anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The Bioequivalence study of Klaribact Suspension will be conducted on 24 healthy participants. Finally selected subjects will be divided into two groups, Group A and Group B, with 12 subjects in each group. The study will be consisted of two periods, Period I and Period II, each comprising of 35 hours, 11 hours before and 24 hours after the drug administration. A washout period of 6 days will be provided between the two periods to ensure the absence of carry over effect. Each group (A \& B) will be treated with either of the two sequences, TR or RT, in Period I and the sequence will be inter-changed in Period II. blood samples from each volunteer will be collected at specific time points to analyze plasma concentration of Clarithromycin.
The present invention relates to a method for augmenting data, which may augment sparsely annotated video frame sequences. The method for augmenting data may comprise: a step of acquiring a first image and a first label; a step of determining a relation between the first image and a second image; and a step of generating a third image and a second label based on the relation between the first image and the second image. The second image has a time sequential relation with the first image. The third image is generated by propagating the first image based on a motion vector field. The first image is a part of image frames having a cycle. A size of propagated step of the propagation is smaller than the cycle.
Pharmacists' roles in cachexia care are unclear. This study aimed to clarify the knowledge and practice of cachexia care and identify factors related to the practice of cachexia care among pharmacists. Information on the knowledge and practice of cachexia care was obtained. Components of practicing multimodal care were evaluated. Participants were categorized into two groups according to practicing multimodal care levels. Comparisons were made between the groups, and multiple regression analysis was employed. Of the 451 pharmacists, 243 responded. They were categorized into the Practicing group (n = 119) and Not practicing group (n = 124). Significant differences were observed for the number of advanced cancer patients/month, frequency of caring for them, and involvement in training programs on cachexia. The Practicing group had significantly better knowledge about cachexia. The Practicing group used guidelines, items, and symptoms more frequently to detect cachexia. The Practicing group tended to detect cachexia and initiate interventions in earlier phases and in patients with a better status. Multivariate logistic regression analysis showed that the most significant factor was the regular provision of care (odds ratio, 2.07; 95% confidence interval, 1.10-3.92). The regular provision of care was associated with the practice of multimodal care.
Irish patients with low Von Willebrand levels will be have both venous blood sampling and a bleeding score administered at study entry. A DDAVP (1-desamino-8-D-arginine vasopressin) fall off study was organised for those patients in the cohort with no previous fall offs available and no contraindications to DDAVP.
<P>PROBLEM TO BE SOLVED: To provide an X-ray image diagnostic system and a portable recording medium which facilitate the management of history of radiation exposure during medical treatment and make radiation dose history data available even in an environment where systems are not attached to a network.  <P>SOLUTION: The X-ray image diagnostic system (an X-ray CT apparatus 1) accumulates radiation dose history data in a radiation dose history controlling database 127 at each examination. A system controller 124 displays a list of groups of radiation dose history data which are stored in the radiation dose history controlling database 127 according to a radiation dose history viewer application (a viewer 128). The system controller 124 writes the viewer 128 and the groups of radiation dose history data on a portable medium M1. An external terminal 2 reads the portable medium M1 by its media drive 203 and implements the viewer 128. Then it can display the radiation dose history data which is stored in the portable medium M1.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Rheumatoid arthritis (RA) is an auto-immune disorder described by permanent inflammation of the articular synovial membrane. Non-treated RA can cause gradual joint damage, ending in complaint, poor lifestyle, and an upright ratio of death. Approximately one percent of the people are involved, and the disorder begins, in general, appears during the third and fifth decades of age, with more occurrences in females. The treatment is complicated as well as involves various stages of medications with variable methods of application as well as non-pharmacologic methods. The extra prevalent are disease person's culture, then, sports and mechanical and behavioral therapy. Due to more chance of ischemic heart disease, trials should be increased to lessen the assisting behaviors such as cigarette smoking, high lipid profile, elevation of blood pressure, and high body mass index.
