anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND AIMS: Abnormal liver chemistries are common in Turner syndrome (TS). Guidelines suggest that TS patients undergo annual screening of liver enzymes, but the role of non-invasive screening for steatosis and fibrosis is not clearly defined. We compared the prevalence of hepatic steatosis and fibrosis among TS patients to healthy controls using ultrasound with shear-wave elastography (SWE) and assessed for risk factors associated with steatosis and fibrosis in TS.
METHODS: Prospective case-control study of TS versus control patients from 2019 to 2021. All patients underwent abdominal ultrasound with doppler and SWE to assess hepatic fibrosis and steatosis. Risk factors were compared between TS and controls, as well as within the TS group.
RESULTS: A total of 55 TS and 50 control patients were included. Mean age was 23.6 years vs. 24.6 years in the control group (p = .75). TS patients had significantly more steatosis (65% vs. 12%, stage 1 vs. 0, p < .0001) and fibrosis (39% vs. 2%, average Metavir F2 vs. F0, p < .00001) than controls. These findings remained significant after adjusting for body mass index (BMI) (p < .01). GGT is more sensitive than AST or ALT in identifying these changes.
CONCLUSION: TS is associated with an increased prevalence of hepatic steatosis and fibrosis compared to healthy controls. Our findings suggest that serum GGT and ultrasound with SWE may help identify TS patients with liver disease. Early risk factor mitigation including timely oestrogen replacement, weight control, normalization of lipids and promoting multidisciplinary collaboration should be encouraged.
Measurements of resistance to embolism suggest that Cupressus sempervirens has a stem xylem that resists embolism at very negative water potentials, with 50% embolism (P50) at water potentials of approximately -10 MPa. However, field observations in a semi-arid region suggest tree mortality occurs before 10% embolism. To explore the interplay between embolism and plant mortality, we conducted a controlled drought experiment involving two types of CS seedlings: a local seed source (S-type) and a drought-resistant clone propagated from a semi-arid forest (C-type). We measured resistance to embolism, leaf relative water content (RWC), water potential, photosynthesis, electrolyte leakage (EL), plant water loss, leaf hydraulic conductivity, and leaf non-structural carbohydrate (NSC) content during plant dehydration and before rewatering. All measured individuals were monitored for survival or mortality. While the S- and C-types differed in P50, transpiration, and mortality rates, both displayed seedling mortality corresponding to threshold values of 52-55% leaf RWC, 55% and 18.5% percent loss of conductivity (PLC) in the xylem, which corresponds to 48% and 37% average EL values for S and C types, respectively. Although C-type C. sempervirens NSC content increased in response to drought, no differences were observed in NSC content between live and dead seedlings of both types. Our findings do not fully explain tree mortality in the field but they do indicate that loss of membrane integrity occurs before or at xylem water potential, leading to hydraulic failure.
Most pain relief products on the market, if they work at all are labeled “for temporary relief”. A person in pain for whatever reason desires three things. Since pain is not enjoyable, quick action is the first. For the same reason, long lasting is the second. The third consideration is as safe a product as possible. “Pearl Blue” performs all these needs quite well. The lidocaine is quick, begins relief in some degree in minutes. The other 6 ingredients penetrate at different rates so that as one diminishes the others in succession are working down the time chart to bring their own individual relief for up to 3 hours or longer depending on the sufferers own body chemistry. And the ingredients work together to aid each other in the whole result and have been time tested individually to be safe for generations.
