anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The mechanistic target of rapamycin (mTOR) predominantly regulates the expression and activity of placental nutrient transporters. The mTOR pathway can be activated by several nutrients, including the essential amino acid methionine. Additionally, previous research in nonruminant animals suggests that mTOR is influenced in a sexually dimorphic manner. In bovine, there is limited understanding of how maternal nutrition and offspring sexual dimorphism affect the placental transfer of nutrients. Thus, we investigated the effects of increasing the supply of dietary methionine to beef cattle heifers during mid-gestation on mTOR signaling, placental nutrient transporters, and fetal growth in male and female offspring. Forty purebred Angus heifers were used in a randomized complete block design experiment. From days 90 to 180 of gestation, heifers received a basal diet with no added methionine (CON, n = 20), or the basal diet plus 8.3 g of rumen-protected methionine (MET, n = 20) per animal daily. All animals received a basal diet in the first and third trimesters of gestation. Cotyledonary tissue samples were collected at parturition and utilized to examine the mTOR pathway and nutrient transporters through protein and gene expression analysis. The offspring's body weight was measured at birth. Data were analyzed using a mixed model that included the fixed effect of treatment, offspring sex, their interactions, and the random effect of block. At day 170 of gestation, MET-supplemented heifers showed higher plasma concentrations of methionine and glutamate (P < 0.01) and lower glycine and proline levels (P ≤ 0.01) compared to the CON group. A treatment × sex interaction was observed for calf birth weight (P = 0.03). In heifers that delivered male calves, MET supplementation increased the birth weight of the calves (P < 0.01). However, the dietary treatments had no effect on the birth weight of female calves (P = 0.32). The increase in birth weight of male calves from MET-fed heifers resembles the upregulation of placental mTOR and phosphorylated mTOR (P ≤ 0.03), as well as the amino acid transporters SLC1A5, SLC7A5, SLC38A6, and SLC38A11, and the glucose transporters SLC2A1 and SLC2A8 (P ≤ 0.05). Our findings suggest that increasing the supply of methionine to beef heifers during mid-gestation can modulate placental nutrient transport and fetal growth in a sex-dependent manner and that these effects are mediated, at least in part, by the mTOR pathway.
This is a randomized single-center prospective survey study to describe the patient utilization of opioid destruction bags in the post-operative period. Patients who underwent surgery for Total Knee Arthroplasty (TKA) or Total Hip Arthroplasty (THA) will be eligible for inclusion if discharging to home with an opioid prescription. Patient data will be excluded if they are under 19 years of age, taking opioids prior to surgery or not prescribed an opioid at discharge. Patients will be excluded from the data if readmitted to hospital during follow-up time period, unable to be reached patients via phone/email after attempts on three separate days, did not have any leftover opioids after surgery, unwilling to answer survey questions or still taking opioids at time of survey. Eligible patients will be randomized between two groups: 1) Control group will receive current standard of care 2) Intervention group will receive a specialized handout and patient education on the safe storage of opioid medications, importance of opioid destruction, opioid destruction options and medication destruction (Deterra) bag before discharge. Participants will be phoned/emailed six to eight weeks post-surgery to complete a survey. Attempts will be made on three separate days to reach the patient via phone. If email is preferred by subject, three reminders will be sent to complete the survey. If patient is unreachable, then patient will be considered lost to follow up. Survey questions will be comprised of various question styles, including: yes/no, multiple choice, and free text answers.
BACKGROUND: Immediate breast reconstruction (IBR) with direct to implant (DTI) is the preferred method of reconstruction by many surgeons and patients, however, acellular dermal matrix (ADM) and other synthetic meshes are expensive especially in low- and middle-income countries. AIM OF THE WORK: To evaluate the technique, indications, aesthetic outcomes, and short and long-term complications of DTI breast reconstruction performed with Ultrapro®, a low-cost alternative mesh to ADM and other synthetic meshes.
