anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a skin external agent highly improved in the stability of the α-tocopheryl retinoate therein, formulated with an α-tocopheryl retinoate and specific hydroquinone glycoside (s). CONSTITUTION: This skin external agent contains pref. 0.0001-10 (esp. 0.01-2.0)wt.% of an α-tocopheryl retinoate useful for preventing or treating keratosis, etc., and preventing or remedying skin aging and pref. 0.001-10wt.% of at least one kind of hydroquinone glycoside of the formula (R is a pentose residue, amino sugar residue, uronic acid residue, or methylated product thereof). The most pref. hydroquinone glycoside is hydroquinone-β-D-glucose (common name: arbutin). The most pref. α-tocopheryl retinoate is the ester of DL-α- tocopherol and all-trans-retinoic acid.
The invention relates to the field of traditional Chinese medicine grading treatment, in particular to traditional Chinese medicine grading treatment equipment and a traditional Chinese medicine grading treatment method. The Chinese medicine grading treatment equipment is mainly suitable for the pretreatment of the white paeony root, the dahurian angelica root and the tree peony bark. It includes control system, delivery track, along traditional chinese medicine direction of delivery set gradually material feeding unit, wash drying device, section device and hierarchical detection device. The purging and drying device, the slicing device and the grading detection device are all arranged on the conveying track. The control system is in communication connection with the conveying track, the purging and drying device, the slicing device and the grading detection device. The equipment can realize full-automatic cleaning, drying, slicing and grading, and reduce the time and the procedure for grading the subsequent medicinal materials. The method saves manpower and material resources, can perform grading treatment on the traditional Chinese medicine in a short time, and saves production cost.
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. The 5-year overall survival rates of childhood osteosarcoma survivors have been increasing substantially with a percentage approaching to 70%. Regrettably, the improved survival rates may lead to long-term sequelae related to disease and treatments that can negatively affect survivors' physical and psychological well-being. Despite numerous studies have examined the impact of cancer and treatment-related late effects on the physical and psychological aspects of osteosarcoma survivors in the foreign countries, it has not been studied specifically in Hong Kong Chinese population. Problems arise when there is a difference in perception and recognition of psychological problems and emotional well-being between Western and Chinese culture. Moreover, the difference in coping strategies between Chinese and Western children also affects how they react and cope with the devastating effect from cancer and its treatments. Due to the cultural and belief differences, the findings from those studies in the foreign counties may not be applicable and transferable in Hong Kong context. There is thus an imperative need to investigate the impact of cancer and treatment-related effects on the physical and psychosocial well-being and quality of life among Hong Kong Chinese survivors of childhood osteosarcoma in order to raise awareness of the holistic wellness of osteosarcoma survivors.
This virtual intervention will include weekly group exercise sessions with a Vivo trainer (2 times/week), weekly health education classes with a registered dietitian (RD) (1 time/week), and two individual meetings with the RD over the course of 12 weeks. Participants will also be asked to complete a weekly aerobic exercise session on their own (1 time/week).
PURPOSE: A porous puff for cosmetics and cosmetic composition dipped in the same are provided to have excellent physical property which can uniformly exhaust the cosmetic composition. CONSTITUTION: A porous puff for cosmetics has the density of 20-50 kg/m. The porous puff for cosmetics is in an open cell structure having the pore size of 20-100ppi. The porous puff for cosmetics has the elasticity of 20-50%. The cosmetic composition is dipped into the porous puff for cosmetics having the density of 20-50 kg/m. The cosmetic composition includes 0.5-5 wt% of silicon elastomer gel ingredient. The silicon elastomer gel ingredient is cyclopenta chamber furnace acid/poly-silicon -11/dimethicone, dimethicone/vinyl dimethicone crosspolymer or vinyl dimethicone/lauryl dimethicone-cross-polymer/squalene. The cosmetics composition comprises 30-50 wt% of aqueous composition, 1-5weight% of emulsifier, 20-50 weight% of oily ingredient, 1-20 weight% of pigment and 5-30 weight% of UV blocking agent. The cosmetics composition has the viscosity of 3000-12000 cps.
