anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Introduction: Many activities of daily livings involve performing two tasks simultaneously, i.e. dual tasking. Performing dual task increases the demand on attentional resources, which may further decrease the dual task performance, especially in older adults. According to capacity sharing theory, the two tasks compete and influence with each other due to limited attention and information processing capacity. It has been noted that task prioritization during dual tasking may influence the dual task performance. Previous study indicated that supraposture-focus strategy resulted in better posture and task performance in older people. On the other hand, it is known that dual task training improved dual task performance. However, the effects of applying task prioritization during dual task training have not yet been investigated. Therefore, the purpose of this study is to investigate the effect of different task prioritization during dual task training on dual task performance.

Methods: Participants will be randomized into three groups: posture-focus, supraposture-focus and control group. Participants will receive a total of 12 sessions of cognitive dual task training with different prioritization strategies, i.e. prioritization on posture, cognitive or neither task. Walking and task performance during dual task walking, executive function, and balance performance will be assessed before and after the interventions (pre- and post-test).
Topiramate is not extensively metabolized and is primarily eliminated unchanged in the urine (approximately 70% of an administered dose). Six metabolites have been identified in humans, none of which constitutes more than 5% of an administered dose. The metabolites are formed via hydroxylation, hydrolysis, and glucuronidation. There is evidence of renal tubular reabsorption of topiramate. In rats, given probenecid to inhibit tubular reabsorption, along with topiramate, a significant increase in renal clearance of topiramate was observed. This interaction has not been evaluated in humans. Overall, oral plasma clearance (CL/F) is approximately 20 to 30 mL/min in humans following oral administration.
Patients receive yttrium Y 90 basiliximab IV on days -21 and -14, carmustine IV over 1-2 hours on days -7 and -6, cytarabine IV BID on days -5 to -2, etoposide IV BID on days -5 to -2, and melphalan IV on day -1. Patients undergo autologous hematopoietic stem cell transplant on day 0.
The present invention relates to a quickly-acting analgesic liniment and a preparing method thereof. The liniment comprises the main medicine components of notoginseng, calcined alum, sappan wood, dragon's blood and borax. The notoginseng, the sappan wood, the borax and the calcined alum are uniformly mixed, and then, ethyl alcohol of the concentration of 70 to 80% is added to the mixture to soak the mixture for 60 to 85 hours. Subsequently, the mixture is filtered, and the residual medicine dregs after filtration is squeezed. After extracted liquid and squeezed liquid are mixed and still arranged, the dragon's blood and borneol are added and dissolved into the mixed liquid. Then, ethyl alcohol of the concentration of 70 to 80% is added into the mixed liquid, uniformly shaken and filtered in a clarification way to obtain the quickly-acting analgesic liniment. The liniment is used for treating symptoms, such as joint bone and muscle pain, purple bruise and tumefaction caused by traumatic injury and contusion sprain.
A Rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in matrix mixture system. The acrylic pressure-sensitive adhesive may be present in an amount of about 1-25% by weight in the matrix mixture system. The silicone pressure-sensitive adhesive may be present in an amount of about 65-98% by weight in the matrix mixture system. The composition further includes 1-40% of Rotigotine on the basis of the total weight of the composition. The composition provides improved properties in the solubility, release and initial penetration level of Rotigotine. Also disclosed is a transdermal patch that includes the Rotigotine-containing composition, as well as methods of manufacturing and using the Rotigotine-containing composition.
Glioblastoma multiforme (GBM) represents the deadliest tumor among brain cancers. It is a solid tumor characterized by uncontrolled cell proliferation generating the hypoxic niches in the cancer core. By inducing the transcription of hypoxic inducible factor (HIF), hypoxia triggers many signaling cascades responsible for cancer progression and aggressiveness, including enhanced expression of vascular endothelial growth factor (VEGF) or antioxidant enzymes, such as heme oxygenase-1 (HO-1). The present work aimed to investigate the link between HO-1 expression and the hypoxic microenvironment of GBM by culturing two human glioblastoma cell lines (U87MG and A172) in the presence of a hypoxic mimetic agent, deferoxamine (DFX). By targeting hypoxia-induced HO-1, we have tested the effect of a novel acetamide-based HO-1 inhibitor (VP18/58) on GBM progression. Results have demonstrated that hypoxic conditions induced upregulation and nuclear expression of HO-1 in a cell-dependent manner related to malignant phenotype. Moreover, our data demonstrated that the HO-1 inhibitor counteracted GBM progression by modulating the HIFα/HO-1/VEGF signaling cascade in cancer cells bearing more malignant phenotypes.
