anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To utilize an emulsified compsn. as cosmetics or a lotion for external use to the skin by using a hydrolyzate of elastin having >=200,000mol.wt. so as to improve the emulsion stability, water and moisture retentivity of the compsn. CONSTITUTION:Elastin is enzymatically hydrolyzed to remove low mol.wt. matter and the resulting hydrolyzate having >=200,000mol.wt., preferably about 1-2 million average mol.wt. is added to an aq. phase by about 0.1-5wt.%, preferably about 1-10wt.%. Higher alcohol such as cetanol, higher fatty acid or other oily base is further added and emulsified to obtain an oil-in-water type or water-in-oil type emulsified compsn. A skin nutrient, perfume and a physiologically active substance may be added as required. The emulsified compsn. has more satisfactory water and moisture retentivity and emulsion stability than low mol.wt. elastin, does not irritate the skin and is applied with good feeling.
Methods, apparatuses and systems are described for determining a readiness of a user. The methods may include receiving physiological data corresponding to one or more physiological parameters of the user. The methods may also include receiving user input data corresponding to one or more subjective user state parameters of the user. The methods may also include assigning a respective component score to each of the received physiological data and user input data. The methods may further include assigning a respective weight to at least one of the one or more physiological parameters or one or more subjective user state parameters of the user. The methods may also include deriving a readiness score for the user based at least in part on the component scores of the corresponding weights. The derived readiness score may be communicated to the user via a display device.
BACKGROUND: Shouhui Tongbian capsule (SHTB) has been widely used for the treatment of constipation. There are few studies on SHTB at present. The current study aimed to explore the effects of multi-components compatibility of SHTB for efficacy enhancement and toxicity reduction and evaluate its molecular biological mechanisms in the treatment of slow transit constipation (STC).
METHODS: Ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to quantify 17 anthraquinone components in different compatible systems of SHTB. Network pharmacological analysis was used to probe the potential mechanisms of SHTB in treating STC. In addition, an animal experiment combined with western blot analysis was performed to further validate the predicted results.
RESULTS: After compatibility, the dissolution of 13 components with good effects in treating constipation increased, while the dissolution of 3 components with hepatotoxicity decreased. Overall, 145 common targets of 13 synergistic components and constipation were identified. A synergistic component-target-disease network showed that chrysoobtusin, obtusifolin, emodin, obtusin and 2-hydroxyl emodin-1-methyl ether were the potential key synergistic components. A protein-protein interaction network analysis identified 91 targets, and an analysis of topological characteristics was conducted to confirm the core targets. Gene Ontology function revealed that the 13 synergistic components for the treatment of STC mainly played roles via protein phosphorylation, positive regulation of phosphorylation, phosphotransferase activity, kinase activity and protein kinase activity, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these components were enriched in pathways in cancer, MAPK signaling pathway, IL-17 signaling pathway, NF-κB signaling pathway, etc. The results of animal experimental validation showed that SHTB significantly reduced the expression levels of p-p38 and p-ERK proteins in the colon tissue of the STC rats.
CONCLUSION: This study preliminarily demonstrated that efficacy enhancement and toxicity reduction of SHTB could be achieved after compatibility, which expounded the connotation of compatibility theory of traditional Chinese medicine from the perspective of chemical composition, reflecting the rationality and scientificity of compatibility theory. Meanwhile, the study also revealed the core targets and potential molecular biological mechanisms of SHTB in the treatment of STC, which may serve as a reference for subsequent studies and clinical applications of SHTB.
