anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a new reverse transcriptase inhibitor and an antiviral agent containing low-molecular weight active and low toxic ingredient(s) having distinct structure. CONSTITUTION:This reverse transcriptase inhibitor or an antiviral agent contains, as active ingredient(s), a sulfated tyrosine of the formula (Z<1> and Z<2> are such that one of them is SO3H, the other being SO3H or H) and/or a physiologically permissible salt thereof. The compound of the formula is pref. the one where Z<1> and Z<2> are each SO3H, and the salt is e.g. Na, K, Ca, Mg, Ba or tetrabutylammonium salt. The compound of the formula is obtained by enzymatically or chemically treating tyrosine (e.g. decomposition of a sulfated tyrosine-contg. protein, sulfuric esterification of tyrosine). Since the molecular weight of this compound, is lower than those of conventional sulfonated polyamino acids, its antigenicity and shacks in injection thereof can be avoided.
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a wolfberry polysaccharide chewable tablet for relieving chronic fatigue syndrome. The raw materials of the wolfberry polysaccharide chewable tablet for relieving the chronic fatigue syndrome comprise 20-30% of wolfberry polysaccharide and the balance of pharmaceutically acceptable auxiliary materials in percentage by mass. The invention also provides application of the lycium barbarum polysaccharide in preparing a medicament for relieving chronic fatigue syndrome. The medlar polysaccharide chewable tablet disclosed by the invention has the advantages of sweet and sour taste, convenience in taking and carrying, no need of water for taking, no need of disintegration, high absorption speed and high drug dissolution, and is more suitable for children, old people and dysphagia patients. The medlar polysaccharide chewable tablet has strong drug effect, can be directly used for relieving chronic fatigue syndrome, and greatly improves the bioavailability. The invention discovers that the lycium barbarum polysaccharide has the function of relieving chronic fatigue syndrome, develops a new application of the lycium barbarum polysaccharide, and improves the utilization value of the lycium barbarum polysaccharide.
The invention discloses a traditional Chinese medicine dispersible tablet for treating upper respiratory infection, and a preparation method and a quality detection method thereof. The traditional Chinese medicine dispersible tablet is a solid preparation manufactured by scutellaria baicalensis extract, gardenia extract and pharmaceutic adjuvant of proper proportion according to proper preparation processes. The traditional Chinese medicine dispersible tablet not only can effectively resist virus and kill bacteria, but also has the effects of clearing internal heat, being anti-inflammation, easing pain and the like. Compared with conventional tablets, the traditional Chinese medicine dispersible tablet has the characteristics of being good in mouthfeel, fast to absorb, quick in effect, strong in action, convenient to administrate, and the like. The invention further discloses a quality detection method of the traditional Chinese medicine dispersible tablet. The quality detection method comprises three parts of authentication, check and content determination. With the quality detection method disclosed by the invention, the quality control standard of the dispersible tablet can be improved, and the clinically curative effect of the traditional Chinese medicine dispersible tablet can be fully ensured.
A composition that softens at a predetermined temperature between about 20oC and about 62oC, comprising at least one block copolymer having at least two thermal transition temperatures. The composition is characterized by at least two thermal transition temperatures, one of which is a predetermined lower transition temperature between about 20oC to about 62oC and one of which is an upper transition temperature above about 62oC. The composition has the physical properties of a rigid, crystalline or glassy polymer below the predetermined transition temperature and the physical properties of a flexible, rubbery polymer at and above the predetermined transition temperature, but below the upper transiiton temperature. In a preferred embodiment, the composition of the present invention further comprises a plasticizer or polymer that has at least one thermal transition temperature and is thermodynamically compatible with at least one block of the block copolymer. For most biomedical applications, the composition of the present invention has a predetermined glass transition temperature at or near body temperature. The present invention also provides a method of making the composition, a method of making biomedical devices and materials and articles with shape-memory properties from the composition, and biomedical devices and materials and articles with shape-memory properties made from the composition.
PURPOSE: Urolithiasis is a chronic condition that leads to repeated CT scans throughout the patient's life. The goal was to assess the diagnostic performance and image quality of submillisievert abdominopelvic computed tomography (CT) using deep learning-based image reconstruction (DLIR) in urolithiasis.
