anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Head and neck cancer (HNC) is a prevalent and aggressive form of cancer with high mortality rates and significant implications for nutritional status. Accurate assessment of malnutrition in patients with HNC is crucial for optimizing treatment outcomes and improving survival rates. This study aimed to evaluate the use of ultrasound techniques for predicting nutritional status, malnutrition, and cancer outcomes in patients with HNC. A total of 494 patients with HNC were included in this cross-sectional observational study. Various tools and body composition measurements, including muscle mass and adipose tissue ultrasound evaluations, were implemented. Using regression models, we mainly found that high levels of RF-CSA (rectus femoris cross-sectional area) were associated with a decreased risk of malnutrition (as defined with GLIM criteria (OR = 0.81, 95% CI: 0.68-0.98); as defined with PG-SGA (OR = 0.78, 95% CI: 0.62-0.98)) and sarcopenia (OR = 0.64, 95% CI: 0.49-0.82) after being adjusted for age, sex, and BMI. To predict the importance of muscle mass ultrasound variables on the risk of mortality, a nomogram, a random forest, and decision tree models were conducted. RF-CSA was the most important variable under the random forest model. The obtained C-index for the nomogram was 0.704, and the Brier score was 16.8. With an RF-CSA < 2.7 (AUC of 0.653 (0.59-0.77)) as a split, the decision tree model classified up to 68% of patients as possessing a high probability of survival. According to the cut-off value of 2.7 cm2, patients with a low RF-CSA value lower than 2.7 cm2 had worse survival rates (p < 0.001). The findings of this study highlight the importance of implementing ultrasound tools, for accurate diagnoses and monitoring of malnutrition in patients with HNC. Adipose tissue ultrasound measurements were only weakly associated with malnutrition and not with sarcopenia, indicating that muscle mass is a more important indicator of overall health and nutritional status. These results have the potential to improve survival rates and quality of life by enabling early intervention and personalized nutritional management.
OBJECTIVE: To evaluate outcomes of robotic-assisted transplant ureteral repair (RATUR) for the management of kidney transplant ureteral strictures (TUS).
METHODS: We retrospectively analyzed 41 consecutive patients who underwent RATUR for TUS at multiple tertiary referral centers between January 2016 and December 2022. RATUR was performed utilizing a robotic-assisted transperitoneal approach. The primary outcome was stricture recurrence rate and secondary outcomes included postoperative complicate rate, determining factors impacting with allograft functional recovery, and rate of conversion to open surgery. Categorical and continuous variables are displayed as total number (Percentage) or median [Interquartile Range], respectively. Pearson correlation coefficient was utilized to assess categorical variable correlation with creatinine.
RESULTS: The median age was 56years [44,66]. The female-to-male ratio was 1.1:1. Approximately 66% of patients were dialysis-dependent prior to kidney transplantation. TUS was identified at a median time of 4months [2, 15.5] following kidney transplant. Median stricture length was 2 cm [1.22, 2.9 cm]. There were no TUS recurrences with a median follow-up of 36months [24,48]. There were 3 Clavien grade 2 and 1 Clavien grade 3 complications (9.5%). No baseline characteristics or preoperative diagnostics were correlated with a long-term decline in renal allograft function.
CONCLUSION: RATUR has excellent and durable outcomes with low complication rates. These findings encourage the use of a minimally invasive definitive repair as a first-line treatment option for the management of TUS.
