anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The safety and efficacy of Ovidrel® 250 µg and Ovidrel® 500 µg administered subcutaneously versus 10,000 USP Units of an approved urinary-derived hCG product administered intramuscularly were assessed in a randomized, open-label, multicenter study in infertile women undergoing in vitro fertilization and embryo transfer (Study 7927). The study was conducted in 20 U.S. centers.

The primary efficacy parameter in this single-cycle study was the number of oocytes retrieved. 297 patients entered the study, of whom 94 were randomized to receive Ovidrel® 250 µg. The number of oocytes retrieved was similar for the Ovidrel® and urinary-derived hCG (10,000 USP Units) treatment groups. The efficacy of Ovidrel® 250 µg and Ovidrel® 500 µg were both found to be clinically and statistically equivalent to that of the approved urinary-derived hCG product and to each other. The efficacy results for the patients who received Ovidrel® 250 µg are summarized in Table 3.

For the 33 patients who achieved a clinical pregnancy with Ovidrel® 250 µg, the outcomes of the pregnancies are presented in Table 4.

The safety and efficacy of Ovidrel® 250 µg administered subcutaneously versus 5,000 IU of an approved urinary-derived hCG product administered subcutaneously were assessed in a second, randomized, multicenter study in infertile women undergoing in vitro fertilization and embryo transfer (Study 7648). This double-blinded study was conducted in nine centers in Europe and Israel.

The primary efficacy parameter in this single-cycle study was the number of oocytes retrieved per patient. 205 patients entered the study, of whom 97 received Ovidrel® 250 µg. The efficacy of Ovidrel® 250 µg was found to be clinically and statistically equivalent to that of the approved urinary-derived hCG product. The results for the 97 patients who received Ovidrel® 250 µg are summarized in Table 5.

