anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: High-flow nasal oxygenation is reported to prolong duration of apnea while maintaining adequate oxygen saturation with the mouth closed. Also, buccal oxygenation is known to have similar effects in obese adults. We compared the effect of these two methods on prolongation of acceptable apnea time in pediatric patients with their mouth open.
METHODS: Thirty-eight patients, aged 0-10 years were randomly allocated to either the high-flow nasal oxygenation group (n = 17) or the buccal oxygenation group (n = 21). After induction of anesthesia including neuromuscular blockade, manual ventilation was initiated until the expiratory oxygen concentration reached 90%. Subsequently, ventilation was paused, and the patient's head was extended, and mouth was opened. The HFNO group received 2 L·min-1·kg-1 of oxygen, and the BO group received 0.5 L·min-1·kg-1 of oxygen. We set a target apnea time according to previous literature. When the apnea time reached the target, we defined the case as "success" in prolongation of safe apnea time and resumed ventilation. When the pulse oximetry decreased to 92% before the target apnea time, it was recorded as "failure" and rescue ventilation was given.
RESULTS: The success rate of safe apnea prolongation was 100% in the high-flow nasal oxygenation group compared to 76% in the buccal oxygenation group (p = .04). Oxygen reserve index, end-tidal or transcutaneous carbon dioxide partial pressure, and pulse oximetry did not differ between groups.
CONCLUSION: High-flow nasal oxygenation is effective in maintaining appropriate arterial oxygen saturation during apnea even in children with their mouth open and is superior to buccal oxygenation. Buccal oxygenation may be a good alternative when high-flow nasal oxygenation is not available.
It's one of the restorative groups with LA (Local Anesthesia).An aerator and micromotor were used as cavity preparation in this group. A Tofflemire matrix retainer and 0.05 mm thick matrix band (Hahnenkratt, Königsbach-Stein, Germany) were used in groups with a two-surface cavity.
PROBLEM TO BE SOLVED: To provide a composition containing a plurality of peptides for preventing or treating grass pollen allergy.SOLUTION: Grass pollen allergens are typically classified into a plurality of groups. Most of Oryza sativa L. species express at least one kind of pollen allergens in each group. The specific peptide fragments derived from the main allergen in the pollen of grass species are particularly useful for desensitizing an individual against these allergens. A vaccine is formulated using the combination of a plurality of the peptides which are targeted to different MHC class II molecules. The vaccine is composed of the combination of specific peptides having wide utility to an individual with grass pollen allergy. A peptide is selected as an MHC class II-binding T cell epitope by using in silico analysis which predicts a peptide-MHC interaction, and MHC class II binding assay.
Colorectal cancer (CRC) is the third most common cancer worldwide. Although the overall incidence of CRC has been decreasing over the past 40 y, early-onset colorectal cancer (EOCRC), which is defined as a CRC diagnosis in patients aged >50 y has increased. In this Perspective, we highlight and summarize the association between diet quality and excess adiposity, and EOCRC. We also explore chronic psychosocial stress (CPS), a less investigated modifiable risk factor, and EOCRC. We were able to show that a poor-quality diet, characterized by a high intake of sugary beverages and a Western diet pattern (high intake of red and processed meats, refined grains, and foods with added sugars) can promote risk factors associated with EOCRC development, such as an imbalance in the composition and function of the gut microbiome, presence of chronic inflammation, and insulin resistance. Excess adiposity, particularly obesity onset in early adulthood, is a likely contributor of EOCRC. Although the research is sparse examining CPS and CRC/EOCRC, we describe likely pathways linking CPS to tumorigenesis. Although additional research is needed to understand what factors are driving the uptick in EOCRC, managing body weight, improving diet quality, and mitigating psychosocial stress, may play an important role in reducing an individual's risk of EOCRC.
