anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses an oxytropis Ehrig cinerea FEL2-OG which is preserved in China type culture collection center on October 18, 2008, and the preservation code is CCTCC NO: M 208142. Bacterial colony of bacterial strain is in a circular shape, is white in the beginning, and gradually changes to primrose yellow, yellow brown and black brown, and the centre of the bacterial colony slightly protrudes. Mycelium has transverse septa but has no mediastinums. Conidiophores peduncles grow on part of the aging hypha h, and the conidiophores have braches. Conidiophores and the conidiophores peduncles have transverse septa but have no mediastinums, the transverse septa film of the conidiophores is thicker, and the number of the transverse septa is 1 to 3; spores are in long rod shapes and are similar to column shapes, and the size of the conidiophores is 20 to 70 microns*5 to 10 microns. The bacterial strain is obtained from leaves, stems and seeds of oxytropis glacialis through manual separation and filtration, and has the function of synthesizing main toxin, that is swainsonine (Swainsonine, SW) of locoweed.
The study is restricted to patients having had primary systemic chemotherapy for stage II and III breast cancer. Participation in a preoperative chemotherapy trial investigating anthracycline and taxane based regimen is allowed, but not mandatory for all patients. Patients must have significant remaining tumor tissue in the breast and/or axillary lymph node. This implies resistance to further chemotherapy and a clinically relevant risk for relapse. Bisphosphonates have a distinct mechanism of action and have demonstrated efficacy in the treatment of breast cancer with metastasis to the bone as well as adjuvant treatment after surgery of primary breast cancer. The 3rd generation bisphosphonate zoledronic acid has a favorable toxicity profile and can be conveniently given to patients over a long term period.
<P>PROBLEM TO BE SOLVED: To provide a method for constructing, applying, and producing new polypeptides in which binding activity or specificity for a hapten and an antigen is enhanced or improved.  <P>SOLUTION: Target-binding polypeptides have (a) an SCR (stable core polypeptide region), and (b) at least one TBR (target-binding region). The TBR is covalently attached to the SCR and which has optionally been subjected to a maturation step in order to modify the specificity, the affinity or the activity of binding to the target. The polypeptides may self-associate to form stable dimers, aggregates, or arrays. The polypeptides have utility in the diagnostic, therapeutic, predictive, or preventative fields of the pharmaceutical and health care industries, as well as more general applications in the detection and assay of chemical substances.  <P>COPYRIGHT: (C)2009,JPO&INPIT
BACKGROUND: In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially estrogen, suggests that an upstream mechanism or even independent of estrogen plays an important role in regulating asthma pathophysiology. In this context, in our previous studies, we explored kisspeptin (Kp) and its receptor Kiss1R's signaling in regulating human airway smooth muscle cell remodeling in vitro and airway hyperresponsiveness (AHR) in vivo in a mouse (wild-type, WT) model of asthma. In this study, we evaluated the effect of endogenous Kp in regulating AHR and remodeling using Kiss1R knockout (Kiss1R-/-) mice.
METHODS: C57BL/6J WT (Kiss1R+/+) and Kiss1R-/- mice, both male and female, were intranasally challenged with mixed-allergen (MA) and/or phosphate-buffered saline (PBS). We used flexiVent analysis to assess airway resistance (Rrs), elastance (Ers), and compliance (Crs). Following this, broncho-alveolar lavage (BAL) was performed for differential leukocyte count (DLC) and cytokine analysis. Histology staining was performed using hematoxylin and eosin (H&E) for morphological analysis and Masson's Trichrome (MT) for collagen deposition. Additionally, lung sections were processed for immunofluorescence (IF) of Ki-67, α-smooth muscle actin (α-SMA), and tenascin-c.
RESULTS: Interestingly, the loss of Kiss1R exacerbated lung function and airway contractility in mice challenged with MA, with more profound effects in Kiss1R-/- female mice. MA-challenged Kiss1R-/- mice showed a significant increase in immune cell infiltration and proinflammatory cytokine levels. Importantly, the loss of Kiss1R aggravated Th2/Th17 biased cytokines in MA-challenged mice. Furthermore, histology of lung sections from Kiss1R-/- mice showed increased collagen deposition on airway walls and mucin production in airway cells compared to Kiss1R+/+ mice. In addition, immunofluorescence analysis showed loss of Kiss1R significantly aggravated airway remodeling and subsequently AHR.
