anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Intraoperative hypotension might contribute to the development of postoperative delirium through inadequate cerebral perfusion. However, evidence regarding the association between intraoperative hypotension and postoperative delirium is equivocal. Therefore, the hypothesis that intraoperative hypotension is associated with postoperative delirium in patients older than 70 yr having elective noncardiac surgery was tested .
METHODS: This was a retrospective cohort analysis of patients older than 70 yr who underwent elective noncardiac surgery in a single tertiary academic center between 2020 and 2021. Intraoperative hypotension was quantified as the area under a mean arterial pressure (MAP) threshold of 65 mmHg. Postoperative delirium was defined as a collapsed composite outcome including a positive 4 A's test during the initial 2 postoperative days, and/or delirium identification using the Chart-based Delirium Identification Instrument. The association between hypotension and postoperative delirium was assessed using multivariable logistic regression, adjusting for potential confounding variables. Several sensitivity analyses were performed using similar regression models.
RESULTS: In total, 2,352 patients were included (median age, 76 yr; 1,112 [47%] women; 1,166 [50%] American Society of Anesthesiologists Physical Status III or greater; 698 [31%] having high-risk surgeries). The median [interquartile range] intraoperative area under the curve below a threshold of MAP less than 65 mmHg was 28 [0, 103] mmHg · min. The overall incidence of postoperative delirium was 14% (327 of 2,352). After adjustment for potential confounding variables, hypotension was not associated with postoperative delirium. Compared to the first quartile of area under the curve below a threshold of MAP less than 65 mmHg, patients in the second, third, and fourth quartiles did not have more postoperative delirium, with adjusted odds ratios of 0.94 (95% CI, 0.64 to 1.36; P = 0.73), 0.95 (95% CI, 0.66 to 1.36; P = 0.78), and 0.95 (95% CI, 0.65 to 1.36; P = 0.78), respectively. Intraoperative hypotension was also not associated with postoperative delirium in any of the sensitivity and subgroup analyses performed.
CONCLUSIONS: To the extent of hypotension observed in our cohort, our results suggest that intraoperative hypotension is not associated with postoperative delirium in elderly patients having elective noncardiac surgery.
In some aspects, methods of detecting complement activation in vivo, e.g., in an eye, are provided. In some aspects, methods of detecting high risk drusen are provided. In some aspects, presence of one or more high risk drusen in an eye indicates increased likelihood of developing AMD, GA, or advanced AMD or increased likelihood of rapid progression of AMD. In some embodiments, methods comprise detecting drusen containing or in close proximity to complement activation. In some embodiments methods comprise detecting one or more drusen having inflamed endothelium underlying or in close proximity thereto. In some embodiments methods comprise detecting eye-derived extracellular microvesicles, e.g., exosomes, in a body fluid. In some embodiments methods comprise detecting Th17 cells or a Th17 biomarker in a body fluid. In some embodiments the Th17 biomarker is a cytokine. Methods may be applied individually or in any combination. In some embodiments any of the methods further comprises treating a subject at risk of developing AMD, GA, or advanced AMD or at increased likelihood of rapid progression of AMD with a complement inhibitor. In some aspects, agents useful for performing one or more of the methods are described.
PURPOSE:To prepare a makeup cosmetic exhibiting an excellent color-rendering property even under a light source having a low illuminance. CONSTITUTION:The makeup cosmetic contains mica titanium in an amount of 30-60wt.%, preferably 40-50wt.%. The mica titanium is obtained by applying the titanium on the surface of the mica. The cosmetic has a pearl luster tinged with various colors due to the interference action of the titanium coating. The color tone of the mica titanium is changed in response to the thickness of the titanium coating due to the color generation caused by the interference, and the titanium is preferably applied on the mica in an amount of 40-55wt.% based on the whole amount of the mica titanium. The mica titanium shows the pearl color tinged with a color ranging from a green color to a blue color. The cosmetic containing the mica titanium does not show a showy color even at a light place high in illuminance and has excellent cosmetic brilliance. The cosmetic is thereby highly useful as a cosmetic in a time low in the illuminance, such as a night.
Participants received roxadustat according to the tiered weight-based approach, with starting doses of 70 mg given thrice weekly (TIW) to participants weighing up to 70 kg and 100 mg given TIW to participants weighing more than 70 kg. Dose-titration was performed based upon regular measurement of Hb levels until participants achieved central Hb value of ≥ 11.0 g/dL and Hb increase from baseline (BL) of ≥ 1.0 g/dL at two consecutive study visits, separated by at least 5 days. Once target Hb level was reached participants entered maintenance period during which roxadustat dosage was adjusted every 4 weeks to maintain participants Hb level within the target range of 10.0 g/dL and 12.0 g/dL. Participants received roxadustat for at least 52 weeks up to a maximum of 104 weeks.
