anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine, virology. SUBSTANCE: invention provides vaccine compositions of attenuated respiratory-syncytial virus (RSV). Moreover, attenuated virus can be derivative of RSV which was partially attenuated by passage in the cold or by mutations insertion that make virus showing phenotype sensitive to temperature (ts) or adapted to cold (ca). Invention provides methods of individual immune system stimulation for inducing protection against respiratory-syncytial virus by administration of attenuated RSV. Invention provides also pure cultures of attenuated RS virus in which this virus is attenuated more completely by the further derivatization (derivatives preparing) early identified as noncomplete attenuated mutants ts and cp. EFFECT: improved method of stimulation.
The invention relates to a anthocyanin steady-state complex and a preparation method and application thereof. The preparation method comprises the following steps: mixing the anthocyanin chitosan embedding body and the liposome material in a dispersion medium; the anthocyanin chitosan embedding body is embedded with at least two kinds of anthocyanins. The invention is based on a chitosan embedding body embedded with at least two kinds of anthocyanin, the chitosan embedding body is further mixed with liposome materials, and a layer of liposome is embedded outside the chitosan to form a complex with closed vesicles with a bilayer structure. The composite can effectively take stability of different kinds of anthocyanin into consideration, and avoid the phenomenon of color change caused by breaking composite color balance. Furthermore, the inventors have found that the complex is more soluble in the oil phase, and that the cosmetic prepared therefrom is advantageous for the absorption of functional ingredients into the skin. Meanwhile, the complex is used as pigment to prepare cosmetics, is green, natural and free of additives, resists oxidation, moistens and prevents chapping, repairs lines and improves skin color.
The invention relates to a heat clearing and detoxifying traditional Chinese medicine oral liquid. The oral liquid is prepared from following raw materials: 9 g of mulberry leaf, 9 g of chrysanthemum flower, 12 g of dyers woad leaf, 12 g of weeping forsythia capsule, 6 g of mint, 20 g of gypsum, 15 g of common anemarrhena rhizome, 15 g of reed rhizome, 12 g of snakegourd fruit, 9 g of bamboo shavings, 12 g of platycodon root, 9 g of tendrilleaf fritillary bulb, 10 g of cassia twig, 9 g of ephedra, 9 g of fineleaf schizonepeta herb, 6 g of stir-fried bitter apricot seed and 12 g of liquorice root. A preparing method includes weighing the abovementioned traditional Chinese medicines, adding 1500 mL of water, decocting with soft fire for 45 min, filtering to obtain a medicine liquid, cooling, adding 30 mL of honey, and fully stirring. The oral liquid is divided into two parts with one part being taken in the morning and the other part being taken at night. A course of treatment comprises three days. The oral liquid is rich in medicine sources, low in cost, convenient to use and obvious in effects.
PURPOSE: In Ireland, over 3000 patients are diagnosed with breast cancer annually, and 1 in 9 Irish women will be diagnosed with breast cancer in their lifetime. There is evidence that female breast cancer survivors are more likely to die of cardiovascular disease than their age-matched counterparts. Specific services for cancer patients suffering from cancer therapy related cardiovascular toxicity have led to a higher incidence of safe anti-cancer treatment completion. Such services are not widely available in our jurisdiction, and the purpose of this trial is to remedy this situation.
METHODS: This protocol describes a prospective, single arm, pilot feasibility study implementing a dedicated Cardio-Oncology assessment and surveillance pathway for patients receiving multimodal breast cancer treatment. It incorporates novel biomarker and radiomic surveillance and monitoring approaches for cancer-therapy related cardiac dysfunction into routine care for breast cancer patients undergoing adjuvant systemic chemotherapy.
RESULTS: Declaration of results will via peer reviewed academic journals, and communicated directly to key knowledge users both nationally and internationally. This engagement will be critical to enable to healthcare services and policy sector make informed decisions or valuable changes to clinical practice, expenditure and/or systems development to support specialized Cardio-Oncology clinical pathways. All data is to be made available upon request.
