anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: The increase in the production of substances to enhance the quality of life, the biodiversity of the different ecosystems in Mexico, and the unique characteristics of pediatric patients, contribute to intoxications within this population.
METHOD: Analytical retrospective study of admissions to pediatric emergency care due to poisoning in < 16-year-old (2016 to 2020). Included variables were age, gender, type of toxic substance, exposure characteristics, and the season of the year. Frequencies, percentages, range, average and standard deviation were obteined. In the bivariate análisis, the Chi square test was used. A p-value < 0.05 was considered statistically significant.
RESULTS: Over 5 years, there were 459 cases, with a prevalence of 3.16%. No gender predominance was observed. The most common was caused by venomous animals (28.5%), followed by medication ingestion (27.6%). Only 5% of cases were suicide attempts, the rest were accidental (95%). Children up to 5 years old were more commonly by medication ingestion, hydrocarbons, or household products (p = 0.03, p = 0.0001), while the causes in older children were contact with venomous animals and ingestion of stimulants drugs (alcohol, amphetamines, cannabis, cocaine) (p = 0.0001, p = 0.006). Intoxication with quaternary ammonium herbicides was lethal in all cases.
CONCLUSIONS: Children under the age of 5 are more susceptible to intoxication from common household products. Older kids tend to be more frequently a combination of stimulants drugs.
The intervention group will be asked to practice the mandala twice a week, for 30 minutes, for a month. At the end of one month, the scales will be applied again.
Driver fatigue is a major contributor to road accidents. Therefore, driver assistance systems (DAS) that would monitor drivers' states may contribute to road safety. Such monitoring can potentially be achieved with input from ECG indices (e.g., heart rate). We reviewed the empirical literature on responses of cardiac measures to driver fatigue and on detecting fatigue with cardiac indices and classification algorithms. We used meta-analytical methods to explore the pooled effect sizes of different cardiac indices of fatigue, their heterogeneity, and the consistency of their responses across studies. Our large pool of studies (N = 39) allowed us to stratify the results across on-road and simulator studies. We found that despite the large heterogeneity of the effect sizes between the studies, many indices had significant pooled effect sizes across the studies, and more frequently across the on-road studies. We also found that most indices showed consistent responses across both on-road and simulator studies. Regarding the detection accuracy, we found that even on-road classification could have been as accurate as 70% with only 2-min of data. However, we could only find two on-road studies that employed fatigue classification algorithms. Overall, our findings are encouraging with respect to the prospect of using cardiac measures for detecting driver fatigue. Yet, to fully explore this possibility, there is a need for additional on-road studies that would employ a similar set of cardiac indices and detection algorithms, a unified definition of fatigue, and additional levels of fatigue than the two fatigue vs alert states.
OBJECTIVES: The risk factors and outcomes associated with persistent bacteraemia in Gram-negative bloodstream infection (GN-BSI) are not well described. We conducted a follow-on analysis of a retrospective population-wide cohort to characterize persistent bacteraemia in patients with GN-BSI.
METHODS: We included all hospitalized patients >18 years old with GN-BSI between April 2017 and December 2021 in Ontario who received follow-up blood culture (FUBC) 2-5 days after the index positive blood culture. Persistent bacteraemia was defined as having a positive FUBC with the same Gram-negative organism as the index blood culture. We identified variables independently associated with persistent bacteraemia in a multivariable logistic regression model. We evaluated whether persistent bacteraemia was associated with increased odds of 30- and 90-day all-cause mortality using multivariable logistic regression models adjusted for potential confounders.
RESULTS: In this study, 8807 patients were included; 600 (6.8%) had persistent bacteraemia. Having a permanent catheter, antimicrobial resistance, nosocomial infection, ICU admission, respiratory or skin and soft tissue source of infection, and infection by a non-fermenter or non-Enterobacterales/anaerobic organism were associated with increased odds of having persistent bacteraemia. The 30-day mortality was 17.2% versus 9.6% in those with and without persistent bacteraemia (aOR 1.65, 95% CI 1.29-2.11), while 90-day mortality was 25.5% versus 16.9%, respectively (aOR 1.53, 95% CI 1.24-1.89). Prevalence and odds of developing persistent bacteraemia varied widely depending on causative organism.
