anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a perfume composition having clearly soft persistent musk or nitro musk characteristics and can act as a fixative, especially a perfume well-balanced between gentleness and initial order intensity by using a macrocyclic lactone. SOLUTION: Compounds of formulas I and/or II [wherein R is H or methyl; and the broken line is an additional bond in position 11 or 12] are used as perfumes. A lactone I of formula I and a lactone II of formula II are obtained by Claisen rearrangement or the thermal or photochemical fragmentation of tetrahedron and a peroxide or another derivative by a metathesis reaction over e.g. a nickel catalyst. Particularly, in preparing a composition by using a macrocyclic lactone such as 11-cistetradecene-14,1-olide into a composition, it is used in an amount of 8-15wt.% based on the composition. This composition is used in an amount 1-5wt.% based on the substrate to prepare perfumes or to impart perfume to cosmetics, disinfectants, textile finishes, etc.
PURPOSE: A composition containing morin for protecting from radiation is provided to remove oxygen radical and to suppress DNA damage without toxicity. CONSTITUTION: A composition for protecting from radiation contains morin compound of chemical formula or salt thereof as an active ingredient. The radiation is gamma radiation. A drug for protecting from radiation contains the composition containing morin compounds. A functional food for protecting from radiation contains the morin-containing composition. The food is yogurt, bread, drink, chewing gum, candy, biscuit, ice cream, or chocolate.
Intentional insulin omission for weight control is a significant problem in the clinical management of type 1 diabetes (T1D); despite this, there are no effective treatments. Combining the use of mobile technology with individual therapy may help individuals with T1D identify their triggers for insulin omission in their natural environment and cope more effectively. In the current study, the investigators examine whether pairing a mobile application, Recovery Record, with individual therapy helps reduce intentional insulin omission for weight control among individuals with T1D. In Phase 1, the investigators build T1D-specific content into the Recovery Record app based on our empirical evidence of triggers for insulin omission and qualitative feedback from T1D patients. The fully functional app is beta tested with 10 T1D patients who intentionally omit insulin. In Phase 2, 25 T1D patients that misuse insulin complete 3 months of app-supported individual treatment and 6 months of follow-up. The investigators test whether treatment is associated with decreases in mean blood glucose, eating disorder symptoms and emergency care utilization. The investigators also test whether frequency of app use in months 0-3 corresponds with outcomes, and calculate attrition..
Embodiments include colorant compositions that are water-based and gloss compositions. Certain liquid lip color embodiments include a composition having water and shellac. The composition may also include a neutralizer such as triethanolamine to neutralize the shellac. The composition may also include PPG-17/IPDI/DMPA copolymer. The composition may also include an emulsifier such as acrylates/acrylamide copolymer and mineral oil and polysorbate 85. In addition, the composition may also include a colorant. Embodiments also include gloss compositions including polybutene, polyethylene, and shea butter. Other ingredients may also be present in the liquid lip color and the gloss compositions. Other embodiments are described and claimed.
A Dynamic Multi-Sensory Simulation System for effecting behavior change includes a user interface and a sensor array for presenting information to a user and collecting biometrics from the user. The information and biometrics may be stored on a local computer or may be transmitted to and from a remote computer via a network. The remote computer may include a remote biometrics service and a dynamic experience engine. The remote biometrics service is operable to interpret biometic data signals representative of a users biological or physiological state. The dynamic experience engine is operable to present content to a user based on a user reaching a desired biological or physiological state as determined by the remote biometics services. The remote computer may also comprise a first database and a second database.
Patients receive placebo PO BID on days 1-56. Treatment continues in the absence of disease progression or unacceptable toxicity.
A system for creating a personalized patient pathway is described. An initial patient pathway obtainer (1) is used for obtaining an initial patient pathway for a patient. A constraints obtainer (2) is applied for obtaining a set of constraints (7)on the patient pathway. A change indication module (3) is used for enabling a user to indicate a change to the patient pathway. A patient pathway updater (4) serves for generating an updated patient pathway (8), based on the initial patient pathway, the indication of the change, and the set of constraints (7). The initial patient pathway obtainer (1) is arranged for generating the initial patient pathway,based on a clinical guideline (5) and/or a patient parameter (6).
All participants will complete baseline sessions: 1) sub-maximal exercise test to ensure safe participation in aerobic exercise (testing session \[s\] 1); and 2) magnetic resonance imaging (MRI) to assess brain structure and function, and 3) clinical assessments of motor function and activity. The MRI and clinical tests will be completed on s2. Between the exercise test and MRI sessions individuals will wear accelerometers for 3 days to index usual activity levels. A custom computer program will then assign participants quasi-randomly to either the rest or exercise groups stratified on age, sex, and baseline motor function. Cortical excitability will be assessed before and after either a single session of priming aerobic exercise, or rest, by group (s3). Next, priming exercise will be paired with skilled motor practice for 5 sessions (s4-8). Practice sessions will be separated by 48 hours. Importantly motor learning will be assessed via delayed, no-exercise retention tests 24-hours (s9) and 30-days (s11) after the last practice session. Activity levels (3 day accelerometry), TMS and MRI measures will be re-assessed after the second retention test (s10).
The purpose of this study is to determine if a simple random cluster intervention trial to improve hand hygiene, consisting of a 3-4 minute training video, on-site posters, and hand hygiene supplies, can reduce respiratory and GI illness among those in the intervention group compared to the control group. The intervention was performed among employees in a Midwestern public government setting. Employees in the treatment group received a 3-4 minute training video online that was embedded in the baseline survey. Motivational posters from the USDHHS encouraging proper hand hygiene were installed in the workplace, along with hand hygiene supplies. The control group received a program called "Ask Me 3" developed by the National Patient Safety Foundation; the intervention consisted of a 3-4 minute training video to encourage clear communication with their health care providers, a brochure discussing the Ask Me 3 principles of clear communication with health care providers, and a key-ring with the Ask Me 3 communication principles to promote more effective communication with health care providers at visits out side of work. The groups were followed monthly through surveys over the Internet for an average of three months after baseline to determine if a relative reduction in self-reported respiratory / GI infections occurred in the intervention group compared to the control group.
###  Teratogenic Effects

####  Pregnancy Category B

There has been no experience to date with the use of Metronidazole Vaginal Gel in pregnant patients. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to pregnant mice at six times the recommended human dose (based on mg/m2); however, in a single small study where the drug was administered intraperitoneally, some intrauterine deaths were observed. The relationship of these findings to the drug is unknown.

There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, and because metronidazole is a carcinogen in rodents, this drug should be used during pregnancy only if clearly needed.
Artificial threads, ribbons, tubes, capsules, pills, or plugs of cellulose or its organic derivatives, or mixtures thereof with polyvinyl compounds, are rendered capable of resorbtion by incorporating therein before, during or after manufacture, oxalic acid, malic acid, an amino acid such as glycocoll or asparaginic acid, or phenylhydrazine hydrochloride.  The substance promoting resorbtion may be added to the spinning solution, or emulsified in the softened cellulose, or incorporated in the formed thread &c. by impregnation.  The strength of the threads may be increased by the incorporation of sulphocyanides and cane sugar.  Bactericidal substances, e.g. propyl benzoate and metal compounds or esters of organic acids may be incorporated; also therapeutically active substances.  Specifications 393,505 and 427,106 are referred to.ALSO:Artificial threads, ribbons, tubes, capsules, pills, or plugs of cellulose or its organic derivatives, or mixtures thereof with polyvinyl compounds, are rendered capable of resorption by incorporating therein, before, during or after manufacture, oxalic acid, malic acid, an amino acid such as glycocoll or asparaginic acid, or phenylhydrazine hydrochloride.  The substance promoting resorption may be added to the spinning solution, or emulsified in the softened cellulose, or incorporated in the formed thread &c. by impregnation.  The strength of the threads may be increased by the incorporation of sulphocyanides and cane sugar. Bactericidal substances, e.g. propyl benzoate and metal compounds or esters of organic acids may be incorporated; also thereapeutically active substances.  Specifications 393,505, [Group IV], and 427,106 are referred to.
Therapeutic exercise is important to patients with knee osteoarthritis. Few studies reported the effect of therapeutic exercise in proprioception for these patients. The purposes of this study were to investigate the train-ing effect of sling suspension exercises, as a proprioception-training tool, for patients with knee osteoarthritis and further, to build up an model of proprioception training. Twelve subjects were recruited in this study. The inclusion criteria were aged 50 to 70, both genders, diagnosed as knee osteoarthritis, grading 2 or 3 in Kellgren's scale. After having their consents all subjects received baseline measurements including active joint reposition test, functional ambulating test and self-evaluating with Western Ontario \& McMaster Universities Arthritis Index (WOMAC). Then they were randomly assigned to training group and reference group. Seven subjects in the training group received the treatment of heat, interferential current (IFC), and sling suspension exercises or just only sling suspension exercises. Five subjects in the reference group received the treatment of heat and IFC or no intervention. The training sessions of sling suspension exercises were 3 times per week, lasting for8 weeks. After 8-week training, both groups were given post-test which is completely the same as pre-test. Mann-Whitney U Test was used to test the difference between groups, and Wilcoxon Signed Ranks Test was used to test pre-post difference in both groups. The results showed it was no difference between both groups in all the measurements of pre-test. After 8 weeks, it showed significant difference on joint reposi-tion test (p\<.05) but no difference on functional ambulating test and WOMAC index (p\>.05) between the 2 groups. In the training group, all mea-surements got significant improvement (p\<.05) except one of the functional ambulating tests. However, the reference group only showed significant improvement in pain and physical function subscales of WOMAC (p\<.05). This study concludes that the sling suspension exercises designed for patients with knee osteoarthritis improve the proprioception of knee joint. The con-tent and concept of sling suspension exercises in this study might be a refer-ence of proprioception training for patients with knee osteoarthritis. Increasing case number and elongating the duration of intervention are suggested in further studies.
PURPOSE:To provide a cosmetic compounded with a phototropic inorganic compound and/or a composite material containing said inorganic compound and forming a treated skin giving natural and beautiful appearance under any light condition. CONSTITUTION:The objective cosmetic contains 0.5-99wt% (preferably 5-99wt%) phototropic inorganic compound changing its color upon irradiation with light and returning to the original color by stopping the irradiation and/or a composite material containing said inorganic compound. Since the cosmetic is blackened by sunlight, the dressed skin color in room has little difference from the color under sunlight. The cosmetic has excellent color rendering properties, stability and safety. The above inorganic compound is e.g. a metal oxide (e.g. titanium oxide, niobium oxide, etc.), hydrate of metal oxide (e.g. hydrated titanium oxide), a composite of metal oxide and metal hydrate, ZnS, Hg3S2I2, etc.
The evidence for the efficacy of colchicine in patients with FMF is derived from the published literature. Three randomized, placebo-controlled studies were identified. The three placebo-controlled studies randomized a total of 48 adult patients diagnosed with FMF and reported similar efficacy endpoints as well as inclusion and exclusion criteria.

