anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A complex formulation containing aspirin and niacin is provided to ensure convenience administration and reduce side effects of the niacin and aspirin. CONSTITUTION: A complex formulation contains aspirin and niacin which are coated with enteric polymer. The complex formulation is an inner cored-tablet containing aspirin, and cored-tablet with outer layer of niacin. The enteric polymer is hydroxypropylmethylcellulose phthalate or metacrylic acid copolymer. A granule having the inner core-tablet and outer layer further contains excipient, binder, lubricating agent or disintegrant. The excipient is starch, sorbitol, citric acid, mannitol, sucrose, colloidal silica, spray dried-lactose, anhydrous lactose, dibasic calcium phosphate or micro crystalline cellulose. The disintegrant is lactose, starch, sodium starch glycolate, crospovidone, croscarmellose sodium or maltodextrin.
Drug Dependence. Pentazocine can cause a physical and psychological dependence. (See DRUG ABUSE AND DEPENDENCE.)

Head Injury and Increased Intracranial Pressure. As in the case of other potent analgesics, the potential of pentazocine for elevating cerebrospinal fluid pressure may be attributed to CO2 retention due to the respiratory depressant effects of the drug. These effects may be markedly exaggerated in the presence of head injury, other intracranial lesions, or a pre-existing increase in intracranial pressure. Furthermore, pentazocine can produce effects which may obscure the clinical course of patients with head injuries. In such patients, pentazocine must be used with extreme caution and only if its use is deemed essential.

Usage with Alcohol. Due to the potential for increased CNS depressant effects, alcohol should be used with caution in patients who are currently receiving pentazocine.

Patients Receiving Narcotics. Pentazocine is a mild narcotic antagonist. Some patients previously given narcotics, including methadone for the daily treatment of narcotic dependence, have experienced withdrawal symptoms after receiving pentazocine.

Certain Respiratory Conditions. Although respiratory depression has rarely been reported after oral administration of pentazocine, the drug should be administered with caution to patients with respiratory depression from any cause, severely limited respiratory reserve, severe bronchial asthma, and other obstructive respiratory conditions, or cyanosis.

Acute CNS Manifestations. Patients receiving therapeutic doses of pentazocine have experienced hallucinations (usually visual), disorientation, and confusion which have cleared spontaneously within a period of hours. The mechanism of this reaction is not known. Such patients should be very closely observed and vital signs checked. If the drug is reinstituted, it should be done with caution since these acute CNS manifestations may recur.
Cervical cancer (CC) is one of the deadliest gynecological cancers worldwide. Human papillomavirus is the main etiological agent responsible for the initiation and development of most CC cases. The standard method utilized for CC screening in the global population is the cytological Pap smear test. Despite its effective validity in detecting precancerous lesions and its response to layer stages of this disease, greater screening and diagnostic reliability are needed, as well as an improvement in specificity and sensitivity. In this context, the use of liquid biopsies, like blood, for the isolation of circulating tumor DNA (ctDNA) in CC screening, diagnosis, prognosis, and surveillance could fill the gaps that still exist. In the present review, we aim to study the literature in order to collect knowledge on blood-based liquid biopsy based on descriptions of its precious molecular content and its utilization as a potential tool for CC patients' management. We will mainly focus on the important role of the novel ctDNA and the unique possibilities to additionally use HPV-ctDNA in CC at various stages of clinical application.
