anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention comprises a glycosidal chalcone forming yellow crystals of melting point 139 DEG C., having the formula C27H32O13, giving an R.F. number of 0.4 on chromatographic analysis with "Whatman" (Registered Trade Mark) No. 1 paper and 15% acetic acid as solvent, and giving a brown spot to U.V. light, a yellow colouration with alcoholic potassium hydroxide and a positive reaction to citroboric acid.  The glycosidal chalcone is obtained by extracting the root of Glycyrrhiza, particularly Glycyrrhiza glabra L. with an anhydrous straight or branched chain aliphatic alcohol of not more than 8 carbon atoms e.g. isobutyl alcohol (suitably after de-fatting by extraction with carbon tetrachloride, ether, benzine, benzene, chloroform or hexane), recovering the chalcone by concentrating the alcoholic extract under reduced pressure and, if desired, purifying by washing with a solvent in which the chalcone is insoluble, such as ether or petroleum ether, and re-extracting and recrystallising with a C1-8 aliphatic alcohol.  The compound is used pharmaceutically (see Group VI).  Specification 901,085 is referred to.ALSO:Pharmaceutical compositions, having anti-spasmodic activity, contain as the active ingredient a glycosidal chalcone forming yellow crystals melting at 139 DEG  C., of the formula C27H32O13, having an RF number of 0.4 on chromatographic analysis with a 15% acetic acid solvent, using "Whatman" (Registered Trade Mark) No. 1 paper, giving a brown spot under U.V. light, a yellow coloration with alcoholic potassium hydroxide and a positive reaction to citroboric acid (see Group IV (b)).  The preparations are used in the treatment of gastrointestinal diseases characterized by muscle spasm, and as detoxicants in the use of antibiotics and antirheumatic compounds such as cortisone, phenylbutazone and aspirin.  The preparations may be administered by oral, rectal or parenteral routes, for example, as tablets, capsules, suppositories and injectable solutions, which may contain conventional excipients.  In addition, the glycosidal chalcone may be admixed with the diglycoside flavanone described in Specification 901,085.
The effect of neutrophil extracellular traps (NETs) on promoting intravascular microthrombi formation and exacerbating the severity of sepsis in patients has gained extensive attention. However, in sepsis, the mechanisms and key signaling molecules mediating NET formation during direct interactions of endothelial cells and neutrophils still need further explored. Herein, we utilized lipoteichoic acid (LTA), a component shared by Gram-positive bacteria, to induce NET extrusion from neutrophils firmly adhered to the glass slides coated with intercellular adhesion molecule-1(ICAM-1). We also used Sytox green to label NET-DNA and Flou-4 AM as the intracellular Ca 2+ signaling indicator to observe the NET formation and fluctuation of Ca 2+ signaling. Our results illustrated that LTA was able to induce NET release from neutrophils firmly attached to ICAM-1-coated glass slides, and the process was time-dependent. In addition, our study indicated that LTA-induced NET release by neutrophils stably adhered to ICAM-1 depended on Ca 2+ signaling but not intracellular reactive oxygen species (ROS). This study reveals NET formation mediated by direct interactions between endothelial ICAM-1 and neutrophils under LTA stimulation and key signaling molecules involved, providing the theoretical basis for medicine development and clinical treatment for related diseases.
Breast cancer (BC) is the most prevalent cancer among women around the world. Finding new and efficient drugs has become a crucial aspect of BC treatment. Liensinine diperchlorate (LIN) and artemisitene (ATT) are natural compounds with potential anti-cancer activities extracted from lotus (Nelumbo nucifera Gaertn) seeds and Artemisia annua, respectively. However, the synergistic anti-breast cancer effectiveness and mechanism of LIN and ATT remain unknown. This study intended to reveal the biological functions and underlying mechanism of combined LIN and ATT treatment in BC. Herein, we first reported that LIN and ATT synergistically mitigated the proliferation, migration as well as invasion of BC cells. Besides, LIN boosted the stimulatory effect of ATT on reactive oxygen species (ROS)-mediated apoptosis in BC cells. Interestingly, LIN and ATT synergistically attenuated the growth of BC patient-derived organoids. Moreover, LIN augmented the inhibitory efficacy of ATT on BC growth in vivo without obvious side effects. Furthermore, the inactivation of PI3K-AKT pathway and its regulated proteins contributed to the therapeutic role of LIN and ATT treatment in BC. Intriguingly, a prediction model constructed as per RNA sequencing data indicated that the combination of LIN and ATT treatment might ameliorate the prognosis of BC patients. In conclusion, our present investigation demonstrated that LIN and ATT synergistically inhibited BC cell proliferation, migration as well as invasion and enhanced ROS-mediated apoptosis via suppressing the PI3K-AKT signaling, and suggested that combining LIN and ATT treatment might be a promising choice for BC therapy.
