anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Undifferentiated small round cell sarcomas (USRS) of bone and soft tissue are a group of tumors with heterogenic genomic alterations sharing similar morphology. In the present study, we performed a comparative large-scale proteomic analysis of USRS (n = 42) with diverse genomic translocations including classic Ewing sarcomas with EWSR1::FLI1 fusions (n = 24) or EWSR1::ERG fusions (n = 4), sarcomas with an EWSR1 rearrangement (n = 2), CIC::DUX4 fusion (n = 8), as well as tumors classified as USRS with no genetic data available (n = 4). Proteins extracted from formalin-fixed, paraffin-embedded pretherapeutic biopsies were analyzed qualitatively and quantitatively using shotgun mass spectrometry (MS). More than 8000 protein groups could be quantified using data-independent acquisition. Unsupervised hierarchical cluster analysis based on proteomic data allowed stratification of the 42 cases into distinct groups reflecting the different molecular genotypes. Protein signatures that significantly correlated with the respective genomic translocations were identified and used to generate a heatmap of all 42 sarcomas with assignment of cases with unknown molecular genetic data to either the EWSR1- or CIC-rearranged groups. MS-based prediction of sarcoma subtypes was molecularly confirmed in 2 cases where next-generation sequencing was technically feasible. MS also detected proteins routinely used in the immunohistochemical approach for the differential diagnosis of USRS. BCL11B highly expressed in Ewing sarcomas, and BACH2 as well as ETS-1 highly expressed in CIC::DUX4-associated sarcomas, were among proteins identified by the present proteomic study, and were chosen for immunohistochemical confirmation of MS data in our study cohort. Differential expressions of these 3 markers in the 2 genetic groups were further validated in an independent cohort of n = 34 USRS. Finally, our proteomic results point toward diverging signaling pathways in the different USRS subgroups.
PROBLEM TO BE SOLVED: To obtain the subject composition with high germicidal power and favorable appearance, useful for preventing periodontosis and dental caries, by making the composition include cetylpyridinium chloride and a specific polyoxyethylene cetyl ether to prevent the cetylpyridinium chloride from hampering its adsorption to the teeth surface. SOLUTION: This composition is obtained by including (A) pref. 0.001-0.5 wt.% of cetylpyridinium chloride and (B) pref. 0.1-1.5 wt.% of a polyoxyethylene cetyl ether with the number of addition moles of ethylene oxide of 10-30 (pref. 15-20) on average. This composition can be prepared to such formulations as mouthwash, dental rinse and dilution-type mouthwash.
Disclosed is a C-type fluoroscopy apparatus with an automatic reading interlocking function with a remote specialized reading institution. According to the present invention, the C-type fluoroscopy apparatus comprises a C-type fluoroscopy unit and a photographed image transmission communication member. Photographed image information formed in the C-type fluoroscopy unit can be automatically transmitted to a specialized reading institution at a remote location spaced apart from a hospital where the C-type fluoroscopy unit is installed. Reading result information, which is a result of image reading for the photographed image information by the specialized reading institution in the remote location, is transmitted from the specialized reading institution in the remote location to the photographed image transmission communication member. The photographed image transmission communication member can automatically upload the reading result information to a medical image information system (picture archiving and communication system (PACS)) of the hospital where the C-type fluoroscopy unit is installed. Accordingly, the photographed image information obtained through photographing of a patient to be photographed in a hospital and uploaded to a medical image information system of the hospital can be automatically transmitted to a specialized reading institution in the remote location.
