anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portion of a first region of a target DNA sequence. The vector also includes a second DNA sequence containing at least one sequence portion which is substantially homologous to another portion of a second region of a target DNA sequence. A third DNA sequence is positioned between the first and second DNA sequences and encodes a positive selection marker which when expressed is functional in the target cell in which the vector is used. A fourth DNA sequence encoding a negative selection marker, also functional in the target cell, is positioned 5′ to the first or 3′ to the second DNA sequence and is substantially incapable of homologous recombination with the target DNA sequence. The invention also includes transformed cells containing at least one predetermined modification of a target DNA sequence contained in the genome of the cell. In addition, the invention includes organisms such as non-human transgenic animals and plants which contain cells having predetermined modifications of a target DNA sequence in the genome of the organism.
OBJECTIVE: To explore the clinical and imaging features of nasopharyngeal cancer (NPC) complicated by acute carotid blowout syndrome (CBS), analyze the risk factors for CBS, and improve diagnostic vigilance for early intervention.
METHODS: This retrospective review was conducted between January 2003 and May 2023. Altogether, 49 patients with post-irradiation NPC with CBS and 49 patients without CBS as control group were enrolled. The condition of the patients when CBS occurred was reviewed. Patient characteristics of the CBS and control groups were compared, and binary logistic regression analysis was performed to identify risk factors for CBS.
RESULTS: All patients in the CBS group were conscious, and 41 patients had a Karnofsky performance assessment scale score of ≥ 70. After interventional therapy, 43 patients survived (the mean survival time of patients after CBS was 3.2 ± 2.1 years). Compared with the control group, the CBS group had a higher incidence of sphenoid sinusitis (81% vs. 52.4%), osteonecrosis (82.9% vs. 51.2%), artery exposure (29.3% vs. 4.9%), and internal carotid artery injury (61% vs. 29.3%). Osteonecrosis and artery exposure were selected as important risk factor for CBS, with p-values of 0.016 and 0.031, respectively.
CONCLUSION: CBS is an important factor that affects the survival of patients with NPC. If internal carotid artery injury, artery exposure, sphenoid sinusitis, and osteonecrosis are present, especially the latter two signs, the possibility of CBS should be considered.
FIELD: medicine. ^ SUBSTANCE: as antigens, vaccine contains a suspension of pure-growth cells of Str. pneumoniae streptococcus agent and rabbit viral hemorrhagic disease virus produced by selection of target affected organs of fallen rabbits from a local epizootic centre, preparation of the suspension, inoculation of a differential-diagnostic medium, recovery of agent pure growths, cultivation is carried out separately in meat-peptone broth of E. coli and glucose in the concentration of microbial cells 4-5 billion in 1 cm3 and production of 10-15 % suspensions of rabbit liver, after infection by rabbit viral hemorrhagic disease of activity 103.0 LD 50/cm3 and more, mixed in equal proportions of formalin and aluminium hydroxide in the following proportions, wt %: suspension of pure-growth cells of Str. pneumoniae streptococcus agent recovered from a local epizootic centre in a nutrient medium of titre 4-5 billion of microbial cells in 1 cm3 38.0-41.5; suspension of rabbit liver with rabbit viral hemorrhagic disease recovered from a local epizootic centre in physiologic saline of activity 103.0-4.0 LD 50/cm3 38.0-41.5; glucose 2.0-1.0; formalin 2.0-1.5; aluminium hydroxide - the rest. ^ EFFECT: higher specificity and efficacy of the vaccine. ^ 1 tbl, 5 ex
A single oral dose of Sildenafil (either 40mg or 80mg) will be administered to a participant after baseline hemodynamics are measured in the catheterization lab. Each dose will be equally distributed among those with preserved (≥50%) and reduced (\<50%) EF.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of taxane of the general formula (I)   where R 1  and R 2  mean hydrogen atoms or R 1  and R 2  in common form cyclic carbonate or cyclic thiocarbonate group of the formula (a)   or (b)  ; R 3  means hydrogen atom ; R 4  means hydrogen atom or isoserine residue of the formula (2)   where R 5  means C 1 -C 5 -alkyl group or phenyl residue; R 6  has the same values as R 5  or means tert.-butoxy-group. New derivatives of taxane show antitumor activity by inhibition of cell proliferation of normal and resistant tumor cell lines and by induction of apoptosis. These molecules have basic properties and therefore they can be administrated after salt formation in an aqueous medium without necessary use of toxicsurface-active substances. Invention describes method of their synthesis and pharmaceutical composition. EFFECT: new compounds indicated above, improved method of synthesis, valuable anti- -tumor properties. 10 cl, 1 tbl, 6 ex
