anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The proposed work will improve our understanding of historical, fallout-related radiation doses received by residents of villages in Kazakhstan immediately downwind from the Semipalatinsk Nuclear Test Site (SNTS), where multiple nuclear test explosions were carried out between 1949 and 1962. In collaboration with scientists at the Institute for Biophysics in Moscow, NCI has developed a combined bi-national dose reconstruction methodology based on lessons learned from studying radioactive fallout from tests at the SNTS in Kazakhstan, the Nevada Test Site in the United States, and other test sites. Gamma rays from radionuclides such as cesium 137 in fallout are highly penetrating and can affect all organs even when the radioactive source is outside the body, whereas less-penetrating beta particles from iodine 131, also plentiful in fallout, mainly affect the thyroid gland when ingested in milk from dairy animals grazing on contaminated pasture. We are particularly interested in both kinds of radiation doses to children, because their thyroid glands are small and very active, tend to concentrate ingested iodine, and are highly sensitive to radiation carcinogenesis. The conditions of fallout exposure in Kazakhstan are directly relevant to those following a hypothetical nuclear accident or radiation terrorism incident involving high levels of local fallout.

We propose a field study in Kazakhstan to investigate aspects of typical daily village life in areas affected by fallout that might influence individual radiation doses to the thyroid gland. Using focus group interviews, we will collect retrospective information about factors influencing radiation dose to the thyroid gland in children of two distinct ethnic groups (Kazakh and European). These factors include milk and milk product consumption, dependence on different species of dairy animals known to differ with respect to concentration of iodine in milk, seasonal practices of pasturing and supplemental feeding of dairy animals at the time of the nuclear tests, time children typically spent outdoors, and radiation shielding provided by dwellings and other buildings. We will also ask about protective measures taken at the time, such as details of temporary evacuations of villages predicted to be in the fallout paths from particular tests. These data will fill key gaps in the current dose-reconstruction methodology and should result in improved dose estimates, as well as a basis for evaluating and quantifying dosimetric uncertainty and related biases in risk estimates.
High-fat diets contribute to various metabolic disorders. Inulin supplementation has been shown to reduce appetite, lower food intake, and promote weight loss. Although there is evidence that the endocannabinoid system has metabolic effects in the prefrontal cortex, studies investigating the effects of inulin on the endocannabinoid system are limited. This study investigated the impact of inulin on obesity through the endocannabinoid system in the prefrontal cortex. Twenty-four male Wistar rats were fed one of four diets over 12 weeks. Findings indicated that a high-fat diet led to obesity, whereas inulin reduced food intake and supported weight loss. Consequently, inulin supplementation both prevented obesity and significantly decreased the expressions of Adrb3 and Adcy1, and anandamide and 2-arachidonylglycerol levels in the prefrontal cortex. Additionally, inulin lowered leptin in circulation and stimulated Trpv1. Thus, inulin may mitigate obesity development, possibly by modulating gene expressions linked to obesity in the prefrontal cortex via endocannabinoids.
The invention relates to a pharmaceutical composition sustained-release implant containing caspofungin acetate and a preparation method thereof. The pharmaceutical composition sustained-release implant is characterized in that the active ingredient of the medicine is echinocandins antifungal drug caspofungin acetate. In addition, the sustained-release implant also comprises polyene and triazole antifungal drugs with a synergistic effect with the caspofungin. The active ingredient of the medicine is coated in a high polymer material carrier with biodegradability and biocompatibility according to a certain ratio. The active ingredient is prepared into sustained-release microspheres to be directly pressed into tablets of a certain shape, and the tablets are used for implant, so that a long-acting sustained-release effect is achieved. The sustained-release period of the sustained-release implant lasts for several days or several months, the drug administration frequency is obviously reduced, the bioavailability is improved, the toxic and side effects are reduced, and thus the pharmaceutical composition sustained-release implant containing caspofungin acetate is beneficial for clinical treatment.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, and namely to ophthalmology, and can be used as an anaesthesia care in extended ophthalmic surgeries or in impossible endotracheal narcosis of the patients suffering a severe accompanying pathology. That is ensured by needle stick-in through skin of an upper eyelid in a projection of frontal incisure in a superonasal region. Then the needle is moved further tangentially to the eyeball. An anaesthetic is introduced in subcutaneous fat between optic canal and superior orbital fissure in amount 2-3 ml. ^ EFFECT: method allows fast and long-term anaesthetic effect simultaneously with reduced dosage of the anaesthetic due to its delivery to the basic motor and sensory nerve trunks of the eyeball. ^ 1 ex
BACKGROUND: Best practice guidelines from the ACS recommend that patients with open fractures receive antibiotics within 1-hour of presentation. Checklists are effective mechanisms for improving safety and compliance in surgical settings. The current study investigates implementation of a trauma bay checklist, referred to as MARTY, to improve administration of antibiotics in open extremity fractures at a level I trauma center.
