anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
TLC-C is a modification of an existing TLC-Multi-Disease system that targets patients with multiple chronic diseases combined with a post-hospital discharge intervention (TLC-RED-Lit). TLC-C uses conversational computer telephony to monitor patients' multiple diseases between their ambulatory care visits. The system works in both routine (patient stable) and exacerbation (patient unstable) modes. The system monitors patients through "virtual visits" and detects and notifies clinicians about important clinical problems to attend to. It also promotes patient self-care (e.g., medication adherence and appointment preparation). In emergent situations the system recommends going to the local Emergency Department (ED). In urgent situations, an alert is sent to the clinician or to his/her coverage provider. Exacerbation mode is used when the patient is discharged from a hospital inpatient service or ED or has worsening symptoms. It concentrates on the exacerbating disease and monitors patient status (improved, stable or deteriorating). Daily contact is maintained until the patient's status improves. Routine mode occurs with the patient at their baseline status and monitors the disease and the patients' self-care behaviors.

The investigators propose to perform a multi-method evaluation study of the patients, the providers, and the practice. This includes a 2-arm randomized clinical trial of TLC-C versus usual care for patients with two or more chronic diseases, at least one previous episode of acute hospital utilization over the last 12 months, and who had been recently discharged from an urban hospital. The randomized clinical trial (RCT) will evaluate the system in 440 patients followed for 6 months.

The primary outcome is acute hospital care utilization (unplanned hospitalizations and ED visits). Secondary outcomes include patient quality of life (EuroQol 5D \[EQ-5D\]), satisfaction (Clinician and Group Survey \[G-CAHPS\]), ambulatory appointment show rate and net payer costs. The investigators will explore disease specific metrics (e.g., hemoglobin A1c \[HbA1c\] or blood pressure). The investigators will perform formative and summative qualitative studies of the implementation of the system, its use and performance over time, and its impact on the patients, providers and the practice as a whole.
Chemically stable aqueous dispersions of prothioconazole and processes for preparing them are provided. The dispersions comprise prothioconazole present in an aqueous medium, and a sulfur-containing compound present in an amount effective to render the dispersion chemically stable. The sulfur-containing compound is present in the dispersion in an amount effective to render the dispersion chemically stable as defined above. However, such amounts must be within government regulations for additives to agricultural treatment compositions. The compound must therefore be carefully chosen to be effective while maintaining government guidelines for maximum permissible amounts. Antioxidants such as ascorbic acid, tocopherols, and polyphenols were compared to the sulfur-containing compound used in the process of the present invention, and were found to be either ineffective or may require amounts in excess of government mandates when used without the sulfur-containing compound.
Liver fibrosis is a coordinated response to tissue injury that is mediated by immune cell interactions. A mitochondria-regulated information-processing (MIP) nanosystem that promotes immune cell communication and interactions to inhibit liver fibrosis is designed. The MIP nanosystem mimics the alkaline amino acid domain of mitochondrial precursor proteins, providing precise targeting of the mitochondria. The MIP nanosystem is driven by light to modulate the mitochondria of hepatic stellate cells, resulting in the release of mitochondrial DNA into the fibrotic microenvironment, as detected by macrophages. By activating the STING signaling pathway, the developed nanosystem-induced macrophage phenotype switches to a reparative subtype (Ly6Clow) and downstream immunostimulatory transcriptional activity, fully restoring the fibrotic liver to its normal tissue state. The MIP nanosystem serves as an advanced information transfer system, allowing precise regulation of trained immunity, and offers a promising approach for effective liver fibrosis immunotherapy with the potential for clinical translation.
Soln of title cpd (I): (N,N-oxydimethylenebis (pyridine-4-aldoxime)dichlorides) are prepd by recrystallising I from a solvent (mixt) contg. 0.5-2 wt. % of an aliphatic aldehyde (esp HCHO) are then making the purified I up into injectable solns conventionally opt. esp. where soln has been heat-treated with incorporation of a NH2OH-scavenger at 0.004-1 wt. % on I e.g. 0.001-1 wt. % of an oxo cpd. Pref. 0.004-0.01 wt. % hexamethylenetetramine is also incorporates (to optimum pk). I is a chlorinesteras reactivator used for treating poisoning by nerve gases and insecticides. Solns preppd above do not have the side effects (burning and itching sensations in the perianal and genital region) of known compsn since they do not contain free NH2OH, and remain free from side effects even after prolonged storage.
FE/Formul. = food and formulation effects and relative absorption. Participants will receive two formulations of BMS-986196 (solution and suspension), each formulation with and without food.