BTX-A will be reconstituted as directed by the manufacturer. 2.5 mL of diluent (0.9% Saline) per 100 U vial will be used to reconstitute the solution while swirling. This creates a solution with a concentration of 4 U/0.1 mL. Patients will be seated and all usual precautions of sterility and skin preparation will be completed (i.e. alcohol wipes) Injections will be administered unilateral and/or bilaterally in accordance with the topography of the corresponding muscles (temporalis and masseter) into areas of maximal tenderness and pain. Plastic single use insulin syringes with 30 gauge needles will be used to inject 30 U intramuscularly into each masseter, divided evenly into 5 sites and 20 U will be injected into each temporalis, divided evenly over 5 sites. Injections will be completed by the principal investigator and supervisors who will be trained in botulinum toxin injections.
It is becoming increasingly apparent that commensal skin bacteria have an important role in wound healing and infection progression. However, the precise mechanisms underpinning many of these probiotic interactions remain to be fully uncovered. In this work, we demonstrate that the common skin commensal Cutibacterium acnes can limit the pathogenicity of the prevalent wound pathogen Pseudomonas aeruginosa in vivo. We show that this impact on pathogenicity is independent of any effect on growth, but occurs through a significant downregulation of the Type Three Secretion System (T3SS), the primary toxin secretion system utilised by P. aeruginosa in eukaryotic infection. We also show a downregulation in glucose acquisition systems, a known regulator of the T3SS, suggesting that glucose availability in a wound can influence infection progression. C. acnes is well known as a glucose fermenting organism, and we demonstrate that topically supplementing a wound with glucose reverses the probiotic effects of C. acnes. This suggests that introducing carbon source competition within the wound microenvironment may be an effective way to prevent or limit wound infection.
STUDY OBJECTIVE: We aimed to assess and compare the analgesic efficacy and adverse effects of intravenous subdissociative-dose ketamine to nebulized ketamine in emergency department (ED) patients with acute painful conditions.
METHODS: We conducted a prospective, randomized, double-blind, double-dummy clinical trial in adult patients (ages 18 and older) with a numerical rating scale pain score of ≥5. We randomized subjects to receive either a single dose of 0.3 mg/kg of intravenous (IV) ketamine or 0.75 mg/kg of nebulized ketamine through a breath-actuated nebulizer. Primary outcome was the difference in pain scores on the numerical rating scale between groups at 30 minutes postmedication administration. The secondary outcomes included the need for rescue analgesia, occurrences of adverse events in each group, and the difference in pain scores at 15, 30, 60, 90, and 120 minutes. We calculated a 95% confidence interval (CI) for a mean difference at 30 minutes, with a minimum clinically important difference set at 1.3 points.
RESULTS: We enrolled 150 subjects (75 per group). Mean pain scores through numerical rating scale were 8.2 for both groups at baseline, which decreased to 3.6 and 3.8 at 30 minutes, yielding a mean difference of 0.23 (95% CI -1.32 to 0.857). We observed no clinically concerning changes in vital signs. No serious adverse events occurred in any of the groups throughout the study period.
CONCLUSION: We found no difference between the administration of IV and nebulized ketamine for the short-term treatment of moderate to severe acute pain in the ED, with both treatments providing a clinically meaningful reduction in pain scores at 30 minutes.
This is a case of a spontaneous haemoperitoneum occurring in the second trimester of pregnancy which was managed with interventional radiology to avoid laparotomy and its potential consequences. We aim to raise awareness of this condition in pregnancy because the perinatal mortality rate is as high as 36%. Spontaneous haemoperitoneum in pregnancy (SHiP) has frequently been associated with vascular rupture from pre-existing endometriosis. Most cases of SHiP have been managed with laparotomy. However, transcatheter embolisation can impart lifesaving alternatives to more invasive interventions when caring for pregnant patients. More judicious use of imaging procedures may also help improve diagnostic and therapeutic pathways with SHiP. We recommend that high-risk pregnancies are managed in level IV regional perinatal healthcare centres, when possible, where subspecialists and alternative measures of management exist.
