anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a Qile traditional Chinese medicine health liquor made from a health traditional Chinese medicine composition and baijiu. The health traditional Chinese medicine comprises in parts by weight: Semen Sesami Nigri, Flos Dolichoris Lablab, Herba Epimedii, Rhizoma Dioscoreae, Arillus Longan, Fructus Jujubae 70-150 parts, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Semen Juglands, Bulbus Lilii and the like. In the preparation method of the medicinal liquor, various traditional Chinese medicinal materials are sewn to a medicine bag. In the soaking process, the medicine bag is suspended in soaking baijiu so that the components in the medicine bag can be released more easily. In addition, the Qile traditional Chinese medicine health liquor has good functions of resisting fatigue, enhancing immunity and building body, the basic reason is that the traditional Chinese medicinal materials can supplement one another, and thus a good health function is achieved. Compared with the prior art, the Qile traditional Chinese medicine health liquor has simple materials and is handy and easy to formulate.
<P>PROBLEM TO BE SOLVED: To provide injectable polysaccharide-cell compositions.  <P>SOLUTION: Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering a large number of isolated cells via injection. The gels promote engraftment and provide three-dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occurring tissue. This method can be used for a variety of reconstructive procedures, including custom molding of cell implants to reconstruct three-dimensional tissue defects as well as general implantation of tissues. Examples demonstrates the construction of muscles and cartilage tissues which are useful to repair defects such as reflux and incontinence.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Disclosed is a diagnostic method for determining the presence or absence of airborne contaminants. This involves applying a nasal topical application product for restricting the flow of airborne contaminants near human nasal passages to create a proximate and enhanced electrostatic field. This attracts and holds the airborne contaminant for subsequent presentation to known diagnostics testing. The nasal application product includes: (a) a plurality of masses of one or more electrostatic polymers; (b) a topical carrier having the plurality of masses dispersed through a portion thereof. The nasal application product may be topical solutions, semisolids, spray solutions and vaporizable solutions. Topical applications may be in the form of ointments, pastes, creams and gels. The carrier of the nasal application product of the present invention may be selected from the group consisting of diluents, volatile spray carriers, lotions, solvents, gels and hydro-gels. In some embodiments, substrates, e.g., bandage type substrates, with adhesive on one side and the product polymer(s) and carrier on the opposite side, may be employed. In other embodiments a fluid, which when dried to film is removable by peeling for testing, may by utilized.
<b>Introduction:</b> Chronic rhinosinusitis (CRS) is a long-lasting inflammatory condition affecting the sinonasal mucosa, which is likely triggered by a dysfunctional immune response. Vitamin D is recognized as an immunomodulator influencing both innate and adaptive immunity. Recently, this mechanism of action has sparked interest regarding the possible role of vitamin D in CRS pathogenesis and/or course of the disease.<b>Aim:</b> The aim of this study was to investigate the association between preoperative serum vitamin D levels and an early outcome of endoscopic sinus surgery (ESS) as well as its influence on the severity of CRS.<b>Materials and methods:</b> This prospective observational study included 25 patients with CRS with nasal polyps undergoing ESS and 18 healthy controls. The disease was confirmed clinically and radiologically. Demographic and clinical data for each subject were collected. Preoperatively, disease severity was evaluated by the patient using the Visual Analog Scale (VAS) and 22-item Sino-Nasal Outcome Test (SNOT-22), and by a researcher using the Lund-MacKay (LMS) and Lund-Kennedy (LKS) scoring systems. On the day of surgery, serum 25-hydroxyvitamin D was measured with the use of electrochemiluminescence binding assay. Six weeks postoperatively, reassessment was performed, including the VAS, SNOT-22, and LKS.<b>Results:</b> Serum 25-hydroxyvitamin D level was not significantly lower in CRS patients compared to healthy controls. Subjective and objective measures of CRS severity showed no correlation with vitamin D status. However, participants with higher vitamin D levels presented better outcomes 6 weeks postoperatively.<b>Conclusions:</b> Contradicting numerous previous studies, these findings failed to confirm the correlation between the occurrence or severity of CRS and vitamin D status. Nevertheless, vitamin D status seems to affect ESS early outcomes.
