anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To investigate the diagnosis and treatment of intraosseous ganglion cyst in the ankle region.
METHODS: A retrospective analysis was performed on the diagnosis and treatment of 18 patients with intraosseous ganglion in the ankle region from January 2005 to March 2016. There were 11 males and 7 females, with an average age of 40.4 years (22-74 years). Thirteen of these had mild intermittent localized pain in the ankle and five were asymptomatic and fortuitously found on images. According to the location of the intraosseous ganglion cyst, nine were located in the distal end of tibia, seven were in the distal end of the fibula, and two were in the talus. After curettage of intraosseous ganglion, 15 cases were filled with autogenous iliac bone and 3 cases with artificial bone.
RESULTS: Fifteen cases were diagnosed with radiographs and CT scans, two cases with MR images, and one case was confirmed by postoperative pathology. The cyst contents were jelly-like material with sclerotic bone margins. The mean size of the intraosseous ganglion cyst was 1.5 cm × 1.5 cm × 1 cm. Hematoxylin and eosin (H&E) staining of the tissue showed fibrous tissue, collagenous fiber, mucoid, and a few fibroblasts. Eighteen cases were followed up for 11 months to 10 years, with an average of 5.4 years. No recurrence was found. Sixteen patients were asymptomatic after surgery. Two cases of ankle pain occurred at 1 year and 6 months postoperatively, respectively. According to the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale, the mean AOFAS ankle-hindfoot score improved from 78.2 ± 13.7 points preoperatively to 97.3 ± 4.5 points at the final follow-up.
CONCLUSION: For the intraosseous ganglion cyst in the ankle region, whether there are clinical symptoms or not, the cyst should be curettaged and the cavity should be filled with bone graft. The operation result is satisfactory.
INTRODUCTION: Frailty has a significant impact on the overall quality of life of older cancer survivors, but the relationships among frailty symptoms are not well understood. This study aims to explore the specific associations among multidimensional symptoms of frailty among older cancer survivors by employing network analysis to provide supportive evidence for targeted interventions in the future.
MATERIALS AND METHODS: Data were obtained by cluster sampling from three large Grade-A tertiary hospitals in Shandong Province, China, and collected through face-to-face interviews by trained investigators. We included patients who were diagnosed with a solid malignant tumor at the age of 60 years or older. Frailty indicators were measured by the Groningen Frailty Indicator (GFI) and analyzed primarily through network analysis, including network estimation, centrality, and stability analysis. The relative importance of a node in a network was tested by centrality analyses, and Spearman correlations were applied to estimate the relationships between symptom pairs (symptom score) and symptom clusters (standardized symptom score) in the symptom network. In terms of centrality, the indexes of strength, closeness, and betweenness were adopted to measure the importance of nodes.
RESULTS: Five hundred and eight older cancer survivors were included, with an average age of 68.4 years (standard deviation [SD] = 5.4), and a higher proportion were male (n = 307[60.4%]). The prevalence of frailty among older cancer survivors was 58.9% (n = 299), with a mean GFI score of 4.46 (SD = 2.87). The strongest edge was between "dressing and undressing" and "going to the toilet" (r = 0.58). The nodes with the higher strength centrality were "going to the toilet" (rS=1.09), "walking around outside" (rS=0.97), and "part of social network" (rS=0.96); and the nodes with the higher closeness centrality were "mark physical fitness" (rC=0.005), "calm and relaxed" (rC=0.005), and "nervous or downhearted" (rC=0.005).
DISCUSSION: This study demonstrated that older cancer survivors in China have a high prevalence of frailty, with self-care and social participation-related symptoms playing a key role in the multidimensional network of frailty symptoms. Psychological symptoms can rapidly influence other symptoms within this network. Therefore, prioritizing psychological symptoms in the assessment of older adults with cancer is essential for effective frailty management.
Conductive hearing loss with a normal tympanic membrane is a common reason for otolaryngology consultation, with otospongiosis being the most frequent cause and House syndrome being extremely rare, requiring systematic investigation. We report the case of a 31-year-old woman who presented with conductive hearing loss with a normal tympanic membrane. A temporal bone computed tomography (CT) scan confirmed a House-Goodhill syndrome due to fixation of the malleus head. Surgical intervention was considered to remove the attic bone synostosis with the malleus head, resulting in a significant clinical improvement. The Goodhill syndrome is a rare condition that causes hearing loss with a normal eardrum. The surgery can highly improve the hearing function.
