anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention provides methods for inhibiting, i.e. reducing, neutralizing and/or antagonizing, at least one activity of Th 1 cells using cortistatin polynucleotides or polypeptides, or cortistatin analogues or variants, or pharmaceutical products of same. The present invention is also directed at new methods of diagnosis, prognosis, and monitoring the progression and treatment of disorders associated with Th 1 cells. The present invention is also directed at methods for selective detection and for evaluation of problem compounds for intervention (treatment) concerning and prevention of disorders associated with Th 1 cells. The present invention also provides new pharmaceutical products composed of Th 1-cell antagonists, e.g. cortistatin polynucleotides or polypeptides, or cortistatin analogues, or cortistatin variants, which specifically reduce, neutralize and/or antagonize at least one activity associated with Th 1 cells.
Antibiotics are commonly prescribed in dentistry as a prophylactic measure, particularly following tooth extraction which are overused and misused in dental practice, leading to a rise in antimicrobial resistance. By randomly assigning 152 dental patients aged between 18 to 50 years, this trial aims to evaluate the outcomes such as infection rates, healing times, pain and adverse effects of patients receiving antibiotics after tooth extraction versus those who do not. The study will be conducted at the Oral and Maxillofacial Surgery Department, Dental Unit, Chittagong Medical College.

Tooth extractions will be performed under aseptic conditions, followed by standard post-operative care. The intervention group will receive 625 mg amoxicillin with clavulanic acid three times daily for 7 days post-extraction, while the control group will not receive any antibiotic. Both groups will receive 400 mg ibuprofen and 20 mg omeprazole twice daily. Surgeons, patients and assessors will be blinded to group assignments, with a third party managing medication distribution. Clinical evaluations will occur on the 3rd, 7th, and 14th days post-extraction. The Landry wound healing index will be used to assess tissue healing and pain will be recorded using a visual analogue scale. Surgical Site Infection will be diagnosed based on specific clinical criteria. Any Adverse reactions will be monitored. Rescue Additional analgesia and antibiotics will be provided as needed.

Data analysis will be done using the χ²-test, t-tests and logistic regression, with a significance level of 5%. Ethical considerations include obtaining informed consent from all participants. An independent expert team will conduct safety monitoring to manage any adverse events. The results of this study could provide valuable insights for future clinical protocols in dental surgery and contribute to the broader public health goal of reducing unnecessary antibiotic use.
FP matched placebo pMDI one puff twice daily for two weeks then FP four puffs twice daily for two weeks. After a washout period of 2 weeks, they then received FP 250μg per actuation pMDI one puff twice daily (total daily dose 500μg) for two weeks then FP 250μg per actuation pMDI four puffs twice daily (total daily dose 2000μg) for two weeks.
Single intradermal dose of active NP2. An open label study extension will offer up to two additional doses of active NP2 between weeks 4-10 following the previous dose.
The invention provides means, methods, and compositions of matter useful for treatment of viral induced sexual dysfunction. In one embodiment the invention teaches the use of autologous bone marrow mononuclear cells as a source of endothelial repair in penile or clitoral tissues that has been damaged by viral causes. In one embodiment, said viral cause is COVID-19 infection. In some embodiments the invention discloses means of maintaining and/or increasing sexual function, in some cases the invention describes preservation of tissue mass and/or size by administration of regenerative cells. Said cells may be autologous, allogeneic or xenogeneic. In some embodiments the invention teaches the utilization of derivatives of regenerative cells such as exosomes and/or conditioned media.
