anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A classification method and a classification device for classifying a level of an age-related macular degeneration are provided. The classification method includes the following. An object detection model and a first classification model are pre-stored. A fundus image is obtained. A bounding box is generated in the fundus image according to a macula in the fundus image detected by the object detection model. An intersection over union between a predetermined area and the bounding box in the fundus image is calculated. A classification of the fundus image is generated according to the first classification model in response to the intersection over union being greater than a threshold.
The middle ear (ME) pressure balance is an important contributor to the maintenance of ME health. ME pressure is a measure of the number of contained gas moles and processes that add or remove gas moles from the relatively fixed volume ME cavity change its pressure. Three routes for ME gas exchange have been identified; 1) passive, gradient-dependent species exchange with the local blood via diffusion across the ME mucosa; 2) passive, gradient-dependent species exchange with the ambient environment via diffusion across the tympanic membrane, and 3) bolus exchange of mixed gases between the nasopharynx and ME during transient openings of the Eustachian tube. Total ME pressure and the trajectory of ME pressure under specified conditions depend on the relative rates of species gas exchanges across these pathways. The ME airspace can be subdivided into two compartments, the anterior tympanum and the posterior mastoid air cell system (MACS). Theory suggests that the transmucosal gas exchange rate for the ME (transMEM) may be different for the tympanum and the MACS and this possibility has important implications with respect to the role of the MACS in ME pressure regulation and protection from ME disease. This study measures the rate of inert gas exchange across the mucosa of the two ME compartments in adults. These data will be fitted to a model of gas exchange parameterized based on the relative surface areas and volumes of the two compartments, and the hypothesis that volume gas exchange across the MACS mucosa is less than that for the tympanum will be tested. The results will be used to reject or confirm one mechanism by which large MACS volume protects from otitis media under certain conditions.
INTRODUCTION: Obesity has previously been correlated with an elevated risk of reproductive system diseases in women. The waist-hip ratio (WHR) has been shown to be correlated with visceral fat, making it one of the most commonly used indicators of abdominal obesity. However, little is known about the relationship between WHR and infertility. Therefore, the aim of this study was to evaluate the effect of the WHR on infertility in women of childbearing age.
METHODS: The study used cross-sectional data from women aged 20-45 who participated in the National Health and Nutrition Examination Survey (NHANES), which was conducted between 2017 and 2020. We collected details of their waist circumference, hip circumference, fertility status, and several other essential variables. We used multivariate logistic regression analysis and subgroup analyses to assess the association between WHR and infertility.
RESULTS: There were 976 participants, with 12.0% (117/976) who experienced infertility. After adjusting for potential confounding factors, our multivariate logistic regression analysis revealed that every 0.1 unit increase in WHR resulted in a more than 35% higher risk of infertility (odds ratio [OR; 95% confidence interval [CI]: 1.35 [1.01∼1.81], p = 0.043). Compared to the group with WHR <0.85, the risk of infertility increased in the group with WHR ≥0.85, with an adjusted OR of 1.74 (95% CI: 1.06∼2.85). When WHR was treated as a continuous variable, it was observed that each 0.1 unit increase in WHR was associated with a relatively high risk in the secondary infertility population after adjusting all covariates, with an OR of 1.66 (95% CI: 1.14∼2.40, p = 0.01). When WHR was analyzed as a categorical variable, the group with WHR ≥0.85 exhibited a significantly higher risk of secondary infertility than the group with WHR <0.85, with the OR of 2.75 (95% CI: 1.35-5.59, p = 0.01) after adjusting for all covariates. Furthermore, the interaction analysis indicated that there was a significant interaction between age status on WHR and the risk of infertility.
CONCLUSION: WHR showed a positive correlation with the risk of infertility. This study highlights the importance of effectively managing abdominal fat and promoting the maintenance of optimal WHR levels to mitigate the progression of infertility, particularly for younger women.
In this study, the training booklet to be used in the education to be given to the participants will be prepared by the researchers. In addition, the content of the prepared training booklet will be presented to participants in the form of a mobile application that can run on smart phones with Android operating system so that participants can follow it. In the content of the mobile application, there will be an interface with the information in the booklet and the video narration of the exercises that the participants should do. This application will be downloadable through the server and then there will be no internet requirement to use the application. The mobile application will be installed on the participants' own phones. The participants will be able to adjust the font size in the application. The participants will see the titles in the booklet and will reach the information by choosing the subject curious about. Participants will also be able to listen to the information in the booklet in the form of an audio recording. In addition, reminder notifications for medications and exercises will be set for participants in the mobile application. In this way, it will be easier for participants to access information, and it will be ensured that participants do not forget participants medication hours and that they do the exercises participants need to do during the day without forgetting. Every day between 18.30-20.30, a questionnaire will be sent to the user to evaluate the amount/time of exercise participants has applied for that day. Thus, it will be ensured that the answers of the participants are sent to the server and the daily follow-up of the participants will be carried out. The device will need internet access to send information. The information sent will be kept on the database and can be easily processed. However, it will be possible to easily access the user's historical information without data confusion. It is planned to store the data on MySql (My Structured Query Language) database. If any update is required to the application, it will be carried out quickly through the server. After the research, the use of the mobile application will be continued and sustainability will be ensured in the postoperative recovery and psychological well-being of the participants.