For the 32 patients who achieved a clinical pregnancy with Ovidrel® 250 µg, the outcomes of the pregnancies are presented in Table 6.
Oxytetracycline in a stablized condition is provided in the form of an elixir, injection, capsule and tablet.  The elixir contains 10 to 30 per cent ethanol, 1 to 4 per cent fruit acid (citric acid, ascorbic acid or tartaric acid), 20 to 50 per cent sucrose, 0.001 to 0.01 per cent saccharine, 1 to 15 per cent oxytetracycline hydrochloride and flavour, e.g. oils of peppermint and spearmint. Tablets contain the antibiotic mixed with dry starch e.g. potato or tapioca starch and magnesium stearate or calcium carbonate.  It is preferred to use as a binder a solution of polyvinylpyrrolidone in an organic solvent such as chloroform or acetone.  Optional additions are polyethylene oxide condensation products of sorbitan mono-oleate, polyethylene glycols, e.g. carbowax 6,000 sweeteners, e.g. sucrose and saccharin and flavours, e.g. oil of peppermint, methyl salicylate, oil of cassia and wild cherry.  Oily injections are prepared with injectable oils e.g. sesame, peanut or ethyl oleate, the oxytetracycline being of 200 mesh or less.  Aqueous injections are prepared by suspending oxytetracycline of 100 mesh or less in (a) water containing as dispersing agent a polyalkylene (e.g. ethylene or propylene) oxide derivative of a partial ester of a fatty acid having at least 10 carbon atoms per molecule (e.g. stearic or palmitic acid) with a polyhydric alcohol or anhydric thereof e.g. sorbitan, mannitol, ethylene glycol and propylene glycol; (b) aqueous solution of an amino acid, especially glycine or leucine, adjusted to pH 8.8 to 9.5 by the addition of an alkali metal base e.g. sodium hydroxide; and (e) aqueous solution of betaine hydrate and acetamide adjusted to pH 6.8 to 7.2 by the addition of triethanolamine.  Specification 684,417, [Group IV(b)], is referred to.
BACKGROUND: The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b and CD146. Endometrial regeneration is impaired in the presence of intrauterine adhesions, leading to infertility, recurrent pregnancy loss and placental abnormalities. Several types of somatic stem cells have been used to repair the damaged endometrium in animal models, reporting successful pregnancy. However, the ability of endometrial stem cells to repair the damaged endometrium remains unknown.
METHODS: Electrocoagulation was applied to the left uterine horn of NOD/SCID mice causing endometrial injury. Human eMSC or PBS was then injected into the left injured horn while the right normal horn served as controls. Mice were sacrificed at different timepoints (Day 3, 7 and 14) and the endometrial morphological changes as well as the degree of endometrial injury and repair were observed by histological staining. Gene expression of various inflammatory markers was assessed using qPCR. The functionality of the repaired endometrium was evaluated by fertility test.
RESULTS: Human eMSC successfully incorporated into the injured uterine horn, which displayed significant morphological restoration. Also, endometrium in the eMSC group showed better cell proliferation and glands formation than the PBS group. Although the number of blood vessels were similar between the two groups, gene expression of VEGF-α significantly increased in the eMSC group. Moreover, eMSC had a positive impact on the regeneration of both stromal and epithelial components of the mouse endometrium, indicated by significantly higher vimentin and CK19 protein expression. Reduced endometrial fibrosis and down-regulation of fibrosis markers were also observed in the eMSC group. The eMSC group had a significantly higher gene expression of anti-inflammatory factor Il-10 and lower mRNA level of pro-inflammatory factors Ifng and Il-2, indicating the role of eMSC in regulation of inflammatory reactions. The eMSC group showed higher implantation sites than the PBS group, suggesting better endometrial receptivity with the presence of newly emerged endometrial lining.
CONCLUSIONS: Our findings suggest eMSC improves regeneration of injured endometrium in mice.
BACKGROUND: There are few studies that assess the relationship between nutritional status and quality of life in individuals with Parkinson's disease, despite the well-established negative impact of sarcopenia and dynapenia on functional capacity and quality of life. These conditions impair protein-muscular status and are prevalent in individuals with Parkinson's disease. This study aimed to examine the relationship between nutritional status, including body composition, functional capacity, and diagnosis of sarcopenia and dynapenia, and quality-of-life perception in individuals with Parkinson's disease.
METHODS: This is a cross-sectional study conducted in two Parkinson's disease centers in the northeast of Brazil. The researchers assessed muscle strength, muscle mass, and physical performance to diagnose dynapenia, sarcopenia and functional capacity. Quality of life was estimated using the Parkinson's disease Quality of Life Questionnaire.
RESULTS: We found positive correlations between quality of life and variables such as severity and duration of the disease, as well as positive screening for sarcopenia (p<0.001). Negative correlations were observed between quality of life and muscle strength and functional capacity. The study also found that individuals with sarcopenia and dynapenia had significantly worse quality-of-life scores compared to those who did not have these nutritional outcomes (p <0.05; p <0.001).
CONCLUSIONS: The presence of sarcopenia, dynapenia, low gait speed, disease duration, and severity had an impact on higher scores in the Parkinson's Disease Quality of Life Questionnaire, indicating a worsening perception of quality of life.