CONCLUSIONS: These findings demonstrate the importance of inherent Kiss1R signaling in regulating airway inflammation, AHR, and remodeling in the pathophysiology of asthma.
OBJECTIVE: This retrospective observational study aims to evaluate the association between the extent of parametrial invasion (PMI) and disease-free survival (DFS) and cancer-specific survival (CSS) in patients with locally advanced cervical cancer (LACC).
MATERIALS AND METHODS: This study included patients with LACC showing parametrial invasion at Magnetic Resonance Imaging (MRI). They were treated with neoadjuvant chemo-radiotherapy (CT/RT) before undergoing radical hysterectomy. The staging MRIs were reviewed retrospectively. Measurements of maximum PMI (PMImax) and parametrial length were taken bilaterally. After that, PMIratio was calculated by dividing PMImax by parametrial length. Analysis was conducted on homogeneous subsets of patients, grouped based on their pathological lymph nodal evaluation (N- and N+). Correlations between PMImax and PMIratio with DFS and CSS were evaluated in both the N- and N+ groups, employing univariable Cox regression analysis.
RESULTS: Out of 221 patients, 126 (57%) had non-metastatic lymph nodes (N-), while 95 (43%) had metastatic lymph nodes (N+). The median observation period for all these patients was 73 months (95% confidence interval [CI]: 66-77). The 5-year DFS and CSS probability rates were 75% and 85.7%, respectively, for the N- group and 54.3% and 73.6%, respectively, for the N+ group. A higher PMImax (hazard ratio [HR] = 1.09) and PMIratio (HR = 1.04) correlated with worse overall survival in patients in the N- group (p = 0.025 and p = 0.042). These parameters did not show a significant statistical association in the N+ group.
CONCLUSIONS: The degree of PMI evaluated on MRI affects outcome in N- patients with LACC.
CLINICAL RELEVANCE STATEMENT: The degree of MRI parametrial invasion affects disease-free survival and cancer-specific survival in patients with the International Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical cancer. This MRI finding can be easily incorporated into routine clinical practice.
KEY POINTS: • Visual assessment of parametrial invasion on MRI was not significantly associated with prognosis in locally advanced cervical cancer (LACC). • A greater degree of parametrial invasion is associated with poorer disease-free survival and cancer-specific survival in patients with LACC without metastatic lymph node involvement. • The degree of parametrial invasion at MRI has no correlation with prognosis in LACC with metastatic lymph nodes.
The participants randomized to Baduanjin exercise will collectively practice at cardiac rehabilitation centre in Guangdong Provincial Hospital of Chinese Medicine. A detailed description of a standardized Baduanjin exercise protocol complied with the "Health Qigong Baduanjin Standard" enacted by the General Administration of Sports in 2003. Each Baduanjin exercise session lasts 45 minutes and continues twice per week for 12 weeks.
The original version of WUSPI was translated into Turkish via multistep translation rules. It is culturally adapted into Turkish. The semantic equivalence of the new scale was evaluated and the Turkish version of the WUSPI (WUSPI-Tr) has been created. It is applied to 100 wheelchair users to investigate the validity of the scale. People who are at least for 1 year using a manual wheelchair as their primary means of mobility, cognitively unimpaired, literate, and older than 18 years are included in this study. The reliability of the scale was assessed by internal consistency and test-retest analysis. As a result of the analysis, the Cronbach Alfa value was calculated as 0.894, and WUSPI-Tr was found to have high internal consistency. The WUSPI-Tr questionnaire was re-administered to 50 participants for 7 to 14 days for the test-retest method and the results were compared with the Interclass Correlation Coefficient (ICC) method. WUSPI has been found to have high reliability (0.997). Validation of WUSPI-Tr was assessed by the concurrent validity method. To establish concurrent validity, WUSPI scores were compared to SPADI and ASES scores by Spearman correlation analysis. The correlation coefficient of WUSPI-Tr with SPADI is 0.931 and with ASES was -0.812. These results show that there was a positively excellent correlation with SPADI and, negatively excellent correlation with ASES (p \< 0,001). As a result, the Turkish version of WUSPI-Tr is a valid and reliable tool.
