anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: The prevalence and incidence of Nonalcoholic fatty liver disease (NAFLD) are increasing worldwide, and NAFLD has emerged as a prominent global health concern. The link between serum alanine aminotransferase (ALT) to aspartate aminotransferase (AST) ratio and NAFLD remains unclear. This study investigated the association between the ALT/AST ratio and NAFLD prevalence, including liver steatosis and fibrosis levels in the population.
METHODS: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018, including 4753 participants. Subgroup analyses, stratified by age, gender, and body mass index (BMI), were performed, along with adjusted multivariable logistic regression analyses to evaluate the relationship between ALT/AST levels and the likelihood of NAFLD, liver steatosis, and hepatic fibrosis stage. A generalized additive model examined the non-linear relationship between ALT/AST and the probability of developing NAFLD.
RESULTS: Among 4753 participants, 1508 (31.73%) were diagnosed with NAFLD. Significant positive correlations between ALT/AST and NAFLD risk were found across all models. In addition, the subgroup analysis by gender, age, and BMI suggested that ALT/AST showed a positive correlation with NAFLD. The ALT/AST ratio was positively correlated with the degree of liver steatosis and liver fibrosis. The correlation between ALT/AST and the incidence of NAFLD showed a non-linear pattern. In women, the non-linear trend is particularly evident, showing an inverted U-shaped curve with an inflection point of 1.302. A receiver operating characteristic (ROC) analysis showed that the predictive value of ALT/AST for NAFLD was better than that of traditional liver enzyme parameters.
CONCLUSION: A higher ALT/AST ratio was independently associated with a significantly higher risk of NAFLD and liver fibrosis within American cohorts. This link is robust among females, children, and adolescents. ALT/AST ratio can be used as a simple and effective noninvasive biomarker to identify individuals with high risk of NAFLD.
Compsn. for long-lasting hair styling is based on a keratin-reducing cpd (I), contains no mercapto carboxylic acid esters, and has a pH of 7-7.5. The compsn is prepd. immediately before use by mixing a component A with a component B, where component A contains (I) and has a pH below 7, and component B contains a buffer system and has a pH of 8-10. Also claimed is a long-lasting hair styling process comprising treating the hair with the above compsn. before and/or after styling it; rinsing with water; subjecting the hair to oxidative treatment; rinsing with water; opt. water-waving the hair; and drying the hair.
Use of flavin derivatives and their salts for preparing a medicament for the treatment of pathologies of the internal limiting membrane (ILM), is claimed. The flavin derivative is riboflavin or roseoflavin, which can be photodynamically degraded by a irradiation from an intra- or extravitreal light source with a wavelength of 500 nm and an effective intensity of 5 mW/cm 2>, after an intravitreal application of the ILM. The ILM or the its adjacent structures are generated by a mechanical stabilization. ACTIVITY : Ophthalmological. Test details are described but no results given. MECHANISM OF ACTION : None given.
There are several modifiable factors that can be targeted to prevent and manage the occurrence and progression of cancer, and maintaining adequate exercise is a crucial one. Regular physical exercise has been shown to be a beneficial strategy in preventing cancer, potentially amplifying the effectiveness of established cancer therapies, alleviating certain cancer-related symptoms, and possibly mitigating side effects resulting from treatment. Nevertheless, the exact mechanisms by which exercise affects tumors, especially its impact on the tumor microenvironment (TME), remain uncertain. This review aims to present an overview of the beneficial effects of exercise in the context of cancer management, followed by a summary of the exercise parameters, especially exercise intensity, that need to be considered when prescribing exercise for cancer patients. Finally, we discuss the influence of exercise on the TME, including its effects on crucial immune cells (e.g., T cells, macrophages, neutrophils, natural killer cells, myeloid-derived suppressor cells, B cells), intratumor angiogenesis, and cancer metabolism. This comprehensive review provides up-to-date scientific evidence on the effects of exercise training on cancer and offers guidance to clinicians for the development of safe and feasible exercise training programs for cancer patients in clinical practice.
