anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Detailed Description: Diabetes mellitus and hypertension are two major causes of chronic kidney disease (CKD) that starts as subclinical decline in renal function that silently progresses to symptomatic advanced stages associated with irreversible significant damage of the kidney structure. Recent major improvements in pharmacotherapy of hypertension and diabetes have substantially reduced the prevalence of cardiovascular complications, yet, the frequency of CKD remains largely unchanged. Renal denervation is a new minimally invasive method to create regional blockade of the renal sympathetic nerves that is currently used as non-pharmacological therapy of hypertension. The CKD is likewise mediated by overactivity of renal sympathetic system so that RDN has strong potential to prevent development or progression of CKD. The new anatomically optimized distal RDN may have additional benefit in this regard. Denervation of the distal vessels involved in tonic regulation of renal blood should cause a significant drop in renal vascular resistance and proportional increase in blood and oxygen supply to the kidney preventing/reducing chronic hypoxia of renal tissue that is major mechanism of CKD. The aim of this study is to prove the aforementioned concept. For this purpose the eligible patients with type 2 diabetes mellitus and hypertension will undergo distal renal denervation performed using dedicated radiofrequency catheter Symplicity Spyral. The changes in the kidney function and structure as well as BPs (office and ambulatory) will be assessed at baseline, 6 and 12 months post-procedure
BACKGROUND: With the rapid growth of global aging, frailty has become a serious public health burden, affecting the life quality of older adults. Depressive symptoms (depression hereafter) and sleep quality are associated with frailty, but the pathways in which sleep quality and depression affect frailty remain unclear.
METHOD: This cross-sectional study included 1866 community-dwelling older adults. Demographic characteristics and health-related data of them was collected, and we also assessed frailty, depression, and sleep quality. Descriptive statistics were carried out and ordinal logistic regression analysis was used to identify the factors correlated with frailty. Spearman correlation analysis and mediation analysis were employed to assess associations between sleep quality, depression and frailty. Two-sided p < 0.05 was considered as significant.
RESULTS: The results showed that 4.1% older adults were frail and 31.0% were pre-frail. Ordinal logistic regression showed that age, consumptions of vegetables, exercise, sleep quality, depression, number of chronic diseases, chronic pain, and self-rated health were correlated with frailty. Spearman correlation analysis revealed that frailty was associated with depression and sleep quality. There was a mediation effect that sleep quality was a significant and positive predictor of frailty (total effect = 0.0545, 95% boot CI = 0.0449-0.0641), and depression was a mediator between sleep quality and frailty (mediation effect = 60.4%).
CONCLUSION: Depression and poor sleep quality may be early indicators of frailty in older adults. Improving the sleep quality and psychological state of older adults can improve frailty, which is beneficial for healthy aging.
Chronic pain (CP) affects about 30% of the global population and poses significant challenges to individuals and healthcare systems worldwide. The interactions between physiological, psychological, and social factors are crucial in the onset and development of CP conditions. This study aimed to evaluate the effectiveness of mindfulness-based intervention, examining its impact on perceived stress (PSS), depression and anxiety (BDI-II, PGWBI/DEP, SAS, STAI Y), sleep quality (PSQI), and mindfulness abilities (MAAS) in individuals with CP. Participants (N = 89, 84.3% female) underwent one of two diagnoses [fibromyalgia (FM) or low back pain (LBP)] and took part in an MBSR intervention. The mindfulness program proved effective in reducing PSQI scores (F = 11.97; p < 0.01) over time, independently of the type of diagnosis. There was also a marginal increase in trait mindfulness as measured by MAAS (F = 3.25; p = 0.07) in both groups. A significant difference between the two groups was found for the effect on PSS: F (1,87) = 6.46; p < 0.05. Mindfulness practice also reduced anxiety in FM and depressive symptoms in LBP, indicating a reduction in psychological distress among participants. Our findings suggest that mindfulness-based interventions may offer promising avenues for personalized pain management in clinical settings.
The invention discloses an N-terminal heparin binding domain polypeptide and a C-terminal binding domain polypeptide of a recombinant fibronectin. The N-terminal heparin binding domain polypeptide consists of five I-type homologous structures of the N-terminal of a FN molecule, including 237 aminophenols, which are from Ser46 to Gly282. A DNA sequence which codes the polypeptide is from 403bp to 1113bp with a length of 711bp. A FCR amplified fragment length is 741bp; a fragment length after double digestion is 729bp. A polypeptide molecular weight, which is expressed by barm, is 28.52kDa. The C-terminal heparin binding domain polypeptide consists of three III-type homologous structures of the FN molecule, including 272 aminophenols, which are from Tyr1720 to Tyr1991. The DNA sequence which codes the polypeptide is from 5428bp to 6244bp with a length of 816bp. The FCR amplified fragment length is 835bp; the fragment length after double digestion is 828bp. The polypeptide molecular weight, which is expressed by barm, is 36.09kDa. The invention is applied to medicine preparations for a serious infection of septicemia, a hemorrhage of thrombocytopenia and a disseminated intravascular coagulation.