The investigators will recruit last year medical students and randomise them into two groups: Group A and Group B. Both groups will be video recorded during the performance of the two skills on simulators (i.s. Donati suture and intraosseous venous access) (timepoint: T0). Then group A will watch a standardised video about the skills, and group B will do self-study. Then, both groups will be again video recorded during the performance of the two skills on simulators (timepoint: T1). After 1 week group B will watch the same standardised video about the skills, and group A will do self-study. Then both groups will be again video recorded during the performance of the two skills on simulators (timepoint: T2).
Content delivery system that aggregates and delivers text, audio and video and other content to an end-user from a library of past and current content. A user can actively provide information to the system without utilizing multiple steps or the system can guide content creation from a content originator. A single or limited action content request from a user to the content originator simultaneously collects various information from the user without additional user action. The system collects implicit and explicit content from the source where a content originator can indicate content that should appear a delivery system which originates on other delivery systems. The system automatically reads content and assigns it to a specific category and allows the content originator to further edit said content. Content is delivered to a user through implicit and explicit triggers and excludes content or makes available content depending on user history and other variables.
The invention comprises a method of obtaining pure ascorbic acid by extraction with a twophase system, in starting from natural materials containing ascorbic acid, characterized in that leaves from a plant of the type Tucca Guatemalensis or Fourcroya Gigantea are subjected to grinding in a screw press, after said leaves have been cut up in fragments transversely to the direction of the fibres, then the resulting ground product is pressed in a hammer grinder; the juice obtained is subsequently treated for extraction of the ascorbic acid by way of a solvent system comprising two non-miscible phases, each formed by water, acetone and magnesium chloride; the extract is concentrated and purified by a treatment with acetic acid, lastly pure ascorbic acid is recovered from said extract.  In order to preserve the extracted juice, sodium hydrosulphite and xylol may be added in the preferred proportions of 7 g./l. of the former and 4 ccs./1. of the latter.  The two phases obtained by extraction are opposed in counter-current apparatus, and after concentration the ascorbic acid is crystallized from the upper phase.  Preferably the extraction is carried out in the temperature range 35-40 DEG  C. Alternatively, instead of crystallizing immediately ascorbic acid, subsequent to the step of extraction with water-acetone-magnesium chloride system, the phase containing the extracted ascorbic acid is subjected to a concentration bringing the acetone content to 50/55 per cent with respect to the water present and the phase so concentrated is then subjected to a new extraction with a two system comprising water, acetone and zinc sulphate.  The acetone which forms the lower phase extracts the ascorbic acid.
Patients will be divided into groups according to quartiles (25/50/75) of progesterone levels. Optimal range of progesterone levels for ongoing pregnancy rate will be calculated.
PURPOSE OF REVIEW: Pulmonary hypertension (PH) is commonly observed in premature infants with bronchopulmonary dysplasia (BPD) and is associated with poor outcomes and increased mortality. This review explores the management of this intricate condition of the pulmonary vasculature, which exhibits heterogeneous effects and may involve both arterial and postcapillary components.
RECENT FINDINGS: Current management of BPD-PH should focus on optimizing ventilatory support, which involves treatment of underlying lung disease, transitioning to a chronic phase ventilation strategy and evaluation of the airway. Data on management is limited to observational studies. Diuretics are considered a part of the initial management, particularly in infants with right ventricular dilation. In many cases, pulmonary vasodilator therapy is required to induce pulmonary arterial vasodilation, reduce right ventricular strain, and prevent coronary ischemia and heart failure. Echocardiography plays a pivotal role in guiding treatment decisions and monitoring disease progression.
SUMMARY: BPD-PH confers a heightened risk of mortality and long-term cardio-respiratory adverse outcomes. Echocardiography has been advocated for screening, while catheterization allows for confirmation in select more complex cases. Successful management of BPD-PH requires a multidisciplinary approach, focusing on optimizing BPD treatment and addressing underlying pathologies.
