anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine; oncology.SUBSTANCE: group of inventions relates to the field of medicine, namely to oncology; it is intended for the treatment of a patient with solid tumor. A method for the treatment of a patient with solid tumor includes i) systematic injection to a patient of liposomal irinotecan once every two weeks and ii) injection of poly(ADP-ribose)polymerase (hereinafter – PARP) inhibitor daily during from 3 to 10 days between sequential injections of liposomal irinotecan. PARP inhibitor is injected beginning after at least 2, 3, 4 or 5 days after the injection of liposomal irinotecan and ending at least before 1, 2, 3, 4 or 5 days till the next injection of liposomal irinotecan. In another option, a method for the treatment of a patient with solid tumor includes introduction to a patient of an antineoplastic therapy in 28-day treatment cycle. The antineoplastic therapy consists of: i) injection of liposomal irinotecan on 1 and 15 day of the treatment cycle and ii) injection of poly(ADP-ribose)polymerase (PARP) inhibitor during one or more days beginning at least after 3 days after the injection of liposomal irinotecan and ending at least before 1 day till the injection of additional liposomal irinotecan. In on more option, a method for the treatment of a patient with cancer and with tumor includes i) parenteral injection to a patient of effective amount of liposomal irinotecan and ii) injection to a patient of effective amount of poly(ADP-ribose)polymerase (PARP) inhibitor, where PARP inhibitor is injected to a patient after an effective interval for irinotecan removal from plasma. The effective interval for irinotecan removal from plasma is: a) from about 48 to about 120 hours and/or b) 2, 3, 4 or 5 fays.EFFECT: use of the group of inventions allows increasing the efficiency of the treatment of cancer in a patient.28 cl, 21 dwg, 16 tbl, 10 ex
Puncture will be performed on the posterior median line near the midpoint of the L3-4 Space of spinous process. The lumbar puncture needle will be inserted vertically along the axis of the anesthesia needle, or the tip of the needle will be tilted 15° in the sagittal direction toward the head, so that the needle path is parallel to the space of spinous process.
Onabotulinum toxin A. 200 units of Botox installed into the bladder by catheter.
The invention discloses a method for extracting active ingredient of root drug ingredients by using microwave radiation. The root drug ingredients yinpian is soaked in water which is 8 to 12 times more than the drug ingredients in quality; then the yinpian and the soak solution are irradiated by microwave, the microwave irradiance power density is controlled between 15W/g to 100W/g, and the microwave irradiance time is ranged from 3 minutes to 20 minutes. The microwave irradiance processing is performed under common pressure. The extracting rate of active ingredients can be raised by pouring out partial soak solution; the residual soak solution is irradiated by microwave; and at last, the soak solution poured out is mixed with the soak solution irradiated by microwave. By using the characteristics of the thermal effect and non-thermal effect of microwave technology, the leakage flow route of water and active ingredients in the vegetative material can be obviously improved, and the mass transfer in host material can be reinforced, thus significantly improving the extracting rate, and overcoming the problems that the traditional extraction process by backflow has long time and large solvent consumption. The method has no special requirements on the existing microwave facilities.
A method for administering solid water particles to prevent bacteria growth in living organisms utilizes a solid water particle (SWP) solution to attract and kill a bacterium through polarization. The method inhibits growth of a bacterium or an enveloped virus with an inorganic solution comprised substantially of SWP. The SWP kill the bacterium by providing a solution comprised substantially of SWP having inherent dipole characteristics that generate an electric field. The generated electric field attracts a bacterium to the SWP. Once engaged, the bacterium cannot move. The electric field also creates sufficient internal pressure in the bacterium, which bursts the cell walls of the bacterium, thereby killing bacterium. This mechanism also kills superbug, which are drug resistant bacteria. The method is also efficacious for killing enveloped viruses in the same manner. Further, administering the SWP solution into the mouth for a duration, helps reduce tooth pain and treat periodontal diseases.
