anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The special intervention (SI) arm addresses glycemic control, medication adherence, control of modifiable CVD risk factors, health behavior change, and psychosocial and cultural barriers to self-management. The SI arm consists of a collaborative care team approach with four main elements including: 1) Specialized clinical care by a medical provider; 2) Specialized behavioral health care by a behavioral health provider; 3) Group-based chronic disease self-management education by peer-leaders; 4) Intensive, proactive care coordination facilitated by a patient registry and electronic health records.
Patients receive thiotepa IV over 2 hours on days -7 to -5, cyclophosphamide IV over 1 hour on days -5 to -2, and G-CSF SC or IV beginning on day 0 and continuing until blood counts recover. Following clinical recovery from initial myeloablative therapy, patients also receive melphalan, etoposide, and carboplatin as in Arm A. Patients undergo autologous PBSCT on day 0.
<P>PROBLEM TO BE SOLVED: To provide a core material for a writing utensil which can be used for pigment ink as well and is excellent in writing feelings, and the writing utensil.  <P>SOLUTION: The core material for the writing utensil is made of a tubular sintered core, which is composed by sintering a PE powder granule having an ultra-high mol.wt. low pressure polymerization polyethylene (PE) with molecular weight of one million or more, a particle size of 20-250 μm, and a bulk density of 0.2-0.5 g/cm<SP>3</SP>and whose tip is closed, and a fiber core of which the tip part has a shape capable of inserting into the sintered core. Each number shows as follows. 1 is the sintered core. 2 is a relay core. 8 is a pen holder. 81 is an air hole provided to the pen holder. 9 is a cap. 10 is the core for holding ink.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It caused over 2.47 million deaths through various syndromes such as acute respiratory distress, hypercoagulability, and multiple organ failure. The viral invasion proceeds through the ACE2 receptor, expressed in multiple cell types, and in some patients caused serious damage to tissues, organs, immune cells, and the microbes that colonize the gastrointestinal tract (GIT). Some patients who survived the SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae of COVID-19 (PASC). Diagnosis of these patients has revealed multiple biological effects, none of which are mutually exclusive. However, the severity of COVID-19 also depends on numerous comorbidities such as obesity, age, diabetes, and hypertension and care must be taken with respect to other multiple morbidities, such as host immunity. Gut microbiota in relation to SARS-CoV-2 immunopathology is considered to evolve COVID-19 progression via mechanisms of biochemical metabolism, exacerbation of inflammation, intestinal mucosal secretion, cytokine storm, and immunity regulation. Therefore, modulation of gut microbiome equilibrium through food supplements and probiotics remains a hot topic of current research and debate. In this review, we discuss the biological complications of the physio-pathological effects of COVID-19 infection, GIT immune response, and therapeutic pharmacological strategies. We also summarize the therapeutic targets of probiotics, their limitations, and the efficacy of preclinical and clinical drugs to effectively inhibit the spread of SARS-CoV-2.
In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. The adequate blood need to be full with canal space and below the CEJ, then wait for 10-15min to coagulate.
Gemcitabine 1000 mg/m2 i.v. at days 1, 8, 15 of every 28-day cycle. Chloroquine 100 mg, 200 mg or 300 mg (according to dose level) p.o. at days 2, 9, 16 of every 28-day cycle.
