anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a medical and dental curable material cured at temp. in the vicinity of the room temp. or bodily temp., made long in a curing time and harmless to a living body, by using a calcium phosphate powder, which contains tetracalcium phasphate as an essential component, as a main material and using at least one substance selected from tannin, a tannin derivative and collagen as a curing retarder. CONSTITUTION:This medical and dental curable material contains a calcium phosphate powder, which contains at least tetracalcium phosphate (4CP) among 4CP and alpha-tricalcium phosphate (alpha-TCP) as an essential component, as a main material and, as a curing retarder, at least one kind of a substance selected from a group consising of tannin, a tannin derivative and collagen is used. The calcium phosphate powder pref. consists of 10-100wt.% of 4CP, 0-90wt.% of alpha-TCP and 0-30 wt.% of hydroxyapatite (HAp). When 4CP is below 10 wt.% of the calcium phosphate, the physical strength of a cured substance after kneading is extremely lowered. When HAp exceeds 30wt.% of the calcium phosphate powder, a curing time becomes short and sufficient kneading can not be performed.
FIELD: medicine. ^ SUBSTANCE: described is adhesive pharmaceutical composition which causes slighter skin irritation, preserves excellent bisopropol stability in medication and allows to introduce pharmacologically efficient amount of bisopropol into living organism continuously. Adhesive composition contains bottom layer, adhesive layer applied onto one surface of bottom layer. Adhesive layer contains bisopropol, polyisobytylene, adhesion-improving agent and organic liquid component compatible with polyisobytylene and adhesion-improving agent. Adhesive pharmaceutical composition has good skin adhesion with slighter irritation and is almost painlessly taken off or removed from skin surface almost without leaving adhesive substance. ^ EFFECT: bisopropol is hold in medication very stably, and pharmacologically efficient amount of bisopropol can be continuously introduced into li8ving organism through skin surface. ^ 14 cl, 1 dwg, 5 tbl, 14 ex
The present invention relates to a medicine for treating coronary disease, particularly to a Chinese parent medicine with Chinese herbal medicine used as raw material. The present invention also relates to a preparation method of the medicine. The medicine uses chuanxiong rhizome, cattail pollen, Trogopterus Dung and borneol as main raw materials. Four kinds of auxiliary medicine such as red sage root, giant knotweed rhizome, notoginseng and leech are added to the main raw materials as required. The materials are respectively dried, crushed or extracted by a solvent based on different characteristics of all kinds of Chinese herbal medicine. Powder preparation, capsule preparation and pill preparation are then formed proportionally. The present invention has the functions ofpromoting blood circulation and removing blood stasis, and promoting qi circulation and removing obstruction in the collateral channels. The present invention has obvious therapeutic effects on coronary disease and angina pectoris.
Participants in this group will participate in an evidence-based pelvic floor muscle training program that has been adapted to telehealth format. Training is begun 1 month before surgery and continued 2 months after surgery. Content is accessed in 10-minute sessions on a secure website - daily preoperatively and for the first 2 months post-operatively, then weekly until 6 months post-operatively. In addition to the pelvic floor muscle training, content will also include general perioperative care; wetness, odor and skin care management; and outcome measures.
A pharmaceutical compsn. consists of a central core contg 2 mg of eserine p-chlorophenoxyacetate (I) in Mg trisilicate, surrounded by a coating made of 1/3 Mg stearate and 2/3 Na dehydrocholate, this envelope contg. 100 mg glutamic acid and 200 mg papain. Used for treating inadequate gastric acid secretion. (I) is a known stimulant of acid secretion and does not have the side-effects associated with eserine itself. The other components all improve the digestive process and glutamic acid hydrochloride is a strong potentiator of (I). The Mg stearate-Na dehydrochalate coating is the one giving optimum release of (II) for a rapid effect.
INTRODUCTION: Meningiomas located in the posterior fossa and involving the sinodural angle at the junction of the transverse and sigmoid sinuses are uncommon and present unique challenges due to their complex anatomical location. Despite their distinctive features, they are frequently categorized with tentorial meningiomas in the literature.
