anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sleep insufficiency is a significant health problem worldwide, and adolescent sleep restriction (SR) could induce multiple neurodevelopmental disorders in the central nervous system (CNS). Microglial-mediated neuroinflammation plays a vital role in multiple neurological diseases, and recent research showed the regulation effect of immunoproteasome on microglia functions. Geraniol (GER), an important ingredient in many essential oils, possesses diverse pharmacological properties like anti-inflammatory and antioxidant. The present study was designed to evaluate the neuroprotective effect of GER on SR in adolescent mice and further investigate the underlying mechanisms. Our results displayed that 14 days of chronic sleep restriction (CSR) induced cognitive decline, and anxiety-like and attention-deficit behaviors, which were mitigated by GER pretreatment. GER administration also reversed microglial pro-inflammatory response under CSR stimulation in the anterior cingulate cortex (ACC) regions by reducing the expression and secretion of cytokines like IL-1β and TNF-α. Mechanism research showed that LMP7 mRNA was selectively up-regulated under CSR treatment but down-regulated by GER administration. Proteasome activity and protein expression of LMP7 were consistent with mRNA data. ONX-0914 was applied to inhibit LMP7 selectively, and data validated that GER might alleviate CSR-induced neuroinflammation by regulating LMP7. Our study provides evidence that LMP7 is a critical regulator of CSR-induced proinflammation, and geraniol might be a promising therapy against CSR-induced neurodevelopmental disorders.
The invention discloses a natural product composition used for reducing blood fat and a preparation method thereof. The basic components of the composition are opuntia milpa alta, functional red infested rice and silymarin. The opuntia milpa alta is prepared into refined dry powder. The ratio of the opuntia milpa alta refined dry powder to the functional red infested rice to the silymarin is 300-600g:30-100g:30-80g. The opuntia milpa alta is prepared into an ethanolic extract. The ratio of the opuntia milpa alta ethanolic extract to the functional red infested rice to the silymarin is 300-100g:30-100g:30-80g. The composition can be used for preparing foods, medicaments and health-care products which have the functions of reducing blood fat and blood sugar, improving immunity, preventing cardiovascular and cerebrovascular diseases and removing fatty liver.
OBJECTIVE: Acute pericoronitis (AP) is a prevalent cause of odontogenic toothache which can significantly impact brain function. Previous research has predominantly concentrated on localized brain activity. However, the synergistic changes between brain hemispheres induced by toothache and resulting abnormal functional connectivity across the brain have not been comprehensively studied.
METHODS: A total of 34 patients with AP and 34 healthy individuals, matched for age, sex, and education were recruited for this study. All participants underwent resting-state functional magnetic resonance imaging (rs-MRI) scans. The voxel mirror homotopic connectivity (VMHC) method was used to identify intergroup differences. Brain regions exhibiting statistically significant differences were selected as regions of interest for further functional connectivity analysis. The partial correlation method was utilized to assess the correlation between abnormal VMHC values in different regions and clinical parameters, with age and sex included as covariates.
RESULTS: Patients with AP exhibited reduced VMHC values in the thalamus and elevated VMHC values in the inferior frontal gyrus compared with healthy controls. Subsequent functional connectivity analyses revealed extensive changes in functional networks, predominantly affecting the default, frontoparietal, cerebellar, and pain networks.
CONCLUSION: Changes in functional patterns across these brain networks offer novel insights into the neurophysiological mechanisms underlying pain information processing.
BACKGROUND: Lung cancer is the second most common cancer with the highest mortality in the world. Calumenin as a molecular chaperone that not only binds various proteins within the endoplasmic reticulum but also plays crucial roles in diverse processes associated with tumor development. However, the regulatory mechanism of calumenin in lung adenocarcinoma remains elusive. Here, we studied the impact of calumenin on lung adenocarcinoma and explored possible mechanisms.
METHODS: 5-ethynyl-2'-deoxyuridine assay, colony formation, transwell and wound healing assays were performed to explore the effects of calumenin on the proliferation and migration of lung adenocarcinoma cells. To gain insights into the underlying mechanisms through which calumenin knockdown inhibits the migration and proliferation of lung adenocarcinoma, we performed Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Gene Set Enrichment Analysis and Ingenuity Pathway Analysis based on transcriptomics by comparing calumenin knockdown with normal A549 cells.
