anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patellar tendinopathy is one of the most common causes of anterior knee pain, particularly common in sports that required repeated jumping and landing, such as volleyball and basketball. Patellar tendinopathy clinically presents as anterior knee pain and localized tenderness at the patellar tendon. To evaluate the severity of symptoms of patellar tendinopathy, the VISA-P (Victorian institution of sports assessment- patellar tendon) questionnaire is an easily self-administered, well-validated assessment tool and commonly used across several countries. In the long term, athletes would land with knee avoidance landing patterns and transfer the load to the hip joint, which caused the further hip-related injury. Lower extremities eccentric contraction exercise has been proven the most beneficial treatment of patellar tendinopathy. However, the course of treatment needs to last for three to six months. For athletes who are still in season, it's difficult to get the immediate effect. A newly developed biomechanical taping, dynamic tape, considered to be beneficial for load absorption during muscle eccentric contraction during landing and further normalized the lower extremities load contribution by its viscoelasticity property. However, no past research has confirmed this effect.

Therefore, the aims of this study are to translate the English VISA-P questionnaire to Chinese and to study the reliability and validity of the Chinese version of the VISA-P. In the next part of the study, the investigators investigate the different landing biomechanics between individuals with and without patellar tendinopathy and establish the reliability of different landing tasks, and further explore whether the dynamic tape alters landing biomechanics in volleyball players. Methods: The first part of the study will include 15 subjects with the symptoms of patellar tendinopathy and 15 healthy subjects to fill out the translated questionnaire. In the second part of the study will include 15 volleyball players with the symptoms of patellar tendinopathy and 15 healthy controls. To compare the landing biomechanics between two groups, all subjects will conduct three landing tasks and the kinematics and kinetics of lower extremities、loading rate of vertical ground force and patellar tendon force will be recorded. In the third part of the study, the investigators will recruit 50 volleyball players with the symptoms of patellar tendinopathy and randomly assign to two groups, the dynamic tape, and sham tape. After taping, subjects will conduct three landing tasks, and the landing biomechanics will be recorded. Statistical analysis: Intra-class correlation, Pearson's correlation, and Mann-Whitney test will be used to analyze the test-retest reliability, concurrent validity, and construct validity of the Chinese version VISA-P. Repeated measures MANOVA will be used to analyze the interaction of landing biomechanics in three landing tasks between patellar tendinopathy group and healthy control, and further, analyze the interaction in three landing tasks between the dynamic tape and sham tape group in landing biomechanics parameters. Alpha level= 0.05
PROBLEM TO BE SOLVED: To obtain a glycyrrhizin oral preparation capable of importing glycyrrhizin in the oral preparation to blood without degradation in digestive tract by allowing the release of the glycyrrhizin or a salt thereof and an absorption promoter from the oral preparation to be carried out in a dissolved state at the bottom of the digestive tract. SOLUTION: This glycyrrhizin oral preparation is the one obtained by coating glycyrrhizins as a principal ingredient, and an absorption promoter with an enteric coating material. The absorption promoter is a middle chain fatty acid, e.g. capric acid or an alkali metal salt thereof, especially capric acid or sodium caprate, and polyethylene glycol, propylene glycol, distilled water, etc., are used as a solubilizing agent. The formulating mol ratio of the glycyrrhizins as the principal ingredient to the absorption promoter is (20:1) to (1:20), and the preferable preparation comprises 5-30wt.% glycyrrhizin, 5-30wt.% capric acid or the salt thereof, 20-50wt.% polyethylene glycol, 0-10wt.% propylene glycol, 0-10wt.% distilled water and 0-3wt.% caustic soda to provide 100wt.%. The enteric coating material is carboxymethyl ethyl cellulose, an azo polymer, etc.
Postural control ability may be damaged after ankle sprains. Poor postural control ability is the risk factors of the ankle sprain, forming a vicious circle of recurrent sprains. Proper and early assessment is the key to breaking down the circle. Smartphones have been utilized in the medical field. With built-in sensors, utilizing smartphones as assessment tools can provide quantitative data of postural control performance. This study aims to verify the training effect of smartphone-based training for CAI subjects.

