Coronaviruses (CoV) are a large family of RNA viruses that cause illnesses ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV).1,2 The new strain of coronavirus identified in December 2019 in Wuhan city, Hubei province of China, was called 2019 novel coronavirus (2019- nCoV) and has been named by the International Committee on Taxonomy of Viruses (ICTV) as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). The ICTV have determined that SARS-CoV-2 is the same species as SARS-CoV but a different strain. The World Health Organization (WHO) has named the disease associated with SARS-CoV-2 infections as "COVID-19".

Clinical features of SARS-CoV-2 infection typically include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, the infection can cause pneumonia, severe acute respiratory distress syndrome (ARDS), kidney failure and even death. It is not easy to differentiate between non-SARS-CoV-2 seasonal influenza and other respiratory viruses including the locally reported MERS-CoV and H1N1 influenza viruses. SARS-CoV-2 has a higher transmission rate (TR) with an approximate fatality rate of 3%. Although most of the younger patients recover after milder disease, but COVID-19 is most aggressive in the elderly population with worst pneumonia and death rates may reach 14.8%.4 Final diagnosis of SARS-CoV-2 infection depends on viral detection (and if possible, exclusion of other viruses e.g. by Respiratory Viral Panel). Laboratory detection of the SARS-CoV2 is based on detection of viral RNA by real-time reverse transcription-polymerase chain reaction (rRT-PCR) with confirmation by nucleic acid sequencing when necessary.1-5 For example, GeneFinder™ COVID-19 Plus RealAmp Kit is the One-Step Reverse Transcription Real-Time PCR Kit designed to detect the Novel Coronavirus (COVID-19) qualitatively through Reverse Transcription reaction and Real-Time Polymerase Chain Reaction. We will use this or equivalent method to confirm the diagnosis and will repeat the rRT-PCR to make sure it has become negative in a recovered patient. As of now, no vaccine or antiviral drug coming soon, antibodies from recovering patients could provide a "stop-gap" measure to help in controlling the pandemic. The concept of using convalescent plasma is not new. It has been tried in limited numbers of patients during more-recent viral crises, including the 2003 SARS (severe acute respiratory syndrome) epidemic, the 2009 "swine flu" epidemic, and the 2012 outbreak of MERS (Middle East respiratory syndrome).6 Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 Virus Infection.7 Patients with a resolved viral infection will develop a polyclonal antibody immune response to different viral antigens of 2019-nCoV. Some of these polyclonal antibodies will likely neutralize the virus and prevent new rounds of infection, and the patients with resolved infection should produce 2019-nCoV antibodies in high titer. Patients with resolved cases of 2019-nCoV can simply donate plasma, and then this plasma can be transfused into infected patients.8 Given that plasma donation is well established, and the transfusion of plasma is also routine medical care, this proposal does not need any new science or medical approvals in order to be put into place. Indeed, the same rationale was used in the treatment of several Ebola patients with convalescent serum during the outbreak in 2014-2015.9 Since the emergence of this SARS-CoV-2 infection in Wuhan, China, in December 2019, it has rapidly spread across China and more than 188 other countries and territories. According to the WHO, as of March 27, 2020, there have been 540,832 confirmed cases worldwide and 24,294 deaths. SARS-CoV-2 has structural similarity to SARS-CoV that caused SARS and MERS-CoV.3 In the Kingdom of Saudi Arabia, there are 1012 confirmed cases reported till now, with 3 deaths (on March 26, 2020).

The Saudi government's prompt actions to slow down the spread of SARS-CoV-2 seem to be effective. However, CDC Estimates 40-70% of the US population will be infected with SARS-CoV-2. Even with curtailment measures, judging from past pandemics, approximately 40% of human beings will be exposed to COVID-19 over the next 2-3 years. Most of these infected people will recover and almost all of them will be immune. Vigilance and readiness are needed to teach the masses about preventive measures because older people and those with comorbidities will be the sickest. Contemporaneously, therapeutic measures are highly needed from the medical community to treat COVID-19 patients.