anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A compound of formula (I), where: X is hydrogen, -OH, a linear, branched or cyclic alkyl, alkenyl or alkynyl radical optionally interrupted by oxygen, nitrogen or sulfur atoms and optionally substituted with halogen, heterocycle, free or esterified -OH, -CºN, -NO2; or X is alkoxy, NRcRd, or a group of formula (II) or formula (III). Y is oxygen, =N-Nalk1 or =NOalk2, where alk1 and alk2 are alkyl optionally interrupted by oxygen, sulfur or nitrogen atoms and optionally substituted with halogen, aryl optionally substituted with halogen, heterocyclic or a group of formula (II). Z is hydrogen, halogen, or a free, etherified or esterified OH radical. R is hydrogen or alkyl R1 is hydrogen, a linear, branched or cyclic alkyl, alkenyl or alkynyl radical optionally substituted by halogen, -CºN or aryl. R2 is hydrogen or halogen. R3 is hydrogen, halogen or alkyl R5 is hydrogen or alkoxy. R6 is ethenyl, propenyl, alkyl or -CH2-O-alkyl and R7 is hydrogen or alkyl; or R6 and R7 together with the carbon to which they are attached form a ring. Also described is a medicament comprising the compound of formula (I) and a pharmaceutical composition thereof comprising this medicament. Also described is a compound of formula (IV), where: Z, R2, R3, and R5-R7 are as defined for the compound of formula (I). OW is a blocked hydroxy group. W' is alkyl or alkoxy.
Patients with probable Alzheimer's disease according with the NINDS-ADRDA and DSM-IV diagnostic criteria. An additional criterion is a MMSE score between 16 and 27. All AD patients must have capacity to provide informed consent as judged by the referring physician.
Nitric oxide is an important molecule for human health because it controls blood flow and blood pressure. With aging, our ability to make nitric oxide gets worse and our blood pressure tends to increase. We can help the body produce more nitric oxide by supplementing the diet with vegetables, such as beetroot juice, which contains high amounts of nitrate. This has been shown to improve blood flow and blood pressure. The bacteria inside our mouths play an important role in helping convert the ingested nitrate to nitric oxide. The reason for this study is to find out whether there are differences in oral bacteria between young and older adults, and how the oral bacterial community and blood flow and blood pressure might change when diet is supplemented with natural, nitrate-rich beetroot juice and when we use antibacterial mouthwash. This study will help us understand how the bacteria inside our mouths might be useful for keeping us healthy.
Glaucoma is the leading cause of irreversible blindness worldwide, and its treatment consists of lowering intraocular pressure to prevent damage to the optic nerve and loss of vision\[1\]. Current methods for lowering intraocular pressure (IOP) include topical and oral medications, laser trabeculoplasty, microincisional glaucoma surgery (MIGS), and traditional incisional surgeries such as trabeculectomy and aqueous tube shunts. MIGS have become more popular in recent years as less invasive methods than traditional surgeries that effectively reduce IOP and help reduce the medication burden on patients\[1\]. There are multiple available MIGS procedures, most of which act by increasing trabecular outflow. One such procedure is the goniotomy via Kahook Dual Blade (KDB), which is usually performed in combination with cataract surgery. KDB is an FDA approved device used to perform a goniotomy via an internal approach. Strips of the nasal angle trabecular meshwork are removed providing a direct pathway for aqueous outflow from the anterior chamber into the collector channels\[2\].

Pilocarpine, a parasympathomimetic agent, is a glaucoma medication that works by causing contraction of the ciliary muscle leading to opening of the trabecular meshwork\[3\]. Due to its frequent dosing requirement and large number of ocular and systemic side effects, pilocarpine has largely fallen out of favor for the treatment of primary open angle glaucoma (POAG), except in patients for whom few other alternatives exist. However, pilocarpine is often used after goniotomy surgery. The rational for its use after goniotomy procedure is for its miotic effect, which theoretically may prevent the formation of peripheral anterior synechiae. Formation of peripheral anterior synechiae can lead to the closure of the cleft that is generated and the possibility of failure of the procedure. While the theoretical benefit of pilocarpine has been proposed, its actual benefit has never been proven. This study will evaluate whether goniotomy via KDB / Cataract surgery without pilocarpine is non-inferior to the same surgery procedure followed by treatment with pilocarpine.
Nurse-Led Coordinated Physical Activity Program for Child Health, consisting of nurse, teacher, and family components was implemented by the researcher two days a week for six weeks. The interventions were last an average of 60 minutes each week. During this time, the nurse implemented a program, developed based on expert opinion and various guidelines, that directed students to be more active. Teachers were expected to encourage students and actively participate in the program. Families were regularly informed through the "family bulletin" and it was ensured that the program started at school was continued at home.
OBJECTIVES: There is an increase in stroke incidence risk over the lifetime of women, given their longer life expectancy. However, an alarming trend for sex disparities, particularly in certain stroke risk factors, shows a concerning need for focus on sex differences in stroke prevention and treatment for women. In this article, we are addressing sex differences in both traditional and sex-specific stroke risk factors.
METHODS: We searched PubMed from inception to December 2022 for articles related to sex differences and risk factors for stroke. We reviewed full-text articles for relevance and ultimately included 152 articles for this focused review.
RESULTS: Women are at increased risk for stroke from both traditional and non-traditional stroke risk factors. As women age, they have a higher disease burden of atrial fibrillation, increased risk of stroke related to diabetes, worsening lipid profiles, and higher prevalence of hypertension and obesity compared to men. Further, women carry sex hormone-specific risk factors for stroke, including the age of menarche, menopause, pregnancy, and its complications, as well as hormonal therapy. Men have a higher prevalence of tobacco use and atrial fibrillation, as well as an increased risk for stroke related to hyperlipidemia. Additionally, men have sex-specific risks related to low testosterone levels.
CONCLUSIONS: By identifying biological sex-specific risk factors for stroke, developing robust collaborations, researching, and applying the knowledge for risk reduction strategies, we can begin to tailor prevention and reduce the global burden of stroke morbidity and mortality.
Duct-to-mucosa and invagination pancreaticojejunostomy are two most commonly used anastomotic techniques after pancreaticoduodenectomy, with comparable incidence rate of pancreatic fistula (PF). We modified the conventional two-layer duct-to-mucosa PJ into one-layer PJ. The aim of this study is to examine if the investigator's modified duct-to-mucosa PJ can reduce PF after PD when compared to invagination PJ.

This trial is a single-center, randomized, controlled, patient- and observer- blinded study, whose primary aim is to assess whether a modified duct-to-mucosa PJ (trial group) is superior to an invagination PJ (control group), in terms of clinically relevant PF and other complications. A total of 380 patients, who are to undergo elective PD, will be recruited and randomized intraoperatively into either of the two groups. The primary efficacy endpoint is the incident rate of clinically relevant PF. Secondary outcome measures are: entry into adjuvant therapy, mortality, surgical complications, non-surgical complications, hospital stay. Patients will be followed up for 3 months. Statistical analysis will be based on the intention-to-treat population. The duration of the entire trial is estimated to be two years.
Desoximetasone Cream USP, 0.25% contains the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.

Each gram of Desoximetasone Cream USP, 0.25% contains 2.5 mg of desoximetasone in an emollient cream consisting of aluminum monostearate, cetostearyl alcohol, isopropyl myristate, lanolin alcohols, magnesium stearate, mineral oil, paraffin wax, purified water, and white petrolatum.

The chemical name of desoximetasone is Pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-,(11β,16α)-. Desoximetasone has the molecular formula C22H29FO4 and a molecular weight of 376.47. The CAS Registry Number is 382-67-2. The chemical structure is:
PURPOSE:To provide the titled cataplasm useful for the therapies for nicotine- toxic patients, made up of a tacky layer adhesive to the oral cavity mucous membrane and a nicotine-contg. substrate layer thereon. CONSTITUTION:Firstly, a tacky layer is prepared by dispersing a water-soluble polymer (e.g. polyvinyl alcohol) and water-insoluble polymer (e.g. ethyl cellulose) and/or water-swellable polymer with 1-50wt.% of nicotine or its salt and, if needed, organic acid and/or basic substance followed by pH adjustment. Thence, this tacky layer is made to adhere to a substrate layer adhesive to the oral cavity mucous membrane, thus obtaining the objective cataplasm. The contents of the respective polymers in the layers are as follows: (1) the water-soluble polymer: 20-80wt.% (in the tacky layer); (2) the water-swellable and/or water- insoluble polymer: 1-70wt.% (in the tacky layer) and 50-90wt.% (in the substrate layer). The present cataplasm can administer the nicotine to the oral cavity mucous membrane quantitatively and substainedly.
Patients allocated to the intervention group will receive an email with a link to a video and a pdf document. The video and the pdf document will introduce them to the principles and the practice of mindfulness. They will also receive an access code to an e-tool valid for 1 month. On this e-tool the patient will have access to short guided meditations both general and specific to infertility. They will be instructed to follow the "découverte" (discovery) program of 8 meditations of 10 minutes and then the program "désir de parentalité (wish to become a parent) of 13 minutes 15 meditations of 13 minutes each. Patients will be given access to all other meditations programs of PetitBambou and instructed to meditate with the program for at least 10-15 minutes on a daily basis.
<P>PROBLEM TO BE SOLVED: To provide a stable polypeptide which is capable of inducing the production of interferon-gamma in an immunocompetent cell.  <P>SOLUTION: The polypeptide includes a specific amino acid sequence, and induces the production of interferon-gamma in the immunocompetent cell. The the DNA encodes the polypeptide. The the method for producing the polypeptide comprises a process culturing a transformant obtained by transducing a DNA encoding the polypeptide in an appropriate host, and a process collecting the product polypeptide from the culture. The medicament for anti-sensitive disease contains the polypeptide as an active ingredient.  <P>COPYRIGHT: (C)2007,JPO&INPIT
PROBLEM TO BE SOLVED: To obtain a perfume composition excellent in long-lasting perfume by incorporating a benzylcyclohexanol represented by a specific formula. SOLUTION: Morpholine is dissolved in a solvent, e.g. toluene, and 3- phenylpropionaldehyde is dropped thereinto with ice-cooling. The solution is subjected to azeotropic dehydration to remove unreacted substances. Subsequently, methyl vinyl ketone is added to the solution, and the resulting reaction product is mixed with p-toluenesulfonic acid in a solvent. This mixture is subjected to azeotropic dehydration and then neutralized to obtain 4-benzyl-2- cyclohexen-1-one. This reaction product is hydrogenated in methanol with the aid of a Raney nickel catalyst to obtain a mixture of the cis and trans isomers of the benzylcyclohexanol (a) represented by the formula (wherein the part indicated with the broken line may be a double bond, and the benzyl group is located in the 2-, 3-, or 4-position to the hydroxyl group).  Alternatively, the reaction product is reduced in an ether with LiAlH4 to obtain 4-benzyl-2- cyclohexen-1-ol (b). 0.5-70wt.% the compound (a) or (b) is incorporated to obtain the objective composition.
INTRODUCTION: High tibial osteotomy (HTO) is a surgery performed to treat the symptoms and prevent the progression of medial osteoarthritis. Post-operative bleeding has led to early returns to hospital following surgery. Intrafocal injection of tranexamic acid (TXA) could reduce this bleeding complication. The objective of the study was to evaluate the effect of TXA during HTO on the incidence of post-operative complications and early returns to hospital.
MATERIALS AND METHODS: This retrospective study included 251 cases of HTO performed between May 2012 and October 2021, with the use of TXA introduced in May 2017. The experimental (n = 102) and control (n = 149) groups were compared as to the rate of post-operative early returns. The influence of confounding factors was evaluated, including age, sex, body mass index (BMI), tobacco use, grade of medial femorotibial osteoarthritis (MFTO), magnitude of angular correction (MAC), and surgery duration.
RESULTS: No statistically significant difference was found between the groups with regards to all variables except age. The experimental group was significantly older (54.4 years; σ = 7.5) than the control group (50.4 years; σ = 7.9; p < 0.001). We observed a decrease in emergency department (ED) visits in the experimental group (15.7%) compared to the control (30.2%; p = 0.008) and a decrease in early returns in the experimental group (28.4%) compared to the control (40.5%; p = 0.049). No statistically significant difference in demographic data, MFTO, or MAC was found among patients with and without an early return, in both the experimental and control groups.
CONCLUSION: The intrafocal injection of TXA during HTO decreases early returns to hospital.
Hair or other keratinous fibre is dyed by applying an aqueous composition comprising 5 : 6-dihydroxyindole and ammonia, an ammonium salt or an amine.  The dihydroxyindole may be formed in situ by the hydrolysis of 5 : 6-diacetoxyindole.  Specified ammonium salts are ammonium carbonate and triammonium phosphate, specified amines being mono- or triethanolamine, morpholine, hydrazine, diethylamine and hydroxylamine.  The composition may also include oxidizing agents such as sodium-bromate, -perborate or -percarbonate, ammonium persulphate and hydrogen peroxide. Oxidation catalysts such as manganese-sulphate or -lactate, cobalt chloride, ferric chloride, cupric chloride and ammoniacal silver nitrate, may be added to the composition or applied to the hair as a subsequent treatment. Reducing agents e.g. thioglycollic acid, and swelling or penetrating agents, e.g. urea, thiourea, formamide, acetamide, ethyl alcohol, acetone, dioxane, 2-butoxy-ethanol and other glycol monoalkyl ethers, may also be included in the composition.  The composition may be emulsified with, for example, glycol stearate, to form a cream. Specification 710,134 is referred to.
PURPOSE: A pharmaceutical composition is provided to prevent or treat diseases caused by angiogenesis using a compound having an activity of suppressing angiogenesis. CONSTITUTION: A pharmaceutical composition for preventing or treating diseases caused by angiogenesis contains a compound of chemical formula 1 as an active ingredient. The composition further contains a pharmaceutically acceptable carrier or excipient. In chemical formula 1, A is 'substituted or unsubstituted' phenyl, tolyl, naphthyl, anthryl, fluorenyl, pyridyl, pyrrole, quinoline, furan, thiophene, benzo thiophene or benzofuran. The substitution group is straight or branched alkyl group of C1-C20, alkoxy of C1-C20, cycloalkyl group of C5-c7, halogen group or acyl group. The diseases caused by angiogenesis include rheumatoid arthritis, degenerative arthritis, and septic arthritis.
Obesity in children remains a major public health problem, with the current prevalence in youth ages 2-19 years estimated to be 19.7%. Despite progress in identifying risk factors, current models do not accurately predict development of obesity in early childhood. There is also substantial individual variability in response to a given intervention that is not well understood. On April 29-30, 2021, the National Institutes of Health convened a virtual workshop on "Understanding Risk and Causal Mechanisms for Developing Obesity in Infants and Young Children." The workshop brought together scientists from diverse disciplines to discuss (1) what is known regarding epidemiology and underlying biological and behavioral mechanisms for rapid weight gain and development of obesity and (2) what new approaches can improve risk prediction and gain novel insights into causes of obesity in early life. Participants identified gaps and opportunities for future research to advance understanding of risk and underlying mechanisms for development of obesity in early life. It was emphasized that future studies will require multi-disciplinary efforts across basic, behavioral, and clinical sciences. An exposome framework is needed to elucidate how behavioral, biological, and environmental risk factors interact. Use of novel statistical methods may provide greater insights into causal mechanisms.
BACKGROUND: Sleep disorders (SD) are known to have a profound impact on human health and quality of life although their exact pathogenic mechanisms remain poorly understood.
METHODS: The study first accessed SD datasets from the GEO and identified DEGs. These DEGs were then subjected to gene set enrichment analysis. Several advanced techniques, including the RF, SVM-RFE, PPI networks, and LASSO methodologies, were utilized to identify hub genes closely associated with SD. Additionally, the ssGSEA approach was employed to analyze immune cell infiltration and functional gene set scores in SD. DEGs were also scrutinized in relation to miRNA, and the DGIdb database was used to explore potential pharmacological treatments for SD. Furthermore, in an SD murine model, the expression levels of these hub genes were confirmed through RT-qPCR and Western Blot analyses.
RESULTS: The findings of the study indicate that DEGs are significantly enriched in functions and pathways related to immune cell activity, stress response, and neural system regulation. The analysis of immunoinfiltration demonstrated a marked elevation in the levels of Activated CD4+ T cells and CD8+ T cells in the SD cohort, accompanied by a notable rise in Central memory CD4 T cells, Central memory CD8 T cells, and Natural killer T cells. Using machine learning algorithms, the study also identified hub genes closely associated with SD, including IPO9, RAP2A, DDX17, MBNL2, PIK3AP1, and ZNF385A. Based on these genes, an SD diagnostic model was constructed and its efficacy validated across multiple datasets. In the SD murine model, the mRNA and protein expressions of these 6 hub genes were found to be consistent with the results of the bioinformatics analysis.
CONCLUSION: In conclusion, this study identified 6 genes closely linked to SD, which may play pivotal roles in neural system development, the immune microenvironment, and inflammatory responses. Additionally, the key gene-based SD diagnostic model constructed in this study, validated on multiple datasets showed a high degree of reliability and accuracy, predicting its wide potential for clinical applications. However, limited by the range of data sources and sample size, this may affect the generalizability of the results.
Burnout appears to be highly prevalent among oncology nurses, which was a problem not only for the nurses themselves but for the patients for whom they provide care. And burnout-associated biomarkers remain controversial, and their potential roles in burnout are still unclear.

This study was a randomized controlled trial in which the independent variable was group psychological intervention, while the dependent variables were pre- and post-intervention scores on the Maslach burnout inventory and on the psychological capital scale, as well as values for various immunological indicators. In Stage 1 of the study, recruited subjects completed the psychological capital questionnaire and blood was sampled. In Stage 2, the research team administered a custom-designed psychological capital intervention (PCI) to part of the sample, while the other part received routine care . The PCI group received 1 h of counseling twice weekly for a total of 24 weeks in total. In Stage 3, the PCI and control groups completed the questionnaires again and provided blood samples.
Participants will receive up to 8 weeks of alectinib neoadjuvant treatment before undergoing surgical resection per standard of care. All participants that undergo surgical resection and whose tumors have pathological response or lack radiographic progression will be eligible for the Adjuvant Treatment Phase with alectinib. Adjuvant therapy will consist of 4 cycles of chemotherapy followed by up to 2 years of alectinib.
This is a single arm pilot study of 6-8 families to test the feasibility and acceptability of a modified version of the REACH-VA caregiver intervention in Vietnam. The REACH-VA caregiver intervention is an evidence-based intervention that has been shown to be effective in multicultural populations in the US. The model has been modified for use in Vietnam. This study will test the modified model in Vietnam. Participants in this study will be adult family caregivers of non-institutionalized persons with dementia who are living in Hanoi, Vietnam. They will receive 4-6 sessions delivered over the course of 2-3 months that will included the following components: 1) education about the nature of the disease, 2) risk assessment, 3) enhancing caregiver skills and problem-solving, and 4) caregiver stress reduction. The intervention will be delivered by a social worker or nurse using a Vietnamese language versions of the REACH-VA protocol and caregiver intervention notebook.