anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients to be randomized to the 'continuous training group' will have exercise training sessions 3 times per week for a period of 12 weeks. During training, they will undergo moderate continuous exercise training at 75% of peak exercise performance.
An alkaloid of empirical formula, C23H30N2O4, characterized by a melting point of 95-96 DEG  C.; an optical rotation of [a ]250 = - 140.6 degrees (concentration: 0.3% by weight in CHCl3) and having specified ultra-violet and infra-red absorption spectra, is produced from the leaves of Mitragyna speciosa by extraction with ethanol. The extract, after removal of ethanol therefrom, is acidified to pH 3-4 with glacial acetic acid and diluted with water.  Insolubles are filtered off and the liquor is cooled to 0-5 DEG  C., adjusted to pH 11 with conc. ammonia and extracted with ether.  The ether is removed and the residue is dissolved in anhydrous ether.  This solution is passed through a chromatographic column of activated alumina and the alkaloid is collected and recrystallized from ethanol.  The alkaloid may be dissolved in anhydrous ether and poured into a solution of hydrogen chloride in isopropanol.  On addition of ether, the hydrochloride salt precipitates. On drying, M.P. of the hydrochloride is 253-254 DEG  C.  M.P.s of the acetate, oxalate, and ethane-disulphonate are specified as being 172 DEG  C.; 219-220 DEG C.; and 272-273 DEG  C. (dec.) respectively.ALSO:A pharmaceutical composition, having antitussive and analgesic activity, comprises a pharmaceutical carrier and a crystalline alkaloid produced from leaves of Mitragyna speciosa, or a nontoxic pharmaceutically acceptable addition salt thereof, said alkaloid having the empirical formula: C23H30N2O4 and characterized by a melting point of 95-96 DEG C. and an optical rotation of [a ]25 DEG  = -140.6 DEG (concentration : 0.3% by weight in chloroform).  The ultraviolet and infra-red absorption spectra are also set forth as characteristics of the alkaloid.  The preferred salt is the ethanedisulphonate.  The carrier may be either solid or liquid.  A time-delay material may be included in the carrier. Administration may be effected orally or parenterally in conventional forms.
NEW MATERIAL:A compound expressed by formula I (X represents H, amino acid reside which may contain protecting group, etc.; Y represents H, alkylacyl which may be substituted, etc.; R<1> and R<2> represent H or alkyl). EXAMPLE:(1-Aminoethyl)(2-L-methionylamino-2-carboxyethyl)phosphinic acid. USE:An antimicrobial agent useful for treating various types of infectious diseases. PREPARATION:For example, phosphinic acids expressed by formula II (W represents amino-protecting group) are reacted with trimethylsilyl chloride in the presence of triethyl amine to afford a silyl ester intermediate expressed by formula III. On the other hand, a chloroalanine derivative expressed by formula IV (Y' represents protecting group-containing amino acid residue or protecting group-containing oligopeptide residue; R represents alkyl) is reacted with triethylamine to afford dehydroalanines expressed by formula V. Then the compound expressed by formula III is added to the compounds expressed by formula V and the product is brought into contact with water.
Growing evidence suggests a need for anxiety and depression treatments that can be disseminated easily to young adults. Many do not seek out treatment for reasons including lack of availability and high cost. There is a growing need for accessible, affordable, research-supported treatments designed to increase the practice of skills and therefore improve treatment outcomes. Graduate students use mobile devices frequently; thus, mobile app-based interventions may be particularly appealing to individuals in this age range with anxiety or depression who are unable to access more traditional psychotherapy administered in person by a therapist.

The study aims to compare the efficacy and feasibility of clinician-delivered cognitive behavior therapy supplemented with the mobile app program to clinician- delivered cognitive behavioral therapy alone. Young adults with anxiety and/or depression will be randomized to clinician-delivered CBT (active control group) or to the clinician CBT + mobile app (intervention group). In the active control group, participants will participate in weekly clinician-delivered Cognitive Behavior Therapy. In the intervention group, participants will participate in weekly clinician-delivered Cognitive Behavior Therapy and use a mobile application for at least 20 minutes two times per week for six weeks.
