anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention provides a method for manufacturing influenza HA split virus vaccine, which produces antibodies that bind to influenza HA stem region that is less prone to cause antigenic variation. The method includes a step of applying acid treatment to influenza HA split virus vaccine. The influenza HA split virus vaccine obtained by the acid treatment produces antibodies that bind to the long alpha helix (LAH) of the HA stem region. The influenza HA split virus vaccine has excellent defense against other influenza virus infections with different antigenicity. The acid treatment is carried out at pH 4.4~5.8. The influenza HA split virus vaccine is H3N2 type vaccine or H1N1 type vaccine. The present invention also provides another method for manufacturing influenza HA split virus vaccine, comprising the steps of applying acid treatment to influenza HA split virus vaccine, and implementing formalin treatment to produce antibodies that bind to the long alpha helix (LAH) of the HA stem region. The method further includes a step of mixing two or more influenza HA split virus vaccine antigens. The influenza HA split virus vaccine can be a single HA subtype influenza HA split virus vaccine. The shape of the influenza HA split virus vaccine is the influenza HA stem region exposed outside, which can improve the antigenicity of the LAH of the HA stem region and produce antibodies that bind to the LAH of the HA stem region. The method further includes a step of using an adjuvant to improve immunogenicity. Thus, according to the present invention, the influenza HA split virus vaccine can be obtained by a simple method, and the antibodies that bind to the HA stem region that influenza is not prone to cause antigenic variation can be produced, thereby obtaining the influenza HA split virus vaccine that is effective against influenza virus with antigenic variation.
The specialist nurse who is to perform IV cannulation determine the puncture site. A thick layer of cream (lidocaine and propiocaine 2.5%/2.5%) will be applied on a 1x1 cm2 area of skin on the cannulation site. The transparent dressing will be left in place for 30 minutes, then remove and clean with a sterile cotton swab. Then nurse performed IV cannulation for them.
FIELD: medicine, endocrinology. SUBSTANCE: every other day one should conduct 10 seances of acupuncture into corporal biologically active points. Additionally, during the first day of therapy one should arrange microneedles into auricular points of acupuncture. Microneedles are left intact for 21 d. Simultaneously, the intake of homeopathic preparation is prescribed. EFFECT: decreased number of side effects. 1 cl
Hwato brand disposable acupuncture needles (size 0.30 × 40 mm) and adhesive pads will be used. Acupoints of Guanyuan, Zhongwan, Tianshu, Zusanli, Taixi, Shangyintang, Taiyang, Hegu, Taichong and Shenmen will be selected. Participants will receive a total of 10-session acupuncture treatment during four weeks, three times a week in the first two weeks and twice a week in the last two weeks.
BACKGROUND: Multiple chronic conditions (MCC) are defined as the presence of two or more chronic conditions, that significantly impact health status, functional capacity, quality of life, and overall healthcare management. Despite the significant evidence on chronic disease burden, the co-existence of MCC within a household in low- and middle-income countries (LMICs) is less studied. This study therefore estimates the prevalence of MCC and its determinants among adults in the Indian households.
METHODS: Data used in this study were drawn from the fifth round of the National Family Health Survey (NFHS) conducted in 2019-21. Data sets of men (15-54 years) and women (15-49 years) were used for the study. The total sample size of adults for this analysis was N = 239,848. The outcome variable of this study was multiple chronic conditions (MCC) in adults which included a total of nine chronic conditions (hypertension, diabetes, chronic respiratory diseases, chronic kidney disorders, cancer, thyroid disorders, obesity, and heart diseases, consuming alcohol, chewing tobacco, and smoking) documented in NFHS-5. Descriptive statistics and binary logistic regression analysis were used to quantify the results.
