anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present disclosure provides adenine base editors (ABEs) that have context specificity, i.e., a preference for a pyrimidine positioned 5' of the target adenosine, or preference for a purine positioned 5' of the target adenosine. In addition, methods for targeted nucleic acid editing are provided. Further provided are pharmaceutical compositions comprising the ABEs. Also provided are vectors useful for the generation and delivery of the ABEs, including vector systems for engineering the ABEs through directed evolution. Cells containing such vectors and ABEs are also provided. Further provided are methods of treatment and uses comprising administering the ABEs.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to the dosed composition of prolonged release for 24 h and a single dosed form of this composition. Composition is made as capsule including spheroids containing venlafaxine hydrochloride, microcrystalline cellulose and hydroxypropylmethylcellulose. Invention relates to also film coating for particles containing ethylcellulose with 44.0-51.0% of ethoxy-groups and hydroxypropylmethylcellulose with 28.0-30.0% of methoxy-groups and 7.0-12% of hydroxypropoxy-groups. Composition provides the improved control of blood plasma drug levels as compared with usual tableted compositions being the latters must be intaken twice or more per a day. Proposed composition decreases amount of cases of nausea and vomiting as compared with usual tablets. EFFECT: enhanced effectiveness and improved properties of composition. 14 cl, 3 tbl, 4 ex
33 patients will be given a home exercise program that strengthens the waist and hip girdle (to be shown once in the hospital by a physiotherapist and the form of the exercises will be given), 33 patients will be given kinesiotaping (KT) with ligament correction technique with the exercise program, and 33 patients will be given kinesiotaping with lymphatic correction technique with the exercise program. Patients will do the exercises once a day for 1 month. KT will be repeated once a week for 3 weeks. When taping is performed, it will be kept for 5 days.The patients' pain at rest and during movement will be measured using the Visuel Analog Scale (VAS). Patient Global Assessment and Oswestry Disability Index (ODI) will be questioned. Evaluations will be performed before, 4th week and 1 month after treatment (8th week).
The present invention relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases, and a preparing method and the application thereof. The traditional Chinese medicine preparation of the present invention contains tea, tuckahoe, cornus officinalis, cassia seed, radix trichosanthis, scrophularia, mulberry leaf, gingko, double blossom, stir-frying hawthorn, endothelium corneae gigeriae galli, baical skullcap root, notoginseng and stir-frying Fructus Amomi Villosi. The concrete formula and the preparing method are disclosed in the instruction. The present invention has the advantages that the present invention carries on the essence of a secret prescription handed down in the family from generation to generation, and the focus of infection on human bodies is comprehensively regulated and treated at multitarget positions and multitarget points. The present invention also has the advantages of wide range of application, few toxic or side effects, good taste, convenient taking, safety, high efficiency and medium cost; all the ingredients are all-natural plants. The present invention is preferably adopted for health care by patients suffering from hypertension, hyperglycemia, hyperlipoidemia and complication thereof. The product of the present invention is mainly used for treating hypertension, hyperglycemia, hyperlipoidemia and complication thereof.
The invention belongs to the technical field of biological medicine, and discloses a toad-derived antibacterial peptide of black orbit, a preparation method and application thereof, wherein the antibacterial peptide comprises any one of WK3-NH  2 、WR3-NH 2 、IR3-NH 2 , and the amino acid sequences of the antibacterial peptide are respectively shown in SEQ ID NO: 1. SEQ ID NO: 2. SEQ ID NO: 3. The antibacterial peptide Cath-DM of the toad of the black orbit is obtained by structural modification: the core sequence of Cath-DM is intercepted, and the truncated sequence is replaced by amino acid Try/Ile-Arg/Lys for C-terminal amidation. The antibacterial peptide has short sequence, small molecular weight, low hemolytic property and broad-spectrum antibacterial activity, and the antibacterial activity of WR3-NH  2  is optimal. After the group of antibacterial peptides are subjected to serum action, the group of antibacterial peptides have high-efficiency inhibition effect on gram-negative bacteria, but do not damage gram-positive bacteria, and the group of the polypeptides have the potential of becoming a narrow-spectrum antibiotic substitute.
Those allocated to the AMIC treatment group will also receive microfracture. Once the walls of the debrided lesion are confirmed to be stable with a probe, the exact size of the defect will be measured for templating of the scaffold. The dry Chondro-Gide® matrix will be prepared by cutting it to 10% smaller than the focal defect (as it increases in size about 10% after moistening). Once the cartilage lesion is dried manually, the implant will then be secured to the defect in a press-fit fashion to the surrounding cartilage. Manual pressure is then applied to secure the implant into the defect and the hip is released from traction and rotated to facilitate further fixation of the graft. Traction is then applied to arthroscopically confirm position and fixation of the implant.
