anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An increase in daytime anxiety has been reported for triazolam after as few as 10 days of continuous use. In some patients this may be a manifestation of interdose withdrawal. If increased daytime anxiety is observed during treatment, discontinuation of treatment may be advisable.

A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of benzodiazepine hypnotics including triazolam. Some of these changes may be characterized by decreased inhibition, e.g., aggressiveness and extroversion that seem excessive, similar to that seen with alcohol and other CNS depressants (e.g., sedative/hypnotics). Other kinds of behavioral changes have also been reported, for example, bizarre behavior, agitation, hallucinations, depersonalization. In primarily depressed patients, the worsening of depression, including suicidal thinking, has been reported in association with the use of benzodiazepines [see Warnings and Precautions (5.9)].

Some adverse reactions reported in association with the use of triazolam such as drowsiness, dizziness, light-headedness, and amnesia appear to be dose related. More serious behavioral phenomena such as confusion, bizarre or abnormal behavior, agitation, and hallucinations may also be dose related, but this evidence is inconclusive. Therapy should be initiated at the lowest effective dose [see Dosage and Administration ( 2.1) ].

It can rarely be determined with certainty whether a particular instance of the abnormal behaviors listed above is drug induced, spontaneous in origin, or a result of an underlying psychiatric or physical disorder. Nonetheless, the emergence of any new behavioral sign or symptom of concern requires careful and immediate evaluation.

Anterograde amnesia of varying severity and paradoxical reactions have been reported following recommended dosages of triazolam. Data from several sources suggest that anterograde amnesia may occur at a higher rate with triazolam than with other benzodiazepine hypnotics. Because triazolam can cause drowsiness and a decreased level of consciousness, patients, particularly the elderly, are at higher risk of falls.

Cases of "traveler’s amnesia" have been reported by individuals who have taken triazolam to induce sleep while traveling, such as during an airplane flight. In some of these cases, insufficient time was allowed for the sleep period prior to awakening and before beginning activity. Also, the concomitant use of alcohol may have been a factor in some cases.
This study has two main parts. The first part is to verify and optimize the clinical application effect of the existing prediction model. The clinical data of the acute ischemic stroke intravenous thrombolytic population is collected retrospectively, mainly including baseline indicators and 7 days after thrombolysis Internal bleeding, based on the existing prediction models (HAT, SIT-sICH, THRIVE), calculate the prediction probability, and compare it with the actual bleeding situation, evaluate the clinical application effect of the prediction model, use ROC curve, calibration curve, sensitivity and Evaluation of indicators such as specificity. Using retrospective data, using multivariate logistic regression to analyze the predictive value of baseline clinical indicators, screening risk factors, and optimizing the HAT, SIT-sICH, and THRIVE prediction models. The logistic regression model is used to construct an improved HT prediction model based on the AIC principle; the method of model comparison is used to combine the clinical significance of the indicators to complete the construction of the prediction model. The second part is to evaluate the clinical application effect of the improved prediction model, and prospectively collect clinical data of AIS patients undergoing intravenous thrombolysis in Shenzhen Second People's Hospital, Shenzhen Longhua District People's Hospital, including general demographic data and laboratory tests Baseline indicators such as imaging examinations, bleeding within 7 days after thrombolysis, etc., were used to verify the improved HT prediction model using ROC curve, calibration curve, sensitivity and specificity, and external verification was performed to evaluate the prediction effect of the model.
This is a digital information system that any individual may join through a terminal with Internet access, and its purpose is to provide the participating user with a special service in the event of an accident and in the event the user has to receive emergency assistance; this service includes access to his or her most important emergency data in order to be taken into consideration by the intervening professional assistant, who may also inform the assisted user's contacts (family members) regarding the accident. Includes a combination of resources that are functionally and mutually linked, which can be defined as follows: • a QR Code specific to each user who joins the invented system, which constitutes the link through which it is possible to enter the Central Administration; • a User (US) is a carrier of a specific QR Code (properly processed and obtained by accessing Central Administration); • a Central Administration, which constitutes the system's server and database that stores the users' medical and contact information, and includes: • an Emergency assistant, conceived to access the server by reading the users QR code when providing assistance to a user (US) in an emergency situation. The QR code is obtained by entering Central Administration through a communication device (computers, tablets, cell phones, etc.) with Internet access. Likewise, the Central Administration uses a System Administrator enabled to set parameters, control requirements, and create new types of emergency data, and a Users Administrator enabled to create accounts with institutions who are authorized to provide emergency care services. The Emergency Service Worker could be any non-professional assistant who access the server only to take and transmit contact and basic medical data, or else any professional assistant who resorts to the server and has the capacity to access important diagnostic medical data in order to guide emergency treatment.
