anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE OF REVIEW: We evaluate available evidence for the role of inflammation in depression. We reappraise literature involving systemic inflammation, neuroinflammation and neurotransmission and their association with depression. We review the connection between depression, autoimmunity and infectious diseases. We revise anti-inflammatory treatments used in depression.
RECENT FINDINGS: Peripheral inflammatory markers are present in a subset of patients with depression and can alter common neurotransmitters in this population but there is no clear causality between depression and systemic inflammation. Infectious conditions and autoimmune illnesses do not have a clear correlation with depression. Certain medications have positive evidence as adjunctive treatments in depression but studies are heterogenic, hence they are sparsely used in clinical settings. The current evidence does not fully support inflammation, infections or autoimmunity as possible etiologies of depression. The available studies have numerous confounders that obscure the findings. Anti-inflammatory agents may have potential for treatment of depression, but further research is needed to clarify their usefulness in routine clinical practice.
PURPOSE:To obtain the titled preparation, by compounding a drug containing etintidine or its acid addition salt and soluble in the stomach with a drug soluble in the intestines at a specific ratio. CONSTITUTION:A long-acting preparation containing etintidine or its acid addition salt is obtained by compounding a drug containing the compound of formula (etintidine) or its acid addition salt and soluble in the stomach with a drug containing etintidine and soluble in the intestines at a ratio of 0:100-50:50, preferably 10:90-30:70 in terms of the amount of etintidine existing in each drug. The drug soluble in the intestines is pills or granules prepared by coating the above drug soluble in stomach with an enteric material (e.g. eudragit L, hydroxypropylmethyl cellulose phthalate, etc.). It can be administered in the form of pill, granule, capsule, or a sandwiched tablet consisting of an enteric tablet sandwiched with a pair of tablets soluble in the stomach. The etintidine has pharmacological activity to suppress the secretion of gastric acid secreted by the stimulation with histamine, etc.
Etodolac tablets are contraindicated in patients with known hypersensitivity to etodolac or other ingredients in etodolac tablets.

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    In the setting of coronary artery bypass graft (CABG) surgery (see Error! Hyperlink reference not valid.).
The investigators will examine the efficacy of an eHealth intervention, namely Healthy Parental Online Education (HOPE), to increase fruit and vegetable intake and active playtime among toddlers enrolled in Early Head Start programs in Lubbock. This study will be an 8-week randomized control trial (RCT). Participants will be randomly assigned to the intervention or control group via block randomization with randomly selected block sizes of 4. Randomization will be conducted by a researcher not involved in data management. The statistical software R version 3.5.1 will be used to determine to generate randomized arm allocation sequences through a fixed seed. The randomization will be stratified by centers. Those allocation sequences will be printed out and individually stored in serially numbered, opaque, sealed envelopes. Participants will be informed of group allocation via opaque and sealed envelopes after the collection of baseline data.

Participants in the intervention group will receive 8 sessions of online multi-component HOPE nutrition intervention. While the control group will receive no intervention, the investigators will provide the control group with a copy of the booklet. This booklet will include basic nutrition recommendations for a healthy diet for adults and children, consistent with 2020 U.S. Department of Agriculture dietary guidelines.

Pre- and post-assessment will be conducted to see changes in variables of interest from baseline (T1), post-intervention (T2), to 3 months (T3). Sociodemographic and anthropometrics of parents and toddlers will be measured at T1. The investigators will also measure carotenoids in the skin of both parents and children using the Veggie Meter (Longevity Link, Salt Lake City, UT) to assess fruit and vegetable intake. Parental nutritional knowledge, attitudes related to healthy eating and activity, feeding practices, and self-efficacy will be assessed using a self-administered questionnaire. The research team will also ask parents to recall the physical activity and sedentary times of toddlers using a self-report survey. Parents will take electronic food photos using their mobile devices for three days to capture the food and beverage intake of toddlers at home. The same measurements and survey will be used at T2 except for variables related to anthropometrics and sociodemographics. Finally, the investigators will only measure the food intake of toddlers, physically active and sedentary times of toddlers, and carotenoid levels of parents and toddlers at T3, using the same methods and procedures mentioned above.