  


One of the studies randomized 15 patients with FMF to a six month crossover study during which five patients discontinued due to study noncompliance. The ten patients completing the study experienced five attacks over the course of 90 days while treated with colchicine compared to 59 attacks over the course of 90 days while treated with placebo. Similarly, the second study randomized 22 patients with FMF to a four month crossover study during which nine patients discontinued due to lack of efficacy while receiving placebo or study noncompliance. The 13 patients completing the study experienced 18 attacks over the course of 60 days while treated with colchicine compared to 68 attacks over the course of 60 days while treated with placebo. The third study was discontinued after an interim analysis of six of the 11 patients enrolled had completed the study; results could not be confirmed.

  


Open-label experience with colchicine in adults and children with FMF is consistent with the randomized, controlled trial experience and was utilized to support information on the safety profile of colchicine and for dosing recommendations.
Inflammatory response to aggressive infection is responsible not only for symptoms, especially pain, but also for severity, when the inflammatory cascade is violent, and provokes a deleterious cytokine storm. Due to their anti-inflammatory properties, corticosteroids are widely used in ambulatory medical practice. While their beneficial effects on some symptoms, particularly pain, are undeniable, so are the risks associated with their other properties (immunosuppression, neurostimulation, hypermetabolism), even during short-term administration at low doses. Following robust risk-benefit assessment, the role of corticosteroids in the treatment of a number of serious pathologies (septic shock, severe acute community-acquired pneumonia, and some forms of bacterial meningitis such as hypoxia-related pneumocystosis, etc.) is presently well-defined. The objective of this review is not to consider the role of corticosteroids in cases of severe infectious disease necessitating hospital-based management, or in contexts where there exists a clear consensus in favor of their utilization. This work represents an attempt to apprise the current state of knowledge on the interest of corticosteroids in the management of infections in adults in primary care. Corticosteroid treatment can be beneficial with regard to some of the infectious diseases treated in primary care. That said, when the benefit actually appears, it remains modest, and the level of evidence supporting the utilization of corticosteroids is low or moderate. In no situation is an indication for corticosteroid therapy official or even, at the very least, indisputable. With regard to the pathologies under consideration, corticosteroid prescription must imperatively be based on impeccable characterization of the clinical situation, diagnosis of severity, knowledge of the disease field, and risk-benefit assessment for a given patient.
There is growing interest in the role of prehabilitation to reduce surgical risk, attenuate surgery-related deconditioning, and facilitate postoperative recovery. Compared to the postoperative setting, initiating health interventions preoperatively is proposed as an important strategy to improve health outcomes because: i) it targets modifiable risk factors for surgical complications; ii) patients may be more physically and/or psychologically capable of affecting change in health status compared to the early postoperative period; iii) wait times prior to surgery may be several weeks thus representing an opportunity to proactively invest in their recovery; and iv) patients may be sensitized to the importance of adverse health behaviours that may have contributed to the need for surgery (i.e. a 'teachable moment'). The potential benefit of prehabilitation extends beyond potential gains in health from baseline to surgery, but also includes the prevention or attenuation of deconditioning that patients experience during the postoperative period. The findings of recent systematic reviews and meta-analyses assessing the benefits of prehabilitation interventions in surgical patients provide support for their efficacy in improving physical fitness, length of stay, surgical complication rates, and health-related quality of life (HRQOL).

