anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition containing bamboo leaf or green tea extract is provided to promote transglutaminase-1 synthesis and skin moisturizing. CONSTITUTION: A composition for skin moisturizing contains 0.001-10.0 wt% of one or more extract as an active ingredient, which is prepared by enzyme treatment of bamboo leaves or green tea. The composition further contains 0.001-10.0 wt% of extract of soybeans, Nymphaea alba, or Opuntia Ficus-indica var. saboten. The used enzyme is amylase, protease, glycosidase, lactase, sucrose, or maltase. The composition promotes the synthesis of transglutaminase-1.
BACKGROUND: The gut microbiota plays a vital role in the development of sepsis and in protecting against pneumonia. Previous studies have demonstrated the existence of the gut-lung axis and the interaction between the gut and the lung, which is related to the prognosis of critically ill patients; however, most of these studies focused on chronic lung diseases and influenza virus infections. The purpose of this study was to investigate the effect of faecal microbiota transplantation (FMT) on Klebsiella pneumoniae-related pulmonary infection via the gut-lung axis and to compare the effects of FMT with those of traditional antibiotics to identify new therapeutic strategies.
METHODS: We divided the mice into six groups: the blank control (PBS), pneumonia-derived sepsis (KP), pneumonia-derived sepsis + antibiotic (KP + PIP), pneumonia-derived sepsis + faecal microbiota transplantation(KP + FMT), antibiotic treatment control (KP+PIP+PBS), and pneumonia-derived sepsis+ antibiotic + faecal microbiota transplantation (KP + PIP + FMT) groups to compare the survival of mice, lung injury, inflammation response, airway barrier function and the intestinal flora, metabolites and drug resistance genes in each group.
RESULTS: Alterations in specific intestinal flora can occur in the gut of patients with pneumonia-derived sepsis caused by Klebsiella pneumoniae. Compared with those in the faecal microbiota transplantation group, the antibiotic treatment group had lower levels of proinflammatory factors and higher levels of anti-inflammatory factors but less amelioration of lung pathology and improvement of airway epithelial barrier function. Additionally, the increase in opportunistic pathogens and drug resistance-related genes in the gut of mice was accompanied by decreased production of favourable fatty acids such as acetic acid, propionic acid, butyric acid, decanoic acid, and secondary bile acids such as chenodeoxycholic acid 3-sulfate, isodeoxycholic acid, taurodeoxycholic acid, and 3-dehydrocholic acid; the levels of these metabolites were restored by faecal microbiota transplantation. Faecal microbiota transplantation after antibiotic treatment can gradually ameliorate gut microbiota disorder caused by antibiotic treatment and reduce the number of drug resistance genes induced by antibiotics.
CONCLUSION: In contrast to direct antibiotic treatment, faecal microbiota transplantation improves the prognosis of mice with pneumonia-derived sepsis caused by Klebsiella pneumoniae by improving the structure of the intestinal flora and increasing the level of beneficial metabolites, fatty acids and secondary bile acids, thereby reducing systemic inflammation, repairing the barrier function of alveolar epithelial cells, and alleviating pathological damage to the lungs. The combination of antibiotics with faecal microbiota transplantation significantly alleviates intestinal microbiota disorder, reduces the selection for drug resistance genes caused by antibiotics, and mitigates lung lesions; these effects are superior to those following antibiotic monotherapy.
Skin scarring and fibrosis affect millions of people worldwide, representing a serious clinical problem causing physical and psychological challenges for patients. Stem cell therapy and regenerative surgery represent a new area of treatment focused on promoting the body's natural ability to repair damaged tissue. Adipose-derived stem cells (ASCs) represent an optimal choice for practical regenerative medicine due to their abundance, autologous tissue origin, non-immunogenicity, and ease of access with minimal morbidity for patients. This review of the literature explores the current body of evidence around the use of ASCs-based regenerative strategies for the treatment of scarring and skin fibrosis, exploring the different surgical approaches and their application in multiple fibrotic skin conditions. Human, animal, and in vitro studies demonstrate that ASCs present potentialities in modifying scar tissue and fibrosis by suppressing extracellular matrix (ECM) synthesis and promoting the degradation of their constituents. Through softening skin fibrosis, function and overall quality of life may be considerably enhanced in different patient cohorts presenting with scar-related symptoms. The use of stem cell therapies for skin scar repair and regeneration represents a paradigm shift, offering potential alternative therapeutic avenues for fibrosis, a condition that currently lacks a cure.
