anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PEP mask, 3 months. The treatment was performed twice a day, 1 hour each treatment.
Participants underwent catheterization with the new intermittent catheter Variant 1 for males or females. The catheterization was performed by a trained nurse.
In the treatment programme to be applied to the spinal rehabilitation group supported by artificial intelligence, the patient's treatment card is first created. Artificial intelligence assisted spinal rehabilitation group will be applied 3 times a week, a total of 6 sessions and 30 minutes of treatment. The person is first prepared by lying on his back on the stimulation mat. There are 12 channels and 24 electrodes in artificial intelligence assisted spinal rehabilitation. The stimulation wave travels in all 12 L-sized channels of the stimulation mat. The two sub-channels in the M dimension are not active, the wave travels over only 10 channels. In size S only 8 channels are used, therefore 4 sub-channels of the stimulation mat are not active Artificial intelligence-assisted spinal rehabilitation overcomes skin resistance more easily with mid-frequency currents in the 2000 - 6000 Hz range compared to currents in lower frequency ranges.
BACKGROUND: In diabetic wounds, M2 polarization of macrophages regulates the transition from an inflammatory phase to a proliferative phase. Prior investigations have demonstrated the potential of deferoxamine (DFO) in creating a localized hypoxic microenvironment, which could stimulate angiogenesis by promoting vascular endothelial growth factor (VEGF) secretion in diabetic wound healing. Nevertheless, there is still no clear information on whether this chemically induced hypoxic microenvironment modulates macrophage polarization to promote diabetic wound healing.
METHODS: The 18 diabetic mice were randomly divided into three groups: a control group (n = 6), a 100µM DFO group (n = 6), and a 200µM DFO group (n = 6). Subsequently, a full-thickness wound with a diameter of 1.00 cm was created on the dorsal region of the diabetic mice. Observe wound closure regularly during treatment. At the end of the observation, tissue specimens were collected for a series of experiments and analyses, including hematoxylin and eosin (H&E), Masson, immunofluorescent, and immunohistochemical staining. The role and mechanism of DFO in regulating macrophage polarization were studied using RAW264.7 cells.
RESULTS: In comparison to the control group, the administration of DFO notably facilitates wound healing in diabetic mice. In diabetic wounds, DFO increases blood supply by upregulating VEGF, which promotes angiogenesis. Additionally, The expression of HSP70 and CD206 were also upregulated by DFO in both vivo and in vitro, while iNOS expression was downregulated. Additionally, knk437 inhibited the expression of HSP70 in RAW264.7 cells, resulting in a reduction of M2 polarization and an increase in M1 polarization.
CONCLUSION: The induction of a hypoxic microenvironment by DFO has been found to exert a substantial influence on the process of diabetic wound healing. DFO treatment enhances the capacity of diabetic wounds to stimulate angiogenesis and modulate macrophage polarization that may be associated with HSP70 expression, thereby expediting the transition of these wounds from an inflammatory to a proliferative state.
Objectives. Co-occurrence of alcohol use disorder (AD) and posttraumatic stress disorder (PTSD) is common. Research supports exposure therapy as the front line treatment for PTSD as this approach is most likely to lead to sustained recovery from the disorder. However, individuals with AD are generally not offered exposure therapies because of beliefs that exposure would lead to engagement in greater alcohol use and other dangerous behaviors. Most research and clinical treatment for comorbid AD and PTSD (AD/PTSD) have involved coping skills based therapies that have generally not shown sustained reductions in alcohol use and PTSD symptoms. A growing body of evidence suggests these individuals with AD/PTSD are able to handle and benefit from exposure. This proposed trial will compare an integrated exposure psychotherapy to an integrated coping skills psychotherapy for the treatment of AD/PTSD. In addition, mechanisms of change for Veterans with AD/PTSD in both treatment conditions, including therapy process variables, changes in negative affect, and sleep problems, will be explored. This project addresses a critical barrier in the field - the widely held belief that individuals with AD and PTSD cannot tolerate exposure therapy, although it is the best practice treatment for PTSD. The fundamental rationale is to improve the evidence base that informs how patients with AD/PTSD can attain sustained recovery. The investigators propose a randomized controlled trial to evaluate an integrated exposure-based treatment for concurrent AD and PTSD. The primary aim will be to conduct a randomized controlled trial to evaluate the effects of integrated exposure psychotherapy when compared to a present-focused coping skills based intervention (Seeking Safety; SS) in 148 male and female Veterans who have AD and PTSD. The hypotheses are that at post-treatment both groups will show reductions in alcohol use, but the integrated exposure group will demonstrate greater reductions in PTSD symptoms than SS. At 5- and 8-month post-baseline follow-up, the integrated exposure group will have significantly fewer percent drinking days and fewer PTSD symptoms than SS. In addition, mechanisms of change in both treatment conditions will be examined.
