anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A preparation method of a skin-care composite facial mask fluid is disclosed. Main raw materials include konjac glucomannan, k-carrageenan, isolated soybean protein, collagen, propolis and vitamin E. The preparation method comprises the preparation of konjac glucomannan sol, the preparation of compound protein solution, the preparation of k-carrageenan solution and the preparation of sucrose fatty acid ester diluent, and compound and blending of all the materials. The konjac glucomannan is a natural biological polymeric membrane material having excellent performance, and has excellent performances such as water sucking property, moisture preservation property, membrane formation property, gelation property, degradability and the like. Through the physical mixing of the konjac glucomannan with the k-carrageenan and the isolated soybean protein, the thermal properties and the mechanical properties of the membrane can be improved; and through formulation, a non-toxic, efficient and good-performance skin-care facial mask fluid is formed. The konjac glucomannan has a unique property of being liquid at a temperature below 10 DEG C and being naturally formed into a membrane at the normal temperature; therefore, the skin-care composite facial mask fluid is applied to face and a membrane can be naturally formed. The skin-care composite facial mask fluid of the invention is colourless and transparent, convenient for use, and non-toxic and safe.
Prior to each subject's radiation treatment (either whole brain radiation therapy or stereotactic radiosurgery), he/she will have fMRI scanning and neuropsychological testing and conduct a quality of life assessment. Each subject will then have standard of care WBRT or SRS treatment. Following WBRT or SRS treatment, subjects will have 4 month follow up fMRI scanning, and have neuropsychological testing and a quality of life assessment 4 months and 12 months post treatment.
Local vibration (LV) mainly stimulates primary afferents (Ia) and can induce a tonic vibration reflex (TVR) and an illusion of movement. This study aimed to evaluate the effect of these two phenomena on maximal voluntary isometric contraction (MVIC) capacity. LV (80 Hz) was applied to the wrist flexor muscles in two randomized experiments for 6 min. LV conditions were adjusted to promote either TVR (visual focus on the vibrated wrist) or ILLUSION [hand hidden, visual focus on electromyographic activity of the flexor carpi radialis muscle (FCR)]. Mechanical and electromyographic (EMG) responses of the FCR and extensor carpi radialis muscles were recorded during MVIC in flexion and extension and during electrically evoked contractions at supramaximal intensity. Measurements were performed before (10 min and just before) and after (0 and 30 min) LV protocol. An increase in FCR EMG was observed during LV in the TVR condition (+340%) compared with the illusion condition (P = 0.003). In contrast, the movement illusion was greater in the ILLUSION condition (assessed through subjective scales) (P = 0.004). MVIC was reduced in flexion only after the TVR condition ([Formula: see text], all P < 0.034). Moreover, the decrease in force was correlated with the amount of TVR recorded on the FCR muscle (r = -0.64, P = 0.005). Although potentiated doublets of each muscle did not evolve differently between conditions, a decrease was observed between the first and the last measure. In conclusion, when conducting research to assess maximal strength, it is necessary to have better control and reporting of the phenomena induced during LV.NEW & NOTEWORTHY The maximal force production of the vibrated muscle is reduced after 6 min of LV only in TVR condition. Furthermore, the amount of TVR is negatively correlated with this force decrease. When measuring the effects of LV on maximal force production, it is important to control and report any phenomena induced during vibration, such as TVR or movement illusion, which can be achieved by recording EMG activity of vibrated muscle and quantifying illusion.
FIELD: medicine; nephrology. SUBSTANCE: method includes ultrasonic examination of kidneys. Vascular blood flow in capillaries is estimated on level of glumerules by indices of vascular resistance in arcuate artery. If these indices are below normal ones capillary blood flow in kidney glumerules is affected. In this case, disturbance of microcirculation is diagnosed. Efficiency of medicinal therapy performed is judged by values of the indices. Course of treatment is continued till indices are normalized. Quick and objective estimation of treatment efficiency provides for performance of adequate correction of therapy with due regard for individual features of every patient. EFFECT: quick and stable therapeutic effect, reduced terms of treatment.
