anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The disclosure relates to the discovery that certain cerebrovascular disorders in humans who exhibit seemingly normal intracranial pressure (ICP) and do not exhibit hydrocephalus can be alleviated or prevented by reducing ICP in the human. Disorders of this type are herein designated normotensive, nonhydrocephalus tenso-responsive cerebrovascular disorder (NNTCDs). The disclosure describes methods of relieving head pain and other symptoms of NNTCDs, for example by withdrawing cerebrospinal fluid (CSF) from the subarachnoid space of a human or by administering a pharmaceutical agent that modulates CSF production, uptake, or both. Methods of assessing whether a human is afflicted with one or more NNTCDs are also described. The disclosure describes numerous pharmaceutical compositions suitable for administration to humans afflicted with NNTCDs to alleviate or prevent such disorders. Such compositions can, for example, include both a CSF-reducing agent and a symptomatic (e.g., head pain) relief agent.
Obesity stands as a significant risk factor for type 2 diabetes, hyperlipidemia, and cardiovascular diseases, intertwining increased inflammation and decreased adipogenesis with metabolic disorders. Studies have highlighted the correlation between Caspase-1 and inflammation in obesity, elucidating its essential role in the biological functions of adipose tissue. However, the impact of Caspase-1 on adipogenesis and the underlying mechanisms remain largely elusive. In our study, we observed a positive correlation between Caspase-1 expression and obesity and its association with adipogenesis. In vivo experiments revealed that, under normal diet conditions, Caspase-1 deficiency improved glucose homeostasis, stimulated subcutaneous adipose tissue expansion, and enhanced adipogenesis. Furthermore, our findings indicate that Caspase-1 deficiency promotes the expression of autophagy-related proteins and inhibits autophagy with 3-MA or CQ blocked Caspase-1 deficiency-induced adipogenesis in vitro. Notably, Caspase-1 deficiency promotes adipogenesis via Atg7-mediated autophagy activation. In addition, Caspase-1 deficiency resisted against high-fat diet-induced obesity and glucose intolerance. Our study proposes the downregulation of Caspase-1 as a promising strategy for mitigating obesity and its associated metabolic disorders.
Data collected will be utilized to perform a retrospective chart review to include measure outcomes and de-identified demographic information detailed in the attached case report forms. In each case where a diagnosis of bipolar disorder I, bipolar disorder II, or bipolar disorder NOS is determined, the child/adolescent will be added to the PBR and provided with information about local providers that are qualified to treat their diagnosis. Each subject can elect to be notified about future research studies s/he may qualify for. Furthermore, the investigators will provide ongoing newsletters with useful information that addresses the latest research underway in the field with the families. If requested, the investigators will provide a written report to their current provider detailing our evaluation. The potential for a breach in confidentiality always exists; however, information that is obtained will be stored in password a protected database and locked file drawers in locked offices; data will have identifying information sheered from it to prevent loss of confidentiality, and all staff must sign confidentiality certificates. If child abuse is detected, the research team is obligated to follow mandatory state reporting laws. To the investigators' knowledge, there is no registry for Pediatric Bipolar Disorder in the city of Houston or the state of Texas that provides the comprehensive evaluation that we are proposing for these children and adolescents and their families. Therefore, this will be a novel service within this division that will provide research to families and potential clients for providers managing these families across the State of Texas.
The present invention provides an external remedy for relieving pain and eliminating inflammation, which is prepared from the raw materials in weight proportions: 100 to 160 portions of kusnezoff monkshood root, 40 to 90 portions of pedate pinallia jackinthepulpit rhizome, 40 to 80 portions of safflower, 30 to 70 portions of acutangular anisodus root, 20 to 50 portions of redroot gromwell root, 10 to 50 portions of benzoin and 10 to 20 portions of remote lemongrass herb. Since many Chinese drugs are used in the external remedy, the external remedy has the functions for activating blood circulation to dissipate blood stasis, dredging channels and relieving pains, and has obvious therapeutic effect on partial sprains, traumatic injuries and pain in joints, muscles, fascias, etc. The external remedy is used for partially external application, and the drug potency can directly reach the affected parts. The present invention has certain antibacterial actions on 18 kinds of bacteria, such as streptococcus, pneumococcus, staphylococcus aureus, etc. Meanwhile, the external remedy has the effects of skin nourishment, skin permeation, fast absorption, manifestation and root cause of disease treatment, etc. The external remedy also has favorable therapeutic effect on skin diseases.
Dentoxol® is a proprietary mouthrinse that has anti-inflammatory, antimicrobial and analgesic effects. Subjects will use Dentoxol® mouthrinse 5 times each day, starting on the first day of radiation therapy and ending on the last day of radiation therapy.
BACKGROUND: Yellow (stripe) rust of wheat, caused by Puccinia striiformis, is a serious disease that results in great economic losses. This study aimed to investigate the variation in plant responses in three wheat cultivars with different resistance levels against yellow rust.
RESULTS: The highest disease severity was recorded for cv. Gemmieza-11 (95%), followed by cv. Shandweel 1 (60%), while the lowest was recorded for cv. Misr-3 (3%). qPCR results of the yellow rust-resistance genes Yr5, Yr10, Yr15, and Yr18 showed that the infection did not affect the expression of Yr5 and Yr15 in the infected Gemmieza-11 plants when compared to the non-infected control. In contrast, the infection significantly overexpressed Yr5 and Yr15 in cvs. Shandweel 1 and Misr-3. However, Misr-3 was superior in this regard, recording 3.85- and 4.07-fold for Yr5 and Yr15, respectively. In addition, the infection significantly upregulated Yr10 and Yr18 in the three tested cultivars, with the superiority for the cultivar Misr-3, followed by Shandweel 1. Activity of the antioxidant enzymes peroxidase, polyphenol oxidase, and catalase was significantly higher in the infected plants of cv. Misr-3 than in cv. Shandweel-1, while the lowest values were recorded in cv. Gemmieza-11. The increment in this activity was associated with a reduction in the lipid peroxidation in the three tested cultivars. The phenolic content considerably increased also upon infection in cv. Misr-3 followed by Shandweel-1 but not in cv. Gemmieza-11, compared to the non-infected plants. Transmission electron microscopy demonstrated that the infected mesophyll cells in cv. Gemmieza-11 showed abnormalities in the chloroplasts and thick-walled haustoria. On the contrary, the mesophyll cells in cv. Misr-3 showed no haustoria and well organized chloroplasts. The mesophyll cells in cv. Shandweel-1 displayed highly degenerated haustoria, a degenerated granulated cytoplasm, and a thick host cell wall, indicating intermediate defense responses against the invading pathogen. Plant growth, yield, and photosynthetic pigments were higher in cv. Misr-3, followed by cv. Shandweel-1, and the lowest values were recorded in cv. Gemmieza-11.
CONCLUSIONS: The obtained results displayed that Yr5 and Yr15 were more effective than Yr10 and Yr18, indicating their main roles in regulating multiple defense mechanisms and hypersensitive responses.
The invention discloses a medicine for treating AIDS, and relates to a traditional Chinese medicine. The medicine is characterized by being made from the following raw materials: 15-25g of angelica, 25-35g of astragalus root, 25-35g of morinda root, 15-25g of red sage root and 1-15g of cassia. The following bulk drugs can also be added: spatholobus stem, pepper, largehead atractylodes, achyranthes root, black bean, pilose asiabell root, sheep manure, clematis root, dried ginger, fibrous root of fistular onion, fly larval and the like. The medicine is prepared by the following steps: taking the raw materials, soaking for 30-40m, adding 700-1000g of water, decocting with slow fire for 15-25m after boiling, and separating dregs from the decoction for oral administration; and baking and grinding the dregs into powder for oral administration. The medicine has the efficacies of invigorating spleen and stomach, invigorating vital energy and producing saliva, recuperating internal organs, nourishing blood and liver, promoting blood circulation to clear channels, enriching the blood and strengthening the bone, and killing viruses. The medicine is used for treating AIDS and has the curative ratio up to 97.7%, and can be also widely applied to treating diseases such as leukemia, aplastic anemia, thrombocytopenia, hepatitis, dermatosis and the like.
Inflammasomes are multimeric protein complexes, sensors of intracellular danger signals, and crucial components of the innate immune system, with the NLRP3 inflammasome being the best characterized among them. The increasing scientific interest in the mechanisms interconnecting inflammation and tumorigenesis has led to the study of the NLRP3 inflammasome in the setting of various neoplasms. Despite a plethora of data regarding solid tumors, NLRP3 inflammasome's implication in the pathogenesis of hematological malignancies only recently gained attention. In this review, we investigate its role in normal lymphopoiesis and lymphomagenesis. Considering that lymphomas comprise a heterogeneous group of hematologic neoplasms, both tumor-promoting and tumor-suppressing properties were attributed to the NLRP3 inflammasome, affecting neoplastic cells and immune cells in the tumor microenvironment. NLRP3 inflammasome-related proteins were associated with disease characteristics, response to treatment, and prognosis. Few studies assess the efficacy of NLRP3 inflammasome therapeutic targeting with encouraging results, though most are still at the preclinical level. Further understanding of the mechanisms regulating NLRP3 inflammasome activation during lymphoma development and progression can contribute to the investigation of novel treatment approaches to cover unmet needs in lymphoma therapeutics.
The purpose of this study is to conduct an observational assessment of natural outcomes within the DSCP, "Quit at Duke." This is an observational study (n=3000) on patients being treated at the DSCP. No interventions are conducted, and data analyzed is collected in the course of clinical care at clinic visits to the Duke Smoking Cessation Program (DSCP). Phone calls are also conducted to determine response to medications and abstinence status up to 12 months following a quit attempt. Outcomes of variables including: demographic variables, evaluation responses, feasibility data, and abstinence rates will be analyzed using general regression models using an ANOVA-based design. Because no intervention is being conducted, there are no safety concerns related to the study.
Group A: whole body vibration therapy group This group will be provided with whole body vibration therapy in spastic cerebral palsy children. Exercise will be conducted 3 times a week for 8 weeks. Pre and post session functional mobility and balance will be measured by pediatric balance scale and time up and go test. Along routine physical therapy such as stretching exercise of achilles tendon, hamstring muscles, hip flexors and adductors, shoulder internal rotators, and wrist flexors, pronators, and ulnar deviator etc.

