anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The goal of this project is to better understand how interacting and working with plants in a group gardening activities program in a greenhouse, or a group art program that takes place indoors and is devoid of images or depictions of plants influences the overall health and well-being of participants.

A total anticipated study population (N = 40) will consist of up to 20 healthy women randomly assigned to the art activities group, and up to 20 healthy women assigned to the gardening group. There will be measurements of heart rate, systolic and diastolic blood pressure, and psychometric assessments including satisfaction of social activities at baseline and post intervention. Heart rate and blood pressure measurements will be taken at the beginning and end of each of the eight gardening or arts sessions. Psychometric assessments of study participants will be conducted at baseline and post-intervention. Each treatment group will be divided into two smaller groups of up to ten women each that will receive the gardening or art interventions on different days of the week. The participants in the gardening or art groups will receive an experimental intervention consisting of 8 gardening or art sessions, each approximately 60 minutes in duration over a four week treatment period. Gardening and art sessions will take place at the same time of day twice each week, and follow a standardized programming sequence to ensure equivalency of intervention across all sessions. Ambient environmental conditions in the greenhouse during the gardening sessions will be monitored and recorded. The gardening activities will emphasize growing plants from seeds, plant propagation techniques, transplanting, and plant-mediated taste, visual, olfactory and touch sensory stimulation. All gardening sessions will begin with a short educational module introducing the plants and gardening activities taking place during each session. Art activities will include papermaking, image transfer, visual storytelling, linocut printmaking, paper batik, mixed media collage, and sensation drawing, and begin with a short educational module of the activity.

In addition to the pre- and post-intervention assessments and measurement, psychometric assessments will be administered for depression symptomatology, mood states and perceived stress at specific points during the gardening and art activities to evaluate any changes over time resulting from the interventions. Participant heart rate and blood pressure measurements will be made at the beginning and at the end of all gardening and art sessions.
The invention discloses a formula of a medicine for treating rheumatism. An externally-applied medicine of the formula comprises rhizoma drynariae, morinda umbellate, achyranthes bidentata, vervain, sarcandra glabra, ardisia japonica and hydrocotyle vulgaris. The externally-applied medicine is prepared by putting the traditional Chinese herbal medicines into 300-500ml of white wine of which the concentration is greater than 50 degrees, sealing and soaking for no less than 30 days, thereby obtaining the externally-applied medicine. An oral medicine of the formula comprises angelica sinensis, codonopsis pilosula, ligusticum wallichii, vervain, solanum deflexicarpum, mulberry root, morinda umbellate and radix zanthoxyli. The oral medicine is prepared by adding 500g of water into the medicines, soaking for more than 20 minutes, boiling with strong fire, and boiling for more than 30 minutes with soft fire till 200-250g of decoction is left, wherein the decoction is taken orally, the medicine dregs are further boiled for 1-2 times by the same method, and the decoction is also taken orally. The prepared externally-applied medicine is adsorbed and coated at an affected part for 12-36 hours by using water-absorbing articles such as cotton, gauze and the like, the medicine is replaced every 12 hours, subsequently the affected part is wiped and cupped by using a cupping instrument, and at the same time, one dosage of the oral medicine is taken per day. The traditional Chinese herbal medicines with different components have different functions, the functions supplement one another, and thus the purposes of curing rheumatism, dredging the channels and removing hydrops are achieved.
PURPOSE: Although microsatellite stability/Epithelial-mesenchymal transition (MSS/EMT) subtypes have been reported in multiple cancer prognosis studies, strong confounding factors between MSS/EMT (usually with Lauren's diffuse phenotype) and diffuse gastric cancer (GC) may obscure the independent prognostic value of diffuse GC. Additionally, recent studies suggest a strong correlation between mural stratification based on CT and diffuse GC. This study aims to investigate potential prognostic factors of MSS diffuse GC using mural stratification and to develop a risk assessment model.
METHODS: This retrospective study included 131 patients with MSS diffuse GC who underwent radical surgery. Univariate and multivariate Cox proportional hazards regression analysis was used to identify model predictors and construct a nomogram for overall survival (OS) and recurrence-free survival (RFS) risks. The model's performance was evaluated using ROC, accuracy, and C-index. Internal validation of the model was conducted using the bootstrap resampling method.
RESULTS: Among 131 cases, 60 cases (45.8%) exhibited grade 2 mural stratification, which correlated with a poorer tumor prognosis and a more invasive phenotype. Furthermore, a nomogram for predicting OS and RFS prognosis was established based on multivariate results (age, extranodal invasion, mural stratification, and/or P53). The nomogram demonstrated excellent performance, with an AUC of 0.859 (95% CI 0.794-0.924) for OS and 0.859 (95% CI 0.789-0.929) for RFS. Internal validation using 1000 bootstrap samples yielded AUC values of 0.845 and 0.846 for OS and RFS, respectively.
CONCLUSION: Grade 2 mural stratification based on CT imaging revealed a more aggressive invasive phenotype, characterized by increased LN metastasis, higher rates of peritoneal metastasis, and a poorer short-term prognosis. Furthermore, the CT phenotype-based nomogram demonstrates favorable discrimination and calibration, enabling convenient individual short-term prognostic evaluation following resection of MSS diffuse GC.
1500847 Antibiotic BAYER AG 8 March 1976 [8 March 1975] 09180/76 Heading C2A A novel antibiotic is characterized in the following manner: (a) it is a neutral substance and does not migrate on electrophoresis; (b) it consists of carbon, hydrogen and oxygen; (c) it has a specific rotation of [α]20 D = -6À6 degrees in a solution which contains 1% by weight of antibiotic in methanol; (d) it exhibits a maximum at # = 307 nm. in the U.V. spectrum; (e) it is readily soluble in chloroform, acetone, ethyl acetate, acetonitrile, dimethyl formamide, dimethyl sulphoxide, methanol and ethanol and is sparingly soluble in water, diethyl ether, petroleum ether and cyclohexane; (f) it contains methoxy groups; and (g) it eliminates reducing sugars on hydrolysis with 10% strength by weight sulphuric acid at 80‹ C. The antibiotic is further characterized by the spectra indicated in Figs. 1-4 (not shown). The antibiotic may be prepared by culturing one or both Actinoplanes strains SE 73 (ATCC 31058) and SE 73/B (ATCC 31060) under aerobic conditions in a culture medium containing assimilable sources of carbon, nitrogen and mineral substances. The antibiotic may be incorporated into pharmaceutical and animal feed compositions.
Vascular cell overgrowth and lumen size reduction in pulmonary vein stenosis (PVS) can result in elevated PV pressure, pulmonary hypertension, cardiac failure, and death. Administration of chemotherapies such as rapamycin have shown promise by inhibiting the vascular cell proliferation; yet clinical success is limited due to complications such as restenosis and off-target effects. The lack of in vitro models to recapitulate the complex pathophysiology of PVS has hindered the identification of disease mechanisms and therapies. This study integrated 3D bioprinting, functional nanoparticles, and perfusion bioreactors to develop a novel in vitro model of PVS. Bioprinted bifurcated PV constructs are seeded with endothelial cells (ECs) and perfused, demonstrating the formation of a uniform and viable endothelium. Computational modeling identified the bifurcation point at high risk of EC overgrowth. Application of an external magnetic field enabled targeting of the rapamycin-loaded superparamagnetic iron oxide nanoparticles at the bifurcation site, leading to a significant reduction in EC proliferation with no adverse side effects. These results establish a 3D bioprinted in vitro model to study PV homeostasis and diseases, offering the potential for increased throughput, tunability, and patient specificity, to test new or more effective therapies for PVS and other vascular diseases.
