anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The increasing environmental presence of nanoplastics (NPs) has raised concerns about their potential impact on biological systems. We investigated the repercussions of polymethyl methacrylate (PMMA) NPs exposure on normal gastric epithelial cells and revealed a pronounced increase in senescence-associated β-galactosidase activity and G1 phase cell cycle arrest. Our study demonstrated a dose-dependent increase in reactive oxygen species (ROS) and DNA damage, underscoring the pivotal role of ROS in PMMA NPs-mediated effects, a novel contribution to the existing body of knowledge dominated by polystyrene particles. Furthermore, we explored the influence of PMMA NPs on DNA damage response mechanisms, highlighting the significant inhibition of nonhomologous end-joining (NHEJ). Our findings help to elucidate the consequent genomic instability, as evidenced by increased chromosomal aberrations and micronuclei formation. By connecting these cellular manifestations to organism-level effects, we hypothesize that PMMA NPs play a critical role in aging processes. Our work revealed an activated cGAS-STING signaling pathway after PMMA NPs exposure, which correlated with aging-related inflammation and behavioral changes in mice. Importantly, our study provides comprehensive evidence of PMMA NPs-induced premature aging in gastric epithelial cells, shedding light on the molecular intricacies underlying DNA damage, repair impairment, and inflammation. Our research prompts heightened caution regarding the risks of NPs exposure and calls for further investigation into the broader implications of these environmental pollutants on aging processes in higher organisms.
Arm 1 will receive radiotherapy on day -14 and pembrolizumab on day -7. Subjects in all arms will undergo surgery on day 0 and follow the same postoperative blood sampling and safety schedule.
Participants received a HFIT device to treat their chronic pain and took part in a digital MSK program, which provided customized exercise therapy sessions, educational articles, and access to coaches and physical therapists. Participants were encouraged to use the HFIT device for at least 1 hour daily for 4 weeks.
PURPOSE:To prepare a sustained release preparation easy in production, enabling to control the release-starting time and release period of an active ingredient, and having an excellent sustained release activity. CONSTITUTION:A sustained release preparation is produced by adding (C) a physiologically active substance, e.g. physiologically active peptide such as a peptide related to a calcitonin gene, to a carrier comprising (A) a water-soluble polymer having a cellulose skeleton, e.g. methylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, especially hydroxypropylcellulose and (B) a saccharide, preferably lactose or glucose. The components A, B and C are compounded in amounts of 10-90wt.%, 1-40wt.%, and 0.0001-30wt.%, respectively. The preparation is preferable as an internally embedding type sustained release preparation, concretely, an intracerebrally embedding type sustained release preparation, capable of being embedded in vivo to express an effect on a pathologic state for which a therapeutic effect can not be expected by a parenteral administration method, a local administration method, etc.
Scrub Typhus Exposed (STE, n=80) Cohort. Single blood sample collection.
The low-fat diet was based on the algorithm used to restrict fat and calorie intake in the Diabetes Prevention Program. The daily goals for fat intake was based on an algorithm to reduce total calorie intake to achieve a one pound weight loss per week with 25% of calories from fat.
The NIMH Research Domain Criteria (RDoC) initiative seeks to further a long-range goal of contributing to diagnostic systems as informed by research on genetics, neuroscience, and behavior. The RDoC approach is based on identifying the most elemental units of analysis relevant to psychiatric disorders (such as genes and molecules) and using this matrix as a framework for investigation. In this case-control family study, the investigators will be using self-report questionnaires and computer-based tests to develop diagnostic methods for neuropsychiatric disorders in children, their siblings, and their parents. They will do this by recruiting "normal" and "affected" children, their siblings, and their parents. They will look at the subject, sibling, and parents to determine if psychiatric disorders are inherited. "Affected" children, ages 6-12, are those who have been diagnosed with a psychiatric disorder. Participants will undergo a battery of questionnaires/evaluations and a blood draw. The investigators will determine if the questionnaires and tests that reflect the constructs (such as reward prediction and willingness to work) predict psychopathology and impairment. The blood draw will be genotyped to determine if the measured constructs are associated with neuropsychiatric candidate genes, cross-disorder candidate gens and a cross-disorder polygenic score.
