anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Individuals with chronic neuropathic pain who are na�ve to SCS and were selected for SCS trial period as part of their clinical care will participate in two study visits: before the beginning of the SCS trial and the end of the trial period. Data collection will be consistent across all data collection timepoints (T1 - T3) and include rs-fNIRS/EEG and clinical pain measures.
Provided are a ceria nanoparticle structure and a method for forming the same. The ceria nanoparticle structure includes a ceria nanoparticle cluster formed by gathering a plurality of ceria nanoparticles. The ceria nanoparticle structure can further include a water dispersible compound bonded to the ceria nanoparticle cluster. The method for forming the nanoparticle structure comprises a step of forming a ceria nanoparticle cluster with a plurality of ceria nanoparticles. The method for forming the nanoparticle structure can further comprise a step of coupling the water dispersible compound to the ceria nanoparticle cluster. The ceria nanoparticle structure according to embodiments of the present invention can effectively remove active oxygen species in the human body.
Participants who are randomly assigned to the treatment condition will receive the same standard care as those in the control condition and they will also receive access to the web-based CBT intervention. Participants in this condition will be asked to complete 24 CBT sessions, 2 sessions/topics per week for 12 weeks. Participants will be asked to complete the 18 "core modules" of the program during the first 9 weeks of the trial and then to re-visit important modules and complete optional modules of their choice during the final 3 weeks of the trial.
As with all therapeutic proteins, there is a potential for immunogenicity. The detection of antibody formation is highly dependent on sensitivity and specificity of the assay. Additionally, the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by several factors, including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. For these reasons, comparison of the incidence of antibodies to fremanezumab-vfrm in the studies described below with the incidence of antibodies in other studies to other products may be misleading. Clinical immunogenicity of AJOVY was monitored by analyzing anti-drug antibodies (ADA) and neutralizing antibodies in drug-treated patients. The data reflect the percentage of patients whose test results were positive for antibodies to AJOVY in specific assays.

In 3-month placebo-controlled studies, treatment-emergent ADA responses were observed in 6 out of 1701 (0.4%) AJOVY-treated patients. One of the 6 patients developed anti-AJOVY neutralizing antibodies at Day 84. In the ongoing long-term open-label study, ADA were detected in 1.6% of patients (30 out of 1888). Out of 30 ADA-positive patients, 17 had a neutralizing activity in their post-dose samples. Although these data do not demonstrate an impact of anti-fremanezumab-vfrm antibody development on the efficacy or safety of AJOVY in these patients, the available data are too limited to make definitive conclusions.
PURPOSE:To provide an antiviral agent containing raw soybean or albumen as an active component and capable of remarkably suppressing the proliferation of viruses such as rotavirus. CONSTITUTION:Raw soybean or albumen is used as an antiviral agent. Raw soybean is e.g. soybean grain, its powder, defatted raw soybean, deoiled raw soybean product such as raw soya milk, etc. Any egg composition such as liquid egg, frozen whole egg, etc., can be used as the albumen provided that the composition contains raw albumen. It is administered at a dose of 0.04-4g/kg daily for defatted raw soybean, 0.02-2g/kg daily for raw soya milk in terms of powder and 0.03-3g/kg daily for albumen in terms of powder. The proliferation of virus can be remarkably suppressed by the addition of >=0.2% antiviral agent of the present invention.
BACKGROUND: Non-communicable diseases (NCDs) are the leading cause of death around the world. The Dietary Quality Index-International (DQI-I) is one of the indicators that shows changes in diet and its association with NCDs. The aim of this study is to measure the association between the DQI-I and major metabolic risk factors.
METHODS: This study is a cross-sectional study based on data collected in the first phase of the prospective cohort study on Ravansar non-communicable diseases (RaNCD). To perform clinical and biochemical tests such as lipid profile, blood glucose and liver enzymes, blood samples were collected using standard vacutainer blood collection techniques. Information from the food frequency questionnaire containing 118 food items was used to score each person's DQI-I. Binary logistic regression was used to determine the association between the DQI-I tertile and the metabolic risk factors. Linear regression was also used for the association between subgroups of DQI-I score and the metabolic risk factors.
