anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Chronic abdominal aortic occlusive disease (CAAOD) is an uncommon manifestation of antiphospholipid syndrome (APS), impacting cardiovascular health and peripheral arterial circulation. We investigated CAAOD in antiphospholipid antibodies (aPL)-positive patients, aimed to offer comprehensive clinical and radiological insights.
METHODS: aPL-positive patients with arterial thrombotic events were categorised into CAAOD and non-CAAOD. Extensive data, including clinical features, radiological images and outcomes, were analysed.
RESULTS: This case-control study involved 114 patients who experienced arterial events from 2013 to 2021, revealing 12 patients with abdominal aortic stenosis or occlusion. The CAAOD group, predominantly young (36.67±11.83) males (75.00%), exhibited significantly higher rates of critical smoking habits (66.67% vs 25.49%, p=0.006) and hyperhomocysteinaemia (66.67% vs 31.37%, p=0.026). Radiological findings showed long-segment infrarenal aorta stenosis in CAAOD, occasionally involving renal and common iliac arteries. The lesions presented varying degrees of stenosis, including smooth lumen narrow and total vascular occlusion. Treatment modalities typically involved interventions or surgery, complementing anticoagulation therapy.
CONCLUSION: The study shed light on the rare occurrence of CAAOD in APS, highlighting the roles of smoking and hyperhomocysteinaemia as notable risk factors. These findings emphasised the significance of early diagnosis and management of CAAOD.
Clients who select the 8-week course will receive access to an ICBT course which consists of five lessons spread across the span of eight weeks. The content in this course is not student-specific. Clients have access to diverse additional resources (e.g., managing panic, assertive communication) throughout the course. Clients will receive eight weeks of optional therapist support.
BACKGROUND There is a lack of accurate models to predict amyotrophic lateral sclerosis (ALS) disease course and outcomes. As a result, risk assessment and counseling, the timing of interventions, and their stratification in clinical trials are difficult. This study aimed to evaluate the association between symptoms at presentation and mortality. MATERIAL AND METHODS A single veterans hospital reviewed the electronic records of 105 veterans with ALS who were periodically followed in our ALS clinic between 2010 and 2021. A survival decision tree (≤3 or >3 years) was generated based on the statistical median survival of our data. The variables known to influence survival when alive were compared to patients who died. RESULTS The (mean±SD) age at onset was 62±11 years, M/F ratio 101: 4, and 90% were non-Hispanic whites. The initial score for the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) was 31±8.3. Dysarthria and shortness of breath (SOB) were present on initial presentation in 52 (49.5%) and 32 (30.5%) patients, respectively. Deaths occurred in 80 (76.2%) patients during the study period. The main cause of death was respiratory disease (failure and pneumonia, n=43 53.75%). Patients survived for >3 years on initial presentation with normal respiration and speech, compared to ≤3 years of survival in patients with dysarthria and SOB, irrespective of age. CONCLUSIONS This study suggests that for veterans with ALS, the main predictors of shorter survival were respiratory status and speech disorder on initial presentation to the clinic.
PROBLEM TO BE SOLVED: To efficiently, simply and inexpensively separate and purify IgY without spoiling its physiological activity from an IgY-contg. liq. by means of liq. chromatography using a solid phase material whose surface consists of a metal salt of pyrophosphoric acid or a metal salt of metaphosphoric acid. SOLUTION: In a method wherein, after lipoprotein, etc., existing in yolk of birds and bonded with lipid and an IgY-contg. liq. are separated from each other, adulterant proteins in the IgY-contg. liq. and IgY are separated by means of liq. chromatography, as a solid phase material for adsorption and desorption of IgY and the adulterant proteins, a material whose surface consists of a metal salt of pyrophosphoric acid or metaphosphoric acid is used. As the metal of the metal salt, such metals as magnesium, strontium, manganese, iron, aluminum, zirconium and titanium are pref. Zirconium pyrophosphate and titanium pyrophosphate are especially pref. as the solid phase material.
Part B is a Phase 2, open-label, randomized continuation design comparing crizotinib alone versus the combination of crizotinib + AT13387 at the MTD established in Part A. Part B will enroll 128 patients with NSCLC who have been treated with crizotinib for at least 8 weeks and are still tolerating treatment without evidence of disease progression.