STUDY OBJECTIVE: To evaluate the feasibility and benefit of a diagnostic and therapeutic algorithm for management of patients presenting with a high C-reactive protein (CRP) level after colorectal surgery.
PATIENTS AND METHODS: Prospective study including patients with CRP>125mg/L at the 4th postoperative day following elective colorectal surgery. The protocol involved CT-scan of which the results were to orient subsequent management: antibiotics, radiological drainage, endoscopy or surgical redo. Success (primary endpoint) consisted in the proportion of patients with total duration of hospitalization fewer than 15d. Secondary endpoints were: applicability of the protocol in real-life conditions, number of stomas created, duration of hospitalization in an intensive care unit.
RESULTS: One hundred and six (106) patients were included: 51 patients (48%) presented with postoperative complications, of which 21 (41%) were severe. No death occurred. Among the included patients, 68% had a hospital stay<15d. Major deviations from the management algorithm occurred in 38% of cases. No patients had an early endoscopy. There was no significant difference with regard to the secondary endpoints according to whether or not the protocol was strictly observed.
CONCLUSION: It is necessary to define a protocol for management of patients presenting with high CRP levels after colorectal surgery, the objective being to reduce the impact of complications and to avoid excessive lengthening of hospital stay. The protocol begins with CT-scan, which is to orient subsequent management.
Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
PROBLEM TO BE SOLVED: To provide a material for artificial tooth that can miniaturize the molding machine for dental purposes and can improve the moldability and aethetic properties of artificial teeth. SOLUTION: A filler including 70 pts.wt. of polycarbonate, 30 pts.wt. of molten liquid crystalline polyester and 5 pts.wt. of glass fiber as a reinforcing material is fed to the raw material feeding port and extruded through an extruder at 300 deg.C cylinder temperature into pellets. The molten liquid-crystalline polyester is homogeneously dispersed into the polycarbonate matrix in fibrous form thereby high mechanical strength is attained despite that the viscosity of the material is relatively low.
The invention provides a novel fasciola hepatica multi-epitope vaccine. An active ingredient of the novel fasciola hepatica multi-epitope vaccine is a polypeptide. The polypeptide is mainly formed by fasciola hepatica sphingolipid activated mucin-like protein-2 Th, a multicopy body of B-cell epitope and a mucosal immunologic adjuvant cholera toxin B subunit. An artificial gene is mainly synthesized through the gene synthesis technology and comprises Th of sphingolipid activated mucin-like protein-2 and a gene sequence of the multicopy body of the B-cell epitope, then the artificial gene is coupled with the gene sequence of the cholera toxin B subunit, and a fusion gene is formed. An escherichia coli prokaryotic expression system is utilized for expressing the fusion gene, and the fasciola hepatica multi-epitope vaccine is obtained after protein purification. The fasciola hepatica multi-epitope vaccine can induce an organism to generate sphingolipid activated protein T cell immune responses and high-titer specific antibody humoral immune responses, and can be used for preventing and treating fasciola hepatica infection related diseases.
Participants who were continuing their CPP treatment with a non-Enantone gonadotropin releasing hormone agonist (GnRHa) after treatment with Enantone in the follow-up phase (the mean duration of follow up while on another GnRHa was 10.80 months with a range of 2.8 to 20.5 months, and the mean duration of follow up after stopping treatment was 4.26 months with a range of 0.0 \[i.e. 1 day\] to 12 months).
Systems and methods for patient medical history analysis and timeline segmentation are provided. The method includes obtaining a health record of a patient using a plurality of medical devices for a duration of treatment. The health record includes at least one action or event associated with the patient, and the health record is stored in an electronic format. The method also includes identifying a start and an end of at least one action or event associated with the patient using a start-end marker detection module, and marking a start and end boundary of the at least one action or event. The method also includes segmenting the at least one action or event by generating a fuzzy timeline boundary for the at least one action or event using a segment start-end detection module. The method further includes partitioning segment boundaries and arranging the segments in a timeline order.
