anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Although deficits in empathy and social interaction are relatively common in certain forms of FTD and stroke, there are currently no proven treatments for these symptoms. Spouses and caregivers often cite these symptoms as a major concern, and these deficits can have a negative impact on the quality of life that patients experience. The purpose of this study is to evaluate whether or not web-based social training exercises can improve social-cognitive impairments in patients with FTD or right hemisphere stroke. These training exercises have been shown to improve social skills and empathy in other disorders. This study will be the first to examine if these exercises can be effective and feasible for treating social deficits in stroke and FTD.

The study will be based out of the Johns Hopkins Hospital where patients will be assessed three times in total. Patients will be assessed upon enrollment in the study and after each of the two treatment conditions. The training itself will be completed at home on a provided laptop, with monitoring and support by the study team. This study uses a crossover design, which means that all patients will receive the training treatment and a control treatment during their participation in the study. The approximate timeline for the study is 9 weeks total.
Schistosomiasis is classified as among the world's neglected tropical diseases (NTD). Morbidity to S. mansoni is greatest among school-age children who typically have the highest burden of infection. In 2001, World Health Organization (WHO) passed a resolution for large-scale mass drug administration (MDA) using chemotherapy to deworm vulnerable children through school-based programs. However, chemotherapeutic drugs are not recommended for children under the age of 6 years due to their toxicity, despite the fact that this is the age group most infected with schistosomiasis. Additionally, the current school-based MDA does not consider child malnutrition a very common malady in African countries. The current invention discloses the making of a food composition comprising common edible cereals like maize, sorghum or a combination, fortified with extracts from Carica papaya (C. papaya) fruit seeds to form a mixture, and the use of this mixture in the management and or treatment of schistosomiasis.
A comparative study to determine the effects of butyeko breathing techniques and Active Cycle of Breathing technique on dyspnea and quality of life in patients with chronic obstructive pulmonary disease. As few researches on Butyeko breathing techniques are still present on COPD most of them are on asthma. The goal of the Butyeko Method is to improve breathing patterns, as indicated by achieving a higher breath hold time (control pause). Every five seconds improvement to the control pause, results in an alleviation of breathing difficulty and improved control of COPD The Butyeko method is a purported method of "retraining" the body's breathing pattern to correct for the presumed chronic hyperventilation and hypocapnea, and thereby treat or cure the body of these medical problems. Patients with chronic obstructive pulmonary disease (COPD) often suffer from expectoration. To address this problem, active cycle of breathing techniques (ACBT) can be applied in patients of COPD. In our study daily Butyeko breathing exercise and active cycle of breathing technique session of 30 to 35 minutes will be given to patients and effects of both techniques will be compared.

A randomized clinical trial will be conducted using convenient sampling or randomized sampling technique in population of chronic obstructive pulmonary disease (COPD).Total sample size will be of 40 and two Groups will be made Group A 20 participants received Buyteko breathing technique and Groups B 20 participants received Active cycle of breathing technique. Data will be collected by using Borg's dyspnea scale, St.George Respiratory questionnaire and by pulmonary function testing. Data will be collected from pulmonary ward Jinnah hospital Lahore whole study will take total duration of 10 months and data will be analyzed using latest version of SPSS-25 software.
Disclosure herein is related to a telemedicine information system. The telemedicine information system includes a monitoring end which receives the physiological signals generated by one or more physiological sensors disposed at the client end over a network. The medical staff uses monitoring terminal device at the monitoring end. The monitoring terminal device is connected with a monitoring server for acquiring the physiological signals since the server periodically retrieves and records the signals generated by the client end's sensors. The signals will be converted to the meaningful information allowing the medical staff to monitor the remote client's physiological condition. The claimed system achieves an efficient remote medical process since the person at the monitoring end may anytime acknowledge the client's condition.
The primary objective of this Phase 3 study is to evaluate the impact of NAC 1200 mg versus matched placebo (PBO) twice daily, added to contingency management (CM), on cannabis use among treatment-seeking cannabis-dependent adults (ages 18-50). After assessment and inclusion into the study, participants will be randomized to receive a 12-week course of NAC 1200 mg or matched placebo twice daily. All participants will concurrently participate in a twice-weekly contingency management (CM) intervention. Medication management will be conducted weekly throughout treatment by the medical clinician. Urine cannabinoid testing will occur at all visits, and will be used as the primary determinant of cannabis use. Participants will return approximately four weeks after treatment conclusion for evaluation of adverse events with medication discontinuation and sustained treatment effects.
The CIME model integrates interventions for malaria, dengue, tuberculosis, childhood diarrhoea and Rapid Diagnostic Test (RDT)-negative fever. It will involve the recruitment and training of a volunteer to implement the CIME model in each village.