Interjurisdictional migrations lead to seasonally changing patterns of exploitation risk, emphasizing the importance of spatially explicit approaches to fishery management. Understanding how risk changes along a migration route supports time-area based fishery management, but quantifying risk can be complicated when multiple fishing methods are geographically segregated and when bycatch species are considered. Further, habitat selection in dynamic environments can influence migration behavior, interacting with other management objectives such as water quality and habitat restoration. As a case study, we examined a novel acoustic telemetry data set for Lake Whitefish in Lake Erie, where they migrate through multiple spatial management units that are variably affected by seasonal hypoxia and host a variety of fisheries. Combining telemetry results with fishery catch and water quality monitoring, we demonstrate three exploitation risk scenarios: (i) high risk due to high residency and high catch, (ii) high risk due to high residency in time-areas with moderate catch, and (iii) low risk due to residency in time-areas with low catch. Interestingly, occupation of low risk refugia was increased by the development of hypoxia in adjacent areas. Consequently, fishery management goals to sustainably manage other target species may be directly and indirectly linked to water quality management goals through Lake Whitefish.
The present invention is oryzanol liposome with high absorption, high bioavailability and high stability and its preparation. The oryzanol liposome or oryzanol liposome precursor is prepared with oryzanol and phosphatide, cholesterol, supporting agent and other supplementary material. It has phosphatide/medicine weight ratio of 0.1-40, and is prepared through ethanol injecting process, film dispersion process, inverse evaporation process, extruding process or mechanical process. The supporting agent may be sorbitol, mannitol, cane sugar, etc. and has ratio to phosphatide of 0.01-400. The oryzanol liposome can act selectively on the autonomic nerve system of interbran and the center of endocrine system to improve autonomic nerve system, endocrine system and psychonerve. It is suitable for treating neurosis, climacteric syndrome, etc., and may be used in the assisting treatment of vascular headache and cerebral concussion sequelae.
In addition to usual care physiotherapy patients in the intensified physiotherapy group will receive an extra physiotherapy session of up to 30 minutes on every weekday starting on the first postoperative day. The session will include progressive functional training of basic mobility and walking in the ward delivered by an experienced physiotherapist affiliated with the trial. The aim of this additional session is to improve the functional advances achieved during the earlier physiotherapy session.
The invention discloses a litopenaeus vannamei L-type lectin, and a coding gene and application thereof. The L-type lectin gene lecV of the litopenaeus vannamei is cloned from the gill tissue of the litopenaeus vannamei for the first time, and the nucleotide sequence of the L-type lectin gene lecV is shown as 18 th to 1007 th bases of SEQ ID NO. 1. The amino acid sequence of the L-type litopenaeus vannamei lectin LecV is shown in SEQ ID NO. 2. The L-type litopenaeus vannamei lectin LecV has the functions of agglutinating bacteria and quickly removing the bacteria in bodies of the litopenaeus vannamei, so that the L-type litopenaeus vannamei lectin LecV participates in a prawn immune regulation and control mechanism, the research on the prawn immune regulation and control mechanism is promoted, a reliable genetic marker is provided for breeding prawn varieties with disease resistance and stress resistance properties, and a new target site can be provided for the genetic improvement of the litopenaeus vannamei.
550,345. Denture cleansing compositions. BEER, W. Aug. 8, 1941, Nos. 10114/41 and 10500/ 42. [Class 91] A denture cleansing composition comprises a mixture of finely powdered bath brick and whiting in equal proportions by weight. The amount of bath brick may be increased or decreased by 2 per cent. The compositions may be in paste form by the addition of just sufficient water to form a thick paste. A usable paste may be prepared from the latter by the addition of a preservative consisting of 1 part by volume of glycerine and 2 parts by volume of water. The usable paste may be prepared directly by the addition of a suitable quantity of the preservative to the powder composition. Half the amount of bath brick in the powder or paste compositions may be replaced by an equivalent amount of pumice powder.
OBJECTIVES: Cesarean scar pregnancy (CSP) is a rare dangerous condition with still no consensus on standard treatment. Suction curettage has been used as the first-line treatment for CSP with controversial outcomes. This study evaluates efficacy of ultrasound-guided suction curettage (UGSC) followed by cervical-isthmic placement of silicon semirigid three-way foley catheter.
MATERIALS AND METHODS: This study included 24 women with CSP. Preoperative ultrasound study was conducted. UGSC followed by placement of catheter was performed in all patients. The success rate and incidence of major complication, surgical time and hospital stay were recorded.
