anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A whiplash injury can alter neck muscle function, which remains years after the injury and may explain why symptoms such as persistent pain and disability occur. There is currently limited knowledge about dynamic neck muscle function in chronic whiplash-associated disorders (WAD), and about the extent to which altered muscle function can improve after rehabilitation. Ultrasound can detect mechanical neck muscle function by measuring real-time deformation and deformation rate in the muscles. This method was used for five dorsal neck muscles in participants with chronic WAD versus matched controls in resistant neck rotation. We obtained real-time, non-invasive ultrasound measurements using speckle tracking, multivariate analyses, and mixed-design ANOVA analyses. The results showed altered deformation in the three deepest neck muscle layers, with less deformation area in the WAD group compared to controls in rotation to the most painful side at baseline. Participants in the WAD group performed three months of neck-specific exercises, resulting in improved deformation in the deep neck muscles in WAD and with a similar deformation pattern to controls, and the significant group differences ceased. We reveal new and important insights into the capability of ultrasound to diagnose altered neck muscle function and evaluate an exercise intervention.
INTRODUCTION: Multiplex polymerase chain reaction (PCR) and next-generation sequencing (NGS) can both be used to identify a neoplastic clonotype by targeting CDR3 and assessing rearrangements in IgH, IgK, IgL, TCR-β, and TCR-gamma loci. The clonotypic sequence can be robustly used to track minimal residual disease (MRD). The ability to track MRD by NGS in mixed phenotype acute leukemia (MPAL) is unknown and warrants investigation.
METHODS: Institutional Review Board (IRB) approval was obtained. Central Moffitt Cancer Center (MCC) database was searched to locate any patients with MPAL from over 600,000 entries. Patient charts were manually curated to identify those with clonoSEQ data, and clinical data was procured from the electronic medical record (EMR).
RESULTS: Twenty-nine patients with MPAL were identified. Only 2 patients with clonoSEQ testing were found. Both demonstrated a B/myeloid phenotype, and both were bilineal. NGS (clonoSEQ) identified 4 dominant (IGH) (patient A; 8/2019) and 2 dominant sequences (patient B; 10/2019), respectively. In both patients, clonoSEQ testing successfully tracked minimal residual disease and mirrored clinical disease burden.
CONCLUSIONS: This report is the first to confirm the utility of NGS-based MRD tracking in patients with MPAL and shows increased sensitivity of NGS over MRD flow cytometry.
A pain relief composition and method of preparing such for producing a therapeutic composition for topical application to the skin to provide symptomatic pain relief from a number of conditions such as arthritis. The pain relief composition is prepared from roots of the family of Burdock plants and in particular from at least one of the species Arctium lappa as Arctium minus in combination with roots of the Phytolacca family and in particular the species Phytolacca americana. The combination of roots are inserted into a receptacle containing water. The initial mixture is heated until boiling occurs and the mixture is continually boiled for a predetermined time interval until a coloration change of the substantially transparent water is seen to occur. There is formed a substantially darkened gray colored suspension which has found to include an extract of the combination of the Phytolacca and Burdock roots with some remaining extraneous bulk material. The suspension is cooled by exposing it to the atmosphere until room temperature is achieved. A predetermined quantity of isopropyl alcohol is stirred or otherwise mixed into the aqueous suspension subsequent to the bulk material being removed therefrom. The resulting pain relief composition is then available for external application to the skin of a user.
PURPOSE:The titled remedy, containing a substituted indoline as an active constituent, capable of exhibiting a high antimicrobial activity against fungi without irritation with low toxicity, and effective for treating superficial mycosis, e.g. trichophytosis, etc. CONSTITUTION:A remedy for superficial mycosis containing a substituted indoline of formulaI(R is H, halogen or nitro) as an active constituent. In formulating the remedy, one or more compounds of the active constituent in the form of fine powder may be applied to the affected part, and usually dissolved or dispersed in a liquid carrier, e.g. an alcohol such as methyl alcohol or ethyl alcohol, to give an alcoholic agent or lotion or incorporated with a solid carrier, e.g. vaseline or white ointment or a hydrophobic oily base, e.g. the silicone type, to give an ointment for application. The active constituent of the above-mentioned formula is synthesized by reacting a substituted indoline compound of  formula II with 2-chloroacetyl chloride in the presence of an organic solvent  and a base.