People with OUD co-occurring with depression or PTSD (COD) may not seek out treatment for their substance use or mental health issues, but they do visit their primary care provider. However, because providers generally lack specialized training in substance use and mental illness and are focused on the immediate reason for the visit, patients' substance use and mental disorders often go unrecognized and untreated. This missed opportunity can have lethal consequences. Individuals with COD are at higher risk of dying from suicide or overdose than individuals with mental illness or OUD alone. The parent study (NCT04559893) will provide a definitive answer as to whether collaborative care (CC) improves access, quality, and outcomes of care for individuals with COD. While a primary goal is to improve access to and retention in medication treatment for OUD (MOUD) (which is linked to decreased mortality and overdose risk), the interventions CC-COD supports do not proactively address suicide or overdose risk, an important limitation. In addition, CC-COD does not include families in the patient's care. The investigators address these limitations and tackle the public health crisis of increasing deaths from suicide and overdose with this study. Because family members can play an important role in a patient's decision to engage with treatment and in overdose and suicide prevention, the study team investigates family members' views and use this information to strengthen CC-COD. This revision will develop and then test the incremental effectiveness of three additional CC-COD components. Care coordinators will (1) educate family members about MOUD with the goal of increasing patient retention in treatment; (2) train family members and the patient to administer naloxone and on how to reduce overdose risk behaviors; and (3) implement Caring Contacts, a suicide prevention intervention that sends compassionate mailed or text messages to individuals to decrease social isolation and reduce suicide risk.
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. In preferred embodiments, the oligonucleotides are targeted to mRNA encoding human c-raf or human A-raf. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of detecting the presence of a raf gene using oligonucleotides of the invention, including methods for specific detection of activated truncated raf. Methods of inhibiting hyperproliferation of cells and methods of treating conditions arising from abnormal raf expression which employ oligonucleotides of the invention are also provided.
This is a randomized controlled clinical trial of 148 suicidal active-duty US Army Soldiers. Participants were randomized to on-site providers who were trained in the Collaborative Assessment and Management of Suicidality (CAMS) vs. providers doing their own routine care--referred to as Enhanced Care as Usual (E-CAU) within an outpatient military treatment center. The CAMS Rating Scale (CRS) was used to reliably verify fidelity between treatment conditions and the adherence by CAMS providers to the model. Participants received informed consent to be randomly assigned to treatment arm and were ask to complete study assessments at baseline, 3 months, 6 months, and 12 months after the start of treatment. Recruitment is complete and all study assessments were completed as of March 2016. The study is in a second year of no cost extension; outcome data analyses and moderator analyses are currently underway to develop manuscripts for submission to peer-review scientific journals.
In certain embodiments, an expression construct is provided that contains a tissue-specific promoter such as tyrosinase linked to one or more cytotoxin genes. The cytotoxin genes may be saporin genes. In certain embodiments, a vector is provided that contains an expression construct as discussed above. The vector may be an adeno-associated virus or an adenovirus. Further, neural stem cells may be provided that contain and/or produce a vector, which in turn contains an expression construct containing a tissue-specific promoter linked to one or more cytotoxin genes. In certain embodiments, methods of using the neural stem cells provided herein for production and delivery of an animal virus vector are provided. Methods for treating melanomas in a subject in need thereof are also provided by delivering an expression construct that contains a tissue-specific promoter linked to one or more cytotoxins. In certain embodiments, the melanoma is metastatic, and in certain embodiments the melanoma is a brain melanoma.
<P>PROBLEM TO BE SOLVED: To provide a method for making liposomes, [for example multivesicular liposomes (MVL)], containing one or more biologically active agents.  <P>SOLUTION: The loading of the active agents into the liposomes is modulated by adjusting the osmolarity of the aqueous component into which the agents are dissolved prior to encapsulation. To increase the loading of the active agent, the osmolarity of the aqueous component is reduced, and to decrease the loading of the active agent, the osmolarity of the aqueous component is increased. In the making of MVL, the process involves dissolving the active agent and an optional osmotic excipient in a first aqueous component encapsulated within the liposomes. For any given concentration of drug, the osmolarity of the first aqueous component can be adjusted by increasing or decreasing the concentration or molecular weight of the osmotic excipients used therein. The rate of release of the active agent into the surrounding environment in which the liposomes are introduced can be simultaneously controlled by incorporating into the lipid component used in the formulation at least one long chain amphipathic lipid.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Extraction more particularly to a kind of extra large asparagus general flavone and polysaccharide combined extraction method the present invention relates to active components of plants, include the following steps：S1. extra large asparagus, cleaning, dry, crushing, sieving, obtains extra large asparagus dry powder；S2. it weighs dry powder and adds in distilled water, adjust pH value, digested under the conditions of addition complex enzyme vacuum tightness, extract, centrifuge, supernatant a and filter residue is obtained by filtration；S3. supernatant a is taken to concentrate, extract liquor extraction detaches to obtain supernatant b；S4. supernatant b is concentrated, adds ethyl alcohol, extracted, centrifuge, supernatant c and deposit is obtained by filtration, by concentrating, being dried to obtain general flavone crude product；S5. it is adsorbed by macroporous resin column, ethanol elution, collects eluent, concentrate, be dried to obtain Refined flavonoid powder；S6. deposit by enzyme process removing protein, dialyse, be dried to obtain refined polysaccharide.Present invention process is simple, easy to operate, and the time is short, and effectively removes chlorophyll, salinity and other miscellaneous point, improves the yield and product purity of general flavone and polysaccharide.
