anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1463550 Compositions containing a complex of chloramphenicol and a tetracycline G BODRERO 6 Aug 1974 34495/74 Heading A5B A therapeutically administerable composition comprises a complex of chloramphenicol and a tetracycline and a pharmaceutically acceptable carrier or diluent. The compositions may also contain vitamin B<12> and a local anaesthetic such as procaine hydrochloride. The composition may also contain a complexing agent for bivalent ions, e.g. sodium hexametaphosphate. The composition may be prepared by dissolving chloramphenicol and a tetracycline in an organic solvent; dissolving a complexing agent for bivalent ions in water; mixing the two solutions to form a precipitate of the antibiotic complex; dissolving vitamin B<12> and a local anaesthetic in water and adding the solution to the solution containing the precipitated antibiotic complex; and adjusting the pH to a value of from 4.5 to 5.5. The compositions may be administered orally, by injection or in the form of suppositories.
Patients receive relugolix PO QD and enzalutamide PO QD on days 1-28 of each cycle. Cycles repeat every 28 days for up to 18 months in the absence of disease progression or unacceptable toxicity. After 4 months of treatment with relugolix and enzalutamide, patients begin IGRT per standard of care. Patients also undergo fluorine F 18 piflufolastat PET/MRI and CT on the trial, undergo collection of blood samples throughout the trial, and undergo biopsy during follow up.
BACKGROUND: Recent reports have unveiled the potential utility of l-carnitine to alleviate metabolic dysfunction-associated steatohepatitis (MASH) by enhancing mitochondrial metabolic function. However, its efficacy at preventing the development of HCC has not been assessed fully.
METHODS: l-carnitine (2 g/d) was administered to 11 patients with MASH for 10 weeks, and blood liver function tests were performed. Five patients received a serial liver biopsy, and liver histology and hepatic gene expression were evaluated using this tissue. An atherogenic plus high-fat diet MASH mouse model received long-term l-carnitine administration, and liver histology and liver tumor development were evaluated.
RESULTS: Ten-week l-carnitine administration significantly improved serum alanine transaminase and aspartate transaminase levels along with a histological improvement in the NAFLD activity score, while steatosis and fibrosis were not improved. Gene expression profiling revealed a significant improvement in the inflammation and profibrotic gene signature as well as the recovery of lipid metabolism. Long-term l-carnitine administration to atherogenic plus high-fat diet MASH mice substantially improved liver histology (inflammation, steatosis, and fibrosis) and significantly reduced the incidence of liver tumors. l-carnitine directly reduced the expression of the MASH-associated and stress-induced transcriptional factor early growth response 1. Early growth response 1 activated the promoter activity of neural precursor cell expressed, developmentally downregulated protein 9 (NEDD9), an oncogenic protein. Thus, l-carnitine reduced the activation of the NEDD9, focal adhesion kinase 1, and AKT oncogenic signaling pathway.
CONCLUSIONS: Short-term l-carnitine administration ameliorated MASH through its anti-inflammatory effects. Long-term l-carnitine administration potentially improved the steatosis and fibrosis of MASH and may eventually reduce the risk of HCC.
Paragard can alter the bleeding pattern and result in heavier and longer menstrual cycles with intermenstrual spotting. 

In two clinical trials with Paragard, there were reports of oligomenorrhea and amenorrhea; however, a causal relationship between Paragard and these events could not be established. Menstrual changes were the most common medical reason for discontinuation of Paragard. Discontinuation rates for pain and bleeding combined were highest in the first year of use and diminished thereafter. The percentage of females who discontinued Paragard because of bleeding problems or pain during these studies ranged from 12% in the first year to 2% in Year 9. Females complaining of heavy vaginal bleeding should be evaluated and treated, and may need to discontinue Paragard [see Adverse Reactions (6.1)].