Graft-versus-host disease (GVHD) is a serious complication after bone marrow transplantation from another donor. GVHD is caused by certain cells called lymphocytes. Normally these cells make immune reactions that help protect the body from foreign substances that cause infection. Here, these cells attack the normal tissues of the body as if they were foreign substances. This interferes with the normal function of vital organs and results in their damage. In GVHD these cells attack the skin, liver and bowel. GVHD also increases the chances of infection.

VELCADE® is a drug that inhibits certain immune reactions that happen when lymphocytes encounter foreign substances. We are doing this research to determine if VELCADE® may be useful in treating GVHD.

VELCADE® is approved by the Food and Drug Administration (FDA) for the treatment of multiple myeloma in patients who have received at least two prior therapies and have demonstrated disease progression on their last therapy. Its effectiveness is also being tested in other cancers. The dose of the drug being used in this research study is the same as what is used for the treatment of multiple myeloma. It has not been approved by the FDA for use in GVHD. Therefore, using VELCADE® for GVHD is experimental in this research study.
PURPOSE:To extract and collect the titled substance from the resultant microbial cell, by cultivating a microorganism, belonging to the genus Escherichia, and free from the controlling mechanism of the glutathione synthetase. CONSTITUTION:A microorganism belonging to the genus Escherichia, having the gamma-glutamylcrsteine synthetase activity and glutathione synthetase activity, and free from the inhibition against the gamma-glutamylcysteine synthetase activity by glutathione, e.g. Escherichia coli, is cultivated in a culture medium containing a carbon source, nitrogen source, inorganic salt, etc. under aerobic conditions to give the aimed cultivated microbial cell. After the completion of the cultivation, the microbial cell is extracted with water under heating, and the resultant extract is then treated with by the well-known method, e.g. the treatment with an ion exchange resin.
Inhibiting the expression of spindle appendix cooled coil protein 1 (SPDL1) can slow down disease progression and is related to poor prognosis in patients with esophageal cancer. However, the specific roles and molecular mechanisms of SPDL1 in esophageal squamous cell carcinoma (ESCC) have not been explored yet. The current study aimed to investigate the expression levels of SPDL1 in ESCC via transcriptome analysis using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. Moreover, the biological roles, molecular mechanisms, and protein networks involved in SPDL1 were identified using machine learning and bioinformatics. The cell counting kit-8 assay, EdU staining, and transwell assay were used to investigate the effects of inhibiting SPDL1 expression on ESCC cell proliferation, migration, and invasion. Finally, the correlation between the SPDL1 expression and cancer immune infiltrating cells was evaluated by analyzing data from the TCGA database. Results showed that SPDL1 was overexpressed in the ESCC tissues. The SPDL1 expression was related to age in patients with ESCC. The SPDL1 co-expressed genes included those involved in cell division, cell cycle, DNA repair and replication, cell aging, and other processes. The high-risk scores of SPDL1-related long non-coding RNAs were significantly correlated with overall survival and cancer progression in patients with ESCC (P < 0.05). Inhibiting the SPDL1 expression was effective in suppressing the proliferation, migration, and invasion of ESCC TE-1 cells (P < 0.05). The overexpression of SPDL1 was positively correlated with the levels of Th2 and T-helper cells, and was negatively correlated with the levels of plasmacytoid dendritic cells and mast cells. In conclusion, SPDL1 was overexpressed in ESCC and was associated with immune cells. Further, inhibiting the SPDL1 expression could effectively slow down cancer cell growth and migration. SPDL1 is a promising biomarker for treating patients with ESCC.
