anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Gynecologic cancers cause substantial morbidity and mortality among women. Developing, implementing, and disseminating interventions that reduce morbidity and mortality secondary to gynecologic cancers are a public health priority. To the extent that psychological factors may influence quality of life and tumor biology among women with gynecologic cancers, psychological interventions may represent an important adjunct to standard clinical care in this population. Among individuals with cancer, there is emerging evidence that stressors and psychological responses to stressors activate central and peripheral stress systems, resulting in downstream effects on the tumor microenvironment, e.g. hypothalamic-pituitary-adrenal (HPA) axis dysregulation, inflammatory/growth factor upregulation that may favor tumorigenesis. Little is known about whether psychological interventions may modulate biobehavioral factors that may promote tumorigenesis among women with gynecologic cancer. This is a significant gap in the literature. Sleep quality, pain, and mood are three patient-centered outcomes that may represent important intervention targets for women with gynecologic cancers, as insomnia, pain, and negative mood states are (1) prevalent and (2) have been associated with HPA dysregulation and inflammatory/growth factor upregulation in this population in empirical research. This study will examine cognitive behavioral therapy (CBT) intervention effects on patient centered and physiological outcomes among women with gynecologic cancers undergoing adjuvant chemotherapy. Grounded within the Central Arousal Theory of Stress (CATS) and a biobehavioral model of tumor biology, the central hypothesis is that a CBT intervention targeting insomnia and pain will (a) improve nighttime sleep patterns, pain, and negative mood states, and (b) reduce cortisol levels, normalize daytime cortisol rhythm, and reduce proinflammatory/proangiogenic cytokine levels in women with gynecologic cancers. The multidisciplinary team will have research/clinical experience in psycho-oncology, psychoneuroimmunology (PNI), behavioral sleep medicine, pain, reproductive immunology, and gynecologic oncology. The research study is innovative in that it will (1) combine empirically-supported CBT techniques for insomnia and pain into a multicomponent intervention tailored for women with gynecologic cancers, and (2) examine CBT effects on central sensitization of pain among individuals with cancer using quantitative sensory testing (QST). The results of this research will be significant to public health initiatives, because although gynecologic cancers are among the leading causes of cancer-related death among women, there is a paucity of research examining the effects of psychosocial interventions on patient-centered and physiological outcomes in this population.
BACKGROUND: The incidence of male reproductive dysfunction is increasing annually, and many studies have shown that obesity can cause severe harm to male reproductive function. The mechanism of male reproductive dysfunction caused by obesity is unclear, and there is no ideal treatment. Identification of effective therapeutic drugs and elucidation of the molecular mechanism involved in male reproductive health are meaningful. In this study, we investigated the effects of the GLP-1 receptor agonist liraglutide on sex hormones, semen quality, and testicular AC3/cAMP/PKA levels in high-fat-diet-induced obese mice.
METHODS: Obese mice and their lean littermates were treated with liraglutide or saline for 12 weeks. Body weight was measured weekly. Fasting blood glucose (FBG) was measured using a blood glucose test strip. The serum levels of insulin (INS), luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), free testosterone (F-TESTO), estradiol (E2), and sex hormone binding globulin (SHBG) were detected using ELISA. The sperm morphology and sperm count were observed after Pap staining. The mRNA and protein expression levels of testicular GLP-1R and AC3 were measured by RT-qPCR and Western blot, respectively. Testicular cAMP levels and PKA activity were detected using ELISA.
RESULTS: Liraglutide treatment can decrease body weight, FBG, INS, HOMA-IR, E2 and SHBG levels; increase LH, FSH, T, and F-TESTO levels; increase sperm count; decrease the sperm abnormality rate; and increase GLP-1R and AC3 expression levels and cAMP levels and PKA activity in testicular tissue.
CONCLUSIONS: Liraglutide can improve the sex hormone levels and semen quality of obese male mice. In addition to its weight loss effect, liraglutide can improve the reproductive function of obese male mice, which may also be related to the upregulation of AC3/cAMP/PKA pathway in the testis. This work lays the groundwork for future clinical studies.
