anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pharmaceutical compositions which may be mixed with table salt to give a "medicated" product stable under conditions of high temperature and humidity consist of a salt of the antimalarials chloroquine or amodiaquine coated with a waxy or fatty substance having a melting point between 37 DEG  C. and 120 DEG  C., e.g. fatty alcohols or mixtures thereof, animal and vegetable fats and waxes, mineral waxes, long-chain fatty acids and their esters (including those with sorbitan and the mono- or di-polyoxyethylene esters), polyoxyethylene derivatives of partial esters of sorbitan, condensation products of fatty alcohols and ethylene oxide, esters of fatty alcohols with inorganic acids, fatty ethers, e.g. cetyl a -glyceryl ether, mineral and vegetable oils, optionally containing thickening agents or preservatives, hydrogenated vegetable or animal oils and natural or synthetic resins, e.g. shellac and cellulose acetate phthalate, such materials preferably having a melting point above 40 DEG  C.  Cetostearyl alcohol is stated to be particularly valuable.  Coating may be carried out by conventional procedures, e.g. addition of the coating material in solution in a volatile solvent to the drug and removal of the solvent by evaporation, spraying the drug with similar solutions whilst the drug is agitated or, when the melting point of the coating material is below about 120 DEG  C. by mixing the ingredients and heating to above the melting point of the waxy or fatty substance followed by cooling and comminution.
New pyridylmethyl thioethers I [R=(un)substd. alkyl or 5-or 6- membered heterocyclyl! and their therapeutcally accepeable acid-addn. salts were prepd. Thus, 11.2g 2-mercaptopyrimidine was reacted with 8.4g NaOH and later reacted with 16.4g 3-picolyl chloride at room temp. for 4hr. to give 45% thioester, 2-(pyridyl3-methylthio)- pyrimidine.HCl. I have bronchosecretolytic and muscolytic activity superior to those of ambroxolol. I can be used to creat acute and chronic respiratory diseases in the posttreatment of surgical interference with the respiratory tract and for all processes in which increased fluidity of the bronchial mucous is desired.
PURPOSE: A method for preparing lectin and/or Viscum album var. coloratum extract by radiation irradiation is provided to enhance immunity and to suppress tumor growth and transition. CONSTITUTION: A method for preparing Viscum album var. coloratum extract of low toxicity by radiation irradiation comprises: a step of adding Viscum album var. coloratum to distilled water and stirring; a step of centrifuging to obtain supernatant and filtering to obtain Viscum album var. coloratum extract; and a step of irradiating radiation to the Viscum album var. coloratum extract. A method for preparing lectin comprises: a step of isolating lectin from Viscum album var. coloratum and a step of irradiating radiation to lectin. A health food, immunoadjuvant, and anti-tumor agent contain Viscum album var. coloratum extract or lectin.
Systems and methods are described herein for processing electronic medical images to optimize a review order of pathology cases. For example, a plurality of variables and one or more constraints may be received along with a plurality of pathology cases. Each case of the plurality of pathology cases may include one or more medical images of at least one pathology specimen associated with a patient. The medical images from each case, the plurality of variables, and the one or more constraints may be provided as input to a trained system. A sequential order for user review of the plurality of cases to optimize one or more of the plurality of variables based on the one or more constraints may be received as output of the trained system. Each case of the plurality of cases may be automatically provided to a user for review according to the sequential order.
PURPOSE: Post-concussion syndrome (PCS) is commonly associated with dizziness and visual motion sensitivity. This case-control study set out to explore altered motion processing in PCS by measuring gaze stabilization as a reflection of the capacity of the brain to integrate motion, and it aimed to uncover mechanisms of injury where invasive subcortical recordings are not feasible.
METHODS: A total of 554 eye movements were analyzed in 10 PCS patients and nine healthy controls across 171 trials. Optokinetic and vestibulo-ocular reflexes were recorded using a head-mounted eye tracker while participants were exposed to visual, vestibular, and visuo-vestibular motion stimulations in the roll plane. Torsional and vergence eye movements were analyzed in terms of slow-phase velocities, gain, nystagmus frequency, and sensory-specific contributions toward gaze stabilization.
