anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients with new diagnosis of 1) microscopic polyangiitis, polyarteritis nodosa or eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome) and 2) without any factor of poor prognosis according to the French five factors score (FFS - including creatininemia \>140µmol/l, proteinuria \>1 g/24 h, specific gastro-intestinal involvement, specific cardiomyopathy, and CNS involvement) can be included at diagnosis or within the first 15 days following initiation of corticosteroids. Treatment is randomly assigned, centrally, and received in a double-blinded fashion. It consists in a combination of azathioprine (2 mg/kg/day) and corticosteroids (starting at 1 mg/kg/day for 3 weeks then progressively tapered over a mean of 50 weeks, varying according to patient's weight) or, for the control group, the same corticosteroid therapy plus placebo. Duration of azathioprine or placebo is 12 months, and patients are followed for 12 additional months, yielding in a total duration of the protocol of 24 months after entry for each patient. End point is the number of patients who achieve sustained remission and who do not suffer a relapse during the 24 months of the study protocol. Based on the results of the early CHUSPAN trial for similar patients treated with corticosteroids alone, the cumulative rate of failures and relapses can be estimated at 40% at 24 months. The primary hypothesis of the CHUSPAN 2 is a reduction by at least 25% for the rate of this combined parameter of remission-treatment failure and relapse at 24 months. Based on this hypothesis, using a bilateral test, with a significance level of 5%, a beta level of 80% and an estimated 5% of lost-of-follow-up, 104 patients must be included. Secondary end points include the initial remission rate (independently of subsequent relapses), rate of adverse events and their severity according to the WHO toxicity grading system, number of deaths, number of patients who could not be weaned of corticosteroids, area under the curve for corticosteroids, and different scales, such as BVAS (activity of the disease), VDI (damage), HAQ, SF36, ADL and the evaluation of the need for health care facilities.
<P>PROBLEM TO BE SOLVED: To provide a substance having a health effect and originated harsh taste-removed Aesculus turbinate fruits, and to provide its utilization technique.  <P>SOLUTION: It has been found that new substances originated from escin contained in Aesculus turbinate fruits treated with a wood ash liquid and capable of being used as a food have a blood glucose level rise-inhibiting action. The new substances have been identified as deacetylated substances of escins Ia, IIa, Ib and IIb. The biological activities of the deacetylated substances of the escins have been measured by subjecting a fraction containing the deacetylated escins to a mouse oral glucose tolerance test. A significant blood glucose level rise-inhibiting action has been found in a once oral administration of saponins into a mouse at a rate of 300 mg/kg. The blood glucose level rise inhibitor can be used by mixing the inhibitor with a food or the like.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
This study evaluates how food addiction is related to chronotype, social jetlag, and psychological pain. Of the participants (n = 1,035 university students), 16.6% had a morning chronotype, 25.1% had an evening chronotype, and 25.1% were clinically addicted to eating. The mean sleep durations for participants were 7.41 ± 2.18 h and 8.95 ± 3.0 h on weekdays and weekends, respectively. The mean misalignment time for social jetlag was 1.45 ± 1.5 h. Food addiction, psychological pain, and social jetlag levels were high among participants with the evening chronotype. The risk factors for food addiction included being female, having an evening chronotype, and having high body mass index levels and psychological pain. The total indirect effect of psychological pain and social jetlag on the relationship between chronotype and food addiction was 20.6%. However, the social jetlag effect is relatively minor compared to psychological pain. The significant conclusions of this study are as follows. Clinical food addiction is prevalent among students, and a strong direct correlation between chronotype and food addiction was observed. The study emphasizes the importance of being aware of chronotype and mental status in establishing a healthy diet and lifestyle.
