anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment.
METHODS: We examined the relationship between genetically determined levels of plasma proteins and PC through a systemic proteome-wide Mendelian randomization (MR) analysis utilizing cis-pQTLs from multiple centers. Rigorous sensitivity analyses, colocalization, reverse MR, replications with varying instrumental variable selections and additional datasets, as well as subsequent meta-analysis, were utilized to confirm the robustness of significant findings. The causative effect of corresponding protein-coding genes' expression and their expression pattern in single-cell types were then investigated. Enrichment analysis, between-protein interaction and causation, knock-out mice models, and mediation analysis with established PC risk factors were applied to indicate the pathogenetic pathways. These candidate targets were ultimately prioritized upon druggability and potential side effects predicted by a phenome-wide MR.
RESULTS: Twenty-one PC-related circulating proteins were identified in the exploratory phase with no evidence for horizontal pleiotropy or reverse causation. Of these, 11 were confirmed in a meta-analysis integrating external validations. The causality at a transcription level was repeated for neutrophil elastase, hydroxyacylglutathione hydrolase, lipase member N, protein disulfide-isomerase A5, xyloside xylosyltransferase 1. The carbohydrate sulfotransferase 11 and histo-blood group ABO system transferase exhibited high-support genetic colocalization evidence and were found to affect PC carcinogenesis partially through modulating body mass index and type 2 diabetes, respectively. Approved drugs have been established for eight candidate targets, which could potentially be repurposed for PC therapies. The phenome-wide investigation revealed 12 proteins associated with 51 non-PC traits, and interference on protein disulfide-isomerase A5 and cystatin-D would increase the risk of other malignancies.
CONCLUSIONS: By employing comprehensive methodologies, this study demonstrated a genetic predisposition linking 21 circulating proteins to PC risk. Our findings shed new light on the PC etiology and highlighted potential targets as priorities for future efforts in early diagnosis and therapeutic strategies of PC.
This was a group of 8 junior high school students who received conventional school-based Occupational Therapy service for handwriting difficulty during the 2012-13 School Year. The participants received a like fitness exercises, fine motor speed training, and handwriting practice on their dominant hand instead.
MIRAPEX tablets for treatment of RLS have been evaluated for safety in 889 patients, including 427 treated for over six months and 75 for over one year. 

The overall safety assessment focuses on the results of three double-blind, placebo-controlled trials, in which 575 patients with RLS were treated with MIRAPEX tablets for up to 12 weeks. The most commonly observed adverse events with MIRAPEX tablets in the treatment of RLS (observed in > 5% of pramipexole-treated patients and at a rate at least twice that observed in placebo-treated patients) were nausea and somnolence. Occurrences of nausea and somnolence in clinical trials were generally mild and transient.

Approximately 7% of 575 patients treated with MIRAPEX tablets during the double-blind periods of three placebo-controlled trials discontinued treatment due to adverse events compared to 5% of 223 patients who received placebo. The adverse event most commonly causing discontinuation of treatment was nausea (1%).

Table 5 lists treatment-emergent events that occurred in three double-blind, placebo-controlled studies in RLS patients that were reported by ≥ 2% of patients treated with MIRAPEX tablets and were numerically more frequent than in the placebo group. 

The prescriber should be aware that these figures cannot be used to predict the incidence of adverse events in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical studies. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. However, the cited figures do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the adverse-event incidence rate in the population studied.

Other events reported by 2% or more of RLS patients treated with Mirapex® (pramipexole dihydrochloride) tablets but equally or more frequently in the placebo group, were: vomiting, nasopharyngitis, back pain, pain in extremity, dizziness, and insomnia.

Table 6 summarizes data for adverse events that appeared to be dose related in the 12-week fixed dose study.
