anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The goal for the study was to collect a sample of one hundred adult patients admitted to an acute care medical surgical unit. A quasi-experimental study with a single-arm pre-/post-test design evaluated one-time use of inhaled aromatherapy on hospitalized adults on an acute care unit. Pre-test tools included a numeric pain rating scale, facial anxiety scale and Halpin's 0-5 nausea scale. Aromatherapy (Elequil aromatabs) was administered for 8 hours. Sleep, satisfaction, well-being, and concurrent medication use were assessed post-aromatherapy. Descriptive and inferential statistics were performed. These subjects had to be conscious, oriented, able to consent, and able to understand the purpose of the study. Exclusion criteria were otolaryngology free flap patients (as this was a study being conducted on an otolaryngology acute care unit and another study was occurring with this population), patients with known allergies to essential oils, those taking sleep medications, or who have an aroma/essential oil contraindication. The use of a pre and post survey was used to measure the effectiveness of aromatherapy on pain, anxiety, and nausea. A baseline assessment was made of these ailments via Qualtrix. Subjects chose the aromatherapy tab fragrance that best fit their chief complaint, which was placed on their gown. After eight hours, a post-application survey to assess pain, anxiety, nausea, sleep/relaxation, overall satisfaction, and overall wellbeing was administered via Qualtrix. A numeric pain scale from 0-10, a 0-5 Likert Anxiety scale and a 0-5 nausea scale were used to measure efficacy. Sleep, satisfaction, and wellbeing was assessed with yes/no. A chart review to determine any measurable benefits in the reduction of related medications while using aromatherapy was to be conducted once one hundred subjects were obtained. The period for this study was approximately fifteen months.
Women randomized to the treatment group will complete the baseline survey and receive the same brochure; however, they also will receive structured education regarding unintended pregnancies among women using opioids, potential complications associated with opioid, alcohol, and other drug use, and education on contraceptive use (with an emphasis on LARC). This structured education will be coupled with a brief, initial MI conversation. The interventionist will receive respective patients' MINI for opioids,37 contraceptive survey, and WHO-QOL-B from the research coordinator, and the answers to the survey forms will expedite the conversation around each woman's contraceptive desires.
Venous thromboembolism (VTE) is the third leading cause of cardiovascular death, with an increase in annual incidence with age. With the advent of direct oral anticoagulants, the management of deep vein thrombosis and pulmonary embolism has evolved in recent years and these treatments are widely prescribed. There are studies comparing the different anticoagulant treatments used in venous thrombosis, which show no inferiority of treatment (injectable or oral) compared to others. Drug delivery modalities have been shown to affect adherence, and thus treatment efficacy. It seems fundamental to focus on patients' drug preferences in VTE to ensure the best possible compliance. These preferences seem to depend on the personal history of each patient. In addition, no studies have been conducted on patient preferences for anticoagulant therapy for VTE: this is the goal of the "anticoagchoice" study.
The invention discloses a recombination yeast engineering bacteria expressing reticuloendotheliosis virus Gp90 protein, its construction method and application. The recombination yeast engineering bacterial strain is preserved in CGMCC with the preservation number CGMCC No. 5046. With large scale induction of the engineering bacterial strain, the expression of Gp90 protein is 373 mg/L. The SDS-PAGE and Western blot detections prove that expressed recombination protein has biological activity and antigenicity of reticuloendotheliosis virus natural protein. By preparing an antigen vaccine from the recombination protein to immunize SPF chickens, the results show that: the recombination antigen vaccine can effectively induce the organism to generate specific humoral immune response to prevent the SPF chickens from attack of anti-REV, and can effectively prevent the propagation of the virus in body.
Subjects eat a reference lunch (reference lunch) at 11:30 am, 4 h after a defined light breakfast. The meal contains 38 g fat and 885 kcal. The participants eat the cheese portion within 15 min and the remaining components of the meal are consumed within the following 15 min (total eating time=30 min).
