anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a new approach to cancer therapy.  <P>SOLUTION: The treatment is for cancer, particularly the treatment for cancers of the central nervous system, such as glioblastoma multiforme. A dual therapeutic approach is provided, which includes the administration of a dendritic cell-based cancer vaccine and a regimen of chemotherapy. These two therapies can be simultaneously administered with each other and/or simultaneously with the initial vaccination before the chemotherapy. In various embodiments, the dendritic cell-based cancer vaccine includes either primed or unprimed dendritic cells; for instance, the dendritic cells may be autologous tumor antigen-presented dendritic cells. The dual therapeutic approach of the instant invention beneficially influences the chemosensitivity of a mammal with cancer.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Spatial patterns are common in infectious disease epidemiology. Disease mapping is essential to infectious disease surveillance. Under a group testing protocol, biomaterial from multiple individuals is physically combined into a pooled specimen, which is then tested for infection. If the pool tests negative, all contributing individuals are generally assumed to be uninfected. If the pool tests positive, the individuals are usually retested to determine who is infected. When the prevalence of infection is low, group testing provides significant cost savings over traditional individual testing by reducing the number of tests required. However, the lack of statistical methods capable of producing maps from group testing data has limited the use of group testing in disease mapping. We develop a Bayesian methodology that can simultaneously map disease prevalence using group testing data and identify risk factors for infection. We illustrate its real-world utility using two datasets from vector-borne disease surveillance.
Participants in the placebo group 10-12 postpartum. at hours and 14-16. Two pairs of TENS electrodes were placed at the same time as the intervention group. TENS electrodes were attached to the participants in this group for 30 minutes, the device was operated but no electric current was applied.
Acamprosate calcium delayed-release tablets are supplied as an enteric-coated tablet for oral administration. Acamprosate calcium, USP is a synthetic compound with a chemical structure similar to that of the endogenous amino acid homotaurine, which is a structural analogue of the amino acid neurotransmitter γ-aminobutyric acid and the amino acid neuromodulator taurine. Its chemical name is calcium bis [3-(acetylamino) propane-1-sulfonate]. Its chemical formula is C10H20CaN2O8S2 and molecular weight is 400.5 g/mol. Its structural formula is:

Acamprosate calcium, USP is a white to almost white powder, odorless or nearly odorless powder. It is freely soluble in water and practically insoluble in alcohol and methylene chloride.

Each acamprosate calcium delayed-release tablet contains acamprosate calcium, USP 333 mg, equivalent to 300 mg of acamprosate. Inactive ingredients in acamprosate calcium delayed-release tablets include: colloidal silicon dioxide, crospovidone, methacrylic acid copolymer dispersion, magnesium silicate, magnesium stearate, microcrystalline cellulose, polyvinyl pyrollidone, propylene glycol, sodium starch glycolate, and talc. Sulfites were used in the synthesis of the drug substance and traces of residual sulfites may be present in the drug product.
Brachycephalic obstructive airway syndrome (BOAS) is a highly prevalent respiratory disease affecting popular short-faced dog breeds such as Pugs and French bulldogs. BOAS causes significant morbidity, leading to poor exercise tolerance, sleep disorders and a shortened lifespan. Despite its severity, the disease is commonly missed by owners or disregarded by veterinary practitioners. A key clinical sign of BOAS is stertor, a low-frequency snoring sound. In recent years, a functional grading scheme has been introduced to semi-objectively grade BOAS based on the presence of stertor and other abnormal signs. However, correctly grading stertor requires significant experience and adding an objective component would aid accuracy and repeatability. This study proposes a recurrent neural network model to automatically detect and grade stertor in laryngeal electronic stethoscope recordings. The model is developed using a novel dataset of 665 labelled recordings taken from 341 dogs with diverse BOAS clinical signs. Evaluated via nested cross validation, the neural network predicts the presence of clinically significant BOAS with an area under the receiving operating characteristic of 0.85, an operating sensitivity of 71% and a specificity of 86%. The algorithm could enable widespread screening for BOAS to be conducted by both owners and veterinarians, improving treatment and breeding decisions.
