anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses a drug composition for curing pain, which uses perilla stem, sappanwood, nutgrass galingale rhizome, immature orange fruit, aucklandia root, white peony root, prism tuber, zedoary, peach seed, safflower, curcuma root, hiraute shiny bugleweed herb, prepared common monkshood mother root, prepared kusnezoff monkshood root, long pepper, cassia twig, angelica, combined spicebush root, hemlock parsley, toad skin, coptis, scutellaria root, borneol, shinyleaf pricklyash root, curare, centipede, beautiful sweetgum fruit, celandine, oldenlandia, etc. as raw materials. The present invention is formed by preparing effective components by aqueous extraction and concentrated ethanol extraction according to the characteristics of each traditional Chinese medicine. Clinical tests prove that the present invention has significant curative effects for treating cancer pain, nerve pain, herpes zoster pain, neck pain, chest-back pain, waist and hip and limb pain, visceralgia and dysmenorrhoea. The speed for alleviating pain is fast, and the duration time of pain alleviating effect is long. The present invention is a pure Chinese herb preparation, and has the advantages of no toxic side effect, no dependency, safety and reliability.
Acute rejection after kidney transplantation can lead to graft loss by irreversible acute rejection or to interstitial fibrosis/ tubular atrophy that can induce graft loss. Induction therapy by either T-cell depleting polyclonal antibodies such as Anti-Thymocyte Globulins (ATG) or non-depleting anti-interleukine 2 receptor monoclonal antibodies (anti-CD25 moAb: basiliximab or daclizumab) are used to prevent acute rejection, especially in highly sensitized patients. Both induction therapy regimens have a different tolerance profile. Infections and haematological side-effects are more frequently reported in patients receiving ATG. With respect to the efficacy, no comparison exists between both induction therapy regimens in high risk immunological patients as actually defined. Within the last few years, the development of new immunological screening tools, i.e. Luminex assay, had lead to a better evaluation of the immunological status of candidates for kidney transplantation, mainly those who were considered as highly sensitized. The aim of our pilot study is to evaluate ATG and basiliximab induction therapy in de novo sensitized kidney-transplant patients (incompatible grafts rate ≥ 50%) without Donor Specific Antibodies (DSAs) detected by Luminex. Maintenance immunosuppressive regimen will be based on the combination of tacrolimus, mycophenolate sodium and steroids. The primary endpoint is a composite of biopsy-proven acute rejection, graft loss, loss of follow up, or death at 6 months post-transplant. The secondary endpoints are the efficacy of the therapy at month 12 posttransplant, and safety parameters (CMV infection, BK virus nephropathy, haematological tolerance, Adverse Events (AE)and Serious Adverse Events (SAE)). Our hypothesis is that basiliximab induction therapy may be sufficiently effective to prevent acute rejection in sensitized patients without DSA. This may reduce the post-transplant immunosuppression-induced side-effects.
Medicaments are prepd. from yeasts or their insoluble extracts of the following families: ascosporogenes, sporobolomycetaceae or cryptococcaceae, apart from those of the genus Saccharomyces, Pichia or Hansenula. The medicaments may consist of whole cells or only their insoluble glucans (branched polymers of glucoses, linked by a majority of beta linkages). The yeasts are all known, and are obtainable from standard culture collections. They are cultured by known methods and may be dried at 50 deg.C or lyophilised. The glucans are isolated by treating the cellular mass with alkali to eliminate proteins, lipids and mannanes, then treating the residue with acid to eliminate glycogen and soluble glucans. The products have no toxic properties orally in mice. The oral daily dosage is 20-500 mg.; if given by injection the dosage is 5-100mg/day. They may also be given topically. Non-specific immunostimulants, useful as antitumour, antiviral and antibacterial agents.
The AI and health counseling group scanned their own mouths at home once a week for 6 months, with each scan taking approximately 5 min. After scanning, they uploaded the results to the AI system for evaluation. The EG-B received both AI-assisted DM and real-person oral health counseling and advice from a counselor, who assessed their oral hygiene conditions on the basis of their scanning results and then provided individualized counseling, such as pointing out unclean teeth and offering suggestions on cleaning tools.
