anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Mesenteric panniculitis (MP) represents the uncommon, benign and chronic inflammatory disorder affecting the mesenteric adipose tissues. Its etiology, diagnosis and treatment remain unnoticed. Our report focused on shedding more lights on this condition.
PATIENTS AND METHODS: Seventeen MP patients were identified by searching the electronic medical record system in the Zhengzhou Ninth People's Hospital using the search terms "Mesenteric panniculitis" from October 2015 to March 2023. All cases were diagnosed with MP through computed tomography (CT). Their clinical features and treatments were analyzed.
RESULTS: There were altogether 17 cases enrolled for this analysis. The male to female ratio was 8:9, and the median age at diagnosis was 64 (range: 37-96) years. There were 15 patients (88.2%) showing abdominal pain to varying degrees. The proportions of symptoms of nausea, vomiting and fever were 23.5%, 23.5% and 41.2%, respectively. Neoplastic disease was present in 3 patients (17.6%). Meanwhile, 9 patients (52.9%) had gallstones, 3 (17.6%) had cholecystitis and 1 (5.9%) had gallbladder polyps. Six patients (35.3%) received antibiotics treatment only and 1 (5.9%) received oral antibiotics and prednisone. One patient (5.9%) received antibiotics followed by prednisone treatment, because the symptoms were significantly relieved after antibiotic treatment, while the disease recurred soon after, and the symptoms improved again after prednisone treatment. The abdominal pain in 9 patients (52.9%) was relieved spontaneously. Two patients (11.8%) died, including one due to respiratory failure caused by pneumonia and the other one because of pancreatic cancer with lung and liver metastases.
CONCLUSION: MP is a poorly understood chronic inflammatory disease. Patients often have abdominal pain as the main symptom, accompanied by comorbidities in the gallbladder, and the prognosis is usually good after correct diagnosis and treatment, Therefore, the present report aims to promote the awareness among clinicians of patients with non-classic abdominal symptoms, so as to avoid misdiagnosis or missed diagnosis.
Patients were equally allocated into two groups i.e. Group A \& Group B by lottery method. In both groups, the lower bowel was emptied by an enema about an hour before the operation. All patients in Group A underwent the loose seton technique. The procedures were performed in the operating room with the patient in the lithotomy position. Probing of the fistula tract was done with a metallic malleable probe. The incision was given from the external opening of the fistula to the anal verge, involving the skin, subcutaneous tissue, superficial part of the external sphincter, and superficial part of the internal sphincter. After the insertion of loose Seton, a non-absorbable suture was left loosely and kept in situ for three months.

In group B, video-assisted fistula tract surgery (VAAFTS) was performed. The patients were positioned in the lithotomy position. The fistuloscope was then introduced into the external opening and the procedure was performed, except for the closure of the internal opening, which was performed with either a "figure of eight" suture or an advancement flap, rather than using a stapler. The tracts were destroyed using electrocautery, the necrotic tissues were removed, and the external openings were cored out and left open for drainage. The patients were discharged the day following the procedure. Twice daily Sitz baths, analgesics, and stool bulking agents (bran) were used in follow-up care. Repeated examinations were carried out every four weeks and recurrence was noted at the end of three months. The information (age, gender, duration of disease, BMI, diabetes mellitus, hypertension, place of living, and recurrence) was collected through pre-designed Performa (Annexure I).
PURPOSE: A composition for preventing or treating angiosteosis mediated diseases including zinc is provided to be effective for suppressing or alleviating angiosteosis by suppressing apoptosis of the vascular smooth muscle cells. CONSTITUTION: A composition for preventing or treating angiosteosis mediated diseases including zinc includes less than 3-5 microM of zinc. The disease is osteoporosis, breast cancer, pigment artery scleroma, nephropathy, diabetes, late-stage renal failure or thyroid cancer. The composition controls apoptosis of the vascular smooth muscle cells. The composition controls the angiosteosis. The pharmaceutical composition for preventing the angiosteosis mediated diseases includes zinc as an active ingredient. The composition includes a pharmaceutically allowed carrier. A Quasi Drug composition which suppresses or alleviates the angiosteosis includes the zinc as an active ingredient.
