anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Hantaan virus (HTNV) is asymptomatically carried by rodents, yet causes lethal hemorrhagic fever with renal syndrome in humans, the underlying mechanisms of which remain to be elucidated. Here, we show that differential macrophage responses may determine disparate infection outcomes. In mice, late-phase inactivation of inflammatory macrophage prevents cytokine storm syndrome that usually occurs in HTNV-infected patients. This is attained by elaborate crosstalk between Notch and NF-κB pathways. Mechanistically, Notch receptors activated by HTNV enhance NF-κB signaling by recruiting IKKβ and p65, promoting inflammatory macrophage polarization in both species. However, in mice rather than humans, Notch-mediated inflammation is timely restrained by a series of murine-specific long noncoding RNAs transcribed by the Notch pathway in a negative feedback manner. Among them, the lnc-ip65 detaches p65 from the Notch receptor and inhibits p65 phosphorylation, rewiring macrophages from the pro-inflammation to the pro-resolution phenotype. Genetic ablation of lnc-ip65 leads to destructive HTNV infection in mice. Thus, our findings reveal an immune-braking function of murine noncoding RNAs, offering a special therapeutic strategy for HTNV infection.
Patients should be instructed that the expected benefits of alendronate sodium may only be obtained when it is taken with plain water the first thing upon arising for the day at least 30 minutes before the first food, beverage, or medication of the day. Even dosing with orange juice or coffee has been shown to markedly reduce the absorption of alendronate sodium (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Absorption). 

To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation patients should be instructed to swallow each tablet of alendronate sodium with a full glass of water (6 to 8 oz). Patients should be instructed not to lie down for at least 30 minutes and until after their first food of the day. Patients should not chew or suck on the tablet because of a potential for oropharyngeal ulceration. Patients should be specifically instructed not to take alendronate sodium at bedtime or before arising for the day. Patients should be informed that failure to follow these instructions may increase their risk of esophageal problems. Patients should be instructed that if they develop symptoms of esophageal disease (such as difficulty or pain upon swallowing, retrosternal pain or new or worsening heartburn) they should stop taking alendronate sodium and consult their physician. 

Patients should be instructed that if they miss a dose of once weekly alendronate sodium, they should take one dose on the morning after they remember. They should not take two doses on the same day but should return to taking one dose once a week, as originally scheduled on their chosen day.
Chronic obstructive pulmonary disease (COPD) is a significant preventable and treatable clinical disorder defined by a persistent, typically progressive airflow obstruction. This disease has a significant negative impact on mortality and morbidity worldwide. However, the complex interaction between the heart and lungs is usually underestimated, necessitating more attention to improve clinical outcomes and prognosis. Indeed, COPD significantly impacts ventricular function, right and left chamber architecture, tricuspid valve functionality, and pulmonary blood vessels. Accordingly, more emphasis should be paid to their diagnosis since cardiac alterations may occur very early before COPD progresses and generate pulmonary hypertension (PH). Echocardiography enables a quick, noninvasive, portable, and accurate assessment of such changes. Indeed, recent advancements in imaging technology have improved the characterization of the heart chambers and made it possible to investigate the association between a few cardiac function indexes and clinical and functional aspects of COPD. This review aims to describe the intricate relation between COPD and heart changes and provide basic and advanced echocardiographic methods to detect early right ventricular and left ventricular morphologic alterations and early systolic and diastolic dysfunction. In addition, it is crucial to comprehend the clinical and prognostic significance of functional tricuspid regurgitation in COPD and PH and the currently available transcatheter therapeutic approaches for its treatment. Moreover, it is also essential to assess noninvasively PH and pulmonary resistance in patients with COPD by applying new echocardiographic parameters. In conclusion, echocardiography should be used more frequently in assessing patients with COPD because it may aid in discovering previously unrecognized heart abnormalities and selecting the most appropriate treatment to improve the patient's symptoms, quality of life, and survival.
