anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The method for treating the bronchial asthma with the concomitant chronic cholecystitis provides for taking into account the characteristic features of the course of concomitant chronic cholecystitis. The activity spectrum of the drugs used for the basic therapy of the bronchial asthma is considered, and those drugs are preferred, which affect concurrently both the motile and evacuative function of the biliary tract and the bronchial tree. Such drug selection allows one to prevent polypragmasy. The antibacterial therapy is given when the significant inflammation is evident, the bacteria from the gall bladder are isolated, and the sputum is discharged. In the cases of the hypokinetic dyskinesia, Erythromycin is preferred since this drug combines antibacterial and prokinetic activities. In the cases of the hyperkinetic dyskinesia, the synthetic Penicillins or Cyftriaxon is preferred due to their accumulation in the gall bladder.
Participants who remain on their current Disease Modifying Therapies (DMTs) without any changes. DMTs include \~14 formulations/doses of drugs approved in the US by the FDA that alter the natural history of the disease.
The invention discloses a separating and purifying method of an anticancer effective part of Korean folk medicament Artemisia sacrorum Ledeb.. In the method, the overground part of Artemisia sacrorum Ledeb. is adopted as a raw material. The process flow is mainly divided into three parts of organic solvent extraction, filtration and extraction. In the invention, the organic solvent extracting condition and filtration and extracting conditions for the Artemisia sacrorum Ledeb. are established. The Artemisia sacrorum Ledeb. is a Korean folk medicament for treating diseases, such as hepatitis, liver cancer, and the like in the folk; and on the basis of folk application, it is proved by an in-vitro cell test that an Artemisia sacrorum Ledeb. dichloromethane extract can obviously inhibit the growth of a human hepatoma cell HepG2, a human colorectal cancer cell HT-29 and a human breast cancer cell MCF-7 and has better research and development prospect. The method of the invention has simple process, safety and low cost and is suitable for industrialized production. The invention lays the foundation for the deep research of a chemical component structure, pharmacological activity and a medicament preparation of the Artemisia sacrorum Ledeb..
Cardiovascular disease remains the leading cause of death worldwide, with air pollution's impact on cardiovascular health being closely monitored. However, the specific effects of air pollution on the risk of hospital readmission for heart failure (HF) in patients with unstable angina (UA) have not been fully explored. We conducted a retrospective study involving 12,857 consecutive patients diagnosed with acute coronary syndrome (ACS) between January 2015 and March 2023. After rigorous screening, we included 8,737 patients with UA in the analysis. Furthermore, we used a Cox proportional hazards regression model to examine the relationship between air quality indicators and hospital readmission for HF in patients with UA. Additionally, a decision tree model identified air quality indicators levels that had the most significant impact on readmission for HF risk. After adjusting for confounding factors, we found that elevated levels of PM10 [hazard ratio (HR) = 1.003, 95% confidence interval (CI): 1.000-1.005, p = 0.04453] and CO (HR = 1.013, 95% CI: 1.005-1.021, p = 0.00216) were associated with an increased risk of hospital readmission for HF in UA patients. Specifically, patients exposed to PM10 levels above 112.5 µ g/m3 had a 1.61-fold higher risk of readmission for HF in UA patients. (HR = 1.609, 95% CI: 1.190-2.176, p = 0.00201), and those exposed to CO levels above 37.5 mg/m3 had a 2.70-fold higher risk of readmission for HF in UA patients. (HR = 2.681, 95% CI: 1.731-4.152, p < 0.00001). Higher concentrations of PM10 and CO significantly increased the risk of HF (HF) readmission in patients with UA after discharge, particularly when PM10 levels exceeded 112.5 ug/m3 and CO levels surpassed 37.5 ug/m3. Besides, female patients with UA, with fewer underlying diseases, were more susceptible to the adverse effects of PM10 and CO.