PURPOSE:To obtain the titled complex, useful as a remedy for thrombosis, and having the fibrin adsorptivity without systemic hemorrhagic tendency, by reacting a fibrin adsorbing protein with urokinase in the presence of a specific protein binding reagent. CONSTITUTION:A fibrin adsorption protein, e.g. a heavy chain derived from plasmin, is reacted with urokinase in the presence of a protein binding reagent expressed by the formula (A and B are lower alkylene; l and m are 0 or 1) to give the aimed complex of the fibrin adsorbing protein and urokinase. The thrombolytic urokinase has no adsorptivity for the fibrin which is a proteinic component constituting the thrombus, and intravenously injected urokinase will be rapidly metabolized and excreted. The above-mentioned complex has the fibrin adsorptivity and is capable of exhibiting sufficient prolonged thrombolytic action without side effects, e.g. systemic hemorrhagic tendency.
Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compared to normal cells, tumor cells reprogram metabolic processes more efficiently, converting nutrient supplies into glucose, amino acid and lipid required for malignant proliferation and progression. Non-coding RNAs(ncRNAs) are a class of functional RNA molecules that are not translated into proteins but regulate the expression of target genes. NcRNAs have been demonstrated to be involved in various aspects of energy metabolism, including glycolysis, glutaminolysis, and fatty acid synthesis. This review focuses on the metabolic regulatory mechanisms and clinical applications of metabolism-regulating ncRNAs involved in breast cancer. We summarize the vital roles played by metabolism-regulating ncRNAs for endocrine therapy, targeted therapy, chemotherapy, immunotherapy, and radiotherapy resistance in breast cancer, as well as their potential as therapeutic targets and biomarkers. Difficulties and perspectives of current targeted metabolism and non-coding RNA therapeutic strategies are discussed.
This arm is the control. Formula-75/Formula-100 are the standard formula recommended by WHO to treat severely malnourished children.
A patient monitoring device having an entertainment function comprises a signal acquiring unit, a signal receiving unit, a main control unit, a special signal processing unit, a storage unit, and an audio and video output unit. The signal acquiring unit comprises an entertainment signal acquiring unit and a physiological parameter signal acquiring unit. The special signal processing unit comprises an entertainment signal processing unit, a parameter signal processing unit and an alarm signal processing unit. The entertainment signal processing unit comprises a receiving unit, an entertainment device actuating unit and a signal judging unit. The audio and video output unit comprises a monitoring specific display device and a monitoring specific loudspeaker, as well as an entertainment specific display device and an entertainment specific loudspeaker. The alarm signal processing unit comprises an alarm detecting unit, an alarm judging unit, an alarm actuating unit and an alarm storage unit. A method for operating the patient monitoring device having an entertainment function is also provided.
FIELD: medicine, phytotherapy, parapharmaceutical industry. SUBSTANCE: invention relates to production of preparations for curative and prophylactic designation. Proposed biological supplement "Uspokaivajuschie travy" comprises dry concentrates of valerian, hawthorn and motherwort tinctures, dry concentrate of common balm infusion, coriander, nutmeg, starch, bran, calcium stearate and sugar taken in the definite ratio of components. Invention expands assortment of alternative general tonic and sedative agents for compensation of individual intolerance to some components of the known preparations. EFFECT: enhanced and valuable medicinal properties of supplement. 3 tbl
PROBLEM TO BE SOLVED: To always uniformly and efficiently mix a powder and a liquid, and at the same time, eliminate the residue of the unhumidified powder by injecting the liquid into a capsule in which a calcium phosphate powder is housed, mixing the capsule for a specified period of time by fixing the capsule in a mixing device, and then, taking out a product from the capsule. SOLUTION: A liquid is injected into a capsule in which a calcium phosphate powder is housed, preferably under an aseptic state. Then, the capsule is fixed in a mixing device, preferably in a desorption bag, and after mixing the capsule for a specified period of time, a product is taken out from the capsule. For example, the capsule is rapidly shaken in the horizontal direction and fixed in a commercial mixing device for dental use, and the powder and the liquid are always uniformly and efficiently mixed. By this method, the mixing time for, e.g. α-BSM (bone substituting material) can be reduced to 15 sec or lower, and at the same time, a compression strength which is higher compared with a manual mixing, can be ensured. Also, the same effect can be seen in the case of a bio-cement.
