anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This invention is related to a monitoring method of ST change events having time-relevant analysis and is adapted to monitor and recognize an inputted electrocardiogram of a subject. The method includes a monitoring model building step, a data collection building step, and a model training and testing step. The monitoring model building step includes using a deep learning technology capable of detecting a 10-second ST change event to build a monitoring model. The data collection building step includes building training collection data and testing collection data. The model training and testing step includes using the training collection data and the testing collection data built by the data collecting building step to subject the electrocardiogram of the subject to a training and testing operation. Accordingly, the method subjects the electrocardiogram to a signal-separation treatment, outputs a 10-second electrocardiogram signal by five time intervals for further selection of multi-time-step signals, extracts and classifies eigenvalues, and gets a classified result based on a category with higher probability, thereby monitoring and recognizing whether the subject electrocardiogram is a ST change event and efficiently increasing the accuracy of monitoring ST change events.
The invention provides a traditional Chinese medicinal composition for kidney tonifying. The traditional Chinese medicinal composition comprises Radix Asparagi, Radix Ophiopogonis, unprepared rehmannia root, prepared rehmannia root, wolfberry fruit, Ligustri Lucidi Fructus, Cortex Lycii, Polygonatum sibiricum, Semen plantaginis, cortex acanthopanacis, epimeddium, Eucommia ulmoides, Radix Morindae officinalis, Cistanche deserticola, semen cuscutae, Chinese angelica, Radix Astragali, ginseng, Fructus Rosae Laevigatae, Achyranthes bidentata, Radix Angelicae Pubescentis, Incised Notopterygium, Chinese yam, Acorus gramineus, Radix Polygalae, Smilax scobinicaulis C.H. Wright, Fructus Evodiae, raspberry, Chinese magnoliavine, platycladi seed and coix seed; and preferably, the traditional Chinese medicinal composition also comprises Aster tataricus L. f.. Weight part ranges and preferable weight part ranges of above medicinal materials are limited in the invention. The invention also provides a composition prepared from the traditional Chinese medicinal composition, and especially provides a health medicinal liquor and a preparation method thereof. The traditional Chinese medicinal composition, the composition and the health medicinal liquor can substantially treat or improve various symptoms induced by kidney essence deficiency, and improve the body quality and the life quality.
Our brains are constantly adapting to changes in our visual environments. Neural adaptation exerts a persistent influence on the activity of sensory neurons and our perceptual experience, however there is a lack of consensus regarding how adaptation is implemented in the visual system. One account describes fatigue-based mechanisms embedded within local networks of stimulus-selective neurons (networked fatigue models). Another depicts adaptation as a product of stimulus expectations (predictive coding models). In this review, I evaluate neuroimaging and psychophysical evidence that poses fundamental problems for predictive coding models of neural adaptation. Specifically, I discuss observations of distinct repetition and expectation effects, as well as incorrect predictions of repulsive adaptation aftereffects made by predictive coding accounts. Based on this evidence, I argue that networked fatigue models provide a more parsimonious account of adaptation effects in the visual system. Although stimulus expectations can be formed based on recent stimulation history, any consequences of these expectations are likely to co-occur (or interact) with effects of fatigue-based adaptation. I conclude by proposing novel, testable hypotheses relating to interactions between fatigue-based adaptation and other predictive processes, focusing on stimulus feature extrapolation phenomena.
An oil-in-water emulsion composition which gives a satisfactory use feeling, has excellent dispersion stability, and does not undergo surface roughening at the time of drying. A dispersion obtained beforehand by dispersing hydrophobized particles in an oil-phase ingredient and treating the mixture with a wet dispersing machine, e.g., a bead mill, is treated with a homomixer together with an aqueous phase to thereby obtain the oil-in-water emulsion composition. The composition is excellent in use feeling and particle dispersion after application to the skin. The dispersion stability of the particles is extremely heightened by using a specific dispersant in combination with a specific oil-phase ingredient. Incorporation of a salt-resistant thickener further improves the dispersion stability of the particles and can inhibit the composition from suffering sedimentation of emulsified particles or creaming with time. Use of succinoglycan as the thickener eliminates a tacky feeling. By plasticizing the succinoglycan, the surface roughening is eliminated.
Group of patients of any age, any sex, that will receive a complete scheme of approved mRNA-1273 vaccination, assigned by a local government vaccination campaign. It can also include patients that receive a third or fourth boost.
The curriculum provides comprehensive sexual education on topics such as anatomy, puberty, sexually transmitted infections, and contraceptive methods (including abstinence). It also covers topics such as gender and sex roles, sexual orientation, decision making and conflict resolution, adult-teen relationships, rape and sexual assault, and coping with stress. The curriculum can be delivered in different formats that range in length from 6 to 12 weeks.
Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes, but its pathogenesis has not been clearly elucidated. Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression. Therefore, in the present study, we analysed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance throughout the three trimesters. We found that the variation trends of 38 metabolites were significantly changed during GDM development. Specifically, longitudinal analyses revealed that cysteine (Cys) levels significantly decreased over the course of GDM progression. Further study showed that Cys alleviated GDM in female mice at gestational day 14.5, possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis. Taken together, these findings suggest that the Cys metabolism pathway might play a crucial role in GDM and Cys supplementation represents a potential new treatment strategy for GDM patients.
Osteoarthritis involves a wearing down of the cartilage within a joint. It can affect any joint in the body, but it most commonly affects joints in the hands, hips, knees, and spine. Over the last few years, a new medicine called hyaluronan has been used for treating osteoarthritis. Hyaluronan is a man-made preparation of a protein complex that occurs naturally in joints and that is often low in people with osteoarthritis. Although hyaluronan has been used in millions of people with knee osteoarthritis, it is not yet FDA approved for use in the thumb. The purpose of this study is to determine the safety and effectiveness of hyaluronan in relieving arthritis symptoms at the base of the thumb and to compare it to corticosteroids and local anesthetic. Specifically, the study will evaluate pain relief, patient satisfaction, and functional outcomes among participants.

