anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Bariatric surgery is the most effective intervention for severe obesity and associated co-morbidities. However, around 2 years after surgery, a substantial proportion of patients struggle with weight regain, psychological complications (e.g., disordered eating, depression), and relationship challenges. To achieve optimal long-term outcomes, a biopsychosocial focus and treatment approach is critical. Existing interventions primarily target weight, occur at the individual patient level, use a risk-based or problem-focused lens, and are inaccessible to the average patient. In contrast, this proposed research will test feasibility, acceptability, and preliminary efficacy of an intervention to improve psychosocial health, occurring at the dyadic (patient and partner) level, using a strengths-based or positive psychology lens, and remotely-delivered for accessibility. This multi-faceted approach is needed to address the high rate of psychiatric disorders and lack of social support among bariatric surgery patients that compromises long-term surgical outcomes. Patients in relationships report inconsistency in support provision from partners, lose less weight than those not in relationships, and are at elevated risk of divorce post-surgery. The investigator(s) research has demonstrated declines in relationship satisfaction from before to after surgery, and associations with elevated levels of binge eating, anxiety, and social stress 2 years after surgery. The investigator(s) has also documented the importance of adaptive coping, social support, and resilience for improved mental health and eating behaviors in this stigmatized population. In combination, existing research supports the need for dyadic-level and strengths-focused intervention to prevent exacerbation of psychological distress and difficulties in long-term weight management.

The investigator and research team have utilized pilot grant funding to adapt an evidence-based dyadic positive psychology intervention (dPPI) for post-bariatric surgery patients and their partners. This intervention was developed in a two-phase, mixed-methods study. The investigator first obtained feedback from 6 patients and partners in focus groups about relationship health following bariatric surgery and intervention needs. The investigators then asked these couples to pilot test 4 adapted intervention modules and obtained quantitative and qualitative feedback, which suggested high satisfaction with and benefit from the intervention modules. This study resulted in a finalized 8-module, remotely-delivered dPPI with content consisting of activities (expressing gratitude, practicing acts of kindness, fostering relationships, focusing on the positive, savoring, working toward goals, meaning finding/values, planning for the future) completed individually and as a couple. The dPPI is now ready for formal testing of feasibility, acceptability, and preliminary efficacy in a pilot randomized clinical trial (RCT).
The Knee Control+ is an extension of the original Knee Control exercise program offering a wider selection of exercises (to increase adherence) and more physically challenging exercises (adapted for athletes in the late teens and provide further stimuli to increase player performance and neuromuscular function). The program will be performed during the warm-up to each football practice (at least twice per week) during the 12 week intervention period.
Participants will receive an oral administration of prednisolone or placebo two times daily for the first five days of opioid detoxification, starting after one day of regular detoxification as baseline. Oral prednisolone will be administered in a dose consistent with standard treatment guidelines for glucocorticoid deficiency (Oelkers, 1996).
The present invention relates to golden Shaoxing wine. When the golden Shaoxing wine is frequently drunk, the golden Shaoxing wine can lower the blood pressure of a person with high blood pressure to a normal level and can also return the blood pressure of a person with low blood pressure to the normal level. The golden Shaoxing wine can automatically adjust the function of a human body and can enhance the quality of blood, and therefore, the golden Shaoxing wine achieves the disease resistance action and the immunological function of the human body and prevents cardio-cerebrovascular diseases, osteoporosis and senile dementia. The golden Shaoxing wine is suitable for patients with cardio-cerebrovascular diseases and normal persons, the golden Shaoxing wine can treat the diseases for the patients, and the golden Shaoxing wine can also prevent diseases and strengthen the body for healthy persons. The implementation method of the present invention comprises the following steps: 200 to 300 g of eucommia bark, 150 to 250 g of fortune silene herb with root, 200 to 300 g of kendir and 250 to 400 g of Chinese chestnut (shelling) are taken as raw materials, and the raw materials are purified and are coarsely crushed for stand-by application; 100 kilograms of glutinous rice are brewed according to a production technology of yellow wine. In the production technology of yellow wine, the raw materials for the stand-by application are put into wine liquid with sediment after a main fermentation period, the fermentation of a later period of the wine is completed, and the golden Shaoxing wine can be obtained after a mature fermentation product is squeezed, sterilized and stored for a certain time.