The primary outcome of the trial is blood examination rate as determined by number of RDTs for malaria performed per week per village. 140 villages in 8 townships across Ayeyarwaddy, Bago and Yangon Regions and Kayah State in Myanmar will be sampled at random with probability proportional to size. Study populations include villages with ICMVs who will be re-trained as CIME volunteers (intervention phase) and the community members in the service catchment areas of those volunteers. An open stepped-wedge cluster-randomised controlled trial, randomized at the volunteer level (i.e. the volunteer and the village / workplaces they service), will be conducted over 6-months to evaluate the effectiveness and cost-effectiveness of the CIME model intervention. The stepped-wedge design will comprises 24 weekly measurements of the number of malaria blood examinations performed by each village, with villages grouped into 10 blocks of 14 villages and transitioned from control to intervention phases at bi-weekly intervals following a universal two-week control period. Differences in the per weekly rate of blood examination (primary outcome), will be estimated across intervention and control phases using a generalised linear (e.g. Poisson or negative-binomial link functions) mixed modelling analytical approach with maximum likelihood estimation.
Extreme heat caused by climate change is increasing the transmission of infectious diseases, resulting in a sharp rise in heat-related illness and mortality. Understanding the mechanistic link between heat, inflammation, and disease is thus important for public health. Thermal hyperpnea, and consequent respiratory alkalosis, is crucial in febrile seizures and convulsions induced by heat stress in humans. Here, we address what causes thermal hyperpnea in neonates and how it is affected by inflammation. Transient receptor potential cation channel subfamily V member 1 (TRPV1), a heat-activated channel, is sensitized by inflammation and modulates breathing and thus may play a key role. To investigate whether inflammatory sensitization of TRPV1 modifies neonatal ventilatory responses to heat stress, leading to respiratory alkalosis and an increased susceptibility to hyperthermic seizures, we treated neonatal rats with bacterial LPS, and breathing, arterial pH, in vitro vagus nerve activity, and seizure susceptibility were assessed during heat stress in the presence or absence of a TRPV1 antagonist (AMG-9810) or shRNA-mediated TRPV1 suppression. LPS-induced inflammatory preconditioning lowered the threshold temperature and latency of hyperthermic seizures. This was accompanied by increased tidal volume, minute ventilation, expired CO2, and arterial pH (alkalosis). LPS exposure also elevated vagal spiking and intracellular calcium concentrations in response to hyperthermia. TRPV1 inhibition with AMG-9810 or shRNA reduced the LPS-induced susceptibility to hyperthermic seizures and altered the breathing pattern to fast shallow breaths (tachypnea), making each breath less efficient and restoring arterial pH. These results indicate that inflammation exacerbates thermal hyperpnea-induced respiratory alkalosis associated with increased susceptibility to hyperthermic seizures, primarily mediated by TRPV1 localized to vagus neurons.
Processing of residual urine for proteomic, metabolomic and transcriptomic analysis, immunocytochemical or fluorescence in-situ hybridisation (FISH) analysis, flow cytometry analysis (FACS), immunophenotyping. If positive for target bacteria: sample stored at biobank. If previous antibiotic treatment: plasma sample storage. Exploration of bacterial properties (Highly sensitive mass spectrometry, whole genome sequencing), expression of virulence factors, genomic alterations of bacterial species, metabolism, surface molecule expression, gene expression levels, cytokine levels, immune cell biology, antibiotic concentration (chromatography/mass spectrometry). Demographical, clinical, microbiological, laboratory, epidemiological and hospital-associated data will be analysed. 500 samples per target bacteria (S. aureus, P. aeruginosa, E. coli, Klebsiella species) included. First, a pilot study from randomly selected patients within each bacterial species group (n=50, each) is done.
In a process for producing N-acylaminomercaptans, ethylene-imine is reacted with thioacetic acid or thiobenzoic acid.  An indifferent solvent may be added and it is often advantageous to exclude oxygen. The reaction products may be converted by known methods into S-acyl derivatives which may be reconverted to the free thiols by saponification.  The products may be employed as intermediates for medicaments, cosmetic agents and textile assistants.  Proteinaceous fibrous materials such as hair, wool, leather or sinews are deformed by treatment with the products.  The thiol compounds are employed as aqueous, preferably weakly alkaline solutions to impregnate the fibrous materials which on drying retain the form acquired during the treatment (see Group IV (c)).  In examples: ethyleneimine is added to thioacetic acid in methanol and the mixture boiled under reflux, the solvent is removed and the product is distilled in vacuo and is converted to the S-acetyl derivative by leading in ketene (1); and thiobenzoic acid is boiled under reflux with ethylene-imine in ether (2).ALSO:Proteinaceous fibrous substances e.g. hair, sinews and wool, are deformed by treatment with aqueous solutions of N-acylaminomercaptans obtained by reacting ethylene imine with thioacetic acid or thiobenzoic acid (see Group IV(b)).  0.1 to 10 per cent aqueous solutions are employed to impregnate the fibrous materials and after drying the material retains the form into which it has been brought or which it has acquired during the treatment. Hair may be uncurled or waved and permanent ironed pleats may be produced in woollen materials.  After-treatments with weak oxydizing agents such as hydrogen peroxide may be applied to the materials.  In examples: A tress of natural hair is impregnated with an aqueous, weakly ammoniacal solution of the thiol compound obtained by reacting thioacetic acid and ethylene-imine and is crimped by passing through a profiled roller and drying (1); and woollen material is laid in pleats, moistened with an aqueous solution of the same product and ironed, when stable pleats are obtained.
PURPOSE: A method for preparing Ulmus davidiana var. japonica root extract is provided to obtain antidiabetic extract of high yield. CONSTITUTION: A composition for suppressing diabetes contains Ulmus davidiana var. japonica root extract as an active ingredient, prepared using ethanol solution. The composition is a food composition. A method for preparing the extract comprises a step of adding 40-60%(v/v) ethanol to Ulmus davidiana var. japonica root at pH 4-7 and a step of sonicating.
In the control arm, patients will have oxygen titrated per current standard of care (SpO2=88-92%, titrate FiO2 at least every 4 hours). Physician place oxygen titration orders in EMR and respiratory therapists conduct FiO2 titration without electronic alerts.
Myelosuppression: DROXIA may cause severe myelosuppression. Do not give if bone marrow function is markedly depressed. Monitor blood counts at baseline and throughout treatment. Interrupt treatment and reduce dose as necessary [see Warnings and Precautions (5.1)].

