anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Waist-related measures are commonly used to classify central adiposity and related comorbidities. This classification may be essential among children, as it may identify the risk of future non-communicable diseases.
METHODS: A cross-sectional study was conducted in the Eastern Cape province, South Africa, among 459 primary school learners aged 9-14 years. Height, weight and waist circumference (WC) were measured using standardised techniques recommended by World Health Organization (WHO). The anthropometric measurements, including body mass index (BMI), WC, waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were computed and evaluated.
RESULTS: Most participants were girls (57.70%) with an average age of 11.20 ± 1.60 years. The average weight was 38.81 kg ± 10.49 kg with an average height of 144.16 (standard deviation [s.d.] = 10.37) cm. The sample had a BMI of 18.41 kg/m2 (s.d. = 3.19). The results showed, on average, WC of 62.10 cm ± 8.12 cm, WHR of 0.82 ± 0.15 and WHtR of 0.44 ± 0.05. Girls reported significantly higher BMI, WC and WHtR. Based on WHtR, the results showed the acceptable ability to classify children according to abdominal obesity, thus identifying their risk for comorbidities.
CONCLUSION: Overall body fat indicated by BMI and central obesity shown by waist-related anthropometric measures can play a significant role in classifying children in terms of their risk of comorbidities.Contribution: To prevent the risks of metabolic diseases in childhood, it is necessary to detect abdominal obesity early using WC-based anthropometric measurements, especially WHtR, to identify those at risk.
<P>PROBLEM TO BE SOLVED: To provide a nutritional preparation for cerebrospinal nerve for promoting RNA nutritional effect.  <P>SOLUTION: This nutritional preparation for cerebrospinal nerve is used also as a nutritional supplement food product and comprising RNA, ribonucleotide and/or ribonucleoside (hereafter, referred to as RNA, and/or the like) in the form of powder, L-arginine powder, and L-ascorbic acid powder at 0.2-20 wt. time(s) the L-arginine powder. Incorporation of the L-arginine powder promotes the nutritional effect by the RNA, and/or the like. The incorporation of the L-ascorbic acid eliminates the harsh taste inherent in L-arginine, mitigates the harsh feeling of the stomach (heartburn, nausea, vomiting, or the like) and has the preventing effect on cytotoxicity that may be caused by intake of a large amount of L-arginine. Further, by making the form of the three components, i.e., the RNA, and/or the like, L-arginine and L-ascorbic acid, into dry powder, this nutritional preparation can avoid its getting brownish due to long-term storage.  <P>COPYRIGHT: (C)2004,JPO
BACKGROUND: Encorafenib-cetuximab has been approved for pretreated BRAFV600E-mutated metastatic colorectal cancer (mCRC) patients based on efficacy demonstrated in the randomized phase III BEACON trial. The aim of this real-world effectiveness study is to improve knowledge on the generalizability of trial results.
METHODS: This population-based real-world study includes all mCRC patients in the Netherlands treated with encorafenib-cetuximab since approval. Individual patient data and pathology reports were collected. Overall survival (OS) was compared to BEACON and subgroup analyses were conducted for patients who would have been eligible and ineligible for BEACON.
RESULTS: 166 patients were included with a median follow-up time of 14.5 months. Median OS was 6.7 months (95% CI:6.0-8.3) and differed from BEACON (9.3 months; 95% CI:8.0-11.3, p-value 0.002). Thirty-six percent of real-world patients would have been ineligible for the BEACON trial. Trial ineligible subgroups with symptomatic brain metastases and WHO performance status ≥2 had the poorest median OS of 5.0 months (95% CI:4.0-NR) and 3.9 months (95% CI:2.4-NR).
CONCLUSION: This real-world cohort of mCRC patients treated with encorafenib-cetuximab showed a clinically relevant efficacy-effectiveness gap for OS. The chance of survival benefit from encorafenib-cetuximab in patients with brain metastases and/or WHO performance status ≥2 is negligible as neither efficacy nor effectiveness has been demonstrated.
