anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to the technical field of biological medicines, in particular to a compound, a nitric oxide donor prodrug compound, and a preparation method and application thereof. The compound has a structure shown in a formula I-1, is used for preparing a nitric oxide donor prodrug compound, and has a structure shown in a formula I. The preparation method of the compound comprises the following steps: step c): the compound of formula I-1 is prepared by condensing the compound of formula I-2 with pyrrolidinyl diazodiol sodium salt. The preparation method of the nitric oxide donor prodrug compound comprises the following steps: step d): the compound of formula I is prepared by deacetylating the compound of formula I-1. The nitric oxide donor prodrug compound can be used for controllably releasing nitric oxide under the catalysis of endo-cellulase and can be used for controllably releasing nitric oxide under the natural bio-orthogonal catalysis of endo-cellulase Cel5A-h 38. Therefore, the medicine can be used for preparing the medicine capable of releasing nitric oxide in a controlled manner by utilizing the characteristic of releasing nitric oxide in a controlled manner according to requirements.
All infants enrolled in the study will be monitored with cerebral near-infrared spectroscopy (NIRS monitoring) to measure cerebral oxygenation levels in the first 96 hours of life. Mean arterial blood pressure will simultaneously be monitored.
This group will consist of pregnant women who will receive a single dose of Boostrix™ at 27-36 weeks (i.e. completed 27 weeks until 36 weeks) of gestation (Visit 1) and will receive a dose of the placebo post-delivery (within 72 hours).
To provide applications of biotransformed bear bile powder in the preparation of anti-inflammatory drugs.SOLUTION: The present invention provides applications of biotransformed bear bile powder in the preparation of anti-inflammatory drugs. In the present invention, a comparative study was conducted on the anti-inflammatory drug efficacy between biotransformed bear bile powder and natural bear bile powder. Experimental studies of biotransformed bear bile powder and natural bear bile powder against a rat inflammation model induced by carrageenan, and a study of the effect of biotransformed bear bile powder on LPS-induced murine pneumonia were conducted. According to the experimental results, a biotransformed bear bile powder-administered group remarkably reduced the degree of plantar swelling in a rat induced by carrageenan. The effect is not lower than that of natural bear bile powder. It is supported that since both biotransformed bear bile powder and natural bear bile powder can remarkably reduce the levels of inflammatory factors IL-6 and TNF-α in the lungs and serum, biotransformed bear bile powder can be applied to the preparation of anti-inflammatory drugs.SELECTED DRAWING: Figure 1
Tolazamide is rapidly and well absorbed from the gastrointestinal tract. Peak serum concentrations occur at three to four hours following a single oral dose of the drug. The average biological half-life of the drug is seven hours. The drug does not continue to accumulate in the blood after the first four to six doses are administered. A steady or equilibrium state is reached during which the peak and nadir values do not change from day to day after the fourth to sixth doses.

Tolazamide is metabolized to five major metabolites ranging in hypoglycemic activity from 0-70%. They are excreted principally in the urine. Following a single oral dose of tritiated tolazamide, 85% of the dose was excreted in the urine and 7% in the feces over a five-day period. Most of the urinary excretion of the drug occurred within the first 24 hours post administration.

When normal fasting nondiabetic subjects are given a single 500 mg dose of tolazamide orally, a hypoglycemic effect can be noted within 20 minutes after ingestion with a peak hypoglycemic effect occurring in two to four hours. Following a single oral dose of 500 mg tolazamide, a statistically significant hypoglycemic effect was demonstrated in fasted nondiabetic subjects 20 hours after administration. With fasting diabetic patients, the peak hypoglycemic effect occurs at four to six hours. The duration of maximal hypoglycemic effect in fed diabetic patients is about ten hours, with the onset occurring at four to six hours and with the blood glucose levels beginning to rise at l4 to16 hours. Single dose potency of tolazamide in normal subjects has been shown to be 6.7 times that of tolbutamide on a milligram basis. Clinical experience in diabetic patients has demonstrated tolazamide to be approximately five times more potent than tolbutamide on a milligram basis, and approximately equivalent in milligram potency to chlorpropamide.