The role of germline genetic testing in urologic oncology has expanded in recent years. However, implementation of genetic testing in community practices remains a challenge, often due to limited access to qualified genetics trained providers. In this study, we report outcomes of a universal germline screening program in a community urology practice. Between November 2021 and September 2022, all patients referred for urology clinic visits at Frederick Health (Frederick, MD, USA) were provided an online genetics screening questionnaire prior to the visit. Responses were compared against National Comprehensive Cancer Network (NCCN) criteria for germline testing. Those who met criteria were provided educational materials at the end of the questionnaire, and then counseled by a trained urologic oncologist (HC) in the clinic or referred to a genetic counselor prior to testing. Testing was performed with a 36-gene pan-cancer panel (CancerNext) or a 14-gene targeted prostate cancer panel (ProstateNext), with or without additional RNA analysis (RNAinsight) (Ambry Genetics, CA, USA). Demographic and clinical parameters, as well as genetic testing results, were retrospectively collected under IRB approval. In the study period, 765 patients were seen over 1370 clinic visits. Of these, 505 patients (66.0%) completed the screening questionnaire. The majority were completed via email (54.5%) with the remainder (45.5%) via text message. Of the patients who completed screening, 125/505 (24.7%) met NCCN criteria for germline testing. 58/125 patients (46.4%) who met criteria underwent germline testing, of whom 5/58 (8.6%) had distinct pathogenic mutations identified. These included actionable mutations in BRCA1, BRCA2, and CHEK2, as well as an additional pathogenic mutation in NBN. Variants of unknown significance were identified in 8/58 patients (13.8%) in 11 total genes. Challenges to implementation of this program included meeting institutional requirements for genetic testing consent, facilitating specimen collection in clinic, and integration of results into the electronic health record. Genetic risk assessment for high-risk individuals is feasible as part of a universal screening program in a community urology practice. Approximately 8% of tested patients were found to have pathogenic germline mutations, which is consistent with contemporary tertiary referral cohorts.
Base materials for powders and liniments are prepared by emulsion polymerizing monomers of plastics innocuous to the tissue of skin in the presence of emulsifiers to produce spherical particles of diameter less than 3m , dessicating the emulsion and disintegrating the product.  Alternatively the polymer emulsion may be treated with a water-soluble solvent, e.g. acetone or methyl ethyl ketone, and the agglomerated particle complexes of diameter 3 to 30m  filtered, washed, dried and the product disintegrated.  Suitable monomers are styrene, methyl methacrylate, isobutyl methacrylate, allyl methacrylate and ethylene glycol dimethacrylate.  Suitable emulsifiers are esters of higher fatty acids with polyhydric alcohols, e.g. sorbitol monostearate, sorbitol mono-oleate, sorbitol trioleate, polyoxyethylene sorbitol mono-oleate and polyoxyethylene trioleate, or quaternary ammonium compounds, e.g. stearyl dimethyl ethyl ammonium ethyl sulphate.  Suitable catalyst are ammonium persulphate and hydrogen peroxide.  Soluble perfumes and dyes may be added to the monomers.  Perfumes, e.g. bornyl acetate, dyes, ultramarine blue, titanium dioxide, zinc oxide, zinc stearate, glycerine and water may be incorpooated in the polymers.ALSO:Base materials for powders and linaments are prepared by emulsion polymerizing monomers of plastics innocuous to the tissue of skin in the presence of emulsifiers to produce spherical particles of diameter less than 3m , desiccating the emulsion and disintegrating the product.  Alternatively the polymer emulsion may be treated with a water-soluble solvent, e.g. acetone or methyl ethyl ketone, and the agglomerated particle complexes of diameter 3 to 30m  filtered, washed, dried and the product disintegrated.  Suitable monomers are styrene, methyl methacrylate iso-butyl methocrylate allyl methacrylate and ethyleneglycol dimethacrylate.  Suitable emulsifiers are esters of higher fatty acids with polyhydric alcohols, e.g. sorbitol monostearate, sorbitol monooleate, sorbitol trioleate, polyoxyethylene sorbitol monooleate and polyoxyethylene trioleate, or quaternary ammonium compounds, e.g. stearyl dimethyl ethyl ammonium ethyl sulphate.  Suitable catalysts are ammonium persulphate and hydrogen peroxide.  Perfumes, dyes, titanium dioxide, zinc oxide, zinc stearate, glycerine and water may be incorporated in the product.  Perfumes and dyes which are soluble in the monomers may be added to the monomers.  When using a perfume soluble in the plastic, e.g. bornyl acetate, a depot action is obtained which makes the perfume evaporate slowly.
The authors report their experience with twenty-one consecutive patients who presented with symptoms and imaging characteristics of a herniated lumbar disc; of whom, at the time of surgery had a vascular loop instead. The procedure was performed on 14 women and seven men with a mean age of 39 years. Clinical complaints included lumbar aching with one limb overt radiculopathy in all patients; with additional sphincter dysfunction in two cases. Symptoms had developed within a mean period of three months. In all patients, the disc was exposed through an L5-S1 (n = 10); L4-L5 (n = 5) and L3-L4 (n = 6) open minimal laminotomy. In 16 patients, rather than a herniated disc they had a lumbar epidural varix, while an arterio-venous fistula was found in the remaining five cases. In all cases, the vascular disorder was resected and its subjacent disc was left intact. One patient had a postoperative blood transfusion. While the radiculopathy dysfunction improved in all patients, four patients reported lasting lumbar pain following surgery. The postoperative imaging confirmed the resolution of the vascular anomaly and an intact disc. The mean length of the follow-up period was 47 months. Either epidural varix or arterio-venous fistula in the lumbar area may mimic a herniated disc on imaging studies. With the usual technique they can be operated safely. Resection of the anomaly can be sufficient for alleviating radiculopathy symptoms.