Malignancies: DROXIA is carcinogenic. Advise sun protection and monitor patients for malignancies [see Warnings and Precautions (5.3)].
OBJECTIVE: To analyze the role of endoscopic ultrasonography (EUS) in predicting the risk of cicatricial stenosis after chemical esophageal burn.
MATERIAL AND METHODS: A retrospective study included 56 patients with chemical esophageal burn grade III/IV. Primary endoscopy was performed upon admission. To estimate lesion of muscular layer of esophageal wall, we performed EUS using mini-sensor 20 MHz in 3-5 days after injury. To assess severity of chemical esophageal burn, we used the classification proposed by Volkov S.V. (1997) and supplemented by Pesnya-Prasolova E.A. (2006): grade I - catarrhal damage, grade II - erosive, grade III - ulcerative, grade IV - ulcerative-necrotic damage.
RESULTS: To predict the risk of cicatricial esophageal stenosis, we identified 4 grades (a, b, c, d) of damage to muscular layer of esophageal wall considering EUS data. There was no esophageal stenosis in chemical esophageal burn grade III/IVa and acetic essence poisoning with esophageal burn grade IVb. Cicatricial stenosis occurred in 22 (78.6%) out of 28 patients with chemical esophageal burn grade IV (chemical burn grade IVb following alkalis poisoning and in all patients with chemical burn grade IVc/IVd). The risk of cicatricial stenosis was 9.4 times higher after alkalis burn compared to acetic acid burn.
CONCLUSION: EUS in chemical esophageal burn grade IV made it possible to identify additional grades (a, b, c, d) of damage to muscular layer of esophageal wall. This increased the effectiveness of endoscopic diagnostics and assessment of the risk of cicatricial esophageal stenosis.
Athletic populations have been particularly susceptible to sleep inadequacies, experience several sleep issues, and fall below the age-specific sleep recommendations. However, it is well demonstrated that exercise does not impair sleep by itself, and furthermore, acute post-exercise nutrition could elevate the exercise-induced sleep-optimizing effect, with further benefits for the next physical performance. In line with these findings, in a metanalysis of clinical trials, it was shown that pre-bed carbohydrate availability resulted in significant alterations in sleep architecture. It is of utmost importance to highlight that throughout this metanalysis, it was revealed that no long-term nutrition intervention for sleep optimization has been studied yet. These data raise the question of whether a long-term carbohydrate periodization protocol could optimize sleep and alter gut function in a way that athletic performance will be also enhanced. This would allow elucidating further potential interrelations and biological pathways underlying these adaptations.
### Pregnancy Category C

Animal reproductive studies have not been conducted with quinidine. There are no adequate and well-controlled studies in pregnant women. Quinidine should be given to a pregnant woman only if clearly needed.

