anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: PCORnet, the National Patient-Centered Clinical Research Network, is a large research network of health systems that map clinical data to a standardized data model. In 2018, we expanded existing infrastructure to facilitate use for public health surveillance. We describe benefits and challenges of using PCORnet for surveillance and describe case studies.
METHODS: In 2018, infrastructure enhancements included addition of a table to store patients' residential zip codes and expansion of a modular program to generate population health statistics across conditions. Chronic disease surveillance case studies conducted in 2019 assessed atrial fibrillation (AF) and cirrhosis. In April 2020, PCORnet established an infrastructure to support COVID-19 surveillance with institutions frequently updating their electronic health record data.
RESULTS: By August 2023, 53 PCORnet sites (84%) had a 5-digit zip code available on at least 95% of their patient populations. Among 148,223 newly diagnosed AF patients eligible for oral anticoagulant (OAC) therapy, 43.3% were on any OAC (17.8% warfarin, 28.5% any novel oral anticoagulant) within a year of the AF diagnosis. Among 60,268 patients with cirrhosis (2015-2019), common documented etiologies included unknown (48%), hepatitis C infection (23%), and alcohol use (22%). During October 2022 through December 2023, across 34 institutions, the proportion of COVID-19 patients who were cared for in the inpatient setting was 9.1% among 887,051 adults aged 20 years or older and 6.0% among 139,148 children younger than 20 years.
CONCLUSIONS: PCORnet provides important data that may augment traditional public health surveillance programs across diverse conditions. PCORnet affords longitudinal population health assessments among large catchments of the population with clinical, treatment, and geographic information, with capabilities to deliver rapid information needed during public health emergencies.
PROBLEM TO BE SOLVED: To make an extract of silky fowl hard to deteriorate and cold stored for a long time. SOLUTION: This method uses a basic raw material comprising the meat of silky fowl formulated with Acanthopanax spinosum, jujube, Totyuu (bark of Euonymus tricocarpus), Zingiber siccatum, Glycyrrhiza, Gomisi (fruit of Schizandra chinensis), lycii fructus, Erythrina indica Lam, ginseng and dried orange peel. The extract of the silky fowl is obtained by putting the basic material and water into a sealed vessel, heating at a predetermined temperature and a predetermined time and then compressing with a compressor. The extract of the silky fowl is obtained by adding various Chinese medicine in this case. Accordingly, the extract is free from deterioration and subjected to a cold storage for a long time. This extract promotes blood circulation in the body, actives the metabolism, removes old blood, enhances the heart and vitality and improves physical strength.
OBJECTIVE: Obesity increases deposition of extracellular matrix (ECM) components of cardiac tissue. Since obesity aggregates with insulin resistance and heart disease, it is imperative to determine whether the increased ECM deposition contributes to this disease cluster. The hypotheses tested in this study were that in cardiac tissue of obese mice i) increased deposition of ECM components (collagens and hyaluronan) contributes to cardiac insulin resistance and that a reduction in these components improves cardiac insulin action and ii) reducing excess collagens and hyaluronan mitigates obesity-associated cardiac dysfunction.
METHODS: Genetic and pharmacological approaches that manipulated collagen and hyaluronan contents were employed in obese C57BL/6 mice fed a high fat (HF) diet. Cardiac insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp and cardiac function was measured by pressure-volume loop analysis in vivo.
RESULTS: We demonstrated a tight association between increased ECM deposition with cardiac insulin resistance. Increased collagen deposition by genetic deletion of matrix metalloproteinase 9 (MMP9) exacerbated cardiac insulin resistance and pirfenidone, a clinically available anti-fibrotic medication which inhibits collagen expression, improved cardiac insulin resistance in obese mice. Furthermore, decreased hyaluronan deposition by treatment with PEGylated human recombinant hyaluronidase PH20 (PEGPH20) improved cardiac insulin resistance in obese mice. These relationships corresponded to functional changes in the heart. Both PEGPH20 and pirfenidone treatment in obese mice ameliorated HF diet-induced abnormal myocardial remodelling.