The present invention relates to the field of pharmaceutical preparations, in particular to a 13C methacetin granule, and a preparation method therefor and the use thereof. Provided is the 13C methacetin granule, comprising 13C methacetin, mannitol, a co-solvent and a wetting agent. The 13C methacetin granule has good stability, is beneficial for storage and the production of subsequent preparations, etc. The 13C methacetin granule has good water solubility, can be rapidly dissolved in water during clinical use, and is convenient to take. Further provided is the use of the 13C methacetin granule in the preparation of drugs, reagents or kits for disease diagnosis, evaluation of the liver reserve function and preoperative and postoperative evaluation of the liver. The provided preparation method of the 13C methacetin granule has mild conditions, simple operation and convenient production control.
A system for confirming acquisition of a fluid sample is provided. The system includes a wearable electronic device configured to be worn by a user. The device has a housing, at least one imaging sensor associated with the housing, a data transmission interface for sending data to or receiving data from an external electronic device, a microprocessor for managing the at least one imaging sensor and the data transmission interface, and a program for acquiring and processing images acquired by the at least one imaging sensor. The system further includes a sampling device for collecting a fluid sample in a sample container and at least one identification tag attached to or integrally formed with the sampling device or sample container. The at least one identification tag includes or is associated with a tracking code. C-1 I!4 - -- - - - - - - -
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), a transformation product of tyre-derived 6-PPD, has been frequently detected in different environments. After 6-PPDQ exposure, we here aimed to examine dynamic lung bioaccumulation, lung injury, and the underlying molecular basis in male BALB/c mice. After single injection at concentration of 4 mg/kg, 6-PPDQ remained in lung up to day 28, and higher level of 6-PPDQ bioaccumulation in lung was observed after repeated injection. Severe inflammation was observed in lung after both single and repeated 6-PPDQ injection as indicated by changes of inflammatory cytokines (TNF-α, IL-6 and IL-10). Sirius red staining and hydroxyproline content analysis indicated that repeated rather than single 6-PPDQ injection induced fibrosis in lung. Repeated 6-PPDQ injection also severely impaired lung function in mice by influencing chord compliance (Cchord) and enhanced pause (Penh). Proteomes analysis was further carried out to identify molecular targets of 6-PPDQ after repeated injection, which was confirmed by transcriptional expression analysis and immunohistochemistry staining. Alterations in Ripk1, Fadd, Il-6st, and Il-16 expressions were identified to be associated with inflammation induction of lung after repeated 6-PPDQ injection. Alteration in Smad2 expression was identified to be associated with fibrosis formation in lung of 6-PPDQ exposed mice. Therefore, long-term and repeated 6-PPDQ exposure potentially resulted in inflammation and fibrosis in lung by affecting certain molecular signals in mammals. Our results suggested several aspects of lung injury caused by 6-PPDQ and provide the underlying molecular basis. These observations implied the possible risks of long-term 6-PPDQ exposure to human health.
PURPOSE: To prepare a cosmetic capable of preventing the skin from drying up without causing glitteriness, stickiness, messy makeup, etc., of the skin and imparting the moistness to the skin by blending a cosmetic containing a specific amount of a powder with a specified glycoside. CONSTITUTION: This cosmetic is obtained by blending a cosmetic (e.g. a makeup cosmetic) containing >=2wt.% powder (e.g., talc or titanium dioxide) with a glycoside of a hydroxysalicylic acid and/or an aliphatic ester glycoside of the hydroxysalicylic acid of formula I, II or III [R1 is H or a 1-20C (un)saturated hydrocarbon; R2 is a saccharide residue]. The glycoside is preferably blended in an amount of 0.1-20wt.% based on the total amount of the cosmetic. The glycoside is preferably obtained by reacting the hydroxysalicylic acid or its aliphatic ester with an acetylated or an acetobrominated saccharide in the presence of an acidic catalyst. For example, 3-β-D-glucopyranosyloxysalicylic acid is cited as the ingredient (B).
