anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Endoscopic ultrasonography (EUS) provides high spatial resolution and more detailed images than other diagnostic modalities. Furthermore, EUS-guided tissue acquisition (EUS-TA), such as EUS-guided fine needle aspiration or biopsy (EUS-FNA/FNB), is an indispensable tool in pancreaticobiliary disease diagnostics, supporting a conclusive pathological diagnosis. In this review, we evaluate the current status and the usefulness of EUS-TA for the diagnostics of the following biliary tract diseases: (A) biliary stricture diagnostics, (B) biliary tract cancer (BTC) itself, and (C) staging of advanced BTC. Previous reports have shown that EUS-FNA for biliary lesions is a safe procedure that is useful in differentiating biliary cancer from benign lesions and in the staging of BTC. On the other hand, the diagnostic performance of EUS-TA for bile duct lesions is reported to be similar to that of transpapillary biopsy. Overall, EUS-TA for biliary lesions may be a safe and effective method, but it should be performed with an understanding of the risk of serious adverse events such as bile leakage and peritoneal dissemination of cancer. It is recommended for distal biliary stricture lesions for which endoscopic retrograde cholangiopancreatography cannot confirm the diagnosis or gallbladder lesions if they do not require the needle to pass through the biliary lumen.
Anxiety is the most common mental health problem in youth, affecting one in four children and adolescents. Unfortunately, evidence-based treatments (pharmacotherapy, cognitive-behavioral therapy) are costly, not widely available, and ineffective for a substantial proportion of youth. In response, experts have called for novel treatments that directly target mechanisms underlying youth anxiety while simultaneously addressing barriers to care (i.e., cost, accessibility). One such promising mechanism is interpretation bias - the inaccurate interpretation of threat from ambiguity. The investigators have previously demonstrated that interpretation bias occurs in over 90% of anxious youth, is predictive of anxiety severity in clinical samples of youth, and differentiates between anxious and non-anxious youth. These data indicate that interpretation bias may be a ubiquitous phenomenon underlying anxiety expression in children and adolescents and therefore may be an ideal intervention target. Cognitive bias modification for interpretation bias (CBM-I) is a computerized intervention that attempts to reduce anxiety by directly modifying interpretation bias. CBM-I has demonstrated preliminary efficacy for reducing anxiety symptoms in adults. Yet extant CBM-I data in anxious youth are sparse, with little work addressing whether CBM-I significantly reduces interpretation bias, and whether this in turn reduces anxiety symptoms, as well as the dose necessary to reduce both bias and anxiety. This two-phased study tests personalized CBM-I in youth ages 10 to 17 who meet diagnostic criteria for a primary anxiety disorder (Separation, Social, Generalized). In the R61 Phase (N=46), a randomized clinical trial (RCT) examines whether CBM-I personalized to youth anxiety symptoms significantly reduces interpretation bias compared to a computerized interpretation control condition (ICC). The interpretation target will be measured at multiple time points (4, 8, 12, 16 sessions) to identify the optimal dose for reduction in interpretation bias. If the R61 trial results indicate that CBM-I outperforms ICC on interpretation bias reduction, the R33 phase will commence. In the R33 Phase, an RCT (N=72) will validate whether CBM-I significantly reduces interpretation bias, and conducts a mechanism test (i.e., does bias reduction precede and predict anxiety reduction?), by comparing CBM-I to cognitive restructuring, a clinically relevant psychosocial intervention that also targets anxious cognition.
BACKGROUND: Musculoskeletal (MSK) spinal pain encapsulates various conditions including lumbar (low back), cervical (neck), and thoracic pain that significantly impact individual and global health. While clinical aspects of spinal pain have been well-studied, understanding patients' personal narratives and lived experiences remains essential for enhancing patient-centered care, improving treatment adherence, and informing healthcare policies. It provides deep insights into the impacts of spinal pain, guiding more effective and empathetic treatment approaches. This systematic review aims to synthesize qualitative evidence on patients' experiences with MSK spinal pain, providing insight into the challenges faced, coping strategies, daily life impacts, and healthcare interactions. The objective of this review is to synthesize the qualitative evidence regarding the lived experiences of patients with MSK spinal pain.
METHODS: This systematic review will use a meta-aggregation approach to synthesize data from qualitative studies, that will be identified through a comprehensive search of electronic databases and supplemented by grey literature searches. Two independent reviewers will screen, identify, and extract data from eligible studies. In cases of disagreement, conflicts will be resolved by consulting a third reviewer. These same reviewers will then use the Joanna Briggs Institute (JBI) qualitative quality assessment tool to evaluate the methodological quality of the identified studies, with the derived scores informing the synthesis process, that will involve extracting each study's findings along with their supporting illustrations, then grouped into categories based on similarity in meaning. These categories will then be aggregated to form synthesized findings.
IMPLICATIONS: Synthesized findings on patients' lived experiences with MSK spinal pain including key themes, patterns, and insights will be presented. By emphasizing patient narratives, the results of the review can contribute to the optimization of outcomes, and to enhance patient-provider relations and improve quality of care in MSK spinal health.
PURPOSE:To collect an effective raw material for drug or for cosmetic from leaves of a Japanese cypress simply. CONSTITUTION:A Japanese cypress taking root on the ground is cut down and leaves of the tree are collected. The collected leaves are transported as rapidly as possible and powdered by a grinder before change in quality of the leaves occurs. The powder is immersed in water as rapidly as possible or the collected leaves together with water are fed to the grinder to prevent vaporization of a volatile component from the powder and the powder and water are fed to a pot. When the powder is boiled, a flesh part of the leaves is eluted in water to give a viscous solution and a medicinal and cosmetic component is contained in the viscous solution as a carrier. After the boiling process is over, an eluate is separated from the residue so that the leaves are treated. The viscous solution has antimicrobial power, exhibits controlling action and effects on the skin as an anti-inflammatory agent, analeptic, etc., shows action of an irritant or diuretic by drinking it and can be used as delayed release insecticide for agriculture, chemical pack, etc.
Resuscitation will be initiated at 30% O2. Titration of oxygen during neonatal resuscitation: Intervention is target goal saturations which will be the 75th percentile saturations observed in healthy term newborns.
PURPOSE:To obtain the title composition curable in an approximately neutral condition, outstanding in affinity for the teeth, bone etc., thus applicable to the dentistry, orthopedics or the like, by incorporating an acidic aqueous solution of chitosan with hydroxyapatite, zinc oxide etc. CONSTITUTION:Firstly, 2-40 (pref. 3-30)wt.% of chitosan is dissolved in an aqueous acid (e.g., malic acid) solution (the amount of said acid is pref. 50-100 pts.wt. based on 100 pts.wt. of chitosan). For said acidic aqueous solution, a physiological salt solution or Ringer solution may also be used. Thence, this solution is incorporated with hydroxyapatite and zinc oxide and/or magnesium oxide into the objective curable composition. The weight ratio of the hydroxyapatite to the metallic oxide(s) is 60-99/1-40 (pref. 80-99/1-20). The weight ratio of the acidic aqueous solution of chitosan to the above-mentioned powder is normally 100/30-250.
This is an observational prospective cohort study of confirmed cases of COVID-19 recruited from communities surrounding New York City. 325 participants will be recruited from NewYork-Presbyterian (NYP)-Columbia hospital, the community using flyers and snowball sampling, and by contacting participants who are already participating in a Columbia University Irving Medical Center (CUIMC) COVID-19 related study and have given consent to be contacted about participation in related research studies. Candidates will be eligible to participate if they have received a laboratory confirmed diagnosis of COVID-19 or were symptomatic and had a known contact with a confirmed case of COVID-19, and are over the age of 7. Participants who were diagnosed empirically due to symptoms and exposure yet test negative by Reverse transcription polymerase chain reaction (RT-PCR) and serology at baseline will not be considered infected with SARS-CoV-2 and may be excluded. Participants will be consented prior to participation in any study activities and will be prospectively followed for 96 weeks. At baseline, an enrollment survey will be administered that includes demographics, comorbidities, and characteristics of their COVID-19 illness (e.g., exposure, symptom onset, symptom duration, severity of symptoms) and will provide blood and host reservoir site samples. Participants will be followed for a 24 month period after symptom onset, with a maximum of 12 visits.
