anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A series of full thickness sutures done with Overstitch in the triangular stitch pattern as mentioned by Lopez-Nava\[29\] will be placed according to the APC markings. The suturing is initiated from the antrum distally and moved proximally towards the gastric fundus. A total of 6 to 8 plications are placed to reduce the gastric lumen. Five sham dressings would also be applied to patient's abdominal wall during the first week to minimize the bias in pain scoring.
PURPOSE: A process of preparing an apomorphine formulation for oral use by granulation of apomorphine, spraying a coating liquid at low temperature and spraying the coating liquid at high speed while floating the coating liquid at low temperature is provided. Whereby, the formulation is excellent in treatment of erectile dysfunction. CONSTITUTION: An excipient, binder and solvent are added to a mixed powder containing 1 to 10% by weight of apomorphine or acid salts thereof, 20 to 40% by weight of ascorbic acid, 10 to 20% by weight of domperidone to produce apomorphine granules. A coating liquid comprising 1 to 30% by weight of a coating base, 0.1 to 1.0% by weight of a plasticizer and a solvent is coated on 30 to 40% by weight of the granules at 30 to 40deg.C to produce first coated granules. A coating liquid comprising 1 to 30% by weight of a coating base and 0.1 to 1.0% by weight of a plasticizer is coated on 30 to 40% by weight of the first coated granules at 30 to 40deg.C to produce second coated granules. Thereafter, 40 to 50% by weight of apomorphine, 20 to 30% by weight of the first coated granules and 30% by weight of the second coated granules are mixed.
A 66-year-old male from Venezuela with history of high blood pressure and diverticulosis is being studied on an outpatient basis for abdominal pain and weight loss of several months of evolution. He presented to the emergency department due to worsening abdominal pain in the last 48 hours and fever. His abdomen was mildly tender to palpation in the left hypochondrium but did not exhibit signs of peritonitis. An abdominal x-ray was performed, revealing an oval, smooth-walled mass located in the left upper quadrant that contained a gas-fluid level. An outpatient abdominal CT scan performed two months earlier showed an intraabdominal, 14.8x10x16cm air cystic lesion, proposing giant colonic diverticulum as first diagnostic possibility. Given the findings of the abdominal x-ray, urgent abdominal CT was requested (image 3) with results suggestive of sigmoid-dependent giant diverticulum, complicated by probable superinfection and torsion of the sigma at its base. Considering the suspected diagnosis, the patient underwent diverticulectomy, demonstrating purulent content inside. Histopathology confirmed the diagnosis. Evolution after surgery was favourable and the patient was discharged on the sixth postoperative day.
1 - Cyclopentyl - 2 - methylamino - propane is obtained from cyclopentylacetone by (1) treatment with methylamine and a reducing agent, e.g. hydrogen, with a catalyst under heat and pressure or activated aluminium and water; (2) reduction and amination (e.g. treatment with ammonia and hydrogen with a catalyst under heat and pressure) to give 1-cyclopentyl-2-amino-propane, which is then methylated with formaldehyde, preferably in the presence of activated aluminium; (3) conversion into 1-cyclopentyl-2-amino-propane as in (2), treatment of this with benzaldehyde to give the Schiff's base and reaction of the latter with methyl iodide under pressure; (4) reduction to the carbinol (e.g. catalytic hydrogenation under heat and pressure), conversion into the corresponding bromide (e.g. by treatment with thionyl bromide in carbon tetrachloride) and reaction with methylamine, preferably under heat and pressure. The product reacts with acids to give salts and with moisture-saturated carbon dioxide to give a volatile carbonate and carbamate.  One salt may be converted into another by treatment with the appropriate acid or a salt and fractional crystallization of the product.  Examples are given of the various methods of preparing the amine and of the preparation of the hydrochloride, sulphate, oleate and carbonate. Other salts mentioned are the hydrobromide, carbamate, n-hexylsulphonate, malate, benzoate, glycollate, nicotinate, maleate, gluconate, phosphate and succinate.  Cyclopentylacetone is prepared as follows: A mixture of cyclopentanone, cyanoacetic acid, ammonium acetate and benzene is refluxed, and the resulting cyclopentylidene-acetonitrile freed from the accompanying cyclopentylidene-acetic acid by decarboxylation of the latter and distillation.  The nitrile is catalytically hydrogenated to give cyclopentylacetonitrile and the latter reacted with methyl magnesium iodide to yield cyclopentylacetone.
