anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine. SUBSTANCE: proposed substance may be used in cosmetology for inhibition of process of skin withering and also for treatment of diseases caused by disturbances of process of collagen synthesis in human organism, in particular, arthroses, dermatoses and various forms of paradontosis. Biologically active substance contains lanolin or glycerin, and emulsion of liposomes comprising primary nutrient and water. Used as a primary nutrient, liposomes contains hydroxylated proline and/or lysine. The substance contains the ingredients in the following ratio, mas.%: lanolin or glycerin, 50.0-70.0; 10-20-% liposomes emulsion with 10-30-% aqueous solution of hydroxylated proline and/or lysine, 10.0-15.0; water, the balance. Liposomes may have an antioxidant in the amount of 0.5-1.5 mas.%. Ional may be used as an antioxidant. EFFECT: effective action to withering skin. 3 cl, 2 tbl
Patients will take axitinib tablets 5 mg by mouth twice daily continuously. There may be one dose reduction to 3mg twice daily.
BACKGROUND: Knee osteoarthritis (OA) is a leading cause of disability among the elderly and is often exacerbated by obesity. Research supports weight loss and exercise therapy as key strategies for managing knee OA-related disability. Concurrently, telemedicine is becoming a popular healthcare approach. This study aimed to develop and evaluate an 8-week tele-education programme's impact on weight control and knee OA outcomes.
METHODS/DESIGN: Participants with knee OA and obesity were included. Baseline data on pain (VAS index), physical activity (GPAQ questionnaire), and quality of life (EQ5D and KOOS questionnaires) were collected. Performance tests, including the 30-second Chair Stand test (30CST) and the Timed Up-and-Go test (TUG), were recorded. Participants were randomly divided into two groups: a control group receiving oral advice on diet and exercise, and an intervention group receiving educational videos on nutrition, lifestyle changes, physical activity, individualised exercises, and psychosocial support. Evaluations were repeated after 8 weeks.
RESULTS: Data from 25 of 30 participants were analysed. In the intervention group, body composition, waist, and abdominal circumference decreased significantly (p < 0.05). The KOOS questionnaire showed significant improvements in pain, activity, and daily tasks (p = 0.00). The EQ5D questionnaire and health satisfaction also showed positive results within the intervention group (p = 0.00) and between groups (p = 0.008). The pain index improved significantly within (p = 0.00) and between groups (p = 0.02). Functional test results were significant within the intervention group (p = 0.00) and between groups (p = 0.017 for 30CST and p = 0.004 for TUG).
CONCLUSION: An 8-week tele-education programme for weight control and exercise therapy in knee OA patients significantly improved body composition, quality of life, and functional performance. Given the costs of obesity and knee OA on both people and the health system, tele-education can be a cost-effective treatment strategy.
Hypertrophic scarring is a frequent endpoint after traditional surgical excision of skin cancers of the chest. These scars create significant long-term morbidity to the patient. There is a clinical need for an alternative treatment that would reduce factors associated with hypertrophic and possibly keloid scar formation by providing minimal tension, low infection risk and an absence of foreign body material. This would result in a normal appearing and healed scar without associated patient morbidity. Photochemical tissue bonding may provide this alternate treatment. PTB differs from sutures by continuously joining the tissue surfaces on a molecular level rather than only at discrete suture points. In addition, PTB does not incite foreign body reactions nor create tissue injury during passage of the needle and tying a knot, injuries that may initiate scarring.
The invention relates to the field of immunology, in particular to a preparation method of a recombinant antigen for detecting chronic interstitial nephritis. The invention provides a method for efficiently fermenting and producing beta 2-microglobulin by using recombinant pichia pastoris. Compared with a recombinant escherichia coli expression system, the invention overcomes the problems of easy formation of inclusion bodies, difficult renaturation, easy loss of immunological activity and the like. Methanol is used as an induction carbon source to promote the expression of the AOX1 gene, thereby improving the expression quantity of the target protein. Increasing the nitrogen source content of the fermentation liquor, adopting a method of constant-current feeding and supplementing urea and batched supplementing peptone, and controlling the optimum pH by using ammonia water, maintaining the appropriate carbon-nitrogen ratio, and providing the required substances for the synthesis of the target product. The invention shortens the induction time and improves the feed supplement rate, so that the degradation condition of the foreign protein is improved, and the expression quantity is improved in the same induction time. And the result correlation is good, the accuracy is high, the change of the antigen concentration can be accurately characterized, the operation is simple, and the clinical application is wide.
