anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Centrosome amplification is a feature of cancer cells associated with chromosome instability and invasiveness. Enhancing chromosome instability and subsequent cancer cell death via centrosome unclustering and multipolar divisions is an aimed-for therapeutic approach. Here, we show that centrosome amplification potentiates responses to conventional chemotherapy in addition to its effect on multipolar divisions and chromosome instability. We perform single-cell live imaging of chemotherapy responses in epithelial ovarian cancer cell lines and observe increased cell death when centrosome amplification is induced. By correlating cell fate with mitotic behaviors, we show that enhanced cell death can occur independently of chromosome instability. We identify that cells with centrosome amplification are primed for apoptosis. We show they are dependent on the apoptotic inhibitor BCL-XL and that this is not a consequence of mitotic stresses associated with centrosome amplification. Given the multiple mechanisms that promote chemotherapy responses in cells with centrosome amplification, we assess such a relationship in an epithelial ovarian cancer patient cohort. We show that high centrosome numbers associate with improved treatment responses and longer overall survival. Our work identifies apoptotic priming as a clinically relevant consequence of centrosome amplification, expanding our understanding of this pleiotropic cancer cell feature.
The present invention relates to acne, which is also known as comedo, a chronic inflammatory disease of hair follicle and sebaceous glands. The acne usually occurs on the face, back and other positions of young people, and is represented as comedones, papule, pustule, tubercle, cyst, and so on. The acne is essentially a chronic inflammatory disease of hair follicle and sebaceous glands. After the inflammatory papule is treated, concave scars and temporary pigmentation can easily occur to seriously influence the physiognomy. In particular, when the acne conglobata is not cured in a long period, the patients suffer from spiritual pains. And the present invention relates to a medicinal composition which is used for treating or preventing acne. The medicinal composition comprises Japanese honeysuckle, Angelica dahurica, radix scutellariae, honeysuckle, rhubarb, aloe and so on, and has significant effects on the treatment and prevention of the acne.
Warm-up exercises were performed by the participants on a cycle ergometer for a duration of 5-10 minutes. Group A was advised to start walking at a comfortable speed on a treadmill for the duration of 30-60 minutes; the intensity of the exercises was 55-75% of MHR, calculated by using a Karvonen method. Initially with the minimum intensity that was gradually raised up to the intensity of Targeted Heart Rate (THR). Once the THR is achieved the intensity was gradually decelerated and patient proceeded for the cool-down phase for 5-10 min.
Clinicians randomized to this arm receive guideline education + 10 pill dispense quantity defaults + alerts requiring justification of orders discordant with guidelines. Justifications are entered in the patient's medical record.
The invention relates to a fatigue-resisting immunity-enhancing healthcare wine and a method for preparing the same. The fatigue-resisting immunity-enhancing healthcare wine is prepared from the following raw materials: 6-8 parts by weight of antler, 10-12 parts by weight of stiff silkworm, 8-12 parts by weight of ginseng, 10-12 parts by weight of fructus rosae laevigatae, 7-8 parts by weight of epimedium, 4-6 parts by weight of radix angelicae, 15-18 parts by weight of Chinese wolfberry fruit, 5-6 parts of clove, 10-14 parts by weight of human placenta, 8-10 parts by weight of white paeony root, 5-6 parts of saururus chinensis, 6-8 parts by weight of fructus cnidii and 1,000 parts by weight of 38-degree white wine. The raw materials are all Chinese herbal medicines which are approved by the Ministry of Health of the People's Republic of China and used for preparing healthcare food. The fatigue-resisting immunity-enhancing healthcare wine is prepared according to the theory of traditional Chinese medicine and the scientific formula by selecting and fine processing the raw materials, is natural, nutritious and delicious and can provide a variety of healthcare nutrients needed by the human body. One people is suggested to drink the healthcare wine of 30-50ml every day or a proper amount. The healthcare wine can be drunken for a long time to take the effect of enhancing the immunity of human body, resisting fatigue and strengthening bones and muscles. The healthcare wine also has the efficacy of clearing and activating channels and collaterals, soothing nerves, tonifying qi, promoting metabolism and improving the activity of organs of the human body.
