anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths. Single oral amlodipine maleate doses equivalent to 4 or more mg amlodipine/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension.  
  
Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of amlodipine is limited. Reports of intentional overdosage include a patient who ingested 250 mg and was asymptomatic and was not hospitalized; another (120 mg) was hospitalized, underwent gastric lavage and remained normotensive; the third (105 mg) was hospitalized and had hypotension (90/50 mmHg) which normalized following plasma expansion. A case of accidental drug overdose has been documented in a 19-month-old male who ingested 30 mg amlodipine (about 2 mg/kg). During the emergency room presentation, vital signs were stable with no evidence of hypotension, but a heart rate of 180 bpm. Ipecac was administered 3.5 hours after ingestion and on subsequent observation (overnight) no sequelae were noted.  
  
If massive overdose should occur, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are essential. Should hypotension occur, cardiovascular support including elevation of the extremities and the judicious administration of fluids should be initiated. If hypotension remains unresponsive to these conservative measures, administration of vasopressors (such as phenylephrine) should be considered with attention to circulating volume and urine output.  
  
Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. As amlodipine is highly protein bound, hemodialysis is not likely to be of benefit.
Polyurethane quaternary ammonium salts are obtained by heating a solution of a polyurethane resin characterized by having present in the polymer backbone hydroxyl groups and at least one substituent selected from the group consisting of carboxylate radicals and carboxyl radicals dissolved in a water-miscible organic solvent for the resin at a temperature above 64 DEG  C. and below the decomposition temperature of said polyurethane resin with an organic chloride for a period of time; adding a strong base to the reaction mixture and continuing to heat said mixture to form a polyurethane quaternary ammonium hydroxide in solution; and precipitating the polyurethane quaternary ammonium hydroxide by pouring the reaction mixture into an excess of water. The polyurethane quaternary ammonium hydroxide so obtained may be dissolved in a solvent containing sufficient hydrochloric acid to bring the pH of the solution to 8; and the corresponding polyurethane quaternary ammonium chloride may be recovered from solution by evaporation of the solvent at a temperature below the decomposition point of the polyurethane quaternary ammonium chloride. A polyurethane quaternary ammonium sulfate may be prepared by dissolving in sulfuric acid a polyurethane resin characterized by having present in the polymer backbone hydroxyl groups and lactone groups to form a solution. This solution is added to an excess of water with stirring and neutralized with sodium hydroxide to bring the pH of the diluted solution to between 3 and 4. Evaporation of the solvent gives a residue containing a polyurethane quaternary ammonium sulfate and sodium sulfate. The polyurethane quaternary ammonium sulfate may be separated from the mixture by extraction with methanol.
Participants who have not lost weight or have lost less than or equal to 5% of their body weight, they will be given the option to crossover to the TRE arm. Following the initial 12-week period and end of study MRI, participants would restart another identical 12-week cycle but adhering to the exact steps of the TRE arm including another 4 visits with the registered dieticians (RDs) and an end of study visit with repeat Fibroscan, InBody 770 body composition scan, and MRI-PDFF.
FIELD: deformation of individual's keratin fibers, in particular, hairs. SUBSTANCE: method involves providing mechanical tightening of fibers and treating with gas and water steam. Prior to mechanical tightening, fibers are covered with composition containing at least one polysaccharide and/or one derivative of polysaccharide. Gas treatment is conducted for about 2 min at temperature at least equal to 75 C with following cooling and releasing fibers from mechanical tightening. Treating gas has temperature at least equal to 85 C, in particular within the range of 85-150 C. EFFECT: increased efficiency and improved quality of hairs. 12 cl
BACKGROUND: The failure of conventional therapies and the propensity for recurrence and metastasis make triple-negative breast cancer (TNBC) a formidable challenge with grim prognoses and diminished survival rates. Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor (CAR)-T cell therapy, presents innovative and potentially more effective strategies for addressing TNBC. Within this context, the inducible costimulator (ICOS), a member of the CTLA4/CD28 family, plays a crucial role in regulating immune responses and T-cell differentiation by binding to its ligand ICOSL. However, the impact of the ICOS/ICOSL axis on cancer varies.
METHODS: In this study, immunohistochemistry was conducted to examine the expression level of ICOSL in TNBC tumor tissues. We developed ICOS-enhanced B7H3-CAR-T cells (ICOS-B7H3-CAR) using the third-generation CAR-T cell technology, which featured magnified ICOS expression and targeted the B7H3 antigen. Xenograft and metastasis models of TNBC were conducted to examine the cytotoxicity and durability of CAR-T cells in tumors. Overexpression and CRISPR/Cas9-mediated knockout (KO) techniques were employed to regulate the expression of ICOSL on TNBC cell lines.
