anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
200,081. Truttwin, H. July 3, 1922, [Convention date]. Void [Published under Sect. 91 of the Act]. Lotions; ointments; antiseptics.-Solutions of double iodides, such as bismuth potassium iodide, for treating gonorrhµa and for other therapeutic purposes, are prepared with such relative proportions of alkali iodide and an acid, such as lactic acid, that the solutions are capable of precipitating albumen but do not deposit basic iodides on dilution. Examples are given of solutions containing the double iodide with lactic acid alone or with lactic acid and additional potassium iodide. The solutions may be diluted for use or may be worked up with an ointment base. The bismuth compound may be replaced by corresponding compounds of silver, copper, lead or zinc, and the iodide may be formed in statu nascendi by the reaction of other salts such as bismuth nitrate and potassium iodide. The Specification refers also to the prior use of double iodide solutions containing a small quantity of acid and so large an excess of alkaline iodide as to prevent precipitation of albumens.
A user-based monitoring system, made up of a at least one of each of remote user-monitoring subsystem, central server and authorized-user computer. The user-based monitoring subsystem facilitates collection of user-related data and includes at least one monitoring unit. The central server is remotely located from, and configured for signal communication with, the remote user-monitoring subsystem. The authorized-user computer is remotely located from, and configured for two-way signal communication with, the central server. An authorized user communicates with the central server upon transmitting an identifying authorization code; and can receive reports, based on user-related data collected by a remote user-monitoring subsystem, from the central server. These reports include at least information on the current condition of the remote user being monitored.
Ischemic heart disease (IHD) is a cardiac disorder in which myocardial damage occurs as a result of myocardial ischemia and hypoxia. Evidence suggests that oxidative stress and inflammatory responses are critical in the development of myocardial ischemia. Therefore, the combination of antioxidant and anti-inflammatory applications is an effective strategy to combat ischemic heart disease. In this paper, polyethylene glycol (PEG)-modified cationic liposomes were used as carriers to deliver apigenin (Apn) with small interfering RNA (siRNA) targeting the receptor for glycosylation end products (RAGE) (siRAGE) into cardiomyocytes to prevent myocardial ischemic injury through antioxidant and anti-inflammatory effects. Our results showed that we successfully prepared cationic PEG liposomes loaded with Apn and siRAGE (P-CLP-A/R) with normal appearance and morphology, particle size and Zeta potential, and good encapsulation rate, drug loading and in vitro release degree. In vitro, P-CLP-A/R was able to prevent oxidative stress injury in H9C2 cells, downregulate the expression of RAGE, reduce the secretion of cellular inflammatory factors and inhibit apoptosis through the RAGE/NF-κB pathway; In vivo, P-CLP-A/R was able to prevent arrhythmia and myocardial pathological injury, and reduce apoptosis and the area of necrotic myocardium in rats. In conclusion, P-CLP-A/R has a protective effect on myocardial ischemic injury and is expected to be a potential drug for the prevention of ischemic heart disease in the future.
OBJECTIVE: To assess the association between structural racism and labor neuraxial analgesia use.
METHODS: This cross-sectional study analyzed 2017 U.S. natality data for non-Hispanic Black and White birthing people. The exposure was a multidimensional structural racism index measured in the county of the delivery hospital. It was calculated as the mean of three Black-White inequity ratios (ratios for lower education, unemployment, and incarceration in jails) and categorized into terciles, with the third tercile corresponding to high structural racism. The outcome was the labor neuraxial analgesia rate. Adjusted odds ratios and 95% CIs of neuraxial analgesia associated with terciles of the index were estimated with multivariate logistic regression models. Black and White people were compared with the use of an interaction term between race and ethnicity and the racism index.