CAI subjects were recruited and randomly assigned to App training group, Home training group and control group, receiving 6 weeks of intervention. Pre-test was conducted before the intervention, and the post-test was conducted after the 6-week intervention. The follow up assessment was conducted 4 weeks after the post-test.
The invention discloses a solid preparation for arenaria kansuensis maxim. The invention is manufactured by mixing the extract of the arenaria mansuensis maxim as a main material along with honey, excipient and water as auxiliary material. The arenaria kansuensis maxim is one of the Gansu sandwort or ovivalvule sandwort. Meanwhile, the invention also discloses a method for manufacturing the solid preparation. After being strictly tested and tried out, the weight percentage of proper compositions of the solid preparation and an effective technological process are obtained. The weight percentage is as following: (1)30 to 35 percent of the extract of the arenaria mansuensis maxim (a dissolvable solid is more than 23 percent); (2) 1 to 4 percent of the honey; (3) 10 to 50 percent of the excipient and (4) the rest is the water. Due to the weight percentage of the proper compositions and the effective technological process obtained from the strict test and the try-out, the solid preparation with the nutrition needed by the human body can be manufactured. The solid preparation of nutrition can nourish bodies, strengthen immune system, suppress cancer cells and cure diseases. In addition, the solid preparation is the product which has good health-care effect and no side effect.
The invention belongs to the field of traditional Chinese medicine composition preparation technology and relates to a composition for eliminating muscle and bone pains. The composition is prepared by scientific processing and mixing of raw materials which are natural plants. The raw materials comprise, by weight, 5-10 parts of cortex pseudolaricis, 1-3 parts of radix sophorae flavescentis, 5-10 parts of radix stemonae, 5-10 parts of cortex phellodendri, 5-10 parts of evodia lepta merr, 5-10 parts of sanguisorba officinalis, 5-10 parts of eucalyptus citriodora, 5-10 parts of urtica fissa E. pritz., 5-10 parts of leek root, 5-10 parts of dandelion, 5-10 parts of orange peel, 5-10 parts of Chinese prickly ash, 5-10 parts of folium artemisiae argyi, 5-10 parts of Chinaberry seed, 0.1-0.2 part of squalene, 3-5 parts of pine bark and 5-10 parts of maple leaves. A preparation method comprises the following steps: washing the fresh natural plant materials, naturally airing, dicing, putting into a microwave, controlling temperature to 60-70 DEG C and drying, respectively cutting up each raw material into particles with particle size of 2-5 millimeters by a chopper, weighing each powdery raw material according to the above ratio, adding squalene, and uniformly stirring and mixing to obtain the composition. The formula is scientific and reasonable; the raw materials are rich and easily available; the preparation process is simple; and the product has an obvious effect of enhancing physical strength and is drinking environment-friendly.
PURPOSE:A dentifrice composition, capable of exhibiting a powerful removing effect on tobacco tar even in the presence of multivalent cations with high safety, and comprising phytic acid or a derivative thereof and an organic acid or a salt thereof. CONSTITUTION:A dentifrice composition comprising (A) phytic acid (myo-inositol hexaphosphate) or a derivative thereof and (B) an organic acid, e.g. citric or tartric acid, or a salt thereof. The amounts of (A) and (B) are 0.1-50wt% calculated as the phytic acid and 0.1-20wt%, respectively. Although effective in removing tobbcco tar attached to a tooth or artificial denture, the acid (A) loses the effect greatly in the presence of multivalent cations, e.g. Ca or Mg, incorporated therein as a polishing agent. The organic acid (B) eliminates the disadvantage described above.
