anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a malignant tumor therapeutic vaccine and a composition thereof. The malignant tumor therapeutic vaccine is a tumor cell line obtained by culture of a human tumor tissue's cancer cells. A TGF-beta2 antisense plasmid is transfected into the tumor cell line, and the tumor cell line is subjected to inactivation, thus obtaining the malignant tumor therapeutic vaccine. The invention also relates to a malignant tumor therapeutic vaccine composition, which includes the malignant tumor therapeutic vaccine and an immunopotentiator. The malignant tumor therapeutic vaccine provided by the invention can be used for treating the tumor cell sourced patients, and has the advantages of strong immune antigen specificity, repeated preparation and use and low price, and also can be prepared into a vaccine preparation for treatment of other patients suffering a same cancer. Animal experiments confirm that the malignant tumor therapeutic vaccine has a good treatment effect.
Xenohormesis proposes that phytochemicals produced to combat stressors in the host plant exert biochemical effects in animal cells lacking cognate receptors. Xenohormetic phytochemicals such as flavonoids and phytoalexins modulate a range of human cell signaling mechanisms but functional correlations with human pathophysiology are lacking. Here, potent inhibitory effects of grapefruit-derived Naringenin (Nar) and soybean-derived Glyceollins (Gly) in human microphysiological models of bulk tissue vasculogenesis and tumor angiogenesis are reported. Despite this interference of vascular morphogenesis, Nar and Gly are not cytotoxic to endothelial cells and do not prevent cell cycle entry. The anti-vasculogenic effects of Glyceollin are significantly more potent in sex-matched female (XX) models. Nar and Gly do not decrease viability or expression of proangiogenic genes in triple negative breast cancer (TNBC) cell spheroids, suggesting that inhibition of sprouting angiogenesis by Nar and Gly in a MPS model of the (TNBC) microenvironment are mediated via direct effects in endothelial cells. The study supports further research of Naringenin and Glyceollin as health-promoting agents with special attention to mechanisms of action in vascular endothelial cells and the role of biological sex, which can improve the understanding of dietary nutrition and the pharmacology of phytochemical preparations.
Mind-body interventions are increasingly being examined for their potential to improve cognitive function, enhance emotion regulation, reduce stress and related inflammatory markers, and alter the neural circuitry supporting cognitive and emotional functioning. The primary goal of this study is to examine changes in attentional control resulting from engaging in mind-body interventions with additional booster sessions over the course of a year. Within this goal, the behavioral and neural mechanisms of change in attentional control will be investigated and the transfer of benefits to performance on measures of everyday cognition and emotion regulation will be assessed. Our main hypothesis is that eight weeks of mindfulness training will increase attentional control performance in the elderly, partially through mindfulness-induced reductions in mind-wandering and changes in the functional architecture of the brain. Up to 200 older adults (ages 65-85) will be enrolled for the study. Of these, 151 older adults meeting eligibility criteria will be randomized to either an eight-week MBSR (mindfulness based stress reduction) program or a lifestyle education group. Participants will attend weekly mindfulness training or lifestyle education sessions and will be asked to complete homework assignments administered via a mobile/web-based application designed by the laboratory. All participants will also be invited to participate in four booster sessions over the course of 12 months following the intervention with continued access to the mobile application content. Behavioral metrics of cognitive function and inflammatory markers will be collected before and after the eight-week intervention as well as at 6-months and 12-month follow-up assessments. Neural metrics of cognitive functioning will be collected before and after the eight-week intervention as well as at 12-month follow-up assessments.
