anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The E-twenty-six variant 1 (ETV1)-dependent transcriptome plays an important role in atrial electrical and structural remodelling and the occurrence of atrial fibrillation (AF), but the underlying mechanism of ETV1 in AF is unclear. In this study, cardiomyocyte-specific ETV1 knockout (ETV1f/fMyHCCre/+, ETV1-CKO) mice were constructed to observe the susceptibility to AF and the underlying mechanism in AF associated with ETV1-CKO mice. AF susceptibility was examined by intraesophageal burst pacing, induction of AF was increased obviously in ETV1-CKO mice than WT mice. Electrophysiology experiments indicated shortened APD50 and APD90, increased incidence of DADs, decreased density of ICa,L in ETV1-CKO mice. There was no difference in VINACT,1/2 and VACT,1/2, but a significantly longer duration of the recovery time after inactivation in the ETV1-CKO mice. The recording of intracellular Ca2+ showed that there was significantly increased in the frequency of calcium spark, Ca2+ transient amplitude, and proportion of SCaEs in ETV1-CKO mice. Reduction of Cav1.2 rather than NCX1 and SERCA2a, increase RyR2, p-RyR2 and CaMKII was reflected in ETV1-CKO group. This study demonstrates that the increase in calcium spark and SCaEs corresponding to Ca2+ transient amplitude may trigger DAD in membrane potential in ETV1-CKO mice, thereby increasing the risk of AF.
BACKGROUND: Extended illness-death models (a specific class of multistate models) are a useful tool to analyse situations like hospital-acquired infections, ventilation-associated pneumonia, and transfers between hospitals. The main components of these models are hazard rates and transition probabilities. Calculation of different measures and their interpretation can be challenging due to their complexity.
METHODS: By assuming time-constant hazards, the complexity of these models becomes manageable and closed mathematical forms for transition probabilities can be derived. Using these forms, we created a tool in R to visualize transition probabilities via stacked probability plots.
RESULTS: In this article, we present this tool and give some insights into its theoretical background. Using published examples, we give guidelines on how this tool can be used. Our goal is to provide an instrument that helps obtain a deeper understanding of a complex multistate setting.
CONCLUSION: While multistate models (in particular extended illness-death models), can be highly complex, this tool can be used in studies to both understand assumptions, which have been made during planning and as a first step in analysing complex data structures. An online version of this tool can be found at https://eidm.imbi.uni-freiburg.de/ .
A multiple fluid model tool for training and/or refining of fluid models using disparate and/or aggregated machine data is presented. For example, a system includes a modeling component, a machine learning component, a three-dimensional design component and a data collection component. The modeling component generates a three-dimensional model of a mechanical device based on a library of stored data elements. The machine learning component predicts one or more characteristics of the mechanical device based on a machine learning process associated with the three-dimensional model. The three-dimensional design component provides a three-dimensional design environment associated with the three-dimensional model. The three-dimensional design environment renders physics modeling data of the mechanical device on the three-dimensional model based on the one or more characteristics of the mechanical device. The data collection component collects machine data via a communication network to update the three-dimensional model associated with the three-dimensional design environment.
PURPOSE: A dispensing article is provided to conveniently wash skin, metal wood, glass and plastics, and to rapidly dry the dispensing article while improving foaming performance. CONSTITUTION: A dispensing article comprises a first exterior layer; a second exterior layer; and a cell layer having at least one cell containing an active material wherein at least one layer is an aperture film. In addition, the cell layer is disposed between the two exterior layers. Typically, the dispensing article is useful for cleaning or treating surface including skin, metal, wood, glass and plastics. The aperture film opens at least of one exterior layer. Thereby, the dispensing article is conveniently washed with washing solution or treating solution. Moreover, the dispensing article is rapidly dried while improving foaming performance.
PROBLEM TO BE SOLVED: To provide an ophthalmic composition having improved effects on asthenopia caused by overuse of eyes such as video display terminal (VDT) operation or psychic tension, and further an ophthalmic composition having high respiratory activating actions on ophthalmic tissues. SOLUTION: This ophthalmic composition comprises xanthines (caffeine, theophylline, theobromine, proxyphylline, pentoxyphylline, etc.), and aspartic acid or its salt. Thereby, the asthenopia can be ameliorated. Furthermore, the composition comprises the xanthines (caffeine, theophylline, theobromine, proxyphylline, pentoxyphylline, etc.), and the aspartic acid or its salt. Thereby, ophthalmic tissue respiration can be activated.