Participants will receive standard pessary care, and those participants randomized to the experimental group will then be given a prescription for vaginal estradiol and instructed to apply it in the vagina nightly for two weeks and then twice weekly thereafter. Participation requires follow up visit 6 months from initial baseline visit. At this visit, participants are asked about vaginal bleeding, degree of bother due to vaginal discharge, and degree of pessary discomfort and a physical exam is performed.
Aging and age-related diseases are associated with cellular stress, metabolic imbalance, oxidative stress, and neuroinflammation, accompanied by cognitive impairment. Lifestyle factors such as diet, sleep fragmentation, and stress can potentiate damaging cellular cascades and lead to an acceleration of brain aging and cognitive impairment. High-fat diet (HFD) has been associated with obesity, metabolic disorders like diabetes, and cardiovascular disease. HFD also induces neuroinflammation, impairs learning and memory, and may increase anxiety-like behavior. Effects of a HFD may also vary between sexes. The interaction between Age- and Sex- and Diet-related changes in neuroinflammation and cognitive function is an important and poorly understood area of research. This study was designed to examine the effects of HFD on neuroinflammation, behavior, and neurodegeneration in mice in the context of aging or sex differences. In a series of studies, young (2-3 months) or old (12-13 months) C57BL/6J male mice or young male and female C57Bl/6J mice were fed either a standard diet (SD) or a HFD for 5-6 months. Behavior was assessed in Activity Chamber, Y-maze, Novel Place Recognition, Novel Object Recognition, Elevated Plus Maze, Open Field, Morris Water Maze, and Fear Conditioning. Post-mortem analyses assessed a panel of inflammatory markers in the plasma and hippocampus. Additionally, proteomic analysis of the hypothalamus, neurodegeneration, neuroinflammation in the locus coeruleus, and neuroinflammation in the hippocampus were assessed in a subset of young and aged male mice. We show that HFD increased body weight and decreased locomotor activity across groups compared to control mice fed a SD. HFD altered anxiety-related exploratory behavior. HFD impaired spatial learning and recall in young male mice and impaired recall in cued fear conditioning in young and aged male mice, with no effects on spatial learning or fear conditioning in young female mice. Effects of Age and Sex were observed on neuroinflammatory cytokines, with only limited effects of HFD. HFD had a more significant impact on systemic inflammation in plasma across age and sex. Aged male mice had induction of microglial immunoreactivity in both the locus coeruleus (LC) and hippocampus an effect that HFD exacerbated in the hippocampal CA1 region. Proteomic analysis of the hypothalamus revealed changes in pathways related to metabolism and neurodegeneration with both aging and HFD in male mice. Our findings suggest that HFD induces widespread systemic inflammation and limited neuroinflammation. In addition, HFD alters exploratory behavior in male and female mice, and impairs learning and memory in male mice. These results provide valuable insight into the impact of diet on cognition and aging pathophysiology.
In a new process for the prodn. of an aerosol compsn. contg. (1) a hydrophobic propellant, (2) at least one hydrophobic component which is soluble in the propellant, opt. (3) hydrophilic components and/or (4) solid, insoluble components, (A) the hydrophobic components are dissolved in the hydrophobic propellant before filling, and (B) the resulting soln. is compressed into a pressure container. Used in prodn. of aerosol compsns. such as aerosol permanent wave, fixative, dry shampoo or dry deodorant compsns., medicaments in aerosol form, door lock de-icer aerosols, over cleaner aerosols, and polishing and cleaning compsns. in aerosol form. Dissolution of the hydrophobic components in the propellant simplifies the filling procedure, and permits small amts. of hydrophobic components to be accurately measured.
BACKGROUND: Ultrasound energy can successfully treat fine lines and wrinkles, as well as lift the eyebrow and submentum. Ultrasound waves of high intensity induce thermal injury in the dermis with subsequent tissue remodeling.
OBJECTIVE: To examine the utility of a novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams to improve the clinical appearance of cellulite on the thighs and buttocks.
MATERIALS AND METHODS: A prospective, multicenter, clinical study investigated this novel ultrasound device using 2 treatments.