Fluid overload is a common and serious complication in patients admitted to the intensive care unit (ICU). A core element of therapy in the ICU is resuscitation with crystalloid solutions. In many cases fluid accumulate, and patients become fluid overloaded. Several observational studies indicate a detrimental effect of fluid overload in different clinical settings, including patients with acute kidney injury. It is unknown whether this association is causal or if the increased tendency to accumulate fluid is a marker of disease severity and thereby a higher risk of death. The investigators want to investigate this in critical ill patients with fluid overload of 5% or more by randomizing them to furosemide (diuretics) or placebo.
The invention discloses an oral prescription of traditional Chinese medicine used for treating leukemia, which belongs to a field of traditional Chinese medicine.The oral prescription of traditional Chinese medicine used for treating leukemia is made from effective component of the material with the weight account: 25g Chinese angelica, 15g poria, 15g pulp of dogwood fruit, 20g thunberg fritillary bulb, 20g polygonatum root, 30g barbated skullcup herb, 3g natural indigo, 12g honeysuckle flower, 15g lilyturf root, 15g thinleaf milkwort root, 30g hedyotis, 10g moutan bark and 10g red peony root. Putting the material medicine into a marmite and adding water for proper soaking: first, using furious fire to boil, then using small fire to heat for half an hour. The liquid medicine is filtered, and proper water is added into the decoction medicine and heated for half an hour, and then the medicine liquid is filtered again. The liquid medicine obtained from the two steps is mixed together and is cooled. The medicine is respectively served half an hour before breakfast and two hours after supper. The invention is characterized by rich material, low price, easily obtaining and no toxic and side efforts.
Novel acid addition salts of barbituric acid derivatives of the general formula <FORM:1104688/C2/1> wherein R1 represents H or an aliphatic radical (defined as comprising C1- 8 alkyl groups, cycloaliphatic radicals, cycloaliphatic-aliphatic radicals and carbocyclic aryl-aliphatic radicals), A represents an ethylene or trimethylene radical optionally substituted by one or more methyl groups, and R2 represents a phenyl group optionally substituted by one or more halogen, OH or C1- 4 alkyl or alkoxy substituents, are prepared by catalytically hydrogenating acid addition salts of barbituric acid derivatives of the general formula <FORM:1104688/C2/2> (wherein R3 represents an arylmethyl or heterocyclylmethyl group when R1 is to be H, or an "aliphatic" radical when R1 is to be an "aliphatic" radical, and Z represents an arylmethyl or heterocyclylmethyl radical), which in turn may be prepared by condensing a malonic ester of the general formula <FORM:1104688/C2/3> (wherein R is a C1- 4 alkyl group) with urea, or with thiourea at - 10 DEG  to +35 DEG  C., followed by oxidation of the resulting 2-thiobarbituric acid compound with an acidic oxidant. Malonic esters of the last general formula above are prepared by condensing an aminoalkyl chloride R3ZN-A-Cl with a mono-substituted malonic ester R2CH(COOR)2.  Aminoalkyl chlorides R3ZN-A-Cl are prepared by treating the corresponding alkanolamines with SOCl2 and liberating the desired bases from the resulting hydrochlorides thereof.  N - Methyl - N - furfuryl - 2 - aminoethanol is prepared by condensing 2-bromoethanol with N - methylfurfurylamine in n - propanol and adding anhydrous K2CO3.  Pharmaceutical compositions comprise acid addition salts of the compounds of the first general formula above in association with pharmaceutical carriers therefor. They may be in forms suitable for oral, parenteral or rectal administration, and are useful as anticonvulsants and as agents for the relief of Parkinsonian symptoms
BACKGROUND: The long-term sequelae of COVID-19 in children and adolescents remain poorly understood and characterized. This systematic review and meta-analysis sought to summarize the risk factors for long COVID in the pediatric population.
METHODS: We searched six databases from January 2020 to May 2023 for observational studies reporting on risk factors for long COVID or persistent symptoms those were present 12 or more weeks post-infection using multivariable regression analyses. Trial registries, reference lists of included studies, and preprint servers were hand-searched for relevant studies. Random-effects meta-analyses were conducted to pool odds ratios for each risk factor. Individual study risk of bias was rated using QUIPS, and the GRADE framework was used to assess the certainty of evidence for each unique factor.