Previous research on bone marrow transplants has conflicting results concerning the effects of maladjustment. The current research is conducted in consortium with DeVos Children's Hospital. Children receiving bone marrow transplants are assessed using the Child Behavior Check List (CBCL) and Cognitive based testing. Parents are assessed using the Parenting Stress Index (PSI). Children and parents are evaluated prior to transplant and then 50 days, 6 months, and one year post transplant. Descriptive statistics are currently being used to determine results.
This is a Phase I, open-label, single dose, dose-escalation trial in subjects with melanoma, breast cancer, or head and neck squamous cell cancer, liver, colorectal or pancreatic adenocarinoma. The intratumoral subjects will be stratified into 2 groups. Group A includes those who have been vaccinated with vaccinia virus. A history of vaccination and a scar at vaccination site is required. Group B subjects will include those who have not been vaccinated. It is expected that the toxicity profile will be quite different between those who have been vaccinated previously with vaccinia virus and therefore subjects will be stratified separately in this Phase I trial. All subjects who have refractory tumors will receive treatment at one of five dose levels in a single dose sequential dose-escalating design. Eligible subjects will receive 1 treatment of vvDD-CDSR. A dose can be divided between 1-3 lesions. The sum total of the maximal diameters of the lesion(s) to be injected must be \< 10cm.

Once the MTD and/or MFD has been defined in the vaccinated I.T. arm described above, additional subject may be enrolled at one dose level lower than the MTD/MFD and the I.V. infusion phase may begin. Patients enrolled in the IV infusion arm will receive a single administration of vvDD-CDSR at one of three dose levels in a sequential dose-escalating design.
BUD31, a splicing factor, is linked to various cancers. This study examines BUD31's expression, prognostic value, mutation profile, genomic instability, tumor immune environment, and role in clear cell renal cell carcinoma (ccRCC), focusing on cell cycle regulation via alternative splicing. BUD31 expression was analyzed using TCGA and GTEx databases across 33 cancers. Techniques included IHC staining, survival analysis, Cox regression, and nomogram construction. Mutation landscape, genomic instability, and tumor immune microenvironment were evaluated. Functional assays on ccRCC cell lines involved BUD31 knockdown, RNA sequencing, and alternative splicing analysis. BUD31 was upregulated in multiple tumors, including ccRCC. High BUD31 expression correlated with worse survival outcomes and was identified as an independent predictor of poor prognosis in ccRCC. High BUD31 expression also correlated with increased genomic instability and a less active immune microenvironment. BUD31 knockdown inhibited cell proliferation, migration, and invasion in vitro and reduced tumor growth in vivo. RNA sequencing identified 390 alternative splicing events regulated by BUD31, including 17 cell cycle-related genes. KEGG analysis highlighted pathways involved in cell cycle regulation, indicating BUD31's role in promoting cell cycle progression through alternative splicing. BUD31 is upregulated in various tumors and is associated with poor outcomes, increased genomic instability, and a suppressed immune microenvironment in ccRCC. BUD31 promotes cell cycle progression via alternative splicing, suggesting it as a prognostic biomarker and potential therapeutic target in ccRCC.
Monitored intravenous lidocaine infusion for patients with CP and pancreatic cancer is already current practice in the participating centers. Patients undergo treatment in the recovery unit of the anesthesiology department, for early detection of possible, although highly unlikely adverse events such as anaphylactic reactions, arrhythmias or hypotension. At the recovery unit continuous monitoring is possible and treatment of the above mentioned side effects can be easily provided. Continuous monitoring includes a 3-lead ECG, saturation, and blood pressure control every 15 minutes.
The second arm of the intervention includes walking through a guided forest trail suggested by NParks Board. The collection of samples and answering of the self-report questionnaire will follow the same sequence as the 1st arm of the 3-arm RCT.