The ubiquitination-mediated protein degradation exerts a vital role in the progression of multiple tumors. NEDD4L, which belongs to the E3 ubiquitin ligase NEDD4 family, is related to tumor genesis, metastasis and drug resistance. However, the anti-tumor role of NEDD4L in esophageal carcinoma, and the potential specific recognition substrate remain unclear. Based on public esophageal carcinoma database and clinical sample data, it was discovered in this study that the expression of NEDD4L in esophageal carcinoma was apparently lower than that in atypical hyperplastic esophageal tissue and esophageal squamous epithelium. Besides, patients with high expression of NEDD4L in esophageal carcinoma tissue had longer progression-free survival than those with low expression. Experiments in vivo and in vitro also verified that NEDD4L suppressed the growth and metastasis of esophageal carcinoma. Based on co-immunoprecipitation and proteome analysis, the NEDD4L ubiquitination-degraded protein ITGB4 was obtained. In terms of the mechanism, the HECT domain of NEDD4L specifically bound to the Galx-β domain of ITGB4, which modified the K915 site of ITGB4 in an ubiquitination manner, and promoted the ubiquitination degradation of ITGB4, thus suppressing the malignant phenotype of esophageal carcinoma.
Endoplasmic reticulum stress has been found to be associated with the genetic disease tuberous sclerosis. Tuberous sclerosis is cause by defects in the two genes, TSC1 and TSC2. Agents that modulate ER stress may be used to treat tuberous sclerosis and other hamartomatous diseases. In particular, 4-phenyl butyric acid (PBA) has been shown to reduce ER stress is TSC-deficient cells. Other compounds useful in reducing ER stress are chemical chaperones such as trimethylamine N-oxide arid glycerol may also be useful in treating tuberous sclerosis. The present invention provides methods of treating a subject suffering from tuberous sclerosis using ER stress reducers such as PBA, TUDCA, UDCA, and TMAO. Methods of screening for ER stress reducers by identifying agents that reduce levels of ER stress markers in TSC-deficient cells are also provided. These agents may find use in methods and pharmaceutical compositions for treating tuberous sclerosis.
FIELD: medicine. ^ SUBSTANCE: group of inventions relates to medicine. Device, moving above patient with bright white light, photographs, registers and transmits onto display screen total area of wound surface of burns, including numerical ratio in percent, with possibility of enlarging the most affected sites, for logging and monitoring dynamics of wound surface therapy. Boundaries of affection degrees are determined under intensive blue colour. Depending on affection degree specialist selects therapy for each section. Depth of skin and organ affection is also determined by device by means of ultrasonic scanner and in case of necessity depth of burn affection is displayed on monitor in two-dimensional image and snapshots for comparative dynamics of recovery are made. After determining area and degree of affection fine-aerosol of antiseptic preparation is dispersed for quick reduction of wound surface temperature and prevention of infectious complications. After application of antiseptic preparation above entire wound surface performed is phototherapy with blue spectrum with simultaneous air ventilation for reducing pain, lowing down temperature of wound surface, recovery of its microcirculation and air ablation of necrotic tissues. After required surgery medication with film-forming suspension is applied by device in form of fine aerosol, which again leads to reduction of burn surface temperature and prevents "greenhouse effect" of wound. After application of medication device switches on blue irradiators, spectrum of which reduces pain, restores microcirculation, activates medication and increases cell metabolism, simultaneous switching on of ultrasonic transmitter increases permeability of pores and membranes of skin and epithelium cells for medications. After the end of procedure air ventilation is switched on. ^ EFFECT: blue spectrum will make it possible to accelerate process of wound surface healing and will exclude secondary infection, ensure cytoprotective effect, activate exchange processes, improve blood supply of tissues at the level of microcirculation. ^ 5 cl, 3 dwg
The present disclosure refers to topical pharmaceutical bases that possess antiviral properties. Further, these topical pharmaceutical bases are employed for preventing a patient to be infected by viral diseases. The topical pharmaceutical bases include Amazonian oils and resins, such as pracaxi oil and breu-branco resin. The synergistic effect of pracaxi oil combined with breu-branco resin results in a highly effective antiviral treatment. Suitable active pharmaceutical ingredients (APIs) can be incorporated to the topical pharmaceutical bases to formulate topical pharmaceutical compositions, which improve antiviral effects. The synergistic effect provided by the combination of pracaxi oil and breu-branco resin enables lower dosage requirements of the associated APIs when topical pharmaceutical compositions are employed for preventing viral diseases.