The study aims to develop and validate a predictive model for effectively predicting in-hospital mortality in patients admitted to the intensive care unit due to Gastrointestinal bleeding (GIB). A retrospective cohort study was conducted, including data from patients in the Electronic Intensive Care Unit Collaborative Research Database (eICU-CRD) and Medical Information Mart for Intensive Care-IV Database (MIMIC-IV) with a diagnosis of GIB. Patients from the eICU-CRD were randomly allocated into both development and validation sets, and those from MIMIC-IV were assigned as an external validation group. Multivariate logistic regression was employed to create a predictive model, which was depicted as a nomogram. This study included a total of 2929 patients with GIB from the eICU-CRD and 718 patients from the MIMIC-IV. To access the dynamic nomogram, please use the following link: https://kangzou.shinyapps.io/DynNomapp_GIB/ . The area under the receiver operating characteristic curve for the nomogram was 0.893 in the development set, 0.860 in the internal validation set, and 0.781 in the external validation set. The mortality rate was 25.7% in the high-risk group (nomogram scores > 101.974) and 2.8% in the low-risk group (nomogram scores ≤ 101.974). The nomogram exhibited excellent discrimination, calibration, and clinical utility in predicting in-hospital mortality among patients admitted to the intensive care unit with GIB.
This observational study is investigating a simple test of usual walking speed, measured using the 4 metre gait speed (4MGS) test in patients with a lung disease called Idiopathic Pulmonary Fibrosis (IPF). Drug development for this disease is slow in part because there is a lack of reliable measurements that can assess effectiveness of treatment. Slow walking speed has been shown to relate to poor outcomes in older adults and people with another lung disease called Chronic Obstructive Pulmonary Disease (COPD). The investigators are interested to see whether usual walking speed in IPF patients changes following a treatment called pulmonary rehabilitation (an exercise and education programme for patients with lung disease) and if it changes, what is the smallest change that is meaningful to patients (the minimum important difference - MID). The investigators are also investigating whether the change in walking speed can predict survival, number of hospital admissions and lung disease progression. This will help inform us of the potential use of 4MGS as an outcome measure. To do this, participants who consent to taking part in the study will be timed walking at their usual walking speed over a distance of 4 metres (13.12 feet) before and after a course of pulmonary rehabilitation and follow-up 1 year after completing pulmonary rehabilitation.
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (Gsdmd-/-) significantly attenuates influenza virus-induced weight loss, lung dysfunction, lung histopathology, and mortality compared with wild type (WT) mice, despite similar viral loads. Infected Gsdmd-/- mice exhibit decreased inflammatory gene signatures shown by lung transcriptomics. Among these, diminished neutrophil gene activation signatures are corroborated by decreased detection of neutrophil elastase and myeloperoxidase in KO mouse lungs. Indeed, directly infected neutrophils are observed in vivo and infection of neutrophils in vitro induces release of DNA and tissue-damaging enzymes that is largely dependent on GSDMD. Neutrophil depletion in infected WT mice recapitulates the reductions in mortality, lung inflammation, and lung dysfunction observed in Gsdmd-/- animals, while depletion does not have additive protective effects in Gsdmd-/- mice. These findings implicate a function for GSDMD in promoting lung neutrophil responses that amplify influenza virus-induced inflammation and pathogenesis. Targeting the GSDMD/neutrophil axis may provide a therapeutic avenue for treating severe influenza.
