anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a composition for enhancing sanitation of an oral cavity comprising a natural medicinal herb extract as an active ingredient. More particularly, the present invention relates to a composition for enhancing sanitation of an oral cavity, comprising extract of at least one selected from Impatiens balsamina L. and Xanthii Fructus and a natural medicinal herb extract of Scutellaria baicalensis Georgi / Paeonia suffruticosa as an active ingredient for halitosis-inducing microorganisms and mucous membrane infection. The composition according to the present invention provides excellent effects of preventing and treating periodontal diseases, preventing dental caries and eliminating halitosis and effects of a natural antibiotic and preservative. Particularly, the composition according to the present invention enhances a synergic effect against halitosis-generating microorganisms and oral cavity mucous membrane infection-inducing microorganisms, an effect of inhibiting plaque formation and an effect of alleviating gingivitis through an adequate combination of naturally occurring material complexes providing antibacterial and antifungal activities. In addition, the composition uses no alcohol to prevent oral cavity dryness. Further, the composition has an effect of preventing oral cavity mucous membrane infection (oral candidiasis) and vaginal infection that children or women frequently experience.
As expected with any B-cell depleting therapy, decreased immunoglobulin levels were observed. Decrease in immunoglobulin M (IgM) was reported in 7.7% of patients treated with KESIMPTA compared to 3.1% of patients treated with teriflunomide in RMS clinical trials [see Adverse Reactions (6.1)]. Treatment was discontinued because of decreased immunoglobulins in 3.4% of patients treated with KESIMPTA and in 0.8% of patients treated with teriflunomide. No decline in immunoglobulin G (IgG) was observed at the end of the study. Monitor the levels of quantitative serum immunoglobulins during treatment, especially in patients with opportunistic or recurrent infections, and after discontinuation of therapy until B-cell repletion. Consider discontinuing KESIMPTA therapy if a patient with low immunoglobulins develops a serious opportunistic infection or recurrent infections, or if prolonged hypogammaglobulinemia requires treatment with intravenous immunoglobulins.
Faecal incontinence is a devastating condition with huge impact on quality of life. Sacral Nerve Stimulation (SNS) has since 1995 been a treatment option for patients not obtaining satisfactory continence result with standard non-surgical treatments. SNS is electrical stimulation of the sacral nerve root(s2,3 or 4). Stimulation of this nerve roots results in improved continence. The mechanism of action is at present not well described.

Standard the neuromodulator (pacemaker) stimulate with Frequency 14 Hz, pulse width 210 mic.sec. and amplitude set at sensory threshold. One study by SM. Koch et all confirms that subsensory stimulation can be effective. At present there is no doubled blinded study's to confirm this theory of effective sub sensory stimulation.

The aim of this study is to determine if subsensory stimulation will be as effective as stimulation with amplitude at sensory threshold. This will be investigated in 20 patients who have had at least a reduction in incontinence episodes or Wexner inc. score of 75 % between preimplantation and latest follow up. The patients will be randomized to three different amplitudes. 1: amplitude set at sensory threshold. 2: 75% of sensory threshold. 3: 50% of sensory threshold. The order of the three settings will be random and in a double blinded manner. The interval between these three pacemaker settings is four weeks. Patients serve as there own controls. Stimulation frequency (14 Hz) and pulse width (210 mic-sec) will remain fixed.

