anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Respiratory therapist determined extubation readiness based on: patent and protected airway; adequate secretion clearance; suction requirement ≤ every 2 hours; FiO2 \< 50% and PEEP = 5; and hemodynamic stability without circulatory support. The SBT included CPAP = 5 mmHg at FiO2 ≤ 0.4. Patients were assessed after 3-minutes for appropriateness to continue (SaO2 ≥ 92%; no arrhythmia; RSBI \< 105 breaths/min/L). Respiratory distress signs included RR \> 30 breaths/min, SaO2\< 90%, HR \> 140 beats/min, or a sustained change in HR of \>20%, systolic BP \>200 mmHg or \<80 mmHg, or agitation, anxiety, or diaphoresis without other cause. The SBT lasted 120 min in accordance with prior studies. Upon SBT completion, the RSBI was re-measured and an ABG was obtained.
During pulpotomy treatment, a blood sample was taken from the coronal pulp and stored. The remaining pulp tissue was covered with MTA, randomly selected from among four material groups. The teeth treated with MTA were monitored for 12 months. Subsequently, the levels of IL-6, IL-8, and Presepsin in the blood were measured using the ELISA method and noted in ng/ml. Thus, the effect of the material used on the success of the treatment was determined based on the level of pulpal inflammation before treatment.
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely surgery and oncology, and can be used for the prevention of postoperative pulmonary tromboembolism in the surgical treatment of patients with kidney cancer complicated by tumor thrombosis of the inferior vena cava (VCI). A median laparotomy is performed, the duodenum is mobilized by Kocher and displaced medially. The mobilization of the kidney with a tumor is performed. The renal artery is isolated and ligated. There are suprarenal, renal and infrarenal sections of the inferior vena cava, renal venous entries. During the revision, the height of the tip of the tumor thrombus is determined. Blood flow through the inferior vena cava is stopped. Unfractionated heparin is injected, 5000 units. After that, vascular clamps are applied above the level of the thrombus, to the contralateral renal vein and the infrarenal part of the inferior vena cava. Longitudinal venotomy of the inferior vena cava is performed in the suprarenal region. Thrombectomy of a tumor thrombus is performed. The kidney with a tumor thrombus and a renal vein is removed. Antegrade and retrograde blood flow is monitored. A venotonic incision is sutured with a 4/0 winding suture, the inferior vena cava is stitched 1 cm below the renal veins with transversely U-shaped sutures at a distance of 1 cm. Blood flow is restored, hemostasis is carried out. The wound is sutured tightly in layers.EFFECT: extension of the range of methods for prevention of postoperative pulmonary thromboembolism.1 cl, 2 dwg, 1 ex
Cohort C includes patients with non-small-cell lung cancer (NSCLC), bladder cancer; gastroesophageal (GE) cancer, any microsatellite unstable, or renal cell carcinoma (RCC) who are relapsed to prior PD-1/L1 therapy. Patients will receive a 14 day run-in of EDP1503 alone, following which they will be treated with a combination of EDP1503 and pembrolizumab.
PROBLEM TO BE SOLVED: To provide an adhesive bandage. SOLUTION: The adhesive bandage is provided with adhesive tapes (10 and 60) each having the outer surface part and the inner surface part. Each inner surface part has two adhesive end parts (13a) which are supported on the skin of users to be stuck onto the skins and an intermediate part (13b) for being supported on a skin area to be treated. The intermediate part (13b) carries a plurality of microcapsules (30) evenly distributed and the microcapsules (30) are so produced in the form of a material that contacts the skin area to be treated, hence being permissible as medicine. The microcapsules (30) break under an external pressure or being dissolved in a liquid exuding from the skin. Each of the microcapsules (30) houses at least one kind of active substance which provides at least one of narcotic, antiseptic, hemostatic, healing and antibiotic functions.
