anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Isolation comprises immunological sepn. of a homogenate or lysate, or of a suspension or soln. of the dry powder, of such cells, by antibody-antigen reaction with immunoglobulins (I). Fractions which have not reacted with (I) are sepd. by centrifuging, chromatography or electrophoresis. The antigen soln. to be processed, and that used to make (I), are pref. made by controlled chemical decompsn. of the biological tissue. Thus the powdered tissue is decomposed in a sealed reactor with a reagent of b.pt. at atmos. pressure normal temp., under such a vacuum that the reagent can transfer to the vapour phase. When the required decompsn. has been achieved, unused reagent is removed. The gaseous reagent is first deposited on the substrate by reducing the vacuum and, then after reaction, excess reagent is removed by increasing the vacuum. (I) are obtd. conventionally by immunising hosts with adult or juvenile tissue contg. no EF antigen. Tumour cells give a mixt. of EF and T antigens and the former are removed by repeating the process with EF-specific antibodies. The antigens are used to make antisera for prophylactic or therapeutic treatment of malignancies withour risking immunological disorders (by reaction with normal adult or juvenile antibodies).
Breastfeeding will begin 5 minutes before the Hepatitis-B vaccine administration and will continue during and after the procedure. It is planned to last 10 minutes in total.
Fasciolosis is an anthropozoonotic disease caused by the Trematoda  Fasciola hepatica . This worm is a common parasite of ruminants namely sheep, goats and cattle. Adult worms are usually found in the bile ducts of the final host liver, causing significant economic losses in the animal husbandry industry. The diagnosis of  Fasciola hepatica  infection, in definitive hosts, is usually done by microscopic identification of parasite eggs in the stools, observation of adult worms in liver ducts, or by serology. However, no diagnostic tool as been described for utilization directly in the animals in the farm. The disclosed subject matter describes a cDNA clone codifying for a 69 amino acids polypeptide and 8 kDa molecular weight, and identified as Fh8 or “fasciolin” (Genbank number AF213970). Results show that the polypeptide FH8 act as an allergen. The disclosed subject matter is directed to the detection of  Fasciola hepatica -infected definitive hosts using a skin application of “fasciolina” or related molecules obtained by mutation and chemical modification. The application system and the reading of the results can be specially executed for sheep and bovines, and it can be used in any kind of definitive host for this Trematoda. The test is easy to be used in field conditions and good results can be obtained faster.
The synthesis of fluorescent molecules with aggregation-induced emission (AIE) characteristics and application as fluorescent probes for cellular imaging, killing, and antibiotic screening, wherein the cells are bacteria or mammalian cells. The fluorescent molecules generate reactive oxygen species (ROS) upon light irradiation. A probe comprising fluorescent molecules exhibiting AIE phenomenon, wherein the probe is used for bacterial and biological study. A method of imaging and quantifying bacterial. A method of killing cells. A method of high throughput antibiotics screening and determining bacteria resistance. A method of photodynamic therapy. A method of determining critical micelle concentration.
BACKGROUND: Yellow rust (Puccinia striiformis f. sp. tritici) is a devastating hazard to wheat production, which poses a serious threat to yield and food security in the main wheat-producing areas in eastern China. It is necessary to monitor yellow rust progression during spring critical wheat growth periods to support its prediction by providing timely calibrations for disease prediction models and timely green prevention and control.
RESULTS: Three Sentinel-2 images for the disease during the three wheat growth periods (jointing, heading, and filling) were acquired. Spectral, texture, and color features were all extracted for each growth period disease. Then three period-specific feature sets were obtained. Given the differences in field disease epidemic status in the three periods, three period-targeted monitoring models were established to map yellow rust damage progression in spring and track its spatiotemporal change. The models' performance was then validated based on the disease field truth data during the three periods (87 for the jointing period, 183 for the heading period, and 155 for the filling period). The validation results revealed that the representation of the wheat yellow rust damage progression based on our monitoring model group was realistic and credible. The overall accuracy of the healthy and diseased pixel classification monitoring model at the jointing period reached 87.4%, and the coefficient of determination (R2) of the disease index regression monitoring models at the heading and filling periods was 0.77 (heading period) and 0.76 (filling period). The model-group-result-based spatiotemporal change detection of the yellow rust progression across the entire study area revealed that the area proportions conforming to the expected disease spatiotemporal development pattern during the jointing-to-heading period and the heading-to-filling period reached 98.2% and 84.4% respectively.
