anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
ETHNOPHARMACOLOGICAL RELEVANCE: Angong Niuhuang Pill (ANP) is a traditional Chinese medicine formula that has been used clinically for many years in the treatment of cerebral hemorrhage. It is composed of ingredients such as calculus bovis, moschus, and others. Ancient texts have documented that ANP's multiple components possess properties such as heat-clearing, detoxification, and sedation, which can be effective in treating conditions such as coma and stroke. However, the underlying mechanisms of ANP's potential actions are still under investigation.
AIM OF THE STUDY: ANP is a Chinese medicine widely utilized for the treatment of intracerebral hemorrhage (ICH). However, the precise mechanism underlying the therapeutic effects remains largely elusive. The present study aims to unravel the effects and pharmacological molecular mechanisms of ANP in combatting ICH, employing a comprehensive network pharmacology approach and experimental validation.
MATERIALS AND METHODS: The molecular targets of ANP and ICH were obtained from various databases, followed by the construction of protein-protein interaction (PPI) networks using the STRING database. Further, gene ontology (GO) enrichment and Kyoto encyclopedia of genes and genomes (KEGG) analyses were conducted using the Metascape database and Cytoscape, respectively. Finally, molecular docking was performed. We performed a series of behavioral tests, immunohistochemical staining, TUNEL staining, and Western Blot to verify the effects of ANP.
RESULTS: IL-6, JUN, MMP9, IL-1β, VEGFA were the main candidate targets and were associated with fluid shear stress and atherosclerosis, TNF signaling pathway, etc. It is suggested that the potential mechanism of ANP against ICH may be mainly related to pyroptosis, inflammation. In vivo validation showed that ANP treatment significantly reduced the number of TUNEL-positive cells and ANP inhibited the activation of Iba-1 positive neurons, and suppressed the expression of inflammatory factors and pyroptosis indicators. In addition, ANP improved the cognitive level and motor ability of ICH mice.
CONCLUSION: The results of the study combined with virtual screening and experimental validation showed that ANP has an important contribution in protecting the brain from neuronal damage by regulating the pathways of inflammation and pyroptosis, laying the foundation and innovative ideas for future studies.
FIELD: biotechnology. SUBSTANCE: method involves homogenization of animal embryo muscle tissues, then homogeneity is kept for 10-20 h followed by extraction and precipitate is removed. Obtained solution is diluted additionally with physiological solution up to protein concentration in it 15-25 mg/ml, preserving agent is added and formed suspension is separated. Then solution is kept for 48 h, sterilized, thermostated, kept at 15 C, not above, for 30-40 days, formed suspension is removed and solution is subjected for interaction with immobilized proteolytic enzyme. Invention can be used in medicine and pharmacology. An agent exhibits high effectiveness in treatment of patients with sicknesses associated with damage of cell differentiation. EFFECT: enhanced efficiency. 1 dwg, 1 ex
Participants randomized to treatment as usual will receive treatment from study clinicians who do not have access to the participant's report for the first 12 weeks. At Visit 5, Week 12, participants will receive a copy of their pharmacogenetics report and clinicians will be unblinded to be able to use the results to guide treatment options for an additional 12 weeks.
Patients participate in the cancer pain rehabilitation program for 6 weeks, including educational sessions over 2 hours once weekly, group psychological interventions, group physical therapy, and 1:1 physical and occupational therapy treatment per the patient's treatment plan. Patients may also undergo osteopathic manual treatments per physical and occupational therapy assessments.
Under total sleep deprivation, both inhibitory and motor control are impaired. However, how circadian rhythm sleep loss caused by irregular sleep pattern affects motor inhibition and execution in continuous actions remains unknown. This study utilized a pointing task to investigate the question over 30 days. During regular trials, participants were instructed to tap on a specified location, while in countermanding trials, they were required to countermand their current action. Additionally, there was a control group performed the same task following a normal 24-h rhythm. The results indicated that the decrease in accuracy and the increase in movement time in countermanding trials were more prominent in the shift work group. In contrast, there was no significant difference in reaction time between the two groups. Notably, the shift work group outperformed the control group in terms of movement time in regular trials and radial displacement in countermanding trials. Overall, these results show that circadian rhythm sleep loss predominantly affects inhibitory control, rather than motor control, underscoring the nuanced impacts of sleep disruption on differential aspects of cognitive and motor functions.
