anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a remote-operated nanorobot system performing a drug delivery and release function and a control method thereof and, more specifically, to a remote-operated nanorobot system performing a drug delivery and release function, which is capable of actively controlling drug release through an external stimulation device after accurately positioning a nano-sized drug delivery structure (nanorobot) in an affected part of a subject, and to a control method thereof. To this end, the remote-operated nanorobot system performing a drug delivery and release function according to the present invention comprises: a nanorobot; a magnetic field generation device; an external stimulation device; and an image photographing unit. The nanorobot is driven by a magnetic force generated in an external magnetic field to move in a body of a subject and to deliver drugs. Also, the magnetic field generation device generates a magnetic field to move the nanorobot to an affected part in the body of the subject. The image photographing unit is capable of photographing the inside of the body of the subject to detect a moving path and a position of the nanorobot. In addition, the external stimulation device is capable of releasing drugs by applying external stimulation to the nanorobot. Therefore, the remote-operated nanorobot system of the present invention has an effect of improving drug delivery performance and treatment efficiency, and remarkably reducing side effects caused by drug injection. Further, the remote-operated nanorobot system of the present invention has an effect of effectively administering drugs to an affected part without individual deviation according to an in vivo specific environment and structure of a patient.
Physical activity is reduced in COPD patients and has a negative effect in the morbidity and mortality of this condition. Unfortunately, usual advice is not good enough to reverse the sedentary condition in COPD patients. Pedometers are broadly used to measure and to enhance physical activity in COPD but their effects in COPD are not well known. The aim of the study is to determine the effects of a program using pedometers as a feedback in stable ex smokers COPD patients. Patients are recruited for a 3 months individual program promoting daily physical activity enhancement and are randomly assigned either to a pedometer-based program (experimental group) or to usual care (control group, the measurements at the beginning and at the end of the study are: anthropometrics, Spirometry, dyspnea, quality of life, exercise capacity and the average one week daily steps. Also the number of acute exacerbations during the follow up are recorded.
The utility model relates to a cold compress pain relieving paste, which is formed by combining a protective layer, a polymeric hydrogel layer and a ventilation layer sequentially. The protective layer is a polyethylene film layer. The polymeric hydrogel layer is prepared by mixing Chinese herbal extract and polymeric hydrogel. The ventilation layer is a non-woven fabric layer. The cold compress pain relieving paste is convenient to use, i.e. the protective layer is torn off and the polymeric hydrogel layer is directly adhered to an affected part. The polymeric hydrogel layer has the characteristics of high stability and durable effect. The polymeric hydrogel layer is prepared by mixing the Chinese herbal extract and the polymeric hydrogel, and thus, the cold compress pain relieving paste cannot cause damage to organism such as spleen, stomach, liver, kidney and the like in the using process of a patient and is particularly suitable for cold compress pain relief of various acute sprains and fractures and treatment of various osteoarticular diseases.
The present invention relates to Chinese herbal medicine which is Mongolian medicine powder for mainly treating children's diarrhea and adult andropathy. The medicine is composed of gobi red narrow-leaved oleaster fruit, desert cynomorium songaricum, Alashan camelus bactrianus cheese and high-quality crystal sugar, and the components are compounded in equal amount and are dried, powdered and sieved. A sieve has more than 100 meshes. An infant takes one pack with 2g of medicine, and the adult with andropathy takes one pack with 5g of medicine. The present invention adopts a disease treatment mode of combining treatment with eating, and is suitable for tastes of infants and modern adults. The present invention has the advantages of purity, fragrancy and sweetness, economy, practicality, homology of treatment and eating, good mouth feeling and absorption, disease treatment, body nourishment, no toxic side effect, easy material taking, low cost and great popularization value; the medicine can stop diarrhea for infantile diarrhea and can prevent diarrhea for infants without diarrhea at ordinary times. Both infants and adults like the medicine.