An epidural catheter sited preoperatively so analgesics can be administered postoperatively. Patients were titrated on a continuous analgesic epidural infusion rate until stable pain scores of ≤ 3 were reached while in PACU (as described in the PCEA group). Once stable, they were allocated to their preoperatively determined randomization assignment which for the CEA group meant they remained on the continuous background epidural infusion rate previously determined to maintain pain scores ≤ 3 while in PACU. Rescue analgesia was available as needed.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic having an excellent unhairing- preventing effect, an excellent trichogenous effect, and an excellent effect for preventing the itch and dandruff of scalp and further excellent in safety by compounding a specific essential oil and a specific amineoxide. SOLUTION: This cosmetic contains (A) an essential oil ingredient capable of being used as a refreshing agent [e.g. a menthol compound (e.g. l-menthol) and/or a camphor (e.g. d-camphor)] and (B) dimethylamine oxide of the formula. In the objective composition, the ingredients A and B are preferably contained in 0.001-5.0 wt.% and 0.0001-20.0 wt.%, respectively, based on the whole cosmetic. The ingredients may be administered at a daily dose of 0.001-100 mg per kg of a general adult body with two to four portions a day.
NEW MATERIAL:An alkaloid compound expressed by formula I (X is H, OH or acetoxy; Y if formula II or III). USE:A medicine and bacterial inhibitor capable of exhibiting improved activity inhibitory action on Gram-positive bacteria, e.g. Staphylococcus aureus or Bacillus subtilis. PREPARATION:Sponge which is a product of OKINAWA, etc., is crushed, homogenized and extracted with a solvent, e.g. ethanol, etc., at room temperature, purified and isolated by column chromatography to give a compound expressed by formula I (X is H and Y is formula II or X is OH and Y is formula III), which is then acetylated in the presence of acetic anhydride and triethylamine in a solvent, e.g. chloroform, etc., to afford the aimed compound expressed by formula I (X is OCH3 and Y is formula II).
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Removal of third molars in healthy patients is considered a procedure with a low risk of bleeding. However, exactly how low the incidence of postoperative bleeding is remains unclear due to the heterogeneity of available studies. To determine the exact postoperative risk of bleeding after the removal of third molars in healthy patients, a prospective observational multicentre study was conducted. A total of 1,035 patients with complete follow-up was included. Of these, 329 patients reported subsequent bleeding, but did not consult their attending physician. A total of 15 patients visited the hospital, 8 of whom required minimally invasive (re)treatment. No hospitalizations were necessary. There was a large difference between the incidence of postoperative bleeding reported by patients and postoperative bleeding requiring clinical examination and/or treatment. To reduce this difference in future, patients should be given detailed information about what degree of postoperative bleeding is considered normal after removal of a third molar.
The present invention relates to a complete granule for treating hepatocirrhosis and liver ascites and a preparation process thereof, which provides a medicine for treating hepatocirrhosis and liver ascites. The medicinal preparation is prepared from 9 kinds of traditional Chinese medicinal materials including bupleurum root, scutellaria root, frog, etc. and Kaixilai chemical medicinal preparations. The preparation process of the complete granule for treating hepatocirrhosis and liver ascites is approximately divided into steaming and boiling the traditional Chinese medicinal materials, filtering, distilling, concentrating, drying to obtain medicinal powder, pulverizing the chemical medicinal preparations, sieving, uniformly mixing, preparing soft materials, screening, granulating, stoving, packaging, etc. The present invention has the advantages of reasonable prescription, obvious complementation, simple preparation process, low cost, short treatment period, obvious therapeutic effect and no toxic or side effect. Matched with the injection of abdominal cavities for treatment, the present invention has special effect on hepatocirrhosis and liver ascites.
PS-CoV will be defined as individuals with a history of molecular testing confirmed COVID-19 infection, recovered from acute infection but with ongoing symptoms (self-reported, pulmonary, cardiac, musculoskeletal or other symptoms) of at least 4 weeks' duration. Recovery from acute infection will be defined according to provincial health guidelines: at least 10 days' (14 in those hospitalized; 21 in those with immunocompromise) from onset of symptoms with at least 24 hours without a fever, without taking anti-pyretic medications and improvement of other symptoms.
PRCIS: Peripapillary retinoschisis (PPRS) may bias optical coherence tomography's (OCT) monitoring of glaucoma progression. Its impact on glaucoma still remains uncertain. Only 2 out of the 10 included studies illustrated a correlation between PPRS and glaucoma progression.
