anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In adipose tissue, reduced expression of the glycerol channel aquaporin 7 (AQP7) has been associated with increased accumulation of triglyceride. The present study determines the relative protein abundances of lipolytic enzymes, AQP7, and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in paired mesenteric and omental visceral adipose tissue (VAT) and abdominal and femoral subcutaneous adipose tissue (SAT) in women with either normal weight or upper-body obesity. No differences in the expression of hormone-sensitive lipase (HSL) or AQP7 were found between the two groups in the four depots. The expression of adipocyte triglyceride lipase (ATGL) and HSL were higher in omental VAT and femoral SAT than in mesenteric VAT in both groups of women. Similarly, AQP7 expression was higher in omental VAT than in mesenteric VAT. The expression of PEPCK-C was lower in omental VAT than in femoral SAT. No correlation between the expression of AQP7 and the mean adipocyte size was observed; however, the expression of PEPCK-C positively correlated with the mean adipocyte size. In conclusion, a depot-specific protein expression pattern was found for ATGL, HSL, AQP7, and PEPCK-C. The expression pattern supports that the regulation of AQP7 protein expression is at least in part linked to the lipolytic rate. Furthermore, the results support that the synthesis of glycerol-3-phosphate via glyceroneogenesis contributes to regulating triglyceride accumulation in white adipose tissue in women.
A prescription for conceiving boys is orally by a female for five days before the intercourse of a couple, and has the advantages of high accuracy, safety and reliability. Chinese angelica, Boswellia carteri and Aplotaxis auriculata are mixed according to certain proportions, and are decocted to obtain a first decoction, and the first decoction is once taken by the female on the first day of the period. Radix Astragali, Radix Codonopsis, Ligusticum wallichii, Chinese magnoliavine, Peach Seed, myrrh, licorice and Fructus Aurantii are mixed according to certain proportions and are decocted to obtain a second decoction, and the second decoction is once taken by the female on the second day of the period. Radix Codonopsis, Fructus Aurantii, Immature Bitter Orange, Radix Aucklandiae, Chinese Eaglewood, myrrh, Radix Astragali and white peony root are decocted to obtain a third decoction, the third decoction is once taken by the female on the third day of the period, and the third decoction is also once taken by the female on the fourth day of the period. Radix Astragali, Radix Codonopsis, myrrh, licorice, Immature Bitter Orange, Fructus Aurantii, Radix Aucklandiae, Rhizoma Polygonati Odorati and white peony root are mixed according to certain proportions and are decocted to obtain a fourth decoction, and the fourth decoction and the kernels and the skins of two walnuts are once taken together by the female on the fifth day of the period. The prescription is ancestral, and has the characteristics of clinical application success rate of above 95%, safety, reliability, body building, miscarriage preventing and qi protecting.
Disclosed herein is a process for preparing magnesium and magnesium hydroxy salts of proton pump inhibitors (PPI) such as omeprazole, hydroxy omeprazole, s-omeprazole (esomeprazole), r-omeprazole, pantoprazole, lanzoprazole, leminoprazole, rabeprazole, tenatoprazole, mixtures thereof or respective isomers thereof. The process can be used to prepare magnesium salts of PPIs. In particular the process can also be used to prepare the magnesium hydroxy salts of PPIs which have the formula: (PPI-)x.Mg2+(OH-)2-x.(H2O)z wherein PPI is a proton pump inhibitor, x is 0.0001 to 1.9999, and z is 0 to 10, preferably 0 to 5. Compositions of the salts of the PPIs disclosed herein including pharmaceutical compositions are also disclosed. The magnesium and magnesium hydroxy salts of proton pump inhibitors disclosed herein can be used in the treatment of gastrointestinal disorders such as Ulcus ventriculi, Ulcus duodeni, gastritis, gastric ulcer, duodenal ulcer, irritable bowel owing to an increased production of acid or as a result of medicaments, GERD, Crohn's disease or IBD.
INTRODUCTION: Training in clinical cardiac electrophysiology (CCEP) involves the development of catheter handling skills to safely deliver effective treatment. Objective data from analysis of ablation data for evaluating trainee of CCEP procedures has not previously been possible. Using the artificial intelligence cloud-based system (CARTONET), we assessed the impact of trainee progress through ablation procedural quality.
