anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of this study was to evaluate the quality of life, pelvic discomfort, and sexual function of patients who underwent posterior pericervical repair or level I to III surgical procedures for pelvic organ prolapse (POP) after 5 years of follow-up. This retrospective cohort study enrolled 107 women with POP who were referred to the Imam Khomeini Hospital Complex, an academic center affiliated with the Tehran University of Medical Sciences, Tehran, Iran, from 2014 to 2021. The patients underwent transvaginal surgery using native tissue, in which the rectovaginal fascia was attached to the pericervical ring. The Pelvic Floor Distress Inventory-20 (PFDI-20) and Lower Urinary Tract Symptoms Module (ICIQ-FLUTSsex) questionnaires were completed by each patient before and 5 years after surgery. Of the 107 patients, only 78 completed the 5-year follow-up. The mean PFDI-20 scores before, 12 months, and 5 years after surgery were 141.87 ± 34.48, 100.87 ± 26.48, and 37.49 ± 56.39, respectively, indicating a significant improvement in the patients' symptoms after surgery (P < 0.001). The total mean score of ICIQ-FLUTSsex was 3.67 ± 3.63 (range, 0-10). In total, 22 (28.2%) women had an ICIQ-FLUTSsex score of 0, indicating no problems. The attachment of the rectovaginal fascia to the pericervical rings can be an effective surgical technique for correcting posterior vaginal wall prolapses, without significant morbidity. The PFDI-20 score improved significantly from before surgery to 12 months and 5 years after surgery.
The escalating phenomenon of migration, accompanied by a disturbing surge in associated tragedies, has persistently violated internationally protected human rights. Absence of physical evidence, namely the presence of adequately identified corpses, may impede the full enjoyment of human rights and-in some cases-the course of justice as it obstructs the initiation of legal proceedings against individuals implicated in causing such catastrophes. It also presents administrative obstacles, as death certificates are indispensable in legitimizing statuses like orphanhood and widowhood. Family reunification, particularly for orphans, plays a significant role for those attempting to reconnect with their relatives all over the world. Likewise, for mothers, the acknowledgment of their marital status or widowhood can be a pathway to regain their marginalized right to social life. To elucidate this issue, we analyzed six representative cases from the tragic October 3, 2013, shipwreck near the Italian island of Lampedusa, where 366 individuals were retrieved dead from the sea. These cases underscore the practical challenges involved, highlighting the compelling need for continued efforts to ensure that this burdensome problem transcends from being a mere ethical, moral, and legal discourse. Although considerable progresses, these cases also reveal that substantial work still lies ahead. There is a pressing need for improved mechanisms to certify kinship ties, which are often the limiting factor in many reunifications, and can hinder the granting of custody to children. The severity and far-reaching implications of this problem necessitate thoughtful attention and action, especially considering the ongoing escalation in migration and related fatalities.
PURPOSE: Urinary tract infection (UTI) is the second most common indication for antibiotic therapy among inpatients in the United States. Ceftriaxone, a third-generation cephalosporin, is habitually chosen to treat inpatient UTIs due to familiarity, cost, and perceived safety. However, third-generation cephalosporins increase the risk of health care facility-onset Clostridioides difficile infection (HOCDI) more than any other antibiotic group, while no statistical risk exists for first-generation cephalosporins. Recent evidence comparing Enterobacterales susceptibility for first- and third-generation cephalosporins in urinary specimens in the United States is limited. This analysis assessed the comparative activity of cefazolin and ceftriaxone for Enterobacterales urinary isolates and incidence of HOCDI to determine the usefulness of cefazolin as an empirical agent to manage inpatient UTI and limit ceftriaxone collateral damage.
METHODS: This was a retrospective single-center observational study. Microbiologic susceptibility data were analyzed for Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis urinary specimens taken from adult inpatients admitted from January 1, 2022, to December 31, 2022. Primary outcome was incidence of E coli, K pneumoniae, and P mirabilis susceptibility to cefazolin in uncomplicated UTI (MIC <16 µg/mL). Secondary outcomes include susceptibility for complicated UTI and HOCDI risk associated with cefazolin and ceftriaxone.
