anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The presence of labetalol metabolites in the urine may result in falsely elevated levels of urinary catecholamines, metanephrine, normetanephrine and vanillylmandelic acid (VMA) when measured by fluorimetric or photometric methods. In screening patients suspected of having a pheochromocytoma and being treated with labetalol hydrochloride, a specific method, such as a high performance liquid chromatographic assay with solid phase extraction (e.g. J. Chromatogr 385:241, 1987) should be employed in determining levels of catecholamines. 

Labetalol hydrochloride has also been reported to produce a false-positive test for amphetamine when screening urine for the presence of drugs using the commercially available assay methods TOXI-Lab ® A (thin-layer chromatographic assay) and Emit-d.a.u. ® (radioenzymatic assay). When patients being treated with labetalol have a positive urine test for amphetamine using these techniques, confirmation should be made by using more specific methods, such as a gas chromatographic-mass spectrometer technique.
The present study was conducted with individuals aged 18 to 65 years with cervical disc herniation, who were suffered from neck pain lasting for at least 3 months, had a resting pain between 3-7 according to the "Visual Analog Scale" \[4\], and could follow the instructions of a physiotherapist. All individuals initially diagnosed as cervical disc lesion either one level or multilevel lesions, as diagnosed by the neurologist and confirmed by MRI imaging. The individuals with disk degeneration without cervical disk herniation, cervical stenosis and cervical spondylosis were excluded. In addition, individuals who had a history of spinal tumor or head trauma, had a spinal deformity or congenital malformation, had a cervical instability and cervical artery dysfunction, underwent any cervical surgery in the preceding 6 months, musculoskeletal disorders and neuromuscular diseases in the upper extremity and shoulders.
FIELD: veterinary science. SUBSTANCE: biopreparation has an association of synthrophic microorganisms (6 strains) taken at the definite titer and growth phase in liquid nutrient substrate. Substrate: corn extract or medium containing corn extract, potassium hydrogen phosphate, milled corn cobs and water. Biopreparation is used as an addition to poultry diet at amount 20 g/kg food. Biopreparation increases broiler gain weight, shows high biological activity, inhibits pathogen microorganisms development, activates digestion process in poultry, enhances biosynthesis of amino acids and vitamins, decreases food consumption per production unit. Preparation can be used for prophylaxis and treatment of gastroenteric sicknesses in poultry also. EFFECT: enhanced effectiveness of preparation. 1 tbl
Prior to starting the study, 10 hospitals will be made into 5 pairs. The paper versus smartphone intervention will be randomized to one member of each pair. The study arm will consist of a pre-interventional (6 weeks) followed by an interventional period (12 weeks); this arms will use paper-based decision support at the 5 hospitals designated.
This is a prospective single-arm multi-center clinical trial designed to evaluate the safety and efficacy of the Flexible Stenting Solutions Flext Stent® Femoropopliteal stenting system in subjects with lower limb peripheral arterial desease (PAD). Subjects targeted for enrollment must have a single de-novo lesion located in the superficial femoral artery and/or proximal popliteal artery with at \> 70% stenosis. Subjects must meet all enrollment criteria and provide written informed consent prior to participation in the study.
PURPOSE:To obtain an easily drinkable syrup having suppressed browning tendency of solution and formation of decomposition product, by adding a sugar alcohol to an aqueous solution of carbocysteine. CONSTITUTION:The objective syrup can be produced by adding a sugar alcohol (preferably D-sorbitol or xylitol) to an aqueous solution of carbocysteine and preferably adjusting the pH of the mixture to 6.0-7.5 with a pH-modifier. Carbocysteine is an air way mucus-conditioning and mucosa normalizing agent having excellent effect to the expectoration in various respiratory diseases. The syrup is further incorporated with a preservative (e.g. sorbic acid), a colorant (e.g. caramel), a flavor (e.g. fruit essence), a stabilizer (e.g. L-cysteine, EDTA, etc.), etc. The contents of carbocysteine, sugar alcohol and preservative in the syrup are preferably 2-10% (W/V), 10-70% and 0.05-2%, respectively.
In developed countries, there are various programs for pediatric oncology nurses to improve the quality of nursing care. Unfortunately, the inadequacy of these education programs in developing countries may prevent childhood cancer patients from receiving advanced care but may cause health inequalities. For this reason, it is very important to strengthen pediatric oncology nurses in terms of education and to develop platforms that will provide education continuity in low and middle-income countries. Today, one of the methods used to ensure the continuity and easy accessibility of education is digital education programs. Web-based education programs can increase nurses' knowledge and competence in related care issues. In studies, nurses state that planned educations were beneficial and increased their knowledge level. An accessible and sustainable web-based standard education program will enable nurses to become more competent in pediatric oncology and increase the quality of care. In Türkiye, which is a middle-income country, there is no standard curriculum for pediatric oncology nurses. Although pediatric oncology nursing is partially included in the oncology nursing certification program by the Oncology Nursing Association, we could say that it is insufficient to meet nurses' sustainability and educational needs. Therefore, there is a need for a digital website consisting of information and support modules to care for children with cancers for sustainable pediatric oncology nursing education in Türkiye.