Sepsis is characterized by a dysfunctional host response to infection culminating in life-threatening organ failure that requires complex patient management and rapid intervention. Timely diagnosis of the underlying cause of sepsis is crucial, and identifying those at risk of complications and death is imperative for triaging treatment and resource allocation. Here, we explored the potential of explainable machine learning models to predict mortality and causative pathogen in sepsis patients. By using a modelling pipeline employing multiple feature selection algorithms, we demonstrate the feasibility of identifying integrative patterns from clinical parameters, plasma biomarkers, and extensive phenotyping of blood immune cells. While no single variable had sufficient predictive power, models that combined five and more features showed a macro area under the curve (AUC) of 0.85 to predict 90-day mortality after sepsis diagnosis, and a macro AUC of 0.86 to discriminate between Gram-positive and Gram-negative bacterial infections. Parameters associated with the cellular immune response contributed the most to models predictive of 90-day mortality, most notably, the proportion of T cells among PBMCs, together with expression of CXCR3 by CD4+ T cells and CD25 by mucosal-associated invariant T (MAIT) cells. Frequencies of Vδ2+ γδ T cells had the most profound impact on the prediction of Gram-negative infections, alongside other T-cell-related variables and total neutrophil count. Overall, our findings highlight the added value of measuring the proportion and activation patterns of conventional and unconventional T cells in the blood of sepsis patients in combination with other immunological, biochemical, and clinical parameters.
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention and/or hyperactivity/impulsivity that are persistent across time and situations. ADHD in adulthood, with estimated prevalence of 2-3%, is associated with challenges that may have severe consequences on daily life functioning. Treatments delivered over the Internet on smartphones or personal computers may help to increase the availability of effective psychological interventions for a larger group of adults with ADHD. The overall aim of this study is to investigate 1) predictors of effect; 2) implementation outcomes; and the 3) cost-benefit of a therapist guided Internet-delivered treatment for adults with an ADHD diagnosis. The study is an open longitudinal cohort trial in routine care. A total of 200 participants with an ADHD diagnosis will be included in the trial, and 15 participants will be interviewed about their experiences with guided Internet-delivered treatment. The outcomes are change in primary and secondary symptoms and quality of life, cost-benefit and implementation outcomes of guided internet-delivered treatment for adults with ADHD. The investigators will use quantitative statistical procedures and qualitative methods to analyze the data. The results from the study will contribute to the growing research on Internet-delivered treatments. The expected results may have a major impact on treatment provision and the further development of treatment options for adults with ADHD. Moreover, investigating ways to increase adoption, adherence and fidelity in Internet-delivered treatment could be of great value when implementing such treatment into routine care.
The present invention belongs to the field of biotechnology, and determines one atrichia gene and its correlation to Kunming mouse depilation characte. The gene is located in No. 14 chromosome of the mouse, has position of 14D1 in cytogenetic map and 39.5 cM in linkage map, full length about 20.281 Kb DNA sequence, transcription product 4017 bp, 19 exons contained, and 1182 coded amino acid residues translated from No.378 m RNa. Sequencing shows that the nonsese mutation in N0. 2817 places of the gene is the gene leading to KIZ depilation of Kunming mouse. In addition, the gene in human genome is also very conservative with the similar function. Therefore, the gene may be used in the research of human baldness mechanism and as the target gene for designing medicine for treating papular baldness.
PURPOSE:To form excellent adhesion interface with cement or adhesive resin by coating liquid gallium alloy over the surface of covering metal. CONSTITUTION:A pure tin rod is covered with a liquid Ga-Sn alloy, for ex. Ga-Sn alloy having a liquid phase point of 20 deg.C and rubbed onto the surface of a covering metal, and now a new alloy layer incl. Ga-Sn is formed on the surface of this covering metal. This process is applied to these alloys with scarce bond force in adhesive resin according to conventional knowledge, and the bond property is measured by a tensile test, which has demonstrated a bond strength exceeding 450kgf/cm<2> with Au/Ag paradium alloy. An examination of the water resistance in an adhesion interface after dipping underwater has revealed that no exfoliation is observed at the interface and the water resistance is very high. On the other hand, application of this process to adhesion of Au alloy with polycarboxylate cement has exhibited a bond strength of 130kgf/cm<2> as measured by tensile test.
Using a non-viral active agent (I), prepared by molecular biological methods, for treatment of acne and acneform skin disorders, including rosacea, is new. Use of a non-viral active agent (I), prepared by molecular biological methods, for treatment of acne and acneform skin disorders, including rosacea. (I) is an antisense oligonucleotide (ASON); (stabilized) ribozyme; (mirror) aptamer; chimeric RNA/DNA oligonucleotide; naked plasmid DNA or DNA encapsulated in a liposome, especially an ASON specific for a gene that encodes a steroid hormone receptor or steroid hormone metabolizing enzyme, particularly the androgen receptor and/or 5alpha -reductase. ACTIVITY : Dermatological; Antiseborrheic. MECHANISM OF ACTION : Antisense inhibition of the androgen receptor and/or 5alpha -reductase gene, and therefore androgen-induced stimulation of sebaceous gland activity. When S295 immortalized human sebocytes were treated with 0.1 MicroM testosterone (T) their proliferation was significanly stimulated. When the cells were incubated for 4 hours with 1 MicroM of the oligonucleotide (S2) directed against the transcription start site of the androgen receptor gene before treatment with T, the stimulatory effect was abolished; the absorbance in an immunoblotting assay for receptor expression was then about 0.6 compared with about 1.2 for cells not treated with T. The oligonucleotide was toxic for the cells.