RESULTS: The total number of subjects in this study was 7,115, with a mean age of 47.14 ± 8.29 years. Dietary quality was generally poor, with 37.03% in the lowest tertile. Men had better dietary quality than women. Anthropometric measures, blood pressure, triglycerides and blood glucose were lower in the lowest tertile of dietary quality. A one-unit increase in the total DQI-I resulted in a 0.19 decrease in total cholesterol. Higher dietary quality was associated with a 22% increased risk of high triglycerides, a 19% increased risk of low high-density density lipoprotein, a 5% decreased risk of elevated low-density lipoprotein, a 42% increased risk of high blood pressure, and a 99% increased risk of high fasting blood glucose. Higher dietary quality was also associated with a 33% increased risk of overweight/obesity.
CONCLUSION: The study found that participants had poor dietary quality, with some favorable metabolic outcomes in the lowest tertile, but concerning associations in the highest tertile, including increased risk for high triglycerides, blood pressure, and obesity. The complex associations suggest that balanced, multifaceted interventions are needed.
A method and system for sharing intermediate medical image processing results among several different applications is disclosed. An application server serves as mediator between a medical image database storage, image processing applications, and a workstation display resident on a computer network. The application server polices the intermediate processing results from several different image processing applications in order for the image processing applications to share their intermediate results. By sharing the intermediate results, the application server helps to eliminate duplicate processing and inconsistent results between the image processing applications. The final image processing results are either stored on the medical image database or displayed on the workstation as needed. The image processing applications could reside on the application server or on their own separate networked computer. Alternatively, some image processing applications could reside on the application server and some on separate networked computers.
The control group (Group 3) will receive SHE. To ensure uniformity of the therapy model, the participants will also need to attend one half-day face-to-face session, covering topics related to sleep hygiene only. The capacity is also 30 participants.
Dysfunction of the masseter muscle may cause pathological kinking of the parotid duct leading to parotitis; MR sialography is a non-invasive radiological examination that allows to evaluate dynamically the ductal system of the parotid glands. In the present study we aimed to assess the relationships between Stensen's duct and masseter muscle and their implications in the aetiopathogenesis of recurrent parotitis secondary to masseter muscle dysfunction. Forty-one patients with recurrent unilateral parotitis and nine with bilateral recurrent parotitis, all with a clinical suspicious of masseter muscle hypertrophy due to bruxism were enrolled. They underwent ultrasonography as a first line examination and then MR sialography and sialendoscopy. Different anatomical features were studied. Involved parotid glands had a wider duct compared to contralateral unaffected parotid glands of patients with recurrent parotitis (p = 0.00134); male subjects with parotitis had a longer duct compared to the salivary glands of healthy patients (p = 0.00943 for affected glands and p = 0.00629 for the contralateral). A concordance between the evidence of an acute duct angle during sialendoscopy and a wider duct in patients with parotitis was observed although not statistically significant. These initial findings suggest that the masticatory muscle dysfunction related to bruxism seems to condition alteration of parotid duct course and anatomy thus favouring the occurrence of recurrent parotitis. A specific diagnostic iter based on clinical evaluation, dynamic ultrasonography and MR sialography, is therefore, mandatory to confirm the relationship between masseter muscle anatomy and parotid duct anomalies; this is the premise for an adequate therapeutic approach to underlying masticatory muscle disorder.
Exercises started to progress from static to dynamic positions in which muscle activation incorporate into functional tasks including trunk and extremity movements. Local, global muscle stability training, global muscle mobility training and strengthening training of these core structure was carried out progressively advancing more difficult. Patients received 20 sessions for one hour at clinic for ten-week treatment period.
