anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide an anticancer agent, and a medicine for prophylaxis and/or treatment of cancer diseases associated with a C5a-C5aR signal transmission system, and to provide a test agent to the cancer diseases.  <P>SOLUTION: Cancer cells express C5aR on the surface of the cells, and C5a has concentration-dependently an infiltration accentuation action to the cancer cells. Isolation of C5a from C5 by cancer cell membrane protease is inhibited using a serine protease inhibitor, and the infiltration accentuation action of the cancer cells caused by C5a is inhibited using an anti-C5a antibody or an anti-C5a acceptor antibody. A test subject can be tested whether the test subject is affected by the cancer or not, using the anti-C5a antibody and/or the anti-C5a acceptor antibody, and a biological sample obtained from the test subject such as urine, cells, blood, tissue, and an organ. Hence, the test agent to cancer diseases includes the anti-C5a antibody and/or the anti-C5a acceptor antibody.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Female health-care givers aged 45 to 64 years. The study participants will be recruited from UMC (Clinical Academic Department (CAD) of Women's Health, Pediatric Clinical Academic Department, Republic Diagnostic Center (RDC) and National Center for Children's Rehabilitation (NCCR)), Nur-Sultan, Kazakhstan.
Patients with psoriasis in the Department of Dermatology, Xijing Hospital of Air Force Medical University from December 2012 to December 2022 were consecutively collected. Inclusion criteria: (1) age ≥18 years; (2) Clear diagnosis of psoriasis. Exclusion criteria: (1) age \<18; (2) Hypertension caused by conditions such as primary hypertension, hyperthyroidism, chronic renal insufficiency, or Cushing's syndrome, which are severe endocrine system diseases; (3) Patients with autoimmune diseases, severe cardiovascular, hepatic, renal, or other major organ disorders, as well as blood disorders and endocrine system diseases.
Bleeding peptic ulcer is a life-threatening emergency. Endoscopic therapy is a proven technique in the acute hemostasis of bleeding ulcers. Currently there is no objective assessment of adequacy of endoscopic therapy. Endoscopic Doppler ultrasound enables endoscopists in detecting blood flow in a vessel beneath an ulcer. A persistent signal after endoscopic therapy predicts recurrent bleeding. The current study proposes to compare assessment of ulcer base using either Doppler ultrasound or endoscopists' interpretation of ulcer floors. The trial design is one of a prospective randomized controlled cross-over study in which patients with severe upper gastrointestinal bleeding and documented peptic ulcers at endoscopy are enrolled.
New water-soluble low-mol. -wt. ligniod prod. is produced by (a) contacting natural or synthetic lignin with O2 in an alkaline medium in the presence of an oxidn. catalyst and isolating the water-soluble product in the form of a supernatant soln., (b) clarifying the supernatant by filtratition and subjecting it to ultrafiltration through a membrane with a mol. wt. cutoff threshold of 5000-35,000; and (c) adjust the filtrate to pH 4.5-6.0 and isolating the prod. Alternatively (and pref.) step (c) is carried out by (i) adjusting the filtrate to pH 2.1-3.4 and centrifuging to separate an acid-sensitive gel fraction and an acid-stable supernatant; (ii) adjusting the gel fraction to pH 9 with alkali and then to pH 3.5-6.9 with a cation exchanger; (iii) subjecting the supernatant from step (i), to thermal shock, removing insolubles and adjusting to pH 3.5-6.9 with alkali and (iv) combining the solns. with steps (ii) and (iii) and isolating the prod. The product is stated to be useful for treating inflammatory, degenerative and painful disorders of the skin, mucosa, blood vessels, connective and supportive tissues and organs, as well as metabolic regulatory disorders. It has higher antiinflammatory activity and lower toxicity than phenylbutazone.
