anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In several clinical studies, zonisamide was associated with a statistically significant 8% mean increase from baseline of serum creatinine and blood urea nitrogen (BUN) compared to essentially no change in the placebo patients. The increase appeared to persist over time but was not progressive; this has been interpreted as an effect on glomerular filtration rate (GFR). There were no episodes of unexplained acute renal failure in clinical development in the US, Europe, or Japan. The decrease in GFR appeared within the first 4 weeks of treatment. In a 30-day study, the GFR returned to baseline within 2 to 3 weeks of drug discontinuation. There is no information about reversibility, after drug discontinuation, of the effects on GFR after long-term use. Zonisamide should be discontinued in patients who develop acute renal failure or a clinically significant sustained increase in the creatinine/BUN concentration. Zonisamide should not be used in patients with renal failure (estimated GFR < 50 mL/min) as there has been insufficient experience concerning drug dosing and toxicity.
The present invention relates to a pharmaceutical composition for preventing and treating hepatitis C and, more specifically, to a composition containing an inhibitor suppressing the expression or activation of Abelson interactor 1 (Abi1). As a result of identifying cell proteins interacting with a HCV NS5A protein by using a protein microarray technique by inventors in the present invention, about 90 cell proteins were identified to interact with the HCV NS5A protein. Abi1 was selected from the partners of the NS5A. The binding between the HCV NS5A and Abi1 was confirmed by using an in vitro pull-down assay and a common precipitation analysis. Abi1 is essential for replication of HCV. In addition, EGF-induced Erk and Efr1 activation was inhibited by the NS5A, and the inhibitory effect was mediated by the Abi1 protein. Knockdown of the Abi1 expression impaired the replication of HCV, while overexpression of the Abi1 increased proliferation of HCV. In summary, these results support that HCV forces the Abi1 in host cells to modulate a MEK/ERK signaling pathway for proliferation. Therefore, a substance inhibiting the activation or expression of the Abi1 is useful as a prophylactic agent or a therapeutic agent for hepatitis C by inhibiting the proliferation of HCV.
After signing the voluntary consent form, the participants will be filled in the socio-demographic data collection form, the hypoglycemic attudes and behavior scale, the risk perception scale. A total of 4 group nurse coaching meetings will be held with individuals with type 1 diabetes, one to one over 7 days, under the framework of Theory of Integrative Nurse Coaching. Each of these interviews will last an average of 40-60 minutes. Interviews will be held online through the Zoom® webconferencing program at times scheduled jointly with the client. After the coaching meetings are over, the scales will be filled again and the HbA1c level will be requested from the blood results ordered at the doctor's request. In the coaching interviews, the materials specific to the coaching training received by the researchers (techniques such as the wheel of life, imagination, sabotage work, strong questions, Cartesian questions, SWOT analysis) will be used.
In this arm, participants will be given access to the course material 8 weeks following confirmation of their eligibility. During, the 8-week waiting period they will be asked to complete questionnaires at 4 weeks and 8 weeks. At 8 weeks they will be given access to the course material and will be asked to complete the same questionnaires 4- and 8-weeks following completion of the course material.
We describe a case of bowel perforation secondary to a recurrence of primary fallopian tube carcinoma treated more than a decade ago. A woman in her 70s presented to a rural centre with an acute abdomen. An abdominal CT showed a perforated ileum secondary to a pelvic mass. Emergency laparotomy identified the pelvic mass that was adherent to the side wall and invading the ileum at the site of perforation. Its adherence to the external iliac vessels posed a challenge to achieve en-bloc resection; therefore, a defunctioning loop ileostomy was created. Final histopathology and immunopathology were consistent with the recurrence of her primary fallopian tube carcinoma. The patient was further discussed in a multidisciplinary team meeting at a tertiary referral hospital. This case highlighted the importance of having a high index of suspicion for cancer recurrence, the utility of rapid source control laparotomy and multidisciplinary team patient management.
BACKGROUND: Since cardiovascular disease (CVD) stands as the primary cause of death in those with diabetes, and given the substantial influence of obesity as a common risk factor for both diabetes and atherosclerotic conditions, this investigation sought to find the relationship between anthropometric indicators and CVD risk within these populations.
