anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to preparation process and production method for a Magnolia Officinalis Seven-Ingredient Decoction preparation in an integrated new dosage form, comprising raw materials of effective component including (by weight parts) Magnolia officinalis 24, Radix Glycyrrhizae 9, Radix Et Rhizoma Rhei 9, Ziziphus jujuba (Fructus Jujubae) 10, Fructus Aurantii Immaturus (Citrus aurantium and/or Citrus sinensis) 5, Cinnamomum cassia twig 6, and Zingiber officinale 15. The production method includes: supersonic air flow comminution, alcohol/water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray-drying, nanometer grinding, high-pressure homogenization, and nanoparticle preparation. The invention utilizes the advantages such as multi-cooperation and multi-target of the nano-carrier coupling technique. The invention can greatly reduce production cost and greatly increase product quality after large-scale production, and enhance the targeting effect and slow-controlled release effect of drug. The preparation can be administered orally and externally in four periods of time according to midnight-noon ebb-flow and human qi and blood flow rule. The preparation may also be prepared into pellicle and transdermal agent, which can be attached to different parts of human body according to midnight-noon ebb-flow and human qi and blood flow rule or be directly absorbed transdermally.
BACKGROUND: Sarcopenia is a progressive disease with age-related loss of skeletal muscle mass, strength, and function. No study has investigated the association between healthy beverage index (HBI) and sarcopenia in older adults. Therefore, the present study aimed to investigate the association between HBI and sarcopenia in Iranian older adults.
METHODS: In the present case-control study, 80 sarcopenic and 80 non-sarcopenic participants matched in sex were included. Body composition was measured using bioelectrical impedance analysis. Handgrip strength (HGS), skeletal muscle mass index (SMI), and gait speed were utilized to confirm sarcopenia. Also, a food frequency questionnaire was used to evaluate food intake. HBI score was calculated based on ten sub-components of the total beverages. Moreover, logistic regression was applied to assess the association between HBI and sarcopenia.
RESULTS: In the crude model, we observed no significant association between HBI and the odds of sarcopenia. Still, after adjusting the confounders, the odds of developing sarcopenia decreased significantly in the second and last tertiles (T) (T2- odds ratio (OR) = 0.04, 95% confidence interval (CI): 0.01-0.25 and T3- OR = 0.10, 95% CI: 0.01-0.60).
CONCLUSIONS: Our findings indicated that HBI is inversely related to the chance of sarcopenia. Therefore, to reduce the odds of sarcopenia, it is recommended to consume healthy drinks such as fruit juices and milk.
FIELD: dietotherapy. SUBSTANCE: association contains, as active ingredients, only carotinoid substance, nicotine substance, and zinc source in the form of their separate dosed forms. Association selectively complete these substances contained in common diet, which increases resistance of DNA against damage, enhance reparative capability of DNA, and stimulates immune function. Treatment methods for man and animals to achieve indicated effects consist in regular consummation of daily dose of the association no matter whether the same active ingredients are present or absent in common diet. It is also possible to administer daily dosed forms of active ingredients in selective way. EFFECT: enabled treatment of manifestation of a variety of painful conditions occurring, for example, in cases of ageing, cancer, cardiovascular diseases, and autoimmune disorders such as diabetes, rheumatoid arthritis, and nonspecific ulcer colitis. 9 cl, 9 dwg, 6 ex
This invention relates to CARM1, CARM1 binding pockets, or CARM1-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to CARM1 protein, complexes of CARM1 protein, homologs thereof, or CARM1-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising a CARM1 protein or homologs thereof. The invention also relates to methods of identifying binders of CARM1 proteins. The invention also relates to methods for determining the intracellular activity of CARM1 methyltransferase and methods for identifying an agent that inhibits the intracellular activity of CARM1 methyltransferase.
The invention relates to a bivalent inactivated vaccine, and specifically, relates to a freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine and an industrialized preparation method thereof. The freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine comprises inactivated antigen compositions of aeromonas hydrophila culture inactivated liquid and aeromonas sobria culture inactivated liquid. The invention also provides the industrialized preparation method of the freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine. The industrialized preparation method is characterized by comprising the following steps of mixing uniformly the aeromonas hydrophila culture inactivated liquid and the aeromonas sobria culture inactivated liquid according to a ratio of 1: 1, and carrying out aseptic loading to obtain freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine finished products. The freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine overcomes the defect that a monovalent vaccine has an effect only on a pathogen. The freshwater fish aeromonas hydrophila-aeromonas sobria bivalent inactivated vaccine has the effect of resisting two pathogens simultaneously by being applied once, and can be conveniently applied through immersion, injection or feeding after mixing with forage.