<P>PROBLEM TO BE SOLVED: To provide a food or a medicine taken daily and continuously, and exhibiting safe and sufficient antiallergic effects.  <P>SOLUTION: The antiallergic agent contains an extract of a leaf of olive and an extract of oolong stem tea. A commercial product can be utilized as the extract of the leaf of the olive. The dietary intake of the extract of the leaf of the olive and the extract of the oolong stem tea is different based on the shape, symptom, age, body weight or the like, but the intake of the extract of the leaf of the olive is 1-1,000 mg/day, preferably, 5-200 mg/day, and the intake of the oolong stem tea is 1-1,000 mg/day, preferably 5-500 mg/day. The dose form of the allergic agent is unlimited, and a normal form of a food and a medicine such as a tablet sweet, a candy, a granule and a beverage can be adopted.  <P>COPYRIGHT: (C)2007,JPO&INPIT
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology and reconstructive surgery. Through an arc-shaped incision up to 40 mm along the contour of the nipple-areolar complex, a skin-preserving mastectomy with layer wound suturing is performed. At the next stage through a separate armpit access, regional lymphodiscussion with the installation of active drainage and wound suturing is performed. Skin incision up to 1.5 mm is made along the submammar fold, with a 0.9 % sodium chloride solution up to 150 ml administrated through a special cannula for lipofilling, checking the tightness of the formed cavity. At the next stage through the cannula, adipose tissue from the donor zones is introduced by 30 % more volume of the removed tissue of the glandula mammaria. In the postoperative period for the next 5 days, the patient is hyperbaric oxygenated at a pressure of 1.3 atmospheres for 30 minutes daily.EFFECT: method provides reduced frequency of postoperative complications, increased therapeutic efficiency of reconstruction, static and dynamic symmetry at a small volume of the glandula mammaria, reduced number of hospitalizations to achieve a final aesthetic result and reduced economic costs of treatment.1 cl, 1 ex, 2 dwg
PURPOSE: To obtain a safe carotenoid stable for a long period without emitting a malodor and causing any side effects by blending a lutein which is one kind of inexpensive and safe carotenoid therein. CONSTITUTION: This cosmetic is an inexpensive and safe cosmetic without emitting malodor and obtained by blending a lutein or a natural extract containing the lutein therein. One kind selected from a natural substance containing the lutein, an extract containing the lutein, synthetic lutein, an ester derivative of the lutein and a combination of a protein with the lutein or a mixture of two or more thereof is preferred as the lutein. Since five kinds of luteins A, B, D, F and G in the lutein are abundantly present in the natural world, extraction is readily carried out for easy utilization thereof. The lutein derived from the natural product is abundantly present in the chloroplast or a flower of higher plants such as a marigold and egg yolk, etc., of animals such as a hen's egg.  A fatty acid ester of the lutein and the combination of the protein with the lutein can be used as the lutein. Furthermore, the usable dosage form of the cosmetic is a cream, a milky lotion, toilet water, a mousse, a pack, a lipstick, a foundation, etc.
BACKGROUND: To compare and analyze clinical characteristics of patients undergoing two surgeries and multiple surgeries and explore relevant factors to lay the foundation for clinical prediction.
METHODS: A retrospective analysis was conducted on clinical data from all patients who underwent twice and multiple strabismus surgeries at Tianjin Eye Hospital between October 2012 and September 2021. Patients were divided into Group A (two surgeries) and Group B (more than two surgeries) based on the cumulative number of surgeries performed. Clinical details at the first recurrence, including sex, age, native place, overall medical history, onset time, visual acuity, affected muscle(s), etc., were documented. Non-parametric tests and chi-square tests were used to analyze clinical characteristics in each group. Binary and ordered logistic regression analysis assessed parameters associated with multiple reoperations. A linear mixed-term model observed factors impacting affected muscle(s) during surgery. Researchers examined clinical traits related to secondary strabismus variables.
RESULTS: Among the 910 included patients, 840 required two surgeries (Group A) and 70 underwent more than two surgeries (Group B). Significant differences were found in age, onset time, interval time, and secondary factors. Regression analysis highlighted the significant impact of interval time on the reoperation rate, effectively predicting outcomes in patients with concomitant strabismus. Other ophthalmoplegia and secondary factors significantly influenced reoperation rates in patients with non-concomitant strabismus. Interval time, esotropia, and exotropia were linked to concomitant secondary strabismus patients, while the number of surgeries, DVD, esotropia, exotropia, and esotropia V-pattern were associated with non-concomitant secondary strabismus patients. In a longitudinal study, patients with multiple surgeries showed a correlation between the vertical deviation angle magnitude and the number of involved extraocular muscles. Regression analysis revealed that in patients with concomitant strabismus, interval time, exotropia, and esotropia influenced the total number of muscles during surgery. For patients with non-concomitant strabismus, interval time, secondary factors, and SOP impacted the total number of muscles during surgery.
CONCLUSIONS: Interval time in patients with concomitant strabismus, as well as secondary and other ophthalmoplegia in non-concomitant strabismus, are the main factors for multiple reoperations.
In follow-up study, no medication or investigational product was administered. In base study P05690 (NCT00702845), participants in the reference group received a single SC injection of placebo-corifollitropin alfa administered on Day 2 or 3 of the menstrual cycle and daily SC recFSH 150 IU injections (7 total) from Stimulation Day 1 up to and including Stimulation Day 7. Participants also received open-label recFSH (up to 200 IU/day) from Stimulation Day 8 onwards, up to and including Day of hCG (10,000 or 5,000 IU/USP) administration. Participants also received the GnRH antagonist ganirelix (0.25 mg) once daily SC starting on Stimulation Day 5 up to and including the Day of hCG. Participants also received progesterone (at least 600 mg/day vaginally or 50 mg/day IM), starting on the day of OPU and continuing for at least 6 weeks or up to menses.