The invention relates to a Secalonic acid M derived from penicillium oxalicum and a preparation method thereof. The compound has effect in inhibiting human cancer cell proliferation. The structural formula is as follows: . Culturing Penicillium oxalicum ( Penicillium oxalicum ) IBPT-6, obtaining a fermentation product, and separating and purifying the compound from the fermentation product. Experiments prove that the compound has better anti-tumor activity on human cancer cells. Can be used for preparing human cancer cell proliferation inhibition drugs or antitumor drugs for research.
Active surveillance (AS) is the preferred option for patients presenting with low-intermediate-risk prostate cancer. MRI now plays a crucial role for baseline assessment and ongoing monitoring of AS. The Prostate Cancer Radiological Estimation of Change in Sequential Evaluation (PRECISE) recommendations aid radiological assessment of progression; however, current guidelines do not advise on MRI protocols nor on frequency. Biparametric (bp) imaging without contrast administration offers advantages such as reduced costs and increased throughput, with similar outcomes to multiparametric (mp) MRI shown in the biopsy naïve setting. In AS follow-up, the paradigm shifts from MRI lesion detection to assessment of progression, and patients have the further safety net of continuing clinical surveillance. As such, bpMRI may be appropriate in clinically stable patients on routine AS follow-up pathways; however, there is currently limited published evidence for this approach. It should be noted that mpMRI may be mandated in certain patients and potentially offers additional advantages, including improving image quality, new lesion detection, and staging accuracy. Recently developed AI solutions have enabled higher quality and faster scanning protocols, which may help mitigate against disadvantages of bpMRI. In this article, we explore the current role of MRI in AS and address the need for contrast-enhanced sequences. CLINICAL RELEVANCE STATEMENT: Active surveillance is the preferred plan for patients with lower-risk prostate cancer, and MRI plays a crucial role in patient selection and monitoring; however, current guidelines do not currently recommend how or when to perform MRI in follow-up. KEY POINTS: Noncontrast biparametric MRI has reduced costs and increased throughput and may be appropriate for monitoring stable patients. Multiparametric MRI may be mandated in certain patients, and contrast potentially offers additional advantages. AI solutions enable higher quality, faster scanning protocols, and could mitigate the disadvantages of biparametric imaging.
The invention discloses a Chinese herb teabag with fatigue relieving efficacy. The Chinese herb teabag is prepared from 26-35% of Astragalus membranaceus, 15-25% of Atractylodes japonica, 5-15% of Codonopsis pilosula, 5-15% of acanthopanax senticosus, 5-15% of Eucommia ulmoides, 5-15% of cinnamomum cassia, and 5-15% of glycyrrhiza uralensis. The invention also relates to a preparation method of the Chinese herb teabag with fatigue relieving efficacy. The method includes a steaming process, a drying process, a mixing crushing process and a tea bag packaging process. Compared with the Chinese medicinal decoction decocted by a traditional Chinese medicinal pot, the Chinese herb teabag has the characteristics of convenient carrying, simple taking and low cost. And after all the processes, the unpleasant taste of traditional Chinese medicines themselves can be removed while the pharmacological effect is maintained. The Chinese herb teabag not only has the taste similar to that of general tea products, but also can be widely used as a Chinese herbal tea for relieving fatigue and stress and enhancing immunity.
This is a four-way cross-over study. Subjects, healthy volunteers, will receive a single dose of GSK573719 (500ug), GW642444 (50ug), GSK573719 (500ug)+GW642444 (50ug) administered concurrently, or placebo at each of the four treatment periods. There is a minimum wash-out period of seven days between doses. On enrolment into the study, subjects will be assigned to one of four treatment sequences which are based on a Williams design in accordance with the randomization schedule generated by GSK prior to study start.
FIELD: medicine. ^ SUBSTANCE: invention relates to veterinary, in particular to development of complex medications for prevention and treatment of malfunctions of metabolic and immune processes in animals. Method of obtaining complex medication for prevention and treatment of malfunctions metabolic and immune system includes mixing of succinic acid, novocaine, immunostimulant, dissolving of obtained medication in distillated water and sterilising by autoclaving. As immunostimmulant applied is sodium nucleinate or derinate with the following component ratio, wt %: succinic acid 1.5; sodium nucleinate or derinate 2.0; novocaine 0.25; distillated water - the remaining part. ^ EFFECT: invention insures increasing of medication efficiency. ^ 4 tbl, 2 ex
Non-invasive forms of brain stimulation such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are currently being investigated as alternative or adjunctive therapies for pain. Clinical interest in these techniques continues to grow because of rising opiate abuse and inadequate pain management strategies. Despite this enthusiasm, studies on the efficacy of repetitive TMS (rTMS) for pain have produced mixed results. Some of the most promising and informative research has focused on rTMS for perioperative pain. In two different postoperative studies, a single session of left dorsolateral prefrontal cortex (DLPFC) rTMS after gastric bypass surgery reduced morphine self-administration by 40% when compared to sham stimulation. These data are particularly fascinating given the role of the DLPFC in top-down pain processing.

