anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Deceased organ donation saves lives. Donation processes in New Zealand operate under an opt-in system, which requires consent from families of patients diagnosed with brain death or circulatory death while in the intensivecare unit. The donation demand and supply mismatch is a global phenomenon.
OBJECTIVES: The objective of this study was to understand the determinants of deceased organ donation decisions in the adult intensive care setting from the perspectives of staff and families.
METHODS: An integrative review based on Whittemore and Knafl's approach searched literature through databases CINAHL Plus, SCOPUS, Proquest Medline Ovid, and manual ancestry searches. Inclusion/exclusion criteria screened for pertinent literature, which were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Selected studies were appraised using a generic scoring tool, and data were systematically extracted and coded onto spreadsheets using inductive, thematic analysis.
RESULTS: A total of 21 studies (12 qualitative, seven quantitative, two mixed methods) were included. Publication dates ranged from 1993 to 2021 from multiple countries (18 opt-in, three opt-out systems). Four overarching themes pertaining to families and staff were generated. Important knowledge related to families' knowledge deficits around brain death, the purpose of ventilation, donation procedures, patients' wishes, and staffs' lack of training. Challenging communication highlighted miscommunications due to language choices and interrupted continuity of care during staff-family interactions. Internal determinants explored the cultural, spiritual, and emotional perspectives of families, while staff faced a sense of burden and conflicting values in delivering care between donors and recipients. External determinants related to the clinical environment impacting on grieving families, while for the staff, it explained concerns around resources and organisational processes.
CONCLUSIONS: Factors underpinning deceased organ donation are multifaceted and complex. Staff actions and families' decisions are inextricably intertwined. Modifiable factors include a lack of formal training and communicational skills and environmental limitations of an intensive care setting.
The present invention relates to a mixture of the extract of ginger and dried tangerine peel for treating cardiovascular diseases. The composition of the weight parts is 100 of ginger extract and 0.1 to 200 of dried tangerine peel extract, wherein the ginger extract is supercritical carbon dioxide extract of the root of ginger, and the dried tangerine peel extract is steam distillation extract of the mature peel of tangerine and cultivated varieties thereof. The mixture mainly contains ginger volatile oil, gingerol and dried tangerine peel volatile oil. The present invention has the functions of free radical oxidation resistance, protection of cardiac muscle cells, adjustment of blood pressure, improvement of hemorheology, coagulation resistance, thrombosis resistance, oxygen deficiency resistance, etc. The present invention uses the mixture of the extract of ginger and dried tangerine peel as active ingredients for being combined with suitable excipient, and various medicinal preparations are prepared, such as soft capsules, capsules, drop pills, tablets, granules, oral liquid and injections. The present invention is used for various cardiovascular diseases, especially for treating myocardial ischemia and atherosclerosis.
Cervical cancer, among the deadliest cancers affecting women globally, primarily arises from persistent infection with high-risk human papillomavirus (HPV). To effectively combat persistent infection and prevent the progression of precancerous lesions into malignancy, a therapeutic HPV vaccine is under development. This study utilized an immunoinformatics approach to predict epitopes of cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) using the E6 and E7 oncoproteins of the HPV16 strain as target antigens. Subsequently, through meticulous selection of T-cell epitopes and other necessary elements, a multi-epitope vaccine was constructed, exhibiting good immunogenic, physicochemical, and structural characteristics. Furthermore, in silico simulations showed that the vaccine not only interacted well with toll-like receptors (TLR2/TLR3/TLR4), but also induced a strong innate and adaptive immune response characterized by elevated Th1-type cytokines, such as interferon-gamma (IFN-γ) and interleukin-2 (IL2). Additionally, our study investigated the effects of different immunization intervals on immune responses, aiming to optimize a time-efficient immunization program. In animal model experiments, the vaccine exhibited robust immunogenic, therapeutic, and prophylactic effects. Administered thrice, it consistently induced the expansion of specific CD4 and CD8 T cells, resulting in substantial cytokines release and increased proliferation of memory T cell subsets in splenic cells. Overall, our findings support the potential of this multi-epitope vaccine in combating HPV16 infection and signify its candidacy for future HPV vaccine development.
