anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The protocol provides fourth-line experimental treatment for subjects with microsatellite stable (MSS)/ proficient mismatch repair (pMMR) metastatic colorectal cancer. These patients do not respond to checkpoint inhibitors. This study will investigate whether AlloStim® administered weekly in two-21 day cycles with each cycle consisting of 3 weekly intradermal (ID) doses followed the last week with an intravenous (IV) dose (3 cycles =Days 0 through 49) can prime patients to become responsive to checkpoint inhibition immunotherapy. A restaging computed tomography (CT) scan is conducted on day 56 after the priming and will be compared to the baseline CT scan by Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Scans at day 56 are expected to be read as radiological progression upon restaging after AlloStim® priming, possibly due to immunological swelling, known as "pseudoprogression", consistent with the presumed inflammatory mechanism of action of AlloStim®. This mechanism may convert "cold" tumors to "hot" tumors. The immune cell infiltrates of tumors after AlloStim® include T-helper cell type 1 (Th1) memory cells which produce interferon-gamma. Interferon-gamma is known to increase expression of anti-programmed death ligand 1 (PD-L1) checkpoint molecules in the tumor microenvironment. Higher PD-L1 expression may convert checkpoint inhibitor unresponsive tumors to become checkpoint inhibitor responsive. After two 21-day cycles of AlloStim® priming, a combination of AlloStim® IV boosters and anti-PD-L1 checkpoint therapy (with avelumab 800 mg q/2 weeks) is scheduled between days 63 to day 98, A restaging CT scan at day 112 is then compared to day 56 and baseline to determine if the tumor target lesions\' size has changed. An expansion phase providing another cycle of combined AlloStim® and avelumab is provided for stable patients from days 119-154. A final restaging CT scan is conducted on Day 168 for all subjects.
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by multilineage immune dysregulation, which subsequently causes inflammation, fibrosis, and even cirrhosis of liver. Due to the limitation of traditional assays, the local hepatic immunopathogenesis of PBC has not been fully characterized. Here, we utilize single-cell RNA sequencing technology to depict the immune cell landscape and decipher the molecular mechanisms of PBC patients. We reveal that cholangiocytes and hepatic stellate cells are involved in liver inflammation and fibrosis. Moreover, Kupffer cells show increased levels of inflammatory factors and decreased scavenger function related genes, while T cells exhibit enhanced levels of inflammatory factors and reduced cytotoxicity related genes. Interestingly, we identify a liver-resident Th1-like population with JAK-STAT activation in the livers of both PBC patients and murine PBC model. Finally, blocking the JAK-STAT pathway alleviates the liver inflammation and eliminates the liver-resident Th1-like cells in the murine PBC model. In conclusion, our comprehensive single-cell transcriptome profiling expands the understanding of pathological mechanisms of PBC and provides potential targets for the treatment of PBC in patients.
Patients receive docetaxel IV over 60 minutes and carboplatin IV over 30 minutes, or carboplatin alone on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients who have PSA progression or radiographic progression may crossover to Arm B.
DWJ1366 Tab. followed by co-administration of DWC20155 and DWC20156 Tab.
With changes in life environment and the like, people suffering from dry skin have been increasing. In recent years, dry skin is frequently observed too in young women who are liable to excessively eliminate the sebum because of their liking for cleanliness. To treat dry skin, it is needed to moisten the skin. Namely, it is important to maintain moisture in the horny layer due to, among all, lipids (ceramide, etc.) among horny cells. It is intended to provide a method of effectively supplying ceramide which acts as the active ingredient by, in particular, establishing a synergistic effect together with other components to thereby more effectively moisten the skin. This object is achieved by using skin-moistening compositions which contain ceramide and theanine as the active ingredients.