Gloves and socks developed by the researcher are applied half an hour before the operation. These materials, called environmental warming, have three layers. The first layer in contact with the patient is a thermal inner sheath made of 90% Polyester and 10% Polyamide and is used to maintain body temperature. The second layer consists of carbon fiber warmer and foil. The end of the carbon fiber warmer is USB connected. When the connection is plugged in, the warmer works. The third layer is again made of thermal fabric. A rubber bandage is made to separate the last layer from the external environment and to maintain the patient's body temperature. The USB connection is removed while patients are sent for surgery. After the operation, rewarming is started in the post-anesthesia care unit. When the patient's body temperature reaches 36 ° C, he is transferred to the clinic with a cover and blanket.
Study 2 was a multicenter, double-blind, placebo controlled, clinical trial in adult patients with recurrent high-grade glioma. Patients were required to have had prior definitive external beam radiation therapy sufficient to disqualify them from additional radiation therapy. Following maximal tumor resection and confirmation of high-grade glioma, a total of 222 patients were randomized (1:1) to receive a maximum of eight GLIADEL Wafers (n=110) or matched placebo wafers (n=112) positioned to cover the entire resection surface. All patients were eligible to receive chemotherapy which was withheld at least four weeks (six weeks for nitrosoureas) prior to and two weeks after surgery. Patients were followed for up to 71 months.

The population in Study 2 was 64% male and 92% White, and the median age was 49 years (range: 19-80). Sixty-five percent had a histologic subtype of glioblastoma, 26% had anaplastic astrocytoma or another anaplastic variant, 73% had a Karnofsky performance status ≥ 70, 53% had a Karnofsky performance status of ≥ 80%, 73% had only one prior surgery, and 46% had prior treatment with nitrosourea. Eighty-one percent of patients received 8 wafers and 96% received ≥ 6 wafers.

Survival and 6-month mortality rate in the subgroup of patients with recurrent glioblastoma, were exploratory outcome measures and are summarized in Table 7 and Figures 7 and 8. No survival prolongation was observed in patients with pathologic diagnoses other than glioblastoma.

Figure 7: Kaplan-Meier Curves of 6-Month Survival for Patients with Recurrent Glioblastoma, Study 2.

Figure 8: Kaplan-Meier Curves of Overall Survival for Patients with Recurrent Glioblastoma, Study 2.
Morbid obesity and its accompanying diseases have become one of the most serious public health problems warranting global effort and bariatric and metabolic surgery is still the most effective method for long-term weight control. Among all bariatric and metabolic procedures, sleeve gastrectomy is currently the most widely used, but it is not a perfect procedure. One of the most serious issues that this surgical procedure faces is the possibility of worsening existing or developing de novo gastroesophageal reflux disease after surgery. Moreover, there is currently a lack of high-level clinical trial evidence on the diagnosis and treatment of gastroesophageal reflux disease in patients undergoing sleeve gastrectomy. Therefore, initiated by four domestic bariatric and metabolic surgery centers, 41 experts with rich experience in bariatric and metabolic surgery and diagnosis and treatment of gastroesophageal reflux disease from China, Japan, and South Korea reached a consensus on the diagnosis and treatment of gastroesophageal reflux disease in sleeve gastrectomy patients using the Delphi method. There are a total of 59 consultation questions in this consensus, of which 44 have reached a consensus. We hope that this consensus can not only serve as a reference for clinical diagnosis and treatment, but also provide more possible directions for future high-quality clinical research.
FIELD: organic chemistry. SUBSTANCE: product - cyclic aminocompound of the formula 1   where R - pyridyl, piperidyl or pyrrolidinyl each of which can be substituted with lower alkyl, lower alkylcarbonyl, carbobenzoxy, naphthylcarbonyl (lower) alkyl, phenylhydroxy (lower) alkyl, phenylcarbonyl (lower) alkyl or phenyl (lower) alkyl each of which can be substituted with halogen atom or lower alkoxy; p = 1 or 2; A - bond or two - or trivalent aliphatic C 1-6  - hydrocarbon residue which can be substituted which lower alkyl, OXO, hydroxyimino or hydroxy-group.   - a simple or double bond at the following condition: when A - is a bond then   means simple bond; R 2  - and R 3  - are independently hydrogen atom or lower alkyl which can be substituted with phenyl or piperidyl at condition that both R 2  and R 3  are not hydrogen atom; or R 2  and R 3  together with adjacent nitrogen atom form piperidine, hexamethyleneimine-group, morpholine, pyrrolidine, piperazine or 1-imidazole group each of which can be substituted with lower alkyl, lower alkylcarbonyl or diphenyl (lower) alkyl or its physiologically acceptable additive acid salt. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 10 tbl
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant,(Ozurdex®)in patients with diabetic macular edema.Diabetic macular edema is important cause of visual impairment in patients with diabetes mellitus. Focal/ grid laser photocoagulation is the standard of care in its management. Several adjuncts including intravitreal corticosteroids, Pegabtanib Sodium ,Ranibizumab, Bevacizumab, non-steroidal anti-inflammatory agents, corticosteroids, laser photocoagulation have been tried. Intravitreal Triamcinolone Acetonide (TA), a water insoluble steroid, has been shown to reduce the retinal thickness and improve the visual acuity. However, recurrence of macular edema in patients who receive intravitreal TA is a major concern as the patients need multiple repeat injections because of its short half life. A more potent steroid, dexamethasone has also been tried as an alternative to TA for macular edema; however, its short half life of only 3 hours prevents its clinical application. In search for the ideal corticosteroid preparation, a Dexamethasone Posterior Segment Drug Delivery System (Dexamethasone DDS - Ozurdex®, Allergan Inc, Irvine, California) was recently developed. Promising results have been shown in certain patients with retinal vein occlusions, uveitis receiving this intravitreal drug delivery system with improvement in visual acuity. The present study introduces a novel concept of using Ozurdex ® implant in patients with diabetic macular edema.