Colorectal surgery is a high-risk surgery that results in significant morbidity, and health care utilization in the form of readmission. Ileostomy creation is a significant risk factor in colorectal surgery rehospitalization. Effective continuous remote patient monitoring (CRPM) can reduce readmissions, but it has only been realized in select heart failure populations via invasive monitoring. The investigators will focus on colorectal CRPM in the elective, new ileostomy population through a structured cascading and escalating alert system. In this feasibility study, the investigators will use a wearable biosensor and collect ambulatory physiological data that are analyzed by machine learning algorithms, to generate personalized alerts of physiological perturbation in colorectal surgery patients in the post-discharge period. Alerts from this algorithm may be cascaded with other patient status data to inform management by the home health team via a structured protocol built into the electronic health record (EHR). The escalation pathway will engage home health nurses, colorectal care team nurses, ostomy nurses, and colorectal surgeons. The investigators will conduct surveys and semi-structured interviews with patients, and semi-structured interviews with providers, which will be used to evaluate the perceptions, acceptance, and experience of this CRPM solution.
Pityriasis rubra pilaris (PRP) is a rare dermatological condition which may present with ocular manifestations. We report a case of recurrent cicatricial ectropion (CE) with topical beta-blocker use in the rare dermatological condition PRP. The patient underwent release of scar tissue, lateral tarsal strip and full-thickness supraclavicular skin graft for CE following immunosuppression with methotrexate for 3 months. Postoperatively, CE recurred, with skin graft shrinkage and resumption of periocular disease activity, 8 weeks following the introduction of topical timolol. The patient was referred for further immunosuppression and substitution of timolol before consideration for further surgery. PRP has a variety of potential ocular complications. Surgery has a high risk of recurrence and should be performed when the overall disease is quiescent and drugs, which could trigger reactivation, have been discontinued and/or substituted. Skin grafts should be oversized to off-set shrinkage.
<P>PROBLEM TO BE SOLVED: To provide a composition having skin-whitening action and provide a cosmetic including the composition having skin-whitening action.  <P>SOLUTION: This skin-whitening composition includes, as essential components, soybean extract and Igusa rush extract, and one or plural kinds of extracts selected from seaweed extracts, shell extracts, herb extracts and mushroom extracts. Soybean extract and Igusa rush extract, and one or plural kinds of extracts selected from seaweed extracts, shell extracts, herb extracts and mushroom extracts are fermented with bacillus natto and the resultant fermentation solution is used as essential components to prepare skin-whitening composition. In an embodiment, Iiro (Ishige sinicola) extract is selected as a seaweed extract, freshwater clam extract is selected as a shellfish extract, oil-soluble liquorice extract is selected as a herb extract and the extract from underground stalk of Grifola froundosa to obtain the skin-whitening composition. The skin-whitening cosmetics includes these compositions.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
During pre-anesthesia consultation, all participants were assessed for airway conditions using usual clinical tests (Mallampati classification, Thyromental distance, mouth-opening test, upper lip biting test (ULBT), Head extension and Prayer sign). Demographic characteristics, diabetes duration, Blood glucose regulation and diabetes-related complications were also recorded.

On the day before surgery, patients were assessed for the palm print sign during preoperative evaluation rounds. On the day of surgery, after an intravenous line (IV) and complete monitoring, induction of anesthesia was initiated, and a muscle relaxant was used to facilitate intubation. Laryngoscopy was performed with a Macintosh metal laryngoscope blade by an anesthesiologist who had more than 2 years of intubation experience. McGrath® videolaryngoscope, McCoy laryngoscope, LMA Fastrack®, or i-gel® airway were kept ready for emergency situations. At this stage of the study, patients were categorized into two groups: difficult and easy laryngoscopy.
The present invention discloses a blood pressure reducing polypeptide, a separation method and the application thereof. The present invention relates to a polypeptide and the preparation thereof, which provides a blood pressure reducing polypeptide, a separation method and the application thereof to the preparation of blood pressure reducing medicines and foods. An amino acid sequence of the blood pressure reducing polypeptide is Ser-Leu-Leu-Pro-Pro-Tyr-Leu-Ser-Pro-Ala. The present invention has the separation method that collected zein powder is pulverized, and the undersized powder is used as enzymolysis substrate; alkali protease is added for hydrolysis to obtain hydrolyzate, ion exchange chromatography is carried out on the hydrolyzate to obtain active constituents of highly blood pressure reducing peptide, and then gel chromatography is carried out to obtain the active constituents of highly blood pressure reducing peptide; reversed-phase high-performance liquid chromatography is carried out for two times, and the constituents with high inhibitory activity, which are filtered out, are target products. The blood pressure reducing polypeptide with high blood pressure inhibiting activity originates from food protein, and thereby, the blood pressure reducing polypeptide has the advantages of no side effects, easy absorption and no effects on normal blood pressure. The present invention can be used for preparing blood pressure reducing medicines and foods.