METHODS: Lesion- and procedure-level data from all de novo atrial fibrillation (AF) and cavotricuspid isthmus (CTI) ablations involving first-year (Y1) or second-year (Y2) fellows across a full year of fellowship was curated within Cartonet. Lesions were automatically assigned to anatomic locations.
RESULTS: Lesion characteristics, including contact force, catheter stability, impedance drop, ablation index value, and interlesion time/distance were similar over each training year. Anatomic location and supervising operator significantly affected catheter stability. The proportion of lesion sets delivered independently and of lesions delivered by the trainee increased steadily from the first quartile of Y1 to the last quartile of Y2. Trainee perception of difficult regions did not correspond to objective measures.
CONCLUSION: Objective ablation data from Cartonet showed that the progression of trainees through CCEP training does not impact lesion-level measures of treatment efficacy (i.e., catheter stability, impedance drop). Data demonstrates increasing independence over a training fellowship. Analyses like these could be useful to inform individualized training programs and to track trainee's progress. It may also be a useful quality assurance tool for ensuring ongoing consistency of treatment delivered within training institutions.
A blend of Bifidobacterium and Lactobacillus will be taken as a capsule once daily for 12 weeks by subjects in the group receiving this supplement (group is unknown, double-blinded). All subjects will participate in the same behavioral lifestyle intervention. In addition, blood tests will be performed.
The invention discloses a traditional Chinese medicine composition for activating spleen and promoting digestion of children, which mainly comprises the following medicinal materials: stir-fried rhizoma atractylodis, fructus amomi, clove, galangal, pepper, dried orange peel, five-finger wild peach, burnt medicated leaven and feverfew. The composition slowly releases medicinal properties by virtue of Chinese medicinal fragrance, and is absorbed by human respiratory system to achieve the effects of activating spleen and resolving food stagnation, and promoting appetite and spleen and stomach. Furthermore, the inventor performs multiple times of preparation on the medicine and the required amount, and finally obtains safe and effective prescription application for clinical use. Accordingly, the inventor designs a corresponding infant spleen-enlivening digestion-promoting sachet and establishes a preparation method thereof. Spleen and stomach are good for transportation, so qi and blood are active, and qi and blood are nourished and nourished, and qi and blood are nourished, so healthy qi is sufficient, and the disease is not caused. In conclusion, the invention is safe and effective, simple in preparation, convenient to use, good in compliance, more acceptable and loved by children and parents, and easy to widely popularize.
Neck pain is a musculoskeletal condition with a high prevalence that may affect the physical, social, and psychological aspects of the individual, contributing to the increase in costs in society and business. Neck pain was significantly associated with repetitive movement, activities that require lifting and moving loads, and being in sitting and leaning positions.Non specific neck pain is a multifactorial and very common condition in adult individuals, traditional acupuncture (TA) and laser puncture (LP) may be treatment options for certain individuals in such a condition. The laser will be placed at the specific acupuncture points: Tianzhu, Fengchi, Jianjing, and Jianzhongshu . Because ultrasound can deliver vibration energy to soft tissues noninvasively, ultrasound has been applied to diagnostic imaging and therapeutic applications. To use ultrasound for acupoint stimulation, a stimulation device was developed using focused ultrasound. The application of an ultrasound stimulus to the acupuncture meridian system has been found safe and effective in many common clinical entities. The Sonicator head is applied to the chosen location as in standard ultrasound therapy, with a gentle circular motion. forty five patients will be assigned randomly to three groups; experimental group 1 will receive acupoint focused ultrasound, experimental group 2 will receive laserpuncture and the control group will receive conventional treatment three times a week for four weeks.
Compsns contain a polysaccharide capable of being adsorbed differentially on gastro-intestinal mucosa, of mol. wt. >106 and having 1-2 sulphate gps. per mono saccharide unit and an acceptable labelling agent capable of detection. Suitable polysaccharides and Na salts of potato starch amylopectin of mol. wt 6.3 x 107 or 12.5 x 107 contg. 1.6 and 1.8 sulphate gps./glycose residue resp. (e.g. sodium amylosulphate) and the labelling agent is a dye esp. methylene blue or a radionuclide esp. technetium 99.m,I-125 or I-131. Compsns are in form for oral or rectal administration and the labelling agent is detected usually by gastroscope when it is a dye or by isotope scanner or scintillation camera when a radionuclide; gastric ulcers are shown up by the adsorption of polysaccharide the edge of the ulcer.
