anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In recent years, with the improvement of the material living standards of the investigators residents and the change of working lifestyle, the prevalence and mortality of coronary heart disease (CHD) in urban and rural residents in China have increased year by year. According to statistics, the number of patients with coronary heart disease in China is currently 11 million. Coronary heart disease has become a major health problem in China. At present, it is found that inflammatory reaction and oxidative stress factors are involved in the occurrence and development of coronary heart disease, and their indicators such as heart rate variability are related to the prognosis of coronary heart disease. Fastigial nucleus stimulation (FNS) has been widely used in the treatment of various diseases such as cerebrovascular disease, migraine, and eye diseases. The study found that FNS can reduce inflammatory cytokines and oxidative stress factors in ischemic myocardium and improve heart rate variability in rats with myocardial infarction. The aim of this study was to investigate whether FNS can improve the aforementioned indicators and clinical outcomes in patients with coronary heart disease.
spectral domain optical coherence tomography, SD-OCT, (Heidelberg Engineering, Heidelberg, Germany) is a widely used commercial device in ophthalmology field. For a long time, retinal nerve fiber layer (RNFL) thickness was measured with OCT to detect and follow up glaucoma patients. Bruch's membrane opening - minimum rim width (BMO-MRW) is relatively new parameter which measures the minimum distance between Bruch's membrane opening to internal limiting membrane (ILM). BMO-MRW,a new parameter, is known to have better diagnostic performance than RNFL thickness and recently, many researches has been performed on this new parameter. SD-OCT can measure RNFL thickness and BMO-MRW at the same time. The test procedure is not different from RNFL thickness measurement but only software implemented in OCT device calculates BMO-MRW as well as RNFL thickness. The investigators are going to compare these two parameters and find out the relationship between two parameters.
A virtual health system (101) is provided that creates a digital platform to connect patients to healthcare providers (110). Healthcare providers create profiles (211) that describe their healthcare specialty and provide scheduling information (320) that indicates their availability along with preferences such as appointment or meeting length (330), minimum break between appointment (340), and price. Patients (105) create profiles (206) that includes demographic information as well as medical records. The patients may use the system to search for available healthcare providers using a variety of criteria, and to schedule virtual health services (116) such as video chats. The system facilitates payment (226; 450) for the healthcare services, and records any notes, assignments, or prescriptions generated by the healthcare provider during the services (460). In the event that a patient would like to engage a different healthcare provider associated with the system, the system only allows access to the patient records after receiving permission from the patient (500).
Provided is a praziquantel pill suitable for distribution by unmanned aerial vehicles, comprising: praziquantel, and a bait layer and a waterproof layer that sequentially encapsulate praziquantel from inside to outside. The waterproof layer is further provided with air vents. The bait layer comprises nutritional ingredients, a phagostimulant, and a preservative. The present invention can be used for expelling parasites, including Echinococci, in intestinal infections of canine animals and feline animals in villages and wild environments, and features improved edibility, water resistance and usability of parasiticides and prolonged service life before intake in wild environments. The present invention is not only useful for distribution in wild environments, but also helpful for distribution and use in household environments. In household use, the waterproof layer can be removed.
BACKGROUND: Regional anesthesia is an alternative to opioids for pain in patients undergoing liver transplantation. Quadratus lumborum blocks may provide appropriate dermatomal coverage with an excellent safety profile.
METHODS: Data were collected retrospectively on adult patients who underwent liver transplant at an academic medical center from 2019 to 2022 (n = 207). The primary outcome was opioid administration during the 48 h after transplant.
RESULTS: Patient demographics did not differ between groups. No association was found between patients who received a block and postoperative opioid administration (p = 0.848). However, among patients extubated in the operating room, patients who received a block reported, on average, a 0.9-unit lower pain score than patients who received no block (p = 0.041). Patients who received a block were also more likely to be extubated in the operating room (87.8% block vs. 44.4% no block; p < 0.001).