Participation in this study will last 26 weeks. Screening will include a questionnaire and an x-ray of the affected thumb. Eligible participants will then be randomly assigned to one of three treatments: two hyaluronan injections, one corticosteroid injection plus one local anesthetic injection, or two local anesthetic injections. Participants will receive the injections at the base of their thumb, and the first injection will be followed by the second injection a week later. There will be five study visits that will occur at baseline and Weeks 2, 4, 12, and 26. All study visits will include questionnaires, and except for the Week 2 study visit, they will also include an examination and evaluation of the affected thumb. Photographs of the thumb will be taken at baseline. The injections will occur at baseline and Week 2. At Weeks 8 and 20, questionnaires will be mailed to participants for them to complete. Upon completing the study, participants will have the option of receiving continued treatment with another round of hyaluronic injections.
This is a double-blinded, prospective, randomized, study in eighty-six subjects with clinical ASCVD with PAD on background treatment with maximal tolerated dose of a statin. Subjects will be assessed based on their medical history and physical examination. Eligible subjects must meet all inclusion criteria and none of the exclusion criteria (listed below). There will be a treatment group and a placebo group, each with equal number of participants (n=43 patients in each group). After consent and enrollment, subjects will have a venous blood sample drawn to perform serum circulating biomarkers of oxidative stress as oxidized low density lipoprotein (oxLDL), oxidized glutathione : reduced glutathione (GSH:GSSG) and soluble CD36 (sCD36). We will then perform: functional walking measurements, pain free walking time (PFWT), and (maximal walking time (MWT), lower extremity arterial perfusion assessment (rest ABI/TBI, post-exercise ABI and bilateral TcPO2), and brachial endothelial function testing (after hyperemia). Subjects will receive monthly subcutaneous injections of Evolocumab 420 mg or placebo injection. The study participants will be seen at three months and six months for follow up and a final assessment at 26 +/-2 weeks, all tests will be repeated for comparison from baseline and/or placebo.
Community college students are an underserved and at-risk population in terms of their sexual and relationship health. One promising avenue for improving sexual decision making among this population is media literacy education (MLE). Though studies show MLE is an effective approach to sexual health promotion there is a need to better understand the mechanisms by which MLE programs impact health outcomes. The ultimate goals of this study are to 1) advance theoretical frameworks of media literacy to better understand the underlying mechanisms that lead to sexual health behavior change and 2) enhance the sexual and relationship health of community college students by identifying successful methods of health promotion and strategies to implement health programs at community colleges. This study is a three-arm randomized control trial (RCT) with 2010 community college students (ages 18-19) from 30 colleges across the U.S. All components of this study (i.e., interventions, surveys) are web-based.