The invention relates to a traditional Chinese medicine for detoxification, in particular to a medicine for alcohol poisoning. Provides a medicine for solving the alcoholism problem by a simple formula of relieving epigastric distention, reducing phlegm and relieving hangover. The alcohol poisoning medicine comprises old women, fructus Amomi, semen Phaseoli, Glycyrrhrizae radix, rhizoma Zingiberis recens, Sal, flos Caryophylli, fructus Amomi rotundus, and fructus crotonis. The old girl, the condensed sand, the red bean, the liquorice and the ginger are all coarse powder, the clove is chopped clove, the cardamom seed is chopped powder, the croton is not peeled, and the raw materials are strung with iron wire. Decocting the above materials with water, baking, and taking out fructus crotonis for administration after drinking. The medicine adopting the formula can be taken after excessive drinking, on one hand, the medicine can sober up and relieve paralysis of central nerves and restore consciousness, on the other hand, the medicine can widen middle energizer and reduce phlegm, and avoid asphyxia caused by respiratory tract blockage due to excessive phlegm, thereby effectively relieving discomfort caused by alcoholism.
HLA-A2.1 positive patient will receive 3 biweekly intradermal/intravenous vaccination with autologous mRNA transfected mature dendritic cells, followed by a DTH skin test for monitoring purposes. One such cycle is repeated every 6 months if no signs of progression, up to a total of 3 cycles.
PURPOSE: The purpose of this qualitative interview study was to identify themes regarding considerations in the usage of speech amplification device usage for people with Parkinson's disease (PD) and hypophonia from the perspective of speech-language pathologists (SLPs).
METHOD: Eligible participants included SLPs currently practicing in the United States or Canada with experience working with clients with PD for at least 2 years. Ten SLPs participated in 60-min interviews conducted via Zoom. A semistructured interview guide was created prior to the interviews. The interviews were transcribed following their completion, and an iterative coding process was used to identify themes using thematic analysis.
RESULTS: Three main themes were identified from the interviews. The first theme encapsulated how clinicians described amplification devices as a potential treatment tool, which highlighted the nuances that may impact selecting an amplification device as a treatment option such as increased hypophonia or dysarthria severity and cognitive decline. The second theme highlighted how device selection depends on the individual needs of the user. Individual client characteristics (such as disease symptoms and individual needs and preferences) may impact the choice of amplification device. The last theme outlined the importance of involving family members in all stages of device use and involving other health care team members on a case-by-case basis.
CONCLUSIONS: The insights provided by the SLP participants help to understand the clinical decisions that are made when determining device candidacy, selecting a device, and evaluating device success. These insights can be used to improve research studies of augmentative management of hypophonia and guide more personalized management decisions.
Participants will attend 90-minute ERP + improv group therapy sessions for 12 consecutive weeks. They will also complete homework between sessions, answer questions, and complete questionnaires.
This invention relates to remedy for hypertension. It eliminates the restricted indication in the cases with elevated intracranial pressure in the acute stage of cerebral attack. The nicardipine or its salt has been contraindicated. For the first time, it is found out that in cerebral infarct model rats, nicardipine or its salt does not affect the intracranial pressure. That is different from the common recognition. Even though a group with elevated intracranial pressure in the acute stage of onset. Namely, a remedy for hypertension for patients with elevated intracranial pressure in the acute stage of cerebral attack. It comprises nicardipine or its salt as the active ingredient.
Tuberculosis was declared a global emergency by the World Health Organization (WHO) in 1993. The global problem of tuberculosis is further complicated by a substantial increase in drug resistant tuberculosis. Available data suggest that drug resistant TB especially multi drug resistant may represent a public health threat in areas with a high prevalence of tuberculosis, suboptimal TB control programmes and/ or HIV. The cure rate of these cases has been reported to be lower than for non-drug resistant TB with a failure rate of 44%. New therapies for MDR-TB have not been introduced since the fluoroquinolones in the 1970s. Strains of Mycobacterium Tuberculosis (M. tub.) in H resistant cases often contain mixture of susceptible \& resistant organisms. Use of high dose H (16- 20 mg/kg) can eliminate susceptible \& those with low level resistance4. This Study was done to evaluate the role of isoniazid (INH) at high \& normal dosages as an adjuvant therapy in treatment of patients with persistent culture positive pulmonary tuberculosis despite 6 months of continuous first line antitubercular treatment and on culture at least resistant to isoniazid and rifampicin.