Neuron-specific enolase (NSE) derived from neurons and peripheral neuroendocrine cells is a biomarker for neuroendocrine tumors and for prognostication in comatose cardiac arrest survivors. However, as platelets and erythrocytes contain NSE, hemolysis causes falsely elevated NSE. We used native serum and hemolysate derived from the same patients to make serial dilutions, and subsequently measured NSE (mNSE) and hemolytic index (HI) in each dilution. An algorithm suitable for the laboratory information system was developed based on the mNSE, HI and the estimated gradient of hemolytic interference from 30 patients. We estimated the associated uncertainty of the corrected NSE (cNSE) results based on the observed range of the gradient and derived an equation for cNSE for samples with limited hemolysis (i.e. 5 < HI ≤ 30): cNSE = mNSE - HI × (0.34 ± 0.23) µg/L. By semi-quantitatively grading the contribution from limited hemolysis, a texted result noting the hemolysis-associated degree of uncertainty can accompany the cNSE result. The major challenge of hemolysis when using serum NSE as a biomarker can be managed using an automated algorithm for correction of NSE results based on degree of hemolysis. However, laboratorians and clinicians should be aware of the limitations associated with in vivo hemolysis.
Rinse-off hair care compositions consisting essentially of emulsions of water-insoluble adhesive polymers having a solubility in water at 25  DEG C less than 1.0 % for repairing split ends. Hair rinse compositions, in emulsion or dispersion form, which condition the hair and facilitate setting thereof, include a hair conditioning and emulsifying cationic compound, a water insoluble acrylic or acrylate polymer and a solvent which is a stabilizing and compatibilizing proportion of the composition comprising a higher aliphatic alcohol and/or alcohol ethoxylate, in an aqueous medium. The cationic compound is a quaternary ammonium salt preferably a higher alkyl trimethyl ammonium chloride and the polymer is preferably an acrylamide acrylate copolymer. Preferably, solvents in the compositions are C9-20 aliphatic alcohols and/or C9-20 alcohol ethoxylates having less than 2 ethoxy groups per mole. The preferred emulsion, which is normally of the oil-in-water type, preferably includes propylene glycol and a nonionic surfactant, and the aqueous medium is preferably water, or is essentially water. The invention also includes processes for making and using the invented hair rinse compositions.
Evidence of central nervous system (CNS) exogenous opioid effects in humans has been primarily gained through neuroimaging of three participant populations: individuals after acute opioid administration, those with opioid use disorder (OUD), and those with chronic pain receiving opioid therapy. In both the brain and spinal cord, opioids alter processes of pain, cognition, and reward. Opioid-related CNS effects may persist and accumulate with longer opioid use duration. Meanwhile, opioid-induced benefits versus risks to brain health remain unclear. This review article highlights recent accumulating evidence for how exogenous opioids impact the CNS in humans. While investigation of CNS opioid effects has remained largely disparate across contexts of opioid acute administration, OUD, and chronic pain opioid therapy, integration across these contexts may enable advancement toward effective interventions.
Diet composition of CMNT is a multicomponent Chinese medicinal food, which mainly enriched with whole grains and edible medicine and food homologous (MFH) plants such as Rhizoma Dioscoreae, Momordica Grosvenori, Folium Mori, Radix Puerariae, Fructus lycii, Poria cocos that meets the requirements of a food for special medical purpose. The CMNT group was instructed to consumed the provided CMNT diet consisting of 6 cycles of 5 consecutive days followed by 10 days of ad libitum food consumption. Participants received a 917 kcal/day preprepared human CMNT diet (44.75% carbohydrate, 9.1% protein and 46.15% fat) for 5 consecutive days per cycle. CMNT diet is composed of four ready-to-consume prepared foods including composite nutritional rice, solids beverages, meal replacement biscuit and fruit and vegetable gruel mainly from wholegrains and traditional Chinese medicinal food plants. The intervention lasted for 3 months (6 cycles) and follow-up measurements will be performed in all subjects after 3-months from end of the intervention. The glucose-lowering medication use of participants strictly implemented by their physician according to the diabetes medications management protocol. Treatment-as-usual control group continued to be given standard medication and dietary advice by their physician followed guidelines for the prevention and control of T2D in China.
