anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The purpose of the proposed study is to examine, on a preliminary basis, the feasibility of a monitoring and intervention system that will enable the identification and even improvement of ineffective (and even harmful) hours of therapy in dynamic psychotherapy.

The study will take place in the clinic complex located at the Shalvata Mental Health Center campus (Shalva clinic, departmental follow-up clinics, day department), and will include 10 therapists (psychiatrists, psychologists, social workers) and 10 patients.The duration of the study will be two months. Once the patient and the therapist have signed an informed consent form, they will be integrated into a cellular-based routine outcome monitoring (ROM) that is developed specifically for the present study. This system, which is completely separate from the clinical systems of the Center, is operated after each session by the therapist. Its activation sends an SMS to the patient and to the therapist, in which a referral to a designated and secure site in which questionnaires are administered in order to measure the patient's condition and the assessment of the therapist and the patient regarding the quality of the therapeutic session. In addition, during the entire study period, the hours of treatment will be recorded in a dedicated manual recording device. This is done routinely in many research institutes in Israel and around the world, with the aim of approving the analysis of inefficient or harmful treatment hours. Treatment hours based on ROM data that have a negative effect (ie, evaluated negatively by the patient) will be transcribed by the therapist, and will undergo full MATRIX analysis. In each treatment pair, an analysis of up to two hours will be possible throughout the four months of the study. This analysis includes the conversion of the text to MATRIX codes, 3-letter codes that mark the section speaker (patient or therapist), the subject of the section (patient, therapist, or both) and its character (whether it deals with the ability to experience \[ , Or the relationship between experiences \[interrelation\]). The coding will be performed by the principal investigator or by the secondary investigator. After the encoding analysis, a MATRIX-based feedback will be given by the Principal Investigator to the therapist, in which the recommendations of the analysis will be submitted.

The proposed study combines routine conventional follow-up practices (ROM) in psychotherapy with innovative analysis tools (MATRIX), and seeks to be a first and significant step in addressing the urgent need to implement managed care in psychotherapy. This has far-reaching implications for the management of mental health care in community, clinic, day care and hospitalization units.
Chronic hepatitis B (CHB) infection continues to be an important health problem due to its high morbidity and mortality. For this reason, it is very important to determine the appropriate timing to start antiviral therapy in patients with CHB infection and to evaluate the stage of liver fibrosis in the treatment follow-up. Liver biopsy is the gold standard for detecting liver fibrosis. Although it is generally accepted to be a safe procedure, it can cause some serious complications. For this reason, in recent years, many studies have been conducted on new noninvasive tests in the evaluation of liver fibrosis. One of them is the serum regucalcin level. Studies have shown that serum regucalcin levels increase in liver damage, but there is no study in the literature comparing liver fibrosis and serum regucalcin levels in CHB infection. This study, it was aimed to investigate the relationship between serum regucalcin level and liver fibrosis level in patients with CHB infection.
BACKGROUND: Iliofemoral venous stent placement (IVS) has evolved to a well-established endovascular treatment modality for chronic iliofemoral venous obstruction (CIVO). Dedicated venous stents gained approval from the US Food and Drug Administration in 2019 and solidified IVS as a defined intervention with clear indications, contraindications, risks, benefits, and procedural management principles. This review focuses on the indications, technical aspects and outcomes of stenting for CIVO. Other aspects pertaining to IVS are covered in other articles that are a part of this series.
METHODS: This study conducted a literature search limited to English articles. Three search strategies were used, and references were managed in Covidence software. Four investigators screened and evaluated articles independently, excluding meta-analyses, clinical trial protocols, and nonrelevant studies. Eligible studies, focused on clinical outcomes and stent patencies, underwent thorough review.
RESULTS: The literature search yielded 1704 studies, with 147 meeting eligibility criteria after screening and evaluation. Exclusions were based on duplicates, irrelevant content, and noniliac vein stent placement.
