anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Blood will be drawn from the patient using the Pure PRP II system into a syringe with anticoagulant (sodium citrate). 1 mL of blood will be separated and sent to a lab for analysis. Remaining blood will be separated into a single concentrating device and centrifuged to separate red blood cells from plasma and platelets. The plasma and platelets will be separated off with a syringe and re-centrifuged to separate the platelets from the plasma. 1 mL will be separated and sent to a lab for analysis leaving 6 mL for injection. Both the 1 mL of blood and the 1 mL of PRP will be sent to an independent lab to undergo analysis for CBC, TNC, human CD34+ hematopoietic stem/progenitor cell assay and CFU-F. Physician will then inject the PRP into the affected knee joint.
In a recent study on animal model (results not yet published), the use of drop deposition combined to Raman spectroscopy provided for the first time the Raman spectral signature of healthy SF. Tribological analysis of simple dried drops of SF showed the potentiality to observe physical and chemical changes due to OA process. HA concentration was correlated with the dried drop area and the increase of protein content was correlated with the height of the peripheral rim. Spectral acquisitions detailed/specified these observations as degradation of cartilage and bone tissues was measured using specific Raman band ratios. These results suggested that DDRS could be an innovative tool in OA clinical research. In this context, the Sponsor would like to assess the clinical pertinence of this innovative analytical tool in a PoC study using OA patients receiving IA injection of SYNVISC ONE®.
IL-1β is an important cytokine implicated in the progression of inflammatory bowel disease (IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses bioactive properties, such as antitumor, antioxidant, anti-inflammatory, antihypertensive, and antiviral activities; however, its IL-1β-targeted anticolitis activity remains unclear. Here, we evaluated the inhibitory effect of geraniin in IL-1β-stimulated Caco-2 cells and a dextran sulfate sodium (DSS)-induced colitis mouse model. Geraniin blocked the interaction between IL-1β and IL-1R by directly binding to IL-1β and inhibited the IL-1β activity. It suppressed IL-1β-induced intestinal tight junction damage in human Caco-2 cells by inhibiting IL-1β-mediated MAPK, NF-kB, and MLC activation. Moreover, geraniin administration effectively reduced colitis symptoms and attenuated intestinal barrier injury in mice by suppressing elevated intestinal permeability and restoring tight junction protein expression through the inhibition of MAPK, NF-kB, and MLC activation. Thus, geraniin exhibits anti-IL-1β activity and anticolitis effect by hindering the IL-1β and IL-1R interaction and may be a promising therapeutic anti-IL-1β agent for IBD treatment.
Use of letrozole tablets may cause decreases in bone mineral density (BMD). Consideration should be given to monitoring BMD. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2-L4) bone mineral density (BMD) of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median decrease in lumbar spine BMD of 4.1% in the letrozole arm compared to a median increase of 0.3% in the tamoxifen arm (difference = 4.4%) (P<0.0001) [see Adverse reactions (6)]. Updated results from the BMD substudy (MA-17B) in the extended adjuvant setting demonstrated that at 2 years patients receiving letrozole had a median decrease from baseline of 3.8% in hip BMD compared to a median decrease of 2.0% in the placebo group. The changes from baseline in lumbar spine BMD in letrozole and placebo treated groups were not significantly different [see Adverse Reactions (6)].    
  
In the adjuvant trial (BIG 1-98) the incidence of bone fractures at any time after randomization was 14.7% for letrozole and 11.4% for tamoxifen at a median follow-up of 96 months. The incidence of osteoporosis was 5.1% for letrozole and 2.7% for tamoxifen [see Adverse Reactions (6)]. In the extended adjuvant trial (MA-17), the incidence of bone fractures at any time after randomization was 13.3% for letrozole and 7.8% for placebo at a median follow-up of 62 months. The incidence of new osteoporosis was 14.5% for letrozole and 7.8% for placebo [see Adverse Reactions (6)].
