anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The patient will be placed in the lateral decubitus position with the area to be treated on the upper side. The high-frequency linear ultrasound probe and the region to be treated will be sterilized. The ultrasound probe will be placed on the anterior line at the level of fourth and fifth ribs. Images of the muscle's latissimus dorsi and serratus anterior, the ribs, and the pleura will be obtained. Subsequently, with the in-plane technique, an 80-mm block needle will be advanced between the latissimus dorsi and the serratus muscles planes in a caudal to the cranial direction. There is no blood or air in aspiration. After confirming the location of the needle with 2 mL of saline solution, (20 mL of bupivacaine 0.25%) will be administered between the two muscles.
Inflammation is involved in the pathomechanism of vascular diseases. Pro-inflammatory cytokines are important in perioperative monitoring. The aim of the study was the perioperative assessment of biochemical tests and inflammatory markers in patients with vasculopathy, focusing on the identification of subjects prone to complications. The study was performed between 2020 and 2023 at the Clinical County Hospital in Târgu Mureș on enrolled diabetic and non-diabetic patients with vasculopathy and lower limb surgery (amputation or necrectomy). Pre- and postoperative inflammatory markers, biochemical, and hematological tests (n = 62) were performed. Positive correlation was found between preoperative C-reactive protein (CRP) and interleukin-6 (IL-6) levels, and between preoperative triglyceridemia and glycemia/cholesterolemia. Positive correlation was present between pre- and postoperative values of IL-6, tumor necrosis factor-alfa (TNF-α), CRP, and fibrinogen. Preoperative TNF-α values positively correlated with malondialdehyde (MDA) levels, postoperative TNF-α values with transaminase enzymes. Diabetic patients presented higher IL-6 results compared to non-diabetic subjects. We can conclude that dynamic assessment of inflammatory markers is appropriate for monitoring perioperative course. Half of the subjects presented moderately increased preoperative IL-6 levels, and one quarter had critically high values, which might predict prolonged hospitalization. The assessment of oxidative stress, inflammatory markers and biochemical parameters enables the identification of patients prone to complications, so they can benefit from more complex management.
The specific aim of this study is to evaluate the clinical effectiveness of inhaled nitric oxide (INO) for the treatment of acute vaso-occlusive pain crisis in pediatric patients with sickle cell disease. Nitric oxide (NO) deficiency is known to be central to the pathophysiology of vaso-occlusion. The aim is unchanged from the original application. The study is a randomized, double blind, placebo controlled, clinical trial with eligible patients randomized to receive either NO (with 21% O2 final concentration) for 16 hrs with 8 hr wean (80 ppm 0-8 hrs, 40 ppm 9-16 hrs, 20 ppm 17-20 hrs, 10 ppm 21-24 hrs) or placebo (21% O2 alone) for 24 hrs. The null hypothesis is that there is no difference in change in mean pain score after 16 hours between patients treated with NO and placebo. The primary outcome measure of the study remains the difference in mean change in pain scores between groups as assessed using a 10 cm visual analogue pain scale (VAS). Secondary outcome measures also remain the same. The study is a next step to our completed FDA Orphan Product Development Grant funded study (FD-R-001686) that evaluated safety and efficacy of NO used for 4 hrs for treatment of vaso-occlusive crisis in pediatric patients with sickle cell disease.
FIELD: veterinary science. SUBSTANCE: preparation abactan - a composition for prophylaxis and treatment of infectious sicknesses of bacterial and viral nature in animals. Preparation has pefloxacin-mesylate and midantan at ratio 1:1. Preparation shows virus-static, bacteriological and bactericidal effect. Abactan is used at the dose 10-20 mg/kg body mass by parenteral or peroral route, once per 24 h for 3-10 days. EFFECT: enhanced effectiveness of preparation. 3 tbl
The canines, 2nd premolars, 1st molars and 2nd molars were bonded and banded. Leveling and alignment was achieved. After the first premolar extraction, temporary anchorage devices were inserted interradicular between 2nd premolar and 1st molar. Canine retraction was performed on a 0.016" X 0.022" stainless steel arch wire. A power arm was extended to apply the force closer to the center of resistance and achieve bodily movement. Elastomeric chains were calibrated to deliver a force of 150g and extended from the power arm to the mini screws directly. Recruited patients were randomly allocated to four groups according to the duration between the elastomeric chain reactivation. Canine reactivation intervals were 2, 4, 6, or 8 weeks. Cone beam computed tomography was performed before canine retraction and after 6 months of retraction. Digital dental casts were taken before canine retraction and monthly for 6 months.
