anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a carrier for serodiagnosis, etc. which can be preserved for a long  period of time and has excellent characteristics by contg. anionic or nonionic surfactants in an aq. soln. of gelatin, water soluble polysaccharides and sodium polymetaphosphate prior to controlling of said soln. to a specific pH range. CONSTITUTION:An aq. soln. of gelatin, water soluble polysaccharides such as gum  arabic and sodium polymetaphosphosphate (in other words, only water is used, without  making combination use of org. solvents) is maintained at temp. higher than the gelling temp. of the gelatin and a soln. of anionic or nonionic surfactants are added thereto; thereafter a soln. of acetic acid, etc. is dropped to the soln. under stirring to adjust  2.5-6.0pH and to form particles. According to the conditions such as pH and compsns.  of raw materials, grain sizes can be controlled to desired values. After the formation  of the particles, the soln. is cooled and when the temp. drops to <=10 deg.C, aldehyde crosslinking agents are added to the soln. to insolubilize the same. The particles are centrifugally sepa rated and washed, whereby the carrier is obtained. This carrier is obtainable in good yields and with uniform properties, and is preservable for a long  period of time. The carrier bound with antigens or antibodies is stable without liberation of the antigens, etc. even when preserved by freeze drying.
The present invention provides compound beriberi liquid which relates to a medicine agent for treating different skin tinea, such as beriberi, hand tinea, tinea pedis, tinea cruris, tinea corporis, etc. The present invention is prepared in order to mainly solve the problem that the existing various ointments for treating beriberi have long therapeutic course with medicine liquid, poor therapeutic effect and easy recurrence. A recipe mainly comprises dahurian angelica roots, borneol, white alum, radix sileris, red peony roots, scutellaria roots, Sichuan capsicum, stemona roots and herba schizonepetae. The medicines are soaked by alcohol and filtered to form the compound beriberi liquid. The present invention has the advantages that the effectiveness rate of beriberi treatment achieves 100%, the cure rate achieves 98%, and generally, the beriberi can be cured in five to seven days. Besides, the present invention has no side effect and difficult recurrence.
OBJECTIVE: To verify the administration of a new nano delivery system coated with Tirofiban on preventing early thrombosis in vein graft.
METHODS: Forty New Zealand white rabbits were randomly divided into five groups with eight rabbits in each group. The rabbits of all groups underwent jugular vein transplantation, except group I with only neck opening and closing operation. Vein grafts of group II were preprocessed by intravenous injection of normal saline; group III were preprocessed by tirofiban alone; group IV were preprocessed by unloaded nanoparticles of PLGA-PEG; group V were preprocessed by PLGA-PEG coated with tirofiban. Coagulation and platelet function of peripheral and vein graft blood were detected at 1, 2, 4, 12 h and 1, 3, 7, 10, 14 days after operation. Patency rate of vein graft and blood flow index were measured by vascular ultrasound at third, seventh, 10th, and 14th days after operation; two rabbits in each group were randomly sacrificed at the corresponding time of detection. Pathological differences of vein grafts were observed by HE stainin.
RESULTS: The patency rate of vein grafts in group V was significantly higher than that in group II to IV. The platelet and platelet aggregation rate in group V were inhibited in vein graft blood significantly. The post-operative PT and APTT in vein graft blood in group V were increased obviously while the FBG, D-dimer and FDP were significantly inhibited. Except group I, the lumen loss rate of vein grafts in group V was significantly lower than that in other groups, and vein graft blood in group V had a significant lower expression of platelet P-selectin and GP IIb/IIIa receptor than that in other groups.
CONCLUSION: This study proves that PEG-PLGA coated with tirofiban can effectively prevent early vein graft stenosis from thrombosis by inhibition of platelet function, coagulation function.
Valid for the first 24 weeks of the study. Arm 2a; Omega-3, (1000 mg fill weight per capsule) containing omega-3 ethyl ester concentrate with a high proportion of DHA.
Usual management of heart failure. The sST-2 level will be blunted.
Healthy male participants of 18 to 45 years of age received a single dose of MK-8521 100μg in the first treatment period, and MK-8521 300μg in the second treatment period. There was a minimum of a 7-day washout period between treatment periods.