Non-exercise activity thermogenesis (NEAT) is the energy expended engaging in daily activities such as maintenance of posture, fidgeting, and other activities not specifically designated as "exercise." A growing body of evidence indicates that NEAT plays an important role in overall energy balance; for example, differences in NEAT account for the ease with which adults gain or lose weight during over- or under feeding. An intriguing and possibly modifiable component of NEAT is fidgeting-like activity. In lean and overweight adults, modulation of NEAT by augmenting fidgeting can increase short-term energy expenditure. It is unknown whether NEAT can be altered in children, or whether augmenting NEAT in children can change daily energy expenditure or body composition long-term. Children exhibit higher levels of daily activity than adults, suggesting potentially profound differences in energy balance. We propose to study the role of NEAT in children to determine if: a) the fidgeting component of NEAT can be measured accurately and reproducibly in children; b) NEAT can be increased by devices that remind children to engage in fidgeting-like activities; and c) manipulation of fidgeting-NEAT can significantly change energy expenditure and body composition. Thirty lean and thirty overweight children will be enrolled and treated in a pilot feasibility study. By adapting technologies developed to measure activity in adults, children's behavior and thermogenesis will be recorded and analyzed to study question (a). To address study questions (b) and (c), we will ask children to wear a timer that vibrate on a fixed interval schedule and be randomly assigned to two conditions: the intervention or active condition, during which children will be cued by the timer to engage in a fidgeting behavior (rapidly moving their heel up and down), and the control condition, during which children will be asked to perform a less thermogenic activity (noting the cue). Children will then cross over so that each child will complete both conditions. Primary outcome measures for question (a) will be changes in energy expenditure when subjects are asked to fidget in a laboratory environment. The correlation of these energy expenditure measurements with new activity monitoring technologies will also be obtained, so that such equipment can be used for measurements under free-living conditions. For study questions (b) and (c), compliance with prescribed fidgeting regimens in a free living environment and the changes in energy expenditure and body composition will be determined over a 2 week interval. This pilot study will enable the determination of the sample size needed to assess the efficacy of a longer term NEAT intervention in children.
The local health insurance fund regularly offers people who have already had a free health check-up the opportunity to re-do a check-up. This invitation will be made as part of the routine, by mail. People who have participated in the MetACTIV study will be asked to participate in the present IRACTIV study ( they will be sent an information note). That way, up to 30 volunteers who previously participated in the MetACTIV study, including 10 for whom a particular profile has been identified will be recruited again in sequence.

On the day of consultation at the Gard health insurance fund, consent will be collected from subjects who have agreed to participate. The participation of the volunteers will be reduced to this single visit and 16 mL of blood will be collected on EDTA for the purpose of this study. As in the previous MetACTIV study, this blood will be transported to the Biological Resource Center at Nîmes University Hospital. From this blood, the plasma will be frozen and stored at -80°C for subsequent determination of insulin levels under the same conditions as for the MetACTIV study. Peripheral blood mononuclear cells will be frozen and, later, cultured at the Institute of Human Genetics in complete medium for 48 hours. The effect of the supernatants of these cultures on Akt phosphorylation in HepG2 cells exposed to 10nM of insulin will then be quantified by two different techniques (Western Blot and ELISA). This effect will be expressed as a percentage of inhibition compared to the phosphorylation of Akt induced by insulin alone. The insulin slope between the measurement performed in the MetACTIV study and this IRACTIV study will also be calculated and compared to the peripheral blood mononuclear cells ability to induce insulin resistance in vitro.
BACKGROUND: Proximal gastrectomy (PG) has become an increasingly preferred procedure for treating early cancer in the upper third of the stomach. However, advantages of PG in postoperative quality of life (QOL) over total gastrectomy (TG) has not fully proven.
METHODS: We conducted a multi-institutional prospective observational study (CCOG1602) of patients who undergo TG or PG for cStage I gastric cancer. We used the PGSAS-37 and EORTC-QLQ-C30 to evaluate the changes in body weight and QOL over a 3-year postoperative period. The primary endpoint was the weight loss rate 3 years after surgery.