RESULTS: Participants expressed eye-movement responses consistent with expected gaze stabilization; slow phases were fastest for visuo-vestibular trials and slowest for visual stimulations (P < 0.001) and increased with stimulus acceleration (P < 0.001). Concussed patients demonstrated increased gain from visual input to gaze stabilization (P = 0.005), faster slow phases (P = 0.013), earlier nystagmus beats (P = 0.003), and higher relative visual influence over the gaze-stabilizing response (P = 0.001), presenting robust effect sizes despite the limited population size.
CONCLUSIONS: The enhanced neural responsiveness to visual motion in PCS, combined with semi-intact visuo-vestibular integration, presented a subcortical hierarchy for altered gaze stabilization. Drawing on comparable animal trials, findings suggest that concussed patients may suffer from diffuse injuries to inhibiting pathways for optokinetic information, likely early in the visuo-vestibular hierarchy of sensorimotor integration. These findings offer context for common but elusive symptoms, presenting a neurological explanation for motion sensitivity and visual vertigo in PCS.
PROBLEM TO BE SOLVED: To obtain a dentifrice composition for prevention of dental caries which shows continuously depressant effect for cariogenic bacteria derived from xylitol and is excellent in preventive effect for dental caries by formulating a specific alkali metal salt of organic acid along with xylitol. SOLUTION: This composition is composed of xylitol and a sodium polyacrylate. Xylitol is formulated in an amount of 1-60wt.% based on the whole composition. The sodium polyacrylate which shows viscosity of about 100-40,000cPs in the 0.5wt.% aqueous solution at 25 deg.C is preferable and additionally the bridge type one is effectively used. The formulating amount is about 0.01-3wt.% based on the whole composition. In addition, glycerol and propylene glycerol can be added into this composition as a mucilage. Further, xanthane gum and the like can be additionally formulated thereto as a caking additive.
Athletes report using social networking sites, including Instagram, to manage their self-presentations. While on Instagram, they may browse content and interact with others, enabling them to socially compare themselves to other athletes. Less favorable comparisons may contribute to higher burnout perceptions. The purpose of the current study was to (a) examine if the use of Instagram contributed to burnout perceptions and (b) if type of use and social comparison mediated these relationships. Male and female collegiate athletes (N = 162) completed measures of Instagram usage, social comparison, and burnout during their sport season. Latent path analysis using robust maximum likelihood estimation was used to examine the model. Daily time spent on Instagram was directly associated with exhaustion (β = -0.32) and reduced accomplishment (β = -0.21). Browsing was directly associated with exhaustion (β = 0.39), reduced accomplishment (β = 0.38), and sport devaluation (β = 0.27). Interacting was directly associated with devaluation (β = -0.23). Social comparison while using Instagram was directly associated with reduced accomplishment (β = -0.35) and devaluation (β = -0.34). Browsing mediated the relationship between time spent on Instagram and exhaustion (β = 0.13) and reduced accomplishment (β = 0.13). Social comparison was not a mediator. Results suggest that scrolling through posts on Instagram explains why time spent on the platform contributes to burnout perceptions. Comparing oneself favorably to others while using Instagram, independent of time spent on Instagram as well as type of use, may reduce burnout while comparing oneself unfavorably may enhance burnout perceptions.
