anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Washing-agents, suitable for use in the cleaning of textiles and in the preparation of tooth pastes and hair washes, are made by rendering neutral or acid, by means of a compound of acid reaction, a water-soluble salt of an aliphatic carboxylic acid containing an aliphatic radical of high molecular weight which is linked to the carboxyl group through at least one nitrogen atom, but not through an oxygen atom.  Specified salts are the alkali salts of octadecylenylaminoacetic acid, of oleyl sarcoside, and of coconut fatty acid sarcoside, and specified compounds of acid reaction are sodium bisulphite, sodium bisulphate, and boric, citric, tartaric and oxalic acids.  According to examples: (1) a liquid hair wash contains water, citric acid and the sodium salt of coconut oil fatty acid sarcoside; (2) a preparation for removing copying ink stains contains water, isopropyl-alcohol, citric acid and the sodium salt of coconut fatty acid sarcoside; (3) a hair wash powder contains sodium bisulphate, sodium chloride and the sodium salt of coconut oil fatty acid sarcoside; (4) a hair wash contains tartaric acid and the sodium salt of coconut oil fatty acid sarcoside.  According to the Specification as open to inspection under Sect. 91 the sodium salt of dodecylamino-acetic acid, the reaction product of octadecenylmethylamine on citric acid, and water-soluble salts of aliphatic carboxylic acids of high molecular weight, in which there is at least one nitrogen atom between the carboxyl group and the aliphatic radical may be used, but this subject-matter does not appear in the Specification as accepted.ALSO:Washing agents, suitable for use in the cleaning of textiles and in the preparation of tooth pastes and hair washes, are made by rendering neutral or acid, by means of a compound of acid reaction, a water-soluble salt of an aliphatic carboxylic acid containing an aliphatic radical of high molecular weight which is linked to the carboxyl group through at least one nitrogen atom, but not through an oxygen atom.  Specified salts are the alkali salts of octadecyl-enylamino-acetic acid, of oleyl sarcoside, and of coconut fatty acid sarcoside, and specified compounds of acid reaction are sodium bisulphite, sodium bisulphate, and boric, citric, tartaric and oxalic acids.  According to examples: (1) a liquid hair wash contains water, citric acid and the sodium salt of coconut oil fatty acid sarcoside; (2) a hair wash powder contains sodium bisulphate, sodium chloride and the sodium salt of coconut oil fatty acid sarcoside; (3) a hair wash contains tartaric acid and the sodium salt of coconut oil fatty acid sarcoside. According to the Specification as open to inspection under Sect. 91, the sodium salt of dodecylamino-acetic acid, the reaction product of octadecenylmethylamine on citric acid, and water-soluble salts of aliphatic carboxylic acids of high molecular weight, in which there is at least one nitrogen atom between the carboxyl group and the aliphatic radical may be used, but this subject-matter does not appear in the Specification as accepted.
BACKGROUND: Cardiovascular involvement in pediatric patients with connective tissue disease (CTD) is life-threatening, with aortic root dilatation being the most prevalent cardiovascular abnormality. We attempted to determine long-term outcomes of valve-sparing root replacement (VSRR) in this group, including cardiovascular reoperations for aortic aneurysm and dissection.
METHODS: We conducted a retrospective analysis of pediatric patients with CTD who received VSRR in a single center from 2002 to 2021. The primary end point was a composite event of all-cause death and cardiovascular reoperations. The median follow-up duration was 8.3 years, with a maximum of 20.7 years.
RESULTS: The median age of 24 pediatric patients who had VSRR was 14.4 years. Marfan syndrome and Loeys-Dietz syndrome affected 19 (79.2%) and 5 (20.8%) patients, respectively. There was no early death. The 15-year survival rate was 91.7%. At 10 years after VSRR, the cumulative incidence of reoperation for aortic regurgitation was 15.6%, and for aortic aneurysm or dissection, it was 29.1%. The 10-year rate of freedom from the primary end point was 53.1%. The Cox multivariable analysis revealed younger age at surgery (hazard ratio, 1.279; 95% confidence interval, 1.086-1.505; P = .003) and VSRR before 13 years of age (hazard ratio, 5.005; 95% confidence interval, 1.146-21.850; P = .032) as independent prognostic factors for the primary endpoint.
CONCLUSIONS: VSRR for aortic root dilatation in pediatric patients with CTD demonstrated good long-term survival and low reoperation rates for aortic regurgitation. However, several patients developed later aortic aneurysm or dissection, and careful surveillance may be required, particularly in those who received VSRR at younger age.
