anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Treatment with somatropin may decrease insulin sensitivity, particularly at higher doses in susceptible patients. As a result, previously undiagnosed impaired glucose tolerance (IGT) and overt diabetes mellitus may be unmasked during somatropin treatment, and new onset type 2 diabetes mellitus has been reported in patients taking somatropin. Therefore, glucose levels should be monitored periodically in all patients treated with somatropin, especially in those with risk factors for diabetes, such as obesity, Turner syndrome (TS), or a family history of diabetes mellitus. Patients with preexisting type 1 or type 2 diabetes mellitus or IGT should be monitored closely during somatropin therapy. The doses of antihyperglycemic drugs (i.e. insulin or oral/injectable agents) may require adjustment when somatropin therapy is instituted in these patients.
Participants will engage in the Responsible, Engaged and Loving (REAL) Fathers Intervention-an evidence-based community mentoring education program for young fathers and their spouses. Over 7 months, fathers receive monthly home visits from a community-identified male mentor. Mentors share information and skills-building tools on conflict resolution, non-violent discipline, family planning, and couple communication. At the end of each month, pairs or trios of mentors hold group reflection sessions with all mentored fathers. In months 5 and 6 of the intervention, spouses join the home visits and group sessions. Community-level intervention components include: 1) monthly educational poster campaigns that showcase nonviolent discipline and conflict resolution strategies; 2) community-hosted celebrations at the end of the intervention to acknowledge the accomplishments of the young fathers.
Surgery remains the mainstay in patients with symptomatic pile grades III and IV. The usual operation by Milligan-Morgan and Ferguson is still most used and effective for symptomatic grades IV and some of grade III. The two procedures get mimicked, like blood loss and postoperative pain, which cause prolonged hospital stay. Rapid wound healing permits the early return to usual works and day activity . Many articles seek the best treatments of piles published in recent years and modern device the procedures trials to overcome the haemorrhoidectomy complication.: like stapling, laser, doppler-guided vessels ligation with different principles aimed at excisional surgery. The LigaSure system vessels sealed were introduced newly in \[6\] as a tool for treatments of piles. It is a bipolar electro-thermal device; it offers both radiofrequency and pressure. Blood vessels seal up to 7mm in diameter and create energy according to the tissue impendence and confined 2 mm thermal injury over operation site. The limited thermal injury spread decreases the anal spasm and permits bloodless surgery to decrease postoperative pain and promote rapid healing. So the operation is recommended as an ideal procedure because of the significant less tissue trauma . The objective of some randomized trials to estimate the advantage of the LigaSure approach over the conventional diathermy approaches. in spite of the favourite toward the LigaSure, the conclusion gets some uncertainly regarding the cost of using disposable device although an overall favourable trend exists toward LigaSure, conclusions are not univocal and definitive; this creates some uncertainty, also considering the increasing cost for the use of the disposable device so essential to compare our study with another centres to emphasis the true advantage present. The debate is the "gold standard" for III degrees. There are large agreements that Milligan-Morgan and Ferguson are the most effective in IV degree pile . Ortiz mentions that stapled procedure is ineffective for curing itching in an IV degree pile . So the diathermy pile excision continues as an effective therapy for the symptomatic, irreducible and prolapsed pile. The designed study to estimate the LigaSure procedures as effective as conventional diathermy in all grades IV and III with less pain, less blood loss and when we need large tissue excision needed.
PROBLEM TO BE SOLVED: To obtain a skin care preparation having a high effect for preventing and recovering damage of the skin by ultraviolet rays and an excellent sense of use free from stickiness. SOLUTION: This skin care preparation comprises alanine, an ultraviolet light absorber and an ultraviolet scattering agent. The ultraviolet light absorber is one or more kinds of ultraviolet light absorbers selected from the group consisting of a cinnamic acid derivative, a dibenzoylmethane derivative, a benzophenone derivative and a shea butter. The ultraviolet scattering agent is one or more kinds of ultraviolet scattering agents selected from the group consisting of titanium oxide, zinc oxide and substances obtained by hydrophobilizing these compounds. The content of alanine is 0.01-10.0 mass % based on the total amount of the skin care preparation. The content of the ultraviolet light absorber and the ultraviolet scattering agent is 1.0-50.0 mass %.