Interested participants will be invited to an orientation where study procedures will be explained in detail. Once the consent form is signed participants will schedule a visit to provide blood, urine and stool samples at the beginning of the intervention at which point they will be randomized into one of three groups: a fermented vegetable group (1/2 cup per day for 6 weeks), a non-fermented vegetable group (1/2 cup per day for 6 weeks) and a control group (usual diet). Both vegetable groups will receive weekly deliveries of the vegetables to be consumed. Following 6 weeks, participants will provide blood, urine and stool samples one more time. Participants will also fill out questionnaires related to dietary intake, demographics, physical activity, prescription medication use and gastrointestinal function. Compliance will be monitored weekly via a gastrointestinal function log where participants will be asked to enter whether they consumed or not the vegetable provided each day, as well as any side effects of consumption.
Previous studies have shown that propofol is superior to traditional sedation regimens with benzodiazepines plus opioids in ERCP procedures. Propofol is a potent hypnotic drug with a short duration of action and consequently a more rapid recovery time for the patients compared with the available Benzodiazepines. Several prospective studies have shown that balanced propofol sedation (BPS) can be used safely and effectively for diagnostic endoscopy under the direction of a gastroenterologist. BPS which was originally described by Cohen et al, combines small incremental doses of propofol with single induction doses of benzodiazepines and opioids under the direction of a physician that is not an anesthesiologist. Because BPS usually targets moderate sedation, adequate amnesia and analgesia can be achieved with concomitant administration of benzodiazepines and opioids. It may cause synergism between propofol and midazolam and reduce dose of propofol. However, there was no proven benefit between propofol alone titrated to moderate level of sedation and BPS; propofol titration combination with benzodiazepines and fentanyl.
It is found out that m-calpain or .mu.-calpain degrades hepatocyte nuclear factor 4.alpha. (HNF-4.alpha.), hepatocyte nuclear factor 1.alpha. (HNF- 1.alpha.) and insulin promoter facotr 1 (IPF-1) which form a transcriptional factor network participating in the expression of a saccharomyces-associated gene in pancreatic .beta.-cells. Thus, a method of degrading these transcriptional factors; a method of inhibiting the degradation; a degradati on inhibitor; a promoter for the production of a gene product of a gene on whic h these factors serve as transcriptional factors and a method of promoting the production; a preventive and/or a remedy for a disease caused by the degradation of these transcriptional factors and a method of preventing and/ or treating the same; a method of identifying a compound inhibiting the degradation of these transcriptional factors by calpain; a compound obtained by the identification method; and a reagent kit containing calpain, these transcriptional factors, polynucleotides encoding these transcriptional factors, and a vector containing these polynucleotides; are provided.</SDOAB >
Methods for preparing a dried cold-soluble milk protein concentrate (MPC) or milk protein isolate (MPI). The methods generally involve: a) Providing an MPI or MPC having at least 70% dry matter as milk protein in aqueous solution/suspension. b) Adding at least one monovalent salt in an amount that confers enhanced solubility on the product when dried; and c) Drying the product Wherein the amount of cation added is 0.013-0.30 moles of cation per 100g protein. An additional step may be added after step a) that involves removing part of the water from the MPC or MPI. Variations on the method are also disclosed, these include beginning with a skim milk solution, adding at least one monvalent salt to this and then concentrating the solution by ultrafiltration, optionally with diafiltration to form an MPI or MPC having at least 70% dry weight as protein and drying to prepare a dried product with enhanced solubility. The MPC and MPI is useful in chesse manufacture.
PURPOSE: An aerosol type spray is provided to have excellent hair setting property. CONSTITUTION: An aerosol type spray contains a hair styling crude liquid and a spray agent. The hair styling crude liquid contains 0.5-10 mass% of acrylic acid hydroxyethyl/acrylic acid methoxyethyl copolymers. The spray agent contains dimethyl ether and liquefied petroleum gas. The ratio of dimethyl ether is 45-80 mass%. The ratio of the hair styling crude liquid is 45-55 mass%.