Sympathetic innervation of brown adipose tissue (BAT) controls mammalian adaptative thermogenesis. However, the cellular and molecular underpinnings contributing to BAT innervation remain poorly defined. Here, we show that smooth muscle cells (SMCs) support BAT growth, lipid utilization, and thermogenic plasticity. Moreover, we find that BAT SMCs express and control the bioavailability of Cxcl12. SMC deletion of Cxcl12 fosters brown adipocyte lipid accumulation, reduces energy expenditure, and increases susceptibility to diet-induced metabolic dysfunction. Mechanistically, we find that Cxcl12 stimulates CD301+ macrophage recruitment and supports sympathetic neuronal maintenance. Administering recombinant Cxcl12 to obese mice or leptin-deficient (Ob/Ob) mice is sufficient to boost macrophage presence and drive sympathetic innervation to restore BAT morphology and thermogenic responses. Altogether, our data reveal an SMC chemokine-dependent pathway linking immunological infiltration and sympathetic innervation as a rheostat for BAT maintenance and thermogenesis.
Cases of adult and pediatric patients with overdoses of only oral cetirizine hydrochloride have been reported, some of which resulted in adverse reactions. Adult overdose cases involved patients 18 to 81 years of age receiving oral cetirizine hydrochloride doses of 70 mg to 800 mg (7 to 80 times the maximum recommended dosage of 10 mg/day in adults). The most commonly reported adverse reactions were somnolence and fatigue. Other reported adverse reactions included tachycardia, abdominal pain, nausea, and vomiting. Pediatric overdose cases involved patients 18 months to 15 years of age receiving oral cetirizine hydrochloride doses of 90 mg to 300 mg (9 to 72 times the maximum age recommended dose). The adverse reactions reported included: somnolence, difficulty walking, agitation/irritability, hard to swallow/articulate clearly, tachycardia, vomiting, mydriasis, and elevated creatinine phosphokinase. 

If overdose with QUZYTTIR occurs, treatment should be symptomatic or supportive, taking into account any concomitantly ingested medications. There is no known specific antidote to cetirizine hydrochloride. Cetirizine hydrochloride is not effectively removed by dialysis, and dialysis will be ineffective unless a dialyzable agent has been concomitantly ingested.
The patient will be allowed to 'try-out' the VR system (including all auditory and visual features) for \~5 minutes prior to the start of the procedure. In addition to usual care, consisting of child-life presence and topical analgesics if ordered by the treating medical team, children in the experimental condition will wear the VR HMD plus headphones and hold the VR controller.
<P>PROBLEM TO BE SOLVED: To obtain a composition which has a reduced acidity and is easily used in an oral cavity or is easily taken by peroral route; and to provide a method for decreasing the acidity derived from a substance exhibiting an acidity.  <P>SOLUTION: The composition for oral cavity or peroral route having a reduced acidity is obtained by incorporating thereinto 41-95 pts.wt. at least one compound selected from among 2-amino-2-deoxy-D-glucose, its N-acyl derivatives, and their salts, based on 100 pts.wt. substance exhibiting an acidity. The method for decreasing the acidity derived from the substance exhibiting the acidity is provided by using 2-amino-2-deoxy-D-glucose, its N-acyl derivative, or a salt thereof together with the substance exhibiting the acidity.  <P>COPYRIGHT: (C)2003,JPO
Tomato necrotic ringspot virus (TNRV) was first reported in Thailand in 2011, where it continues to reduce the yield and quality of pepper and tomato crops. Here, we report the complete genome sequence of TNRV isolate chilli-CR derived from next-generation sequencing. The TNRV genome comprises 16,595 nucleotides (nt) on three RNA segments. The L RNA is 8,858 nt, the M RNA is 4,724 nt, and the S RNA is 3,013 nt in length. The genome structure and organization are typical of orthotospoviruses, encoding five proteins, named L, NSm, GNGC, NSs, and N. Pairwise comparison of each genomic RNA segment and its deduced amino acid (aa) sequence showed that TNRV chilli-CR shares 73.6-82.3% nt sequence identity and 81.1-91.9% aa sequence identity with pepper chlorotic spot virus (PCSV). Similar phylogenetic groupings were observed based on each genomic RNA or deduced aa sequence, and with concatenated genomic RNA sequences. The clustering of TNRV and PCSV in all phylogenetic analyses, and the 78.9% overall nt sequence identity observed using the concatenated genomic RNAs suggest that TNRV is a distinct orthotospovirus and that analysis of concatenated orthotospovirus genome sequences will be of value in future phylogenetic studies of this virus group.
