anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Ulcerative colitis (UC) is a chronic inflammatory bowel disease usually treated by azathioprine. It is a well-established risk factor for colorectal cancers and extraintestinal malignancies. Nevertheless, the risk of myeloid leukemia in patients with UC is less known. We report a case of a 51-year-old patient, with a history of extensive ulcerative colitis, who was treated with azathioprine at a dose of 2.5 mg/kg/day. Seven years later, he presented an increased count of white blood cells at 25,400/μL and of platelets at 1,382,000/μL. Peripheral blood smear showed 1% blasts and 20% myelemia. The karyotype showed the Philadelphia chromosome and the RT-PCR revealed the BCR-ABL transcript. Thus, chronic myeloid leukemia (CML) was confirmed and imatinib was prescribed. This case reported a rare and serious event in a UC patient and illustrates the importance of closely monitoring this population.
Healthy control subjects will be recruited from the hospital staff and students at the University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany. They have to be free from any neurological or psychiatric disorder, according to DSM-IV and ICD-10 criteria.
PURPOSE:To obtain an ultraviolet ray absorber, consisting of an extract of licorice with an organic solvent and having remarkable absorption within a long wavelength ultraviolet ray region with high safety. CONSTITUTION:An ultraviolet ray absorber, consisting of an extract of a leguminous plant Glycyrrhiza glabra var. glandulifera Reder et Herder, preferably Glycyrrhiza echinata L. produced in Hsinchiang in China or Glycyrrhiza inflata Batal. with an organic solvent and having remarkable absorption within a longwavelength region of 320-400nm wavelength (i.e., having absorption maximum). A lower aliphatic alcohol, lower aliphatic ketone, lower aliphatic ether, volatile hydrocarbon, etc., are used as the organic solvent for extraction. The raw material to be treated is dipped in the solvent in an amount of 3-5times and heated while being refluxed or dipped therein in an amount of 5-10times at ordinary temperature to carry out the extraction.
INTRODUCTION: Vasomotor symptoms (VMS) associated with menopause can negatively affect health-related quality of life (HRQoL). The Menopause-Specific Quality of Life (MENQOL) questionnaire has been developed to assess QOL specific to menopause. The objective of the current study was to assess the psychometric properties, sensitivity to change, and clinically meaningful within-patient change of the MENQOL using data from the fezolinetant SKYLIGHT 1 and 2 studies in individuals with VMS.
METHODS: Individuals aged ≥ 40 to ≤ 65 years with moderate-to-severe VMS (≥ seven hot flashes/day) were enrolled. In addition to MENQOL, eight patient-reported outcome (PRO) measures were used for the psychometric evaluation. All PRO assessments were completed at weeks 4 and 12 during the treatment period, and most were completed at baseline. Psychometric analyses included factor analysis and reliability, construct validity, and sensitivity to change assessments. The within-patient threshold for a clinically meaningful change in MENQOL was derived.
RESULTS: In total, 1022 individuals were included from SKYLIGHT 1 and 2. Mean MENQOL total score at baseline was 4.30, improving to 3.16 at week 12. The confirmatory factor analysis supported established MENQOL domain structure, including the overall score. The internal consistency of the MENQOL overall and domain scores was supported using Cronbach's alpha and McDonald's omega, and MENQOL construct validity was supported for overall and domain scores. Item-to-item and item-total correlations were generally sufficient, and moderate test-retest reliability was noted. The scales against which construct validity and responsiveness for MENQOL domains were examined were moderately related to the MENQOL domains in general, providing additional support for acceptable measurement properties of MENQOL in this population. A reduction in MENQOL overall score of ≥ 0.9 points was identified as responding to treatment (a clinically important threshold). Thresholds of 2.0 points for the vasomotor domain and 0.9 for the psychosocial domain were estimated, in addition to distribution-based threshold estimates of 0.8 and 1.2 for the physical and sexual domains, respectively.
CONCLUSIONS: The psychometric properties of the MENQOL overall and domain scores support use of this instrument to capture experiences among individuals with moderate-to-severe VMS associated with menopause and assess related endpoints in clinical trials.
TRIAL REGISTRATION: ClinicalTrials.gov identifiers NCT04003155 and NCT04003142.
Group A: Control Group: The only form of physical therapy (CPT) given to this group will be conventional CPT. These regular workouts will include dynamic and static stretching, walking-specific functional exercises, passive mobilizations for pain-free mobility, balance modulation, and gait training. At baseline, the functional state of both groups will be evaluated. Treatment sessions will run for a total of 12 weeks, five days a week, for 45 minutes each. They will consist of four to six repeated exercises, six times on average, and use BSID-4 once the trial is over.