In recent years, the environmental health issue of microplastics has aroused an increasingly significant concern. Some studies suggested that exposure to polystyrene microplastics (PS-MPs) may lead to renal inflammation and oxidative stress in animals. However, little is known about the essential effects of PS-MPs with high-fat diet (HFD) on renal development and microenvironment. In this study, we provided the single-cell transcriptomic landscape of the kidney microenvironment induced by PS-MPs and HFD in mouse models by unbiased single-cell RNA sequencing (scRNA-seq). The kidney injury cell atlases in mice were evaluated after continued PS-MPs exposure, or HFD treated for 35 days. Results showed that PS-MPs plus HFD treatment aggravated the kidney injury and profibrotic microenvironment, reshaping mouse kidney cellular components. First, we found that PS-MPs plus HFD treatment acted on extracellular matrix organization of renal epithelial cells, specifically the proximal and distal convoluted tubule cells, to inhibit renal development and induce ROS-driven carcinogenesis. Second, PS-MPs plus HFD treatment induced activated PI3K-Akt, MAPK, and IL-17 signaling pathways in endothelial cells. Besides, PS-MPs plus HFD treatment markedly increased the proportions of CD8+ effector T cells and proliferating T cells. Notably, mononuclear phagocytes exhibited substantial remodeling and enriched in oxidative phosphorylation and chemical carcinogenesis pathways after PS-MPs plus HFD treatment, typified by alterations tissue-resident M2-like PF4+ macrophages. Multispectral immunofluorescence and immunohistochemistry identified PF4+ macrophages in clear cell renal cell carcinoma (ccRCC) and adjacent normal tissues, indicating that activate PF4+ macrophages might regulate the profibrotic and pro-tumorigenic microenvironment after renal injury. In conclusion, this study first systematically revealed molecular variation of renal cells and immune cells in mice kidney microenvironment induced by PS-MPs and HFD with the scRNA-seq approach, which provided a molecular basis for decoding the effects of PS-MPs on genitourinary injury and understanding their potential profibrotic and carcinogenesis in mammals.
Patients undergo SBRT with watchful waiting. Cycles repeat every 4 months (16 weeks) in the absence of disease progression or unacceptable toxicity.
In a 2-year oral carcinogenicity study in rats, abrocitinib increased the incidence of benign thymomas in female rats at doses of 10 and 30 mg/kg/day (2.8 and 14 times the MRHD, respectively, based on AUC comparison). Abrocitinib was not carcinogenic in female rats at 3 mg/kg/day (0.6 times the MRHD based on AUC comparison) or male rats at doses up to 30 mg/kg/day (14 times the MRHD based on AUC comparison). Abrocitinib was not carcinogenic in Tg.rasH2 mice at oral doses up to 60 mg/kg/day in males and 75 mg/kg/day in females.

Abrocitinib was not mutagenic in the bacterial mutagenicity assay (Ames assay). Although abrocitinib was aneugenic in the in vitro TK6 micronucleus assay, abrocitinib was not aneugenic or clastogenic in an in vivo rat bone marrow micronucleus assay.

Abrocitinib did not impair male fertility at doses up to 70 mg/kg/day (26 times the MRHD based on AUC comparison) or female fertility at 10 mg/kg/day (2 times the MRHD based on AUC comparison). Abrocitinib impaired female fertility (reducing fertility index, corpora lutea, and implantation sites) at 70 mg/kg/day (29 times the MRHD based on AUC comparison). Impaired fertility in female rats reversed 1 month after cessation of abrocitinib administration.
Education and counseling as usually delivered in clinical practice. 100 pairs (200 subjects) are randomized to this arm.
Once weekly sessions of balance training for 3 or 6 weeks. Each session will be 20 minutes of training. Training will involve standing balance under varied sensory conditions, and tandem walking forward and backward under varied sensory conditions.