Stable viscous solutions for an sthetic purposes are obtained by dissolving in water an alkamine ester of a N-mono-alkylated or N-monoalkyloxyalkylated derivative of para- or ortho-aminobenzoic acid in the form of its salt with an hydroxy-acid of the aliphatic or aromatic series with addition of a prolamine (gliadine) and wheat mucilage.  The organic hydroxy acid salts of the bases are selected because the solubility of the hydrochlorides or sulphates is greatly diminished by the addition of the prolamine and mucilage.  Suitable acids mentioned are quinic, citric, tartaric, glycollic, lactic. According to examples : (1) the quinic acid salt of 4-butyl amino-benzoic acid-b -dimethylaminoethyl ester formed by treating the base with a solution of the acid in water is mixed with wheat mucilage, alcohol and an alcoholic solution of gliadine, and diluted ; acetone bisulphite is added and the solution filled into ampoules ; (2) the quinic acid salt of 4-b -methoxyethylaminobenzoic acid-b -diethylaminoethyl ester is treated in a similar manner to the preparation of Example (1).  Examples (3) and (4) : the citric acid salt of 2 - N - propylaminobenzoic acid - b  - diethylaminoethyl ester and the glycollic acid salt of 4 - propylaminobenzoic acid 1 - dimethylaminobutyl-3-ester are made up into preparations in a similar manner.  Specifications 241,767 and 260,605, [both in Class 2 (iii)], are referred to.ALSO:Stable viscous solutions for an sthetic purposes are obtained by dissolving in water an alkamine ester of a N-monoalkylated or N-monoalkyloxyalkylated derivative of para- or orthoaminobenzoic acid in the form of its salt with an hydroxy-acid of the aliphatic or aromatic series with addition of a prolamine (gliadine) and wheat mucilage.  The organic hydroxy acid salts of the bases are selected because the solubility of the hydrochlorides or sulphates is greatly diminished by the addition of the prolamine and mucilage.  Suitable acids mentioned are quinic, citric, tartaric glycollic, lactic.  According to examples 1.  The quinic acid salt of 4-butylaminobenzoic acid-b -dimethylaminoethyl ester formed by treating the base with a solution of the acid in water is mixed with wheat mucilage, alcohol and an alcoholic solution of gliadine, and diluted, acetone bisulphite is added and the solution filled into ampoules. 2. The quinic acid salt of 4-b -methoxyethylaminobenzoic acid - b  - diethylaminoethyl ester is treated in a similar manner to the preparation of Example 1. 3 and 4.  The citric acid salt of 2-N-propylaminobenzoic acid-b -diethylaminoethyl ester and the glycollic acid salt of 4-propylaminobenzoic acid 1-dimethylaminobutyl-3-ester are made up into preparations in a similar manner.  Specifications 241,767 and 260,605, [both in Class 2 (iii)], are referred to.
Patients who meet the criteria for enrollment initially receive four cycles of TCb (HP) \* neoadjuvant chemotherapy, followed by neoadjuvant radiotherapy starting from the fifth cycle of TCb (HP) \* neoadjuvant chemotherapy. After completion of six cycles of neoadjuvant chemotherapy, patients underwent breast magnetic resonance imaging. When a patient meets the MRI criteria suggestive of a complete clinical response (cCR), vacuum assisted core biopsy (VACB) targeting the primary lesion is performed under ultrasound or stereotactic guidance. A minimum of six cores, are obtained using a 7-10 G needle. Biopsy specimens are examined by a pathologist to assess the residual tumor and tumor bed. When no tumor or atypical cells are confirmed in the valid VACB specimen, breast and axillary surgery will be omitted.
PROBLEM TO BE SOLVED: To obtain a plaster matrix for nails capable of promoting the health through the nails and maintaining or improving the nails in healthy conditions by formulating a specific pharmacodynamically effective ingredient together with a tacky agent therein. SOLUTION: This plaster matrix for nails contains a tacky agent and a pharmacodynamically effective ingredient. For example, a cooling ingredient, a thermesthesic ingredient, an antimicrobial ingredient, a humectant ingredient and a keratin proliferation promoting ingredient can be cited as the pharmacodynamically effective ingredient. As for the pharmacodynamically effective ingredient, menthol, thymol, camphor, etc., are concretely preferred as the cooling ingredient. Glycerol, an extract from Guinea pepper and capsaicin, etc., are preferred as the thermestesic ingredient. Clotrimazole, miconazole nitrate, etc., are preferred as the antimicrobial ingredient and sodium hyaluronate, etc., are preferred as the humectant ingredient. An ecdysteroid, etc., are preferred as the keratin proliferation promoting ingredient.  The amount of the pharmacodynamically effective ingredient is 0.01-10 wt.% based on the total amount of the matrix. An acrylic tacky agent is preferred as the tacky agent and preferably formulated in an amount of 0.1-99 pts.wt.
