anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In order to achieve the above object, the invention provides a technical scheme for a traditional Chinese medicine prescription for treating the rhagades of hands and feet. The traditional Chinese medicine prescription for treating the rhagades of hands and feet is characterized by comprising the following components of notopterygium root, ledebouriella root, schizonepeta, dahurian angelica root, asarum herb, cortex dictamni, rhizoma kaempferiae, radix clematidis, raw fleece-flower root, chinese angelica, raw liquorice and cinnamon. The weights of all the above components are as follows: 150 g of notopterygium root, 150 g of ledebouriella root, 150 g of schizonepeta, 90 g of dahurian angelica root, 15 g of asarum herb, 150 g of cortex dictamni, 150 g of rhizoma kaempferiae, 30 g of radix clematidis, 120 g of raw fleece-flower root, 180 g of chinese angelica, 60 g of raw liquorice and 20 g of cinnamon. The preparation and administration method of the traditional Chinese medicine prescription comprises the steps of drying, mixing up and crushing all above components, sieving materials by a 80-mesh sieve, and filling medicine powders into a bottle for later use. During usage, two hands/feet are soaked in a proper amount of hot water for 30 minutes firstly, and then the two hands/feet are wiped dry. After that, 30 grams of the above medicine powders are adopted and mixed evenly with petrolatum. Finally, an obtained mixture is applied externally onto an affected part once a day for continuous 10 days a course. The problem in the prior art that existing pharmaceutical drugs cannot radically cure the rhagades of hands and feet can be solved. The traditional Chinese medicine prescription can be used for treating the rhagades of hands and feet.
PURPOSE OF REVIEW: Tension-type headache (TTH) continues to be the most prevalent type of headache across all age groups worldwide, and the global burden of migraine and TTH together account for 7% of all-cause years lived with disability (YLDs). TTH has been shown to have a prevalence of up to 80% in several studies and presents a wide range and high variability in clinical settings. The aim of this review is to identify gaps in diagnostics, nosology, and variability in the treatment of children and adolescents who present with headaches without an identifiable etiology.
RECENT FINDINGS: Migraine and TTH have been debated to have more similarities than distinctions, increasing chances of misdiagnosis and leading to significant cases diagnosed as probable TTH or probable migraine. The lack of specificity and sensitivity for TTH classification often leads to the diagnosis being made by negating associated migraine symptoms. Although pathology is not well understood, some studies have suggested a neurological basis for TTH, in need of further validation. Some research indicates that nitric oxide signaling plays an integral part in the pain mechanisms related to TTH. Analgesics and non-steroidal anti-inflammatories are usually the first lines of treatment for children with recurring headaches, and additional treatment options include medication and behavioral therapies. With high prevalence and socioeconomic burden among children and adolescents, it's essential to further study Tension-type headaches and secondary headaches without known cause and potential interventions. Treatment studies involving randomized controlled trials are also needed to test the efficacy of various treatments further.
Scoliosis is a malformation of the musculoskeletal system that is defined by lateral deviation of the spine, which is typically accompanied by vertebral rotation and lordosis. The term "scoliosis" refers to the curvature of the spine that results from the condition (3-dimensional deformity). Scoliosis in female teenagers often reaches its most advanced stage between the ages of 11 and 16 years old. In general, scoliosis may be broken down into two categories: structural and non-structural scoliosis. The level of severity and the degree of deformity of the spine are the major characteristics that differentiate the two groups. It is common practice to refer to the structural type of scoliosis as a sort of spinal deformity that cannot be corrected without surgical intervention. Bracing, exercises, and education are some of the conservative treatments that may be used to control non-structural spinal deformity, which is a movable disorder. Scoliosis that is not treated properly may advance to a functionally degraded condition, which is characterized by physical asymmetry, muscular imbalance, back discomfort, and considerable respiratory disruption. This can lead to distorted body image and a loss of self-esteem in the patient. Idiopathic adolescent scoliosis, more commonly known as AIS, is the diagnosis that is typically made in children who are otherwise healthy but have a spinal curvature of at least ten degrees but less than fifty degrees. This curvature range is what determines whether a child is considered to have AIS. While treating scoliosis, the primary goal of therapy should be to slow or stop the disease's development so that the treatment may be regarded effective. Non-conservative therapies often entail surgical techniques for the correction of spinal abnormalities; nevertheless, these operations do not come without associated risks. Individuals who arrive with a scoliosis curvature of less than 40 degrees have the potential to be candidates for conservative treatments such as physiotherapy scoliosis-specific exercise (PSSE), with or without the concomitant use of an external brace.
BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type 2 airway inflammation. Tobacco exposure can lower FeNO levels. However, the effect of acute tobacco exposure on FeNO in patients with chronic obstructive pulmonary disease (COPD) is unclear. This study aimed to investigate the relationship of acute tobacco exposure with FeNO and eosinophils in COPD patients.
METHODS: This retrospective cohort study included 445 patients with COPD based on the 2007-2012 National Health and Nutrition Examination Survey. Serum cotinine levels were examined to assess environmental tobacco smoke exposure. The patients were divided into five groups based on cotinine levels: Q1 (first quintile), Q2 (second quintile), Q3 (third quintile), Q4 (fourth quintile) and Q5 (fifth quintile). Logistic regression models and linear logistic regression models were used to evaluate the relationship between serum cotinine and FeNO and EOS levels.
RESULTS: Approximately 16.5 % (75/445) of the participants had elevated FeNO (>25 bbp). In the unadjusted model, COPD patients with the lowest quintile of serum cotinine levels (0.011-0.0185 ng/mL) had higher FeNO levels compared to those with the highest quintile (≥309 ng/mL) (odds ratios (OR), 5.86 [2.11-16.20]). These findings remained consistent even after adjusting for covariates of demographics, lifestyle, diabetes, coronary heart disease, tumours, hypertension, using oral or inhaled steroids within 2 days, asthma and respiratory symptoms within 7 days. Furthermore, a standard deviation increase of ln-transformed cotinine levels was associated with decreased FeNO levels (OR, 0.45 [0.33, 0.60]). No significant correlation was observed betweenserum cotinine and blood eosinophils. After high extents of tobacco exposure, no correlation was found between FeNO and eosinophils. Our findings indicate that high cotinine levels are associated with decreased FeNO in COPD patients but not with blood eosinophils. This reveals that smoking may affect FeNO levels in patients with COPD, whereas it does not appear to influence blood eosinophil levels.
The present invention discloses a kind of Chinese medicine composition treating chronic cholecystitis, is made up of the bulk drug of following weight part: the stem pith of the rice-paper plant 5��15 parts, Semen Coicis 5��10 parts, the coptis 5��10 parts, Seed of Chinese Soapberry 2��6 parts, Sediment of human urine 2��6 parts, garden burnet 5��10 parts, Semen Vaccariae 5��15 parts, Chinese cassia tree 2��6 parts, cassia twig 5��10 parts, Herba Centellae 5��10 parts, dried orange peel 3��8 parts, Radix Codonopsis 3��8 parts, borneol 0.2��0.5 part. Preparation method is: get each bulk drug, and mixing, is ground into smalls, makes powder, to obtain final product. During treatment, oral, every day twice, each 5 grams. It within 15 days, it is a course for the treatment of. State of an illness the lighter cures 2��3 courses for the treatment of, and state of an illness severe one is cured 4��6 courses for the treatment of. The Chinese medicine composition of the treatment chronic cholecystitis of the present invention, scientific formula used is rigorous, with strong points, and cost is low, without any side effects, good effect, therapeutic process no pain, simple to operate.
This is a dose escalation study of IMRT for women with locally advanced cervical cancer. Three dose levels will be investigated, (although, the first dose level is considered to be the equivalent to a standard pelvic dose with parametrial boost). Before moving to the next dose level it must be confirmed by the Chief Investigator that the Maximum Administrable Dose (MAD) has not been met in the previous dose level (see section 6.3). If MAD is reached before dose level 3 the study will stop. All patients enrolled on the study will undergo the same procedures at the same time points, regardless of the dose level they are being given (see section 5).
BACKGROUND: Kidney transplantation is the treatment of choice for people living with kidney failure who are suitable for surgery, but survival benefits for older and/or ethnic minority candidates are unclear. To inform decision-making, the survival of patients on a waiting list for kidney transplantation was assessed.