Optimization of the time to liberate the patient from mechanical ventilation should be balanced between the risks associated with failed extubation and those related to prolonged mechanical ventilation. Weaning failure is associated with major complications. Even when weaning protocols and clinical predictors have been used to improve the weaning outcome, there is still a significant proportion of patients who fail to breath spontaneously with significant risks of pneumonia, prolonged mechanical ventilation and increased morbidity and mortality rate. Electrical activity of the diaphragm, a mirror of the respiratory drive and now available on an ICU ventilator may help to predict in a more accurate way the weaning outcome. The patients will be ventilated in NAVA with the titration method (1). As soon as patients passed successfully a daily screening EAdi will be measured during a spontaneous breathing trial.
OBJECTIVES: The aim of the study was to determine the effects of training on inter-rater reliability and agreement of Feline Grimace Scale (FGS) scoring by small animal practitioners.
METHODS: Seven small animal veterinarians were asked to score a total of 50 images of cats in varying degrees of pain before and after training in FGS scoring. Participant scores were compared with those of an expert rater. Inter-rater reliability was analyzed using the intraclass correlation coefficient (ICC) before and after training (ICC <0.50 = poor reliability, 0.50-0.75 = moderate reliability, 0.76-0.90 = good reliability and >0.90 = excellent reliability). The Bland-Altman method was used to analyze the limits of agreement (LoAs) and bias between participants and the expert rater.
RESULTS: After training, the ICC classification improved for each action unit (ear position, orbital tightening, muzzle tension, whiskers change and head position). The inter-rater reliability for the total FGS ratio scores before and after the FGS training session was moderate (ICC = 0.75; 95% confidence interval [CI] 0.66-0.83) and good (ICC = 0.80; 95% CI 0.73-0.87), respectively. Before training, LoAs were -0.277 to 0.310 with a bias of 0.016. After training, LoAs were -0.237 to 0.255 with a bias of 0.008. The bias was low (<0.1) both before and after training and LoAs did not span the FGS analgesic threshold (0.39).
CONCLUSIONS AND RELEVANCE: Training in FGS scoring improved inter-rater reliability and agreement among seven small animal veterinarians and the veterinarians' skills in pain assessment.
The invention belongs to the technical field of medicine preparation. The invention provides a hydrogen slow-release solution and a preparation method and application thereof. The hydrogen sustained-release solution is prepared by taking levorotatory polylactic acid, a magnesium simple substance, chloroform and a phosphate buffer solution as raw materials. Mixing levorotatory polylactic acid, a magnesium simple substance and chloroform, and then carrying out electrostatic spinning to obtain magnesium-based microspheres; and mixing the magnesium-based microspheres and the phosphate buffer solution and stirring to obtain the hydrogen slow-release solution. The magnesium simple substance is successfully wrapped in the L-polylactic acid by the electrostatic spinning technology, so that magnesium atoms can be effectively prevented from directly contacting with air or solution, magnesium particles are gradually released along with the decomposition of the L-polylactic acid in a liquid environment, and then the hydrogen which reacts to generate a therapeutic effect is effectively and slowly released. The preparation method provided by the invention has mature process, can effectively obtain a finished product, and is convenient for large-scale preparation.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to cosmetics. An anhydrous antiperspirant or deodorant composition contains an antiperspirant active substance, a water-immiscible liquid-carrier, a gelling agent, a layering inhibitor. The layering of the antiperspirant active substance suspended in the anhydrous compositions containing essences or non-volatile silicone fluids with a minimum refractive index 1.5, preferentially with a fatty alcohol, jellified with using a fibre-forming amide gelling agent, can be eliminated by the layering inhibitor, especially arylene-alkylene block polymer, such as triblock polymer, e.g. styrene/ethylene-butylene/styrene copolymer or styrene/butylene copolymer. ^ EFFECT: invention provides production of sticks with reduced layering between the top and bottom of an antiperspirant stick. ^ 52 cl, 3 tbl, 3 ex
Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations1,2, an alternative solution leverages irreversible genetic changes, such as naturally occurring mutations, to create indelible marks that enables retrospective temporal ordering3-5. Using a multipurpose, single-cell CRISPR platform, we developed a molecular clock approach to record the timing of cellular events and clonality in vivo, with incorporation of cell state and lineage information. Using this approach, we uncovered precise timing of tissue-specific cell expansion during mouse embryonic development, unconventional developmental relationships between cell types and new epithelial progenitor states by their unique genetic histories. Analysis of mouse adenomas, coupled to multiomic and single-cell profiling of human precancers, with clonal analysis of 418 human polyps, demonstrated the occurrence of polyclonal initiation in 15-30% of colonic precancers, showing their origins from multiple normal founders. Our study presents a multimodal framework that lays the foundation for in vivo recording, integrating synthetic or natural indelible genetic changes with single-cell analyses, to explore the origins and timing of development and tumorigenesis in mammalian systems.