CONCLUSIONS: Persistent bacteraemia is uncommon in GN-BSI but is associated with poorer outcomes. A validated risk stratification tool may be useful to identify patients with persistent bacteraemia.
The levels of related hormones (growth hormone, pituitary prolactin, ACTH, cortisol, FSH, thyroid hormone, etc.) were measured in patients with spontaneous craniocerebral injury on the 1st, 7th and 14th day.
PURPOSE:To provide waterproofness to a substance susceptible to the change of properties in response to the reaction of a water system by adding a specific mixture B to a specific mixture A, reacting components of the mixture B to seal the substance with a fatty acid metal salt powder of the mixture A and coating the particle surface of the sealed substance. CONSTITUTION:A mixture A is prepared by adding 0.01 to 100 pts.wt. of a fatty acid metal salt powder to 1 pt.wt. of a substance and separately a mixture B is prepared by adding 0.5 to 2 equivalents of a metal compound to 1 equivalent of a fatty acid. 0.01 to 1 pt.wt. of the mixture B is slowly added to 1 pt.wt. of the mixture A and they are mixed at 40 deg.C to 120 deg.C. Simultaneously, components of the mixture B are reacted to form a fatty acid metal salt anew, permitting the substance to be sealed with a fatty acid metal salt powder of the mixture A and the particle surface of the sealed substance to be coated to form a waterproof film. A waterproof substance can be obtained according to this procedure.
The present invention provides a novel long-acting adrenomedullin derivative that sustains the pharmacological effects of adrenomedullin, which is the parent compound thereof, and exhibits high biological stability when administered to a subject. One embodiment of the present invention pertains to a compound represented by formula (I) [in the formula: A represents a modifying group that is serum albumin; B represents a peptide moiety derived from adrenomedullin or a modified form thereof; and L represents a divalent linking group having a carboxyl group at at least one end thereof, wherein the α-amino group at the N-end of the peptide moiety B forms an amide bond together with the terminal carboxyl group of the linking group L so that the peptide moiety B is linked to the remainder], a salt thereof or a hydrate of the same. Another embodiment of the present invention pertains to: a method for producing the aforesaid compound, etc.; and a pharmaceutical and a prophylactic or therapeutic agent each comprising the compound, etc. as an active ingredient.　(I): A-L-B
There are disclosed compounds of the general formula The heteroatom X is preferably oxygen, but may have other values. The group W is preferably a carbonyl group, but may have other values. The preferred heterocyclic ring is thus a 4-oxo-4H-1-benzopyran ring. This may have a wide range of R2, R3, R6 and R7 substituents. Y is a linking group, chosen from a wide range, but including -COO- , -CONH- , -O- , -SO2- and -SO2NH-. Z is an alkylene chain, and B is a complex amine. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts are useful for the treatment of hypertension and urinary tract troubles associated with benign prostatic hypertrophy, and for the treatment of other diseases.
The invention relates to a traditional Chinese medicine formula taken before drinking and capable of reducing concentration of alcohol in human body after drinking, protective liver and nourishing stomach. According to the traditional Chinese medicine formula, 150-300 parts of a salvia miltiorrhiza extract, 100-250 parts of a polygonatum rhizome extract, 50-150 parts of a white peony root extract, 50-230 parts of a mulberry extract, 10-40 parts of an aloe extract and clinically acceptable auxiliary materials are made into hard capsules, tablets, granules and pulvis. The traditional Chinese medicine formula is based on traditional Chinese medical theory. With compatibility of various raw materials, the traditional Chinese medicine formula has effects of strengthening the spleen and stomach, clearing heat and promoting dieresis, nourishing yin and retaining yin with astringent and dispel the effects of alcohol and protecting liver. The traditional Chinese medicine formula is taken before drinking, and can be used to accelerate metabolism of alcohol in human body, reduce symptoms of dizziness and headache after drinking, protect liver and stomach and avoid damage of alcohol to liver and stomach after drinking. Through preliminary trials of animals and human body, it is found that the traditional Chinese medicine formula can reduce concentration of alcohol in human body after drinking and simultaneously achieve the effect of protecting liver and nourishing stomach if taken before drinking.