PURPOSE: To obtain a hair cosmetic having excellent dandruff preventing effect by including vitamin A and an antibacterial agent. CONSTITUTION: This hair cosmetic contains vitamin A (e.g. retinol) in an amount of 0.001-0.5wt.% and an antibacterial agent (e.g. piroctone olamine) in an amount of 0.0001-5wt.%. Further, the objective cosmetic is suitably mixed with an additive usually used in a hair cosmetic and may be formed to hair tonic, hair liquid, latex for scalp, hair cream, hair shampoo, hair rinse or hair spray, etc. The objective cosmetic is useful for cure of keratonosis because vitamin A has an important activity to normal differentiation and preservation of skin, and also has a dandruff preventing effect because of high cuticle tissue-flexible action. Use of vitamin A in combination with an antibacterial agent exhibits further excellent dandruff preventing effect than a sole use of the antibacterial agent.
This invention relates to haemostatic agacutin extracted from venin of Agkisdroton acututs. The haemostatic agacutin (31 kD) is extracted from venin of Agkisdroton acututs, and comprises two peptide chains (16 kD and 15 kD). The optimum temperature of the haemostatic agacutin is 35 deg.C, the optimum pH value is 7.5, and the isoelectric point is 5.39. The HPLC chromatogram of the haemostatic agacutin has a single peak. The N-terminal amino acid sequence of A subunit DCSSGWSSYEEHQYY, and B unit DSSGWSSYEGHEYYV, are shown in this invention. It is proven by acid hydrolysis that haemostatic agacutin comprises 18 or 20 kinds of amino acids. The haemostatic agacutin can coagulate fibrinogen, and the plasma coagulation time is 60 plus and minus 5 s. The haemostatic agacutin has such advantages as short whole blood clotting time and no thrombosis. The haemostatic agacutin can be used to prevent operation bleeding, treat traumatic bleeding and diagnose clotting time in clinic. The haemostatic agacutin can be also used in systemic and local hemostasis.
Covariate analysis in population pharmacokinetics is key for adjusting doses for patients. The main objective of this work was to compare the adequacy of various modeling approaches on covariate clinical relevance decision-making. The full model, stepwise covariate model (SCM) and SCM+ PsN algorithms were compared in a clinical trial simulation of a 383-patient population pharmacokinetic study mixing rich and sparse designs. A one-compartment model with first-order absorption was used. A base model including a body weight effect on CL/F and V/F and a covariate model including 4 additional covariates-parameters relationships were simulated. As for forest plots, ratios between covariates at a specific value and that of a typical individual were calculated with their 90% confidence interval (CI90) using standard errors. Covariates on CL, V and KA were considered relevant if their CI90 fell completely outside the reference area [0.8-1.2]. All approaches provided unbiased covariate ratio estimates. For covariates with a simulated effect, the 3 approaches correctly identify their clinical relevance. However, significant covariates were missed in up to 15% of cases with SCM/SCM+. For covariate with no simulated effects, the full model mainly identified them as non-relevant or with insufficient information while SCM/SCM+ mainly did not select them. SCM/SCM+ assume that non-selected covariates are non-relevant when it could be due to insufficient information, whereas the full model does not make this assumption and is faster. This study must be extended to other methods and completed by a more complex high-dimensional simulation framework.
Participants will order groceries sufficient to meet their caloric needs each week for 12 weeks with the assistance of a dietitian/nutrition interventionist. Groceries will be delivered to participants' homes or picked up at a convenient location. The dietitian/nutrition interventionist will provide brief educational content at the time of food delivery. Orders will be placed via phone or through virtual counseling sessions. During the remainder of the study (months 4-12), participants will be asked to apply what they learned without the provision of groceries.
