anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Bupropion is a popular antidepressant due to its favorable side effect profile and indications for smoking cessation and weight loss. Due to the possibility of delayed onset seizure and other adverse outcomes after bupropion overdose, patients are often observed for periods of 12-24 hours following suspected ingestion. Tachycardia is a clinical predictor that holds promise in differentiating cases at risk for seizures from low-risk cases that do not require prolonged observation. This study assessed whether heart rate within the first eight hours of presentation can identify cases that do not require extended observation.
METHODS: This is a retrospective cohort study of all supra-therapeutic bupropion cases from two hospital systems between 2010 and 2022.
RESULTS: Data from 216 charts were included. Seizures, hypotension, and dysrhythmias occurred in 19 percent (n = 41), 1.4 percent (n = 3), 0.9 percent (n = 2) respectively. One patient died. Delayed adverse effects were rare (n = 4); they occurred from 14 hours to 28 hours post-ingestion. Maximum heart rate in eight hours was associated with a risk of adverse outcomes. (odds ratio, 1.07; 95 percent confidence interval: 1.05 to 1.09; P < 0.001). An eight hour maximum heart rate threshold of 104 beats/minute had a negative predictive value of 100 percent (95 percent confidence interval: 96.7 percent to 100 percent) for the occurrence of delayed adverse effects. All patients with delayed effects had tachycardia within five hours of emergency department arrival.
DISCUSSION: Delayed adverse outcomes of seizures, hypotension, dysrhythmia, and death were uncommon in this cohort. Heart rate during the first eight hours of observation performs reliably as a screening test to identify patients at low risk for delayed adverse outcomes. This study is limited by its retrospective nature, the inability to ascertain time of ingestion for most cases and the lack of confirmatory laboratory testing.
CONCLUSION: This study supports the use of an eight hour observation period when there are no other clinical signs of toxicity to warrant admission and if no co-ingestion or administration of substances that mask tachycardia are present.
The ill effects of isosorbide mononitrate overdose are generally the result of isosorbide mononitrate's capacity to induce vasodilatation, venous pooling, reduced cardiac output, and hypotension. These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; vertigo, palpitations; visual disturbances; nausea and vomiting (possibly with colic and even bloody diarrhea); syncope (especially in the upright posture); air hunger and dyspnea, later followed by reduced ventilatory effort; diaphoresis, with the skin either flushed or cold and clammy; heart block and bradycardia; paralysis; coma; seizures and death.

Laboratory determinations of serum levels of isosorbide mononitrate and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of isosorbide mononitrate overdose.

There are no data suggesting what dose of isosorbide mononitrate is likely to be life threatening in humans. In rats and mice, there is significant lethality at doses of 2000 mg/kg and 3000 mg/kg, respectively.

No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) that might accelerate elimination of isosorbide mononitrate. In particular, dialysis is known to be ineffective in removing isosorbide mononitrate from the body.

No specific antagonist to the vasodilator effects of isosorbide mononitrate is known, and no intervention has been subject to controlled study as a therapy of isosorbide mononitrate overdose. Because the hypotension associated with isosorbide mononitrate overdose is the result of venodilatation and arterial hypovolemia, prudent therapy in this situation should be directed toward an increase in central fluid volume. Passive elevation of the patient's legs may be sufficient, but intravenous infusion of normal saline or similar fluid may also be necessary.

The use of epinephrine or other arterial vasoconstrictors in this setting is likely to do more harm than good.

In patients with renal disease or congestive heart failure, therapy resulting in central volume expansion is not without hazard. Treatment of isosorbide mononitrate overdose in these patients may be subtle and difficult, and invasive monitoring may be required.
Continuous exercise of maximal exertion that has been work matched to an initial bout of interval exercise of 4 x 30s of maximal exercise. This exercise is performed on a cycle ergometer.
