anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Signs and Symptoms—

Excessive doses of thyroid result in a hypermetabolic state resembling in every respect the condition of endogenous origin. The condition may be self-induced.

Treatment of Overdosage—

Dosage should be reduced or therapy temporarily discontinued if signs and symptoms of overdosage appear.

Treatment may be reinstituted at a lower dosage. In normal individuals, normal hypothalamic-pituitary-thyroid axis function is restored in 6 to 8 weeks after thyroid suppression.

Treatment of acute massive thyroid hormone overdosage is aimed at reducing gastrointestinal absorption of the drugs and counteracting central and peripheral effects, mainly those of increased sympathetic activity. Vomiting may be induced initially if further gastrointestinal absorption can reasonably be prevented and barring contraindications such as coma, convulsions, or loss of the gagging reflex. Treatment is symptomatic and supportive. Oxygen may be administered and ventilation maintained. Cardiac glycosides may be indicated if congestive heart failure develops. Measures to control fever, hypoglycemia, or fluid loss should be instituted if needed. Antiadrenergic agents, particularly propranolol, have been used advantageously in the treatment of increased sympathetic activity. Propranolol may be administered intravenously at a dosage of 1 to 3 mg, over a 10-minute period or orally, 80 to 160 mg/day, initially, especially when no contraindications exist for its use.

Other adjunctive measures may include administration of cholestyramine to interfere with thyroxine absorption, and glucocorticoids to inhibit conversion of T4 to T3.
The present invention relates to an rhBTR gene, an rhBTR gene cloning method, a preparation method of rHBTR gene zymoprotein and a gene probe and application of rHBTR gene zymoprotein and a gene probe. The gene obtain total RNA from fresh human brain tissue. The total RNA is cloned and screened by an RT-PCR method so as to obtain the completel gene, and an expression carrier is constructed through cloning and sequence. An engineering bacterium is led for expressing zymoprotein. The rhBTR gene can be used for preventing and treating degenerative diseases in the nervous system, such as parkinsons disease (PD) and Alzheimer disease (AD). The gene probe prepared by a human brain hioredoxin reductase gene can be widely applied to molecular biology research and clinical detection, and is a diagnosing and researching tool which is widely applied.
Nivolumab 3 mg/kg Q2W + cabiralizumab at the following doses: 1 mg/kg, 2 mg/kg, 4 mg/kg, and 6 mg/kg Q2W. Also nivolumab 3 mg/kg + cabiralizumab 4 mg/kg every 3 weeks (Q3W). Participants with any solid tumor.
FIELD: medicine, therapy, radiobiology. SUBSTANCE: invention proposes a novel agent used for early pathogenetic therapy of radiation damages. The known vasodilator molsidomin (sydnoimine or N-carboxy-3-morpholino-sydnoimine ethyl ester) is used as this agent. Agent can be used by orally route, it shows good tolerance, the presence of tabletting form of drug with prolonged storage. EFFECT: enhanced effectiveness of agent, improved properties. 1 tbl
Patients will be administered Denosumab Q4W at a pre-determine dose for 12 cycles. Denosumab Q4W is administered by subcutaneous injection.
We will apply protocol for 8 weeks 24 Sessions (3 sessions in a week).We will apply protocol for 8 weeks 24 Sessions (3 sessions in a week) and 10 sec rest between each segment, 3 sets of 10 repetitions. Resistive training will start in the form of manual resistive exercise for dorsiflexion, plantar flexion, eversion and inversion (manual resistance was applied for 3 to 5 seconds for ten repetitions in each cardinal plane). Active weight bearing exercises in the form of heel rise and toe rise will performed for ten repetitions each. Towel curl and marble pick up was performed at the end of the session for ten repetitions.
