anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the vibration and ice group, cold and vibration stimulation will be applied to the child simultaneously. The ring finger of the designated hand was placed on a 10x10 cm ice pack for 30 seconds and subjected to cold application. Simultaneously, vibration stimulation will be applied to the tip of the middle finger area using a vibrator device with dimensions of 3x1 cm and 2x1 cm. After 30 seconds, the ice bag will be removed and the lancet pen will be adjusted for drilling from the fingertip while vibration stimulation continues.
A pharmaceutical composition for treating diabetes and preparation method thereof. The pharmaceutical composition according to the present invention is composed of raw material drugs including radix of Rehmannia glutinosa Libosch; radix of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, Astragalus membranaceus (Fisch.) Bge; rhizoma of Dioscorea opposita Thunb; radix of Pueraria lobata (Willd.) Ohwi Pueraria thomsonii Benth; radix of Trichosanthes kirilowii Maxim, Trichosanthes rosthornii Harms; stigma of Zea mays L; fructus of Schisandra sphenanthera Rehd. Et Wils. and glibenclamide. The pharmaceutical composition according to the present invention has the functions of nourishing kidney-Yin, benefiting vital energy and promoting the secretion of saliva, and is used in treating diabetes of deficiency in both vital energy and Yin, namely non insulin-dependent diabetes.
A transcription-aided selection (TAS) strategy is proposed in this paper, which utilizes the positive regulatory roles of genes involved in the plant immunity pathways to screen crops with high disease resistance. Increased evidence has demonstrated that upon pathogen attack, the expression of diverse genes involved in salicylic acid (SA)-mediated SAR are differentially expressed and transcriptionally regulated. The paper discusses the molecular mechanisms of the SA signaling pathway, which plays a central role in plant immunity, and identifies differentially expressed genes (DEGs) that could be targeted for transcriptional detection. We have conducted a series of experiments to test the TAS strategy and found that the level of GmSAGT1 expression is highly correlated with soybean downy mildew (SDM) resistance with a correlation coefficient R2 = 0.7981. Using RT-PCR, we screened 2501 soybean germplasms and selected 26 collections with higher levels of both GmSAGT1 and GmPR1 (Pathogenesis-related proteins1) gene expression. Twenty-three out of the twenty-six lines were inoculated with Peronospora manshurica (Pm) in a greenhouse. Eight showed HR (highly resistant), four were R (resistant), five were MR (moderately resistant), three were S (susceptible), and three were HS (highly susceptible). The correlation coefficient R2 between the TAS result and Pm inoculation results was 0.7035, indicating a satisfactory consistency. The authors anticipate that TAS provides an effective strategy for screening crops with broad-spectrum and long-lasting resistance.
PCT No. PCT/US93/04055 Sec. 371 Date Oct. 27, 1994 Sec. 102(e) Date Oct. 27, 1994 PCT Filed Apr. 29, 1993The present invention relates to blocking peptides which are capable of binding to ligands for the erbB-2 receptor or the epidermal growth factor receptor (EGFR). The blocking peptides of the invention are used to detect the presence of such ligand molecules. In addition, the blocking peptides are useful in inhibiting or preventing the growth of adenocarcinoma cells which express the erbB-2 receptor or the EGFR.
We will include the teenagers who need intravenous general anesthesia(IVGA), and inject propofol with/without ketamine 0.5mg/kg with full monitor. We will record the EEG during the who operation.
A gram flour mask composition for deep cleansing the feet and removing dead skin comprises gram flour (chick pea flour), honey, milk and water. In a process for cleansing the feet, the above composition is applied to the feet and before wrapping the feet in cling film. The mask is then left to dry. Following this step, the mask is scrubbed off using a towel mitt and the feet are washed in warm water. The client's feet are then bathed in a mixture of warm scented milk and fresh roses and re-washed in warm water to soften soothe and heal the feet. The final step comprises drying the feet and carrying out a reflex zone massage with almond oil.
Children aged from 1 month to \<18 years. In 3 stratified groups : \<2 years, 2-8 years, and \>8 years. About one third of the patients are expected in each age-group.
Each participant will attend 5 sessions per week for a total duration of 4 weeks. The patient will be required to swallow at a given time, with food bolus if possible, and perform maneuvers that favour swallowing strength and efficacy: effortful swallow, specific task for timing and coordination, Masako maneuver. The control group will perform this training for 45 minutes, with a verbal feedback from the speech and language therapist in relation to the efficacy of the performance.