OBJECTIVE: To study sociodemographic and clinical factors associated with the long-COVID-19 syndrome among women living in Latin American countries using undirected and directed methods.
METHOD: We studied 347 patients with COVID-19 (confirmed by polymerase chain reaction) living in nine Latin American countries between May 2021 and July 2022, including 70 premenopausal, 48 perimenopausal, and 229 postmenopausal women. We compared the sociodemographic and general health information of women with (n = 164) and without (n = 183) the long-COVID-19 syndrome. They also completed the Connor-Davidson Resilience Scale, the Fear of COVID-19 Scale, the Jenkins Sleep Scale, and the Menopause Rating Scale to define the minimum set of variables for adjustment. We designed a directed acyclic graph (DAG) to identify factors related to the long-COVID-19 syndrome. Data were submitted to categorical logistic regression analyses. Results are reported as means and standard deviations or β-coefficients and 95 % confidence intervals.
RESULTS: Women with long-COVID-19 syndrome had a poor lifestyle, severe menopause symptoms, hypertension, insomnia, depression, anxiety, chronic diseases/conditions, risk of hospitalization, sleep disturbance, and low menopause-related quality of life compared to women without the syndrome. The DAG identified the following long-COVID-19 covariates: age, obesity, anxiety, depression, cancer, lifestyle, smoking, and menstrual status. A multivariable logistic model with these covariates indicated that anxiety is the only factor to be significantly associated with long-COVID-19 syndrome, whereas other covariates were confounding factors. There was no significant influence of menopausal status on the long-COVID-19 syndrome.
CONCLUSION: Among factors selected by the DAG, only anxiety was significantly associated with the long-COVID-19. There was no significant influence of the menopause status on the long-COVID-19 syndrome in the studied population.
The present invention relates to medicine for treating facial palsy, and a preparing method thereof. The medicine is basically composed of musk, pangolin, scorpion, leech, bombyx batryticatus, giant typhonium tuber, climbing groundsel, frankincense, myrrh, isatis root, isatis leaf, cortex erythrinae, tuberculate speranskia herb, common fennel and red lead. The medicine is prepared by purification and decoction. The preparing method is easy to operate, the effective components of pure traditional Chinese medicine are extracted and externally used, and the medicine has no toxic or side effect and no damage for a human body. The human body has no pain in the process of treatment, the therapeutic effect is good, and the therapeutic period is short. An early patient can generally recover after applied for 3 to 4 times.
BACKGROUND: This study was conducted to investigate the clinical value of a navigation system based on deep learning and mixed reality for the treatment of kidney stones with percutaneous nephrolithotomy (PNL), and to improve its theoretical basis for the treatment of kidney stones.
METHODS: The data of 136 patients with kidney stones from October 2021 to December 2023 were retrospectively analyzed. All patients underwent PNL, and were categorized into a control group (Group 1) and a surgical navigation group (Group 2) according to puncture positioning method. Preoperative computed tomography (CT) was performed in both groups. In group 1, procedures were performed under standard ultrasound guidance. PNL was performed with navigation system fused with ultrasound to guide percutaneous puncture in group 2. The baseline information and procedural characteristics of both groups were compared.
RESULTS: PNL was successfully performed in both groups. No significant difference was found in the baseline date between the two groups. In group 2, real-time ultrasound images could be accurately matched with CT images with the aid of navigation system. The success rate of single puncture, puncture time, and decrease in hemoglobin were significantly improved in group 2 compared to group 1. (p < 0.05).
CONCLUSIONS: The application of navigation system based on deep learning and mixed reality in PNL for kidney stones allows for real-time intraoperative navigation, with acceptable accuracy and safety. Most importantly, this technique is easily mastered, particularly by novice surgeons in the field of PNL.
