anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIMS: In the current guidelines, smartphone photoplethysmography (PPG) is not recommended for diagnosis of atrial fibrillation (AF), without a confirmatory electrocardiogram (ECG) recording. Previous validation studies have been performed under supervision in healthcare settings, with limited generalizability of the results. We aim to investigate the diagnostic performance of a smartphone-PPG method in a real-world setting, with ambulatory unsupervised smartphone-PPG recordings, compared with simultaneous ECG recordings and including patients with atrial flutter (AFL).
METHODS AND RESULTS: Unselected patients undergoing direct current cardioversion for treatment of AF or AFL were asked to perform 1-min heart rhythm recordings post-treatment, at least twice daily for 30 days at home, using an iPhone 7 smartphone running the CORAI Heart Monitor PPG application simultaneously with a single-lead ECG recording (KardiaMobile). Photoplethysmography and ECG recordings were read independently by two experienced readers. In total, 280 patients recorded 18 005 simultaneous PPG and ECG recordings. Sufficient quality for diagnosis was seen in 96.9% (PPG) vs. 95.1% (ECG) of the recordings (P < 0.001). Manual reading of the PPG recordings, compared with manually interpreted ECG recordings, had a sensitivity, specificity, and overall accuracy of 97.7%, 99.4%, and 98.9% with AFL recordings included and 99.0%, 99.7%, and 99.5%, respectively, with AFL recordings excluded.
CONCLUSION: A novel smartphone-PPG method can be used by patients unsupervised at home to achieve accurate heart rhythm diagnostics of AF and AFL with very high sensitivity and specificity. This smartphone-PPG device can be used as an independent heart rhythm diagnostic device following cardioversion, without the requirement of confirmation with ECG.
The invention relates to a method and a signal processing unit (5) for determining the respiratory activity of a patient (P) who is being artificially ventilated using a mechanical ventilator (1). The signal processing unit carries out a first ventilation process during which a ventilation parameter is set to a first setting value. The first signal processing unit generates a first set of signal values depending on values measured at the first setting value. The unit derives a first respiratory activity value and uses for this a predefined pulmonary-mechanics model (20) and the first set of signal values. The unit calculates a measure for the reliability with which the first respiratory activity value matches the corresponding actual respiratory activity measure. The signal processing unit checks, depending on this reliability measure, whether a predefined trigger criterion is met. If said trigger criterion is met, the signal processing unit triggers a change process (a manoeuvre) during which the mechanical ventilator parameter is set to a second setting value. It carries out a further ventilation process, during which the mechanical ventilator parameter is set to the second setting value.
Inflammatory bowel disease (IBD) is a chronic relapsing disease, including ulcerative colitis (UC) and Crohn's disease (CD). Although the etiology of IBD is unknown, but more and more evidence show that the inappropriate immune response to intestinal commensal bacteria leading to dysbiosis, and pathogens further act to the mucosal lymphoid tissue, causing IBD. Has yet not to determine the specific one or more pathogens as the cause of IBD,but literatures confirm the changes of diversity of the intestine flora.Based on the current awareness of changes in the intestinal flora in IBD, fecal microbiota transplantation (FMT) proposed in recent years to rebuild the intestine flora balance to achieve therapeutic purposes. But fecal bacteria of patients can not consistent with donor's for a long term after transplantation and therefore it is not an ideal way for disease control. Maintaining the diversity of flora in a long time so that well controlled the disease become the breakthrough of fecal microbiota transplantation in the treatment of inflammatory bowel disease.

Pectin is a soluble dietary fiber (DF), produced by the gut flora after a series of fermentation with many metabolites such as short chain fatty acids (SCFA) which supply the energy for epithelial cells, regulate intestinal PH and intestinal motility and join effort in immune regulation with intestinal lymphoid tissue. Previous studies showed that: water-soluble dietary fiber with the action of intestinal flora can cut the inflammatory cytokines, prevent inflammation and induce regulatory T cells, but the type and dose of dietary fiber used were different in different studies, and no studies have confirmed whether dietary fiber could adjusted the flora colonization ability in patients with IBD. We conceive that pectin by some mechanism to promote the migration of probiotics in intestine engraftment, reduce pathogenic agents' adhesion of intestinal mucosa, cut inflammation, and to maintain intestinal flora diversity and steady state in a long time, and than achieve the goal of continue to ease IBD.
