anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of antibiotic-induced microbiota depletion (AIMD) on this transition. In 61 patients with AKI, 59 plasma metabolites were assessed to determine the risk of AKI-to-CKD transition. An AKI-to-CKD transition murine model was established four weeks after unilateral ischemia-reperfusion injury (IRI) to determine the effects of AIMD on the gut microbiome, metabolites, and pathological responses related to CKD transition. Human proximal tubular epithelial cells were challenged with CKD transition-related metabolites, and inhibitory effects of NADPH oxidase 2 (NOX2) signals were tested. Based on clinical metabolomics, plasma trimethylamine N-oxide (TMAO) was associated with a significantly increased risk for AKI-to-CKD transition [adjusted odds ratio 4.389 (95% confidence interval 1.106-17.416)]. In vivo, AIMD inhibited a unilateral IRI-induced increase in TMAO, along with a decrease in apoptosis, inflammation, and fibrosis. The expression of NOX2 and oxidative stress decreased after AIMD. In vitro, TMAO induced fibrosis with NOX2 activation and oxidative stress. NOX2 inhibition successfully attenuated apoptosis, inflammation, and fibrosis with suppression of G2/M arrest. NOX2 inhibition (in vivo) showed improvement in pathological changes with a decrease in oxidative stress without changes in TMAO levels. Thus, TMAO is a key metabolite associated with the AKI-to-CKD transition, and NOX2 activation was identified as a key regulator of TMAO-related AKI-to-CKD transition both in vivo and in vitro.
Compounds may have at least two structural units, which may be referred to as ligands. Each structural unit includes at least one spacer group and two or more donor groups. Compounds may have two or more iron(III) cations, one or more of which may be a high-spin iron(III) cation or high-spin iron(III) cations, two or more gallium(III) cations, or at least one iron(III) cation, one or more of which may be a high-spin iron(III) cation or high-spin iron(III) cations, and at least one gallium(III) cation, where the iron(III) cation(s) and/or the gallium(III) cation(s) coordinate to the donor groups. The compounds may be self-assembled cages. A composition may include one or more of the compound(s) and a pharmaceutically accepted carrier. Methods of imaging use one or more of the compound(s) and/or one or more of the composition(s).
The invention relates to a method for synthesizing a traditional Chinese medicine for treating diabetes. The method comprises the following steps: decocting raw radix astragali and Chinese yam with water to prepare a first decoction; grinding rhizoma polygonati and herba cistanche to prepare pills; decocting radix rehmanniae and radix astragali with water to prepare a first decoction; administrating the pills by first decoction or the second decoction. The first decoction has the functions of supplementing Qi and nourishing Yin, and activating blood dredging collaterals, and is mainly used for treating qi and yin deficiency as well as blood stasis. The second decoction has the functions of nourishing kidney and solidifying health, tonifying the liver and kidney, promoting blood circulation and removing meridian obstruction, can be administrated by being decocted with water, and can be used for treating kidney deficiency. The pills have efficacy for benefiting qi and nourishing yin. Compared with the traditional west medicine for treatment, the employed traditional Chinese medicines have little side effect. Compared with Chinese traditional treatment, three formulas can be respectively administrated, so that the treatment can be comprehensive.
Provided is a tablet coater machine with adjustable stirring sheet system, which is configured with a machine that drives a rotating cylinder for rotation by a power mechanism, wherein one end of the rotating cylinder is closed and the other end is an opening for material feeding and discharging. The interior of the rotating cylinder is configured with a spraying system, which is communicated with an air supply device. When the rotating cylinder is continuously rotated, the tablets inside the rotating cylinder may be continuously rotated and turned and be simultaneously coated. The present invention is characterized in that: the rotating cylinder is at least configured with a pair of stirring sheet systems. The stirring sheet system comprises a base, a lining tube and an adjusting rod that are penetrated through each other, wherein the stem of the adjusting rod is penetrated through the lining tube and extended into the interior of the rotating cylinder for connecting with the stirring sheets. The stirring sheets may be directly adjusted by turning the adjusting rod to obtain the best stirring angle and facilitate the coating operation. The cleaning of rotating cylinder may be easier and safer. The present invention is very suitable for performing the coating operation for tablets of different quantities or sizes for multiple times.