Participants in the BAU group will be offered 10 caregiver support sessions after completing the 12-month follow-up. These home-based sessions will emphasize shared book reading, modeling vocabulary for school readiness in play and routines, and include general information for families about options for public school language related services. Each session will last about 30 minutes and be conducted by a trained staff member. Caregivers and children will be assessed at baseline, after the intervention, 6 months after intervention, and 12 months after intervention, and will receive a $50 gift card for participating in each assessment time point, $75 for completing all four assessments, and books and play/activity materials with target word lists in Spanish.
A standard diagnostic blood smear from a drop of blood will be carried out on 20 study subjects once per month. One malaria-positive subject from among the 20 will be asked to donate 5cc of blood, also no more frequently than once per month. The blood will be placed in a water-jacketed heated membrane feeding device that will be positioned on top of a cage of mosquitoes. The mosquitoes are attracted to the warmth and drink the blood through the artificial skin-like membrane. The goal of the research is to study the infected mosquitoes. No studies will be carried out on the human subjects. The point of human subjects involvement is to obtain the naturally malaria-infected blood for feeding of mosquitoes. After blood feeding, the mosquitoes are held in an environmental chamber for one week, at which time they are dissected to count numbers of malaria parasites developing on the mosquito stomach wall. This number constitutes the quantitative phenotype, and we extract genomic DNA from the carcass for genetic marker typing, which constitutes the genotype. Genetic linkage analysis identifies markers near genes that control parasite number, thus resistance or susceptibility to parasite infection.
Summary: Patients will be started on the study drug, lenalidomide on Day 1, Cycle 1. Lenalidomide is a capsule that is to be taken orally (by mouth). If the patient's disease progresses after 2 cycles of therapy, a low dose of dexamethasone will be added. If the patient's disease is stable after 2 cycles of therapy, the use of an alternate corticosteroid (prednisone) will be added to the lenalidomide therapy they are receiving. Dexamethasone and prednisone are in tablet form and will be taken orally (by mouth). However, if the patient has a minimal response after an additional 2 cycles of lenalidomide therapy, the therapy will be continued until their disease progresses. See the intervention descriptions for further details.
The invention discloses compound traditional Chinese medicine liquid for tooth washing. The compound traditional Chinese medicine liquid is prepared from lignum pini nodi, koelreuteria bipinnata roots, murraya alata drake, red psychotria leaves, roughhaired holly leaves, kidney fern, Chinese hibiscus, catharanthus roseus, marigold roots, hyptis suaveolens piot, hypericum sampsonii hance, narrowleaf screwtree roots, griffith streptocaulon roots, saussurea involucrata, mannitol, cellulase, taurine and arbutin. The compound traditional Chinese medicine liquid contains rich raw materials, a treating effect is fast, and the effective rate is up to 100%. The arbutin is purely and naturally extracted, is safe, healthy and free of toxic and side effects, the extraction rate is up to 23.7%, and the utilization rate is improved. All traditional Chinese medicines are subjected to extraction and purification for many times, the yield is increased by 14.8%, and much production cost is saved. The compound traditional Chinese medicine liquid has a faint scent and slight-sweet taste, is free of traditional Chinese medicine smell, does not make patients have rejection feeling, is simple to use and can inhibit hemodia, relieve aching and limp feeling, pain and bleeding symptoms during tooth washing, alleviate the tooth washing fear of the patients, inhibit bacteria, diminish inflammations, prevent infection and relieve decayed teeth, and the problem of clinical tooth washing is solved.
