anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a composition effective for suppressing the elevation of blood pressure by using a caseinoglycopeptide as an active component. CONSTITUTION:Caseinoglycopeptide (abbreviated to 'CGP') which is a glycopeptide existing in cheese whey, whey protein, whey mineral, etc., is used as an active component. In the case of using CGP as an agent for suppressing the elevation of blood pressure, it is preferably administered by peroral administration at a daily dose of 1-10g for adult. CGP can be administered by adding to a food such as cake, ice cream, yogurt and sport drink or to a feed for livestock or pet. Since CGP is originated from whey which as a useful food raw material, it has extremely high safety. The effect is further promoted by using CGP in combination with potassium.
Use of rufinamide has been associated with central nervous system-related adverse reactions in the controlled clinical trial of patients 4 years or older with Lennox-Gastaut Syndrome. The most significant of these can be classified into two general categories: 1) somnolence or fatigue, and 2) coordination abnormalities, dizziness, gait disturbances, and ataxia.   
Somnolence was reported in 24% of rufinamide-treated patients compared to 13% of patients on placebo, and led to study discontinuation in 3% of rufinamide-treated patients compared to 0% of patients on placebo. Fatigue was reported in 10% of rufinamide-treated patients compared to 8% of patients on placebo patients. It led to study discontinuation in 1% of rufinamide-treated patients and 0% of patients on placebo patients.   
Dizziness was reported in 2.7% of rufinamide-treated patients compared to 0% of patients on placebo, and did not lead to study discontinuation.   
Ataxia and gait disturbance were reported in 5.4% and 1.4% of rufinamide-treated patients, respectively, compared to no patient on placebo. None of these reactions led to study discontinuation.   
Accordingly, patients should be advised not to drive or operate machinery until they have gained sufficient experience on rufinamide to gauge whether it adversely affects their ability to drive or operate machinery.
The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide. Groups of C57BL/6J mice were fed 1 of 3 diets: a modified AIN-93G diet with a moderate level of fat (control; CO), CO with milk gangliosides (GG), and CO with milk polar lipids (MPL). The MPL diet did not prevent a gut permeability increase upon LPS stress but increased the expression of tight junction proteins zonula occludens-1 and occludin in the colon mucosa. The GG diet prevented the gut permeability increase upon LPS stress. The MPL diet decreased absolute and relative liver mass and decreased hepatic gene expression of acetyl-CoA carboxylase 2 and 3-hydroxy-3-methylglutaryl-CoA reductase. The GG diet increased hepatic gene expression of acetyl-CoA acyltransferase 2. Overall, milk GG protected the intestinal barrier integrity but had little effect on systemic inflammation and lipid metabolism; conversely, milk MPL had complex effects on gut permeability, did not affect systemic inflammation, and had a beneficial effect on hepatic lipid metabolism.
PRIMARY OBJECTIVES: I. To examine the anti-tumor activity and safety of administering ex vivo expanded T cells that are genetically modified using a self-inactivating (SIN) lentiviral vector to express a co-stimulatory CD123-specific chimeric antigen receptor (CAR) as well as a truncated EGFR (CD123CAR-CD28-CD3zeta-EGFRt+ T cells \[CD123+ CAR T cells\]) following lymphodepletion for patients with CD123+ relapsed or refractory acute myeloid leukemia (AML) (arm 1), or CD123+ persistent or recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) (arm 2). II. To determine the recommended Phase II dose (RP2D) for both arms (AML and BPDCN). SECONDARY OBJECTIVES: I. To assess activity in the form of CD123+ CAR T cell persistence, 6 month progression free survival (PFS 6mo) rate, and 1 year overall survival (OS) rate, and describe the immunogenicity of CD123R(EQ)28zeta/EGFRt+ T cells. TERTIARY OBJECTIVES: I. To assess impact on hematopoiesis, change from baseline in numbers of CD123+ blood cells, CD123 expression on malignant cells and hematopoietic cells, and the clinical efficacy of EGFRt mediated CAR T cell ablation.