Processed red ginseng are non-toxic and healthy "tonics". It was recorded in medical books and Materia Medica that taking it for a long time can prolong life. The main purpose of this study is to evaluate the effect of ginseng on antioxidation and healthy aging indicators of sub-health subjects in Han Chinese population. Subjects will undergo a safety follow-up after the treatment period. Safety and efficacy will be determined by looking at a number of assessments \[physical examinations, blood sampling, hearing sub-health status evaluation questionnaire (shsq-25), etc.\]. It is expected that around 900 people (at least 450 in each arm) with sub-healthy state may take part in the study. The study participants will be recruited at around 3 sites from Shanghai, Beijing and Foshan, in China.
PROBLEM TO BE SOLVED: To obtain a new compound useful as a fluorescent whitening agent, esp. capable of giving textile fibrous materials high-level whiteness and high sunlight screening effect. SOLUTION: This new compound is shown by formula I [m is a cation formed from H, an alkali metal, ammonium or amine; R1 is a group of formula II (R3 is NR4 R5 , etc.; R4 an R5 are each H, a 1-20C alkyl, atc.), etc.; R2 is NH2 , N(CH2 CH2 OH)2 , etc.], e.g. a compound of formula III. The compound of formula I is obtained by reaction of cyanuric chloride with aminostilbenesulfonic acid, an amino compound capable of introducing R1 group, and a compound capable of introducing R2 group, respectively, in any order, under well-known conditions. The compound of formula I is capable of absorbing both UV-A and UV-B ultraviolet rays, giving textile fibrous materials such as cotton, polyamide and wool fluorescent whitening effect, and affording sunscreening protection of the skin covered with a textile product treated with this compound.  Besides, the tear strength and light fastness of textile fibrous materials treated with this compound can also be improved.
Peripheral venous catheter is applied under aseptic conditions. In order to easily see whether phlebitis occurs in the catheter area, the area where the catheter is inserted is covered with a Tegaderm transparent film cover and the catheter is fixed. No oil application will be made. The patients in all groups will be evaluated with the GIFTS scale for phlebitis every hour for the first 25 hours from the time of opening the catheter, and every 6 hours for the next 48 hours.
<P>PROBLEM TO BE SOLVED: To provide an antiinflammatory agent, a beautifying and whitening agent, or an anti-ageing agent comprising extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae, and a skin cosmetic comprising these.  <P>SOLUTION: The antiinflammatory agent comprises extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The beautifying and whitening agent comprises the extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The anti-ageing agent comprises the extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The skin cosmetic comprises as effective ingredients extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The invention discloses a recombinant protein PACAP38-NtA, and a coding gene and application thereof. The amino acid sequence of the recombinant protein PACAP38-NtA is disclosed as SEQ ID NO.1. The nucleotide sequence for coding the recombinant protein PACAP38-NtA is disclosed as SEQ ID NO.2. The nucleotide sequence disclosed as SEQ ID NO.2 is cloned into a prokaryotic expression vector pET-3c, and transfected into Escherichia coli BL21(DE3) to obtain the expression recombinant protein PACAP38-NtA strain. According to the invention, a minitype bioreactor is utilized to ferment the strain, and a two-step purification method comprising common ion-exchange chromatography and nickel-column affinity chromatography, which is simple to operate, is utilized to obtain the high-purity target protein. The obtained recombinant PACAP38-NtA fusion protein can be specifically combined with laminin, can effectively promote proliferation and differentiation of neuron-like cells PC12, and can enhance the restorability of the injured part when acting on the mouse corneal scratched part; and the recombinant PACAP38-NtA fusion protein can be can be used for preparing medicines for restoring corneal injuries.
INTRODUCTION: Two-stage exchange is the gold standard in the surgical management of prosthetic joint infection (PJI). However, perioperative reinfections (RePJI) can occur to newly inserted prosthesis, which highlights the importance of an adequate antibiotic prophylaxis, although there is scarce evidence in this field. Our objective was to evaluate the characteristics of RePJI, its prognosis and the antibiotic prophylaxis that is commonly used in second-stage surgery.
METHODS: Multicentric retrospective observational study in Spanish hospitals including patients with RePJI between 2009 and 2018.
