, the content of the total saponin is measured. Finally, all the materials are tabletted and made into finished products. The preparation of the present invention is mainly used for curing ischemic cerebrovascular disease, cerebral infarction, coronary heart disease, hyperviscous blood concretion and hemorrhagic stroke, can inhibit platelet aggregation, decreases fibrinogen, improves microcirculation, reduces vascular resistance, increases blood flow, etc. The preparation has the advantages of short curing courses, high effective speed, no toxic and side effect, reasonable price, etc., and is worth clinically popularizing.