anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Acetaminophen (ACE) is a widely used analgesic and antipyretic drug with various applications, from pain relief to fever reduction. Recent studies have reported equivocal effects of habitual ACE intake on exercise performance, muscle growth, and risks to bone health. Thus, this study aimed to assess the impact of a 6-week, low-dose ACE regimen on muscle and bone adaptations in exercising and non-exercising rats. Nine-week-old Wistar rats (n = 40) were randomized to an exercise or control (no exercise) condition with ACE or without (placebo). For the exercise condition, rats ran 5 days per week for 6 weeks at a 5% incline for 2 min at 15 cm/s, 2 min at 20 cm/s, and 26 min at 25 cm/s. A human equivalent dose of ACE was administered (379 mg/kg body weight) in drinking water and adjusted each week based on body weight. Food, water intake, and body weight were measured daily. At the beginning of week 6, animals in the exercise group completed a maximal treadmill test. At the end of week 6, rats were euthanized, and muscle cross-sectional area (CSA), fiber type, and signaling pathways were measured. Additionally, three-point bending and microcomputer tomography were measured in the femur. Follow-up experiments in human primary muscle cells were used to explore supra-physiological effects of ACE. Data were analyzed using a two-way ANOVA for treatment (ACE or placebo) and condition (exercise or non-exercise) for all animal outcomes. Data for cell culture experiments were analyzed via ANOVA. If omnibus significance was found in either ANOVA, a post hoc analysis was completed, and a Tukey's adjustment was used. ACE did not alter body weight, water intake, food intake, or treadmill performance (p > .05). There was a treatment-by-condition effect for Young's Modulus where placebo exercise was significantly lower than placebo control (p < .05). There was no treatment by condition effects for microCT measures, muscle CSA, fiber type, or mRNA expression. Phosphorylated-AMPK was significantly increased with exercise (p < .05) and this was attenuated with ACE treatment. Furthermore, phospho-4EBP1 was depressed in the exercise group compared to the control (p < .05) and increased in the ACE control and ACE exercise group compared to placebo exercise (p < .05). A low dose of ACE did not influence chronic musculoskeletal adaptations in exercising rodents but acutely attenuated AMPK phosphorylation and 4EBP1 dephosphorylation post-exercise.
Randomization to receive ketamine as first post-operative sedative in the Neuroscience Intensive Care unit. This group will cross-over to "other sedation" after 6 hours, then alternate every 6 hours between these groups during the entirety of invasive neuromonitoring.
Vitamin A and D concentrates are obtained from fish oils by countercurrent extraction of the oil with a polar organic solvent which is a partial solvent for the oil and is relatively insoluble in naphtha, in a ratio of about 3-30 parts of solvent per part of oil, at such a temperature that about 2-30 per cent of the oil enters the solvent phase, and subsequently washing the solvent extract with naphtha.  The vitamins and antioxidants in the oil which are extracted by the polar solvent are thus transferred to the naphtha solution from which they are recovered by distillation.  Suitable polar solvents are chosen from alcohols, esters, carboxylic acids, nitriles, carbamic acid esters, organic carbonates and phosphates, nitro compounds and amides.  Suitably the extraction is carried out in a vertical column.  The glyceride oil is introduced at a point midway up the column and the polar solvent is introduced near the top.  Raffinate oil is taken off at the top of the column and after being stripped of solvent may be passed to storage or transferred to another column for further extraction.  The vitamin enriched solvent fraction is taken off at the base of the column and is transferred to a further column where it is contacted with naphtha.  The naphtha phase is drawn off and the solvent removed by distillation, leaving the vitamin concentrate.  Modifications of the process allow the extract and raffinate fractions to be recycled to give more thorough extraction of the oil.  In examples (1), (2) and (3) dogfish liver oil containing 17,200 units of vitamin A per gm. is extracted with furfural saturated with naphtha to give a raffinate containing 3,440 units of vitamin A per gm. and a solvent phase which is contacted with naphtha to give on distillation an extract with a potency of 92,800 units per gm.; (4) sardine oil is extracted by the method of (1); (5) dogfish liver oil is extracted with methyl acetoacetate as in (1) and (6) dogfish liver oil is extracted with the monomethyl ether of ethylene glycol as in (1).  Specifications 475,070 and 515,468 are referred to.
Active treatment group will receive an occlusal splint adjusted to the appropriate therapeutic height (based on an initial fitting). Participants will be instructed to wear the orthotic 24/7 (or as close as possible) for the duration of the study.
The present invention relates to a kind of preparation methods of oral solution that treating infantile cough, include the following steps：A. turtle shell is ground into fine powder, decoction and filters, and collects filtrate；B. RADIX ACONITI LATERALIS PREPARATA and honey-fried licorice root are decocted and are filtered, and collect filtrate；C. Rhizoma Atractylodis Macrocephalae, dried orange peel, sweet wormwood, cassia twig, rhizoma zingiberis, tussilago and aster carry out steam distillation, collect volatile oil, decocting liquid filtering, and the dregs of a decoction filter after decocting, merging filtrate；D. ginseng, Poria cocos, the membrane of a chicken's gizzard, Rheum palmatum (processed with wine), the root bark of Chinese wolf-berry, Radix Glehniae, Radix Ophiopogonis, Snakegourd Fruit, the root bark of white mulberry, arisaema cum bile, Radix Astragali and fruit of Chinese wolfberry refluxing extraction, filtering, filtrate decompression are concentrated into no alcohol taste, filter；Filtrate concentration stands, centrifugation, refrigeration, filters, and collects filtrate；E. filtrate obtained by step D is merged with filtrate obtained by filtrate obtained by filtrate, step B obtained by step A and step C, volatile oil, cosolvent, corrigent and preservative obtained by step C is then added, add water mixing, filtering, sterilizing.Oral solution safety made from this method is good, and absorption is very fast, good in taste, bioavilability is high.
The invention belongs to the technical field of biology, and particularly relates to a human staphylococcus and application thereof in preparing a medicament for inhibiting pathogen infection, resisting EB virus infection and regulating mucosal immune response. The human staphylococcus is named as human staphylococcus (Staphylococcus hominis) CT1 and is preserved in the Guangdong province microorganism strain collection center, address: 30, guangzhou city martyr, highway 100, highway 5, guangdong university, proc. Natl. Acad. Microorganism, accession number GDMCC No:64349 the preservation time is 2024, 1 month and 31 days. The human staphylococcus of the invention is derived from the nasopharynx of healthy people, has the activities of inhibiting pathogen infection, resisting EB virus infection and regulating mucosal immune response, can obviously assist epithelial cells to resist EB virus infection, inhibit various pathogenic bacteria, and is hopeful to be developed into a medicament or a probiotic preparation for resisting pathogen infection and regulating mucosal immunity.
BACKGROUND: Patients presenting to the emergency department with acute vertigo pose a diagnostic challenge. While 'benign' peripheral vestibulopathy is the most common cause, the possibility of a posterior circulation stroke is paradoxically the most feared and missed diagnosis in the emergency department.
OBJECTIVES: This review will attempt to cover the significant advances in the ability to diagnose acute vertigo that have occurred in the last two decades. The review discusses the role of neurological examinations, imaging and specific oculomotor examinations. The review then discusses the relative attributes of the Head Impulse-Nystagmus-Test of Skew plus hearing ('HINTS+') examination, the timing, triggers and targeted bedside eye examinations ('TiTrATE'), the associated symptoms, timing and triggers, examination signs and testing ('ATTEST') algorithm, and the spontaneous nystagmus, direction, head impulse testing and standing ('STANDING') algorithm. The most recent technological advancements in video-oculography guided care are discussed, as well as other potential advances for clinicians to look out for.
Oral or intranasal antihistamines is the first line treatment for allergic rhinitis. Cetirizine is a second-generation selective antihistamine widely used in an oral formulation for the treatment of allergic rhinitis. Local administration of cetirizine has been shown to reduce symptoms after allergen challenge, and has the potential to shorten the time to onset and decrease systemic side effects. However, local irritation and nasal burning/pain has been reported after nasal administration. For the compliance of the patients taking a nasal spray, the taste and tolerance of the product is of particular importance. NLA Nasal Spray contains cetirizine in a liposomal formulation aiming to improve the tolerability. The present study aims to compare the NLA Nasal Spray with cetirizine in an aqueous formulation and placebo with regard to taste perversion and local tolerance. This will be investigated off-season in patients with seasonal allergic rhinitis after provocation with allergen.
PROBLEM TO BE SOLVED: To prepare a controlled release base and a controlled release film- forming agent both capable of releasing drug at a stable releasing speed for a releasing period by irradiating ultraviolet rays to of a specific polyester, its copolymer or their blended polymer. SOLUTION: This controlled release base and the controlled release film- forming agent are prepared by irradiating ultraviolet rays to a polyester having 300-50,000 (pref. 900-30,000) weight average molecular weight and mainly comprising (usually >=70 mol%, pref. >= 80 mol%, more pref. >=90 mol%) aliphatic structural units, its copolymer or their blended polymer. The polyester cited is (A) the one mainly comprising aliphatic hydroxycarboxylic acid units, (B) the one mainly comprising aliphatic hydroxycarboxylic acid units, aliphatic polybasic carboxylic acid units and aliphatic polyhydric alcohol units, or the like.
Circular RNAs (circRNAs) are covalently closed noncoding RNA molecules that play multiple roles in tumorigenesis and metastasis. Ferroptosis is an iron-dependent, regulated form of cell death and has emerged as a promising target for cancer treatment. However, whether and how circRNAs regulate ferroptotic cell death in colorectal cancer (CRC) remains largely unknown. Three circRNA microarrays were used to screen differentially expressed circRNAs in CRC tissues. A series of functional experiments were conducted to investigate the effects of circRNA on CRC cell proliferation, migration and ferroptosis. We found that hsa_circ_0058495 (circRHBDD1), a novel circRNA, was significantly upregulated in colorectal cancer tissues and cells. The expression levels of circRHBDD1 in serum samples were strongly associated with the advancement of CRC. Silencing of circRHBDD1 remarkably suppressed the proliferation and migration of CRC cells in vitro. Moreover, the depletion of circRHBDD1 notably increased ferroptotic cell death and enhanced RSL3-induced ferroptosis in CRC cells. Mechanistically, circRHBDD1 upregulated the expression of stearoyl-CoA desaturase (SCD), a ferroptosis suppressor mediating lipid remodelling, by enhancing the ELAVL1/SCD mRNA interaction. Finally, circRHBDD1 knockdown repressed the tumorigenesis and ferroptosis of CRC cells in vivo. In conclusion, circRHBDD1 facilitates tumour progression and obstructs ferroptosis in CRC by regulating SCD expression in an ELAVL1-dependent manner.
Biliary atresia (BA) is the most common cause of chronic cholestasis in neonates and accounts for at least 50% of pediatric liver transplants. The incidence of BA is estimated to range from 1:5000 to 1:19000 live births. If the operation is not performed, all patients will die due to complications of liver cirrhosis. Recently, mesenchymal stem cell (MSC) transplantation has been found to be a promising treatment for liver cirrhosis in adults. Stem cell transplantation derived from bone marrow has also been successfully applied to children with BA. The aim of this study is to demonstrate the efficacy of Umbilical Cord-Derived Mesenchymal Stem Cell (UC-MSC) therapy in BA by planning a multicentric randomized controlled trial.
A redirected Treg cell is endowed with specificity toward a selected target antigen or ligand. The cell contains a chimeric receptor polypeptide that is expressed in a single, continuous chain, with an extracellular recognition region displayed on the surface of the cell, a transmembrane region and an intracellular signaling region. The extracellular recognition region is specific for the selected target antigen or ligand. The intracellular signaling region includes a combination of T-cell signaling polypeptide moieties, which combination, upon binding of the extracellular recognition region to the selected target antigen or ligand, triggers activation of the redirected Treg cells to cause suppression of T-cell mediated immunity. Such redirected Treg cells may be used to suppress undesired activity of T effector cells thereby mediating an immune or inflammatory response. They are particularly useful in treating T effector cell-mediated diseases, such as inflammatory bowel disease, transplant rejection and GVH disease.
The present invention relates to a gynecological convalescence powder which belongs to an oral traditional Chinese medicine powder for treating various gynecological diseases. The prescription of the gynecological convalescence powder is composed of angelica, white peony alba, hemlock parsley, peach seed, safflower, nutgrass galingale rhizome, phellodendron bark, lightyellow sophora root, common cephalanoplos herb, plantain seed, gordon euryale seed, stir-baked purple Haricot, stir-baked largehead atractylodes rhizome, calcined oyster shell and turtle shell. The preparation method for the gynecological convalescence powder comprises: precisely separating each medicine; using the medicines according to the weight ratio of the prescription; processing, pulverizing and sieving the medicines to be bagged according to the dosage of each medicine. Each bag is 5 grams heavy. The present invention has the effects of nourishing blood, regulating menstruation, dispelling stasis, alleviating pain, drying dampness and checking vaginal discharge and is used for menoxenia, dysmenorrhoea, downward flows of damp-heat, yellow and thick vaginal discharge, vaginitis, endometritis, annexitis, cystis, dropsy, enclosed masses, pelvic inflammatory diseases, etc. The cure rate reaches 94%; the gynecological convalescence powder can treat both manifestations and root cause of diseases, thereby having remote possibility of relapse after cure.
BACKGROUND: Integrating sexually transmitted infection (STI) and preexposure prophylaxis (PrEP) care may optimize sexual and reproductive health.
METHODS: We nested an STI substudy within a human immunodeficiency virus (HIV) prevention cohort (parent study) of 18- to 35-year-old women from South Africa, planning pregnancy with a partner with HIV or of unknown serostatus. Parent-study women completed annual surveys regarding HIV-risk perceptions and were offered oral PrEP. Preexposure prophylaxis initiators completed quarterly plasma tenofovir (TFV) testing. Substudy women completed STI screening at enrollment, 6 months, onset of pregnancy, and in the third trimester via examination, vaginal swabs tested via PCR for Chlamydia trachomatis , Neisseria gonorrhoeae , Trichomonas vaginalis , Mycoplasma genitalium , and blood tested for Treponema pallidum . Follow-up was 6 months. Women with STIs were treated, offered partner notification (PN) cards, and surveyed regarding PN practices. We describe STI prevalence and incidence, and model factors associated with prevalent infection. Sexually transmitted infection substudy and parent study-only participants were matched on age and number of days on study to assess HIV-risk perception scores between the 2 groups and the proportion with detectable TFV.
RESULTS: Among 50 substudy participants, 15 (30%) had prevalent STI. All 13 completing follow-up reported PN. Most did not prefer assisted PN. Mean HIV risk perception scores and proportion with detected plasma TFV were similar across groups.
CONCLUSIONS: High STI prevalence supports the importance of laboratory screening to optimize sexual health for women planning pregnancy. Rates of self-reported PN are reassuring; low interest in assisted PN suggests the need for alternative approaches. Enhanced STI care did not affect HIV-risk perception or PrEP adherence, however both were relatively high in this cohort.
A group of ten (expected sample size) severe-to-profound hearing-impaired patients who have a past and/or present experience of more than 6 months with remote microphone systems. These patients are expected to be aware of the drawbacks of the current remote microphone technology with respect to sound localization, auditory distance estimation, and audio-visual fusion.
This study aims to recruit early and middle-stage Alzheimer patients aged between 60 and 75, along with age and gender-matched healthy older adults. Two different Alzheimer groups will be created: one group will utilize a 40 Hz sensory entrainment-integrated cognitive game kit at home, while the other group will not receive any treatment. The treatment group will comprise 10 Alzheimer patients who will engage with the 40 Hz sensory entrainment-integrated cognitive game kit for 1 hour a day, at least five days a week, for three months. Comprehensive neuropsychological assessments and electroencephalography (EEG) recordings will be conducted in the laboratory on the first day, followed by mobile EEG recordings at home at the end of the first and second months. After three months of using the sensory entrainment/cognitive game kit, the participants will again undergo neuropsychological assessment and EEG recording in the laboratory. The second Alzheimer group (n=10) will not be administered any treatment and will undergo the same assessment protocol as the treatment group. Furthermore, in addition to these two groups, a healthy older adult group (n=10) will also be included in the study, with assessments scheduled only on the first day and at the end of the third month.