A pharmaceutical composition comprising an active pharmaceutical agent and an excipient combination which acts as a diluent, disintegrant, anti-adherent or lubricant, wherein the pharmaceutical composition minimises adverse reactions to the components of the composition. In a preferred embodiment the excipient combination is rice starch and cellulose or a derivative thereof. Preferably the rice starch is pregelatinised or in the form of grains and the cellulose is crystalline or powdered. In some embodiments the composition is in the form of tablets or capsules. Preferably the compositions do not contain dyes, inks or colourings and are free from sulphites, benzoates and parabens. Carriers and drug delivery systems for the composition are also disclosed.
Women in the preconception, pregnant, or postpartum period are susceptible to weight stigma, particularly due to the risk of excess weight gain during the reproductive life period and the negative effects of stigma on the health of both the mother and the child. Identifying the drivers and facilitators of weight stigma will help guide focused weight stigma prevention interventions. This systematic review aimed to identify the drivers and facilitators of weight stigma among preconception, pregnant, and postpartum women. In May 2022, Medline, Embase, PsycINFO, and the Maternity and Infant Care Database were searched for peer-reviewed articles published since 2010 using search terms weight AND stigma AND preconception, OR pregnant, OR postpartum. Of the 1724 articles identified, 34 fulfilled the inclusion criteria and were included in a narrative synthesis. Women reported facing insensitive language, misconceptions about obesity across all settings, and inappropriate media representation. The unavailability of appropriate equipment at facilities was reported by both women and health professionals. Our findings indicate that a rigorous effort by all stakeholders is necessary to promote regulatory, legal, and educational initiatives designed to reduce weight stigma and discrimination against women in the reproductive period.
PROBLEM TO BE SOLVED: To obtain a lacrimation accelerating agent capable of accelerating lacrimation and useful as a prophylactic or therapeutic agent for diseases caused by dry eye, etc., by including a chymase inhibitor therein. SOLUTION: This accelerating agent comprises a chymase inhibitor as an active ingredient. The chymase inhibitor is preferably a human chymase inhibitor. The accelerating agent is an dosage form for administering to a local part of an eye and preferably used as a prophylactic or therapeutic agent for dry eye. Chymostatin, a compound, etc., of the formula (R is an alkyl or the like; A is naphthyl or the like; R' is phenyl or the like; R" is H or methyl; Z is an electrically negative group such as O, N or S) is used as a substance having chymase inhibiting action.  The accelerating agent is preferably administered in a dose of 10-500 mg/a time to an adult in the case of oral administration and preferably administered in a dose of 1-150 mg/a time to an adult in the case of injection, and when the agent is locally used, an eye lotion prepared in a concentration of 0.01 to 0.5 w/v% is preferably applied to eyes in a daily dose of 20-50 μL/a time 5 to 6 times.
INTRODUCTION: Community engagement and participatory research are widely used and considered important for ethical health research and interventions. Based on calls to unpack their complexity and observed biases in their favour, we conducted a realist review with a focus on non-communicable disease prevention. The aim was to generate an understanding of how and why engagement or participatory practices enhance or hinder the benefits of non-communicable disease research and interventions in low- and middle-income countries.
METHODS: We retroductively formulated theories based on existing literature and realist interviews. After initial searches, preliminary theories and a search strategy were developed. We searched three databases and screened records with a focus on theoretical and empirical relevance. Insights about contexts, strategies, mechanisms and outcomes were extracted and synthesised into six theories. Five realist interviews were conducted to complement literature-based theorising. The final synthesis included 17 quality-appraised articles describing 15 studies.
RESULTS: We developed six theories explaining how community engagement or participatory research practices either enhance or hinder the benefits of non-communicable disease research or interventions. Benefit-enhancing mechanisms include community members' agency being realised, a shared understanding of the benefits of health promotion, communities feeling empowered, and community members feeling solidarity and unity. Benefit-hindering mechanisms include community members' agency remaining unrealised and participation being driven by financial motives or reputational expectations.
CONCLUSION: Our review challenges assumptions about community engagement and participatory research being solely beneficial in the context of non-communicable disease prevention in low- and middle-income countries. We present both helpful and harmful pathways through which health and research outcomes are affected. Our practical recommendations relate to maximising benefits and minimising harm by addressing institutional inflexibility and researcher capabilities, managing expectations on research, promoting solidarity in solving public health challenges and sharing decision-making power.