The ethanolamine salt of 6-cyclohexyl 1-hydroxy 4-methyl 2(1H)-pyridone is made by (a) reacting 2-cyclohexyl 4-methyl 6-chloro pyridine with anhydrous NH3 under high pressure to obtain the 6-amino cpd. The prod. is treated with peracetic acid in acetic acid to oxidise the pyridine nitrogen and the (c) neturalised with aq. NaHCO3 and extra.. The soln. is then concentrated to dryness and diazotised with NaNO2 at low temp. in aq. soln. which is then poured onto a mixt. of H2SO4 and hot water to obtain 6-cyclohexyl 1-hydroxy 4-methyl 2(1H)-pyridone which precipitates at neutral pH. This is dissolved in ether for dehydration with anhydrous Na2SO4 and a salt is formed with ethanolamine and the solvent is evapd..
BACKGROUND: In Canada, adults with chronic noncancer pain face a persistent insufficiency of publicly funded resources, with the gold standard multidisciplinary pain treatment facilities unable to meet the high clinical demand. Web-based self-management programs cost-effectively increase access to pain management and can improve several aspects of physical and emotional functioning. Aiming to meet the demand for accessible, fully automated resources for individuals with chronic noncancer pain, we developed a French web- and evidence-based self-management program, Agir pour moi (APM). This program includes pain education and strategies to reduce stress, practice mindfulness, apply pacing, engage in physical activity, identify and manage thinking traps, sleep better, adapt diet, and sustain behavior change.
OBJECTIVE: This study aims to assess the APM self-management program's feasibility, acceptability, and preliminary effects in adults awaiting specialized services from a center of expertise in chronic pain management.
METHODS: We conducted a mixed methods study with an explanatory sequential design, including a web-based 1-arm trial and qualitative semistructured interviews. We present the results from both phases through integrative tables called joint displays.
RESULTS: Response rates were 70% (44/63) at postintervention and 56% (35/63) at 3-month follow-up among the 63 consenting participants who provided self-assessed information at baseline. In total, 46% (29/63) of the participants completed the program. We interviewed 24% (15/63) of the participants. The interview's first theme revolved around the overall acceptance, user-friendliness, and engaging nature of the program. The second theme emphasized the differentiation between microlevel and macrolevel engagements. The third theme delved into the diverse effects observed, potentially influenced by the macrolevel engagements. Participants highlighted the features that impacted their self-efficacy and the adoption of self-management strategies. We observed indications of improvement in self-efficacy, pain intensity, pain interference, depression, and catastrophizing. Interviewees described these and various other effects as potentially influenced by macrolevel engagement through behavioral change.
CONCLUSIONS: These findings provided preliminary evidence that the APM self-management program and research methods are feasible. However, some participants expressed the need for at least phone reminders and minimal support from a professional available to answer questions over the first few weeks of the program to engage. Recruitment strategies of a future randomized controlled trial should focus on attracting a broader representation of individuals with chronic pain in terms of gender and ethnicity.
TRIAL REGISTRATION: ClinicalTrials.gov NCT05319652; https://clinicaltrials.gov/study/NCT05319652.
Chemical analytical device, esp. for immunoassay, involving contact of the sample with a reagent(s) to form a detectable substance (I) for qualitative or quantitative determn. is new when it comprises a continuous sheet of at least 2 segments. The first one contains a site on which a reagent(s) is present from the start, and on which contact between it an the sample can take place. The second one contains a site, esp. with (I) present from the start and on which its presence can be shown. These first and second segments are foldable in such a way that the site with the reagents can be brough to overlap the detection site. It comprises an arrangement(s) for sepn.of reagent(s) that has not reacted during the contact between sample and reagent(s). The arrangement is placed so that it is activated before the presence of (I) is shown. The segments present can be folded in such a way that desired segments overlap each other for performance of the analytical step.