Techniques for determining presence of cancerous cells in breasts of a subject are described. In an example, transient temperature response data for the breasts is received. The transient temperature response data is then converted to steady state temperature response data. A set of features for the breasts are then extracted based on the steady state temperature response data. The set of features are then analyzed by at least one machine learning model, where the at least one machine learning model is trained based on data obtained from a plurality of subjects with confirmed presence of cancerous cells in the breasts. The presence of cancerous cells in the breasts is determined based on the analysis of the set of features by the at least one machine learning model.
This is an RCT of regular daily use of xylitol (or "birch sugar"), a natural sweetener that has antimicrobial properties, for the prevention of acute otitis media (AOM, primary outcome) as well as upper respiratory tract infections and dental caries (the two secondary outcomes) in preschool aged children. Clinical equipoise over the efficacy of xylitol in preventing AOM - a common and costly condition in early childhood - persists even after the completion of three RCTs by a single research group in Finland and one in the United States. Several clinical trials of xylitol for the prevention of dental caries and other studies have demonstrated that the intervention in this trial (3-5 doses of xylitol per day) is safe, well tolerated and feasible for the study period. This trial will be conducted through the TARGet Kids! research network which is undertaking several CIHR funded RCTs and will leverage existing CIHR funded infrastructure and important collaborations. The nominated principal applicant's salary is supported by a CIHR RCT training grant to develop this RCT under the mentorship of a co-principal applicant who is an experienced trialist. This trial has the potential to transform the management of three common conditions during early childhood from treatment to prevention using a currently underutilized antimicrobial substance.
Aspects of the present invention may include systems and methods for intraocular lens selection using a formula and a deep learning machine to estimate the error of the formula. In an aspect, the disclosure provides a method for intraocular lens selection. The method may include obtaining at least two ocular measurement parameters and a lens selection parameter for an eye. The method may include determining an intraocular lens power based on a formula using the at least two ocular measurement parameters. The method may include determining an estimated error of the formula using a deep learning machine trained on verified post-operative results using intraocular lenses selected by the formula. The method may include adjusting the lens selection parameter based on the estimated. The method may include redetermining the intraocular lens power based on the formula and the adjusted lens selection parameter.
PURPOSE: A composition and a sprayer for preventing toothache are provided to relieve and treat diseases caused by dentin exposure such as cervical caries and dentin hypersensitivity. CONSTITUTION: A spray formulation composition for preventing toothache contains micro-powder which adsorbs to the surface of the dentin. The size of the micro-powder is 50nm-10micrometer. The micro-powder is a mineral material or metal salt. A sprayer includes the spray formulation composition, and a spray container which contains the composition and is used for spraying the composition. The spray container contains a body which receives the composition. The body is connected to a needle which is foldable. [Reference numerals] (AA) Formulation; (BB) SEM image; (CC) Example 11; (DD) Tooth paste formulation; (EE) Example 12; (FF) Mouse wash formulation; (GG) Example 13; (HH) Aerosol formulation(test example 2 of the example 1); (II) Comparative example 5; (JJ) No material treatment(test example 1 of the example 1)
The invention belongs to the field of tumor immunotherapy, and particularly relates to a tumor specific promoter and application thereof. The technical problem to be solved by the invention is that the tumor specific proliferation capacity of the oncolytic adenovirus is limited. The invention solves the problem by providing a core promoter element which has independent function of promoting gene expression, can be independently used as a promoter and can be used as an element for constructing the promoter. The nucleotide sequence is shown as SEQ ID No. 1; or a nucleic acid molecule which has 1 or several base insertions, deletions and/or substitution mutations in the nucleotide sequence shown in the sequence SEQ ID No.1 and still has the function of a promoter. The tumor specific promoter modified by the invention has better tumor specific promoter function, and the oncolytic adenovirus constructed by the promoter has the characteristic of being capable of specifically proliferating in tumor cells but not proliferating in normal cells, and is an excellent immunotherapy medicament aiming at various tumors.