Patients of these group will be the control group. The will receive acetaminophen 1g every 8h, ketorolac 30mg ever 12h and as required morphine 2mg for post operative analgesia after hip arthroplasty.
The invention discloses a preparation method of traditional Chinese medicine health-care food for treating iron deficiency anemia, relating to a preparation method of traditional Chinese medicine health-care food and solving the problem that the angelica sinensis polysaccharide content obtained by using the existing method for preparing the angelica sinensis polysaccharide is low. The method comprises the following steps: I. extracting the angelica sinensis polysaccharide; II. refining the angelica sinensis polysaccharide; III. preparing the angelica sinensis polyferose; and IV. preparing the angelica sinensis polyferose capsules. The preparation method is simple, and the content of the angelica sinensis polysaccharide extracted is up to 81.3%; the traditional Chinese medicine health-care food for treating iron deficiency anemia has high iron content, is similar to ferritin in molecular structure, and can be absorbed by intestinal mucosa in a molecular manner, thereby being high in bioavailability; and no free Fe<2+> and Fe<3+> ions are formed, no obvious stimulation to the mucosa of digestive tract exists, and no adverse effect on the digestive tract exists after the traditional Chinese medicine health-care food is orally taken.
BACKGROUND: The relationship between sedentary time, physical activity, and chronic back pain remains unclear. The study aims to investigate whether sedentary time and physical activity predict chronic back pain and morphological brain changes.
METHODS: This cohort study recruited adults aged 37-73 years enrolled between 2006 and 2010, with follow-up until 2014. The total cohort comprised 33,402 participants (mean age: 54.53). Data were collected on daily sedentary time, physical activity, lifestyle factors, and health outcomes.
RESULTS: After nearly 8-year follow-up, 3,006 individuals (9.00%) reported chronic back pain in total. Individuals with daily sedentary time exceeding 6 h had a 33% higher risk of chronic back pain compared to those with sedentary time of 2 h or less (RR, 1.33, 95%CI, 1.17-1.52). Sedentary time was also associated with decreased grey matter volume in several brain regions, including bilateral primary somatosensory cortex (S1), secondary somatosensory cortex, putamen, primary motor cortex (M1), insula, hippocampus, amygdala, as well as right supplementary motor area, left medial frontal cortex, and right anterior cingulate cortex (FDR-corrected p-value < 0.05). Compared to individuals who sat for more than 6 h with light physical activity, those engaging in moderate physical activity with sedentary time of 2 h or less (RR, 0.71, 95%CI, 0.52-0.99) exhibited a significant decrease in chronic back pain risk. In addition, replacing sedentary time with equivalent amount of physical activity also demonstrated a reduction in the risk of chronic back pain (RR, 0.87, 95%CI, 0.77-0.99) and increased the reginal grey matter volumes including the amygdala, insula, M1, putamen and S1.
CONCLUSIONS: Prolonged sedentary time is associated with heightened risks of chronic back pain and deterioration in brain health.
The invention discloses a traditional Chinese medicinal composition for treating nephrosis and an application method thereof and belongs to the field of traditional Chinese medicines. The traditional Chinese medicinal composition comprises the following components: coptis root, poria cocos, radix scutellariae, cordate houttuynia, Gorgon fruit, wolfberry fruit, white peony root, spreading hedyotis herb, rhubarb, radix rehmanniae preparata, stir-baked rhizoma dioscoreae, the bark of eucommia, fructus forsythiae, Herba Andrographis, Herba Scutellariae barbatae, bighead atractylodes rhizome, safflower, herb of herba cirsii, radix astragali, phellodendron bark, cassia twig, figwort root and platycodon grandiflorum. The above medicinal materials are added into 6-10 times of water to be immersed for 20-40 min; boiling with high heat is carried out; decoction is carried out with gentle heat for 30-60 min, and decoction is repeated for 2-3 times; medicinal solutions are finally merged, and the merged medicinal solution is divided into three parts to be taken for three times. According to the traditional Chinese medicinal composition, the medicinal composition is carefully chosen under the guidance of traditional Chinese medicine theory and clinical experience. The traditional Chinese medicinal composition has a peculiar effect in treating nephrosis. In addition, medicinal herbs resources are wild, and costs are low.