Centered at the juncture of Brodmann Areas (BAs) 9 and 46, the DLPFC remains a popular therapeutic target for rTMS given its accessible location and presumed role in high-order cognition and emotional valence. Animal and human studies suggest that cingulofrontal regions like DLPFC may modulate pain perception via recruitment of opioidergic midbrain and brainstem structures like the periaqueductal gray (PAG) and the rostroventromedial medulla (RVM), respectively. These data outline the functional circuitry that might be involved in the analgesic effects of DLPFC rTMS.

While many studies aim to evaluate the clinical efficacy of DLPFC rTMS for pain management, few have examined how it affects pain processing. Imaging the cerebral signature of pain before and after left DLPFC rTMS might reveal information about pain circuitry and help to elucidate the mechanism by which prefrontal rTMS may produce analgesia. Previous studies suggest that opioid blockade abolishes left but not right DLPFC rTMS-induced analgesia. In this study, our a priori hypothesis was that left DLPFC rTMS would attenuate blood oxygenation-level dependent (BOLD) signal response to painful stimuli in pain processing regions. More specifically, we anticipated that midbrain and medulla BOLD signal changes induced by left DLPFC rTMS would be abolished by pretreatment with the μ-opioid antagonist naloxone.
FIELD: veterinary mycology. SUBSTANCE: invention relates to new strain Microsporium canis showing high level of sporogenesis, population homogeneity, high virulent properties that provide the objective control of vaccine immunogenic activity against dermatophytosis in animals. Strain Microsporium canis is deposited in Microorganism Collection ВГНКИ veterinary preparations at N 20-LTG. For estimation of immunogenic properties of biopreparations the control strain Microsporium canis N 20-LTG provides more stable and reliable results and can be used as standard for epizootic strain virulence study. EFFECT: enhanced effectiveness of immunogenicity control. 1 tbl
Each patient will receive 1 mg/kg lidocaine followed by 2 mg/kg propofol IV once prior to continuous propofol infusion for MRI sedation at 200 mcg/kg/min. Dose will be increased by 50 mcg/kg/min up to 300 mcg/kg/min for movement and decreased to 150 mcg/kg/min if no movement after 30 minutes. Additional 1 mg/kg propofol bolus administered at time of each movement. Study to be terminated if movement persists despite above interventions.
OBJECTIVE: The purpose of this study is comparing the newborn hearing screening failure rate between phenylketonuria (PKU) infants and matched healthy control infants.
PATIENTS AND METHODS: Between April 2021 and April 2023, data obtained from the national newborn hearing screening program were examined for patients who presented to the pediatric metabolism clinic of Konya City Hospital with a clinical and genetic diagnosis of PKU. A healthy control group, matched for age and gender, was established. The newborn hearing screening test results, demographic information, and pregnancy data of infants with PKU and the control group were compared to assess risk factors.
RESULTS: In the initial screening test, 23 out of 73 PKU infants (31.5%) and 12 out of 73 infants in the control group (16.4%) failed the test (p = 0.033). Among the 23 PKU infants who did not pass the first test, 9 (35%) also failed the second test and were referred. In contrast, all 12 infants in the control group who did not pass the first test passed the second test. The failure rate in the second test was significantly higher in PKU infants compared to the control group (p = 0.003). It was observed that the maternal age of PKU infants who underwent the second test was significantly higher than that of the control group (p < 0.029). Diagnostic hearing test results were found to be normal in all nine PKU patients who failed the secondary screening test and were referred to a tertiary center.
CONCLUSION: In our study, it was determined that infants with phenylketonuria (PKU) who did not have any risk factors for hearing loss failed the hearing screening test significantly more than healthy infants.
Claudins (CLDNs) play a crucial role in regulating the permeability of epithelial barriers and can impact tumor behavior through alterations in their expression. However, the precise mechanisms underlying the involvement of CLDNs in breast cancer progression remain unclear. This study aimed to investigate the role of CLDN11 in breast cancer progression. Utilizing the TCGA database and clinical specimens from breast cancer patients, we observed reduced expression of CLDN11 in tumor tissues, which correlated with poor prognosis in breast cancer patients. In vitro, silencing of CLDN11 enhanced the proliferative and migratory characteristics of breast cancer cell lines MCF-7 and MDA-MB-231. Mechanistically, CLDN11 deficiency promoted the upregulation of Forkhead Box M1 (FOXM1) by activating the hedgehog signaling pathway, thereby sustaining tumor progression in breast cancer. In vivo, blockade of hedgehog signaling suppressed the tumor progression induced by CLDN11 silencing. Our study highlights the significance of the CLDN11/FOXM1 axis in breast cancer progression, suggesting CLDN11 as a potential diagnostic indicator and therapeutic target for clinical therapy.