OUTLINE: This is a dose-escalation study of autologous or allogeneic (related or unrelated donor) CD123+ CAR T cells. Patients undergo a lymphodepleting regimen 3-10 days prior to CD123+ CAR T cell infusion as determined by the principal investigator and the protocol team. Patients receive either cyclophosphamide intravenously (IV) on days -4 and/or -3; fludarabine phosphate and cyclophosphamide IV on days -5 to -3; fludarabine phosphate IV on days -5 to -3 and cyclophosphamide IV on days -4 and/or -3. Patients receive autologous or allogeneic CD123+ CAR T cells IV over 15 minutes on day 0. Patients with evidence of disease at \> 28 days, continuing expression of the CD123 antigen, and not having experienced a dose-limiting toxicity (DLT) may receive a second infusion of CD123+ CAR T cells after 28 days. After completion of study treatment, patients are followed up at 24 hours, then every 2 days for up to 14 days, every week for 1 month, every month for 1 year and then yearly for 15 years.
BACKGROUND: Soft tissue sarcomas (STS) constitute a heterogeneous group of rare tumor entities. Treatment relies on challenging patient-tailored surgical resection. Real-time intraoperative lipid profiling of electrosurgical vapors by rapid evaporative ionization mass spectrometry (REIMS) may aid in achieving successful surgical R0 resection (i.e., microscopically negative-tumor margin resection). Here, we evaluate the ex vivo accuracy of REIMS to discriminate and identify various STS from normal surrounding tissue.
METHODS: Twenty-seven patients undergoing surgery for STS at Maastricht University Medical Center+ were included in the study. Samples of resected STS specimens were collected and analyzed ex vivo using REIMS. Electrosurgical cauterization of tumor and surrounding was generated successively in both cut and coagulation modes. Resected specimens were subsequently processed for gold standard histopathological review. Multivariate statistical analysis (principal component analysis-linear discriminant analysis) and leave-one patient-out cross-validation were employed to compare the classifications predicted by REIMS lipid profiles to the pathology classifications. Electrosurgical vapors produced during sarcoma resection were analyzed in vivo using REIMS.
RESULTS: In total, 1200 histopathologically-validated ex vivo REIMS lipid profiles were generated from 27 patients. Ex vivo REIMS lipid profiles classified STS and normal tissues with 95.5% accuracy. STS, adipose and muscle tissues were classified with 98.3% accuracy. Well-differentiated liposarcomas and adipose tissues could not be discriminated based on their respective lipid profiles. Distinction of leiomyosarcomas from other STS could be achieved with 96.6% accuracy. In vivo REIMS analyses generated intense mass spectrometric signals.
CONCLUSION: Lipid profiling by REIMS is able to discriminate and identify STS with high accuracy and therefore constitutes a potential asset to improve surgical resection of STS in the future.
Participants will receive and be instructed to follow-along with 4 weeks of movement-to-music videos. Participants will also receive periodic behavioral coaching calls from a telecoach.
INTRODUCTION: Patients treated with immunotherapy might need surgical procedures in addition to the medical treatment. The main indications are cytoreductive nephrectomy, cystectomy (as part of clinical trials) and metastasis removal in some oligometastatic patients. This study aims to assess the feasibility of surgery for patients treated by immunotherapy and describes the histological modifications found in the pathological analysis.
MATERIAL AND METHODS: We conducted a retrospective, monocentric study. We included all patients operated for a urologic cancer and previously treated with systemic immunotherapy between February 2018 and June 2022. We compared this population with a control group of patients treated with surgery without having previous immunotherapy. Patients were compared according to the cancer type, age and sex. We compared perioperative complications. We performed an analysis for evaluation of the peri-tumoral inflammatory infiltration.
RESULTS: We included 50 patients in this study. The two groups were comparable in age (63.7 vs. 63.3years old, P=0.95) and sex (4 and 6 women in the first and second group). The peroperatory complication rate was comparable (20% vs. 16%, P=1). The mean bleeding volume was comparable (664 vs. 629mL; P=0.89). The postoperative complication rate (48% vs. 56%; P=0.78) and their grade (Clavien III-IV 8% vs. 24%; P=0.24) were comparable. The anatomopathological analysis described the same rate and intensity of peri-tumoral inflammatory infiltrate (96% vs. 96%; P=1).