RESULTS: The mRNA and protein levels of calumenin in lung adenocarcinoma are highly expressed and they are related to an unfavorable prognosis in this disease. Calumenin enhances the proliferation and migration of A549 and H1299 cells. Gene Set Enrichment Analysis revealed that knockdown of calumenin in A549 cells significantly inhibited MYC and V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog signaling pathways while activating interferon signals, inflammatory signals, and p53 pathways. Ingenuity pathway analysis provided additional insights, indicating that the interferon and inflammatory pathways were prominently activated upon calumenin knockdown in A549 cells.
CONCLUSIONS: The anti-cancer mechanism of calumenin knockdown might be related to the inhibition of MYC and KRAS signals but the activation of interferon signals, inflammatory signals and p53 pathways.
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease. Although murine studies have demonstrated that type 2 innate lymphoid cells (ILCs) mediate type 2 skin inflammation, their role in skin fibrosis in AD remains unclear. This study investigated whether type 2 ILCs are involved in skin fibrosis using an AD-like murine model.
METHODS: C57BL/6 mice were treated epicutaneously with Aspergillus fumigatus (Af) for 5 consecutive days per week for 5 weeks to induce skin fibrosis. Mature lymphocyte deficient Rag1-/- mice were also used to investigate the role of type 2 ILCs in skin fibrosis.
RESULTS: The clinical score and transepidermal water loss (TEWL) were significantly higher in the AD group than in the control group. The AD group also showed significantly increased epidermal and dermal thicknesses and significantly higher numbers of eosinophils, neutrophils, mast cells, and lymphocytes in the lesional skin than the control group. The lesional skin of the AD group showed increased stain of collagen and significantly higher levels of collagen than the control group (10.4 ± 2.2 µg/mg vs. 1.6 ± 0.1 µg/mg, P < 0.05). The AD group showed significantly higher populations of type 2 ILCs in the lesional skin compared to the control group (0.08 ± 0.01% vs. 0.03 ± 0.01%, P < 0.05). These findings were also similar with the AD group of Rag1-/- mice compared to their control group. Depletion of type 2 ILCs with anti-CD90.2 monoclonal antibodies significantly improved clinical symptom score, TEWL, and infiltration of inflammatory cells, and significantly decreased levels of collagen were observed in the AD group of Rag1-/- mice (1.6 ± 0.0 μg/mg vs. 4.5 ± 0.3 μg/mg, P < 0.001).
CONCLUSION: In the Af-induced AD-like murine model, type 2 ILCs were elevated, with increased levels of collagen. Additionally, removal of type 2 ILCs resulted in decreased collagen levels and improved AD-like pathological findings. These findings suggest that type 2 ILCs play a role in the mechanism of skin fibrosis in AD.
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is the standard of care for secondary prevention after percutaneous coronary intervention (PCI). DAPT has demonstrated its efficacy in reducing ischemic complications (including stent thrombosis) after PCI although at the cost of an increased risk of bleeding. As both event types have been independently linked with excess morbidity and mortality, international guidelines emphasize the need to tailor DAPT duration and intensity according to the individual ischemic and bleeding risk profile of each patient. In this context, several predictive risk models for bleeding and thrombosis have been developed with the aim of guiding clinical decisions on DAPT management post-PCI. However, many of these risk models have shown only modest performance and limited applicability in real-world clinical practice. Such limitations can be attributed, at least in part, to the analytical approaches used for their development, mostly based on linear models unable to capture the complex interplay between different clinical covariates. Machine learning methods offer the potential to overcome these limitations by leveraging computer algorithms to large datasets that capture high-dimensional, non-linear relationships among variables. However, the feasibility and usefulness of machine learning-based prognostic risk models in PCI patients remain relatively unexplored.