This study will be a randomized controlled trial involving 30 participants, with data collected from the Sanai school system in Sargodha. The study will include school-aged children with normal weight between the ages of 10 and 14. Children with any cardiorespiratory conditions, hemophilia, muscular dystrophy, or a history of cardiovascular events will be excluded. The sample of 30 will be divided into two groups of 15 participants each. Group A will participate in tai chi exercises across three levels, while Group B will engage only in basic arts and crafts activities. The interventions will consist of 10 sessions, conducted at a rate of 5 sessions per week over 2 weeks. To assess the respiratory fitness of the children, data will be collected using the 6-minute walk test and the Timed Up and Go test. Data analysis will be performed using SPSS version 26.0.
Neonatal sepsis is a catastrophic condition of global concern, with reported mortality rates exceeding 10%. Bloodstream infections are an important cause of sepsis, and epidemiological studies of these infections are crucial for predicting the most common aetiological agents and antimicrobial susceptibility patterns and for developing antimicrobial guidelines. For the ten-year study period from July 2013 to June 2023, all neonatal bacteraemia cases were reviewed prospectively using an enhanced surveillance protocol. The patients were stratified according to their age at the time of blood culture collection: early onset if diagnosed in the first 72 hours of life, and late onset if diagnosed after that time. During the study period, 170 blood cultures were positive from 144 patients, of which 89 specimens from 64 patients represented the growth of significant pathogens. Coagulase-negative staphylococci (CoNS) were the most common pathogens identified (52%, 33/64), followed by Escherichia coli (14%, 9/64), Group B Streptococcus (GBS: 11%, 7/64) and Staphylococcus aureus (11%, 7/64). GBS was more commonly identified in early onset patients, while CoNS were predominantly associated with late onset. The presence of an intravascular catheter, maternal urinary tract infections and the receipt of total parenteral nutrition or transfused blood were identified as significant risk factors. The fatality rate was 8% (5/64). in summary, this study provides a detailed overview of the epidemiology of neonatal bacteraemia in a large teaching hospital in the Midwest of Ireland over a decade.
PURPOSE: A composition for anticancer including KRT19 antibody is provided to obstructing physical coupling between KRT19-HER2 by using KRT19 antibodies, thereby Preventing, reducing, and treating diseases related to the HER2 including breast cancer. CONSTITUTION: A composition for anticancer includes KRT19 antibody which complementarily unites with KRT19 protein as an active ingredient. The KRT19 consists of amino acid sequence which is represented by sequence number 1[SEQ ID NO:1]. The KRT19 antibody targets 78-330th sequences among the amino acid sequences represented by sequence number 1. The KRT19 antibody is a monoclonal antibody. The KRT19 antibody obstructs physical coupling between HER2 and KRT19.
INTRODUCTION: This study sought to assess the association between the changes in nonalcoholic fatty liver disease (NAFLD) and risk of type 2 diabetes in young individuals with prediabetes.
METHODS: Data from the Korean National Health Insurance System database were collected from 2009 to 2019 and analyzed in 2022. A total of 446,813 young adults aged 20-39 years with prediabetes who underwent two National Health Screening examinations from 2009 to 2012 were followed up. NAFLD was defined as a fatty liver index≥60 without liver disease or history of alcohol abuse. Multivariable Cox proportional hazards regression was used to calculate the HR and CIs for type 2 diabetes according to NAFLD changes.
RESULTS: During a median follow-up of 8.3 years, 26,464 (5.9%) young individuals developed type 2 diabetes. Multivariable adjusted HR of type 2 diabetes according to the NAFLD change was 5.38 (95% CI 5.08-5.70) in individuals with persistent NAFLD when compared to those who never had NAFLD. Even in individuals who were consistently nonobese, resolved NAFLD, new NAFLD, and persistent NAFLD were associated with>3-fold increased risk of type 2 diabetes compared to nonobese individuals without NAFLD. The risk of type 2 diabetes also increased in obese individuals without NAFLD by 2-fold when compared to nonobese individuals without NAFLD.