The pharmaceutical preparation of the complex activity may be used in the medical facilities for treating the bone lesions and the hepatitis of different genesis. It may be used in complex treatment of cancer, leukemia in particular. The essence of the invention: The pharmaceutical preparation consists of glycine and low molecular weight polyvinyl pyrrolidon at a ratio of 49:1. Its manufacture consists in mixing and wetting the ingredients followed by drying and granulation. The aqueous solution of polyvinyl pyrrolidon is used for wetting. The advantage of this substance consists also in its detoxifying properties. The dosage form of the drug represents the pellets. The single dose of the drug in pellets is 4 g.
BACKGROUND: B lymphocytes play a key role in immunosuppression. This study investigated the prognostic value of B cell subsets in sepsis.
METHODS: Flow cytometry was used to assess peripheral B cell subsets from patients with sepsis on the first and seventh days following admission, as well as 111 healthy controls. The patients were divided into survivors and non-survivors, based on 28-day prognosis.
RESULTS: The analysis showed abnormal distribution and selective depletion of B cells and its subsets in the early stages of sepsis. On day 1, compared with survivors, non-survivors showed significant decreases in the proportion and absolute count of transitional (Tr) B cells, reductions in the proportion of CD5+ B cells, and increases in the proportion of double-negative (DN) B cells. On day 7, the proportions and absolute counts of Tr and CD5+ B cells significantly decreased whereas the proportion of DN B cells significantly increased in non-survivors. Ninety-four survivors and 15 non-survivors were included in our paired-sample rank-sum test. Compared to day 1, only the survivors showed significant increases in absolute B, Tr B, and CD5+ B cell counts by day 7. Multivariate Cox regression analysis showed that the proportion of DN B cells on day 1 (hazard ratio = 1.092 [95% confidence interval: 1.035-1.152], P = 0.001) was a risk factor for mortality, and Kaplan-Meier survival curve analysis showed that patients with proportions of DN B cells > 11.81% on day 1 had poorer prognoses. Receiver operating characteristic curve analysis showed that B cell subset parameters could predict mortality (area under the receiver operating characteristic curve [AUC], 0.741) and enhanced the prognostic value of the Acute Physiology and Chronic Health Evaluation II score (AUC, 0.840).
CONCLUSION: Our study revealed that deficiencies of B, Tr B, and CD5+ B cells, as well as a persistent increase in the proportion of DN B cells, were associated with poor prognosis-and that B cell subsets showed predictive value to mortality. These results provide new insights into the roles of B cell subsets in sepsis, as well as ways to better manage its progression and predict its course.
The content and delivery format of the developed GLB SCI lifestyle intervention program is subject to change based on guidance of the SCI Consumer Group. Therefore, this section provides a general description of the GLB AIM (lifestyle intervention program adapted for impaired mobility). The content of the GLB AIM core meetings include a mix of in-person (4) and telephone (9) sessions. The initial meeting is conducted in person, with one in-person sessions delivered each month, and the intervening weeks delivered by telephone. To achieve weight loss, participants will be encouraged to follow daily calorie and fat gram goals to achieve a .5 to 1 pound weight loss over the 13 weeks. Participants will also be encouraged to gradually increase their physical activity to ultimately achieve 150 weekly minutes.
Prior research suggests that social contact-based interventions are the most efficient way of reducing stigma. This study aims to address self-stigma and empower individuals who self-reported experiencing any kind of abuse during childhood and increase their openness to seeking help, if needed.

A total of 1000 adults with self-report experience of any kind of childhood abuse will be recruited to participate in a Randomized Controlled Trial (RCT) testing the efficacy of the intervention. Participants will be randomized into one of two arms: 1) A 2-minute video intervention in which a CM survivor (presented by either a female or male actor) shares their personal CM experience and describes how they were able to overcome feelings of shame and self-blame to seek mental health care; or 2) A 2-minute control video using the same actors, but without CM-related content. Both videos will be preceded by and immediately followed by questionnaires assessing self-stigma and openness to seeking treatment. An additional assessment of emotional engagement will be added immediately following intervention delivery. Following the intervention, there will be a 30-day follow-up to examine potential long-term effects.