The invention discloses a preparation method of white gourd whitening and freckle removing facial cleansing paste. According to the technical formula, the white gourd whitening and freckle removing facial cleansing paste is prepared from, by mass, 4-7 parts of white gourd vine ash, 3-6 parts of white gourd flesh juice, 1-1.8 parts of white gourd seed powder, 1.2-2.5 parts of peach blossoms, 0.5-1.5 parts of bee milk and 1-1.8 parts of liquorice. The preparation method comprises the steps that the white gourd vine ash, the white gourd flesh juice, the white gourd seed powder, the peach blossoms, the bee milk and the liquorice are prepared according to the mass matching ratio, and are mixed and stirred to be uniform. The preparation method of the white gourd seed powder comprises the steps that fresh white gourd seeds are cleaned, dried in the sun, baked for 2-5 min at the temperature of 40-80 DEG C, taken out and peeled through a conventional method, per kg of white gourd seeds are soaked in 1-1.8 L of a concentrated salt solution at the temperature of 30-40 DEG C for 0.5-5 min, the white gourd seeds are taken out, subjected to heat treatment in the water at 100-120 DEG C, smashed to be in liquid state and sieved by a 300-mesh sieve, and finally the obtained liquid matter is dried through spraying. The preparation method of the white gourd vine ash comprises the steps that picked white gourd vines are cleaned and divided into long sections of the length of 20 cm, the long sections are dried in the sun or dried through fire and placed into a combustion furnace to combusted into ash, and the ash is porphyrized and sieved by a 40-60-mesh sieve. The white gourd flesh juice is obtained by removing seeds in fresh white gourd flesh, squeezing the fresh white gourd flesh and obtaining the juice. The peach blossoms and the liquorice are dried, porphyrized and sieved by the 40-60-mesh sieve.
BACKGROUND: Few studies have evaluated the association between asymptomatic cholesterol emboli on fundoscopy (known as Hollenhorst plaque) and the subsequent risk of stroke or death.1.
AIM: To evaluate the association between the presence of asymptomatic cholesterol retinal emboli and the risk of cerebrovascular events, with assessment of the need for carotid intervention.
METHODS: PubMed, Embase, and Cochrane Library databases were searched using appropriate terms. The systematic review was conducted according to PRISMA guidelines.
RESULTS: Initial search revealed 43 in Medline and 46 in Embase databases. Twenty-four potentially eligible studies were included after duplicate and non-related studies were excluded based on title and abstract. Three more studies were identified from reference lists. Seventeen studies were included in the final analysis. Asymptomatic cholesterol emboli were present in 1343 patients. Approximately 17.8% (n = 181) had history of either cerebro-vascular Accident (CVA) or transient ischaemic attacks (TIAs) at presentation (more than 6 months). Nine studies mentioned the incidence of cerebrovascular events during follow-up. Of 780 patients, 93 evolved to stroke, TIAs, or death from a major carotid event during the follow-up period (6-86 m), an incidence of about 12%. Death due to stroke was documented in 3 studies (n = 12).
CONCLUSION: The presence of asymptomatic retinal emboli indicates a risk of a cerebrovascular event when compared to patients with no plaques seen on fundoscopy. The evidence suggests that these patients warrant referral for medical optimization of cardiovascular risk factors. Currently, there is no recommendation to support carotid endarterectomy in patients with Hollenhorst plaques, or retinal emboli, and further studies are needed to assess this.
PURPOSE:To obtain a food of making person regularly and naturally have a motion and feel like going to stool, maintaining a proper movement and intestinal action after dissolution of constipation by adding fructooligosaccharide to powder of Lentinus edodes. CONSTITUTION:Powder of Lentinus edodes is blended or combined with fructooligosaccharide to give a health-directed food. The blending ratio of fructooligosaccharide to powder of Lentinus edodes in the food is preferably 10-50wt.% of the latter based on 90-50wt.% of the former, especially preferably 15-30wt.% of the latter based on 85-70wt.% of the former. Powder of Lentinus edodes has low bulk specific gravity, high bulkiness and is readily scattered. On the other hand, when fructooligosaccharide is used in a state of powder, fructooligosaccharide has extremely strong water vapor absorption, absorbs water and becomes tacky even in allowing stand in air for a short time and is inconvenient for handling and eating. But these defects can be conquered by blending fructooligosaccharide with powder of Lentinus edodes and a mixture reducing the volume of powder of Lentinus edodes and suppressing scattering thereof can be obtained.