Atrial fibrillation (AF) is a common arrhythmic complication in cancer patients and can be exacerbated by traditional cytotoxic and targeted anticancer therapies. Increased incidence of AF in cancer patients is independent of confounding factors, including preexisting myocardial arrhythmogenic substrates, type of cancer, or cancer stage. Mechanistically, AF is characterized by fast unsynchronized atrial contractions with rapid ventricular response, which impairs ventricular filling and results in various symptoms such as fatigue, chest pain, and shortness of breath. Due to increased blood stasis, a consequence of both cancer and AF, concern for stroke increases in this patient population. To compound matters, cardiotoxic anticancer therapies themselves promote AF; thereby exacerbating AF morbidity and mortality in cancer patients. In this review, we examine the relationship between AF, cancer, and cardiotoxic anticancer therapies with a focus on the shared molecular and electrophysiological mechanisms linking these disease processes. We also explore the potential role of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in the management of anticancer-therapy-induced AF.
Compression therapy of the leg is a proven and well-established modality to prevent deep vein thrombosis in immobilized and post-surgical patients. The investigators aim to compare a new sequential compression for the leg that utilizes a servo motor for compression as opposed to a traditional pneumatic motor that is typically used in the hospital and after surgery. Pneumatic sequential compression devices are cumbersome, expensive and not mobile. This new compression device was developed to provide a cheaper, mobile device that can be worn by the patient after surgery and while at home during ambulation. The addition of the servo motor and fine sensors may also be able to detect sub-clinical DVT's that contribute to post-surgical pulmonary embolus and post-surgical complications. The investigators aim to learn how this new device performs in the subset of patients undergoing complex spine surgery, the incidence of post-surgical DVT with this new device compared to traditional SCD and if this new device is capable of detecting sub-clinical post-surgical DVT.
Oil compsns for prepn. of cosmetic skin-care creams on the basis of normally used solids, emulsifiers, additives such as antioxidants, preserving agents, perfumes, etc. are improved by addition of 0.2-25 wt % (pref 2-20 wt %) of a salt(s) of isostearic acid(s), pref with ammonia, lower amines or lower alkanolamines, esp. mono-, di- or trialkanolamines, which stabilises the viscosity of the skin cream at the desired level. If the pH of the cream is about 4, the isostearic acid salt should be combined with an ethylene oxide-fatty alcohol adduct as a non-ionic emulsifier (15-30 wt % w.r.t. the oil compsn).
Patients receive futibatinib PO QD on days 1-28 and durvalumab IV over 60 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients then undergo radical cystectomy within 4-12 weeks. Patients also undergo CT and MRI during screening and on the trial and also undergo blood sample collection on the trial.
Hernia inguinal repair is the most common operation performed by general surgeons in the Netherlands. On of the most common complications after hernia repair is postoperative and chronic pain. Postoperative pain is an expected but undesirable effect after an operation, which can result in an prolonged hospital stay or longer time to return to full normal daily activities. There are indications that an insufficient treatment of postoperative pain is a risk factor for persistent or chronic pain after open inguinal hernia repair. Chronic pain is not uncommon after hernia repair, with an incidence of 11%.

The objective of this study is to determine, whether the use of an perioperative echo guided unilateral TAP block has an superior effect on postoperative pain after open hernia inguinal repair compared to wound infiltration with a long acting local anesthetic. There will be no further analysis in this study regarding the incidence of open hernia inguinal repair and chronic pain.
During the first week, all three main meals were replaced with 50 g of a protein-rich meal replacement (Almased) (=1100 kcal per day). During weeks 2-4, only two meals were replaced and a protein-rich lunch was allowed. During weeks 5-12, only dinner was replaced.
