anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the peripheral nervous system, spontaneous activity in sensory neurons is considered to be one of the 2 main drivers of chronic pain states, alongside neuronal sensitization. Despite this, the precise nature and timing of this spontaneous activity in neuropathic pain is not well-established. Here, we have performed a systematic search and data extraction of existing electrophysiological literature to shed light on which fibre types have been shown to maintain spontaneous activity and over what time frame. We examined both in vivo recordings of preclinical models of neuropathic pain, as well as microneurography recordings in humans. Our analyses reveal that there is broad agreement on the presence of spontaneous activity in neuropathic pain conditions, even months after injury or years after onset of neuropathic symptoms in humans. However, because of the highly specialised nature of the electrophysiological methods used to measure spontaneous activity, there is also a high degree of variability and uncertainty around these results. Specifically, there are very few directly controlled experiments, with less directly comparable data between human and animals. Given that spontaneous peripheral neuron activity is considered to be a key mechanistic feature of chronic pain conditions, it may be beneficial to conduct further experiments in this space.
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include dipeptides of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position and L=Leu, Val, Ala or a non-polar amino acid. R is preferably aryl or heteroaryl, eventually substituted with halogens, amino and nitro groups. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.
FIELD: chemistry.SUBSTANCE: invention relates to chemical material science and can be used in making chemical sensors, electrochemical current sources, catalyst supports, chemical reagents, labels, chromatographic phases or dose of drug in microcapsules. Arrays of carbon vertically oriented nanotubes are synthesized from hydrocarbon with ferrocene on high-defect surface of silicon at temperature from 600–1,000 °C. To form high-defect surface monocrystalline silicon is treated with abrasive paste with subsequent etching with hydrofluoric acid. Coaxial regular carbon nano-mesostructures formed from chaotically interlaced carbon nanotubes forming a stable spatial shape with a configuration based on the topology of the hollow annular cylinder with an outer diameter of 1–60 mcm at a ratio of the length to the outer diameter of 10 to 10. Obtained carbon nano-mesostructures are milled, sieved and classified by size. Ends of the obtained microcapsules are opened by subjecting them to oxidation by thermochemical or electrochemical treatment. For thermochemical treatment, atomic or molecular oxygen or ozone is used. For electrochemical treatment electrolysis is carried out in solution of alkali, acid or ammonium chloride.EFFECT: invention enables to obtain carbon nano-mesostructures of stable size and shape reproducible as a result of synthesis, as well as expand field of use by filling cavities of microcapsules with various substances and excipients.15 cl, 20 dwg, 15 ex
Gelatinous cleansing compositions contain as the gelling-agent a salt of a basic compound with an acid quaternary ammonium compound <FORM:1029043/C4-C5/1> wherein R is an unsubstituted C13-17 aliphatic hydrocarbon radical, R1 and R11 are methyl or ethyl, X is Cl or Br, and n is 2 or 3.  The salts have by themselves a washing and lathering effect.  The basic compound may be an alkali metal hydroxide, ammonia, an alkanolamine or a tertiary amine <FORM:1029043/C4-C5/2> wherein R, R1 and R11 are as above.  A preferre basic compound is N,N1-dimethylaminopropyl C14-18 fatty acid amide.  The acid quaternary ammonium compound may be a N,N1-dimethylaminopropyl C14-18 fatty acid amide quaternated with chlor- or brom-acetic acids.  The examples describe a shampoo, containing, besides the gelling agent, cetyl dimethyl (2-hydroxyethyl)-ammonium chloride, of pH 7.0 in gel form, optionally perfurmed, and a washing preparation, preferably for the hands, in gel form of pH 7.7, optionally perfumed, and containing, besides the gelling agent, the sodium salt of 2-caprinyl-imidazolinium-3-ethoxy-3-acetate.ALSO:Gelatinous cosmetic, hair setting, and pharmaceutical e.g bactericidal or disinfectant compositions contain as the gelling agent a salt of a basic compound with an acid quarternary ammonium compound <FORM:1029043/A5-A6/1> wherein R is an unsubstituted C13-17 aliphatic hydrocarbon radical, R1 and R11 are methyl or ethyl, X is Cl or Br, and n is 2 or 3.  