anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the face of a rapidly growing population of older, HFpEF patients, there remains a need to identify ideal rehabilitative therapies to enhance improvements in the physical function of these patients. Pharmacological trials in this population have been characterized by a failure to significantly improve exercise tolerance and hard clinical outcomes and this is likely due to their singular cardiovascular focus. Exercise appears to be a promising intervention to improve cardiorespiratory fitness and reduce cardiovascular risk. Further, evidence-based dietary guidelines for patients with heart failure are lacking. Although a high-protein, low-carbohydrate diet is associated with improvements in traditional CV risk markers in patients with heart failure, it may raise cardiovascular risk in this population by adversely affecting endothelial function, increasing susceptibility to myocardial ischemia, and by inducing a pro-inflammatory state due to increased bacterial and LPS translocation through the ischemic gut. Thus, the investigators will explore the effects of the high-carbohydrate, high-fiber DASH diet due to its potential to have salutary effects on vascular risk in this population. In this study, the investigators will examine the singular and combined effects of exercise and a DASH diet in patients with HFpEF on markers of cardiovascular risk.
Reactive oxygen species (ROS)-induced oxidative DNA damages have been considered the main cause of mutations in genes, which are highly related to carcinogenesis and tumour progression. Extracellular vesicles play an important role in cancer metastasis. However, the precise role of DNA oxidative damage in extracellular vesicles (EVs)-mediated cancer cell migration and invasion remains unclear. Here, we reveal that ROS-mediated DNA oxidative damage signalling promotes tumour metastasis through increasing EVs release. Mechanistically, 8-oxoguanine DNA glycosylase (OGG1) recognises and binds to its substrate 8-oxo-7,8-dihydroguanine (8-oxoG), recruiting NF-κB to the synaptotagmin 7 (SYT7) promoter and thereby triggering SYT7 transcription. The upregulation of SYT7 expression leads to increased release of E-cadherin-loaded EVs, which depletes intracellular E-cadherin, thereby inducing epithelial-mesenchymal transition (EMT). Notably, Th5487, the inhibitor of DNA binding activity of OGG1, blocks the recognition and transmission of oxidative signals, alleviates SYT7 expression and suppresses EVs release, thereby preventing tumour progression in vitro and in vivo. Collectively, our study illuminates the significance of 8-oxoG/OGG1/SYT7 axis-driven EVs release in oxidative stress-induced tumour metastasis. These findings provide a deeper understanding of the molecular basis of cancer progression and offer potential avenues for therapeutic intervention.
PURPOSE: The duration of response to treatment is a significant prognostic indicator, with early recurrence (ER) often predicting poorer survival outcomes in nasopharyngeal carcinoma (NPC) survivors. This study seeks to elucidate the factors contributing to the onset of ER following radiotherapy in NPC survivors.
METHODS: This investigation encompassed 2,789 newly diagnosed NPC patients who underwent radical intensity-modulated radiotherapy. Ordinal logistic regression analysis was employed to evaluate the independent predictors of earlier recurrence. A machine learning-based prediction model of NPC recurrence patterns was developed. Tumorous RNA-sequencing (in-house cohort: N = 192) and biological tipping point analysis were utilized to infer potential molecular mechanisms associated with ER.
RESULTS: Our results demonstrated that ER within 24 months post-initial treatment was the optimal time frame for identifying early malignant progression in NPC survivors. The ER cohort (150 of 2,789, 5.38%) exhibited a notably short median overall survival of 48.6 months. Multivariate analyses revealed that male gender, T4 stage, local or regional residual disease, detectable pre- and post-radiotherapy EBV DNA, and the absence of induction chemotherapy were significant predictors of earlier recurrence. The machine learning-based predictive model further underscored the importance of tumor-related factors in NPC recurrence. Moreover, ER emerged as a pivotal stage in NPC progression, with 15 critical transition signals identified potentially associated with the negative modulation of the immune response.
CONCLUSIONS: Our comprehensive analysis of NPC recurrence patterns has unveiled insights into the key factors driving ER and provided novel insights into potential early warning biomarkers and the mechanisms underlying NPC progression.
Levodopa carbidopa intestinal gel infusion. Diurnal infusion from 7.a.m to 11 p.m.
Tolazamide tablets are indicated as an adjunct to diet to lower the blood glucose in patients with noninsulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

In initiating treatment for noninsulin-dependent diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed and cardiovascular risk factors should be identified and corrective measures taken where possible.

If this treatment program fails to reduce symptoms and/or blood glucose, the use of an oral sulfonylurea or insulin should be considered. Use of tolazamide must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitute for diet or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient thus requiring only short-term administration of tolazamide.