Intensive care units are specialized units where patients with multiple comorbidities are treated. The length of stay in intensive care varies according to the characteristics of the patient, the disease and the center. Prolonged intensive care stay causes an increase in mortality . It has been reported that the severity of the disease as well as the comorbidities of the patients contribute to prolonged stay . One third of patients with stay longer than seven days were evaluated as more fragile than before hospital admission. Prolonged intensive care length of stay leads to an increase in morbidity and mortality, bed demand and costs.

The Braden pressure ulcer scale was developed by Braden et al. in 1987 . Scoring is done under six different headings evaluating sensory perception, humidity, activity, mobility, nutrition and friction/cutting. It has been reported as an effective tool for evaluating pressure ulcer development in intensive care patients. In this scoring system, there are different assessment steps such as mobility, nutrition, sensory perception, etc., which allows the assessment of the functional capacity of the patients at the time of admission. In a study of elderly dementia patients, the Braden scale was found to be effective in predicting 90-day mortality. In a retrospective evaluation of patients with heart failure, the Braden scale was reported to predict 30-day mortality.

The aim of our study is to predict the length of intensive care stay by analyzing the Braden scales calculated on the day of hospitalization.
No evidence of carcinogenicity was found when benazepril was administered to rats and mice for up to two years at doses of up to 150 mg/kg/day. When compared on the basis of body weights, this dose is 110 times the maximum recommended human dose. When compared on the basis of body surface areas, this dose is 18 and 9 times (rats and mice, respectively) the maximum recommended human dose (calculations assume a patient weight of 60 kg). No mutagenic activity was detected in the Ames test in bacteria (with or without metabolic activation), in an in vitro test for forward mutations in cultured mammalian cells, or in a nucleus anomaly test. In doses of 50-500 mg/kg/day (6-60 times the maximum recommended human dose based on mg/m2 comparison and 37-375 times the maximum recommended human dose based on a mg/kg comparison), benazepril hydrochloride had no adverse effect on the reproductive performance of male and female rats.

Pregnancy Categories C (first trimester) and D (second and third trimesters)

See WARNINGS, Fetal/Neonatal Morbidity and Mortality.
The 4-session Motivational Enhancement Therapy (MET) intervention will address alcohol use and HIV medication (ART) adherence. Sessions will be delivered in the CLINIC by a CHW (outreach worker, etc) already providing services in the clinic. The intervention is based on Motivational Interviewing (MI) techniques, building motivation for change by eliciting and reinforcing change talk.
The PART A will be in combination with paclitaxel; the starting dose of 40 mg AZD6738 OD will be escalated to reach a maximum tolerated dose in patients with advanced solid malignancies, as defined by dose-limiting toxicity. The PART B will be an independent parallel PK expansion cohort with cycle 0 of AZD6738 on D1, D8\~D21 monotherapy followed by combination therapy with weekly paclitaxel from cycle 1.
The main challenge to plant productivity is water scarcity, which is predicted to get worse with climate change, particularly in arid and semi-arid areas. Humic acid could improve plant tolerance to mitigate drought damage, which is an effective strategy to improve crop production and agriculture sustainability under limited water conditions in these regions, but its effective application rates should also be established. Thus, two field experiments were carried out at the Qaha Vegetable Research Farm in Qalubia Governorate, Egypt, during the two seasons of 2020-21 and 2021-22 on clay soil. The present study investigated the effect of three rates of humic acid application (0, 4.8, and 9.6 kg ha-1) on growth, yield, and quality of broccoli cv. Montop F1 hybrid under well-watered and drought conditions. Drought was induced by missing alternate irrigation. Soluble humic acid as potassium-humate was applied three times with irrigation water at the time of the first three irrigations of drought treatment. Water-stressed plants had a decrease in growth, yield, leaf chlorophyll, and nutrient content, while they showed an increase in the contents of leaf proline and curd dry matter and total soluble solids as well as water use efficiency, in both seasons. Soil application of humic acid was effective in mitigating the adverse effects of water deficit stress on the growth and yield of broccoli. Water-stressed plants had the highest WUE value (9.32 and 9.36 kg m3-1 in the first and second seasons, respectively) when the maximal humic acid rate was applied. Humic acid at a high level (9.6 kg ha-1) had the most promising results and represents an opportunity that must be applied to improve broccoli yield and its production sustainability in arid and semiarid regions.
After recruiting, patients are assigned to the manual acupuncture group by randomization,and then receive manual acupuncture treatment.Both treatments consist of 24 sessions of 30 minutes duration, administered over 8 weeks (usually three sessions per week). Participants in both groups will be evaluated at baseline, 4 weeks, 8 weeks, 12 weeks and 16 weeks.