MATERIALS AND METHODS: This retrospective study conducted at a tertiary care center involved 64 patients with sinodural meningiomas who underwent surgical treatment between 2010 and 2023. The analysis covered demographics, clinical presentation, radiological characteristics, surgical approaches, histopathological findings, and outcomes.
RESULTS: The cohort predominantly comprised females (83 %) with a mean age of 47.64 years. Headache (92.2 %) and gait disturbances (62.5 %) were the most common presenting symptoms. Preoperative imaging showed sinus involvement in 57.8 % of cases, predominating Sindou's type 1 and type 6. Gross total resection (Simpson grades 1-2) was achieved in 40.6 % of cases. Postoperative complications included pseudomeningocele (9.4 %), especially in patients with hydrocephalus.
CONCLUSION: Sinodural meningiomas represent a distinct subset of posterior fossa tumors, necessitating meticulous preoperative planning and intraoperative decision-making regarding sinus management. The study underscores the importance of individualized surgical strategies and highlights the role of radiosurgery in managing residual disease effectively.
BACKGROUND: Food access is associated with higher gastrointestinal (GI) cancer mortality; however, its association with frailty, which is a predictor of premature mortality among older adults with cancer, is less understood.
METHODS: The authors included 880 adults aged 60 years and older who were recently diagnosed with GI cancers and were undergoing self-reported geriatric assessment at their first prechemotherapy visit to the University of Alabama at Birmingham oncology clinic. Food access was measured using the 2019 US Department of Agriculture Economic Research Service designation low-income, low-access (LILA), classifying census tracts based on income and/or access to food stores at various distances. The primary outcome was frailty on the CARE (Cancer and Aging Resilience Evaluation) Frailty Index, a composite of the proportion of impaired geriatric assessment measures. The authors examined the LILA-frailty association with modified Poisson regression accounting for census-tract clustering.
RESULTS: The median patient age was 69 years, 58.1% were men, 22.5% were non-Hispanic Black, 29.2% had colorectal cancer, 28.0% had pancreatic cancer, 70.1% presented with stage III/IV disease, and 34.9% were frail. A higher proportion in LILA areas were non-Hispanic Black (44.1% vs. 10.8%; p < .001) and had less education (high school or less: 48.1% vs. 37.9%; p = .020). Adjusting for age, race and ethnicity, sex, cancer type and stage, and education, an LILA designation was associated with 58% greater odds of worsening frailty status (95% confidence interval, 1.18-2.12). An analysis of LILA subcategories revealed that associations were maintained across all LILA measures.
CONCLUSIONS: Poor food access was associated with a greater risk of frailty among newly diagnosed older adults with GI cancers before they received systemic treatment. Intervening on local food access, particularly in LILA areas, may be a target for improving rates of frailty and promoting health equity in this population.
BACKGROUND: Dysbacteriosis of intestinal tract may cause systemic inflammation, making distant anatomical locations more susceptible to illness. Recent research has demonstrated that the microbiome can affect both prostatitis and the inflammation of the prostate that is linked to prostate cancer. It is still unclear, though, whether this relationship indicates causation. We conducted a Mendelian randomization investigation on two samples to fully uncover gut microbiota's potential genetic causal role in prostatitis.
METHOD: Prostatitis (1859 prostatitis cases and 72,799 controls) was utilized as the outcome, while SNPs highly linked with 196 microbial taxa (18 340 people) were chosen as instrumental factors. Random effects, inverse variance weighting, weighted medians, and MR-Egger were used to analyze causal effects. The Cochran's Q test, funnel plot, leave-one-out analysis, and MR-Egger intercept test were all used in the sensitivity analysis.
RESULTS: A causal effect in lowering the incidence of prostatitis is anticipated for five gut microorganisms (Methanobacteria, Methanobacteriaceae, Erysipelatoclostridium, Parasutterella, and Slackia; P < 0.05). Four gut bacteria, including Faecalibacterium, LachnospiraceaeUCG004, Sutterella, and Gastranaerophilales, are predicted to play a causal role in increasing the risk of prostatitis (P < 0.05). There were no discernible estimates of pleiotropy or heterogeneity.
CONCLUSION: Our investigation established the genetic links between nine gut microorganisms and prostatitis, which may offer fresh perspectives and a theoretical framework for the future prevention and management of prostatitis.