The present study will analyze data from 11 clinical trials encompassing approximately 19,000 patients undergoing percutaneous coronary intervention (PCI) with an everolimus-eluting stent to develop a machine learning-based algorithm. Institutional review board approval or informed patient consent was not required as this study is an analysis of previously published clinical trials and all individual patient data were deidentified. The goal is to predict the probability of an ischemic or bleeding event up to 1 year after PCI. Patient-level data from the eligible clinical trials listed per the XIENCE Machine Learning Data Acquisition Protocol (90961902) will be pooled and randomly split into a training cohort (\~75%) and a validation cohort (\~25%). These include both Abbott- sponsored and investigator-initiated XIENCE studies (i.e., XIENCE V, XIENCE 28 USA, XIENCE 28 GLOBAL, XIENCE 90, ABSORB III, ABSORB IV, Compare ABSORB, Compare Acute, EXAMINATION, SIERRA-75 and ITALIC). The performance of different trials of machine learning classifiers will be compared with traditional statistical approaches for the prediction of ischemic and bleeding outcomes. The best-performing machine learning model will then be selected and tested against a pre-defined performance goal to assess its clinical usefulness. Based on existing literature on established risk scores that currently inform clinical practice, the performance goal for the model is set at C-index value equal or greater than 0.65 at the 97.5% lower confidence interval of the bootstrap C-index distribution. This is to ensure that the true value of the C-index is still within a clinically relevant range and to validate the clinical usefulness of the risk prediction model.
The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of  Leishmania , said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of  Leishmania  coding for an excretion/secretion antigen.
Neuroinflammation, triggered by aberrantly activated microglia, is widely recognized as a key contributor to the initiation and progression of Alzheimer's disease (AD). Microglial activation in the central nervous system (CNS) can be classified into two distinct phenotypes: the pro-inflammatory M1 phenotype and the anti-inflammatory M2 phenotype. In this study, we investigated the effects of a non-invasive rotating magnetic field (RMF) (0.2T, 4Hz) on cognitive and memory impairments in a sporadic AD model of female Kunming mice induced by AlCl3 and D-gal. Our findings revealed significant improvements in cognitive and memory impairments following RMF treatment. Furthermore, RMF treatment led to reduced amyloid-beta (Aβ) deposition, mitigated damage to hippocampal morphology, prevented synaptic and neuronal loss, and alleviated cell apoptosis in the hippocampus and cortex of AD mice. Notably, RMF treatment ameliorated neuroinflammation, facilitated the transition of microglial polarization from M1 to M2, and inhibited the NF-кB/MAPK pathway. Additionally, RMF treatment resulted in reduced aluminum deposition in the brains of AD mice. In cellular experiments, RMF promoted the M1-M2 polarization transition and enhanced amyloid phagocytosis in cultured BV2 cells while inhibiting the TLR4/NF-кB/MAPK pathway. Collectively, these results demonstrate that RMF improves memory and cognitive impairments in a sporadic AD model, potentially by promoting the M1 to M2 transition of microglial polarization through inhibition of the NF-кB/MAPK signaling pathway. These findings suggest the promising therapeutic applications of RMF in the clinical treatment of AD.
The invention provides the property of cerebrovascular diseases, a method for checking a plurality of instruments with correct symptoms, a medicament treatment formula, in particular to a medicament composition for intravenous drip. Consists of: the intravenous drip is continuously dripped once a day until the adult heals. The dosage for each time of adults is as follows: 1. 100 mg of 5 pieces of thrombus powder, and 250 g of 0.9% physiological saline. 2. Breviscapine (lyophilized) powder 25 mg × 2 pieces, and 0.9% physiological saline 250 g. 3. Radix salviae miltiorrhizae needle: 10 ml of the solution is added with 250 g of 0.9% physiological saline. Used in the order of 1, 2, 3. The dripping is finished in about 3 hours. It is reduced properly before the age of 18 years. Patients with mild cervical spondylosis: the disease is cured after 3 to 7 days. Severe patients are older. At the same time, the cerebrovascular symptoms are obviously relieved. Because the cervical spondylosis belongs to cerebrovascular diseases, the treatment of the cervical spondylosis is not expensive. (because of being a combination of treatment).
