anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The treatment group will receive Seprafilm while the control group will not receive Seprafilm. Allocation of patients will be in 1:1 ratio.
Background: Child care program requirements have adopted nutrition and physical activity standards to address childhood obesity, but few studies have examined the effects of these standards in family child care homes (FCCHs). Methods: In a cross-sectional study (2017-2019), the Childcare Home Eating and Exercise study examined self-reported provider characteristics and observed policies and practices related to physical activity and nutrition in FCCHs in South Carolina. Two-sample t-tests were used to compare observed nutrition and physical activity policy, practice, and environment scores in child care homes that participated in versus did not participate in the state's ABC Quality program, which is designed to improve child care and includes policies and practices intended to increase physical activity levels and improve diet quality. Results: Environment and Policy Assessment and Observation results for nutrition and physical activity were 7.5 out of 21 and 11.8 out of 30, respectively, indicating much room for improvement in nutrition and physical activity policies, practices, and environment in South Carolina FCCHs. The study found one difference between FCCHs that did and did not participate in the ABC Quality program; non-ABC homes provided more time for physical activity. Conclusions: Future research should develop ways to strengthen the guidelines and improve the implementation of obesity prevention standards in FCCHs.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to pharmaceutical industry. Method of purification consists in the following: extract is washed with chlorine-containing hydrocarbon and washing is realised by its slurryfication in chlorine-containing hydrocarbon with further mixing of suspension at room temperature during 20-40 minutes, with ratio 1:28-30. Then sediment is separated and dried at temperature 28-32C and residual pressure 12-14 mm Hg during one and a half hours. Medication represents cream, which contains purified by claimed method extract of green tea with 70-75% content of epigallocatechine-3-gallate (EGCG) in amount of 7-40 wt %. Cream is applied on damaged areas of face and body skin in thin layer until complete drying 1-3 times per day during 5 days - 12 weeks. Method of purification makes it possible to obtain extract with high EGCG content and low content of caffeine. ^ EFFECT: obtained cream has expressed antihyperplastic, anti-inflammatory and antioxidant properties, activates natural process of tissues regeneration, normalises metabolic processes, inhibits premature aging processes, increases skin stability against unfavorable impact of environment. ^ 3 cl, 2 dwg, 2 tbl, 12 ex
PROBLEM TO BE SOLVED: To prevent deformation of a suppository by heat even if the suppository is placed in a preserving or flowing process in a temperature environment not less than a body temperature by sealing a filler in a space between the suppository and a container in a suppository packing body composed of the suppository and the container including the suppository. SOLUTION: When manufacturing a suppository packing body 5, first of all, a suppository 1 of a melting state is introduced to a space in a suppository container 2 via a nozzle in a state of opening an inlet 2a of the suppository container 2 vertically upward. At this time, the suppository 1 is not completely filled in the space in the suppository container 2, and is filled up to a height of a certain degree from the bottom part. Afterwards, the suppository 1 is cooled at a room temperature to be solidified. Next, a filler 4 is densely filled in a space remaining in the suppository container 2 via a supply means. Thus, since a recessed sunk-in part of an end part surface generated when solidifying the suppository 1 is also completely filled by the filler 4, a void does not remain in the suppository container 2.
The invention belongs to the technical field of medicines, and particularly relates to a lung fibrosis therapeutic cow milk exosome-siTGF-beta 1 medicine. The efficacy of M-siTGF- β1 was demonstrated in both the bias-2 b cell level and bleomycin-induced mouse lung fibrosis model. M-siTGF- β1 was found to be effective in delivering target siRNA to the lung by tracheal nebulization, resulting in selective gene silencing, inhibition of TGF- β1 protein expression, and epithelial-mesenchymal transition pathway (EMT). The pharmacological and pharmacodynamic results in vitro and in vivo show that M-siTGF-beta 1 reduces infiltration of inflammatory cells, reduces deposition of extracellular matrix and improves survival rate of pulmonary fibrosis mice. M-siTGF-. Beta.1 may represent a potential strategy for treating pulmonary fibrosis.
After taking approval from hospital ethical committee, 272 patients who reported to Operation Theatre of CMH, Jhelum were selected for the study. Informed consent was obtained and patient demographic information (name, age, contact) was recorded. Patients were randomly divided in two equal groups by using lottery method. GROUP A: Where Macintosh laryngoscope was used for endotracheal intubation. GROUP B: Where McCoy laryngoscope was used for endotracheal intubation.

