anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Dental floss incorporates a dental medicament and a water-soluble binder which will adhere to the teeth and slowly liberate the medicament as it dissolves in the saliva. Medicaments are those which neutralise, sequester, buffer or counteract acids in the interproximal regions, e.g. zinc chloride and potassium ferrocyanide, which react to form an insoluble protective coating of zinc ferrocyanide, aliphatic amines, e.g. tricetylamine, cyclic amines, e.g. hexamethylene tetramine, fatty acid amides containing less than 25 C atoms, e.g. stearamide, basic amino acids, e.g. lysine, polypeptides, e.g. glycyl glycine, inorganic basic salts, e.g. (NH4)2CO3, <FORM:0680250/VI/1> compounds which give rise to basic products, e.g. urea or buiret, the specific mixture of urea with dibasic ammonium phosphate, or cellulosic ether amides; the medicament or mixtures thereof may be used up to 20 per cent by weight of the floss.  Binders are gums, resins, waxes and cellulose derivatives, e.g. solid ethylene glycol polymer (carbowax), methyl cellulose, sodium carboxymethyl cellulose, glue, gelatin, Tragacanth, Gum Arabic, or algin.  The floss may be linen, silk, cotton, "Vinyon" (R.T.M.), nylon, or mixtures thereof, and the yarns may be braided, spun, thrown, or fused, with or without twist; paper tapes or fibre backed paper tapes or catgut may also be used.  The floss may be impregnated by passing it through a bath containing the binder, molten or dissolved in water, and one or more medicaments, or the medicament may be applied by dusting it on a yarn impregnated with a binder which is tacky enough to provide adhesion.
Loss of hand function is common after stroke. Previous research suggests that treatments that focus on movement of both hands at the same time or treatments that electrically stimulate the paretic (weak) hand muscles may help the recovery of hand function after stroke. In this study, two electrical stimulation treatments will be compared in their effectiveness in restoring hand movement and hand function. One of the treatments is stimulation only, and the other is stimulation linked to movement of the contralateral hand.

Study participants will be stroke survivors who are enrolled while they are still within their first 6 months after their stroke. After enrolling, their hand movement and function will be tested. Then they will be randomly assigned to one of the two treatments. Each treatment will last 6 weeks. The treatment will require the participant to perform specific exercises at home for a total of 2 hours every day and to come to the laboratory twice a week for study-related occupational therapy. At the end of the 6-week treatment, tests of hand movement and hand function will be repeated. The same tests will be repeated again at 1 and 3 months after the end of treatment to see if the effects of the treatment persist as time goes on. Changes in upper extremity impairment and activity limitation will be compared across treatment groups.
FIELD: organic chemistry. SUBSTANCE: product: 4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene carboxylic acid arylalkyl esters that were synthesized from 4,5-diacetooxy-9,10-dihydro-9,10-dioxo-2-anthracene carboxylic acid chloroanhydride by treatment with alcohol of the formula RCH 2 OH where: R - CH 2 O - alcohol residue RCH 2 OH, followed by treatment with weak alkali solution. Pharmcomposition contains this agent at amount 5-500 mg per a single dose. Synthesized compound is used in medicine. EFFECT: improved method of synthesis. 6 cl
INTRODUCTION: Subarachnoid hemorrhage (SAH) is a critical medical condition associated with high morbidity and mortality rates. Timely and accurate diagnosis is crucial for optimal patient outcomes. Cranial computed tomography (CT), computed tomography angiography (CTA), and digital subtraction angiography (DSA) are commonly used imaging modalities for diagnosing SAH, but their comparative diagnostic efficacy remains debated.
METHODS: A systematic review and meta-analysis was conducted to evaluate the diagnostic performance of cranial CT, CTA, and DSA in identifying SAH. PubMed, Google scholar, Cochrane Library databases were searched for relevant studies published up to January 2024. Pooled sensitivity, specificity, and the summary receiver operating characteristic (SROC) curve were calculated using Review Manager 5.4.
