anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIMS: The aim of this study was to characterize the influence of social deprivation on the rate of complications, readmissions, and revisions following primary total shoulder arthroplasty (TSA), using the Social Deprivation Index (SDI). The SDI is a composite measurement, in percentages, of seven demographic characteristics: living in poverty, with < 12 years of education, single-parent households, living in rented or overcrowded housing, households without a car, and unemployed adults aged < 65 years.
METHODS: Patients aged ≥ 40 years, who underwent primary TSA between 2011 and 2017, were identified using International Classification of Diseases (ICD)-9 Clinical Modification and ICD-10 procedure codes for TSA in the New York Statewide Planning and Research Cooperative System database. Readmission, reoperation, and other complications were analyzed using multivariable Cox proportional hazards regression controlling for SDI, age, ethnicity, insurance status, and Charlson Comorbidity Index.
RESULTS: A total of 17,698 patients with a mean age of 69 years (SD 9.6), of whom 57.7% were female, underwent TSA during this time and 4,020 (22.7%) had at least one complication. A total of 8,113 patients (45.8%) had at least one comorbidity, and the median SDI in those who developed complications 12 months postoperatively was significantly greater than in those without a complication (33 vs 38; p < 0.001). Patients from areas with higher deprivation had increased one-, three-, and 12-month rates of readmission, dislocation, humeral fracture, urinary tract infection, deep vein thrombosis, and wound complications, as well as a higher three-month rate of pulmonary embolism (all p < 0.05).
CONCLUSION: Beyond medical complications, we found that patients with increased social deprivation had higher rates of humeral fracture and dislocation following primary TSA. The large sample size of this study, and the outcomes that were measured, add to the literature greatly in comparison with other large database studies involving TSA. These findings allow orthopaedic surgeons practising in under-served or low-volume areas to identify patients who may be at greater risk of developing complications.
OBJECTIVE: Isorhamnetin, a naturally occurring flavonoid compound, holds paramount importance as a primary constituent within several medicinal plants, exhibiting profound pharmacological significance. The aim of this study is to investigate the pain-relieving attributes of isorhamnetin in murine models through both formalin-induced pain and diabetic neuropathy scenarios.
MATERIALS AND METHODS: To achieve our objective, isorhamnetin was orally administered to mice at varying dosage levels (10 to 100 mg/kg). Pain-related behaviors were assessed using the formalin test during its secondary phase. Additionally, the potential pain-alleviating effect of isorhamnetin was evaluated in a diabetic neuropathy model induced by streptozotocin. Additionally, we carried out advanced interventions using naloxone, which is a well-known antagonist of opioid receptors, yohimbine, which blocks α2-adrenergic receptors, and methysergide, which inhibits serotonergic receptors, during the formalin test.
RESULTS: The oral intake of isorhamnetin showed a decrease in behaviors associated with pain that was proportional to the dose observed during the second phase of the formalin test when induced by formalin. In the diabetic neuropathy model, isorhamnetin administration effectively reversed the reduced pain threshold observed. Notably, naloxone, the opioid receptor antagonist, effectively counteracted the pain-relieving effect produced by isorhamnetin in the formalin test, whereas yohimbine and methysergide did not yield similar outcomes. Isorhamnetin also led to a reduction in elevated spinal cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) levels triggered by formalin, with this effect reversed by pre-treatment with naloxone. The compound also suppressed heightened spinal phosphorylated CREB (p-CREB) levels caused by diabetic neuropathy.
CONCLUSIONS: This research determined that isorhamnetin has notable abilities to relieve pain in models of formalin-induced pain and diabetic neuropathy. The pain-relieving mechanism of isorhamnetin in the formalin-induced pain model seems to be connected to the activation of spinal opioid receptors and the adjustment of CREB protein amounts. This insight improves our knowledge of how isorhamnetin could be used therapeutically to treat pain conditions stemming from formalin-induced pain and diabetic neuropathy.
The invention discloses an ointment for treating bedsore, belonging to the technical field of traditional Chinese medicine and traditional Chinese medicines. The ointment comprises the following raw materials: Flos Carthami, Radix et Rhizoma Rhei, Rhizoma Sparganii, Rhizoma Curcumae, Radix Angelicae Sinensis, hair, tortoise plastron and sesame oil. A preparation method of the ointment comprises the following steps: preparing raw materials, pretreating, soaking and decocting and forming the ointment. Based on the basic theories of traditional Chinese medicine and the combination principle of traditional Chinese medicines, the ointment is obtained by combining the modern medical theory and diagnosis and treatment principle according to clinical experiences summary and concentrate on studies. The ointment can activate blood to promote menstruation, remove stasis to ease pain, draw out pus and toxicity, and remove the necrotic tissues and promote granulation, the bedsore can be effectively treated, and the complication can be reduced; and the ointment has a good efficacy on the skin damage disorders of burning, scald and the like. The ointment has the characteristics of being simple for change of medical prescription, dispensing with surgery, and being convenient to treat, the economic and thought burden of patients can be lightened, and the self-care ability of patients can be increased.
The invention discloses an external hot-compress powder, and especially relates to a cervical and lumbar vertebra collateral-freeing hot-compress powder. The hot-compress powder is prepared by grinding and mixing the following raw materials by weight: 30 grams of monkshood, 30 grams of aconitum kusnezoffii, 30 grams of cassia bark, 30 grams of dry ginger, 20 grams of dahurian angelica root, 20 grams of arisaema heterophyllum blume, 20 grams of red peony root, and 30 grams of camphor. The using method of the powder comprises the following steps: mixing and grinding the medicinal raw materials mentioned above into fine powder, weighing 30 to 60 grams of the powder for each time, adding edible vinegar into the powder, blending the mixture into paste, paving the paste on gauze, and finally pasting the gauze on the sore part. The powder is developed on the basis of the nerve distribution, the distribution relationship between the anterior branch and the posterior branch, and is accord with the biomechanics theory and the circulation parts of the muscle and ligament. At the same time, the traditional Chinese medicine theory is also taken into account, the internal organ theory and meridian and collateral theory are utilized, and the overall pain source namely "Tonggen" acupoint is selected. The powder has the functions of freeing the collateral, dissipating cold, dispelling wind, removing dampness, moving stagnation, diminishing stasis, activating blood, and relieving pains, and is capable of treating cervical spondylosis, protrusion of lumbar intervertebral disc, hyperostosis, spinal stenosis, sciatica, shoulder periarthritis, and gonitis under the assistance of acupuncture needle treatment.
The invention discloses an oxidation-responsive PEG lipid, and a preparation method and application thereof. The compound is prepared by linking an acrylic ester derivative with a PEG terminal through monoseleno ether. The raw materials used in the preparation process can be obtained naturally or by simple synthesis. The PEGylation modified lipid has low toxicity and immunogenicity, can realize long circulation of drugs or genes in vivo, improves the utilization efficiency and reduces the biotoxicity. The hydrophilic PEG and the hydrophobic end are connected through a C-Se dynamic covalent bond, so that timely degradation in vivo can be realized under the condition of active oxygen in vivo, the problem that lipid cannot be degraded in the prior art is solved, and meanwhile, effective release of drugs or genes in cells is realized. The carrier can be self-assembled into nano-micelle in water solution, and can be used as lipid to prepare liposome or be fused with cell vesicle for drug or gene delivery.
Background: Alternative treatment therapies to positive upper airway pressure (CPAP) for obstructive sleep apnea syndrome (OSAS) have been developed in recent years. Myofunctional orofacial therapy (MFT) is one of these alternatives and consists of exercises that improve mobility and increase muscle strength of the orofacial structures that contribute to the etiopathogenesis of OSAS. To date, any study to treat sleep apnea patients under this therapy has been conducted in Spain. Moreover, its long-term effect has not been evaluated worldwide.

