anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cancer dormancy followed by recurrence remains an enigma in cancer biology. Since both local and systemic recurrences are thought to emanate from dormant micrometastasis which take origin from lymphovascular tumor emboli we wondered whether the process of dormancy might initiate within lymphovascular emboli. This study combines experimental studies with a patient-derived xenograft (PDX) of inflammatory breast cancer (Mary-X) that spontaneously forms spheroids in vitro and budding lymphovascular tumor emboli in vivo with observational studies utilizing tissue microarrays (TMAs) of human breast cancers. In the experimental studies, Mary-X during both lymphovascular emboli formation in vivo and spheroidgenesis in vitro exhibited decreased proliferation, a G0/G1 cell cycle arrest and decreased mTOR signaling. This induction of dormancy required calpain-mediated E-cadherin proteolysis and was mediated by decreased P13K signaling, resulting in decreased mTOR activity. In observational human breast cancer studies, increased E-cadherin immunoreactivity due to increased E-cad/NTF-1 but both decreased Ki-67 and mTOR activity was observed selectively and differentially within the lymphovascular tumor emboli. Both our experimental as well as observational studies indicate that in vivo lymphovascular tumor emboli and their in vitro spheroid equivalent initiate dormancy through these pathways.
Participants randomized to the Food Allergy Mastery Program arm will participate in 6 telehealth intervention sessions with a trained mental health provider pertaining to food allergy education, food allergy management, anxiety and stress management, social situations, and self-efficacy. One of the 6 sessions is a group session with peers.
Conventional surgical procedures will carried out through a 3-4 cm incision in the groin. The trunk of GSV and the tributaries will be ligated and divided.
Arm 2 (Placebo) : Respondent has given bread with original flour (wheat flour) and vla original without dadiah. pregnant women received 1 pieces bread containing 50 gram and vla containing 30 gram.
The technique for the resection of the proximal interphalangeal joints in the patients with hammer-shaped deformities of the fingers with the complicated diabetes mellitus is performed as follows: The soft tissues are dissected in S-shaped mode. The corrected resection of the base of the middle phalange of the proximal interphalangeal joint is performed with dissection of the ulcer of the joint. From the dorsum of the distal phalange, the surgical procedure follows to the lateral surface of the finger at the level of the interphalangeal joint and then to the dorsum of the finger at the level of the metatarsophalangeal joint with access provided to the interphalangeal joint. The tendon of extensor digitorum longus is cut and moved aside proximally. The distal end of the proximal phalange is denuded to such extent that allows the preserved part of the phalange to be positioned at the level of other fingers. The oblique resection line is provided in the horizontal plane with the saw, and the operation wound is finally sutured.
Healthcare-associated infections present a challenge to healthcare systems, particularly critical care units. Hand hygiene emerges as a crucial element in infection control, acting as a vital link between healthcare workers, patients, and pathogens. Positive attitudes, motivated by a genuine concern for patient safety, are recognized as major predictors of hand hygiene compliance among healthcare workers. This study aims to assess the attitudes of ICU staff toward hand hygiene and identify factors that influence these attitudes. A cross-sectional survey of intensive care unit staff in seven large Saudi hospitals was conducted using an anonymous, self-reporting questionnaire to examine the attitudes of ICU personnel about hand hygiene and determine the factors that impact these attitudes. A regression analysis was used to determine the determinants of hand hygiene attitudes. Of the 600 respondents, 93% rated their hand hygiene knowledge as good, and 71% received hand hygiene training from their hospital. Most respondents (78%) had previously experienced healthcare-associated infections. The majority reported a favorable overall attitude toward hand hygiene (M = 4.15, SD = 0.85). Attitudes toward hand hygiene were significantly associated with perceived knowledge (β = 0.32, p < 0.001), prior hand hygiene training (β = 0.13, p < 0.05), and years of experience (β = - 0.10, p < 0.05). Healthcare workers in the ICU have a generally positive attitude toward hand hygiene. Such attitudes were correlated with hand hygiene knowledge, prior training, and job experience. The study's findings can help to inform health promotion initiatives and campaigns aimed at achieving long-term improvements in hand hygiene behaviors.
The present invention relates to a pharmaceutical composition, a food composition, and a food additive for preventing or alleviating andropause/andropause-related symptoms, comprising an extract of Ficus auriculata Lour. as an active ingredient. The extract of Ficus auriculata Lour. of the present invention suppresses PDE5 activity and thus shows effectiveness in preventing and alleviating erectile dysfunction; and suppresses AR and PSA expressions, and thus shows effectiveness in preventing and alleviating prostatic hyperplasia. Accordingly, the extract of Ficus auriculata Lour. of the present invention may be beneficially used as an active ingredient in a pharmaceutical composition, a food composition, and a food additive for preventing or alleviating andropause/andropause-related symptoms.