Thymic epithelial tumours show characteristic cytological features on fine-needle aspiration cytology, however the cytological features of thymoma in fluid cytology are not well described. We present the case of a 77 year-old-woman with known pleural dissemination of type B2/B3 thymoma presenting with shortness of breath and orthopnoea due to a pleural effusion. Cytological evaluation of the pleural fluid showed cellular smears composed of numerous small lymphocytes with small numbers of admixed mesothelial cells. There was no epithelial component. On immunohistochemical (IHC) staining the lymphocytes were T cells which were positive for CD3. CD1a and terminal deoxynucleotide transferase (TdT) were also positive, consistent with immature lymphocytes of thymic origin. Despite the lack of an epithelial component, this case was diagnosed as suspicious for recurrent/ metastatic thymoma. This is only the second published case of thymoma identified on pleural fluid cytology, and to our knowledge the first case describing thymoma in pleural fluid with no epithelial component, a potential pitfall with the more common differential diagnosis of a reactive lymphocytic effusion.
Patients in whom an Indication Biopsy (IB) is to be performed due to suspicion of rejection. This cohort may be recruited in all sites participating in the study, including sites where annual protocol biopsies are not routinely performed. An IMBG will be performed coinciding with the IB. This cohort will include patients who have had their transplant for less than 5 years.
Participants in this group will receive physiotherapy sessions with a maximum frequency of 2 weekly sessions, as defined by the physiotherapist, according to personalized therapeutic plans for a period of 2 months. The physiotherapy approach for patients with long COVID includes motor and respiratory rehabilitation aiming at maintaining and/or improving joint mobility, muscle strength, and functional exercise capacity (Thomas et al., 2020). At each visit, the participants respond by self-report about their general condition. Depending on the case, the physiotherapist will perform a reevaluation with specific tests. The PT group will receive physiotherapy treatment offered by five physiotherapists, with more than 5 years of experience each, duly registered with their class council. the treatment provided will be registered on each participant's clinical notes and a summary of main interventions will be reported.
Various endogenous and exogenous stimuli can result in an inflammatory response and collagen deposition in the liver, which affect liver function and increase the risk of developing liver cirrhosis and cancer. Rice bran, the main by-product of rice milling, contains various nutrients which possess hepatoprotective activities. In this study, we investigated the effects of rice bran on carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Mice were fed a rice-bran-containing diet (10% rice bran w/w) or a standard diet with or without an injection of 20% CCl4 to induce liver fibrosis. Our results showed that feeding a rice-bran-containing diet could alleviate CCl4-induced liver damage, collagen deposition, and expressions of fibrosis-related genes, including α-smooth muscle actin (α-SMA), collagen 1a2 (COL1A2), and transforming growth factor-β (TGF-β) in liver tissues. Moreover, consumption of rice bran enhanced phase II detoxification and antioxidant gene expressions, including Gsta3, Gstp1, Catalase, SOD1, SOD2, and SOD3. Treatment with γ-oryzanol, the major bioactive compound in rice bran, decreased the sensitivity of hepatic stellate cells (HSCs) to TGF-β1-induced α-SMA, COL1A2, and phosphorylated smad2 expressions. In conclusion, a rice-bran-containing diet may have beneficial effects on liver fibrogenesis through increased antioxidant and detoxification activities. γ-Oryzanol, the major bioactive compound of rice bran, can inhibit activation of HSCs.