OBJECTIVES: The frequent use of OCT increased the detection of PPRS, which poses challenges in the follow-up of patients with glaucoma. This systematic review aims to summarize the literature regarding PPRS in glaucoma, exploring its prevalence, impact on disease, and clinical management implications.
METHODS: We searched PubMed, Embase, Web of Science, and Scopus with tailored search queries for each platform. All studies had to report PPRS in patients with glaucoma. Exclusion criteria included studies with <10 eyes, studies focusing on schisis outside the disc area, with concomitant retinal or optic nerve lesions, with animals, reviews, studies written in non-English language, and congress abstracts.
RESULTS: Ten studies were included, of which 7 were case-control, one was a cohort study, and 2 were case series.Six studies showed that PPRS often overlapped preexisting retinal nerve fiber layer defects. One study reported that the de novo development of PPRS was more frequent in eyes with glaucoma progression than in eyes without progression.Visual field findings were inconsistent, with just one study (out of 6) showing that patients with glaucoma with PPRS experienced faster visual field deterioration than those without it. Overall, solely 2 studies (out of 7) associated PPRS with faster glaucoma progression.
CONCLUSIONS: PPRS biases OCT analysis in glaucoma. Caution is needed against overestimation of retinal nerve fiber layer thickness when PPRS develops and misinterpretation of its resolution as rapid progression. PPRS' exact impact on glaucoma progression remains unclear.
BACKGROUND: Adherence with follow-up appointments after a pediatric intensive care unit (PICU) admission is likely a key component in managing post-PICU sequalae. However, prior work on PICU follow-up adherence is limited. The objective of this study is to identify hospitalization characteristics, discharge child health metrics, and follow-up characteristics associated with full adherence with recommended follow-up at a quaternary care center after a PICU admission due to respiratory failure.
METHODS: We conducted a retrospective cohort study of patients ≤ 18 years with respiratory failure admitted between 1/2013-12/2014 to a quaternary care PICU. Post-hospitalization full adherence with recommended follow-up in the two years post discharge (1/2013-3/2017) at the quaternary care center was quantified and compared by demographics, baseline child health metrics, hospitalization characteristics, discharge child health metrics, and follow-up characteristics in bivariate and multivariate analyses. Patients were dichotomized into being non-adherent with follow-up (patients who attended less than 100% of recommended appointments at the quaternary care center) and fully adherent (patients who attended 100% of recommended appointments at the quaternary care center).
RESULTS: Of 155 patients alive at hospital discharge, 140 (90.3%) were recommended to follow-up at the quaternary care center. Of the 140 patients with recommended follow-up at the quaternary care center, 32.1% were non-adherent with follow-up and 67.9% were fully adherent. In a multivariable logistic regression model, each additional recommended unique follow-up appointment was associated with lower odds of being fully adherent with follow-up (OR 0.74, 95% CI 0.60-0.91, p = 0.005), and each 10% increase in the proportion of appointments scheduled before discharge was associated with higher odds of being fully adherent with follow-up (OR 1.02, 95% CI 1.01-1.03, p = 0.004).
CONCLUSIONS: After admission for acute respiratory failure, only two-thirds of children were fully adherent with recommended follow-up at a quaternary care center. Our findings suggest that limiting the recommended follow-up to only key essential healthcare providers and working to schedule as many appointments as possible before discharge could improve follow-up adherence. However, a better understanding of the factors that lead to non-adherence with follow-up appointments is needed to inform broader system-level approaches could help improve PICU follow-up adherence.
