anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Starting in 2001, the Look AHEAD study randomized 5145 patients with type 2 diabetes to an intensive lifestyle intervention (ILI) focused on weight loss versus a control group receiving diabetes education ("Diabetes Support and Education").The Look AHEAD study tested whether participants with type 2 diabetes assigned to an intensive lifestyle intervention (ILI) for weight loss exhibited reductions in cardiovascular morbidity and mortality, relative to a control group receiving usual care and diabetes support and education. During the 12-year intervention period, the ILI led to persistent reductions in weight, waist circumference, and hemoglobin A1c and improvements in physical fitness, among other clinical benefits. After the conclusion of the intervention in 2012, participants were consented to be linked with administrative data. The investigators attempted to link 3188 consenting participants with Social Security Administration databases. Of these, the investigators were able to successfully link 3093 participants. In this study, the investigators will compare participation in federal disability insurance programs including Social Security Disability Insurance (SSDI) and disability-related Supplemental Security Income (SSI) between the linked ILI and the control group during and after the intervention period (2001-2017). The investigators will investigate ILI-versus-control differences in whether participants ever applied or received benefits from SSDI and SSI. The investigators will also investigate ILI-versus-control differences in applications and benefit receipt in each year after randomization, relative to a pre-randomization assessment period. The investigators will use both multivariate regression controlling for baseline participant characteristics and clinic site and also survival analyses that estimate whether the time until SSDI or SSI application or benefit receipt differs between the ILI and control groups.
PURPOSE:To provide a bathing agent composition capable of preventing troubles such as skin inflammations due to sunburn, and of imparting the skin with favorable touch feeling. CONSTITUTION:The objective bathing agent composition formulated with a 4-methoxycinnamic acid compound such as 4-methoxycinnamic acid, its salt, ester, or amide (pref. 2-ethylhexyl 4-methoxycinnamate). The amount of the above active ingredient to be formulated is pref. such as to be 0.0001-0.1wt.% in its concentration when this composition is dissolved or dispersed in bathing water. This composition can also be formulated with inorganic salt, inorganic acid, organic acid, crude drug, coloring matter, fatty oil, vitamin(s), fragrance, etc.
The prospective, longitudinal part of the study will include an arm with 120 AAA patients undergoing endovascular aneurysm repair (EVAR), with a 24-month follow-up period. Clinical data collection, and blood sampling will be conducted at baseline, at 1 month after EVAR and at 6, 12, 18 and 24 months after EVAR. CT will be conducted at baseline, at 1 month after EVAR and at 12 and 24 months after EVAR patients. Quality of life and depression questionnaires will be performed at baseline, at 1 month, at 12 and 24 months of follow-up after EVAR.
BACKGROUND: Primary thyroid lymphoma (PTL) is a rare malignant disorder, and ultrasound plays an important role in PTL diagnosis and follow-up surveillance. Prediction of refractory/relapse events in PTL patients is an essential issue, yet no ultrasonic PTL features have been discovered to be related to refractory/local relapse events.
METHODS: From January 2008 to September 2022, newly diagnosed PTL patients in our center who underwent standard first-line treatment and received an ultrasound examination before treatment were enrolled. Data regarding patients' clinical and sonographic features, as well as their therapeutic responses were collected. Subjects with an ideal prognosis were compared to those with refractory/relapse events.
RESULTS: In total, 37 PTL patients were analyzed, including 26 with diffuse large B-cell lymphoma, 2 with follicular lymphoma and 9 with mucosa-associated lymphoid tissue lymphoma. During the median follow-up of 25 months, 30 patients obtained a complete response, 4 were refractory patients, and 3 experienced local relapse. No significant difference was detected in the baseline clinical characteristics between patients with an ideal prognosis and those with refractory/local relapse events. In terms of sonographic features, however, an event-free survival (EFS) curve comparison revealed that patients with bilobar enlargement (defined as an anterior-posterior diameter > 2.5 cm on both sides of thyroid lobes) had a poorer EFS than those without (P < 0.0001), and patients with diffuse type had a poorer EFS than those with mixed/nodular types (P = 0.043). No significant difference was observed in EFS between patients with or without signs of suspicious cervical lymph node metastasis, rich blood signal distribution or symptoms of trachea compression.
CONCLUSIONS: PTL patients with an anterior-posterior diameter > 2.5 cm for both thyroid lobes or PTL patients of the diffuse ultrasound type could be prone to refractory/local relapse events.