MBTI treatment will involve a standardized 6-session intervention which integrates the mindfulness training and exercises from mindfulness-based stress reduction (MBSR) with behavioral strategies based on sleep restriction therapy and stimulus control delivered within the context of mindfulness principles. Mindfulness principles include: 1) increase awareness of the mental and physical states that promote sleep (i.e., sleepiness), 2) shift sleep-related metacognitions to reduce hyperarousal, and 3) promote a mindful stance to respond when symptoms of insomnia arise. An overview of the treatment program, sleep education, and an introduction to the principles of mindfulness meditation is given (week 1). Then a combination of mindfulness meditations, sleep restriction, and stimulus control is conducted (week 2-6).
Pneumatic tourniquet (PT) is frequently used in extremity surgeries because of its advantages, including better surgical field visibility and shorter operation duration. Notwithstanding its advantages, PT can cause a number complications in the postoperative period, including pain, edema, skin complications, muscle injuries, thromboembolism, and neurological damage. Although the risks associated with the use of PT have decreased because of the introduction of adjustable pressure mechanisms and safety alarm systems, complications can still occur. Surgical team members should be knowledgeable about PT to ensure quality and safe patient care. It is of great importance to evaluate the size and shape of the extremity and skin condition prior to PT application, apply the appropriate size cuff, and evaluate the skin under the cuff and peripheral pulses distal to the cuff upon application.

There are different recommendations regarding safety practices for the application of PT in extremity surgeries. Previous studies in the relevant literature reported controversial results regarding the appropriate tourniquet cuff pressure for extremity surgery, and there are different applications for determining the cuff pressure. Previous studies mostly used standard tourniquet pressure (STP). STP is defined as 250 mmHg pressure for the upper extremity and 300 mmHg pressure for the lower extremity. Nevertheless, minimum inflation pressures have been recommended instead of STP to prevent complications likely associated with high pressures. Another method is the use of limb occlusion pressure (LOP). LOP is defined as the minimum pressure required to stop arterial blood flow into the extremity distal to the cuff. LOP can be determined manually or automatically by slowly inflating the cuff and stopping the pulse using certain equipment, including a Doppler flowmeter or pulse oximeter. It was suggested that PT cuff pressure could be minimized by LOP application and that the risk of tourniquet-related complications could be reduced. Most previous studies on PT have focused on the lower extremities. Nevertheless, tourniquet use also been the method of choice in upper extremity surgery to provide a surgical field without blood.

In PT applications, protective padding material (PPM) is placed between the skin and the cuff to prevent skin injuries. The Association of Perioperative Registered Nurses recommends the application of soft, low-lint padding materials, including limb protection sleeves or two layers of stockinette (plaster stocking). The padding material should not compress the skin or cause wrinkles. Fewer skin complications were observed in patients with cotton pads or elastic stockinette than in patients without PPM. There is no material with proven superiority in the use of PPM.

This study investigated the effects of cuff pressure level and the choice of PPM on the prevention of skin complications after PT in upper extremity surgery. It was hypothesized that there was a relationship between the level of cuff pressure and the PPM during use and skin complications during PT applications in upper extremity surgery.
Procedure for the preparation of 3 (o 5) -formulpirazol-4-carboxylates of alkyl. Consists of the following stages: 1. Selective reduction in the pirazoldicarboxilato alkyl of the alcoxicarbonilo group in position 3 (or 5), in conditions that do not alter the ester group in position 4, which is effected by treatment with lithium or aluminum hydride in a solvent, such as ethyl etheric, tetrahydrofuran or dimethyl ether of dietilenglycol, at temperatures between 20 and 80ºc during periods of time that rock between ninety minutes and five hours, which gives them a 3 (or 5) -hydroxymetilpirazole-4 -carboxylate of alkyl. 2. Oxidation of the product obtained in the previous stage, with reagents such as trioxide of bromine/pyridine, active manganese bioxide, nitrate, cereal amymic nitrate and other similar. T (Machine-translation by Google Translate, not legally binding)
Per- and polyfluoroalkyl (PFAS) substances are a large group of chemicals with elevated water and oil-resistance properties, widely implicated in various applicative fields. Due to the extensive use and high resistance to degradative factors, these compounds pose a significant risk of environmental spreading, bioaccumulating also in living organisms. In this context, despite many researches have been performed to demonstrate "legacy" PFAS harmfulness, only few data are still available about all the emerging fluorinated molecules, industrially introduced to replace the previous ones. For this reason, we proposed the medicinal leech Hirudo verbana as consolidated invertebrate model to assess the effects of four different PFAS (HFPO-DA, PFMoBa, PFOA and PFMOPrA) following freshwater dispersion. Morphological, immunohistochemical and molecular analyses demonstrate that, despite all the compounds basically induce an acute inflammatory and oxidative stress response, a different cellular and molecular response has been observed. Whereas for PFOA and PFMOPrA an increase in the tested concentration leads to a corresponding rise in the immune response, HFPO-DA and PFMoBa trigger an entirely opposite effect. Indeed, the significant recruitment of both granulocytes and macrophage like cells, typically involved in the removal of non-self, is inhibited with increasing concentrations of these compounds. The data collected revealed a different sensitivity of the leech immune system following PFAS exposure, requiring to deepen the current knowledge on the potential toxicity of these compounds.