METHODS: 57 patients with suspected urolithiasis underwent both non-contrast low-dose (LD) and ULD abdominopelvic CT. Raw image data of ULD CT were reconstructed using hybrid iterative reconstruction (ASIR-V 70%) and high-strength-level DLIR (DLIR-H). The performance of ULD CT for the detection of urinary stones was assessed by two readers and compared with LD CT with ASIR-V 70% as a reference standard. Image quality was assessed subjectively and objectively.
RESULTS: 266 stones were detected in 38 patients. Mean effective dose was 0.59 mSv for ULD CT and 1.96 mSv for LD CT. For diagnostic performance, sensitivity and specificity were 89% and 94%, respectively, for ULDCT with DLIR-H. There was an almost perfect intra-observer concordance on ULD CT with DLIR-H versus LDCT with ASIR-V 70% (ICC = 0.90 and 0.90 for the two readers). Image noise was significantly lower and signal-to-noise ratio significantly higher with DLIR-H compared to ASIR-V 70%. Subjective image quality was also significantly better with ULDCT with DLIR-H.
CONCLUSION: ULD CT with Deep Learning Image Reconstruction maintains a good diagnostic performance in urolithiasis, with better image quality than hybrid iterative reconstruction and a significant radiation dose reduction.
The PDT/Lucentis trial will be a Phase IV comparative trial comparing the use of combination therapy with ITV ranibizumab and verteporfin PDT to ITV ranibizumab alone in patients with exudative AMD. Patients will be randomized to one of three groups. All patients will receive three consecutive monthly treatments with ITV ranibizumab. Patients randomized to group I will receive only ITV ranibizumab. Patients randomized to group II will also receive one treatment with reduced fluence (20% fluence) verteporfin PDT at day 0. Patients randomized to group III will also receive one treatment with reduced fluence (40% fluence) vPDT. All patients will also be evaluated for possible retreatment with ranibizumab according to established criteria. Thirty patients (ten per group) will be recruited from one U.S. sites in a 6-month period. Randomization will occur at the time of entry into the study. Follow-up will continue until month 12 (from day 0) in all subjects.
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to preparations containing an organic active compound, in part, the use of allantoin as an antioxidant. Administration of exogenous allantoin increases additional pool of antioxidants in living cell and blood plasma and enhances body resistance to oxidative stress. Proposed anti-oxidant can be used as a medicinal agent and food supplement preventing the development of free radical processes and impairment of antioxidant defense system in living organisms. EFFECT: enhanced effectiveness of antioxidant, broadened arsenal of agents with antioxidant properties. 2 tbl
Clinical trial protocols frequently need to be amended during a clinical trial, but the amendments are costly and can delay new drug approval. It is challenging to avoid, reduce or minimize incidences of amendments. Currently, people have to manually identify flaws of protocol, which is slow and may incur errors due to subjective perspectives and lack of objective, sufficient, and structured data. The present invention discloses an integrated clinical trial design and design optimization platform that efficiently reduces/minimizes incidences of amendments. In one embodiment, the protocol design or optimization is based on data. In one embodiment, the result is more accurate, quantitative and less error-prone; the system can quickly identify flaws; the flaws can be detected at an earlier stage and the system can distinguish key and leading factors and variables, helping sponsors identify the most efficient amendment.
Early Letter + Portrait Arm received a Portrait + Therapeutics Letter with the initial mailing (September 23, 2021). At the delayed mailing (March 28, 2022), Early Letter + Portrait Arm received nothing.
The present invention discloses a pure natural health-care product, namely complete pearl shell powder which is composed of water-soluble marine pearl layer powder and marine pearl shell meat powder. The complete pearl shell powder contains various kinds of amino acid necessary for human bodies, 19 kinds of amino acid of a large amount of taurine, etc. and 28 kinds of elements of a large amount of calcium, phosphorus, magnesium, kalium, ferrum, zinc, selenium, germanium, etc. The animal experiment verifies that the health-care product has the efficacy of reducing blood fat, resisting fatigue, etc. The complete pearl shell powder can enhance the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in vivo, increase the numbers of leucocytes and thrombocytes and enhance the immunological functions of human bodies and the action of aging resistance, etc., and furthermore, the medicinal nutrient value is extremely obvious. The product can be widely used for the industries of beverage, foods, medicines, daily chemical industrial products, etc.