Upon completion of the 8-week study wait-list period (i.e. their study participation), the opportunity to participate in iCBT, outside the study framework will be provided.
The invention discloses a stable gastrodin crystal with high bioavailability for oral administration as well as a preparation method, a preparation and an application thereof. X-ray powder diffraction analysis, DSC and TG-DTA analysis and HPLC analysis show that the gastrodin crystal is a new crystal form. The preparation method comprises the steps that gastrodin crude products are dissolved with solvents for performing filtering separation, and ethyl acetate is added into the filtering liquid and is crystallized and separated to obtain a target. The preparation is a tablet or a capsule prepared by adding pharmaceutically acceptable carriers and auxiliaries into the gastrodin crystal. The application of the gastrodin crystal is an application of the stable gastrodin crystal with high bioavailability for oral administration in the preparation of medicines for preventing and/or treating cardiovascular and cerebrovascular diseases. The gastrodin crystal is high in purity, stable against light, moisture, heat and the like, high in stability in alkali solutions and high in in-vivo bioavailability; the preparation method is easy to carry out; compared with the existing crystallizing method, the used crystallized solvent has the advantages of less using amount of crystallized solvents, low production cost and easiness for industrial production; moreover, the content is more than 99 percent.
Older adults (i.e. aged ≥60 years) who are physically inactive are at increased risk of falls, functional limitations, disability, and mental health problems. Encouragingly, there is evidence that various physical activity interventions can elicit meaningful improvements in physical function and health-related quality of life in older people. Effective programmes have included aerobic exercise, progressive resistance training and Tai Chi. Yoga is an alternative approach to improving fitness and health outcomes in older adults. The benefits of yoga may be greater than those of exercise alone because yoga offers a combination of physical exercise with mental focus, and participants are taught good posture, self-awareness, and self-care along with relaxation. Indeed, a recent systematic review and meta-analysis that included 16 studies (n=649) concluded that yoga may provide greater improvements in physical functioning and self-reported health status than conventional physical activity interventions in elderly people. However, the previous studies had limitations, including small sample sizes, a single yoga teacher delivering the programme, and short-term follow-up. Furthermore, none of the included studies had been conducted in the United Kingdom. Many different schools of hatha yoga exist in the West, such as Iyengar, Sivananda, Viniyoga, Bikram (Hot Yoga), and it is likely that some of these forms are more acceptable and effective than others in elderly people, many of whom present with multiple morbidities. Gentle Years Yoga© is a yoga programme which was developed in North Yorkshire, England by the British Wheel of Yoga 'Approved Centre' Yorkshire Yoga in 2009 to cater specifically for the needs of older people with age-related conditions such as osteoarthritis, arthroplasty, dementia, sensory impairment. To date, only anecdotal evidence exists regarding the acceptability, feasibility and effectiveness of this programme; therefore, further research is warranted. Here, we are proposing to conduct a two-arm, parallel-group, pilot randomised controlled trial in physically inactive adults aged ≥60 years, the aims of which are to: (i) inform the design of, and assess the feasibility of conducting, a definitive randomised controlled trial, and; (ii) explore the acceptability, safety and potential benefits of the Gentle Years Yoga© programme in this specific population.
The invention belongs to the technical field of animal-borne disease subunit vaccine preparation and relates to preparation and application of the immune protective antigen of the haemophilus parasuis. Outer membrane protein Hbp B genes of the haemophilus parasuis are cloned, a nucleotide sequence is indicated as SEQID NO:1, and the sequence of gene code is indicated as SEQ ID NO:2. Recombination Escherichia coli BL21/Pet-28a-Hbp B (preservation number is CCTCC NO:M2011228) is built and comprises genes in a sequence table SEQ ID NO:1. Antigen protein of the haemophilus parasuis is obtained and expressed through gene transformation Escherichia coli in the SEQ ID NO:1. The invention further discloses a preparation method and application of the recombination Escherichia coli. The haemophilus parasuis subunit vaccine has good safety, and an immune protection effect reaches 83%.
