anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The outcome of peripheral nerve injury is related to age, level of injury, the injured nerve, the severity of injury, and the timing and the type of surgery interventions. In addition, high-level peripheral nerve injury would not full recovery, and the prognosis is determined by the nerve regeneration.

Conventional physical therapy includes electrical stimulation for denervated muscles, and soft tissue massage, joint range of motion exercises to maintain the flexibility of the affected joint, muscle or connected tissues. However, the nerve regeneration takes several months in high-level median, ulnar or radial nerve injury. Prolonged median or ulnar nerves injury may interfere intrinsic muscular function, and radial nerve injury causes drop hand. Earlier nerve regeneration or motor training is essential for the patients to return to normal life and increase their quality of life. This research aims to explore the effects of mirror therapy for peripheral nerve injury. We will enroll 60 patients who suffer from median, ulnar or radial nerve injury at the level of elbow or proximal forearm. The subjects will be randomized into the mirror-therapy group or the control group. Each group will receive conventional physical therapy (i.e., electrical stimulation, joint range of motion exercise, muscle strengthening training, sensory reeducation training). The mirror-therapy group would be supplemented by motor learning by mirror therapy. The measurements include joint range of motion, pain status, sensibility, grip strength, pinch strength, hand function test and the Disabilities of the Arm, Shoulder and Hand (DASH). Demographic information will be collected and analyzed by the independent t-tests. The outcome variables taken during the three and six months after the interventions would be included. One-way ANOVA are used to compare the difference between measurements. This study may offer an evidence based results to explore the effects of mirror therapy for peripheral nerve regeneration and motor learning.
During 1st treatment period subjects will receive iloperidone. During 2nd treatment period subjects will receive placebo.
Background Although care pathways are often said to promote teamwork, high-level evidence that supports this statement is lacking. The objective of the European Quality of Care Pathway (EQCP) study is therefore to study the impact of care pathways on interprofessional teamwork.

Methods/design An international post-test-only cluster Randomized Controlled Trial (cRCT), combined with process evaluations, will be performed in Belgium, Ireland, Italy and Portugal. Teams caring for Proximale Femur Fracture (PFF) patients and patients hospitalized with an exacerbation of Chronic Obstructive Pulmonary Disease (COPD) will be randomized into an intervention and control group. The intervention group will implement a care pathway for PFF or COPD containing three active components: a formative evaluation of the actual teams' performance, a set of evidence based key interventions and a training in pathway-development. The control group will provide usual care. As effect measures a set of team input, process and output indicators will be used. Main outcome indicator is the team process indicator relational coordination. Next to these, process measures will be used to evaluate the implementation process. In total, 132 teams agreed to participate, of which 68 were randomly assigned to the intervention group and 64 to the control group. Based on power analysis, a sample of 475 team members per arm is required. To analyze results, multilevel analysis will be performed.