5 Disclosed herein are methods of modulating gastrointestinal gene expression. In one example, the disclosed method includes administering a composition comprising 0 1,3 (4)-endoglucanohydrolase, 3-1,3 (4)glucan, diatomaceous earth, mineral clay, and glucomannan under conditions sufficient to modulate one or more gastrointestinal genes in a human or animal species. The compositions can be fed to any mammalian or avian 10 species including, but not limited to, bovine, equine, ovine, caprine and avian species. When admixed with the feed or food or fed as a supplement, the composition can be used to regulate (e.g., up-regulate or down-regulate) one or more gastrointestinal genes, such as to induce or enhance energy metabolism genes, nutrient transport genes, or a combination thereof. The disclosed methods can also be used to regulate, such as 15 enhance or induce Type I and/or Type II antigen presentation and in turn inducement or enhancement of an immune response. 2619290_1 (GHMatters)
Chloroquine-based medicaments wihtout a bitter taste contain a complex of chloroquine (I) with a methacrylic acid/methyl methacrylate copolymer (II) having a molecular wt. of 130,000-150,000 and an acid:ester ratio of ca. 1:1. USE/ADVANTAGE - The compsns. are useful for prophylaxis of malaria. The complexes have the same activity as known chloroquine derivs. but have no bitter taste and have good storage stability.
Families who call the healthline service about a sick child (no danger signs) and live outside the delivery area will receive illness assessments and treatment recommendations over the phone. Illness progression will be tracked with a 8-12 day follow up call.
Orally administered cholic acid is subject to the same metabolic pathway as endogenous cholic acid.

Cholic acid is absorbed by passive diffusion along the length of the gastrointestinal tract. Once absorbed, cholic acid enters into the body's bile acid pool and undergoes enterohepatic circulation mainly in conjugated forms.

In the liver, cholic acid is conjugated with glycine or taurine by bile acid-CoA synthetase and bile acid-CoA:amino acid N-acetyltransferase. Conjugated cholic acid is actively secreted into bile by the BSEP, and then released into the small intestines, along with other components of bile.

Conjugated cholic acid is mostly re-absorbed in the ileum mainly by the apical-sodium-dependent-bile acid transporter, passed back to the liver by transporters including sodium-taurocholate cotransporting polypeptide and organic anion transport protein and enters another cycle of enterohepatic circulation. Any conjugated cholic acid not absorbed in the ileum passes into the colon where deconjugation and 7-dehydroxylation are mediated by bacteria to form cholic acid and deoxycholic acid, which may be re-absorbed in the colon or excreted in the feces. The loss of cholic acid is compensated by de-novo synthesis of cholic acids from cholesterol to maintain the bile acid pool in healthy subjects.
FIELD: biotechnology. SUBSTANCE: new strain of trichophyton mentagrophytes No. 27 is produced which offers high level of sporogenesis, population homogeneity, decreased residual virulence to increase immunogenic activity of preparation against animal trichphytosis. Offered strain is deposited in collection of microorganism of the VGNKL research institute of veterinary preparation under No 27. EFFECT: vaccine prepared from offered strain ensures stable strong immunity after 20-30 days after application for cattle, sheep, goats and rabbits; immunity duration is not less than 5 years. 2 tbl
BACKGROUND AND AIMS: Epigenetic plasticity is a major challenge in cancer-targeted therapy. However, the molecular basis governing this process has not yet been clearly defined. Despite the considerable success of poly(ADP-ribose) polymerase inhibitors (PARPi) in cancer therapy, the limited response to PARPi, especially in HCC, has been a bottleneck in its clinical implications. Herein, we investigated the molecular basis of the histone methyltransferase KMT5C (lysine methyltransferase 5C) that governs PARPi sensitivity and explored a potential therapeutic strategy for enhancing PARPi efficacy.