Patients receive trastuzumab (Herceptin) IV over 30-90 minutes on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. It is essential to develop novel interventions to prevent/delay CVDs by targeting their fundamental cellular and molecular processes. Melatonin is a small indole molecule acting both as a hormone of the pineal gland and as a local regulator molecule in various tissues. It has multiple features that may contribute to its cardiovascular protection. Moreover, melatonin enters all cells and subcellular compartments and crosses morphophysiological barriers. Additionally, this indoleamine also serves as a safe exogenous therapeutic agent. Increasing evidence has demonstrated the beneficial effects of melatonin in preventing and improving cardiovascular risk factors. Exogenous administration of melatonin, as a result of its antioxidant and anti-inflammatory properties, has been reported to decrease blood pressure, protect against atherosclerosis, attenuate molecular and cellular damage resulting from cardiac ischemia/reperfusion, and improve the prognosis of myocardial infarction and heart failure. This review aims to summarize the beneficial effects of melatonin against these conditions, the possible protective mechanisms of melatonin, and its potential clinical applicability in CVDs.
This study was structured into two fundamental segments: 1) a dual-operator analysis focused on evaluating both intra- and inter-operator reliability of the UCA and USLA; and 2) a validation study of radiographic indices, specifically the coronal Cobb angle, TK, and LL, in correlation with UCA and USLA measurements. Initially, 100 patients diagnosed with IS were subjected to both standard radiographic and 3D ultrasound examinations. Owing to various exclusion criteria, 20 patients were subsequently disqualified from the study, resulting in a final sample of 80 patients for statistical evaluation. Reliability assessments were conducted using the Intraclass Correlation Coefficient (ICC). Furthermore, the validity of the UCA and USLA measurements was rigorously analyzed by comparing them against established radiographic benchmarks, utilizing Pearson correlation coefficients and Bland-Altman plots for comprehensive evaluation. All expected or unexpected adverse events from this study will be recorded and monitored.For comprehensive analysis, participants were systematically categorized based on multiple demographic and clinical parameters: coronal angle (either ≥20° or \<20°), gender (male or female), age (either\>14 years or ≤14 years), and nutritional status (classified as normal or abnormal).
The Roy Adaptation Model Based Empowerment Program, which consists of 12 sessions that will create awareness of social media and its effects in students and contribute to students gaining and maintaining a healthy lifestyle by providing controlled and purposeful use of social media with behavioral change, will be held with online group sessions for 12 weeks to the students in the experimental group. .
Intense movement training (practice) with the affected arm after stroke has the potential to improve upper extremity (UE) function resulting from neuroplasticity changes in the motor cortex. However, the necessary and sufficient parameters of this therapy in humans have not been fully investigated. Delineation of the most efficacious and efficient therapy for promoting UE recovery post-stroke is necessary before effective clinical implementation of this therapy. The current compared the effects on motor function impairments for three bilateral movement groups involving two doses of treatment (i.e., bilateral training coupled with neuromuscular electrical stimulation) and a sham control. During the subacute recovery phase (3 - 6 months), patients who meet motor capabilities criteria will be randomly assigned to one of three groups: (a) low intensity: 90 minutes/session, 2 sessions/week 2 weeks; bilateral movement training coupled with active neuromuscular stimulation on the impaired wrist/fingers; (b) high intensity: 90 minutes/session, 4 sessions/week for 2 weeks; bilateral movement training coupled with active stimulation on the impaired wrist/finger extensors; and (c) control group (sham active stimulation). Patients' UE motor capabilities were assessed before treatment therapy began (pretest) and within the first week after the treatment therapy ended (posttest).
