anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
To more appropriately support communication between a pharmacist and a patient.SOLUTION: In an information processing system 1, a prescription data acquisition part 51 of a computer 10 for a pharmacy acquires prescription data of a patient. A prescription data transmission part 52 transmits the prescription data to a server 20. A change point acquisition part 155 of the server 20 acquires change point medicine information on medicines changed by past prescription contents and prescription contents of this time on the basis of the prescription data and past prescription data of the patient. A change point data transmission part 156 transmits data of the change point medicine information to a terminal 30 for a pharmacist. A screen display part 254 of the terminal 30 for a pharmacist displays a screen for presenting information of medicines related to a prescription including the change point medicine information to the patient on the basis of the data of the change point medicine information. An operation reception part 251 receives an operation inputted to the screen. The screen display part 254 changes display contents of information of medicines in accordance with the operation.SELECTED DRAWING: Figure 1
In the genomic era, the availability of gene panel and whole genome/exome sequencing is rapidly increasing. Opportunities for providing former patients with new genetic information are also increasing over time and recontacting former patients with new information is likely to become more common. Breast cancer Refined Analysis of Sequence Tests-Risk And Penetrance (BRA-STRAP) is an Australian study of individuals who had previously undertaken BRCA1 and BRCA2 genetic testing, with no pathogenic variants detected. Using a waiver of consent, stored DNA samples were retested using a breast/ovarian cancer gene panel and clinically significant results returned to the patient (or next of kin, if deceased). This qualitative study aimed to explore patient experiences, opinions, and expectations of recontacting in the Australian hereditary cancer setting. Participants were familial cancer clinic patients (or next of kin) who were notified of a new pathogenic variant identified via BRA-STRAP. In-depth, semi-structured interviews were conducted approximately 6 weeks post-result. Interviews were transcribed verbatim and analyzed using an inductive thematic approach. Thirty participants (all female; average age = 57; range 36-84) were interviewed. Twenty-five were probands, and five were next of kin. Most women reported initial shock upon being recontacted with unexpected news, after having obtained a sense of closure related to their initial genetic testing experiences and cancer diagnosis. For most, this initial distress was short-lived, followed by a process of readjustment, meaning-making and adaptation that was facilitated by perceived clinical and personal utility of the information. Women were overall satisfied with the waiver of consent approach and recontacting process. Results are in line with previous studies suggesting that patients have positive attitudes about recontacting. Women in this study valued new genetic information gained from retesting and were satisfied with the BRA-STRAP recontact model. Practice implications to facilitate readjustment and promote psychosocial adaptation were identified.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, ophthalmology, and can be used for treating latent subretinal neovascular membranes. That is ensured by introduction of the vascular endothelial growth factor inhibitor ranibizumab in dosage 0.3-0.5 mg transsclerally in the posterior vitreous body. In 5-7 days after reduction of neovessel permeability and tissue oedema, a neovascular membrane is sized by fluorescent angiography. Further, the photosensitiser Verteporfin 0.08-0.1 mg/kg is administered. In 15 min, the neovessels within SNM borders are exposed to a diode laser of wave length 689 nm at power density 500-600 mWt/cm2 for 83-100 seconds in total dosage to 50 J/cm2. ^ EFFECT: method allows improving visual functions, reducing retinal damages, lowering possibility of recurrent neovascularisation, improving life quality in the rehabilitation period. ^ 2 ex
In trials of alcohol-dependent subjects, 2.6% (n=26) of subjects were >65 years of age, and one patient was >75 years of age. Clinical studies of VIVITROL did not include sufficient numbers of subjects age 65 and over to determine whether they respond differently from younger subjects. No subjects over age 65 were included in studies of opioid-dependent subjects. The pharmacokinetics of VIVITROL have not been evaluated in the geriatric population. 

This drug is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, it may be useful to monitor renal function.