Many lactic acid bacteria (LAB), known for their human health benefits, are derived from milk and utilized in biotherapeutic applications or for producing valuable nutraceuticals. However, the specific role of milk-associated LAB in biotherapeutics remains underexplored. To address this, eight milk product samples were randomly selected from the Egyptian market, diluted, and then cultured anaerobically on MRS agar. Subsequently, 16 suspected LAB isolates were recovered and underwent rapid preliminary identification. Among these isolates, the Lactobacillus plantarum strain with accession number (OQ547261.1) was identified due to its strong antioxidant activity depending on the DPPH assay, L. plantarum displayed notable antioxidant activities of 71.8% and 93.8% at concentrations of 125-1000 µg/mL, respectively. While ascorbic acid showed lower concentrations of 7.81, 3.9, and 1.95 µg/mL which showed activities of 45.1%, 34.2%, and 27.2%, respectively. The anti-inflammatory efficacy of L. plantarum was evaluated based on its capability to prevent hemolysis induced by hypotonic conditions. At a concentration of 1000 µg/mL, L. plantarum could reduce hemolysis by 97.7%, nearly matching the 99.5% inhibition rate achieved by the standard drug, indomethacin, at an identical concentration. Moreover, L. plantarum exhibited high hemolytic activity at 100 µg/mL (14.3%), which decreased to 1.4% at 1000 µg/mL. The abundance of phenolic acids and flavonoids was determined by high-performance liquid chromatography (HPLC) in L. plantarum. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) demonstrated that L. plantarum increased gene expression of the inflammatory marker TLR2 by 133%, and cellular oxidation markers SOD1 and SOD2 by 65% and 74.2%, respectively, while suppressing CRP expression by 33.3%. These results underscore L. plantarum's exceptional anti-inflammatory and antioxidant activities. Furthermore, L. plantarum induces cancer cell death through necrotic nuclear DNA fragmentation. These findings suggest that L. plantarum is not only suitable for nutraceutical production but also holds potential as a probiotic strain. Future research should focus on enhancing the capacity of this strain across various industries and fostering innovation in multiple fields.
The app is designed by our team by a broadband (500-3000 Hz) click sound of 30-40 dB for soft sound/whisper and 60-70dB for loud sound/conversation voice. This app is designed by the Flutter-Dart programming tool and the speaker is produced via hand-held devices of Apple and Android brands. The tone is produced 3 times, with 2 out of 3 answers are considered as the patient's hearing threshold. The examiner stands at the distance of 2 feet away behind the seated patient and a soft sound from the FFCT is tested. The patient is then asked to respond yes or to nod if able to hear the sound. When the patient is unable to answer or no response is received upon thrice testing, the examiner then moves closer to 6 inches to the patient and again the soft sound is tested thrice. Loud sound is then tested if the patient is unable to respond, starting from 2 feet distance for three times. And then, the loud sound is tested at 6 inches of distance if no further response is obtained.
1. A cDNA sequence   encoding mammaglobin polypeptide, or a derivative thereof having the analogue function. 2. A sequence derivative of claim 1, wherein comprises the sequence, complementary to SEQ ID NO: 1 or a derivative thereof. 3. The mammaglobin polypeptide with an amino acid sequence:   or a derivative thereof. 4. The method for detecting the presence of breast cancer in a patient comprising detecting and/or quantitating the presence of a mRNA encoding a mammaglobin polypeptide of claim 3 in a sample from the patient, comprising incubating the sequence of claim 2 with the sample under conditions in which said mRNA can specifically hybridize with cDNA, wherein an elevated concentration of said hybridized complex above the concentration for a healthy individual indicates the presence of breast cancer cells. 5. The method for detecting the presence of breast cancer in a patient comprising detecting and/or quantitating the presence of a mRNA encoding a mammaglobin polypeptide in a sample from the patient, wherein said mammaglobin polypeptide comprises using the reverse transcription method , of said mRNA to obtain cDNA, amplifying the cDNA region by the polymerase chain reaction method using the two primers, complementary to the flanking regions of said c DNA region, and detecting the amplified cDNA region, wherein the elevated concentration of said amplified cDNA region above the concentration for a healthy individual indicates the presence of breast cancer cells. 6. The method of claim 5, the primers comprise:   7. A kit of claim 4, wherein comprises a sample comprising the sequence of claim 2 packaged in a container. 8. A kit of claim 5, wherein comprises two primers for the polymerase chain reaction packeged in a container. 9. A kit of claim 8, wherein two primers comprise:   10. A method for detecting the presence of breast cancer in a patient which comprises detecting the presence of a mammaglobin polypeptide of claim 3 in a sample comprising incubating an antibody to said mammaglobin polypeptide of claim 3 or to a mammaglobin epitope comprising at least five amino acids with said sample under conditions in which said antibody can bind with the mammaglobin polypeptide, and detecting the complex antibody-polypeptide, wherein wherein the elevated concentration of said complex above the concentration for a healthy individual indicates the presence of breast cancer cells. 11. The method of claim 10 wherein the antibody is a polyclonal antibody and the mammaglobin epitope comprises:   12. The method of claim 10 wherein the antibody is a monoclonal antibody and the mammaglobin epitope comprises:   13. A kit of claim 10 comprising an antibody to said mammaglobin polypeptide of claim 3 or the mammaglobin epitope comprising at least five amino acids packeged in a container. 14. The kit of claim 13 wherein said antibody is a monoclonal antibody and the mammaglobin epitope comprises:   15. The kit of claim 13, wherein said antibody is a polyclonal antibody and the mammaglobin epitope comprises:
Approximately 190 patients ≥ 65 years of age participated in clinical studies with mirtazapine. Mirtazapine tablets are known to be substantially excreted by the kidney (75%), and the risk of decreased clearance of this drug is greater in patients with impaired renal function. Pharmacokinetic studies revealed a decreased clearance of mirtazapine in the elderly [see Clinical Pharmacology (12.3)]. 