RESULTS: Sixteen observational studies (N = 46,262) were included, and 19 risk factors were amenable to meta-analysis. With moderate certainty in the evidence, age (per 2-year increase), allergic rhinitis, obesity, previous respiratory diseases, hospitalization, severe acute COVID-19, and symptomatic acute COVID-19 are probably associated with an increased risk of long COVID. Female sex, asthma, comorbidity, and heart diseases may be associated with an increased risk of long COVID, and Asian and Black races may be associated with a decreased risk of long COVID. We did not observe any credible subgroup effects for any risk factor.
CONCLUSIONS: The current body of literature presents several compelling risk factors for the development of long COVID in the pediatric population. Further research is necessary to elucidate the pathophysiology of long COVID.
SMART MESSAGING IN MEDICAL PRACTICE COMMUNICATION Described herein are techniques and mechanisms for facilitating communications with patients of a medical practice. Patients of a medical practice may be grouped into clusters based on similar characteristics as represented in data associated with those patients. For example, patients may be clustered based on demographic data, stated communications preference data, observational data about patient behavior, clinic data characterizing a medical practice visited by the patient, and/or other such information. A default communications pattern may be determined for each cluster. The default communications pattern may include information related to communications content, channel, ordering, frequency, timing, and/or other such information for communicating with patients in the cluster. Messages may then be scheduled with patients in a cluster in accordance with the default communications pattern. Patient Smart Messaging ! Method 100 Identify patient cluster profile determination data 102 Determine two or more clusters of patients 104 Determine a default communications pattern for each cluster 106 Schedule messages in accordance with the default communications pattern 108 ( Done Figure 1
Prebiotic group will take 15 grams of prebiotic product Synergy-1 per day for 6 months. Synergy-1 is chicory-derived β-fructans inulin plus FOS (1:1). During the first two weeks the patient is advised to take 7.5 g of the product at breakfast only. Starting in week 3 until the end of the treatment the participant will take 7.5 g at breakfast and 7.5 g at dinner for a total of 6 months, or until you experience a flare.
The invention relates to an intelligent auxiliary checking device for diabetic peripheral neuropathy, which comprises a pressure air pump (1), an infrared ranging sensor (2), an intelligent evaluation module (3), a control module (4), an auxiliary handle (5), an indicator lamp (6), a power supply (7) and a switch (8). Except for the intelligent evaluation module, each unit combination is wrapped by a shell (9) of a gun type structure. The air pump is positioned at the gun barrel part of the gun type structure. The infrared distance measuring sensor is arranged below the air pump and connected with the indicator lamp. And a control module is arranged in the gun type structure and is used for receiving the output signal of the infrared ranging sensor and regulating and controlling the air flow output of the pressure air pump. The power supply is arranged at the magazine part of the gun type structure. The switch is positioned at the trigger part of the gun-type structure. The invention has the advantages that the air pump generating controllable air pressure is used for replacing the traditional 10g nylon monofilament, the detection success rate of the diabetic foot peripheral neuropathy pressure sense is improved, the structure is simple, the device can be repeatedly used, the operation is easy, the use is convenient, and the intelligent evaluation module is attached to evaluate the peripheral neuropathy degree of a patient.
The invention relates to organic-inorganic nano composite resin and a preparation method thereof, belonging to the technical field of biomedical high-molecular materials. The organic-inorganic nano composite resin is characterized in that polyfunctional reactive nano monomer, i.e. polyhedral oligosilsesquioxane (POSS) is added on the basis of organic matrixes and inorganic fillers. The preparation method comprises the steps of adding the POSS into the resin matrixes, placing in a constant-temperature oven, fully dissolving the POSS in the resin matrixes and even agitating; adding an initiator system and evenly agitating; adding the inorganic fillers which are subject to surface silanization treatment, fully and evenly agitating in a vacuum agitator and removing air bubbles to obtain nano composite resin paste. By adding the POSS into dental composite resin, polymerization shrinkage can be obviously reduced, the mechanical property of the composite resin is comprehensively improved, the micro-leakage performance and the biocompatibility are good and the application prospect in the field of oral rehabilitation is wide. Besides, the preparation process is simple, the cost is lower and the popularization value and the application value are great.