The purpose of the present invention is to provide a mesoionic compound, which exhibits an improved controlling effect on various harmful organisms, or a salt thereof. A mesoionic compound represented by formula (1) (wherein: Ris selected from a hydrogen atom, etc.; Rrepresents an optionally substituted phenyl group; Ris selected from a hydrogen atom, etc.; Ris selected from a hydrogen atom, etc.; Ris selected from an optionally substituted ethylene group, etc.; and X is selected from an oxygen atom, etc.) or a salt thereof.
BACKGROUND: Aspiration pneumonia has a high recurrence rate, and oral care by dentists has been found effective in preventing its onset; however, this has not been evaluated using prospective studies. Therefore, we conducted a prospective study to evaluate the effectiveness of professional oral care by dentists in reducing aspiration pneumonia recurrence in older adult patients.
METHODS: In this prospective cohort study, we evaluated a dental oral care intervention, using a historical control group (control group). It was conducted at a single-centre regional core hospital in Japan that serves a large number of patients aged older than 80 years. Patients who were hospitalised for aspiration pneumonia were included in this study. During the study period (1 April 2021 to 31 March 2022), the clinical group received weekly professional cleaning by a dentist and the control group received standard oral care by a nurse as usual from 1 April 2020 to 31 March 2021. The dentist oral care group received weekly professional oral care from a dentist and was followed prospectively for 1 year. A Kaplan-Meier analysis was used to evaluate the timing of recurrent aspiration pneumonia or death. A Cox proportional hazards model was used to obtain a hazard ratio and determine the 95% confidence intervals.
RESULTS: There were 91 participants in the clinical group and 94 in the control group. The mean age of participants was 85 years, and 75 (40.5%) were female. The recurrence rate was 27.5% in the clinical group and 44.7% in the control group (P = .005). Professional cleaning by a dentist reduced the risk of recurrence of aspiration pneumonia by approximately 50% (adjusted hazard ratio, 0.465; 95% confidence interval, 0.278-0.78).
CONCLUSIONS: Professional cleaning by a dentist was associated with a lower rate of aspiration pneumonia recurrence than nurse-provided conventional oral care.
FIELD: medicine, hematology. SUBSTANCE: method involves dissolving gelatin in water, its thermic destruction in an aqueous solution and deionization on ion-exchange resins, gelatin hydrolysis, addition of sodium disubstituted hydrocitrate to solution, solution neutralization, addition of sodium chloride and sterilizing filtration. Before neutralization the sterilized adenine an aqueous solution is added to solution additionally at 50-60 C up to its concentration in preserving agent 0.30-0.45 g/l; also, sodium hydrogen phosphate is added to solution up to its concentration in preserving agent 3.5-4.5 g/l. Gelatin deionization is carried out on cation-exchange resins. EFFECT: enhanced effectiveness of preserving agent. 1 tbl
BACKGROUND: Post-operative pain control improves patient's satisfaction and affects the period of admission. Local wound infiltration following hernia surgery using xylocaine or bupivacaine has been a common practice. The use of tramadol for such infiltration is relatively new and has not been studied in our environment. This study compared the efficacy of post-operative pain control between Bupivacaine and Tramadol wound infiltration in children who underwent herniotomy and orchidopexy.
MATERIALS AND METHODS: This was a prospective randomised study involving 104 patients. A simple random method was used to allocate the study group into two equal groups (A, n = 52 and B, n = 52) using sealed envelopes with contents labelled A or B. Pre- and post-operative respiratory rate, heart rate, and C-reactive protein (CRP) were all recorded. Time to first and subsequent analgesia was determined using face, legs, activity, cry, consolability (FLACC) pain score.
RESULTS: Fifteen patients in Group A and 18 patients in Group B received each two doses of supplemental analgesia within the first 24 h, ( P = 0.527). Time to first analgesia was significantly different between the two groups, (6.93 ± 0.80 h and 6.11 ± 1.08 h, P = 0.020). The mean FLACC pain score at the time of first analgesia in hours was 4.93 ± 0.59 and 4.72 ± 0.67 for Group A and B, respectively, P = 0.350. The changes in CRP were not different in the two groups, ( P = 0.665). Four patients in Group A, but none in Group B had an episode each of post-operative vomiting.