METHODS: Our study examined 36,329 adults, including those with diagnosed diabetes, pre-diabetes, and without diabetes from National Health and Nutrition Examination Survey (NHANES) data spanning 1999 to 2018. Various anthropometric indicators such as body mass index (BMI), waist circumference, weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), weight, and height were assessed. Baseline characteristics were compared among the three groups after weighting. Participants were then grouped based on anthropometric indicators, and logistic regression models were used to analyze the association between these indicators and CVD risk in the total diabetes group (including diabetic and pre-diabetic individuals). Threshold effect analysis was conducted to explore nonlinear relationships, and mediation analyses assessed whether serum parameters influenced these relationships.
RESULTS: This cross-sectional study involved 36,329 participants, weighted to a count of approximately 160.9 million, including over 45.9 million pre-diabetic individuals and around 16.6 million diabetic individuals. Baseline analysis showed significant associations between all six anthropometric indicators and CVD risk across patients with different diabetes statuses. Weighted restricted cubic spline (RCS) curve analysis highlighted increased CVD risk among the total diabetes group for each anthropometric indicator compared to the non-diabetic group. Anthropometric indicators were then divided into quartiles, and after adjusting for confounders, Model 3 revealed that the highest BMI group had a heightened risk of CVD compared to the lowest BMI group. Similar trends were observed in the WWI and WHtR subgroups. Threshold effect analysis of anthropometric indicators unveiled nonlinear associations between waist circumference, height, WWI and CVD risk. Mediation analysis suggested that lipid parameters, especially HDL, significantly mediated these relationships.
CONCLUSION: In individuals with diabetes and pre-diabetes, BMI, weight, and WHtR displayed a consistent, linear increase correlation with CVD risk. Conversely, the link between waist circumference, height, and WWI and CVD risk showcased a more complex, nonlinear pattern. Moreover, HDL level emerged as notable mediator in the association between anthropometric indicators and the risk of CVD.
PROBLEM TO BE SOLVED: To obtain a transcutaneous absorption plaster keeping the absorbency and safety of drug and having excellent light stability by applying a tacky adhesive layer containing a drug to one surface of a substrate composed of resin film scrap containing ultraviolet absorber. SOLUTION: This transcutaneous absorption plaster is produced by applying a tacky adhesive layer containing a drug to one surface of a substrate. The substrate is composed of at least two layers, at least one layer is a resin film containing an ultraviolet absorber and the other layer is a conventional substrate for plaster. The tacky adhesive is an acrylic adhesive, rubber-based adhesive, etc., capable of dissolving the drug and having pressure-sensitive adhesiveness to enable the adhesion to the skin over a long period at room temperature. The transcutaneous absorbefacient is an unsaturated fatty acid and its ester, a compound having amino group, a compound having amide bond, etc. The deterioration of the drug with light can be suppressed and the plaster is free from discoloration and has excellent stability and releasability of the drug.
Barely epirubicin was instilled after TURBT. Epirubicin was immediately instilled in 24h after TURBT. Instillation was conducted regularly for a year: once in a week for 8 times, once in two weeks for 8 times, once in a month for 6 times.
The invention discloses a Chinese patent medicine for curing apoplexy and hemiplegia sequela by external administration, and comprises a Chinese patent medicine patch, an extending muscle material matched to be used and point stimulating liquid. The original medicine of the Chinese patent medicine patch consists of 1 to 10 shares of pangolin scales, 1 to 10 shares of processed radix aconiti, 1 to 10 shares of clam meal, 0.5 to 10 shares of shallot juice liquid, 0.1 to 5 shares of hard drinks and 0.03 to 0.1 share of muskiness. The original medicine of the extending muscle material is formed by 20 to 40 shares of garden balsam stem, 20 to 40 shares of safflower and 20 to 40 shares of common clubmoss herb. The point stimulating liquid is formed by mixing the shallot juice liquid, the hard drinks and the muskiness. The group of medicines can be matched for application, with a remarkable effect for curing sequela of apoplexy and hemiplegy, a complementary drug effect and a general efficiency of 95.1 percent through the indication of clinic tryout. The treatment method is simple, with no hospitalization for ordinary sufferers, safety and no side effect.