CONCLUSION: Patients who underwent liver transplantation had similar postoperative opioid use whether or not they received a quadratus lumborum block. Yet, when evaluating additional factors, such as extubation, pain scores were lower in patients who received a quadratus lumborum block. This important finding supports the idea that quadratus lumborum blocks may be a safe and valuable technique for controlling postoperative pain in adult patients who undergo liver transplantation.
The invention discloses an application of bergapten in treating depression, belonging to the technical field of medicines. The invention firstly provides a natural medicine bergapten which can prevent and treat depression by adjusting inflammatory reaction and obviously improve depression symptoms. Bergapten can obviously reduce the immobility time in a Lipopolysaccharide (LPS) -induced antidepressant mouse tail suspension test and a forced swimming test; the percentage of sugar water preference is increased and the autonomic activity is enhanced. The action mechanism is related to the regulation of nerve inflammation reaction mediated by the activation of the microglia of depressed mice. The invention provides a new way for improving the existing treatment method of depression. The scheme of the invention can realize the new application of the old medicine and can greatly shorten the time from the discovery of the medicine to the clinical conversion.
The invention provides gene engineering antibacterial peptide and a preparation method and application thereof, which can solve the problems of complicated structure, low antibacterial capacity and not wide antibacterial spectrum in the prior art. The antibacterial peptide has the amino acid sequence of KWKLFKKIAGPKFLHSKKKFN. According to antibacterial characteristics of cecropinA and magainins, a novel antibacterial peptide amino acid sequence is independently designed. On the basis, a preferred codon of pichia pastoris is selected, a novel antibacterial peptide gene is artificially synthesized and is cloned in the pichia pastoris for expression, a novel antibacterial peptide recombinant yeast strain, the fermentation scale is amplified to the fermentation tank level, and the high-density fermentation and high-efficiency expression of the antibacterial peptide product are realized. Fermentation liquor is further purified and prepared into powder, liquid and other preparations of the antibacterial peptide. The preparations of the gene engineering antibacterial peptide can serve as a livestock feed additive or are used for controlling livestock diseases.
Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morphological alterations in sensory and motor systems during late stages of diabetes remain largely unexplored. In the current work, we examined the influence of diabetes on sensory and motor function as well as morphological changes in late stages of diabetes. The obese diabetic Leprdb/db mice (db/db) were used for behavioral assessments and subsequent morphological examinations. The db/db mice exhibited severe sensory and motor behavioral defects at the age of 32 weeks, including significantly higher mechanical withdrawal threshold and thermal latency of hindpaws compared with age-matched nondiabetic control animals. The impaired response to noxious stimuli was mainly associated with the remarkable loss of epidermal sensory fibers, particularly CGRP-positive nociceptive fibers. Unexpectedly, the area of CGRP-positive terminals in the spinal dorsal horn was dramatically increased in diabetic mice, which was presumably associated with microglial activation. In addition, the db/db mice showed significantly more foot slips and took longer time during the beam-walking examination compared with controls. Meanwhile, the running duration in the rotarod test was markedly reduced in db/db mice. The observed sensorimotor deficits and motor dysfunction were largely attributed to abnormal sensory feedback and muscle atrophy as well as attenuated neuromuscular transmission in aged diabetic mice. Morphological analysis of neuromuscular junctions (NMJs) demonstrated partial denervation of NMJs and obvious fragmentation of acetylcholine receptors (AChRs). Intrafusal muscle atrophy and abnormal muscle spindle innervation were also detected in db/db mice. Additionally, the number of VGLUT1-positive excitatory boutons on motor neurons was profoundly increased in aged diabetic mice as compared to controls. Nevertheless, inhibitory synaptic inputs onto motor neurons were similar between the two groups. This excitation-inhibition imbalance in synaptic transmission might be implicated in the disturbed locomotion. Collectively, these results suggest that severe sensory and motor deficits are present in late stages of diabetes. This study contributes to our understanding of mechanisms underlying neurological dysfunction during diabetes progression and helps to identify novel therapeutic interventions for patients with diabetic neuropathy.
