anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a Chinese herbal medicinal formula with effects of alopecia resistance and hair growth. The Chinese herbal medicinal formula comprises a first component which comprises 1800-2500g of Chinese angelica, 900-1500g of Syzygium aromaticum, 900-1500g of Panax ginseng, 2000-3000g of Zingiber officinale Roscoe, 1000-1500g of Zanthoxylum bungeanum, 500-800g of Ganoderma lucidum, 2000-3000g of licorice, 1000-1500g of Gastrodia elata Blume; and a second component which comprises 1800-2500g of Semen Sesami Nigrum, 800-1300g of Gleditasia sinesis Lam, 800-1300g of Carthamus tinctorius L., 1000-1500g of Semen Ginko, 2000-3000g of Fallopia multiflora (Thunb.) Harald, 1000-1500g of Rheum palmatum L., and 2000-3000g of Platycladus orientalis. The formula is prepared by technologiesof immersion of above raw materials with ethanol, distillation, filtration, blending and the like. A product with the formula of the invention has good effects of alopecia resistance and hair growth,can effectively break through problems of thickness and firmness of hair. Compared with products of a same kind in the market, the product of the invention has a lasting curative effect and is safe and nontoxic.
Model C consists of 4 weeks of monitoring with sleep diaries in Phase I. Phase II consists of CPAP for OSA.
PURPOSE: Provided is a composition containing polyphenol purified from green tea, ascorbic acid or its derivatives. The composition has anti-photoxic effect on the skin. Therefore, the composition is used for cosmetics, foods and pharmaceuticals for inhibition of ultraviolet injury. CONSTITUTION: The composition having anti-photoxic effect on the skin is characterized by containing 50-95 parts by weight of green tea polyphenols, and 5-50 parts by weight of ascorbic acid or its derivatives. The polyphenol is selected from epigallocatechin gallate, epicatechin gallate, and epigallocatechin. And ascorbic acid or its derivative is selected from ascorbic acid, ascorbyl palmitate, calcium ascorbate, magnesium ascorbate and zinc ascorbate.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, oncology, and can be used for chemoradiation therapy of low-located tumours of rectum and anal canal. For this purpose standard teleirradiation is performed. Additionally performed is conformal intraluminal brachytherapy of high power dose 5-10 Curie 4-6 irradiation sessions with reference dose 3.5 Gy at depth of 10 mm from irradiation source. In addition, on daily basis derivative of capecitabine fluoropyrimidines in amount 600 mg/m2 is introduced per os. ^ EFFECT: method allows to increase treatment efficiency, increase local response of tumour and reduce risk of metastases development due to exposing tumour to higher tumoricidal doses of irradiation and adding brachytherapy, intake of capecitabine enhancing local regress and reducing risk of tumour metastasis. ^ 3 ex
Colourless aqueous solutions of vitamin K activity are prepared by hydrolysing crude 2-methyl-1 : 4-dihydroxy naphthalene-diphosphoric acid-tetrachloride with water in the presence of a base, precipitating inorganic phosphates by the addition of a calcium compound and heating the solution.  If desired, the 2-methyl-1 : 4-dihydroxynaphthalene-diphosphoric acid calcium salt may be transformed into other salts which, if necessary, are purified by precipitation and re-dissolution in water.  In examples: (1) 2-Methyl - 1 : 4 - dihydroxynaphthalene is dissolved in pyridine and phosphorus oxychloride added and the diphosphoric acid-dichloride separated by extraction with benzene. The benzene solution is concentrated and hydrolysed with aqueous sodium hydroxide.  Calcium chloride is added, the solution is filtered and heated to boiling. (2) A suspension of 2 - methyl - 1 : 4 - dihydroxynaphthalene in toluene and dimethylaniline is added to phosphorus oxychloride in toluene.  The product is hydrolysed by the addition of water, neutralized and calcium chloride added.  The product is then boiled. (3) 2-Methyl-1 : 4-dihydroxynaphthalene is condensed as in example (2), and hydrolysed with water while adding calcium hydroxide.  The product is then boiled.  (4) 2-Methyl-1 : 4-dihydroxynaphthalene is condensed and the calcium salt formed as in examples (2) and (3). Oxalic acid and sodium hydroxide are added until a pH of 6-7 is reached.  The calcium oxalate is removed and the sodium salt thus obtained used directly or purified by the addition of alcohol until an oil just separates and allowing to crystallize.