FIELD: veterinary science. SUBSTANCE: preparation has, mg/ml: histamine, 0.00005-0.0001; copolymer of vinylpyrrolidone and organic acid as a carrier, 0.00154-0.0611; and solvent, the balance. Solvent: physiological solution or its mixture with oily adjuvant at ratio = 1:1, or with 3-5% an aqueous suspension of silica at ratio 1:1. Preparation is prepared by conjugation of histamine with an organic acid link in composition of copolymer with vinylpyrrolidone. For prophylaxis preparation is injected to animals by intramuscular route: to piglets 7-10 days before weakling at volume 1-2 ml (one dose), 14-20 days before weakling at 6-8 days interval at volume 1-2 ml per each injection; to calves - at volume 2-3 ml to one day newborns. Preparation is used for nonspecific immunostimulating prophylaxis of allergotoxicosis in piglets and calves. EFFECT: improved preparation stability, enhanced effectiveness of prophylaxis, simplified procedure. 10 cl, 23 tbl
PROBLEM TO BE SOLVED: To provide a perfect human anti-human TfR antibody specifically recognizing a human transferrin receptor (TfR), inhibiting survival and proliferation of a TfR highly expressing cancer cell, and having no immunogenicity against human.SOLUTION: An antibody specifically reacts with human TfR comprising a certain amino acid sequence respectively as a heavy chain first complementarity determining region (VH CDR1), a heavy chain second complementarity determining region (VH CDR2) or a heavy chain third complementarity determining region (VH CDR3). A DNA codes the antibody. A recombinant vector contains the DNA. A transformant induces the vector. A production method of the antibody cultures the transformant. A pharmaceutical composition has the antibody.
FIELD: medicine. SUBSTANCE: method involves applying sodium hypochlorite and 17% aqueous solution of sodium ethylenediamine tetracetate activated with ultrasonic radiation for preparing root canals. Then, local antibacterial therapy is applied by introducing mixture composed of metronidazole, cyprofloxacin and minocycline taken in equal weight proportions. Calcium hydroxide is introduced into the canals for stimulating reparative processes. EFFECT: enhanced effectiveness of prophylaxis and treatment of functional scoliosis cases. 18 dwg, 2 tbl
NEW MATERIAL:The compound of formula (R1 is 8-20C long-chain alkyl or alkenyl; R2 is the side chain of the constituent amino acid of polypeptide derived from keratin; n is 3-20; M is H, alkali metal such as Na, K, etc., ammonium, or onium of organic alkanolamine such as monoethanolamine) and its salt. USE:An additive for hair cosmetic. It has surface active properties in contrast with a keratin-derived polypeptide. It has extremely low irritation to the skin and mucosa, and has very mild action. PROCESS:The compound of formula can be prepared by hydrolyzing keratin (e.g. animal hair, hair, feather, nail, wool, etc.) with an acid such as hydrochloric acid, sulfuric acid, etc., an alkali such as NaOH, KOH, etc. or an acidic proteinase such as pepsin, proctase A, etc., and reacting the resultant aqueous solution with the acid chloride derivative of the higher fatty acid to be condensed, under alkaline condition.
This study addresses a critical gap in quality of care for Veterans with heart failure (HF). Only 1/3 or fewer eligible Veterans are receiving SGLT2 inhibitors and mineralocorticoid receptor antagonists, both medications that save lives and prevents HF hospitalizations. The investigators will combine insights from behavioral science and quality improvement science to create two types of 'nudges' - informational alerts and peer comparison feedback - to increase prescribing of these medications. The investigators will create two types of 'nudges' - informational alerts and peer comparison feedback - to increase prescribing of these medications. The investigators will compare the effect of these two nudge strategies alone and in combination compared to usual care. This project will develop simple, scalable, and low-cost strategies to improve the health of Veterans with HF.
An automatic stimulator with a section of approximately 0.35 mm in diameter and with a blunt tip was developed to apply this type of stimulus. This stimulator has a calibrated spring, which allows force to be gradually applied, while providing a safety margin to avoid accidents during tests. This allows two types of measurements to be made depending on the speed with which the stimulus is applied.
