anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
We have been conducting a study of self-collected cervicovaginal specimens and carcinogenic human papillomavirus (HPV) DNA testing for cervical cancer screening of women living in the Mississippi Delta, who have disproportionately high rates of cervical cancer. To date, we have noted high levels of participation as well as high percentages of completion and return of the home self-collection. Although we have recruited some under-screened women into our study, it was clinic-based (i.e., under-screened women were still required to come to the health department clinic), using Mississippi State Department of Health district clinics. In reality, women who get cervical cancer in the Mississippi Delta are unlikely to come to clinics except perhaps for giving birth, years before they are diagnosed with cancer. Thus, as an ancillary study to our work in Mississippi, we are proposing an outreach study to determine whether under-screened women, if approached via door-to-door recruitment, would participate (get screened) by one of two community outreach-based cervical cancer screening modalities, home-based self-collection and HPV testing or clinic-based cytology screening, and which of the two modalities they prefer. We will recruit door-to-door 400 under-screened, eligible women aged 26-65 years living in the Mississippi Delta. Consenting, eligible women will be given a choice of taking and using a self-collection kit on their own or coming to the local Health Department clinic for cervical cytology screening. Under the assumption that only 5% of this under-screened population would choose to undergo screening without intervention, recruitment of 400 women into the study will permit us to detect a 2-fold increase in participation in screening (defined as completing screening) with 90% power (alpha = 0.05). In this scenario, we will be able to detect with 90% power (alpha = 0.05) a 25% preference for one of the screening methods (75% vs. 50% (no preference)).
AIM: In the pediatric surgical population, Emergence Delirium (ED) poses a significant challenge. This study aims to develop and validate machine learning (ML) models to identify key features associated with ED and predict its occurrence in children undergoing tonsillectomy or adenotonsillectomy.
METHODS: The analysis involved data cleaning, exploratory data analysis (EDA), supervised predictive modeling, and unsupervised learning on a medical dataset (n = 423). After preliminary data cleaning, EDA encompassed plotting histograms, boxplots, pairplots, and correlation heatmaps to understand variable distributions and relationships. Four predictive models were trained including logistic regression (LR), random forest (RF), Support Vector Machine (SVM), and Gradient Boosting (XGBoost). The models were evaluated and compared using Receiver Operating Characteristic (ROC) Area Under the Curve (AUC), precision, recall, and feature importance. The RF model showed better performance and was used for the test (AUC-ROC 0.96, precision 1.00, and recall 0.92 on the validation set). K-means clustering was applied to find groups within the data. Elbow method and silhouette scores were used to determine the optimal number of clusters. The formed clusters were analyzed by aggregating features to understand the characteristics of each cluster.
RESULTS: EDA revealed significant positive correlations between age, weight, American Society of Anesthesiologists (ASA) health score, and surgery duration with the risk of developing ED. Among the ML models, RF achieved the highest performance. Key predictive variables, based on the model's feature importance, included delirium screening scales, extubation time, and time to regain consciousness. Unsupervised K-means clustering identified 2-3 optimal clusters, which represented distinct patient subgroups: younger, healthier, low-risk individuals (cluster 0), and older patients with increasing chronic disease burden, higher delirium screening scores, and consequently higher post-operative delirium risk (clusters 1 and 2).
CONCLUSIONS: ML techniques are valuable tools for extracting insights and making accurate predictions from healthcare data. High-performing algorithm-based models can be implemented for clinical decision support systems, facilitating early identification and intervention for ED in pediatric patients. By investigating various variables, it is possible to assess risk and implement preventive measures effectively. Furthermore, unsupervised clustering reveals distinct patient subgroups, enabling personalized perioperative management strategies and enhancing overall patient care.