The placebo will be made of cellulose and a small amount of fish powder to maintain the double-blind in odor and taste. The supplementation in n-3 PUFA in the placebo group may be considered as negligible. Placebo will be administered as indistinguishable capsules, identical to the active product.
A system and method to obtain activity data for an activity of a user, the activity data corresponding to multiple parameters. A set of threshold criteria that corresponds to a multi-parameter activity zone is retrieved, where the set of threshold criteria includes an effort threshold criteria related to a heart rate of the user. An effort of the user is determined based on the activity data. A resistance experienced by the user is determined, where the resistance includes a measure representing at least one of stride rate, step rate, steps, or cadence. A posture of the user is determined. Based on the set of threshold criteria corresponding to the multi-parameter activity zone, an instance of the activity is classified as an activity type based on the resistance experienced by the user, the effort of the user, and the posture of the user.
Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin. Fibrogenesis is a highly orchestrated process defined by sequences of cellular response and molecular signals mechanisms underlying the disease. In pathophysiologic conditions associated with organ fibrosis, a variety of injurious stimuli such as metabolic disorders, epigenetic changes, and aging may induce the progression of fibrosis. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. In this review, we outline our current understanding of common principles of fibrogenic mechanisms and the functional role of SIRT3/6 in aging-related fibrosis. In addition, sequences of novel protective strategies have been identified directly or indirectly according to these mechanisms. Here, we highlight the role and biological function of SIRT3/6 focus on aging fibrosis, as well as their inhibitors and activators as novel preventative or therapeutic interventions for aging-related tissue fibrosis.
FIELD: pharmaceutical industry. SUBSTANCE: invention relates to a polyol composition used for production of tablets. Composition is prepared by combined spraying drying or combined granulation in the fluidized layer. Composition consists of at least two polyols and, possibly, one binding agent. Composition has at least one nonhygroscopic polyol taken in the amount above 80 wt.-% of total polyol content. Nonhygroscopic polyol is taken among the group including mannitol, lactite, isomaltite, xylitol and erythritol. Polyol composition shows the more low hygroscopicity as compared with that of sorbitol and provides high hardness of tablets and pressed articles and smooth surface. EFFECT: improved properties of composition. 12 cl, 19 dwg
Among all age groups, knowledge of reproductive health can prevent unplanned pregnancy and STIs. The study assessed the status of reproductive health knowledge among secondary school girls in Limpopo Province, South Africa. A cross-sectional descriptive study design was conducted among secondary school girls between the ages of 14 and 19. A total of three hundred and forty (N=340) eligible learners were selected using stratified random sampling method. A self-administered questionnaire was used for data collection and data was analysed using Statistical Package for Social Sciences (SPSS) version 25. All ethical considerations were ensured throughout the study. About 184(56%) of the respondents were aged between 14 and 16 years, and 59% were grade nine and ten. The majority (72%; n=239) of the respondents stayed in rural areas and attended public schools (83%;n=274). Half (51%) of the study respondents had no idea about menstruation. Nine percent (24) of the respondents mentioned ICUD as a method of contraception. HIV/AIDS was the most common STI infection known by respondents at 52%. Oral and injectable contraceptives 72(35%) were cited as the most known methods to prevent unplanned pregnancies. The study found that respondents exposed little or lack of knowledge about reproductive health. Therefore, the Department of Education must carry out reproductive education among girls to promote reproductive health. Parents should be encouraged to explain reproductive health issues to their girl child.
Part A: Ascending doses of AZD5363 administered orally, every day to define the maximum tolerated dose. Part B: Dose expansion phase, at the defined maximum tolerated dose or recommended dose from Part A.
