anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cullen´s sign and Grey Turner sign are, respectively, the cutaneous ecchymoses located in periumbilical region and tissues flanks along the lower portion of the abdomen. Both have been observed in <1% of individuals with acute pancreatitis, suggesting poor prognosis in terms of gravity and mortality. However, these signs are not exclusive for acute pancreatitis, as they can appear in other identities such as: ruptured ectopic pregnancy, aortic aneurysm, rectus abdominis muscle hematoma, perforated duodenal ulcer, common bile duct rupture and biliary peritonitis, idiopathic perirenal hemorrhage, infectious mononucleosis with splenic rupture, metastatic esophageal and thyroid cancer, non-Hodgkin lymphoma, amoebic liver abscess, portal hypertension, and liver tumor disease. Based on the review of the literature, it is patent that Cullen´s sign and Grey Turner sign are neither sensitive nor specific for acute pancreatitis, therefore it may be best to relate these findings in the physical examination to conditions associated with abdominal pathology and retroperitoneal hemorrhage. We report the case of a 60-year-old Spanish female, with previous history of squamous small cell neuroendocrine lung carcinoma with hepatic extension in follow-up by palliative care services. Due to disease progression after two palliative chemotherapy sessions, the patient came to the emergency room with jaundice and abdominal pain in superior regions. On physical examination, notable findings included ecchymoses in the right flank and periumbilical region. Laboratory findings showed elevated bilirubin and transaminase levels, as well as a small increase in the serum amylase and lipase levels. Cholangioresonance was performed to discard acute biliary pancreatitis. The imaging revealed no enlargement of the pancreas, dilatation of the common bile duct without visible stone, and a liver full of new cancerous liver implants. These findings were consistent with diffuse distribution metastases lesions, concluding the progression of liver disease.
This is an open label, randomized, interventional study indented to find the efficacy of different treatment regimens in treatment of pulmonary hypertension secondary to lung disease and/or hypoxia. It involves 3 arms, one getting monotherapy with sildenafil for 6 months, 2nd getting bosentan monotherapy initially for 3 months and then combination of sildenafil and bosentan for 3 months, 3rd getting combination sildenafil and bosentan from the beginning for 6 months. The aim is to decide when is the best time to start combination therapy either from start or at the time of drug failure. Improvement will be assessed by change in functional class, pulmonary pressures measured by ECHO, pulmonary function test, six minute walk test and biochemical markers. Lack of randomized trials and Indian data is there on the subject. Also adverse events and serious adverse events will be closely monitored and reported to the ethics committee and DCGI immediately.
A skin care composition for improving the appearance of the skin. The skin care composition comprises petroleum jelly, a vegetable oil blend and an antioxidant. The concentration of the vegetable oil blend in the composition is at least 50% (v/v). In some embodiments, the vegetable oil blend comprises apricot oil, coconut oil, jojoba oil and argan oil. In some embodiments, the vegetable oil blend further comprises castor oil and vegetable glycerin oil. The skin care composition may optionally further include an essential oil such as lavender oil and a substance from the plant of the Aloe genus.
South Africa has one of the highest child mortality and stunting rates in the world. Flexible geoadditive models were used to investigate the geospatial variations in child mortality and stunting in South Africa. We used consecutive rounds of national surveys (2008-2017). The child mortality declined from 31 % to 24 % over time. Lack of medical insurance, black ethnicity, low-socioeconomic conditions, and poor housing conditions were identified as the most significant correlates of child mortality. The model predicted degrees of freedom which was estimated as 19.55 (p < 0.001), provided compelling evidence for sub-geographical level variations in child mortality which ranged from 6 % to 35 % across the country. Population level impact of the distal characteristics on child mortality and stunting exceeded that of other risk factors. Geospatial analysis can help in monitoring trends in child mortality over time and in evaluating the impact of health interventions.
