anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental and genetic factors contribute to the onset of pruritus. Moreover, itch can become a major burden when it becomes chronic. Interestingly, the rare Collagen VI alpha 5 (COL6A5) gene variant p.Glu2272* has been identified in two families and an independent patient with chronic neuropathic itch. These patients showed reduced COL6A5 expression in skin and normal skin morphology. However, little progress has been made until now toward understanding the relationships between this mutation and chronic itch. Therefore, we developed the first mouse model that recapitulates COL6A5-p.Glu2272* mutation using the CRISPR-Cas technology and characterized this new mouse model. The mutant mRNA, measured by RT-ddPCR, was expressed at normal levels in dorsal root ganglia and was decreased in skin. The functional exploration showed effects of the mutation with some sex dysmorphology. Mutant mice had increased skin permeability. Elevated spontaneous scratching and grooming was detected in male and female mutants, with increased anxiety-like behavior in female mutants. These results suggest that the COL6A5-p.Glu2272* mutation found in patients contributes to chronic itch and induces in mice additional behavioral changes. The COL6A5-p.Glu2272* mouse model could elucidate the pathophysiological mechanisms underlying COL6A5 role in itch and help identify potential new therapeutic targets.
The invention relates to Tango-71, Tango-79, and Tango-81 polypeptides, nucleic acid molecules encoding Tango-71, Tango-79, and Tango-81, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
In the course of clarifying genes causative of Rim3 by positional cloning and candidate gene mapping, novel Gasdermin-homologous genes are isolated and named mouse Gasdermin A-2 and mouse Gasdermin A-3. Further, these genes are compared with human genome draft sequences and thus a human Gasdermin gene (named human Gasdermin A-1) is found out. This gene is isolated by the PCR method. The human Gasdermin A-1 gene is transferred into a cancer cell line and the ratio of colony formation is examined. Thus, it is found out that this gene has a carcinostatic effect. As the results of an examination on the occurrence of other Gasdermin-homologous genes, it is surprisingly found out that there exists a Gasdermin family.
Thecontrol group was performed with 45 patients. Any application was not performed for the control group.
Illuminating associations between diseases and genes can help reveal the pathogenesis of syndromes and contribute to treatments, but a large number of associations remained unexplored. To identify novel disease-gene associations, many computational methods have been developed using disease and gene-related prior knowledge. However, these methods remain of relatively inferior performance due to the limited external data sources and the inevitable noise among the prior knowledge. In this study, we have developed a new method, Self-Supervised Mutual Infomax Graph Convolution Network (MiGCN), to predict disease-gene associations under the guidance of external disease-disease and gene-gene collaborative graphs. The noises within the collaborative graphs were eliminated by maximizing the mutual information between nodes and neighbors through a graphical mutual infomax layer. In parallel, the node interactions were strengthened by a novel informative message passing layer to improve the learning ability of graph neural network. The extensive experiments showed that our model achieved performance improvement over the state-of-art method by more than 8 % on AUC. The datasets, source codes and trained models of MiGCN are available at https://github.com/biomed-AI/MiGCN.
Fresh embryo transfer will not be undertaken in this group. Embryos will be frozen by vitrification or slow freezing at cleavage or blastocyst stage according to standard agreed local protocols. Women will be contacted after 4 weeks and arrangements made for frozen embryo transfer.
BACKGROUND AND AIMS: Few researchers have compared the effectiveness of traditional and novel obesity indicators in predicting stroke incidence. We aimed to evaluate the associations between six obesity indices and stroke risk, and to further identify the optimal indicator.
METHODS AND RESULTS: A total of 14,539 individuals from the Rural Chinese Cohort Study were included in the analyses. We used the Cox proportional hazards regression models to evaluate the association between six obesity indices (including body mass index [BMI], waist circumference [WC], conicity index [C-index], lipid accumulation product [LAP], visceral adiposity index [VAI], and Chinese visceral adiposity index [CVAI]) and stroke risk. Receiver operating characteristic curves were employed to compare their predictive ability on stroke risk. During a median follow-up period of 11.13 years, a total of 1257 cases of stroke occurred. In the multiple-adjusted Cox regression model, WC, BMI, C-index, and CVAI were positively associated with ischemic stroke (P < 0.01) rather than hemorrhagic stroke risk. Dose-response analyses showed a linear correlation of WC, BMI, C-index, and LAP (Poverall <0.05, and Pnonlinear >0.05), but a non-linear correlation of CVAI (Poverall <0.05, and Pnonlinear <0.05) with the risk of ischemic stroke. CVAI demonstrates the highest areas under the curves (AUC: 0.661, 95% CI: 0.653-0.668), indicating a superior predictive ability for ischemic stroke occurrence compared to other five indices (P < 0.001).
