anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Perform regular care for eight consecutive weeks. After the tracking period ends (8 weeks), provide home-based education on resistance exercises, cardiovascular endurance exercises, and sensory training exercises.
Atopic dermatitis (AD), a prevalent chronic inflammatory disease with multifactorial etiology, features epidermal barrier defects and immune overactivation. Synthetic glucocorticoids (GCs) are widely prescribed for treating AD due to their anti-inflammatory actions; however, mechanisms are incompletely understood. Defective local GC signaling due to decreased production of endogenous ligand and/or GC receptor (GR) levels was reported in prevalent inflammatory skin disorders; whether this is a consequence or contributing factor to AD pathology is unclear. To identify the chromatin-bound cell-type-specific GR protein interactome in keratinocytes, we used rapid immunoprecipitation of endogenous proteins and mass spectrometry identifying 145 interactors that increased upon dexamethasone treatment. GR-interacting proteins were enriched in p53/p63 signaling, including epidermal transcription factors with critical roles in AD pathology. Previous analyses indicating mirrored AD-like phenotypes between P63 overexpression and GR loss in epidermis, and our data show an intricate relationship between these transcription factors in human keratinocytes, identifying TP63 as a direct GR target. Dexamethasone treatment counteracted transcriptional up-regulation of inflammatory markers by IL4/IL13, known to mimic AD, causing opposite shifts in GR and P63 genomic binding. Indeed, IL4/IL13 decreased GR and increased P63 levels in cultured keratinocytes and human epidermal equivalents (HEE), consistent with GR down-regulation and increased P63 expression in AD lesions vs normal skin. Moreover, GR knockdown (GRKD) resulted in constitutive increases in P63, phospho-P38 and S100A9, IL6, and IL33. Also, GRKD culture supernatants showed increased autocrine production of TH2-/TH1-/TH17-TH22-associated factors including IL4, CXCL10, CXCL11, and CXCL8. GRKD HEEs showed AD-like features including hyperplasia and abnormal differentiation, resembling phenotypes observed with GR antagonist or IL4/IL13 treatment. The simultaneous GR/P63 knockdown partially reversed constitutive up-regulation of inflammatory genes in GRKD. In summary, our data support a causative role for GR loss in AD pathogenesis via functional interactions with P63 and autocrine signaling in epidermal keratinocytes.
Functional Connectivity will be measured by MRI, we will perform one T1WI run as well as three resting state bold based runs. Bold runs parameters: TE 30ms, TR 3000ms, flip angle 90º, gap 0mm, 124 time points, voxel size 3mm, duration 6min18s each, FOV 240x240x141.
The invention relates to the technical field of tea bag beverages, in particular to a pressure-reducing tea bag and a preparing method and application thereof. According to the formula, a pressure-reducing composite comprises, by weight, 1-3 parts of hawthorn, 0.2-0.5 part of prunella vulgaris, 0.3-0.8 part of chrysanthemum, 0.3-0.8 part of common cephalanoplos herb, 0.2-0.5 part of rhizoma alismatis and 0.3-0.8 part of semen cassiae. The method for preparing the pressure-reducing tea bag according to the formula includes the steps that composite raw materials are preprocessed; pelletizing and drying are conducted; particles are tidied and totally blended, totally-blended medicine powder is packaged in a split mode, and the tea bag is prepared. The appearance of the pressure-reducing tea bag is yellowish-brown particles, the smell is slightly fragrant, the taste is sour and good, and the tea bag is easy to carry. The tea bag has the effects of whetting the appetite, promoting circulation and removing stasis, clearing away heat and improving eyesight, achieving diuresis, protecting the liver, resisting ageing and cancers, softening blood vessels, preventing and treating cardiovascular diseases, preventing hyperlipidemia, reducing blood pressure and cholesterol and the like. People can be full of spirit and energy after drinking tea into the stomach, the tea bag is naturally made, and the tea bag is free of any additive, pigments and other components and is a green beverage.