Chimeric antigen receptor (CAR) T cell therapy has proven effective in treating B cell malignancies. However, the application itself is still limited by the high cost and long preparation time which often do not meet the urgent need of patients. In addition, some patients may suffer from long-term immunosuppression caused by tumor microenvironment or after radiotherapy and chemotherapy, resulting in exhaustion, aging and functional defects of the autologous T cells, which will eventually affect the quality of the CAR-T cells and affect the clinical efficacy.

The 4SCAR19U T cells are genetically engineered and manufactured in bulk amount that can be supplied off-the-shelf without being custom made from individual patients. The immediate availability of the CAR-T cells makes clinical treatment convenient and timely for rapid progressing disease or for the highly immune suppressed patients. This application can be time- and cost-effective. This novel approach may also overcome problems of functionally defective autologous T cells. The purpose of this clinical trial is to assess the feasibility, safety and efficacy of the 4SCAR19U T cell product in hematological malignancies. Another goal of the study is to learn more about the function of this novel product and its persistence in the patients
This is a single-arm intervention where patients will receive concurrent therapy with BV+CHEP \[(brentuximab vedotin; 1.8 mg/kg IV, on D1 every 21 days) (cyclophosphamide 750 mg/m\^2 on D1; doxorubicin 50 mg/m\^2 on D1, etoposide 100 mg/m\^2 IV infusion on D1-3; prednisone 100 mg orally once daily on D1-5; cycle length every 21 days)\] for 2 to 6 cycles of induction therapy. After 6 cycles of BV + CHEP, responders (CR, PR or SD) who are not eligible for BMT and have CD30-positive ATLL will continue maintenance therapy with BV alone (1.8 mg/kg IV, every 21 days) until disease progression, withdrawal due to toxicity or death.
Participants will receive inavolisib in escalating dose levels along with letrozole on Days 1-28 of each 28-day cycle. The starting dose of inavolisib will not exceed the starting dose in Stage I Arm A. Participants will continue treatment until the end of the study in the absence of unacceptable toxicities and unequivocal disease progression.
BACKGROUND: Unstable femoral trochanteric fractures (FTFs), especially Arbeitsgemeinschaft für Osteosynthesefragen/ the Orthopedic Trauma Association (AO/OTA) 31-A2 fractures, which are multifragment fractures, occur in elderly individuals with osteoporosis and are associated with high mortality and complication rates due to prolonged immobilization. Longer nails (LNs) were developed to obtain superior fracture site stabilization in unstable FTFs. We hypothesized that the postoperative outcomes of elderly patients with unstable FTFs treated with LNs would be superior to those of patients treated with short nails (SNs), with fewer complications.
METHODS: This multicenter retrospective study aimed to compare the outcomes of SNs versus LNs in elderly patients with unstable FTFs. From the Trauma Research Group of our university (TRON) database, 1854 trochanteric fractures treated between January 2016 and December 2020 were extracted. A total of 174 patients>65 years of age with AO/OTA 31-A2 fractures were included in the present study. They were divided into the SN group and the LN group and matched for age and sex. Parameters such as operative time, blood loss, survival rate, Parker Mobility Score (PMS), and numerical rating scale (NRS) for pain, complications, and radiographic findings were analyzed.
RESULTS: Both groups included 67 patients with an average age of 87.32 years. The LN group had a longer operative time (76.52 min vs. 51.61 min, P < 0.001) and more blood loss (106.79 mL vs. 49.98 mL, P = 0.014) in comparison to the SN group. However, the 1-year survival rate, PMS, and NRS for pain did not differ to a statistically significant extent between the groups. The rates of complications, including screw cutout, nonunion, implant breakage, osteonecrosis of the femoral head, and surgical site infections, were comparable. The radiographic findings, including the nail/canal ratio, progression of varus, and sliding distance, were also similar.
CONCLUSION: Although LNs are associated with longer operative times and increased blood loss, the overall outcomes and complication rates are comparable to those of SNs in elderly patients with AO/OTA 31-A2 type unstable FTFs. The use of LNs did not confer any distinct advantages for this specific type of fracture.