The embodiment of the invention provides a medical insurance fraud identification method, device, equipment and medium based on hospitalizing behaviors, and relates to the technical field of medical big data. The medical insurance fraud identification method comprises the steps S1 to S5. S1, medical data are obtained, and a medical abnormal picture is constructed according to the medical data. S2, sampling target patient nodes in the medical abnormal picture according to the behavior modes, and obtaining the behavior abnormal picture of each behavior mode of the target patient nodes. And S3, acquiring global topology embedding according to the medical abnormal picture. And S4, respectively carrying out aggregation in the behavior patterns on the target patient nodes in each behavior anomaly map through a two-step attention mechanism, and acquiring the behavior feature embedding of each behavior pattern of the target patient nodes. And then, the behavior characteristics of each behavior mode are embedded and guided by global topology embedding for fusion, and the final embedding of the target patient node is obtained. And S5, classifying according to the final embedding, and judging whether the target patient node is a medical insurance cheater.
PCI for CTO has dramatically changed in recent years. Although, with the improvement of devices and refinement of operator techniques, PCI of CTO can currently be performed with high success and low complication rates at experienced centers, the clinical benefit of recanalization of CTO is still a matter of debate. Accumulating evidence suggests that the improvement of left ventricular functional and prognosis is closely related with the area of viable myocardium, which has the potential for contractile recovery after revascularization. For the majority of interventional cardiologists, coronary angiography is the only invasive test deemed necessary for clinical decision-making, despite its weak ability to predict the functional impact of vascular occlusion on the subtended myocardium. To overcome this limitation, adjunctive diagnostic tools for functional evaluation, such as FFR, CFR, IMR and D-SPECT, have been introduced. In non-CTO patients, physiology-guided revascularization strategy has been definitely proven to be better than angiography-guided strategy in pivotal landmark studies. However, the clinical value of these functional parameters for the PCI of CTO is still unknown.

The aim of this study was to determine whether functional evaluation is a better predictor of clinical outcome in patients with CTO undergoing PCI.
AIM: To investigate changes in nitric oxide (NO) levels, oxidative stress, and dynamic thiol/disulphide homeostasis in the serum and cerebrospinal fluid (CSF) of patients with aneurysmal subarachnoid hemorrhages (aSAH).
MATERIAL AND METHODS: This prospective study included a total of 40 consecutive patients suffering from aSAH, who were operated on within the first 48 hours from onset of symptoms; CSF and blood samples were collected from these patients during their operations. To create a control group, blood samples and cerebrospinal fluid were taken from patients (n=40) without neurologic disorders who had undergone lumbar puncture for spinal anesthesia.
RESULTS: We observed that the serum total antioxidant status had decreased markedly (p=0.0143) but that no change was evident in the oxidative stress index and total oxidant status in aSAH patients when compared to the controls. While total thiol (p=0.0014) and native thiol (p < 0.0001) levels had decreased in the aSAH patients, disulphide levels (p < 0.0001) had increased significantly. Although the native thiol/total thiol ratio declined (p < 0.0001), the dynamic disulphide/total thiol ratio (p < 0.0001) and dynamic disulphide/native thiol ratio (p < 0.0001) increased markedly in serum samples from the patient group. Patient serum NO levels were also significantly elevated (p < 0.0001). There were no marked changes in CSF for all measured parameters (p > 0.05).
CONCLUSION: This study demonstrated that serum NO levels and oxidative stress parameters increased markedly in the patients. These results may help to understand the underlying mechanisms behind early tissue damage due to aSAH and to monitor disease progression and improve the early detection of disease severity.
Patients receive niraparib PO QD on days 1-21 of cycles 1-4, and on days 1-42 of subsequent cycles. Patients also receive dostarlimab IV over 30 minutes on day 1. Cycles repeat every 21 days for cycles 1-4 and every 42 days for subsequent cycles in the absence of disease progression or unacceptable toxicity.
