anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Rheumatoid arthritis (RA) is a persistent systemic disease. WHO (World Health Organization) commented that a crucial goal of heath care for RA is prevention of loss of daily function by patients' self-management (SM) skills; however, a comprehensive rheumatoid arthritis self-management program for RA patients' day-to-day self-managing is limited in Taiwan. The aims of the study are: (1) to implement the rheumatoid arthritis self-management program, and (2) to determine the effectiveness of the program with 6 months follow-up. The project will design to implement and evaluate the rheumatoid arthritis self-management program for RA patients using two groups experimental design. A medical center in northern Taiwan will be selected and patients who visited the RA departments will be eligible for the study if they are: (1) diagnosed with RA, (2) age of 20 years or over, (3) disease considered have been stable for at least 3 months, and (4) able to understand and comply with the study treatment. After completion of baseline data, patients will be randomly allocated to the intervention or control group using a computerized allocation procedure and follow the CONSORT flow diagram. Control patients received usual care, and the intervention group will receive the 6-week rheumatoid arthritis self-management program which based on self-efficacy theory. The independent variable of the program will be the four information include mastery experience, social modeling, social persuasion and physical and emotional states, and the strategies involve education, goal setting and attainment, self-monitoring, and phone calls. All participants will follow up for 6 months, and the data will be collected at the baseline, and 2, 3, and 6 months. The statistics with the GEE (generalized estimating equation) analysis will be used to evaluate the outcomes such as the disease activity (DAS-28), arthritis self-efficacy (ASE), physical functioning (MHAQ), quality of life (SF-36), and self-management behaviors. Through enhance the capacity of self-management program for the RA cases to reduce the health care utilization and patients' and caregivers' burden.
The patients will receive three applications of FMT consisting of 50 g cryopreserved, homogenized faeces from healthy donors. The faecal material will be dispensed into double-coated, acid-resistant enterocapsules or cryobags. Faeces will be screened according to international guidelines.
PCT No. PCT/EP94/03348 Sec. 371 Date May 9, 1996 Sec. 102(e) Date May 9, 1996 PCT Filed Oct. 12, 1994 PCT Pub. No. WO95/11210 PCT Pub. Date Apr. 27, 1995Fatty alcohols of the formula I R1OH (I) wherein R1 is a saturated or unsaturated, linear or branched aliphatic radical having from about 8 to about 22 carbon atoms are made by an improvement in the process which comprises hydrogenating a fatty acid, a fatty acid methyl ester or a combination thereof to form a fatty alcohol. The improvement comprises removing a head fraction from the fatty acid, the fatty acid methyl ester or the fatty alcohol in such a quantity that the fatty alcohol has an iodine value of from about 20 to about 110 and less than about 4.5% by weight of conjugated compounds.
<P>PROBLEM TO BE SOLVED: To provide an antiallergic composition and a bleaching composition each containing a lactobacillus fermentation extract obtained by fermenting a raw material, i.e. beans, rooibos tea or rose.  <P>SOLUTION: The antiallergic composition contains a lactobacillus fermentation composition that is obtained by inoculating lactobacillus into a medium containing at least one of soybean, red bean and rooibos tea followed by fermentation culture thereof. The bleaching composition contains a lactobacillus fermentation composition that is obtained by inoculating lactobacillus belonging to the genus Lactobacillus into a medium containing at least one of rooibos tea and rose followed by fermentation culture thereof, or contains a lactobacillus fermentation composition that is obtained by inoculating lactobacillus belonging to the genus Leuconostoc or Lactobacillus casei subsp. casei into a medium containing soybean followed by fermentation culture thereof. The antiallergic composition and the bleaching composition are enhanced in antiallergic effect and bleaching effect respectively owing to the corresponding lactobacillus fermentation composition.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patients of the study arm will receive rituximab (375mg/m2) induction and subsequently everolimus-based immunosuppressive therapy. Everolimus will be given with an initial dose of 1 mg bid within 24 hrs after reperfusion, adjusted to a target trough blood level of 6-10 ng/ml for the first 6 months after transplantation.