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of lisinopril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase of serum potassium. In hypertensive patients with normal renal function treated with Zestril alone for up to 24 weeks, the mean increase in serum potassium was approximately 0.1 mEq/L; however, approximately 15% of patients had increases greater than 0.5 mEq/L and approximately 6% had a decrease greater than 0.5 mEq/L. In the same study, patients treated with Zestril and hydrochlorothiazide for up to 24 weeks had a mean decrease in serum potassium of 0.1 mEq/L; approximately 4% of patients had increases greater than 0.5 mEq/L and approximately 12% had a decrease greater than 0.5 mEq/L [see Clinical Studies (14.1)]. Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity.

ACE is identical to kininase, an enzyme that degrades bradykinin. Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of Zestril remains to be elucidated.

While the mechanism through which Zestril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, Zestril is antihypertensive even in patients with low-renin hypertension. Although Zestril was antihypertensive in all races studied, Black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to monotherapy than non Black patients.

Concomitant administration of Zestril and hydrochlorothiazide further reduced blood pressure in Black and non-Black patients and any racial differences in blood pressure response were no longer evident.
Total parenteral nutrition (TPN) provides lifesaving nutritional support intravenously; however, it is associated with significant side effects. Given gut microbial alterations noted with TPN, we hypothesized that transferring fecal microbiota from healthy controls would restore gut-systemic signaling in TPN and mitigate injury. Using our novel ambulatory model (US Patent: US 63/136,165), 31 piglets were randomly allocated to enteral nutrition (EN), TPN only, TPN + antibiotics (TPN-A), or TPN + intraduodenal fecal microbiota transplant (TPN + FMT) for 14 days. Gut, liver, and serum were assessed through histology, biochemistry, and qPCR. Stool samples underwent 16 s rRNA sequencing. Permutational multivariate analysis of variance, Jaccard, and Bray-Curtis metrics were performed. Significant bilirubin elevation in TPN and TPN-A versus EN (P < 0.0001) was prevented with FMT. IFN-G, TNF-α, IL-β, IL-8, and lipopolysaccharide (LPS) were significantly higher in TPN (P = 0.009, P = 0.001, P = 0.043, P = 0.011, P < 0.0001), with preservation upon FMT. Significant gut atrophy by villous-to-crypt ratio in TPN (P < 0.0001) and TPN-A (P = 0.0001) versus EN was prevented by FMT (P = 0.426 vs. EN). Microbiota profiles using principal coordinate analysis demonstrated significant FMT and EN overlap, with the largest separation in TPN-A followed by TPN, driven primarily by Firmicutes and Fusobacteria. TPN-altered gut barrier was preserved upon FMT; upregulated cholesterol 7 α-hydroxylase and bile salt export pump in TPN and TPN-A and downregulated fibroblast growth factor receptor 4, EGF, farnesoid X receptor, and Takeda G Protein-coupled Receptor 5 (TGR5) versus EN was prevented by FMT. This study provides novel evidence of prevention of gut atrophy, liver injury, and microbial dysbiosis with intraduodenal FMT, challenging current paradigms into TPN injury mechanisms and underscores the importance of gut microbes as prime targets for therapeutics and drug discovery.NEW & NOTEWORTHY Intraduodenal fecal microbiota transplantation presents a novel strategy to mitigate complications associated with total parenteral nutrition (TPN), highlighting gut microbiota as a prime target for therapeutic and diagnostic approaches. These results from a highly translatable model provide hope for TPN side effect mitigation for thousands of chronically TPN-dependent patients.