The project performs community sensitisation and mobilisation in dedicated geographical areas and populations, to inform women and relatives about the importance of screening for cervical cancer.

To eligible women self-tests for hrHPV are offered, which can be applied at home and investigated in dedicated field-laboratories. Women who are hrHPV positive are invited for further diagnosis. In Uganda, India and Bangladesh Visual Inspection of the cervix with Acetic Acid is performed. In Slovakia Pap-smear. In case dysplasia is found, further treatment is performed with cryotherapy or thermo-ablation. Cases of suspect invasive cervical cancer are referred to hospitals for diagnosis and treatment.
The invention provides a set of anti-HIV oligonucleotides and a method for use thereof for prevention and treatment of AIDS. Nucleotide sequences are presented as tables of sequences. The invention exceeds prior technologies due to:highly conserved RNA sequences obtained by comparing of all published HIV gene sequences. Double strand RNA sequences derived from sequences are effectively inhibit HIV gene expression. The HIV gene expression is also inhibited by the double strand hairpin RNA transcribed in cells by transfacted with recombinant plasmids which contain DNA sequences encoding RNA sequences. Besides, the HIV gene expression is suppressed in a cell with transcribed dsRNA, corresponding to RNA sequences encoded by recombinant adenovirus-associated virus.
BACKGROUND: Children's bone loss of limbs represents a significant challenge for surgeons, especially given that children are growing individuals. In the pediatric population, we compared bone reconstruction using vascularized fibula flaps with the induced membrane technique. The primary purpose of this study was to evaluate the delay and quality of consolidation.
METHODS: Data from patients who underwent limb reconstruction using either the fibula flap or the induced membrane were retrospectively collected from files across two centers. Perioperative and long-term complications were documented, along with functional and aesthetic outcome.
RESULTS: Between 2004 and 2020, 31 children underwent limb reconstruction using a fibula flap, and 13 patients were treated using the induced membrane technique. The etiologies included 76% tumors, 20% congenital pseudarthroses, and 3.7% infections. The median size of the bone resection was 12.5 cm (range: 1.8 to 31 cm). The median time to consolidation after free fibula flap transfer was 10 months (range: 2 to 55 months) versus 7.5 months (range: 1 to 64 months) for the Masquelet technique (p = 0.54). Limb length inequality occurred in 52% of fibula cases and 39% of the induced membrane cases (p = 0.55).
CONCLUSIONS: Both of free fibula flap and the induced membrane technique are effective options for bone reconstructing long bones in children. These techniques yield good functional outcomes and have comparable consolidation times.
The invention provides for a means of aligning a first virtual object with a second virtual object that is different from the first virtual object within a scene volume in a  3 D virtual space. The method includes performing a  3 D scan of the user's head to get the first virtual object. The second virtual object comprises a  3 D model of a mask. The method further determining a location of a first surface point on a surface of the first virtual object based on a first ray casting of the first virtual object, and determining a location of a second surface point on a surface of the second virtual object based on a second ray casting of the second virtual object. The second surface point has a desired positional relationship with respect to the first surface point. The first ray casting originates from outside the scene volume and the second ray casting originates from inside the scene volume. A relative position between the location of the first surface point and the location of the second surface point is then determined and the location of the second surface point is adjusted based on the relative position.
Patients in this group will undergo an ilioinguinal-iliohypogastric nerve block in the supine position under ultrasound guidance after LMA with 0.25% Buvasin® 0.5ml/kg. PI, PVI, pulse, saturation, noninvasive arterial pressure values before induction, after induction, after LMA, before applied block, after applied block (after surgical incision) 0., 5., 10., 15., 20., 25. It will be recorded at the 30th and 30th minutes and at the end of anesthesia. PI, PVI will be monitored with Radical-97TM Pulse CO-OximeterTM (Masimo Corp, Irvine, CA, USA) probe.