Techniques of the Cognitive Behavior Therapy combined with drug dependence psychoeducation was developed by research team. BDRC consists of 12 sessions, including an initial session, 3 drug education sesssions, psychosocial counseling and behavioral skills. This initial session is designed to introduce the counselor, review the purpose and expectations of counseling, review the rules of confidentiality, agree on attendance times and rescheduling rules, and to begin to collect information from the participant on their drug use and risk behaviors. Behavioral contracting is a key component to this counseling approach. Drug education focuses on how heroin may influence patients' cognitive function and their HIV/HCV risk behaviors. Counseling and behavior skills trained patients to reflect their thoughts and learned new life skills in order to delay or abstrain from heroin use.
The invention belongs to the technical field of film coating and discloses a damp-proof film coating agent. The damp-proof film coating agent comprises components in parts by mass as follows: a film forming agent and a solvent in a ratio being 1:(2-10), wherein the film forming agent is selected from one or more of stearic acid, beewax, collodion, ethyl cellulose and prolamine; the solvent is selected from one or more of ethanol, acetone, propane, ethyl ether and dimethyl ether. The preparation method of the damp-proof film coating agent comprises steps as follows: the raw materials in the formula ratio are taken, mixed and stirred until the film forming agent is dissolved completely, and the mixture is uniformly stirred. The invention further discloses a salt film coating method. The salt film coating method comprises steps as follows: the film coating agent and the solvent in the formula ratio in Claim1 are taken, mixed and stirred until the film forming agent is completely dissolved, the mixture is uniformly stirred, and a film coating solution is obtained; (2), salt and the prepared film coating solution are uniformly stirred, mixed and air-dried. The damp-proof film coating agent and the salt film coating method have good application prospect in the aspect of film coating damp-proof processing of low sodium salt and granules containing magnesium sulfate, potassium chloride, sodium chloride, calcium chloride and the like.
System and method for lidar-based anatomical mapping is provided. In one implementation, a LIDAR imaging technology is utilized to create a surface-based anatomical map of an exposed anatomical surface of at least a portion of the spine, or other anatomical features, using anatomical and/or artificial landmarks are disclosed. The surface mapping can then be registered with previously acquired images of at least the portion of the spine, or other anatomical features. The surface mapping can then be used to identify important structures, including an entry point in tissue (including soft tissue and bone) for the placement of a medical instrument or implant, or for the orientation of a medical instrument or device. The information can be displayed in an augmented reality overlay on a device display (e.g., wearable eyeglasses). The LIDAR imaging technology may be incorporated into wearable eyeglasses.
Cannabidiol (CBD) is disclosed for use as an adjunct medicament in the treatment of mental disorders where psychotic symptoms are being treated with a typical or an atypical antipsychotic, wherein the CBD is for use to augment the effect of the antipsychotic medicament. The antipsychotic may be olanzapine or quetiapine. Also disclosed are compositions comprising CBD in combination with one or more antipsychotics such as olanzapine and quetiapine. In particular the adjunct therapy relates to the treatment of schizophrenia or related psychotic disorders, more particularly those which are considered to be treatment resistant. The adjunct therapy may also be used to treat positive and/or negative symptoms in mental orders such as schizophrenia, i.e., anhedonia, asociality, avolition, apathy, attention disturbance or cognitive symptoms such as working memory, motor speed and executive function. CBD may also be used as a monotherapy to treat said positive/negative symptoms.
The invention provides a soaking agent for treating dermatophytosis and rhagadia manus and pedalis. The soaking agent is characterized in that: on the basis of a hereditary secret formula, 10 kinds of pure Chinese herbal medicines including radix ampelopsis and the like are used for developing a flaxen liquid decoction. The soaking agent is slightly fragrant in smell, bitter and sweet in taste and cool in nature, and is a specific medicine for specially treating rhagadia manus and pedalis, dermatophytosis and the like. The soaking agent has the functions of promoting blood circulation and cooling blood, removing blood stasis and dispersing phlegm, removing slough and promoting tissue regeneration, dispersing pathogenic wind and removing humidity, clearing away heat and toxic material, moisturizing the skin and relieving itching, resisting fungi and the like. Compared with the similar medicines, the soaking agent has excellent effects, wherein rhagadia manus and pedalis can be cured by soaking for 1-3 courses of treatment (one course of treatment lasts for 10 days), and dermatophytosis and other diseases can be cured by soaking for 4-7 days. The affected part needs to be soaked in the liquid medicine for about 1 hour once per day, the treatment effect reaches more than 98%, the diseases can be radically cured, and the blood pressure can be reduced by soaking for a long time. The soaking agent also has a treatment effect on ungual tinea, dermatitis, skin pain and skin ulcer, is convenient to use, and has no toxic side effects, sequelae or irritation. The soaking agent has wide medicine sources, is simple and easy to prepare, is of high social demand and is economical and practical, thereby being a good medicine beneficial to patients. The soaking agent does not have corrosion resistance, thus a proper amount of edible preservative can be added when the soaking agent is prepared. The dregs of a decoction are organic fertilizers for crops.