Anthelmintics. A single dose of Albendazole (400mg) at month 0 and single dose of Vitamin C (500 mg) at 3, 6, 9 and 12 months.
BACKGROUND: National and international guidelines on frailty assessment and management recommend frailty screening in older people. This study aimed to determine how Brazilian healthcare professionals (HCPs) identify and manage frailty in practice.
METHODS: An anonymous online survey on the assessment and management of frailty was circulated virtually through HCPs across Brazil.
RESULTS: Most of the respondants used non-specific criteria such as gait speed (45%), handgrip strength (37.6%), and comprehensive geriatric assessment (33.2%). The use of frailty-specific criteria was lower than 50%. The most frequently used criteria were the Frailty Index (19.1%), Frailty Phenotype (13.2%), and FRAIL (12.5%). Only 43.5% felt confident, and 40% had a plan to manage frailty. In the multivariate-adjusted models, training was the most crucial factor associated with assessing frailty, confidence, and having a management plan (p < 0.001 for all). Those with fewer years of experience were more likely to evaluate frailty (p = 0.009). Being a doctor increased the chance of using a specific tool; the opposite was true for dietitians (p = 0.03). Those who assisted more older people had a higher likelihood of having a plan (p = 0.011).
CONCLUSION: Frailty assessment was heterogeneous among healthcare professions groups, predominantly using non-specific criteria. Training contributed to frailty assessment, use of specific criteria, confidence, and having a management plan. This data informs the need for standardized screening criteria and management plans for frailty, in association with increasing training at the national level for all the HCPs who assist older people.
Cocaine has been described in literature to be primarily metabolized and inactivated by non-enzymatic ester hydrolysis and hepatic carboxylesterase, and also by plasma cholinesterase, hepatic carboxylesterase and CYP3A4 [see Clinical Pharmacology (12.3)] . Pharmacokinetics of COCAINE HYDROCHLORIDE nasal solution in patients with reduced plasma cholinesterase activity has not been studied. 

Genetic abnormalities of plasma cholinesterase (e.g., patients who are heterozygous or homozygous for atypical plasma cholinesterase gene), disease conditions such as malignant tumors, severe liver or kidney disease, decompensated heart disease, infections, burns, anemia, peptic ulcer, or myxedema or other physiological states such as pregnancy may lead to reduced plasma cholinesterase activity. Patients with reduced plasma cholinesterase (pseudocholinesterase) activity may have reduced clearance and increased exposure of plasma cocaine after administration of COCAINE HYDROCHLORIDE nasal solution.

Since cocaine is metabolized by multiple enzymes, the effect of reduced plasma cholinesterase activity on cocaine exposure may be limited. No dosage adjustment of COCAINE HYDROCHLORIDE nasal solution is needed in patients with reduced plasma cholinesterase. Monitor patients with reduced plasma cholinesterase activity for adverse reactions such as headache, epistaxis, and clinically-relevant increases in heart rate or blood pressure.
The present disclosure provides systems and methods for ultrasound image processing. The methods include obtaining a first ultrasound image and a second ultrasound image of a target subject. The first ultrasound image and the second ultrasound image include a linear interventional device within the target subject. The methods include identifying one or more line segments in the second ultrasound image by processing the second ultrasound image using a first line detection algorithm. For each of the one or more line segments, the methods include determining a corrected line segment by processing a target region in the second ultrasound image corresponding to the line segment using a second line detection algorithm. The methods include generating a fused ultrasound image of the first ultrasound image and the second ultrasound image based on one or more corrected line segments corresponding to the one or more line segments.
OBJECTIVE: This study aimed to assess the impact of combined moxibustion therapy and Gua sha on enhancing functional independence, reducing fall risk, and alleviating pain in patients undergoing post-rehabilitation for multiple cerebral infarctions.