The invention belongs to the technical field of tumor immunotherapy, and particularly discloses an anti-tumor fusion exosome and a preparation method and application thereof. The exosome derived from tumor cells is fused with liposome to serve as a vector, and plasmids expressing XCL1 and FLT3L are encapsulated into the vector to obtain the fused exosome capable of increasing the number of cDC1 in tumors. By loading the AS16 peptide on the surface of the fused exosome, blocking the inhibition of cDC1 by VEGF. Simultaneously, loading an agonist MPLA of a TLR4 pathway in a hydrophobic cavity fused with an exosome membrane phospholipid bilayer, and activating cDC1 and CD8  +  T cell, promotion of CD8  +  Infiltration of T cells into tumors and secretion of IFN-. Gamma.. The invention adopts a progressive mode in turn, firstly increases the quantity of the cDC1 in the tumor, then removes the inhibition of the cDC1, reactivates the cDC1, and integrally recovers and enhances the function of the cDC1, thereby inhibiting the tumor growth.
A 2-hour in-person informational session about general health education. Participants receive a list of resources in the community.
Despite the recognition that epilepsy can substantially disrupt memory, there are few published accounts of whether and how this disruption varies across different types of memory and/or different types of epilepsy. This review explores four main questions: (1) Are working, episodic and semantic memory differentially affected by epilepsy? (2) Do various types of epilepsy, and their treatment, have different, specifiable effects on memory? (3) Are the usual forms of neuropsychological assessments of memory - many or most designed for other conditions - appropriate for patients with epilepsy? (4) How can research on epilepsy contribute to our understanding of the neuroscience of memory? We conclude that widespread and multifactorial problems are seen in working memory in all patient groups, while patients with temporal lobe epilepsy seem particularly prone to episodic memory deficit, and those with frontal lobe epilepsy to executive function deficits that may in turn impair semantic control. Currently, it is difficult to make individual patient predictions about likely memory deficits based on seizure aetiology and type, but it is possible to guide and tailor neuropsychological assessments in an individualised way. We make recommendations for future directions in validating and optimising neuropsychological assessments, and consider how to approach effective shared decision making about the pros and cons of seizure treatment strategies, especially at crucial educational stages such as adolescence.
Blind football players use head movements to accurately identify sound location when trapping a ball. Accurate sound localization is likely important for motor learning of ball trapping in blind football. However, whether head movements affect the acquisition of ball-trapping skills remains unclear. Therefore, this study examined the effect of head movements on skill acquisition during ball trapping. Overall, 20 sighted male college students were recruited and assigned to one of the following two groups: the conventional training group, where they were instructed to move leftward and rightward to align their body with the ball's trajectory, and the head-movement-focused group, where they were instructed to follow the ball with their faces until the ball touched their feet, in addition to the conventional training instructions. Both groups underwent a 2-day training for ball trapping according to the specific instructions. The head-movement-focused group showed a decrease in errors in ball trapping at near distances and with larger downward head rotations in the sagittal plane compared to the conventional training group, indicating that during the skill acquisition training for ball trapping, the sound source can be localized more accurately using larger head rotations toward the ball. These results may help beginner-level players acquire better precision in their movements while playing blind football.
Babbling is an important precursor to speech in infancy, and deviations from the typical babbling development can predict later difficulties in speech, language, and communication. This cross-sectional study aimed to investigate babbling and early speech in Swedish extremely premature infants. Samples of babbling were collected from 20 extremely premature infants (EPT group) at the corrected age of 12 months. Data collection was home-based and consisted of an audio-video recording of each infant playing with a parent. Presence of canonical babbling (CB), and three oral stop variables distinctive of typical babbling, and consonant inventory were assessed. The assessment was performed during a standardised observation of babbling. Data from the EPT group were compared to previously collected data of a reference group of 20 10-month-old infants without known medical diagnoses. The results showed that the EPT group had a lower proportion of infants producing CB, and that they used a significantly smaller consonant inventory compared to the reference group. Although not statistically significant, oral stops were less frequently found in the EPT group. The findings of a restricted consonant inventory and low proportion of CB in the EPT group are not surprising considering that the group has been found to be at risk of speech and language delay in toddlerhood. Still, further research is needed to explore whether babbling at 12 months can predict speech and language skills at an older age in extremely premature infants.