The investigators approach will combine HUT testing coupled with autonomic testing that includes continuous blood pressure and HR measurements, Baroreflex Sensitivity and Hear Rate Variability, to establish objective autonomic profiles, along with vascular testing including Pulse Wave Velocity, Ankle Brachial Index at rest and measures of blood volume of different compartments, Systemic Vascular Resistance and cardiac output at rest and in response to hand-grip stress. This will allow the treating physician to provide patients with a specific diagnosis, and ultimately develop data for more focused, rational treatments than currently achieved. The full vascular profile is also novel and has the potential to improve therapeutic management of the participants independent of the outcomes with the vitamin D supplementation. This study is designed to recruit 80 participants into 4 groups of 20 each. The 4 groups represent non OI (those recruited from the clinics for nausea but without a positive tilt test) or those showing orthostatic intolerance (POTS alone, OH, and syncope). The general objective of this proposal is to address this gap in knowledge by determining vascular function, the neurohumoral profile and autonomic status supine and in response to HUT in OI subjects with low vitamin D levels in comparison with subjects who test negative for OI on the HUT.

The investigators aim to examine the effect of vitamin D replacement on these measures, providing the possibility of therapeutic use of vitamin D to treat or ameliorate the symptoms associated with OI.
The present invention relates to a compound preparation for treating child diarrhea, which is prepared by traditional Chinese medicines and western medicines (by weight part). The traditional Chinese medicines comprise 8 to 11 of ginseng, 8 to 11 of Chinese dittany bark, 8 to 10 of parched white atractylodes rhizome, 8 to 10 of dried old orange peel, 8 to 10 of prepared licorice root, 8 to 11 of yam, 4 to 6 of hyacinth beans, 4 to 6 of lotus seeds, 4 to 6 of amomun fruit, 2 to 4 of parched coix seeds and 4 to 6 of herba agastachis. The western medicines comprise 0.05-0.1 of lomotil, 0.05-0.1 of furazolidone, 0.0125-0.025 of hydrochlorothiazide, 0.6-1.0 of dried yeast, 0.3-0.5 of vitamin C and 0.8 to 1.0 of terramycin. The preparation method comprises that Chinese dittany bark, dried old orange peel, parched white atractylodes rhizome, prepared licorice root, yam and herba agastachis are soaked by warm water according to the required amount and are decocted for 2 times by a conventional decocting method, and medicine juice is converged and concentrated. The traditional Chinese medicines of other components are pulverized and sieved, and the western medicines are porphyrized to powder, and the traditional Chinese medicines and the western medicines are commonly mixed in concentrated medicine juice. The medicine is obtained after the traditional Chinese medicines and the western medicines are dried, porphyrized to powder and sieved. The preparation can fast control the pathogenetic condition of infant diarrhea, and the curative effects are significant.
Spinal cord injury (SCI) is devastating for patients, and currently lacks effective treatments. Dysbiosis commonly occurs after SCI and has significant immunomodulatory effects, but its impact on recovery remains unclear. The current study investigated the effects and mechanisms of fecal microbiota transplantation (FMT) in SCI. FMT was administered in a rat model of SCI and spinal pathology, inflammatory cytokines, and gut microbiome composition were assessed. Flow cytometry identified a source of interleukin (IL)-17 in spinal cord tissues, and carboxyfluorescein succimidyl ester labeling tracked γδ T cell migration. In vitro coculture was used to analyze the regulatory mechanisms of γδ T cells. Seahorse analysis was used to profile dendritic cell (DC) metabolism. Here we show that FMT improved spinal pathology and dampened post-injury inflammation. It also corrected post-SCI dysbiosis, increasing levels of the beneficial bacterium Akkermansia. The therapeutic effects of FMT were mediated by IL-17 produced by γδ T cells. FMT regulated γδ T cells via DC-T regulatory cell interaction, and induced metabolic reprogramming in DCs. These findings suggest that FMT represents a promising therapeutic approach for SCI, with potential to target IL-17+ γδ T cells. Elucidating the interconnected pathways between microbiota, immunity, and the spinal cord may facilitate novel treatment strategies.