A wearable device (102) for estimating traditional medicine system parameters is disclosed. The wearable device (102) includes light sources, configured to stimulate skin of a patient through light rays. The wearable device (102) includes sensors (104), configured to capture patient health parameters. The plurality of subsystems includes a medical input data collection subsystem (112) configured to collect patient information, blood pulse parameters and the captured patient health parameters. The plurality of subsystems includes a health status computation subsystem (114), configured to apply the collected patient information the captured one or more patient health parameters and the blood pulse parameters onto trained machine learning model and estimate real time set of traditional medicine system parameters. The plurality of subsystems also includes a disease identification subsystem (116), configured to compare the real time set of traditional medicine system parameters with pre-stored traditional medicine system parameters, identify a disease and give recommendations.
Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution s comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride. A typical electrolyzed solution of the present invention has a pH within the range of about 2 to about 5, an oxidation reduction potential within the range of about +600 mV to about + 1200 mV, and hypohalous acid concentration in the range of about 10 ppm to about 200 ppm. The solution has bactericidal, fungicidal, and sporicidal properties. The composition of the invention is nontoxic and has antibacterial properties, and is useful in any application in which antimicrobial properties are desirable.
A virtual file cabinet system for organizing and providing a central repository for personal information is provided. Information is maintained in the virtual file cabinet according to various categories. Information that is particular to individual users of the virtual file cabinet is maintained within each category of information. Access to information maintained in the virtual file cabinet may be had by the user with whom such information is associated, or by authorized third parties. Information maintained in the virtual file cabinet is collected through forms, and through direct deposit of information by service providers and others generating the information. Resources, arranged according to categories of information to which they generally pertain, are available to users through the virtual file cabinet. Reports containing information collected through forms or otherwise, and that may contain information generated in connection with the application of information to resources, may be generated. The virtual file cabinet allows for the convenient retrieval and storage of personal information in a secure, centrally accessible site.
Survivors of NPC, diagnosed under 21 years of age, between 1990 and 2030. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, for an increased risk of late-occurring events associated with excess mortality and morbidity.
After acute coronary syndrome (ACS), it is recommended to propose a cardiac rehabilitation (CR) program in order to reduce the risk of recidive, to improve the quality of life and to reduce the risk of disabilities. Traditional CR which is most of the time center-based, is underutilized with less than 30% of patients addressed en France. Therefore, Télé-Cardiac Rehabilitation (Télé-RCV) has been developped progressively since the eighties showing comparable efficacity compared with CR concerning physical fitness. The investigative team, had previously published results showing that telephone support guided by accelerometers could improve physical activity. However, In France, device allowing telemonitoring online of heart rate are not available. Moreover, the investigators have not yet developped remote therapeutic education which is proposed in CR programs. Thus, the present study planned to develop and evaluate aTele-RCV solution aimed to monitor exercise training at home and to educate remotely patient after ACS.

The device is an association of a heart rate monitor, a blood pressure testing, a balance linked with a full web secured application connecting patient and caregivers. In the intervention group, Tele-RCV is proposed during 20 sessions containing 2h of exercise training combined with 6h of therapeutic tele-education. In the control group, CR is proposed during 20 sessions with the same volume of exercise training and therapeutic education. After randomisation, patient are allocated to one of the two groups. The evaluation of the primary and secondary outcomes are realized at the beginning, at one month (only walking tests) and at 2 months. A social evaluation is done in parallel to test the acceptability for the Télé-RCV compared with CR.
Methods and apparatuses to apply substances to a biological tissue are described. The tissue having an target below a surface is stretched to provide openings in a surface. Stretching forces a material from the target onto the surface. A first substance may be applied while stretching to promote cleaning the tissue. A second substance may be applied to the surface. Energy may be applied to the tissue. Then the tissue is relaxed to draw the second substance through the openings into the tissue. The tissue may be stretched by applying a negative pressure, and relaxed by removing the negative pressure. The first substance may be an abrasive material. The second substance is a medicine, a moisturizer, a lotion, or any combination thereof. The second substance may be applied to the biological tissue using a positive pressure. The apparatus to apply substances may be a handheld device.
There is described a method and a system for generating a non-imaged plane view of an anatomical part for assisting a surgery. A model of the anatomical part is provided, comprising features and dimension parameters. A first plane view of the anatomical part is obtained. Features are identified in the first plane view. The dimension parameters are measured from the features identified. The model is displayed in the non-imaged plane view such that the model is dimensioned with the measured dimension parameters. A position and orientation of a surgical object is then tracked relative to the anatomical part while a user navigates said surgical object in space and a representation of the surgical object to be overlaid in register on at least one the first plane view and/or the non-imaged view is generated.