PURPOSE:To obtain a skin remedy comprising a fruit wine as an active ingredient. CONSTITUTION:Leaves under snow are cleanly washed, soil is removed from the leaves, a fruit wine is poured to the leaves under snow dried not too excessively in such a way that the leaves under snow is immersed in a container. A cover is exactly placed on the container and allowed to stand and a green material is produced even from the leaves under snow to give a skin remedy. The remedy is effective as an antipruritic and for pain of hand and foot muscle and humid tetter. When one has a fever or toothache, application of the leaves under snow stops the pain and lowers the fever. The fruit wine in which the green material is produced from the leaves under snow is blended with about one-third as much dried mushroom obtained by slicing mushroom and drying in fine weather as the fruit wine to cause black harshness, which absorbs water and dries the skin, so the blend is effective for a rash of diaper, etc. A fruit wine containing UME (Japanese apricot) is effective for burn.
The present invention belongs to a pure traditional Chinese medicine preparation for treating vascular denmentia and a preparation method thereof. The preparation is prepared from the following raw materials according to the weight proportions: 500 to 800 g of chuanxiong rhizome, 500 to 800 g of epimedium herb, 300 to 450 g of ginkgo leaf and 300 to 450 g of angelica. The preparing method comprises: ethanol extraction: the epimedium herb and the ginkgo leaf; extraction of the medicine of volatile oil: the chuanxiong rhizome and the angelica; the extraction of medicine with a decocting method: the medicine dregs of the chuanxiong rhizome and the angelica after the volatile oil is extracted. The preparation has the effects for activating blood circulation to dissipate blood stasis, invigorating the kidney and benefiting intelligence, and is used for treating vascular dementia and people with blocked brain and nerves and weak kidney qi. The medicine and the preparation method thereof have the advantages of favorable effect, little medicine smell, high biological availability, advanced technology, accurate treating effect, safety and reliability. The preparation method has the advantages of high extraction efficiency, high purity and less medicine effect loss, and is suitable for modern industrial production.
The utility model relates to an eye protecting film using water jetting nonwoven cloth made from chitin fibre, which comprises eye holes, nose holes and a mouth hole at least. The utility model is characterized in that the eye protecting film comprises one chitin functional surface at least. Because chitin is used as primary materials of the eye protecting film, the utility model has an antibacterial and odour removal function, the sour and fishy odour of sweat excreted by a human body can be removed in time especially, and the utility model can eliminate the possibility of bacteria breeding and protects the cleanness and the health of skin. The utility model has the advantages of convenient use, portability and easy storage. A user can not feel uncomfortable when the utility model covers the face of the user. The utility model is without side effect.
Mitochondrial function is closely related to oocyte quality in female. Deficiency of multiple micronutrients is common in infertile women, and supplementation with multiple micronutrients has antioxidant effects to reduce the damage of oxidative stress to fertility, and helps to improve the outcomes of assisted reproductive treatment. RECO-18 is a functional food containing a variety of plant extracts and enzymatic soy phospholipids. In in vivo and in vitro senescent models, the investigators found RECO-18 to improve oocyte quality mainly by regulating the mitochondrial apoptosis pathway. The investigators also found RECO-18 significantly improved the fertility of mice, and the specific mechanism was related to reducing follicular atresia, promoting follicle development and improving oocyte quality. Based on the animal experiments, the investigators intend to conduct a clinical trial to explore whether RECO-18 plays a role in improving oocyte and embryo quality and pregnancy outcomes in infertile women undergoing in vitro fertilization-embryo transfer.
The efficacy of terbinafine tablets in the treatment of onychomycosis is illustrated by the response of subjects with toenail and/or fingernail infections who participated in three US/Canadian placebo-controlled clinical trials.

Results of the first toenail trial, as assessed at week 48 (12 weeks of treatment with 36 weeks follow-up after completion of therapy), demonstrated mycological cure, defined as simultaneous occurrence of negative KOH plus negative culture, in 70% of subjects. Fifty-nine percent (59%) of subjects experienced effective treatment (mycological cure plus 0% nail involvement or greater than 5mm of new unaffected nail growth); 38% of subjects demonstrated mycological cure plus clinical cure (0% nail involvement). 