The invention relates to a medical equipment networking system and a medical equipment networking method. The medical equipment networking system at least comprises: the management center and the plurality of protection terminals are provided with IP-free firewalls, and the protection terminals are in signal connection with the management center. The protection terminal is connected with the medical equipment to be networked, so that data received or transmitted by the medical equipment pass through the protection terminal. The management center sends a first data stream containing identity authentication information to the medical equipment, the protection terminal performs identification processing on the first data stream, and the medical equipment performs networking through the protection terminal under the condition that the protection terminal confirms that the identity authentication information accords with a preset rule. According to the invention, the protection terminal with the IP-free firewall is used for protecting the medical equipment to be networked, so that the network attack behavior based on the IP address can be resisted, and the unknown security threat can be safely and effectively prevented. In a complex and changeable network environment, the data flow can be accurately and quickly identified, and quick and safe deployment and networking of medical equipment are realized.
Subjects with Sarcoidosis associated calcium dysregulation will be administered 80 units of Acthar Gel (adrenocorticotropic hormone) twice a week for 12 weeks. Clinical visits will be scheduled for -30 days, day of 1st dose and 4,8,12 and 16 week after 1st dose to monitor the health of subjects.
The invention discloses composite gel for plant capsules and a preparation method for the composite gel. The composite gel is prepared by fully and evenly mixing raw materials in a mixing machine, wherein the raw materials comprise 1-15 parts of K-carrageenan, 0.5-7.5 parts of iota-carrageenan and 77.5-98.5 parts of component C (cellulose derivative and/or plant polysaccharide) in parts by weight. The composite gel for the plant capsules is proper in raw material ratio and can be suitable for producing various plant capsules, thus, the percent of pass of plant capsule products is greatly increased. Through controlling the viscosity and the temperature stability of the gel, the empty plant capsules meeting the standard of China pharmacopoeia are prepared. The waterproof rate and oxygen-proof rate of the capsules are improved and the waterproof effect and the oxygen-proof effect of the capsules are enhanced, thus, the content can be stabilized and the quality guarantee periods of the products can be prolonged. Meanwhile, the problems that the raw materials for producing the plant capsules are various, the operation is complicated and the quality standard is not stable and cannot be controlled are solved.
The invention discloses a horn-removing paste and a preparation method and a use method thereof. The fillet removing paste consists of 1000-1200 parts of deionized water, 370-390 parts of sodium hydroxide powder, 830-850 parts of calcium hydroxide powder and 330-350 parts of glycerol. The preparation method of the fillet removing paste obtains a product with better quality by restricting the material mixing sequence, the material mixing speed and the material mixing temperature. The application method of the fillet removing ointment controls the usage amount and the drug effect area of the fillet removing ointment by designing and using a specific ointment packaging structure, and can effectively prevent the fillet removing ointment from corroding the surrounding tissues of the ox horn while being convenient for a user to operate. The horn-removing paste has proper dispersibility, viscosity and humidity, is not easy to flow, and contains an astringent which can effectively reduce exudation of tissue fluid, effectively avoid excessive corrosion of alkaline components of the horn-removing paste to tissues around horns of calves, and avoid triggering stress reaction. The use method of the fillet removing paste designed by the invention can further prevent the alkali liquor from overflowing and being excessively corroded.
To our knowledge, this is the first report of anterior segment ischaemia after PreserFlo Micro-Shunt insertion surgery. Our patient developed anterior chamber (AC) activity and keratic precipitates 1 week after surgery. Five weeks after surgery, examination revealed a shallow AC, a distorted pupil with posterior synechiae and surface iris neovascularisation. Ocular ischaemic syndrome was excluded after performing fundus fluorescein angiography and carotid Doppler ultrasound. The patient responded well to frequent topical steroids and atropine eye drops. 10 weeks postoperatively, the iris neovascularisation had completely regressed with a deep and quiet AC and diffuse filtering bleb with an intraocular pressure of 10 mm Hg without using any pressure-lowering drops. Proposed steps to minimise future incidence of anterior segment ischaemia include avoidance of peri-limbal cautery, controlled use of mitomycin-C application and avoidance of extensive superior fornix dissection.
This intervention will consist of an initial 10 minutes of rest, followed by 90 minutes of aerobic activity and 60 minutes of the final recovery. In this protocol, volunteers will be hydrated with mineral water from the 15th minute of exercise until the end of recovery.
Syphilis is a sexually transmitted infection, caused by the spirochete Treponema pallidum, that can lead to multi-organ involvement. In 2020, over 138,000 cases were reported in the United States equating to a case report of 40.8 per 100,000 people. Ocular syphilis is a rare manifestation and is defined as the clinical presentation of ocular disease in a person with laboratory-confirmed syphilis infection of any stage, with estimated incidence of 0.6-2% of all cases. Syphilis is known as "The Great Imitator," and can present as nearly any form of ocular disease, though the most common manifestations are posterior uveitis and panuveitis. The highly variable clinical presentation of ocular syphilis often leads to delayed diagnosis allowing the potential for poor, often preventable outcomes. This highlights the need for providers to have a high level of clinical suspicion and awareness of ocular manifestations of syphilis, especially in high risk populations. We present a case series of five patients diagnosed with ocular syphilis at a military treatment facility. Each patient had different presenting symptoms as well as different ocular manifestations.
