anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Keratoconus (KC) is a degenerative disorder resulting from the degradation of the stromal collagen fibril network in the cornea, leading to its thinning and conical deformation. Various studies have established animal models of KC by using the collagenase type II enzyme to gain a better understanding of the pathogenesis, however, long-term monitoring or follow-up of the models have not been reported so far. This study evaluates the long-term stability of collagenase type II-induced KC in a rabbit model. Six New Zealand rabbits were divided into 4 study groups with 3 eyes per group. The groups were control (group 1), 0.5% proparacaine + 5 min collagenase treatment on day 0 and day 30 (group 2), 0.5% proparacaine + 10 min collagenase treatment on day 0 (group 3) and, mechanical debridement + 2 min collagenase treatment on day 0 (group 4). Inflammation was observed in group 4 till week 10. Significant decrease in the central corneal thickness was observed in group 3 by week 4 (p < 0.001) however, the thickness was regained in the subsequent follow-ups in all the groups. Keratography results showed no changes in Km values but an increased astigmatic power in all groups. Scanning electron microscopy images revealed thinner collagen fibrils arranged in a mesh-like pattern above the uniform layer of the collagen lamellae in the central part of the treated corneas. Similarly, histological staining revealed loosely packed stromal fibrils in the anterior portion of the cornea which corroborates with the immunofluorescent staining results. This study revealed the remodeling of the corneal structure by eight weeks of collagenase treatment. Consequently, the possibility of creating a rabbit keratoconus model induced by collagenase may warrant further consideration.
Herpes simplex virus type 2 (HSV-2) is highly prevalent in several regions of the world and is the main pathogen causing genital herpes, which is transmitted almost exclusively through sexual contact. Systemically disseminated infections caused by HSV-2 are rare and most often seen in newborns, pregnant women, or immunocompromised populations. The virus can invade multiple organs and cause damage. In this paper, we present an extremely rare case of an immunocompetent 36-year-old male who came to our hospital with a high fever with abdominal pain and died of sepsis and multiple organ dysfunction syndrome within a short period. After the exclusion of common pathogens such as bacterial and fungal infections during hospitalization, metagenomic next generation sequencing of the patient's peripheral blood and ascites gave us the answer, and very high nucleic acid sequence counts of HSV-2 were detected in both his peripheral blood and ascites, confirming HSV-2 as the causative virus. In addition, this paper provides a brief review of the relevant literature.
Cervical radiculopathy is a distinct consideration in the evaluation of any patients who have neck pain and may be defined simply as an abnormality of a nerve root which originates in the cervical spine. The initial approach to the management of cervical spondylopathic radiculopathy is nearly the same as that of nonspecific neck or back pain that can be found in most patients. Conservative treatments include non-steroidal anti-inflammatory drugs (NSAIDs), narcotics, muscle relaxants, physical therapy and transcutaneous electrical nerve stimulation (TENS). The main objectives of conservative treatments are to relieve pain, improve function and improve health-related quality of life. However, these treatments for cervical radiculopathy are limited by their modest effectiveness. Surgical treatment for cervical disc disease is indicated when symptoms are refractory to conservative treatments and neurological symptoms are progressive. In terms of pharmacotherapy, there is generally no randomized, placebo-controlled trial available comparing standard nonsurgical treatment. Therefore, care plans should be designed principally based on accumulated experience, the services available locally, and the respective preferences of patients. Treatment plans are developed to alleviate pain, improve function, and prevent recurrences.

