anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The increasing age of liver donors and transplant candidates, together with the growing prevalence of metabolic comorbidities, could impact the risk of vascular complications after liver transplantation. We enrolled a consecutive cohort of adult patients undergoing liver transplantation from 2012 to 2021 who had a blinded pathological assessment of atherosclerosis in the donor and recipient hepatic arteries (HA). Patients receiving partial or reduced grafts, retransplantation, or combined organ transplantation were excluded. The relationship between HA atherosclerosis and HA thrombosis after liver transplantation was evaluated using logistic regression in the whole study cohort and in a propensity score-matched subpopulation. Among 443 eligible patients, 272 had a full pathological evaluation of the donor and recipient HA and were included in the study. HA atheroma was present in 51.5% of donors and in 11.4% of recipients. HA thrombosis occurred in 16 patients (5.9%), being more likely in patients who received a donor with HA atherosclerosis than in those without (10.7% vs. 0.8%; p < 0.001). Donor HA atherosclerosis was an independent risk factor of HA thrombosis (OR = 17.79; p = 0.008), and this finding was consistent in the propensity score-matched analysis according to age, sex, complex arterial anastomosis, and alcoholic liver disease (OR = 19.29; p = 0.007). Atheromatous disease in the recipient had no influence on the risk of HA thrombosis (OR = 1.70; p = 0.55). In conclusion, patients receiving donors with HA atherosclerosis are at increased risk for HA thrombosis after liver transplantation. The evaluation of the donor graft vasculature could guide antiplatelet therapy in the postoperative period.
A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.
Henoch-Schönlein purpura (HSP) is an immunoglobulin A (IgA)-mediated systemic vasculitis, which is one of the rare adverse reactions to hepatitis B vaccination. Low vitamin D levels were found to be present in the majority of HSP patients.A 19-year-old woman was admitted with a purpuric rash on bilateral lower limbs and joint pain on her left index finger in January 2020. A previous history of rash occurred one week after the patient received her first dose of recombinant hepatitis-B vaccination. Routine hematological examination, creatinine, urinalysis, C3, and C4 showed normal results. HBsAg, Anti-HCV, and ANA tests were negative, and anti-HBs were elevated. Vitamin D is very low. The patient was diagnosed with HSP and given mycophenolate mofetil, methylprednisolone, vitamin D3, and folic acid. Within 1 month of therapy, the rash still occurred frequently, so mycophenolate mofetil was changed to mycophenolic acid, the dose of methylprednisolone was increased and fexofenadine was administered. In the next 3 months, the rash has improved. However, patients reported knee joint pain and hair loss. In May 2021, the patient underwent tonsillectomy due to acute exacerbation of chronic tonsillitis. Thereafter, the patient reported that the rash had completely resolved and never worsened, and the vitamin D assay was normal.Hepatitis B vaccination is one of the etiologies of HSP, although it is rare, so it is important to ask about the vaccination history in patients with suspected HSP. Correction of vitamin D and performing tonsillectomy provide better treatment results in HSP cases in this patient.
OBJECTIVES: Optimal sleep is crucial for developing and maintaining gifted children's cognitive abilities. However, only a few studies have explored the sleep profiles of gifted children and overlooked their internal variations. This study aimed to investigate subjective and object sleep profiles in school-aged gifted children with different levels of giftedness.
METHODS: This study included 80 school-aged children (50 % male) aged 6-11 years. Giftedness was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Subjective and objective sleep were evaluated using the Children's Sleep Habits Questionnaire (CSHQ) and Actiwatch 2.
RESULTS: The sample was divided into three groups based on their full scale intelligence quotient (IQ): 16 typically developing children (IQ < 130), 38 moderately gifted children (IQ: 130-145), and 26 highly gifted children (IQ > 145). The highly gifted children had the mildest sleep problems, particularly in sleep duration and daytime sleepiness. Moderately gifted children had the shortest subjective average sleep duration, while the three groups had no significant differences in Actiwatch-measured sleep variables. Furthermore, CSHQ total and daytime sleepiness subscale scores were negatively associated with the full scale IQ in gifted children after controlling for confounders including emotional and behavioral problems.