CONCLUSIONS: Our jointing, heading, and filling period-targeted monitoring model group overcomes the limitations of most existing monitoring models only based on single-phase remote sensing information. It performs well in revealing the wheat yellow rust spatiotemporal epidemic in spring, can timely update disease trends to optimize disease management, and provide a basis for disease prediction to timely correct model. © 2024 Society of Chemical Industry.
Peripheral pulmonary lesions (PPLs), which include pulmonary nodules and masses, are a common problem in pulmonology practice. The incidence of PPLs will likely increase given the growing adoption of chest CT screening for lung cancer. There are several guidelines available for management of PPLs. If bronchoscopy is selected as the method of diagnosis, conventional bronchoscopy has been one platform used for decades to diagnose PPLs. However, conventional bronchoscopic techniques have significant limitations and overall low diagnostic yield for most PPLs. As a result, innovative bronchoscopic techniques and technologies have evolved over the last decade to diagnose PPLs more accurately. However, accessing to PPLs located in the most peripheral part is still challenging.

As a new method to diagnose and localize cancers, photodynamic diagnosis (PDD) has been gaining attention. PDD is a new technique where a photosensitizer injected intravenously accumulates in the abnormal lesion, then its fluorescence can be detected by a detector. To conduct PDD for PPLs, we collaboratively developed a parallel-type composite optical fiberscope (COF) with an outer tip diameter of 0.97 mm with OK Fiber Technology (Kyoto, Japan). Its small size and flexibility of the tip enable it to be inserted into animal ultrasmall airways. The outer membrane of the fiberscope is made from polytetrafluoroethylene in the COF's insertable section and is hydrophilic coated, which reduces frictional forces when in the contact with the bronchial wall resulting in smooth insertion of the fiberscope. As the COF has illumination fibers and a laser fiber inside, simultaneous white-light and fluorescence imaging with real-time monitoring can be performed to confirm the tip position of the fiberscope during laser irradiation. In this study, we want to evaluate the COF regarding the quality of white-light images and the accessibility of lung tumors located in the peripheral area of the lung.
Cognitive impairment is not uncommon after stroke. Stroke patients with cognitive decline may experience difficulties in learning motor tasks, functional disability, and poor quality of life. Interventions for cognitive impairment remain under development and pharmaceutical intervention is not yet optimal at present. Targeted cognitive treatments or aerobic exercise training provided potential benefits to enhance cognitive function for stroke patients with cognitive decline. Recent studies demonstrate that combining exercise and cognitive training may provide additional benefits on cognition than single type of training. However, physical exercise training and cognitive-based intervention can be combined either sequentially or simultaneously. It remains unclear whether the two combination methods induce similar or differential effects in brain plasticity, physiological modulation, and behavioral outcomes for individuals with stroke. It is important to examine the potential effects, comparative effects and the neural mechanism of two combined interventions that can possibly maximize benefits for stroke survivors with cognitive impairments.

The purposes of the present study are to: (1) examine and compare the effects of two combined interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive, physical, and daily functions, and quality of life, from pre- to post-training; (2) understand the neural mechanisms of cognitive recovery following two combined interventions using the electroencephalography (EEG); (3) examine the long-term benefits following the two combined interventions; (4) to identify the correlations between brain activity, biomarkers and behavioral measures.
Systems and methods for rapid importation of data including temporally tracked object recognition. One of the methods includes receiving a request to authorize a prescription for a patient, the request being from a medical professional and the request being received of a network. The request is determined to be approved based on information associated with the patient. Transaction information is generated that is associated with the prescription, the transaction information specifying that the patient is authorized to obtain an associated pharmaceutical, and the transaction information being included in a transaction record associated with the patient. Authorization information associated with the prescription is generated, the authorization information being provided to a user device of the patient, and the authorization information enabling confirmation by an outside system that the prescription is authorized. Speech information associated with the prescription is presented on the user device of the patient, such that upon confirmation of presentation of the speech information, the transaction record associated with the patient is updated.
Endoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices have been developed to achieve these goals. The EndoRotor® Endoscopic Powered Resection System (Interscope Medical, Inc., Northbridge, Massachusetts, United States) is one such device. The EndoRotor is a powered resection tool for the removal of alimentary tract mucosa, including post-EMR persistent lesions with scarring, and has both CE Mark and FDA clearance. This review covers available published evidence documenting the usefulness of EndoRotor for the management of recurrent colorectal polyps.