Immediately before surgery, contact point composite stops were placed to prevent the collapse of the suspended sutures in the inter-proximal spaces.• The entire gingival papillary complex will be moved coronally using a vertical mattress suture anchored in the lingual gingiva. The anchorage in the lingual gingiva will be placed far apically. The suture must capture the buccal flap and graft to avail optimal stabilization (Aroca et al., 2010, 2013; Azzi et al, 2002).
PURPOSE: Retentional pigment epithelial detachment (PED) associated with age-related scattered hypofluorescent spots on late-phase indocyanine green angiography (ASHS-LIA) is hypothesized to be caused by Bruch membrane's lipid barrier. This study aimed to report the natural course of retentional PED and evaluate the relationship between retentional PED evolution and ASHS-LIA.
METHODS: Patients with treatment-naïve retentional PED were enrolled and observed every 3 months for at least 12 months. Treatment was not performed except for secondary macular neovascularization.
RESULTS: In 55 studied eyes with a median follow-up of 18.0 (range: 12-36) months, 87.3% (48/55) of the retentional PEDs persisted, 7.3% (4/55) resolved, and 5.5% (3/55) progressed to polypoidal choroidal vasculopathy. The mean PED area significantly increased during the follow-up ( P < 0.001) and with the ASHS-LIA grade at each follow-up point (all P <0.05), especially during the first 6 months before approaching the edge of confluent ASHS-LIA. Persistent PEDs were mostly stable (52.1%) or enlarged (45.8%) but reduced in only 1 case (2.1%) because of retinal pigment epithelium microrip at the edge of PED. The persistent PEDs were all within the ASHS-LIA region, especially the macular confluence region. The resolved PEDs all had grade 1 ASHS-LIA and resolved after gradual expansion of PED beyond the confluent ASHS-LIA region. Pigment epithelial detachments that progressed to macular neovascularization all had confluent grade 2 or 3 ASHS-LIA. Retinal pigment epithelium microrips or apertures within PED did not affect the progression of the PED.
CONCLUSION: The natural course of retentional PED is closely related to the features of ASHS-LIA and supports its lipid-barrier hypothesis.
FIELD: biotechnology, veterinary microbiology. SUBSTANCE: vaccine has high-immunogenic strain of Chlamydia psittaci K-8-K VIEV at titer 10 8,5-9,0 ELD 50 /0.2 ml taken at effective amount. Vaccine can contain light mineral oil and anhydrous lanolin as adjuvant at ratio = (87:13)-(90:10), or aerosil and saponine and formalin as an inactivating agent. Used strain is adapted to culturing in transplanted cell line of saiga kidney. Strain can be accumulated at higher titers as compared with that at culturing in chicken embryos. Obtained antigen does not contain inert proteins and does not require the additional purification and concentrating. EFFECT: enhanced effectiveness of vaccine. 3 cl
Participants in the dual-task training group will also participate in a 12-session program conducted 60 minutes per session, 3 days a week, for a total of 4 weeks. They will perform a cognitive task or motor task concurrently with the balance/gait task. The framework of progressive balance exercises in the dual-task training group will be progressed from simple to more complex tasks as outlined for the single-task training group. In addition, a variety of added tasks will be progressively integrated into the dual-task balance training program.
Patients in the FOLFOXIRI + Bmab group receive until 12 cycles of FOLFOXIRI plus bevacizumab, consisting of a 30-minute infusion of bevacizumab at a dose of 5 mg per kilogram, a 60-minute infusion of irinotecan at a dose of 150 mg per square meter, and a 120-minute infusion of oxaliplatin at a dose of 85 mg per square meter and a concomitant 120-minute infusion of leucovorin at a dose of 200 mg per square meter, followed by a 48-hour continuous infusion of fluorouracil to a total dose of 2400 mg per square meter. Cycles were repeated every 14 days. After 13 cycles, patients receive fluorouracil, leucovorin and bevacizumab every 14 days until disease progression.
