anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Eligible patients scheduled for neurosurgeries were enrolled into either a standard care group (Control Group) or an intervention group (SpHb Group). The Control Group received typical anesthesia care including estimated blood loss (EBL) assessment and intraoperative hemoglobin measurements from the central laboratory (Hb). Blood samples were taken when EBL was ≥15% of total blood volume. RBC transfusion was initiated if Hb was ≤10 g/dL and continued until the EBL was replaced and Hb \>10g/dL was confirmed. The SpHb Group followed the same transfusion practice as the Control Group except the anesthesiologist was guided by the addition of SpHb monitoring with blood samples still taken pre- and post-transfusion. Additionally, the absolute and trend accuracy of SpHb compared to Hb was evaluated. Potential cost savings from reduced RBC utilization will be calculated if occured.
Liver transplantation is one of the most effective treatments for acute liver failure, cirrhosis, and even liver cancer. The prediction of postoperative complications is of great significance for liver transplantation. However, the existing prediction methods based on traditional machine learning are often unavailable or unreliable due to the insufficient amount of real liver transplantation data. Therefore, we propose a new framework to increase the accuracy of computer-aided diagnosis of complications after liver transplantation with transfer learning, which can handle small-scale but high-dimensional data problems. Furthermore, since data samples are often high dimensional in the real world, capturing key features that influence postoperative complications can help make the correct diagnosis for patients. So, we also introduce the SHapley Additive exPlanation (SHAP) method into our framework for exploring the key features of postoperative complications. We used data obtained from 425 patients with 456 features in our experiments. Experimental results show that our approach outperforms all compared baseline methods in predicting postoperative complications. In our work, the average precision, the mean recall, and the mean F1 score reach 91.22%, 91.70%, and 91.18%, respectively.
This disclosure provides the first description of hESC-derived cells transplanted into human patients. Results are reported for one patient with each of Stargardt's Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD). Controlled hESC differentiation resulted in near-100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. The hESC-derived RPE cells have shown no signs of rejection or tumorigenicity at the time of this report. Visual measurements suggest improvement in both patients.
Rheumatoid arthritis (RA) is the most prevalent chronic autoimmune inflammatory rheumatism. Its pathophysiology is largely dependent on TNF. Severe RA as well as several other inflammatory and autoimmune diseases are treated with TNF inhibitors (TNFi). However, to date only 30-50% achieve low disease activity or remission with this treatment regimen and some patients experience secondary non-response or relapse. Herein, the inventors evaluated by RT-qPCR the mRNA expression of CD36, which was already described to be regulated by TNFi 5 , some specific NRF2 target genes (FBX030, GABARA, LBR, MAFG, OSGIN1, HMOX1), which play a role in the anti-oxidative stress response or anti-inflammatory pathway, and the expression of CSMD1, an anti-inflammatory gene that we observed as up-regulated by all TNFi. Interestingly, they observed 2 different subsets of healthy donors: (i) donors in which TNFi stimulation increased mRNA of target genes in macrophages and (ii) conversely donors with no significant upregulation in transcription of these target genes. Then they classified donors two different status, “activators” or “non-activators” of tmTNF reverse signaling after TNFi stimulation, which correlates to clinically responder and non-responders to TNFi. Thus, based on all these observations, they developed an in vitro method for predicting the response to TNF inhibitors in patient in need thereof.
BACKGROUND: There is no specific treatment for sudden cardiac arrest (SCA) manifesting as pulseless electric activity (PEA) and survival rates are low; unlike ventricular fibrillation (VF), which is treatable by defibrillation. Development of novel treatments requires fundamental clinical studies, but access to the true initial rhythm has been a limiting factor.
METHODS: Using demographics and detailed clinical variables, we trained and tested an AI model (extreme gradient boosting) to differentiate PEA-SCA versus VF-SCA in a novel setting that provided the true initial rhythm. A subgroup of SCAs are witnessed by emergency medical services personnel, and because the response time is zero, the true SCA initial rhythm is recorded. The internal cohort consisted of 421 emergency medical services-witnessed out-of-hospital SCAs with PEA or VF as the initial rhythm in the Portland, Oregon metropolitan area. External validation was performed in 220 emergency medical services-witnessed SCAs from Ventura, CA.