A system for providing surgical planning and guidance with three-dimensional visualization is disclosed. In particular, the system obtains an image set of an anatomy of interest of a subject, and renders the image set on a user interface using volume rendering. Notably, the system accomplishes the foregoing without generating surface models or conducting bone contouring. The system may, during generation of an implant plan for implanting an implant onto the anatomy of interest, suggest landmark points in the volume rendered image set. Once the landmark points are confirmed, the system may facilitate implant positioning via implant controls. The system conducts a registration process to confirm a match between the physical anatomy of interest and the information contained in volume-rendered image set in the plan. If there is a match, the system may facilitate performance of a surgical procedure for implanting the implant onto the anatomy of interest of the subject.
Brachial plexus blockade-based upper-extremity regional anesthetic approaches have been demonstrated to lessen opioid administration side effects, increase patient satisfaction, and offer noticeably better analgesia right after these surgeries. A lot of drugs have been tested to prolong and improve the analgesic effect of long-acting local anesthetics (LA). Currently, dexamethasone and dexmedetomidine have been studied, looking for an optimal, long-lasting single-shot nerve block. Adjuvants have generally been employed in peripheral nerve blocks to lengthen the block effects, limit secondary toxic effects and plasmatic absorption, and speed the onset of the block. Objectives: To compare the effects of adding dexmedetomidine and dexamethasone to bupivacaine on the start of sensory blockade in an infraclavicular brachial plexus block. Patients and Methods: A prospective, randomized controlled trial will be conducted on patients who are undergoing hand or forearm surgeries. Patients who will be eligible for the study will be divided into 2 groups. The first group will receive dexmedetomidine and dexamethasone as adjuvants to bupivacaine, while the second group will receive bupivacaine alone. Expected Results: The success rate, onset time, duration of the block, and possible adverse events.
The starting dose for TECFIDERA is 120 mg twice a day orally. After 7 days, the dose should be increased to the maintenance dose of 240 mg twice a day orally. Temporary dose reductions to 120 mg twice a day may be considered for individuals who do not tolerate the maintenance dose. Within 4 weeks, the recommended dose of 240 mg twice a day should be resumed. Discontinuation of TECFIDERA should be considered for patients unable to tolerate return to the maintenance dose. The incidence of flushing may be reduced by administration of TECFIDERA with food. Alternatively, administration of non-enteric coated aspirin (up to a dose of 325 mg) 30 minutes prior to TECFIDERA dosing may reduce the incidence or severity of flushing [see Clinical Pharmacology (12.3)]. 

TECFIDERA should be swallowed whole and intact. TECFIDERA should not be crushed or chewed, and the capsule contents should not be sprinkled on food. TECFIDERA can be taken with or without food.
Renal ex vivo normothermic machine perfusion (NMP) is under development as an assessment tool for high-risk kidney grafts and as a means of achieving more physiologically accurate organ preservation. On-going hemolysis has been reported during NMP, as this technique relies on red blood cells for oxygen delivery. In this study, we confirm the occurrence of progressive hemolysis during 6-hour kidney NMP. NMP-associated erythrostasis in the glomeruli and in peri-glomerular vascular networks points to an interaction between the red blood cells and the graft. Continuous hemolysis resulted in prooxidative changes in the perfusate, which could be quenched by addition of fresh frozen plasma. In a cell-based system, this hemolysis induced redox stress and exhibited toxic effects at high concentrations. These findings highlight the need for a more refined oxygen carrier in the context of renal NMP.
Infrared surgical navigation (IRSN). Pedicle screw placement using Brainlab Curve 1.2 combined with Medtronic o-arm for imaging.