Previous research have demonstrated that the stress hyperglycemia ratio (SHR) accurately reflects acute hyperglycemic states and correlates with adverse outcomes. This study aims to explore the relationship between SHR and the prognosis of patients with aneurysmal subarachnoid hemorrhage (aSAH). Patients with aSAH were categorized into four groups based on SHR tertiles. Functional outcomes were evaluated at 12 months using the modified Rankin Scale (mRS), with scores ranging from 0 to 2 indicating a good outcome and 3-6 indicating a poor outcome. The associations between SHR and functional outcomes were analyzed using logistic regression models and restricted cubic spline analysis. A total of 127 patients exhibited poor functional outcomes. Following comprehensive adjustments, those in the highest SHR tertile had a significantly increased risk of poor prognosis compared to those in the lowest tertile (odds ratio [OR], 4.12; 95% confidence interval [CI]: 1.87-9.06). Moreover, each unit increase in SHR was associated with a 7.51-fold increase in the risk of poor prognosis (OR, 7.51; 95% CI: 3.19-17.70). Further analysis using restricted cubic spline confirmed a linear correlation between SHR and poor prognosis (P for nonlinearity = 0.609). Similar patterns were observed across all studied subgroups. Elevated SHR significantly correlates with poor functional prognosis at one year in patients with aSAH, independent of their diabetes status.
Children with cardiac arrest (CA) have mortality rates of 50-90%, largely due to neurological failure as part of the post-resuscitation syndrome. There is a critical gap of knowledge and tools to accurately classify outcome after pediatric CA. Physical examination and laboratory testing inadequately assess the severity of neurologic injury and outcome. Hazards of misclassification include risking adverse effects from ineffective therapies and non-treatment of ostensibly well patients who later are found to have neurologic deficits. Early and accurate identification of the eventual severity of neurologic injury would allow for timely neuroprotective interventions and/or more targeted testing of new therapies in specific risk populations. The long term objective is to improve the neurological outcome of children surviving CA. In this study, investigators will model and validate serum and imaging biomarkers of brain injury with empirical support, and assess their accuracy together with clinical variables in classifying outcome after pediatric CA. The central hypothesis is that serum and imaging biomarkers of brain injury, together with clinical variables, will critically aid in the early classification of favorable outcome after pediatric CA (Vineland Adaptive Behavior Scales score \[VABS\] \> 70) 1 year after pediatric CA in a multicenter prospective study (8-12 centers and 248 subjects). Strong preliminary data supports this hypothesis, and biomarkers will be tested for outcome classification accuracy in the following 3 specific aims:

Aim 1) Serum biomarkers of neuronal (neuron specific enolase and ubiquitin carboxy-terminal hydrolase-L1) and glial injury (S100b and glial fibrillary acidic protein) Aim 2) Regional (occipital-parietal cortex, basal ganglia, and thalamus) brain MRI (T1/T2 and diffusion-weighted imaging) and magnetic resonance spectroscopy (MRS) biomarkers of neuronal injury (N-acetyl-aspartate) and energy failure (lactate) Aim 3 will model the combination of strong serum and imaging biomarkers of brain injury with clinical variables. We will assess serum biomarkers of brain mitochondrial injury with potential for novel therapeutic targets (cardiolipin and oxidized cardiolipin) in an exploratory aim. This proposed research is innovative, because a combined panel of serum and imaging biomarkers with clinical variables to accurately classify outcome after pediatric CA will be prospectively developed and optimized. These proposed aims leverage recent pilot successes and should generate accurate and reliable models of biomarkers that markedly improve post-resuscitation clinical care in children after CA. Furthermore, these results are expected to have a positive impact in advancing neurocritical care for these children, with forthcoming development of a serum biomarker point of care test and biomarker panels that will accurately classify risk of unfavorable outcome for clinicians and researchers needing to stratify by severity of injury, to monitor response to therapy, and ultimately to assist in their rehabilitation and recovery.
Patients in this arm will undergo trapeziectomy with suture tape suspension of the 1st metacarpal to the 2nd metacarpal via Arthrex InternalBrace device. This is the experimental group.