anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An accurate prognosis of renal function decline in Autosomal Dominant Polycystic Kidney Disease (ADPKD) is crucial for early intervention. Current biomarkers used are height-adjusted total kidney volume (HtTKV), estimated glomerular filtration rate (eGFR), and patient age. However, manually measuring kidney volume is time-consuming and subject to observer variability. Additionally, incorporating automatically generated features from kidney MRI images, along with conventional biomarkers, can enhance prognostic improvement. To address these issues, we developed two deep-learning algorithms. Firstly, an automated kidney volume segmentation model accurately calculates HtTKV. Secondly, we utilize segmented kidney volumes, predicted HtTKV, age, and baseline eGFR to predict chronic kidney disease (CKD) stages >=3A, >=3B, and a 30% decline in eGFR after 8 years from the baseline visit. Our approach combines a convolutional neural network (CNN) and a multi-layer perceptron (MLP). Our study included 135 subjects and the AUC scores obtained were 0.96, 0.96, and 0.95 for CKD stages >=3A, >=3B, and a 30% decline in eGFR, respectively. Furthermore, our algorithm achieved a Pearson correlation coefficient of 0.81 between predicted and measured eGFR decline. We extended our approach to predict distinct CKD stages after eight years with an AUC of 0.97. The proposed approach has the potential to enhance monitoring and facilitate prognosis in ADPKD patients, even in the early disease stages.
PURPOSE: A functional food containing foods and herbs for treating and preventing arthritis without side effects is provided. CONSTITUTION: A composition for treating arthritis contains 1-2 weight parts of Woodwardia japonica Smith., 1-2 weight parts of Phlomis maximowiczii Rgl., 1-2 weight parts of Acyranthes bidentata Blume, and 1-2 weight parts of Plantaginis Semen. The Woodwardia japonica Smith. is used after dipping in Soju liquor and streaming. The composition is a pharmaceutical composition or health food. A method for manufacturing the composition for treating arthritis comprises: a step of steaming Woodwardia japonica Smith. in Soju liquor and drying; a step of washing and drying Phlomis maximowiczii Rgl., Acyranthes bidentata Blume, and Plantaginis Semen; a step of adding 10-40 weight parts of purified water; a step of heating at high pressure; and a step of filtering the extract.
The present invention relates to a botanical, and discloses use of kadsura heteroclita (roxb.) craib agent in preparation of a medicament for resisting rheumatoid arthritis. The Kadsura heteroclita (roxb.) craib agent can effectively inhibit proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RAFLS), effectively inhibit the production of inflammatory factors TNF-α, IL-1β and IL-6 of RAFLS induced by lipopolysaccharides, increase the expression level of IL-10, and has a good anti-inflammatory effect. Furthermore, the agent can effectively inhibit the incidence of arthritis in rat induced by AIA, reduce the swelling degree of toes of rats, and improve pathological and radiological image changes in the toes of rats. Also disclosed is a medicament taking the Kadsura heteroclita (roxb.) craib agent as an active ingredient, which can be prepared into a plurality of dosage forms such as tablets, capsules or injections, and is used for inhibiting pathological changes caused by rheumatoid arthritis and preventing bone joint damage.
To acquire useful information from a user.SOLUTION: An information processing system comprises a portable terminal. The portable terminal detects sensor information for determining an emotion of a user. The sensor information may be information of a sound detected by a microphone, or information of an image imaged by a camera. The information processing system determines an emotion of a user on the basis of the sensor information. The portable terminal detects the sensor information in a period in which the portable terminal it self is in a standby state. As the standby state, for example, there is a state in which a display of the portable terminal is extinguished.SELECTED DRAWING: Figure 11
SEGLUROMET can cause intravascular volume contraction which may sometimes manifest as symptomatic hypotension or acute transient changes in creatinine [see Adverse Reactions (6.1)]. There have been postmarketing reports of acute kidney injury, some requiring hospitalization and dialysis, in patients with type 2 diabetes mellitus receiving SGLT2 inhibitors, including SEGLUROMET. Patients with impaired renal function (eGFR less than 60 mL/min/1.73 m2) [see Use in Specific Populations (8.6)], elderly patients, patients with low systolic blood pressure, or patients on loop diuretics may be at increased risk for volume depletion or hypotension. Before initiating SEGLUROMET in patients with one or more of these characteristics, assess volume status and renal function. In patients with volume depletion, correct this condition before initiating SEGLUROMET. Monitor for signs and symptoms of volume depletion, and renal function after initiating therapy.