A method, computer system, and computer program product for ad-hoc training injection are provided. The embodiment may include receiving a user learning plan. The embodiment may also include processing the received user learning plan by dividing content into smaller pieces. The embodiment may further include determining a current user mental state. The embodiment may also include determining an optimum time for a user to engage in the learning plan. The embodiment may further include presenting one of the smaller pieces at the determined optimum time.
The dose of amifampridine was based on optimal neuromuscular benefit determined from the Run-in Period from SMA-001 or could be modified as the discretion of the Investigator. The maximum single dose was 20 mg. The dose range for patients 6 to 16 years of age was 15 to 60 mg, and for those 17 years and older the range was from 30 to 80 mg daily.
Participants with PR or CR after induction phase who will be randomized to maintenance arm will receive rituximab treatment for 8 cycles. Twelve weeks after the last induction cycle, participants will receive rituximab at a dose of 375 mg/m\^2 as IV infusion on Day 1 of each 12-week cycle until disease progression (up to approximately 96 weeks).
PURPOSE:A material providing artificial dentition and plate capable of preventing effectively adhesion and attachment of foods, chewing easily tacky and adherent foods, obtained by adding a powdery substance component to provide adhesion to a synthetic resin component. CONSTITUTION:Preferably 10-60wt% powdery substance to provide nonadhesion is added to a synthetic resin for artificial dentition and plate, such as acrylic resin, polymethyl methacrylate, polycarbonate, epoxy resin, etc. Powder with 0.2-50mu particle diameter of an organic substance such as tetrafluoroethylene polymer, perfluoro alkoxy resin, polyacetal, etc. or powder with 0.1-90mu particle diameter of inorganic substance such as calcium carbonate, silica, talc clay, alumina, etc. is used as the substance to provide nonadhesion. Artificial dentition and plate obtained from this material have improved physical properties such as compression strength and wear resistance, are provided with nonadhesion.
Radical cystectomy is the gold standard for muscle-invasive bladder. Orthotopic ileal neobladder, as one of the urinary diversion methods, is preferred whenever possible to achieve a better postoperative quality of life. After surgery, the patient usually indwells a catheter until the anastomotic site heals. And the urinary indwelling time may have an effect on early continence. This is a prospective study including patients undergoing RARC with orthotopic ileal neobladder. Urinary continence recovery and perioperative complication will be analyzed.
OBJECTIVE: To create a formalized method for predicting papillary thyroid cancer recurrence after hemithyroidectomy based on preoperative data.
MATERIAL AND METHODS: At this stage of the study, we selected 101 patients with papillary thyroid cancer who underwent surgical treatment in 2017-2023. Recurrence was observed in in 47 patients. Fifty-four patients had no recurrence within 5 years after surgical treatment, i.e. these patients underwent surgery in 2017-2018. To find prediction rules, we used original classification method based on searching for subsets of variables and piecewise linear rules separating classes in pairs with subsequent voting of such rules to make a decision.
RESULTS: The exam was carried out using a training sample (101 cases) and sliding control method (10 tests on 10 random cases). On the training sample, sensitivity of predictive algorithm was 91%, specificity 78% and error rate 13%. The aggregated result of 10 trials using sliding control method revealed sensitivity of predictive algorithm 86%, specificity 75% and error rate 15%. This result is close to overall sample and confirms the effectiveness of this method for predicting recurrence.
CONCLUSION: The pilot experiments revealed the patterns in data for potential prediction of recurrence based on preoperative indicators. Further study of this problem may be valuable for decision-making and adjustments in the management of patients with papillary thyroid cancer.