Discussion The EQCP-study on teamwork is the first cluster-randomized controlled trial on the impact of care pathways on interprofessional teamwork. Results from our study will enhance understanding on the active components of care pathways. Through this, preferred implementation strategies can be defined.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely neurology, reflexotherapy. The method comprises the magnetic-laser therapy (MLT), acupuncture and therapeutic exercises (TE) with underlying pharmacotherapy. The MLT involves a paravertebral exposure at wave length 0.88 m, power 10 mW, magnetic field strength 40 mT, 4 minutes on each side alternately. The acupuncture represents another embodiment of the method of inhibition. At first, the acupuncture exposure is contralateral, and starting from the 3rd-5th procedure, the exposure also covers the involved side. All the exercises of each following session are conducted with rate load gain, an increase of the number and extent of the exercises. If observing paresis of the upper extremity, the MLT covers a collar region at the level of interosseus processes of the 5th-6th cervical and thoracic 1st-2nd vertebrae. At first, the acupuncture covers the point (TA) Lan-wei at a healthy ankle of the lower extremity. Starting from the 3rd-5th procedure, the exposure also involves the point Er-jian at a hand of the affected upper extremity. If observing paresis of the lower extremity, the MLT involves the lumbar-sacral region at the level of interosseus processes of the 2nd-3rd lumbar and 1st-2nd sacral vertebrae. Originally, the exposure covers the point Shou-san-li in a forearm of the healthy upper extremity. Starting from the 3rd-5th procedure, another version of the method of excitation is included on the affected side whereat the acupuncture needle is inserted into the point Tsu-syui within a foot of the affected lower extremity. If observing hemiparesis, the MLT includes the collar region at interosseus processes of the 5-6th cervical and 1rd-2nd thoracic vertebrae, then on the lumbosacral region. The exposure includes the point Lan-wei at the healthy ankle of the lower extremity and simultaneously the point Shou-san-li in the forearm of the healthy upper extremity. Starting from the 3rd-5th procedure, the exposure is added with a simultaneous effect on the point Er-jian at the hand of the affected upper extremity and on the point Tsyu-syui at the foot of the affected lower extremity. The physical exercises are combined with the correction of the hand and foot positions. For the purpose of the correction, a trainer extends the fingers and positions them properly in a combination with active-passive flexion and extension of the ankle joint. Treating the locomotor disorders starts 1-7 days after the ischemic stroke has been verified. The therapeutic course consists of 12-15 daily procedures.EFFECT: method provides higher clinical effectiveness, reduces the length of staying in hospital and the disability rate in the patients.3 ex, 5 tbl
The invention discloses a traditional Chinese medicine formula for treating lubar intervertebral disc protrusion. The formula is characterized by comprising the following components by weight: 120g of raw radix astragali, 30g of radix angelicae sinensis, 30g of prepared rhizome of rehmannia, 30g of radix aconiti preparata, 30g of radix aconiti lateralis preparata, 30g of teata glycinis, 15g of herba ephedrae, 18g of herba asari cum radice, 45g of ramulus cinnamomi, 45g of radix paeoniae alba, 30g of radix saposhnikoviae, 150g of honey, 45g of fresh ginger, 21 jujubes, 30g of fructus lycii, 30g of semen cuscutae, 30g of fructus psoraleae, and 30g of herba epimedii. A method for preparing a traditional Chinese medicine is as follows: 2,500ML (7-8 bowls) of cold water is added and the decoction process is performed with slow fire for 3.5 hours to obtain 600ML (1.5 bowls) of a decoction. The decoction is taken after meal for three times each day. A treatment course is 7 days. The traditional Chinese medicine can be continuously taken for one to two treatment courses. The formula solves the problems of high risk, strong side effects and the like of an existing treatment mode, and is suitable to treat the lubar intervertebral disc protrusion.
The present application describes a ceDNA vector with linear and continuous structure for delivery and expression of transgenes. The ceDNA vector comprises an expression cassette flanking two ITR sequences, wherein the expression cassette encodes a transgene, e.g., selected from table 1, encoding a PFIC therapeutic protein (e.g., ATP8B1, ABCB11, ABCB4, or TJP 2). Some ceDNA vectors also contain cis-regulatory elements, including regulatory switches. Also provided herein are methods and cell lines for reliable gene expression of PFIC therapeutic proteins in vitro, ex vivo, and in vivo using the cenna vectors. Provided herein are methods and compositions comprising a cendna vector useful for expressing a PFIC therapeutic protein in a cell, tissue or subject, and methods of treating a disease with the cendna vector expressing a PFIC therapeutic protein. Such PFIC therapeutic proteins may be expressed for treating a subject with Progressive Familial Intrahepatic Cholestasis (PFIC).