CONCLUSIONS: Children with higher levels of giftedness experience fewer subjective sleep problems but have similar objective sleep parameters. It is imperative to implement tailored sleep strategies for fostering intellectual development and nurturing young talents.
Participants receive the CONNECTing to LungCare intervention, including education about the benefits and risks of LCS and the importance of shared decision making, computerized assessments of the participant's smoking status, readiness to quit and concerns about quitting, and video segments tailored to the participant's responses to assessment questions, prior to their primary care appointment. Participants and their providers receive a tailored summary of the participant's concerns and barriers to quitting to enhance motivation for smoking cessation and shared decision-making discussions. Participants then receive up to 3 follow-up phone calls over 10-15 minutes each encouraging them to follow up with their provider, to complete the shared decision-making conversation, obtain LCS if appropriate, and access smoking cessation resources. Participants may also receive brief, tailored follow-up text messages that include links to video segments or cessation resources 1-3 times weekly.
BACKGROUND: Humeral shaft fractures account for up to 3% of all fractures, but complex forms of those fractures (type AO/OTA B or higher) are rare. Plate and screw fixation of the fracture are rated as consolidated from 80 to 97%. Reported complications include non-union, secondary radial nerve palsy and infection. Minimally invasive plate osteosynthesis (MIPO) should provide the same union rate as open reduction and internal fixation (ORIF) but potentially with fewer complications. The aim of our study was to review patients treated for complex humeral fractures with ORIF through an extended delto-pectoral approach using a long pre-contoured locking plate. The morbidity of the open approach, complication rates, union rate and clinical outcomes were assessed.
METHODS: We performed a retrospective analysis of 26 consecutive complex humeral shaft fractures (7 males, mean age 59 years; 19 females, mean age 67 years) treated in our institution with a long pre-contoured locking plate between June/2011 and December/2017. Fracture healing was evaluated with standard radiographs. Eventual complications and the morbidity of the approach were assessed through chart review. The final clinical outcome and quality of life were assessed via telephone interview with DASH score and EQ-5D-3 L in 25 of the 26 patients included.
RESULTS: There were no complications related to the open approach with uneventful wound healing in all cases without any infections. Mechanical complications occurred in 3 cases (11%): one tuberosity dislocation (revised) and two plate failures (one revised). Postoperative radial nerve palsy was observed in two patients (7%), of which one was transient, the other was persistent. The plate was removed in 4 cases (15%). The average radiological and clinical follow-up was 21 months (range: 12-56). At 12 months follow-up complete fracture healing was confirmed in 22 out of 26 cases and in three more patients after 18 months. After an average of 44 months, the mean DASH score was 35 (SD ± 15.83) points; the EQ-5D-3 L score 0.7 (SD ± 0.31).
CONCLUSION: ORIF with a long locking plate though an extended delto-pectoral approach is certainly still a viable option to treat complex humeral shaft fractures with good soft tissue and bone healing as well as good functional recovery. No increased morbidity was attributed to the open surgical approach. In our series, radial nerve palsy could not be completely avoided, accentuating the potential risk of this specific fracture in close proximity to the radial nerve.
TRIAL REGISTRATION: Ethics Committee: Ethikkommission Ostschweiz (EKOS), Project ID: 2019-00323.