In a second toenail trial of dermatophytic onychomycosis, in which nondermatophytes were also cultured, similar efficacy against the dermatophytes was demonstrated. The pathogenic role of the nondermatophytes cultured in the presence of dermatophytic onychomycosis has not been established. The clinical significance of this association is unknown.

Results of the fingernail trial, as assessed at week 24 (6 weeks of treatment with 18 weeks follow-up after completion of therapy), demonstrated mycological cure in 79% of subjects, effective treatment in 75% of the subjects, and mycological cure plus clinical cure in 59% of the subjects.

The mean time to overall success was approximately 10 months for the first toenail trial and 4 months for the fingernail trial. In the first toenail trial, for subjects evaluated at least 6 months after achieving clinical cure and at least 1 year after completing therapy with terbinafine tablets, the clinical relapse rate was approximately 15%.
PURPOSE: To provide a package which is inexpensive and can be unsealed so that instruments are not contaminated by bacteria to protect the instruments before use by dressing the axes of respective instruments in a nearly common plane when film members are stuck along the contact part and providing pockets for positioning the heads, the center parts, and the tails of respective instruments in corresponding instrument-containing spaces to respective pockets. CONSTITUTION: A space 15 for receiving articles is regulated to place thermoformed parts of pockets 11 in zigzag. It is preferable that the upper film 12 and the lower film 13 are completely reversely shaped. The outline 14 of a catheter in respective pockets 11 includes a head space 18, a tail space 19, and a center space 20. And these are shaped so as to support respective catheters. The pockets 11 have the same shape with each other. The plane defined by the contact faces 16, 17 is positioned at the center but when asymmetric instruments are contained, the pocket has a different shape therefrom.
Sotalol hydrochloride tablet (AF)'s most serious side effect, a different type of dangerous abnormal heartbeat, is discussed in " What is the most important information I should know about sotalol hydrochloride tablets (AF)?"  Dangerous abnormal heartbeats happen rarely. But they can be serious and, in rare instances, can even cause death. 

Sotalol hydrochloride tablet (AF)'s most common side effects are tiredness, slow rate, shortness of breath, and dizziness. Sotalol hydrochloride tablets (AF) can also cause other side effects. If you are concerned about these or any other side effects, ask your doctor.
In this triple arm, prospectively randomized multi centre phase IV study 200 patients per study arm will be investigated for 12 months.

Based on the results of the Symphony study the low dose tacrolimus study arm will be modified to further improve efficacy (prevention of BPAR, best possible renal function) and safety (adverse event profile regarding infections, cardiovascular risk factors, malignant tumours) of immunosuppression. For this, CNI will be reduced and in addition the rate of steroid free patients after 1 week will be maximized to achieve a long lasting improved post surgical cardiovascular risk profile (in particular concerning de novo induction of diabetes mellitus and other adverse events caused by steroids). Safety should be increased without loss of efficacy of immunosuppression (measured in rejection rate and allograft loss rate) as compared to an immune suppressive therapy comprising steroids. Therefore, following the successful study arm of the Symphony study, immunosuppression in the first of the three study arms comprises a steroid in combination with Advagraf and CellCept in addition to a two dose induction therapy with Simulect (group A). The regimen of the second study arm is similar but discontinues steroids on day seven after transplantation (group B). Therapy of group three is similar to group B but Simulect is replaced by T-cell depleting polyclonal antibodies (Thymoglobulin) (group C).
PURPOSE: Amblyopic and strabismus subjects experience inter-ocular suppression, impaired stereoacuity, and increased fixation instability. The purpose of the study was to investigate factors affecting suppression and stereoacuity and examine their relationship to fixation eye movement (FEM) abnormalities.
METHODS: We recruited 14 controls and 46 amblyopic subjects (anisometropic = 18, strabismic = 14, and mixed = 14) and 11 subjects with strabismus without amblyopia. We utilized the dichoptic motion coherence test to quantify suppression, and stereoacuity was assessed using the Titmus Fly test. We recorded FEMs using high-resolution video-oculography and classified subjects that did not have nystagmus (n = 27) versus those with nystagmus (n = 32; fusion maldevelopment nystagmus [FMN], n = 10) and nystagmus that did not meet the criteria of FMN (n = 20). We also recorded FEMs under dichoptic viewing (DcV) at varied fellow eye (FE) contrasts and computed the amplitude and velocity of the fast and slow FEMs and vergence instability.