FIELD: organic chemistry, biochemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of nitromethylthiobenzene of the general formula 1   where P means the radical (I)  , (II)   or (III)  . Invention describes methods of synthesis of these compounds and their using as medicinal agents. These compounds inhibit activity of enzyme aldosoreductase and can be used for treatment or prophylaxis of peripheral and autonomic neurological complications associated with diabetes, renal and ophthalmic damages, for example, cataract and retinopathy. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 20 cl, 1 tbl
Canine strongyloidosis by Strongyloides stercoralis is a parasitic disease emerging in Europe, which represents both a veterinary clinical issue and a public health challenge because of the zoonotic potential. The disease, not yet frequent in Europe, could induce severe clinical signs in dogs; thus, an early diagnosis and appropriate treatment are desirable. The aim of the present work is to retrospectively investigate the clinical and paraclinical findings in sick dogs naturally infected by S. stercoralis, with particular attention to ultrasound (US) changes at the gastrointestinal level. Twelve dogs were included in the study. The diagnosis was made by means of larval morphological identification on faecal samples and PCR. Most dogs presented with gastrointestinal signs; diarrhea and weight loss were the most common presenting complaint. Only one dog showed respiratory signs, associated to a parasitic cutaneous nodule. Hypoproteinaemia, anaemia, leucocytosis and an increase in alpha2-globulin fraction at serum protein electrophoresis were common (>50%) but not constant findings. The most reported US picture was a fluid-filled, distended, atonic small intestine mostly associated with altered wall layering, while the wall thickness commonly associated with chronic enteritis was only rarely reported. These changes, associated with other clinical and paraclinical alterations, could increase the suspicion of canine strongyloidosis and may direct clinicians to include strongyloidosis in the differential diagnosis of dogs with diarrhea. The histological examination at the intestinal level, available in five dogs, revealed the presence of parasites from the full-thickness biopsy, but not from the endoscopic biopsy. The critical points of diagnosis in clinical practice are also discussed.
In the case of severe (70 to 90dB loss) and profound (\>90dB loss) hearing loss, when conventional hearing aids no longer provide sufficient benefit, cochlear implantation remains the only possible solution for hearing rehabilitation. In implanted patients, a clear improvement in communication in silence is observed, but almost all patients have difficulty understanding speech in noisy environments. Cochlear implantation involves inserting an electrode holder into the cochlea during a surgical procedure under general anesthesia. The insertion of the electrode holder must be as minimally traumatic as possible in order to preserve the cochlear structures and avoid post-operative fibrosis that could impact the auditory outcomes.

The conventional method of this surgery is the manual insertion of the electrode holder. In recent years, robotic assistance, the RobOtol®, has been developed with the aim of avoiding the jerks of the surgeon's hand and improving the precision of the insertion. RobOtol® has had its CE marking since 2016 and is used in several hospitals in France and abroad.
Under general anesthesia, cystoscopy will be performed. A needle will be inserted into the detrusor muscle to a depth of approximately 2 mm. 0.5 mL of 10 mL of 0.9% preservative-free sodium chloride will be injected into 20 equally spaced sites into the posterior and lateral walls of the bladder, sparing the dome and the trigone.
Undifferentiated thyroid cancer is the most malignant tumor of the thyroid gland, with a median survival of only 3 months. Most undifferentiated cancers lose the chance of surgery when they are first diagnosed. The current study, Nexavar, is used only for dedifferentiated thyroid cancer and has not been applied to undifferentiated cancer. This study attempted to apply it to preoperative treatment of undifferentiated cancer to see if it would shrink the tumor and give the patient an opportunity for surgery.

We chose patients with recurrent or inoperable anaplastic thyroid cancer and used NEXAVAR for 1 month of neoadjuvant therapy. If tumor lesions begin to resolve, they continue neoadjuvant therapy until the end of the second month. The total duration of preoperative treatment is two months.at the end of the second month, a CT scan was performed to assess whether surgery could be performed. If surgery is possible, NEXAVAR will continue to perform adjuvant radiotherapy after the surgery.
Given the changes in the digestive tract post-bariatric surgery, adapting to a new pattern of eating behavior becomes crucial, with special attention to the specifics of chewing mechanics. This study aimed to investigate the association between self-perception of chewing, chewing behavior, and the presence of gastrointestinal symptoms in preoperative patients undergoing bariatric surgery. Sixty adult candidates for bariatric surgery at a public hospital in Belém (Brazil) were analyzed. Participants predominantly exhibited unilateral chewing patterns (91.6%), a fast chewing rhythm (73.3%), a large food bolus (80%), liquid intake during meals (36.7%), and 41.7% reported that chewing could cause some issue. Significant associations were found between the perception of causing problems and chewing scarcity (p = 0.006), diarrhea (p = 0.004), absence of slow chewing (p = 0.048), and frequent cutting of food with front teeth (p = 0.034). These findings reveal a relationship between the perception of chewing problems and chewing scarcity, presence of diarrhea, and fast chewing.