Circulating tumor DNA (ctDNA) refers to small fragments of DNA released into the bloodstream by cancer cells. It is obtained through "liquid biopsy;" which most commonly refers to plasma or blood samples, but can be obtained from a number of bodily fluids including ascitic fluid, saliva, and even urine and stool. ctDNA is detected via polymerase chain reaction (PCR) or next-generation sequencing (NGS). The DNA from these samples is analyzed for the detection of point mutations, copy-number alterations, gene fusion, and DNA methylation. These results have the potential for use in cancer diagnosis, determining prognosis, targeting gene-specific therapies, and monitoring for/predicting disease recurrence and response to treatment. ctDNA offers an alternative to tissue biopsy; it is less invasive and can be monitored serially over time without multiple procedures. Moreover it may have the ability to detect disease recurrence or predict behavior in a way that solid tissue biopsies, tumor marker surveillance, and imaging cannot. Recent explosion in interest in ctDNA shows promising developments for widespread adoption of these techniques in cancer care. However, the use of ctDNA in diagnosis and treatment of gynecologic malignancies is currently limited, compared to adoption in other solid-organ tumors such as breast and colorectal cancers. Compared to other cancer types, there appear to be fewer comprehensive studies and clinical validations specifically focusing on the use of ctDNA in gynecologic cancers. More research is needed in this area to advance the potential for use of ctDNA in ovarian, endometrial, and cervical cancers before this can be routinely adopted to improve care for patients with gynecologic malignancies.
Methadone may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is an increased risk in patients whose ability to maintain normal blood pressure is compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g. phenothiazines or general anesthetics) [see Drug Interactions (7)]. Monitor these patients for signs of hypotension after initiating or titrating the dosage of methadone hydrochloride tablets for oral suspension. In patients with circulatory shock, methadone hydrochloride tablets for oral suspension may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of methadone hydrochloride tablets for oral suspension in patients with circulatory shock.
Individuals may decide to participate in the research study and agree to be randomized. These individuals will be immediately randomized into an immediate or a wait list control group. The immediate will receive the independent transfer training program after completing the baseline questionnaires. The wait list control group will wait approximately 6 months before receiving the independent transfer training program.
PURPOSE: A microwave oven is provided to simultaneously heat with microwaves and far-infrared rays by sticking irradiating elements of far-infrared rays. CONSTITUTION: Many irradiating rods of far-infrared rays(1) are stuck in an upper part and a wall of a microwave chamber. Reflecting mirrors of far-infrared rays(102) are installed in the back of the rods(1). Opening/closing devices(103) of far-infrared irradiation are installed in front of the rods(1). A perspective screen having a far-infrared reflecting face is installed inside a perspective window. Thereby, a roasting characteristic of a gas oven or an electric oven is contained in the microwave oven. Therefore, the function of the microwave oven is improved and cooking methods of the microwave oven is diversified.
SRY-related HMG-box gene 11 (SOX11) is a transcription factor overexpressed in mantle cell lymphoma (MCL), a subset of Burkitt lymphomas (BL) and precursor lymphoid cell neoplasms but is absent in normal B cells and other B-cell lymphomas. SOX11 has an oncogenic role in MCL but its contribution to BL pathogenesis remains uncertain. Here, we observed that the presence of Epstein-Barr virus (EBV) and SOX11 expression were mutually exclusive in BL. SOX11 expression in EBV-negative (EVB-) BL was associated with an IG∷MYC translocation generated by aberrant class switch recombination, whereas in EBV-negative (EBV-)/SOX11-negative (SOX11-) tumors the IG∷MYC translocation was mediated by mistaken somatic hypermutations. Interestingly, EBV- SOX11-expressing BL showed higher frequency of SMARCA4 and ID3 mutations than EBV-/SOX11- cases. By RNA sequencing, we identified a SOX11-associated gene expression profile, with functional annotations showing partial overlap with the SOX11 transcriptional program of MCL. Contrary to MCL, no differences on cell migration or B-cell receptor signaling were found between SOX11- and SOX11-positive (SOX11+) BL cells. However, SOX11+ BL showed higher adhesion to vascular cell adhesion molecule 1 (VCAM-1) than SOX11- BL cell lines. Here, we demonstrate that EBV- BL comprises 2 subsets of cases based on SOX11 expression. The mutual exclusion of SOX11 and EBV, and the association of SOX11 with a specific genetic landscape suggest a role of SOX11 in the early pathogenesis of BL.