Design Overview. Following a 1 week home baseline, N=36 young adults will spend 6 days in the laboratory (Figure 3 and Table 1). Following am 8 h baseline polysomnographic recording (PSG) on Night 1, participants will undergo a 26 h baseline circadian assessment via an ultrashort sleep-wake protocol involving 2 h wake intervals and 1 h sleep intervals, repeated throughout the protocol. Following baseline circadian assessment, participants will be placed on a 16 h wake-8 h sleep schedule in which the wake-sleep and light-dark schedule is delayed 8 h for 3 days (analogous to traveling 8 time zones west). Participants will be randomized to one of 3 treatments (n=12 per treatment) administered each of the 3 days of the shifted schedule: (1) placebo control, (2) bright light, and (3) bright light + exercise + melatonin. PSG recording will occur on the last night of the shifted schedule, followed by an end-of-study 26 h ultrashort sleep wake schedule. On baseline Day 1 and Days 2-3 of the shifted schedule, sleepiness, mood, and mental performance will be assessed every 3 h during wake. During all four 8 h sleep periods, sleep will also be recorded with the Z-machine, which assesses sleep stages from 3 EEG electrodes. During the ultrashort sleep-wake schedules, mental performance, physiological performance, urinary aMT6s, mood, and sleepiness will be measured around-the-clock.
A system and method for protecting sensitive information, for example, a user's personal information, stored on a database where the information is accessible via a communications network such as the Internet. An exemplary embodiment stores the sensitive information on an off-line server. The off-line server is connected to an on-line server. The on-line server is connected to the user via the Internet. The user interfaces with the on-line server, and at a scheduled time window, the sensitive information is made available to the on-line server by the off-line server. Outside of the time window, none of the sensitive information is kept on the on-line server. Thus by placing the sensitive information on-line for only limited periods of time the risk of compromise to the sensitive information is greatly reduced.
Group A will consist of sequence of treatment with 3 stimulation modes. They are, in order, 1000 hertz, standard, and burst stimulation. Each stimulation modes will last 3 weeks, with 4 days of wash off between them. Each group treatments will take about 3 months, and subject will cross over into the other treatment group. Burst stimulation sends packets of electrical pulses, composed of pulse and packet frequency. 1000 hertz stimulation delivers tonic, sub perception stimulation. The standard stimulation mode, which will serve as the control, will be below 100 hertz, and its pulse strength will be above threshold, where patients will feel the tingling from the electrical pulses generated by the spinal cord stimulator.
The 'lower volume' (LV) fluid bolus arm will receive a continuous background infusion of 4% dextrose in 0.18% NaCl at 50ml/hr for the entire 4 hour rehydration period. Subjects will be given a hand-held trigger, which when pressed will deliver an additional volume of fluid from the infusion pump; this will be administered over a 10-minute period (thus allowing a maximum of 6 boluses per hour). In the LV arm, the trigger will deliver 50mls over 10 mins at a rate of 300ml h-1. A green LED will signal to the patient that no additional infusion is running, and that pressing the trigger will activate delivery of another bolus. The volume and lockout periods for the boluses may vary but will remain within the maximum fluid administration of 1200mls per hour.
C2H2 zinc effectors are a class of pathogen proteins that play a dual role in plant-pathogen interactions, promoting pathogenicity and enhancing plant defense. In our previous research, we identified Magnaporthe oryzae Systemic Defense Trigger 1 (MoSDT1) as a C2H2 zinc effector that activates rice (Oryza sativa) defense when overexpressed in rice. However, its regulatory roles in pathogenicity and defense require further investigation. In this study, we generated an MoSDT1 overexpressing strain and 2 knockout strains of M. oryzae to assess the impact of MoSDT1 on pathogenicity, rice defense, and phenotypic characteristics. Our analyses revealed that MoSDT1 substantially influenced vegetative growth, conidia size, and conidiation, and was crucial for the virulence of M. oryzae while suppressing rice defense. MoSDT1 localized to the nucleus and cytoplasm of rice, either dependent or independent of M. oryzae delivery. Through RNA-seq, scRNA-seq, and ChIP-seq, we identified that MoSDT1 modulates rice defense by regulating the phosphorylation and ubiquitination of various rice signaling proteins, including transcription factors, transcription repressors, kinases, phosphatases, and the ubiquitin system. These findings provide valuable insights into the regulatory mechanisms of C2H2 zinc finger effector proteins and offer important foundational information for utilizing their target genes in disease resistance breeding and the design of targets for disease management.