CONCLUSION: Our results provide important new insights into the role of ECM deposition in the pathogenesis of cardiac insulin resistance and associated dysfunction in obesity of distinct mouse models. These findings support the novel therapeutic potential of targeting early cardiac ECM abnormalities in the prevention and treatment of obesity-related cardiovascular complications.
PURPOSE: An anticonvulsant material separated from a Gastrodiae Rhizoma extract having a therapeutic effect on seizure and convulsion is provided. The material is useful in increasing GABA (γ-aminobutyrate) levels in pathological states by reducing immunologic reactivity of GABA-T, SSADH and SSAR. CONSTITUTION: The anticonvulsant material having a therapeutic effect on seizure and convulsion is separated from a Gastrodiae Rhizoma extract. The material is gastrodin and used in increasing GABA levels. The Gastrodiae Rhizoma extract obtained by extracting with ethyl acetate, n-butanol and water and fractioning with n-butanol. A pharmaceutical composition containing the Gastrodiae Rhizoma extract can be used as a therapeutic agent for the treatment of convulsion and its daily dose is about 0.001μg to 100mg per kg body weight per day.
After the purpose of the study was explained and their verbal and written consents were obtained, a questionnaire including the Beck Anxiety Scale, which includes the socio-demographic characteristics, and the World Health Organization Quality of Life Scale, were applied to the patients in the experimental and control groups. will participate in the research, will be asked, and will be filled in face to face by the responsible researcher. After the progressive relaxation exercise training is given to the experimental group patients, the voice recording containing the commands for the application of the progressive relaxation exercise will be sent to the phone of the patient and/or their relatives. Patients in the experimental group spent an average of 25-30 minutes each day for four weeks. Ongoing exercises will be conducted and followed up. At the end of the fourth week, "Beck Anxiety Scale and World Health Organization Quality of Life Scale" will be applied.
Killer cell lectin-like receptor B1 (KLRB1) is implicated in cancer progression and immunity. In this study, we aimed to evaluate the expression levels of KLRB1 in lung adenocarcinoma (LUAD) and analyze the relationship between KLRB1 expression levels, LUAD progression, and the tumor immune microenvironment. KLRB1 levels in LUAD were analyzed using data from the TCGA and XENA databases. Additionally, the diagnostic values of KLRB1 were analyzed in patients with LUAD. Survival and meta-analyses were employed to investigate the relationship between KLRB1 levels and other prognostic factors in patients with LUAD. Bioinformatics and cellular experiments were used to understand the functions and mechanisms of KLRB1. In addition, correlation analysis was used to investigate the relationship between KLRB1 levels and the immune microenvironment in LUAD. Reduced KLRB1 expression in LUAD was found to positively correlate with tumor size, distant metastasis, pathological stage, age, overall survival, diagnostic value, and disease-specific survival in patients with LUAD (P < 0.05). Conversely, increased KLRB1 expression was found to positively correlate with the overall survival and disease-specific survival in patients with LUAD (P < 0.05). We also found that the overexpression of KLRB1 can inhibit the proliferation, migration, and invasion of LUAD cells and promote apoptosis. KLRB1 was involved in immune cell differentiation, NF-kB, PD-L1, and PD-1 checkpoint pathways and others. Additionally, KLRB1 expression was linked to tumor purity, stromal, immune, and estimate scores, the levels of immune cells including B cells, CD8+ T cells, and CD4+ T cells, and immune cell markers in LUAD. Reduced KLRB1 expression has a significant positive correlation with diagnosis, poor prognosis, and immunity to cancer in patients with LUAD. KLRB1 inhibited cell proliferation and migration in patients with LUAD. These results suggest that KLRB1 may serve as a potential therapeutic target in patients with LUAD.