During maintenance programs, tolazamide should be discontinued if satisfactory lowering of blood glucose is no longer achieved. Judgments should be based on regular clinical and laboratory evaluations.

In considering the use of tolazamide in asymptomatic patients, it should be recognized that controlling the blood glucose in noninsulin-dependent diabetes has not been definitely established to be effective in preventing the long-term cardiovascular or neural complications of diabetes.
The fast growth of Decision Neuroscience is contributing to unveil the cognitive processes underlying choices and their neural bases. The results obtained so far show that decision-making involves neural mechanisms underpinning a complex balance between automatic appetitive or aversive drives generated by subcortical structures, and processes of executive control centered in fronto-parietal brain networks. While the role of meso-limbic structures in reinforcement learning have been widely investigated, it is much less clear to what extent are choices shaped by a) individual differences in executive skills; b) contextual factors potentially interfering with such skills, such as knowing that the outcome of those choices will impact only on one's own vs. another's welfare. This a critical gap, since executive abilities are known to decline even in physiological ageing, thus potentially interfering with the quality of choices. On this ground, this single center non-interventional fMRI study aims to provide novel insights into the relationship between executive and decision-making skills, and their possible changes with ageing, in 150 healthy individuals. This goal will be pursued by combining a behavioral assessment of decision-making and executive skills with a multimodal fMRI session including data concerning a) brain activity associated with decision-making and executive functioning in social vs. non-social contexts, b) brain structural morphometry (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging). The behavioral assessment will involve the main metric of decision-making (e.g., risk aversion, loss aversion, delay discounting) and executive functioning (e.g., selective attention and inhibitory control). MRI data will unveil the neural bases of individual differences in decision-making and executive performance in terms of performance-related patterns of brain activity, structure and connectivity. Results will provide an useful baseline for investigating alterations of decision-making and executive functioning, and of their neural bases, in pathological conditions.
In persons with type 1 diabetes (T1DM), hypoglycemia is the major limiting factor in achieving optimal blood glycemic control. All persons with T1DM are at risk for hypoglycemia (blood glucose level \< 70 mg/dl), which is life-threatening and accompanied by serious physical and psychological symptoms, resulting in a profound fear of hypoglycemia (FOH) and reduced quality of life. Young adults with T1DM are at greater risk for FOH and have worse glycemic control and self-management behavior than other age groups with T1DM. The investigator's preliminary research identified that 77% of young adults with T1DM reported FOH, and FOH resulted in increased glycemic variability. Glycemic variability (GV) is the minute-to-minute fluctuation in blood glucose that can be missed if looking only at A1C, a longer-term measure. Increased GV is dangerous because it is associated with cardiovascular events and diabetes complications. A major gap exists in how to manage FOH as a component of diabetes self-management. The Investigators specifically aim to: (1) determine the feasibility and acceptability of a fear reduction program in young adults with T1DM, who experience FOH; and (2) determine the impact of an 8-week cognitive behavioral therapy (CBT)-based intervention on the outcomes: FOH, self-management behavior, glycemic control, and GV. To achieve these aims, the investigators propose a randomized controlled trial in 50 young adults aged 18 to 35 years with T1DM. At completion, FOH will be measured and glycemic patterns will be analyzed to determine differences between the FREE and control groups. Findings from this proposed pilot study will serve as the foundation for a larger clinical trial to reduce FOH and improve self-management, glycemic control, and GV. This program of research promises to reduce the development of diabetes complications and improve quality of life for young adults with T1DM.
Participants receive an online individualised exercise programme to complete over the internet twice per week. Exercises can be a combination of aerobic, strengthening and balance exercises. Participants receive a weekly phone call from a physiotherapist for the first two weeks to check on progress. After this, every 2 weeks online exercise diaries are remotely monitored by a physiotherapist and exercise programmes progressed as appropriate.
Sham PtaVNS (fictive stimulation), twice daily, 30 minutes each time over 6 months. Followed by 6 months home excercice program, physiotherapy twice a week, and continuous low frequency antidromic pelvic neuromodulation (CAPN).