PURPOSE:To obtain the subject composition capable of preventing the activity of triclosan from deteriorating with an alkyl sulfate and exhibiting high inhibiting effects on the formation of bacterial plaques by blending a composition containing the triclosan and an alkyl sulfate-based surfactant blended therein for the oral cavity with a water-soluble tin salt. CONSTITUTION:A composition for the oral cavity is obtained by adding a water- soluble tin compound such as stannous fluoride to a system containing triclosan and an alkyl sulfate-based surfactant (e.g. sodium lauryl sulfate) used in combination. Thereby, the deterioration in germicidal power of the triclosan in the surfactant is inhibited. The pH of the composition is preferably regulated to 5-6.5. The composition is capable of exhibiting inhibiting effects on the formation of bacterial plaques by powerful germicidal action and effective in preventing periodontosis. The triclosan is blended in an amount of preferably 0.01-0.5% and the water-soluble tin salt is blended in an amount of preferably 0.1-2%.
A method for co-registering imagery of different modalities includes accessing a first image captured according to a first imaging modality that depicts a plurality of physical markers. The plurality of physical markers is present within a scene represented in the first image. The method includes accessing a second image captured according to a second imaging modality that captures at least a portion of the scene including the plurality of physical markers. The method further includes generating a transformation matrix using the first image data and the second image data and generating an aligned image by applying the transformation matrix to the first image or the second image. The aligned image is combinable with the first image or the second image to generate co-registered image output. The co-registered image output depicts the portion of the scene according to the first imaging modality and the second imaging modality.
All participants will undergo clinical testing prior to placement of the pessary and the investigator will test their vaginal environment prior to pessary placement. Testing will consists of a vaginal swab (AIM 1) and 10 mL of vaginal lavage (Aim 2) at each study visit. The participant will then be followed, and repeat testing obtained at the standard clinical interval for pessary follow-up, every three months. Should the participant discontinue pessary use, we will additionally culture the microbes that are present on the pessary and compare those to the vaginal microbiota.
PURPOSE: This study was to examine whether higher dietary carotenoid intake levels were associated with a lower prevalence of kidney stones.
MATERIALS AND METHODS: This study analyzed data from 2007 to 2018 National Health and Nutrition Examination Survey (NHANES) project. Dietary carotenoid intake (α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin) was assessed using two 24-h dietary recall interviews. Multiple logistic regression and weighted quantile sum (WQS) regression were applied to examine the associations between five dietary carotenoids alone, compounds, and the prevalence of kidney stones. The dose-response relationships were analyzed by restricted cubic spline regression.
RESULTS: A total of 30,444 adults (2909 participants with kidney stones) were included in the analysis. The mean age of the participants was 49.95 years and 49.2% of the participants were male. Compared with the first quartile, the fourth quartile of α-carotene (odds ratio [OR] = 0.82 [0.73-0.92]), β-carotene (OR = 0.79 [0.70-0.89]), β-cryptoxanthin (OR = 0.88 [0.79-0.99]), and lutein/zeaxanthin (OR = 0.80 [0.71-0.91]) were significantly and inversely associated with the prevalence of kidney stones after adjusting for confounders. The dose-response analysis showed a linear relationship between five dietary carotenoid intake levels and the prevalence of kidney stones. Further WQS analysis revealed that the combination of all five dietary carotenoids was negatively associated with and the prevalence of kidney stones, with the largest effect coming from β-carotene (weight = 0.538).