As a common cause of shoulder pain, rotator cuff tears (RCTs) are difficult to treat clinically because of their unsatisfactory prognosis due to the fatty infiltration caused by muscle-derived stem cells (MDSCs). Previous studies have found that rapamycin (RAPA) can inhibit fatty infiltration. However, systemic administration of RAPA may cause complications such as infection and nausea, while local administration of RAPA may lead to the cytotoxicity of tendon cells, affecting the healing of rotator cuffs. In this study, biocompatible and clinically approved polycaprolactone-polyethylene glycol (PCL-PEG) is formulated into an injectable nanoparticle for the sustained release of RAPA. The results indicate that the RAPA/PCL-PEG nanoparticles (NPs) can efficiently prolong the release of RAPA and significantly reduce the cytotoxicity of tendon cells caused by RAPA. The study of the fatty infiltration model in rats with delayed rotator cuff repair shows that weekly intraarticular injection of RAPA/PCL-PEG NPs can more effectively reduce the fatty infiltration and muscle atrophy of rat rotator cuffs and leads to better mechanical properties and gait improvements than a daily intraarticular injection of RAPA. These findings imply that local injection of RAPA/PCL-PEG NPs in the shoulder joints can be a potential clinical option for RCTs patients with fatty infiltration.
Patients in group MA (mechanical alignment) will be operated according to mechanical implantation technique. In the mechanical group, femoral and tibial cutting blocks will be designed for a 0-degree angle according to the mechanical axis. Femoral rotation will be aligned with the femoral trans-epicondylar axis. Tibial rotation will follow femoral rotation.
Eye-hand coordination can be defined as the ability to perform activities that require the simultaneous use of eyes and hands. Eye-hand coordination supports our daily activities, interactions with objects and people, and is critical to understanding how the brain creates internal models of the space and generates movement within it (2). The eye-hand coordination represents the integration of visual information, perceptual stimuli and motor decisions in order to perform a specific task. Along with the development of technology, opportunities for stimulation of eye-hand coordination with the use of technical novelties have appeared. Virtual reality (VR) is a three-dimensional image, which is created by means of computer programs. It has become one of the technologies that offer many possibilities of application and use of its various aspects that can bring great benefits in the real world. In most educational communities VR has been used as an opportunity to support many students. VR allows the user to observe the world generated for their own needs as the real world and experience impressions that are not available in real life. It can be assumed that VR can help trainers or teachers, especially music teachers, by interacting through movement, realization and graphic images, to develop and shape skills such as eye to hand coordination. The use of virtual reality gives a wide range of possibilities for training, so it was decided to examine how it will affect the coordination of the eye-hand response in music school students.

The aim of the research was to evaluate the eye-hand coordination of music school students undergoing training sessions in the musical game "Beat Saber" conducted in immersive virtual reality.
Rocuronium bromide has not been studied for long-term use in the intensive care unit (ICU). As with other nondepolarizing neuromuscular blocking drugs, apparent tolerance to rocuronium bromide may develop during chronic administration in the ICU. While the mechanism for development of this resistance is not known, receptor up-regulation may be a contributing factor. It is strongly recommended that neuromuscular transmission be monitored continuously during administration and recovery with the help of a nerve stimulator. Additional doses of rocuronium bromide or any other neuromuscular blocking agent should not be given until there is a definite response (one twitch of the train-of-four) to nerve stimulation. Prolonged paralysis and/or skeletal muscle weakness may be noted during initial attempts to wean from the ventilator patients who have chronically received neuromuscular blocking drugs in the ICU. 

Myopathy after long-term administration of other nondepolarizing neuromuscular blocking agents in the ICU alone or in combination with corticosteroid therapy has been reported. Therefore, for patients receiving both neuromuscular blocking agents and corticosteroids, the period of use of the neuromuscular blocking agent should be limited as much as possible and only used in the setting where in the opinion of the prescribing physician, the specific advantages of the drug outweigh the risk.