Seventh day Adventist adults recruited from the USA and Canada. Approximately 65% female and 35% male. Composed of participants with different dietary patterns and a wide variation in egg and meat intake ranging from non-consumptive to daily consumption.
In 2010, the number of children with type 1 diabetes in France is estimated at 12,000 with 60% of them aged 12 to 17 years. Compliance is a major issue during adolescence. Mobile text message is one of the strategies to enhance adherence. The main aim of this study is to assess HbA1c reduction after a 6 month SMS support among adolescents with poorly controlled type 1 diabetes. Adherence and quality of life will also be assessed at the end of the trial. This study is a prospective randomized monocentric trial. Sixty adolescents with type 1 diabetes and HbA1c equal or higher than 8.5 % will be randomized according to the method of Zelen in two groups : standard treatment versus standard treatment plus support by SMS. The patients will receive one SMS before each injection of insulin.
The study's intervention is a parenting/caregiver training program that includes 1-month of weekly in-person sessions plus multi-media interactive text messaging. The weekly 1-hour-in-person sessions will be coupled with four interactive messages per week for a period of 4 weeks total, followed by "booster" text messages after completing the 4-week program.
The present invention relates to an antioxidant, skin whitening, and moisturizing cosmetic composition containing active ingredients of Sarcodon aspratus (Berk.) S. Ito, Chrysanthemum, and Magnolia complex extracts using Cyclodextrin Glucanotransferase (CGTase) and a production method thereof. The active ingredients of Sarcodon aspratus (Berk.) S. Ito, Chrysanthemum, and Magnolia complex extracts using Cyclodextrin Glucanotransferase (CGTase) are contained in 0.01 to 20.0 wt% with respect to the total weight of the cosmetic composition. The antioxidant, skin whitening, and moisturizing cosmetic composition of the present invention is safe for the skin, and exhibits excellent melanin production inhibition and antioxidant activity due to the synergistic action of enzyme-induced Sarcodon aspratus (Berk.) S. Ito, Chrysanthemum, and Magnolia complex components, thereby exhibiting excellent effects in skin whitening, wrinkle alleviation, elasticity enhancement, and moisturizing.
OBJECTIVES: Critically ill patients with severe pancreatitis exhibit substantial muscle wasting, which limits in-hospital and post-hospital outcomes. Survivors of critical illness undergo extensive recovery processes. Previous studies have explored pancreatic function, quality of life, and costs post-hospitalization for AP patients, but none have comprehensively quantified muscle loss and recovery post-discharge. By applying an AI-based automated segmentation tool, we aimed to quantify muscle mass recovery in ICU patients after discharge.
MATERIALS: Muscle segmentation was performed on 22 patients, with a minimum of three measurements taken during hospitalization and one clinically indicated examination after hospital discharge. Changes in psoas muscle area (PMA) between admission, discharge and follow up were calculated. T-Test was performed to identify significant differences between patients able and not able to recover their muscle mass.
RESULTS: Monitoring PMA shows muscle loss during and gain after hospitalization: The mean PMA at the first scan before or at ICU admission (TP1) was 17.08 cm², at the last scan before discharge (TP2), mean PMA was 9.61 cm². The percentage change in PMA between TP1 and TP2 ranged from - 85.42% to -2.89%, with a mean change of -40.18%. The maximum muscle decay observed during the stay was - 50.61%. After a mean follow-up period of 438.73 days most patients (81%) were able to increase their muscle mass. Compared to muscle status at TP1, only 27% of patients exhibited full recovery, with the majority still presenting a deficit of 31.96%.
CONCLUSION: Muscle recovery in ICU patients suffering from severe AP is highly variable, with only about one third of patients recovering to their initial physical status. Opportunistic screening of post-ICU patient recovery using clinically indicated imaging and AI-based segmentation tools enables precise quantification of patients' muscle status and can be employed to identify individuals who fail to recover and would benefit from secondary rehabilitation. Understanding the dynamics of muscle atrophy may improve prognosis and support personalized patient care.