METHODS: A retrospective study was undertaken of registry data for patients with kidney failure listed for transplantation in the UK. From 1 January 2000 until 30 September 2019, all patients listed for a first kidney-alone transplant were included. The primary outcome was all-cause mortality. After testing for violations of the proportional hazards assumption, an extended Cox regression model factoring in transplantation as a time-dependent variable according to the intention-to-treat principle was developed.
RESULTS: The study cohort included 47 917 patients on a waiting list for kidney transplantation, of whom 34 558 (72.1%) subsequently received a transplant. Transplantation compared with remaining on dialysis was associated with an overall survival benefit (HR 0.17, 95% c.i. 0.16 to 0.18; P < 0.001), occurring immediately within 30 days, and observed regardless of ethnicity. For White kidney transplant candidates aged at least 65 or at least 70 years, a significant survival benefit was observed within 6 months (HR 0.49, 0.29 to 0.82) and 1 year (HR 0.45, 0.25 to 0.79) after transplantation respectively, which contrasted with 3 years after kidney transplantation for candidates from ethnic minorities aged at least 65 years (HR 0.53, 0.36 to 0.78) or at least 70 years (HR 0.53, 0.36 to 0.78).
CONCLUSION: Although time-to-survival benefits are stratified by age and ethnicity, all kidney transplant candidates on the waiting list are better off with transplantation compared with remaining on dialysis. The absence of any early postoperative mortality suggests that some high-risk patients with kidney failure may not be receiving transplantation opportunities.
Health disparities are high among Latinas. They are more likely to be overweight, diagnosed with diabetes, and physically inactive compared to their non-Hispanic White counterparts. Thus, interventions that target improving health access and ameliorating chronic diseases among Latinas are of high public health importance. Available data suggest that community-focused interventions produce improvements in physical activity (PA) and are well-received by Latinas especially when social and physical environments are considered (e.g., social support, safe walking areas, etc.). Research suggests that Latinos respond favorably to technological-based health interventions. Thus, health promotion interventions that can address Latinos' preferences regarding their physical and social environments while utilizing a preferred technology source (e.g., smartphone) could prove highly successful. In a Phase I SBIR, our team developed ¡Caminemos Juntas!, an innovative mobile phone app using Location-based Services (LBS) to connect women within geographically proximal neighborhoods as a way to provide social support for increased walking behaviors. Specifically, we (a) gathered feedback from an Expert Advisory Board (EAB) to help plan and assess the feasibility of creating the app; (b) built connections and gathered input from Latina community leaders to assist in the conceptual development of the app through a Community Advisory Board (CAB); (c) conducted an online survey of a national sample of Latinas on their smartphone usage for health promotion, and interest in social networking and LBS technology features; (d) conducted iterative focus groups with Latinas to guide development of app content, design, and aesthetics to fully develop a functioning prototype; (e) conducted field usability testing with Latinas to test the app's accuracy to establish users' location and connect users through the ¡Caminemos Juntas! system and users' use and satisfaction with the app; and (f) developed a specifications document to outline the Phase II development plan. The results of the Phase I activities provided strong support for this Phase II SBIR application. The proposed Phase II project will (1) develop a full-scale, fully programmed ¡Caminemos Juntas! app; (2) determine whether the ¡Caminemos Juntas! app can be translated and adapted to a new community environment; (3) test the performance, usage, and usability of the full-scale, fully-programmed app; and (4) evaluate whether ¡Caminemos Juntas! increases physical activity, social support for exercise, and quality of life (QOL) in Latinas. ¡Caminemos Juntas! will be evaluated in a randomized comparative-effectiveness trial (n=200) with Latinas age 18-55 in the Denver, CO and San Jose, CA areas. Overall, the proposed project has the potential to significantly impact Latinas' health by providing them with real-time opportunities to connect socially with the goal of walking. ¡Caminemos Juntas! will be the first app that use geo-location technology dedicated to walking with a social emphasis, for any population.
Patients with left ventricular wall thickness measuring 15mm or more, or patients with a suggestive left ventricular echogenicity. Procedure/surgery will be performed following a diagnostic tree.