1337461 Storage and distribution of cosmetics P SADA 24 Aug 1971 [11 March 1971] 39652/71 Heading A5B Cosmetics containing two or more natural organic substances are produced, packaged and preserved by mixing the ingredients, deepfreezing them, dividing them either before or after freezing into units each suitable for a single application, packing the units individually under reduced pressure or in the presence of an inert gas and preserving the units in a deep-frozen condition until required for use. Cosmetics specified include anti-freckle lotion and after-shave lotion. Ingredients specified include means to indicate its stability. Before lecithin, lanolin, fennel juice, orange juice, sour cherry juice, strawberry juice, apple juice, peach juice, juice of semi-germinated barley, lymph of cactus plant, live lactic ferments, fresh egg yolk, rose petal gelatin, avocado pulp and royal jelly. The composition may also include means to indicate its stability. Before freezing the composition may be homogenized. Where an enzyme is present, it may be inactivated. The composion may be a sol. It may be packed in an absorbent carrier, e.g. a cotton pad, foam rubber or gauze. The package may be a heat-sealed aluminium envelope.
PURPOSE: This review systematically investigates the role of radiomics in radiotherapy, with a particular emphasis on the use of quantitative imaging biomarkers for predicting clinical outcomes, assessing toxicity, and optimizing treatment planning. While the review encompasses various applications of radiomics in radiotherapy, it particularly highlights its potential for guiding reirradiation of recurrent cancers.
METHODS: A systematic review was conducted based on a Medline search with the search engine PubMed using the keywords "radiomics or radiomic" and "radiotherapy or reirradiation". Out of 189 abstracts reviewed, 147 original articles were included in the analysis. These studies were categorized by tumor localization, imaging modality, study objectives, and performance metrics, with a particular emphasis on the inclusion of external validation and adherence to a standardized radiomics pipeline.
RESULTS: The review identified 14 tumor localizations, with the majority of studies focusing on lung (33 studies), head and neck (27 studies), and brain (15 studies) cancers. CT was the most frequently employed imaging modality (77 studies) for radiomics, followed by MRI (46 studies) and PET (13 studies). The overall AUC across all studies, primarily focused on predicting the risk of recurrence (94 studies) or toxicity (41 studies), was 0.80 (SD=0.08). However, only 24 studies (16.3%) included external validation, with a slightly lower AUC compared to those without it. For studies using CT versus MRI or PET, both had a median AUC of 0.79, with IQRs of 0.73-0.86 for CT and 0.76-0.855 for MRI/PET, showing no significant differences in performance. Five studies involving reirradiation reported a median AUC of 0.81 (IQR: 0.73-0.825).
CONCLUSION: Radiomics demonstrates considerable potential in personalizing radiotherapy by improving treatment precision through better outcome prediction and treatment planning. However, its clinical adoption is hindered by the lack of external validation and variability in study designs. Future research should focus on implementing rigorous validation methods and standardizing imaging protocols to enhance the reliability and generalizability of radiomics in clinical radiotherapy, with particular attention to its application in reirradiation.
RIF: 60mg/kg qd, ATRA: 25mg/m2 qd, till CR. When WBC\>4.0×109/L, patients will be given daunorubicin (20 to 40mg per dose).
A formulation for the topical treatment of joint and/or muscle pain comprising one or more phospholipids and microcapsules containing releasable colourant, wherein the formulation is capable of changing colour upon rupture of the microcapsules. The phospholipids preferably comprise phosphatidylcholine and may be in a nanoemulsion. The colourant is preferably a dye or pigment. The formulation may also contain a further colourant which is different to the colourant in the microcapsules, such that when the microcapsules rupture, the formulation changes from a first colour to a second different colour. The formulation may further comprise an active agent, such as pharmaceutically active ingredients, plant extracts, natural extracts or vitamins. Preferably the formulation comprises a cooling agent such as menthol, or a warming agent such as vanillyl butyl ether and/or methyl salicylate. The formulation may be a gel, cream, lotion, ointment, solution or spray. Also disclosed is a method of treating a patient having joint and/or muscle pain comprising topically applying the formulation to the area of the body affected and massaging the formulation into the skin until the released colour is no longer visible.
