anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a Chinese traditional medicine combination pseudo-ginseng safflower blood invigorating capsule. The Chinese traditional medicine combination comprises pseudo-ginseng, frankincense, myrrh, safflower, hemlock parsley, rhubarb, peach seed, giant knotweed, teasel root, angelica and corydalis tuber. The invention also relates to the application of the Chinese traditional medicine combination in removing stasis, relieving pain and swelling, and bone-setting and application in preparation of medicines for treating blood stasis caused by diseases such as a fracture in junior high period, hyperosteogeny and joint regression. The experimental result proves that the Chinese traditional medicine combination provided by the invention containing different proportions enables the common Chinese herbal medicine to play a role in removing stasis, relieving pain and swelling, and bone-setting according to traditional Chinese medicine prescription. Eleven Chinese herbal medicines in the combination provided by the invention have wide medicine source and are easy to get, and the price is low. The combination also has the characteristics that the prescription is not complicated, the compatibility is reasonable, the curative effect is exact, the combination has no toxic and side effects, and the combination is easy to absorb. A preparation method of the combination provided by the invention is simple and easy to get, the prepared capsule is easy to dissolve in stomach intestine, unpleasant odor of the medicine is covered, and the medicine is convenient for patients to take.
<P>PROBLEM TO BE SOLVED: To provide a transmission service method that enables a doctor, etc., of a hospital to obtain secret document data such as a necessary medical chart in a short time and to acquire the details of the secret document data as a high-definition image, and to provide a device therefor.  <P>SOLUTION: When a page turn instruction 37 is given from a document data browsing terminal on the hospital's side, documents such as the medial charts set in an automatic document turn device 14 on the side of a warehouse company are turned. A moving image acquisition device 15 photographs data of the turned documents and transmits it in moving images. The moving images are displayed on a moving image display part 32. When a still image acquisition instruction 34 is given on the hospital's side, a still image acquired by a still image acquisition part 43 is encoded in a still image encoding part 44, transmitted to the hospital's side and displayed on a still image display part 39. When a camera control instruction 36 is given, control such as the position of a television camera of the moving image acquisition device 15, zoom-in, etc., is performed.  <P>COPYRIGHT: (C)2003,JPO
The researchers aim to evaluate the effectiveness of a home-based holistic progressive resistance exercise program for all lower extremity muscles (hip, knee and ankle circumference) in individuals with knee OA in detail and in a multifaceted manner. In addition, the researchers aim to examine the effect of exercise on serum biomarkers in order to understand whether exercise has an anti-inflammatory effect in these individuals and to establish standard exercise protocols. Thus, when a standard home-based exercise program can be established, it will be ensured that elderly individuals with knee OA, who have problems in reaching health centers, have difficulty in going out due to different health problems, and who are the primary care treatment, will be able to do exercises at home. At the same time, considering the global socioeconomic burden of knee OA, the researchers predict that the home-based exercise program will contribute positively to the country's economy.

All subjects who voluntarily accepted to participate in the study and met the inclusion criteria will be applied four times during the 12-week exercise program (except for the blood draw required for the evaluation of serum biomarker levels). Pain intensity, functional status based on performance and scales, quality of life, lower extremity range of motion, lower extremity muscle strength assessments will be repeated before treatment (0 weeks), 5th and 9th weeks, and after treatment (13th week). These assessments will be made at patients' homes. Blood collection will be done before treatment (week 0) and after treatment (week 13) to examine serum biomarker levels with ELISA kits.
The present invention relates to thiocarbamate derivatives of formula (I) which are useful as A2A adenosine receptor (A2AR) inhibitors (I). The invention relates in particular to a pharmaceutical composition comprising an inhibitor of A2A of formula (I) and a lipid carrier such as lauroyl macrogol-32 glyceride, D-alpha-tocopherol-polyethyleneglycol-1000 succinate or a mixture thereof. The pharmaceutical compositions of the present invention are particularly suitable for oral administration in the treatment of cancer. The invention also relates to a combination comprising an inhibitor of the A2A receptor of formula (I) and an anti-cancer agent. The anti-cancer agent is, for example, an immunotherapeutic agent, such as a checkpoint inhibitor. The invention further relates to pharmaceutical compositions and ingredients comprising said combinationA kit. Furthermore, the combinations of the invention are particularly suitable for the treatment and/or prevention of cancer.
