anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a method for preparing medicinal liquor. The method comprises a component ratio, a production and a using method. 1. The component ratio: 480g of tuber fleece-flower roots, 40g of Chinese angelica, 20g of Chinese wolfberry fruits, 50g of lotus seeds, 30g of gingers, 40g of honey, 15g of asparagus roots, 2kg of fragrant round rice, 15 red dates, and 2g of large-headed atractylodes rhizomes; 2. the production method comprises the following steps: (1). the tuber fleece-flower roots are boiled with water and smashed, and the gingers are juiced for standby; (2). the Chinese angelica, the Chinese wolfberry fruits, the lotus seeds, the asparagus roots, and the red dates are smashed into crude powder, and the crude powder and the tuber fleece-flower roots are sealed in a cloth bag for standby; (3). 2100ml of water is added into the fragrant round rice, and the rice is boiled into congee state with slow fire and stored in a jar; (4). after the congee is cooled, the ginger juice is added with uniform stirring, and the congee is sealed; (5). fine powder of the large-headed atractylodes rhizomes is placed into vinasse with uniform stirring, and the vinasse is sealed for 4-6 days and opened; (6). vinasse dregs are removed, the wine is placed in a jar, and the cloth bag is placed into the wine; (7). the wine jar is heated with water bath for 1.5 hours and is imbedded in soil; (8). after 5 days, the wine is taken out, the cloth bag is removed, and the honey is poured into the wine; 3. the drinking method is as follows: the wine is warmed, 15-20ml of wine can be drunk one time for empty stomach, and the wine is drunk twice a day.
This is a proposed double-blind, crossover study that enrolls young adult smokers who prefer menthol cigarettes. The study will consist of an adaptation session and three test sessions. In the adaptation session, participants will practice using the e-cigarette by sampling the flavors to be used in the test sessions. The test sessions will be performed following overnight abstinence from tobacco. Across the three test sessions, participants will be assigned to a random sequence of the three different e-cigarette conditions: menthol, green apple or menthol plus green apple, a different flavor condition for each test session. In each test session, just after the assigned flavor is delivered via the e-cigarette, participants will receive a random order of one intravenous delivery of saline, and two intravenous deliveries of nicotine (3.6 mcg/kg and 7 mcg/kg or 0.25 mg/70 kg and 0.5 mg/70kg), one hour apart. The test sessions will be performed at least 24 hours apart to minimize carryover nicotine effects. The main outcome measure will be subjective drug effects as measured with the Drug Effects Questionnaire (DEQ). Other outcomes include cardiovascular measures, cognitive performance, and self-report measures of nicotine withdrawal and craving. Cardiovascular measures include heart rate, systolic and diastolic blood pressure. Cognitive performance will be assessed with the Stroop test, mathematical processing test (MPT), and continuous performance test (CPT). Nicotine withdrawal measures will be measured with the Minnesota Nicotine Withdrawal Symptom Checklist (M-NWSC) and the Brief Questionnaire on Smoking Urges (BQSU).
UNLABELLED: Chronic obstructive pulmonary disease (COPD) is one of the primary causes of mortality and morbidity worldwide. The gut microbiome, particularly the bacteriome, has been demonstrated to contribute to the progression of COPD. However, the influence of gut virome on the pathogenesis of COPD is rarely studied. Recent advances in viral metagenomics have enabled the rapid discovery of its remarkable role in COPD. In this study, deep metagenomics sequencing of fecal virus-like particles and bacterial 16S rRNA sequencing was performed on 92 subjects from China to characterize alterations of the gut virome in COPD. Lower richness and diversity of the gut virome were observed in the COPD subjects compared with the healthy individuals. Sixty-four viral species, including Clostridium phage, Myoviridae sp., and Synechococcus phage, showed positive relationships with pulmonary ventilation functions and had markedly declined population in COPD subjects. Multiple viral functions, mainly involved in bacterial susceptibility and the interaction between bacteriophages and bacterial hosts, were significantly declined in COPD. In addition, COPD was characterized by weakened viral-bacterial interactions compared with those in the healthy cohort. The gut virome showed diagnostic performance with an area under the curve (AUC) of 88.7%, which indicates the potential diagnostic value of the gut virome for COPD. These results suggest that gut virome may play an important role in the development of COPD. The information can provide a reference for the future investigation of diagnosis, treatment, and in-depth mechanism research of COPD.