PURPOSE:To obtain a bathing agent containing an alginic acid propylene glycol ester or further an N-acylamino acid salt, effective for smoothing the skin in bathing and giving moist skin after bathing. CONSTITUTION:This bathing agent contains 1-5wt.% of algins extracted from sea algae or an alginic acid propylene glycol ester easily producible by esterifying the algin with propylene glycol. As an alternative, this bathing agent is produced by adding an N-acylamino acid salt (salt of N-acylated product of an amino acid such as sarcosine, alanine and glutamic acid) to an alginic acid propylene glycol ester. The bathing water incorporated with the bathing agent has improved mildness to the skin. The amount of the N-acylamino acid salt is preferably 1-3wt.%. The bathing agent containing the propylene glycol alginate is resistant to coagulation and precipitation even in a bathing water having high hardness.
### Renal Toxicity

Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. 

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.

No information is available from controlled clinical studies regarding the use of mefenamic acid in patients with advanced renal disease. The renal effects of mefenamic acid may hasten the progression of renal dysfunction in patients with pre-existing renal disease.

Correct volume status in dehydrated or hypovolemic patients prior to initiating mefenamic acid. Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia during use of mefenamic acid (see Precautions; Drug Interactions). Avoid the use of mefenamic acid in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal function. If mefenamic acid is used in patients with advanced renal disease, monitor patients for signs of worsening renal function. 

### Hyperkalemia

Increases in serum potassium concentration, including hyperkalemia, have been reported with use of NSAIDs, even in some patients without renal impairment. In patients with normal renal function, these effects have been attributed to a hyporeninemic-hypoaldosteronism state.
1328854 Polymerizable dental materials MINNESOTA MINING & MFG CO 2 Nov 1970 [3 Nov 1969] 52071/70 Addition to 1267448 Heading C3P  Mouldable dental restorative compositions having a moisture absorption, after hardening and exposure to moisture, of less than 1% by weight, comprise an inorganic particulate filler and a liquid binder capable of being polymerized in the presence of a free radical initiator, the binder comprising a monomeric polyacrylate or polymethacryate ester of an etherified diphenol which has been etherified at each phenolic hydroxyl group by a molecule of a diol or triol, the diphenol group comprising at least two aromatic nuclei joined directly through a single carbon-carbon bond or through a divalent linking group, and the polyester being substantially free from active hydrogen atoms and devoid of peroxides. A polymerization accelerator is preferably also included, e.g. an N,N-bis- (hydroxyalkyl) - p - toluidine or -3,5 - xylidene wherein the alkyl group has 2 to 6 carbon atoms. Suitable fillers include lithium aluminium silicates, hydroxy apatite, silica or siliceous materials, alumina or aluminoferrous materials, and glasses such as borosilicate glasses; the filler may be modified to promote adhesion by the binder, e.g. by a conventional vinyl silane treatment. Small amounts of pigment may be included in the filler for visual colour or fluorescent effect. The polymerizable ester is preferably one of the formula in which M is a methacryloyl or acryloyl group, D is C 2 -C 6  alkylene, X is the nucleus of a diphenol having at least two aromatic nuclei joined as described above and having from 12-24 carbon atoms, T is the nucleus of a triprimary triol and n is an integer. The compositions can be stored in two-component kit form with the ingredients of the composition being apportioned between the two components. In examples an adduct of glycidyl methacrylate and phenyl salicylate is used as a comonomer for the binder, and benzoyl peroxide is used as polymerization initiator.
Iodine seeds are produced by forming an intermediate by introducing anions of phosphate, oxalate or arsenate onto the surface of a support, and then substituting the anions with I-125. The method may allow a high substitution effect of iodine. The support may be silver, ceramic containing silver or a heavy metal surface treated with silver. The iodine seed may be sealed with titanium. Silver wire was treated with sodium phosphate; subsequent treatment with I-125 gave the iodine seeds. Similarly seeds were produced using sodium oxalate or sodium arsenate. The iodine seeds may be useful for the treatment of eye disease or prostate cancer.
Participants first received 5 thin condoms, and had a period of 2-4 weeks to use them. They then received 5 fitted condoms, and had a period of 2-4 weeks to use them. They then received 5 standard condoms, and had a period of 2-4 weeks to use them.