A flavonic heteroside (I) obtained from roots of Gnidia kraussiana, isolated ina pure state, is new. The genin of this heteroside has the formula C16H1205 and its mol. wt. is 284. The glucides from (I) are glucose and xylose in the ratio 2:1. (I) is an anticancer agent and is active against autoimmune diseases. In its prepn., roots of G.Kraussians are ground and extracted with chloroform to eliminate toxic diterpenoids having epoxide and ether functions between phenolic rings. (I) may then be extracted, e.g. with methanol, and the product purified.
PURPOSE: To obtain a bathing agent composition excellent in ameliorating effect skin pruritus or eczema, capable of giving refreshing feel, also staining no bathing water and bathtub, comprising an Avena sativa Linne extract, aluminum salt and carbonate. CONSTITUTION: This bathing agent composition comprises (A) an extract obtained by extracting seeds of Avena sativa Linne with water and/or a polar organic solvent (e.g. ethanol, butanol, propylene glycol, 1,3-butylene glycol, a mixture thereof), (B) pref. 0.5-20wt.% of an aluminum salt such as aluminum sulfate or aluminum lactate, and (C) pref. 5-98wt.% of a carbonate such as sodium carbonate or potassium bicarbonate. This composition stands adjusted to pH7-10 in the bath water when used therein.
OBJECTIVE: There have been several epidemiologic studies on the association between diabetes mellitus and acute pancreatitis. However, there is no solid evidence, and the effect of diabetes mellitus severity on acute pancreatitis incidence is not well known. This study aimed to evaluate the association between diabetic status and the risk of acute pancreatitis in a nationwide population-based cohort.
METHODS: Among the participants who underwent national health examinations between 2009 and 2012, patients with diabetes mellitus were included. Patients diagnosed with acute pancreatitis before the health examination or diagnosed with pancreatitis within 1 year following the examination were excluded. The association between the number of oral hypoglycemic agents (<3 or ≥3) or insulin use during examination and acute pancreatitis occurrence was analyzed after follow-up until December 31, 2018.
RESULTS: Overall, 2,444,254 patients were included in the final analysis. During the follow-up period, acute pancreatitis occurred in 10,360 patients with an incidence ratio of 0.585 per 1,000 person-years, and it was observed that the risk of acute pancreatitis sequentially increased between patients taking oral hypoglycemic agents <3 (incidence ratio = 0.546), those taking ≥3 (incidence ratio = 0.665), and those using insulin (incidence ratio = 0.872). The adjusted hazard ratios of patients taking three or more hypoglycemic agents and those using insulin were 1.196 (95% confidence interval (CI) 1.123-1.273) and 1.493 (95% CI 1.398-1.594), respectively.
CONCLUSIONS: As diabetes mellitus severity increases, the risk of acute pancreatitis increases.
The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susceptibility to infections. γδ T cells are a subset of unconventional T cells that play crucial roles in host defence against infections. In this study, we aim to determine the roles and functions of γδ T cells in CVID. We observe a higher frequency of Vδ1+ γδ T cells compared to healthy controls, particularly in older patients. We also find a higher proportion of effector-memory Vδ1+ γδ T cells and a more clonal T cell receptor (TCR) repertoire in CVID. The most significant driver of the Vδ1+ γδ T cell expansion and phenotype in CVID patients is persistent cytomegalovirus (CMV) viremia. These findings provide valuable insights into γδ T cell biology and their contribution to immune defence in CVID.
The control group will be receiving the conventional balance training for static and dynamic balance function improvement. The therapy will be provided in sitting or standing (as per the screening result) in a graded manner progressing from fixed surfaces to movable compliant surfaces. The Conventional Balance Training Group will receive a 45-60 minutes of session thrice a week for 12 weeks.
The participants will receive tamoxifen 20mg orally once daily with a glass of water. Each cycle will be defined for 42 days (6 weeks).