Paclitaxel is administered intravenously over 1 hour on Days 1, 8, 15, and 22. Cisplatin will then be administered intravenously over 1 hour on Days 1 and 22. Radiation treatments will be given twice/day, on Days 1-5, 8-12 and 15-19. The subject's esophagus will be surgically removed on approximately Day #50. Approximately 4-6 weeks after surgery, the subject will start taking Tetrathiomolybdate, for 2 years or until treatment is no longer working to control your cancer. The subject will have blood drawn weekly while he/she is receiving chemotherapy and radiation prior to their surgery. 4-6 weeks after their surgery (when the subject starts taking Tetrathiomolybdate), a blood test will be performed every other week for 2 times, and monthly thereafter. When the level of copper has been lowered sufficiently an additional blood test and a baseline chest x-ray will be obtained. Additional blood will be drawn and tested every 6 months for the first 2 years.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to novel stable crystalline calcium or magnesium salts of (6R,S)-, (6S)- or (6R)-tetrahydrofolic acid, method of their preparing and a pharmaceutical composition based on thereof. Method of preparing the indicated salts involves crystallization of the corresponding tetrahydrofolic acid salt from polar medium at pH values from 7 to 10, at increased temperature mainly and/or from diluted solutions, in part, from water or its mixture with water- soluble solvent, for example, acetic acid or a lower organic alcohol. Invention relates to also a pharmaceutical composition comprising indicated salts. The proposed salts can be used as an agent regulating metabolic processes in body, as antagonists of the known antitumor preparations, for example, methotrexate, as an antidote for enhancement of tolerance of folic acid antagonists, for treatment of megaloblastic folate-dependent anemia and autoimmune diseases, for enhancement of tolerance of antiparasitic agents and for decrease of toxicity of dideazatetrahydrofolates in chemotherapy carrying out. EFFECT: improved method of preparing, valuable medicinal properties. 7 cl, 13 ex
The invention discloses a Penaeus monodon female parent shrimp gonad maturation-promoting small interfering RNA composition, which comprises small interfering RNAs of hormone genes for inhibiting gonad development of CHH, MIH and VIH3 of Penaeus monodon, wherein the three small interfering RNAs are CHH-siRNA, MIH-siRNA and VIH-siRNA, wherein the nucleotide sequence of a sense strand of the CHH-siRNA is shown as SEQ ID NO.1, and the nucleotide sequence of an antisense strand is shown as SEQ ID NO. 2; the sense strand nucleotide sequence of the MIH-siRNA is shown as SEQ ID NO.3, and the antisense strand nucleotide sequence is shown as SEQ ID NO. 4; the nucleotide sequence of the sense strand of VIH-siRNA is shown as SEQ ID NO.5, and the nucleotide sequence of the antisense strand is shown as SEQ ID NO. 6. The invention also discloses a gonad maturation promoting kit for the female parent shrimps of the penaeus monodon containing the small interfering RNA composition and a using method thereof. The small interfering RNA composition can obviously reduce the content of sex gland mature hormone inhibiting female parent shrimps, promote the generation of egg yolk protein and accelerate the development process of the sex gland.
OBJECTIVE: The present study evaluated whether minimally invasive approaches to orbital lesions could improve surgical, clinical, and aesthetic outcomes compared with more invasive ones. This is the first study specifically addressing this topic in children.
METHODS: Children consecutively operated on from January 2010 to January 2020 were analyzed. Thirty patients matched the inclusion criteria and were divided into group A: 14 cases treated with traditional surgical approaches; and group B: 16 cases managed by minimally invasive approaches.
RESULTS: There were no significant differences between the 2 groups in terms of demographic data and extent of tumor resection. Mean surgical time for the approach (40 minutes vs. 70 minutes, P < 0.0001), surgical complication such as periorbital edema (37% vs. 78%, P = 0.02) and dural tear (0 vs. 21%, P = 0.05), and procedures cost (P < 0.0001) were significantly reduced in group B. Regarding clinical outcomes, group B showed a significant reduction both in terms of postoperative pain (mean score based on visual pain scale was 2.9 vs. 4.1 P = 0.003) and mean hospitalization time (4.5 days vs. 5.5 days, P = 0.0004). The cosmetic outcome according to the Sloan classification was significantly better in group B as well (81% vs. 36% class I patients, P = 0.005).
CONCLUSIONS: The use of mini-invasive approaches to orbital tumor has clear advantages in terms of surgical, clinical, and cosmetic outcomes in comparable patients; therefore, they should be preferred whenever feasible. Craniotomic approaches remain necessary for very large tumors.
Participants will wear Bausch + Lomb investigational custom samfilcon B contact lenses daily for 3 months. Participants will be provided with ReNu MultiPlus Lubricating and Rewetting Drops for use as needed during the study. Participants will store their worn study lenses in a lens case filled with Biotrue multi-purpose solution (MPS).
Participants are asked to complete 12 brief, self-administered tablet computer sessions designed to improve decision-making around health risk behaviors. Sessions typically take about 10 minutes each to complete and are scheduled prior to or after probationer group or individual appointments at their probation facility. Sessions are scheduled about once per week.