<P>PROBLEM TO BE SOLVED: To provide a fluidized layer apparatus which effectively works even in a greatly minute amount of feeding compared with a conventional laboratory machine.  <P>SOLUTION: The fluidized layer apparatus has a fluidization vessel 6, a porous plate 10, a lower-side spray nozzle 17, a bag filter 5, an upper-side spray nozzle 31, a back-washing nozzle 39 and a back-washing elevator 40. The fluidization vessel 6 is formed in the shape of a cylinder of inverse cone trapezoid. The porous plate 10 is arranged to close a lower-part opening of the fluidization vessel 6. The lower-side spray nozzle 17 ejects air into the fluidization vessel 6 through the porous plate 10. The bag filter 5 is arranged at the upper-part opening of the fluidization vessel 6. The upper-side spray nozzle 31 sprays a spray liquid towards lower part. The back-washing nozzle 39 ejects air from the outer side of the bag filter 5 to the inner side so that particulates adhering to the bag filter 5 are brushed out, and is made to move up and down by the back-washing elevator 40. The fluidization vessel 6 is possibly made to vibrate by a vibrator 37.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Inflammation is elicited by the host in response to microbes, and is believed to be essential for protection against infection. However, we have previously hypothesized that excessive or misplaced inflammation may be a major contributor to tissue dysfunction and death associated with viral and bacterial infections. The resolutive phase of inflammation is a necessary condition to achieve homeostasis after acute inflammation. It is possible that targeting inflammation resolution may be beneficial for the host during infection. In this review, we summarize the evidence demonstrating the expression, roles and effects of the best described pro-resolving molecules in the context of bacterial and viral infections. Pro-resolving molecules play a pivotal role in modulating a spectrum of pathways associated with tissue inflammation and damage during both viral and bacterial infections. These molecules offer a blend of anti-inflammatory, pro-resolving and sometimes anti-infective benefits, all the while circumventing the undesired and immune-suppressive unwanted effects associated with glucocorticoids. Whether these beneficial effects will translate into benefits to patients clearly deserve further investigation.
Sepsis is a highly prevalent and deadly disease. Currently, there is a lack of ideal biomarker prognostis models for sepsis. We attempt to construct a model capable of predicting the prognosis of sepsis patients by integrating transcriptomic and proteomic data. Through analysis of proteomic and transcriptomic data, we identified 25 differentially expressed genes (DEGs). Single-factor Cox-Lasso regression analysis identified 16 DEGs (overall survival-DEGs) associated with patient prognosis. Through multifactor Cox-Lasso regression analysis, a prognostic model based on these 16 genes was constructed. Kaplan-Meier survival analysis and receiver operating characteristic curve analysis were used to further validate the high stability and good predictive ability of this prognostic model with internal and external data. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of overall survival-DEGs and differentially expressed genes between high and low-risk groups based on the prognostic model revealed significant enrichment in immune-related pathways, particularly those associated with viral regulation.
Tooth decay is one of the most widespread diseases in the world. Very often, a patient comes to the dental clinic when experiencing pain which commonly means the decay is deep and is very close to or has penetrated the nerve of the tooth. When the decay is very close to the pulp or nerve of the tooth, a procedure called pulp capping is done in an attempt to save the tooth and to prevent root canal treatment. A material has been introduced to the market for this purpose, called Biodentine. This study aims to investigate the nerve response to this material and to assess the quality of the overlying filling compared to another material (glass ionomer cement) used more commonly. Also, X-rays are a routine procedure used to assess how close the decay is to the nerve and to see if there are abnormalities around the tooth. However conventional X-rays may not be accurate. A new technique called Cone Beam Computed Tomography (CBCT) has been developed which shows a 3-D image of the tooth and may be more accurate. We aim to compare the images gained from conventional X-rays and CBCT to help improve diagnosis and care planning for patients.
In the randomized RCC trial (VEG105192), proteinuria occurred in 9% of 290 patients who received VOTRIENT. In 2 patients, proteinuria led to discontinuation of VOTRIENT. 

In the randomized STS trial (VEG110727), proteinuria occurred in 1% of 240 patients and nephrotic syndrome occurred in 1 patient. Treatment was discontinued in the patient with nephrotic syndrome. 

Perform baseline and periodic urinalysis during treatment with follow up measurement of 24-hour urine protein as clinically indicated. Withhold VOTRIENT then resume at a reduced dose or permanently discontinue based on severity of proteinuria. Permanently discontinue in patients with nephrotic syndrome [see Dosage and Administration (2.2)].
The invention relates to rhodizoside A with the functions of resisting bacteria, eliminating free radicals and inhibiting tyrosinase activity and a preparation method thereof, belonging to the technical field of extraction and preparation of biological products. The fumososide A is light yellow brown powder at 200 mg/mLAt the concentration, the inhibition zone for Escherichia coli is 18.6 mm, and the inhibition zone for white streptococci is 21.3 mm. Half-scavenging concentration (DC) of the free radical of Diphenylpicrylphenylhydrazine (DPPH) 50 ) Comprises the following steps: 260. mu.g/mL. Median Inhibitory Concentration (IC) on tyrosinase 50 ) Comprises the following steps: 79 μ g/mL. The rosmarin A can be obtained by culturing cordyceps militaris and then extracting and separating. The fumososide A disclosed by the invention can be used for preparing antibacterial and antifungal antibacterial agents, free radical scavengers and tyrosinase inhibitors, and has the potential of preparing antioxidant, whitening and anti-aging health-care products. The preparation method of the invention adopts microbial fermentation production, is environment-friendly, is not influenced by natural environment and resources, and is easy to realize industrialized, automatic and continuous production.