Participating students will be randomized to one of three conditions: 1) students who receive a sexual health program grounded in MLE (Media Aware); 2) students who receive a sexual health program with no MLE; and 3) a wait-list control group. Participants will complete pretest, posttest, 6-month follow-up, and 12-month follow-up surveys to examine changes across the three groups in our primary outcomes (e.g., risky sexual behavior) and secondary outcomes (e.g., sexual health knowledge, rape myth acceptance, perceived realism of media messages).
BACKGROUND: Tetralogy of Fallot is a congenital heart disease mostly diagnosed and treated in early childhood. However, there are some adult cases receiving treatment.
CASE PRESENTATION: We describe a 78-year-old Japanese woman who presented with severely hypertrophic right ventricle, ventricular septum defect, overriding aorta, and severe infundibular stenosis in the right ventricular outflow tract. As hypoxemia was mild and daily exertion was sufficiently possible, home oxygen therapy was introduced. After 1 month, she was referred because of a positive blood culture. The blood culture test was positive four times, therefore, the antibacterial drug was administered according to active infective endocarditis. SpO2 repeatedly decreased during hospitalization, thus oxygen was needed. As there were infective endocarditis onset and progressive hypoxemia, we planned a surgical correction.
CONCLUSION: Tetralogy of Fallot was diagnosed and successfully treated with complete surgical correction, and the development of infective endocarditis was the definitive indication for surgery at this late age.
Formulations for oral transmucosal compositions including a synergistic combination of low doses of testosterone with an aromatase inhibitor (AI) that are combined with transmucosal absorption enhancers are disclosed. Oral transmucosal compositions can be for fast release or slow release, and can be administered to increase bloodstream testosterone levels and thereby reduce symptoms of testosterone deficiency. Oral transmucosal compositions include liquid dosage forms, solid dosage forms, and chewing gums. Further dosage forms include mucoadhesive thin strips, thin films, tablets, patches, and tapes, among others. Other dosage forms are: mucoadhesive liquids such as gel-forming liquids; gel-forming semisolids; and gel-forming powders, among other dosage forms that exhibit mucoadhesive properties, and provide oral transmucosal delivery of testosterone and AI. Oral transmucosal compositions will deliver testosterone and AI directly into the patient's bloodstream, and provide high bioavailability of testosterone and AI; therefore, the required doses are lower.
Geriatric – Population pharmacokinetic studies conducted with oxycodone hydrochloride tablets, indicated that the plasma concentrations of oxycodone did not appear to be increased in patients over the age of 65.

Gender – Population pharmacokinetic analyses performed in the clinical study support the lack of gender effect on the pharmacokinetics of oxycodone from oxycodone hydrochloride tablets.

Race – Population pharmacokinetic analyses support the lack of race effect on oxycodone pharmacokinetics after administration of oxycodone hydrochloride tablets, but these data should be interpreted conservatively, since the majority of patients enrolled into the studies were Caucasians (94%).