FIELD: cellulose derivatives. SUBSTANCE: radioprotector and potentiating agent containing cellulose derivative and gossypol of formula I:   (I) wherein a = 3 wt %, b = 63 wt %, c = 34 wt %, and n= 530-532 is prepared by treating sodium carboxymethylcellulose with degree of substitution 0.65-0.80 with 5- 6% iodic acid aqueous solution in isopropyl alcohol medium at iodic acid solution-to-isopropyl alcohol weight ratio 1:1; washing thus treated sodium carboxymethylcellulose acidified with 6:4 isopropyl alcohol/water mixture; treating with gossypol or gossypol-acetic acid in amounts 10-20% of the weight of initial carboxymethylcellulose and then with potassium hydroxide aqueous solution followed by separating desired product by way of precipitating it with alcohol- or ketone-type solvent. Agent may be applied in the form of pharmaceutical composition with effective concentration of agent as active ingredient together with pharmaceutically acceptable carrier or solvent. Pharmaceutical composition can be provided as tablets or creams. EFFECT: increased yield of desired product, reduced consumption of gossypol and precipitating agent, and widened assortment of effective anti-infective and radioprotector agents. 10 cl, 12 tbl, 20 ex
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to neurology, neurooncology, and can be applied when it is necessary to deliver medications through blood-brain barrier (BBB). For this purpose intracarotidly ozonised physiological solution is introduced intracarotidly. Introduction is performed once with ozone concentration 0.7 mg/l and ozone dose 0.0035 mg/kg. ^ EFFECT: method allows to ensure increase of BBB permeability with simultaneous reduction of number of complications due to use of ozone, which in process of decay forms metabolites participating in various reactions at the cell level. ^ 1 tbl, 5 dwg
The risk stratification of cardiovascular disease (CVD) in asymptomatic individuals represents a major challenge. For this purpose, a lot of risk prediction models that take demographic and clinical characteristics into account have been developed. Although Framingham risk score (FRS) is most widely used among multiplr risk prediction models, it has some limitation for prediction of CVD especially in young adult and women. Recently, coronary artery calcium score (CACS) has known to be powerful screening method for CVD, however, it cannot detect the noncalcified coronary plaques (NCP), so it does not represent the entire spectrum of atherosclerotic plaques and it also cannot evaluate the degree of stenosis. On the contrary, Coronary CT angiography (CCTA)can provide detailed coronary artery anatomy and plaque imaging about the location, burden and characteristics of atherosclerotic plaque per se, which might give additional insight to stratify the risk of future cardiac events and therapy.

In this study, we will evaluate the prevalence and characteristics of subclinical coronary atherosclerosis on CCTA in asymptomatic population. And we will investiage the follow up data for major cardiac adverse event such as cardiac death, nonfatal myocardial infarction, unstable angina and revascularization. Therefore, we will finally evaluate the prognostic value of CCTA for risk stratification in asymptomatic adults in comparsion with conventional risk stratification such as FRS and CACS.
The invention discloses traditional Chinese medicine for treating damp and hot skin stagnation type infant chronic eczema and a preparing method thereof. The traditional Chinese medicine is made from root of damnacanthus macrophyllus sieb. ex miq. var. giganteus (makino) koidz., acanthaceae, limonium bicolor, radix aconiti, curious kadsura root stem, radish, asclepiadaceae, trichosanthes seed, valerian, sago seed, hemiphragma heterophyllum, root or leaf of cochinchina raspberry, panax pseudo-ginseng wsll. var, vernonia andersonii clarke, tylophora floribunda miq., kansui root, oblongleaf kadsura stem root and twin-sorus fern. The traditional Chinese medicine has the advantages that the medicine is definitely effective for treating infant chronic eczema and capable of becoming effective quickly, has few side effects, does not irritate the skin of infants, and is convenient to use, and relapse is unlikely to happen after cure.