The invention discloses a traditional Chinese medicine preparation for treating alcoholism and a preparation method of the traditional Chinese medicine preparation and belongs to the field of traditional Chinese medicines. The effective component of the traditional Chinese medicine disclosed by the invention comprises the following active ingredients in parts by weight: scandent hop, cordateleaf European hop flowers, kumquats, sticktight, small goosefoots, primula obconica, radix sophorae flavescentis, leaves of hovenia, tamarix chinensis, textile screw pine seeds, amomum tsao-ko, alpine swertia, Chinese honey locusts, chu-lan tree flowers or leaves, cimicifugae foetidae and coptis chinensis. The medicinal materials selected are appropriate in compatibility, so that the traditional Chinese medicine preparation has the double effects of treatment and conditioning. The traditional Chinese medicine preparation disclosed by the invention is drawn from nature, so that the traditional Chinese medicine preparation is free of toxic or side effects of chemical medicines and is safe to take. According to the traditional Chinese medicine preparation disclosed by the invention, drug resistance is not generated to bacteria, so that the human body is free of dependency on the traditional Chinese medicine preparation. The traditional Chinese medicine preparation disclosed by the invention has an obvious alcoholism-dispelling function and is an ideal preparation for health treatment of alcoholism and excess and alcoholic liver diseases.
Time to delay the initiation of anticoagulation is determined at randomization. The Time-To-Treatment Randomization of 324 (+/- 12) hours starts Day 14.
PURPOSE: An anti-obesity composition containing a Canavalia gladiata fermentation is provided to remarkably lower body weight. CONSTITUTION: An anti-obesity composition contains: a fermentation prepared by sealing a mixture of Canavalia gladiata and an ethanol solution and fermenting at room temperature(20-30°C) for 50-70 days; or a fermentation which is prepared by sealing the mixture at room temperature for 50-70 days, and maturing at low temperature(3~10°C) for 40-50 days. The composition additionally contains Zanthoxylum ailanthoides leaf extract. The ethanol solution contains 20-40%(v/v) of ethanol. The composition is a pharmaceutical or food composition. A composition for diet contains the fermentation as an active ingredient.
Individual balding scalps will be outlined and mapped to include up to 30 injection sites evenly distributed within the hair loss area. At each site, 5 Units of Xeomin® will be injected with a maximum of 150 Units total per subject. This will be a single, one-time treatment session.
FIELD: organic chemistry, medicine, phthisiology. SUBSTANCE: invention proposes novel combined antituberculosis agents. They represent the composition of derivatives of quinoxaline-1,4-dioxide of the formula (I)   where X means hydrogen atom, alkyl, alkoxy-group, halogen atom; R 1  and R mean hydrogen atom, alkyl, alkoxycarbonyl, carbamido-group, oxyalkyl, acyloxyalkyl known as antibacterial compounds (for example, dioxydin) with the known antituberculosis preparations. Effectiveness of the proposed composition is higher as compared with its separate components with regards to mycobacteria by 50-200 times. EFFECT: expanded arsenal of agents of claimed designation. 4 cl, 7 tbl
OBJECTIVE: Published evidence suggests that cognitive impairment during a TGA (transient global amnesia) spell may not be confined to episodic memory. We undertook a systematic review to determine the pattern of cognitive deficits during a TGA episode. As a secondary objective, we aimed to delineate the course of cognitive recovery.
METHODS: MEDLINE, EMBASE, CENTRAL, and Google scholar were systematically searched up to October 2023. Observational controlled studies including 10 or more TGA patients (Hodges and Warlow criteria) were retrieved. Data from case-control, cross-sectional, and cohort studies were reviewed and qualitatively synthesized.
