anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The surgeons will be divided into 2 arms based on their surgical experience time: less than 5 years (junior surgeons) and more than 5 years (senior surgeons). The learning curve analysis will include 30 procedures for each surgeon group in each centre. For ethical reasons, all the junior surgeons will first assist the senior surgeons in performing vNOTES salpingectomy, as first assistant in at least 15 procedures, before starting to perform them as operators.
The behavior of the variables of functional, clinical and metabolic outcome will be analyzed before the exercise protocol is performed. In this stage the volunteers will first perform the protocol for exhaustion, and in specific moments the blood lactate and clinical data will be collected, and 2h after the beginning of the exercise protocol, the functional tests will be performed.
There is no known antidote for overdoses of lapatinib tablets. The maximum oral doses of lapatinib that have been administered in clinical trials are 1,800 mg once daily. More frequent ingestion of lapatinib tablets could result in serum concentrations exceeding those observed in clinical trials and could result in increased toxicity. Therefore, missed doses should not be replaced and dosing should resume with the next scheduled daily dose.   


Asymptomatic and symptomatic cases of overdose have been reported. The doses ranged from 2,500 to 9,000 mg daily and where reported, the duration varied between 1 and 17 days. Symptoms observed include lapatinib-associated events [see Adverse Reactions (6.1)] and in some cases sore scalp, sinus tachycardia (with otherwise normal ECG), and/or mucosal inflammation.

Because lapatinib is not significantly renally excreted and is highly bound to plasma proteins, hemodialysis would not be expected to be an effective method to enhance the elimination of lapatinib. 

Treatment of overdose with lapatinib tablets should consist of general supportive measures.
Pulmonary fibrosis is a kind of fibrotic interstitial pneumonia with poor prognosis. Aging, environmental pollution, and coronavirus disease 2019 are considered as independent risk factors for pulmonary fibrogenesis. Consequently, the morbidity and mortality striking continues to rise in recent years. However, the clinical therapeutic efficacy is very limited and unsatisfactory. So it is necessary to develop a new effective therapeutic approach for pulmonary fibrosis. Human umbilical cord mesenchymal stem cells (hucMSCs) are considered as a promising treatment for various diseases because of their multiple differentiation and immunomodulatory function. The key bottleneck in the clinical application of hucMSCs therapy is the high-quality and large-scale production. This study used FloTrix miniSpin bioreactor, a three-dimensional (3D) cell culture system, for large-scale expansion of hucMSCs in vitro, and proved 3D cultured hucMSCs inhibited the differentiation of fibroblasts into myofibroblasts and myofibroblasts proliferation and migration, leading to slow down the development of pulmonary fibrosis. Further mechanistic studies clarified that hucMSCs reduced the amount of binding between circELP2 and miR-630, resulting in blocking YAP/TAZ translocation from cytoplasm to nucleus. This condition inhibited mitochondrial fusion and promoted mitochondrial fission, and ultimately improved fusion/fission balance and cellular homeostasis. To sum up, this work clarified the anti-fibrosis and mechanism of hucMSCs cultured from the 3D FloTrix miniSpin bioreactor. We hope to provide new ideas and new methods for the clinical transformation and industrialization of hucMSCs therapy.
Immune-mediated inflammatory diseases (IMIDs) such as psoriasis, hidradenitis suppurative, spondyloarthritis, and inflammatory bowel disease, are associated with increased risk of somatic and psychiatric comorbidities as well as reduced socioeconomic status and a risk of further autoimmune diseases. The unmet needs in the care of patients with IMIDs are caused by a lack of patient-centricity in the usual specialized siloed approach to these diseases. The overall aim of this study is to determine the effectiveness of an interdisciplinary combined clinic intervention compared to usual care in a population of patients with the IMIDs: psoriasis, hidradenitis suppurativa, spondyloarthritis, ulcerative colitis, and Crohn's disease. This trial is designed to determine if the interdisciplinary intervention works in a real-world setting and thus has several pragmatic elements. The hypotheses will be tested in a randomized, usual care controlled, parallel-group clinical trial. Consecutively enrolled subjects are randomly assigned in a 2:1 ratio to either treatment in the interdisciplinary combined clinic or usual care in a hospital clinical setting. 300 subjects (anticipated) will be randomized to either multidisciplinary combined clinic intervention (200 subjects, anticipated) or usual care (100 subjects, anticipated). The study will consist of a 24-Week active intervention period and an additional 24-Weeks follow-up period.