Group B: BOSU ball training group This group will be provided with both sides up ball BOSU training in spastic cerebral palsy children. Exercise will be conducted 3 times a week for 8 weeks. Pre and post session functional mobility and balance will be measured by pediatric balance scale and time up and go test. Along routine physical therapy such as stretching exercise of achilles tendon, hamstring muscles, hip flexors and adductors, shoulder internal rotators, and wrist flexors, pronators, and ulnar deviator etc.
Ultrasound guided Subcostal transversus abdominis plane block is performed after anesthesia induction and endotracheal intubation , to the side where kidney stone is. A composition of 10 ml Lidocaine %1 plus 10 ml physiologic saline solution plus 10 ml Bupivacaine %0,25 , total of 30 ml of local anesthetic mixture is administered into the area between internal oblique muscle fascia and transversus abdominis muscle fascia. After that, the patient is positioned to lithotomy position and the open-end catheter is inserted. After that the patient is turned to prone position and the percutaneous nephrolithotomy is performed. Tramadol 100 mg iv is administrated 20 minutes before the end of the surgery. Morphine patient controlled analgesia is planned for postoperative pain management.
Compounds of the formula <FORM:1056313/C2/1> (wherein R is H or Me and each of R1 and R2 is H or C1- 5 alkyl) are prepared by reacting the appropriate 3-pyridine sulphonic acid with phosphorus pentachloride to form a 3-pyridine sulphonyl chloride, which is then reacted with ammonia or a suitable amine to form the appropriate sulphonamide.  The products form salts with acids and with bases.ALSO:Anti-coccidial compositions comprise compounds having the formula: <FORM:1056313/A5-A6/1> where R is H or Me, and each of R1 and R2 is H or C1-5 alkyl, or a non-toxic salt thereof, dispersed in animal feeds or feed supplements.  For addition to the drinking water of poultry, the anti-coccidial compounds may be admixed with a suitable carrier or diluent to form a water-dispersible powder. One or more other anticoccidial compounds primarily effective against E. tenella, e.g. 2-methyl-3,5-dinitrobenzamide, nicarbazin, glycarbylamide, 3,5-dinitrobenzamide, methiotriazamine-bithionol mixtures, 1-(2-C1-5 alkyl-4-amino-5-pyrimidinylmethyl)-2-methyl pyridinium quarternary salts such as amprolium, and 1-(2-C1-5 alkyl-4-amino-5-pyrimidinylmethyl)-4-methyl pyridinium quarternary sals such as 1-(2-n-propyl-4-amino-5-pyrimidinylmethyl)-4-methyl pyridinium chloride hydrochloride, may be added to the 3-pyridine sulphonamide compositions.  Coccidiostats active against E. maxima, e.g. compounds of the formula:  <FORM:1056313/A5-A6/2> wherein Y is H, a hydrocarbon radical having fewer than 9 carbon atoms or an equivalent of a metal, X is O or S, R is C1-5 alkyl or alkenyl, and A is an amino or alkylamino radical (including hydroxy-substituted and halogen-substituted alkylamino) or a radical that is convertable thereto by heating with 6N HCl for not more than 3-4 hours, e.g. acylamino, may be added to the compositions containing a 3-pyridine sulphonamide and a coccidiostat effective against E. tenella.
Objective: This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.

