anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A cell therapeutic agent containing human mesenchymal stem cells, hyalronic acid, and tricalcium phosphate is provided to produce a large amount of homozygous stem cells. CONSTITUTION: A cell therapeutic agent for reconstructing bone contains human mesenchymal stem cells, hyaluronic acid, and tricalcium phosphate. The human mesenchymal stem cells are isolated from umbilical cord, umbilical cord blood, or placental tissue. The human mesenchymal stem cells are differentiated into bone cells within 1-7 days. The human mesenchymal stem cells are contained in 10^6 cells/defect size to 10^8 cells/defect size. The hyaluronic acid is crosslinked using 1,4-butanediol glycidyl ether.
Age is an independent risk factor for atrial fibrillation (AF), and curcumin can delay aging related disease through reducing oxidative stress and inflammation. However, its target in aging-related AF remains unclear. Transfer RNA-derived small RNA (tsRNA) is a novel short non-coding RNA (sncRNA), and exerts a potential regulatory function in aging. This study was to explore the therapeutic targets of curcumin in atrium of aged mice by PANDORA-seq. Aged mice (18 month) were treated with curcumin (100 mg/kg). Rapid transjugular atrial pacing was performed to observe AF inducibility. SA-β-gal staining, reactive oxygen species (ROS) detection and qRT-PCR were used to assess the degree of aging and oxidative stress/inflammation levels. PANDORA-seq was performed to reveal the differentially expressed sncRNAs in the atrium of mice. The results showed that curcumin reduced the susceptibility AF of aged mice by improving aging-related atrial fibrosis. Compared to young mice (5 month) group, aged mice yielded 473 significantly altered tsRNA sequences, while 947 tsRNA sequences were significantly altered after treated with curcumin. Enrichment analysis revealed that the target genes were mainly related to DNA damage and protein modification. Compared with the 5 month group, the expression levels of mature-mt_tRNA-Val-TAC_CCA_end, mature-mt_tRNA-Glu-TTC_CCA_end, and mature-tRNA-Asp-GTC_CCA_end were up-regulated in the 18 month group, while the expression of mature-mt_tRNA-Thr-TGT_5_end was down-regulated. This trend was reversed in the 18 month + curcumin group. Increased cellular ROS levels, inflammation expression and senescence in aged mice atrium were improved by the down-regulation of mature-mt_tRNA-Val-TAC_CCA_end. In conclusion, our findings identified mature-mt_tRNA-Val-TAC_CCA_end participated in the mechanism of aging-related atrial fibrosis, providing new intervention target of aging-related AF.
Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronaviruses in the future, including SARS-CoV-2 variants, might be compromised. Host-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging coronaviruses. Cathepsin L (CTSL) and calpain-1 (CAPN1) are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune response. Here, two peptidomimetic α-ketoamide compounds, 14a and 14b, were identified as potent dual target inhibitors against CTSL and CAPN1. The X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of α-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of CAPN1. Both showed potent and broad-spectrum anticoronaviral activities in vitro, and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern (VOCs) with EC50 values ranging from 0.80 to 161.7 nM in various cells. Preliminary mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral entrance. Moreover, 14a and 14b exhibited good oral pharmacokinetic properties in mice, rats and dogs, and favorable safety in mice. In addition, both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse model. And 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%. Further evaluation showed that 14a and 14b exhibited excellent anti-inflammatory effects in Raw 264.7 mouse macrophages and in mice with acute pneumonia. Taken together, these results suggested that 14a and 14b are promising drug candidates, providing novel insight into developing pan-coronavirus inhibitors with antiviral and anti-inflammatory properties.
Porcine deltacoronavirus (PDCoV) is a novel enteric coronavirus that can cause vomiting, watery diarrhea in pigs and the death of piglets. The open reading frame (ORF) 5 is one of the accessory genes in PDCoV genome and encodes an accessory protein NS6. To date, the function of NS6 is still unclear. In this study, the recombinant NS6 was successfully expressed in prokaryotic expression system and purified. To prepare monoclonal antibody (mAb), six-week-old female BALB/c mice were primed subcutaneously with purified NS6. A novel mouse mAb against NS6 was obtained and designated as 3D5. The isotype of 3D5 is IgG2b with kappa (κ) light chain. 3D5 can specifically recognizes the natural NS6 in swine testis (ST) cells infected with PDCoV and expressed NS6 in human embryonic kidney 293T (HEK 293T) cells transfected with mammalian vector. The minimal linear B cell epitope recognised by 3D5 on NS6 was 25VPELIDPLVK34 determined by peptide scanning and named EP-3D5. The sequence of EP-3D5 is completely conserved among PDCoV strains. Moreover, six to nine residues of EP-3D5 were identified to be conserved in non-PDCoV strains. These results provide valuable insights into the antigenic structure and function of NS6 in virus pathogenesis, and aid for the development of PDCoV epitope-associated diagnostics and vaccine design.