Postoperative pulmonary hypertension (PHT) is the most challenging complication of valvular heart disease about 73% of the patients particularly in those posted for mitral valve replacement surgery Methods This prospective study was conducted in 120 patients aged from 54-65 years scheduled for elective valve replacement surgeries. Patients were randomly allocated to either nitro glycerine or PGI2 groups. Patients of nitro glycerine group received nebulized nitro glycerine (its starting concentration was 200 mcg/ml); nitro glycerine was delivered at a rate of 2.5-5 mcg/kg/min (5 mg, 1 mg/ml) over 10 minutes by ultrasonic nebuliser connected to the inspiratory limb of the breathing circuit. Patients of PGI2 group received nebulized PGI2 (epoprostenol), 20000 ng/ml (20000 ng/ml in 60 ml syringe was attached to an intravenous pump which delivers a titrating rate of 8 ml/h to the nebulizer compartment. The primary outcome was mean pulmonary artery pressure. The secondary outcomes included mean arterial blood pressure (MAP) (mmHg), PaO2/FiO2 ratio, cardiac index (CI) (l/min/m2) right ventricular ejection fraction (RVEF), central venous pressure(CVP) measured at the end of cardiopulmonary bypass then 30 minutes after start of treatment then 4 hours after start of treatment, 30-day mortality rate and the incidence of complications such as facial flushing, hypotension and re-exploration for bleeding.
An electrospinning device is described for producing nanofibrous porous structures. The device comprises three or more neighbouring outlets ( 11 ) separated from one another by a distance of at least 4 cm and positioned in a first plane ( 12 ). The device also comprises a second surface ( 13 ) for receiving output from the outlets. A relative movement between the three or more neighbouring outlets ( 11 ) and the second surface ( 13 ) can be applied in a first direction and second direction, the second direction being substantially perpendicular to the first direction. The second surface ( 13 ) thereby is facing the first plane wherein the outlets are positioned. The device furthermore comprises a voltage source ( 9 ) adapted to apply a potential difference between the first surface and the second surface. It furthermore may comprise a recipient for containing a solution or melt to be electrospun from the outlets and comprises a providing means for providing ( 10 ) the solution or melt to the outlets. The present invention in one aspect also relates to a teeth whitening system for whitening teeth. The system is based on a nano-fibrous structure for applying to the teeth and also comprises a teeth whitening moiety comprising a bleaching agent. The use of the nano-fibrous structure allows the use of a low viscosity teeth whitening moiety, a good fit of the structure over the teeth, thus allowing to treat the tips of the canine teeth and sticking the device to the teeth whereby the preferred shape of the device when in use can be maintained. The present invention also relates to a corresponding nano-fibrous structure and a method for bleaching teeth.
Physicians are exposed to high stress and strain that results in burnout, affecting not only them, their families, patients, but the whole healthcare system. Thus there is an urgent need to develop methods to increase resiliency of physicians. A comprehensive yoga breathing and meditation-based online program (Sudarshan Kriya Yoga, or SKY) is a potential approach to mitigate physician burnout. This is a randomized clinical trial assessing the potential efficacy of SKY compared to a stress management education (SME) training as control, conducted online. Both groups received training for three consecutive days, 1,5 hours per day, through group video conference. Active physicians participated in the study from November 2021 to March 2022. Of the 280 physicians who showed interest and prescreened, 238 were eligible and randomized to receive either the SKY or the control intervention.
A comprehensive systematic review was published showing the efficacy and effectiveness of Systemic Psychotherapy in treating the most common psychological disorders. It is important to critically evaluate Systemic Psychotherapy to identify the most promising paths forward. One such promising path lies in online self-help interventions (OSIs). OSIs can be broadly divided into guided and unguided modes of self-help, with the former showing better efficacy than the latter. This distinction notwithstanding, unguided OSIs have been shown to be effective in the treatment of anxiety, depression, the prevention of suicides, and numerous other psychological disorders and conditions. From a public health perspective, OSIs are particularly interesting as they promise to address several obstacles to conventional mental health care provision and harness patients' capacities for self-help. Additionally, their scalability might facilitate the provision of services to target groups that could otherwise not be reached. Platforms such as "7 Cups" (https://www.7cups.com), which provides OSIs (called Growth Paths), text-based paraprofessional peer support, paraprofessional training (called Listener Training), and signposting to professional services, have been identified as particularly effective in incorporating this approach. Platforms such as 7 Cups, whose peer support programme has received some attention, warrant further scrutiny. While it is acknowledged as an important part of improving access to mental health care globally, there is only one published study on an OSI explicitly incorporating methods and techniques associated with Systemic Psychotherapy and no studies examining paraprofessional training in a widely accessible online platform such as 7 Cups. This exploratory study aims to make a timely and meaningful contribution towards the gaps in the current literature.