Squamous cell carcinoma (SCC) of the tongue is the most prevalent form of oral cavity cancer, with surgical intervention as the preferred method of treatment. Achieving negative or free resection margins of at least 5 mm is associated with improved local control and prolonged survival. Nonetheless, margins that are close (1-5 mm) or positive (less than 1 mm) are often observed in practice, especially for the deep margins. Ultrasound is a promising tool for assessing the depth of invasion, providing non-invasive, real-time imaging for accurate evaluation. We conducted a clinical trial using a novel portable 3D ultrasound imaging technique to assess ex vivo surgical margin assessment in the operating room. During the operation, resected surgical specimens underwent 3D ultrasound scanning. Four head and neck surgeons measured the surgical margins (deep, medial, and lateral) and tumor area on the 3D ultrasound volume. These results were then compared with the histopathology findings evaluated by two head and neck pathologists. Six patients diagnosed with tongue SCC (three T1 stage and three T2 stage) were enrolled for a consecutive cohort. The margin status was correctly categorized as free by 3D ultrasound in five cases, and one case with a "free" margin status was incorrectly categorized by 3D ultrasound as a "close" margin. The Pearson correlation between ultrasound and histopathology was 0.7 (p < 0.001), 0.6 (p < 0.001), and 0.3 (p < 0.05) for deep, medial, and lateral margin measurements, respectively. Bland-Altman analysis compared the mean difference and 95% limits of agreement (LOA) for deep margin measurement by 3D ultrasound and histopathology, with a mean difference of 0.7 mm (SD 1.15 mm). This clinical trial found that 3D ultrasound is accurate in deep margin measurements. The implementation of intraoperative 3D ultrasound imaging of surgical specimens may improve the number of free margins after tongue cancer treatment.
The patients who did not prefer the block and preferred intravenous patient-controlled analgesia (PCA) are named as Group II (n=45). IV PCA is prepared with morphine 0.5 mg/ml.
OBJECTIVE: To compare ultrasonography-guided drainage versus conventional surgical incision and drainage in deep neck space abscesses.
METHODS: The study was pre-registered on the National Institute of Health Research Prospective Register of Systematic Reviews (CRD42023466809) and adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Medline, Embase and Central databases were searched. Primary outcomes were length of hospital stay and recurrence. Heterogeneity and bias risk were assessed, and a fixed-effects model was applied.
RESULTS: Of 646 screened articles, 7 studies enrolling 384 participants were included. Ultrasonography-guided drainage was associated with a significantly shorter hospital stay (mean difference = -2.31, p < 0.00001), but no statistically significant difference was noted in recurrence rate compared to incision and drainage (odds ratio = 2.02, p = 0.21). Ultrasonography-guided drainage appeared to be associated with cost savings and better cosmetic outcomes.
CONCLUSION: Ultrasonography-guided drainage was associated with a shorter hospital stay, making it a viable and perhaps more cost-effective alternative. More randomised trials with adequate outcomes reporting are recommended to optimise the available evidence.
A cosmetic agent, preferably a hair oil, comprising, in a cosmetically acceptable carrier, a) one or more alkanes from the group of undecane, dodecane, tridecane; b) at least one ester oil from the group of dicarboxylic acid esters, carbonate esters and diol esters, and; c) crambe abyssinica seed oil. Preferably, the alkane component comprises two, most preferably three, of C11-C13 linear alkanes. Preferably, the composition further comprises an ester oil from the group of tri-fatty acid esters based on glycerol. Preferably, the composition further comprises isopropyl myristate. Preferably, b) is selected from esters of carbonic acid with fatty alcohols; most preferably, the at least one ester oil b) comprises dicaprylyl carbonate. Preferably, the composition is free from silicones. The agent, which comprises Abyssinian oil, may be used for the care of keratin fibres. The hair oil may also comprise perfume. Crambe abyssinica seed oil comprises seed oil from the plant crambe abyssinica, which also referred to as Abyssinian Kale.
