anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Virtual chromoendoscopy systems enhances specific characteristics of the lining of the large bowel such as surface patterns and mucosal vasculature. This theoretically increases the detection of pre-cancerous tissue compared to high definition white light endoscopy alone. Narrow-band imaging or NBI (Olympus, Tokyo, Japan), Blue Laser (Fujinon, Tokyo, Japan) and OE scan (Pentax, Tokyo, Japan) use optical light filters to select particular narrow spectrums of red, green and blue light with a relative decrease in the proportion of red light. The Fujinon Intelligent Chromo-Endoscopy (FICE) system uses post hoc computer algorithms, applying different filters to the stored endoscopic images and enabling a theoretically endless number of combinations of filters that can be used. The Pentax I-SCAN system also allows post hoc modification of the images. It provides the ability to enhance the mucosal surface to better highlight mucosal changes.

These new imaging techniques have a theoretical advantage, which is extendedly used for sales purposes but so far has not been proven in the surveillance for precancerous or early cancer of the large bowel in patients with longstanding colitis.
1. The method of producing an amorphous form of 1-acetoxyethyl cefuroxime ester, characterised in that a solution with the concentration under 15 percent m/v is prepared out of raw amorphous 1-acetoxyethyl cefuroxime ester or a mixture of raw amorphous and crystalline ester, containing under 8 percent of impurities. The solution is prepared in an organic solvent, such as an aliphatic ketone, aliphatic alcohol, aliphatic nitril, aliphatic ester, halogen derivatives of aliphatic hydrocarbons or mixtures of the listed organic solvents, or in mixtures of the mentioned solvents with water. The prepared solution is purified with activated charcoal. Then, resolvents - such as polyhydroxyl alcohols, esters of polyhydroxyl alcohols, organic acids, salts of organic acids, spans, polysorbates, polyethylene glycols or lecitine - are added in the presence of a polar solvent. 0.05 to 2.0 percent of resolvents are added. The final amorphous form of the ester is educed by spray-drying or vacuum evaporation.
The invention discloses water-soluble dipropofol and a preparation method thereof. The water-soluble dipropofol has a certain general formula structure. The preparation method comprises the following steps of: reacting propofol, dihalogen acid and derivative thereof to generate diester under the alkali condition, and reacting the diester, phosphoric acid, thiophosphoric acid and derivatives thereof to obtain the water-soluble dipropofol. By introducing two-molecule propofol, the water-soluble dipropofol reduces the intake of the phosphorus, and has quick response; and the preparation method has the advantages of easily obtained raw materials, mild reaction conditions, convenient operation and easy industrialized production. The prepared injection has good water solubility and high stability, and enlarges the using crowds of the medicament. The water-soluble dipropofol can overcome the defects that the propofol emulsion is instable on thermodynamics and dynamics, easy to pollute and propagate microbes and inconvenient to store and use, can reduce or remove injection pain, reduces the intake of the phosphorus, and has quick response.
PURPOSE:To provide an agent for improving the energy metabolism, capable of remarkably mitigating the adynamia caused by renal insufficiency, diabetes, etc., by using one or more compounds selected from glycocyamine which is a metabolic precursor of creatine phosphate, its derivative and its acid addition salt. CONSTITUTION:The titled improving agent is prepared by using one or more compounds selected from glycocyamine, a glycocyamine derivative which can be converted to glycocyamine in the living body (e.g. glycocyamine ethyl ester) and its acid addition salt (e.g. glycocyamine hydrochloride). It has been found newly that the glycocyamine administered externally to the body exhibits remarkable effect to improve the energy metabolism. That is, the energy metabolism of the skeletal muscle lowered by renal diseases, diabetes, etc. can be improved and the nutrition state can be restored. It is preferably administered in the form of tablet, capsule, injection, etc. Dose: preferably 500-1,500mg daily for oral administration.
Patients undergo a video-based intervention prior to undergoing LCS. Patients watch a 5-minute video that focuses on preparing patients for LCS by providing information on the following: program team and contact information; reason to be screened; screening eligibility; how screening is performed; what to expect on the day of screening; what to expect after screening; what to expect if result is positive; what to expect if result is negative; and risks of screening. Patients also receive an educational handbook. Patients with positive scans (a Lung-RADS 3 or 4) receive additional brochure and nursing support within 1 week after notification of scan results.