<P>PROBLEM TO BE SOLVED: To provide a composition having lipolysis-promoting activities or the like.  <P>SOLUTION: The extract of Gentianella alborosea extracted from the Gentianella alborosea has activities for inhibiting cyclic AMP phosphodiesterase activities, SOD-like activities, activities for inhibiting hyaluronidase activities, and activities for inhibiting the isolation of hexosaminidase. The extract of the Gentianella alborosea also has activities for inhibiting tyrosinase activities, activities for inhibiting production of melanin by a B16 melanoma cell, activities for inhibiting MMP-1 activities, activities like estrogen, activities for promoting production of collagen, and activities for proliferating dermal fibroblast. The extract of the Gentianella alborosea has activities for inhibiting the activities of testosterone 5α-reductase, and antagonistic activities to an androgen receptor. The extract is useful for prevention of overweight by the promotion of lipolysis, antioxidation, anti-inflammation, bleaching, prevention of gray hair, antiaging and hair growing.  <P>COPYRIGHT: (C)2007,JPO&INPIT
AIMS: The main objective in this study was to determine the prevalence of Chronic Kidney Disease (CKD) in people with Type 2 Diabetes Mellitus (T2DM) in the Autonomous Community (AC) of Aragon (Spain) and to detect whether or not there is under-registration in the patient's history. As a secundary objetive, it was proposed to study the most relevant demographic and clinical characteristics of people with CKD.
METHODS: Observational and retrospective real world data study of the population over 18 years of age with a diagnosis of T2DM, between January 2017 and December 2021. A descriptive analysis of qualitative and quantitative variables, and a comparison using the parametric Student's t-test or the non-parametric Mann-Whitney U-test between both groups was performed.
RESULTS: The prevalence of T2DM was 8.07 % and that of CKD 31.4 %, with an under-reporting of 47 %. The main risk factor associated with CKD was arterial hypertension (p<0.001), followed by dyslipidemia (p<0.001). The main treatment used for diabetes control was metformin, both in patients with and without CKD (p<0.001). A total of 56.81 % of people with T2DM and CKD did not undergo annual monitoring of their renal function (glomerular filtration rate) or determination of albuminuria.
CONCLUSIONS: The prevalence of CKD increases in patients with T2DM (31.4 %), and in almost half of patients the diagnosis is not registered (47 %). This under-reporting delays the implementation of measures needed to prevent CKD progression.
The sphincterotomy was performed through a new incision, guided by the surgeon's finger, as described by Boulos et al Boulos PB, Araujo JG. Adequate internal sphincterotomy for chronic anal fissure: subcutaneous or open technique? The British journal of surgery 1984;71:360-2.
The anatomy of the paranasal sinuses is important for many surgeon groups. The precise knowledge of such structures with variable anatomy will be important for the preservation of these structures and the management of complications in surgeries such as endoscopic sinus surgery and osteotomies involving the maxilla such as Le Fort osteotomies. The maxillomandibular complex is often affected by developmental problems and growth problems, and unilateral, bilateral, horizontal, vertical and / or transverse deficiencies are observed. Treatment of this complex is often performed by surgical intervention involving one or both jaws. In surgeries involving the maxilla, maxillary sinuses are affected by the surgery and affect the course of surgery. Paranasal sinuses are also very important structures for closely related endoscopic sinus surgeries. Detailed preoperative investigation is crucial for patient selection and hence desired outcome. Study was conducted in Ankara University Faculty of Dentistry with Ethical approval number:08/03. Computed tomography scans of 120 patients (59 maxillary deficiency patients and 61 healthy controls) were included in the study. CT scan indications for the group with maxillary deficiency was surgical preparation for Le Fort I osteotomy. The control group had no maxillary deficiency and CT images were obtained for several reasons such as temporomandibular disease, preparation for orthodontic treatment, obstructive sleep apnea and also paranasal sinus imaging Patients with a history of trauma in the midline skull base were excluded. Statistically significant results were obtained between groups for ethmoid and maxillary sinus volumes (left and right). Ethmoid and maxillary sinus volumes (left and right) were smaller in the Le Fort group. No statistically significant differences were present for sphenoid sinus volume of two groups and for the left and right maxillary sinus volumes in both groups.
