anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cpds. (II) for radiation therapy or diagnostics contg. Mossbauer absorbing nuclides (I), either in natural isotopic ratios or in enriched form, are new. (I) is an element from transition gps. VII or VIII, esp. Ru or Fe. (II) are esp. metallocene or half-sandwich-carbonyl complexes, which may be bound e.g. to mono- or polyclonal antibodies, esp. those against tumour antigens. USE/ADVANTAGE - (II) contain Fe enriched with 57Fe (most suitable for therapy) or contain Ru enriched with 99Ru (most suitable for diagnostics). The cpds. are stable so metal ion exchange does not take place and they are usually hydrophobic, so they are not readily removed from the body. Some (II) have high affinity for certain organs. Thus ferrocenyl-glycine has affinity for the kidney and 1-ferrocenyl-2-amino-propane and its N-alkyl derivs. have high affinity for the brain.  Excitement of e.g. a 57Fe atom in an organ with gamma-rays causes a localised Auger cascade and a very high localised radiation effect.
Postoperative abdominal adhesion is one of the most common complications after abdominal surgery. The Toll-like receptor 4 (TLR4) signaling pathway is one of the most common inflammation-related pathways, and it has been demonstrated that TLR4 is highly expressed in adhesive tissues; however, the function of TLR4 in adhesion formation has not yet been studied. In the present study, the expression of TLR4 was first detected by immunohistochemical (IHC) and double-immunofluorescence staining in 40 mice, which were randomly divided into four groups, and sacrificed at 1, 3, 5 and 7 days after surgery. Subsequently, another 40 mice were randomly divided into five groups; with the exception of the sham group, the other groups were modeled and treated with saline that contained DMSO, sodium hyaluronate (HA), TAK-242 or TAK-242 + HA (applied to damaged peritoneal wounds). A total of 7 days after surgery, the mice were sacrificed and specimens were collected. Inflammation was detected by hematoxylin and eosin staining, and ELISA of transforming growth factor- β1 (TGF-β1) and interleukin-6 (IL-6); collagen deposition was examined by Masson staining and IHC staining of α-SMA; and reactive oxygen species (ROS) were detected by ROS staining and malondialdehyde (MDA) assay. The results revealed that TLR4 was highly expressed in the adhesive tissues at 3, 5 and 7 days after surgery. In addition, TAK-242 + HA treatment could reduce abdominal adhesion formation, exhibiting lower Nair's score and inflammation scores, lower TGF-β1 and IL-6 levels, and lower collagen thickness and α-SMA levels compared with those in the control group. In addition, the TAK-242 + HA group had lower levels of ROS and MDA compared with those in the control group. The present study revealed that TLR4 was highly expressed in the process of adhesion formation and its inhibitor, TAK-242, combined with HA, could reduce adhesion formation by reducing inflammation and ROS, and alleviating collagen deposition.
Cocaine use in the general population is a significant and costly problem. Novel and innovative interventions targeting cocaine abuse are needed. The Transtheoretical Model of behavior change (TTM) offers a comprehensive framework for understanding, measuring, and intervening in behavior change and provides a strong theoretical foundation upon which effective treatments for substance abuse can be developed. The proposed Stage 1 research will pilot test a novel and innovative behavioral group therapy for cocaine users based on the TTM. In Phase 1, investigators will modify the newly developed Group Treatment for Substance Abuse: A Stages-of-Change Therapy Manual (Velasquez, Maurer, Crouch \& DiClemente, 2001) to specifically target cocaine abuse resulting in a twelve-session, group intervention and accompanying therapy manual based on the TTM stages and processes of change: six "early stage" sessions targeting the experiential processes of change, and six "later stage" sessions targeting the behavioral processes of change. Phase 2 will consist of a pilot trial to evaluate the TTM group therapy with cocaine abusing patients. A randomized, controlled, between groups design will be used in which cocaine abusers (N=80) are assigned to one of two group treatment conditions: TTM therapy or Education/Advice. Participants will be recruited from Houston and surrounding communities through the Substance Abuse Research Center at the University of Texas Health Science Center Mental Sciences Institute. We expect the delivery of the TTM therapy for cocaine users to be feasible and acceptable, and to produce significant patient improvement. Cocaine outcomes will be assessed via objective (urine and drug analysis) and self-report measures. This Stage I research will contribute important theoretical and empirical information concerning the promise of a new and innovative intervention for cocaine abusers, and will provide the basis for a larger efficacy trial.