PURPOSE:To obtain a root canal filling material having excellent root canal filling property, safety of the structure and operating property, etc., by dissolving an amorphous fluorine-containing polymer in an acrylic monomer, adding a X ray contrast medium and polymerization initiator thereto and polymerizing the fluorine-containing polymer with the acrylic monomer. CONSTITUTION:An amorphous fluorine-containing polymer is dissolved in an acrylic monomer at a polymerization ratio of 30-60:40-70 and X ray contrast medium (e.g. ZrO2 or BaSO4) and polymerization initiator (e.g. benzoyl peroxide and diethanol p-toluidine) are added thereto and the fluorine-containing polymer is polymerized with the acrylic monomer to produce the root canal filling material. The above-mentioned fluorine-containing polymer includes preferably a vinylidene fluoride based copolymer in which I atom or Br atom is bonded to the polymer chain. The title material can be obtained by blending the polymerization initiator with the blend of each ingredient excluding the polymerization initiator just before using.
Conservative treatment of peritoneal carcinomatosis with malignant ascites (PCMA) is based on chemoinfusion with its inherent toxicity. There is a strong demand for a safe and non-toxic method of treatment of PCMA. The new technology of modulated electro-hyperthermia (mEHT) has proven efficacy in many advanced cancers with minimal side effects and synergy with Traditional Chinese Medicine (TCM). TCM has a long history of application at advanced cancer as a symptomatic treatment and enhancer of the general resistance of the organism. Shi Pi Decoction is supposed to be the optimum co-treatment of PCMA according to principles of TCM. Intraperitoneal chemoinfusion (IPCI) with cisplatin and fluorouracil is a widespread standard treatment of PCMA in China. This randomized II phase trial studies efficacy and safety of combination of mEHT with TCM in treatment of PCMA versus standard IPCI (CDDP+5FU).
Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whether pulmonary epithelial cell senescence is involved in the process remain elusive. In this study, PQ-induced pulmonary epithelial cell senescence and Hippo-YAP/TAZ activation were observed in both C57BL/6 mice and human epithelial cells. PQ-induced senescent pulmonary epithelial cells promoted lung fibroblast transformation through secreting senescence-associated secretory phenotype (SASP) factors. Yap/Taz knockdown in mice lungs significantly decreased the expression of downstream profibrotic protein Ctgf and senescent markers p16 and p21, and alleviated PQ-induced pulmonary fibrosis. Interfering YAP/TAZ in senescent human pulmonary epithelial cells resulted in decreased expression of the anti-apoptosis protein survivin and elevated level of apoptosis. In conclusion, our findings reveal a novel mechanism by which the involvement of Hippo-YAP/TAZ activation in pulmonary epithelial cell senescence mediates the pathogenesis of PQ-induced pulmonary fibrosis, thereby offering novel insights and potential targets for the clinical management of PQ poisoning as well as providing the mechanistic insight of the involvement of Yap/Taz activation in cell senescence in pulmonary fibrosis and its related pulmonary disorders. The YIN YANG balance between cell senescence and apoptosis is important to maintain the homeostasis of the lung, the disruption of which will lead to disease.
FIELD: medicine, narcology. SUBSTANCE: invention relates to biologically active additions used for arresting and treatment of patients with alcohol withdrawal syndrome and for prophylaxis and treatment of alcoholics. Kit has the complex of antialcoholic agents for solution of problem associated with negative effect of alcohol on human body. Kit has an antialcoholic agent for removal of postintoxication syndrome in acute alcoholic intoxication and the second antialcoholic agent for removal of psychoemotion stress syndrome in chronic alcoholism. Kit of antialcoholic agents does not show toxicity and an be used for prophylaxis and treatment of patients with psychoemotion stress or chronic psychic stress. EFFECT: enhanced effectiveness of kit. 3 cl, 1 tbl, 7 ex
PURPOSE: To obtain an ultraviolet light controlling agent having excellent ultraviolet light screening effect, comprising a swelling lamellar silicate mineral containing a specific amount of iron in a crystal structure and between layers and to provide a cosmetic containing the ultraviolet light controlling agent. CONSTITUTION: This ultraviolet light controlling agent comprises a swelling lamellar silicate mineral which contains at least 7wt.%, preferably >=10wt.% calculated as ferric oxide of iron in a crystal structure and between layers and has <=50μm particle diameter alone or a mixture of two or more of swelling lamellar silicate minerals. The swelling lamellar silicate mineral is obtained by sieving a natural swelling lamellar silicate mineral with water and bentonite may be cited as the swelling lamellar silicate mineral. The ultraviolet light controlling agent comprising the swelling lamellar silicate mineral is used an active ingredient and an anti-suntan cosmetic containing 0.05-50wt.% of the ultraviolet light controlling agent can be prepared.  The ultraviolet light controlling agent is fine particles, has excellent dispersibility, has chemical stability, is hardly denatured, has swelling properties and thickening action. The ultraviolet light controlling agent having uniform particle diameters and shapes of particles is obtained at a low cost.