Urocortin (Ucn) is a native mammalian peptide generally related to Urotensin I  and Corticotropin Releasing Factor (CRF). Human Ucn has the formula: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (SEQ ID NO:15). Rat-derived Ucn is identical but for 2 substitutions, Asp2 for Asn2 and Pro4 for Ser4. Ucn or analogs thereof or pharmaceutically acceptable salts can be administered to humans and other mammals to achieve substantial elevation of ACTH, .beta.-endorphin, .beta.-lipotropin, other products of the pro-opiomelanocortin gene and corticosterone. They can also be used to lower blood pressure over an extended period of time, as stimulants to elevate mood and to improve memory and learning performance, as well as diagnostically. Shortened fragments may be administered to release endogenous CRF and/or Ucn in the brain and peripherally. Ucn antagonists can be used to block the action of Ucn and/or CRF, as can antibodies to Ucn. Labelled Ucn agonists and antagonists can be used in drug screening assays along with CRF  receptors; they may also be used diagnostically along with Ucn antibodies.
The patients in this arm will recieve neoadjuvant chemotherapy with preoperative radiotherapy concurrently with taxanes. Surgery is done 6-8 weeks as indicated, followed by systemic treatment according to the guidelines.
PROBLEM TO BE SOLVED: To obtain the subject composition having good retaining force, never causing transfer, excellent in water resistance, capable of comfortably applying and capable of forming flexible coating free from tackiness and having gloss and useful for cosmetic, etc. SOLUTION: This cosmetic composition for topical application comprises (A) a liquid fat phase (e.g. carbon-based oil derived from minerals, animals, plants or synthetic materials, a hydrocarbon-based oil, a fluorinated oil or a silicone oil) and (B) a dye (e.g. filler, pigment or pearl brightener). The composition is obtained by dispersing polymer particles (e.g. particles of a film-forming polymer such as polyurethane or polyurea) in the interface is stabilized by a stabilizer (e.g. silicone polymer whose hydrocarbon-based chain is grafted) in an amount of >=2 wt.% based on total weight of the composition into the component A.
The present invention relates to a pediatric vision recovery and presbyopia recovery system through smart glasses, a smartphone, and a smartwatch. In the pediatric vision recovery and presbyopia recovery system through smart glasses, a smartphone, and a smartwatch, a personal terminal (1-1 to 1-N), a hospital (or oriental medicine hospital included) computer (2-1 to 2-N), and an operator computer server (3) are connected to each other through a wired or wireless communication network. A smartwatch (430 or 530) capable of Bluetooth communication with the personal terminal (1-1 to 1-N) is provided. Smart glasses (or vision correction glasses or glasses without lenses) equipped with a QR code and having a Bluetooth function and the smartwatch (430 or 530) can communicate with each other through Bluetooth. The hospital computer (2-1 to 2-N) is equipped with a vision recovery program storage unit (330). The vision recovery program storage unit (330) is provided in the form of an application (APP) and can be downloaded and installed on the personal terminal (1-1 to 1-N) and can also be downloaded and installed from the operator server (3). When an individual wears smart glasses, and the smart glasses, smartphone, and smartwatch are connected to each other via Bluetooth, a vision recovery program is run through the smartphone (or smartwatch) with the vision recovery program downloaded to perform an individual vision recovery exercise for a certain period of time according to voice and display instructions of the vision recovery program, thereby recovering one's vision.