CONCLUSION: Dedicated cardio-oncology services have been recommended in recent literature to improve patient outcomes. Our protocol describes a feasibility study into the provision of such services for breast cancer.
BACKGROUND: IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, which is a significant cause of renal failure. At present, the classification of IgAN is often limited to pathology, and its molecular mechanism has not been established. Therefore we aim to identify subtypes of IgAN at the molecular level and explore the heterogeneity of subtypes in terms of immune cell infiltration, functional level.
METHODS: Two microarray datasets (GSE116626 and GSE115857) were downloaded from GEO. Differential expression genes (DEGs) for IgAN were screened with limma. Three unsupervised clustering algorithms (hclust, PAM, and ConsensusClusterPlus) were combined to develop a single-sample subtype random forest classifier (SSRC). Functional subtypes of IgAN were defined based on functional analysis and current IgAN findings. Then the correlation between IgAN subtypes and clinical features such as eGFR and proteinuria was evaluated by using Pearson method. Subsequently, subtype heterogeneity was verified by subtype-specific modules identification based on weighted gene co-expression network analysis(WGCNA) and immune cell infiltration analysis based on CIBERSORT algorithm.
RESULTS: We identified 102 DEGs as marker genes for IgAN and three functional subtypes namely: viral-hormonal, bacterial-immune and mixed type. We screened seventeen genes specific to viral hormonal type (ATF3, JUN and FOS etc.), and seven genes specific to bacterial immune type (LIF, C19orf51 and SLPI etc.). The subtype-specific genes showed significantly high correlation with proteinuria and eGFR. The WGCNA modules were in keeping with functions of the IgAN subtypes where the MEcyan module was specific to the viral-hormonal type and the MElightgreen module was specific to the bacterial-immune type. The results of immune cell infiltration revealed subtype-specific cell heterogeneity which included significant differences in T follicular helper cells, resting NK cells between viral-hormone type and control group; significant differences in eosinophils, monocytes, macrophages, mast cells and other cells between bacterial-immune type and control.
CONCLUSION: In this study, we identified three functional subtypes of IgAN for the first time and specific expressed genes for each subtype. Then we constructed a subtype classifier and classify IgAN patients into specific subtypes, which may be benefit for the precise treatment of IgAN patients in future.
INTRODUCTION: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are emerging areas of interest.
AREAS COVERED: In this review, we provide an overview of development of the microbiome during childhood. We highlight available data suggesting that the microbiome is critical to maturation of the immune system and modifies susceptibility to a variety of infections during childhood and adolescence, including respiratory tract infections, Clostridioides difficile infection, and sexually transmitted infections. We discuss currently available and investigational therapeutics that have the potential to modify the microbiome to prevent or treat infections among children. Finally, we review the accumulating evidence that the gut microbiome influences vaccine-elicited immune responses among children.
EXPERT OPINION: Recent advances in sequencing technologies have led to an explosion of studies associating the human microbiome with the risk and severity of infectious diseases. As our knowledge of the extent to which the microbiome influences childhood infections continues to grow, microbiome-based diagnostics and therapeutics will increasingly be incorporated into clinical practice to improve the prevention, diagnosis, and treatment of infectious diseases among children.
Subjects with maculoschisis may be offered topical treatment with CAIs. These subjects will be asked to visit the study site at 1 month and 3 months after starting topical treatment. During these additional visits, subjects will undergo a dilated eye exam, BCVA, and SD-OCT imaging to assess efficacy of treatment (i.e. reduction of maculoschisis).