The various embodiments herein relate to an injectable matrix used for regeneration, reconstruction, repair or replacement of organ or tissue. The injectable matrix consists of a synthetic and natural polymer, a stem cell niche and nanoparticles in the form of cups filled with growth factor and physiologic agent. The embodiments herein also provide a method for regeneration, reconstruction, repair or replacement of organ or tissue. In the method, an injectable matrix is injected to create three dimensional matrix system or network in an area of the desired tissue or organ, migration of blood circulatory stem cells or tissue-specific progenitor cells occur to the injected area of the tissue or organ. The growth factors and physiological agent present in the nanocups are released. The stem cells proliferate and differentiate to form the desired organ or tissue.
An air-purifying apparatus draws in an airflow from an ambient environment, kills germs in the airflow within the apparatus and expels the airflow purified back into the environment The apparatus has a housing with an interior chamber. An airflow enters the chamber through an inlet From the interior chamber, the airflow is expelled through an outlet. The apparatus has an airflow-germ-killing-system that kills germs in the airflow. The apparatus- has an airflow- generator which causes the airflow to flow from the inlet to the outlet. The airflow-germ-killing- system has a germ-killing-substance-effuser that effuses germ-killing-liquid-substance into the airflow. The germ-killing-liquid-substance comprises at least one antimicrobial agent.
BACKGROUND: Maintenance of physical function, mobility, and independent living are important goals for older adults. However, concerns about falling (CaF) play a central role in the vicious cycle of CaF, inflammation, loss of muscle mass, and decreasing physical function ultimately resulting in negative health outcomes. CaF, like other states of chronic stress and anxiety, can be considered as enduring adverse stimuli affecting the stress systems and the inflammatory system. Therefore, the aim of this study is to investigate whether a reduction of CaF leads to a reduction of stress and therefore possibly reduces chronic low-grade inflammation. Understanding the role and directionality of the effects of inflammation on CaF increases our understanding of age-related loss of mobility and physical function.
METHODS: In this study, community-dwelling older adults, aged 70 years and older, will be randomly assigned to either a 4-month, multi-component intervention with exercise training and cognitive-behavioral components or to a sham control group with light stretching exercises, cognitive training, and educational health lectures. For the operationalization of specific CaF, the Falls Efficacy Scale-International will be used. Stress and related psychological symptoms will be monitored using established self-reports and by measuring salivary cortisol. Concentrations of C-reactive protein, interleukin 6, interleukin 10, and tumor-necrosis-factor-alpha, as well as gene expression of selected inflammatory transcripts, will be used as surrogate parameters of the inflammatory status at baseline, after the 4-month intervention and 8-month follow-up.
DISCUSSION: This study will be the first to test whether CaF are related with stress system activity or reactivity or with markers of inflammation in the context of a multi-component intervention with exercise training and cognitive-behavioral components addressing CaF. The reduction of specific CaF or general psychological symptoms should reverse alterations in stress systems, and / or slow down low-grade inflammation. Changes in activity, as well as psychological and biological pathways leading from CaF to muscle loss will be measured, to disentangle the individual contribution to sarcopenia, and to provide an additional pathway to break or slow-down the vicious cycle of CaF and sarcopenia.
TRIAL REGISTRATION: German Clinical Trials Register (DRKS): DRKS00029171 . Registered 22 July 2022.
Subjects randomized to 5% human albumin for hemodynamic resuscitation. Volume will be decided based off of individual patient needs.
