anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The study aims to investigate the effects and potential mechanisms of lncRNA-MM2P on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). The OIR model was established in C57BL/6J mice. RAW264.7 cell line and bone marrow-derived macrophages (BMDMs) from mice were used for in vitro studies. RT-qPCR was used to analyze the expressions of lncRNA and mRNAs. The protein expression levels were determined by western blotting. The size of avascular areas and neovascular tufts were assessed based on isolectin B4 immunofluorescence staining images. The human retinal endothelial cells (HRECs) were used to evaluate the proliferation, migration, and tube formation of endothelial cells. The expression of lncRNA-MM2P was significantly upregulated from P17 to P25 in OIR retinas. Knockdown of lncRNA-MM2P levels in vivo led to a significant reduction in the neovascular tufts and avascular areas in the retinas of OIR mice. Knockdown of lncRNA-MM2P levels in vitro suppressed the expression of M2 markers in macrophages. Moreover, we found a significant inhibition of avascular areas and neovascular tufts in OIR mice injected intravitreally with M2 macrophages treated by shRNA-MM2P. The cellular functions of proliferation, migration, and tube formation were significantly attenuated in HRECs cultured with a supernatant of shRNA-MM2P-treated M2 macrophages. Our results indicate that lncRNA-MM2P regulates retinal neovascularization by inducing M2 polarization of macrophages in OIR mice. Therefore, lncRNA-MM2P may be a potential molecular target for immunoregulation of retinal neovascularization.
PURPOSE:To provide a means for inhibiting shape collapse, excellent in shape maintenance, small and easy in handling and cheap, by providing a bonding part at a predetermined portion on one or both sides of an elastic synthetic resin-made sheet and plastering a tape with bonding portion on one side onto the surface applied with adhesive where deodorant or fragrance are added. CONSTITUTION:An adhesive or a tape with bonding portion on both sides 4 is applied on the sheet base material 2. On one part or on the whole of the adhesive or the tape, deodorant or fragrance 5 are maintained. The tape having a bonding portion on one side 6 is plastered on it. Incidentally it is possible that either deodorant of fragrance or both of them are maintained over the whole region of the sheet material 2. It is also possible that deodorant and fragrance are maintained at a separate location. The sheet base material 2 is synthetic resin-made sheet with elasticity having a width of 300mum. It has a proper shape such as a rectangle. In the case of small-sized sheet, it has, for example a measurement of 800mm in width, 150mm in length.
Standard of care arm: utilizes the current standard of care per Zambian national guidelines to determine treatment failure and eligibility for second-line ART. HIV-1 viral load measurement is performed if the criteria for either immunologic (i.e., CD4+ lymphocyte count-based) or clinical treatment failure are fulfilled. If both immunologic and clinical treatment failure criteria are fulfilled, the ART regimen is changed to second-line without VL testing.
Colonoscopy is the standard approach for evaluating the colon currently. Thorough bowel cleansing is critical for adequate visualization of colonic mucosa during colonoscopy. Inadequate bowel cleansing results in adverse consequences for the examination, including lower adenoma detection rates, longer procedural time, lower cecal intubation rates, shorter intervals between examinations and an estimated 12-22% increase in overall colonoscopy cost.Unfortunately, despite advances in bowel preparation methods, up to one-third of all colonoscopies are reported to have an inadequate bowel preparation.

The Bristol stool form scale ( BSFS) was developed in 1988 by O'Donnell LJD et al and was widely applied in both gastrointestinal study and clinical practice. BSFS divides human stool into 7 different styles according to its moisture content. In our clinical work, we find that it is prone to gain poor bowel cleansing quality in patients who pass type 1or 2 stool. Unfortunately, there is lacking of study on tailored bowel preparation according to Bristol stool form scale. Thus, we intend to develop an easy, practical, BSFS based tailored bowel cleansing regimen, in order to serve clinical work and research.