The study will prospectively include patients referred to our department for EUS and EUS-FNA of suspected pancreatic masses during a 12 months period. The indication for this investigation will be based on the patient's clinical history and previous imaging studies (abdominal ultrasound, CT scan, MRI).
AIMS: To assess the outcomes of robotic surgery for patients with neurogenic lower urinary tract dysfunctions (NLUTD).
MATERIALS AND METHODS: Studies evaluating the outcomes (efficacy and safety) of robot-assisted ileal conduit creation or artificial urinary sphincter (R-AUS) implantation or augmentation cystoplasty or continent urinary diversion creation in patients with NLUTD were included. The search strategy and studies selection were performed on Medline, Embase and Cochrane using the PICOS method according to the PRISMA statement (PROSPERO 2022 CRD42022333157). The comparator, if available, was the use of open or laparoscopic technique. Meta-analysis was performed whenever possible. The remaining articles were synthesized narratively.
RESULTS: Eight articles were included. Five described the outcomes of robot-assisted cystectomy with ileal conduit creation, two described the outcomes of augmentation cystoplasty and continent urinary diversion creation and one described R-AUS implantation in patients with NLUTD. The risk of bias was high. Three articles comparing the outcomes of robotic and open cystectomy and ileal conduit creation were suitable for meta-analysis. According to our meta-analysis, robot-assisted surgery had better outcomes compared to open surgery in terms of high-grade early postoperative complications (OR 0.39; 0.19-0.79; p = 0.01), days to bowel recovery (Cohen's D = - 0.62  ± 0.14, p < 0.001), length of hospitalisation (Cohen's D = - 0.28 ± 0.13; p = 0.03) and estimated blood loss (Cohen's D = - 1.17 ± 0.14, p < 0.001).Regarding AUS implantation, augmentation cystoplasty and continent urinary diversion creation, the outcomes from the articles included in our systematic review showed a 16-40% overall early complication rate in case of augmentation cystoplasty and 22% in case of AUS implantation.
CONCLUSIONS: Robot-assisted surgery may have several advantages over open surgery in the treatment of NLUTDs. However, current evidence is insufficient to draw firm conclusions. Further high-quality studies are needed to better understand the role of robotic surgery in the treatment of NLUTD.
A system and a method to obtain clearance is disclosed. The system includes user identification hardware configured to establish identity of the user. The system also includes a toilet configured to analyze a sample of excreta or sputum from the user, to thereby determine the status of the user with respect to a pre-determined condition. A processing module is configured to link the identity of the user with the status of the user. A communication module communicates information including the linked identity and status of the user to an authority. As such, the authority is provided the information required to grant or deny clearance to the user. Clearance may include allowing a user to use one or more forms of public transportation, be in places where large numbers of people congregate, participate in an athletic competition or other places or activities where the condition of the user may put themselves or others at risk.
A formulation comprising at least one naturally occurring oil for use in a method of reliving dry eye, wherein the method comprises applying said formulation to the eyelid margin, wherein the formulation is free of preservatives and comprises less than 5.0 % of water. Preferably, the concentration of the oil in the formulation may be 97% to 99%. The oil may be linear or branched, saturated or unsaturated. The chemical structure of the oil may comprise one, two or three substituents. The oil may be made up of 10 to 40 carbon atoms. The naturally occurring oil is preferably selected from jojoba oil, sweet almond oil, soybean oil, or castor oil, preferably Simmondsia chinensis oil or Ricinus communis oil. The formulation may be about 71.6% v/v jojoba oil, about 3% v/v castor oil, about 24 v/v% sweet almond oil, and about 0.4 % vitamin E oil.
The intervention arm involves children and adolescents with unknown HIV status, aged between 6 weeks to 19 years, born to parents living with HIV/AIDS. These children will be identified for HIV testing through their parents diagnosed with HIV or receiving HIV care in the hospital.