Sickle cell disease is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Hemoglobin S polymerization leads to red cell rigidity, microvascular obstruction, inflammation, and end-organ ischemic injury. Our published data indicate that up to 50% of sickle cell patients have endothelial dysfunction due to impaired bioavailability of endogenous nitric oxide. Our studies indicate that this is due in large part to scavenging of nitric oxide by cell-free hemoglobin, with additional nitric oxide inactivation by superoxide. This suggests that therapies directed at restoring NO bioavailability might be beneficial. In patients with atherosclerotic vascular disease, the statin family of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase inhibitors significantly reduce stroke and myocardial infarction and restore endothelial-dependent relaxation of conducting arteries. Furthermore, statin therapy has now been clearly shown to reduce C-reactive protein levels and clinical events in patients with coronary artery disease independent of the effects on lipoproteins. The ability of statins to correct vascular inflammation and endothelial dysfunction makes this class of agents attractive to attempt to reverse these features of sickle cell pathobiology. This trial will aim to 1) establish the effects of oral atorvastatin treatment on endothelial-dependent relaxation in patients with sickle cell disease and endothelial dysfunction; 2) establish the effect of therapy on peripheral blood markers of inflammation and vascular function, and peripheral blood proteome and transcriptome profiles; and 3) investigate whether superoxide produced through xanthine oxidase limits nitric oxide bioavailability in patients with sickle cell disease.

In order to control for the possibility that advancing age, gender and ethnicity may influence vascular reactivity, we will also enroll age and gender-matched African-American controls in the baseline forearm blood flow portion of this study.
The currently proposed study addresses a critical need in the clinical care of school-aged children with TBI through the modification of an existing, proven efficacious treatment protocol for learning and memory deficits in persons with moderate to severe TBI, the modified Story Memory Technique (mSMT), as well as the conduct of a pilot double blind, placebo-controlled, RCT of this new pediatric adaptation of the mSMT. Over a decade of research and development conducted at our center has demonstrated the mSMT to be effective for improving new learning and memory in adults with TBI, across three realms of functioning: objective behavior, brain functioning and everyday life. This convincing data provides Class I evidence supporting the efficacy of the mSMT for improving new learning and memory in adults with TBI. Clinical applications around the world have equally attested to its utility in the clinical care of adults with TBI. This highlights the tremendous potential of the mSMT to vastly improve the everyday lives and educational successes of children and adoles-cents living with TBI and the resultant learning and memory deficits. The currently proposed pilot work will begin to document that efficacy. The results of this study therefore have the potential to change clinical practice, inform policy, and improve the lives of children and adolescents living with TBI.
In extremely premature infants who are ventilated there is ongoing lung injury \& lung inflammation. This can perpetuate the need for ongoing ventilation and these infants spend much longer in the hospital. The likelihood of chronic lung disease in this susceptible group is very high and they would need oxygen at home. Surfactant instillation has reduced the need for prolonged mechanical ventilation and to an extent the incidence of chronic lung disease (CLD). But many infants develop CLD and need prolonged oxygen treatment, diuretics and inhaled steroids to suppress the inflammation and obstruction of the airways. Some of the severely affected infants need orally administered steroids. The Inestigators propose to provide a dose of steroids instilled along with the surfactant in the very first day of life so as to prevent the vicious and ongoing cascade of lung injury and inflammation. As it is a poorly absorbed steroid and as only one or two doses is proposed to be used there is no effects within the body and it works locally within the lung. This is hoped to reduce CLD and improve long term outcomes. The population most susceptible to CLD is the extreme preterm infant with RDS who needs mechanical ventilation soon after birth. One of the groups will receive the surfactant with saline and the other group will receive the surfactant along with topical steroid. The groups will be followed during the hospital stay. survival along with duration of ventilation, duration of hospital stay and oxygen needs are noted. To study the hoped for long term benefits the investigators would note the long term neuro-development - if they were followed as per hospital policy between 18 months and 26 months. Intra-tracheal instillation of budesonide using surfactant as vehicle would facilitate its delivery to the periphery of the lung and would inhibit lung inflammation.