We herein report a 37-year-old man who experienced recurrence of metastatic cardiac rhabdomyosarcoma along with intractable ventricular tachycardia (VT) 7 years after resection of rhabdomyosarcoma in his right elbow. At 36 years old, he developed VT unresponsive to radiofrequency catheter ablation (RFCA). Initially, the cardiac tumor was not detected, but it gradually grew in size at the RFCA site. A surgical biopsy confirmed the diagnosis of metastatic cardiac rhabdomyosarcoma. Despite radiation therapy, cardiac tumor progression and VT instability could not be prevented. Ultimately, the patient died 27 months after the initial documentation of VT.
Obesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most significant avoidable contributor to mortality, whereas stroke stands as the second leading cause of death on a global scale. While changes in lifestyle have been demonstrated to have significant impacts on weight management, the long-term weight loss remains challenging, and the global prevalence of obesity continues to rise. The pathophysiology of obesity has been extensively studied during the last few decades, and an increasing number of signal transduction pathways have been linked to obesity preclinically. This review is focused on signaling pathways, and their respective functions in regulating the consumption of fatty food as well as accumulation of adipose tissue, and the resulting morphological and cognitive changes in the brain of individuals with obesity. We have also emphasized the recent progress in the mechanisms behind the emergence of obesity, as elucidated by both experimental and clinical investigations. The mounting understanding of signaling transduction may shed light on the future course of obesity research as we move into a new era of precision medicine.
Participants in HPPT-US 1 group received one session of HPPT-US treatment which the dose was kept constant. The technique delivers sound waves directly to the myofascial trigger points and results in immediate pain relief.
Carcinogenesis  
Carcinogenicity studies were conducted in Swiss albino mice and Wistar rats. Risperidone was administered in the diet at doses of 0.63 mg/kg, 2.5 mg/kg, and 10 mg/kg for 18 months to mice and for 25 months to rats. These doses are equivalent to approximately 2, 9, and 38 times the maximum recommended human dose (MRHD) for schizophrenia of 16 mg/day on a mg/kg basis or 0.2, 0.75, and 3 times the MRHD (mice) or 0.4, 1.5, and 6 times the MRHD (rats) on a mg/m2 body surface basis. A maximum tolerated dose was not achieved in male mice. There were statistically significant increases in pituitary gland adenomas, endocrine pancreas adenomas, and mammary gland adenocarcinomas. The table below summarizes the multiples of the human dose on a mg/m2 (mg/kg) basis at which these tumors occurred.

Antipsychotic drugs have been shown to chronically elevate prolactin levels in rodents. Serum prolactin levels were not measured during the risperidone carcinogenicity studies; however, measurements during subchronic toxicity studies showed that risperidone elevated serum prolactin levels 5 to 6 fold in mice and rats at the same doses used in the carcinogenicity studies. An increase in mammary, pituitary, and endocrine pancreas neoplasms has been found in rodents after chronic administration of other antipsychotic drugs and is considered to be prolactin-mediated. The relevance for human risk of the findings of prolactin-mediated endocrine tumors in rodents is unknown [see Warnings and Precautions (5.6)].

Mutagenesis  
No evidence of mutagenic or clastogenic potential for risperidone was found in the Ames gene mutation test, the mouse lymphoma assay, the in vitro rat hepatocyte DNA-repair assay, the in vivo micronucleus test in mice, the sex-linked recessive lethal test in Drosophila, or the chromosomal aberration test in human lymphocytes or Chinese hamster ovary cells.

Impairment of Fertility  
Risperidone (0.16 to 5 mg/kg) was shown to impair mating, but not fertility, in Wistar rats in three reproductive studies (two Segment I and a multigenerational study) at doses 0.1 to 3 times the maximum recommended human dose (MRHD) on a mg/m2 body surface area basis. The effect appeared to be in females, since impaired mating behavior was not noted in the Segment I study in which males only were treated. In a subchronic study in Beagle dogs in which risperidone was administered orally at doses of 0.31 to 5 mg/kg, sperm motility and concentration were decreased at doses 0.6 to 10 times the MRHD on a mg/m2 body surface area basis. Dose-related decreases were also noted in serum testosterone at the same doses. Serum testosterone and sperm parameters partially recovered, but remained decreased after treatment was discontinued. A no-effect dose could not be determined in either rat or dog.
To determine the effect of dampening chemoreceptor sensitivity AND decreasing plant gain. The investigators hypothesize that combined therapy with PAP, acetazolamide and oxygen will be superior to PAP plus each intervention alone or placebo in reducing CAHI and the CO2 reserve during sleep in Veterans with CSA.
