anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sample of patient died with different types of myocarditis without Covid-19 disease. These samples are used as control and are part of database of previously collected samples of CVPath Institute Inc.
The purpose of this research study is to evaluate a blood test to measure circulating tumor DNA (ctDNA). It is hypothesized that ctDNA may identify patients who can be considered for additional therapy. 40 People with non-metastatic non-small cell lung cancer will be asked to take part in this study. Participants will have approximately 3 teaspoons of blood withdrawn from a vein at three different times. These times will be before primary treatment (either surgery or radiation therapy), 1 month after primary treatment, and 4 months after primary treatment. The total amount of blood withdrawn during the study will be approximately 9 teaspoons. Participants will be followed every 3 months for 12 months to determine if a confirmed recurrence or progression has occurred. Participants will also be asked to complete questionnaires on their quality of life and their smoking behaviors. As part of this study, a blood sample will be obtained and DNA from participants blood sample will be purified. DNA, or deoxyribonucleic acid, stores and transmits inherited traits, such as eye color or blood type. As part of this research project, participant's DNA will be studied in an effort to find out if there are genes that contribute to medical conditions like their cancer that are part of the study. If participants have surgery to have tumor removed or if participants have a biopsy of their tumor, the study would like to take some of the leftover tissue to purify and study the DNA from the tissue sample.
A method for classifying human blastocysts includes obtaining images of a set of artificially fertilized (AF) embryos incubating in an incubator. A morphological quality of the AF embryos is determined based on a classification of the images by a convolutional neural network trained using images of pre-classified embryos. Each of the AF embryos is graded based on the morphological quality. A probability that a given graded AF embryo will result in a successful pregnancy after the given AF embryo is implanted in a gestating female is computed for each of the AF embryos from the set based on a grade of the given AF embryo and clinical parameters associated with the gestating female. One or more graded AF embryos to be recommended to be implanted in the gestating female from the set are selected based on the probability of successful pregnancy. An identity of each of the selected graded AF embryos and a number of the selected graded AF embryos to be potentially implanted in the gestating female is then output based on an outcome desired by the gestating female following implantation.
Patients in the ASSIP Group will receive 3-4 sessions of the Attempted Suicide Short Intervention Program (ASSIP) which is a specific therapy for patients with a suicide attempt in their personal history. Each ASSIP session takes approximately 50 minutes.
Gut microbiota in ICU patients is sorely distorted, there is an important loss of diversity which can be traduced by a decrease of commensal bacteria and an increase of pathogens. The virulence, infectivity, and transmissibility of the emerging SARS-Coronavirus 2 is a reason for us to find strategies and therapeutics to curb the epidemic. Gut mucosa is very probably a target for the virus and it seems likely that feces are a way of transmissibility. It suppose too that gut microbiota is more weathered in patients with a SARS-CoV-2 infection, moreover if they have to be hospitalized in ICU. For this reason, the present study would like to collect oral and rectal swab from patients hospitalized in ICU for a serious SARS-CoV-2 infection and from patients hospitalized in ICU for another reason that a SARS-CoV-2 infection at day 1, each 7 days and at the end of their ICU stay. Other objectives are to know if this distorted microbiota is a risk factor for poor outcomes in our ICU patients, if antibiotics and artificial nutrition are too a risk factor of weathered microbiota and finally if we can connect oral and rectal dysbiosis to use the oral dysbiosis to predict the rectal dysbiosis in view of the ease to collect oral sample.
The invention relates to the field of medicines, in particular to application of meptazinol. Experiments show that the meptazinol can achieve the antidepressant effect by increasing the Ahi1 level. The experiment utilizes chronic stress to construct a depression model mouse, changes of Ahi1 protein are observed, and the result shows that: after giving the mice a continuous spatial behavioral restriction for 21 days, the mice were tested for depression-like behavioral changes using tail-overhang experiments and forced swimming experiments. After the molding was successful, the mice were intraperitoneally injected at a dose of 10mg/kg, and the control group was given physiological saline (NS) while continuing to perform spatial behavior restriction every day for two consecutive weeks at 12 am. Depression-like behavioral changes in mice were detected using tail-overhang and forced swimming experiments. Then, the protein level of hippocampal Ahi1 of the depressed model mouse is obviously reduced compared with that of a dosing group by using a Western Blot method for detection.
The present invention relates to a conjugate having colloidal stability in a medium comprising a metallic nanoparticle coated with a non-activating peptide which is ordered on the nanoparticle surface. It also relates to a pharmaceutical composition and to a process for the preparation thereof. The conjugates of the invention are used for the activation of the immune system, in particular the innate immune system, as well as for the modulation of immune responses, production of antibodies and detection of substances via antigen-antibody interactions. Inventors have found that non-activating peptides which, in themselves, do not trigger any activation of the immune system, even when they are in an aggregated state, are capable to activate the immune system, in particular the innate immune system, when ordered onto the surface of a metallic nanoparticle. These conjugates are able to achieve activation of the innate immune system, in particular the innate immune system despite their small size. Thus, the use of the conjugates of the invention offers the possibility to render molecules, otherwise undetectable, visible to the immune system.
