anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The investigators will recruit approximately 3350 African-American or Caucasian adult males with a high-school diploma or less. A pilot study, which ran during the 2019-20 flu season, recruited approximately 850 subjects, and a planned scale-up will recruit an additional 2500 subjects during the 2020-21 flu season. The investigators will oversample African American individuals, emphasizing low-income and minority men because these characteristics are correlated with lower relative take-up of flu vaccination. After informed consent is obtained, subjects will be asked about sociodemographic information (age, education, income and marital status), healthcare experience and past medical history, knowledge and beliefs about flu vaccination, and location of the nearest pharmacy. The investigators will then randomly assign the adult male subjects to videos which contain one of Black or white actors playing the role of either a doctor or a layperson as well as different scripts. The content of the infomercial will be the safety and effectiveness of adult seasonal flu vaccination. After the video, the investigators will obtain information on beliefs regarding vaccination, feedback on the video, attention to the video and willingness-to-pay for a flu shot coupon. The final baseline module will consist of a randomly assigned invitation to receive the results of an upcoming review of a COVID-19 vaccine, with subjects assigned to receive information from a trusted or standard source. The investigators will track flu coupon redemption, which is redeemable at most pharmacies nationwide.
This study aims to develop an MRI-based radiomics model to assess the likelihood of recurrence in luminal B breast cancer. The study analyzed medical images and clinical data from 244 patients with luminal B breast cancer. Of 244 patients, 35 had experienced recurrence and 209 had not. The patients were randomly divided into the training set (51.5 ± 12.5 years old; n = 171) and the test set (51.7 ± 11.3 years old; n = 73) in a ratio of 7:3. The study employed univariate and multivariate Cox regression along with the least absolute shrinkage and selection operator (LASSO) regression methods to select radiomics features and calculate a risk score. A combined model was constructed by integrating the risk score with the clinical and pathological characteristics. The study identified two radiomics features (GLSZM and GLRLM) from DCE-MRI that were used to calculate a risk score. The AUCs were 0.860 and 0.868 in the training set and 0.816 and 0.714 in the testing set for 3- and 5-year recurrence risk, respectively. The combined model incorporating the risk score, pN, and endocrine therapy showed improved predictive power, with AUCs of 0.857 and 0.912 in the training set and 0.943 and 0.945 in the testing set for 3- and 5-year recurrence risk, respectively. The calibration curve of the combined model showed good consistency between predicted and measured values. Our study developed an MRI-based radiomics model that integrates clinical and radiomics features to assess the likelihood of recurrence in luminal B breast cancer. The model shows promise for improving clinical risk stratification and treatment decision-making.
The invention relates to immune cells treated by magnetic fieldAnd uses thereof. According to the invention, a moderate electrostatic field with a strength of 0.3T can promote mouse CD8 + Secretion of T cell granzyme and cytokines, and increased levels of ATP and mitochondrial respiration, and up-regulated expression of mitochondrial respiratory chain-associated genes Uqcrb and/or Ndufs 6. In addition, magnetic receptor candidate genes Isca1 and Cry1/Cry2 are involved in regulating the expression of Uqcrb and/or Ndufs 6. In vivo experiments show that static magnetic field can promote CD8 + The secretion of T cell granzymes and cytokines inhibits tumor growth and development. Killing ability tests show that static magnetic field treatment can enhance CD8 + Killing ability of T cells, and application of magnetic field-treated CD8 + The T cells are back-transfused into tumor grafted mice to have obvious anti-tumor effect. It is not only disclosed herein that a medium strength static magnetic field can enhance CD8 by promoting mitochondrial respiration + T cell killing ability, and provides a new method for enhancing CD8 by physical method + Anti-tumor function of T cells.
BACKGROUND: Kawasaki disease shock syndrome (KDSS) is a critical manifestation of Kawasaki disease (KD). In recent years, a logistic regression prediction model has been widely used to predict the occurrence probability of various diseases. This study aimed to investigate the clinical characteristics of children with KD and develop and validate an individualized logistic regression model for predicting KDSS among children with KD.
