anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Screening for colorectal cancer (CRC) remains severely underutilized. Although simple reminders are modestly effective in enhancing preventive care utilization, they are not widely utilized. Even if used widely, the effectiveness of simple reminders is limited, leaving nearly half of patients without screening. One explanation for this is that simple reminders do not address the barriers and resources of the patients and physicians they are designed to prompt. In this study, we will examine the impact on CRC screening of a reminder system that uses the physician as the message source and is tailored to the physician screening preferences and patient-reported characteristics, CRC screening-related barriers, status and CRC susceptibility. This intervention will be compared to a standard CRC health education and screening reminder system.

Touch screen 'Healthy Living' computer kiosks will be placed in 16 Kansas Physicians Engaged in Prevention Research (KPEPR) Network primary care practices. The kiosk program will screen for eligible participants who are at least 50 years of age and not up-to-date with CRC screening and guide eligible participants through a computerized Colorectal Cancer Assessment (CRCA). Kiosk participants will be randomized into either a general CRC health education + screening reminder message (GRM) (N=640) or a patient and physician-tailored CRC + screening reminder message (TRM) (N=640). Immediately upon completion of the CRCA, GRM participants will receive a brief informational flyer with general CRC health education messages and a reminder to get screened routinely for CRC. Participants in the TRM arm will receive an informational flyer that contains messages that are tailored to patient CRC screening barriers, preferences, and attitudes and physician screening preferences (guided by CRC screening options that are available within the local community) in addition to a reminder to get screened for CRC. A 90-day telephone follow-up will assess participant compliance with CRC screening recommendations, participant discussion with their physician regarding CRC screening, and patient satisfaction.

This study will use a novel patient- and physician- tailored messaging approach to promote colorectal cancer screening utilization. This study will help to assess how a practice-based computerized patient activation approach can effectively circumvent the "systems problems" endemic in rural primary care and lay the groundwork for future computer-based primary care intervention studies to help patients make informed health decisions and engage in healthy lifestyle behaviors.
A system of aqueous nail polish compositions is provided, including base coat, color coat, and top coat formulations. The base coat formulation comprises aqueous emulsions of acrylic polymer and vinyl acetate/acrylic copolymer. The color coat formulation comprises an aqueous solution of polyurethane resin and a colorant in addition to aqueous emulsions of acrylic polymer and vinyl acetate/acrylic polymer. Finally, the top coat formulation comprises an aqueous emulsion of vinyl acetate/acrylic polymer and an aqueous solution of polyurethane resin. The aqueous nail polish formulations of the present invention are substantially non-flammable and non-toxic while providing comparable nail coverage, wearability, and stability to non-aqueous nail polishes. Further, the present formulations offer rapid dry times and may be readily applied to nails using conventional nylon brushes.
Patients randomly assigned to receive SME+Karie will 1) undergo Screening for Self Medication Readiness to determine self-management capacity, 2) will receive self-medication education (SME) by a study Occupational Therapist, and 3) receive a 5-day self-medication performance assessment by an Registered Nurse prior to discharge. In addition, this group will receive orientation to the Karie Automated Medication Delivery by the study Occupational Therapist. The participants in the intervention arm will use the Karie device for all applicable medications for the study duration.
The prevention of Type 2 diabetes in an obese person with prediabetes requires developing a healthier lifestyle. The rational approach for someone with prediabetes would be to eat healthier, be more active, lose weight, and manage their comorbidities. However, preliminary research suggests that individuals with Type 2 diabetes discount the future and engage in behaviors that maximize current pleasure and short-term gain; thus, daily choices needed to improve future health are rare in this population. Delay discounting (DD) describes the choice of smaller immediate versus larger delayed rewards. This behavioral process is related to a wide variety of health choices, ranging from preventive health to behavioral and medical regimen adherence, including regimens used for Type 2 diabetes. The investigators believe that DD provides a target for one type of self-regulation that can improve a wide variety of health behaviors and medical adherence.