A composition for use in hairdressing comprises an aqueous solution of a polymeric N-vinyl lactam and a water-soluble plasticizer having a pH of 6.5 to 11.  The lactam may be a polymer of 1-vinyl-2-pyrrolidone, 1-vinyl-5-methyl - 2 - pyrrolidone, 1 - vinyl - 2 - piperidone, or cyclic -N-vinyl-e -caprolactam. Plasticizers mentioned are ethylene, diethylene, propylene, trimethylene, tetramethylene, hexamethylene and polyethylene glycols, dimethoxy tetraglycol, glycerol, glycerol monoacetate, pentaerythritol monoacetate, and sorbitol.  The compositions may also contain borax, ethyl alcohol, pH adjusters such as alkali metal carbonates, amines, or alkylated ammonium salts, gloss promotors, e.g. the polyoxyethylene monoester of tall oil, polyoxyethylene ethers of long chain alcohols, alkylated phenols, or polyoxyethylene glycol, brightening compounds such as 4:41-ditriazyldiaminostilbene-2,21-disulphonic acid, and perfumes. The compositions may be used for waving and setting hair.ALSO:A hair waving composition comprises an aqueous solution of a polymeric N-vinyl lactam and a water-soluble plasticizer having a pH of 6.5 to 11.  The lactam may be a polymer of 1-vinyl-2-pyrrolidone, 1-vinyl-5-methyl-2-pyrrolidone, 1-vinyl-2-piperidone, or cyclic-N-vinyl-e -caprolactam. Plasticizens mentioned are ethylene, diethylene, propylene, trimethylene, tetramethylene, hexamethylene, and polyethylene glycols, dimethoxy tetraglycol, glycerol, glycerol monoacetate, pentaerythritol monoacetate and sorbitol.  The compositions may also contain borax, ethyl alcohol, pH adjustors such as alkali metal carbonates, amines, or alkylated ammonium salts, gloss promotors such as the polyoxyethylene monoester of tall oil, polyoxyethylene ethers of long chain alcohols, alkylated phenols or polyoxyethylene glycol, brightening compounds such as 4, 41-ditriazyl-diaminostilbene -2, 21-disulphonic acid, and perfumes. The composition may be applied by spraying or dipping a comb in the solution and the hair sets on drying.  The treated hair may be wetted and re-set.
This invention discloses method of producing Chinese caterpillar fungus SOD. It includes chalk in, dipping, crushing and filtrating, ultrafiltrating concentrating deposition and precipitation, dilution and freeze dry. There are several advantages in producing SOD by this method: the technique is simple, operation is convenient, asepsis and innocuity, its safety is high and cost is low. So the SOD has strong anti fatigue effect, refection and tranquilization, especially good effect to sober up and liver injury protection. The SOD health products provided by the invention has specially good effect to kidney invigorating by its oral administration capsule, food and wine, it has strong anti fatigue effect, refection and tranquilization, especially good effect to sober up and liver injury protection. It can slacken senescence by using with soybean isoflavone, and it also has good hairdressing effect. The weight reduction effect can be done by synchronously using with gamboges extract, if it is added into exterior cosmetic, the goal of fight against senium can be gained.
Reaction products of cationic and anionic surface-active agents are prepared by reacting a cationic surface-active base which has one or more functionally basic groups containing sulphur or quaternary or non-quaternary nitrogen and an anion-active acid which is a fatty acid, an acid sulphate of a fatty alcohol or an alkylaryl sulphonic acid.  Suitable cationactive substances are those sold under the registered Trade Marks "Sapamin," "Soromin" and "Velan".  In examples: (1) a waxy product is prepared by heating dioxydiethylenetriamine distearylamide with distearic acid; (2) lauryldimethylsulphonium oleate is prepared by reacting sodium oleate with lauryldimethylsulphonium methosulphate; (3) oleic acid and diethylethylene diamine-oleylamide are reacted together.  The products are used as ingredients of hair-treating compositions (see Group IV (c)). Specifications 316,090, 328,675, [both in Class 2 (iii)], 358,202 and 442,466 are referred to.ALSO:A hair-treating composition in the form of a cream is characterized in that it contains in association with a hair dye or permanent waving agent a product obtained by reacting a cationic surface-active base which has one or more functionally basic groups containing sulphur or quaternary or non-quarternary nitrogen and an anionactive acid which is a fatty acid, an acid sulphate of a fatty alcohol or an alkylaryl sulphonic acid.  The reaction products can be prepared by dissolving the reactants together or by double decomposition or by quaternization of the cation-active group after the formation of a salt with the anionactive acid.  