OBJECTIVES: I. Compare the anti-tumor efficacy of two treatment schedules of lurtotecan liposome, in terms of clinical/radiological response and CA125 tumor marker, in patients with previously treated advanced or recurrent ovarian epithelial cancer. II. Compare the safety, pharmacokinetics, and possible pharmacokinetic/pharmacodynamic relationships of these treatment schedules in these patients. III. Compare the time to progression in patients treated with these treatment schedules.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to time from last prior chemotherapy (less than 6 months vs 6 months or more) and number of prior chemotherapy regimens (1 vs 2). Patients are randomized to one of two treatment arms. Arm I: Patients receive lurtotecan liposome IV over 30 minutes on days 1-3. Arm II: Patients receive lurtotecan liposome IV over 30 minutes on days 1 and 8. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Patients achieving complete response (CR) receive 2 additional courses after documented CR. Patients achieving partial response (PR) receive 4 additional courses after documented PR or until disease progression at investigator's discretion. Patients with stable disease continue therapy for a maximum of 6 courses. Patients are followed at 4 weeks and then every 3 months until disease relapse or progression.

PROJECTED ACCRUAL: A total of 40-74 patients (20-37 per treatment arm) will be accrued for this study within 10 months.
Hair waving and straightening compositions comprise a sulfite and/or bisulfite reducing system, urea in amount of at least 10% by weight, a cationic polyquaternary having conductivity, when measured at 0.1% by weight concentration, from 225 mhos to 25 mhos, in an amount of at least 0.07% by weight, the composition having a pH in the range of 5.5 to 8.5. the cationic polyquaternary resin in combination with the urea in the reducing system produces a hair waving and/or straightening effect equivalent to conventional thioglycolate systems without the attendant unpleasant odours associated with the thioglycolate systems. The reducing system is less damaging to the hair and skin than the thioglycolate systems. The system may be used either with or without heat such as heat from hair dryers. Such hair waving and straightening compositions may contain any conventional additives employed in the known sulfite and/or bisulfite systems (e.g. wetting agent, fragrance compounds, coloring agents, thickening agents, opacifying agents, sequestering agents, solubilizing agents, conditioning agents, etc.). The compositions are used in conjunction with conventional neutralizing compositions used for conventional hair waving compositions.
PURPOSE:To obtain a new phenanthrene derivative and a salt thereof having inhibitory activity against interleukin-1 and useful as an adjuvant arthritis depressor. CONSTITUTION:A compound shown by formula I [group A-B is group shown by formula II (R' is H or lower alkyl) or formula III (R<2> is H or lower alkanoyl), etc.], such as 3,4,4a,5,8,9,10,10a-octahydro-1,4a-dimethyl-7-(1- methylethyl)-5,8-dioxo-2phenanthrenecarboxylic acid. The compound is obtained by extracting and isolating from Tripterygium wilfordii Hookfil var. regelii Makino or reacting a corresponding compound wherein R<1> is H with an alcohol in a proper inert solvent (e.g. diethyl ether) in the presence of acid catalyst (e.g. aluminum chloride) at room temperature to reflux temperature for 1-72 hours.
OBJECTIVE: This study describes program implementation through a research-restaurant partnership and assesses participant satisfaction, program costs, and percent body weight changes.
METHODS: Participants (n = 60) in a virtual synchronous (n = 43) or virtual asynchronous (n = 17) 12-week plant-based nutrition program received restaurant vouchers. Class satisfaction data were collected weekly. Assessments were completed at baseline, 3 months, and 9 months, along with interviews (n = 13) between 3 and 9 months. The costing approach estimated costs per participant. Interviews were coded using a content analysis and constant comparative method.
RESULTS: Participants rated the intervention favorably. Program costs were $198.63/participant, and participants' willingness to pay postintervention was $101.50 ± $63.90. Participants shared satisfaction with course content, the restaurant partnership, and suggestions for future delivery. No changes in participants' percent body weight were observed between 3 and 9 months (P = 0.98), indicating maintenance of 3-month weight loss.