SCOPE: Liver injury is a major complication associated with sepsis. Together with others, the study has shown that gallic acid (GA) exerts anti-inflammatory and antioxidant effects in vivo. However, the role of GA in sepsis-mediated hepatic impairment and the underlying mechanisms remains to be elucidated.
METHODS AND RESULTS: C57BL/6J mice are pretreated with saline or GA and subjected to sham or cecal ligation and puncture (CLP). The pathological alterations are assessed by hematoxylin and eosin staining as well as immunohistochemical staining. RNA sequencing is employed to analyze hepatic transcriptome modifications. The study finds that GA supplementation significantly ameliorates CLP-induced mortality, liver dysfunction, and inflammation. RNA sequencing reveals that 1324 genes are markedly differentially regulated in livers of saline- or GA-treated sham or CLP mice. Gene ontology analysis demonstrates that the differentially expressed genes regulated by GA are predominantly correlated with the immune system process, oxidation-reduction process, and inflammatory response. Furthermore, mitogen-activated protein kinase (MAPK) signaling is localized in the center of the GA-mediated pathway network. Notably, activation of MAPK by C16-PAF significantly blocks GA-mediated protective effects on hepatic injury, inflammation, as well as CCAAT/enhancer-binding protein-β (C/EBPβ) dependent extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) signaling.
CONCLUSION: Therefore, this study indicates that GA may offer a promising therapeutic opportunity for sepsis-associated liver injury.
Prepn. of an effervescent plant-based prepn. is claimed, for the delivery of (A). (A) are plant-based pharmaceuticals and flavourings. Freshly harvested plant material is pressed to obtain juice, and enzyme activity is destroyed by a brief period of heating; up to 20% mono- and/or disaccharide is added to the juice for matrix formation; the juice is dried and converted to a powder (P); and (P) is mixed with a standard effervescent mixture to obtain the effervescent prepn. Also claimed is an effervescent preparation for carrying (A) contg. 0.1-50 wt.% of a powder obtd. from freshly harvested plant parts, esp. (P).
Most children engage in insufficient amounts of moderate-to-vigorous physical activity. These low levels of moderate-to-vigorous physical activity are associated with adverse health consequences including increased risk for obesity, and cardiovascular and diabetes risk factors. Therefore, there is a need for studies that can increase physical activity levels in children. Mobile phones are a way to deliver behavioral interventions. Mobile phones are portable, allow for real-time data collection, and can potentially reach large numbers of people. Text messages can also be utilized to promote behavior change. Few mobile phone based interventions have specifically targeted child physical activity.

The aims of this pilot study were to determine the feasibility and efficacy of a physical activity promotion program targeting 6-10 year old children that is delivered to parents through mobile phones.
Each dose of tobramycin inhalation solution is administered by oral inhalation using only the co-packaged PARI LC PLUS Reusable Nebulizer (Model No. 022B81-TA) included in the KITABIS PAK, along with a DeVilbiss Pulmo-Aide air compressor (Model No. 5650D). 

Tobramycin inhalation solution is not for subcutaneous, intravenous or intrathecal administration. 

Prior to administration, read the Patient Information/Instructions for Use for KITABIS PAK for detailed information on how to use KITABIS PAK and follow the manufacturer's instructions for use and care of the DeVilbiss Pulmo-Aide air compressor. 

The entire tobramycin inhalation solution treatment should take approximately 15 minutes to complete. Continue treatment until all the tobramycin inhalation solution has been delivered, and there is no longer any mist being produced. 

Tobramycin inhalation solution should not be diluted or mixed with other drugs including dornase alfa in the nebulizer. Instruct patients on multiple therapies to take their medications prior to inhaling the tobramycin inhalation solution, or as directed by their physician. 

Tobramycin inhalation solution should not be used if it is cloudy, if there are particles in the solution, or if it has been stored at room temperature for more than 28 days.
The invention discloses foot bath powder for strengthening body resistance and benefiting qi, which is prepared by compounding radix astragali preparata, radix dipsaci from Sichuan of China, angelica sinensis and safflower. The ZUguang powder has the effects of strengthening spleen and kidney and replenishing qi and blood, and the prepared astragalus root has the effects of strengthening spleen and tonifying qi, tonifying qi and strengthening exterior and the like, and is mainly used for treating spleen-qi deficiency syndromes such as lassitude, hypodynamia, poor appetite, loose stool and the like. Has effects in promoting metabolism, relieving fatigue, stimulating respiration, enhancing and regulating immunity, resisting aging, and resisting anoxia. Radix Dipsaci has effects of promoting fracture healing, resisting osteoporosis, regulating immunity, and resisting vitamin E deficiency. The angelica can promote the generation of hemoglobin and red blood cells, increase the blood flow of coronary artery, reduce the oxygen consumption of cardiac muscle and protect ischemic cardiac muscle. Carthami flos has effects of protecting and improving myocardial ischemia, reducing myocardial infarction range, and improving anoxia resistance of organism.
