anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject stable solution preparation from which no insoluble products deposit and no precipitates form by containing calcium salts of sennoside A and B. SOLUTION: This drug contains at least one of calcium salts of sennoside A and B useful as a mild cathartic and carboxylic acids or their salts. Further, a preservative agent and an auxiliary are formulated thereto when necessary to adjust an aqueous solution at pH5-8. The salts of sennoside A and B are contained in an amount of 0.2-55mg/ml as the sennoside A and B. The carboxylic acids or their salts are contained in an amount of 1-80mg/ml. An aqueous solution preparation containing 12-24mg as calcium salts of sennoside A and B is taken once a day for adult. It is a preparation capable of easily administrating to young children and aged men.
Occasionally, patients undergoing dialysis develop acute severe hypotension that requires interruption of dialysis within minutes of initiating every dialysis session. Although the underlying causes of recurrent intradialytic hypotension are evaluated extensively, including dialysis-associated allergic reactions or other possible causes, the definitive cause is sometimes missed. Dialysis is a life-sustaining procedure; therefore, prompt identification and management of the underlying cause of dialysis intolerance are crucial. Herein, we report three cases of patients undergoing dialysis who presented with hypereosinophilia-associated acute intradialytic hypotension. All three patients developed acute severe hypotension within minutes after the start of every dialysis session. The prescriptions for dialysis were changed, but episodes of intradialytic hypotension persisted. Pretreatment with methylprednisolone given intravenously before the dialysis session was also ineffective. All patients had hypereosinophilia (> 1500/μL) of different etiology. Eosinophil-lowering therapy with 0.5 mg/kg of prednisolone given orally daily was initiated, and all of them could restart dialysis without any hypotensive episodes within a few days. Our case report and literature review indicated that hypereosinophilia, regardless of its etiology, could result in severe acute hypotension shortly after the start of dialysis session. The oral administration of prednisolone daily was highly effective on hypereosinophilia-associated intradialytic hypotension, while pretreatment with intravenous corticosteroid therapy just before dialysis had no effect. Hypereosinophilia-associated acute intradialytic hypotension is an under-recognized condition; therefore, clinicians need to be aware of this clinical entity and initiate effective treatment strategies. We also provide a brief summary of previously published cases.
This arm will include the next 6 participants. In this group, a tube with a camera will be inserted past the ear drum, by making a small hole in the ear drum, to see the electrode as it goes into the cochlea.
Many studies have stressed the importance of psychosocial determinants of health such as food insecurity, housing instability, and education level, as important drivers of health outcomes. Western Health developed a set of nine screening questions (the Western 9) based on psychosocial measures to profile patients enrolled in the HealthLinks Chronic Care initiative. An aggregate score was then converted into a Low, Medium and High risk profiles. The aim of the study was to see if the Western 9 questions added additional discriminative power to existing risk of readmission algorithms. Results show that the inclusion of the risk profiles significantly improved model fit and calibration compared to a baseline risk model. Suggestions for further refinement include developing weighted indices for the Western 9 to improve model fit.
BACKGROUND AND AIMS: Early identification of cardiac structural abnormalities indicative of heart failure is crucial to improving patient outcomes. Chest X-rays (CXRs) are routinely conducted on a broad population of patients, presenting an opportunity to build scalable screening tools for structural abnormalities indicative of Stage B or worse heart failure with deep learning methods. In this study, a model was developed to identify severe left ventricular hypertrophy (SLVH) and dilated left ventricle (DLV) using CXRs.
METHODS: A total of 71 589 unique CXRs from 24 689 different patients completed within 1 year of echocardiograms were identified. Labels for SLVH, DLV, and a composite label indicating the presence of either were extracted from echocardiograms. A deep learning model was developed and evaluated using area under the receiver operating characteristic curve (AUROC). Performance was additionally validated on 8003 CXRs from an external site and compared against visual assessment by 15 board-certified radiologists.
RESULTS: The model yielded an AUROC of 0.79 (0.76-0.81) for SLVH, 0.80 (0.77-0.84) for DLV, and 0.80 (0.78-0.83) for the composite label, with similar performance on an external data set. The model outperformed all 15 individual radiologists for predicting the composite label and achieved a sensitivity of 71% vs. 66% against the consensus vote across all radiologists at a fixed specificity of 73%.
CONCLUSIONS: Deep learning analysis of CXRs can accurately detect the presence of certain structural abnormalities and may be useful in early identification of patients with LV hypertrophy and dilation. As a resource to promote further innovation, 71 589 CXRs with adjoining echocardiographic labels have been made publicly available.
In post marketing experience, severe and occasionally incapacitating bone, joint, and/or muscle pain has been reported in patients taking bisphosphonates. However, such reports have been infrequent. This category of drugs includes pamidronate disodium. The time to onset of symptoms varied from one day to several months after starting the drug. Most patients had relief of symptoms after stopping. A subset had recurrence of symptoms when rechallenged with the same drug or another bisphosphonate.
VERAPAMIL SHOULD BE GIVEN AS A SLOW INTRAVENOUS INJECTION OVER AT LEAST A TWO-MINUTE PERIOD OF TIME. (See Dosage and Administration.)