Venous thromboembolism (VTE) and stroke carry significant mortality and morbidity in cancer patients. Direct oral anticoagulants (DOACs) have been demonstrated to be effective for the treatment of VTE and prevention of stroke in atrial fibrillation (AF). Bleeding rates are variable and are based on the cancer type and the patient's specific risk factors. There are approved specific antidotes for DOAC-associated bleeding. Other strategies are available for bleeding reversal, including the use of prothrombin complex concentrate (PCC). No randomized studies have compared head-to-head the efficacy and safety of reversal agents. We aim to examine the safety and effectiveness of hemostatic agents in cancer patients with DOAC-related major bleeding. A retrospective chart review study of patients at MD Anderson Cancer Center with DOAC-related major bleeding between 2014 and 2019. Bleeding severity and clinical hemostasis were described based on ISTH guidelines and the Sarode criteria, respectively. The rates of thrombotic complications and mortality at 30-day from the index bleeding event were described. We identified 23 patients with DOAC-related major bleeding; 14 patients received PCC and 9 patients received andexanet alfa. The most common sites of bleeding were the gastrointestinal tract and intracranial. Effective hemostasis and 30-day mortality were similar to reported results from other reports of outcomes of reversal agents for DOAC related-bleeding in non-cancer patients. One patient in each treatment group experienced a thrombotic event. Further larger scale studies are needed to confirm our findings in cancer patients.
Subjects will receive 3 single ascending oral doses (SAD) of GSK3186899 and 1 dose of placebo as spray dried powder, under fasted conditions on Day 1 of cohort 1 in each of the four treatment periods. In each treatment period GSK3186899 and placebo will be administered in a 3:1 ratio. A wash out period of at least 10 days will be maintained between each treatment period.
A method for the preparation of an active plant substance comprises peeling and washing cabbage (<I>Brassica oleracea var. capitata L.</I>), cutting it, cooling and freezing slices, defrosting the resulting material, refreezing, vacuum freeze drying, disintegration of the resulting material, extracting with water, separating the liquid part from insoluble fractions and vacuum freeze drying of the liquid part. Preferably, all the steps are carried out below 4 {C and the cooling and freezing slices step takes place at -27 to -40 {C for 12-36 hours. The active substance may be used for the prophylaxis and treatment of gastrointestinal distress and may be administered as a pharmaceutical composition or in a foodstuff, such as a confection. The substance may also be used to stimulate microbiological processes. The method provides a concentrated form of an unstable component, different from vitamin U, which provides the therapeutic activity of cabbage juice.
Asthma may deteriorate acutely over a period of hours or chronically over several days or longer. It is important to watch for signs of worsening asthma, such as increasing use of inhaled, short-acting beta2-adrenergic agonists or a significant decrease in peak expiratory flow (PEF) or lung function. Such findings require immediate evaluation. Patients should be advised to seek immediate attention should their condition deteriorate. Increasing the daily dosage of FORADIL AEROLIZER beyond the recommended dose in this situation is not appropriate. FORADIL AEROLIZER should not be used more frequently than twice daily (morning and evening) at the recommended dose.
