anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Opioid-switching participants are defined as those who had moderate to severe cancer pain that is controlled sufficiently with opioid therapy. Treatment period comprises of Titration and Maintenance period. Titration period (3-14 days) is duration between start of treatment to day before initial dose in maintenance period. Initial dose of tapentadol PR is selected according to daily dose of opioid (morphine sustained release \[SR\] preparation, oxycodone hydrochloride \[HCl\] SR tablet or fentanyl patch). Equivalent dose of tapentadol PR oral tablet twice daily is given depending on daily dose of opioid at completion of Screening period. Maximum dose limit is 500 mg per day. Participants will then be assigned to treatment in maintenance period (15-19 days). Maintenance period is defined as duration between first dose and final assessment in maintenance period. Participants will receive tapentadol PR oral tablet twice daily for 5 days at same dose used on last day of titration period.
All patients were premedicated with oral midazolam 7,5 mg and then they were induced into general endotracheal anesthesia according to a standardized protocol, with propofol 1-3 mg/kg, fentanyl 1-2 ug/kg and rocuronium bromide 0.6 mg/kg. Anaesthesia was continued with sevoflurane or desflurane MAC 1 to maintain mean arterial pressure with a value of +/- 20% of the original value. The epidural sufentanil infusion was started with bolus during anesthesia and continued after surgery as long as was necessary.
BACKGROUND AND AIM: The correct time to perform an upper endoscopy is decisive in acutely GI bleeding patients. However, patients' physical status may affect mortality. We speculated that the physical status and procedural time could be the principal factors accountable for death-risk. The primary aim was to verify the interaction between physical status and time to endoscopy on mortality; the secondary aim was to verify the interaction of the physical status and time to endoscopy on the length of stay (LOS).
METHODS: Consecutive patients admitted to 50 Italian hospitals were included. Clinical and endoscopic data were recorded. A multiple logistic regression analysis was performed and the interaction of adjusted clinical physical status and time to endoscopy on mortality was calculated.
RESULTS: Complete data were available for 3.190 patients. The time frames did not interfere with outcomes but influenced LOS. Conversely, the ASA score correlated with mortality, LOS, need for transfusions and rebleeding risk.
CONCLUSION: Endoscopy time should be tailored to the patient's physical. In our experience, ASA 1-2-3 patients can be safely submitted to endoscopy to reduce the LOS; on the contrary, keen attention should be paid to ASA4 patients, following the 'not too early-not too late' rule (12-24 h from admission).
ANS(autonomic nervous system) Watch has been developed as to detect pulse waves using a pressure detector. It is used to measured cardiovascular indices, including cardiac output, and vessel stiffness. ANSWatch is developed to apply to the prediction of traditional Chinese medicine (TCM) pulses, such as the wiry pulse. There are 28 types of pulses in TCM. Among them, the slippery pulse is the most commonly seen pulse in pregnant women. The present project plans to detect pregnant pulses using this portable ANSWatch connected to a laptop. One hundred pregnant women and 100 non-pregnant women will be recruited. After taking the indices of the subjects, a neural network is designed to provide the prediction for pregnancy constitution, pregnancy pulse and slippery pulse in pregnant women.
Patients will be randomized to Mifepristone-alone in a 1:1 manner prior to procedural abortions. A paracervical block of 20 cubic centimeters (cc) 1% lidocaine, with or without vasopressin, will be administered in accordance with standard practices.
It was aimed to investigate the relationship between SARS-CoV-2 infection severity and free and bioavailable vitamin D levels. This study was planned as a case-control study with patients hospitalized in the Haseki Training and Research Hospital Pediatric Infection Service. A total of 82 children, including at least 20 patients in each group were included in the study. The study group was divided into three groups according to COVID-19 WHO clinical progression Scale: unaffected (Group 1), mild (Group 2) and moderate (group 3). In order to investigate the relationship between disease severity and free and bioavailable vitamin D; 25OH vitamin d (μg/L), albumin (g/l) and VDBP levels (ELISA) were used. Vitamin D metabolites were calculated by using Bikle and Vermeulen methods (free Vitamin D BIKLE, free vitamin DVERMEULEN, bioavailable vitamin D). And these three vitamin D parameter levels were compared between groups.