Participants will receive NVA237 once daily in addition to their background therapy during the 52- week treatment period. All participants will receive salbutamol/ albuterol as rescue medication.
PURPOSE:To provide a cosmetic which is gelatinous before application to the skin and is softened in the case of application and having excellent spreadability and handleability, by using a substrate composed of a single phase domain liquid crystal structure derived from a hydrophilic nonionic surfactant, a water- soluble substance having OH group, an oil component and water. CONSTITUTION:The objective cosmetic contains a substrate consisting of a single phase domain liquid crystal structure derived from 10-20(wt)% hydrophilic nonionic surfactant (having an HLB of >=10, e.g. polyoxyethylene sorbitan fatty acid ester), 5-15% water-soluble substance having OH group in the molecule (preferably glycerol, ethanol, etc.), 30-80% oil component (preferably fluid paraffin, etc.) and 5-30% water. Since the cosmetic is gelatinous and easily handleable and is softened and liquefied when applied to the skin, it gives excellent feeling to the skin (e.g. spreadability, smoothness, etc.) and has high impregnation property to the skin. When water is added to the cosmetic, the oil component is converted to an O/W-type emulsion particle which can be removed easily from the skin.
The present disclosure provides systems and methods that leverage machine-learned models in conjunction with user-associated data and disease prevalence mapping to predict disease infections with improved user privacy. In one example, a computer-implemented method can include obtaining, by a user computing device associated with a user, a machine-learned prediction model configured to predict a probability that the user may be infected with a disease based at least in part on user-associated data associated with the user. The method can further include receiving, by the user computing device, the user-associated data associated with the user. The method can further include providing, by the user computing device, the user-associated data as input to the machine-learned prediction model, the machine-learned prediction model being implemented on the user computing device. The method can further include receiving, by the user computing device, a current disease prediction for the user as an output of the machine-learned prediction model. The method can further include providing, by the user computing device, data indicative of the current disease prediction for the user to a central computing system for use in updating a prevalence map that models prevalence of the disease over a plurality of geographic locations.
<P>PROBLEM TO BE SOLVED: To provide an external preparation for the skin which includes tranexamic acid dissolved stably in high concentration, exhibits high penetration of tranexamic acid into the stratum corneum even with a practically small amount of application, although externally applied tranexamic acid normally penetrates little into the stratum corneum and has lasting penetration of tranexamic acid into the stratum corneum by controlling the re-crystalization of tranexamic acid on the surface of the skin after application.  <P>SOLUTION: The external preparation for the skin is of an emulsion type and includes an aqueous phase containing tranexamic acid or its salt, an oil phase and a surfactant. The oil phase contains a higher fatty acid. The surfactant used is one kind or not less than two kinds selected from among phosphate-based anionic surfactants and/or nonionic surfactants having an HLB of 6.0-18.0. The tranexamic acid or its salt is dissolved in the aqueous phase having an adjusted pH of 4.0-6.0 in an amount of 5.0-12.0 mass% to the total amount of the external preparation for the skin.  <P>COPYRIGHT: (C)2011,JPO&INPIT
PURPOSE: A composition and a health functional food containing a Gleditsiae Semen extract are provided to suppress the growth of renal cancer cells and to effectively treat renal cancer. CONSTITUTION: A composition for treating renal cancer contains an organic solvent extract of Gleditsiae Semen as an active ingredient. The organic solvent is ethanol. The extract is prepared by extracting at 50 deg. C. for 24 hours, and dried and concentrated at 45 deg. C. The composition further contains a pharmaceutically acceptable carrier or diluents. [Reference numerals] (AA) Relative cellular viability
Cation chloride cotransporters (CCC) play a critical role in neuronal chloride homeostasis. Altered CCC expression and function has emerged as a hallmark of wide range of psychiatric and neurological conditions, including various forms of epilepsy. Elevated intraneuronal chloride concentration is thought to result in depolarizing GABA signaling that may contribute to pathological activities and seizures. Compensating for the dysregulation of CCC function in the pathology therefore appears as a promising therapeutic strategy. Bumetanide, an antagonist of the Na/K/Cl co-transporter NKCC1 failed to prevent acute neonatal seizures in the NEMO trial. Here, instead, the inventors tested the effects of novel candidate KCC2 enhancers on epileptiform activity  in vitro  and  in vivo . The inventors show that FDA-approved prochlorperazine (PCPZ) as well as CLP257 potentiate KCC2 function by promoting its membrane clustering, through a mechanism/pathway that does not involve phosphorylation of canonical residues. Both PCPZ and CLP257 reduce interictal activity recorded  in vitro  in epileptogenic postoperative brain samples from mesial temporal lobe epilepsy patients. In addition, chronic PCPZ administration strongly reduces seizure occurrence in a mouse model of temporal lobe epilepsy. Their results demonstrate for the first time the antiepileptic potential of a KCC2 enhancer and suggest PCPZ may be used in adjunctive therapy in pharmaco-resistant epilepsy.
