anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention belongs to the technical field of medicinal preparations, particularly to an osmotic pump release-control preparation containing ligustrazine and a preparing method thereof. The present invention is composed of a solid medicine, osmotically active substances, a tablet core made of an excipient, and a release-control coating which is outside wrapped by a non-soluble thin film with water permeability and no medical permeability, wherein the film of the coating is provided with small holes, and a protective film coating is wrapped. The present invention is characterized in that the solid medicine is ligustrazine. The velocity of the medical constant-speed release can be conveniently and effectively adjusted by adjusting the prescription of the tablet core. The present invention can stabilize the blood medical level, increase the medical safety and reduce administration times so as to reduce the side effect of the common preparation and increase the patient's compliance. Convenient use is provided for the patient.
FIELD: processing industry.SUBSTANCE: invention relates to the processing industry, in partiular to a method for producing collagen. Disclosed is a method for producing high-molecular collagen, wherein freshwater fish skins are additionally cut and sorted by the thickness of the skin prior to the primary washing. The primary washing is carried out with a solution with a fatty solvent based on a fruit acid. Hydrogen peroxide with a mass concentration of 4.0÷10.0% is used for the peroxide-alkaline treatment of rinsed skins and organic acid is used to achieve the pH of the solution of 1.0÷3.0. During the holding the ultrasonic action is carried out, after holding the skins in the solution of organic acids, they are ground to particles with a size of 2.0÷5.0 mm, neutralized with an alkaline solution to a pH of 4.5÷7.0, and after homogenization, the mixture is filtered from the residues of the fibrous skin. Distilled water is added to the filtrate in a ratio of 1:5÷1:10 and is exposed to cold sterilization and additional ultrafiltration for removing chemical impurities and concentration. It is then re-sterilized with ultraviolet.EFFECT: technical result consists in an increase in the yield of a high-quality collagen molecule in a hydrated form.12 cl, 2 ex
The invention discloses one and treat neurasthenic medicinal herb tea, this medicinal herb tea medicinal material component and quality proportioning thereof are as follows: rhizoma Gastrodiae 50～60, the fruit of Chinese wolfberry 80～100, wild lotus 100～120, gynostemma pentaphylla 80～100, rose 80～100. Method for making is that above-mentioned 5 kinds of medicinal materials are passed through to selected, dry, pulverizing, mixes afterwards according to prescription quality ratio, and the mixed powder obtaining adopts conventional production process of bagged tea, the bagged medicine tea that pack is made, and every packaging has dry mixing medicinal herb tea powder 10g. Instructions of taking is that boiling water brews as tea and drinks. Nearly 2 years of the clinical use of this medicinal herb tea, suffer from nervous breakdown patient take after this medicinal herb tea through 17,10 effects are remarkable, and 4 effectively, and 3 patients are without positive effect; Medicinal herb tea of the present invention, makes with crude drug, is a kind of safe health herb tea. It has advantages of taking convenience, micro-sweet, the successful of mouthfeel. Be applicable to suffer from the crowd of nervous breakdown.
BACKGROUND: Postoperative atrial fibrillation (POAF) is the most common arrhythmic complication following cardiac surgery. Current guidelines suggest beta-blockers for the prevention of POAF. In comparing metoprolol succinate with carvedilol, the later has sparked interest in its usage as an important medication for POAF prevention.
METHODS: We considered randomized controlled studies (RCTs) and retrospective studies that evaluated the efficacy of carvedilol versus metoprolol for the prevention of POAF. After literature search, data extraction, and quality evaluation, pooled data were analyzed using either the fixed-effect or random-effect model using Review Manager 5.3. The Cochrane risk of bias tool was used to assess the bias of included studies. The incidence of POAF was the primary endpoint, while mortality rate and bradycardia were secondary outcomes.
RESULTS: In meta-analysis 5 RCTs and 2 retrospective studies with a total of 1000 patients were included. The overall effect did not favor the carvedilol over metoprolol groups in terms of mortality rate [risk ratio 0.45, 95 % CI (0.1-1.97), P=0.29] or incidence of bradycardia [risk ratio 0.63, 95 % CI (0.32-1.23), P=0.17]. However, the incidence of POAF was lower in patients who received carvedilol compared to metoprolol [risk ratio 0.54, 95 % CI (0.42-0.71), P < 0.00001].