The harmful effects of microplastics (MPs) on male fertility are receiving more and more attention. However, the impact of low-dose MPs exposure on the reproductive function of male mice is still unclear. In this study, we exposed male mice to low-dose MPs (25-30 μg/kg body weight/day) or low-dose MPs combined with high-fat diet (HFD) feeding. Our results showed that low-dose MPs exposure or HFD feeding significantly reduced sperm quality and the number of offspring born, while low-dose MPs exposure combined with HFD feeding further enhanced the above effects. The combination of low-dose MPs exposure and HFD feeding resulted in a notable elevation of inflammatory level within the prostate of mice and induced apoptosis of prostate epithelium and a decrease in nutrients (zinc, citrate) in seminal plasma fluid. Our findings in this study could provide valuable clues for better understanding the influence of low-dose MPs exposure on the reproductive system under metabolic disorders and facilitate the development of the prevention of reproductive toxicity caused by MPs exposure.
Subjects with systemic arterial hypertension in whom arterial pressure control was not achieved (24hr ambulatory pressure monitoring: mean 24hr systolic pressure \>/=130 mmHg or mean 24hr diastolic pressure \>/=80mmHg) by non-investigation specialized hypertensive unit care, in spite of appropriate drug treatment regimen with three or more anti-hypertensive drugs including a diuretic. Anti-hypertensive drug treatment was non-investigational and was prescribed at discretion of the physician who performed primary evaluation.
Self-management interventions (SMIs) may improve disease management in adults living with obesity. We formulated evidence-based recommendations for SMIs within the context of the COMPAR-EU project. The multidisciplinary panel selected critical outcomes based on the COMPAR-EU core outcome set and established decision thresholds for each outcome. Recommendations were informed by systematic reviews of effects, cost-effectiveness, and a contextual assessment. To assess the certainty of the evidence and formulate the recommendations, we used the GRADE approach guidance. Overall, SMIs were deemed to have a small impact, but the absence of harmful effects and potential cumulative benefits indicated a favourable balance of effects, despite low certainty. SMIs showed variations in structure, intensity, and resource utilisation, but overall are likely to be cost-effective. Adapting SMIs to local contexts would enhance equity, acceptability, and feasibility, considering patients' values, and availability of resources and teamwork. Consequently, the panel made conditional recommendations favouring SMIs over usual care. The rigorous and explicit recommendations demonstrated the effectiveness of SMIs for adults living with obesity. However, the gaps in the literature influenced the panel to make only conditional recommendations in favour of SMIs. Further research is needed to strengthen the evidence base and improve recommendations' certainty and applicability.
FIELD: medicine, gynecology. SUBSTANCE: method involves the use of natural preparation dry pantohematogen as a stimulating agent of immunity in patients with uterine appendages acute inflammatory diseases as one of link in pathogenesis of formation of chronic inflammatory process. Preparation is prescribed as abdominal-sacral electrophoresis of 0.3% solution of dry pantohenatogen and microenemas of 0.5% solution of dry pantohematogen. Treatment course is 10 days. Invention can be used for pharmacological correction of disorders in immunity system, mainly, in immune insufficiency in uterine appendages acute inflammatory diseases. EFFECT: broadened assortment of drugs, decreased adverse effects. 2 cl, 4 tbl, 3 ex
PURPOSE: This study aimed to develop a model for predicting the progression of inactive thyroid eye disease (TED).
METHODS: We retrospectively analyzed 107 patients with inactive TED, who did not receive any TED treatment during the follow-up period of 3-6 months. A multivariable regression analysis was employed to examine the clinical risk factors influencing the progress of TED and a predictive model based on risk factors was established.
RESULTS: Seventeen (15.9%) patients had progressed at the last observation. Male (p = 0.024), having smoking history (p = 0.009), compound indicator combined the duration of TED and immunosuppressive treatment history before 3 months (p = 0.026) and more severe diplopia (p = 0.015) were found to be the potential risk factors for progression. Among the subset of patients who exhibited progression, there was a notable escalation in the severity of proptosis (p = 0.021), margin reflex distance-1 (p = 0.031), and clinical activity score (p = 0.011). The multivariable stepwise regression analysis identified positive smoking history as well as untreated and having a duration of TED > 12 months as independent risk factors of TED progression. A predictive model including these risk factors was built, with the AUC (Area Under Curve) score of 0.783.