CONCLUSIONS: NAFLD that either existed persistently or ever existed plays a critical role in the development of type 2 diabetes in young adults with or without obesity. Nonobese individuals with NAFLD warrant special attention.
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and health care use worldwide with heterogeneous pathogenesis. Mitochondria, the powerhouses of cells responsible for oxidative phosphorylation and energy production, play essential roles in intracellular material metabolism, natural immunity, and cell death regulation. Therefore, it is crucial to address the urgent need for fine-tuning the regulation of mitochondrial quality to combat COPD effectively. Mitochondrial quality control (MQC) mainly refers to the selective removal of damaged or aging mitochondria and the generation of new mitochondria, which involves mitochondrial biogenesis, mitochondrial dynamics, mitophagy, etc. Mounting evidence suggests that mitochondrial dysfunction is a crucial contributor to the development and progression of COPD. This article mainly reviews the effects of MQC on COPD as well as their specific regulatory mechanisms. Finally, the therapeutic approaches of COPD via MQC are also illustrated.
Patients attend Tai Chi Easy class for 60 minutes once a week for 6 weeks. Patients also receive a DVD and exercise manual of Tai Chi Easy exercises and are encouraged to practice at home for 30 minutes most days per week for 6 weeks.
Primarily unilateral bronchoscopic lung volume reduction by endobronchial valves. If a bilateral procedure is feasible it must be performed within 3 months after the first intervention.
OBJECTIVE: This study was developed to explore the incidence of multi-drug resistant organism (MDRO) infections among ruptured intracranial aneurysms(RIA) patient with hospital-acquired pneumonia(HAP) in the neurological intensive care unit (NICU), and to establish risk factors related to the development of these infections.
METHODS: We collected clinical and laboratory data from 328 eligible patients from January 2018 to December 2022. Bacterial culture results were used to assess MDRO strain distributions, and risk factors related to MDRO infection incidence were identified through logistic regression analyses. These risk factors were further used to establish a predictive model for the incidence of MDRO infections, after which this model underwent internal validation.
RESULTS: In this study cohort, 26.5 % of RIA patients with HAP developed MDRO infections (87/328). The most common MDRO pathogens in these patients included Multidrug-resistant Klebsiella pneumoniae (34.31 %) and Multidrug-resistant Acinetobacter baumannii (27.45 %). Six MDRO risk factors, namely, diabetes (P = 0.032), tracheotomy (P = 0.004), history of mechanical ventilation (P = 0.033), lower albumin levels (P < 0.001), hydrocephalus (P < 0.001) and Glasgow Coma Scale (GCS) score ≤8 (P = 0.032) were all independently correlated with MDRO infection incidence. The prediction model exhibited satisfactory discrimination (area under the curve [AUC], 0.842) and calibration (slope, 1.000), with a decision curve analysis further supporting the clinical utility of this model.
CONCLUSIONS: In summary, risk factors and bacterial distributions associated with MDRO infections among RIA patients with HAP in the NICU were herein assessed. The developed predictive model can aid clinicians to identify and screen high-risk patients for preventing MDRO infections.
Interventions: Selinexor, Fludarabine, and Cytarabine. Methotrexate/hydrocortisone/cytarabine (intrathecal triples) will be given prior to cycle 1.
The present invention relates to long-lasting therapeutic formulations and a method of providing a therapeutic polypeptide to a subject in need over a sustained period. The long-lasting therapeutic formulations comprises genetically modified micro-organs, said micro-organs being dermal micro-organs utilizing helper-dependent adenovirus vector to perform in transduction in vitro. The vector comprising a nucleic acid sequence operably linked to one or more regulatory sequences, wherein the one or more regulatory sequences may comprise a CAG promoter. The micro-organs are maintained ex vivo for one to eight weeks. The nucleic acid sequence encodes a therapeutic polypeptide, such as erythropoietin or interferon alpha. After the long lasting drug formulations are implanted, the formulations are capable of b. increasing expression levels of said therapeutic polypeptide by more than 5% over basal level and/or a. said increase is maintained for greater than one month.
