anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Lifestyle interventions targeting overweight individuals can produce positive "ripple" effects on untreated overweight partners in the home. Interestingly, ripple effects on partners' weight appear most pronounced when the interventions target women. Women, and mothers in particular, remain the primary "nutritional gatekeepers" of the home. Despite widespread recognition that motherhood is a powerful motivator for behavior changes, no study to date has examined the "ripple" effects of prenatal lifestyle interventions that target mothers' gestational weight gain. The primary aim of the proposed study is to determine whether lifestyle interventions to prevent excessive gestational weight gain in overweight/obese pregnant women have positive "ripple" effects on untreated partners in the home. The proposed study is ancillary to two randomized phase III clinical trials in the LIFE-moms consortium (1U01HL114377-01, PI Phelan; 3U01DK094463-03S1, PIs Pi-Sunyer and Gallagher) that are examining the efficacy of multi-component lifestyle interventions to prevent excessive gestational weight gain in a total of 650 overweight/obese women. In this ancillary study, partners' weight, home environment, and psychosocial behaviors will be assessed when their pregnant partners are \~13 weeks gestation (study entry), 35 weeks gestation and at 6 and 12 months postpartum. We hypothesize that partners of pregnant women randomized to the lifestyle intervention, relative to those of standard care, will have greater weight losses through 12-months. Secondary aims examine partner improvements in weight control behaviors, the home environment, and psychosocial parameters. This project is highly innovative, as it capitalizes on existing funded research and is the first study to examine ripple effects of multicomponent prenatal interventions. The project also has high impact, as pregnancy is a powerful motivator for behavior and environmental changes in the home; and, if positive ripple effects occur, the field of obesity treatment and prevention could move beyond focus on individual level to the often unrecognized interpersonal effects of lifestyle interventions. PUBLIC HEALTH RELEVANCE: This research project will examine whether interventions to prevent excessive gestational weight gain have positive "ripple" effects on the health of untreated partners in the home.
Intravenous infusion with electric syringe of Dexmedetomidine 0,4ug/ml. Rate 0,1ug/kg/h to 1,4ug/kg/h. Nightly infusion from 20:00 to 08:00. The drug is titrated to achieve RASS between -1 and 1. Modification of infusion rate by 0,1ug/kg/h is recommended with stabilization phase of 1 hour before another rate adjustment.
PURPOSE:To provide a hairdye composition containing a reactive dye having S-triazinyl group and containing a specific eliminable group, and capable of permanently dyeing the hair to an extent comparable with the dyeing with oxidizing dye, safely, at a low temperature and nearly neutral condition, with extremely simple process. CONSTITUTION:The objective hairdye composition can be prepared by using a reactive dye having one or more S-triazinyl groups and having an eliminable group of formula I (X is carboxylic acid residue, sulfonic acid residue, OH, etc.; n is 1 or 2) as an essential component. The reactive dye can be prepared by condensing an azo- or anthraquinone-dye having one or more monohalogeno- or dihalogeno-S-triazinyl groups with the pyridine derivative of formula II in an aqueous medium. Concrete example of the compound is the compound of formula III, etc. The composition of the present invention is dissolved or dispersed in water to obtain an aqueous solution or paste, and hair is immersed in the solution or coated with the paste to effect the dyeing of the hair.
The participants in the unguided intervention group will not receive the aforementioned feedback calls. The participants in the unguided intervention group will only receive an email reminder and text message if the participants have not completed the required session of that week on the 5th, 6th, and 7th of the same week. Technical supports are available.