Before reporting to Operation theatre a detailed pre anesthesia assessment was done in all patients, all necessary laboratory investigations were collected. On OT table pulse and systolic blood pressure was checked by non-invasive method. 18G cannula was passed and ECG was attached. A pillow was placed under the head to obtain classical sniffing position for intubation. All the patients were pre medicated with injection midazolam 0.08mg/kg, injection nalbuphine 0.1 mg/kg, injection dexamethasone 0.08mg/kg and injection metoclopramide 0.1 mg/kg. Pre oxygenation was done with 100% oxygen for 3 mins. Induction was done with injection propofol2 mg/kg, muscle relaxation achieved with injection atracurium 0.5mg/kg. Laryngoscopy was started after 3 minutes by a qualified anesthetist. Pulse and systolic blood pressure was recorded by non-invasive measures before laryngoscopy and at 30 seconds, 2 and 3minutes after intubation. All this information was recorded on a Proforma.
The standard warm-up protocol consists of 5 (five) minutes of stationary cycling, followed by calf, hamstring and quadriceps stretching. For all stretching positions 30 (thirty) seconds will be set. For calf stretching, the participant places his hands on the waist and projects his dominant limb behind of the center of mass line, the contralateral limb will be placed forward until the stretch sensation on the dominant limb start. For hamstring stretching, the participant will be instructed to bend over the hip, reaching the foot of the dominant limb in dorsiflexion. Emphasis will be placed on maintaining the heel of the dominant limb on the floor and maintaining posture. Finally, for quadriceps stretching, the participant will perform a knee flexion and will hold the dominant lower limb foot close to the gluteus with the ipsilateral upper limb hand. Emphasis will be placed on maintaining trunk posture.
Prodn. of live mumps vaccine is characterised by the use of the virus strain "Sofia 6". This strain was deposited in the Bulgarian microbial collection at the State Institute for the Control of Medicaments, Sofia, on 7.12.76 under No. 111. It was isolated from patients using guinea-pig neonate kidney cell culture and is attenuated by passage on the same culture. The vaccine is non-reactogenic, immunogenic and epidemiologicall effective. It is stable for =1 year.
PURPOSE: Eugenol is provided to be directly applied onto a lesion and be used as a pharmaceutical composition which selectively treats mechanical allodynia. CONSTITUTION: A pharmaceutical composition for treating mechanical allodynia contains eugenol or a pharmaceutically acceptable salt thereof in a concentration that is lower than the concentration that suppresses VGSCs(Voltage-Gated Na Channels) of a nerve cell. The concentration of eugenol or a pharmaceutically acceptable salt thereof is less than 2 mM. The composition additionally contains a pharmaceutically acceptable carrier. The composition selectively suppresses an HCN channel of the nerve cell. A transdermal formulation for treating mechanical allodynia contains the composition.
Clarity of the cornea is essential for optimal vision. The endothelium is a layer within the cornea that controls its clarity. Fuchs endothelial corneal dystrophy (FECD) is a progressive disease that affects both eyes in which the endothelium is dysfunctional, causing the cornea to swell and lose its clarity. Because of the vision loss associated with this swelling, corneal transplantation is needed for patients with advanced FECD.

Currently, there is no method to directly measure how well endothelium cells are functioning in patients with FECD. Such a measurement, if it were possible, would allow physicians to identify patients who are at a higher risk of corneal swelling. The goal of this study is to establish a tool to measure and compare the amounts of corneal swelling between normal and FECD patients after a stress test is performed (the wearing of an FDA-approved contact lens.) Data will also be collected regarding how quickly and how well a cornea recovers from swelling in patients with healthy eyes compared to those with FECD.
Chimeric antigen receptor T (CAR-T)-cell, an adaptive immune therapy is approved for patients with acute lymphoblastic leukemia and diffuse large B-cell lymphoma. Its use and subsequent toxicities are expected to rise in the coming years. The main toxicities are cytokine release syndrome, hemophagocytic lymphohistiocytosis and immune effector cell associated neurotoxicity syndrome. Cytokine release syndrome is observed in up to 40% of patients. Almost 20% of patient suffer from acute kidney injury after CAR-T cell infusion. Associated factors are high-grade cytokine release syndrome, a prior autologous or allogeneic stem cell transplantation andrequirement of intensive care unit. Several mechanisms may contribute to the occurrence of acute kidney injury after CAR-T infusion: hypoperfusion during cytokine release syndrome, cytokine injury, T cell infiltration, tumor lysis syndrome and sepsis-induced injury. Kidney injury is associated with substantial increase in morbi-mortality.
Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.