For this single case research design with alternating treatments without baseline, 5 participants with severe speech and physical impairment will complete copy spelling tasks with 3 signal adaptive modeling configurations. Outcome measures are typing accuracy, typing speed and user experience.
A system for arranging transport of adapted nutrimental artifacts with user-defined requirements is disclosed. The system includes a computing device configured to receive a restricted nutrimental datum and at least one food condition. Computing device transmits the at least a first filter set to a user-client device. Computing device retrieves a sustenance provider datum and a physical performer instruction set. Computing device generates a sustenance provider instruction set and a physical performer instruction set. Computing device selects the at least a sustenance provider and the at least a physical performer. Computing device transmits the selection of the at least a sustenance provider and the selection of the at least a physical performer to the at least a user-client device.
The invention discloses a preparation method for ginkgo oil powder which is made from the extractive of ginkgo or ginkgo leaf by the microcapsule technology. The ginkgo or the ginkgo leaf is extracted in organic solvent, and is leached and separated by supercritical carbon dioxide or the traditional squeezing method. Then the extractive is made into water emulsion together with the emulsifier and the embedding medium, ensuring that the extractive is embedded by the embedding medium. And then the ginkgo oil powder is produced after the drying process. In the invention, the microcapsule embedding technology is utilized to produce the ginkgo oil powder, thereby improving the shelf life of the ginkgo oil powder and causing the possibility of the extensive popularization and application. The ginkgo oil powder of the invention not only can be used widely as the raw material of health food in the nutrition food and the health food, but can be used in the field of cosmetics, medicine and excipient.
PURPOSE:To obtain a drug for alleviating and eliminating pain and sting caused by malignant tumor and low side effects, containing a plant of Rabdosia trichocarpa or an extract thereof. CONSTITUTION:A plant material of Rabdosia trichocarpa, a perennial weed naturally growing in fields and mountains, is dried, cut, ground or pulverized and used as a medicinal component. The extract is dried, ground and extracted with hot water, etc. The plant material or the extract is mixed with ordinarily used drug additives and pharmaceutically manufactured by a conventional procedure to give the aimed substance. The substance can be prepared into powder, capsule agent, tablet, etc. A dose is 1-10g, preferably 2-3g calculated as dried plant material per adult daily and orally administered dividedly twice - three times daily.
BACKGROUND: Heterozygous loss-of-function variants in CHD8 have been associated with a syndromic neurodevelopmental-disease spectrum, collectively referred to as CHD8-related neurodevelopmental disorders. Several different clinical manifestations, affecting neurodevelopmental and systemic domains, have been described, presenting with highly variable expressivity. Some expressions are well established and comprise autism spectrum disorders, psychomotor delay with cognitive impairment, postnatal overgrowth with macrocephaly, structural brain abnormalities, gastrointestinal disturbances, and behavioral and sleep-pattern problems. However, the complete phenotypic spectrum of CHD8-related disorders is still undefined. In 2021, our group described two singular female patients with CHD8-related neurodevelopmental disorder and striking dystonic manifestations, prompting the suggestion that dystonia should be considered a possible component of this condition.
CASE SERIES PRESENTATION: We describe three additional unrelated female individuals, each carrying a different CHD8 frameshift variant and whose clinical presentations were primarily characterized by young-onset dystonia. Their dystonic manifestations were remarkably heterogeneous and ranged from focal, exercise-dependent, apparently isolated forms to generalized permanent phenotypes accompanied by spasticity and tremor. Neurocognitive impairment and autistic behaviors, typical of CHD8-related disorders, were virtually absent or at the mild end of the spectrum.
CONCLUSIONS: This work validates our previous observation that dystonia is part of the phenotypic spectrum of CHD8-related neurodevelopmental disorders with potential female preponderance, raising new challenges and opportunities in the diagnosis and management of this condition. It also highlights the importance of in-depth neurologic phenotyping of patients carrying variants associated with neurodevelopmental disorders, as the connection between neurodevelopmental and movement disorders is proving closer than previously appreciated.