Patients receive OCP comprising ethinyl estradiol and norgestrel once daily on days 1-21. Treatment repeats every 28 days for 3-4 courses (3-4 packs of OCP) in the absence of unacceptable toxicity. Approximately 1 week after starting the fourth pack of OCP, patients undergo a repeat transvaginal ultrasound and endometrial biopsy.
An apparatus and method for measuring the key elements of human primary health is disclosed. The apparatus is in the form of a medical diagnostics unit capable of measuring Electrocardiogram (ECG), height, weight, body mass index (BMI), body temperature, hearing efficiency, lung function, pulse, blood oxygen levels, blood pressure, urology and vision testing. The medical diagnostics unit includes an enclosure with a data card and/or fingerprint entry. The enclosure includes medical measuring devices which allow a patient to follow instructions on a touch screen visual display unit to conduct the desired tests and obtain the patient's health information. This information is stored locally as well as being transmitted to a doctor for review and evaluation. The automated medical diagnostics unit reduces the staffing requirements to obtain a patient's basic health information.
Pediatric obsessive-compulsive disorder (OCD) is a common, chronic, and severe psychiatric disorder. Currently, many youth with OCD are treated with medication, such as a serotonin reuptake inhibitor (SRI); however, only a subset of them responds to SRI. Data show that the addition of cognitive-behavioral therapy (CBT) to SRI partial responders is effective although extended SRI use with CBT can attenuate combined treatment outcomes. This placebo-controlled study will enroll pediatric OCD patients to examine if those who benefit from CBT augmentation can discontinue their SRI successfully without relapse over 24-weeks. This study will also bank genomic samples for future analysis when polygenic risk scores for OCD may become available.

This study will be conducted in two phases. In Phase I, all participants will receive a web-based CBT for 12 to 18 weeks. At the end of Phase I, those who achieve wellness indicated by CY-BOCS ≤ 12 and ≥ 50% reduction since baseline for 3 consecutive weeks, will go on to the next phase. In Phase II, participants will be randomized into two groups: 1) Continued SRI and 2) Discontinuation titration to placebo. In this phase, all participants will receive web-based CBT maintenance sessions and attend medication visits for 24 weeks. At 12 months after the end of Phase II, all participants will complete a follow-up assessment.
The hormones of the corpus luteum are obtained in crystalline form by causing crude preparations thereof to react with reagents for the carbonyl group, separating the reaction products, and decomposing them to liberate the hormones.  Reagents specified are bisulphite, hydroxylamine or hydrazine or derivatives thereof, such as semi-carbazide and phenyl-hydrazine sulphonic acid. According to examples; (1) an extract of corpus luteum prepared according to Specification 426,166, [Group VI], is dissolved in alcohol and treated with an aqueous solution of semi-carbazide hydrochloride and sodium acetate, the crude precipitate is washed with alcohol, dissolved in glacial acetic acid, and heated with dilute sulphuric acid, and the reaction mixture extracted with ether to yield the hormone; (2) a corpus luteum preparation is reacted in alcoholic solution with hydroxylamine hydrochloride and sodium acetate, and the oil which separates is washed with water, dissolved in hot methyl alcohol, and water is added to precipitate the oxime which is then boiled with hydrochloric acid to liberate the hormone; (3) an ether solution of a hormone preparation is shaken with an aqueous solution of sodium bisulphite and the aqueous layer is separated and heated with sulphuric acid and the released hormone extracted with ether; (4) a preparation of corpus luteum is dissolved in ethyl acetate, the active constituents are adsorbed on animal charcoal from this solution, extracted from the adsorbate with a mixture of methyl alcohol and chloroform, and boiled with an alcoholic solution of phenyl-hydrazine-4-sulphonic acid; the reaction mixture is distilled to remove the alcohol, extracted with ether to remove inactive products, and the aqueous portion treated with sulphuric acid and extracted with ether to obtain the liberated hormone. Specification 391,686, [Group VI], also is referred to.  The Specification as open to inspection under Sect. 91 states that the crystalline hormones are diketones and may be further purified by recrystallization, by further reaction with a carbonyl reagent such as hydroxylamine, or by sublimation in a high vacuum; refers to recrystallization of the oxime obtained according to example 1, whereby a dioxime of m.p. 240 DEG  C. is obtained which can be separated by further recrystallization into two dioximes of higher melting points leaving a mother liquor which on saponification yields an oxyketone; and includes an additional example according to which an extract of corpus luteum is dissolved in methyl alcohol and boiled with phenyl hydrazine or para-nitrophenyl hydrazine and glacial acetic acid, and the reactive product diluted with water to precipitate a crude hydrazone which is recrystallized from ethyl-or methyl-alcohol and then decomposed with dilute acid.  This subject matter does not appear in the Specification as accepted.ALSO:A preparation of corpus luteum hormone dissolved in ethyl acetate is treated with animal charcoal to adsorb the active constituents which are then extracted from the adsorbate by means of a mixture of methyl alcohol and chloroform.