BACKGROUND: Immature teeth with necrotic pulps present multiple challenges to clinicians. In such cases, regenerative endodontic procedures (REPs) may be a favorable strategy. Cells, biomaterial scaffolds, and signaling molecules are three key elements of REPs. Autologous human dental pulp cells (hDPCs) play an important role in pulp regeneration. In addition, autologous platelet concentrates (APCs) have recently been demonstrated as effective biomaterial scaffolds in regenerative dentistry, whereas the latest generation of APCs-concentrated growth factor (CGF), especially liquid phase CGF (LPCGF)-has rarely been reported in REPs.
CASE PRESENTATION: A 31-year-old woman presented to our clinic with the chief complaint of occlusion discomfort in the left mandibular posterior region for the past 5 years. Tooth #35 showed no pulp vitality and had a periodontal lesion, and radiographic examination revealed that the tooth exhibited extensive periapical radiolucency with an immature apex and thin dentin walls. REP was implemented via transplantation of autologous hDPCs with the aid of LPCGF. The periodontal lesion was managed with simultaneous periodontal surgery. After the treatment, the tooth was free of any clinical symptoms and showed positive results in thermal and electric pulp tests at 6- and 12-month follow-ups. At 12-month follow-up, radiographic evidence and three-dimensional models, which were reconstructed using Mimics software based on cone-beam computed tomography, synergistically confirmed bone augmentation and continued root development, indicating complete disappearance of the periapical radiolucency, slight lengthening of the root, evident thickening of the canal walls, and closure of the apex.
CONCLUSION: hDPCs combined with LPCGF represents an innovative and effective strategy for cell-based regenerative endodontics.
FIELD: medicine. SUBSTANCE: method involves selecting donor serum samples by applying immunoenzyme analysis and PCR (polymerizno-chain reaction) for detecting hepatitis B virus DNA and anti-HBS antibodies. Diluting solution is prepared on the base of selected sera. HBSAg standard is diluted with the diluting solution. Solution thermodegradation and stabilization test is carried out. EFFECT: improved vaccine quality control; constant virus protein concentration on reference palette within long time period. 5 cl, 1 dwg, 2 tbl
In France, more than 150 000 patients have been infected by the SARS-CoV-2 virus and COVID has been responsible for more than 100 000 hospitalizations. Following the acute phase of this disease, some patients may have sequelae, such as breathing difficulties or malnutrition. However, the prevalence and intensity of those sequelae still remain unknown. Thus, a functional and respiratory rehabilitation program associated with personalized nutritional care may be necessary to improve those patients' prognosis.

This study aims to evaluate the effectiveness of a 4-week rehabilitation program following the acute phase of COVID. This program includes regular physical activity supervised by a physical acticity educator, a systematic malnutrition screening and a nutritional follow-up performed by a dietitian. Patients will be randomized in two groups: rehabilitation program (intervention group) or usual care (control group). Quality of life, physical performance, respiratory capacities and nutritional status will be assessed in both groups at inclusion and one month later (corresponding to the end of the rehabilitation program for the intervention group).
PURPOSE:To obtain the title pad which keeps always the diseased part dry to promote the therapy by filling fiber bundles for tobacco filter with a porous mineral powder and applying them to the diseased part and fixing with a socks or the like. CONSTITUTION:Fiber bundles for tobacco filter such as cellulose acetate or viscose rayon are combined with 4 to 8wt.%, based on the fiber weight, of a plasticizer such as triacetylglycerol and mixed with a porous mineral powder of, preferably 40 to 80 mesh particle sizes. Then, the mixture is formed in the same way as in tobacco filter, resultant rods are cut into pieces of an appropriate length to give the therapeutic pad for foot tinea. The porous mineral powder is, for example, silica gel, zeolite, pumice or the like. The mineral powder is impregnated with an antifungal for external purposes to give a durative antifungal effect. When it is used, the pad is inserted between foot fingers or placed on the finger base and fixed by putting on one sock.