Upon discovering low T3 or low T4 levels, administer oral levothyroxine sodium tablets daily. If accompanied by a decrease in TSH, the regimen is 100μg qd (for individuals weighing \<75kg) or 150μg qd (for individuals weighing \>75kg). If not accompanied by a decrease in TSH, the regimen is 50μg qd. However, if thyroid function does not significantly improve within 3 days of medication, the regimen is adjusted to 100μg qd. Treatment should continue until transfer out of the NICU or discharge, with a minimum duration of 7 days.
In this arm, ECoG data will be reviewed for SDs in real-time using the bedside clinical CNS monitor. As a secondary measure, recognition of SDs will be facilitated by custom software on a laptop that receives data from the CNS monitor. Data on SD occurrence will be used to guide treatment in a tier-based therapeutic escalation and de-escalation protocol with the goal of SD suppression. Therapies to be used among the tiers include adjusted targets for MAP, CPP, PaCO2, plasma glucose, temperature, as well as ketamine pharmacotherapy. Changes between tiers are determined by the success or failure of SD suppression at the given treatment level.
Firearm violence in K-12 schools is a persistent public health threat in the US. The negative impact of these tragedies on children and school staff is significant. School-wide efforts (e.g. metal detectors, active shooter drills, armed school personnel, and two dozen others) to improve safety and assuage fears are being widely implemented in public K-12 schools across the US. Yet, the effectiveness of most of these strategies at deterring school shootings has never been scientifically tested. Moreover, school districts may differentially use these strategies based on factors unrelated to school safety, including as a means to discipline students. These gaps in evidence are particularly significant, as the U.S. K-12 public school system currently serves an estimated 51 million children. The proposed research team has conducted pilot and preliminary research demonstrating the feasibility of the larger study proposed here.

This will be accomplished through a nationally representative, population-based, case-control study comparing hundreds of case schools that have experienced a school shooting and randomly selected control schools that have not experienced such an event using epidemiological incidence density sampling. Case data will be ascertained primarily via the FEMA-funded Naval Postgraduate School K-12 School Shooting database. Additional databases that record and publicly report school shooting incidents will be linked and harmonized. One control school will be randomly selected from a national database of public K-12 schools at the National Center for Education Statistics and matched to each case school based on state, urban/nonurban, and elementary/middle/high school status. Both case and control schools will have a list of school safety tactics and policies that were in place, or not in the case school at the time of shooting and the control schools during same time period.

Publicly accessible school safety plans and multiple publicly available secondary sources of data will be used to determine the safety strategies in place at both case and control schools during the school year before each case school's shooting event. These data will be linked to data on school suspensions and expulsions, obtained from the national Civil Rights Data Collection effort. Results will newly inform school policies and practices to reduce gun violence and promote healthy experiences for children across disparate school communities.
PROBLEM TO BE SOLVED: To provide a melamine production inhibitor which contains as an active ingredient the solvent extract of a specific plant and is used in cosmetics, medicines, quasi drugs, foods and the like, and to provide the use. SOLUTION: This melamine production inhibitor contains as an active ingredient the solvent extract of at least one plant selected from the group consisting of Rauwolfia serpentina(L.) Bth. Ex Kurz (Indonesian name: Pule pandok), Oxalis corniculata Linn. (Indonesian name: Semanggi) and Pipturus argenteus (Forst. f.) (Indonesian name: Trembesi). The melamine production inhibitor is added to cosmetics, medicines, quasi drugs, foods and the like to utilize the excellent melamine production-inhibiting action.