Research has confirmed that a food's glycemic effect cannot be accurately predicted from the type and amount of carbohydrates it contains, as the rate at which the carbohydrates is digested and released into the bloodstream is influenced by many factors such as the food's physical form, its fat, protein and fibre content, and the chemical structure of its carbohydrates. For these reasons, it is possible to produce food from the same group with different effects on blood glucose. Consumption of low GI food has shown to improve glycemic control, lipid profile and reduce systemic inflammation. However, there are few dietary intervention studies attempting to change the GI of food by changing the staple carbohydrates. In this study, microfluidics was applied in the creation of low-GI food gel made from non-traditional ingredients like alginate and soy protein isolate. This method is previously tested to produce lower glycaemic response than normal noodle and pasta. With noodles being one of the staples to many Singaporeans, food gels formed using functional ingredients derived from food sources offer a lower GI alternative to the conventional noodle and pasta without affecting the people dietary preference.
Participants will receive RO7445482 (Dose 2) in addition to their background NUC therapy for the 48-week treatment period. RO7020531 (150 mg QOD) will be administered during Weeks 13-24 and Weeks 37-48 (i.e., 2 treatment cycles of 12 weeks' duration each and 42 doses of RO7020531 for each cycle). At the end of the treatment period, participants will continue NUC treatment during the follow-up unless the NUC discontinuation criteria have been met.
PURPOSE: To describe a case of endogenous endophthalmitis as a complication from hair transplantation.
METHODS: Case report of a 53-year-old man with a history of recent hair transplantation.
RESULTS: The patient presented with a febrile illness and blurry vision 1 week after hair transplantation. Infectious workup included blood cultures positive for methicillin-resistant Staphylococcus aureus, and he was treated with IV antibiotics. Initial ocular examination demonstrated 20/30 and hand motions in the right and left eyes, respectively, with significant vitritis. He underwent vitreous tap and injections of vancomycin and dexamethasone in both eyes and removal of purulent staple from the site of recently transplanted hair. His ocular and systemic symptoms improved. Approximately 3 months after initial clearing of the initial infection he had recurrence of bacteremia that prompted repeat intravitreal and systemic antibiotics. His vision returned to baseline with mild residual optic nerve pallor and atrophic retinal changes in the left eye.
CONCLUSION: Hair transplantation is associated with minimal systemic complications, but in rare cases, sepsis is possible and can result in intraocular seeding causing endophthalmitis. MRSA endogenous endophthalmitis frequently results in negative vitreous taps and treatment outcomes in the literature have been shown to vary widely including a return to baseline vision as in the described case.
Part B will include patients with relapsed or refractory small-cell lung cancer (SCLC). Patients will receive AZD2811 monotherapy at the recommended Phase 2 dose (RP2D).
Group 1 will receive oxygen (99%) in Phase 1, and room air (placebo) in Phase 2. Each phase will consist of 2 experiments. In Phase 1, the first experiment will test skin sensation using von Frey Hairs, while the second experiment will test a cutaneous reflex. In Phase 2, the first experiment will test the cutaneous reflex, while the second experiment will test skin sensation with von Frey Hairs. Both high oxygen and room air will be delivered through a face mask. The flow rate will be 10 litres/min for a 2-min period. Participants and experimenters will be blinded to the intervention. Measures will be taken before and after each exposure. In this way, each participant will be involved in four experimental sessions with a minimum of 2-week intervals between every testing session. Each experimental session will take approximately 1.5 to 2 hours. A total duration of involvement in the study is a minimum of 7 weeks.
The invention belongs to the field of ethnic medicines and discloses a Yao medicine composition with a function of tranquilizing the mind by nourishing the heart and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 2-20 parts of albizia flower, 1-10 parts of cassia bark, 3-30 parts of tuber fleeceflower stem, 2-20 parts of salvia miltiorrhiza, 1-10 parts of dried longan pulp, 2-20 parts of ganoderma lucidum, 2-20 parts of polygala aureocauda dunn, 3-30 parts of spina date seed, 2-20 parts of prepared polygala tenuifolia, 1-10 parts of lotus seeds, 4-40 parts of Huai wheat, 3-30 parts of liquorice and 2-20 parts of Chinese dates. The dosage form of the composition is powder or tea bags. The preparation method comprises the processes of grinding, baking and sterilizing the raw medicines, thus preparing the powder or tea bags. Clinical tests show that the Yao medicine composition has the functions of soothing the liver to resolve depression, tranquilizing the mind by nourishing the heart, nourishing qi to invigorate the spleen, clearing away the heart fire to relieve restlessness and replenishing qi and nourishing blood. The Yao medicine composition takes effect quickly, has stable curative effects, does not have toxic or side effect and is a health protection medicine with the function of tranquilizing the mind by nourishing the heart.
HIT is an immune response to heparin that can result in thrombogenic thrombocytopenia. It is often a difficult diagnosis to make, and its diagnosis is dependent upon both clinical and serologic criteria. Due to this ambiguity, increased testing and treatment may occur until serologic test results return. Recently, scoring tools have been developed to assist with the diagnosis of this disease. However, these scoring tools have yet to be validated. Thus, we plan to conduct a prospective, observational study to validate two scoring tools, the 4Ts and the Chong scale, in the diagnosis of HIT.