Main objective: to compare the reduction in the apnea-hypopnea index (AHI) in patients with mild to moderate sleep apnea without daytime sleepiness after 12 months of myofunctional therapy exercises with respect to the placebo group (the placebo group will be instructed in simulation exercises that do not alter the function or morphology of the upper airway) Methodology: A 12-month, randomized, parallel-group, clinical trial will be conducted. Patients with an AHI ≥ 5 events per hour assessed by a respiratory polygraphy (RP) will be randomized to a MFT treatment branch or to another placebo exercises branch. A speech therapist will instruct patients to perform the exercises in both groups for three months. At the end of this period, a RP will be performed on both groups and the same treatment that they were doing will be maintained at home. One year later, a new RP will be performed and changes in AHI, oximetry parameters and snoring will be compared in both groups, as well as sleepiness, quality of life and the degree of adherence to the treatment.
Bortezomib via a short intravenous infusion (3-5 seconds) followed by romidepsin via a 4 hour intravenous infusion weekly x 3 every 4 weeks. In order to identify appropriate doses, different subjects will be treated with different drug doses and observed for the effects, especially the side effects associated with higher doses.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new substituted heterocycles of the general formula (I)   where values R′-R 5 , X are given in p. 1 of the invention claim. Compounds are antagonists of tachykinin receptors and show the efficiency for treatment of patients with inflammatory sicknesses, pains or migraine and asthma. Also, some of these substances are agents blocking calcium channel and they can be benefit for treatment of patients with cardiovascular disorders, for example, angina, hypertensia and ischemia. Invention describes a pharmaceutical composition based on compounds of the formula (I) and a method of blockade of neurokinin-1 receptors in mammals also. EFFECT: improved method of receptor blocking, valuable curative properties. 9 cl, 7 dwg, 67 ex
Participants diagnosed with SMM between 01 January 2016 and 31 December 2021 will be enrolled in this study. Only data available outside of clinical studies from participant medical records will be collected. The data collected per participant in this study is defined as data in medical charts from date of SMM diagnosis until 31 December 2023, death or lost to follow-up, whichever comes first.
Various cytokines have been implicated in cancer cachexia. One such cytokine is IL-6, deemed as a key cachectic factor in mice inoculated with colon carcinoma 26 (C26) cells, a widely used cancer cachexia model. Here we tested the causal role of IL-6 in cancer cachexia by knocking out the IL-6 gene in C26 cells. We found that the growth of IL-6 KO tumors was dramatically delayed. More strikingly, while IL-6 KO tumors eventually reached the similar size as wild-type tumors, cachexia still took place, despite no elevation in circulating IL-6. In addition, the knockout of leukemia inhibitory factor (LIF), another IL-6 family cytokine proposed as a cachectic factor in the model, also affected tumor growth but not cachexia. We further showed an increase in the infiltration of immune cell population in the IL-6 KO tumors compared with wild-type controls and the defective IL-6 KO tumor growth was rescued in immunodeficient mice while cachexia was not. Thus, IL-6 promotes tumor growth by facilitating immune evasion but is dispensable for cachexia.
Methods and systems for genetic diagnosis include splitting genomes into respective groups of non-overlapping windows. The genomes are sampled into sets, each set being made up of selected genomes. A distribution of events is generated across the sets in each window. A tensor is determined for each window based on statistical properties of the distribution of events for the window. A classifier is generated based on the tensors. One or more phenotypes is diagnosed from an input genome using the classifier.
The invention discloses an application of CLEC5A gene in preparing a diagnostic kit and a targeted therapeutic drug for cancer. The invention firstly analyzes the expression of CLEC5A mRNA level in gastric cancer through TCGA and Oncomine databases, and then researches the expression of CLEC5A protein level in gastric cancer tissues by using an immunohistochemical technology. The results indicate that CLEC5A expression was higher in gastric cancer tissues than in normal gastric mucosal tissues both at the mRNA level and at the protein level, and CLEC5A high expression was associated with poor prognosis in patients. In addition, the shRNA sequence specifically designed by the invention can effectively inhibit the expression of CLEC 5A. Through interference of CLEC5A expression by specific shRNA sequences, proliferation, migration and invasion abilities of AGS and HGC27 cells are inhibited to different degrees. Thus, CLEC5A plays a role in promoting the generation and development of gastric cancer, and is helpful for preparing a novel diagnostic kit and preparing a novel targeted therapeutic drug for the cancer with high CLEC5A expression.