The application discloses a medicine for treating 'milk disease' of river crabs, a using method and application. Comprises the following medicaments: the medicine is at least one of dithiocyano-methane, benzalkonium bromide, glutaraldehyde and benzalkonium bromide solution of glutaraldehyde; dithiocyano-methane, benzalkonium bromide, glutaraldehyde and benzalkonium bromide solution of glutaraldehyde are all aquatic drugs. The medicine is as follows: the dithiocyano-methane and benzalkonium bromide are combined according to the volume ratio of 1: 1-5. The medicine is as follows: the dithiocyano-methane and the glutaraldehyde are combined according to the volume ratio of 1: 1-5. The medicine is as follows: benzalkonium bromide and glutaraldehyde are combined according to the volume ratio of 1: 1-5. The medicine is as follows: the dithiocyano-methane and the glutaraldehyde benzalkonium bromide solution are combined according to the volume ratio of 1: 1-5. The medicine is as follows: the dithiocyano-methane, the benzalkonium bromide and the glutaraldehyde are combined according to the volume ratio of 1: 1-5; the invention can be used for well treating the 'milk disease' of the river crabs.
PURPOSE:To obtain a hairdressing material, capable of blackening the skin on of thinly-haired parts, making the thinly-haired parts inconspicuous and simultaneously carrying out hairdressing and hair growth by mixing a liquid material with a carbon fiber member. CONSTITUTION:A hairdressing material obtained by mixing a liquid material (especially preferably mixed with a substance containing fats and oils ingredients and a vitamin ingredient) with a black fiber member. The above-mentioned hairdressing material can be applied to hair using a brush to blacken parts of thin hair and simultaneously carry out hairdressing and hair growth. The black hair member is not scattered even if a brush or comb is used in setting hair without fouling clothes or interior of rooms. Since a material of fats and oils is used as the liquid material, the black carbon fiber member can be readily applied and hair can be simultaneously and readily set to a suitable hairstyle. The powdery carbon fiber member can be readily washed away simply by washing hair without any fear of causing stuffiness of the head part and the hairdressing material is extremely sanitary.
A total of one hundred participants were enrolled for the study. All individuals were assessed clinically and radiographically. Full-mouth clinical periodontal examinations were performed by the measurements of probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI) and bleeding on probing (BOP). All these measurements were recorded at six sites around each tooth with a manual periodontal probe. The participants were categorized into three groups: healthy controls (n=25), patients with gingivitis (n=25) and patients with periodontitis (n=50). Gingival crevicular fluid, saliva and serum samples were collected from each participant one day after the clinical periodontal measurements. TFF-1, TFF-3 and IL-1β levels of these biofluids were determined using the enzyme-linked immunosorbent assay.
The present invention provides a use of a  Physalis angulata Linn.  fruits extract for enhancing the gene expression level of  TGM , and/or  KRT . The  Physalis angulata Linn.  fruits extract can form more moisturizing factors on the skin and maintain the integrity of the stratum corneum to enhance the skin barrier function. The Physalis angulata Linn. fruits extract can effectively increase the activity of the mitochondria to maintain the normal metabolism and anti-aging activity of the skin. The Physalis angulata Linn. fruits extract is prepared by extracting  Physalis angulata Linn.  fruits using water, alcohols, or mixtures of water and alcohols as solvents.
Participants randomized to receive rucaparib plus nivolumab in 4 week cycles. Participants will receive rucaparib alone in cycle 1 and begin nivolumab on day 1 of Cycle 2.
The invention discloses a preparation method of a bromhexine hydrochloride glucose injection. The preparation method comprises the following steps: dissolving glucose by part of water for injection in a concentrated mixing tank, adding hydrochloric acid to adjust the pH value to 3.8-4.3, adding active carbon which is 0.01-0.1% (g/ml) in general volume, boiling for 10-20 minutes, and filtering and removing carbon to obtain a glucose concentrated liquid; and fully infiltrating bromhexine hydrochloride in prescription amount by water for injection and adding into the glucose concentrated liquid, stirring to dissolve and set the volume to obtain a diluted liquid, and after uniformly mixing, filling, carrying out moist heat sterilization, detecting by lamps and packaging. Compared with other methods of firstly dissolving bromhexine hydrochloride by acid or ethanol and then adding into the glucose concentrated liquid, the preparation method disclosed by the invention is simple, and bromhexine hydrochloride glucose is fully dissolved. Use of ethanol is avoided, so that adverse effects which can happen in clinical use can be avoided. Incomplete dissolution of main medicines and rise of related substances after bromhexine hydrochloride is dissolved by acid in conventional method are avoided. The prepared bromhexine hydrochloride glucose injection is low in content of related substances, and the quality and stability of the product are improved.