The invention discloses a construction method of a BALB/c-background age-dependent hepatitis B mouse model system and an application thereof. In the model, BALB/c-background replicating form HBV transgenic mice are hybridized with Rag-1 gene knockout mice in the same background, thereby screening adult and young Rag-1<-/-> mice expressing HBsAg. Mouse spleen lymphocytes from wild non-sensitized mice in the same background are transfused back to the adult and young mice, thereby constructing age-dependent acute hepatitis B and chronic hepatitis B mouse models. The model can be used for exploring the cellular and molecular mechanism of virus removal and persistent virus infection and searching a novel target point for immunotherapy of the hepatitis B, thereby screening an anti-hepatitis B medicine. The construction method of the model has good repeatability and significant stability and reliability of detection indices of virology and biochemistry and pathology. The method is reasonable in cost and has good application prospect.
INTRODUCTION: While ample data demonstrate the effectiveness of inpatient psychosomatic treatment, clinical observation and empirical evidence demonstrate that not all patients benefit equally from established therapeutic methods. Especially patients with a comorbid personality disorder often show reduced therapeutic success compared to other patient groups. Due to the heterogeneous and categorical personality assessment, previous studies indicated no uniform direction of this influence. This complicates the derivation of therapeutic recommendations for mental disorders with comorbid personality pathology.
METHODS: Analyzing n = 2094 patients from German university hospitals enrolled in the prospective "MEPP" study, we tested the dynamic interaction between dimensionally assessed personality functioning and psychopathology of anxiety and depression.
RESULTS: Longitudinal structural equation modelling replicated the finding that the severity of symptoms at admission predicts symptom improvement within the same symptom domain. In addition, we here report a significant coupling parameter between the baseline level of personality function and the change in general psychopathology - and vice versa.
DISCUSSION AND CONCLUSION: These results imply that personality pathology at admission hinders the therapeutic improvement in anxiety and depression, and that improvement of personality pathology is hindered by general psychopathology. Furthermore, the covariance between both domains supports the assumption that personality functioning and general psychopathology cannot be clearly distinguished and adversely influence each other. A dimensional assessment of the personality pathology is therefore recommendable for psychotherapy research and targeted therapeutic treatment.
Patients relapsed and/or refractory to HMA therapy receive enasidenib PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
PROBLEM TO BE SOLVED: To obtain the subject powder excellent in water and oil repellencies and homogeneously mixable with other cosmetic oils without causing messy makeup by treating the surface of a powder with a specific silicone compound. SOLUTION: This powder is obtained by treating the surface of a powder (e.g. and extender pigment such as talc or a while pigment such as titanium oxide) with a silicone compound represented by the formula (Rf is a monovalent polyfluorohydrocarbon group; (m) and (n) are each 1-5; (k) is 0-100; R1 is H, an alkyl or an aryl; R2 and R3 are each a 1-10C alkyl or an aryl; R4 is a monovalent hydrolyzable group; R5 and R6 are each a 1-10C alkyl, an aryl or the like; Me is methyl). A wet or a dry method at a treating temperature of room temperature to 200 deg.C is preferably adopted as the method for treating the powder. The compound represented by the formula is used in an amount of preferably 0.1-100 pts.wt. based on 100 pts.wt. of the powder in the surface treatment. Thereby, the powder for makeup excellent in water and oil repellencies is provided.
NEW MATERIAL:A virus multiplication suppressing factor having the following physical and chemical properties. Molecular weight: about 40Kd (gel filtration method). Color reaction: positive in Lowry reaction and negative in anthrone reaction. Enzyme stability: deactivated by trypsin treatment. Thermostability: deactivated by treatment at 56 deg.C for 30 minutes. pH stability: stable at pH 3. Isoelectric point: about 5.7. USE:A preventive and remedy for viral diseases. PREPARATION:Cells derived from mouse placenta and a virus multiplication suppressing factor is collected from the culture mixture. The cells are cultured using FERM P-1,0689 at 37 deg.C for 3 days until the cells become a crowded state and, after exchange of the medium, cultured for 4 days.