One of the bottlenecks to bringing new therapies to the clinic has been a lack of vectors for delivering novel therapeutics in a targeted manner. Cell penetrating peptides (CPPs) have received a lot of attention and have been the subject of numerous developments since their identification nearly three decades ago. Known for their transduction abilities, they have generally been considered inert vectors. In this review, we present a schema for their classification, highlight what is known about their mechanism of transduction, and outline the existing literature as well as our own experience, vis a vis the intrinsic anti-inflammatory properties that certain CPPs exhibit. Given the inflammatory responses associated with viral vectors, CPPs represent a viable alternative to such vectors; furthermore, the anti-inflammatory properties of CPPs, mostly through inhibition of the NF-κB pathway, are encouraging. Much more work in relevant animal models, toxicity studies in large animal models, and ultimately human trials are needed before their potential is fully realized.
FIELD: pharmaceutical industry. SUBSTANCE: described are amidinonaphthyl derivatives of general formula I wherein R 1  is hydrogen or -A-W-R 4 ; A is group of formula  , group of formula   or -SO 2 -; X is oxygen or sulfur atom; W is single bond or group of formula NR 5 , R 4  is hydroxyl, lower alkoxy, lower alkyl which is substituted, or heteroaryl containing 1-2 heteroatoms selected from sulfur and nitrogen which is substituted provided that when w is group of formula NR 5 , R 4  is further hydrogen atom, but is not hydroxy or lower alkoxy group; R 5  is hydrogen atom, carbamoyl, lower alkoxycarbonyl, mono-or dilower alkylaminocarbonyl, lower alkylsulfonyl, mono- or dilower alkylaminothiocarbonyl, lower alkyl which is substituted, or lower alkanoyl which is substituted; R 2  is lower alkyl; R 3  is hydrogen atom or lower alkoxycarbonyl; B is lower alkylene or carbonyl; n is 0 or 1, or pharmaceutically acceptable salts thereof. Said derivatives produce inhibiting effect against aggregation of thrombocytes caused by effect of activated factor X of coagulating blood system, and are useful as agents for preventing formation of thrombuses. Also described are intermediate products for preparing said derivatives and pharmaceutical compositions comprising said derivatives. EFFECT: improved properties of the pharmaceutical composition. 12 cl, 102 ex, 11 tbl
This is a survey study to evaluate the feasibility and effectiveness of an affordable, $400 flat rate, same-day consultation, simulation, and delivery of a single fraction of palliative radiation therapy for patients with symptomatic bony metastatic disease who are currently enrolled in hospice. Treatment planning and delivery of palliative radiotherapy will utilize "standard of care" techniques. A physician survey of feasibility will be conducted on the treatment day. Patient surveys will conducted on the day of treatment and at 2 weeks, 4 weeks, 2 months, 3 months, 4 months, 5 months, and 6 months after treatment.
A novel, closed loop drug delivery system has been developed where the presence or absence of an external compound determines delivery of a drug from a bioerodible polymer. In the described delivery system hydrocortisone is incorporated into a n-hexyl half ester of a methyl vinyl ether-maleic anhydride copolymer and the polymer-drug mixture fabricated into discs. These are then coated with a hydrogel containing immobilized urease. In a medium of constant pH and in the absence of external urea, the release of hydrocortisone is that normally expected for that polymer at the given pH. In the presence of external urea, ammonium bicarbonate and ammonium hydroxide is generated within the hydrogel which accelerates polymer erosion and hence drug release. Drug delivery rate increase is proportional to the amount of external urea and is reversible, that is, when external urea is removed, the rate of drug release gradually returns to its original value.
INTRODUCTION: Pain catastrophizing is an exaggerated negative orientation to painful stimuli which in obstetric patients is associated with fear of overwhelming labor pain and negative pain-related outcomes. This study aimed to quantitatively examine the association of pain catastrophizing with maternal labor pain outcomes.
METHODS: We conducted a prospective observational study of women admitted for a vaginal trial of labor. Subjects completed the 13-item Pain Catastrophizing scale (PCS) questionnaire (scored 0 to 52, higher scores representing greater catastrophizing). Pain was assessed at baseline and at request for neuraxial labor analgesia. Labor and postpartum pain intensity was assessed as the average area under the pain intensity by time curve. Pain at request for analgesia, labor pain, postpartum pain, analgesic consumption, and quality of recovery was compared between high (PCS ≥ 17) and low catastrophizing groups.