Evaluation will be by means of 4 week bowel habit diary and questionnaires (Wexner inc. score / St. Marks Score / Wexner constipation score / Altomares OD-score / IBS-score/ Rockwood FIQoL -score). All patients will be evaluated with anorectal measurements (sphincter strength and anorectal volume measurements) before any changes of stimulation amplitude.
PURPOSE:To provide an incense stick having lustrous colored coating film having gold color, silver color, etc., on the outer circumference. CONSTITUTION:An air-passing hole 3 is longitudinally extended at the center of an incense stick 2. The outer circumference of the incense stick is colored by applying a colored coating film 1 having lustrous gold color, silver color, etc. The application of the colored film is carried out either by applying a color paint or by wrapping the surface with a colored sheet or foil. The incense stick is produced by extruding an incense stick raw material through a die, drying the extruded hollow tube after cutting to a prescribed length and forming a colored film on the outer circumference of the tube. The die for the extrusion of the incense stick is produced by forming a stick-extrusion hole 5 on a die plate 4, extending a mandrel-supporting plate 6 provided with stick-inlet holes 7, 7, 7 in the direction of the diameter of the extrusion hole and fixing a hollow- forming mandrel 8 at the center of the mandrel-supporting plate 6 in a state suspended at the center of the extrusion hole directing the outlet port of the extrusion hole 5 downward.
The invention discloses long-chain non-coding RNA CYP1B1-AS1, the nucleotide sequence of which is shown AS SEQ ID NO. 1. The invention also discloses a CYP1B1-AS1 lentivirus over-expression vector, a lentivirus stable expression cell strain and application thereof in preparing a breast cancer diagnosis kit, a medicament for preventing or treating breast cancer or a prognosis product. CYP1B1-AS1 can obviously down-regulate expression in breast cancer, and can be used AS a diagnosis marker of the breast cancer. The expression level of CYP1B1-AS1 is related to prognosis of patients, and can be used AS a prognosis marker of breast cancer. Up-regulating CYP1B1-AS1 can inhibit malignant progress of breast cancer cells, and has application value AS a gene therapy target. Upregulation of CYP1B1-AS1 expression can increase sensitivity of breast cancer cells to chemotherapeutic agents. The invention can be used for the preparation of products such as diagnosis and treatment related to breast cancer, improvement of targeted drug sensitivity and the like, and has a certain clinical transformation prospect.
Stroke is a leading cause of death and the survivors are often left with severe disability. Transient ischemic attack (TIA) is an episode of neurological dysfunction, but unlike stroke, the neurological deficits resolve completely within 24 hours. TIA and stroke share the same common underlying cause, and patients with a TIA are at high risk for developing a subsequent stroke. Atrial fibrillation (AF) is the most common cardiac arrhythmia and is recognized as the cause of around 25% of all strokes. The prevalence of AF rises with age, and it is estimated, that approximately 5-10% of all subjects over the age of 80 years has either persistent or paroxysmal AF. Regardless of the AF subtype the risk for stroke is the same, and oral anticoagulation therapy is recognized as a superior treatment of AF related stroke/TIA.

The goal of this project is to extend the normal workup of patients with TIA with a thorough heart monitoring program. This includes 72-hours ambulatory electrocardiogram and insertion of an implantable loop recorder (ILR). The ILR is small device implanted in the subcutaneous tissue in the left thoracic region. The device continuously monitors for arrhythmias in a period up to 3 years. The 150 patients enrolled will also receive an ultrasound examination of the heart and arteries of the neck and a computed tomography scan of the heart. Lastly, biomarkers with known or suspected association with stroke and AF will be measured.