The invention discloses a cherry, blueberry and honey wine. The cherry, blueberry and honey wine is made of, by weight, 100-150 parts of fresh blueberries, 10-20 parts of cherries, 7-8 of honey, 6-7 parts of pollen, 10-11 parts of hawthorn fruits, 2-3 parts of mango seeds, 2.3-2.4 parts of sealwort, 1.3-2 parts of momordica grosvenori, purified liquor, pectinase, 4-5% sugar liquor and an appropriate amount of dry yeast. The obtained health care blueberry wine has the advantages of the purified liquor which is clear, transparent and has the strong aftertaste. The blueberry fragrance and wine fragrance are mixed, so that the taste of the wine is enhanced, mellow and pleasant. By adding leonurus, radix angelicae, the momordica grosvenori and the like, the cherry, blueberry and honey wine has the medical health care functions of nourishing kidney and lung, invigorating spleen and replenishing qi, delaying senescence, improving appetite and promoting digestion, nourishing yin and reducing phlegm, and clearing heat and moistening lung. The cherry, blueberry and honey wine has the wide development space and market prospect.
No-treatment control group. Measurements taken at baseline, 12 weeks and 1 year. People in the control condition can elect to take the intervention after 1 year.
OBJECTIVE: The autonomic nervous system (ANS) plays an important role in maintaining physiological regulation. It regulates the body's response to many variable situations. Orthostatic intolerance (OI) is one of the most important signs of autonomic dysfunction. Autonomic dysfunction is known to cause premature ejaculation (PE) by disturbing the balance in erection and ejaculation cycles. Considering that OI may develop due to autonomic dysfunction in patients with PE, we hypothesized that OI symptoms would increase in these patients. The aim of our study was to investigate the relationship between orthostatic intolerance and PE.
PATIENTS AND METHODS: This case-control study included a total of 39 patients with PE and 47 volunteers without PE. All subjects were assessed using the self-reported Orthostatic Grading Scale (OGS). In addition, the validated five-item Turkish version of the Premature Ejaculation Diagnostic Tool (PEDT) was used to evaluate PE. The PE group included patients with a PEDT score ≥ 11.
RESULTS: The mean ages of the PE and control groups were 38.2 ± 7.8 and 40.5 ± 9.1 years, respectively (p = 0.137). The mean PEDT scores of the PE and control groups were 13.9 ± 3.6 and 6.6 ± 2.9, respectively (p < 0.0001), and their mean OGS scores were 5.6 ± 2.4 and 1.6 ± 1.3, respectively (p < 0.0001). A statistically significant correlation was found between the PEDT and OGS scores (r: 0.686, p < 0.0001).
CONCLUSIONS: The orthostatic intolerance symptoms of patients with PE were higher than those of the control group. There was a correlation between the severity of PE and the severity of orthostatic intolerance. This is the first study in the literature to reveal a relationship between orthostatic intolerance and PE.
This study was conceived to explore the role and the mechanism of Loureirin B (LB) in hepatic IRI. The viability of LB-treated AML-12 cells was assessed using CCK-8 assay and inflammatory cytokines were detected using ELISA. The activities of ROS and oxidative stress markers MDA, SOD, and GSH-Px were detected using DCFH-DA and corresponding assay kits. The cell apoptosis and caspase3 activity were estimated with flow cytometry and caspase3 assay kits. The expressions of arachidonate 5-lipoxygenase (ALOX5) and apoptosis- and mitochondrial dynamics-related proteins were detected using western blot. The interaction between LB and ALOX5 was analyzed with molecular docking. The transfection efficacy of oe-ALOX5 was examined with RT-qPCR and western blot. Mitochondrial membrane potential was detected with JC-1 staining and immunofluorescence (IF) assay was employed to estimate mitochondrial fusion and fission. The present work found that LB revived the viability, inhibited inflammatory response, suppressed oxidative stress, repressed the apoptosis, and maintained mitochondrial homeostasis in H/R-induced AML-12 cells, which were all reversed by ALOX5 overexpression. Collectively, LB regulated mitochondrial homeostasis by downregulating ALOX5, thereby improving hepatic IRI.