PROBLEM TO BE SOLVED: To obtain a skin preparation for external use capable of only synergistically improving preventing and reducing effects on the skin roughening but also causing slight irritation to the skin by combining urea having softening effects on horny layers and reducing effects on the skin roughening with a specific compound. SOLUTION: This skin preparation for external use is obtained by combining urea with a low-molecular weight betaine. The low molecular weight betaine preferably includes quaternary ammonium salts of the formula (R<1> to R<3> are each a 1-6C alkyl, with the proviso that the total number of carbon atoms in the R<1> to R<3> is 8 or less). Trimethylglycine in which all the R<1> , R<2> and R<3> are methyls in the formula is most preferred. The urea is blended in an amount of preferably 0.5-7wt.%, more preferably 2-5wt.% based on the total weight of the skin preparation for external use. The low-molecular weight betaine is blended in an amount of preferably 0.01-30wt.%, more preferably 0.1-10wt.% based on the total weight of the skin preparation for external use.
Idiopathic atrioventricular block (iCAVB) is the most common reason for the need for a permanent pacemaker in the elderly population. The fibrotic process that occurs in the conduction system of the heart with aging is the main pathogenesis in the development of iCAVB. However, the processes that trigger the development of iCAVB in the elderly population have not been fully elucidated. In this study, we aimed to reveal the possible relationship between the endothelial glycocalyx (EG) layer and idiopathic complete atrioventricular block. A group of 68 consecutive patients who developed iCAVB and a group of 68 healthy subjects matched for age, sex, and cardiovascular risk factors were included in the study. The groups were compared for clinical, laboratory, and levels of Syndecan-1 (SDC1), an EG layer marker. In the study, SDC1 levels were found to be significantly higher in the iCAVB group compared to the control group (23.7 ± 7.5 vs 16.7 ± 5.2; p = 0.009). In multivariable regression analysis, SDC1 was determined as an independent potential predictor for iCAVB (OR: 1.200; 95% CI: 1.119-1.287; p < 0.001). In the receiver operating characteristic curve analysis, SDC1 predicted iCAVB with 74% sensitivity and 72% specificity at the best cut-off value of 18.5 ng/mL (area under the curve: 0.777; confidence interval: 0.698-0.856; p < 0.001). Disruption of the endothelial glycolic layer may be one of the main triggering factors for the process leading to iCAVB.
Participants will be asked to practice Yoga 3 times per week at a minimum, and daily at a maximum. Participants will receive training in different Yoga techniques including breathing exercises, postures and meditation. Participants will be asked to practice 1 hour Yoga sessions comprised of breathing exercises, postures and meditation.
A method for cryoablation of a tissue of a patient includes positioning a cryoablation gel composition adjacent to a tissue of the patient, and cryoablating the tissue and cryoablation gel composition with a cryoprobe. The cryoablation gel composition includes a polymer carrier and a thermal accelerant bound to the polymer carrier. The cryoablation gel composition may include a therapeutic drug. Cryoablating the tissue and the cryoablation gel composition can achieve a lethal isotherm at temperatures between −30 and −50° C. in a shorter duration of time than when compared to cryoablating the tissue without the cryoablation gel composition. Cryoablating the tissue and cryoablation gel composition can achieve a larger treatment volume in the tissue than when compared to cryoablating the tissue without the cryoablation gel composition. Furthermore, cryoablating the tissue and cryoablation gel plus drug composition can release the drug to treat the cryoablated cells with the therapeutic drug.
Biopolymeric implantable patches are popular scaffolds for myocardial regeneration applications. Besides being biocompatible, they can be tailored to have required properties and functionalities for this application. Recently, fibrillar biobased nanostructures prove to be valuable in the development of functional biomaterials for tissue regeneration applications. Here, periodate-oxidized nanofibrillated cellulose (OxNFC) is blended with lysozyme amyloid nanofibrils (LNFs) to prepare a self-crosslinkable patch for myocardial implantation. The OxNFC:LNFs patch shows superior wet mechanical properties (60 MPa for Young's modulus and 1.5 MPa for tensile stress at tensile strength), antioxidant activity (70% scavenging activity under 24 h), and bioresorbability ratio (80% under 91 days), when compared to the patches composed solely of NFC or OxNFC. These improvements are achieved while preserving the morphology, required thermal stability for sterilization, and biocompatibility toward rat cardiomyoblast cells. Additionally, both OxNFC and OxNFC:LNFs patches reveal the ability to act as efficient vehicles to deliver spermine modified acetalated dextran nanoparticles, loaded with small interfering RNA, with 80% of delivery after 5 days. This study highlights the value of simply blending OxNFC and LNFs, synergistically combining their key properties and functionalities, resulting in a biopolymeric patch that comprises valuable characteristics for myocardial regeneration applications.
