anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To provide a makeup cosmetic applicable smoothly to the skin giving durable and smooth film, having moisturizing effect and free from irritation to the skin, by compounding a cosmetic base with a pigment or extender pigment surface-treated with hydrogenated lecithin. CONSTITUTION:The surface of an inorganic pigment such as titanium oxide, red oxide, yellow oxide, etc. to an extender pigment such as talc, kaolin, mica, etc. is treated with hydrogenated lecithin having an iodine value of <=30 and prepared by the hydrogenation of natural or synthetic lecithin, and the obtained treated pigment is compound to a cosmetic base. For example, an aqueous dispersion of pigment is added with 0.3-10% hydrogenated lecithin based on the pigment, and heated under vigorous agitation to effect the complete dissolution or emulsification of the hydrogenated lecithin in water and the adsorption of the lecithin to the surface of the pigment particle. An aqueous solution of a soluble salt of Al, Mg, Ca, etc. is added dropwise to the mixture in an amount of 0.1- 2 equivalent based on the lecithin. A water-insoluble salt of lecithin and the above metal is formed and is completely oriented and adsorbed on the surface of the pigment.
The present invention discloses a kind of preparation method for the 3D printing method and membrane material for nursing film, including, A. scanning nursing position；B. data processing；C. the counterdie consistent with nursing feature is made；D. membrane material is sent into 3D printer, thin film is printed on counterdie；E. basic nursing composition is sprayed to film general duty nursing position to film surface, and vacates film special care region；F. the special care region sequentially vacated respectively to film sequentially sprays corresponding nursing composition respectively；G. individual nursing film finished product.Beneficial effect is：Nursing film can be bonded completely with personal characteristics completely, and need to add different compositions according to different parts, the defects of overcoming single film single effect, meet the individual character needs of people；Other membrane material selects most light most soft most thin natural fiber silk in nature, but changes the form of existing silk braiding film forming, is changed to pulpous state printed matter, individual nursing film is met multi-party demand.
<P>PROBLEM TO BE SOLVED: To provide a method of dividing a tablet, a method of facilitating division of a tablet, and a method of manufacturing easily dividable tablets, especially using a dividable tablet which can be easily and accurately dividable, having superior impact resistance without generating chipping and, having a shape by which tablets produces no mutual twinning or the like in a film coating process.  <P>SOLUTION: The dividable tablet has an upper surface, a lower surface, and the edge portion therebetween. On the upper surface of the tablet, in each of two areas formed by a dividing line formed along the center line, ridge lines are formed so as to surround the dividing line and be positioned inward from the edge portion of the tablet. The lower surface of the tablet gradually rises from the edge portion of the tablet toward the center part, and areas around the two ridge lines are each formed by a convex surface, and a surfaces from the dividing line to the two ridge lines are each formed of convex surfaces. A press-through pack is held in a condition a storing recess part is upward directed, and then the dividable tablet is divided by pushing the convex part to be an outer part from above.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
PURPOSE:To measure human interleukin-2 antibody with high sensitivity by using the anti-recombinant type human interleukin-2 antibody originating in a warm-blooded animal or the fragment thereof as antibodies in an enzyme immunological measurement method of a sandwich method. CONSTITUTION:The anti-recombinant type human interleukin-2 antibody (rIL-2) originating in the warm-blooded animal or the fragment thereof is used for the antibody to be held on a carrier or the fragment thereof. The recombinant type human interleukin-2 (IL-2) is used as an antigen and is inoculated to the warm-blooded animal, for example, rabbit, goat, etc., to obtain the antibody rIL-2. A peroxidase, etc., are used as a labeling agent. The antibody rIL-2 and the labeled antibody rIL-2 are added to the serum to be inspected and after the serum is preserved for the prescribed time at a prescribed temp., the absorbancy thereof is measured and is fitted to a preliminarily made standard curve to calculate the concn. of the antibody rIL-2. Since the anti-recombinant type antibody rIL-2 originating in the warm-blooded animal is used, IL-2 is exactly measured as protein and a slight amt. of IL-2 is made measurable in a clinical inspection.
The mechanisms of obesity are complex, involved in genes, environment, life style, and systemic and adipose tissue inflammation. Dysbiosis of gut microbiome is considered to make a difference in obesity. On the other hand, both long-term and short-term dietary interventions can induce changes in the body composition and structure and function of gut microbiome. However, it is not really clear how gut microbiome changes along with weight loss in overweight or obese.

In the present study, investigators aim to characterize the gut microbiome among overweight or obese participants on a modified Atkins diets. The stool and blood samples were collected by an interval of every 5% and 10% of weight loss, respectively. Data collecting mainly covers: 1) body composition analysis ; 2) obesity related biochemical metabolism; 3) measurement of gut microbiome using metagenome and 16S rRNA sequencing techniques; 4) metabolomics of serum and gut microbiome; 5) measurement of physical activity and diets using questionnaires.
Studies have reported that Prosaposin (PSAP) is neuroprotective in cerebrovascular diseases. We hypothesized that PSAP would reduce infarct volume by attenuating neuronal apoptosis and promoting cell survival through G protein-coupled receptor 37(GPR37)/PI3K/Akt/ASK1 pathway in middle cerebral artery occlusion (MCAO) rats. Two hundred and thirty-five male and eighteen female Sprague-Dawley rats were used. Recombinant human PSAP (rPSAP) was administered intranasally 1 h (h) after reperfusion. PSAP small interfering ribonucleic acid (siRNA), GPR37 siRNA, and PI3K specific inhibitor LY294002 were administered intracerebroventricularly 48 h before MCAO. Infarct volume, neurological score, immunofluorescence staining, Western blot, Fluoro-Jade C (FJC) and TUNEL staining were examined. The expression of endogenous PSAP and GPR37 were increased after MCAO. Intranasal administration of rPSAP reduced brain infarction, neuronal apoptosis, and improved both short- and long-term neurological function. Knockdown of endogenous PSAP aggravated neurological deficits. Treatment with exogenous rPSAP increased PI3K expression, Akt and ASK1 phosphorylation, and Bcl-2 expression; phosphorylated-JNK and Bax levels were reduced along with the number of FJC and TUNEL positive neurons. GPR37 siRNA and LY294002 abolished the anti-apoptotic effect of rPSAP at 24 h after MCAO. In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.
Myofascial release, also known as fascial release or fascial manipulation, is a physical therapy used to treat muscle and fascial tissue tension or pain. It involves applying appropriate pressure and stretching to release tight fascia and soft tissues, improving blood circulation, alleviating pain, and promoting rehabilitation. The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Traumatic Brain injured Survivors. The main question it aims to answer is:

• Can Myofascial Release Therapy improve swallowing function in Traumatic Brain injured Survivors? Patients will be randomly allocated into the control group or the experimental group, all under rehabilitation treatment, the experimental group will be given Myofascial Release Therapy. The study lasts 21 days for each patient. Researchers will compare the Functional Oral Intake Scale, Penetration-Aspiration Scale, Swallowing Quality of Life to see if the Myofascial Release Therapy can help improve the situation.
Several neural mobilization techniques will be performed for the lower limb, with a special focus on the sciatic nerve. First, three different passive techniques will be used. These will consist of two sets of ten repetitions each with one minute rest between sets. This will last approximately 5 minutes. Then, three dynamic neural mobilization techniques will be performed, with each exercise lasting for 5 minutes per set, including two different sets (one minute rest between them), with a total of 10 minutes of mobilization and one minute of rest per exercise. Therefore the complete approach will last for 30 minutes approximately. Following this set of dynamic neural mobilization exercises, static neural mobilizations of the sciatic nerve will be performed again following the same order and duration than in the beginning.
Novel or rare damaging mutations have been implicated in the developmental pathogenesis of nonsyndromic cleft lip with or without cleft palate (nsCL ± P). Thus, we investigated the human genome for high-impact mutations that could explain the risk of nsCL ± P in our cohorts. We conducted next-generation sequencing (NGS) analysis of 130 nsCL ± P case-parent African trios to identify pathogenic variants that contribute to the risk of clefting. We replicated this analysis using whole-exome sequence data from a Brazilian nsCL ± P cohort. Computational analyses were then used to predict the mechanism by which these variants could result in increased risks for nsCL ± P. We discovered damaging mutations within the AFDN gene, a cell adhesion molecule (CAMs) that was previously shown to contribute to cleft palate in mice. These mutations include p.Met1164Ile, p.Thr453Asn, p.Pro1638Ala, p.Arg669Gln, p.Ala1717Val, and p.Arg1596His. We also discovered a novel splicing p.Leu1588Leu mutation in this protein. Computational analysis suggests that these amino acid changes affect the interactions with other cleft-associated genes including nectins (PVRL1, PVRL2, PVRL3, and PVRL4) CDH1, CTNNA1, and CTNND1. This is the first report on the contribution of AFDN to the risk for nsCL ± P in humans. AFDN encodes AFADIN, an important CAM that forms calcium-independent complexes with nectins 1 and 4 (encoded by the genes PVRL1 and PVRL4). This discovery shows the power of NGS analysis of multiethnic cleft samples in combination with a computational approach in the understanding of the pathogenesis of nsCL ± P.
1342761 Whole eye extract "BIOFARM" FABRICA DE MEDICAMENTE 8 April 1971 9098/71 Heading ASB A whole eye extract is prepared from bovine eyes by removing adherent tissues from the eyeballs, washing the eyeballs with a dilute aqueous solution of alkali metal merthiolate, followed by autolysis of 0‹ to +4‹C., hashing the autolysed eyeballs, extracting the hash with alcohol, filtering the extract thus obtained, concentrating and drying the alcoholic extract, redissolving the dried extract in water and standardising the solution. Preferably the alcoholic extraction is carried out with 2 ml of rectified alcohol for every gram of eye hash, the extraction being performed first with mechanical agitation followed by a rest period of 24 hours. The alcoholic extract is filtered in a first stage in a press and then through a dense cloth, the filtration being repeated 4 or 5 times through filter paper. Concentration of he extract is performed under vacuum at a temperature not above 52‹C for the removal of alcohol and of part of the water to give a paste-like consistency, then by mixing the concentrate with 10% of purified diatomaceous earth and maintenance at 90‹-100‹C to complete dryness, finally removing the remaining water in a desiccator in the presence of solid absorbents. Following this, the dry extract, tested for the presence of albumin, is dissolved in water in several stages in the course of which the sediment is separated by centrifugation for the complete removal of diatomaceous earth and finally the extract is standardised such that one milli litre of the final extract is the equivalent of one gram of hash. The whole eye extract is employed in the ophthalmological therapy for the treatment of myopic chorio-retinitis, ocular astenopia, vitreous body opacities, iritis and iridocyclitis and corneal ulcerations and may be administered by sub-conjunctival and/or subcutaneous injection.
The purpose is to compare the efficacy of ranibizumab versus additional panretinal photocoagulation on diabetic neovascularization that is persistent despite previous treatment with panretinal photocoagulation. We hypothesize that ranibizumab intravitreal injections would induce neovascular regression in similar or better fashion than supplemental laser photocoagulation. Consented, enrolled subjects will either receive open-label intravitreal injections of 0.5-mg dose of ranibizumab or additional panretinal photocoagulation (up to 500 300-500 um laser spots) in a ratio of two-to-one (2:1) at the beginning of the study period. ETDRS best-corrected visual acuity, contrast sensitivity, and Optos color photography will be performed at enrollment, at weeks 1, 2, 3 and 4, and at months 2, 3, 4, 5 and 6. The subjects will undergo fluorescein angiography utilizing the Optomap FA (fluorescein angiography) system and optical coherence tomography (OCT) at enrollment, at weeks 2 and 4, and at months 2, 3, 4 and 6. The subjects will be followed for a 6-month period for stabilization, regression, or recurrence of neovascularization. In addition, patients will be evaluated for occurrence of macular edema.
<P>PROBLEM TO BE SOLVED: To partly clear the mechanism of the generation of dark circles around the eye and provide a cosmetic product to ameliorate the dark circles.  <P>SOLUTION: The skin care preparation to be applied mainly to the dent part under the eye contains 5-15 mass% ascorbic acid and/or its salt. The skin care preparation has uniformizing action on the skin thickness and the blood flow rate. The uniformizing action on the skin thickness and blood flow rate is recognized as the amelioration action on dark circles. The variations of the values are determined on an examinee and compared with average variations of a specimen group, and the examinee is selected as a proper person to test the preparation when the variations of the examinee are larger than the average variations.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This project has been launched after the introduction of Altis in Europe. This study is a multicenter prospective, observational (i.e. naturalistic) post-marketing clinical follow-up of women for who stress urinary incontinence was diagnosed and will be treated with Altis Single Incision Sling System. Therefore these patients will be asked to allow to use their clinical data and answer some questionnaires. The patients'data will be collected in routine clinical practice before, during and after surgery until 12 months. Then, questionnaires will be mailed to the participants annually during 2 additional years.
Participants applied Cellegesic 375 mg ointment containing approximately 1.5 mg of nitroglycerin anally twice daily for 21 days. In addition, participants took acetaminophen 650 mg orally twice daily for 21 days.
A method of identifying one or more suitable epigenetic editing target sites in a target cell is described herein. The method may include providing a first epigenetic map of a target cell in an initial cellular state. The first epigenetic map may provide an epigenetic state of each genomic site of a plurality of genomic sites in the target cell. The method may include providing a second epigenetic map of a desired cell in a desired cellular state. The second epigenetic map may provide an epigenetic state of each genomic site of the plurality of genomic sites in the desired cell. The method may include comparing the first epigenetic map and the second epigenetic map, thereby detecting a first differential. The method may include identifying a target genomic site in the plurality of genomic sites using the first differential. The target genomic site may be in an initial epigenetic state in the target cell and in a desired epigenetic state in the desired cell, wherein the initial epigenetic state and the desired epigenetic state are different epigenetic states.
This arm describes some aspects of ventilation during anesthesia for laparoscopic gastric bypass. Pre-oxygenation is with a FIO2 of 1.0, supplied by a continuous positive airway pressure of 10 cmH2O, during anesthesia a positive end-expiratory pressure of 10 cmH2O is used and during emergence from anesthesia a FIO2 of 0.3 is used. The intervention associated with this arm is labeled CPAP and 31% oxygen.
Total knee arthroplasty(TKA) is mostly performed with tourniquet applied, because it allows decreased intraoperative blood loss, better visualization of surgical field and better cement fixation of the implants, compared to the TKA without using tourniquet. However, there remains a controversy about the timing of tourniquet release, so the tourniquet may be unreleased throughout the whole operation time or released early just after cement fixation of the implants, atc. Early tourniquet release is generally aimed to control hidden arterial bleeding which would not be revealed if the tourniquet was unreleased. This method was reported to reduce arterial bleeding and its related complications, but it was also known that increase intraoperative bleeding, incidence of transfusion, and operation time. On the other hand, late tourniquet release, which the tourniquet is unreleased until the wound is closed, is reported to increase tourniquet-use time and related complications owing to longer tourniquet time, although it gives shorter operation time. The investigators have been used a way of reinflation of tourniquet after early release, once the arterial bleeding was controlled sufficiently, to balance the advantages and disadvantages of the early tourniquet release. The investigators were able to control arterial bleeding during the time the tourniquet was released, and the remained procedures were performed conveniently with good visualization of the surgical field after the tourniquet was reinflated again. However, there was no previous studies about the efficacy and the safety of the way of reinflation after early release of the tourniquet in the literature. Therefore, the investigators ask in this study whether the reinflation after early tourniquet release has advantages over the method of early tourniquet release without reinflation, in terms of efficacy and safety.
A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. Alternatively, the gas can be injected such that it remains as a gas in the bloodstream for a period of time (such as about 8-29 seconds). The injectable formulation of polarized 129Xe gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized 129Xe and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. One method injects the polarized 129Xe as a gas into a vein and also directs another quantity of polarized gas into the subject via inhalation. In this embodiment, the perfusion uptake allows arterial signal information and the injection (venous side) allows venous signal information. The dual delivery is used to generate a combined introduction path with a more complete image signal of both the arterial and venous side of the pulmonary vasculature. In this NMR imaging method, the pulmonary embolism screening method can use the same NMR chest coil for the excitation and detection of the 129Xe signals. The direct injection of small quantities of gas at particular sites along the vasculature targets specific target regions to provide increased signal intensity NMR images. The disclosure also includes related methods directed to other diagnostic vasculature regions physiological and conditions. Associated delivery and dispensing systems and methods, containers, and quantitative formulations of the polarized gas are also described.
Azithromycin tablets and oral suspension can be taken with or without food.

Patients should also be cautioned not to take aluminum- and magnesium-containing antacids and azithromycin simultaneously.

The patient should be directed to discontinue azithromycin immediately and contact a physician if any signs of an allergic reaction occur.

Patients should be counseled that antibacterial drugs including azithromycin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When azithromycin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of the therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by azithromycin or other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.
The invention relates to a pillow capable of alleviating fatigue, characterized by comprising a pillow outer skin (1), the outer skin is sequentially composed of a 0.5-1cm thick sponge layer (2), a pillow inner layer skin (3) and uniformly mixed medicines (4) covered by the inner layer skin of the pillow. The pillow has the following beneficial effects: camphora leaves contain little camphor capable of stimulating the central nervous system. Mint leaves can refresh head and eyes, sooth the liver, alleviate mental depression and stimulate the central nervous system. Bamboo leaves can clear heat and relieve fidget, and be diuretic and can promote the production of body fluid. Chinese mugwort leaves are capable of regulating the flow of vital energy and the blood and eliminating cold and dampness. Fruit of Japanese Metaplexis has functions of benefiting vital essence and promoting tissue regeneration, and floccules attached to the Fruit of Japanese Metaplexis have soft elasticity so as to be suitable for making the pillow. The pillow has the following advantages: the pillow can both alleviate fatigue and be used as a normal pillow, and also can refresh head and spirits.
Peer Support Workers (PSWs) hold 1-2 meetings with clients (30-60 minutes) in the 2-week period before they are discharged from hospital. They describe the program and undertake an assessment. From this assessment the two core components of the intervention are initiated. First, a "welcome basket" is created for the client. The PSW also forms a plan with the client about tours of their neighbourhood to familiarize them with the local resources and support them in building confidence in accessing their local communities. These activities will take place through weekly visits (2 hours/visit) in the 4 weeks immediately following discharge. WB will be provided in combination with core Cognitive Adaptation Training (CAT) compensatory interventions.