anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants randomized to this arm will receive the Arm 1 scorecard plus dynamic social norms messaging (noting the proportion of Humana members improving their medication refill scores). Two messages will be sent during the intervention: The first message will contain the baseline refill score. The second message will note any changes in the refill score.
Intense, recurrent abdominal (visceral) pain is a predominant symptom of irritable bowel syndrome (IBS), a functional gut disorder that typically manifests in the early adult years. IBS is common with prevalence reaching over 20% in some regions of the world, and affects more women than men. While women report more severe IBS-related pain, both younger men and women report more severe pain compared to older adult cohorts. Direct costs of care and lost productivity in the U.S. exceed $21 billion annually, and individuals with IBS utilize more healthcare services than the general population, including outpatient visits, diagnostic testing and over-the-counter and prescription medications. Individuals with IBS report that pain is the most distressing symptom and has the greatest impact on quality of life, however, current approaches to improve self- management of IBS-related pain do not target individual, context-specific factors of pain. Therefore, individuals with IBS-related pain often endure a long and frustrating course of learning how to manage pain on their own accord. The proposed pilot project was developed based on this common situation and will provide feasibility data about the influence of providing a personalized pain SM intervention to individuals with IBS-related pain. IBS-related pain is associated with sensitization of the central nervous system, and approximately half of all patients with IBS have visceral hypersensitivity. These alterations in pain processing escalate pain perception, and can increase vulnerability to other co-morbid pain disorders which individuals with IBS frequently suffer. Pain sensitization is influenced by pain-sensitivity genes and, specific to IBS-related pain, the gut microbiome. Therefore, as contextual factors of pain associated with IBS, the investigators will measure peripheral and central sensitivity, single-nucleotide polymorphisms (SNPs) of candidate pain-sensitivity genes and the gut microbiome. The SM intervention was designed to provide factual information about IBS pain, triggers of pain and pain SM skills. The experimental group will receive one-on-one consultation tailored around the individual's assessment results of peripheral and central pain sensitivity as measured by quantitative sensory testing (QST) and targeted toward increasing pain self-efficacy and self-regulation skills and abilities. The proposed pilot project will provide foundational information about the contextual factors of IBS pain (pain catastrophizing, perceived stress, reactivity pain sensitivity, genetic and microbiome) on pain SM process and outcomes. In addition, the investigators will gain insight on the potential impact of the personalized IBS-pain SM approach on pain SM behaviors and health outcomes.
BACKGROUND AND AIMS: We aimed to investigate the relationship between triglyceride glucose (TyG) index and intracoronary thrombus burden in patients with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).
METHODS AND RESULTS: A total of 468 consecutive patients who were admitted with STEMI and underwent primary PCI were included in the study. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. According to the angiographic reclassified thrombolysis in myocardial infarction (TIMI) thrombus grade, patients were divided into two groups as small thrombus burden (STB) with TIMI thrombus grade 0-3, and large thrombus burden (LTB) with TIMI thrombus grade 4-5. TyG index was significantly higher in the LTB group than in the STB group (9.11 ± 0.86 vs 8.89 ± 0.62; p = 0.002). In multivariate analysis, TyG index was found to be an independent predictor of LTB in STEMI patients who underwent primary PCI [OR (95 % CI): 1.470 (1.090-1.982), p = 0.012]. The area under the curve (AUC) of TyG index predicting LTB was 0.568 (95 % CI 0.506-0.631; p = 0.023), with the best cut-off value of 8.87. In the classification according to TyG index cut-off value, the frequency of LTB was found to be significantly higher in the high TyG index group than in the low TyG index group (33.6 % vs 21.2 %; p = 0.003).