Allotetraploid wheat reflects evolutionary divergence and domestication convergence in the karyotypic and phenotypic evolution, accompanied with the transformation from r- strategy to K- strategy in reproductive fitness. Allotetraploid wheat, the progenitor of hexaploidy bread wheat, has undergone 300,000 years of natural evolution and 10,000 years of domestication. The variations in karyotype and phenotype as well as fertility fitness have not been systematically linked. Here, by combining fluorescent in situ hybridization with the quantification of phenotypic and reproductive traits, we compared the karyotype, vegetative growth phenotype and reproductive fitness among synthesized, wild and domesticated accessions of allotetraploid wheat. We detected that the wild accessions showed dramatically high frequencies of homologous recombination and copy number variations of simple sequence repeats (SSR) comparing with synthetic and domesticated accessions. The phenotypic traits reflected significant differences among the populations shaped by distinct evolutionary processes. The diversity observed in wild accessions was significantly greater than that in domesticated ones, particularly in traits associated with vegetative growth and spike morphology. We found that the active pollen of domesticated accessions exhibited greater potential of germination, despite a lower rate of active pollen compared with the wild accessions, indicating a transformation in reproductive fitness strategy for pollen development in domesticated accessions compared to the wild accessions, from r-strategy to K-strategy. Our results demonstrate the condensation of karyotype and phenotype from natural wild accessions to domesticated accessions in allotetraploid wheats. Ecological strategy transformation should be seriously considered from evolution to domestication in polyploid plants, especially crops, which may provide a perspective on the adaptive evolution of polyploid plants.
Patients in the intervention group will be asked to list 2 goals for their visit. They will also be asked to complete a demographics survey and access their perceived involvement in care after their visit.
The utility model relates to a moisture retention lecithin microcapsule fiber. The moisture retention lecithin microcapsule fiber comprises a main fiber body and is characterized in that a moisture retention lecithin microcapsule layer is adhered outside the main fiber body. The moisture retention lecithin microcapsule layer is obtained by treating a moisture retention lecithin microcapsule finishing agent. In order to meet the production requirements of various products, the main fiber body is a natural fiber. The moisture retention lecithin microcapsule fiber provided by the utility model directly has the effect of moisture retention lecithin microcapsules as the moisture retention lecithin microcapsule layer is combined with the fiber; and a plus material obtained by weaving the fiber has good health care effect, and the lecithin in the plus material transfers to the skin of a human body. Most important of all, as the moisture retention lecithin microcapsule layer is directly adhered to the fiber, the using space of the moisture retention lecithin microcapsule layer can be greatly increased, and the various weaving effects of the plus material are not influenced.
A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
Despite numerous studies on the effect of each dialysis modality on mortality, the issue remains controversial. We investigated the hazard rate of mortality in patients with incident end-stage renal disease (ESRD) concerning initial dialysis modality (hemodialysis vs. peritoneal dialysis). Using a nationwide, multicenter, prospective cohort in South Korea, we studied 2207 patients, of which 1647 (74.6%) underwent hemodialysis. We employed the weighted Fine and Gray model over the follow-up period using inverse probability of treatment and censoring weighting. Landmark analysis was used for identifying the changing effect of dialysis modality on individuals who remained event-free at each landmark point. No significant difference in hazard rate was observed overall. However, the peritoneal dialysis group had a significantly higher hazard rate than the hemodialysis group among patients under 65 years after 4- and 5- year follow-up. A similar pattern was observed among those with diabetes mellitus. Landmark analysis also showed the higher hazard rate for peritoneal dialysis at 2 years for the education-others group and at 3 years for the married group. These findings may inform dialysis modality decisions, suggesting a preference for hemodialysis in young patients with diabetes, especially for follow-ups longer than 3 years.
No specific antidotes for zonisamide overdosage are available. Following a suspected recent overdose, emesis should be induced or gastric lavage performed with the usual precautions to protect the airway. General supportive care is indicated, including frequent monitoring of vital signs and close observation.

Zonisamide has a long half-life [see Clinical Pharmacology (12.3)]. Due to the low protein binding of zonisamide (40%), renal dialysis may be effective. The effectiveness of renal dialysis as a treatment of overdose has not been formally studied. A poison control center should be contacted for information on the management of ZONISADE overdosage.