FIELD: medicine, pharmacy. SUBSTANCE: solid medicinal formula is made of the cooled granulated melt and has at least one an active component and special additions. Active component is isosorbitol dinitrate or isosorbitol-5-mononitrate. Special additions: structure-forming agent and polymeric thermoplast soluble in the melted active component at temperature from melting point of an active component to decomposition point of its. Polymeric thermoplast is polyvinyl acetate. Method of preparing the solid medicinal formula involves the following stages: mixing an active component and special additions, mixture melting, stirring the melt to the formation of homogeneous mass, granulation and granulate cooling. By the second variant before granulation stage a mixture is extracted in the melt, preferably, at 60-110 C. EFFECT: improved method of preparing, improved quality and property of formula. 10 cl
PURPOSE: A composition containing Gleditsiae Semen ethanol extract and a functional food are provided to suppress lung cancer cell growth and to prevent and treat lung cancer. CONSTITUTION: A composition for preventing and treating lung cancer contains Gleditsiae Semen ethanol extract as an active ingredient. The ethanol extract is prepared by extracting Gleditsiae Semen at 50 Deg. C. for 24 hours and drying and concentrating the extracting at 45 Deg. C. The composition contains pharmaceutically acceptable carriers or diluents. [Reference numerals] (AA) Gleditsiae Semen
Composed by two familiarization sessions, supervised by a Physiotherapist. The protocol include postural reeducation exercises, stretching and muscle strengthening, stabilization and mobilization of the spine. Subsequently, participants will receive an educational booklet containing information on low back pain, anatomy of the spine and its relation to the muscular chain, care during daily life activities and the importance of regular physical exercises. Also, it will include a booklet with the prescription of therapeutic home exercises to be performed during the next 6 weeks. It will be recommended that the participants perform the exercises 2x/week. Participants will also be contacted weekly by email and/or telephone, for remote supervision and for checking the prescribed exercises.
BACKGROUND: Sepsis, a life-threatening condition caused by the dysregulated host response to infection, is a major global health concern. Understanding the impact of viral or bacterial pathogens in sepsis is crucial for improving patient outcomes. This study aimed to investigate the human cytomegalovirus (HCMV) seropositivity as a risk factor for development of sepsis in patients with COVID-19.
METHODS: A multicenter observational study enrolled 95 intensive care patients with COVID-19-induced sepsis and 80 post-surgery individuals as controls. HCMV serostatus was determined using an ELISA test. Comprehensive clinical data, including demographics, comorbidities, and 30-day mortality, were collected. Statistical analyses evaluated the association between HCMV seropositivity and COVID-19 induced sepsis.
RESULTS: The prevalence of HCMV seropositivity did not significantly differ between COVID-19-induced sepsis patients (78%) and controls (71%, p = 0.382) in the entire cohort. However, among patients aged ≤60 years, HCMV seropositivity was significantly higher in COVID-19 sepsis patients compared to controls (86% vs 61%, respectively; p = 0.030). Nevertheless, HCMV serostatus did not affect 30-day survival.
DISCUSSION: These findings confirm the association between HCMV seropositivity and COVID-19 sepsis in non-geriatric patients. However, the lack of an independent effect on 30-day survival can be explained by the cross-reactivity of HCMV specific CD8+ T-cells towards SARS-CoV-2 peptides, which might confer some protection to HCMV seropositive patients. The inclusion of a post-surgery control group strengthens the generalizability of the findings. Further research is needed to elucidate the underlying mechanisms of this association, explore different patient populations, and identify interventions for optimizing patient management.
CONCLUSION: This study validates the association between HCMV seropositivity and severe COVID-19-induced sepsis in non-geriatric patients, contributing to the growing body of evidence on viral pathogens in sepsis. Although HCMV serostatus did not independently influence 30-day survival, future investigations should focus on unraveling the intricate interplay between HCMV, immune responses, and COVID-19. These insights will aid in risk stratification and the development of targeted interventions for viral sepsis.
