anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition containing soy bean extract and ginseng extract for preventing obesity or hyperlipidemia is provided to ensure similar effect with Xenical and safety. CONSTITUTION: A composition for preventing or treating obesity or hyperlipidemia contains soy bean extract and ginseng extract as active ingredient. The extract of soy bean and ginseng is fermented. The fermented soy bean extract contains glycitein, soyasapogenol B or its mixture. The fermented ginseng extract contains compound K, compound Y, ginsenoside Rh2 or their mixture. The composition further comprises acanthopanax extract and is pharmaceutical or sitological composition.
Systems, devices, and methods to measure interstitial concentration of selected compounds over time to provide early detection of shock are described. In an example method, interstitial fluid is obtained from a subject. Analytes are detected in the interstitial fluid. At least one of the analytes corresponds to hypoxia of a tissue of the subject and at least one other analyte corresponds to vascular permeability of the subject. The example method further includes determining whether the subject is in shock based on a computing model and the detected analytes and generating an alert based on whether the subject is in shock. Treatments can be administered following the alert generation.
Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis mouse model for an evaluation system for such cases, and aimed to investigate the effectiveness and mechanisms of action of several drugs commonly used as antipruritics in Japan, utilizing this model. Mice 69-80 weeks old were used as aged mice, and the level of mechanical alloknesis was counted as the number of scratching behaviours in response to innocuous stimuli. Bepotastine, neurotropin, pregabalin, baricitinib, and abrocitinib were used as antipruritics, and yohimbine and methysergide as inhibitors of the descending inhibitory pathway. The findings suggest that mechanical alloknesis in aged mice is a suitable animal model for assessing pruritus in the elderly without xerosis, and pregabalin, neurotropin, baricitinib, and abrocitinib may be effective antipruritics in the elderly through activating both the noradrenergic and serotonergic descending inhibitory pathways. These findings may be useful for the selection of antipruritics for pruritus in the elderly without skin lesions or dryness.
A fluid infusion system as described herein includes a number of local “body network” devices, such as an infusion pump, a handheld monitor or controller, a physiological sensor, and a bedside or hospital monitor. The body network devices can be configured to support communication of status data, physiological information, alerts, control signals, and other information between one another. In addition, the body network devices can be configured to support networked communication of status data, physiological information, alerts, control signals, and other information between the body network devices and “external” devices, systems, or communication networks. Such external communication allows the infusion system to be extended beyond the traditional short-range user environment. One particular system embodiment includes a network router device that functions as a centralized storage, processing, and routing unit for data received from the body network devices. The network router device is configured to generate HTML documents (web pages) to facilitate Internet-based setup, management, and control.
Two sessions, each lasting 60-minutes total. The first session involves standard hand therapy care for the entire session. The second session begins with the participant listening to a 19-minute audio-recorded body scan (i.e., mindfulness training), followed by standard care.
A composition according to the present invention contains ginseng, Sophora flavescens AIT. roots, Scrophularia buergeriana Miquel roots, Salvia miltiorrhiza Bunge roots, and Adenophora stricta Miq. roots, and has an effect of promoting collagen production and angiogenesis. Thus, the composition can be used as a cosmetic composition, a food composition, a pharmaceutical composition, and the like. The composition of the present invention contains ginseng, Sophora flavescens AIT. roots, Scrophularia buergeriana Miquel roots, Salvia miltiorrhiza Bunge roots, and Adenophora stricta Miq. roots, in a dry weight ratio of 1.5-2 : 0.02-0.04 : 0.4-0.5 : 0.005-0.015 : 0.005-0.015.
PURPOSE: Utilisation of remote clinics is increasing in healthcare settings worldwide. During the height of the COVID pandemic, our UK-based teaching hospital has trialled telephone assessment for new patients presenting with primary hernias. Selected cases are listed for elective repair of primary hernia direct from telephone clinic assessment. In March 2021, after this process had been in place for 13 months, departmental triage criteria were introduced, allocating patients to initial assessment in Face to Face or Telephone Clinics. Here, we evaluate the effectiveness of telephone assessment, with specific attention to 'Day of Surgery' cancellation. We also assess the effect of our triage criteria on rate of 'Day of Surgery' cancellation.