Johne's disease (JD), also known as paratuberculosis, is a chronic, untreatable gastroenteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection. Evidence for host genetic resistance to disease progression exists, although it is limited due to the extended incubation period (years) and diagnostic challenges. To overcome this, previously restored formalin-fixed paraffin embedded tissue (FFPE) DNA from archived FFPE tissue cassettes was utilized for a novel retrospective case-control genome-wide association study (GWAS) on ovine JD. Samples from known MAP-infected flocks with ante- and postmortem diagnostic data were used. Cases (N = 9) had evidence of tissue infection, compared to controls (N = 25) without evidence of tissue infection despite positive antemortem diagnostics. A genome-wide efficient mixed model analysis (GEMMA) to conduct a GWAS using restored FFPE DNA SNP results from the Illumina Ovine SNP50 Bead Chip, identified 10 SNPs reaching genome-wide significance of p < 1 × 10-6 on chromosomes 1, 3, 4, 24, and 26. Pathway analysis using PANTHER and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was completed on 45 genes found within 1 Mb of significant SNPs. Our work provides a framework for the novel use of archived FFPE tissues for animal genetic studies in complex diseases and further evidence for a genetic association in JD.
This is a controlled, randomized and blind clinical trial, which will be carried out with individuals from the city of Natal/RN, aged between 18 and 65 years, of both sexes, diagnosed with subacromial pain syndrome, who present a level of pain greater than 3 on the Numerical Pain Scale, at rest, for at least 3 months. The research sample will be non-probabilistic, in which they will be randomly distributed into two distinct groups: active tDCS (active stimulation) and sham tDCS (stimulation turned off after 20 seconds). This research was submitted to the UFRN Research Ethics Committee through the national interface Plataforma Brasil. This research covers the ethical aspects guided by Resolution 466/2012 of the National Health Council and the Declaration of Helsinki for research with human beings. In addition, the research will be registered in Clinical Trials. All data will be recorded in the laboratory's database under confidentiality and may only be processed by the responsible researchers. The study will only begin after the issuance of the reference opinion approving the project. All subjects will be duly informed and guided regarding the scheduled procedures, which will only be carried out after reading, accepting and signing the Informed Consent Form. After approval by the Research Ethics Committee, following resolution 466/2012, a pilot study was carried out to adapt all research procedures, as well as training the researchers involved. Volunteers will be duly informed about the objectives and advantages of their participation in the study, and will then undergo an assessment of pain sensation, using the Numerical Pain Scale; assessment of shoulder range of motion, using the Smartphone clinometer application; assessment of muscle strength through flexion, hyperextension, medial and lateral rotation movements of the shoulder, using a portable dynamometer; will complete the Douleur Neuropathique 4 questionnaire (DN4) to screen for neuropathic pain, the Disabilities of the arm, shoulder and hand questionnaire (DASH) to assess upper limb function, and the Short Form 36 Health Survey questionnaire (SF-36) to assess health-related quality of life. They will then undergo 20 minutes of stimulation for 5 consecutive days, according to the pre-determined group. The assessments will be repeated at the end of the intervention and in a 1-week follow-up, in which they will receive an educational booklet.
A biodegradable wound care product with biocompatible artificial skin treatment is described. It includes a biodegradable bandage support member and a biodegradable adhesive on at least a portion thereof. The support member is made of a biodegradable material, such as natural or artificial textiles, plastics or papers. The biodegradable actives carrier is attached to a portion of the biodegradable bandage support member and is a synthetic or natural biodegradable adhesive or a combination thereof. The active ingredient located on the biodegradable actives carrier includes a layer of biocompatible algae artificial skin including sterilized water and at least sixty percent by weight of reconstituted seaweed. Laminaria seaweed may be used for its desirable polyfucose sulfate content. The active ingredient is prepared by first drying the raw materials, converting the raw materials to a powder and then reconstituting the powder with sterilizes water and other possible actives and/or inerts.
