anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The trial will be conducted in 6000 children in Burkina Faso and Mali in 2008 and 2009. Each site will enroll 3,000 children. All children will be allocated a long lasting insecticide-treated net and randomized to receive to treatment (amodiaquine + sulfadoxine-pyrimethamine (AQ+SP)) or placebo (AQ-placebo + SP-placebo. Treatment will be administered over 3 rounds during the high malaria transmission season, with one month interval between rounds. Full course treatment of AQ and SP will be administered on each occasion. Treatment will not be given in the second year. Passive surveillance of malaria will be implemented for the monitoring of malaria morbidity and to assess whether children who received intermittent preventive treatment (IPT) are at increased risk of malaria. Adverse events will be monitored during each round of IPT administration. To assess the effect of IPTc on the prevalence of malaria infection, a random sample of 150 children will be visited every week during the high malaria transmission period. This number will be increased to 300 during the low transmission season, but the survey will be reduced to monthly visits. Baseline prevalence of genetic markers of resistance to SP and AQ will be estimated. A second cross-sectional survey will be conducted at the end of the malaria transmission season to assess the effect of IPT on the prevalence of genetic markers of resistance to SP and AQ, on the prevalence of anaemia and on nutritional indicators.
The 7th National Audit Project (NAP7) of the Royal College of Anaesthetists studied peri-operative cardiac arrest including those that occurred in the independent healthcare sector, which provides around 1 in 6 NHS-funded care episodes. In total, 174 (39%) of 442 independent hospitals contacted agreed to participate. A survey examining provider preparedness for cardiac arrest had a response rate of 23 (13%), preventing useful analysis. An activity survey with 1912 responses (from a maximum of 45% of participating hospitals) showed that, compared with the NHS caseload, the independent sector caseload was less comorbid, with fewer patients at the extremes of age or who were severely obese, and with a large proportion of elective orthopaedic surgery undertaken during weekday working hours. The survey suggested suboptimal compliance rates with monitoring recommendations. Seventeen reports of independent sector peri-operative cardiac arrest comprised 2% of NAP7 reports and underreporting is likely. These patients were lower risk than NHS cases, reflecting the sector's case mix, but included cases of haemorrhage, anaphylaxis, cardiac arrhythmia and pulmonary embolus. Good and poor quality care were seen, the latter including delayed recognition and treatment of patient deterioration, and poor care delivery. Independent sector outcomes were similar to those in the NHS, though due to the case mix, improved outcomes might be anticipated. Assessment of quality of care was less often favourable for independent sector reports than NHS reports, though assessments were often uncertain, reflecting poor quality reports. Overall, NAP7 is unable to determine whether peri-operative care relating to cardiac arrest is more, equally or less safe than in the NHS.
1,143,545. Water-in-oil emulsions in vaccines. WELLCOME FOUNDATION Ltd. 17 March 1966 [25 March, 1965], No. 12726/65. Heading A5B. An injectable vaccine is a sterile, water-in-oil emulsion, comprising an aqueous antigenic material from at least one pathogenic species of Clostridium, a mineral oil, a lipophilic emulsifier, and a hydrophilic emulsifier. Antigens may be concentrated or unconcentrated, and are derived from one or more of Clostridium perfringens Types B, C and D; Cl. chauvei; Cl. septicum; Cl. oedematiens; and Cl. tetani, by conventional procedures. The antigens may be derived from several such spieces of from single species and then optionally combined to provide multi-component vaccines. Emulsifiers employed are preferably non-ionic; lipophilic emulsifiers suitably being surface active agents having a hydrophile-lipophile balance (HLB) between 2 and 8, such as di- and tri-esters of glycerol and fatty acids; and sorbitol or mannitol anhydride partial esters with fatty acids. Hydrophilic emulsifiers preferably have an HLB value between 9 and 20. and may be polyglycol fatty acid esters; polyoxyethylene modified fatty acid esters; polyoxyethylene-polyol fatty acid esters; polyoxypropylene fatty alcohol ethers; and polypropylene glycol fatty acid esters; such as polyoxy-ethylene derivatives of partial esters of hexitol anhydrides and fatty acids - e.g., various grades of Tween, (Registered Trade Mark). Suitable oils are light liquid paraffins. The emulsions may be stabilised by addition of a material containing beeswax, paraffin oils and lanolin oxy-cholesterins, and may contain a preservative, such as thiomersal. They may be prepared by conventional emulsifying processes, such as mixing of the components with agitation, or by passage through a colloid mill. The components may be sterilised by heating or filtration before admixture, or the final product sterilised with gamma-radiation. The vaccines may be used for prophylaxis of Blackleg, Braxy, pulpy kidney disease, dysentery, and tetanus in sheep or cattle.