The utility model relates to a medical flocked hemostasis material for hemostasis and protection of artery, vein and tissue wounds, application of the medical flocked hemostasis material and a production method of the same. The medical flocked hemostasis material comprises a flocked layer serving as a wound contacting layer and a base layer. The flocked layer is made of functional fiber. The functional fiber is fixed on the upper surface of the base layer by flocking. The flocking includes mechanical flocking and electrostatic flocking. The medical flocked hemostasis material is applicable to hemostasis and protection of artery, vein and tissue wounds, and can be used as a drug slow-release carrier. The utility model further discloses a method for controlling arterial hemorrhage, venous hemorrhage and tissue wound hemorrhage with the medical flocked hemostasis material. Compared with the hemostasis material in the prior art, the medical flocked hemostasis material is better in hemostasis performance and comfort.
Patients participate in RE sessions 3 times per week for 12 weeks. After 12-weeks, non-responders may participate in a further 12-weeks of combined AE and RE sessions, while responders continue participating in the RE sessions alone for an additional 12 weeks.
A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II antagonist. This method of treatment can be used in conjunction with the treatment of hypertension. Substituted imidazoles such as (i) are useful as angiotensin II receptor antagonists for this method of treatment. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor and an angiotensin converting enzyme inhibitor. Also within the scope of this invention are pharmaceutical compositions for this method of use.
NACl 100 ml IV. 3 infusions. Administration 3 times over two years.
PURPOSE: To evaluate the outcome of apexification using bioceramics in immature permanent teeth, and to study the factors influencing treatment outcome and frequency of spontaneous cervical root fractures.
METHODS: Forty-six children with 51 non-vital permanent incisors treated with a bioceramic apical plug were included. Mean age at pulp necrosis was 9.8 (SD 2.2) years and mean follow-up time was 3.3 (SD 2.4) years. Data were extracted from dental records and included stage of root development, presence of external root resorptions, clinical signs of infection, size of periapical lesion, type and placement of bioceramic plug, and spontaneous root fracture. Treatment outcome was assessed using periapical index (PAI-score) and presence of clinical symptoms. The statistical analyses were conducted using IBM SPSS Statistics for Windows, version 28 (IBM Corp., Armonk, N.Y., USA). Data were cross-tabulated and tested with chi-square statistic.
RESULTS: Biodentine™ was used as apical plug in 78.4% of the teeth and MTA in 21.6%. Complete healing or signs of healing was reported in 86.3% of the teeth, whilst seven teeth (13.7%) were non-healed. All non-healed teeth had preoperative clinical signs of infection. No difference was found in stage of root development, presence of root resorption, and type and placement of bioceramic plug in healed and non-healed teeth (p > 0.05). Five teeth (9.8%) exhibited root fracture 1-6 years after treatment and all had very immature root development. Type of bioceramic or external root resorption was not associated with spontaneous root fracture.
CONCLUSION: Apexification using bioceramics showed favourable prognosis in immature permanent teeth. Very immature teeth were at risk of root fracture after apexification with bioceramics.
The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. 

In the event of overdosage, symptomatic and supportive measures should be employed. Correct dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. If required, give oxygen or artificial respiration for respiratory impairment. 

The degree to which chlorothiazide sodium is removed by hemodialysis has not been established. The intravenous LD50 of chlorothiazide in the mouse is 1.1 g/kg.
Standard Chemo Prep Regimen(SCPR)+Retreat. Young TIL+High Dose(HD) Interleukin-2, SCPR. Young TIL+HD Interleukin-2, SC(Retreat). SCPR+Young TIL Cells retreatment with SCPR+Young TIL Cells+pembrolizumab. Aldesleukin:720,000 IU/kgIV every eight hours (+/-1 hour) beginning within 24 hours of cell infusion and continuing for up to 4 days (maximum 12 doses). Fludarabine:25 mg/m\^2/day intravenous piggy-back(IVPB) daily for 5 days. Cyclophosphamide:60 mg/kg/day X 2 days IV. Young TIL:Day 0: Cells will be infused IV. Retreatment with standard preparative regimen+Young TIL Cells+pembrolizumab. Aldesleukin:720,000 IU/kg IV every eight hours (+/- 1 hour) beginning within 24 hours of cell infusion and continuing for up to 4 days (maximum 12 doses). Fludarabine:25 mg/m\^2/day intravenous piggy-back (IVPB) daily for 5 days. Cyclophosphamide:60 mg/kg/day X 2 days IV. Young TIL: Day 0:Cells will be infused IV. Pembrolizumab:2 mg/kg IV on Days -2, 21 (+/- 2 days), 42 (+/- 2 days), and 63 (+/- 2 days).