CONCLUSIONS: Successful IVS for CIVO relies on meticulous patient selection, consistent use of intravascular ultrasound examination during procedures and attention to the technical details of IVS.
INTRODUCTION AND OBJECTIVE: Several studies have suggested that the hospitalization rate for COVID-19 in children and adolescents may reflect the prevalence of the infection rather than the severity of the disease. The aim of this study was to describe the clinical features of hospitalised paediatric patients with SARS-CoV-2 infection in order to understand if the infection was the reason for admission.
METHODS: Retrospective cohort study including patients aged 0-18 years with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) admitted to a tertiary care children's hospital in Spain between 01/01/2020 and 12/31/2021.
RESULTS: 228 patients were included, corresponding to 150 cases of COVID-related admission (SARS-CoV-2 infection as main cause of hospitalization) and 78 of non-COVID-related admission (SARS-CoV-2 infection unrelated to the hospitalization). In the group of COVID-related admissions, 58 patients had comorbidities. Forty-nine patients had acute respiratory disease (pneumonia, bronchospasm or bronchiolitis). Multisystem inflammatory syndrome in children was diagnosed in 27 and was significantly more frequent in the first year of the pandemic (wild type virus). Eighty percent of patients with acute respiratory disease needed respiratory support, mostly low-flow oxygen therapy. The severity of the disease was similar in all virus variants. Two patients (both with severe comorbidities) died from COVID-related conditions.
CONCLUSIONS: In our study, one third of the patients were admitted with SARS-CoV-2 infection but not because of it. Acute respiratory disease was less frequent and had a better prognosis compared to the adult population, while MIS-C was a major cause of morbidity and hospitalization. The fatality rate was extremely low.
Participants diagnosed with stroke will be evaluated with the Box and Block Test, 360 degree rotation test and 5 times squat test. These tests will be presented to the participants first in the real world and then in virtual reality.
BACKGROUND: Patients with dysplasia of the hip (DDH) have different degrees of bone defects above and outside the acetabulum, and anatomically reconstructing the acetabular centre of rotation is difficult in primary total hip arthroplasty (THA).
METHODS: From April 2012 to December 2022, 64 patients (64 hips) with DDH treated with THA with structural bone graft in the superolateral acetabulum were selected. The Oxford hip score(OHS), Barthel index (BI), leg length discrepancy, Wibegr central edge-angle(CE), gluteus medius muscle strength, vertical and horizontal distance of the hip rotation center, coverage rate of the bone graft and complications were used to evaluate the clinical effectiveness of the patients.
RESULTS: All patients were followed up for an average of 7.3±1.9 years. The OHS improved significantly after the operation (P<0.001). The postoperative BI was significantly greater than that before operation (P<0.001). The postoperative leg length discrepancy was significantly lower than that before the operation (P<0.001). Postoperative bedside photography revealed that the height and horizontal distance to the hip rotation center were significantly lower after surgery than before surgery (P<0.001). The postoperative CE was significantly greater than that before surgery (P<0.001). No acetabular component loosening or bone graft resorption was found during the postoperative imaging examination.
CONCLUSIONS: The use of biological acetabular cup combined with structural bone graft in the superolateral acetabulum in THA for DDH can obtain satisfactory medium and long-term clinical and radiological results.
Antroquinonol (Hocena) 50mg/capsule. 1 capsules antroquinonol and 1 capsule placebo, once a day.
BACKGROUND: Alarmins resulting from cell death or oxidative stress are involved in the development of Kawasaki disease (KD) vasculitis. In a previous study, we demonstrated the potential role of interleukin (IL)-33 as an alarmin in the development of KD vasculitis. Although edematous dissociation (necrotic change) of the tunica media is thought to be a major source of IL-33 in KD vasculitis, it has not yet been elucidated.