The optimal surgical approach of incarcerated and strangulated inguinal hernia is controversial. Retrospective studies showed that surgical approaches through lower abdominal median incision or laparoscopic are superior to the oblique inguinal incision, respectively. Whether transabdominal laparoscopic approach is superior to the lower abdominal median incision approach needs prospective research.Prospective comparative study of patients with incarcerated and strangulated groin hernia admitted to Jinshan hospital for emergency surgery from January 2018 to June 2022. They were divided into two groups according to different surgical approach. The open preperitoneal repair group (OPR) was operated through the lower abdominal median incision. Laparoscopic preperitoneal repair group (TAPP) was completed under transabdominal laparoscope. The perioperative complications and long-term results of the two groups were compared and analyzed. Eighty-two patients met the inclusion criteria, 40 in OPR group and 42 in TAPP group. Baseline data of the two groups were comparable. Thirteen cases (15.9%) of the two groups underwent intestinal resection and anastomosis. Seventy cases (90.2%) underwent the 1st stage mesh repair, including 5 cases of preperitoneal hernioplasty after intestinal resection. The average operation time of TAPP group was 13 min longer (60.7 ± 13.7 min vs 47.8 ± 19.8 min P < 0.001), and the visual analogue scale pain score at 24 h after operation was lower (3.5 ± 1.2 vs 4.4 ± 1.7 P = 0.019) than that of OPR group. There was 1 case of bladder injury (2.5%) in OPR group and 1 case of inferior abdominal artery injury (2.4%) in TAPP group. There was no difference in the rate of the 1st stage hernioplasty between the two groups. In OPR group, 2 cases (5%) extended the incision for more than 2 cm, while in TAPP group, 1 case (2.4%) converted to laparotomy. The time of hospital stay (3.2 ± 1.8 d vs 4.3 ± 2.7 d, P = 0.036) and return to normal activities (7.9 ± 2.7 d vs 11.0 ± 4.4 d, P < 0.001) were shorter in TAPP group. The rate of total postoperative complications including chronic pain, surgical-site infection, seroma, hernia recurrence and so on was 11.9% in TAPP group, which was not significantly different from 25% in OPR group (P = 0.212). There were no cases of mesh related infection and death within 30 days in both groups.TAPP is safe and feasible for the operation of acute incarcerated inguinal hernia. TAPP had better comfort and faster recovery over open preperitoneal repair for the appropriate patients with incarcerated/strangulated inguinal hernia, which can reduce acute pain, shorten hospital stay and return to normal activities earlier.
BACKGROUND: Oral cancer is one of the most common malignancies in the head and neck region. Approximately 90% of oral cancers are oral squamous cell carcinomas (OSCC). 18F-FDG PET/CT has been used in OSCC patients for its high value in detecting metastatic lymph nodes and distant metastases. PET radiomics and sarcopenia can be measured on the PET and CT components of 18F-FDG PET/CT.
PURPOSE: This study aimed to investigate the prognostic value of radiomics and sarcopenia measured on the PET and CT components of pre-operation 18F-FDG PET/CT in OSCC.
METHODS: A total of 116 patients eventually enrolled in our study were randomly divided into two cohorts: training cohort (n = 58) and validation cohort (n = 58). The Cox model combined with the least absolute shrinkage and selection operator (LASSO) algorithm was applied to construct the radiomics score (Rad_score). The third lumber skeletal muscle index (L3 SMI) was calculated to identify sarcopenia. Univariate and multivariate Cox regression analyses were performed to identify the independent prognostic factors. Based on the clinical factors, the clinical model was constructed, and the combined model was developed through the combination of the clinical model and Rad_score. C index, time-dependent C-index curves, receiver operating characteristic (ROC) curve, calibration curves, and decision curve analysis were used to evaluate the performance of prediction models.
