anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a liquid formulation for internal use, blended with taurine, hardly showing a browning even blending an isomerized sugar by blending the isomerized sugar from which a ninhydrin reactive substance is eliminated, with the liquid formulation blended with taurine. SOLUTION: This liquid formulation blended with taurine is obtained by blending (A) preferably 5-48 w/v% isomerized sugar (a sugar material consisting of mainly fructose and glucose, and concretely a fructose glucose liquid sugar, a glucose fructose liquid sugar, a high fructose liquid sugar, etc.) from which a ninhydrin reactive substance [e.g.; concretely, a secondary amine, an amino acid (glycine, etc.), a protein, a peptide, etc.], is substantially eliminated, based on the total of the liquid formulation and (B) preferably in the concentration range of approximately 8 g/100 ml taurine at most. The pH of the liquid formulation is preferably made as 2-6, more preferably 2.5-4.5.
OBJECTIVE: To assess the additional health care utilization, cost, and mortality resulting from three surgical site infections (SSIs): mediastinitis/SSI after coronary artery bypass graft, SSI after bariatric surgery for obesity, and SSI after certain orthopedic procedures.
METHODS: This retrospective observational cohort study used commercial and Medicare Advantage/Supplement claims from 2016 to 2021. Patients with one of three SSIs were compared to a 1:1 propensity score-matched group of patients with the same surgeries but without SSI on outcomes up to one year postdischarge.
RESULTS: The total sample size was 4,620. Compared to their matched cohorts, the three SSI cohorts had longer mean index inpatient length of stay (LOS; adjusted days difference ranged from 1.73 to 6.27 days, all p < 0.001) and higher 30-day readmission rates (adjusted odds ratio ranged from 2.83 to 25.07, all p ≤ 0.001). The SSI cohort for orthopedic procedures had higher 12-month mortality (hazard ratio 1.56, p = 0.01), though other cohorts did not have significant differences. Total medical costs were higher in all three SSI cohorts vs. matched comparison cohorts for the index episode and 6 months and 1 year postdischarge. Average adjusted 1-year total medical cost differences ranged from $40,606 to $68,101 per person, depending on the cohort (p < 0.001), with out-of-pocket cost differences ranging from $330 to $860 (p < 0.05).
CONCLUSION: Patients with SSIs experienced higher LOS, readmission rates, and total medical costs, and higher mortality for some populations, compared to their matched comparison cohorts during the first year postdischarge. Identifying strategies to reduce SSIs is important both for patient outcomes and affordability of care.
BACKGROUND: Food addiction is a chronic psychological disorder resulting from repeated consumption of highly palatable foods, leading to physical and mental harm. It involves individuals who struggle to control their intake of high-energy, high-fat, and high-sugar foods, often experiencing withdrawal reactions and intense cravings that trigger binge eating during stress. Recent research has focused on the impact of food addiction on physical health, nutrition, and mental well-being. This study aims to review and analyze current evidence on food addiction to advance research in China.
METHODS: A total of 941 articles on food addiction published between January 2013 and April 2023 were analyzed using the Web of Science Core Collection. CiteSpace software was utilized to identify research trends, collaborations among disciplines, authors, and institutions, as well as key topics and emerging keywords.
RESULTS: The number of publications on food addiction has steadily increased over the past decade, with the United States leading in research output (393 articles). The University of Michigan and author Gearhardt AN were prominent contributors. Key research topics included obesity, eating disorders, addiction, and overeating. Emerging themes encompassed obesity psychology, food composition, brain function, and behavioral addiction.
CONCLUSION: Global research on food addiction primarily focuses on understanding the psychological and neurological underpinnings, metabolic implications, addictive behaviors, and treatment modalities such as sleeve gastrectomy. Future research aims to develop personalized prevention and intervention strategies for food addiction.
Cohort 3 prospective study: patients who have discontinued TKI therapy after the study approval in each center. These patients will also participate in the validation process of Phase 2 of a questionnaire developed by an expert panel of eight CML patients with the purpose of capturing the experiences of people along all phases of the TFR.
Treatment consisted of nebicapone/placebo repeated administration: one dose at 4-h intervals, for 7 full days: first dose at approximately 08 h (±1 h) on Day 1 and final dose at approximately 08 h (±1 h) on Day 8. Within each group (n=8), 2 volunteers were be randomised to receive placebo and the remaining 6 volunteers to receive nebicapone.