The basic compound may be an alkali metal hydroxide, ammonia, an alkanolamine or a tertiary amine <FORM:1029043/A5-A6/2> wherein R, R1 and R11 are as above.  A preferred basic compound is N,N1-dimethylaminopropyl-C14-18 fatty acid amide.  The acid quaternary ammonium compound may be a N,N1-dimethylamino propyl C14-18 fatty acid amide quaternated with chloracetic or bromacetic acid.  The gelatinous pharmaceutical compositions may contain salicylic acid, boric acid, vitamins, local anaesthetics, hormones e.g. dexamethasone trimethyl acetate and are generally applied topically.  Salve bases containing the active gelling agent and (a) polyethylene glycol and (b) the condensation product of tetrahydroabietyl alcohol and ethylene oxide are exemplified.ALSO:Gelatinous hair dyeing and oxidant compositions contain as the gelling agent a salt of a basic compound with an acid quarternary ammonium compound <FORM:1029043/D1-D2/1> wherein R is an unsubstituted C13-17 aliphatic hydrocarbon radical, R1 and R11 are methyl or ethyl, X is Cl or Br, and n is 2 or 3.  The basic compound may be an alkali metal hydroxide, ammonia, an alkalolamine or a tertiary amine <FORM:1029043/D1-D2/2> wherein R, R1, and R11 are as above.  A preferred basic compound is N, N1-dimethylaminopropyl C14-18 fatty acid amide.  The acid quarternary ammonium compound may be a N, N1-dimethylaminopropyl C14-18 fatty acid amide quarternated with chlor-or brom-acetic acids.  The examples describe (a) an oxidant for hair in gel form comprising 100% H2O2, adjusted to pH 5.2 with tactic acid, and optionally perfumed; (b) hair dyeing gels containing <FORM:1029043/D1-D2/3>
Huntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been observed that copper and iron concentrations are increased in the striata of post-mortem human HD brains. Although it has been shown that the accumulation of mutant HTT protein can interact with copper, the underlying HD progressive phenotypes due to copper overload remains elusive. Here, in a Drosophila model of HD, we showed that copper induces dose-dependent aggregational toxicity and enhancement of Htt-induced neurodegeneration. Specifically, we found that copper increases mutant Htt aggregation, enhances the accumulation of Thioflavin S positive β-amyloid structures within Htt aggregates, and consequently alters autophagy in the brain. Administration of copper chelator D-penicillamine (DPA) through feeding significantly decreases β-amyloid aggregates in the HD pathological model. These findings reveal a direct role of copper in potentiating mutant Htt protein-induced aggregational toxicity, and further indicate the potential impact of environmental copper exposure in the disease onset and progression of HD.
New born infants from various countries over the world will be followed up for up to two years for the occurrence of Lower Respiratory Tract Infections. Through active and passive surveillance, any suspected case will be identified, assessed during an examination visit and followed up until completion through a diary card. Full symptomology will be assessed during the examination visit. The disease course and all healthcare utilization will be subsequently collected through a two-week diary card and contact with ay healthcare providers involved in management of the disease. RSV detection will occur through quantitative PCR of collected nasal swabs. A baseline cord blood serum sample of all subjects and a follow-up blood serum sample from a sub-cohort will also be collected to assess antibody levels at various points in time and in relation to risk of RSV LRTI.

For extension period, pertaining to wheeze and asthma (Epoch 002): Subjects' parent(s)/LAR(s) will be asked to re-consent and subjects will be followed up through quarterly contacts up to the age of 6 years. Data collection will also occur from medical charts retrospectively for those who have a gap period between the end of the primary study and providing re-consent for the extension. The extension involves enrolment visit (at 2nd birthday \[on completion of primary study or as soon as possible thereafter\]) and quarterly surveillance contacts.