New compds, of formula (I) (where R1 is a tetraazole ring linked through an N-atom and R2 is H, OH, esterified OH or their S-analogues, opt. N-substd. carbamoyloxy or their S-analogues or quaternary amino) and their salts are antibiotics and animal feedstock additives. They are prepd. by standard acrylation methods. Medicaments are in forms suitable for enteral, parenteral and topical administration.
FIELD: medicine. SUBSTANCE: method involves intramuscularly administering autoblood once a day at a dose of 5 cm 3  saturated with 15 cm 3  of ozone and oxygen mixture with ozone concentration of 30 mcg/ml in addition to aminoquinoline preparations or presocyl with nicotinic acid in the same syringe twice a week. The course is to 10 injections long. An additional intramuscular injections course is carried out once a day with 10 cm 3  of ozone and oxygen mixture having ozone concentration of 30 mcg/ml. The injections are done three times a week with total amount of up to 10 injections. EFFECT: enhanced effectiveness of treatment; avoided adverse side effects; low cost. 1 tbl
The invention discloses a production method of a lotus tea wine which is prepared from the raw materials of, by weight: 5-14 parts of sweet tea, 10-20 parts of lotus, 80-100 parts of glutinous rice, 10-15 parts of sweet potato, 10-15 parts of pea, 1-2 parts of common anemarrhena, 1-2 parts of raw rehmannia rhizome, 2-3 parts of creeping liriope, 1-2 parts of dwarf cowlily rhizome, 2-4 parts of blueberry leaf, 2-3 parts of medlar, 1-2 parts of Chinese gentian, 1-2 parts of chinese mosla herb, 2-3 parts of perilla leaf, 1-2 parts of Sanchi flower, 2-3 parts of Chinese mesona herb, 20-32 part of distillate spirit, 5-9 parts of rock sugar, 2-4 parts of distiller's yeast, and proper amount of water. The tea wine has refreshing fragrance and good taste. Lotus and sweet tea are adopted in the formula, such that body fluid regenerating, thirst quenching, heart clearing, and blood circulation promoting functions are provided. Also, traditional Chinese medicine components such as Sanchi flower and creeping liriope are added, such that anticancer, anti-aging, and immunity-enhancing functions are added. With the method, health-care value is enhanced. The wine is a nutritional health-care wine with low alcohol degree, and is beneficial for human health.
PCT No. PCT/JP79/00141 Sec. 371 Date Feb. 2, 1980 Sec. 102(e) Date Jan. 31, 1980 PCT Filed Jun. 1, 1979 PCT Pub. No. WO80/00024 PCT Pub. Date Jan. 10, 1980.The present invention relates to a novel compound represented by the general formula:  <IMAGE>  wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents  <IMAGE> wherein R1 represents a hydrogen atom, or an alkyl, alkanoyl or alkoxycarbonyl group, R represents a hydrogen atom or an alkyl group, and Z represents a substituted benzimidazolinyl group; the broken line in piperidine ring means that 3,4-positions in the piperidine ring are saturated or form a double bond. Said compound and the pharmaceutically acceptable acid addition salts thereof have a hypotensive action and therefore are useful as medicine.
Opti-Free® PureMoist® MPDS used first, followed by RevitaLens MPDS. Each product used as indicated for 30 days with participant's habitual contact lenses.