1448165 1 - Substituted - 5 - (substituted phenyl) - 3 - methyl - 1,3,5 - triazapenta - 1,4- dienes and their acaricidal compositions PFIZER Ltd 21 Aug 1975 [23 Aug 1974] 37232/74 Heading C2C The invention comprises compounds of general Formula I and their salts with weak dibasic organic acids wherein R1 is a C 1-4 alkyl group; R2 is a hydrogen or halogen atom or a C 1-4 alkyl group; R3 is a C 4-10 cycloalkyl group optionally substituted by a halogen atom or a C 1-4 alkyl group, a C 1-4 alkyl group substituted by an aryl group; or a C 1-4 alkyl group substituted by a C 4-10 cycloalkyl group, said cycloalkyl group optionally being substituted by a C 1-4 alkyl group or a halogen atom and R4 is a hydrogen atom, a C 1-4 alkyl group or a group of formula SR5 in which R5 is a hydrogen atom or a C 1-4 alkyl group. Compounds of Formula I in which R4 is hydrogen may be prepared by reacting a formamidine of Formula II with an isonitrite of formula R3 NC in the presence of a catalyst such as CuO or Cu 2 Cl 2 . Compounds in which R4 is a hydrogenation or a C 1-4 alkyl group may be prepared (a) by reacting a compound of Formula II (above) with an imidate of Formula III in which R6 is a C 1-4 alkyl group by heating; (b) by heating a compound of Formula IV in which R7 is a C 1 alkyl group with an amidine of Formula V or (c) by reacting an amidine of Formula III (above) with an isonitrile of Formula VI in the presence of a catalyst, e.g. CuO or Cu 2 1Cl 2 . Compounds of Formula I in which R4 is a group of formula SR5 may be prepared by reacting a formamidine of Formula II (above) with an isothiocyanate of formula R3NCS to obtain a product in which R5 is hydrogen followed, if desired by 5-alkylation. N - Cyclohexyl - N1 - methylacetamidine is obtained by reaction of methyl N-methylacetimidate with cyclohexylamine. N-Cyclohexylformamide is prepared by reaction of formic acid with cyclohexylamine and is further reacted with triethyloxanium fluorborate to obtain ethyl N-cyclohexylformimidate. N - Methyl - N1 - (2,4 - dimethylphenyl)- formamidine is prepared by reaction of 2,4- xylidine hydrochloride with N-methylformamide in the presence of benzenesulphonylchloride. Acaricidal and insecticidal compositions comprise a compound of Formula I together with a diluent or carrier.
Patients in the FA Pneumonia Panel guided group will have a BioFire® FilmArray® Pneumonia Panel assay performed as soon as possible but within 24 hours of new antibiotic prescription for suspected respiratory infection in addition to all the investigations performed in standard care. Based on the rapid test results, antimicrobial therapy will be adjusted according to a pre-determined treatment algorithm and antimicrobial guidelines. The treatment algorithm and antimicrobial guidelines were based on the latest hospital antibiogram, procalcitonin protocol, and consensus recommendations from microbiologists, infectious disease experts and intensive care physicians at our hospital. The treating clinical team will also be given the standard microbiological culture with sensitivity results when available. The treating clinical team may override the pre-determined antimicrobial algorithm for any clinical reason at any time and the rationale will be recorded.
Failure to close the PDA in premature neonates in a timely fashion can lead to pulmonary over-circulation and systemic under-circulation. The PDA often fails to close using currently approved Ibuprofen dosing regimens, and surgical closure becomes necessary. Ibuprofen clearance in premature neonates is significantly correlated with postnatal age, increasing rapidly over time. Hirt et al. published and optimized dosing scheme for preterm neonates based on pharmacokinetic and pharmacodynamic data. We aim to use this dosing regimen in the clinical setting to determine if increased rates of pharmacologic PDA closure can be achieved.