These participants will wear a smartwatch (Apple Watch) for 6 months during 12 hours a day. The smartwatch will alarm the participant if an irregular heart rhythm is detected. When a participant receives an irregular heartbeat notification, they can record an ECG with the smartwatch. The ECG will automatically be sent to the Telecure team for evaluation.
In partnership with Dr. William Kaiser and the UCLA Wireless Health Institute, our research groups are developing and validating the diagnostic capabilities of device that conducts AEGIS. A belt (AbStats) fits externally around the abdomen and is embedded with acoustic sensors, similar to "electronic stethoscopes." The investigational software is designed to continuously, safely, and comfortably monitor acoustic signals emanating from the esophagus, stomach, and intestines, and stores the data in a HIPAA compliant hard drive. Through the study of associating these readings with current diagnostics and treatments we anticipate that the AEGIS device will eventually provide clinically interpretable information that is immediately actionable. In this study, the Abstats sensor will track signals in tandem with current techniques and standard of care treatments based on those diagnostics. AEGIS analysis could potentially refine, support, or even replace, existing costly and invasive techniques in the diagnosis of gastroparesis, intestinal psueodo-obstruction, colonic inertia, and disorders related to small intestinal bacterial overgrowth (SIBO).
The invention discloses a Qingpeng nasal preparation for stopping pain and diminishing swelling, which is prepared by taking the prescription of traditional Tibetan medicine of Qingpeng ointment as a basic prescription and changing a formulation, and a preparation method thereof. The Qingpeng nasal preparation is prepared by a method that particle medicinal materials are extracted and partial medicinal materials are subjected to ultra-fine crushing, effectively maintains active ingredients of the medicinal materials, greatly improves the content of crude medicines, and improves bioavailability to make treatment effect better. Auxiliary materials selected have good mouldability, so that the product has good permeability, and is better to absorb and quick in response. The Qingpeng nasal preparation has the advantages of convenience of administration, long duration, low allergy rate, convenience of use, portability, no pollution to clothes and the like. A nasal mucosal medicine delivery system is adopted, is quick in absorption and response, and does not have any stimulation or odor. Pharmacodynamic experiments prove that the Qingpeng powder or granules have obvious effects of stopping pain and diminishing swelling.
Designed physical therapy program in addition to whole-body vibration. Down syndrome children will receive the designed physical therapy program for 1 hour in addition to whole-body vibration with an amplitude of 2 mm, vibration frequency ranged from 25 to 30 Hz and, vibration time ranged from 5 to10 minutes. The duration of treatment will be 3 times/week for 12 weeks.
BACKGROUND/AIM: Femoral neck fracture (FNF) seriously impact the health of the elderly and affect their long-term quality of life of the patients. This study aimed to determine whether combining the preoperative Fried Frailty Phenotype (FFP) with serum fibroblast growth factor receptor 3 (FGFR3) and run-related transcription factor 2 (RUNX2) could better predict the prognosis of elderly patients with FNF 3 months after surgery.
MATERIALS AND METHODS: A total of 150 elderly patients with FNF (60-89 years old) were enrolled and divided into a nonfrailty cohort and a frailty cohort based on preoperative FFP evaluation. The hip recovery of patients 3 months after surgery was evaluated using Harris Hip Score (HHS). Serum FGFR3 and RUNX2 levels were analyzed, and the relationship between HHS and serum FGFR3 and RUNX2 levels was evaluated. The specificity and sensitivity of FFP, serum FGFR3 and RUNX2 were evaluated using ROC curves before surgery. Potential prognostic factors were analyzed using multivariate logistic regression.
RESULTS: Serum FGFR3 and RUNX2 levels were lower and hip recovery was poorer in the frailty cohort than in the nonfrailty cohort (p < 0.001). Within 3 months after surgery, there were 12 deaths (17.6%) in the frailty cohort and 1 in the nonfrailty cohort (1.2%) (p < 0.001). FFP assessment combined with serum FGFR3 and RUNX2 levels had a higher diagnostic significance. Readmission and preoperative frailty phenotype were independent factors affecting the prognosis of patients with FNF. HHS scores greater than 70 and higher levels of serum FGFR3 and RUNX2 cutoff values (7.85 ng/mL and 56.5 ng/mL, respectively) were identified as protective factors for prognosis.