Methods: We conduct a quasi-experimental study to measure frailty, depressive symptoms, and quality of life before and after intervention. A total of 120 community-living older adults with frailty identified by Fried's phenotype method are assigned to four groups: physical exercise group, nutrition supplements group, physical exercise and nutrition supplements group, and control group. Each participants in the assigned group will receive 12 weeks intervention. Measurements include frailty (Fried's phenotype method), depressive symptoms (Geriatric Depression Scale-15, GDS-15), and quality of life (WHOQOL-BREF). Data analyses include describe statistics, Chi-square test, and Analysis of Variance. A Generalized estimating equations (GEE) will be used to examine the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life.
Intraoperative fluid management includes Volulyte® (6% hydroxyethyl starch {HES} 130/0.4 in balanced solution) as the only colloid solution to be used, the daily dosage of Volulyte® is restricted to 50 ml/kg. Intraoperative anesthesia and postoperative analgesia will follow the established practice of the individual institution.
Acute Coronary Syndrome Patients With Multi-Vessel Disease. The Residual SYNTAX score (rSS) and the SYNTAX Revascularization Index (SRI) will be calculated in this group and its relationship with patient outcomes either in hospital or in 6 months to 1 year follow-up will be evaluated.
The RICHH intervention is an educational-behavioral and counseling intervention that promotes caregivers' knowledge, skills and motivation to engage in CVD risk reduction. The intervention is delivered individually to caregivers in their homes using video-conferencing technology on mini-iPads that we provide for all participants. Participants keep the mini-iPads at the end of the study. The program consists of 12 weekly sessions \[30-45 minutes\] followed by 8 bi-weekly \[every other week\] booster sessions and 6 monthly booster sessions that will be held at the caregivers' preferred times using a video conferencing program. A cardiac psychiatric advanced practice nurse certified cognitive behavioral therapy will deliver the intervention.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology, and can be used to predict the status of the epidermal growth factor receptor Her2/neu in a primary tumour in patients with breast cancer. At the stage of diagnostics morphological and immunohistochemical examination with determination of histological type of breast cancer and its molecular characteristics are performed after sampling of biopsy material. Thereafter, 2 hours after administration of the preparation "99mTc - DARPin9_29", single-photon emission computed tomography (SPECT) of the chest is performed, at which the labelled protein accumulation is assessed in the breast tumour and the symmetrical section of the opposite breast (background) and the tumour/background ratio is determined. Value of the regression equation Y is calculated by the formula: Y = -85.93 + 56.69 * X1, where -85.93 is the value of the regression coefficient of the free member; X1 is the tumour/background ratio in 2 hours after administration of the preparation "99mTc-DARPin9_29"; X1 = 1 with tumour/background ratio less than or equal to 7.95; X1 = 2 with a tumour/background ratio of more than 7.95; 56.69 is the value of the regression coefficient of this feature. Probability P is determined by formula: P = eY/ (1 + eY), where is a mathematical constant equal to 2.72. If P is more than or equal to 50%, a high probability of the Her2-positive tissue status of the primary tumour node is predicted, while P is less than 50%.EFFECT: method enables accurate and informative prediction of the Her2/neu epidermal growth factor receptor status in primary tumours in patients with breast cancer due to a complex of studies: morphological, immunohistochemical and radiobiological, in which accumulation of preparation "99mTc - DARPin9_29" in breast tumour is assessed by SPECT of chest organs.1 cl, 2 dwg, 3 ex
To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy.