PROBLEM TO BE SOLVED: To obtain the above composition containing a specific solid organic polysiloxane in combination with a lipid phase, having excellent light-scattering performance on the surface and aging stability and giving a delustered skin appearance over a long period. SOLUTION: An organic polysiloxane consisting of at least one partially crosslinked elastomer is used in combination with a lipid phase. The organic polysiloxane contains especially R2 SiO and RSiO1.5 units and arbitrary R3 SiO0.5 and/or SiO2 units (R is H, an alkyl, an aryl, etc.; the weight ratio of R2 SiO unit to RSiO0.5 unit is (1-30)/1). The hydrocarbon oil to be used in combination with the organic polysiloxane is preferably percelin oil and the silicone oil is preferably a straight-chain or cyclic polysiloxane exhibiting liquid or pasty state at normal temperature or their mixture. The elastomer is preferably used in the form of a gel.
Women at high risk for an AEP are define as sexually active, fertile women who are drinking more than 7 drinks per week and/or 5 or more drinks on any one day, and are noy using effective measures to prevent pregnancy. Participants will be recruited from community-based setting previously shown to have increased proportions of women at risk for AEP. Women in the intervention group (IPC) will receive 4 counselling sessions that include personal feedback on AEP risk behaviors drawn from baseline information,consequences of alcohol use in pregnancy, assessing readiness to change risk behaviors, pros and cons of risk drinking and unprotected intercourse, goal setting to reduce risk behaviors, and a consultation visit with a family planning provider to discuss appropriate choices for pregnancy prevention based on clinical assessment. Clients are counseled that there are two routes to reducing AEP risk, alcohol reduction or pregnancy prevention, with the ideal being both. Women in the control group (IO) will receive an informational brochure that addresses healthy lifestyle behaviors, including alcohol use, and a list of referral sources for health care treatment and alcohol abuse treatment. Both groups will be assessed at baseline using a full battery of measures that include alcohol and contraceptive use with follow-up measures at 3, 6, and 9 months after baseline.
Melatonin is chemically recognized as N-acetyl-5-methoxytryptamine. It is a compound occurring naturally in plants, microbes and animals. The circulating level of the melatonin hormone in animals shows interesting variations, by entertainment of variable biological functions in a daily cycle "circadian rhythm". Melatonin called hormone of night is secreted by the pineal gland, and its plasma levels concentration are 50 folds higher in night in comparison to daytime. A variety of peripheral cells play a role in production of melatonin such as epithelial cells, bone marrow cells, and lymphocytes. Though melatonin is a hormone, it does not act on a specific organ, it has several functions; stimulation of the synthesis of type I collagen fibers, regulation of the body temperature, sexual development, antioxidant scavenging and detoxifying free radicals thus inhibiting the process of bone resorption through interfering with the function of osteoclasts.
FIELD: medicine. SUBSTANCE: system has polymer material with drug introduced into it and represents itself as adhesive material sensitive to pressure. The polymer material has polyacrylate mixed with a second polymer material. The second polymer is selected from group consisting of polysiloxane and hydrocarbon polymer. Combination of polyacrylate and the second polymer has common solubility parameter. The solubility parameter modulates transcutaneous drug penetration velocity. The method includes stage of drug homogenization in polymer material and stage when the mixture is formed being adhesive system sensitive to pressure. EFFECT: selective inclusion of drugs in dermal systems; controlled drug penetration velocity. 69 cl, 12 dwg, 14 tbl
OBJECTIVE: To analyze the clinical features and genetic characteristics of a patient with Shwachman-Diamond syndrome (SDS) due to compound heterozygous variants of SBDS gene.
METHODS: A female child with SDS who was admitted to the Children's Hospital Affiliated to Zhengzhou University in February 2022 was selected as the study subject. Clinical data of the child was collected. Peripheral blood samples of the child and her elder sister and parents were collected and subjected to whole exome sequencing (WES). Candidate variant was verified by Sanger sequencing.
RESULTS: The child, a 1-year-and-1-month-old girl, had mainly manifested with diarrhea, hematochezia, growth retardation and malnutrition, along with increased transaminases and decreased neutrophils and hemoglobin. Anteroposterior X-ray of her left wrist indicated significantly delayed bone age. Colonoscopy revealed that her colorectal mucosa was erosive with oily food residues attached to the intestinal lumen. Genetic testing revealed that she has harbored c.258+2T>C and c.100A>G compound heterozygous variants of the SBDS gene. The c.258+2T>C variant has derived from her father and known to be pathogenic, whilst the other has derived from her mother. Based on the guidelines from the American College of Medical Genetics and Genomics, the c.100A>G variant was classified as likely pathogenic (PM1+PM2_Supporting+PM3+PM5+PP3).