The primary goal of the study is to determine, whether or not an extended heart monitoring program with an ILR will identify more patients with AF as the underlying cause of TIA. This can have enormous advantages for the patient, because the treatment with oral anticoagulation therapy reduces the risk of subsequent stroke by approximately 40% compared to conventional antiplatelet therapy. Secondly, the study means to identify patients at high risk for developing AF assessed with ultrasound, computed tomography and novel biomarkers.
Prolonged consumption of foods containing toxic metals can elevate the risk of noncommunicable diseases, including chronic kidney disease of uncertain etiology (CKDu). Despite the increasing number of CKDu cases in Maradankulama and Mahakanadrawa Grama Niladhari Divisions (GN) in Sri Lanka, no prior studies have examined the accumulation of heavy metal(loid)s and their potential association with CKDu prevalence. Furthermore, there is an absence of comprehensive analyses using chemometric techniques such as PCA and hierarchical studies regarding CKDu and heavy metal contamination in Sri Lanka. This study aims to provide initial insights into the accumulation and potential pathways of toxic metals in staple foods within local diets and their subsequent presence in the agricultural environment of examined GNs. Cr, Cd, As, and Ni concentrations in analyzed foods were within permissible limits (MPLs), whereas Pb levels exceeded MPLs in rice (Oryza sativa), gotukola (Centella asiatica), lime (Citrus crenatifolia), and inland fish (Etroplus suratensis). High target hazard quotient (THQt) values in polished rice suggest possible health risks with prolonged intake. Hierarchical analysis suggested a common source of Pb accumulation. PCA and hierarchical clustering revealed the intricate connection between As and Cd, with their concurrent clustering in samples suggesting a potential common origin. This indicates that while individual concentrations comply with acceptable standards, the potential synergistic effects of Cd and As accumulation might pose elevated health risks. Further, the gut tissues of inland fish exhibited pronounced metal concentrations and significant (p < 0.05) positive correlations with toxic metals in the tank sediments suggesting a diet-based bioaccumulation pathway through sediments.
Primary (n=40) and secondary participants with chronic HCV infection (approx. n=50%\*100) will be treated with 'Sofosbuvir/ledispasvir fixed dose combination (SOF + LDP) for 12 weeks. Participants in Group C who have evidence of HCV re-infection will be offered re-treatment with SOF + LDP for 12 weeks.
BACKGROUND: Despite advances in breast carcinoma therapies, drug resistance mechanisms as anti-apoptosis and anti-pyroptosis limit the application of these therapies. This work assesses the immunohistochemical (IHC) expression of Caspase1 and EGFR in breast carcinoma and analyzes their clinicopathological associations as prognostic markers and potential therapeutic targets. Caspase1/EGFR expression patterns are utilized to specify breast carcinoma patients who may benefit from these therapies.
METHODS: After reviewing the hematoxylin and eosin-stained slides and the routine breast carcinoma IHC stains (estrogen receptors, progesterone receptors, HER2/NEU, Ki-67) by two pathologists and preparation of tissue microarray blocks, anti-Caspase-1 and EGFR IHC staining was performed using Horseradish Peroxidase (HRP) technique. Intensity and percentage-based scoring was applied dividing the 153 included breast carcinomas into Caspase1-negative and positive expression groups; and EGFR low and overexpression groups. Groups were statistically analyzed in relation to age, tumor size, histological and molecular subtype, grade, nodal status, metastasis/recurrence, TNM stage and Ki-67 proliferation index. Kaplan-Meier's analysis was used to compare disease-free survival (DFS) and overall survival (OS). Combined patterns based on Caspase1 and EGFR expression status were created to stratify patients into prognostic groups.
RESULTS: Caspase1 was positive in 54.2% of breast carcinomas and its positivity was significantly associated with smaller tumor size, absence of metastasis/recurrence, luminal A and B molecular subtypes and longer OS (p<0.05). EGFR overexpression was detected in 32.7% of carcinomas and was significantly associated with larger tumor size, TNBLBC and a shorter OS (p<0.05). Caspase1-negative/EGFR-overexpression pattern comprised 14.4% of carcinomas and had the worst prognostic associations including larger tumor size, metastasis/recurrence, TNBLBC subtype and shortest OS (p=0.002, 0.002, 0.004 and ≤0.001 respectively).  Conclusions: Combined Caspase1/EGFR IHC expression may provide a tool for selection of patients who benefit from combined EGFR-inhibitors with miR-155-5p down-regulators or photodynamic therapy via induction of apoptosis/pyroptosis in EGFR-overexpression carcinomas through enhanced Caspase1 signaling.
A system and a method for marking, identifying and managing medical devices are provided. The system includes an input module, a marking and identifying module, a user operating module and a server module. The input module is configured to input a plurality of medical device information. The marking and identifying module is connected to the input module for marking or identifying a plurality of medical devices corresponding to the medical device information, and generating a marking result or an identifying result respectively. The user operating module is connected to the marking and 
identifying module for displaying a graphical interface operational to a user based on at least one of the marking result and the identifying result. The server module is connected to at least one of the marking and identifying module and the user operating module for receiving at least one of the marking result, the identifying result and the graphical interface to generate a database. Thereby, the medical device management can be achieved in an effective and safe manner.
WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Patients with early Leber’s disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy.

Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely.

Anaphylactic shock and death have been reported after parenteral Vitamin B12 administration. An intradermal test dose is recommended before cyanocobalamin injection is administered to patients suspected of being sensitive to this drug.