This is a stratified randomized trial. Firstly, the subjects were stratified according to disease severity (moderate, severe) and age stage (30-59 years, \> 60 years), and then the subjects were randomly assigned to the observation group and the control group within each stratum. The study center will screen cases strictly according to the diagnostic criteria, inclusion criteria and exclusion criteria. After confirmation of enrollment, random numbers will be obtained according to the application for random coding process until the total number of observation is completed. Blinded evaluation will be adopted in the trial, and the third party who does not know the grouping will evaluate the efficacy. Blind statistical analysis was used in the data summary stage, and the researchers, operators and statisticians were separated. In the observation group (acupuncture treatment + basic treatment), acupuncture will be applied at Dazhui (GV 14), Feishu (BL 13), Dingchuan (GV 14), Tiantu (GV 14), Danzhong (CV 17), Quchi (GV 20), Gongzhi (CV 4), Neiguan (PC 6), Yinlingquan (SP 9), Fenglong (ST 40), Qihai (CV 6). In the control group (sham acupuncture + basic treatment), sham acupuncture will be used. The acupoint selection is the same as the acupuncture treatment group, Before acupuncture, the fixed pad was pasted on the acupoints, 1.5-inch blunt needle will be used to Pierce the skin surface through the fixed pad of the sham appliance without puncturing the skin.

The mMRC and COVID-19 symptom assessment scale were used as the main evaluation indicators, and the Leicester cough questionnaire LCQ was used to record cough. VAS pain score visual analogue scale was used to evaluate the daily situation of sore throat, muscle soreness, and headache. Secondary outcomes included vital signs and oxygen saturation, chest CT score, and related blood biochemical indicators, including: Blood routine, coagulation routine, D-dimer, C-reactive protein, erythrocyte sedimentation rate, procalcitonin, cytokines (interleukin-6, interleukin-1, ferritin), myocardial enzymes, T lymphocyte subsets (CD4+, CD8+), liver function, renal function, blood gas analysis (severe patients), nucleic acid negative conversion rate, severe conversion rate, self-rating anxiety scale (SAS). Uniform training was provided to all study personnel. The training focused on the use of randomization system and case entry system, project implementation and standard operating procedures, so that each researcher could be familiar with the research process and specific implementation rules, so as to improve the intra-observer consistency and inter-observer consistency of researchers and ensure the reliability of clinical research conclusions. An independent efficacy evaluator was required. Efficacy raters and statistical analysts were blinded. Statistical analyses were performed by a third party, and statistical analysts were blinded during the trial. Statistical analysis will be calculated using SPSS22.0 statistical analysis software. P\<0.05 (i.e., =0.05) was considered to indicate statistical significance.
Resistance of acute myeloid leukemia (AML) cells to DNA damaging therapeutic agents is dependent on CHK1 protein levels. Here, the inventors demonstrate that in AML, CHK1 protein stability relies on the expression and activity of Ubiquitin Specific Protease 7 (USP7). CHK1 and USP7 levels are positively correlated in AML cell lines and primary patient specimens with high CHK1 protein levels. USP7 associates with CHK1, leading to its stabilization by deubiquitinylation, and this association is enhanced in response to cytarabine treatment. Pharmacological or RNA interference-mediated inhibition of USP7 significantly reduced AML proliferation  in vitro  and  in vivo , and increased AML cell death. It is important to note that USP7 inhibition synergized with cytarabine to kill AML cell lines. This is also the case in primary patient specimens with high CHK1 levels. Transcriptomic dataset analyses revealed that a USP7 gene signature is highly enriched in cells from AML patients at relapse, as well as in residual blasts from Patient Derived Xenograft (PDX) models treated with clinically relevant doses of cytarabine, strongly suggesting a relationship between USP7 expression and resistance to therapy. Finally, single cell analysis from AML patient at relapse  versus  diagnosis showed that a gene signature of the pre-existing subpopulation responsible for relapse is enriched in transcriptomes of patients with high USP7 level. Altogether, these data demonstrate that USP7 is a master regulator of CHK1 protein kinase in AML cells, and represents both a marker of resistance to chemotherapeutic treatments, as well as a potential therapeutic target to overcome treatment resistance.