METHODS: Retrospective pre-post design. Population consisted of trauma alerts from January to December 2021 (pre-MARTY) and 2022 (post-MARTY) with open fractures. Outcome measures included antibiotics administered within 1-hour of presentation and in the trauma bay. Bivariate and multivariate analyses were performed to estimate differences in both measures.
RESULTS: Our sample included 339 encounters, 174 pre-MARTY and 165 post-MARTY implementation. In the pre-MARTY period, 57.5% of encounters received antibiotics within 1-hour of presentation with 46.0% occurring in the trauma bay, in comparison to 65.5% and 54.5% in the post-MARTY period. In adjusted models, there were greater odds of antibiotic administration within 1-hour (OR = 1.654, P = .038) and prior to leaving the trauma bay (OR = 1.660, P = .041) than pre-MARTY. Encounters with higher-grade fractures were more likely to receive timely antibiotics (P<=.001).
DISCUSSION: Our study estimates improved compliance of antibiotic administration after implementation of MARTY after adjusting for encounter characteristics. Findings from this study demonstrate improved compliance, but this compliance is often still lacking in those with higher injury severity scores. Findings from this study may be used to inform approaches to further improve trauma care.
Participants received immediate breast reconstruction using a sub-muscular tissue expander (TE) and acellular dermal matrix (ADM) sling placed during the same surgery. This was followed by post-mastectomy radiation therapy (PMRT) no sooner than a minimum of 6 weeks and optimally 6 months, if adjuvant chemotherapy was required. The prescribed chest-wall dose was 50 -50.4 gray (Gy) in 25-28 fractions given once daily over 5-7 weeks with a 0.5-centimeter (cm) bolus to the scar every other day. Permanent reconstruction was performed at least 5 months after completion of PMRT.
Name Oral rehabilitation. Patients receiving dental treatment will be allocated to one of two different treatment groups based on individual treatment need and proven experience. Patients in group 1 will be treated with minimal invasive treatment, with restorative composite fillings. Patients in group 2 will be treated with prosthetic rehabilitation, dental crowns.
Compositions of hydroxyl-terminated dendrimers covalently conjugated to functional nucleic acids (D-FNA) and methods of use thereof have been developed for the prevention, treatment or diagnosis of one or more diseases or disorders in a subject in need thereof. Covalent conjugation of FNA with dendrimers greatly increases serum half-life and bioavailability, protecting the payload from protein adsorption and enzymatic degradation. Preferably, the functional nucleic acid is covalently conjugated to the dendrimer via a functional releasable coupling element for intracellular release of FNA within activated macrophages, including Tumor Associated Microglia (TAM). An exemplary functional releasable coupling element is a glutathione-sensitive coupling element. Exemplary FNAs include antisense RNAs, micrornas, and silencing RNAs. The composition is particularly suitable for treating or ameliorating the symptoms of inflammatory and proliferative diseases. Methods of treating a human subject having or at risk of an inflammatory disease and a proliferative disease are provided.
