(For children’s dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients.

Elderly Patients: In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reac­tions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully moni­tored and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients.

1.To Control Severe Nausea and Vomiting:  
Adjust dosage to the response of the individual. Begin with the lowest recommended dosage.  
Oral Dosage-Tablets: Usually one 5mg or 10mg tablet 3 or 4 times daily. Daily dosages above 40 mgs should be used only in resistant cases.

2.In Adult Psychiatric Disorders: Adjust dosage to the response of the individual and according to the severity of the condition. Begin with the lowest recom­mended dose. Although response ordinarily is seen within a day or 2, longer treatment is usually required before maximal improvement is seen.  
Oral Dosage: Non-Psychotic Anxiety--Usual dosage is 5 mg 3 or4 times daily. Do not administer in doses of more than 20mg per day or for longer than 12 weeks.

Psychotic Disorders including Schizophrenia\--Inrelatively mild conditions, as seen in private psychiatric practice or in out patient clinics, dosage is 5 or 10 mg 3 or 4 times daily.

In moderate to severe conditions, for hospitalized or adequate­ly supervised patients, usual starting dosage is 10 mg 3 or 4 times daily. Increase dosage gradually until symptoms are con­trolled or side effects become bothersome. When dosage is increased by small increments every 2 or 3 days, side effects either do not occur or are easily controlled. Some patients respond satisfactorily on 50 to 75mg daily. In more severe dis­turbances, optimum dosage is usually 100 to 150mg daily.

DOSAGE AND ADMINISTRATION--CHILDREN

Do not use in pediatric surgery.  
Children seem more prone to develop extrapyramidal reac­tions, even on moderate doses. Therefore, use lowest effec­tive dosage. Tell parents not to exceed prescribed dosage, since the possibility for adverse reactions increases as dosage rises. Occasionally the patient may react to the drug with signs of restlessness and excitement; if this occurs, do not administer additional doses. Take particular precaution in administering the drug to children with acute illnesses or dehydration (see under Dystonias).

1\. Severe Nausea and Vomiting in Children:  
Prochlorperazine should not be used in pediatric patients under 20 pounds in weight or 2 years of age. It should not be used in conditions for which children’s dosages have not been established. Dosage and frequency of administration should be adjusted according to the severity of the symptoms and the response of the patient. The duration of activity following intra­muscular administration may last up to 12 hours. Subsequent doses may be given by the same route if necessary.

Oral Dosage: More than 1 day’s therapy is seldom necessary.

2\. Children with schizophrenia:  
Oral Dosage: For children 2 to 12 years, starting dosage is 21/2 mg 2 or 3 times daily. Do not give more than 10 mg the first day. Then increase dosage according to patient’s response.  
  
FOR AGES 2 to 5, total daily dosage usually does not exceed 20mg.  
  
FOR AGES 6 to 12, total daily dosage usually does not exceed 25mg.