In order to validate these scoring tools, two physicians will independently score the 4Ts and the Chong scale for all patients suspected of having HIT. These patients will be identified if a physician has ordered HIT antibody testing using the enzyme immunoassay (EIA) method. Confirmatory testing with a serotonin release assay (SRA) will also be performed.
In Part 1, participants receive placebo IV as post-surgery therapy Q3W. During Part 2, participants with documented recurrence who received placebo in Part 1 may receive optional treatment with pembrolizumab Q3W for up to 2 years or disease progression.
PURPOSE: A manufacturing method of a chitin ester derivative is provided to do esterification directly by using carboxylic acid derivatives and trifluoroacetic anhydride, thereby manufacturing chitin ester derivatives economically and massively. CONSTITUTION: A chitin ester derivative is in chemical formula 1. In chemical formula 1, R is cyclopropyl, cyclobutyl, and cyclopentyl or the cyclohexyl. A manufacturing method of the chitin ester derivative comprises a step of reacting chitin with catalyst and cycloalkyl carboxylic acid. The catalyst is trifluoro acetic anhydride or N,N-dicyclohexylcarbodiimide. The cycloalkyl carboxylic acid is cyclopropane carboxylic acid, cyclobutane carboxylic acid, cyclopentane carboxylic acid or cyclohexane carboxylic acid.
Prodn. of a pumice-stone substitute from natural clay involves: (a) mixing 100 wt. parts natural earthenware clay with 28-30 wt. parts fibrous organic material and 30-40 wt. parts lime-free water; (b) moulding under pressure; (c) drying; and (d) firing at about 1000 deg C in an oxidising atmosphere. Also claimed is a pumice-stone substitute product obtained by the above process. Further claimed are: (i) a process for prodn. of a pumice-stone substitute having lathering properties by immersing the above product in a tank contg. a liq. lathering base and subjecting to opt. heating and to alternate pressure redn. and pressurisation operations; (ii) a pumice-stone substitute product obtained by process (i); and (iii) a device for carrying out the impregnation stage of process (i).
Disclosed are a slow release pasireotide microsphere and a preparation method thereof. The microsphere is prepared using pasireotide as an active ingredient, and a microsphere support polymer, a protecting agent, a surfactant and a suspending agent. The microsphere support polymer is selected from polylactic-co-glycolic acids (PLGA). The suspending agent is selected from one or a combination of any two or more of tragacanth, gum arabic, carbomer and sodium alginate. The preparation method of the microsphere is a multiple emulsion method. Addition of the suspending agent allows for a release time of the pasireotide microsphere of up to 28 days.
Weekly promotora-led group sessions on physical activity (16 weeks) and followed by monthly telephone counseling and newsletters during the 24 week maintenance period. Promotoras will also implement environmental change strategies to increase the number of PA program offerings available to study participants.
Participants in the TODOS Intervention Group will receive the intervention "Nowhi Isdza bit Nadagoldi": Telling Our Daughters Our Story. They will receive 11 intervention sessions of 60-90 minutes over 11 weeks.
An injectable or implantable medical device having orifice(s) on the surface that release an active agent with zero-order release kinetics is described herein. The device is a hollow matrix of any size or shape, which can be made from both metal and non-metal surfaces. The device comprises of a reservoir capable of releasing at least one therapeutic, diagnostic, or prophylactic agent via the orifices to the desired anatomical site. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time. The composition provides zero-order kinetics, in part, because the diffusion rate of the drug from the device is slow which enables sink conditions. Hence, no back transfer or build up of drug occurs at anytime. Polymers are not required for controlled release.
The invention relates to a cool type chloranthus spicatus (tunb.) maki-no hand-washing solution. The cool type chloranthus spicatus (tunb.) maki-no hand-washing solution comprises the following components in parts by weight: 5-10 parts of stearic acid, 1-8 parts of glycol stearate, 1-2 parts of wire drawing powder, 10-20 parts of a chloranthus spicatus (tunb.) maki-no extract solution, 5-10 parts of a sulfur soap solution, 10-20 parts of a camphortree leaf extract solution, 5-10 parts of peppermint oil and the balance of deionized water. The cool type chloranthus spicatus (tunb.) maki-no hand-washing solution provided by the invention has chloranthus spicatus (tunb.) maki-no fragrance, the camphortree leaf extract solution and the sulfur soap solution are matched for sterilization, and the cool type chloranthus spicatus (tunb.) maki-no hand-washing solution further has a certain prevention and adjuvant treatment effect on skin diseases on the arms and further realizes a cool effect on the arms after being used for washing.
Four periods separated by a wash out lasting up to 3 days at maximum. At each period, application of one product (twice). Duration of treatment period: From 4 to 13 days.