PURPOSE:To provide the title biocompatible filler especially excellent in sealing ability, comprising a unsaturated carboxylic acid polymer solution as curing liquid and a powdery agent composed of tricalcium alpha-phosphate powder, magnesium oxide powder and iodoform powder. CONSTITUTION:The objective filler comprising (A) a powdery agent pref. <=20mum in particle size composed of (1) 100 pts.wt. of tricalcium alpha-phosphate powder, (2) 2-12 pts.wt. of magnesium oxide powder and (3) 5-60 pts.wt. of iodoform powder and (B) a curing liquid, a 10-40wt.% solution of a unsaturated carboxylic acid polymer (pref. acrylic acid homopolymer or a copolymer of acrylic acid and a small amount of itaconic acid, maleic acid etc.) at the weight ratio A/B=1.0-2.5. The present filler is free from bioirritability and excellent in the adhesivity to gutta-percha points and in operability, being effective for root canal-filling therapies using, in particular, its combination with gutta-percha points.
Hepatitis B virus (HBV) is responsible for the most common form of parenterally transmitted viral hepatitis. It is estimated that approximately 350 million people worldwide are persistent carriers of the virus and it is a major cause of acute and chronic infections of the liver, with significant associated morbidity and mortality. Chronic infection occurs in 98% of new-born children infected by vertical transmission from the mother and in 5% of individuals infected after 2 years of age. About 25% of these subjects will progress to cirrhosis and 20% of this subgroup will develop hepatocellular carcinoma - one of the most common cancers world wide. HBV is a non-cytopathic virus and liver injury is mainly mediated by the host immune response against virus-infected liver cells and by the production of inflammatory cytokines. A vigorous, polyclonal and multispecific cytotoxic and helper T cell response to HBV is readily detectable in the peripheral blood of subjects with acute self-limited hepatitis B, but is weak, antigenically restricted (mono- or oligospecific) or undetectable in subjects with chronic infection. A vigorous T cell response is thus believed to be responsible for the elimination of the hepatitis B virus. The aim of a therapeutic vaccine would be to enhance natural responses by boosting the appropriate cellular immune response to HBV. The purpose of this study is to evaluate the safety and tolerability profile of the pPDPSC18 DNA vaccine as administered by Particle Mediated Epidermal Delivery (PMED )
Use of either 1. Enzalutamide and dutasteride or 2. Enzalutamide and finasteride.
Patients referred to the motherhood out-patient clinic because of fear of childbirth. No intervention. Followed up by three questionnaires (when recruiting, just after the delivery and 6 months after the delivery).
BACKGROUND: The implantable cardioverter-defibrillator (ICD) prevents sudden cardiac death in patients with ischemic cardiomyopathy (ICM). Catheter ablation has been shown to effectively reduce ventricular tachycardia (VT) recurrence, yet its efficacy in patients without an ICD implantation remains uncertain.
OBJECTIVE: We aimed to investigate the outcomes of ablation for VT in patients with ICM without a backup ICD.
METHODS: Patients with ICM who received ablation for VT without an ICD implantation were included in this study. Ablation was guided by either activation mapping or substrate mapping. Endocardial ablation was the primary strategy; epicardial access was considered when endocardial ablation failed. The primary end point was VT recurrence during follow-up; secondary end points included cardiovascular rehospitalization, all-cause mortality, and a composite of these events.
RESULTS: A total of 114 patients were included, with the mean age of 58.2 ± 11.1 years, 102 of whom (89.5%) were male. Twelve patients (10.5%) underwent endo-epicardial ablation, whereas the rest received endocardial ablation. With a median follow-up of 53.8 months (24.8-84.2 months), VT recurred in 45 patients (39.5%), and 6 patients (5.3%) died, including 2 sudden cardiac deaths. The recurrence rate of VT was significantly lower in patients undergoing endo-epicardial ablation than in those with endocardial ablation only (8.3% vs 43.1%; log-rank P = .032). After multivariate adjustment, epicardial ablation remained associated with a reduced risk of VT recurrence (hazard ratio, 0.14; 95% confidential interval, 0.02-0.98; P = .048).
CONCLUSION: Patients with ICM undergoing VT ablation without a backup ICD experienced a notably low rate of arrhythmic death. Most recurrences proved nonlethal.