Inhibition of eucaryotic pathogens and neoplasms and stimulation of lymphocytes and fibroblasts with lytic peptides such as cecropins and sarcotoxins. Eucaryotic cells are contacted with cecropin or sarcotoxin, or a synergistic combination of cecropins or sarcotoxin with lysozyme, in an amount effective to lyse or inhibit the cells. Target cells include eucaryotic microorganisms such as protozoa, e.g. T. cruzi and P. falciparum, mammalian lymphomas and leukemias, and cells infected with intracellular pathogens such as viruses, bacteria and protozoa. Also disclosed is a method for stimulating proliferation of lymphocytes and fibroblasts by contacting such cells with an effective amount of cecropin or sarcotoxin. The methods may be in vitro or in vivo.
Approximately 24 groups (6 per country; Finland, Norway, Spain, Italy) consisting participants aged 80+ recruited from: senior community centres, adult day care centres, nursing homes. Each focus group will comprise from 4 to 8 people. Attempts would be made to create gender-balanced groups.
Orthopaedic foot and ankle surgery is typically performed while the patient is under general or regional anesthesia. The Wide Awake Local Anesthesia No Tourniquet (WALANT) technique is a local anesthesia technique used since 1980s in Canada for hand surgery. WALANT uses a combination of a local anesthetic and vasoconstrictor to induce anesthesia and hemostasis in the area of the surgical procedure in order to allow surgeries to be done without the use of tourniquet. This practice eliminates the need for the tourniquet due to the hemostatic effect of the vasoconstrictor. The administration of the local anesthetic is done as close as possible to the surgical site, which allows the mobility of the joint to be maintained, while having complete anesthesia. The retention of mobility and the absence of a tourniquet improve patient comfort.

The main objective of this prospective study is to evaluate the perioperative pain level with WALANT anesthesia compared to general anesthesia during forefoot surgery.
Ischemia‒reperfusion (I/R) is a common complication in the clinical treatment of acute myocardial infarction (MI), in which cardiomyocytes play a pivotal role in the recovery of cardiac function after reperfusion injury. The expression of numerous circular ribonucleic acids (circRNAs) is disrupted in I/R-induced cardiac damage, but the potential role of circRNAs in I/R damage has not been fully elucidated. The purpose of the present study was to clarify the biological action and molecular mechanism of circRNA 002166 (also termed circCL2L13) in postmyocardial I/R. Oxygen-glucose deprivation/reoxygenation (OGD/R) in an in vivo model was performed to simulate I/R damage. real-time polymerase chain reaction analysis was also conducted to evaluate the relationships of the SOD1, SOD2, NRF2, HO1 and GPX4 indicators with oxidative stress injury. TUNEL immunofluorescence was used to evaluate the degree of cardiomyocyte apoptosis in the different treatment groups. The circBCL2L13 level was markedly upregulated in myocardial tissues from a mouse I/R model. Overexpression of circBCL2L13 markedly attenuated the expression of oxidative stress-related genes and apoptosis in OGD/R-induced cardiomyocytes. A mechanistic study revealed that circBCL2L13 functions as a ceRNA for miR-1246 and modulates paternally expressed gene 3 (PEG3). Eventually, circBCL2L13 was proven to regulate PEG3 by targeting miR-1246, thereby protecting against OGD/R-induced cardiomyocyte oxidative damage and apoptosis. In conclusion, our study confirmed that the circBCL2L13/miR-1246/PEG3 axis suppressed the progression of OGD/R injury in cardiomyocytes, which might lead to new therapeutic strategies for cardiac I/R injury.
The ASA score I-III Patients undergoing operation in OR under spinal anesthesia will be included in the study. Patients randomly assigned to VR group or Control Group. Patients will be carry out STAI-Trait Anxiety test preoperatively and second STAI test postoperatively. Spinal anesthesia will be performed after standard iv midazolam administration in both groups. After block reach adequate level for operation patient will wear the glasses and started to watch a documentary about birds and a sedative music by the headset in VR group and patient will take standard anesthesia care in Control group. The hemodynamic variables will be recorded during operation.
