anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIMS AND OBJECTIVES: Myalgic encephalomyelitis (ME), also called chronic fatigue syndrome (CFS), is characterised by persistent fatigue, postexertional malaise, and cognitive dysfunction. It is a complex, long-term, and debilitating illness without widely effective treatments. This study describes the treatment choices and experiences of ME/CFS patients who have experienced variable levels of recovery.
METHOD: Interpretive description study consisting of semi-structured qualitative interviews with 33 people who met the US Centers for Disease Control (2015) diagnostic criteria for ME/CFS and report recovery or symptom improvement.
RESULTS: Twenty-six participants endorsed partial recovery, and seven reported full recovery from ME/CFS. Participants reported expending significant time and energy to identify, implement, and adapt therapeutic interventions, often without the guidance of a medical practitioner. They formulated individualised treatment plans reflecting their understanding of their illness and personal resources. Most fully recovered participants attributed their success to mind-body approaches.
CONCLUSION: Patients with ME/CFS describe independently constructing and managing treatment plans, due to a lack of health system support. Stigmatised and dismissive responses from clinicians precipitated disengagement from the medical system and prompted use of other forms of treatment.
These study patients will be consented by members of the research team prior to surgery at their pre-operative clinic visit. The patient will receive RT or RN education preoperatively as to the importance of incentive spirometry in prevention of post-operative respiratory complications. This subgroup will be provided with a digital incentive spirometer connected to a tablet interface. This tablet device uses a digital interface to mimic the look and function of the standard issue incentive spirometer, and will set a spirometry goal while collecting usage and pulmonary function data. Subjects in this group will also receive daily intensive education from a study team member during the postoperative time up until 72 hours or until discharge.
Platelet therapy is quickly becoming an integral aspect of both medical and cosmetic procedures. Most notably, Platelet Rich Plasma (PRP) has been used in surgical settings to stimulate healing and promote tissue regeneration. In the field of cosmetic medicine, PRP has been used topically or as an injection to stimulate collagen production and enhance the efficacy of cosmetic procedures such as fat transfer, hair loss therapies, laser treatments, and microneedling. Harvested PRP has platelets, fibrin, and white blood cells, which contribute to wound healing, neocollagenesis, and elastogenesis. Platelet Rich Fibrin (PRF) is the next generation of PRP and contains very high concentrations white blood cells, fibrin and a small amount of mesenchymal stem cells found circulating in our bloodstreams. Due to a lack of anticoagulant in the tube, PRF becomes a gel after 15-20 minutes of being isolated. These properties make PRF useful in reconstructive and aesthetic medicine but may also be beneficial for scar therapy in the same way PRP is currently used.The purpose of this study is to evaluate the efficacy of platelet rich plasma vs. platelet rich fibrin for scar therapy in abdominoplasty who are at least one-year post operation.
The invention relates to a chitosan bubble bath for curing gynecological diseases and a preparation method thereof. The bubble bath mainly comprises the following components: chitosan, manno-oligosaccharides, benzalkonium chloride, aloe, oil of zedoary turmeric, triclosan, NPE, coconut oil base CMEA, polyethyleneglycol 400, sodium dodecyl sulfate, ammonium lauryl sulfate, tween, trolamine, purified water, butane, etc. The chitosan bubble bath is a novel gynecological medicine which is non-toxic, safe and degraded. The invention has the advantages of pure antibiotic activity, wide antimicrobial spectrum and prominent bacteriostasis effect on gram-positive bacteria, Gram-negative bacteria and Candida albicans. The chitosan bubble bath has the characteristics of innocuity, biodegradability (can be degraded by multiple enzyme biology such as muramidase, pepsin, and the like, in a body; the degradation products are nontoxic and can be fully absorbed by organism), good biocompatibility, film formation, etc. The chitosan bubble bath has the special functions of strengthening immunity, moistening and promoting the growth of epidermis, accelerating tissue repair, etc.
Vehicle-assisted ligature strangulation is an extremely rare suicide method. We report a case of a 43-year-old man who secured one end of a nylon rope to a tree and the other end around his neck, then got inside his vehicle and stepped on the gas, leading to an incomplete decapitation. A sharply demarcated encircling ligature mark was found upon external examination, along with a deep laceration in the anterior region of the neck. The severance plane passed between the third and fourth cervical vertebrae, with diffuse haemorrhagic infiltration of the cervical muscles, in accordance with autopsy findings reported in the literature. The lung histological examination described a large amount of red blood cells and pulmonary oedema. A review of the literature concerning suicidal vehicle-assisted ligature strangulation cases allowed us to investigate some common autopsy findings, as well as the rope features relevant to the beheading.