A device is provided for use with a medical implant for delivering an agent to a designated site of action in a body of a patient. The agent-delivery device comprises a body member having an inner surface and a projection on the inner surface of the body member. An agent-delivery medium is associated with the body member. The agent-delivery medium includes a therapeutic agent for treating the body of the patient. The body member is adapted to be secured to the medical implant such that the projection operatively engages the medical implant for spacing the inner surface of the body member from the implant, and the agent-delivery medium is configured to release the therapeutic agent after implantation in the body of the patient. In alternative embodiments, the agent-delivery device comprises a first body member having an inner surface and a second body member having an inner surface. When connected, the inner surfaces of the first body member and the second body member define a cavity adapted to receive the medical implant. The body member may also define an opening therethrough, the opening configured to receive an anchor member for fixing the body member in a body of a patient.
Metabolic syndrome is strongly associated with obesity and the patients with this syndrome are at increased risk for cardiovascular disease. Obesity constitutes a strong risk factor for the development of chronic kidney disease. Among diabetics, obesity is known to amplify the risk for kidney disease. Bariatric surgery has yielded dramatic results including longitudinal loss of excess body weight and either complete reversal or significant improvement of several features of metabolic syndrome. In addition, many observational studies have demonstrated significant reduction in proteinuria after bariatric surgery.

However, the changes in the component of cardiovascular problem among metabolic syndrome and changes in renal filtration function or progression to end stage kidney disease in morbidly obese patients after weight loss surgery have not been extensively studied. Therefore, our study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
The present invention relates to external application traditional Chinese medicine for treating hyperosteogeny and a preparation method thereof. The external application traditional Chinese medicine is characterized in that the external application traditional Chinese medicine comprises liniment, fumigant, application agents and plaster for matching, wherein the liniment is a fresh earthworm solution. The fumigant is prepared from the raw materials of wolfberry bark, herba speranskiae tuberculatae, borneol and safflower. The application agents comprise raw wild aconite, clematis root, hemlock parsley, notoginseng, arisaema tubers and white mustard seeds. The plaster is prepared from the raw materials of curare, astragalus root, angelica, zedoary and oyster. The present invention can make medicine infiltrate the deep layers of affected parts according to a percutaneous absorption principle, by combining a carrier, and with a method of heat effect matching pharmacology. Besides, the present invention can infiltrate periphery tissues, soften spurs, prevent inflammation and relieve pain so as to treat temporary solutions, relax contracture, and restore force balance for treating permanent solutions. Thus, the present invention achieves the purpose of treating both the manifestation causes and the root causes of a disease, and has a certain curative effect.
ethod for the preparation of a medicinal product (ointment or cream) meant to prevent and cure, with no formation of scars, burns created by fire. Said medicinal preparation is characterized by the use of raw pharmaceutical materials such as olive oil (70-100 gm), wax (30-50 gm), incense (15-30 gm), and fraxinus ornus bark (120-30 gm). The mixture, after being boiled into a stainless metal container, is cooled off into a second container holding 1000 gm cool water. After cooling, it is placed anew into the first container to be heated until melting. This process is repeated 3 times. Finally, the water is drained off from the material, which takes the form of cream or ointment. The preparation and production of the above-mentioned preparation in multiple quantities permit its application and use on an industrial scale.
In the experimental group, the binaural sound, which was produced by the beat of 2Hz difference, is applied for 20 minutes from 20 minutes before arrival to the operating room. The sound generator is a smartphone device, set the volume corresponding to 60 dB, and hang it on the transport bed. Upon arrival in the operating room, before anesthesia, the volume is adjusted to 0.