Research from our laboratories has shown that episodic future thinking (EFT), a form of prospection which reduces the bias towards immediate gratification, activates brain regions involved in planning and prospection such that future rewards have increased value and the extent of delay discounting is reduced. Cueing individuals to think about future events during inter-temporal decision-making reduces the rate of DD, eating in and outside of the laboratory, and smoking behavior. The overarching goal of this research is to use an experimental medicine approach to translate basic research on DD and EFT into clinical interventions to prevent the transition from prediabetes to a diagnosis of Type 2 diabetes.
OBJECTIVES: This study aims to investigate the impact of mesenchymal stem cell (MSC)-derived exosomes (Exo) on cerebral ischemia and reperfusion (I/R) injury, along with the underlying mechanism.
METHODS: An animal model of cerebral ischemia was induced using middle cerebral artery occlusion (MCAO), and a cell model utilizing Neuro-2a cells was established through oxygen-glucose deprivation/reoxygenation (OGD/R). Exosomes isolated from mouse MSCs were administered to mice or used to stimulate Neuro-2a cells. Exosomes from MSCs transfected with miR-NC, miR-486-5p mimics, miR-486-5p inhibitor, or phosphatase and tensin homolog (PTEN) short hairpin RNAs (sh-PTEN) were employed to stimulate Neuro-2a cells. The regulatory axis of miR-486-5p and PTEN was confirmed through rescue experiments.
RESULTS: Exo-miR-486-5p mimics alleviated cerebral I/R injury, improving neurological deficits and reducing the infarct ratio. Furthermore, Exo-miR-486-5p mimics attenuated OGD/R-induced defects in cell viability and inhibited apoptosis in Neuro-2a cells. These mimics also reduced levels of lactate dehydrogenase (LDH) and malondialdehyde (MDA) while enhancing superoxide dismutase (SOD) activity, both in brain tissue homogenates of mice and cell supernatants. Mechanistically, PTEN was identified as a target of miR-486-5p, and the downregulation of PTEN notably elevated Exo-miR-486-inhibitor-induced reductions in cell viability while mitigating cell apoptosis.
CONCLUSION: The results of this study demonstrate the potential of exosomes derived from MSCs to protect against cerebral I/R injury via the miR-486-5p and PTEN axis.
PURPOSE: An obesity suppressing composition which contains an extract of Theae folium and Oenothera odorata Jacq. and effectively inhibits a fatty acid synthase(FAS) gene mutation is provided. The prepared composition is harmless to a human body and can be effectively used in treatment and prevention of various diseases related with obesity. CONSTITUTION: The obesity suppressing composition contains 2 to 3g of Theae folium and 5 to 6g of Oenothera odorata Jacq. in a weight ratio of 1:1 to 2, on a dry basis. For an example, 2g of Theae folium is extracted in 100ml distilled water for 10min, filtered and concentrated under reduced pressure. And 5g of Oenothera odorata Jacq. is refluxed in 100ml distilled water at 25deg.C for 2hr, filtered and concentrated under reduced pressure.
The mechanisms of central neuropathic pain (CNP) caused by spinal cord injury have not been sufficiently studied. We have found that the upregulation of astrocytic aquaporin-4 (AQP4) aggravated peripheral neuropathic pain after spinal nerve ligation in rats. Using a T13 spinal cord hemisection model, we showed that spinal AQP4 was markedly upregulated after SCI and mainly expressed in astrocytes in the spinal dorsal horn (SDH). Inhibition of AQP4 with TGN020 suppressed astrocyte activation, attenuated the development and maintenance of below-level CNP and promoted motor function recovery in vivo. In primary astrocyte