Methods and systems of relieving stress for operators of vehicles are disclosed. In some embodiments, a set of inputs may be received from sensors after an operator begins operating a vehicle. The set of inputs may be processed to determine a stress level of the operator after vehicle operation begins. The stress level may be compared to a pre-determined stress level threshold. If the stress level is outside of the threshold and lower than the threshold, a first remediation measure may be implemented, and if the stress level is outside of the threshold and higher than the threshold, a different, second remediation measure may be implemented. Methods and systems of relieving stress for operators of vehicles are disclosed. A first set of sensor inputs may be received before an operator begins vehicle operation, and a second set of sensor inputs may be received after the operator begins vehicle operation. The first set of inputs may be processed to establish a baseline cognitive state, and the second set of inputs maybe processed to establish a current cognitive state. If the second set of inputs correlates to one or more physiological indicators of stress, and if a remediation measure will reduce a stress level of the operator based at least upon on a comparison of the current cognitive state to the baseline cognitive state, the remediation measure may be implemented.
Systems and methods for optimizing a risk assessment process according to various aspects of the present technology may include a server, a display, and a user device including a graphical user interface, a risk assessment engine, and a database. The graphical user interface may be configured to receive user data from a user, wherein the user data may include identifying information. The risk assessment engine may be configured to compute a risk score and generate a risk profile utilizing the identifying information and the risk score. The risk profile may indicate whether the user is likely to be harmed. The database may be configured to store the risk profile. The server may be communicatively linked to the database over a communication network, wherein the server may be provided with selective access to the risk profile. The display may be configured to present the risk profile.
Visual illusions and mental imagery are non-physical sensory experiences that involve cortical feedback processing in the primary visual cortex. Using laminar functional magnetic resonance imaging (fMRI) in two studies, we investigate if information about these internal experiences is visible in the activation patterns of different layers of primary visual cortex (V1). We find that imagery content is decodable mainly from deep layers of V1, whereas seemingly 'real' illusory content is decodable mainly from superficial layers. Furthermore, illusory content shares information with perceptual content, whilst imagery content does not generalise to illusory or perceptual information. Together, our results suggest that illusions and imagery, which differ immensely in their subjective experiences, also involve partially distinct early visual microcircuits. However, overlapping microcircuit recruitment might emerge based on the nuanced nature of subjective conscious experience.
Cognitive Training App CT-100-D-004-A uses implicit training with audiovisual stimuli to potentially redirect and modulate attention processes. This intervention is designed to help improve cognitive capabilities as well as redirect attentional biases to make participants less sensitive to distressing stimuli for multiple sclerosis with mobility limitations.
PURPOSE: Age-related macular degeneration (AMD) is a complex eye disorder affecting millions worldwide. This article uses deep learning techniques to investigate the relationship between AMD, genetics and optical coherence tomography (OCT) scans.
METHODS: The cohort consisted of 332 patients, of which 235 were diagnosed with AMD and 97 were controls with no signs of AMD. The genome-wide association studies summary statistics utilized to establish the polygenic risk score (PRS) in relation to AMD were derived from the GERA European study. A PRS estimation based on OCT volumes for both eyes was performed using a proprietary convolutional neural network (CNN) model supported by machine learning models. The method's performance was assessed using numerical evaluation metrics, and the Grad-CAM technique was used to evaluate the results by visualizing the features learned by the model.
RESULTS: The best results were obtained with the CNN and the Extra Tree regressor (MAE = 0.55, MSE = 0.49, RMSE = 0.70, R2 = 0.34). Extending the feature vector with additional information on AMD diagnosis, age and smoking history improved the results slightly, with mainly AMD diagnosis used by the model (MAE = 0.54, MSE = 0.44, RMSE = 0.66, R2 = 0.42). Grad-CAM heatmap evaluation showed that the model decisions rely on retinal morphology factors relevant to AMD diagnosis.