Disclosed and claimed are nucleotides for genes encoding the canine herpesvi rus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which are also disclosed and claimed. The genes are useful as DNA probes or, for preparing PCR primers. The polypeptides are useful in antigen ic, immunological or vaccine compositions. The nucleotid es can be expressed in any suitable vector system, allowing for production of t he polypeptides. Additionally, the vector system contain ing any or any combination of the nucleotides can be employed in an antigenic, immun ological or vaccine composition, such as a poxvirus vect or system, e.g., a CHV-vaccinia or avipox virus recombinant, as can the product s from expression, i.e., the gB, gC and gD glycoproteins . Antibodies elicited by the glycoproteins or from expression of the vector co ntaining the nucleotide (s) are also useful. Methods for making and using the composition are also disclosed and claimed. Also, specific can arypox-CHV gB, gC and gD recombinant vCP 320, vCP322 and vCP294 and methods for making and using them are also disclosed and clai med.
In order to evaluate the usability of the 1 MSTS, the validity and reliability of the test will be examined. In order to determine its validity in assessing physical capacity, the correlation of 1 minute sit up and 6 MWT and quadriceps muscle strength; In order to determine its validity in the evaluation of effort-induced desaturation, the correlation between the change in oxygen saturation and heart rate parameters before and after the 6 MWT and the change before and after the 1 MSTS test will be examined. In order to determine the reliability of the 1 MSTS, a re-test will be performed and 1 MSTS will be applied again after 1 week and the intraclass correlation coefficient will be checked.
This is a Phase I, open-label, non-randomized, single center study in 48 healthy adult male and female subjects, aged 18 to 45 years. This study is aimed to investigate the safety and pharmacokinetics of ceftazidime-avibactam (AVYCAZ) combined with aztreonam (ATM), AVYCAZ alone, and ATM alone. The study will have 6 arms, arms 1-4 are the single drug administration treatment groups and will include AVYCAZ per label dosing, AVYCAZ as a continuous infusion (CI), ATM per label dosing, and ATM as a continuous infusion (CI). Arms 5 and 6 are the two AVYCAZ and ATM combination drug administration treatment groups. The duration of subject participation will be up to 44 days, and the total length of the study will be 15 months. The primary objective of this study is to describe the safety of two dosing regimens of AVYCAZ combined with ATM relative to AVYCAZ alone, and ATM alone in healthy adult subjects. The secondary objectives of this study are to; 1) Characterize the PK profiles of two dosing regimens of AVYCAZ combined with ATM, AVYCAZ alone, and ATM alone at the population level in healthy adult subjects; 2) Characterize the PK profiles of two dosing regimens of AVYCAZ combined with ATM, AVYCAZ alone, and ATM alone following initiation of dosing on day 1 in healthy adult subjects; and 3) Characterize the PK profiles of two dosing regimens of AVYCAZ combined with ATM, AVYCAZ alone, and ATM alone following multiple daily dosing in healthy adult subjects.
PROBLEM TO BE SOLVED: To save the labor and time of exchanging information regarding a radiogram interpretation request when a hospital makes the request to a radiogram interpretation ASP on the outside. SOLUTION: In a radiogram interpretation service providing system, an information keeping ASP 12, an information processing ASP 13, the radiogram interpretation ASP 14 and a service coordinator 15 are players. By the ASPs 12 and 13, an electronic coupon for indicating the right to utilize the service of information processings and information keeping is issued to the hospital. The coordinator 15 is interposed between the hospital 11 and the radiogram interpretation ASP 14 and delivers the electronic coupon to the radiogram interpretation ASP 14 after performing a required processing to it. The radiogram interpretation ASP 14 uses the electronic coupon, acquires images from the ASP 12 and also makes the ASP 13 perform the information processing.  The radiogram interpretation of the images is performed in the ASP 14 and the radiogram interpretation result is sent through the coordinator 14 to the hospital. The service fee of the ASPs 12-14 are billed to the coordinator 14 altogether.