<P>PROBLEM TO BE SOLVED: To provide a composition for ophthalmic use which is suitably used for inhibiting the adsorption of a polymeric antimicrobial agent to a contact lens; and an agent and a method for inhibiting the adsorption of a polymeric antimicrobial agent to a contact lens.  <P>SOLUTION: The composition for ophthalmic use contains a monoterpene (especially, menthol, camphor, borneol or geraniol) and a polymeric antimicrobial agent (especially, a quaternary ammonium compound, a salt thereof, a biguanide compound or a salt thereof). An agent comprising the monoterpene for inhibiting adsorption of the polymeric antimicrobial agent to a contact lens, and a method of inhibiting adsorption are also provided. The composition for ophthalmic use is useful as an eye drop for ameliorating unpleasant symptoms caused by the polymeric antimicrobial agent (irritative feeling, hyperemia, dryness, etc.) not only in the case of wearing contact lenses but also in the case of not wearing them.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Solid dosage forms of potassium chlorides have produced stenotic and/or ulcerative lesions of the small bowel and deaths. These lesions are caused by a high local concentration of potassium ions in the region of the dissolving tablets, which injured the bowel. In addition, perhaps because wax-matrix preparations are not enteric-coated and release some of their potassium content in the stomach, there have been reports of upper gastrointestinal bleeding associated with these products. The frequency of gastrointestinal lesions with wax-matrix potassium chloride products is estimated at one per 100,000 patient-years. Experience with potassium citrate is limited, but a similar frequency of gastrointestinal lesions should be anticipated.

If there is severe vomiting, abdominal pain or gastrointestinal bleeding, potassium citrate should be discontinued immediately and the possibility of bowel perforation or obstruction investigated.
BACKGROUND: Solid organ transplant recipients are at an increased risk for anogenital Human Papillomavirus (HPV)-related disease, including anal high-grade squamous intraepithelial lesions (HSIL) and anal squamous cell cancer (ASCC). Guidelines for ASCC screening in transplant recipients are limited. Our aim was to understand current practice of ASCC screening in adult liver transplant (LT) candidates and recipients at transplant centers across the United States.
METHODS: We surveyed medical directors of 113 LT centers across the United States which had publicly available contact information. The survey evaluated center perceptions on cancer and HPV disease risk in transplant populations, ASCC screening, barriers and facilitators for ASCC screening and HPV vaccination practices.
RESULTS: We received 26/113 (23%) responses, of which 24 were complete and included in the analysis. Eleven of 24 (46%) centers reported screening for ASCC and 3/24 (12.5%) centers reported having formal guidelines. Centers who perform ASCC screening were more likely to perform transplants in people living with HIV and were more aware of the burden of HPV disease in transplant populations. All respondents believed that additional data on the impact of screening on ASCC incidence would support screening decisions. Increased access to specialists for screening/high-resolution anoscopy was also perceived as a facilitator. Only 7/24 (29%) centers regularly evaluated HPV vaccination status of their patients.
CONCLUSION: This national survey of LT centers reveals non-standardized ASCC screening practices, and identified data, educational and resource needs to improve prevention of ASCC in this population.
An asynchronous distributed generative adversarial network (AsynDGAN) can include a central computing system and at least two discriminator nodes. The central computing system can include a generator neural network, an aggregator, and a network interface. Each discriminator node can have its own corresponding training data set. In addition, different discriminator nodes can use different data modalities. The central computing system communicates with each of the at least two discriminator nodes via the network interface and aggregates data received from the at least two discriminator nodes, via the aggregator, to update a model for the generator neural network during training of the generator neural network. The central computing system can further include a data access system that supports third party access to synthetic data generated by the generator neural network.
LEARNING OBJECTIVES: After participating in this CME activity, the psychiatrist should be better able to:• Describe how to identify and address emotional eating in the primary care setting.