Soldiers of the Mexican Army with obesity were subjected to an intense 60-day weight-loss course consisting of a controlled diet, daily physical training, and psychological sessions. The nutritional treatment followed the European Society of Cardiology (ESC) recommendations, incorporating elements of the traditional milpa diet in the nutritional intervention. The total energy intake was reduced by 200 kcal every 20 days, starting with 1,800 kcal and ending with 1,400 kcal daily. On average, the participants reduced their body weight by 18 kg. We employed an innovative approach to monitor the progress of the twelve soldiers who completed the entire program. We compared the untargeted metabolomics profiles of their urine samples, taken before and after the course. The data obtained through liquid chromatography and high-resolution mass spectrometry (LC-MS) provided insightful results. Classification models perfectly separated the profiles pre and post-course, indicating a significant reprogramming of the participants' metabolism. The changes were observed in the C1-, vitamin, amino acid, and energy metabolism pathways, primarily affecting the liver, biliary system, and mitochondria. This study not only demonstrates the potential of rapid weight loss and metabolic pathway modification but also introduces a non-invasive method for monitoring the metabolic state of individuals through urine mass spectrometry data.
This trial will be a randomized unmasked open-label study of Transnasal humidified high-flow oxygen/air delivery compared to conventional tubeless anesthesia during airway surgery in pediatric patients. This will be a single center study at MEE main campus on 243 Charles St, Boston, MA for the use of the high-flow oxygen delivery device.

Two study arms will be used in this study. Subjects will be treated with both study arms over the course of two study visits. Enrolled patients will be patients that present themselves routinely for removal of laryngeal papilloma. These patients, once enrolled, will be randomized to either receive conventional tubeless anesthesia or standard anesthesia with the addition of transnasal high-flow oxygen/air for their next scheduled anesthetic. Oxygen flows for the high-flow nasal cannula will be titrated down to achieve a FiO2 value of 21% during lasering. The anesthesia method not chosen will be used for the following anesthetic for each patient. Intraoperatively patients will be monitored for number of desaturations below 90 percent, length of these desaturations and severity, number and type of interventions necessary by the anesthesiologist, and number of intubations necessary by the anesthesiologist. Flow rates appropriate for the age of the patient will be used and also be recorded within these cases. Adverse events and complications will also be recorded for both anesthetics.
Subjects will be randomized to receive 10 sessions of sham rTMS and active Neurofunctional Electrical Acupuncture. Stimulation will be given on consecutive days (Monday- Friday) for 2 weeks: rTMS placebo coil over the primary motor cortex area and neurofunctional electrical acupuncture at 1Hz, continuous, 10mA current for 20 minutes over peripheral region.
OBJECTIVE: Myocardial infarction (MI) -induced cardiac dysfunction can be attenuated by aerobic exercises. This study explored the mechanism of interval training (IT) regulating cardiac function in MI rats, providing some theoretical basis for clarifying MI pathogenesis and new ideas for clinically treating MI.
METHODS: Rats were subjected to MI modeling, IT intervention, and treatments of the Transforming growth factor-β1 (TGF-β1) pathway or the nod-like receptor protein 3 (NLRP3) activators. Cardiac function and hemodynamic indicator alterations were observed. Myocardial pathological damage and fibrosis, reactive oxygen species (ROS) level, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, MDA content, inflammasome-associated protein levels, and inflammatory factor levels were assessed. The binding between TGF-β1 and receptor was detected.
RESULTS: MI rats exhibited decreased left ventricle ejection fraction (LVEF), left ventricle fractional shortening  (LVFS), left ventricular systolic pressure  (LVSP), positive and negative derivates max/min (dP/dt max/min) and increased left ventricular end-systolic pressure (LVEDP), a large number of scar areas in myocardium, disordered cell arrangement and extensive fibrotic lesions, increased TGF-β1 and receptor binding, elevated ROS level and MDA content and weakened SOD, CAT and GSH-Px activities, and up-regulated NLRP3, apoptosis-associated speck-like protein containing a CARD  (ASC) and cleaved-caspase-1 levels, while IT intervention caused ameliorated cardiac function. IT inactivated the TGF-β1 pathway to decrease oxidative stress in myocardial tissues of MI rats and inhibit NLRP3 inflammasome activation. Activating NLRP3 partially reversed IT-mediated improvement on cardiac function in MI rats.
CONCLUSION: IT diminished oxidative stress in myocardial tissues and suppressed NLRP3 inflammasome activation via inactivating the TGF-β1 pathway, thus improving the cardiac function of MI rats.