RESULTS: In the internal cohort, the artificial intelligence model achieved an area under the receiver operating characteristic curve of 0.68 (95% CI, 0.61-0.76). Model performance was similar in the external cohort, achieving an area under the receiver operating characteristic curve of 0.72 (95% CI, 0.59-0.84). Anemia, older age, increased weight, and dyspnea as a warning symptom were the most important features of PEA-SCA; younger age, chest pain as a warning symptom and established coronary artery disease were important features associated with VF.
CONCLUSIONS: The artificial intelligence model identified novel features of PEA-SCA, differentiated from VF-SCA and was successfully replicated in an external cohort. These findings enhance the mechanistic understanding of PEA-SCA with potential implications for developing novel management strategies.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of urea of the general formula (I)   where R 1  means hydrogen atom or lower alkyl; R 2  means hydrogen or halogen atom; R 3  means hydrogen atom or lower alkoxy-group and to their physiologically compatible acid-additive salts. Invention describes also method of synthesis of compounds in two variants and medicinal agent. Derivatives of urea exhibit antagonistic properties with respect to neurokinin receptors and pattern of effect that is favorable for treatment of functional and inflammatory disorders of gastroenteric tract in higher mammals. EFFECT: improved methods of synthesis, valuable medicinal properties. 5 cl, 3 tbl
Monotherapy CID-103. Priming dose will be given for first dose. Dose and duration of infusion dependent on dose cohort and tolerability.
OBJECTIVE: Occupational exposures may be associated with reproductive health and pregnancy outcomes. This study investigated the association between occupational exposures and reproductive health, pregnancy outcomes, and the lactation period among hospital staff.
MATERIALS AND METHODS: Seven hundred thirty-three female healthcare workers from hospitals affiliated with the Tehran University of Medical Sciences were invited to participate in this cross-sectional study. The measurement method for fertility consequences was self-report. Demographic characteristics, occupational data, medical history, and reproductive history were collected via data collection form. Finally, reproductive outcomes were evaluated in different occupational hazard categories.
RESULT: Chemical exposures (solvents) were a risk factor for stillbirth. Prolonged working hours were associated with spontaneous abortion and breastfeeding periods. Shift workers did not have a higher frequency of reproductive and pregnancy outcomes, but the breastfeeding period was significantly decreased in shift workers. Psychiatric disorders were associated with preterm labour, low birth weight, and stillbirth in sequence with nervousness, depression, and mood disturbance. Furthermore, depression affects the breastfeeding period. Moreover, we found a link between job titles and infertility. In addition, socioeconomic status was related to stillbirth and infertility.
CONCLUSION: The study revealed that chemical and ergonomic exposures have associations with some reproductive outcomes. We also conclude that shift work could adversely affect the breastfeeding period. So, implementing some organizational strategies to control adverse health effects of occupational hazards and modifying shift work and working hours for nursing mothers is recommended.
BACKGROUND: Achilles tendon ruptures that are older than 4-6 weeks or developed over a more extended period are chronic. Two challenges characterize the treatment. First, defect zones over a length of several centimeters must frequently be bridged. Second, a prolonged loss of function of the muscles leads to an irreversible fatty degeneration of the tissue. So that even if the tendon is restored, significant functional deficits remain. If there are doubts about the ability of the calf muscles to regenerate, regardless of the size of the defect, tendon transfers are recommended to use the power of an additional muscle to support the plantar flexion of the ankle.
TREATMENT: Established concepts are the transposition of the flexor hallucis longus or the peroneus brevis muscle. If the muscle is intact, defects of up to 2 cm can be treated with a direct suture. Defects between 2 and 5 cm can be bridged using a VY-plasty or a turndown flap. For larger defects, free tendon transplants can be considered. The technical alternative for larger defects is a tendon transfer of the flexor hallucis longus or the peroneus brevis muscle. Besides bridging the defect, another advantage of tendon transfer is that vital muscle tissue is placed in the bed of the Achilles tendon. Both tendons are covered with muscle tissue over nearly the full length, which offers advantages, especially in patients with critical soft tissue or after infection.
FOLLOW-UP TREATMENT AND PROGNOSIS: Follow-up treatment is analogous to an acute Achilles tendon rupture. However, permanent impairments are possible; 75-80% of athletes regain their original performance level.
PROBLEM TO BE SOLVED: To obtain a physiologically active extract which exhibits various physiological effects, e.g. antimicrobial effect, antiviral effect, antitumor effect, and the like, on the mammals containing human beings, shows no toxicity and is useful for foods, cosmetics and medicines by extracting an ethyl acetate- soluble component from fresh Polygonum tinctorium. SOLUTION: This physiologically active extract is prepared by immersing fresh Polygonum tinctorium in an organic solvent (e.g. methanol, ethyl acetate, or the like) to extract an ethyl acetate-soluble component and collecting the component. It is favorable that the fresh Polygonum tinctorium is collected prior to fructification and a part or the whole of the fresh terrestrial part is washed with water, immersed in an organic solvent of a 1-100 fold amount in volume and extracted for 0.1-100 hr under warming. Although the extract obtained by the above method is usable even in the same form as in just after prepared, it is favorable to remove an insoluble content by means of filtration, fractionation, fractional precipitation, decantation and/or centrifugal separation, then distill off the organic solvent and purify by means of salting, out or the like, depending on the final use.
<P>PROBLEM TO BE SOLVED: To output electronic medical records which are easy for a patient to understand by a medical examination support device.  <P>SOLUTION: Electronic medical records for a patient 10 include a medical examination record portion 12, a keyword list portion 14 where technical terms included in the medical examination records are arranged and a technical term contents portion 16 where the contents of the respective technical terms are described. The medical record portion 12 is configured so as to be outputted by a conventional electronic medical record system, and the medical examination contents by a doctor or the like are written by using professional predicates. The keyword list portion 14 is configured to extract and arrange technical terms which seem difficult for a patient to understand from the medical examination portion 12 by automatic retrieval. A dictionary database is retrieved so that the contents of the respective technical terms can be written in the technical term contents portion 16.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Although multimorbidity is highly prevalent, health care systems are designed for the management individual diseases. New strategies are needed to help general practitioners to provide appropriate personalized care to patients. The World Health Organization (WHO) has included comorbidity between depression and a chronic disease as one of the 10 main priorities in global public health. Studies in meta-analysis confirm that the 2 main interventions of first choice for depression are pharmacotherapy and/or psychotherapy, with similar results in the short term but superior in the long term for psychological treatments. Given the difficulty of delivering face to face psychological treatments (high costs) alternative models of delivering treatments have been proposed, emphasizing the role of technologies like Internet. The aim of this study is to assess the efficacy in Primary Care (PC) of a low intensity psychological intervention (8 weeks) applied using Information and communication technologies (ICTs) for the treatment of multimorbidity in PC (depression and diabetes/low back pain) by a randomized controlled trial (RCT). Our main hypothesis is that improved usual care combined with psychological therapy applied by ICTs, will be more efficacious to improve the symptomatology of multimorbidity, compared to a group with only improved treatment as usual three months after the end of treatment. A protocol will be design that combines face to face intervention with a supporting online program that will be tried in a RCT conducted in 3 different regions (Andalucía, Aragón, y Baleares). 180 participants diagnosed with depression and diabetes/low back pain will participate in the RCT. It´s proposed a coordinated study by 4 highly experienced groups with great possibilities of translation and transference to usual clinical practice.
Compositions and methods for the assessment of T cell receptor variable subunits. The present invention provides nucleotide sequences for the evaluation of the expression of TCRV families. These nucleotides sequences were obtained through a bioinformatic investigation of the nucleotide sequences for TCRV.alpha. and TCRV.beta. families. The nucleotide sequences of the present invention uniquely recognize each and every subfamily and alleli c member of a particular TCRV family, while at the same time not recognizing t he members of any other TCRV family. This unique expression recognition profile of the nucleotide sequences of the present invention provides great utility for the assessment of TCR families in a clinical setting, such as through polymerase chain reactions, gene chip technology, and direct electrophoretic measurement of DNA or RNA.
BACKGROUND: Trauma represents a significant global health challenge.The development of an effective scoring tool capable of predicting mortality risk in trauma cases is essential. This study aimed to investigate the combined effects of quick sequential organ failure assessment (qSOFA) and hypothermia (H) along with prothrombin time (PT) in predicting the prognosis of patients with severe trauma.
METHODS: A retrospective cohort study was conducted to analyze data from severe trauma patients in the Trauma Database of the Trauma Center at the Second Affiliated Hospital of Soochow University between January 2017 and December 2021. Patients were categorized into survival and non-survival groups based on clinical outcomes. Baseline and clinical data were compared between the groups, and prognostic factors were explored using logistic regression analysis. Receiver operating characteristic (ROC) curves generated by 10-fold cross-validation using the caret in R programming language were used to assess the predictive efficacy of Injury Severity Score (ISS) and qSOFA + H + PT score for trauma patient mortality.
RESULTS: A total of 509 severe trauma patients (377 males and 132 females) were included, with a median age of 53 years (range: 42-65 years). The mortality rate was found to be 23.4%. Logistic regression analysis revealed that age, ISS, and qSOFA + H + PT were significant predictors of death in severe trauma patients, with odds ratios of 1.035 (95%CI:1.014-1.057), 1.052 (95%CI:1.017-1.090), and 6.124 (95%CI:3.107-12.072), respectively (P < 0.05). The predictive efficacy of ISS and qSOFA + H + PT for mortality prediction was 0.742 and 0.816, respectively.The predictive efficacy of qSOFA + H + PT for emergency blood transfusion and operation was 0.743 and 0.702.
CONCLUSION: qSOFA + H + PT are identified as significant predictors to the death of severe trauma patients. They could be utilized as early intervention indicators in emergency departments, facilitating clinical management strategies such as emergency blood transfusion, emergency operation, and prognosis prediction.
A wrap for a non-human animal comprises: a wrap for a non-human animal comprises: an elastic portion; an exterior surface; and an antimicrobial coating applied to the exterior surface. The antimicrobial coating includes a silane quaternary ammonium ion or salt thereof. The exterior surface can adhere to itself. The elastic portion can comprise natural rubber. The silane quaternary ammonium ion or salt thereof is one or more of: 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium ion, 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium ion, or 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. The antimicrobial coating applied to the exterior surface imparts antimicrobial properties onto the wrap. The antimicrobial coating can be applied to the wrap by applying a solution that includes the silane quaternary ammonium ion or salt thereof to the exterior surface. The silane quaternary ammonium ion or salt thereof can be between 0.1 percent and 10 percent by weight of the solution.
To explore the therapeutic effect of Huoxue Huayu Decoction on limb swelling in the late stage of bone injury and its influence on motor function. Mainstream databases were searched by inputting the keywords "Huoxue Huayu Decoction" and "bone injury swelling". According to the research scope, 13 articles with a total of 1414 patients were screened out and divided into an observation group (n=707 cases) and a control group (n=707). The clinical effects, degree of limb swelling, recovery of motor function and incidence of adverse reactions of the two groups of patients treated with traditional Chinese medicine Huoxue Huayu Decoction and western medicine respectively in the treatment of limb swelling in the late stage of fracture were compared and analyzed. The clinical efficacy of the observation group was significant. The motor function score (VAS), limb swelling elimination time, hospitalization time, motor function recovery and adverse reaction incidence of the observation group were significantly better than those of the control group. The traditional Chinese medicine Huoxue Huayu Decoction is effective for limb swelling in the late stage of bone injury. It can relieve pain, reduce hospitalization time and has high drug safety.
Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized. As these proteins are highly immunogenic, and the upper epithelium is an immune-privileged site, this spatial restriction aids immune evasion. Many decades of work have contributed to the current understanding of how this restriction occurs at a molecular level. This review will examine what is known about late gene expression in HPV-infected lesions and will dissect the intricacies of late gene regulation. Future directions for novel antiviral approaches will be highlighted.
Subjects receiving IV colistin undergo a 2 day up-titration to a maximum dose of 5 mg/kg/day, divided into twice daily (BID) dosing, for a total treatment of 14 days. The drug is infused over 30 minutes BID. Steady state plasma concentrations on day 3 of therapy (on 2nd- 3rd dose once at goal dosing) will be measured; specifically, colistin peak (30 minutes after infusion), midpoint (6 hour) and trough (30 minutes prior to next infusion).
More than 60% of individuals recovering from substance use disorder relapse within one year. Some will resume drug consumption even after decades of abstinence. The cognitive and psychological mechanisms that lead to relapse are not completely understood, but stressful life experiences and external stimuli that are associated with past drug-taking are known to play a primary role. Stressors and cues elicit memories of drug-induced euphoria and the expectation of relief from current anxiety, igniting an intense craving to use again; positive experiences and supportive environments may mitigate relapse. We present a mathematical model of relapse in drug addiction that draws on known psychiatric concepts such as the "positive activation; negative activation" paradigm and the "peak-end" rule to construct a relapse rate that depends on external factors (intensity and timing of life events) and individual traits (mental responses to these events). We analyze which combinations and ordering of stressors, cues, and positive events lead to the largest relapse probability and propose interventions to minimize the likelihood of relapse. We find that the best protective factor is exposure to a mild, yet continuous, source of contentment, rather than large, episodic jolts of happiness.