Dapansutrile starting at 500 mg PO BID plus Pembrolizumab 200 mg IV every three weeks. Dose escalation is planned to a maximum of 1000 mg BID of dapansutrile + pembrolizumab.
To determine the HFE genotype of female Asian study volunteers, we collected venous blood samples and extracted DNA from these blood samples. HFE genotype was determined as CC, CT, and TT and used to assess possible differences in iron status as a function of genotype. To measure the impact of genotype on non-heme Fe absorption, a sub-group of women with the CC (n=10) or TT (n=11) genotype were invited to return for an Fe absorption study. Each volunteer consumed stable 57Fe (as ferrous sulfate). Two weeks after ingesting this tracer, a blood sample was collected from each woman and the amount of non-heme (57Fe) iron incorporated into red blood cells was measured with magnetic sector thermal ionization mass spectrometry. Possible associations between iron status and iron absorption as a function of genotypes were explored. Data from this study will provide information that aims to improve human health by better understanding the iron requirements of individuals with different genetic background.
A method is for extracting shrimp oil. Particularly, shrimp processing water (EPC) is recovered and subjected to a dissolved air flotation (DAF) system after adding a flocculating agent. The suspended and dissolved solids form aggregates that are recovered from the surface by a procedure referred to as “skimming”. The skimming product is then directed into a horizontal centrifuge (decanter) in order to separate the solid phase (SOC) and the liquid phase having water and shrimp oil. The liquid phase is pumped into the 3-phase vertical centrifuge in order to separate the shrimp oil, the water, and the solids. The solids recovered after using the separator can then be added to the solid phase obtained after settling. The resulting shrimp oil is very rich in astaxanthin and the resulting water contains very little organic material and can be returned to the general processing plant effluent.
PURPOSE:To obtain inexpensive material generally usable for removing endotoxin by using a porous body in a specified porous state, consisting of methyl methacrylate polymer contg. methyl methacrylate above a specified proportion, based on monomer fraction to selectively remove endotoxin. CONSTITUTION:A hollow fiber is obtd. for example, by extruding a spinning soln. dissolved methyl methacrylate polymer and methyl methacrylate in a solvent from the outer discharge aperture of an annular spinneret by introducing dry nitrogen gas to the inside thereof to make hollow-fibrous material, and by coagulating and removing the solvent in water. A module is made of the material for removing endotoxin, consisting of the porous body contg. >=50% methyl methacrylate, based on the monomer fraction and having 30-90% equilibrium moisture content in a hydrated state at 20 deg.C. The liq. to be treated is circulated outside of the hollow fiber module. The endotoxin in the liq. to be treated in removed by adsorbing with the hollow-fibrous material for removing endotoxin.
Patients receive erlotinib hydrochloride orally or via gastrostomy tube once daily in weeks 1-9 and then for 2 years following completion of radiation therapy. Beginning on day 1 of week 2, patients undergo radiation therapy once daily, 5 times a week, for 5-7 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.
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     DOXIL liposomal infusion can cause myocardial damage, including acute left ventricular failure. The risk of cardiomyopathy was 11% when the cumulative anthracycline dose was between 450 mg/m2 to 550 mg/m2. Assess left ventricular cardiac function prior to initiation of DOXIL liposomal infusion and during and after treatment [see Warnings and Precautions (5.1)].
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     Serious, life-threatening, and fatal infusion-related reactions can occur with DOXIL liposomal infusion Acute infusion-related reactions occurred in 11% of patients with solid tumors. Withhold DOXIL liposomal infusion for infusion-related reactions and resume at a reduced rate. Discontinue DOXIL liposomal infusion for serious or life-threatening infusion-related reactions [see Warnings and Precautions (5.2)].