Whether maternal exposure to dust-sourced particulate matter (hereafter, dust PM2.5) is associated with stillbirth remains unknown. We adopted a sibling-matched case-control design to analyze 9332 stillbirths and 17,421 live births. We associated the risk of stillbirth simultaneously with dust and nondust components of PM2.5 and developed a nonlinear joint exposure-response function. Next, we estimated the burden of stillbirths attributable to the PM2.5 mixture. The concentration index was used to evaluate whether the burden of PM2.5-related stillbirths was disproportionally distributed among pregnancies exposed to dust-rich particles. Each 10 μg/m3 increase in dust PM2.5 was associated with a 14.5% (95% confidence interval: 5.5, 24.2%) increase in the odds of stillbirth. Based on the risk assessment across 137 countries, sand dust contributed to about 15% of the PM2.5 exposure but to about 45% of the PM2.5-related stillbirths during 2003-2019. In 2015, 30% of the PM2.5-related stillbirths were concentrated within 15% of pregnancies exposed to the dust-richest PM2.5. The index increased in subregions, such as South Asia, suggesting the growth of health inequality due to exposure to dust PM2.5. Based on our findings, land management, such as halting desertification, will help prevent stillbirths and reduce global maternal health inequality.
A rapid point of care bioassay for the detection of virus proteins will be compared to the hospital validated RT-PCR detection standard. Nasopharyngeal, nasal and saliva samples will be collected along with hospital standard of care collection. Nasal and saliva will be self-administered collection. Samples will be collected in an Emergency Room setting from up to 100 subjects who entered the hospital over concerns about SARS-CoV-2. The goal is to collect a minimum of N=30 confirmed Covid-19 positive subjects and N=30 confirmed Covid-19 negative subjects of comparable ages, genders and races. The SARS-CoV-2 Direct Antigen Rapid Test ("DART") is an immunoassay for point-of-care, qualitative detection of SARS-CoV-2 viral particles/secreted protein in nasopharyngeal swabs from suspected patients with Coronavirus Disease 2019 or COVID-19 infection. Dipsticks are printed with a monoclonal antibody that binds the signature SARS-CoV-2 viral particles/protein (Test line) and a control antibody (Control line) for quality control. A second monoclonal antibody is attached to gold nanoparticles (conjugate) and quencher buffer, and mixed with the patient samples, though in the near future the final format will contain the dry conjugate. The SARS-CoV-2 viral particles/Spike protein attach to both antibodies resulting in a visual line on the test strip within 15 minutes. Prior experience for detection virus and viral proteins via antibody binding using lateral flow are E25Bio portfolio platform for dengue, Zika and Chikungunya viruses among others.
Approximately half of the subjects randomized into HALF-PINT will be randomized into TGC-2 which will seek to maintain the subject's blood sugar between 150-180 mg/dL. Intravenous insulin may be administered per insulin algorithm.
Foot pain is common in the general population, with prevalence estimates ranging from 17 to 30% . A systematic review concluded that nearly one-quarter of adults over age 45 experience frequent foot pain. Foot pain has been associated with poor balance, gait problems, the limitation of daily living activities, and health-related quality of life. It has been reported that at least two-thirds of individuals experience moderate functional daily life problems .The etiology of hindfoot pain is mostly associated with Achilles Tendinopathy and Plantar Fasciitis, which are prevalent, affecting millions of people each year . Most cases of hindfoot pain if not treated, they will get worse with time and resistant symptoms. This is why to get more information on prevalence and risk factors in the general population is necessary to organize health care planning and the extent of clinical need.An increase in the use of digital technology and smart phones globally with mobile applications provide an alternative solution to the planning of primary health care services. In the US, approximately 90% of adults have a mobile phone, and 58% of these prefer smart phones, while in Turkey, 98% of adults use mobile phones, and 77% of them are smart phones owners. The popularity of smart phones provides opportunities for reaching information and giving skills to users through applications. These applications offer new opportunities for collecting, evaluating, and monitoring health information and have portability, the flexibility of use, and a width of the access area.With the concept of this approaching (using digital technologies,) several systematic reviews have examined digital programs using for different health conditions/ pathologies (paralysis, lack of balance/stabilization, cardiac disorders, and joint / extremity). A great deal of physiotherapy interventions for hindfoot pain includes electrotherapy agents, 'hands-on' therapy, stretching, and strengthening exercises. The exercise programs are an essential part of rehabilitation programs for hindfoot pain, and patients who involved in this exercise program also need to get feedback by physiotherapist. For this reason, the digital technology-based applications are considered to be contributive for follow-up exercise regularly and detecting the changes and progression. Additionally, to the best of our knowledge, a smartphone application research involving hindfoot pathology with suggesting assessment methods and including exercise program is not available in the literature. Thereby, the study aims to evaluate the status of the individuals with hindfoot pain and to recommend preventive precautions and appropriate exercise programs with Smart Phone-Based Applications and to compare the results of patients who attended through mobile applications (Achilles Tendinopathy and Plantar Fasciitis) with the results of patients included in the hands-on program.