This study uses an experimental procedure called transcranial direct current stimulation (tDCS). Little is known about how tDCS affects the brain or why some people diagnosed with schizophrenia or schizoaffective disorder have trouble with certain kinds of hearing. This study is being done to see if an experimental computer training program, when combined with tDCS, can help people to hear better. In tDCS, a small amount of electricity is passed through electrodes placed on the head that is able to stimulate the brain. By stimulating the brain, the investigators believe that the functioning of the brain can be altered. This study will test whether such stimulation of the brain, when done with computer training, can improve hearing ability and if this improvement helps in other ways, like detecting changes in someone's tone of voice or understanding other people's emotions better. The data being collected aims to better understand how the brain processes sounds and how tDCS affects the brain.
Mesenchymal stem cells are pluripotent cells capable of differentiating into myocardial cells and vascular endothelial cells. It is intended to indicate that a mesenchymal stem cell sheet is likely usable as a remedy for highly damaged heart owing to the pluripotency and in situ autologous growth ability thereof. Mesenchymal stem cells originating in a fat tissue are cultured to prepare a mesenchymal stem cell sheet. Rats with cardiac infarction are constructed. After 4 weeks, the mesenchymal stem cell sheet is transplanted into the heart of the animals. Then, the mesenchymal stem cell sheet smoothly takes root in the scarred surface of the cardiac muscle and gradually grows in situ to form a thick layer (about 600 μm) within 4 weeks. The transplanted mesenchymal tissue thus growing contains newly formed blood vessels, myocardial cells and undifferentiated mesenchymal cells. The rooting mesenchymal stem cells prevent the myocardial wall in the scarred region from thinning and improve cardiac functions and survival rate in the rats with cardiac infarction. Namely, the transplantation of the mesenchymal stem cell sheet is usable as a novel therapy for myocardial tissue regeneration.
The FDA has the regulatory authority to reduce, but not eliminate, nicotine from cigarettes. The Tobacco Products Scientific Advisory Committee has noted, among other things, that removal of menthol cigarettes from the marketplace would benefit the public health. A parent study (NCT02048852) examines the potential impact of these two regulatory actions alone and in combination in female menthol smokers. This supplemental study will recruit an additional group of male menthol smokers, which will examine whether there are gender differences in manipulating flavors and nicotine concentrations in cigarettes on smoking behavior. The approach to add the opposite sex allows findings of sex/gender to be incorporated in the design and development of new technologies (i.e., modified cigarettes). Emerging research shows that women may be more responsive to the non-nicotine sensory aspects of smoking such as menthol flavor, whereas men may smoke primarily for nicotine intake. Consequently, this study expects to observe gender differences in response to manipulating flavors and nicotine content in cigarettes.
Participants received 45 mg upadacitinib once daily (QD) for 8 weeks. Participants who did not achieve clinical response per Adapted Mayo score at Week 8 received upadacitinib 45 mg once daily for 8 additional weeks in the open-label extension period.
Participants with advanced (Stage IV) or recurrent non-squamous NSCLC will be administered placebo corresponding to 340 mg pictilisib plus carboplatin (C) plus paclitaxel (P). Participants with investigator assessed radiographic progression of NSCLC per RECIST 1.1 will be allowed to cross over to Arm C during the first 4 cycles with carboplatin + paclitaxel + bevacizumab or after chemotherapy has been completed (Cycle \>/= 5).
PURPOSE: Stroke-associated pneumonia (SAP) usually complicates stroke and is linked to adverse prognoses. Triglycerides, total cholesterol, and body weight index (TCBI) is a new and simple calculated nutrition index. This study seeks to investigate the association between TCBI and SAP incidence, along with its predictive value.
PATIENTS AND METHODS: Nine hundred and sixty-two patients with acute ischemic stroke were divided into SAP group and Non-SAP group. The TCBI was divided into three layers: T1, TCBI < 948.33; T2, TCBI 948.33-1647.15; T3, TCBI > 1647.15. Binary Logistic regression analysis was used to determine the relationship between TCBI levels and the incidence of SAP. Furthermore, restricted cubic splines (RCS) analysis was utilized to evaluate the influence of TCBI on the risk of SAP.