METHODS: The clinical data of children diagnosed with KDSS and hospitalized between January 2021 and December 2023 were retrospectively analyzed. The best predictors were selected by logistic regression and lasso regression analyses. A logistic regression model was built of the training set (n = 162) to predict the occurrence of KDSS. The model prediction was further performed by logistic regression. A receiver operating characteristic curve was used to evaluate the performance of the logistic regression model. We built a nomogram model by visualizing the calibration curve using a 1000 bootstrap resampling program. The model was validated using an independent validation set (n = 68).
RESULTS: In the univariate analysis, among the 24 variables that differed significantly between the KDSS and KD groups, further logistic and Lasso regression analyses found that five variables were independently related to KDSS: rash, brain natriuretic peptide, serum Na, serum P, and aspartate aminotransferase. A logistic regression model was established of the training set (area under the receiver operating characteristic curve, 0.979; sensitivity=96.2%; specificity=97.2%). The calibration curve showed good consistency between the predicted values of the logistic regression model and the actual observed values in the training and validation sets.
CONCLUSION: Here we established a feasible and highly accurate logistic regression model to predict the occurrence of KDSS, which will enable its early identification.
This is a Phase I, first-in-human, open-label, non-randomized, dose-escalating study of Tanibirumab which is a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR2/KDR). This study will enroll patients with advanced or metastatic cancer who are refractory or for whom there are no standard therapeutic options. Tanibirumab will be administered intravenously to such patients over 60 minutes on Day 1, 8, and 15 (subject to change pending PK and toxicity data). Each treatment cycle will be a minimum of 28 days in length. The dose escalation study employing a 3 + 3 design is designed to identify the RP2D which will be based on safety, tolerability and PK of the RP2D. This study is expected to enroll a total of approximately 18-24 patients.
NEW MATERIAL:A lactic compound expressed by formula I [R<1> is lower alkoxycarbonyl-(lower)-alkyl or nitro-substituted phenyl (lower)- alkoxycarbonyl-(lower)-alkyl; X is halogen], reactive derivative in carboxyl group of the lactic compound usable in acylation reaction and salts thereof. EXAMPLE:4-Chloro-2-methoxycarbonylmethoxyimino-3-oxolactic acid. USE:Useful as a syn isomer of 7-acylamino-3-vinylcepharosporanic acid derivative having antimicrobial activity and synthetic intermediate for salts permissible as medicine thereof. PREPARATION:The aimed compound expressed by formula I is obtained from a compound expressed by formula II. Specifically, the aimed compound is obtained from 2-methoxycarbonylmethoxytmino-3-oxolactic acid tert. butylester obtained by starting from 2-hydroxyimino-3-oxolactic acid tert. butylester and sulfuryl chloride.
The invention discloses a traditional Chinese medicine composition for preventing grass carp hemorrhagic disease and a preparation method thereof, and belongs to the technical field of veterinary traditional Chinese medicine. The traditional Chinese medicine composition is mainly composed of the following traditional Chinese herbals in parts by weight: 70 to 130 parts of cyanotis arachnoides, 150 to 250 parts of isatis root, 150 to 250 parts of radix scutellariae, 70 to 130 parts of rheum officinale, 150 to 250 parts of coptis, and 70 to 130 parts of licorice. The traditional Chinese herbals are compounded according to the principle of "monarch, minister, assistant and guide" in the traditional Chinese medicine theory. In the formula, cyanotis arachnoides is taken as the monarch drug, contains a plurality of ketosteroid compounds, and is capable of preventing bacteria in a wide spectrum and viruses. Radix scutellariae, rheum officinale and licorice are taken as the minister drugs, and have the functions of clearing heat, removing toxicity, and relieving symptoms. Isatis root and coptis are taken as the guide drugs to assist the cyanotis arachnoides to exert the antibacterial and antivirus functions. The traditional Chinese herbals are co-used to generate the functions of preventing viruses, eliminating inflammation, and preventing grass carp hemorrhagic disease. The traditional Chinese medicine composition is mainly used to treat grass carp hemorrhagic disease, and has the advantages of prominent curative effect and rapid effect. Isatis root, radix scutellariae, and coptis all have the antibacterial and antivirus functions, and the three traditional Chinese herbals are co-used to generate a synergic antivirus effect.