Dofetilide had no genotoxic effects, with or without metabolic activation, based on the bacterial mutation assay and tests of cytogenetic aberrations in vivo in mouse bone marrow and in vitro in human lymphocytes. Rats and mice treated with dofetilide in the diet for two years showed no evidence of an increased incidence of tumors compared to controls. The highest dofetilide dose administered for 24 months was 10 mg/kg/day to rats and 20 mg/kg/day to mice. Mean dofetilide AUCs(0–24hr) at these doses were about 26 and 10 times, respectively, the maximum likely human AUC.

There was no effect on mating or fertility when dofetilide was administered to male and female rats at doses as high as 1.0 mg/kg/day, a dose that would be expected to provide a mean dofetilide AUC(0–24hr) about 3 times the maximum likely human AUC. Increased incidences of testicular atrophy and epididymal oligospermia and a reduction in testicular weight were, however, observed in other studies in rats. Reduced testicular weight and increased incidence of testicular atrophy were also consistent findings in dogs and mice. The no effect doses for these findings in chronic administration studies in these 3 species (3, 0.1, and 6 mg/kg/day) were associated with mean dofetilide AUCs that were about 4, 1.3, and 3 times the maximum likely human AUC, respectively.
FIELD: medicine, phytotherapy, chemical-pharmaceutical industry, pharmacy. SUBSTANCE: invention relates to preparations of vegetable origin and methods of their preparing. Invention proposes tincture based on vegetable raw used for treatment of osseous-articular diseases. Dried rhizomes or herb, or mixture of rhizomes and herb of plant Comarum palustre L. are used as raw. Also, invention proposes agent for treatment of osseous-articular diseases based on vegetable raw containing powder of extractive substances obtained by 10-80% an aqueous-spirituous extraction of Comarum palustre L. Agent based on dried extract for treatment of osseous-articular diseases containing extractive substances obtained by 10-80% an aqueous-spirituous extraction of Comarum palustre L. and 2-80% ethyl alcohol is developed. Agent comprises components taken in the following ratio, wt.-%: Comarum palustre L. extractive substances, 0.1-12.0; 2-80% ethyl alcohol, the balance. Invention proposes also method of extraction of Comarum palustre L. with 2-80% ethyl alcohol using whole or milled dried rhizomes or herb or mixture of rhizomes and herb of Comarum palustre L. Ratio of leaves and rhizomes is taken from 1:10 to 10:1 and extraction is carried out from 1 h to 21 days by maceration or percolation or other known methods. Then extract is settled to concentration 5-30% of air-dried substances. Pharmacological effect of claimed tincture and agents based on dry extract obtained by the claimed method from swampy marsh cinquefoil is confirmed by clinical investigations. Analysis of clinical material obtained as result of application of tincture and agents based on dry extract indicates that proposed preparations are useful mainly in diseases of osseous-articular etiology: osteochondrosis, gout, radiculitis, rheumatism of different etiology, polyarthritis, ischiasis, arthritis, different inflammatory processes in articulars. Preparation can be used also in liver and cholalic ways diseases, gastroenteric and cardiovascular diseases, lung tuberculosis and different oncological diseases. EFFECT: improved method of preparing, valuable medicinal properties of agent. 8 cl
PROBLEM TO BE SOLVED: To obtain the subject agent capable of simultaneously conducting straight permanent waving and hair manicuring in a short time with no coloring on the skin due to hair manicuring, by formulating a straight permanent waving 2nd agent with a specific dye. SOLUTION: This agent is obtained by formulating a 2nd agent for straight permanent waving with 0.1-5 (esp. 0.2-1)wt.% of an acid dye such as nitro dye, azo dye, nitroso dye, triphenylmethane dye or xanthene dye, and pref. furthermore, about 5-10wt.% of an oxidizing agent such as a bromate, perborate or hydrogen peroxide. Besides, formulation of about 1-10wt.% of an alcohol such as ethanol or isopropyl alcohol in this agent improves the hair dying power of this agent. According to this invention, as the hair swells by the action of a 1st agent to effect a status where the inside of the hair becomes facile in the intake of any matter, application of this 2nd agent to the resultant hair can yield sufficient hair dyeing effect even at pH7.