The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.
Infection with human papillomavirus (HPV) is a major risk factor for head and neck squamous cell carcinoma (HNSCC). The objective of this study is to investigate the gene expression profiles and signaling pathways that are specific to HPV-positive HNSCC (HPV+ HNSCC). Moreover, a competing endogenous RNA (ceRNA) network analysis was utilized to identify the core gene of HPV+ HNSCC and potential targeted therapeutic drugs. Transcriptome sequencing analysis identified 3,253 coding RNAs and 3,903 non-coding RNAs (ncRNAs) that exhibited preferentially expressed in HPV+ HNSCC. Four key signaling pathways were selected through pathway enrichment analysis. By combining ceRNA network and protein-protein interaction (PPI) network topology analysis, RNA Polymerase II Associated Protein 2 (RPAP2), which also exhibited high expression in HPV+ HNSCC based on the TCGA database, was identified as the hub gene. Gene set enrichment analysis (GSEA) results revealed RPAP2's involvement in various signaling pathways, encompassing basal transcription factors, ubiquitin-mediated proteolysis, adherens junction, other glycan degradation, ATP-binding cassette (ABC) transporters, and oglycan biosynthesis. Five potential small molecule targeted drugs (enzastaurin, brequinar, talinolol, phenylbutazone, and afuresertib) were identified using the cMAP database, with enzastaurin showing the highest affinity for RPAP2. Cellular functional experiments confirmed the inhibitory effect of enzastaurin on cell viability of HPV+ HNSCC and RPAP2 expression levels. Additionally, enzastaurin treatment suppressed the expression levels of the top-ranked long non-coding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA) in the ceRNA network. This study based on the ceRNA network provides valuable insights into the molecular mechanisms and potential therapeutic strategies for HPV+ HNSCC, and provide theoretical basis for the exploration of HPV+ HNSCC biomarkers and the development of targeted drugs.
Participants randomized to the Usual Care (UC) group will use their existing insulin delivery method in conjunction with a study CGM during the first 13-week of the study (RCT phase). The UC group will then initiate use of the BP System for the remaining 13 weeks of the study (Extension Phase).
Repeated transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for a 5-day period (1 day before surgery and 4 consecutive days after surgery, twice daily \[10-12 am and 4-6 pm\]). Parameters of rTMS: "8" shaped coil, 10 Hz, 80% resting motor threshold (RMT), 2000 pulses (5s × 40 trains, 25 s interval), 20 minutes.
The present invention provides bupleurum root oily emulsion injection liquid and a production method thereof, which relates to emulsion medicine which has the effects for reducing fever by reconciliation, dredging muscles to remove heat, resisting inflammation, lifting yang qi, etc. and is suitable for intravenous injection and intramuscular injection. According to the design scheme provided by the present invention, the bupleurum root oily emulsion injection liquid has the components with the weight portions: 2000 portions of bupleurum root volatile oil extracted from bupleurum root powder, 10.0 to 100 portions of soybean oil for injection, 11 to 13 portions of soybean phospholipid for injection, 24 to 26 portions of glycerol for injection and 3.0 to 20 portions of poloxamer 188. The production method of the bupleurum root oily emulsion injection liquid is characterized in that the production method has the steps: (1) extracting and collecting bupleurum root volatile oil; (2) preparing oil phases; (3) preparing water phases and primary emulsion; (4) preparing bupleurum root oily emulsion injection liquid. The volatile oil is separated from water to obtain pure volatile oil, and water soluble impurities are removed, so that the side effects of the bupleurum root injection liquid are reduced, the stability of the bupleurum root volatile oil is enhanced and the stimulation is lowered. The present invention can be used for intravenous injection and intramuscular injection, can enhance the curative effects of medicine and the compliance of patients, and can meet the requirements of clinical medication.