RESULTS: A total of 31 studies involving 10,287 patients were included in the analysis. The pooled sensitivity of cranial CT for detecting SAH was 94.7 % (95 % Confidence Interval, CI) with a specificity of 98.3 % (95 % CI). CTA demonstrated a pooled sensitivity of 94.1 % (95 % CI) and specificity of 93.4 % (95 % CI). DSA showed a pooled sensitivity of 87.7 % (95 % CI) and specificity of 95.8 % (95 % CI). The SROC curve demonstrated discriminatory ability for all modalities.
CONCLUSION: Cranial CT, CTA, and DSA are valuable imaging modalities for diagnosing SAH, with high sensitivity and specificity. Cranial CT serves as an initial screening tool, while CTA offers superior sensitivity in detecting aneurysmal SAH. DSA remains essential in specific clinical scenarios. Further prospective studies are needed to validate these findings and refine diagnostic guidelines for SAH.
Participants will be randomly selected by a computer based system (Block randomization was used to keep the sample size of the groups similar. Random Allocation Software (Ver. 1.0.0) will be used to allocate the patients to groups). Selected participants will be invited to a meeting which will be held face-to-face and in a quiet environment. Progressive Relaxation Exercises will be explained to this group in a step-by-step manner whose surgery date is determined to undergo bariatric surgery by the relevant researcher. After this stage, participants will be followed to do the exercises regularly for a month by a researcher. Patients will fill the Amsterdam Preoperative Anxiety and Information Score Scale preoperatively at the hospital. After the surgery, the patients will be evaluated by the researchers in terms of pain scores and analgesic usage frequency in the recovery room and 1st, 4th, 8th, 12th, 24th, 36th and 48th hours data will be collected in the postoperative service.
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes derivatives of piperazine of the general formula (I)   where A means alkylene chain comprising from 2 to 4 carbon atoms optionally substituted with lower alkyl; Z means oxygen or sulfur atom; R means hydrogen atom or lower alkyl; R 1  means unsubstituted phenyl or phenyl mono- or disubstituted with lower alkyl, halide, hydroxy- or lower alkoxy-group; unsubstituted naphthyl of naphthyl substituted with lower alkoxy-group; tetrahydro-naphthyl, isoquinolinyl, indolyl, bicyclic radical of the formula a)   or b)  ; R 2  means monocyclic aromatic heterocyclic 6-membered ring comprising one N atom as heteroatom or it means bicyclic aromatic heterocyclic ring system comprising one such 6- membered monocyclic aromatic heterocyclic ring condensed with benzene ring under condition that indicated bicyclic heterocyclic radical is joined with nitrogen of amine of the formula (I) through carbon atom of heterocyclic ring, or R 2  means thiazolyl; and R 3  means lower alkyl, lower cycloalkyl, lower cycloalkenyl, phenyl, cyanophenyl or group of the formula -NR 4 R 5  where R 4  means hydrogen atom and R 5  means lower cycloalkyl, adamantyl or R 4  and R 5  in common with nitrogen atom to which they both are joined form piperidino-radical. Invention relates also to method of their synthesis, pharmaceutical composition and intermediate compound, namely 1-(2-methoxyphenyl)-4-[2-(2- pyridinylamino)ethyl] piperazine. New compounds show favorable action on central nervous system by means their ability to bind with 5-HT-receptors. EFFECT: improved method of synthesis, valuable medicinal properties. 10 cl, 71 ex
The magnitude of bowel dysfunction in spinal cord injury patients has been documented in several studies. Spinal cord injury affects colorectal motility, transit times, and bowel emptying often leading to constipation, fecal incontinence or a combination of both. Although these symptoms are not life-threatening, they may have a severe impact on quality of life as well as increase levels of anxiety and depression.

Various bowel management programs have been empirical, and individual solutions have been sought on a trial-and-error basis. Transanal irrigation has been used in selected patients with constipation or fecal incontinence. The majority of spinal cord injured patients in a recent study benefited from the treatment. However, there is limited evidence in the literature supporting any bowel management program in spinal cord injury in favor of another and well-designed controlled trials are still lacking. Therefore, the present study aims to compare transanal irrigation with conservative bowel management, defined as best supportive bowel care without irrigation, in a prospective, randomized, controlled, multicentre study among spinal cord injured patients with neurogenic bowel dysfunction.