METHODS: Our study is a prospective cohort study that was conducted on 133 patients who experienced IBR following nipple-sparing mastectomy (NSM) or skin sparing mastectomy (SSM) using silicone implants and Ultrapro® mesh between December 2020 and December 2023. Techniques used were either sub-pectoral or pre-pectoral, evaluating aesthetic outcome, complication rate and patient satisfaction using breast Q questionnaire.
RESULTS: We included 133 patients (141 breasts) with a median age of 39 years. Mean duration of follow up: 20.364 ± 5.39 months. The sub-pectoral and the pre pectoral techniques were used for 80 breasts and 61 breasts respectively. We used the Ultrapro® mesh in all our patients. Smooth round silicone implants were used. The overall Major complications rate was 16.3%. 8 implants (5.7%) were lost within 6 months post-operatively while 2 implants were removed in the late post-operative period (after 6 months) one due to rupture and the other due to local recurrence. Capsular contracture Baker 3 and 4 was observed in 36 breasts (25%), 31 of them had post mastectomy radiotherapy treatment. 11 (7.8%) were managed by capsulotomies and re-insertion of the same implant. Radiotherapy was a significant risk factors for major complications and capsular contracture with p value of (0.01) and (0.0001) respectively.
CONCLUSION: DTI in properly selected patients offers excellent outcomes and patient satisfaction. The complication rate is low and improves with the experience of the surgeon. The Ultrapro® mesh is a safe, low-cost alternative to ADM or other synthetic meshes especially in low socioeconomic countries. Radiotherapy is a significant risk factor for major complications and capsular contractures.
Daily oral administration of Metformin with a 12-week exercise training program consisting of 3 days per week of aerobic exercise training. The dose of Metformin will begin as one 500 mg tablet for the first week and will increase by 500 mg/day/week until reaching 2000 mg/day by week 4. Supervised aerobic exercise 3 days per week followed by a carbohydrate drink along with daily oral administration of Metformin.
PURPOSE:To obtain the title composition having good foaming ability to give creamy foam and suitable for use as a lowly irritant shampoo, etc., by using as the constituents a sugar-base nonionic surface active agent and a compound having a sugar residue and a cationic group. CONSTITUTION:A detergent composition which contains a sugar-base nonionic surface active agent [e.g. a compound of formula I (wherein R<1> is 8-18C alkyl, alkenyl or alkylphenyl; G is a 5-6C reducing sugar; n is 0 to 20; and p is 1 to 10)] and a compound having a sugar residue and a cationic group [e.g. a compound of formula II (wherein G<1> and G<2> are each H, a monosaccharide residue or an oligosaccharide residue; R<5> and R<6> are each H, 1-5C alkyl or hydroxyalkyl; R<7> is H, 1-12C alkyl, hydroxyalkyl or benzyl; M is halogen or alkyl sulfate; and m is 2 to 4)]. This composition has good foaming ability to give creamy foam and is lowly irritant. Therefore it is suitable for use particularly as a detergent of which the foam plays an important role, such as a shampoo or a body shampoo.
Diabetic foot causes hospitalization, amputation and serious health problems in individuals. This situation also leads to loss of productivity of the individual, negatively affecting mental health and quality of life; It creates a serious economic burden on the family and healthcare system. However, it is stated that the development of diabetic foot can be reduced by 85% with good foot care, education and a multidisciplinary team approach. Diabetes is observed in the majority of hemodialysis patients. Foot care becomes even more important if you have more than one chronic disease. The aim of this study is; To determine the effect of "Diabetic foot care training" given to diabetic hemodialysis patients on foot care behavior. The study was planned as a randomized controlled experimental study. It was planned for diabetic hemodialysis patients who were treated in a dialysis center with a study permit. The population of the research consists of 64 diabetic hemodialysis patients. The sample consists of individuals who agreed to participate in the study. Number, percentage, mean and standard deviation will be used as descriptive statistical methods in the evaluation of the data. A normal distribution test will be applied to determine whether the research variables have a normal distribution. In case the research variables do not show normal distribution (p\<0.05). In the analysis of variables for which the normality assumption is not met, non-parametric analysis methods Mann Whitney U (for comparisons of two groups) and Kruskal Wallis (for comparisons of three or more groups) will be used. Spearman correlation analysis will be performed to determine the relationship between the continuous variables of the research.