The present device is a microchannel separator that uses a separation driving force created by an electric field. An ionic fluid flows through the microchannels and is subjected to an electric field by two spaced apart parallel electrodes possessing an electric charge. The ions in the ionic fluid are attracted towards the charged electrodes and thus are concentrated in the region of flow near the charged electrodes and depleted from the central region of flow between the charged electrodes. The charged electrodes are insulated from the ionic fluid by an impermeable barrier which prevents arcing and adherence of the ions to the charged electrodes. After a sufficient length of passage of the ionic fluid through a main channel, two blocking plates separate the flow into a central and two outer output channels. The central channel draws a portion of the ionic fluid from the central region of the main channel that has fewer ions than the ionic fluid in the regions near the charged electrodes. The concentrated ionic fluid in the outer channels is discharged separately from the central channel.
Prospective cohort of patients undergoing laparoscopic inguinal hernia repair will receive Sugammadex. Sugammadex will be used for reversal of their neuromuscular blockade. The dosing for Sugammadex is 4mg/kg for a deep reversal and a 2mg/kg for a standard reversal, which will be more common for this study. Sugammadex comes in 200mg/2mL and 500mg/5mL vials. Because of the variability in weight of the patients and the type of reversal needed (deep vs standard), 140 5mL vials will be required.
This app allows user to search for a snack (scan barcode or type snack name), add a portion size consumed based on a portion size guide, and then provide a snack score and breakdown scores with a specific feedback message about the score.25 A score ranging from 0-10 points was designed taking into account the first ingredient, the nutrient standard by portion size, and the processing of foods (score ranging from -1 to 1 was subtracted or added depend on processed food classification). The final score ranged from -1 to 11 points. The higher the score, the more compliant it is to the guideline; therefore, the healthier the snack is. The app also provides gamification features as self-motivation (level up and achievement gained) and reporting features as goal-setting and self-monitoring (average daily score and consumed snack history).
Topical formulations containing one or more pharmaceutically acceptable bioadhesive film-forming agent, one or more anti-acne agent, and an aqueous solvent in the form of a solution or suspension are described herein. The formulation may further contain one or more excipients, including evaporation suppressants, humectants, or plasticizers. When the formulation is contacted with the skin of a patient, the solvent evaporates and forms a thin, transparent, and solid bioadhesive film. The bioadhesive film adheres to the skin surface for a prolonged period of time and the anti-acne agent is released into the skin over a prolonged period of time. Typically, the bioadhesive film adheres to the skin for at least 60 minutes following administration of the formulation, preferably for at least 8 hours following administration, more preferably up to 24 hours following administration. The prolonged retention of the anti-acne agent at the site increases the amount of uptake into the skin.
The present invention relates to a foot bath hypotensor. Both feet are fumigated by traditional Chinese medicine soup which is boiled, and hands and the feet are immersed by the traditional Chinese medicine soup. The present invention comprises 5 to 8 parts of buck grass, 1 to 1.5 part of grass of meadow rue, 2 to 3 parts of hairy holly roots, 2 to 3 parts of field thistle, 2 to 3 parts of wolfberry bark, 1 to 2 parts of acanthopanax bark, 0.7 to 1.2 part of arctium fruit, 0.6 to 1.0 part of plantain seed, 0.1 to 0.2 part of radix achyranthis bidentatae, 0.2 to 0.3 part of frying fleece-flower root, and 0.2 to 0.4 part of broomrape. The present invention has reasonable recipe and has the functions for dredging channels, enhancing softness and elasticity of blood vessels, changing blood pressure and promoting blood circulation. The normal cycle of a heart is restored, and simultaneously, the liver and the kidney can be nourished. The present invention can be used for treating hypertension and reducing blood fat. The present invention can also be used for excessive internal heat removal, catharsis, diuresis, expulsion of toxin, etc.
The invention provides an anti-intoxication, alcohol-expelling and liver-protection preparation which has the functions of anti-intoxication, alcohol-expelling and auxiliary protection on alcoholic liver injury. The preparation consists of the following raw materials: 20-50 parts of vine tea, 5-15 parts of galangal, 10-40 parts of mung beans and 10-40 parts of poria cocos. The vine tea contains a great amount of flavonoid substances, and the dihydromyricetin in the vine tea has special effects in removing toxicity in alcohol, preventing alcoholic liver and fatty liver, inhibiting liver cell deteriorate, reducing the morbidity of liver cancer and protecting the liver. The galangal is acrid and hot in property, can enter the spleen and stomach channels, has the functions of eliminating cold to stop pain and warming the middle energy and stopping throwing and has a certain alcohol-expelling function, and moreover the flavonoid substance galangin in the galangal has a protection function on acute alcoholic liver injury. The poria cocos has the effects of clearing damp and promoting dieresis, tonifying spleen and quieting the heart, can promote the alcohol in bodies to discharge out along with urine, and is beneficial to sobering up. The mung beans have the effect of clearing away heat and toxic materials, can effectively relieve the symptoms of dizziness and unclear speaking after drinking alcohol, and furthermore has the pharmacologic action of protecting the liver and the kidney.
