anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to an aspirin slow-control-release micro pill and a preparing method thereof. The prescription mainly comprises aspirin, sucrose or lactose, starch, dextrin or microcrystalline cellulose, polyvidone or hypromellose, alcohol, Tween-80, acrylic resin and talcum powder. The present invention has the preparing method which comprises the following steps: treated main materials and adjuvant materials are proportionally mixed into mixed powder; a micro pill containing the medicine is made by a cutting and spraying granulation machine; a finished product is obtained by coating operation. The present invention reduces the producing cost of a micro pill preparation, and keeps all the advantages of the micro pill preparation. Meanwhile, the problem that the tail material in the production of the micro pill preparation can not be easily treated is excellently solved. Thus, the producing cost of the micro pill preparation is greatly reduced. Thus, the patients economic pressure can be greatly reduced. The present invention has good economical and social benefits.
BACKGROUND: Road trauma (RT) survivors have reduced health-related quality of life (HRQoL). We identified phases and predictors of HRQoL change following RT injury.
METHODS: In a prospective cohort study of 1480 Canadian RT survivors aged 16 to 103 years (July 2018 - March 2020), physical component (PCS) and mental component (MCS) summary scores from the SF-12v2 were measured pre-injury and 2, 4, 6, and 12 months post-injury and their trajectories were analyzed with piecewise latent growth curve modeling. Potential predictors of HRQoL changes included sociodemographic, psychological, medical, and trauma-related factors.
RESULTS: PCS and MCS scores worsened from pre-injury to 2-months (phase 1) and then improved (phase 2), but never regained baseline values. Older age, somatic symptoms and pain catastrophizing were associated with lower preinjury PCS and MCS scores. Psychological distress was associated with lower preinjury MCS scores and higher preinjury PCS scores. Phase 1 PCS scores decreased most in females, participants with fewer pre-injury somatic symptoms and those without expectations for fast recovery. Phase 1 MCS decreases were associated with younger age, female sex, living alone, lower psychological distress, lack of expectation for fast recovery and higher injury pain. In phase 2, MCS improved most in participants not using recreational drugs; PCS improved most in participants with higher education and longer recovery expectations.
LIMITATIONS: There may be recall bias with reporting pre-injury HRQoL. Selection bias is possible.
CONCLUSIONS: Many factors influence HRQoL following RT. These findings may inform measures to minimize HRQoL reduction following RT and speed up subsequent recovery.
BACKGROUND & AIMS: Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids into monounsaturated fatty acids and plays an important regulatory role in lipid metabolism. Previous studies have demonstrated that mice deficient in SCD1 are protected from diet-induced obesity and hepatic steatosis due to altered lipid assimilation and increased energy expenditure. Previous studies in our lab have shown that intestinal SCD1 modulates intestinal and plasma lipids and alters cholesterol metabolism. Here, we investigated a novel role for intestinal SCD1 in the regulation of systemic energy balance.
METHODS: To interrogate the role of intestinal SCD1 in modulating whole body metabolism, intestine-specific Scd1 knockout (iKO) mice were maintained on standard chow diet or challenged with a high-fat diet (HFD). Studies included analyses of bile acid content and composition, and metabolic phenotyping, including body composition, indirect calorimetry, glucose tolerance analyses, quantification of the composition of the gut microbiome, and assessment of bile acid signaling pathways.
RESULTS: iKO mice displayed elevated plasma and hepatic bile acid content and decreased fecal bile acid excretion, associated with increased expression of the ileal bile acid uptake transporter, Asbt. In addition, the alpha and beta diversity of the gut microbiome was reduced in iKO mice, with several alterations in microbe species being associated with the observed increases in plasma bile acids. These increases in plasma bile acids were associated with increased expression of TGR5 targets, including Dio2 in brown adipose tissue and elevated plasma glucagon-like peptide-1 levels. Upon HFD challenge, iKO mice had reduced metabolic efficiency apparent through decreased weight gain despite higher food intake. Concomitantly, energy expenditure was increased, and glucose tolerance was improved in HFD-fed iKO mice.
CONCLUSIONS: Our results indicate that deletion of intestinal SCD1 has significant impacts on bile acid homeostasis and whole-body energy balance, likely via activation of TGR5.