IMPORTANCE: Previous studies showed that the bacteriome plays an important role in the progression of chronic obstructive pulmonary disease (COPD). However, little is known about the involvement of the gut virome in COPD. Our study explored the disease-specific virome signatures of patients with COPD. We found the diversity and compositions altered of the gut virome in COPD subjects compared with healthy individuals, especially those viral species positively correlated with pulmonary ventilation functions. Additionally, the declined bacterial susceptibility, the interaction between bacteriophages and bacterial hosts, and the weakened viral-bacterial interactions in COPD were observed. The findings also suggested the potential diagnostic value of the gut virome for COPD. The results highlight the significance of gut virome in COPD. The novel strategies for gut virome rectifications may help to restore the balance of gut microecology and represent promising therapeutics for COPD.
Methods and systems for pharmacy modeling are described. The risk adjusted pharmacy predictive model is created from member data, claims data, and population data. This model can be used to compare the actual pharmacy performance to an expected actual pharmacy performance value, which can be used to identify pharmacies at risk or not performing to an acceptable level. The model can be used for adherence and generic drug utilization ratings of pharmacies. The pharmacy can be judged on a therapy class by therapy class basis with factors that reflect the demographic, socio-economic, location, benefits attributes, etc. that actually affect the performance of the pharmacy and may assist in determining the quality of care by a pharmacy.
The current standard of care does not include any interventions for smoke-free home adoption or referrals to tobacco treatment resources. At the end of the primary endpoint (6 months), control participants will be offered the intervention.
PURPOSE:To obtain a hair cosmetic having excellent conditioning property by using a specific modified solid silicone polymer, a cationic surfactant, an oil and fat, an organic liquid containing at least one hydroxyl group in one molecule and compatible with water, and water as essential components. CONSTITUTION:The objective hair cosmetic contains (A) a modified silicone polymer containing one or more alkoxy groups in the molecule and having a melting point of >=30 deg.C [e.g. a compound of formula ((l) is 1-100; (m) is 1-50)], (B) a cationic surfactant (e.g. a quaternary ammonium salt), (C) an oil and fat (e.g. liquid paraffin and lanolin), (D) an organic liquid having one or more hydroxyl groups in one molecule and compatible with water (e.g. polyhydric alcohol) and (E) water. The hair treated with the hair cosmetic is free from oily feeling even in wet state or dried state, has excellent smoothness and flexibility, gives bulky and light texture and moist feeling and exhibits excellent antistatic effect. The cosmetic has excellent storage stability.
We aim to use an online survey to collect data from participants. It is estimated that this survey will take 10 minutes to complete. The first part of the survey asks questions about the participant including what stakeholder group best describes them. The second part asks them about what outcomes are important in pharmacy research and in the management of kidney disease.
The utility model discloses a branched chain amino acid buccal tablet belongs to preparation technical field. The utility model discloses a branched chain amino acid buccal tablet adopts the four -layer structure, is in proper order from outside to inside: first acid layer, instant branched chain amino acid bisque, second acid layer, the loyal sugar layer of unit. The utility model discloses with instant branched chain amino acid bisque clamp between first acid layer, second acid layer, branched chain amino acid's bitter taste has been reduced through the acid. Acid and the bitter stronger sour taste that mixes the back production have been alleviated through the sweet taste that the loyal sugar layer of unit provided to while, and can cover the special taste of amino acid product. Adopt instant branched chain amino acid powder, reduced dissolve time and the dwell time of branched chain amino acid in the oral cavity, reduced the discomfort of smell and taste. The utility model discloses a branched chain amino acid buccal tablet, it is sweet and sour moderate, changed edible health food's psychology impression.
Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.