FIELD: biotechnology, genetic engineering, molecular biology, virology, medicine. SUBSTANCE: invention presents strain of recombinant smallpox vaccine and recombinant plasmid DNA pTBI-HBsAg. Recombinant plasmid DNA encodes nine immunogenic epitopes of two main structural proteins of human immunodeficiency virus of type-1. Recombinant strain of smallpox vaccine modified with plasmid pTBI-HBsAg induces T- and B-cellular immune response against HBsAg and HIV-1 in animals vaccinated by its. Strain can be used as a base for mixed vaccine against HIV-1 and human hepatitis B virus and orthopoxviruses. EFFECT: valuable antiviral properties of strain. 3 dwg, 3 tbl, 3 ex
PURPOSE:To prepare a spongy drug base suitable as the base of a sheet for applying to the oral mucosa, etc., by forming a mixture of a specific natural or semi-synthetic polymer, a synthetic polymer, and a plasticizer, to a spongy form. CONSTITUTION:A mixture consisting of (A) (pref. 30-80wt% of) a natural or semi-synthetic polymer having a viscosity of >=100 cp in the 5% aqueous solution and exhibits adhesivity when dissolved in or gelled with water, (B) (pref. 10- 30wt% of) a synthetic polymer having a molecular weight of >=10,000 which dissolves in or gels with water, and (C) (pref. 5-30wt% of) a water-soluble, non- volatile plasticizer, is formed to a spongy form. The combined use of the above components improves the adhesivity, flexibility, and strength of the base, elongates the effectivity of the drug component, and improves the feeling of the applied parts.
BACKGROUND: In the United States (US), premature cardiovascular disease (CVD) mortality rates (35-74 years) have exhibited increases in recent years, particularly in younger adults, and large differentials by educational attainment. This trend has occurred concurrently with high and increasing obesity prevalence, which also show significant differences by education. This study aims to jointly model premature CVD mortality trends in the US according to obesity status and educational attainment.
METHODS: We used multiple cause of death data from the National Center for Health Statistics, obesity prevalence data from the National Health and Nutrition Examination Survey (NHANES), and educational attainment data from the American Community Survey and NHANES. We applied Bayes' theorem to these data to calculate the conditional probability of premature CVD mortality given obesity status and educational attainment for 2003-2019. We then projected this conditional probability for 2020-2029 using the Lee-Carter model.
RESULTS: The probability of premature CVD mortality was greatest for obesity and low education (not graduated high school) and was substantially higher (females 6.7 times higher, males 5.9) compared with non-obesity and high education (Bachelor's degree or higher) in 2019. There was a widening of the gap in premature CVD mortality from 2003 to 2019 between the obese and non-obese populations, which occurred at each education level and was projected to continue in 2020-2029, especially for males. The conditional probability of premature CVD death for obesity and middle education (finished high school but no Bachelor's degree) increased substantially and was projected to surpass the level for non-obesity and low education in coming years for males and in younger age groups. At high education, the conditional probability of premature CVD death for the obese population was projected to increase to 2029, while for non-obesity it was projected to remain steady for females and fall for males; this projected widening is greatest at older age groups.
CONCLUSIONS: The findings demonstrate the public health challenge to reduce premature US CVD mortality posed by continued high obesity prevalence, especially for younger ages, lower education groups and males. The relative importance of obesity in influencing premature CVD mortality trends has risen partly due to the decline in CVD mortality attributable to other risk factors.