Asymptomatic control subjects with no deformity. All patients will undergo all 3 interventions: MRI, qCT, and motion analysis.
BACKGROUND: The human hand has constant contact with the environment, hence requires regular hand hygiene. Hand hygiene has gained recognition because of the COVID-19 pandemic and is a largely effective, affordable preventive measure against infectious diseases. This study used both national and sub-national analyses to evaluate the effect of COVID-19 handwashing guidelines on instances of diarrhea in Ghana.
METHODS: Data on diarrhea cases spanning February 2018 and March 2022 were retrieved from the District Health Information Management System (DHIMS 2) using a data extraction guide. The data were summarized using descriptive statistics. The difference in diarrhea cases between the pre-COVID-19 and COVID-19 periods was measured using a two-sample t-test across Ghana's 16 administrative areas. Causal Impact package in R statistical software was employed to determine the impact of the introduction of COVID-19 hand hygiene protocols on diarrheal disease.
RESULTS: A total of 5,645,533 diarrheal cases reported between February 2018 and March 2022 through the routine MIS (DHIMS2) were examined. Fifty-three percent of the cases occurred before the introduction of the hand hygiene protocol. Descriptive statistics indicated a statistically significant decrease in average diarrheal cases during the hand hygiene implementation era (13,463 cases reduction, p<0.001). Sub-national analyses revealed significant reductions in various regions: Greater Accra, Ashanti, Ahafo, Central, Eastern, Northern, Upper East, Upper West, and Volta (p<0.05). Causal impact analysis confirmed 11.0% nationwide reduction in diarrheal cases attributed to the COVID-19 hand hygiene protocols (p<0.001).
CONCLUSION: This study underscores the effectiveness of COVID-19 hand hygiene protocols in reducing diarrheal morbidity in Ghana, with varying regional impacts. These findings advocate for the sustenance of investments and commitments made at the COVID hand hygiene protocols, particularly in this era where the pandemic appears controlled.
The robot NAO, academic edition (Aldebaran Robotics) was used in this study. Some of its features include an on-board fully programmable computer CPU: x86 AMD Geode with 500 MHz, 256 MB SDRAM and 1 GB flash memory, WiFi (802.11g) and Ethernet, two cameras with up to 30 frames per second, two hands with self adaptive gripping abilities, force sensitive sensors on its arms and feet to perceive contact with objects, Light Emission Diodes in its eyes and body, four microphones to identify the source of sounds, and two loud speakers for communication where tone and voice pitch can be modified in real-time. It runs on a native Linux Operating system platform and can be programmed using a proprietary SDK called NaoQi, or in C, C++, Ruby and Urbi, which makes it compatible with other robot simulators such as Microsoft Robotics Developer Studio.
The invention provides a pharmaceutical composition for treating rhinitis. A preparation method of the pharmaceutical composition comprises the steps that Jiejiehonghua, watermelon pedicle, pseudosciaena crocea, centipeda minima, magnolia flower and cordate houttuynia are decocted with water for extraction and concentrated into paste, radix angelicae is ground into powder to be mixed with the extract paste. The pharmaceutical composition is safe in ingredient, becomes effective rapidly and has the excellent effect. The invention further provides the preparation method of the pharmaceutical composition for treating rhinitis. The method is easy and convenient to implement and good in repeatability. The invention further provides application of the pharmaceutical composition in treating rhinitis such as allergic rhinitis, hypertrophic rhinitis, simple rhinitis and nasosinusitis. The pharmaceutical composition is multifunctional and has the good treatment effect on various types of rhinitis caused by various etiological factors.