<P>PROBLEM TO BE SOLVED: To solve the problem that although it is hardly necessary to consider the contamination of powder cosmetics with microorganisms in an unused state, the contamination by mixing with water and from the hands, a cosmetic powder puff, the air and the like has to be considered after starting the use and due to this, an aseptic is incorporated in consideration of antibacterial properties even in these powder cosmetics but sufficient antibacterial activity cannot be obtained with these powder cosmetics.  <P>SOLUTION: A powder cosmetic contains sodium chloride as an essential component. The amount of the sodium chloride incorporated is not particularly limited and normally the sodium chloride may be incorporated in an amount of 0.001-1 wt.%. A preferred amount is 0.01-0.5 wt.%. With amounts of 0.001 wt.% or less the effect is sometimes not sufficient and with amounts of 1 wt.% or more there is no increase in the effect, and such amounts are uneconomical.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Weight abnormalities (underweight, overweight, and obesity) can cause life-threatening ailments. This study investigates disparities in the prevalence of underweight, overweight, and obesity between northern and southern Nigeria and their associated factors. Using the 2018 Nigeria Demographic and Health Survey (NDHS), the study analysed a sample of 12,333 women with complete records of body mass index. The study found that southern women had lower odds of being underweight than women in the north, but the reverse was the case for overweight and obesity. The prevalence of underweight was 11.6%, and it varies from 6.9% in the southern state of Enugu to 31.6% in the northern state of Jigawa. The national prevalence of overweight was 17.9%, ranging from 6.7% in Jigawa State of the northern region to 39.9% in Lagos State of the south. Similarly, the prevalence of obesity in the north was 6.1% compared to 14.4% in the south, with Anambra State of the southern region recording the highest figure of 35.5% compared to 2.1% in the Yobe State of the northern region. In all, the rate of abnormal weight was significantly higher in the south than in the north. However, the type of weight abnormality varies between the two regions. Religion, education, use of contraceptives, and wealth were associated with the three forms of abnormal weights. However, while religion was significantly associated with obesity in the north, the association was not significant in the south. This study found that wealth and education have dissimilar influences on overnutrition. While the odds of being overweight and obese increase with wealth, being educated up to a secondary level significantly reduces the odds in Nigeria and across the two regions.
INTRODUCTION: Recent studies have reported the efficacy of the cryoballoon (CB)-guided left atrial roof block line (LARB) creation in patients with persistent atrial fibrillation (AF). However, it can be technically challenging to attach the balloon to the left atrial (LA) roof due to its anatomical variations. We designed a new procedure called the "Raise-up Technique," which may facilitate the firm adhesion of the CB to the LA roof during freezing. This study aimed to evaluate the efficacy of the Raise-up technique in LARB creation.
METHODS AND RESULTS: In total, 100 consecutive patients with persistent AF who underwent CB-LARB creation were enrolled. Fifty-seven patients underwent LARB creation using the Raise-up technique (Raise-up group), and the remaining 43 did not use it (control group). The Raise-up technique was performed as follows: An Achieve catheter was inserted as deeply as possible into the upper branch of the right superior pulmonary vein to anchor the CB. The balloon was placed below the targeted site on the LA roof and frozen. When the temperature of the CB reached approximately -10°C and the CB was easier to attach to the LA tissue, the CB was raised and pressed against the LA roof immediately by sheath advancement. Then the balloon could be in firm contact with the target site on the roof. If necessary, additional sheath advancement after sufficient freezing (-20°C to -30°C) was allowed the CB to have more firm and broad contact with the target site. LARB creation without touch-up ablation was achieved in 54 of 57 patients (94.7%) in the Raise-up group and 33 of 43 patients (76.7%) in the control group (p < .05). The lesion size of the LARB in the Raise-up group was significantly larger than that in the control group (15.2 cm2 vs. 12.8 cm2, p < .05). Moreover, the width of the LARB lesion in the Raise-up group was wider than that in the control group (32.0 mm vs. 26.6 mm, p < .05).
CONCLUSION: The Raise-up technique enabled the creation of seamless and thick LARB lesions with a single stroke. In addition, the CB-LARB lesions created using the Raise-up technique tended to be large, resulting in extensive debulking of the LA posterior wall arrhythmia substrates. In CB ablation for persistent AF, the Raise-up technique can be considered one of the key strategies for LARB creation.