FIELD: veterinary science. SUBSTANCE: invention relates to preparations that are used for prophylaxis and treatment of pathology of reproductive organs in cows. Emulsion "Endometritsit" comprising antibacterial, anti-inflammatory and accessory substances contains myotonic agent proserinum additionally. Emulsion comprises cefamezin and metronidazole as an antibacterial agents, prednisolone as an anti-inflammatory agent, and olive oil, emulsifier T-2 and distilled water as accessory substances. Emulsion comprises components showing the broad effect on uterus microflora and fungi, anti-inflammatory and myotonic agents. Emulsion exhibits high curative and prophylactic properties, its effect in uterus retains for 24 h, not less. After application of emulsion for prophylactic aim in placenta retention and difficult delivery the fertilization is 85%, and in treatment of acute and chronic endometritis the curative effect is 88.9% and 84.5%, respectively. EFFECT: valuable properties and enhanced effectiveness of emulsion. 1 tbl
Diet randomization occurs two weeks prior to the Standard of Care (SOC) diagnostic biopsy. If patient is randomized to Arm 2, they will receive Lower Carbohydrate (LC) Mediterranean Diet first. The results of the diagnostic biopsy determines how the patient will proceed on the trial. If there is a confirmed Prostate Cancer (PCa) diagnosis AND is a candidate for Active Surveillance (AS) per SOC, then patient will undergo a washout period and cross-over to the Low Fat (LF) Mediterranean Diet two weeks prior to the SOC confirmatory biopsy. A long-term follow-up (LTFU) visit will occur 3 months after the second dietary intervention has concluded. If patient does not have PCa or is not placed on AS, then they will only have the first dietary intervention and a LTFU visit 3 months after.
An oral solution containing galanthamine hydrobromide and fructose as sweetener, for the production of which 15-30% (w/v) fructose is used. Galanthamine, a tertiary alkaloid, is a selective, competitive and reversible inhibitor of acetylcholinesterase. It has been proven effective in the therapy of memory disorders, such as AlzheimerÆs disease and vascular dementia. The addition of fructose in the solution allows the reduction of the unpleasant taste of galanthamine hydrobromide when dissolved in aqueous medium. Fructose affects the sugar of the human organism in a mild and gradual manner, thus it is considered a healthy sweetener suitable for the diet of diabetics. The recommended daily dose for adults is 8 mg or 24 mg galanthamine.
The present invention relates to cream soap for removing keratin, and a production method thereof. When used to skin, the cream soap is usable irrespective of the presence of moisture. Without using a body scrub towel, by lightly scrubbing a body with the cream soap by a hand or a thin tower, it is possible to easily and conveniently remove bodily waste such as sebum and keratin from the skin. Also, the skin is smoothly maintained, and a moisturizing effect is excellent. Antibacterial and sterilizing effects are also ensured. The cream soap for removing keratin according to the present invention comprises: 43.0 to 54.0 wt% of a soap base; 33.0 to 40.0 wt% of a coagulant; 11.0 to 15.0 wt% of purified water; 1.95 to 2.50 wt% of natural substances; and 0.05 to 0.15 wt% of a Houttuynia cordata extract, a rosemary extract, a rose flower extract, a chamomile extract, and a lavender extract. The cream soap for removing keratin according to the present invention can be lightly scrubbed on a body by a hand or a thin tower without using a towel irrespective of the presence of moisture, and thus sebum, keratin, and bodily waste can be easily removed. Also, the skin is smoothed, and a moisturizing effect is excellent. In addition, when the cream soap for removing keratin according to the present invention is produced, gum is not generated. Thus, when used to skin, the cream soap is attached to the skin. Accordingly, fat is adsorbed, and it is possible to prevent a problem in which bodily waste such as sebum and keratin is not actively removed. Furthermore, a Houttuynia cordata extract, a rosemary extract, a rose flower extract, a chamomile extract, and a lavender extract having antibacterial and sterilizing effects are added, and thus excellent effects of preventing and treating acne or athlete′s foot can be provided.
