anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The adrenal gland is a small organ of the body. It produces very important chemicals called hormones. One of these hormones, cortisol (the stress hormone) helps the body fight diseases. The other hormone is the aldosterone helps to maintain the normal amount of salt and water in the body. The third type of hormones are the androgens or male hormones, which cause some of the changes during puberty, like the growth of body hair and pimples.

The salt wasting Congenital Adrenal Hyperplasia or CAH disease is a disease of the adrenal gland. Patients with this disease cannot make cortisol or the aldosterone. As a result, their body cannot fight diseases and cannot keep normal amounts of salt and water in the body. At the same time, the gland makes too much of the male hormones, which is bad for the body because too much male hormone slows down growth, increases the growth of body hair, and causes pimples and abnormal period in girls.

Patients with this disease have to take medications every day. However, the treatment does not work very well, because usually the patients do not have the right amount of hormone in their body. Usually the body gets too much hormone right after taking the pills. A couple of hours later the body has too little of the hormones, because in the meantime the body gets rid of the medication.The healthy adrenal gland makes the hormones throughout the day in different amounts. The patients with this disease take the medication only a couple of times a day. They take the Florinef tablet once a day and the Cortisol tablet two or three times a day. The treatment that we use today by mouth cannot copy the natural hormone productions of the adrenal gland. Because of this it does not make much of a difference in the patient's life.

We would like to improve the treatment and find out the effect of a new treatment. In this study we will try to imitate the body's normal hormone production and will give the medication via an insulin pump to see if this treatment method will decrease the male hormones in the blood. This study will help us to develop a new and better treatment for children and adolescents.
Mastitis is the most common disease of dairy cattle and can be manifested in clinical and subclinical forms. The overuse of antimicrobials in the treatment and prevention of mastitis favours antimicrobial resistance and milk can be a potential route of dissemination. This study aimed to evaluate the biological quality of bulk tank milk (BTM) and the microbiological quality and signs of mastitis of freshly milked raw milk. In addition, to evaluate antimicrobial resistance in Enterobacteriaceae and Staphylococcus spp. isolated from freshly milked raw milk. None of the farms were within the official Brazilian biological quality limits for BTM. Freshly milked raw milk with signs of clinical (CMM), subclinical (SCMM) and no signs (MFM) of mastitis were detected in 6.67%, 27.62% and 65.71% samples, respectively. Most samples of freshly milked raw milk showed acceptable microbiological quality, when evaluating the indicators total coliforms (78.10%), Escherichia coli (88.57%) and Staphylococcus aureus (100%). Klebsiella oxytoca and S. aureus were the most prevalent microorganisms in SCMM and MFM samples. Antimicrobial resistance and multidrug resistance (MDR) were observed in 65.12% and 13.95% of Enterobacteriaceae and 84.31% and 5.88% of Staphylococcus spp., respectively, isolated from both SCMM and MFM samples. Enterobacteriaceae resistant to third-generation cephalosporin (3GCR) (6.98%) and carbapenems (CRE) (6.98%) and methicillin-resistant S. aureus (MRSA) (4.88%) were observed. Antimicrobial-resistant bacteria can spread resistance genes to previously susceptible bacteria. This is a problem that affects animal, human and environmental health and should be evaluated within the one-health concept.
Participants in this arm receive information about lung screening purpose, eligibility, benefits and risks in a format that uses text with non-narrative pictures for decoration. The pictures have been extracted from the picture narratives being used Arm 1.
Participants will receive a single oral dose of placebo matching E6742 in the fasted state. Participants will then receive the same single oral dose of placebo again in the fed state after a washout interval (at least 7 days ) for the evaluation of food effect.