CONCLUSION: In patients undergoing cardiac surgery, carvedilol may minimize the occurrence of POAF more effectively than metoprolol. To definitively establish the efficacy of carvedilol compared to metoprolol and other beta-blockers in the prevention of POAF, a large-scale, well-designed randomized controlled trials are required.
Interested patients who provisionally meet inclusion/exclusion criteria will attend NHNN for a screening visit to check study eligibility and to have any questions relating to study participation answered. Each patient will undertake two assessment visits at approximately four weeks apart. Study participants will withhold carbonic anhydrase inhibitor medications for 72 hours prior to assessment visits as is standard for McManis testing and restart their routine treatment immediately after each visit. Participants will be admitted as an NHNN day case. Following baseline assessments a localised attack of weakness will be induced by isometric exercise of the abductor digit minimi (ADM) in the hand as per McManis protocol below. Participants will be randomly assigned to either bumetanide or placebo for the first visit. Identical appearing capsules will be prepared to blind both researcher and participant to treatment allocation. The assigned treatment will be taken by mouth at the onset of a focal attack defined as 40% decrement in ADM CMAP amplitude compared to the maximum CMAP amplitude recorded during or after the exercise. During the admission each patient will be monitored according to the research protocol. At the end of the assessment protocol the participant will be discharged home. The duration of each admission will be approximately 6 hours The second assessment will follow an identical protocol to the first, but with the other treatment administered.
The invention discloses a nanoemulsion transdermal spray for treating dysmenorrheal and a preparation method thereof. The grain size of the nanoemulsion is 1-100nm and the nanoemulsion comprises the following components by weight percent: 30-45% of surfactant, 0.1-3% of cosurfactant, 1-3% of olibanum oil, 1-3% of angelica oil, 1-3% of rhizoma cyperi oil, 1-3% of folium artemisiae argyi oil, 0.5-2% of azone and 40-55% of deionized water. The nanoemulsion transdermal spray rapidly acts for relieving paint and has durable action, has various functions of stimulating and regulating menstruation, activating blood and warming uterus, warming channel and expelling cold, promoting the circulation of qi and relieving swelling, improving microcirculation and the like, and is not toxic and harmful to a human body. The product nanoemulsion transdermal spray disclosed by the invention is applied to abdomen skin and the abdomen skin is massaged until the product is absorbed. The nanoemulsion transdermal spray has fragrant smell and no pollution to clothes, thereby greatly improving compliance of the use of the medicament by patients. The nanoemulsion transdermal spray is simple in preparation method and low in production cost, is applicable to mass production, and has wide market prospect in the medicine field.
Patients received 1 capsule of Saccharomyces boulardii 250 ug BID plus dietary advice for 15 days. Dietary advice consisted of a low fermentation diet which was delivered as a written list of food and beverages that patients should avoid adapted to local habits and an oral explanation by a health professional.
ETHNOPHARMACOLOGICAL RELEVANCE: The Banxia-Houpu decoction (BHD), a renowned prescription documented in the Chinese medical book "The Synopsis of the Golden Chamber," has been proven to effectively mitigate inflammation within the central nervous system. Previous studies have demonstrated the efficacy of BHD in ameliorating symptoms in patients with obstructive sleep apnea (OSA). Nevertheless, the precise mechanisms and comprehensive effects of BHD on central system injury in OSA models have not been fully investigated.
AIM OF THE STUDY: To investigate whether BHD could inhibit neuroinflammation to decrease iron-induced neurotoxic injury in CIH mice.
MATERIALS AND METHODS: C57BL/6N mice were divided into the Con, CIH, and BHD groups. Mice were exposed to CIH (21%-5% FiO2, 3 min/cycle, 8 h/d), and BHD was administered by gavage (3.51, 7.01, and 14.02 g/kg). The polarization of microglia, inflammatory factors, hepcidin, and brain iron levels were determined.