CONCLUSION: TyG index, a valid surrogate marker of insulin resistance, is an independent predictor of LTB in STEMI patients who underwent primary PCI and can be used as an indicator of increased intracoronary thrombus burden.
PROBLEM TO BE SOLVED: To successfully carry out coagulation of even easily hydrolyzable products by water. SOLUTION: Together with one of water-soluble powder binders, a powder of a slightly soluble substance is led to a steam atmosphere in a temperature range from 85 deg.C to 105 deg.C and free falls without being affected by compressive force. In this method, the residence time in the steam atmosphere is set to be about 0.5-10 seconds. Then, the produced coagulated substance is dried while being free-falling in a manner that solid-state bridges are formed from liquid- state bridges of the binder formed at the contacting points of main particles. Final drying treatment of the substance is carried out in a united type fluidizing bed drier installed in the next until the water content is lowered to 0.5wt.% or lower.  The method is carried out in a steam jet coagulating apparatus and in this method, by utilizing steam jet nozzles 5, 6, steam is jetted to collide against a free-falling product curtain of a powder mixture to be coagulated. A fluidizing bed drier 2 is so joined to a lower part of the coagulating apparatus 1 as to make the coagulated particles 4 directly fall in the fluidizing bed.
Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually associated with adaptation to stress conditions. Chromosomal duplication stability is a tradeoff between the fitness cost of having unbalanced gene copies and the potential fitness gained from increased dosage of specific advantageous genes. Trypanosomatids, a family of protozoans that include species that cause neglected tropical diseases, are a relevant group to study aneuploidies. Their life cycle has several stressors that could select for different patterns of chromosomal duplications and/or losses, and their nearly universal use of polycistronic transcription increases their reliance on gene expansion/contraction, as well as post-transcriptional control as mechanisms for gene expression regulation. By evaluating the data from 866 isolates covering seven trypanosomatid genera, we have revealed that aneuploidy tolerance is an ancestral characteristic of trypanosomatids but has a reduced occurrence in a specific monophyletic clade that has undergone large genomic reorganization and chromosomal fusions. We have also identified an ancient chromosomal duplication that was maintained across these parasite's speciation, named collectively as the trypanosomatid ancestral supernumerary chromosome (TASC). TASC has most genes in the same coding strand, is expressed as a disomic chromosome (even having four copies), and has increased potential for functional variation, but it purges highly deleterious mutations more efficiently than other chromosomes. The evidence of stringent control over gene expression in this chromosome suggests that these parasites have adapted to mitigate the fitness cost associated with this ancient chromosomal duplication.
NEW MATERIAL:A compound expressed by the formula (n is 1 or 2). EXAMPLE:Ethyl beta-sulfo-gamma-trimethylammoniobutyrate. USE:A remedy for cardiopathy and intermediate raw material for medicines. PREPARATION:Sodium acid sulfite is added to crotonobetaine and reacted therewith at 20-100 deg.C, prererably 40-70 deg.C and 3-10pH for 6-12hr, and the resultant product is then treated with a cation exchange resin, e.g. Amberlite IR-120. A lower alcohol, e.g. methanol, is added to esterify the treated product, preferably in the presence of an acid catalyst, e.g. sulfuric acid, to give the aimed compound expressed by the formula.
HYOSCYAMINE SULFATE is a parasympatholytic which relaxes smooth muscles and thus produces an antispasmodic effect. It is well absorbed from the gastrointestinal tract and is rapidly distributed throughout the body tissues. Most is excreted in the urine within 12 hours, 13% to 50% being unchanged. Its biotransformation is hepatic. Its protein binding is moderate.

METHENAMINE degrades in an acidic urine environment releasing formaldehyde which provides bactericidal or bacteriostatic action. It is well absorbed from the gastrointestinal tract. 70%-90% reaches the urine unchanged at which point it is hydrolyzed if the urine is acidic. Within 24 hours it is almost completely (90%) excreted; of this at a pH of 5, approximately 20% is formaldehyde. Protein binding – some formaldehyde is bound to substances in the urine and surrounding tissues. Methenamine is freely distributed to body tissue and fluids but is not clinically significant as it does not hydrolyze at pH greater than 6.8.

METHYLENE BLUE possesses weak antiseptic properties. It is well absorbed by the gastrointestinal tract and rapidly reduced to leukomethylene blue which is stabilized in some combination form in the urine. 75% is excreted unchanged.

PHENYL SALICYLATE releases salicylate, a mild analgesic for pain.

SODIUM PHOSPHATE MONOBASIC an acidifier, helps to maintain an acid pH in the urine necessary for the degradation of methenamine.
Tetraploid oysters are artificially produced oysters that do not exist in nature. The successful breeding of 100% triploid oysters resolved the difficulties of traditional drug-induced triploids, such as the presence of drug residues and a low triploid induction rate. However, little is known concerning the biochemical composition and nutrient contents of such tetraploids. Therefore, we investigated compositional differences among diploid, triploid, and tetraploid Crassostrea gigas as well as between males and females of diploids and tetraploids. The findings indicated that glycogen, EPA, ∑PUFA, and omega-3 contents were significantly higher in triploid oysters than in diploids or tetraploids; tetraploid oysters had a significantly higher protein content, C14:0, essential amino acid, and flavor-presenting amino acid contents than diploids or triploids. For both diploid and tetraploids, females had significantly higher levels of glutamate, methionine, and phenylalanine than males but lower levels of glycine and alanine. In addition, female oysters had significantly more EPA, DHA, omega-3, and total fatty acids, a result that may be due to the fact that gonadal development in male oysters requires more energy to sustain growth, consumes greater amounts of nutrients, and accumulates more proteins. With these results, important information is provided on the production of C. gigas, as well as on the basis and backing for the genetic breeding of oysters.
Ketoconazole and quinidine, inhibitors of CYP450, 3A4 and 2D6, respectively, inhibit donepezil metabolism in vitro. Whether there is a clinical effect of quinidine is not known. In a 7-day crossover study in 18 healthy volunteers, ketoconazole (200 mg q.d.) increased mean donepezil (5 mg q.d.) concentrations (AUC0-24 and Cmax) by 36%. The clinical relevance of this increase in concentration is unknown.

A small effect of CYP2D6 inhibitors was identified in a population pharmacokinetic analysis of plasma donepezil concentrations measured in patients with Alzheimer's disease. Donepezil clearance was reduced by approximately 17% in patients taking 10 or 23 mg in combination with a known CYP2D6 inhibitor. This result is consistent with the conclusion that CYP2D6 is a minor metabolic pathway of donepezil.

Inducers of CYP 2D6 and CYP 3A4 (e.g., phenytoin, carbamazepine, dexamethasone, rifampin, and phenobarbital) could increase the rate of elimination of ARICEPT.

Formal pharmacokinetic studies demonstrated that the metabolism of ARICEPT is not significantly affected by concurrent administration of digoxin or cimetidine.
All radiographic assessments, including cephalometric, pharyngeal airway and craniocervical measurements were performed by the same researcher and she was blind to all the treatment details, orthodontic records, and information of the subjects to prevent bias. Lateral cephalometric radiographs were taken digitally with an X-ray unit (OP300; Instrumentarium Dental, Tuusula, Finland) according to the manufacturer and same technician. Subjects were positioned at the natural head position, teeth in centric occlusion, and lightly closed lips for lateral cephalometric radiographs. Skeletal development of individuals was evaluated using cervical vertebra maturation method (Ref: Bacetti T., An Improved Version of the Cervical Vertebral Maturation (CVM) Method for the Assessment of Mandibular Growth. Angle Orthod.). The skeletal development of individuals was evaluated using the cervical vertebra maturation method and it was determined that all patients were in the prepubertal stage (CS1-CS3). (Ref: Cevidanes L., Comparison of two protocols for maxillary protraction: bone anchors versus face mask with rapid maxillary expansion. Angle Orthod.)
The nonsteroid gestagens can be used individually or in combination with estrogens in contraceptive preparations, in the treatment of endometriosis, as well as of gynaecological distrurbances. The compounds can find also application in the treatment of premenstrual complaints and in substitution treatment. Their androgenous activity makes them suitable for controlling the male fertility, in male hormonosubstituting therapy (HRT) and in the treatment of andrological syndromes. They have the general formula where R1 & R2 are the same or different and mean hydrogen atom, C1-5 alkyl group or halogen atom or together with C-atom of the chain form a total of 3-7 member ring; R3 means C1-5 alkyl group or completely or partially fluorized C1-5 alkyl group; A means optionally substituted mono- or bicyclic aromatic ring, ester group -COOR4, alkenyl group -CR5=CR6R7, alkynyl group -C CR5 or partially or completely fluorized C1-5 alkyl group. B is carbonyl or CH2 group and Ar is a ring system selected from the following group of general partial formulae in case that B in the general formula I means CH2 group, Ar can mean phenyl residue with general partial formula The new compounds have very high affinity to the gestagen receptor. 33 claims
The invention relates to a medicine for treating whelk by the use of Chinese herbal medicines as raw materials and a production method thereof. The present method for treating whelk is oral administration of antibiotics, which will imperceptibly increase liver and kidney burden. Photodynamic therapy requires high treatment cost such that consumers can't afford. Contraceptive drugs have side-effect. Squeezing out acne directly for will lead to scars and aggravate infection. According to whelk pathogenesis, the medicine provided by the invention is prepared by immersing dandelion, barbados aloe and peach blossom in 27-42 weight parts of medical alcohol with the concentration of 50-95%. By the utilization of traditional Chinese medicines, the medicine provided by the invention treats both principal and secondary aspect of whelk. By the adoption of the medicine prepared by the production method, the cure rate of the medicine reaches 100% with no relapse.
As the influence and risk of infectious diseases increase, efforts are being made to predict the number of confirmed infectious disease patients, but research involving the qualitative opinions of social media users is scarce. However, social data can change the psychology and behaviors of crowds through information dissemination, which can affect the spread of infectious diseases. Existing studies have used the number of confirmed cases and spatial data to predict the number of confirmed cases of infectious diseases. However, studies using opinions from social data that affect changes in human behavior in relation to the spread of infectious diseases are inadequate. Therefore, herein, we propose a new approach for sentiment analysis of social data by using opinion mining and to predict the number of confirmed cases of infectious diseases by using machine learning techniques. To build a sentiment dictionary specialized for predicting infectious diseases, we used Word2Vec to expand the existing sentiment dictionary and calculate the daily sentiment polarity by dividing it into positive and negative polarities from collected social data. Thereafter, we developed an algorithm to predict the number of confirmed infectious patients by using both positive and negative polarities with DNN, LSTM and GRU. The method proposed herein showed that the prediction results of the number of confirmed cases obtained using opinion mining were 1.12% and 3% better than those obtained without using opinion mining in LSTM and GRU model, and it is expected that social data will be used from a qualitative perspective for predicting the number of confirmed cases of infectious diseases.
Grapefruit Juice: Coadministration of nifedipine with grapefruit juice resulted in approximately a doubling in nifedipine AUC and C max with no change in half-life. The increased plasma concentrations most likely result from inhibition of CYP 3A4 related first-pass metabolism. Avoid ingestion of grapefruit and grapefruit juice should be avoided while taking nifedipine. 

Carcinogenesis, Mutagenesis, Impairment of Fertility: Nifedipine was administered orally to rats for two years and was not shown to be carcinogenic. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 5 times the maximum recommended human dose. There is a literature report of reversible reduction in the ability of human sperm obtained from a limited number of infertile men taking recommended doses of nifedipine to bind to and fertilize an ovum in vitro. In vivo mutagenicity studies were negative. 

Pregnancy: Pregnancy Category C: Nifedipine has been shown to produce teratogenic findings in rats and rabbits, including digital anomalies similar to those reported for phenytoin. Digital anomalies have been reported to occur with other members of the dihydropyridine class and are possibly a result of compromised uterine blood flow. Nifedipine administration was associated with a variety of embryotoxic, placentotoxic, and fetotoxic effects, including stunted fetuses (rats, mice, rabbits), rib deformities (mice), cleft palate (mice), small placentas and underdeveloped chorionic villi (monkeys), embryonic and fetal deaths (rats, mice, rabbits), and prolonged pregnancy/decreased neonatal survival (rats; not evaluated in other species). On a mg/kg basis, all of the doses associated with the teratogenic embryotoxic or fetotoxic effects in animals were higher (5 to 50 times) than the maximum recommended human dose of 120 mg/day. On a mg/m 2 basis, some doses were higher and some were lower than the maximum recommended human dose, but all are within an order of magnitude of it. The doses associated with placentotoxic effects in monkeys were equivalent to or lower than the maximum recommended human dose on a mg/m 2 basis. 

There are no adequate and well-controlled studies in pregnant women. Nifedipine extended-release tablets should be used during pregnancy only if the potential benefit justifies the potential risk.

Lactation: Nifedipine is transferred through breast milk. Nifedipine extended-release tablets should be used during breastfeeding only if the potential benefit justifies the potential risk. 

Pediatric Use: Safety and effectiveness in pediatric patients have not been established. 

Geriatric Use: Age appears to have a significant effect on the pharmacokinetics of nifedipine. The clearance is decreased resulting in a higher AUC in the elderly. These changes are not due to changes in renal function (see CLINICALPHARMACOLOGY, Pharmacokinetics).
NEW MATERIAL:The compound of formula I (R1-R3 are H, CH3 or halogen; R4 is H or two R4s together forming a bond between C atoms; m is 0 or 1; n is 0-2; Y is H or phenyl which may be substituted with <=4C alkyl, OH, OCH3, halogen, oxycarbonylmethoxy or ethoxycarbonylmethoxy). EXAMPLE:1-Benzyl-2-(2-benzoylethen-1-yl)imidazole. USE:A medicine. An antiulcer agent. PREPARATION:A compound of formula I wherein two R4s together form a bond between C atoms can be produced by reacting a compound of formula II with a compound of formula III in a solvent such as ethanol in the presence of sodium ethoxide, etc. The product can be converted into another compound of formula I wherein each R4 is H by the catalytic reduction in a solvent in the presence of a catalyst such as Pd/C.
In clinical trials and in postmarketing experience, adverse reactions of deliberate or accidental overdosage with oral aripiprazole have been reported worldwide. These include overdoses with oral aripiprazole alone and in combination with other substances. No fatality was reported with aripiprazole alone. The largest known dose with a known outcome involved acute ingestion of 1260 mg of oral aripiprazole (42 times the maximum recommended daily dose) by a patient who fully recovered. Deliberate or accidental overdosage was also reported in children (age 12 and younger) involving oral aripiprazole ingestions up to 195 mg with no fatalities.  
Common adverse reactions (reported in at least 5% of all overdose cases) reported with oral aripiprazole overdosage (alone or in combination with other substances) include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed in one or more patients with aripiprazole overdoses (alone or with other substances) include acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia.
A computer-implemented method is for classifying a region of interest in a medical image data set depicting a body part of a patient. The region of interest contains an object of potential pathological relevance. In an embodiment, the method includes a plurality of steps. One step is directed to generate a plurality of different representations of the region of interest. Another step is directed to determine, for each of the representations, a classification to generate a corresponding plurality of classifications. Thereby, each classification indicates a pathological relevance of the object in the respective representation. Yet, a further step is directed to calculate an ensemble classification for the region of interest based on the plurality of classifications.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in surgery and chemotherapy of brain neoplasms. The method is implemented as follows: the tumour extraction is followed by intraoperative intake of the perifocal brain tissue in amount 1 cm3. Then perifocal tissue is incubated with carboplatin 0.2 mg added in vitro at temperature 38C for 30 minutes and placed in a container made of a haemostatic sponge. Haemostasis is performed, the container is arranged in a bed of the extracted tumour with taking liquor on 2nd, 4th, 7th, 10th, 12th days to detect the chemopreparation in all portions. ^ EFFECT: use of the invention allows intensifying the antineoplastic effect, prolonging the recurrence-free period due to action of carboplatin incubated with the perifocal tissue. ^ 1 ex