PROBLEM TO BE SOLVED: To increase profit by providing prescriptions of herbal medicines through a communication network. SOLUTION: A server system installed at a herbal-medicine seller is connected to client computers installed at a doctor, a pharmacist, etc., through the Internet. Information specifying a prescription applicant for herbal medicines in inputted to a client computer. On the screen of the client computer, a chief complaint table, an inquiry table, and a tongue examination table each containing check items are displayed and corresponding items of those tables are selectively clicked according to symptoms of a patient. A prescription request including the items is sent to the server system through the Internet and a prescription of herbal medicines complying with the prescription request is generated under the control of the server system. The generated prescription is sent to the client computer through the Internet.
Practical blood flow restriction (PBFR) is a new technique of reducing the venous return using a band with a pressure that is applied using a perceived pressure scale. The studies that investigate the acute effect of using PBFR and regular high intensity exercises on the level of growth hormone (GH) and blood lactate (BL) after lower extremity training in collegiate athletes are scarce. Therefore, this study aimed to investigate the acute effect of a single session low load resistance exercises with PBFR compared to a high load resistance exercises without PBFR on the levels of GH and BL. A convenience sample of collegiate athletes were allocated to either an experimental group that performed low resistance exercises with PBFR or a control group that performed high resistance exercises without PBFR. The levels of GH and BL were examined in 3 time points: pre-training, immediate post-training, and 15 minutes post-training for both groups. Analysis of Variance (ANOVA) was used to assess the main and interaction effects of the groups.
Depression diagnosed and volunteer to participate 39 cases who between the ages of 15-21 included. All participants were recruited and randomly assigned into two groups, the osteopathy group (OG) and the placebo group (PG). Stimulation on the sympathetic truncus and prevertebral ganglia were performed in the OG group. The stimulation of the PG group was performed with a lighter touch and a shorter duration in similar areas. Each participant was filled in the demographic data form, Beck Depression Scale and State and Trait Anxiety Inventory (STAI Form - 1 and Form - 2) before the application. Emotional state visual analog scale and STAI Form - 1 was filled and blood pressure and pulse measurement were made and saliva sample was taken before application, immediately after application and 20 minutes after application.
According to the present invention, a remote real-time integrated management system of a bus platform having an infection prevention function connects a plurality of bus platform terminal devices and glass repairers to a bus platform management center through a network. An infection prevention bus platform management center realizes a real-time integrated management program. The real-time integrated management program performs glass breakage management and infection prevention functions in real time. The glass breakage management function requests location-based glass repair when glass breakage is detected, and sends a request for repair costs to a competent government office. The infection prevention function measures a user′s body temperature with a thermal imaging camera, generates a warning when a user with a symptom of a fever higher than the normal body temperature is detected, and sends warning information of a fever person to the competent government office by taking an image of the fever person with a CCTV camera. Therefore, the spread of infection through multi-use facilities can be prevented by measuring the body temperature of users who use the bus platform and warning of a fever person.
During the ROP examination, Dr. Harvery Karp's "The Happiest Baby", which consists of only intrauterine sounds, is a group of babies who are listened to. The experimental group will start playing music 3 minutes before the start of the process. The examination begins with the insertion of the speculum into the eye. The duration of the examination depends on the visibility of the vascularity in the retina and the examination will end with the removal of the speculum from the eye. Music will continue to play during the ROP exam. The voice recorder that will play The Happiest Baby will be placed 25 cm away from the baby. In the study, the music volume will be set as 45-50 decibels.