The invention relates to tartaric acid mikamycin for injection and preparations and preparation method of the tartaric acid mikamycin. The tartaric acid mikamycin is soluble mikamycin tartrate separated from reactant precipitation of the mikamycin and tartaric acid in C1-C4 low alcohols. The molar ratio of the mikamycin and the tartaric acid is 1:1.6-2.0. The tartaric acid mikamycin is sterilized at 140 DEG C for 3h, and is aseptically packaged with 1.5g per bottle, and powder-injection is obtained. The preparation method of the tartaric acid mikamycin for the injection is further provided. The tartaric acid mikamycin for the injection is good in water solubility and is dissolved in sterile normal saline in the clinical use process, solutions are low in viscosity, easy to absorb and easy to inject, clinical use is simple and convenient, and irritation on animals is small.
Complete questionnaires at baseline (administered electronically or by mail). Follow-up measures will be administered immediately following their clinic visit and at 6-months after the clinic visit electronically and by mail. A PREVENT action plan (behavior change prescription, community resources, and education) will be provided to the patient via email after the completion of the follow-up measurement.
This article presents our experience of performing a new laparoscopic method of radical orchiectomy. At the JSC "European Medical Center" in the period from 2022 to 2024 we performed laparoscopic radical orchiectomies in three patients with testicular cancer. All patients were examined on an outpatient basis, ultrasound and MRI of the scrotum, PET-CT scan were performed, and laboratory tests were carried out. Malignant testicular lesion was confirmed in all patients. All operations were performed in full volume, without complications during the operation and in the postoperative period. The duration of the laparoscopic surgery was comparable to the standard open technique. In the postoperative period the pain intensity in the area of surgery, the recovery period and the presence of complications were evaluated. CONCLUSION: Radical orchiectomy with laparoscopic assistance is a minimally invasive method of surgical treatment of testicular tumors, which allows to perform the removal of the testis and elements of the spermatic cord as radically and safely as possible, and also has pronounced advantages in the form of reduction of postoperative pain syndrome in the area of surgery (no more than 2 points on VAS), reduction of the recovery period and the risk of possible postoperative complications.
Patients will undergo a standard total minimally invasive transthoracic Ivor Lewis esophagectomy with preemptive ENP. After completion of the esophago-gastric anastomosis, an Eso-SPONGE® system will be inserted via an intraoperative gastroscopy. ENP will be carried out upon completion of the esophago-gastrostomy, but no later than 12 hours after the surgical intervention. Postoperatively, secretions are then continuously evacuated using a suction pump generating a negative pressure between 75 and 100 mmHg. ENP will remain for 4 days and will be monitored with clinical parameters.
Introduction: Instrumentation kinematic is one of the many aspects of shaping files that underwent heavy development through the last decade. The impact of the type of motion used to drive shaping instruments was heavily studied but mostly in-vitro. More randomized clinical trials are needed to achieve a reliable body of data concerning the issue.

Aim: This study aimed to evaluate the effect of varying shaping files' kinematics on bacterial reduction, post-operative pain and the incidence of flare-ups. Methods: Necrotic, asymptomatic, single-rooted mandibular premolars with single canals were used in the study, where 46 patients were randomly allocated to two groups. In the first group, WaveOne Gold was used for mechanical preparation while One Shape was used in the second group. Samples were taken preoperatively (S1) and after chemomechanical preparation (S2). Bacterial reduction was evaluated and compared between both groups via culturing technique and quantitative analysis by real-time polymerase chain reaction (qPCR). Post-operative pain and the incidence of flare-ups were also evaluated using the visual analog scale (VAS) method.
Creatine monohydrate. Guinama brand with CE marking. Code 89823.
The Physician To Patient (P2P) network system, a private & secure infrastructure for independently practicing physicians and patients for real-time electronic communication & transfer of patient health information is disclosed by the invention. The invention also discloses an efficient and natural method for creation of Electronic Medical Records by physicians in their own handwriting. The P2P network system utilizes a plurality of devices and components defined by the invention, and custom programming to integrate all equipment, devices and components of the network system. The invention also discloses a highly targeted method of advertising, the One2One Advertising, for healthcare product manufacturers to reach physicians and patients. A number of healthcare related business processes, currently executed manually are performed automatically by P2P network system software. The invention will improve the quality of services to patients, and reduce the overhead cost of the medical offices, and the healthcare industry.