METHODS: Departmental diaries were studied retrospectively to identify patients listed for hernia repair between February 2020 and February 2022. Data were obtained from clinic letters, discharge paperwork and operating lists, as well as from management teams. Fishers Exact test was used to compare groups seen either face to face or remotely as well and pre- and post-intervention.
RESULTS: 325 patients were listed for hernia repair, 56 after telephone assessment. 6 (11%) of those listed from telephone clinic were cancelled on the day of surgery, compared with 34 (13%) of those seen face to face. With triage criteria in place, listing from telephone clinic increased significantly from 14 to 27%. Overall day of surgery cancellations reduced from 13 to 9%. Rate of day of surgery cancellation in those assessed in telephone clinic reduced from 12 to 9%.
CONCLUSIONS: There is no significant difference between day of surgery cancellations after face to face or telephone clinic assessment. Triage criteria for telephone assessment appear to increase the numbers being listed after remote clinics. This did not significantly impact the number of day of surgery cancellations.
Safety data will be generated during the multi-dose PK and PD study, as DLT is not anticipated in the single-dose PK study. Enrollment into dose cohorts 1 and 2 can occur on a continuous basis. Enrollment for dose cohorts 3 and 4 will be done sequentially using a modified 3+3 design (see Section 8.2). The first three subjects enrolled into a dose cohort must complete at least 21 days of the multi-dose PK/PD study without a DLT before the remaining 4 subjects in the cohort can be enrolled.
Subjects meeting COHORT 2 inclusion criteria, who have UNILATERAL "severe leg injuries". Unilateral injuries include patients who meet the inclusion criteria for a "severe lower extremity injury" for ONE lower extremity, with no more than a simple soft tissue injury (eg, simple laceration) on the contralateral leg.
Oral non-steroidal anti inflammatory drugs (NSAIDs) are not an effective treatment of Alzheimer's disease, because the brain dose is too low. Nasal delivery of NSAIDs such as ibuprofen, flurbiprofen, indomethacin, diclofenac, or naproxen, which inhibit the enzymes cyclooxygenase-1 (cox-1) and cox-2, are used to prevent and/or treat Alzheimer's disease, a low grade brain inflammation. The large amount of nasal NSAIDs (e.g., ibuprofen, flurbiprofen, indomethacin, diclofenac, or naproxen) that reaches the brain far exceeds that from an oral dose. Low-molecular-weight lipophilic drugs, such as ibuprofen, naproxen, indomethacin, diclofenac, and flurbiprofen, are readily absorbed into the brain by the intranasal route. Alzheimer's starts in the entorhinal cortex, which is closely connected to the olfactory nerves, and spreads anatomically in a defined pattern. Therefore, a nasal NSAID would readily reach the region of the brain where it acts therapeutically.
Subjects will be provided with the placement of an Injectrode insert. The maximal placement duration will be 28 days.
A rapidly-cleared anesthetic drug such as propofol can be used to treat migraine or cluster headaches and other 'runaway pain' conditions. When used at a sub-anesthetic dosage level that does not cause a loss of consciousness, propofol (a drug used in surgical anesthesia, which is normally injected but which also can be inhaled) induces a feeling of sedated relaxation. This sedated relaxed condition can interrupt and stop a 'runaway pain' condition such as a migraine or cluster headache, as well as various types of intractable chronic pain, such as trigeminal facial pain or arachnoiditis. Typical treatments have used about 2 to 3 ml initially, followed by additional 2-3 ml boluses at timed intervals, depending on the pain status reported by the patient. When a desired level of sedation is reached and the patient reports that the pain is gone, the drug is terminated. It should be rapidly metabolized and eliminated from the blood, so that patients can recover quickly to an alert and functioning state (usually within 10 to 15 minutes, when propofol is used) and can safely drive away from a clinic and return to work or other normal activities, with no unpleasant side-effects or lingering after-effects. In tests on patients suffering acute migraine or cluster headaches or early-onset symptoms of cluster headache, most patients reported 100% relief with no problems of rebound headache the following day. In patients treated for chronic intractable pain, propofol treatment usually provided effective pain relief for about 3 to 5 days before another treatment was needed.