Invasive candidiasis and candidemia remain a significant public health concern. The European Confederation of Medical Mycology (ECMM) conducted three pan-European multicentre studies from 1997 to 2022 to investigate various aspects of invasive Candida infections. These studies revealed shifting trends in Candida species distribution, with an increase of non-albicans Candida species as causative pathogens, increasing rates of antifungal resistance, and persistently high mortality rates. Despite advancements in antifungal treatment, the persistently high mortality rate and increasing drug resistance, as well as limited drug access in low-income countries, underscore the need for continued research and development in the treatment of Candida infections. This review aims to summarize the findings of the three completed ECMM Candida studies and emphasize the importance of continued research efforts. Additionally, it introduces the upcoming ECMM Candida IV study, which will focus on assessing candidemia caused by non-albicans Candida species, including Candida auris, investigating antifungal resistance and tolerance, and evaluating novel treatment modalities on a global scale.
Disclosed herein is a ketogenic food composition and methods thereof. The ketogenic food composition promotes ketogenesis in a subject in need thereof. The ketogenic food composition includes fat, protein, and carbohydrate. A ratio of fat to a combination of protein and carbohydrate in the ketogenic food composition may be about 2.5:1 to about 4.5:1. The ketogenic food composition may be a sole diet for the subject. Also provided herein is a method of treating a disease in a subject in need thereof. The method includes administering the ketogenic food composition to the subject. The disease may be a cancer or an obesity-related disorder.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease of the nose and paranasal sinuses characterized by mucosal thickening and polyp formation¹ which are inflammatory lesions that project into the nasal airway and are typically bilateral² .Chronic rhinosinsitis with nasal ployps (CRSwNP) affects 0.5% to 4% of the population worldwide. ³ Symptoms include anterior or posterior rhinorrhea, nasal congestion, hyposmia, and/or facial pressure or pain that last for a duration of more than 12 weeks.² The cause of the sinonasal polyps is still unknown but they may be associated with several pathological conditions i.e. infection, allergic fungal sinusitis, allergy and cystic fibrosis ⁴. Many studies were based on detection of bacterial and fungal growth in sinonasal polyps , and found that preoperative bacterial culture showed growth of Staphylococcus coagulase negative (CONS) ,Staphylococcus aureus , gram -ve bacteria i.e. Pseudomonas aeruginosa , Klebsiella pneumoniae , Klebsiella ozenae and Escherichia coli⁴ . From fungi , Aspergillus species were the most commonly recovered isolates ⁵. The initial approach of management was medical treatment . Medical therapy consists of administration of intranasal or systemic steroids. Other medical treatments considered the use of antibiotics, leukotriene modifiers, and avoidance of acetylsalicylic acid. Surgical removal was performed for non-responders to medical management⁶. Functional endoscopic sinus surgery (FESS) is a minimally invasive technique in which sinus air cells and sinus ostia are opened under direct visualization. The goal of this procedure is to restore ventilation and normal functions⁷.
Pramipexole, by mouth. Dosing will be initiated at 0.25 mg on night one, followed by 0.25 mg twice-a-day day two onward, and increased every week to a target of 4.5 mg/day for the 12-week duration of the study.
The invention relates to a preparation method of medical ozone ice, which comprises the following steps: S1. preparing double distilled water or ultrapure water, and injecting the double distilled water or ultrapure water into a closed container; S2. introducing ozone gas into the double distilled water or ultrapure water in the step S1 until the ozone is saturated and dissolved, thereby obtaining ozone water; and S3. filling the ozone water in the step S2 into ice making molds, and carrying out fast freezing to obtain the medical ozone ice. The method is quick and efficient. The prepared ozone ice is low in production cost and convenient to use, can be used for treating oral diseases, infective dermatosis and the like, receives good reputation from broad users, and has huge market value.
A typical guar extract, commercially available as a white powder, contains 80-82% galacto mannanes, 11-14% moisture, 3.5-4% protein, 0.8-3% fibres, 0.3-0.7% ether extractable and 0.5-0.8% ash. The pref compsn is 1.8-1.9% guar extract, 2-3% soya lecithin, 3-7% plant extract and the remainder water. Pref plants fore the extract are burdock, sage, willow, rosemary and calendula; the extract also pref contains kernel oil esp of almonds, nuts or raisins the kernel oil is pref used to extract the plants. The compsn pref also contains a preservative. It is easily prepd from the constituents giving a stable emulsion even without the addn of a synthetic emulsifier. It rehydrates the hair and makes it supple and is also used as a hand cream.