PROBLEM TO BE SOLVED: To provide a vacuum impregnation method for rearing and growing hairs so that activating the hair roots is likely encouraged, and hair caps and a unit to be used therefor, by feeding a hair growing agent to the hair roots by impregnation enough into the deep ends of the pores. SOLUTION: This vacuum impregnation unit 1 is provided with a hair cap 10, an air-permeable head band 18, two vacuum pumps P1 , P2 and a chemical solution tank 38. To each of an exhaust vent 15 and an injection mouth 16 and a sucking mouth 17 of the hair cap 10, an exhaust hose 32, a chemical solution feed hose 43 and an air suction hose 31 are connected. The air suction hose 31 is provided with a vacuum release valve 40. The hair cap 10 is set onto a head to keep the scalp at a vacuum, through which the air in the pores s sucked outside, and the components composing the coat layer are thus removed. After then injecting a chemical solution as a hair growing agent into the hair cap 10 and diffusing it in a mist form, opening the vacuum release valve 40 injects the hair growing agent together with the inflow air to penetrate into the pores.
Prior to a planned course of radiotherapy, which will last for eight and a half weeks, 10 weeks of hormonal therapy are given. The hormonal therapy will start with a daily pill called Casodex. Three to seven days after starting this pill, a Zoladex injection will be administered in addition to the Casodex pill. Zoladex hormonal therapy is given in the form of a monthly injection. After 10 weeks from the initiation of hormone therapy, you will begin external radiotherapy. For these treatments only 42 treatment sessions are given. The total dose of radiotherapy delivered during these 8.5 weeks is 75.6 Gy. The hormone injections continue during the radiation treatments and for 2 years after the radiation treatments. The pills are only taken for the 10 weeks before and also during the radiation treatments, however afterwards the pills are discontinued.
The clinical characteristics of open hernia repair under local nerve block guided by ultrasound and epidural anesthesia under daytime surgery mode were compared and analyzed, and the safety, rationality and effectiveness of tension-free repair of inguinal hernia in elderly patients under local nerve block guided by ultrasound were discussed. The clinical data of 200 patients who underwent inguinal hernia day surgery in Liaocheng People's Hospital Affiliated to Shandong First Medical University from January 2022 to October 2022 were retrospectively analyzed, including 150 patients who underwent local anesthesia block surgery and 50 patients who underwent epidural surgery. The visual analog score of the ultrasound local anesthesia group was lower than that of the epidural surgery group at 4 h after operation. The time of getting out of bed and postoperative exhaust were shorter than those of epidural operation group. The recovery rate of unrestricted activity 2 weeks after surgery was higher than that in epidural surgery group (P < 0.05). The incidence of postoperative acute urinary retention between the two groups was lower in local ultrasound anesthesia group, and the difference was statistically significant (P < 0.05). The median follow-up time was 4(1-6) months, and the follow-up rate was 100%. Postoperative complications were seroma, wound infection, chronic pain and recurrence, and there was no statistical significance between the two groups (P > 0.05). No serious complications occurred in both groups. Compared with open epidural surgery, ultrasound-guided local nerve block tension-free day surgery in the elderly has the advantages of less pain, faster recovery, and is safe and feasible.
Maintenance Therapy: Once a complete hematologic remission is obtained, maintenance therapy is considered essential. Maintenance doses will vary from patient to patient. The usual daily maintenance dose of mercaptopurine is 1.5 to 2.5 mg/kg/day as a single dose. It is to be emphasized that in pediatric patients with acute lymphatic leukemia in remission, superior results have been obtained when mercaptopurine has been combined with other agents (most frequently with methotrexate) for remission maintenance. Mercaptopurine should rarely be relied upon as a single agent for the maintenance of remissions induced in acute leukemia. 

Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published. 1-8

There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate. 

Dosage with Concomitant Allopurinol: When allopurinol and mercaptopurine are administered concomitantly, the dose of mercaptopurine must be reduced to one third to one quarter of the usual dose to avoid severe toxicity. 

Dosage in TPMT-deficient Patients: Patients with inherited little or no thiopurine-S-methyltransferase (TPMT) activity are at increased risk for severe mercaptopurine toxicity from conventional doses of mercaptopurine and generally require substantial dose reduction. The optimal starting dose for homozygous deficient patients has not been established (see CLINICAL PHARMACOLOGY, WARNINGS and PRECAUTIONS sections). 

Most patients with heterozygous TPMT deficiency tolerated recommended mercaptopurine doses, but some require dose reduction. Genotypic and phenotypic testing of TPMT status are available. (See CLINICAL PHARMACOLOGY, WARNINGS, and PRECAUTIONS sections.) 

Dosage in Renal and Hepatic Impairment: It is probably advisable to start with lower dosages in patients with impaired renal function, due to slower elimination of the drug and metabolites and a greater cumulative effect. Consideration should be given to reducing the dosage in patients with impaired hepatic function.
This group will receive the Fitbit triaxial pedometer that will track their daily steps (self-monitoring component) for the first 3 months. For the second three months of the study, they will receive the Tweet4Wellness intervention in addition to their Fitbit self-monitoring.
The present invention discloses a novel medicine for treating alopecia disease, which takes raw fleece-flower roots, chuanxiong rhizomes, notopterygium roots, gastrodia tubers, prepared rhizomes of rehmannia, mulberry fruits, Chinese angelica, fructus psoraleae, fried date kenels, cacumen biotae, radix et rhizoma rhei, ash barks, black sesame and honey as the raw material. The raw material is prepared with a proportion according to the different characteristics of each traditional Chinese medicine. The present invention is made by the respective treatment of drying, boiling, sterilization, etc. The present invention has a simple formulation and a simple preparation method. The total effective rate is more than 95% for alopecia areata, complete baldness, alopecia universalis and alopecia seborrheica. The present invention also has significant therapeutic effect on refractory alopecia.
Following a study to determine phenylalanine requirements in pregnant women, the investigator's purpose for this study is to determine the phenylalanine and tyrosine requirements (also know as the total aromatic amino acid requirement) in healthy pregnant women as part of a Doctoral Thesis project. The determined requirements can be taken into account when giving dietary recommendations, to ensure healthy pregnancies. The hypothesis is that the current recommendations for phenylalanine and tyrosine intake given to pregnant women are underestimated. The investigators also hypothesize that the phenylalanine and tyrosine requirements at early stages of pregnancy will be lower than the requirements towards the later stages of pregnancy.

Current dietary intake recommendations for the aromatic amino acids are based on factorial (mathematical) calculations and do not account for requirement differences between early and late pregnancy. Static recommendations throughout all stages of pregnancy are not appropriate because of the multitude of adaptations the human body goes through during gestation. Whether phenylalanine and tyrosine requirements differ between different stages of gestation is unknown. The DRI gives a recommendation for total aromatic amino acids of 36 mg/kg/d during pregnancy. The results from this study would allow for a more accurate recommendations in future DRIs.

The investigators will recruit healthy pregnant women aged 20 to 40 in their 13th-19th week of gestation or 33rd to 39th week of gestation. Once they get in contact with the lab, an initial visit (pre-study) will take place. Here, the participants will be measured for their eligibility and taken through the consent form. They have to participate in a pre-study for each stage of pregnancy, if they wish to participate in both stages. If they meet all the criteria and agree to participate, they will return for up to four study days per stage of 8 hours each. Therefore, if they are recruited during late pregnancy they are only able to participate in four study days in total. During these study days they will be fed protein shakes containing the stable isotope, and then oxidation of this isotope will be measured to determine a breakpoint (requirement) of phenylalanine. Breath samples, urine samples, and a small blood sample will be taken during the study day.
It is well documented that there are significant ventilatory changes in respiratory diseases such as cystic fibrosis, asthma and the onset of bronchiolitis obliterans syndrome (BOS) following chronic rejection of lung transplantation. At present, we use measures such as spirometry and lung biopsies to determine the changes of airway function and disease severity. Our aim is to develop a novel technique called the multi breath nitrogen washout (MBNW) which we believe is able to measure the inhomogeneity of ventilation in both the larger airways (conductive region, generation 1 - 16) as well as the smaller airways (acinar region 17 - 23). Our belief is that these measurements are much more subtle than current techniques and will be more sensitive in measuring large and small airway changes in disease. The MBNW can also give us an insight as to which particular zones of the lung are affected in differing respiratory disease. For example, it is believed that BOS begins at the distal portion of the lung (acinar region) and proceeds towards the proximal zone (conductive). However, at present no current techniques can differentiate between damage to the acinar zone and the conductive zone or indeed accurately measure small airway (acinar zone) function. We believe the the MBNW has the capacity to do so.
The specific gamma ray constant for I 123 is 1.6 R/hr-mCi at 1 cm. The first half value thickness of lead (Pb) for I 123 is 0.005 cm. A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from the interposition of various thicknesses of Pb is shown in Table 2. For example, the use of 1.63 cm of lead will decrease the external radiation exposure by a factor of about 1,000.

