anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A home exercise program consisting of rotator cuff and scapular muscle training will be performed during 6 weeks (4 sessions/week). To monitor progress and control load progression, a physical therapist will visit the subject every week.
A hand hygiene monitoring system is provided. The system includes a wearable tag device coupled to a user, and a reader device communicably coupled to the wearable tag device. The reader device is configured to detect a presence of the wearable tag device by receiving a first frequency message comprising a user identifier from the wearable tag device. The reader device is further configured to transmit a second frequency message to the wearable tag device requesting event log data. The second frequency has a higher frequency than the first frequency. The reader device is further configured to receive an event log data message from the wearable tag device at the second frequency, and to determine whether the wearable tag device has logged a wash station encounter within a configurable time period based on the event log data message.
A group of parents and their children will participate in this single arm, pre-/post-intervention study. This 10-week study will include 10 sets of parents of low-reading elementary school children, recruited from Harlem Grown Community Center. Intervention will be implemented in a 9-week period, with data collection during the first intervention week and one week post-intervention. Three large-group sessions will be held in a central location (at Harlem Grown Community Center), to build community and rapport among researchers and participants. Six individual sessions will take place in the participants' homes, to customize reading strategies and routines to each family's home setting and personal interests. The reading program will help parents identify strategies to establish literacy routines with their children, and to engage with them in enjoyable literacy activities that promote skill building while reducing negative feelings associated with reading.
FIELD: medicamental forms. SUBSTANCE: liquid-powder mixtures are powder-like compositions of liquid drugs possessing acceptable fluidity and compressibility. According to conception of liquid-powder systems, liquid lipophilic drugs or water-insoluble drugs dissolved in appropriate nonvolatile solvents can be transformed into fluid and easily compressed powders by merely mixing them with suitable powdered fillers (carriers) and coating materials. This operation may be schematically represented as a combination of process steps. As carrier, microcrystalline or amorphous cellulose of various types can be utilized and, as coating material, fine silica powders. Based on theoretical idea assuming that carrying substance and coating material are able to only retain certain amounts of a liquid while simultaneously preserving acceptable fluidity and compressibility characteristics, a novel mathematical model is proposed concerning formulation of drug forms in order to enable calculating optimal quantities of carrying substance and coating material needed for preparing title liquid-powder mixture. EFFECT: simplified formulation of drugs. 8 cl, 9 dwg, 11 tbl
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparations of ranolazine. The ranolazine preparation of prolonged effect contains uniform mixture of ranolazine and partially neutralized pH-dependent binding substance for a film formation that is insoluble in an aqueous medium usually at pH below 4.5 but it is soluble in an aqueous medium at pH above 4.5. Preparation is useful for administration of ralonazine, 2 times per a day, and can be used for maintaining ranolazine levels in human blood plasma between its concentration 350 and 7 500 ng/ml. Invention provides the development of medicinal form of prolonged effect and maintenance the preparation concentrations for at least 24 h. EFFECT: valuable medicinal and pharmaceutical properties of preparation. 20 cl, 9 tbl
PURPOSE:A hypotensive agent containing an (omega-piperazinylalkoxy)alkylenedioxybenzene or an acid addition salt thereof as an active constituent, capable of rapidly developing the drug effect, and having prolonged action with low acute toxicity. CONSTITUTION:A hypotensive agent containing a compound of formula I (m is an integer 1-3; n is an integer 2-6; R is pyridyl, pyrazinyl, pyrimidinyl or pyridazinyl) or an acid addition salt thereof as an active constituent in an amount of 0.5-20wt% for an injection and 0.5-10wt% for a solution in the oral administration. The daily dose thereof is 0.1-100mg/kg body weight administered once or more times. The compound of formula I , e.g. 5-{2-[4-(2-pyridyl)-1-piperazinyl]ethoxy}-1,3-benzodioxole, is obtained by reacting a compound of formula II(X is halogen) with a compound of formula III preferably in an inert solvent, e.g. water or dioxane, at room temperature -150 deg.C.
This study is a prospective, multicenter, two-by-two factorial randomized controlled trial evaluating the efficacy of immunonutrition supplementation and oral chlorhexidine decontamination. Patients aged 65 years and older who are scheduled for elective non-cardiac surgeries will be recruited. Participants will be excluded if they have contraindication to the intervention. The patients will be randomized into four groups in 1:1:1:1 ratio (oral decontamination vs routine oral care, immunonutrition supplementation vs routine nutrition advice). The primary outcome is the incidence of postoperative pulmonary complications within 7 days after surgery. Secondary outcomes include incidence of pneumonia, infectious complications, comprehensive complication index, postoperative functional recovery, length of hospital stay and hospital expense.
PURPOSE:To accurately reproduce the image of roentgenoscopy because a roentgenoparent image is effectively stored and kept with a roentgenographic image by recording and displaying the roentgenoparent image with the roentgenographic image. CONSTITUTION:Usually, the roentgenoparent image is used for monitoring and continuously recorded in a digital VTR 10. At the time of generating the roentgenographic image, said image is recorded in the VTR 10 instead of the roentgenoparent image in the same system as a moving picture after performing buffering and dividing into blocks by an input image buffer 8 in order to adjust the roentgenographic image to the recording system of the VTR 10. At such a time, an identification code is added with a retrieval ID. At the time of reproducing the image, a reproduction control part 11 retrieves and reads the image data from the VTR 10 according to the retrieval and display systems of the image designated by an integration control part 5. The kind of image is transferred to buffers 15 and 13 by a code recognition part 12 and displayed on devices 14 and 16. It is transmitted to a printer 17 to form a film 18 when required.
Placebo, oral, tablet, across 3 migraine attacks (1st, 2nd, and 4th). Telcagepant 140 mg will be administered for the 3rd migraine attack. Participants will receive placebo for the optional second dose. For migraine attacks 2, 3, and 4, no study medication will be provided as an optional second dose.
The invention discloses a small molecular peptide and application thereof in preparation of xanthine oxidase inhibitors, belonging to the technical field of bioactive peptides. The amino acid sequence of the small molecule peptide is YHFKIF or YHYKIF, and is shown as SEQ ID NO.3 or SEQ ID NO. 4. The application of the small molecule peptide in preparing xanthine oxidase inhibitor. The small molecular peptides YHFKIF, YHYKIF and YHWKIW have higher XO inhibition activity, are obviously superior to WHDKIF, and have better antioxidant activity. The invention has important significance for treating hyperuricemia.
PURPOSE: Gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) may be related to surgical technique. The fact that there is a lack of technical standardization may explain large differences in GERD incidence. The aim of this study is to evaluate auto- and hetero-agreement for SG technical key points based on recorded videos.
METHODS: Ten experienced (minimum of 5 years performing bariatric surgery, minimum of 30 SG per year) bariatric surgeons (9 (90%) males) were selected. Participants were invited to send an unedited video with a typical laparoscopic SG (first round of the Delphi process). Videos were cropped into small clips comprising 11 key points of the technique. All anonymized clips (including their own) were returned to all surgeons. Individuals were asked to agree or not with the technique demonstrated (second round). The percentage of agreement was presented to the entire group that was asked for a second vote (third round).
RESULTS: Agreement was poor/fair for all points except hiatal repair that had a very good agreement in the second round. For the third round, there was a slight increase in agreement for distance esophagogastric junction/proximal stapling and gastric mobilization for stapling and a slight decrease in agreement for gastric tube final shape. Only 1 (10%) surgeon recognized that he evaluated his own video. Five (50%) surgeons disagreed with themselves on 1 or more points.
CONCLUSION: SG lacks intrasurgeon and intersurgeon agreement in technical key points that may justify significant differences in GERD incidence after the procedure.
Process comprises reaction of 7-(3,5-dichloro 5-pyridone-1-yl acetamide) cephalosporanic acid with 3-thio-5-methyl 1,3,4-thiadiazo cpd.. To increase performance, the cpds. are suspended via an aq. sodium bicarbonate soln. at pH 5 with stirring under nitrogen for 1-2 hours. - The stirring temp. is 50-100 degrees C, the mixt. is treated with ice water pretreated with aluminium oxide and the ppte., with antimicrobe properties is washed with water and recrystallised.
A method is described for separating, retrieving and concentrating platelets from whole blood relying on aggregation of the platelets followed by filtration. This method eliminates the need of a centrifuge for separating said cells from blood. To obtain cellular concentrates of platelets, blood is mixed with compatible agents that will aggregate cells while retaining contained growth factors. The resulting aggregates can then be separated from blood by filtration. If desired, the filtercaptured aggregates are subject to a brief washing cycle where they are washed clean of residual aggregating agent, plasma, and red cells. Aggregates can then be partly or wholly deaggregated and the cells retrieved. The result is a suspension of cells and small aggregates with therapeutic levels of concentrated blood cells with included growth factors that are available for delivery to a wound site. A device (10, 48) that accomplishes the aforementioned process is also described.
Approximately, 40-50 participants with Parkinson's Disease (H\&Y stage 2 to 3) will be enrolled in this study. Participants who provide informed consent will be randomized 1:1 to either group golf instruction or group Tai Chi classes. Participants will be evaluated before and after the intervention with a battery of cognitive, motor and balance assessments including the UPDRS, the Mini-BESTest of balance, and timed up and go tests. They will participate in classes twice weekly for 10 weeks which will be provided free of charge. At the end of the intervention period they will repeat the assessments. The primary outcomes of the study are feasibility and tolerability. The key secondary objectives are to measure the efficacy of golf instruction on measures of balance, risk of falls.