RESULTS: Sixty-five subjects completed both treatments. The mean age was 46 years, and 100% were women. Fitzpatrick skin types I to VI were represented. Assessments compared 3-month follow-up with baseline. Two blinded reviewers agreed in identifying pretreatment and post-treatment photographs for 89.2%. For Cellulite Severity Scale rating, there was significant improvement of 1.61 units ( p < .001). For cellulite Global Aesthetic Improvement Scale (GAIS), 89.2% had improvement, with a mean of 0.87 units ( p < .001). For Laxity Scale rating, there was significant improvement of 0.70 units ( p < .001). For skin laxity GAIS, 89.2% had improvement, with a mean of 0.76 units ( p < .001). No device-related adverse events occurred.
CONCLUSION: A novel ultrasound device that utilizes high-intensity, high-frequency, parallel ultrasound beams can safely and effectively improve the clinical appearance of cellulite on the thighs and buttocks.
PURPOSE:To obtain a crude drug from an optional part in an optional period on a factory production scale, by tissual cultivation of a plant of the genus Linum in an aritificial culture medium and collecting the crude drug of Linum usitatissimum from the resultant culture. CONSTITUTION:A tissual piece, preferably budding leaf, etc., of a plant of the genus Linum, e.g. Linum usitatissimum, etc., is cultivated in an artificial culture medium, e.g. at 15-30 deg.C and 3.5-8.5pH under dark or light condition. The resultant calli are then cultivated in a differentiation inducing culture medium to grow cupules, adventitious buds. etc. Components are then extracted therefrom to afford the aimed crude drug.
Globus pharyngeus or sensation may be defined as a feeling of something a lump in the throat without dysphagia. The study will assess the construct validity and reliability of the Turkish version of Laryngopharyngeal Measure of Perceived Sensation (T-LUMP) Questionnaire. The investigators developed the Turkish version of this questionnaire (T-LUMP), according to the cross-cultural adaptation guidelines. Two translators translated the LUMP into Turkish and a native English language speaker reverse-translated it into English. The back translation was sent to the original author for proofreading. The final version of the LUMP questionnaire consisted of 8 basic and understandable questions related with globus pharyngeus symptoms.
BACKGROUND: The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, and calcium signaling are regulated by MAMs, which are thought to be closely related to ischemic reperfusion injury (IRI). However, there exists a gap in systematic proteomic research addressing the relationship between these cellular processes.
METHODS: A 4D label free mass spectrometry-based proteomic analysis of mitochondria associated membranes (MAMs) from the human renal proximal tubular epithelial cell line (HK-2 cells) was conducted under both normal (N) and hypoxia/reperfusion (HR) conditions. Subsequent differential proteins analysis aimed to characterize disease-relevant signaling molecules. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was applied to total proteins and differentially expressed proteins, encompassing Biological Process (BP), Cell Component (CC), Molecular Function (MF), and KEGG pathways. Further, Protein-Protein Interaction Network (PPI) exploration was carried out, leading to the identification of hub genes from differentially expressed proteins. Notably, Mitofusion 2 (MFN2) and BCL2/Adenovirus E1B 19-kDa interacting protein 3(BNIP3) were identified and subsequently validated both in vitro and in vivo. Finally, the impact of MFN2 on MAMs during hypoxia/reoxygenation was explored through regulation of gene expression. Subsequently, a comparative proteomics analysis was conducted between OE-MFN2 and normal HK-2 cells, providing further insights into the underlying mechanisms.
RESULTS: A total of 4489 proteins were identified, with 3531 successfully quantified. GO/KEGG analysis revealed that MAM proteins were primarily associated with mitochondrial function and energy metabolism. Differential analysis between the two groups showed that 688 proteins in HR HK-2 cells exhibited significant changes in expression level with P-value < 0.05 and HR/N > 1.5 or HR/N < 0.66 set as the threshold criteria. Enrichment analysis of differentially expressed proteins unveiled biological processes such as mRNA splicing, apoptosis regulation, and cell division, while molecular functions were predominantly associated with energy metabolic activity. These proteins play key roles in the cellular responses during HR, offering insights into the IRI mechanisms and potential therapeutic targets. The validation of hub genes MFN2 and BNIP3 both in vitro and vivo was consistent with the proteomic findings. MFN2 demonstrated a protective role in maintaining the integrity of mitochondria associated membranes (MAMs) and mitigating mitochondrial damage following hypoxia/reoxygenation injury, this protective effect may be associated with the activation of the PI3K/AKT pathway.