Group B: Experimental Group: In addition to regular physical therapy, this group will also get Cuevas Medak exercises, such as head and trunk control (by stabilizing limb) and standing to sitting transition. For a duration of 12 weeks, five days a week, and 45 minutes, each session will be held. At baseline, the functional state of both groups will be evaluated. then once the sessions are over, more data will be gathered using BSID-4.
Rome IV recommended esophageal biopsies in patients with dysphagia and normal endoscopy to exclude mucosal disease. Thus far, studies evaluating the utility of this recommendation remain scarce. The aims of this study were to determine the value of random esophageal biopsies in heartburn patients with dysphagia and normal endoscopy and compare the yield of random esophageal biopsies between younger versus older patients. Data were collected from consecutive patients presenting with dysphagia, 18 years and older, who were on proton pump inhibitors and had normal upper endoscopy. Biopsy results of patients with and without heartburn were recorded. Logistic regression analysis was used to compare normal versus abnormal biopsy results in younger and older patients accounting for confounding variables. The number of abnormal biopsies was significantly higher than normal biopsies (68% and 32%, respectively, P = 0.0001). Among abnormal biopsy results, microscopic gastroesophageal reflux disease was significantly more common than all other findings (39%, P = 0.0495). There was no significant difference in biopsy results in patients with and without heartburn as well as younger versus older patients (P = 0.3384, P = 0.1010, and P = 0.8468, respectively). Our study demonstrated that most patients with dysphagia and normal upper endoscopy who are on proton pump inhibitor have some type of histologic mucosal abnormality, which can direct future management. Among abnormal biopsies, microscopic reflux was by far the most common finding in patients with or without a history of heartburn. While this supports the management strategy proposed by Rome IV, age did not drive esophageal biopsy results.
Intermediate Risk (IR) NMIBC group of participants studied include ones with AUA/SUO criteria such as : recurrence within 1 year low grade Ta, solitary low grade Ta \>3 cm, multifocal low grade Ta, high grade Ta ≤3 cm, low grade T1 Note: Ta means the cancer is just in the innermost layer of the bladder lining. T1 means the cancer has started to grow into the connective tissue beneath the bladder lining.
The invention relates to the identification of the molecular basis of Williams syndrome. More specifically, the invention has identified that elastin causes or is involved in the pathogenesis of Williams syndrome. Molecular variants of the elastin gene contribute to Williams syndrome. The analysis of the elastin gene will provide an early diagnosis of subjects with Williams syndrome. The diagnostic method comprises analysing the DNA sequence of the elastin gene of an individual to be tested and comparing it with the DNA sequence of the native, non-variant elastin gene. In a second embodiment, the elastin gene of an individual to be tested is screened for mutations associated with Williams syndrome. Presymptomatic diagnosis of Williams syndrome will enable practitioners to prevent vascular obstruction using existing medical therapies like beta adrenergic blocking agents.
This invention concerns phenolic extracts containing procyanidins, propelargonidins and prodelfinidins obtained from peel of the almond [Prunus dulcís (Mili.) D.A. Webb, Prunus amygdalus (L.) Batsch., Amygdalus dulcís (Mili.), Amygdalus communis (L.) or Prunus communis (L.)]. In particular, the objective is to obtain extracts rich in proanthocyanidins with type-A bonds. The preparation method for which protection is also claimed consists in: a) a maceration of plant material with organic solvents at 25-100 DEG C, b) purification by liquid-liquid extraction and/or adsorption or ion exchange chromatography, and c) optionally, a final drying. Also protected are the possible activities/properties of these extracts such as anti-oxidant activity and others, which determine the use thereof as a nutritional or health ingredient, and the use thereof in the cosmetic and pharmaceutical industry.