Citri Sarcodactylis Fructus (CSF) is widely used as food raw material and traditional Chinese medicine. Fingerprints of different fractions of CSF were established for spectrum-effect relationship analysis, and the main compounds were identified by UHPLC Quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q/Orbitrap HRMS). The antitussive effect was evaluated using a classical mouse model of cough induced by ammonia water. One-way ANOVA was used to determine differences in efficacy. The potential active compounds were screened by spectrum-effect relationship with grey relational degree analysis (GRA), Pearson bivariate correlation analysis (Pearson's), and partial least squares analysis (PLS) analyses. Differential metabolites associated with cough in serum were screened and identified using orthogonal partial least squares-discriminant analysis, HMDB database, and UHPLC-Q/Orbitrap HRMS. Metabolic pathway analysis was performed using MetaboAnalyst 5.0. Results indicate that 70 % ethanol elution fraction (70 % EF) is the major active fraction, and 8 components were identified to possess antitussive effects. Metabolomic analysis showed that 19 metabolites are potential biomarkers related to cough, and 70 % EF can remarkable restore 13 of them to normal levels (P < 0.05). These biomarkers are mainly involved in glycerophospholipid metabolism and sphingolipid metabolism. This study aims to reveal the main pharmacodynamic active sites and potential active ingredients of CSF's antitussive effect. In addition, metabolomics was used to preliminarily elucidate the in-vivo regulatory mechanism of the antitussive effect of the 70 % EF of CSF.
Participants will complete 1.5 hr group sessions once per week for 12 weeks of Skills Training in Affective and Interpersonal Regulation (STAIR). Participants will complete self-report measures pre, post, and at one month intervals.
Producing a dairy product on a production line comprising continuously injecting a molten sterol or stanol ester into a milk-based composition containing milk protein but no emulsifier and then homogenizing the mixture,is new. During injection, the temperature (T 2) of the composition is at least equal to the temperature (T 1) of the molten sterol or stanol ester. Independent claims are also included for: (1) product produced as above; (2) apparatus for carrying out the above process, comprising means for maintaining the ester at T 1, e.g. an insulated or thermostatted tank; means for passing the ester to the feed system of the production line while maintaining the ester at T 1, e.g. an insulated pipe; and means for introduing the ester at T 1 into the production line, e.g. a pump.
Adaptive platform trials (APTs) offer a promising alternative to traditional randomised controlled trials for evaluating treatments for paediatric sepsis. Randomised controlled trials, despite being the gold standard for establishing causality between interventions and outcomes, make many assumptions about disease prevalence, severity and intervention effects, which are often incorrect. As a result, the evidence for most treatments for paediatric sepsis are based on low-quality evidence. APTs use accrued data rather than assumptions to power trial adaptations. They can assess multiple treatments simultaneously with shared research infrastructure. As such, APTs offer a more efficient, flexible and more effective way to identify optimal treatments. The proposed Paediatric Adaptive Sepsis Platform Trial, leveraging the Paediatric Research in Emergency Departments International Collaborative network's infrastructure, will evaluate resuscitation fluids, vasoactive medications, corticosteroids and antimicrobials. This trial has the potential to substantially impact clinical practice and reduce global sepsis mortality in children.
The aim of this study is to investigate the therapeutic value of resistant training (RT) in improving sarcopenia in heart failure patients. To better achieve such therapeutic effects, the design of RT program also needs to comply with the exercise guideline with emphasis placed on increasing the skeletal muscle mass (i.e., the key pathological factor of sarcopenia). Addressing these research agenda is crucial to inform the development of evidence-based practice to tackle the prognostic impact of sarcopenia among HF patients. This is a sequential mixed method study including a pilot RCT to evaluate the preliminary effect of a 14-week elastic band-progressive resistance training (EB-PRT) and a subsequent qualitative study to explore the subjects' engagement experience. The total study period last for 40 weeks. The sample size is 62 participants. It is a single-blinded study. The research assistants for data collection will be blinded.

For intervention group, EB-PRT is implemented during week 1-14. A purposive sample of 12 participants invited for qualitative interview during 21st -22nd week. There are 2 post-test evaluations at 14th week (T1) and 26th week (T2). After the second evaluation at week 26, the group will receive usual care with routine follow-up. For the qualitative study on, a subsample of 12 participants in intervention group will be invited to explore their experience and perception at about 21st-22th week. The interview will be semi-structured and taken about 30-40 minutes at participants' home. The control group will receive usual care including the medical care offered by the specialist out-patient clinic during 1-26 week. There are 2 post-test evaluations at 14th week (T1) and 26th week (T2). From week 27 to week 40, this wait-list control group will receive the same EB-PRT as the intervention group.