The invention concerns an orally administered composition, i.e. a medically active agent for alleviation of uremic symptoms and a method for its preparation. The invention is based on the surprising observation that non-protein nitrogen compounds which accumulate in the body of uremic patients herein referred to as (NPN compounds: in the literature often designated as "uremia toxines") may be biodegraded and biosynthetized to harmless metabolites by utilizing selected non-pathogenic soil microorganisms, as a result of the action of these microorganisms in the intestine of the patient. In this way, at least part of the NPN compounds may be non-toxified, i.e., utilized by the organism. It is also observed that the NPN compounds, as such, do not represent any worthless "waste products" which necessarily have to be excreted. Instead only an excess of NPN not required and not utilized is excreted under normal circumstances. Further, the NPN:s do not constitute "end products" but are potentially valuable intermediates which allow a so called shuttle traffic in the internal metabolism, in other words: synthesis -><- degradation -><- resynthesis. In order to prevent an excess enrichment of unwanted NPN compounds in the body of patients suffering from irreversible progressive renal failure, the processes responsible for the internal metabolism must be "cycled backwards".
In BoNT-A treatment group patients received 200 units BoNT-A injection in the triceps surae (150iu) and tibial muscle posterior (50iu). Both groups received comprehensive rehabilitation for 8 weeks.
OBJECTIVE: To identify the risk factors of cervical high-grade squamous intraepithelial lesion(HSIL) complicated with occult cervical cancer and standardize the management of initial treatment for HSIL.
METHOD: The clinical data of patients who underwent total hysterectomy directly due to HSIL in the obstetrics and gynecology department of two tertiary hospitals and three secondary hospitals from 2018 to 2023 were collected. Their general characteristics, pathological parameters and survival status were analyzed. Logistic regression model was used to analyze the correlation between clinical parameters and postoperative pathological upgrading.
RESULT: 1. Among the 314 patients with HSIL who underwent total hysterectomy directly, 73.2% were from primary hospitals. 2. 25 patients (7.9%) were pathologically upgraded to cervical cancer, all of which were early invasive cancer. 3. Up to now, there was no recurrence or death in the 25 patients with early-stage invasive cancer, and the median follow-up period was 21 months(range 2-59 months). 4. Glandular involvement(OR 3.968; 95%CI 1.244-12.662) and lesion range ≥ 3 quadrants (OR 6.527; 95% CI 1.78-23.931), HPV 16/18 infection (OR 5.382; 95%CI 1.947-14.872), TCT ≥ ASC-H (OR 4.719; 95%CI 1.892-11.766) were independent risk factors that affected the upgrading of postoperative pathology. 5. The area under the curve (AUC) calculated by the Logistic regression model was 0.840, indicating that the predictive value was good.
CONCLUSION: There is a risk of occult cervical cancer in patients with HSIL. Glandular involvement, Lesion range ≥ 3 quadrants, HPV 16/18 infection and TCT ≥ ASC-H are independent risk factors for HSIL combined with occult cervical cancer. The prognosis of biopsy-proved HSIL patients who underwent extrafascial hysterectomy and unexpected early invasive cancer was later identified on specimen may be good.