The invention discloses a small nucleic acid activator specifically enhancing miR-34a promoter transcriptional activity. The activator is designed according to a (-222nt, -201nt) nucleotide region of a miR-34a promoter sequence. According to the invention, 22 single-stranded small RNAs are designed aiming at the miR-34a promoter sequence. The small RNA can specifically activate miR-34a promoter transcription, such that the cancer-inhibiting gene in an organism is re-transcribed. Therefore, a novel method is provided for biological treatment of tumors. Also, the single-stranded small RNAs specifically start biological endogenous gene expression, such that tumor cell objective existing biological behaviors can be better simulated, and tumor molecular mechanism researches are more objective. Also, cell differentiation and individual development processes can be more realistically simulated, and in-vitro research on gene function can be more objectively carried out.
Danish departments of occupational medicine examine around 10,000 patients each year referred due to suspected work-related disorders. In Denmark and internationally there is a lack of follow-up studies investigating the long-term prognosis of employees with work-related disorders. The purpose of this cohort is to facilitate long-term prognostic studies for conditions such as mental or musculoskeletal disorders.

The Danish Occupational Medicine cohort has been created through The Danish National Patient Register and comprises all patients seen in Danish Departments of Occupational Medicine from 2000-2018 (N=145.521). Numerous register data are included in the database from five years prior to time of inclusion until 2018. Examples of register data are; information on work, sickness absence and disability as well as number and type of contacts to health services, use of medication, income, education, type of occupation, social status, death and cause of death. Job Exposure Matrices (JEMs) on physical and psychosocial work exposure, life styles and other matrices are also available. The cohort will be updated with new patients and register data regularly.
The invention belongs to the field of compositions, and particularly discloses a composition for preventing and treating constipation and application thereof. The composition comprises 20-40% of oligosaccharide, 35-45% of inulin and 20-35% of hawthorn extract by mass percentage. The composition can regulate intestinal microbial environment, is used for treating constipation, and has the advantages of remarkable curative effect, quick action, safety, no toxic or side effect, and no recurrence after disuse. The invention also provides food containing the composition, such as beverage, cake and other food. The disclosed beverage has good taste, is not added with any preservative, is suitable for long-term drinking, has high content of effective components, and can achieve good effect of relaxing bowel after long-term drinking. The disclosed cake and other foods also have the function of preventing and treating constipation.
PURPOSE:To obtain the titled preparation having improved rate of dissolution in intestines and capable of maintaining stable concentration in blood, by dissolving sulpiride and a methyl methacrylate/methacrylic acid copolymer in a solvent and completely removing the solvent from the solution. CONSTITUTION:A drug preparation containing 50-90wt% sulpiride can be prepared by dissolving sulpiride and a methyl methacrylate/methacrylic acid copolymer in a solvent (e.g. methanol) and completely removing the solvent from the solution. Sulpiride exhibits suppressive activity to subthalamic sympathetic nerve center to promote prophylactic factor and is useful also as an antiulcer agent or remedy for neurosis or depression, however, the solubility of sulpiride depends upon pH and is too low in the intestines to maintain the necessary concentration in blood. The removal of the solvent can be carried out e.g. by freeze-drying. The compound is amorphous by X-ray diffraction.
Participants received an intramuscular (IM) injection of CAB LA 400 mg and RPV LA 600 mg on week -4 during the Screening phase. Participants then received a sub-cutaneous (SC) injection of CAB LA 400 mg + RPV LA 600 mg on Day 1 of Week 1, Week 4 and Week 8 (once in every 4 weeks (Q4W)) for a total of 12 weeks during the SC abdominal Injection Phase. 4 weeks later, participants returned to the clinic for an IM gluteal injection (at Week 12) of CAB LA 400 mg + RPV LA 600 mg during the Return to Gluteal Injection Phase and subsequent gluteal injection occurred after Q4W at Week 16.