CONCLUSION: Tramadol showed comparable efficacy with bupivacaine in post-operative pain control by wound infiltration in children who had unilateral herniotomy or orchidopexy. Tramadol, however, achieves a longer duration of action before rescue analgesic is required. Caution is necessary to avoid post-operative vomiting.
Crucial to designing anti-angiogenic and vascular targeting approaches is the identification of specific target molecules. We compared transcriptional profiles of tumor endothelial cells with that of normal resting endothelial cells, normal but angiogenically activated placental endothelial cells, and cultured endothelial cells. Although the majority of transcripts were classified as general angiogenesis markers, we identified 17 genes that show specific overexpression in tumor endothelium. Antibody targeting of four cell-surface expressed or secreted products (vimentin, CD59, HMGB1 and IGFBP7) inhibited angiogenesis in vitro and in vivo. Finally, targeting endothelial vimentin in a mouse tumor model significantly inhibited tumor growth and reduced microvessel density. Our results demonstrate the utility of the identification and subsequent targeting of specific tumor endothelial markers for anticancer therapy.
Tizanidine Tablets, USP is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. In patients with renal insufficiency (creatinine clearance < 25 mL/min) clearance was reduced by more than 50%. In these patients, during titration, the individual doses should be reduced. If higher doses are required, individual doses rather than dosing frequency should be increased. These patients should be monitored closely for the onset or increase in severity of the common adverse events (dry mouth, somnolence, asthenia and dizziness) as indicators of potential overdose. [see Dosage and Administration (Error! Hyperlink reference not valid.), Warnings and Precautions (Error! Hyperlink reference not valid.) and Clinical Pharmacology (12.3)]
Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membrane oxygenation can also lead to high death rate and need more technique and conditions. Mechanical ventilation with higher parameters was a substitute for such situations, but the death rate, complications and injuries of higher parameters is unknown. The purpose of the present study was to compare HFOV with CMV as invasive respiratory support strategies on decrease the mortality and morbidities in neonate with ARDS.
A system and method for monitoring a product inventory utilized in a blood component collection facility for collection at least one blood component from a donor is disclosed. The blood component collection facility includes a blood component collection instrument capable of being adapted to the donor wherein an operator facilitates interaction of the donor with the blood component collection facility. The system includes a system server having a blood component collection process. A product inventory database is provided for tracking various different inventory aspects of the blood component collection process. The product inventory represents a quantity of a product being available for use within the blood component collection facility. An interface being operably connected to the system servrt includes a reader for entering a blood component collection facility identifier, i.e., a product identifier. A web browser embedded within the interfact cooperates with an inventory web page for providing access to the inventory database wherein the product inventory can be monitored.
NSAIDs, including aspirin, a component of Orphenadrine Citrate Aspirin Caffeine Regular and Forte Tablets, can cause serious skin adverse reactions such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. NSAIDs can also cause fixed drug eruption (FDE). FDE may present as a more severe variant known as generalized bullous fixed drug eruption (GBFDE), which can be life-threatening. These serious events may occur without warning. Inform patients about the signs and symptoms of serious skin reactions, and to discontinue the use of Orphenadrine Citrate Aspirin Caffeine Regular and Forte Tablets at the first appearance of skin rash or any other sign of hypersensitivity. Orphenadrine Citrate Aspirin Caffeine Regular and Forte Tablets is contraindicated in patients with previous serious skin reactions to NSAIDs [see Contraindications:].
A role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple studies have demonstrated the potential involvement of several groups of cytokines and chemokines in acute and chronic HF, though targeting these pathways in early therapeutic trials have produced mixed results. These studies served to highlight the complexity and nuances of how pro-inflammatory pathways contribute to the pathogenesis of HF. More recent investigations have highlighted how inflammation may play distinct roles based on HF syndrome phenotypes, findings that may guide the development of novel therapies. In this review, we propose a contemporary update on the role of inflammation mediated by the innate and adaptive immune systems with HF, highlighting differences that exist across the ejection fraction spectrum. This will specifically be looked at through the lens of established and novel biomarkers of inflammation. Subsequently, we review how improvements in inflammatory pathways may mediate clinical benefits of existing guideline-directed medical therapies for HF, as well as future therapies in the pipeline targeting HF and inflammation.
Quantifying grip and grip movement is essential as it allows for a basis in upper limb functionality. However, when there is access, it causes changes in the hands and changes the motor in relation to the force and range of motion, or generates changes in activities of daily living. Thus, a system with 5 devices, where each one the devices were prints in three-dimensional, and instrumented with force sensor for static-dynamic force analysis e potentiometer for analysis range of motion, during the execution of movements cylindrical grip, spherical grip, hook grip, pulp-pulp pinch, and pulp- side pinch in different activities of daily living. Elaborated a data storage interface through MATLAB® software that allows recording the data of each device. For the system functionality tests, 30 volunteers were selected for both sexes, young adults between 20 and 39 years old, students of the Physiotherapy and Graduate courses of the University of Mogi das Cruzes. The tests are divided into two sessions and are repeated after 7 days of the first test
The invention relates to a natural marine extract composition and belongs to the technical field of daily cosmetics. In particular, the invention provides a skin care composition having anti-aging effect and based on marine extracts and a preparation method thereof. The marine extract composition includes 0.01-10% of glycoprotein extracted from deep-sea bacterial strain, 0.01-10% of an extract from distant sea phytoplanktons, and 0.01-10% of deep-sea crater thurmus fermentation active components. According to the invention, by means of the synergistic effect of the components, a significant synergism on anti-wrinkling and anti-aging effect is achieved. The composition can effectively scavenge free radicals, can significantly improve skin and increase skin elasticity, and can improve the proliferation capability of skin. The composition is excellent in compatibility of human body and is easier to absorb by human body, is excellent in promotion effect on growth of skin cells, can accelerate cell metabolism and can enhance skin cell vitality.
BACKGROUND: Randomized controlled trials (RCTs) have shown varying results between immediate and staged complete percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and multivessel disease (MVD). We conducted a meta-analysis to reconcile the findings.
METHODS: Online databases were searched for RCTs comparing immediate vs staged complete PCI in patients presenting with ACS. The outcomes of interest were major adverse cardiovascular events (MACE), all cause death, myocardial infarction (MI), cardiovascular death, stent thrombosis, target vessel revascularization (TVR), cerebrovascular events, bleeding and acute kidney injury (AKI)/contrast induced nephropathy (CIN). Risk ratios (RR) with 95 % confidence intervals (CI) were calculated using the random-effects model.
RESULTS: Nine RCTs with a total of 3637 patients - 1821 in the immediate PCI group and 1816 in the staged PCI group, were included. The mean age was 64 years, 78 % of patients were men and the mean duration of follow up was 1 year. As compared with staged complete PCI, the immediate PCI group was associated with significant reduction of MI (RR 0.53, 95 % CI 0.36-0.77) and TVR (RR 0.69, 95 % CI 0.53-0.90). The risks of all-cause death, cardiovascular death, MACE, cerebrovascular events, stent thrombosis, bleeding and AKI/CIN were similar in the two groups.
CONCLUSIONS: In ACS patients selected for complete revascularization strategy, multivessel PCI during the index procedure may be associated with significant reduction in the risk of MI and TVR without harm when compared with a staged PCI strategy.
In this group, caretakers of children will receive the standard advice under current iCCM guidelines in DRC. Specifically, the CHW will advise that the child come back in 2-3 days.
The implant pockets will be debrided with the BioClean™ biodegradable brush for 2 minutes and with the brush seated in an oscillating dental handpiece (NSK ESQ10 TEQ) and thereafter irrigated two minutes with tetracycline-hydrochloride (Arco Interpharma AS, Hokksund, Norway) in sterile saline with a concentration of 150 mg/ml, as chemical detergent adjunct to the chitosan brush. The treatment will be repeated every three months. Debridement is performed with local anaesthesia as needed.
The phenotype of circulating tumor cells (CTCs) offers valuable insights into monitoring cancer metastasis and recurrence. While microfluidics presents a promising approach for capturing these rare cells in blood, the phenotypic profiling of CTCs remains technically challenging. Herein, we developed a nanoporous micropillar array chip enabling highly efficient capture and in situ phenotypic analysis of CTCs through enhanced and tunable on-chip immunoaffinity binding. The nanoporous micropillar array addresses the fundamental limits in fluidic mass transfer, surface stagnant flow boundary effect, and interface topographic and multivalent reactions simultaneously within a single device, resulting in a synergistic enhancement of CTC immunocapture efficiency. The CTC capture efficiency increased by approximately 40% for cancer cells with low surface marker expressing. By manipulating fluidic velocity (hydrodynamic drag force) on the chip, a cell adhesion gradient was generated in the capture chamber, enabling individual CTCs with varying expression levels of epithelial cellular adhesion molecules to be immunocaptured at the corresponding spatial locations where equilibrium drag force is provided. The clinical utility of the nanoporous micropillar array was demonstrated by accurately distinguishing early and advanced stages of breast cancer and further longitudinally monitoring treatment response. We envision that the nanoporous micropillar array chip will provide an in situ capture and molecular profiling approach for CTCs and enhance the clinical application of CTC liquid biopsy.
Obesity confers risk for cardiovascular disease and vascular dementia. However, genomic alterations modulated by obesity in endothelial cells in the brain and their relationship to other neurovascular unit (NVU) cells are unknown. We performed single nuclei RNA sequencing (snRNAseq) of the NVU (endothelial cells, astrocytes, microglia, and neurons) from the hippocampus of obese (ob/ob) and wild-type (WT) male mice to characterize obesity-induced transcriptomic changes in a key brain memory center and assessed blood-brain barrier permeability (BBB) by gadolinium-enhanced magnetic resonance imaging (MRI). Ob/ob mice displayed obesity, hyperinsulinemia, and impaired glucose tolerance. snRNAseq profiled 14 distinct cell types and 32 clusters within the hippocampus of ob/ob and WT mice and uncovered differentially expressed genes (DEGs) in all NVU cell types, namely, 4462 in neurons, 1386 in astrocytes, 125 in endothelial cells, and 154 in microglia. Gene ontology analysis identified important biological processes such as angiogenesis in endothelial cells and synaptic trafficking in neurons. Cellular pathway analysis included focal adhesion and insulin signaling, which were common to all NVU cell types. Correlation analysis revealed significant positive correlations between endothelial cells and other NVU cell types. Differentially expressed long non-coding RNAs (lncRNAs) were observed in cells of the NVU-affecting pathways such as TNF and mTOR. BBB permeability showed a trend toward increased signal intensity in ob/ob mice. Taken together, our study provides in-depth insight into the molecular mechanisms underlying cognitive dysfunction in obesity and may have implications for therapeutic gene targeting.
Systems and methods are provided for managing medical devices. In one embodiment, medical device usage data is stored on the medical device to indicate the usage, health, and alarm or error codes. The usage data is electronically read and assessed against one or more thresholds to determine if the medical device is operating properly and, hence, can be inventoried for reuse, or is need of service or repair. Other embodiments are also disclosed wherein the medical device wirelessly scan its environment to ensure, for example, the device is used with approved accessories or components and personnel. In yet other embodiments, medical devices are provided that can configure themselves for operation by scanning any connected components for component-specific operational data. The operational data is then used to configure the medical device to operate with the component.
Participants undergo onsite gentle yoga once weekly over 45-60 minutes for 8 weeks and home-based gentle yoga for 6 weeks. Participants also undergo dietary counseling over 8 weeks.