PURPOSE: A pharmaceutical composition containing tranexamic acid for preventing or treating Parkinson's disease is provided to prevent apoptosis of nerve cells in neuroblastoma(SH-SY5Y) and to suppress caspase 3 activation. CONSTITUTION: A pharmaceutical composition for preventing or treating Parkinson's disease or similar disease contains tranexamic acid of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound of chemical formula 1 forms an additive salt by reacting with pharmaceutically acceptable inorganic acid, organic acid, or base. The base is sodium, potassium, magnesium, or calcium. The inorganic acid is hydrochloric acid, or sulfuric acid. The organic acid is acetic acid or maleic acid. The composition is manufactured in the form of tablet, powder, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, or sterilized injection solution.
The medical community calls the movement from severe to mild disease and from mild to normal health, 'relieving symptoms', and the interventions that cause such movement, drugs, medications, or therapies. The alternative community calls the movement from normal health to superior health, 'boosting health' (or boosting the immune system, or improving your sex drive, or boosting any another well functioning physiological system), and the interventions that cause such movement, natural remedies, dietary supplements, complementary treatments, etc. In general, these interventions aim to achieve superior performance of a normal human body. Of course, boosting the body's normal performance improves many of its capabilities, such as higher resistance to diseases, faster recovery from fatigue, better mental concentration, etc. Each movement presents different objectives. Relieving symptoms represents the ability of an intervention to reduce the frequency, duration, and severity of a disease. In contrast, boosting health represents the ability of an intervention to increase the frequency, duration, and quality of a person's health. In the current study, the investigators would like to measure the changes in health-related complaints by analyzing charts of individuals, who are infected with latent virus, and who have used Gene-Eden-VIR/Novirin.
Group C (n=30) patients to whom caudal block will be applied will be placed in the lateral decubitus position and the linear ultrasound probe will be placed longitudinally in the sterilized area on the midline of the sacrum. A 2.5 cm 22 gauge needle will be inserted over the back skin of the sacral hiatus (located distal to the sacrum and formed by the two sacral cornua on its lateral edges) at a 90° position. The sacrococcygeal ligament will be crossed, the needle will be oriented approximately 25° and advanced approximately 2 to 3 mm to reach the sacral canal. After entering the sacral hiatus and confirming the location with negative aspiration method, 1 mL kg-1 0.25% bupivacaine will be injected by aspiration every 2 mL (test dose will be administered with 1 mL saline).
An insulin preparation having a protracted effect comprises the reaction product of insulin e.g. amorphous and crystalline insulin, and an isothiocyanate of aliphatic, aromatic, isocyclic, or heterocyclic compounds e.g. phenyl, ethyl, alkyl or octyl isothiocyanate.  The isothiocyanate may be stirred into an aqueous alkaline solution of the insulin e.g. in a phosphate or borate buffer solution, at room temperature, and the required product separated as a solid precipitate or aqueous layer. Reference is made to the production of insulin isocyanate.  The insulin may be prepared by the process of U.S.A. Specification 2,595,278.
Patients undergo magnetic MRI and surgical resection at baseline. Patients receive placebo PO on days 1 and 2 post-surgery, and then receive eflornithine PO and AMXT 1501 PO on days 3-5 post-surgery. Patients also undergo CT after surgery and collection of blood on study.
In the intervention arm, Linezolid is administered 600 mg as loading dose as an infusion lasting one hour (flow rate 300 ml/h), followed by continuous infusion of 1200 mg linezolid over 24 hours (flow rate 25 ml/h) which is immediately initiated. The continuous infusion is administered until the end of the treatment.
Fifty intermittent TBS sessions (1800 pulses per session, 50 minute inter-session interval ) were delivered as ten daily sessions over five consecutive days at 80% resting motor threshold (RMT). The MRI data set should be collected before the first cTBS session and after the last rTMS session. No actual magnetic stimulation was applied on the head of the volunteers. MRI dataset should be acquired before the first cTBS session and after the last cTBS session.