RESULTS: A prevalence of 5.5% of MCC in adults emerged from our study. Logistic regression analysis identified that younger age, males (AOR 0.36 (0.33-0.39)), urban areas (AOR 1.11 (1.02-1.17)) as the place of residence, and participants representing SC (AOR 0.89 (0.81-0.97)), and ST (AOR 1.30 (1.17-1.45)), had a higher risk of MCC irrespective of level of education, type of occupation, marital status, or wealth index, and states from any category of social progress.
CONCLUSION: A 5% prevalence of MCC specifically obesity, substance use, and hypertension calls for integrated efforts aiming at behavior change, and regulatory efforts to prevent further increase of MCC among young adults in India.
Premature infants are at risk for complications due to the immaturity of motor, gastrointestinal, respiratory, cutaneous and behavioral systems. Therapeutic positioning is routinely used to provide containment, maintain a flexed position and prevent skeletal deformities and delays in motor development. Premature infants have feeding difficulties and frequently experience gastroesophageal reflux, discomfort, refusal to feed, irritability, and crying. The neonatal intensive care environment can create stress and disrupts sleep-wake cycles and self-regulatory behaviors. Cycling from active to deep sleep states is required for neurosensory processing, learning, memory formation and brain plasticity. Sleep and waking states for premature infants are predictive of neurodevelopmental outcomes. The purpose of the study is to determine whether the use of conformational positioning will be associated with greater total sleep time in premature infants with a history feeding difficulty compared to positioning on a mattress alone. We hypothesize that the number of arousals and total sleep time will be affected by the support surface. Specifically, the number of arousals will be lower and total sleep time will be greater for infants when they are on a conformational positioning (CP) device compared to when they are on the standard positioning system (mattress) (SP). The use of CP will reduce the number of arousals, increase the total sleep time, and bring about behavioral states that are conducive to regulation of attention, state and motor response relative to SP.
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modu-lation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucle-otides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units suffi-cient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specif-ically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated se-quences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are dis-closed.
The prospective phase will enroll patients planning to undergo TAVR, at the discretion of Drs. Wan and Fatemi, and if they meet all of the inclusion criteria and none of the exclusion criteria. All patients who provide consent will undergo the TAVR procedure where the valve will be double inflated. Echocardiogram results and procedure details will be collected as data. At the patient's 30-day follow-up clinic visit, as per standard of care, they will be re-evaluated with an echocardiogram. Details from that follow-up visit and the echocardiogram results will be collected as data. Prospective enrollment will begin upon IRB approval and we plan to continue enrollment until December 31, 2023, or once 200 participants are reached, whichever comes first.
RATIONALE: Patient-centred care has emerged as a transformative approach in managing chronic diseases, aiming to actively involve patients in their healthcare decisions.
AIMS AND OBJECTIVES: This study was conducted to analyse and map the research landscape on patient-centred care in the context of chronic disease management.
METHODS: This study used Scopus to retrieve the relevant articles. The analysis focused on the growth pattern, highly cited articles, randomised clinical trials, patients and providers perspectives, facilitators and barriers, frequent author keywords, emerging topics, and prolific countries and journals in the field.
RESULTS: In total, 926 research articles met the inclusion criteria. There was a notable increase in the number of publications over time. Cancer had the highest number of articles (n = 379, 40.9%), followed by diabetes mellitus, and mental health and psychiatric conditions. Studies on patient-centred care in diabetic patients received the highest number of citations. The results identified 52 randomised controlled trials that covered four major themes: patient-centred care for diabetes management, shared decision-making in mental health and primary care, shared decision-making in cancer care, and economic evaluation and cost-effectiveness. The study identified 51 studies that examined the impact of tools such as computer-based systems, decision aids, smartphone apps, and online tools to improve patient-centred outcomes. A map of author keywords showed that renal dialysis, HIV, and atrial fibrillation were the most recent topics in the field. Researchers from the United States contributed to more than half of the retrieved publications. The top active journals included "Patient Education and Counselling" and "Health Expectations".
CONCLUSION: This study provides valuable insights into the research landscape of patient-centred care within the context of chronic diseases. The current study provided a comprehensive overview of the research landscape on patient-centred care, which can empower patients by raising their awareness about clinical experiences and outcomes.