Studies have shown in the blood of patients with COVID-19 there was a marked increase in the cytokines and chemokines interleukin 1β (IL-1β), interferon-γ (IFN-γ), interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1) and interleukin-4 (IL-4). Consequently, treatments that reduce cytokine/chemokine production that result in a less severe course of disease could be potentially beneficial. Melatonin, a pineal hormone, has been shown to have anti-inflammation, anti-oxidation and immune enhancing features. In multiple animal models of lung injury, Melatonin supplementation has been shown to decrease the number of inflammatory cells, reduce the levels of the cytokines IL-4, IL-5, IL-13 and TNF-a and reduce nitric oxide and hydroxyl radical concentrations. We propose a dose ranging pilot study to assess the safety and efficacy of melatonin in reducing hospitalization in COVID-19 patients with mild-moderate disease. A total of 50 participants will be randomized to the intervention arm (melatonin: 3 mg, or 30 mg three times a day for 14 days) or control arm (placebo) in a 2:2:1 fashion using a permuted block randomization scheme. Analyses will be performed with a focus on estimation of specific clinically important parameters, including safety and preliminary evidence of activity, for planning of a subsequent definitive comparative trial designed to fully assess efficacy.
<P>PROBLEM TO BE SOLVED: To automatically perform association of photographed images of the diseased part etc. of a patient photographed with a digital camera and a file of an electronic medical record etc. of the patient.  <P>SOLUTION: A file sever unit memorizes the access date and time when prescribed file is accessed. The file server unit distinguishes presence of relevancy by comparing the photographed date and time of photographed image photographed with a digital camera and the access date and time. When it is distinguished that there is relevancy, the file is associated with the photographed image.  <P>COPYRIGHT: (C)2009,JPO&INPIT
A method and system is invented for continuous monitoring, real-time analysis, and automated and personalized training of exercise. The system embodies a multi-sensor data acquisition system to measure body sounds, body signs, vital signs, motions, and machine settings continuously and automatically. The system is able to capture the body sounds and other vital signs, analyze them, and report and display summarized results. The signal processing functions utilize a unique signal separation and noise removal methodology by which authentic signals can be extracted from interfered signals and in noisy environments, even when signals and noises have similar frequency components or are statistically dependent. 
     The method and system will facilitate continuous monitoring, real-time analysis, and computerized evaluation of level of effort, physical stress, and resulting fatigue during physical activity or exercise. In addition, based on body sound data, or in combination with other monitored physiological signals, and knowledge of the individual and exercise being performed, the system will evaluate the person's physical performance and then act as an automated coach to guide exercise intensity and duration thereby optimizing and individualizing the training process. The invention is especially targeted, but not limited to, cardiopulmonary monitoring for athletes for improving the efficiency and safety of exercise, rehabilitation programs for out-of-shape individuals, and routine exercise of the general population.
NEW MATERIAL:The compound of formula (X is Cl or Br). USE:Synthetic intermediate of various organic compounds, an agent for imparting lasting perfume or a perfume modifier. PREPARATION:The compound of formula can be prepared by halogenating 1,1,2,2-tetramethylpropanol with a halogenation agent (e.g. hydrochloric acid, hydrogen bromide water, etc.) at 0-100 deg.C for 0.5-24hr. The 1,1,2,2- tetramethylpropanol used as the starting material can be synthesized easily from 3,3-dimethyl-2-butanone and methyl magnesium halide.
The invention provides a preparation method for a dry extract of total saponins of rehmannia leaves, which comprises the following steps: a microwave drying machine is used to dry a rehmannia leaf extract under a vacuum condition, and water evaporates and is drawn out by vacuum after the rehmannia leaf extract absorbs microwave energy. The whole drying process has the advantages of short time and low environmental temperature, and the obtained dry extract is a medium with uniform and loose pores and has the advantages of light color, low water content, good solubility and the like. The method has the advantages of short operating process and convenient cleaning, facilitates the production of multiple batches and multiple varieties and meets the GMP requirements. The preparation method provided by the invention can realize that microwave drying power can be automatically selected to dry the extract in different periods in the drying process and the vacuum degree can be simultaneously subjected to on-line adjustment in the drying process. Compared with the common vacuum hot-air oven method, the quality of the dry extract of total saponins of rehmannia leaves obtained by the invention is greatly improved, thereby being beneficial to the subsequent preparation operation. Besides, the drying time is greatly shortened, the labor intensity is lowered, and the production efficiency is improved.
The present invention relates to a skin care cream used for reducing the blood sugar of patients suffering from noninsulin-dependent diabetes mellitus and the technical field of a production method thereof. The skin care cream comprises skin care cream radical, and is characterized in that the skin care cream radical comprises suifonylurea medicines of reducing blood sugar, of which the mass percentage is 0.1% to 2.8%, or/and biguanide medicines of reducing blood sugar, of which the mass percentage is 0.1% to 2.8%, or/and insulin secretion promoting agent medicines of reducing blood sugar, of which the mass percentage is 0.06% to 1.6%, or/and plant/ traditional Chinese medicine extract of which the mass percentage is 0.2% to 8% and skin penetrating components of which the mass percentage is 1% to 10%. Simultaneously, the present invention also provides a production method for producing the skin care cream. The present invention has the advantages of reliable and safe treatment, easy use, ideal effect and face beautification. Simultaneously, the present invention has the functions of reducing body fluid blood sugar in a short time, improving the responsiveness of beta-cell to glucose and the combination of insulin to target tissue for long term, etc.; when the present invention is used for long term, the present invention can strengthen the ability of in vivo insulin for regulating blood sugar, can reduce the blood sugar of patients suffering from diabetes mellitus, has the effect of treating diabetes mellitus, and is especially suitable for old patients and female patients to use.