Disclosed is an antibacterial agent or the like, which contains a compound having excellent antibacterial activity against drug-resistant bacteria such as MRSA and VRE. The compound has a simple structure and can be easily produced commercially at low cost. Also disclosed is a compound useful as a prodrug of the above-mentioned compound. Specifically disclosed is an antibacterial agent containing a compound (I) shown below, or a salt or prodrug thereof. Also specifically disclosed is a compound (II) shown below or a salt thereof. (In the formulae, the symbols are as defined in the description.)
Apparatus and associated methods relate to a dynamic inducement package generation system (DIPGS). In an illustrative example, the DIPGS may include at least one validated digital therapeutics (DTx), user profiles, and media profiles associated with wild media content. The DIPGS, for example, may include an assessment engine configured to generate or update a user profile based on a journal of user input and observation of user behavior. The DIPGS may include a medical media package generation engine (MMPGE) configured to generate a dynamic inducement media package (DUMP). In an inducement mode, the DUMP may play the user-selected wild media content regularly. After transitioning from the inducement mode to a therapeutic mode, the MMPGE generates an interventive monitoring content (IMC) comprising a validated DTx to provide therapeutic treatment to the user. Various embodiments may advantageously provide continuous medical guidance and progress monitoring to a user.
The invention discloses a bactericidal disinfectant, which comprises largeleaf japanese ginseng, bighead atractylodes rhizome, Chinese holly, Yedo violet, Adenosma indianum, linden viburnum, herba clerodendranthi, Picrorhiza scrophulariiflora Pennell, trifoliate-orange immature fruit, lemon eucalyptus, citronella, sugarcane juice, EM original liquid and the like. According to the technical scheme of the invention, the influence of the bactericidal disinfectant on the immune system is enhanced and the bactericidal disinfectant is more effective in improving the resistance of a human body, sterilizing, disinfecting, preventing and curing diseases and the like. largeleaf japanese ginseng and bighead atractylodes rhizome are capable of reducing the fever, nourishing the yin, replenishing the qi and invigorating the spleen, which have an effect on the function of the immune system. Chinese holly, herba clerodendranthi, Chinese violet, linden viburnum and Picrorhiza scrophulariiflora Pennell are capable of clearing away heat and toxic materials, eliminating the dampness, cooling the blood and relieving the swelling and the pain, which have antisepsis and anti-inflammation effects on a variety of pathogenic microorganisms and various bacteria. Adenosma indianum, Poncirus trifoliate, lemon eucalyptus and citronella are rich and pleasant in fragrance, and are capable of keeping away the pathogenic factor and removing the stinking smell, which have anti-inflammatory, antifungal and antiviral active ingredients. The above raw materials are combined to realize the effects of strong sterilizing and disinfecting capability, fast effect, and no toxic and side effects.
PURPOSE:To provide the titled drug containing micronomicin and beta-lactam antibiotic substance, and exhibiting synergistic effect especially to Pseudomonas aeruginosa. CONSTITUTION:The objective drug contains (A) a micronomicin compound (e.g. micronomicin) or its salt and (B) a beta-lactam antibiotic substance (e.g. piperacillin) or its salt, as active components. The micronomicin is an aminoglycoside antibiotic substance having broad antibacterial spectrum to Gram-positive bacteria and Gram-negative bacteria, especially to Pseudomonas aeruginosa. It has been found that the combination of the micronomicin with a beta-lactam antibiotic substance causes remarkable synergistic effect in the antibacterial activity especially to Pseudomonas aeruginosa. The amount of the beta-lactam antibiotic substance depends upon its kind, and is preferably 0.03-2 (W/W) for piperacillin, 0.008-32 (W/W) for cefoperazone and 0.1-16 (W/W) for latamoxef per 1pt. of micronomicin.