Bone resorption and sinus pneumatization, following tooth extraction, are common occurrences in the posterior maxilla. They may cause both a quantitative reduction and qualitative deterioration of bone, resulting in an inadequate bone volume for a standard implant placement. Sinus floor elevation with lateral approach had been described 35 years ago and widely studied afterwards, demonstrating an high predictability in regenerating bone, to allow for reliable implant supported rehabilitations. Maxillary sinus floor elevation with transcrestal approach represents a validated and effective alternative option to vertically enhance the available bone through an access created in the edentulous bone crest. Regardless of graft type, it is not yet well defined how three-dimensional anatomical sinus cavity characteristics may influence healing and mineralization process. An adequate Schneiderian membrane elevation in order to expose sinus floor, buccal and medial walls, seems to represent a crucial factor in influencing new bone formation, as the greatest part of the osteoprogenitor cells derives from these anatomical structures. It is not documented yet the efficacy of the different trnanscrestal sinus floor elevation approaches in exposing the internal bony walls of the sinus. Moreover, on the basis of the fact that only few articles correlated the size of the maxillary sinus with histologic outcome by lateral window and one retrospective radiographic study reported results in relation to the three-dimensional conformation of the sinus using a trans-crestal approach, the investigators conjecture that sinus bucco-palatal diameter could influence the newly-formed bone quality after a crestal sinus lift procedure. For example, the healing in a narrow maxillary sinus could result in a faster new bone formation, when compared to a larger and wider sinus. The aim of this study is to analyze neoformed bone after maxillary sinus lifting with transcrestal approach, in atrophic crests (≤5 mm residual bone height). Clinical and laboratory data will be related to maxillo breast anatomy. The present study has been designed as a multicenter prospective clinical trial. Five clinical centers will treat patients with two-stage transcrestal sinus floor elevation using a calibrated drills technique and a xenogeneic biomaterial. Implants will be inserted 6 months after sinus augmentation and bone-core biopsies will be harvested during the implant site preparation. Histological analyses will be performed in order to assess the quality of the newly-formed tissue and cone beam computed tomography scan examination will be used to evaluate graft resorption over time. For each inserted implant, collection of experimental parameters will be required up to 1 year after its placement.
PROBLEM TO BE SOLVED: To obtain the subject prophylactic agent or therapeutic agent capable of increasing leukocytes which are granulocytes-macrophages and effective in improving leukopenia by including a parathyroid hormone (derivative) as an active ingredient therein. SOLUTION: This prophylactic or therapeutic agent is obtained by including at least one kind of parathyroid hormone(PTH) (derivative) as an active ingredient. Human PTH (1-84), human PTH (1-34), etc. are preferably used as the PTH or PTH derivative. The prophylactic or therapeutic agent is useful for the prophylaxis and therapy of bacteria, virus, rickettsia and protozoan infection, hemodyscrasia such as hypoplastic anemia, osteomyelodysplasia syndrome or leukemia, immunological abnormality such as spleen hyperfunction or systemic lupus erythematosus and leukopenia caused by radiation exposure or an agent and a chemical substance, etc. such as an antibiotic, an antipyretic and analgesic agent, an antithyroid agent or an antitumor agent besides leukopenia caused by congenital diseases.
In early 2020, a global pandemic was announced due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known to cause COVID-19. Despite worldwide efforts, there are only limited options regarding antiviral drug treatments for COVID-19. Although vaccines are now available, issues such as declining efficacy against different SARS-CoV-2 variants and the aging of vaccine-induced immunity highlight the importance of finding more antiviral drugs as a second line of defense against the disease. Drug repurposing has been used to rapidly find COVID-19 therapeutic options. Due to the lack of clinical evidence for the therapeutic benefits and certain serious side effects of repurposed antivirals, the search for an antiviral drug against SARS-CoV-2 with fewer side effects continues. In recent years, numerous studies have included antiviral chemicals from a variety of plant species. A better knowledge of the possible antiviral natural products and their mechanism against SARS-CoV-2 will help to develop stronger and more targeted direct-acting antiviral agents. The aim of the present study was to compile the current data on potential plant metabolites that can be investigated in COVID-19 drug discovery and development. This review represents a collection of plant secondary metabolites and their mode of action against SARS-CoV and SARS-CoV-2.