The mortality rate among cancer patients is primarily attributed to tumor metastasis. The evaluation of metastasis potential provides a powerful framework for personalized therapies. However, little work has so far been undertaken to precisely model tumor metastasis in vitro, hindering the development of preventive and therapeutic interventions. In this work, a tumor-metastasis-mimicked Transwell-integrated organoids-on-a-chip platform (TOP) for precisely evaluating tumor metastatic potential is developed. Unlike the conventional Transwell device for detecting cell migration, the engineered device facilitates the assessment of metastasis in patient-derived organoids (PDO). Furthermore, a novel Transwell chamber with a hexagon-shaped structure is developed to mimic the migration of tumor cells into surrounding tissues, allowing for the evaluation of tumor metastasis in a horizontal direction. As a proof-of-concept demonstration, tumor organoids and metastatic clusters are further evaluated at the protein, genetic, and phenotypic levels. In addition, preliminary drug screening is undertaken to highlight the potential for using the device to combat cancers. In summary, the tumor-metastasis-mimicked TOP offers unique capabilities for evaluating the metastasis potential of tumor organoids and contributes to the development of personalized cancer therapies.
Subjects age 21 to 80 year old, who have elected to undergo a plastic surgery will be enrolled. Subjects will be from Chinese, Malay, Indian or Caucasian ancestry. Subjects will be female or male with a hyper-pigmented spots.
Sepsis-induced acute lung injury (SALI) poses a significant threat with high incidence and mortality rates. Ginsenoside Rg1 (GRg1), derived from Ginseng in traditional Chinese medicine, has been found to reduce inflammation and protect lung epithelial cells against tissue damage. However, the specific roles and mechanisms by which GRg1 mitigates SALI have yet to be fully elucidated. In this context, we employed a relevant SALI mouse model, alongside network pharmacology, molecular docking, and molecular dynamics simulation to pinpoint GRg1's action targets, complemented by in vitro assays to explore the underlying mechanisms. Our research shows that GRg1 alleviates CLP-induced SALI, decreasing lung tissue damage and levels of serum proinflammatory factor IL-6, TNF-α, and IL-1β, also enhancing the survival rate of CLP mice. A total of 116 common targets between GRg1 and ALI, with specific core targets including AKT1, VEGFA, SRC, IGF1, ESR1, STAT3, and ALB. Further in vitro experiments assessed GRg1's intervention effects on MLE-12 cells exposed to LPS, with qRT-PCR analysis and molecular dynamics simulations confirming AKT1 as the key target with the favorable binding activity for GRg1. Western blot results indicated that GRg1 increased the Bcl-2/Bax protein expression ratio to reduce apoptosis and decreased the high expression of cleaved caspase-3 in LPS-induced MLE-12 cells. More results showed significant increases in the phosphorylation of PI3K and AKT1. Flow cytometric analysis using PI and Annexin-V assays further verified that GRg1 decreased the apoptosis rate in LPS-stimulated MLE-12 cells (from 14.85 to 6.54%, p < 0.05). The employment of the AKT1 inhibitor LY294002 confirmed these trends, indicating that AKT1's inhibition negates GRg1's protective effects on LPS-stimulated MLE-12 cells. In conclusion, our research highlights GRg1's potential as an effective adjunct therapy for SALI, primarily by inhibiting apoptosis in alveolar epithelial cells and reducing pro-inflammatory cytokine secretion, thus significantly enhancing the survival rates of CLP mice. These beneficial effects are mediated through targeting AKT1 and activating the PI3K-AKT pathway.
PURPOSE:To collect an antitumor substance from TETSUJUYOU, Xanthii fructus, TAKUSHITSU and Dianthi herba of crude drug. CONSTITUTION:TETSUJUYOU, Xanthii fructus and TAKUSHITSU are extracted with an acidic lower alcohol and the solvent is distilled away to give an extracted essence. The essence is dissolved in a dilute aqueous solution of alkali, shaken with n-butanol, the butanol layer is collected and butanol is distilled away to give an antitumor substance. An amount of acid added to an acidic lower alcohol solution is varied depending upon crude drugs and is generally <=1%. Extraction is carried out under heating or at room temperature and the alkali concentration of the aqueous solution of alkali is <=1%. To extract an antitumor substance from Dianthi herba, Dianthi herba is firstly treated with a lower alcohol, the alcohol extracted solution is extracted with hot water and water is distilled away from the hot water extracted solution under reduced pressure to give an extract.