Bilateral superficial cervical plexus block has successfully been demonstrated to provide an efficient analgesia in patients with thyroidectomy, parathyroidectomy, carotis end-arterectomy. The present study is aimed to investigate the intraoperative hemodynamic responses, anesthetic and analgesic consumption, and postoperative recovery quality of bilateral superficial cervical plexus block in patients with total thyroidectomy. After approval, patients enrolled in the study is invited to complete the Pain Catastrophizing Scale questionnaire. Patients are divided into two groups by computer-based randomization technique as control and study group. After standard monitorization, anesthesia induction and tracheal intubation, bilateral superficial cervical plexus block is performed to study group and no intervention to control group. At the end of the operation all patients received paracetamol 1 gr intravenous. In postoperative period, visual analog scale values, opioid consumption, presence of nausea-vomiting, anti-emetic usage or any other complications are recorded.
Humanized anti-CD3 bispecific binding molecules having reduced immunogenicity are provided. Humanized antibody constructs derived from OKT3 in the format of bispecific binding molecules can have reduced specific activities and related antibody-derived compounds having reduced side-effects that are useful in the treatment of human diseases are derisible. Accordingly, there is provided a bispecific binding molecule having a first domain which contains a humanized antibody-derived light chain that specifically binds to/interacts with the human CD3 complex. The bispecific binding molecule has a second domain which contains a different antigen-interaction-site or an effector domain. Specific amino acid substitutions in light chain of OKT3 ¨ specifically at Ser24, Val54 and Leu96 according to the Kabat system ¨ in the first domain of the bispecific binding molecule result in the humanization, reduced immunogenicity, and enhanced cytotoxicity. Uses, methods, compositions, cells and vectors relating thereto are also described.
Macrodantin is a larger crystal form of Furadantin® (nitrofurantoin). The absorption of Macrodantin is slower and its excretion somewhat less when compared to Furadantin. Blood concentrations at therapeutic dosage are usually low. It is highly soluble in urine, to which it may impart a brown color.

Following a dose regimen of 100 mg q.i.d. for 7 days, average urinary drug recoveries (0 to 24 hours) on day 1 and day 7 were 37.9% and 35.0%.

Unlike many drugs, the presence of food or agents delaying gastric emptying can increase the bioavailability of Macrodantin, presumably by allowing better dissolution in gastric juices.
BACKGROUND: This study's objective is to describe outcomes of adult patients who underwent thoracic stent graft placement treatment for primary or recurrent aortic coarctation.
METHODS: This is a retrospective study of 30 adult patients who underwent thoracic stent graft placement for aortic coarctation at our institution. Average age was 46.5 years, with 53.3% of patients presented with no prior treatment or repair for coarctation. Indications for repair included gradient ≥20 mm Hg with anatomic evidence of coarctation on imaging with left ventricular hypertrophy, pseudoaneurysm, aneurysm, refractory hypertension, or claudication. Stent grafts used for repair included MDT (Medtronic, Santa Rosa, CA) and GORE TAG (W. L. Gore & Associates, Flagstaff, AZ).
RESULTS: Patients were observed for a median of 979 days, with one death during the study. All patients had complete resolution of symptoms with no recurrences. Thoracic endovascular aortic repair significantly reduced the gradient across the coarctation (P < 0.0001). Aortic coarctation diameter significantly increased at 30 days postoperatively and continued to increase up to 5 years posttreatment. At 3+ years, aortic remodeling was observed at the coarctation site and surrounding regions. At 30 days, systolic, diastolic, and mean arterial pressure were all reduced. Systolic and diastolic blood pressure and mean arterial pressure continued to significantly improve 1-year posttreatment.
CONCLUSIONS: Stent grafts are a safe and effective treatment for aortic coarctation. We observed a clinically significant improvement in blood pressure and longitudinal aortic remodeling of the coarctation segment and the entire aorta that persisted more than more than 3 years.
This is a multicenter (approximately 10 - 14 sites), prospective, non-randomized study. The study is designed to evaluate the safety and effectiveness of the sirolimus-eluting Bx VELOCITYTM stent in patients with de novo native coronary artery lesions. A total of 100 patients will be entered in the study. Patients who meet the eligibility criteria will be enrolled into the study. Patients will be followed at 30 days, 6, 9, and 12 months, and at 2, 3, 4 and 5 years post-procedure, with all patients undergoing repeat angiography at 6 months. Approximately 50 patients will be required to have an intravascular ultrasound (IVUS) procedure at baseline and at the 6-month angiographic follow-up.