Note that these estimates of attenuation do not take into consideration the presence of contaminants.

To correct for physical decay of I 123, the fractions that remain at selected intervals after the time of calibration are shown in Table 3.
The Neuroguard IEP® 3-in-1 Direct Carotid Stent and Post-Dilation Balloon System with Integrated Embolic Protection (Neuroguard IEP Direct System) is a combination self-expanding carotid artery stent, nitinol embolic protection filter, and post-dilation balloon. Neuroguard IEP Direct System is used with the Neuroguard Direct Access Kit which includes the Flow Redirection System.
FIELD: medicine. ^ SUBSTANCE: disclosed method refers to medicine, namely to ophthalmology. Long-continued delivery of active retinoid to posterior pole of mammal's eye enables treatment or prevention of proliferative vitreoretinopathy, age-related macular degeneration, and pigmentary retinopathy. It involves subconjunctival or periocular delivery of prodrug retinoid in effective amount actually being ether derivative of active drug 10 times more active than prodrug. ^ EFFECT: method allows for reduced risk of potential complications with decreased concentration of introduced drug. ^ 13 cl, 10 dwg, 2 tbl, 8 ex
Impaired motor and/or cognitive performance attributable to the accumulation of benzodiazepines and their active metabolites following several days of repeated use at their recommended doses is a concern in certain vulnerable patients (e.g., those especially sensitive to the effects of benzodiazepines or those with a reduced capacity to metabolize and eliminate them) [see DOSAGE AND ADMINISTRATION].

Elderly or debilitated patients and those with impaired renal or hepatic function should be cautioned about these risks and advised to monitor themselves for signs of excessive sedation or impaired conditions.

Estazolam appears to cause dose-related respiratory depression that is ordinarily not clinically relevant at recommended doses in patients with normal respiratory function. However, patients with compromised respiratory function may be at risk and should be monitored appropriately. As a class, benzodiazepines have the capacity to depress respiratory drive; there are insufficient data available, however, to characterize their relative potency in depressing respiratory drive at clinically recommended doses.