FIELD: biology, biochemistry. SUBSTANCE: method of epigenetic regulation of protein biosynthesis involves regulating action of protein synthesis by transposition of quantum oscillation time sequences to sound associated with protein elongation. This action can stimulate or inhibit protein biosynthesis depending on vibration frequency use at phase or antiphase with respect to elongation process. Obtained result can be confirmed by action of color transpositions of the group quantum oscillations arising from the space protein configuration during elongation process. Method ensures to detect metabolic role of proteins using their amino acid sequence and can be used in agriculture and medicine. EFFECT: improved method of protein biosynthesis regulation.
PURPOSE:To obtain a release controlling material capable of regulating a released amount depending upon change in various environmental conditions, especially change in circumferential temperature, containing a composition comprising a block copolymer of polyoxyethylene and polyoxypropylene, water and an acting substance in the interior. CONSTITUTION:A release controlling material containing a composition comprising a copolymer of polyoxyethylene and polyoxypropylene obtained by adding ethylene oxide to propylene glycol as a hydrophobic group, water and an acting substance (e.g. blood sugar lowering agent, hypotensor, cardiac or fertilizer, growth promoter and fungicide for agriculture, forestry and fisheries) as essential components in the interior. The material is applicable as a preparation of implant type in human and animal subcutaneous tissue or blood vessel. 100pts.wt. water is blended with 5-200pts.wt., preferably 10-50pts.wt. copolymer and <=100pts.wt., preferably <=10pts.wt. acting substance.
Blue light enhances the susceptibility of Nicotiana benthamiana to Phytophthora infestans, a causative agent of late blight disease. Investigating how blue light affects potato late blight resistance is an interesting aspect of exploring new ways to control late blight disease. Blue light photoreceptor phototropins (phot1, phot2) and their downstream interact protein StNRL1 have been shown to negatively regulate late blight resistance. In order to investigate whether other potato NPH3/RPT2-Like (NRL) family members are involved in regulating late blight resistance, this study focused on the potato NRL proteins containing RxSxS motif at the C-terminus. Another potato NRL protein StNRL-9, containing RxSxS motifs, was found to negatively regulate P. infestans resistance in potato and N. benthamiana. Overexpression of StNRL-9 in potato and N. benthamiana suppresses the accumulation of reactive oxygen species (ROS) and expression of the PTI marker genes NbWRKY7 and NbWRKY8. Similar to StNRL1, StNRL-9 interacts with the blue light receptors Stphot1 and Stphot2 on the cell membrane and could promote the degradation of a positive immune regulator StSWAP70. However StNRL-9 does not inhibit INF1-mediated cell death (ICD), which is different from the StNRL1 that inhibits ICD, indicating that both StNRL1 and StNRL-9 inhibit plant immunity in diverse ways. This study provides valuable information for further exploration of how plant phototropins and NRL family proteins regulate plant immunity.