Refractory hypoxemia (RH) during venovenous extracorporeal membrane oxygenation (VV ECMO) support is a complex problem that limits the benefit of this therapy. The need for sustained deep sedation and delays in active rehabilitation are considered as a direct consequence of RH. Changing from VV ECMO to a configuration that returns the flow to pulmonary artery, such as venopulmonary extracorporeal membrane oxygenation (VPa ECMO) may decrease recirculation and improve systemic oxygen delivery. We present a retrospective report that describes the impact of VPa ECMO on oxygenation during sedation withdrawal in 41 patients who received VV ECMO for coronavirus disease 2019 (COVID-19). We evidenced that arterial oxygen pressure (PaO 2 ) increased from 68 to 112.3 mm Hg ( p = 0.001) with a reduction of ECMO flow (5.7-4.8 L/m; p = 0.001). Other findings included lower rates of depth sedation (Richmond Agitation Sedation Scale [RASS] ≤3, 37-63%; p = 0.007) and lower requirement inotropic support assessed by LVIS score (4.7-1.1; p = 0.005). Discharge survival was 54% with a sustained benefit until day 79. This cannulation strategy improved effectively PaO 2 in this cohort, it may be an alternative in patients with RH in VV ECMO.
The present invention relates to a device and to a method for comparing and evaluating a treatment plan received from heterogeneous radiation treatment devices. A device for evaluating a radiation treatment plan according to an embodiment of the present invention includes a receiving means, a processing means, and a display means. The receiving means receives a medical image of a patient, which is generated by a medical image capturing device. The receiving means receives the patient's first radiation treatment plan data, which is generated by a first radiation treatment device, and also receives the patient's second radiation treatment plan data, which is generated by a second radiation treatment device. The processing means processes the first and second radiation treatment planning data to generate mixed data overlaid onto the medical image of the patient. The display means displays the mixed data generated by the processing means. According to a configuration of the present invention, trial and error during radiation treatment may be minimized. Thus, the quality of the treatment plan may be maximized.
Esophageal cancer is common worldwide, with ESCC being the most frequent tumor in East Asia. Tumor-associated macrophages are an important component of the ESCC microenvironment. SUMOylation is a post-translational modification of proteins, and SUMO-specific proteases (SENPs) play an important role in de-SUMOylation. In human patients, we discovered that the levels of SENP3 were upregulated in the tumor-associated macrophages. Furthermore, the loss of SENP3 enhanced the alternative activation of macrophages in the 4-NQO-induced ESCC mice model. This is the first study to identify SENP3-mediated macrophage polarization via the de-SUMOylation of interferon regulatory factor 4 (IRF4) at the K349 site. Alternative activation of macrophages increases the migration and invasion potential of ESCC cells and promotes their progression in vivo. Moreover, patients with relatively low SENP3 expression in macrophages exhibit higher primary PET SUVmax value and lymph node metastasis rates. In summary, this study revealed that SENP3-mediated IRF4 de-SUMOylation is crucial for the alternative activation of macrophages and influences the progression of ESCC.
Blinded treatment with placebo, one pill a day. If after the 4 weeks, the patient has not remitted, they will be increased to 2 pills a day.
The invention belongs to a medicine composition used for turning white hair into black and particularly relates to a composite medicament used for turning white hair into black and a preparation method thereof. The composite medicament comprises external application medicine for smearing and internal application medicine for decoction. The external application medicine comprises the effective components including radix angelica sinensis, polygonum multiflorum, rhizoma drynariae, flos carthami, cacumen biotae, ligustrum lucidum ait, dried radix rehmanniae, radix angelicae, mulberry, herba ecliptae, lithospermum, divaricate saposhnikovia root, capsicum annuum, radix aconite, rhizoma atractylodis, licorice root, radix rehmanniae preparata, poria cocos, Chinese yam, fennel, semen cuscutae, cortex moutan, cortex albiziae, mulberry leaves and polygonatum kingianum. The internal application medicine comprises the effective components including poria cocos, Chinese yam, fennel, semen cuscutae, cortex moutan, cortex albiziae, mulberry leaves and polygonatum kingianum. The external application medicine enters a body by means of permeability of skin and has the effects of dredging joint orifices, nourishing blood and blackening hair, beautifying face and smoothening skin, promoting metabolism and regulating qi, blood and viscera. By means of the internal application medicine, the kidney function of the human body is further improved, kidney yin is complemented for, the human body is regulated fundamentally, and the white hair problem is completely solved.
This application discloses a method, device, and computer readable storage for training disease discrimination model. The method includes establishing a disease discrimination model, the disease discrimination model includes a convolutional neural network and a pyramid attention mechanism. The pyramid attention mechanism sets on the output end of the convolutional neural network. Obtaining a feature image sample set, and divide the feature image sample set into a training set and a verification set. Inputting the training set into the disease discrimination model to train the disease discrimination model according to the training set, and output a disease confidence likelihood value. Verifying the disease discrimination model according to the verification set. The trained disease discrimination model is suitable for different medical image and has a high recognition rate.