Congenital long QT syndrome (LQTS) is a genetic heart disorder, which may lead to life-threatening arrhythmias, especially in children. Here, we reported two children who were initially misdiagnosed with epilepsy and experienced Torsades de Pointes (TdP) cardiac electrical storm (ES). Through whole exome sequencing (WES), we identified two Potassium voltage-gated channel subfamily H member 2 (KCHN2) mutations (c.1841 C > T and c.1838 C > T) respectively in a 6-year-old boy and a 13-year-old girl. Clinical data indicated that the QT interval was significantly prolonged, the T-wave pattern of chest V5-V6 leads and limb leads were inverted. Our study suggests that patients with epilepsy, especially those refractory epilepsy with atypical features, need comprehensive evaluation of cardiovascular function. KCNH2 mutation in pore region, QT interval prolongation and T wave inversion are high risk factors for ES. For LQT2 patients with ES, Nadolol and left cardiac sympathetic denervation are indicated, sometimes with an ICD.
NEW MATERIAL:Kuwanon J of the formula. USE:An antimicrobial agent. PROCESS:A plant of the genus Morus is finely cut, defatted in an organic solvent, e.g. n-hexane or benzene, and extracted with an alcohol having lower polarity, e.g. ether or acetone, and the resultant extract is filtered. The resultant filtrate is then dried under reduced pressure to give a purplish red powder, which is then subjected to the column chromatography to separate impurities and affords a fraction rich in the kuwanon J. The fraction is then subjected to the preparative thin layer chromatography or high-speed liquid chromatography, isolated and separated to prepare the aimed kuwanon J of the formula.
PROBLEM TO BE SOLVED: To provide a deodorant which is capable of effectively removing or decreasing the malodors and offensive odors formed in the metabolism within the human and animal bodies and in toilets, stock raising ranches and other environments. SOLUTION: The hydrophilic solvent extract (or its hydrolyzate) of Bear-berry (Arctostaphylos uva-ursi (L.) Sprengel) is used as the effective component of the deodorant. The hydrophilic solvent extract is prepd. by drying the leaves of the Bear-berry at need and extracting the pulverized leaves by a hydrophilic solvent. The hydrophilic solvent used for the extraction includes water, methanol, ethanol, isopropyl alcohol, acetone or their solvent mixture, etc., for which the water or the ethanol and/or water/ ethanol solvent mixture is more preferable as this solvent is not of a problem in case of remaining in order for use particularly for medical purposes or as food. Org. acid or sugar content may be previously added to the solvent. In such a case, the extraction of the component is more effectively executed.  Citric acid, malic acid, acetic acid and ascorbic acid are preferable as the org. acid. The amt. of the addition thereof is adequately 0.05 to 2 wt.% of the weight of the solvent and is preferably so adjusted as to be kept within a range of pH3.0 to 5.0. Fructose, glucose, sucrose, maltose, etc., are usable as the sugar.
Schizophrenia is a chronic illness characterized by disturbances in cognition, affect and behavior, all of which have a bizarre aspect. It is a common disorder, with a prevalence of about 1%. It has an equal prevalence in both sexes although men manifest their symptoms earlier than women. \[1, 2\] Individuals with schizophrenia have a 2-3 fold increase in mortality rate compared to the general population. This rate had increased in recent decades. \[3, 4\] Most patients are incapable of maintaining their jobs and relationships. About half attempt suicide, and about 10% succeed. Most suicides occur early in the course of the illness. \[1\] Optimal management of schizophrenia requires psychological, social, and occupational therapies. \[2\] There are a lot of antipsychotic drugs which are necessary for treatment. Risperidone, an atypical antipsychotic, has been approved by the Food and Drug Administration for the treatment of schizophrenia in the adolescent population in the adolescent population. \[5\] Although atypical antipsychotic agents have improved outcomes in schizophrenia, their clinical potential remains limited by patients' nonadherence to medication. \[6\] Some of the patients with schizophrenia do not respond completely to treatment and only experience a partial improvement and remain functionally impaired. While medication has been found to be effective for the treatment of "positive" symptoms of the disease, treatment of the "negative symptoms" of schizophrenia (including lack of energy, motivation, and emotions) has historically not been very successful. \[4, 5\] MS14 is an Iranian herbal-marine compound that has been patented by invention and patent registration office of Islamic Republic of Iran (no: 29350) and classified as equivalent to food with no observable adverse effect level (NOAEL). \[8, 9\] According to analytic data this compound contains many inorganic salts or complexes and also trace elements such as bromine (Br), strontium (Sr), vanadium (V), titanium (Ti), nickel (Ni) and zinc (Zn). \[10\] Safety of MS14 has been confirmed by sub-acute toxicity studies in rats (clinical, histopathological, hematological and biochemical). \[8\] A study of MS14 in experimental allergic encephalomyelitis (EAE) model has shown that oral treatment of the EAE mice with MS14 not only halts the progression of the disease but also attenuates the inflammation in CNS indicating that this herbal-marine compound has anti-inflammatory effects \[11\].