Agrobacteria-mediated transformation is widely used in plant genetic engineering to introduce exogenous genes and create mutant lines through random T-DNA insertion and gene disruption. When T-DNA fragments are inserted into the plant genome, it could cause chromosomal abnormalities. In this study, we investigated the genetic basis of pleiotropic phenotypes observed in the T-DNA insertion mutant lnc161. We discovered that there are four T-DNA insertions present in the lnc161 genome, which disrupted the genes LNC161 (AT3G05035), AT3G57400, AT5G05630, and AT5G16450, respectively. However, none of these insertions were the causative mutation that leads to the lnc161 phenotypes. Strikingly, through genetic analyses and high throughput sequencing, we found an inversion of about 19.8 Mb sequences between LNC161 and AT3G57400. Moreover, the sequences between AT5G05630 and AT5G16450 (about 3.7 Mb) were translocated from chromosome 5 to chromosome 3, adjacent to the inversion sequences, and were duplicated. This duplication led to an up-regulation of genes expression in this region, potentially resulting in pleiotropic morphological traits in lnc161. Overall, this study provides a case showing complex chromosomal re-arrangement induced by T-DNA insertion.
Participants will receive RO6958688 with or without obinutuzumab pretreatment QW, Q3W, or according to a combined QW/Q3W step up dosing schedule. Doses will start at 40mg and increase with each administration up to the MTD or 1200mg, whichever is lower.
"Leaky gut" - or, increased permeability of the intestine - involves the leakage of certain intestinal constituents (e.g. endotoxins or even bacteria) from the gut into the rest of the body. This condition is associated with many widespread diseases including coeliac disease, inflammatory bowel disease, HIV, liver cirrhosis, sepsis and environmental enteric dysfunction (EED). It has a considerable impact on quality of life and, in extreme cases (e.g. sepsis), it can even lead to death. Furthermore, in the developing world (as part of EED), it severely hampers the mental and physical development of young children. Thus, new devices that can help us to learn more about leaky gut and more accurately monitor its effects are urgently needed.

In this project, patients will drink a small dose of a fluorescent dye. Then, by shining light on the patients' skin and recording the color and brightness of the light (fluorescence) that comes back, it will be possible to measure the amount of dye that has leaked into the blood (indicating the likelihood that bacteria are escaping from the gut and causing infections). We refer to this as a "Spectroscopic gut permeability test." We will also ask patients to take a traditional permeability test (known as a PEG permeability test) so that we can validate our new sensor. Overall, this research will deliver vital information that will improve our understanding of leaky gut and help guide the development of treatments for the many diseases in which it occurs.
PURPOSE: Biliary atresia (BA) poses a persistent challenge characterized by ongoing liver inflammation and subsequent fibrosis even after the clearance of jaundice (COJ). This study aimed to evaluate the therapeutic potential of eicosapentaenoic acid (EPA) in alleviating liver inflammation and limiting fibrosis during the post-COJ phase of BA.
METHODS: Among the BA patients undergoing laparoscopic Kasai portoenterostomy (lapKP) between December 2016 and October 2021, EPA (20-40 mg/kg/day) was administered orally to those whose parents consented. The study included patients from January 2014 to October 2021, classifying them into two groups: EPA-treated (Group E) and untreated (Group N). Their liver fibrosis and clinical course at 1 and 2 years post-lapKP were compared.
RESULTS: Group E consisted of 25 patients, while Group N comprised 32 patients. Twenty-one patients in Group E and 25 patients in Group N achieved COJ (p = 0.74). Among jaundice-free patients at 1 and 2 years post-lapKP, Group E exhibited significantly lower M2BPGi levels and platelet counts, and Group E showed a significant reduction in Aminotransferase-to-Platelet Ratio Index (APRI) at 2 years post-lapKP.
CONCLUSION: Although EPA administration did not improve COJ, it attenuated the progression of liver fibrosis during the 2 years following lapKP in jaundice-free patients. (200/200Words).
Cerebellar pathology engenders the disturbance of movement that characterizes Friedreich ataxia (FRDA), yet the impact of cerebellar pathology on cognition in FRDA remains unclear. Numerous studies have unequivocally demonstrated the role of the cerebellar pathology in disturbed cognitive, language and affective regulation, referred to as Cerebellar Cognitive Affective Syndrome (CCAS), and quantified by the CCAS-Scale (CCAS-S). The presence of dysarthria in many individuals with ataxia, particularly FRDA, may confound results on some items of the CCAS-S resulting in false-positive scores. This study explored the relationship between performance on the CCAS-S and clinical metrics of disease severity in 57 adults with FRDA. In addition, this study explored the relationship between measures of intelligibility and naturalness of speech and scores on the CCAS-S in a subgroup of 39 individuals with FRDA. We demonstrated a significant relationship between clinical metrics and performance on the CCAS-S. In addition, we confirmed the items that returned the greatest rate of failure were based on Verbal Fluency Tasks, revealing a significant relationship between these items and measures of speech. Measures of speech explained over half of the variance in the CCAS-S score suggesting the role of dysarthria in the performance on the CCAS-S is not clear. Further work is required prior to adopting the CCAS-S as a cognitive screening tool for individuals with FRDA.