Persistent engagement in maladaptive patterns of thinking is a hallmark of depression. In those who suffer from a chronic course of the disorders, tendencies towards engagement in such patterns of thinking are likely to have become habitual and automatic in nature. Recent research has begun to elucidate potential cognitive and neurophysiological bases of such persistence. There is evidence that depressed patients show significant deficits in performance monitoring (Weinberg, Dieterich, \& Riesel, 2015). Research on error-related negativity (ERN), a signal that occurs briefly after commission of an error, has reported significant aberrations in depressed suggesting deficits at the early stages of processing discrepancies. Deficits in ERN have been suggested to serve as an endophenotype for depression and psychopathology more generally (Manoach \& Agam, 2013). Preliminary findings suggest that deficits remain even when symptoms are reduced following established treatments. Similarly, there is evidence for increased tendencies to elaborate negative information as evidenced by stronger late positive potentials (LPP; Auerbach, Stanton, Proudfit, \& Pizzagalli, 2015) and an increased rigidity of spontaneous activity of the brain during rest as indicated by increased long-range temporal correlations of spontaneous brain oscillations (LRTC; Bornas et al., 2013).

Interventions using mental training may be particularly suited to address these aberrations. Indeed even brief training in mindfulness has been found to have significant neuroplastic effects (Tang et al., 2010) The aim of the current study was therefore to investigate the effects of a brief intervention using training in mindfulness meditation on the above listed parameters. Chronically depressed patients were randomly allocated to receive either a two-week mindfulness training or a resting control training. EEG was measured before and after the intervention along with self-reports of current symptoms and resilience/vulnerability factors. We expected the mindfulness training to have significantly stronger effects on ERN, LPP, and LRTC than the resting control training.
BACKGROUND: Advancements in treatment have resulted in improved survival among people living with HIV. However, additional years of life are not necessarily spent in good health, as frailty tends to develop at a younger age among people living with HIV. We set out to examine the prevalence of frailty and its correlates among older adults living with HIV in Canada, with a primary interest in nadir CD4 count.
METHODS: We performed a cross-sectional analysis of the Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study, a Canadian cohort of people living with HIV aged 65 years or older. Participants were assessed using the Fried Frailty Phenotype at cohort entry, and those meeting ≥3 criteria were characterized as frail. We used Poisson regression with robust standard errors to estimate the association between nadir CD4 count and frailty, as well as age, gender, time since HIV diagnosis, comorbidities, marital status, and loneliness.
RESULTS: Among 439 participants included in this analysis (median age 69 years, interquartile ranges 67-73), prevalence of frailty was 16.6%. Frailty was not associated with nadir CD4 count. Not being in a relationship (aRR 2.09, 95% CI 1.01 to 4.30) and greater degree of loneliness (aRR 1.25 per 10 point increase on UCLA loneliness scale, 95% CI 1.09 to 1.44) were associated with frailty.
CONCLUSIONS: Frailty occurred in 16.6% of older adults living with HIV in this cohort. While nadir CD4 count did not correlate with frailty, being single and lonely did, highlighting the importance of recognizing and addressing these social vulnerabilities among people aging with HIV.
The relevance of diet, sleep, and stress and their metabolic consequences in cardiovascular risk is principal. Current improvements and developments in food labeling and personal self-tracking devices and applications (e.g. continuous glucose monitors \[CGMs\] and food logging apps), signal potential for better quantification of personal traits that could assist in defining personalized approaches for glycemic control. The objective of the proposed study is to evaluate daily glucose fluctuations and blood glucose time-in-range in relation to dietary intake and correlate excursions with metabolic risk factors in non-diabetic adults with one risk factor for diabetes mellitus. With the use of CGM technology to explore daily blood glucose trends in patients at risk for diabetes, the goal is to investigate relationships between blood glucose and metabolic parameters as well as sleep and stress factors.

The study will include two visits. During the first visit, the patient is explained the study details, their consent is obtained, their metabolic parameters measured, perceived stress scale questionnaire administered, and finally, the CGM is placed on them. The patient will be asked to return after one week to return the CGM reader, so the study team may collect the data.