The present invention relates to a method for preparing soymilk powder with composite micron pollen pine and konjak for reducing weight and lowering blood sugar. Various kinds of traditional soymilk powder are added with micron konjak powder, micron pine pollen, micron bee pollen, micron poria powder, glucomannan powder and xylitol powder which are crushed into ultrafine powder by high-tech air stream, all kinds of raw material are combined and processed, and the soymilk powder for reducing weight and lowering blood sugar is obtained. The soymilk powder has the obvious functions for reducing weight and lowering blood sugar, and simultaneously, the soymilk powder has the efficiency for eliminating toxicant, servicing beauty, enhancing immunity, etc. Fat hyperglycemia persons can obtain hundreds of kinds of nutrient substances, such as rich vitamins, minerals, active ferments, etc. Simultaneously, because the micron pine pollen, the micron konjak powder, etc. which are called as a jewelry for facial beautification, reducing weight, and servicing beauty in the east are added, the soymilk powder is good for digestive absorption by a human body, and the health care effect on reducing weight, lowering blood sugar, eliminating toxicant and servicing beauty is intensified. Therefore, the soymilk powder prepared by the present invention is a good soymilk powder product for reducing weight and lowering blood sugar. The soymilk powder is especially designed for fat hyperglycemia persons all over the world and has the Chinese characteristics.
Autism is a condition that affects brain development, often leading to difficulties in social, emotional, and educational functioning. This study will determine whether early intervention can improve such functioning in toddlers with autism.

Each treatment session will last 6 months. Children with an autism spectrum disorder will be enrolled in one of two parallel classes and will receive one of two treatments 4 days a week for the duration of the session. Children in each class will receive the same amount and level of intervention, but with a different goal focus. Treatments will be school- and home-based; parents will receive instruction on administering the at-home part of the treatment. The intervention will include environmental engineering, developmental approaches, adaptations of traditional behavioral approaches, and contemporary behavioral approaches that apply principles of applied behavior analysis in more naturalistic teaching frameworks. A series of measures including scales, interviews, and observations will be used to assess the children at baseline, study completion, and 6 months after study completion. The children will be videotaped during the school-based intervention.
RATIONALE: Kawasaki disease (KD) is a vasculitis syndrome of small to medium-sized arteries that has typical clinical characteristics such as fever, rash, cervical lymphadenopathy, conjunctivitis, and mucosal changes. Cardiac manifestations, including coronary artery aneurysms, myocarditis, myocardial infarction, and sudden cardiac death, are the most serious complications observed in KD. On rare occasions, it may accompanied with reduced organ perfusion due to systolic hypotension, a condition known as Kawasaki disease shock syndrome (KDSS). KDSS is a serious complication that can be presented to the emergency department as an initial feature when typical clinical symptoms of KD have not be detected.
PATIENT CONCERNS: We report the case of a 12-year-old boy admitted with prolonged fever, bilateral non-purulent conjunctivitis, and signs of shock such as hypotension and tachycardia. Laboratory findings showed elevated inflammatory markers, hypoalbuminemia, and sterile pyuria. He was initially treated with intravenous cefotaxime and vancomycin considering the possible diagnosis of toxic shock syndrome, while the treatment was not effective. Subsequent chest computerized tomography and ultrasound identified pulmonary consolidation and polyserous effusion. Echocardiography revealed mild biatrial dilatation and mild valvular regurgitation with preserved left ventricular function.
DIAGNOSIS: After a multidisciplinary consultation, a diagnosis of KDSS was made.
INTERVENTIONS: To prevent coronary artery lesions and other severe complications, the patient immediately received immunoglobulin, corticoid, and acetylsalicylic acid.
OUTCOMES: Soon afterwards, he showed significant improvement, with the temperature dropped to normal and hypotension corrected about 24 hours post-intravenous immunoglobulin therapy. Polyserous effusions also disappeared before discharge. Follow-up echocardiography revealed normal results.
LESSONS: Clinicians should maintain a high index of suspicion for KD and consider pulmonary involvement and polyserous effusions as potential complications. For children with KD, any symptoms pointing to infection should be carefully considered. When there is no etiologic evidence, antibiotics should be used with caution. Our case also highlights the importance of considering KDSS as a differential diagnosis in children presenting with prolonged fever and shock. Early recognition, timely treatment, and close monitoring are key to preventing severe complications and ensuring favorable outcomes in patients with KDSS.