The brown planthopper (BPH) is one of the most problematic pests affecting rice (Oryza sativa L.) yields in Asia. Breeding rice varieties containing resistance genes is the most economical and effective means of controlling BPH. In this study, the key factors in resistance to BPH were investigated between the high-resistance rice variety "R26" and the susceptible variety "TN1" using RNA-sequencing. We identified 9527 differentially expressed genes (DEGs) between the rice varieties under BPH-induced stress. Weighted time-course gene co-expression network analysis (WGCNA) indicated that the increased expression of genes is associated with plant hormones, MAPK signaling pathway and biosynthesis of other secondary metabolites, which were involved in disease resistance. A connection network identified a hub gene, OsREM4.1 (BGIOSGA024059), that may affect rice resistance to the BPH. Knocking out OsREM4.1 in rice can lead to a decrease in callose, making it less resistant to BPH. Overall, the expression of differentially expressed genes varies among rice varieties with different resistance in BPH invasion. Inaddition, R26 enhances resistance to BPH by upregulating genes and secondary metabolites related to stress resistance and plant immunity. In summary, our study provides valuable insights into the genome-wide expression profile of DEGs in rice under BPH invasion through high-throughput sequencing, and further suggests that R26 can be used to develop high resistance rice lines in BPH resistant breeding programs.
BACKGROUND: Spontaneous non-traumatic subarachnoid hemorrhage (sSAH) is a severe brain vascular accident. Glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) can be theoretically assayed to predict a patient's progression, picturing different aspects of clinical failure after sSAH. The study aims to: a) explore the correlation between sSAH blood volume and biomarkers variation; b) evaluate if these can be predictive of the neurogenic response after sSAH and be prognostic of patient outcome; c) establish eventual threshold levels of biomarkers to define patients' clinical outcome.
METHODS: Blood volumetry at CT scan upon admission, GFAP and UCH-L1 were collected at 24 h, at 72 h, and after 7 days from hemorrhage. Trends and cut-off serum sampling were determined. Clinical outcome was assessed with mRS scale at 14 days.
RESULTS: A strong correlation between GFAP and UCH-L1 and blood diffusion volume in all explored serum intervals related to unfavorable outcome. GFAP and UCH-L1 were very early predictors of unfavorable outcomes at 24 h from sSAH (p = 0.002 and 0.011 respectively). Threshold levels of UCH-L1 apparently revealed a very early, early and late predictor of unfavorable outcomes.
CONCLUSION: GFAP and UCH-L1 represent a potential tool for prompt monitoring and customization of therapies in neurosurgical patients.
Chronic pain is associated with psychological and mental health disorders. Many patients have personality and behavioral disorders. Some patients harass their pain care providers. Most healthcare staff do not report harassment by patients.

This is a quantitative and qualitative analysis of prospective electronic and clinic diary data. It is an evaluation of incidents of pain clinic staff harassment; caused by patients and patients' family. This is an analysis of incident causative factors, incident outcome and lessons learned. The qualitative information of each incident is presented in a sensitive and careful format.
A hair lacquer for use in a pressurised container and sprayable with a propellant gas, consists of at least one hair- setting agent (I) and also propolis (II; a natural resinous or gummy material obtd. from the bud-scales of alder trees, etc.). Pref. (I) is a natural gum or resin, esp. gum arabic and the propellant is esp. nitrous oxide at a pressure of about 8 bars. The compsn. is made of natural materials and does not require a polluting propellant. (II) has good affinity for keratin and acts as a bactericide with good resistance to moisture in the air. Although (I) is not itself a satisfactory setting agent it improves the properties of compsns. contg. (I), particularly as regards the suppleness of the hair and allows the amt. of (I) to be reduced.
This is an open label, single-arm, single-institution, Phase I study designed to investigate the safety and efficacy of personalized cellular tumor vaccine for patients with newly diagnosed glioblastoma (GBM). Newly diagnosed GBM patients will undergo tumor resection. The tumors will be analyzed for the expression of a panel of glioma-associated antigens and immune-related genes. Post surgical treatment will be 6 weeks standard chemotherapy with temozolomide and concurrent radiotherapy and continue cycles of temozolomide within a 28-day window. Patients will undergo leukapheresis either after surgery or after concurrent radio/chemotherapy. Based on individual tumor antigen expression, in vitro transcribed mRNA will be generated and used to pulse in vitro generated DCs. The patients will be immunized i.d. and i.v. biweekly with DC cellular vaccines. Safety and efficacy will be monitored. The primary objective is to assess the safety of the personalized cellular vaccines. The secondary objective is to assess the specific T cell response to immunized vaccines. In addition, the antitumor efficacy of the vaccines will be measured using iRANO criteria, progression-free survival and overall survival.