There are currently no FDA-approved medications indicated for the treatment of AD. While inflammation is pervasive to many neurological disorders, no clinical trial has yet demonstrated the efficacy of anti-inflammatory agents for AD. Interestingly, chronic peripheral low-grade inflammation is associated with aging and increases the risk for disease and mortality, including AD. Accumulating evidence indicates that nuclear factor-kappa B, tumor necrosis factor alpha (TNFα), interleukins (e.g. IL-1beta, IL-2, and IL-6), and chemokines (e.g. IL-8) are found elevated both in the blood and central nervous system (CNS) of AD patients. These data confirm that inflammation plays a central role in the cause and effect of AD neuropathology.

The immunomodulator, anti-cancer agent lenalidomide is one of the very few pleiotropic agents that both lowers the expression of TNFα, IL-6, IL-8, and increases the expression of anti-inflammatory cytokines (e.g. IL-10), to modulate both innate and adaptive immune responses. In the current project we aim to test the central hypothesis that lenalidomide reduces inflammatory and AD-associated pathological biomarkers in the blood and CSF. For this, we designed a 6-month, Phase II, double blind, randomized, two-armed, parallel group, placebo controlled, and proof-of-mechanism clinical study in early symptomatic AD subjects (i.e. amnestic mild cognitive impairment; aMCI). The effects of lenalidomide treatment will be assessed continuously for 26 weeks and 4 weeks washout (total of 30 weeks).
In the LVT group, LVT via the Hypervolt™ (HYPERICE Inc, US) vibrating massage device will be added to Standard Physiotherapy Program. This device gives vibration with five different speed settings, vibrating at 3,200 percussions per minute. There are five different head options. The ball head attachment was chosen as it is the least aggressive option and the vibration from the device will be applied to the relevant muscle body. For the facilitator effect, high frequency application will be made to the lower trapezius and serratus anterior muscles. For the inhibitory effect, the upper trapezius, deltoid, pectoralis minor, and supraspinatus muscles will be applied at low frequency. The application will be 5 minutes for each muscle, for a total of 30 minutes. During the application, the speed will be controlled with a metronome, the travel time along the body of the relevant muscle will be 10 seconds, and the return time to the starting point will be 10 seconds.
ESC-PTP is calculated using age, sex and type of chest pain according to 2019 ESC guideline for the diagnosis and management of CCS and RF-CL is calculated using age, sex, type of chest pain, hypertension, dyslipidemia, diabetes, smoking and family history of CAD based on the publication of Winther et al., respectively. According to ESC strategy, subjects with ESC-PTP ≤5% are classified into low risk group and ones with ESC-PTP ≥15% are classified into high risk group. For subjects with ESC-PTP of 5%-15%, ones with RF-CL ≥15% are classified into high risk group and ones with RF-CL \<15% are classified into low risk group. CCTA should be referred for a subject in high risk group. Subjects determined to be at low risk will be referred to optimal medication treatment with no immediate CCTA.
