anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A computer system is disclosed comprising first and second network-connected computing devices, the latter of which is programmed to access both an ontological graph database and a third-party media content resource. Nodes and/or edges in the ontological graph database may be provided with a human- readable name or value which can be extracted and submitted as part of a request to the third party media content resource so that appropriate media content, in terms of being at least sympathetic with the human-readable name or value, can be combined therewith and subsequently displayed, preferably on the first computing device. In use, the second computing device responds to consecutive requests from the first computing system by returning one or more combined display packages, each comprising a human-readable name of an entity defined in the database and sympathetic media content therefor. Any selection or interaction with the displayed package at the first computing device is returned to the second computing device, which repeats the process, eliminating those nodes or edges already having been extracted and displayed as part of a current session. The result, on the first computing device, is that a user is provided with a media-content enhanced navigation through the real-world subjects, topics, themes, events, persons, and the like, which are represented by the nodes and edges in the graph database. This can prove invaluable engaging, and thus providing therapy for, persons with dementia and other cognitive brain function disorders or underdevelopments.
Malaria causes over one million deaths annually. A promising control strategy relies on targeting mosquito populations when they are vulnerable, such as during the dry season. Prolonged dry season during which larval sites are scarce and mosquito populations decline prevail in the Sahel which covers a large part of Mali. How mosquitoes withstand the dry season remains unknown. Some evidence supports the adult estivation hypothesis whereby mosquitoes remain in protected sites, except for sporadic journeys to obtain blood-meals to sustain themselves rather than to produce eggs. Alternatively, mosquitoes do not survive the dry season locally; rather, they migrate from areas where reproduction continues at permanent water bodies. We aim to determine if An. Gambiae estivate during the dry season in the Sahel; and if so, identify their hidden resting sites. As mosquito populations decline, standard sampling techniques yield zero mosquitoes. Because estivating females take blood meals intermittently, the most promising sampling technique is by human landing catch (HLC). Finding a few mosquitoes during the dry season have been reported, but it could not be determined if they were estivating or were migrants from villages, where larval sites persist. This study can resolve this because we captured marked and released over 5000 mosquitoes just before the dry season (November 2008). We aim to collect mosquitoes during the end of the dry season (April 2009) and the onset of the rainy season (June 2009) and find out if they bear marks from the previous wet season. Finding a single marked specimen will be the ultimate proof for the estivation hypothesis. Experiments will take place in the Sahelian village Thierola, Koulikoro Region, Mali, where the dry season exceeds 7 months. The village was chosen because it has no permanent larval sites and is a small community (\< 300 inhabitants) living in 90 houses, allowing collection in all houses in a single day. Thirty adult male residing in Thierola will be recruited as collectors for the HLC. A collector will expose his lower legs to attract mosquitoes. Using a mouth aspirator, mosquitoes will be collected as they land on the collector's legs, ideally, before a blood meal is taken. Collection will be conducted 6pm to 6am for 14 consecutive days in April 2009 and again after the rains begin in June 2009. Collectors will be informed of the proper collecting procedures during the consenting procedure. During the time of year we propose to conduct this work, mosquito populations will be at their minima and any surviving mosquitoes will take blood meals infrequently. Therefore, the HLCs will be conducted when malaria transmission is extremely low and the risk to volunteers essentially nil. In summary, knowledge of how mosquitoes survive the dry season would open novel ways for vector and malaria control.
FIELD: medicine, phytotherapy, pharmacy. SUBSTANCE: invention relates to preparations of vegetable origin. Invention proposes the composition containing borago leaves and stems, nettle leaves and primrose leaves taken in the definite ratio of components. Agent shows curative and prophylactic effect in patients with alimentary tract diseases. EFFECT: valuable medicinal properties of agent. 2 tbl, 3 ex
Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.
FIELD: medicine. SUBSTANCE: method involves placing hen embryo spinal cord ganglion into spinal fluid of a patient. Spinal cord ganglion sensor neuron processes growth factor is evaluated. Growth factor activity rising to 20%, the patient is to be included into epilepsy incidence risk group. Growth factor activity rising to a value greater than 20%, epilepsy is to be diagnosed. EFFECT: higher accuracy of diagnosis at early stage of disease.
McKittrick-Wheelock syndrome (MKWS) is an uncommon clinical manifestation of large, villous, epithelial lesions of the distal colon and rectum. Excessive secretion of electrolyte-rich mucus from these lesions leads to secretory diarrhea, electrolyte disorders and acute renal failure. Several cases of MKWS have been reported since its initial description in 1954. The definitive treatment for the great majority of MKWS cases has consisted of surgical resection of the affected part of the colorectum, usually in the form of a low anterior resection or an abdominoperineal resection with the formation of an ostomy. Recent developments in endoscopic resection techniques now offer new, minimally invasive treatment alternatives for MKWS patients. We present the first reported case in the Western world of MKWS caused by a rectal adenoma with a size of 19 × 10 cm, treated through endoscopic submucosal dissection. Through the lessons learned by this case, as well as by a thorough review of the literature, we discuss this uncommon syndrome, focusing on treatment alternatives.