The invention belongs to the field of biomedical technology, and in particular relates to a diagnostic and therapeutic gastric cancer vascular specific isotope-labeled short peptide probe <99>TC<m>-GEBP11 or <131>I-GEBP11 and a preparation method thereof. The probe is characterized in that the diagnostic isotope <99>Tc<m>O4<-> or therapeutic isotope <131>I is connected to GEBP11 short peptide, so that the short peptide probe is endowed with double functions of gastric cancer vascular targeting and diagnosis or therapy. In-vivo tracer experiments of the isotope show that the GEBP11 isotope probe has the characteristics of good in-vivo gastric cancer tissue targeting and specific distribution. SPECT imaging of <99>Tc<m>-GEBP11 in a gastric cancer bearing nude mice excellently shows a lesion site of transplanted tumor, and the ideal imaging time interval is within 18 to 24 hours after the injection. Results of tumor-suppressing experiments show that <131>I-GEBP11 has obvious effects of suppressing tumor growth and prolonging life time of the tumor bearing mice and weak toxic or side effect. The GEBP11 isotope probe has certain theoretical significance and great potential application value in gastric cancer diagnosis, vascular targeting therapy and evaluation of therapeutic effect and the like.
The relationship between cerebral oxygenation and blood pressure in patients undergoing hypotensive epidural anesthesia has not been completely elucidated. Previous publications have demonstrated a low incidence of post-op cognitive dysfunction in patients undergoing hypotensive epidural anesthesia for total hip replacement (1-3) and that cerebral blood flow velocity is preserved as measured by transcranial Doppler (4). An earlier investigation by Dr. Yadeau demonstrated infrequent cerebral oxygen desaturation in spontaneously breathing patients undergoing shoulder arthroscopy, even in the presence of hypotension (4), but did not investigate outcomes in the cognitive domain or have a control group of patients undergoing surgery with general anesthesia. There has only been one study looking at cerebral oxygenation and hip surgery, which was performed in elderly patients with fractures. It demonstrated that patients with low pre-op regional cerebral oxygen saturation (rSO2) had higher incidence of delirium (5) but many of those patients had surgery under general anesthesia. Given the costs associated with post-op delirium, cognitive dysfunction and stroke (6) and based on the fact that previous publications from this institution have demonstrated both a low incidence of cognitive dysfunction and preservation of cerebral blood flow velocity using this anesthetic technique, we hypothesized that cerebral oxygen desaturation will not occur in this population.
PROBLEM TO BE SOLVED: To obtain a molding die which is free from its deformation even when it is repeatedly used and is highly durable and pliable and further, is oil-resistant by using the molding die made of a resin containing a fluoroelastomer with a specific fluorinated polyester skeleton. SOLUTION: A fluoroelastomer which becomes a material for an elastic molding die is an elastic resin material obtained by polymerizing (A) an amide compound containing fluorine represented by formula I (wherein, R1 and R2 are a univalent hydrocarbon group) and (B) an organohydrogen siloxane containing fluorine. In the formula I, Q is formula II or formula III. (In the formula II, R3 is a divalent hydrocarbon group in which one or two kinds or more selected from an oxygen atom, a nitrogen atom or a silicon atom may be made to intervene.) (In the formula III, R4, R5 are a divalent hydrocarbon group.) (In the formula I, Rf is a perfluoroalkylene group; and a is an integer of 0 or higher).  The elastic molding die thus obtained is highly pliable, oil- resistant and durable and further, can be repeatedly used many times, so that the molding die is suitable for molding an oily solid decorative material.
Argon plasma coagulation (APC) is a noncontact form of electrocautery. Following randomization, subjects will undergo treatment with either DPT or APC. Subjects will then have six additional study visits at 30, 45, 60, 90, and 180 days after their last PDT or APC treatment.
Purpose: Laparoscopic cholecystectomy (LC) has become the standard treatment for gallbladder surgery due to its advantages over open surgery. However, postoperative ileus (POI) remains a common complication. Gum chewing has been proposed to stimulate bowel function post-surgery, but it's unclear whether xylitol in gum influences outcomes. Our objective was to evaluate the effects of postoperative xylitol gum chewing on gastrointestinal functional recovery after laparoscopy.

Design: A Three-Arm Randomized Controlled Trial Methods: Altogether, 75 patients undergoing elective laparoscopy cholecystectomy were randomly divided into 3 groups (final numbers, xylitol chewing gum: 24 controls, xylitol free chewing gum:25 and control 25 patients). Controls underwent a routine postoperative regimen. Both groups chewed gum 3 times a day except the control group. Other postoperative management was routine. The first flatus, first bowel movement, first defecation, first mobilization time, and discharge time from the hospital were recorded. Symptoms included nausea and vomiting.