1,271,944. Toothpastes. BEECHAM GROUP Ltd. 7 July, 1969 [23 July, 1968], No. 35109/68. Heading A5B. Toothpastes comprise a main body which is a transparent or translucent gel and a secondary body of cleaning and polishing agents contained at least partially within the main body. The secondary body may be in the form of a core or cores surrounded by the main body or of a stripe or stripes (which may be coloured) partially contained within the main body with a portion of the surface of the stripe, (or each stripe) exposed at the surface of the main body. The main and secondary bodies preferably have rheological properties which are matched. The main body may be a gel containing water, humectant (such as glycerin, sorbitol, propylene glycol or a polyethylene glycol), detergent, e.g. sodium lauryl sulphate, sweetening agent such as saccharin, flavour (e.g. peppermint, spearment and/or aniseed oils), preservative, and thickening agent (such as carageenates, alginates, carboxyvinyl polymer, cellulose ethers and esters, or colloidal silica). The secondary body contains an abrasive such as chalk, dicalcium phosphate dihydrate, calcium pyrophosphate, alumina, polyvinyl chloride or polymethyl methacrylate. The toothpaste may also contain sodium monofluorophosphate.
[GB1271944A]
An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.
The present invention generally relates to particles, including particles for drug delivery and other applications. Certain aspects of the invention are generally directed to particles comprising a shell and an interior at least partially contained by the shell. In some embodiments, the particles may be treated to enhance the containment of the interior, for example to reduce transport of an agent into or out of the interior. Such particles may exhibit increased ability to encapsulate agents and/or increased storage life (e.g., due to reduced leakage). For instance, in certain embodiments, any defects, such as cracks, pores, etc. within the shell may be sealed or otherwise treated to reduce transport therethrough, for example, with a solid. In some embodiments, for instance, a first reactant in the interior of a particle may come into contact with a second reactant outside of the particle to form a solid, or other suitable product. The shell may also be treated, e.g., at a later point in time, to cause release of an agent contained within the interior, in certain aspects. For example, the shell may be heated to cause the release of the agent from the particle, or the shell may be exposed to chemical or enzymatic degradation, or a change in osmolarity, to cause release of an agent. Still other aspects of the present invention are generally directed to methods of making or using such particles, kits or devices including such particles, or the like.
This disclosure provides a visual analytical method of verifying dispensed pills. In a preferred embodiment, a camera captures one or more parameters of each pill as it travels along a dispense path. The camera stores the parameters, and a processor displays the parameters or evaluates whether the parameters are within a threshold limit for the dispensed pill. If the parameter is outside the threshold, the pill or the receptacle is separated and/or removed. If all the parameters are within the threshold, the pill is stored in a receptacle, and the images are processed and archived for future verification. The process is repeated for each pill in the dispenser. The system captures at least one verification image for every pill dispensed into the receptacle.
A dried venison with spleen and stomach invigorating functions and a preparation method thereof belong to the technical field of medical and meat processing. Solves the technical problems that the prior art can not remove the peculiar bitter taste and the blood fishy smell in the venison and can not prepare health-care food with certain curative effect by using the dried venison produced by the prior art. The technical scheme of the invention is as follows: the preparation components of the dried venison for invigorating spleen and stomach (by weight) are as follows: 1. 100 parts of fresh venison; 2. 0.05-1.2 of medicated leaven; 3. 0.5 to 7.2 parts of malt; 4. 0.5 to 5 of endothelium corneum Gigeriae Galli. Secondly, the preparation method of the dried venison with the functions of invigorating spleen and stomach comprises the following steps: 1. washing fresh Carnis Cervi, and cutting into pieces; 2. dehydrating fresh sliced venison at the rotation speed of 1200 rpm for 10-15 minutes at the temperature of 2-15 ℃, adjusting the dehydration time according to the temperature and the rotation speed, and keeping the venison not smelling fishy after dehydration; 3. putting the dehydrated venison, medicated leaven, malt and endothelium corneum gigeriae galli into a pot, boiling until juice is concentrated; 4. beating the cooked venison into flat pieces; 5. and (5) drying.
Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness. We employed this methodology on 16 suction blister wounds used as controls in a clinical phase-1 trial. Our method enabled us to discern and quantify subtle differences between individual wounds concerning healing progress, erythema and wound exudation. The wound healing score exhibited a high inter-rater agreement. There was a robust correlation between the spectrophotometer-measured erythema index and photography-based wound redness, as well as between dressing protein content and photography-based dressing yellowness. In conclusion, this study equips researchers conducting clinical wound studies with reproducible methods that may support future wound research and aid in the development of new treatments.
The present disclosure describes a system and method for determining cardiac parameters and physiological conditions of a user by analysing speech samples of said user. A user device of the user may record specifics of speech and use these specifics of speech as a speech sample of user's utterance. The user device may transmit the speech samples to a backend system. The system may isolate phonation segments from the speech samples. The system may filter one or more phonation segments. The system may isolate uttered speech segments from one or more phonation segments. The system may perform an acoustic-phonetic analysis of the uttered speech segments. The acoustic-phonetic analysis may use plurality of features for the analysis. The IPA phonemes may be used to derive speech markers that correspond to specific cardiac parameters and physiological conditions. The system may generate a resulting report after analysis which is transmitted to the user.