Genetic variants associated with increased liver fat and volume have been reported, but whether physical activity (PA) can attenuate the impact of genetic susceptibility to these traits is poorly understood. We aimed to investigate whether higher PA modify genetic impact on liver-related traits in the UK Biobank cohort. PA was self-reported, while magnetic resonance images were used to estimate liver fat (n = 27,243) and liver volume (n = 24,752). Metabolic dysfunction-associated liver disease (MASLD) and chronic liver disease (CLD) were diagnosed using ICD-9 and ICD-10 codes. Ten liver fat and eleven liver volume-associated genetic variants were selected and unweighted genetic-risk scores for liver fat (GRSLF) and liver volume (GRSLV) were computed. Linear regression analyses were performed to explore interactions between GRSLF/ GRSLV and PA in relation to liver-related traits. Association between GRSLF and liver fat was not different among lower (β = 0.063, 95% CI 0.041-0.084) versus higher PA individuals (β = 0.065, 95% CI 0.054-0.077, pinteraction = 0.62). The association between the GRSLV and liver volume was not different across different PA groups (pinteraction = 0.71). Similarly, PA did not modify the effect of GRSLF and GRSLV on MASLD or CLD. Our findings show that physical activity and genetic susceptibility to liver-related phenotypes seem to act independently, benefiting all individuals regardless of genetic risk.
The long-term effects of ORLISTAT on morbidity and mortality associated with obesity have not been established.

The effects of ORLISTAT on weight loss, weight maintenance, and weight regain and on a number of comorbidities (e.g., type 2 diabetes, lipids, blood pressure) were assessed in the 4-year XENDOS study and in seven long-term (1- to 2-years duration) multicenter, double-blind, placebo-controlled clinical trials. During the first year of therapy, the studies of 2-year duration assessed weight loss and weight maintenance. During the second year of therapy, some studies assessed continued weight loss and weight maintenance and others assessed the effect of ORLISTAT on weight regain. These studies included over 2800 patients treated with ORLISTAT and 1400 patients treated with placebo (age range 17-78 years, 80.2% women, 91.0% Caucasians, 5.7% Blacks, 2.3% Hispanics, 0.9% Other). The majority of these patients had obesity-related risk factors and comorbidities. In the XENDOS study, which included 3304 patients (age range 30-58 years, 55% women, 99% Caucasians, 1% other), the time to onset of type 2 diabetes was assessed in addition to weight management. In all these studies, treatment with ORLISTAT and placebo designates treatment with ORLISTAT plus diet and placebo plus diet, respectively.

During the weight loss and weight maintenance period, a well-balanced, reduced-calorie diet that was intended to result in an approximate 20% decrease in caloric intake and provide 30% of calories from fat was recommended to all patients. In addition, all patients were offered nutritional counseling.
Although the pattern of adverse events in this study seems somewhat different from that seen in patients with partial seizures, this is likely due to the much smaller number of patients in this study compared to partial seizure studies. The adverse event pattern for patients with PGTC seizures is expected to be essentially the same as for patients with partial seizures.

In the well-controlled clinical study that included patients 4 years of age and older with primary generalized tonic-clonic (PGTC) seizures, the most frequently reported adverse event associated with the use of KEPPRA in combination with other AEDs, not seen at an equivalent frequency among placebo-treated patients, was nasopharyngitis. 

Table 11 lists treatment-emergent adverse events that occurred in at least 5% of idiopathic generalized epilepsy patients experiencing PGTC seizures treated with KEPPRA and were numerically more common than in patients treated with placebo. In this study, either KEPPRA or placebo was added to concurrent AED therapy. Adverse events were usually mild to moderate in intensity. 

Other events occurring in at least 5% of KEPPRA-treated patients with PGTC seizures but as or more frequent in the placebo group were the following: dizziness, headache, influenza, and somnolence.