Complete national 2006-2014 Medicare data from Part A, B and D will be obtained from CMS. We will use bronchiectasis ICD-9 codes 494.0 and 494.1 to identify patients with bronchiectasis within Medicare. From this identified bronchiectasis cohort, we will exclude patients with cystic fibrosis (ICD-9 codes 277.00-277.09), HIV infection (042), and a history of organ transplant (V42.0, V42.1, V42.6, V42.7, V42.8).
Participants will be eligible for a daily lottery if they have weighed themselves in the previous day on the e-scale. For each day of the study, participants will be informed of the study's randomly-generated winning lottery number and their winnings ($0, $2, $15 or not eligible for lottery due to lack of weighing). Participants will receive $14 per month if they have gained within the recommended monthly range for their BMI category. Otherwise, participants will be specifically notified that they would have received $14 had they had gained within the recommended range for the month, drawing on research showing that loss aversion can be motivating.
PROBLEM TO BE SOLVED: To obtain a therapeutic agent effective for treating hepatitis developing by death of hepatocyte by apoptosis, comprising an antibody against human Fas ligand or its active fragment as an active ingredient. SOLUTION: This therapeutic agent for hepatitis comprises preferably 0.5-70wt.% of an antibody against human Fas ligand or its active fragment as an active ingredient. The dose of the objective therapeutic agent is preferably 0.01-600mg based on the active ingredient per human adult daily. A monoclonal antibody to be specifically reacted with Fas ligand is preferable as the antibody against a human Fas ligand. A monoclonal antibody produced from hybridoma NOKI (FERM BP-5044), for example, may be cited as the monoclonal antibody. When the monoclonal antibody is made into a human type or a chimera type monoclonal antibody, preferably the monoclonal antibody suppresses formation of an antibody against an adventitious protein and effectively acts.
The present disclosure provides compositions and methods comprising human platelet releasate (hPR), a xeno-free media supplement. The disclosure also relates to a cGMP process for the rapid, efficient and large-scale manufacturing of hPR that may be performed in less than 4 hours. The platelet releasate of the current disclosure prevents gelation of growth media alleviating the need for heparin or other anticoagulants. Mesenchymal stem cells expanded in the presence of platelet releasate have demonstrated superior expansion rates and potency compared to commercial supplements including platelet lysates. The releasate has therapeutic and medical applications. The disclosure also relates to compositions and methods related to platelet-rich fibrin.
People with diabetes who develop CVD have worse health outcomes than people without diabetes who develop CVD. Beta-blockers are medications used to treat high blood pressure, angina (i.e., chest pain), arrhythmias, and other CVD conditions. While beta-blockers are effective at treating these conditions, they may also have damaging effects on cholesterol or glucose levels, thereby possibly lessening their ability to prevent CVD events in people with diabetes. It is important to identify which patients may not benefit from receiving beta-blocker medications. Genetic factors may influence how people respond to beta-blocker medications. The purpose of this study is to evaluate the influence of genetic variation on beta-blocker-induced changes in insulin sensitivity, fat breakdown, and heart function in people with type 2 diabetes.

This study will enroll people with type 2 diabetes. At a series of up to three baseline study visits, participants will have a blood collection, a glucose tolerance test, an echocardiogram to obtain images of the heart, and biopsies of muscle from the thigh and fat from the stomach. All participants will then receive atenolol once a day for 8 weeks. During Week 1, participants will receive a low dose of atenolol. They will then attend a study visit at the end of Week 1, and study researchers will examine how well participants are tolerating the medication. If the atenolol is well tolerated, the dose will be increased. Study researchers will call participants 1 week after any dosage changes to monitor for side effects. Blood collection will occur again at a study visit at Week 4. At Week 8, participants will then attend up to three study visits for repeat baseline testing. Participants will then be slowly tapered off of atenolol over a 1-week period.