We performed a systematic review to explore existing evidence regarding the efficacy of lifestyle interventions for the management of systemic lupus erythematosus (SLE). The search was conducted on the 22nd of June 2021 for publications between 1st of January 2000 and the date of search. Additional articles within the aforementioned timeframe and until December 2023 were added by hand searching. Databases utilized were Medline, Embase, Web of Science, and Cinahl. Lifestyle interventions were defined as any intervention encompassing one or more of the following: physical exercise, diet and nutrition, mental health, harmful exposures, sleep, and social relations. The Joanna Briggs Institute critical appraisal tools were used for risk of bias assessment. The search yielded 11,274 unique records, we assessed the full text of 199 records, and finally included 102 studies. Overall, the quality of the evidence is limited, and there were multiple sources of heterogeneity. The two domains most extensively researched were mental health (40 records) and physical exercise (39 records). Psychological interventions had a positive effect on depressive symptoms, anxiety, and health-related quality of life (HRQoL), whereas physical exercise improved fatigue, depressive symptoms, aerobic capacity, and physical functioning. Studies on diet and nutrition (15 records) support that low fat intake and Mediterranean diet may be beneficial for reducing cardiovascular risk, but large interventional studies are lacking. Studies on harmful exposures (7 records) support photoprotection and use of sunscreen. While studies imply benefits regarding disease burden and drug efficacy in non-smokers and regarding HRQoL in normal-weight patients, more survey is needed on tobacco smoking and alcohol consumption, as well as weight control strategies. Studies on social relations (1 record) and sleep (no records) were sparse or non-existent. In conclusion, psychosocial interventions are viable for managing depressive symptoms, and exercise appears essential for reducing fatigue and improving aerobic capacity and physical function. Photoprotection should be recommended to all patients. Lifestyle interventions should be considered a complement, not a substitute, to pharmacotherapy.
In the metal plating industry, F-53B has been widely used for almost half a century as a replacement for perfluorooctane sulfonate. However, F-53B can reach the food chain and affect human health. Pregnant women have distinct physiological characteristics and may thus be more sensitive to the toxicity of F-53B. In the present study, F-53B was added to the drinking water of pregnant mice during gestation and lactation at doses of 0 mg/L (Ctrl), 0.57 mg/L (L-F), and 5.7 mg/L (H-F). The aim was to explore the potential effects of F-53B on glucolipid metabolism and pregnancy outcomes in dams. Results showed that F-53B induced disordered glucolipid metabolism, adverse pregnancy outcomes, hepatic inflammation, oxidative stress and substantially altered related biochemical parameters in maternal mice. Moreover, F-53B induced remarkable gut barrier damage and gut microbiota perturbation. Correlation analysis revealed that gut microbiota is associated with glucolipid metabolism disorders and hepatic inflammation. The fecal microbiota transplant experiment demonstrated that altered gut microbiota induced by F-53B caused metabolic disorders, adverse pregnancy outcomes, and gut barrier damage. These results suggested that maternal mice exposed to F-53B during gestation and lactation had an increased risk of developing metabolic disorders and adverse pregnancy outcomes and highlighted the crucial role of the gut microbiota in this process, offering novel insights into the risk of F-53B to health.
Participants will receive apalutamide 240 milligram (mg) (4\*60 mg tablets) and abiraterone acetate (AA) 1000 mg (4\*250 mg tablets) once daily on an empty stomach and 5 mg prednisone (P), AAP, twice daily, until disease progression, unacceptable toxicity or end of treatment, whichever occurs first. After unblinding participants will be offered further treatment as defined in the Open-Label Extension (OLE) or Long-Term Extension (LTE) phase (AAP + open label apalutamide or AAP alone).