Draw blood from the infected individual. The blood should contain part of/the whole genome of the virus in question. Modulated PCR techniques would allow for the differentiation of the genetic material from the rest of the container of blood. Regular PCR should be done to create copies of the genome /parts of the genome of the virus in question. This should produce a therapeutic and a potential vaccine. With different strains of the virus the persons own infected blood can be used. Information left out due to my policy.
315,009. Basch, E. March 8, 1928. Asorbent and filter paper. - Paper, particularly filter paper, is impregnated with a hot solution of borax which is allowed to crystallize at above 62‹ C. In this way the paper contains pentahydrate of borax i.e. borax with five molecules of water. The impregnated paper is moistened and used for heat treatment of hair in a hair-waving machine.
Caffeine, the most widely used psychoactive drug in the world, exerts its behavioral effects by antagonizing adenosine receptors (AR). Four different human AR subtypes have been found and there is evidence that the stimulatory effect of caffeine is mainly caused by an inhibition of transmission via adenosine A(2a) receptors. A significant association has been found in healthy infrequent caffeine users between caffeine-induced anxiety and two linked polymorphisms on the A(2a) receptor gene, the 1976C greater than T and 2592C greater than Tins polymorphisms. In one study looking at monozygotic and dizygotic twin pairs, there was much evidence that individual differences in caffeine use, intoxication, tolerance, and withdrawal were substantially influenced by genetic factors. Family and twin studies have shown that genetic factors may increase vulnerability to panic disorder. In one study a systematic mutation screening and association study of the A(1) and A(2a) adenosine receptor genes in panic disorder showed a significant association between the 1976T allele and 1976T/T genotype of the A(2a) receptor gene and panic disorder. As the 1976T/T genotype of the A(2a) receptor gene has been associated with both increased caffeine-induced anxiety in healthy controls, and has been associated with increased vulnerability to panic disorder, we wish to study whether the 1976T/T genotype in panic disorder patients is associated with increased caffeine-induced anxiety.

This study will study subjects with panic disorder and healthy controls. Based on previous studies the following hypotheses will be tested (2 replication and 2 new hypotheses): Replication; (1) panic disorder subjects will report higher anxiety after a caffeine challenge than the healthy control subjects. (2) healthy controls with the1976 T/T polymorphism will report increased anxiety after a caffeine challenge compared to healthy controls with the 1976 C/T and 1976 C/C genotypes, New hypotheses; (3) panic patients (two separate groups: currently ill and remitted) with the 1976 T/T polymorphism will report increased anxiety after a caffeine challenge compared to panic patients with the 1976 C/T and 1976 C/C genotypes, (4) panic patients (two separate groups: currently ill and remitted) with the 1976 T/T polymorphism will report increased anxiety after a caffeine challenge compared to healthy controls with the 1976 T/T polymorphism will report increased anxiety after a caffeine challenge compared to healthy controls with the 1976 T/T genotype.
Sudden cardiac arrest (SCA) is the leading cause of sudden death in athletes during high-level, organised sport. Patient-related and event-related factors provide an opportunity for rapid intervention and the potential for high survival rates. The aim of this consensus was to develop a best-practice guideline for dedicated field-of-play medical teams responding to SCA during an organised sporting event. A task-and-finish group from Resuscitation Council UK identified a stakeholder group of relevant experts and cardiac arrest survivors in March and April 2022. Together, they developed a best-practice guideline using the best available evidence. A public consultation period further refined the guideline before it was finalised in December 2023. Any sudden collapse, without rapid recovery during sporting activity, should be considered an SCA until proven otherwise. Field-of-play medical teams should be empowered to access the collapsed athlete as soon as possible and perform initial essential interventions in situ. This includes a suggested minimum of three cycles of cardiopulmonary resuscitation and defibrillation in persistent shockable rhythms while other aspects of advanced life support are initiated. There should be careful organisation and practice of the medical response, including plans to transport athletes to dedicated facilities for definitive medical care. This best-practice guideline complements, rather than supersedes, existing resuscitation guidelines. It provides a clear approach to how to best treat an athlete with SCA and how to organise the medical response so treatments are delivered effectively and optimise outcomes.