The invention relates to the field of traditional Chinese medicines, and discloses an antioxidant traditional Chinese medicine composition and application thereof, wherein the antioxidant traditional Chinese medicine composition comprises the following components in parts by weight: 45-90 parts of lucid ganoderma extract, 30-60 parts of ginseng extract, 55-120 parts of red sage root extract, 35-72 parts of kudzuvine root extract, 60-120 parts of gynostemma pentaphylla extract and 25-55 parts of szechuan lovage rhizome extract. According to the aim of 'qi is the general of blood and qi can promote blood circulation', ginseng, ganoderma lucidum and gynostemma pentaphylla tonify qi and strengthen the body resistance, and blood mobility is enhanced. The root of red-rooted salvia, kudzuvine root and szechuan lovage rhizome activate blood circulation to dissipate blood stasis and promote blood circulation. All the products are used together to play the roles of tonifying qi, strengthening body resistance, tonifying qi, promoting blood circulation, removing blood stasis and dredging collaterals. The middle warmer is filled with food, and the food is not stagnated; the powder has the effects of tonifying, and the powder does not hurt the healthy energy; complement each other. The traditional Chinese medicines are reasonable in compatibility and synergistic, and have remarkable antioxidation function. In addition, the antioxidant Chinese medicinal composition can improve cerebral ischemia, improve cerebral vasomotor dysfunction and improve the anti-apoptosis capability of brain tissues.
Video discharge instructions developed using Easy Sketch Pro3TM software (Easy Sketch Pro, United Kingdom). It was created by the primary and co-investigator based results on a focus group consisting of two paediatric residents, two paediatric emergency medicine fellows, a paediatric emergency medicine nurse, and a paediatric emergency medicine staff physician.
BACKGROUND: Evidence linking ozone to depression and anxiety disorders remains sparse and results are heterogeneous. It remains unknown whether omega-3 fatty acid, or genetic susceptibility of mental disorders modify the impacts of ozone. The aim is to assess the associations of ambient ozone with depression and anxiety, and further explore the potential modification effects of omega-3 fatty acid and genetic susceptibility.
METHODS: In total of 257,534 participants were enrolled from 2006 to 2010 and followed up to 2016. Depression and anxiety were assessed using mental health questionnaires, primary care records and hospital admission records. The annual average concentrations of ozone were calculated and linked to individuals by home address. Dietary intake and plasma concentration were selected to reflect levels of omega-3 fatty acid. Polygenetic risk scores were selected to reflect genetic susceptibility. We examined the associations of ozone and incident mental disorders, and potential modification of omega-3 fatty acid and genetic susceptibility.
RESULTS: Incidences of depression (N = 6957) and anxiety (N = 6944) was associated with increase of ozone. Higher levels of omega-3 fatty acid might attenuate the ozone related depression risk. However, the modification effects of genetic susceptibility were not found.
CONCLUSIONS: Long-term exposure to ambient ozone increase the risk of mental disorders among the middle aged and older adults, and omega-3 fatty acid could reduce the adverse effects of ozone on mental health. Higher intake of omega-3 fatty acid is a potential strategy to prevent the risks caused by ozone on public mental health.
Seven questionnaires regarding symptoms and quality of life completed at baseline, at follow up, and again in one month. Participants receive EEG at baseline, 1 week after neurofeedback group completes sessions, and again in one month.
An agent for dying (e.g. coloring) keratinous material, in particular human hair, is disclosed. The agent comprises (a1) at least one alkyl (poly)glycoside, (a2) at least one pigment, and (a3) at least one amino-functionalized silicone polymer. A process for dyeing keratinous material with the agent is also disclosed. The process comprises preparing an application mixture comprising, applying the application mixture to keratinous material for a time sufficient to expose the keratinous material to the agent, and then rinsing the application mixture from the keratinous material with water. A multicomponent packaging unit (kit-of-parts) for dyeing keratinous material with the agent is also disclosed.