Flexibility is a measurable physical capacity considered as a key component of physical fitness thereby contributing to the health and performance of joints and the musculoskeletal system. In recent years, there has been increasing evidence that muscle weakness is a major factor behind reduced mobility. Consequently, training muscle contractility is likely to improve mobility . Regardless of terminology and of the quality of supporting evidence, stretching emerges as an intervention that elongates the tissues in attempting to improve mobility . Shortening lengthens the tissue on two out of three axes, while stretching only lengthens the tissue on one axis out of three . All training, including movement, is, by definition, training of shortening and stretching cycles (SSCs). Ergo, resistance training is also, inherently, one way to elongate . Strength training is an active, voluntary, dynamic form of stretching. Indeed, strength training is dynamic stretching. Often, strength training is performed against external resistances, but this is not mandatory. Moreover, strength training has been shown to improve mobility in sedentary adults , .
Doxycycline 100 mg b.i.d. plus rifampin 300 mg o.d. for 12 months.
BACKGROUND: X-linked reticular pigmentary disorder (XLPDR) is a rare condition characterized by skin hyperpigmentation, ectodermal features, multiorgan inflammation, and recurrent infections. All probands identified to date share the same intronic hemizygous POLA1 hypomorphic variant (NM_001330360.2(POLA1):c.1393-354A > G) on the X chromosome. Previous studies have supported excessive type 1 interferon (IFN) inflammation and natural killer (NK) cell dysfunction in disease pathogenesis. Common null polymorphisms in filaggrin (FLG) gene underlie ichthyosis vulgaris and atopic predisposition.
CASE: A 9-year-old boy born to non-consanguineous parents developed eczema with reticular skin hyperpigmentation in early infancy. He suffered recurrent chest infections with chronic cough, clubbing, and asthma, moderate allergic rhinoconjunctivitis with keratitis, multiple food allergies, and vomiting with growth failure. Imaging demonstrated bronchiectasis, while gastroscopy identified chronic eosinophilic gastroduodenitis. Interestingly, growth failure and bronchiectasis improved over time without specific treatment.
METHODS: Whole-genome sequencing (WGS) using Illumina short-read sequencing was followed by both manual and orthogonal automated bioinformatic analyses for single-nucleotide variants, small insertions/deletions (indels), and larger copy number variations. NK cell cytotoxic function was assessed using 51Cr release and degranulation assays. The presence of an interferon signature was investigated using a panel of six interferon-stimulated genes (ISGs) by QPCR.
RESULTS: WGS identified a de novo hemizygous intronic variant in POLA1 (NM_001330360.2(POLA1):c.1393-354A > G) giving a diagnosis of XLPDR, as well as a heterozygous nonsense FLG variant (NM_002016.2(FLG):c.441del, NP_0020.1:p.(Arg151Glyfs*43)). Compared to healthy controls, the IFN signature was elevated although the degree moderated over time with the improvement in his chest disease. NK cell functional studies showed normal cytotoxicity and degranulation.
CONCLUSION: This patient had multiple atopic manifestations affecting eye, skin, chest, and gut, complicating the presentation of XLPDR. This highlights that common FLG polymorphisms should always be considered when assessing genotype-phenotype correlations of other genetic variation in patients with atopic symptoms. Additionally, while the patient exhibited an enhanced IFN signature, he does not have an NK cell defect, suggesting this may not be a constant feature of XLPDR.
Described herein is the discovery that human interleukin-1β convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 protein may be a cysteine protease like ICE and that ICE may be a human equivalent of the nematode cell death gene. Another mammalian protein, the murine NEDD-2 protein, was also found to be similar to Ced-3. The NEDD-2 gene is implicated in the development of the murine central nervous system. On the basis of these findings, novel drugs for enhancing or inhibiting the activity of ICE, ced-3, or related genes are provided. Such drugs may be useful for treating inflammatory diseases and/or diseases characterized by cell deaths, as well as cancers, autoimmune disorders, infections, and hair growth and hair loss. Furthermore, such drugs may be useful for controlling pests, parasites and genetically engineered organisms. Furthermore, novel inhibitors of the activity of ced-3, ICE and related genes are described which comprise portions of the genes or their encoded products.
