anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is an open-label (all patients and study personnel will know the identity of the administered study agents), multi-center, drug-drug interaction study. Approximately 18 patients may be enrolled in this study, and there will be one treatment group. All patients will receive a single subcutaneous (SC) dose of sirukumab. Cytochrome P450 (CYP) enzyme-specific study agents (5-probe cocktail) will consist of oral doses of midazolam, warfarin/vitamin K, omeprazole, and caffeine administered on 4 separate occasions throughout the study. A blood sample for CYP genetic analysis (genotyping) will be collected during screening from all prospective patients to determine eligibility for the study. Participation in CYP genotyping prescreening is mandatory for all patients. The CYP genotyping blood sample will not be used for any additional genetic research and will be destroyed after completion of this study. The total duration of study participation will be approximately 12 weeks for all patients included in the study, including a screening visit up to 4 weeks prior to first study agent administration. Patients will have five in-patient periods, four consisting of 3 days and 2 nights each and one consisting of 2 days and 1 night. Patients safety will be monitored throughout the study, and there will be approximately 7 weeks of safety follow-up after sirukumab administration.
PURPOSE: The authors hypothesize that optical coherence tomography angiography (OCTA)-visualized vascular morphology may be a predictor of choroidal neovascularization status in age-related macular degeneration (AMD). The authors thus evaluated the use of artificial intelligence (AI) to predict different stages of AMD disease based on OCTA en face 2D projections scans.
METHODS: Retrospective cross-sectional study based on collected 2D OCTA data from 310 high-resolution scans. Based on OCT B-scan fluid and clinical status, OCTA was classified as normal, dry AMD, wet AMD active, and wet AMD in remission with no signs of activity. Two human experts graded the same test set, and a consensus grading between two experts was used for the prediction of four categories.
RESULTS: The AI can achieve 80.36% accuracy on a four-category grading task with 2D OCTA projections. The sensitivity of prediction by AI was 0.7857 (active), 0.7142 (remission), 0.9286 (dry AMD), and 0.9286 (normal) and the specificity was 0.9524, 0.9524, 0.9286, and 0.9524, respectively. The sensitivity of prediction by human experts was 0.4286 active choroidal neovascularization, 0.2143 remission, 0.8571 dry AMD, and 0.8571 normal with specificity of 0.7619, 0.9286, 0.7857, and 0.9762, respectively. The overall AI classification prediction was significantly better than the human (odds ratio = 1.95, P = 0.0021).
CONCLUSION: These data show that choroidal neovascularization morphology can be used to predict disease activity by AI; longitudinal studies are needed to better understand the evolution of choroidal neovascularization and features that predict reactivation. Future studies will be able to evaluate the additional predicative value of OCTA on top of other imaging characteristics (i.e., fluid location on OCT B scans) to help predict response to treatment.
This study investigated the effects of a foot core intervention on the coordination of foot joints in recreational runners. This was a secondary analysis from a randomized controlled trial conducted with 87 recreational runners allocated to the control group (CG), which followed a placebo lower limb stretching protocol, or the intervention group (IG), which underwent an 8-week (3 times/week) foot core training. The participants ran on a force-instrumented treadmill at a self-selected speed (9.5-10.5 km/h) while the foot segment motion was captured. The vector coding technique was used to assess inter-joint coordination for four selected coupled segment and joint angles. The coordination patterns of the calcaneus and midfoot (CalMid) and midfoot and metatarsus (MidMet) joint pairs were affected. In the frontal plane, IG showed an in-phase with proximal dominancy coordination at heel strike, with a decrease in its frequency after the training (P=0.018), suggesting a longer foot supination. Additionally, IG showed an anti-phase with distal dominancy pattern at early stance compared to CG due to a smaller but earlier inversion of the CalMid-MidMet pair (P=0.020). The intervention also had an effect on the transverse plane of the CalMid-MidMet pair, with IG showing a significantly greater frequency of anti-phase coordination with proximal dominancy during propulsion than CG (P=0.013), probably due to a reduction in the CalMid abduction. Overall, the results suggested that the foot core intervention reduces the occurrence of running-related injuries by increasing the resistance to calcaneus pronation and building a more rigid and efficient lever during push-off.
Sham stimulation and medication. The pseudo-stimulation method was to flip the magnetic head at 90 degrees with the scalp, The stimulation parameters were 10Hz frequency and 120%MT intensity. 50 treatment sequences were given each time, with 60 stimulation times for each sequence, the sequence interval was 30 seconds, and a total of 3000 stimulation times for each treatment. The patients were treated once a day for 15 days. Medical treatment is selective serotonin reuptake inhibitors/serotonin-noradrenaline reuptake inhibitors (SSRIs/SNRIs).