The invention relates the preparing method for stopping smoking drug with anisodamine. The nicotine reacts with acetylcholine to produce specificity association. The more the nicotine is, the more the acetylcholine is. The anisodamine can effectively oppose the acetylcholine. The anisodamine can also remove free radical, protect cell, accelerate microcirculation flow ratio, and protect body. 5-50mg anisodamine can be mixed with 5% dextrose or 5% dextrose salt solution or 10% dextrose to intravenous inject or intramuscular inject or oral administration. One course of treatment is 10-14 days.
Patients receive placebo PO QD for 12 weeks in the absence of unacceptable toxicity. Patients undergo the collection of blood, nasal epithelial cell, and buccal cell samples throughout the study.
A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.
The present invention relates to a method for treating hypertension diseases, particularly to a method for externally treating internal disease hypertension by using traditional Chinese medicine. The present invention is characterized in that a method which causes the nose to generate watery nasal discharge and discharge wetness is adopted. In the method for causing the nose to generate the watery nasal discharge, a traditional Chinese medicine preparation enters through a nasal cavity to achieve the purposes of discharge of nasal damp pathogen, long-acting pressure reduction and pressure stabilization. The traditional Chinese medicine preparation comprises the ingredients of 2 to 46% of traditional Chinese medicine causing vomiting and 54 to 98% of traditional Chinese medicine for removing dampness, or the traditional Chinese medicine preparation comprises the ingredients of 1 to 32% of the traditional Chinese medicine for causing the vomiting, 14 to 32% of the traditional Chinese medicine removing the dampness and 50 to 75% of traditional Chinese medicine for reducing pressure. The traditional Chinese medicine preparation is powder can also be paste or liquor. At the time of treatment, the traditional Chinese medicine preparation is applied by nasal rating (nasal feeding) and simultaneously, the traditional Chinese medicine massage liquor is used for achieving the purposes of guiding yin to move downward, reducing pressure, stabilizing pressure and treating internal diseases externally by medicine administration on the zusanli acupoints and the yongquan acupoints on both sides for massage. The present invention has the advantages of obvious therapeutic effect and little side effect. The present invention can enable patients with hypertension diseases to be thoroughly cured.
AIMS: Mucinous ovarian carcinoma (MOC) is a rare ovarian cancer histotype with generally good prognosis when diagnosed at an early stage. However, MOC with the infiltrative pattern of invasion has a worse prognosis, although to date studies have not been large enough to control for covariables. Data on reproducibility of classifying the invasion pattern are limited, as are molecular correlates for infiltrative invasion. We hypothesized that the invasion pattern would be associated with an aberrant tumour microenvironment.
METHODS AND RESULTS: Four subspecialty pathologists assessed interobserver reproducibility of the pattern of invasion in 134 MOC. Immunohistochemistry on fibroblast activation protein (FAP) and THBS2 was performed on 98 cases. Association with survival was tested using Cox regression. The average interobserver agreement for the infiltrative pattern was moderate (kappa 0.60, agreement 86.3%). After reproducibility review, 24/134 MOC (18%) were determined to have the infiltrative pattern and this was associated with a higher risk of death, independent of FIGO stage, grade, and patient age in a time-dependent manner (hazard ratio [HR] = 10.2, 95% confidence interval [CI] 3.0-34.5). High stromal expression of FAP and THBS2 was more common in infiltrative MOC (FAP: 60%, THBS2: 58%, both P < 0.001) and associated with survival (multivariate HR for FAP: 1.5 [95% CI 1.1-2.1] and THBS2: 1.91 [95% CI 1.1-3.2]).
CONCLUSIONS: The pattern of invasion should be included in reporting for MOC due to the strong prognostic implications. We highlight the histological features that should be considered to improve reproducibility. FAP and THBS2 are associated with infiltrative invasion in MOC.