Participants will be registered at the care centre and will receive usual care from their care manager who is assigned to them when they register with the centre. Those who are randomised into the intervention arm will undergo 5-sessions of Multi-domain Psychoeducation Self-management Programme over 5 weeks.
The phenomenon of overweight and obesity constitutes a threat for health and children's lives at preschool age. Eating habits formed during this period seriously affect not only future dietary preferences but also the development of diet-related diseases. The purpose of the present study was the assessment of the relationship between the state of knowledge of children's nutrition and parents' eating behaviour and the prevalence of overweight and obesity in children aged 4-6 years. The study was conducted using 200 parent-child pairs. The behaviour and nutritional knowledge of parents was assessed using a questionnaire method. In contrast, anthropometric measurements were taken among the children. Nutritional disorders were noted in 46.5% of children of whom 39.0% struggled with overweight and 7.5% with obesity. The study showed that the children of parents with higher levels of nutritional knowledge were more likely to develop overweight and obesity. It also proved that irregularity of parental food intake predisposed the development of excessive body weight in children (p = 0.0049). Therefore, it is reasonable to undertake further investigation into factors implying the development of nutritional disorders among those youngest. Early recognition of dietary mistakes can contribute to their elimination at an early age.
PURPOSE: Severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 < 80 mmHg is a life-threatening condition. The optimal management strategy is unclear. The aim of this meta-analysis was to compare the effects of low tidal volumes (Vt), moderate Vt, prone ventilation, and venovenous extracorporeal membrane oxygenation (VV-ECMO) on mortality in severe ARDS.
METHODS: We performed a frequentist network meta-analysis of randomised controlled trials (RCTs) with participants who had severe ARDS and met eligibility criteria for VV-ECMO or had PaO2/FiO2 < 80 mmHg. We applied the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology to discern the relative effect of interventions on mortality and the certainty of the evidence.
RESULTS: Ten RCTs including 812 participants with severe ARDS were eligible. VV-ECMO reduces mortality compared to low Vt (risk ratio [RR] 0.77, 95% confidence interval [CI] 0.59-0.99, moderate certainty) and compared to moderate Vt (RR 0.75, 95% CI 0.57-0.98, low certainty). Prone ventilation reduces mortality compared to moderate Vt (RR 0.78, 95% CI 0.66-0.93, high certainty) and compared to low Vt (RR 0.81, 95% CI 0.63-1.02, moderate certainty). We found no difference in the network comparison of VV-ECMO compared to prone ventilation (RR 0.95, 95% CI 0.72-1.26), but inferences were based solely on indirect comparisons with very low certainty due to very wide confidence intervals.
CONCLUSIONS: In adults with ARDS and severe hypoxia, both VV-ECMO (low to moderate certainty evidence) and prone ventilation (moderate to high certainty evidence) improve mortality relative to low and moderate Vt strategies. The impact of VV-ECMO versus prone ventilation remains uncertain.
PROBLEM TO BE SOLVED: To obtain an ornamental metallic product in which allergies to metal is prevented at a low cost by subjecting a specified silane compound to hydrolysis and polycondensation by a phosphoric acid catalyst, coating the surface of ornamental metal therewith, drying the same and executing heat treatment. SOLUTION: A silane compound shown by the formula I or II (in the formulae, R denotes 1-2C linear alkyl groups) is subjected to hydrolysis and polycondensation at room temp. with phosphoric acid or aluminum dihydrogent phosphate as a catalyst. This polycondensate product is applied to the surface of ornamental metal, which is thereafter dried at about 80 deg.C, and furthermore, heat treatment is executed. This heat treatment is preferably executed by three stages of 65 to 85 deg.C×30 to 60min, 130 to 200 deg.C×60 to 90min and >=300 deg.C×>=100min in the case the catalyst is composed of phosphoric acid and by two stages of 65 to 85 deg.C×30 to 60min in the case the catalyst is composed of aluminum dihydrogenphosphate.  In this way, a film high in surface hardness, good in adhesion to metal, in which allergies to metal is suppressed, and furthermore, the adhesion and remaining of fingerprints on the surface are prevented can be obtd.
<P>PROBLEM TO BE SOLVED: To provide a means for improving bitter taste and harsh taste without impairing bioutility, in a calcium L-threonate-containing oral administration preparation.  <P>SOLUTION: This oral administration composition containing the calcium L-threonate is characterized by further containing a sugar alcohol and guar gum and/or gelatin. The sugar alcohol is preferably selected from sorbitol, mannitol, erythritol, threotol, maltitol, xylitol, lactitol, and trehalose. The total content of the sugar alcohol is preferably 10 to 50 mass % based on the total amount of the composition. It is preferable that both the guar gum and the gelatin are contained.  <P>COPYRIGHT: (C)2005,JPO&NCIPI