RESULTS: We enrolled 109 patients from 18 institutions and selected 65 and 19 patients for inclusion in the TG and PG groups, respectively. Mean postoperative weight loss rates were 16.0% and 11.7% for the TG and PG groups, respectively (p = 0.056, Cohen's d 0.656) during postoperative year 1% and 15.0% and 10.8% for TG and PG (p = 0.068, Cohen's d 0.543), respectively, during postoperative year 3, indicating that the PG group achieved a better trend with a moderate effect size. According to the PGSAS-37, the PG group experienced a better trend in the indigestion subscale (p < 0.001, Cohen's d -1.085) and total symptom score (p = 0.050, Cohen's d -0.59) during postoperative year 3 compared with the TG group. In contrast, the EORTC-QLQ-C30 detected no difference between the groups at any time point during 3-year postoperative period.
CONCLUSIONS: This prospective study demonstrates that PG tended to be more favorable compared with TG with respect to postoperative weight loss and QOL, particularly regarding indigestion.
PURPOSE: A novel anti-sars virus drug containing xanthorrhizol is provided to enhance performance against SARS-CoV. CONSTITUTION: A novel anti-sars virus drug contains xanthorrhizol as an active ingredient. The xanthorrhizol is extracted from plant or is chemically synthesized. The pharmaceutically acceptable salt of xanthorrhizol is acid addition salt which is formed by using the organic acid or the inorganic acid. The food composition for preventing or improving SARS-CoV infections includes xanthorrhizol or the salt which is acceptable physiologically. The xanthorrhizol is extracted from plant or is chemically synthesized. An oral rinse composition for preventing or improving the SARS-CoV infections includes xanthorrhizol or the pharmaceutically acceptable salt as an active ingredient.
Each participant will undergo thermal pain threshold assessments ten times using the Medoc Pathway System with MRI-compatible ATS Thermode (30mmX30mm; Medoc Inc, Israel). Participants will be instructed to "focus on the thermal stimuli" for the first 5 trials, and to engage in three cognitive pain inhibition strategies (Attention/Distraction Strategy, Stimulus Quality/Severity Strategy, and the Control Strategy. The participants will be randomly assigned to receive Real Time fMRI Feedback of inverse activation in the PFC after each pain/rest block during the last 3 fMRI scans in the form of two simple thermometer images on the in-scanner computer display.
This training condition is designed to serve as an appropriate control condition for RIT, by providing no active ingredient of RI training components, while maintaining the overall training materials and structure similar. Similar to RIT, PLT uses the same task materials and a similar 40-level game structure. However, PLT will present simple RI-irrelevant visual judgment tasks to avoid changing RI-relate processes. The number of 45-min training sessions will be determined by their counterpart RIT participants through a yoked-control design.
The invention relates to a Bombina maxima host defensin peptide Boma-CATH and a gene and application thereof, belonging to the field of biomedicine. The host defensin peptide Boma-CATH is a polypeptide coded by a giant web bombesin defensin peptide gene of a special species of Chinese amphibian, has a molecular weight of 3124.38 daltons, an isoelectric point of 5.2, and an amino acid sequence shown as SEQ ID NO. 1. The gene (GenBank accession No. OR797636) for encoding the precursor of Bombina maxima Boma-CATH consists of 690 nucleotide sequences, the nucleotide sequence of which is shown in SEQ ID NO. 2, wherein the 430 th to 510 th nucleotides are the encoding genes for mature Bombina maxima host defensin peptide Boma-CATH. The Bombina maxima host defensin peptide Boma-CATH can be used for preparing medicines for treating skin tumor including malignant melanoma and skin squamous cell carcinoma.
Given the risks associated with poor adherence and the apparent contribution of good adherence to reducing hospitalizations and emergency department (ED) visits, interventions for promoting good adherence should be pursued. To this end, a number of devices have been developed to promote medication adherence, though with limited success due to reliability, cost, etc. The purpose of this study is to investigate the efficacy of the Karie Automated Medication Delivery Device in enhancing medication adherence among a group of community-dwelling patients immediately following discharge from inpatient rehabilitation.

This study will utilize a multi-site randomized controlled trial design. One week prior to discharge from inpatient rehab, consenting patients will be randomly assigned to receive medication self-management education only (SME) or medication self-management education + Karie (SME+K). Both sites (West Park Healthcare Centre, and CapitalCare) will recruit 150 participants for the study. At each site, 75 patients will be in the intervention group (SME + Karie) and 75 will be in the control group (SME only).