Participants in the clinical group will receive usual pharmacological treatment and undergo a protocol of 12 Acceptance and Commitment Therapy sessions, in group format, during 3 months. The intervention will be held weekly, with an estimated duration of 2 hours for each session, in addition to the participants' regular drug treatment. Scales are administered at the beginning and end of treatment, with follow-ups after 3 and 6 months.
AIM: We tested the hypothesis that visual field (VF) progression can be predicted with a deep learning model based on longitudinal pairs of optic disc photographs (ODP) acquired at earlier time points during follow-up.
METHODS: 3919 eyes (2259 patients) with ≥2 ODPs at least 2 years apart, and ≥5 24-2 VF exams spanning ≥3 years of follow-up were included. Serial VF mean deviation (MD) rates of change were estimated starting at the fifth visit and subsequently by adding visits until final visit. VF progression was defined as a statistically significant negative slope at two consecutive visits and final visit. We built a twin-neural network with ResNet50-backbone. A pair of ODPs acquired up to a year before the VF progression date or the last VF in non-progressing eyes were included as input. Primary outcome measures were area under the receiver operating characteristic curve (AUC) and model accuracy.
RESULTS: The average (SD) follow-up time and baseline VF MD were 8.1 (4.8) years and -3.3 (4.9) dB, respectively. VF progression was identified in 761 eyes (19%). The median (IQR) time to progression in progressing eyes was 7.3 (4.5-11.1) years. The AUC and accuracy for predicting VF progression were 0.862 (0.812-0.913) and 80.0% (73.9%-84.6%). When only fast-progressing eyes were considered (MD rate < -1.0 dB/year), AUC increased to 0.926 (0.857-0.994).
CONCLUSIONS: A deep learning model can predict subsequent glaucoma progression from longitudinal ODPs with clinically relevant accuracy. This model may be implemented, after validation, for predicting glaucoma progression in the clinical setting.
BACKGROUND: Pulsed-field ablation (PFA) is a nonthermal method for achieving selective cell death with little inflammation response. However, there are no reports of PFA for septal reduction therapy (SRT).
OBJECTIVE: The purpose of this study was to investigate the effectiveness and safety of PFA for SRT.
METHODS: A novel transvenous intraseptal PFA method with 3-dimensional (3D) guidance was introduced in Yorkshire pigs. Electrocardiographic parameters, transthoracic echocardiography, and histopathology were used to evaluated.
RESULTS: The maximum injury diameter of intramyocardial PFA increased with electric field intensity. After PFA, bipolar electrogram amplitude and pacing threshold measured by the PFA electrodes significantly decreased (F = 6.945, P = .007) or increased (F = 5.842, P = .024), respectively. In the ablated septal region, motion amplitude and systolic wall thickening rate significantly decreased and remained at low levels (motion amplitude: F = 20.793, P = .000; systolic wall thickening rate: F = 14.343, P = .000); however, septal thickness did not significantly change after PFA (F = 1.503, P = .248). Histologic examination showed specific cardiomyocyte death with gradually increased hyperchromatic cytoplasm and nuclear pyknosis, without obvious inflammatory cell infiltration in acute phase. TUNEL stain for fragmented DNA showed extensively positive in the ablation region 24 hours after PFA. During PFA, no sustained ventricular arrhythmia or atrioventricular conduction block occurred.
CONCLUSION: A novel intraseptal PFA method with 3D guidance was described. Intraseptal PFA resulted in effective myocardial injury and local hypokinesis without significant acute edema. Histologic examination showed widely programmed cardiomyocyte death with little inflammatory cell infiltration.