Women participants receive a Healthy Living brochure and three monthly reminders to perform the following activities of healthy living: get quality sleep, walk briskly for 30 min, eat 5 servings of fruits and vegetables a day. In the second month, women select goals for healthy living.
PURPOSE:The titled agent capable of being medicated for a long period, comprising protein polysaccharide, an extract of a mycelium obtained by cultivating Basidiomyces belonging to the genus Coriolus versicolor or its fruit body with hot water or an alkali solution, containing a specific amount of protein, as an active ingredient. CONSTITUTION:A blood sugar-lowering agent comprising protein polysaccharide (e.g., krestin), an extract of a mycelium obtained by cultivating Basidiomyces belonging to the genus Coriolus versicolor or its fruit body with hot water or an alkali solution, containing 18-38wt% protein, having 5,000-300,000mol.wt. (ultracentrifugation method) as an active ingredient. The protein polysaccharide is a substance which has extremely low toxicity, hardly causes side effects, and has extreme safety to organisms. Administration is carried out orally or parenterally, but oral administration is preferable. A dose is 10-10,000mg/kg/day, preferably 20-600mg/kg/day, and it is medicated once-three times dividedly.
PROBLEM TO BE SOLVED: To obtain a dental primer capable of providing both an enamel and a dentin with high bond strength without carrying out pretreatment with an aqueous solution of an acid, by using a mixture of a phosphoric acid monoester of a specific structure and a phosphoric acid diester as a phosphate group- containing polymerizable monomer. SOLUTION: This dental primer comprises (A) 0.5-50 pts.wt., based on 100 pts.wt. of the total, of the components A to C of a phosphate group-containing polymerizable monomer, (B) 1-50 pts.wt. of a polyfunctional carboxylic acid group-containing polymerizable monomer and (C) 5-90 pts.wt. of water as main components. The component A is composed of a mixture of a compound of formula I and a compound of formula II (R1 to R3 are each a polymerizable unsaturated group-containing organic group; Z is 0 or S; X1 to X3 are each OH or a group to form an OH group by reaction with water) in the blending ration of the compounds of formula I and formula II of 1:0.75 to 1:35 by molar ratio.
Venous thromboembolism (VTE) is a major contributor to maternal morbidity and mortality. The immediate postpartum period is a high risk time for VTE, and cesarean delivery is an additional risk factor. In the United States, use of postpartum VTE prophylaxis with low-molecular weight heparin (LMWH) is commonly used but without a standard protocol or dose across all hospitals. A fixed-dose of LMWH is frequently used based on data from non-obstetric studies. However, there are concerns that in the postpartum population this fixed dose may not be adequate for prophylaxis.

This study aims to evaluate the efficacy of fixed dose versus weight-based LMWH to reach prophylactic anti-Xa levels in post-cesarean delivery women. This will be a randomized controlled trial (RCT) with half of participants receiving a fixed dose of LMWH and half of participants receiving a weight-based dose of LMWH. The hypothesis is that the use of a weight-based LMWH compared to a fixed dose will result in more women achieving prophylactic anti-Xa levels.
A system and method for visualizing and annotating temporal trends of an abnormal condition in patient data. A classification and visualization module detects one or more conditions in one or more images, e.g. X-ray images, and visualizes the condition on the image. A temporal disease state extraction module analyzes text, e.g. radiology reports, for indications of a change in the condition. A multimodal disease state comparison module fuses the extracted data into a compact representation of the condition changes over time.
This daily health information measuring apparatus comprises a daily activity database, cameras, microphones, an analysis unit, and an inquiry unit. The daily activity database stores users' daily activities. The cameras provide image data. The microphones provide sound data. The analysis unit creates user IDs on the basis of the image and sound data received from the cameras and microphones, creates activity patterns, and stores the user IDs and data relating to the activity patterns in the daily activity database. The inquiry unit receives inquiry user IDs and inquiry periods, searches the daily activity database for inquiry users' activity patterns and the time durations of the activity patterns, and calculates and provides the total amounts of calories consumed by the inquiry users during the inquiry periods.