CONCLUSIONS: The proteins located in mitochondria associated membranes (MAMs) are implicated in crucial roles during renal ischemic reperfusion injury (IRI), with MFN2 playing a pivotal regulatory role in this context.
Chemsex refers to the use of psychoactive substances with sex. We carried out a systematic scoping review of methodological characteristics of chemsex research among men who have sex with men (MSM), published between 2010 and 2020. For inclusion, chemsex had to be the main focus, and studies had to specify GHB/GBL, stimulant (amphetamine, crystal meth, ecstasy/MDMA, cathinones, cocaine) and/or ketamine use with sex as a variable. From 7055 titles/abstracts, 108 studies were included, mostly cross-sectional, and from Western countries. About one-third of studies recruited exclusively from clinical settings. A majority of these recruited from sexually transmitted infection (STI) clinics. The included quantitative studies analyzed possible associations between chemsex and STI health (40%), mental health (15%), drug health (12%), sexological health (10%), and post-diagnostic HIV health (7%). Most studies included GHB/GBL and crystal meth in their operationalization of chemsex. Definitions and operationalizations of chemsex vary greatly in the literature, and researchers of chemsex among MSM should consider ways in which this variation impacts the validity of their results. More studies are needed among MSM in non-high income and non-Western countries, and examination of possible links between chemsex and post-diagnostic HIV health, sexological health, and mental health.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a currative treatment modality for diffuse large B-cell lymphoma (DLBCL) because of the intrinsic graft-versus-lymphoma effect. However, limited information is available regarding which patients with relapsed or refractory DLBCL are likely to benefit from allo-HSCT. We retrospectively analyzed data from 1268 DLBCL patients who received allo-HSCT. The overall survival and progression-free survival (PFS) rates were 30.3% and 21.6% at 3 years, respectively. Multivariate analysis revealed that stable or progressive disease at transplantation, male patient, poorer performance status at transplantation, and shorter intervals from previous transplantation were associated independently with a lower PFS. Four prognostic factors were used to construct a prognostic index for PFS, predicting 3-year PFS of 55.4%, 43.7%, 20.4% and 6.6%, respectively. The prognostic model predicted relapse rates following allo-HSCT accordingly (P < 0.0001), whereas did not predict transplantation-related mortality (P = 0.249). The prognostic index can identify a subgroup of DLBCL patients who benefit from allo-HSCT and it is worthwhile to evaluate whether this model is also applicable to patients undergoing allo-HSCT in cases of relapse after chimeric antigen receptor engineered T-cell therapy, although the application of allo-HSCT has been declining with the increase of novel immunotherapies.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, oncology, and concerns combination treatment of stage IIIA-IIIB locally advanced non-small-cell lung cancer (LA NSCLC). A method involves preoperative chemotherapy according to the schedule paclitaxel 175 mg/m2 intravenously drop-by-drop on the 1st day and carboplatin AUC 6 intravenously drop-by-drop on the 1st day, 2 courses every 3 weeks, then a radical surgery combined with intraoperative radiation therapy on regional lymphatic cancer spreads in a single dose 15 Gy with underlying cisplatin radiosensitisation. The surgery involves combined operations with resection of a chest wall, and/or a diaphragm, and/or an oesophagus, and/or great vessels, and/or a pericardium, and/or auricles with the resected regions to be covered by the intraoperative radiation. ^ EFFECT: method provides improved survival rate in the patients suffering stage IIIA-IIIB LA NSCLC ensured by higher respectability of a tumour process, reduced rate of local recurrences and remote metastases. ^ 2 ex