Background: Resection of additional tissue circumferentially around the cavity left by lumpectomy (cavity shave) was suggested to reduce rates of positive margins and re-excision. Methods: A single center retrospective study which analyzed margins status, re-excision, and surgical time in patients who underwent breast conserving surgery and cavity shave or intraoperative evaluation of resection margins. Results: Between 2021 and 2023, 594 patients were enrolled in the study. In patients subjected to cavity shave, a significant reduction in positive, focally positive, or closer margins was reported 8.9% vs. 18.5% (p = 0.003). No difference was reported in terms of surgical re-excision (p < 0.846) (5% vs. 5.5%). Surgical time was lower in patients subjected to cavity shave (<0.001). The multivariate analysis intraoperative evaluation of sentinel lymph node OR 1.816 and cavity shave OR 2.909 were predictive factors for a shorter surgical time. Excluding patients subjected to intraoperative evaluation of sentinel lymph node and patients with ductal carcinoma in situ, patients that underwent the cavity shave presented a reduced surgical time (67.9 + 3.8 min vs. 81.6 + 2.8 min) (p = 0.006). Conclusions: Cavity shaving after lumpectomy reduced the rate of positive margins and it was associated with a significant reduction in surgical time compared to intraoperative evaluation of resection margins.
Participants will be exposed to the 9-week MBSR program, facilitated by a trained MBSR facilitator. Due to COVID-19, the program will be held virtually.
Pembrolizumab will be administered every 3 weeks in combination with ramucirumab + paclitaxel. The paclitaxel schedule differs between the 2 arms.
PROBLEM TO BE SOLVED: To provide a method for using a composition for external use so that human skin barrier function is always kept constant and well-balanced healthy skin is easily maintained by applying the composition for external use containing a specific ingredient to the skin at a specific point of time. SOLUTION: This method for using a composition for external use comprises applying to the skin, at a point of time when the recovery power of human skin barrier function is lowered, pref. at any point of time from 19 to 23, the composition for external use containing an ingredient capable of improving the recovery power of the above-mentioned human skin barrier function (pref. one or more kinds selected from amino acids such as L-arginine, saccharides such as xylitol, polyols such as glycerol, and the like), pref. at the rate of 0.01-10.0 wt.% based on the whole weight of the composition to maintain the human skin barrier function. The above-mentioned composition is provided in the form of a skin lotion, milky lotion, cream or the like.
Families in settings assigned to intervention will receive Adult Day Services (ADS) as usual in addition to ADS Plus. ADS Plus has 5 key components: care management, referral/linkage; disease education; counseling/emotional support/stress reduction, and care skills managing daily challenges and behavioral disturbances. The intervention begins with 2 face-to-face sessions with the site interventionist to conduct a needs assessment to identify concerns and needs and develop an agreed upon care plan. The interventionist then meets with caregivers face-to-face at convenient times to implement the care plan, every other week for the first 3 months, and then for monthly reassessments for newly emerging care concerns thereafter. Contact occurs about a minimum of 1 hour per month over 12 months.
The invention provides a patch for treating skin wounds. The patch for treating skin wounds mainly comprises a binder layer, a medicine storage layer and a protection layer. The binder layer is used for being pasted around a wound. The medicine storage layer is used for storing Chinese herbal medicines for healing the wound. The protection layer is used for protecting the stored medicines and preventing the wound from harm. The binder layer, the medicine storage layer and the protection layer comprise air breathable materials. The patch also comprises a water accepting layer and is characterized in that the Chinese herbal medicines comprise 5 to 20% of common rush, 10 to 15% of pomegranate rind, 5 to 15% of agrimony, 5 to 15% of phoenix tree leaf, 5 to 10% of common bletilla rubber, 10 to 15% of herb of denseleaf crazyweed and the balance auxiliary materials.
The invention provides a kind of recombinant expression vector of simultaneously expressing H5N1 subtype avian influenza synonym hemagglutinin and synonym neuraminidase protein, does is the aminoacid sequence of wherein said synonym hemagglutinin SEQ? ID? NO:1, does is the aminoacid sequence of described synonym neuraminidase protein SEQ? ID? NO:2, will be described recombinant expression vector by encoding SEQ? ID? the nucleotide sequence of NO:1 and coding SEQ? the nucleotide sequence of IDNO:2 is inserted in same expression vector to build and forms.The invention provides the DNA vaccination of the above-mentioned recombinant expression vector including effective amount, described vaccine effectively can prevent and/or treat the infection of H5 subtype avian influenza virus.The present invention relates to the application as the immunogen gene of H5 subtype influenza inactivated vaccine and other recombinant vaccines of described albumen or its coding nucleotide sequence simultaneously.