Renal Insufficiency – In a clinical trial supporting the development of oxycodone hydrochloride tablets, too few patients with decreased renal function were evaluated to study these potential differences. In previous studies, patients with renal impairment (defined as a creatinine clearance < 60 mL/min) had concentrations of oxycodone in the plasma that were higher than in subjects with normal renal function. Based on information available on the metabolism and excretion of oxycodone, dose initiation in patients with renal impairment should follow a conservative approach. Dosages should be adjusted according to the clinical situation.

Hepatic Failure – In a clinical trial supporting the development of oxycodone hydrochloride tablets, too few patients with decreased hepatic function were evaluated to study these potential differences. However, since oxycodone is extensively metabolized, its clearance may decrease in hepatic failure patients. Dose initiation in patients with hepatic impairment should follow a conservative approach. Dosages should be adjusted according to the clinical situation.
A prospective, randomized, double-blinded, placebo-controlled study was conducted. One hundred and twenty-four patients were allocated to receive 2 dosages of either 45 ml of sodium phosphate plus 240 mg of simethicone tablets or 45 ml of sodium phosphate plus placebo in the evening before and in the morning of the procedure day. The colonoscopic examination was recorded. Visibility was blindly assessed for the amount of air bubbles and the degree of haziness by a single investigator. Five areas of the colon were graded for the amount of air bubbles, from 0 to 3; grade 0 and 1 were defined as the diminishing of air bubbles. The haziness was graded into 5 levels from excellent to unacceptable. Excellent, good and adequate were defined as the diminishing of haziness. The total duration of colonoscopy, the side effect of medication and the endoscopist and patient satisfaction were compared between 2 groups. Endoscopist satisfaction was evaluated by questionnaires. Visual analog scale (0-10) was used for rating patient satisfaction and the side effect of medication.
This invention discloses a temperature-sensitive chitosan/polyvinyl alcohol gel and its preparation method. The chitosan/polyvinyl alcohol gel is a physical mixed gel and its effective components include chitosan and polyvinyl alcohol. The gel formation time is different according the different ratio of chitosan and polyvinyl alcohol. The preparation method is: dissolve the chitosan into hydrochloric acid completely within ice-bath, put the sodium acid carbonate into polyvinyl alcohol and then put the solution in ice-bath. Keep stirring and within ice-bath, the solution of sodium acid carbonate polyvinyl alcohol drops slowly into chitosan hydrochloric acid solution and make sure that there is no residue in the solution. After removing bubble by centrifugation, the gel was obtained. This temperature-sensitive gel is liquid stage when the temperature is low, and the gel can be formed at the body temperature. So the gel can be injected into material. The preparation method in this invention is technical security, simple and effective. The gel is fit to carry the sensitive medicament and the slow-release effect is good.
A Chinese herbal medicine treating crucian sporozoosis is disclosed. The technical scheme comprises the medicine and a usage method. The medicine comprises artemisinin and a composition Baochongbike II named by the inventor. The usage method comprises blending 100 mL of artemisinin into 40 Kg of a forage, using the mixture for continuous 5 days, externally using Baochongbike II at the third day, the usage amount is 100 mL/mu, and spreading to a whole pool after being diluted with water. The Chinese herbal medicine has the characteristics of no toxin, no side effect, no residue, no easiness of generating drug resistance, no pollution to environment and the like, and is used to prevent and treat crucian sporozoosis with substantial treatment effect. The method is simple, operation is convenient, cure rate is high, healing is fast, the medicine is cheap, and the treatment cost is low.
PURPOSE: The overwhelming inflammatory response plays a critical role in the secondary injury cascade of traumatic spinal cord injury (tSCI). The systemic immune inflammatory index (SII) and systemic inflammatory response index (SIRI) are two novel inflammatory biomarkers. The SII was calculated based on lymphocyte, neutrophil, and platelet counts, while the SIRI was calculated based on lymphocyte, neutrophil, and monocyte counts. Their prognostic value in patients with tSCI remains unclear.
METHODS: Patients with tSCI admitted within 24 h of trauma were retrospectively and consecutively enrolled. Peripheral blood samples were collected on admission. The primary outcome was American Spinal Injury Association Impairment Scale (AIS) grade conversion at discharge. Multivariable logistic regression analysis was performed to determine the relationship between SII and SIRI and AIS grade conversion. We performed receiver operating characteristic curve (ROC) analysis to assess the discriminative ability of SII, and SIRI in predicting AIS grade conversion.
RESULTS: Among 280 included patients, 77 (27.5%) had improved AIS grade conversion at discharge. After adjustment for confounders, SII was independently associated with AIS grade conversion (per SD, odds ratio [OR], 0.68; 95% confidence interval [CI] 0.47-0.98, p = 0.040), while the association between SIRI and AIS grade conversion was insignificant (per 1 SD, OR, 0.77; 95% CI 0.55-1.08, p = 0.130). The ROC analysis revealed that the SII had the best predictive value for AIS grade conversion (area under curve: 0.608, 95% CI 0.536-0.678).
CONCLUSIONS: Increased SII was independently associated with a decreased likelihood of improved AIS grade conversion.
FIELD: medicine. SUBSTANCE: method involves administering low-calorie diet, physical training exercises and self- massage. Alternating subcutaneous injections of ozone-oxygen mixture are administered to zones injured with edematous fibrosclerous panniculopathy and intravenous ozonized physiological salt solution injections. Ozone concentration in the gas mixture is equal to 1.0-3.0 mg/l. Ozone concentration in the physiological salt solution is equal to 1.5-2.0 mg/l. The treatment is administered in 2-6 courses with 3-4 moths long pauses. Each course has 5-10 subcutaneous injections with 4-8 intravenous dropping infusions. EFFECT: enhanced effectiveness of treatment; improved lipogenesis, lipolysis oxygen supply of tissues. 4 tbl
Case management is being implemented as a health service strategy that should contribute to maximize health outcomes within a cost-constrained environment. Evaluations of case management in Danish settings are sparse, and so far no Danish studies have evaluated the cost-effectiveness of case management.