METHODS AND RESULTS: We investigated the impact of IL-33 released from necrotic human coronary artery smooth muscle cells (HCASMCs) on human coronary artery endothelial cells (HCAECs) using a coculture assay. Subsequently, we evaluated the anti-inflammatory effects of anti-IL-33 and anti-suppression of tumorigenicity 2 (ST2) antibodies compared with conventional therapies of KD, such as high-dose IgG or anti-tumor necrosis factor (TNF)-α antibody. Primary necrosis of HCASMCs induced significant release of IL-33. In cocultures of necrotic HCASMCs with HCAECs, the necrotic HCASMCs significantly induced the production of various proinflammatory cytokines in the HCAECs. Anti-IL-33 and anti-ST2 antibodies exhibited unique inhibitory effects on the production of platelet-derived growth factor-BB or IL-12(p70) in HCAECs.
CONCLUSIONS: There is potential involvement of edematous dissociation of the tunica media in the development of KD vasculitis. Furthermore, the distinctive anti-inflammatory effects of the anti-IL-33/ST2 axis drugs suggest novel therapeutic options for patients with refractory KD.
The invention relates to an extraction method of pterocarpus indicus, wherein the pterocarpus indicus is pterocarpus indicus of Dalbergia of Leguminosae, and Dalbergia sissoo Roxb; the extract comprises alcohol extract, ether extract, and petroleum ether extract; the monomer separated from the extract is 4-methoxyflavonolide (4-methoxydalberginone). The method specifically comprises the following steps: slicing lignum Dalbergiae Odoriferae core, pulverizing, sieving with No. 2 sieve, extracting with ethanol or methanol solution at a ratio of 1: 2-1: 8, and reflux-extracting under heating for 2-5 times (each for 1-3 hr). Filtering while hot, combining the filtrates, and concentrating under reduced pressure to obtain a diluted extract. The cell experiments prove that the Indian yellow sandalwood has important medicinal value. The monomer can obviously inhibit the proliferation of human liver cancer cell HepG2, human breast cancer cell MCF-7, mouse breast cancer cell 4T1 and human glioma cell U87, and influence the morphological function of the cells. Provides a basis for the development and utilization of the Indian yellow sandalwood and provides a new choice for the research and development of the anti-tumor drugs.
The present disclosure provides the use of Lactobacillus paracasei subsp. paracasei K56 in enhancing resistance of the intestinal tract to bacterial infection and improving intestinal immunity. Particularly, the present disclosure provides the use of a Lactobacillus paracasei subsp. paracasei in the preparation of a composition for improving intestinal immunity, wherein the Lactobacillus paracasei subsp. paracasei has a deposit number of CGMCC 15139 or DSM 27447. The present inventors have discovered that this bacteria strain alone can significantly improve the resistance of the intestinal tract to bacterial infection, combat invasion by pathogenic bacteria in the intestinal system, maintain the intestinal barrier function, and/or prevent diarrhea caused by pathogenic bacteria.
Based on the observation that African Americans are vastly more likely than their white and Hispanic counterparts to be infected by the human immunodeficiency virus (HIV), the Centers for Disease Control and Prevention (CDC) has termed AIDS a "health crisis" for African Americans and has called for a heightened national response to this glaring racial disparity. The crisis is especially dramatic in the Southern United States. Thus, the search for effective interventions tailored to this population is a national priority. This study expands upon a previous study conducted among young African American men. In the previous study we developed and tested the efficacy of a brief, clinic-based, program designed to interactively promote safer sex for African American men (18 to 29 years of age) engaging in sex with women. Adjusted findings from the previous study provided relatively robust support for program efficacy, with men who received the intervention program being about two-thirds less likely, than controls, to acquire an STI during a 6-month period. This study expands on the work performed in the previous study by developing and testing a version for younger African American males (i.e., teen males).

The purpose of this study is to test the efficacy of a brief, clinic-based and theory-guided, intervention designed to reduce STI incidence among African American teen (15 to 20 years old) males presenting themselves for STI testing.