Breast cancer (BC) is the most common cancer in women, with 2.3 million diagnoses in 2020. There is growing evidence that lifestyle factors, including dietary factors, particularly the complex interactions and synergies between different foods and nutrients (and not a single nutrient or food), may be associated with a higher risk of BC. The aim of this work was to evaluate how the Italian Mediterranean Index (IMI), the Greek Mediterranean Index, the DASH score, and the EAT-Lancet score can help lower the risk of BC, and analyze if chronic low-grade inflammation may be one of the possible mechanisms through which dietary patterns influence breast cancer risk. We evaluated the effect of adherence to these four dietary quality indices in the 9144 women of the ORDET cohort who completed a dietary questionnaire. The effect of adherence to dietary patterns on chronic inflammation biomarkers was evaluated on a subsample of 552 participants. Hazard ratios (HRs) with 95% confidence intervals (CIs) for BC risk in relation to the index score categories used were estimated using multivariable Cox models adjusted for potential confounders. Regression coefficients (β), with 95% CI for C-reactive protein (CRP), TNF-α, IL-6, leptin, and adiponectin levels in relation to adherence to dietary patterns were evaluated with the linear regression model adjusted for potential confounders. IMI was inversely associated with BC in all women (HR: 0.76, 95% CI: 0.60-0.97, P trend = 0.04), particularly among postmenopausal women (HR: 0.64, 95% CI: 0.42-0.98, P trend = 0.11). None of the other dietary patterns was associated with BC risk. Higher IMI and Greek Mediterranean Index scores were inversely associated with circulating CRP (β: -0.10, 95% CI: -0.18, -0.02, and β: -0.13, 95% CI: -0.21, -0.04). The higher score of the EAT-Lancet Index was instead associated with a higher concentration of circulating levels of CRP (β: 0.10, 95% CI: 0.02, 0.18). In conclusion, these results suggest that adherence to a typical Italian Mediterranean diet protects against BC development, especially among postmenopausal women, possibly through modulation of chronic low-grade inflammation.
A novel body with antibacterial effect is used as a medical or surgical aid and takes the form of a flexible plastic tube (8), with an antibacterial coating. The tube has a slit along its entire length. Preferably, the tube is polyvinyl chloride, coated with an antibacterial silver layer over its entire surface. The tube covers an orthopaedic fixture, especially an orthopaedic rod or screw (5). The tube (8) may surround another item (10), especially a drainage tube. Its internal diameter matches the external diameter of the object covered. A ring (12) may be pushed onto the tube and/or orthopaedic fixture, to secure it.
Craniofacial reconstructive surgery involves a surgical approach to the craniofacial region to repair cranial vault and facial deformities. These procedures are undertaken in young children to improve appearance, prevent functional disturbances, and enhance psychosocial development. The surgery is extensive, often requiring wide scalp dissections and multiple osteotomies and has been associated with significant morbidity. Reported complications include intra-operative cardiac arrest, massive blood loss, intraoperative tracheal extubation, venous air embolism, hypotension, coagulopathy, bradycardia, postoperative seizures, surgical site infections, facial swelling, and unplanned postoperative mechanical ventilation. The most severe and commonly seen problems are associated with the rate and extent of blood loss. Studies report estimated blood loss to average between 60% and 100% of the patient's estimated blood volume, with a range of 20-500%.(Hildebrandt et al 2007) The accurate and timely estimation of blood loss is very difficult and results in imprecise quantitative and qualitative replacement. Clinically important hypotension, metabolic acidosis, anemia, polycythemia, dilutional coagulopathy, cardiac arrest, and death are all related to blood loss. The creation of this prospective observational registry will provide a means to describe the incidence of these and other clinically important perioperative problems.
PURPOSE: Provided is a method for producing new protein Rv3369 containing 145 amino acids by using a microorganism transformed with an expression vector containing the gene encoding the new protein Rv3369. The Rv3369 has excellent sensitivity and specificity to tuberculosis patients and thus can be widely used for the diagnosis of tuberculosis. CONSTITUTION: New protein Rv3369 (sequence number 1) detected in Myco-bacterium tuberculosis contains 145 amino acids. A gene Rv3369 (sequence number 2) contains 435bp sequences and encodes the new protein. An Escherichia coli expression vector pRSETrv3369 contains the gene Rv3369. The Rv3369 is obtained by culturing transformed E. coli (pRSET/BL21)(Escherichia coli 3369 (pRSET/BL21))(KCCM10462). A diagnostic kit for the detection of M. tuberculosis infection contains an Rv3369-absorbed plate, a detector for detection of a reaction, a substrate liquid for detector, positive control serum, negative control serum, dilute and washing solutions for specimens.