Urinary Tract Infections: For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris. It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination. 

Acute Otitis Media: For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician sulfamethoxazole and trimethoprim offers some advantage over the use of other antimicrobial agents. To date, there are limited data on the safety of repeated use of sulfamethoxazole and trimethoprim in pediatric patients under two years of age. Sulfamethoxazole and trimethoprim is not indicated for prophylactic or prolonged administration in otitis media at any age. 

Acute Exacerbations of Chronic Bronchitis in Adults: For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when a physician deems that sulfamethoxazole and trimethoprim could offer some advantage over the use of a single antimicrobial agent. 

Shigellosis: For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated. 

Pneumocystis jiroveci Pneumonia: For the treatment of documented Pneumocystis jiroveci pneumonia and for prophylaxis against P. jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P. jiroveci pneumonia. 

Traveler's Diarrhea in Adults: For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E. coli.
Verofilcon A contact lens in the right eye (OD), with etafilcon A contact lens in the left eye (OS), as randomized. Lenses will be worn for one day, approximately 8 hours.
The purpose of this research is to test the hypotheses that: 1.) Moderately malnourished stunted children have low pancreatic α-amylase activity; and 2.) Modified starchy food preparations will have better (higher) digestibility than the commonly given foods for both moderately malnourished stunted and healthy non-stunted children. A noninvasive breath test was used to assess amylase insufficiency in moderately malnourished and stunted children in Mali, as well as in healthy children in Mali and the United States. Moderately malnourished and healthy children in Mali were fed sorghum porridges, which are commonly consumed in Mali. Porridges contained a 13C-labeled substrate (algal starch or octanoic acid) for assessment of amylase insufficiency and gastric emptying rate. In a follow-up study, healthy children in the United States were also assessed for amylase sufficiency.
Physiotherapy and rehabilitation treatment program will be applied to the patients. In this program, a 30-40-minute exercise protocol including proprioceptive, balance and strengthening exercises will be applied.