APPROACH AND RESULTS: We identified KMT5C, a trimethyltransferase of H4K20, as a targetable epigenetic factor that promoted liver tumor growth in mouse de novo MYC/Trp53-/- and xenograft liver tumor models. Notably, induction of KMT5C by environmental stress was crucial for DNA repair and HCC cell survival. Mechanistically, KMT5C interacted with the pivotal component of homologous recombination repair, RAD51, and promoted RAD51/RAD54 complex formation, which was essential for the activation of dsDNA breaks repair. This effect depended on the methyltransferase activity of KMT5C. We further demonstrated that the function of KMT5C in promoting HCC progression was dependent on RAD51. Importantly, either a pharmacological inhibitor (A196) or genetic inhibition of KMT5C sensitized liver cancer cells to PARPi.
CONCLUSIONS: KMT5C played a vital role in promoting liver cancer progression by activating the DNA repair response. Our results revealed a novel therapeutic approach using the KMT5C inhibitor A196, concurrent with olaparib, as a potential HCC therapy.
The invention concerns the application of starch propionate as a feed additive and/or ingredient to feed to aquaculture and agricultural animals. It promotes growth and/or obtains a faster weight gainand/or better feed utilization and/or improved meat percentage. Starch propionate functions as a platform for the liberation of propanoic acid in the lower gastrointestinal tract where fermentation of dietary fibers takes place. It passes undigested through the upper part of the gastrointestinal tract.In the colon / lower intestinal tract, propanoic acid is liberated and enhances the concentration of propanoic acid. Propanoic acid stimulates the intestinal wall and promotes the development of the gastrointestinal tract to increase villi length, increase the surface area and increase the cell density. By this more nutrients can be absorbed. In aquaculture and agricultural animals, a healthier gastrointestinal tract will promote growth, and lower the need for antibiotics and medicinal zinc.
A curariform drug is obtained by finely dividing freshly selected plants of the group: Araceae, Minispermaceae, Anonaneae, Loganiaceae, Proteaceae and Rubiaceae, while retaining all the juices in the mass, treating the mass with hot water to extract the solvent material therein, removing undissolved solids from the liquid solution, e.g. by evaporating the liquid to a viscous concentrate and dessicating the concentrate and grinding the resultant to a fine powder.  The alkaloidal content may be removed from the resultant powder and the extract dissolved in water.ALSO:A curariform drug is obtained by finely dividing freshly selected plants of the group: Araceae, Minispermaceae, Anonaneae, Loganiaceae, Proteacea and Rubiaceae while retaining all the juices in the mass, treating the mass with hot water to extract the solvent material therein, removing the undissolved solids from the liquid solution, e.g. by evaporating the liquid to a viscous concentrate and desiccating the concentrate, and grinding the resultant to a fine powder.  The alkaloidal content may be removed from the resultant powder and the extract dissolved in water.  There may be added also to the alkaloidal extract, venom from Paraponera clavata Fabr.  Sodium chloride and trichlorobutanol may be added to the final product as preservatives and the pH value may be adjusted.
BACKGROUND: Despite the established knowledge that recurrent copy number variants (CNVs) at the 16p11.2 locus BP4-BP5 confer risk for behavioural and language difficulties, limited research has been conducted on the association between behavioural and social-communicative profiles. The current study aims to further delineate the prevalence, nature and severity of, and the association between, behavioural and social-communicative features of school-aged children with 16p11.2 deletion syndrome (16p11.2DS) and 16p11.2 duplication (16p11.2Dup).
METHODS: A total of 68 individuals (n = 47 16p11.2DS and n = 21 16p11.2Dup) aged 6-17 years participated. Standardised intelligence tests were administered, and behavioural and social-communicative skills were assessed by standardised questionnaires. Scores of both groups were compared with population norms and across CNVs. The influence of confounding factors was investigated, and correlation analyses were performed.