The present invention relates to a traditional Chinese medicine composite, tablet treating hepatitis B residual jaundice and preparation method thereof, which belongs to the technical filed of traditional Chinese medicine preparation and preparation method. The traditional Chinese medicine composite comprises golden thread, natural indigo, alum and turmeric root-tuber. The weight ratio of the components is that the golden thread to the natural indigo to the alum to the turmeric root-tuber equals 2 to 2 to 1 to 1. The traditional Chinese medicine tablets comprise active ingredients and pharmaceutically acceptable carriers. Wherein, the active ingredients are the traditional Chinese medicine composite. The tables are prepared by smashing raw material powder, passing the sieve of 20 to 400 meshes, being mixed with the pharmaceutically acceptable carriers evenly, passing the sieve of 18 meshes and being granulated and tableted. The invention has good treatment effect for chronic hepatitis B residual jaundice and the price is low.
PURPOSE: Liver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a). In rodents, LEAP-2 blunts ghrelin-induced feeding and its plasma levels are modulated in response to nutritional status, being decreased upon fasting and increased in high-fat diet (HFD) fed mice. Clinical data support the regulation of circulating LEAP-2 by nutrient availability in humans. In this work, our primary objective was to examine the chronic effects of ghrelin and LEAP-2 administration on food intake, adiposity, and energy expenditure in young mice subjected to standard and HFD at both room temperature and at thermoneutrality. Furthermore, we aimed to assess the impact of these two hormones on aging mice.
RESULTS: Our results indicate that LEAP-2 produces a significant decrease of body weight and adiposity, an increase in energy expenditure, and activation of the thermogenic program in white and brown adipose tissue depots. However, this effect is not maintained under HFD or under thermoneutral conditions and is only partially observed in aging mice.
CONCLUSION: In summary our studies describe the central effects of LEAP-2 within distinct experimental contexts, and contribute to the comprehension of LEAP-2's role in energy metabolism.
A method for improving cardiovascular health in a human subject includes administering a composition to the human subject identified as being at risk for cardiovascular disease. The composition includes macular xanthophylls. In certain instances, the composition may be provided as a single consumable including lutein, zeaxanthin, and meso-zeaxanthin. The single consumable may include 10 milligrams of lutein, 2 milligrams of zeaxanthin, and 10 milligrams of meso-zeaxanthin. In other instances, the composition may be provided as two or more consumable. The two or more consumable collectively including lutein, zeaxanthin, and meso-zeaxanthin.
Provided is a vagina embolism device of cow synchronization of estrus. The vagina embolism device of cow synchronization of estrus is in a Y shape and is composed of a plastic skeleton, silicon rubber medicine slow release caps and a plastic digging rope. Two cylinder slice layer shape silicon rubber medicine slow release caps are sleeved on two upper forks of the Y-shaped plastic skeleton. The cylinder slice layer shape silicon rubber medicine slow release caps are prepared by mixing vinyl silicon rubber, silicon rubber cross-linking agent, flugestone powder and stearic acid slow-release formulation according to a ratio and through ejection molding. When the vagina embolism device of cow synchronization of estrus is used, all parts are assembled and placed in the vagina of a cowinestrus and taken out in 10 to 15 days. Flugestone hormone is utilized to inhibit natural estrus action of the cow, when the action is relieved, the cow group can rut synchronously, and a goal of controlling animal estrus through manual work can be achieved.
Coronary artery disease (CAD) is still one of the major contributors to global mortality. CTO is a special lesion type of CAD, defined as complete occlusion of at least one major epicardial coronary artery more than 3 months. Compared to non-CTO patients, those with CTO have worse prognosis. The prognosis of CTO patients is related to many factors including the baseline characteristics, modality of treatment and the degree of coronary collateral formation. Figuring out the factors which can indicate the outcomes of CTO is essential to clinical decision making. In this single center, observational study, we collect patient's clinical characteristics and blood samples to investigate potential factors associated with the development of coronary collateral formation and outcomes in patents with stable coronary artery disease.