Cataract surgery is a widely performed procedure across the world that helps restore vision in many patients suffering from cataracts. The surgery has known many improvements across time and continues to do so. Irrigation is an essential component of the surgery. Fluid is constantly being circulated to help regulate temperature as heat is generated with the use of ultrasound energy, to minimize tissue trauma, and to create an intraocular pressure sufficient to keep the anterior chamber stable. In parallel, aspiration brings the components of the cataract closer to the surgical instrument. A balance between irrigation and aspiration during surgery is essential to maintain stability in the anterior chamber. However, an ideal flow rate, which influences intraocular pressure (IOP) during surgery, is yet to be determined. Most recent studies with Centurion Active Sentry (maintaining vacuum and aspiration rates the same) show that there is similar efficiency between higher and lower IOP settings. Traditionally, high-flow rates have been used in advanced cataracts and are believed to increase the space in the anterior chamber. However, they are known to create fluid turbulence and are associated with risks of tissue damage, including cell loss in the endothelial layer of the cornea. High intra-ocular pressure during surgery has also been shown to cause damage to the optic nerve as well as to the retina. Distorting and stretching the anterior chamber during phacoemulsification have also been associated with increased pain experienced by the patient. Comfort can be achieved by lowering pressure levels. Low-flow rates have a better safety profile, reduce IOP and pressure fluctuations while offering equal efficiency, including comparable surgical time. Using central corneal thickness (CCT) as an indicator of corneal trauma, it has been shown that patients that have had surgery with low-flow rates present no change in the CCT postoperatively while patients in the high-flow rates show signs of corneal damage as well as greater anterior segment inflammation. As less fluid turbulence is created with low-flow rates, there is decreased risk of fragment contact with the cornea's inner surface, thus reducing cell loss. Alcon Laboratories, Inc. developed Active Fluidics which allows to stabilize intraocular pressure and prevent IOP fluctuations as well as IOP surges during surgery. It is now further equipped with the Active Sentry handpiece which is integrated to the surgical instrument and acts as a sensor to pressure variation. It allows rapid feedback to maintain a stable anterior chamber. Our research project aims to assess the outcomes following phacoemulsification done with physiological IOP with the help of the Active Sentry handpiece compared to traditional high IOP levels.
PURPOSE: To stably and economically produce a new antitumoral compound capable of manifesting cancer cell proliferation inhibiting actions on human tumoral cells in a trace amount by culturing a cell having an origin in the genus Taxus. CONSTITUTION: A cell having an origin in the genus Taxus (e.g. a new leaf of a tree of Taxus capsidata cultivated in Kawasaki City in Kanagawa Prefecture, Japan) is cultured (under conditions of 20-25 deg.C culture temperature and pH5.8 for 10-100 days in the dark, etc.) and the resultant cultured cell is then recovered to collect a compound of the formula present in a cultured cell thereof. Furthermore, the physicochemical properties of the compound are as follows: appearance: white powder; solubility: sparingly soluble in water and readily soluble in methanol; molecular weight: 854; ultraviolet maximum absorption wavelength: 227nm, etc. Furthermore, e.g. 0-10mg/l auxin compound, 0-10mg/l cytokinins and 0-100mg/l gibberellins are preferably added into the culture medium.
<P>PROBLEM TO BE SOLVED: To accurately specify a mouse BAG5 domain to determine its three-dimensional structure to clarify the relationship between its structure and function.  <P>SOLUTION: A polypeptide comprising a specific amino acid sequence forming the mouse BAG5 domain is provided. A polynucleotide encoding the polypeptide is provided. A method for producing the polypeptide is provided. A method for screening substances interacting with the polypeptide is also provided.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Experimental group performs augmented reality and wearable sensor-based home rehabilitation exercise for 4 weeks. And then, their exercise compliance is monitored by medical staff.
Calcitonins and calcitonin derivatives such as are employed for therapy for, for example, osteoporosis. Paget's disease or hypercalcemia. The calcitonins and calcitonin derivatives are distinguished by a bridging of the amino acids present in the positions 17 and 21. In this case, by means of a suitable choice of the amino acids present in these positions an 18- or 19-membered ring is produced. This ring leads to an increased conformational stability and to an increased activity of the modified calcitonin. A particularly suitable hCt (human Ct) analog is the cyclo17,21-[Asp17, Orn21]-hCt according to the invention having a 19-membered ring structure between the lactam-bridged Asp17 and Orn21.