The invention discloses a pill for strengthening tendons and bones and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The pill for strengthening tendons and bones is prepared from radix Angelicae Pubescentis, radix Gentianae Marcrophyllae, radix Saposhnikoviae, radix Clematidis, radix Codonopsis, radix astragali, radix rehmanniae, radix Paeoniae alba, atractylodis rhizoma, carthami flos, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, notoginseng radix, scolopendra, rhizoma Polygoni Cuspidati, rhizoma homalomenae, caulis Spatholobi, rhizoma Atractylodis, radix Dipsaci, radix Sangusorbae, herba Taxilli, ramulus Mori, coicis semen, poria, rhizoma Dioscoreae, eucommiae cortex, cortex Magnolia officinalis, herba Lycopodii, rhizoma Cibotii and Glycyrrhrizae radix. The whole formula takes wind-cold-damp arthralgia as the main ingredient and is supplemented with the liver and kidney tonifying and qi and blood supplementing herbs. The healthy qi is compatible with pathogenic factors, eliminating pathogenic factors without damaging healthy qi, strengthening healthy qi without retaining pathogenic factors. The main cure symptoms are as follows: the function is as follows: invigorating kidney, strengthening bone, promoting blood circulation, removing blood stasis, nourishing blood, strengthening tendons, dispelling pathogenic wind, removing dampness, activating collaterals, and relieving pain; the main indications are: pain in neck, shoulder, waist and leg, osteoarthritis, scapulohumeral periarthritis, sciatica, lumbar disc herniation, hyperosteogeny, etc. Can relieve and eliminate symptoms such as bone joint pain and swelling, and improve joint movement function.
The invention relates to a Chinese medicinal preparation for treating hypertension. The Chinese medicinal preparation is prepared from the following raw material medicaments in part by weight: 12 parts of ear shell, 12 parts of root of red-rooted salvia, 15 parts of tall gastrodia tuber, 15 parts of inula flower, 15 parts of Szechuan lovage rhizome, 15 parts of red peony root, 10 parts of virgate wormwood herb, 10 parts of Indian buead, 10 parts of atraotydin, 10 parts of akebia stem, 10 parts of Chinese angelica and 10 parts of divaricate saposhnikovia root. The formulation of the Chinese medicinal preparation comprises pills, powder, tablets, oral liquid and capsules prepared by the conventional preparation process or a modern preparation process. Due to the combination of the selected medicinal materials, the Chinese medicinal preparation has the effects of quickening blood, dispelling stasis, clearing heat, cooling blood, inducing diuresis for treating strangurtia and expelling pathogenic wind from the body surface. When the Chinese medicinal preparation is taken orally, the immunity function of organisms is improved, and the Chinese medicinal preparation has good treatment effect on hypertension caused by various reasons. Clinical application shows that the Chinese medicinal preparation has the advantages of quick response, obvious treatment effect, high tolerance, low cost and no side or toxic effect.
Patients with known or suspected Dopamine beta-Hydroxylase Deficiency were administered Droxidopa doses of 25 mg, 50 mg, 100 mg, 200 mg, 250 mg or 300 mg up to three times daily. Supine and upright blood pressures were subsequently measured 60 to 240 minutes post-dose.
PROBLEM TO BE SOLVED: To prepare a composition for oral cavity, having preventing effects on dental caries and periodontosis, excellent in flavor at the time of use, capable of manifesting a new flavor by changing the flavor after use and sustaining the flavor for a long period by formulating a specific glycoside therein. SOLUTION: This composition for oral cavity is obtained by formulating a glycoside in which an aglycone part is one or more of eugenol, raspberry ketone, isoeugenol, shogaol, capsaicine and vanillin therein. The glycoside is a compound prepared by bonding saccharides such as monosaccharides, e.g. glucose, galactose, mannose, rhamnose or xylose or disaccharides, e.g. lactose or maltose to the eugenol, raspberry ketone, isoeugenol, shogaol, capsaicine or vanillin through D-glucoside bond. The glycoside is formulated at about 0.005-5.0wt.% as the formulation concentration thereof. The composition is useful as, e.g. a toothpaste, a mouthwash, a troche or a chewing gum.