The present invention relates to a bed escape warning device for a dementia patient, and more specifically, to a bed escape warning device for a dementia patient capable of restricting movement of the dementia patient by providing a warning sound or informing a protector in advance when the dementia patient wants to get out of bed. When the dementia patient escapes from a bed, the bed escape warning device for a dementia patient prevents falling of the dementia patient and getting out of bed by ringing an alarm. The bed escape warning device for a dementia patient comprises: a fixing plate; a rotating plate; a sensor unit; a warning unit; and a hinge unit. The fixing plate is attached to a lower surface of the bed. The rotating plate is connected to the fixing plate, protrudes from the lower surface of the bed, and is rotated to a lower side when the dementia patient steps by feet. The sensor unit is mounted on the rotating plate to be close to the fixing plate. The warning unit is installed on the fixing plate to face the sensor unit, and rings the alarm when the rotating plate is rotated to the lower side by the feet of the dementia patient. The hinge unit is connected to the fixing plate to rotate the rotating plate.
Docetaxel (DTX) is a key drug used in perioperative chemotherapy for breast cancer. Edema is a known adverse effect of DTX, but its effect on health-related QOL (HRQOL) is unclear. In this study, we evaluated the effects of edema caused by administration of DTX on HRQOL in patients with early-stage breast cancer. We prospectively investigated patients diagnosed with early-stage breast cancer (stage I-III) who received 4 cycles of DTX as preoperative or postoperative chemotherapy between September 2021 and December 2022 at Yamanashi Prefectural Central Hospital. The circumference of each extremity was measured at each administration of DTX, and limb edema was evaluated by Common Terminology Criteria for Adverse Events version 5.0. HRQOL was evaluated using SF-12 version 2, which has a range of 0-100 (national standard, 50), and compared between the presence and absence of grade 2 or higher edema and between before and after administration of DTX. Twenty patients met the eligibility criteria and were included in the study. There was no difference in the HRQOL score according to whether grade 2 limb edema was present. The median HRQOL summary scores before and after administration of DTX were 51.1 and 50.8 (p=0.763), respectively, for mental health, 52.6 and 49.4 (p=0.005) for physical health, and 38.9 and 37.5 (p=1.000) for role/social health. We found no direct effect of DTX-induced limb edema on HRQOL in patients with early-stage breast cancer. However, HRQOL summary scores indicated that administration of DTX reduced physical health in these patients.
Certain carbocyanine compounds target mitochondria and may be used for eradicating cancer stem cells (CSCs). For example, MitoTracker Deep Red (MTDR) is a non-toxic, carbocyanine-based, far-red, fluorescent probe that is routinely used to chemically mark and visualize mitochondria in living cells. MTDR inhibits 3D mammosphere formation in MCF7 cells, MDA-MB-231 cells, and MDA-MB-468 cells, with an 1C-50 between 50 to 100 nM. Also, MTDR exhibited near complete inhibition of mitochondrial oxygen consumption rates and ATP production, in all three breast cancer cell lines tested, at a level of 500 nM. Nano-molar concentrations of MTDR can be used to specifically target and eradicate CSCs, by selectively interfering with mitochondrial metabolism. Other carbocyanine compounds having anti-CSC activity are described.
Pheochromocytomas are rare neuroendocrine tumors characterised by the secretion of catecholamines and their metabolites. While some patients may be asymptomatic, they can also present with various symptoms including hypertensive crisis, headaches, palpitations, diaphoresis or other signs of catecholamine toxicity. Adrenal haemorrhage, though rare, is a potentially fatal complication that is often diagnosed during autopsy. In all patients with suspected pheochromocytoma, regardless of whether haemorrhagic conversion has occurred, prompt diagnosis is imperative. Early identification allows for the timely initiation of treatment, preventing potentially life-threatening complications. This case report details the haemorrhagic conversion of an undiagnosed pheochromocytoma in a female patient in her 30s.
Patients referred for cardiac catheterization for diagnostic and/or treatment purposes will undergo a screening angiogram to assess eligibility. Eligible patients will be those with at least one major epicardial vessel having a lesion of 40-90% diameter stenosis per visual assessment of angiogram.