<P>PROBLEM TO BE SOLVED: To obtain an antitumor agent given by using a composite Chinese herbal medicine scarcely having side effects.  <P>SOLUTION: The antitumor agent is obtained by deacetylating various kinds of mushrooms, including ganoderma and agaricus, as raw materials, deoxygenating the deacetylated materials to form calcium β-glucan, making the calcium β-glucan easily soluble, mixing the Chinese herbal medicine, including ganoderma spawn, therewith, and further adding notoginseng radix, glycyrrhizin, tannic acid, monordicae fructus juice, saponin, or the like, thereto. A tungstate salt or a molybdate salt having bacteriostatic and fungistatic effects on bacteria, fungi, and viruses, or Adenophora pereskiaefolia is further added to the agent. Thus, the agent is effective for treating maxillary/submaxillary cancer, laryngeal cancer, lingual cancer, and uterine cancer which are conventionally not treated by single administration of the ganoderma or the agaricus, and has an immediate effect, when the Adenophora pereskiaefolia is together used. Therefore, the agent is effective for treating the cancers, without surgically treating the cancers.  <P>COPYRIGHT: (C)2004,JPO
Participants will undergo 16 sessions, twice a week on alternate days through the following Pilates Method exercises: Pelvic Curl, Leg lift Supine, One leg circle modified and Hundred modified. There will be 4 sets of 5 repetitions in the first week, 6 repetitions in the second week, 7 repetitions in the third week, 8 repetitions in the fourth week, 9 repetitions in the fifth week, 10 repetitions in the sixth to eighth week.
The present invention relates to novel imidazolidine derivatives of the formula I, in which B, E, W, Z, R, R0, R2. R3, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders, for example of rheumatoid arthritis, or of allergic disorders. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy or prophylaxis of illnesses which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or are associated therewith, or in which cell-cell or cell-matrix interactions which are based on interactions of VLA-4 receptors with their ligands play a part. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use in the therapy and prophylaxis of the disease states mentioned and pharmaceutical preparations which contain compounds of the formula I.
Fifteen years ago, public health experts urged industry, governments, and advocates to take action to dramatically improve the unhealthy food-marketing environment surrounding children in order to address the global childhood obesity crisis. Since then, research has confirmed that food marketing to children has far-reaching negative effects on their diets and health, takes advantage of adolescent vulnerabilities, and contributes to health disparities. In addition, digital marketing has profoundly changed young people's engagement with brands. Moreover, reliance on industry self-regulation as a solution has proven ineffective. Government-led policies have been more successful, but they remain limited in scope and challenging to adopt and implement. New approaches are necessary to increase public and policy maker awareness that food marketing is more than a nuisance, that it threatens the long-term health of children and adolescents worldwide, and that meaningful governmental action is urgently required to curtail industry's negative impact on young people's well-being.
Long-term use of glucocorticoids (GCs) is known to be a predominant cause of osteonecrosis of the femoral head (ONFH). Moreover, GCs can mediate apoptosis of various cell types by exaggerating oxidative stress. We have previously found that Cortistatin (CST) antagonizes oxidative stress and improves cell apoptosis in several conditions. In this study, we detected that the CST expression levels were diminished in patients with ONFH compared with femoral neck fracture (FNF). In addition, a GC-induced rat ONFH model was established, which impaired bone quality in the femoral head. Then, administration of CST attenuated these ONFH phenotypes. Furthermore, osteoblast and endothelial cells were cultured and stimulated with dexamethasone (Dex) in the presence or absence of recombinant CST. As a result, Dex induced impaired anabolic metabolism of osteoblasts and suppressed tube formation in endothelial cells, while additional treatment with CST reversed this damage to the cells. Moreover, blocking GHSR1a, a well-accepted receptor of CST, or blocking the AKT signaling pathway largely abolished the protective function of CST in Dex-induced disorder of the cells. Taken together, we indicate that CST has the capability to prevent GC-induced apoptosis and metabolic disorder of osteoblasts in the pathogenesis of ONFH via the GHSR1a/AKT signaling pathway.
Pilocarpine hydrochloride tablets, USP contain pilocarpine hydrochloride, a cholinergic agonist for oral use. Pilocarpine hydrochloride, USP is a hygroscopic, odorless, bitter tasting white crystal or powder, which is soluble in water and alcohol and virtually insoluble in most non-polar solvents. Pilocarpine hydrochloride, USP with a chemical name of (3S-cis)-2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl) methyl] monohydrochloride, has a molecular weight of 244.72.