FINDINGS: A total of 1150 urine samples were identified as E coli, K pneumoniae, and P mirabilis in 2022. Susceptibility to cefazolin was observed in 1064 (92.5%) of 1150 isolates using the MIC breakpoint for uncomplicated UTI and to ceftriaxone in 1115 (97.0%) of 1150 isolates (P < 0.001). From 2016 to 2022, either cefazolin or ceftriaxone was administered in 26,462 inpatient admissions, with HOCDI diagnoses occurring in 89 admissions. HOCDI developed in 78 admissions (0.40%) with ceftriaxone exposure, and 11 cases (0.15%) developed in cefazolin-exposed admissions (adjusted odds ratio, 2.44; 95% CI, 1.25-4.76; P < 0.001).
IMPLICATIONS: Cefazolin exhibits high susceptibility for uropathogens commonly implicated in cases of uncomplicated UTI, the most common UTI diagnosis among inpatients. Although ceftriaxone shows a higher susceptibility rate against these common uropathogens, it more than doubles the risk for HOCDI compared with cefazolin. For institutions evaluating opportunities to reduce ceftriaxone use to limit associated collateral damage such as HOCDI, use of cefazolin for uncomplicated UTI may be evaluated by using local susceptibility data.
PURPOSE:To obtain a squalene-containing composition useful as a nutrient assistant and pharmaceutical, etc., by adding a phospholipid to squalene, thereby stabilizing squalene. CONSTITUTION:Squalene is a compound having the chain structure of formula, high impregnation property and activation activity and exhibiting effective physiological action to gastric ulcer and hepatic diseases, however, it has poor stability and is liable to be easily decomposed with oxygen or heat owing to its highly unsaturated structure. The objective stabilized squalene-containing composition can be produced by compounding (A) 100pts.wt. of squalene with (B) preferably about >=1pt., especially about >=3pts.wt. of one or more kinds of phospholipids selected from phosphatidylcholine, phosphatidyl ethanolamine, sphingomyelin, etc., as a stabilizer for the component A and preferably further (C) preferably 1-10pts.wt. of an antioxidant, especially a natural antioxidant such as vegetable oil containing tocopherol.
Accepted acupuncture therapy after 10 days of the onset of Bell's palsy. The acupuncture points used were Dicang (ST4), Jiache (ST6), Yangbai (GB14), Xiaguan (ST7), Taiyang (EX-HN5), Quanliao (SI18) and Yifeng (TE17) on the affected side, and Hegu (LI4) bilaterally. Penetrative needling is used from Dicang (ST4) to Jiache (ST6) and from Taiyang (EX-HN5) to Quanliao (SI18) 2-3 cun, and routine puncturing is used at other acupoints 7 d after enrolment. Filiform needles (33 - 49.5 mm, 0.32 mm) will be used with moderate stimulation to get an acupuncture sensation, and the needles were retained for 30 minutes, once a day, five times a week, for a total period of four weeks.
An antibacterial substance is prepared by subjecting comminuted plant material of plants of the Cruciferae and Tropaeolaceae families to the action of water in the presence of an enzyme especially myrosin, which is capable of splitting up glycerides present in said plant material and which is present in the plant or is added thereto, for not more than two hours, adding a preservative such as benzoic acid to inhibit the enzyme, and extracting the fermented mixture with a mineral oil, an animal or vegetable oil or fat, or an organic solvent for fats.  The separated extract is used medicinally as such or when incorporated into soaps and pharmaceutical carriers including ointments.  It is preferred to carry out the aqueous fermentation in closed vessels to prevent loss of volatile oil.  Examples describe the extraction of the fermented mash of (a) Tropaeolum majus (Indian cress) with liquid paraffin (b) Cochlearia armoracia (horse radish) with peanut oil and (c) Lepidium sativum (garden cress) with sperm oil.  Other plants which may be used are: Brassica oleracea var capritata (cabbage), B. oleacea var. botrytis (cauliflower), B. oleacaea subvar gemnifera (Brussel sprouts), B. rapa, B. napus, B. oleracea subvar. sabauda, B. nigra, Raphanus sativus niger, R. sativus var. radicula, Sinapis alba, Alyssum, Arabis alpina, aubrietia alpina, aubrietia alfina, Aubrutia bougainvillea, Cherianthus allionii, Cochlearia officinalis, Hesperis matronalis, Iberis amara, Runaria biennis and Nasturtium officinalis.