Sterile, injectable therapeutic compositions comprise an injectable liquid carrier containing microscopic, medicament-containing capsules produced by liquid-liquid phase separation.  Suitable encapsulating materials include gelable hydrophillic colloids e.g. gelatin, albumin, fibrinogen, casein, agar, sodium oleate, pectin and ichtlyocolla which may be used alone or together with other colloid materials of opposite charge e.g. gum acacia, sodium carboxymethylcellulose, sodium alginate and cellulose-, amylose- and starch acetate phthalates and "linear macromolecular synthetic polymers" i.e. materials whose structure comprises both lipophilic and hydrophilic units e.g. those derived from styrene, and an alkyl ring-substituted styrene or an ether- or ester-substituted ethylene and those derived from maleic, crotonic or acrylic acids or maleic acid or acrylic acid amides respectively.  Examples of such polymers are styrene-maleic acid and styrene-maleic acid copolymers, sulphonated polystyrenes, polymethacrylic acid and vinyl ether-maleic acid copolymer.  The particles to be encapsulated may be solid, liquid or emulsion particles having either hydrophilic or lipophilic surface characteristics and the encapsulation may be achieved by any suitable liquid/liquid phase separation process e.g. those disclosed in Specifications 751,600, 911,483, 929,402, 929,408 and 929,409. The capsules may be hardened by chemical or physical means e.g. irradiation and their components may be sterilized by conventional techniques e.g. by heat, disinfecting gases or irradiation and the encapsulation process may be carried out under aseptic conditions. Specific examples relate to medicaments comprising solutions of testosterone propionate and 6 - methyl - D 1 - hydrocortisone - 21 - acetate in cottonseed oil encapsulated in gelatin/acacia, and a cottonseed oil-in-water emulsion containing methyl salicylate in the aqueous phase and D 1-hydrocortisone acetate in the oil phase encapsulated in gelatin/styrenemaleic acid copolymer.
An adhesive bilayer transdermal dosage system capable of sustained release of a pharmaceutically active drug to the skin of a human patient having a first component layer which is a pharmaceutically active drug-containing essentially planar sheet of an at least partially cross-linked acrylic adhesive. The planar sheet is formed of a flexible self-supporting cross-linked acrylate of sufficient adhesivity, durability and strength whereby intimate diffusional contact with the skin of the patient is maintained for a period of at least about 24 hours without destruction of the physical integrity of the sheet. The sheet is capable of retaining, dispersed therein, sufficient pharmaceutically active drug to deliver to the skin a pharmaceutically effective amount of the drug over a 24-hour period without dissolution of the at least partially crosss-linked acrylic adhesive. The system also contains a second component layer intimately adhered to one side of the first component layer. The second component layer is resistant to the passage of the pharmaceutically active drug from the first component layer. Methods for making the first component layer and dosage system are also disclosed.
Therapeutic Lifestyle Changes (TLC) diet. Used in cohorts 1, 2 and 3.
Azelastine hydrochloride administered orally for 24 months was not carcinogenic in rats and mice at doses up to 30 mg/kg/day and 25 mg/kg/day, respectively. Based on a 30 µL drop size, these doses were approximately 25,000 and 21,000 times higher than the maximum recommended ocular human use level of 0.001 mg/kg/day for a 50 kg adult. 

Azelastine hydrochloride showed no genotoxic effects in the Ames test, DNA repair test, mouse lymphoma forward mutation assay, mouse micronucleus test, or chromosomal aberration test in rat bone marrow. Reproduction and fertility studies in rats showed no effects on male or female fertility at oral doses of up to 25,000 times the maximum recommended ocular human use level. At 68.6 mg/kg/day (57,000 times the maximum recommended ocular human use level), the duration of the estrous cycle was prolonged and copulatory activity and the number of pregnancies were decreased. The numbers of corpora lutea and implantations were decreased; however, the implantation ratio was not affected.
The invention relates to a medical pillow, which comprises a pillow inner and a pillowcase, wherein the pillowcase wraps outside the pillow inner. The medical pillow has the innovation points that the pillow inner is filled with the following components in parts by mass: 100-150 parts of ginseng flower, 100-150 parts of Chrysanthemum morifolium Ramat and 100-150 parts of wolfberry fruit. The ginseng flower, the Chrysanthemum morifolium Ramat and the wolfberry fruit are filled in the pillow inner in proportion, and respective effects of the ginseng flower, the Chrysanthemum morifolium Ramat and the wolfberry fruit can be slowly exerted during long sleep of people. The ginseng flower has effects of enriching yin and nourishing kidney and reinforcing vital energy; effects of enriching yin and nourishing kidney and reinforcing vital energy can be exerted after males drink the ginseng flower for a long time, and effects of regulating Qi and blood and moistening skin and blacking hairs can be exerted after females drink the ginseng flower. The ginseng flower has functions of cooling, improving eyesight, refreshing and tonifying kidney and removing pimples and whelk. The medical pillow is good in health-care effect and meets the requirements of heavy-pressure and high-pace living of contemporary people.