RESULTS: The success rate of UGSC followed by placement of foley catheter was 100 %, effectively reduced major complications and none of the patients had a blood loss higher than 900 ml. Median hospital stay was 2 days and median foley stay was 1 day. Surgery had limited last with a median of 17 min.
CONCLUSION: UGSC followed by foley placement is a safe effective treatment for CSP with a clinical resolution of 100 %. The catheter is easy to place under ultrasound guidance and prevents bleeding, reducing major procedures to solve the bleeding. Suction curettage in CSP treatment should be performed under ultrasound guidance and followed by cervical-isthmic placement of foley balloon.
A micromechanical pumping system is formed on a substrate surface. The pumping system uses a pumping element which pumps a fluid through valves which move in a plane substantially parallel to the substrate surface. An electromagnetic actuating mechanism may also be fabricated on the surface of the substrate. Magnetic flux produced by a coil around a permeable core may be coupled to a permeable member affixed to a pumping element. The permeable member and pumping element may be configured to move in a plane parallel to the substrate. The electromagnetic actuating mechanism gives the pumping system a large throw and substantial force, such that the fluid pumped by the pumping system may be pumped through a transdermal cannula to deliver a therapeutic substance to the tissue underlying the skin of a patient.
To explore the association and impact between viral myocarditis and mortality in patients with severe fever with thrombocytopenia syndrome. A dynamic analysis was conducted between fatal group and nonfatal group regarding the daily epidemiology data, clinical symptoms, and electrocardiogram (ECG), echocardiogram, and laboratory findings. Outcomes of patients with and without viral myocarditis were compared. The association between viral myocarditis and mortality was analyzed. Among 183 severe fever with thrombocytopenia syndrome patients, 32 were in the fatal group and 151 in the nonfatal group; there were 26 (81.25%) with viral myocarditis in the fatal group, 66 (43.70%) with viral myocarditis in the nonfatal group (p < 0.001), 79.35% of patients had abnormal ECG results. The abnormal rate of ECG in the fatal group was 100%, and in the nonfatal group was 74.83%. Univariate analysis found that the number of risk factors gradually increased on Day 7 of the disease course and reached the peak on Day 10. Combined with the dynamic analysis of the disease course, alanine aminotransferase, aspartate aminotransferase, creatine kinase, creatine kinase fraction, lactate dehydrogenase, hydroxybutyrate dehydrogenase, neutrophil count, serum creatinine, Na, Ca, carbon dioxide combining power, amylase, lipase, activated partial thromboplastin time and thrombin time had statistically significant impact on prognosis. The incidence of fever with thrombocytopenia syndrome combined with viral myocarditis is high, especially in the fatal group of patients. Viral myocarditis is closely related to prognosis and is an early risk factor. The time point for changes in myocarditis is Day 7 of the course of the disease.
Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs) have been suspected to play a role in the promotion of chronic inflammation, but the extent to which fecal miRNAs are interacting with the intestinal ecosystem in a way that contribute to diseases, including IBD, remains unknown. Here, fecal let-7b and miR-21 were found elevated, associated with inflammation, and correlating with multiple bacteria in IBD patients and IL-10-/- mice, model of spontaneous colitis. Using an in vitro microbiota modeling system, we revealed that these two miRNAs can directly modify the composition and function of complex human microbiota, increasing their proinflammatory potential. In vivo investigations revealed that luminal increase of let-7b drastically alters the intestinal microbiota and enhances macrophages' associated proinflammatory cytokines (TNF, IL-6, and IL-1β). Such proinflammatory effects are resilient and dependent on the bacterial presence. Moreover, we identified that besides impairing the intestinal barrier function, miR-21 increases myeloperoxidase and antimicrobial peptides secretion, causing intestinal dysbiosis. More importantly, in vivo inhibition of let-7b and miR-21 with anti-miRNAs significantly improved the intestinal mucosal barrier function and promoted a healthier host-microbiota interaction in the intestinal lining, which altogether conferred protection against colitis. In summary, we provide evidence of the functional significance of fecal miRNAs in host-microbiota communication, highlighting their therapeutic potential in intestinal inflammation and dysbiosis-related conditions, such as IBD.