A detailed evaluation is of great importance in the correct diagnosis and treatment of patients with LUTD. In order for a holistic evaluation to show the right path, history taking and physical examination are the most important steps of the evaluation. In addition, it is recommended by ICCS to observe and question the conditions that may cause urgency, holding maneuvers and behavioral structure of the patient. In current clinical practice, changes in posture and balance have been noticed during physiotherapy assessments in children and adolescents with incontinence. In addition, we think that it is possible to disrupt the trunk and lower extremity alignments, which are frequently performed by children with incontinence. These changes may be an important part of the physical and developmental disturbances in children with incontinence. The pelvis and lower extremity consist of interconnected closed chain structures. The movement of any link in the chain depends on the movement and positions of the other links. Therefore, disruption of the alignment of one of the links forming and affecting the chain may cause a change in the mobility and stability of all mechanically related structures, and may also affect the optimal force and activation that the pelvic floor muscles can produce. Our study hypothesizes that the movement of any link in the closed chain of the body and the disruption of one of the links forming this chain cause a change in the mobility, stability and balance of all structures that are mechanically connected, this change will closely affect the activation of the pelvic floor muscles, as well as the children in this group. It was stated that the trunk and lower extremity alignment might have been impaired due to the holding maneuvers that he frequently performed.

Our study, it was aimed to examine the trunk and lower extremity biomechanics in children with LUTD. In addition, if biomechanical changes are detected in the trunk and lower extremities of children and adolescents with incontinence, our study will lead to the necessity of including these changes in the treatment.
Opioids can be used for medical and non-medical purposes. Chronic pain such as cancer, as well as the frequent use of such drugs in places such as operating rooms and intensive care units, and in non-medical areas like drug abuse the effects and side effects of these drugs need to be examined in more detail. For this purpose, the effects of fentanyl and remifentanil drugs on neuroinflammation, oxidative stress and cholinesterase metabolism were investigated. Neuron cells (CRL-10742) were used for the evaluation of the toxicity of fentanyl and remifentanil. MTT, PON1 activity and total thiol levels for its effect on oxidative stress, AChE and BChE activities for its effect on the cholinergic system, and TNF, IL-8 and IL-10 gene levels for its neuroinflammation effect were determined. The highest neurotoxic dose of fentanyl and remifentanil was determined as 10 μg/mL. It was observed that the rate of neuron cells in this dose has decreased by up to 61.80% and 56.89%, respectively. The IL-8 gene expression level in both opioids was down-regulated while IL 10 gene level was up-regulated in a dose-dependent manner compared to the control. In our results, the TNF gene expression level differs between the two opioids. In the fentanyl group, it was seen to be up-regulated in a dose-dependent manner compared to the control. Fentanyl and remifentanil showed an inhibitory effect against PON1, while remifentanil showed an increase in total thiol levels. PON1, BChE and total thiol activities showed similarity with MTT.
Participants will use a sham device twice per day for 16 minutes per day for 8 weeks. They will be assessed for symptoms of depression at baseline, along with symptoms every two weeks thereafter until the 8 week mark. Participants will also be assessed for anxiety, irritability, future orientation, quality of life, and rumination.
A composition for alleviating hangover symptoms in a subject in need thereof. The composition comprises dihydromyricetin, N-Acetyl Cysteine, taurine, salicin, niacin, vitamin B6, selenium, manganese and prickly pear powder. The composition can be formulated as pills or capsules. The dihydromyricetin component may be coated with soy lecithin to maximize absorption. The composition includes a first composition and a separate second composition. The composition is administered as a first pill or capsule comprising the first composition prior to alcohol consumption and a second pill comprising the first composition taken after alcohol consumption.
The invention relates to a traditional Chinese medicine for treatment of uterine leiomyoma. The traditional Chinese medicine consists of the following Chinese medicinal raw materials by weight: 5-10g of Savia miltiorrhiza, 10-15g of concha arcae, 5-10g of prunella vulgaris, 3-9g of fiveleaf akebia fruit, 3-6g of Sparganium stoloniferum, 5-9g of Kadsura coccinea root, 3-6g of Euonymus fortune, 3-6g of Caulopyhllum robustum, 3-5g of Antigramma sibiricus, 5-8g of cinnamon, 3-9g of asarum, 5-12g of dried ginger, 5-10g of lotus leaf, and 3-6g of Stellaria media. The concha arcae, prunella vulgaris and fiveleaf akebia fruit can soften hardness to dissipate stagnation. The Savia miltiorrhiza, Kadsura coccinea root, Euonymus fortune and Caulopyhllum robustum can regulate qi and activate blood circulation. The cinnamon, as arum and dried ginger can warm channel to dispel cold. The lotus leaf, Stellaria media, Sparganium stoloniferum and Antigramma sibiricus can disperse blood stasis and remove symptoms. Combination of all the drugs can achieve an exact curative effect on uterine leiomyoma and a high cure rate, makes the diseases difficult to recur, and has no toxic or side effect.