The present invention discloses wine for reducing blood fat and blood pressure, which relates to health wine. The present invention aims to solve the problem that the existing health wine has no health care action on pathological symptoms, such as hyperlipoidemia, hypertension, etc. The present invention is prepared from (by weight percentage) 60 to 99% of pure grain spirit and 1 to 40% of heart saving vegetable juice. The preparation method of the present invention comprises: the pure grain spirit is taken, the alcohol concentration of the pure grain spirit is from 40 to 60%((namely 40 to 60 %Vol), fresh heart saving vegetables are washed clean, and water is drained; juice is extracted from the fresh heart saving vegetables and is filtered, and the pure grain spirit and the heart saving vegetable juice are evenly mixed. The heart saving vegetables of the present invention have the efficiency of blood fat reduction and blood pressure reduction, and the heart saving vegetables are blended with the spirit; on one hand, the health care action of blood fat reduction and blood pressure reduction at the time of drinking can be achieved, and on the other hand, because the heart saving vegetables have cool nature and flavor, the heart saving vegetables and the spirit with the nature and flavor of great heat can learn from others' strengths to make up for weaknesses. Because the alcohol can promote the synthesis of endogenous cholesterin and triglyceride to cause blood fat to rise, the ingredients of the heart saving vegetables are added in the spirit, and can counteract the action of blood fat rise of the spirit.
The growing knowledge of non-digestible oligosaccharide (NDO)-related health benefits has led to the identification of other fermentable carbohydrates which may improve bone balance and bone health parameters. One such carbohydrate is the corn derivative, soluble corn fiber (SCF). Already known for its association with improved intestinal health and influence on colonic microflora content, we have been studying the effects of SCF on calcium absorption and bone health. First we found that soluble corn fiber (SCF) greatly enhanced calcium utilization and bone properties in a growing rat model. Results from this study demonstrated that SCF was capable of increasing bone mineral content, density and bone strength parameters in 4-week old, male rats. Our study in adolescent boys and girls showed a 12% increase in calcium absorption after consuming 12 g SCF for 21 days compared to a control period in a crossover design using a controlled feeding metabolic balance approach. Given these profound changes on calcium absorption and in bone, a logical next step is to study a dose-response effect of SCF on calcium absorption, bone turnover, and gut microflora in free-living adolescents.
Neuropathic pain results from damage to nerves or the brain, and is characterized by symptoms such as allodynia, spontaneous pain, and hyperalgesia. The causes of this type of pain are intricate, which can make it difficult to treat. Sodium aescinate (SA), a natural extract from horse chestnut tree seeds, has been shown to act as a neuroprotector by inhibiting microglia activation. This study aims to explore the therapeutic potential of SA for neuropathic pain and the molecular mechanisms regulated by SA treatment. Through in vivo animal models and experiments, we found that SA treatment significantly reduced mechanical allodynia and heat hyperalgesia in neuropathic pain models. Additionally, SA inhibited O-GlcNAc-transferase (OGT)-induced O-GlcNAcylation (O-GlcNAc) modification in neuropathic pain mice. OGT overexpression could impede the therapeutic effects of SA on neuropathic pain. Further investigation revealed that Toll-like receptor 3 (TLR3), stabilized by OGT-induced O-GlcNAc modification, could activate the Mitogen activated protein kinase (MAPK) signaling pathway. Further in vivo experiments demonstrated that TLR3-mediated p38 mitogen-activated protein kinase (p38MAPK) activation is involved in SA-mediated relief of neuropathic pain. In conclusion, this study uncovers a novel molecular pathway deactivated by SA treatment in neuropathic pain.
BACKGROUND AND OBJECTIVES: Factors associated with cerebral small vessel disease (SVD) progression, including incident infarcts, are unclear. We aimed to determine the frequency of incident infarcts over 1 year after minor stroke and their relation to baseline SVD burden, vascular risks, and recurrent stroke and cognitive outcomes.
METHODS: We recruited patients with lacunar or nondisabling cortical stroke. After diagnostic imaging, we repeated structural MRI at 3-6 monthly intervals for 12 months, visually assessing incident infarcts on diffusion-weighted imaging or FLAIR. We used logistic regression to determine associations of baseline vascular risks, SVD score, and index stroke subtype with subsequent incident infarcts. We assessed cognitive and functional outcomes at 1 year using Montreal Cognitive Assessment (MoCA) and modified Rankin scale (mRS), adjusting for baseline age, mRS, MoCA, premorbid intelligence, and SVD score.