Serrated polyposis syndrome (SPS) presents with multiple sessile serrated lesions (SSL) in the large intestine and confers increased colorectal cancer (CRC) risk. However, the etiology of SPS is not known. SSL-derived organoids have not been previously studied but may help provide insights into SPS pathogenesis and identify novel biomarkers and chemopreventive strategies. This study examined effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of SPS patients. We also compared with organoids representing the hereditary gastrointestinal syndromes, Familial Adenomatous Polyposis (FAP) and Lynch syndrome (LS). Eighteen total organoid colon cultures were generated from uninvolved colon and polyps in SPS, FAP, LS, and non-syndromic screening colonoscopy patients. BRAF and KRAS mutation status was determined for each culture. Erlotinib (EGFR inhibitor) and sulindac (COX inhibitor) were applied individually and in combination. A 44-target gene custom mRNA panel (including WNT and COX pathway genes) and a 798-gene microRNA gene panel were used to quantitate organoid RNA expression by NanoString analysis. Erlotinib treatment significantly decreased levels of mRNAs associated with WNT and MAPK kinase signaling in organoids from uninvolved colon from all four patient categories and from all SSL and adenomatous polyps. Sulindac did not change the mRNA profile in any culture. Our findings suggest that EGFR inhibitors may contribute to the chemopreventive treatment of SSLs. These findings may also facilitate clinical trial design using these agents in SPS patients. Differentially expressed genes identified in our study (MYC, FOSL1, EGR1, IL33, LGR5 and FOXQ1) may be used to identify other new molecular targets for chemoprevention of SSLs.
QG-A is a smart phone application targeting alcohol use disorder. QG-A includes standardized cognitive-behavioral therapy in the form of videos, in-app text, audio recordings, and quizzes. The application provides users with information on how to reduce or abstain from alcohol use. Once successfully enrolled in QG-A, a medical provider will evaluate each QG-A participant for appropriateness for pharmacotherapy during an initial 60-minute assessment to confirm an alcohol use disorder diagnosis and collect relevant medical and psychiatric history of the patient. The medical provider will subsequently prescribe oral naltrexone via the QG-A telemedicine platform. A study counselor will provide manualized CBT-based support to QG-A participants via the video telemedicine function, as well as asynchronously via the in-app chat function.
After receiving one session of Brief Advice (BA) and two sessions of Motivational Interviewing (MI) or one session of BA over the first 8 weeks of the study, participants will be assessed at week 8 for response to this treatment. Those who are deemed non-responders will be randomly assigned to receive Behavioral Self-Control Training (BSCT) or more MI if they were randomized to MI at week 4 or five sessions of combined MI and BSCT or one more session of MI if they were randomized to BA at week 4. In this arm, participants will receive four sessions of BSCT if they received MI at the previous randomization or five sessions of combined MI and BSCT if they received BA at the previous randomization.
PURPOSE: The systemic and local inflammatory response in patients after surgical operation is closely related to the quality of the wound healing. Low-quality wound healing and defects in the suture technique lead to the occurrence of incisional hernia (IH). However, the causal relationship between human circulating inflammatory cytokines, immune cell traits, and the risk of IH remains unclear.
METHODS: We used summary data from genome-wide association studies to assess the causal relationship between 91 types of circulating inflammatory factors, 731 types of circulating immune cell traits, and the risk of IH. The outcome dataset was obtained from FinnGen, including 6,336 patients with IH and 232,612 controls. We performed Mendelian Randomization (MR) analysis to identify their causal relationship and immune cell phenotypes upstream of inflammatory factors. Inverse variance weighting is considered to be the main analysis method.
RESULTS: Among the identified cytokines, TNF-related activation-induced cytokine levels were associated with a lower risk of IH (OR: 0.89; 95% CI: 0.82-0.96; P = 0.003). In contrast, interleukin-5 levels were associated with an increased risk of IH (OR: 1.18; 95% CI: 1.06-1.31; P = 0.003). Additionally, a significant causal relationship was found between four immune cell traits and the risk of IH (P < 0.01). Through two-step MR analysis, we determined that interleukin-5 levels mediate the causal relationship between the relative count of CD25hi % CD4 + in Treg cells and the higher risk of IH.
CONCLUSION: This study found a causal relationship between specific inflammatory cytokines, immune cell traits, and risk of IH. These results can help surgeons predict the risk of IH and take preventive measures.