cultures, TGN020 also changed cell morphology, diminished cell proliferation and suppressed astrocyte activation. Moreover, T13 spinal cord hemisection induced cell-surface abundance of the AQP4 channel and perivascular localization in the SDH. Targeted inhibition of AQP4 subcellular localization with trifluoperazine effectively diminished astrocyte activation in vitro and further ablated astrocyte activation, attenuated the development and maintenance of below-level CNP, and accelerated functional recovery in vivo. Together, these results provide mechanistic insights into the roles of AQP4 in the development and maintenance of below-level CNP. Intervening with AQP4, including targeting AQP4 subcellular localization, might emerge as a promising agent to prevent chronic CNP after SCI.
OBJECTIVE: The present study aimed to explore the effects of sleep deprivation on young novice drivers' cognitive neural processing of different hazard types.
METHOD: A 2 (sleep deprivation group, control group) × 3 (no hazard, covert hazard, overt hazard) mixed experimental design was used. Twenty-eight young drivers were sleep-deprived (no sleep within the past 24 h), while 28 drivers were in the control group (maintaining a normal schedule throughout the week). Eighty pictures containing a covert hazard (20 pictures), overt hazard (20 pictures) and no hazard (40 pictures) were presented. Participants were asked to press the keyboard quickly if they detected a hazard situation. The reaction time, accuracy, and changes in the N1 (100-150 ms) and N2 (250-350 ms) components of event-related potentials (ERP) measured using electroencephalography (EEG) were obtained.
RESULTS: Compared to the control group, the response accuracy of sleep-deprived drivers was higher in the cover-hazard situation and their N1 latency was longer in the no-hazard situation. Compared to the no-hazard and overt-hazard situations, the participants' reaction times and N2 amplitudes were significantly greater, and the response accuracy was significantly lower in the covert-hazard situation.
CONCLUSION: Hazard perception is compromised when drivers are sleep-deprived, especially when they are confronted with covert hazard situations. The findings help understand the negative effects of sleep deprivation in the early stage of young novice drivers' hazard perception.
Pediatric migraine headache is a common cause of severe recurring headaches in children, especially children between the ages of 5 and 15 years. These headaches can be disabling and tend to interfere with a child's daily activities, such as going to school or playing with friends. Because pediatric migraine children tend to be misdiagnosed, they are often not treated effectively. Topiramate, an anti-seizure medication, has been shown to prevent migraines in adults, and it has been approved to treat seizures in children as young as 2 years of age as add-on treatment (used with another drug) and also can be used alone (monotherapy) in children as young as 10 years old. Since topiramate has already been studied in children, information about its safety in children is available. In this study, children with migraine headaches will be identified. It is not necessary for the child to have the migraine aura (having blurry vision; seeing flashing lights) to be included in this study. This is a randomized, double-blind, placebo-controlled study of Topiramate (or placebo) given for 4 to 5 months. An optional 3-month open-label extension (topiramate only; no placebo) will follow. The objective of the study is to demonstrate that topiramate is effective and safe when used to prevent migraine headaches (with or without aura) in children. Safety will be assessed throughout the study.