For judo athletes with visual impairments and their coaches, understanding possible muscle adaptations can be challenging. As it is commonplace for these adaptations to include interlimb asymmetry, we analyzed the magnitude and direction of interlimb asymmetry in judo athletes with visual impairments and verified the association of this asymmetry with their unilateral physical performances. Participants were 18 elite judo athletes (10 male, 8 female) with visual impairments. These athletes performed three physical tests: countermovement jump (CMJ), medicine ball throw (MBT), and handgrip strength (HGS), while we conducted unilateral right and left side assessments using the interlimb asymmetry equation for each physical test. Our main results showed that the CMJ and MBT tests presented asymmetry values above 10%; with CMJ significantly higher than HGS (p = 0.050), and with inconsistencies across the three tests in the direction of interlimb asymmetry (k = -0.22-0.26). Unilateral CMJ (left limb) was negatively correlated with asymmetry (r = -0.51; p = 0.031), and unilateral MBT (right limb) was positively correlated with asymmetry (r = 0.52; p = 0.024). Based on these results, coaches should prioritize regular assessments of interlimb asymmetry using these specific tests. This data can guide the construction of training programs aimed at minimizing asymmetry and enhancing overall physical performance. Continuous monitoring and adjustment of training strategies based on asymmetry findings are crucial for optimizing muscle balance in judo athletes with visual impairments.
PCT No. PCT/JP94/01804 Sec. 371 Date Apr. 23, 1996 Sec. 102(e) Date Apr. 23, 1996 PCT Filed Oct. 27, 1994 PCT Pub. No. WO95/11698 PCT Pub. Date May 4, 1995A method for stabilizing protein C or activated protein C and a preparation obtained by said method are provided, said method and preparation being applicable during procedures such as isolation and purification, lyophilization, heating, etc. or when stored. To a salt buffer containing protein C or activated protein C and sodium ion are added at least one amino acids, and further either one or a combination of albumin and a non-ionic surfactant.
Accordingly, embodiments herein disclose a compound and method of small molecule inhibitors or ligands for diagnosis and treatment of cancers such as prostate, brain, breast, etc., and neurodegenerative diseases. A new class of PSMA inhibitors called as aminoacetamide, 1, has been designed by extensive in silico studies. A simple, mild and high yielding synthetic methodology is developed for 1 and shown to have high affinity for PSMA protein. Fluorescent conjugates 22 and 25 derived from 1 show selective uptake in prostate cancer cell lines and can be used for surgical removal of tumors during intra-operative surgery. Conjugates 31 and 34 for tagging 99mTc radioisotope were synthesized. Macrocyclic chelating cores such as DOTA, NOTA or prosthetic groups can be introduced to tag radionuclides 68Ga, 64Cu, 18F and 177Lu for diagnosis and treatment of PCa, incurable mCRPC and neurodegenerative diseases such as ALS, schizophrenia and neuropathic pain that over-express PSMA protein.
There is disclosed herein dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.
The invention relates to the field of biology and aims to provide application of high mobility group box (HMGB) protein and antibody to the preparation of an ostrea rivularis anti-infection immune preparation. The amino acid sequence of the protein is shown as the SEQ ID NO:2; the coding frame nucleotide sequence of the gene is shown as the SEQ ID NO:1; the application of the protein to the preparation of the ostrea rivularis anti-infection immune preparation is to immunize New Zealand white rabbits by using the protein so as to obtain polyclonal antiserum. According to the invention, the ostrea rivularis HMGB gene coding frame full sequence is obtained; the soluble HMGB protein product is expressed and purified by establishing a prokaryotic expression vector; and the polyclonal rabbit antiserum is prepared. The polyclonal rabbit antiserum has the effect of inhibiting inflammatory response caused by ostrea rivularis pathogeny RLO and gram negative bacteria LPS as well as necrobiosis and apoptosis.The invention relates to the field of biology and aims to provide application of high mobility group box (HMGB) protein and antibody to the preparation of an ostrea rivularis anti-infection immune preparation. The amino acid sequence of the protein is shown as the SEQ ID NO:2; the coding frame nucleotide sequence of the gene is shown as the SEQ ID NO:1; the application of the protein to the preparation of the ostrea rivularis anti-infection immune preparation is to immunize New Zealand white rabbits by using the protein so as to obtain polyclonal antiserum. According to the invention, the ostrea rivularis HMGB gene coding frame full sequence is obtained; the soluble HMGB protein product is expressed and purified by establishing a prokaryotic expression vector; and the polyclonal rabbit antiserum is prepared. The polyclonal rabbit antiserum has the effect of inhibiting inflammatory response caused by ostrea rivularis pathogeny RLO and gram negative bacteria LPS as well as necrobiosis and apoptosis.