PURPOSE: Soluble divalent and multivalent heterodimeric analogs of proteins and preparation method thereof are provided which are related to immuno-regulation are useful for studying TCR/MHC interactions, lymphocyte tracking, identifying new antigens. CONSTITUTION: Divalent peptide/MHC complexes or T cell receptors (superdimers) are constructed, to increase the avidity of soluble analogs for their cognates to biologically relevant levels. Using a recombinant DNA strategy, DNA encoding either the MHC class II/peptide or TCR heterodimers are ligated to DNA coding for murine Ig heavy and light chains. These constructs are subsequently expressed in a baculovirus expression system. Enzyme-linked immunosorbant assays (ELISA) specific for the Ig and polymorphic determinants of either the TCR or MHC fraction of the molecule indicates that infected insect cells secreted approximately 1 ug/ml of soluble, conformationally intact chimeric superdimers. SDS-PAGE analysis of purified protein shows that expected molecular weight species. The results of flow cytometry demonstrates that the TCR and class II chimeras bound specifically with high avidity to cells bearing their cognate receptors.
The grid and link search methods are used to recover scattered skeletal remains. Neither have not been compared robustly and clear guidelines for the link method have not been sufficiently developed. The study aimed to compare the effectiveness and efficiency of both methods and propose guidelines for the link method. The scattering patterns of two scavengers of forensic relevance-slender mongooses (Galerella sanguinea) and black-backed jackals (Canis mesomelas)-were recreated using four pig skeletons (Sus scrofa domesticus). Two groups (n = 6 each) were assigned a different method to recover the scattered remains. The length of the search and when each bone was located for each scatter pattern was recorded for each group and scatter pattern. A Likert scale questionnaire assessed participants' perceptions of their assigned method. A paired t-test (p = 0.005) compared the efficiency of each method and the questionnaire answers. Both methods were effective, recovering 100% of all remains. The link method was more efficient for both scatter patterns, despite there being no statistical significance (jackal: p = 0.089; mongoose: p = 0.464). Participants indicated favorable views for both methods; however, the link method scored significantly more favorably (p = 0.01) for efficiency. Specific guidelines were developed for the use of the link method. The link method is suggested for the recovery of scattered remains in forensic contexts, especially when the scavenger, its behavior, and scattering pattern is known or suspected.
There is strong reason to expand the scope of current adherence programs to include consideration of a group of health protective variables known as 'psychosocial assets'. These assets include cognitive factors, such as optimism, emotional factors, such as positive affect, and positive social relationships. Increased psychosocial assets such as positive affect are associated with reduced morbidity and mortality, slower slower HIV progression, and reduced burden of depression symptoms. However, there has been limited translation of positive affect interventions to support patient self-management. In this study, we extend previous research on positive affect and adherence through the APPEAL program. The Affect, Promoting Positive Engagement, and Adherence for Life (APPEAL) program is an intervention that combines positive affect approaches to promote adherence in patients who have suboptimal adherence. We seek to implement the program, assess its feasibility, and describe associations with theoretically derived mechanisms of change, including positive affect.
According to the present invention, a method for manufacturing a fermented oat composition for a companion animal comprises: a first step of roasting oats; a second step of drying and grinding the roasted oats to produce oat powder; a third step of drying and pulverizing pork potatoes to produce pork potato powder; a fourth step of preparing a first mixture by mixing the oat powder, the pork potato powder, and water; a fifth step of preparing a second mixture by mixing fructooligosaccharides, lactic acid bacteria, and yeast with the first mixture; a sixth step of producing a fermented product by fermenting the second mixture; and a seventh step of drying the fermented product. In the sixth step, fermentation is carried out at a temperature of 30℃. In addition, in the fourth step, the first mixture is prepared by mixing 9 wt% of oat powder and 1 wt% of pork potato powder with 100 wt% of water. In addition, in the fifth step, the lactic acid bacteria are one or more of Lactobacillus reuteri, Lactobacillus plantarum, and Lactobacillus sakei. Additionally, in the fifth step, the yeast is Saccharomyces cerevisiae. The present invention can improve digestibility.