RESULTS: Of the 1,740,716 birth certificates analyzed, 396,303 (22.8%) were for Black people. The labor neuraxial analgesia rate was 77.2% for Black people in the first tercile of the racism index, 74.7% in the second tercile, and 72.4% in the third tercile. For White people, the rates were 80.4%, 78.2%, and 78.2%, respectively. For Black people, compared with the first tercile of the racism index, the second tercile was associated with 18.4% (95% CI, 16.9-19.9%) decreased adjusted odds of receiving neuraxial analgesia and the third tercile with 28.3% (95% CI, 26.9-29.6%) decreased adjusted odds. For White people, the decreases were 13.4% (95% CI, 12.5-14.4%) in the second tercile and 15.6% (95% CI, 14.7-16.5%) in the third tercile. A significant difference in the odds of neuraxial analgesia was observed between Black and White people for the second and third terciles.
CONCLUSION: A multidimensional index of structural racism is associated with significantly reduced odds of receiving labor neuraxial analgesia among Black people and, to a lesser extent, White people.
The invention provides a naproxen enteric-coated pellet and a preparation method thereof. The naproxen enteric-coated pellet comprises a drug loading pellet core and a casing layer from inside to outside. The drug loading pellet core is obtained through a centrifugal pellet making process after naproxen raw materials and auxiliary materials are mixed evenly. The casing layer is formed by wrapping the surface of the drug loading pellet core with casing liquid. The steps for preparing the naproxen enteric-coated pellet are simple, and the pellet can be obtained by the pellet core which is wrapped with one layer of casing after pellet forming. The adopted auxiliary materials are all simple and easy to obtain, the price is low, process operation is simple, and the yield is high. The pellet is prepared through the centrifugal pellet making process, consumed time is short, operation is easy, and the weight increment of selected casing materials is small. The naproxen enteric-coated pellet and the preparation method thereof have the advantages of being simple and feasible in production process operation, low in cost, high in efficiency, good in product stability, and capable of achieving industrialized mass production more easily.
The father's phone will be stolen and the father will record the researcher's phone number. Then, before his wife is discharged from the hospital, the father will be interviewed and an appointment will be made to meet at the clinic at a convenient time. During this appointment, the researcher will apply a pre-test and explain information about basic newborn care (hygiene, safety and nutrition) face-to-face and in practice. In addition, brochures about baby care will be provided to fathers that they can use at any time. After this process, the final test will be applied at the end of the 1st month and at the end of the 4th month.
Epileptiform abnormalities that arise over the midline can sometimes be confused with normal sleep transients, such as vertex sharp waves, because of their location and their activation during sleep. However, epileptiform transients can be distinguished from sleep architecture by their waveform and their occurrence during wakefulness. Here, we report a 24-year-old man with drug-resistant epilepsy whose seizures began with tonic posturing of the left leg before progressing to bilateral tonic-clonic activity. During presurgical scalp video-EEG monitoring, his interictal background showed focal spike-wave discharges maximal over the vertex (phase reversal at Cz), with a more-well-defined field over the right parasagittal region (C4/F4), that were present during both sleep and awake states. The discharges met the IFCN criteria for focal interictal epileptiform discharges (spiky morphology, duration shorter than background activity, asymmetric waveform, after-going slow wave, and physiologic distribution) and appeared to be distinct from the patient's vertex sharp waves. Prior to electroclinical seizures, these discharges would increase in prevalence and appear as repetitive spike-wave discharges. When distinguishing epileptiform from nonepileptiform transients, it is critical to consider both their morphology, especially the degree of background disruption and presence of an after-going slow wave, and their variability with state changes.
The Brief family-centered care (BFCC) program was developed and provided for hospitalized patients with BPD and their family caregivers.The BFCC protocol is outlined as 4 treatment sessions, specific goals, and example questions. Four 90-minute in-depth sessions for each dyad were initially held in a quiet interview room to assess family function, then to provide information about BPD, to support and empower the dyads to change communication styles and resolve conflicts, and to sustain or improve family function in the cognitive, affective, and behavioral domains.
Retrospective data collection study of OZURDEX® (dexamethasone intravitreal implant 0.7 mg) administered at least once in accordance with routine clinical practice. No treatment (intervention) is administered as part of this study.