1,196,636. Serum albumin. USTAV SER A OCKOVACICH LATEK OBOROVY PODNIK. 4 Oct., 1967 [1 March, 1967], No. 45324/ 67. Heading A5B. [Also in Divisions C3] A process for the preparation of pure serum albumins from normal and haemolysted serum or plasma includes the precipitation of undesirable proteins and dyestuffs contained in the raw material by a combined denaturation action of increased temperature not exceeding 53‹C. in the presence of chloroform. In a preferred embodiment the precipitation is brought about at a pH of 4.95 to 5.05 with continuous stirring to a temperature of 50‹C., the precipitate is centrifuged, the supernatant liquid is filtered off, its pH adjusted to 6.5 to 7.0 and it is then lyophilised.
BACKGROUND: Ovarian cancer (OC) is found to be the third most common gynecologic malignancy over the world, having the highest mortality rate among such tumors. Emerging studies underscore the presence of microorganisms within tumor tissues, with certain pathogens intricately linked to disease onset and progression. Disruption of the microbiome frequently precipitates disturbances in host metabolic and immune pathways, thereby fostering the development of cancer.
METHODS: In this study, we initiated the investigation by conducting microbial reannotation on the RNA sequencing data derived from ovarian cancer tissues. Subsequently, a comprehensive array of analyses on tissue microbes was executed. These analyses encompassed the assessment of intergroup variations in microbial diversity, differential microbiological analysis, exploration of the association between host gene expression and microbial abundance, as well as an enrichment analysis of functional pathways linked to host genes associated with microbes.
RESULTS: The analysis results revealed that Proteobacteria, Actinobacteria, Firmicutes, and Bacteroidetes were the main components at phylum level in ovarian tissue. Notably, the microbial composition of ovarian cancer tissue significantly diverged from that of normal ovarian tissue e, exhibiting markedly lower alpha diversity and distinct beta diversity. Besides, pathogenic microorganisms Achromobacter xylosoxidans and Enterobacter hormaechei were enriched in cancer tissue. Host genes associated with these pathogens were enriched in key pathways including "JAK-STAT signaling pathway", "Transcriptional misregulation in cancer", and "Th1 and Th2 cell differentiation", suggesting their role in ovarian cancer progression through microbial dysbiosis and immune response interaction.
CONCLUSION: Abundance of pathogenic microorganisms in ovarian cancer tissue could modulate the expression of host genes, consequently impacting cancer-related signaling pathways and fostering cancer progression.
Subjects will be divided into one of two groups: (1) Pycrinil®/flaxseed oil or (2) Placebo/flaxseed oil twice daily with food. The two formulations will be identical in appearance and standardized by Indena, S.p.A. Patients will be enrolled for a total of 3 months (± 1 week to allow for scheduling flexibility) with a 1 month (± 1 week to allow for scheduling flexibility) first follow-up visit in between enrollment and final visits. At all visits, patients will be asked to monitor for any symptomatic ADE. The first follow-up visit will focus on medication compliance (via pill count) and safety assessment (including laboratories). The final study visit will consist of brief clinical assessment (including anthropometrics), completed lifestyle and physical activity assessments, subjective ADE reporting, and donated blood and urine for clinical laboratory tests. Medication changes are not prohibited during the study period, but must be recorded. Medication bottles will be collected at the first follow-up and final visits; pill counts will be performed to assess compliance.
The invention discloses indanone derivatives derived from marine fungi and a preparation method and application of the indanone derivatives. The structural formula of the indanone derivatives is represented by the following formulae (I and II shown in the description), wherein R represents H or Me. The indanone derivatives are separated from marine halodrymium endophytic fungi Ascomycota sp. SK2YWS-L. The strain is preserved in China Center for Type Culture Collection on April 21, 2016 with the preservation number of CCTCC M 2016217. The indanone derivatives have the capacities of reducing trivalent iron ions in vitro and clearing the activities of DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals and hydroxyl free radicals as well as a very good application prospect in the preparation of antioxidant drugs or health products.