French medical students have benefited from a new evaluation method since 2020 in the form of a standardized objective clinical examination (OSCE). This examination consists of an evaluation of an initial clinical situation, in relation to a pre-identified and nationally identical objective in all Medical School. During these exams, the student has one minute of preparation then seven minutes of evaluation in front of a facilitator, member of the teaching staff. An examiner is also present in the room to search in real time for keywords intended for grading. The examiner and facilitator may or may not be tenured teachers. Students benefit from annual training organized by the Medical School of Clermont-Ferrand in which they all participate. This exam appears to be excessively stressful for students. However, there is currently no data regarding the objective measurement of the stress of these students. Heart rate variability is a biomarker of stress measured with a simple heart rate monitor or a watch, completely painless, non-intrusive, and used by the general public routinely in many areas (monitoring sports sessions, etc...).
Cerebrovascular pathology often co-exists with Alzheimer's disease pathology and can contribute to Alzheimer's disease-related clinical progression. However, the degree to which vascular burden contributes to Alzheimer's disease pathological progression is still unclear. This study aimed to investigate interactions between vascular burden and amyloid-β pathology on both baseline tau tangle load and longitudinal tau accumulation. We included 1229 participants from the Swedish BioFINDER-2 Study, including cognitively unimpaired and impaired participants with and without biomarker-confirmed amyloid-β pathology. All underwent baseline tau-PET (18F-RO948), and a subset (n = 677) underwent longitudinal tau-PET after 2.5 ± 1.0 years. Tau-PET uptake was computed for a temporal meta-region-of-interest. We focused on four main vascular imaging features and risk factors: microbleeds; white matter lesion volume; stroke-related events (infarcts, lacunes and haemorrhages); and the Framingham Heart Study Cardiovascular Disease risk score. To validate our in vivo results, we examined 1610 autopsy cases from an Arizona-based neuropathology cohort on three main vascular pathological features: cerebral amyloid angiopathy; white matter rarefaction; and infarcts. For the in vivo cohort, primary analyses included age-, sex- and APOE ɛ4-corrected linear mixed models between tau-PET (outcome) and interactions between time, amyloid-β and each vascular feature (predictors). For the neuropathology cohort, age-, sex- and APOE ɛ4-corrected linear models between tau tangle density (outcome) and an interaction between plaque density and each vascular feature (predictors) were performed. In cognitively unimpaired individuals, we observed a significant interaction between microbleeds and amyloid-β pathology on greater baseline tau load (β = 0.68, P < 0.001) and longitudinal tau accumulation (β = 0.11, P < 0.001). For white matter lesion volume, we did not observe a significant independent interaction effect with amyloid-β on tau after accounting for microbleeds. In cognitively unimpaired individuals, we further found that stroke-related events showed a significant negative interaction with amyloid-β on longitudinal tau (β = -0.08, P < 0.001). In cognitively impaired individuals, there were no significant interaction effects between cerebrovascular and amyloid-β pathology at all. In the neuropathology dataset, the in vivo observed interaction effects between cerebral amyloid angiopathy and plaque density (β = 0.38, P < 0.001) and between infarcts and plaque density (β = -0.11, P = 0.005) on tau tangle density were replicated. To conclude, we demonstrated that cerebrovascular pathology-in the presence of amyloid-β pathology-modifies tau accumulation in early stages of Alzheimer's disease. More specifically, the co-occurrence of microbleeds and amyloid-β pathology was associated with greater accumulation of tau aggregates during early disease stages. This opens the possibility that interventions targeting microbleeds may attenuate the rate of tau accumulation in Alzheimer's disease.
Participants receive leuprolide acetate, goserelin acetate, degarelix, bicalutamide, flutamide, or nilutamide as in Arm A. Patients also receive abiraterone acetate PO daily for 8 months and prednisone daily. Patients may crossover to Arm A with disease progression after 8 months.