Presbycusis is characterized by high-frequency hearing loss and is closely associated with cognitive decline. Previous studies have observed functional reorganization of gray matter in presbycusis, but the information transmission between gray matter and white matter remains ill-defined. Using resting-state functional magnetic resonance imaging, we investigated differences in functional connectivity (GM-GM, WM-WM, and GM-WM) between 60 patients with presbycusis and 57 healthy controls. Subsequently, we examined the correlation between these connectivity differences with high-frequency hearing loss as well as cognitive impairment. Our results revealed significant alterations in functional connectivity involving the body of the corpus callosum, posterior limbs of the internal capsule, retrolenticular region of the internal capsule, and the gray matter regions in presbycusis. Notably, disrupted functional connectivity was observed between the body of the corpus callosum and ventral anterior cingulate cortex in presbycusis, which was associated with impaired attention. Additionally, enhanced functional connectivity was found in presbycusis between the internal capsule and the ventral auditory processing stream, which was related to impaired cognition in multiple domains. These two patterns of altered functional connectivity between gray matter and white matter may involve both bottom-up and top-down regulation of cognitive function. These findings provide novel insights into understanding cognitive compensation and resource redistribution mechanisms in presbycusis.
To investigate the efficacy of precise radiation therapy for lymphatic drainage area prevention (ENI) and invasive field irradiation (IFI) in patients with esophageal cancer undergoing radical radiotherapy. A retrospective analysis was conducted on 96 esophageal cancer patients admitted to our hospital from March 2018 to March 2021 who underwent radical radiotherapy. Among them, 48 patients who received precise radiation therapy to prevent radiation in the lymphatic drainage area were included in the ENI group, and 48 patients who received field irradiation were included in the IFI group. Compare and analyze the total clinical response rate, local control rate within 3 years after treatment, survival rate, and incidence of adverse reactions after radiotherapy between two groups of patients. There was no statistically significant difference in the total clinical response rate between the ENI group and the IFI group after radiotherapy (P > .05). There was no statistically significant difference in local control rate and survival rate between the ENI group and the IFI group within 3 years of treatment (P > .05). The incidence of postoperative complications in the ENI group was significantly higher than that in the IFI group, with a statistically significant difference (P < .05). When giving radical radiotherapy to esophageal cancer patients, the clinical total effective rate, survival rate, and local control rate of involving field irradiation are equivalent to the preventive radiation effect of precise radiotherapy for lymphatic drainage area. Besides, involving field irradiation can reduce the incidence of adverse reactions in patients after radiotherapy, which has high clinical value.
The invention relates to a composite nanoparticle preparation for injection administration for treatment of tumors, in particular to compound palmitoyl ascorbic acid ester and docetaxel composite nanoparticles and a preparation method thereof. Through combination of palmitoyl ascorbic acid ester and docetaxel, it is found through in-vitro and in-vivo experiments that the composite nanoparticles can remarkably enhance the anti-tumor efficacy of docetaxel, and docetaxel can achieve the efficacy at an extremely-low dose. Through intravenous administration, artery administration, intramuscular administration, subcutaneous administration, intraperitoneal administration and other administration modes, especially interventional administration such as intravenous injection and intratumoral injection, the effectiveness and safety of clinical application of docetaxel are improved. The adopted preparation method is simple in process and low in cost. The prepared nanoparticles are uniform in particle size, high in encapsulation rate and good in drug release property. Compared with palmitoyl ascorbic acid ester nanoparticles or docetaxel single-recipe nanoparticles, the effects of inhibiting tumor cell growth in vitro and resisting tumor proliferation in vivo of the compound are enhanced remarkably.
This is a 4-day randomized double-blinded intervention study of 30 treatment seeking adults with alcohol use disorder, who are receiving alcohol detoxification treatment at the Hospital of the University of Pennsylvania, Cedar Detox Center. Within 24 hours of admission to the inpatient unit, participants will be consented and randomized to receive 3x daily of 12g of KS (n=15; 1,3-butanediol and D-hydroxybutyric acid from Kenetik, VitaNav Inc., Washington D.C.) for 4 days or placebo beverage (n=15). Benzodiazepines and other "comfort" medications will be administered daily following the HUP Cedar withdrawal management protocol, with benzodiazepines administered based on withdrawal symptoms, monitored with the revised Clinical Institute Withdrawal Assessment for Alcohol. The revised Clinical Institute Withdrawal Assessment for Alcohol is given three or more times a day clinically to determine patient withdrawal levels and adjust medication dosages. Total daily maximum revised Clinical Institute Withdrawal Assessment for Alcohol scores, benzodiazepine dosage, and other "comfort" medications will be analyzed with a repeated measures design, with a binary factor for intervention, factor of time, and intervention by time interaction. Daily mood questions and alcohol craving questions will assess differences between treatment groups. After 4 days of study intervention, all participants will undergo an approximately 1.5-hr. magnetic resonance imaging session.