A preparation method for a traditional Chinese medicine used for the treatment of feet oedema type acute glomerulus nephritis, belongs to the technical field of traditional Chinese medicine preparation methods. Currently, carbenicillin is commonly used for the treatment of the kidney and yin deficient type acute glomerulonephritis, which may cause various types of allergic reactions. The technical scheme of the method is that: soaking the following 29 kinds of Chinese medicine herbs: poria cocos, polyporus, shuan-tsao root, polygonum aviculare, mole cricket, carp, crucian, cricket, Chinese pink herb, coffee senna, common alstonia, lophatherum gracile, mung bean, dandelion, stonecrop, shortstalk slimtop meadowrue root, fruticose breynia juvenile branchlet and leaf, smallleaf desmodium herb, franchet groundcherry calyx and fruit, Chinese twinleaf rhizome, radix rhapontici seu radix echinopsis, olive, drymoglossum subcordatum fee, justicia, gamboges, potentilla discolor, corn silk and licorice in water, and then decocting with slow fire. The decoction is the traditional Chinese medicine used for the treatment of feet oedema type acute glomerulus nephritis. The traditional Chinese medicine has the advantage of short treatment course and high cure rate and sovereign, minister, assistant and courier are just right. By using the traditional Chinese medicine, the adverse reaction, anaphylactic reaction and toxic response caused by using western medicine can be prevented.
A medicine image recognition method applied to an electronic device is provided. The method includes obtaining target images by inputting medicine images into a position detection network. Character feature matrices are generated according to the target images and a character recognition network. Image feature matrices are generated by inputting the target images into a category recognition network. Reference matrices are generated according to the image feature matrices and corresponding character feature matrices. Once a matrix to be tested is generated by processing an image to be tested, and a recognition result of the image to be tested is generated according to a similarity between the matrix to be tested and each of the reference matrices.
According to the definition of low carbon diet given by R. D. Feinman et al. (Nutrition, 2015), the daily carbohydrate intake of participants in this group was limited to 130g/ D, and the recommended diet was formulated according to the standard and combined with the local eating habits in Xi 'an, and dietary habit education was conducted. Participants could eat according to the recommended diet.
BACKGROUND: Target Product Profiles (TPPs) are instrumental to help optimise the design and development of therapeutics, vaccines, and diagnostics - these products, in order to achieve the intended impact, should be aligned with users' preferences and needs. However, patients are rarely involved as key stakeholders in building a TPP.
METHODOLOGY: Thirty-three cutaneous leishmaniasis (CL) patients from Brazil, Colombia, and Austria, infected with New-World Leishmania species, were recruited using a maximum variation approach along geographic, sociodemographic and clinical criteria. Semi-structured interviews were conducted in the respective patient's mother tongue. Transcripts, translated into English, were analysed using a framework approach. We matched disease experiences, preferences, and expectations of CL patients to a TPP developed by DNDi (Drug for Neglected Diseases initiative) for CL treatment.
PRINCIPAL FINDINGS: Patients' preferences regarding treatments ranged from specific efficacy and safety endpoints to direct and significant indirect costs. Respondents expressed views about trade-offs between efficacy and experienced discomfort/adverse events caused by treatment. Reasons for non-compliance, such as adverse events or geographical and availability barriers, were discussed. Considerations related to accessibility and affordability were relevant from the patients' perspective.
CONCLUSIONS/SIGNIFICANCE: NTDs affect disadvantaged populations, often with little access to health systems. Engaging patients in designing adapted therapies could significantly contribute to the suitability of an intervention to a specific context and to compliance, by tailoring the product to the end-users' needs. This exploratory study identified preferences in a broad international patient spectrum. It provides methodological guidance on how patients can be meaningfully involved as stakeholders in the construction of a TPP of therapeutics for NTDs. CL is used as an exemplar, but the approach can be adapted for other NTDs.