A method for detecting resonance breathing, according to one embodiment, includes receiving sensor data from at least one sensor on a wearable device, the sensor data including sensor data selected from the group consisting of heartrate data and breath data. The sensor data is processed to detect breathing resonance. A wearable device having sensor-dependent behavior modification, according to one embodiment, includes a housing configured for positioning on a human body. A plurality of sensors are positioned in and/or on the housing for detecting a condition and/or an environment of the wearable device. A processing circuit in the housing is coupled to the sensors for receiving sensor data therefrom. A computer readable storage medium is coupled to the processing circuit, the computer readable storage medium having program instructions stored therein for causing the processing circuit to change a state of the wearable device based on the sensor data.
In a patient with interstitial lung disease (ILD) of known or unknown etiology other than idiopathic pulmonary fibrosis (IPF), progressive pulmonary fibrosis (PPF) is defined by worsening lung fibrosis on high-resolution computed tomography (HRCT), decline in lung function, and/or deterioration in symptoms. The INBUILD trial involved 663 patients with PPF who were randomized to receive nintedanib or placebo. The median exposure to trial medication was approximately 19 months. The INBUILD trial provided valuable learnings about the course of PPF and the efficacy and safety of nintedanib. The relative effect of nintedanib on reducing the rate of forced vital capacity decline was consistent across subgroups based on ILD diagnosis, HRCT pattern, and disease severity at baseline, and between patients who were and were not taking glucocorticoids or disease-modifying anti-rheumatic drugs and/or glucocorticoids at baseline. The adverse events most frequently associated with nintedanib were gastrointestinal, particularly diarrhea, but nintedanib was discontinued in only a minority of cases. The results of the INBUILD trial highlight the importance of prompt detection and treatment of PPF and the utility of nintedanib as a treatment option.
The invention provides a polypeptide composition for promoting skin microcirculation and application thereof. The polypeptide composition consists of carnosine and palmitoyl pentapeptide-4. Wherein the mass ratio of the carnosine to the palmitoyl pentapeptide-4 is (1:4) - (4: 1). The effective dosage range of the polypeptide composition of the invention is 10 mug/mL to 2000 mug/mL. Compared with a cool skin feeling regulator, the polypeptide composition can increase the content of acetylcholine in skin or inhibit the activity of thrombin in skin capillaries, and really achieves the effect of promoting skin microcirculation. Compared with a natural extract, the polypeptide composition has definite components and no redundant impurities, avoids hidden skin allergens due to complex components of the natural extract or residual impurities such as solvents, heavy metals and the like introduced by an industrial extraction process, and greatly reduces the risk of toxic and side effects on a human body. Compared with natural extracts, the polypeptide composition has small addition amount in cosmetics or skin external medicine preparations, and can also achieve the effect of promoting skin microcirculation.
A vitamin D calcium tablet is disclosed. The tablet is prepared from 475-500 parts by weight of calcium carbonate, 0.0033-0.005 part by weight of vitamin D, 180-200 parts by weight of white granulated sugar, 90-100 parts by weight of glucose, 17-20 parts by weight of citric acid, 130-140 parts by weight of starch, 8-10 parts by weight of magnesium stearate and 100-200 parts by weight of a coating agent. The tablet is reasonable in formula. Vitamin D calcium is more easily absorbed than calcium of common preparation forms. A coating process is adopted, can separate oxygen and water and has a function of maintaining medicine properties of inner core tablets, an antiseptic function and a sterilizing function. A natural antiseptic is adopted. The tablet is free of essence and pigment. Healthcare functions of the tablet are increased.