This article aims to present growth curves for height, weight, and BMI of 95,000 Brazilian youths aged 6 to 17 years, including the five regions of the country, the Amazon region, and indigenous populations, and compare them with the World Health Organization (WHO) growth references. The final sample consisted of 52,729 boys and 42,731 girls from the "Projeto Esporte Brasil" database. Body mass and height information were used to derive the curves. The generalized additive model for location, scale, and shape was employed. In this study, we present smoothed weight-for-age, height-for-age, and BMI-for-age curves for boys and girls. Differences were observed between the results of the Brazilian curves and the WHO growth references. The developed curves will be valuable for professionals in medicine, public health, nutrition, physical education, and other related fields, regarding the assessment of physical growth in Brazilian children and adolescents and monitoring the nutritional status of this population. Additionally, these curves will facilitate the identification of individuals or subgroups at risk of diseases and delayed growth, with a greater focus on specific country-related factors.
The standard-of-care to evaluate patients for lip revision surgery relies on a subjective assessment by the surgeon of the static face. The important role of function or movement generally has been given far less consideration mainly because of the challenges faced by surgeons (e.g., the amount/quality of the tissue available to alter movement). Presently, even when surgeons do attempt to assess function, they do so in a subjective manner because there are no quantitative/visual aids to incorporate functional assessment into their treatment planning and decisions regarding lip surgery.

The Intervention approach proposed here has been refined sufficiently with surgeon feedback to allow surgeons to broaden their "vista" of the patients' 'movement and form' problems. Potentially, having identified a movement/form problem(s), surgeons could contemplate what needs to be done to improve patient specific problem(s). Importantly, pilot studies demonstrated that the Intervention had a definite impact on surgeons' decisions for lip revision: Surgeons substantially, but variably, changed their problem list and treatment planning goals. Thus, a goal of this study is to collect surgical outcome data which will be used primarily to monitor adverse events but also will provide preliminary information on improvement in patient outcomes (facial form and movement) when surgeons use the Intervention. In addition, given that revision surgery is very common after the primary lip repair, it is important to understand surgeons' decision-making with the use of the Intervention, to determine surgeons' goals and expectations for primary lip repair surgery, and to understand the surgical limitations that may lead to subsequent revision surgery.
Prophylactic antibiotics like third-generation cephalosporin is recommended for acute gastroesophageal variceal bleeding (GVB). Endoscopic sequential therapy is an option in the secondary prevention of acute gastroesophageal variceal bleeding (GVB). However, the value of prophylactic antibiotics in the endoscopic secondary prevention of GVB is still unclear. It's assumed that the procedure of needle puncture under endoscopy will cause iatrogenic variceal bleeding. Besides, the surface of intraluminal varices is nonsterile, and injection of sclerosing agent or tissue adhesive will put patients at a risk of bacteremia. As a result, it's rational to use antibiotics prophylactically in the endoscopic sequential therapy of GVB. While giving antibiotics in all patients might cause abuse of antibiotics. In clinical practice now, the prophylactic administration of antibiotics is quite subjective. We observe that quite a lot of cirrhotic patients had no infection after endoscopic secondary prevention for gastroesophageal variceal bleeding, even they have not been administered prophylactic antibiotics. In this non-inferiority trial, we are aimed to evaluate whether no value of prophylactic antibiotics will increase the postoperative infection or not, in the endoscopic secondary prevention of cirrhotic patients with gastroesophageal variceal bleeding.
The present invention relates to an active component of a wild opium poppy, an extracting method thereof, and the application thereof. The present invention breaks through the limit of a wild opium poppy which is only used as a folk medicinal herb, and provides a scientific basis and a scientific method for obtaining and using the active component of the whole herb of a wild opium poppy. In the present invention, an alcohol extraction method, a defatting method, a dissolution method, an alkalization method, an extraction method and other methods are adopted to obtain total alkaloid; after silicagel column chromatography, organic substance defatting and other steps, two new compounds (nudicaule alkali and nudicaulol) are obtained. After pathology researches and toxicological researches for monomers, an idea for developing products by using nudicaule alkali and nudicaulol is proposed. In addition, based on the pharmacal application of the total alkaloid of wild opium poppies using nudicaule alkali and nudicaulol as main components, a specific implementation scheme is proposed. The developed preparation has the effects of preventing cough, relieving asthma and killing pain, and can be widely used in the field of medical science.
VAL201-001 Sub-cutaneous injection. 8.0 mg/kg; potential to escalate to 16 mg/kg after 3 cycles according to clinician decision Flexibility of dosing enabled under protocol.
PURPOSE: The study aimed to determine the anxiety levels of caregivers who performed clean intermittent catheterization (CIC) on their children and the factors affecting them.
METHODS: This descriptive study was conducted between January 6, and May 29, 2023 with caregivers of 42 patients who were followed up by the pediatric nephrology outpatient clinic of a university for CIC. The study data were collected using the "Participant Information Form" and the "State and Trait Anxiety Scale."