METHODS: In a prospective clinical trial, 67 patients diagnosed with multiple cerebral infarctions (age range: 40 to 93 years) were enrolled. Baseline health characteristics included a median hospital stay of 10 days, prevalent medical conditions such as hypertension (64.18%), and various comorbidities like spondylosis (17.91%) and heart disease (14.93%). Patients received moxibustion treatment daily for 20-30 minutes on specific acupoints of the upper and lower extremities. Additionally, Gua sha therapy targeting the the head, back, chest, abdomen, and selected acupoints was administered twice a week with an interval of 3 to 4 days. Assessments included Barthel Index (BI) for functional independence, Morse Fall Scale (MFS) for fall risk, and Visual Analogue Scale (VAS) for pain intensity before and after the intervention.
RESULTS: After one week of rehabilitation, significant improvements were observed in the patient's functional independence, as indicated by a median BI score of 100 (IQR: 95-100), compared to the pre-rehabilitation median score of 95 (IQR: 90-100). The MFS score also showed a significant decrease after rehabilitation, with a median score of 35 (IQR: 35-45) compared to the pre-rehabilitation median score of 45 (IQR: 35-45). Additionally, pain intensity significantly decreased, with a median VAS score of 0 (range: 0-2) after rehabilitation, compared to the pre-rehabilitation median score of 0 (range: 0-3).
CONCLUSION: Combined moxibustion therapy and Gua sha demonstrated positive effects on functional independence, fall risk reduction, and pain alleviation in post-rehabilitation for multiple cerebral infarctions. These findings suggest the potential of moxibustion and Gua sha as complementary interventions in stroke rehabilitation. The observed improvements in functional independence, fall risk, and pain underscore the potential benefits of these therapies for patients with multiple cerebral infarctions. Further exploration could delve into long-term effects, larger-scale trials, and mechanistic studies to elucidate the underlying pathways of efficacy.
BACKGROUND: Papillary thyroid cancer (PTC) progresses slowly and has a good prognosis, while the prognosis is worse if combined with central neck lymph node metastasis at an early stage. The different endoscope approaches may affect the thoroughness of lymph node dissection. This study aimed to compare the clinical efficacy and safety of prophylactic central lymph node dissection(CLND) for cN0 PTC performed via breast and transoral approach versus via breast approach alone.
MATERIALS AND METHODS: A retrospective analysis of the surgical data of 136 patients with stage cN0 PTC was performed from August 2020 to December 2022. Among them, 64 underwent the breast and transoral approach (combined approach group), and 72 underwent the breast approach alone (breast approach group). The relevant indexes of surgery, the number of lymph nodes dissected, the occurrence of postoperative complications, and the cosmetic satisfaction of incision were statistically compared between the two groups.
RESULTS: The operation time of the combined approach group was 156.4 ± 29.8 min, significantly longer than that of the breast approach group, 119.6 ± 55.9 min, and the difference was statistically significant (P<0.05). The two groups of patients were compared in terms of intraoperative bleeding, postoperative drainage, hospitalization time, incision cosmetic satisfaction, and the occurrence of postoperative complications, and the differences were not statistically significant (P>0.05). The total number of lymph nodes retrieved in the central area (10.6 ± 7.1) and the number of positive lymph nodes (4.6 ± 4.9) in the combined approach group were significantly more than those in the breast approach group (7.4 ± 4.8, 1.6 ± 2.7), and the difference was statistically significant (P<0.05). The difference between the two groups in terms of the number of negative lymph nodes was not statistically significant (P>0.05).
CONCLUSIONS: The study demonstrated that choosing the breast combined transoral approach for prophylactic CLND of cN0 PTC could more thoroughly clear the central area lymph nodes, especially the positive lymph nodes, which could help in the evaluation of the disease and the guidance of the treatment, while not increasing the postoperative complications. It provides a reference for clinicians to choose the appropriate surgical approach and also provides new ideas and methods for prophylactic CLND in patients with cN0 PTC.