In vitro infiltration of extracelluar antigens into the major histocompability complex class I-presentation pathway of cells, comprises determining specific parameters for antigen presenting cells, and transmitting the determined parameters, is new. In vitro infiltration of extracelluar antigens into the major histocompability complex class I-presentation pathway of cells, comprises determining specific parameters for antigen presenting cells, and transmitting the determined parameters. The determination of the parameters comprises contacting the cells with listeriolysin and marker substance (1 to 10 mg/ml), measuring the influx of the substance by fluorescence method, modifying the parameters and activating antigen specific CD8+T cells. The in vitro infiltration further comprises separation and/or concentration of the antigen-presenting cells by isolation by density gradient centrifugation and/or cell sorting, adjusting the cell concentration to 105-109 cells/ml, addition of the listeriolysin in concentrations of 1-5000 ng/ml and flow cytometric determination of the marker. The parameters comprise cell line or primary cell, in which the antigen is transferred, quality of the cells, cell concentration (105>/ml-109>/ml) used culture medium and/or buffer, presence or absence of serum components during the incubation, serum and/or cholesterol concentration, protein antigen, laboratory material, ambient temperature during the incubation, incubation period (1-45 minutes) of the cell line with the listeriolysin, size (540 kDa), charge and/or amino acid synthesis of the antigen, and type, concentration (1-250 ng/ml) and redox condition of the listeriolysin. The laboratory material is poly styrene-poly propylene, eppendorf, falcon tube, pipette tips, sample tube, microtiter plates and culture dishes. The cell line/primary cell is a primary human and murine cell, unseparated/separated cells such as peripheral blood mononuclear cells, monocyte/lymphocyte, mouse lymphoma cell line, mouse embryonic fibroblast cell line adherent, murine bone marrow cells in suspension and murine marrow macrophages. The listeriolysin (LLO) is culture protrusion, cleaned listeriolysin/recombinant produced listeriolysin. The culture medium and/or buffers are phosphate buffered saline (PBS), dulbeccos modified eagles medium (DMEM) rosswell park memorial institute medium (RPMI). The marker is used as a dye and/or a fluorescent compounds such as propidium iodide or similar. Independent claims are also included for: (1) a procedure for the production of an antigen presenting cells; (2) a procedure for the induction and/or activation and/or expansion of cytotoxic CD8+ T-cells; (3) a procedure for the determination of antigen epitope I-presented by major histocompability complex class; (4) a pharmaceutical composition; and (5) a kit.
This study aims to develop a cost-effective and reliable motion monitoring device capable of comprehensive fatigue analysis. It achieves this objective by integrating surface electromyography (sEMG) and accelerometer (ACC) signals through a feature fusion strategy. The study introduces a multi-level attention mechanism for classification, leveraging convolutional neural networks (CNNs). The preprocessing phase involves a local feature attention mechanism that enhances local waveform features using the amplitude envelope. A dual-scale attention mechanism, operating at both channel and neuron levels, is employed to enhance the model's learning from high-dimensional fused data, improving feature extraction and generalization. The local feature attention mechanism significantly improves the model's classification accuracy and convergence, as demonstrated in ablation experiments. The model, optimized with multi-level attention mechanisms, excels in accuracy and generalization, particularly in handling data with pseudo-artifacts. Computational analysis indicates that the proposed optimization algorithm has minimal impact on CNN's training and testing times. The study achieves recognition accuracies of 92.52%, 92.38%, and 92.30%, as well as F1-scores of 91.92%, 92.13%, and 92.29% for the three fatigue states, affirming its reliability. This research provides technical support for the development of affordable and dependable wearable motion monitoring devices.
A system for processing medical data related to a patient. The system includes an algorithm server, an adapter service, and at least one storage device. The algorithm server accepts input medical data and processes the input medical data to form output medical data. The adapter service provides the input medical data for use by the algorithm server. The adapter service comprises: (1) a controller for managing adapter service interaction with the algorithm server; (2) at least one input module communicating with an input apparatus over a network connection for obtaining patient data from the apparatus, and conditioning the patient data to form the input medical data for the algorithm server; and (3) at least one output module accepting the output medical data from the algorithm server, and conditioning the output medical data according to a data interchange standard. The storage device stores the input medical data obtained by the adapter service.