Microsurgery is the gold standard for hard and soft tissue reconstruction in head and neck neoplasia and malformations. Fibular, iliac crest, and scapular free flaps are the main choices for reconstructive surgery of the jaws. Although widely described in the literature, no statistical comparison analysis of the donor site morbidity of these has been performed to our knowledge. Therefore, in this study, the medical records of patients who underwent microsurgical jaw reconstruction at the Maxillofacial Oncological Reconstructive Surgery Unit of Umberto I General Hospital in Rome between 2011 and 2021 were analysed retrospectively. Inclusion criteria were complete clinical and radiological records, microsurgical reconstruction harvesting one of the three flaps, and a minimum follow up of 12 months. Principal donor site complications were recorded and compared among the flaps. The data were analysed using IBM SPSS Statistics (28.0.1.1, IBM Corp). The study enrolled 220 patients: 103 with deep circumflex iliac artery (DCIA) flaps, 87 with fibular free flaps (FFF), and 30 with scapular bone flaps (SBF). The main DCIA donor site complications were dysaesthesia (13.6%), abdominal hernia (2.9%), dehiscence (1.9%), infection (1.9%), and anterior superior iliac spinal fracture (1.9%). Similarly, the main FFF complications were dehiscence (8%), skin graft necrosis (6.9%), infection (5.7%), and dysaesthesia (3.4%). Subcutaneous seroma occurred in 13.3% of SBF patients and dehiscence in 6.7%. Regional dysaesthesia occurred significantly (p < 0.05) more often in DCIA than FFF or SBF patients. Dehiscence was significantly (p < 0.05) more frequent in FFF than DCIA or SBF patients. All flaps were safe and associated with low donor site morbidity. The jaws should be reconstructed selecting the flap that best satisfies the reconstructive needs based on the patient's clinical features.
FIELD: medicine. SUBSTANCE: method involves applying antioxidant agents like sodium hypochlorite. The antioxidant is introduced into a peripheral vein by dripping. Sodium hypochlorite concentration in the solution is 30 mg/l to provide the dose of 1.5-1.8 ml/kg of patient body weight. The procedure is repeated 3-5 times with 1-2 days interval. EFFECT: improved patient life quality in diabetes mellitus cases. 2 cl
<P>PROBLEM TO BE SOLVED: To prevent retrieval precision from getting low caused by a dispersion of image quality in a clinical image, when registering the clinical images generated in different environments (different hospitals) in one case information database to be used for retrieval of similar cases.  <P>SOLUTION: This case registration system 2 is provided with a registration request receiving part 21, a case image generation part 22 and a registration part 25. The registration request receiving part (means) 21 receives a registration request including the clinical image from a diagnostic system in the hospital or the like. The case image generation part (means) 22 generates a case image of uniform image quality suitable for the retrieval, by processing the clinical image included in the registration request by an image processing means 23. The registration part (means) 25 registers the case information including the generated case image into the case information database.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Subjects in this group previously received three doses of 4CMenB and routine vaccine at 2, 4 and 6 months of age,respectively. They also received a booster (fourth) dose at 12 months of age concomitantly with one dose of MMRV vaccine.
Sympathetic stimulation is necessary in supporting circulatory function in congestive heart failure, and beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure. In patients who have congestive heart failure controlled by digitalis and/or diuretics, atenolol and chlorthalidone should be administered cautiously. Both digitalis and atenolol slow AV conduction.

IN PATIENTS WITHOUT A HISTORY OF CARDIAC FAILURE, continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. At the first sign or symptom of impending cardiac failure, patients should be treated appropriately according to currently recommended guidelines, and the response observed closely. If cardiac failure continues despite adequate treatment, atenolol and chlorthalidone should be withdrawn. (SeeDOSAGE AND ADMINISTRATION.)
A device and method against a respiratory virus. The device against a respiratory virus comprises an antiviral liquid and a nebulizer. The antiviral liquid contains hypochlorous acid. The nebulizer is provided with an accommodation space and an outlet. The accommodation space is in communication with the outlet, and is used for containing the antiviral liquid. The nebulizer is used for nebulizing the antiviral liquid to form aerosol particles, and the aerosol particles are discharged through the outlet.
Aim: The incidence of drug-induced sarcoidosis-like reactions (DISR) in patients treated with immune checkpoint inhibitors (ICIs) is rising. We determine the incidence and characteristics of DISR in a metastatic renal cell carcinoma (mRCC) population. Methods: We retrospectively reviewed clinico-radiological data of 83 mRCC patients treated at a single institution with immune-based combinations. Results: 15 patients received immune-doublet (ipilimumab-nivolumab), while 68 patients received other immune-based combinations. Two cases of DISR (2.4%) were evidenced, with enlargement of mediastinal lymph nodes that mimicked disease progression, thus requiring a biopsy which showed histological features of DISR. Conclusion: In our series of the incidence of DISR, radiological and clinical features, are in line with literature. DISR diagnosis is often only radiological, and its occurrence is possibly associated with a better outcome.