Exercise-induced muscle damage is common in athletes and recreational exercisers and can lead to muscle soreness, weakness, and impaired muscle function. The precise mechanisms are unclear but oxidative stress and inflammation are thought to play a role. (Poly)phenols are substances abundant in Vaccinium berries that have been suggested to possess antioxidant and anti-inflammatory effects that could help improve exercise performance and/or recovery from exercise. The objective of this systematic review was to evaluate the benefits of Vaccinium berry supplementation on exercise performance and recovery, as well as on exercise-induced oxidative and inflammatory biomarkers in healthy individuals. A comprehensive search was conducted in PubMed, ProQuest Medline, Web of Science, Cochrane Library, and Scopus. Studies were included if the participants were healthy individuals who were supplemented with any Vaccinium berry or Vaccinium berry-based products in comparison to a control group. Of the 13 articles included in this review, no significant differences in the exercise performance were found and only one study reported benefits for markers of recovery. Interleukins and c-reactive protein were the most frequently reported biomarkers, but there was limited evidence that Vaccinium berry supplementation impacted them post-exercise. Most studies were of high quality and showed a low risk of bias. Vaccinium berry supplementation is not effective in modulating markers of exercise-induced inflammation and oxidative distress in healthy individuals; nevertheless, more studies are required to evaluate their effects on exercise performance and recovery in this population.
Compositions and methods for dietary enhancement of immune system function. The compositions may include zinc(+2) and a zinc ionophore. The compositions may include zinc(+2), a first zinc ionophore and a second zinc ionophore different from the first zinc ionophore. The zinc ionophore may include quercetin. The zinc ionophore may include a quinine compound. The compositions may include one or more of l-lysine, vitamin C, vitamin D, vitamin E, curcumin and epigallocatechin gallate. The compositions may be manufactured as dietary supplements. The methods may include dosing quantities of components of the compositions. The dosing quantities have been recommended by multi-month clinical experience during the COVID-19 pandemic.
Preclinical models of osteochondral defects (OCDs) are fundamental test beds to evaluate treatment modalities before clinical translation. To increase the rigor and reproducibility of translational science for a robust "go or no-go," we evaluated disease progression and pain phenotypes within the whole joint for two OCD rat models with same defect size (1.5 x 0.8 mm) placed either in the trochlea or medial condyle of femur. Remarkably, we only found subtle transitory changes to gaits of rats with trochlear defect without any discernible effect to allodynia. At 8-weeks post-surgery, anatomical evaluations of joint showed early signs of osteoarthritis with EPIC-microCT. For the trochlear defect, cartilage attenuation was increased in trochlear, medial, and lateral compartments of the femur. For condylar defect, increased cartilage attenuation was isolated to the medial condyle of the femur. Further, the medial ossicle showed signs of deterioration as indicated with decreased bone mineral density and increased bone surface area to volume ratio. Thus, OCD in a weight-bearing region of the femur gave rise to more advanced osteoarthritis phenotype within a unilateral joint compartment. Subchondral bone remodeling was evident in both models without any indication of closure of the articular cartilage surface. We conclude that rat OCD, placed in the trochlear or condylar region of the femur, leads to differing severity of osteoarthritis progression. As found herein, repair of the defect with fibrous tissue and subchondral bone is insufficient to alleviate onset of osteoarthritis. Future therapies using rat OCD model should address joint osteoarthritis in addition to repair itself.
PURPOSE: Postoperative management following elective cranial surgery, particularly after biopsy procedures, varies significantly across neurosurgical centres. Routine postoperative head CT scans, traditionally performed to detect complications such as intracranial bleeding or cerebral oedema, lack substantial evidence supporting their necessity.
METHODS: This study is a retrospective cohort analysis conducted at a regional neurosurgical department of 236 patients who underwent brain biopsies between 2018 and 2022. Patient data, including demographics, surgical details, and postoperative outcomes, were collected and analysed. The outcomes investigated were the incidence and impact of postoperative CT scans on time to discharge, management changes, and the influence of preoperative anticoagulation.
RESULTS: Out of 236 patients, 205 (86.86%) underwent postoperative CT scans. There was no significant relationship between postoperative hematoma, as detected on a CT scan, and neurological deficit (p = 0.443), or between preoperative anticoagulation and postoperative bleeding on CT scans (p = 0.464). Patients who had postoperative CT scans had a significantly longer length of stay (LOS) compared to those who did not (p < 0.001). Intraoperative bleeding was a predictor of hematoma on postoperative CT (p = 0.017) but not of postoperative neurological deficit. The routine postoperative CT scan showed limited predictive value for symptomatic deficits, with a positive predictive value of 6.67% and a negative predictive value of 96.88%.
CONCLUSIONS: Routine postoperative CT scans after brain biopsies do not significantly impact management or improve patient outcomes but are associated with longer hospital stays. CT scans should be reserved for patients showing clinical signs of complications rather than used as a routine procedure after a brain biopsy.