Liver fibrosis and cirrhosis, which are caused by chronic liver injury, represent common and intractable clinical challenges of global importance. However, effective therapeutics are lacking. Therefore, the study examines the effect of doxazosin on liver fibrosis. Carbon tetrachloride (CCl4) is injected into mice to establish a liver fibrosis model. Doxazosin (5 and 10 mg/kg) is administered daily by gavage. HE staining, Masson staining, Sirius Red staining, scanning electron microscopy, western blotting, real-time PCR, and immunofluorescence analysis are performed to estimate liver fibrosis and sinusoidal capillarization in mice. Cell Counting Kit-8 assays, western blotting, immunofluorescence analysis, tube formation, and transwell migration assays are performed on human umbilical vein endothelial cells (HUVECs) and human hepatic sinusoidal endothelial cells (HHSECs) to elucidate the potential mechanism of doxazosin. Doxazosin alleviates liver fibrosis and sinusoidal capillarization in CCl4-induced mice. Angiogenesis is attenuated by doxazosin in HUVECs and HHSECs. This study demonstrates that doxazosin attenuated liver fibrosis by alleviating sinusoidal capillarization and liver angiogenesis.
CBT preference arm consists of participants who are randomized to the preference condition and choose to receive cognitive-behavioral therapy (CBT). CBT consists of 10 weeks of weekly treatment.
BACKGROUND: Zinc finger protein 1 (ZPR1), encoded by the ZNF259 gene, plays crucial roles in transcriptional regulation and cell cycle progression. Despite its known functions, its specific involvement in Metabolic Syndrome (MetS) remains debated. Genome-wide association studies have identified several genes, including ZNF259, implicated in lipid metabolism and associated with MetS. Single nucleotide polymorphisms (SNPs) in ZNF259 have been linked to altered lipid metabolism during the development of MetS. This study aims to investigate the association between MetS in Egyptian patients and three specific ZNF259 SNPs: rs964184, rs2075294, and rs2075290. The objective is to explore how these SNPs correlate with MetS development, other health outcomes, and their interaction with dyslipidemia biomarkers.
METHODS: 200 Egyptian participants were enrolled, and divided into two groups: 100 patients diagnosed with dyslipidemia and 100 healthy controls. The study involved comprehensive assessments, including lipid profile analysis, anthropometric measurements, and genotyping of rs964184, rs2075290, and rs2075294 in the ZNF259 gene using Real-Time Polymerase Chain Reaction (PCR).
RESULTS: The findings indicate that rs964184 SNP correlates significantly with elevated plasma triacylglycerol (TG) levels, while rs2075290 and rs2075294 are associated with higher total serum cholesterol (TC) and TG levels. Among these SNPs, rs2075294 showed the highest predictive value (area under the curve of 0.748), followed by rs2075290 (0.738), and rs964184 (0.583), suggesting rs2075294 as the most influential SNP in MetS prediction.
CONCLUSION: This study underscores the predictive role of ZNF259 SNPs in MetS risk among Egyptians. Future research should further explore the implications of ZNF259 in MetS pathogenesis and its potential as a biomarker for personalized health interventions.
Participants are asked to think and write about all that they have done the last 24 hours. They carry out the exercise in a powerpoint document, where they can record all the activities, situations and thoughts occurred in the past 24 hours.
FIELD: medicine, urgent cardiology. SUBSTANCE: invention relates to prophylaxis and treatment of patients with cardiac insufficiency after infarct. Method involves carrying out the conventional treatment of infarct and cardiac insufficiency in combination with additional administration of interkeukin-2 in the dose 200 000-500 000 IU, twice, in 48 h after infusion. Method provides lasting effect under providing conditions of angiogenesis stimulation. EFFECT: improved method of prophylaxis and treatment. 2 ex
Research on culturally sensitive assessment and treatment of eating disorders among Latinos is scarce. This study is comparing individual Cognitive Behavioral Therapy (CBT) versus CBT with a family adjunctive intervention for eating disorders in Latina adults. All treatment will be conducted by trained professionals from either the UNC Eating Disorders Program (in Chapel Hill) or from El Futuro, Inc. (in Carrboro or Durham, NC) who have been trained in the treatment of eating disorders.