Topiramate sprinkle capsules (or placebo), starting at 15 milligrams per day for 1st week; increased to 30 milligrams per day for week 2; increased to 50 milligrams (in tablets) per day in week 3, then adjusted as needed to 2 to 3 milligrams/kilogram/day for the rest of study (140 days total).
The invention relates to the field of medicine. Curcumalactone derivatives with antitumor activity and the process for their preparation are disclosed. The said curcumalactone derivatives and their oxidized derivatives have a spironolactone structure as in formula (I). The preparation process for these compounds are also provided, wherein biotransformation is used. The intermediates of the process as in formula (II) are disclosed. The present compounds have antitumor activity.
PROBLEM TO BE SOLVED: To release acetic acid by a controlled method when a occlusive dressing for wounds having a cellulose ester base and partial solvent is exposed to a body temp. and moisture by forming the base of this bandage of a knit fabric and have the acetic acid released by the hydrolysis of the cellulose ester base at a specific temp. SOLUTION: The base of the divesting for wounds having the cellulose ester base and the partial solvent is formed of the knit fabric and the acetic acid is released by the hydrolysis of the cellulose ester at 98.6±5 deg.F with the controlled method. The partial solvent is selected from a group consisting of glycerol triacetate, trimethylne glycol diacetate, glycol acetate monoethylene and their combination. Further, the partial solvent is formed of the glycerol triacetate. The bandage is so formed as to release the acetic acid exceeding 1000 microgram/day and the cellulose ester is formed of the cellulose acetate having a degree of substitution of about 2.5/anhydroplucose unit.
A method may include collecting sensor data related to a quality of health of a patient. The method may include receiving patient input in response to a minimum number of questions for high statistical measurement of three health dimensions of the patient. The method may include generating a health score for each of three health dimensions of the patient. The method may include categorizing the health score for each of the three health dimensions. The method may include determining a minimum category of questions for high statistical measurement of each category of the three health dimensions. The method may include quantifying each of the three health dimensions of the patient per a VAS health score. The method may include generating a health risk score that is based on the health score for each of the three health dimensions. The method may include providing a health risk result to a care-provider.
Patients were randomly assigned to three groups, receiving TEAS 30min before anesthesia. The frequency of high frequency group is set to 10/50HZ, low frequency group is 2/10HZ, and the fake stimulation group only attach electrodes without electric current. Acupoint selection is bilateral Neiguan points(PC6). Venous blood is collected 4ml before and immediately after TEAS respectively. Heart rate variability is monitored continuously during the 30min TEAS. The adverse events recorded.
The current dietary reference intake (DRI) recommendations for protein in children (6-11 years old) and adults (\>19 years old) are based on nitrogen balance data and set at a mean (EAR) of 0.76 and 0.66 g/kg/day respectively and population safe (RDA) recommendation of 0.95 and 0.80 g/kg/day respectively. Using the indicator amino oxidation (IAAO) method we estimated higher protein requirements in these populations. This suggests that current recommendations are underestimated. Studies in adults have shown that protein recommendation set on the basis of nitrogen balance data, while sufficient to maintain nitrogen balance, does not maintain GSH status.