<P>PROBLEM TO BE SOLVED: To provide a labeling substance to effectively detect a double-stranded helical structure of a nucleic acid.  <P>SOLUTION: The nucleoside compound and a phosphoroamidite derivative thereof have a spacer of a peptide structure or a peptoid structure capable of reacting with a labeling compound in a nucleic acid base thereof. The phosphoroamidite derivative is introduced in the nucleic acid by the phosphoroamidite method and then the nucleic acid labeled by the reaction with the labeling compound is synthesized. The labeled nucleic acid can be used as the labeling substance to effectively detect a double-stranded helical structure of a nucleic acid. The labeling substance can be used in broad applications such as research, clinic, diagnosis, in vitro gene detection and in vivo gene detection, because of its excellent detection sensitivity of a nucleic acid, and the like.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Patient will receive propofol 0.3-4 mg/kg/h. Patients will be randomized to receive propofol intravenously at rates of 0.2-1.4 μg/kg/h and 0.3-4 mg/kg/h for 2 days, respectively, to maintain the Richmond Agitation-Sedation Scale (RASS) within the range of +1 to -2.
The present application discloses compositions and methods of synthesis a nd use of F-18 labeled molecules of use, for example, in PET imaging techniq ues. In particular embodiments, the labeled molecules may be peptides or pro teins, although other types of molecules including but not limited to aptame rs, oligonucleotides and nucleic acids may be labeled and utilized for such imaging studies. In preferred embodiments, the F-18 label may be conjugated to a targeting molecule by formation of a metal complex and binding of the F -18-metal complex to a chelating moiety, such as DOTA, NOTA, DTPA, TETA or N ETA. In other embodiments, the metal may first be conjugated to the chelatin g group and subsequently the F-18 bound to the metal. In other preferred emb odiments, the F-18 labeled moiety may comprise a targetable conjugate that m ay be used in combination with a bispecific or multispecific antibody to tar get the F-18 to an antigen expressed on a cell or tissue associated with a d isease, medical condition, or pathogen. Exemplary results show that F-18 lab eled targetable conjugate peptides are stable in human serum at 37°C for sev eral hours, sufficient time to perform PET imaging analysis.
There is limited data relating head impact biomechanics to neurological outcomes in humans. Concussion occurs from rotational loading of the head giving rise to diffuse stresses and strains in the brain tissue leading to autonomic and physiological dysfunction. Repeated head loading is common in contact sports and an integral part of soccer. It is unknown whether the same biomechanical forces from lower severity head impacts such as typical soccer heading cause temporary physiological deficits as well. Advancement of objective physiological function assessment devices allow measurement of neurological effects in the absence of diagnosed concussion. Recent soccer heading studies have evaluated neurophysiological changes pre- and post-repetitive heading. These studies have found conflicting results for the effect on neurocognitive performance immediately following a bout of heading, but consistent changes were observed in measures of vestibular balance, ocular function, and neurochemical biomarkers.

Soccer heading biomechanics studies showed that females experienced higher severity head loading, and in equivalent sports such as soccer and basketball, females have higher concussion rates. This study will compare the physiological changes of male and female adolescents completing one of two soccer heading paradigms to those randomized to kicking to evaluate the effect of repetitive head impacts. This study will relate biomechanical measures of head loading with physiological function changes associated with repeated head impacts, and compare sex-differences in biomechanical measures and physiological changes.
