anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject composition including a naturalized synthetic organic germanium compound-containing honey which prevents the function for masticating and absorbing foods and the like from deterioration by controlling intraoral allergy. SOLUTION: The dentifrice composition including a naturalized synthetic organic germanium-containing honey is obtained. In order to stabilize the concentration of organic germanium in the naturalized synthetic organic germanium- containing honey, β-carbodxyethylgermainum sesquioxide is dissolved into a sucrose water, invertase (e.g. β-fructofuranoside and β-glucosidase) of honey bee enzyme, diastase and glucose oxidase are added into the solution under mixing for a fixed period of time and then mixed with honey, and the mixture is fed to honey bees to collect honey. It is suitable to be added into dentifrice in an amount of 0.5-5.0 wt.%. This composition possesses the function of preventing gum from bleeding ad it is convenient to continuously use as a countermeasure against oral allergy which is caused by fruits and vegetables and worried about the increase.
The present invention relates to DNA enzymes of type 10-23 with certain modifications of specific nucleotides in the core sequence rendering the DNA enzymes particularly stable and additionally exhibiting substantially the same or a higher cleavage efficiency with respect to their substrate when compared against the corresponding unmodified DNA enzymes. The present application further provides host cells containing the DNA enzymes according to the invention. In addition there is provided a pharmaceutical formulation which contains the DNA enzymes or host cells according to the invention. The DNA enzymes and further subjects are directed in particular against the vanilloid receptor 1 (VR1), or picornaviruses. The present invention further provides small interference RNA molecules (siRNA) directed against VR1, and host cells containing the siRNA. The siRNA and corresponding host cells are suitable as pharmaceutical formulations or for the preparation of pharmaceutical formulations, in particular for the treatment of pain and other pathological conditions associated with VR1.
Participants in this intervention group complete at-home heart rate variability biofeedback (HRVB) training using a chest-worn heart rate monitor and a smartphone app. They complete at least 10 minutes per day of HRVB training on at least 5 days per week for 3 weeks.
Treatment with Vericiguat will be uptitrated every two weeks to the highest tolerated dose, with a target maintenance dose of maximum 10 mg once daily. After a washout period of 2 weeks, matching placebo will be started and is uptitrated every two weeks to maintain double blinding.
INTRODUCTION: The COVID-19 pandemic has been associated with significant variability in acute kidney injury (AKI) incidence, leading to concerns regarding patient heterogeneity. The study's primary objective was a cluster analysis, to identify homogeneous subgroups of patients (clusters) using baseline characteristics, including inflammatory biomarkers. The secondary objectives were the comparisons of MAKE-90 and mortality between the different clusters at three months.
METHODS: This retrospective single-center study was conducted in the Medical Intensive Care Unit of the University Hospital of Clermont-Ferrand, France. Baseline data, clinical and biological characteristics on ICU admission, and outcomes at day 90 were recorded. The primary outcome was the risk of major adverse kidney events at 90 days (MAKE-90). Clusters were determined using hierarchical clustering on principal components approach based on admission characteristics, biomarkers and serum values of immune dysfunction and kidney function.
RESULTS: It included consecutive adult patients admitted between March 20, 2020 and February 28, 2021 for severe COVID-19. A total of 149 patients were included in the study. Three clusters were identified of which two were fully described (cluster 3 comprising 2 patients). Cluster 1 comprised 122 patients with fewer organ dysfunctions, moderate immune dysfunction, and was associated with reduced mortality and a lower incidence of MAKE-90. Cluster 2 comprised 25 patients with greater disease severity, immune dysfunction, higher levels of suPAR and L-FABP/U Creat, and greater organ support requirement, incidence of AKI, day-90 mortality and MAKE-90.
CONCLUSIONS: This study identified two clusters of severe COVID-19 patients with distinct biological characteristics and renal event risks. Such clusters may help facilitate the identification of targeted populations for future clinical trials. Also, it may help to understand the significant variability in AKI incidence observed in COVID-19 patients.
Background and Objectives: Self-management programs are essential for increasing COPD patient participation and autonomy in making appropriate decisions about their chronic condition. The present study aimed to assess the impact of COPD self-management interventions on quality of life, functional status, patient education, depression, and anxiety in primary care. Materials and Methods: We conducted a randomized controlled trial recruiting patients with COPD (GOLD A and B) from four primary care centers in Crete, Greece, with one intervention group (n = 40) receiving self-management educational support and one control group (n = 80) receiving usual care. To measure quality of life, functional status, patient education, depression, and anxiety, we used patient-reported outcome measures (PROMs) at baseline and 6 months post-intervention, including the Short-Form Health survey (SF-12), Clinical COPD Questionnaire (CCQ), mMRC, Beck Anxiety Inventory (BAI), Beck Depression Inventory, Health Education Impact Questionnaire (HeiQ), and Health Literacy Questionnaire (HLQ). Results: At the end of the 6-month intervention, most PROMs improved significantly in the intervention group (p < 0.05) but did not show significant changes in the control group. The greatest improvements at follow-up compared to baseline measurements were observed for dyspnea (mMRC-38.6%), anxiety (BAI-35%), depression (BDI-20.2%), COPD health status (CCQ-34.1%), and the actively managing my health subscale of HLQ (23.5%). Conclusions: Our results suggest that a self-management intervention could be an effective strategy for improving PROMs in primary care. Although more research is needed to identify the long-term effects of such interventional programs, policymakers could implement similar programs to improve the overall health of these patients.