CONCLUSION: Our findings indicated that higher dietary carotenoid intake levels were associated with decreased prevalence of kidney stones, and increasing the intake of foods rich in β-carotene may prevent the development of kidney stones.
UNLABELLED: Physical activity avoidance and fear of movement (FOM) is often observed in individuals with chronic musculoskeletal pain, along with difficulties coping with pain. There is little research regarding how FOM may also relate to reduced physical strength and altered movement patterns that may perpetuate a cycle of pain, FOM, and disability. The objective of this observational study was to compare how adolescents with juvenile fibromyalgia (JFM) exhibiting high versus low FOM (Tampa Scale of Kinesiophobia-11) differed on patient-reported measures of pain, fatigue, catastrophizing and pain interference, and performance-based measures of strength, postural control, and biomechanical function. Participants were youth with JFM (N = 135, Meanage = 15.6 years, 88.9% female) enrolled in an ongoing clinical trial who completed self-report questionnaires and standardized tests, including knee and hip strength, the Star Excursion Balance Test, and the Drop Vertical Jump (with 3 dimensional motion capture). Participants were categorized into Low, Medium, and High FOM groups based on Tampa Scale of Kinesiophobia-11 tertile scores. Relative to the Low FOM group, the High FOM group reported significantly greater fatigue, pain interference and catastrophizing, as well as reduced dominant leg knee strength. Additionally, those with high FOM showed altered lower-extremity movement patterns. This preliminary study highlights the importance of combining self-reported measures of symptoms and functioning with physical assessments to gain a more comprehensive view of the impact of FOM in patients with chronic musculoskeletal pain. The results could inform the development of more precise interventions to reduce FOM using a combination of behavioral and exercise-based interventions.
PERSPECTIVE: The results of this study demonstrate the association between FOM, fatigue and pain interference in adolescents with JFM, as well as preliminary evidence for altered movement patterns in that may predispose them to further pain/injury and activity avoidance.
GOV REGISTRATION: NCT03268421.
INTRODUCTION: Early mobilization and rehabilitation of critically ill patients in the Intensive care unit (ICU) is a topic of growing interest. Current evidence suggests that early mobilization is safe, feasible, and effective at reducing the incidence of ICU-acquired weakness. However, early mobilization is still not the standard of care in most ICUs worldwide. The aim of the study was to determine the level of knowledge, perceptions, and practice among ICU physiotherapists of early mobilization in critically ill ICU patients in Malaysia.
MATERIALS AND METHODS: A cross-sectional study was undertaken in 45 public, teaching, and private hospitals in Malaysia that provide ≥ 10 beds in their ICUs. Knowledge, perceived barriers, facilitators, and practice of early mobilization were assessed using a previously validated mobility survey questionnaire.
RESULTS: Only 35% of ICU physiotherapists reported receiving training/courses on early mobilization in the ICU. 100 (86%) physiotherapists underestimated the incidence of ICU-acquired weakness, and 88 (75%) were unfamiliar with the current literature on early mobilization in the ICU. The need for physician orders before mobilization, medical instability, excessive sedation, and risk of dislodgement of devices or lines were the most common barriers to early mobilization. Nearly half (49 [42%]) of the respondents reported physiotherapist as early mobilization clinical champion in their setting, but the most common physiotherapy treatment techniques in the ICU reported by the respondents' were still chest physiotherapy, range of motion exercises, and bed mobility.
CONCLUSION: We observed strong enthusiasm for early mobilization among Malaysian physiotherapists. Most respondents believed that early mobilization is important and beneficial to ICU patients. However, there is still a big gap in knowledge and training of early mobilization in ICU patients among Malaysian physiotherapists.
PURPOSE: A composition containing diterpene compound with kauran skeleton is provide to enhance proliferation ability of skin stem cells and epithermal keratinocytes and to prevent or treat skin injury. CONSTITUTION: A pharmaceutical composition for preventing or treating skin injury due to UV ray contains Siegesbeckia extract as an active ingredient. The skin injury is burn, erythema, or pigmentation on epidermis or dermis. The Siegesbeckia extract is obtained using water, alcohol of C1-C4, or mixture thereof. A cosmetic composition for treating skin injury due to UV ray contains the Siegesbeckia extract as an active ingredient. A pharmaceutical or cosmetic composition for preventing or treating skin injury due to UV ray contains a compound of chemical formula 1.