In this arm, participants will wear their clinically prescribed dynamic response foot. This period is 2 weeks long.
The invention relates to a preparation method and process for antibacterial modification of ceramic whiskers and in particular provides a preparation method for fusion-coating of zinc oxide nanoparticles having different patterns on the surface of hydroxyapatite whiskers. The preparation method is characterized by adding dropwise an ethanol solution of a zinc salt into a beaker in which an ethanol solution of hydroxyapatite whiskers is held, performing stirring, rotating, ultrasonic treatment, drying and calcination procedures to make zinc oxide-hydroxyapatite whiskers. The ceramic whiskers have antibacterial effects. The zinc oxide nanoparticles have good antibacterial effects and the antibacterial rate against Streptococcus mutans reaches (93.58 plus or minus 5.95) percent; and the hydroxyapatite whiskers have high strength. After modification, zinc oxide nanoparticles, nanospheres, nanorods, microspheres and diamond-shape units are uniformly distributed on the surface of the hydroxyapatite whiskers by fusion coating, the particle size is 30 nm to 400 nm, the surface area and the roughness are greatly improved, and the mechanical embedment force between the zinc oxide nanoparticle and the matrix is increased. Therefore, the zinc oxide-modified hydroxyapatite whisker can serve as an ideal reinforcing material with antibacterial effect.
NAFLD is the most common form of liver disease in children in the United States. Currently, there is no treatment for NAFLD. In adults, weight loss through caloric restriction is commonly recommended to improve fatty liver. Weight loss is particularly difficult for children to achieve and significant caloric restriction may not be a prudent recommendation in developing children and adolescents. Because of this difficulty with weight loss in children, many children go on to develop cirrhosis and eventually undergo liver transplant. Data on the effectiveness of diet to reverse fatty liver and prevent progression to cirrhosis in children is urgently needed. To date, no studies have been done examining how changes in diet composition without intentional caloric restriction influences NAFLD in children. Data from previous studies in adults support the hypothesis that consumption of lower-CHO, higher-fat food sources rich in high-quality proteins and essential fatty acids has beneficial effects on metabolic health in adults without restricting calories. This study aims to test the hypothesis that a low CHO higher- fat diet will induce rapid reversal of fatty liver while also depleting of total and abdominal adiposity, preserving lean mass, and reducing inflammation in adolescents with obesity and NAFLD.
B-cell lymphomas express on their surface an immunoglobulin containing unique idiotypic determinants (idiotype) which can be used as specific tumour markers. The applicant produced monoclonal murine antibodies (MAbs) reactive with the idiotype marker derived from 67 patients with a low level of follicular, small cleaved cell lymphoma. Of 199 monoclonal antibodies, 47 (24%) reacted with a mixture of normal human serum immunoglobulin at concentrations ranging between 0.6 μg/ml and 160 μg/ml.  Of these 40 monoclonal antibodies, 90% give a cross reaction with idiotype present in normal serum at levels < 50 μg/ml.  Thirty- two of these anti-idiotypes were directed against a shared idiotope expressed in other cells from a patient with lymphoma.  The frequency of expression of the shared idiotope defined by each antibody varied between 0.26% and 3.9% of the B-cell lymphomas tested.  A panel of five anti-idiotype antibodies reacted with 80% of the lymphomas associated with AIDS. Based on the reactivity with these monoclonal antibodies, the tumours could be grouped in distinct families.  In aggregate, these 32 monoclonal antibodies reacted with a total of 108 of 332 cases of B-cell lymphomas (32.5%), including 35 of 1/6 follicular, small cleaved cell lymphomas (30%).  Many of these shared anti-idiotopes reacted with more than one histopathological subtype of lymphoma. The anti- idiotypes have been used in the diagnosis and treatment of B-cell lymphomas.  Furthermore, the applicant discovered at least seven anti-shared idiotype antibodies which give a cross reaction with auto-antibodies, e.g. 16.6 and RF.  The development of a library of anti- idiotypes that are reactive with shared idiotopes will make it possible for these clinical studies to obviate the need to develop a specific hybridoma for each patient.