<P>PROBLEM TO BE SOLVED: To obtain an oil-in-water type emulsion composition having excellent dispersion stability and good sense of use.  <P>SOLUTION: This oil-in-water type emulsion composition comprises a water phase, an oil phase dispersed in the water phase and powder dispersed in the oil phase. The oil phase comprises ≥50 mass% silicone oil based on the whole amount of the oil phase, an amphiphilic material compatible with the silicone oil and having ≤5 HLB, and an acryl silicone represented by formula (I) [wherein, R is a 10-20C alkyl group; (a), (b) and (c) are each ≥0.2 and satisfy the equation of (a)+b+c=1] as a dispersant of the powder. Preferably, the composition contains 10-30 mass% acryl silicone represented by formula (I) based on the amount of the powder. The composition can contain two or more kinds of powders.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
FIELD: microbiology, medicine. SUBSTANCE: invention relates to the strain of lactic acid bacterium Lactobacillus acidophilus CNCM 1-1225 used as an agent against diarrhea. Invention relates to a composition used against diarrhea also and containing biologically active culture of Lactobacillus acidophilus CNCM 1-1225 and acceptable pharmaceutical or food vehicle. Preferable food vehicle in composition is yoghurt or milk-base powder. Proposed culture and composition based on said exhibit the enhanced capability to displace pathogenic bacteria from intestine cells that are responsible for diarrhea by competition mechanism. EFFECT: enhanced effectiveness of bacterial culture. 3 cl, 1 tbl
In the R33, children will be randomized to receive either COGFLEX with skill-building levels or just baseline/non-probabilistic trials. All children will play COGFLEX twice per week for 8-weeks.
INTRODUCTION: Acute care surgeons are experts in trauma treatment, emergency surgery, and critical surgical care. Here, we analyzed the association of acute care surgeons on postoperative outcomes of emergency general surgery.
METHODS: This retrospective study included 92 patients who underwent emergency general surgery at our institution between January 2020 and September 2021. Propensity score matching was used to analyze postoperative outcomes. The primary outcome was postoperative complications, while secondary outcomes included perioperative management and surgery-related and postoperative complications. Logistic regression analysis was used to estimate the odds ratios for all complications. In this study, acute care surgeons were defined as acute care surgery (ACS)-certified surgeons by the Japanese Society for Acute Care Surgery.
RESULTS: Overall, 30 patients were treated by an acute care surgeon and general surgeons (ACS group), and 62 patients were treated by general surgeons (non-ACS group), respectively. Propensity score matching identified 30 patients with balanced baseline covariates, in each group. The ACS group had lower complication rates (Clavien-Dindo classification ≥2) than the non-ACS group (17% versus 40%, P = 0.08). The ACS group had a significantly shorter surgery duration than the non-ACS group (75 min versus 96 min, P = 0.014). In the logistic analysis, acute care surgeon involvement was identified as an independent predictor for the decrease in all complications (odds ratio, 0.15; 95% confidence interval, 0.02-0.64).
CONCLUSIONS: It was suggested that the involvement of acute care surgeons may reduce the overall complication rate in emergency general surgery.
Hydrochloride preparation method of l-1-/3,4,5-trimetoxibencil/6,7-dihydroxy-1,2,3,4-tetrahidroisoquinolin. Hydrobromide of 3,4-dihydroxyphenylethylamine, tartaric acid (l) and acetic acid is mixed. Gradually added to the mixture, sodium 3-/3,4,5-trimetoxypenyl glicide, in molar relation 1.5-2: 1 with respect to the hydrobromide; it is kept at temperature 40-60ºc for five to twenty hours. L-1-/3,4,5-trimetoxibencil-6,7-dihidroxi-1,2,3,4 tetrahidroisoquinolina-d-tartrate obtained, purifies and suspends in acetone, where it is treated with a hydrochloric acid concentrated. Application as broncodilator. N (Machine-translation by Google Translate, not legally binding)
Patients receive talazoparib PO QD beginning on days -10 to -7 and continuing for up to 8 weeks in the absence of disease progression or unacceptable toxicity. Patients also undergo radiation therapy 5 days a week (Monday-Friday) for up to 7 weeks.
The prevalence of nephrolithiasis is increasing worldwide, reaching 5.2% in North America and 10.1% in Italy. The widespread use of computed tomography and ultrasonography have resulted in a greater detection rate of asymptomatic stones and, in part, might explain the trend. Clinically, kidney or ureteral stones range in severity from asymptomatic to presenting with complete renal failure. Therefore, it is not only the alarming incidence of urinary stone disease, but also the associated burden that makes this one of the most concerning conditions in public health.