BACKGROUND: Frailty is associated with reduced intrinsic capacity (IC). However, studies evaluating longitudinal transitions between IC and frailty are limited. We conducted longitudinal analyses to investigate the association between intrinsic capacity (IC) and frailty transitions among community-dwelling older adults in Korea.
METHODS: A total of 2,345 older adults who completed baseline and two-year follow-up surveys were selected from the Korean Frailty and Aging Cohort Study. IC was measured in five domains: locomotion, vitality, cognition, psychology, and sensory function. Frailty was defined using the Fried frailty phenotype. Transitions in IC and frailty were assessed. Logistic regression analysis was used to analyze the association between baseline IC, IC transitions, and frailty transitions.
RESULTS: During the two-year follow-up, 17.8 % of participants improved, 20.4 % worsened, and 61.8 % maintained the same frailty status. Low IC (odds ratio [OR]=1.93; 95 % confidence interval [CI]=1.42-2.61) significantly predicted remaining frail or worsening frailty. Worsened IC increased the risk of remaining frail or worsening frailty, whereas improved IC decreased this risk. Among the IC domains, the onset of new locomotion (OR=3.33; 95 % CI=2.39-4.64), vitality (OR=2.12; 95 % CI=1.55-2.91), and psychological (OR=3.61; 95 % CI=2.64-4.92) impairment predicted remaining frail or worsening frailty.
CONCLUSIONS: Low and worsened IC were associated with an increased risk of remaining frail or worsening frailty over two years. These findings indicate that changes in IC can predict frailty transitions, thereby emphasizing the importance of enhancing IC in preventing frailty progression.
Patient diagnosis form with CHB and related scales (Patient Diagnosis Form with Chronic Hepatitis B, Medication Adherence Report Scale-5), Medication Adherence Report Scale (MedTake Test), Chronic Liver Disease Quality of Life Scale 2.0" (Liver Disease Symptom Index 2.0 (LDSI 2.0), Health-Related Quality of Life Scale SF-12" (12 Item Short Form Health Survey) (Short Form 12 - SF 12), Patient Learning Needs Scale will be applied before the intervention. The training will be in two modules and two different sessions. The effectiveness of the training will be evaluated by re-applying the scales 12 weeks and 24 weeks after the training.
Participants in the Behavioral: Counseling arm will receive two individual sessions with a registered dietitian and monthly newsletters that focus on existing community resources.All participants will be seen for assessment visits as baseline, 6, and 12 months. Some participants will also complete 18 and 24 month visits, depending on the date of randomization.
Patients with a new diagnosis of rheumatoid arthritis and indication for initiating DMARD treatment with a bridging of oral glucocorticoid treatment. Women should be premenopausal and men younger than 50 years.
The invention discloses a drug for treating acute or chronic pulpitis and periodontitis. The drug is a pharmaceutical composition prepared through a certain process by using pure natural plants, minerals and other materials. The prescription is unique, moderate and synergetic, and has an excellent function of dispelling the orifices to open depression, clearing heat, expelling wind and eliminating cold to stop pain. Therefore, the pain is relieved as soon as the drug takes effect, the drug gets effects instantly and is safe and reliable without any toxic or side effect. Patients are surprised and highly praise the drug after using the drug. Not only is the curative effect good, but also the pain does not reoccur. And moreover, the drug has the characteristics that the raw materials come from a variety of sources, the cost is low, the preparation is simple, and the three wastes are not produced in the production.
People who suffer from pathological worry report that they worry to an excessive degree and that they find it very difficult to control their worry. Deficits in attention control may help to explain why people who worry pathologically find it difficult to shift their attention away from their worry, and back to the task at hand. The Attention Training Technique (ATT; Wells, 1990) was developed to train attentional control, so that individuals could learn to shift the focus of their attention away from maladaptive cognitive processes such as worry. Despite being recommended for use in populations that suffer from excessive worry, there is a dearth of research examining the effects of ATT in such a population. The study aims to examine the immediate (during the intervention) and short-term (right after finishing the intervention) effects of listening to the ATT, compared to the control recording, on attention, worry, and other cognitive processes. This will be the first study to our knowledge to examine the effects of 1 week of daily ATT practice in a sample of people who suffer from chronic worry, and will provide important information for optimizing the treatment of worry in this population.