Hypotension: Intravenous Verapamil often produces a decrease in blood pressure below baseline levels that is usually transient and asymptomatic but may result in dizziness. Systolic pressure less than 90 mm Hg and/or diastolic pressure less than 60 mm Hg was seen in 5%-10% of patients in controlled U.S. trials in supraventricular tachycardia and in about 10% of the patients with atrial flutter/fibrillation. The incidence of symptomatic hypotension observed in studies conducted in the U.S. was approximately 1.5%. Three of the five symptomatic patients required pharmacologic treatment (norepinephrine bitartrate IV, metaraminol bitartrate IV, or 10% calcium gluconate IV). All recovered without sequelae.

Extreme bradycardia/asystole: Verapamil affects the AV and SA nodes and rarely may produce second- or third-degree AV block, bradycardia, and, in extreme cases, asystole. This is more likely to occur in patients with a sick sinus syndrome (SA nodal disease), which is more common in older patients. Bradycardia associated with sick sinus syndrome was reported in 0.3% of the patients treated in controlled double-blind trials in the U.S. The total incidence of bradycardia (ventricular rate less than 60 beats/min) was 1.2% in these studies. Asystole in patients other than those with sick sinus syndrome is usually of short duration (few seconds or less), with spontaneous return to AV nodal or normal sinus rhythm. If this does not occur promptly, appropriate treatment should be initiated immediately. (See Adverse Reactions including suggested treatment of adverse reactions.)

Heart failure: When heart failure is not severe or rate related, it should be controlled with digitalis glycosides and diuretics, as appropriate, before Verapamil is used.