<P>PROBLEM TO BE SOLVED: To provide a bathing agent excellent in skin-tightening effects, slimming effects and skin care effects.  <P>SOLUTION: The bathing agent comprises Huang Hua Cai (yellow flower vegetable) or an extract thereof. The bathing agent further contains caffeine or a salt thereof, a bicarbonate salt or a carbonate salt. Huang Hua Cai is a general term of flowers and buds of plants originating from Hemerocallis Plicata Stepf, Hemerocallis fulva var. fluva, Hemerocallis fulva var. kwanso, Hemerocallis flava, Hemerocallis flava var. minor, and analogous plants thereof belonging to the family of Liliaceae. The compounded amount of Huang Hua Cai or an extract thereof in the whole amount of the bathing agent is preferably 0.0001-30 mass%, particularly preferably 0.0002-5 mass%, in terms of dried matter.  <P>COPYRIGHT: (C)2008,JPO&INPIT
In addition to routine care by physician and nurses, Patients in interventional group will receive two consecutive face to face interview and counseling of 20-40 minutes during the baseline period and the first follow-up period at 3-month by clinical pharmacist. Teaching and counseling session involves information on various non-pharmacological and pharmacological disease management strategies.
PURPOSE:To provide a new compound excellent in long acting properties, having a strong fragrance and flavor and useful as a fragrance-imparting agent or a flavor-imparting agent for various kinds of cosmetics, detergents, etc. CONSTITUTION:This compound of formula I (R1 and R2 are each a 1 to 6C alkyl), e.g. ethyl a-methyl-beta-(2,4,5-trimethylphenyl)glycidate is synthesized by reacting 2,4,5-trimethylbenzaldehyde of formula II with an alpha-brominated ester of formula III in the presence of a condensation agent (e.g. sodium hydride dispersed in fluid paraffin) and preferably in the coexistence of a reaction initiator (e.g. methyl alcohol) in a solvent (e.g. THF) at -15 to 10 deg.C. The compound of formula I has a strong fragrance similar to that of an pear or an apple and is excellent in stability of flavor with time under heating and durability of fragrance.
Chronic kidney disease (CKD) is a significant public health issue affecting millions of individuals worldwide. Hemodialysis, the most common modality for renal replacement therapy, is a life-sustaining procedure for end-stage renal disease (ESRD) patients. Despite its benefits, hemodialysis can be associated with various complications, and one of the most commonly reported symptoms is fatigue. Hemodialysis-associated fatigue (HAF) is characterized by persistent tiredness, lack of energy, and reduced motivation, which significantly impacts the quality of life and functional capacity of patients.

Several potential factors contribute to HAF, including patient-related variables, dialysis-related factors, and comorbidities. Understanding the underlying mechanisms and factors contributing to HAF is essential for improving the overall care and quality of life of hemodialysis patients. Targeted interventions to address fatigue could lead to better adherence to dialysis treatment, reduced hospitalizations, and enhanced overall well-being for this vulnerable patient population. To date, limited research has been conducted on the subject of HAF, and the available studies often have small sample sizes and diverse methodologies. Therefore, this research aims to delve into the complexities of HAF, exploring its prevalence, potential risk factors, and implications for patient outcomes.