FIELD: medicine. SUBSTANCE: method involves separating cells of various organ tissues from abortion fetus of 17- 21 weeks intrauterine development. Suspensions are produced. The suspensions, having increased contents of regional trunk cells, are selected. Separate identified regional trunk cell cultures, regional blast cells possessing high migration activity, differentiated cells, special cells like pancreas beta-cells and biologically active substances containing in the fetal tissues are collected. The number of transplant cells varies from 25•10 4  to 10•10 7 . Viability of cells composing the transplant is not less than 80-90%, II class histological compatibility antigen expression is not greater than 8-15%, spontaneous activity of Ca 2+ /Mg 2+ -dependent endonuclease is not less than 0.1 conditional units, induced activity of Ca 2+ /Mg 2+ -dependent endonuclease is from 0.3 to 9 conditional units, CD95 marker representation rate is not greater than 5%. The cellular transplant optionally has additions like growth factors and/or migration factors, and/or specific proteins, and/or antioxidation agents and so on. EFFECT: enhanced effectiveness of treatment; high safety level of cellular transplants produced from fetal tissues. 10 cl
Workers in the United States spend large amounts of time on the job, making the workplace a key venue for preventive health programs. A workplace risk that has received limited attention is solar ultraviolet radiation (UVR). Unprotected exposure to solar UVR of outdoor workers can produce both an immediate acute harm (i.e., severe sunburn) and long-term skin damage that can elevate the risk of developing skin cancers. Preventing skin cancer is a priority due to its high prevalence; tendency to recur; association with other cancers; and lost productivity ($66.9 billion in losses were attributed to melanoma-related mortality from 1990-2008). Sun Safe Workplaces (SSW) is a comprehensive occupational sun safety education and policy intervention that was tested by Klein Buendel, Inc.'s (KB) research team in a randomized control trial with 98 cities, counties, and special districts in Colorado. Posttesting was completed in November 2013. The SSW intervention focused on three sectors in the organizations: public works, public safety, and parks and recreation. Half of the employers received the SSW intervention, with the remaining employers in the control condition receiving basic sun safety information. Preliminary analyses indicate that 80% of employers in the SSW intervention condition provided sun safety education to employees and 36% adopted formal sun protection policies. No control organizations reported policy adoption. KB will conduct a two-year follow-up study on the benefits of the SSW intervention (i.e., increasing employees' sun protection) and return on investment (ROI; benefits relative to intervention costs). Employee behavior was not assessed in the current SSW trial because it was uncertain whether the SSW intervention would result in uptake of education and policy and thus have the potential to influence their sun protection practices. The proposed two-year follow-up of the 98 organizations in the SSW trial will include: (1) surveys with employees (n=10,787) and front line supervisors (n=767) to assess employees' sun protection practices and workplace actions to support employee sun safety; (2) on-site observations of sun protection actions by the employers (e.g., posters, sunscreen, shade structures); and (3) tracking of the costs of implementing the SSW intervention and induced employer costs. The proposed analyses will compare the sun protection practices of employees a) between workplaces that received the SSW intervention and controls and b) among workplaces that provided education and adopted policy, provided education only, and control workplaces. Analyses will determine if the extent of sun protection actions by employers influences employees' sun safety practices. The economic evaluation will estimate the ROI (i.e., comparison of the estimated program benefits to combined cost elements). The proposed study is significant and innovative because it provides critical information applicable to a wide range of industrial sectors with outdoor workers on a workplace risk that has received scant attention. Determining the effectiveness and ROI of prevention programs is essential for national and local resource investment.