While previous interventional studies have demonstrated promising findings, little is known about how feasible it is to integrate prehabilitation into standard of care for people awaiting surgery. This study intends to employ intervention design features previously shown to be feasible and efficacious and employs a hybrid effectiveness-implementation trial design model to assess feasibility of clinical integration.
INTRODUCTION: Stunting is still a major public health problem all over the world, it affecting more than one-third of under-five children in the world that leads to growth retardation, life-threatening complication and accelerate mortality and morbidity. The evidence is scarce on prevalence and associated factors of stunting among under-five children in Sub-Saharan Africa for incorporated intervention. Therefore this study aimed to investigate the prevalence and determinants of stunting among under-five children in Sub-Saharan Africa using recent demographic and health surveys of each country.
METHODS: This study was based on the most recent Demographic and Health Survey data of 36 sub-Saharan African countries. A total of 203,852(weighted sample) under-five children were included in the analysis. The multi-level ordinal logistic regression was fitted to identify determinants of stunting. Parallel line (proportional odds) assumption was cheeked by Brant test and it is satisfied (p-value = 0.68) which is greater than 0.05. Due to the nested nature of the dataset deviance was used model comparison rather than AIC and BIC. Finally the adjusted odds ratio (AOR) with 95% CI was reported identify statistical significant determinants of stunting among under-five children.
RESULTS: In this study, the prevalence of stunting among under-five children in Sub-Saharan Africa 34.04% (95% CI: 33.83%, 34.24%) with a large difference between specific countries which ranges from 16.14% in Gabon to 56.17% in Burundi. In the multi-level ordinal logistic regression good maternal education, born from mothers aged above 35 years, high household wealth status, small family size, being female child, being female household head, having media exposure and having consecutive ANC visit were significantly associated with lower odds of stunting. Whereas, living from rural residence, being 24-59 month children age, single or divorced marital status, higher birth order and having diarrhea in the last two weeks were significantly associated with higher odds of stunting.
CONCLUSION: Stunting among under-five children is still public health problem in Sub-Saharan Africa. Therefore designing interventions to address diarrhea and other infectious disease, improving the literacy level of the area and increase the economic level of the family to reduce the prevalence of stunting in the study area.
Herein, we report a rare case of arterial cerebral air embolism (aCAE), that was probably caused by aspiration pneumonia. An 84-year-old-male presented with sudden loss of consciousness. Computed tomography (CT) of the head revealed air shadows along the sulcus of the right frontal and left posterior lobes. The abdominothoracic CT revealed aspiration pneumonia in the right upper lung with cavity formation. His clinical symptoms lessened after the administration of an antiepileptic. Because there was no prior history of any medical treatment, the patient was diagnosed with a noniatrogenic aCAE. Furthermore, in the absence of a right-to-left shunt, we determined that the air embolization was caused by the aspiration pneumonia. aCAE is a rare disease that can lead to miserable conditions. Most of causes aCAE are iatrogenic. However, a few cases of noniatrogenic aCAE have been reported. Some reports have suggested an associated between iatrogenic aCAE and raised intrathoracic pressure, which could lead to air entry into the pulmonary vein via the damaged alveolar wall. Even in noniatrogenic aCAEs, a sudden increase in intrathoracic pressure may cause airflow via the alveolar wall into the pulmonary veins, resulting in aCAE.
In a cardiovascular outcomes trial enrolling participants with established ASCVD or multiple risk factors for ASCVD (SAVOR trial), more patients randomized to saxagliptin (289/8280, 3.5%) were hospitalized for heart failure compared to patients randomized to placebo (228/8212, 2.8%). In a time-to-first-event analysis the risk of hospitalization for heart failure was higher in the saxagliptin group (estimated Hazard Ratio: 1.27; 95% CI: 1.07, 1.51). Patients with a prior history of heart failure and patients with renal impairment had a higher risk for hospitalization for heart failure, irrespective of treatment assignment. 

Consider the risks and benefits of KOMBIGLYZE XR prior to initiating treatment in patients at a higher risk for heart failure. Observe patients for signs and symptoms of heart failure during therapy. Advise patients of the characteristic symptoms of heart failure, and to immediately report such symptoms. If heart failure develops, evaluate and manage according to current standards of care and consider discontinuation of KOMBIGLYZE XR.