Pec I block will be given with 10 ml bupivacaine 0.25% which injected between two pectoral muscles and pecs II block will be given with 20 ml bupivacaine 0.25%.which given between pectoralis minor muscle and serratus muscle. Patients will receive ultrasound guided pecs block done after induction and before skin incision.
<P>PROBLEM TO BE SOLVED: To provide an effective external preparation, though it is said that a method having little damage on organisms and environment does not exist in sterilization treatment of fungus fixed to organisms and sterilization treatment of decay fungus of trees has bad influence on trees and ambient surrounding, because conventional agents use heavy metals such as copper for sterilization and a synthetic inhibitor, etc., of cell membrane is used for sterilization treatment of Trichophyton.  <P>SOLUTION: A method for sterilizing fungus is carried out by Fenton reaction producing an active oxygen (hydroxyl radical) which is a strong oxidizing agent by decomposing hydrogen peroxide with a divalent iron. Oxidizing power of the active oxygen breaks cell wall of fungus. Sterilization of fungus is carried out by the oxidizing power. The sterilization method has no bad influence on environment, because the method is carried out by oxidizing power of active oxygen. The method has little influence on living bodies, because the method is carried out by directly applying to, injecting into and permeating into a part infected by fungus.  <P>COPYRIGHT: (C)2009,JPO&INPIT
BACKGROUND: The correlation between lipid profiles and sepsis has received increasing attention. The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) is one of the key lipid profiles. However, in-depth exploration of the correlation between NHHR and the mortality risk of patients with sepsis is limited.
METHODS: Data from the MIMIC-IV (v2.2) database, we review the NHHR relevance and the sepsis severity index using Spearman's correlation analysis. Additionally, we research NHHR associated with sepsis patients' survival rate of 28 days using Cox regression analyses of continuous and categorical models. To further validate our findings, we conducted subgroup and sensitivity analyses.
RESULTS: The study involved 3,142 patients diagnosed with sepsis, according to 28 days after in-hospital survival condition, divided into two groups. In this study, 2932 patients were in the survival group and 210 patients died within 28 days (mortality group). Of note, the mean NHHR of patients in the mortality group exceeded that of the survival group (3.5 vs. 2.9). Additionally, NHHR was positively correlated with the severity index. After adjusting for demographic and laboratory data, an increased NHHR was positively correlated with higher sepsis mortality risk (OR = 1.06; 95% CI: 1.02-1.11; P = 0.013). Subgroup analysis shown the same results. Contributors were be categorized into two groups based on NHHR levels, with a threshold of 2.61. Contrast the mortality risk between low-NHHR group and high-NHHR group, high-NHHR show greater mortality risk on 28-day, 60-day, 90-day, in ICU, and in hospital.
CONCLUSION: Elevated NHHR is to be correlated with an increased risk of mortality in patients with sepsis. Further research on NHHR may contribute to advancements in sepsis prevention and treatment.
New vaccine for the immunological control of fertility in female mammals consists of an aq. soln. of H2O-solubilized zona pellucida (SZP) (prepd. by heating mammalian zone pellucida (ZP) at 65-100 degrees in an aq. medium consisting of buffered saline soln. at pH 7-7.4 until soln. occurs). Also new is an antiserum compsn. for the control of fertility in females consisting of cell-free sera contg. the antibody obtained by injecting into a mammalian host the (SZP) of a distinct donor species, then collecting the cell-free sera contg. serum antibodies. Vaccine is suitable for immunological fertility control of females, and provides a reversible state of infertility without disruption of the normal estrus cycle. Anti-sera compsn. is useful for the passive immunological control of fertility giving short-term infertility and preventing uterine implantation.
This is an open, single-arm, multicenter phase II clinical study to evaluate the efficacy and safety of BEBT-908 for injection in the treatment of relapsed or refractory diffuse large B-cell lymphoma. The study will be divided into two stages: Ⅱa and Ⅱb, stage Ⅱa is an exploratory study, which mainly explores the safe and effective dose, 30 cases are planned to be included in the group, stage Ⅱb mainly evaluates the efficacy and safety of BEBT-908 for injection, according to the preliminary overall efficacy analysis of stage Ⅱa, the sample size of stage Ⅱb is about 90 cases.