The invention relates to Chinese herbal medicine pediluvium powder used for treating beriberi, which is especially suitable for a person with beriberi to use and relates to the field of the medical care of life. The Chinese herbal medicine pediluvium powder comprises the main components of saffron crocus, rhodiola root, Tibetan snow lotus, corydalis tuber, coptis root, lignum aloe, rosa banksiae and nard. The Chinese herbal medicine pediluvium powder is a medicament prepared from the following raw materials according to the weight ratio: 4-6 parts of saffron crocus, 5-7 parts of rhodiola root, 3-5 parts of Tibetan snow lotus, 10-12 parts of corydalis tuber, 15-20 parts of coptis root, 1-2 parts of lignum aloe, 1-2 parts of rosa banksiae and 1-2 parts of nard. Pure traditional Chinese medicine medicinal powder is prepared by selecting medicinal materials, removing impurities, processing, pulverizing, sieving, airing and packaging. The invention has excellent formula, obvious effect, simple process and low production cost. The invention can relieve the nerves, promotes blood circulation, kills fungi at the feet effectively, has obvious curative effect to beriberi, dermatophytosis and sweaty feet, exerts the effective components of a medicine by heat effect, cleans the skin at the surface layer, dissolves the keratose of the skin, suppresses each viscera of the whole body and regulates the balance of yin and yang, thereby achieving the aims of externally treating internal diseases and downwards treating upward diseases. The invention is especially suitable for treating beriberi.
Participants receive totally 3 cycles of neoadjuvant therapy (Toripalimab+cetuximab), then radical treatment(surgery). After surgery, Participants receive radiotherapy or chemoradiotherapy according to the pathological results of the operation. Then, participants receive consolidation therapy of Toripalimab.
The invention discloses a new mechanism based on LASS2 gene-mediated renal cancer progression and an early warning application method, which are used for non-disease diagnosis and treatment, including the new mechanism and the early warning application of LASS 2-mediated renal cancer cell proliferation, migration and invasion. The Human Protein Atlas (HPA) database was searched to determine whether las 2 levels had a significant correlation with renal cancer patient survival. The Western blot method detected the protein levels of LASS2 in the renal cancer cell lines 786-O, A-498, caki-1, caki-2, ACHN, RCC4 and SLR21, as well as human renal proximal tubular epithelial cells HK-2. Constructing LASS2 interference/overexpression plasmid, packaging lentivirus, and establishing stable transfer cell strain. The proliferation, migration and invasion conditions of renal cancer cells after the LASS2 gene is knocked down/over-expressed are detected by using a CCK-8 proliferation experiment, a clone formation experiment, a wound healing experiment and a Transwell experiment. Levels of key proteins (MOB 1, YAP, TAZ, c-Myc and SOX 2) in the Hippo pathway were detected by Western Blot using protein identification techniques.
PURPOSE: A dental resin composition containing titanium oxide-based dye and disazo-based dye is provided to implement similar shade with real teeth. CONSTITUTION: A dental resin composition contains host resin, titanium oxide-based dye, and disazo-based dye. The host resin contains polymethyl methacrylate-based resin. The titanium oxide-based dye contains 5.50×10^-4 wt% to 6.50×10^-4 wt% of Ti-Pure Titanium dioxide pigme. The disazo-based dye contains 1.30×10^-6 wt% to 1.70×10^-6 wt% of ORIMAX ORANGE PS. The disazo-based dye further contains ORIMAX RED RR. The dental resin composition further contains Neozapon Black X51. The diazo-based dye is denoted by chemical formula 1.
Ventricular Septal Rupture (VSR) is a rare complication of acute myocardial infarction and has a high mortality rate. Surgery is the definitive treatment. However, in hospitals with limited facilities, treating acute myocardial infarction patients with ventricular septal rupture, is challenging. A 74-year-old woman came to the emergency room of Dr. Koesma General Hospital, Tuban, East Java in December, 2019 with late-onset Acute Myocardial Infarction. On the following day, a new holosystolic murmur was heard in the left lower sternal border with palpable thrill. Transthoracic echocardiography showed VSR with severe pulmonary hypertension. This was followed by a drop in the blood pressure to 80/50 mmHg. The blood pressure was dependent on vasopressors until lisinopril and coenzyme Q10 were introduced. After 3 months, the haemodynamics of the patient were stable. This proved that the use of angiotensin-converting enzyme and coenzyme Q10 promotes more energy production, enables tissue healing and leads to balanced remodelling to increase the survival rate in cases of non-surgical treatment.