RESULTS: The administration of BHD at a dosage of 7.01 g/kg demonstrated a significant reduction in neurobehavioral abnormalities, neuronal damage, and degeneration caused by CIH. BHD exhibited the ability to inhibit the transition of microglial polarization from M2 to M1 by upregulating CD163 expression and downregulating iNOS levels. Furthermore, BHD decreased pro-inflammatory factor levels and increased anti-inflammatory factor levels. Additionally, BHD was found to decrease hepcidin expression in astrocytes through the TLR4/MyD88/NF-κB signaling pathway. BHD reduced the total and neuronal iron levels by elevating FPN1 and reducing TfR1 levels. BHD exhibited positive effects on synapse and synaptic spine abnormalities, as well as an increase in the Bcl-2/Bax ratio, thereby mitigating neuronal damage induced by CIH.
CONCLUSIONS: Based on these findings, BHD holds potential as a therapeutic intervention for neural damage injuries, which offers a theoretical foundation for the treatment of patients with OSA in clinical.
The invention provides application of combined utilization of benzathine benzylpenicillin and kanamycin monosulfate in preparing medicine for livestock. By weight, 2.5-160 parts of benzathine benzylpenicillin and 1.25-80 parts of kanamycin monosulfate are combined. The invention further provides a medicine composition for livestock and a preparation method and application thereof. The medicine composition is prepared from, by weight, 2.5-160 parts of benzathine benzylpenicillin and 1.25-80 parts of kanamycin monosulfate. According to the medicine composition, the benzathine benzylpenicillin and the kanamycin monosulfate are combined to achieve the synergistic effect, and the unforeseeable technical effect is obtained. The medicine composition has the significant effect on treating diarrhea and respiratory tract infection of livestock and poultry, the death rate of newborn livestock and poultry can be greatly lowered, and a new medicine choice is provided for veterinarians clinically.
Cardiac magnetic resonance (CMR) has gained increasing clinical application in cardiopulmonary diseases. Due to its 3-dimensional nature, CMR is considered the gold-standard for quantifying left and right ventricular systolic function and size. Additionally, its high tissue contrast allows for a detailed characterization of myocardial tissue. Specifically, the use of techniques such as late gadolinium enhancement can be used to detect the presence of tiny amounts of myocardial scar. Other techniques have been shown to correlate strongly with myocardial iron content. Just as importantly, CMR perfusion imaging can accurately quantify myocardial blood flow and can provide tremendous insight into the function of the microcirculation. CMR's high spatial and temporal resolution, its 3-dimensional approach, its ability to characterize the tissue, and its ability to evaluate the micro- and macro-circulation make it a comprehensive technique for the evaluation of heart disease. Recently, one CMR study has already shown the presence of cardiac microvascular disease in a subset of adult sickle cell disease (SCD) patients in the absence of infarcted myocardium, myocardial iron overload, or coronary artery disease, increasing the evidence for the contribution of left heart disease to pulmonary hypertension (PH) development in these patients; unfortunately, strong conclusions could not be made because the study was underpowered. Thus, this proposal will leverage the advantages offered by CMR to better characterize and detect the PH and cardiopulmonary subphenotypes in the SCD patient population.
The safety and effectiveness of rosuvastatin as an adjunct to diet to reduce LDL-C have been established in pediatric patients 8 years of age and older with HeFH. Use of rosuvastatin for this indication is based on one 12-week controlled trial with a 40-week open-label extension period in 176 pediatric patients 10 years of age and older with HeFH and one 2-year open-label, uncontrolled trial in 175 pediatric patients 8 years of age and older with HeFH [see Clinical Studies (14)] . In the 1-year trial with a 12-week controlled phase, there was no detectable effect of rosuvastatin on growth, weight, BMI (body mass index), or sexual maturation in patients aged 10 to 17 years. 

