anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. The better you follow the directions, the less chance you have of getting pregnant. 

Based on the results of clinical studies, about 1 to 5 out of 100 women may get pregnant during the first year they use levonorgestrel and ethinyl estradiol tablets. 

The following chart shows the chance of getting pregnant for women who use different methods of birth control. Each box on the chart contains a list of birth control methods that are similar in effectiveness. The most effective methods are at the top of the chart. The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant.
### Initial Treatment

In the controlled clinical trials of fluoxetine supporting its effectiveness in the treatment of panic disorder, patients were administered fluoxetine doses in the range of 10 to 60 mg/day (see Clinical Trials). Treatment should be initiated with a dose of 10 mg/day. After 1 week, the dose should be increased to 20 mg/day. The most frequently administered dose in the 2 flexible-dose clinical trials was 20 mg/day.

A dose increase may be considered after several weeks if no clinical improvement is observed. Fluoxetine doses above 60 mg/day have not been systematically evaluated in patients with panic disorder.

As with the use of fluoxetine in other indications, a lower or less frequent dosage should be used in patients with hepatic impairment. A lower or less frequent dosage should also be considered for the elderly (see Geriatric Use under PRECAUTIONS), and for patients with concurrent disease or on multiple concomitant medications. Dosage adjustments for renal impairment are not routinely necessary (see Liver Disease and Renal Disease under CLINICAL PHARMACOLOGY, and Use in Patients with Concomitant Illness under PRECAUTIONS).

### Maintenance/Continuation Treatment

While there are no systematic studies that answer the question of how long to continue fluoxetine, panic disorder is a chronic condition and it is reasonable to consider continuation for a responding patient. Nevertheless, patients should be periodically reassessed to determine the need for continued treatment.
The invention relates to a hospital video surveillance system comprising several cameras (2, 3, 4) for acquiring video data for monitoring several patient areas (5, 6, 7). The video data is transmitted from the camera to a display device and is used to determine a physiological characteristic of a patient, wherein the physiological characteristic is a vital sign. Allocating bandwidth for transmitting the video data according to the determined physiological characteristic. Thus, the bandwidth allocation takes into account the physiological state of the patient, which may ensure that sufficient bandwidth is provided for the real need. This is particularly useful if the total bandwidth is limited. Furthermore, since the video data is used to perform several functions, i.e. monitoring several patient areas and determining physiological characteristics, the overall system may be very compact and may require fewer or no additional physiological sensors.
BACKGROUND: The role of main work during the life course in predicting frailty, a typical geriatric syndrome, is still largely unknown. Therefore, with this research, we aimed to investigate the potential association between the main work done during the life with frailty and pre-frailty among participants 60 years and older of the UK Biobank study.
METHODS: Frailty and pre-frailty presence were ascertained using a model including 5 indicators (weakness, slowness, weight loss, low physical activity, and exhaustion); the main employment status was ascertained using self-reported information. The association between frailty and main work was explored using an ordinal logistic regression model and reported as odds ratios (ORs) with their 95 % confidence intervals (CIs).
RESULTS: The final sample comprised a total of 50,447 individuals (mean age: 64.2 years, females: 50.2 %). Individuals with higher qualifications had a reduced risk of frailty (OR = 0.881, 95%CI = 0.83-0.95, p-value<0.001 for pre-frail and OR = 0.681, 95%CI = 0.63-0.73, p-value<0.001 for frail) compared to those with lower qualifications. Moreover, active participation in the workforce, compared to being inactive, emerged as a protective factor from frailty (OR = 0.753, 95%CI = 0.70-0.81, p-value<0.001). The categories of Associate Professional and Technical Occupations exhibited protective effects against both pre-frailty and frailty. Similarly, occupations categorized as Professional and Management demonstrated protective effects against pre-frailty and frailty when compared to Elementary Occupations. Additionally, engagement in Trades and Services occupations, as opposed to Elementary Occupations, appeared to be protective against frailty.
CONCLUSIONS: In this large cross-sectional investigation based on the data of the UK Biobank we found that work during lifetime could be an important factor in determining frailty later in life.
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient’s clinical status [see Overdosage (10)]. Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids.

While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of morphine sulfate suppositories, the risk is greatest during the initiation of therapy or following a dosage increase. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy with and following dosage increases of morphine sulfate suppositories.

To reduce the risk of respiratory depression, proper dosing and titration of morphine sulfate suppositories are essential [see Dosage and Administration (2)]. Overestimating the morphine sulfate suppositories dosage when converting patients from another opioid product can result in a fatal overdose with the first dose.

