anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION AND AIM: Chronic pancreatitis is a pathologic fibroinflammatory syndrome of the pancreas. Treatment includes medical management and endoscopic and/or surgical interventions. Our aim was to describe progression in patients with chronic pancreatitis whose initial management was either endoscopic or surgical.
MATERIAL AND METHODS: A retrospective, analytic, observational, and longitudinal study was conducted that included patients diagnosed with chronic pancreatitis treated at the Hospital de Especialidades of the Centro Médico Nacional Siglo XXI from 2015 to 2021.
RESULTS: Twenty-two patients were included in the study; 12 underwent endoscopy and 10 underwent surgery. The mean number of interventions performed was 3 in the endoscopic management group and 1.1 in the surgical management group (p = 0.001). Regarding pain remission (partial or total), results were statistically significant in favor of surgical management (p = 0.035). Of the 12 patients that initially underwent endoscopy, 7 (58.3%) eventually required surgery during follow-up. There were no statistically significant differences with respect to opioid and pancreatin use, readmissions, weight loss, steatorrhea, newly diagnosed diabetes, or deaths during follow-up.
CONCLUSION: Pain is the main indication for invasive treatment, whether endoscopic or surgical, in patients with chronic pancreatitis. Slightly more than half of the patients that were initially managed endoscopically required surgery during follow-up. Management decisions should be multidisciplinary and individualized for each patient.
PCT No. PCT/EP94/01065 Sec. 371 Date Sep. 29, 1995 Sec. 102(e) Date Sep. 29, 1995 PCT Filed Apr. 6, 1994 PCT Pub. No. WO94/24299 PCT Pub. Date Oct. 27, 1994Viruses or cells are targeted for selective internalization into a target in vive. A molecule Specific for a receptor on the surface of the target cell is introduced onto the surface of the virus or cell. The modified virus or cell binds the receptor in vive and is internalized by the target cell. The method provides vectors for selective delivery of nucleic acids to specific cell types in vivo and a means to alter the tropism of an infectious agent.
Healthy non-pregnant adult women 18-49 years of age received a single dose of dTpa vaccine at Day 1 and were scheduled to receive a single dose of RSV MAT vaccine at Day 31 and to be followed-up until end of study (180 days post-vaccine administration). RSV MAT vaccine was no longer administered to participants at Day 31.
OBJECTIVE: To assess the relationship among measurements of strength, function, and quality of life in an amyotrophic lateral sclerosis (ALS) clinical trial.
METHODS: In the FORTITUDE-ALS clinical trial (NCT03160898), 456 participants in the full-analysis set were treated with either reldesemtiv or placebo for 12 weeks; this post hoc analysis included all participants regardless of treatment assignments. Assessments included slow vital capacity (SVC), the ALS Functional Rating Scale-Revised (ALSFRS-R), and the 5-item ALS Assessment Questionnaire (ALSAQ-5). Muscle strength was measured quantitatively with hand-held dynamometry, and grip strength with a dedicated dynamometer. The relationship between strength and ALSFRS-R fine and gross motor domain scores, or responses to ALSAQ-5 questions on hand function and walking, was assessed with Spearman's rank correlation. The relationship between mean upper- or lower-extremity muscle strength and specific ALSFRS-R domains was modeled using principal-components analysis.
RESULTS: Upper-extremity muscle strength and hand grip were highly correlated with ALSFRS-R fine motor scores and the ALSAQ-5 hand function question. Similarly, lower-extremity strength correlated well with ALSFRS-R gross motor domain and the ALSAQ-5 walking question. For SVC, correlation was poor with the ALSFRS-R respiratory domain, but stronger with the total score, potentially reflecting the insensitivity of the respiratory questions in the scale. Upper- and lower-extremity strength were both strong predictors of ALSFRS-R domain scores.
CONCLUSIONS: In this analysis of data from an ALS clinical trial, muscle strength quantified by dynamometry was strongly correlated with functional capacity. These results suggest that muscle strength directly relates to specific functions of importance to people with ALS.