Sodium nitroprusside should not be used in the treatment of compensatory hypertension, where the primary hemodynamic lesion is aortic coarctation or arteriovenous shunting. 

Sodium nitroprusside should not be used to produce hypotension during surgery in patients with known inadequate cerebral circulation, or in moribund patients (A.S.A. Class 5E) coming to emergency surgery. 

Patients with congenital (Leber's) optic atrophy or with tobacco amblyopia have unusually high cyanide/thiocyanate ratios. These rare conditions are probably associated with defective or absent rhodanase, and sodium nitroprusside should be avoided in these patients. 

Sodium nitroprusside should not be used for the treatment of acute congestive heart failure associated with reduced peripheral vascular resistance such as high-output heart failure that may be seen in endotoxic sepsis.
Home visitation is a prevention program for sociodemographically high risk, first-time mothers and their families that is designed to optimize child health and development. Most home visitation programs seek to engage fathers in the service and promote greater positive involvement with their children, although systematic and efficacious strategies to achieve this have not been developed and tested. Yet, it is well-documented that positive father involvement and mutually supportive relationships between fathers and mothers impart direct benefits to both children and their parents. Building upon previous efforts to incorporate evidence-based interventions into the home visitation setting, this study seeks to adapt Family Foundations, a coparenting intervention with a strong empirical foundation, as an augmented strategy in ongoing home visitation. In a first phase of qualitative investigation, we will adapt the format and content of Family Foundations for implementation in the home, addressing the needs of high risk mothers and fathers, and integrate it into standard home visitation services. In a second phase, a clinical trial will be conducted to determine the efficacy of the adapted intervention (HVFF) in contrast to a control condition of home visitation alone (HVA). Specifically, 300 mother/father dyads in home visitation will be recruited prenatally and randomly assigned to HVFF and HVA conditions. HVFF will consist of 8 in-home and 2 group sessions administered weekly and in two equal parts at approximately 2 months before birth and 4 months postpartum. Both the HVFF and HVA participants will be assessed at pre-intervention, post-intervention (5 months postpartum), and 9 and 18 month follow-ups. A comprehensive assessment battery will be administered at each assessment measuring parental cooperation, quality of parental relationship, father involvement, beliefs about parenting, parental psychological adjustment, and intimate partner violence. After the child's birth, child development and social/emotional adjustment will be measured and parenting practices will be videotaped and subsequently rated for parenting quality. It is hypothesized that, relative to controls, fathers in the HVFF condition will participate more frequently and more positively in standard home visits and will be more involved with their children; mothers and fathers in the HVFF condition will have higher levels of coparenting, and lower levels of depression, parental stress, and child abuse potential; and children in the HVFF condition will be more behaviorally and emotionally well-adjusted. Mediators of intervention outcomes will also be explored.
Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding of subgingival community dynamics. Certain pathobionts can orchestrate the establishment of dysbiotic communities that can subvert the host immune system, triggering inflammation and tissue destruction. Yet, diagnosis and management of periodontal conditions still rely on clinical and radiographic examinations, overlooking the well-established microbial etiology. This review summarizes the chronological emergence of periodontal etiological models and the co-evolution with technological advances in microbial detection. We additionally review the microbial analytical approaches currently accessible to clinicians, highlighting their value in broadening the periodontal assessment. The epidemiological importance of obtaining culture-based antimicrobial susceptibility profiles of periodontal taxa for antibiotic resistance surveillance is also underscored, together with clinically relevant analytical approaches to guide antibiotherapy choices, when necessary. Furthermore, the importance of 16S-based community and shotgun metagenomic profiling is discussed in outlining dysbiotic microbial signatures. Because dysbiosis precedes periodontal damage, biomarker identification offers early diagnostic possibilities to forestall disease relapses during maintenance. Altogether, this review highlights the underutilized potential of clinical microbiology in periodontology, spotlighting the clinical areas most conductive to its diagnostic implementation for enhancing prevention, treatment predictability, and addressing global antibiotic resistance.