RESULTS: Compared with the normative sample, children with 16p11.2DS showed high rates of social responsiveness (67%) and communicative problems (69%), while approximately half (52%) of the patients displayed behavioural problems. Children with 16p11.2Dup demonstrated even higher rates of social-communicative problems (80-90%) with statistically significantly more externalising and overall behavioural challenges (89%). In both CNV groups, there was a strong positive correlation between behavioural and social-communicative skills.
CONCLUSIONS: School-aged children with 16p11.2 CNVs show high rates of behavioural, social responsiveness and communicative problems compared with the normative sample. These findings point to the high prevalence of autistic traits and diagnoses in these CNV populations. Moreover, there is a high comorbidity between behavioural and social-communicative problems. Patients with difficulties in both domains are vulnerable and need closer clinical follow-up and care.
The invention belongs to the technical field of gene tumor treatment, and particularly relates to an application of CHMP1B gene serving as a target in screening tumor treatment medicines and the tumor treatment medicines thereof. The invention provides a basis for CHMP1B gene as a potential target point for lung cancer treatment. The detailed sequence and related information about the CHMP1B gene are shown below. The main research method of the invention is to knock down CHMP1B gene of lung cancer cell line by shRNA to reduce the expression of CHMP1B in lung cancer, and then select out the cell with CHMP1B gene knock down effect. In vitro cytology experiments and in vivo animal experiments are carried out by using the screened cells, and the proliferation, migration, invasion and growth of tumor cells are effectively inhibited. Therefore, CHMP1B is considered to be a target gene for anti-tumor treatment in lung cancer, and the therapeutic effect is achieved by knocking down the expression of the CHMP1B, and reference is provided for other tumor treatment.
Experimental and clinical studies have clearly demonstrated significant sex differences in myocardial structure and function, both under physiological and pathological conditions. The best example are significant sex differences in the cardiac tolerance to ischemia/reperfusion injury: pre-menopausal adult female hearts are more resistant as compared to the male myocardium. The importance of these findings is supported by the fact that the number of studies dealing with this issue increased significantly in recent years. Detailed molecular and cellular mechanisms responsible for sex differences are yet to be elucidated; however, it has been stressed that the differences cannot be explained only by the effect of estrogens. In recent years, a promising new hypothesis has been developed, suggesting that mitochondria may play a significant role in the sex differences in cardiac tolerance to oxygen deprivation. However, one is clear already today: sex differences are so important that they should be taken into consideration in the clinical practice for the selection of the optimal diagnostic and therapeutic strategy in the treatment of ischemic heart disease. The present review attempts to summarize the progress in cardiovascular research on sex-related differences in cardiac tolerance to oxygen deprivation during the last 40 years, i.e. from the first experimental observation. Particular attention was paid to the sex-related differences of the normal heart, sex-dependent tolerance to ischemia-reperfusion injury, the role of hormones and, finally, to the possible role of cardiac mitochondria in the mechanism of sex-dependent differences in cardiac tolerance to ischemia/reperfusion injury. Key words: Female heart, Cardiac hypoxic tolerance, Ischemia-reperfusion injury, Sex differences.
A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion forumulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
Protein quantitative trait loci (pQTLs) are an invaluable source of information for drug target development because they provide genetic evidence to support protein function, suggest relationships between cis- and trans-associated proteins, and link proteins to disease endpoints. Using Olink proteomics data for 1,463 proteins measured in over 54,000 samples of the UK Biobank, we identified 4,248 associations with 2,821 ratios between protein levels (rQTLs). rQTLs were 7.6-fold enriched in known protein-protein interactions, suggesting that their ratios reflect biological links between the implicated proteins. Conducting a GWAS on ratios increased the number of discovered genetic signals by 24.7%. The approach can identify novel loci of clinical relevance, support causal gene identification, and reveal complex networks of interacting proteins. Taken together, our study adds significant value to the genetic insights that can be derived from the UKB proteomics data and motivates the wider use of ratios in large-scale GWAS.