Residents of malaria-endemic regions are frequently exposed to a variety of other parasites concurrently with malarial parasites. In Mali, lymphatic filariasis due to Wuchereria bancrofti co-exists in several regions highly endemic for malaria, and co-infection is common in the residents of these areas. Because of the chronicity of filarial infections and an associated bias towards the development of an adaptive immune response dominated by Th2 cytokines, a pre-existing filarial infection has the potential to alter the immune response towards incoming malarial parasites, clearance of which are considered to be dependent on a robust Th1 response. This could, in turn, affect the clinical manifestations and outcomes of malaria infection. Conversely, immune responses to filarial parasites may be modulated in the presence of malarial parasites. In addition to sharing a human host, Plasmodium falciparum and Wuchereria bancrofti are transmitted by the same mosquito vector, Anopheles gambiae, and interaction between the two species in the vector may have important implications for transmission of these two infections. The primary goals of this study are to determine the effect of concurrent infections with P. falciparum and W. bancrofti parasites on the prevalence and severity of malaria infection in children living in a Malian village co-endemic for two parasites and to assess the effects of co-infection on the immune responses to these two parasites over the course of the malaria transmission season. The epidemiology of co-infection at the human and vector level will also be examined.
Obesity and weight gain represent a challenging issue in people suffering from schizophrenia and other severe mental illnesses (SMI). Most of clinical guidelines for the management of overweight and obesity in people with SMI share a stepwise approach starting with more conservative interventions, with diet, physical activity, lifestyle coaching and behavioral modifications. The aim of this study was to evaluate the effectiveness of a group weight management program in a real-world outpatient Italian setting. Data from 100 patients diagnosed with schizophrenia or bipolar disorder, undergone to a group metabolic management program, were analyzed through a 12 months follow-up. The main body weight (kgs) decreased from 98.01±18.30 at baseline to 93.29±17.36 (p>0.001) at 6 months to 90.35±17.90 at 12 months. Parallel statistically significant decreases were found for BMI, waist circumference, glycaemia and systolic blood pressure. After patients' segmentation into normal-weight, overweight and obese at baseline, the significant of the decrease emerged only between baseline and the 6-month endpoint, thus suggesting that the program was successful in the short-term. Notwithstanding the limitations of the study, the 12-month intervention evaluated demonstrated feasibility and a high retention rate. This allowed a relevant weight reduction during the first six months, followed by durable maintenance until the end of the study. Current NICE recommendation guidance indicates that people with SMI, particularly those on antipsychotic treatment, should be provided with integrated nutrition and exercise programmes by their healthcare professional. Future research should focus on the effectiveness and cost-effectiveness of this kind of interventions and their reliability in the different real-world healthcare settings.
The invention discloses an in-vitro three-dimensional cultivation model for hydatid cysts and application thereof. The model used for cultivating the hydatid cysts comprises a cultivating pond and a three-dimensional collagen scaffold arranged in the cultivating pond. The three-dimensional collagen scaffold is loaded with feeder cells. The feeder cells are primary parenchymal hepatic cells and bone mesenchymal stem cells. Bio-culture solutions are contained in the cultivating pond and are solutions used for cultivating the hydatid cysts and the feeder cells. The in-vitro three-dimensional cultivation model for the hydatid cysts can be used for researching the development process of the hydatid cysts; by means of the model, immunofluorescent staining observation, electron microscope detection and RT-PCR analysis can be performed on host cells and parasite tissue cells in the three-dimensional collagen scaffold, correlational researches on in-vitro long-time cultivation and development of the hydatid cysts are achieved, and compared with an existing cultivation model for the hydatid cysts, remarkable progress is made.