In phase Ⅱa and Ⅱb study, the initial dose was 22.5mg/m2, intravenous drip, 21 days as a cycle and 6 cycles as the total treatment cycle. The drugs were given on the 1st, 3rd, 5th, 8th, 10th and 12th day of each cycle. The study process of each subject included three periods: screening period, treatment period and follow-up period after treatment. During the treatment period, all safety items were examined before administration on the first day of each cycle, and the tumor was evaluated every 2 cycles. After the termination of treatment, the subjects will enter the follow-up period. Receive curative effect follow-up every 6 weeks (to tumor progression or other anti-tumor therapy) and survival follow-up every 3 months.
Periodontitis is an inflammatory condition affecting the supporting structures of the teeth. Periodontal conditions may increase the susceptibility of individuals to various systemic illnesses, including Alzheimer's disease. Alzheimer's disease is a neurodegenerative condition characterized by a gradual onset and progressive deterioration, making it the primary cause of dementia, although the exact cause of the disease remains elusive. Both Alzheimer's disease and periodontitis share risk factors and clinical studies comparing the associations and occurrence of periodontitis among individuals with Alzheimer's disease have suggested a potential correlation between these conditions. Brains of individuals with Alzheimer's disease have substantiated the existence of microorganisms related to periodontitis, especially Porphyromonas gingivalis, which produces neurotoxic gingipains and may present the capability to breach the blood-brain barrier. Treponema denticola may induce tau hyperphosphorylation and lead to neuronal apoptosis. Lipopolysaccharides-components of bacterial cell membranes and mediators of inflammation-also have an impact on brain function. Further research could unveil therapeutic approaches targeting periodontal pathogens to potentially alleviate AD progression.
Each patient is prescribed 40 mg of furosemide and 50 mg of hydrochlorothiazide daily for 1 week. Then they receive 40 mg of furosemide daily for 2 weeks.
PURPOSE: Chest pain frequently poses a diagnostic challenge for general practitioners (GPs). Utilizing risk stratification tools might help GPs to rule out acute coronary syndrome (ACS) and make appropriate referral decisions. We conducted a systematic review of studies evaluating risk stratification tools for chest pain in primary care settings, both with and without troponin assays. Our aims were to assess the performance of tools for ruling out ACS and to provide a comprehensive review of the current evidence.
METHODS: We searched PubMed and Embase for articles up to October 9, 2023 concerning adult patients with acute chest pain in primary care settings, for whom risk stratification tools (clinical decision rules [CDRs] and/or single biomarker tests) were used. To identify eligible studies, a combination of active learning and backward snowballing was applied. Screening, data extraction, and quality assessment (following the Quality Assessment of Diagnostic Accuracy Studies-2 tool) were performed independently by 2 researchers.
RESULTS: Of the 1,204 studies screened, 14 were included in the final review. Nine studies validated 7 different CDRs without troponin. Sensitivities ranged from 75.0% to 97.0%, and negative predictive values (NPV) ranged from 82.4% to 99.7%. None of the CDRs outperformed the unaided judgment of GP's. Five studies reported on strategies using troponin measurements. Studies using high-sensitivity troponin showed highest diagnostic accuracy with sensitivity 83.3% to 100% and NPV 98.8% to 100%.
CONCLUSION: Clinical decision rules without troponin and the use of conventional troponin showed insufficient sensitivity to rule out ACS in primary care and are not recommended as standalone tools. High-sensitivity troponin strategies are promising, but studies are limited. Further prospective validation in primary care is needed before implementation.
The invention provides a sublingual pharmaceutical composition containing ibutilide and belongs to the technical field of medicine. The composition contains active component ibutilide or salt thereof and officinal excipient. The ibutilide sublingual pharmaceutical composition is 10-500 mg for per preparation, preferably 50-250 mg and more preferably 80-150 mg, and contains 0.0435-5.22 mg of main drug ibutilide or salt thereof (calculated by ibutilide), preferably 0.087-4.35 mg and more preferably 0.174-2.175 mg. The drug can be rapidly absorbed after administration and has advantages of fast effectiveness, accurate quantity and convenience for usage, so as to avoid first-pass effect of oral medicament and substantially increase bioavailability and curative effect. The production technology for preparing sublingual tablet is stable, repeatable and at low cost, can be used for industrialized production and has good clinic usage value and social benefits. The sublingual administrated preparation provided by the invention is used for treating arrhythmia.