RESULTS: Three radiomics features constitute the Rad_score for overall survival (OS) and progression-free survival (PFS), respectively. Multivariate Cox regression analysis revealed that Rad_score was an independent prognostic factor, whereas sarcopenia was not. The combined models showed satisfactory performance in both the training cohort (C-index: OS:0.836, PFS:0.776) and the validation cohort (C-index: OS:0.744, PFS:0.712). The combined models were visualized as nomograms. Nomogram scores can realize the risk stratification of OSCC patients. Lower nomogram score is significantly related to the poorer OS (training cohort: p < 0.0001, validation cohort: p < 0.0001, overall cohort: p < 0.0001) and PFS (training cohort: p < 0.0001, validation cohort: p = 0.00017, overall cohort: p < 0.0001).
CONCLUSIONS: Rad_score, but not sarcopenia, was an independent prognostic factor for patients with OSCC. The nomograms had a satisfactory performance, which might be helpful for OSCC patients and clinicians in personalized prognostic prediction and treatment decision-making.
JNJ-26866138 0.7 mg/m2 on Days 1, 4, 8, 11, 22, 25, 29 and 32 of 6-week cycle up to 4 cycles. Melphalan 9 mg/m2 and Prednisolone 60 mg/m2 on Days 1, 2, 3 and 4 of 6-week cycle up to 4 cycles.
A detecting, monitoring and reporting system includes a sensor device which generates data indicative of at least one of activity, GSR and heat flow of an individual and data derived therefrom when placed in proximity with the body. A remote central monitoring unit generates analytical status data from this data and analytical status data that has previously been generated. A data storage device stores the data received and generated by the central monitoring unit. The system includes means for establishing electronic communication between the sensor device and the central monitoring unit, and means for transmitting the data to a recipient. The sensor device may also generate data indicative of contextual parameters of the individual, which may then be used when generating the analytical status data. The system may be used for monitoring and providing feedback relating to the degree to which an individual has followed a suggested routine.
A method for providing guided meditation to a user in a virtual reality environment is provided. A user selects a type of meditation, time duration of meditation, and location of meditation. Based on the user's selections, the VR guided meditation system provides a guided meditation exercise and a VR environment to a client device. The guided meditation exercise includes audio instructions guiding the user through meditation steps. The VR environment includes imagery corresponding to the selected location for the meditation exercise, for example, imagery of a beach, waterfall, or trees. The VR guided meditation system also generates reports including statistics of data from a population of users completing guided meditation exercises. For instance, the population of users includes employees of an employer. The report is provided to the employer for the employer to track workplace wellness of the employees.
Group of infants aged 6-7 months that given organic formula milk three times a day for three months. Each serving contains 7 spoons (1 spoon contain 4,6 grams) of milk powder and 210 ml of water.
This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol-eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends. The S-nitrosothiols incorporated to the polymer coatings are mainly primary S-nitrosothiols, characterized by the fact of the nitric oxide (NO) molecule being covalently bound to a sulfur (S) atom which, in turn, is linked to a primary carbon in the molecule's structure, thus constituting the S—NO chemical group. The coating processes include immersion of the stents in polymer solutions containing S-nitrosothiols and nebulization processes of the polymer solutions containing S-nitrosothiols onto the stent surface.
The present invention relates to 'health strengthening tea '. Dozens of kinds of traditional Chinese medicines having the effects of health care and cure on human bodies is selected from 'traditional Chinese medicine thesaurus 'according to traditional Chinese medical science theories and western medical science theories. Through a lot of years of repeating research and experiments, several kinds of medicines are finally determined and prepared into the drink. The 'health strengthening tea ' is prepared from 10 to 12g of fructus, 10 to 12g of slenderstyle acanthopanax bark, 4 to 6g of liquorice, 4 to 6g of fructus lycii, 4 to 6 of seaweed, 4 to 6 of starwort root, 4 to 6 of blaeberry, 20 to 25g of tea, 125 to 150g of white sugar and 2500 ml of boiled water. The drink has the following characteristics that the drink can improve the intelligence and the physical strength of people for improving work efficiency, enhance the resistivity of organisms to harmful stimulation, and regulate pathologic processes. The drink can enhance the vision of normal people and patients with eye diseases and reduce the concentration of blood serum ornitrol, and has the effect of tumor resistance. Therefore, the drink can improve the life quality of people and prolong the lifetime of people. The drink has the advantages which can not be replaced by other drinks on markets, and simultaneously, has the characteristics of novelty, scientificalness, applicability, economy, etc.