RESULTS: According to the results, of the children included in the study, 73.8% were female, 64.3% were diagnosed with spina bifida (SB), and 76.2% received CIC applications 4-6 times a day. All the caregivers were mothers, and 76.2% received CIC training from a doctor. However, 78.6% of them found the training insufficient, leading them to rely on self-experimentation when applying CIC to their own children. None of the caregivers received information or training on the CIC application from nurses, and there were no home visits or telephone counseling provided after the hospital discharge. The mean score for the state anxiety scale among the caregivers was 45.90 ± 10.57, while the mean score for the trait anxiety scale was 46.92 ± 8.43. Significantly higher mean trait anxiety scores were observed among caregivers with chronic diseases who did not receive training on the CIC application (p < 0.05). Additionally, caregivers of children who experienced 3-4 urinary tract infections (UTIs) within the last 3 months also had significantly higher mean trait anxiety scores (p < 0.05). The mean trait anxiety level scores of caregivers of children who had 3-4 UTIs in the last 3 months were significantly higher (p < 0.05).
CONCLUSIONS: It was concluded that caregivers' lack of training on CIC implementation, having chronic disease, and having frequent UTIs in their children were effective on anxiety levels.
Erector spinae plane block has successfully been demonstrated to provide an efficient analgesia in patients with rib fracture, open thoracotomy, breast surgery. The present study is aimed to investigate the intraoperative hemodynamic responses, anesthetic and analgesic consumption, and postoperative recovery quality of erector spinae plane block in patients with knee prosthesis. After approval, patients enrolled in the study are divided into two groups by computer-based randomization technique as control and study group. After standard monitorization, anesthesia induction and tracheal intubation, erector spinae plane block is performed to study group and no intervention to control group.

In the intraoperative period, 10 mg / kg paracetamol and 0.05 mg / kg morphine will be used for postoperative analgesia. After surgery, all patients will be given 10 mg/kg paracetamol every 8 hours and will be fitted with a patient-controlled analgesia (PCA) device (Tramadol HCL). PCA device bolus dose will be set to 20 mg, lock time will be set to 10 minutes and the number of buttons per hour will be set as 3.for postoperative analgesia.After surgery, VAS scores of the patients will be evaluated (in the recovery room, 1,3,6,12 and 24 hours, Patients with VAS≥4 will be given 0.03mg / kg morphine as salvage analgesia.After 30 minutes, the patients' VAS will be re-evaluated,If VAS≥4 the same dose will be repeated.
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that one-third of the human population is incurably infected with the feline-borne parasite, Toxoplasma gondii, which can invade the central nervous system and result in chronic low-grade neuroinflammation, oxidative stress, and excitotoxicity-all of which are also important pathophysiological processes in TBI. Considering the large number of TBI patients that have a pre-existing T. gondii infection prior to injury, and the potential mechanistic synergies between the conditions, this study investigated how a pre-existing T. gondii infection modified TBI outcomes across acute, sub-acute and chronic recovery in male and female mice. Gene expression analysis of brain tissue found that neuroinflammation and immune cell markers were amplified in the combined T. gondii + TBI setting in both males and females as early as 2-h post-injury. Glutamatergic, neurotoxic, and oxidative stress markers were altered in a sex-specific manner in T. gondii + TBI mice. Structural MRI found that male, but not female, T. gondii + TBI mice had a significantly larger lesion size compared to their uninfected counterparts at 18-weeks post-injury. Similarly, diffusion MRI revealed that T. gondii + TBI mice had exacerbated white matter tract abnormalities, particularly in male mice. These novel findings indicate that a pre-existing T. gondii infection affects the pathophysiological aftermath of TBI in a sex-dependent manner, and may be an important modifier to consider in the care and prognostication of TBI patients.
The invention discloses a production method of an attapulgite traditional Chinese medicine toothpaste. The key point of the technical proposal of the production method is that the method consists of the steps of ingredients preparing, low-speed stirring, crushing and pulping, grinding, high-speed stirring, vacuum degasification and the canning of the finished product. The attapulgite traditional Chinese medicine toothpaste consists of paste attapulgite clay, herba cirsii japenici, flos sophorae, hawthorn, baked rhizoma zingiberis, rhizoma imperatae, Chinese arborvitae twig, notoginseng, licorice, borneol, lauryl sodium sulfate, potassium sorbate and deionized water. The attapulgite traditional Chinese medicine toothpaste is characterized by softness, delicacy, small friction hardness, clean and uniformity, good absorption ability and no roughness; the invention is also characterized in that the paste does not spill over the tube, no water is separated, the flavor and color is normal, and the glassslide does not have any nick. The attapulgite traditional Chinese medicine toothpaste can absorb and remove various odors in oral cavity and also contributes to oral diseases prevention.  The invention is suitable for producing attapulgite traditional Chinese medicine toothpaste, traditional Chinese medicine toothpaste and other medicinal toothpastes.
Bifidobacterium longum spp. longum R0175, Bifidobacterium animalis spp. Lafti B94, Bifidobacterium bifidum R0071 at 3x10\^9 CFU/d plus resistant starch type 2, arabinoxylan, and galactooligosaccharide at 24 g/d will serve as the treatment.