<P>PROBLEM TO BE SOLVED: To provide a method and a composition for enhancing an immune response.  <P>SOLUTION: The method and composition for enhancing an immune response in a subject comprises administering an inhibitor of IL-13 or an inhibitor of an NK-T cell to the subject. This method can be used to prevent growth of a tumor in the subject (e.g., to inhibit tumor recurrence or metastasis). The method can also be used to enhance a response to a vaccine in a subject. The method is based in part on the discovery that administration of an inhibitor of IL-13 to a subject or disrupting NK-T cell function in a subject inhibits recurrence of the tumor.  <P>COPYRIGHT: (C)2009,JPO&INPIT
A document access and retrieval system for use in a hospital laboratory environment. The system permits users of a main application to obtain customized, user-specific access to various documents, internet addresses and other external links based on the application subparts or objects to which the user has authorized access. The access links appear as submenu items appearing under the Help menu associated with a selected application object. The system includes a links processor that is interconnected to a links map which correlates various software application objects with the security level of a system user. The system includes a security processor which evaluates user security data and then requests a list of available access link information from the main application. Users cannot access parts of the application to which they do not have specific access. The system enables administrators of model software based applications to add and manage links to external sources based on the user's role in the application and the user's security access.
An agent contg. (A) antiviral substances and/or (B) organic and/or inorganic polymers with inorganic and/or organic anionic gps. (polyanions) in physiologically acceptable carrier particles is new. USE/ADVANTAGE - The agent can be used in the prophylaxis and therapy of viral infections esp. of cells which take up viruses by endocytosis. The agent can be used to inhibit the replication of viruses in these cells. Replication is inhibited by inclusion in lysosomes esp. secondary lysosomes. The agent can be used in the prophylaxis and therapy viral infections of leucocytes, fibroblasts, macrophage, myeloid cells, phagocyting non-myeloid cells and/or Fc receptor-carrying cells
The invention is a method and process of facilitating detection of a nail surface by digitizing devices. The detection method and process is facilitated by applying a coating composition or a stencil to the nail surface. The method and process utilizes a coating composition which is applied to the nail surface. The coating composition is derived from any substance that can be applied to a nail surface, which may include opaque and/or matte type paints or stencils which digitizing devices would be benefited to utilize in distinguishing the nail surface from surrounding tissue. The coating composition may be applied permanently or temporarily. The coating composition may be soluble or non-soluble. The simple application method and process results in a wide scope for application as, for example, to a fingernail or toenail.
The invention provides a medical hydrogel for treating gynecological diseases or skin diseases and an application of the medical hydrogel. The medical hydrogel comprises a main drug and an auxiliary material, wherein the main drug comprises echinacea hormone and chitosan. According to the medical hydrogel, echinacea hormone is applied to drugs for external use for the first time. Compared with internal drugs, echinacea hormone can directly reach the diseased region with less dosage, so that a better curative effect is realized. By means of good biocompatibility of chitosan, effective delivery concentration to echinacea hormone is maintained, so that the synergistic effect such as the medicine effect time is prolonged. Even if echinacea hormone is mutually fused with chitosan and echinacea hormone and chitosan are attached to the affected skin or the surface of mucosa, a protective layer is formed. In addition, echinacea hormone attached to the affected skin or the surface of mucosa further can effectively stimulate growth of glucosamine and fibroblast so as to promote the defense capability of skin or mucosa. Echinacea hormone can stimulate the immune system to increase the quantity and activity of leukocytes and the phagocytic ability of macrophage, so that the curative effect of single medication is enhanced.
All patients who are enrolled in study with at least one Fried criteria will have a Dual-energy X-ray absorptiometry (DXA) to measure lean muscle mass adjusted for body mass index. As part of the usual care in the Frailty Clinic patients will also have a clinical examination, a standard biological sample (requiring 15 ml of blood); an evaluation of the cognitive and functional performances, of their medico-economic situation and lifestyle.
Participants (18-35y) will receive a constant dose of fish oil supplementation throughout the intervention period of the study. Total amount of EPA/DHA received throughout the 12 weeks supplementation period will be the same as the loading groups.
40 subjects will be enrolled and randomized to participate in this study. A 60 minute TES stimulation sequence consisting of a SO frequency stimulation (TES SO) using the NeuroConn DC Stimulator PLUS or a sham stimulation will be administered during the second hour of a two hour nocturnal sleep period. During wake period subjects will be tested using various cognitive, subjective and objective sleepiness and mood measures. Vital signs measurements will be taken to monitor general health issues. Up to 4 subjects will be enrolled per study session. Due to logistical reasons, no more then 2 subjects per session can be assigned to the TES SO group.