The invention relates to a cancer-related tumor specific transcript MARCO-TST and application thereof. The invention discloses a novel MARCO Transcript named MARCO-TST (MARCO-Tumor Specific Transcript). The amino acid sequence of the MARCO-TST polypeptide is shown as SEQ ID NO. 1. MARCO-TST is specifically expressed in triple negative breast cancer cells and is not expressed in normal tissues. The MARCO-TST has a new transcription start site, and the protein coded by the MARCO-TST has a new sequence at the N-terminal. Downregulating the expression of MARCO-TST significantly inhibited the proliferation and metastatic potential of tumor cells in vitro and in vivo. MARCO-TST can be used as a target molecule for novel tumor diagnosis and treatment.
BACKGROUND: Colorectal cancer (CRC) is the third highest incidence cancer and is the leading cause of cancer mortality worldwide. Metastasis to distal organ is the major cause of cancer mortality. However, the underlying genetic factors are unclear. This study aimed to identify metastasis-relevant genes and pathways for better management of metastasis-prone patients.
METHODS: A case-case genome-wide association study comprising 2677 sporadic Chinese CRC cases (1282 metastasis-positive vs 1395 metastasis-negative) was performed using the Human SNP6 microarray platform and analysed with the correlation/trend test based on the additive model. SNP variants with association testing -log10 p value ≥5 were imported into Functional Mapping and Annotation (FUMA) for functional annotation.
RESULTS: Glycolysis was uncovered as the top hallmark gene set. Transcripts from two of the five genes profiled, hematopoietic substrate 1 associated protein X 1 (HAX1) and hyaluronan-mediatedmotility receptor (HMMR), were significantly upregulated in the metastasis-positive tumours. In contrast to disease-risk variants, HAX1 appeared to act synergistically with HMMR in significantly impacting metastasis-free survival. Examining the subtype datasets with FUMA and Ingenuity Pathway Analysis (IPA) identified distinct pathways demonstrating sexual dimorphism in CRC metastasis.
CONCLUSIONS: Combining genome-wide association testing with in silico functional annotation and wet-bench validation identified metastasis-relevant genes that could serve as features to develop subtype-specific metastasis-risk signatures for tailored management of patients with stage I-III CRC.
NEW MATERIAL:1-Benzoyl-3-piperidinyl ester or methyl ester of 2,6-dimethyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid of formula I. USE:An intermediate for synthesis of compounds having angiectatic action and antihypertensive action and useful as a drug for circulatory organs. PREPARATION:According to the reaction formula, compounds of formulae III, IV and V are reacted in an inert solvent (e.g. methanol, ethanol, n-propanol or isopropanol) to obtain the objective compound of formula I. For the above- mentioned reaction, the compounds of formulae III, IV, V are suitably used in an equivalent ratio of (0.7:1:0.7)-(1.4:1:1.4). The reaction temperature is 40 deg.C, preferably 60 deg.C to boiling point of the used solvent.
FIELD: experimental medicine, immunology. SUBSTANCE: invention relates to stimulation of immunological resistance in tuberculosis infection. Method involves administration of 2% solution of coal tar in animals infected with virulent strain of tuberculosis mycobacteria. This solution is applied on skin in combination with oral administration of sodium glutamate and taurine for month, not less. EFFECT: enhanced resistance of body, among them at background of unfavorable factors of environment. 2 tbl, 7 ex
Topical application of one drop of silver diamine fluoride 38% to active untreated roof surface caries, lesions at the furcation, or lesions at crown margins. Application was repeated once each six months.
PCT No. PCT/EP93/02168 Sec. 371 Date May 19, 1995 Sec. 102(e) Date May 19, 1995 PCT Filed May 19, 1995 PCT Pub. No. WO94/06419 PCT Pub. Date Mar. 31, 1994A process is provided for the production of a flat administration form with a dosable portion of drugs or of a flat-shaped device for the dosable release of volatile substances, such as aromatic substances, to the ambient air by using high-volatile or thermolabile dosing media in liquid or semisolid state as the ingredients of the administration form or of the device by means of printing processes. A free-flowing preparation of the ingredients is knife-coated in a measured amount into at least one volumetrically defined cavity of a flat printing block. A substrate to be charged with the ingredients or dosing media, respectively, is gradually led as web-shaped material under web tension over the cavity of the printing block and pressed into the filled cavity by means of a mechanical pressure device whereby the substrate takes up the ingredient from the printing block in a dosed amount.