As a complementary and alternative medicine (CAM), herbal medicines have the potential to avoid the adverse effects of medications and surgery.According to the basic theory of traditional Chinese medicine (TCM), the obstruction of Qi flow and blood circulation in the neck area caused by pathogenic factors, such as "Feng"(wind), "Han"(cold), "Shi"(dampness), invading the neck induces cervical degenerative disc diseases which are the cause of cervical radiculopathy. According to the four traditional methods of diagnosis -observation, listening, interrogation, and pulse-taking, TCM doctors can analyze the specific pathogenic factors which cause neck pain. Accordingly they can then prescribe herbal formulae based on the effect and the main indications according to the principles of Chinese medicine. Natural substances, including herbal medicines, have been used to promote healing and alleviate neck pain in western countries. Previous studies have demonstrated that some active substances in herbal medicine can promote Qi flow and blood circulation to alleviate pain.
<P>PROBLEM TO BE SOLVED: To provide fermented black garlic extract liquid and fermented black garlic powder each as a fermented black garlic processed product obtained by subjecting raw garlic to self-fermentation, causing no garlic smell on expiration after eaten, and excellent in bioactivation: to provide a method for producing the processed products: and to provide food and drink containing the liquid or the powder.  <P>SOLUTION: The fermented black garlic extract liquid comprises fermented black garlic extract obtained by causing self-fermentation on raw garlic. The fermented black garlic powder comprises dried and pulverized fermented black garlic obtained by subjecting raw garlic to self-fermentation. The products comprising the fermented black garlic extract liquid or the fermented black garlic powder are obtained by aging the raw black garlic at 55-80°C in a humidity of 70-95% to subject the raw black garlic to self-fermentation. The method for producing the fermented black garlic extract liquid and the fermented black garlic powder each comprises a process of subjecting raw garlic to self-fermentation, a process of forming the obtained fermented black garlic into pasty one, a process of extracting the pasty fermented black garlic and a process of condensing the extract.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Patients will receive five visits with a CHW during a 6 month period (two in-person and three by telephone). At the first visit, patients will meet the CHW who is trained in motivational interviewing techniques to deliver coaching to work on behavioral changes and introduce a 60 minute Digital Video Disc of five patient stories of individuals who have managed to control their hypertension.
A solid water particle composition and method of use enhances the efficacy of a cosmetic item, a consumable liquid, and an organic liquid. The composition is based on a solid water particle phase of water. The composition consists of adding solid water particle composition to cosmetic item and a consumable liquid with or without replacing the pure water in the cosmetic item and consumable liquid, while at least one indigenous ingredient in the cosmetic item and consumable liquid remains substantially the same. The cosmetic item includes a cosmetic face mask and a cosmetic face cream. The consumable liquid includes an herbal drink. The solid water particle composition can also replace pure water in an organic liquid, such as alcoholic drink, organic solvent, liquid fuel, and paint. The cosmetic items and consumable liquids are enhanced by replacing pure water, with water having solid water particles and leaving ingredients substantially the same.
FIELD: virology, biotechnology. SUBSTANCE: invention relates to preparing a recombinant ALFA-2-interferon-base lyophilized preparation where serum component containing antibodies to one or some pathogens of viral diseases is added. Immune sera or immunoglobulins taken at final concentrations 0.5-10.0% by total protein can be used as a serum component. Method can be used for preparing curative-prophylaxis immune biological preparations showing antiviral effect. EFFECT: enhanced antiviral activity, increased stability at storage. 2 cl, 3 tbl
PCT No. PCT/JP98/01741 Sec. 371 Date Dec. 16, 1998 Sec. 102(e) Date Dec. 16, 1998 PCT Filed Apr. 16, 1998 PCT Pub. No. WO98/46089 PCT Pub. Date Oct. 22, 1998In accordance with the present invention, it is provided a method for producing a yeast extract with the improvement in the color and odor characteristic to yeast extract and with no modification of the useful substances such as amino acid, etc. compared with conventional yeast extract. By a simple method in accordance with the present invention, color and characteristic odor can be removed, with almost no loss of the contents of useful substances such as amino acid, etc. from the yeast extract solution produced in a conventional manner. Because the resulting yeast extract can be mixed with other materials for use, the yeast extract is applicable to various fields, for example for cosmetic products and healthy foods other than seasonings, which expectantly enlarges the applicable range of the yeast extract.
The Study design will be randomized clinical trial. This study will be conducted in Pakistan Sports Board, Lahore. The study will be completed within duration of 10 months after the approval of synopsis. Sample size will be thirty tennis players. Non-probability Convenient sampling will be used to recruit the individuals for the study and then the randomization will be done by lottery method to divide the individuals into two strengthening exercise group. One group is given Plyometric strengthening exercise plan for 5 weeks along with Tennis specific training and on the other hand isotonic strengthening exercise plan for 5 weeks with Tennis specific training and after that their pre and post values will be measured on SPSS version 25. The objective of this study is to Determine Comparative Effects of Plyometric and Isotonic Strengthening Exercises on Speed, Agility and balance of lower extremity among field Tennis Players To move around the court swiftly and effectively, tennis players need to be very agile and balanced. Plyometric exercises can help tennis players develop explosive power and speed. Rapid muscle contractions during plyometric exercises can help with acceleration, power, and reaction time. Tennis players can benefit from plyometric exercises like jump squats, box jumps, and medicine ball throws. Tennis players can enhance their range of motion and lower their risk of injury by engaging in flexibility exercises. Yoga, Pilates, and stretching routines can increase flexibility and assist athletes keep their balance and posture while playing For tennis players, isotonic exercises are a crucial part of a successful fitness regimen. Exercises that are isotonic can increase muscle strength and endurance, which is important for generating power in shots and keeping proper posture on the court. Bicep curls, triceps extensions, and lunges are a few isotonic exercises for tennis players. Tennis players must also engage in plyometric exercises because they can enhance their explosive power and quickness. Rapid muscle contractions during plyometric exercises can help with acceleration, power, and reaction time. Tennis players can benefit from plyometric exercises like jump squats, box jumps, and medicine ball throws Tennis players can potentially lower their risk of injury by engaging in isotonic activities. Isotonic workouts can lower the incidence of common tennis injuries like shoulder, knee, and ankle sprains by enhancing muscle strength and joint stability.

Tennis players might benefit from plyometric training to increase their balance and agility. Plyometric exercises feature quick changes in direction and rapid movements, which can help players move more quickly and effectively around the court.

Tennis players that incorporate isotonic and plyometric workouts into their training regimen can enhance their overall performance. Tennis players may hit the ball harder, move around the court more quickly, and enhance their overall performance by developing their strength, power, speed, and agility
Self-awareness is markedly impaired in severe mental illness including schizophrenia and schizoaffective disorder. This impairment spans awareness of symptoms as well as deficits in the estimation of abilities and capabilities, which we refer to as introspective accuracy (IA). Recent work has provided evidence of IA deficits in schizophrenia spectrum disorders, specifically in the abilities to retrospectively judge everyday functioning and neurocognitive impairment, as well as the ability to make correct real-time judgments of performance on neurocognitive tests.

Transcranial Direct Current Stimulation (tDCS) is a form of noninvasive neurostimulation which has been proposed as a therapeutic procedure in numerous psychiatric disorders. TDCS in healthy adults has been demonstrated to improve cognitive and memory performance, and in schizophrenia, tDCS has been found to improve emotion recognition ability. TDCS thus appears to be a promising therapeutic technique that may be useful for improving IA. This study will compare IA performance in individuals with schizophrenia across two conditions: active anodal tDCS and sham tDCS.
The invention discloses a Chinese medicinal composition for treating hemorrhagic pneumonia of minks, belonging to the field of Chinese medicaments. The composition consists of momordica grosvenori, oyster powder, loquat leaves, lonicera stems and pear peel. The granularity of the momordica grosvenori, the oyster powder, the loquat leaves, the lonicera stems and the pear peel is 20-200 meshes. The composition has the treatment principle of moistening lung to arrest cough and eliminating phlegm and dampness, the formula is reasonable, the preparation process is simple; the adopted Chinese medicinal herbs are wide in source and low in cost, and the medicament does not have residues or toxic or side effect and is easily absorbed by animals. The composition has significant effects of moistening lung to arrest cough, eliminating phlegm and dampness and regulating body functions, effectively treats the hemorrhagic pneumonia of the minks, and shortens the convalescence. When being applied, 0.5g of medicament is decocted and taken by per kilogram of mink, and clinical trials prove that the cure rate reaches over 90% and the medicament has a unique treatment effect.
The DNA damage response is essential for preserving genome integrity and eliminating damaged cells. Although cellular metabolism plays a central role in cell fate decision between proliferation, survival, or death, the metabolic response to DNA damage remains largely obscure. Here, this work shows that DNA damage induces fatty acid oxidation (FAO), which is required for DNA damage-induced cell death. Mechanistically, FAO induction increases cellular acetyl-CoA levels and promotes N-alpha-acetylation of caspase-2, leading to cell death. Whereas chemotherapy increases FAO related genes through peroxisome proliferator-activated receptor α (PPARα), accelerated hypoxia-inducible factor-1α stabilization by tumor cells in obese mice impedes the upregulation of FAO, which contributes to its chemoresistance. Finally, this work finds that improving FAO by PPARα activation ameliorates obesity-driven chemoresistance and enhances the outcomes of chemotherapy in obese mice. These findings reveal the shift toward FAO induction is an important metabolic response to DNA damage and may provide effective therapeutic strategies for cancer patients with obesity.
A method for treating a disease caused by protein retention in the endoplasmic reticulum (ER) with a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is surface-modified such that it is targeted to the ER. The inhibitor reduces protein retention in the ER and the encapsulation lowers side effects of the inhibitor, e.g., cytotoxicity, as compared to administering the inhibitor without encapsulation. Also disclosed is a pharmaceutical composition that can be used for carrying out the method. Further provided is a transgenic mouse carrying in its genome a heterologous nucleic acid that encodes an H338Y mutant gp91 phox  protein. The transgenic mouse can serve as a model for human chronic granulomatous disease.
PURPOSE:To provide the dialysis pharmaceutical having excellent stability and water solubility by laminating a layer contg. org. acids and a layer contg. bicarbonate via an intermediate layer held therebetween, thereby preparing the laminated pharmaceutical contg. the electrolyte necessary for preparing a dialyzate and the pharmacologically permitted org. acids. CONSTITUTION:This dialysis pharmaceutical is formed as the laminated pharmaceutical contg. the electrolyte necessary for preparing the dialyzate contg. at least Na<+>, Ca<++>, Cl<-> and HCO3<-> and the pharmacologically permitted org. acids. Namely, the pharmaceutical is formed by laminating the inside layer contg. a core material (nucleus) and the org. acids without contg. the bicarbonate, the outside layer contg. the bicarbonate without contg. the org. acids and the intermediate layer to be interposed between the inside and outside layers. One or >=2 kinds selected from a group consisting of citric acid, tartaric acid, maleic acid, oxaloacetic acid, isocitric acid and malic acid are used as the solid org. acids. As a result, the dialysis pharmaceutical which has the excellent stability and dissolves rapidly in water at the time of use is provided.
Tenofovir is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of VIREAD [See Adverse Reactions (6.2)].

It is recommended that creatinine clearance be calculated in all patients prior to initiating therapy and as clinically appropriate during therapy with VIREAD. Routine monitoring of calculated creatinine clearance and serum phosphorus should be performed in patients at risk for renal impairment.

Dosing interval adjustment of VIREAD and close monitoring of renal function are recommended in all patients with creatinine clearance <50 mL/min [See Dosage and Administration (2.2)]. No safety or efficacy data are available in patients with renal impairment who received VIREAD using these dosing guidelines, so the potential benefit of VIREAD therapy should be assessed against the potential risk of renal toxicity.

VIREAD should be avoided with concurrent or recent use of a nephrotoxic agent.
Disclosed is a graph neural network-based disease diagnosis and prediction system, the system comprising a knowledge graph construction module, a data extraction and preprocessing module, a disease diagnosis model construction module, and a disease diagnosis model application module. According to the present invention, expert knowledge and electronic medical record data are effectively integrated in a knowledge graph, to construct a heterogeneous graph network. On the heterogeneous graph network, local information and global information of the heterogeneous graph network are learned using a graph convolutional neural network method. A disease diagnosis model can perform end-to-end training on both knowledge and data. In a model optimization target, in addition to optimizing a disease prediction task, supervision information on knowledge relationships is also added to ensure that a disease prediction task can effectively utilize the knowledge, and that knowledge representation is not affected by data noise. For the problem of a large number of predicted diseases and a limited number of corresponding patients for some diseases, multi-label hierarchical classification is designed, to improve the prediction effect for diseases having few sample categories.
Particles and methods for the detection or visualization of analytes, including nucleic acids, using fluorescence energy transfer or intramolecular energy transfer. Particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stockes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein , polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles. Many novel phthalocyanine derivatives and hybrid phthalocyanine derivatives are disclosed and claimed. Such derivatives also may contain an electron transfer subunit. Axial ligands may be covalently bound to the metals contained in the hybrid phthalocyanine derivatives. Numerous compounds capable of intramolecular energy transfer as well as compounds for fluorescence energy transfer are claimed.
To provide porous materials that contain the active ingredient for a long period of time and are advantageous from the viewpoint of releasing the active ingredient at a desired timing.SOLUTION: A porous material 10 has a porous structure 11. The porous material contains regenerated cellulose and an active ingredient 12. The regenerated cellulose is present in a porous structure. The active ingredient is an active ingredient for the living body and is in contact with the porous structure. The porous material has a thickness of 100 nm or more and 250 μm or less. The porous structure has an elastic modulus of 1 GPa or less. The volume of pores having a pore diameter of 100 nm or less in the porous structure is 0.5 cm3/g or more. The specific surface area of the pores having a pore diameter of 100 nm or less in the porous structure is 10 m2/g or more. The content of the active ingredient in the porous material is 30% or more on a weight basis.SELECTED DRAWING: Figure 1
FIELD: medicine. ^ SUBSTANCE: claimed technical solution relates to field of producing medications from vegetable raw materials. Extraction of birch mushroom polypore with water at increased temperature in two stages, separation of extracts, their combination with further drying. Extraction is carried out in electric field of constant current in electrolyser with insoluble electrodes with constant current density in the range from 7 to 40 A/m2 at temperature 50-70C with weight ratio polypore : water equal 1:6-8 for 40-60 minutes at each stage. ^ EFFECT: invention allows to reduce time of carrying out the process and energy consumption. ^ 8 ex, 1 tbl