The Intervention group will adopt the mode of online and offline blended learning based on the Chaoxing mobile application (Chaoxing app). The researchers will create surgical nursing practice courses on the Chaoxing app, and the experimental group will be subjected to 2 months of online and offline blended teaching intervention using the Chaoxing app.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of cirrhosis but is underrecognized in primary care. Cirrhosis management requires complex monitoring, and the quality of care (QoC) for NAFLD cirrhosis patients in primary care may be inadequate.
METHODS: In this retrospective-prospective cohort study of primary care patients with diabetes mellitus, we identified patients with NAFLD cirrhosis by 1) evidence of cirrhosis from abdominal imaging identified by natural language processing, or 2) existence of International Classification of Diseases code for cirrhosis. A finding of either was followed by manual chart review for confirmation of both cirrhosis and NAFLD. We then determined if cirrhosis care measures were up-to-date, including hepatitis A and B vaccination, Model for End-Stage Liver Disease score components, esophagogastroduodenoscopy, and hepatocellular carcinoma screening. We created a composite score quantifying overall QoC (scale 0-8), with high QoC defined as ≥6 points.
RESULTS: Among 3,028 primary care patients with diabetes mellitus, we identified 51 (1.7%) with NAFLD cirrhosis. Although 78% had ≥3 average primary care visits/year, only 24% completed hepatocellular carcinoma screening at least annually in at least 75% of years since diagnosis. The average QoC composite score was 4.9 (SD 2.4), and less than one-third had high QoC.
CONCLUSIONS: NAFLD cirrhosis is prevalent but underdiagnosed in primary care, and receipt of comprehensive QoC was suboptimal. Given the rising incidence of NAFLD cirrhosis, primary care providers need improved awareness and mechanisms to ensure high QoC for this population.
A non-naturally occurring polynucleotide encoding a miRNA that inhibits the expression of an immune checkpoint protein. The polynucleotide may further encode a chimeric receptor, a cytokine, and/or a cell tag. A vector comprising the aforementioned polynucleotide. A modified immune effector cell comprising the aforementioned polynucleotide. Compositions and kits comprising the aforementioned polynucleotide and/or cell. A method for treating a subject suffering from a disease or disorder, comprising administering the aforementioned cell to a subject in need thereof. The use of the aforementioned cell in the manufacture of a medicament for the treatment of a disease or disorder. A method for the detection of a disease or disorder associated with the overexpression of an antigen in a subject. A method for the treatment of a disease or disorder comprising the serial administration of polynucleotides encoding a chimeric antigen receptor or a cell comprising the same.
The Comarca Ngäbe-Buglé (CNB), home to >200,000 Indigenous people, is one of the poorest regions in Panama. We describe transactional sex (TS) behaviours, normative beliefs and factors associated with TS among Indigenous adolescents(14-19years) in the CNB. We conducted a mixed-methods study in the CNB between January and November 2018, which included a qualitative study with participant observation and semi-structured interviews that focused on descriptive norms related to TS; and a cross-sectional study among public-school-going adolescents using self-administered questionnaire to report sexual behaviour and injunctive norms related to TS. Participants in the epidemiological study were also asked to submit samples for HIV, syphilis, chlamydia, and gonorrhoea testing. Qualitative thematic analysis was used to organise and analyse field notes and semi-structured interviews. Quantitative analysis included four models: TS experience and acceptance of a TS offer and the associations of these outcome variables with demographic and behavioural variables and HIV/STI infections. In the qualitative study among 20 adolescents, we found that people offering TS were reported to be from within and outside of the community, and included older men and women, and disturbingly, teachers. Participants reported feeling individual and collective agency in the decision to engage in TS and described little social sanctions for participation. In the quantitative study among 700 adolescents(309 girls[45.1%],379 boys[54.9%]), we found that girls(18.8%;58/309) and boys(15.5%;58/379) reported similar levels of having been offered TS, and of acceptance among those offered(girls 81.4% [35/43]; boys 77.8% [35/45]). TS was found to be associated with the reported forced sex and HIV/syphilis seropositivity. Due to widespread acceptance and feelings of agency, interventions would not be effective if they focused on eliminating the transactional component of sexual encounters. Instead, interventions should focus on individual and household economic stability, increasing violence reporting, bringing perpetrators to justice, and adopting condom use during all sexual encounters.