Background and Objective: An increasing number of countries are deciding to regulate the medicinal and/or recreational use of cannabis (Cannabis sativa L.). However, there is a lack of information on the impact of regular consumption of this substance on public health. In this study, for the first time, regular cannabis consumers in Spain were assessed using health indicators, comparing these data with the general population. Methods: Various items of the Enquesta de Salut de Catalunya (ESCA) and other items related to cannabis use were selected to build a survey and administer it to a representative sample of regular cannabis users in Catalonia. Results: Most of the indicators did not show any deterioration in the health of regular cannabis users compared with the general population. It was observed that users suffered from more sleep problems and about 40% of the sample would like to discontinue cannabis use, suggesting a dependence pattern. About 30% of the sample was able to discontinue the use of prescription medications because of cannabis. Social support and sleep problems, and not cannabis use, were predictors of depression and well-being scores. Conclusions: It seems that regular cannabis use, despite contributing to problems related to sleep quality or dependence, does not have a negative impact on public health in a manner detectable using health indicators.
Aiming to recruit 20 participants due to have a COVID vaccine at Southampton General Hospital. We are aiming to recruit 20 healthy volunteers meeting the criteria as per study eligibility.
The control group is standard of opioid anesthesia including reminfentanil and sufentanil. In addition to dexmedetomidine and transverse abdominal plane block, general anesthesia induction will be induced performed with sufentanil (0.5 μg kg-1), propofol (1.5 mg kg-1), and rocuronium (1 mg kg-1). General anesthesia was maintained with a continuous infusion of remifentanil (5-15 μg kg-1 h-1), cisatracurium (0.1-0.2 mg kg-1 h-1), dexmedetomidine (0.4 μg kg-1 h-1), and sevoflurane exposure guided by bispectral index. Dexmedetomidine administration and sevoflurane inhalation will be completed at 20 minutes before surgery finish. Propofol and remifentanil will be continuously infused till the end of surgery.
HIV-infected children typically respond poorer to vaccines as compared to normal children. The FDA has currently approved several Influenza A 2009 monovalent vaccines to be used in children and adults. However, little data is available in perinatally infected youth. Therefore, knowledge of the immunogenicity of several of the licensed Influenza A 2009 monovalent vaccines in HIV-infected children and youth is critically important to address the health care needs of this vulnerable population. Efforts are currently underway to evaluate Influenza A 2009 monovalent vaccines in healthy children as well as other populations. This study will assess the immune response following receipt of three Influenza A monovalent vaccines in HIV-1 infected children and youth. Protection of HIV-1 infected children and youth from 2009 H1N1 Influenza A will require knowledge of immunogenicity of these new products in this population. The 2009 (H1N1) Influenza A virus is likely to infect a significant proportion of HIV-1 infected children and youth. Immunogenicity of licensed and commercially available Influenza A 2009 monovalent vaccines must be established in HIV-1 infected children in order to assure that this population is protected. Lack of a protective immune response would support the need for additional measures to protect this high risk population.
PROBLEM TO BE SOLVED: To obtain a skin preparation for external use having excellent preventing effects on skin aging, reducing effects on skin roughening and humectant effects by including a lignan glycoside and an antiinflammatory agent. SOLUTION: This preparation for external use is obtained by including a lignan glycoside represented by the formula [R is a glycosyl; (n) is 0 or 1] and an antiinflammatory agent such as glycyrrhizic acid, indomethacin, allantoin, guaiazulene, derivatives thereof and salts thereof, zinc oxide, an extract from aloe, an extract from Lithospermi Radix, an extract from Matricaria chachamomille L., an extract from Hypericium erectum Thunb. or an extract from Spindus mukurossi Gaertn. as active indredients. The lignan glycoside is a hydrous lower alcohol extract from a sesame seed, a humidified substance thereof, a germinated substance thereof, a pulverized substance or a defatted substance thereof.  Since efficacies essentially possessed by the pharmacodynamically effective ingredient can sufficiently be manifested, the preparation is effective in preventing the occurrence of a burning sensation due to sunburn, erythema due to irradiation of ultraviolet rays, preventing the occurrence or reducing pigmentation, etc., and is useful for the beauty culture and medicine.