FIELD: medicine, immunology. SUBSTANCE: invention relates to methods used for treatment and prophylaxis of immune insufficiency. Method involves the use of extract of fresh porcine donor spleen as a biosubstrate. Extract is prepared by placing spleen slices with diameter 0.3-0.5 cm in sodium chloride isotonic solution. Prepared extract is given orally before eating in the dose 10-15 ml, 3 times per 24 h. The treatment course is 1-4 weeks. Method ensures to simplify a procedure of biosubstrate preparing and minimize risk of possible complications arising. EFFECT: improved method of treatment and prophylaxis, simplified method of preparing. 3 cl
NEW MATERIAL:A plasminogen activating factor. Molecular weight: 63,000 + or -10,000. Isoelectric point: 7.0-8.5. Affinity for both fibrin and concanavalin A. Fittest pH: 7.0-9.5. Not reacting with an antiurokinase specific antibody. USE:A fibrinolytic agent. PREPARATION:A cell (e.g., cell derived from human lung, foreskin, etc.,), a normal diploid cell derived from human, capable of forming a plasminogen activating factor having high affinity for fibrin, is brought into contact with a solution containing both a peptone of animal meat decomposition with an enzyme or a peptone derived from a plant and kinin or the peptone of animal meat decomposition with an enzyme or the peptone derived from a plant and thrombin, to give the plasminogen activating factor. The factor is obtained in high yield by using >=0.2ml culture solution based on 100,000 cells at 25-40 deg.C at 6.0-8.0.
Approximately 9 x 10\^6 DCs will be injected (subcutaneously)total per vaccination visit. Patients will receive four vaccinations at weeks 0, 4, 8 and 12.At each scheduled vaccination the patient will receive a total of 3 injections, i.e., 3 mL injections at each of 3 anatomical locations.Injection sites are in upper and lower extremities. Subsequent DC injections will be rotated to different locations on the upper and lower extremities.
Honey is referred to in the Qur'an as a wound healing agent (QS: 16:68 - 69) and has antimicrobial, antioxidant and anti-inflammatory effects. Honey, as an anti-inflammatory, has components of hydrogen peroxide, flavonoids, and phenolic acids that play a role in stimulating angiogenesis (8). Honey also has a high osmolality which provides moisture to the wound, thereby reducing edema and hyperemia and functioning as an antibacterial, so it is expected to reduce the use of antibiotics. Research reported in 2012 stated that honey had the same effect on wound healing and perineal wound pain in postpartum mothers with routine use two times a day for five days (P \< 0.05) (9).
Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

1\. Primary hypogonadism (congenital or acquired )-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.

2\. Hypogonadotropic hypogonadism (congenital or acquired) - gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Safety and efficacy of Testosterone Cypionate Injection in men with "age-related hypogonadism" (also referred to as "late-onset hypogonadism") have not been established.
Telerehabilitation programme: Each patient will use a telehealth monitor and measure blood pressure, pulse and weight once or twice a week over a 3 months periods with the use of a blood pressure monitor and a weightscale connected to the monitor. The patients will also measure their steps daily by the use of a digital step-counter. The patients will be able to see their data in a personal health record on a tablet where they can share informations with healthcare professionals. The patient are also offered access to a portal called www.aktivehjerte.dk where they can find informations on rehabilitations topics in text, video and sound. The patients are randomised in block of different sizes to follow rehabilitation from hospital, healthcare center or a callcenter.
PURPOSE:To provide the titled emulsion having slow-releasing property, focal selectivity, and low side effect, applicable by intravenous injection, and useful as a drug such as vasodilator, hypotensor, etc., by using a fat emulsion containing prostaglandin E1 alkyl ester. CONSTITUTION:A fat emulsion containing the prostaglandin E1 alkyl ester of e.g. formula (R is 1-30C alkyl) (abbreviated as PGE1E) is used as the titled agent. The fat emulsion is composed mainly of 5-50w/v% of soybean oil, 1- 50pts.wt., preferably 5-30pts.wt., based on 100pts.wt. of the soybean oil, of a phospholipid, and a proper amount of water. It may contain emulsification assistant, stabilizer, etc. The preparation is resistant to the inactivation of the drug component found frequently in the conventional PG preparation, and can be administered by intravenous injection. It has stable drug action, and is effective at a low dose.