<P>PROBLEM TO BE SOLVED: To provide a prodrug of a sulfonamide acting as an aspartyl protease inhibitor.  <P>SOLUTION: An embodiment of the invention is a new prodrug of an HIV aspartyl protease inhibitor characterized by a desirable water-solubility, high peroral bioavailability and easy in vivo generation of an active component. The invention further relates to a pharmacological composition containing the prodrug. The prodrug and the pharmacological composition are especially effective for lowering disagreeable load (pill burden) and increase the drug-taking ratio (patient compliance). The invention further relates to a method for treating a mammal with the prodrug or the pharmacological composition.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
NLRs constitute a large, highly conserved family of cytosolic pattern recognition receptors that are central to health and disease, making them key therapeutic targets. NLRC5 is an enigmatic NLR with mutations associated with inflammatory and infectious diseases, but little is known about its function as an innate immune sensor and cell death regulator. Therefore, we screened for NLRC5's role in response to infections, PAMPs, DAMPs, and cytokines. We identified that NLRC5 acts as an innate immune sensor to drive inflammatory cell death, PANoptosis, in response to specific ligands, including PAMP/heme and heme/cytokine combinations. NLRC5 interacted with NLRP12 and PANoptosome components to form a cell death complex, suggesting an NLR network forms similar to those in plants. Mechanistically, TLR signaling and NAD+ levels regulated NLRC5 expression and ROS production to control cell death. Furthermore, NLRC5-deficient mice were protected in hemolytic and inflammatory models, suggesting that NLRC5 could be a potential therapeutic target.
To generate a new murine model for virus, DC-SIGN gene in murine was humanized. In this study, we successfully generated a humanized C57BL/6N mouse model expressing human DC-SIGN (hDC-SIGN) using CRISPR/Cas9 technology, and evaluated its characters and susceptibility to virus. The humanized mice could survival as usual, and with normal physiological index just like the wild-type mice. Whereas, we found significant differences in the intestinal flora and metabolic profiles between wild-type mice and humanized mice. Following intranasal infection with SARS-CoV-2, hDC-SIGN mice exhibited significantly increased viral loads in the lungs and nasal turbinates, along with more severe lung damage. This phenomenon may be associated with differential lipid metabolism and Fcγ receptor-mediated phagocytosis in two mouse models. This study provides a useful tool for investigating the mechanisms of coronavirus infection and potential drug therapies against novel coronavirus.
Compulsive hoarders perform significantly worse than healthy controls on standard attention tasks. These data suggest that the inability to sustain focus may interfere with hoarders' ability to organize, categorize and make decisions about discarding possessions. Stimulants are first-line treatments for ADHD, improve CPT performance in people with ADHD and enhance school performance in children with ADHD. Extended release formulations, such as methylphenidate ER, are associated with better medication compliance. Together, these data suggest that adjunctive methylphenidate ER might be a novel way to improve attention in compulsive hoarders which might improve hoarding symptoms.

The investigators hypothesis is that adjunctive methylphenidate ER will improve attention in compulsive hoarders aged 18-55. The investigators will also explore the safety of methylphenidate ER administration in compulsive hoarders.
Myocardial ischemia (MI) is a significant contributor to ischemic heart diseases like angina pectoris and myocardial infarction. Reactive oxygen species produced during MI can trigger lipid peroxidation, damaging cell structure and function. Salvia miltiorrhiza (SM) has been widely used clinically in the treatment of cardiovascular diseases. However, in the process of rooting, the aboveground parts of this plant are usually discarded by tons. To make better use of these plant resources, the phenolic acids extracted and purified from the aerial part of SM were studied and chemically transformed, and the potential protective effect and possible mechanism of salvianolic acids containing a higher content of salvianolic acid A on MI were obtained. The transformed products of SM stem-leaves total phenolic acids with 8.16 % salvianolic acid A showed a better protective effect on the isoproterenol (ISO)-induced acute MI injury rat model. It can improve ST segment changes and has good antioxidant, anti-inflammatory and anticoagulant effects. In addition, the dysbiosis of gut microbiota and the related metabolic levels of short chain fatty acids (SCFAs), phenylalanine and glycerophospholipids were improved. This was achieved by reducing the abundance of Bacteroides, Faecalibaculum, and L-phenylalanine levels. In addition, the abundance of probiotics in Butyricoccus, Roseburia, and norank_f_Eubacterium_coprostanoligenes_group, as well as the contents of propionic acid and isobutyric acid, LPCs and PCs were increased. In conclusion, total phenolic acids of SM stem-leaves showed protective effects against ISO-induced rats, especially the strongest effect after conversion, which is a new option for the prevention and treatment of MI.