Despite existing knowledge of ways to effectively treat postpartum hemorrhage (PPH), lack of resources in rural India has impeded improvement in rates of maternal mortality and morbidity. Most births take place at home, and local auxiliary nurse midwives are not trained or certified to administer injectable uterotonics. Reduction in postpartum hemorrhage may decrease other adverse maternal outcomes such as the need for additional uterotonic agents, blood transfusion, surgical intervention or death. The main hypothesis of the study is that misoprostol administered orally during the third stage of labor will significantly reduce the incidence of acute postpartum hemorrhage. The advantages of misoprostol are: that it is relatively inexpensive, is an oral preparation of 600 mcg with a long shelf life, and does not require refrigeration. One thousand six hundred women giving birth in selected sites in Belgaum District, Karnataka, India will be randomly assigned to misoprostol or placebo. The primary outcome is the incidence of acute postpartum hemorrhage; secondary outcomes include incidence of delayed postpartum hemorrhage and secondary infection; transport to higher-level facility; use of uterotonic agents; blood transfusion; and maternal mortality for 42 days. A nested case-control analysis of women who experience acute severe postpartum hemorrhage, compared to women who do not, will identify socioeconomic, behavioral, cultural, and systems factors associated with postpartum hemorrhage. For purposes of this study, acute PPH is defined as blood loss equal to or greater than 500 ml within 2 hours of delivery and acute severe PPH as blood loss equal to or greater than 1000 ml within 2 hours of delivery.

The sample size was based on a decrease of 50% PPH in the treated versus the control group; 20% rate of non-compliance, power of 96%, and a two-tailed type I error of 0.05
A method of contraception which comprises administrating a combination of 17a-ethinylestradiol and norgestimate for 21 successive days to a female of childbearing age. For the first 7 days in a daily dose of 25mg of 17a-ethinylestradiol and 0.18mg of norgestimate. For the next 7 days in a daily dose of 25mg of 17a-ethinylestradiol and 0.215mg of norgestimate. For the next 7 days a daily dose of 25mg of 17a-ethinylestradiol and 0.25mg of norgestimate. The next 7 days there is no estrogen and progestogen administration. Also described is a triphasic oral contraceptive unit having 21 separate dosage units, each unit containing a combination of an estrogen and a progestogen.
Prospective enrolment of all patients with mitral valve insufficiency and restricted movement of leaflets during systole into a multicentric registry. Exact analysis of the underlying pathology using TTE with analysis of tenting parameters. In patients without contraindications, functional preoperative MRT to determine the functional reserve of ventricular function. Documentation of the quality of life of the patients using the SF12 questionnaire before and after intervention. Documentation of follow-up data (SF12, TTE, NT-pro BNP) at 6 months, 1 and 2 years. Development of operative strategies to improve long-term outcomes in patients with severe LV dilation (typically accompanied by function mitral insufficiency type IIIb).
BACKGROUND: Children who experience chest discomfort, palpitations, vasovagal syncope, and underlying heart disease often present a complex clinical picture. Not only are they dealing with potential cardiac issues, but they may also exhibit behavioral problems that can complicate the diagnostic and treatment process. Moreover, parental acceptance or rejection can significantly influence the child's well-being and medical outcomes in such cases. This study aims to explore the comorbidity of behavioral problems and parental acceptance-rejection in children diagnosed with these cardiac symptoms and underlying heart disease.
METHODS: In a case-control study, the Parental Acceptance - Rejection Questionnaire and Parental version of Strengths and Difficulties Questionnaire (SDQ) was filled by parents of 314 patients from pediatric cardiology clinic.
RESULTS: The control group scored substantially lower overall according to SDQ. The vasovagal syncope subgroup was found to have considerably lower scores on the subscale. The group with chest discomfort scored highly in hostility and aggression in the PARQ. In comparison to the other groups, the vasovagal syncope and chest pain group demonstrated higher scores in undifferentiated rejection and total score.
CONCLUSION: This study showed a correlation between children's behavioral and emotional problems and cardiac symptoms. This states that children's relationship with their parents has an impact on their symptoms. It will be necessary to conduct further studies to determine a causal association and devise preventative measures.