A composition and method is provided to modify sperm fertility and sex ratio of mammalian offspring. The composition includes an amount of a class of compounds of phenoxazine or phenothiazine, having the structure (see FIG. l) and ionic derivatives thereof, wherein R1 is H, a lower alkyl group or N (R3)2, R2 is N, S, O, and R3 is H or a lower alkyl group. A second component of the composition is an amount of an electron transfer agent capable of oxidizing a reduced cofactor (NADPH or NADH). A third component of the composition is an amount of a hexose sugar and/or the phosphorylated esters of such. When mixed with living sperm prior to or at the time of insemination, the composition results in modified rates of conception and an alteration of birth sex ratio in mammal species.
To assist in the creation of medical certificates by a doctor.SOLUTION: When an insurance claim is issued from an insurance contractor terminal 60 to an insurance company terminal 70 ((1) in FIG. 16), a request for creation of a medical certificate is transmitted from the insurance company terminal 70 to a medical certificate creation system 16 ((2) in FIG. 16). In the medical certificate creation system 16, this request for creation of a medical certificate and patient information that is transmitted together with the request are acquired, and DPC receipt data is acquired from a receipt data storage unit 30 using the acquired patient information, as well as examination file data is acquired from an examination file data storage unit 32 ((3) in FIG. 16). Meanwhile, in the medical certificate creation system 16, data to be written to the medical certificate is extracted from the acquired DPC receipt data and examination file data and then written to the medical certificate ((4) in FIG. 16), with the medical certificate displayed (outputted) to a display unit ((5) in FIG. 16).SELECTED DRAWING: Figure 16
PURPOSE:To obtain the titled cosmetic, by kneading a powdery cosmetic containing a large amount of titanium mica iridescent pigment and a small amount of an oil with an organic solvent, extruding the kneaded mixture in the form of a rod, cutting the rod, filling in a container, compression-molding the rod and removing the organic solvent from the rod to dryness. CONSTITUTION:A powdery cosmetic containing 70-90wt% titanium mica iridescent pigment (an iridescent pigment produced by coating the surface of mica with titanium oxide) and 4-8wt% oil (e.g. squalane, liquid paraffin, etc.) is kneaded with an organic solvent (e.g. methanol, acetone, etc.). The obtained pasty mixture is kneaded in the form of a rod, cut in a proper length, filled in a container such as an inner dish, compression-molded and dried by removing the organic solvent from the product to obtain the titled cosmetic. The compression molding can be carried out even under low pressure of e.g. about 5-10kg/cm<2>. The cosmetic produced by the above process has high covering property and excellent adhesivity to the skin and gives durable makeup.
There is provided a method of treating a chronic inflammatory condition of the lower urinary tract, the method comprising administering to a patient in need thereof an effective amount of a formulation selected from an IL-1 β inhibitor and an MMP inhibitor, or a protein selected from ASC or NLRP-3. Diagnostic methods are also described and claimed. The invention also relates to an IL-1 inhibitor for use in a method of treating, alleviating or reducing pain and pain-related symptoms of chronic pelvic pain syndrome. The IL-1 inhibitor may be an IL-1 receptor antagonist. The IL-1 inhibitor may be anakinra. The chronic pelvic pain syndrome can be a urinary system pain syndrome, an external genitalia gynecological pain syndrome, an internal pelvic pain syndrome, and a gastrointestinal pelvic pain syndrome.
OBJECTIVE: The objective of this study was to assess the relationship of arteriovenous malformation (AVM) blood flow measured by quantitative MR angiography (QMRA) in nonruptured AVMs with MR-detected microhemorrhage.
METHODS: All patients with unruptured AVMs who received baseline QMRA and gradient echo or susceptibility-weighted MRI were retrospectively reviewed (2004-2022). Imaging data, clinical history, and AVM angioarchitectural and flow features were collected and assessed. AVM flow was calculated from the difference of flow within primary arterial feeders from their contralateral counterparts. A review of the MR images determined the presence of microhemorrhages. Analysis of descriptive statistics, chi-square test, and binomial logistic regression were performed.