Goat coccidiosis compromises animal welfare, reduces productivity and may cause mortality and delayed growth rates in goat kids around the weaning period worldwide. This field study was conducted to evaluate the efficacy of metaphylactic treatments with two doses of toltrazuril (20 or 40 mg/kg body weight - BW, p. o.), at different timing, in kids naturally infected with Eimeria spp. A total of 97 healthy goat kids (Majorera milk aptitude breed) were divided into five groups, depending on the age of treatment (2 or 7 weeks). One group remained untreated as a negative control until the end of the study. Faecal oocyst shedding, faecal consistency, and body weight of the animals were monitored at day 0 and at weekly intervals. Counts of oocysts per gram of faeces (OPG) were determined by a modified McMaster technique. Morphometric identification of Eimeria species was carried out on individual faecal samples from each experimental group after oocyst sporulation. Goat kids treated at two weeks of age maintained OPG values close to zero during the 5 weeks post-treatment and, overall, had lower faecal oocyst counts than untreated control animals. No significant differences were observed between the two doses of toltrazuril used in two-week-old treated animals. By contrast, when treatment was carried out at seven weeks of age, the dose of 40 mg/kg BW of toltrazuril reduced oocyst levels for longer and to a greater extent than the 20 mg/kg dose. Irrespectively of the treatment and dose, toltrazuril delayed the appearance of pathogenic Eimeria species, i. e. Eimeria ninakohlyakimovae and Eimeria arloingi. As a whole, Eimeria christenseni, with a rather moderate pathogenicity, was highly predominant throughout the study period, including the untreated control group, which was probably the reason why clinical signs of coccidiosis were barely observed throughout the experiment. Under these circumstances, the positive effect of toltrazuril on body weight condition observed in some treated groups was difficult to correlate to the timing and doses. Metaphylactic treatments with 20 mg/kg BW toltrazuril given at two weeks of age are sufficient to control oocyst excretion in goat kids; whereas if administered later in 7-week-old animals, thereby coinciding with the frequently observed peak of oocyst elimination in goat kids under field conditions, a higher dose might be advisable to prevent environmental contamination with infectious oocysts.
PURPOSE:To enable comparison of a radiation image for diagnosis under observation with a past radiation image for diagnosis without using hard copies, by refreshing and displaying side by side both a radiation image for diagnosis based on a radiation image signal for diagnosis input by a retrieval means and a read means and a radiation image for comparison based on a radiation image signal for comparison obtained by the retrieval means. CONSTITUTION:A radiation image signal S1 carrying radiation image information is obtained from a storage medium by a read means 1, subjected to an image processing by an image processing means 2, and sent to a display means 3. The radiation image signal S1 is also sent to and stored in a storage means 6. A piece of ID information S2 of a subject corresponding to the radiation image signal S1 is sent from an ID information input means 4 to a storage means 6 and stored in it. When the ID information S2 is sent from the ID information input means 4 to a retrieval means 5, a radiation image signal S3 for comparison of the same subject as that of the radiation image signal S1 for diagnosis is obtained from radiation image signals stored in the storage means 6. The radiation image signal S3 for comparison is subjected to an image processing by an image processing means 2 and sent to a display means 3. The display means 3 refreshes and displays the radiation image for diagnosis and the radiation image for comparison side by side.
A customized and supervised endurance exercise training program that will last 4 months (16 weeks). The regimen will be tailored to the individual fitness level, and will be a combination of Arm A and Arm B, described above. At each session, the participant will complete aerobic training on a stationary bicycle and also resistance training using stationary weight machines. The exercise program will consist of three supervised sessions per week. Each session will last approximately 30-90 minutes.
From Cycle 0 to Cycle 2, the subject will receive the preset dose of EX103 once a week (QW), and from Cycle 3, the subject will receive the preset dose of EX103 once every two weeks (Q2W). The recommended dose is MTD or OBD, and a cycle of treatment is 28 days.
Itch is an unpleasant sensation that induces a desire to scratch. Chronic itch is accompanied by inflammatory skin diseases and causes repetitive scratching leading to tissue damage. The thyrotropin-releasing hormone analog taltirelin exerts analgesic effects on acute and chronic pain by activating the descending inhibitory systems. However, little is known regarding its effects on acute and chronic itch. In this study, we examined the effects of taltirelin on acute and chronic itch. Subcutaneous injection of chloroquine increased the number of scratching bouts in 30 min, whereas intraperitoneal injection of taltirelin reduced these episodes in a dose-dependent manner. In addition, chronic itch induced by diphenylcyclopropenone treatment was alleviated by taltirelin injection. These findings indicate that taltirelin alleviates acute and chronic itch in mice, and can be a potent therapeutic antipruritic drug.