RESULTS: We included 92 patients with RePJI from 12 hospitals. The most frequent isolated microorganism was Staphylococcus epidermidis in 35 cases (38.5%); 61.1% of staphylococci were methiciliin-resistant. In 12 cases (13%), the same microoganism causing the primary PJI was isolated in RePJI. When comparing with the microbiology of primary PJI, there were more cases caused by Gram-negative bacteria (the most frequent was Pseudomonas spp.) and less by Gram-positive bacteria. Failure occured in 69 cases (75%). There were 43 different courses of antibiotic prophylaxis after the second-stage surgery; the most frequent was a unique preoperative cefazolin dose, but most patients received prophylaxis before and after the second-stage surgery (61 cases).
CONCLUSIONS: The most frequent microorganisms in RePJI are coagulase-negative staphylococci, although Gram-negative bacteria, especially Pseudomonas spp. are also common. There is a significant heterogeneity in antibiotic prophylaxis for a second-stage surgery. ReIPJI treatment has a high failure rate.
As a famous prescription in China, AnGong NiuHuang (AGNH) pill exerts good neuroprotection for ischaemic stroke (IS), but its mechanism is still unclear. In this study, the neuroprotection of AGNH was evaluated in the rat IS model which were established with the surgery of middle cerebral artery occlusion (MCAO), and the potential mechanism was elucidated by transcriptomic analysis and metabolomic analysis. AGNH treatment obviously decreased the infarct volume and Zea-Longa 5-point neurological deficit scores, improved the survival percentage of rats, regional cerebral blood flow (rCBF), and rat activity distance and activity time. Transcriptomics showed that AGNH exerted its anti-inflammatory effects by affecting the regulatory network including Tyrobp, Syk, Tlr2, Myd88 and Ccl2 as the core. Integrating transcriptomics and metabolomics identified 8 key metabolites regulated by AGNH, including L-histidine, L-serine, L-alanine, fumaric acid, malic acid, and N-(L-arginino) succinate, 1-pyrroline-4-hydroxy-2-carboxylate and 1-methylhistamine in the rats with IS. Additionally, AGNH obviously reduced Tyrobp, Syk, Tlr2, Myd88 and Ccl2 at both the mRNA and protein levels, decreased IL-1β, KC-GRO, IL-13, TNF-α, cleaved caspase 3 and p65 nucleus translocation, but increased IκBα expression. Network pharmacology analysis showed that quercetin, beta-sitosterol, baicalein, naringenin, acacetin, berberine and palmatine may play an important role in protecting against IS. Taken together, this study reveals that AGNH reduced neuroinflammation and protected against IS by inhibiting Tyrobp/Syk and Tlr2/Myd88, as well as NF-κB signalling pathway and regulating multiple metabolites.
The invention provides systems and methods for detecting and identifying cardiac pacing mapping sites and pacing maneuvers. Systems and methods for generating a pace mapping prediction model are disclosed. Techniques are provided for utilizing a training data set associated with cardiac biometrics of a patient, the training data set including electrophysiological data associated with cardiac arrhythmias, a pace-mapping data set, and correlation data that measures a degree of correlation between the pace-mapping data set and the electrophysiological data. Based on the training dataset, a pace mapping prediction model is trained to predict a degree of correlation between the electrophysiological data of the patient and the pace mapping dataset. Based on the predicted degree of correlation, a cardiac location in the patient's heart is predicted as a location for the next pace mapping. Other systems and methods for generating a pacing steering prediction model are disclosed. The pacing maneuver prediction model is trained to predict interval measurements based on pacing maneuvers obtained during cardiac pacing mapping.
This arm is optional based on Cohort 5. All participants in Cohort 6 will be receiving VIR-3434 monotherapy.
Participants, 190 healthy adults 18 to 64 years of age, will receive 1 intramuscular (IM) injection of Pfizer-BioNTech COVID-19 vaccine on Day 1, followed by a placebo dose on Days 21. Participants will receive a placebo dose on Day 28.