A method of emergency data transmission over a communications network, the network including a user equipment and a base station with an emergency data handling module, the method comprising: the user equipment wirelessly transmitting an emergency indicator to the base station; the emergency data handling module of the base station recognizing an emergency by associating the emergency indicator and related emergency data with an emergency event; the user equipment transmitting the related emergency data wirelessly to the base station with emergency priority based on the emergency event; the base station transmitting the emergency indicator and the related emergency data to a server. The emergency indicator may be transmitted as an uplink transmission request. The emergency data may also be transmitted with emergency priority from the base station to the server. The emergency data handling module may instruct one or more radio bearers for the emergency data with emergency quality label or emergency scheduling label. Suspension of lower priority traffic in the network may also take place to allow transmission of emergency priority traffic to maintain acceptable quality and/or delay levels. The emergency data may be transmitted to the user equipment from one or more sensor units, wherein the user equipment acts as a data collector in a local sensing network such as a body area network (BAN). The sensing units may be a medical device to monitor patient health or other sensor device such as a flood/environment/nuclear radiation/temperature etc. monitor. Follow-up measurements may also take place with an associated high priority allocated. The base station may provide a femtocell in a remote sensing environment to act as a home NodeB. The base station may further function as a gateway for direct access to a supporting server via the internet.
PURPOSE: An anionic drug-containing pharmaceutical composition and a method for manufacturing the same are provided to enhance drug stability in blood and body fluids and to improve drug efficiency. CONSTITUTION: A composition for delivering an anionic drug contains an anionic drug as an active ingredient and an anionic lipid and amphiphilic block copolymer. The anionic drug forms an anionic lipid and composite. The composite is sealed inside the micelle structure of the amphiphilic block copolymer. The anionic drug is a nucleic acid substance. A method for manufacturing the composition for an anionic drug delivery comprises: a step of dissolving an anionic drug and anionic lipid in a water soluble organic solvent or mixture solvent of aqueous solution and organic solvent for phase separation; a step of isolating an organic solvent layer; a step of mixing amphiphilic block copolymer in the organic solvent layer to remove the organic solvent; and a step of adding an aqueous solution to the mixture in which organic solvent is removed to make micelle.
A compound of the formula Het-NR-SO2?-Ph?2-A-Ph?1 (COOH)(OH) and tautomic form, salts, solvates, C1-6? alkyl esters and pharmaceutical compositions of the compound. Ph?1 and Ph?2 are benzene rings with the proviso that carboxy and hydroxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A is a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The invention also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.
There is sufficient evidence indicating that keloid is strongly associated with atopic dermatitis (AD) across ethnic groups. However, the molecular mechanism underlying the association is not fully understood. The aim of this study is to discover the underlying mechanism of the association between keloid and AD by integrating comprehensive bioinformatics techniques and machine learning methods. The gene expression profiles of keloid and AD were downloaded from the Gene Expression Omnibus (GEO) database. A total of 449 differentially expressed genes (DEGs) were found to be shared in keloid and AD using the training datasets of GEO (GSE158395 and GSE121212). The hub genes were identified using the protein-protein interaction network and Cytoscape software. 20 of the most significant hub genes were selected, which were mainly involved in the regulation of the inflammatory and immune response. Through two machine learning algorithms of LASSO and SVM-RFE, CCR5 was identified as the most important key gene. Subsequently, upregulated CCR5 gene expression was confirmed in validation GEO datasets (GSE188952 and GSE32924) and clinical samples of keloid and AD. Immune infiltration analysis showed that T helper (Th) 1, 2 and 17 cells were significantly enriched in the microenvironment of both keloid and AD. Positive correlations were found between CCR5 and Th1, Th2 and Th17 cells. Finally, two TFs of CCR5, NR3C2 and YY1, were identified, both of which were downregulated in keloid and AD tissues. Our study firstly reveals that keloid and AD shared common inflammatory and immune pathways. Moreover, CCR5 plays a key role in the pathogenesis association between keloid and AD. The common pathways and key genes may shed light on further mechanism research and targeted therapy, and may provide therapeutic interventions of keloid with AD.
This antiviral agent comprises, as an active ingredient, an extract derived from a microalga Pseudochoricystis ellipsoidea Sekiguchi et Kurano gen. et sp. nov. MBIC11204 strain. The microalga may be cultured in a culture medium comprising sufficient nitrogen or may be cultured in a nitrogen-deficient medium thereafter. The extract is extracted from the microalga with alcohol, hot water, etc. as an extractant. The extract may be extracted from the residue thereof with hot water. The antiviral agent may comprise the extract obtained using one extractant or may comprise a mixture of each of the extracts obtained using multiple extractants.