The increasing number of spinal injuries and pathologies directs the need of technological advancement in spinal surgeries and its approaches in Pakistan. Among various expansion in surgical procedures; minimally invasive surgery of spine has gaining more advantage for spinal decompression, spinal fusion and instrumentation over lumbar, thoracic and cervical spine areas considering multilevel pathology.(1) Minimally invasive spine surgery (MISS), has attracted increasing attention within the last decade. The common thread between all minimally invasive spine surgeries is use of smaller incisions and less deterioration of surrounding soft tissue, typically results in less pain after surgery and a faster recovery with reduced length of stay at hospital. The patient reported functional outcome after this procedure was found to be better in comparison with the open approach procedures.(2) Therapeutic exercise post-operatively was programmed to maximize recovery and to minimize potential future problems including disability and improving quality of life. Three different approaches for post-operative management has been practiced including: 1. Recovery phase: 4 to 16 weeks of limited activity following the surgery, 2. eliminating post-operative activity restriction leads to enhanced short-term outcomes for patients after limited open discectomy, 3. Incorporating therapeutic exercise intervention program.(3) The purpose of therapeutic exercise post-operatively was to maximize recovery and to minimize potential future problems including disability and improving quality of life. (4)The therapeutic intervention program comprises of two components: patient education and exercise therapy based on protocols by clinical expertise considering the philosophy of surgeon. Patient education comprises of a one hour counseling session. Therapeutic exercise program encompasses trunk strengthening exercises (both isometrics and dynamics) along with core stabilization exercises and endurance training. (5)
(1) Background: Obesity, a poor diet, and inactivity are major health issues among Saudi youth. However, satisfaction with unhealthy lifestyles could impede change. This study assessed lifestyle factors and related satisfaction among Saudi university students. (2) Methods: In this cross-sectional study, 1957 students at Jazan University completed surveys on demographics, physical activity, dietary habits, and 10-point satisfaction scales for weight, activity, and diet. Chi-squared tests and logistic regression were used to analyze the associations between behaviors and satisfaction. (3) Results: Overweight/obesity prevalence was 25.45%, and only 26.67% of the subjects met activity guidelines. Many of them exhibited poor dietary habits. Despite unhealthy behaviors, some expressed high satisfaction, especially regarding their diets. Subjects with a normal BMI had the highest weight satisfaction. Activity satisfaction increased with higher activity levels. Dietary satisfaction was minimally impacted by healthfulness. Males and higher incomes were correlated with greater satisfaction. (4) Conclusions: A concerning paradox exists between unhealthy lifestyles and satisfaction among Saudi university students, particularly regarding their diets. Multicomponent interventions informed by behavior change theories and employing motivational techniques are urgently needed to address this disconnect and facilitate positive behavior change.
Patients undergoing VATS or wedge resection procedures will be informed and their consent will be obtained prior to the procedure. Individuals who consent and meet the inclusion criteria will fill out a personal information form and then be randomly assigned to groups using simple randomization method. Breathing exercises will be taught individually to participants in the experimental group by the researcher. In the experimental group, breathing exercises will be performed approximately 10 minutes, four times a day, starting from the first day after oral intake.
PURPOSE:To enable exact short file assortment in a short time by carrying out assortment instructing correct assorting targets, upon reading patients' No. from chart file to be assorted and collating with the patient registered file. CONSTITUTION:A host computer 12 upon patient reception at the receiving terminal 11, registers the name, date of birth, etc., of the new patient and in case of revisit, retrieves the registered file. Thence, the host computer, registers the date of visit, type of treatment on the register file of the accepted patient, preparing a patient record, and transmits to an exclusive computer 13. The exclusive computer 13 receives withdrawal conditions such as patients' record, the chart file required for that day and carries out location registration which is the host file positioning information for retrieval. The exclusive computer 13, rearranges the host file number to be withdrawn according to order of location in the storage shelf, and based on the location issues indicates for withdrawal to the storage shelf. Thence withdraws the desired short file from the storage shelf and conveys to the assorter 16.