In patients with moderately severe to severe cardiac dysfunction (pulmonary wedge pressure above 20 mm Hg, ejection fraction less than 30%), acute worsening of heart failure may be seen.
Youth with a chronic medical condition (CMC) are often affected by comorbid mental disorders. Resilience-strengthening interventions can protect youth's mental health, yet evidence-based programs remain scarce. To address this lack, this study aimed to evaluate the feasibility of a dual approach combining app-based resilience training and cognitive behavioral group coaching. Fifty-one youths with CMC treated at a German university children's hospital aged 12-16 years were recruited. They were randomly assigned to a combined app game and coaching intervention or sole app gameplay. At pre-, post-intervention, and at a 2-month follow-up resilience, automatic negative thoughts and an app and coaching evaluation were assessed. Feasibility was defined as a recruitment rate of 70%, an 85% adherence rate for the REThink game, and 70% participation in both coaching sessions. Feasibility criteria were reached for coaching participation but not for recruitment or app adherence. While both the REThink game app and coaching intervention had high acceptance rates among youth with CMC, participants receiving additional coaching sessions showed higher satisfaction and adherence rates. Participants preferred remote to in-person meetings. The findings support a combination of a gamification app approach with online group coaching. Group coaching can improve adherence while online options increase accessibility. Future research should focus on testing in diverse participant samples, language, and age-adapted updates of the REThink game app. These findings provide guidance for increasing adherence in future intervention studies in youth with CMC cohorts.
The invention discloses a Chinese herbal medicine composition for relieving sore throat, and belongs to the technical field of medicine processing. The Chinese herbal medicine composition is prepared from dendrobium nobile, dayflower, solidago virgaurea, Japanese ardisia herb, fructus perillae, liquorice, artemisia seed powder, EM original dew and the like. The dendrobium nobile is capable of promoting the secretion of saliva or body fluid, tonifying stomach, nourishing yin, clearing away heat, reinforcing yin and boosting essence, and is suitable for fire excess from yin deficiency, vexation heat and thirst of patients with throat diseases; the dayflower and the solidago virgaurea are capable of dispelling wind, clearing away heat and toxic materials, and relieving swelling and pain; the fructus perillae is capable of eliminating phlegm, depressing qi and relieving asthma; the medicines are in compatibility for strengthening the body resistance to eliminate pathogenic factors to prevent and treat the pharyngitis diseases. The Chinese herbal medicine composition is suitable for treatment of acute and chronic tonsillitis and various demonstration pharyngitises. The artemisia seed powder is used as a binder, also has the efficacies of dispelling wind and eliminating dampness, clearing away heat and toxic materials and relieving swelling, and is beyond comparison than other pharmaceutical excipients. The EM original dew is capable of removing inflammatory, sterilizing, removing fishy smell and peculiar smell, preventing decay, preserving freshness, and decomposing toxic and harmful substances, and is better than other preservatives.
PURPOSE:To obtain a cosmetic giving excellent moisturizing effect and emollient effect to the skin, exhibiting excellent cosmetic effect such as moisture-keeping, skin-beautifying and aging-preventing effects and useful as a foundation cosmet ic, etc., by compounding an extract obtained from a marine phanerogam. CONSTITUTION:Marine phanerogam such as Zostera marina (general term of spermatophytic plants grown in marine, belonging to family Potamogetonaceae, order Alismataceae) is collected. After removing foreign materials, the whole grass of the collected plant is optionally dried in the sun or with a drier, etc., cut into small pieces and extracted e.g. by immersing in an extraction solvent to obtain an extract having high moisture-retaining power and excellent tyrosinase suppressing action, anti-oxidation action and ultraviolet absorption. A cosmetic giving moisture to the skin, preventing spots and speckles, suppressing the generation of lipid peroxide to prevent the skin troubles and keeping the skin in fresh state can be prepared by compounding the above extract. A bathing agent containing the extract has excellent effect to keep the warmth of the body during and after bathing.
Butyrylcholinesterase (BChE or BuChE) is a cholinesterase enzyme that is very similar to acetylcholinesterase (AChE). However, though the role and function of AChE in the human body are widely studied and known, BChE is usually referred to as an 'orphan enzyme' because its specific physiological role is still under question. Lastly, it has been found, however, that BChE has more specific functions than it was previously believed and acetylcholine (ACh), which will be further analyzed, can affect the immune system and is associated with inflammation-related events. Butyrylcholinesterase is an enzyme that for several years was not considered to have a specific physiological role but lately, it has been observed that plays an important role in inflammation as acetylcholine is a major player of the 'cholinergic anti-inflammatory pathway' inhibiting inflammation. It has been proved that BChE activity can be affected by several diseases. Low-grade inflammation is associated with an increase of its levels whereas a reduction is observed when systemic inflammation is present. However, future research is needed in order to be widely used in clinical practice as a biomarker for several pathological conditions involving inflammation. Therefore, the aim of this study is to present information about butyrylcholinesterase, its function, and its role in the human body, highlighting its association with inflammation analyzing past studies about this subject. The Investigators prospectively evaluate patients undergoing elective procedures for colorectal diseases. Blood samples are collected preoperatively (at day 0), post-operatively in the recovery room (day 1), and on the subsequent four days (days 2, 3, 4, and 5) for assessment of BChE, C-reactive protein, and white blood cell concentrations. The same surgical team operates all patients and is blinded to the study. Patients are monitored for post-operative infection by using standard laboratory and clinical methods. If surgical site infection (SSI) is suspected the wound is swabbed and empirical antibiotics are started. The aim of the current trial is to study whether BChE is a reliable marker for the presence of SSI in patients undergoing colorectal surgery.
Participants in this single-arm study will receive Fermented Papaya Preparation (FPP), administered as a 3-gram dose taken three times daily (morning, afternoon, and evening) for 8 weeks. Assessments will be conducted at three time points: baseline, within 24 hours after initial FPP administration (short-term), and after 8 weeks (long-term). This arm investigates the association between FPP and driving performance, focusing on cognitive and psychomotor functions such as attention, memory, reaction time, and executive function using a high-fidelity driving simulator.
<P>PROBLEM TO BE SOLVED: To prepare a hair grower which has good preparation stability, is free from problems such as undesired side effects and scalp irritation, and can exhibit an excellent hair-growing effect.  <P>SOLUTION: This hair grower comprises one or more extracts selected from the extracts of Lentinus edodes (Berk.) Singer ; Echinacea angustifolia DC. or Echinacea purpurea Moench, Prunus domestica Lind., bean sprout (excluding adlay sprout), and Gynostemma pentaphyllum (Thunb.) Makino, which have high vascular endothelial cell growth factor (VEGF) production-promoting effects. Consequently, the hair grower induces revascularization on the peripheries of hair follicles to promote the transfer from the resting stage of the hair follicles to the growth stage or extend the growth stage of the hair follicles, thereby capable of giving the excellent hair-growing effect.  <P>COPYRIGHT: (C)2004,JPO
Alpha-1 Antitrypsin Deficiency (AATD, Alpha-1) is the best established genetic risk factor for chronic obstructive pulmonary disease (COPD) and liver disease. Clinical presentation is heterogeneous in most genotypic populations of alpha-1 antitrypsin deficiency (AATD) and genetic variation in the Alpha-1 gene has been incompletely studied. Rare gene alterations that predispose to COPD risks of classic AATD in individuals without a classic homozygous deficiency genotype have not been studied and are important in understanding, testing and treating at-risk populations. Investigators hypothesize that SERPINA1 gene sequencing will find important sequence variations in previously assessed MZ individuals who have COPD compared to age, race, sex, AAT level and smoking status matched MZ individuals who do not have COPD.