Sedating drugs, including mirtazapine tablets, may cause confusion and over-sedation in the elderly. Elderly patients may be at greater risk of developing hyponatremia. Caution is indicated when administering mirtazapine tablets to elderly patients [see Warnings and Precautions (5.12), (5.15) and Clinical Pharmacology (12.3)]. In general, dose selection for an elderly patient should be conservative, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
FIELD: medicine; cosmetology. 
     SUBSTANCE: invention refers to medicine, namely to cosmetology and dermatology, and can be used for treating acne. Perform complex therapy sessions carried out in sessions every second day. Thus 1st session includes cleansing the skin with antiseptic gel, vaporization, manual cleaning, processing with antiseptic lotion, darsonvalization performance, point and lymphatic drainage massage and the subsequent application of anti-inflammatory mask, and then - a protective cream or serum, cryomassage application. 2nd session after skin cleansing includes application of specified anti-inflammatory mask and subsequent application of mask with dissolving and exfoliating action, implementation of massage, darsonvalization and cryomassage performance and skin treatment at bedtime in the area of acne using therapeutic lotion. 3rd session after skin cleansing includes application of anti-inflammatory mask, antiseptic mask and darsonvalization and cryomassage performance locally on the affected elements. While at the 2nd session, after the application of mask with dissolving and exfoliating action, with its subsequent rinsing and drying of the skin perform therapeutic facial massage. To do this perform nine sequentially executed steps. Thus 1st stage includes stroking of the chin, cheeks, forehead. 2nd stage involves kneading the forehead, cheeks and chin. 3-ND stage includes pincer fulling of chin and cheeks, including along vertical lines, - from the middle of the chin to the nose wings; from the middle from beneath the angle of lower part of the jaw to the middle of the cheek; from the angle of the lower jaw bone - to the lateral surface of the cheeks. 3rd stage if finished using the "Snail" technique, consisting in the implementation of sixteen deep pinches from the lateral surface of the cheek in a downward direction, passing through the edge of the lower jaw, spinning along a spiral line to the middle of the cheek. 4th stage comprises circular grinding with circular and spiral movements. 5th stage includes forehead kneading along vertical lines. 6th stage involves light patting movements, “stacatto" on the forehead, cheeks and chin. 7th stage involves a deep vibration pinches, including ones along vertical lines of the lower part of the face. 7th stage if finished using the "Snail" technique. 8th stage is the same as 4th. 9th stage involves stroking; massage is done with light pressure on temples with both hands. 
     EFFECT: method provides more efficient treatment, deep skin cleansing, elimination of inflammation, elimination of infection, elimination of toxins and impurities, full recovery of skin functions by achieving a stable therapeutic effect, improvement of blood circulation in the subcutaneous capillaries, acceleration of metabolic processes in the skin affected by acne due to the deeper and more intensive effect in conducting therapeutic massage. 
     3 cl, 5 ex
Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer. Methylation of some genes plays a crucial role in the tendency to malignancy as well as poor prognosis of thyroid cancer, suggesting that methylation features can serve as complementary markers for molecular diagnosis. In this study, we aimed to develop and validate a diagnostic model for PTC based on DNA methylation markers. A total of 142 thyroid nodule tissue samples containing 84 cases of PTC and 58 cases of thyroid adenoma (TA) were collected for reduced representation bisulfite sequencing (RRBS) and subsequent analysis. The diagnostic model was constructed by the logistic regression (LR) method followed by 5-cross validation and based on 94 tissue methylation haplotype block (MHB) markers. The model achieved an area under the receiver operating characteristic curve (AUROC) of 0.974 (95% CI, 0.964-0.981) on 108 training samples and 0.917 (95% CI, 0.864-0.973) on 27 independent testing samples. The diagnostic model scores showed significantly high in males (P = 0.0016), age ≤ 45 years (P = 0.026), high body mass index (BMI) (P = 0.040), lymph node metastasis (P = 0.00052) and larger nodules (P = 0.0017) in the PTC group, and the risk score of this diagnostic model showed significantly high in recurrent PTC group (P = 0.0005). These results suggest that the diagnostic model can be expected to be a powerful tool for PTC diagnosis and there are more potential clinical applications of methylation markers to be excavated.
Participants enrolled in the study will receive a G6 e-cigarette at V2 for ad libitum use. After the first week of e-cigarette use, (at V3) participants will be given zonisamide and bupropion in addition to continued use of the G6. Use of these study drugs will continue for 12- weeks with a target complete switch date (from combustible cigarettes to e-cigarettes) one week after study drug initiation.