Overall, alleviation of clinical and neurological symptoms in EAE mice by MS14 explained the beneficial effects of traditionally used MS14 in MS patients, an effect which could also be investigated in other groups of psychological and neurological diseases. Additionally, there are anecdotal but unconfirmed reports for the effectiveness of MS14 in patients with schizophrenia. In this regard, we have decided to perform a randomized placebo-controlled study on the effect of MS14 on schizophrenia, to assess the safety and efficacy of this compound.
Participants randomly assigned to control group will be instructed to maintain their normal life habits with respect to physical activity and diet. During the 5 months of intervention participants from this group will receive at least one call from the researchers to be interested in their health status and inform them about the next evaluation appointment, as well as, an objectively evaluation of the main behaviours in the middle of intervention. Investigators will inform about the relevance of attending the full process and respecting the condition and rule as control. Participants from the control group will be freely offered the possibility to get involve in a similar intervention protocol at the end of the study in order to benefit from the potential positive effect of exercise.
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl . Exemplary molecules comprise a sequence of formulae wherein the substituents are as defined in the specification. The invention furthercomprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
Patients receive standard of care ADT comprising one of the following at the discretion of the treating physician: leuprolide acetate, goserelin acetate, histrelin acetate, triptorelin, or degarelix SC or IM for 12 months in the absence of disease progression or unacceptable toxicity. Patients may also choose to undergo surgical castration as an alternative form of ADT.
The invention aims to provide a method for processing and cultivation of artificially cultivated tussah cordyceps militaris taken as traditional Chinese medicinal materials. The method includes: adopting live and healthy tussah pupas, artificially inoculating cordyceps militaris at the temperature ranging from 15 DEG C to 25 DEG C, cultivating for 45-60 days, and adopting blue light (60-100 lux) and white light (350-400 lux) for alternately irradiating for 8-10 hours, so that the tussah cordyceps militaris with stable and controllable active ingredients can be cultivated. In addition, processing of the tussah cordyceps militaris (both pupas and grass) taken as traditional Chinese medicinal materials is carried out by drying and smashing at the temperature not higher than 60 DEG C to guarantee activity of the active ingredients of the tussah cordyceps militaris taken as traditional Chinese medicinal materials to the greatest extent. A characteristic detection method for the tussah cordyceps militaris taken as traditional Chinese medicinal materials includes: adopting a high performance liquid and mass spectrum detection system and reference substances to carry out qualitative detection and ingredient identification of the tussah cordyceps militaris taken as traditional Chinese medicinal materials, adopting a fingerprint characteristic spectrum for fingerprint detection, wherein relative retention time of five characteristic spectrum peaks is within +/-5%. According to identification, fingerprint ingredients include uridine, tyrosine, adenosine, cordycepin and N-(2) hydroxyl adenosine sequentially from a peak 1 to a peak 5. The tussah cordyceps militaris taken as traditional Chinese medicinal materials can be clinically used for treating cold.