The lip-splitting approach enables excellent access to all areas of the mouth and pharynx to remove tumors; however, traditional lower lip-splitting incisions produce an unsatisfactory scar. To achieve better functional and aesthetic results, we used a Z-shaped incision and compared the functional and aesthetic outcomes of the straight and Z-shaped incisions. Sixty patients who fulfilled the inclusion criteria were randomly divided into two groups and underwent lip-splitting between March 2021 and September 2023. Eventually, 77 patients were reviewed within 6 months and evaluated using the lip function assessment scale, patient and observer scar assessment scale, naïve observer scar assessment scale, and a clinical examination. The Z-shaped incision group performed better in terms of the lip pout movement at 3 months and in the subjective overall opinion, color, irregularity, and pigmentation at 6 months. The Z-shaped incision group had a lower incidence of notched vermilion. In conclusion, Z-shaped lower lip-splitting incisions have better functional and aesthetic outcomes than traditional straight incisions.Trial registration: Public title: Difference between the effect of Z-shaped and vertical incisions of labiobuccal flap on the recovery of lower lip scars. Registration date: 09/03/2021. Registration number: ChiCTR2100044084. Registry URL: http://www.chictr.org.cn .
Adaptive 12-week text message intervention using reinforcement learning to increase whole grain and reduce refined grain intake. Participants will also complete semi-structured follow-up interviews and study related questionnaires.
The present invention, in an exemplary embodiment, provides a stent, which combines many of the excellent characteristics of both silicone and metal stents while eliminating the undesirable ones. In particular, it is an objective of a preferred embodiment of the present invention to provide a stent that is easily installed, yet removable. Moreover, the stent does not cause material infections and has the capacity to reduce infection. Therefore, a principal objective of a preferred embodiment in accordance with the present invention is to provide a prosthesis that is suitable for both permanent and temporary use while being easy to insert, reposition and remove. This prosthesis is also suitable for targeted delivery of antimicrobial and chemotherapeutic agents. Additionally, a principal objective in accordance with the present invention is to provide a family of stents where the relative hardness/softness of regions of the stent can differ from other regions of the stent to provide additional patient comfort and resistance to radial forces. An exemplary embodiment also provides a family of stents with novel interstice configurations that facilitate flexibility, durability and/or proper installation.
Patients receive placebo PO QD for 4-10 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo radical prostatectomy between days 28-70.
Patients undergo observation on weeks 1-12. Patients then receive bicalutamide PO QD on weeks 13-44. Patients with a PSA decline of \>= 50% may continue on bicalutamide until week 72 in the absence of disease progression or unacceptable toxicity.
The invention discloses a traditional Chinese medicine preparation used for treating liver Qi stasis chronic pancreatitis. Chronic pancreatitis belongs to disease category of stomachache, hypochondriac pain, and mass in the abdomen accumulation in traditional Chinese medicine. Symptoms of chronic pancreatitis are malfunctions of liver, gallbladder, spleen, and stomach caused by a plurality of factors, qi movement blocking, blood stasis and collaterals blocking, weak spleen Qi, and dysfunction of the spleen in transport. The traditional Chinese medicine preparation is prepared by subjecting Parmelia saxatilis Ach., Mucuna sempervirens Hemsl., Rubia yunnanensis (Franch.) Dlels, Limonium bicolor, Haenaria davidii Franch., medicated leaven, Peperomia dindigulensis Miq., Fructus Polygoni Orientalis, Chinese fevervine herb, Lespedeza cuneata, liquorice, and semen cuscutae. It is confirmed by clinical experiment that total effective ratio is 97.5%, and no side effect is caused.
Eukaryotic gene expression is linked to chromatin structure and nucleosome positioning by ATP-dependent chromatin remodelers that establish and maintain nucleosome-depleted regions (NDRs) near transcription start sites. Conserved yeast RSC and ISW2 remodelers exert antagonistic effects on nucleosomes flanking NDRs, but the temporal dynamics of remodeler search, engagement, and directional nucleosome mobilization for promoter accessibility are unknown. Using optical tweezers and two-color single-particle imaging, we investigated the Brownian diffusion of RSC and ISW2 on free DNA and sparse nucleosome arrays. RSC and ISW2 rapidly scan DNA by one-dimensional hopping and sliding, respectively, with dynamic collisions between remodelers followed by recoil or apparent co-diffusion. Static nucleosomes block remodeler diffusion resulting in remodeler recoil or sequestration. Remarkably, both RSC and ISW2 use ATP hydrolysis to translocate mono-nucleosomes processively at ~30 bp/s on extended linear DNA under tension. Processivity and opposing push-pull directionalities of nucleosome translocation shown by RSC and ISW2 shape the distinctive landscape of promoter chromatin.