A method and a device for determining a presence of tumor are provided. The method includes receiving a medical image associated with a patient. The medical image includes a region of interest associated with the patient. The method includes identifying one or more blood vessels associated with the region of interest in the medical image. The method includes determining a set of characteristics associated with the one or more blood vessels using a trained machine learning model. The method also includes determining whether the one or more blood vessels are feeder vessels associated with the tumor based on the set of characteristics associated with the one or more blood vessels. The method includes detecting a tumor region in the region of interest based on the feeder vessels, when the one or more blood vessels are the feeder vessels associated with the tumor.
We will apply evidence-based Problem Solving Therapy (PST), a transdiagnostic, low-intensity approach shown to improve mental health problems among adolescents with demonstrated effectiveness in global settings. PST for adolescents is a brief 5 session individual treatment with demonstrated efficacy when delivered by lay providers. PST is theorized to function by increasing adolescent capacity to cope with perceived and experienced stress through the use of problem- and emotion- focused coping skills that then allow engagement in positive, healthy activities.
This invention is a skin care product and method for making same. The skin care product includes at least one capsule, the capsule comprising a matrix, one or more active ingredients incorporated or contained in the matrix, where at least the matrix has a high affinity with Reactive Oxygen Species (ROS). In an embodiment of the invention, at least one antioxidant agent is incorporated in the matrix. A capsule is a lipid particle. In an embodiment of the invention, the skin care product comprising the capsules is used for topical inhibition of Reactive Oxygen Species ROS in the skin of a person. A method for making the capsule is also disclosed.
During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication channels. Pannexin (Panx) family and connexin (Cx) family are two important types of channel-forming proteins. Panx family contains three members (Panx1-3) and is expressed widely in bone, cartilage and muscle. Although there is no sequence homology between Panx family and Cx family, they exhibit similar configurations and functions. Similar to Cxs, the key roles of Panxs in the maintenance of physiological functions of the musculoskeletal system and disease progression were gradually revealed later. Here, we seek to elucidate the structure of Panxs and their roles in regulating processes such as osteogenesis, chondrogenesis, and muscle growth. We also focus on the comparison between Cx and Panx. As a new key target, Panxs expression imbalance and dysfunction in muscle and the therapeutic potentials of Panxs in joint diseases are also discussed.
The application provides an automatic doctor's advice task execution method, equipment and medium for inpatients, and belongs to the technical field of intelligent robots. The method receives an order task execution request; based on the doctor's advice task execution request and the position of the ward to be nursed corresponding to the patient to be nursed, a corresponding initial nursing planning map is determined. A number of planned care paths corresponding to the at least one blood pressure measurement robot are acquired. It is determined whether there is another order task execution request for each planned care path that conflicts with an order task execution request corresponding to the patient to be cared for. If not, updating each planned nursing path according to the corresponding planned nursing paths and the initial nursing planning map so as to add the nursing arrival path corresponding to the position of the ward to be nursed to the planned nursing path, so that the blood pressure measuring robot sequentially executes doctor's advice tasks corresponding to the planned nursing paths through the planned nursing paths. By the method, labor cost in blood pressure measurement task is reduced.
Patients allocated in this arm will be meassured at the start, again after 30 days and at the end of the physical therapy usual care with a pragmatic perspective. Then will be meassured again after 1 and 3 months.