A dentistry medicinal film consists of several layers. The first hydrophilic layer contains the active ingredient Metronidazol, the film-forming substances and the excipients. The second hydrophilic layer is attached to the first one through the adhesive interlayer. Oxypropylmethylcellulose and polyvinylpyrrolidone are used as the film-forming substances in the first layer. Glycerol, propylene glycol and water are used as the excipients. The second layer comprises Nimesulid, Oxypropylmethylcellulose, dimexide, glycerol, propylene glycol, and water.
OBJECTIVES: The modeled CA-125 elimination constant K (KELIM) is a pragmatic early marker of tumor chemosensitivity in ovarian cancer patients treated with neoadjuvant chemotherapy before interval surgery. The primary objective of this study was to assess the prognostic value of KELIM regarding the feasibility of complete surgery, and secondary objectives were to assess the prognostic value of KELIM for the risk of a platinum resistant relapse, progression free survival, and overall survival.
METHODS: The study was based on a retrospective cohort of 284 patients treated for an advanced serous high grade ovarian cancer, International Federation of Gynecology and Obstetrics (FIGO) stages III-IV, with neoadjuvant chemotherapy, followed by interval surgery, in a comprehensive cancer center. CA-125 concentrations at baseline and during neoadjuvant chemotherapy were collected. The KELIM predictive value regarding the tumor radiological response rate, likelihood of complete surgery, risk of subsequent platinum resistant relapse, progression free survival, and overall survival were assessed with univariate and multivariate tests.
RESULTS: In 232 patients, KELIM was an independent and major predictor of the probability of complete surgery and survival. The final logistic regression model, including KELIM (odds ratio (OR) 0.36, 95% confidence interval (CI)0.16 to 0.73, p=0.006) and complete surgery (no vs yes, OR 0.29, 95% CI 0.15 to 0.53, p<0.001), highlighted the complementary impact of chemosensitivity and surgical outcome relative to the complete surgery. In the multivariate analysis, KELIM and complete surgery were significantly associated with a lower risk of early relapse. In the case of an unfavorable KELIM, when surgical efforts allowed complete cytoreduction, median overall survival was similar to that reported in the case of a favorable KELIM (46.3 months (range 34.6-60.3) vs 46.5 months (range 40.6-68.7), respectively).
CONCLUSION: Primary tumor chemosensitivity, assessed by the modeled CA-125 KELIM, calculated during neoadjuvant chemotherapy, is a major parameter to consider for decision making regarding interval surgery. Complementary to the RECIST score and laparoscopy, this non-invasive tool, available online, helps tailor the interval surgery strategy according to patient tumor chemosensitivity.
The present invention provides a composition containing  beta -glucan in which the physiologically active effects of  beta -1,3-1,6-glucan contained in a cultured composition of a bacterium belonging to the genus Aureobasidium sp. are further enhanced, and a constipation-relieving drug, preparation an immunopotentiator, and a skin moistening agent using the composition. A composition containing  beta -glucan, which contains a cultured composition containing  beta -1,3-1,6-glucan obtained by culturing a bacterium belonging to the genus Aureobasidium sp. and lactic acid bacterium cells, is obtained. This composition containing  beta -glucan is employed as an active ingredient of a constipation-relieving drug, an immunopotentiator, or a skin moistening agent. Aureobasidium pullulans M-1 (FERM BP-08615) is preferable as the bacterium belonging to the genus Aureobasidium sp.. Moreover, Enterococcus faecalis is preferable as the lactic acid bacterium. It is still preferable that the lactic acid bacterium has been killed by heating. Furthermore, the content of the cultured composition in solid matters preferably ranges from 1 to 80% by mass in terms of  beta -1,3-1,6-glucan, while the content of the lactic acid bacterium cells preferably ranges from 4 to 95% by mass.