The present invention discloses Chinese preparatory medicine for curing burns and scalds and the preparation method of the Chinese preparatory medicine. Mountain natural wild fungi are used as raw material, and paste is added to the raw material. Then, the mixture is fried to form the Chinese preparatory medicine. The Chinese preparatory medicine has a technical scheme that the Chinese preparatory medicine has components of natural edible wild fungi: ground agaric, brush handle fungi, wood cage fungi and horse leather fungi. The Chinese preparatory medicine is characterized in that when the burns and the scalds are cured, no scar remains on affected parts, and appearance is not influenced. After high degree burns of the second grade and the third grade are cured, rib contraction can not occur. The color of grown skins is similar to the original skin color. The Chinese preparatory medicine has the advantages of muscle regeneration, suppuration, rapid pain alleviation, rapid clearance of accumulated water and no sequela.
PURPOSE: Babble Boot Camp (BBC) is a parent-implemented telepractice intervention for infants at risk for speech and language disorders. BBC uses a teach-model-coach-review approach, delivered through weekly 15-min virtual meetings with a speech-language pathologist. We discuss accommodations needed for successful virtual follow-up test administration and preliminary assessment outcomes for children with classic galactosemia (CG) and controls at age 2.5 years.
METHOD: This clinical trial included 54 participants, 16 children with CG receiving BBC speech-language intervention from infancy, age 2 years, five children receiving sensorimotor intervention from infancy and changing to speech-language intervention at 15 months until 2 years of age, seven controls with CG, and 26 typically developing controls. The participants' language and articulation were assessed via telehealth at age 2.5 years.
RESULTS: The Preschool Language Scale-Fifth Edition (PLS-5) was successfully administered with specific parent instruction and manipulatives assembled from the child's home. The GFTA-3 was successfully administered to all but three children who did not complete this assessment due to limited expressive vocabularies. Referrals for continued speech therapy based on PLS-5 and GFTA-3 scores were made for 16% of children who received BBC intervention from infancy as compared to 40% and 57% of children who began BBC at 15 months of age or did not receive BBC intervention, respectively.
CONCLUSIONS: With extended time and accommodations from the standardized administration guidelines, virtual assessment of speech and language was possible. However, given the inherent challenges of testing very young children virtually, in-person assessment is recommended, when possible, for outcome measurements.
Postoperative adhesion (PA) is a severe complication of abdominal surgery caused by the inability of clinical physical barriers to cope with diverse pathological factors in the process of PA formation. Herein, we described a multifunctional hydrogel composed of bioactive nanoparticles (BNs) and dual-responsive hydrogel to serve as a combination of physical and pharmacological therapy for preventing PA. Specifically, BNs with pro-inflammatory cell-targeted aggregation were designed by integrating hyaluronic acid onto the polydopamine (PDA)-coated hollow ZrO2 nanoparticles loaded with antimicrobial peptides and platelet lysates that can eliminate bacterial infection and promote tissue repair. PDA can remove the excessive reactive oxygen species (ROS) and thus suppress the oxidative stress damage and accompanying inflammation in the presence of high ROS. The dynamically cross-linked host hydrogel presents injectable yet microenvironment-responsive properties, which enables complete coverage of the uneven tissue and instantly forms a physical barrier to effectively isolate injured tissues and neighboring organs, and synchronously acts as a niche to deliver the BNs in a controlled way. The hydrogel demonstrates a remarkable antiadhesion effect in a rat cecum-abdominal wall adhesion model. Together, this "all-in-one" composite hydrogel strategy capable of a physical barrier capability and pharmacological effects represents a promising clinical solution to prevent PA.