Disclosed are techniques for training a machine learning model. A training data set comprising a plurality of electrocardiogram (ECG) measurements and corresponding analyte measurements for each of the plurality of ECG measurements is provided. For each ECG measurement of the training data set, an estimated analyte level at a time of the ECG measurement is determined based on the corresponding set of analyte measurements. The estimated analyte level may be determined using statistical estimation techniques. If it is determined that the estimated analyte level at the time of the ECG measurement meets a certainty threshold, the ECG measurement is labeled based on the estimated analyte level at the time of the ECG measurement. A machine learning is trained to predict a level of an analyte based on ECG data, where the training is done using each of the plurality of ECG measurements that are labeled.
The present invention discloses a method for producing an antineoplastic medicament from silkworms, which belongs to the technical field of polypeptide medicament production by using genetic engineering in pharmaceutical engineering of a biological technology. Recombined viruses are obtained by recombining genes with human esoderma chalone through a bombyx mori baculovirus expression system, are submitted to China General Microbiological Culture Collection Center in ZhongGuan cun of Beijing to be preserved on July2th 2001, and have a preservation number of CGMCCNO. 0592. The recombined viruses are inoculated to the larvae and the pupae of bombyx mori to be expressed and processed through separation, purification and freeze drying to be prepared into an injection medicine and an oral medicine. Animal tests prove that the anticancer medicine has obvious function o inhibiting the tumor growth of a mouse, and the method becomes a new method for preparing an antineoplastic therapeutic medicine. Compared with the prior art, the method for producing an antineoplastic medicament from silkworms has the advantages of easy raw material obtainment, low production cost and good therapeutic effect.
BACKGROUND: Fatigue is a common complaint among older adults with hearing loss. The impact of addressing hearing loss on fatigue symptoms has not been studied in a randomized controlled trial. In a secondary analysis of the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study, we investigated the effect of hearing intervention versus health education control on 3-year change in fatigue in community-dwelling older adults with hearing loss.
METHODS: Participants aged 70-84 years old with untreated hearing loss recruited across 4 study sites in the United States (Forsyth County, North Carolina; Jackson, Mississippi; Minneapolis, Minnesota; Washington County, Maryland) were randomized (1:1) to hearing intervention or health education control and followed for 3 years. Three-year change in fatigue symptoms was measured by 2 instruments (RAND-36 and PROMIS). We estimated the intervention effect as the difference in the 3-year change in fatigue between intervention and control groups using a linear mixed-effects model under the intention-to-treat principle.
RESULTS: Participants (n = 977) had a mean age (SD) of 76.8 (4.0) years, were 53.5% female and 87.8% White. Over 3 years, a beneficial effect of the hearing intervention versus health education control on fatigue was observed using the RAND-fatigue score (β = -0.12 [95% CI: -0.22, -0.02]). Estimates also suggested beneficial effect of hearing intervention on fatigue when measured by the PROMIS-fatigue score (β = -0.32 [95% CI: -1.15, 0.51]).
CONCLUSIONS: Our findings suggest that hearing intervention may reduce fatigue over 3 years among older adults with hearing loss.
A composition having the capability of removing a risk factor during exercise, which can be applied to health foods and pharmaceuticals for preventing risks during exercise, such as a sudden death; a food for sports or a pharmaceutical composition for persons with a normal healthy body, such as professionals of sports, sport players or athletes, sport enthusiasts, persons who want to do sports, persons who aim to improve stamina; and a nutritious food for improving motor functions, which can enhance the aerobic capacity and is useful as auxiliary means for improving the athletic capability in long-distance running. The composition is characterized by containing an n-3 highly unsaturated fatty acid as the active ingredient and has the capability of removing a risk factor during exercise, particularly the capability of preventing  athletic anemia. The above n-3 highly unsaturated fatty acid refers to n-3 highly unsaturated fatty acids and/or derivatives thereof, preferably eicosapentanenoic acid and/or docosahexaenoic acid. It is most preferably in the form of a natural triglyceride, particularly a fish oil. The above composition may be used as a medicament or a food composition, particularly a food for sports. In the case of the medicament, the derivative is a pharmaceutically acceptable salt, ester, or amide. The above capability of removing a risk factor refers to the capabilities of improving the maximum oxygen intake and increasing the anaerobic threshold value by at least 3 %. In this case, the composition serves as a food for enhancing the motor function of persons with a normal healthy body.