The present invention relates to a producing method of an injection for treating the dysentery of livestock and poultry. Series medicine in a rifomycin class is adopted as main medicine; antioxidants such as dimethylformamide, anhydrous alcohol, boracic acid, borax, disodium ethylene diamine tetraacetate, etc., and auxiliary materials such as surface active agents, preservative, etc., are added for refining into the injection. The injection has the advantages of simple producing processes, no three-waste pollution, low cost and easy use. The injection has a specific effect on various kinds of infectious dysentery, enteritis, diarrhea, etc. of livestock and poultry and has a good effect on the common infectious diseases or the parasitic disease of some livestock and poultry. The injection has the advantages of broad application range, high efficiency, rapid effects, small medicine dosage, no toxic or side effect, etc.
Paclitaxel administration using the OPC for the prevention of restenosis in infrainguinal de novo and restenotic femoropopliteal lesions. Subjects will be treated with the endovascular intervention selected by the treating physician in reference vessels ranging from 4mm to 7mm in diameter. Following the achievement of optimal interventional results (less than thirty (30) percent residual stenosis without stenting) the OPC will be placed at the interventional treatment area and paclitaxel will be delivered to the treated segment. Data will be collected to assess acute safety, long-term safety and durability to demonstrate the safety and efficacy of paclitaxel delivered with the ACT, Inc. OPC device.
FB_MR5 is a nucleotide-binding domain and leucine-rich repeat protein identified from wild apple species Malus × robusta 5 conferring disease resistance to bacterial fire blight. FB_MR5 (hereafter MrMR5) recognizes the cysteine protease effector EaAvrRpt2 secreted from the causal agent of bacterial fire blight, Erwinia amylovora. We previously reported that MrMR5 is activated by the C-terminal cleavage product (ACP3) of Malus domestica RIN4 (MdRIN4) produced by EaAvrRpt2-directed proteolysis. We show that MbMR5 from a wild apple species Malus baccata shares 99.4% amino acid sequence identity with MrMR5. Surprisingly, transient expression of MbMR5 in Nicotiana benthamiana showed autoactivity in contrast to MrMR5. Domain swap and mutational analyses revealed that 1 amino acid polymorphism in the MbMR5 CC domain is critical in enhancing autoactivity. We further demonstrated that MrMR5 carrying 7 amino acid polymorphisms present in MbMR5 is not activated by MdRIN4 ACP3 but recognizes AvrRpt2 without MdRIN4 in N. benthamiana. Our findings indicate that naturally occurring polymorphisms of MR5 natural variants can confer its cell death-inducing activity and the effector recognition mechanism likely due to altered compatibility with RIN4.
Cognitive-behavioral therapy (CBT) is an effective treatment for anxiety, yet access to CBT is limited for most families due to the cost, practicalities of attending in-person treatment sessions, and limited availability of trained therapists. Low-intensity telehealth delivery of services is a promising method to improve access to care for youth with anxiety and their families, givens its reachability to a wider range of areas (e.g., rural/underserved) and its ability to minimize practical barriers (e.g., treatment could be delivered to home without need for travel), and reduce stigma (e.g., parents do not need to visit mental health clinics). Additionally, parent-involved treatments for youth anxiety are effective and have the potential to reach more children and adolescents who refuse to see a therapist. However, these interventions have not been widely evaluated. The goal of this project is to evaluate the comparative efficacy and treatment mechanisms of two lower-intensity but effective treatments for families of children with anxiety or obsessive compulsive disorder (OCD) via telehealth compared to an adapted Relaxation and Mentorship Training (RMT) intervention involving breathing exercises with a therapist. This study involves two CBT-based intervention groups, both of which have demonstrated efficacy in prior work: 1) a parent-led, therapist-supported Internet based CBT intervention (iCBT) and 2) parent training paired with bibliotherapy intervention (SPACE).