Youth randomized into the YRI+Entrepreneurship Training arm will begin the YRI module within two weeks after the completion of baseline assessments. The YRI curriculum (12 modules), will be delivered in 12 weekly 90-minute sessions, with additional time taken as needed. These weekly sessions assume a peer-to-peer group learning format deemed culturally appropriate for a setting like Sierra Leone where limited resources for mental health services exist. Once youth complete the YRI they will complete a post-intervention (3-months) quantitative assessment. Following the completion of the quantitative assessments, youth will receive the Entrepreneurship Training.
Bacterial O-antigen based active immunization comprises parenteral administration of extracted and purified O-antigen saccharide from potential pathogenic enterobacteria, which is cultured under iron limitation stress, such as Escherichia colipathotypes and Salmonellaserovar in a suspension for the induction of O-antigen-specific antibody, which is for the induction of the signal transduction as given in the specification, by the bacterial O-antigen-saccharide. This signal transduction is tangent over intrabacterial interaction determined gene product and gene. Bacterial O-antigen based active immunization comprises parenteral administration of extracted and purified O-antigen saccharide from potential pathogenic enterobacteria, which is cultured under iron limitation stress, such as Escherichia colipathotypes and Salmonellaserovar in a suspension for the induction of O-antigen-specific antibody, which is for the induction of the signal transduction as given in the specification, by the bacterial O-antigen-saccharide. This signal transduction is tangent over intrabacterial interaction determined gene product and gene, the specificity of fimbriae and/or fimbrial adhesin, flagellin, siderophore receptor, and the secretion of toxins, invasins and siderophores, where the regulation of the virulence is originated in the direction of the reduction. ACTIVITY : Antibacterial; Immunostimulant. MECHANISM OF ACTION : Vaccine.
CAPEOX program. Oxaliplatin: Day 1, 130mg/m2, IV infusion. Capecitabine: Day 1-14, 1000mg/m2 Twice Daily, po. A total of 6 cycles, 3 weeks apart of chemotherapy.
Panton-Valentine Leukokidin and other toxins play an important role in the severity of skin and soft-tissue infections due to Staphylococcus aureus. The inhibition of the protein synthesis could be beneficial, due to the major role of protein-toxins in the pathogenesis of skin and soft tissue infections. Clindamycin has a strong toxin-suppressive activity. Therefore, clindamycin is currently considered as the most-promising adjuvant antimicrobial agent in the treatment of toxin-mediated S. aureus infections. Recurrent infections are common in patients with S. aureus skin and soft-tissue infections. Clindamycin has been reported to reduce S. aureus colonisation, which may in turn reduce the risk for recurrent infections. Clindamycin is an already approved antimicrobial used for a wide range of indications and with a known safety profile.

This study is an investigator-led, investigator-initiated, open-label superiority randomised controlled trial that will be conducted at Masanga Hospital in Sierra Leone. The objectives of this study are to determine the feasibility, efficacy and safety of adjunctive clindamycin therapy (in addition to standard-of-care) compared to standard-of-care alone on clinical treatment outcomes in patients with skin and soft tissue infections due to S. aureus in Sierra Leone. This is a preliminary study, which will include 100 adult participants with skin and soft-tissue infections requiring systemic therapy.