Breast-feeding is associated with fewer comorbidities in very-low-birth-weight (VLBW) preterm infants. Bronchopulmonary dysplasia (BPD) of VLBW infants is a multifactorial pathology in which nutritional aspects may be of special importance. The aim of this study is to determine, in a cohort of VLBW infants, whether breast milk nutrition is associated with a reduced prevalence and severity of BPD. A retrospective study was conducted to record the intake of mother's own milk (MOM), pasteurised donor human milk or preterm formula milk in the first 2 weeks of postnatal life of 566 VLBW newborns at our hospital during the period January 2008-December 2021. After applying the relevant exclusion criteria, data for 489 VLBW infants were analysed; 195 developed some degree of BPD. Moderate or severe BPD is associated with less weight gain. Moreover, the preferential ingestion of breast milk in the first and second postnatal weeks had effects associated with lower OR for BPD, which were statistically demonstrable for mild (OR 0·16; 95 % CI 0·03, 0·71) and severe (OR 0·08; 95 % CI 0·009, 0·91) BPD. Breast-feeding during the first weeks of postnatal life is associated with a reduced prevalence of BPD, which is frequently associated with less weight gain as a result of greater respiratory effort with greater energy expenditure.
Different presentations of the plant Echinacea purpurea are widely prescribed and used for the treatment of upper respiratory tract viral infections. The plant is known to contain an array of active principles including alkylamides, cichoric acid, glucoproteins resulting in stimulation of the innate immune system, in particular, an activation of macrophages and an increase of phagocytic activity (Nagoor Meeran et al. 2019. Heliyon, 7(2):e05990). It has also been recently shown to exert a direct antiviral effect against SARS-CoV-II in vitro (Signer et al. 2020. Virol J 17:136). EQUINACEA ARKOPHARMA is a pharmaceutical preparation of Echinacea purpurea prepared by controlled cryo-processing roots of the plant and packing the powder thus obtained in hard caplets. The product is a medicine approved by the European Medicines Agency for the treatment of common cold. In this study, 230 patients presenting with mild Covid-19 at the emergency room of 4 participating hospitals, with an eminently respiratory presentation, fever, and not requiring hospitalization, will be randomly assigned to two branches to receive EQUINACEA ARKOPHARMA or placebo, in a double-blind manner. Patients will be followed up for 4 weeks and the effect of treatment vs. placebo on clinical manifestations, duration of fever and of total disease and percentage of return to the emergency room and/or hospitalization will be assessed.
PURPOSE:To provide a Polynnia sonchifolia extract or Polynnia sonchifolia juice having a rich vitamin C content and a low calogie by heating the Polynnia sonchifolia juice prepared by separating residues from the skin-peeled and ground product of the Polynnia sonchifolia at a temperature below the boiling point of the juice and simultaneously removing the harshness thereof, adding salt and a discoloration-preventing agent to the treated juice, again subjecting to the harshness removing treatment, purifying and subsequently sterilizing the juice. CONSTITUTION:Residues are removed from a Polynnia sonchifolia juice prepared by subjecting the Polynnia sonchifolia (produced in the South America) to skin-peeling and grinding treatments. The prepared Polynnia sonchifolia juice alone is heated below the boiling point thereof, preferably below 100 deg.C, simultaneously subjected to a harshness-removing treatment and further repeatedly subjected to the harshness-removing treatment preferably 5-10 times. The Polynnia sonchifolia juice subjected to the harshness-removing treatment is simultaneously or successively mixed with salt and a discoloration-preventing agent and/or an organic acid and subsequently boiled. The heating temperature is simultaneously adjusted and the harshness boiled up is instantaneously removed, followed by repeating the process. After purified with natural pulp filtration paper, etc., the prepared Polynnia sonchifolia juice is heated for a sterilization treatment to provide a Polynnia sonchifolia extracts or Polynnia sonchifolia extract.
Children in the HF group receive oxygen via high flow nasal cannula during deep sedation. Fraction of inspired oxygen is set to 50%.