One embodiment provides a method including transmitting a pick-up request to transport a patient within a healthcare facility. The method includes receiving an acceptance indication for the pick-up request. The method includes generating a patient identification request requesting a scan of an identification tag of an individual. The method includes receiving image data and determining whether the image data includes an image of the identification tag. The method includes verifying an identity of the individual. The method includes receiving at least one environment attribute from an environment of the patient. The method includes transmitting a notification indicating successful completion. Other aspects are described and claimed.
Larotrectinib is an inhibitor of the tropomyosin receptor kinases (TRK), TRKA, TRKB, and TRKC. In a broad panel of purified enzyme assays, larotrectinib inhibited TRKA, TRKB, and TRKC with IC50 values between 5-11 nM. One other kinase TNK2 was inhibited at approximately 100-fold higher concentration. TRKA, B, and C are encoded by the genes NTRK1, NTRK2, and NTRK3. Chromosomal rearrangements involving in-frame fusions of these genes with various partners can result in constitutively-activated chimeric TRK fusion proteins that can act as an oncogenic driver, promoting cell proliferation and survival in tumor cell lines.

In in vitro and in vivo tumor models, larotrectinib demonstrated anti-tumor activity in cells with constitutive activation of TRK proteins resulting from gene fusions, deletion of a protein regulatory domain, or in cells with TRK protein overexpression. Larotrectinib had minimal activity in cell lines with point mutations in the TRKA kinase domain, including the clinically identified acquired resistance mutation, G595R. Point mutations in the TRKC kinase domain with clinically identified acquired resistance to larotrectinib include G623R, G696A, and F617L.
Meal patterns will mimic a standard American diet (50% carbohydrate, 15% protein, 35% fat), providing an isonitrogenous 0.8 g/kg/d protein, and meeting individual estimated daily energy requirements. We have chosen 0.8 g/kg/d as it is the recommend dietary allowance for protein in the US. This arm's protein source will be from plant-based protein (ie impossible burger, black bean burger, soy, etc).
The Claimed Invention is the topical-to-skin use of generic estradiol, estriol, conjugated estrogens, or any other synthetic estrogen within a non-absorbable generic vehicle of cream, lotion, ointment, shampoo, hair tonic, and wound-healing powder, having no absorbents or deconstructors in their formulas. This invention causes skin basal cells to produce increased quantities of collagen and to retain skin-water resulting in increased skin-thickness. This increased thickness results in improved resilience, resistance to injury, trauma and infection. The target of this invention is the skin and skin only. Specifically, there is no intended absorption of hormone into the circulation to result in side effects or risk. Any possible unintended and minimal quantity of hormone absorbed would be metabolized normally by the liver and excreted in the urine without risk or awareness to the user. Improving skin health and healing existing injuries/disease can save individuals from mid 30's and older, and society in general millions of dollars annually in skin-related health care costs.
Patients receive temozolomide PO daily and radiation therapy over 5 days a week (weekdays only) for 6 weeks. Beginning 28 days after the last dose of radiation therapy, patients receive temozolomide PO for 12 months in the absence of disease progression or unacceptable toxicity.
OBJECTIVE: The ultrasonographic characteristics of lymph node metastasis in breast cancer patients were retrospectively analyzed, and a predictive nomogram model was constructed to provide an imaging basis for better clinical evaluation.
METHODS: B-mode ultrasound was used to retrospectively analyze the imaging characteristics of regional lymph nodes and tumors. Pathological examination confirmed the presence of lymph node metastasis in breast cancer patients. Univariable and multivariable logistic regression analyses were performed to analyze the risk factors for lymph node metastasis. LASSO regression analysis was performed to screen noninvasive indicators, and a nomogram prediction model was constructed for breast cancer patients with lymph node metastasis.
RESULTS: A total of 187 breast cancer patients were enrolled, including 74 patients with lymph node metastasis in the positive group and 113 patients without lymph node metastasis in the negative group. Multivariate analysis revealed that pathological type (OR = 4.58, 95% CI: 1.44-14.6, p = 0.01), tumor diameter (OR = 1.37, 95% CI: 1.07-1.74, p = 0.012), spiculated margins (OR = 7.92, 95% CI: 3.03-20.67, p < 0.001), mixed echo of the breast tumor (OR = 37.09, 95% CI: 3.49-394.1, p = 0.003), and unclear lymphatic hilum structure (OR = 16.07, 95% CI: 2.41-107.02, p = 0.004) were independent risk factors for lymph node metastasis. A nomogram model was constructed for predicting breast cancer with lymph node metastasis, incorporating three significantly correlated indicators identified through LASSO regression analysis, namely, tumor spiculated margins, cortical thickness of lymph nodes, and unclear lymphatic hilum structure. The receiver operating characteristic (ROC) curve revealed that the area under the curve (AUC) was 0.717 (95% CI, 0.614-0.820) for the training set and 0.817 (95% CI, 0.738-0.890) for the validation set. The Hosmer-Lemeshow test results for the training set and the validation set were p = 0.9148 and p = 0.1648, respectively. The prediction nomogram has good diagnostic performance.