Patients in arm vinorelbine and carboplatin follow the regimen: The scheduled infusion time is 6-10 minutes for IV vinorelbine at the dose of 25 mg/m2 d1,8, then carboplatin target area under the concentration curve (AUC) 6 (i.v. infusion over 30 minutes) on day 1 of a 21-day cycle. A total of four cycles is intended.
PURPOSE:To provide the preventive and remedy for mycoplasmosis of animal, having higher activity than tylosin, and containing a specific 1,4-benzoxazine-6- carboxylic acid derivative or its salt as an active component. CONSTITUTION:The titled preventive and remedy can be prepared by using the compound of fomula (X is halogen: R1 and R2 are alkyl) or its salt as an active component. Concrete example of the compound of formula is 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3 -de]-1,4-benzoxazine-6-carboxylic acid. The compound of formula has remarkable effect to the mycoplasmosis (e.g. mycoplastic pneumonia of cattle, epizootic pneumonia swine, chronic respiratory disease of chicken, etc.) and mixed infection diseases with mycoplasma and other bacteria. The compound is added to feed in an amount of 100- 200mg/kg.
BACKGROUND: Accompanied by the growing prevalence of nonalcoholic fatty liver disease (NAFLD), the coexistence of chronic hepatitis B (CHB) and NAFLD has increased. In the context of CHB, there is limited understanding of the factors that influence the development of NASH.
METHODS: We enrolled CHB combined NAFLD patients who had liver biopsy and divided them to NASH vs. non-NASH groups. A whole transcriptome chip was used to examine the expression profiles of long noncoding RNAs (lncRNAs) and mRNA in biopsied liver tissues. The function analysis of HIGD1A were performed. We knocked down or overexpressed HIGD1A in HepG2.2.15 cells by transient transfection of siRNA-HIGD1A or pcDNA-HIGD1A. In vivo investigations were conducted using hepatitis B virus (HBV) transgenic mice.
RESULTS: In 65 patients with CHB and NAFLD, 28 were patients with NASH, and 37 were those without NASH. After screening 582 differentially expressed mRNAs, GO analysis revealed differentially expressed mRNAs acting on nicotinamide adenine dinucleotide phosphate (NADPH), which influenced redox enzyme activity. KEGG analysis also shown that they were involved in the NAFLD signaling pathway. The function analysis revealed that HIGD1A was associated with the mitochondrion. Then, both in vivo and in vitro CHB model, HIGD1A was significantly higher in the NASH group than in the non-NASH group. HIGD1A knockdown impaired mitochondrial transmembrane potential and induced cell apoptosis in HepG2.2.15 cells added oleic acid and palmitate. On the contrary, hepatic HIGD1A overexpression ameliorated free fatty acids-induced apoptosis and oxidative stress. Furthermore, HIGD1A reduced reactive oxygen species (ROS) level by increasing glutathione (GSH) expression, but Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/Acetyl-CoA carboxylase (ACC) pathway was not involved.
CONCLUSION: Both in vivo and in vitro CHB model, an upward trend of HIGD1A was observed in the NASH-related inflammatory response. HIGDIA played a protective role in cells against oxidative stress. Our data suggested that HIGD1A may be a positive regulator of NASH within the CHB context.
Modern people use a smartphone along the day, including occupational and leisure activities. Repeated and prolonged use of smartphones affecting muscular activity and strength around the shoulders and upper back especially serratus anterior during maintaining an un ideal posture which may result in the development of postural changes as excessive thoracic kyphosis which in turn will result in inadequate muscles contractions, weakening of postural muscles and fatigue. Scapular muscles strength should be balanced or integrated (muscle balance) and worked in synchronized motion, so, alteration in scapulothoracic motion in resting position or dynamic motion of scapula described as scapulothoracic dysfunction. Muscle imbalances occurs and lower trapezius, serratus anterior and rhomboids muscles are the most common muscles prone to weakness due to exposure to sustained awkward posture or adaptive postures and restriction to specific activity. Continuous use of smartphone for more than 4 hours daily increases shoulder and parascapular pain, fatigue, decrease strength of scapular muscles (lower fibers of trapezius for scapular adduction and depression and rhomboids for scapular adduction and downward rotation) in right dominant side due to prolonged hyperactivity, then weakness.The excessive use of smartphones correlates with increases incidence of vertebral static disorders, especially kyphosis.