Introduction. Central venous catheter (CVC)-related infection is the main complication observed in patients undergoing hemodialysis with this type of venous access. Objective. To estimate the incidence of non-tunneled CVC-related bacteremia, analyze the frequency of causative agents, and explore associated risk factors in children undergoing hemodialysis. Population and methods. Retrospective study in children receiving hemodialysis via a non-tunneled CVC between June 1st, 2015 and June 30th, 2019. A logistic regression was carried out to assess risk factors that were predictors of CVC-related bacteremia. Independent risk factors were described as odds ratios with their corresponding 95% confidence interval (CI). A value of p < 0.05 was considered statistically significant. Results. A total of 121 non-tunneled CVCs were included in this study. The incidence of bacteremia was 3.15 per 1000 catheter-days. The most commonly isolated microorganism was Staphylococcus epidermidis (16 cases, 51.5%). Prior catheter infection was the only independent risk factor for the development of bacteremia associated with non-tunneled CVC (OR: 2.84, 95% CI: 1.01-7.96, p = 0.04). Conclusions. Prolonged use of non-tunneled CVCs for chronic hemodialysis was associated with a low incidence of bacteremia. Gram-positive microorganisms prevailed among causative agents. A prior CVC infection almost trebled the risk for CVC-related bacteremia in our pediatric population receiving hemodialysis.
The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol and an effective amount of an antioxidant. In one embodiment, the formulation also contains a tonicity modifier. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. Advantageously, the formulations can be prepared without the use of harmful co-solvents or surfactants, and are stable at room temperature over extended periods of time.
The present invention relates to a preparation method of blood-nourishing angelica capsule using eight tastes of Chinese medicine, such as angelica, white peony, prepared rehmanniae, tuckahoe, liquorice (fried honey), lanceolata, milk vetch and hemlock parsley, as raw materials. The preparation method has the main technology that firstly, the white peony and the tuckahoe are pulverized into powder for standby, and are uniformly mixed with water decoction thick paste such as the angelica, the thick paste extracted from hemlock parsley alcohol, the lanceolata, the prepared rehmanniae, etc.; all the materials are decompressed, dried and pulverized for filling the capsule. The present invention overcomes the defects of an original syrup preparation of inconvenient administration, carrying and transportation and high sugar content, and has the advantages of small administration size, stable and controllable quality and wide application people. The preparation technology has the advantage that compared with the syrup preparation, the content of extracted ferulic acid of a main effective component is largely enhanced. A vacuum drying technique with low temperature is adopted for little loss of active components and the guarantee of therapeutic effects. The present invention has the advantages of stable technology, simple operation, short production period, dissolvant saving and energy source saving.
Patients receive ixazomib citrate PO on days 1, 8, and 15, lenalidomide PO QD on days 1-21, and dexamethasone PO on days 1, 8, 15, and 22. Treatment repeats every 28 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo standard of care ASCT after completing 3 cycles of treatment.
It is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and heat waves are lacking. Previous reports revealed that heatstroke induced acute lung injury and pulmonary dysfunction. This study aimed to investigate whether heat exposure induced lung fibrosis and to explore the underlying mechanisms. Male C57BL/6 mice were exposed to an ambient temperature of 39.5 ± 0.5 °C until their core temperature reached the maximum or heat exhaustion state. Lung fibrosis was observed in the lungs of heat-exposed mice, with extensive collagen deposition and the elevated expression of fibrosis molecules, including transforming growth factor-β1 (TGF-β1) and Fibronectin (Fn1) (p < 0.05). Moreover, epithelial-mesenchymal transition (EMT) occurred in response to heat exposure, evidenced by E-cadherin, an epithelial marker, which was downregulated, whereas markers of EMT, such as connective tissue growth factor (CTGF) and the zinc finger transcriptional repressor protein Slug, were upregulated in the heat-exposed lung tissues of mice (p < 0.05). Subsequently, cell senescence examination revealed that the levels of both senescence-associated β-galactosidase (SA-β-gal) staining and the cell cycle protein kinase inhibitor p21 were significantly elevated (p < 0.05). Mechanistically, the cGAS-STING signaling pathway evoked by DNA damage was activated in response to heat exposure (p < 0.05). In summary, we reported a new finding that heat exposure contributed to the development of early pulmonary fibrosis-like changes through the DNA damage-activated cGAS-STING pathway followed by cellular senescence.
Thrombocytopenia can occur with the administration of enoxaparin sodium injection.

Moderate thrombocytopenia (platelet counts between 100,000/mm3 and 50,000/mm3) occurred at a rate of 1.3% in patients given enoxaparin sodium injection, 1.2% in patients given heparin, and 0.7% in patients given placebo in clinical trials.

Platelet counts less than 50,000/mm3 occurred at a rate of 0.1% in patients given enoxaparin sodium injection, in 0.2% of patients given heparin, and 0.4% of patients given placebo in the same trials.

Thrombocytopenia of any degree should be monitored closely. If the platelet count falls below 100,000/mm3, enoxaparin sodium injection should be discontinued. Cases of heparin-induced thrombocytopenia with thrombosis have also been observed in clinical practice. Some of these cases were complicated by organ infarction, limb ischemia, or death [see Warnings and Precautions (5.4)].