OBJECTIVES: The association between obesity and gastroesophageal reflux disease (GERD) is well-established in adults; however, data in pediatric population is scarce. Our study aimed to assess the association between GERD and health-related quality of life (HRQoL) in overweight children.
METHODS: From April to August of 2020, we included children aged 7-18 years who attended the Endocrinological Outpatient Clinic at the Paediatric Institute, University of Debrecen, Hungary. The participants completed two questionnaires: the Pediatric Gastroesophageal Reflux Disease Symptom Questionnaire (PGSQ) and the HRQoL questionnaire (PedsQL). Based on the criteria of the World Health Organization (WHO), the patients were categorized into two groups: an overweight or obese group and a group with normal weight.
RESULTS: A total of 107 children (51 % female, mean age 13.2 years, 46 % overweight or obese) completed the questionnaires. The median PGSQ score was similar in both groups (4.0 (IQR: 1.0-7.8) vs. 3.0 (IQR: 1.0-7.0), p=0.6). However, the total PedsQL score was significantly lower in the children with overweight or obesity compared to those with normal weight (80.1 (71.1-91.0) vs. 88.0 (76.1-94.6), p=0.031). The PedsQL score was lower among overweight patients with GERD symptoms than that of normal-weight patients without GERD symptoms.
CONCLUSIONS: Our findings highlight the importance of raising awareness about GERD to enhance the HRQoL and prevent long-term complications in obese children.
For the QL block, the transducer will be placed transversely over the lumbar spine at the level of the iliac crest. Then, the anesthesiologist will scan laterally to identify the ipsilateral L3 transverse process, psoas muscle, and quadratus lumborum muscle to identify the "Shamrock Sign" (7). Following aseptic preparation of the injection site and the ultrasound probe, a 22-gauge, 10mm block needle will be introduced parallel to the ultrasound guided beam (in-plane technique) until its tip reaches the plane between the quadratus lumborum muscle and psoas muscle. After negative aspiration, 20 ml of a mixture containing 10ml 0.25% bupivacaine and 10ml 1.3% liposomal bupivacaine will be injected in 5 ml increments to separate the fascial plane between the two muscles. The investigators will observe local anesthetic spread under real-time imaging. The block will then be performed in the same manner on the opposite site.
Among the patients in the control group with peripheral vestibular disorders, 12 sessions were given routinely, 3 days a week, for 4 weeks. They were asked to perform gaze stabilization exercises for 1 min. Gaze stabilization exercises consist of head-fixed right-left eye movements, head-fixed up-down eye movements, eye fixed right-left head movements, and eye fixed up-down head movements.
INTRODUCTION: Sleeve gastrectomy (SG), results in improvement in hypertension. We have previously published that rodent SG improves hypertension independent of weight loss associated with unique shifts in the gut microbiome. We tested if the gut microbiome directly improves blood pressure by performing fecal material transfer (FMT) from post-SG rats to surgery-naïve animals.
METHODS: We performed SG or Sham surgery in male, Zucker rats (n = 6-7) with obesity. Stool was collected postop from surgical donors for treatment of recipient rats. Three nonsurgical groups received daily, oral consumption of SG stool, sham stool, or vehicle alone (Nutella) for 10 wk (n = 7-8). FMT treatment was assessed for effects on body weight, food intake, oral glucose tolerance, and blood pressure. Genomic deoxyribonucleic acid of stool from donor and recipient groups were sequenced by 16S ribosomal ribonucleic acid and analyzed for diversity, abundance, and importance.
RESULTS: Ten weeks of SG-FMT treatment significantly lowered systolic blood pressures in surgery-naïve, recipient rats compared to vehicle treatment alone (126.8 ± 13.3 mmHg versus 151.8 ± 12.2 mmHg, P = 0.001). SG-FMT treatment also significantly altered beta diversity metrics compared to Sham-FMT and vehicle treatment. In random forest analysis, amplicon sequence variant level significantly predicted FMT group, P = 0.01.
CONCLUSIONS: We have found a direct link between gut microbial changes after SG and regulation of blood pressure. Future mechanistic studies are required to learn what specific gut microbial changes are required to induce improvements in obesity-associated hypertension and translation to clinical, metabolic surgery.
The specific aims of the study are:1) to test the DART program's effectiveness on a) overall antibiotic prescribing rates for all pediatric ARTIs and b) first-line antibiotic prescribing rates for bacterial ARTIs (acute otitis media, Group A Streptococcal pharyngitis, and sinusitis), 2) to test the DART program's effectiveness in changing providers' communication practices during ARTI visits, 3) to determine visit-specific satisfaction levels for parents of children seen by study providers and assess how satisfaction changes as a function of exposure to the DART program, and 4) to assess the cost of implementing the DART program and its impact on health care expenditures.