OBJECTIVE: A set of indicators has been reported to measure the quality of care for cirrhotic patients, and previously published studies report variable adherence rates to these indicators. This study aimed to assess the quality of care provided to cirrhotic outpatients before and after an educational intervention by determining its impact on adherence to quality indicators.
METHODS: We conducted a quasi-experimental, cross-sectional study including 324 cirrhotic patients seen in 2017 and 2019 at a tertiary teaching hospital in Spain. Quality indicators were assessed in five domains: documentation of cirrhosis etiology, disease severity assessment, hepatocellular carcinoma (HCC) screening, variceal bleeding prophylaxis, and vaccination. After identifying areas for improvement, an educational intervention was implemented. A second evaluation was performed after the intervention to assess changes in adherence rates.
RESULTS: Before the intervention, adherence rates were excellent (>90%) for indicators related to variceal bleeding prophylaxis and documentation of cirrhosis etiology, acceptable (60-80%) for HCC screening and disease severity assessment, and poor (<50%) for vaccinations. After the educational intervention, there was a statistically significant improvement in adherence rates for eight indicators related to HCC screening (70-90%), disease severity assessment (90%), variceal bleeding prophylaxis (>90%), and vaccinations (60-90%).
CONCLUSION: Our study demonstrates a significant improvement in the quality of care provided to cirrhotic outpatients after an educational intervention. The findings highlight the importance of targeted educational interventions to enhance adherence to quality indicators in the management of cirrhosis.
The invention relates to a walnut peel hair dye and a preparation method thereof. The walnut peel hair dye comprises a solvent A, a solvent B and a solvent C matched in use. The solvent A comprises the components in percentage by weight as follows: 3-8% of cysteine, 0-3% of hydroxyethyl cellulose and deionized water. The solvent B comprises the components in percentage by weight as follows: 2-20% of ferric salt, 2-20% of ferrite, 2-20% of azone, 0.5-3% of sodium sulfite and deionized water. The solvent C comprises the components in percentage by weight as follows: 10-20% of walnut peel, 3-10% of gallnut, 1-4% of mulberry, 2-6% of Semen sesami nigrum, 0.5-2% of Angelica sinensis and deionized water. The hair dye provided by the invention has the beneficial effects that natural plant extracts are used as main components of the hair dye which does not contain chemical substances such as aniline, strong oxidant and the like and is natural and free from toxicity, so that blue-black and purple black of hair after application of some hair dyes are avoided. In addition, nutritional components are added to promote hair to absorb nutrition, so that the hair is more gentle and agreeable.
OBJECTIVES: I. Compare the efficacy of interleukin-2 plus histamine dihydrochloride (Maxamine) vs no further therapy in prolonging the leukemia free survival in patients with acute myeloid leukemia in first or subsequent complete remission (CR) following consolidation therapy. II. Compare the relapse rate, overall survival, and quality of life in this patient population treated with interleukin-2 plus Maxamine vs no further therapy. III. Compare the remission inversion rate in patients in subsequent CR with this treatment regimen vs no further therapy.

OUTLINE: This is a randomized, open label, parallel, multicenter study. Patients are stratified according to complete remission (first vs subsequent). Patients are randomized to one of two treatment arms. Arm I: Following consolidation chemotherapy or autologous stem cell transplantation, patients receive interleukin-2 subcutaneously followed by histamine dihydrochloride subcutaneously over 5-7 minutes twice daily on days 1-21. Treatment repeats every 6 weeks for 3 courses and then every 9 weeks for 7 courses in the absence of disease relapse or unacceptable toxicity. Arm II: Patients receive no further therapy following consolidation chemotherapy or autologous stem cell transplantation. Quality of life is assessed prior to study, and at visits 6, 7, 10, 11, 16, 17, and 22. Patients are followed for relapse and survival every 3 months for 2.5 years.