CONCLUSION: The compound heterozygous variants of c.258+2T>C and c.100A>G probably underlay the SDS in this child. For children with refractory diarrhea, liver damage and growth retardation, SDS should be suspected, and genetic testing can facilitate the diagnosis and treatment.
The present invention relates to replication-competent adenovirus vectors which are specific for cells which allow an osteocalcin transcriptional regulatory sequence to function, such as prostate cancer cells, prostate stromal cells, vascular pericytes, proliferating cancer-associated osteoblasts, and prostate cancer and associated bone stromal cells which fail to express PSA or androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise an adenoviral gene under control of an osteocalcin transcriptional regulatory sequence. The gene can be, for example, a gene required for adenoviral replication. The viruses can also comprise at least one additional adenoviral gene under control of at least one additional tissue-specific transcriptional regulatory sequence. Thus, virus replication can be restricted to target cells exhibiting osteocalcin gene expression. Such replication-competent adenovirus vectors are useful in the treatment of prostate cancer, brain cancer, ovarian cancer, thyroid cancer, tumors, osteosarcoma, occular melanoma, lung cancer, or breast cancer.
The invention relates to a medicament for treating emphysema. The medicament for treating emphysema is prepared from the following ingredients, by weight, 13-16 parts of dandelion, 18-22 parts of haw, 17-21 parts of bletilla striata, 10-20 parts of anemarrhena, 10-25 parts of myrrh, 9-15 parts of Succus bambusae, 5-10 parts of radix peucedani, 12-15 parts of saltcake, 10-20 parts of borneol, 5-20 parts of Chinese gallnut, 3-9 parts of pepper and 10-30 parts of borneol. The invention also relates to a preparation method of oral and external-use dosage forms of the pharmaceutical composition. The medicament is low-cost and has definite therapeutic effects. Through reasonable compatibility of active ingredients and adjuvant ingredients and by mutual complementation and coordination of effects, the medicament has advantages of short treatment course, fast effectiveness, good curative effect and the like. As the medicament is prepared by compatibility of natural crude drugs, side effect, dependency or drug resistance will not be generated. The medicament is widely suitable for preventing, controlling and treating emphysema caused by various causes of diseases.
The invention includes a device and method. The device is a site directed neovascularization device. The device includes a biocompatible support. The device also includes a biological response modifier for inducing neovascularization. The biological response modifier is adsorbed to the biocompatible support. The method is for directing in vivo neovascularization. The method requires adsorbing a biological response modifier for inducing neovascularization onto a biocompatible support. The step of contacting a therapeutically effective amount of the adsorbed biological response modifier to at least one selected tissue then occurs. The method then involves directing neovascular cell growth at the contacted, selected tissue for a sufficient time to obtain a vascular structure. The method of this invention is useful for developing artificial organs and other tissues including nerves in an organism, and for sampling of cells and re-implantation after genetically altering the cells to produce a desired product.
Extremely low gestational age newborns (ELGANs) are born at or below 28 weeks of gestational age. Despite improved obstetric care, the incidence of preterm birth continues to rise in advanced countries. Preterm birth remains a major cause of infant mortality, and for infants who survive, neonatal seizures are a significant predictor of later neurologic morbidity. However, little is known about risk factors for neonatal seizures in ELGANs. Understanding the association between neonatal seizures and the development of other neurologic disorders is important given the increasing prevalence of ELGANs. Identifying risk factors that contribute to the development of neonatal seizures in ELGANs may offer insights into novel mechanisms of epileptogenesis in the developing brain and improvements in the prevention or treatment of seizures in preterm infants, including ELGANs. In this literature review, we outline the limitations of epidemiologic studies of neonatal seizures in ELGANs and discuss risk factors for neonatal seizures.