<P>PROBLEM TO BE SOLVED: To provide a new technology and a method for computerizing medical treatments and improving medical tool repertory and to provide a business method, using such a technology and a method.  <P>SOLUTION: The business method to be used for classifying patient samples is provided. The method includes a stage for collecting case samples which exhibit a clinical phenotype condition and control samples which do not exhibit phenotype conditions. A system preferably uses a mass spectrometric platform system for identifying the patterns of polypeptides in the case samples and the control samples, regardless of at least some specific identifications of the polypeptides. This system runs optimum assay, capable of acquiring high sensitivity, specificity, and/or cost effectiveness on the basis of representative patterns of identified conditions. The business method provides the marketing of diagnostic products, using the representative patterns.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
SL-701 emulsion and the adjuvant poly-ICLC will be administered twice weekly for the initial 2 weeks, every 7 days during the subsequent 3 doses, and subsequently every 14 days for the subsequent 9 doses (16 doses total) through Week 22, and every 4 weeks thereafter. Bevacizumab will be administered every 2 weeks, subsequent to the administration of SL-701/poly-ICLC.
The invention provides a human interleukin-6 receptor (hIL6R) monoclonal antibody with high affinity. The antibody can perform a specific recognition on a restructured hIL6R protein so as to effectively block the combination of the restructured hIL6R and the restructured IL6. A double-resistant sandwich enzyme-linked immune detection method established on the basis of the antibody can be used for the specific detection of the IL6R. The antibody can perform the specific recognition of the hIL6R on a cell membrane so as to effectively block the combination of the hIL6R and the IL6 on a cell, thereby preventing cell proliferation from being induced, i.e. the cell proliferation inhibition effect is realized. As a result, the antibody provided by the invention can be used as a candidate antibody for further development of clinical therapeutic medicines.
The observation is unequivocal: nearly half of cancer deaths could be avoided ! This statement, both alarming and hopeful, underscores the crucial importance of preventive measures in the fight against the scourge that is cancer. Indeed, if nearly half of cancer deaths are preventable, it means that it is possible to act on certain modifiable risk factors. Smoking and alcohol consumption are among the most influential behaviours in the risk of death from cancer. Similarly, overweight and obesity, considered a true pandemic, contribute significantly to the increase in the number of cancer cases over the past decade. Environmental and occupational exposure to various physical, chemical, and biological carcinogens constitutes another set of largely avoidable factors. Now, more than ever, it is imperative to intensify efforts in implementing effective prevention strategies to counter the growing burden of this disease.
A 20 gauge 30 millimeter peripheral intravenous catheter will be placed in an upper extremity vein in standard antegrade fashion (with the tip pointed towards the direction of blood flow). Blood draws from this IV catheter will be attempted twice throughout the study. An infusion of 0.9% normal saline will be connected to the catheter and infused at a rate of 20 milliliters per hour to keep open (TKO) for future use by preventing blood clot development within the catheter.
Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of major genetic variants in the etiology of CP, we conducted exome sequencing on a large-scale cohort with clinical manifestations of CP. The study cohort comprised 505 girls and 1,073 boys. Utilizing the current gold standard in genetic diagnostics, 387 of these 1,578 children (24.5%) received genetic diagnoses. We identified 412 pathogenic and likely pathogenic (P/LP) variants across 219 genes associated with neurodevelopmental disorders, and 59 P/LP copy number variants. The genetic diagnostic rate of children with CP labeled at birth with perinatal asphyxia was higher than the rate in children without asphyxia (P = 0.0033). Also, 33 children with CP manifestations (8.5%, 33 of 387) had findings that were clinically actionable. These results highlight the need for early genetic testing in children with CP, especially those with risk factors like perinatal asphyxia, to enable evidence-based medical decision-making.
BACKGROUND: Atrial fibrillation (AF) increases risk of embolic stroke, and in postoperative patients, increases cost of care. Consequently, ECG screening for AF in high-risk patients is important but labor-intensive. Artificial intelligence (AI) may reduce AF detection workload, but AI development presents challenges.
METHODS AND RESULTS: We used a novel approach to AI development for AF detection using both surface ECG recordings and atrial epicardial electrograms obtained in postoperative cardiac patients. Atrial electrograms were used only to facilitate establishing true AF for AI development; this permitted the establishment of an AI-based tool for subsequent AF detection using ECG records alone. A total of 5 million 30-second epochs from 329 patients were annotated as AF or non-AF by expert ECG readers for AI training and validation, while 5 million 30-second epochs from 330 different patients were used for AI testing. AI performance was assessed at the epoch level as well as AF burden at the patient level. AI achieved an area under the receiver operating characteristic curve of 0.932 on validation and 0.953 on testing. At the epoch level, testing results showed means of AF detection sensitivity, specificity, negative predictive value, positive predictive value, and F1 (harmonic mean of positive predictive value and sensitivity) as 0.970, 0.814, 0.976, 0.776, and 0.862, respectively, while the intraclass correlation coefficient for AF burden detection was 0.952. At the patient level, AF burden sensitivity and positive predictivity were 96.2% and 94.5%, respectively.
CONCLUSIONS: Use of both atrial electrograms and surface ECG permitted development of a robust AI-based approach to postoperative AF recognition and AF burden assessment. This novel tool may enhance detection and management of AF, particularly in patients following operative cardiac surgery.
Within one week after laparoscopic exploration, chemotherapy was started. The curative effect was evaluated every 2-4 cycles. If the operation standard of R0 was met, the second laparoscopic staging was performed: if the peritoneal metastasis reached P 0 or P1a, the operator judged that R0 could be removed. Open radical gastrectomy (D2 / D2 +) was performed. For P1b / c cases, the original treatment was continued until the disease progressed.
Extracellular histones are crucial damage-associated molecular patterns involved in the development and progression of multiple critical and inflammatory diseases, such as sepsis, pancreatitis, trauma, acute liver failure, acute respiratory distress syndrome, vasculitis and arthritis. During the past decade, the physiopathologic mechanisms of histone-mediated hyperinflammation, endothelial dysfunction, coagulation activation, neuroimmune injury and organ dysfunction in diseases have been systematically elucidated. Emerging preclinical evidence further shows that anti-histone strategies with either their neutralizers (heparin, heparinoids, nature plasma proteins, small anion molecules and nanomedicines, etc.) or extracorporeal blood purification techniques can significantly alleviate histone-induced deleterious effects, and thus improve the outcomes of histone-related critical and inflammatory animal models. However, a systemic evaluation of the efficacy and safety of these histone-targeting therapeutic strategies is currently lacking. In this review, we first update our latest understanding of the underlying molecular mechanisms of histone-induced hyperinflammation, endothelial dysfunction, coagulopathy, and organ dysfunction. Then, we summarize the latest advances in histone-targeting therapy strategies with heparin, anti-histone antibodies, histone-binding proteins or molecules, and histone-affinity hemoadsorption in pre-clinical studies. Finally, challenges and future perspectives for improving the clinical translation of histone-targeting therapeutic strategies are also discussed to promote better management of patients with histone-related diseases.