The invention relates to a composition comprising palythine, or salts thereof, in an amount of 0.3% to 25% by weight, wherein palythine, or salts thereof, is the sole active ingredient. The invention also relates to said composition formulated for application to skin. The invention also relates to said composition formulated as a moisturiser. The invention also relates to a method of protecting a subject against skin damage, and/or against UVA damage, and/or against skin aging, and/or against UVB damage, and/or against reactive oxygen species generated by UVR, said method comprising applying said composition to the skin of said subject. The invention also relates to a cosmetic method of maintaining skin appearance of a subject, said method comprising applying said composition to the skin of said subject. The invention also relates to use of palythine, or salts thereof, as a sun filter.
The whole eligible population of Swedish climbers on elite- or sub-elite levels of competition will be invited to participate in the study. Participants will be both male and female, 13 years and older. There are approximately 40 climbers eligible at elite level and a minimum of 80 climbers at sub-elite level of competition.
Patients with ACS who underwent coronary angiography within 72 hours from the onset of disease. In identifying nonobstructive coronary atherosclerosis , patients underwent cardiac contrast MRI.
The prospective registry shall provide new insights into the multiple associations, and respective therapeutic implications of cardio-vascular risk factors and stroke. For that reason consecutive patients with ischemic stroke/transient ischemic attack (brain, spinal cord, or retinal) and structural (e.g. patent foramen ovale), septic or aseptic endocarditis or myocarditis, or supra-ventricular or ventricular arrhythmia, who are admitted to our University Hospital, are enrolled. Multifactorial assessment of risk factors is based on medical history, laboratory biomarkers, electrocardiogram incl. cardiac autonomic function analysis, and (long-term) cardiac rhythm monitoring, as well as transthoracic and transesophageal echocardiography. Inclusion of follow-up visits permit longitudinal and prognostic evaluation of routine diagnostic and therapeutic interventions for secondary stroke prevention (e.g. implantable loop recorders or interventional closure of patent foramen ovale).
The investigators used percutaneously US-guided laser ablation for patients with small hepatocellular carcinoma (single or multiple nodules of less than 3 cm in diameter), Child-Pugh A/B, PLT ≥ 50\*10E9/L and PT ≤ 20s. Then the investigators estimated the safety and efficacy of this treatment through follow-up of US/CEUS/CT/MRI and the tumor markers every three months.
Polycystic ovary syndrome (PCOS) is an increasingly recognized endocrine disorder. The pathogenesis is not fully known. Polycystic ovary syndrome is still difficult to diagnose correctly, despite simple diagnostic criteria. The aim of the study is to review the current knowledge about PCOS and treatment options for patients with the disease. To explore this topic, publications were reviewed and conclusions drawn from them. The incidence of hyperandrogenism in a patient with PCOS may be as high as 60-80%. Increased androgen levels affect ovulation and menstruation, and also result in hirsutism and acne. Additionally, patients have problems with proper glucose tolerance (insulin resistance), type 2 diabetes, hypertension, cardiovascular diseases and metabolic syndrome. PCOS results in various symptoms in patients. The latest treatment methods were analysed. A standard review of publications in the field of diagnosis and treatment of PCOS, IR and hyperandrogenism was used. Lifestyle, especially diet, deserves special attention due to its ease of use. Sleep quality, physical activity and stress reduction are also important. Diet should be the treatment of first choice. Only if dietary intervention does not bring results, the doctor considers pharmacotherapy. Recently, acupuncture and herbal medicine, vagus nerve stimulation have been used in the treatment of PCOS and regulation of hormone levels. Patients are given supplementation to improve the quality of functioning, but it must be remembered that inappropriate doses or too long use may result in a toxic effect opposite to the therapeutic one. Appropriate diet, physical activity - lifestyle changes are crucial in the treatment of PCOS. Supplementation and pharmaceuticals support treatment. It is mandatory to examine these environmental and lifestyle factors as they not only contribute to the occurrence of the disease but also influence its progression.