The neurological function of all subjects was assessed based on the following tests under the guidance of a physician. The timed up-and-go test was used to evaluate the subjects' gait function, requiring them to stand up from their seat and walk straight forward for 3 meters, turn around, walk straight back to the chair, and then sit down again. Using simple cognitive evaluation (Mini-Cognitive Assessment) screening of the subjects' memory and executive function, the participants will first be asked to remember three unrelated words and immediately repeat the three words; they will then be asked to draw a clock marked with the numbers and pointers, and eventually recall the three words. The verbal function of the subjects will be assessed using the verbal retelling items in the MMSE and Montreal Cognitive Assessment, asking the subjects to clearly repeat "44 stone lions," "I only know Zhang Liang came to help today," and "the cat always hid under the sofa when the dog was in the room." Through the camera image data record, the intelligent system uses the built-in intelligent algorithm for intelligent video gait recognition and neural networks based on depth interpretation automation and automatic access to the subjects' gait characteristics (stand-up time, turnaround time, stride length, step velocity, stride length, step width, etc.), language features (pronunciation, intonation, word order, language accuracy, language fluency, etc.), and clock features.
<P>PROBLEM TO BE SOLVED: To provide an antibody which can be used for diagnosis, prognosis, and effective treating of cancer especially of metastatic cancer.  <P>SOLUTION: The invention discloses as follows. The identifying and formation of the antibody which is specifically combined to a TMEFF2 protein in connection with cancer. The antibody is an antibody combined with a fluorescent label, radioisotope, and effector component chosen from the group consisting of a cytotoxicity chemical substance (auristatin). Moreover, the antibody is an antibody fragment or humanized antibody, and is an antibody chosen from the group consisting of antibodies which are produced by a cell line which has an ATCC accession number of PTA-4127. A pharmaceutical composition especially useful in order to treat prostate cancer.  <P>COPYRIGHT: (C)2011,JPO&INPIT
AIM: To retrospectively study the therapeutic modalities of primary breast sarcomas in view of the data of a local Tunisian experience.
METHODS: It is a monocentric, descriptive, retrospective study including 13 cases of primary breast sarcoma treated over a period of 25 years (1995-2020) in the oncological radiotherapy department of a university hospital in Sousse, Tunisia.
RESULTS: In our study, 13 cases of non-metastatic breast sarcomas that has been identified, divided into ten cases of phyllodes sarcomas and three cases of non-phyllodes sarcomas.Surgically, all our patients had a mastectomy. Among them, seven underwent a lymph node procedure: five underwent axillary lymph node dissection, and two others had primary axillary lymph node biopsy. For the adjuvant treatment, all the patients included in our study received radiotherapy and seven received chemotherapy. Local recurrence occurred on the operative scar in one patient after completion of radiation therapy. Metastatic relapse was described in five patients. The time to onset of metastases varied between two months and five years. Nevertheless, a complete remission was noted in 6 patients with a follow-up varying from four years to 20 years. Two patients were lost to follow-up.
CONCLUSION: Breast sarcomas remain a very rare entity of aggressive tumors.The therapeutic approach is poorly codified. For this reason, the therapeutic decision should always be discussed in a multidisciplinary assessment.
OBJECTIVE: To summarize mid-term effectiveness of modified arthroscopic suture button fixation Latarjet procedure for treatment of recurrent anterior shoulder dislocations.
METHODS: Between January 2018 and October 2020, 30 patients with recurrent anterior shoulder dislocations were treated with modified arthroscopic suture button fixation Latarjet procedure. There were 19 males and 11 females with an average age of 27.3 years (range, 18-41 years). The shoulder dislocation occurred 3-7 times, with an average of 4.9 times. The time from the last dislocation to operation was 3-10 days, with an average of 4.1 days. Glenoid defects exceeded 20% in all cases. There were 27 cases of Hill-Sachs lesions. The joint pain and function were estimated by visual analogue scale (VAS) score, University of California, Los Angeles (UCLA) score, Rowe score, American Association for Shoulder and Elbow Surgery (ASES) score, Walch-Duplay score, and the range of external rotation at 0° and external rotation at 90° abduction of shoulder before operation and at 1 month, 6 months, and last follow-up. The X-ray film, CT scan and three-dimensional reconstruction were reviewed to observe the position, healing, and absorption of the coracoid graft, correction of glenoid defect, and joint degeneration.