Within-subject double-blind, administration of hydromorphone via oral capsule. Order of dose randomized session days 3-5.
The present disclosure provides methods of treating polypoidal choroidal vasculopathy comprising administering a therapeutically effective amount of a vascular disrupting agent to a subject suffering from polypoidal choroidal vasculopathy. In certain implementations the vascular disrupting agent is a combretastatin, more preferably combretastatin A-4, or a derivative, prodrug or analog thereof. The vascular disrupting agent can be administered systemically, e.g. intravenously, or non-systemically, e.g. topically, to an eye of the subject. The present disclosure also provides the use of a vascular disrupting agent for the manufacture of a medicament for the treatment or prevention of polypoidal choroidal vasculopathy.
Group A patients will receive static splints.By the end of 4 weeks the splint will be modified and patients will start doing physiotherapy. Movement at MCPJ will be from 0 to 45 degrees.
Latina Friends Motivating the Soul (ALMA). This group receives the intervention six months after the baseline assessment (after the post-intervention, and 3 month assessments have been completed).
This trial is a Phase I, open label trial (meaning that both the research physician and study participants will know which medication is being administered during the trial) in 12 healthy volunteers (referred to as participants) to investigate the effect of ritonavir, a marketed product used in several HIV medications, on the plasma levels of TMC435350, a new investigational drug in process of development for the treatment of hepatitis-C virus (HCV) infections. TMC435350 is a protease inhibitor (PI), a class of drugs that selectively inhibit the replication of the virus thereby inhibiting the progression of HCV infection. Plasma levels of TMC435350 are circulating levels of TMC435350 in the blood that are important for the antiviral activity of TMC435350. Ritonavir has the ability to increase the circulating levels of other compounds administered on the same day as Ritonavir. The trial will consist of 2 sequential sessions (Session 1 and Session 2) and all participants enrolled in the study will enter each session. In Session 1, participants will take TMC435350 200mg orally (by mouth) once daily for 7 days. There will be a waiting period of at least 7 days to allow any drug left in the body after the last treatment in Session 1 to be eliminated before the start of Session 2 (referred to as a "washout period"). In Session 2, participants will take ritonavir 100 mg orally twice daily on Days 1 to 15 and TMC435350 200mg once daily on Days 6 to 12. All study drugs in both treatment sessions will be taken under fed conditions (i. e., participants will eat a standard breakfast within approximately 30 minutes before they take study drug). Full pharmacokinetic profiles of TMC435350 (to investigate how the drug moves through the body, including the absorption, distribution, metabolism and elimination of the drug) will be determined from blood samples obtained on Days 1 and 7 of Session 1 and on Days 6 and 12 of Session 2. Safety and tolerability will be recorded continuously. The total duration of treatment in the study for each participant will be approximately 30 days (includes 7 days of treatment in Session 1, 16 days of treatment in Session 2, and a washout period of at least 7 days between treatment sessions).
FIELD: cosmetology, pharmaceutics, dermatology. SUBSTANCE: innovation deals with application of an agent in cosmetic, pharmaceutical, preferably dermatological composition or with obtaining, at least, one inhibitor of retinoic acid activity. Moreover, said composition is indicated to deteriorate or prevent hair growth. It is, also, indicated to deteriorate hair fall-out. The innovation deals with the method to treat hair including either local or systemic inhibitor of retinoic acid activity and with a kit including an inhibitor of retinoic acid activity and another active component. EFFECT: higher efficiency of hair care. 15 cl, 2 ex, 3 tbl
Sociodemographic information of all participants will be obtained within the scope of the evaluations. Body composition parameters will be measured with Tanita DC360 Body Analysis Scale. In pulmonary function test, Forced vital capacity (FVC), Forced expiratory volume in 1st second (FEV1), Tiffeneau ratio (FEV1/FVC), peak expiratory flow rate (PEF) values will be evaluated with COSMED Pony FX (COSMED; Italy) spirometer. Respiratory muscle endurance will be assessed by Maximum Minute Ventilation will be determined. Pittsburg Sleep Quality, a reliable questionnaire that assesses sleep quality The index will be filled in by the participants. 6 Minutes to assess functional capacity A walking test will be performed and the distance travelled by individuals will be recorded.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmaceutical compositions, containing memantine or its pharmaceutically acceptable salt, for use in treatment of mental disabilities. At the same time memantine or its pharmaceutically acceptable salt is available in medicinal form with prolonged release and is subject to introduction without using mode with dose increase. Also invention subject is pharmaceutical composition, as a result of using which for treatment, therapeutically efficient permanent concentration of memantine in plasma is obtained within 20 days from the moment of composition introduction to a patient. Proposed pharmaceutical composition may be composed in the form of capsule, besides memantine or its pharmaceutically acceptable salt it contains have the ratio of Cmax/Cmean from approximately 2.5 to approximately 1 at least for 6 hours after introduction of composition to a patient. Another aspect of invention consists in the fact that pharmaceutical composition includes memantine, polymer and coating, containing insoluble matrix polymer and water-soluble substance. ^ EFFECT: using proposed compositions makes it possible to eliminate duration of delay in beginning of therapeutic effect in patients who start therapy with memantine. ^ 12 cl, 7 dwg, 36 tbl, 26 ex
Patients randomized to this group will have isovolumetric hemofiltration on Intensive Care Unit. They will have biochemical analysis, Adrenomedullin plasmatic level, Brain Natriuretic Peptide Level, Angiotensin II level, Oxydative stress measurement,sympathetic nervous system, and clinical outcome evaluated at the study beginning,at discharge and 90 days after randomization(plus or minus 3).