To provide a medical information anonymizing system which anonymizes medical information by an anonymization method that is different for each piece of medical information, and an anonymization method setting device.SOLUTION: In the medical information anonymizing system, an inspection reservation system generates inspection reservation information when an inspection reservation by a medical image diagnosis device is accepted. The inspection reservation information includes a recipient of medical information and the purpose of use of medical information by the recipient. The medical image diagnosis device generates medical information of the subject based on the inspection reservation information. The anonymization method setting device selects anonymization reference information from anonymization list information in which the recipient of medical information, recipient information in which the purpose of use of medical information by the recipient is indicated, and anonymization reference information are associated. The anonymization method setting device adds the selected anonymization reference information to the medical information generated by the medical image diagnosis device. An anonymization device generates medical information, on the basis of the anonymization reference information added to the medical information, in which supplementary information and pixel data are anonymized.SELECTED DRAWING: Figure 1
<P>PROBLEM TO BE SOLVED: To obtain a moisture retention vegetable extract keeping the moisture retention effect over a long period, and obtain a moisture retention agent for external use, a cosmetic, a bathing agent and a detergent composition each containing the extract.  <P>SOLUTION: The moisture retention vegetable extract is composed of an extract of a mixture of Cinnamomum cassia, Poria cocos, Paeonia lactiflora, Gprunus persica, Paeonia suffruticosa and Coix lacryma-jobi Linne var. ma-yuen. The moisture retention agent for external use, the cosmetic, the bathing agent and the detergent composition contain the extract. A medicine obtained by decocting a mixture of the above herb drugs at specific ratios has the same composition as a Chinese medicine called as Keishi-Bukuryo-Ganryouka-Yokuinin believed to be effective for irregular menstruation, hysterics, acne, spot and chapped skin of hands and feet by internal use. The extract of the herb drug mixture contains a moisture retention vegetable component continuing the moisture retention effect for a long period and is effective for the prevention, amelioration or improvement of dry skin, roughened skin. chap, kibe, dandruff, itchiness and inflammatory diseases, and also for the treatment of dry hair, loose hair, split hair and cut hair and the application of luster to the hair by external use.  <P>COPYRIGHT: (C)2004,JPO
Participants will receive the following treatment combination: 4-Call Quitline Counseling, two weeks of Nicotine Patch, No SmokefreeTXT, and No Financial Incentives for Treatment Engagement. Each of the proactive counseling calls will last approximately 20 minutes. The Nicotine Patch treatment will consist of a two week supply of over-the-counter nicotine patches (21 mg for those who smoke 10 or more cigarettes per day (CPD); 14 mg for those who smoke fewer than 10 CPD). SmokefreeTXT text messaging in support of cessation will not be offered proactively. Financial Incentives for treatment engagement will not be offered.
The invention relates to an application of mycelia of Inonotus linteus by submerged culture and a composition thereof. First, a substrate is provided. Then, Inonotus linteus are inoculated into the substrate and submerged cultured for producing a submerged cultured substance. Finally, the submerged cultured substance is separated into solid part and liquid part, wherein the solid part includes the mycelia of Inonotus linteus. The mycelia of Phellinus linteus have the capability for preventing diabetic cataract. Therefore the mycelia of Inonotus linteus can be used to manufacture compositions for preventing diabetic cataract.
This study is a multi-center, prospective observational validation study. Patients aged 18 or above who are hospitalized at our hospital or who visited the outpatient clinic with arrhythmia symptoms (such as palpitation) after the clinical research approval will be enrolled. The normal sinus rhythm electrocardiogram (ECG) at the time of participation in the study is recorded and put into the artificial intelligence prediction algorithm. The result of risk stratification is blinded and will not be informed to both the research director and subjects. After applying wearable devices to the subject, the ECG recorded for the first week is analyzed to confirm the occurrence of paroxysmal atrial fibrillation (the gold standard for diagnosis of atrial fibrillation). When the wearable devices are removed, the 12 lead electrocardiogram will be taken again, and if it shows normal sinus rhythm electrocardiogram, then it will be put into the artificial intelligence prediction algorithm to calculate the result as well.
Nutritional intake during pregnancy can affect gestational length, fetal development, and impact postnatal growth and health in offspring. Perturbations in maternal nutrition with either an excess or deficiency in nutrients during pregnancy may have harmful effects on the offspring's development and increase the risk of developing chronic diseases later in life. In pregnancy, nutrients transfer from the mother to the fetus via the placenta. Essential fatty acids, linoleic acid (LA) and alpha linoleic acid (ALA), can only be obtained in the diet. In Western countries, the ratio of LA and ALA in the diet has increased dramatically in recent decades. Some animal and human studies have found a correlation between maternal intake of LA and birth weight; however, the association varies. In contrast, some human studies have demonstrated inconclusive findings regarding the correlation between cord blood levels of LA and birth outcomes. In addition, high dietary LA intake in animal studies in pregnancy increased the production of inflammatory markers such as prostaglandins, leukotrienes, cytokines, and tumour necrosis factor-alpha. This review aims to highlight the effect of high dietary LA intake during pregnancy on birth outcomes, obesity, maternal inflammatory markers, and the transfer of fatty acids across the placenta.