Tumor hypoxia impairs the generation of reactive oxygen species and the induction of immunogenic cell death (ICD) for photodynamic therapy (PDT), thus impeding its efficacy and the subsequent immunotherapy. In addition, hypoxia plays a critical role in forming immunosuppressive tumor microenvironments (TME) by regulating the infiltration of immunosuppressive tumor-associated macrophages (TAMs) and the expression of programmed death ligand 1 (PD-L1). To simultaneously tackle these issues, a MnO2-containing albumin nanoplatform co-delivering IR780, NLG919, and a paclitaxel (PTX) dimer is designed to boost photodynamic immunotherapy. The MnO2-catalyzed oxygen supply bolsters the efficacy of PDT and PTX-mediated chemotherapy, collectively amplifying the induction of ICD and the expansion of tumor-specific cytotoxic T lymphocytes (CTLs). More importantly, hypoxia releif reshapes the immunosuppressive TME via down-regulating the intratumoral infiltration of M2-type TAMs and the PD-L1 expression of tumor cells to enhance the infiltration and efficacy of CTLs in combination with immune checkpoint blockade (ICB) by NLG919, consequently eradicating primary tumors and almost completely preventing tumor relapse and metastasis. This study sets an example of enhanced immunotherapy for breast cancers through dual ICD induction and simultaneous immunosuppression modulation via both hypoxia relief and ICB, providing a strategy for the treatment of other hypoxic and immunosuppressive cancers.
The recommended ketamine dose of 0.5 mg/kg will be administered using a transmucosal route of administration wherein the subject will be instructed to place the liquid solution beneath their tongue and hold it in their mouth for 5 minutes. The pharmacy will prepare two 0.5 mg/kg solutions of ketamine in two syringes for each subject based on subject weight. For example, a 70 kg adult subject will receive a 0.35 mL solution of ketamine. The patient will receive a dose every 7 days for two weeks, for a total of two doses.
Macrophage polarization and inflammation may play an important role in the development of sepsis. T-cell immunoglobulin mucin 1 (TIM1) has been demonstrated to promote macrophage inflammatory responses. However, whether TIM1 regulates macrophage polarization and inflammation to affect sepsis development remains unclear. Human monocytic leukemia cell line was induced into macrophages, followed by stimulated with LPS and IL-4 to induce M1 polarization and M2 polarization. The expression levels of TIM1, methyltransferase 3 (METTL3), and insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) were examined by qRT-PCR and western blot. IL-6, IL-1β, and TNF-α levels were tested by ELISA. CD86+cell rate was analyzed by flow cytometry. The m6A methylation level of TIM1 was assessed by MeRIP assay. The interaction of between TIM1 and METTL3 or IGF2BP2 was assessed by dual-luciferase reporter assay and RIP assay. TIM1 knockdown repressed LPS-induced macrophage M1 polarization and inflammation. In terms of mechanism, METTL3 promoted TIM1 expression through m6A modification, and this modification could be recognized by IGF2BP2. Besides, knockdown of METTL3/IGF2BP2 suppressed LPS-induced macrophage M1 polarization and inflammation, while this effect could be eliminated by TIM1 overexpression. METTL3/IGF2BP2/TIM1 axis promoted macrophage M1 polarization and inflammation, which might provide potential target for sepsis treatment.
Radiation with protons normofractionated 54-60 Gy(RBE). Not pre-irradiated patients.
* Purpose: The direct anterior approach to the hip has been suggested to have several advantages compared to previously classical approaches. However, no studies focused on the effects of these different surgeries on patients' perception recovery and walking efficiency according the initial physical fitness. Therefore, the purpose of this study is to compare the effects of surgical procedures on perceptual walking skills and efficiency according to the patients' physical fitness.
* Abstract : Some earlier studies report differences between surgery types in self- reported mobility, functional recovery and residual hip pain. The direct anterior approach to the hip has been suggested to have several advantages compared to previously popular approaches through its use of an intra-muscular and intra-nervous interval between the tensor fasciae latae and sartorius muscles. However, patients' physical fitness, postural response and perceptual walking skill relation was not taking account. 80 patients will be tested, one before and at various times after hip surgery. In randomized conditions, our patients will be divided in two groups, according the surgery approaches and their physical fitness. All patients performed a Performance-Oriented Mobility Assessment Walking test with and without step and the PMA, Harris, Oxford 12 and Womac scores will be evaluated before, 3 weeks, 6 weeks, 3 months and 1 year after the surgery. During the Performance-Oriented Mobility Assessment Walking test, self-reported walking capacity, rating of exertion perception and walking parameters will be measured.