PURPOSE: A cosmetic material stabilizing composition containing a polyol compound with 4 or more hydroxyl groups is provided to ensure a moisturizing effect without dust and convenience in distribution, and to prevent a separation phenomenon. CONSTITUTION: A cosmetic material stabilizing composition contains a polyol compound with 4 hydroxy groups. A cosmetic composition contains a polyol compound with 4 hydroxy groups. The polyol compound is pentaerythritol and a derivative thereof. The composition contains 5-40% of the polyol compound. The cosmetic composition is manufactured in the form of a skin softener, an astringent, a nutrition lotion, nutrition cream, massage cream, eye cream, an eye essence, an essence, cleansing cream, a cleansing lotion, cleansing foam, cleansing water, a pack, powder, a body lotion, body cream, a body essence, a body cleanser, a hair dyeing agent, a shampoo, a rinse, toothpaste, an oral cleanser, a lotion, an ointment, a gel, cream, a patch, or a spray. [Reference numerals] (AA) 37°C stability; (BB) 25°C stability; (CC) 45°C stability; (DD) Cycle stability; (EE) 4°C stability
Bands are selected and an alginate impression taken over the bands. The impression will be sent to the lab for the construction of a transpalatal archwire on a 1.0 mm stainless steel wire connecting the upper permanent first molar, with a U loop pointing posteriorly, soldered to the palatal side of the molar bands. The appliance will be fitted a week later. Molar bands will be fitted to the permanent second molar on the same appointment, with a ligature wire tying the first molar band together at the buccal tubes. The resulting anchorage reinforcement is a molar block with a transpalatal archwire.
This case study illustrates a multidisciplinary diagnostic and therapeutic model of care for a 7-year-old male with Lamb-Shaffer syndrome (LAMSHF). LAMSHF is an ultra-rare genetic neurodevelopmental disorder, caused by heterozygous alterations in the SOX5 gene. An integrative model of therapy of cognitive functions and speech is described. The presented approach allows the development of language competences through stimulation of basic cognitive functions, which allows the learning of the abstract rules of an inflected language. A surprising, unexpected improvement in the cognitive functioning of the child was observed (both in terms of reasoning and speech), as well as an increase in his independence. The clinically important problem of the need for continued stimulation of cognitive development, in spite of the unfavourable prognosis associated with LAMSHF, is highlighted.
The problem: Knee Osteoarthritis (OA), the most common form of arthritis, is a chronic, widespread disease with a steadily increasing prevalence that places a major economic burden on the society. Patients with knee OA suffer from chronic knee pain and functional disabilities. The treatment that patients with knee OA are offered varies largely, and is often not in coherence with clinical guidelines. The guidelines recommend patient education, exercise, and weight control as core interventions for all patients with knee OA and surgical intervention for end-stage knee OA. However, the timing of surgery is debated, and whether the outcome of different treatment strategies depend on individual factors such as the patients symptoms, OA severity, or prior treatment, has not been established.

The solution: This large-scale study aims at improving the understanding of which treatment should be offered to which patient with knee OA at which time. The study is an interdisciplinary, collaborative effort, including orthopaedic surgeons, physiotherapists and general practitioners from two different regions in Denmark. At least 5,000 patients with primary referrals to orthopaedic surgeons due to knee OA, at two public hospitals, will be recruited through a two-year inclusion period. Patients' prior treatment and symptom severity will be registered at the first consultation with the orthopaedic surgeon using a patient self-reported questionnaire. OA severity will be defined on plain standing knee radiographs using a well-established classification system. The course of treatment will be registered after 6 months and 2 years through a self-reported questionnaire with additional questions asking whether patients can accept their current symptom state, or, if not, whether they consider the treatment to have failed.

Societal impact and clinical implications: The understanding of knee OA treatment will advance in three ways: Firstly, our results will improve the overview by describing the different treatment pathways that are currently being used for knee OA. Secondly, predictors of good and poor treatment outcomes of different treatment modalities, or combinations hereof will be identified. And finally, the cost-effectiveness of different treatment modalities will be evaluated. These results will be used to develop a treatment algorithm to help patients with knee OA and clinicians to tailor the right treatment at the right time through shared decision-making.
Patients receive 3-AP (Triapine®) IV over 4 hours followed by fludarabine phosphate IV over 30 minutes on days 1-5. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
During any infectious disease outbreak, effective and timely quarantine of infected individuals, along with preventive measures by the population, is vital for controlling the spread of infection in society. Therefore, this study attempts to provide a mathematically validated approach for managing the epidemic spread by incorporating the Monod-Haldane incidence rate, which accounts for psychological effects, and a saturated quarantine rate as Holling functional type III that considers the limitation in quarantining of infected individuals into the standard Susceptible-Exposed-Infected-Quarantine-Recovered (SEIQR) model. The rate of change of each subpopulation is considered as the Caputo form of fractional derivative where the order of derivative represents the memory effects in epidemic transmission dynamics and can enhance the accuracy of disease prediction by considering the experience of individuals with previously encountered. The mathematical study of the model reveals that the solutions are well-posed, ensuring nonnegativity and boundedness within an attractive region. Further, the study identifies two equilibria, namely, disease-free (DFE) and endemic (EE); and stability analysis of equilibria is performed for local as well as global behaviours for the same. The stability behaviours of equilibria mainly depend on the basic reproduction number R0 and its alternative threshold T0 which is computed using the Next-generation matrix method. It is investigated that DFE is locally and globally asymptotic stable when R0<1. Furthermore, we show the existence of EE and investigate that it is locally and globally asymptotic stable using the Routh-Hurwitz criterion and the Lyapunov stability theorem for fractional order systems with R0>1 under certain conditions. This study also addresses a fractional optimal control problem (FOCP) using Pontryagin's maximum principle aiming to minimize the spread of infection with minimal expenditure. This approach involves introducing a time-dependent control measure, u(t), representing the behavioural response of susceptible individuals. Finally, numerical simulations are presented to support the analytical findings using the Adams Bashforth Moulton scheme in MATLAB, providing a comprehensive understanding of the proposed SEIQR model.