RESULTS: The operation time ranged from 51 to 79 minutes, with an average of 68.4 minutes. All incisions healed without complications such as nerve or blood vessel injury. All patients were followed up 36-60 months with an average of 44.6 months. The VAS score, UCLA score, Rowe score, ASES score, Walch-Duplay score, and the range of external rotation at 0° and external rotation at 90° abduction after operation significantly improved when compared with preoperative values ( P<0.05). All indicators further improved with time, and the differences between different time points after operation were significant ( P<0.05). Imaging review showed that the coracoid graft was located in the anteroinferior glenoid at 1 day after operation, and no occurrence of shoulder osteoarthritis was found during follow-up. The anatomical structure of the glenoid was normal, and no delayed healing or non-union of the coracoid graft occurred. At 20 months after operation, arthroscopic re-exploration was performed in 1 case due to fracutre caused by falling injury revealed the good shaping of the coracoid graft, smooth glenoid, and no bone resorption or osteoarthritis.
CONCLUSION: For recurrent anterior shoulder dislocations, the modified arthroscopic suture button fixation Latarjet procedure can obtain good recovery of shoulder function and low incidence of complications and has a good mid-term effectiveness.
There is concern that about half of patients with elective knee surgery report severe knee pain immediately after surgery. Optimal postoperative knee analgesia is important not only for patient comfort and satisfaction, but also to accelerate mobilization, functional recovery, and hospital discharge. To facilitate earlier ambulation and provide superior pain control, while striving for shorter hospital stays and same-day discharge for patients There is an increasing emphasis on multimodal analgesia and motor sparing regional anesthesia blocks.

To compare the postoperative analgesic efficacy of ipack adductor canal and femoral popliteal sciatic blocks in elective knee surgeries, and the first mobilization (bromage 0) times of motor block after spinal anesthesia. Our primary aim is to compare the ipack adductor canal block added after spinal anesthesia in elective knee surgeries with the combination of femoral + popliteal sciatic block. post of blocks To evaluate the operative mobilization (bromage 0) and analgesia times. Our secondary aims are to evaluate the first 4, 8, 12, 24 hours VAS (visual analog scale) values, first analgesia time, post op 1 hour bromage scores, postoperative nausea, vomiting, and discharge times, side effects. compare the incidence of effects.
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to the novel compound, 4-amino-2-(4-methyl- piperazine-1-yl)-5-(2,3,5-trichlorophenyl)-pyrimidine (compound A) and its salts of acid addition, methods of their synthesis (variants) and pharmaceutical composition. The first method of synthesis of compound (A) or its salts involves interaction of compound of the formula (I)   where L is the group to be removed and Y is cyano-group with compound of the formula (II)   or its salt. Another method of synthesis involves interaction of compound of the formula (IV)   where Y is cyano-group and R 10  and R 11  are alkyl or in common they form the group -(C(R) 2 ) n  where R means hydrogen atom or alkyl and n = 2-4 with compound of the formula (II). Indicated compounds are able to inhibit glutamate release and can be used for treatment of patients with disorders of central nervous system, for example, for prophylaxis of cerebral ischemic damages. Pharmaceutical composition shows property of inhibitor of glutamate release and has the compound (A) as an active component or its pharmaceutically acceptable salt of acid addition and pharmaceutically acceptable carrier. Composition is made in the form for oral intake. EFFECT: new compound indicated above, improved method of synthesis, valuable medicinal properties. 18 cl, 1 tbl, 1 ex
There is limited high level research supporting the use of dry needling for mechanical shoulder pain. Dry needling is often used as an adjunct or primary treatment for musculoskeletal pain to address impairments related to muscle pain, range of motion (ROM), and strength deficits. This case study describes a 68-year-old female referred from her Physician to physical therapy (PT) with diagnosis of shoulder impingement syndrome. She underwent 12 sessions of traditional PT including manual therapy and therapeutic exercises with moderate pain reductions, improved ROM, and optimal functional outcomes using the Quick DASH. However, when progress was stalled, Dry needling (DN) was included in the plan of care. Dry needling was then performed as primary treatment to the anterior muscles of the shoulder (pectoralis major, pectoralis minor near the musculotendinous junction), and the latissimus, subscapularis and anterior deltoid) for two treatments resulting in significant improvements with ROM, reduced pain and improved functional outcomes which continued at 6-months with follow-up with patient.
Patients with high PD-L1 expression (CPS ≥ 20) will receive neoadjuvant immunotherapy alone. This treatment consists of serplulimab for 2 cycles.
Subjects will breathe Oxygen through a close fitting mask, but the flow will be low so that they rebreathe some of their expired air. After 30 seconds, the flow will be turned up so that they will breathe 100% Oxygen.