One aspect of the invention is a new foam with particles suspended therein. Another aspect of the invention is a foaming component for use in association with a foam dispenser. The foaming component includes an air sparging element, a mixing chamber, and an air chamber. The mixing chamber is on one side of the air sparging element and it defines a portion of the mixing chamber. The air chamber is on the other side of the air sparging element and it defines a portion of the air chamber. The air chamber has an air inlet. The mixing chamber has a liquid inlet and an outlet, and the outlet is down stream of the inlet. The foaming component also forms part of a new foam dispenser. The foaming component and the foam dispenser are for use in the production of foam with a plurality of particles suspended therein.
PURPOSE: During malarial infection, both parasites and host red blood cells (RBCs) come under severe oxidative stress due to the production of free radicals. The host system responds in protecting the RBCs against the oxidative damage caused by these free radicals by producing antioxidants. In this study, we investigated the antioxidant enzyme; superoxide dismutase (SOD) activity and cytokine interactions with parasitaemia in Ghanaian children with severe and uncomplicated malaria.
METHODOLOGY: One hundred and fifty participants aged 0-12 years were administered with structured questionnaires. Active case finding approach was used in participating hospitals to identify and interview cases before treatment was applied. Blood samples were taken from each participant and used to quantify malaria parasitaemia, measure haematological parameters and SOD activity. Cytokine levels were measured by commercial ELISA kits. DNA comet assay was used to evaluate the extent of parasite DNA damage due to oxidative stress.
RESULTS: Seventy - Nine (79) and Twenty- Six (26) participants who were positive with malaria parasites were categorized as severe (56.75 × 103 ± 57.69 parasites/µl) and uncomplicated malaria (5.87 × 103 ± 2.87 parasites/µl) respectively, showing significant difference in parasitaemia (p < 0.0001). Significant negative correlation was found between parasitaemia and SOD activity levels among severe malaria study participants (p = 0.0428). Difference in cytokine levels (IL-10) amongst the control, uncomplicated and severe malaria groups was significant (p < 0.0001). The IFN-γ/IL-10 /TNF-α/IL-10 ratio differed significantly between the malaria infected and non- malaria infected study participants. DNA comet assay revealed damage to Plasmodium parasite DNA.
CONCLUSION: Critical roles played by SOD activity and cytokines as anti-parasitic defense during P. falciparum malaria infection in children were established.
Start propranolol+pyridostigmine 10mg bid +30mg bid, and then dose up to 20mg bid+30mg bid. if tolerable.
FIELD: medicine. SUBSTANCE: method involves exposing 7-8% of total circulating blood volume to ultraviolet radiation and subjecting the irradiated blood to centrifugal plasmapheresis with following 1 ml of adenosine triphosphoric acid and single antibiotic dose added to the cell mass. After being incubated, the produced mixture is brought back through dropper to patient blood circulation. Total treatment course is 4-6 sessions long, with 48 h intervals separating the sessions. EFFECT: enhanced effectiveness of treatment; low doses of antibiotics. 2 tbl
In principle, risk-stratification as a routine part of the NHS breast screening programme (NHS-BSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE (National Institute of Health and Care Excellence) approved more frequent screening and/ or chemoprevention to be realised for women who are at increased risk, but are unaware of this. The invesigators have developed BC-Predict, which is offered to women when invited to NHS-BSP and collects information on risk factors (self-reported information on family history and hormone-related factors, mammographic density and in a sub-sample, Single Nucleotide Polymorphisms). BC-Predict then produces risk feedback letters, and invites women at moderate or high risk to have discussion of prevention and early detection options at Family History, Risk and Prevention Clinics. Key objectives of the present research are to quantify important potential benefits and harms, and to identify the key drivers of the relative cost-effectiveness of embedding BC-Predict into NHS-BSP.