OBJECTIVE: Patients with chronic intestinal failure use home parenteral nutrition infusion support. Non-compliance of home parenteral nutrition treatment is well documented, especially if clinical resources are remote. Objective delivery data from Infusion Pump reports have the potential to support treatment progress and planning. The aim of this study was to report the efficacy and accuracy of the Eitan Insights digital health platform for home parenteral nutrition use (a platform providing data-driven insights from the pump-recorded data).
METHODS: A prospective, single-center observational study of 20 patients treated with home parenteral nutrition ≥3 d/wk was conducted over 2022. The patients recorded the pre- and postinfusion home parenteral nutrition bag weight, duration of infusion, and alarms. We compared manual records to the pump data. Repeated measures analysis of variance was used for statistical analysis.
RESULTS: A total of 45 data sets were collected, with no adverse events noted. In multiple comparisons between patient factors and descriptive statistics, there was no significant difference between manually recorded and pump-recorded data for volume infused (mean values of manual versus pump were 1707 ± 362 mL and 1708 ± 405 mL; P = 0.939) and infusion duration (mean values of manual versus pump iwere 9h 43 min ± 2.48 SD versus 9h 45 min ± 2.41 SD; P = 0.858).
CONCLUSION: The data collected by the digital platform accurately reflect patients' infusion data. This connected device has the potential to allow clinicians to be more informed and assess treatment trends and proactive resource planning through the Infusion Pump data insights.
Caregivers will participate in three 45-minute sessions with the interventionist over the telephone or video-conferencing (per caregiver preference) approximately bi-weekly. These sessions take place while the patient and caregiver are completing the three follow-up dyadic sessions. Efforts will be made to schedule the caregiver support sessions during weeks that fall between dyadic coaching sessions to minimize intervention burden on caregivers (i.e., avoiding scheduling two sessions for the caregiver in the same week).
A composition and a method of producing a composition which simulates hydration, cleansing and other properties of native vernix. The composition contains hydratable water-in-oil emulsified particles providing water vapor transport and evaporative water loss properties, rheologic, tactile, cleansing, and other properties simulating native vernix. The inventive composition simulates hydrophobic properties of native vernix by a matrix of one or more lipids that are present in native vernix, in which the simulated cells are dispersed. In one embodiment, the lipids are substantially physiologic. Any or all the following lipids may be used, each of which is found in native vernix, and each of which is available commercially :  cholesterol esters, ceramides, triglycerides, cholesterol, free fatty acids, phospholipids, wax esters, squalene, wax diesters, and cholesterol sulfate.  Other physiologically acceptable lipids, such Petrolatum and/or mineral oil, may be included in some formulations.
BACKGROUND: Lower gastrointestinal tract stenosis is commonly diagnosed and is typically treated with surgery or endoscopic balloon dilation (EBD). Radial incision and cutting (RIC) is a novel treatment approach that has several benefits compared with EBD and surgery. Although RIC has demonstrated a high technical success rate and has been shown to improve subjective symptoms, previous studies revealed that restenosis after RIC remain unsolved. Herein, we report the design of a prospective, multicenter, single-arm, interventional, phase II trial to evaluate the safety of local triamcinolone acetonide (TA) administration and its feasibility in preventing restenosis after RIC for lower gastrointestinal tract stenosis.
METHODS: The major inclusion criteria are age 20-80 years and the presence of benign stenosis in the lower gastrointestinal tract accessible by colonoscope. We will perform RIC followed by local administration of TA to 20 participants. The primary outcome is the safety of local TA administration, which will be assessed by determining the frequency of adverse events of special interest. The secondary outcomes are the technical success rate of RIC, duration of procedure, improvement in subjective symptoms, and duration of hospitalization. The outcomes, improvement in subjective symptoms, and long-term results will be evaluated using descriptive statistics, Student's t-test, and Kaplan-Meier curve, respectively.
DISCUSSION: This explorative study will provide useful information regarding the safety of TA administration after RIC, which may contribute to further investigations.
For training data pairs comprising training text (a radiological report) and training images (radiological images associated with the radiological report), a first encoder network determines word embeddings for the training text. A concept is generated from the operation of layers of the first encoder network, which is regularized by a first loss between the generated concept and a labeled concept for the training text. A second encoder network determines features for the training image. A heatmap is generated from the operation of layers of the second encoder network, which is regularized by a second loss between the generated heatmap and a labeled heatmap for the training image. A categorical cross entropy loss is calculated between a diagnostic quality category (classified by an error encoder) and a labeled diagnostic quality category for the training data pair. A total loss function comprising the first, second, and categorical cross entropy losses is minimized.