The technology involves: a surgical image processing apparatus that allows images before and after a software update to be easily compared; an image processing method and a surgical system. The image processing unit performs image processing on the surgical site image through software. The display control unit controls display of the image of the surgical site subjected to the image processing. The image processing unit generates a pre-update processing image that is an image-processed surgical site image before the software update and a post-update processing image that is an image-processed surgical site image after the software update. The display control unit controls display of at least a portion of at least one of the pre-update processed image and the post-update processed image. The technique is applicable to the CCU of an endoscopic surgical system.
Kids (10-15 years old) with type 1 diabetes and one of their parents will receive the MyT1DHero app to use for a 3-month period. Participants are urged to use the app four times each day.
We will use a randomized experimental design to compare the effects of 3 different strategies to implement a prostate cancer screening decision support intervention (DESI) with a control condition in primary care in 2 clinical systems - PAMF (Palo Alto Medical Foundation) and UNC. The primary outcomes of interest are men's screening decisions and their subsequent healthcare utilization. Secondary outcomes include the likelihood that they review the DESI and their decision-specific knowledge. The 3 strategies selected by the PAMF and UNC health systems are: (1) mailing men a DESI in DVD; (2) inviting men to participate in a shared (group) medical appointment (SMA) to watch and discuss the DESI with a healthcare provider and other men; and (3) providing men options by inviting them to a SMA while also providing them a DESI in DVD which they can use individually if they are unable or choose not to attend a SMA. The 3 groups will be compared to a control condition that does not receive a DESI but will be encouraged to discuss prostate cancer screening with their physician. Because of its significantly larger patient population, the PAMF site will also evaluate these outcomes by targeting screening-naïve patients on their 50th birthday, when they first become guideline eligible to consider prostate cancer screening.
Clubroot, a soil-borne disease caused by Plasmodiophora brassicae, is one of the most destructive diseases of Brassica oleracea all over the world. However, the mechanism of clubroot resistance remains unclear. In this research, transcriptome sequencing was conducted on root samples from both resistant (R) and susceptible (S) B. oleracea plants infected by P. brassicae. Then the comparative analysis was carried out between the R and S samples at different time points during the infection stages to reveal clubroot resistance related pathways and candidate genes. Compared with 0 days after inoculation, a total of 4991 differential expressed genes were detected from the S pool, while only 2133 were found from the R pool. Gene function enrichment analysis found that the effector-triggered immunity played a major role in the R pool, while the pathogen-associated molecular pattern triggered immune response was stronger in the S pool. Simultaneously, candidate genes were identified through weighted gene co-expression network analysis, with Bol010786 (CNGC13) and Bol017921 (SD2-5) showing potential for conferring resistance to clubroot. The findings of this research provide valuable insights into the molecular mechanisms underlying clubroot resistance and present new avenues for further research aimed at enhancing the clubroot resistance of B. oleracea through breeding.
Patients will receive 200mg pembrolizumab on Day 1 of each 3 week cycle, for 2 cycles. Pembrolizumab will be administered via IV infusion for 30 minutes.Within the week (7 days +/- 3 days) following administration of the second cycle, a single 12 Gy dose of stereotactic radiation therapy (SRT) will be delivered to 50% of the primary tumor only. Definitive surgical resection will occur no later than 6 weeks following the last dose of pembrolizumab.
A teeth whitening dentifrice that enhances the shades of teeth with only a short application on the teeth. The dentifrice disrupts the surface tension between the teeth and the stains to provide with the aid of commonly known mechanical brushing and rising methods. 1 to 3 shades of whiter teeth. The toothpaste combines a non-polar solvent, a polar solvent, and a surfactant. An emulsion creates electrostatic interactions with the polar solvent and a reverse micelle to create a hydrophobic compound, which combines with the non-polar solvent to create a non-polar environment on the teeth. The polar solvent's strong electrostatic interactions in reverse micelles accelerate the removal of soluble material. The non-polar environment bonds with insoluble materials, such as extrinsic stains, to disrupt the surface tension between the teeth and the stain. Bleaching agents, thickeners, polishing agents, and other enhancers are mixed to the toothpaste to provide additional functions and characteristics.