The present invention relates to a novel ophthalmic preparation especially designed for computer eyesight syndromes, particularly to a computer eyesight protection ophthalmic preparation. The present invention uses glycerol for maintaining moisture in tears, and uses hydroxypropyl methyl cellulose for lubricating eyeballs and extending time of the present invention for staying on eyeballs; the present invention also contains a buffer agent and an osmotic regulator. The pH range of the present invention is 6.7 to 7.3, the osmotic pressure is 270 to 330 mOsm/kg, and the viscosity is less than 5 centipoise. The present invention can maintain natural moisture in tears, performs the function of lubrication, and effectively relieves symptoms of eye dryness, blurred vision, etc. which result from overuse of fluorescent screens (such as computers). Since the adopted material does not affect contact lenses, the present invention can be used by people wearing common glasses and contact lenses simultaneously.
This study applied machine learning for the early prediction of 30-day mortality at sepsis diagnosis time in critically ill patients. Retrospective study using data collected from the Medical Information Mart for Intensive Care IV database. The data of the patient cohort was divided on the basis of the year of hospitalization, into training (2008-2013), validation (2014-2016), and testing (2017-2019) datasets. 24,377 patients with the sepsis diagnosis time < 24 h after intensive care unit (ICU) admission were included. A gradient boosting tree-based algorithm (XGBoost) was used for training the machine learning model to predict 30-day mortality at sepsis diagnosis time in critically ill patients. Model performance was measured in both discrimination and calibration aspects. The model was interpreted using the SHapley Additive exPlanations (SHAP) module. The 30-day mortality rate of the testing dataset was 17.9%, and 39 features were selected for the machine learning model. Model performance on the testing dataset achieved an area under the receiver operating characteristic curve (AUROC) of 0.853 (95% CI 0.837-0.868) and an area under the precision-recall curves of 0.581 (95% CI 0.541-0.619). The calibration plot for the model revealed a slope of 1.03 (95% CI 0.94-1.12) and intercept of 0.14 (95% CI 0.04-0.25). The SHAP revealed the top three most significant features, namely age, increased red blood cell distribution width, and respiratory rate. Our study demonstrated the feasibility of using the interpretable machine learning model to predict mortality at sepsis diagnosis time.
Provided is a composition that is useful for treating acne, and which has been found to reduce and/or eliminate acne outbreaks or reduce the severity thereof. The composition includes mangosteen and curcumin. At least a portion of the mangosteen and curcumin can be provided in the form of extracts thereof. The composition can optionally include other components such as guggul, guggul extracts, thyme, thyme extracts, piperine, vitamin B5, vitamin B6, zinc, beta glucans, and green tea extracts. The composition can be provided as an oral administration unit such as a pill or capsule. Also provided is a method of treating acne by ingesting an effective amount of the composition described herein.
The present invention belongs to the field of antibacterial and disinfectant preparations, and relates to a povidone iodine solution and gel with enhanced stability, and a preparation method and application thereof. The povidone iodine solution includes povidone iodine, a stabilizer bag and a pH regulator bag. Specifically, the povidone iodine solution includes the following components based on parts by weight: 5-15 parts by weight of povidone iodine, 0.4-1.8 parts by weight of stabilizer bag, 0.6-1.0 part by weight of pH regulator bag and the balance purified water. Specifically, the pH value of the povidone iodine solution is 1.5-6.5. The provide iodine gel includes povidone iodine, a gel matrix, a stabilizer pack, and a pH regulator pack. Specifically, the povidone iodine gel includes 5-15 parts by weight of the povidone iodine, 0.3-1.5 parts by weight of the gel matrix, 0.4-1.8 parts by weight of the stabilizer pack, 0.6-1.0 part by weight of the pH regulator pack, and the balance of purified water; wherein the povidone iodine gel has a pH value of 1.5-6.5 and a viscosity of 400-5,000 mPa.s.