RESULTS: Notably, we observed elevated ICOSL expression in TNBC tumor tissues, which correlated with poor survival prognosis in patients with TNBC. Compared with conventional B7H3-CAR-T cells, ICOS-B7H3-CAR-T cells significantly inhibited the tumor growth of TNBC cells both in vitro and in vivo, accompanied by increased secretion of cytokines such as interferon gamma and tumor necrosis factor alpha. Furthermore, the in vivo experiments illustrated that ICOS-B7H3-CAR-T cells exhibited prolonged antitumor activity and could effectively eradicate metastases in a TNBC metastasis model, consequently extending survival. Importantly, manipulating the expression of ICOSL on TNBC cells through overexpression or KO significantly influenced the function of ICOS-B7H3-CAR-T cells. This suggests that the level of ICOSL expression on TNBC cells is critical for enhancing the potent antitumor effects of ICOS-B7H3-CAR-T cells.
CONCLUSION: Overall, our study highlights the potential clinical application of ICOS as a promising strategy for combating TNBC recurrence and metastasis.
The present invention addresses the problem of saving labor or decreasing personnel working reception at a facility that provides a product or service, without causing a customer to operate a portable information terminal. An order management unit 101 generates patient order data at a medical facility and performs management for each patient. An issuance control unit 102 controls outputting of an order card for indicating order data presented to a patient. A position management unit 103 manages patient position information for indicating the position, in the medical facility, of a patient possessing an order card. An examination management unit 104 manages an electronic medical record. A procedure management unit 105 manages procedure progress information indicating the status of progress of a post-examination procedure, the procedure progress information including the settlement of the amount of a fee determined on the basis of information including at least the electronic medical record. A monitoring unit 106 monitors whether the status of movement of the patient and the status of the procedure agree, on the basis of the order data, the patient position information, the electronic medical record, and the procedure progress information.
The invention provides a medicine for treating tuberculosis and a preparation method of the medicine. The medicine for treating tuberculosis is prepared by decocting country chickens eggs, beeswax and sesame oil, wherein each 500g of beeswax corresponds to 14-18 country chickens eggs and 500-1500g of sesame oil. The invention further provides a preparation method of the medicine for treating tuberculosis. The method comprises the following steps: a, shelling raw country chickens eggs, taking egg white and egg yolk, mixing with beeswax and sesame oil, and then decocting in a marmite to prepare a solid; and b, grinding the solid into powder, namely the medicine. The medicine for treating tuberculosis is good in curative effect, low in cost, simple to take, and suitable for various tuberculosis. According to the preparation method of the medicine for treating tuberculosis, the raw materials are easily available; the operation is simple and convenient; and the cost is low.
SLT treatment in the full circumference of the trabecular meshwork (360 degrees) consisting of 100+/-10 adjacent laser effects. The energy is adjusted to achieve the formation of micro bubbles at 50-75% of laser effects.
PURPOSE:To obtain a tissue-type plasminogen activation factor derivative having long half-life in blood and high fibrin-dissolution activity and containing a specific amino acid sequence by culturing a transformant having a specific DNA sequence. CONSTITUTION:A manifestation vector having a DNA sequence coding a specific tissue-type plasminogen activation factor (abbreviated as TPA) derivative is constructed. The TPA derivative has a structure of TPA provided that the amino acids from the 37th to the 41st counted from the N-terminal are substituted with hydrophobic amino acids such as valine and amino acids at specific positions such as 161st, 162nd and 165th (or 115th) are also substituted. The manifestation vector is introduced into a cultured animal cell such as CHO-K1 strain used as a host cell and the cell is cultured. The cultured product is recovered and purified to obtain the objective TPA derivative. Since the TPA derivative has improved durability in blood and keeps the thrombolytic activity comparable to natural TPA, it can be effectively used for the remedy of thrombosis.
Thumb carpometacarpal (CMC) osteoarthritis is painful and debilitating. Here, we explore outcomes of a modular, press-fit thumb CMC hemiarthroplasty prosthesis (BioPro). This surgical option permits minimal bone resection, sparing the trapezium, hence allowing revision options if necessary. A retrospective review of all cases of the modular thumb CMC implants performed at one community US center between 2018 and 2021 were included and invited for email or telephone review. Electronic records were examined for demographics, patient outcomes, and morbidity. Eleven patients underwent 11 thumb CMC joint hemiarthroplasties, mean age was 64.8 years (SD: 7.68 y), with 6 females. Six received surgery on their dominant extremity. Two were manual workers (both in the medical field), 6 office-based, 2 retired, and 1 homemaker. The preoperative median pain score (Visual Analog Score) was 8/10 (range: 5 to 10), reducing to 1/10 (range: 1 to 10) ( P =0.000033) with a median follow-up of 23 months (range: 13 to 39 mo). In all, 8/11 patients reported they would recommend this surgery to friends and family and opt for the same surgery on their contralateral hand if necessary. One patient reported persistent pain a year postoperatively. On review, the head of the implant was placed too deep into the trapezium. Another center found that this patient had a postoperative trapezium fracture and underwent revision with implant removal and conversion to a suspension arthroplasty. At 12 months, 10/11 thumb CMC hemiarthroplasty showed good pain relief, function, and patient satisfaction. The BioPro has a low risk of subluxation and allows salvage options to remain available should failure occur.
Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck with high incidence rate in South China, Southeast Asia and North Africa. The intervention of tumor-associated macrophages (Mφs) (TAMs)-mediated immunosuppression is a potential therapeutic strategy against tumor metastasis, but the exact mechanisms of TAM-mediated immunosuppression in nasopharyngeal carcinoma are unclear. Furthermore, how TAM affects the occurrence and development of nasopharyngeal carcinoma through metabolism is rarely involved. In this work, we revealed that NPC cells promoted M2-type Mφ polarization and elevated itaconic acid (ITA) release. Also, TAMs facilitated NPC cell proliferation, migration, and invasion through immune response gene 1 (IRG1)-catalyzed ITA production. Then, IRG1-mediated ITA production in TAMs repressed the killing of CD8+ T cells, induced M2-type polarization of TAMs, and reduced the phagocytosis of TAMs. Moreover, we demonstrated ITA played a tumor immunosuppressive role by binding and dampening ten-eleven translocation-2 (TET2) expression. Finally, we proved that ITA promotes NPC growth by facilitating immune escape in CD34+ hematopoietic stem cell humanized mice. In Conclusion, TAM-derived ITA facilitated NPC progression by enhancing immune escape through targeting TET2, highlighting that interfering with the metabolic pathway of ITA may be a potential strategy for NPC treatment.
A topical composition treating dandruff and seborrheic dermatitis of a scalp, by restoring architectonics to the scalp, eliminating fungal infection from the scalp, regulating metabolism of the scalp, regulating production and release of sebum from the scalp, and detoxifying the scalp. The topical composition includes an anti-fungal and scalp metabolism regulator, a delivery system, a detoxifying and impurity eliminator, and a fragrance. The anti-fungal and scalp metabolism regulator includes zinc pyrithione, climbazole, melatonin, multi-functional polyethylene glycol, and hydroxypropyl-ß-cyclodextrin. The delivery system includes first and second solutions. The first solution includes dimethylsulfoxide and hydroxypropyl-ß-cyclodextrin. The second solution includes distilled water, sodium chloride, potassium chloride, calcium chloride, sodium bicarbonate, imidazolidinyl urea, and multi-functional polyethylene glycol. The detoxifying and impurity eliminator includes preservatives, a pathogenic microorganism and exo- and endotoxins eliminator, and multi-functional polyethylene glycol. The preservatives include sodium benzoate and potassium sorbate. The pathogenic microorganism and exo- and endotoxins eliminator includes white activated charcoal powder.
The present invention discloses a kind of Folium hydrangeae strigosae treating laryngopharynx swelling and pain, belongs to the technical field of Chinese herbal medicine processing.Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz., Herba Dendrobii, Selenitum, the Radix Angelicae Dahuricae, Herba Rabdosiae glaucocalycis, Mannosum Kaki and EM original solution etc. is used to be prepared from.Principal agent Herba Dendrobii promotes the production of body fluid stomach reinforcing, replenishing YIN and removing heat, and tonifying five ZANG-organs asthenia is won thin, reinforcing YIN-essence, benefit essence.Radix Angelicae Dahuricae expelling wind and removing dampness, sensible pain relieving, the Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. compatibility that detumescence and apocenosis and clearing heat, detoxicating, dispelling dampness are subsided a swelling constitutes the medicine of core treatment laryngopharynx swelling and pain, and medicine interpromoting relation in five elements is helped each other and played good therapeutical effect.Herba Dendrobii and Selenitum nourishing YIN and clearing away heat are suitable for the pharyngolaryngitis for the treatment of overabundance of YANG leading to deficiency of YIN, Herba Rabdosiae glaucocalycis clearing away heat-damp and promoting diuresis blood circulation promoting and blood stasis dispelling, and the Radix Angelicae Dahuricae is warm in nature, are good at wind dispelling pain relieving, Yin Yang balancing, and all thing compatibilities reach to cure purpose with share strengthening vital QI to eliminate pathogenic factors.
BACKGROUND: Snail family zinc finger 1 (SNAI1) has been implicated in cancer progression and prognosis across various malignancies. This study aims to elucidate the prognostic significance of SNAI1 expression in Lung Squamous Cell Carcinoma (LUSC) using data from The Cancer Genome Atlas (TCGA) database.