Critically ill patients often experience a dysregulated immune response, leading to immune dysfunction. Sepsis, trauma, severe infections, and certain medical conditions can trigger a state of systemic inflammation, known as the cytokine storm. This hyperactive immune response can cause collateral damage to healthy tissues and organs, exacerbating the patient's condition. On the other hand, some critically ill patients may suffer from immune paralysis which can increase the risk of nosocomial infections.Fever is an evolutionary adaptation that evolved as an effective defense mechanism to fight invading pathogens. By raising body temperature, fever enhances the immune response, inhibits pathogen growth, promotes recovery, and aids in the formation of immune memory. Understanding the role of fever in the context of immune defense is crucial for optimizing medical interventions and supporting the body's natural ability to combat infections.Future Directions: Advancements in immunology research and technology hold promise for better understanding the immune system's complexities in critically ill patients. Personalized medicine approaches may be developed to tailor therapies to individual patients based on their immune profile, optimizing treatment outcomes. Based on recent studies prognostic parameters such as lymphocyte count, IL-10 concentration and mHLA-DR expression can be used to stratify the immunological response pattern in septic patients.Conclusion: The immune system's response in critically ill patients is a multifaceted process, involving intricate interactions between various immune cells, cytokines, and organs. Striking the delicate balance between immune activation and suppression remains a significant challenge in clinical practice. Continued research and therapeutic innovations are vital to improve patient outcomes and reduce the burden of critical illness on healthcare systems.
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored.
METHODS: CHIP prevalence was determined in the UK Biobank, and incident AF analysis was stratified by CHIP status and clone size using Cox proportional hazard models. Lethally irradiated mice were transplanted with hematopoietic-specific loss of Tet2, hematopoietic-specific loss of Tet2 and Nlrp3, or wild-type control and fed a Western diet, compounded with or without NLRP3 (NLR [NACHT, LRR {leucine rich repeat}] family pyrin domain containing protein 3) inhibitor, NP3-361, for 6 to 9 weeks. Mice underwent in vivo invasive electrophysiology studies and ex vivo optical mapping. Cardiomyocytes from Ldlr-/- mice with hematopoietic-specific loss of Tet2 or wild-type control and fed a Western diet were isolated to evaluate calcium signaling dynamics and analysis. Cocultures of pluripotent stem cell-derived atrial cardiomyocytes were incubated with Tet2-deficient bone marrow-derived macrophages, wild-type control, or cytokines IL-1β (interleukin 1β) or IL-6 (interleukin 6).
RESULTS: Analysis of the UK Biobank showed individuals with CHIP, in particular TET2 CHIP, have increased incident AF. Hematopoietic-specific inactivation of Tet2 increases AF propensity in atherogenic and nonatherogenic mouse models and is associated with increased Nlrp3 expression and CaMKII (Ca2+/calmodulin-dependent protein kinase II) activation, with AF susceptibility prevented by inactivation of Nlrp3. Cardiomyocytes isolated from Ldlr-/- mice with hematopoietic inactivation of Tet2 and fed a Western diet have impaired calcium release from the sarcoplasmic reticulum into the cytosol, contributing to atrial arrhythmogenesis. Abnormal sarcoplasmic reticulum calcium release was recapitulated in cocultures of cardiomyocytes with the addition of Tet2-deficient macrophages or cytokines IL-1β or IL-6.
CONCLUSIONS: We identified a modest association between CHIP, particularly TET2 CHIP, and incident AF in the UK Biobank population. In a mouse model of AF resulting from hematopoietic-specific inactivation of Tet2, we propose altered calcium handling as an arrhythmogenic mechanism, dependent on Nlrp3 inflammasome activation. Our data are in keeping with previous studies of CHIP in cardiovascular disease, and further studies into the therapeutic potential of NLRP3 inhibition for individuals with TET2 CHIP may be warranted.
The placebo control group will be immunised three times with saline i.m. at weeks 0,4, and 8. Participants will be exposed to 20 male Schistosoma mansoni cercariae at week 12.
The invention discloses a loxoprofen organic amine salt transdermal patch and a preparation method thereof and belongs to the technical field of medicine. The loxoprofen organic amine salt transdermal patch is composed of a backing layer, a medicine storage cavern layer and an anti-sticking layer, wherein the medicine storage cavern layer mainly comprises loxoprofen organic amine salt, pressure-sensitive adhesive and percutaneous absorption enhancer. The dosage of loxoprofen takes up 1%-30wt% of pressure-sensitive adhesive solid content, and the dosage of percutaneous absorption enhancer takes up 1%-30wt% of the pressure-sensitive adhesive solid content. The loxoprofen organic amine salt transdermal patch synthetizes organic amine salt through the loxoprofen to effectively improve percutaneous transit dose, administration dosage can be controlled by adjusting dosing area, medicine is continuously and stably released during 24 hours, and accordingly curative effect is durable and stable. If dosing is required to be suspended, users only need to uncover the patch, and accordingly usage is convenient. The transdermal patch is good in curative effect, little in side effect, good in permeability and high in safety and treatment compliance of patients.