Women with no cancer recruited from the population residing in the same cities for at least 3 years and matched to cases on age (+/- 5 years) and health care institution. For each subject, complete questionnaire data on socio-demographic factors, health and reproductive history, early risk factors, physical activity, diet, occupation, environmental risk factors, ethnicity, and family history of cancer are collected. Validated and standardized food frequency questionnaires are administered to gather information on diet. Anthropometry is measured according to standardized protocols. Blood and urine samples are also collected for biomarker analyses.
Patients in the single agent glioma dose expansion arm will receive a single IV dose of 2B3-101 on day 1 of each cycle. In order to minimize the risk of infusion reactions 5% of the total dose of 2B3-101 (in mg) should be infused slowly over the first 30 minutes. If tolerated, the infusion may then be completed over the next hour for a total infusion time of 90 minutes.
INTRODUCTION: Adverse childhood events (ACEs) have been linked to widespread chronic pain (CP) in various cross-sectional studies, mainly in clinical populations. However, the independent role of different ACEs on the development of different types of CP remains elusive. Accordingly, we aimed to prospectively assess the associations between specific types of ACEs with the development of multisite CP in a large population-based cohort.
METHODS: Data stemmed from the three first follow-up evaluations of CoLaus|PsyCoLaus, a prospective population-based cohort study of initially 6734 participants (age range: 35-75 years). The present sample included 1537 participants with 2161 analyzable intervals (49.7% men, mean age 57.3 years). Diagnostic criteria for ACEs were elicited using semi-structured interviews and CP was assessed by self-rating questionnaires. Multinomial logistic regressions with generalized estimating equations method analyzed the relationship between the different ACEs measured in the beginning of the interval and the risk of developing multisite CP during the follow-up. Sensitivity analyses were performed to assess the predictive value of ACEs on multisite CP with neuropathic features.
RESULTS: Participants with a history of parental divorce or separation had an increased risk of developing multisite CP at during follow-up in comparison to those without (RR1.98; 95% CI 1.13-3.47). A strong association was highlighted between parental divorce or separation and the risk of subsequent CP with neuropathic characteristics (RR 4.21, 95% CI 1.45-12.18).
CONCLUSION: These results highlight the importance of psychotherapeutic management of people experiencing parental separation to prevent CP in the future.
A cosmetic composition for temporarily reshaping keratin fibres, comprising at least one cationically modified guar derivative with a weight-average molecular weight in the range of 5,000-200,000 and a degree of cationic substitution in the range of from 0.1-2; and at least one vinylcaprolactam-containing copolymer. Preferably, the guar derivative is guar hydroxypropyltrimonium chloride. The vinylcaprolactam copolymer may be a copolymer comprising a vinylcaprolactam unit, a vinylpyrrolidone unit, and a dialkylaminoalkyl (meth)acrylamide unit, most preferably, a vinylcaprolactam/vinylpyrrolidone/dimethylaminoethyl methacrylate (DMAEM) copolymer or a vinylcaprolactam/vinylpyrrolidone/dimethylaminopropyl acrylate (DMAPA) copolymer. The composition may also comprise an organic acid. The use of the cosmetic composition for the temporary styling of keratin fibres is disclosed, as is a method for temporarily styling keratinous fibres, in which the cosmetic composition is applied to the keratin fibres, preferably hair, and the shape of the fibres is set. The cosmetic composition aims to provide a styling agent with long-term hold and high curl retention in humid conditions.