FIELD: medicine.SUBSTANCE: invention relates to the medicine, namely to the surgery and oncology, and can be used for the inoperable non-small cells lung cancer treatment. For this, performing the diagnostic video thoracoscopy from the affected lung side, the mediastinal pleura fenestration at the anterior mediastinum middle floor level. Next, using the endoscopic instrument, performing the mediastinal pleura peeling out of the underlying pacefollower, starting from the formed fenestra towards the mediastinum upper floor throughout the entire visual controlled area. Formed in the mediastinal pleura fenestra is not sutured. After that, through the formed window, a perforated silicone catheter is installed in the mediastinum, which working part is placed throughout the entire selected pleura, and its distal part is brought to the anterior chest wall surface in the fifth intercostal space along the parasternal line and fixed to the skin. Starting from the 2nd day after the operation, through the installed catheter at the first stage an endolymphatic guide is introduced by drop infusion, which is a glucose-Novocaine mixture in proportions of 100 ml of 5 % glucose and 100 ml of 0.25 % of Novocaine. As the second stage, with an interval of 15 minutes, a solution of cisplatin at a dosage of 50 mg/mis injected through a catheter. Lymphotropic chemotherapy course is carried out daily for 3 days.EFFECT: method enables increase in the lung cancer treatment effectiveness through the use of lymphotropic chemotherapy, ensuring the chemotherapy drug selective delivery to the metastatic lymphatic region and, as a consequence, a decrease in the lymphogenous metastasis frequency.1 cl, 1 ex
The system for automatically dispensing medications or other medical elements includes several vaults (80), each vault containing individual cartridges (138), which each contains packages of unit of use doses of a given medication or other medical supply. Each storage member includes an ejector which ejects selected medications/supplies to a supply trough. The packages in the trough are moved to a central collator (78), which dispenses them to a bin receptacle which has moved underneath the collator and which is identified with a patient. Information concerning medications/supplies for a particular patient is stored in a database and used to determine the particular medications/supplies dispensed into a given bin (28). Bar coding (109) is used to maintain control over the bins. The filled bins are transferred to a medication cart (34) which can only be accessed as a result of a command signal. Overjacketed packages are used to aid dispensing.
A phase I/II, 5 arm, single blind study, comparing five doses of Proellex to matching placebo in healthy adult female subjects of reproductive age. Exposure to study drug will be for up to 10 weeks. In-clinic pharmacokinetic (PK) assessments will be made on the first day of dosing and on the last day (week 10). Office visits will occur every week to assess liver function and trough blood concentrations for Proellex and primary metabolite. Daily vaginal bleeding diaries will be maintained during the course of the study. A single blind run-in period of up to 56 days will begin the study to assess baseline menstrual patterns will be utilized. Twelve subjects per treatment group (total 60 subjects) will be assigned to each dose. New groups will not begin dosing until the previous dose group has completed. Daily treatments will be either 1 mg, 3 mg, 6 mg, 9 mg, 12 mg Proellex. A single blind run-in period using placebo will be incorporated to establish baseline parameters.
Venlafaxine HCl is classified as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) and has been approved by the FDA for the treatment of major depressive disorder. The treatment group will receive a sub-therapeutic dose over a two week period, with a two week titration, starting at 37.5 mg up to a maximum dose of 150 mg per day. At the end of the treatment period, dosage was tapered down in a step-wise fashion over a period of three weeks; 75 mg. for two weeks and 37.5 mg. for one week. While this was the standard protocol, study drug tapering was individualized based on side effects and the clinical judgment of the prescriber.
PURPOSE:To obtain a resin foam which has satisfactorily formed cells of a uniform shape, has a beautiful appearance, and is tough and pliable. CONSTITUTION:This foam is obtained by foaming in an expansion ratio of at least 2, preferably at least 4, a polyethylene resin obtained using as a polymerization catalyst a metallocene compound containing a tetravalent transition metal. The resin preferably has a density of 0.840-0.950g/cm<3> and has a difference of 30 deg.C or smaller between the temp. at which 10wt.% of the resin is eluted in cross fractionation and the temp. at which all the resin is eluted. The resin preferably has a weight-average mol.wt./number-average mol.wt. ratio of 1.5-3.5.
The investigators aim in this study the levels of Visfatin, Vaspin and Omentin secreted from this tissue in pregnant women diagnosed with GDM by oral glucose tolerance test (OGTT) between 24-28 weeks of gestation and to determine if there is a relationship between these parameters. For this purpose, , and 87 pregnant women with gestational diabetes diagnosed at 24-28 weeks from the same patient group will be included in the study. . The same number of non-GDM control group pregnant women will also be included in the study at 24-28 weeks. Age, gestational week, pregnancy history (gravida, parity, abortion, missed, ectopic), medical history, preconceptional BMI, current BMI, triglyceride, VLDL, HDL, LDL, cholesterol, HOMA-IR, C-peptide, insulin, Hba1c levels will be saved. In the 2nd trimester, between 24-26 weeks, OGTT will be performed on the patients and the results will be recorded. Visfatin, Vaspin and Omentin levels will be checked and recorded in patients diagnosed with GDM.