Kinin receptors B1 and B2 are involved in migration and invasion in gastric, glioma, and cervical cancer cells, among others. However, the role of kinin receptors in breast cancer cells has been poorly studied. We aimed to reveal the impact of B1 and B2 receptors on migration and invasion in breast cancer cells and demonstrate their capacity to modulate in vivo tumor growth. MDA-MB-231, MCF-7, and T47D cells treated with Lys-des[Arg9]bradykinin (LDBK) or bradykinin (BK) were used to evaluate migration and invasion. Des-[Arg9]-Leu8-BK and HOE-140 were used as antagonists for the B1 and B2 receptors. MDA-MB-231 cells incubated or not with antagonists were subcutaneously inoculated in BALBc NOD/SCID mice to evaluate tumor growth. LDBK and BK treatment significantly increased migration and invasion in breast cancer cells, effects that were negated when antagonists were used. The use of antagonists in vivo inhibited tumor growth. Moreover, the migration and invasion induced by kinins in breast cancer cells were inhibited when focal adhesion kinase (FAK) and Src inhibitors were used. The novelty revealed in our work is that B1 and B2 receptors activated by LDBK and BK induce migration and invasion in breast cancer cells via a mechanism that involves the FAK-Src signaling pathway, and the antagonism of both receptors in vivo impairs breast tumor growth.
PURPOSE:To readily obtain the subject preparation having a simple composition and capable of controlling elusion of a medicine. CONSTITUTION:In a preparation composed of a medicine exhibiting a pH- dependent solubility and a porous. cellulose, elusion of the medicine is controlled by supporting an acid or a base on the porous cellulose. The preparation may be carried out by supporting the medicine and an acid or a base on the porous cellulose or by using a coating film containing the medicine and an acid or a base. The composition for pharmaceutical preparation obtained by supporting an acid or a base on the porous cellulose is useful for controlling elusion of the medicine. The preparation may contain an additive such as a binder. A solid preparation such as powder, granule, tablet or capsule can be used as the dosage form.
As a herbal remedy to asthma the invention is composed of weighed proportional mixture of Sunnut honey and powder of grounded seeds of Solatium, dubium. Phytochcmical analysis was performed on the crude extracts of the seeds, honey and their combination. Separation and isolation of active compounds from the methanolic extract of combination was carried out using bioassay-guided fractionation. Fractionation and isolation of the active ingredients of the methanolic extract were performed by Column Chromatography (monitored by TLC and PTLC). Nuclear magnetic resonance (NMR), mass spectrometry (MS), ultraviolet (UV) and infrared (IR) spectrometry were used for structure elucidation of the isolated compounds. The in-vivo experiments implemented are to assess the toxicological study of the crude and methanolic extracts of the combination, honey and the seeds on (96 )Wister Albino rats using the acute toxicity (Ll½ percentage) done on 7- days and sub-chronic for 28 days. The results revealed that there is no acute or sub-chronic toxicity displayed by the different concentrations of the extracts, The method of Carrageenan induced paw oedem in (162) Wister Rats was done to evaluate the anti-inflammatory effects of aqueous crude extract of S. dubuim seeds, honey and combination. The results showed that all ingredients were found to have a significant anti inflammatory activity on paw edema volume. Also the result of methanolic extracts showed a significant inhibition of inflammation. The results of the anti-inflammatory activity of the fractions of methanolic extract, five fractions showed a significant inhibition of inflammation over the other alcoholic fraction extracts. Also all fractions decreased rat paw edema. The bronchodilator activities of aqueous crude extract of the three ingredients was done using in vitro studies on isolated tracheal preparations of Guinea pigs and Guinea pigs pattern of allergic asthma setup experiment. The results of bronchodilator activities, the animal of control group, prior administration of the combination, lmg/ml partially blocked the contracting effect of histamine 100 nano g/ml on isolated tracheal spirally cut strip. The S. dubuim seeds extract alone produced further transient stimulant effect followed by persistent relaxant effect on histamine contracting effect on isolated guinea pigs tracheal strip. In animals of sensitized group, the combination and seeds extract lmg/ml relaxed effectively the stimulant effect of the guinea pigs tracheal strip. The relaxant effect of the combination was completely blocked by propranolal. The sensitized and treatment subgroups, both honey and combination antagonized the contracting effect of histamine 100 nano g/ml on guinea pigs tracheal strip, As a clinical trial for the combined ingredients, twenty five patients medically diagnosed as asthmatic were randomly selected and enrolled in the study; none of them is currently using anti-asthmatic drugs. Signs of asthma disappeared in the treated patients.