Immune-mediated inflammatory diseases (IMIDs) are recognised risk factors for accelerated atherosclerotic cardiovascular disease (CVD), particularly in younger individuals and women who lack traditional CVD risk factors. Reflective of the critical role that inflammation plays in the formation, progression and rupture of atherosclerotic plaques, research into immune mechanisms of CVD has led to the identification of a range of therapeutic targets that are the subject of ongoing clinical trials. Several key inflammatory pathways implicated in the pathogenesis of atherosclerosis are targeted in people with IMIDs. However, cardiovascular risk continues to be systematically underestimated by conventional risk assessment tools in the IMID population, resulting in considerable excess CVD burden and mortality. Hence, there is a pressing need to improve methods for CVD risk-stratification among patients with IMIDs, to better guide the use of statins and other prognostic interventions. CT coronary angiography (CTCA) is the current first-line investigation for diagnosing and assessing the severity of coronary atherosclerosis in many individuals with suspected angina. Whether CTCA is also useful in the general population for reclassifying asymptomatic individuals and improving long-term prognosis remains unknown. However, in the context of IMIDs, it is conceivable that the information provided by CTCA, including state-of-the-art assessments of coronary plaque, could be an important clinical adjunct in this high-risk patient population. This narrative review discusses the current literature about the use of coronary CT for CVD risk-stratification in three of the most common IMIDs including rheumatoid arthritis, psoriasis and systemic lupus erythematosus.
A method is presented for determining onset of hypoxia of an occupant in an aircraft. The method includes measuring a physiological parameter of the occupant and comparing a value based on the physiological parameter with a threshold value. The method also includes measuring a pressure within a cabin of the aircraft and comparing the pressure with a pressure threshold value. The method also includes determining onset of hypoxia of the occupant based on both of the comparing steps. The method also includes communicating an alert to the occupant using a device detectable by one or more senses of the occupant. An apparatus is also provided for determining onset of hypoxia. The apparatus includes a pressure sensor to measure the pressure, a pulse oximeter to measure the physiological parameter, an alert device to communicate the alert to the occupant and a processor to perform one or more steps of the method.
Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.R1058C, and p.R1142X) in 6 children from 3 unrelated families with a similar syndrome of autoinflammation and autoimmunity. We showed that these CTD COPA mutations disrupt the integrity and the function of coat protein complex I (COPI). In COPAR1142X and COPAR1058C fibroblasts, we demonstrated that COPI dysfunction causes both an anterograde ER-to-Golgi and a retrograde Golgi-to-ER trafficking defect. The disturbed intracellular trafficking resulted in a cGAS/STING-dependent upregulation of the type I IFN signaling in patients and patient-derived cell lines, albeit through a distinct molecular mechanism in comparison with mutations in the WD40 domain of COPA. We showed that CTD COPA mutations induce an activation of ER stress and NF-κB signaling in patient-derived primary cell lines. These results demonstrate the importance of the integrity of the CTD of COPA for COPI function and homeostatic intracellular trafficking, essential to ER homeostasis. CTD COPA mutations result in disease by increased ER stress, disturbed intracellular transport, and increased proinflammatory signaling.
<P>PROBLEM TO BE SOLVED: To realize useful data management for assisting analysis and treatment.  <P>SOLUTION: Method and clinical analysis system are provided to realize data management for assisting the analysis and treatment. The clinical analysis system includes a biosensor for receiving and processing a user specimen, and a memory as means for storing two or more patient records including a designated parameter data value. A processor device is connected to the biosensor for receiving and processing two or more patient records and creating a report. A fax drive mechanism connected to the processor device transmits the created report through a telephone network to a designated fax machine in a clinic.  <P>COPYRIGHT: (C)2004,JPO
Minoxidil is at least 90% absorbed from the Gl tract in experimental animals and man. Plasma levels of the parent drug reach maximum within the first hour and decline rapidly thereafter. The average plasma half-life in man is 4.2 hours. Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself; all are excreted principally in the urine. Minoxidil does not bind to plasma proteins and does not cross the blood brain barrier. Its renal clearance corresponds to the glomerular filtration rate. In the absence of functional renal tissue, minoxidil and its metabolites can be removed by hemodialysis.
A method for producing amidated cosmetic pectine involves hydrolysis-extraction, separation of solid and liquid phases, cooling, treatment of pectine extract with trilon B, mixing and settling, saponification with solution of alkali, neutralization , deposition of pectine with dimethyl formamide, treatment of coagulant with aqueous-acetone solution. Hydrolysis-extraction are performed at the temperature of 85-90 DEGREE C during 80-100 min. After settling pectine extract saponification-amidation is performed with ammonium solution at pH of 8.5-8.8. Following neutralization non-ionic surface-active substances are added at an amount of 1 %. The pectine extract is sprayed above the solution of calcium salt. Pectine coagulant is separated by centrifugation. The obtained coagulant is filled up with acid solution having pH of 3.4-4.0.
