anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present disclosure is related to a Histone H3 Clipping by a cathepsin C-like protease as a new epigenetic mechanism used by P. falciparum to control DNA replication. Post-translational modifications (PTMs) of histone N-terminal tails are key epigenetic regulators of gene expression in the human malaria parasite Plasmodium falciparum. Here, we identify developmentally controlled proteolytic clipping of the N-terminus of histone H3 at amino acid position 21 by a cathepsin C-like protease termed dipeptidyl aminopeptidase 2 (PfDPAP2) as a new PTM in intra-erythrocytic parasite stages. Conditionally knocked down PfDPAP2 abrogated histone H3 clipping and blocked intra-erythrocytic parasite DNA replication. Correspondingly, genome-wide occupancy of clipped histone H3 identified the upstream regions of several DNA replication genes as targets of this essential protease. Because episomally expressed clipped histone H3 showed nucleosomal incorporation at similar genomic loci as the endogenous clipped protein, this points to a novel type of nucleosome replacement mechanism in P. falciparum. The discovery of an unprecedented protease-mediated, epigenetic control mechanism of DNA replication makes PfDPAP2 a promising therapeutic target to develop anti-malarials.
This was randomized parallel group controlled clinical trial where arms, not patients were the unit of randomization. This trial was funded by the Craig H. Neilsen Allied Health Professional Development Award of the American Spinal Injury Association (ASIA). This research was conducted at a 32-bed spinal cord injury and multi-trauma rehabilitation unit in an urban center. Participants were recruited from an inpatient spinal cord injury rehabilitation unit. Eligible participants were 18 years or older and undergoing acute rehabilitation after a cervical spinal cord injury with hand function impairment, and the primary occupational therapist deemed splinting intervention was required. Each eligible extremity was randomized to receive a custom or pre-fabricated resting hand splint for night use.
AIS due to large vessel occlusion (LVO) remains a substantial cause of mortality and morbidity. Recent guidelines have recommended MT as the first-line therapy for AIS-LVO in the anterior circulation. Thrombectomy using a stent retriever is safe and effective in the treatment of AIS. As a new generation of stent retriever, Embotrap stent retriever has a unique design including an open outer cage for clot capture and a closed inner channel for clot stabilization. Previous studies showed Embotrap stent retriever can achieve a successful recanalization of 88% and favorable outcome of 51%. Also, the Multicenter ARISE II Study showed the first-pass effect of EmboTrap stent retriever was 40.1%, higher than other stent retrievers, such as Solitaire FR and Trevo device. But most studies were single-armed without direct comparison. Thus, this prospective cohort study is designed to compare the safety and efficacy of Embotrap stent retriever with other stent retrievers without inner channel.
The study will include 2 visits separated by a maximum of 7 days. During the first visit, subjects' characteristics will be documented by a locally validated questionnaire. Allergy skin prick tests, spirometry, methacholine inhalation test and induced sputum will also be done. Asthma and rhinitis control will be evaluated by locally validated questionnaires, the Asthma Control Scoring System (ACSS) and the Rhinitis Control Scoring System (RCSS), respectively. Nasal peak inspiratory flow (NPIF) and oral peak expiratory flow (PEF) will also be recorded to obtain the nasal blockage index (NBI). On the second visit, nasal biopsies will be taken.
Cohort 2 will include subjects for whom a peripheral intravenous line placement is not part of routine pre-operative care. Average age for cohort 2 is age less than 7 years old. Procedures for Cohort 2 will include a gastric US measurement of the antral CSA and gastric volume using Perlas US qualitative grading assessment by an expert and a novice operator to determine the inter-rater class reliability and repeat measurements by each operator for the intra-rater reliability (Aim 1). This cohort is included to examine the reliability of measurements across age groups.
