Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use). 

Important Administration Instructions: Advise patients with new or existing glatiramer acetate prescriptions to consult their pharmacist or healthcare provider if they would like information about using an optional compatible autoinjector device, if available.

Additionally, advise patients who would like to use an autoinjector for administration, should one be available, that not all available autoinjectors are compatible with all glatiramer acetate products and the availability of compatible autoinjectors may change with time. If you have questions about the availability or compatibility of an autoinjector, contact the manufacturer of the prescribed glatiramer acetate product for more information.

Advise patients that using an optional autoinjector that is not compatible with the glatiramer acetate product may increase the risk for medication errors, such as missing a dose or administration of a partial dose [see Warnings and Precautions (5.6)].

Immediate Post-Injection Reaction: Advise patients that glatiramer acetate may cause various symptoms after injection, including flushing, chest pain, palpitations, tachycardia, anxiety, dyspnea, constriction of the throat, and urticaria. These symptoms occur within seconds to minutes after injection and are generally transient and self-limited and do not require specific treatment. Inform patients that these symptoms may occur early or may have their onset several months after the initiation of treatment. A patient may experience one or several episodes of these symptoms. 

Chest Pain: Advise patients that they may experience transient chest pain either as part of the Immediate Post-Injection Reaction or in isolation. Inform patients that the pain should be transient. Some patients may experience more than one such episode, usually beginning at least one month after the initiation of treatment. Patients should be advised to seek medical attention if they experience chest pain of unusual duration or intensity. 

Lipoatrophy and Skin Necrosis at Injection Site: Advise patients that localized lipoatrophy, and rarely, skin necrosis may occur at injection sites. Instruct patients to follow proper injection technique and to rotate injection areas and sites with each injection to minimize these risks. 

Hepatic Injury: Advise patients that hepatic injury, including hepatic failure and hepatitis with jaundice, has been reported with the use of glatiramer acetate injection. Educate patients about the signs and symptoms of hepatic injury and instruct patients to report them immediately to their healthcare provider [see Warnings and Precautions (5.5)].

Pregnancy: Instruct patients that if they are pregnant or plan to become pregnant while taking glatiramer acetate injection they should inform their physician [see Use in Specific Populations (8.1)].

Lactation: Advise patients to notify their healthcare provider if they are breastfeeding or intend to breastfeed during glatiramer acetate injection therapy [see Use in Specific Populations (8.2)].

Instructions for Use: Instruct patients to read the glatiramer acetate injection Patient Information leaflet carefully. Glatiramer acetate injection 20 mg per mL and glatiramer acetate injection 40 mg per mL are not interchangeable. Glatiramer acetate injection 20 mg per mL is administered daily. Caution patients to use aseptic technique. The first injection should be performed under the supervision of a health care professional. Instruct patients to rotate injection areas and sites with each injection. Caution patients against the reuse of needles or syringes. Instruct patients in safe disposal procedures.

Storage Conditions: Advise patients that the recommended storage condition for glatiramer acetate injection is refrigeration at 2˚ to 8˚C (36˚ to 46˚F). If needed, the patient may store glatiramer acetate injection at room temperature, 15˚ to 30˚C (59˚ to 86˚F), for up to one month, but refrigeration is preferred. Glatiramer acetate injection should not be exposed to higher temperatures or intense light. Do not freeze glatiramer acetate injection.