The invention belongs to the technical field of medicine, and provides a Tibetan pharmaceutical, lamiophlomis rotata total flavone extractive as well as an extracting method and the application thereof. The method uses Tibetan pharmaceutical lamiophlomis rotata as raw material, uses ethanol prepared by alkalescence solution with different pH values as solvent, and adopts a backflow method for extracting. After two steps of decontamination and the separation and enrichment of macropore resin, the total flavone extractive with the purity being 50 to 95 percent can be obtained from extracting solution. In the process of separation and enrichment, after the two steps of decontamination and the separation and enrichment of macropore resin, a sample with high purity can be obtained and the purity of the total flavone in the sample can be 95 percent at most, wherein, the percentage is higher than the number reported in documents. The invention also provides the application of the total flavone as pain killer medicine and stanch medicine. The paper optimizes and improves the extracting method so as to increase the transfer rate of effective ingredient, improve the utilization rate of medicinal materials and save a great amount of cost effectively, thus having high economical benefit.
Morbilliviruses are members of the family Paramyxoviridae and are known for their ability to cause systemic disease in a variety of mammalian hosts. The prototypic morbillivirus, measles virus (MeV), infects humans and still causes morbidity and mortality in unvaccinated children and young adults. Experimental infection studies in non-human primates have contributed to the understanding of measles pathogenesis. However, ethical restrictions call for the development of new animal models. Canine distemper virus (CDV) infects a wide range of animals, including ferrets, and its pathogenesis shares many features with measles. However, wild-type CDV infection is almost always lethal, while MeV infection is usually self-limiting. Here, we made five recombinant CDVs, predicted to be attenuated, and compared their pathogenesis to the non-attenuated recombinant CDV in a ferret model. Three viruses were insufficiently attenuated based on clinical signs, fatality, and systemic infection, while one virus was too attenuated. The last candidate virus caused a self-limiting infection associated with transient viremia and viral dissemination to all lymphoid tissues, was shed transiently from the upper respiratory tract, and did not result in acute neurological signs. Additionally, an in-depth phenotyping of the infected white blood cells showed lower infection percentages in all lymphocyte subsets when compared to the non-attenuated CDV. In conclusion, infection models using this candidate virus mimic measles and can be used to study pathogenesis-related questions and to test interventions for morbilliviruses in a natural host species.IMPORTANCEMorbilliviruses are transmitted via the respiratory route but cause systemic disease. The viruses use two cellular receptors to infect myeloid, lymphoid, and epithelial cells. Measles virus (MeV) remains an important cause of morbidity and mortality in humans, requiring animal models to study pathogenesis or intervention strategies. Experimental MeV infections in non-human primates are restricted by ethical and practical constraints, and animal morbillivirus infections in natural host species have been considered as alternatives. Inoculation of ferrets with wild-type canine distemper virus (CDV) has been used for this purpose, but in most cases, the virus overwhelms the immune system and causes highly lethal disease. Introduction of an additional transcription unit and an additional attenuating point mutation in the polymerase yielded a candidate virus that caused self-limiting disease with transient viremia and virus shedding. This rationally attenuated CDV strain can be used for experimental morbillivirus infections in ferrets that reflect measles in humans.
The study involves 5 study days. The duration of the first 4 study days is approximately 6.5 hours per day and the duration of the 5th study day is approximately 8 hours. On each of the first 4 study days the effect a casein protein meal with or without leucine and carbohydrates will be examined. On the fifth study day the effect of 4 different levels of casein protein and carbohydrate intake by sip feeding (every 20 minutes) is examined.

Also, subjects will receive a mixture of amino acids (little parts of protein) which are a little bit heavier than normal, called stable isotopes. This is the so-called stable isotope method to investigate protein behavior in the body (protein kinetics). Altogether about 75 ml of blood will be drawn per study day to assess outcome measures.
A double-blinded, randomised, prospective controlled trial was conducted at US Neuropathy Centers in Marietta, GA, under the approval of the Kennesaw State University Institutional Review Board. Patients with weak dorsiflexion of the ankle or a drop foot were recruited from the existing clinical practice at US Neuropathy Centers. Cohort inclusion criteria also included a stable medical and medication status, ages 18-85, speaking English as the primary language, and ambulatory. Walking aids or ankle-foot orthosis were permitted.. Based on the inclusion criteria, only 20 patients were enrolled. Patients were recruited over a period of 1 year and two months from January 2021 to March 2022 with no requirement for follow-up. The enrolment phase was concluded as the study was originally designed as a pilot investigation, with recruitment limited to a single, small medical practice. A total of 20 patients were successfully enrolled within this setting.Participants were randomised by the throw of dice to injection of 0.3 cc of Papaverine HCl 10 mg/mL or 0.3 cc of 1% Lidocaine HCl adjacent to CFN in a room separate from patient room. Injection solutions were prepared by non-blinded assistants and were visually indistinguishable. Patients and physicians are blinded to drugs received. Motor strength of the Extensor Hallucis Longus (EHL), Tibialis Anterior (TA), and Extensor Digitorum Longus (EDL) muscles were tested. Strength was rated according to the Medical Research Council Manual Muscle Testing scale 0-5. The CFN at the fibular neck was identified under high-resolution ultrasound imaging. The injection site was prepared with alcohol, and ethyl chloride was used to anaesthetise the skin. A 30-gauge 1-inch needle was inserted adjacent to, but not within, the CFN. The infiltrate was delivered at the level of the fibular neck just proximal to where the CPN coursed beneath the deep fascia of the peroneus longus. This was immediately adjacent to the first known anatomical site of compression of the CPN. 0.3cc of the drug was delivered.

The investigator then waited approximately five minutes and re-tested motor strength of the Extensor Hallucis Longus (EHL), Tibialis Anterior (TA), and Extensor Digitorum Longus (EDL) muscles manually.
The invention discloses a technical method for treating a liver-gallbladder syndrome of fish by using a Chinese herbal medicine. The Chinese herbal medicine comprises 25% of purslane, 25% of isatis root, 15% of dyer woad leaf, 10% of Junlian and 25% of Chinese rhubarb-phellodendron-baical skullcap root powder (wherein Chinese rhubarb accounts for 50%, phellodendron accounts for 30% and baical skullcap root accounts for 20%). The Chinese herbal medicine is prepared by crushing, mixing and stirring a plurality of medicinal herbs. 50 to 100 g of the Chinese herbal medicine is added into each kg of a feed, and the feed is continuously applied for 10 d. The Chinese herbal medicine has been used for years, presents a good effect and especially exerts a substantial effect on snakeheaded fish, grass carp, carp and the like. According to the characteristics of the liver-gallbladder syndrome of fish, medicinal herbs capable of eliminating toxins, protecting and coursing the liver and rectifying qi are used for preparation of the Chinese herbal medicine which is used to treat the liver-gallbladder syndrome. The Chinese herbal medicine has the characteristics of anti-fatty liver performance, detoxification, anti-hepatic injury performance, capacity of promoting regeneration and functional recovery of hepatocytes and inhibiting liver cirrhosis, etc. The method is simple and is convenient to operate; the medicinal herbs are easily purchasable and cheap; the Chinese herbal medicine has a high cure rate, no toxic and side effects, no drug residue and no harm to a water body.
PROBLEM TO BE SOLVED: To provide a new cosmetic sheet by activating the characteristics of a silicon adhesive capable of long time pasting.SOLUTION: Provided is a silicon adhesive sheet using a silicon adhesive cross-linked and also having a probe tack value of 0.3 N/10 mmφ or higher. The silicon adhesive sheet preferably has a thickness of 20 μm to 1 mm. The silicon adhesive is cross-linked so as to control the probe tack value to 0.3N/10 mmφ or more. The fracture elongation degree of the cosmetic sheet is preferably 50% or more. The silicon adhesive can include a cosmetic valuable component therein. Further, the silicon adhesive sheet preferably uses a polyurethane sheet as a supporting body.
The present invention provides novel compounds ( e.g. , compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be a  Candida  species,  Aspergillus  species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds.
Liquid biopsy will be performed at the first visit using InVisionFirst®. Treatment will be determined by (i) genomic characterization in plasma for patients with druggable alteration in first-line, (ii) after pathology results (including assessment of PD-L1 level of expression by immunohistochemistry) for patients with an informative molecular characterization on plasma and no druggable alteration in first-line and (iii) after pathology results and tissue molecular characterization for the remaining patients.
The FICB is a regional block that anesthetizes the femoral, obturator, and lateral femoral cutaneous nerves around the hip joint. There have been numerous study assessing it's ability to control pain in the pre and post operative period in patients with hip fractures. However, there is a limited amount of literature on its efficacy after total hip arthroplasty, and no data when a posterior surgical approach to the hip was utilized. Because regional blocks have been shown to decrease pain post operatively after total knee arthroplasty, we hypothesize that the FICB will decrease pain and narcotic use in patients after total hip arthroplasty. This study will aim to recruit 120 patients that will be randomized to receive a FICB or placebo in the recovery room within 30 minutes of leaving the OR. Once the intervention is complete we will collect data on the patients' pain levels, morphine equivalents of narcotic that they used, and how well they worked with physical therapy during their inpatient stay.