A non-randomised fully counterbalanced study design will be used, to include equal numbers of participants from five screening sites who will be offered NHS-BSP and BC-Predict. Specifically, in the initial 8-month time period, women eligible for NHS-BSP in three screening sites will be offered BC-Predict, whilst women in two screening sites are offered usual NHS-BSP. In the following 8-month time period the study sites switch their offers. In total 16000 women will be invited to BC-Predict, and compared with 16000 women offered standard NHS-BSP. Key potential benefits including uptake of BC-Predict, risk consultations, chemoprevention and additional screening will be obtained from NHS-BSP and Family History, Risk and Prevention Clinic records for both groups. Key potential harms such as increased anxiety will be obtained via self-report questionnaires. Health economic analyses will identify the key uncertainties underpinning the relative cost-effectiveness of embedding BC-Predict into NHS-BSP.
IN BRIEF: Females with obesity may experience infertility and can improve their fertility through exercise. This review found that most exercise interventions improve fertility outcomes regardless of technique, intensity, or duration. More detailed reporting through the lens of exercise prescription should be included in future studies.
ABSTRACT: Female infertility disproportionately affects people with obesity. Exercise often improves fertility outcomes for this population, however, there is limited prescriptive evidence. Specifically, there is a lack of information on the ideal type, frequency, intensity, and setting of exercise to improve fertility outcomes. Using principles of exercise prescription, this review aimed to describe the scope of exercise interventions that have been explored and fertility outcomes measured for people with female infertility and obesity. A search was completed in PubMed, Embase, Cochrane, and CINAHL, identifying 16 relevant published articles. Overall, exercise had a positive impact on female fertility outcomes in people with obesity, though there were large variations in the exercise interventions prescribed and outcomes measured. Cyclic exercise (i.e. walking and cycling) was the most common technique incorporated, though a combination of cyclic, acyclic (i.e. circuit training and boot camp), or individualization was often used. Several fertility outcomes were reported; however, the rate of conception, pregnancy, and live birth rates were the most common, which, we suggest, should always be reported in fertility intervention research. We stress that future studies provide more thorough descriptions of their implemented exercise interventions to facilitate reproducibility and comparisons between studies. Closer attention to the principles of exercise prescription when developing and reporting exercise interventions will help improve fertility outcomes, mainly live birth rates, for those with female infertility and obesity.
The invention discloses a traditional Chinese medicine composition for treating lymph cancer and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from, by weight, 6-11 parts of pericarpium citri reticulatae viride, 9-13 parts of pteris cretica L. var. nervosa (Thunb.) Ching et S. H. Wu, 7-12 parts of silybum marianum, 8-13 parts of whiteflowered bittercress root, 5-9 parts of cornu cervi degelatinatum, 10-14 parts of tassel of Zea mays L., 7-13 parts of hydrocotyle sibthorpioides, 3-6 parts of concha ostreae, 4-10 parts of root of Meconopsis chelidonifolia Bur. et Franch., 8-14 parts of ricepaperplant root, 9-15 parts of dandelion, 7-11 parts of oyster plant inflorescence, 5-10 parts of bulbus fritillariae thunbergii, 6-12 parts of oval kumquat root, 9-14 parts of fructus tritici levis and 3-9 parts of semen aesculi. The traditional Chinese medicine composition for treating the lymph cancer has the advantages that the traditional Chinese medicine composition is free of side effects and safe to take, normal body functions of a patient cannot be damaged after the patient takes the traditional Chinese medicine composition for a long time, the traditional Chinese medicine composition is not limited to the lesions of the cancer and can also correct body immune disorders and effectively remove the relapse and metastasis factors of tumor, cancer cells are killed while normal tissue cells are protected, the body immunity of the patient is enhanced, and the traditional Chinese medicine composition is low in treatment cost, free of dependence and drug resistance and evident in curative effect.
Patients treated with ropinirole havereported falling asleep while engaged in activities of daily living, including the operation ofmotor vehicles, which sometimes resulted in accidents. Although many of these patients reportedsomnolence while on ropinirole, some perceived that they had no warning signs such as excessivedrowsiness, and believed that they were alert immediately prior to the event. Some of theseevents have been reported as late as 1 year after initiation of treatment.