The products maintain, in dispersion, hair dyes and permanet waving agents such am ammonium thioglycollate. When used in hair-dyeing, the excess cream can be removed by shampooing.  Suitable cation-active substances are, e.g., those sold under the Registered Trade Marks, "Sapamin", "Soromin" and "Velan", which may be used as their hydrochloric, acetic or methyl sulphonic acid salts.  The compositions can contain as solvents alcohols, glycols, glycol ethers and esters, sorbital, glycerine and formamide.  Hair dye liquids obtained can be transformed into a cream on adding water or aqueous solutions, e.g., of hydrogen peroxide.  In examples (1) a cream for permanent waving is prepared by forming a waxy reaction product from dioxydiethylene - triamine - distearylamide and stearic acid, heating with borax, sorbitol and water, and when the mixture is homogeneous cooling to 30 DEG C. and adding ammonium thioglycolate and ammonia; (2) a hair dye is obtained by mixing a solution in isopropyl alcohol of a waxy product obtained as in (1) with a solution of hair dye and hydrogen peroxide to give a creamy preparation.  As an alternative, there may be used lauryldimethyl-sulphonium oleate obtained by reacting sodium oleate and lauryldimethylsulphonium methosulphate; (3) a reaction product of equi-molecular amounts of oleic acid and diethyl-ethylenediamine oleylamide is dissolved in isopropyl alcohol and mixed with commercial hair dye solutions containing soaps.  Specifications 316,090, 328,675, [both in Class 2(iii)], 358,202 and 442,466 are referred to.
Approximately 20% of college students are regular marijuana users, and are at risk for cognitive and academic problems, addiction, and risk behaviors such as driving while impaired. Young adult marijuana users are thus a high-risk population and may require an intervention that motivates marijuana reductions by increasing engagement in constructive alternatives to marijuana use. Brief Motivational Interventions (BMIS) have demonstrated efficacy for alcohol use in college students, but lack consistent evidence of efficacy for marijuana use. This research team has developed a supplement to alcohol BMIs, the Substance-Free Activity Session (SFAS), which directly targets the behavioral economic mechanisms of both substance-free reinforcement and delayed reward discounting by encouraging the development of and commitment to academic and career goals, and by highlighting the impact of day-to-day patterns of alcohol use and academic engagement on these goals. A controlled pilot trial found that the SFAS improved BMI outcomes in a sample of heavy drinking college students, and the ongoing parent trial to this revision is replicating and extending those results. This study will evaluate the SFAS using a randomized 3-group (BMI + SFAS vs. BMI + Relaxation Attention Control, vs. Assessment Only) pilot trial with 120 undergraduates (50% female, 40% minority) who report using marijuana on \> 5 days in the past-month. It is hypothesized that at the 1-month and the next-semester follow-ups (follow-ups are wedded to the academic calendar to allow for representative measurement of marijuana use and activity patterns) BMI+SFAS participants will report significantly lower levels of marijuana use and problems, and that these reductions will exceed those of BMI + Relaxation and Assessment-Only participants. Exploratory analyses will test the hypotheses that (a) the BMI + SFAS will be more effective for participants who report higher baseline marijuana reinforcing efficacy and delayed reward discounting; and (b) the advantage of BMI + SFAS on marijuana use will be mediated by increased participation in substance-free activities. Support for our hypotheses would extend behavioral economic theory and would provide initial validation for an approach that could be used to reduce marijuana misuse among the increasing population of college students who misuse marijuana. Furthermore, given the focus of the SFAS is to increase academic/campus engagement, this work has the potential for widespread dissemination.
Since XENAZINE or its metabolites bind to melanin-containing tissues, it could accumulate in these tissues over time. This raises the possibility that XENAZINE may cause toxicity in these tissues after extended use. Neither ophthalmologic nor microscopic examination of the eye has been conducted in the chronic toxicity studies in a pigmented species, such as dogs. Ophthalmologic monitoring in humans was inadequate to exclude the possibility of injury occurring after long-term exposure.

The clinical relevance of XENAZINE’s binding to melanin-containing tissues is unknown. Although there are no specific recommendations for periodic ophthalmologic monitoring, prescribers should be aware of the possibility of long-term ophthalmologic effects [see Clinical Pharmacology (12.2)].