PROBLEM TO BE SOLVED: To obtain an extract from grape seeds which shows inhibitory activity against tyrosinase and is useful as a tyrosinase inhibitor effectively controlling melanin by extracting grape seeds with water and/or an organic solvent. SOLUTION: This extract is obtained by extracting grape seeds with water and/or an organic solvent. As the organic solvent, ethanol, methanol or acetone is favorable. Further, the powder of grape seeds is preferably extracted with an organic solvent of a concentration of 70-80 % under the condition of hot water or heating. This extract is preferably administrated at a dosage of 25-200 mg a day per an adult. This extract may be used as an active ingredient in cosmetics which control melanin formation, prevent skins from aging, protect skins and possess skin-whitening function, an active ingredient in pharmaceutical compositions for treating hyperpigmentation including stain, freckle, spot or superpigmentation in gravidism or an active ingredient in food additives for controlling the browning of foods including fruits, vegetables and perishables.
Embodiments of the present disclosure pertain to methods of selecting cyclic peptides that bind to a target by transforming a phage display library with a plurality of nucleic acids into bacterial host cells, where the nucleic acids include phage coat protein genes with a combinatorial region that encodes at least one cysteine and at least one non-canonical amino acid. The transformation results in the production of phage particles with phage coat proteins where the cysteine and the non-canonical amino acid couple to one another to form a cyclic peptide library. Phage particles are then screened against the desired target to select bound cyclic peptides. Amino acid sequences of the selected cyclic peptides are then identified. Additional embodiments pertain to methods of constructing a phage display library that encodes the cyclic peptides. Further embodiments of the present disclosure pertain to the produced cyclic peptides, phage display libraries and phage particles.
Maryam's flower will place in a bowl of water and left in the room of the pregnant women who will at 1 cm cervical dilatation and in the first phase of the labor. It will explain to the pregnant women that the leaves of the plant would open up in the water, and they will ask to imagine that the birth canal would simultaneously open up. In effect, they will told to focus on the opening of these leaves during the course of the labor.. After birth, the flower used only as a focusing method will be removed from the water and its water will be poured.
Postoperative feeds are initiated on first postoperative day and advanced in using a standardized protocol that best-reflects current feeding practice. Maximum feeding volume is reached at 60 hours.
The invention relates to an eichhornia-crassipes conditioning paste for onychomycosis. The conditioning paste is prepared by employing wild medicinal materials, such as eichhornia crassipes extractive, scutellaria baicalensis extraction liquid, cortex phellodendri extraction liquid, sophora flavescens extractive, fructus cnidii extractive and fructus kochiae extractive, and propylene glycol, glacial acetic acid and the like as main compositions and employing a current technology for elaborate processing. The conditioning paste is applicable to condition and maintain acne and other skin problems. The technology belongs to the field of medicine and hygiene. The technological principle comprises that natural Chinese herbal medicines are carefully chosen and are subjected to compatibility according to an ancient prescription; the sovereign, minister, assistant and courier principle is employed, tests are performed repeatedly, the compositions are elaborately matched, and the conditioning paste is processed according to an ancient method, and the conditioning paste is powerful in drug effect and does not contain any factors harmful to human body. Proper amount of the onychomycosis conditioning paste is gotten and applied to an affected position, the nail is softened, and the conditioning paste rapidly penetrates the affected position and directly acts on the ridus. The effective compositions are rapidly aggregated on the nail bed, and the conditioning paste gives play to effects of clearing heat and detoxifying, diminishing inflammation and killing bacteria, and recovering the nail bed environment, and helps the patient to release trouble of onychomycosis.
Pyridostigmine bromide tablets, USP are an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is:

Pyridostigmine bromide, USP is a white or almost white crystalline, deliquescent powder. It is very soluble in water and in alcohol, slightly soluble in hexane, practically insoluble in ether.