Drug Interactions: Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Concurrent use of probenecid with Ampicillin and Sulbactam for Injection USP may result in increased and prolonged blood levels of ampicillin and sulbactam. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with Ampicillin and Sulbactam for Injection and allopurinol administered concurrently. Ampicillin and Sulbactam for Injection USP and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of Ampicillin and Sulbactam for Injection USP
Patients receive G-CSF SC once daily on days 6-11 of each course of chemotherapy as primary prophylaxis. Chemotherapy courses repeat every three weeks for 3-6 courses. Patients may also receive secondary prophylaxis with G-CSF if they experience an episode of neutropenia.
BACKGROUND: Breast cancer (BC) constitutes a significant peril to global women's health. Contemporary research progressively suggests that mitochondrial dysfunction plays a pivotal role in both the inception and advancement of BC. However, investigations delving into the correlation between mitochondrial-related genes (MRGs) and the prognosis and metastasis of BC are still infrequent.
METHODS: Utilizing data from the TCGA database, we employed the "limma" R package for differential expression analysis. Subsequently, both univariate and multivariate Cox regression analyses were executed, alongside LASSO Cox regression analysis, to pinpoint prognostic MRGs and to further develop the prognostic model. External validation (GSE88770 merged GSE425680) and internal validation were further conducted. Our investigation delved into a broad spectrum of analyses that included functional enrichment, metabolic and immune characteristics, immunotherapy response prediction, intratumor heterogeneity (ITH), mutation, tumor mutational burden (TMB), microsatellite instability (MSI), cellular stemness, single-cell, and drug sensitivity analysis. We validated the protein and mRNA expressions of prognostic MRGs in tissues and cell lines through immunohistochemistry and qRT-PCR. Moreover, leveraging the GSE102484 dataset, we conducted differential gene expression analysis to identify MRGs related to metastasis, subsequently developing metastasis models via 10 distinct machine-learning algorithms and then selecting the best-performing model. The division between training and validation cohorts was set at 70% and 30%, respectively.
RESULTS: A prognostic model was constructed by 9 prognostic MRGs, which were DCTPP1, FEZ1, KMO, NME3, CCR7, ISOC2, STAR, COMTD1, and ESR2. Patients within the high-risk group experienced more adverse outcomes than their counterparts in the low-risk group. The ROC curves and constructed nomogram showed that the model exhibited an excellent ability to predict overall survival (OS) for patients and the risk score was identified as an independent prognostic factor. The functional enrichment analysis showed a strong correlation between metabolic progression and MRGs. Additional research revealed that the discrepancies in outcomes between the two risk categories may be attributed to a variety of metabolic and immune characteristics, as well as differences in intratumor heterogeneity (ITH), tumor mutational burden (TMB), and cancer stemness indices. ITH, TIDE, and IPS analyses suggested that patients possessing a low-risk score may exhibit enhanced responsiveness to immunotherapy. Additionally, distant metastasis models were established by PDK4, NRF1, DCAF8, CHPT1, MARS2 and NAMPT. Among these, the XGBoost model showed the best predicting ability.
CONCLUSION: In conclusion, MRGs significantly influence the prognosis and metastasis of BC. The development of dual clinical prediction models offers crucial insights for tailored and precise therapeutic strategies, and paves the way for exploring new avenues in understanding the pathogenesis of BC.
This trial is a randomized, double blind, controlled trial for patients undergoing complex cystometric evaluation. Patients will undergo routine complex cystometric evaluation for acquisition of baseline data using a small amount of intraurethral aqueous jelly for catheter lubrication. Then, they will be randomized to instillation of either placebo (additional intraurethral aqueous jelly, 5ml) or intraurethral 2% lidocaine jelly. Participants then undergo complex cystometry a second time. Normal variations in studies with placebo will be compared to variations within the 2% lidocaine jelly group to determine if cystometric parameters are altered in any clinically important ways. Patient discomfort will also be evaluated by both the patient and the urodynamics advanced practice nurse.