Toxoplasma gondii is an intracellular protozoan parasite that causes neuroinflammation in the brain and a constant need for peripheral leukocyte migration. Matrix metalloproteinase 9 (MMP-9) can play a major role in this neuroinflammation and be implicated in some neurological disorders, such as migraines. Therefore, the genetic polymorphism evaluation of MMP-9 in migraine patients with T. gondii infection was performed. One hundred fourteen migraine patients and 114 healthy controls were evaluated for the presence of anti-Toxoplasma IgG antibodies. Seventy-two migraine patients and 40 healthy controls were randomly selected for assessment of the MMP 9-1562C/T genetic polymorphism. In the preliminary examination, 61 (53.5%) migraine patients and 43 (37.3%) healthy controls were positive for IgG antibodies, with a significant association between T. gondii seropositivity and migraine (OR = 1.90; 95% CI = 1.21-3.223; P = 0.012). Genetic distribution for the polymorphism was not in Hardy-Weinberg equilibrium in cases but showed no significant variation in control groups (P = 0.03 and P = 0.180, respectively). A significant preponderance of the CT + TT genotype was found in migraine subjects compared to controls (P = 0.042) (OR, 1.77, CI, 1.013-2.229). The homozygote muted allele TT had a higher rate in migraine patients (6.9%). There were significant differences in CT + TT genotype between T. gondii positive and negative migraine patients (P = 0.024), but T allele frequencies had no significant variation (OR 1.7 CI, 1.084-2.44 and 0.42 CI, 0.044-3.97, respectively). In conclusion, the results may provide the first evidence for the involvement of the MMP-9 gene polymorphism in the mechanism of migraine pathology following Toxoplasma infection.
The invention relates to the field of medicine preparations, in particular to an enteric solid preparation containing lycopene or resveratrol or melatonin and a preparation method of the enteric solid preparation. The enteric solid preparation is prepared from an active ingredient resveratrol, a water-soluble and/or enteric carrier adjuvant and other pharmaceutic adjuvants. The water-soluble carrier adjuvant can serve as a water-soluble solid dispersion carrier. The enteric carrier adjuvant is an enteric polymer and can serve as an enteric solid dispersion carrier or enteric coating material. The enteric solid preparation containing resveratrol has good solubility in the intestinal tract, medicine is fast dissolved and released in the intestinal tract, and therefore absorption of resveratrol is increased, and the bioavailability of the enteric solid preparation is improved. The solid dispersion composition containing resveratrol can be suitable for the application and industrial production of tablets, granules, pellets, capsules, enteric capsules, enteric coating tablets, enteric coating pellets, enteric coating granules and other oral dosage forms.
Critically ill patients undergoing emergent endotracheal intubation are at risk for oxygen desaturation in a variety of acute care settings. Such complication could arise from patient, operator, or procedure related factors. Evidence suggests that rapid sequence intubation (RSI) improves first-pass success and reduces complications in the critically ill. Nonetheless, the procedure is not without risks. In fact, emergency intubation is associated a reported oxygen desaturation rate of 10.9% - 33.5%. High quality pre-oxygenation has been shown to prolong time to desaturation during emergency airway management. Despite advances preoxygenation techniques, a significant number of patients undergoing emergency intubation still experience desaturation. Most of the time this is transient and easily reversible. Occasionally however, desaturation becomes critical and may result in devastating complications such as dysrhythmias or cardiopulmonary arrest.

The brain consumes a significant amount of energy and is exquisitely sensitive to hypoxia and hypoperfusion. Hypoxic brain injury occurs whenever oxygen delivery to the brain is compromised. The role of secondary brain insults including hypoxia and hypotension, in traumatic brain injury (TBI) is well established. Previous literature has demonstrated that a single event of hypoxemia in a head-injured patient substantially increases morbidity and mortality. This has resulted in airway management being a cornerstone in the care of unconscious TBI patients, to ensure adequate oxygen delivery to the injured brain. However, the significance and clinical sequalae of hypoxia during emergency intubation in critically ill, non-trauma patients is not known. Therefore, the aim of this study is to evaluate neurologic function post-intubation of critically ill, non-trauma patients.