Trans-xanthophyll ester concentrates having a trans-xanthophyll ester content of at least four times greater and preferably at least nine times greater than the cis-xanthophyll ester content are obtained. Xanthophyll ester concentrates having a total xanthophyll ester content of at least 40 wt. % and preferably greater than about 55 wt. % are also obtained. A method of obtaining a trans-xanthophyll ester concentrate of high purity includes contacting plant material containing xanthophyll esters with a hydrocarbon solvent for a time sufficient to extract xanthophyll esters from the plant material, separating the hydrocarbon solvent and extract dissolved therein from the remaining plant material, evaporating the hydrocarbon solvent from the dissolved extract to obtain a crude xanthophyll ester concentrate, admixing the crude xanthophyll ester concentrate with an alcohol at approximately ambient temperature to dissolve non-xanthophyll impurities and cis-xanthophyll esters from the concentrate and removing the alcohol containing impurities and cis-xanthophyll esters from the crude trans-xanthophyll concentrate to obtain a purified trans-xanthophyll ester concentrate. By using only the corollas of marigold flowers, lutein ester concentrates of high purity are obtained with pesticide residues absent from the concentrate at parts per billion detection levels.
Systems and methods for formulating a formula for a personalized skin care product for a user. Data inputs reflecting dermal information of the user (e.g., hydration level measurements, oil level measurements, and photographs of the user's skin reflecting a set of skin concerns) are captured by a computing device and used to determine a set of normalized scores. A skin health data set is generated based on the normalized scores and stored in a memory. A skin health metric is determined based on the skin health dataset and stored in a memory. The computing device determines one or more first skin care product formulas based on the user skin health data set using a machine learning framework. The formula(s) can be used to manufacture one or more customized skin care products for the user, and can be iteratively improved over time, such as by collecting additional data from the user over time.
Generation of competent embryoids, plantlets and plants (including seeds) from  Cucumis  sp. explant tissue, e.g., from cotyledonary, root, leaf or stem tissue, by induction followed by promotion of embryoid development in a series of media containing one of more of 2,4-D, BAP and NAA under defined temperature, time and light conditions is disclosed. The explant tissue may be from any plant type: wild or cultivated, hybrid (somatic or sexual), or genetically variant or transformed plants. Competent embryoids may be continuously produced by serial subculture. Serial transfer to novel induction and expression media for defined periods causes sequential development of competent embryoids and plantlets. Transfer to development media permits plantlet development, which in turn progress to mature plants in hardening media and/or soil. The process is applicable to producing encapsulated embryoids from single genotypes or somatic hybrids as "artificial seeds". The process applied to increase of F-1 hybrids permits production of "artificial seeds" (encapsulations) in 1/2 to 1/10 the time it would take to produce natural hybrid seeds. Techniques involving freeze storage and cell suspensions are dislcosed. All representative cultivars were regenerated.
UNLABELLED: Patients with chronic pancreatitis are at risk of developing malabsorption and malnutrition. Exocrine pancreatic insufficiency is accompanied by decreased serum micronutrient levels and low vitamin D levels are a frequent finding in up to 60-80% of patients. The aim of our prospective study was to investigate vitamin D in the blood serum of subjects with chronic pancreatitis with the possibility of influencing the reduced vitamin D levels with supplementation therapy.
MATERIAL AND METHODOLOGY: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined.
RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group.
CONCLUSION: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29).
Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in in vivo experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues.