anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The AcNK technology has successfully achieved the direct, covalent, and directional conjugation of intact antibodies which includes the Fc domain to the surface of NK cells via a one-step enzymatic reaction. This novel approach yields a non-genetically modified NK cell that is conjugated with dual-targeting antibodies, referred to as AcNK. Specifically, AcNK-Sup003 cells are cryopreserved NK cells that have been conjugated with bispecific antibodies target both CD20 and CD19. This clinical trial is an open-label, nonrandomized, investigator-initiated clinical trial to evaluate the safety, tolerability, pharmacokinetics, and efficacy of AcNK-Sup003 cell injection in patients with elapsed or refractory B-cell non-Hodgkin's lymphoma. The treatment cycle in this study is 28 days. A modified "3+3" design principle combined with accelerated titration is used, with three dose cohorts and one alternative dose cohort, each including 1 to 6 subjects (adjustments may be made based on the safety and efficacy results of enrolled subjects). The dose levels are: Dose Level 1: 3×10\^8 AcNK-Sup003 cells, Dose Level 2: 1×10\^9 AcNK-Sup003 cells, Dose Level 3: 3×10\^9 AcNK-Sup003 cells, Dose Level 4 (alternative dose): 9×10\^9 AcNK-Sup003 cells (with a flexibility range of ±20%). Treatments are administered up to three times from Day 0 to Day 14 of each cycle (recommended D0/D7/D14, the frequency of infusion per cycle may be adjusted by the investigator based on obtained PK data and the subject's actual situation).
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to technology of medicinal preparations preparing. Invention proposes the human placenta allogenic preparation showing an anti-inflammatory, reparative, antibacterial and wound-healing effect that contains human placenta high-molecular proteins and glucoseaminoglycans (molecular mass is above 10 000 Da) and also glycerol and purified water at the following ratio of components, wt. -%: placenta proteins (molecular mass is above 10 000 Da) 5.0-5.5; glucoseamino-glycans (molecular mass is above 10 000 Da) 1.0-1.5; glycerol 50.0-55.0, and purified water - the rest. Method of preparing the human placenta allogenic preparation involves extraction of biomaterial with 40% alcohol for 15 min followed by homogenization and extraction with purified water (as measured 1:1), centrifugation at 3 000 rev/min and separation of supernatant. The latter is purified and concentrated on ultrafiltering unit working as dynamic filter and glycerol and purified water are added. EFFECT: simplified method, improved quality of the preparation. 2 cl, 12 tbl, 4 ex
Eligible women with Fibromyalgia (FM) will be enrolled into a 10-week drug trial. During the first two weeks, a baseline phase will be used to collect data on immune function and symptoms. LDN will be administered for 8 weeks. Although there is no placebo arm built-in, participants will be advised that they may receive a placebo during the trial. Participants will provide twice daily symptom reports using an android tablet device and Dooblo SurveyToGo survey software. Participants will also provide a blood sample twice every week for the duration of the study. Plasma inflammatory markers will be tested using a luminex based 63-plex inflammatory assay panel.

The primary aim of the study is to test if 8 weeks of LDN administration is associated with a reduction in pro-inflammatory markers in plasma in women with FM.
Dissatisfaction with the genital image has been receiving more attention in recent years and is influenced by mediation and the methods of waxing modernity. In the face of this, the number of women in search for aesthetic female genital surgeries. Since the year 2015, the implementation of the Labiaplasty surgery had a growth of 45% worldwide. Brazil is a leader in the procedure, with a total of 23,155 procedures in the year 2016 (ISAPS DATA). However, the Most genital surgical cases are performed unnecessarily, without long-term term, according to a conflict of interest arising from financial gain, generating ethical complications The search for aesthetic non-invasive genital treatments, in its majority, is related to sagging big lips and genital hyperchromia. In the literature, the non-invasive therapeutic resource and with fewer adverse effects described for aesthetics of the genital region is the use of the radiofrequency apparatus ablative, considered to be a safe and effective technique for flaccidity of the cutaneous tissue. It is not described in the literature treatments used for genital hyperchromia, however, several formulations for clearings using Kojic acid and Niacinamide, already described as effective for other regions, are available for marketing primarily for genital year whitening.

Minimally invasive technique, consists of the application of a roller surrounded by small and thin needles that pierce the skin and generate a mechanical stimulus with no ablative effect on the skin.
The invention discloses marine biological function cosmetics for minimizing pores. The marine biological function cosmetics for minimizing the pores are prepared by mixing and homogenizing main active ingredients and a cosmetic substrate, wherein the main active ingredients comprise marine shellfish active peptide, marine collagen protein peptide, seaweed polysaccharide and fish oil. Hyaluronic acid and vitamin C (Vc) are added, so that the effect is more obvious. The marine biological function cosmetics for minimizing the pores solve the problems that the conventional cosmetics for minimizing the pores have high irritation and short action time, the marine shellfish active peptide is not applied to cosmetics, the marine biological active substances are not applied to the cosmetics for minimizing the pores and the like. The marine biological function cosmetics for minimizing the pores are safe, mild, high-efficiency and durable, can minimize the pores from inside to outside, recover fineness, softness and smoothness, and enable skin to give out natural, clean and transparent gloss. The marine biological function cosmetics for minimizing the pores have various types, such as cream, emulsion, water agent, gel, spray or masks, have obvious and durable pore-minimizing effect and can serve as the common skin-care products or the cosmetics with the function of minimizing the pores. After the marine biological function cosmetics are not used, the pore bulky symptom is not rebounded.
Selective serotonin reuptake inhibitors (SSRIs) are among the most used and safe antidepressant drugs in the world. In previous studies, SSRIs have been found to cause an increase in brain gray matter volume in patients with major depression (MD). Optical coherence tomography (OCT) is a non-invasive medical imaging method that displays biological tissue layers by taking high-resolution tomographic sections. Changes in the thickness of the retinal nerve fiber layer (RNFL), a layer of the ganglion cell complex in the retinal layer of the eye and composed of ganglion cell axons, occur due to axonal damage in the retinal nerve tissue. Since RNFL is similar to brain gray matter tissue, recently neurological and psychiatric studies have been conducted to provide data on the neurodegeneration that occurs in the brain by OCT. However, in a recent cross-sectional study, contrary to what was expected, thinning of the retinal nerve fiber layer was detected in psychiatric patients using SSRI drugs compared to the healthy group, and this was attributed to a probable maculopathy caused by SSRIs in the eye. In this study, it is aimed to assess the probable cortical volume changes of the patients by measuring the changes in retinal nerve layers due to SSRI treatment in first-attack MD patients.
Home dialysis rates have improved little over the past five years. Lack of pre-dialysis patient education persists as an obstacle precluding greater improvement. In this study, barriers to chronic kidney disease (CKD) education at patient and provider levels were addressed using telehealth education for patients with CKD Stages 4-5 in a nonacademic outpatient nephrology practice. A quasi-experimental design was used to compare patients (n = 31) who received telehealth education to those in usual care. CKD Knowledge subscales of kidney function, slowing the progression of CKD, and options for treatment of kidney failure were measured pre-education, post-education, and three months later. There was no significant difference in CKD Knowledge scores over time or in treatment groups. Telehealth CKD education offers flexible options to address patient/provider barriers and potentially improve patient choice of home dialysis therapies.
Antibiotic XK-62-2, with mol. wt. 463 and empirical formula C20H41N5O7 (UV, IR and NMR spectra given) is produced by culturing a suitable Micromonospora strain, pref. M.sagamiensis ATCC 21826, M.sagamiensis var. flava ATCC 21827, M.sagamiensis var. nonreductans ATCC 21803 or M. nonreductans ATCC 21949 (new strains), and isolating XK-62-2 from the culture liquid. The above strains also produce gentamicin C complex antibiotics. XK-62-2 is closely related to gentamicin C2a and has high activity against Gram positive and negative bacteria, including resistant Proteus and Pseudomonas spp. It can be used in human and veterinary medicine and as an animal feed additive.
Cancer has become a major public health issue in China, seriously affecting population health, the economy, and social development. In 2022, there were an estimated 4.82 million new cancer cases and 2.57 million cancer-related deaths. Lung cancer, liver cancer, gastric cancer, colorectal cancer, esophageal cancer, pancreatic cancer, and breast cancer are the seven leading causes of cancer-related mortality. A successful earlier detection strategy would allow patients to receive timely interventions, improve treatment outcomes, enhance overall survival, and reduce the complexity and cost of treatment.

In this study, we will conduct a large-scale, prospective, multi-center cohort study, aiming to evaluate the utility of AI-assisted non-contrast CT for multi-cancer screening. The population consists of individuals who have undergone non-contrast abdominal or chest CT scans at Meinian Onehealth Health Examination Center or Shanghai Changhai Health Examination Center, with an expected enrollment of 1 million participants. A multi-cancer screening model via non-contrast CT, developed by Alibaba DAMO Academy, will be integrated into the PACS system of health examination centers. The imaging AI model will be used to automatically detect various cancerous lesions, including lung cancer, liver cancer, gastric cancer, colorectal cancer, esophageal cancer, pancreatic cancer, and breast cancer. Subjects identified with positive lesions by the AI model will be required to be referred to Shanghai Changhai Hospital for further imaging examinations (such as contrast-enhanced CT, MRI, Endoscopy, etc.) to confirm the final disease status and formulate a treatment plan. Additionally, the medical team should follow care pathways developed based on guidelines from NCCN and ACR, and if necessary, patients will be directed to the multidisciplinary team (MDT) clinic for specific cancer types to determine the diagnostic procedures. The ultimate goal of this study is to comprehensively assess the diagnostic performance metrics of the AI model for each of the seven cancer types individually. These metrics include, but are not limited to, sensitivity, specificity, and positive/negative predictive value. Particular emphasis will be placed on evaluating the model's efficacy in detecting early-stage, resectable tumors. The overarching aim is to determine whether the implementation of this AI-assisted screening approach could potentially lead to improved overall survival rates through earlier detection and intervention.
A data collection and processing system provides user and apparatus information from a CPAP apparatus (11) to a remote location. The system also allows the operating settings for the CPAP apparatus to be remotely programmed. Information is collected and stored in a digital memory in the CPAP apparatus. The CPAP apparatus is programmed to periodically transfer data to a central database server (15). The central database server can collect and store data from CPAP apparatus for a number of patients who undergo sleep therapy. A user can access the central database server over the internet (16) to obtain information. Each user is given access only to information for his or her patients. The user may provide data to the central database server for transmission to the CPAP apparatus during a subsequent connection that the CPAP apparatus makes to the central database server.
A device, preferably in the form of a skin patch, is disclosed for usage in the delivery of a contactant to human skin for the purpose of treating medical conditions responsive to contact immunotherapy, without the presence of medication to alleviate contact dermatitis induced by the contactant. The skin patch specifically induces a cell-mediated contact dermatitis in the treatment of skin disorders. Its anticipated use pertains to treatment of, for example, human papilloma virus infections, or warts. In a first embodiment, a pressure activated single chambered skin patch is topically applied and used for controlled release of contactant to human skin. In a second embodiment, a pressure activated two-chambered skin patch is topically applied and used for controlled release of a contactant to human skin. Alternatively, a single chambered skin patch is topically applied and hydrated by the contacted skin for release of contactant. In an additional embodiment, the contactant may be applied separately of the skin patch portion, in a manner that maintains the contactant in contact with the patient's skin for the predetermined period of time necessary to cause sufficient contact dermatitis to effect resolution of the medical condition.
The invention comprises a process for the preparation of polyene carboxylic acid derivatives by reacting an aldehyde of formula RCHO, where R is an hydrocarbon residue, having at most one ethereal oxygen atom, with a senecioic acid derivative of formula <FORM:0835526/IV (b)/1> where R1 is an alkoxy or NR2R3 group, in which R2 and R3 are hydrogen or an hydrocarbon radical, and may form part of a ring with the nitrogen atom in an inactive solvent in the presence of one or more of the following basic condensing agents: alkali metals, alkali metal amides, alkali hydrides or organo alkali metal compounds.  The polyene acid derivative can be hydrolysed to the free acid of formula <FORM:0835526/IV (b)/2> Amongst aldehydes specified are propylaldehyde isohexylaldehyde, crotonaldehyde, furfural, benzaldehyde, and b -ionylideneacetaldedehyde.  Alkyl, alkenyl, cycloalkyl, phenyl, benzyl, pyrrolidyl and piperidyl groups are specified for R2 and R3.  Amongst examples given are those of the preparation of 2-trans-4-cis - 3 - methyl - 5 - phenyl - 2,4 - pentadienic acid, trans Vitamin A acid and trans Vitamin A.  The process of the invention may be used to prepare Vitamin A derivatives of any desired steric configuration.  Specification 701,808 is referred to.
Severe hypertension occurred at a higher incidence in patients receiving bevacizumab products as compared to patients receiving chemotherapy alone. Across clinical studies the incidence of Grades 3-4 hypertension ranged from 5% to 18%.

Monitor blood pressure every two to three weeks during treatment with MVASI. Treat with appropriate anti-hypertensive therapy and monitor blood pressure regularly. Continue to monitor blood pressure at regular intervals in patients with MVASI-induced or -exacerbated hypertension after discontinuing MVASI. Withhold MVASI in patients with severe hypertension that is not controlled with medical management; resume once controlled with medical management. Discontinue in patients who develop hypertensive crisis or hypertensive encephalopathy.
The invention discloses idebenoneThe application in preparing the medicine for treating pulmonary hypertension. The invention belongs to the technical field of biological medicines. The invention constructs a rat model of pulmonary hypertension disease through Monocrotaline (Monocrotaline) induction. After the idebenone is injected into the abdominal cavity, the conditions of fur, diet, activity, death and the like of the pulmonary hypertension rat model are observed. The result shows that idebenone (shown in formula I) has the effects of remarkably improving pulmonary vascular remodeling of the pulmonary hypertension animal, relieving right ventricular hypertrophy and right heart failure, improving the living quality (improving food intake and water intake) of the pulmonary hypertension animal and improving the survival rate of the pulmonary hypertension animal. Therefore, the invention provides a wide application prospect of idebenone in the aspect of preventing and treating pulmonary hypertension diseases.
PURPOSE: We undertook a trial to test the efficacy of a technology-assisted health coaching intervention for weight management, called Goals for Eating and Moving (GEM), within primary care.
METHODS: This cluster-randomized controlled trial enrolled 19 primary care teams with 63 clinicians; 9 teams were randomized to GEM and 10 to enhanced usual care (EUC). The GEM intervention included 1 in-person and up to 12 telephone-delivered coaching sessions. Coaches supported goal setting and engagement with weight management programs, facilitated by a software tool. Patients in the EUC arm received educational handouts. We enrolled patients who spoke English or Spanish, were aged 18 to 69 years, and either were overweight (body mass index 25-29 kg/m2) with a weight-related comorbidity or had obesity (body mass index ≥30 kg/m2). The primary outcome (weight change at 12 months) and exploratory outcomes (eg, program attendance, diet, physical activity) were analyzed according to intention to treat.
RESULTS: We enrolled 489 patients (220 in the GEM arm, 269 in the EUC arm). Their mean (SD) age was 49.8 (12.1) years; 44% were male, 41% Hispanic, and 44% non-Hispanic Black. At 12 months, the mean adjusted weight change (standard error) was -1.4 (0.8) kg in the GEM arm vs -0.8 (1.6) kg in the EUC arm, a nonsignificant difference (P = .48). There were no statistically significant differences in secondary outcomes. Exploratory analyses showed that the GEM arm had a greater change than the EUC arm in mean number of weekly minutes of moderate to vigorous physical activity other than walking, a finding that may warrant further exploration.
CONCLUSIONS: The GEM intervention did not achieve clinically important weight loss in primary care. Although this was a negative study possibly affected by health system resource limitations and disruptions, its findings can guide the development of similar interventions. Future studies could explore the efficacy of higher-intensity interventions and interventions that include medication and bariatric surgery options, in addition to lifestyle modification.