Agent-based models have gained traction in exploring the intricate processes governing the spread of infectious diseases, particularly due to their proficiency in capturing nonlinear interaction dynamics. The fidelity of agent-based models in replicating real-world epidemic scenarios hinges on the accurate portrayal of both population-wide and individual-level interactions. In situations where comprehensive population data are lacking, synthetic populations serve as a vital input to agent-based models, approximating real-world demographic structures. While some current population synthesizers consider the structural relationships among agents from the same household, there remains room for refinement in this domain, which could potentially introduce biases in subsequent disease transmission simulations. In response, this study unveils a novel methodology for generating synthetic populations tailored for infectious disease transmission simulations. By integrating insights from microsample-derived household structures, we employ a heuristic combinatorial optimizer to recalibrate these structures, subsequently yielding synthetic populations that faithfully represent agent structural relationships. Implementing this technique, we successfully generated a spatially-explicit synthetic population encompassing over 17 million agents for Shenzhen, China. The findings affirm the method's efficacy in delineating the inherent statistical structural relationship patterns, aligning well with demographic benchmarks at both city and subzone tiers. Moreover, when assessed against a stochastic agent-based Susceptible-Exposed-Infectious-Recovered model, our results pinpointed that variations in population synthesizers can notably alter epidemic projections, influencing both the peak incidence rate and its onset.
BACKGROUND: Surgical exploration and closure of the tunica albuginea is the recommended treatment for penile fractures. The recovery of sexual function is the main result that surgeons and patients pursue.
OBJECTIVE: We sought to evaluate the sexual health effects of a surgically corrected penile fracture. Secondarily, we sought to identify risk factors that may influence long-term sexual function and their effects on genital body image satisfaction.
METHODS: A retrospective analysis of patients who underwent surgical correction of penile fractures between 2007 and 2022 in a tertiary center was performed. Lesion characteristics, weeks until the resumption of sexual activity, and post-operative sexual function were recorded. The presence of glans hypoesthesia, penile deformation, penile nodule palpation, and self-satisfaction with body image were assessed.
RESULTS: Sixty-nine patients with a mean age of 42.30 ± 12.98 years and a median follow-up of 70 (20-134) months were identified. Sexual intercourse was recorded as a percentage. Penile deformation was the most common complication, appearing in 14.5% of patients, erectile dysfunction in 5.8%, penile nodules in 4.3%, and glans hypoesthesia in 2.9%. The median post-operative International Index of Erectile Function-5 was 24 (21.5-24). Self-satisfaction with body image had a median of 9 and was negatively associated with bilateral lesions and penile deformation.
DISCUSSION AND CONCLUSION: Distal fractures could be linked to erectile dysfunction and glans hypoesthesia. Surgical correction of penile fractures shows positive functional and self-reported outcomes, and the potential andrological complications rarely necessitate specific treatment.
The nurses (n=3) involved in the biofeedback portion of the UW LUTD Program will undergo a Nurse Training Session where they will be asked to "think aloud" while completing an outlined scenario. Their feedback will be used to update the software to make it more user friendly. After the session, they will be asked to complete the System Usability Scale (SUS). Additionally, after guiding patients through biofeedback sessions using the new software, they will be asked to complete the Nurse Feedback Form.
Antimicrobial stewardship based on daily clinical assessment of clinical cure (experimental group). Discontinuation of antibiotic therapy antibiotics if criterions of clinical cure (regression of tracheal secretions, regression of temperature, improvement of PaO2/FiO2 ratio, absence of hemodynamic failure) of confirmed VAP are met. In the intervention group, intensivists will perform clinical assessment daily in order to decide on the pursuit or discontinuation of antibiotic therapy.
INTRODUCTION: Heterotopic ossification is a pathologic extra-skeletal bone formation as a form of aberrant repair process with acquired or genetic etiologies. In plastic surgery, it has been well-described in the burn and trauma patients. Rarely, it can happen along the vascular pedicle of free tissue transfer, and when it happens, it is most commonly in head and neck reconstruction.
