anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To investigate the effectiveness of real-time tracking and virtual reality technology(RTVI) used to assist the intraoperative alignment of the trauma orthopaedic surgery robot for the treatment of femoral neck fractures and its impact on the treatment outcome.
METHODS: A retrospective analysis was conducted on 60 patients with femoral neck fractures treated with trauma orthopedic robotic surgery from September 2020 to September 2022. Patients were divided into two groups according to whether RTVI technology was used during surgery to assist robotic surgery. There were 28 patients in the RTVI group (12 males and 16 females), with an average age of (46.2±9.3) years old ranging from 28 to 60 years old. There were 32 patients in the simple Tianji surgical robot group, including 15 males and 17 females, aged (48.2±7.8) years old ranging from 32 to 58. The number of registered fluoroscopy, operation time, total number of intraoperative fluoroscopy, intraoperative blood loss, and hospitalization time of the two groups of patients were observed and recorded. All patients received regular follow-up after surgery, and hip X-rays were routinely reviewed to record Garden alignment index, fracture healing time, postoperative complications, and Harris score.
RESULTS: All 60 patients were followed up. The RTVI group was followed up for 9 to 16 months with an average of (13.0±1.2) months, and the Tianji surgical robot group alone was followed up for 10 to 14 months with an average of (12.0±1.3) months. During the follow-up period, the femoral neck fractures of both groups of patients healed well, and no complications such as internal fixation loosening and incision infection occurred. The number of registered fluoroscopy, operation time, and number of intraoperative fluoroscopy of patients in the RTVI group were significantly better than those in the simple Tianji surgical robot group(P<0.01). There was no statistically significant difference in intraoperative blood loss, hospital stay, Garden alignment index, fracture healing time, and hip Harris score between two groups(P>0.05).
CONCLUSION: Although RTVI technology assisted by the surgical robot for femoral neck fracture surgery has little impact on its postoperative outcome, it can effectively reduce the operating time, the number of intraoperative X-ray projections, and the risk of intraoperative radiation exposure to patients. It also shortened the learning curve of the operator and better reflected the precision and efficiency of the trauma orthopaedic surgery robot.
Breast cancer (BC) is the second-most common cancer in women in sub-Saharan Africa (SSA) (Black 2019, Trimble 2017). Tamoxifen forms a cornerstone for treatment of ER+ breast cancer and daily use after initial medical, surgical, and/or radiation therapy decreases the annual odds of recurrence and death by 39% and 31% respectively (EBCTCG 2005). Despite the proven benefits of tamoxifen, non-adherence is common. Previous reports have indicated that 31-50% of women do not adhere to prescribed treatment regimens (Lash 2006, Lambert 2018, Peddie 2021). The reasons for non-adherence are broad and not fully understood but are thought to be influenced by numerous factors including medication side-effects, beliefs about cancer, and social support framework (Clancy 2020). Data is extremely limited concerning the adherence rates to tamoxifen therapy in Africa.

The metabolism of tamoxifen is complex. It is metabolized to its effector/active metabolites via the cytochrome P450 (CYP) enzyme system, principally CYP2D6 with CYP2B6 playing a lesser, but important role (Nthontho Keneuoe Cecilia 2022). The CYP2D6 gene is highly variable but four principal drug metabolizer phenotypes have been identified: poor, intermediate, extensive, and ultra-rapid metabolizers (Nthontho KC 2022). Reduced speed of tamoxifen metabolism in poor metabolizers has been associated with higher risk of treatment failure, due to increased drug level in vivo and subsequent increased tamoxifen related side effects (Nardin 2020). However, to date, these various phenotypes have not been evaluated in an African population, so it is unclear to what extent these phenotypes effect tamoxifen adherence in SSA.