This study evaluated the performance characteristics, construct validity, and reliability of two computerized, self-administered verbal and visual recognition memory tests based on the Remember-Know paradigm. Around 250 healthy control participants and 440 patients referred for neuropsychological assessment used an iPad to complete the Words and Faces recognition memory tests before or after concurrent neuropsychological testing. Performance accuracy was high but without ceiling effects. Education, but not age, was related to overall performance for both samples while the influence of gender and race differed across samples. In the clinical sample, overall performance was worse in those patients demonstrating memory impairment on clinical assessment. Words and Faces subtests demonstrated the strongest correlations with neuropsychological measures of verbal and nonverbal memory, respectively. Both showed moderate correlations with processing speed while Faces was also correlated with visuospatial skills. The memory tests showed good test-retest reliability over two testing sessions. These findings demonstrate acceptable psychometric properties in clinical and community samples and suggest that this computerized format is feasible for memory assessment in clinical contexts.
Duloxetine delayed-release capsules are indicated for the treatment of generalized anxiety disorder (GAD). The efficacy of duloxetine was established in three short-term trials and one maintenance trial in adults [see ]. Duloxetine delayed-release capsules are indicated for the treatment of generalized anxiety disorder (GAD). The efficacy of duloxetine was established in three short-term trials and one maintenance trial in adults [see CLINICAL STUDIES (14.2) ]. 

Generalized anxiety disorder is defined by the DSM-IV as excessive anxiety and worry, present more days than not, for at least 6 months. The excessive anxiety and worry must be difficult to control and must cause significant distress or impairment in normal functioning. It must be associated with at least 3 of the following 6 symptoms: restlessness or feeling keyed up or on edge, being easily fatigued, difficulty concentrating or mind going blank, irritability, muscle tension, and/or sleep disturbance.Generalized anxiety disorder is defined by the DSM-IV as excessive anxiety and worry, present more days than not, for at least 6 months. The excessive anxiety and worry must be difficult to control and must cause significant distress or impairment in normal functioning. It must be associated with at least 3 of the following 6 symptoms: restlessness or feeling keyed up or on edge, being easily fatigued, difficulty concentrating or mind going blank, irritability, muscle tension, and/or sleep disturbance.
The present disclosure relates to a facial mask sheet, a facial mask component and a manufacturing process of facial mask thereof, and relates to the field of cosmetics package. The structure of the existing facial mask sheet is optimized. The facial mask sheet includes a main body and protrusions. The main body is provided with eye holes and a mouth hole, and the eye holes and the mouth hole are symmetrically arranged with respect to a vertical center line of the main body. A plurality of protrusions are arranged along the edge of the main body, and the plurality of protrusions are asymmetrically arranged with respect to the vertical center line. With respect to the facial mask sheet with the above structure, the facial mask sheet can be easily unfolded, thus improving the convenience of use, and meanwhile avoiding the migration of potentially harmful substances such as heavy metals, fluorescent agents, pigments and the like onto the mask cloth, resulting in harm to the skin when the facial mask is used.
This is a Phase 2, Open-Label Study to Evaluate the Safety, Efficacy and Systemic Exposure of VP-102 Topical Film Forming Solution \[0.7% (w/v) cantharidin\] in subjects 2 years and older with Molluscum Contagiosum. Up to 40 subjects will be enrolled in the study with the goal of 16 meeting criteria for, and completing all scheduled blood draws outlined in the exposure portion of the trial. Subjects that do not have enough molluscum lesions to participate in the exposure study but do meet all other criteria to participate in the study will be enrolled in the standard treatment group. No more than 16 subjects will complete exposure group activities; up to 16 subjects will be enrolled in the standard treatment group. The additional 8 subjects may be used for replacement patients. At least 3 patients in the exposure group will be from 2-5 years of age. All subjects will receive VP-102 containing 0.7% cantharidin to molluscum lesions every 21 days for a maximum of 4 sessions or until complete clearance.