CONCLUSIONS: Preoperative immunotherapy does not appear to be associated with increased surgical difficulty and perioperative complications. Blind histological analysis of the surgical specimens did not reveal any specific features related to pre operative immunotherapy.
LEVEL OF EVIDENCE: Grade 3 HAS.
Participants without suboptimal health status are randomly grouped into the group without monitor (Group 1) and the monitor group (Group 2 or Group 3). Thus, no monitoring or intervention technologies are used in Group 1.
<P>PROBLEM TO BE SOLVED: To provide a method of inducing human hair growth in a non-human animal by transplanting mixed cells including human cells, to provide a non-human animal having human hair grown by the method and to provide a screening method using the animal.  <P>SOLUTION: In the skin of a non-human animal, hair growth is induced from the hair follicle structure including human-originating cells. Dermal papilla cells, epidermal cells and dermal fibroblasts (at least one of them originates from a human) are mixed and the mixture is transplanted to the skin of a non-human animal whereby the growth of human hair is in vivo induced on the skin. A non-human animal that has human hair grown on its skin. In addition, screening process for hair growth factor and the like including the process that the factors to be tested are brought into contact with the non-human animals and the evaluation method for the activity of the factors.  <P>COPYRIGHT: (C)2003,JPO
Pono Choices: A Culturally Responsive Teen Pregnancy and STI Prevention Program for Middle School Youth in Hawaii. The program includes 9.5 hours of scripted lessons or modules.
If the participant volunteers to participate in this study, after signing the informed consent, responses to background data - age, gender, height, weight, wrist circumference of dominant arm, history of high blood pressure, diabetes, high cholesterol and cardiovascular disease - will be collected; The BPI will be strapped to the right or left wrist making sure it is comfortable to the participant and the readings from the BPI will be recorded in a computer. The continuous BPI readings will be recorded for 2 minutes. Simultaneously, blood pressure readings will be obtained from a cuff-based, commercially available blood pressure measuring device placed in the same arm. The research team will take a minimum 3 and maximum 6 sets of readings. At the end of the BPI readings, we will place an ultrasound probe of the wrist at the level of the wrist to assess the size of the radial artery and depth of the artery from the skin.

Participant Timeline: The collection of the background data will take 5 to 10 mins. The placement of the BPI and cuff-blood pressure device and the data collection will take about 15 to 20 mins. The ultrasound image collection will 10 to 15 mins. Overall, the study procedures will be less than an hour.
Over the past 30 years, research has increasingly focused on the impact of religious practices on stress reduction. The Islamic prayer (salaat) is a mind-body practice consisting of a movement component and a meditative component. Although Weigand and colleagues (2004) and others (Archour \& Roslan, 2014; Archour, Muhamad, Syihab, Mohd, \& Mohd, 2021) have demonstrated robust negative associations between the practice of the Muslim prayer form (salaat) and anxiety. More recently, Doufesh and colleagues (2012; 2014; 2018) have examined the effect of salaat on central nervous system (CNS) and cardiovascular functioning. These studies have demonstrated improved physiological relaxation as reflected in increased alpha wave activity and high frequency heart rate variability (HF-HRV) among men. To date, existing studies that have focused on the relationships of salaat with anxiety and cardiovascular functioning have been mostly single group, observational designs. The only prior study with a control condition utilized a resting state comparison group rather than a true sham condition (Gao et al., 2019). Also, past studies have focused almost exclusively on Muslim men. Finally, research has documented the harmful effects of discrimination on automatic nervous system (ANS) functioning on racial and ethnic minorities (Nikolova, Tzacheva, \& Vodenitcharov, 2011). However, a paucity of research has examined the relationship of salaat and ANS functioning among Muslim women or Muslimahs reporting experiences of perceived discrimination. This is particularly important as discrimination reported by Muslim women is positively associated with their visibility, e.g., greater adherence to Islamic practices such as the traditional headscarf and wearing loose clothing in public spaces is associated with increased experience of discrimination (Ali, Elsayed, Elahi, Zia, \& Awaad, 2022). Thus, this study was designed to evaluate the influence of the recitation component of salaat on ANS functioning among visible Muslim women using a sham control condition. In addition, this study will explore the degree to which perceived discrimination is associated with physiological markers of stress and with health behaviors among Muslim women. Thus, this study aims to replicate and expand upon previous research demonstrating that alpha wave activity during EEG recordings can be found during the salaat.