A unique aspect among the breast cancer population in Botswana is that a large portion of these women are also living with HIV. Studies have shown that the prevalence of HIV in the general population is up to 17.6% (Bhatia 2019). Little is known how antiretroviral medications effect tamoxifen adherence. One particular Anti Retroviral Therapy (ART) medication, efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor and potent CYP-inducer is used by a large portion of WLW HIV in SSA (Maseng 2022). EFV has been shown in vitro to increase estrogen expression both by inducing growth in ER-positive breast cancer cells lines (Sikora 2010) and clinically due to the development of gynecomastia seen in male patients (Osman 2020). It remains unclear, however, if and to what extent the combined administration of tamoxifen and efavirenz contributes to reduced tamoxifen adherence.
In the sham group, the stimulation parameters, including the stimulation site and duration, were identical to those of the anodal group. However, during the 10-second ramp-up and ramp-down periods before and after stimulation, patients were unaware that the current was turned off.
Understanding the mechanisms behind the interaction of empathy for pain (EfP) and working memory (WM), particularly how they are influenced by social factors like perceived social distance (SD), is vital for comprehending how humans dynamically adapt to the complexities of social life. However, there is very little known about these mechanisms. Accordingly, we recruited 116 healthy participants to investigate the bidirectional influence and electrophysiological responses between WM and EfP, including the role of SD. Our research results revealed that the interaction between WM load and SD significantly influenced the processing of EfP. Specifically, high WM load and distant SD facilitated early processing of EfP. Conversely, low WM load and close SD promoted late processing of EfP. Furthermore, the interaction between EfP and SD significantly influenced the performance of ongoing WM tasks. Specifically, the kin's pain, compared to kin's nonpain, improved the participant's performance on low-load WM tasks; however, it diminished the participant's performance on tasks with high WM load. Overall, these results provide evidence at both behavioral and neural levels for the mutual influence of WM and EfP during the same temporal process, and SD emerged as a crucial moderating factor during these mutual influences.
PURPOSE: To obtain a new pyridine derivative presenting the survival extension for cultured corticocerebral neurocytes, thus useful for remedying of treating neuropathy either directly or indirectly involved in neurocyte activity or neurodegeneration in vivo. CONSTITUTION: This new pyridine derivative (salt) is expressed by formula I (R<1> is a functional group of formula II, III, etc.), e.g. N-[2-(dimethylamion) ethyl]-4-(2,6-diphenyl-4-pyridyl)benzamide. The compound of formula I is obtained, for example, by condensation reaction between a compound of formula IV (R<3> is methyl, carboxyl, etc.) and a compound of formula V (R<4> is H, carboxyl, etc.) in the presence of an alkali followed by reaction of the resultant product with a compound of formula VI in the presence of ammonium acetate. This pyridine derivative can be administered either orally or parenterally, its appropriate dose being 1-1000mg/adult a day.
With ethical committee's approval the investigarors recruited for this cross-over trial pediatric anesthesiologists and intensivists. Emergency tracheotomy consists of four steps: vertical skin incision, strap muscles separation (2 Backhaus clamps), anterior luxation of the trachea with a 3rd clamp, and vertical puncture with tip-scissors of no more than 2 tracheal rings to insert the tube. The scalpel-bougie-tracheostomy involves separation of neck tissues to expose the trachea and tracheal incision both with a scalpel to insert the bougie to facilitate tracheal intubation. Participants were randomized to start either with emergency tracheotomy or scalpel-bougie-tracheostomy. They watched an instructional video and had four practicing attempts, followed by a fifth attempt which was assessed. Afterward, they crossed over to the other technique.
Aspecific needle skin stimulation. Administration of 12 sessions (2 per week for 6 weeks). Each session lasts 20-30 minutes.
All participants will receive one injection per week during a 12-week dose escalation period. From week 13 to week 40, the 1.0 mg group will receive an additional injection of semaglutide placebo in order to maintain the blinding.
Individuals with disabling conditions, such as stroke, multiple sclerosis, or rheumatoid arthritis, face many barriers to engaging in physical activity, healthy nutritional habits, and good sleep hygiene. This leads to weight gain, de-conditioning, and declines in upper- and lower- extremity function, which makes it even more difficult to engage in healthy behaviors, thereby perpetuating a cycle of functional decline. Developing an effective weight management intervention may be a strategy for disrupting this disabling cycle and reducing the impact of the disease. Fostering a positive social environment may help adults with disabling conditions overcome barriers to engaging in healthy behaviors. SystemCHANGE (SC) is a new behavior change program that uses approaches consistent with social ecological theories and process improvement techniques (i.e. changing the dynamics of a system or group) to increase social support in lifestyle behaviors that promote energy balance. SC focuses on redesigning the social environment using a series of trial-and-error "experiments", which is in contrast to cognitive-behavioral interventions that focus on changing a person's viewpoint of a situation and increasing motivation. In a SC intervention, individuals are taught a set of skills to assist them in incorporating habitual lifestyle behaviors into their daily systems so they succeed despite wavering motivation. The rationale for developing a weight management intervention for these patients is to slow disability progression and prevent secondary conditions.
PURPOSE:To obtain an additive useful in a desired state such as gel-like or powdery state and especially useful as a thickening agent for coating by treating a clay mineral with a specific cationic surfactant to make interior of layer lipophilic and then adding a lipophilic substance thereto. CONSTITUTION:A 10-200 milliequivalent cationic surfactant being a primary, secondary or tertiary amine salt or a quaternary ammonium salt, having two or more >=10C alkyl groups and containing at least one or more kinds of ester bond, ether bond and amine bond [e.g. N-(3-alkoxy-2-hydroxypropyl) trialkylammonium halide] is added to 100g clay mineral (e.g. montmorillonite) and water is further added thereto, and the mixture is sufficiently stirred or kneaded. The blend is washed with water, dehydrated and then washed with a mixed liquid of water and a hydrophilic organic solvent (e.g. methanol) and powdered by vacuum drying, etc. A liquid lipophilic substance (e.g. liquid paraffin) is added thereto and mixed with the powder to provide the objective composition.
The invention discloses a medicine for treating rheumatism and skin diseases by combining traditional Chinese medicine carbonization with paraffin, a preparation method and uses. The medicine for treating rheumatism and skin diseases by combining traditional Chinese medicine carbonization with paraffin comprises the following components: peach kernel, safflower, Angelica sinensis (Oliv.) Diels, unprocessed rehmannia root, radix achyranthis bidentatae, Ligusticum chuanxiong Hort., Platycodon grandiflorus (Jacq.) A. DC., radix sileris, Radix et Rhizoma Asari, common bletilla tuber, folium artemisiae argyi, Leonurus artemisia, Coptis chinensis Franch., cortex phellodendri,Scutellaria baicalensis Georgi, Mentha haplocalyx Briq., borneol, Selaginella tamariscina (P. Beauv.) Spring, moutan bark, pine needle, Taxus chinensis, Hedyotis diffusa Willd, dandelion and bunge corydalis herb. The medicine disclosed by the invention is used for treating the rheumatism and the skin diseases.
Teratogenic Effects: Pyrimethamine has been shown to be teratogenic in rats when given in oral doses 2.5 times the human dose for treatment of toxoplasmosis. At these doses in rats, there was a significant increase in abnormalities such as cleft palate, brachygnathia, oligodactyly, and microphthalmia. Pyrimethamine has also been shown to produce terata such as meningocele in hamsters and cleft palate in miniature pigs when given in oral doses 5 times the human dose for the treatment of toxoplasmosis.