The objective of this diagnostic accuracy study was to develop and validate an alert to identify calves at risk for a diarrhea bout using milk feeding behavior data (behavior) from automated milk feeders (AMF). We enrolled Holstein calves (n = 259) as a convenience sample size from 2 facilities that were health scored daily preweaning and offered either 10 or 15 L/d of milk replacer. For alert development, 132 calves were enrolled and the ability of milk intake, drinking speed, and rewarded visits collected from AMF to identify calves at risk for diarrhea was tested. Alerts that had high diagnostic accuracy in the alert development phase were validated using a holdout validation strategy of 127 different calves from the same facilities (all offered 15 L/d) for -3 to 1 d relative to diarrhea diagnosis. We enrolled calves that were either healthy or had a first diarrheal bout (loose feces ≥2 d or watery feces ≥1 d). Relative change and rolling dividends for each milk feeding behavior were calculated for each calf from the previous 2 d. Logistic regression models and receiver operator curves (ROC) were used to assess the diagnostic ability for relative change and rolling dividends behavior relative to alert d) to classify calves at risk for a diarrhea bout from -2 to 0 d relative to diagnosis. To maximize sensitivity (Se), alert thresholds were based on ROC optimal classification cutoff. Diagnostic accuracy was met when the alert had a moderate area under the ROC curve (≥0.70), high accuracy (Acc; ≥0.80), high Se (≥0.80), and very high precision (Pre; ≥0.85). For alert development, deviations in rolling dividend milk intake with drinking speed had the best performance (10 L/d: ROC area under the curve [AUC] = 0.79, threshold ≤0.70; 15 L/d: ROC AUC = 0.82, threshold ≤0.60). Our diagnostic criteria were only met in calves offered 15 L/d (10 L/d: Se 75%, Acc 72%, Pre 92%, specificity [Sp] 55% vs. 15 L/d: Se 91%, Acc 91%, Pre 89%, Sp 73%). For holdout validation, rolling dividend milk intake with drinking speed met diagnostic criteria for one facility (threshold ≤0.60, Se 86%, Acc 82%, Pre 94%, Sp 50%). However, no milk feeding behavior alerts met diagnostic criteria for the second facility due to poor Se (relative change milk intake -0.36 threshold, Se 71%, Acc 70%, and Pre 97%). We suggest that changes in milk feeding behavior may indicate diarrhea bouts in dairy calves. Future research should validate this alert in commercial settings; furthermore, software updates, support, and new analytics might be required for on-farm application to implement these types of alerts.
Provided is a NFC to customer profile system and method for personalized shopping.  The system includes a mobile NFC reading device comprising a memory and a processor. The memory stores a user profile having constraints and software logic. The system also includes an NFC tag corresponding to an item for sale. The NFC tag comprising item information of the item for sale and located adjacent to or on the item for sale. The mobile NFC  reading device communicates with NFC tag to receive the item information. The processor of mobile NFC  reading device executes the software logic to process the item information and compare the item information with the user profile. The mobile NFC reading device notifies a user in response to a determination that the item information is not within the constraints of the user profile.  Further, the system operates without a network connection.
The invention discloses an application of Houttuynoid A in preparing drugs for treating lung cancer. As a compound, the Houttuynoid A shows high anti-lung cancer activity, can be used for preparing the anti-lung cancer drugs and belongs to the technical field of new uses of the drugs. The Houttuynoid A is capable of remarkably inhibiting non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous cancer cells HTB-8 and human lung epidermoid carcinoma cells QG-5, but is smaller in effect of inhibiting human normal hepatocytes LO2 and peripheral blood lymphocytes, i.e. obvious selectivity is shown. The application of the Houttuynoid A in preparing the drugs for treating the lung cancer is disclosed for the first time. Moreover, the skeleton type of the Houttuynoid A is fire-new, and how strong the inhibitory activity of the Houttuynoid A on the lung cancer cells is unexpected.
BACKGROUND: According to practice guidelines, endoscopic band ligation (EBL) and endoscopic tissue adhesive injection (TAI) are recommended for treating bleeding from esophagogastric varices. However, EBL and TAI are known to cause serious complications, such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from TAI. However, the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage (GOV1) has not been determined. Therefore, the aim of this study was to discover an individualized treatment for mild to moderate GOV1.
AIM: To compare the efficacy, safety and costs of EBL and TAI for the treatment of mild and moderate GOV1.
METHODS: A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also conducted. Patients were allocated to an EBL group or an endoscopic TAI group. The differences in the incidence of varicose relief, operative time, operation success rate, mortality rate within 6 wk, rebleeding rate, 6-wk operation-related ulcer healing rate, complication rate and average operation cost were compared between the two groups of patients.
RESULTS: The total effective rate of the two treatments was similar, but the efficacy of EBL (66.7%) was markedly better than that of TAI (39.2%) (P < 0.05). The operation success rate in both groups was 100%, and the 6-wk mortality rate in both groups was 0%. The average operative time (26 min) in the EBL group was significantly shorter than that in the TAI group (46 min) (P < 0.01). The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group (11.8% vs 45.1%) (P < 0.01). At 6 wk after the operation, the healing rate of operation-related ulcers in the EBL group was 80.4%, which was significantly greater than that in the TAI group (35.3%) (P < 0.01). The incidence of postoperative complications in the two groups was similar. The average cost and other related economic factors were greater for the EBL than for the TAI (P < 0.01).
CONCLUSION: For mild to moderate GOV1, patients with EBL had a greater one-time varix eradication rate, a greater 6-wk operation-related ulcer healing rate, a lower delayed rebleeding rate and a lower cost than patients with TAI.
Participants of NMG performed sciatic, femoral and peroneal nerve and lumbar region gliding. All glides include 4 sets of 10 repetitions, with each gliding cycle lasting 6 seconds, and a 1-minute rest between sets for both extremities.