Amadori or Heyns compounds are prepared by condensing an a -amino acid with a reducing monosaccharide or oligo saccharide to form an N-glycoside which is then rearranged by the addition of a proton donor.  (Amadori compounds are described in "Name Index of Organic Reactions," J. E. Gowan & T. S. Wheeler, Longmans, Green & Co. Ltd., 1960, and Heyns compounds are described in Chemische Berichte, 1953, 86, 1453).  Mixtures of the amino acids and mixtures of the sugars may be used in the preparations.  The amino acids are preferably used in the form of alkali metal salts. In Examples, monosodium L-glutamate is reacted with D-glucose, and mono-sodium L-aspartate is reacted with D-ribose by heating in aqueous solution; in both cases the free carboxylic acid group of the amino acid salt serves as the proton donor for the rearrangement of the N-glycoside formed.  The rearranged products are used in moisturizing compositions for pharmaceutical products (see Division A5).ALSO:Synthetic moisturizing compositions for use in cosmetic and pharmaceutical products comprise a mixture of (a) and Amadori or Heyns compound formed by rearranging, by the addition of a proton donor, the N-glycoside formed in the condensation of an a -amino acid (several specified) with a reducing monosaccharide or oligosaccharide (several specified) and (b) from 0.1 to 90% by weight of the mixture of aspartic acid.  The mixture preferably also contains urea in a proportion of from 0.1 to 90% by weight of the mixture.  The composition preferably has a pH between 3 and 9. Other substances which may be included in the compositions are amino acids such as glycine, threonine, alanine, tyrosine, valine, leucine, phenylalanine, proline, critrulline, ortithine, histidine, lysine, arginine, glutamic acid and serine; pyrrolidoncarbonic acid; ammonia; uric acid; ribose; glucosamine; creatinine; salts such as sodium lactate, sodium citrate, sodium chloride, calcium chloride, potassium chloride and magnesium hydrogen phosphate.  The moisturizing compositions may be incorporated into products such as after-shave lotions, lipsticks, ointments, bath oils and sun tan lotions.
Between October 1-7, 2020, women from across the US were recruited by Rae Wellness to participate in a 60-day in-home use test (IHUT) of various Cannabidiol (CBD) products. The inclusion criteria were: women; between the ages of 24-44; reported symptoms associated with at least 4 out of 6 health issues (stress; anxiety; pain; sleep issues; digestive issues; low libido). Individuals were excluded if they were pregnant or breastfeeding. 1,350 women were randomly selected to participate in the study. The participants were randomized to one of 9 groups in the IHUT (150 in each group): 8 groups received one of 8 different CBD products in the mail, and one group served as the control and did not consume any CBD product. The CBD products varied by method of delivery (oil or capsule), concentration of Tetrahydrocannabinol (THC; less than 0.3% THC or 0% THC), and dosage of CBD (15, 20, 25 and 30 mg). Participants were asked to use the product once daily every day for 60 consecutive days, and to complete a health questionnaire online on 3 occasions: before initiating the product (baseline), 30 days after initiating the product, and 60 days after initiating the product. Those in the control group were also asked to complete the health questionnaire at each time point but did not receive nor consume any CBD product. The health questionnaire assessed anxiety, physical health, digestive health, sleep patterns, general wellness and sexual satisfaction using questions drawn from validated health indices.
This invention provides a health food capable of improving the sleeping quality and the metabolic function. The health food is mainly in the form of a capsule and includes a capsule body. The weight ratios of its main components are 44.93 milligrams (±25%) of magnesium (Mg), 3.8 milligrams (±25%) of zinc (Zn), 40 micrograms (±25%) of selenium (Se) and 40 micrograms (±25%) of chromium (Cr). Magnesium (Mg) can improve the prevention ability of the cardiovascular disease. Zinc (Zn) can increase the energy of mitochondria and enhance the metabolic function. Selenium (Se) can effectively reduce the risk of cancer and inhibit the infection of RNA virus. Chromium (Cr) can reduce the risk of type 2 diabetes. The combination of the above components can mainly improve the sleeping quality, reduce the sleeping demand, and increase the resistance of a human body to diseases.