PROBLEM TO BE SOLVED: To obtain a multi-coating type hair-growing agent capable of giving a hair-growing effect under a multi-coating treatment comprising repeated coating and drying treatments by adding a specific polymer to one or both of two kinds of hair-growing solutions and, if desired, further adding a specified sugar. SOLUTION: This hair-growing agent comprises two kinds of solutions containing hair-growing ingredients, wherein at least one of the solutions contains one or more kinds of hydrophilic polymers. The hair-growing ingredient includes Glycyrrhiza extract, dipotassium glycyrrhizinate, Swertia japonica extract, capsicum tincture, and L-menthol. The hydrophilic polymer includes ammonium alginate, carboxymethylcellulose sodium salt and polyvinyl alcohol. If desired, glucose, maltose, fructooligosaccharide, etc., may be added to at least one of the solutions. The solvent for the solutions is preferably ethyl alcohol, isopropyl alcohol, etc.
An agent (A) that induces, in presence of cytokines, proliferation and/or maturation of specific cytotoxic T lymphocytes (CTL) in a population of peripheral blood mononuclear cells, is new. The CTL are directed against at least one antigen expressed by a target, especially tumor, cell. An agent (A) that induces, in presence of cytokines, proliferation and/or maturation of specific cytotoxic T lymphocytes (CTL) in a population of peripheral blood mononuclear cells, is new. The CTL are directed against at least one antigen expressed by a target, especially tumor, cell. (A) consists of tumor cells that: (a) express at least one MHC (major histocompatibility complex) molecule; and (b) are loaded with peptide antigen (PAg) that functions as Ag and has good affinity and avidity for T cells. Independent claims are also included for the following: (1) therapeutic compositions and vaccines containing (A); in vitro stimulation of the growth or maturation of specific CTL using (A); and (2) Ag-specific CTL produced by the method of (2).
Disclosed is a method for execution by a computing device. The method involves receiving user input regarding an ailment, and responsive to the user input, playing media content relating to the ailment. The media content can for example include guided meditation for coping with the ailment. In accordance with an embodiment of the disclosure, the method also involves, upon an opportunity to participate in a clinical trial relating to the ailment, presenting details of the opportunity. In this manner, people can be targeted for participation in the clinical trial based on their consumption of media content. In some implementations, responsive to user input regarding interest to participate in the clinical trial, the method also involves transmitting a message over a network indicating that interest. This can enable details of interested parties to be compiled by a server.
The participants are allocated to intake the fifteen capsules per day, for example, five capsules three times per day. Altogether the fifteen capsules contains 5.5 g dietary fiber in psyllium husk.
Some embodiments of a workflow management system to process medical image data generated by a medical imaging device have been presented. In one embodiment, a user selects a workflow template with a predefined set of image processing stages, and applies the workflow template to the medical image data. Each of the predefined set of image processing stages in the workflow template includes one or more image processing operations. Each of the image processing operations is capable of generating metadata for processing the medical image data. The medical image data is then processed through each of the predefined image processing stages. The result of processing is a collection of metadata. Each metadata in the collection can be applied to the medical image data to generate a medical image view.
# Background and Rationale Mantle cell lymphoma (MCL) is a rare subtype of lymphoma, accounting for about 3-6% of all non-Hodgkin's lymphoma. It is clinically prevalent in the elderly and men, commonly with gastrointestinal tract involvement. Since about 80% of patients present with advanced stage disease at diagnosis, the prognosis is very poor. Mantle cell lymphoma is less frequent in Korean than in Western countries, accounting for about 2% of all non-Hodgkin's lymphoma cases, with very poor treatment outcome as Western countries.

In Korea, the clinical information about patients with MCL is very scarce so far and does not reflect recent treatment patterns. Firstly, the incidence in Korea is relatively lower than that in Western countries, with only about 100 patients a year. Secondly, due to substandard national health insurance regulations in Korea, it was not until recently that ibrutinib for relapsed/refractory MCL was approved for coverage by the National Health Insurance. In this context, the study was designed to investigate the efficacy and safety of ibrutinib in patients with relapsed or refractory MCL in Korea.
Rice blast is a major problem in agriculture, affecting rice production and threatening food security worldwide. This disease, caused by the fungus Magnaporthe oryzae, has led to a lot of research since the discovery of the first resistance gene, pib, in 1999. Researchers have now identified more than 50 resistance genes on eight of the twelve chromosomes in rice, each targeting different strains of the pathogen.These genes are spread out across seventeen different loci. These genes, which primarily code for nucleotide-binding and leucine-rich repeat proteins, play an important part in the defense of rice against the pathogen, either alone or in combination with other genes. An important characteristic of these genes is the allelic or paralogous interactions that exist within these loci. These relationships contribute to the gene's increased capacity for evolutionary adaptation. The ability of resistance proteins to recognize and react to novel effectors is improved by the frequent occurrence of variations within the domains that are responsible for recognizing pathogen effectors. The purpose of this review is to summarize the progress that has been made in identifying these essential genes and to investigate the possibility of utilizing the allelic variants obtained from these genes in future rice breeding efforts to increase resistance to rice blast.
PCT No. PCT/EP86/00682 Sec. 371 Date Jul. 22, 1987 Sec. 102(e) Date Jul. 22, 1987 PCT Filed Nov. 26, 1986 PCT Pub. No. WO87/03474 PCT Pub. Date Jun. 18, 1987.Process for the simultaneous dyeing and permanent shaping of white and gray hair, in which the hair is first treated with a shaping composition, then rinsed with water and treated with a fixing composition, characterized in that a shaping composition is used which comprises a content of at least one red-violet dyeing xanthene dyestuff and a fixing composition with a content of at least one blue dyeing anthraquinone dyestuff. The process, according to the invention, offers the advantage that the unwanted yellow shade in white and gray hair is permanently removed during the hair shaping treatment without an additional dyeing treatment.
During cardiac surgery with cardiopulmonary bypass (CPB), efficient anticoagulation is required in order to avoid microscopic clot formation or, in worst case, massive lift threatening thrombus formation. Heparin is by far the most common drug used to prevent blood from coagulating during CPB. Activated clotting time (ACT) is a point-of-care test of fibrin clotting time that has to be well prolonged to initiate safe CPB.

Following weaning from CPB, heparin is reversed by protamine. Administration of excess doses of protamine may have a deleterious effect on coagulation and contribute to postoperative bleeding with need of blood transfusions. In connection with CPB management, heparin and protamin doses are commonly calculated using body weight and ACT. However, a new Heparin-Protamin-Calculation computer program (HeProCalc) has been developed to provide patient titrated dosing of both heparin and protamin. However, any benefits regarding postoperative bleeding and transfusions has not been thoroughly investigated.
Gastric Cancer (GC) is one of the most prevalent cancers worldwide. As the currently available therapeutic options are invasive, new and more benign options are being explored. One of which is Apigenin (Api), a natural flavonoid found in fruits and vegetables, such as celery, parsley, garlic, bell pepper and chamomile tea. Api has known anti-inflammatory, -oxidant, and -proliferative proprieties in several diseases and its potential as an anticancer compound has been explored. Here we systematize the available data regarding the effects of Api on GC cells, in terms of cell proliferation, apoptosis, Helicobacter pylori (H. pylori) infection, and molecular targets. From the literature it is possible to conclude that Api inhibits cell growth in a dose- and time-dependent manner, which is accompanied by the reduction of clone formation and induction of apoptosis. This occurs through the Akt/Bad/Bcl2/Bax axis that activates the mitochondrial pathway of apoptosis, resulting in restriction of cell proliferation. Additionally, it seems that the anti-proliferative potential of Api on GC cells is particularly relevant in a more aggressive GC phenotype but can also affect normal gastric cells. This indicate that this flavonoid must be used in low-to-moderate doses to avoid side-effects induced by disturbance of the normal epithelium. In H. Pylori-infected cells, the literature demonstrates that Api reduces inflammation by diminishing the levels of H. pylori colonization, by preventing NF-kB activation and by diminishing the production of reactive oxygen specimens (ROS). Accordingly, in GC Api seems to regulate different hallmarks of cancer, such as cell proliferation, apoptosis, cell migration, inflammation and oxidative stress, demonstrating its potential has an anti-GC compound.
Methods and compositions are disclosed for treating or preventing adverse CNS effects produced by NMDA receptor hypofunction (NRH), including hypofunction induced by NMDA antagonist drugs, and hypofunction occurring as a causative or aggravating factor in schizophrenia. One method of this invention comprises administering an alpha-2 adrenergic ( alpha 2) receptor agonist drug along with an NMDA antagonist drug. The NMDA antagonist drug exerts a primary benefit in reducing excitotoxic brain damage, alleviating neuropathic pain, or preventing or avoiding tolerance or addiction to various types of drugs. The  alpha 2 agonist drug acts as a secondary or "safener" drug, to prevent the neurotoxic side effects that would be caused by the NMDA antagonist in the absence of the safener drug. Another method disclosed herein involves the use of an  alpha 2 agonist drug, by itself, to combat a different and naturally-occurring form of NMDA receptor hypofunction which occurs as a causative or aggravating mechanism in people suffering from schizophrenia. Although  alpha 2 agonists are usually not effective in treating long-standing cases of chronic schizophrenia, where pathological changes in the brain have already reached or approached maximal levels,  alpha 2 agonists can be administered early in the illness, such as at the first signs of schizophrenic illness, and continuously or intermittently thereafter to prevent the development or worsening of pathological brain changes.
Gill remodeling is an important strategy for fish to cope with hypoxia, and many of the teleost possess this ability, but the underlying mechanism is not well understood. To investigate the mechanism of hypoxia-induced gill remodeling, largemouth bass (Micropterus salmoides) exposed to hypoxia (dissolved oxygen level: 2.0 ± 0.2 mg L-1) for 7 days, followed by 7 days of reoxygenation. Hypoxia tests were also performed on primary gill cells from largemouth bass. We found that hypoxia-induced gill remodeling increased the respiratory surface area of the gills. This change in gill morphology was reversible and recovered after reoxygenation. A reduction in the number of mucous cells and rearrangement of mitochondria-rich cells (MRCs) were observed during gill remodeling. After 7 days of reoxygenation, the number of mucous cells and the position of the MRCs were restored. Hypoxia resulted in a 2.92-fold increase in the number of primary gill cells that underwent migration over a 12-h period. The mRNA levels of nine integrin subunits (α1, α2, α5, α7, α8, α10, αL, β1 and β2) were significantly up-regulated after 12 h of hypoxia in vivo, and the changes in the expression of these subunits were consistent with the HIF-1α trend. Immunohistochemistry showed that integrin β1 protein levels were significantly increased and were abundantly expressed in the interlamellar cell mass after exposure to hypoxia. Taken together, the results of the present study demonstrated that changes in mucosal cells and MRCs play an important role in hypoxia-induced gill remodeling in largemouth bass and that these changes are regulated by integrins.