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Avoid temperatures over 40°C (104°F).

Gleostine is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1

To minimize the risk of dermal exposure, always wear impervious gloves when handling bottles containing Gleostine capsules. Do not break Gleostine capsules; avoid exposure to broken capsules. If dermal contact occurs, wash areas of skin contact immediately and thoroughly.
PURPOSE:To make it possible to fix a homogeneous physiological active material surely by dispersing magnetic ultraminute corpuscles in a solvent, and sequentially adding fatty acid and phospholipid into the solvent. CONSTITUTION:Magnetic ultraminute corpuscles are dispersed into a solvent. Fatty acid and phospholipid are added into the solvent. A fatty acid film is formed on the surface of the magnetic ultraminute corpuscles. Phospholipid is further added into the solvent. A phospholipid film is formed on the fatty acid film. As the solvent for dispersing the magnetic ultraminute corpuscles, alkaline aqueous solution such as aqueous ammonia is available. In order to disperse the magnetic ultraminute corpuscles into the solvent, e.g. ultrasonic wave are projected into the solvent, and the magnetic ultraminute corpuscles are added and dispersed under this state. As the fatty acid, there is saturated fatty acid such as oleic acid. It is desirable that the concentration of the solution wherein the fatty acid is added is made to be critical micelle concentration. As the phospholipid, natural phosphatidylcholine and the like are available.
Single blind, Placebo arm study drug will contain 994.0 mg of corn oil and 6mg of alpha tocopherol as an excipient in a soft gelatin capsule shell. Subjects will take 4g daily for a minimum of 48 weeks.
Disclosed are various systems and techniques for performing video-based surgeon technical-skill assessments and classifications. In one aspect, a process for classifying a surgeon's technical skill in performing a surgery is disclosed. During operation, the process receives a tool-motion track comprising a sequence of detected tool motions of a surgeon performing a surgery with a surgical tool. The process then generates a sequence of multi-channel feature matrices to mathematically represent the tool-motion track. Next, the process performs a one-dimensional (1D) convolution operation on the sequence of multi-channel feature matrices to generate a sequence of context-aware multi-channel feature representations of the tool-motion track. The sequence of context-aware multi-channel feature representations is subsequently processed by a transformer model to generate the skill classification, wherein the transformer model is trained to identify and focus on a subset of tool motions in the sequence of detected tool motions that are most relevant to the skill classification.
Medicaments protected by an enteric material by a process comprising coating with a thin film comprising calcite, a basic silicate, fuller's earth, diatomaceous earth, bentonite, kaolin, calamine or zinc oxide or mixtures thereof, the particle size of said materials being less than fifty microns, dispersed in a hydrolysed styrene maleic anhydride copolymer which is more than 50% hydrolysed.  It is preferred that the copolymer should have a molar ratio of about 1 maleic acid residue to from one to about four styrene residues.  The copolymer may be plasticized by compounds such as dibutyl phthalate, diethyl phthalate, dioctyl phthalate, polyethylene glycols and glyceryl mono-oleate, and it may be used as a non-toxic water-soluble salt e.g. the ammonium or alkali metal salt.  Other ethylenic units which may be present include acrylonitrile, acrylic acid, methacrylic acid, itaconic acid, vinyl chloride or vinylidene chloride.  The enteric material may be applied as a coating or formed as a capsule shell. Medicaments which may be coated include those specified in the parent Specification and also the adrenocortical steroids.
The child health education condition will participate in a family-based obesity treatment program for the first 40 minutes of each session, followed by 20 minutes designated to education about a child health topic. Parents and children will be asked to self-monitor sugar-sweetened beverages, fruits, vegetables, and minutes of physical activity and screen time.