NEW MATERIAL:The imidazoquinoline derivative or imidazoiosquinoline derivative of formula I or formula II (R1 is lower alkyl; R2 is lower alkyl or alkali metal atom). USE:Useful as a cardiotonic agent for the remedy of cardiopathy such as congestive cardiac insufficiency. It has strong positively inotropic action to the heat, weak action to increase the heat rate and low toxicity. PREPARATION:The compound of formula I or formula II can be prepared by reacting the compound of formula III which phosgene or trichloromethyl chloroformate in the presence of a base (e.g. dimethylaniline, triethylamine, etc.), and reacting the reaction product with a lower alcohol. The reaction is carried out in an organic solvent such as benzene, acetone, etc.
Compositions for preventing or treating inflammatory diseases such as inflammatory diseases of the joint, multiple sclerosis, leukemia, ischemic injury or reperfusion injury, are described. A fusion protein comprising an interleukin-1 receptor antagonist (IL-1ra) with all or part of a constant domain of a heavy or light chain of human immunoglobulin at the carboxy terminus is also described. Three useful forms of IL-1ra (IL-1raa, IL-1raß and IL-1rax) and variants thereof are disclosed and described in US Patent No. 5,075,222.  Described herein are modified forms of IL-1ra.  The modified forms of IL-1ra include polypeptides in which amino acids have been deleted from, inserted into and substituted for residues within the amino acid sequence of IL-1ra. For IL-1ra addition variants, each polypeptide may include an amino- and/or carboxyl-terminus fusion ranging in length from 1>100 residues.
Smokers: Tobacco and marijuana smoking appears to increase the clearance of theophylline by induction of metabolic pathways. Theophylline clearance has been shown to increase by approximately 50% in young adult tobacco smokers and by approximately 80% in elderly tobacco smokers compared to non-smoking subjects. Passive smoke exposure has also been shown to increase theophylline clearance by up to 50%. Abstinence from tobacco smoking for one week causes a reduction of approximately 40% in theophylline clearance. Careful attention to dose reduction and frequent monitoring of serum theophylline concentrations are required in patients who stop smoking (see WARNINGS ). Use of nicotine gum has been shown to have no effect on theophylline clearance.
An 8-year-old castrated male Maltese dog was presented with a urinary bladder mass, urolithiasis, and hematuria. A solitary, pedunculated, intraluminal mass on the caudodorsal wall was identified with extensive irregular bladder wall thickening, and the mass was surgically removed. Postoperative histopathology demonstrated a submucosal lesion comprising spindle cells with marked inflammatory cell infiltration, without malignant changes. Immunohistochemical staining revealed vimentin and desmin positivity in the mass. An inflammatory myofibroblastic tumor (IMT) was definitively diagnosed. No recurrence was observed during a 43-month follow-up period. Although IMTs are rare in dogs, they should be considered a differential diagnosis for mass-like urinary bladder lesions accompanying a chronic inflammatory disease process. Key clinical message: Canine IMT should be included in the differential diagnoses of bladder masses, especially when dogs exhibit chronic irritation and inflammation.
The invention discloses a nasal cavity preparation and a preparing method and application thereof. The preparation is basically composed of sodium hyaluronate, a pH value adjusting agent, an osmotic pressure adjusting agent, a preservative and water. Besides, pharmacologic components such as menthol, camphor, ephedrine hydrochloride, dexamethasone and sodium cromoglycate are also added. During the preparation, according to the basic composition and the dosage of the formula, sodium hyaluronate is dispersed in water and then dissolved, the pH value adjusting agent, sodium chloride, the preservative and pharmacological activity materials are added, water is added to a preset amount, the mixture is filtered and sterilized with a millipore filter, and the obtained product is subpackaged, thereby obtaining the nasal cavity preparation. The nasal cavity preparation can be used as nasal cavity spraying agents, nasal cavity noise drops, nasal cavity cleaning agents and the like. The basic formula is simple, and different pharmacological activity substances can be compounded to achieve different effects.
This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by use of non-stochastic methods of directed evolution (DirectEvolution „¢ ). These methods include non-stochastic polynucleotide site-saturation mutagenesis (Gene Site Saturation Mutagenesis „¢ ) and non-stochastic polynucleotide reassembly (GeneReassembly „¢ ). Through use of the claimed methods, genetic vaccines, enzymes, and other desirable molecules can be evolved towards desirable properties. For example, vaccine vectors can be obtained that exhibit increased efficacy for use as genetic vaccines. Vectors obtained by using the methods can have, for example, enhanced antigen expression, increased uptake into a cell, increased stability in a cell, ability to tailor an immune response, and the like. This invention provides methods of obtaining novel enzymes that have optimized physical and/or biological properties. Furthermore, this invention provides methods of obtaining a variety of novel biologically active molecules, in the fields of antibiotics, pharmacotherapeutics, and transgenic traits.