The safety and effectiveness of rosuvastatin as an adjunct to other LDL-C-lowering therapies to reduce LDL-C have been established pediatric patients 7 years of age and older with HoFH. Use of rosuvastatin for this indication is based on a randomized, placebo-controlled, cross-over study in 14 pediatric patients 7 years of age and older with HoFH [see Clinical Studies (14)].

The safety and effectiveness of rosuvastatin have not been established in pediatric patients younger than 8 years of age with HeFH, younger than 7 years of age with HoFH, or in pediatric patients with other types of hyperlipidemia (other than HeFH or HoFH).
PURPOSE OF REVIEW: To analyze the evolving epidemiologic trends in thyroid disease, focusing on risk factors, underlying drivers of these changes, and their implications on clinical practice and research priorities.
RECENT FINDINGS: Thyroid disease remains one of the most prevalent groups of disorders globally, and the shift in its frequency and distribution is multifactorial. The prevalence of hypothyroidism increases with age, although normal thyrotropin ranges appear to be age-dependent, raising concern for potentially inappropriate levothyroxine use. Hyperthyroidism and Graves' disease continue to be predominant in reproductive-age women but exhibit a milder phenotype at diagnosis. Thyroid nodules are increasingly found in asymptomatic patients, likely from more widespread use of neck and chest imaging. Thyroid cancer incidence has risen exponentially over the years, mostly driven by overdiagnosis of low-risk tumors; however, a small rise in incidence of higher risk tumors has been noted. Obesity appears to be a risk factor for thyroid cancer occurrence and more aggressive forms of the disease.
SUMMARY: Understanding epidemiologic trends in thyroid disease is crucial for guiding clinical practice and research efforts, aiming to optimize patient outcomes while preventing unnecessary and potentially harmful interventions.
Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder characterized by pulmonary vascular remodeling (PVR), primarily due to the excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). This study aimed to investigate the role and molecular mechanism of SOX9 in hypoxic PH in rats. The findings revealed that SOX9 was upregulated in the pulmonary arteries and PASMCs of hypoxia-exposed rats. SOX9 knockdown inhibited hypoxia-induced proliferation and migration of PASMCs, reduced PVR, and subsequently alleviated hypoxia-induced PH in rats, suggesting that SOX9 plays a critical role in PH. Further investigation demonstrated that SOX9 interacted with DPP4, preventing its ubiquitin degradation in hypoxia-exposed PASMCs. DPP4 knockdown inhibited hypoxia-induced PASMC proliferation and migration, and administration of the DPP4 inhibitor sitagliptin (5 mg/kg) significantly reduced PVR and alleviated hypoxia-induced PH in rats, indicating that SOX9 contributes to PH by stabilizing DPP4. The results also showed that hypoxia induced YAP1 expression and dephosphorylation, leading to YAP1 nuclear localization. YAP1 knockdown promoted the degradation of HIF-1α in hypoxia-exposed PASMCs and inhibited hypoxia-induced proliferation and migration of PASMCs. Additionally, HIF-1α, as a transcription factor, promoted SOX9 expression by binding to the SOX9 promoter in hypoxia-exposed PASMCs. In conclusion, hypoxia promotes the proliferation and migration of PASMCs through the regulation of the YAP1/HIF-1α/SOX9/DPP4 signaling pathway, leading to PH in rats. These findings suggest that SOX9 may serve as a potential prognostic marker and therapeutic target for PH.
### CYP 3A4 Inhibitors (e.g. Macrolide Antibiotics and Protease Inhibitors)

See CONTRAINDICATIONS and WARNINGS. 

Ergotamine tartrate and caffeine tablets should not be administered with other vasoconstrictors. Use with sympathomimetics (pressor agents) may cause extreme elevation of blood pressure. The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of ergotamine tartrate and caffeine tablets by blocking the vasodilating property of epinephrine. Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.

The blood levels of ergotamine-containing drugs are reported to be elevated by the concomitant administration of macrolide antibiotics and vasospastic reactions have been reported with therapeutic doses of the ergotamine-containing drugs when coadministered with these antibiotics.