CONCLUSION: The developed method allows an efficient PRS estimation from OCT images. A new technique for analysing the association of OCT images with PRS of AMD, using a deep learning approach, may provide an opportunity to discover new associations between genotype-based AMD risk and retinal morphology.
The invention discloses a kind of preparation method of Lanqin oral liquid, its technical process includes：1. the kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine are placed in beaker, add suitable quantity of water to decoct 3-5 times, filtering；2. 3-5 decoction filtering liquid is merged, be placed in specified containers, be concentrated into finite concentration；3. the preparation of chitosan clarifier：Shitosan is weighed, is added water and glacial acetic acid, stirred, be heated to 70-90 DEG C, add water to certain volume, be incubated 40-60min, it is standby；4. the chitosan clarifier for preparing is added, in 70-90 DEG C of constant temperature water bath heating, is heated while stirring, stir 15-30min, taken out, in standing at 0-5 DEG C；5. taking supernatant adds appropriate purified water to be tuned into certain volume, and filling, sterilizing gets product.The preparation method do not destroy in the effective elements of the medicine, active ingredient can farthest be retained, the unstability compositions such as aldehydes matter, protein, colloid in herbal medicine can be efficiently removed, it is economical and practical, expense can be greatlyd save, with certain application prospect, it is adapted to industrialized production.
Myofascial pain syndrome (MPS) is the most common cause of musculoskeletal pain and its prevalence in the population is reported to be 21-30%. Rhomboid intercostal block (RIB) is an interfacial plane block described in 2016. It creates analgesia at T2-T9 levels in the hemithorax by applying local anesthetic to the fascia between the rhomboid muscle and the intercostal muscle. It has been used effectively in patients with chronic pain. The investigators planned a prospective observational study.From february to march 10 2021, a total of 30 patients who will apply to our clinic with MPS, will register in research. The investigators will perform ultrasound-guided RIB, and evaluate the clinical outcome Ultrasound guided RIB will applied with linear probe, in plane technique. Block needle was inserted to plane between the rhomboid muscle and intercostal muscles over the T5-6 ribs 2 cm to 3 cm medially from the medial border of the scapula. 13ml of bupivacaine 0.25% and 8mg dexamethasone mixture will inject into the fascial plane. Numerical Rating Scale (NRS) will recorded before and after the block at 30 minutes, day 1, 1-2-4-6 weeks.
Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study because there is no reliable marker in either preclinical models or clinical studies. Here, we performed a comprehensive electroencephalogram/electromyogram analysis of sleep in several mouse models of chronic pain: neuropathic (spared nerve injury and chronic constriction injury), inflammatory (Freund's complete adjuvant and carrageenan, plantar incision) and chemical pain (capsaicin). We find that peripheral axonal injury drives fragmentation of sleep by increasing brief arousals from non-rapid eye movement sleep (NREMS) without changing total sleep amount. In contrast to neuropathic pain, inflammatory or chemical pain did not increase brief arousals. NREMS fragmentation was reduced by the analgesics gabapentin and carbamazepine, and it resolved when pain sensitivity returned to normal in a transient neuropathic pain model (sciatic nerve crush). Genetic silencing of peripheral sensory neurons or ablation of CGRP+ neurons in the parabrachial nucleus prevented sleep fragmentation, whereas pharmacological blockade of skin sensory fibers was ineffective, indicating that the neural activity driving the arousals originates ectopically in primary nociceptor neurons and is relayed through the lateral parabrachial nucleus. These findings identify NREMS fragmentation by brief arousals as an effective proxy to measure spontaneous neuropathic pain in mice.