Lysyl oxidases (LOX(L)) are enzymes that catalyze the formation of cross-links in collagen and elastin fibers during physiologic calcification of bone. However, it remains unknown whether they may promote pathologic calcification of articular cartilage, an important hallmark of debilitating arthropathies. Here, we have studied the possible roles of LOX(L) in cartilage calcification, related and not related to their cross-linking activity. We first demonstrated that inhibition of LOX(L) by β-aminoproprionitrile (BAPN) significantly reduced calcification in murine and human chondrocytes, and in joint of meniscectomized mice. These BAPN's effects on calcification were accounted for by different LOX(L) roles. Firstly, reduced LOX(L)-mediated extracellular matrix cross-links downregulated Anx5, Pit1 and Pit2 calcification genes. Secondly, BAPN reduced collagen fibrotic markers Col1 and Col3. Additionally, LOX(L) inhibition blocked chondrocytes hypertrophic differentiation (Runx2 and COL10), pro-inflammatory IL-6 release and reactive oxygen species (ROS) production, all triggers of chondrocyte calcification. Through unbiased transcriptomic analysis we confirmed a positive correlation between LOX(L) genes and genes for calcification, hypertrophy and extracellular matrix catabolism. This association was conserved throughout species (mouse, human) and tissues that can undergo pathologic calcification (kidney, arteries, skin). Overall, LOX(L) play a critical role in the process of chondrocyte calcification and may be therapeutic targets to treat cartilage calcification in arthropathies.
A method for treating pyoseptical diseases in the children comprises the administration of the freshly frozen blood plasma of the same group, the parenteral administration of antibiotics, and detoxifying therapy. The freshly frozen blood plasma containing the high titer of anti-endotoxin antibodies is administered intravenously dropwise in the volume of 10 mL per of body mass. The number of the courses of the treatment depends on the stage of the septic process. In the case of the systemic inflammatory response, two courses with 3-day interval are used. In the case of infection – two courses with 1-2-day intervals. In the case of sepsis – 3 courses with 1-2-day intervals. In the cases of the severe sepsis and septic shock – 4-5 courses daily.
The invention discloses providencia vermicola and application of providencia vermicola in preparing antibacterial drugs. The preservation number of providencia vermicola No. 22 is CCTCC No. M2013696. The providencia vermicola No. 22 has antagonism, so that the providencia vermicola No. 22 can be used for preparing preparation for preventing and controlling vibrio alginolyticus or preparing assistant hemolysis vibrio preparation; the preparation for preventing and controlling vibrio alginolyticus or the assistant hemolysis vibrio preparation can be used for beneficial microbial preparation to replace chemical medicine, improves water quality, and eliminates vibrio alginolyticus or assistant hemolysis vibrio in an aquatic product cultivation system, so that damage to aquatic product cultivation objects from the vibrio alginolyticus or assistant hemolysis vibrio is prevented, the development of the aquatic product cultivation industry is promoted, aquatic products are prevented from carrying the vibrio alginolyticus or assistant hemolysis vibrio, and health and safety of human beings are ensured.
Implants with platform switching (Astra Tech Implant System EV) will be placed and cover screws will be inserted. Acellular dermal matrix, thick 1 x 4 cm will be used for vertical soft tissue augmentation.
BACKGROUND: Patients with central lines face an increased risk of developing bacteremia. Preventing late-onset catheter-related infections relies on implementing various measures during manipulations of the catheter hub of central lines (e.g., during connections, disconnections, blood withdrawals, pulsed rinses, or injections performed at the first connection after the central catheter). French guidelines include, among these measures, the requirement to put on sterile gloves immediately before proximal manipulation to help prevent contamination of the catheter hub during preparation. To our knowledge, no study has reported compliance with wearing sterile gloves during these manipulations, nor the impact of not wearing sterile gloves on the cleanliness of the fingers of healthcare workers (HCWs) just before manipulating the connectors.