Subjects enrolled in this study will receive Sacituzumab Govitecan in addition to their single agent ARSI as treatment for Castrate-Resistant Prostate Cancer. Dose will be calculated per protocol in milligrams based on the subject's body weight at the beginning of each cycle or more frequently if weight changes \>10%. Subjects will be treated on days 1 and 8 in a 21-day cycle, minimum 3 cycles.
PURPOSE: To identify the key infection processes and risk factors in Computed Tomography (CT) examination process within the standard prevention and control measures for the COVID-19 epidemic, aiming to mitigate cross-infection occurrences in the hospital.
METHOD: The case hospital has assembled a team of 30 experts specialized in CT examination. Based on the CT examination process, the potential failure modes were assessed from the perspective of severity (S), occurrence probability (O), and detectability (D); they were then combined with corresponding risk prevention measures. Finally, key infection processes and risk factors were identified according to the risk priority number (RPN) and expert analysis.
RESULTS: Through the application of RPN and further analysis, four key potential infection processes were identified, including "CT request form (A1)," "during the scan of CT patient (B2)," "CT room and objects disposal (C2)," and "medical waste (garbage) disposal (C3)". In addition, eight key risk factors were also identified, including "cleaning personnel does not wear masks normatively (C32)," "nurse does not select the vein well, resulting in extravasation of the peripheral vein for enhanced CT (B25)," "patient cannot find the CT room (A13)," "patient has obtained a CT request form but does not know the procedure (A12)," "patient is too unwell to continue with the CT scan (B24)," "auxiliary staff (or technician) does not have a good grasp of the sterilization and disinfection standards (C21)," "auxiliary staff (or technician) does not sterilize the CT machine thoroughly (C22)," and "cleaning personnel lacks of knowledge of COVID-19 prevention and control (C33)".
CONCLUSION: Hospitals can publicize the precautions regarding CT examination through various channels, reducing the incidence of CT examination failure. Hospitals' cleaning services are usually outsourced, and the educational background of the staff employed in these services is generally not high. Therefore, during training and communication, it is more necessary to provide a series of scope and training programs that are aligned with their understanding level. The model developed in this study effectively identifies the key infection prevention process and critical risk factors, enhancing the safety of medical staff and patients. This has significant research implications for the potential epidemic of major infectious diseases.
Synthesis of multifunctional dendrimeric and hyperbranched polymers for application as drug delivery systems of bioactive pharmaceutical compounds and as gene delivery systems (carriers of genetic material), the latter through condensation with genetic material. Specifically, the present invention deals with the synthesis of multifunctional compounds based on appropriate dendrimeric or hyperbranched polymers at the terminal surface of which have been introduced functional groups X, Y, Z. In addition, for gene delivery to cells these multifunctional systems will become cationic for the formation of complexes with negatively charged genetic material. The functional groups render the delivery systems recognizable by complementary cell receptors. Furthermore they render the systems stable in the biological milieu and facilitate their transport through cell membranes.   (62) Divided Out of 541661
An anastomosis staple comprising of a plurality of vessel engaging members (14) and a binding structure (12) holding the vessel engaging members together is described. The binding structure has at least one bioabsorbable element. The binding structure is rigid enough to allow for deployment and quickly resorbs to avoid problems associated with intimal hyperplasia and physical hindrance of secondary interventional procedures. The vessel engaging members may be comprised of superelastic or shape memory metal and are independent from one another. The members may be equidistant from one another and embedded within the binding structure. The composite staple can preferably serve as a drug delivery vehicle.
The invention discloses a tumor-targeted nanometer drug delivery system for cooperative chemotherapy and photodynamic therapy and a preparation method thereof. The drug delivery system is prepared from carboxymethyl chitosan, folate, a photosensitizer chlorine e6 and adriamycin, wherein the chlorine e6 and the folate are coupled to a carboxymethyl chitosan chain segment through an amido bond, and are loaded to polymer nanoparticles of the adriamycin through an ion exchange method. The nanometer material prepared by the method is high in yield, regular in shape and even in distribution. In-vivo and in-vitro experiments prove that the tumor targeting property of the nanometer preparation can be significantly improved by folate receptor mediation; enrichment on the tumor part is achieved and drug release is controlled. The photosensitizer is capable of effectively reversing the chemotherapy drug resistance and significantly inhibiting the growth of tumors after being irradiated by near-infrared light. Therefore, the related nanometer drug delivery system has good application prospect in the aspect of breast cancer treatment.