BACKGROUND: Airflow obstruction is a hallmark of disease severity and prognosis in bronchiectasis. The relationship between lung microbiota, airway inflammation, and outcomes in bronchiectasis with fixed airflow obstruction (FAO) remains unclear. This study explores these interactions in bronchiectasis patients, with and without FAO, and compares them to those diagnosed with chronic obstructive pulmonary disease (COPD).
METHODS: This prospective observational study in Taiwan enrolled patients with either bronchiectasis or COPD. To analyze the lung microbiome and assess inflammatory markers, bronchoalveolar lavage (BAL) samples were collected for 16S rRNA gene sequencing. The study cohort comprised 181 patients: 86 with COPD, 46 with bronchiectasis, and 49 with bronchiectasis and FAO, as confirmed by spirometry.
RESULTS: Patients with bronchiectasis, with or without FAO, had similar microbiome profiles characterized by reduced alpha diversity and a predominance of Proteobacteria, distinctly different from COPD patients who exhibited more Firmicutes, greater diversity, and more commensal taxa. Furthermore, compared to COPD and bronchiectasis without FAO, bronchiectasis with FAO showed more severe disease and a higher risk of exacerbations. A significant correlation was found between the presence of Pseudomonas aeruginosa and increased airway neutrophilic inflammation such as Interleukin [IL]-1β, IL-8, and tumor necrosis factor-alpha [TNF]-α, as well as with higher bronchiectasis severity, which might contribute to an increased risk of exacerbations. Moreover, in bronchiectasis patients with FAO, the ROSE (Radiology, Obstruction, Symptoms, and Exposure) criteria were employed to classify individuals as either ROSE (+) or ROSE (-), based on smoking history. This classification highlighted differences in clinical features, inflammatory profiles, and slight microbiome variations between ROSE (-) and ROSE (+) patients, suggesting diverse endotypes within the bronchiectasis with FAO group.
CONCLUSION: Bronchiectasis patients with FAO may exhibit two distinct endotypes, as defined by ROSE criteria, characterized by greater disease severity and a lung microbiome more similar to bronchiectasis without FAO than to COPD. The significant correlation between Pseudomonas aeruginosa colonization and increased airway neutrophilic inflammation, as well as disease severity, underscores the clinical relevance of microbial patterns. This finding reinforces the potential role of these patterns in the progression and exacerbations of bronchiectasis with FAO.
The invention belongs to the field of traditional Chinese medicine preparation, and particularly relates to a black plaster and a preparation method thereof. The black plaster is prepared by refining medicinal materials, emu oil and yellow lead into paste, and spreading on a backing material. Because emu oil does not contain phosphorus, the emu oil can smoothly pass through skin barriers to reach the discomfort of human bodies, and has super-strong skin permeability, which is a characteristic that other oil does not have. And has the property of healing wounds due to the fatty acid composition, particularly high levels of gamma-linolenic acid and oleic acid. Linolenic acid is an unsaturated fatty acid, and can relieve joint pain; oleic acid is a monounsaturated fatty acid, and can be used for reducing inflammation of skin tissue and for adjuvant treatment. For the preparation of the black plaster, because the boiling point of the black plaster is lower than that of common sesame oil, tung oil or sesame oil and the like in the existing preparation, the medicine can be boiled at a relatively low temperature, the obtained medicine has more effective components, and the black plaster is not easy to lose efficacy due to high-temperature oxidation or other chemical actions.
1,267,477. Stripping dyes from hair. GILLETTE CO. 13 May, 1970 [21 May, 1969], No. 23204/70. Heading D1B. Compositions for removing dyes from hair comprise a two-phase liquid system including water and a liquid organic solvent for the dyes at least 1% by weight based on the weight of the liquids of an inorganic salt dissolved in the system and an alkaline material dissolved in the system to give a pH of 7.5 to 11.5 in the aqueous phase, the amount of each liquid phase being at least 1% by volume of the total composition. The solvent may be an alcohol, an ether or ether alcohol a phenol or ketone or ester, the salt being preferably a salt of an alkali or alkaline earth metal, alkaline materials being ammonia, sodium and potassium hydroxide, mono- and di-ethanolamine, acid dyes and acid premetallized dyes being removed by the compositions.