Calorie restriction (CR) mimetic, resveratrol (RSV), has the capacity of promoting phagocytosis. However, its role in hepatic ischemia and reperfusion injury (HIRI) remains poorly understood. This study aimed to investigate the effect of RSV on alleviating HIRI and explore the underlying mechanisms. RSV was intraperitoneally injected in mice HIRI model, while RSV was co-incubated with culture medium for 24 h in RAW 264.7 cells and kupffer cells. Macrophage efferocytosis was assessed by immunostaining of PI and F4/80. The clearance of apoptotic neutrophils in the liver was determined by immunostaining of Ly6-G and cleaved-caspase-3. HE staining, Suzuki's score, serum levels of ALT, AST, TNF-α and IL-1β were analyzed to evaluate HIRI. The efferocytosis inhibitor, Cytochalasin D, was utilized to investigate the effect of RSV on HIRI. Western blot was employed to measure the levels of AMPKα, phospho-AMPKα, STAT3, phospho-STAT3 and S1PR1. SiSTAT3 and inhibitors targeting AMPK, STAT3 and S1PR1, respectively, were used to confirm the involvement of AMPK/STAT3/S1PR1 pathway in RSV-mediated efferocytosis and HIRI. RSV facilitated the clearance of apoptotic neutrophils and attenuated HIRI, which was impeded by Cytochalasin D. RSV boosted macrophage efferocytosis by up-regulating the levels of phospho-AMPKα, phospho-STAT3 and S1PR1, which was reversed by AMPK, STAT3 and S1PR1 inhibitors, respectively. Inhibition of STAT3 suppressed RSV-induced clearance of apoptotic neutrophils and exacerbated HIRI. CR mimetic, RSV, alleviates HIRI by promoting macrophages efferocytosis through AMPK/STAT3/S1PR1 pathway, providing valuable insights into the mechanisms underlying the protective effects of CR on attenuating HIRI.
BACKGROUND: Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age z score (zBMI) in Chinese preschool children.
METHODS: A total of 1046 participants aged 3.7 to 6.6 years old from the Long-term Health Effects Assessment Project of Infants and Toddlers Nutritional Pack (LHEAPITNP) were included in this study. The polygenic risk score (PRS) was established based on 55 BMI-related single nucleotide polymorphisms (SNPs) derived from a published genome-wide association study (GWAS) for BMI. Serum 25(OH)D was used as an index of vitamin D status and measured with liquid chromatography-tandem mass spectrometry (LC/MS-MS) assay. The Wilcoxon test or Kruskal-Wallis test was used to compare the differences of variables between different groups and Spearman correlation analysis was used for analyzing the correlations between the PRS, 25(OH)D levels, and zBMI.
RESULTS: The PRS showed a positive relation to zBMI (rs = 0.0953, p = 0.0022) and 25(OH)D showed a negative relation to zBMI (rs = -0.1082, p = 0.0005) in the full-adjustment model. In addition, the differences in zBMI at different vitamin D statuses in the low-risk PRS group and the intermediate-risk PRS group were both statistically significant (plow = 0.0308, pintermediate = 0.0121), the median zBMI was both higher at vitamin D insufficiency status. And the difference in zBMI between different genetic risk groups was also statistically significant at vitamin D sufficiency status (p = 0.0077). Furthermore, genetic risk showed a positive relation to zBMI at vitamin D sufficiency status, and the p for trend was 0.0028.
CONCLUSIONS: Our findings suggested that vitamin D was related to zBMI negatively in Chinese preschoolers and maintaining adequate vitamin D levels may only contribute to lower the zBMI in preschoolers with low and intermediate genetic susceptibility.
PURPOSE:To enhance safety, stability and the long acting property of effect, by using the saponin-containing extracted component, which is obtained by applying extraction treatment to the underground part of Ruscus aculeatus L. using an extraction solvent such as water, a hydrophilic org. solvent or water-containing hydrophilic org. solvent, as an effective component. CONSTITUTION:The underground part of Ruscus aculeatus L. is immersed in an about 5-20 time amount of water or a hydrophilic org. solvent such as methanol, ethanol or acetone or a mixture of both of them and pref. heated to about 40-80 deg.C. Saponin extracted by this method is used as an effective component of a deodorant. If necessary, purifying treatment such as the removal of a precipitate, decoloring treatment by activated carbon, treatment by a synthetic polymer adsorbent or the like is applied to the extract and the extraction solvent is distilled off and dried to obtain a saponin-containing extract having deodorizing function.