Lenalidomide API will administered at a starting dose of 2 mg/kg/day. Lenalidomide will be provided as either a capsule (2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg or 25 mg) or as an oral suspension (10mg/mL).
Multiple image capture devices are located in an operating room to capture video of the entirety of the operating room. A surgical tracking server applies one or more models to the captured video to determine states of objects in the operating room from which a phase of the operating room is determined. A surgical time-out where information about a surgical procedure is audibly provided by people in the operating room during the surgical procedure. From audio and video of the operating room, the surgical tracking server determines whether the time-out was performed and identifies audio and video corresponding to the surgical time-out. The identified audio and video are compared to criteria to evaluate completeness of the surgical time-out. A quality metric for the time out based on the captured video data based on characteristics of the video or audio of the operating room may also be generated.
In the preoperative period, the researcher will conduct a survey on the morning of the surgery day, approximately 1 hour before the surgery, using the "Child and Family Introductory Data Form", which includes the sociodemographic characteristics of the child and the accompanying parent. The child himself/herself will be asked to score the level of surgery-related anxiety using the "CAS" score, and the child, the parent, and the researcher will be asked to score the child's fear level regarding the surgery using the "CFS" score. Data collection will take approximately 10 minutes in total. Immediately afterwards, the child will be asked by the researcher to read the story book "One Child, One Miracle". This group will be asked to just read the book without turning on the book's augmented reality feature. Afterwards, using the same scales, children will score the "CAS" scales, and the child, parent and researcher will score the "CFS" scales.
PURPOSE: The Iliotibial band (ITB) is a fibrous thickening of the fascia lata originating at the iliac crest and inserting at Gerdy's tubercle on the lateral tibia. The ITB significantly contributes to lateral knee stabilisation. Due to its size, tensile strength and easy access, it is widely used in orthopaedic surgery as an autograft during reconstruction procedures. Although ITB harvesting may result in complications, such as reduced knee extension or hip flexion, no safety margins or guidelines have been proposed for the procedure. Our aim was to determine the maximal safe length of an ITB graft, that is, that does not harm the lateral collateral ligament (LCL), tensor fasciae latae (TFL), gluteus maximus (GM) or adjacent structures, and reduce the complication rate.
METHODS: The study included 50 lower limbs of 25 human cadavers, previously fixed in 10% formalin solution. The inclusion criterion was the lack of visible signs of surgical interventions in the study region. Forty lower limbs were included in the study: 16 female (mean age 83.1 ± 3.4 years) and 24 male (mean age 84.2 ± 6.8 years). Dissection was performed with a previously established protocol. Morphometric measurements were then obtained twice by two researchers.
RESULTS: The mean femur length was 404.8 mm [female (F) = 397.3 mm, male (M) = 409.9 mm, standard deviation (SD): F = 23.8 mm, M = 24.1 mm]. The mean ITB length was 318.9 mm (F = 309.4 mm, M = 325.2 mm, SD: F = 25.7 mm, M = 33.7 mm). Longer femurs were associated with longer ITB (p < 0.05). The mean distance from the insertion of the GM to the myofascial junction of TFL and ITB was 34.6 mm (F = 34.5 mm, M = 34.6 mm, SD: F = 3.2 mm, M = 3.3 mm). The longer femurs or ITBs demonstrated a greater distance from GM insertion to the myofascial junction of the TFL and ITB (p < 0.05).
CONCLUSION: ITB grafts longer than 21 cm may contribute to the greater risk of TFL rupture. Based on simple measurements of the femur length, the surgeon may assess approximate ITB length, and thus assess the length of the maximal graft length. Moreover, to avoid harming the LCL, the incision should be performed 5 cm proximal to the articular surface of the lateral femoral condyle or 13 mm proximal to the lateral femoral epicondyle. Such preparation and preoperative planning may greatly reduce the risk of complications during ITB harvesting, while performing, for instance, the over-the-top technique for anterior cruciate ligament reconstruction in skeletally immature patients.
LEVEL OF THE STUDY: Basic I.