At present, researches on brain fatigue recognition are still in the stage of single task and simple brain region network features, while researches on high-order brain functional network features and brain region state mechanisms during fatigue in multi-task scenarios are still insufficient, making it difficult to meet the needs of fatigue recognition under complex conditions. Therefore, this study utilized functional near-infrared spectroscopy (fNIRS) technology to explore the correlation and differences in the low-order and high-order brain functional network attributes of three task induced mental fatigue, and to explore the brain regions that have a major impact on mental fatigue. Self-training algorithms were used to identify the three levels of brain fatigue. The results showed that during the fatigue development, the overall connection strength of the endothelial cell metabolic activity and neural activity frequency bands of the low-order brain functional network first decreased and then increased, while the myogenic activity and heart rate activity frequency bands showed the opposite pattern. Network topology analysis indicated that from no fatigue to mild fatigue, the clustering coefficient of endothelial cell metabolic activity and myogenic activity frequency bands significantly decreased, while the characteristic path length of myogenic activity significantly increased; when experiencing severe fatigue, the small-world attribute of the neural frequency band significantly weakened. However, each frequency band maintained its small-world attribute, reflecting the self-optimization and adaptability of the network during the fatigue process. During mild fatigue, neuronal activity bands' node degree, cluster coefficient, and efficiency rose in high-order brain networks, while low-order networks showed no significant changes. As fatigue progressed, the myogenic activity bands of high-order network properties dominated, but neural bands gained prominence in mild fatigue, approaching the level of myogenic bands in severe fatigue, indicating that brain fatigue orchestrated a shift from myogenic to neural dominance in frequency bands. In addition, during the process of fatigue, the four network attributes of the high-order network cluster composed of low-order nodes related to the prefrontal cortex region, left anterior motor region, motor assist region, and left frontal lobe eye movement region significantly increased, indicating that these brain regions had a significant impact on brain fatigue status. The accuracy of using both high-order and low-order features to identify fatigue levels reached 88.095%, indicating that the combined network features of both high-order and low-order fNIRS signals could effectively detect multi-level mental fatigue, providing innovative ideas for fatigue warning.
FIELD: veterinary medicine. SUBSTANCE: method involves administering biologically active preparation before harmful environment factor action takes place. Substances prepared mainly from celandine (Chelidonium majus L. ) are applied as the biologically active preparation. It is administered per os at a dose of 0.3-3.0 ml/kg up to 6 months long and more at least once a week. The preparation is administered per os or intramuscularly at a dose of not greater than 3.0 ml/kg in 30-70 injections long courses during 2-3 months after the exposure to the harmful factor with 3 month or more long pauses until complete rehabilitation occurs. EFFECT: enhanced effectiveness of treatment; increased organism bioresistance. 2 dwg, 2 tbl
The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess musclerelaxing and aggression-inhibiting properties. These new derivatives have the structural formula     AND THEIR ACID ADDITION SALTS, IN WHICH R1 and R2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1-4 carbon atoms; R3 is a substituent selected from the group consisting of -CN, CONH2, -COOCH3, -COOC2H5, -COOH, and -COOMe, where Me is a metallic cation; n is an integer selected from 1 and 2; and m is an integer selected from 1,2, and 3, and wherein the rings A and B may be substituted, ring A being substituted preferably with a halogen such as chlorine or with nitro, trifluoromethyl, methyl, methoxy or methylmercapto, preferably in the 5 position, and ring B being preferably substituted in the 2'' position with chlorine or fluorine. The radicals R1 and R2 preferably signify hydrogen or a methyl group, or a n-butyl group in the case of Ring B. The metal cation Me is preferably a pharmacologically acceptable metal cation, as for example sodium, potassium, calcium or ammonium. Compounds represented by the above structural formula may be produced by reacting a compound represented by the formula WITH A COMPOUND HAVING THE FORMULA Y-CmH2m-R3, one of X and Y signifying the substituent R2-NH- and the other signifying a halogen atom, preferably a bromine or chlorine atom, so as to form the above specified benzophenone derivative with the elimination of H-Hal, R1, R2, R3, n and m being as defined above, and the rings A and B being optionally substituted as discussed above. The hydrogen halide which is eliminated is advantageously bound by the addition of an acid-binding agent, as for example, a molar excess of the amine used in the reaction or, for example, triethylamine, dimethylaniline, potassium or sodium carbonate or sodium bicarbonate. The reaction is carried out in a suitable solvent, preferably at an elevated temperature, typically the reflux temperature of the solvent used.