Cellulose acetate hydrogen phthalate containing 5-25 per cent weight of free carboxyl is prepared by dissolving phthalic anhydride in pyridine, adding cellulose acetate containing 33 per cent acetyl and heating on a steam bath for 14-18 hours.  The reaction mixture is diluted with acetone, poured into 5 per cent hydrochloric acid and the resultant precipitate washed and dried. In the form of its water-soluble salts it may be incorporated in gelatin capsules which, after subsequent tanning in 1 per cent aqueous formaldehyde, to render them resistant to dissolution in the stomach, are thereby capable of rapid disintegration in the intestinal secretions.  The sodium, potassium, ammonium and lithium salts and salts of organic amines such as diethanolamine, ethylene diamine, diethylene triamine and triethylene tetramine are specified.ALSO:A medicinal capsule shell consists of a tanned gelatin envelope which contains in dispersed admixture with the gelatin, particles of a material resistant to dissolution in the stomach but capable of dissolving in the intestinal secretions.  Such materials are the water-soluble salts of cellulose acetate hydrogen phthalate containing 5-25 per cent free carboxyl and they may be used in the proportion of 5-10 per cent wt. of the shell.  Examples are the sodium, potassium, ammonium and lithium salts, and the salts of organic amides such as diethanolamine, ethylene diamine, diethylene triamine and triethylene tetramine.  In an example finely ground cellulose acetate hydrogen phthalate is mixed with sufficient sodium bicarbonate to neutralize the phthalate and the mixture dissolved in water Gelatin is soaked in aqueous glycerin, the phthalate mixture added and the product maintained at 600 DEG C. The phthalate should dissolve and the pH of the solution should not exceed 7-7.5.  This solution is suitable for preparing capsules which are subsequently tanned as, for example, by immersion in 1 per cent aqueous formaldehyde solution followed by washing and drying.
OBJECTIVE: To combine all literature describing cases of isolated fallopian tube torsion in adult non pregnant patients in a systematic manner, to optimize knowledge and practice both for diagnosis and management.
STUDY DESIGN: EMBASE and PubMed databases were searched for the terms 'tubal' OR 'fallopian tube' AND 'isolated' AND 'torsion' from the inception of these databases to July 5, 2023. All case reports or case series of adult patients (18 years or older) with isolated fallopian tube torsion were included. Exclusion criteria included: all other study types; cases involving children and adolescents (less than 18 years old); pregnant patients of all trimesters; tubo-ovarian torsion; studies not published in English; duplicates and those not available in text. Following the database search, two authors independently screened the studies and search results were subsequently reported in accordance with PRISMA guidelines. Data was extracted independently by two authors and analysed using Excel. All cases were assessed for bias using a modified version of the tool proposed by Murad et al. RESULTS: 92 unique articles enrolling 131 individual cases were included in this systematic review. Isolated fallopian tube torsion most commonly occurs during reproductive ages between 18 and 45 years. It is uncommon in postmenopausal women. The most common presenting symptoms include unilateral lower abdominal or pelvic pain along the affected side with nausea and vomiting. Risk factors can be intrinsic or extrinsic and can include conditions such as hydrosalpinx, sterilization, pelvic inflammatory disease or cysts. Ultrasound is the optimal imaging modality however Computed Tomography and Magnetic Resonance Imaging can also be used. Imaging in general has low sensitivity, however isolated fallopian tube torsion can be identified with appropriate expertise. The gold standard for isolated fallopian tube torsion management is laparoscopy and detorsion however currently, the most common intervention performed is salpingectomy.
CONCLUSIONS: Isolated fallopian tube torsion is a rare but important gynaecological emergency with significant fertility implications. This study summarizes the most common presentations, investigation findings and surgical interventions in patients with isolated fallopian tube torsion. This study also emphasizes the importance of clinicians maintaining a high degree of suspicion and low threshold for early laparoscopic intervention to retain fertility.
House dust mites (HDM) are common aeroallergens linked to airway inflammation and remodeling in asthma. Protease-activated receptor 2 (PAR2) and thymic stromal lymphopoietin (TSLP) may mediate these immune responses. However, how the epithelium influences fibroblasts toward airway remodeling remains unclear. We hypothesize that HDM stimulates human bronchial epithelial cells (HBECs) to produce TSLP via PAR2 activation, driving fibroblasts toward remodeling processes. HBECs were treated with HDM, with or without the PAR2 antagonist FSLLRY-NH2 (FSL), and TSLP expression was measured by qPCR and ELISA. Phosphorylation of MAPKs was assessed by western blotting. Human lung fibroblasts (HLFs) were exposed to recombinant TSLP or conditioned medium (CM) from HDM-stimulated HBECs, with or without anti-TSLP antibodies. Fibroblast proliferation and collagen production were assessed as remodeling markers. HDM increased ERK phosphorylation (not p38 or JNK) and TSLP expression at mRNA and protein levels. FSL preincubation significantly reduced ERK phosphorylation and TSLP production: HDM-stimulated CM induced fibroblast proliferation and collagen production, effects suppressed by anti-TSLP or FSL. Direct treatment with recombinant TSLP also promoted fibroblast proliferation and collagen synthesis. These findings suggest that HDM promotes HBEC-to-HLF paracrine interactions via PAR2-ERK-TSLP axis, participating in airway remodeling. PAR2 antagonists may represent potential therapeutic targets for HDM-induced remodeling processes.