Accidental exposure of even one dose of morphine sulfate suppositories, especially by children, can result in respiratory depression and death due to an overdose of morphine.
Topical steroids. Triamcinolone Acetonide Acetate and Urea Cream,10g/tube and Calcipotriol Ointment,10g/tube are used alternately. The period of treatment will be 10 weeks.
BACKGROUND: Accurate molecular and clinical stratification of patients with central nervous system (CNS) non-germinomatous germ cell tumors (NGGCTs) remains challenging, impeding the development of personalized therapeutic approaches. Herein, we investigated the translational significance of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) in pediatric NGGCTs to identify characteristic features of CNS NGGCTs and to identify a subset of patients for whom the presence of residual disease is a risk factor and an indicator of shorter progression-free survival (PFS) and overall survival (OS).
METHODS: Medical records of patients with CNS NGGCTs between January 1, 2018 and December 31, 2022 were reviewed retrospectively.
RESULTS: The cohort consisted of 11 male and six female patients. Tumor markers were elevated in four of the five people who underwent surgery. The remaining 12 patients were diagnosed with malignant NGGCTs according to elevated tumor markers. Among them, ctDNA before chemotherapy as well as ctDNA clearance were consistently associated with PFS and OS (p < .05). By setting a ctDNA positivity threshold of 6%, patients with high ctDNA (above the threshold) levels, which had limitation due to the selection based on optimal statistic from the survival analysis, had significantly inferior 5-year PFS and OS compared to those with low levels (below the threshold). ctDNA or ctDNA clearance combined with the presence of residual disease predicted significantly worse OS and PFS (p < .05).
CONCLUSIONS: CSF ctDNA might allow the study of genomic evolution and the characterization of tumors in pediatric NGGCTs. CSF ctDNA analysis may facilitate the clinical management of pediatric NGGCT patients, and aid in designing personalized therapeutic strategies.
In this study it was aimed to examine the changes in mandibular bone after functional treatment by using fractal dimension (FD) and cortical thickness (CT) analysis. The study will perform on 42 mandibular retrognathia cases. The treatment group (T), comprised of 30 cases treated with functional appliance for one year in puberty. The control group (C) consists of 12 patients who had insufficient oral hygiene; didn't take any orthodontic treatment for one year. FD and CT analysis will evaluate for both sides. FD measurements will perform on processus condylar, antigonial notch, and ramus regions in the panoramic radiographs. Paired t-test will apply to analyze all between groups (before (T1) and after treatment (T2), before (C1) and after (C2) control). Also, independent t-test wişll use to determine whether there was any difference between the treatment group (∆T=T2-T1) and the control group (∆C=C2-C1).
The present invention relates to a health care brain-refreshing towel treated by Chinese medicinal solution, and preparation technology thereof, which belongs to the technical field of the manufacture of health care brain-refreshing towels. The present invention solves the problem that the existing brain-refreshing preparations of cooling oil, etc. have serious stimulation to facial skin of people. The present invention has the technical scheme that the health care brain-refreshing towel treated by Chinese medicinal solution is a small kerchief treated and soaked in solution prepared from the pure Chinese medical materials of schizonepeta, red sage roots, radix trichosanthis, ganoderma, lilyturf roots, astragalus roots, uncaria, peppermint leaves, wormwood roots, wild chrysanthemum flowers, tangerine peel, rhizoma corydalis, matrimony vine, schisandra, licorice roots, etc. The technological process mainly comprises the treatment of Chinese medicine immersion, decoction, centrifugation, filtration, small kerchief immersion, refrigeration, sterilization, etc. The health care brain-refreshing towel is extremely beneficial to brain refreshment and health care, has low cost and easy use, is well welcomed by a plurality of teachers and students in schools and persons on a trip and is suitable for mass production and application.