The invention discloses an application of a urea transporter (UT) inhibitor Youti, of which the structural formula is represented as the formula I. In the invention, by means of erythrocyte model screening, the compound inhibiting the UT is obtained. An experimental result proves that the compounds, such as the Youti, can inhibit the permeability, induced by the UT-B, of urea through erythrocytes membrane, wherein the effect of the Youti has a dosage dependent relationship. In an effective dosage range, the Youti is free of cyto-toxicity on MDCK cells, which proves that the effect of inhibition the permeability of the urea through cells by the Youti is independent of the cyto-toxicity. The Youti is gradually enhanced in the inhibition effect on the UT-B and the inhibition effect of the Youti on the UT-B is reversible. An in-vivo test result proves that the Youti can significantly increase the urine output of mice, can reduce the concentration of urea in the urine of mice and can reduce the osmotic pressure, so that it is proves that the Youti has a urea-selective diuretic effect in-vivo.
Systems and methods are described that facilitate generating and storing a concentrated copper and silver ion solution for treating a remote water volume (e.g., a pool, fountain, hot tub, cooling tower, etc.), in accordance with various features described herein. Citric acid and a water-soluble binding polymer are added to a volume of water. The intermediate solution is circulated past an ion generator for a predetermined time period, and copper ions generated thereby are bound by the binding polymer and/or chelated by the citric acid. Once a desired concentration of copper ions has been achieved, the concentrated solution is stored in portable vessels for transport to the remote water volume. Concentrated solution is added to the remote water volume to achieve a concentration therein of approximately 0.2-0.3 ppm.
OBJECTIVE: The search for other indicators to assess the weight and nutritional status of individuals is important as it may provide more accurate information and assist in personalized medicine. This work is aimed to develop a machine learning predictions of weigh status derived from bioimpedance measurements and other physical parameters of healthy younger volunteers from Southern Cuba Region.
METHODS: A pilot random study at the Pediatrics Hospital was conducted. The volunteers were selected between 2002 and 2008, ranging in age between 2 and 18 years old. In total, 776 female and male volunteers are studied. Along the age and sex in the cohort, volunteers with class I obesity, overweight, underweight and with normal weight are considered. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. The bioimpedance analyser is used, collecting fundamental bioelectrical and other parameters of interest. A classification model are performed, followed by a prediction of the body mass index.
RESULTS: The results derived from the classification leaner reveal that the size, body density, phase angle, body mass index, fat-free mass, total body water volume according to Kotler, body surface area, extracellular water according to Kotler and sex largely govern the weight status of this population. In particular, the regression model shows that other bioparameters derived from impedance measurements can be associated with weight status estimation with high accuracy.
CONCLUSION: The classification and regression predictive models developed in this work are of the great importance to assist the diagnosis of weigh status with high accuracy. These models can be used for prompt weight status evaluation of younger individuals at the Pediatrics Hospital in Santiago de Cuba, Cuba.
FIELD: medicine. SUBSTANCE: invention proposes biologically active substance containing vegetable raw and reduced iron, precipitate sulfur and a filling agent. Biologically active substance shows effect on human body in liver, lung and digestive tract diseases and provides the expressed enhancement of regeneration of damaged tissues. Invention can be used as biologically active substance with broad spectrum of pharmacological effect. EFFECT: valuable medicinal properties of substance. 2 tbl, 3 ex
FIELD: medicine. ^ SUBSTANCE: invention concerns a freshening composition. A freshening chewing product containing a base and at least one coating layer applied which contains a fast-release antimicrobial agent representing the synergistic relation of magnolia bark extract and a surface-active substance. A freshening chewing product containing a base including a water-insoluble part and a water-soluble part; and a glase coat on said basis containing an effective amount of an antimicrobial agent containing the synergistic relation of magnolia bark extract and a surface-active substance. A method for making a freshening chewing product involving preparation of the base and glase coating with a homogeneous mixture containing the synergistic relation of magnolia bark extract and a surface-active substance. ^ EFFECT: higher ability to inhibit the oral formation of a biological film due to the synergistic combinations of the components. ^ 21 cl, 11 tbl
PURPOSE: To prepare a pharmaceutical composition for a rectal or a vaginal agent, comprising an effective substance, a carrier substance and a hydrocolloid and capable of carrying out the release control of the effective substance by interactions with a local body fluid. CONSTITUTION: This pharmaceutical composition comprises an effective substance such as a low- to a medium-molecular weight polypeptide (e.g. insulin) or an analgesic agent (e.g. morphine) suitable for the systemic therapy or an antifungal agent (e.g. clotrimazole) or a hormone (e.g. estradiol) suitable for the local rectal and vaginal therapies and further a hydrocolloid in an amount of 5-99.9wt.%, especially 40-90wt.% based on the total weight of the composition, if possible, together with a carrier substance without substantially containing fats. Starch, swellable polysaccharides, a cellulosic derivative, a salt of polyacrylic acid, etc., are used as the hydrocolloid. The composition is sealed in a capsule having a hard easing, especially the one made of gelatin or starch and administered.