Up to 10 VLBW infants enrolled from the Le Bonheur Children's Hospital NICU. Weekly stool samples will be obtained. After 36 weeks infants diagnosed with BPD per NIH guidelines willl be matched with infants without BPD. Stool samples from these infants will be sent for 16s rRNA sequencing after conclusion of initial enrollment period.
The invention belongs to the diabetes traditional Chinese medicine physical therapy field, and concretely provides a traditional Chinese medicine composition conditioning diabetes. The traditional Chinese medicine composition comprises the following raw materials, by weight, 22-30 parts of radix astragali, 5-10 parts of gen-seng, 6-10 parts of schisandra chinensis, 6-10 parts of dark plums, 10-15 parts of polygonatum rhizome, 10-15 parts of mulberries, 10-15 parts of cassia seeds, 8-12 parts of radix puerariae and 8-12 parts of rhizoma anemarrhenae. The invention also comprises a preparation method for the above traditional Chinese medicine composition. The preparation method mainly comprises steps of extraction, concentration, liquid blending, filling, disinfection and the like. The beneficial effects are that the provided traditional Chinese medicine composition can condition diabetes effectively, thus patients can enter a honeymoon period rapidly, the honeymoon period can be prolonged effectively, and the recurrence rate is lowered. The provided preparation method is advantaged by concise steps and easy popularization, effective components of the raw materials can be extracted effectively furthest, and the traditional Chinese medicine composition with accurate effective component contents is obtained.
Treatment 1 Period: Matching placebo device to the LiRIS inserted into the bladder by cystoscopy on Day 0 and then removed and LiRIS® (continuous release of lidocaine) 400 mg inserted into the bladder by cystoscopy on Day 14 then removed on Day 28. Treatment 2 Period: optional LiRIS® 400 mg inserted into the bladder by cystoscopy on Day 0 then removed on Day 14.
Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 �m which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions are also contemplated.   (Figure 1A)
OBJECTIVES: To report the association of zinc finger and SCAN domain containing 1 antibodies (ZSCAN1-abs) with rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome in patients without tumor.
METHODS: Patients with symptoms compatible with ROHHAD syndrome but without an associated tumor were selected from our database. Serum and CSF samples were examined for the presence of ZSCAN1-abs by an in-house cell-based assay. In addition, samples from 149 patients with several inflammatory and noninflammatory disorders and 50 healthy participants served as controls.
RESULTS: Thirteen patients with ROHHAD syndrome were identified. Of these, we had paired serum/CSF samples from 6 patients and only serum from the other 7. Five of 6 patients (83.3%) with paired serum/CSF (4 children, 1 adult) had ZSCAN-abs only in CSF and 1 had antibodies in serum and CSF. ZSCAN1-abs were not detected in the remaining 7 patients with ROHHAD with only serum available or in any of the 199 control samples.
DISCUSSION: Patients with ROHHAD syndrome should be investigated for the presence of ZSCAN1-abs in CSF. The antibodies do not necessarily predict the presence of a tumor. The detection of ZSCAN1-abs in an adult patient suggests that this condition also occurs beyond the pediatric age.
Background: Buprenorphine initiation in opioid-tolerant patients usually requires decreasing the total opioid intake per day due to its potential for precipitating withdrawal. However, this strategy may not be tolerated in patients who require higher amounts of opioids, such as those with cancer pain. Case Presentation: We utilized a buprenorphine microdosing strategy for a postoperative cancer patient who was previously taking buprenorphine-naloxone for chronic noncancer pain, then initiated on methadone for uncontrolled cancer-related pain. He had a planned cancer resection in the hospital. He subsequently underwent a successful transition from methadone to buprenorphine-naloxone through microdosing in one week with close monitoring in the inpatient setting. Conclusions: Using a microdosing strategy to transition from methadone to buprenorphine-naloxone in a span of days was achieved in this case report. More research regarding the feasibility and tolerability of microinductions is needed, especially in the setting of chronic pain or cancer-related pain.