This study on LLLT aims to define the safety and physiologic effects that occur when the human hair follicle and surrounding tissue structures are exposed to this type of radiation. Thus far, all reports on the efficacy of laser light and LED light in this area, have been, in large part, unsupported by multi-center, randomized, double blind, controlled studies. To properly identify the effects in human subjects, exposure to LLLT is not sufficient. The analysis of the non-radiated and radiated tissues is required to elucidate the tissue response and efficacy of the laser therapy. The theory that is widely accepted is that the mitochondria are the powerhouse of the stem cells that cause hair growth. The LLLT "turns on" the nutrient pump process that energizes the mitochondria, which leads to an increase in ATP and subsequent reversal of hair follicles from the dormant stage of growth called telogen, to the active growth stage called anagen.
Ruxolitinib was administered orally twice daily at the starting dose of 5 mg, 15 mg or 20 mg bid based on Baseline platelet counts. The dosage was subsequently adjusted for safety and efficacy so that each patient was titrated to their most appropriate dose.
A device may include a processor. The processor may be configured to receive data during a surgery. The processor may receive data representative of a patient's intraoperative air exchange. The data may represent air exchange for a patient's breath cycle. For example, data may include any of ventilator inlet flow rate, ventilator inlet pressure, ventilator output pressure, chest tube flow rate, or chest tube pressure. The processor may also receive data representative of a surgical parameter other than one related to air exchange. For example, this data may include any of patient medical record data, intraoperative reporting data, surgical procedure data, or the like. The processor may be configured to receive an updated machine learning model from a cloud resource. And the processor may output, during the surgery, information indicative of prolonged-air-leak-likelihood based on data.
Provided in the present invention is an application of a reagent that inhibits the ectopic expression of the PIWIL2 gene and an anti-PIWIL2 gene ectopic expression protein antibody in preparing an anti-tumor drug. Further provided by the present disclosure are an anti-tumor pharmaceutical composition and a method for treating tumors. It has been demonstrated by means of experimentation that treating human or mouse tumor cells by using KAO3 at the time of inoculation may inhibit the generation of tumors in mice. In addition, injecting KAO3 into established lymphoma, breast cancer, lung cancer, and cervical cancer may inhibit tumor growth and prolong the survival of tumor-bearing mice. The inhibitory effect of KAO3 is associated with KAO3-specific antigens expressed on the surface of tumor cells. KAO3 induces tumor cell apoptosis by means of stopping the cell cycle, inhibiting DNA synthesis, and activating a complement during the G2/M phase.
FIELD: medicine, hirudotherapy. SUBSTANCE: the present innovation deals with applying leeches onto tongue. Before this, massage should be carried out by performing pressing genioglossus muscles with hyoid glands, cheek, palatoglossus and palatopharyngeal muscles, superior and middle pharyngeal constrictors. One should perform postisometric relaxation of tongue's muscles followed by pressing hyoid arteries, veins, glossus nerve, glossus branches of glossopharyngeal and vagus nerves. Outside mouth cavity due to pressing followed by postisometric relaxation of masseter muscles one should fulfill pressing of main trunk of glossus artery in Pirogov's triangle and, also, in parotid submaxillary glands with their ducts. When massage is over, one should apply leeches onto tongue's tip, onto area of papillae foliatae, onto superior and inferior surface of tongue and area of hyoid vessels. This enables to remove completely the symptoms characteristic for glossalgia, shorten terms of leeches' application and therapy. EFFECT: higher efficiency of therapy. 2 ex
Pulmonary fibrosis is the outcome of the prolonged interstitial pneumonia, characterized by excessive accumulation of fibroblasts and collagen deposition, leading to its development. This study aimed to study the changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in a rat model of a novel bleomycin-induced pulmonary fibrosis. The findings of our study showed the model was successfully established. The results showed that the alveolar septum in the model was significantly widened and infiltrated by severe inflammatory cells. Alveolar atrophy occurred due to the formation of multiple inflammatory foci. During this period, fibrous tissue was distributed in strips and patches, primarily around the pulmonary interstitium and bronchus. Moreover, lung damage and fibrosis progressively worsened over time. The mRNA expression of HO-1 and NRF2 in the model decreased while the mRNA expression of HIF-1α, VEGF, PI3K and AKT increased. Furthermore, it was observed to decrease the protein expression of E-cad, HO-1 and NRF2, and increase the protein expression of α-SMA and p-AKT. Additionally, this model leaded to an imbalance in the intestinal microbiota. This study demonstrate that the novel pulmonary fibrosis model activates the NRF2/HO-1 pathway and the PI3K/AKT pathway in rat lung tissues, and leading to intestinal barrier disorder.