The global average life expectancy and the average age of the population are growing steadily along with the age-related diseases. The same trend is also observed in our country. Although, maximum life span in Russia decreases. E.g., the number of centenarians in Moscow decreased by 244 persons from 2013 to 2014. There were about 400 centenarians in Moscow in 2014. That is about 3.3 per 100 000 population. In the US, this figure is about 10-20, and there are 50 centenarians per 100 000 population in the Okinawa region, Japan. The rate of ageing varies substantially, a prime example of this is the centenarians population. These people break conventional stereotypes about aging. Chronic diseases in centenarians are postponed. They are more active, they work longer, they can better tolerate stressful situations. Scientists all over the world are trying to find the secret of their longevity. Studies on the medical and social aspects of centenarian longevity are actively carried out in the US, Europe, Japan, Australia. In Russia studies were carried out in St. Petersburg, Western and Eastern Siberia. According to the New England Centenarian Study, the supercentenarians (persons who have lived more than 110 years) life span is actually equal to the healthy span without serious illnesses. The aim of research is to study features of social status, lifestyle, habits, clinical status, blood chemistry, the amount of progerin, genome, composition of the gut microbiota in Moscow centenarians in order to create a model of healthy aging. In this study a comprehensive analysis of the longevity phenomenon of one hundred centenarians from Moscow and the Moscow region planning to be conducted. Analyzing of anamnesis vitae, medical, social, neuro-cognitive, and genetic features is planning. Each study participant will undergo a comprehensive geriatric assessment, including examination by the neurologist, an assessment of cognitive status,psychogeriatric consultation with the assessment of self-perceptions of aging and depression assessment by using the geriatric depression scale, neuropsychological testing using the Montreal Cognitive Assessment (MoCA), verbal recognition memory 12 word test, clock-drawing test.Telomere length and progerin level in buffy coat layer evaluation, 16sRNA metagenome sequencing, and nuclear magnetic resonance spectroscopy for qualitative and quantitative analysis of metabolites in blood serum, will be done in all participants. This study will take the science closer to the goal of identifying the patterns of "healthy" aging.
Participants in the Jamaica cohort are located at or near Spanish Town, Jamaica which is an urban area 25 km from the center of Kingston. The population of Spanish Town in 1991 was estimated at 92,000 people.
PURPOSE:To obtain xylofuranan sulfate having a high anticoagulant activity, by sulfating xylofuranan. CONSTITUTION:Xylofuranan sulfate of formula I (wherein n is 10-500 and R is H or SO3Na) is obtained by sulfating xylofuranan with a sulfating agent. When n in formula I is smaller than 10, the anticoagulant activity is decreased, while when it is larger than 500, the synthesis of this compound is difficult. Examples of the sulfating agents which can be used include sulfuric anhydride/ trimethylamine complex, chlorosulfonic acid and piperidine N-sulfate. Xylofuranan sulfate of formula I has an anticoagulant activity in the medical field and therefore a substance containing it as an effective component can be used as a medical polymeric material which must prevent coagulation of the blood, such as a material for artificial hearts and artificial blood vessels. Xylofuranan which is a starting material for xylofuranan sulfate can be obtained by, for example, a process shown in formula II (wherein Bn is CH2C6H5).
BACKGROUND: Elucidation of the interaction of biological and psychosocial/environmental factors on opioid dependence (OD) risk can inform our understanding of the etiology of OD. We examined the role of psychosocial/environmental factors in moderating polygenic risk for opioid use disorder (OUD).
METHODS: Data from 1958 European ancestry adults who participated in the Yale-Penn 3 study were analyzed. Polygenic risk scores (PRS) were based on a large-scale multi-trait analysis of genome-wide association studies (MTAG) of OUD.
RESULTS: A total of 420 (21.1%) individuals had a lifetime diagnosis of OD. OUD PRS were positively associated with OD (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.21-1.66). Household income and education were the strongest correlates of OD. Among individuals with higher OUD PRS, those with higher education level had lower odds of OD (OR 0.92, 95% CI 0.85-0.98); and those with posttraumatic stress disorder (PTSD) were more likely to have OD relative to those without PTSD (OR 1.56, 95% CI 1.04-2.35).
CONCLUSIONS: Results suggest an interplay between genetics and psychosocial environment in contributing to OD risk. While PRS alone do not yet have useful clinical predictive utility, psychosocial factors may help enhance prediction. These findings could inform more targeted clinical and policy interventions to help address this public health crisis.