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as chronic local inflammation can largely impair bone healing. Here, we used magnesium silicate nanospheres (MSNs) to load microRNA-146a-5p (miR-146a) to fabricate a nanobiomaterial, MSN+miR-146a, which showed synergistic promoting effects on the osteogenic differentiation of human dental pulp stem cells (hDPSCs). In addition, miR-146a exhibited an anti-inflammatory effect on mouse bone marrow-derived macrophages (BMMs) under lipopolysaccharide (LPS) stimulation by inhibiting the NF-κB pathway via targeting tumor necrosis factor receptor-associated factor 6 (TRAF6), and MSNs could simultaneously promote M2 polarization of BMMs. MiR-146a was also found to inhibit osteoclast formation. Finally, the dual osteogenic-promoting and immunoregulatory effects of MSN+miR-146a were further validated in a stimulated infected mouse mandibular bone defect model via delivery by a photocuring hydrogel. Collectively, the MSN+miR-146a complex revealed good potential in treating inflammatory irregular oral-maxillofacial bone defects.
PROBLEM TO BE SOLVED: To obtain a perfume quality-improving agent capable of imparting or reinforcing a perfume having excellent freshness and excellent floral smell, when added to a cosmetic perfume composition, and also capable of emphasizing a top note and imparting a perfume having excellent freshness and excellent fruit smell, when added to a food perfume composition by using a specific compound. SOLUTION: This perfume quality-improving agent comprises 2R,-4S-trans-(+)- carveol of the formula. The compound of the formula is preferably obtained by a chemical synthesis method e.g. from advantageous points that the compound of the formula can be obtained in a high purity and in a large amount. Floral, fruity and citrus perfume compositions are preferable among cosmetic perfume compositions containing the compound of the formula, and citrus, tropical fruity, and floral perfume compositions are also preferable among food perfume compositions, because the above-described effects are remarkably expressed. The compound of the formula is preferably added in an amount of 0.001-5% based on the perfume composition.
OBJECTIVE: The objective of this retrospective study was to identify the uptake patterns and suggest a quantitative method to detect hyperostosis frontalis interna (HFI) on fluorine-18 sodium fluoride ([ 18 F]NaF) PET/computed tomography (CT).
METHODS: Between January 2019 and December 2021, patients who underwent [ 18 F]NaF PET/CT with a BMI of 30 and above, were included. Three nuclear medicine consultants reviewed the studies to determine the presence and identify the uptake patterns of HFI. Quantitative evaluation was performed on PET images using the total number of counts over the frontal bone and the ratio of counts between the frontal bone and iliac crest.
RESULTS: A total of 105 out of 249 cases were included in this study. Among these scans, there were 67 positive HFI in [ 18 F]NaF PET scans representing 64% of the studied population. As for the [ 18 F]NaF PET uptake pattern, there were 53 with uniformly diffused and 14 with heterogeneous uptake pattern. There were 17 out of 67 with positive HFI in [ 18 F]NaF PET scans but negative CT scans.
CONCLUSION: HFI is a common finding on [ 18 F]NaF PET in obese patients and is probably underdiagnosed. HFI may present with a heterogeneous and diffuse pattern of uptake on [ 18 F]NaF PET. The proposed quantitative analysis using the count ratios is in agreement with the visual evaluation of [ 18 F]NaF PET images regardless of the CT findings. Awareness of this condition and its scintigraphic patterns is warranted since it can have clinical significance and may mimic other pathologies including metastasis in cancer patients.
Oxalate, a uremic toxin that accumulates in dialysis patients, is associated with cardiovascular disease. As oxalate crystals can activate immune cells, we tested the hypothesis that plasma oxalate would be associated with cytokine concentrations and cardiovascular outcomes in dialysis patients. In a cohort of 104 US patients with kidney failure requiring dialysis (cohort 1), we measured 21 inflammatory markers. As IL-16 was the only cytokine to correlate with oxalate, we focused further investigations on IL-16. We searched for associations between concentrations of IL-16 and mortality and cardiovascular events in the 4D cohort (1255 patients, cohort 2) and assessed further associations of IL-16 with other uremic toxins in this cohort. IL-16 levels were positively correlated with pOx concentrations (ρ = 0.39 in cohort 1, r = 0.35 in cohort 2) and were elevated in dialysis patients when compared to healthy individuals. No significant association could be found between IL-16 levels and cardiovascular events or mortality in the 4D cohort. We conclude that the cytokine IL-16 correlates with plasma oxalate concentrations and is substantially increased in patients with kidney failure on dialysis. However, no association could be detected between IL-16 concentrations and cardiovascular disease in the 4D cohort.
Embodiments of the present disclosure provide methods and systems for facilitating manufacturing of the supplements unique to each user. The method performed by a server system includes receiving a request to manufacture a supplement through a health application available on a user device associated with a user. The method includes receiving a user survey response from the user. The method includes extracting user information from a plurality of sources, external databases and the user survey response. The method includes determining one or more micronutrients of the supplement and one or more parameters associated with each micronutrient based on the user information and artificial intelligence (AI) model. The one or more parameters include at least dosage value, serving form, and serving frequency of the supplement. Further, the method includes facilitating manufacturing of the supplement for the user in a timely manner based on monitoring a digital inventory of the user.
Objective.Sleep staging based on full polysomnography is the gold standard in the diagnosis of many sleep disorders. It is however costly, complex, and obtrusive due to the use of multiple electrodes. Automatic sleep staging based on single-channel electro-oculography (EOG) is a promising alternative, requiring fewer electrodes which could be self-applied below the hairline. EOG sleep staging algorithms are however yet to be validated in clinical populations with sleep disorders.Approach.We utilized the SOMNIA dataset, comprising 774 recordings from subjects with various sleep disorders, including insomnia, sleep-disordered breathing, hypersomnolence, circadian rhythm disorders, parasomnias, and movement disorders. The recordings were divided into train (574), validation (100), and test (100) groups. We trained a neural network that integrated transformers within a U-Net backbone. This design facilitated learning of arbitrary-distance temporal relationships within and between the EOG and hypnogram.Main results.For 5-class sleep staging, we achieved median accuracies of 85.0% and 85.2% and Cohen's kappas of 0.781 and 0.796 for left and right EOG, respectively. The performance using the right EOG was significantly better than using the left EOG, possibly because in the recommended AASM setup, this electrode is located closer to the scalp. The proposed model is robust to the presence of a variety of sleep disorders, displaying no significant difference in performance for subjects with a certain sleep disorder compared to those without.Significance.The results show that accurate sleep staging using single-channel EOG can be done reliably for subjects with a variety of sleep disorders.
INTRODUCTION: Falls are the leading cause of injury in older individuals, with intracranial hemorrhage (ICH) being a common complication. Anticoagulants, such as vitamin K antagonist and direct oral anticoagulants, are increasingly utilized, and clinicians may question the necessity of reversal in patients with minor ICH, especially in the setting of increased risk of adverse events. This study aimed to identify a population of patients with minor traumatic ICH at low risk for poor-neurologic status where anticoagulant reversal may not improve outcomes.
METHODS: This retrospective cohort study utilized data accessed from 35 trauma centers from 2018 to 2021. Patients included had a preinjury anticoagulant regimen, ICH due to blunt trauma, Glasgow Coma Scale score of 15, an Abbreviated Injury Scale (AIS) head score from 2 to 4, and an AIS of ≤1 for non-head regions within 24 h of hospital arrival. Patients were excluded if they required an emergent neurosurgical procedure or were on a preinjury purinergic-P2 receptor-12 protein (P2Y12) inhibitor. The primary outcome was the rate of in-hospital mortality or hospice.
RESULTS: There were 654 patients on preinjury anticoagulation who were included with a minor traumatic ICH without neurologic deficits. Overall, 263 patients were reversed and 391 were not reversed. Twelve (4.6%) patients with in-hospital mortality or hospice were reversed compared with 19 (4.91%) patients who were not reversed (p = 0.861). A composite of hospital complications occurred in 21 (8%) reversed patients and 34 (8.7%) not reversed patients (p = 0.748). The average intensive care unit length of stay was 1.4 ± 3.4 days in the reversed group and 1.1 ± 1.8 days in the not reversed group (p = 0.069).
CONCLUSION: This study found no difference in hospital outcomes between patients with minor traumatic ICH on oral anticoagulants who were neurologically intact that were reversed versus those who were not reversed. Further studies should continue to define the subset of traumatic ICH patients who may not require reversal of anticoagulation.