Dendritic cell (DC)-based immunotherapy is a promising approach to augment tumor antigen-specific T cell responses in cancer patients. However, tumor escape with down-regulation or complete loss of target antigens may limit the susceptibility of tumor cells to the immune attack. Concomitant generation of T cell responses against several immunodominant antigens may circumvent this potential drawback. In this phase I/II clinical trial, the investigators determined the immunostimulatory capacity of autologous DC pulsed with multiple T cell epitopes derived from four different prostate-specific antigens in patients with advanced hormone-refractory prostate cancer. Autologous DC of HLA-A\*0201-positive patients are loaded with antigenic peptides derived from prostate stem cell antigen, prostatic acid phosphatase, prostate-specific membrane antigen, and prostate-specific antigen. A strict quality control concerning the expression of surface markers and the migratory capacity of the DC secured optimal stimulatory capacity. DC were applied intradermally six times at biweekly intervals followed by monthly booster injections. Tolerability and PSA response will be investigated. Antigen-specific immune responses will be quantified.
Novel vaccine therapies, and prophylactic treatments of atherosclerotic diseases involving use of immugones comprising apolipoproteins, or fragments thereof, having at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase. A preferred example of one such apolipoprotein is Apolipoprotein C-III (ApoCIII). The vaccines of the present invention, comprising said immunogens, prevent atheroslerosis plaque formation, thereby reducing coronary or cerebrovascular disease.  Artherosclerosis is also treated by selectively inhibiting the activity of specific apolipoproteins e.g. ApoCIII in a human, comprising administering an agent which results in the selective inhibition of the apolipoprotein activity to a human. Atherosclerosis is also treated by active or passive vaccination, by administering an antibody that is capable of binding to a apoliprotein e.g.  ApoCIII that has at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase.
Participants will be treated with Lokomat for 40 minutes, twice a week for 5 weeks, and RAGT with a body weight support system and combined TBT for 40 minutes each session 3 times a week. During RAGT, 30-40% of each participant's body weight will be taken with the body weight support system. In patients without drop foot and knee instability in the sessions after the first session, the body weight will be reduced by 10% and progression will be achieved. The speed of the treadmill will be adjusted between 1.2-2.6 km/h and the maximum speed tolerated by the patient will be reached during the sessions. TBT exercises 3 times a week for 40 minutes (weight transfer to the paretic leg during sitting and standing, weight transfer during sitting and standing with or without an assistive device) will be personalized according to the patient. Progression of exercises will be provided by adding upper extremity and trunk activities in addition to exercises.
Research has consistently shown that exposure to extreme environments (such as high altitude stays) may affect cognitive function. For logistical reasons and to control the experimental set-ups, most of these examinations are carried out in the laboratory. By testing under such controlled conditions, researchers can remove any co-foundational factors and isolate the cause of stress, thereby better understanding the mechanisms by which impairment can occur. However, when people are exposed to such environments in the "real world" (such as altitude), they often experience a number of other additional stressors at the same time, which can also affect their performance. Surprisingly, however, little attention has been paid to the study of these additional stressors in combination.

Although the oxygen content remains constant at various altitudes (20.93%), the air pressure decreases exponentially as the altitude increases. As a result, the oxygen partial pressure in arterial blood and tissue is reduced (hypoxia), leading to a deterioration in both physical and cognitive performance. Hypoxic conditions also alter the perception of pain, which may be particularly relevant for patients suffering from hypoxic conditions. According to the authors' knowledge, there is limited literature investigating and comparing simulated and real psychophysiological responses.
Subjects will receive 60 mg edoxaban in the morning on Days 1-2. On Day 3 and 4, they will receive a single dose of 60 mg edoxaban, followed 3 hours later by a single dose of 50 mg PER977 or placebo (n=10).
The control group will comprise 250 subjects. After the baseline assessment, subjects will be randomized in one of the three intervention arms or in the control group. Individuals in the control group will undergo the same baseline and follow-up evaluations as subjects in the intervention arms and will receive the same leaflet about healthy lifestyles with information about the possibility to seek help for unhealthy, suicidal behaviour and mental health problems. In this arm, no additional intervention will be performed although the possibility of seeking help from mental health resources will be available.