For ASD patients, studies training facial emotion recognition have focused on increasing the active attention to the eye region, re-directing attention to facial features to facilitate facial emotion recognition. Evidence shows positive results using computer-based emotion recognition training programs with young children and adolescents with ASD. It has also been recently suggested that emotion recognition training may be a suitable intervention for patients with CD. This would be supported by some preliminary evidence in patients with severe behavioural problems, young offenders and patients with CD + CU Traits. The overall goal of this project is to investigate the compared impact of an emotion recognition training in patients with ASD or CD. This goal can be subdivided into three separate subgoals: a) identify whether the training program is effective; b) identify whether the training program has differentiated or comparable effects between both patients groups and c) investigate individual characteristics that may help identify those individuals who would benefit most from the intervention. This information is crucial to inform the design of more efficient treatments to differentially address the specific deficits associated to the disorders.
As the population of Singapore ages rapidly, cognitive decline associated with both normal aging and disease is becoming a frequently encountered health challenge. In our proposed study, we will investigate the effects of mindfulness-based interventions (MBI), which have shown significant promise in halting and even reversing age-related cognitive impairment. MBI enhances the quality and frequency of mindfulness, defined as a mental state achieved by focusing one's attention and awareness on the present moment, while calmly acknowledging and accepting one's feelings, thoughts, and bodily sensations. In this study, we will administer a standardized MBI program or Cognitive Rehabilitation Therapy to a group of 60 patients diagnosed with mild cognitive impairment (MCI), a condition marked by deficits in language, memory and attention that often leads to dementia; an additional 30 patients will be assigned to the control group. There will be 3 runs with 30 persons per run; each group will have 10 randomly assigned participants. By comparing the 3 groups across the 3 runs, we seek to test the following hypotheses: 1) MBI will result in significantly greater improvements in neuropsychological testing outcomes across multiple cognitive domains, including attention, memory, language and processing speed, 2) MBI will strengthen cortical connectivity as measured by functional magnetic resonance imaging (fMRI), and 3) MBI will lead to changes in fMRI activation on a test of facets of attention. Neuropsychological testing will take place in SGH, while fMRI and EEG scanning will take place in the Center for Cognitive Neuroscience at Duke-NUS. Both the MBI and CRT will be facilitated by trained personnel. Our proposed experiment comprises one of the most comprehensive interrogations of the effects of MBT on patients to date, and if successful, could rapidly translate into a program with both clinical and economic impact.
This is a multicenter, open-label, dose-escalated phase Ib study aimed to evaluate the safety, tolerability, and efficacy of JMT101 combined with afatinib in patients with advanced esophageal squamous cell carcinoma who have failed standard treatment. This study consists of two stages: dose-escalation stage and dose expansion stage. The dose-escalation stage will be conducted to determine the maximum tolerated dose (MTD) of JMT101 combined with afatinib in patients with advanced esophageal squamous cell carcinoma based on a 3+3 design. JMT101 will be given by intravenous infusion at 6 mg/kg (q2w) of each 28-week cycle. Afatinib will be sequentially administered at 30 mg and 40 mg (qd) of each 28-week cycle. One dose cohort which is verified to be well-tolerated and safe in dose-escalation stage will be selected for dose-expansion to further explore the safety, pharmacokinetic and efficacy of the study drug.