One of the challenging goals of root canal therapy is to relieve the pain associated with irreversible pulp inflammation. Pain control especially in the early stages of treatment, is critical and can enhance the confidence of both the patient and the dentist. Irreversible pulpitis pain is sometimes difficult to be managed through the use of local anesthetics solely. Inadequate pain control during treatment may contribute to the development of peripheral and central sensitization leading to greater pain during recovery. Various mechanisms have been proposed to explain the failure of local anesthetics including anatomic variations such as; cross innervations and accessory innervations, tachyphylaxis of anesthetic solutions, and activation of nociceptors including tetrodotoxin (TTX).Strategies to control intra-operative endodontic pain include preoperative administration of analgesics, supplemental infiltrations, the use of different local anesthetic solutions, intra-osseous and periodontal injections, a repeat inferior alveolar nerve block. Prescribing drugs prior to treatment may enhance the patient's attitude and reduce the apprehension during endodontic therapy. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common category of medications recommended for pain relief. They act by inhibition of prostaglandin synthesis by inhibition of cyclooxygenase pathway. Although, pulpectomy and removal of the inflamed pulpal tissues eliminates endodontic pain, post-operative pain and discomfort are common side effects. Many patients may still experience mild to extreme pain even after therapy. Diclofenac has shown a substantial reduction of post-endodontic pain when administered preoperatively in a single oral dose since it holds anti-inflammatory, antipyretic and analgesic effects. It acts primarily by inhibition of COX 1 and COX 2, thus inhibiting the prostaglandin synthesis. COX 1 is expressed throughout the body and has a role in protection of stomach mucosa, kidney function and platelet action. Numerous studies have clearly documented that the risk of upper gastrointestinal complications increases with increasing doses as well as increasing frequency of use. Additionally, when taken through oral route, only 50% of the absorbed dose of Diclofenac becomes available systematically, due to its first pass metabolism. Trans-mucosal drug delivery offers distinct advantages over oral administration such as avoiding hepatic first-pass metabolism, less dosing frequency, improved patient compliance, reduction in fluctuation in steady-state levels. In addition, there is a reduced intensity of local or systemic side effects, increased safety margin and maximum utilization of drug and reduction in the total amount of drug administered while achieving target delivery in odontogenic region.
BACKGROUND: This study analyzed the burden of chronic obstructive pulmonary disease (COPD) in China, the United States, and India from 1990 to 2019 and projected the trends for the next decade.
METHODS: This study utilized the GBD 2019 to compare the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life years (DALYs) rate, and the proportion attributed to different risk factors in China, the United States, and India. Joinpoint models and autoregressive integrated moving average (ARIMA) models were employed to capture the changing trends in disease burden and forecast outcomes.
RESULTS: From 1990 to 2019, China's age-standardized COPD incidence and mortality rates decreased by 29% and 70%, respectively. In the same period, India's rates decreased by 8% and 33%, while the United States saw an increase of 9% in COPD incidence and a 22% rise in mortality rates. Smoking and ambient particulate matter pollution are the two most significant risk factors for COPD, while household air pollution from solid fuels and low temperatures are the least impactful factors in the United States and India, respectively. The proportion of risk from household air pollution from solid fuels is higher in India than in China and the United States. Predictions for 2030 suggest that the age-standardized DALY rates, ASIR, and ASMR in the United States and India are expected to remain stable or decrease, while China's age-standardized incidence rate is projected to rise.
CONCLUSION: Over the past three decades, the incidence of COPD has been decreasing in China and India, while showing a slight increase in the United States. Smoking and ambient particulate matter pollution are the primary risk factors for men and women, respectively. The risk of household air pollution from solid fuels in India needs attention.