CONCLUSION: Assessing FFP alongside serum FGFR3 and RUNX2 levels may aid in evaluating the prognosis of elderly patients with FNF 3 months after surgery.
All patients in this group received common fundamental management, which was as follows: ①Methylprednisolone, administered by intravenous infusion at a 500mg daily for 3 consecutive days and then gradually tailed off in 30 days with administration of oral prednisolone. ②Dehydration drugs.
The invention provides an azaphilones compound derived from marine fungi, a preparation method thereof and application thereof in preparing vibrio-resisting medicines, wherein the marine fungi is Grifola frondosa (Grifola frondosa) Pleosporales sp.) HBU-135 strain with preservation date of 2018, 10 and 18 months, preservation number of CGMCC No.16379, preservation unit of China general microbiological culture Collection center, and preservation unit address of No. 3 of Xilu No.1 of Beijing Korean district. The structural formula of the compound is selected from formulas 1-4. Culturing Geobacillus by fermentation ( Pleosporales sp.) HBU-135 strain, and separating azaphilones compounds from the fermentation product, and the compounds have strong inhibitory activity to various marine vibrios and can be prepared into an anti-arc microbial agent, thereby having wide application prospect.
A device may receive lifestyle information corresponding to an individual with a medical condition. The device may create a lifestyle timeline, associated with the individual, that includes a plurality of items of lifestyle information, included in the lifestyle information, arranged in a chronological order. The device may generate, based on the lifestyle timeline, a recommendation or a prediction associated with a metric related to the medical condition. The recommendation may be generated based on one or more of the plurality of items of lifestyle information. The prediction may be generated using a prediction model that uses one or more of the plurality of items of lifestyle information as input, and generates the prediction using the prediction model. The device may provide information associated with the recommendation or the prediction to identify a dosage associated with treating or managing the medical condition
We will recruit 50 patients 65 years and older scheduled for spine surgery. The design utilizes prospective serial assessments. The enrolled 50 surgical subjects will be evaluated preoperatively and postoperatively over 6 time-points (preoperatively, inta-op, post op day 1, post op day 7, three months and six months) using a widely accepted set of neurocognitive tests, multiple indices of functional recovery, as well as blood tests for plasma biomarkers of inflammation and β-amyloids. Enrollees will be divided in 2 groups: 25 patients with mild cognitive impairment (diagnosed by clinical assessment) and 25 normal elderly patients.

The definition of normal elderly includes: 1). Global Deterioration Scale (GDS) \< 3 and Mini-Mental Exam Score (MMSE) \>27; 2). Performance on neurocognitive testing (including memory) that is within 1.5 Standard Deviation (SD) of the age matched normative data; 3). The informant interview confirming no functional impairment in the subject. The definition of MCI includes: self-reported memory and functional complains, a history of memory decline with functional changes that are corroborated by a knowledgeable informant, and a clinical interview resulting in a GDS=3 or higher and MMSE=26 or lower.
The increasing prevalence of bariatric surgery among women of childbearing age raises critical questions about the correct management of pregnancy following these procedures. This literature review delves into the multifaceted considerations surrounding pregnancy after bariatric surgery, with a particular focus on the importance of preconception counselling, appropriate nutrition assessment, and the necessity of correct folic acid supplementation. Key areas of investigation include nutrient absorption challenges, weight gain during pregnancy, and potential micronutrient deficiencies. Examining the relationship between bariatric surgery and birth defects, particularly heart and musculoskeletal issues, uncovers a twofold increase in risk for women who underwent surgery before pregnancy, with the risk emphasized before folic acid fortification. In contrast, a nationwide study suggests that infants born to mothers with bariatric surgery exhibit a reduced risk of major birth defects, potentially associated with improved glucose metabolism. In addition, this review outlines strategies for managing gestational diabetes and other pregnancy-related complications in individuals with a history of bariatric surgery. By synthesizing existing literature, this paper aims to provide healthcare providers with a comprehensive framework for the correct management of pregnancy in this unique patient population, promoting the health and well-being of both mother and child.