Patient-centered self-management program for patients with hypertensive nephropathy into 4 units, including: Unit 1: hypertensive nephropathy brief introduction and complications. Unit 2: dietary precautions for patients with hypertensive nephropathy. Unit 3: medication treatments for patients with hypertensive nephropathy. Unit 4: the content included stress management (emotional control, spiritual support). This program was implemented in small groups with 5-10 patients. This study used patient-centered self-management group activity manual as the tool. The group activities with 4 units lasting for 400 minutes were expected to be designed. The group activities were expected to last for 4 weeks and be implemented once per week and 100 minutes per time (including: 90 minutes of group discussion and 5-10 minutes of video-waring).
INTRODUCTION: Chronic kidney disease (CKD) in stages 3-5 without albuminuria occurs more often in women than in men; however, most patients initiating and receiving kidney replacement therapy are men. Sex-determined biological factors and gender-related aspects both likely account for this discrepancy. Patient opinions on gender-related discrepancies in kidney care have not been investigated.
METHODS: Building upon the findings of semi-structured interviews previously conducted with CKD patients and their caregivers, two questionnaires were developed to investigate patient behavior and opinions relating to gender and CKD. These questionnaires containing 39 items were distributed to eight outpatient clinics in Austria. Responses were descriptively analyzed and compared between genders, as well as between age-groups and CKD stages.
RESULTS: Questionnaires from 783 patients and 98 caregivers were included in the analysis and covered health awareness and self-management of disease, the impact of gender roles and gender equality, and patient autonomy and trust in the health-care system. A total of 56.1% of men patients and 63.1% of women patients found that women were better at looking after their health compared to men (41.1%/34.3% no difference, 2.8%/2.6% men better). A total of 95.4% of men patients, 95.0% of women patients, 100% of men caregivers, and 95.5% of women caregivers stated that all patients with kidney disease were treated completely equally, irrespective of gender.
CONCLUSION: Neither the patients nor the caregivers stated gender-determined treatment decisions in CKD care. Both men and women however agreed that women are better at maintaining their own health and excel in disease self-management.
DETROL LA Capsules 2 mg were evaluated in 29 patients in a Phase 2 dose-effect study. DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, 12-week study. A total of 507 patients received DETROL LA 4 mg once daily in the morning and 508 received placebo. The majority of patients were Caucasian (95%) and female (81%), with a mean age of 61 years (range, 20 to 93 years). In the study, 642 patients (42%) were 65 to 93 years of age. The study included patients known to be responsive to tolterodine immediate release and other anticholinergic medications, however, 47% of patients never received prior pharmacotherapy for overactive bladder. At study entry, 97% of patients had at least 5 urge incontinence episodes per week and 91% of patients had 8 or more micturitions per day. 

The primary efficacy assessment was change in mean number of incontinence episodes per week at week 12 from baseline. Secondary efficacy measures included change in mean number of micturitions per day and mean volume voided per micturition at week 12 from baseline.

Patients treated with DETROL LA experienced a statistically significant decrease in number of urinary incontinence per week from baseline to last assessment (week 12) compared with placebo as well as a decrease in the average daily urinary frequency and an increase in the average urine volume per void.

Mean change from baseline in weekly incontinence episodes, urinary frequency, and volume voided between placebo and DETROL LA are summarized in Table 4.
Globally implant therapy is currently accepted as a predictable, viable and successful option to replace missing teeth.As a result, the focus in contemporary implant dentistry has shifted towards the optimization of treatment concepts with aesthetics and function as an important outcome parameter.In this respect, implant installation should be prosthetically -driven, at the same time taking into account anatomical limitations as well as restrictions in terms of bone availability. Apart from aesthetics, a correct implant position may reduce biological and technical complications, favourable esthetic and prosthetic outcome, long term stability of peri-implant tissues, optimal occlusal contacts and implant loading. One possible tool that may facilitate a more accurate implant positioning is guided implant surgery.Virtual implant planning facilitates desired inter implant distance and depth. A top down planning wherein digital images of the edentulous area and mock wax up of the prosthesis is superimposed, allows precise implant placement planning. This digital planning can be converted into a surgical/virtual guide via a 3D printer or a milling machine.Fully guided surgery is based on a surgical guide which will assist the clinician in every step of the surgery starting from the first drill to the implant placement through the use of guiding sleeves in the guide. A partially-guided protocol differs only in the final step: after guided preparation of the osteotomy, the guide is removed and the implant is installed free-handedly.Therefore, the aim of this randomized controlled clinical trial is to investigate the accuracy of implant position achieved with static CAIP(Computer Assisted Implant Placement) and to compare this with the accuracy of conventional cast based partially guided implant placement(cPGIP).