RESULTS: Of 634 patients with cerebral AVMs at a single center, 89 patients met the inclusion criteria (54 with microhemorrhage and 35 without microhemorrhage). The calculated AVM flow was significantly higher in the group with a microhemorrhage (447.9 ± 193.1 ml/min vs 287.6 ± 235.7 ml/min, p = 0.009). In addition, the presence of venous anomaly, arterial ectasia, and diffuse nidus was significantly associated with microhemorrhage (p = 0.017, p = 0.041, and p = 0.041, respectively). Binary logistic regression found that higher flow predicted the presence of microhemorrhage (OR 1.002, 95% CI 1.000-1.004; p = 0.031). The highest AVM flow quartile significantly predicted the presence of venous anomaly (OR 3.840, 95% CI 1.037-14.213; p = 0.044), diffuse nidus (OR 6.800, 95% CI 1.766-25.181; p = 0.005), and arterial ectasia (OR 13.846, 95% CI 1.905-122.584; p = 0.018).
CONCLUSIONS: This study represents the first to examine the association between flow measurements on QMRA with microhemorrhage in unruptured AVMs. Higher AVM flow, venous anomaly, arterial ectasia, and diffuse AVM nidus were related to a higher likelihood of AVM microhemorrhage. Higher AVM flow was present in AVMs with venous anomalies, a diffuse nidus, and arterial ectasia, indicating a possible interaction between these angioarchitectural findings, AVM flow, and microhemorrhage. These findings suggest a relationship between higher AVM flow and the risk of microhemorrhage.
Objective To observe the expression of anti-β2 glycoprotein I (β2GPI) autoantibody in connective tissue diseases and its relationship with the degree of inflammation and immune function. Methods Patients with broad connective tissue diseases including connective tissue disease (CTD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), and systemic lupus erythematosus (SLE) were observed. β2GPI was quantified by chemiluminescence, ESR was measured by Weil's method, and C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated polypeptide (CCP) antibody were measured by automatic biochemical analyzer. Results β2GPI and their subtypes were significantly higher in RA patients compared with CTD, SS, and SLE patients. CRP was positively associated with anti-β2GPI antibody and anti-β2GPI antibody IgM in patients with connective tissue disease. ESR was positively associated with anti-β2GPI antibody. Anti-β2GPI antibody and anti-β2GPI antibody IgM were elevated in the abnormal CRP group compared with the normal CRP group. Compared with the ESR normal group, anti-β2GPI antibody and anti-β2GPI antibody IgG were elevated in the ESR abnormal group. Anti-β2GPI antibody was positively correlated with ESR and anti-CCP antibody in RA patients. Anti-β2GPI antibody IgG was positively correlated with RF. Conclusion β2GPI can be used as a predictor of the degree of inflammation and assessment of immune disorders in CTD.
Patients randomised to the control group will receive a prescription for a matching placebo. The starting dose will be the same as in the experimental group (100 mg three times a day per orally), additional to the analgesics according to standard local practices. Placebo can optionally follow the same dose scheme as described in the experimental arm.
Objective: To explore the feasibility of endoscopic lymph node dissection(LND) with programmed breast approach for the treatment of papillary thyroid cancer. Methods: A case series study. The clinical data of 39 patients with papillary thyroid cancer who underwent endoscopic LND treatment with programmed breast approach in Shenzhen People's Hospital from January to November 2022 were retrospectively analyzed. There were 10 males and 29 females, aged (35.95±10.17) years. LND time, total surgical time, intraoperative bleeding volume, postoperative drainage volume, postoperative hospital stay and postoperative complications were analyzed. Results: Among 39 patients, there were 18 cases of unilateral thyroid cancer, 21 cases of bilateral thyroid cancer, 35 cases of unilateral LND, and 4 cases of bilateral LND. The maximum diameter of thyroid cancer lesions was (1.48±0.69) cm, and the maximum diameter of lymph node metastases was (1.63±0.58)cm. The operative time of unilateral neck dissection was (124.11±19.92) min (102-170 min), and the total operative time was (226.42±55.68) min (110-390 min). The number of lymph nodes cleaned was (32.40±10.44)(12-54), the number of metastasis and detection was 207/1 393. The postoperative drainage volume was (174.64±82.33) ml(41-350 ml). There were no neck hematomas, no skin burns or no shrugging disorders in the postoperative period. There were 7 cases of numbness and discomfort in neck skin sensation, which gradually relieved after half a year. Postoperative discharge time (4.77±1.94) d(3-15 d). Conclusion: It is safe and feasible to treat papillary thyroid cancer with endoscopic LND with programmed breast approach, which can improve surgical efficiency and clinical application value.