The invention discloses a BCMA single domain antibody and a BCMA-CAR-T cell as well as preparation and application thereof. Specifically disclosed are single domain antibodies that specifically target BCMA and chimeric antigen receptors (SEQ id No. 1) containing the single domain antibodies. The invention also discloses a CAR-T cell (BCMA-VHH CAR-T cell) containing the chimeric antigen receptor. Experiments prove that BCMA-VHH CAR-T cells can well secrete T cell specific effector molecules IFN-gamma, and effectively and specifically kill BCMA  +  The target cells have good in-vivo tumor killing activity, can obviously inhibit proliferation of tumor cells in mice, and can also obviously prolong survival time of the mice. The BCMA-VHH CAR-T cell has good anti-tumor capability, can be used for the immunotherapy of diseases related to BCMA targets, and has wide clinical application prospect.
The invention discloses a formula of five-ingredient health medicinal liquor with effects of promoting appetite and rectifying qi. The formula is designed according to the principle of synergism of drugs and wine. The formula comprises 25-35g of clove, 25-35g of sandalwood, 35-45g of costusroot, 35-45g of fructus amomi and 90-110ml of honey. A preparation method of the five-ingredient health medicinal liquor comprises cleaning four Chinese herbal medicines, airing the Chinese herbal medicines, grinding the Chinese herbal medicines to obtain powder, putting the powder and honey into a bag prepared from three layers of gauze through sewing, tightening the opening of the bag, immersing the bag in a jar with 2000ml of liquor, sealing the jar, boiling the medicinal liquor through a mild fire for about 1h, opening the jar after two weeks, taking out the drug bag and filtering to remove impurities to obtain the medicinal liquor for drinking. An adult can drink about 20ml of the warm medicinal liquor before a meal every day. The five-ingredient health medicinal liquor has effects of tonifying spleen and promoting appetite, regulating qi and stopping bleeding, and improving appetite and can treat spleen and stomach discomfort, inappetence and abdominal swelling pain.
Japanese encephalitis virus (JEV) is an orthoflavivirus that causes Japanese encephalitis, a mosquito-borne viral infection that primarily affects humans and animals. JEV is a major cause of encephalitis in many parts of Asia, particularly in rural and agricultural areas. In this study, we used the IFNAR1-/- mice model to investigate alterations in cytokine and apoptotic factor levels in IFNAR1-/- mice upon JEV infection. A 5-week-adult female C57BL/6 IFN-α/β receptor knockout (IFNAR1-/-) transgenic mice were intramuscularly inoculated with several viral titers and monitored within 10 dpi. The weight changes and survival rates were evaluated during the study period. Gene expression analysis was performed using RT-qPCR, targeting genes related to specific cytokines and apoptotic factors, to identify the inflammatory factors fluctuations associated with JEV strain KBPV-VR-27 infection in IFNAR1-/- mice. The expression of cytokine genes was enhanced in IFNAR1-/- mice infected with JEV KBPV-VR-27. Notably, a significant induction of cytokines, such as IL-13, IL-17α, IFN-β, and IFN-γ, was observed in the brain, while upregulation of IL-6, IFN-β, and IFN-γ was exhibited in the lung. In addition, among the targeted apoptotic factors, only significant induction of Bak was observed in the brain. We also found that the spleen exhibited a higher viral load compared to the brain and lungs. In conclusion, the findings of this study shed light on the varying viral loads across targeted organs, with the brain exhibiting a lower viral load but pronounced expression of targeted pro-inflammatory cytokines in IFNAR1-/- mice.
Aneurysm of sinus Valsalva is a defined as dilatation of the sinuses located between the aortic valve annulus and the sinotubular junction and mostly found in the right coronary sinus. It can be either congenital or acquired. This condition is usually asymptomatic unless it can cause intracardiac rupture or aortic valve insufficiency. Extracardiac rupture and associated fatal cases of cardiac tamponade are extremely rare. Our case is one of the rare cases in the literature that was diagnosed during autopsy. Our case is 65-year-old male patient with a history of hypertension suddenly fell ill after swimming in the sea. On gross examination of heart, there was an aneurysmatic enlargement of the right sinus Valsalva measuring 4.5 × 4 cm with a hemorrhagic appearance on the outer surface and a 0.3 cm rupture area. Histopathological examination revealed hemorrhage in and around the aneurysm wall.
Virus present in semen likely contributes substantially to the sexual transmission of HIV. However, the source of HIV in semen is unknown. Some evidence suggests that the prostate may be the source of at least some of the virus in semen. This study is designed to determine whether the prostate may serve as the source of virus in semen by comparing the concentration of HIV-1 RNA in semen donated normally, in semen obtained following prostatic massage, and in expressed prostatic secretions. Finding a source for semen HIV would provide important insights into several aspects of HIV sexual transmission. Since some drugs do not enter the prostate well, the finding that virus is produced in the prostate might suggest the prostate could serve as a reservoir for HIV, leading to the development of resistance to antiviral agents.