In Arm 2, we will evaluate whether smaller, rather than larger, decreases in the availability of alternative reinforcement decreases the magnitude of resurgence. Investigators will counterbalance the order of differently sized decreases in alternative reinforcement with half of the participants in Arm 2 to determine whether the order of such decreases also affects resurgence magnitude.
Determination of energy requirements for growth depends on measuring the composition of BW gain. Previous studies have shown that the composition of gain can be altered in young dairy calves by the composition of the milk replacer diet. Here, our objective was to determine body composition and the composition of empty body gain in young calves fed increasing amounts of a milk replacer containing adequate CP. Male Holstein calves underwent an adjustment period of 14 d after birth in which they were fed whole-waste milk at 10% of BW. Calves were then stratified by BW and randomly assigned to either an initial slaughter group (n = 11) or to groups fed 1 of 3 milk replacer amounts and slaughtered after 35 d of growth. Calves in all treatments consumed the same milk replacer containing 24.8% CP (DM basis; from all milk proteins) and 18.9% fat, reconstituted to 12.5% solids. Treatments were milk replacer fed at 1.25% of BW (DM basis; n = 6), 1.75% of BW (n = 6), or 2.25% of BW (n = 8), adjusted weekly as calves grew. Calves fed at 1.25% or 1.75% of BW were fed twice daily and those fed 2.25% of BW were fed 3 times daily. No starter was offered. Postslaughter, the bodies of calves were separated into 4 fractions: carcass; total viscera minus digesta; head, hide, feet, and tail;, and blood. The sum of those 4 fractions was empty BW (EBW), which increased linearly as the amount of milk replacer increased. Final heart girth and body length, but not withers height, increased linearly as intake increased. Gain:feed increased linearly with increasing milk replacer. Feeding more milk replacer increased the amounts of lean tissue and fat in the body. The percentages of water and protein in the final body decreased linearly, whereas fat percentage and energy content increased linearly as intake increased. As gain increased, the percentage of protein in gain decreased and the percentage of fat increased, resulting in an increase of energy content of EBW gain. Efficiency of energy use (retained energy:gross energy intake) increased linearly but retained energy:ME available for growth was not different among treatments. Efficiency of protein use increased quadratically as feeding rate increased; there was no further increase at 2.25% of BW. Plasma insulin-like growth factor 1, insulin, and glucose increased linearly, whereas urea-N decreased linearly, as milk replacer intake increased. Our data document changes in body composition that affect estimates of retained energy in the bodies of calves slaughtered at a common age. These data are important for calculations of energy requirements for young calves.
This study is only for members of the Group Health Cooperative (GHC) of Puget Sound who have both osteoarthritis pain and insomnia. The first part of the study involves filling out a mailed survey. Based on the results of the survey some respondents will be eligible for the second part of the study. Our goal in the second part is to test three different treatments for managing OA symptoms. The programs teach about things people with arthritis can do to improve the quality of their lives. All three programs deal with pain, sleep, mood and activity-but each has a slightly different focus. Participants will be randomly assigned to one of the three programs. Each program is made up of six weekly group sessions that last about 90-120 minutes. The programs will be co-led by licensed therapists and each will include 8-12 members. Study participants will also take part in a series of visits at their homes over the next 18 months. At each visit the investigators will ask them to do a few other study activities, such as keep a 7-day diary of their sleep and fill out a survey about their arthritis pain. With their permission the investigators will also ask them to let us collect some information from their GHC medical records.
Tobacco use remains the number one cause of premature death and morbidity in the United States, and tobacco-related diseases account for 24% of all VA healthcare costs. The VA has been a leader in addressing tobacco use, having implemented annual tobacco screening and made pharmacotherapy readily available. However, one of the most cost-effective services - telephone quit lines - remain highly underused. Few Veterans enroll in telephone counseling to help them quit smoking, and among Veterans who begin telephone counseling, few complete a full course. The advent of electronic health records (EHRs) has enabled new strategies for ensuring that patients receive preventive services. These methods can reduce provider burden and close gaps in systems of care. The investigators' research team has conducted numerous studies using EHRs to identify smokers and proactively reach out to coordinate telephone tobacco treatment. While the investigators have successfully implemented this approach, the overall enrollment rates for counseling remain low and the majority of smokers complete only one counseling session. Therefore, the investigators propose to test novel mHealth strategies for promoting enrollment in and adherence to telephone counseling. The Specific Aims are to: 1) Conduct a sequentially randomized trail to estimate the effectiveness of text messaging for increasing enrollment in and adherence to telephone tobacco treatment, 2) Compare rates of tobacco cessation between patients who received and did not receive text messaging during treatment, and 3) Evaluate patient experiences with these interventions. Using the VA EHR, the investigators will identify N=3,600 smokers at two VA sites. All identified smokers will be mailed an introductory packet with information about the study. Patients who consent will be randomized to standard telephone outreach for counseling or to receive 8 educational texts to counter barriers of participating in counseling prior to telephone outreach. Patients who enroll in tobacco treatment will then be randomized to receive standard telephone counseling or to also receive appointment reminders and supportive texts throughout the 8-week counseling period. The investigators hypothesize that these approaches will increase the rate of enrollment in telephone tobacco cessation and 12-month biochemically validated abstinence (primary outcomes) over standard telephone counseling approaches. The investigators will also assess patient experiences with each texting protocol. The investigators' overarching goal is to investigative innovative mHealth strategies for increasing Veteran use of telephone-based tobacco cessation counseling and to improve quit rates. This research, exploring both population-based outreach and text messaging, advances multiple goals set forth by the VA's Blueprint for Excellence. Results will have direct implications to inform decision-making and population-based care models for tobacco treatment.
Disclosed are protocols, isolation means, and compositions of matter useful for identifying mesenchymal stem cells possessing enhanced clinical activity. In one embodiment, markers associated with said enhanced mesenchymal stem cell activity are utilized to identify donors whose mesenchymal stem cells possess superior efficacy compared to mesenchymal stem cells from donors who lack said markers associated with said enhanced efficacy. In one embodiment, said markers are utilized to select for mesenchymal stem cells possessing enhanced efficacy from in vitro cultures. In another embodiment, surfaces markers associated with said markers associated with enhanced efficacy are utilized to positively select for cells possessing enhanced efficacy. In another embodiment, the invention teaches markers whose expression is correlated with negative efficacy. Said markers can be utilized to exclude mesenchymal stem cell donors, or in vitro generated and/or isolated mesenchymal stem cells prior to clinical use. In another embodiment the invention teaches a method of augmenting mesenchymal stem cell efficacy by inhibiting the expression of proteins found in higher concentrations in cells without enhanced clinical activity. Additionally, novel mesenchymal stem cells phenotypes are disclosed possessing enhanced efficacy compared to existing mesenchymal stem cells based on unique phenotypic characteristics.
ABSTRACT A system and method for increasing patient adherence to following medication treatment regimens. An adherence data processing and communication system generates and displays medication adherence data based on historical medication information. The system is linked to other systems involved with electronic ordering and filling of prescriptions, such as electronic prescription and pharmacy systems all connected by suitable wired and/or wireless communication protocols including the Internet. In one embodiment, the adherence data is displayed in the form of an interactive report card which provides a user with adherence metrics in both summary and more detailed formats for prescription medications taken by the patient. A related method executed by the data processing and communication system is disclosed. Date Recue/Date Received 2021-04-16
NEW MATERIAL:An antibiotic SUM-3 of formula and its non-toxic acid addition salt. USE:Antibacterials having a powerful antibacterial action against Gram-positive and Gram-negative bacteria, and bacteria of the genuses Proteus and Pseudomonus, and Escherichia coli resistant to the well-known antibiotics. Useful as cleaning agents for laboratory glasswave and apparatuses. PROCESS:autibiotic sum-3 producing strains which belong to the genus Micromonospora are cultured in a nutrient medium to produce and accumulate the antibiotic SUM-3, and the title substance is obtained from the cultured product. Micromonos pora sagamiensis SU-2 (FERM-P No. 4230) (NRRL-11182), etc. may be cited as the microorganism to produce the antibiotic SUM-3.