The participants will perform moderate intensity exercise at 50% WMAX (determined during maximal workload test) under normoxia (FiO2: 21%) two times 30 minutes per day for 4 consecutive days on a cycle ergometer. 24h glucose concentration will be monitored continuously. Afterwards, a meal test challenge test will be performed at day 5 to determine fasting/postprandial substrate oxidation.
The invention discloses a wasp rheumatic health-care wine for alleviating pain. The invention is characterized in that the wasp rheumatic health-care wine for alleviating pain is prepared by soaking wasps and 23 traditional Chinese medicines, including notopterygium root, heracleum hemsleyanum michaux, panicled swallowwort root, radix gentianae macrophyllae and the like, in 36-55 vol% pure white rice wine. The health-care wine has the functions of expelling wind and removing dampness, treating rheumatism and rheumatic diseases, alleviating pain and eliminating subsidence of swelling. The health-care wine is very suitable for treating arthralgia due to wind-cold-dampness, rheumatoid arthritis, chronic infectious arthritis, periarthritis humeroscapularis, limb pain, soreness and weakness of the waist and knees, limb numbness and other symptoms. When being drunk as a common beverage, the health-care wine has the effects of tonifying the kidney, strengthening the bone, relaxing muscles and tendons, activating the collaterals, treating sciatica and lumbar muscle strain and the like, and is a health-care medicinal wine with both treatment and health-care effects. The health-care wine is suitable for various people.
Prior to electrode implantation we perform stereotactic imaging which requires the fixation of a stereotactic frame on the patient's head before imaging (Magnetic Resonance Imaging MRI / Computed Tomography CT). Currently, it is necessary to transfer the patient to the imaging department outside of the operating room after the stereotactic frame has been placed, for imaging (either MRI or CT) and then to return to the operating room to begin the electrode implantation procedure. Since 2016, the new generation O-Arm 2 allows the acquisition of stereotactic imaging with the stereotactic frame in place by increasing the field of view (40 cm versus 20 cm previously) directly in the operating room. As a result, the transfer step to the MRI and CT scanner preoperatively may no longer be necessary, and the procedure can be started more quickly with greater comfort and safety for the patient and the anaesthesia team. Several teams around the world have begun to use framed O-Arm as the gold standard for stereotactic imaging. However, no randomised controlled study has been performed to date comparing O-Arm stereotactic imaging with pre-operative CT and/or MRI reference imaging.
One day before surgery: Colchicine 1.2 mg with 0.6 mg PO one hour later. This load will be followed by colchicine 0.6 mg twice daily for a total of 14 days.
Fludarabine, Cyclophosphamide, TBI followed by bone marrow transplantation. Post-transplant Cyclophosphamide will be on Days 3 \& 4.
OBJECTIVES: The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI).
METHODS: The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50 years old. Clinical exam objective measures were collected such as patient questionnaires, somatosensory tests, HL range of motion, and a mSLR test, and were compared to the findings from a structural lumbar spine MRI.
RESULTS: There were no significant differences in mean HL angulation and mSLR angulation between LBP and healthy subjects (p>0.05). There was no significant difference in mean HL by impingement by versus no impingement (38.3±15.6 versus 44.8±9.4, p = 0.08, Cohen's d = 0.50). On the other hand, there was a significant difference in mean mSLR angulation by impingement (57.6.3±8.7 versus 63.8±11.6, p = 0.05, Cohen's d = 0.60).
CONCLUSIONS: The mSLR test was found to be associated with lumbar nerve root compression, regardless of the existence of radiating leg symptoms, and showed no association solely with the report of LBP. The findings highlight the diagnostic dilemma facing clinicians in patients with chronic nonspecific LBP with uncorrelated neuroanatomical image findings. Clinically, it may be necessary to reevaluate the common practice of exclusively using the mSLR test for patients with leg symptoms. This study may impact the way chronic LBP and neuropathic symptoms are diagnosed, potentially improving treatment methods, reducing persistent symptoms, and ultimately improving disabling effects.