Veterans randomized to the intervention arm will be enrolled in the HT program, provided with standard telemonitoring equipment by HT nursing staff (current HT practice at DVAMC is use of the Health Buddy 3 device for patients with landline phones and the Cardiocom Interactive Voice Response System for patients with cell phones), and will receive the study intervention for 6 months. Veterans without depressive symptoms on baseline PHQ-9 assessment (PHQ-9 \< 10) will not initially be entered into the depressive symptom management component of the intervention, but will be monitored for new symptoms throughout the intervention.
BACKGROUND: If tibiofibular syndesmotic injury is undetected, chronic instability may lead to persistent pain and osteoarthritis. So far, no reliable diagnostic method has been available. The primary objectives of this study were to determine whether defined lesions of the syndesmosis can be correlated with specific tibiofibular joint displacements caused by external rotational torque and to compare the performance of bilateral external torque computed tomography (BET-CT) and arthroscopy. Secondary objectives included an evaluation of the reliability of CT measurements and the suitability of the healthy contralateral ankle as a reference.
METHODS: Seven pairs of healthy, cadaveric lower legs were tested and assigned to 2 groups: (1) supination-external rotation (SER) and (2) pronation-external rotation (PER). In the intact state and after each surgical step, an ankle arthroscopy and 3 CT scans were performed. During the scans, the specimens were placed in an external torque device with 2.5, 5.0, and 7.5 Nm of torque applied.
RESULTS: The arthroscopic and CT parameters showed significant correlations in all pairwise comparisons. The receiver operating characteristic (ROC) curve analyses yielded the best prediction of syndesmotic instability with the anterior tibiofibular distance on CT, with a sensitivity of 84.1% and a specificity of 95.2% (area under the curve [AUC], 94.8%; 95% confidence interval [CI], 0.916 to 0.979; p < 0.0001) and with the middle tibiofibular distance on arthroscopy, with a sensitivity of 76.2% and specificity of 92.3% (AUC, 91.2%; 95% CI, 0.837 to 0.987; p < 0.0001). Higher torque amounts increased the rate of true-positive results.
CONCLUSIONS: BET-CT reliably detects experimental syndesmotic rotational instability, compared with the healthy side, with greater sensitivity and similar specificity compared with the arthroscopic lateral hook test. Translation of these experimental findings to clinical practice remains to be established.
LEVEL OF EVIDENCE: Diagnostic Level III . See Instructions for Authors for a complete description of levels of evidence.
Safety and efficacy of MultiHance for use in MRA were evaluated in two prospective, multi-center, open-label, clinical trials (one for each arterial vascular territory: renal and aorto-ilio-femoral). Out of 580 patients who received Multihance in these two trials, 62.2% were men and 90.9% were Caucasian; the average age was 63.4 years (range 18 to 93 years). In both trials, patients with known or suspected arterial disease underwent MRA with and without MultiHance as well as catheter-based digital subtraction angiography (DSA). Assessment of diagnostic efficacy for detecting/excluding clinically significant steno-occlusive disease (≥ 51% stenosis measured with electronic calipers) was based on comparisons of sensitivity and specificity between MultiHance MRA and non-contrast MRA, with DSA as a reference standard.

In each vascular territory, the primary efficacy analyses were designed to demonstrate superiority in sensitivity and non-inferiority in specificity of MultiHance MRA to non-contrast MRA at the vessel-segment level. The interpretation of MRA images from both trials was conducted by three independent radiologist readers who were blinded to clinical data, including the DSA results. The pre-specified success criteria were to be achieved by at least the same two readers for all primary analyses.