The sugar mannose has been used to maintain urinary tract health in the face of  E. coli  infections. An optimal dose is disclosed to be of one teaspoon (two grams) three times a day for one to two weeks or until symptoms subside. The maintenance dosage for prophalaxis is one-half teaspoon (1 gram) 1 to two times per day. Children's dosages are cut in half. For women who experience UTIs after sexual relations, one teaspoon is taken an hour prior to intimate relations and an additional one teaspoon immediately afterwards. It is further disclosed to use any of an extract of  Crataeva nurvala , white willow bark, and pollen extract in conjunction with the mannose to provide further effect.
The role of nutrition in chronic kidney disease (CKD) is well known. However, controversies, misconceptions, and gaps in the literature exist regarding the workforce required to provide nutrition care in CKD. This paper reviews the existing literature on this topic, focusing primarily on the United States. Topics covered in this review include the qualifications and services of the registered dietitian nutritionist (RDN), to which specific patients nutrition care should be provided in CKD and on dialysis, barriers to the utilization of nutrition services, the quantity of nutrition care needed to improve patient outcomes, and the risks of provider burnout. Controversies include whether more staffing is associated with better care and the best measures of staffing. The topics are supported with estimations for the economic impact and practicality of workforce decisions.
Background: Routine opt-out HIV testing is central to ending the HIV epidemic, as early case finding improves outcomes and reduces transmission. Despite strong evidence-based guideline recommendations, adoption of routine opt-out testing has been sub-optimal. Methods: A survey of providers and staff at an urban HIV and infectious disease clinic assessed awareness and knowledge of guidelines, screening practices, testing barriers, and possible interventions to improve testing. Responses were compared against actual testing data. Results: 86% of survey responders reported familiarity with guideline recommendations, and 37% reported routinely offering opt-out testing to all patients. A review of presumed HIV-negative patients over a two-year period showed that 7% of eligible patients had HIV screening ordered. Despite reported awareness of recommended routine HIV testing, testing was associated with perceived risk rather than offered uniformly, and potentially hampered by the COVID-19 pandemic and utilization of telemedicine visits. Provider education and electronic reminders, patient education, and rapid HIV test availability were proposed interventions to improve screening rates. Conclusions: Routine HIV testing was underutilized, with tests ordered based on perceived acquisition risk rather than offered uniformly.
A system for injecting controlled release medicinal implants has a syringe-like injector body with a lumen and plunger. A needle is attached to the injector body and receives therein an injectable implant with an internal hollow. The implant is retained in the needle by friction, which is overcome by the plunger upon dispensing. As the plunger moves from the retracted position to the deployed position, it forces a medicament previously loaded into the injector body into the implant hollow and then pushes the implant out of the needle into the creature into which the needle has been inserted. The implant may contain a filler to absorb flowable medicaments to aid in their retention within the implant. As in known implants, the medicament is released gradually depending upon the dissolution rate of the implant body which is formed from a biodegradable material. Because the medicament is loaded into the implant at the time of injection, issues concerning the reaction of the medicament with the implant material during preparation and storage are eliminated.
Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGFβ1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.
VS-6766 will be administered twice weekly in 4 week cycles in patients with multiple myeloma with a mutation in KRAS, NRAS or BRAF. In order to accommodate steroid use for patients with multiple myeloma, patients will be administered for 3 weeks followed by a week interruption.
The PI20 is a self-report questionnaire that assesses the presence of lifelong face recognition difficulties. The items on this scale ask respondents to assess their face recognition ability relative to the rest of the population, either explicitly or implicitly. Recent reports suggest that the PI20 scores of autistic participants exhibit little or no correlation with their performance on the Cambridge Face Memory Test-a key measure of face recognition ability. These reports are suggestive of a meta-cognitive deficit whereby autistic individuals are unable to infer whether their face recognition is impaired relative to the wider population. In the present study, however, we observed significant correlations between the PI20 scores of 77 autistic adults and their performance on two variants of the Cambridge Face Memory Test. These findings indicate that autistic individuals can infer whether their face recognition ability is impaired. Consistent with previous research, we observed a wide spread of face recognition abilities within our autistic sample. While some individuals approached ceiling levels of performance, others met the prevailing diagnostic criteria for developmental prosopagnosia. This variability showed little or no association with non-verbal intelligence, autism severity, or the presence of co-occurring alexithymia or ADHD.
Naproxen is rapidly and completely absorbed from the gastrointestinal tract with an in vivo bioavailability of 95%. The different dosage forms of naproxen are bioequivalent in terms of extent of absorption (AUC) and peak concentration (Cmax); however, the products do differ in their pattern of absorption. These differences between naproxen products are related to both the chemical form of naproxen used and its formulation. Even with the observed differences in pattern of absorption, the elimination half-life of naproxen is unchanged across products ranging from 12 to 17 hours. Steady-state levels of naproxen are reached in 4 to 5 days, and the degree of naproxen accumulation is consistent with this half-life. This suggests that the differences in pattern of release play only a negligible role in the attainment of steady-state plasma levels.
Pediatric participants with Ewing sarcoma (EWS) will receive eribulin mesylate administered as an IV infusion on Days 1 and 8 of each 21-day cycle at a dose of 1.4 mg/m\^2. Participants will continue study therapy until progression of disease (per RECIST 1.1), intolerable toxicity, or withdrawal of consent.
The invention discloses a cervical vertebra health care pillow, which comprises a cloth sleeve and a filling material. The filling material is a mixture of buckwheat hulls and tea. A ratio of the buckwheat bulls to the tea is 4-6:1. And the buckwheat bulls and the tea are soaked by a liquid medicament, and are dried out and then placed into the cloth sleeve. The liquid medicament comprises the following raw materials in part by weight: 30 to 50 parts of unprocessed radix aconiti, 5 to 15 parts of sweet osmanthus flower, 15 to 25 parts of chrysanthemum and 10 to 20 parts of szechuan lovage rhizome; and the raw materials are added with water to be boiled, and then the mixture of the buckwheat bulls and the tea is added to be soaked. The cervical vertebra health care pillow has simple proportioning, easy manufacturing, wide raw material source, lower cost and good health care effect, can be automatically adaptive to the profiles of the head and the neck to guarantee that the blood of the head circulates smoothly and tense muscles are completely relaxed, effectively prevents abnormal stress of the cervical vertebra, is suitable for various patients with cervical spondylosis, and has better economic benefit after being popularized.
A plurality of prediction methods of X-ray photography parameters and image quality is provided to solve the problem of unable to choose the lowest radiation dose and get a clear image of the conventional X-ray photography. The methods include a data collection step, a learning step, a photography parameter prediction step and an image quality prediction step. The data collection step collects the personal information, medical records, at least one physical parameter, at least one photography parameter, and an image quality of multiple X-ray subjects. The learning step analyzes the information collected in the data collection step, and establishes a photography parameter prediction model, a minimum acceptable photography parameter prediction model, and an image quality prediction model through data classification and curve fitting methods. The photography parameter prediction step inputs the at least one physical parameter to predict the at least one photography parameter. The image quality prediction step inputs the at least one physical parameter and the at least one photography parameter to predict the image quality.
Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers. In some embodiments, the disorder is selected from the group consisting of lung cancer, renal cancer, and an inflammatory disorder. In some embodiments, the lung cancer is selected from the group consisting of squamous cell carcinoma, and adenocarcinoma. In some embodiments, the inflammatory disorder is selected from the group consisting of rheumatoid arthritis, atherosclerosis, and restenosis. In some embodiments, the subject is mammalian. In some embodiments, the subject is human.
Subjects will receive treatment with oral prednisone 40 mg/day for 2 weeks, followed by fixed tapering over 6 weeks. Half of the subjects will be randomized to concomitant 6-MP 1-1.5 mg/kg/day and half will receive concomitant placebo treatment. During the entire course of the trial all subjects will receive maintenance treatment with 5-ASA in an oral dose of at least 2 gram per day. Subjects will be subjected to one colonoscopy at baseline and one sigmoidoscopy in week 52 in order to assess endoscopic disease activity.

Data will be collected using electronic case report forms (eCRF) with Castor EDC. Quality and data validation procedures will be applied to ensure the validity and accuracy of the clinical database. Monitoring of the study will be done according to the GCP guidelines and following a monitoring plan. The financier of the study, ZonMw Goed Gebruik Geneesmiddelen, has the right to perform an audit if seen necessary.