RESULTS: Literature search yielded 1302 articles. After the screening of titles and abstracts, 115 full texts were retrieved and 17 of them were included in the present systematic review. During the acute phase, spatiotemporal disorientation, dense anterograde and variable retrograde amnesia, semantic memory retrieval difficulties, and working memory deficits comprised the neuropsychological profile of patients with TGA. Visuospatial abilities, attention and psychomotor speed, semantic memory, confrontation naming, and other measures of executive function (apart from semantic fluency and working memory) were consistently found normal. In the course of recovery, after the resolution of repetitive questioning, the restoration of spatiotemporal orientation follows, working memory and semantic memory retrieval ensue, while episodic memory impairment persists for longer. Meticulous evaluations may reveal subtle residual memory (especially recognition) deficits even after 24 h.
CONCLUSIONS: Μemory impairment, spatiotemporal disorientation, and working memory deficits constitute the pattern of cognitive impairment during a TGA spell. Residual memory deficits may persist even after 24 h.
Firstly sociodemographic and pre-test scale will be applied to all nurses who meet the inclusion criteria. The simulation scenario will be applied on the second day of the research. The scenario, prepared using the literature on child abuse, takes 10 minutes. In the scenario, there will be a staff nurse, a charge nurse, a child skills model, and a facilitator researcher in the role of the mother.The other two researchers, as independent observers, will monitor the achievement of the scenario objectives from the checklists.
This study aims to explore the pathogenesis of myocardial ischaemia reperfusion injury(MIRI) based on oxidative stress-mediated programmed cell death and the mechanism and targets of Chaihu Sanshen Capsules in treating MIRI via the protein kinase Cβ(PKCβⅡ)/NADPH oxidase 2(NOX2)/reactive oxygen species(ROS) signaling pathway. The rat model of MIRI was established by the ligation of the left anterior descending branch. Rats were randomized into 6 groups: sham group, model group, clinically equivalent-, high-dose Chaihu Sanshen Capsules groups, N-acetylcysteine group, and CGP53353 group. After drug administration for 7 consecutive days, the area of myocardial infarction in each group was measured. The pathological morphology of the myocardial tissue was observed by hematoxylin-eosin(HE) staining. The apoptosis in the myocardial tissue was observed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL). Enzyme-linked immunosorbent assay(ELISA) was employed to measure the le-vels of indicators of myocardial injury and oxidative stress. The level of ROS was detected by flow cytometry. The protein and mRNA levels of the related proteins in the myocardial tissue were determined by Western blot and real-time quantitative PCR(RT-qPCR), respectively. Compared with the sham group, the model group showed obvious myocardial infarction, myocardial structural disorders, interstitial edema and hemorrhage, presence of a large number of vacuoles, elevated levels of myocardial injury markers, myocardial apoptosis, ROS, and malondialdehyde(MDA), lowered superoxide dismutase(SOD) level, and up-regulated protein and mRNA le-vels of PKCβⅡ, NOX2, cysteinyl aspartate specific proteinase-3(caspase-3), and acyl-CoA synthetase long-chain family member 4(ACSL4) in the myocardial tissue. Compared with the model group, Chaihu Sanshen Capsules reduced the area of myocardial infarction, alleviated the pathological changes in the myocardial tissue, lowered the levels of myocardial injury and oxidative stress indicators and apoptosis, and down-regulated the mRNA and protein levels of PKCβⅡ, NOX2, caspase-3, and ACSL4 in the myocardial tissue. Chaihu Sanshen Capsules can inhibit oxidative stress and programmed cell death(apoptosis, ferroptosis) by regulating the PKCβⅡ/NOX2/ROS signaling pathway, thus mitigating myocardial ischemia reperfusion injury.
JNJ-54175446 is an unlicensed drug currently being developed by Janssen Pharmaceuticals. The drug is presented in oral capsules, each capsule containing 50 mg of JNJ-54175446. Participants will be asked to self-administer one capsule daily for 8 weeks.