The invention relates to the technical field of veterinary medicine preparation and particularly relates to wettability andrographis paniculata powder and a preparation method thereof. The wettability andrographis paniculata powder which can easily and uniformly disperse in water and is beneficial to administration with water is prepared by adding a suspending agent and a dispersing agent on the basis of an andrographis paniculata effective component through the reasonable medicine proportioning. The wettability andrographis paniculata powder provided by the invention is convenient to use and has a good treatment effect. The survey tests on the curative effect on animals show that the treatment effect of the wettability andrographis paniculata powder on swine pneumonia is obviously superior to that of tilmicosin premix (P is less than 0.05), and the treatment effect of the wettability andrographis paniculata powder on broiler chicken pullorum disease is obviously superior to that of commercially available andrographis paniculata powder (P is less than 0.05). The invention also provides a preparation method of the wettability andrographis paniculata powder. The preparation method is simple in process, low in production cost and suitable for industrial mass production.
PURPOSE:To eliminate or reduce extremely strong bitterness unique to aloe and render the aloe suitable for internal use, by blending powdered aloe with cyclodextrin. CONSTITUTION:1pts.wt. powdered aloe is blended with 0.2-3pts.wt. cyclodextrin and then kneaded with an adequate amount of water. Starch, lactose, etc., if necessary, are added as an extender. The obtained blend is then passed through a screen of a suitable mesh and dried to provide the aimed granular substance. Dried powder prepared by drying juice obtained from leaves of a living body of a plant belonging to the genus Aloe of the family Liliaceae, removing unnecessary parts from the living body of the aloe, freeze-drying and pulverizing the freeze-dried bodies, etc., are used as the powdered aloe. alpha-, beta- and gamma-Cyclodextrin can be used as the cyclodextrin, but the beta-cyclodextrin is preferred since it is inexpensive and appears on the marketed in large amounts. The living body of the aloe is used as a laxative in various fields, e.g. constipation, hemorrhoids, anemia, etc.
PURPOSE:To obtain the title compound useful as an antimicrobial agent inexpensively, safely and in high yield, by protecting amino groups of a raw material compound by a specific method, introducing glycyl to the methyl amino group at the 4-position by a specific method and then deprotecting with an acid. CONSTITUTION:First, a compound shown by formula I (R1 is methoxy, OH, etc.) is treated with a compound shown by formula II (R2 is H, lower alkyl, etc.) preferably in a solvent approximately at room temperature to give a compound shown by formula III. Then the compound is reacted with a carboxylic acid shown by formula IV (R3 and R4 are lower alkyl, lower alkoxy, etc.) or a reactive derivative thereof preferably in the presence of a base to give a compound shown by formula V, which is treated with an acid such as hydrochloric acid to give the aimed compound shown by formula VI. The amount of the compound shown by formula II used is preferably 3 equivalent based on the compound shown by formula I.
PURPOSE: A composition and a cosmetic composition containing Pharbitis Semen extract are provided to effectively prevent and treat pancreatic cancer. CONSTITUTION: A composition for preventing and treating pancreatic cancer contains Pharbitis Semen ethanol extract as an active ingredient, prepared by extracting Pharbitis Semen with 95% ethanol at 50 Deg. C. for 24 hours. The composition also contains pharmaceutically acceptable carriers or diluents. A cosmetic composition containing Pharbitis Semen ethanol extract for pancreatic cancer contains cosmetologically acceptable cosmetic additives. [Reference numerals] (AA) Relative cell survival rate
Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation. Significant deviations from normal concentrations may require tailoring of the electrolyte pattern, in this or an alternative solution(s).