The situation becomes even more distressing when managing asymptomatic stones. Studies of the natural history of stones have revealed that only 20% of patients yearly actually become symptomatic from a new stone, and one half of those require surgical intervention at some point. The guidelines are well established for the treatment of symptomatic urolithiasis, and many investigators have extensively studied the management of silent kidney stones. Conversely, the same is not true for silent ureterolithiasis. The purpose of the present study is to report the investigators experience managing silent ureteral stones and to prospectively analyze their true influence on renal function.
Uterine fibroids are the most common female pelvic tumors occurring in about 15% to 30% of women in the reproductive age group. The major problem with myomectomy is excessive bleeding from the increased uterine blood supply. This can be life-threatening, resulting in blood transfusions, febrile morbidity, and potentially in loss of reproductive potential from a hysterectomy. Knowledge of the effectiveness of the interventions used to reduce blood loss during myomectomy is essential to enable evidence-based clinical decisions. Topical application of tranexamic acid(TA) provides a high drug concentration at the site of the wound and a low systemic concentration. Studies from cardiac and orthopedic surgery have shown an equal or superior effect of topical compared with intravenous TA on both bleeding and transfusion requirement. Topical treatment is cost-effective, and adverse effects or drug interactions have not been reported
Pulmonary fibrosis is a challenging lung disease characterized by a bleak prognosis. A pivotal element in the progression of this disease is the dysregulated recruitment of macrophages. Nicotinamide phosphoribose transferase (NAMPT), secreted by alveolar epithelial cells and inflammatory cells, has been previously identified to influence macrophage inflammation in acute lung injury through the nicotinamide adenine dinucleotide (NAD) rescue synthesis pathway. Nonetheless, the exact role of NAMPT in the regulation of lung fibrosis is yet to be elucidated. In our research, we employed bleomycin (BLM) to induce pulmonary fibrosis in Namptflox/flox;Cx3cr1CreER mice, using Namptflox/flox mice as controls. Our findings revealed an augmented expression of NAMPT concurrent with a marked increase in the secretion of NAD and inflammatory cytokines such as IL-6, TNF-α, and TGF-β1 post-BLM treatment. Furthermore, an upsurge in NAMPT-positive macrophages was observed in the lungs of BLM-treated Namptflox/flox mice. Notably, a conditional knockout of NAMPT (NAMPT cKO) in lung macrophages curtailed the BLM-induced inflammatory responses and significantly mitigated pulmonary fibrosis. This was associated with diminished phospho-Sirt1 (p-Sirt1) expression levels and a concomitant rise in mothers against decapentaplegic homolog 7 (Smad7) expression in BLM-treated mouse lungs and murine RAW 264.7 macrophage cells. Collectively, our data suggests that NAMPT exacerbates macrophage-driven inflammation and pulmonary fibrosis via the Sirt1-Smad7 pathway, positioning NAMPT as a promising therapeutic target for pulmonary fibrosis intervention.
The invention relates to a formula of an oral medicine used for treating bone fracture, a preparation method thereof, and an application method thereof. The medicine is composed of medicine materials of, by weight: 10-15 parts of ligusticum, 10-15 parts of yanhusuo tuber, 10-15 parts of white peony root, 10-15 parts of safflower, 10-15 parts of angelica archang lica, 10-15 parts of dipsacus asper, 10-15 parts of ground beetle, 10-15 parts of fortune's drynaria rhizome, 10-15 parts of native copper, 10-15 parts of dragon's blood, 10-15 parts of suberect spatholobus stem, 10-15 parts of eucommia, 10-15 parts of prepared rehmannia rhizome, 10-15 parts of licorice root, and 10-15 parts of radix notoginseng powder. The medicine materials can be prepared into decoctions or pills. According to different phases of the pathogenetic condition of a bone fracture patient, such as an early-stage, a middle-stage or a later-stage, treatments are carried out by using different preparation forms. With the medicine provided by the invention, bone fracture can be rapidly cured with an effective rate of 100%. The medicine application is flexible, and a targeting effect is good. The medicine can be effectively delivered to a bone fracture position, such that the effect of the medicine can be better developed. The oral medicine causes no toxic or side effect.