FIELD: virusology. SUBSTANCE: the object of the invention can be achieved by passing the strain isolated from the organs of the dog died of adenovirosis through the organism of intact puppies to the primary trypsinized cell culture of puppies' kidneys. The strain thus obtained has an antigenic kinship with the well-known adenovirus strains and is accumulated to a titer of 10 5,0-5,5  TЦД 50 /ml in the primary cell culture of puppies' kidneys. During production of a vaccine, the inactivant is formalin and the adjuvant is aluminium hydroxide. The resulting vaccine has high immunogenicity. EFFECT: a type 2 dogs' adenovirus strain having wide antigenic spectrum, greater antigenic and biological activity in cell systems and stable virulence for dogs.
PURPOSE: To obtain a composition for oral cavity which is composed of a water- insoluble noncationic antimicrobial, a specific antimicrobial increasing agent and a vehicle, possesses enhanced delivery and retention of antimicrobials and is useful for lowering generation of gingivitis. CONSTITUTION: This composition comprises (A) a substantially water-insoluble noncationic antimicrobial, e.g. halogenized diphenyl ether (particularly triclosan) and halogenized salicylanilide, (B) an antimicrobial increasing agent for enhancing delivery of the antimicrobial to oral cavity surface and its retention there, for example, a polymer having delivery-increasing groups (e.g. oxygen, phosphonic acid and carboxylic acid) and/or organic retentive increasing groups [e.g. O(X)n -R (X is 0, N and S; R is an alkyl, an aryl and an acyl; (n) is O and 1)], e.g. a poly (β-styrene-phosphonic acid, and (C) a vehicle useful for dissolving the antimicrobial in an amount showing dental calculus-resistant effect into saliva. The composition contains the component B in the range of 0.005-4wt.%.
In order to meet these needs, the present invention is directed to therapeutic and diagnostic agents capable of forming covalent bonds to blood and pulmonary fluid proteins or other components ex vivo or in vivo. The therapeutic agents of this invention have a long duration of action for the management of disease. The invention relates to ex vivo and in vivo bioconjugation of therapeutic agents to protein (e.g. albumin), as well as an intrapulmonary in vivo bioconjugation of therapeutic agents to endogenous pulmonary fluid proteins or other components to dramatically increase the half life of the therapeutic agents and avoid the need for parenteral administration. This invention is further directed to the use of reactive chemistries including: N-hydroxy sulfosuccinimide, maleimide-benzoyl-succinimide, gamma-maleimido-butyryloxy succinimide ester, maleimidopropionic acid, isocyanate, thiolester, thionocarboxylic acid ester, imino ester, and carbodiimide anhydride. Maleimidopropionic acid is the preferred reactive chemistry, but the invention also contemplates the selection of the above and like reactive chemistries as an electrophilic moeity for bioconjugations with albumin or other proteins. Modified therapeutic agents mentioned are the anti-histamine drug loratidine or cetirizine, a hypothyroid drug, the anti-angina drug tirofiban, the anti-hypertensive drug enalapril, the anti-arrhytmic drug capobenic acid, the antidepressant drug fluoxetine, the bronchodilation drug the obromineacetamine, the antiinflammatory drug loxoprofen, the anti-thyroid deficiency drug thyroxin, and 4-anilino-1-(2-phenethyl)piperidine.
PURPOSE:To provide a powdery pack having improved activity such as the tightening of the skin, adsorption and removal of the dirt from the skin, smoothening of the skin, etc., and containing powder of vegetables produced by drying the juice or extract liquid of vegetables, an organic or inorganic diluent, and if necessary, plaster of Paris. CONSTITUTION:The objective powdery pack contains (A) powder obtained by drying the juice or extract liquid of vegetables (e.g. barley, aloe, Japanese green gentian, creeping saxifrage, white-bird's-eye, licorice, peony, etc.), (B) an organic diluent (e.g. lactose, starch, etc.) or inorganic diluent (e.g. titanium white, kaolin, zinc white, diatomaceous earth, etc.), and if necessary (C) plaster of Paris. When 100-300pts.wt. of plaster of Paris is added to 3-10pts.wt. of the powdery pack composed of the component A and the component B (0.1-10 times weight of the component A), the plaster is hydrated with the water in the beauty wash used together with the powdery pack to cause the heat generation, and the warming effect to the skin and the massaging effect caused by the precipitation of crystals are developed thereby.