Inflammatory arthritis particularly rheumatoid arthritis (RA), psoriatic arthritis and ankylosing spondylitis are potentially disabling conditions which cause joint pain, swelling and deformity and treatments are aimed at preventing these complications. Although treatment has improved with the advent of anti TNF alpha therapies, up to 30% of patients fail to respond to this treatment and in others, treatment is associated with significant side effects. The precise mechanisms of this remain unclear. In addition, there are no sensitive methods available to monitor or predict disease response to treatment aside from testing inflammatory markers in the blood. Understanding the mechanism of action and what governs response to anti TNF therapy will allow development of more specific therapies for inflammatory arthritis. Work in animal models of rheumatoid arthritis has characterised a novel cell type, Th17 cells, important in the inflammatory cascade which are affected in a particular way by anti TNF therapies and may underpin their mechanism of action and side effects.
Behavior- BI: Information-Motivation-Behavioral Skills Model the Information-Motivation-Behavioral Skills (IMB) Model. The 5 sessions are designed to provide participants with the information, motivation, and skills needed to abstain or practice protected sex during the brief acute HIV period, as well as plan for long-term behavioral risk reduction.
Vagus nerve stimulation (VNS) is under clinical investigation as a therapy for heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate its therapeutic effects on three main components of heart failure: cardiac function, cardiac remodeling and central neuroinflammation using a pressure overload (PO) rat model. Male Sprague-Dawley rats were divided into four groups: PO, PO + VNS, PO + VNS sham, and controls. All rats, except controls, underwent a PO surgery to constrict the thoracic aorta (~50 %) to induce HFrEF. Open loop VNS therapy was continuously administered to PO + VNS rats at 20 Hz, 1.0 mA for 60 days. Evaluation of cardiac function and structure via echocardiograms showed decreases in stroke volume and relative ejection fraction and increases in the internal diameter of the left ventricle during systole and diastole in PO rats (p < 0.05). However, these PO-induced adverse changes were alleviated with VNS therapy. Additionally, PO rats exhibited significant increases in myocyte cross sectional areas indicating hypertrophy, along with significant increases in myocardial fibrosis and apoptosis, all of which were reversed by VNS therapy (p < 0.05). Furthermore, VNS mitigated microglial activation in two central autonomic nuclei: the paraventricular nucleus of the hypothalamus and locus coeruleus. These findings demonstrate that when VNS therapy is initiated at an early stage of HFrEF progression (<10 % reduction in relative ejection fraction), the supplementation of vagal activity is effective in restoring multi organ homeostasis in a PO model.
Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen Helicobacter pylori. Those include an alanine-threonine polymorphism in the EPIYA-B phosphorylation motif of the injected effector protein CagA that affects cancer risk by modifying inflammatory responses and loss of host cell polarity. A serine-to-leucine change in serine protease HtrA is associated with boosted proteolytic cleavage of epithelial junction proteins and introduction of DNA double-strand breaks (DSBs) in host chromosomes, which co-operatively elicit malignant alterations. In addition, H. pylori genome-wide association studies (GWAS) identified several other SNPs potentially associated with increased gastric cancer (GC) risk. Here we discuss the clinical importance, evolutionary origin, and functional advantage of the H. pylori SNPs. These exciting new data highlight cancer-associated SNPs in bacteria, which should be explored in more detail in future studies.
This is a 6-month intervention in which participants with 2 or more MS components are randomly assigned to intervention or control group. Intervention comprise individual diet counseling, an exercise plan and monthly lifestyle workshops. Controls receive printed material on healthy eating and lifestyle modification.