PURPOSE:To easily regulate hydrophile-lipophile balance and to obtain a hydrophilic gelatinous compsn. and an oil-in-water type emulsified compsn. having high safety and stability by blending lysophospholipid and cholesterol with a water phase component and an oil phase component and using the resulting emulsifier. CONSTITUTION:One or more kinds of lysophospholipids or hydrogenated lysophospholipids and cholesterol or one or more kinds of cholesterol fatty acid esters are blended with an oil phase component such as liq. paraffin or squalane and a water phase component such as water or ethanol. When the resulting emulsifier is used, hydrophile-lipophile balance can easily be regulated and a hydrophilic gelatinous compsn. and an oil-in-water type emulsified compsn. having high safety and stability are obtd.
OBJECTIVE: Our objective was to explore the patterns of resting-state network (RSN) connectivity alterations and investigate how the influences of individual-level network connections on cognition varied across clinical stages without assuming a constant relationship.
METHODS: 108 PD patients with continuum of cognitive decline (PD-NC = 46, PD-MCI = 43, PDD = 19) and 34 healthy controls (HCs) underwent resting-state functional MRI and neuropsychological tests. Independent component analysis (ICA) and graph theory analyses (GTA) were employed to explore RSN connection changes. Additionally, stage-dependent differential impact of network communication on cognitive performance were examined using sparse varying coefficient modeling.
RESULTS: Compared to HCs, the dorsal attention network (DAN) and dorsal sensorimotor network (dSMN) were central networks with decreased connections in PD-NC and PD-MCI stage, while the lateral visual network (LVN) emerged as a central network in patients with dementia. Additionally, connectivity of the cerebellum network (CBN) increased in the PD-NC and PD-MCI stages. GTA demonstrated decreased nodal metrics for DAN and dSMN, coupled with an increase for CBN. Moreover, the degree centrality (DC) values of DAN and dSMN exhibited a stage-dependent differential impact on cognitive performance across the continuum of cognitive decline.
CONCLUSION: Our findings suggest that across the progression of cognitive impairment, the LVN gradually transitions into a core node with reduced connectivity, while the enhancement of connections in CBN diminishes. Furthermore, the non-linear relationship between the DC values of RSNs and cognitive decline indicates the potential for tailored interventions targeting specific stages.
Teratogenic Effects: Pregnancy Category B. Reproduction studies with cromolyn sodium administered subcutaneously to pregnant mice and rats at maximum daily doses of 540 mg/kg (1620 mg/m2) and 164 mg/kg (984 mg/m2), respectively, and intravenously to rabbits at a maximum daily dose of 485 mg/kg (5820 mg/m2) produced no evidence of fetal malformation. These doses represent approximately 57, 35, and 205 times the maximum daily human dose, respectively, on a mg/m2 basis. Adverse fetal effects (increased resorption and decreased fetal weight) were noted only at the very high parenteral doses that produced maternal toxicity. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. 

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Cromolyn Sodium Ophthalmic Solution is administered to a nursing woman. 

Pediatric Use: Safety and effectiveness in children below the age of 4 years have not been established.
PROBLEM TO BE SOLVED: To obtain a composition for a percutaneous delivery system having excellent skin-penetration effect and exhibiting high analgesic and antiinflammatory effect by dispersing a nonsteroidal antiinflammatory agent in a specific polymer base. SOLUTION: A nonsteroidal antiinflammatory agent such as a propionic acid derivative is dispersed in a non-polar tacky polymer base. The polymer base is preferably free from functional group such as natural rubber, butyl rubber, polyisobutylene and polystyrene. The total amount of the nonsteroidal antiinflammatory agent is 0.5-30wt.% based on the total weight of the composition excluding the releasing paper and the backing layer. The propionic acid derivative is preferably ketoprofen, flurbiprofen, loxoprofen and pranoprofen, especially ketoprofen. The composition may be further incorporated with one or more compounds selected from a dissolution assistant, an absorbefacient, a plasticizer, a tackifier and an antioxidant.