Patients with chronic obstructive pulmonary disease (COPD) have reduced exercise tolerance. One mechanism for this is thought to be due to dynamic hyperinflation during exercise (an increase in the end-expiratory lung volume) that contributes to the sensation of breathlessness. Whether this also contributes to inhibiting motor recruitment, and reduces the available power output (termed performance fatigue; PF), is not well understood. Preliminary data suggests that many COPD patients, unlike healthy subjects, stop exercise with a 'skeletal muscle power reserve' i.e. the ability to acutely increase muscle power output. This suggests that they are limited in the exercise task by mechanisms other than acute intramuscular limitations to power production (termed muscle fatigue; MF). Exercise tolerance is increased by treatment with the fixed-dose combination bronchodilator, STIOLTO™ RESPIMAT®. We hypothesize that increased exercise tolerance with STIOLTO™ RESPIMAT® (reduced performance fatigue; PF) will be mediated by a combination of: 1) reduced inhibition of muscle activation (termed activation fatigue; AF) allowing patients to drive their leg muscles harder, and thus; 2) increased muscle fatigue (MF).
Tobacco use and obesity are the two leading causes of preventable deaths. Because these two behaviors share common brain reward mechanisms, reducing one behavior often leads to increases in the other behavior. Behavioral Economic and Incentive Salience models shed much light on this clinical problem. Smoking cessation produces reward dysregulation that can alter the motivational salience of other reinforcers, particularly food. After stopping smoking, smokers increase between-meal snacking, especially foods high in fat and sugar. Increases in caloric intake occur within days of quitting smoking, and are clinically significant. The investigators have also shown that smoking cessation produces working memory deficits and reduces activity in the brain's cognitive control circuits, making it even more difficult to exert self-control over temptations to eat highly rewarding foods. Thus, smokers have a double challenge: food becomes more salient and reinforcing at a time when their neurocognitive resources are compromised.

Neuroimaging can identify mechanisms underlying behavior change beyond self-report and behavioral measures. The proposed functional magnetic resonance imaging (fMRI) study breaks new ground by integrating concepts and tools from the fields of behavioral economics and cognitive neuroscience to accelerate the study of mechanisms underlying PCWG. The investigators will use a previously validated within-subject crossover neuroimaging study design to examine changes in working memory, food salience (cue-induced craving), and food reinforcement processes in the brain after 4 days of smoking cessation (vs. smoking as usual). A non-smoker control group will provide insight into baseline differences from smokers (abstinent and satiated). Caloric intake, the primary outcome, will be assessed using 24-hr. food recalls during each study period. The investigators will assess three parallel pathways including: working memory, food cue reactivity, and food reinforcement at the neural and behavioral levels.

This study will provide new insights about how the brain can constrain or promote the ability of smokers to prevent post cessation weight gain (PCWG) and lead to new interventions that integrate neural and behavioral framework. Support for our predictions would inform testing of novel approaches to prevent PCWG, such as computerized neurocognitive exercise training to increase DLPFC activity and shift activity away from reward sensitive brain networks.
Both hydroxychloroquine 200 mg/tab and sirolimus 1 mg/tab are pills each are taken 2 tablet orally once daily(QD) for 2 cycles . Each treatment cycle is 28 days.
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivative of 3-aryl-2-hydroxypropionic acid, namely, to (S)-2-ethoxy-3-4-[2-(4-methanesulfonyloxyphenyl)ethoxy] phenyl-propionic acid of the formula (I)  . Invention describes methods for preparing compound, intermediate substance used in synthesis, pharmaceutical preparation based on compound of the formula (I). Invention relates also to pharmaceutically acceptable salts, crystalline forms and solvates of compound of the formula (I). Compound is adapted for prophylaxis and/or treatment of clinical states associated with reduced sensitivity to insulin and associated with the latter metabolic disorders. EFFECT: improved preparing method, valuable medicinal properties of compound. 18 cl, 2 ex