CONCLUSIONS AND IMPLICATIONS: A research-restaurant partnership successfully implemented a nutrition program and generated positive feedback. With the lifting of coronavirus disease 2019 pandemic restrictions, future research can now test alternative implementation methods (in person vs online) in other restaurants.
In total 112 patients who underwent coronary artery bypass surgery (CABG) subjected to stress CMR examination on two separate occasions with both stressors; dobutamine and adenosine for assessment of myocardial ischemia as result of typical /atypical angina pectoris. The results from dobutamine (namely, detection of wall motion abnormalities) and adenosine stress CMR (namely, detection of perfusion abnormalities) will be compared with the values obtained from the measures of the hemodynamic forces of the LV (i.e., changes in the intraventricular pressures during systole and diastole). The dimensionless root mean square (FRMS) is computed over the entire heartbeat as a measure of the overall force amplitude. In addition, LV global longitudinal strain (GLS) and LV global circumferential strain (GCS) will be measured using a CMR feature tracking techniques. The expected results are as follows: Dobutamine wall motion analysis in combination with perfusion imaging has the highest diagnostic accuracy for the detection of ischemia in patients after bypass surgery and outperforms pure dobutamine wall motion or perfusion analysis and adenosine perfusion. Whereas, perfusion imaging with both stressors reflects the extent of ischemia more precisely than wall motion analysis. Nevertheless, assessment of hemodynamic forces adds to the diagnostic accuracy as well as the prognostic value of stress CMR in post-CABG patients, in whom stress testing with either or both stressors might fail to precisely define myocardial ischemia or reflect an associated subtle cardiac dysfunction.
PURPOSE: Anterior cutaneous nerve entrapment (ACNES) is characterized by neuropathic pain in a predictable, circumscript abdominal area. The diagnostic delay is long, with half of ACNES-affected individuals reporting nausea, bloating, or loss of appetite mimicking visceral disease. The aim of this study was to describe these phenomena and to determine whether treatment could successfully reverse the visceral symptoms.
METHODS: This prospective observational study was conducted between July 2017 and December 2020 at SolviMáx, Center of Excellence for Chronic Abdominal Wall and Groin Pain, Máxima Medical Center, Eindhoven. Adult patients who fulfilled published criteria for ACNES and reported at least one visceral symptom at intake were eligible for the study. A self-developed Visceral Complaints ACNES Score (VICAS) questionnaire that scores several visceral symptoms (minimum 1 point, maximum 9 points) was completed before and after therapy. The success of treatment was defined as at least 50% reduction in pain.
RESULTS: Data from 100 selected patients (86 females) aged 39 ± 5 years were available for analysis. Frequently reported symptoms were abdominal bloating (78%), nausea (66%) and altered defecation (50%). Successful treatment significantly reduced the number of visceral symptoms, with a VICAS before of 3 (range 1-8) and after of 1 (range 0-6) (p < 0.001). A low baseline VICAS was associated with successful treatment outcome (OR 0.738, 95% CI 0.546-0.999).
CONCLUSION: Patients with ACNES may report a variety of visceral symptoms. Successful treatment substantially reduces these visceral symptoms in selected patients.
<P>PROBLEM TO BE SOLVED: To provide a method for extracting a capsular polysaccharide, and an extracted capsular polysaccharide.  <P>SOLUTION: This method for extracting and isolating a large amount of the capsular polysaccharide (CPS) is provided by using a base extraction of cultured supernatant of the bacterial cells of gram negative bacteria and gram positive bacteria. The method is simple, quick and reproducible, and can be utilized for various bacterial strains. Also, the method produces a new CPS characterized by without covalently bonding with an exogenous peptideglycan. The capsular polysaccharide is utilized as a vaccine against bacterial infection.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Excoriation disorder, also known as skin picking, is a chronic repetitive condition that impacts an individual's daily functioning and causes clinically significant distress. Excoriation is estimated to impact between 2-5% of the general population, although some studies have found up to 14% prevalence rates in undergraduate samples. Acceptance-enhanced behavioral training (AEBT), has shown promising results for targeting skin picking symptoms. However, a recent study demonstrated that mental health providers have limited knowledge of skin picking and how to treat it effectively, creating a dearth of available treatment opportunities .