CONCLUSION: WC, BMI, C-index, LAP, and CVAI were all positively related to the risk of ischemic stroke, among which CVAI exhibited stronger predictive ability for ischemic stroke.
The investigators plan to use \[18F\](+/-)NOS (the F stands for fluorine and NOS stands for Nitric Oxide Synthase, the name for the investigational radioactive drug that targets iNOS) and positron emission tomography (PET) imaging as a measure of lung inflammation. PET is a machine that detects radiation and generates pictures using a donut shaped scanner similar in appearance to an x-ray "CAT" scan.

In order to show that \[18F\](+/-)NOS-PET is related to the amount of inflammation, the investigators first need to create a state of controlled lung inflammation that can be measured and quantified. "Controlled lung inflammation" means a reaction in the lungs that is similar to that which occurs during lung infection (increased respiratory secretions, and cough). It is "controlled" because the investigators will not be using anything alive or contagious (it will not spread from one part of your body to another, and cannot spread to another person) and a small area in only one lung will be affected. In order to create this state of controlled lung inflammation, the investigators plan to put a small amount of endotoxin into a single small section of the lung using a bronchoscope (a long, flexible, narrow tube that is passed through the nose or the mouth into the airways of the lung). This use of endotoxin is considered investigational. The investigators have received permission from the FDA to use endotoxin in this research study.
Many children are believed to under accommodate (have a lag of accommodation) when looking at near targets. If this occurs, the retinal image is out of focus. Children who have a lag of accommodation may have difficulty in focusing their eyes at near for long periods of time. This difficulty could reduce their ability to read fluently. Children with above average lags of accommodation will be randomly assigned to a group which receives special reading glasses or a group which does not. The groups will be assessed using a standard test for reading fluency.
BACKGROUND: Leg length discrepancy (LLD) is common in youth and is cause by several conditions. Long leg X-rays is the gold standard technique of measuring LLD. It is highly accurate and reliable compared to clinical method, but expose the subject to radiation. Instrumented Gait Analysis (IGA) serves not only as a means to measure joint kinematics during gait but also as a valuable tool for assessing Leg Length Discrepancy (LLD) while standing.
RESEARCH QUESTION: The purpose of this study was to compare different methods of determining the LLD in paediatric population. We hypothesize that IGA using joint centres is more accurate and precise than the tape measurement.
METHODS: Thirty-one patients with mean age 12.3 (SD=2.4) years were retrospectively included in the study. Their LLD varied between 0 and 36 mm. Three methods for determining LLD were compared to radiography using Bland-Altman analysis: 1. Tape measurement, 2. IGA, summarizing the distance from the spina iliaca anterior superior to the medial malleolus marker via the medial knee condyle marker. 3. IGA, summarizing distances between ankle, knee, and hip joints centres where the latter is calculated with different equations.
RESULTS: The IGA joints method performed better than the tape measurement or IGA markers method. The equations of Davis calculating the hip joint centre had the highest accuracy with mean difference to radiography of 0.7 mm (SD=6.3). The simple Harrington method resulted in a slightly reduced accuracy but higher precision 0.9 mm (SD=6.2). The Harrington method with leg length as input was less accurate 1.0 mm (SD=6.7), but was still considerably better than the tape measurement 1.8 mm (SD=7.0) or IGA markers method 1.1 mm (SD=11.5).
SIGNIFICANCE: Determining LLD with IGA using the distances between ankle, knee and hip joints centres is a feasible method that can be applied in clinical practice to calculate LLD.
Various embodiments are generally directed to techniques for facilitating veterinary services, such as with a schedule administrator, for instance. Many embodiments include a schedule administrator for generating schedule data based on planning data. In many such embodiments, the schedule data may be dynamically updated based on updated, or additional, planning data. In various embodiments, the schedule data may include a schedule of appointments for veterinary services. In some embodiments, the schedule data may include routes for veterinary service providers. In several embodiments, the schedule administrator may utilize one or more artificial intelligence algorithms to generate one or more portions of the schedule data, such as the schedule of appointments and/or the routes for veterinary service providers. In many embodiments, the artificial intelligence algorithms may be trained on historical data comprising a plurality of historical appointments.