With the deepening of the concept of tumor management, it is necessary to monitor the patient's gene during the course of treatment, especially in patients with acquired resistance of the first generation EGFR-TKI. Re-biopsy can effectively provide tissue samples as a "gold standard" for gene detection samples. While, the plasma circulating tumor DNA (ctDNA) detection is an important sample of gene detection and the treatment when tissue samples cannot be assessed. However, due to tumor heterogeneity and ctDNA detection technique sensitivity, plasma ctDNA and tissue samples of the test results are inconsistent. Therefore, the difference between re-biopsy tissue samples and plasma ctDNA samples will provide strong evidence for the application of plasma ctDNA in TKI-resistant patients.

The study was designed as a prospective and single center study. Fifty patients will be enrolled into the study and the clinical data of patients, including smoke history, cancer history, location, pathology, gene mutation status and so on of the first biopsy samples will be collected and recorded in a case report form. For patients recruited in the study, lesions which were assessed as progressive disease(PD) will be obtained by interventional pulmonology technology. And about 20ml peripheral blood will be collected at the same time. The tissue will be divided into two parts, one part was sent to Pathology Department of Shanghai Chest Hospital and will be processed with paraffin-embedded, and for those diagnosed NSCLC, the other part will be extracted with DNA and performed NGS for the qualified DNA sample and using Cobas to detect the T790M mutation. The matched peripheral blood will also be extracted with DNA and performed NGS and ddPCR.
A system and method for navigating an image series, the image series containing a number of substantially aligned planar images. First, the images of the image the image series are grouped into a number of subseries, the number of subseries being less than the number of substantially aligned planar images in the image series. A representative image series is generated by generating an image from each subseries. The representative image series is displayed. It is determined whether an image from the representative image series has been selected. If an image from the representative image series has been selected, then the subseries associated with the selected image is displayed.
The invention discloses a Chinese medicine composition for treating primary hypertension. The primary hypertension belongs to categories, such as dizziness and headache in the traditional Chinese medicine. The dizziness has a close relation with liver and kidney. Clinically, a yin deficiency and yang excess type is one of common primary hypertension syndromes of traditional Chinese medicine. The Chinese medicine composition disclosed by the invention is prepared into pills from the following traditional Chinese medicines: selfheal, chrysanthemum, semen cassiae, butterflybush flower, apocynum venetum, coix seeds, motherwort, caulis spatholobi, Chinese yam and eucommia bark and adding an appropriate amount of honey. Clinical tests in our institute prove that the Chinese medicine composition has the total effective rate of 95.8 percent and is free of side effects, low in treatment cost and worthy of being clinically popularized and applied.
The invention relates to a BCS IV drug prodrug, preparation and application thereof, in particular to a BCS IV drug prodrug containing a targeting intestinal MCT1 carrier protein, a pharmaceutical composition containing the prodrug and a preparation method thereof. The nanoparticle can obviously improve the solubility and the pharmacy of BCS IV drugs based on a 'solubilization-permeation promotion' tandem strategy of a nanocrystallization and intestinal transporter targeting prodrug, and is used for oral administration. Belongs to the technical field of medicine. The invention provides a compound shown as a general formula (I), a geometric isomer and pharmaceutically acceptable salts, hydrates and solvates thereof: wherein X and Drug are as described in the claims and specification. The invention designs an oral prodrug taking MCT1 as a carrier based on the characteristic that an intestinal MCT1 transporter is expressed in a whole intestinal segment, so as to improve intestinal cell uptake and transport of a drug with poor membrane permeability. The pharmaceutical composition taking the high molecular material as the stabilizer has high in-vitro dissolution rate, and can further solve the problem of oral absorption of the insoluble prodrug.