In the exposure group, blood samples for systemic exposure evaluation will be collected on Day 1, prior to the drug application, and 2 (± 30 minutes), 6 (± 1 hour) and 24 (±3 hours) hours post-application. A dermatological examination will be performed by a qualified investigator quantifying molluscum lesion counts at every study visit.
PURPOSE:To provide a platelet aggregation-inhibiting agent containing a prostaglandin E1 analogue as an active ingredient, excellent in its medicinal effect, good in durability, and not inducing the diarrhea of adverse action. CONSTITUTION:The platelet aggregation-inhibiting agent contains a compound of the formula (R is H, 1-6C alkyl) or its salt, e.g. (2E,16RS)16,20- dimethyl-2,3,13,14,18,18,19,19-octadehydro-prostaglandin E1-methyl ester as an active ingredient. The agent can be prepared in the form of tablets, granules, capsules. solution, emulsion, injection, suppositories or pessaries. The agent is administered at a dose of 0.1-100mug once to three times a day. The agent is useful for treating and preventing thrombotic diseases, and further useful for treating peripheral arterial obstruction because of its having an angiectatic action.
PURPOSE: A composition for protecting liver and improving liver functions is provided to prevent damages to liver, and to promote the restoration of liver cells. CONSTITUTION: A composition for protecting liver and improving liver functions contains a milk thistle extract, S-adenosylmethionine, and non-essential amino acid. The non-essential amino acid is selected from alanine, aspartic acid, glutamic acid, glycine, proline, arginine, cysteine, tyrosine, and serine. The milk thistle extract is extracted by using water, ethanol, or a mixture thereof. A non-polar organic solvent is hexane. 0.1-10 parts by weight of milk thistle extract is used for the composition.
Obese patients with breast cancer have worse outcomes than their normal weight counterparts, with a 50% to 80% increased rate of axillary nodal metastasis. Recent studies suggest a link between increased lymph node adipose tissue and breast cancer nodal metastasis. Further investigation into potential mechanisms underlying this link may reveal potential prognostic utility of fat-enlarged lymph nodes in patients with breast cancer. This study used a deep learning model to identify morphologic differences in nonmetastatic axillary nodes between obese, node-positive, and node-negative patients with breast cancer. The model was developed using nested cross-validation on 180 cases and achieved an area under the receiver operator characteristic curve of 0.67 in differentiating patients using hematoxylin and eosin-stained whole slide images. The morphologic analysis of the predictive regions showed an increased average adipocyte size (P = 0.004), increased white space between lymphocytes (P < 0.0001), and increased red blood cells (P < 0.001) in nonmetastatic lymph nodes of node-positive patients. Preliminary immunohistochemistry analysis on a subset of 30 patients showed a trend of decreased CD3 expression and increased leptin expression in fat-replaced axillary lymph nodes of obese, node-positive patients. These findings suggest a novel direction to further investigate the interaction between lymph node adiposity, lymphatic dysfunction, and breast cancer nodal metastases, highlighting a possible prognostic tool for obese patients with breast cancer.
OBJECTIVE: The role of elective neck dissection (END) in the management of clinical N0 (cN0) squamous cell carcinomas (SCC) of the sinonasal tract is unclear. In this systematic review, we evaluate the risk of occult nodal metastasis in sinonasal SCCs with cN0M0 tumors to support clinical decision making.
METHODS: A literature search was conducted in the following three electronic databases: Medline/PubMed, ScienceDirect, and Google Scholar. Articles were assessed for eligibility in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Two independent authors extracted the data. The Methodological Items for Non-Randomized Studies (MINORS) tool was used for the assessment of biases of each included study.