Human placental transport of quinidine has not been systematically studied. In one neonate whose mother had received quinidine throughout her pregnancy, the serum level of quinidine was equal to that of the mother, with no apparent ill effect. The level of quinidine in amniotic fluid was about three times higher than that found in serum. In another case, the levels of quinidine and 3-hydroxyquinidine in cord blood were about 30% of simultaneous maternal levels.
Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
The invention relates to the field of health products, and discloses a medicament. The medicament comprises main components of natural precious herbs such as morinda officinalis, herba cistanche, gastrodia elata, eucommia ulmoides, polygonum multiflorum, saffron crocus, medlar, angelica sinensis, rhizoma polygonati, pseudo-ginseng, lucid ganoderma, ginseng and the like. The invention also discloses the content of each component. The medicament comprises a plurality of effective ingredients of panaxoside, panaxadiol saponin and the like, has the functions of improving blood microcirculation, relieving and balancing cranial nerve, smoothing lymph to expel toxin, and promoting metabolism, contains starch, protein, fat, tannin, flavonoids compounds, phenolic compound and trace volatile oil, and also contains microelements iron, zinc and the like with biological activity; the leaf and stem contain a little of alkaloid, which has the functions of whitening the skin, resisting fatigue and caducity, improving mental sleep, physical power and function, and the like. The invention also discloses a preparation method of the medicament disclosed by the invention. The method comprises the steps of selecting materials, cleaning, fertilizing, drying and mechanically crushing. The process is advanced and unique; the dosage form can be changed; any other chemical reagent is not added; the medicament is environment-friendly.
The proposed study is a pilot prospective controlled trial to measure the placental residual blood volume after varying cord clamping protocols when the infants are placed skin-to-skin on the maternal abdomen. The study assessed compliance of the providers with the different protocols. Placental transfusion (PT) has been shown to increase infant body iron stores at 6 months of age without increasing adverse outcomes. However, the optimal protocol to achieve adequate placental transfusion is not known. The practice of cord clamping at birth is not uniform among obstetrical providers because adequate evidence to support early or late cord clamping has been lacking.

Women were eligible to enroll in the study if they had no pregnancy complications, did not smoke, planned to breastfeed, and planned to deliver vaginally between 37 and 416/7 weeks. Women were enrolled prenatally on the labor and delivery unit. At birth, women were assigned to one of four cord clamping/milking groups. A cohort of infants with immediate cord clamping serves as reference group. Infants had blood samples drawn with the routine newborn screening blood samples done at 36 to 48 hours. Information on infant health and feeding was completed through an in-hospital visit to the mother and by home visit at two weeks of age. The primary outcome measures were placental residual blood volume and compliance with the various assigned cord clamping protocols. It was expected that infants with delayed cord clamping or cord milking would have less placental residual blood volume and that most providers would comply with the various random assignments.
In a biometrics system for a building entrance unlocking or a bank account authentication, reference information registered under administration by the system is transmitted to a room or mobile-phone for private storage, with the original reference information deleted from the system. Biologic information gotten upon authentication is transmitted through wireless system to the room or mobile-phone for comparison with the reference, the result being returned to the system. Or, the reference is tentatively sent back to the system for comparison with the gotten biologic information. The biologic information sent to mobile-phone also includes health control information for storage and display. Mobile-phone also can receive blood pressure information at a waiting lounge of medical institution though wireless local communication even if the main power shut down. The communication between the biometrics system and the mobile-phone is encrypted. The system includes sensor unit and protection unit, the abnormality thereof being separately checked.
A method of formulating a medical order for a patient includes transmitting a medical order interface to a healthcare provider interface device. The medical order interface includes a plurality of selectable medical order items. The method further includes, in response to receiving a selection of a medical order item of the plurality of selectable medical order items, transmitting an authorization request interface to the healthcare provider interface device. The authorization request interface includes a set of selectable findings controls. Each selectable findings control of the set of selectable findings controls is associated with a set of medical findings associated with the patient. The authorization request interface includes a send control. In addition, the method includes, in response to receiving a selection of a select findings control and receiving selection of the send control, sending an electronic authorization request. The electronic authorization request includes the set of medical finding associated with the select findings control and order data associated with the medical order item.