BACKGROUND Shoulder subluxation in patients with stroke impairs recovery and quality of life. Kinesiology tape is elastic and water-resistant, is commonly used to prevent musculoskeletal injury, and is increasing in use for rehabilitation of patients requiring neurological or physical rehabilitation. This study included 35 patients with shoulder subluxation following stroke and aimed to compare outcomes from standard physical therapy with and without shoulder kinesiology taping. MATERIAL AND METHODS This randomized controlled study involved 35 participants. The patients were randomized into a shoulder kinesiology taping group (n=18) or sham taping group (n=17). All patients underwent a conventional rehabilitation exercise program 5 days a week for 6 weeks. Half of the patients underwent shoulder kinesiology taping, and the other half underwent sham taping. Pre- and post-assessment scores were recorded for all participants for shoulder subluxation distance (SSD), active range of motion (AROM), visual analog scale (VAS), shoulder pain and disability index (SPADI), and modified Barthel index (MBI). RESULTS After the intervention, SSD, AROM, VAS, SPADI, and MBI improved significantly in the shoulder kinesiology taping and sham taping groups (P<0.05). Also, the shoulder kinesiology taping group showed more effective changes in SSD, AROM, VAS, SPADI, and MBI than the sham taping group (P<0.05). CONCLUSIONS These results suggest that the shoulder kinesiology taping is effective in improving SSD, AROM, VAS, SPADI, and MBI in patients with hemiplegic shoulder subluxation.
1426042 Immunological agent AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE 26 Feb 1973 [26 Nov 1971] 54993/71 Heading A5B A water-soluble immunological agent is prepared by cultivating a strain of Mycobacteria or Nocardia, isolating the cultivated cells, disrupting the cells, isolating the ruptured cell wall material, removing lipids, protein and nucleic acids from the cell wall material, digesting the remaining material in a microlytic enzyme, removing any undigested solid residue and collecting the. aqueous fraction of the remainder. The product is characterized by containing 12-15% of amino, sugars, consisting of equimolar amounts of D-glucosamine and D-muramic acid; containing 12-15% of aminoacids consisting of L-alanine, D- alanine, D-glutamic acid and meso-alpha, betadiaminopimetic acid in the ratio 1:3:1:1; containing 60-70% of neutral sugars consisting of D-arabinose and D-galactose in the ratio 2:1; containing less than 5% of lipids, having an optical rotation [alpha]D in water of 11.3‹ Œ 0.5‹, having terminal ultraviolet absorption below 230 nm., having infra-red absorption at 1650, 1520 and 1000-1100 cm<-1>; and on lyophilization becoming white and fluffy, soluble in water to provide an opalescent solution, insoluble in ether, chloroform, acetone and mixtures of ethanol and chloroform. Bacteria strains specified include: Mycabacterium tuberculosis, variant hominis or bovis, Mycobacterium kansasii, Mycobacterium smegmatis, Calmette Guerin bacilli. In a preferred process, the cultivated cells may be suspended in water and disrupted in a French press or by ultrasonic vibrations. The ruptured cell wall material may be isolated by first centrifuging the disrupted cells first at low speed to precipitate any whole cells and then again at higher speed to precipitate the ruptured cell wall material. Lipids may be extracted with alcohol, acetone or chloroform, protein may be removed with trypsin or chymotrypsin and nucleic acids may be removed with desoxyribomnuclease. The murolytic enzyme may be lysozyme in the presence of a buffer agent. The final product may be repeatedly lyophilized and redissolved in water to remove the buffer. The final solution is filtered through a polydextran gel column.
<P>PROBLEM TO BE SOLVED: To provide a composite powder which provides a good feeling in use and improves irritative feeling or roughness caused in its application by a nacreous pigment and a cosmetic containing the powder.  <P>SOLUTION: The composite powder comprises a nacreous pigment with its surface covered with barium sulfate. The powder is prepared by suspending the nacreous pigment in water and adding, to the resultant suspension, (1) an aqueous solution containing barium ions and (2) an aqueous solution containing sulfate ions, simultaneously or one after another, under agitation to precipitate barium sulfate on the surface of the nacreous pigment. Thus obtained composite powder is compounded into a cosmetic. Preferably, the nacreous pigment is mica coated with titanium oxide.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
Participants in the usual care group will also receive the printed information and links to the AHA's Life's Simple 7 program without explicit skills and training, including education and stress management. We will encourage stress management by watching and practicing yoga programs by providing a yoga mat.