OBJECTIVES: To assess and evaluate the mental health and psychological changes in weight loss injection users and bariatric surgery.
METHODS: A descriptive and analytical cross-sectional study was conducted from July 2022 to December 2022. A self-administered questionnaire was given among participants using social media platforms. The questionnaire included socio-demographic characteristics, weight-loss-related characteristics, General Anxiety Disorder (GAD-7) to measure anxiety, and Patient Health Questionnaire (PHQ-9) to measure depression experienced by the patients.
RESULTS: Of the 721 patients, 73.9% were females, and 30.1% were aged between 30 to 39 years old. The prevalence of patients who underwent weight loss by surgery and injection was 47.7% and 41.2%, respectively. Overall, symptoms of anxiety and depression were detected in 19.7% and 24%, respectively. Independent risk factor of anxiety and depression was the symptom of the psychiatric disorder prior to surgery, while the independent protective factor for anxiety and depression was older age. Depression was higher in weight loss injection users.
CONCLUSION: Nearly one-quarter of the study population experienced anxiety or depression following weight loss treatment. Weight loss treatment by injections increases the risk of depression. However, improved self-confidence, mood, and relationships with family and friends were some of the positive changes exhibited by the patients after undergoing weight loss treatment. Appropriate psychiatric evaluation is necessary before and after weight loss intervention.
BACKGROUND: Intrathecal diamorphine is believed to provide postoperative analgesia but is associated with adverse effects such as nausea and vomiting. There is little evidence of synthesis regarding intrathecal diamorphine in the contemporary literature. We performed a systematic review, meta-analysis with meta-regression and trial sequential analysis to determine the magnitude of intrathecal diamorphine efficacy and safety.
METHODS: We systematically searched the literature for trials comparing intrathecal diamorphine with a control group in patients undergoing all types of surgery. The primary efficacy and safety outcomes were intravenous morphine consumption and incidence of postoperative nausea and vomiting at 24 h following surgery, respectively.
RESULTS: Twelve trials were identified, which included data for 712 patients. Intrathecal doses of diamorphine ranged from 100 μg to 2500 μg. Intravenous morphine consumption at 24 h postoperatively was significantly reduced in the intrathecal diamorphine group, with a mean difference (95%CI) of -8 mg (-11 to -6), I2 = 93%, p < 0.001. There was a significant difference between three intrathecal diamorphine dosing subgroups but without correlation: mean differences (95%CI) -1 mg (-3-0), -26 mg (-40 to -11) and -6 mg (-15-4) in patients receiving doses of 0-200 μg, 201-400 μg and > 400 μg, respectively (p = 0.003). Intrathecal diamorphine increased postoperative nausea and vomiting with a risk ratio (95%CI) of 1.37 (1.19-1.58), I2 = 7%, p < 0.001. There were no differences in postoperative nausea and vomiting between the three intrathecal diamorphine dosing subgroups. There was no correlation observed with meta-regression of the primary efficacy and safety outcomes. The quality of evidence for all outcomes was very low.
CONCLUSION: There is very low level of evidence that intrathecal diamorphine provides effective analgesia after surgery, while increasing postoperative nausea and vomiting with doses > 200 μg.
1. Title: The role of capsaicin in treatment of rhinogenic headache
2. Description: Capsaicin (8- methyl-N-vanillyl-6-nonenamide) has been demonstrated to have a therapeutic effect in idiopathic rhinitis, migraines and cluster headaches. We hypothesize that capsaicin has a therapeutic effect on rhinogenic headaches as well. This study aims to evaluate capsaicin impact on headaches attributed to the nose and paranasal sinus distribution.
