Mental health care for clients with a migratory background (CMB) is less effective than for clients without a migration background. For instance, CMB show higher rates of dropout, have longer care trajectories, show lower treatment effects, and are more frequently forced into clinical care. Part of the explanation for this might be higher thresholds to seek help and treatment mismatches due to a lack of adaptation of the diagnostic and treatment methods to the client's needs. Despite the positive fact that CMB have more frequently sought help over the past years, the drop-out remains high because CMB care needs are often not met. To make amends for this problem, the need for clinical instruments emerged to clarify the influence of cultural aspects in diagnostics. This led to the first draft of the Cultural Formulation Interview (CFI), which was added to the DSM-5, aiming for clinicians to gain more insight into the illness perspectives of CMB when using the instrument. This semi-structured interview contains 16-17 questions that aim to bridge gaps between differences in cultural referential frameworks of CMB and clinicians which may improve healthcare for CMB. The CFI enhances communication about culture, which increases mutual understanding and rapport based on interest and better apprehension of the client's cultural background aiming to prevent cultural misunderstandings. Research shows that the use of the CFI positively influences communication between CMB and clinicians. Empathy is crucial in this communication because an empathic clinician will better understand the client's problems and come up with more adequate diagnoses, which benefit the CMB.

Empathy refers to the emotional and cognitive reactions to the observed experiences of someone else. Empathy is defined as the accurate acknowledgment of the internal reference framework of another person integrated with the emotional components and implication to be the other, by putting oneself into someone else's position. Empathy is an important ingredient for building relationships between clients and clinicians. This is even more important when practicing effective culture-sensitive psychotherapy. Cultural empathy is the capacity to identify with the feelings, thoughts, and behavior of people with a different cultural background than one's own by listening and hearing beyond spoken words and bridging cultural differences. The level of cultural empathy can influence the strength and quality of a therapeutic relationship, which is also known as work alliance. The strength of a working alliance depends on the level of agreement with the treatment goals and given tasks within the therapy, and the affective quality of the relationship between the CMB and the clinician.

In an exploratory qualitative study during the implementation phase of the CFI-test version, tentative optimistic signs regarding satisfaction and clarity were found, whilst an earlier study reported resistance against the implementation of the CFI from both CMB and clinicians' perspectives. No research has been done to examine CFI use concerning work alliance and cultural empathy. The need to perform a random controlled trial (RCT) emerged because part of the CFI questions was experienced as problematic. Despite previous findings, it is expected that using the CFI with CMB strengthens the working alliance between CMB and clinicians, either mediated or moderated by cultural empathy. Outcomes could help to improve mental healthcare by stronger work alliance and lower drop-out rates through better communication, understanding, and empathy between CMB and clinicians.

This study empirically investigates whether using the CFI increases the clients' and informant's sense of being understood within their cultural context, and thus encounter cultural empathy and whether due to perceived cultural empathy they experience a stronger working alliance with their clinician. Outcomes might convince clinicians of the usefulness and relevance of the structural use of the CFI in clinical practice, especially when this proves to increase perceived (cultural) empathy and strengthen work alliance. It is expected that a culture-sensitive working alliance between CMBs, informants, and clinicians could be a crucial aspect in reducing the high drop-out and relatively low effect on mental health care for first and second-generation migrants. The central research question in this study is: To what extent do the use of the CFI for CMB and their informants change their work alliance with clinicians? This change could be moderated (changed in strength and direction) or mediated (explained) by cultural empathy. It is hypothesized that the use of the CFI will improve the therapeutic working alliance moderated (strengthened) by cultural empathy.