METHODS: SNAI1 expression levels in LUSC patients were stratified using X-tile software to establish optimal cut-off values. Kaplan-Meier survival analysis was performed to assess the impact of SNAI1 expression on overall survival (OS). Univariate and multivariate Cox regression analyses were conducted to evaluate the prognostic value of SNAI1, considering clinical parameters such as age, clinical stage, and TNM classification. Additionally, we explored the interaction between SNAI1 expression and metastatic status, and performed Gene Set Enrichment Analysis (GSEA) to investigate associated cellular pathways. Correlations between SNAI1 and immune checkpoint molecules were also examined.
RESULTS: Kaplan-Meier analysis revealed significant differences in OS among high, medium, and low SNAI1 expression groups (p < 0.001), with median survival times of 1.6, 3.0, and 5.8 years, respectively. Dichotomizing patients into high and low SNAI1 expression groups confirmed that high SNAI1 expression was associated with significantly poorer OS (p < 0.001). SNAI1 remained an independent prognostic factor in multivariate analysis. High SNAI1 expression correlated with poorer survival outcomes regardless of metastatic status, and the combination of high SNAI1 expression and metastasis resulted in the poorest survival. GSEA identified significant associations between SNAI1 and inflammatory, immune response pathways. Positive correlations were observed between SNAI1 and key immune checkpoint molecules, suggesting an interplay with immune checkpoint mechanisms.
CONCLUSIONS: High SNAI1 expression is a robust prognostic indicator of poor survival in LUSC, independent of other clinical factors. Its association with immune checkpoint molecules highlights its potential as a therapeutic target. These findings underscore the prognostic and therapeutic relevance of SNAI1 in LUSC and possibly other cancers. Further research is warranted to explore targeted therapies against SNAI1.
An antifungal drug composition, and a drug delivery system for delivery of an antifungal drug composition, are described. The composition comprises Amphotericin B in an antifungally effective concentration, e.g. 0.1 - 10mg/L, in a pharmaceutically acceptable carrier and a Na?+, K+, 2Cl-¿ cotransport inhibitor, e.g. Bumetanide, in a concentration reducing or abolishing the cytotoxic effects of Amphotericin B, in a pharmaceutically acceptable carrier. The concentration of Bumetanide is e.g. 0.1 - 100 νmol/L. A method of delivering Amphotericin B to a mammal, including a human, in need of antifungal treatment, and a method of reducing or abolishing the cytotoxic effects of Amphotericin B on eukaryotic cells are also disclosed.
Several independent evaluations have supported the effectiveness of the Secret Agent Society (SAS) Program in improving the social-emotional functioning of children with Autism Spectrum Disorders (ASD) in clinic, school and remote Skype/telephone-assisted delivery contexts. Results from a pilot University clinic evaluation of the program for children with social-emotional difficulties but without ASD has also yielded positive findings, showing comparable treatment effects to those achieved for children with ASD in terms of improved social-emotional functioning. Within the USA, results from a two-year Buffalo School District implementation project and delivery of the program through USC University Center for Excellence in Developmental Disabilities (UCEDD Children's Hospital Los Angeles) have provided further support for the effectiveness and cross-cultural appropriateness of the intervention with children who have a range of mental health challenges. The present study aims to extend on the above literature by conducting a 6-month randomized controlled trial evaluating the effectiveness, utility and acceptability (including cultural acceptability) of the Secret Agent Society (SAS) social-emotional skills training program. Specifically, the study aims to evaluate the effectiveness of the SAS Program for 8-12 year-old children with social difficulties in the context of a range of diagnosed mental health conditions and/or developmental disorders, including anxiety disorders, ADHD, and Autism Spectrum Disorder. Outcome variables will include measures of child social functioning and mental health outcomes related to their primary diagnoses (e.g. anxiety, disruptive behaviour, etc).
This will be a single-center, prospective, randomized study conducted in King Khalid University Hospital. Patients diagnosed with either Alopecia universalis, Alopecia totalis or Ophiasic alopecia will be included in the study. Patients with contraindications such as diabetes mellitus, peptic ulcer, hypertension, infection, psychosis, heart or kidney disease, endocrine disorders (apart from a subclinical hypothyroidism and autoimmune thyroiditis) will be excluded. Children less than 5 years of age and those who received systemic or topical treatment within the last 4 weeks before enrollment will be also excluded. Those of child bearing potential had to have a negative urine pregnancy test result at baseline visit and should practice a reliable method of contraception throughout the study. 42 eligible patients will be randomly assigned to one of 3 treatment groups. Enrolled patients must provide written informed consent. Institutional review board approval will be obtained.