PROBLEM TO BE SOLVED: To prepare a cosmetic and a toilet lotion, excellent in touch and having sterilizing effects without causing skin roughening by adding an alkali to an acidic aqueous solution containing two specific kinds of ions, regulating the pH within a specific range and formulating the resultant sterilizing aqueous solution therein. SOLUTION: The cosmetic and toilet lotion are prepared by adding an alkali to an acidic aqueous solution containing iodide ions and manganese ions, regulating the pH to 2.5-7.0 and including the resultant sterilizing aqueous solution therein. The iodide ions and the manganese ions are preferably formulated at (10:1) to (1:30) ratio. The acidic aqueous solution containing the iodide ions and manganese ions is obtained by dissolving, e.g. a compound dissociating into the iodide ions in the aqueous solution and a compound dissociating the manganese ions in the aqueous solution in an acid liquid prepared by adding an acid to water. Manganese sulfate and manganese chloride are preferred as the manganese ions and an alkali metallic iodide is preferred as the iodide ions.
Gadopiclenol is a new macrocyclic gadolinium-based contrast agent (GBCA) which has higher relaxivity than other GBCAs with a potential use of lower dose and comparable pharmacokinetics to other agents in preclinical studies. In a rodent model of liver metastasis, gadopiclenol showed strong enhancement with comparable pharmacokinetics to other extracellular GBCAs (EC-GBCAs). It was found to have a potential of either improving lesion conspicuity or providing similar accuracy in lesion detection with a reduced Gadolinium (Gd) dose. In a rat brain tumor model, half dose (0.05 mmol/kg) of gadopiclenol yielded comparable contrast-to-noise ratio (CNR) and morphological characterization of brain tumors compared to other EC-GBCAs. There are also a few clinical studies in which no safety concern was raised with the use of gadopiclenol. No dose adjustment for children or patients with renal impairment was found to be required. There is no study in the literature assessing the enhancement properties of gadopiclenol in abdominal imaging and comparing it with a hepatobiliary agent for image quality and lesion detection/conspicuity in the liver. For this study, it is hypothesized that dynamic imaging using Gadopiclenol is noninferior to gadoxetate MRI in terms of image quality and lesion detection/conspicuity.
Methods of treatment of sepsis are disclosed. These methods comprise administering to a subject a composition comprising at least one siRNA directed against at least one gene encoding a pro-apoptotic polypeptide. The pro-apoptotic polypeptide, in some aspects, can be other than Fas or caspase-8. In some embodiments, an siRNA can be directed against a pro-apoptotic component of the mitochondrial pathway, such as a pro-apoptotic bcl-2 protein. In some aspects, an siRNA can be directed against a BH3-only bcl-2 protein, while in other aspects, siRNAs can be directed against multi BH domain Bcl-2 family members such as bax and bak. In some embodiments, an siRNA can be directed against a death receptor pathway molecule such as FADD. In various configurations, a composition can also comprise a cationic lipid such as DOTAP, or nanoparticles comprising a cyclodextrin-containing polycation and a polymer such as a poly(ethylene glycol).
After the screening/washout period, all participants will receive study drug NT0102 once daily for 4 weeks during the dose optimization period. After completion of the dose optimization period, the optimized dose of the study drug will be selected, and participants will stay on that dose for 1 week (dose stabilization period). At the end of this period, participants will be randomized to a treatment. Participants in this arm will be given 20-60 mg of NT0102 as oral disintegrating tablet (ODT) once daily for one week during the double-blind treatment period.
This is a randomized controlled trial. In cooperation with Alberta Bone and Joint Health Institute (ABJHI), patients who have been deemed to be hip or knee joint arthroplasty candidates at the time of the initial assessment by the ABJHI musculoskeletal physician will be invited to participate. With the candidate's consent, they will be contacted by the study team, provided with additional information and an informed consent will be signed.