Despite the wide range of contraceptive technologies currently available the rate of unintended pregnancies in the U.S. remains high. In particular, adolescents, unmarried, low income, and minority women are amongst the highest risk populations for unintended pregnancy . Improving contraceptive use is critical for addressing this problem. Many programs have been developed and implemented to reduce sexual risk-taking behavior, one of the precursors to unintended pregnancies. Unfortunately, most of them have met with mixed results. Gaining insight into contraceptive practice and sexual behavior in this population is the first step towards improving contraceptive use. Many other disciplines have successfully used the internet for purposes of research (ie. asthma management, smoking cessation,etc), but this use of the internet has not been explored with adolescent women.

The study we are proposing is a randomized control trial to evaluate the use of internet technology in communicating with adolescent women about contraceptive practice. This study is a sub-study within an ongoing 12-month, longitudinal observational study of a cohort of "high-risk" women and their contraceptive practices and sexual behavior. Our hypothesis is that women who have access to the internet are more likely to complete follow-up surveys while enrolled in this longitudinal study, thus enabling us to obtain a greater understanding about contraceptive practice within this population via the internet. Furthermore, if internet proves to be a more effective means of communicating with adolescents because of the potential convenience and privacy of the method we may increase our impact on contraceptive use by embracing internet technology in the future.

Participants with internet access within the larger study will be identified and entered into a sub-study and randomized to either in clinic follow-up surveys or remote access completion of surveys via email over the internet. All participants will undergo the same screening, consent, and entry criteria for the study.
PROBLEM TO BE SOLVED: To obtain a coloring shampoo composition well foaming on its employment, sufficient in color strength and free from skin irritation by including a specific N-alkylamidoalkanol sulfuric acid ester salt. SOLUTION: This coloring shampoo composition contains at least one kind of a direct hair dye and an N-alkylamidoalkanol sulfuric acid ester salt of the formula [R<1> is a 6-22C alkyl, etc.; R<2> is a 1-22C alkyl, etc.; R<3> is a 1-5C alkylene; R<4> O is a 2-3C oxyalkylene; (n) is 0-20; M is H, an alkali metal, a 2-9C alkanol ammonium, etc.]. The compound of formula is preferably contained in an amount of 0.1-50wt.% based on the whole composition, and the composition may further contain 0-25wt.% of an anionic surfactant, 1-15wt.% of a nonionic surfactant and 0.1-5wt.% of an amphoteric surfactant except the compound of the formula. A cationic polymer as a conditioning additive is preferably further formulated in an amount of 0.1-2wt.%.
A N,N-dimethyl imidodicarbonimidic diamide nicotinate is provided to improve manufacturing with low toxicity and prevent and treat diabetes and complication of diabetes. A metformin nicotinic acid salt is denoted by the chemical formula 1. In the chemical formula 1, n is 1 or 2. The metformin nicotinic acid salt is anhydrous or hydrous state. A method for manufacturing the metformin nicotinic acid salt comprises: a step of reacting 1-4 mole equivalent of inorganic base in sodium hydroxide or potassium hydroxide in water or organic solvent to produce metformin free base of the chemical formula 3; and a step of removing inorganic salt in the compound of the chemical formula 3 and reacting with 1-4 mole equivalent of nicotinic acid of the chemical formula 4. The organic solvent is methanole, ethanol, isopropanol, acetone, or acetonitrile. A pharmaceutical composition comprises the metformin nicotinic acid salt of the chemical formula 1 as an active ingredient.
Activator The researcher made wax impressions of the study's patients for both the activator and treatment monitoring. The researcher instructed the patients to use the activator device for 12-14 hours daily, with a minimum requirement of 12 hours. Precise ablation of the activator created plastic surfaces that guided the process of tooth eruption.