A single treatment will be administered for both eyes for each subject. The treatment will be administered for 11 minutes per treated eye.
The study shows that ascorbic acid and its combination with some natural compounds could be included in developing preventive and therapeutic approaches toward the current pandemic. Some natural compounds were effective in lowering ACE2 cellular expression, with the highest inhibitory effects observed for baicalin (75%) and theaflavin (50%). Significantly, combinations of these and other test compounds with ascorbic acid further decreased ACE2 expression. The highest impact of ascorbate on ACE2 expression was noted when combined with theaflavin (decrease from 50% to 87%), zinc aspartate (decrease from 22% to 62%), and with 10-undecenoic acid (from 18% to 53%). Our study provides valuable experimental confirmation of the efficacy of micronutrients in controlling ACE2 expression—the coronavirus cellular “entry” point. It further validates the importance of nutrient interactions in various aspects of cellular metabolism and in considering potential therapeutic applications of nutrient-based approaches.
The primary cause of adverse maternal health outcomes has been identified to be the delay in reaching care. This is often attributed to the long distances women need to travel to gain access to health facilities. Literature shows that maternity waiting homes contribute significantly to the reduction of maternal death and stillbirth among users. Despite its importance in improving maternal and neonatal health outcomes, the utilization of MWHs is very low in Ethiopia. So, it is important to investigate what strategies could be effective in improving MWH utilization in Ethiopia.

The aim of this study is to evaluate the effect of male partner involvement intervention on MWH utilization in Hadiya Zone, Southern Ethiopia. A cluster-randomized controlled trial will be performed. The intervention will have two arms, i.e., intervention and control. It will be a behavioral intervention. The interventions will be health education, home visit, and the provision of Information Education Communication (IEC) materials/leaflets. Health education will be delivered to "husband-expectant wife" pairs at the baseline. Then home visits will be conducted two times (in the third and fifth months of the intervention period). Leaflets will be provided to the study participants three times, i.e., at the baseline and during every home visit. The study participants will be pregnant women at the beginning of their second trimester living with their male partners at the time of the study.

Randomization will be conducted at the cluster level. Clusters will be Kebeles'. There will be 16 clusters or Kebeles. Data collectors (assessors) will be masked. The trial sample size will be 320 \[160 in each arm\]. A Generalized Estimating Equations model will be used. Data analysis will be conducted by SPSS or STATA software (as appropriate) using an Intention-To-Treat Approach. The duration of the intervention will be six months.
After experiencing an acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) is a preferred method of restoring blood flow to the heart. While this reperfusion has long-term benefits, it can result in reperfusion injury in the short term, which involves the formation of reactive oxygen species (ROS) and neutrophil recruitment. FDY-5301 is a sodium iodide-based drug that acts as a catalyst in the conversion of hydrogen peroxide to water and oxygen. FDY-5301 is designed to be administered as an intravenous bolus following a STEMI, before reperfusion with PCI, to reduce the damage associated with reperfusion injury. Clinical trials have shown FDY-5301 administration to be safe, feasible, and fast-acting in its ability to increase plasma iodide concentration, and the results are favorable in demonstrating potential efficacy. FDY-5301 shows potential in its use to reduce the effects of reperfusion injury, and ongoing Phase 3 trials will allow for continued evaluation of its performance.
FIELD: chemistry.SUBSTANCE: invention can be used in biomedicine. Method for producing clusters of magnetite nanoparticles involves heating solution of iron compound in high boiling organic solvent in inert gas atmosphere in presence of 1,2-hexadecanediol and organic acid and subsequent separation of resulting clusters. As the iron compound, iron (III) compound or iron pentacarbonyl is used. When iron pentacarbonyl is used as iron compound, after heating its solution in inert gas atmosphere, it is further heated in presence of oxygen. As organic acid, cyclopropanecarboxylic acid or 1-indanecarboxylic acid or mixture of oleic acid with one of acids selected from group consisting of biphenyl-4-carboxylic acid and cyclopropanecarboxylic acid is used. Solution is heated at a temperature not lower than 210 °C.EFFECT: invention makes it possible to improve magnetic properties of clusters from magnetite nanoparticles, in particular, to increase magnetization values and T-relaxivity.1 cl, 7 ex