The present invention concerns a complex comprising an active agent, a polymer and an iron oxide nanoparticle. The complex may also comprise an active agent. Also described are methods of releasing an active agent from the complex, for instance by irradiating the complex with radio waves. Also described are compositions and articles comprising the complex. Also described are methods of therapy and particularly methods of treatment of cancer involving the complex described herein. In addition, the invention concerns a polymer which is particularly useful in preparing the complex described herein. The polymer is capable of undergoing a phase change at a predetermined temperature, such as 39-42° C. In one embodiment, the polymer is a copolymer of N-isopropylacrylamide, acrylic acid and acrolein. In another embodiment, the polymer is a copolymer of N-isopropylacrylamide acrylamide and allyl mercaptan.
Our primary aim is to explore the effect of compression socks during running on delayed onset muscle soreness after running. Our secondary aims are to explore the effects of compression socks during running on perceived recovery, perceived exertion, affective response, and heart rate after running. This is a randomised, double-blind, sham-controlled crossover trial. Forty-four participants will be recruited via social media, running clubs and the running coaches' network of the research team. Participants will be randomised to complete a running protocol under two conditions (compression socks or sham socks). After that, there will be a wash-out period of 7 to 10 days, and participants will repeat the running protocol under the other conditions. Primary outcome: lower limb muscle soreness will be collected, using a 0-100 numerical pain scale, immediately, 24 hours and 48 hours after the running protocol, with 24 hours post-protocol being the primary timepoint. Secondary outcomes: perceived recovery will be collected, using a 0-10 scale immediately, 24 hours and 48 hours after the running protocol. Perceived exertion, affective response, and heart rate will be registered only immediately after the protocol. Between-group differences will be explored using linear mixed models.
Intervention: Cognitive-Behavioral PCBT consists of 12 weekly visits of individual treatment. PCBT is designed to remediate deficits in skills for coping with interpersonal (e.g., social pressure, conflict with others) and intrapersonal (e.g., craving, anger) antecedents to drinking. The treatment consists of 6 mandatory modules (e.g., managing cravings) plus 6 electives from a list of 10 (e.g., receiving criticism; scheduling pleasant activities).The treatment, based on manuals developed for our previous clinical research provides a structured experience using didactic presentations, behavioral rehearsal, and homework practice exercises.
Understanding the capacity of temperate trees to acclimate to limited soil water has become essential in the face of increasing drought risk due to climate change. We documented seasonal - or phenological - patterns in acclimation to water deficit stress in stems and leaves of tree species spanning the angiosperm phylogeny. Over 3 yr of field observations carried out in two US arboreta, we measured stem vulnerability to embolism (36 individuals of 7 Species) and turgor loss point (119 individuals of 27 species) over the growing season. We also conducted a growth chamber experiment on 20 individuals of one species to assess the mechanistic relationship between soil water restriction and acclimation. In three-quarters of species measured, plants became less vulnerable to embolism and/or loss of turgor over the growing season. We were able to stimulate this acclimatory effect by withholding water in the growth chamber experiment. Temperate angiosperms are capable of acclimation to soil water deficit stress, showing maximum vulnerability to soil water deficits following budbreak and becoming more resilient to damage over the course of the growing season or in response to simulated drought. The species-specific tempo and extent of this acclimatory potential constitutes preadaptive climate change resilience.
Patients were randomly assigned to two anesthesia groups: opioid-containing (n=20) or opioid-free (n=20). The opioid used in the opioid-containing anesthesia group was fentanyl.
A multiplexing system and method for conveying simultaneously a multiplicity of communication channels over a single transmission medium. Multiplexing is effected by transforming a digital bit stream of each respective incoming channel into a corresponding prime frequency information stream and transmitting all of the prime frequency information streams over the single transmission medium. Digital bit streams carried on each incoming channel entering the system are in the form of binary “on” and “off” bits. These digital bits are converted into a corresponding information stream at a prime frequency component. Each prime frequency information stream is rendered distinctive and non-interfering with other prime frequency information streams during simultaneous transmission over the common medium due to the unique and heretofore unexploited mathematical properties of prime numbers. Expanded bandwidth is accomplished by grouping the prime frequency information streams into “chords” of disharmonic frequencies, and then transmitting the chord, composed of several discordant prime frequency information streams, over the single transmission medium.
Trametinib 2.0mg PO daily in 28-day cycles. A maximum of two trametinib dose level reductions are allowed (1.5mg and 1mg) in the case of adverse reactions.
Neonates assigned to the CPAP group were initiated on a pressure of 5 cmH2O. CPAP can be raised in steps of 1 cmH2O up to 8 cmH2O. If this is not enough to maintain SpO2 between 90% and 95%, FiO2 will be added up to 0.40.