Which breakfast has the most beneficial effect on blood glucose and insulin, blood hormones and blood pressure, egg or cereal breakfast? Over a seven week period the participant will take part in eating breakfast of either egg breakfast or cereal breakfast which will be monitored. Blood samples will be taken before participants eat and different times throughout until after Lunch on day 1 and day 7. Questionnaires will be given to determine satiety (feeling of fullness) and hunger before and after breakfast and lunch. After a two week period participants will return for another week of the same procedure and tests that was followed from Day 1 though day 7 listed. However, this time participants will be eating the second of the two breakfasts whichever one they did not have for the first test period.
It is hypothesized that initiation and propagation of atrial fibrillation (AF) is dependent, at least in part, on rapid atrial stimulation from focal sources. It is debated whether the mechanism of arrhythmogenesis at these foci is abnormal automaticity, triggered activity, microreentry or rotational reentry. However, after activation emerges from these "driver" sites, fibrillatory conduction ensues resulting in the disorganized conduction pattern of AF. Conventional mapping systems can either achieve high spatial resolution by sequential tachycardia beats following a fixed intra-atrial activation pattern (as in macro reentrant atrial flutter), or high temporal resolution with very low spatial resolution achieved through multielectrode basket catheters. Activation mapping in AF with commercially available mapping systems has been unsuccessful in identifying driver sites because atrial activation patterns change on a beat-to-beat basis precluding the use of sequential mapping approaches, and real-time mapping with basket electrodes lacks sufficient resolution to delineate the complex patterns of conduction. Electrographic Flow (EGF) mapping (AblaMap®, Ablacon, Inc, Wheat Ridge, CO) is a unique method to assess dominant patterns of intra-atrial conduction during ongoing atrial fibrillation and has been previously described. Recordings from a multielectrode basket catheter are analyzed for electrical activation vectors over sequential 2-second segments during a 60 second acquisition period. Patterns of reproducible vector activation are used to identify driver sources for the AF. Multiple sources are often identified in patients with persistent AF. It is anticipated that substrate modification of these source regions will eliminate the AF drivers and result in a favorable response to catheter ablation.

Participants undergoing elective catheter ablation of AF will be enrolled. During the elective catheter ablation and during ongoing AF, A 64-pole basket mapping catheter (FIRMap™, Abbott Laboratories, Abbott Park, IL) will be inserted into the right atrium, and electrical signals will be passively acquired. This is the only aspect of the procedure that will be research beyond standard of care. A 16-pole HD grid mapping catheter (Advisor™ HD Grid, Abbott Laboratories, Abbott Park, IL) will be inserted into the right atrium and high density electrogram signals will be recorded from each site for 2 minutes. At least 6 sites will be assessed. After transseptal catheterization, mapping of the left atrium will proceed in a similar fashion. Electrogram signals will be recorded in the electroanatomical mapping system as well as the 128-channel electrophysiology recording system. The collected electrogram data will be analyzed post procedure.
Prior to standard of care planned procedure, patients receive megestrol acetate PO BID for 21-35 days (up to and including the night before planned procedure) in the absence of disease progression or unacceptable toxicity. Patients also undergo biopsy on the day of planned procedure.
The invention discloses a traditional Chinese medicine composition for treating bacillary dysentery, and belongs to the traditional Chinese medicine field. The raw material medicine for producing the effective components of medical gruel for treating bacillary dysentery comprises the following components in percent by weight: purple garlic is 30 percent, pomegranate rind is 15 percent, dried ginger is 10 percent, red halloysite is 10 percent, and japonica rice is 100 percent. The peeled purple garlic, the pomegranate rind, the dried ginger and the red halloysite are put into water and boiled, and the medicinal solution is filtered out. Then the japonica rice is rinsed and added into the medicinal solution, and cooked into gruel. The gruel can be taken warmly with empty stomach in the morning and the evening everyday, 10 to 15 days are a course of treatment, and the second course of treatment is performed after 3 to 5 days. After the medicines are combined by the invention, the drug effect has a synergic action, and the chronic bacillary dysentery can be efficiently treated by keep taking the medicined gruel for treating bacillary dysentery.