Probiotics are live bacteria that offer a health benefit to the host when administered in adequate amounts. Probiotic supplementation is safe for use and has demonstrated beneficial effects for metabolic diseases such as obesity and diabetes. In this study, about 90 reproductive-aged women with PCOS will be enrolled. Participants will be randomly assigned into one of the following three groups: Metformin tablets (0.5g tid po), ProMetS probiotics powder (4g qN po), Metformin tablets (0.5g tid po) and ProMetS probiotics powder (4g qN po), for 12 weeks. Blood and stool samples will be collected before and after treatment. Fasting glucose levels, fasting insulin levels, sex hormone levels, serum lipid profiles, inflammation markers, other metabolic related parameters and change of gut microbiota and immune cells will be evaluated.
Microglia are immune-derived cells critical to the development and healthy function of the brain and spinal cord, yet are implicated in the active pathology of many neuropsychiatric disorders. A range of functional phenotypes associated with the healthy brain or disease states has been suggested from in vivo work and were modeled in vitro as surveying, reactive, and primed sub-types of primary rat microglia and mixed microglia/astrocytes. It was hypothesized that the biomolecular profile of these cells undergoes a phenotypical change as well, and these functional phenotypes were explored for potential novel peptide binders using a custom 7 amino acid-presenting M13 phage library (SX7) to identify unique peptides that bind differentially to these respective cell types. Surveying glia were untreated, reactive were induced with a lipopolysaccharide treatment, recovery was modeled with a potent anti-inflammatory treatment dexamethasone, and priming was determined by subsequently challenging the cells with interferon gamma. Microglial function was profiled by determining the secretion of cytokines and nitric oxide, and expression of inducible nitric oxide synthase. After incubation with the SX7 phage library, populations of SX7-positive microglia and/or astrocytes were collected using fluorescence-activated cell sorting, SX7 phage was amplified in Escherichia coli culture, and phage DNA was sequenced via next-generation sequencing. Binding validation was done with synthesized peptides via in-cell westerns. Fifty-eight unique peptides were discovered, and their potential functions were assessed using a basic local alignment search tool. Peptides potentially originated from proteins ranging in function from a variety of supportive glial roles, including synapse support and pruning, to inflammatory incitement including cytokine and interleukin activation, and potential regulation in neurodegenerative and neuropsychiatric disorders.
BACKGROUND: The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern of cluster headache is unclear. To acquire biological insight and to comprehend why only episodic cluster headache responds to CGRP monoclonal antibodies, we examined whether plasma CGRP changes between disease states (i.e. bout, remission and chronic) and controls.
METHODS: The present study is a prospective case-control study. Participants with episodic cluster headache were sampled twice (bout and remission). Participants with chronic cluster headache and controls were sampled once. CGRP concentrations were measured in plasma with a validated radioimmunoassay.
RESULTS: Plasma was collected from 201 participants diagnosed with cluster headache according to the International Classification of Headache Disorders, 3rd edition, and from 100 age- and sex-matched controls. Overall, plasma CGRP levels were significantly lower in participants with cluster headache compared to controls (p < 0.05). In episodic cluster headache, CGRP levels were higher in bout than in remission (mean difference: 17.1 pmol/L, 95% confidence interval = 9.8-24.3, p < 0.0001). CGRP levels in bout were not different from chronic cluster headache (p = 0.266).
CONCLUSIONS: Plasma CGRP is unsuitable as a diagnostic biomarker of cluster headache or its disease states. The identified reduced CGRP levels suggest that CGRPs role in cluster headache is highly complex and future investigations are needed into the modulation of CGRP and its receptors.