In controlled clinical trials, somnolence was a common occurrence in patients receivingropinirole and is more frequent in Parkinson's disease (up to 40% ropinirole, 6% placebo) than inRestless Legs Syndrome (12% ropinirole, 6% placebo). Many clinical experts believe that fallingasleep while engaged in activities of daily living always occurs in a setting of preexistingsomnolence, although patients may not give such a history. For this reason, prescribers shouldcontinually reassess patients for drowsiness or sleepiness, especially since some of the events occur well after the start of treatment. Prescribers should also be aware that patients may notacknowledge drowsiness or sleepiness until directly questioned about drowsiness or sleepinessduring specific activities.

Before initiating treatment with ropinirole, patients should be advised of the potential to develop drowsiness and specifically asked about factors that may increase the risk with ropinirole such as concomitant sedating medications, the presence of sleep disorders (other than RestlessLegs Syndrome), and concomitant medications that increase ropinirole plasma levels (e.g.,ciprofloxacin—see PRECAUTIONS: Drug Interactions). If a patient develops significantdaytime sleepiness or episodes of falling asleep during activities that require active participation(e.g., conversations, eating, etc.), ropinirole should ordinarily be discontinued. (See DOSAGE AND ADMINISTRATION for guidance in discontinuing ropinirole.) If a decision is made tocontinue ropinirole, patients should be advised to not drive and to avoid other potentiallydangerous activities. There is insufficient information to establish that dose reduction willeliminate episodes of falling asleep while engaged in activities of daily living.
Thirty patients who underwent pancreatic resection for pancreatic neoplasm were prospectively randomized. Perioperative blood glucose levels were continuously monitored using an artificial endocrine pancreas (STG-22). Glucose levels were controlled using either the sliding scale method or the artificial pancreas.
The in vitro detection of circulating tumor cells (CTCs) has been proven as a vital method for early diagnosis and evaluation of cancer metastasis, since the existence and number fluctuation of CTCs have shown close correlation with clinical outcomes. However, it remains difficult and technically challenging to realize accurate CTCs detection, due to the rarity of CTCs in the blood samples with complex components. Herein, we reported a CTCs in vitro detection strategy, utilizing a loop amplification strategy based on DNA tetrahedron and nicking endonuclease reaction, as well as the anti-background interference based on lanthanide metal luminescence strategy. In this work, a detection system (ATDN-MLLPs) composed of an aptamer-functionalized tetrahedral DNA nanostructure (ATDN) and magnetic lanthanide luminescent particles (MLLPs) was developed. ATDN targeted the tumor cells via aptamer-antigen recognition and extended three hybridizable target DNA segments from the apex of a DNA tetrahedron to pair with probe DNA on MLLPs. Then, the nicking endonuclease (Nt.BbvCI) recognized the formed double-strand DNA and nicked the probe DNA to release the target DNA for recycling, and the released TbNps served as a high signal-to-noise ratio fluorescence signal source for CTCs detection. With a detection limit of 5 cells/mL, CTCs were selectively screened throughout a linear response range of low orders of magnitude. In addition, the ATDN-MLLPs system was attempted to detect possible existence of CTCs in biological samples in vitro.
[PROBLEMS] To provide a novel agent for the prevention or treatment of leukemia. [MEANS FOR SOLVING PROBLEMS] Disclosed is an agent for the prevention or treatment of leukemia, which comprises at least a composition derived from an olive leaf. Also disclosed is a beverage/food for the prevention or treatment of leukemia, which comprises at least the composition. The composition can inhibit the proliferation of a leukemia cell and can also induce the differentiation of a leukemia cell into a leukocyte (a normal cell). Therefore, the agent and the beverage/food can be used for the prevention or treatment of leukemia with high possibility. The agent and the beverage/food has such additional advantages that they may be applied over a long period and continuously with high possibility, that they may have few adverse side-effects with high possibility, and the like.
Patients to carry out an experimental double ovarian stimulation and to receive 4 weekly injections of Corifollitropin alfa. Prospective group.