Two populations will be involved in testing in the SmarToyGym: 1. Infants exhibiting typical development between 3 months and 11 months of age 2 . Infants exhibiting atypical development (at-risk for neuromotor delay) between 3 months and 11 months of age.
The investigators plan to invite 80 children, aged 7-12 years-old who have physician-diagnosed asthma, and another age- and gender-matched children without asthma to join our study. First, obtaining clinical data of disease status, and ask participants to fill out questionnaires after recruiting. Second, participants have to record body temperature, peak expiratory flow, heart rate, finger O2 saturation percentage, asthma attack frequency continuously by care-giver every day. Third, the investigators will perform indoor environmental assessments in the subject's house, including indoor air quality, dust samples, culture for fungi and bacteria, and cockroaches. The investigators will also count the dust mites and measure phthalates concentration in every dust sample.

Then, health behavior intervention for one month will be provided to every participant. The investigators will teach children's guardians (care-giver) how to change the health behaviors to clean indoor environment, including the health behaviors in bedroom, kitchen room, restroom, refrigerator, washing machine, and incense burning hall. After 1 months, the investigators will investigate whether changing health behavior affects the exposure of phthalates, dust mites, fungi, bacteria, and cockroaches, and evaluate the effects of health behavior intervention on the clinical status of children's asthma. Children's asthma severity assessment will be recorded by ACT and also by symptomatology every day. Household health behaviors (cleaning habits) questionnaires also will be completed per week and continuously for 4 weeks.
Adenoid cystic carcinoma (ACC) is a rare tumor entity with a yearly incidence of 3-5 cases per million. ACC arises in the major salivary glands and more often in the minor salivary glands of the oropharynx, lip, nasopharynx, oral cavity, nasal cavity, paranasal sinus, larynx and tracheobronchial tree. ACC is characterized by frequent local recurrences and distant metastasis, mainly to lungs. 18F-FDG PET/CT is considered to be a viable tool to assess ACC at initial presentation. However, FDG uptake in ACC is lower than in squamous cell carcinoma (SCC) and not all ACC lesions show detectable FDG uptake. So, it is necessary to find another effective way to detect ACC and its metastases. As in known, PSMA is highly expressed in salivary glands, and Wim van Boxtel et al had demonstrated high PSMA-ligand uptake in a patient with recurrent and metastatic ACC using 68Ga-PSMA PET/CT. 68Ga-PSMA has been developed as a targeting imaging agent widely used in prostate cancer in prostate cancer. Thus, this prospective study is going to investigate whether 68Ga-PSMA PET/CT may be superior for diagnosis, therapy response assessment and follow-up of ACC than 18F-FDG PET/CT. Furthermore, peptide receptor radionuclide therapy has been widely used in the treatment of prostate cancer lesions that showed high PSMA uptake on 68Ga-PSMA PET/CT, we'll try to assess the safety and therapeutic response to 177Lu-EB-PSMA-617 in patients with ACC.
Nonalcoholic fatty liver disease (NAFLD), a disease spectrum that includes simple steatosis, nonalcoholic steatohepatitis (NASH) and cirrhosis, has been increasingly recognized as the hepatic manifestation of metabolic syndrome. Both inflammation and insulin resistance are considered to be pivotal pathogenic mechanisms of NAFLD, as well as metabolic syndrome, type 2 diabetes, and atherosclerosis. There is mounting evidence implicating adipokines secreted from adipose tissue in the pathogenesis and progression of NAFLD, in addition to the development of insulin resistance and inflammation. Selenoprotein P (SeP) has recently been reported as a novel hepatokine that regulates insulin resistance and systemic energy metabolism in rodents and humans. Although previous studies have shown a close relationship among insulin resistance, inflammation, and NAFLD, as far as we know, there is no previous report evaluating the association between SeP and NAFLD. In the present study, we examined serum SeP levels in subjects with increased visceral fat area (VFA) or liver fat accumulation measured with computed tomography (CT). We evaluated the relationship between SeP levels and cardiometabolic risk factors.