The invention relates to a traditional Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases. The composition contains the following materials: keiskei, rhizoma acori graminei, rhizoma curcumae longae, curcuma aromatica, pseudo-ginseng, prepared nutgrass galingale rhizome, salvia miltiorrhiza, lignum dalbergiae odoriferae, rhizoma corydalis, leeches, ligusticum wallichii, root of kudzu vine, angelica, sargentgloryvine stem, fried trogopterus dung, giant knot weed, raw pollen typhae, safflower, prepared pinellia ternate, fructus schisandrae, common andrographis herb, astragalus membranaceus, Chinese honey locust and mint. When being adopted less, the traditional Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases disclosed by the invention functions as promoting circulation of qi and regulating blood, and has preventive and health caring functions on early stroke form and spirit feeling symptoms as sourness, swelling, stuffiness, pain, palpitation, terrifying and chest obstruction preventive disease engineering. When being frequently used, the composition can promote flow of qi and blood circulation, and is effective for medium stroke form and spirit feeling symptoms as numbness of limbs, weakness and fatigue. The composition has certain treatment and rehabilitation effects on stabbing pain of heart and brain, oppressive pain, angina, numbness pain, swelling pain and an eight-afraid symptom. The composition, being repeatedly used, functions as promoting circulation of qi and dissolving stasis, and has functions of removing depression and stasis on stroke form and spirit feeling symptoms as limb hemiplegia, stasis, infarct and blood exhaustion, brain injury, paraplegia, aphasia and imperception.
A lipoid soluble, normally water-insoluble and substantially fat-free vitamin, e.g. vitamin A, D, E and K is solubilized by means of a water-soluble hydroxy-polyoxyethylene ether, containing 10 to 150 oxyethylene groups to the molecule, of a long chain aliphatic alcohol containing 12 to 22 carbon atoms to the molecule.  The hydroxy-polyoxyethylene ethers have a melting point of 40 DEG  to 100 DEG  C., and preferably 40 DEG  to 65 DEG  C., and typical examples are hydroxy-10 (15, 23, 45, 105, 150)-oxyethylene lauryl ethers, hydroxy-20-oxyethylene cetyl ether and hydroxy-20-oxyethylene stearyl ether.  The vitamin may be dissolved in the molten ether, if desired, in the presence of an inert atmosphere and the solution so formed may then be diluted with water in all proportions.  Generally 2 to 20 parts, and preferably 5 to 12 parts, of the ether are used for each part of the vitamin and the final composition contains 2 to 10, and preferably 3 to 8 parts of the ether per 100 parts of the finished solution.  The vitamin compositions when dissolved in water may be mixed with water-soluble vitamins, e.g. thiamine, riboflavin, pyridoxine, ascorbic acid, and nicotinic acid or its amide. Viscosity increasing materials, sweetening agents, flavouring agents and colouring agents may be added.  The compositions may be incorporated in human and animal foods.ALSO:A vitamin composition for incorporating in animal foods comprises a lipoid-soluble normally water-insoluble and substantially fat free vitamin e.g. A, D, E and K, or a vitamin-containing material, dissolved in a water-soluble hydroxy - polyoxyethylene ether containing 10 to 150 oxyethylene groups to the molecule and being a long chain aliphatic alcohol containing 12 to 22 carbon atoms to the molecule.  The polyoxyethylene ethers have a melting point of 40 to 100 DEG C, and preferably 40 to 65 DEG C, and typical examples are hydroxy -10 (-15 23, 45, 105, 150)-oxyethylene lauryl ethers, hydroxy-20-oxyethylene-cetyl and -stearyl ethers and hydroxy-23-oxyethylene oleyl ether.  Generally 2 to 20 parts, and preferably 5 to 12 parts, of the ether are used for each part of vitamin.  The vitamin may be dissolved in the molten ether, if desired in the presence of an inert atmosphere.  An example is given in which the solid produced from vitamin A and hydroxy-23-oxyethylene lauryl ether is incorporated in an animal food containing 90 per cent of a mixture of oil-expressed soyabean meal, alfalfa meal and oatmeal and 10 per cent of a mixture of calcium phosphate, potassium phosphate, sodium chloride and essential trace elements.