The present invention relates to a preparation method of islet cell clusters (ICCs) with enhanced insulin secretion ability using the hanging-drop technique. The present inventors have optimized the size of ICCs by using the hanging-drop technique. The ICCs exhibited substantially improved viability in a hypoxic culture condition. Based on the result of confocal microscopic analysis, and the spatial configuration of islet singlet cells in the ICCs was identical to an intact islet cell. Expressions of various intracellular proteins related to intercellular interactions in islet cells were not much changed. More interestingly, in a diabetic animal, it was confirmed that the ICCs maintain a normal blood glucose level.
Hyponatremia can occur as a result of treatment with Carbatrol. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The risk of developing SIADH with Carbatrol treatment may be dose-related. Elderly patients and patients treated with diuretics are at greater risk of developing hyponatremia. Signs and symptoms of hyponatremia include headache, new or increased seizure frequency, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which can lead to falls. Consider discontinuing Carbatrol in patients with symptomatic hyponatremia.
The invention relates to an L-alanine and L-glutamic acid-5-benzyl ester polypeptide copolymer hydrogel and an application thereof. The polypeptide copolymer hydrogel is a block copolymer aqueous solution of nano silver-loaded polyethylene glycol and poly(L-alanine-co-L-glutamic acid-5-benzyl ester), and the concentration range is 50-300 mg/mL. Through adjustment of the content of alanine and glutamic acid-5-benzyl ester in a polypeptide chain segment, assembly and gel properties of the copolymer can be flexibly adjusted and controlled. The nano silver hydrogel dosage form has good in-vitro antibacterial effect. A polypeptide hydrogel antibacterial agent has the advantages of simple and convenient nano silver loading, high loading capacity, adjustable gel properties and the like. The polypeptide hydrogel as an auxiliary material of the antibacterial agent is applicable to antibacterial application of different in-vivo tissues and has potential application value in the biomedicine field.
Subcutaneous injection of 250 μg of OVITRELLE. 0.5 mL as a single dose.
Previous studies have demonstrated the connection between obesity and telomere length. A recently devised metric for determining obesity, the weight-adjusted-waist index (WWI), offers a distinct advantage in predicting fat and lean mass by depicting weight-independent abdominal adiposity. This article presents the results of the inaugural study on the relationship between WWI and telomere length in adult populations. The cross-sectional investigation analyzed data from 3479 participants from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2000. To inspect linear and nonlinear correlations, we adopted weighted multiple logistic regression analysis and smooth curve fit, respectively. In addition, threshold effects and subgroup analyses were accomplished. In the fully adapted model, a significant adverse association of WWI with telomere length was detected [β = -0.02, 95% CI: (-0.03, -0.00), P value = 0.01]. The adverse correlation remained consistent across all subcategories. We also discovered an inverted U-shaped curve linking WWI and telomere length, with a conspicuous inflection point of 10.07 cm/√kg. For the first time, our research demonstrated strong links between WWI and telomere length. The inflection point suggests that controlling WWI within an optimum range might be essential for aging and health.
Participants engage in 30-minute face-to-face communications with study staff through internet/webcam 4 times per week for 24 weeks (6 months). Under an exploratory aim, a limited number of participants will be further followed by sustaining dose of 2 times per week of 30 minutes session for additional 24 weeks (6 months). Conversational staff will facilitate content-standardized but naturalistic-style social engagement. Staff and participants will engage in conversation about a wide variety of topics that are culturally and personally relevant and interesting to participants. Each day, participants will be able to choose from topic options. Participants will also receive a phone call once per week that lasts approximately 10 minutes; interviewers ask brief questions to monitor participant social activities and health conditions.