Screening visit = approx. 2 hours At-home component = 7 days In-laboratory study period = 138 hours Total in-laboratory period = approx. 138 hours per subject Total participation time (at home + in-laboratory components) = 15 days
The control group did not receive any intervention beyond participating in data collection. Patients in this group underwent assessments with the "MoCA" and "SS-QOL" before the study (pre-test/0th week), at the 6th week of the study (interim measurement), and after the completion of the 12-week study (post-test/12th week).
NEW MATERIAL:Antibiotic PA-41746-A2 and its salt. USE:Having antibacterial effect on Gram-positive and Gram-negative bacteria, improved beta-lactamase inhibitory action, useful as a drug as an antibacterial agent, an animal drug, or a disinfectant. Being administred to mem and animals orally or parenterally. Usable as a tablet, capsule, or powder as oral administration, and injection, paint, suppository, etc. as parenteral administration. A dose is generally about 1/10 - about several times that of cephalothin. Also usable as a raw material for pluracidomycin A. PREPARATION:A bacterium belonging to the genus Streptomyces, capable of producing PA-41746-A2, is cultivated in a medium, and the titled compound is obtained from the prepared culture. The medium contains a carbon source, nitrogen source, inorganic salt, etc. as a rule, and the cultivation is carried out by a process commonly used in preparation of antibiotic. Preferably the pH of the medium is 5.5-8.5 and the culture temperature is about 20-40 deg.C.
Group B participants will be exercised for 25 minutes under normal-load walking conditions three times a week for 8 consecutive weeks on the AGT treadmill at a set speed of 3.1 mph at a 0-degree incline. Participants will be blinded to the study groups.
Nanodiamonds can be included in various compositions to take advantage of the ability of nanodiamond to bond with biological materials and to improve mechanical strength. Nanodiamonds can be dispersed in a biologically acceptable carrier to form various nanodiamond compositions. The presence of nanodiamonds can increase binding with many biological materials, making the compositions of the present invention useful for a large variety of purposes such as cleansing, testing and identification of materials, and treatment of adverse conditions. Specific examples of nanodiamond compositions that can be formulated include deodorants, toothpastes, shampoos, antibiotics, dermal strips, DNA test strips, skin cleansers, and the like. Similarly, nanodiamond particles can be included in a cosmetic nanodiamond composition within a cosmetically acceptable carrier. Cosmetic nanodiamond compositions can include, for example, nail polish, eyeliner, lip gloss, exfoliant, and the like.
Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the EV microRNAome, and their potential contribution to therapeutic mechanisms of action. The evidence that miRNA transfer in MSC-derived EVs has a role in the overall therapeutic effects is compelling. However, several questions remain regarding how to reconcile the stochiometric issue of the low copy numbers of the miRNAs present in the EV particles, how different miRNAs delivered simultaneously interact with their targets within recipient cells, and the best miRNA or combination of miRNAs to use as therapy, potency markers, and biomarkers of efficacy in the clinic. Here, we offer a molecular genetics and systems biology perspective on the function of EV microRNAs, their contribution to mechanisms of action, and their therapeutic potential.
Participants in the intervention arm will receive 5 one-on-one sessions over 6 months with a CHW, as well as a manual and written materials on child development. At baseline and exit, all participants will be assessed using instruments to measure demographics and self-perceived barriers.
The invention provides mannanase, the amino acid sequence of which comprises SEQ ID NO.1. The most suitable pH of the mannase is 6.0, and the mannase has higher enzyme activity at pH 3.5-7.0; the pH stability is good; has good protease resistance. The characteristic of high thermal stability can be applied to industrial production requiring high-temperature environment. The mannase can be applied to the feed industry to reduce or eliminate the anti-nutritional effect caused by the increase of viscosity. In addition, it can be used as clarifying agent for fruit juice beverage. The method can also be used for breaking bonds between hemicellulose and lignin by synergistic action with xylanase, so that the use amount of bleaching agent and chlorine is reduced, and the environment is protected, thus showing great potential.
OTR4132 is a new ReGeneraTing Agent (RGTA®) which is a polymer of glucose (α-1,6 bounds, i.e. dextran backbone) engineered to mimic heparan sulphate (HS) in all three mechanical functions (extracellular matrix scaffold element, protector of matrix pro-teins and cellular communication peptides storage sites) but differ from HS by their resistance to glycanases. OTR4132 allows a restoration of the matrix architecture which secondarily facilitates cell survival and recovery at the site of injury.