There are no adequate and well-controlled studies in pregnant women. Pyrimethamine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Concurrent administration of folinic acid is strongly recommended when used during pregnancy.
The invention discloses a robot interaction and control system for a logistics robot in a hospital, and belongs to the field of logistics robots. The system comprises a task issuing APP module, a vehicle-mounted APP module and a driving control system module, wherein the task issuing APP module, the vehicle-mounted APP module and the driving control system module are in communication connection with a server, and the server is connected with a vehicle-mounted industrial personal computer of logistics. The invention simulates the design of a driving control system, which is the most key characteristic of the invention, designs a driving system of the automobile by simulating the driving cabin of the automobile, and can easily and flexibly carry out manual intervention when the trolley is in danger and inconvenient to decide by an algorithm of the trolley. The whole logistics robot system is organically integrated. The whole system can sense that the effect of other modules on the whole system is innovated, and a simulated manual driving system is adopted. The remote manual intervention becomes a reality. And becomes more flexible.
The numerical expressions were presented in a positive way: e.g. treatment was successful for 4 out of 10 persons.
There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Acetaminophen and Codeine Phosphate Tablets, USP immediately and seek medical care if they experience these symptoms. Do not prescribe Acetaminophen and Codeine Phosphate Tablets, USP for patients with acetaminophen allergy. 

In the presence of head injury or other intracranial lesions, the respiratory depressant effects of codeine and other narcotics may be markedly enhanced, as well as their capacity for elevating cerebrospinal fluid pressure. Narcotics also produce other CNS depressant effects such as drowsiness, that may further obscure the clinical course of the patients with head injuries.

Codeine or other narcotics may obscure signs on which to judge the diagnosis or clinical course of patients with acute abdominal conditions.

Codeine is habit-forming and potentially abusable. Consequently, the extended use of this product is not recommended.