PURPOSE: A composition containing Lophatherum gracile Brongn extract for preventing or treating inflammatory diseases or vascular diseases is provided to suppress NO generation and induce blood vessel relaxation. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory diseases contains Lophatherum gracile Brongn extract as an active ingredient. A pharmaceutical composition for preventing and treating vascular diseases contains the Lophatherum gracile Brongn extract as an active ingredient. The Lophatherum gracile Brongn extract is isolated using water, low alcohol of 1-4 carbon atoms or mixture thereof. The content of Lophatherum gracile Brongn extract is 0.0001-30 weight%. The pharmaceutical composition additionally contains pharmaceutically acceptable carrier. A health food for preventing or treating inflammatory diseases or vascular diseases contains the Lophatherum gracile Brongn extract.
INTRODUCTION: "Programme science" deploys scientific methods to address questions that are a priority to support the impact of public health programmes. As such, programme science responds to the challenges of making such studies: (1) feasible to undertake, (2) useful, (3) rigorous, (4) real-world-relevant, (5) informative, and undertaken by (6) equitable partnerships. The acronym "FURRIE" is proposed to describe this set of six challenges. This paper discusses selected HIV/STI (sexually transmitted infection) programme science case studies to illustrate how programme science rises to the FURRIE challenges.
DISCUSSION: One way in which programme science is made more feasible is through the analysis and interpretation of data collected through service delivery. For some questions, these data can be augmented through methods that reach potential clients of services who have not accessed services or been lost to follow-up. Process evaluation can enhance the usefulness of programme science by studying implementation processes, programme-client interactions and contextual factors. Ensuring rigour by limiting bias and confounding in the real-world context of programme science studies requires methodological innovation. Striving for scientific rigour can also have the unintended consequence of creating a gap between what happens in a study, and what happens in the "real-world." Community-led monitoring is one approach to grounding data collection in the real-world experience of clients. Evaluating complex, context-specific strategies to strengthen health outcomes in a way that is informative for other settings requires clear specification of the intervention packages that are planned and delivered in practice. Programme science provides a model for equitable partnership through co-leadership between programmes, researchers and the communities they serve.
CONCLUSIONS: Programme science addresses the FURRIE challenges, thereby improving programme impact and ultimately health outcomes and health equity. The adoption and adaptation of the types of novel programme science approaches showcased here should be promoted within and beyond the HIV/STI field.
BACKGROUND: Obesity is a complex chronic disease associated with several adverse health outcomes that increase mortality risk. Physical activity (PA) is recommended for the prevention and treatment of obesity and is related to a decreased risk of cardiovascular disease, cancer and all-cause mortality. This systematic review and meta-analysis estimates the effect of PA levels on mortality (cardiovascular, cancer and all-cause mortality) in adults with obesity.
METHODS: A systematic search was conducted in MEDLINE, Embase, Web of Science and SPORTDiscus from inception to June 2024. Prospective cohort studies that explored the association between PA and mortality in adults with obesity (according to their body mass index, ≥ 30 kg/m2) aged ≥ 18 years were included. Our main outcomes were all-cause mortality, and cardiovascular, and cancer mortality reported in primary studies by hazard ratios or relative risk, which were pooled for the meta-analysis when at least two studies reported the effect estimate for the same outcome. The PRISMA recommendations and the MOOSE guidelines were followed. The reported mortality risk estimates comparing insufficiently active versus active (moderate to very active) adults with obesity were pooled using the DerSimonian and Laird random-effects model.
RESULTS: A total of 9 prospective cohort studies involving 199,425 adults with obesity (age range: 35-85 years) were included, of which 59,873 were insufficiently active and 84,328 were active. Active individuals had a 21% lower risk of all-cause mortality (HR: 0.79, 95%CI: 0.74 to 0.84; I2 = 38.2%), and a 24% lower risk of cardiovascular mortality (HR: 0.76, 95%CI: 0.66 to 0.87; I2 = 0.0%) than insufficiently active individuals. The HR for cancer mortality was 0.91 (95%CI: 0.80 to 1.02; I2 = 0.0%), and although this was mostly consistent with a benefit, it was based on only two studies.
CONCLUSION: Our data support that moderate to high levels of PA are associated with a 21% lower risk of all-cause and 24% cardiovascular disease mortality in adults with obesity. Although data from the only two published studies seem to indicate a protective effect of PA on cancer risk, the estimates are not statistically significant.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022309346.