An embodiment of this disclosure provides a medical dressing. The medical dressing includes a first layer comprising a non-woven material capable of being liquid permeable. The medical dressing also includes a second layer comprising a topical composition and a solidifying agent. The second layer is positioned on a side of the first layer. The medical dressing also includes a third layer comprising a material capable of being liquid impermeable. The third layer is positioned on the second layer opposite the first layer.
Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Acyclovir capsules and tablets are formulations for oral administration.

Each 200 mg capsule contains 200 mg of acyclovir, USP and the inactive ingredients colloidal silicon dioxide, magnesium stearate, pregelatinized starch and sodium lauryl sulfate. In addition, each of the empty gelatin capsules contains gelatin and titanium dioxide and the following colorant agents: FD&C Blue No. 1 and FD&C Red No. 3. The imprinting ink contains the following: black iron oxide, D&C Yellow No. 10 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, FD&C Red No. 40 Aluminum Lake, pharmaceutical glaze and propylene glycol.

Each 800 mg tablet contains 800 mg of acyclovir, USP and the inactive ingredients croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate. 

Each 400 mg tablet contains 400 mg of acyclovir, USP and the inactive ingredients croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.

Acyclovir, USP is a white to off-white, crystalline powder with a molecular formula C8H11N5O3 and a molecular weight of 225. The maximum solubility in water at 37°C is 2.5 mg/mL. The pka’s of acyclovir are 2.27 and 9.25.

The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; it has the following structural formula:
The invention discloses a nano antibody for resisting human EGFR and application thereof. The nano antibody is aEG2C7 nano antibody with the amino acid sequence shown as SEQ ID NO. 2; or an antibody formed by combining aEG2C7 nano antibody with an amino acid sequence shown as SEQ ID NO. 2, aEG1B4 nano antibody with an amino acid sequence shown as SEQ ID NO.1, aEG2E12 nano antibody with an amino acid sequence shown as SEQ ID NO. 3, aEG4D9 nano antibody with an amino acid sequence shown as SEQ ID NO. 4 and aEG6B2 nano antibody with an amino acid sequence shown as SEQ ID NO. 5. The nano antibody has the advantages of high affinity, specificity and low immunogenicity, better stability, simple structure, easy engineering modification and the like, and can be better applied to the development of antibody drugs.
The invention discloses a traditional Chinese medicine composition for promoting wound healing, a film coating agent, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-7 parts of vervain, 1-5 parts of goosegrass, and 0.5-4 parts of fingernail. The traditional Chinese medicine composition is prepared from vervain, goosegrass herb and fingernail according to a specific proportion, has synergistic effect among the three medicines, and has antibacterial effect on escherichia coli and staphylococcus aureus. The 75% alcohol extract of the three medicines has remarkable antibacterial effect on escherichia coli and staphylococcus aureus. The invention plays roles of resisting bacteria, diminishing inflammation, detumescence, hemostasis and analgesia. The film coating agent has good film forming property, flexibility, proper viscosity, good stability, strong adhesion to skin, no irritation and no incompatibility with prescription drugs. The use is safe, the medicine is easy to form a film, the film forming time is short, and the medicine is not easy to fall off.