Viral infections can lead to platelet activation and hemostatic complications. However, the extent to which platelet reactivity remains altered after convalescence, contributing to long-term health impairments as observed after COVID-19 is not yet fully understood. Therefore, we conducted a cohort study (DRKS00025217) to determine platelet function in individuals convalesced from mild COVID-19. Assays were performed ex vivo with blood from convalescents at 2-15 weeks and 6-10 months after convalescence, focusing on platelet aggregation, activation markers, and thrombin formation. In addition, two other potentially relevant factors for platelet function were examined: the immunomodulatory mediator sphingosine-1-phosphate (S1P) and the platelet expression of the transporter MRP4 (ABCC4). Our findings indicate that robust platelet functions, including platelet aggregation determined by light transmission aggregometry, and thrombin formation, were not altered in convalescents compared to matched control individuals. However, an elevation in subtle platelet activation markers, such as P-selectin surface expression and activation of glycoprotein IIb/IIIa, was observed 2-15 weeks after convalescence. This was accompanied by an increased expression of MRP4 in platelets and significantly elevated levels of S1P in platelet-poor plasma. Our findings suggest increased platelet sensitization and a pro-inflammatory state even after convalescence from mild COVID-19, pointing toward MRP4 and S1P as associated factors.
BACKGROUND: The ratio between non-high-density lipoprotein cholesterol and high-density lipoprotein cholesterol (NHHR) is a reliable marker for assessing the risk linked to lipid metabolism disorders. Sarcopenia, characterized by age-related loss of muscle mass and strength/function, includes the assessment of muscle mass, muscle strength, and muscle-specific strength. However, research into NHHR's relationship with low muscle mass risk remains unexplored.
METHODS: Our study utilized a cross-sectional approach, examining data derived from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Through multivariable linear and logistic regression, we investigated the relationships of the NHHR with muscle mass and low muscle mass. We visualized the results using smoothing curves and assessed threshold effects. We also performed various subgroup and sensitivity analyses.
RESULTS: This research encompassed 9,012 participants and demonstrated significant nonlinear associations between NHHR and ALMBMI or low muscle mass risk in a generalized additive model (GAM), pinpointing critical NHHR values (3.328 and 3.367) where changes in NHHR significantly impacted ALMBMI and low muscle mass risk.
CONCLUSIONS: The NHHR demonstrates a significant association with an increased risk of low muscle mass among middle-aged Americans. This ratio has potential as a predictive marker for low muscle mass. Further exploration of NHHR is expected to aid in advancing preventive and therapeutic measures for this condition.
This invention comprises a set of dental products and methods to prevent and treat dentinal hypersensitivity, prevent tooth decay, and heal incipient caries by means of Mouth Friendly® dental products containing calcium carbonate, having a preferred particle size of 1 to 100 nanometers (nm), and a preferred weight range of 5 to 30%. Said products must contain 8 to 95 weight percent of xylitol, plus the surfactant system described in U.S. Pat. No. 5,496,541 (Mar. 5, 1996) and U.S. Pat. No. 5,900,230 (May 4, 1999). It is further required that all irritants and other mouth unfriendly ingredients be absent from the dental products of this invention. Additional features of this invention include prevention and treatment of aphthous ulcers, oral mucositis, periodontal disease, perioral dermatitis, halitosis, oral candida, chapped lips, and oral plaque and tartar. This invention also ameliorates the condition of those who suffer from xerostomia and cold sores.
PROBLEM TO BE SOLVED: To obtain a dentifrice composition not generating heat when not providing shear thereto, but generating the heat when providing the shear thereto and providing a warm feeling to gums by including particles of an anhydrous synthetic zeolite covered with a hydrophobic material. SOLUTION: This dentifrice composition having >=1 wt.%, preferably >=3 wt.% water content contains particles of (A) an anhydrous synthetic zeolite covered with (B) a hydrophobic material. preferably in the amount of 5-95 pts.wt., more preferably 10-80 pts.wt. based on 1 pt.wt. component (A). The anhydride of the synthetic zeolite having the formula xM2/n O.Al2 O3 .SiO2 .zH2 O [(x), (y) and (z) are each an arbitrary number; M is an alkali (ne earth) metal; (n) is the valence of the M] is cited as the component A. Waxes, paraffins, shellac, a fatty acid (glyceride) and the like are cited as the component B, and a paraffin wax among them is especially preferable.