PURPOSE: To obtain the subject new treating agent, preventing an infection and bringing the burn into contact into a state capable of performing a skin transgrafting by containing a propolis and extracts of specific plant and animal for drying the skin damaged by the burn and a hemostatic tissue, and promoting a necrosis thereof. CONSTITUTION: This treating agent for a burn contains (A) 2-15 pt.wt. propolis with (B) 85-97 pt.wt. extracts of Scutellariae, Coptidis rhyzoma, Phellodedri cortex, Lumbricus (i.e., earthworm) and poppy seed shells extracted by a sesame oil, of which content of each extract is 2-10 pt.wt. of the medicine based on their dried materials, as active ingredients. Further, as the Scutellariae, the root of Scutellaria bai calensia Georgi belonging to Labiatae can be used and as Coptis rhyzoma, e.g. the root of Coptis chinensis Franch which is a plant of Ranunc-ulaceae can be used.
Participants in the comparison group will not receive the intervention during the study, but will be offered intervention once the study has been completed (i.e. 3 month waiting-period). However, in the event that a stressful situation arises while a participant is placed in the comparison group, the participant may seek assistance from the usual mental health supports offered through their respective occupational organizations, EAP programs, and other programs in the community. Following completion of the study, participants in the comparison group will be invited to attend the CBTm Course.
BACKGROUND: Hydatid cyst of the liver induced by Echinococcus granulosus is a pervasive zoonotic disease in our region. Its incidence varies across age groups, contingent on community lifespans and hygiene standards. Therapeutic modalities include Puncture, Aspiration, Injection, Re-aspiration (PAIR), and surgery. Due the limited feasability of PAIR, we suggest that surgery represents the optimal treatment in all stages, especially in endemic regions, depending on patient-specific variables.
METHOD: Patients with hydatid cyst of the liver treated with PAIR and surgery in our center between January 2016 and January 2022 were analyzed retrospectively. PAIR or cystectomy were applied in treatment. These were then compared in terms of efficacy, feasibility, and complications.
RESULTS: A single hydatid cyst of the liver was detected in 184 of the 225 cases, two cysts in 33, and three or more cysts in eight. The largest cyst diameter was 233 × 124 mm in the surgery group and 100 × 90 mm in the PAIR group. One hundred thirty-three of the 225 patients underwent open surgery, and no recurrence was encountered in these. However, recurrence was observed 19 patients treated with PAIR. Allergic reaction developed in one case during surgery, postoperative abscess in two cases, biliary fistula in five, and pneumonia in one.
CONCLUSION: Surgical treatment should represent the standard procedure since it is safe and effective, ensures complete elimination of the parasite, involves no intraoperative shedding, preserves healthy tissues, and minimizes the risk of long-term recurrence and cavity-related complications.
1318690 Cephalothin salts ELI LILLY & CO 20 Dec 1971 [24 Dec 1970] 59068/71 Heading C2A Alkali metal salts of 7-(2<SP>1</SP>-thienylacetamido) cephalosporanic acid (i.e. cephalothin) are recovered from aqueous solutions thereof by adding a non-toxic alkali metal salt to the solution to precipitate the cephalothin salt and separating the precipitate thus formed. Preferred alkali metal salts are those of an acid having a pKa of less than 5, e.g. alkali metal bromide, chloride, acetate, citrate, lactate, maleate, fumarate, gluconate and glutarate. The alkali metal (e.g. Na, K or Li) is preferably the same as the cation of the cephalothin salt. The alkali metal salt may be added in solid form or as a concentrated solution in water or an alkanol (e.g. ethanol, isopropanol or butanol), or a mixture thereof, and is employed in an amount ranging from 0À5-8À0 parts by weight per part of the cephalothin salt in the solution. The cephalothin salt solution is preferably fairly concentrated, e.g. from 10% by weight to saturation concentration. The process results in a purified cephalothin salt free from coloured impurities and having improved stability in aqueous solution. Pharmaceutical compositions having antibacterial activity comprise an alkali metal salt of cephalothin when prepared by the inventive process and a pharmaceutical carrier.