Minimal residual disease (MRD) monitoring is currently performed in B-ALL patients to evaluate treatment response and define risk stratification. Patients with good prognosis have undetectable MRD levels after treatment, while persistent MRD defines high relapse-risk patients. A standardized flow cytometry assay detects MRD reliably in bone marrow or peripheral blood at levels ≥0.01% mononuclear cells. More sensitive MRD assay detecting specific immunoglobulin heavy (IgH) chain rearrangement by next-generation sequencing (NGS) can approach reliably detectable blast level at ≤10-6 cells. Given the high sensitivity, the NGS-MRD approach improves distinction between deeply negative and very low positive cases. Recent studies also demonstrate that NGS-MRD assessment of the bone marrow with undetectable blast cells is a strong predictive factor, indicating patients with possible long-term response after CAR-T cell therapy.

In the past decade, adoptively transferred T cells modified with chimeric antigen receptors (CARs) have demonstrated high effectiveness and changed the treatment paradigm for B-ALL. More than 80% B-ALL patients achieved complete remission due to CAR-T treatment, but some patients with CR still have MRD that ultimately leads to relapse, which indicates the importance for further combination therapy to enhance anti-tumor immunity and to eradicate all malignant cells. Therefore, this protocol includes multi-target CAR-T cell infusions followed by cytotoxic T lymphocyte (CTL)-based immunotherapy, which react with B-ALL tumor antigens, and then followed by injection of immune-modified dendritic cells fused with leukemic cells (DCvac). In addition to the significant success of CAR-T cell therapy, various clinical studies also reported the importance and potential benefits of using engineered tumor-specific T cells in different types of cancer. Moreover, DC-based vaccine as another agent of immunotherapy has proven to prevent or delay relapse in leukemia patients achieving remission. In this study, we propose to combine those strategies to augment anti-tumor immunity in patients and expect undetectable NGS-MRD remission to prevent disease recurrence.

We propose a novel protocol which combines multiple CAR-T cell therapy, engineered immune effector CTLs and DCvac against B-ALL. The aim of this study is to evaluate the feasibility, safety, and efficacy of the NGS-MRD analysis-based combinational immunotherapy.
Study participants will receive a single dose of the cocktail of probe drugs at pre-specified timepoints followed by a wash out period. The same study participants will then receive repeated oral doses of fenfluramine HCl (ZX008) and a single dose of the cocktail of probe drugs at pre-specified time points during this Treatment Period.
Subjects will be prescribed progesterone 200 mg look-alike placebo capsules by the study Principal Investigator. Subjects will take look-alike placebo capsules daily for four days.
Patients who are randomized into this arm will receive the same intervention as patients in Arm 2, except when patients arrive for their follow-up, the smoking educator will "check-in" with their progress for approximately 5 minutes. The techniques utilized during this check-in visit will include repetition of previously described motivational interviewing, at this point patients who elect to be referred to the quitline will be given this opportunity.
Ferroptosis hallmarked by lipid peroxidation and iron homeostasis imbalance is involved in the occurrence and development of various diseases. The plant growth regulator chlormequat chloride (CCC) can contribute to the causality and exacerbation of reproductive disorders. However, the mechanism by which CCC may cause Leydig cell attenuation remains poorly understood. In this study, TM3 Leydig cells were used to investigate the inhibitory effect of CCC on cell growth and its possible mechanism. The results showed that CCC caused apoptosis, pyroptosis, ferroptosis and necroinflammation in TM3 cells. By comparing the effects of ferroptosis inhibitor Ferrostatin-1 (Fer-1) and pan-Caspase inhibitor Z-VAD-FMK (ZVF) on lipid peroxidation and Caspase-mediated regulated cell death (RCD), we found that Fer-1 was better at rescuing the growth of TM3 cells than ZVF. Although ZVF reduced mitochondrial ROS level and inhibited the activation of Caspase3 and Caspase1, it could not significantly ameliorate lipid peroxidation and the levels of IL-1β and HMGB1 like Fer-1. Therefore, ferroptosis might be a key non apoptotic RCD mode responsible for CCC-driven inflammation, leading to weakened viability and proliferation of TM3 cells. In addition, overexpression of ferritin light chain (FTL) promoted the resistance of TM3 cells to CCC-induced ferroptosis-mediated inflammation and to some extent improved the inhibition of viability and proliferation. Altogether, ferroptosis-initiated inflammation might play a key role in CCC-impaired TM3 cell growth.