Results of both trials showed a statistically significant increase in sensitivity and specificity of MultiHance MRA over non-contrast MRA in detecting clinically significant steno-occlusive disease.

Table 5 summarizes the efficacy results by reader.
A composition for improving brain function and cognitive function is provided to improve the functions using alcohol of Betula platy phylla extract and its fraction. A composition for improving brain function and cognitive function comprises C1-4 alcohol extract of Betula platy phylla bark only or pharmaceutically or sitologically allowable excipient. The composition also comprises organic solvent fraction of C1-4 alcohol extract of Betula platy phylla bark only or further comprises pharmaceutically or sitologically allowable excipient. The fraction is obtained using butanol, hexane, ether, ethyl acetate, chloroform, dichloromethane, benzene, and acetone. The composition is used in treating and preventing memory loss, damage of memory, amnesia, or Alzheimer disease. A health food containing the composition is used in a form of tablet, capsule, powder, granule, liquid, and pill.
FIELD: food and pharmaceutical industry. SUBSTANCE: biologically active substances are obtained from sea buckthorn raw - fruits and leaves pulp or their mixture by extraction with 90-96% ethyl alcohol at its boiling point under vacuum. Obtained extract is diluted with distilled water. Method provides preparing lipid fraction and concomitant carotinoids, chlorophylls and water-soluble biologically active substances simultaneously. The end product exhibits a decreased acid number and does not contain harmful impurity traces. EFFECT: improved method preparing, enhanced quality of the end product. 1 tbl
Fructose consumption has increased over the years, especially in adolescents living in urban areas. Growing evidence indicates that daily fructose consumption leads to some pathological conditions, including memory impairment. This review summarizes relevant data describing cognitive deficits after fructose intake and analyzes the underlying neurobiological mechanisms. Preclinical experiments show sex-related deficits in spatial memory; that is, while males exhibit significant imbalances in spatial processing, females seem unaffected by dietary supplementation with fructose. Recognition memory has also been evaluated; however, only female rodents show a significant decline in the novel object recognition test performance. According to mechanistic evidence, fructose intake induces neuroinflammation, mitochondrial dysfunction, and oxidative stress in the short term. Subsequently, these mechanisms can trigger other long-term effects, such as inhibition of neurogenesis, downregulation of trophic factors and receptors, weakening of synaptic plasticity, and long-term potentiation decay. Integrating all these neurobiological mechanisms will help us understand the cellular and molecular processes that trigger the memory impairment induced by fructose.
Participants will be randomized to receive Placebo. The study will be conducted in 4 parts. Part A: Single ascending dose (SAD). Part B,C and D: Multiple ascending dose (MAD).
Insulin resistance (IR) was found to be a critical element in the pathogenesis of Parkinson's disease (PD), facilitating abnormal α-synuclein (α-Syn) aggregation in neurons and thus promoting PD development. However, how IR contributes to abnormal α-Syn aggregation remains ill-defined. Here, we analyzed six PD postmortem brain transcriptome datasets to reveal module genes implicated in IR-mediated α-Syn aggregation. In addition, we induced IR in cultured dopaminergic (DA) neurons overexpressing α-Syn to identify IR-modulated differentially expressed genes (DEGs). Integrated analysis of data from PD patients and cultured neurons revealed 226 genes involved in α-Syn aggregation under IR conditions, of which 53 exhibited differential expression between PD patients and controls. Subsequently, we conducted an integrated analysis of the 53 IR-modulated genes employing transcriptome data from PD patients with different Braak stages and DA neuron subclasses with varying α-Syn aggregation scores. Protein tyrosine phosphatase receptor type O (PTPRO) was identified to be closely associated with PD progression and α-Syn aggregation. Experimental validation in a cultured PD cell model confirmed that both mRNA and protein of PTPRO were reduced under IR conditions, and the downregulation of PTPRO significantly facilitated α-Syn aggregation and cell death. Collectively, our findings identified PTPRO as a key regulator in IR-mediated α-Syn aggregation and uncovered its prospective utility as a therapeutic target in PD patients with IR.