PURPOSE:The titled coating material capable of preventing effectively adhesion or build-up of food, having improved durability, comprising a nonadherent substance powder and a resin curable by ultraviolet light radiation. CONSTITUTION:A nonadherent substance (e.g., fuorine-contained resin such as polytetrafluoroethylene, etc., silicone resin, etc.) powder is uniformly dispersed into an ultraviolet-curing resin. The prepared mixture is applied to the artificial dentis 1 and the denture base 2, irradiated with ultraviolet rays, the resin is cured, to form a coating layer consisting of the cured layer 4 of the resin wherein the part 3 of the nonadherent substance powder is embedded and the part 3' is protruded on the surface of the artificial dentis and the denture base. The existence of the powder 3' protruded from the surface of the cured layer 4 prevents effectively adhesion and built-up of food. The existence of 15-20wt% nonadherent substance component provides the best result.
PROBLEM TO BE SOLVED: To purify the subject compound in an industrial scale and simple and sure manner by carrying out crystallization on cooling surface on which crystals of an imidazole compound are grown. SOLUTION: In a method for purifying either one of an imidazole of formula I (R<1> to R<4> are each H, a halogen, acetyl, carboxyl, a 1-20C alkyl, a 6-12C aryl, etc.), and an effective substance containing the imidazole as a base by crystallization, the crystallization is carried out on at least one cooling surface on which crystals of imidazole compound grows. The effective substance containing the imidazole as a base includes e.g. secnidazole of formula II or climbazole of formula III. In the purification, crystals of imidazole compound which grows on the cooling surface are preferably brought through the cooling surface into contact with a liquid mixture (preferably containing at least 80 wt.% imidazole compound) of a substance containing an imidazole compound to be purified and the cooling surface is cooled to form the corresponding crystals.
Provided is a method, system, and computer program product for analyzing an electronic health record (EHR) using robotic process automation (RPA). A processor may analyze an EHR associated with a user. The processor may identify, based on analyzing the EHR, one or more health parameters that are outside of a threshold range. The processor may determine a set of recommended actions that may be performed to cause the health parameter to fall within the threshold range. The processor may analyze activity data associated with the user. The processor may identify, based on the activity data, a set of known activities performed by the user. The processor may correlate the recommended actions with the known activities to identify a subset of personalized actions that are specific to the user. The processor may send the subset of personalized actions to the user.
The waiting list control group initially receives no treatment, but do weekly screenings. After 9 weeks, the control group receives the same treatment as the other study arm.
The World Health Organization Ensuring Quality in Psychological Support program is currently developing a Universal Foundational Helping Skills Training package. This training package will be freely available for use by all health professionals and other service providers seeking to develop basic skills in mental health and psychosocial support. These foundational helping skills are based upon common factors in the mental health and psychological services, which have been widely researched and identified as essential and universal prerequisites for the effective delivery of any psychosocial or psychological components in health interventions. These are also foundational skills are also part of the competencies for non-specialists to deliver psychological interventions in global mental health. Competent use of these skills by providers improves outcomes for people accessing all fields of health services--ranging from surgery to pain clinics--support greater treatment adherence. A foundational helping skills training curriculum is needed to promote competency in the provision of warm and trusting relationships between health care providers and people accessing health services. Other foundational helping skills include rapport building, the demonstration of empathy, using culturally or age-appropriate terminology and concepts for distress, and ensuring communication of hope. This training guidance will fill the gap many training programs for providers who are not mental health specialists, and the training guidance will be feasible for implementation in low-resource settings. The training will be aligned with the World Health Organization competency framework for the health sector that is under development, which stipulates foundational helping skills as essential for all health cadres. The World Health Organization Universal Foundational Helping Skills Training package has the potential to improve competency for basic mental health and psychosocial support services delivered by any health cadres. This training package, alongside other quality improvement activities, will lead to more effective delivery of quality care for clients and will be one step closer to achieving the global communities' and World Health Organization's goal of universal health care. The goal of this study is to conduct a mixed-methods evaluation of the Foundational Helping Skills curriculum by observing outcomes for trainees in the program who not have prior mental health and psychosocial support skills training.