Participants will participate in 25, 50 minute-long, face-to-face CBT sessions over 27 weeks. Participants will be randomly placed in one of two groups: CBT or CBT with family enhancement. Those participants who are randomly placed into the CBT group will participate in 25 individual therapy sessions, 3 sessions with a dietitian, and psychiatry and/or medical assessments as needed. Those participants who have been randomly placed into the CBT with family enhancement group will participate in 19 individual therapy sessions, 6 family therapy sessions, 3 sessions with a dietitian, and psychiatry and/or medical assessments as needed. All participants will also be expected to participate in baseline, week 6 (mid-treatment), end of treatment, and 3-month follow-up assessments.
PURPOSE:To provide a pack agent containing a low mol.wt. furfural polymer and suitable for cleansing face surfaces and beautifying skins. CONSTITUTION:A pack agent contains (A) a liquid material containing a low mol.wt. furfural polymer produced by reacting furfural with a caustic alkali and water, preferably by mixing the mixture of furfural with a caustic alkali in an amount of 10-50 pts.wt. per 100 pts.wt. of the furfural and the water preliminarily heated to >=75 deg.C, and subsequently holding the mixture in a boiling state for 10-40min, and (B) starch, preferably wheat flour, especially soft flour containing a small amount of protein. The content of the starch is 30-70wt.%, preferably 35-60wt.%, based on the whole amount of the pack agent. The pack agent is preferably used together with a water-holding agent, humectant or moistening agent in an amount of 15-35 pts.wt. per 100 pts.wt. of the starch.
Participants performing a rehabilitation program for 5 times a week in a total of 4 weeks in one of two rehabilitation centers in Trondheim, Norway. The aim is to perform a total of 20 maximal strength training interventions supervised by one or more health professionals. Maximal strength training will be performed with 4 repetitions and 4 series at 90-95% of one repetition maximum.
<P>PROBLEM TO BE SOLVED: To provide a recalcification promoter for dental caries prevention and to use the recalcification promoter so as to promote tooth recalcification, to prevent excessive tooth decalcification and to prevent dental caries.  <P>SOLUTION: The recalcification promoter contains lactobionic acid. The food and beverage contains the recalcification promoter. The amount of the recalcification promoter is 0.01-100 mass%, preferably 0.05-50 mass%, more preferably 0.1-20 mass% based on the total mass of the food and beverage. The beverage may be a beverage such as tea, fruit-vegetable-based beverage, alcoholic beverage, carbonated beverage, lactic acid bacteria beverage, milk beverage, soft drink, low-calorie beverage, etc., and the food may be a perishable food or processed food, preferably a chewing gum kept in the oral cavity for a fixed time, candy, caramel, gummy jelly, etc.  <P>COPYRIGHT: (C)2010,JPO&INPIT
FIELD: medicine, phthisiology. SUBSTANCE: method of indication of tuberculosis mycobacteria in air medium involves passing air sample through electric field. Bacteria are charged in the zone of negative charge and precipitated on positively charged electrode made as a changeable metallic tray covered with liquid nutrient medium for culturing tuberculosis mycobacteria. The latter are cultured for 2 days, concentrated and supernatant is removed. Obtained precipitate is resuspended and tuberculosis mycobacteria are identified by molecular-genetic method using polymerase chain reaction. Method ensures to detect tuberculosis mycobacteria in air for short time (3-5 days). Method provides to reveal minimal concentrations of tuberculosis mycobacteria that are impossible to detect by methods of bacterioscopy and cultural diagnosis. EFFECT: improved method of indication. 3 cl, 2 tbl
The present invention addresses the problem of providing a novel transparent cleansing agent showing excellent stability over time in spite of containing water, while having high cleansing power. A transparent cleansing agent that solves the problem of the present invention is characterized by being a water-containing reverse micelle type containing the following components (A) to (F). (A) An ester of a fatty acid having 8-10 carbon atoms with polyglycerol. (B) An ester of a branched fatty acid and/or an unsaturated fatty acid having 14-22 carbon atoms with polyglycerol. (C) An aliphatic alcohol and/or a fatty acid being in the liquid state at 25℃. (D) An oil containing a hydrocarbon oil (except component (C)). (E) More than 0 mass% and not more than 10 mass% of water. (F) A polyhydric alcohol.