Twelve subjects will be recruited to evaluate the Enable Oral Hygiene System (EOHS) for safety. Subjects will be asked to complete demographic information and a medical history. An oral exam, including evaluation of oral cavity, soft and hard tissues, will be completed following standard of care procedures. Inclusion/exclusion criteria will be evaluated and eligibility for the study will be determined. Subjects who qualify for participation in the study will receive an EOHS toothbrush with the instructions for use accompanied within the product package. Subjects will then watch an instructional video demonstrating the use of the novel toothbrush. For 28 days, subjects will use the EOHS during normal (self) brushing twice daily. Subjects will be asked to record daily impressions of comfort, ease of use, and perceived cleanliness. At the conclusion of the study, subjects will record overall subjective impressions of comfort, ease of use, and perceived cleanliness. Any device related failures, adverse events, or safety concerns will be recorded. After 28 days, an oral exam, including evaluation of oral cavity, soft and hard tissues, will be completed following standard of care procedures. Subjects will be asked to return daily and overall impression documents as well as the EOHS.
World knowledge about this virus is accumulating but data about the clinical presentations of infected patients and common treatments, including ribavirin, interferon and methylprednisolone, lack evidence. Although drugs with anti- coronavirus (CoV) activities have been identified, as yet no anti- MERs- CoV drug has been approved and a vaccine has yet to be developed. Previous reports on other viral infections including SARS have suggested that convalescent plasma or serum is effective where no other treatment is available or in an emergency. A recently completed systematic review and meta-analysis by the University of Nottingham - World Health Organization Collaborating Center indicates that convalescent plasma therapy may be the most promising near-term therapy patients with for MERS- CoV infection. In this study, investigators will study the pharmacokinetics of immunoglobulin in response to convalescent plasma administration in order to inform a much larger study which will investigate the efficacy of convalescent plasma. Plasma will be collected from patients who recently recovered from MERS-CoV, Health Care Workers who had potential exposure and are tested for anti MERS-CoV serology and RT-PCR after obtaining their consent. This convalescent plasma will be stored in the blood bank as per their policies and procedures. Patients with MERS-CoV positive after meeting the eligibility criteria will receive 2 units of convalescent plasma . Clinical data as well as the standard laboratory studies will be collected at baseline, 30 mins after first dose, 30 mins after second dose, day 1, 3, 7, 14, 28 of hospital stay after enrollment.
A self dosing skin composition and method releases sun blocking agent or other active ingredient onto the skin of a user as a function of exposure to at least one environmental condition over time. The environmental condition is preferably exposure to sun light, in particular, harmful UV radiation. The composition includes a medium adapted to be spread onto the skin of a user and a reservoir defining at least one wall for containing at least one sun blocking or other agent. The reservoir is dispersed in the medium and the wall is designed and/or selected to deteriorate over time with exposure to the environmental condition or conditions, for releasing the agent into the medium and onto the skin. At least one agent is provided in the reservoir. The reservoir is preferably in the form of a multiplicity of microcapsules dispersed in the medium, each microcapsule having a wall containing the at least one agent, each wall deteriorating over time with exposure to the at least one environmental condition for opening the microcapsule to release the agent.
The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden from the organised screening program and the non-organised testing of cervical samples. The cohort started in 2011 and has enrolled more than 670,000 women, contributing with more than 1.2 million biobanked samples. The cohort is systematically updated with individual-level data from the Swedish National Cervical Screening Registry (NKCx). Key variables include birthdate, sampling date, cytological, histopathological and HPV analysis results, and invitation history. Each sampling and subsequent clinical follow-up is sequentially registered, allowing for longitudinal analyses of screening results and associated results of the clinical workup. The cohort is ideal for longitudinal, long-term follow-up studies due to its validated documentation and registry-derived information. From the data, it is possible to penetrate important human health mechanisms. The data are available as open-data and GDPR-compliant. Samples are available after getting the required permissions. Results will help researchers understand factors that increase cancer risk and other diseases.