RESULTS: TCBI in the SAP group was markedly lower compared to that in the Non-SAP group (P < 0.001). The Logistic regression model revealed that, using T3 layer as the reference, T1 layer had the highest risk for SAP prevalence (OR = 2.962, 95% CI: 1.600-5.485, P = 0.001), with confounding factors being controlled. The RCS model found that TCBI had a linear relationship with SAP (P for nonlinear = 0.490, P for overall = 0.004). Moreover, incorporating TCBI into the A2DS2 (Age, atrial fibrillation, dysphagia, sex, and severity) model substantially enhanced the initial model's predictive accuracy.
CONCLUSION: Low TCBI was associated with a higher risk of SAP. In clinical practice, TCBI has shown predictive value for SAP, contributing to early intervention and treatment of SAP.
Intervention participants were provided with a cognitive-behavioral 12-week program consisting of varenicline (1mg bid, with initial titration up over week 1) and smoking cessation counseling targeted to the issues of thoracic cancer patients. We offered 7 counseling sessions but were flexible in offering additional counseling when needed. Counseling was delivered by a certified Tobacco Treatment Counselor using Motivational Interviewing (MI) techniques.
Corticosteroid use may be associated with severe psychiatric adverse reactions. Euphoria, mania, psychosis with hallucinations and delirium or depression have been seen in patients at replacement doses of hydrocortisone [see Adverse Reactions ( 6)] . Symptoms typically emerge within a few days or weeks of starting the treatment. Risks may be higher with high doses, although dose levels do not allow prediction of the onset, type, severity or duration of reactions. Most reactions resolve after either dose reduction or withdrawal, although specific treatment may be necessary. Monitor patients for behavioral and mood disturbances during treatment with ALKINDI SPRINKLE. Instruct caregivers and/or patients to seek medical advice if psychiatric symptoms develop.
TAVI is performed according to current guidelines and the choice of transcatheter heart valve is at the operators' discretion. PCI is performed in any suitable lesion with diameter stenosis \> 90% or FFR ≤ 0.80 in vessels ≥ 2.5 mm in diameter .
The current study will be randomized control trial and data will be collected from (PSRD) pakistan society rehablitation of the disabled. The study will include 44 patients equally divided into two groups and randomly allocated. Inclusion criteria for the study will be a parent-confirmed ASD diagnosis from a psychiatrist or licensed psychologist, both male and female children, age between 4 to 14 years. Children with a history of lower limb surgery, a recent (\<1 year) ankle sprain and severe behavioral disturbances will be excluded from the study. Experimental group will have ankle weighted cuffs while performing routine physical therapy exercises. Control group will perform routine physical therapy exercises. Outcomes will be analyzed by Limb Position Sense Test and 50 ft walk test. Data collection will be done before and after the intervention. Data will be analyzed through SPSS version 25.00.
PURPOSE:To provide an adhesive compsn. for biotic materials which is excellent in adhesion to dentin, living bones, etc., mainly composed of calcium phosphate and particularly exhibits a stable long-term adhesion under such wet conditions as lining organisms, by using a specific fluorinated acrylic ester as the main constituent. CONSTITUTION:An adhesive compsn. for biotic materials is made up of a compd. of formula I (wherein A is H, F or CH3; and B is 1-20C fluoroalkyl), or contains as the main constituents the above-mentioned compd. and other compd. copolymerizable therewith. The compd. of formula I, or the above-mentioned compd. and other compd. copolymerizable therewith may be used in the form of a monomer(s) and/or a polymer thereof. Examples of the above-mentioned other copolymerizable compd. include acrylic acid, methacrylic acid, and esters thereof.
A smart health management system applicable to the health management of a user includes a cloud database and a mobile device. The mobile device is coupled to the cloud database and includes a memory, a communication unit, a display, and a processor. This memory is used to store a smart health management application. The processor is electrically connected to the memory, the communication unit, and the display, and is configured to execute the smart health management application. The process is as follows: obtain an electronic medical record associated with the user; retrieve at least one medical record keyword in the electronic medical record; through the communication unit, query the cloud database with the retrieved medical record keyword; and display the query result on the display. The present invention can also promptly remind the user to take medicine and record time by visual and/or voice, so that the user can actively change the lifestyle and improve health condition.