PROJECTED ACCRUAL: A total of 360 patients will be accrued for this study.
Participants randomized to the wait-list control group will complete the same measures of lifetime stress, autonomic reactivity, depression, anxiety. The identical treatment will be offered to control participants after the 6-week time point.
1484454 Acrylic acid copolymer solutions; dental cements NATIONAL RESEARCH DEVELOPMENT CORP 14 Aug 1974 [21 Aug 1973] 39383/73 Heading C3P A cement-forming liquid suitable for use as a component of a poly(carboxylate) cement comprises an aqueous solution of a water-soluble copolymer of acrylic acid, the copolymer having an average molecular weight of less than 20,000, and the solution having a viscosity (measured with a falling sphere viscometer at 21‹ C.) of 5-40 poise. The acrylic acid is preferably copolymerized with itaconic acid; other suitable acidic and non-acidic comonomers are also disclosed. The liquid is suitably prepared by polymerizing acrylic acid with a comonomer in aqueous solution at a temperature above 85‹ C. in the presence of an initiator, e.g. ammonium persulphate, and a chain transfer agent, e.g. isopropanol. In another aspect, the invention relates to a poly(carboxylate) cement pack comprising as one component a water-soluble copolymer of acrylic acid, the copolymer having a molecular weight as specified above and a 20-65% by weight aqueous solution thereof having a viscosity as specified above; and as another component an ion-leachable cement powder which will react with the copolymer component in the presence of water to give a plastic mass which hardens to form a cement. The copolymer component is suitably in the form of an aqueous solution and the cement powder may be, for example, zinc oxide, optionally including a small proportion of another metal oxide (e.g. magnesium oxide), a fused oxide mixture, an oxide glass or, preferably, a fluoroaluminosilicate glass. Optional additives include fluorides, bacteriostatic agents and antibiotics. In addition to dental applications, the cements are also useful in surgery, particularly orthopaedic surgery.
In Phase I (week 1-4) patients will use the fixed amount of lipase as was prescribed by their treating physician. Phase II (week 5-9) patients will start the self-dosage regimen with pancreatic enzymes (without exceeding the maximum amount of 16 capsules per day). They are properly educated by the researcher and dietician how to adjust the amount of pancreatic enzymes to the fat intake in their diet.
The fusion protein comprises a tetraspanin exosomal protein and one or more immunogenic proteins. The tetraspanin may be CD63, CD9 or CD81, or a fragment or variant thereof. The protein may be capable of eliciting an immune response against a SARS-CoV-2 protein, such as the spike protein. Also claimed is an exosome or membrane preparation comprising the fusion protein, a vaccine composition comprising the exosome or membrane preparation, a nucleic acid molecule, an expression vector and a cell comprising the fusion protein. Also claimed is a method of preventing or ameliorating an infection comprising providing the subject with a therapeutically effective amount of the exosome, membrane preparation or vaccine composition. The exosome may comprise a DC receptor ligand and/or an immune enhancing moiety.
Type 2 diabetes (T2DM) and cigarette smoking are major causes of morbidity and mortality in US, and research indicates there is a complex relationship between these two risk factors. Smoking cessation is recommended as a standard treatment of diabetes by the American Diabetes Association; however, patients with T2DM and their providers are often inundated with other challenging lifestyle changes and disease management. Due to the complex relationship between diabetes and smoking and the large number of competing lifestyle changes recommended at diagnosis, smokers with T2DM may benefit from a contingency management (CM) program that incentivizes cessation. Providing patients tangible rewards to reinforce positive behaviors such as smoking abstinence has been proven effective in substance abuse programs, smoking cessation among pregnant women unwilling or unable to quit, and other population subgroups. In this CRUK2 study the investigators aim to test and further explore the potential effectiveness of financial incentives contingent upon proof of quitting smoking. The investigators will gather diabetes-related contextual factors associated with participation in the program and smoking cessation.