In the method crosslinked insoluble polymers with hydrophobic and hydrophilic gps. are used as carrier materials for the medicaments. The medicaments are mixed with the pre-swollen crosslinked polymer by the embedding process. The medicament undergoes a change into an amorphous state, and it is this which gives the improved solubility characteristics. Pref. polymeric carriers are 2-hydroxyethyl methacrylate crosslinked with ethylene dimethacrylate, and crosslinked polyvinylpyrrolidone.
To address this clinical and research need in the current project, the primary aim is to (1) assess the feasibility, acceptability, and appropriateness of a self-guided music listening intervention (i.e. Independent Music Listening or "IML") comprised of 1-hour daily music listening during the inpatient hospitalization (e.g., 3-4 weeks) and delivered via web-based platform/smart phone app (e.g., Spotify or Apple music) among 35 HCT patients. Participants will be randomized to IML (n=23) or usual care control group (n=12). The secondary aims are to (2a) explore whether the IML program is associated with improvements on psychosocial self-report measures of patient quality of life, distress, and mindfulness and (2b) whether preliminary psychosocial effects of the IML program are different from a control group of patients completing usual care. In an exploratory aim, the PI will gather qualitative data on patient perceptions and reactions to daily music listening via a daily music diary and post-intervention open-ended questions. Data produced from the current study will help inform development of future interventions to improve quality of life in HCT patients that are based in arts in medicine or creative arts therapy modalities.
The mainstay orthopedic surgical technique for fracture fixation involves metal plates, screws, and rods. While these methods are effective, they exhibit high rates of complications within specific populations, particularly among patients with pathologic and insufficiency fractures. IlluminOss represents a novel photodynamic bone stabilization system, approved for use in multiple countries, that serves as an alternative to traditional fracture fixation approaches for patients experiencing pathologic, traumatic, and fragility fractures. Despite the initial success of the system in fostering fracture healing, no study has comprehensively examined the radiological attributes of the IlluminOss Stabilization system thus far. The emergency radiologist is often the first point of imaging identification and interpretation for patients presenting with suspected postoperative complications, requiring evolving knowledge of both expected and atypical appearances for novel surgical implants. This manuscript's objective is to delve into the design and clinical application of IlluminOss, scrutinize relevant normal imaging findings across various modalities, and delineate potential complications associated with the IlluminOss Stabilization system for traumatic, pathologic, and fragility fractures that are increasingly encountered in the emergency department setting.
Context: The presence of to is thoracolumbar (TL) mobility a significant aspect in the context of running. Most of the factors may be related to certain kinematic parameters of the lumbopelvic-hip complex during running. Objective: To compare the TL mobility of individuals at different running levels and sedentary individuals. Design: Cross-sectional. Participants: The first group consisted of 35 runners who had been running for the last two years (RTY) while the second group had 35 runners who had been running for the last six months (RSM). The third group had 35 sedentary individuals. Main Outcomes Measures: Sports-related and sociodemographic information was recorded. The Myoton device was used over the Latissimus Dorsi (LD) muscle on both dominant and nondominant sides to measure muscle tone (Hz), elasticity, and stiffness (N/m) values. Trunk flexibility and flexibility of lumbar extensor muscles were measured with tape measurement (cm). The trunk range of motion (ROM, ˚) was measured using goniometer. Thoracolumbar Fascia Length Test and Modified Schober Test were used for thoracolumbar (TLF) fascia flexibility. Analysis of variance was used for statistical analysis. SPSS version 17.0 was used for all statistical analyses. The primary outcome was defined as lumbar extensor tightness. Numeric data obtained from the subjects were presented as mean, standard deviation (mean±SD) and percentage (%). The primary outcome was defined as lumbar extensor tightness. The sample size for each group was calculated to be 30 with a power of 80% and a significance level of 0.05. Considering potential dropouts, 35 participants were included in each group. The groups were not homogenous. As a nonparametric test, the 'Kruskal-Wallis test' was employed for the three-group comparison. The Mann-Whitney U test was used for the two-group comparison. Statistical significance was set at P \< .05.