An agent for the permanent shaping of human hair contains at least one thio cpd. reducing agent, (esp. thioglycolic acid and/or its salt). The agent comprises two compsns. (A) and (B) which are kept separately until use, when they are mixed together to form a compsn. with a pH of 7 - 8 that is applied to the hair. (A) is an aq. soln. with a pH of 3.0 - 6.5, contg. cysteine or its hydrochloride, 1 - 100 ppm of at least one iron (II) salt and opt. a polyol or its methyl or ethyl ether. (B) has a pH of ca. 8 - 12, and contains at least one alkaline agent chosen from ammonium  carbonate, hydrogen carbonate or carbamate.
Reproduction requires high amounts of energy, and challenging environments during breeding can force parents to prioritize their current reproductive bout over self-maintenance or vice versa. However, little is known about how common stressors, such as food restriction, can influence these trade-offs during breeding, and the physiological mechanisms for these trade-off decisions. In this study, adult zebra finches (Taeniopygia castanotis) were subjected to a control diet (ad libitum) or a 40% food restriction while raising nestlings and fledglings, and we measured body mass, furculum fat, plasma corticosterone (CORT) and blood glucose levels of the parents at the time of pairing, when their offspring fledged, and when their offspring reached nutritional independence. We also measured body mass and growth rate in the offspring from hatching until the end of the treatment period. Food-restricted parents had lower body mass when their offspring fledged and reached nutritional independence and higher baseline CORT when their offspring fledged compared to controls. Offspring did not differ in body mass or growth rate between treatment groups. However, there was no effect of food restriction on parents' furculum fat, baseline glucose, the adrenocortical response, or the glucose response. Furthermore, path analysis results suggest that alterations in baseline glucose is the primary driver of changes in body mass in parents and offspring brood mass. Taken together, these results suggest that food restriction during chick rearing in a short-lived passerine drives parents to prioritize their current reproductive bout over self-maintenance, and glucose could potentially be a mechanism for diverting energy toward parental effort.
BACKGROUND: Telomere shortening and RNA pseudo-uridylation are common features of tumors. NOP10 is a member of the H/ACA snoRNP family, essential for maintaining telomerase activity and RNA pseudouridylation. NOP10 has been indicated to be substantially expressed in tumors such as breast and lung cancers and is associated with poor prognosis. Currently, no investigation exists on NOP10 in pancreatic cancer (PC). This is the first investigation to elucidate the impact on tumorigenesis and prognostic value of NOP10 in pancreatic adenocarcinoma (PAAD).
METHOD: NOP10 expression and its survival prognostic significance were analyzed via clinical PAAD data from the TCGA database and NOP10 expression in other tumors from the GEPIA database. Furthermore, the NOP10 expression and survival prognosis in clinical samples were validated by qRT-PCR. In-vitro experiments were carried out to elucidate the impact of NOP10 on the biological function of PC cells.
RESULTS: It was revealed that NOP10 expression was increased in PC tissues than in the normal pancreatic tissues. High NOP10 expression was markedly linked with poorer prognosis. NOP10 may be involved in focal adhesion, channel activity, cAMP signaling pathway, the interaction of neuroactive ligand-receptor, and cell adhesion molecules cams. NOP10 was associated with the tumour immune microenvironment and drug sensitivity. Down-regulation of NOP10 expression suppressed PC cells' ability to proliferate, migrate, and invade.
CONCLUSIONS: This investigation elucidated the prognostic and predictive importance of NOP10 in PAAD and revealed that NOP10 is associated with poor prognostic features, survival prognosis and TIME. Knockdown of NOP10 inhibits the progression of PAAD.
Vibrio spp. are major pathogens responsible for mortality and disease in various marine aquaculture organisms. Effective disease control and genetic breeding strategies rely heavily on understanding host vibriosis resistance mechanisms. The Chinese tongue sole (Cynoglossus semilaevis) is economically vital but suffers from substantial mortalities due to vibriosis. Through continuous selective breeding, we have successfully obtained vibriosis-resistant families of this species. In this study, we conducted RNA-seq analysis on three organs, including liver, spleen and intestine from selected resistant and susceptible tongue soles. Additionally, we integrated these data with our previously published RNA-seq datasets of skin and gill, enabling the construction of organ-specific transcriptional profiles and a comprehensive gene co-expression network elucidating the differences in vibriosis resistance. Furthermore, we identified 12 modules with organ-specific functional implications. Overall, our findings provide a valuable resource for investigating the molecular basis of vibriosis resistance in fish, offering insights into target genes and pathways essential for molecular selection and genetic manipulation to enhance vibriosis resistance in fish breeding programs.