In a medical information management system, a management server which manages medical information generated in medical facilities is connected to client terminals in the medical facilities. The management server includes a first storage, a second storage, a first generator and a second generator. The first storage stores permission information including a disclosee. The second storage stores a partner key with respect to each partner to share the medical information, the partner being a candidate of the disclosee. In response to a download request of the medical information from one of the client terminals, the first generator generates a content key and encrypts the medical information using the content key. The second generator encrypts the content key and the permission information of the encrypted medical information by using the partner key of the disclosee included in the permission information.
BACKGROUND: The refractory and disabling nature of sensory disorders after stroke seriously affects patients' daily lives and reduces hospital turnover. Acupuncture, as an alternative therapy, is commonly used in combination with rehabilitation training to improve sensory disorders. To compare the effects of different acupuncture-related treatments combined with rehabilitation training on sensory impairment and the daily living ability of patients with stroke, we conducted a network meta-analysis to provide evidence-based findings for clinical practice.
METHODS: Randomized controlled trials on the treatment of sensory disorders in patients with stroke were systematically retrieved from several databases, including China National Knowledge Infrastructure (CNKI), China Science and Technology Journal(VIP), Wanfang Database, Chinese Biological Medical (CBM), PubMed, Embase, Web of Science, Cochrane Library, and Clinical trials. The retrieval period ranged from January 2012 to December 2023. Two independent reviewers screened the included literature, extracted the data, and assessed the risk quality using Cochrane Handbook 5.1.0 and ReviewManager 5.4.1. Stata16.0 software was employed for data analysis. The study protocol was registered in PROSPERO: CRD42023389180.
RESULTS: After screening, 20 studies were included, involving a total of 1999 subjects. The network meta-analysis results indicate that, compared to standard rehabilitation, acupuncture plus massage plus rehabilitation showed the most significant reduction in Numbness Syndrome Scores (MD = -0.71(-1.11,-0.31)). Acupuncture combined with rehabilitation demonstrated the most substantial improvement in Sensory Impairment Scores (MD = -0.59,(-0.68,-0.51)) and daily living ability of patients (MD = 17.16,(12.20,22.12)).
CONCLUSIONS: In comparison to standard rehabilitation, the combination of acupuncture-related treatments and modern rehabilitation training not only improves the symptoms of sensory impairment and numbness after stroke but also enhances the daily living ability of patients, especially when acupuncture is combined with rehabilitation. However, further demonstration is required to strengthen these conclusions.
The invention provides a composition for caring and relieving skin barrier, a preparation method and application thereof. Through the compound use of the algae oligosaccharides and the hydrolyzed algae gum, the film can be formed on the surface of the skin, the penetration of the stimulating components into the skin is reduced, and the stimulation of various sensitization components such as common preservative, polyalcohol, essence and the like is obviously and effectively reduced. And can reduce contaminant particle adhesion through durable film formation protection. Meanwhile, based on the algae oligosaccharides and the hydrolyzed algin, the skin barrier and the skin protection can be enhanced. Can also relieve the existing inflammation symptoms of the skin. Based on the composition of the algae oligosaccharides and the hydrolyzed algae gum, the protection and the safety of the skin care product in the use process can be obviously improved.
About half of patients who experience a traumatic spinal cord injury (SCI) have still motor and/or sensory function below the level of the lesion. A large proportion of these patients become ambulatory within the first six months after the SCI. In order to optimally train the walking function patients are partially unloaded from their body weight while they walk on a moving treadmill. In severe cases therapists have to assist the leg movements which is an exhaustive work limiting training time. In the last few years robotic devices have been developed which enable longer training time. Studies evaluating the training of patients with hemiparesis showed that longer training time is associated with a better outcome. The present study aims at evaluating the effect of training time within the robotic device on the recovery of ambulatory function. Subject with an acute incomplete SCI will be included. The intervention consist of a walking training which lasts at least 50min, the training of the control group last at maximum 25min. Both groups will undergo 3-5 trainings per week. Group assignment will be performed at random. The study lasts for 8 weeks. The primary outcome will be the self selected walking speed which will be assessed bi-weekly during the training period and 4 months later.