PURPOSE:An agnet for vasography having low side effects, capable of adjusting osmotic pressure to a physiologically isotonic state, comprising a specific brominated perfluorocarbon, an emulsifying agent such as phospholipid of egg yolk, etc., and a specific emulsifying auxiliary. CONSTITUTION:5-100w/v% 6-7C brominated perfluorocarbon[e.g., BrCF2 (CF2)4CF2Br, etc.]containing 2 bromines atoms in the molecule is blended with 2-6w/v% emulsifying agent selected from phospholipid of egg yolk or phosholipid of soybean and/or a nonionic surface active agent of high polymer (e.g., polyoxyethylene polyoxypropylene copolymer, etc.) having a molecular weight of about 2,000-20,000 and 0.001-0.1w/v% emulsifying auxiliary consisting of 8- 22C fatty acid ester (e.g., capric acid, caprylic acid, etc.) or fatty acid salt or fatty acid monoglyceride, and the blend is adjusted to physiologically isotonic state with a highly isotonic electrolytic solution, to give an agent for vasography having particle diameters of 0.05-0.4mu. A required amount of the agent can be fed depending upon the purpose.
In active Neurofeedback session subjects will be trained to increase brain activation in regions associated with executive function (EF) function deficits (as determined by neuroimaging measures) by viewing their own brain activation in real-time. The "dose" will be 2-3 sessions, each lasting approximately 30 minutes.
An on-line self-help psychoeducational website tailored to new dads. Psychoeducational learning modules and tools, including a 6 week physical activity challenge..
Cardiovascular-kidney-metabolic (CKM) syndrome and chronic kidney disease (CKD) are two significant comorbidities affecting a large proportion of the general population with considerable crosstalk. In addition to substantial co-incidence of CKD and CKM syndrome in epidemiological studies, clinical and pre-clinical studies have identified similar pathophysiological pathways leading to both entities. Patients with CKM syndrome are more prone to develop acute kidney injury and CKD, while therapeutic alternatives and their success rates are considerably lower in such patient groups. Nevertheless, the association between CKM syndrome and CKD or ESKD is bidirectional rather than being a cause-effect relationship as patients with CKD are also prone to develop peripheral insulin resistance, high blood pressure, and dyslipidemia. Furthermore, such patients are less likely to receive kidney transplantation in addition to the higher allograft dysfunction risk. We hereby aim to evaluate the association in-between kidney diseases and CKM syndrome, including epidemiological data, pre-clinical studies with pathophysiological pathways, and potential therapeutic perspectives.
The present invention relates to a traditional Chinese medicine for treating fractures, and a preparation method thereof. After several kinds of medicines, such as angelica, chuanxiong rhizome, etc. are naturally dried, dust and impurities are removed. The medicine is processed and compounded according to a processing technique. Clinical experience and modern pharmacological action research in many years show that the traditional Chinese medicine has unique functions on modern trauma treatment and unique therapeutic effect on various kinds of osteopathy, such as various fractures, joint injury, etc. The medicine has the effect of accelerating callus growth, recovering soft tissue wounds as soon as possible, increasing the regeneration functions of periosteum and blood capillaries, controlling hematoma and inflammation, and improving the metabolic capability and the blood circulation of soft tissue. The traditional Chinese medicine comprises various requisite amino acids, bone collagen, etc. for human bodies. The traditional Chinese medicine performs the functions of invigorating the kidney and producing marrow by nourishing the liver and the kidney, and achieves the efficacy of reuniting bones and sinews by improving scleroblast activity, promoting callus generation and accelerating fracture healing. The curative rate of the present invention in clinics reaches more than 90%. The traditional Chinese medicine has the efficacy of activating blood circulation, eliminating stasis, dispersing swellings, alleviating pain and reuniting bones and sinews. The traditional Chinese medicine is suitable for the medicine treatment of various closed fractures and postoperative fractures.