CONCLUSIONS: B-mode ultrasound is helpful in the preoperative assessment of breast cancer patients with lymph node metastasis. The predictive nomogram model, which is based on logistic regression and LASSO regression analysis, is clinically safe, reliable, and highly practical.
Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
The present invention relates to a compound microcapsule of fish oil without fishy smell and a preparation method thereof. The product of the present invention does not have fishy smell. The protective action of a wall material on DHA and EPA in fish oil is enhanced through improving the preparation process. The product of the present invention adopts natural colloid, carbohydrate and protein as the wall materials for microencapsulation and fish oil without fishy smell in which V(E) is added as a core material, the prescription of raw materials is improved, and a multilayer compound wall film is formed by adopting a multiple embedding technique. Thus, the oxidization of DHA and EPA caused by external factors can be reduced effectively, and the product can be preserved and used for a long time. The product of the present invention can be used in the technical fields of medicines, foods, drinks, etc.
BACKGROUND: The COVID-19 disease has a negative impact on the psychophysiological health of populations worldwide, including a decrease in overall physical performance and an increase in fatigue. Fatigue was one of the main symptoms reported by patients and persisted for several weeks after infection with COVID-19. Although the phenomenon of fatigue is still poorly understood, physical activity can be a supportive factor in combating feelings of fatigue and lack of energy. The purpose of this research was to assess the physical activity (PA) and fatigue levels of teachers in Poland and the United Kingdom in the first year after the COVID-19 pandemic.
MATERIAL AND METHODS: The online research was carried out among 410 teachers from Poland and the United Kingdom. The PA level was assessed using the International Physical Activity Questionnaire (IPAQ). The level of fatigue was measured using the Modified Fatigue Impact Scale (MFIS).
RESULTS: Polish teachers, regardless of sex, are more physically active (the differences relate mainly to walking and moderate activity). When assessing the level of fatigue, there is a significant difference between men and women - the former indicate a higher degree of fatigue, with the difference between the sexes being particularly large in the Polish community. Quite clearly, there is an association between less activity (except walking) and more fatigue. All models show a statistically significant effect of total fatigue on total effort. Physical activity is not very strongly correlated with age but the level of fatigue increases with age.
CONCLUSIONS: The problem of teacher fatigue is unfortunately widespread. They should be encouraged to engage in as much PA as possible during the day. When planning and targeting fatigue reduction campaigns, PA should be encouraged and variables such as age, sex should be taken into account. Med Pr Work Health Saf. 2024;75(2):103-112.
<P>PROBLEM TO BE SOLVED: To provide a formulation for the treatment of asthma having desirable solubility, stability, low toxicity, accurate dosage, correct particle size and/or compatibility with a usual valve assembly of a dosage-metering inhaler and not containing CFC (chlorofluorocarbon), and a method for producing the same.  <P>SOLUTION: An aerosolized formulation for the treatment of asthma (which contains mometasone furoate and formoterol fumarate) and the method for preparing the same are disclosed. The invention relates to a process for producing the nontoxic formulation that does not substantially contain CFC and possesses improved stability and compatibility with medicines and is relatively easily produced. The formulation is produced according to an ordinary procedure in the art for other aerosol compositions. Typically, all components other than this atomizing agent are mixed and introduced in an aerosol can.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Colorectal cancer (CRC) screening saves lives, but screening rates are low among underserved populations, particularly Latinos. The screening rate in the predominantly Latino population served by San Ysidro Health Center (SYHC, a Federally Qualified Health Center (FQHC)), is just 31%, similar to that reported for Latinos nationally, but lower than the overall national average of 65%. Previous research has demonstrated that inreach interventions at point of medical care such as patient navigation after screening referral, and outreach outside of usual medical care (such as with mailed invitations) can increase screening rates among underserved populations. However, since these have undergone limited evaluation among low income predominantly Spanish-speaking Latinos, it is unclear which approach is best, and whether implementing both approaches would be synergistic for optimizing screening rates. We hypothesize that two culturally and linguistically tailored interventions: a) an inreach strategy (IR, consisting of community health worker-delivered in clinic education regarding CRC screening and other components), and b) an outreach strategy (OS, consisting of mailed invitations to complete screening with an enclosed fecal immunochemical test (FIT) and telephone reminders) can substantially increase screening, and further, that the two interventions together will be substantially better than either alone. To test these hypotheses, we propose a randomized trial comparing usual care, IR, OS, and IR+OS for CRC screening.