PURPOSE:To obtain the subject composition, containing phenylglyoxal and capable of imparting excellent elasticity such as tenseness and stiffness to hair and sustaining the effects for a long period by treatment one time even by repeating washing of hair, etc. CONSTITUTION:A keratinous fiber treating composition containing 0.01-10wt.%, especially 0.1-5wt.% phenylglyoxal. A method for, e.g. applying the composition to hair, then allowing the hair to stand for a prescribed time and washing off the composition, etc., is cited as a method for using the above-mentioned composition. The hair may be heated to a prescribed temperature during the period of allowing the hair to stand. If the hair is treated after pretreating the hair with a reducing agent, especially a pretreating agent containing thioglycolic acid or its salt, bonding of the phenylglyoxal to the keratinous fiber is promoted to further improve the elasticity imparting effects.
Mushroom enriched weight loss diet. Participants will be given a personalized diet plan, at a calorie level sufficiently restricted to result in a 20 lb weight loss over a period of 6 months, followed by a weight maintenance diet for a further 6 months.
A multi-center sample collection study in patients presenting with pigmented lesion(s) suspicious for melanoma. All suspicious lesions should meet at least one of the "ABCDE" (asymmetry, border, color, diameter, evolving) criteria. Patients will be consented for the study and screened against the inclusion and exclusion criteria. Once the patient is determined to be acceptable for the study they will be assigned a unique patient number and tissue collection will begin. Tissue from the lesion will be collected using DermTech's non-invasive adhesive patch kit according to the instructions for use followed by surgical biopsy. Digital dermoscopy of the lesion is preferred but not required.
PURPOSE:The titled material containing extraction residue of ginseng and/or dishcloth gourd as an essential component. CONSTITUTION:A growth promoting material obtained by washing ginseng and dishcloth gourd [all of DARUMA species (a species of Luffa cylindrica Roem.), Luffa cylindrica Roem., Luffa acutangula Robxg., etc. may be suitably used] at 3:7-7:3 compounding ratio with water, defatting or without defatting both, extracting the mixture with water or a hydrous lower alcohol, e.g. about 50vol% hydrous methanol or ethanol, preferably under heating, fittering off the above- mentioned extract, and separating the extract into a filtrate and extraction residue, distilling away the above-mentioned alcohol, adding an adequate amount of water thereto, subjecting the diluted aqueous solution to adsorption treatment with a monionic adsorbent resin to give a saponin component, using the saponin component for another application, and incorporating the resultant extraction residue as an active constituent therein. The amount of the extraction residue to be used is 5-50wt% for a plant fertilizer and 5-50wt% or 100wt% for an animal feed to give the aimed growth promoting material.
A divisible tablet has a number of readily severable sections 1,2,3 which may be divided accurately and separated into multi-sectional sub units. The tablet comprises a unitary tablet body having a bottom surface 4 with at least a first concavity 6 therein, wherein the tablet further has a second concavity 8 in its upper surface 5, at a location that is longitudinally displaced relative to the first concavity 6. Each concavity may have a score line such as furrows 7,9 to facilitate accurate separation of the tablet subunits. Score lines, such as furrows (17), may also be present in the apices of the tablet to further facilitate accurate separation of the subunits 1,2,3. A compressive force applied to the tablet on the upper surface 5 over the first concavity 6 enables division of the tablet at the first concavity 6 and a compressive force applied to the tablet on the bottom surface 4 over the second concavity 8 enables division of the tablet at the second concavity 8. This enables all divisions to be carried out singlehandedly by pressing the tablet against a support surface and inverting the tablet following the first division. The preferred tablet form has two cavities on the bottom surface and one concavity on the upper surface giving an M-shaped tablet form. The tablet may also suitably be fragmented by squeezing between thumb and forefinger at the appropriate points along the tablet.