OBJECTIVE: Children with congenital anorectal malformation (CAM) experience challenges with defecation. This study aims to assess defecation in preschool-age children with CAM and to evaluate the correlation between pelvic floor muscle developed assessed by magnetic resonance imaging (MRI) and postoperative defecation.
METHODS: We collected clinical data and MRI results from 89 male children with CAM. The bowel function scores for children with Perineal (cutaneous) fistula, Rectourethral fistula(Prostatic or Bulbar), and Rectovesical fistula were computed. MRI scans were subjected to image analysis of the striated muscle complex (SMC). The association between pelvic floor muscle score and bowel function score was examined using the Cochran-Armitage Trend Test.
RESULTS: We observed that 77.4% of the SMC scores by MRI for Perineal fistula were good. The Rectourethral fistula SMC score was 40.6% for moderate and 59.4% for poor. The SMC score for Rectovesical fistula was 100% for moderate. Furthermore, 77.4% of patients with Perineal fistula had bowel function scores (BFS) ≥ 17 points. Among those with Rectourethral fistula and Rectovesical fistula, 12.5% and 0 had BFS ≥ 17 points, respectively. An analysis of muscle development and bowel function in patients with Rectovesical fistula, Rectourethral fistula, and Perineal fistula revealed a correlation between SMC development and BFS. Subgroup analysis showed that the Perineal fistula had statistical significance; however, the Rectourethral fistula and Rectovesical fistula were not statistically significant.
CONCLUSION: A correlation exists between pelvic floor muscle development and postoperative defecation in children with Perineal fistula.
Malignant brain tumors are defined as any World Health Organization grade III-IV glioma and any solid tumor metastasis (spread) to the brain. Recurrent malignant brain tumors (RMBTs) are defined as either: 1) malignant tumors, originating in the brain, that have recurred at least once or 2) malignant tumors originating elsewhere in the body that have spread to the brain at least once. They share an increasing incidence, clinical and radiographic characteristics, lack of effective therapies, tendency to recur, and poor outcome. Importantly, recurrent malignant brain tumor's shared characteristics may be usefully exploited by an emerging class of biologic agents called metabolic modulators of which Dichloroacetate (DCA) is the drug in the class most thoroughly investigated clinically. DCA's mechanism of action and tolerability have been extensively demonstrated in the treatment of chronic metabolic disorders. Furthermore, the preciseness of DCA's mechanism of action appears to target abnormal tumor cell metabolism.
Patients swallowed the capsules in left lateral position, leaning on their left forearms and elbows, while we were positioning the magnet tightly against their backs. With the magnetic field vector X,Y,Z axis 180, -90 and 90, respectively. After swallowing the capsules with a small amount of water, they remained in this left lateral decubitus position.
Disclosed herein are compositions and methods for treating diseases such as cancer. The compositions comprise one or more polysaccharides in an admixture with one or more therapeutic agents. This admixture can be administered to a subject in need thereof using any known method of administration. The therapeutic agent, if administered alone, can cause undesirable side-effects in the subject. The polysaccharide component minimizes or eliminates these side effects. The compositions described herein effectuate an enhanced therapeutic effect along with reduced toxicity.
BACKGROUND: Obesity is a global epidemic and a major contributor to chronic kidney disease worldwide. This interventional study aimed to evaluate the effects of a unique parsley seed bread and a healthy balanced diet on serum osteopontin level and renal function in obese women.
METHODS: A total of 85 obese women (BMI, 35.68 ± 0.47 kg/m2) participated in an 8-week nutritional intervention comprising two phases. In the first phase, participants consumed 100 g of ground parsley seed bread along with a healthy balanced low caloric regimen for four weeks. In the second phase, Baladi bread was substituted for the supplement, providing an equal caloric intake, for another four weeks. Relevant Anthropometric measurements, blood pressure, dietary recall, and biochemical parameters (osteopontin, IL-1β, IL-10, kidney functions, and lipid parameters) were assessed before and after each intervention phase.