3. Interventions, evaluations, and follow-up: Subjects are recruited from an Otolaryngology clinic, where a formal headache questionnaire is administered in-office, and standard endoscopy is performed in office to rule out confounding causes of headache and sinonasal disease. Written instructions are provided and consent obtained. A symptom journal is provided. Subjects are randomly selected to receive two bottles of either eucalyptol spray (placebo) or sinus buster (capsaicin) spray and are blinded to the content of the spray bottle. They are instructed to use the nasal spray one to two times daily. Subjects are permitted to continue to take headache medication as needed, but it must be recorded in their symptom journal. The journal is completed daily, and includes medication use, a headache pain score, and side effect log. Additionally, subjects fill out SinoNasal Outcome test (SNOT)22 at 2 weeks, 4 weeks, and 8 weeks. Weekly emails are sent to remind subject to fill out their journal. A phone call is made to the subject to survey them on progress at 2 and 6 weeks. Follow up visits are scheduled at 4 weeks and 8 weeks, or sooner if problems arise. A standard nasal endoscopy is performed at the first and last visit.
4. Additional data that would be tracked: Quality of life score as measured by SNOT-22 scores, treatment failure and drop-outs, and objective changes in sinus endoscopy.
This group will receive the Brighter Bites intervention throughout the study implementation. The intervention includes fruit and vegetable distributions of \~20lbs. for teachers and families, healthy recipe tastings, and nutrition education.
Dual sensory impairment, commonly referred to as combined hearing and vision loss, can stem from a diverse spectrum of conditions, each presenting with its unique set of clinical characteristics. Our understanding of dual sensory impairment has expanded significantly in the past decade, broadening the scope of genetic differential diagnoses, including genes such as CEP250, ARSG, TUBB4B, CEP78, and ABHD12. A case series including three patients from two families with genetically diagnosed CEP78-associated cone-rod dystrophy was identified. We collected and reviewed their clinical records, imaging data, and genetic testing results. In addition, a comprehensive literature review was conducted on the phenotype and the genetic testing modality employed in all published CEP78 cases through a PubMed search using the keyword "CEP78." A retinal dystrophy panel detected a novel homozygous CEP78 pathogenic variant (c.1447C>T, p.Arg483*) in siblings-Cases 1 and 2-from Family 1. Both teenagers have a clinical diagnosis of cone-rod dystrophy with presumed normal hearing. Case 3 from Family 2, diagnosed with cone-rod dystrophy and early-onset hearing loss, was found to carry a CEP78 pathogenic variant (c.1206-2A>C) and a likely pathogenic variant (c.856_857del, p.Leu286Glyfs*12) also through panel-based genetic testing. Intriguingly, neither of these variants was reported in an affected sibling's clinical whole-exome sequencing (WES) report when performed in 2015. A review of CEP78-related literature unveiled that the initial report linking CEP78 to cone-rod dystrophy and hearing loss was published in September 2016. Any pathogenic variant found in CEP78 before 2016 would have been categorized as a "clearly disruptive variant in a gene of uncertain significance (GUS)" and might not have been reported in the WES report. It is important to acknowledge that our understanding of genotype-phenotype associations is undergoing rapid expansion. It is also crucial to recognize that repeat genetic testing may represent a fundamentally different approach, given the technological advancements not only in the coverage of the sequencing but also in the more comprehensive understanding of genotype-phenotype associations. This case series also enriches the existing CEP78 literature by providing phenotypic details of the youngest case of CEP78-associated retinopathy reported in the literature (Case 2), which expands our perspective on the natural history of disease in this disorder.
The invention concerns human PDZ protein 20 and polynucleotide encoding it. The invention also concerns the process of producing the polypeptide by recombinant DNA technique. The methods for treating many diseases e.g. malignant tumor, hemopathy, infection of HIV, immunological diseases and a variety of inflammation utilizing the polypeptide are disclosed. The invention discloses the antagonist against the polypeptide and therapeutics thereof. The invention also discloses the uses of the polynucleotide, which encodes human PDZ protein 20.
The aim of this study was to investigate the effect of rehabilitation of the dynamic muscle (RDM®) in back pain and postural balance of industrial operators. The sample consisted of industrial operators, individuals with low back pain, referred to the industry of Physical Therapy. After the screening criteria of inclusion and exclusion, 82 individuals were randomly selected and divided at random in: experimental group (GE, n = 41, age = 41 ± 4 years, body mass index (IMC) = 26.46 ± 3 , 25) and control group (CG, n = 42, age = 42 ± 5 years, IMC = 26.47 ± 3.34).