PURPOSE: A composition containing a Rosa multiflora extract is provided to prevent hair loss, to promote hair growth, and scalp blood circulation, and to relieve scalp inflammation. CONSTITUTION: A composition for preventing hair loss and promoting hair growth contains a Rosa multiflora extract as an active ingredient. The composition additionally contains extracts of black soybeans, Puerariae radix, silk of Zea mays linne, burdock, or mugwort. The extract is prepared using water, low carbon number alcohol, ethyl acetate, hexane, chloroform, or acetonitrile. The composition is a cosmetic, food, or pharmaceutical composition. A cosmetic method for preventing hair loss and promoting hair growth comprises a step of applying or spraying the composition onto the scalp.
Prostanoids are mediators that have been implicated in all stages of inflammation. The inhibition of prostanoid synthesis by NSAIDs forms the basis of their therapeutic as well as side effects. NSAIDs directly inhibit cyclooxygenase \[COX\], which leads to reduction of prostaglandin synthesis and also to gastric erosions, inhibition of platelet aggregation and nephrotoxicity. The identification of the two isoforms of COX lead to the hypothesis that COX-2 is responsible for the production of prostaglandins following tissue injury, while COX-1 is involved in normal homeostasis.

The selective COX-2 inhibitors are believed to be efficacious anti-inflammatory drugs devoid of the side effects associated with the inhibition of COX-1. However, the selectivity of these drugs has only been demonstrated in vitro and ex vivo, which may not be a reliable indicator of the in vivo selectivity. The proposed study aims to evaluate the in vivo selectivity of celecoxib, a drug demonstrated to be a selective inhibitor of COX-2 in vitro in the oral surgery model of acute inflammation.
When the leading follicle is greater than 17 mm following ovulation induction with follicle stimulating hormone (FSH) daily injections, ovulation trigger injection will be given to the participant. 36 hours after ovulation trigger injection single intrauterine insemination with partner's sperm collected on the same day will be done.
PURPOSE:To provide new compounds showing an anticonvulsant effect, a chronotropic action and a bronchus relaxation effect and useful as a medical drug. CONSTITUTION:Compounds of formula I (R is H, aminoloweralkyl in which amino may be substituted or phenylloweralkyl in which phenyl may have substituent), e.g. 2,2-dimethyl-5-oxo-2,3,4,5-tetrahydro-8trifluoromethylpyrid[3,2- f][1,4]oxazepine. The compound of formula I can be obtained by reacting 3,4- dihydro-2,2-dimethyl-7-trifluoromethyl-2H-pyrano[2,3-b]pyridin-4-one of formula II with hydrazoic acid in the presence of an acid catalyst (e.g. sulfuric acid) in an inert solvent (e.g. chloroform) at an ice-cooling temperature.
PURPOSE:To provide a dental material having low odor and high water- resistance, and composed of a vinyl monomer having an aromatic group on the side chain and having a specific boiling point, an acrylic resin composed mainly of methyl methacrylate, and a polymerization initiator. CONSTITUTION:The objective dental material is composed of (A) a vinyl monomer having aromatic group on the side chain and having a boiling point of >=150 deg.C under 760 mmHg pressure, (B) an acrylic resin composed mainly of methyl methacrylate, and (C) a polymerization initiator. The preferable example of the component A is the compound of formula (R is H or CH3; m and n are 0-3), and the component B is preferably a copolymer containing >=20 wt% component A. The amounts of the components A and B are 20-50 wt% and 80-50 wt% based on the sum of both components, respectively, and the amount of the component C is 0.1-10 pts. wt. per 100 pts. wt. of A+B. The dental material can be used not only as a filler for cavity but also as a dental adhesive.
People with normal fasting glucose and normal fasting FFA (normal fasting glucose / normal glucose tolerance - NFG / NGT) will be studied on 2 occasions. On one occasion they will receive saline overnight and on the other they will receive intralipid and dextrose to raise fasting glucose and fasting FFA. Subsequently (on either study day) they will undergo a hyperglycemic clamp for 2 hours. After this somatostatin will be infused acutely to inhibit endogenous insulin secretion and observe clearance of beta-cell polypeptides.