Children classified with JIA, in a low-to-medium disease activity and without having changed DMARD or bDMARD in the last 12 weeks are included. Only motivated children and parents can participate. Before inclusion the family are informed orally about the study plan, the diet and practical issues regarding the study and they receive written information including for example a product list and a recipe booklet. A dietician and the principal investigator follows the child and parents during visits, by mail and phone. After the baseline visit, the family has two weeks to get used to the new diet. At baseline, after two, four and twelve weeks on the diet the child is examined, blood exams are performed and blood is stored at -70, fecal samples and urine is also collected. At inclusion and after four weeks saliva sample for bacteria is collected. The child fills in the child health assessment questionnaire, (CHAQ) for a score of the physical ability and DisabKids for an overall assessment of the childs well-being.
PROBLEM TO BE SOLVED: To obtain a new compound different in action mechanism from the conventionally known antibiotics, and useful as an antimicrobial agent. SOLUTION: This compound is a compound of the formula ((k) and (m)are each 1-4, and k<=m; (n) is 1-12; but except the combination of k=1, m=2 and n=8). The compound of the formula is obtained by culturing microorganisms belonging to the genus Pseudoalteromonas and having the ability to produce the compound of the formula [pref. Pseudoalteromonas sp. F-420 strain (FERM P-16084)] by a liquid cultivation or the like, pref. at 30<= in a medium of pH 6-11 having a carbon source, a nitrogen source and the like, producing and accumulating the compound of the formula in the cultured product, and then- carrying out an isolated purification of the thus obtained compound through ethanol extraction, high performance liquid chromatography or the like and collecting the objective compound.
In this clinical trial, pediatric patients scheduled for removal of benign skin lesions in a single center willbe randomised to receive hypnosis (intervention group) or attention-distracting techniques (control group). Endpoints will be the sedative dose (propofol) during surgery, and the need for analgesia (paracetamol and others) immediately after surgery (recovery) and after 24 hours. Randomization will be systematic in blocks depending on the day the surgery is programmed. Hypnosis will be delivered by an experienced anesthesist trained in the technique. Patients and families will be informed of the special treatment during surgery, but will be unaware of whether the patients are experiencing distraction or hypnosis techniques. Distraction is already a useful technique, and it is expected that patients will be satisfied with the procedure; however, the hypothesis to be tested is that hypnosis reduces the need for sedation and analgesia compared to distraction techniques, as well as improves satisfaction.
NYVEPRIA is administered subcutaneously via a single-dose prefilled syringe for manual use.

Prior to use‚ remove the carton from the refrigerator and allow the NYVEPRIA prefilled syringe to reach room temperature for a minimum of 30 minutes. Discard any prefilled syringe left at room temperature for greater than 15 days.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. NYVEPRIA is supplied as a clear and colorless solution. Do not administer NYVEPRIA if discoloration or particulates are observed.

The NYVEPRIA syringe plunger stopper and needle cover are not made with natural rubber latex.

Pediatric Patients Weighing Less than 45 kg

The NYVEPRIA prefilled syringe is not designed to allow for direct administration of doses less than 0.6 mL (6 mg). The syringe does not bear graduation marks, which are necessary to accurately measure doses of NYVEPRIA less than 0.6 mL (6 mg) for direct administration to patients. Thus, the direct administration to patients requiring dosing of less than 0.6 mL (6 mg) is not recommended due to the potential for dosing errors. Refer to Table 1.
Parkinson's disease (PD) involves the degeneration of dopaminergic neurons in the substantia nigra (SNpc) and manifests with both classic and non-classic motor symptoms, including respiratory failure. Our study aims to investigate the involvement of the commissural and intermediate nucleus of the solitary tract (cNTS and iNTS) in the attenuated respiratory response to hypoxia in PD. Using a PD rat model induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum of male Wistar rats, we explored potential alterations in the population of Phox2b neurons or hypoxia-activated neurons in the NTS projecting to the retrotrapezoid nucleus (RTN). Additionally, we explored neuronal connectivity between SNpc and cNTS. Projections pathways were assessed using unilateral injection of the retrograde tracer Fluorogold (FG) in the cNTS and RTN. Neuronal activation was evaluated by analyzing fos expression in rats exposed to hypoxia. In the PD model, the ventilatory response, measured through whole-body plethysmography, was impaired at both baseline and in response to hypoxia. A reduction in Phox2b-expressing neurons or hypoxia-activated neurons projecting to the RTN was observed. Additionally, we identified an indirect pathway linking the SNpc and cNTS, which passes through the periaqueductal gray (PAG). In conclusion, our findings suggest impairment in the SNpc-PAG-cNTS pathway in the PD model, explaining the loss of Phox2b-expressing neurons or hypoxia-activated neurons in the cNTS and subsequent respiratory impairment during hypoxic stimulation. We propose that the reduced population of Phox2b-expressing neurons in the NTS may include the same neurons activated by hypoxia and projecting to the RTN.