The feasibility of outpatient TPM has been well demonstrated.(Bianco \& Martínez-Salamanca, 2016; Merrick et al., 2016; Smith et al., 2014) New technology now allows for fusion of MRI images with TPM devices, allowing for targeting of cancerous-appearing lesions on MRI. Such technology that fuses MRI-imaging with TRUS biopsy has become routine in U.S. clinical practice, with improved cancer detection rates as compared with standard TRUS.(Ahmed et al., 2017; Robertson, Emberton, \& Moore, 2013)

This randomized trial will compare the safety and efficacy of TPM versus TRUS biopsies performed in the outpatient setting. Men will be randomized to receiving either TPM or TRUS targeted biopsy. All men will receive a urine culture within 2 weeks of biopsy and will be started on antibiotic prophylaxis prior to biopsy in accordance with AUA antimicrobial prophylaxis guidelines. Men with a positive urine culture will be treated with culture-specific antibiotics and must have a documented negative urine culture prior to biopsy.
Osteosarcoma is the most common primary malignant bone tumor in adolescents, and lung metastasis is the main cause of its poor prognosis. Our previous data on the basis of second-line chemotherapy combined with VEGFRi targeted therapy for patients with lung metastases from osteosarcoma showed that some patients with early diagnosis of lung metastases may achieved long-term tumor-free survival upon prompt treatment. However, plasma biomarker for the early detection of recurrent osteosarcoma is still lacking to date. Our preliminary studies indicate that exosome is a potential source of liquid biomarker for the early diagnosis of osteosarcoma lung metastasis. We, therefore, have developed a microfluidic biochip based on nano-zinc oxide microcolumns. This chip can quickly and efficiently screen and capture exosomes and achieve quantitative and qualitative detection of exosome and its subgroups. This technology may be able to achieve early sensitive exosome quantification for lung metastasis of osteosarcoma. But the clinical efficacy and utility of the microfluidic chip based exosome detection for the early diagnosis osteosarcoma recurrence remains to be validated.

This research plan uses our newly developed microfluidic chip technology to capture and efficiently capture exosomes for quantitative and qualitative and marker screening, and establish a combination of exosome subgroups level as a biomarker for the early diagnosis of osteosarcoma lung metastasis.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world, with epidemiological studies indicating a 25% prevalence. NAFLD is considered to be a progressive disease that progresses from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH), then to liver fibrosis, and finally to cirrhosis or hepatocellular carcinoma (HCC). Existing research has mostly elucidated the etiology of NAFLD, yet its particular molecular processes remain uncertain. Long non-coding RNAs (LncRNAs) have been linked in a wide range of biological processes in recent years, with the introduction of microarray and high-throughput sequencing technologies, and previous studies have established their tight relationship with several stages of NAFLD development. Existing studies have shown that lncRNAs can regulate the signaling pathways related to hepatic lipid metabolism, NASH, NASH-related fibrosis and HCC. This review aims to provide a basic overview of NAFLD and lncRNAs, summarize and describe the mechanisms of lncRNAs action involved in the development of NAFLD, and provide an outlook on the future of lncRNAs-based therapy for NAFLD.
One-hour session three times per week for 4 weeks. Participants will receive anodal tDCS (1.5 mA) to the dorsolateral prefrontal cortex (dlPFC) for 20 minutes at the beginning of each session. Following each tDCS session, the participants will complete a sensations questionnaire.The basis for each session will be task-based practice of client-chosen goals and the use of cognitive strategies using CO-OP.
BACKGROUND: The benefits of prophylactic ureteral stent placement during colorectal surgery remain controversial. This study aimed to determine the incidence of ureteral injury in colorectal operations, assess the complications associated with stent usage, and determine whether their use leads to earlier identification and treatment of injury.
METHODS: This was a retrospective study of patients undergoing colorectal abdominal operations between 2015 and 2021. Variables were examined for possible association with ureteral stent placement. The primary study endpoint was ureteral injury identified within 30 days postoperatively.