The prodromal phase of schizophrenia provides an optimal opportunity to mitigate the profound functional disability that is often associated with fully expressed psychosis. Considerable evidence supports the importance of neurocognition in the development of interpersonal (social) and academic (role) skills. Further findings from adolescents and young adults at clinical high risk for developing psychosis (CHRP) suggest that treatment for functioning might be most effective when targeting early and specific neurocognitive deficits. The current study addresses this critical intervention issue by examining the potential of neurocognitive deficits at intake for predicting social and role functioning over time in CHR-P youth. The study included 345 CHR-P participants from the second phase of the North American Prodrome Longitudinal Study (NAPLS2) with baseline neurocognition and 2-year follow-up data on social and role functioning. Slower baseline processing speed consistently predicted poor social functioning over time, while attention deficits predicted poor role functioning at baseline and follow-up. In addition, the impact of processing speed and attention impairments on social and role functioning, respectively, persisted even when adjusting the regression models for attenuated positive, negative, and disorganized symptoms, and transition status. The current study demonstrates for, arguably the first time, that processing speed and attention are strongly predictive of social and role functioning over time, respectively, above and beyond the impact of symptoms and those CHR-P individuals that develop psychosis over the course of the study. These findings imply that early neurocognition is a critical treatment target linked to the developmental trajectory of social and role functioning.
Clostridium difficile is the leading infectious cause of nosocomial diarrhea in developed countries. Hospital outbreaks of Clostridium difficile-associated diarrhea (CDAD) are associated with substantial patient morbidity and mortality. Conventional therapy with antibiotics often results in secondary infection with resistant organisms or clinical relapse after discontinuation of the antimicrobial course. New strategies are needed to limit the impact of this opportunistic pathogen. Considerable evidence exists that immunity against C. difficile toxins may be effective in controlling CDAD. 48 subjects will be enrolled to receive one of three dose levels of modified C difficile vaccine or placebo administered on a 3-dose schedule. The study consists of a 30-day screening period, a 70-day treatment period, one follow-up phone interview 2 months after the last vaccination, and one follow-up clinic visit 6 months after the last vaccination.
This invention discloses a method of extracting biao-gao-yi-chun from isatis root. The procedures include (a) ethanol water solution is back flow extracting solution and its weight is 30-95% of 6-12 times isatis root weight, then extracting solutions are combined. (b) Ethanol is recovered after filtration and then liquor is got. (c) The liquor flows through big holes resin adsorption column. (d) Scrubbing column is scrubbed by scrub solution until effluent liquid is leuko. (e) It is eluted by 30-95% weight percentage ethanol water solution, and eluent is collected. (f) The eluent is dried and solid substance is got. (g) Average particle diameter is -0.001-2mm powder is got after grinding. (h) The powder got from (g) is added to alumina column, (i) gradient elution is done by chloroform and ethanol component solvent, every 200-1000ml is one flow portion in order to add 0.1-2ml methanol after collecting every 50 portion. (j) The portions contain biao-gao-yi-chun are collected. (k) Solvent is discharged from the portion in (j), and then biao-gao-yi-chun extract product is got. This invention also provides the use of biao-gao-yi-chun in preparing antivirus medicine.
As a 1:1 ratio control group matched for age, gender and surgical implant. All patients were operated within 24 h with a cephalomedullary nail due to a trochanteric or subtrochanteric hip fracture.