The Vesical Imaging-Reporting and Data System (VI-RADS) is a standard magnetic resonance imaging (MRI) and diagnostic method for muscle-invasive bladder cancer that was published in 2018. Several studies have demonstrated that VI-RADS has high diagnostic power and reproducibility. However, reading VI-RADS requires a certain amount of expertise, and radiologists need to be aware of the various pitfalls. MRI of the bladder includes T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced imaging (DCEI). T2WI is excellent for understanding anatomy. DWI and DCEI show high contrast between the tumor and normal anatomical structures and are suitable for staging local tumors. Bladder tumors are classified into five categories according to their size and morphology and their positional relationship to the bladder wall based on the VI-RADS diagnostic criteria. If the T2WI, DWI, and DCEI categories are the same, the category is the VI-RADS category. If the categories do not match, the DWI category is the VI-RADS category. If image quality of DWI is not evaluable, the DCEI category is the final category. In many cases, DWI is dominant, but this does not mean that T2WI and DCEI can be omitted from the reading of the bladder. In this educational review, typical and atypical teaching cases are demonstrated, and how to resolve misdiagnosis and the limitations of VI-RADS are discussed. The most important aspect of VI-RADS reading is to practice multiparametric reading with a solid understanding of the characteristics and role of each sequence and an awareness of the various pitfalls.
We will be confirming that the patients are HIV positive and has antibodies to either HSV 1 or HSV 2 as part of the screening process. If so, we will then obtain patient baseline HIV-PCR, CD4, medial history including medications on day one. Whether the patient is on any or no herpes controlling medication. If the patient has what they feel is a flare up of HSV, they will come into clinic where the lesion will be culture and the patient's HIV-PCR and CD4 will also be obtained. Otherwise, the patient will receive phone follow ups every three months to see if there has been and change in their health or medications. The main endpoint is to see if there is a correlation between outbreaks in HIV patients and their CD4 cells and/or HIV and/or Herpes medication.
The invention relates to methods and compositions for the diagnosis and treatment of metabolic disorders, including, but not limited to, obesity, overweight, diabetes, insulin resistance, anorexia, and cachexia. The invention further provides methods for identifying a compound capable of treating a metabolic disorder. The invention also provides methods for identifying a compound capable of modulating a metabolic activity. Yet further, the invention provides a method for modulating a metabolic activity. In addition, the invention provides a method for treating a subject having a metabolic disorder characterized by aberrant MMP-12 polypeptide activity or aberrant MMP-12 nucleic acid expression. In another aspect, the invention provides methods for modulating lipogenesis in a subject and methods for modulating lipolysis in a subject.
Participants in this arm complete an initial introductory session of the sham training control condition in the lab followed by 6 sessions scheduled to be completed over the subsequent week (1 per day). CBM-I will be administered via an online platform using an individual login account.
Composition and methods are described for low immunogenic protein formulations. An example of such a protein is antihemophilic factor (FVIII). The composition generally includes the protein, polypeptide or peptide, one or more agents that bind to epitope domains of the proteins to form a complex. Buffers containing salts may be used to stabilize this interaction. For example, Factor VIII and serine containing phospholipids in buffer salts containing Ca 2+  and Na +  can be used to prepare protein-lipid structures. These complexes are useful for treatment of diseases such as Hemophilia. A method for the formation of novel non-liposomal structures is also disclosed.
This study will use the Delphi process to conduct this study. This survey research involves Phase 1 and Phase 2 of questioning, each phase involves up to 3 rounds of questions to determine agreement or disagreement. Each round will take approximately 20 minutes to complete, and responses will remain completely confidential. For both phases, the questions will either be 7-point Likert or multiple choices. For both phases, the group of questions will be sent up to three times until agreement (up to 80% of agreement consensus). Questions that have obtained agreement will be removed in each round. The questions will help the experts and the research team understand where there is current agreement on, or topic that may need to be discussed/studied further to unify trainings.
The invention belongs to the technical field of gene therapy, and particularly relates to amino lipid and a preparation method and application thereof. The compound with the structure of the formula (I) can be used for preparing a composite carrier together with other auxiliary lipids to deliver medicaments, including nucleic acid medicaments, protein medicaments, small molecule medicaments and the like. The reaction condition is mild in the process of constructing the amino lipid, protection and deprotection are not needed, and the atom economy is high. In vitro and in vivo delivery studies, an excellent ability to deliver nucleic acids into cells was demonstrated. The two ester bonds introduced by the amino lipid compound obviously enhance the degradation capability of the amino lipid and greatly reduce the cytotoxicity. The preparation method of the amino lipid compound has the advantages of easily available raw materials, mild reaction conditions, good reaction selectivity, high reaction yield, low requirements on instruments and equipment and simple operation.