The purpose of the current study is to examine the association between hydration status and cognitive function in middle-aged and older adults, drawing from a large, nationally representative sample in the United States and using a comprehensive set of executive function performance measures. We utilized data from the Health and Retirement Study to conduct twelve, three-stage hierarchical regressions on hydration status and executive function performance of older adults. Cognitive performance scores on the Trail Making A, Symbol Digit Modalities, and Letter Cancellation tests significantly differed by hydration status, and these outcomes follow a curvilinear pattern, such that performance scores are lower for those who are hyper-hydrated or dehydrated relative to those who are euhydrated or near-dehydration. Our study's findings are consistent with prior studies examining the impact of serum osmolarity on cognitive performance. Specifically, a curvilinear pattern was associated with speed of processing tests of executive function. Overall, hydration status is associated with curvilinear patterns of performance on executive function measures, specifically Trail Making A, Symbol Digit Modalities, and Letter Cancellation Tests.
This is a two-part study. Part 1 of the study will optimize and test if a Concordant Care training improves VA clinicians' engagement in recommended practices to provide Concordant Care (i.e., validate, shared understanding, action plan) for Veterans with Long-COVID. The evidence-based Concordant Care approach involves engaging in processes that: 1) validate the patient's experience, 2) develop a shared understanding of the condition, and 3) create a patient-centered, whole health-oriented action plan to manage the condition. Concordant Care will be adapted through interviews and focus groups with Veterans with Long-COVID (estimated n=9) and primary care providers (estimated n=21). Feedback from the participants will help refine and test Concordant Care training. Part 2 of this study will determine if Concordant Care training increases clinicians' engagement in recommended practices to provide Concordant Care and will explore the effectiveness of Concordant Care on care outcomes including satisfaction, adherence to care, \& disability for Veterans with Long-COVID. Part 2 will be a randomized parallel cluster trial with primary care clinicians (n=60) separated into a Concordant Care training group and an education packet control group. Veterans (n=240) who have an upcoming appointment with their primary care provider who is a participant in the study will be recruited. The Veterans will be assessed at baseline before their appointment and approximately 3-months later after their appointment. Veterans treated by clinicians receiving Concordant Care training will report their clinician more frequently engaged in recommended conversations (i.e., ask about Long-COVID, validate experience with Long-COVID, create a shared understanding and action plan), and Veterans will perceive greater shared understanding of Long-COVID with their clinicians than Veterans treated by clinicians in the control arm.
Cryotherapy is a frequently used treatment method in sports medicine and rehabilitation due to its beneficial neuromuscular effects. Its main beneficial effects are motor facilitation, increase isometric force generation, and reduce spasticity. The motor effects of cryotherapy may differ depending on the duration of application, the coolant used agent (ice, ice water, coolant spray, etc.), and the thickness of the subcutaneous adipose tissue. The short-term cold application increases the force of contraction with motor facilitation. As the cold application period gets longer, the effects of the cold that inhibit motor functions such as gamma motor neuron inhibition, muscle spindle inhibition, and muscle conduction block come to the fore.

It is known that the muscle spindle has sympathetic innervation. It has been reported in recent studies that mental arithmetic, cold application to the skin, isometric contraction of remote muscles, and ischemia increase muscle spindle sensitivity through increased sympathetic activity. However, there are very limited studies showing that cold application increases muscle spindle sensitivity through increased sympathetic activity. On the other hand, in terms of determining treatment and rehabilitation strategies, it is important to know how long the effect of the cold application on muscle spindle sensitivity continues. However, it is not clear how long the effect of the cold application on muscle spindle sensitivity lasts after the cold application ends. There is a widespread belief that the motor facilitation effect of cryotherapy can occur with the stimulation of cutaneous cold receptors. Considering this view, it can be thought that the effect of the short-term cold application on muscle spindle sensitivity continues until the skin temperature returns to normal. This research has three hypotheses: First, short-term cold application to the skin increases sympathetic activity. Second, there is an increase in muscle spindle sensitivity with increased sympathetic activity. Third, the effect of short-term cold on muscle spindle sensitivity continues until the skin temperature returns to normal. The purpose of this research is to test these hypotheses.