To accomplish these aims, we propose a quasi-experimental study utilizing a stepped wedge design. In collaboration with two practice-based research networks: the electronic Pediatric Research in Office Settings (ePROS) network and the NorthShore Pediatric network, we will recruit 20 practices to participate. Over a 20 month period, the intervention will be sequentially deployed to 4 groups of practices (5 practices/group). Each practice will function as part of the control group until they receive the intervention. The DART program's effectiveness will be assessed by examining provider antibiotic prescribing rates for ARTIs (both overall and first-line), communication practices, and parent satisfaction both pre- and post-intervention exposure using survey and electronic health record data. If the DART program is effective for both reducing ARTI antibiotic prescribing to levels consistent with bacterial prevalence rates and increasing use of first-line antibiotics for bacterial ARTIs, we will have an innovative, highly disseminable QI intervention program to further address this critical public health problem.
For patients with symptomatic gallstones, surgery offers the advantage of immediate and permanent stone removal, but carries a high risk in some patients. About 5% of cholecystectomized patients have residual symptoms or retained common duct stones. The spectrum of surgical risk varies as a function of age and the presence of disease other than cholelithiasis.

* In good health or with moderate systemic disease.  
** With severe or extreme systemic disease.  
*** Includes both elective and emergency surgery.

Women in good health or who have only moderate systemic disease and are under 49 years of age have the lowest surgical mortality rate (0.054); men in all categories have a surgical mortality rate twice that of women. Common duct exploration quadruples the rates in all categories. The rates rise with each decade of life and increase tenfold or more in all categories with severe or extreme systemic disease.
PURPOSE:To easily prepare an almost neutral aq. calcium soln. by electrolyzing a raw water into acidic ionized water and alkaline ionized water, bringing a powdery or granular calcium component into contact with the obtained acidic ionized water to dissolve the component. CONSTITUTION:A weathered coral (or a fossil shell) as the calcium component is crushed to about 1-3mm diameter and formed into a coral granular body which is packed in a cylinder 5. The city water kept at pH 7.1 and having 23.0mg/l calcium hardness is supplied into an electrolytic cell 2 through a water feed pipe 1 and subjected to electrolysis to form an acidic ionized water at pH 3.5 and an alkaline ionized water at pH10. The obtained acidic ionized water is introduced into the calcium-contg. cylinder 5 through a duct 3, brought into contact with the coral granular body and fluidized, and an almost neutral aq. calcium hydroxide soln. kept at pH7.1, having 98.0mg/l calcium hardness and suitable for drinking water, rust inhibiting water and sterilizing water is obtained from a water suction port 5A.
Bipolar disorder is a common lifelong psychiatric disorder characterized by recurrent mood swings with manic or hypomanic episodes alternated with depressive episodes of longer duration. Patients spend more time in depression than in (hypo)mania over their life time. The main goals for the treatment of bipolar disorder are resolution of symptoms, return to premorbid level of social functioning and prevention of future episodes.

Although there are many treatments for bipolar disorder, few are approved, and they have limitations in their use due to safety and tolerability issues. Recommendations exist to use mood stabilisers, antipsychotics or a combination thereof with or without antidepressants and the polypharmacy employed in many cases is a reason for concern. There is a major medical need for more effective treatments in monotherapy with a reduced potential for adverse effects. This study evaluates the efficacy and safety of the new drug, Lu AA39959, in treatment of depression in patients with bipolar disorder.
Only patients who were transferred by emergency medical service from the accident site with a systolic blood pressure ≥ 90 mm Hg at the ER were included in this study. The enrolled trauma patients divided into 2 groups, those who had received blood transfusion ≥ 10 U (massive transfusion) and those who had not (non-massive transfusion).
Overweight or obese is defined as BMI \> 25 kg/m2. Subjects will receive the institutional standard intravenous immune globulin treatment.