PCT No. PCT/JP81/00291 Sec. 371 Date Jun. 9, 1982 Sec. 102(e) Date Jun. 9, 1982 PCT Filed Oct. 19, 1981 PCT Pub. No. WO82/01317 PCT Pub. Date Apr. 29, 1982.A medicinal adhesive sheet for heart diseases having only slight irritation to the skin, which comprises an adhesive composition supported on a suitable base, the composition containing as essential ingredients a copolymer containing dodecyl methacrylate as main monomer component and a suitable amount of nitroglycerin, and the composition having an excellent nitroglycerin-releasing property and a good balance between adhesive strength and cohesive strength.
Interleukins are a diverse group of cytokines that play a crucial role in controlling immune responses and have potential as biomarkers. This mini review evaluates 12 recent papers linking urinary interleukins to both urinary infection and systemic diseases. While measurement of serum interleukins can indicate systemic inflammation, urinary interleukins provide more specific insights into renal or urinary tract inflammation. Urinary interleukins such as IL-8, IL-18, and IL-1β show promise for diagnosing urinary tract infections and other conditions. However, their diagnostic utility is complicated by their wide distribution in the body and patient-related factors. Advances in analytical techniques have enhanced the sensitivity and speed of interleukin measurement, improving their clinical utility. PATIENT SUMMARY: This review highlights research showing that measurement of molecules associated with the immune system in urine samples can help in diagnosing and monitoring disease affecting the urinary tract and kidneys. These urine tests can provide more specific information about infections than blood tests can.
Mindfulness intervention (12 months). Mindfulness based Cognitive Therapy is an evidence-based psychological program designed to help manage depressive and stress symptoms.
Continued salvage radiotherapy as initially planned (to 70.0 Gy/73.5 Gy in 35 fractions to the prostate bed/local recurrence if present). These patients are classified as responders according to weekly PSA measurements during the first 4 weeks of radiotherapy, and are not followed according to the study protocol, follow up according to clinical practice.
People with moderate to severe chronic obstructive pulmonary disease (COPD) experience intense symptoms of dyspnea when they use their arms and shoulders. To control dyspnea they avoid using their arms and ultimately experience a significant loss of upper body (UB) strength and a decrease in the level of physical activity. Some pulmonary rehabilitation programs include strength training, but the training intensity is typically very low. The purpose of this research is to examine the effects of UB strength training (designed to maximize strength gains) with a self-confidence intervention to enhance adherence to exercise. This is an experimental study with random assignment of subjects to one experimental and two control groups: (a) UB strength training and self-efficacy intervention for adherence (experimental), (b) UB strength training with health education (control 1) and (c) gentle armchair fitness exercises with health education (control 2). Each subject will be studied for a total of 16 months.The intervention period is four months in duration with a 12-month follow-up period. The sample will be people with moderate to severe COPD who experience dyspnea with UB activities. This research is innovative in that it examines the effects of upper body strength training designed to maximize strength gains and combines it with a theory-based self-efficacy (confidence-building) intervention to promote adherence to training in people with COPD.