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic composition containing a soybean-derived components, excellent in humectant property, anti-inflammatory effect and beautifully whitening effect, also accelerating metabolism and having an anti-aging effect, and a method for producing the same.  <P>SOLUTION: This cosmetic composition is constituted by a protein-containing coagulated material obtained by performing a sedimentation treatment for an aqueous extract of soybean. The cosmetic composition may be performed with an emulsification treatment. Another cosmetic composition is constituted by a fermented product by microorganisms or an enzyme-treated material of the protein-containing coagulated material obtained by performing the sedimentation treatment for the aqueous soybean extract. As the aqueous soybean extract, soybean milk is preferably used.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
FIELD: cosmetology, pharmacology. SUBSTANCE: the suggested innovation deals with manufacturing cosmetic, curative-cosmetic, pharmacological preparations and food additives. Chitosan- or chitosan suspension-based biologically active composition has nanogranules at their sizes not exceeding 100 nm; it contains components of plant and/or animal origin, and/or vitamins, and/or minerals, and/or artificial and synthetic preparations used in the field of cosmetology, curative cosmetology, pharmacopoeia and food industry. The content of gel or suspension in composition is not less than 10 weight%. The present innovation enables to increase penetrating capacity and activity of the composition suggested. EFFECT: higher efficiency. 13 cl
In this project we aim to treat the posttraumatic stress disorder (PTSD) symptoms among Syrian refugees through an effective psycho-therapy technique called Eye Movement Desensitization and Reprocessing (EMDR). Randomly selected refugees will be assessed through MINI PLUS for the diagnose of PTSD. Eighty refugees with PTSD will be randomly allocated to either 7 sessions EMDR or wait-list control group.Symptoms of PTSD (MINI PLUS, HTQ, IES-R) and depression and anxiety (BDI, HSCL)will be assessed at pre- and post-treatment and 4 weeks follow-up.

However, to our knowledge this is one of the first intervention studies which will be conducted in a refugee camp. Therefore we expect to have some practical and logical problems. In order to see the feasibility and efficacy of EMDR among Syrian refugees, before the main study we aim to run a pilot study with less participants. In the pilot we will assess the posttraumatic stress symptoms with Impact of Event Scale-Revised (IES-R) and the depressive symptoms through Beck Depression Inventory (BDI-II).
This is a single arm study. All participants completed the study interventions which are pembrolizumab treatment, FDG PET, C11-AMT PET and CT scans.
FIELD: medicine, endocrinology. SUBSTANCE: invention relates to long-term modification and regulation of lipid and carbohydrate metabolism at insulin-nondependent diabetes mellitus, or type-2. Method involves oral, sublingual or parenteral administration of bromocriptin (dopamine agonist) to human or animals. Bromocriptin is administrated depending on normal circadian rhythm of insulin-resistant and insulin-sensitive persons or animals. Resistance to insulin, hyperinsulinemia and hyperglycaemia or both can be regulated in human on long-term base using this treatment since short-term daily administration of preparation corrects hormonal "schedule" in brain nervous centers that results to long-term effect. EFFECT: enhanced effectiveness of method. 20 cl, 4 tbl
Participants will be assigned to either a) three sessions of virtual reality-based intervention aimed at improving police interaction skills or b) no intervention. Assessments of police skills will occur before intervention, after intervention, and 3-4 weeks follow up in the intervention group and at comparable timepoints in the no intervention group.
FACE-PC comprises 3 weekly and 2 bi-weekly sessions (total 5 sessions), delivered by a bachelors' prepared nurse care manager (CM) over 8 weeks. Over the five sessions, the nurse care manager will (1) review the patient medical history and set health goals for depression and chronic condition with the dyad, (2) review all medication, the level of adherence, challenges and facilitating factors of adherence, (3) deliver brief behavioral activation therapy.