ABSTRACT: Emotional eating (i.e., eating in response to negative emotional states and stress) is a highly prevalent concern within primary care settings. It is associated with myriad health issues such as the experience of overweight or obesity, increased difficulty losing weight and sustaining weight loss, various eating disorders, diabetes, and heart disease. Given the effects of emotional eating on patient health goals regarding weight loss or management, it is imperative to incorporate interventions that address emotional underpinnings alongside traditional, behaviorally based weight-loss treatment. Ensuring that primary care providers, who represent pivotal frontline touch points for patients interested in weight-related treatment, can identify emotional eating is an important first step in supporting these patients' goals. The primary purpose of this paper is to provide background information and practical guidance for addressing emotional eating in the primary care setting. We summarize theorized biological and psychological mechanisms that underlie emotional eating, and review traditional (i.e., psychological) interventions, with special consideration for adapting available treatments for use in primary care contexts.
Described are peptides derived from or similar to the Erns protein of pestiviruses for type -specific diagnosis of infection, for eliciting antibiotic activity and for transport of substances into a cell. For these purposes among others an isolated, synthetic or recombinant protein module or functional equivalent thereof comprising an amino acid sequence that is at least 70% identical to an amino acid sequence of a peptide located from at about amino acid position 194 to 220 in a pestiviral Erns protein is provided. Figure 1 is a schematic representation of alignment of pestivirus Erns with RNase Rh, which indicates the modular organisation of Erns. Erns consists of an RNase domain (dotted) and a C-terminal membrane active domain (filled black). The C-terminal domain (residues 191-227) that shows resemblance to the L3 loop of cytotoxic RNases is also described. RNase active site domains are shown as chequered boxes. Potential glycosylation sites are shown as ellipses.
For patients in Group 1 with ≥30% TBSA, a baseline Echocardiogram (ECHO) will be obtained approximately one week from admission and monthly (+/- 1 week) or at an interval determined by cardiology during the acute inpatient stay. ECHO tests will be discontinued after 3 negative exams or when discontinued by cardiology, whichever comes first.
After completion of baseline assessment, participants were required to interact with the SAIF system for 4 months. They were followed up at 2-month (mid-way of intervention), 4-month (end of intervention), and 7-month (3 months post-intervention).
The invention discloses a big data medical pre-examination triage method and a system. Patient information is obtained. And obtaining the infectious disease condition through a pre-inspection model based on the patient information. If the infectious disease condition is 1, the user is informed to go to the infectious disease department or the point of diagnosis. The preview model includes a first preview structure, a second preview structure and a fused preview structure. And respectively inputting the patient information into the corresponding neural networks to extract features, inputting the features into the first pre-detection fusion neural network, and performing information fusion to obtain a first pre-detection vector. And before detection, according to the first pre-detection structure, the influence degree of each type of information on infection detection is obtained. And controlling the number of the random numbers and the maximum value to construct a second pre-detection structure. The connections are the loosest in the second pre-test configuration that minimizes the impact on infectious disease detection. And in order to detect the infectious disease more accurately, the first pre-detection vector and the second pre-detection vector are combined together to judge the infectious disease condition.
At the time of initial study visit, a estrogen vaginal ring (Estring) will be placed. Participants will retain this ring for 12 weeks.
The invention discloses a Chinese herbal preparation for treating hyperlipemia. Selected raw medicinal materials respectively comprise, by weight, 20 parts of fleece-flower root, 8 parts of safflower, 20 parts of dalbergia heartwood, 8 parts of Ligusticum wallichii, 12 parts of curcuma tuber, 5 parts of musk, 24 parts of Fructus Trichosanthis, 15 parts of Chinese garlic, 30 parts of Job's tears, 20 parts of red sage root, 30 parts of cassia seed and 20 parts of prunella vulgaris. The selected raw medicinal materials have complementary drug properties and effects. Mutual inhibition, mutual restraint and mutual-detoxication among medicines in compatibility are avoided. Mutual reinforcement and mutual-assistance among the medicines are remarkable. Thus, the Chinese herbal preparation has effects of clearing liver, reducing pressure, invigorating spleen, eliminating dampness and promoting blood circulation to remove meridian obstruction, and is an orally-taken preparation which is prepared from pure Chinese herbal medicines and is used for treating hyperlipemia.