Patients in the intervention arm will receive a newly developed, 1-page conversation aid/communication tool entitled "Talking to Your Doctor about Diabetes: Are My Current Medicines Still Right for Me?" prior to a scheduled appointment with their PCP. This document will provide brief education about changing risks and benefits of diabetes treatment as patients age, elicit values and preferences regarding treatment, and help direct next conversation steps.
The invention discloses a grape seed extract which consists of the following raw materials in parts by weight: 30-50 parts of grape seeds, 10-16 parts of portulaca grandiflora and 5-9 parts of sweet-clover astragalus. The preparation method comprises the following steps: I. grinding the raw materials according to the proportions in a grinder to 200 meshes for later use; II. adding the grape seeds, portulaca grandiflora and sweet-clover astragalus powder to a supercritical CO2 extractor for extracting, wherein separate temperature is 30-40 DEG C, separate pressure is 9-13MPa, extracting pressure is 20MPa and extracting duration is 3h so as to obtain corresponding volatile oil and liposoluble constituents; III. dipping medicine residue to 10 times of 80% of ethanol at room temperature for 20h after removing the volatile oil and liposoluble constituents, filtering and collecting medicine liquid; then dipping the medicine liquid in 10 times of 80% of ethanol at room temperature for 20h once again and filtering; such repeating for three times; and IV. combining the medicine liquid obtained from the step III and the medicine liquid obtained from the step IV, decompressing and concentrating, recovering ethanol and spray-drying so as to obtain solid dry powder. The grape seed extract disclosed by the invention has a significant curative effect on female irregular menstruation.
The main cause of second-generation antipsychotic (SGA)-induced obesity is considered due to the antagonism of serotonin 2c receptors (5-HT2cR) and activation of ghrelin receptor type 1a (GHSR1a) signalling. It is reported that 5-HT2cR interacted with GHSR1a, however it is unknown whether one of the SGA olanzapine alters the 5-HT2cR/GHSR1a interaction, affecting orexigenic neuropeptide signalling in the hypothalamus. We found that olanzapine treatment increased average energy intake and body weight gain in mice; olanzapine treatment also increased orexigenic neuropeptide (NPY) and GHSR1a signaling molecules, pAMPK, UCP2, FOXO1 and pCREB levels in the hypothalamus. By using confocal fluorescence resonance energy transfer (FRET) technology, we found that 5-HT2cR interacted/dimerised with the GHSR1a in the hypothalamic neurons. As 5-HT2cR antagonist, both olanzapine and S242084 decreased the interaction between 5-HT2cR and GHSR1a and activated GHSR1a signaling. The 5-HT2cR agonist lorcaserin counteracted olanzapine-induced attenuation of interaction between 5-HT2cR and GHSR1a and inhibited activation of GHSR1a signalling and NPY production. These findings suggest that 5-HT2cR antagonistic effect of olanzapine in inhibition of the interaction of 5-HT2cR and GHSR1a, activation GHSR1a downstream signaling and increasing hypothalamic NPY, which may be the important neuronal molecular mechanism underlying olanzapine-induced obesity and target for prevention metabolic side effects of antipsychotic management in psychiatric disorders.
PURPOSE: To provide a bone-inductive composition of making possible to medically inject and to use for repairing the bone of human and other mammals by containing a water suspension made of a primary fibrous atheropeptide collagen and at least partially refined bone forming gene. CONSTITUTION: Deinorganic-bone extracts (OF) of nonfibrous protein is made soluble by an acid. Beside, the skin preparation of mammal such as a cow and the like is dispersed in a water medium such as HCl and the like, and made soluble by a proteinases such as a pepsin and the like, and finally condensed so that the solution of substantially pure atheropeptide collagen (CIS) is prepared. Next, CIS and OF are mixed so as to become 300:1 of collagen weight ratio from 5:1 of a normal ratio against OF, and then the above both are coprecipitated by enhancing the pH value of solution to be at about 6.5-8.5 by using a buffer solution containing 0.2M of a phosphoric acid. Obtained sediment is further dispersed and it is suspended again in an injectable medium with a desirable concentration.  Accordingly, this water suspension becomes an effective injection-possible preparation for repairing bone trouble.