Obesity can predispose people to develop high pressures inside their lung blood vessels, a condition called pulmonary hypertension, Pulmonary hypertension in turn, can lead to shortness of breath and other health complications such as heart failure. In this study, we seek to identify individuals at risk for the development of high pressures inside lung vessels based on BMI and dyspnea grade 1.

Participants will be screened by echocardiography to estimate pulmonary pressures. Potential participants will undergo invasive cardiopulmonary exercise testing with hemodynamic monitoring, in order to identify individuals with abnormal pulmonary vascular function either at rest or during exercise. Patients who have undergone clinically-indicated cardiopulmonary exercise testing and meet inclusion/exclusion criteria will also be recruited. Those with abnormal pulmonary vascular function will be randomized to receive Metformin or placebo for a total of 3 months under an IND exemption. The primary outcomes include the effect on pulmonary vascular function at rest and during exercise. Secondary outcomes include change in pulmonary artery endothelial cell phenotypes.
Subjects will receive rituximab intravenously at a dose level of 375 mg/m² on day 1 of each cycle followed by inotuzumab ozogamicin administered intravenously at a dose level of 1.8 mg/m2 on day 2. The sequence will be repeated every 28 days.
The present invention relates to series medicated meat stewed products which are manufactured with the natural plant of roots of Szechwan-Yunnan sanicle as main supplementary material and with meat as main material. The stewed products are mainly formed by stewing the roots of Szechwan-Yunnan sanicle and the meat, and other supplementary material can also be added. The proportion of the roots of Szechwan-Yunnan sanicle to the meat to water is 10 to 50 grams: 1000 to 2000 grams: 2500 to 4000 grams. The other supplementary material comprises one or some of notoginseng, codonopsis pilosula, dried orange peel, Chinese wolfberry, tsaoko, longan, Chinese dates, amomun fruit, Chinese angelica and salt. The meat is mainly one or some of chicken, mutton, beef, pork, dog meat, fish and duck meat. The medicated meat stewed products have the advantages of unique fragrance, fresh fragrance, palatability, appetite stimulation, spleen strengthening, kidney tonifying, long shelf life, rich nutrients and the capacity of being eaten in four seasons. As the roots of Szechwan-Yunnan sanicle are added, the stewed products can be put for two to three days at room temperature without deterioration.
Phase I dose level 2 participants received nivolumab 1 mg/kg and ipilimumab 3 mg/kg intravenously (IV) on day 1 of each 21-day cycle and troriluzole 140 mg twice per day orally. Participants were treated until disease progression or unacceptable toxicity.
PURPOSE: To obtain a new compound having platelet aggregation-suppressing action, bronchodilatation or vasodepressor activity and useful as an antiplatelet agent, a bronchodilator or an antihypertensive agent. CONSTITUTION: This compound is expressed by formula I (A is a lower alkylene; R is a lower alkoxycarbonylamino, an alkanoylamino, etc.,; Y is H, nitro, etc., with the proviso that when R is acetylamino and Y is H, A is not ethylene and R is methoxycarbonyl and when Y is H, A is not methylene) or its salt, e.g. methyl 1-hydroxyindole-3-propionate. The compound is obtained by oxidizing 2,3-dihydroindole compound of formula II with an oxidizing agent (preferably combination, etc., of sodium tungstate and hydrogen peroxide). Furthermore, the compound of formula II is obtained by treating, e.g. an indole compound of formula III with sodium cyanoborohydride in acetic acid.
Participants will be asked to maintain their normal physical activity and dietary habits during the 12-week intervention. Physical activity, diet, urine and blood samples will be collected every 4 weeks. Each participant will consume 3 HMB+VitD capsules, twice a day with a meal or snack for a total of 6 capsules per day. Each capsule contains 500 mg calcium HMB and 333.33 IU Vitamin D for a total of 3.0 g HMB and 2000 IU Vitamin D per day.
A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both  Haemophilus influenzae  and  Moraxella catarrhalis . Such composition comprises at least four antigens comprising at least one antigen from  Haemophilus influenzae , and at least one antigen from  Moraxella catarrhalis . Three of the antigens are adhesins. High molecular weight (HMW) proteins and  Haemophilus influenzae  adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of  Moraxella catarrhalis  comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.