Lung cancer is the leading cause of cancer morbidity and mortality worldwide. The majority of lung cancer is nonsquamous NSCLC. EGFR tyrosine kinase inhibitors (EGFR-TKI) is a effective first-line treatment for EGFR mutations non-squamous NSCLC treatment. But those patients without epidermal growth factor receptor (EGFR) mutations show a poorer prognosis. Gemcitabine combined with cisplatin chemotherapy is an effective treatment measures for EGFR mutation-negative NSCLC patients, but the prognosis remains poor. Chemotherapy combined with targeted monoclonal antibody treatment may be better treatment options in these patients. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Bevacizumab blocks the ability of tumors to grow new blood vessels and spread. This randomized trial studies how well giving cisplatin and gemcitabine alone or in combination with Bevacizumab (Avastin) works in treating patients with stage IIIB/IV non-squamous NSCLC without EGFR mutations. Accordingly, we have come to a scientific hypothesis that cisplatin and gemcitabine combination with Bevacizumab might be a better treatment strategy for stage IIIB/IV non-squamous NSCLC patients with EGFR wild-type. It can improve the PFS of stage IIIB/IV non-squamous NSCLC patients with EGFR wild-type. The primary endpoint is disease-free time to progression (PFS). The secondary study endpoint is objective response rate (ORR), disease control rate (DCR), safety and quality of life (QOL). Through this study lay the foundation for further exploration of the non-squamous NSCLC first-line treatment in patients with EGFR wild-type strategy, and guide the rational application of bevacizumab.
The invention discloses a body fluid small molecule metabolic marker of zebra fish infected bacteria, which is at least one of glutamine, lactic acid, serine and glycine, preferably glutamine. The bacteria are selected from Vibrio parahaemolyticus. The invention also discloses application of glutamine in improving immunity of zebra fish responding to vibrio parahaemolyticus infection, and application of glutamine in preparing a medicine or health-care product for improving immunity of zebra fish responding to vibrio parahaemolyticus infection. Application of glutamine in regulation of zebra fish galactose metabolism and application in regulation of a zebra fish aminoacyl tRNA biosynthetic metabolic pathway. Experiments show that the glutamine plays an important role in response to bacterial infection of the zebra fish, plays an extremely important role in innate immune response of the zebra fish, and can be used for research on the functions of metabolome, detection and treatment of bacteria infected by the zebra fish and the like. The invention has important reference value for the research of the metabonomics related to the immune response of the zebra fish responding to bacterial infection.
The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiol 
     This invention was made in part with government support under the National Science Foundation Presidential Young Investigator Award (1986) to J. L. Sessler, grant CHE-8552768. The government has certain rights in the invention.
The invention discloses a molecular targeting anticancer photosensitizer phthalocyanine-erlotinib yoke compound, and preparation and application thereof. Erlotinib with a long alcoxyl chain is introduced at the periphery of a metal phthalocyanine ring, so that the amphipathy, the bioco mpatibility and the targeting effect of the photosensitizer can be increased. The yoke compound is not easily gathered, which is favorable for improvement of the cell uptake rate; meanwhile, since the compound is single in structure and no isomer exists, the product is easily purified. By adopting the compound, the targeting effect of the photosensitizer in photodynamic therapy is expected to be improved; and meanwhile, the activity of the photosensitizer in the photodynamic therapy is enhanced. The synthesis method of the phthalocyanine-erlotinib yoke compound is simple, involves less side reactions, is high in yield and low in cost; moreover, the raw materials are easily available. Therefore, industrial production is facilitated.
Group 3: 10 volunteers will receive 1 x 10\^7 cfu aerosol inhaled BCG (Arm A) and 3 volunteers will receive aerosol inhaled normal saline placebo (Arm B). All Group 3 volunteers will have a bronchoscopy 14 days post challenge Volunteers in group 7 and group 3 (arm A) will be offered an optional follow up at 12 months, in order of enrolment until 10 such visits have been conducted. For group 3 volunteers this will be offered after unblinding.