Participants will be randomized (by the project coordinator via computer generated simple randomization schedule) into either an active treatment (a single BMAC injection into the arthritic joint; n=75) or conservative care group (awaiting arthroplasty; n=75). The treatment group will receive their BMAC injection within 2 weeks of signing their consent form. 60 mL of bone marrow will be aspirated from the iliac crest of each subject in the active treatment group. The bone marrow aspirate (BMA) will be centrifuged using a single spin protocol such that the red blood cells are minimized and the total nucleated and platelet cells are concentrated into a 12 mL volume of bone marrow aspirate concentrate (BMAC). Two mL of BMA and BMAC will be retained for cellular analysis (total nucleated cells, platelet and hematocrit) injectate description purposes. Ten mL of BMAC will then be injected into the arthritic hip or knee. The bone marrow aspiration and joint injection will be done under local anesthesia, sterile technique and ultrasound or fluoroscopic guidance by a practitioner with ultrasound and fluoroscopy training/credentialing in an accredited Nonhospital Surgical Facility operating room in compliance with the College of Physicians and Surgeons of Alberta's (CPSA) Stem Cell Regenerative Therapy Standards. Each group will be allowed to take their usual analgesic medications (with the exception of the treatment group who will be asked to avoid NSAID intake for one week prior to and four weeks following their injection), receive their usual conservative treatments and each will be given the same activity instructions by ABJHI.

The active treatment group will be contacted by telephone within 3 days of their BMAC injection to monitor recovery and record and respond to any adverse events. Other outcome measures will be followed for 12 months (or until their joint arthroplasty surgery if prior to 12 months) and will be recorded by ABJHI who will be blinded to which treatment group the subjects are assigned. Outcome Measures will be measured in person at the time of enrollment into the study and at 6 months following post-treatment or non-treatment. At 3- and 12-months post, outcomes measures will be completed electronically or by phone. Only the assessor(s) will be blinded to the group assignment whereas the patient and the physician providing the treatment will be unblinded.
The invention discloses a traditional Chinese medicinal composition for treating cervical spondylopathy, and preparation methods thereof, and relates to the technical field of traditional Chinese medicinal compositions. The traditional Chinese medicinal composition comprises Psoralea corylifolia, rhizoma drynariae, Berchemia floribun-da(Wall.) Brongn., sappan wood, Prismatomeris tetrandra, semen cuscutae, Zaocys Dhumnades, Caulis Spatholobi, Radix Fici Hirtae, Cynanchum paniculatum, Salvia miltiorrhiza, cassia twig, cinnamon, Radix Aucklandiae and mirabilite. The preparation method 1 of the traditional Chinese medicinal composition comprises the following steps: crushing traditional Chinese medicinal raw materials, dipping obtained crude powders of Psoralea corylifolia, rhizoma drynariae, Berchemia floribun-da(Wall.) Brongn., sappan wood, Prismatomeris tetrandra, semen cuscutae, Zaocys Dhumnades, Caulis Spatholobi, Radix Fici Hirtae, Cynanchum paniculatum and Salvia miltiorrhiza, filtering the obtained dipping solution to obtain a filtrate, adding crude powders of cassia twig, cinnamon, Radix Aucklandiae and mirabilit to the filtrate, dipping the crude powders of cassia twig, cinnamon, Radix Aucklandiae and mirabilit, filtering the obtained solution to obtain a filtrate, and concentrating the filtrate. The preparation method 2 of the traditional Chinese medicinal composition comprises the following steps: crushing traditional Chinese medicinal raw materials, percolating and extracting the crushed raw materials with ethanol, and concentrating the obtained leachate. The traditional Chinese medicinal composition combining the above fifteen traditional Chinese medicines can solve cervical vertebra strains, strengthen muscles and bones, free channels and activate collaterals, has the advantages of simple and convenient use and low side effects, and has a cure rate of 91.6%.
Participants will be supplied with 2 main meals per day as part of their daily diet, for 6 days a week. This diet is prescribed as a moderate energy restriction (500-1000 kcal/day) to facilitate weight loss. Additional food products are supplied for breakfast and snacks. Participants will receive individual diet consultations with the study dietitian during the study. Participants are told to consume only low-fat dairy products (milk, yoghurt), and avoid ruminant meat (beef, lamb), cheese, butter, butter-containing food products, and sugar-sweetened beverages.
Ringer's solution 12ml/kg. Intravenous injection twice (24 hours、1 hour before operation).