Described herein is a drug product delivery device and method of delivering a drug on a swab. The drug product delivery device may include an applicator platform housed within a rigid housing. The applicator platform may be in the form of a plunger. The foil drug reservoir cap creates a fluid storage chamber disposed between the foil drug reservoir cap and the plunger. A series of fluidic channels carry fluid from the fluid storage chamber to an applicator. A frangible seal is attached to the plunger between the fluid storage chamber and the applicator. The frangible seal blocks a fluid from moving from the fluid storage chamber into the series of fluidic channels. Actuation of the plunger causes the frangible seal to be ruptured, which causes the fluid to exit the fluid storage chamber and enter into the fluidic channels. The fluidic channels carry the fluid to the applicator.
PURPOSE: To assess changes in neurovascular coupling (NVC) by evaluating the relationship between cerebral perfusion and brain connectivity in patients with end-stage renal disease (ESRD) undergoing hemodialysis versus in healthy control participants. And by exploring brain regions with abnormal NVC associated with cognitive deficits in patients, we aim to provide new insights into potential preventive and therapeutic interventions.
MATERIALS AND METHODS: A total of 45 patients and 40 matched healthy controls were prospectively enrolled in our study. Montreal Cognitive Assessment (MoCA) was used to assess cognitive function. Arterial spin labeling (ASL) was used to calculate cerebral blood flow (CBF), and graph theory-based analysis of results from resting-state functional magnetic resonance imaging (rs-fMRI) was used to calculate brain network topological parameters (node betweenness centrality [BC], node efficiency [Ne], and node degree centrality [DC]). Three NVC biomarkers (CBF-BC, CBF-Ne, and CBF-DC coefficients) at the whole brain level and 3 NVC biomarkers (CBF/BC, CBF/Ne, and CBF/DC ratios) at the local brain region level were used to assess NVC. Mann-Whitney U tests were used to compare the intergroup differences in NVC parameters. Spearman's correlation analysis was used to evaluate the relationship among NVC dysfunctional pattern, cognitive impairment, and clinical characteristics multiple comparisons were corrected using a voxel-wise false-discovery rate (FDR) method (p < .05).
RESULTS: Patients showed significantly reduced global coupling coefficients for CBF-Ne (p = .023) and CBF-BC (p = .035) compared to healthy controls. Coupling ratios at the local brain region level were significantly higher in patients in 33 brain regions (all p values < .05). Coupling ratio changes alone or accompanied by changes in CBF, node properties, or both CBF and node properties were identified. In patients, negative correlations were seen between coupling ratios and MoCA scores in many brain regions, including the left dorsolateral superior frontal gyrus, the bilateral median cingulate and paracingulate gyri, and the right superior parietal gyrus. The correlations remained even after adjusting for hemoglobin and hematocrit levels.
CONCLUSION: Disrupted NVC may be one mechanism underlying cognitive impairment in dialysis patients.
The invention discloses a traditional Chinese medicine for treating hematuria caused by spleen failing to control blood. The traditional Chinese medicine for treating the hematuria caused by the spleen failing to control blood is characterized by being prepared from, by weight, 15 parts of radix rehmanniae praeparata, 30 parts of a marginate rockbell herb, 30 parts of twigs and leaves of Tibet lyonia, 15 parts of Asiatic cornelian cherry fruits, 27 parts of manyprickle acanthopanax roots, 9 parts of schisandra rubriflora (Franch.) Rehd. et Wils, 30 parts of Japan euonymus, 15 parts of hypoestes triflora, 30 parts of rhizomes of Watt Tupistra, 15 parts of bunge auriculate roots, 10 parts of Stebbinsia umbrella (Franch.) Lipsch, 30 parts of smoothfruit ventilago roots and stems, 15 parts of longflower stringbush roots, 15 parts of semen lablab album, 30 parts of limonium bicolor (Bag.) Kuntze, 30 parts of an aizoon stonecrop herb and 6 parts of licorice. The medicines in the formula can coordinate with each other, have the synergistic effect and jointly have the effects of tonifying the spleen and kidney, tonifying qi and controlling blood, the traditional Chinese medicine can be effectively treat the hematuria caused by the spleen failing to control blood. Over the years, the use results of multiple cases of patients show that the effective rate is up to 98%.