A longitudinal open-label study that will include individuals who will receive the ChAdOx1 nCoV-19 vaccine (AZD1222), in a standard 3-dose schedule with an interval of 12 weeks (first-second dose) and 24 weeks (second-thrid dose), in the vaccination campaign against SARS-CoV-2 to assess the safety, efficacy and duration of the short- and long-term humoral and cellular immune response after vaccination for COVID- 19 and compare the vaccine response between individuals who have or have not had previous SARS-Cov 2 infection. Health professionals (HS) and patients with immune-mediated inflammatory diseases (IMID) who participate in vaccination campaigns at the Cassiano Antônio Mores da University Hospital will be included. Federal University of Espírito Santo (HUCAM-UFES). It is intended to include 200 health workers and 350 patients with IMID, totaling 550 participants. Participants who have had previous SARS-CoV-2 infection confirmed by RT-PCR or positive PRNT at baseline will be considered a group exposed to COVID-19 (CovPrev) and the group without previous infection will be considered a control group (Naive). The IMID group will include patients with Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Spondyloarthritis (SA), Sjögren's Syndrome (SS), Psoriasis (Pso), Inflammatory Bowel Disease (IBD) and Vasculitis (VASC) who complete validated international classification criteria for each disease. The criteria for vaccination in the IMID group will be in accordance with the National Immunization Program of the Ministry of Health (PNI/MS). Adverse events will be recorded during the first, second and fourth week, and through weekly telephone contacts until D40. The evaluations and collection of biological samples will be carried out in 5 moments (D0, D14 and D28 after the first dose; D28 after the second dose; and D28 after thrid dose) to evaluate the efficacy and in 3 moments (D180, D360 and D540), to evaluate the duration of immunity. Neutralization tests by plaque reduction (PRNT) will be performed to detect neutralizing antibodies against COVID-19, determination of the profile of specific IgM, IgA and IgG, dosage of systemic soluble factors (chemokines, cytokines and growth factors), characterization of phenotypes of immunoregulation, immunosenescence, cell activation and exhaustion and antigen-specific stimulation of peripheral blood mononuclear cells in vitro. The study hypothesis is that vaccine-induced production of neutralizing antibodies is more effective in individuals with previous natural SARS-Cov2 infection and less in immunosuppressed individuals.
Patients receive modified FOLFOX-6 therapy comprising oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously on days 1-5. Treatment repeats every 14 days for 3 courses. Patients then undergo PET/CT scan. Patients with responsive disease (tumor metabolic activity decreased by \>= 35%) receive 3 additional courses of FOLFOX-6 therapy and undergo concurrent RT (3D-conformal or intensity-modulated) once daily, 5 days a week, for approximately 6 weeks. Patients without responsive disease (tumor metabolic activity did not decrease by 35%) cross over to Arm II during RT.
PURPOSE:To obtain a lipopolysaccharide useful as an agent for immunotherapy of tumor and adjuvant simply and efficiently, by extracting an extract obtained by cultivating a ray fungus with a nonioic surface active agent, purifying it with a molecular sieve. CONSTITUTION:A mold obtained by cultivating a ray fungus, or a bacterium related to it (e.g., Mycobacterium tuberculsis Aoyama B strain, Mycobacterium bovis BCG strain, etc.) is extracted with a nonionic surface active agent (e.g., Triton X-100, etc.). The extracted solution is purified with a molecular sieve (e.g., baio geru A-5m, etc.) to give a lipopolysaccharide. The lipopolysaccharide consists of 53-63wt% polysaccharide comprising 1 D-arabinose and 3-4 D- mannose and 37-47wt% fatty acid. The use of the nonionic surface active agent in extraction can separate the extract from side effect substance, to give the lipopolysaccharide showing strong activity.
Elderly patients (aged 65 years or older) may have increased sensitivity to LORTAB ELIXIR. In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. 

Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration. Titrate the dosage of LORTAB ELIXIR slowly in geriatric patients and follow closely for signs of central nervous system and respiratory depression [see WARNINGS]. 

Hydrocodone and acetaminophen are known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to follow renal function.
Participants will receive immunoglobulin therapy plus standard management. The first intravenous infusion of immunoglobulin must be given within 72 hours after the onset.