FIELD: medicine, organic chemistry. SUBSTANCE: desired product is prepared by interaction of 2-mercapto-4-phenyl imidazole and hydrobromide of 2-morpholinoethyl bromide. The process is carried out in the medium of NaOH. Thus obtained product is mixed with isopropanol, then HCl and ether are added. Yield of desired product is 62.6 %, its melting point being 246 C. EFFECT: improves quality of desired product. 1 tbl
Subarachnoid hemorrhage due to rupture of intracranial aneurysms has a poor outcome, making this disease being the social problem. Inflammation evoked by the increase in intracranial pressure and the clot in the subarachnoid space after the onset of SAH exacerbates neuronal death and vasospasm, resulting in the poor outcome and severe aftereffects. Here, FROUNT mediates CCR2 and CCR5 signaling as an intracellular molecule binding to these chemoattractant receptors which facilitate the migration of inflammatory cells, such as macrophages, in situ to trigger inflammation there. Animal model of subarachnoid hemorrhage was established in rats through intrathecal injection of autologous blood. The effect of the FROUNT inhibitor, disulfiram, on survival rate, neuronal death in hippocampus or vasospasm was then examined. The intrathecal administration of disulfiram significantly suppressed the infiltration of CD68-positive macrophages and myeloperoxidase-positive neutrophils toward the clot in the cistern in situ. In this condition, disulfiram ameliorated the death of animals after the onset of subarachnoid hemorrhage in rats. In addition, disulfiram suppressed both the two major events after subarachnoid hemorrhage, the neuronal death in hippocampus and vasospasm. The pharmacological inhibition of CCR2 and CCR5 signaling by disulfiram could thus be the therapeutic strategy to improve the outcome of subarachnoid hemorrhage.
An composition for application to a disordered tissue, the composition including an antipathogenic agent, a healing agent and an optional soothing agent. The antipathogenic agent can include cineole, and the healing agent can include an amino acid such as L-arginine or L-carnosine. The cineole can be of dual function, for example, it can operate as an antipathogenic agent, and also operate to enhance penetration of at least one of the antipathogenic agent, healing agent and/or soothing agent into the disordered tissue, which can be skin of a subject. The disordered tissue can be afflicted by an infection, for example, a Type I herpes infection, and can be in the form of a cold sore. The composition can be in a form, such as a cream or a lip balm, adapted for topical application to the disordered tissue. A method for treating the disordered tissue with the composition is also provided.
This phase IIb study is a prospective, single-blind, parallel, active-controlled study to evaluate the efficacy and safety of Chondrochymal® in subjects with knee OA. All the subjects will be enrolled in Taiwan. The target population is composed of subjects with unilateral or bilateral OA knee(s). For subjects with bilateral OA knees, only the knee with more severe symptoms will be selected as the target knee. If the severities of the OA symptoms are the same for both knees, the knee with more pain should be selected, where the WOMAC pain score will take the priority over the VAS index. Eligible subjects will be randomized into one of the study groups, Chondrochymal® Group or Control Group, in 1:1 ratio. To keep the blindness, the subject's eyesight will be masked by a curtain while receiving the IA injection.
Subjects with neuroendocrine prostate cancer (NEPC). Avelumab will be administered intravenously at a dose of 10 mg/kg every 2 weeks.
<P>PROBLEM TO BE SOLVED: To obtain a textile material having a sufficient amount of minus ion generated and to provide a method for producing the same.  <P>SOLUTION: (1) The textile material comprises a minus ion generating body which is stuck fast through a positively charging binder resin to at least one side of a fabric. (2) The textile material comprises the minus ion generating body which is stuck fast through a binder resin to at least one side of a fabric having an antistatic layer. (3) The textile material comprises the minus ion generating body stuck fast through the binder resin to at least one side of the fabric in which the thickness of a binder resin layer containing the binder resin is ≥1 μm. (4) The textile material comprises the minus ion generating body stuck fast through the positively charging binder resin to at least one side of the fabric having the antistatic layer. (5) Minus ion having beneficial effect on the human body is surely generated by the textile material comprising a slit yarn obtained by slitting the above-mentioned textile material.  <P>COPYRIGHT: (C)2004,JPO
The present invention provides a pharmaceutical composition, a patch and a manufacturing method thereof, an analgesic method, and an application. The pharmaceutical composition comprises a single anesthetic active ingredient. The anesthetic active ingredient comprises a water-dissolving anesthetic active ingredient and an anesthetic active ingredient existing in an insoluble form. The mass percent content of the anesthetic active ingredient in the pharmaceutical composition is 2% or more. The mass percent content of the water-dissolving anesthetic active ingredient in the pharmaceutical composition is 1% or less. The anesthetic active ingredient comprises lidocaine, tetracaine, bupivacaine, articaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, mepivacaine, prilocaine, ropivacaine, trimecaine, benzocaine or procaine. The pharmaceutical composition and the patch can provide continuous analgesia for 12-30 hours. The patch is resistant to a certain amount of external squeezing force, preventing a formulation layer covered by the same from being squeezed out, thereby maintaining the thickness of the formulation layer.
Basal like breast carcinoma is a Her2, ER PR negative breast cancer. It is notable for the high percentage of EGFR expression in this tumor subtype.Weekly taxol (paclitaxel) is widely used in breast cancer patients with metastatic disease. Erbitux (cetuximab) is a monoclonal antibody that shown its ability to enhance activity of chemotherapy in colon carcinoma. Thus we wanted to combine the use of anti EGFR therapy in the form of Erbitux (cetuximab) with the widely used weekly taxol chemotherapy for the treatment of women with basal like breast carcinoma. This is a small phase II study that will hopefully provide initial data as to the general tolerability and response rate of this combination in this disease. Furthermore, pathologic analysis will be used to try and assess relation of response with the presence of immunohistochemical markers such as EGFR expression.
The invention belongs to the technical field of medicines, and relates to sialic acid modified dexamethasone palmitate liposome, and a preparation method and application thereof. The sialic acid derivative modified dexamethasone palmitate liposome disclosed by the invention comprises sialic acid derivatives, phospholipids, cholesterol and dexamethasone palmitate. The sialic acid derivative is selected from one of sialic acid-cholesterol, sialic acid-stearic acid, sialic acid-2- (hexadecyloxy) acetic acid or sialic acid-2- (octadecyloxy) acetic acid. In the sialic acid derivative modified dexamethasone palmitate liposome, the sialic acid derivative accounts for 1% -50% of the total weight of the liposome, and is preferably 10-30%. Wherein, the phospholipid is 50-90%; cholesterol is 0-40%; dexamethasone palmitate 5-20%. The sialic acid can improve the in-vitro and in-vivo cell targeting of the liposome.
An exemplary embodiment provides an explanation and interpretation generation system for creating explanations in different human and machine-readable formats from an explainable and/or interpretable machine learning model. An extensible explanation architecture may allow for seamless third-party integration. Explanation scaffolding may be implemented for generating domain specific explanations, while interpretation scaffolding may facilitate the generation of domain and scenario specific interpretations. An exemplary explanation filter interpretation model may provide an explanation and interpretation generation system optional filtering and interpretation filtering and briefing capabilities. An embodiment may cluster explanations into concepts to incorporate information such as taxonomies, ontologies, causal models, statistical hypotheses, data quality controls, domain specific knowledge and allow for collaborative human knowledge injection. An embodiment may include a flexible presentation layer, user model and a goal-plan-action system to enable practical and useful actionable explanations to be generated.
OBJECTIVES: At present, there are many limitations in the evaluation of lymph node metastasis of lung adenocarcinoma. Currently, there is a demand for a safe and accurate method to predict lymph node metastasis of lung cancer. In this study, radiomics was used to accurately predict the lymph node status of lung adenocarcinoma patients based on contrast-enhanced CT.
METHODS: A total of 503 cases that fulfilled the analysis requirements were gathered from two distinct hospitals. Among these, 287 patients exhibited lymph node metastasis (LNM +) while 216 patients were confirmed to be without lymph node metastasis (LNM-). Using both traditional and deep learning methods, 22,318 features were extracted from the segmented images of each patient's enhanced CT. Then, the spearman test and the least absolute shrinkage and selection operator were used to effectively reduce the dimension of the feature data, enabling us to focus on the most pertinent features and enhance the overall analysis. Finally, the classification model of lung adenocarcinoma lymph node metastasis was constructed by machine learning algorithm. The Accuracy, AUC, Specificity, Precision, Recall and F1 were used to evaluate the efficiency of the model.
RESULTS: By incorporating a comprehensively selected set of features, the extreme gradient boosting method (XGBoost) effectively distinguished the status of lymph nodes in patients with lung adenocarcinoma. The Accuracy, AUC, Specificity, Precision, Recall and F1 of the prediction model performance on the external test set were 0.765, 0.845, 0.705, 0.784, 0.811 and 0.797, respectively. Moreover, the decision curve analysis, calibration curve and confusion matrix of the model on the external test set all indicated the stability and accuracy of the model.