Forty seven patients are critically ill without evidence of infectious organism (SIRS group). At admission, Patients data include clinical status; SOFA score; central venous pressure; laboratory analysis and arterial blood gas analysis are measured. Routine cultures will be obtained. The attending physician will evaluate the patients for sepsis, severe sepsis, or septic shock as long as their stay in ICU. A serum level of CD 14 and CD88 will be monitored.
Healthcare professionals have first-hand experience with patients in clinical practice and the dynamics in the healthcare system, which can be of great value in the design, implementation, data analysis and dissemination of research study results. Primary care professionals are particularly important as they provide first contact, accessible, coordinated, comprehensive and continuous people-focused care. However, in-depth examination of the engagement of health professionals in health system research and planning activities-how professionals are engaged and how this varies across national contexts- is limited, particularly in international initiatives. There is a need to identify gaps in the planning of engagement activities to inform the design and successful implementation of future international efforts to improve the responsiveness of health systems to the changing needs of patients and professionals. The aim of this study was to explore how primary care professionals were engaged in the design and implementation plans of an international health policy study led by the Organisation for Economic Co-operation and Development (OECD). The OECD's international PaRIS survey measures and disseminates information on patient-reported outcome and experience measures (PROMs and PREMs) of people living with chronic conditions who are managed in primary care. A documentary analysis of 17 written national implementation plans (country roadmaps) was conducted between January and June 2023. Two reviewers independently performed the screening and data abstraction and resolved disagreements by discussion. We reported the intended target primary care professionals, phase of the study, channel of engagement, level of engagement, and purpose of engagement. All 17 countries aimed to engage primary care professionals in the execution plans for the international PaRIS survey. While organisations of primary care professionals, particularly of family doctors, were the most commonly targeted group, variation was found in the timing of engagement activities during the different phases of the study and in the level of engagement, ranging from co-development (half of the countries co-developed the survey together with primary care professionals) to one-off consultations with whom. International guidance facilitated the participation of primary care professionals. Continuous collaborative efforts at the international and national levels can foster a culture of engagement with primary care organisations and individual professionals and enhance meaningful engagement of primary care professionals.
The adoption of information and communication technology (ICT) by older adults with cognitive frailty and impairment is beneficial to support aging in place and promote healthy aging. However, data are scarce regarding the use of ICT by this demographic in comparison with other age groups. This bibliometric analysis was aimed at systematically mapping the literature on ICT-related research on older adults with cognitive frailty and cognitive impairment to provide insights into research trends, patterns and knowledge gaps. Data were extracted from the Web of Science database, which identified 324 publications between 1980 and 2023. Performance analysis and science mapping were carried out using Microsoft® Excel, VOSViewer and Harzing's Publish or Perish. The analysis showed an upsurge in the research output trend over time. Notable journals, authors, citations, nations and research areas have been documented. Four key clusters were identified, including: (i) caregiver concern, support and involvement; (ii) technology as a tool for cognitive training and cognitive rehabilitation; (iii) cognitive improvement; and (iv) the use of technology for prevention and self-management. The findings derived from this analysis provide an appropriate reference for future researchers to bridge the gap in ICT-related studies among this population, and distinguish the relevant articles that are required for further investigation. These include the need for further long-term research, the incorporation of ICT-based approaches to counter cognitive frailty and the importance of multidomain telehealth interventions. Geriatr Gerontol Int 2024; 24: 251-262.
Mandatory thrice a week (Mondays, Wednesdays, and Fridays) treatment with SC ACTH gel 80 U/day starting at BL until month 6. Starting at month 6, the treatment will be administered on as needed basis, based on the retreatment criteria.
Patients receive gemcitabine hydrochloride IV on days 1, 8, and 15. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.
Participants who have had progression or recurrence of UC following a platinum-containing regimen in the metastatic setting, or progression or recurrence of UC within 12 months of completion of platinum-based therapy as neoadjuvant or adjuvant therapy will receive SG 10 mg/kg intravenously on Days 1 and 8 of a 21-day cycle and pembrolizumab at the standard approved dose (200 mg) only on Day 1 of a 21-day cycle. Lower doses of SG may be tested based on dose-limiting toxicities (DLTs) observed to determine the Recommended Phase 2 Dose (RP2D) of SG in combination with pembrolizumab.