Tai Chi Exercises + Cycling exercises. Treatment session of 60 min will be given 3 times a week for 6 weeks.
A method employing pattern recognition techniques for identifying the functional status of patients with chronic disease is described. This method describes a process by which sets of cardiopulmonary exercise gas exchange variables are measured during rest, exercise and recovery and stored as unique data sets. The data sets are then analyzed by a series of feature extraction steps, yielding a multi-parametric index (MPI) which reflects the current functional status of a patient. The method also employs a description scheme that provides a graphical image that juxtaposes the measured value of MPI to a reference classification system. An additional description scheme provides a trend plot of MPI values measured on a patient over time to provide feedback to the physician on the efficacy of therapy provided to the patient. The method will enable physicians to gather, view, and track complicated data using well-understood visualization techniques to better understand the consequences of their therapeutic actions.
Hyperproliferation of vascular smooth muscle cells (VSMCs) is a driver of hypertensive vascular remodeling. This study aimed to uncover the mechanism of BTB and CNC homology 1 (BACH1) and microRNAs (miRNAs) in VSMC growth and hypertensive vascular remodeling. With the help of TargetScan, miRWalk, miRDB, and miRTarBase online database, we identified that BACH1 might be targeted by miR-196a-5p, and overexpressed in VSMCs and aortic tissues from spontaneously hypertensive rats (SHRs). Gain- and loss-of-function experiments demonstrated that miR-196a-5p suppressed VSMC proliferation, oxidative stress and hypertensive vascular remodeling. Double luciferase reporter gene assay and functional verification showed that miR-196a-5p cracked down the transcription and translation of BACH1 in both Wistar Kyoto rats (WKYs) and SHRs. Silencing BACH1 mimicked the actions of miR-196a-5p overexpression on attenuating the proliferation and oxidative damage of VSMCs derived from SHRs. Importantly, miR-196a-5p overexpression and BACH1 knockdown cooperatively inhibited VSMC proliferation and oxidative stress in SHRs. Furthermore, miR-196a-5p, if knocked down in SHRs, aggravated hypertension, upregulated BACH1 and promoted VSMC proliferation, all contributing to vascular remodeling. Taken together, targeting miR-196a-5p to downregulate BACH1 may be a promising strategy for retarding VSMC proliferation and hypertensive vascular remodeling.
PURPOSE: The purpose of this study was to inform the revision of a targeted surveillance risk registry by identifying which risk factors predict postnatally identified hearing loss (PNIHL) in children who pass newborn hearing screening and to determine whether hearing surveillance beyond the age of 1 year is warranted.
METHOD: We used retrospective analysis of the audiological outcomes of children born in the state of Queensland, Australia, between January 1, 2010, and December 31, 2019, who passed the newborn hearing screen with risk factors.
RESULTS: Approximately one third of children were lost to follow-up and could not be included in the analysis. Risk factors that predicted PNIHL in the analyzed cohort were as follows: syndromes associated with hearing loss, craniofacial anomalies, perinatal infections, and family history of permanent childhood hearing loss. Severe asphyxia did not predict PNIHL but yielded some cases of significant bilateral hearing loss. Hearing loss in children with a history of prolonged ventilation was mild and/or unilateral in nature (except in cases where the hearing loss was due to an unrelated etiology). There were no cases of PNIHL in children with hyperbilirubinemia or neonatal bacterial meningitis. For the risk factors that predicted PNIHL, nearly all hearing losses were detected by 1 year of age, except for children with family history where one quarter of hearing losses had a later onset.
CONCLUSIONS: The four risk factors recommended for efficient postnatal identification of hearing loss are as follows: syndromes associated with hearing loss, craniofacial anomalies, perinatal infection, and family history of permanent childhood hearing loss. Hearing surveillance through to 1 year old is sufficient except for children with a family history, where a second phase assessment is indicated. Alternative targeted surveillance protocols and models of care are required to minimize loss to follow-up.