RESULTS: Our systematic review included six studies that met the inclusion criteria, all retrospective in design. The rate of histologically proven metastasis of sinonasal SCC to the clinically negative neck is 12.5%. Almost half of the positive cases are pathologically staged as N2 (6.5%).
CONCLUSION: Our systematic review provides the rate of sinonasal SCC occult metastasis to the neck so that the surgeons can discuss with patients the risks and possible merits of adding an elective neck management in the surgical plan.
The present invention provides a method of manufacturing tablets. An example of the method involves preparing a placebo blend containing only excipients. This placebo blend is compressed into tablets having concavities such as pinholes or indentations. Separately, a dispersion containing an active pharmaceutical ingredient, a drug, or a drug substance is prepared. A predetermined amount of this dispersion is placed into those concavities, and the tablets are dried. In this method, an active ingredient is handled in the form of a dispersion rather than as a solid. In addition, once the tablets are dried, the active ingredient is trapped inside the concavities and remains unexposed to external physical friction. As a result, human contact with powders or dust of active ingredient during the manufacturing and shipping processes may be minimized in a cost-effective manner. The present invention is also directed to the tablets prepared by this method.
PURPOSE: Provided is a cosmetic composition including a plant extract containing abscisic acid and a derivative thereof which inhibit hyperkeratosis or hyper-desquamation by controlling the growth of skin fibroblasts while improving skin appearance. Therefore, the composition has no irritation, reduces skin wrinkles, improves aged skin and provides skin transparency to the skin. CONSTITUTION: A cosmetic composition for improving skin appearance contains 0.00001 to 1% by weight of abscisic acid and a derivative thereof represented by the formula 1 as an active ingredient, based on the dried weight. In formula, R is H or CH3. The abscisic acid and a derivative thereof are in the form of an extract of a plant selected from the group consisting of Narcissus tazetta L. var. chinensis Roem., Arabidopsis thaliana, avocado, Lycopersicon esculentum or Pisum sativum L. The cosmetic composition further contains a skin softening agent, a wrinkle removing agent, a skin whitening agent or an antioxidant.
Participants in Cohort B whose injected lesions achieved partial response or complete response by week 26 and who did not experience any serious adverse events, are permitted to receive additional injections up to 4 residual KS lesions (total volume 10 mg in 1 mL) every 2 weeks for up to 4 additional doses. Lesions will be assessed again after 26 weeks.
The invention relates to a medical pillow which comprises a pillow inner and a pillowcase wrapped outside the pillow inner. The innovation point is that the pillow inner is filled with the components in parts by weight as follows: 4-5 parts of radices trichosanthis, 4-6 parts of fructus forsythiae, 3-6 parts of honeysuckle, 5-7 parts of root of common peony, 6-8 parts of lophatherum gracile, 4-9 parts of rhizoma alismatis, 4-5 parts of talc, 4-5 parts of rhizoma anemarrhenae, and 4-8 parts of liquorice. The radices trichosanthis, the fructus forsythiae, the honeysuckle, the root of common peony, the lophatherum gracile, the rhizoma alismatis, the talc, the rhizoma anemarrhenae and the liquorice are filled in the pillow inner in proportion. The components exert the efficacy slowly in long time sleep of people. The radices trichosanthis matched with the rhizoma anemarrhenae nourishes yin and purges intense heat, helps produce saliva and slake thirst, and treats polydipsia due to heat disease damaging liquid, as well as lung dryness and yin damage due to heat disease damaging liquid of lung and stomach heat, dry cough and little phlegm or expectoration with blood. The medical pillow has the functions of tonifying lung, collecting qi, cooling, calming the heart, relieving liver depression, slowing liver urgency, clearing bladder heat, stopping pee shot number of heat strangury and eliminating yangming damp and hot. The medical pillow is good in health care effect, and meets the living demand of modern people under heavy pressure and at high pace.