A 10-minute lecture will be delivered before the start of the study. It will explain how to use the studied devices. Following the lecture all participants will be able to familiarise themselves with the equipment and practice for 30 minutes. A skill station will be set up containing an intubation manikin AT Kelly Torso (Laerdal Medical AS, Stavanger, Norway). A reduced movement of the cervical spine will be achieved by application of a Patriot® cervical collar (Össur hf., Reykjavik, Iceland). After completion of the initial practice the intubation manikin with the cervical collar on will be placed on and secured to the driver's seat of a medium-sized passenger car (FIAT S.p.A., Turin, Italy). The car will then be positioned on its left side and secured in place by firemen from a local fire brigade. The access to the manikin will only be allowed from the front i.e. through the opening created after removal of the windscreen. A single digit number will be allocated to each of the four studied devices i.e. 1 for the SLIPA device, 2 for the I-gel, 3 for the LMA Supreme and 4 for the LTS. Each study participant will be asked to randomly give a number (either 1, 2, 3 or 4) and will then be given the corresponding airway device to use. The maximum number of insertion attempts will be limited to three per device. The time required to insert the device and achieve a successful ventilation (Tiv) will be recorded. It will be measured using a stopwatch of a mobile phone (Apple Inc., Cupertino, California, USA). Efficacy of insertion/ventilation and the ease of use by the operator will also be assessed. The latter will be measured using an 11-point numerical rating scale (NRS) where 0 corresponds to a very difficult to use device and 10 indicates an easy to use and user-friendly device. A manual resuscitator (Ambu A/S, Ballerup, Denmark) will be used for ventilation and will be readily available to the paramedics. The study participants will perform all insertions with each of the four supraglottic airway devices. A failed insertion and ventilation is defined as an attempt during which the manikin cannot be ventilated or an attempt that lasted longer than 120 seconds. Only those who failed to ventilate will be allowed another attempt. All the obtained data will be analysed using Microsoft Office Excel 2021 spreadsheet (Microsoft Corporation, Redmond, WA, USA). The Kolmogorov-Smirnov test is utilised to determine whether the analysed variables matched the characteristics of a normal distribution. A paired Student t-test and the Wilcoxon signed-rank test will be used for data analysis. Based on our previous unpublished pilot study and assuming that the overall success rate of intubation in patients with a difficult airway would be 90% (α =0.05, 2-sided, β =0.1), 46 participants will be required. The final adjusted sample size, allowing a drop-out rate of about 10%, is 50 and this is the final number of participants enrolled into the study. A p-value of less than 0.05 (p\<0.05) is considered statistically significant.
Repair with suture anchors: The insertion points for the three suture anchors will be marked with electrocautery. The anchors will be placed approximately 2 mm from the articulate surface; placing them too superficially may increased the joint reactive force and lead to abnormal patella femora joint mechanics. Pilot holes will be drilled with a 3.2-mm drill bit parallel to the patella, avoiding penetration of the articular surface. Three Suture anchors (Arthrex, Naples FL) will be threaded with two No. 5 Fiberwire (Arthrex, Naples FL) sutures and will be inserted and deployed in the pilot holes in the usual manner.
Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that causes significant late morbidity and mortality following allogeneic hematopoietic cell transplantation. The "Close Assessment and Testing for Chronic GVHD (CATCH)" study is a multi-center Chronic GVHD Consortium prospective, longitudinal cohort study designed to enroll patients before hematopoietic cell transplantation and follow them closely to capture the development of chronic GVHD and to identify clinical and biologic biomarkers of chronic GVHD onset. Data are collected pre-transplant and every two months through one-year post-transplant with chart review thereafter. Evaluations include clinician assessment of chronic GVHD and its manifestations, patient-reported outcomes, multiple biospecimens (blood, saliva, tears, buccal mucosa and fecal samples, biopsies of skin and mouth), laboratory testing, and medical record abstraction. This report describes the rationale, design, and methods of the CATCH study, and invites collaboration with other investigators to leverage this resource. trial registration: This study is registered at www.clinicaltrials.gov as NCT04188912.
The invention belongs to the field of traditional Chinese medicine, and discloses a formula and a preparation method of an alopecia treating traditional Chinese medicine. The alopecia treating traditional Chinese medicine comprises the following Chinese herbs by weight: 11-27 parts of fallopia multiflora (thunb.) harald, 5-17 parts of black sesame, 4-18 parts of dodder, 6-15 parts of cnidium monnieri(l.)cuss, 7-14 parts of seasoned orange peel, 5-14 parts of curcumn aromatica, 6-12 parts of flemingia philippinensis merr. et rolfe, and 4-9 parts of camellia. The preparation method comprises drying, mixing and the like. The prepared alopecia treating traditional Chinese medicine has good effects of alopecia preventing and hair growing.