Patients undergo MRI and fan beam CT (FBCT) at baseline, within the first 3 weeks of radiotherapy and between week 4 and 6 of radiotherapy. Patients with lung cancer may undergo 4D cone beam x-ray CT (CBCT) on the same day as the second and third MRI and FBCT.
The invention provides a medicine which can be used to effectively treat swine high fever. The drug efficacy components are produced with the raw materials in the following parts by weight: gypsum is 100 to 200 parts, scutellaria is 80 to 150 parts, dried rehmannia root is 80 to 150 parts, moutan bark is 80 to 150 parts, atractylodes rhizome is 80 to 150 parts, phellodendron bark is 80 to 150 parts, cape jasmine is 80 to 150 parts, and rhubarb is 80 to 150 parts. Together with a pharmaceutically acceptable carrier, the medicine can be produced into various dosage forms, such as powder, mixture, tablets, capsules as well as granules, etc. The medicine is suitable for symptoms of damp heat accumulation, high fever, spirit depression, inappetence, cough and dyspnea, disturbance in respiration, even pneumonia, and constipation which are caused by gradual intrusion of toxic heat into nutrient and blood, and induced weak fetus, even dead fetus and mummy fetus, etc. when the toxic heat attacks pregnant pigs. The medicine has good curative effect for weanling pigs, fattening pigs and brood sows, and the total effectiveness rate is up to 85 percent.
A novel complex of polypyrrolidone, also known as nylon-4, and iodine is disclosed. The complex has biocidal properties exhibiting especially the fungicidal and bactericidal properties of free iodine but not its irritating and toxic properties. The complex may be formed with polypyrrolidone having any physical form, e.g. a powder, film, pulp, fiber or molded article. Bandage material made from nylon-4 fibers and complexed with iodine is a particularly useful form. Ointments and other compositions for topical application may also be made.
Six-session health education group program designed as a health education curriculum for teenagers. The program is facilitated by a psychologist. Sessions are weekly for 1-hour.
The control group will receive general health advice every 3 months based on their physical examination and blood results. They will be provided information on the vascular risk factors for dementia and will receive instruction and handouts on diet and exercise.
Participants in this arm will receive PEEPS plus usual care. PEEPS is comprised of eight weekly two-hour sessions delivered to groups of 6-10 participants. The sessions provide education on endometriosis, mindfulness, yoga, nutrition, and strategies to cope with chronic pain. Participants additionally receive peer and clinician support.
BACKGROUND: Traumatic brain injury (TBI) is often underreported or undetected in prehospital civilian and military settings. This study evaluated the incidence of TBI within the Prehospital Trauma Registry (PHTR) system.
METHODS: We reviewed PHTR and the linked Department of Defense Trauma Registry (DoDTR) records of casualties from January 2003 through May 2019 for diagnostic data and surgical reports.
RESULTS: A total of 709 casualties met inclusion criteria. The most common mechanism was blast, including 328 (51%) in the non-TBI and 45 (63%) in the TBI cohorts. The median injury severity scores in the non-TBI and TBI cohorts were 5 and 14, respectively. The survival scores in the non-TBI and TBI cohorts were 98% and 92%, respectively. Subdural hematomas, followed by subarachnoid hemorrhages were the most common classifiable brain injuries. Other nonspecific TBIs occurred in 85% of the TBI cohort casualties. Seventy-two cases (10%) were documented by the Role 1 clinician. Based on coding or operative data, 15 of the 72 (21%) were identified as TBIs. Of the 637 cases, which could not be decided based on coding or operative data, TBI was suspected in 42 (7%) cases based on Role 1 records.
CONCLUSIONS: Over 1 in 10 casualties presenting to a Role 1 facility had a TBI requiring transfer to a higher level of care. Our findings suggest the need for improved diagnostic technologies and documentation systems at Role 1 facilities for accurate TBI diagnosis and reporting.