PURPOSE: To obtain a new hybridoma 27D57, having the ability to produce a human type monoclonal antibody, having high specificity for lung cancer, reactive with a cell membrane antigen in the lung cancer cell and useful as a testing agent and a therapeutic agent for the lung cancer. CONSTITUTION: A lymph node of a patient suffering from lung cancer is aseptically extirpated by surgical operation and immersed in a cold culture medium. The lymph node is then chopped with a pair of scissors to remove insoluble parts with a double gauze. The resultant part is centrifuged at a low speed to collect a lymphocyte as a precipitate. The collected lymphocyte is fused to a cell of a myeloma and cultured in a hybridoma selecting culture medium. The reactivity of the resultant hybridoma with a pumonary cancer cell is screened to carry out cloning.  Thereby, the resultant new hybridoma 27D57 (FERM P-14120) contains an antigen present on the cell membrane of a lung cancer cell A549 strain and further in the humor of a patient suffering from the lung cancer and a tissue of the patient suffering from the lung cancer and has the productivity of an IgM human type monoclonal antibody having an amino acid sequence of formula I as an antibody heavy chain and an amino acid sequence of formula II as an antibody light chain.
The purpose of this Phase II, mechanistic Sequential, Multiple Assignment, Randomized Trial (SMART) is to test the effects of 6-month aerobic exercise on aerobic fitness and MRI and plasma biomarkers in community-dwelling older adults with early Alzheimer's disease (AD). The aims are to (I) test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; (II) identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and (III) examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. This trial builds on our previous work showing inter-individual differences in VO2peak responses to moderate-intensity continuous training (MICT); an ability of plasma neurofilament light chain (NfL) to predict cognition; and 6-month MICT maintained memory, reduced WMH, affected plasma p-tau181, and improved physical function, QoL, and caregiver distress. Aerobic exercise is a promising treatment for Alzheimer's disease (AD) and AD-related dementia (ADRD) but has shown mixed effects on cognition, physical function, behavioral and psychological symptoms of dementia (BPSD), quality of life (QoL), and caregiver burden. These findings are likely due to inter-individual differences in aerobic fitness responses, which have long been established in adults using VO2peak and were first reported in AD/ADRD by our team. Most AD/ADRD exercise trials did not measure VO2peak and those that reported large inter-individual differences in VO2peak responses to MICT. Mechanistically, animal studies support aerobic exercise modifying AD's ATN biomarkers (Amyloid-beta \[Aβ\], Tau, and Neurodegeneration), but human studies are few and have conflicting findings. Hence, precision exercise is critical to improving VO2peak responses with alternative interventions (high-intensity interval training (HIIT) or combined aerobic \& resistance exercise (CARE)). Because VO2peak can improve and peak from 3 months of MICT, 3 months is an ideal time to identify MICT non-responders and initiate HIIT or CARE.
Baduanjin sequential therapy consists of Six different movements including the preparatory phase. The session will account for 30 minutes twice a day for four weeks.
The invention discloses an antacid preparation with a novel release behavior. The preparation is a gastric-soluble rapid-release preparation prepared from a proton pump inhibitor, a prescribed amount of an acid neutralizing agent, a certain amount of a solubilizer, and other common pharmaceutically acceptable excipient. The proton pump inhibitor is not stable to acid. With the certain amount of acid neutralizing agent, a direct effect for inhibiting gastric acid can be developed, and gastric acid can be neutralized, such that pH value in the stomach can be increased rapidly, the proton pump antacid agent is dissolved fast, and medicine reaction time is accelerated. With a micronization manner, medicine particle size can be reduced, such that the medicine can be dissolved fast, and medicine effect can be developed fast. The preparation provided by the invention has stable quality and substantial effect.
High-grade serous carcinoma of the ovary, fallopian tube and peritoneum (HGSC), the most common type of ovarian cancer, ranks among the deadliest malignancies. Many HGSC patients have excess fluid in the peritoneum called ascites. Ascites is a tumour microenvironment (TME) containing various cells, proteins and extracellular vesicles (EVs). We isolated EVs from patients' ascites by orthogonal methods and analyzed them by mass spectrometry. We identified not only a set of 'core ascitic EV-associated proteins' but also defined their subset unique to HGSC ascites. Using single-cell RNA sequencing data, we mapped the origin of HGSC-specific EVs to different types of cells present in ascites. Surprisingly, EVs did not come predominantly from tumour cells but from non-malignant cell types such as macrophages and fibroblasts. Flow cytometry of ascitic cells in combination with analysis of EV protein composition in matched samples showed that analysis of cell type-specific EV markers in HGSC has more substantial prognostic potential than analysis of ascitic cells. To conclude, we provide evidence that proteomic analysis of EVs can define the cellular composition of HGSC TME. This finding opens numerous avenues both for a better understanding of EV's role in tumour promotion/prevention and for improved HGSC diagnostics.