Colorectal cancer is the third most common malignant tumor. In 2020, there were nearly 1.9 million new cases worldwide, accounting for about 10% of all new malignant tumors, and the related death exceeded 900,000. In recent years, the incidence of colorectal cancer in our country has been rising rapidly year by year, with more than 400,000 new cases each year, leading China to the largest number of colorectal cancer cases in the world. For resectable non-metastatic colorectal cancer, radical surgical resection is the mainstay of treatments. Compared with the open surgery, the laparoscopic colorectal cancer resection has smaller wounds, faster postoperative recovery, and shorter hospital stay. The 10-year results of the COLOR trial showed similar DFS, OS, and recurrence rates between open and laparoscopic surgery for colon cancer. In another trial (COST study), 872 patients with colon cancer were randomly assigned to open surgery or laparoscopic-assisted colectomy for curative colon cancer. After a median follow-up of 7 years, the 5-year recurrence rates and the 5-year OS rates were similar.

Traditional laparoscopic colorectal cancer resection can be carried out smoothly by close cooperation between the surgeon and the assistant. However, inexperienced assistants are likely to cause parainjuries due to the opposite field of the view and the narrow operating space. In recent years, single-port laparoscopy gradually goes into service. However, it is easy to cause instrument conflicts, straight-line viewing angles, and lack of traction. Therefore, single-port surgery is extremely unergonomic and difficult for the surgeon. Reduced-port laparoscopic surgery has been selectively used in some colon cancer anticipants. Reduced-port laparoscopic surgery reduces or completely eliminates the assistant's operating ports, and the surgeon mainly relies on himself/herself to complete the exposure of the operative field. However, reduced-port laparoscopy has some potential advantages and applications. Reduced-port laparoscopic surgery is completed by the left and right hands of the surgeon, which is easier to coordinate, avoiding the prolongation of the operation time or even concomitant injury caused by the poor cooperation of the inexperienced assistant and the surgeon. Reduced-port laparoscopy reduces some surgical incisions, and extreme minimally invasive may result in less pain and faster recovery. From an economic point of view, the reduced-port laparoscopy reduces some surgical consumables and human resouce, leading to reduced cost of surgery.

In order to further explore the application of reduced-port laparoscopic surgery in patients with resectable colorectal cancer, the center plans to carry out a clinical study of 'reduced-port laparoscopic surgery versus traditional laparoscopic surgery for resectable colorectal cancer', aiming to evaluate the complications associated with perioperative surgery, R0 resection rate, 3-year disease-free survival rate, and 3-year overall survival rate.
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease all over the world (1). In early 2020, a new definition of MAFLD has been proposed and is becoming increasingly widely accepted. The new diagnostic criteria are based on the histology or imaging of liver biopsies, or even blood biomarker tests indicative of the presence of fatty liver while satisfying any one of the following three conditions: overweight/obesity, type 2 diabetes, or metabolic dysfunction (2). The information on the prevalence of MAFLD is scarce. This study is designed to conduct MAFLD screening in adults with health check-ups at multiple health examination centers across China. The primary objective is to investigate the prevalence of MAFLD among adults in China.
Geranylgeranylacetone (GGA), an isoprenoid compound widely utilized as an antiulcer agent in Asia, confers protection against ischemia, anoxia, and oxidative stress by rapidly enhancing the expression of HSP70. Nevertheless, the impact of GGA on sepsis-associated intestinal injury remains unexplored. Thus, this study is crafted to elucidate the protective efficacy and underlying mechanisms of GGA against septic intestinal damage. Our findings revealed that GGA significantly extended the survival duration of septic mice, and mitigated lipopolysaccharide (LPS)-induced alterations in intestinal permeability and tissue damage. Furthermore, GGA effectively suppressed LPS-induced cytokine release, attenuated levels of reactive oxygen species (ROS) and malondialdehyde, and bolstered antioxidant-related parameters within the intestinal tissue of LPS-stimulated mice. Mechanistically, GGA significantly increased HSP70 expression and promoted E3 ubiquitin ligase CHIP to play the role in ubiquitination and degradation of karyopherin-α2 (KPNA2), resulting in inhibition of nuclear translocation of NF-κB and reduced NOX1, NOX2 and NOX4 expression. The inhibitory action of GGA on cytokine release and ROS generation was abolished by CHIP knockdown in IEC-6 cells treated with LPS. Simultaneously, the downregulation of CHIP reversed the suppressive role of GGA in the LPS-induced NF-κB activation and the expression of NOX1, NOX2 and NOX4 in IEC-6 cells. The effects of GGA on mitigating intestinal damage, inflammation and oxidative stress caused by LPS were eliminated in CHIP knockout mice. Our results demonstrate that the protective effect of GGA against LPS-caused intestinal injury of mice is dependent on CHIP activation, which promotes KPNA2 degradation and restrains translocation of NF-κB into nucleus, leading to suppressing LPS-induced inflammatory response and oxidative stress.
Arm includes dietary manipulation in the free-living setting to include potatoes/potato products frequently in the diet (5-7 days / week). Control diet will be prescribed for weight maintenance.
Deep Friction Massage treatment will be given for 3 weeks, 3 days in a week. Massage duration will be 10-15 min. for each session. Moreover 10-12 minutes cold pack will apply for every session. Also Mill's manipulation technique will applied once a week during 3 weeks.
The invention discloses chrysanthemum flower formula granules, and a preparation method and quality control method thereof. The preparation method comprises the following steps: carrying out supercritical extraction and aqueous extraction on the raw material chrysanthemum flower herbal pieces twice, concentrating under reduced pressure, carrying out spray drying, and the like to obtain the chrysanthemum flower formula granules. Every gram of chrysanthemum flower formula granules is equivalent to 8-12 grams of crude drug. The chrysanthemum flower formula granules are subjected to quality identification by thin-layer chromatography. On the basis of the traditional Chinese medicine decoction, the invention combines the modern high-tech extractor, pharmaceutical technology and thin-layer chromatographic scanning technology, refers to the research of chrysanthemum flower chemical composition to perform extraction process research and thin-layer chromatography identification method research on the chrysanthemum flower, thereby obtaining the chrysanthemum flower formula granules which can be taken by being directly dissolved before use. The medicine preserves the fragrance of the raw drug, can implement complete component extraction, has the advantages of scientific production and controllable quality, and can implement large-scale production. The medicine is convenient and sanitary to take, and convenient for storage.
The invention provides a traditional Chinese medicine pillow. The traditional Chinese medicine pillow comprises a pillow inner and a traditional Chinese medicine. The pillow inner is filled with the traditional Chinese medicine. The traditional Chinese medicine consists of the following raw materials in part by weight: 1-3 parts of safflower carthamus, 1-3 parts of myrrh, 1-3 parts of frankincense, 2-4 parts of lycopodium clavatum, 2-4 parts of garden balsam stems, 2-4 parts of Chinese parsnip roots, 3-4 parts of radix angelicae pubescentis, 3-4 parts of roots of kudzu vine, 1-2 parts of tortoiseshell, 2-4 parts of salvia chinensis, 2-4 parts of borneol, 1-3 parts of roots of common peony, 4-6 parts of chrysanthemum, 1-3 parts of mint, 1 part of radix angelicae, 1 part of notopterygium roots, 1 part of ligusticum wallichii, 1 part of radix clematidis, 1 part of obscured homalomena rhizome, 1 part of cassia twigs, 1 part of radix aconiti kusnezoffii and 0.5 part of borneol. The various medicinal materials are respectively cut into slices with the length of 0.5-1cm, and are filled in the pillow inner proportionally. The traditional Chinese medicine health-care pillow is simple in formula and manufacturing process and comfortable to use, does not have toxic and side effects, and is multipurpose; and raw material resources are abundant and are easy to purchase.
Participants who are allocated to this group will perform the same exercise program performed by the STG, but with the addition of exercises that emphasize power gain. As in the other group, initially, the objective will be the development of neuromotor control and resistance (load \<50% of the one repetition maximum test \[1RM\]). However, in subsequent weeks the goal will be to develop strength (load\> 70% 1RM) and muscle power (load between 40-60% 1RM).
Codeine was microinjected into the area of the Kölliker-Fuse nucleus and the adjacent lateral parabrachial nucleus, within the pontine respiratory group in 8 anesthetized cats. Electromyograms (EMGs) of the diaphragm (DIA) and abdominal muscles (ABD), esophageal pressures (EP), and blood pressure were recorded and analyzed during mechanically induced tracheobronchial cough. Unilateral microinjections of 3.3 mM codeine (3 injections, each 37 ± 1.2 nl) had no significant effect on the cough number. However, the amplitudes of the cough ABD EMG, expiratory EP and, to a lesser extent, DIA EMG were significantly reduced. There were no significant changes in the temporal parameters of the cough. Control microinjections of artificial cerebrospinal fluid in 6 cats did not show a significant effect on cough data compared to those after codeine microinjections. Codeine-sensitive neurons in the rostral dorsolateral pons contribute to controlling cough motor output, likely through the central pattern generator of cough.
Every patient will be subjected to a measured stimulus with a power selected in phase 1 (X mA) and pupillary dilatation will be measured by pupillometry. In those patients showing pupillary size variation over the limit for insufficient analgesia estimated in phase 1 for tracheal suction, additional analgesia will be provided before tracheal suction. In those patients without pain detected by pupillometry, additional anlagesia won´t be provided. In both cases Pupillometry, BPS and ESCID will be measured during tracheal suction to determine whether the patient is in pain or not.
The study will evaluate the efficacy of premixed nitrous oxide and oxygen (MEOPA) in patients with out-of-hospital moderate acute pain.

The primary endpoint is the percentage of patients with pain relief (with a numerical rating scale of 3/10 or lower) 15 minutes after randomisation. Secondary endpoints are treatment safety and adverse events, time to analgesia and duration of analgesia. This study will expect 60 patients assigned in two parallel groups, defined by a randomization scheme. Group assignments were sealed in opaque envelopes and will be open sequentially by the dispatcher when the paramedic is ready to include the patient. The letter contained in the envelope corresponds to the cylinder to use. Eligible patients with a numeric rating scale (NRS) score between 3 and 6/10 are randomly allocated to receive either MEOPA, or medical air. Fifteen minutes after the randomisation, all patients will receive MEOPA from a distinct cylinder. Pain score will be measured at baseline and every 5 minutes until pain relief will be obtained. The paramedic blinded to the analgesic treatment groups will do all assessments of patients. The safety evaluation will include non invasive monitoring of blood pressure, heart rate, oxygen saturation by pulse oximetry (SpO2) and adverse events collection.
This disclosure provides methods of selecting a therapeutic bacteriophage and identifying bacteria in a sample. The sample may be obtained from a plant or animal subject diagnosed with a disease caused by a bacterial infection or an object suspected of being exposed to a bacterium. The activity of reporter molecules, either encoded in the bacteriophage genome or added during sample analysis, is used . to determine whether bacteriophages are capable of infecting assayed bacteria. Also provided are methods of selecting a bacteriophage for potential use in treating of bacterial infection, based upon the selectivity of the bacteriophage host range for the bacterium. The bacteriophages .or bacteria may be immobilized in an array, such that multiple bacteriophages and/or bacteria may be assayed. Kits are also provided.
PURPOSE: A medicinal and pharmaceutical composition and food composition for preventing or treating cerebrovascular disease containing phytoceramide are provided to effectively protect ischemic and oxidative damage. CONSTITUTION: A medicinal and pharmaceutical composition for preventing or treating cerebrovascular disease contains a phytoceramide of structural formula 1 as an active ingredient. In structural formula 1, A is saturated or unsaturated alkyl of C11-C23. The phytoceramide is obtained from rice hull, soybean, corn, chestnut, sweet potato, potato, apple, pumpkin, rice, carrot, or onion. The phytoceramide is contained in 0.001-99.99 weight%. The composition is used in the form of tablets, pills, chewing agents, powders, elixirs, suspensions, emulsions, liquids, syrups, aerosols, or soft and hard gelatin capsules.