In the formation and growth of a primary tumor, cells can released into the bloodstream. There are many researches for these circulating tumor cells(CTC) And recently circulating cell-free tumor DNA(ctDNA) released from apoptotic or necrotic tumor cells has developed. At one report which checked ctDNA level after operation of colon cancer patients, they suggested that ctDNA could show recurrence of cancer several months earlier than the conventional follow up imaging. And several reports suggested that ctDNA can invade host cell and change host cell biology, which can evoke cancer metastasis.

So in this study, the investigator will collect ctDNA of pancreatic cancer patients, benign pancreatic disease patients, and healthy population. And the investigator will evaluate whether peripheral ctDNA can help early screening of cancer recurrence. And we will study about genomic signature of ctDNA to evaluate relationship between ctDNA and clinical outcome of cancer patients.
Ischemia reperfusion injury (IRI) induced renal failure after kidney transplantation is a common clinical problem associated with a high morbidity and mortality. To reduce the adverse effects of IRI after organ transplantation various strategies aimed at the different pathophysiological processes of IRI have been investigated. Remote ischemic preconditioning (RIPC) is one such strategy where brief IRI of one organ protects other organs from sustained IRI. Many studies have shown that RIPC protects heart, muscle flaps, stomach, liver, lungs, and kidneys from IRI. RIPC of the limb with a tourniquet is a safe and convenient method of preconditioning organs against IRI. However, the efficacy of RIPC in patients undergoing living donor kidney transplantation need to be established and mechanism of early and late RIPC, such as whether the donor should undergo remote preconditioning or the recipient, need to be investigated.
BACKGROUND: Concurrent spinal pathology is frequent in patients undergoing total hip arthroplasty (THA). In this study we examined whether spinopelvic interactions affect THA outcomes at a minimum follow-up of 10 years.
PATIENTS AND METHODS: 295 patients with a mean age of 63.3 (range 56‒80) years receiving a THA between 2006 and 2009 were assessed. Of these, 195 had mild lumbar disc degeneration and 100 had advanced lumbar spondylosis. We analysed the changes in the Harris Hip Score (HHS) and the survival rate for postoperative low back pain (LBP) and dislocation. Changes in acetabular component position, sacro-femoral-pubic (SFP) and pelvic obliquity (PO) angles were assessed with radiological images.
RESULTS: The mean HHS was lower in female patients (p = 0.009), patients >65 years of age (p < 0.001) and those with advanced lumbar spondylosis (p = 0.002). 52 (71.2%) of the patients reporting preoperative LBP experienced improvement after THA while 47 (21.1%) of those without preoperative LBP postoperatively reported new onset LBP. Female patients (p = 0.025; hazard ratio [HR]: 1.831; 95% CI, 1.081-3.101) and those with preoperative LBP (p = 0.007; HR 2.068; 95% CI, 1.221-3.504) were at a higher risk of developing postoperative LBP at 10 years. 4 out of 9 THA dislocations were late and had shown decreasing SFP angle values over time. Acetabular component inclination and anteversion angles increased over time, whereas the SFP angle was associated with sex and age and the PO angle with age and the severity of any preoperative lumbar degeneration.
CONCLUSIONS: Concurrent spinal pathology influences THA outcomes at a minimum follow-up of 10 years. Sex, age, and associated lumbar degeneration can affect clinical and radiological changes over time. A decrease in SFP angle values over time was found in patients sustaining late dislocation.