The invention discloses a traditional Chinese medicine for treating cancers. The medicine is prepared with the raw materials of Artemisia apiacea, honeysuckle, Cassia tora, garden burnet root, sophora japonica, polyporus, raw hawthorn, coix seed, costustoot that are prepared into decoction which can promote appetite, enhance gasification ability, remove pathogenic heat from blood, stop bleeding and relieve pains. Radix notoginsen, safflower, antelope horn and agilawood are pulverized to make pills which have the effects of removing pathogenic heat from blood, removing the necrotic tissue and promoting granulation, reinforcing deficiency and supplementing qi, removing cancer masses rapidly. Pig bones, bovine bones, chicken bones, cony bones horse bones are disinfected, rinsed and cooked for 48 hours. Then the bones are discarded while the bone juice is retained. The bone juice is decocted with the decoction and pills into paste capable of controlling the increase and proliferation of cancer masses. Wherever the cancer masses transfer, the paste agent follows and wraps the cancer masses to minimize big masses and remove small masses. The medicine provided in the invention is applicable to various cancers with a cure rate of more than 50%, and cancers cured with the medicine are difficult to recur. The medicine is also characterized by little toxic side-effect and cancer prevention.
Participants are randomly assigned to 6-person peer networks in a mobile app. Participants in the social support condition could use an online chatting tool where they can send messages to their own network.
Although zidovudine (AZT) has shown promise in prolonging life in patients with AIDS and severe ARC, it has significant blood toxicities. It would be beneficial to combine AZT with another antiviral agent that does not have the same toxicity. DS might be a suitable drug since it has shown antiviral activity against HIV in the laboratory, and in preliminary studies it has shown little toxicity. Also, the combination of DS with AZT has been shown to be more effective than either alone.

The study will begin with 10 patients with AIDS, 10 with ARC, and 10 with asymptomatic HIV infection taking DS by mouth 3 times a day for 24 weeks. If the initial dose of DS is tolerated without significant side effects, the next group of patients will receive a higher dose. A third group of patients will be given either a higher or lower dose depending on the results of the earlier groups. Patients will be evaluated every other week for 12 weeks, then monthly for the remaining 16 weeks. Patients will have the option of continuing DS until the entire study is completed if the drug is well tolerated. Inhaled pentamidine for the prevention of Pneumocystis carinii pneumonia is allowed, but other investigational drugs are not. Drug effects on the HIV virus, immune function, and clinical condition will be monitored during the periodic evaluations.
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, namely to a method for displaying an electrocardiogram (ECG) waveform and a device for ECG analysis. At the same time, the measured ECG waveform is stored in the storage section. A set of signal segments is extracted from the stored waveform. The signal segments differ from each other over time. The set of segments is displayed on the screen in the form of candidate signals for analysis by the display control section. The arithmetic section is used to analyze the segment selected by the user among the set of segments displayed on the screen. The analysis result is displayed by the display control section on the same screen on which the set of the ECG waveform segments are displayed.EFFECT: verified using fewer procedures by displaying the analysis results of the ECG waveform simultaneously with the waveform screen of the analyzed object eliminating the need to switch screens. Displaying multiple candidate segments on a single screen makes it possible for the user to compare multiple candidates on a single screen and easily select the segment to record by selectively displaying analysis results related to each candidate segment.10 cl, 19 dwg
INTRODUCTION: This scoping review mapped evidence on physical activity (including structured exercise) and sedentary behaviour interventions (interventions to reduce sedentary behaviour) in people living with both frailty and multiple long-term conditions (MLTCs) and their informal carers.
METHODS: Ten databases and grey literature were searched from 2000 to October 2023. Two reviewers screened studies and one extracted data. Results were shared with three stakeholder groups (n = 21) in a consultation phase.
RESULTS: After screening, 155 papers from 144 studies (1 ongoing) were retained. The majority were randomised controlled trials (86, 55%). Participants' mean age was 73 ± 12 years, and 73% were of White ethnicity. MLTC and frailty measurement varied widely. Most participants were pre-to-moderately frail. Physical health conditions predominated over mental health conditions.Interventions focused on structured exercise (83 studies, 60%) or combined interventions (55 studies, 39%). Two (1%) and one (0.7%) focused solely on habitual physical activity or sedentary behaviour. Adherence was 81% (interquartile range 62%-89%) with goal setting, monitoring and support important to adherence. Carers were only involved in 15 (11%) studies. Most interventions reported positive outcomes, primarily focusing on body functions and structures.
CONCLUSIONS: A modest volume of evidence exists on multicomponent structured exercise interventions, with less focus on habitual physical activity and sedentary behaviour. Interventions report largely positive effects, but an updated systematic review is required. The field could be advanced by more rigorous characterisation of MLTCs, socioeconomic status and ethnicity, increased informal carer involvement and further evaluation of habitual physical activity and sedentary behaviour interventions.