While cystic fibrosis (CF) is most common in people of European ancestry, it can occur in individuals of any ethnicity. The predicted median life expectancy age for patients with CF is 47.7 years compared to 78.8 years in the general U.S. population. Exercise intolerance, evaluated as a reduction in exercise capacity (VO2 peak), has been shown to predict mortality in patients with CF independent of lung function. A critical barrier to improving exercise tolerance in CF is the lack of knowledge regarding the different physiological mechanisms which contribute to decreased exercise capacity. The present investigation will not only evaluate the impact that sildenafil has on clinically relevant and patient oriented outcomes, it will also provide mechanistic insight.

Phosphodiesterase type 5 (PDE5) inhibitors reduce inflammation, improve vascular health, increase microvascular O2 delivery and improve skeletal muscle function. Accordingly, the central hypothesis of the study is that treatment with the PDE5 inhibitor, sildenafil, can improve exercise capacity, vascular and cardiac function, and overall quality of life, all of which may contribute to improvement in exercise tolerance in people with CF
Therapeutic exercise program supervised by a physiotherapist. 2 days/week, duration 1h, in the Cardiac Rehabilitation ward.
Nonpharmacological methods are used in the management of pain and kinesiophobia following total knee arthroplasty. The aim of this double-blind randomized controlled trial was to examine the effect of foot reflexology on pain and kinesiophobia in patients following total knee arthroplasty. A total of 40 patients (20 in the control group and 20 in the intervention group) were randomly assigned to either of two groups for the study. The intervention group was exposed to foot reflexology. Postoperative Visual Analog Scale scores decreased faster in the intervention group compared to the control group (F = 80.417; p < .001; η2 = 0.685). The Western Ontario and McMaster Universities Osteoarthritis Index scores decreased in the intervention group over time, while they increased in the control group (p < .05). While a gradual increase was observed in the Tampa Scale for Kinesiophobia scores in the control group, there was a decrease in the intervention group (F = 84.860; p < .001; η2 = 0.696). The amount of analgesics used was lower in the intervention group (p < .05). Foot reflexology can be applied as an effective and safe method to manage pain and kinesiophobia in total knee arthroplasty patients.
Sysmex DI-60 enumerates and classifies leukocytes. Limited research has evaluated the performance of Sysmex DI-60 in abnormal samples, and most focused on leukopenic samples. We evaluate the efficacy of DI-60 in determining white blood cell (WBC) differentials in normal and abnormal samples in different WBC count. Peripheral blood smears (n = 166) were categorised into normal control and disease groups, and further divided into moderate and severe leucocytosis, mild leucocytosis, normal, mild leukopenia, and moderate and severe leukopenia groups based on WBC count. DI-60 preclassification and verification and manual counting results were assessed using Bland-Altman and Passing-Bablok regression analyses. The Kappa test compared the concordance in the abnormal cell detection between DI-60 and manual counting. DI-60 exhibited notable overall sensitivity and specificity for all cells, except basophils. The correlation between the DI-60 preclassification and manual counting was high for segmented neutrophils, band neutrophils, lymphocytes, and blasts, and improved for all cell classes after verification. The mean difference between DI-60 and manual counting for all cell classes was significantly high in moderate and severe leucocytosis (WBC > 30.0 × 109/L) and moderate and severe leukopenia (WBC < 1.5 × 109/L) groups. For blast cells, immature granulocytes, and atypical lymphocytes, the DI-60 verification results were similar to the manual counting results. Plasma cells showed poor agreement. In conclusion, DI-60 demonstrates consistent and reliable analysis of WBC differentials within the range of 1.5-30.0 × 109. Manual counting was indispensable in examining moderate and severe leucocytosis samples, moderate and severe leukopenia samples, and in enumerating of monocytes and plasma cells.
Patients undergo MRI or CT at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.