RESULTS: Of 6481 patients who underwent colorectal surgery, 970 (15%) underwent preoperative ureteral stent placement. The use of stents was significantly associated with a higher American Society of Anesthesiologists classification, wound classification, and longer duration of surgery. A ureteral injury was identified in 28 patients (0.4%). Of these patients, 13 had no stent, and 15 had preoperative stents placed. After propensity matching, stent use was associated with an increased risk of hematuria and urinary tract infection. Ureteral injury was identified intraoperatively in 14 of 28 patients (50.0%) and was not associated with ureteral stent use (P = .45).
CONCLUSION: Iatrogenic ureteral injury was uncommon, whereas preoperative stent placement was relatively frequent. Earlier recognition of iatrogenic ureteral injury is not an expected advantage of preoperative ureteral stent placement.
The present invention discloses Chinese traditional medicine for treating rheumatoid arthritis, and a preparing technology thereof. The Chinese medicine for treating rheumatoid arthritis comprises crude medicine of 8 to 10 portions of ant, 2 to 3 portions of milk vetch, 1 to 2 portions of notoginseng, 1 to 2 portions of paris rhizome, 0.8 to 1.2 portions of geranium and 0.8 to 1.2 portions of rhizoma homalonemae. The preparing technology comprises that milk vetch are taken according to a recipe and pulverized to fine powder for preparation. The rest 5 kinds of crude medicine are taken according to the recipe, and a proper amount of ethanol is added for soaking and reflux extraction. The medicine is repeatedly extracted for 2 to 3 times, and the extract is merged and stood to obtain supernatant liquid which is concentrated to obtain thick paste. The prepared milk vetch powder is added and uniformly mixed with the thick paste. Dry extract is obtained by dryness, and pulverized and sieved, and is added with a proper quantity of supplementary materials, and a required dosage form is made by a conventional method. The traditional Chinese medicine has good curative effect, the side effect is small, and the traditional Chinese medicine can be used for treating both manifestation and root cause of disease. The fabrication technology has the advantages of low cost and simple manufacturing technology.
Patients age 40-70 who fulfill the American College of Rheumatology (ACR) criteria for a diagnosis of primary osteoarthritis are considered eligible. This group has been prescribed naproxen (1000 mg/day) for a minimum of two weeks.
Aberrant long non-coding RNA (lncRNA) expression has been shown to be involved in the pathological process of pre-eclampsia (PE), yet only a small portion of lncRNAs has been characterized concerning the function and molecular mechanisms involved in PE. This study aimed to investigate the regulatory mechanism of the lncRNA AC092100.1 (AC092100.1) in angiogenesis in PE. In our study, bioinformatics analysis was performed to screen for differentially expressed lncRNAs between normal subjects and PE patients. The levels of AC092100.1 in placental tissues of patients with or without PE were validated using qRT-PCR. The effect of AC092100.1 overexpression on the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) was investigated. The binding of AC092100.1 and YT521-B homology domain-containing 2 (YTHDC2) was predicted and verified. The effect of AC092100.1/YTHDC2 on the expression of vascular endothelial growth factor-A (VEGFA) in HUVECs was determined. Finally, a PE mice model was conducted. Fetal mouse growth, the abundance of mesenchymal morphology markers, including hypoxia-inducible factor 1-alpha (HIF-1α), soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), Slug, and Vimentin, and endothelial markers, including placental growth factor (PLGF), CD31, and vascular endothelial (VE)-cadherin, in placental tissues were assessed. Here, we found that AC092100.1 was abnormally downregulated in placental tissues from PE patients. We established that AC092100.1 overexpression promoted HUVEC proliferation, migration, and tube formation in vitro. Mechanistically, AC092100.1 induced the accumulation of YTHDC2 and VEGFA through binding to YTHDC2 in HUVECs. Inhibition of YTHDC2 or VEGFA reversed AC092100.1-promoted tube formation. AC092100.1 overexpression contributed to alleviating fetal growth disorder, decreased levels of sEng, HIF-1α, sFlt-1, Slug, and Vimentin, and increased levels of VEGFA, PLGF, CD31, and VE-cadherin in PE mice. Our findings provided evidence supporting the role of the AC092100.1/YTHDC2/VEGFA axis in regulating angiogenesis, which demonstrated a therapeutic pathway for PE targeting angiogenesis.