Clinical studies of NORPRAMIN did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Lower doses are recommended for elderly patients (see DOSAGE AND ADMINISTRATION).

The ratio of 2-hydroxydesipramine to desipramine may be increased in the elderly, most likely due to decreased renal elimination with aging.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

NORPRAMIN use in the elderly has been associated with a proneness to falling as well as confusional states (see ADVERSE REACTIONS).
Participants will first receive Lu AG13909 intravenously (IV) per predefined dosing schedule. Participants will then receive Lu AG13909 subcutaneously (SC) per predefined dosing schedule.
Sterile dry therapeutic and like preparations containing a very small proportion of a highly active substance are prepared by mixing in one or more steps a solution of the active substance with a solution of a diluent, concentrating the mixed solution to dryness and then admixing with the dry product more of the diluent, also in dry form, the operations being conducted under aseptic conditions.  The preparations may be formed into tablets using a vehicle such as 90 per cent alcohol and a little preservative such as tricresol. According to an example a highly purified tuberculin protein dissolved in very dilute aqueous caustic soda is mixed with an aqueous solution of milk sugar, and the combined solution filtered, tested for sterility, and evaporated to dryness at low temperature under vacuum.  The residue is ground in a ball mill and then further ground after addition of dry milk sugar.  The tuberculin protein employed is obtained from the filtrate of a culture of bacterium tuberculosis (human type) on a synthetic medium, by ultradialysis followed by precipitation of the protein by trichloracetic acid. Other active materials referred to are protein extracts, pollen extracts, bacterial proteins, alkaloids, gland extracts, and hormones such as the anterior pituitary hormone; other diluents specified are boric acid and cane sugar.
Individuals with early stage dementia who attended a Adult Day Care Program at least twice a week. Participants engaged in a strengthening exercise program three to five times per week for 10 weeks.
This study addressed the critical gap in research on the academic English vocabulary knowledge of deaf and hard-of-hearing (DHH) students at the college level, with a specific focus on academic English verbs. An English vocabulary test was developed to assess knowledge of academic verbs at three distinct corpus-defined lexical frequency ranges. The test was administered to the DHH students along with two comparison groups of college peers-students of English as an Additional Language (EAL)1 and hearing native-English-speaking students. Results revealed near-ceiling performance by hearing native speakers but significant vocabulary challenges in the DHH and EAL learner groups, who exhibited parallel lexical knowledge. Learner group performance increased as verb frequency range increased and as overall English proficiency level increased. The findings demonstrate that lexical frequency effects guide English verb acquisition in the targeted populations.2.
INTRODUCTION: Many studies have demonstrated significant antibiotic resistance by commonly isolated organisms. This is an eye-opener for the clinicians, who prescribe antibiotics day in and out. This situation shifts our attention towards the usage of antiseptic measures, which can at times play an important role in preventing and treating various infections.
METHOD: This is a double-blinded randomized controlled study that compares the bundle approach to the conventional approach for the prevention of surgical site infections in patients of peritonitis undergoing midline laparotomy in emergency. The bundle approach includes three measures, namely, painting of surgical site with chlorhexidine, dabbing the wound with povidone-iodine after the closure of the rectus sheath, and application of chlorhexidine-impregnated gauze piece over the skin wound.
RESULTS: The total sample size was 64 (32 in each arm). The rate of surgical site infection was significantly lower in the test arm (21.8%) as compared to the conventional arm (46.8%). The mean length of hospital stay was shorter by one day in the test arm, although, not significant. The isolates from the peritoneal fluid culture and wound culture were mostly gram-negative organisms. Most of the organisms exhibited resistance toward third generation cephalosporins, fluoroquinolones, and aminoglycosides.
CONCLUSION: Antibiotic resistance is a burning concern in today's world. Alternative methods of preventing infection in the form of using antiseptics should be sought. Although our study was limited to emergency cases, this bundle approach can be implemented in elective cases as well.