BACKGROUND: Traumatic brain injury patients who require neurosurgical intervention are at the highest risk of worsening intracranial hemorrhage. This subgroup of patients has frequently been excluded from prior research regarding the timing of venous thromboembolism chemoprophylaxis. This study aims to assess the efficacy and safety of early venous thromboembolism chemoprophylaxis in patients with traumatic brain injuries requiring neurosurgical interventions.
METHODS: This is a single-center retrospective review (2016-2020) of traumatic brain injury patients requiring neurosurgical intervention admitted to a level I trauma center. Interventions included intracranial pressure monitoring, subdural drain, external ventricular drain, craniotomy, and craniectomy. Exclusion criteria included neurosurgical intervention after chemoprophylaxis initiation, death within 5 days of admission, and absence of chemoprophylaxis. The total population was stratified into Early (≤72 hours of intervention) versus Late (>72 hours after intervention) chemoprophylaxis initiation.
RESULTS: A total of 351 patients met the inclusion criteria, of whom 204 (58%) had early chemoprophylaxis initiation. Overall, there were no significant differences in baseline and admission characteristics between cohorts. The Early chemoprophylaxis cohort had a statistically significant lower venous thromboembolism rate (5% vs 13%, P < .001) with no increased risk of worsening intracranial hemorrhage (10% vs 13%, P = .44) or neurosurgical reintervention (8% vs 10%, P = .7). On subgroup analysis, a total of 169 patients required either a craniotomy or a craniectomy before chemoprophylaxis. The Early chemoprophylaxis cohort had statistically significant lower venous thromboembolism rates (2% vs 11%, P < .001) with no increase in intracranial hemorrhage (8% vs 11%, P = .6) or repeat neurosurgical intervention (8% vs 10%, P = .77).
CONCLUSION: Venous thromboembolism prophylaxis initiation within 72 hours of neurosurgical intervention is safe and effective. Further prospective research is warranted to validate the results of this study.
Tablets containing betahistine dihydrochloride. Administered three times daily as 1 tablet per time. Total daily dose is 48 mg oral betahistine dihydrochloride.
The invention relates to a parkinsonism health risk assessment method based on multi-modal data, which comprises UPDRS scoring, population basic condition data and sensor data, and a multi-modal data set is constructed; preprocessing sensor data by Gaussian filtering; and constructing a convolutional neural network model, and constructing a sensor data characteristic extraction method based on deep learning. Incorporating manual features, computing sensor data is a significant feature for parkinsonism health risk assessment. Demographic data is integrated and incorporated into the model. Model training and prediction, integrating features extracted by convolutional neural networks, manual features and demographic data features. And constructing a feature representation consistency module based on the three types of features. And finally, training the model and predicting the sample of the unknown label. The accuracy of the method and the model in parkinsonism risk prediction reaches 81.4 percent.
PURPOSE:To sterilize the mixture of chemicals and a thermoplastic polymer sealed in a molded vessel by radiation sterilization and to form a sterilized mixture in the case of sealing the mixture in the vessel which can seal the mixture, heating to melt is, centrifugal molding it, cooling to solidify it and forming formulations. CONSTITUTION:A mixture of chemicals 1 and a thermoplastic polymer 2 is put in a Teflon breaker, heated to be melted at 120 deg.C, and then cooled to be solidified. The obtained solid material is comminuted by a vibrating mixer mill. The powder is filled in a molding vessel, sealed, and dry heated to be sterilized by an autoclave or radiation sterilized. Then, it is centrifugally separated by a centrifugal separator, and molded in a stylus state. The obtained styluslike composition is cooled to be solidified, removed from the vessel in a sterilized environment to preparations. Thus, the preparations containing no bubbles and having uniform strength can be easily obtained without bacteria.
INTRODUCTION: Using smartphones has increased exponentially, especially after the COVID-19 pandemic. However, there is a relationship between neck flexion angle during working with a smartphone and neck musculoskeletal disorders. Therefore, this study compares the effect of Kinesio taping and Repeated End Range Movements (RERM) on head and neck flexion angles changes during texting and discomfort after texting with a smartphone.
METHOD: Twenty-four smartphone users participated in this cross-over study. All of 24 subjects were experimented with the control, RERM and taping conditions. They filled Numeric Rating Scale questionnaire before and after 30 min of texting. In addition, their head and neck flexion angles were measured during the task by photogrammetry.