PROBLEM TO BE SOLVED: To obtain a preventive for wrinkle formation, capable of preventing and improving the occurrence of wrinkle caused by aging of skin by including a metal-dependent elastin decomposing inhibitor as an active ingredient. SOLUTION: This medicine comprises a metal-dependent elastin decomposing inhibitor, especially a metal-dependent elastin decomposing inhibitor derived from a fibroblast of corium, such as a phosphonic acid derivative or a mercaptopropionamide derivative as an active ingredient. The medicine is further formulated with an ultraviolet absorber or an ultraviolet controller to preferably prepare a skin preparation for external use. The formulated amount of the metal-dependent elastin decomposing enzyme inhibitor in the case of preparing the skin preparation for external use is preferably 0.0001-5 wt.% based on the whole composition. The elastin decomposing enzyme includes one belonging to a serine protease and one belonging to a metal-dependent protease. An elastase inhibitor belonging to the metal protease has excellent controlling action on wrinkle formation.
Subjects between ages 50 and 84 identified to have CRC. Blood and stool specimens are collected and tested after colonoscopy and prior to surgery or other interventions.
BACKGROUND: Rectal neuroendocrine tumours (rNETs) are rare but are increasing in incidence. Current management and surveillance recommendations are based on low-grade evidence. Follow-up practices are often inconsistent and costly. This retrospective study analyses a single-centre's experience with rNETs to assess incidence, management practices, outcomes, and guideline adherence.
METHODS: This is a single-centre retrospective study from Queensland Australia, spanning from 2012 to 2023. Twenty-eight rNET cases met inclusion criteria. Examined parameters included incidence, management, outcomes and adherence to European Neuroendocrine Tumour Society (ENETS) guidelines. R1 resection rate was analysed for associations with resection technique and lesion recognition and recurrence rate was assessed in all patients.
RESULTS: This study shows an increasing incidence of rNETs during the study period, reflecting a global trend. R1 resection rate at initial endoscopy was 75%. There was a general lack of advanced endoscopic techniques utilized and poor lesion recognition, however a statistically significant correlation was not established between these factors and an R1 result (P < 0.05). Most patients with an R1 result had subsequent re-resection to render the result R0, however five patients (33%) underwent surveillance with no reports of recurrence on follow-up. Overall, follow-up practices in our cohort were inconsistent and did not adhere to guidelines.
CONCLUSION: rNETs are increasing in incidence, emphasizing the need for standardized management and surveillance. Further training is required for rNET recognition and advanced endoscopic resection techniques. Further research is required to assess long-term outcomes in surveilled R1 cases, understand optimal endoscopic resection techniques and further develop local surveillance guidelines.
A home exercise program consisting of traditional training exercises as well as separate exercises focusing on core and lower limb training will be performed during 6 weeks (4 sessions/week). To monitor progress and control load progression, a physical therapist will visit the subject every week.
Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation into pro-inflammatory macrophages. Therefore, whether blocking inflammatory monocytes can mitigate disease progression is being actively evaluated. Here, we employ multiple lineage-tracing models and show that monocyte-derived macrophages (mo-mac) are the major population of immunosuppressive, liver metastasis-associated macrophages (LMAM), while the proportion of Kupffer cells (KC) as liver-resident macrophages is diminished in metastatic nodules. Paradoxically, genetic ablation of mo-macs results in only a marginal decrease in LMAMs. Using a proliferation-recording system and a KC-tracing model in a monocyte-deficient background, we find that LMAMs can be replenished either via increased local macrophage proliferation or by promoting KC infiltration. In the latter regard, KCs undergo transient proliferation and exhibit substantial phenotypic and functional alterations through epigenetic reprogramming following the vacating of macrophage niches by monocyte depletion. Our data thus suggest that a simultaneous blockade of monocyte recruitment and macrophage proliferation may effectively target immunosuppressive myelopoiesis and reprogram the microenvironment towards an immunostimulatory state.
Patients receive gefitinib PO QD for 7 weeks. Beginning 1 week after initiation of gefitinib, patients undergo radiation therapy QD 5 days a week for 6 weeks. Treatment with gefitinib continues for up to 18 months in the absence of disease progression or unacceptable toxicity.