RESULTS: Following the initial intervention phase, there were significant improvements in all recorded mean anthropometric parameters (p ≤ 0.001). Lipid parameters and risk factors also significantly decreased (p < 0.05), while osteopontin, creatinine, and IL-1β levels decreased significantly. eGFR, creatinine clearance, IL-10 increased. However, these improved values returned to elevated levels after the omission of the supplement in the second phase. There was a significant negative correlation between osteopontin and creatinine, creatinine clearance, and IL-10.
CONCLUSION: The combined effect of the novel parsley seed-based intervention and a healthy balanced low-calorie regimen demonstrated improvements in osteopontin level associated with renal disorders, and inflammation, in addition to dyslipidemia in obese women. This suggests a promising approach for improving and protecting kidney disorders.
1. If the woman has not adhered to the prescribed regimen (NuvaRing has been out of the vagina for more than three hours or the preceding ring-free interval was extended beyond one week), consider the possibility of pregnancy at the time of the first missed period and discontinue NuvaRing use if pregnancy is confirmed.
  2. If the woman has adhered to the prescribed regimen and misses two consecutive periods, rule out pregnancy.
  3. If the woman has retained one NuvaRing for longer than four weeks, rule out pregnancy.
The present invention provides a mouth health care toothpaste composition. The present invention is to solve a problem of a conventional toothpaste composition. So, the mouth health care toothpaste does not include paraben and a chemical detergent in the toothpaste composition. The mouth health care toothpaste composition contains the skullcap extract which is a natural plant preservative and substitutes the paraben which is the preservative. Also, the mouth health care toothpaste composition also does not include a vegetable detergent and contains moringa extract performing a gingivitis prevention action, an antibacterial action, an anti-inflammatory action, and antivirus action. The mouth health care toothpaste composition also contains a Lindera glauca extract effective to anti-inflammatory treatment, infection release, and infection treatment by containing a large quantity of polyphenol and also contains Myrrha which is widely used for sterilization action, pain treatment, stomatitis treatment, and gum treatment. The mouth health care toothpaste composition also contains frankincense effective to improve an immunity level, injury recovery, and infection recovery and contains an NOS (sulfur) extract helpful to treatment and reinforcement of cartilage in the mouth. The mouth health care toothpaste composition contains an edible silver leaf (fine silver particle powder in the particle diameter of 20-150 μm: bacteria suppression effect) and, therefore, blocks harmful ingredients of the toothpaste composition in the mouth after brushing the mouth. So, the mouth health care toothpaste composition can protect and increase beneficial bacteria (oral probiotics) in the mouth and the body and eliminates the bacteria such as Helicobacter pylori which is a cause of an ulcer and bad breath by generating hydrogen peroxide. Therefore, the mouth health care toothpaste composition can improve defective power in the mouth and removes dental plaque. Moreover, the mouth health care toothpaste composition can reinforce oral skin and oral cartilage.
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
Patients who have an HLA antigen in common with COVID-19 fighting T cells will receive the COVID-19 T cells. They will be premedicated with diphenhydramine and acetaminophen before the cells are infused intravenously. Close monitoring will continue in the patients' homes for 14 days. Three to six patients will receive a specific dose of T cells, and then if there are no serious side effects, the dose will be increased for the next group of patients. There are 4 doses of T cells to be tested, and each patient will complete a 14 day monitoring period before the next patient can be treated.
FIELD: medicine, pharmaceutics. SUBSTANCE: the method suggested contains, g/100 ml: acyclovir as an active substance 0.1-20.0 and cellulose derivative as additional substances 0.1-15.0, mono- or disaccharide or the mixture of mentioned sugars 112.0-65.0, alcohol 0.5-45.0, water - up to 100 ml and conservant 0-3.0, not obligatory. The composition may additionally contain aromatizer at 0.1- 5.0 g/100 ml composition. The novel pharmaceutical composition is obtained by applying usual methods in the form of suspension. The composition in question meets the requirements for pharmaceutical preparations being stable at storage period. EFFECT: higher antiviral efficiency and stability at storage period. 6 cl, 1 tbl, 4 ex