Fractional laser ablation is a technique developed in dermatology to induce remodeling of skin scars by creating a dense pattern of microinjuries. Despite remarkable clinical results, this technique has yet to be tested for scars in other tissues. As a first step toward determining the suitability of this technique, we aimed to (1) characterize the response to microinjuries in the healthy and cirrhotic liver, and (2) determine the underlying cause for any differences in response. Healthy and cirrhotic rats were treated with a fractional laser then euthanized from 0 h up to 14 days after treatment. Differential expression was assessed using RNAseq with a difference-in-differences model. Spatial maps of tissue oxygenation were acquired with hyperspectral imaging and disruptions in blood supply were assessed with tomato lectin perfusion. Healthy rats showed little damage beyond the initial microinjury and healed completely by 7 days without scarring. In cirrhotic rats, hepatocytes surrounding microinjury sites died 4-6 h after ablation, resulting in enlarged and heterogeneous zones of cell death. Hepatocytes near blood vessels were spared, particularly near the highly vascularized septa. Gene sets related to ischemia and angiogenesis were enriched at 4 h. Laser-treated regions had reduced oxygen saturation and broadly disrupted perfusion of nodule microvasculature, which matched the zones of cell death. Our results demonstrate that the cirrhotic liver has an exacerbated response to microinjuries and increased susceptibility to ischemia from microvascular damage, likely related to the vascular derangements that occur during cirrhosis development. Modifications to the fractional laser tool, such as using a femtosecond laser or reducing the spot size, may be able to prevent large disruptions of perfusion and enable further development of a laser-induced microinjury treatment for cirrhosis.
Sustained delivery formulations comprising a water-insoluble complex of a peptide and a carrier macromolecule are disclosed. The formulations of the invention allow for loading of high concentrations of peptide in a small volume and for delivery of a pharmaceutically active peptide for prolonged periods, e.g., one month, after administration of the complex. The complexes of the invention can be milled or crushed to a fine powder. In powdered form, the complexes form stable aqueous suspensions and dispersions, suitable for injection. In a preferred embodiment, the peptide of the complex is an LHRH analogue, preferably an LHRH antagonist, and the carrier macromolecule is an anionic polymer, preferably carboxymethylcellulose. Methods of making the complexes of the invention, and methods of using LHRH-analogue-containing complexes to treat conditions treatable with an LHRH analogue, are also disclosed.
INTRODUCTION: Tumor-associated macrophages, a major component of the tumor microenvironment, undergo polarization into M2 macrophages (M2), and thereby exert an immunosuppressive effect to induce cancer metastasis. This study strives to uncover a molecular mechanism underlying this event in hepatocellular carcinoma (HCC).
METHODS: Proteasome subunit alpha 5 (PSMA5) expression in liver hepatocellular carcinoma (LIHC) tissues and its association with LIHC patients were predicted using StarBase. PSMA5 level in human HCC cells was manipulated via transfection. Exosomes were isolated from HCC cells, and internalized into macrophages which were cocultured with HCC cells. Exosome internalization was observed after fluorescence labeling. HCC cell migration and invasion were evaluated by wound healing and Transwell assays. Xenograft assay was performed to investigate the role of PSMA5 in in vitro tumorigenesis. M2 polarization was assessed by enzyme-linked immunosorbent assay, quantitative reverse transcription polymerase chain reaction, and immunohistochemistry. PSMA5 expression in exosomes and Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) activation in macrophages and tumors were detected by Western blot analysis.
RESULTS: High PSMA5 expression was observed in LIHC tissues and associated with compromised survival of LIHC patients. PSMA5 knockdown inhibited HCC cell migration and invasion. PSMA5 knockdown in HCC cells downregulated PSMA5 level in exosomes from these HCC cells. HCC cell-isolated exosomes were successfully internalized into macrophages, and facilitated M2 polarization and JAK2/STAT3 pathway activation. HCC cell-secreted exosomal PSMA5 knockdown inhibited the exosome-induced effect on macrophages, and attenuated the promotion induced by exosome-treated macrophages on HCC cell migration/invasion and tumorigenesis along with in vivo M2 polarization and JAK2/STAT3 pathway activation.
CONCLUSION: HCC cell-secreted exosomal PSMA5 knockdown hinders M2 polarization to suppress cancer progression by restraining JAK2/STAT3 signaling.
Aspects herein relate to systems and methods for delivery of biologic agents to the central nervous system. In various embodiments, a method of administering a therapeutic agent to the central nervous system (CNS) is included. The method can include injecting a therapeutic agent into a first cerebrospinal fluid (CSF) region of the subject. The method can further include establishing fluid communication between a fluid reservoir and a second cerebrospinal fluid (CSF) region of a subject, the fluid having a hydraulic pressure at or above an intracranial pressure. The method can further include infusing a hyperosmotic fluid systemically. Other embodiments, including kits and systems are also included herein.