This is a long-term follow-up observational study of participants who previously received 1.2E11gc/eye of MCO-010. No investigational product will be administered in this study.
Sham rTMS will be applied over the left dorsolateral prefrontal cortex using a sham figure of 8 coil (within-subject crossover). Sham rTMS will consist of the same auditory and tactile stimuli as the active condition, but does not induce an electromagnetic field and does not affect cortical excitability.
Several biochemical mechanisms explaining how Roux-en-Y Gastric Bypass (RYGB) provides an effective treatment for obesity associated type 2 diabetes mellitus (T2DM) and improves hyperglycemia independently of weight loss have been proposed. Two are of particular interest; a) the hindgut hypothesis suggesting that nutrient delivery to the distal intestine drives the production of "incretins" which enhance insulin secretion (e.g. glucagon-like peptide-1 (GLP-1)), and b) the foregut hypothesis, positing that foregut bypass reduces the secretion of factors (i.e. anti-incretins) that normally defend against hypoglycemia. The investigators have been actively investigating this topic and have developed a hypothesis based on past studies that they wish to test in a limited human clinical study. In addition, preclinical data suggest that there exists a gut-to-beta cell pathway, responsive to nutritional tyrosine, regulating insulin secretion, and this pathway provides a mechanism for the early postoperative improvements in hyperglycemia observed in RYGB.
Rationale: The association of acute cellular rejection (ACR) with chronic lung allograft dysfunction (CLAD) in lung transplant recipients has primarily been described before consensus recommendations incorporating restrictive phenotypes. Furthermore, the association of the degree of molecular allograft injury during ACR with CLAD or death remains undefined. Objectives: To investigate the association of ACR with the risk of CLAD or death and to further investigate if this risk depends on the degree of molecular allograft injury. Methods: This multicenter, prospective cohort study included 188 lung transplant recipients. Subjects underwent serial plasma collections for donor-derived cell-free DNA (dd-cfDNA) at prespecified time points and bronchoscopy. Multivariable Cox proportional-hazards analysis was conducted to analyze the association of ACR with subsequent CLAD or death as well as the association of dd-cfDNA during ACR with risk of CLAD or death. Additional outcomes analyses were performed with episodes of ACR categorized as "high risk" (dd-cfDNA ⩾ 1%) and "low risk" (dd-cfDNA < 1%). Measurements and Main Results: In multivariable analysis, ACR was associated with the composite outcome of CLAD or death (hazard ratio [HR], 2.07 [95% confidence interval (CI), 1.05-4.10]; P = 0.036). Elevated dd-cfDNA ⩾ 1% at ACR diagnosis was independently associated with increased risk of CLAD or death (HR, 3.32; 95% CI, 1.31-8.40; P = 0.012). Patients with high-risk ACR were at increased risk of CLAD or death (HR, 3.13; 95% CI, 1.41-6.93; P = 0.005), whereas patients with low-risk status ACR were not. Conclusions: Patients with ACR are at higher risk of CLAD or death, but this may depend on the degree of underlying allograft injury at the molecular level. Clinical trial registered with www.clinicaltrials.gov (NCT02423070).
The invention discloses a medicine for treating diarrhea. The effective ingredients of the medicine contain Radix Astragali, Rhizoma Coptidis, Radix Paeoniae Rubra, Radix Paeoniae Alba, Cortex Fraxini, Semen Persicae, Semen Coicis, Semen Benincasae, Radix Bupleuri, Herba Patriniae and Rhizoma Atractylodis. The medicine has the functions of treating diarrhea with astringents, dispelling cold and clearing heat, and regulating qi and blood and has effects on treating chronic diarrhea, cold-heat jumble and intervisibility of asthenia and sthenia. The paste of the invention is fine, soft and smooth, easy to be coated on cloth and uneasy to melt, and easy for use and carrying because of small size. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.