Resistance to therapy is a major clinical obstacle to treatment of cancer and communicable diseases. Drug selection in treatment of patients where the disease is showing resistance to therapy is often guided by IC50 or fold-IC50 values. In this work, through a model of the treatment of chronic myeloid leukaemia (CML), we contest using fold-IC50 values as a guide for treatment selection. CML is a blood cancer that is treated with Abl1 inhibitors, and is often seen as a model for targeted therapy and drug resistance. Resistance to the first-line treatment occurs in approximately one in four patients. The most common cause of resistance is mutations in the Abl1 enzyme. Different mutant Abl1 enzymes show resistance to different Abl1 inhibitors and the mechanisms that lead to resistance for various mutation and inhibitor combinations are not fully known, making the selection of Abl1 inhibitors for treatment a difficult task. We developed a model based on information of catalysis, inhibition and pharmacokinetics, and applied it to study the effect of three Abl1 inhibitors on mutants of the Abl1 enzyme. From this model, we show that the relative decrease of product formation rate (defined in this work as "inhibitory reduction prowess") is a better indicator of resistance than an examination of the size of the product formation rate or fold-IC50 values for the mutant. We also examine current ideas and practices that guide treatment choice and suggest a new parameter for selecting treatments that could increase the efficacy and thus have a positive impact on patient outcomes.
At the induction of anesthesia, and every 15 minutes during operation following parameters were recorded: heart rate (HR), systolic blood pressure (BP), end-tidal CO2 (etCO2) and BIS level. Also, operation time and extubation time were recorded. Finally, all patients were visited on the first postoperative day and interviewed about intraoperative recall.
<P>PROBLEM TO BE SOLVED: To provide a method for diagnosing prostate cancer comprising the step of detection of the presence or absence of an expression product of the HML-2 endogenous retrovirus in the patient sample.  <P>SOLUTION: The human endogenous retrovirus of the HML-2 family shows up-regulated expression in prostate tumor. This finding can be used in prostate cancer screening, diagnosis and therapy. This method includes the step of detection of the presence or absence of expression products of the virus in the patient sample. The high level of the expression product relating to the normal tissue indicates that the examined patient has the cancer.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Infections of hepatotropic viruses cause a wide array of liver diseases including acute hepatitis, chronic hepatitis and the consequently developed cirrhosis and hepatocellular carcinoma (HCC). Among the five classical hepatotropic viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) usually infect human persistently and cause chronic hepatitis, leading to major troubles to humanity. Previous studies have revealed that several types of inflammasomes are involved in the infections of HBV and HCV. Here, we summarize the current knowledge about their roles in hepatitis B and C. NLRP3 inflammasome can be activated and regulated by HBV and HCV. It is found to exert antiviral function or mediates inflammatory response in viral infections depending on different experimental models. Besides NLRP3 inflammasome, IFI16 and AIM2 inflammasomes participate in the pathological process of hepatitis B, and NALP3 inflammasome may sense HCV infection in hepatocytes. The inflammasomes affect the pathological process of viral hepatitis through its downstream secretion of inflammatory cytokines interleukin-1β (IL-1β) and IL-18 or induction of pyroptosis resulting from cleaved gasdermin D (GSDMD). However, the roles of inflammasomes in different stages of viral infection remains mainly unclear. More proper experimental models of viral hepatitis should be developed for specific studies in future, so that we can understand more about the complexity of inflammasome regulation and multifunction of inflammasomes and their downstream effectors during HBV and HCV infections.
The following relates to medical device technology. In one aspect, the score is calculated based on vital sign information of the patient. The scores are shown in the center circle. Spokes corresponding to respective vital signs may extend from the central circle. The spokes may be color coded based on their corresponding sub-scores (e.g., severity) of the vital signs. The thickness of each spoke may be based on the sub-score of the corresponding vital sign.
The subjects in the control group receive educational intervention by a dental hygienist in accordance with conventional routines (oral health information and oral hygiene instruction at one or several occasions). Follow up are performed at 6- and 18-months.