Sodium-containing solutions should be administered with caution to patients receiving corticosteroids or corticotropin, or to other salt-retaining patients. Care should be exercised in administering solutions containing sodium to patients with renal or cardiovascular insufficiency, with or without congestive heart failure, particularly if they are postoperative or elderly. See PRECAUTIONS, Geriatric Use.

To minimize the risk of possible incompatibilities arising from mixing this solution with other additives that may be prescribed, the final infusate should be inspected for cloudiness or precipitation immediately after mixing, prior to administration, and periodically during administration.
Patients should be instructed that prior to initial use of NitroMist Lingual aerosol, the pump must be primed by pressing the actuator button 10 times to ensure proper dose priming. If the product is not used for more than 6 weeks, the bottle can be adequately re-primed with 2 sprays.

NitroMist is meant to be sprayed on or under the tongue at the beginning of angina or to prevent an angina attack. Treatment with nitroglycerin products such as NitroMist may be associated with lightheadedness on standing, especially just after rising from a laying or seated position. This effect may be more frequent in patients who have consumed alcohol, since alcohol use contributes to hypotension. If possible, patients should be seated when taking NitroMist. This reduces the likelihood of falling due to lightheadedness or dizziness [ see DOSAGE AND ADMINISTRATION (2.3)].
This group is asked to do 10 min/day practice of neurofeedback mindfulness for 8 weeks. They should sit comfortably in a quiet area and do one of ten beginner self-guided mindfulness sessions on mind-body scanning techniques from within the MUSE app. Each session includes a brief explanation for 2-3 minutes before the practice. Once the participants start their practices, they receive sounds for their real-time brain activities: thunderstorm for an active state, ocean waves for a neutral state, and birds chirping for a relaxed state. For each five seconds of consistent relaxed state, the participants are reinforced with points.
According to the sequence principle of low and high dose of C-13-60 cell reinfusion, the dose escalation experiment was carried out successively. Three subjects in each dose group were enrolled first. If DLT did not appear, the decision of whether to enter the next dose group was made according to Safety review committee (SRC) resolution. If there was one case of DLT, then 3 subjects were enrolled one by one, and DLT observation was completed for 28 days after each subject's infusion. If no DLT was found, the next infusion was continued. If DLT was found, the subsequent enrollment of the dose group was terminated, and the experiment was terminated or the dose was reduced according to the dose increasing principle. If \> 1 case of DLT occurs, the trial is terminated or the dose is reduced.According to the evaluation of the researchers, the subjects who met the conditions of antisepsis received antisepsis chemotherapy 1-5 to -3 days before the transfusion of C-13-60 cells；
Q-temp-w1 is a contact type body temperature patch developed by Quanta Computer Co., Ltd. It is mainly used to measure the body temperature of the human body. It can be used for general body temperature measurement, home temperature measurement records and medical tracking. Both the European Union and the US FDA state that the clinical test methods of the temperature patch must comply with ISO 80601-2-56. Therefore, this test plan will follow the ISO 80601-2-56 criteria to evaluate the accuracy of the temperature patch and follow it. The sampling age range and the fever/non-fever ratio are stratified, and clinical efficacy analysis is performed based on the measurement results. The main evaluation indicators include clinical bias, limits of agreement, and clinical repeatability.
The logopenic variant of primary progressive aphasia (lvPPA) is characterized mainly by anomia, production of phonological errors, and impairment in repetition of sentences. The functional origin of these language impairments is mainly attributed to the breakdown of phonological short-term memory. The present study examined the effects of phonological short-term memory impairment on language processing in lvPPA. In two studies, 11 participants with lvPPA and 11 healthy control participants were presented with repetition tasks in which the type and length of stimuli and the mode of administration were manipulated. Study 1 aimed to examine the influence of length and lexicality (words vs. pseudowords) on immediate and delayed repetition, whereas Study 2 aimed to examine the influence of length, syntactic complexity (nominalized vs. pronominalized sentences), and serial position on immediate sentence repetition. Study 1 showed that participants' performance with lvPPA was impaired only on immediate repetition of five-syllable pseudowords and on delayed repetition of words and pseudowords. Study 2 showed that participants' performance with lvPPA was impaired in the repetition of nominalized sentences where a recency effect was observed. Repetition of pronominalized sentences was also impaired in the lvPPA group. This study provides additional support for arguments regarding phonological short-term memory as a cause of language impairment in lvPPA. Clinically, the results of the study suggest that instruments for assessing repetition ability in lvPPA should include not only lists of short or long nominalized sentences, but also delayed repetition of words and pseudowords and pronominalized sentences.
Standard of care: Those who test positive in both tests receive post-test counseling, including emotional support, and are linked to a facility for antiretroviral (ART) initiation, ideally within one week. During the 1st medical appointment after diagnosis, lab tests are requested including CD4 and viral load. In most cases, ART initiation occurs at the second medical appointment when safety lab results are available. Currently, it is not mandatory to have CD4/VL results available to start ART. It is recommended that patients have CD4 counts and viral load assessed twice during the first year. A one-month supply of ART is provided initially. If clients are adherent, ART is dispensed every 3 months by nurses who also assess adherence. Standard follow-up is performed by nurses when clients visit the center for their appointments.
This study examines the efficacy of perioperative dose of celecoxib in pain management after hip arthroscopy. Perioperative administration of celecoxib has been shown to improve pain control after knee arthroscopy, but this has not yet been studied in the hip. In this study, patients are randomized to receive either 400mg celecoxib or placebo 1 hour prior to undergoing hip arthroscopy surgery. Postoperatively, patients are monitored for pain on the VAS scale, narcotic use, and meeting discharge criteria. The study will enroll 100 patients. Patients are approached for informed consent on the day of surgery. Pain scores, narcotic use, and time to discharge in the celecoxib group are compared to the placebo group.
Participants in this arm will receive a combination of the language intervention and the behavioral intervention. The interventions will be implemented simultaneously for 18 weeks.
The present invention discloses fishing medicine using a periploca sepium liposoluble component extract as a main component. The present invention has the technical scheme that a root bark and a stem bark of periploca sepium are dried and crushed, and are extracted by using methanol reflux at 60 DEG Cto 70 DEG C of temperature. An extracting solution is concentrated, and methanol is evaporated into the shape of fluid extract. The extracting solution is extracted by alcohol, the extracting solution is concentrated to 10% to 15% of the dry weight of the root bark and the stem bark of the periploca sepium, and the periploca sepium liposoluble component extract is obtained. The fishing medicine using the periploca sepium liposoluble component extract as the main component has components and weight percentage contents that the periploca sepium liposoluble component extract is from 20% to 75%, surface active agent is from 3% to 10%, and solvent is surplus. Compared with chemical medicament, the fishing medicine using the periploca sepium liposoluble component extract as the main component has the advantages of no influence on the quality of aquatic products, no residue, no pollution, no influence on the eating and the growth of the aquatic products, and safety to aquatic animals, etc.; the aquatic products are not easy to generate medicine resistance.