The second level prophylactic use of PEG-rhG-CSF. The Prophylactic use of PEG-rhG-CSF in the next cycle until FN or 4 grade neutropenia happened.
The invention discloses tooth brushing medicinal liquid for preventing and treating odontopathy. The tooth brushing medicinal liquid is prepared from the following raw materials in parts by weight: 50-100 g of a dry mock-strawberry herb and 10-30 g of dry eulaliopsis binata and is formed by soaking the two traditional Chinese medicines in 1,200-2,600 g of white wine with the alcohol degree of 52 DEG for one month and filtering the medicines. Preferably, the tooth brushing medicinal liquid is prepared from 80g of a dry mock-strawberry herb and 20g of underground dry eulaliopsis binata. The tooth brushing medicinal liquid is applied for many years, and the total efficiency of preventing and treating periodontitis, saprodontia and hypersensitive dentin and eliminating dental plaque is over 95 percent. A using method of the tooth brushing medicinal liquid is that before going to bed, a user continuously brushes teeth by extruding toothpaste on a health care toothbrush and dropping 7-8 drops of the tooth brushing medicinal liquid for more than 100 days; and kids incapable of brushing teeth and suffering from the saprodontia can continuously eat an egg boiled in 40ml of the medicinal liquid every day for more than 5 days. The tooth brushing medicinal liquid has the characteristics of low cost, simplicity in preparation, extremely poor toxic and side effect and remarkable treating effect.
AIMS: Postoperative cognitive dysfunction (POCD) is a common complication associated with poor outcome. Our previous study has shown that living with familiar observers in the same cage reduces anxiety of mice with surgery. Anxiety can impair learning and memory. Thus, this study was designed to determine whether living with familiar observers attenuated the dysfunction of learning and memory of mice with surgery.
METHODS: Six- to eight-week-old CD-1 male mice or 18-month-old C57BL/6 male mice had left carotid artery exposure under isoflurane anesthesia. They lived with non-surgery male mice at 2 (number of surgery mice) to 3 (number of non-surgery mice) ratio or with other surgery mice. Mice were subjected to light and dark box test 3 days after surgery to measure their anxiety levels and novel object recognition and fear conditioning tests from 5 days after surgery to measure their learning and memory. Blood and brain were harvested for biochemical analysis.
RESULTS: Living with familiar observers that lived with surgery mice for at least 2 weeks before the surgery and then after surgery reduced the anxiety and dysfunction of learning and memory in young adult male mice. Living with unfamiliar observers that lived with surgery mice after the surgery but not before the surgery did not have those effects on the mice with surgery. Living with familiar observers attenuated learning and memory dysfunction after surgery also in old male mice. Living with familiar observers attenuated inflammatory response in the blood and brain and the activation of the lateral habenula (LHb)-ventral tegmental area (VTA) neural circuitry, which has been shown to be important for POCD. Wound infiltration with bupivacaine attenuated the activation of LHb-VTA.
CONCLUSION: These results suggest that living with familiar observers attenuates POCD and neuroinflammation, possibly via inhibiting the activation of the LHb-VTA neural circuitry.
Eligible patients with written informed consent, scheduled for laparoscopic bariatric surgery. As for standard of care no premedication will be given for bariatric patients. Patients will be monitored according the local standard.

Thoracic electrical impedance tomography measurements (each measurement will last 1 min) will be performed at the following time points: before induction of the anaesthesia; before the surgical procedure when the induction is terminated and recruitment manoeuvers have been performed; after the termination of the surgical procedure; before transport to the Post anaesthesia Care Unit (PACU); before the discharge from the PACU after 2 hours of monitoring. An additional thoracic electrical impedance tomography measurement (duration 1 min) will be performed before discharge at home. For this, resulting potential differences are measured, and impedance distribution sampled at 30 Hz will be calculated by an automated linearized Newton-Raphson reconstruction algorithm. Relative change in poorly ventilated lung regions (silent spaces) and end-expiratory lung impedance (EELI) and measures of ventilation inhomogeneity such as the global inhomogeneity index will be calculated.
The invention belongs to the field of pharmaceutical preparations, and particularly relates to a prescription of a glipizide oral instant film and a preparation method thereof. The oral instant film comprises medical active ingredients and pharmaceutically adaptable auxiliary materials. The film comprises the following components in percentage by weight: 1-30% of glipizide, 40-80% of a macromolecular film-forming material, 0-30% of a plasticizer, 0-20% of a corrigent and 0-20% of other auxiliary materials. The film prepared by the glipizide film can be taken without water. The film placed in the oval cavity can be quickly dispersed and dissolved (equivalent to an oral solution) and is swallowed into stomach with saliva. After the film is orally taken, no disintegration process is available, so that the film has the advantages of being quick to absorb, quick to response and high in bioavailability. The product is accurate in dosage, and dust explosion in the production process is nearly avoided, so that the problem on labor protection and environmental pollution can be solved.