PROBLEM TO BE SOLVED: To provide an agent for preventing or ameliorating hangover that is excellent in prevention or amelioration of hangover symptom.SOLUTION: The agent for preventing or ameliorating hangover of the present invention contains a lemon grass. The agent for preventing or ameliorating hangover preferably comprises at least one selected from amino acids, saccharide, artificial sweeteners and functional materials. The amino acids are preferably at least one selected from various amino acids and hydrates, salts, and derivatives thereof. The saccharide is preferably at least one selected from monosaccharide, disaccharide, and oligosaccharide of trisaccharide or higher. The functional material is preferably at least one selected from kudzu flower, turmeric and lactic acid bacteria. The agent for preventing or ameliorating hangover preferably also contains glucose and/or sodium chloride.SELECTED DRAWING: Figure 1
Cognitive Processing Therapy, a cognitive behavioral psychotherapy for PTSD patients. Based on a German manual adapted from Resick and Schnicke, 1993.
Participants first received Tamsulosin 0.4 mg or 0.8 mg taken daily in 2 week treatment periods, 4 treatment periods in 12 weeks. After a washout period of 1 week, the participants then received Placebo tablet taken daily in 2 week treatment periods, 4 treatment periods in 12 weeks.
Goal Management Training is a group metacognitive intervention to improve ability to complete complex task more effectively. 2-hour session are conducted in-person weekly over 10-weeks. A second weekly session includes Attention training which is conducted one-on-one with the therapist in the clinic. Participant completed 5-6 hours of homework between sessions.
Adult patients age ≥18 years who receive usual care after presenting to the ED of the control hospital emergency department before implementation of sepsis care reorganization (Code Sepsis implementation) at the intervention hospital. The primary analysis will focus on the subset of patients with sepsis.
Store IZERVAY in the refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Do not shake. Keep the vial in the original carton to protect from light.

Prior to use, the unopened glass vial of IZERVAY may be kept at room temperature, 20°C to 25°C (68°F to 77°F), for up to 24 hours. Ensure that the injection is given immediately after preparation of the dose.
Heavy metal compounds of mercaptokeratinates which are useful therapeutically are prepared by first forming the zinc compounds, then decomposing them with hydrogen sulphide, and finally treating the resulting mercaptokeratinic acids with compounds of heavy metals. The zinc compounds are obtained by hydrolyzing materials containing keratin with acid in excess until a jelly is produced, e.g. by the process described in Specification 370,295, reducing the product by addition of zinc, and neutralizing to precipitate the zinc compounds. As heavy metals are mentioned silver, gold, mercury, copper, lead, antimony, arsenic and bismuth, and their compounds include organo arsenic and antimony compounds.  Before adding arsenic, antimony or bismuth compounds, the combining capacity of the mercaptokeratinic acid may be estimated by titration with silver nitrate until no further reaction occurs with sodium nitroprusside.  In the case of the preparation of the gold compound, the keratinic acid solution may first be saturated with sulphurous acid.  According to the examples, (1) hair is treated with 20 per cent hydrochloric acid until converted into a gelatinous mass, zinc dust added in portions, and the zinc compound precipitated by neutralization with soda lye; (2) the keratinate prepared according to the process of Specification 370,295 is dissolved in hydrochloric acid, zinc added and the product neutralized; (3) hydrogen sulphide is passed into an p  aqueous suspension of the zinc compound of (1) or (2), the zinc sulphide filtered off, and the mercaptokeratinic acid isolated by evaporation in vacuo; (4) the acid of (3) is treated in aqueous solution with sodium aurichloride, silver nitrate, mercury acetate, copper acetate, lead acetate, sodium arsenite, potassium pyroantimonate, potassium antimonyl tartrate, bismuth ammonium citrate, gold trichloride (in the presence of sulphur dioxide), p-acetylaminophenylarsonic acid, p-acetylaminophenylarsine oxide, bismuth ammonium citrate, bismuth tartrate or bismuth nitrate, to give the corresponding heavy metal compound which either settles out or is precipitated by the addition of an organic agent, e.g. methyl or ethyl alcohol.  Specification 357,189 also is referred to.  The Specification as open to inspection under Sect. 91 describes also the preparation of any of the heavy metal compounds after first determining the combining capacity of the acid and contains a further example of the treatment of the above mercapto-keratinic acid with gold trichloride in the absence of sulphur dioxide. This subject-matter does not appear in the Specification as accepted.
PURPOSE: One of the most severe complications in surgery of parotid tumors is facial palsy. Imaging of the intra-parotid facial nerve is challenging due to small dimensions. Our aim was to assess, in patients with parotid tumors, the ability of high-resolution 3D double-echo steady-state sequence with water excitation (DE3D-WE) (1) to visualize the extracranial facial nerve and its tracts, (2) to evaluate their relationship to the parotid lesion and (3) to compare MRI and surgical findings.
METHODS: A retrospective study was conducted including all patients with parotid tumors, who underwent MRI from April 2022 to December 2023. Two radiologists independently reviewed DE3D-WE images, assessing quality of visualization of the facial nerve bilaterally and localizing the nerve's divisions in relation to the tumor. MRI data were compared with surgical findings.
RESULTS: Forty consecutive patients were included (M:F = 22:18; mean age 56.3 ± 17.4 years). DE3D-WE could excellently visualize the nerve main trunk and the temporofacial division in all cases. The cervicofacial branch was visible in 99% of cases and visibility was good. Distal divisions were displayed in 34% of cases with a higher visibility on the tumor side (p < 0.05). Interrater agreement was high (weighted kappa 0.94 ± 0.01 [95% CI 0.92-0.97]). Compared to surgery accuracy of MRI in localizing the nerve was 100% for the main trunk, 96% for the temporofacial and 89% for the cervicofacial branches.
CONCLUSIONS: Facial nerve MR-neurography represents a reliable tool. DE3D-WE can play an important role in surgical planning of patients with parotid tumors, reducing the risk of nerve injury.
Autism Spectrum Disorder (ASD) is a lifelong disorder that severely affects the ability to learn and function in a social environment. In typical function, higher level social, language and communication skills develop over the first few years of life and depend upon the critical building blocks of sensory-motor and attention abilities. Similarly in autism, higher level problems with social communication develop over the first two post-natal years and are preceded by subtle but abnormal visual attention and motor skills. Trainings to improve social interaction and communication are the most common of behavioral interventions in ASD. These therapies may improve the specific behaviors that are targets of the training, but rarely do they generalize to broader function or other clinical symptoms. The investigators propose that interventions aimed instead at the early deficits that support social and language skills would be more broadly effective. Because disruption of attention is one of the earliest and most persistent symptoms in autism, and because attention is highly subject to improvement with training, it is an important target for intervention.

This a novel intervention to train the speed and accuracy of attention orienting and eye movement. The training is designed to target attentional behaviors that have been shown to be impaired in autism, including attention orienting, disengagement and shifting, and a restricted attentional field. Because eye movement and attention are tightly linked, eye movement deficits in ASD parallel those found in spatial attention. Eye movements provide a marker for attention and the proposed training is designed to improve speed, accuracy and flexibility of eye movement and attention simultaneously. Training uses a series of entertaining video games to gradually shape behavior using visual and auditory feedback provided in real time. The investigators plan three levels of outcome measures for pre- and post-training to test the effectiveness of the intervention (direct tests of attention and eye movement; tests of improvement in attentional and visual monitoring and speed and accuracy of response in a simulated environment; tests of behavior in an actual social environment). The investigators will conduct clinical trials with control conditions (e.g., standard video games without training elements) with a small sample of ASD children aged 9-15. If this initial work is successful, the long term goal is to develop a readily available inexpensive eyetracker-based system for home use that is suitable for a broad age range of ASD children and adults.