Adebrelimab injection was started on Day 1 of each cycle, followed 30 minutes later by intravenous drip of Paclitaxel for Injection(Albumin Bound). Combined treatment for 6 to 8 weeks, after efficacy evaluation, the investigator decides the subsequent treatment regimen, or until disease progression, toxicity intolerance, initiation of new anti-tumor therapy, withdrawal of informed consent, or the investigator judges that the subject needs to withdraw from the study treatment. Following RECISTv1.1 defined progression (as assessed by the investigator), study drug may continue if the investigator assesses that the subject is still receiving clinical benefit and tolerates study treatment.
LAIR1, a receptor found on immune cells, is capable of binding to collagen and is involved in immune-related diseases. However, the precise contribution of LAIR1 expressed on hepatocellular carcinoma (HCC) cells to tumor microenvironment is still unclear. In our study, bioinformatics analysis and immunofluorescence were employed to study the correlation between LAIR1 levels and clinical indicators. Transwell and scratch tests were used to evaluate how LAIR1 affected the migration and invasion of HCC cells. The chemotactic capacity and alternative activation of macrophages were investigated using RT-qPCR, transwell, and immunofluorescence. To investigate the molecular mechanisms, transcriptome sequencing analysis, Western blot, nucleus/cytoplasm fractionation, ELISA, and cytokine microarray were employed. We revealed a significant correlation between the presence of LAIR1 and an unfavorable outcome in HCC. We indicated that LAIR1 promoted migration and invasion of HCC cells through the AKT-IKKβ-p65 axis. Additionally, the alternative activation and infiltration of tumor-associated macrophages induced by LAIR1 were reliant on the upregulation of IL6 and CCL5 within this axis, respectively. In conclusion, blocking LAIR1 was found to be an effective approach in combating the cancerous advancement of HCC.
PURPOSE:To obtain a readily usable vitamin compound having good stability, by adding vitamins to a solubilizing agent, dissolving the vitamins while heating, mixing the resultant solution with a solid base prepared from gelatin, agar flour and water, injecting the mixture into a rubber bag with an injection tool. CONSTITUTION:Vitamins A, D3 and E are added to a solubilizing agent, e.g. polyoxyethylene sorbitan ester of a fatty acid, castor oil derivative of polyoxyethylene and sucrose ester of a fatty acid and dissolved while heating, preferably at 85+ or -1 deg.C to give a transparent solution, which is then mixed with agar flour and water and heated to prepare a solid base. The resultant base is, as necessary, incorporated with molasses, skimmilk powder, soybean cake flour, aromatizing flavor to give a composition for improving the palatability of domestic animals. The dissolved solution of the vitamins is added to the solid base to prepare a compatibilized solution and the composition for improving the palatability is added to give a pasty form. The resultant pasty mixture is then injected into a rubber bag with an injection tool and hermetically sealed.
OBJECTIVE: To evaluate the effect of metformin on the survival of patients with diabetes mellitus complicated with renal cell carcinoma by Meta-analysis.
METHODS: To collect the required data, we looked through the databases of the Cochrane Library, PubMed, and EMBASE, as well as the network for querying registration data from clinical trials (https://clinicaltrials.gov). Retrieve relevant ongoing or closed clinical trials. To avoid publication bias, the search process is limited to randomized controlled trials, and the search results are not limited to language, publication time, or other restrictions. All included studies need to be evaluated according to the quality evaluation standard of the Cochran system evaluation manual. The relevant data were statistically analyzed by Revman 5.3 software. In the evaluation of overall survival (OS) and progression-free survival (PFS), the index of hazard risk (HR) was selected in this paper.
RESULTS: Eight cohort studies were included in the analysis. Partial and metastatic subgroup analysis of renal cell carcinoma demonstrated no significant effect of metformin on PFS, CSS, or OS. There was no evidence of publication bias, according to the findings.
CONCLUSION: This systematic review and meta-analysis found that metformin did not improve survival rates for diabetic patients with renal cell carcinoma.
The participants were informed about the research and the mean score was calculated by applying the Vaginal Breech Delivery Management Knowledge Test to the participants before the vaginal delivery management training of the breech-presented fetus was given within the scope of the Risky Delivery and Postpartum Period Course. After playing the mobile game, Vaginal Breech Birth Management Post-Knowledge Test and General Satisfaction Level Test were applied to the participants again. In addition, the Mobile Game Evaluation Form was applied to the participants in the game group and their opinions on the mobile educational game were determined. Test-retest reliability was calculated by applying the Vaginal Breech Delivery Management Knowledge Retention Test 14 days later.