Cancer is the second leading cause of death worldwide. >90 % of cancer-related deaths are due to metastasis, a process that depends on the ability of cancer cells to leave the primary tumor, migrate, and colonize different tissues. Inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca2+ signaling plays an essential role in maintaining the homeostasis of cancer cells and the sustained proliferation. Desmethylxestospongin B (dmXeB) is a specific inhibitor of the IP3R that selectively arrests cell proliferation and promotes cancer cell death at high concentrations. However, whether migration, invasion and metastasis can be affected by this drug is unknown. Here, by using the highly metastatic triple negative breast cancer (TNBC) cell line MDA-MB-231, we demonstrate that a prolonged inhibition of IP3R-mediated Ca2+ signals with dmXeB significantly reduces cell migration and invasion in vitro and metastasis in vivo. We found that this phenomenon was independent of the bioenergetic control of IP3R over the mitochondria and AMPK activation. Furthermore, employing a tandem LC3-GFP-mcherry assay, we found that prolonged inhibition of IP3R with dmXeB leads to diminished autophagic flux. This reduction can be attributed to impaired lysosomal acidification, as evidenced by assessments using DQ-BSA and pHrodo. Since cell migration requires appropriate assembly and disassembly of focal adhesions, along with the internalization and recycling of integrins via autophagy, we explored the dependency of integrin recycling from autophagosomes, finding that IP3R inhibition with dmXeB impaired the recycling of β1-integrins, which accumulated within autophagosomes. Our findings reveal an unexpected effect of IP3R inhibition with dmXeB in cancer cells that could represent a novel therapeutic strategy for the treatment of cancer metastasis.
Tinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus. It is a frequent problem which can interfere significantly with the ability to lead a normal life. Treatment is difficult. Most available therapies focus on habituation rather than treating the cause. Tinnitus is thought to be generated in the brain, as a result of functional reorganization of auditory neural pathways and tonotopic maps in the central auditory system, following damage to the peripheral auditory system. Low-frequency rTMS has been investigated for the treatment of hyperexcitability disorders such as auditory hallucinations and tinnitus. Pilot data indicate that the beneficial effect of low-frequency rTMS can be enhanced by high frequency rTMS of the left dorsolateral prefrontal cortex (DLPFC). In the proposed study we investigate whether high frequency rTMS of the DLPFC improves therapeutic efficacy of low-frequency rTMS on tinnitus in a controlled trial.
Leucine enriched essential amino acids (4g total, of which 1.6g are leucine). 20g carbohydrate, 2g of protein free drink powder, and 5g of Splenda to mask taste.
Healthy volunteers who are cognitively normal will have one PET scan with 11C-ER176, with arterial sampling. If the subject lacks known AD-biomarkers, they may undergo an 18F-florbetaben PET scan prior to the 11C-ER176 PET scan. Genome-wide genetic analysis will be performed. Participants will undergo an annual clinical evaluation and blood sample collection for 5 years to establish the trajectory of AD-related serum biomarkers and syndromic diagnoses.