Irradiation of the floor of the pulp chamber with Er,Cr:YSGG laser 2790 nm (Waterlase MD, Biolase) at a Power of 1.5 w, Frequency of 50 Hz, mode S (soft tissue mode) , 20%air and no water with a gold handpiece and Tip type MZ6, for 10 sec.(According to the manufacturer manual iPlus™ software copyright ©2016 BIOLASE, Inc.)('WaterLase-iPlus-UM.pdf', no date). In which a fixed char layer should be formed over the pulpal tissue of the canals orifices. During laser application patients, operator and assistant will use protective eye shields according to the safety measures of the device user manual.
Two hundred restorations will be performed in NCCL of volunteers of both genders, by a single operator, using the Single Bond Universal(3M ESPE) adhesive system. The restorations will be randomly allocated into 4 groups (n-50): D-SE (absence of dentinal sclerosis and self-etching protocol); D-SELETIVE (absence of dentinal sclerosis and selective enamel etching protocol); SD-SE (sclerotic dentin and self-etching protocol); SD-SELETIVE (sclerotic dentin and selective enamel etching protocol). The randomization process within subject was performed by computer-generated tables by a staff member not involved in the research protocol. Details of the allocated group were recorded on cards contained in sequentially numbered, opaque, sealed envelopes. These were prepared by a staff member who was not involved in any of the phases of the clinical trial. The allocation assignment was revealed by opening the envelope on the day of the restorative procedure.The operator was not blinded to group assignment when administering.

The evaluations of the clinical performance of the restorations will be carried out by two previously calibrated examiners, adopting the criteria of the United States Public Health Service (USPHS) for the variables retention, marginal adaptation, marginal staining and postoperative sensitivity . The intragroup statistical analysis will be performed using the McNemar test for the variables retention and postoperative sensitivity; and by Wilcoxon for adaptation and marginal staining. To compare the clinical performance inter groups in the different assessment intervals, Fisher's exact test (retention and postoperative sensitivity) and Kruskal-Wallis (adaptation and marginal staining) will be used.
PURPOSE OF REVIEW: With cochlear implantation becoming increasingly performed worldwide, an understanding of the risk factors, preventive measures, and management of cochlear implant (CI) infection remains important given the significant morbidity and cost it conveys.
RECENT FINDINGS: At the turn of the 21st century there was a decrease in rates of CI infection, particularly meningitis, following the discontinuation of positioner use for CI. However, in more recent years rates of CI infection have remained largely static. Recently, studies evaluating preventive measures such as pneumococcal vaccination, S. aureus decolonization and surgical antibiotic prophylaxis have emerged in the literature.
SUMMARY: Prompt recognition of CI infection and appropriate investigation and management are key, however at present treatment is largely informed by cohort and case-control studies and expert opinion. Preventive measures including pneumococcal vaccination, S. aureus decolonization and preoperative antibiotic prophylaxis play a role in reducing rates of CI infection. However, there remains a need for well designed clinical trials to provide higher level evidence to better guide preventive measures for, and management decisions of, CI infections in the future.
A patient monitoring device includes a microprocessor controller having a clock circuit and memory coupled to one or more sensors such that as the medical appliance is properly fitted to and worn by the patient, the sensors provide an electrical signal confirming that which may be then timed to provide data which confirms a patient's compliance with a recommended protocol. Additionally, other sensors may be used to collect data relating to various operational parameters of the device including the amount of negative pressure presented under a vacuum dome, as desired. A preferred embodiment includes a controller having a microcomputer and sensor for monitoring and collecting data relating to a patient's compliance with a prescribed regimen. The controller is battery operated and is recharged by placing the controller into a cradle which has a wall plug for providing power. The cradle also has a modem and phone connection so that as the controller rests in the cradle, compliance data contained within the controller is automatically transmitted by a modem over the phone line connection to a central location. The central location includes a data network for receiving the patient compliance data, processing and storing it in virtual patient files, and one or more web servers host a web site for displaying the patient data in its processed form.