Krüppel-like factor 12 (KLF12) has been characterized as a transcriptional repressor, and previous studies have unveiled its roles in angiogenesis, neural tube defect, and natural killer (NK) cell proliferation. However, the contribution of KLF12 to cancer treatment remains undefined. Here, we show that KLF12 is downregulated in various cancer types, and KLF12 downregulation promotes cisplatin resistance and cancer metastasis in esophageal squamous cell carcinoma (ESCC). Mechanistically, KLF12 binds to the promoters of L1 Cell Adhesion Molecule (L1CAM) and represses its expression. Depletion of L1CAM abrogates cisplatin resistance and cancer metastasis caused by KLF12 loss. Moreover, the E3 ubiquitin ligase tripartite motif-containing 27 (TRIM27) binds to the N-terminal region of KLF12 and ubiquitinates KLF12 at K326 via K33-linked polyubiquitination. Notably, TRIM27 depletion enhances the transcriptional activity of KLF12 and consequently inhibits L1CAM expression. Overall, our study elucidated a novel regulatory mechanism involving TRIM27, KLF12 and L1CAM, which plays a substantial role in cisplatin resistance and cancer metastasis in ESCC. Targeting these genes could be a promising approach for ESCC treatment.
The invention relates to hair dye for enhancing color fastness of natural pigment curcumin. The natural pigment curcumin comprises agent A and agent B, wherein the agent A comprises the curcumin, and the agent B comprises rare-earth metal mordant. The agent A comprises, by weight, 0.1% to 10% of the curcumin, 1% to 10% of surfactant, 1% to 5% of hydroxymethyl propyl cellulose, and the balance water, and the pH (potential of hydrogen) value of the agent A is adjusted to 3-7. The agent B comprises, by weight, 1% to 5% of the rare-earth metal mordant, 1% to 5% of hydroxymethyl propyl cellulose, 1% to 10% of surfactant, 0.1% to 0.3% of natural essence, and the balance water, and the pH value of the agent B is adjusted to 3-7. The rare-earth metal mordant comprises rare-earth metal neodymium ion salt which is allowable to cosmetics, comprises but not limited to neodymium nitrate, neodymium sulfate and neodymium chloride. The hair dye for enhancing color fastness of natural pigment curcumin is simple to process, easy to operate, long in coloration effect duration time, strong in fastness to washing, green and environment-friendly.
FIELD: medicine.SUBSTANCE: invention relates to radiation diagnostics, medical parasitology and infectious diseases, and can be used for rapid determination of hepatic alveococcosis activity by ultrasonic analysis with echo contrast. Method includes ehocontrast substance in dose of 2.5 ml into a central vein with subsequent introduction of 10 ml of normal saline. Examination is started at the moment of introducing normal saline and is performed for a time sufficient for recording the arterial and venous phases. Presence of accumulation of echoes in formation, which is a parasitic node, contrasting of a peri-parasitic infiltrate, vessels feeding into a parasitic node is evaluated. If the echonastic substance does not accumulate in the structure of the formation, the peri-parasitic infiltrate is contrasted, the vessels feeding into the parasitic node are not detected, the inactive alveococcus is determined. If the echonastic substance does not accumulate in the structure of the formation, the periparasitic zone is not contrasted, the vessels delivering the parasitic node are determined, the active form of alveococcus is determined.EFFECT: method provides a non-invasive rapid determination of the activity of alveococcal liver involvement by ultrasonic examination with echo contrast, start of echocontrasting at the moment of introduction of physiologic saline and its carrying out during arterial and venous phases.1 cl, 2 ex
Infections of toe nails and finger nails caused by fungi and yeast are treated topically by applying a liquid mixture of natural ingredients to the infected area. The mixture includes the essential oils of between about 10 and about 17 ml. of tea tree; between about 10 and about 17 ml. of lavender oil, and between about 1 and about 3.5 ml. of eucalyptus oil in a total of 30 ml. of liquid. All of the ingredients preferably are pharmaceutical grade for the best results. The liquid mixture is typically applied to the affected area once or twice a day for a period of at least two months until the infection is cured. A few drops of the composition can also be placed into the toe box of shoes and the toe portion of slippers when not being worn to prevent re-infection.