The invention provides a health care life nourishing tea with functions of promoting blood circulation, stimulating meridians and nourishing spleen and stomach. The tea comprises Anhua black tea, dodder, Achyranthes, radix astragali, yam, poria with hostwood, dipsacus and honey. The ingredients are proportionally combined according to the principle of 'tea absorbing medicine momentum, medicine lending tea force'. It not only possesses the original pure fragrance and deliciousness of tea leaves, but also augments the life nourishing function of tea. The transformation of inherent substances in the tea and the interaction of metabolism products of microorganisms in the tea form the physical foundation of the special health care function of Anhua black tea. Drinking the tea can have the effects of promoting blood circulation, stimulating meridians, nourishing spleen and stomach, nourishing the liver and kidney, strengthening the sinew and bones, replenishing the vital essence and improving eyesight, promoting diuresis for stranguria, benefiting the lung and enriching the saliva, arresting seminal emission and calming the mind and easing the spirits.
Each 100 μl actuation contains 2.5 mg delta-9-tetrahydrocannabinol (THC) and 2.5 mg cannabidiol (CBD). The maximum permitted dose was 48 actuations in any 24 hour period (120 mg THC/120 mg CBD).
Nonsurgical treatment involving the injection of 1.5 ml of 50% ethanol (1 ml of 99.5% ethanol diluted in 1ml of 2% xylocaine) into the upper palate. 0.5 ml of the solution will be implemented in three different regions of the submucosal layer of the soft palate, one median and two paramedians.
FIELD: medicine, pharmacy. SUBSTANCE: invention proposes agent that is a spirituous extract of medicinal plants. Also, invention proposes method of preparing this agent involving triple extraction with 40% ethyl alcohol. Agent shows the expressed pharmacotherapeutic effect. EFFECT: broadened spectrum of biological activity, enhanced pharmacological activity. 2 cl, 1 tbl, 3 ex
A diagnostic care coordination system assists a caregiver with treating a patient. The system comprises a diagnostic engine and a care engine. The diagnostic engine is configured to generate a working diagnosis of the patient. The diagnostic engine includes a static diagnosing web containing a plurality of information nodes and a dynamic diagnosing analyzer for presenting to a user a plurality of information requests. The dynamic diagnosing analyzer navigates a user through the plurality of information nodes of the static diagnosing web based upon received responses to said plurality of information requests. Based upon a route through the static diagnosing web as taken by the dynamic diagnosing analyzer, the diagnostic engine generates the working diagnosis. The care engine determines a treatment plan based upon said working diagnosis.
Subjects received 3 doses of Engerix vaccine at Months 0, 2 and 6. The vaccine was administered intramuscularly into the deltoid region of the non-dominant arm.
In this study, we developed a microfluidic device that is able to monitor cell biology under continuous PM2.5 treatment. The effects of PM2.5 on human alveolar basal epithelial cells, A549 cells, and uncovered several significant findings were investigated. The results showed that PM2.5 exposure did not lead to a notable decrease in cell viability, indicating that PM2.5 did not cause cellular injury or death. However, the study found that PM2.5 exposure increased the invasion and migration abilities of A549 cells, suggesting that PM2.5 might promote cell invasiveness. Results of RNA sequencing revealed 423 genes that displayed significant differential expression in response to PM2.5 exposure, with a particular focus on pathways associated with the generation of reactive oxygen species (ROS) and mitochondrial dysfunction. Real-time detection demonstrated an increase in ROS production in A549 cells after exposure to PM2.5. JC1 assay, which indicated a loss of mitochondrial membrane potential (ΔΨm) in A549 cells exposed to PM2.5. The disruption of mitochondrial membrane potential further supports the detrimental effects of PM2.5 on A549 cells. These findings highlight several adverse effects of PM2.5 on A549 cells, including enhanced invasion and migration capabilities, altered gene expression related to ROS pathways, increased ROS production and disruption of mitochondrial membrane potential. These findings contribute to our understanding of the potential mechanisms through which PM2.5 can impact cellular function and health.
NIRS Neurofeedback training of frontal and pre frontal lobes activation. The intervention consist of 24 NIRS neurofeedback sessions over 12 weeks, 2 sessions per week.