The invention comprises sulphonyl ureas of the formula <FORM:0922037/IV(a)/1> wherein X and Y are hydrogen, C1-4 alkyl or alkoxy, e.g. methyl, ethyl, propyl, butyl, isopropyl, isobutyl, methoxy, ethoxy, propoxy, butoxy and sec-butoxy, a C2-4 alkanoyl group, e.g. acetyl, propionyl, butyryl and isobutyryl, halogen, e.g. Cl, Br and F, or a primary amino group.  The compounds are prepared by reacting a benzenesulphonyl urethane which may bear one or two alkyl, alkoxy, alkanoyl, halogen or nitrogen substituents on the benzene ring with 2,5-endomethylene-1,2,5,6-tetrahydrobenzylamine and, if the benzene ring contains a nitro group as a substituent, catalytically hydrogenating the product to give a sulphonyl urea of the above general formula wherein X and/or Y is an amino group. 2,5-Endomethylene -1,2,5,6- tetrahydrobenzylamine used as a starting material is made by treating cyclopentadiene with allylamine or by reacting 2,5-endomethylene-1,2,5,6-tetrahydrobenzaldehyde with hydroxylamine to give 2,5-endomethylene-1,2,5,6-tetrahydrobenzaldehyde oxime which is then reduced with lithium aluminium hydride.  Pharmaceutical preparations having antidiabetic activity and suitable for oral administration comprise the above compounds of the invention in association with a pharmaceutically acceptable carrier.  The preparations suitably take the form of capsules, tablets, powders, pills, granules, suspensions and solutions including suspensions and solutions in oils such as corn, cottonseed, coconut, peanut and sesame oils.  Examples describe preparations containing the compounds of the invention encapsulated in gelatin capsules either in dispersion in corn oil or admixed with corn starch, mineral oil, magnesium stearate and talc; as a suspension in aluminium stearate-corn oil gel; as tablets containing calcium phosphate, methyl cellulose, talc and calcium stearate and as a syrup in aqueous glycerine containing sweetening, flavouring and preserving agents.  Specifications 808,071 and 808,073 are referred to.
Neuroinflammation is a key component underlying multiple neurological disorders, yet non-invasive and cost-effective assessment of in vivo neuroinflammatory processes in the central nervous system remains challenging. Diffusion weighted magnetic resonance spectroscopy (dMRS) has shown promise in addressing these challenges by measuring diffusivity properties of different neurometabolites, which can reflect cell-specific morphologies. Prior work has demonstrated dMRS utility in capturing microglial reactivity in the context of lipopolysaccharide (LPS) challenges and serious neurological disorders, detected as changes of microglial metabolite diffusivity properties. However, the extent to which such dMRS metrics are capable of detecting subtler and more nuanced levels of neuroinflammation in populations without overt neuropathology is unknown. Here we examined the relationship between intrinsic, gut-derived levels of systemic LPS and dMRS-based apparent diffusion coefficients (ADC) of choline, creatine, and N-acetylaspartate (NAA) in two brain regions: the thalamus and the corona radiata. Higher plasma LPS concentrations were significantly associated with increased ADC of choline and NAA in the thalamic region, with no such relationships observed in the corona radiata for any of the metabolites examined. As such, dMRS may have the sensitivity to measure microglial reactivity across populations with highly variable levels of neuroinflammation, and holds promising potential for widespread applications in both research and clinical settings.
PROBLEM TO BE SOLVED: To obtain an antiperspirant composition excellent in antiperspiring effect and its persistency and capable of using by dissolving shower water or by applying to skin moistened after showering or after bathing by combinedly using a perspiration suppressing agent and specific two kinds of compounds. SOLUTION: This antiperspirant composition is obtained by combining (A) perspiration suppressing agent with (B) a polymer absorbable to skin and (C) alcohols. The perspiration suppressing agent includes an aluminum salt, an aluminum zirconium complex or salicylic acid. The polymer absorbable to skin includes a cationic polymer or a carboxybetaine type polymer. The alcohols includes a 1-6C monovalent or polyhydric alcohol. These components A, B and C are each blended in amounts of 0. 01-15wt.%, 0.02-5wt.% and 5-30wt.% based on the composition. The weight ratio of components A/B is preferably (90/10) to (40/60). Furthermore, the composition has good touch feeling to skin.
The use of multiple anticonvulsants may result in an increase of CNS depressant adverse effects. This should be considered before adding clonazepam to an existing anticonvulsant regimen.

Adults

The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg.