anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a prospective, randomized, open-label, blinded-endpoint evaluation, single-center Study. A total of 252 RISR patients are planned to be enrolled in Fuwai Hospital, China. Then those included subjects will be randomized to standard drug therapy (control group), standard drugs combined with lose-dose colchicine therapy (colchicine group) and standard drug combined with prednisone therapy (prednisone group). The primary endpoint of the current study is target lesion ISR confirmed by coronary angiography for 12 months, and the secondary endpoint is Major adverse cardiovascular events (MACE: a composite of death, non-fatal myocardial infarction, non-fatal stroke, and target vascular revascularization) and each MACE component, target lesion revascularization, or other coronary artery disease revascularization for 12 months. The safety endpoint is adverse reactions to colchicine, adverse reactions of prednisone, or discontinued medication due to adverse reactions. In summary, the present study is to provide new evidence and strategy about anti-inflammatory therapy for recurrent In-stent restenosis after coronary intervention.
Group 2: intravenous SF and paravertebral lidocaine. During anesthesia maintenance, a continuous intravenous infusion of 0.9% SF and an infusion of 2% lidocaine will be administered through the intraoperative paravertebral catheter at a rate of 0.1 ml/kg/h.
During the development of pleural fibrosis, pleural mesothelial cells (PMCs) undergo phenotypic switching from differentiated mesothelial cells to mesenchymal cells (MesoMT). Here, we investigated how external stimuli such as TGF-β induce HPMC-derived myofibroblast differentiation to facilitate the development of pleural fibrosis. TGF-β significantly increased di-phosphorylation but not mono-phosphorylation of myosin II regulatory light chain (RLC) in HPMCs. An increase in RLC di-phosphorylation was also found at the pleural layer of our carbon black bleomycin (CBB) pleural fibrosis mouse model, where it showed filamentous localization that coincided with alpha smooth muscle actin (αSMA) in the cells in the pleura. Among the protein kinases that can phosphorylate myosin II RLC, ZIPK (zipper-interacting kinase) protein expression was significantly augmented after TGF-β stimulation. Furthermore, ZIPK gene silencing attenuated RLC di-phosphorylation, suggesting that ZIPK is responsible for di-phosphorylation of myosin II in HPMCs. Although TGF-β significantly increased the expression of ZIP kinase protein, the change in ZIP kinase mRNA was marginal, suggesting a posttranscriptional mechanism for the regulation of ZIP kinase expression by TGF-β. ZIPK gene knockdown (KD) also significantly reduced TGF-β-induced upregulation of αSMA expression. This finding suggests that siZIPK attenuates myofibroblast differentiation of HPMCs. siZIPK diminished TGF-β-induced contractility of HPMCs consistent with siZIPK-induced decrease in the di-phosphorylation of myosin II RLC. The present results implicate ZIPK in the regulation of the contractility of HPMC-derived myofibroblasts, phenotype switching, and myofibroblast differentiation of HPMCs.NEW & NOTEWORTHY Here, we highlight that ZIP kinase is responsible for di-phosphorylation of myosin light chain, which facilitates stress fiber formation and actomyosin-based cell contraction during mesothelial to mesenchymal transition in human pleural mesothelial cells. This transition has a significant impact on tissue remodeling and subsequent stiffness of the pleura. This study provides insight into a new therapeutic strategy for the treatment of pleural fibrosis.
Forty apparently healthy smokers and non smokers (20 male, 20 female) will be recruited by advertising in the Twin Cities area. This will be done by the Tobacco Use Research Center. They will be screened in a phone call, then invited to come in for an orientation session at which consent will be obtained. Pregnant smokers will be excluded. They will visit the clinic weekly for 2 months and once monthly for 4 months for a total of 6 months participation.

At each visit they will drink 5 ml of 50:50 ethanol:water containing 10 ug \[D10\]phenanthrene. They will then collect their 24h urine and return it to the clinic. The urine will be analyzed for \[D10\]phenanthrene tetraol. The goal of the study is to determine the longitudinal stability of the amount of \[D10\]phenanthrene-tetraol in urine.