The invention relates to a traditional Chinese medicine rectal suppository with functions of resisting bacteria, diminishing inflammation and relieving itching and a preparation method thereof. The rectal suppository is prepared from the following raw materials in parts by mass: 70-80 parts of common sage herb, 1-3 parts of honeysuckle flower, 1-12 parts of radix scutellariae, 1-6 parts of fructus cnidii, 1-5 parts of coptis root, 1-6 parts of Fructus Forsythiae, 1-8 parts of phellodendron bark, 1-6 parts of peppermint oil, 1-4 parts of borneol, 1-7 parts of camphor oil, 1-6 parts of eucalyptus oil and 1-6 parts of pepper. The preparation method comprises the following steps: preparing non-oily pharmaceutical components in the raw materials, soaking, decocting, filtering and carrying out evaporative concentration to obtain paste; and respectively adding the paste and oily components into a substrate to prepare the double-layer suppository. The suppository has the functions of resisting bacteria and diminishing inflammation, has the stimulation function on partial skin, and can promote partial blood circulation. When being applied externally or partially, the suppository has the functions of promoting the subsidence of swelling, diminishing inflammation and relieving paints, and also has the effect of relieving itching. The suppository is directly inserted into the anus and used for treating hemorrhoids, anus gall, perianal eczema, prostatitis, colpitis, cervicitis, pruritus vulvae, simple lumbago and other symptoms.
220 older adults with symptomatic knee OA will attend a single research clinic visit (one of four different types of study visits) with a study clinician. The investigators will video record the visits and measure participant heart rate and skin conductance during the visit. Participants will complete baseline questionnaires immediately prior to the study visit. All participants will receive diclofenac gel (a topical over-the-counter non-steroidal anti-inflammatory drug \[NSAID\]), a guideline recommended treatment for knee OA-related pain at the end of the first study visit. Participants will identify an "index" knee (worst pain, right or left) that they will treat and follow during the study. Between study visit 1 and the 8-week follow-up visit, participants will receive an every other week text message asking them to report on pain and diclofenac use to better understand changes in pain over time. Final questionnaires will be completed at the second study visit at week 8.
Hypersensitivity reactions, some fatal or life-threatening, have also occurred. Some of these reactions have included clinical features of multiorgan failure/dysfunction, including hepatic abnormalities and evidence of disseminated intravascular coagulation. It is important to note that early manifestations of hypersensitivity (e.g., fever, lymphadenopathy) may be present even though a rash is not evident. If such signs or symptoms are present, the patient should be evaluated immediately. LAMICTAL should be discontinued if an alternative etiology for the signs or symptoms cannot be established.

Prior to initiation of treatment with LAMICTAL, the patient should be instructed that a rash or other signs or symptoms of hypersensitivity (e.g., fever, lymphadenopathy) may herald a serious medical event and that the patient should report any such occurrence to a physician immediately.
Adult patients with T1DM or T2DM without any signs of diabetic retinopathy, indicated for ocular surgical procedure from other reasons as standard of care. Blood samples and samples of intraocular fluids will bee taken during the ocular surgery.
LIORESAL INTRATHECAL (baclofen injection) is a muscle relaxant and antispastic. Its chemical name is 4-amino-3-(4-chlorophenyl) butanoic acid, and its structural formula is:

Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform.

LIORESAL INTRATHECAL is a sterile, pyrogen-free, isotonic solution free of antioxidants, preservatives or other potentially neurotoxic additives indicated only for intrathecal administration. The drug is stable in solution at 37° C and compatible with CSF. Each milliliter of LIORESAL INTRATHECAL contains baclofen U. S. P. 50 mcg, 500 mcg or 2000 mcg and sodium chloride 9 mg in Water for Injection; pH range is 5.0 - 7.0. Each ampule is intended for SINGLE USE ONLY. Discard any unused portion. DO NOT AUTOCLAVE.