A system of the present invention is a multi-user-based health care service system, in which a user directly checks and manages health in a health center. That is, several users log in individually within the health center. After logging in, the user checks his/her basic information and measures various bio-signal data such as his/her blood sugar, blood pressure, pulse, body temperature, electrocardiogram, oxygen saturation, body composition, muscle mass, activity level, etc. through a bio-signal sensor to be transmitted and stored to a storage server through a network. A medical professional or health care professional monitors data in real time, analyzes a health state through the user's personal information and the measured bio-signal data, and predicts a future health state. The medical professional or health care professional also provides exercise management, diet management, and lifestyle services for a healthy life.
Automatic system for efficient delivery of biologics into target organs of zebrafish larvae for high-throughput in vivo screening. The system includes a reservoir containing zebrafish larvae immersed in a hydrogel in its liquid state. A microfluidic component removes a droplet of the hydrogel having a single zebrafish larva contained therein and deposits the droplet on a surface for receiving an array of hydrogel droplets. Structure or substances is provided for inducing the larva to assume a dorsal or lateral orientation within the droplet. A cooler cools the surface to solidify the hydrogel droplets thereby to immobilize the larvae for observation by an optical arrangement that identifies target organs in each larva using an image template-matching algorithm. A pressure driven microinjection needle injects biologics into the target organ of the zebrafish larva for screening studies.
Patients with stage II or stage III colorectal cancer (CRC) were randomly assigned to two arms. In arm B, patients accepted curative resection + mFOLFOX6 alone.
The invention discloses an african swine fever virus K205R protein specific B cell epitope polypeptide and application thereof, and belongs to the technical field of molecular immunology. In order to provide an African swine fever virus protein polypeptide antigen with an immune protection function or a serological diagnostic value. The amino acid sequence of the epitope polypeptide disclosed by the invention is shown as SEQ ID NO. 1. The ASFV K205R protein specific B cell epitope synthesized polypeptide, synthesized epitope polypeptide coupled antigen and antigen epitope fusion expression protein as antigen can be used for specifically detecting an anti-ASFV K205R protein antibody generated after body immunity or infection. Can be used for ASFV infection diagnosis, vaccine immune effect evaluation and as vaccine component for inducing immune pigs to produce specific antibodies.
[PROBLEMS] To provide a method of activating the function of cells to be transplanted and elevate the take and proliferation efficiencies of the cells. [MEANS FOR SOLVING PROBLEMS] Cells to be transplanted are stored in a static electric field atmosphere. The static electric field atmosphere is achieved by applying an alternating current or direct current voltage of from 100 to 10000 V on an electrode. The storage temperature in the static electric field atmosphere is from -30 to 40oC. Namely, cells can be activated without freezing at such a low temperature of -10 to -1oC as being frozen unless using the static electric field atmosphere. This method is usable in the fields of transplantation, regeneration therapy, gene therapy, fundamental studies and so on.
INTRODUCTION: This study aimed to evaluate postoperative pain intensity following glide-path preparation using the ProGlider (PG) and WaveOne Gold Glider (WOGG) systems in asymptomatic teeth with necrotic pulp and periapical lesions.
METHODS: In this randomized clinical trial (ClinicalTrials.gov ID: NCT05955742) maxillary and mandibular molars with asymptomatic apical periodontitis of 78 patients (age, 18-65 years) were included. The patients were randomly divided into 3 groups: control (n = 26), PG (n = 26), and WOGG (n = 26). All the systems were used according to the manufacturer's instructions, and all the root canal treatments were completed by a single operator within 2 sessions. Postoperative pain was assessed using a numerical rating scale at 6, 12, 18, 24, 48, and 72 hours. Analgesics administered and abscess formation were also recorded. Statistical analyses were performed using the Mann-Whitney U, Bonferroni Dunn, Friedman, Chi-square, and Fisher exact tests.
RESULTS: The postoperative pain at 12 and 18 hours was lower in the WOGG group than in the other groups (P < .05). The postoperative pain scores at 6 and 24 hours were higher among women than among men (P < .05). The highest postoperative pain scores were observed at 6 hours (P < .05).
CONCLUSIONS: The WOGG glide-path file system was associated with less postoperative pain than the other systems. Abscess formation and analgesic use were higher in the PG group than in the other groups. Postoperative pain was greater in women than in men.