We propose a rigorous randomized trial to evaluate an innovative stepped care for suicide prevention intervention for adolescents and young adults, compared to a zero suicide program initiated by a health system. An effective zero suicide strategy for this age group is critically needed because this is a developmental period when: 1) suicide is the second leading cause of death, accounting for more deaths than any medical illness; 2) suicidal tendencies and behaviors often first occur in this age span; 3) rates of suicide and suicide attempts increase dramatically; and 4) effective intervention can reduce risk, suffering, and costs over lifetimes.

The project combines a partnership with a health system that has strong infrastructure and commitment to quality improvement for zero suicide with a research team that has successfully implemented collaborative stepped care interventions in health systems and has expertise in clinical, health services, economics, and policy research and dissemination. We will identify and enroll 300 youths ages 12-24 with elevated suicide and suicide attempt risk using a multi-stage screening process. Eligible youths will be randomized to: 1) zero suicide best practices, which emphasizes health system quality improvement (ZSQI); or 2) ZSQI plus stepped care for suicide prevention, which integrates evidence-based suicide prevention with primary care and emergency services. Prior research demonstrates the value of similar integrated medical-behavioral health interventions for improving patient outcomes, rates of care, and continuity of care- a critical issue for zero suicide efforts, as many youths discontinue care prematurely despite continuing risk. The ZSQI plus stepped care for suicide prevention approach uses: 1) risk assessments to triage youths to appropriate care levels; 2) care managers to deliver cognitive behavior therapy and dialectical behavior therapy skills training and support primary care and emergency clinicians with patient evaluation and treatment; 3) internet-delivered cognitive-behavior therapy and dialectical behavior therapy treatment components plus access to coaching support for lower risk youths, with stepped up in-person group and/or individual treatment added for higher risk youths; and 4) regular monitoring of patient outcomes, with feedback to clinicians to facilitate decision-making and use of the stepped care algorithms. The intervention period is 12 months: 6 months of acute treatment; and 6 months of continuation treatment. Results will provide critical information for health systems and science regarding the potential to achieve zero suicide goals by integrating state of the art science with practice quality improvement.
Liver transplantation remains the only definitive treatment for end-stage liver diseases. However, the increasing prevalence of fatty liver disease among potential donors exacerbates the shortage of suitable organs. This study evaluates the efficacy of the preservation solution Institut Georges Lopez-2 (IGL-2) compared to Histidine-Tryptophan-Ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions in mitigating ischemia-reperfusion injury (IRI) in steatotic livers. Using Zucker Obese rat livers, we assessed the impact of 24-h static cold storage (SCS) with each solution on transaminase release, glutathione redox balance, antioxidant enzyme activity, lipoperoxidation, and inflammation markers. IGL-2 and UW solutions demonstrated reduced transaminase and lactate levels compared to HTK, indicating better preservation of liver integrity. IGL-2 maintained a higher reduced glutathione/oxidized glutathione (GSH/GSSG) ratio, suggesting more effective management of oxidative stress. Antioxidant enzyme activities catalase, superoxide dismutase, and glutathione peroxidase (CAT, SOD, GPX) were higher in IGL-2 preserved livers, contributing to decreased oxidative damage. Lipid peroxidation markers and inflammatory markers were lower in IGL-2 than in HTK, indicating reduced oxidative stress and inflammation. Additionally, improved mitochondrial function was observed in the IGL-2 group, correlating with reduced reactive oxygen species (ROS) production and lipid peroxidation. These findings suggest that IGL-2 offers superior preservation of liver viability, reduces oxidative stress, and minimizes inflammation compared to HTK and UW solutions. By maintaining a higher ratio of reduced glutathione and antioxidant enzyme activity, IGL-2 effectively mitigates the harmful effects of ischemia-reperfusion injury. The reduced lipid peroxidation and inflammation in the IGL-2 group further underscore its potential in improving liver transplant outcomes. These results highlight the importance of optimizing preservation solutions to enhance the viability and functionality of donor organs, potentially expanding the donor pool and improving the success rates of liver transplantation. Future research should focus on refining preservation techniques and exploring additional protective agents to further improve organ preservation and transplant outcomes.