PCT No. PCT/AU95/00536 Sec. 371 Date May 14, 1997 Sec. 102(e) Date May 14, 1997 PCT Filed Aug. 25, 1995 PCT Pub. No. WO96/06185 PCT Pub. Date Feb. 29, 1996The present invention relates to a method of detecting the presence of an active protease in a sample. The method involves the following steps: (1) providing a solid support to which is attached a ligand reactive with a protease; (2) contacting the solid support with a sample suspected to contain the protease; (3) washing the solid support to remove material not bound to the ligand; (4) contacting the washed solid support with a solution containing a peptide ester substrate which is hydrolysed for the protease, and (5) detecting protons produced by hydrolysis of the peptide ester substrate. In addition, the present invention provide a prostate specific antigen substrate, the substrate being of the general formula; A-B-Tyrosine-ester in which A is acetyl or carbobenzoxy and B is 2 to 6 amino acids.
PURPOSE: To provide a medicine compsn. which contains cyclophosphamide and pregelatinized starch and may be directly compressed. CONSTITUTION: The cyclophosphamide and the partially or completely pregelatinized starch are incorporated as effective components into the compsn. The pregelatinized starch contains 15 wt.% free amylopectin, 5 wt.% free amylose and 80 wt.% non-denatured corn starch. The cyclophosphamide and the pregelatinized starch are incorporated at a weight ratio of 2:1 into the compsn. A diluting agent, disintegrator, lubricant, glydant, etc., are properly compounded therewith at need and the mixture is deflocculated by dry process screening using a rotary granulator and is compressed to form core tablets. The core tablet blend is coated by a second compression coating by which the directly compressed tablets having the high stability of the cyclophosphamide are obtd.
PERIODONTAL SURGICAL INTERVENTION:The first arm is the simplified papilla preservation flap (SPPF) surgery.At visit 3, the SPPF surgery is performed. 2D and 3D imaging on surgical site will be carried out pre and post surgery. 2D and 3D imaging performed on surgical site for all post operative visits.
Patients over 18 years old with advanced cancer defined as metastatic disease, no curable treatment options. The patients may not have received chemotherapy or irradiation within 4 weeks, no operations within 2 weeks and no general anesthesia within 4 days.
The control arm will receive thymoglobulin induction and tacrolimus-based immunosuppressive therapy. The dose of thymoglobulin would be 1.0mg/kg/d for 3 days25. The first dose of thymoglobulin will be administered before graft kidney reperfusion, and so is rituximab. All patients will receive corticosteroid therapy as usual. The initial daily dose of tacrolimus will be 0.15 mg/kg/d given in two doses starting within 24 hours after transplantation. The doses of tacrolimus will be adjusted to target the whole blood trough levels between 8 to 12 ng/ml during the first 30 days after transplantation, and tapered to 6 to 10 ng/ml at 6 months.
Perfluorobutane sulfonate is a short-chain PFAS that is a less toxic replacement for the rather more toxic long-chain perfluorooctane sulfonate. PFBS is widespread in the environment and has raised environmental and health concerns. The study goal was to investigate whether dietary ingestion of PFBS would induce hepatic damage. Sprague-Dawley rats were assigned to three PFBS treatment groups for 11 weeks followed by clinical markers analyses in the serum and liver. There was a significant increase in liver and body weights of PFBS rats. Total antioxidant capacity was significantly reduced in the PFBS-treated group. ALT levels increased based on concentration ingested. Close to 1000 gene transcripts were differentially expressed. Further, transmembrane transport and oxidation-reduction processes were the most up-regulated biological processes. Inflammatory genes were up-regulated in the exposed group and those associated with oxidative damage were down-regulated. In conclusion, PFBS ingestion produced mild effects in the liver of Sprague Dawley rats.