To elucidate the genetic basis of complex diseases, it is crucial to discover the single-nucleotide polymorphisms (SNPs) contributing to disease susceptibility. This is particularly challenging for high-order SNP epistatic interactions (HEIs), which exhibit small individual effects but potentially large joint effects. These interactions are difficult to detect due to the vast search space, encompassing billions of possible combinations, and the computational complexity of evaluating them. This study proposes a novel explicit-encoding-based multitasking harmony search algorithm (MTHS-EE-DHEI) specifically designed to address this challenge. The algorithm operates in three stages. First, a harmony search algorithm is employed, utilizing four lightweight evaluation functions, such as Bayesian network and entropy, to efficiently explore potential SNP combinations related to disease status. Second, a G-test statistical method is applied to filter out insignificant SNP combinations. Finally, two machine learning-based methods, multifactor dimensionality reduction (MDR) as well as random forest (RF), are employed to validate the classification performance of the remaining significant SNP combinations. This research aims to demonstrate the effectiveness of MTHS-EE-DHEI in identifying HEIs compared to existing methods, potentially providing valuable insights into the genetic architecture of complex diseases. The performance of MTHS-EE-DHEI was evaluated on twenty simulated disease datasets and three real-world datasets encompassing age-related macular degeneration (AMD), rheumatoid arthritis (RA), and breast cancer (BC). The results demonstrably indicate that MTHS-EE-DHEI outperforms four state-of-the-art algorithms in terms of both detection power and computational efficiency. The source code is available at https://github.com/shouhengtuo/MTHS-EE-DHEI.git .
PURPOSE:The titled inhibitor, containing a modified glycyrrhetinic acid com pound as an active constituent without developing pseudoaldosteronism which is a side effect. CONSTITUTION:A carcinogenic promoter inhibitor containing a modified glycyrrhetinic acid compound expressed by formula I [X is residue of a compound expressed by formula II, III or IV; R1 and R2 are H or may be acylated by a monocarboxylic acid or dicarboxylic acid, and the free acid of the product is used directly in the case of the dicarboxylic acid of may be converted into an acid addition salt] as an active constituent. The does thereof is preferably 30-750mg/human/day for oral administration and about 60% above-mentioned amount for parenteral administration. The dosage form is powder, granule, tablet, sugar-coated table,t capsule, etc. as an oral agent, and a solvent, e.g. water, propylene glycol or polyethylene glycol, is used for an injection. Furthermore, 2% solution or ointment is used as an agent for external use.
[PROBLEMS]  To provide compounds usable in treating diseases in which a calcium sensing receptor (CaSR) participates, in particular, hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS]  It is found out that a novel piperidine derivative, which is characterized by being substituted by an amino methyl group substituted by an arylaklyl group, etc. at one of the 3- and 4-positions and by an aryl group, a heteroaryl group, etc. at the other, or its salt has an excellent CaSR-agonistic regulatory effect and a high selectivity from CYP2D6 that has a risk of drug interaction.  Owing to the above-described characteristics, these novel piperidine derivatives are useful as a remedy for diseases in which a CaSR participates (for example, hyperparathyroidism, renal osteodystrophy, hypercalcemia, etc.).
The utility model relates to a medicinal substrate which is convenient for storing, carryover and using in the medical care field, in particular to a substrate of a medicinal plaster which is used for pasting at the ill position of a patient. The utility model is that the surface of a pharmaceutical absorbed layer is contacted with a covering film and is provided with small pits which are uniformly distributed. The small pits can be rectangular pits, small triangular pits, small hexagon pits, or small circular pits. The longitudinal cross sections of the small pits are tapered. Each small pit is filled with the medicaments in the utility model. When the substrate of the medicinal plaster is transported or stored, wherever the medicinal plaster is arranged in any mode, the medicaments are all in each small pit, the medicaments are evenly distributed on the surface of the medicinal plaster, and the defect that the medicaments are congregated toward one edge of the medicinal plaster can not be generated.