The main study will randomize participants to one of two conditions, an intervention condition ("immediate") and a no-intervention control ("delayed"). For the control "quit on your own" condition, we will offer a 6-month "Delayed" treatment condition (DC) and will inform participants that we are testing whether smokers who are motivated enough to seek Internet information on smoking cessation can quit on their own at the same rate as smokers who are given access to an interactive stop smoking Web site. For our intervention, the "Immediate" treatment condition (IC) is the UCSF Spanish/English Stop Smoking research Web site (www.stopsmoking.ucsf.edu) that provides smokers their preference of all elements tested in earlier trials: 1) a Web version of a National Cancer Institute-designated evidence-based intervention with updated content, the Guía para Dejar de Fumar; 2) A document summarizing pharmacological treatment to aide smoking cessation available over the counter such as nicotine gum or patch or by prescriptions from a clinician; 3) e-mail reminders to return to the site timed to individually set quit dates; 4) a mood management smoking cessation intervention; and 5) a virtual group (an asynchronous bulletin board designed to let participants provide mutual support). We will recruit study participants until we have randomized 1200 HL smokers in English or Spanish stratified by gender within language group. Participants will be followed at 1, 3, 6, and 12 months after randomization to obtain self-reported prolonged abstinence and 7- and 30-day time point prevalence rates. E-mail reminders will be sent to remind participants to return to the site to complete follow-up surveys online. Only HL smokers from the US will be followed up by telephone calls at 1 and 6 months. The main comparison measure will be cessation at 6 and 12 months from original randomization. DC participants will be able to access the interactive site after finishing the 6-month follow-up. We plan to attract Spanish-speaking HL participants to our Web site using Spanish-language TV and radio interviews and public service announcements (PSA), Spanish-language Google ads and networking with U.S. cessation groups.
The invention relates to the field of traditional Chinese medicine health care, in particular to a traditional Chinese medicine composition and a health food preparation for enhancing immunity. The feed is prepared from the following raw materials in parts by weight: 1-50 parts of chicory, 20-80 parts of poria cocos and 1-35 parts of medicinal cyathula root. Chicory belongs to liver, gallbladder and stomach channels, poria cocos belongs to heart, lung, spleen and kidney channels, and radix cyathulae belongs to liver and kidney channels. All the herbs are used together to regulate the five internal organs, so when one herb is used alone, the property of the herb is rather biased and it is difficult to treat all the internal organs. Chicory has the effects of clearing liver, promoting bile flow, invigorating stomach, promoting digestion, and inducing diuresis to alleviate edema; poria has effects in invigorating spleen and stomach, promoting diuresis, eliminating dampness, and tonifying kidney; achyranthes bidentata can remove dampness and remove toxicity. Has the effects of strengthening spleen and stomach, promoting diuresis and purging turbid pathogen. It has no incompatibility and mild property. Strengthen the body resistance and consolidate the constitution, remove dampness and eliminate pathogenic factors, take the root and symptoms into consideration and bring out the best in each other. Can effectively play the health care functions of enhancing immunity and simultaneously improving various metabolic disorders.
Dehydrating and simultaneously resalinating medicinal mixts. stabilised by alkali-hydrogen-carbonate(s) of new crystalline forms(s) contain: 90 (Sic-no units provided) sodium, 20 potassium, 80 chloride, 30 hydrogen carbonate, 110 glucose and/or water sol. salts of other metals pref 0.2-2.5 magnesium or calcium (or both in combination). The quoted values are to be dissolved in 1 dm/3 of water. Other overall quantities may be used provided m molar ratios are maintained in the mixts.. Alkali-hydrogen carbonates are present in these mixts. either as an isomorphic crystalline modification of carbon-dioxide satd. sodium-hydrogen-carbonate or as a heteromorphic, non-stoichiometric modification, obtd. from carbon dioxide satd. 0.25-2 mols of potassium-hydrogen-carbonate and 1 mol sodium-hydrogen-carbonate, by compressor. Alkali-hydrogen-carbonates are added to the mix in granular form of 177-841 micro-m. size; The size range of added anhydrous glucose is 250-1000 microns. Foregoing components are mixed with anhydrous alkali-chlorides and opt. flavouring and colouring agents, and are administered dissolved in water.