Although significant progress has been made in the treatment of brain tumors, the prognosis remains dismal in patients with relapsed tumor. The outlook for infants and young children is also poor, primarily because of the limited use of radiotherapy, although a recent report suggested that vigorous combination chemotherapy alone improved the survival of young children without macroscopic metastases at diagnosis. The prognosis is also not satisfactory when a large residual tumor remains after surgery or when leptomeningeal seeding is present at diagnosis. Given the above situation, we plan to explore the possible efficacy of high-dose chemotherapy and autologous stem cell rescue in patients with high-risk embryonal tumors, relapsed brain tumors and in infants and young children with brain tumors.High-dose chemotherapy and autologous stem cell rescue has improved the survival of children with high-risk solid tumors. this treatment strategy is based on the hypothesis that a dose escalation might improve the survival of children with high-risk solid tumors.Many investigators demonstrated that further dose escalation using sequential high-dose chemotherapy and autologous stem cell rescue might result in additional improvements in the survival of patients with high-risk tumors. As embryonal brain tumors are a chemosensitive tumors, a strategy using high-dose chemotherapy might be effective in the treatment of high-risk embryonal brain tumors and relapsed brain tumors. In addition, it might defer or eliminate irradiation in infants and young children with brain tumors
Fifty (n=50) post-treatment patients with colorectal cancer or breast cancer, deemed high-risk of relapse. The study will use an adaptive continuous reassessment method (CRM) design to assign patients sequentially at trial entry to one of five escalated doses depending on the feasibility / tolerability of exercise therapy evaluated over the total treatment period. The primary objective of this phase 1a trial is to identify the RP2D of exercise therapy for further evaluation in the phase 1b trial.
<P>PROBLEM TO BE SOLVED: To provide an excellent PPARγ expression regulator containing a factor directly regulating the expression of the PPARγ, to provide excellent fat differentiation regulator, lipid metabolism regulator, osteoclast function regulator and inflammation regulator, capable of regulating the differentiation of a fat cell, the lipid metabolism, the osteoclast function, and the inflammation action by inhibiting the factor, and to provide a method for screening the PPARγ expression regulator.  <P>SOLUTION: The PPARγ promoter sequence includes a base sequence comprising a specific sequence. The excellent PPARγ expression regulator can directly regulate the PPARγ. The excellent fat differentiation regulator, lipid metabolism regulator, osteoclast function regulator and inflammation regulator exhibit the activity thereof through the inhibition of DBP, TEF, HLF, E4BP4 or the like. The efficient screening method for the PPARγ expression regulator is also provided.  <P>COPYRIGHT: (C)2011,JPO&INPIT
This invention provides an isolated nucleic acid molecule encoding a mammalian p57KIP2. This invention also provides vectors comprising the isolated nucleic acid molecule encoding a mammalian p57KIP2. This invention further provides a host vector system for the production of a mammalian p57KIP2. This invention also provides probes for the isolated nucleic acid molecule encoding a mammalian p57KIP2. This invention provides antibodies directed against a mammalian p57KIP2. This invention also provides transgenic animals comprising isolated nucleic acid molecules encoding a mammalian p57KIP2. Finally, this invention provides different uses of the mammalian p57KIP2.
A computerized system and method for measuring and analyzing provider utilization is disclosed. In an example embodiment, a Provider Utilization Management Software Application comprises a data selection component and a presentation model that illustrates how a provider's claim data submitted to a health benefits company compares to providers in the same network, geographic region, or other provider grouping (e.g., by state, zip code, MSA, provider specialty type, or in-plan status). This utilization data may be used to identify problem providers that have high, low, or unusual utilization patterns. Various measures may be calculated and analyzed. Results of the analysis may be presented in various reports. Once problem providers are identified, they may be monitored. In some instances, one or more corrective actions may be taken.
Transvaginal oocyte retrieval was performed under local anaesthesia and under guidance of ultrasound with the RN needle that had an outer diameter of 0.9 mm (20 gauge) and inner diameter of 0.6 mm for the last 50 mm from the tip of the needle and an outer diameter of 1.4 mm (17 gauge) and inner diameter of 1 mm for the remaining length of the needle. The puncture procedure was performed according to each clinic's standard routine. Aspiration pressure was kept at a negative pressure between 90 and 120 mmHg.
In everyday life, people often encounter the problems of traumatic injury and long treatment. Especially, athletes often suffer from trauma, which impedes the improvement of grades; and some athletes can not participate in the competition and lose a good chance of winning the medals because of sprains. Therefore, a specific medicine for activating blood circulation to remove stasis is developed. The medicine provided by the invention comprises dragon's blood, rhubarb, safflower, frankincense, camphor, mugwort leaf, mint, radix clematidis, cortex cereis and dimethyl sulfoxide, and the key to success lies in the quality of dragon's blood. The medicine is for external use, and the mechanism is to dredge the vascular stasis, promote blood circulation, and expel the diseases (gore) from the inside to the outside, so that the stasis can be absorbed, and the traumatic injury heals. Blood circulation relives the pain, and prevents cell necrosis due to retardance of extravasated blood; and the medicine can treat coronary heart disease, various thrombosis and rheumatoid arthritis, and skin diseases. This medicine is safe and quick in effectiveness, has wide medicine source, low cost and simple production process, and is an alternate and selective medicine suitable for the athletes in China.
RATIONALE AND OBJECTIVES: To establish a quantitative CT threshold for radiological disease progression of progressive pulmonary fibrosis (PPF) and evaluate its feasibility in patients with connective tissue disease-related interstitial lung disease (CTD-ILD).
MATERIALS AND METHODS: Between April 2007 and October 2022, patients diagnosed with CTD-ILD retrospectively evaluated. CT quantification was conducted using a commercial software by summing the percentages of ground-glass opacity, consolidation, reticular opacity, and honeycombing. The quantitative threshold for radiological progression was determined based on the highest discrimination on overall survival (OS). Two thoracic radiologists independently evaluated visual radiological progression, and the senior radiologist's assessment was used as the final result. Cox regression was used to assess prognosis of PPF based on the visual assessment and quantitative threshold.
RESULTS: 97 patients were included and followed up for a median of 30.3 months (range, 4.7-198.1 months). For defining radiological disease progression, the optimal quantitative CT threshold was 4%. Using this threshold, 12 patients were diagnosed with PPF, while 14 patients were diagnosed with PPF based on the visual assessment, with an agreement rate of 97.9% (95/97). Worsening respiratory symptoms (hazard ratio [HR], 12.73; P < .001), PPF based on the visual assessment (HR, 8.86; P = .002) and based on the quantitative threshold (HR, 6.72; P = .009) were independent risk factors for poor OS.
CONCLUSION: The quantitative CT threshold for radiological disease progression (4%) was feasible in defining PPF in terms of its agreement with PPF grouping and prognostic performance when compared to visual assessment.
1,253,373. Purification of crude terephthalic acid. TEIJIN Ltd. 7 Nov., 1968, No. 52908/68. Heading C2C. In a process for the continuous purification of crude terephthalic acid by recrystallization using as the solvent at least one of acetic, propionic and butyric acids or an aqueous solution of such fatty acid of water content no more than 50%, the purification is performed using at least two crystallization vessels in series, by feeding a solution of 6-40 parts by weight of crude terephthalic acid in 100 parts by weight of the solvent at an elevated temperature and pressure into the first crystallization vessel in which a lower temperature and pressure are maintained such as to cause evaporation as a result of the fall in pressure of 10-60% by weight of the solvent, whereby a part of the terephthalic acid is precipitated and the system is converted to a slurry; sending the slurry to the second, and optionally to one or more subsequent, crystallization vessels maintained at successively lower pressures such that in each vessel 10- 60% by weight of the solvent entering the vessel is evaporated as a result of the fall in pressure, whereby further terephthalic acid is precipitated, the solution and slurry respectively being fed directly into residual, previously formed slurry in the first and subsequent crystallization vessels, and the terephthalic acid concentration in each of the crystallization vessels being controlled at a level no higher than 60 parts by weight of terephthalic acid per 100 parts by weight of the solvent; withdrawing the terephthalic acid slurry from the last crystallization vessel; and recovering the terephthalic acid from the slurry.
The wealth created by crop pollination through bees is over 100 times of the output value of a bee product. More importantly, 'if bees disappear, human beings will disappear four years later' (said by Edison), while a disease of apis cerana is called sac brood and is called 'incurable cancer' of apis cerana in the bee industry; and if the sac brood occurs frequently and severely, great loss of the global wealth is caused. A novel Chinese-Western medicament is invented finally three years before by researching for years, testing repeatedly and absorbing the advantages of prescriptions of seniors. A (home-made) medicament can be used for curing the sac brood about one month, and is fed once every two days by being dissolving into honey water or white sugar water. Formula: Chinese and western medicaments are combined. A quarter to one tenth of a terramycin pill, a nysfungin pill, a qingkailing pill, and home-made Chinese medicines are added additionally.