Morbidity and mortality in heart failure (HF) patients remain high, even with recent advances in therapies. Previous studies have shown that the autonomic nervous system plays an important role in the pathophysiology of HF and sudden cardiac death.

Spinal cord stimulation (SCS) is a neurostimulation therapy, which involves the stimulation of selected nerve fibers and intends to create end-organ responses characterized by changes in blood flow, decrease of catecholamines and reduction in inflammation. The SCS system consists of an implantable pulse generator (IPG) and dual leads. Each lead has electrodes on the distal end. Electrical impulses travel from the IPG through the leads to the electrodes positioned at the selected nerve fibers to provide the therapeutic stimulation. By virtue of its potential in augmenting blood flow, decreasing catecholamines and reducing inflammation, SCS may benefit HF patients.
This invention is concerned with novel dual acting anti-tumor drugs. These dual acting anti-tumor drugs comprise at least two moieties. One of the moieties can be an agent that stimulates the differentiation of tumor cells. Examples of the moiety includes butanoyl and retinoyl groups. Another moiety is a hydroxy-containing anti-tumor agent.  Examples of the hydroxy-containing anti-tumor agent are nucleoside analogs, steroids having anti-tumor activity and anthracyclines. Also disclosed, are methods of using the dual acting anti-tumor drugs to prevent or treat a tumor and a process of making these drugs.
Because COVID triggered elevated rates of child abuse, but diminished rates of child abuse reporting, we explored predictors of nurses' attitudes toward reporting suspected child abuse during the COVID pandemic. In particular, we expected that compassion fatigue and compassion satisfaction would mediate the effects of COVID-related stressors (i.e., exposure to COVID patient death and suffering; COVID-related family income loss; frequent direct care of COVID patients; and parental burnout) on nurses' negative attitudes toward reporting suspected child abuse. Employing chain-referral sampling, we recruited a sample of 244 registered nurses (83% White; 87% women). Supporting hypotheses, compassion fatigue mediated the effects of job-related COVID stressors (exposure to COVID patient death and suffering; COVID-related family income loss; and frequent direct care of COVID patients) on nurses' negative attitudes toward reporting suspected child abuse. In addition, among nurses who were also parents, nurses' self-reported parental burnout mediated the relation between compassion fatigue and negative attitudes toward reporting suspected child abuse. In addition, compassion satisfaction mediated the effect of nurses' parental burnout on nurses' negative attitudes toward reporting suspected child abuse.
The investigators will provide exercise dose recommendations for initial visit until symptom resolution, and revise upon symptom resolution (to use for the subsequent 8 weeks). These include intensity (target HR) and volume (frequency/duration). Intensity is calculated as 90% of the HR at the end of the exercise test. The volume recommendation is 150 mins/week (\~30 min/day; 5 days/week). The mode of exercise is another consideration. This will be left to participant preference, so that the investigators do not exclude potential participants due to lack of access to specific exercise equipment.
Clinical anatomy education is meant to prepare students for caring for the living, often by working with the dead. By their nature many clinical anatomy education programs privilege topographical form  over the donor's humanity. This inbalance between the living and the dead generates tensions between the tangible and the spiritual insofar as semblances of the humanity of donors endure even in depictions and derivatives. This article argues that considering the relevance of spirituality, and what endures of a donor's humanity after death, would enhance contemporary anatomy education and the ethical treatment of human body donors (and derivatives). In developing this argument, we (the authors) address the historical connection between spirituality and anatomy, including the anatomical locations of the soul. This serves as a basis for examining the role of the mimetic-or imitative-potential of deceased human donors as representations of the living. We deliberate on the ways in which the depersonalization and anonymization of those donating challenge the mimetic purpose of human body donors and the extent to which such practices are misaligned with the health care shift  from a biomedical to a biopsychosocial model. Weighing up the risks and opportunities of anonymization versus personalization of human body donors, we propose curricula that could serve to enhance the personalization of human donors to support students learning topographical form. In doing so, we argue that the personalization of human donors and depictions could prevent the ill effects of digital representations going "viral," and enhance opportunities for donors to help the general public learn more about the human form.