Patients undergo Total-Body Irradiation (TBI) twice daily on days -10 to -8 and and donor lymphocyte infusion (DLI) on day -6. Patients receive cyclophosphamide IV on days -3 and -2, tacrolimus IV beginning on day -1 and then orally at least 2 or 3 days prior to discharge with taper starting on day 42, and mycophenolate mofetil IV twice daily on days -1 to 28. Patients undergo Allogeneic Hematopoietic Stem Cell Transplantation on day 0.
The patients included in this group will receive a loading dose of 25 mg of Empagliflozin at the time of enrollment in the study, prior to percutaneous coronary intervention. Over the following three days, they will receive a daily maintenance dose of 10 mg of Empagliflozin.
Right heart failure is a common complication after cardiac surgery, and its mortality remains high. The medical management and veno-arterial extracorporeal membrane oxygenation has shown significant improvement in the majority of cases. However, a minority of patients may still require long-term mechanical circulatory support or heart transplantation. Balloon atrial septostomy is a new method for the prevention and treatment of right heart failure, which may avoid the patient's dependence on mechanical circulatory support. We used this method to try to treat patients with right heart failure after cardiac surgery, and all received good benefits. Therefore, we selected several representative cases to report, in order to guide other qualified cardiac surgeons to carry out relevant clinical practice.
The invention also provides an integrated system that combines an ablation system used in the electrophysiology (EP) lab with a novel, body-worn monitor and data-management software system. The body-worn monitor differs from conventional monitors in that it measures stroke volume (SV) and cardiac output (CO) in addition to heart rate (HR) and ECG waveforms. The combined system collects numerical and waveform data from patients before, during, and after an EP procedure, thereby providing a robust data set that can be used for a variety of analytics and reporting purposes. The body-worn monitor can be applied to the patient immediately after the EP procedure, e.g. while they are recovering in a hospital. Once applied, the body-worn monitor measures data in real-time, and transmits them to both an EMR and a software application running on a mobile device, such as a smartphone, tablet, or personal digital assistant.
BACKGROUND: Febrile urinary tract infections in children are typically treated with a standard 10-day course of antibiotics. However, prolonged antibiotic use can lead to increased bacterial resistance, underscoring the need to explore shorter treatment regimens. This study aimed to compare the short-term therapeutic effects of amoxicillin-clavulanic acid and ceftriaxone sodium in children under five years old with febrile urinary tract infections.
METHODS: Clinical data from 109 children under five years old diagnosed with febrile urinary tract infections between August 2022 and December 2023 were retrospectively analyzed. Among them, 52 children received ceftriaxone sodium (group A), and 48 children received amoxicillin-clavulanic acid (group B). Clinical symptoms, laboratory indicators, clinical efficacy, and adverse reactions were compared between the two groups.
RESULTS: Children from group B showed significantly shorter improvement times for fever, dysuria, and urinary frequency compared to those in group A (p < 0.05). Initially, there were no significant differences in the levels of white blood cell counts, squamous epithelial cells, bacteria, interleukin-6, interleukin-8, and neutrophil gelatinase-associated lipocalin between the two groups (p > 0.05). However, after treatment, group B exhibited significantly lower levels of white blood cell counts, squamous epithelial cells, bacteria, interleukin-6, interleukin-8, and neutrophil gelatinase-associated lipocalin compared to group A (p < 0.05). Moreover, the total effective rate was significantly higher in group B (95.83%) than in group A (80.77%) (p < 0.05). There was no significant difference in the incidence of adverse reactions between groups B (10.42%) and A (13.45%) (p > 0.05).
CONCLUSIONS: Amoxicillin-clavulanic acid demonstrated superior short-term therapeutic efficacy for febrile urinary tract infections in children under five years old compared to ceftriaxone sodium. It effectively reduced cure times, mitigated inflammatory responses, and improved treatment outcomes, suggesting its potential for broader clinical application and adoption.