The tooth will undergo low-intensity laser irradiation in continuous mode, employing a wavelength of 808 nm, a power output of 100 mW, a dose of 2 Joules, and a fluence of 35 J/cm\^2. The laser will be positioned perpendicular to the tooth surface, targeting the third cervical region of the vestibular surface (both mesial and distal aspects), as well as the center of the lesion, with an activation time of 2 Joules (equivalent to 20 seconds). As an adjunct to the laser therapy, a placebo varnish, devoid of the active ingredient (fluoride), will be utilized.The varnish will be applied with the assistance of a microbrush, ensuring coverage over the entire length of the lesion for 30 seconds. Following the interventions, patients will be advised to abstain from consuming hard foods and to postpone tooth brushing for at least four hours post-application of the varnish.
The present study explores the prevalence and socio-economic demographic factors affecting childhood illnesses. Diarrhoea, fever and ARI among under-five children in the North -East states of India using NFHS-5 data Kids file. Results showed that diarrhoea, ARI, and fever among the northeastern states were highest in Meghalaya.For diarrhoea Sikkim has the highest prevalence for children within 6 months while Meghalaya has the highest prevalence in the age groups 6- 12 months and 1- 2 years old children and Arunachal Pradesh has the highest rate in the age group 2- 5 years old children. Meghalaya stands out with the highest prevalence of fever and ARI in all age groups. Compared to Sikkim, the state of Meghalaya had more diarrhoea, ARI and fever, and it was statistically highly significant. However, Tripura and Assam had significantly higher odds of having fever and ARI than Sikkim. There is an association between diarrhoea, fever, and ARI and factors such as the age of the child and caregiver, the wealth status of the household, the quality of sanitation facilities, methods of stool disposal, and the caregiver's educational level.
The observed incidence of anti-drug antibodies is highly dependent on the sensitivity and specificity of the assay. Differences in assay methods preclude meaningful comparisons of the incidence of anti-drug antibodies in the studies described below with the incidence of anti-drug antibodies in other studies, including those of EBGLYSS or of other drug products. 

Antibodies to lebrikizumab-lbkz developed in 4/145 (2.8%) of subjects treated with EBGLYSS 250 mg every 2 weeks followed by 250 mg every four weeks during the 12-month treatment period in EBGLYSS studies. Most of these antibodies were neutralizing and of low titer. Similar results were observed in pediatric subjects who received EBGLYSS up to 12 months. The presence of anti-drug antibodies was not associated with changes to pharmacokinetics, efficacy, or safety of lebrikizumab-lbkz. The clinical relevance of these findings is unknown because of the low occurrence of ADA.
Composition for the treatment of skin disorders, preparation thereof and use thereof. It includes ketoconazole as the active principle. It is characterized in that as technological coadjuvant it includes triamcinolone acetonide and excipient. It advantageously includes 2% ketoconazole and 0.1% triamincinolone acetonide. It is presented in the form of a lotion for topical use, by the addition of a hydroalcoholic excipient which comprises 60% by volume of 96degree alcohol, 30% by volume of distilled water and 10% by volume of propylene glycol. The preparation of the composition is characterized in that it involves the dissolution, in a topaz glass bottle, of 96degree alcohol with ketoconazole and triamcinolone acetonide and dilution by means of distilled water, until the alcohol is 70degree, adding propylene glycol and placing in a water bath at a maximum temperature of 75degreeC. A lotion is obtained for the topical treatment of pityriasis, seborrhoeic dermatitis and psoriasis which does not exhibit side effects.
PROBLEM TO BE SOLVED: To economically obtain the subject compound useful as an α11 - adrenoreceptor antagonist useful for treating benign prostatic proliferation. SOLUTION: This compound of formula I [wherein, R is H, methyl of fluoro; L is a leaving group] [e.g. 3-(3-chloropropyl)-tosylthymine] is produced by reacting a compound of formula II with a compound of formula III under a basic condition, by reacting the product with a compound of formula IV under a basic condition to obtain a compound of formula V, following by the cleavage of a tosyl group of the compound of formula V in the presence of a cleavage agent (e.g. sodium methoxide). It is preferable that the above reaction is conducted in the presence of such a base as Et3 N, K2 CO3 , NaOH in such a solvent as CH3 CN/H2 O and H2 O at a temp. of about 15-25 deg.C.