BACKGROUND: New-onset postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery, increasing the risk of embolism and stroke. There is a lack of information on the use of anticoagulants in this context. The choice between Warfarin and Direct oral anticoagulants (DOACs) also is not well-established. This randomized study aimed to compare the feasibility and safety of Warfarin and Rivaroxaban in preventing thrombotic events in POAF patients after isolated CABG.
METHODS: A total of 66 patients were randomized parallelly with 1:1 allocation to receive either Rivaroxaban (n = 34) or Warfarin (n = 32). Major bleeding events within 30 days after discharge were the primary outcome. Secondary outcomes included minor bleeding events and thrombotic episodes. Clinical characteristics, medication regimens, and left atrial diameter were assessed. Statistical analyses were performed using appropriate tests.
RESULTS: No thrombotic episodes were observed in either treatment arm. No major bleeding events occurred in either group. Four minor bleeding events were reported, with no significant difference between the treatment groups (P = 0.6). Patients with atrial fibrillation had significantly larger left atrial diameters compared to those with normal sinus rhythm (40.5 vs. 37.8 mm, P = 0.01).
CONCLUSIONS: This pilot study suggests that Warfarin and Rivaroxaban are both safe and effective for preventing thrombotic episodes in POAF patients after isolated CABG. No significant differences in major bleeding events were observed between the two anticoagulants. These findings may support the preference for DOACs like Rivaroxaban due to their convenience and easier maintenance.
TRIAL REGISTRATION: Number IRCT20200304046696N1, Date 18/03/2020 https//irct.behdasht.gov.ir/ .
Relating to the field of traditional Chinese medicine preparation, the invention provides a Callicarpa nudiflora Hook. et Arn. extract, and its preparation method and application. Containing flavonoid and water-soluble ingredients, the Callicarpa nudiflora Hook. et Arn. extract is characterized by additionally containing diterpene and triterpene fat-soluble ingredients. The Callicarpa nudiflora Hook. et Arn. extract of the invention is extracted by supersonic waves for preparing bacteriostatic, antiphlogistic, hemostatic and astringent medicaments. The beneficial effect of the extract provided in the invention is that: not only containing flavonoid, tannin and other water-soluble ingredients, but also containing diterpene and triterpene fat-soluble ingredients, the extract of the invention has more complete active ingredients and a comparatively increased content, thus being beneficial to the application of various preparations. Requiring no heating, the preparation method of the invention is energy saving and of high extraction rate.
Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled quantitative structure-activity relationship (QSAR) approaches have shown great promise in small molecule drug discovery but have been less successful in peptide drug discovery due to limited data availability. We have developed a peptide drug discovery platform called streaMLine, enabling rigorous design, synthesis, screening, and ML-driven analysis of large peptide libraries. Using streaMLine, this study systematically explored secretin as a peptide backbone to generate potent, selective, and long-acting GLP-1R agonists with improved physicochemical properties. We synthesized and screened a total of 2688 peptides and applied ML-guided QSAR to identify multiple options for designing stable and potent GLP-1R agonists. One candidate, GUB021794, was profiled in vivo (S.C., 10 nmol/kg QD) and showed potent body weight loss in diet-induced obese mice and a half-life compatible with once-weekly dosing.
PURPOSE: A toothpaste composition containing abrasive, wetting agent, binder, and Meles meles oil is provided to prevent periodontitis and gingivitis. CONSTITUTION: A toothpaste composition contains 0.5-4.0 weight% of Meles meles oil. The composition contains calcium monohydrogen phosphate, calcium carbonate, and aluminum hydroxide as an abrasive. The composition also contains glycerine, sorbitol solution, and amorphous sorbitol solution as a wetting agent. The composition further contains sodium alkyl sulfate, laurylsodium sulfate, sugar fatty acid ester, and sorbitan fatty acid ester as a foaming agent. A method for isolating Meles meles oil comprises: a step of isolating subcutaneous fat from Meles meles; a step of dissolving the subcutaneous fat at a certain temperature and collecting in a container; and a step of purifying with a filter.