The study took place in the District of Dschang, Cameroon. Women aged between 30 and 49 years, addressed to undergo a pelvic examination with VIA and VILI, were invited to participate. Throughout the examination, one part of the women underwent the routine VIA/VILI, with no visual support (control group), whereas the other part of patients were shown the pictures of the cervix in real-time on a digital screen (study group). At the end of the procedure, all women had the possibility to see the pictures retrospectively. Randomization determined the women's distribution between the two groups. Their anxiety level was measured by asking them to complete the Spielberg's State Anxiety Inventory (STAI) both prior to and immediately after the procedure.
Particulate matter (PM10) changes have been confirmed as one of the contributory factors affecting human health, the association between PM10 pollution and the hospitalization of chronic obstructive pulmonary disease (COPD) with comorbidity diseases was rarely reported. The same inpatient more than twice times admissions with COPD illness from January 1, 2016 to December 31, 2021 were identified from hospitals in the 17 cities of Henan, Central China. City-specific associations were firstly estimated using the case time series (CTS) model and then combined to obtain the regional average association. The multivariate meta-analytic model produces pooled estimates of the set of coefficients representing the PM10-COPD hospitalizations association across the 17 cities. Cause-specific hospitalization analyses were performed by COPD patients with different comorbidity combinations. A total of 34,348 elderly (age ≥ 65) subjects were analyzed and with a total of 35,122.35 person-years. These coefficients can be used to compute the linear exposure-response curve expressed as relative risk (RR) in per 10 µg/m3 increase in PM10 at lag03, which was 1.0091 (95% CI 1.0070-1.0112) for COPD with comorbidity, 1.0089 (95% CI 1.0067-1.0110) for COPD with circulatory system diseases, 1.0079 (95% CI 1.0052-1.0105) for COPD with respiratory system diseases, 1.0076 (95% CI 1.0032-1.0121) for COPD with endocrine system diseases, and 1.0087 (95% CI 1.0013-1.0162) for COPD with genitourinary system diseases, respectively. Some heterogeneity was found across cities, with estimates ranging from 1.0227 in the Puyang and Jiaozuo to 1.0053 in Henan Provance, China. The effect of higher PM10, on average, was higher in studies for northern cities, with a steeper raise in risk: per 10 µg/m3 increase in PM10, the RR from 1.0062 (95% CI 1.0030-1.0093) for the 10th percentile of latitude to 1.0124 (95% CI 1.0089-1.0160) for the 90th percentile. Our findings indicated that PM10 exposure may increase the risk of hospitalizations for COPD with comorbidity. Moreover, there might be a higher morbidity risk associated with PM10 in northern latitudes, indicating that stricter air quality standards could potentially reduce PM10-related morbidity among individuals with COPD. These findings have implications for the implementation of effective clean air interventions aligned with national climate policies.
BACKGROUND: The intake of dietary antioxidants and glycolipid metabolism are closely related to chronic kidney disease (CKD), particularly among individuals with abdominal obesity. Nevertheless, the cumulative effect of multiple comorbid risk factors on the progression and complications of CKD remains inadequately characterized.
METHODS: This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) dat abase (2005-2018), to examine potential factors related to CKD, including glycolipid metabolism, dietary antioxidant intake, and pertinent medical history. To explore the associations between these variables and CKD, the present study used a multivariable-adjusted least absolute shrinkage and selection operator (LASSO) regression model, along with a restricted cubic spline (RCS) model. Furthermore, an optimal predictive model was developed for CKD using ten machine learning algorithms and enhanced model interpretability with the Shapley Additive Explanations (SHAP) method.