Niemann-Pick Disease (NPD) is a rare autosomal recessive disease belonging to lysosomal storage disorders. Three types of NPD have been described: NPD type A, B, and C. NPD type A and B are caused by mutations in the gene SMPD1 coding for sphingomyelin phosphodiesterase 1, with a consequent lack of acid sphingomyelinase activity. These diseases have been thus classified as acid sphingomyelinase deficiencies (ASMDs). NPD type C is a neurologic disorder due to mutations in the genes NPC1 or NPC2, causing a defect of cholesterol trafficking and esterification. Although all three types of NPD can manifest with pulmonary involvement, lung disease occurs more frequently in NPD type B, typically with interstitial lung disease, recurrent pulmonary infections, and respiratory failure. In this sense, bronchoscopy with broncho-alveolar lavage or biopsy together with high-resolution computed tomography are fundamental diagnostic tools. Although several efforts have been made to find an effective therapy for NPD, to date, only limited therapeutic options are available. Enzyme replacement therapy with Olipudase α is the first and only approved disease-modifying therapy for patients with ASMD. A lung transplant and hematopoietic stem cell transplantation are also described for ASMD in the literature. The only approved disease-modifying therapy in NPD type C is miglustat, a substrate-reduction treatment. The aim of this review was to delineate a state of the art on the genetic basis and lung involvement in NPD, focusing on clinical manifestations, radiologic and histopathologic characteristics of the disease, and available therapeutic options, with a gaze on future therapeutic strategies.
BACKGROUND: Healthcare transition can be challenging for young people and families living with chronic kidney conditions, including those with rare renal disorders who often have multi-systemic conditions, those who have undergone kidney transplantation, and those who face intense treatments like dialysis. Comprehensive, holistic healthcare transition interventions are required, encompassing physical, psychosocial, sexual, educational and vocational support.
AIM: This manuscript presents a systematic scoping review synthesising the healthcare transition interventions to support youth and families within nephrology services.
METHODS: This review followed Arksey and O'Malley's five-stage framework, updated by Levac, Colquhoun and O'Brien and the Joanna Briggs Institute. Six databases were systematically searched: CINAHL Plus with Full Text, Embase, PsycINFO, Web of Science, PubMed, and the Applied Social Sciences Index and Abstracts (ASSIA), locating 12,662 records. Following a systematic screening process, 28 articles met the inclusion criteria. Results were analysed systematically and presented using the PAGER framework developed by Bradbury-Jones et al. (2022).
RESULTS: Various interventions were sourced. Three broad patterns emerged: 1. Contextual Factors, e.g. cultural differences between paediatric and adult services; 2. Major Intervention Components, e.g. parental/familial/peer-to-peer support, and 3. Personal factors, e.g., self-management ability.
CONCLUSION: Few interventions are available to support youth with rare renal disorders, specifically. Future research must be directed at this cohort. Healthcare transition timing remains hotly contested, with additional guidance required to support decision-making. Finally, limited interventions have been evaluated for practice.
IMPLICATIONS: This review has provided various considerations/recommendations that should be taken into account when designing, implementing or evaluating future healthcare transition supports.
FIELD: chemical-pharmaceutical industry, medicinal plants. SUBSTANCE: viburnum (Viburnum) waste processing extract from kernels and/or husks and/or oil cake contains complex of oligomeric procyanidines that is prepared by extraction of viburnum kernels and/or husks and/or oil cake with water or an aqueous-ethanol mixture with alcohol content 70 wt.-%, not above. Invention can be used in chemical, biological or chemical- pharmaceutical industry for preparing complex of oligomeric procyanidines eliciting high antiradical activity. Invention provides expanding assortment of vegetable extracts comprising complex of oligomeric procyanidines and eliciting the enhanced antiradical activity. EFFECT: improved preparing method, valuable biological properties of extract. 1 tbl
A method for designing and manufacturing a long release capsule for extended delivery of a drug to a patient in an ingestible capsule. The method includes determining a drug volume to be delivered and a drug delivery rate. A buoyancy element is selected based on the drug volume. A release port is selected based on the drug delivery rate and the properties of the drug. The design elements are used to produce a capsule design for an ingestible capsule. The design of the capsule is used to generate manufacturing instructions and produce the capsule.
Methods, computer systems, and computer-storage media for presenting third-party clinical information on a mobile device are provided. A request for clinical information is received from a user of the mobile device. After the user is authenticated, a number of plug-in applications are determined for the user. The request for clinical information is communicated to the plug-in applications. The clinical information is received from the plug-in applications in the form of one or more generic hierarchical structures populated with the clinical information. The populated hierarchical structures are rendered for display on the mobile device.