RESULTS: Inter-ocular suppression and stereoacuity deficits were closely correlated with an amblyopic eye (AE), visual acuity, and strabismus angle. Subjects with nystagmus displayed more pronounced stereoacuity deficits than those without nystagmus. Strabismic subjects with and without amblyopia, who demonstrated a fixation switch at 100% FE contrast, had lower inter-ocular suppression than subjects lacking a fixation switch under DcV. Amplitude of fast FEMs and velocity of slow FEMs, and vergence instability were increased as the FE contrast was lowered in both amblyopic and strabismic subjects.
CONCLUSIONS: The current study highlights the intricate relationships between AE visual acuity, eye deviation, and FEM abnormalities on suppression and stereoacuity deficits and underscores the need to evaluate FEM abnormalities while assessing dichoptic treatment outcomes.
BACKGROUND: The IPAA has been successful in restoring intestinal continuity and preserving continence in the majority of patients requiring a proctocolectomy. However, a subset of individuals experience significant complications that might result in pouch failure. The conversion of the J-pouch to a continent ileostomy pouch represents a significant surgical procedure. In this article, we discuss the indications and contraindications, present the technical principles applied for the conversion, and describe the outcomes of such conversion in the literature.
OBJECTIVE: The main objective during the conversion of the J-pouch to a continent ileostomy is the creation of a sufficiently sized reservoir with a high-quality valve mechanism while preserving as much small bowel as possible.
CONCLUSIONS: The conversion of the J-pouch to a continent ileostomy represents a significant surgical procedure. When performed in centers of expertise, it can be a good option for patients who otherwise will require an end ileostomy. Indications for conversion include most cases of J-pouch failure, with a few important exceptions. See video from symposium .
After an initial assessment, the waitlist comparison group did not receive any treatment for 12 weeks. They were then re-assessed at 12-weeks post-baseline and this data was used to compare this group to the experimental group to determine the effectiveness of the CBT-Meno treatment. After this re-assessment participants in the waitlist condition were offered the same CBT-Meno treatment as the experimental group: 12 weekly sessions (2 hours long) of cognitive-behavioural therapy for menopausal symptoms.
Adipose is aspirated from the subcutaneous tissue of the buttock or abdomen. Aspiration site is injected with 10ml 1% lidocaine with epinephrine. A small poke incision is made with an 11-blade scalpel. Then 120ml of Klein solution is injected into the adipose tissue. Solution sits for 15 minutes to allow for adequate anesthesia. Aspiration cannula is inserted and moved in a back and forth motion for 2 minutes to allow for adipose aspiration. 30ml fat will be aspirated. Aspiration site is cleaned and bandaged. The aspirated fat is processed using the Lipogems system. 30ml of adipose is transferred to the device, saline is run through the device to remove oils and then approximately 5-7ml of adipose tissue is removed and ready for injection. The Microfragmented adipose tissue are then injected in identical fashion to the PRP above.
Either 50mg/13mg LD/CD per hour or 68mg/17mg LD/CD per hour flow rate based upon Subject's standard levodopa (LD) dose. Subjects will routinely wear each container for approximately 5 hours (3 containers per day).
Control of the sexual cycle of water frogs (Rana sp.) for leaf frogs (Hyla sp.) comprises treating the frogs of both sexes (a) with follicle stimulating hormone (FSM) and luteinising hormone (LH) as one or two separate injections, then (b) when the animals characteristic mating colour has appeared, with a further dose of FSH and LH, plus chorionic gonadotropin (CG) in 1, 2 or 3 injections. Also new are compsns. for this process. USE/ADVANTAGE - Treatment is used in artificial breeding programmes and overcomes the limitation that these frogs normally mate only once after capture, i.e. it allows 4 matings per yr. without any adverse effects on health. The legs of these frogs are a luxury food and the offspring of treated parents contain no hormone residues.