OBJECTIVE: This study presents the results of an evaluation of the effectiveness of percutaneous thermal radiofrequency (RF) ablation of spinal nerve roots to reduce spasticity and improve motor function in children with cerebral palsy (CP).
METHODS: A retrospective analysis was conducted on the surgical treatment outcomes of 26 pediatric patients with severe CP (Gross Motor Function Classification System levels IV-V). The assessment protocol included muscle tone assessment using the modified Ashworth scale (MAS), evaluation of passive and active range of motion, gait video recording, and locomotor status evaluation using the Gross Motor Function Measure (GMFM)-88 scale. Thermal RF rhizotomy (ablation of spinal nerve roots) was performed on all patients at the L2-S1 levels at 70°C for 90 seconds. The statistical data analysis was conducted using the t-test and Mann-Whitney U-test. A p value < 0.05 was considered statistically significant.
RESULTS: Before the operation, the average level of spasticity in the lower-limb muscles of all patients was 3.0 ± 0.2 according to the MAS. In the early postoperative period, the spasticity level in all examined muscle groups significantly decreased to a mean of 1.14 ± 0.15 (p < 0.001). In the long-term postoperative period, the spasticity level in the examined muscle groups averaged 1.49 ± 0.17 points on the MAS (p < 0.001 compared to baseline, p = 0.0416 compared to the early postoperative period). Despite the marked reduction of spasticity in the lower limbs, no significant change in locomotor status according to the GMFM-88 scale was observed in the selected category of patients. In the long-term period, during the control examination of patients, the GMFM-88 level increased on average by 3.6% ± 1.4% (from 22.2% ± 3.1% to 25.8% ± 3.6%).
CONCLUSIONS: The findings of this study offer preliminary yet compelling evidence that RF ablation of spinal nerve roots can lead to a significant and enduring decrease in muscle tone among children with severe spastic CP. Further studies and longer-term data of the impact on functionality and quality of life of patients with CP after spinal root RF ablation are needed.
OBJECTIVES: To investigate the expression of signal recognition particle 14 (SRP14) in hepatocellular carcinoma (HCC) and its clinical significance.
METHODS: The data of SRP14 expression in HCC were obtained from bioinformatics study, and from investigation with quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunohistochemical staining and Western blotting in clinical samples. The Kaplan-Meier analysis was used to determine the associations between SRP14 mRNA expression and the overall survival, progression-free survival, and disease-specific survival of HCC patients. The effect of SRP14 on the proliferation and migration of HCC cells were determined by EdU staining, MTS, Transwell and wound-healing assays. The potential mechanism for SRP14 regulating HCC was explored through Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analysis as well as qRT-PCR.
RESULTS: According to the data from GSE14520, TNMplot database and clinical samples, compared with paired tumor-adjacent tissues, non-paired tumor-adjacent tissues and normal tissues, the mRNA expression of SPR14 in HCC tissues was upregulated (all P<0.05). In clinical samples, compared with paired tumor-adjacent tissues, the protein expression of SPR14 in HCC tissues was increased (P<0.05). The increased mRNA expression of SRP14 was associated with good overall survival, progression-free survival, and disease-specific survival in HCC patients. SRP14 inhibited the proliferation and migration of HCC cells in vitro. According to the KEGG and GO enrichment analysis, in non-specific HCC, the genes co-expressed with SRP14 may predominantly regulate protein synthesis, processing, and transport, while in nonalcoholic fatty liver disease related HCC, the genes co-expressed with SRP14 could control multiple signaling pathways such as MAPK, cAMP, PI3K-Akt, and Wnt. Mechanistically, SRP14 up-regulated the mRNA expression of tumor suppressor gene GPRC5A inHCC cells (P<0.05).
CONCLUSIONS: SRP14 may regulate HCC progression and influence patient prognosis.