RESULTS: We recruited 229 participants, mean age 65.9 (SD 11.1). Over half of all participants, 131 of 229 (57.2%) had had an index lacunar stroke. From baseline to 1-year MRI, we detected 117 incident infarcts in n = 57/229 (24.8%) participants. Incident infarcts were mainly of the small subcortical (86/117 [73.5%] in n = 38/57 [66.7%]) vs cortical infarct subtype (n = 19/57 [33.3%]). N = 39/57 participants had incident infarcts at 1 visit; 18 of 57 at 2 or more visits; and 19 of 57 participants had multiple infarcts at a single visit. Only 7 of 117 incident infarcts corresponded temporally to clinical stroke syndromes. The baseline SVD score was the strongest predictor of incident infarcts (adjusted odds ratio [OR] 1.87, 95% CI 1.39-2.58), while mean arterial pressure was not associated. All participants with incident infarcts were prescribed an antiplatelet or anticoagulant. Lower 1-year MoCA was associated with lower baseline MoCA (β 0.47, 95% CI 0.33-0.61), lower premorbid intelligence, and older age. Higher 1-year mRS was associated with higher baseline mRS only (OR 5.57 [3.52-9.10]). Neither outcome was associated with incident infarcts.
DISCUSSION: In the year after stroke in a population enriched for lacunar stroke, incident infarcts occurred in one-quarter and were associated with worse baseline SVD. Most incident infarcts detected on imaging did not correspond to clinical stroke/transient ischemic attack. Worse 1-year cognition and function were not associated with incident infarcts.
The application provides a traditional Chinese medicine composition for warming muscles and cold dampness between meridians, and relates to the technical field of traditional Chinese medicines. Comprises the following Chinese medicinal materials: radix Aconiti lateralis Preparata, alismatis rhizoma, radix Paeoniae alba, atractylodis rhizoma, poria, and Glycyrrhrizae radix. The traditional Chinese medicine composition has definite curative effect, strict formula, proper compatibility and capability of cutting the pathogenesis. In the recipe, aconite root is used to take out the pungent heat and the nature of the aconite root, tonifying the kidney and the fire, expelling wind-cold-dampness, and passing through the twelve meridians. Poria is white in color, excretes dampness in a pale manner, enters the lung to purge heat, and downwards passes through the bladder; radix Paeoniae alba and Glycyrrhrizae radix can be added to synthesize radix Paeoniae and Glycyrrhrizae radix decoction for relieving pain, and relieving ischialgia and lumbago. The bighead atractylodes rhizome is added to strengthen the spleen and remove dampness so as to assist in removing dampness. So that the liquorice regulates the medicines to harmonize the spleen and the stomach. The medicines exert the efficacies of monarch, minister, assistant and guide, and treat both principal and secondary aspect of disease. The recipe is commonly used in clinic for treating Chronic Fatigue Syndrome (CFS) such as chronic fatigue, mood disorder, sleep disorder, pain, nephropathy, endocrine and immune diseases, and female gynecological diseases.
PURPOSE: To obtain stabilized tablets of nicorandil useful as a therapeutic agent for angina pectoris by tableting a mixture of nicorandil, a specific water-soluble substance and excipient granules to prevent nicorandil from becoming unstable by conventional tabletting process. CONSTITUTION: (A) Nicorandil is mixed with (B) inositol (BI) or a combination thereof with a sucrose fatty acid ester (BII) and an excipient such as granules containing mannitol and α-form starch and the mixture is tableted to give the objective stabilized tablet of nicorandil. As for the amount of component B, it is preferable that the content of BI is 0.1-5 pts.wt. and that of BII less than 2 pts.wt. per 1 pt.wt. of component A, and the BII has 1-5 HLB.
Under conscience sedation, a nick in the skin is made to mimic marrow aspiration. Laser fiber is inserted into knee over an 18 gauge needle and micro-channels are made into the damaged cartilage.