METHODS: We conducted a two-part study to assess compliance with sterile gloving and to provide direct microbiological evidence of bacterial contamination on HCWs' hands immediately before the manipulation of central lines when sterile gloving is not used. First, the use of sterile gloves was observed during proximal manipulations of central lines using a standardized grid. Second, we examined the microbial flora present on the fingers of each observed HCW just before proximal manipulation.
RESULTS: A total of 260 HCWs from 35 healthcare institutions were observed during proximal manipulation. The HCWs were distributed into three groups: 188 used sterile gloves (72%), 23 used nonsterile gloves (9%), and 49 did not wear gloves (19%). The swabbing of the fingertips revealed microbial cultures from 72 samples (28%). A total of 97 microorganisms were identified, all of which are well-recognized agents responsible for catheter-related bacteremia, predominantly coagulase-negative staphylococci (n = 36) and Bacillus sp. (n = 31). Fingertip contamination was lower for HCWs wearing sterile gloves (27/188; 14%) than for those wearing nonsterile gloves (12/23; 52%) or not wearing gloves (33/49; 67%) (p < 0.001). The contaminants were similar across the three groups.
CONCLUSIONS: Our data support the positive impact of sterile gloving in ensuring clean fingertips during proximal manipulation of central lines, a key measure in preventing late-onset catheter-related bacteremia. The contamination of sterile gloves in one out of seven HCWs highlights the need for a clean care environment and minimal contact with the patient's skin and surroundings during proximal manipulation.
A cohort of control breast tissue will be obtained from 20 patients undergoing benign surgical breast procedures. For those control patients having reduction mammoplasties the excised tissue will be core biopsied but patients having other types of benign surgery will have an extra core biopsy taken from breast tissue surrounding the lesion being excised.
PCT No. PCT/US95/05374 Sec. 371 Date Dec. 8, 1995 Sec. 102(e) Date Dec. 8, 1995 PCT Filed May 12, 1994 PCT Pub. No. WO94/26284 PCT Pub. Date Nov. 24, 1994This invention provides a method of using modified human cytotoxic TALL-104 cell line, which is characterized by activity against tumor cells. More particularly, the method comprises treating bone marrow cells of an immunosuppressed mammalian patient with the modified TALL-104 cell line and reinjecting the treated bone marrow into the patient, as a treatment of hematological malignancies. Also provided are effective and safe methods of use of the modified cells in the manufacture of a veterinary composition for adoptive therapy of canine lymphoma and feline leukemias.
Chromosomal microarrays (CMA) incorporate single nucleotide polymorphisms to enable the detection of regions of homozygosity (ROH). Here, we retrospectively analyzed 6288 prenatal cases who performed CMA to explored the clinical implications of large ROH in prenatal diagnosis. We analyzed cases with ROH larger than 10 megabases and reviewed the ultrasound findings; karyotype results and pregnancy follow-up data. Cases with possible imprinting disorders were assessed by methylation-specific multiplex ligation-dependent probe amplification. In total, we identified 50 cases with large ROH and chromosomes 1 and 2 were the most affected. About 59.18% of the ROH cases had ultrasound abnormalities, with the most common findings being ultrasound soft-marker abnormalities. There were seven fetuses had ROH which covered almost the entire chromosome and four had terminal ROH that involved almost the entire long arm of the chromosomes, which indicated uniparental disomy (UPD), of which 70% showed abnormal ultrasound findings. Ten cases with multiple ROH on different chromosomes indicated the third to fifth degree of consanguinity. In this study, we highlighted the clinical relevance of large ROH related to UPD. The analysis of ROH allowed us to gain further understanding of complex cytogenetic and disease mechanisms in prenatal diagnosis.