Neurotoxicity associated with chemotherapy is a debilitating side effect of cancer management in humans which reportedly involves inflammatory and oxidative stress responses. Diphenyl diselenide (DPDS) is an organoselenium compound which exhibits its anti-tumoral, anti-oxidant, anti-inflammatory and anti-mutagenic effects. Nevertheless, its possible effect on chemotherapy-induced neurotoxicity is not known. Using rat model, we probed the behavioral and biochemical effects accompanying administration of antineoplastic agent doxorubicin (7.5 mg/kg) and DPDS (5 and 10 mg/kg). Anxiogenic-like behavior, motor and locomotor insufficiencies associated with doxorubicin were considerably abated by both DPDS doses with concomitant enhancement in exploratory behavior as demonstrated by reduced heat maps intensity and enhanced track plot densities. Moreover, with exception of cerebral glutathione (GSH) level, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, biochemical data demonstrated reversal of doxorubicin-mediated decline in cerebral and cerebellar antioxidant status indices and the increase in acetylcholinesterase (AChE) activity by both doses of DPDS. Also, cerebellar and cerebral lipid peroxidation, hydrogen peroxide as well as reactive oxygen and nitrogen species levels were considerably diminished in rats administered doxorubicin and DPDS. In addition, DPDS administration abated myeloperoxidase activity, tumour necrosis factor alpha and nitric oxide levels along with caspase-3 activity in doxorubicin-administered rats. Chemoprotection of doxorubicin-associated neurotoxicity by DPDS was further validated by histomorphometry and histochemical staining. Taken together, DPDS through offsetting of oxido-inflammatory stress and caspase-3 activation elicited neuroprotection in doxorubicin-treated rats.
Patients receive placebo PO QD on days 1-28 and fulvestrant as in Arm I. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
PURPOSE:To provide a massage oil containing lard, peppermint and a natural solvent at specific ratios, free from adverse effect on the skin and effective in promoting blood flow, improving the metabolism of the skin and activating the skin. CONSTITUTION:The objective massage oil is composed of (A) 65-75wt.% of lard containing preferably >=70% of oleic acid, (B) 10-15wt.% of peppermint and (C) the residual part of a natural solvent (e.g. animal milk such as cow's milk). The skin is imparted with moistness by the lard permeated into the skin and the blood flow is promoted by the peppermint. When the oil is applied to a congested part such as hemorrhoid, the blood flow can be promoted to cure the diseased part by the perspiration effect of peppermint and the massaging effect of lard. Application of the oil to nail activates the nail and improves its luster and hardness. The oil is also effective in ameliorating arthritis, etc., by applying to the joint.
The painless photodynamic therapy group underwent narrow-band light-emitting diode (LED) irradiation (630 nm; 150 J/cm2) after applying 5% 5-aminolevulinic acid#ALA#cream for 30min. A repeat treatment was administered once weekly for a maximum of 3 weeks.
Improved maternal nutritional status is hypothesized to promote good pregnancy and infant health outcomes but trial evidence supporting the commencement of nutritional supplementation before conception is sparse. The NiPPeR (Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health) multinational double-blind randomized controlled trial conducted in the United Kingdom, Singapore, and New Zealand tested a nutritional formulation containing myo-inositol, probiotics, and multiple micronutrients (intervention), compared with a standard micronutrient supplement (control), taken at preconception and throughout pregnancy. The primary outcome of gestational glycemia at 28 weeks' gestation showed no difference. However, differences in several prespecified secondary outcomes were notable. The intervention reduced the incidence of preterm delivery particularly those associated with preterm prelabor rupture of membranes, operative delivery for delayed second stage, and major postpartum hemorrhage. It may also shorten time to conception in overweight women, to that similar to nonoverweight/obese women. Importantly, the intervention associated with a reduction in the incidence of rapid infant weight gain and high body mass index at 2 years among offspring. Such evidence indicates the potential for preconception maternal nutritional interventions to have appreciable impact in shaping the long-term health of an individual and building resilience against noncommunicable chronic diseases in the future.