Patients with primary ITP and aged 18 and older will be included in the study. Patients under 18 and those with proven secondary ITP \[as cases initiated by or associated with infections due to human immunodeficiency virus (HIV-associated), hepatitis B virus, or hepatitis C virus-associated secondary ITP\] will be excluded. Moreover, patients with accompanying autoimmune disorders such as systemic lupus erythematosus (SLE) and patients of malignancies were excluded.
The patients admitted in hospital who had midline catheter inserted in upper limb are followed-up for the presence of complications related to catheter introductions. The symptoms and signs of upper limb thrombosis are recorded. The diagnosis is confirmed by sonography examination. The age, gender, principal diagnosis, the vein were midline catheter is inserted and number of vein punctures for catheter insertion are recorded. Afterward the patients are treated in the ward and the possible complications are recorded. The main concern is about the incidence of upper limb thrombosis. All the complications are recorded as well as date when they has appeared. The statistical analysis is done in order to evaluate the incidence of upper limb symptomatic thrombosis, the duration since insertion to thrombosis manifestation ańad its associations with age, gender, principal diagnosis, selected vein, its size and number of punctures is analysed.

In the selected group of the asymptomatic patients 8 to 10 days after midline insertion upper limb sonography is done in order to detect the presence of the asymptomatic upper limb thrombosis and the same type of analysis as for symptomatic thrombosis is undertaken.
Complex protein walled microcapsules (40) incorporate lipid-walled microcapsules (48) that include constituents to be retained in the presence of hydration such as water soluble vitamins and minerals. The protein walled microcapsules (40) are cross-linked, and include constituents (46) that are excluded from the lipid-walled microcapsules (48) and which are leachable from the protein walled microcapsules upon hydration. Other constituents (42 and 44), such as high molecular weight compounds and particulates may also be included in the protein walled microcapsules (40). Preferably, these other constituents (42 and 44) are chosen to be retained within the protein-walled microcapsules (40) upon hydration. In a preferred embodiment, the complex protein-walled microcapsules are used as a fish larvae diet, wherein low molecular weight constituents, such as amino acids, that are incorporated into the protein-walled microcapsule but excluded from the lipid-walled microcapsule, are chosen for use as phagostimulants and attractants. They are leached out from the protein-walled microcapsule upon hydration. Nutrients such as vitamins and minerals are retained in the lipid-walled capsules of the complex protein-walled microcapsules. Larvae are stimulated from the leached phagostimulants and ingest the complex protein walled microcapsule as food, wherein the encapsulated water soluble vitamins and minerals, as well as the protein itself serve as nutrients for the larvae.
Generic name: Sterile sodium hyaluronate solution; Dosage form: solution; Dosage: 40mg/50ml; Frequency and duration: The first 4 weeks were irrigated once a week, a total of 4 times, and the last 4 months were irrigated once a month, a total of 4 times. The total treatment cycle was 5 months, and a total of 8 bladder perfusion treatments were performed.
An optimization method of an extraction process of total flavonoids of clematis filamentosa dunn relates to an optimization method of an extraction process. The invention aims to solve the problem that stable extraction of Gan Mutong total flavonoids is difficult to realize by taking clematis filamentosa as a raw material. The invention takes the clematis filamentosa dunn as an experimental raw material, utilizes an ultrasonic technology, takes a single-factor test result as a basis, utilizes a response surface molecular method to optimize the process, measures the antioxidant activity of Gan Mutong total flavonoids, and provides theoretical support for further development and utilization of the clematis filamentosa dunn. A stable and feasible extraction process can be obtained. The invention adopts a response surface method to optimize the extraction process of the clematis filamentosa dunn total flavonoids, and the process is stable, feasible, scientific and reasonable. The obtained caulis Clematidis Armandii total flavone has strong antioxidant activity, and can be used as natural antioxidant.