Chemokines are important immune system proteins, many of which mediate inflammation due to their function to activate and cause chemotaxis of leukocytes. An important anti-inflammatory strategy is therefore to bind and inhibit chemokines, which leads to the need for biophysical studies of chemokines as they bind various possible partners. Because a successful anti-chemokine drug should bind at low concentrations, techniques such as fluorescence anisotropy that can provide nanomolar signal detection are required. To allow fluorescence experiments to be carried out on chemokines, a method is described for the production of fluorescently labeled chemokines. First, a fusion-tagged chemokine is produced in Escherichia coli, then efficient cleavage of the N-terminal fusion partner is carried out with lab-produced enterokinase, followed by covalent modification with a fluorophore, mediated by the lab-produced sortase enzyme. This overall process reduces the need for expensive commercial enzymatic reagents. Finally, we utilize the product, vMIP-fluor, in binding studies with the chemokine binding protein vCCI, which has great potential as an anti-inflammatory therapeutic, showing a binding constant for vCCI:vMIP-fluor of 0.37 ± 0.006 nM. We also show how a single modified chemokine homolog (vMIP-fluor) can be used in competition assays with other chemokines and we report a Kd for vCCI:CCL17 of 14 μM. This work demonstrates an efficient method of production and fluorescent labeling of chemokines for study across a broad range of concentrations.
PURPOSE:To prepare the titled proliferation inhibiting agent having little side effect, by culturing malignant tumor cells of an animal, removing the cultured cells from the medium, subjecting the medium to the ultrafiltration with an ultrafiltration membrane having a specific critical molecular weight, and collecting the fraction having a molecular weight higher than a specific level. CONSTITUTION:Malignant tumor cells of an animal (including human) are cultured, and the proliferated cells are removed from the medium. The obtained medium is subjected to the ultrafiltration with an ultrafiltration membrane having a critical molecular weight of 500 (e.g. VM05 produced by Amicon Ltd.), and the fraction having a molecular weight of >=500 is collected to obtain the objective agent to inhibit the proliferation of the malignant tumor cells of an animal. The fraction having a molecular weight of >=500 and obtained by the above process is found to have remarkably high effect to inhibit the proliferation of the cells compared with the fraction having a molecular weight of <500. It exhibits high proliferation-inhibiting effect even under diluted state, and the preparation obtained by the above process is almost free of side effects in contrast with conventional antitumor agents.
Participants will receive single oral dose of midazolam 6 milligram (mg) on Day 1 and 17. Participants will self-administer esketamine intranasally thrice per day on morning of Day 2, 5, 9, 12 and 16 (84 mg).
Music is well-known to elicit ergogenic effects on exercise performance; however, the moderating role of application timing remains unclear. This study examined the effects of the timing of music on fatigue perception and performance during isometric strength exercises. Using a within-subject, randomised crossover design, twelve recreationally active young adults performed two isometric strength tasks (plank-hold and wall-sit) in three separate conditions (MEE: music played during the entire exercise task; MDF: music played during fatigue alone; CON: no music). The total time to volitional exhaustion (TTE), time to the onset of fatigue perception (TFP), heart rate, and blood lactate responses were assessed during each trial. MEE resulted in a significantly longer TTE than CON in both the plank-hold (p < 0.05, d = 0.76) and wall-sit exercises (p < 0.05, d = 0.72), whereas MDF led to a significantly longer TTE than CON in wall-sit exercises alone (p < 0.05, d = 0.60). TFP was significantly longer in MEE than in CON in both the plank-hold (p < 0.05, d = 0.54) and wall-sit exercises (p < 0.05, d = 0.64). The music condition did not influence the heart rate or blood lactate changes in any of the trials. Our results suggest that listening to music during the entire exercise can delay the onset of fatigue perception in isometric strength tasks, whereas listening to music during fatigue has only a modest effect. Athletes and exercisers should consider extending music exposure throughout the entire exercise task to maximise performance benefits.