This study is performed as a RCT, and the study focuses exclusively on patients with COPD. The patients will be enrolled and randomized after being referred to rehabilitation at the local rehabilitation center in Aalborg municipality, Denmark. 150 patients will be randomly assigned to two groups of 75 patients each. Participants in the control group will receive usual care, whereas patients assigned to the interventional group will receive case management besides their usual care. Each patient will be followed for 12 months. Patients in both groups will fill out questionnaires at baseline and 12 months. The data register system "Health - Planning and Quality" in the Northern Region of Jutland will be used to determine health care services and costs.
The data described below reflect exposure to Imiquimod Cream or vehicle in 436 subjects enrolled in two double-blind, vehicle-controlled studies. Subjects applied Imiquimod Cream or vehicle to a 25 cm2 contiguous treatment area on the face or scalp 2 times per week for 16 weeks.

Local skin reactions were collected independently of the adverse reaction "application site reaction" in an effort to provide a better picture of the specific types of local reactions that might be seen. The most frequently reported local skin reactions were erythema, flaking/scaling/dryness, and scabbing/crusting. The prevalence and severity of local skin reactions that occurred during controlled studies are shown in the following table.

The adverse reactions that most frequently resulted in clinical intervention (e.g., rest periods, withdrawal from study) were local skin and application site reactions. Overall, in the clinical studies, 2% (5/215) of subjects discontinued for local skin/application site reactions. Of the 215 subjects treated, 35 subjects (16%) on Imiquimod Cream and 3 of 220 subjects (1%) on vehicle cream had at least one rest period. Of these Imiquimod Cream subjects, 32 (91%) resumed therapy after a rest period.

In the AK studies, 22 of 678 (3.2%) of Imiquimod-treated subjects developed treatment site infections that required a rest period off Imiquimod Cream and were treated with antibiotics (19 with oral and 3 with topical).

Of the 206 Imiquimod subjects with both baseline and 8-week post-treatment scarring assessments, 6 (2.9%) had a greater degree of scarring scores at 8-weeks post-treatment than at baseline.