FIELD: medicine, venerology. SUBSTANCE: method involves administration of pyrogenal by intramuscular route in a dose from 10 mcg and then adding by 10 mcg per each injection. Treatment course is 10 injections. Inductothermy treatment is carried out from 1-st to 15-th day every day simultaneously. Additionally, beginning from 10-th day of treatment exfusion of circulating (6-8% of volume) followed by removal of plasma and reinfusion of autogenic blood cellular mass after its incubation for 15 min with a single curative dose of metronidazol (0.5 g in 100 ml of physiological solution and 2.0 ml of ATP) is carried out. Course is 6 procedures in 48 h break. EFFECT: enhanced effectiveness of treatment, decreased daily and course doses of anticystocidic agents. 2 cl, 1 dwg, 3 tbl, 1 ex
Human breast milk 5ml would be used as the placebo in this study. It would be indistinguishable from the treatment group as this will also be the diluent used.
INTRODUCTION: Vaginal delivery after caesarean section (VBAC) is recommended, but the rising rate of uterine rupture calls into question the safety of this practice.
AIM: To identify risk factors for uterine dehiscence and rupture.
METHODS: This was a prospective, analytical and descriptive observational study, carried out in a tertiary care maternity. We included all parturients with one previous caesarean section undergoing trial of labor. We assessed the quality of the uterine scar which was evaluated after delivery.
RESULTS: We included 300 patients with one previous caesarean section undergoing trial of labor. The trial of labor was successful (vaginal delivery) in 50.7% of cases. The uterine scar, assessed after delivery, was of good quality in 79% of cases. We noted 7 cases of uterine rupture, i.e. 2.3% of cases, and dehiscence in 56 patients, i.e. 18.6% of cases. Parity, conditions of previous caesarean section (programmed or emergency) and interpregnancy interval were significantly related to the labor outcome (p=0.004, p=0.001 and p=0.135 respectively). The occurrence of rupture or dehiscence was not significantly related to macrosomia, defined as a neonatal weight greater than 4000g (p=0.135).
CONCLUSION: Knowing the risk factors for uterine dehiscence and rupture would enable the obstetrician to properly assess the situation in order to make the correct decision and avoid neonatal and maternal complications.
Hyperbaric oxygen treatment (HBOT) can be utilised for necrotising soft tissue infections, clostridial myonecrosis (gas gangrene), crush injuries, acute traumatic ischaemia, delayed wound healing, and compromised skin grafts. Our case was a 17-month-old male patient with Noonan syndrome, idiopathic thrombocytopenic purpura, and bilateral undescended testicles. Haematoma and oedema developed in the scrotum and penis the day after bilateral orchiopexy and circumcision. Ischaemic appearances were observed on the penile and scrotal skin on the second postoperative day. Enoxaparin sodium and fresh frozen plasma were started on the recommendation of haematology. Hyperbaric oxygen treatment was initiated considering the possibility of tissue necrosis. We observed rapid healing within five days. We present this case to emphasise that HBOT may be considered as an additional treatment option in patients with similar conditions. To our knowledge, no similar cases have been reported in the literature.
This arm will use Medtronic CAPSTONE® PEEK cage supplemented with a pedicle screw system. Both cages will be used in conjunction with a 50:50 mixture of autograft: allograft using milled local autograft bone and GRAFTON™ DBM DBF (no iliac crest autograft will be utilized).
Virtual assistants (VAs) can be managed in interactions with users, other VAs, and devices, including in connection with medical care associated with users. A VA management component (VAMC) can analyze medical information and other information relating to users, including information obtained by a VA(s) from a user(s). Based on the analysis, VAMC can determine a model relating to medical care associated with users. VAMC can determine a proposed action relating to the health or medical care associated with a user based on the model. A VA can present action information relating to the proposed action, or other information relating to health or medical care associated with the user, to the user or a device associated with the user. VAMC can determine drug-drug or drug-food interactions or side effects, and the VA can notify the user regarding the drug-drug or drug-food interactions or side effects.
Consumption of a portion of Itsu Crispy Seaweed Thins equivalent to 200 µg of iodine (10g) consumed with 450 mL water. Collection of urine for 36 hours following ingestion. Collection of one fecal sample up to 24 hours following ingestion.
Initial therapy does not include cardiac catheterization. Cardiac catheterization with possible PCI is allowed after completion of mild therapeutic hypothermia or apyrexia for \>24h post ROSC.
This cohort includes participants with or without subjective complaints whose results of cognitive examination are normal. Participants will undergo clinical, epidemiological, and cognitive assessments, as well as biospecimen collection every two years, over an 8-year follow-up period.