The integrity of the lymphatic system is critical for preventing the dissemination of tumor cells, such as melanoma, to distant parts of the body. IFN-γ is well studied as a negative regulator for lymphangiogenesis, which is strongly associated with cancer metastasis. However, the exact mechanisms underlying this process remain unclear. In the present study, we investigated whether IFN-γ signaling in lymphatic endothelial cells (LECs) affects tumor cell dissemination by regulating the barrier function of tumor-associated lymphatic vessels. Using LEC-specific IFN-γ receptor (IFN-γR) knockout mice, we found that the loss of IFN-γR in LECs increased the dissemination of melanoma cells into the draining lymph nodes. Notably, IFN-γ signaling in LECs inhibited trans-lymphatic endothelial cell migration of melanoma cells, indicating its regulation of lymphatic barrier function. Further investigations revealed that IFN-γ upregulated the expression of the tight junction protein Claudin-3 in LECs, while knockdown of Claudin-3 in LECs abolished IFN-γ-induced inhibition of trans-lymphatic endothelial migration activity. Mechanistically, IFN-γ inhibits AMPK signaling activation, which is involved in the regulation of fatty acid metabolism. Modulating fatty acid metabolism and AMPK activation in LECs also affected the lymphatic dissemination of melanoma cells, further confirming that this process is involved in IFN-γ-induced regulation of lymphatic barrier function. These results provide novel insights into how IFN-γ modulates tight junctions in LECs, inhibiting the dissemination of melanoma cells via the lymphatic vessels.
The invention discloses a traditional Chinese medicine formula for treating gastric cold and a preparation of the traditional Chinese medicine formula. The traditional Chinese medicine formula is prepared from rhizoma corydalis, cuttle bone and cortex cinnamomi. The compatibility of the traditional Chinese medicine formula is as follows: 20-30g of the rhizoma corydalis, 20-30g of stir-baked rhizoma atractylodis macrocephalae with soil, 20-30g of the cuttle bone and 40-60g of the cortex cinnamomi. The preparation method of the traditional Chinese medicine formula for treating the gastric cold comprises the following steps: decocting 20-30g of the rhizoma corydalis, 20-30g of stir-baked rhizoma atractylodis macrocephalae with soil, 20-30g of the cuttle bone and 40-60g of the cortex cinnamomi with 160-480g of water above slow fire for 10-30min, filtering and reserving a filtrate, so that a finished product is obtained. The traditional Chinese medicine formula disclosed by the invention has functions of promoting digestion, clearing away heat and toxic materials, eliminating stagnation and the like. The traditional Chinese medicine formula is mainly used for treating gastroptosis and edema; and the traditional Chinese medicine formula has the characteristics of being short in treatment course, high in cure rate, not easy for reoccurrence and the like.
Musculoskeletal (MSK) pain is a common reason for consultation in general practice and frequently reported in children and adolescents. This study examined the prevalence of MSK pain in 13-year-old children and assessed associations with physical and psychosocial factors. Data from the Generation R Study, a population-based birth cohort, was used. Prevalence and characteristics of MSK pain were assessed, using a pain mannequin, at 13 years of age (N = 3062). Demographics and data on physical activity, sedentary behaviors, previous reported MSK pain, and behavioral problems were extracted from questionnaires. The body mass index (BMI) SD-score was calculated from objectively measured weight and height. A prevalence of 23.3% was found for MSK pain in children of which 87.2% persisted for more than 3 months (ie, chronic), 45.5% experienced pain daily. More physically active children and children with a higher BMI reported MSK pain more frequently compared with non-MSK pain and no pain. The knee was the most often reported location. Children with MSK pain were more likely to have reported MSK pain at 6 years. Multivariable analyses showed significant associations for male sex (OR 0.74, 95% CI 0.56-0.98), high maternal educational (OR 0.69, 95% CI 0.49-0.96), higher BMI (OR 1.19, 95% CI 1.05-1.35), being physically active (OR 1.41, 95% CI 1.03-1.91), and behavioral problems (OR 1.85, 95% CI 1.33-2.59) with the presence of MSK pain. The chronic nature of MSK pain in combination with the relatively high prevalence of MSK pain in this study shows that MSK pain is already an important problem at a young age.