<P>PROBLEM TO BE SOLVED: To provide a carbon dioxide gas-generating tool exhibiting excellent sustained release of carbon dioxide gas, and sustaining the state of generating the carbon dioxide gas over a long period.  <P>SOLUTION: The carbon dioxide gas-generating tool 1 is obtained by sealing a carbon dioxide gas-generating body 2 having a carbon dioxide gas-generating part 21 in a bag body 3 comprising a slightly carbon dioxide gas-permeable sheet. The carbon dioxide gas-generating part 21 is constituted by including a sheet obtained by impregnating an aqueous solution of a hydrogen carbonate salt having concentration of 0.5-5 mol/L of the hydrogen carbonate salt. The carbon dioxide gas-generating body 2 has a storing body 22 for storing the carbon dioxide gas-generating part 21, and the storing body 22 includes a gas-permeable sheet having 10-15,000 s/100 cc of gas permeability prescribed by JIS P8117 and ≤6,000 g/(m<SP>2</SP>×24 h) of moisture permeability prescribed by JIS Z0208. An aqueous solution of sodium hydrogen carbonate or an aqueous solution of potassium hydrogen carbonate is preferable as the aqueous solution of the hydrogen carbonate salt.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Hypercapnic respiratory failure is a prevalent medical problem, comprising a substantial number of ED visits and readmissions. The target population that are at high risk for developing hypercapnia are patients with obesity hypoventilation syndrome (OHS), chronic obstructive pulmonary disease (COPD), sleep disordered breathing (SDB) overlapping with COPD, and patients with neuromuscular disorders. These patients are commonly managed in the progressive care units or the intensive care unit for extended periods of time, which can over-utilize health systems resources. Einstein Medical Center's patient population includes multiple low-income communities / neighborhoods. Their educational background varies and constant education and counseling is an integral part of the treatment plan. These patients are particularly vulnerable due to a lack of geographic access and difficulty contacting healthcare providers via phone. Some of the patients may not be able to afford co-pays for clinic visits or are not able to follow up with a physician. In addition, patients treated with non-invasive ventilation in the hospital and require home therapy either never receive the device or are sub-optimally trained in its appropriate utilization. These patients may also be morbidly obese with mobility issues, which is another obstacle preventing patients from following up with their providers.

Positive airway pressure (PAP) therapy/ non-invasive positive pressure ventilation (NIPPV) are effective treatments to avoid acute hypercapnic respiratory failure; however, low compliance and poor follow-up are often recurring issues. These high-risk patients present in the emergency department acutely hypercapnic and encephalopathic with subsequent ICU admission and mechanical ventilation.This Telemedicine Outreach Program aims to utilize E-touch devices (Vivify-Go) in collaboration with home visits by EMS (Emergency medical services) to improve compliance and the efficiency of healthcare delivery. These efforts will hopefully lead to a decrease in acute decompensated respiratory states and hospital readmission rates.
Fully human anti-PD-L1 antibodies and their corresponding uses are disclosed. Fully human antibodies are capable of specifically binding to human PD-L1. Antibodies were obtained by employing screening techniques based on yeast display libraries and by affinity maturation to further improve their affinity for PD-L1. The fully human anti-PD-L1 antibody disclosed showed good specificity, affinity and stability. They are capable of enhancing T cell activity by binding to activated T cells while significantly inhibiting tumor growth. The fully human anti-PD-L1 antibodies disclosed are useful for the diagnosis and treatment of PD-L1 related cancers and other related diseases.
A local ethics committee has approved the study. A statistical power calculation was performed and 177 patients per group will be necessary to confirm a 20% difference of efficacy of the block at 30 minutes (α=0,05; β=0,1). Epidural catheter will be inserted and a standardized analgesic protocol will initiate. The efficacy of the block will be assessed after 30 minutes and at delivery. The apparition of adverse effects during puncture and labour will be annotated. The need for repuncture of the block and the repercussion of the technique on the delivery and the fetus will be recorded as well. At 24 hours, investigators will assess the incidence of pain at the site of puncture (PSP) and the level of maternal satisfaction on a 0 to10 numeric scale.