This study aims to address the gap in accessible evidence-based excoriation treatment by examining the efficacy and feasibility of a self-guided, online program based in AEBT. Participants will be recruited from across the United States from August to November 2023, and will be randomized into either the online intervention group or a waitlist control condition. All participants will complete online self-report assessments at baseline, mid-, post-intervention, and 1 month follow-up, and waitlist participants will be provided access to the program once the study is complete. For the primary aim evaluating efficacy, the investigators predict that both primary (skin picking severity) and secondary outcomes (psychological flexibility, well-being, and distress) will be significantly improved in the active treatment condition compared to a waitlist control group. For the secondary aim evaluating feasibility, the investigators predict that participants will report acceptable feasibility as measured through treatment adherence, reports of usability, and program feedback.
PURPOSE:To obtain a stable antipruritic agent, by compounding sodium erythorbate to an external emulsion preparation containing isothipendyl hydrochloride. CONSTITUTION:The objective antipruritic agent can be prepared by compounding (A) an external emulsion preparation containing isothipendyl hydrochloride (e.g. a mixture of 0.2-2.0pts.wt. of isothipendyl hydrochloride, 5-50pts.wt. of higher paraffinic hydrocarbon, 40-65pts.wt. of water and 3-8pts.wt. of nonionis surfactant) with (B) >=0.02wt%, preferably 0.03-0.1wt% sodium erythorbate based on the external preparation, and (C) a proper amount of a pH-conditioner such as NaOH to keep the pH at 7.5-10.0, preferably about 8.0. If necessary, the preparation may be further compounded with <=20pts.wt., preferably about 10pts.wt. of a higher alcohol such as cetyl alcohol to improve the appearance and properties of the preparation. The decomposition of isothipendyl hydrochloride can be suppressed and the discoloration of the antipruritic agent can be prevented by this process.
Objective:To explore efficacy of narrow band imaging(NBI) technique in CO2laser therapy in Early-Stage Glottic cancer. Methods:The clinical data of patients with Early-Stage Glottic cancer who underwent CO2laser vocal cord resection from June 2011 to August 2022 were retrospectively analyzed. Among these, 27 patients who underwent surgery assisted by NBI were assigned to the observation group, while 25 patients who underwent conventional CO2 laser microsurgery with a suspension laryngoscope were assigned to the control group. The differences between the two groups were analyzed in terms of intraoperative frozen pathology results, postoperative recurrence rates, 5-year cumulative disease-free survival rates, complications, and voice recovery. Results:All 52 patients were operated successfully. Temporary tracheostomy and serious complications did not occur during the operation. The postoperative patient's pronunciation was satisfactory. One patient experienced vocal cord adhesion, but there were no severe complications such as breathing difficulties or bleeding, with an overall complication rate of 1.92%. Postoperative follow-up was 1-5 years. The 5 years recurrence free survival in the general group was 77.90%, and the 5 years recurrence free survival in the NBI group was 100%, the difference was statistically significant(P<0.05). NBI endoscopy is safer and more accurate than the general group in determining the safe margin of tumor mucosal resection(P<0.05). Among the patients who accepted the voice analysis, the difference was no statistically significant(P>0.05). Conclusion:Compared with conventional CO2laser surgery under microscope, NBI guided laser resection of Early-Stage Glottic cancer is more accurate. NBI guided laser resection could improve 5 years recurrence free survival rate. In a word, narrow-band imaging endoscopy can has very high value in clinical application.