CASE PRESENTATION: Here we present a case of complete extensive heterotopic ossification of the entire vascular pedicle from the anastomosis to the bone in an osteocutaneous free fibula flap (FFF). The fibula was used as a 2-segment reconstruction for a maxillary defect resulting from a self-inflicted gunshot wound. The skin paddle was used to reconstruct the anterior palatal defect.
DISCUSSION: Heterotopic ossification of the FFF vascular pedicle is most reported in the head and neck reconstruction cases. It is rare, but when it happens, it occurs earlier, more commonly, and more extensively in cases of maxillary reconstruction than in cases of mandibular reconstruction. Flap loss due to this sequela has not been reported, and surgical debridement is indicated only when symptomatic.
CONCLUSION: Heterotopic ossification of an FFF vascular pedicle is a rare but well-described entity. The periosteal bone formation capacity preservation after revascularization of the flap is thought to be one of the major etiologies of this phenomenon. Hence, some have suggested a modification in the harvesting technique of the FFF that could mitigate return to the operating room, especially when it is for maxillary reconstruction in the trauma patient. Keywords: Keywords: free fibula flap, heterotopic ossification, maxillary reconstruction, mandibular reconstruction.
PURPOSE:To prepare a bone-fortifying food, pharmaceutical or feed enabling the absorption of large amounts of whey protein and peptide and effective for fortifying the bone by using a water-soluble fraction of whey protein as a component. CONSTITUTION:Whey is a transparent yellowish green liquid obtained as a by-product of a cheese or casein preparation process and produced by adding an acid or rennet to milk or defatted milk and removing the coagulum from the mixture. Whey protein is a water-soluble protein produced by the ultrafiltration, reverse osmosis, chromatography, dialysis, etc., of the whey. The protein to be used in the present product is preferably a water-soluble fraction of a whey protein having a molecular weight of 10,000-45,000 and an isoelectric point of PI 3-8. In the case of performing an enzymatic decomposition with a proteinase, the solution or suspension of the protein is added with a proteinase and subjected to enzymatic decomposition. A proteinase- decomposition product having a molecular weight of about 20,000-300 can be produced by adjusting the solution or suspension of the protein to the optimum pH and optimum temperature for the enzyme, adding the enzyme to the solution, etc., and subjecting the solution to enzymatic reaction for a prescribed time in a stationary state or under stirring.
BACKGROUND: Compared to monetary rewards, depressive symptoms are specifically associated with abnormal social reward processing. In addition, individuals with melancholic depression may exhibit more significant reward-related impairments. However, there is still limited understanding of the specific alterations in social reward processing in individuals with melancholic depression.
METHODS: Forty patients with melancholic major depressive disorder (MDD), forty patients with non-melancholic MDD, and fifty healthy controls participated in the social incentive delay (SID) tasks with event-related potential (ERP) recording. We measured one anticipatory ERP(cue-N2) and two consummatory ERPs (FRN, fb-P3). Furthermore, we examined correlation between FRN and consummatory anhedonia.
RESULTS: Melancholic MDD patients showed less anticipation of social rewards (cue-N2). Concurrently, melancholic individuals demonstrated diminished reception of social rewards, as evidenced by reduced amplitudes of FRN. Notably, the group x condition interaction effect on FRN was significant (F (2, 127) = 4.15, p = 0.018, η2ρ = 0.061). Melancholic MDD patients had similar neural responses to both gain and neutral feedback (blunted reward positivity), whereas non-melancholic MDD patients (t (39) = 3.09, p = 0.004) and healthy participants (t (49) = 5.25, p < 0.001) had smaller FRN amplitudes when receiving gain feedback relative to neutral feedback. In addition, there was a significant correlation between FRN and consummatory anhedonia in MDD patients.
CONCLUSIONS: Our findings indicated that individuals with melancholic MDD exhibit attenuated neural responses to both anticipated and consumed social rewards. This suggests that aberrant processing of social rewards could serve as a potential biomarker for melancholic MDD.