BACKGROUND: This article describes the Steps to Confident Parenting (SCP) program, developed by an Australian family service consortium. The SCP integrates home-based and case-management services to enhance the skills of parents with a diagnosed or suspected intellectual disability/cognitive impairment and to prevent child protection interventions.
METHOD: 'Program explication' methodology documented the components/activities, and underpinning evidence for this practitioner designed service through interviews with nine agency staff. A literature review evaluated evidence for the implicit program benefit theory.
RESULTS AND CONCLUSION: The SCP comprised five logically consistent components-Targeted Referral, Assessments, Initial Consultation, Program Delivery, Closure and Follow-up. Components generally had 'some' supportive evidence, however there was a 'lack of' evidence for Closure and Follow-up. In the context of a partnership seeking to build the evidence for the SCP, it was recommended that a protocol for a randomised trial evaluation with longer term follow-up be drafted by the consortia.
A high-level of motor control often requires complex processing of sensory information. Such a cognitive aspect of motor control is supposed to share underlying neural components with non-motor, cognitive operations. The present study is aimed to clarify the similarity and difference between cognitive processing for motor control and non-motor, cognitive processing, especially in terms of the speed of processing. From this standpoint, patients with Parkinson's disease who manifest motor slowing as well as possible cognitive slowing will provide an interesting model to explore similar control mechanisms of speed for motor and non-motor behavioral control. Using psychophysical observations, we will try to clarify normal and diseased control of motor and cognitive speed. Furthermore, using functional magnetic resonance imaging (fMRI), we will explore the neural correlates underlying control of motor and cognitive speed in normal brains as well as pathologic brains. Blood-oxygen-level-dependent signal changes measured by fMRI, as an index of the activity of a neural population, are expected to reveal underactivity or compensatory overactivity in the functionally impaired brain areas responsible for slowing of movement, thinking, or both. This study may provide a new framework to explain the relationship between motor and cognitive aspects of human behavior and help to clarify the pathophysiology of Parkinson's disease.
PROBLEM TO BE SOLVED: To protect skin and enable to activate a horny layer. SOLUTION: This cosmetic is obtained by dispersing a platinum colloid in a base material. The base material a water soluble ingredient for adhering the platinum colloid to a human body and the platinum colloid is produced by sequentially carrying out a reduction processing and a filtration processing. Polysorbate 80 is used as a surfactant, a chloroplatinic acid solution as a platinum ion solution and a sodium hydrogen carbonate as a pH compensator. Oxidation-reduction potential after finishing the reduction expresses <=-400 mV. Horny layers are activated by applying the cosmetic on the human skin by electric double layer effect which the negatively charged platinum colloid has.
Drug: Plamotamab will be administered at a lower dose in addition to tafasitamab (12 milligrams \[mg\]/kilograms \[kg\] intravenously) plus lenalidomide (25 mg orally). This cohort was planned to enroll sequentially prior to Part 1B.
The study includes 2 parts, phase IIa and IIb. Phase IIa is to evaluate the preliminary safety, pharmacokinetic characteristics and efficacy of HL-085, and to determine the recommended dose. To observe the 9mg dose level, approximately 15 patients will receive HL-085 at a dose of 9mg BID on a continuous dosing schedule(1 cycle=21 days). The investigator and sponsor will evaluate the safety and efficacy data to determine whether HL-085 9mg BID is appropriate. HL-085 12mg BID, 6mg BID, or other HL-085 dosing regimen will be observed as needed. A total of 15-35 patients will be enrolled in phase IIa. Phase IIb is to further evaluate the safety and efficacy of HL-085 in patients with NF1 and inoperable PN and is expected to enroll 35 patients.