PROBLEM TO BE SOLVED: To provide an ameliorant for renal functions daily and tastily ingestible in the same manner as that of usual tea. SOLUTION: This ameliorant for the renal functions is obtained by mixing the tea material with liquors and an acid fermented milk, aging the resultant mixture and extracting the aged tea material with an aqueous solvent as an active ingredient. The resultant ameliorant for the renal functions is capable of maintaining the renal functions normal even when, e.g. a meal with a high fat content is ingested. The tea material is preferably one or more kinds selected from green teas, Chinese teas, black teas and barley teas. The liquors are preferably one or more kinds selected from Sake, wines, whiskeys, brandies, Shaoxing and Shochu (Japanese distilled spirit). Furthermore, the acid fermented milk is preferably yogurts, acid milk beverages or lactic acid bacteria beverages.
Pediatric patients meeting initial eligibility criteria will be identified through the databases for each clinic (n = approximately 50 survivors in each clinic). A letter explaining the purpose of the study will then be sent to the parents of these patients. Interested parents will be invited to contact study personnel by phone or email for a thorough review of the study and to schedule a screening appointment.

After obtaining written informed consent and assent (from parents and child, respectively), screening procedures will include administration of an abbreviated intellectual test battery, two working memory tasks, and a computerized attention measure to the survivor. Parents will complete questionnaire measures regarding their child's adaptive, behavioral, emotional, and attentional functioning; follow-up interviewing will be conducted to clarify any potential problems identified on the questionnaires. The entire screening procedure is estimated to take approximately 60 minutes for the survivor and 30-45 minutes for parents. To maximize efficiency, a research assistant will complete testing with the child and a psychologist will explain the questionnaire measures to the parent and conduct any follow-up interviewing.
Very light breakfast (VLB) for one week then crossover to standard breakfast (SB) for one week while taking either 1 or 2 20 mg capsules of methylphenidate once per day based on the dosage the child had taken in the month prior to study start. VLB is defined as 150 kcal for children age 6-9 and 180 kcal for children age 10-12. SB is defined as 450 kcal for girls age 6-9, 490 kcal for boys age 6-9, 550 kcal for girls age 10-12, and 600 kcal for boys age 10-12.
This is a prospective, multicentre, cohort study that will assess a new diagnostic management strategy for suspected Deep Vein Thrombosis in outpatients. The new diagnostic strategy is designed to reduce the use of ultrasound testing on the day of presentation, and reduce repeat ultrasound testing a week after an initial normal test. Less ultrasound testing will be performed because: i) more patients will have deep vein thrombosis excluded by combinations of Clinical Pretest Probability and D-dimer results on the day of presentation; and, ii) in those who still need an ultrasound, a repeat ultrasound a week after a normal result will only be performed if the D-dimer result is markedly abnormal at initial presentation. The safety of this management strategy will be established by demonstrating a very low rate of proximal Deep Vein Thrombosis or Pulmonary Embolism during 90 days follow-up in patients who had anticoagulant therapy withheld in response to negative diagnostic testing. Diagnostic test utilization will be assessed. All clinical outcomes will be adjudicated by a central independent adjudication committee that will be blind to initial D-dimer measurements and patient management.
Adults

The recommended starting and target dose for aripiprazole tablets is 10 or 15 mg/day administered on a once-a-day schedule without regard to meals. Aripiprazole has been systematically evaluated and shown to be effective in a dose range of 10 to 30 mg/day, when administered as the tablet formulation; however, doses higher than 10 or 15 mg/day were not more effective than 10 or 15 mg/day. Dosage increases should generally not be made before 2 weeks, the time needed to achieve steady-state [see Clinical Studies (14.1)] . 

Maintenance Treatment: Maintenance of efficacy in schizophrenia was demonstrated in a trial involving patients with schizophrenia who had been symptomatically stable on other antipsychotic medications for periods of 3 months or longer. These patients were discontinued from those medications and randomized to either aripiprazole 15 mg/day or placebo, and observed for relapse [see Clinical Studies (14.1)] . Patients should be periodically reassessed to determine the continued need for maintenance treatment. 