FIELD: medicine. ^ SUBSTANCE: invention covers lipase crystals cross-linked with a coupling agent able for insolubility-to-solubility transition and release of soluble lipase resulted from changing the pH value of a medium that surrounds said crystal. According to one version of the invention, the cross-linked lipase crystals are able to release the lipase activity at the controlled rate 0.1% to 100% of a crystalline material a day. The cross-linked lipase crystals are grown by the method that involves interaction of lipase crystals with the coupling agent in conditions sufficient to initiate cross-link of crystals. There is also offered lipase delivery system that includes a cross-linked lipase crystal and consists of microparticles, where the cross-linked lipase crystals have the greatest dimension approximately 0.01 to approximately 500 mcm. Herewith the cross-linked lipase crystal forms provide approximately 50% to approximately 90% of lipase weight content. There is offered composition with controlled rate of lipase activity containing the cross-linked lipase crystals and a acceptable carrier or adjuvant. ^ EFFECT: cross-linked lipase crystals in the composition are practically insoluble in storage and are able to release lipase activity in vivo at controlled rate. ^ 30 cl, 9 dwg, 36 tbl, 55 ex
INTRODUCTION: Chronic obstructive lung diseases, such as asthma and COPD, appear to have a more extensive impact on overall functioning than previously believed. The latest data from clinical trials suggests a potential link between cognitive deterioration and chronic obstructive inflammatory lung disease. This raises the question of whether these diseases affect cognitive functions and whether any relevant biomarker may be identified.
METHODS: This prospective observational study included 78 patients divided equally into asthma, COPD, and control groups (n=26, 27 and 25 respectively). The participants underwent identical examinations at the beginning of the study and after at least 12 months. The test battery comprised 16 questionnaires (11 self-rated, 5 observer-rated, assessing cognition and mental state), spirometry, and blood samples taken for PKA and CREB mRNA evaluation.
RESULTS: A 2.3-fold increase in CREB mRNA was observed between examinations (p=0.014) for all participants; no distinctions were observed between the asthma, COPD, and control groups. Pooled, adjusted data revealed a borderline interaction between diagnosis and CREB expression in predicting MMSE (p=0.055) in COPD, CREB expression is also associated with MMSE (β=0.273, p=0.034) like with the other conducted tests (β=0.327, p=0.024) from COPD patients. No correlations were generally found for PKA, although one significant negative correlation was found between the first and second time points in the COPD group (β=-0.4157, p=0.049),.
DISCUSSION: Chronic obstructive lung diseases, such as asthma and COPD, may have some linkage to impairment of cognitive functions. However, the noted rise in CREB mRNA expression might suggest a potential avenue for assessing possible changes in cognition, especially in COPD; such findings may reveal additional transcription factors linked to cognitive decline.
Smoking relapse rates remain high, innovative strategies are needed to lower them, and web-based social networking may help like Twitter. This developmental research examined whether providing virtual (web-based) social support to smokers, through Twitter-enabled interactive peer texting, could help smokers quit and avoid relapses. Twitter is a free social networking and micro-blogging service, one of the most advanced and novel technologies available today that can provide social support to smokers, and it provides free texting to groups. It is global and has many features that are associated with treatment success including interactive, multi-way, live messaging and mobile accessibility, because the messages go instantly to mobile phones and to the web. It can provide an innovative way to reach smokers who might otherwise not seek treatment, and it can be extended to other health domains. From June 2012 through 2014, we conducted a two-condition randomized controlled trial. All participants in this trial (N=160) received 8 weeks of free nicotine patches, referral to the NCI's online Smokefree.gov Quit Guide, and instruction to set a quit date within 1 week of study start. Participants were also randomly assigned at the individual level to one of two conditions: (1) a virtual or online quit-smoking group on Twitter where the group members were instructed to use interactive peer messaging to help them quit and stay quit, or (2) a control group condition where the group members were not given this instruction or a Twitter group. In total, there were 4 Twitter groups and 4 control groups with 20 smokers randomly assigned to each group (i.e., N=80 test, N=80 control). In the Twitter groups, a bot (auto-messenger) posted a daily cessation-related discussion topic in each group, timed to the group's quit date. The primary outcome was self-reported 7-day point prevalence abstinence that was sustained at 7, 30 and 60 days after the quit date. Participants' posts, their virtual and face-to-face social networks, and several other possible mediating and moderating variables were also analyzed.