Epilepsy is a chronic disease of brain dysfunction, which arises from imbalance between excitatory and inhibitory activities in neural circuits. Previously, we reported that peptide Martentoxin (MarTX), from scorpion Buthus martensii Karsch, displayed antiseizure activities by specifically inhibiting BK(α + β4) channel currents. Injection of MarTX into the hippocampal region of mice significantly alleviated convulsive seizures. However, intravenous injection of MarTX had no antiepileptic efficacy due to the blood-brain barrier (BBB). To address this, here, we designed cell-penetrating peptide TAT-modified MarTX, in which the linker containing three glycines was put between TAT and the N-terminus of MarTX (forming MTX-N-TAT) or between TAT and the C-terminus of MarTX (forming MTX-C-TAT), respectively. We prepared them in a large amount through Escherichia coli overexpression system and then probed their antiseizure activities. Our results indicated that intravenous injection of MTX-C-TAT showed significant therapeutic efficacy of antiseizure. It increased seizure latency, reduced the total seizure duration and the number of seizures at stages 3, 4, and 5, inhibited hippocampal neuronal hyperexcitability, and exhibited neuroprotective effects on hippocampal neurons. These studies implied that MTX-C-TAT displayed intravenous antiseizure activities properly through crossing BBB and would be a potential antiepileptic drug in the future.
INTRODUCTION: Identifying the mucosal wave (MW) is essential when studying the voice; however, its characterization and perceived measurement during laryngeal stroboscopy (LS) are not well defined or standardized because of the subjectivity of its interpretation. This article proposed and validated a scale that characterized and approximated MW measurement during LS, applied it to participants divided into a healthy group and groups with free edge conditions, and identified differences between them.
METHODS: This is a descriptive and clinical validation study of the "VASQ (Vertical axis, Anteroposterior axis, Symmetry and Quantity) mucosal wave score" scale based on stroboscopy images of 137 adult men and women divided into a control group and functional and organic pathology groups. The images were analyzed by three evaluators according to an established protocol. Measurements dictating the reproducibility and validity criteria as well as the MW score in each group were obtained.
RESULTS: The reliability of the scale was α = 0.90, internal consistency success rate was 91%, intra-observer reliability was 0.83, inter-observer reliability was 0.83, content validity coefficient was 0.92, and factor loading was 0.37-0.53. The MW total score values between 5 and 6 were established as a reference for normality (P < 0.05). Organic pathology showed lower MW score values (P < 0.05), and functional pathology to a lesser extent (P > 0.05).
CONCLUSIONS: The proposed scale is a consistent, valid, and reliable tool. Its widespread application would favor commonly used terminology and facilitate quantitative comparisons in future studies.
Twenty-five participants who are flagged by the screening tool as having high risk of undiagnosed peripheral artery disease (PAD) will be randomized to have their primary care physician receive an electronic health record message regarding their high risk of having PAD and a recommendation will be made to have the participant referred for non-invasive testing called Ankle Brachial Index (ABI) testing to confirm diagnosis. For individuals who undergo ABI testing and are confirmed to have PAD, they and their physicians will be provided with American Heart Association Guidelines for the management of PAD. Each participant's medical record will be reviewed for 6 months to evaluate for referral for ABI testing, referral to cardiovascular specialists (vascular medicine, vascular surgery or a cardiologist), and for initiation of new cardiovascular related medications such as an antiplatelet, statins, or anti-hypertensive medications.
HZT-501 is a combination product including ibuprofen and the acid reducing agent famotidine. The study is designed to determine whether the combination product reduces the rate of ulcer development in subjects who require long-term daily use of ibuprofen.

Subjects will be assigned randomly, in approximately a 2:1 ratio, to treatment with either HZT-501 (ibuprofen 800 mg/famotidine 26.6 mg) or ibuprofen (800 mg) three times daily for a 24 week treatment period or until they develop either an endoscopically-diagnosed upper gastrointestinal ulcer and/or prohibitive toxicity. Subjects will visit the study center for Screening and at Weeks 4, 8, 16, and 24. Physical exams will be performed, and clinical laboratory measurements made, at selected times during the study. Endoscopic exams will be performed during Screening and at Weeks 8, 16, and 24. Subjects will be contacted four weeks following study completion.
The invention relates to a Yunnan rhodiola anti-acne extracting solution and a preparing method thereof and aims at providing a novel traditional Chinese medicine extracting solution capable of removing acnes comprehensively, fast in effect taking and safe. The traditional Chinese medicine extracting solution is prepared from, by weight, 5-60 parts of white peony flowers, 4-55 parts of all grass of nephrolepis cordifolia(L.)Presl, 3-25 parts of roots of red-rooted salvia, 4-40 parts of bauhinia roots, 3-25 parts of mulberry and 3-30 parts of radix scutellariae. An alcohol extracting solution and a water extracting solution are related in the preparing method. The alcohol extracting solution is prepared in the way that the white peony flowers, the all grass of nephrolepis cordifolia(L.)Presl and the roots of red-rooted salvia are weighed according to the formula, and subjected to heated reflux extraction with ethyl alcohol at the concentration of 70%. The water extracting solution is prepared in the way that the bauhinia roots, the mulberry and the radix scutellariae are weighed according to the formula and decocted with water, medicine liquor is obtained through filtering and purified, then the water extracting solution and the alcohol extracting solution are mixed, and the Yunnan rhodiola anti-acne extracting solution is prepared. The Yunnan rhodiola anti-acne extracting solution serves as a functional ingredient, is mainly used for producing anti-acne external medicine and acne removing skin care products and can also be used for oily scurf removing hair products, and the adding aquantity ranges from 5% to 50%.
The present invention relates to citrate lyase polypeptides and to nucleic acid molecules coding for such polypeptides. Citrate lyase is transcriptionally regulated in adipose tissue, suggesting involvement in a novel pathway in energy expenditure, downstream of fatty acid metabolism. This makes CitE an attractive drug target for treating and/or preventing diseases such as obesity. Accordingly, the invention refers to the novel mammalian CitE-polypeptide, as well as homologs and functionally equivalent variants thereof. Further, the invention refers to the nucleic acid sequence encoding the novel protein and to vectors for expressing the protein in various organisms. The invention also refers to methods for expressing the protein in said organisms and for purifying the protein upon overexpression. Moreover, the invention refers to a methods wherein CitE is used for screening for substances that affect the activity of CitE.
NEW MATERIAL:A thrombin binding substance derived from humans. Molecular weight; 88000+ or -10000 in the reduced state, and 71000+ or -10000 in the nonreduced state. Isoelectric point; 4.2+ or -0.5pH. Affinity; Strong affinity for thrombin. Stability; Stable at 2-10pH and stable to a modifier, e.g. sodium dodecyl sulfate or urea, and treatment with pepsin. USE:A fibrinolytic promoter and anticoagulant capable of bonding with thrombin to enhance specifically the activation of protein C and prolonging the blood coagulation time. PREPARATION:A pulverized human placenta is extracted with a buffer solution, e.g. tris hydrochloric acid buffer solution, containing a nonionic surfactant, e.g. Triton X-100 or Lubrol PX, and the resultant extract is then separated and purified by affinity chromatography with a conjugate of thrombin with a carrier, e.g. diisopropylphosphoro-thrombin-agarose, to give the titled substance.
Participants in the control group will receive what is usual care in each of the participating countries for 24 weeks (primary trial outcome). After 24 weeks, they will also receive the navigation intervention (NavCare-EU) (fast-track RCT).
Introduction: Surgical site infections (SSIs) are an important quality measure. Identifying SSIs often relies upon a time-intensive manual review of a sample of common surgical cases. In this study, we sought to develop a predictive model for SSI identification using antibiotic pharmacy data extracted from the electronic medical record (EMR). Methods: A retrospective analysis was performed on all surgeries at a Veteran Affair's Medical Center between January 9, 2020 and January 9, 2022. Patients receiving outpatient antibiotics within 30 days of their surgery were identified, and chart review was performed to detect instances of SSI as defined by VA Surgery Quality Improvement Program criteria. Binomial logistic regression was used to select variables to include in the model, which was trained using k-fold cross validation. Results: Of the 8,253 surgeries performed during the study period, patients in 793 (9.6%) cases were prescribed outpatient antibiotics within 30 days of their procedure; SSI was diagnosed in 128 (1.6%) patients. Logistic regression identified time from surgery to antibiotic prescription, ordering location of the prescription, length of prescription, type of antibiotic, and operating service as important variables to include in the model. On testing, the final model demonstrated good predictive value with c-statistic of 0.81 (confidence interval: 0.71-0.90). Hosmer-Lemeshow testing demonstrated good fit of the model with p value of 0.97. Conclusion: We propose a model that uses readily attainable data from the EMR to identify SSI occurrences. In conjunction with local case-by-case reporting, this tool can improve the accuracy and efficiency of SSI identification.
HepaGam B contains maltose which can interfere with certain types of blood glucose monitoring systems. [See Warnings and Precautions (5.2).] Only testing systems that are glucose-specific should be used in patients receiving HepaGam B. This interference can result in falsely elevated glucose readings that can lead to untreated hypoglycemia or to inappropriate insulin administration, resulting in life-threatening hypoglycemia. The product information of the blood glucose testing system, including that of the test strips, should be carefully reviewed to determine if the system is appropriate for use with maltose-containing parenteral products. If any uncertainty exists, contact the manufacturer of the testing system to determine if the system is appropriate for use with maltose-containing parenteral products.
PURPOSE: A water-in-oil type transparent composition for UV protection and a method for manufacturing the same are provided to ensure formulation stability by controlling difference of refractive index between an oil phase part and an aqueous phase part by 0.05 or less. CONSTITUTION: A water-in-oil type transparent composition for UV protection contains 20-80 wt% of an oil phase part and 20-80 wt% of an aqueous phase part. The oil phase part contains oil, a surfactant, and a UV protection agent. The aqueous phase part contains a moisturizer, purified water, and the UV protection agent. A method for manufacturing the composition comprises: a step of heating the oil phase part at 70-90 deg. C and measuring refractive index; a step of dissolving the aqueous phase part at room temperature and controlling the difference of refractive index between the oil phase part and the aqueous phase part by 0.05 or less; a step of mixing the oil phase part and the aqueous phase part and stirring at 3,000-3,500 rpm for 15-20 minutes; and a step of cooling the mixture at 30-40 deg. C. [Reference numerals] (AA) Existing invention 1; (BB) Existing invention 2; (CC) Present invention
86 participants with chronic schizophrenia in two different hospitals in northern Taiwan were recruited in this study. All participants were randomized into experimental and control groups through block randomization. After randomization, the participants in control group received routine care and the others in experimental group received Narrative Enhancement and Cognitive Therapy(NECT) which contains 20 times group meetings. The research tools include demographic data, the Internalized Stigma of Mental Illness Scale (ISMIS), the Discrimination and Stigma Scale (DISC), Rosenberg self-Esteem scale (RSES), Beck Depression Inventory (BDI-II) and Herth Hope Index (HHI). The questionnaires were collected for three times, including before the intervention, 12 weeks after intervention, and after the end of intervention. The collected data were analyzed by IBM SPSS 24.0 statistical software. The descriptive statistics include mean, standard deviation, minimum, maximum, frequency distribution, and percentages; the Generalized estimating equations (GEE) were used to explore the effect of Narrative Enhancement and Cognitive Therapy on self-stigma, self-esteem, depressive symptoms and hope in patients with schizophrenia after controlling demographic data.
Sepsis,especially severe sepsis is a major cause of admission to the intensive care unit (ICU) and death. In USA, the incidence of sepsis is about 3/1000 population. However, the incidence of sepsis varies among different clinic trails. Between 6 and 54% of patients admitted to ICUs have severe sepsis and the mortality rate for these patients varies from 20 to 60%. There is no exactly results of incidence of sepsis in China.

In addition, clinician empirical select antibiotic according to the epidemiology of sepsis, however, the etiology of sepsis is various in different studies. In EPIC II study, the organisms of sepsis include Gram-positive microorganisms (69.8%),Gram-negative microorganisms(62.2%) and fungi (17%). In China, the MDRO is much higher than western country. In contrast to EPIC II study, one study in China showed that the organisms of sepsis include Gram-positive microorganisms (14.5%),Gram-negative microorganisms(62.5%) and fungi (2.2%). Therefore, it is necessary to conduct a study about epidemiology of sepsis in China.