RESULTS: In the RERM group, individuals felt significantly less discomfort than the control group after the task (P = 0.032). Although the slope of average head and neck flexion angles linear regression lines of all the three groups was positive before the break time, it became negative in the taping and control groups after the break time. In addition, the linear regression of average head and neck flexion angles of the RERM group was significantly different (P < 0.001).
CONCLUSION: RERM can effectively maintain normal head and neck movement pattern during and reduce neck discomfort after texting on smartphone.
PURPOSE:To obtain a preserving solution for gelatinized impression materials, e.g. alginic acid based impression materials, etc., which is a liquid at ordinary temperature, consists essentially of a water-immiscible organic liquid and has excellent holding property of impression accuracy. CONSTITUTION:A preserving solution which is a liquid at ordinary temperature and consists essentially of a water-immiscible organic liquid, preferably chlorofluorohydrocarbon, particularly a mixture of tetrachlorodifluoroethane with isooctane, especially an azeotropic composition containing about 93-95wt% of the former and about 5-7wt% of the latter and useful for gelatinized impression materials. If this preserving solution is used, the impression accuracy of alginic acid based impression materials can be held for about 24hr or more and is extremely preferred for collecting gypsum molds thereof but, of course, can also be used for other impression materials, e.g. silicone based, polysulfide based impression materials, etc. Furthermore, the gelatinized impression molds are preferably taken out of the preserving solution, thoroughly washed with water and used in taking gypsum molds.
NEW MATERIAL:A protein having an amino acid sequence of Met-glu-Leu-Gln- Val-Ser-Ser-Gly-Phe-Val as a part of the polypeptide structure and reactive with an anti-Fcepsilon receptor antibody. USE:A protein for the isolation of genetic information coding human IgE linking factor or human Fcepsilon receptor protein. PREPARATION:Human B cell, human T cell, etc., having class-specific Fcepsilon receptor on the surface is cultured in a proper medium preferably at 36-37 deg.C, 7-8 pH and CO2 concentration of 5-7% e.g. for 1 week. The supernatant liquid of the cultured product is treated e.g. by affinity chromatography using an anti-Fcepsilon receptor monoclonal antibody.
PURPOSE:To enhance operability while the high function possessed by a patient monitor apparatus is held by setting only necessary function from a plurality of functions to select the same. CONSTITUTION:Three expanding function, setting function and presetting function are displayed on the picture of a patient monitor apparatus in a key system. When the part of the expanding function F1 is pushed by a finger, said part lights and other parts go out to set the expanding function. When the expanding function is set, the picture is changed over and various modes to be selected in the expanding function are displayed. Now, when a user desires to select a SIGMA display mode F11, the part thereof is pushed to light and other parts go out. When the SIGMA display mode F11 is selected, the picture is changed over and SIGMA display data F111 is displayed. When there is no mode to be selected in a picture and a user does not perform any operation, it in judged that there is no necessary mode and no processing is performed.
Blood and bone marrow is collected at baseline, 3 months after completion of induction therapy, 2 months after completion of consolidation therapy, 1 year after completion of study treatment, and at disease relapse. Samples are analyzed by FISH for interphase cytogenetics, PCR for IgV_H mutational status, flow cytometry for surface expression of CD38 cells, western blot to assess Mcl-1, Bcl-2, BAK-1, ATM, ZAP-70, and Bar expression, and sequencing for p53 and ATM function.
Embodiments of the present disclosure provide for methods, system, and architecture for automatically generating curated interventions for modifying patient behaviors within an end user application is disclosed herein. A patient behavior is observed including a set of features. A computer program stored on a non-transitory computer-readable medium is used to select the patient and the observed patient behavior. The selected patient and the selected patient behavior are loaded into a trained intervention generating system. The trained intervention generating system generates an intervention responsive to the selected patient and the selected patient behavior inputs using artificial intelligent neural networks. The intervention recommender system is accessible to caregiving users via an interactive cloud computing architecture and service incorporating sensors, camera, Internet of Things technology for monitoring patient behaviors and daily activities.
A method of measuring rinse properties of a composition from a surface. The method includes providing a treatment composition comprising a UV fluorescent dye. The method also includes taking a first image of a surface. The method also includes applying the treatment composition to the surface after taking the first image. The method also includes taking a second image of the surface after applying the treatment composition to the surface. The method also includes rinsing the surface with water after taking the second image. The method also includes taking a third image of the surface after rinsing the surface. The method also includes analysing the first image, the second image, and the third image to quantify an amount of the treatment composition remaining on the surface after rinsing the surface.