This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal ‘‘Gasping Syndrome’’ in premature infants.
The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may include one or more DNA sequences encoding mammalian proteins and at least one promoter capable of directing the expression of recombinant proteins in an aloe plant. The present inventions also provide methods for constructing and reproducing a transgenic aloe plant. The present inventions include methods for transfection of an aloe plant with several genes of interest simultaneously. The aloe plant production methods of the inventions may provide the potential to inexpensively and more safely mass-produce some biologically active compounds including biopharmaceuticals for disease therapy, diagnosis and prevention, and is more accessible to the less affluent countries. The aloe plant production methods may also produce proteins for cosmetics.
FIELD: organic chemistry, heterocyclic compounds, medicine, oncology. SUBSTANCE: invention relates to novel crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl)-uracil and also to complex compounds of this form with 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine or licorice roots extract (Radices Glycyrrhizae). By its indices this form differs from the early known modification of this compound and shows the enhanced antitumor activity and used in medicine. New form shows the enhanced stability and it can form stable molecular complexes with biologically active compounds that elicit similar properties. EFFECT: enhanced activity and stability of synthesized compounds. 10 cl, 14 dwg, 2 tbl, 4 ex
The cooperative learning method is structured on students\&#39; communication and interaction with each other. Many outcomes such as increasing students; academic success, critical thinking, verbal communication, taking responsibility for learning, improving their ability to take responsibility, increasing their ability to evaluate, and being open to feedback are among the benefits of cooperative learning. In cooperative learning, the basic principle is that students form groups and share their knowledge within each group regarding the basic knowledge and skills they want to learn, and then the groups interact with each other. With this method, students can take on learning responsibilities themselves, and they can also develop their knowledge sharing, collaboration and leadership skills within the group. Therefore, cooperative learning is an effective training method by strengthening self-directed learning, as well as supporting effective communication within team members. In a study conducted with nursing students using cooperative learning, it was observed that higher success, more positive relationships between students, and more psychological adaptation developed compared to traditional education methods. In international studies investigating the use of active learning strategies in nursing education, it has been concluded that collaborative learning is of great importance in transforming critical thinking ability, clinical performance, knowledge adequacy and nursing knowledge into clinical skills. In a similar vein, it has been emphasized that cooperative learning is an effective teaching method in improving the knowledge and psychomotor skill levels of nursing students regarding local drug applications and increasing the permanence of information. This study will focus on students; learning of knowledge and skills regarding enteral nutrition through cooperative learning method. A more memorable learning is aimed by students forming groups and transferring information both within and between groups.
The present invention relates to mesoporous calcium phosphate-citrate nanoparticles, optionally comprising a lipid membrane, and pharmaceutical compositions thereof. The present invention further relates to a method of synthesizing the mesoporous calcium phosphate-citrate nanoparticles. The present invention relates to their use as drug delivery system. The present invention further relates to medical uses as bone or teeth cement, bone material or taste or non-taste masked carrier or delivery system. The present invention relates to the use of the mesoporous calcium phosphate-citrate nanoparticles in the diagnosis and/or treatment of cancer. The present invention further relates to the use of the mesoporous calcium phosphate-citrate nanoparticles in fertilizer or absorber of metal ions from wastewater and/or water.
Long-term aerobic training are associated with improved motor learning. Recent studies have shown that even a single bout of moderate or high ıntensity aerobic exercise can lead to immediate improvements on motor learning. On the other hand, there is still insufficient knowledge about whether aerobic exercise should occur before or after motor practice and what the intensity of aerobic exercise should be. In this study, the ınvestigators examined the effects of a single bout of low and moderate intensity aerobic exercise applied before or after motor practice on golf putting task. Additionally, the ınvestıgators evaluated the effects of sleep quality on motor learning and the acute effects of the exercise on cognition. 75 young adults were divided into five groups: two groups that did low or moderate intensity aerobic exercise before motor practice (LOW-MP, MOD-MP), two groups that did aerobic exercise after motor practice (MP-LOW, MP-MOD), and non-exercise control group. The acquisition practice consisted of six blocks of ten golf puttings. The retention was also evaluated both 1 day and 7 days after the experimental day with one block each. The putting performance was measured with accuracy and consistency error scores were computed for each acquisition and retention block. The sleep quality of the night before and the experimental day were evaluated using the Richard Campbell Sleep Scale.
It has been found that arm and leg cycling is similar to walking in terms of the muscle activation patterns, joint ranges of motion, and neural pathways activated. Another advantage of arm and leg cycling is that it involves coordination of all four limbs in a rhythmic movement. This may be particularly beneficial given previous findings that arm movement contributes to the activation of leg muscles during walking in humans. This is achieved with interconnected neural pathways that link the arms to the legs. These neural interlimb connections remain intact in stroke victims, such that maximizing the contribution of the arms to the legs may increase coordination for walking.

Thus, the objective of this research is to determine if arm and leg cycling can be used to increase the strength of inter-limb connections and if this helps to improve walking ability in a post-stroke population. 15-20 participants will be recruited to participate in a five week training intervention where measures will be taken before and after the intervention to assess efficacy. Arm and leg cycling could provide a novel method to improve inter-limb coupling and walking ability. These outcomes would directly impact the health and quality of life for those who have suffered a stroke.