Scapular stabilization exercises were effective in the early rehabilitation and the balance of both sides of the trapezius with the movement and couple motion of the scapula. It is also effective in increasing muscle activation in the serratus anterior and lower trapezius.
An implantable medical device delivers neurostimulation therapy to a patient according to a parameter set. A parameter set may consist of a number of programs that are delivered substantially simultaneously. When programming the implantable medical device for the patient, a clinician programmer may maintain a session log for the patient that includes a listing of programs delivered to the patient and rating information provided by a clinician and the patient for programs of the list. The listing may be ordered according to the rating information in order to facilitate the selection of programs for a parameter set. A program library that may include particularly effective programs organized according to a directory structure may be stored in a memory. One or both of the implantable medical device and a patient programmer may store usage information that provides an objective assessment of therapy use by the patient, and allows a clinician to later improve the therapy based on the usage information.
The aim of the present study was to evaluate depressive-like, anxiety-like, and perseverative-like behaviors in a binge eating model. Juvenile Wistar rats, using the binge eating model, were compared to caloric restriction, induced stress, and control groups. Rats of the induced stress group presented binge-like behaviors in standard food intake in the second cycle of the experiment when compared to the caloric restriction group and the binge eating model group. Depressive-like behavior was observed in the binge eating model group with longer immobility time (p < 0.001) and less swim time (p < 0.001) in comparison to the control group. Anxiety-like behavior was observed by shorter duration of burying latency in the binge eating model group when compared to the induced stress group (p = 0.04) and a longer duration of burying time when compared to the control group (p = 0.02). We observed perseverative-like behavior by the binge model group, who made more entries to the new arm (p = 0.0004) and spent a longer time in the new arm when compared to the control group (p = 0.0001). Our results show differences in behaviors between the groups of rats studied. These results suggest that calorie restriction-refeeding, along with stress, may lead to depressive-like, anxiety-like, and perseverative-like behavioral changes in male Wistar rats.
AZD4635 capsule formulation 50 mg QD or 75 mg QD plus docetaxel. The pharmacokinetics of the single dose AZD4635 capsule formulation will be characterized on Cycle 1 Day 1 in Arm CC. Steady-state pharmacokinetics will be assessed on Cycle 1 Day 15. Cycles will be administered in 3-week cycles to assess the safety and dose-limiting toxicity (DLT). After Cycle 1, PKs will be collected on Day 1 of every even numbered cycle (Cycles 2, 4, and 6).
We analyzed the medical condition of 360 women affected by lipedema of the lower limbs in stages 1, 2, and 3. The data were assessed for the whole population and compared between different clinical stages, distinguishing between obese and non-obese patients. The most frequent clinical signs were pain when pinching the skin, subcutaneous nodules, and patellar fat pads. The most frequently painful site of the lower limbs was the medial lower third of the thigh. The pain score obtained on lower limb points increased progressively with the clinical stage. In all points evaluated, the thickness of the subcutaneous tissue increased with the clinical stage. Analyzing the data on the lower medial third of the leg and considering only patients with type 3 lipedema, the difference between stages was statistically significant after correction for age and BMI. We found higher levels of C-reactive protein at more severe clinical stages, and the difference was significant after correction for age and BMI between the stages. Overall, the prevalence of alterations of glucose metabolism was 34%, with a progressive increase in prevalence with the clinical stage. The most frequent comorbidities were vitamin D insufficiency, chronic venous disease, allergies, dyslipidemia, headache, and depression of mood. Interestingly, in comparison with the general population, we found higher prevalence of chronic autoimmune thyroiditis and polycystic ovary syndrome. Finally, the clinical stage and the involvement of the upper limbs or obesity suggest a worse clinical, anthropometric, and endocrine-metabolic profile.