RESULTS: Data from 138/157 (88%) subjects were included in the analysis. Median (IQR) pain scores at request for analgesia were 9 (8,10) and 8 (6,9), a difference of 1 (95% CI 0 to 2.5, P = 0.008) in high-catastrophizing and in low-catastrophizing groups, respectively. Adjusted pain during labor, postpartum pain and opioid analgesic use were not significantly different. High-catastrophizers reported less comfort, ability to mobilize and less control during hospitalization. Post-discharge there were no differences in pain or analgesic use.
CONCLUSION: We did not observe greater labor or post-delivery pain or increased analgesic use in high-catastrophizing parturients. High catastrophizers reported greater pain when requesting analgesia, which is consistent with the role of catastrophizing in intensifying the experience of pain.
PCT No. PCT/JP97/03777 Sec. 371 Date Jul. 28, 1998 Sec. 102(e) Date Jul. 28, 1998 PCT Filed Oct. 20, 1997 PCT Pub. No. WO98/17785 PCT Pub. Date Apr. 30, 1998The present invention provides a method for producing a rotavirus antigen of which the mass culture is difficult, comprising cloning a cell highly permitting the proliferation of rotavirus from a cell culture; preparing a cloned cell adapted-rotavirus strain by passaging a rotavirus in the resulting cloned cell strain and adapting the rotavirus to the cloned cell strain; culturing as a seed virus the adapted rotavirus strain or a reassortant prepared by using the adapted rotavirus strain as a parent strain; and isolating and purifying the rotavirus antigen from the culture medium of the seed virus; and additionally provides an rotavirus antigen, a vaccine against rotavirus infections, and a diagnostic agent of the diseases, as produced by using the antigen. These antigen, vaccine and diagnostic agent can make great contributions to individual fields of the fundamental research works and clinical application, relating to rotavirus infections.
Patients will undergo routine phacoemulsification, pars plana vitrectomy, ILM peel and gas fluid exchange with 14% C3F8. They will be advised to avoid supine posturing for seven days after surgery, but will not be advised to posture in the face down or prone position.
BACKGROUND: The tea plant Camellia sinensis (L.) O. Kuntze is a perennial crop, invaded by diversity of insect pest species, and pink tea mite is one of the most devastating pests for sustainable tea production. However, molecular mechanism of defense responses against pink tea mites in tea is still unknown. In this study, metabolomics and transcriptome profiles of susceptible and resistant tea varieties were compared before and after pink tea mite infestation.
RESULTS: Metabolomics analysis revealed that abundance levels of polyphenol-related compounds changed significantly before and after infestation. At the transcript level, nearly 8 GB of clean reads were obtained from each sequenced library, and a comparison of infested plants of resistant and susceptible tea varieties revealed 9402 genes with significant differential expression. An array of genes enriched in plant pathogen interaction and biosynthetic pathways of phenylpropanoids showed significant differential regulation in response to pink tea mite invasion. In particular, the functional network linkage of disease resistant proteins, phenylalanine ammonia lyase, flavanone -3-hydroxylase, hydroxycinnamoyl-CoA shikimate transferase, brassinosteroid-6-oxidase 1, and gibberellin 2 beta-dioxygenase induced dynamic defense signals to suppress prolonged pink tea mite attacks. Further integrated analyses identified a complex network of transcripts and metabolites interlinked with precursors of various flavonoids that are likely modulate resistance against to pink tea mite.
CONCLUSIONS: Our results characterized the profiles of insect induced metabolic and transcript reprogramming and identified a defense regulatory network that can potentially be used to fend off pink tea mites damage.
It is estimated that approximately 80% of patients with schizophrenia have reduced cognitive functions, representing problems with attention, verbal memory, short-term memory and executive functions (1-3). These impairments might have an impact on the patients ability to complete rehabilitation programmes, apply learned strategies to social problems, develop work skills and manage daily life (4,5). The effect of Cognitive Adaptation Training has been tested as a psychosocial treatment including training of compensatory strategies in order to sequence patient's adaptive behaviour, showing promising results concerning improved social functions (6). There are however no solid evidence for these statements. The existing few studies investigating the effect of Cognitive Adaptation Training (6-8) are underpowered (small sample sizes) and have a lack of younger patients, which limits the conclusions that can be drawn from the results of the improvement. The present trial employs a prospective design of 26 weeks with a follow-up period of 9 months after inclusion. The study will enroll 164 consecutively recruited participants from three Danish out-patient teams for young adults with a first episode of psychosis.
Clinical Presentation