<P>PROBLEM TO BE SOLVED: To freely lay out image data on a computer screen for observing it and printing it by a printer and to easily reuse the data.  <P>SOLUTION: An image with an optional layout is formed when a desired layout is formed by a layout formation means, target image data are designated by a designation means (drag), and the designated image data designated by an image data registration means are pasted (drop) in a predetermined position to be inputted. The image data inputted into a patient folder having a file name formed according to essential items composed of a patient number, a date and a time, an image type, and a section, are stored. When the patient number is inputted, the image data are observed or printed from the patient folder. Contents of the data are determined from the file name to be reused.  <P>COPYRIGHT: (C)2004,JPO
Patients will be treated with injectable methylprednisolone sodium succinate as described in Arm A. After Week 4, Inebilizumab to prevent relapse will be introduced according to the indication.
558,112. Dental cements. ABRAHAM, H. M. April 16, 1942, No. 5023. [Class 70] Dental filling cements are reinforced by incorporating finely powdered metal, other than tin or metal alloy, not attacked by saliva or by any constituent of the cement. More than one metal &c. may be used and the addition may be made during or after the manufacture of the cement. Metals instanced are steel, stainless steel, iron, manganese, chromium, palladium, rhodium, gold and platinum. An example specifies a liquid-setting dental cement, the liquid component including phosphoric acid, zinc oxide, zinc phosphate and aluminium phosphate and the powdered component alumina felspar, fluor spar, quartz sand, and zinc and manganese oxides fused at 1,800‹C. ground and mixed with 1 per cent. of stainless steel powder.
BACKGROUND & AIMS: Gastrointestinal angiodysplasias are vascular anomalies that may result in transfusion-dependent anemia despite endoscopic therapy. An individual patient data meta-analysis of cohort studies suggests that octreotide decreases rebleeding rates, but component studies possessed a high risk of bias. We investigated the efficacy of octreotide in reducing the transfusion requirements of patients with angiodysplasia-related anemia in a clinical trial setting.
METHODS: The study was designed as a multicenter, open-label, randomized controlled trial. Patients with angiodysplasia bleeding were required to have had at least 4 red blood cell (RBC) units or parental iron infusions, or both, in the year preceding randomization. Patients were allocated (1:1) to 40-mg octreotide long-acting release intramuscular every 28 days or standard of care, including endoscopic therapy. The treatment duration was 1 year. The primary outcome was the mean difference in the number of transfusion units (RBC + parental iron) between the octreotide and standard of care groups. Patients who received at least 1 octreotide injection or followed standard of care for at least 1 month were included in the intention-to-treat analyses. Analyses of covariance were used to adjust for baseline transfusion requirements and incomplete follow-up.
RESULTS: We enrolled 62 patients (mean age, 72 years; 32 men) from 17 Dutch hospitals in the octreotide (n = 31) and standard of care (n = 31) groups. Patients required a mean number of 20.3 (standard deviation, 15.6) transfusion units and 2.4 (standard deviation, 2.0) endoscopic procedures in the year before enrollment. The total number of transfusions was lower with octreotide (11.0; 95% confidence interval [CI], 5.5-16.5) compared with standard of care (21.2; 95% CI, 15.7-26.7). Octreotide reduced the mean number of transfusion units by 10.2 (95% CI, 2.4-18.1; P = .012). Octreotide reduced the annual volume of endoscopic procedures by 0.9 (95% CI, 0.3-1.5).
CONCLUSIONS: Octreotide effectively reduces transfusion requirements and the need for endoscopic therapy in patients with angiodysplasia-related anemia.
CLINICALTRIALS: gov, NCT02384122.
Phase I/II, open-label PK and initial safety analysis. TAVT-18 administered orally twice/daily to achieve precision dosing target of 10 ng/ml. Whole blood sirolimus levels are assessed at defined intervals on days 1, 7, and 14. After day 14, participants can elect to continue open-label treatment with TAVT-18 until 12 months of age. Final developmental outcomes are assessed at 24 months of age.