Clinical studies and meta-analyses have suggested a link between thyroid dysfunction and lens opacification. The objective of this study is to investigate the causal relationship between hyperthyroidism and the development of cataracts using the Mendelian randomization approach, with the aim of filling the gap in knowledge about the systemic effects of hyperthyroidism on ocular health. Leveraging genetic variants as instrumental variables, the analysis used extensive datasets from the UK Biobank and the FinnGen Database and employed three common approaches for causal inference (the Inverse Variance Weighted method, a regression based method the Weighted Median estimator, and MR-Egger regression) and accompanying sensitivity analyses to ensure robustness. The results demonstrate that there is a strong likely causal relationship, with hyperthyroidism increasing the risk of developing senile cataracts (OR = 361.09, 95%CI 5.024 to 2.60 × 104, P = 0.007). A sensitivity analysis provided no evidence of horizontal pleiotropy and no significant outliers, suggesting the results are robust. In conclusion, our study established a significant causal relationship between hyperthyroidism and increased risk of cataract development, underscoring the importance of considering the systemic effects of hyperthyroidism in clinical and public health interventions and policies. Future research should focus on elucidating the molecular mechanisms underlying this association, exploring the potential benefits of early intervention in hyperthyroidism to prevent cataract development, and investigating whether these findings translate across different ethnic populations. Additionally, further GWAS studies aimed at identifying genetic variants associated with both hyperthyroidism and cataracts are warranted to confirm and expand upon our results.
Raising awareness and improving recognition, accurate classification, and enhanced access to new treatments represent current key challenges for carriers of haemophilia. Women and girls carrying genes for haemophilia often experience significant bleeding and/or low factor levels. The bleeding associated with female haemophilia is frequently overlooked, has a weak correlation with factor levels, and manifests differently than in males, with heavy menstrual bleeding being a predominant symptom. Recent changes in terminology now allow the diagnosis of haemophilia in females with low factor levels and differentiate between symptomatic and asymptomatic carriers of the gene. Observations from real-world experiences and limited clinical trial data have highlighted the positive impact of various new haemophilia treatments for women and girls with clotting factor deficiencies. There is an urgent need for initiatives that increase their access to these treatments and encourage well-designed clinical trials focusing on female-specific outcomes. In women with inherited bleeding disorders, early recognition and optimal management of heavy menstrual bleeding are crucial. However, treatment options and guidance from high-quality clinical trials are currently insufficient. Menstrual health assessment should be a regular part of monitoring women and girls with inherited bleeding disorders throughout their lives, emphasizing the importance of gathering data to improve future management.