An oral preparation contains a water-soluble chlorophyll compound and a higher aliphatic acyl amide of an amino carboxylic acid having 12 to 16 carbon atoms in the higher acyl radical and 2 to 6 carbon atoms in the aliphatic portion of the amino carboxylic acid compound.  The amide may be of formula:  <FORM:0758216/VI/1> where R-CO is a saturated fatty acyl radical containing 12 to 16 carbon atoms e.g. dodecanoyl, tetra and hexadecanoyl radicals; R1 is a hydrogen atom or a lower alkyl group containing 1 to 6 carbon atoms; and X is a hydrogen atom or a cation which forms water-soluble salts e.g. sodium, potassium, ammonium, guanidine, mono-, di- or triethanolamine.  The chlorophyll compound e.g. sodium or potassium copper-, sodium or potassium magnesium-, or sodium iron chlorophyllin, or sodium potassium copper chlorophyll, may be present up to one per cent by weight and the amide up to 5 per cent by weight of the preparation; the ratio by weight of chlorophyll compound to amide being from 1 : 500 to 1 : 2. Suitable amino acids from which the amides may be derived are glycine, sarcasine, alanine, valine, and 3-aminopropanoic acid and specified amides are sodium or potassium N-lauroyl sarcaside and N-lauroyl sarcasine, N-myristoyl sarcaside, N-palmitoyl sarcaside, and N-lauroyl glycide.  The preparation may take the form of toothpaste, cream or powder, liquid dentifrice, mouthwash or tablet.  The pH of the preparation is between 5 and 10.  Other substances which may be present are ethyl alcohol, glycerine, sorbitol, propylene glycol, polyvinylpyrrolidone, sodium carboxymethylcellulose, gum tragacanth, starch, saccharine, urea, bentonite, calcium carbonate, magnesium carbonate, aluminium hydroxide, diammonium phosphate, di and tri-calcium phosphate, alkali metal salts of pyro-, tripoly- and tetraphosphoric acids, ethylene diamine tetracetic and citric acids.
Mucin-producing adenocarcinomas (MAC) are an extremely rare, indistinct group of neoplasm having either a salivary gland origin or with prominent glandular component. The diagnosis is chiefly based on the histological aspect conjoined with immunohistochemical evaluation as clinico-radiographical features are non-specific. It can arise as a primary metastasis to soft tissues, most commonly from either lung, breast, kidney, or colon. This paper reports a 51-year-old woman with buccolingual gingival swelling having a final diagnosis of metastatic mucinous adenocarcinoma from the breast. A tissue biopsy was performed followed by immunohistochemistry that confirmed the diagnosis. They are extremely rare, making the diagnosis challenging as it may mimic a benign neoplasm. It accounts for approximately 1% of all oral malignant neoplasms having gingival propensity. The clinician should therefore take into account every diagnostic aspect while encountering such oral lesions to achieve proper patient welfare.
PURPOSE:To obtain a keratin fiber-dyeing composition containing a specific triaminopyrimidin derivative used as a color-developing substance and a coupling substance and capable of dissolving in relatively low pH and readily preparing and excellent in dyeing effect. CONSTITUTION:The objective composition for dyeing a keratin fiber such as hair is obtained by using 2,4,5-triamino-6-chloropyrimidine of the formula or its salt as a color-developing substance in the composition consisting of a coupling substance and the color-developing substance. As the coupling substance, resorcin, 4-propyl-2,6-diaminopyridine, etc., is used. In the composition, a blend amount of the color-developing substance and the coupling substance is preferably about 1-3wt.%. When dyeing is carried out using the dyeing composition, wide dyeing, e.g. from yellow through red to blue and further from gray to black brown is made possible in the combination of the color substance and coupling substance. The color tone has high chroma. The resultant dyed color exhibits resistance to discoloration by light, washing, abrasion, etc.
The high burden of disease and the long-lasting sequelae following Streptococcus pyogenes (Strep A) infections make the development of an effective vaccine a global health priority. Streptolysin O (SLO), is a key toxin in the complex pathogenesis of Strep A infection. Antibodies are elicited against SLO after natural exposure and represent a key target for vaccine-induced immunity. Here we present the setup and characterization of a hemolysis assay to measure functionality of anti-SLO antibodies in human sera. Assay specificity, precision, linearity, reproducibility, and repeatability were determined. The assay was demonstrated to be highly sensitive, specific, reproducible, linear and performed well in assessing functionality of anti-SLO antibodies induced by exposed individuals. Moreover, different sources of critical reagents, in particular red- blood cells, have been compared and had minimal impact on assay performance. The assay presented here has throughput suitable for evaluating sera in vaccine clinical trials and sero-epidemiological studies to gain further insights into the functionality of infection- and vaccine-induced antibodies.