[PROBLEMS] It is well known that nonsteroidal antiinflammatory drugs, which have been used in treating many painful diseases such as arthritis, have side effects of inducing lesions such as inflammation, sore and ulcer in the digestive tract mucosae. Thus, many of these drugs are restricted in administration dose and administration period. It is highly advantageous, if possible, for animal lovers, veterinarians, etc. to prevent/treat these side effects of the nonsteroidal antiinflammatory drugs on the digestive tracts. [MEANS FOR SOLVING PROBLEMS] As the results of extensive studies on the onset mechanism of the side effects of nonsteroidal antiinflammatory drugs on the digestive tracts with the use of dogs and cats, it is clarified that dietary fiber components strongly participate in the induction of the lesions in the digestive tract mucosae. Based on the results of these studies, the side effects of nonsteroidal antiinflammatory drugs on the animal digestive tracts can be efficaciously prevented/treated by feeding animals with a feed containing not more than 2% by weight, in terms of dry matters, of dietary fiber.
All eligible patients will receive a starting lenvatinib dose of 24 mg daily taken orally for each 4-week cycle. Patients may remain on study until progression of disease or unacceptable toxicity. Alternatively, Lenvatinib may be dissolved in fluid per the Food and Drug Administration (FDA) label and administered orally or via a feeding tube.
The patients who after randomization are allocated to the treatment arm will receive 12 months of treatment in a pragmatic metabolic clinic. Patients will receive measurements/monitoring at least 3 times during the study period: Upon enrolment, after 6 months and after 12 months.
Placebo cream (without the drug substance) is applied to the entire face twice a day. Giving cream in the morning and at night. Evaluation will be carried out on days 28 and 56.
Video coaching exercises group: patients will perform physical exercises according to a video coaching program 3 times weekly during 6 months. The on-line program has been designed especially for this study.
OBJECTIVE: There is a lack of effective biomarkers for predicting the distant metastasis in nasopharyngeal carcinoma (NPC). We aimed to explore the expression of FAP+Cancer-associated fibroblasts (CAFs) derived CXCL1 in NPC and its predictive values for distant metastasis and correlation with PD-L1 expression.
MATERIALS AND METHODS: A total of 345 patients with locoregionally advanced NPC were retrospectively enrolled (the training cohort: the validation cohort = 160:185). Co-expression of CXCL1 and FAP and the expression of PD-L1 were detected by multi-immunofluorescence staining and immunohistochemistry, respectively. The primary end-point was distant metastasis-free survival (DMFS). The Kaplan-Meier method was used to calculate the survival. The Cox proportional hazards model was used to assess prognostic risk factors.
RESULTS: A novel CXCL1+_FAP+ phenotype in CAFs was identified in NPC and then used to divide patients into low and high risk groups. Both in the training cohort and validation cohort, patients in the high risk group had poorer DMFS, overall survival (OS), progression-free survival (PFS) and locoregional relapse-free survival (LRFS) than patients in the low risk group. Multivariate analysis revealed CXCL1+_FAP+ phenotype was an independent prognostic factor for DMFS, OS, PFS and LRFS. Further results showed patients in the high risk group had higher PD-L1 expression than those in the low risk group.
CONCLUSION: Our study showed CXCL1+_FAP+ phenotype in CAFs could effectively classified locoregionally advanced NPC patients into different risk groups for distant metastasis and might be a potential biomarker for anti-PD-1/PD-L1 immunotherapy.
An inbound message including medical record content may be received. The inbound message may indicate a healthcare entity and a vendor entity. It may be determined, from the healthcare entity and stored correspondences between medical record formats and healthcare entities, that the medical record content of the inbound message is in a first medical record format. Which configuration record of stored configuration records specifying combinations of sets of rules may be determined to apply as a translation to the inbound message based upon the medical record content of the inbound message and the first medical record format. The sets of rules as indicated by the configuration record may be accessed and applied to the inbound message to translate the medical record content in the inbound message from the first medical record format to the standardized format. The standardized format may be transmitted to the vendor entity.