Challenges in ensuring adherence to colposcopy and follow-up recommendations, particularly within underserved communities, hinder the delivery of appropriate care. Informed by our established evidence-based program, we sought to assess the feasibility and acceptability of a novel cognitive-affective intervention delivered through a Chatbot interface, aimed to enhance colposcopy adherence within an urban inner-city population. We developed the evidence-based intervention, CervixChat, to address comprehension of colposcopy's purpose, human papillomavirus (HPV) understanding, cancer-related fatalistic beliefs, procedural concerns, and disease progression, offered in both English and Spanish. Females aged 21-65, with colposcopy appointments at an urban OBGYN clinic, were invited to participate. Enrolled patients experienced real-time counseling messages tailored via a Chatbot-driven barriers assessment, dispatched via text one week before their scheduled colposcopy. Cognitive-affective measures were assessed at baseline and through a 1-month follow-up. Participants also engaged in a brief post-intervention satisfaction survey and interview to capture their acceptance and feedback on the intervention. The primary endpoints encompassed study adherence (CervixChat response rate and follow-up survey rate) and self-evaluated intervention acceptability, with predefined feasibility benchmarks of at least 70% adherence and 80% satisfaction. Among 48 eligible women scheduled for colposcopies, 27 (56.3%) agreed, consented, and completed baseline assessments. Participants had an average age of 34 years, with 14 (52%) identifying as non-Hispanic White. Of these, 21 (77.8%) engaged with the CervixChat intervention via mobile phones. Impressively, 26 participants (96.3%) attended their diagnostic colposcopy within the specified timeframe. Moreover, 22 (81.5%) completed the follow-up survey and a brief interview. Barriers assessment revealed notable encodings in the Affect and Values/Goals domains, highlighting concerns and understanding around HPV, as well as its impact on body image and sexual matters. Persistent and relatively high intrusive thoughts and lowered risk perceptions regarding cervical cancer were reported over time, unaffected by the intervention. Post-intervention evaluations documented high satisfaction and perceived usefulness, with recommendations for incorporating additional practical and educational content. Our findings underscore the robust satisfaction and practicality of the CervixChat intervention among a diverse underserved population. Moving forward, our next step involves evaluating the intervention's efficacy through a Sequential Multiple Assignment Randomized Trial (SMART) design. Enhanced by personalized health coaching, we aim to further bolster women's risk perception, address intrusive thoughts, and streamline resources to effectively improve colposcopy screening attendance.
PROBLEM TO BE SOLVED: To markedly enhance the antibacterial action of β-lactam antibiotic substance, particularly against the methicillin resistant Staphylococcus aureus(MRSA) by combining the antibiotic substance with another antibiotic compound bearing the tellimagrandin I skeleton. SOLUTION: (A) A compound bearing the chemical skeleton of tellimagrandin and/or (B) a compound bearing the chemical skeleton of corilagin are used in combination with (C) an antibiotic substance. In a preferred embodiment, the component A is tellimagrandin I, the component B is corilagin and the component C is one or two or more kinds of the β-lactam antibiotic substances. The antibacterial action is preferably the bacteriostatic or bacteriocidal actions against MRSA. The component C is applied usually in a dose of >=1 mg/day/ adult on the solid weight basis. At this time, the components A and B are preferably used in combination in more than the equal amount based on the single dose of the component C in the solid basis.
The present invention discloses an external Chinese medicinal gelling agent and a preparation method thereof. The gelling agent is prepared from effective medicinal ingredients, and an appropriate amount of gel matrix, moisturizing agent and preservative. The effective medicinal ingredients comprise pseudolarix, fructus cnidii, radix stemonae, dandelion, corktree, radix sophorae, dittany, Angelica dahurica and honeysuckle. The preferential gel matrix, moisturizing agent and preservative is carbomer, glycerine and ethyl hydroxyl benzene. The gelling agent has anti-inflammatory, anti-allergic and antipruritic functions, and is used for treating skin diseases caused by hand and foot tinea, tinea cruris, tinea versicolor and fungus. Moreover, the gelling agent has strong adhesive quality in the position with pathological changes, and overcomes the defect of easily volatilizing and losing tincture in the position with the medicine. And the gelling agent has the characteristics of long time of effects, easy coating, excellent coupling effects on the skin, and no stimulus to the mucous membrane of the skin.
The present invention relates to C. elegans insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of C. elegans insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a C. elegans insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a C. elegans gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.
A cancer cell growth suppressor or a cell differentiation inducer is provided which contains as an effective component a water-soluble component of  Capsicum Annuum  L.Var. grossumn  which is a Solanacede plant. It is manufactured by mixing dried powder of fruits of  Capsicum Annuum  L.Var. grossumn  and water for 40 hours or longer while maintaining them at normal temperature or higher, and obtaining an aqueous solution or a water-soluble component by separating the mixture into solid and liquid. A component having cancer cell growth suppressing properties or cell differentiation inducting properties, which could not be extracted sufficiently in a normal, short-time water-soluble component-extracting step, is reliably contained. It is used as a cancer cell growth suppressor or a cell differentiation inducer for treating cancer carriers or preventing recurrence.
The group, not subjected to biophysical therapy, will be controls. Patients will follow standard rehabilitation treatment: patients will perform active and active-assisted ROM recovery exercises and stretching exercises for 30 minutes per day, for 6 weeks.
Patients receive a volar plaster splint with inelastic bandage after the surgery, and are instructed not to remove the immobilization for 2 weeks. After this period, the immobilization is removed and patients begin rehabilitation with physiotherapy.