Single-chain fragment variable (scFv) antibody fragment (I), directed against melanoma-associated chondroitin sulfate proteoglycan (MCSP), with variable domains in an orientation of heavy chain variable domain-linker-light chain variable domain (VH-linker-VL), is new, where the VH domain comprises amino acid sequences of SEQ ID NO. 1 (comprising a fully defined 121 amino acid sequence, as given in the specification) or SEQ ID NO. 2 (comprising a fully defined 121 amino acid sequence, as given in the specification) and the linker is a covalent bond or an oligopeptide. Single-chain fragment variable (scFv) antibody fragment (I), directed against melanoma-associated chondroitin sulfate proteoglycan (MCSP), with variable domains in an orientation of heavy chain variable domain-linker-light chain variable domain (VH-linker-VL), is new, where the VH domain comprises amino acid sequences of SEQ ID NO. 1 (comprising a fully defined 121 amino acid sequence, as given in the specification) or SEQ ID NO. 2 (comprising a fully defined 121 amino acid sequence, as given in the specification), the VL domain comprises amino acid sequences of SEQ ID NO. 3 (comprising a fully defined 112 amino acid sequence, as given in the specification) or SEQ ID NO. 4 (comprising a fully defined 112 amino acid sequence, as given in the specification) or corresponding sequences exhibiting one or more point mutations, and the linker is a covalent bond or an oligopeptide. Independent claims are included for: (1) a fusion protein comprising (i) a domain with (I) and (ii) at least a domain with a functional protein- or peptide sequence that is covalently linked with the domain (i); (2) nucleic acid sequences for (I) or the fusion protein; (3) a vector comprising the nucleic acid sequences; and (4) a cell comprising (I), fusion protein, the vector and/or the nucleic acid sequences. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.
The invention relates to a navel paste for treating night sweat, spontaneous sweating, enuresis, and lax and a preparation method thereof. The navel paste is prepared by the following raw materials according to parts by weight: 8-12 g of nutgall, 8-12 g of milk veteh, 1-2 g of cinnamon, and 1-2 g of costustoot. The preparation method of the navel paste comprises the steps that: the nutgall is ground; the volatile of the cinnamon and the costustoot is extracted; the milk veteh is extracted by decocting; finished products are compounded, and the like. The navel paste has the advantages of choice of drugs scouring, a medicine multi-purpose, executing astringing and supplementing, reasonable compatibility of medicine, assistant and guide, and suitable primary and secondary. The preparation method causes that the navel paste is refined in a larger level; that is to say the volume of the navel paste is reduced and the content of active ingredient in unit volume is increased, thus guaranteeing curative effect. By clinical observation, the navel paste has obvious curative effect in treating lax, enuresis, and sweating, thus proving the rationality of the prescriptions of the preparation and the preparation method. Meanwhile, the preparation is characterized by convenient use without any side effect and is especially suitable for the situation of difficult coordination on taking medicine and keeping taking medicine over a long time for infants.
Real time, remote access to and adjustment of the hearing aid of a patient while the patient is located in a normal life environment that is remote from a hearing professional. A session request initiates a programming session. Adjustable settings from the patient's hearing aid are wirelessly streamed to the patient's mobile device and from the mobile device to a streaming cloud server. The settings are stored on the cloud, streamed from the cloud to a hearing professional's computer or mobile device and displayed. The hearing professional then changes at least one of the adjustable hearing aid settings and the changed settings are streamed to the cloud, stored on the cloud, streamed from the cloud to the patient's mobile device, wirelessly transmitted to the hearing aid and stored there. A telephonic voice connection between the hearing professional and the patient's mobile device is used to transmit the patient's evaluation of changed settings to the hearing professional.
A system and method enhance the workflow of an electrophysiologist. A workstation may be interconnected with a number of medical devices associated with an EP lab. A user may enter patient registration data using the workstation that is subsequently sent to the medical devices. The medical devices may each perform a different electrophysiology related function and generate electrophysiology related data. The medical devices may send the data generated to the workstation. The workstation may perform operations on the data received to provide integrated results. The integrated results may include updating previously stored patient data and images or combining the data received to provide more detailed information and/or enhanced images. The integrated results may include displaying images and data from a number of medical devices on a display screen simultaneously. The workstation may generate a unified patient report based upon the data received from the medical devices.