Acute overdose with meperidine hydrochloride tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death. Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations [see Clinical Pharmacology (12.2)].

Accumulation of normeperidine as in chronic use or possibly following introduction of a concomitant CYP3A4 inducer presents as excitatory syndrome including hallucinations, tremors, muscle twitches, dilated pupils, hyperactive reflexes, and convulsions.

Treatment of Overdose

In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures (including oxygen and vasopressors) in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques.

The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to meperidine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to meperidine overdose.

Because the duration of opioid reversal is expected to be less than the duration of action of meperidine in meperidine hydrochloride tablets, carefully monitor the patient until spontaneous respiration is reliably reestablished. If the response to an opioid antagonist is suboptimal or only brief in nature, administer additional antagonist as directed by the product’s prescribing information.

In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity the withdrawal symptoms experienced will depend on the degree of physical dependence and the dose of antagonist administered. If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist.
BACKGROUND: Currently, the high recurrence rate still forms severe challenges in hepatocellular carcinoma (HCC) treatment. The GALAD score, including age, gender, alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) was developed as a diagnostic model. However, evidence is still lacking to confirm the capability of the GALAD score to predict the recurrence of HCC.
METHODS: This study included 390 HCC patients after local ablation at Beijing You'an Hospital from January 1, 2018, to December 31, 2022. Firstly, the area under the receiver operating characteristic (ROC) curve (AUC) was calculated to assess the predictive capability of the GALAD score. Then, the Kaplan-Meier (KM) curve and log-rank test were used to compare the prognosis between two groups classified by GALAD score. Finally, a nomogram for high-risk patients was established by Lasso-Cox regression. It was assessed by ROC curves, calibration curves, and decision curve analysis (DCA).
RESULTS: The ROC curve (AUC: 0.749) and KM curve showed the GALAD score had good predictive ability and could clearly stratify patients into two groups through the risk of recurrence. Prognostic factors selected by Lasso-Cox regression contained tumor number, tumor size, and globulin. The nomogram for high-risk patients showed reliable discrimination, calibration, and clinical utility.
CONCLUSION: This research displayed that the GALAD score is an effective model for predicting the recurrence of HCC. Meanwhile, we found the poor prognosis of the high-risk group and created a nomogram for these patients.
Carbimazole is commenced in a dose of 0.75 mg/kg/day. The intention is to completely prevent endogenous thyroxine production. Thyroxine is then added in a replacement dose as the thyroid hormone levels fall into the lower half of the laboratory normal range. The principal measure of control during the first 6 months will be thyroid hormone levels rather than TSH.
NEW MATERIAL:The redioactive compound of formula I (R is H or lower alkyl; X* is radioactive I or Br; Y is H or halogen; Z is halogen or nitro) or its salt. EXAMPLE:7-Chloro-1-methyl-5-([<125>I]-2-iodophenyl)-3H-1,4-benzodiazep in-2-one. USE:A medicine. A radioactive diagnostic and radioactive drug having directivity to benzodiazepine receptor. It has high affinity to benzodiazepine receptor and is useful also as a radioactive ligand for radioimmunoassay. It can non- invasively detect the presence of benzodiazepine receptor in the brain and other organs or tissues of human, etc., and can dynamically determine the change in the amount of the receptor. PREPARATION:The compound of formula I can be produced e.g. by reacting a benzodiazepine derivative of formula II (X is I or Br) with a radioactive metal iodide or metal bromide such as Na<123>I in a solvent.
The invention discloses lepidium meyenii walp flower healthcare liquor and a preparation method thereof. The lepidium meyenii walp flower healthcare liquor is prepared from, by weight, 100-250 parts of lepidium meyenii walp flowers and 1,000 parts of baijiu. The preparation method comprises the first step of raw material preparation; the second step of baijiu selection, wherein 38-55-degree baijiu is selected; the third step of lepidium meyenii walp flower healthcare liquor preparation, wherein the raw materials obtained in the first step are added into the baijiu in the second step, temperature raising and extracting are carried out, and then, by means of filtering, ageing and filling, the lepidium meyenii walp flower healthcare liquor is obtained. The lepidium meyenii walp flower healthcare liquor is light yellow, clear, transparent, unique in flavor, mild, tasty and slight in irritation and has the effects of resisting fatigue, tonifying middle-jiao and qi, enhancing immunity and the like. The pure natural fragrance is in harmony with the product, the concentration of the active ingredients of the product is greatly improved, and taste and smell are better. The lepidium meyenii walp flower healthcare liquor can play a healthcare role in delaying ageing and prolonging the life after being drunk for a long term.
Previous studies mostly focused on the benefits of caloric restriction and fasting on longevity. However, whether the timing and frequency of eating affect aging remains unclear. Here, we investigated the associations between chrononutrition patterns and biological aging, and explored whether and to what extent dietary inflammation mediated this association. 16 531 adults aged 20 to 84 years from the National Health and Nutrition Examination Survey were collected. Chrononutrition patterns were determined with two 24-hour dietary recalls. Phenotypic age was calculated to reflect the biological aging status. The dietary inflammatory index (DII) was used to assess the dietary inflammation. After adjustment of the survey weight and multiple covariates including total energy intake, participants in the third tertile of the time of the first meal (mean 10 : 26) exhibited more advanced biological age (β 0.64; 95% CI, 0.26-1.00) and a higher incidence of accelerated aging (odds ratio (OR) 1.25; 95% CI, 1.06-1.47) compared to those of the first tertile (mean 6 : 14). Higher eating frequency was associated with delayed biological aging in both multivariable linear (β -0.31; 95% CI, -0.44 to -0.19) and logistic regression model (OR 0.90; 95% CI, 0.85-0.95). Furthermore, we found that DII rather than metabolic factors mediated the inverse association between eating frequency and biological aging (mediation proportion 24.67%; 95% CI, 19.83%-32.00%). Our findings demonstrated the association between chrononutrition patterns and biological aging among the US general population and the potential role of dietary inflammation in this association, suggesting that modifying chrononutrition patterns may be a practical and cost-effective strategy for combating aging.