CONCLUSIONS: Leveraging enhanced CT images, our study introduces a noninvasive classification prediction model based on the extreme gradient boosting method. This approach exhibits remarkable precision in identifying the lymph node status of lung adenocarcinoma patients, offering a safe and accurate alternative to invasive procedures. By providing clinicians with a reliable tool for diagnosing and assessing disease progression, our method holds the potential to significantly improve patient outcomes and enhance the overall quality of clinical practice.
Continuous positive airway pressure (CPAP) for the treatment of moderate obstructive sleep apnea (OSA) is only reimbursed in Belgium after in-laboratory overnight titration. Nevertheless, in a recent clinical practice guideline of the AASM, it is recommended that PAP therapy can be initiated using either in-laboratory titration or auto-titrating CPAP (APAP) at home in OSA patients without significant comorbidities. Indeed, several studies evaluated the impact of titration with APAP at home in these patients and showed that the outcome is comparable with in-hospital titration. Up to now, evidence for home titration with fixed CPAP (and follow-up via telemonitoring) is very limited. The use of sleep laboratory space is costly and limits access for diagnostic studies. This study aims to evaluate whether CPAP titration at home with fixed CPAP produces outcomes equal to those following APAP titration.
Research findings show that genetic susceptibility to sporadic Parkinson's disease (PD), a common neurodegenerative disorder, is determined through gene variation of loci involved in its development and pathogenesis. A growing body of strong evidence has revealed that dysfunction of long non-coding RNAs (lncRNAs) plays key roles in the pathogenesis and progression of PD through impairing neuronal signaling pathways, but little is known about the relationship between their variants and PD susceptibility. In this research, we intended to study the relationship between functional SNPs rs12826786C>T, rs3200401C>T, and rs6931097G>A in the key lncRNAs stimulating neuroapoptosis and neuroinflammation in PD, including HOTAIR, MALAT1, and lincRNA-P21, respectively, with susceptibility to PD as well as its clinical symptoms.The population of this study consisted of 240 individuals, including 120 controls and 120 cases, and the sample taken from them was peripheral blood. Genotyping of the target SNPs was done using PCR-RFLP. We found that the healthy individuals carry more T allele of MALAT1-rs3200401C>T compared to the patients (P= 0.019). Furthermore, it was observed that in the dominant genetic model, subjects with genotypes carrying the T allele have a lower risk of PD (OR= 0.530; CI= 0.296-0.950; P= 0.033). Regarding the lincRNA-P21-rs6931097G>A, we observed a significant protective relationship between its GA (OR= 0.144; CI= 0.030-0.680; P= 0.014) and AA (OR= 0.195; CI= 00.047-0.799; P= 0.023) genotypes with the manifestation of tremor and bradykinesia symptoms, respectively. Furthermore, the findings indicated that the minor TT genotype of HOTAIR-rs12826786C>T was significantly associated with a reduced risk of bradykinesia symptoms (OR= 0.147; CI= 0.039-0.555; P= 0.005). Collectively, these findings suggest that MALAT1-rs3200401C>T may be an important lncRNA SNP against the development of PD, while the other two SNPs show protective effects on the clinical manifestations of PD in a way that lincRNA-P21-rs6931097G>A has a protective effect against the occurrence of tremor and bradykinesia symptoms in PD patients, and HOTAIR -rs12826786C>T indicates a protective effect against the display of bradykinesia feature. Therefore, they can have valuable potential as biomarkers for clinical evaluations of this disease.
Clinical pharmacists will be trained by a team with expertise in behavioral and HIV clinical care, and participate in a 10-hour training course with coaching sessions offered over the course of the study to ensure effective and consistent performance. Pharmacists will be guided by a manual designed to provide and walk them through the necessary skills to perform the pilot intervention easily and effectively. The manual will provide background information, study goals, and describe the critical components of the IMB-MI model and the HARP pilot interventions. An easy to follow, step-by-step approach to performing the intervention will be included. The study protocol to be followed by the clinical pharmacists will be included in the manual along with additional motivational and troubleshooting strategies. Systematic feedback regarding intervention fidelity will be provided by the Evaluation Team.