The GE was part of treatment with RDM. The CG was composed of individuals who did not participate in any physical therapy treatment during the search. The procedures used for evaluation were: back pain (Borg scale) and postural balance (pedana stabilometric and posturométrica). The process of intervention by the RDM had a duration of 20 minutes, frequency of twice a week and was extended for 12 weeks, and the systematic treatment performed on 4 occasions.
FIELD: medicine. ^ SUBSTANCE: method is proposed for preventing or slowing down development of atherosclerosis. It involves administration of molsidomine or a pharmaceutically acceptable salt thereof in the form of solid peroral composition with prolonged release of the active substance, effective for 24 hours and containing 14 to 24 mg of molsidomine. The composition is to be administered for at least 6 months. ^ EFFECT: method significantly decreases level of circulating ICAM-1s (an anti-inflammatory marker of endothelium dysfunction and therapeutic target at atherosclerosis pathological conditions) which play an important role in emergence and development of atherosclerosis. ^ 6 cl, 2 dwg, 2 tbl
The invention relates to organic honey vinegar and a preparation method thereof. The organic honey vinegar comprises honey, citric acid, acetic bacteria and a traditional Chinese medicine mixture. The traditional Chinese medicine mixture is prepared from, by weight part, 11-15 parts of lycium barbarum, 7-9 parts of concha haliotidis, 4-7 parts of the root of red-rooted salvia, 2-6 parts of albizia flowers and 4-9 parts of hawthorn fruits. All the ingredients are in compatibility, and the organic honey vinegar is rich and balanced in nutrition and unique in taste. The obtained product is sour, sweet, tasty and refreshing, can assist in digestion, has the functions of promoting appetite, relieving fatigue, enhancing immunity, preventing colds, softening blood vessels and reducing blood fat and blood pressure, and further has the functions of dispelling the effects of alcohol, protecting the liver, nourishing yang and assisting in sleep. The process is simple, the production cost is low, the made honey vinegar has diversified functions, the honey is matched with traditional Chinese medicines, and toxic and side effects are avoided.
This invention relates to a serum remnant-like lipoprotein concentration regulator. It contains triglycerides of medium-chain fatty acids. Wherein, at least 90 wt.% of the fatty acids as components of the triglycerides of medium-chain fatty acids are accounted for by C8 and C10 saturated fatty acids. The proportion of the C8 saturated fatty acid to the C10 saturated fatty acid is from 60/40 to 85/15 by weight. The C8 saturated fatty acid accounts for 60 to 85 wt.% of all the fatty acids bonded in the 2-positions in the triglycerides. The food for controlling the concentration of serum remnant-like lipoproteins contains the serum remnant-like lipoprotein concentration regulator. The medicine controls the concentration of serum remnant-like lipoproteins. The food for controlling the concentration of serum remnant-like lipoproteins does not necessitate a restricted diet. Consequently, it is free from the fear of side effects. Therefore, it can be used easily.
Secondary hyperparathyroidism (sHPT) is common in patients with chronic kidney disease (CKD), including those who are undergoing long-term dialysis treatments. sHPT is damaged for bone system, blood system, cardiovascular system, and so on. The treatment of the sHPT of CKD's patient includes dietary phosphate restriction, the use of medicines, and parathyroidectomy. In the mainland of China, there are not certain useful medicines to treat sHPT, including the derivatives of vitamin D, calcimimetic agent, non calcium aluminum phosphate binders. Furthermore, medical therapy is not always successful in achieving adequate control of sHPT. Oral medications have efficacy limitations as well as side-effects. Otherwise, surgery treatment can only be used for the patients with enlarged parathyroid gland(s). The patients may suffer from the injury of operation, hypoparathyroidism, or recurrence of hyperparathyroidism after parathyroidectomy.

Then ultrasonic ablation may become a valuable alternative treatment that help control sHPT in selected patients presenting with enlarged parathyroid gland(s) visible at ultrasonography,.
Control group consists of eligible HCPs who are randomized to control group(N=40) and would not receive any intervention. At the end of 3 month study period, control group participants would be eligible for TM training.