PURPOSE:To provide a solid cosmetic containing fine powder of titanium oxide and truly spherical titanium oxide each having respective specific particle diameter, having unique structural characteristics and shear-embrittling property and excellent masking power, spreadable smoothly on the skin and having excellent adhesivity. CONSTITUTION:The objective solid cosmetic having excellent embrittling property and useful especially as a makeup cosmetic can be produced by coordinating (A) a fine particle of titanium oxide having the maximum particle diameter of <=0.1mum and average particle diameter of 0.01-0.05mu in the space between (B) the truly spherical titanium oxide particles having an average particle diameter of 1-30mu, preferably 4-20mu. The weight ratio of A:B in the solid cosmetic base is 1:10-10:1, and the sum of both components is 5-80wt%. EFFECT:The cosmetic has excellent durability on the skin and gives powdery feeling free from oiliness to the skin. It has no stickiness and high adhesivity to the skin. In can be transferred to the cosmetic tool such as puff, brush, etc., or to the skin in the case of direct application.
Group receiving placebo: Each man will receive placebo oral mixture once after blood- and semen sampling and performed DXA scan. Thereafter they will receive placebo tablets daily for 3 months. At 3 months a clinical control and blood sampling will be performed, followed by continued daily intake of placebo. At end of treatment at five months after inclusion the men deliver two semen samples, have a blood sample drawn and a DEXA scan performed.
PURPOSE:A composition for the oral cavity, obtained by incorporating a sweet perfume, e.g. anise oil, and a sweetening agent, e.g. stevioside, in combination with a composition containing a polishing agent, binder, surfactant, fluorine- containing compound, enzyme, germicide, etc., and having improved taste and feeling of use. CONSTITUTION:A composition for the oral cavity, obtained by incorporating a sweet perfume selected from anise oil, fennel oil, anethole, amyl formate, and ethyl butyrate, etc. and a sweetening agent selected from stevioside, rebaudioside, osladin, perillartine, etc. in combination with a composition for the oral cavity, e.g. toothpaste, mouthwash, prophylaxis paste, etc. The use of the above- mentioned two components provides the aimed composition for the oral cavity, capable of masking an unfavorable taste of a polishing agent, binder, surfactant, fluorine-containing compound, enzyme, antiplasmin agent and germicide, etc., and having a good taste and improved feeling of use.
Outcomes for children with acute lymphoblastic leukemia (ALL) have improved worldwide to >85%. For those who relapse, outcomes have remained static at ~50% making relapsed acute lymphoblastic leukemia one of the leading causes of death in childhood cancers. Those relapsing within 18 mo in the bone marrow have a particularly dismal outcome. The mainstay of treatment is chemotherapy, local radiotherapy with or without hematopoietic stem cell transplantation (HSCT). Improved biological understanding of mechanisms of relapse and drug resistance, use of innovative strategies to identify the most effective and least toxic treatment regimens and global partnerships are needed to improve outcomes in these patients. Over the last decade, new therapeutic options and strategies have been developed for relapsed ALL including immunotherapies and cellular therapies. It is imperative to understand how and when to use these newer approaches in relapsed ALL. Increasingly, integrated precision oncology strategies are being used to individualize treatment of patients with relapsed ALL, especially in patients with poor response disease.
Photic ocular injuries are secondary traumatic injuries resulting from the toxic effects of the interaction between light and the eye, particularly the retina. We report the cases of two patients who experienced photic macular injury from their early childhood due to observing a solar eclipse without protection. The retinal lesions are mainly macular; these can be serious and irreversible. They are the consequence of photochemical, photomechanical and photothermal reactions. OCT is very useful for the diagnosis of these foveal lesions. The visual prognosis of solar retinopathy is generally favorable. However, some patients may develop permanent sequelae with a decrease in visual acuity. Management remains empirical and controversial. Thus, prevention and public education remain the only effective ways to avoid this type of trauma.