PROBLEM TO BE SOLVED: To obtain a dry medicinal herb capable of readily taking while saving a work for decoction in every times of the taking by drying a medicinal herb including water by irradiation of a far-infrared light. SOLUTION: A dry medicinal herb 21 is obtained by irradiating a far-infrared light to the medicinal herb 21 including water. Preferably, the dry medicinal herb 21 is obtained by shielding the herb 21 from the outer air by sealing, placing the herb 21 containing water in an oven filled with a wet inert gas, then dehumidifying inside of the oven to dry. A semi-dried medicinal herb 21 is charged into the oven from an opened part 3 and water is added inside the oven, then a cap is closed. Next, a valve 27 is closed while opening an exhaustion port 22 of a coagulation device 14 and a valve of a control device 13, then a gas 16 is fed into the oven, then a rotation roller 19 is rotated to rotate the oven. A heating lamp 20 is ignited and the far-infrared light is irradiated. The temperature in the oven is controlled with a thermostat 11.  The system is subjected to wet treatment and the gas dehumidified with the coagulation device 14 is fed into the oven through a fan 15 to dry the medicinal herb 21.
Pharmaceutical prepns. for treating  herpes zoster and other herpes infection contain virus titer of 5×106 to 5×108 ID50/ml and can contain the virus suspended in distd. H2O, tabletted or encapsulated, or  as an aq. -glycerin spray. Thus, an 11-yr-old girl with facial herpes zoster was administered 0.5ml of the virus-contg. nasal spray 3 times on dya 1, twice on day 2 and once on day 3. Recession of pain and scrab formation were obsd. after only 48 hr, and the scrabs fell off after 12 days instead of the usual > 32.
INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic generated considerable upheaval in all sectors of the US health care system, including maternity care. We focused this inquiry on midwifery practice leaders' experiences and perspectives on changes that occurred in their practices early in the pandemic.
METHODS: This was a qualitative descriptive study using thematic analysis. The data were responses to an open-ended question in a survey of pandemic-related employment and clinical practice changes. Findings are presented from a constructivist perspective, describing the experiences and perspectives of a group of US midwifery practice leaders during the initial phase of the COVID-19 pandemic.
RESULTS: Two main themes emerged from the analysis: demands on midwives and driving forces. Demands on midwives were 3-fold: clients' needs, modification of care, and midwives' needs. These encompassed the psychological, physical, and emotional toll that caring for women during the pandemic placed on midwives. Driving forces were those entities that spurred and directed change and included regulations, institutions, financial logistics, and team dynamics. Survey respondents in community (home and birth center) practices reported substantial increases in inquiries and client volume, and many respondents expressed concern about withdrawal of students from clinical placements.
DISCUSSION: Midwifery practices experienced profound changes in their work environments during the COVID-19 pandemic, with both positive and negative characteristics. These challenges in providing birth care were similar to those reported in other countries. Results indicated existing guidance for maternity care during emergencies did not meet clients' needs. Coordinated planning for maternity care in future prolonged health emergencies should incorporate best practices and include midwives in the process.
A gelatin-based (e.g., gelatin methacryloyl (GelMA)) patch is disclosed with an array of microneedles (MNs) for minimally invasive sampling of bodily fluids such as interstitial fluid (ISF). The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time. The GelMA-based MN patch demonstrated efficient extraction of ISF. Furthermore, in experimental testing, the patch efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA microneedle enables to detection and analysis of target molecules from patients. The target molecules captured in the patch may be released and analyzed to detect the presence of and/or concentration of target molecules. In other embodiments, the patch itself may be analyzed directly to detect the presence of and/or concentration of target molecules.
OBJECTIVE: Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon response. Using a large single-center IESS cohort, we set out to quantify the risk of epileptic spasms relapse and identify specific risk factors.
METHODS: We identified all children with epileptic spasms at our center using a clinical EEG database. Using the electronic medical record, we confirmed IESS syndrome classification and ascertained treatment, response, time to relapse, etiology, EEG features, and other demographic factors. Relapse-free survival analysis was carried out using Cox proportional hazards regression.
RESULTS: Among 599 children with IESS, 197 specifically responded to hormonal therapy and/or vigabatrin (as opposed to surgery or other second-line treatments). In this study, 41 (21%) subjects exhibited relapse of epileptic spasms within 12 months of response. Longer duration of IESS prior to response (>3 months) was strongly associated with shorter latency to relapse (hazard ratio = 3.11; 95% CI 1.59-6.10; p = 0.001). Relapse was not associated with etiology, developmental status, or any post-treatment EEG feature.
SIGNIFICANCE: This study suggests that long duration of IESS before response is the single largest clinical predictor of relapse risk, and therefore underscores the importance of prompt and successful initial treatment. Further study is needed to evaluate candidate biomarkers of epileptic spasms relapse and identify treatments to mitigate this risk.
PLAIN LANGUAGE SUMMARY: Relapse of infantile spasms is common after initially successful treatment. With study of a large group of children with infantile spasms, we determined that relapse is linked to long duration of infantile spasms. In contrast, relapse was not associated with the cause of infantile spasms, developmental measures, or EEG features at the time of initial response. Further study is needed to identify tools to predict impending relapse of infantile spasms.