This arm will consume 2 portions of gilthead seabream fed with conventional diet. Each portion weighed on average 380 g (raw, quantity of edible fillet approximately 170 g). Participants were instructed to consume fish twice weekly, one portion at a time.
A cohort of adolescents ages 11 to 14 who received 1 dose of the HPV vaccine from January 2017 to December 2017 within the university's health system network. The cohort was followed from January 2018 to February 2019 to assess vaccine completion within a 14-month period.
Exposure to mercury has been associated with adverse effects on pregnancy outcomes. However, there is limited literature on mercury exposure and pregnancy outcomes in Chinese pregnant women. Our study was to investigate the possible association between maternal mercury exposure and spontaneous preterm birth and birth weight. This study was a nested case-control study. The association between blood mercury concentration and both spontaneous preterm birth and birth weight was analyzed using conditional logistic regression and linear regression adjusted for the potential confounding factors, respectively. The dose-response relationship between mercury concentration and birth outcomes was estimated using restricted cubic spline regression. The mean concentration of mercury was 2.8 ± 2.2 µg/L. A positive relationship was observed between maternal blood mercury concentration and SPB when analyzed as a continuous variable. However, it was not found to be statistically significant (adjusted OR = 1.10, 95% CI = 0.95-1.26, P = 0.202). Moderate mercury exposure was associated with a higher risk of SPB (Q3 vs. Q1: crude OR = 2.50, 95% CI = 1.16-5.41, P = 0.02; adjusted OR = 3.49, 95% CI = 1.33-9.11, P = 0.011). After considering the combined effects of chemicals other than mercury exposure (including lead, selenium, and cadmium), the results remained consistent. There was no statistically significant association between blood mercury levels and birth weight (adjusted coefficient = 18.64, P-value = 0.075). There were no statistically significant dose-response associations between mercury concentration and birth outcomes (SPB: P = 0.076; birth weight: P = 0.885). Public health policies should focus on reducing environmental releases of mercury, improving food safety standards, and providing education to pregnant women about the risks of mercury exposure and preventive measures.
There have been postmarketing reports of serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) in patients treated with tirzepatide. In a pool of two ZEPBOUND clinical trials (Studies 1 and 2), 0.1% of ZEPBOUND-treated patients had severe hypersensitivity reactions compared to no placebo-treated patients. If hypersensitivity reactions occur, advise patients to promptly seek medical attention and discontinue use of ZEPBOUND. Do not use in patients with a previous serious hypersensitivity reaction to tirzepatide or any of the excipients in ZEPBOUND [see Contraindications (4) and Adverse Reactions (6.2)]. 

Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with GLP-1 receptor agonists. Use caution in patients with a history of angioedema or anaphylaxis with a GLP-1 receptor agonist because it is unknown whether such patients will be predisposed to these reactions with ZEPBOUND.
The distal portion of the GOO tailored stents was semi-spherical, with a length of 20 mm, and a diameter of 28 mm. The middle segment had a diameter of 20 mm. The overall length of the stents was 100 mm. Both the middle part and the bottom of the proximal cup segment, and a part of the proximal funnel segment, were covered by a polyethylene membrane.