Contemporary pain models highlight cognitive-processing biases (ie, attention bias [AB], interpretation bias [IB], and memory bias [MB]) as key processes that contribute to poor pain outcomes. However, existing research has yielded inconsistent findings regarding the presence and impact of these biases on pain outcomes. Recognizing the need to explore these biases simultaneously, contemporary pain models suggest that cognitive biases (CBs) are interrelated, and may have a combined impact upon pain problems. The current study aims to investigate the interrelationships between CBs using the PainAIM paradigm, a novel approach enabling simultaneous evaluation of pain-related AB, IB, and MB using cues signaling actual pain rather than symbolic information. We hypothesized the presence and positive associations of biases for pain-related cues and the predictive value of combined AB and IB for poor pain outcomes. Eighty-four healthy participants completed the PainAIM paradigm, followed by a cold pressor task probing pain experience and pain-related task interference. The results indicated an inverse relationship between AB and IB for ambiguous pain cues. In addition, there was a positive association between participants' AB for ambiguous pain and their MB for the same cues. Contrary to our hypotheses, CB indices did not predict experimental pain outcomes. These findings provide support for the interrelationships between pain-related CBs. However, future research on the temporal order of CBs and their combined impact on pain outcomes is needed. By overcoming the limitations associated with traditional paradigms, the PainAIM paradigm offers a promising research tool for the further study of combined CBs in the context of pain. PERSPECTIVE: The current study provides insight into the associations between pain-related CBs (AB, IB, and MB) using ecologically valid (ambiguous) pain cues. The results indicated an inverse association between pain-related AB and IB, while a positive association was found between AB and MB. CBs did however not predict experimental pain outcomes.
Pulmonary embolism (PE) and deep vein thrombosis (DVT) are common postoperative complications. This study retrospectively analyzes preoperative attributes as risk factors for DVT or PE following primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). Preoperative transfusion, age 65+, dyspnea with moderate exertion, body mass index (BMI) 24.9+ were independent risk factors for PE following THA. Cardiac comorbidities were related with reduced risk. Bleeding disorder, operative time > 110 minutes, perioperative transfusion, age 65+, dyspnea at rest, and BMI < 18.5 were independent risk factors for DVT following THA. Perioperative transfusion, age 57+, dyspnea at rest and with moderate exertion, and BMI 24.9+ were independent risk factors for PE following TKA. Smoking status was related to reduced risk. Perioperative transfusion, age 65+, dyspnea with moderate exertion, and male sex were independent risk factors for DVT following TKA. Cardiac comorbidities were related with reduced risk. Identifying risk factors helps prevent DVT and PE after THA or TKA. (Journal of Surgical Orthopaedic Advances 33(3):138-142, 2024).
Fluorouracil injection is supplied in a pharmacy bulk package consisting of a vial. The pharmacy bulk package can be used to prepare doses for more than one patient. It is not supplied with a sterile transfer device, which is required for dispensing when multiple doses will be prepared from the single vial. The 50 mL and 100 mL vial is only intended for preparation in a Pharmacy Admixture Service under appropriate conditions for cytotoxic drugs [see References (15)]. Store vial at room temperature. They should be hung by the integral hanger provided and suspended as a unit in the vertical laminar flow hood. The container closure should be penetrated only one time utilizing a suitable sterile dispensing set or transfer device which allows measured distribution of the contents. Swab vial stopper with an antiseptic solution. Insert the device/set into the vial using aseptic technique. (see graphic illustration below.)  
  
Record the date and time the vial was opened on the vial label. Discard the pharmacy bulk package 4 hours after penetration of the container closure.

  
  


  


Once the sterile dispensing set or transfer device has been inserted into the container, withdrawal of the contents should be accomplished without delay.  
  
Withdraw the calculated dose for an individual patient into a sterile syringe. Inspect the solution in syringe for particulate matter and discoloration prior to administration or further dilution. Discard syringe if the solution contains particulate matter.
Most children with cerebral palsy (CP) can walk. Musculoskeletal disorders of these children cause deterioration in gait functions. Disruptions in gait limit children's participation. To minimize these impairments, various interventions are usually applied to children with CP who can walk. The ultimate goal of these interventions is to help these children achieve the best possible participation in activities of daily living. In addition, goal determination by children and families in treatment planning is important in terms of treatment success. The Gait Outcomes Assessment List (GOAL) is a scale developed to contribute to the determination of these goals. This questionnaire includes the priorities, expectations, and goals of children with CP who can walk and reveals their walking characteristics. The questionnaire is used in two languages, English and German, and there is no Turkish version of the questionnaire. Therefore, the aim of this study is to create the Turkish version of the 'Gait Outcomes Assessment List (GOAL)' family and child questionnaires and to examine its validity and reliability.