OBJECTIVES: To describe voice and airway outcomes and complications experienced by patients with laryngotracheal stenosis following Montgomery T-tube placement.
METHODS: Retrospective chart review of all patients with laryngotracheal stenosis and Montgomery T-tube placement treated at a tertiary referral center from 2012 to 2021.
RESULTS: Eighteen patients met criteria with laryngotracheal stenosis, seven including the level of the glottis and 11 without glottal involvement. Eleven were completely aphonic before T-tube placement and the remainder had severe dysphonia. There was improvement of Voice Handicap Index-10, Reflux Symptom Index, and GRBAS grade following T-tube placement in patients compared to their preoperative values. Improvement of grade was greater in patients without glottal involvement. Complications of chronic indwelling T-tube included granulation in 14 patients (78%), tracheitis in two patients (11%), and mucus plugging in three patients (17%) with one T-tube related mortality. Five patients were eventually decannulated, six returned to tracheostomy tube, and seven retained the T-tube at last follow-up (average: 30 months, range: 4-80 months).
CONCLUSIONS: Montgomery T-tube placement improves voice in patients with severe dysphonia secondary to laryngotracheal stenosis with and without glottal involvement though the degree of improvement is greater in patients without glottal involvement. T-tube can help reestablish long-term laryngotracheal continuity in patients with no other surgical options. The potential benefits in phonation should be weighed against the possibility of rare but serious adverse events.
The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans. These strains combine the two most important properties of live attenuated cholera vaccine candidates. One such property is being well tolerated by people ingesting them. This was achieved by virtue of mutations already described in the art. The second property is having enhanced environmental safety due to the absence of VGJ.PHI. DNA in their genomes and also due to null mutations in the mshA gene or other spontaneous mutations conducive to the lack of MSHA type IV fimbria on the bacterial surface. This was done envisioning that VGJ.PHI. is a filamentous phage able to recombine with CTX.PHI. and disseminate the cholera toxin genes. This VGJ.PHI. phage as well as the VGJ.PHI.-CTX.PHI. recombinants uses the MSHA fibers as receptor. Being devoid of MSHA fimbria the vaccine candidates are protected from acquiring CTX.PHI. from the recombinant hybrid VGJ.PHI.-CTX.PHI.. Being devoid of VGJ.PHI., the vaccine candidates are impaired in the dissemination of CTX.PHI., via VGJ.PHI..
A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt of a Group I element (for example, NaCl) to form a dispersion containing polyphosphazene coacervate microdroplets. The dispersion then is admixed with a solution containing a salt of a multivalent ion, such as a salt of a Group II element (for example, CaCl 2 ) to form a suspension of polyphosphazene microspheres. The polyphosphazene microspheres then are recovered from the suspension. Such method enables one to obtain high yields of microspheres having a controlled size distribution. Polyphosphazene microspheres containing biological material can be produced by providing a biological material in the polyphosphazene solution that is mixed with the solution containing a salt of a monovalent ion. The biological material may be an antigen or other biological material selected from proteins, nucleic acids, polysaccharides and synthetic compounds having biological activity.
PURPOSE:To provide a herb tea preparable safely and easily in the home, and having the drug action such as cholesterol-lowering action, etc., by culturing basidiomycete such as Cortinellus shiitake in a solid medium rich in xylose component, and using the obtained mycelia as main component. CONSTITUTION:The objective herb tea is prepared by culturing a basidiomycete in a solid medium rich in xylose component (e.g. bagasse, straw, etc.), and using the obtained cultured mycelia as a main component. The tea has drug actions such as hypolipemic, GPT-lowering and blood sugar level lowering actions, etc. It is supposed that the excellent drug actions are caused by glycoproteins and N-containing low-molecular substances mainly originated from the xylose component.
Patients in this group will be randomly allocated to sit in standard position first.Ultrasonography will be performed in this position to measure the best visualized length of posterior longitudinal ligament, ligamentum flavum and interlaminar distance at L3-4 lumbar level as by Operator 1 . These measurements will be recorded by Operator 2 using intrinsic caliper software.Operator 1 will not be told the measurements.