Some studies suggest that administering the antibiotics prior to skin incision decrease the incidence of post partum infectious morbidities without increasing the risks to the baby from the exposure to the antibiotics. Our investigation will validate these findings in a larger series of patients. We will be conducting a prospective controlled randomized trial that will compare both methods of antibiotic prophylaxis. All patients undergoing cesarean delivery will be eligible except for the patients with the diagnosis of chorioamnionitis. One group will receive Cefazolin 1gm intravenous + Azithromycin 500mg intravenous 30-60 minutes prior to incision. The second group will receive the same antibiotics immediately after cord clamp. The primary outcomes will be endometritis, wound infection, neonatal sepsis evaluations, proven cases of neonatal infection. Secondary outcomes will be patients that required post procedure antibiotics, the duration of treatment for mother and neonate and the pattern of antibiotic resistance in microorganisms isolated and characteristics of the neonatal bowel flora.
The invention discloses a gynecological pill and a preparation method thereof. The gynecological pill is prepared from radix sophorae flavescentis, cortex phellodendri chinensis, rhizoma coptidis, fructus cnidii, fructus forsythiae, herba taraxaci, radix gentianae, catechu, olibanum, myrrha, borneol and sangusis draconis. Formula bulk drugs are porphyrized and disintegrated, and are mixed; afterwards, an appropriate amount of purified water is added into an obtained first mixture; an obtained second mixture is sufficiently mixed and is made into a soft material; a 14-mesh sieve is selected and used for granulation; granules are dried; the granules which are uniform in size are selected and taken, and are put into a coating pan; afterwards, the coating pan is rotated; a small amount of water is sprayed into the coating pan; a small amount of medicinal powder is added into the coating pan; coated pills in required size are made once through repeated operation; subsequently, the coated pills are subjected to low-temperature drying and are selected, so as to obtain the pills. A formula comprising pure natural traditional Chinese medicinal materials is adopted for the gynecological pill; the gynecological pill has the functions of clearing away heat and toxic material, eliminating dampness, killing parasites to relieve itching, activating blood circulation, easing pain, stopping bleeding and promoting tissue regeneration. Further, the dosage form of the gynecological pill is simple; the gynecological pill is enveloped by using absorbent cotton gauze, is convenient to use, and can be used for effectively treating various gynecological inflammations. The preparation method is simple in process, has a low requirement on a device, is environmentally friendly, and is suitable for industrialized enlarged production.
One in every four newborns suffers from congenital heart disease (CHD) that causes defects in the heart structure. The current gold-standard assessment technique, echocardiography, causes delays in the diagnosis owing to the need for experts who vary markedly in their ability to detect and interpret pathological patterns. Moreover, echo is still causing cost difficulties for low- and middle-income countries. Here, we developed a deep learning-based attention transformer model to automate the detection of heart murmurs caused by CHD at an early stage of life using cost-effective and widely available phonocardiography (PCG). PCG recordings were obtained from 942 young patients at four major auscultation locations, including the aortic valve (AV), mitral valve (MV), pulmonary valve (PV), and tricuspid valve (TV), and they were annotated by experts as absent, present, or unknown murmurs. A transformation to wavelet features was performed to reduce the dimensionality before the deep learning stage for inferring the medical condition. The performance was validated through 10-fold cross-validation and yielded an average accuracy and sensitivity of 90.23 % and 72.41 %, respectively. The accuracy of discriminating between murmurs' absence and presence reached 76.10 % when evaluated on unseen data. The model had accuracies of 70 %, 88 %, and 86 % in predicting murmur presence in infants, children, and adolescents, respectively. The interpretation of the model revealed proper discrimination between the learned attributes, and AV channel was found important (score 0.75) for the murmur absence predictions while MV and TV were more important for murmur presence predictions. The findings potentiate deep learning as a powerful front-line tool for inferring CHD status in PCG recordings leveraging early detection of heart anomalies in young people. It is suggested as a tool that can be used independently from high-cost machinery or expert assessment.