Each pyridostigmine bromide tablet, USP intended for oral administration contains 60 mg of pyridostigmine bromide, USP. In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, low substituted hydroxypropyl cellulose, silicon dioxide and stearic acid.
The invention discloses a microcapsule wrapping a solid sun-screening agent, a preparation method and application thereof. The microcapsule comprises the solid sun-screening agent and a natural polymer. The solid sun-screening agent is wrapped in the microcapsule formed by the natural polymer. The solid sun-screening agent is an inorganic ultraviolet screener, an organic ultraviolet adsorbent or a mixture of the inorganic ultraviolet screener and the organic ultraviolet adsorbent. The natural polymer is agar, agarose, cellulose, chitosan or a derivative thereof. The microcapsule provided by the invention can be used in cosmetic to effectively prevent the solid sun-screening agent from being decomposed, and the sun-screening agent is separated from skin, so that irritation to skin is reduced. Hydrophilic natural polymer can cover color, improve feel and enhance cooperation in cosmetic.
OBJECTIVE: The objective of this study was to identify risk factors associated with surgery-related neurological morbidity in patients with drug-resistant epilepsy undergoing suprasylvian operculoinsular resections. As secondary outcomes, we also analyzed the risk factors for ischemic lesion (IL) of corona radiata and seizure recurrence.
METHODS: A retrospective analysis was conducted on a cohort of patients who underwent suprasylvian operculoinsular resections for drug-resistant epilepsy. The association of several presurgical, surgical, and postsurgical factors with both primary (persistent neurological deficits) and secondary (structural abnormalities on postoperative magnetic resonance imaging [MRI] and seizure recurrence) postoperative outcomes was investigated with univariate and multivariate statistical analysis.
RESULTS: The study included a total of 65 patients; 46.2% of patients exhibited postoperative neurological deficits, but only 12.3% experienced persistent deficits. On postoperative MRI, IL in the corona radiata and corticospinal tract Wallerian degeneration (CSTWd) were seen in 68% and 29% of cases, respectively. Only CSTWd was significantly associated with persistent neurological deficits (relative risk [RR] = 2.6). Combined operculoinsular resection (RR = 3.62) and surgery performed on the left hemisphere (RR = .37) were independently associated with IL in the corona radiata. Variables independently associated with CSTWd were the presence of malacic components in the IL (RR = 1.96), right central operculum resection (RR = 1.79), and increasing age at surgery (RR = 1.03). Sixty-two patients had a postoperative follow-up > 12 months (median = 56, interquartile range = 30.75-73.5), and 62.9% were in Engel class I at last outpatient control. The risk of seizure recurrence was reduced by selective opercular resection (RR = .25) and increased by the histological diagnosis of aspecific gliosis (RR = 1.39).
SIGNIFICANCE: This study provides insights into the risk factors associated with surgery-related neurological morbidity, as well as further evidence on the postoperative occurrence of subcortical injury and seizure recurrence in epileptic patients undergoing suprasylvian operculoinsular resections. The findings highlighted in this study may be useful to better understand the processes supporting the increased surgical risk in the operculoinsular region.
Caxxon Biomarkers detection platform contained eight biomarkers: GRP78, COX2, AKT, AKT Thr308, beta-catenin, P-glycoprotein, P38 MAPK, MMP9. By platform, cancer therapy performance and cancer Procession were well monitored. Anticancer pharmaceutical compositions were also well developed by the platform. Anticancer drug were extracted from a herb Boehmeria nivea. Each extract was also demonstrated its effect of decreasing proliferation of the cancer cell-line. Boehmeria nivea extracts were also estimated its function to eight biomarkers of the caxxon platform. An anticancer compound was purified from Boehmeria nivea actone-ester layer. And the structure anf molecular weight of compound was analyze by NMR and mass.
Daily inhaled steroids. Fluticasone 2 puffs inhaled orally twice daily for six months.