Adolescents

The recommended target dose of aripiprazole tablets is 10 mg/day. Aripiprazole was studied in adolescent patients 13 to 17 years of age with schizophrenia at daily doses of 10 mg and 30 mg. The starting daily dose of the tablet formulation in these patients was 2 mg, which was titrated to 5 mg after 2 days and to the target dose of 10 mg after 2 additional days. Subsequent dose increases should be administered in 5 mg increments. The 30 mg/day dose was not shown to be more efficacious than the 10 mg/day dose. Aripiprazole tablets can be administered without regard to meals [see Clinical Studies (14.1)] . Patients should be periodically reassessed to determine the need for maintenance treatment. 

Switching from Other Antipsychotics

There are no systematically collected data to specifically address switching patients with schizophrenia from other antipsychotics to aripiprazole or concerning concomitant administration with other antipsychotics. While immediate discontinuation of the previous antipsychotic treatment may be acceptable for some patients with schizophrenia, more gradual discontinuation may be most appropriate for others. In all cases, the period of overlapping antipsychotic administration should be minimized.
BACKGROUND: While traditional metallic cerclage remains the primary method in clinical application, non-metallic cerclage systems have recently gained popularity due to low risks of soft tissue irritation and bone intrusion. The objective of this study was to assess the performance of a novel non-metallic suture-based cerclage in comparison to traditional metallic cerclage cables for fixation of periprosthetic femoral fractures.
METHODS: An extended trochanteric osteotomy was performed on eight pairs of cadaveric femora, followed by reduction using either metallic cerclages (Group I) or the suture-based cerclage (Group II). A modular tapered fluted stem was then implanted in each specimen. The fragment translation during canal preparation and stem implantation was quantified using laser-scanning. Subsequently, each specimen underwent 500 cycles of multiaxial loading, with fragment translation and stem subsidence measured using a motion capture system.
FINDINGS: Following stem implantation, specimens in Group II exhibited a significantly greater lateral fragment translation (466 μm vs 754 μm, p = 0.017). However, there were no significant differences in anterior and distal translation between groups (p > 0.05). During multiaxial loading, the average stem subsidence in Group I was 0.36 mm (range, 0.04-1.42 mm), compared to 0.41 mm (range, 0.03-1.29) in Group II (p > 0.05). No significant difference was found in fragment translations between the two groups (p > 0.05).
INTERPRETATION: The suture-based cerclage system exhibited comparable biomechanical performance in fixation stability to conventional metallic cerclage cables. Yet, it was associated with a larger residual lateral gap between the fragments following stem implantation. Ultimately, the choice of fixation method should account for multiple factors, including patient characteristics, surgeon preference, and bone quality.
PURPOSE:To obtain the subject preparation maintaining sustained release of medicine even after long-term preservation, keeping pharmacodynamic effects for many hours after application by blending an antiphlogistic medicine having percutaneous absorption ability with a base containing analgesic medicine and microcapsule having sealed a liquid diluent. CONSTITUTION:At least one medicine 15 of an antiphlogistic medicine and an analgesic medicine (e.g. methyl salicylate having percutaneous absorption ability is added to a base 12 prepared by blending an endothermic agent (e.g. kaolin) with a water retaining agent (e.g. glycerol), a tacky agent (e.g. polybutene) or an excipient (e.g. polysorbate).The blend is mixed with microcapsules 14 such as ethyl cellulose having 5mu average particle diameter having sealed a liquid diluent (e.g. water) prepared by interfacial precipitation method to give a plaster composition, which is applied to a sheetlike substrate (e.g. nonwoven fabric) 11. The plaster composition is coated with a protecting film (e.g. cellophane) 13 to give an intermediate preparation for antiphlogistic analgesic for percutaneous administration having sustained release even after long-term preservation.