CONCLUSIONS: The predictors of TED progression include smoking history and composite indicators of duration time and treatment history. Our model may provide recommendations for immunosuppressive therapy and prognostic predictions for inactive TED patients preparing for surgery.
Skin cancer is the most common malignancy in the U.S. and the incidence and mortality from skin cancer is on the rise. Individuals can decrease their risk of skin cancer by engaging in protective behaviors such as limiting intentional and unintentional UV exposure, and wearing broad-spectrum sunscreens and protective clothing. Despite knowing the risks and receiving dermatological care, many patients with and without a history of skin cancer frequently forget to use UV protection or fail to use it in an optimal manner to reduce their UV risk. To address these concerns, Mallett and colleagues developed a 3-minute brief ABC intervention - Addressing Behavior Change. The ABC intervention is designed to be delivered by dermatologists in the context of a routine office visit involving a skin examination. Previous work by Mallett and colleagues showed dermatologists were highly motivated to deliver the intervention, quickly learned the requisite skills, delivered the intervention with fidelity, and showed minimal decay in knowledge, motivation, and skills over a 6-month period. This study builds on a previous study by conducting an examination of the efficacy of the ABC intervention on patients' motivations and behaviors utilizing a prospective longitudinal design.
A household-based prospective cohort study will be conducted from 2021 to 2025 in northern Taiwan. We will invite 240 households, having a baby who is discharged from MacKay children's Hospital. The households will be classified into nuclear family type and extended family type. The "Nuclear family type" is defined as husband and wife with baby (aged less than 5 months) and with or without children (2-5) and the "Extended family type" (three-generation family) is defined as husband and wife with baby (aged less than 5 months), children (2-5), and grandparents aged \> 65 years old. We will initially complete an enrollment form to collect baseline data, including patient demographics, prior medical history, season when discharge, neonatal course and households. A LINE-based management will be done weekly by study team to see if there are any respiratory symptoms in household. In addition to the monthly physician weekly LINE response, the research nurse will contact the parents or legal guardians by telephone monthly for the 24 months to obtain data on changes in baseline information, and specific facts regarding possible respiratory infections after the last contact. If the households present with respiratory symptoms, the visit will be arranged as early as possible. When they presenting to the emergency department, outpatient clinic, or inpatient ward, the urine will be collected for the serotype-specific urinary antigen detection (SSUAD) assays and the nasopharyngeal or throat swab for polymerase chain reaction will be performed to study serotype of S. pneumoniae and Respiratory syncytial virus subgroup. If the subjects who have clinical syndromes suggestive of pneumonia or bronchopneumonia, they will be asked to participate in the further study along with their household family members. Nasopharyngeal aspiration, urine, blood, and induced sputum will be collected for cultures, polymerase chain reaction and serological test. Clinical manifestations, disease course, and outcomes will be recorded. Family members in the same household will asked to undergo screening with a nasopharyngeal or throat swab and urine sample. We will trace back 2-week contact history of children in nuclear family who get Respiratory syncytial virus or pneumococcal infections, especially focus on other family members. The data will be further analyzed to evaluate the influence of short period and long period contact.
The present invention relates to medicine for promoting fracture union, which is characterized in that the medicament is prepared from the raw materials of the following weight percentages: 25 to 35% of fortune's drynaria rhizome, 15 to 25% of sanchi and 40 to 60% of membranous milkvetch root. The present invention also discloses a preparation method of the medicine for promoting fracture union. The medicine of the present invention is Chinese patent medicine with the advantages of scientific and reasonable prescription and obvious pharmacological action. The medicine is used for accelerating healing after fractures, and reinforcing anti-fracture strength. The effective component content of the medicine of the present invention is high, and the medicine is prepared by the method of the present invention. Besides, the curative effect of the medicine of the present invention can be further improved.