Arrhythmia is a life-threatening cardiac condition characterized by irregular heart rhythm. Early and accurate detection is crucial for effective treatment. However, single-lead electrocardiogram (ECG) methods have limited sensitivity and specificity. This study propose an improved ensemble learning approach for arrhythmia detection using multi-lead ECG data. Proposed method, based on a boosting algorithm, namely Fine Tuned Boosting (FTBO) model detects multiple arrhythmia classes. For the feature extraction, introduce a new technique that utilizes a sliding window with a window size of 5 R-peaks. This study compared it with other models, including bagging and stacking, and assessed the impact of parameter tuning. Rigorous experiments on the MIT-BIH arrhythmia database focused on Premature Ventricular Contraction (PVC), Atrial Premature Contraction (PAC), and Atrial Fibrillation (AF) have been performed. The results showed that the proposed method achieved high sensitivity, specificity, and accuracy for all three classes of arrhythmia. It accurately detected Atrial Fibrillation (AF) with 100% sensitivity and specificity. For Premature Ventricular Contraction (PVC) detection, it achieved 99% sensitivity and specificity in both leads. Similarly, for Atrial Premature Contraction (PAC) detection, proposed method achieved almost 96% sensitivity and specificity in both leads. The proposed method shows great potential for early arrhythmia detection using multi-lead ECG data.
TLC will start in the late first trimester or early second trimester and run for \~6-10 sessions. Groups of 2-10 consented women, with two or more GDM risk factors, will meet under the supervision of an obstetric provider (nurse practitioner or MD) and co-facilitator (health educator, nutritionist, or nurse) for two-hour sessions. A major focus of TLC will be education, and much of each visit will be spent on pregnancy, exercise/nutrition education, and behavioral health.
Acute Kidney Injury (AKI) is frequently observed in hospitalized patients in intensive care units, often caused by renal ischemia-reperfusion injury (IRI). IRI disrupts the function of various 'remote organs' such as the lungs, pancreas, intestine, liver, heart, and brain through inflammation, oxidative stress, apoptosis, leukocyte infiltration, and increased urea and creatinine levels. Gender differences in renal IRI-induced injury are noted. H2S, an endogenous gaseous modulator, shows potential in vasodilation, bronchodilation, and hypotension and can regulate apoptosis, inflammation, angiogenesis, metabolism, and oxidative stress. This study aims to investigate the protective effects of NaHS on brain, heart, and lung injuries following renal IR and to assess the oxidative system status as a potential mechanism in male and female rats.Forty-eight Wistar rats were randomly divided into eight groups (n = 6): Control/Saline, Sham/Saline, IR/Saline, and IR/NaHS in both sexes. Forty-five minutes of bilateral renal ischemia followed by 24-hour reperfusion was induced in the IR groups. NaHS (100µM/Kg, IP) was administered 10 min before clamp release in treated groups. BUN, SCr, BUN/SCr, albuminuria, histopathology, and oxidative stress biomarkers of the brain, heart, and lung were assessed as remote organs. IR increased serum markers of renal function, albuminuria, malondialdehyde levels, and tissue injury scores while reducing nitrite levels and superoxide dismutase and glutathione peroxidase activities. NaHS treatment reversed the adverse effects of IR in remote organs in both sexes, although it showed limited improvement in renal function. Our findings demonstrate that NaHS has a beneficial effect on remote organ injury following renal IR by mitigating oxidative stress, with noted tissue-specific and gender-specific differences in response. These findings suggest NaHS as a potential therapeutic agent for mitigating multi-organ injury after renal IR, with effects varying by tissue and gender.