RESULTS: A cohort comprising 8,764 eligible individuals (52% male, including 1,839 CKD patients) with abdominal obesity aged 20-85 years were included. The findings revealed significant positive correlations in patients with abdominal obesity between the presence of CKD and age, a history of heart failure, hypertension, diabetes, elevated lipid accumulation product (LAP) and triglyceride glucose-waist circumference (TyG-WC) levels. Conversely, negative correlations were identified between CKD and variables such as sex, high-density lipoprotein cholesterol (HDL-C) levels, and the composite dietary antioxidant index (CDAI). In parallel, RCS regression analysis revealed significant nonlinear associations between the CDAI, HDL-C, TyG-WC, and CKD among patients with abdominal obesity aged 60-80 years. The development of predictive models demonstrated that the CatBoost model surpassed other models, achieving an accuracy of 86.74% on the validation set. The model's area under the receiver operator curve (AUC) and F1 score were 0.938 and 0.889, respectively. The SHAP values revealed that age was the most significant predictor, followed by diabetes history, hypertension, HDL-C levels, CDAI index, TyG-WC, and LAP.
CONCLUSION: CatBoost models, along with glycolipid metabolism indexes and dietary antioxidant intake, are effective for early CKD detection in patients with abdominal obesity.
PURPOSE: A moisturizer containing Dictamnus dasycarpus Turcz. and Sasa borealis extract is provided to safely treat bacterial dermatitis and itchiness. CONSTITUTION: A natural moisturizer contains Dictamnus dasycarpus Turcz. and Sasa borealis extract. A method for manufacturing the natural moisturizer comprises: a step of collecting and cutting Dictamnus dasycarpus Turcz. and Sasa borealis; a step of adding 1000g of water to 30-50g of Dictamnus dasycarpus Turcz. and Sasa borealis; a step of adding 3-5g of grape seed oil and soaking at 85-95°C for 12-72 hours; a step of removing solids and filtering; a step of mixing with a natural perfume; and a step of being packed in a spray container.
Bananas (Musa spp.) are among the most important fruit and staple food crops globally, holding a significant strategic position in food security in tropical and subtropical regions. However, the industry is grappling with a significant threat from Fusarium wilt, a disease incited by Fusarium oxysporum f. sp. cubense (Foc). In this study, we explored the potential of Piriformospora indica (Pi), a mycorrhizal fungus renowned for bolstering plant resilience and nutrient assimilation, to fortify bananas against this devastating disease. Through a meticulous comparative analysis of mRNA and miRNA expression in control, Foc-inoculated, Pi-colonized, and Pi-colonized followed by Foc-inoculated plants via transcriptome and sRNAome, we uncovered a significant enrichment of differentially expressed genes (DEGs) and DE miRNAs in pathways associated with plant growth and development, glutathione metabolism, and stress response. Our findings suggest that P. indica plays a pivotal role in bolstering banana resistance to Foc. We propose that P. indica modulates the expression of key genes, such as glutathione S-transferase (GST), and transcription factors (TFs), including TCP, through miRNAs, thus augmenting the plant's defensive capabilities. This study offers novel perspectives on harnessing P. indica for the management of banana wilt disease.
A mechanism for providing inventory information from distributed computing resources in an enterprise network in a manner that minimizes network traffic being sent from those computing resources to a centralized inventory server is provided. Bandwidth minimization is performed by generating a value corresponding to identifying information for each item inventoried on a computing resource and transmitting only those values to the inventory server. The generated value is shorter than a string containing the detailed information regarding the inventoried item, but is unique to that item. The inventory server then only requests more detailed information about an individual inventory item if a reported value has not previously been reported to the inventory server. In this manner, detailed information about a specific inventoried item is only transmitted through the network the first time that the item is inventoried and reported from any computer in the network. For any subsequent nodes reporting the same inventoried item, only the value is transmitted through the network and recorded within the inventory server. This avoids transmitting detailed information about each inventoried item for each computer during each computer report to an inventory server, thereby reducing network traffic.
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.