As with other benzodiazepines, estazolam should be administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional overdosage is more common in this group of patients; therefore, the least amount of drug that is feasible should be prescribed for the patient at any one time.
Total hip arthroplasties (THAs) are used to restore locomotion. More than 150,000 THAs are performed each year in France. Better outcomes require a restoration of limb lengths and anatomy. Post-operative discrepancy is the main cause of complaints and financial compensation in the US after THA. As such, the investigators aim to use preoperative digital planning using TraumaCad to optimize the restoration of the center of rotation of the hips. Preoperative planning are usually performed using anteroposterior standard radiographs, which are scaled to an inaccurate scale. The TraumaCad system (Brainlab®) allows the adjustment of the scales to each patient and the virtual positioning of the implants in order to simulate the intervention for the restitution of the geometrical parameters of the hip.
The first dose of everolimus was to be administered not later than 24 hours after transplantation with a starting dose of 1.5 mg bis in diem/twice a day (b.i.d.) thereafter adjusted to maintain the trough blood levels between 3 and 8 ng/ml. Tacrolimus was to be initiated within 24 hours after reperfusion of the graft with a starting dose of 0.1 mg/kg/day thereafter adjusted to maintain the trough blood levels between 4 and 7 ng/ml. Up to months three all patients received the same treatment and after three months patients in this arm received tacrolimus to reach a trough blood level between 1.5 and 3 ng/ml. All patients received two doses of 20 mg basiliximab, administered as an intravenous bolus injection. The first dose was given on the day of transplantation, with the second dose being administered on the fourth day post-transplant. Intravenous (i.v.) prednisone (or equivalent) was given pre- or intra-operatively according to center practice.
BACKGROUND: Dermatofibrosarcoma Protuberans (DFSP) is a rare, low-grade malignant tumor of the dermis with a high recurrence rate post-surgery. Current treatments, including surgery, radiotherapy, and targeted therapy, have limitations. Photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) is a promising non-invasive approach, but its efficacy in DFSP treatment remains underexplored.
METHODS: This study aimed to evaluate the anti-tumor efficacy of 5-ALA PDT using an in vitro model derived from a recurrent DFSP patient. The cells were treated with varying concentrations of 5-ALA and exposed to red light, followed by assessments of cell viability, proliferation, apoptosis, migration, invasion, angiogenesis, and expression of DFSP-related genes and proteins.
RESULTS: 5-ALA PDT significantly reduced DFSP cell viability in a dose-dependent manner and induced apoptosis. It also effectively inhibited cell proliferation, migration, and invasion, as well as suppressed angiogenic activity in conditioned media. Furthermore, 5-ALA PDT downregulated the expression of COL1A1 and PDGFRB, key genes in DFSP pathogenesis.
CONCLUSIONS: The findings provide the first evidence of 5-ALA PDT's in vitro anti-tumor efficacy against DFSP, suggesting its potential as a novel therapeutic approach for DFSP. Further studies are warranted to explore the clinical utility of 5-ALA PDT in preventing DFSP recurrence.
The invention relates to skin-care cream. The skin-care cream has effects of resisting bacteria by traditional Chinese medicines and preventing rough skin. The skin-care cream can effectively kill bacteria and improve skin roughness. The skin-care cream is obtained by mixing 8-14 parts by weight of chrysanthemum water, 2-3 parts by weight of glycerin, 1-2 parts by weight of snake oil essence, 5-8 parts by weight of folium artemisiae argyi, 2-3 parts by weight of lemon, 5-8 parts by weight of Vaseline, 2-4 parts by weight of phenoxyethanol, 3-5 parts by weight of urea acid, 1-3 parts by weight of polydimethylsiloxane, 1-2 parts by weight of essence, 1-3 parts by weight of vinegar and 1-2 parts by weight of glycerol. The skin-care cream can be used for hands influenced by work and an environment, has effects of effectively killing bacteria, preventing rough skin, effectively nourishing skin and improving skin, and does not damage the skin. Hyaluronic acid used by the skin-care cream is used for storing moisture, improving a skin volume and making skin plump, sonsy and elastic.
A method, a computer-readable medium and a system for assessment of a hemodynamic response to an Adenosine receptor agonist stimulation for a human patient are disclosed. Starting point for the method are non-invasive pressure data in the resting state. Said data are used in pharmacokinetic/pharmacodynamic modeling to arrive at an individual patient-specific response for an adenosine receptor stimulation by an agonist. This response is used to a calibrate lumped-parameter Windkessel type model of a blood circulation. The calibrated model allows for calculating of hemodynamic parameters for the hyperemic state, in particular to calculate flow and pressure values in both coronary arteries inlets. The hemodynamic parameters allow for in silico coronary vessel diagnostic. The effectiveness of the developed method has been confirmed in multi-center clinical trials.
Participants receive a gain framed notification that they are eligible for a flu shot. In addition, participants are told "Many people find it helpful to make a plan to get their shot" and are asked to commit by texting back "I will get a flu shot." Depending on their response, participants receive a general reminder or a commitment reminder 3 days later.
In sports are "Cooling Ice Spray" applications after an injuries one of the most common and popular methods used. It is very popular mainly because of its analgesic effect and easy application. It is assumed that such application will not affect the athletes. Nevertheless after an application of cold a reduced nerve conduction velocity was measured, resulting in a reduction in pain and a reduced transmission rate. Usually the static equilibrium or the perception of joint position was investigated and not the time to stability. As far as we have been known so far been no study that has examined the impact of a brief application of cooling ice spray on the time to stability after dynamic function. Therefore this study what's to investigate the influence of "Cooling Ice Spray" on the time to stability after a forward jump.