PURPOSE:To obtain the titled factor by adding a protease-inhibitor to a medium in the culture of a cell producing a colony stimulating factor. CONSTITUTION:The objective CSF can be produced by culturing a colony stimulating factor-producing cell (CSF) (human plumonary calcinoma cell TLC-9A, human renal carcinoma cell TRC-29R, etc.) in a proper medium (e.g. Eagle's MEM, alpha-MEM, Iscob medium, etc.) added with a protease-inhibitor (e.g. animal tissue-originated inhibitor such as alpha1-proteinase inhibitor, vegetable tissue-originated inhibitor such as soybean trypsin inhibitor, or a microorganism- originated inhibitor such as streptomyces subtilisin inhibitor, etc.) in an amount of preferably >=0.001%. EFFECT:The separation and purification of CFS from the culture liquid can be remarkably facilitated, and a high-purity CFS can be produced. The factor is expected to be applicable as a remedy for hypoleukocytosis.
INTRODUCTION: Effective pain and anxiety management during the perioperative phase remains a challenge for patients undergoing surgeries and other invasive procedures. The current standard of care involves prescribing analgesics to treat these conditions; however, there has been recent interest in applying multimodal strategies that limit the use of these medications. One such modality is meditation, which has been shown to be effective in alleviating various physical and psychological symptoms in other settings. This systematic review aims to assess how current meditative practices affect perioperative pain and anxiety.
METHODS: We conducted a systematic review of randomized controlled trials following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was conducted using PubMed MEDLINE, Embase, PsycINFO, APA PsycINFO, EBM Reviews, Scopus, and Web of Science for all available dates. Our primary outcomes of interest were patient-reported pain and anxiety scores using the Visual Analog Scale, the Brief Pain Inventory, the Depression Anxiety Stress Scale, the State-Trait Anxiety Inventory (STAI), and the Hospital Anxiety and Depression Scale (HADS). For the HADS and STAI scales, only the anxiety and anxiety-state subgroups were reported, respectively.
RESULTS: The literature search yielded 1746 articles. A total of 286 full-text articles were screened, and 16 studies were included in this systematic review. A total of eight studies assessed pain scores after invasive procedures; five reported improvements in pain scores, and three reported no change after meditative practices. Ten studies assessed anxiety outcomes after invasive procedures: nine reported a decrease in overall anxiety levels as a result of meditation practices while one study reported no change in anxiety scores.
CONCLUSION: Data from this limited literature suggests that different meditation practices could be effective in alleviating pain and anxiety within the perioperative phase for patients undergoing various types of invasive procedures. Future prospective studies are needed to determine whether routine meditation in the perioperative setting is effective in mitigating perioperative pain and anxiety.
PROBLEM TO BE SOLVED: To obtain an active oxygen scavenger having excellent active oxygen scavenging action and high ingestion efficiency to the body. SOLUTION: This agent contains a processed or extracted product of Camellia sinensis which is a native plant of the Kenya district of Eastern Africa and belonging to the tea of the family Camellia. The processed product can be produced by a rolling step to roll the leaf or stalk of Camellia sinensis and the fermentation step to ferment the rolled product. The extraction is carried out by extracting the leaf or stalk of Camellia sinensis with water. The processed or extracted product is used as an active oxygen scavenger and compounded by conventional method to obtain foods, bathing agents, cleansing compositions, etc. It is useful for the prevention and treatment of diseases caused by active oxygen, constipation, allergy, etc., and exhibits excellent effect on the prevention of aging, skin beautifying effect, body slimming effect, etc.
FIELD: microbiology. SUBSTANCE: method involves the treatment of antibiotic-resistant microorganisms with silver solution (2.5-5 mg/l) being successively or simultaneously with antibiotics. Silver solution is obtained by electrolytic method and brought about to isotonicity by sodium chloride addition. The following antibiotics were used: ampicillin, kanamycin, nalidixic acid (nevigramon), rifampicin, tetracycline, chloramphenicol. Invention ensures to decrease viability of cultures by 100 and 66 times at silver concentration 5 and 2.5 mg/l, respectively. EFFECT: increased sensitivity of antibiotic-resistant microbial strains to antibiotics. 2 tbl