The control group will receive a simplified tool including only the education message. The methodology will ensure that potential confounders by differences in nonspecific support and attention could be adjusted. Regular messages about prevention and cure of CHD will be sent to both groups four times a week. The short texts will be selected from the guidelines in China to avoid misinformation. There are also some pictures or videos that help patients change their behavior. Patients will be followed up for 4/8/12 months after admission through mHealth tools or telephone.
Hydromorphone hydrochloride injection [high potency formulation (HPF)] contains hydromorphone, a Schedule II controlled substance. As an opioid, hydromorphone hydrochloride injection (HPF) exposes users to the risks of addiction, abuse, and misuse [see Drug Abuse and Dependence (9)]. 

Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed hydromorphone hydrochloride injection (HPF). Addiction can occur at recommended dosages and if the drug is misused or abused. 

Assess each patient's risk for opioid addiction, abuse, or misuse prior to prescribing hydromorphone hydrochloride injection (HPF), and monitor all patients receiving hydromorphone hydrochloride injection (HPF) for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as hydromorphone hydrochloride injection (HPF), but use in such patients necessitates intensive counseling about the risks and proper use of hydromorphone hydrochloride injection (HPF) along with intensive monitoring for signs of addiction, abuse, and misuse. 

Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing hydromorphone hydrochloride injection (HPF). Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.
DL-3-n-butylphthalide (NBP) is isolated from the seeds of Apium graveolens L., and has been recently used as a neuroprotective agent for acute ischemic stroke. The present study aimed to determine the efficacy and safety of the combined use of dual antiplatelet therapy (DAPT) and NBP for treating of acute ischemic stroke in rats and to explore the synergistic mechanism of this treatment strategy in rat middle cerebral artery occlusion models. The efficacy of DAPT combined with NBP was evaluated by determining neurological deficits, infarction status, and histological changes. Changes in body weight, blood glucose level, blood count, and serum biochemical parameters were detected to evaluate the safety. To explore the synergistic pharmacological mechanism, the mRNA expression and protein levels of key proteins in the pyroptosis-inflammatory pathway, and the pyroptosis ratio of microglias were examined. Compared with the administration of NBP or DAPT alone, combination of them significantly improved neurological deficits, reduced infarct area, and repaired tissue injury and inflammation after cerebral ischemia. No hepatorenal toxicity was observed. The mRNA expression and protein levels of key proteins in the pyroptosis-inflammation pathway, and the pyroptosis ratio of microglias were significantly downregulated in the combined administration group than in the monotherapy group. We demonstrated that the combined use of NBP and DAPT exhibits better efficacy and high safety and plays a synergistic role by inhibiting the pyroptosis-inflammation pathway in the brain tissues, particularly in microglial cells.
Apparatus and associated methods involve generating a voucher redeemable by a user to receive a prepaid healthcare service in response to receiving payment for the service at a price based on a location of the service, and applying a prepaid amount to a health insurance claim amount for the user. The payment may be a virtual fund or actual currency payment. The service may be specified based on physician, facility, location and time, allowing price adjustments based on geographic cost differences. Some embodiments may provide a marketplace system configured to allow virtual funds for prepaid services and actual currency to be created, transferred, exchanged, and exchanged. Based on redeeming the credentials, the user may receive the prepaid service. Various embodiments may exchange healthcare bundles, including services and medications, for prices discounted based on the bundles. The healthcare bundle can be presented in a shopping cart format, allowing the user to prepay for customized bundles.
The invention discloses a kind of Radix Notoginseng medicinal extract extraction process, the present invention is the following steps are included: a. cleans Radix Notoginseng raw material；B. Radix Notoginseng raw material is carried out dry for the first time；C. Radix Notoginseng raw material is cut；D. second of drying is carried out to Radix Notoginseng raw material；E. Radix Notoginseng raw material is crushed；F. concentration is extracted to Radix Notoginseng raw material；Using blasting ozone in service sink, it carries out disinfection to Radix Notoginseng blade, Radix Notoginseng stem and sanchi flower, spending for Radix Notoginseng individually carries out ozonization simultaneously, disinfecting times different from cauline leaf using flower in this way, and clear water is cooperated to clean, whole strain Radix Notoginseng is effectively eliminated after being cleaned, the pesticide residue of each portion faces is by effective cleaning removal, the content of beary metal in plant is removed simultaneously, it, can be from wash phase it is prevented that the residual of harmful substance compared with ethyl alcohol cleaning；Achieve the purpose that efficiently to remove the pesticide residue and content of beary metal in Notogineng Extract with extremely simple step.