Each 5 mg Pilocarpine Hydrochloride Tablet, USP for oral administration contains 5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet are microcrystalline cellulose and stearic acid, the tablet’s film coating is: polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc. 

Each 7.5 mg Pilocarpine Hydrochloride Tablet, USP for oral administration contains 7.5 mg of pilocarpine hydrochloride. Inactive ingredients in the tablet are microcrystalline cellulose and stearic acid, the tablet’s film coating is: FD&C Blue #2/Indigo Carmine aluminum lake, polyvinyl alcohol, titanium dioxide, polyethylene glycol, and talc.
Participants are required to compare each item on a computer screen to the item that they saw n-items back in the sequence. The participant plays a simple game where they control the movement of an astronaut that needs to collect correct gems, avoid incorrect gems, and also obstacles, to succeed at the game. If the participants performs well then they can be advanced to the 2-back, 3-back, 4-back, etc where they make similar matches but to earlier items in the sequence. This gamified task consists of a color n-back with 6 colors (a new color every 3 seconds, requiring subjects respond to targets by tapping the screen and navigating the astronaut to the targets, and avoiding the distractors) with 30% targets, and where the n-level will change every 2 minutes depending on performance (increase if performance is \>85% and decrease if \<75%). Sessions consist of 10 \~2 minute blocks, each with n-level as determined by the adaptive procedure and with user paced breaks between blocks.
Sarcoids are common mesenchymal neoplasms of horses. Although there are few studies in which sarcoids have been followed over a long period of time, sarcoids are considered locally invasive and have been reported to frequently recur following surgical excision. Currently, no histological features have been identified to predict which sarcoids will recur after excision. The present study comprised 49 sarcoids for which histology sections were available and in which the recurrence status of the case was known. Each sarcoid was excised from a different horse. Overall, 12 of the 49 (24%) sarcoids recurred after surgical excision. Mitotic count (MC), cellularity, necrosis, nuclear pleomorphism, and inflammation of the sarcoids were evaluated histologically. Of these, MC correlated with recurrence. Four of 5 (80%) sarcoids with an MC ≥ 20 in 2.37 mm2 recurred, which was a significantly higher recurrence rate than that of sarcoids with an MC < 20, 8 of 44 cases recurred (18%), P = .0051. Clinical type was also found to correlate with recurrence. Three of 4 (75%) fibroblastic types recurred, which was a significantly higher recurrence rate than that of sarcoids with other clinical types, 9 of 45 cases (18%), P < .001. In addition, univariate Cox regression analysis confirmed fibroblastic type and MC ≥ 20 as significant predictors for recurrence (P = .016 and P = .005, respectively). To the authors' knowledge, this is the first large study examining recurrence rates in sarcoids, and the first time that histological features have been correlated with recurrence.
PURPOSE:To improve kneading workability and to facilitate the unification with the bone tissue or teeth tissue of a living body, by compounding alkali metal salt or ammonium salt of citric acid with at least one of a powder agent, which consists of an alpha-tricalcium phosphate and a calcium hydroxide powder, and a curing liquid. CONSTITUTION:This curable composition consists of a powder agent, wherein an alpha-tricalcium phosphate powder and a calcium hydroxide powder are together used and a calcium oxide powder or, if necessary, a barium sulfate powder is further used, and a curing liquid, and alkali metal salt or ammonium salt of citric acid is compounded with at least one of the aforementioned powder agent and the curing liquid. The proper use amount of the calcium hydroxide or calcium oxide powder is 0.5-5wt.% of the alpha-tricalcium phosphate powder and the use amount of the barium sulfate powder is used within a range of 5-30wt.% of the alpha-tricalcium phosphate. The curing liquid is composed of a copolymer consisting of polyacrylic acid or acrylic acid and at least one of unsaturated carboxylic acid selected from a group consisting of methacrylic acid, maleic acid, fumaric acid and itaconic acid and the concn. of the aqueous solution of said copolymer is pred. within a range of 10-60wt.%.