The invention discloses a preparation method of an immunologic adjuvant, which comprises the steps of taking freeze-dried BCG vaccine and freeze-dried polyinosinic-polycytidylic acid dry powder, grinding the freeze-dried BCG vaccine and the freeze-dried polyinosinic-polycytidylic acid dry powder in a mortar until no granular solid exists, taking paraffin oil and Span80, pouring the paraffin oil and the Span80 into a container, uniformly stirring, standing, filtering, adding the ground no granular solid into filtrate, uniformly stirring, subpackaging and warehousing. In the invention, the Span80 is used for replacing lanolin, so that the appearance is bright and the stability is increased. The volume ratio of Span80 is improved, the emulsifying time is shortened, and the immune reagent can keep a water-in-oil state for a long time after emulsification. The inactivated mycobacterium tuberculosis is replaced by safer bacillus calmette-guerin, and the biological safety of the complete adjuvant is improved. The final concentration of BCG vaccine is 5mg/ml, and the immune reaction of the immunological reagent in animal body can be improved. The newly added 5mg/ml polyinosinic cell and the BCG form a synergistic effect in the animal body, and can improve the immune response of the immune reagent in the animal body.
<P>PROBLEM TO BE SOLVED: To provide fermented milk having new function of relation with I-type allergy clarified on scientific grounds, and to provide fermented milk production spawn to be used for producing the fermented milk.  <P>SOLUTION: The fermented milk contains the fungus body or fungus body component of a plurality kinds of lactic acid bacteria composed of Lactobacillus casei, Lactobacillus plantarum, Lactococcus lactis subsp. lactis, and Lactococcus lactis subsp. cremoris. It is possible to induce interferon-gamma expression and adjust Th1/Th2 balance to Th1 domination by daily eating the fermented milk. As a result of this, generation of IgE is inhibited to inhibit appearance of I type allergy. The fermented milk production spawn to be used for producing the fermented milk contains the lactic acid bacteria.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Eccentric training of the upper trapezius muscles. The intervention will consist of ten sessions of 25-30 minutes (twice a week over 5 consecutive weeks) of eccentric exercises of the shoulder muscles, as neural activation increases after 4 weeks of eccentric training. The total duration of the intervention will be 2 hours and a half.
Hyponatremia may occur as a result of treatment with antidepressants. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Cases with serum sodium lower than 110 mmol/L have been reported. Elderly patients may be at greater risk of developing hyponatremia with antidepressants. Also, patients taking diuretics or who are otherwise volume-depleted can be at greater risk. Discontinuation of trazodone hydrochloride tablets should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted.

Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which can lead to falls. Signs and symptoms associated with more severe and/or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death.
PURPOSE: To conduct a scoping review on five individual social determinants of health (SDOHs): gender, education, ethnicity, socioeconomic status, and social support, in relation to post-stroke aphasia outcomes.
MATERIALS AND METHODS: A comprehensive search across five databases was conducted in 2020 and updated in 2022. Twenty-five studies (3363 participants) met the inclusion criteria. Data on SDOHs and aphasia outcomes were extracted and analysed descriptively.
RESULTS: Twenty studies provide information on SDOH and aphasia recovery outcomes. Five studies provide insights on SDOH and response to aphasia intervention. Research on SDOH and aphasia recovery has predominantly focussed solely on language outcomes (14 studies), with less research on the role of SDOH on activity, participation, and quality of life outcomes (6 studies). There is no evidence to support a role for gender or education on language outcomes in the first 3 months post stroke. SDOHs may influence aphasia outcomes at or beyond 12 months post onset.
CONCLUSIONS: Research on SDOHs and aphasia outcomes is in its infancy. Given SDOHs are modifiable and operate over a lifetime, and aphasia is a chronic condition, there is a pressing need to understand the role of SDOHs on aphasia outcomes in the long term.