Background: Muscle-invasive bladder cancer (MIBC) is a potentially fatal disease, especially in the setting of locally advanced or node-positive disease. Adverse outcomes have also primarily been associated with low-income status, as has been reported in other cancers. While the adoption of neoadjuvant cisplatin-based chemotherapy (NAC) followed by radical cystectomy (RC) and pelvic lymph node dissection (PLND) has improved outcomes, these standard-of-care treatments may be underutilized in lower-income patients. We sought to investigate the economic disparities in NAC and PLND receipt and survival outcomes in MIBC. Methods: Utilizing the National Cancer Database, a retrospective cohort analysis of cT2-4N0-3M0 BCa patients with urothelial histology who underwent RC was conducted. The impact of income level on overall survival (OS) and the likelihood of receiving NAC and PLND was evaluated. Results: A total of 25,823 patients were included. This study found that lower-income patients were less likely to receive NAC and adequate PLND (≥15 LNs). Moreover, lower-income patients exhibited worse OS (Median OS 55.9 months vs. 68.2 months, p < 0.001). Our findings also demonstrated that higher income, treatment at academic facilities, and recent years of diagnosis were associated with an increased likelihood of receiving standard-of-care modalities and improved survival. Conclusions: Even after controlling for clinicodemographic variables, income independently influenced the receipt of standard MIBC treatments and survival. Our findings identify an opportunity to improve the quality of care for lower-income MIBC patients through concerted efforts to regionalize multi-modal urologic oncology care.
1414243 Shampoo composition COLGATEPALMOLIVE CO 10 Oct 1973 [16 Oct 1972] 47359/73 Heading C5D Shampoo compositions comprise: (a) a lower polar phase which comprises amphoteric and cationic surfactants, water and a C 2  to C 4  alkanol and (b) an upper stable emulsion phase comprising a major proportion of hydrocarbon oil. The amphoteric surfactant may be a C 10 -C 18  alkyl amino C 2 -C 6  alkanoic acid, and the cationic surfactant may be a quaternary ammonium compound which contains at least two C 1 -C 4  alkyl groups and at least one C 10 -C 18  alkyl group or a benzyl group. The polar phase may also include a C 10 -C 18  alkyl di C 1 -C 6  alkyl amine oxide, a C 10 -C 18  fatty acid alkanolamide and a sequestrant such as citric acid. The hydrocarbon oil of the emulsion phase may be a saturated light mineral oil, but minor amounts of vegetable oil, such as olive oil, may also be used. Hydrolysed protein, perfume, fluorescent brighteners and dyes may also be present. The compositions are prepared in homogeneous form and phase separation may take place during storage.
There are circumstances where tumors can only be partially resected. Therefore, multimodality therapy targeting post-operative residuals is important. Here, we show that bioorthogonal click chemistry enables targeted delivery to heterogeneous tumors, but its utility against tumor post-debulking is ineffective due to platelet cloaks that shield tumor cells from bioorthogonal pairing. We further discover tumor-infiltrating platelet levels respond to local pH changes. Elucidating this pH-platelet linkage, we design an injectable hydrogel for resection cavity implantation that simultaneously azido-tags tumor cells and inhibit their catalysis to acidify surrounding milieu. Unlike transient buffering, tumor acidification blockade sustains pH normalization, leading to durable platelet reduction. This reinstates bioorthogonal targeting of dibenzyl cyclooctyne-modified nanoparticles, thereby enhancing photodynamic ablation of residuals while amplifying systemic antitumor immunity. Concurrently, platelet/pH normalization interrupts metastasis cascade from invasion to circulation to colonization. Overall, attenuating tumor pH-platelet linkage unlocks bioorthogonal chemistry as a potential option for adjuvant therapy after tumor debulking.