The Alpha-1 Carrier Genomics study is a pilot study that will enroll up to 150 MZ individuals. COPD+ and COPD- individuals will be matched on age, sex, race and smoking history. Presence and severity of COPD is assessed by a COPD severity score on questionnaires. Participants will be mailed a test kit to obtain and return a blood sample by finger stick for the purpose of SERPINA1 gene sequencing. Gene sequencing will identify, if present, genomic signatures that may correlate with COPD in this cohort. Participants will receive their results and access to genetic counseling at the conclusion of this study.
When administered intravenously, these solutions provide a source of water and electrolytes. 

Solutions which provide combinations of hypotonic or isotonic concentrations of sodium chloride are suitable for parenteral maintenance or replacement of water and electrolyte requirements. 

Isotonic concentrations of sodium chloride are suitable for parenteral replacement of chloride losses that exceed or equal the sodium loss. Hypotonic concentrations of sodium chloride are suited for parenteral maintenance of water requirements when only small quantities of salt are desired. A hypertonic concentration of sodium chloride may be used to repair severe salt depletion syndrome. 

Sodium chloride in water dissociates to provide sodium (Na +) and chloride (Cl −) ions. Sodium (Na +) is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Chloride (Cl −) has an integral role in buffering action when oxygen and carbon dioxide exchange occurs in the red blood cells. The distribution and excretion of sodium (Na +) and chloride (Cl −) are largely under the control of the kidney which maintains a balance between intake and output. 

Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirements range from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). 

Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na +) plays a major role in maintaining physiologic equilibrium.
PURPOSE: Cosmetics for hair are provided, to make the hair be glossy and smooth and to recover the damaged hair. CONSTITUTION: A cosmetics for hair comprise 0.01-5.0 wt% of ketarose derivatives which are cationized by quaternary ammonium salts; and 0.1-50.0 wt% of silicon derivatives. Preferably the ketarose derivatives are prepared by using alpha-ketarose or gamma-ketarose, and the quaternary ammonium salts are the compounds represented by the formula 1, wherein R¬1 is independently an alkyl group of low molecular weight; R¬2 is an alkyl group of C1-C20 or an alkenyl group of C2-C20; R¬3 is an alkylene group of C-C24 or a hydroxyalkylene group; X is a halogen atom; Y is a reactive group; and R¬3 and Y can form a glycidyl group together. Preferably the silicon derivatives are the polymeric silicon derivative represented by the formula 2 and the amino modified polymeric silicon or ammonium modified polymeric silicon represented by the formula 3. In the formulas 2 and 3, R¬4 and R¬6 are independently a methyl or phenyl group (All the R¬4s or all the R¬6s are not a phenyl group.); R¬5 is a methyl or hydroxy group; R¬7 is a methyl group, a hydroxy group or R¬8; n is an integer of 3,000-20,000; and x and y are independently plus integer, x+y is 3,000-20,000 and y/x is 1/500 - 1/10,000. R¬8 is R¬9Z, wherein R¬9 is an alkylene group of C3-C6; and Z is an amino or ammonium group.
Hip fracture patients older or equal to 65 years of age, who receive clopidogrel, will be randomly assigned to undertake surgery under general anesthesia in the first 48 hours. Anesthetics to be used are propofol, fentanyl and rocuronium. Maintenance will be achieved with remifentanyl and propofol (TIVA) and the depth of anesthesia will be monitored by BIS. Morphine will be administered bolus IV immediately postoperatively.
Experimental intervention: Low anterior resection for rectal cancer \< 12 cm from the anal verge with total mesorectal excision (TME), ligation of the inferior mesenteric artery, mobilization of the splenic flexure, radical lymph node dissection and side-to-end colorectal/ coloanal anastomosis (STE). The blind end of the descending colon is closed with a linear stapler. The length of the blind end is measured and the integrity of the anastomosis is tested intraoperatively. The intended minimal distal clearance margin from the tumor is 2 cm. A protective loop ileostomy will be performed regularly which is intended to be closed 3 months postoperatively.
Participants undergo Endoscopic Sleeve Gastroplasty (ESG). Following the 6-week transitional diet after undergoing the ESG procedure, participants will start the lifestyle intervention.
In cirrhosis, up to 10% of patients develop refractory ascites. TIPS (transjugular intrahepatic portosystemic shunt) is the first-line therapy for these patients. However, 30% will go on to develop hepatic encephalopathy (HE) as a consequence of TIPS, and there is no effective method to predict this outcome. Oral glutamine challenge (OGC) is used to functionally assess ammonia metabolism, and the severity of porto-systemic collateralization, and it has been used to predict overt HE. Psychometric tests (i.e. Psychometric Hepatic Encephalopathy Score \[PHES\] and inhibitory control test) allow the identification of covert forms of HE and can also predict overt HE. Severe sarcopenia may also predispose patients to HE. The aim of the present study is to assess if both the degree of impairment in ammonia metabolism as estimated with the OGC, and cognitive status as determined by psychometric tests, can accurately predict the development of overt HE after TIPS. Patients will be studied before TIPS and followed after TIPS for the development of overt HE. The role of sarcopenia in favoring HE, as well as is possible reversibility after TIPS will also be investigated.
The present invention relates to compositions and methods using an isolated chimeric molecule, wherein the isolated chimeric molecule comprises an antibody, one or more albumin motifs, optional peptide linkers, and two or more antibiotics or cytotoxic drug molecules conjugated to the unpaired cysteine residues, optionally through linkers. In one embodiment, each of the said albumin motifs in the isolated chimeric molecule contains 2 or more unpaired cysteine residues. In another embodiment, the said antibody in the isolated chimeric molecule targets antigens on cancer cells or drug-resistant bacteria. In another embodiment, the cancer cells have upregulated macropinocytosis. In another embodiment, the cancer cells contain one or more mutations in their RAS family genes. The compositions of the invention are used to treat drug-resistant bacterial infections and cancers, preferably the ones with upregulated macropinocytosis, and the ones containing one or more mutations in their RAS family genes.