There is a chronic inflammation in PCOS patients, which is correlated with the pathogenesis of PCOS. IL-18 and IL-18BP are related with some inflammatory diseases, while less explored in PCOS. Whether IL-18BP could be a potential drug of PCOS remains unknown.IL-18 and testosterone levels were evaluated in serum of 10 non-PCOS control patients and 20 PCOS patients. Female C57/BL6 mice were gavaged with letrozole to induce PCOS mouse model and IL-18 level was evaluated in the serum of PCOS mouse model, and IL-18 is intraperitoneally injected in female mice, IL-18BP is intraperitoneally injected in the PCOS mice models. Then the body weights, estrous cycles, reproductive hormones and morphology of ovaries were analyzed. The level of ovarian chronic inflammation, fibrosis and endoplasmic reticulum (ER) stress are evaluated.IL-18 levels are increased in the serum of PCOS patients and PCOS mice models respectively. The serum DHEAS, iWAT weight and adipocyte size were increased in IL-18 group compared to the control group (P < 0.05). In the PCOS mouse model treated with IL-18BP, the body weight and serum LH/FSH ratio was decreased compared to the PCOS group (P < 0.05). The expression levels of inflammatory factors and fibrosis-related genes, the expression level of endoplasmic reticulum stress-related genes, and the ROS positive area of ovarian tissue was decreased (P < 0.05).IL-18 is involved in inducing PCOS phenotypes, while IL-18BP relieves PCOS phenotypes by alleviating ovarian chronic inflammation, fibrosis and ER stress in PCOS mice.
Concomitant use of isosorbide mononitrate with phosphodiesterase inhibitors in any form is contraindicated (see CONTRAINDICATIONS).

Concomitant use of isosorbide mononitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS).

The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.
OBJECTIVE: To estimate the epidemiological and clinical burden of Clostridioides difficile infections (CDIs) and recurrences (rCDIs) in England.
METHODS: This retrospective study included adult patients diagnosed with CDI (community or hospital settings) over 2015-2019 from Clinical Practice Research Datalink and Hospital Episode Statistics databases. Incidences of CDI and rCDI were determined annually. Time to subsequent rCDI was estimated by Kaplan-Meier method. Rates of complications were assessed within 12 months from index episode. Association of risk factors with complications was evaluated using a Cox regression model.
RESULTS: A total of 52,443 CDI episodes were recorded among 36,913 patients. Of these, 75% were aged ≥65 years, 59% were women; 73% were treated in community settings. CDI incidence remained stable (111 episodes per 100,000 patients in 2019). Around 21% of patients had ≥1 rCDI. Sepsis (12%) was the most common complication, followed by colectomy and ulcerative colitis. Age, gender, comorbidities, rCDI, preindex medical procedures, hospitalizations and consultations, and CDI treatment in hospital, were found to increase the risk of complication.
CONCLUSIONS: CDI remains a concern in England. The study highlights the importance of managing primary and rCDI episodes via effective and improved therapies to prevent fatal complications.
PMR will be adapted from Berstein, Borkoveck, and Hazlett- Stevens (2000). PMR will be conducted in six, 60-90 min individual weekly sessions with a study therapist. Muscle groups are tightened and then relaxed with the attention of the patient focused on the contrast between tension and relaxation. Through regular practice, the person becomes more aware of tension in the body and can induce relaxation as needed (Field, 2009). During the six sessions of training, patients will be encouraged to practice PMR and learn how to deliberately induce physical relaxation to reduce stress and mental tension. Sessions will move from relaxation of 16-muscle groups to 7 muscle groups, 4 muscle groups, and finally to relaxation by recall. Patients will be instructed to practice daily, if possible, but at least two or three times a week, and to integrate the practice into their daily life. They will be provided with audio recordings and homework reporting forms to assist their home PMR exercises.