Glutathione (GSH) is most important intracellular antioxidant and scavenger and its deficiency has been shown to compromise recovery in acute as well as chronic stressors. Deficiency of GSH results when protein and/or cysteine intake is inadequate. Inadequate protein intake in children not only compromises growth, but could increase susceptibility to, and compromise recovery from regular childhood illness. Similarly, in young and older adults' inadequate intakes may result in increased oxidative stress and compromised immune function. Measurement of GSH synthesis provides a functional method whereby the current protein recommendation can be tested against higher estimates derived using the IAAO method. The purpose of this study therefore is to measure GSH synthesis in healthy school aged children (6-11 years), and healthy young (19 - 40 years) and old (60 - 90 years) adults in response to current recommended protein intakes and in response to protein requirement estimates derived using the IAAO method.

In healthy school-aged children, each level of protein will be studied over three days. For two days (adaptation days), participants will eat some low protein foods plus a milkshake drink. On the study day, participants will consume 8 hourly protein drinks and special cookies at SickKids. In healthy young and old adults, each level of protein will be studied over three days. For two days (adaptation days), young adults will eat some low protein foods plus a milkshake drink. On the one study day, young adults will consume 10 hourly milkshake diets at SickKids. In old adults, each level of protein will be studied over four days. For three days (adaptation days), old adults will eat some low protein foods plus a milkshake drink. On the one study day, old adults will consume 10 hourly milkshake diets at SickKids.
This cohort will consist of patients undergoing bariatric surgery who are currently receiving a GLP-1 Agonists for weight loss and/or diabetes management, that will be maintained on their preoperative dose of GLP-1 agonist following their bariatric surgery. This includes semaglutide, tirzepitide, among others. The dosage will be variable, but will be the same dose the patient is on prior to the bariatric surgery. Duration will be one of the aims of the study.
PURPOSE:To conveniently obtain a substance soluble in an org. solvent in high yield by dipping a sample body contg. a substance to be extracted soluble in the org. solvent through a porous membrane. CONSTITUTION:The sample body 1 contained in a porous membrane 3 consisting of a polyimide film, etc., and an org. solvent 2 are supplied into an extraction vessel 4. The amt. of the org. solvent is so regulated that the sample body 1 is sufficiently immersed. The extraction vessel 4 is heated by using a heater 5, cooling water is passed through a Dimroth condenser 6, the org. solvent in the extraction vessel 4 is refluxed and the substance to be extracted in the sample body 1 is extracted into the org. solvent. The substance dissolved in the org. solvent is permeated through the porous membrane 3. The substance insoluble in the org. solvent is incapable of being permeated through the porous membrane 3. Consequently, the substance in the sample body 1 soluble in the org. solvent and the substance insoluble in the org. solvent are separated by the porous membrane 3.
PURPOSE: To obtain a stabilized sustained release emulsion, comprising a lipophilic external phase and a hydrophilic internal phase containing a pharmaceutically active ingredient and a gelling agent, substantially insoluble in the lipophilic external phase and incorporated thereinto and suitable for oral administration. CONSTITUTION: This stabilized sustained release emulsion comprises a lipophilic external phase and a hydrophilic internal phase, containing a pharmaceutically active ingredient substantially insoluble in the lipophilic external phase and a gelling agent (e.g. carboxymethyl cellulose) and incorporated thereinto. The external phase of the emulsion is composed of a nontoxic lipophilic medium, e.g. lard, peanut oil or sesame oil and the internal phase thereof is composed of a nontoxic hydrophilic medium, e.g. water, glycerol or propylene glycol. The emulsion contains the hydrophilic phase in an amount of about 20 to about 60wt.%, preferably about 25 to about 35wt.% based on the total weight of the emulsion and the lipophilic phase in an amount of about 40 to about 80wt.%, preferably about 65 to 75wt.% based on the total weight of the emulsion.
Patients with NTRK1, NTRK2, NTRK3, OR ROS1 fusion receive entrectinib PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unaccepted toxicity.
The design will be a 2 (player vs. observer) x 3 (nonviolent, violent with sword, violent with gun) between-subjects study. Participants will randomly be assigned to conditions. Participants will be tested in pairs. The participant in the player condition will play a video game while the participant in the watcher condition will watch. The participants will be in the same room, seated next to each other.

Video games will be chosen for the three conditions which have no violent content (nonviolent condition), violent content with a sword as a weapon for the player (violent with sword condition), and violent content with a gun as a weapon (violent with gun condition). All games chosen will be age appropriate (rated E) and have a consistent perspective (i.e., 1st person or 3rd person) between conditions. Participants will be asked how familiar they are with the video game used to control for experience with the stimulus. Gameplay will last for 20 minutes.

The measures for experiment 3 will include the media habits, aggressive behavior, attitude toward guns, and guns in the home measures listed for experiment 1. In addition, parents will be asked if their children have taken a gun safety course and a behavioral measure will be whether or not children handle a real (but non-firing) gun and whether they pull the trigger.

Participants will be tested in pairs, with a sibling or friend. Participants will be placed in a room containing toys, with a camera on the wall. Participants will be told that they can play with any of the toys in the room for the next 20 minutes. The toys will be placed will be placed in drawers inside a cabinet. Inside the room, two brightly colored plastic Nerf dart guns and two handguns will be placed in separate drawers, as in previous research. The handguns will be modified so they cannot fire. Inside the magazine, the handguns contain no bullets. They do, however, contain a sensor that counts the number of times the trigger is depressed with sufficient force to discharge the weapon. This allows us to distinguish reliably the children who pull the trigger from those who only handle the gun. Parents will be asked to predict whether their child will handle the real gun and pull the trigger. The researcher and the parents will be able to watch the session via a monitor in a control room. A thorough debriefing will follow (see attachment). The investigators also have received letters of support from the Director of the School of Communication and from the Chief of Police (see attachments). The investigators predict the highest levels of playing with guns and firing them among participants who see a violent clip containing guns.