Acetaminophen and codeine phosphate tablets contain sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
Patients receive TAS-102 PO BID Monday-Friday on weeks 1, 3, and 5. Patients also undergo IMRT or 3D-CRT 5 days per week on weeks 1-5. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients then undergo standard of care FOLFOX or CAPOX.
The measurement will begin after the patient's arrival at the operating theatre, after the control of the documentation and beginning of the vital signs monitoring. The measurement will be terminated at the occurence of the first ETCO2 wave, after securing the airway with laryngeal mask or orotracheal intubation. For the inhalation induction sevoflurane will be used (in the mixture with O2 + air, or O2 + N2O).
Development of thrombosis is closely associated with poor prognosis in cancer patients. Cancer patients often fulfill Virchow's triad of hyper-coagulable state, vascular endothelial injury, and venous stasis. Cancer cells aberrantly express a variety of procoagulant factors, including tissue factor and podoplanin. Chemotherapeutic agents and radiation cause vascular endothelial injury, and reduced daily activity and bed rest for chemotherapy lead to venous stasis. Due to these factors, cancer patients are at high risk of developing thrombosis. Cancer patients are also at high risk of bleeding when they have disseminated intravascular coagulation and/or chemotherapy-induced thrombocytopenia as complications. International societies, such as the American Society of Clinical Oncology and the International Initiative on Thrombosis and Cancer (ITAC), have published clinical guidelines to help physicians better manage cancer-associated thrombosis (CAT). These guidelines recommend use of low molecular weight heparin or direct oral anticoagulants for the prevention of CAT, but unfortunately use of these drugs is not approved in Japan. This gap between Japan and other countries needs to be closed.
<P>PROBLEM TO BE SOLVED: To provide an anti-HIV agent having activities for inhibiting HIV integrase.  <P>SOLUTION: The anti-HIV agent contains a β-ketoamide compound represented by general formula [1] (e.g. tert-butyl 4-[N-phenyl-N-(3-phenylpropyl)]amino-2,4-dioxobutanoate), a pharmaceutically acceptable salt thereof and a compound thereof. The β-ketoamide compound of general formula [I] has activities of inhibiting the HIV integrase activities, and useful as a treating or preventing agent of AIDS as the anti-HIV agent. The β-ketoamide can be formed into a more effective anti-HIV agent by using the ketoamide compound in combination with other anti-HIV agents such as a protease inhibitor and a reverse transcriptase inhibitor. The ketoamide compound can be a medicine safe to a human body and having little side effects because the ketoamide compound has high inhibiting activities specific to the integrase.  <P>COPYRIGHT: (C)2004,JPO
Proximity-induced pharmacology (PIP) for amyloid-related diseases is a cutting-edge approach to treating conditions such as Alzheimer's disease and other forms of dementia. By bringing small molecules close to amyloid-related proteins, these molecules can induce a plethora of effects that can break down pathogenic proteins and reduce the buildup of plaques. One of the most promising aspects of this drug discovery modality is that it can be used to target specific types of amyloid proteins, such as the beta-amyloid protein that is commonly associated with Alzheimer's disease. This level of specificity could allow for more targeted and effective treatments. With ongoing research and development, it is hoped that these treatments can be refined and optimized to provide even greater benefits to patients. As our understanding of the underlying mechanisms of these diseases continues to grow, proximity-induced pharmacology treatments may become an increasingly important tool in the fight against dementia and other related conditions.
Thrombopoietin Receptor Agonists (TPO-RAs) are novel treatments for patients with chronic Primary Immune Thrombocytopenia (ITP). According to the findings of mechanism-based studies, rhTPO competes with endogenous TPO for binding to TPO-R while avatrombopag has an additive effect with endogenous TPO, indicating that the treatment mechanism and side-effect profiles could be somewhat different between these drugs. If there is cross-resistance between 2 drugs for the treatment of adult ITP is still no answer. The purpose of this study is to investigate the efficacy and safety of switching avatrombopag and rh-TPO in adults with ITP.This is a non-interventional study. Patients who fail previous steroids and receive rh-TPO and then switch to avatrombopag or vice versa will be enrolled. The reason for switch will be recorded. The efficacy, safety, and patient/physician preference will be assessed and compared between the two agents.
PURPOSE OF REVIEW: Vascular and valvular calcification are associated with cardiovascular morbidity and mortality in people with chronic kidney disease (CKD). Uncertainty exists regarding therapeutic strategies to attenuate calcification. This review outlines the pathophysiological mechanisms contributing to vascular and valvular calcification, considers the mechanisms of action of therapeutic interventions, and reports the latest outcomes from interventional studies.
RECENT FINDINGS: Conventional therapies targeted at CKD-mineral and bone disorder (MBD) modulation have yielded conflicting or inconclusive results. Magnesium and vitamin K supplementation appear to offer attenuation of coronary artery calcification but inconsistent findings justify the need for further studies. Strategies targeting hydroxyapatite formation such as sodium thiosulphate and hexasodium fytate show promise and are worthy of further evaluation. The serum calcification propensity assay (T50) correlates with severity and progression; it holds promise as a potential future clinical tool for screening monitoring calcification risk.
SUMMARY: Whilst knowledge of the pathophysiology of vascular calcification has grown and therapeutic approaches appear promising, as yet no medication has been approved to treat vascular or valvular calcification, or calciphylaxis.