As a research hotspot in the field of molecular biology, N6-methyladenosine (m6A) modification has made progress in the treatment of colorectal cancer (CRC), leukemia and other cancers. Numerous studies have demonstrated that the tumour microenvironment (TME) regulates the level of m6A modification in the host and activates a series of complex epigenetic signalling pathways through interactions with CRC cells, thus affecting the progression and prognosis of CRC. However, with the diversity in the composition of TME factors, this action is reciprocal and complex. Encouragingly, some studies have experimentally revealed that the intestinal flora can alter CRC cell proliferation by directly acting on m6A and thereby altering CRC cell proliferation. This review summarizes the data, supporting the idea that the intestinal flora can influence host m6A levels through pathways such as methyl donor metabolism and thus affect the progression of CRC. We also review the role of m6A modification in the diagnosis, treatment, and prognostic assessment of CRC and discuss the current status, limitations, and potential clinical value of m6A modification in this field. We propose that additional in-depth research on m6A alterations in CRC patients and their TME-related targeted therapeutic issues will lead to better therapeutic outcomes for CRC patients.
Heart failure with preserved ejection fraction (HFpEF) is common and is associated with high morbidity and mor-tality in China. Studies have shown that traditional Chinese medicine (TCM) combined with conventional Western medicine has a good effect on improving exercise tolerance and quality of life in patients with HFpEF, but there are still some shortcomings that limit the reliability and extrapolation of results. Based on TCM theory and our decades of experience, we developed Qishen Granules for therapeutic use in the treatment of HFpEF. The good effect of Qishen Granules in patients with heart failure has been clinically verified before. In this study, cardiopulmonary exercise test (CPET) was used to evaluate the peak oxygen consumption (peak VO2), which is the gold standard assessment of aerobic capacity. Therefore, we selected VO2 peak as the primary outcome. At the same time, we conducted a preliminary assessment of the efficacy of Qishen Granules in improving the quality of life in patients with HFpEF, using Kansas City Cardiomyopathy Questionnaire (KCCQ) as the secondary outcome, and combined with other CPET indicators, echocardiographic measures, NT-pro BNP level, growth STimulation expressed gene 2 (ST2), biomarkers of liver and kidney function, and TCM Four-Dimensional Diagnostic Information Scale (TCMFDIS) to objectively, accurately, and comprehensively evaluate the efficacy and safety of Qishen Granules in improving quality of life and exercise capacity in patients with HFpEF.
A light-duty liquid detergent composition consists of or comprises an essential mixture of non-soap surface-active agents, said mixture comprising from 10 to 95% by weight thereof of a component (A) consisting of water-soluble surface-active sulphate esters of the formula Z(OC2H4)mOSO3M; and from 5 to 90% by weight thereof of a component (B) consisting of surface active betaines of the formula <FORM:1084739/C4-C5/1> where, in each of said formulae, A represents an alkyl or alkenyl group having from 8 to 18 carbon atoms, Z is a group of Formula A or is an alkyl phenyl group possessing an alkyl substituent having from 6 to 16 carbon atoms, M is a cation, m has a value of from 0 to 20 (but is at least 1 when Z is an alkyl phenyl group), R1 and R2 are each methyl, ethyl, hydroxyethyl or hydroxypropyl, and B is an anionic group of the formula-(CH2)2CO-2 or -(CH2)zOSO-3 (wherein z has a value of 1, 2 or 3).  In the component (A) the cation M may be sodium, potassium, magnesium, ammonium, lithium, monoethanol ammonium, or triethanol ammonium.  The group Z may be lauryl, cetyl, oleyl, stearyl, lauryl - trioxyethylene, cetyl - dioxyethylene, p - octyl - phenyl - tetraoxyethylene or p-nonylphenyl-trioxyethylene. The group A in the component (B) may be lauryl, cetyl, stearyl or oleyl.  The composition may also contain foam stabilizers of which many examples are given, and other surface active agents such as alkyl benzene sulphonate salts, sulphosuccinate salts, tauride compounds, alkyl polyoxyethylene ethanols or alkyl phenyl polyoxy ethylene ethanols.  Medicaments such as hexachlorophene or 2,2,4 - trichlorocarbanalide and opacifying agents such as ethylene or propylene glycol monostearate may also be included. The compositions may be dissolved in water or in aqueous alcohol or may be thickened for example by a soap.  They may also contain inorganic sulphate impurities.  Examples are given of compositions suitable as dish-washers and as shampoos.
A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.