The invention belongs to the medicine field, specifically relates to compound isatis root puffed granules and a preparation method of the same. A technical problem to be solved in the invention is to provide spheroidic compound isatis root puffed granules with a smooth and compact shape and good fluidity. Extraction or decoction technology in a granulation process can be performed with reference to the prior art. A main difference between the preparation method and the prior art is to make granules into a state of compression. In a granule drying stage, a moisture content is firstly controlled in the range of from 4% to 5% by low temperature control, then the granules are heated and puffed under a high temperature condition, the obtained product is dried and granulated. The preparation method of the invention can form spherical or spheroidic granules with the smooth and compact shape. Cavitation and puffing phenomenon can be seen inside the granules. The granules are not easy to break into pieces and are in a good shape; the angle of repose of the granules is in the range of from 10 DEG to 25 DEG, the granules are of good fluidity and are not easy to absorb moisture. The dosage of auxiliary materials is low. A cream-shaped material is not easy to appear when the granules are mixed with water, and the granules are easy to be mixed with water. The compound isatis root puffed granules of the invention can also be used as raw materials to prepare tablets or capsules by tabletting or capsulation according to the conventional art.
The teleost Astyanax mexicanus consists of surface dwelling (surface fish) and cave dwelling (cavefish) forms. Cavefish have evolved in subterranean habitats characterized by reduced oxygen levels (hypoxia) and exhibit a subset of phenotypic traits controlled by increased Sonic hedgehog (Shh) signaling along the embryonic midline. The enhancement of primitive hematopoietic domains, which are formed bilaterally in the anterior and posterior lateral plate mesoderm, are responsible for the development of more larval erythrocytes in cavefish relative to surface fish. In this study, we determine the role of hypoxia and Shh signaling in the development and evolution of primitive hematopoiesis in cavefish. We show that hypoxia treatment during embryogenesis increases primitive hematopoiesis and erythrocyte development in surface fish. We also demonstrate that upregulation of Shh midline signaling by the Smoothened agonist SAG increases primitive hematopoiesis and erythrocyte development in surface fish, whereas Shh downregulation via treatment with the Smoothened inhibitor cyclopamine decreases these traits in cavefish. Together these results suggest that hematopoietic enhancement is regulated by hypoxia and Shh signaling. Lastly, we demonstrate that hypoxia enhances expression of Shh signaling along the midline of surface fish embryos. We conclude that hypoxia-mediated Shh plasticity may be a driving force for the adaptive evolution of primitive hematopoiesis and erythrocyte development in cavefish.
PURPOSE: The purpose of this study was to investigate the relations between functional hearing, language, social, bilateral coordination and manual dexterity skills in children with early cochlear implants (CIs).
METHODS: Thirty children with CIs were included in this study. The manual dexterity and bilateral coordination development of the participants were evaluated with Manual Dexterity and Bilateral Coordination subtests of Bruininks-Oseretsky Motor Proficiency-2 (BOT-2). Their language skills were assessed by the Test of Early language Development-3. To assess the functional hearing of participants the Functioning After Pediatric Cochlear Implantation scale (FAPCI) was administered their caregivers. Also, the Social Skills Evaluation Scale was administered to participants' teachers to asses their social skills.
RESULTS: There were significant correlations between participants' receptive and expressive language skills, Manual Dexterity, and FAPCI scores (p < 0.05). There were also significant relationships between the SSES and FAPCI scores of the participants (p < 0.05). However, the Bilateral Coordination subtest did not show any significant correlation with any of the measurements (p > 0.05).
CONCLUSION: The results suggest that the language, manual dexterity and functional hearing abilities of children with CIs are closely related. Although, there were no significant correlations between all of the measurement, it is important to look beyond hearing and speech evaluations to assess the whole child.
Complex Decongestive Treatment (manual lymph drainage, skin care, special exercises, compression) approach. It will be applied 5 days a week for 3 weeks.