anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject composition that can provide a photo-sensitive element-containing adhesive sheet which cant be applied to the disease site and can effectively treat and prevent the acne by admixing the photo-sensitive element to an adhesive composition. SOLUTION: The objective composition is obtained by admixing (A) a photo- sensitive element, preferably the photo-sensitive element No. 201 to (B) an adhesive composition can be applied to human skin surfaces. The amount of the component B is preferably 0.00001-1 wt.%, more preferably 0.001-0.1 wt.% based on the wholly amount of the composition on the dry basis. The component B is, for example, a mixture of an elastomer as natural rubber, synthetic polyisoprene rubber, styrene-butadiene rubber, styrene-isprene-styrene block copolymer with a tackifier as a terpene resin or polyolefin resin. This composition is preferably used as a photo-sensitive element-containing adhesive sheet by applying this composition to a support sheet.
Nutritional knowledge is among the factors that affect individuals\' eating habits and diet quality. Food consumption is rewarding in itself as it increases energy and eliminates hunger (an unpleasant sensation); however, daily experiences show that people often eat without hunger. Individuals with high body awareness are expected to be aware of the changes occurring in their body and to change these changes. In the project, nutrition knowledge level, reward-related eating behaviour and body awareness will be compared according to gender in healthy young adults, and all these values will be evaluated through scales. The study data will be collected with a single interview by face-to-face interview method. Each participant will be informed about the study and their written and verbal consent will be obtained. The application time of the questionnaires is expected to take approximately 10 minutes for each participant. In case of a difference between genders for the values investigated, it is aimed to develop individuals\' awareness of these situations. In addition, the relationship between these situations will also be evaluated. It is aimed to create awareness for the situations that are found to be related.
The procedure of manufacturing skin care product and beverage product by fermentation of rice bran distillers' grains with hot spring water includes the following steps. Prepare a saccharification mixture: steam a mixture of rice bran and water, and fold in distiller's yeast and diastatic enzyme to obtain the saccharification mixture. Prepare rice bran distillers' grains: saccharify saccharification mixture at temperature in the range of 22 DEG C to 30 DEG C, add bicarbonate hot spring water to the saccharification mixture after the saccharification mixture generating alcohol to obtain a fermentation mixture, and filter the fermentation mixture out of rice bran distillers' grains and rice bran wine. Prepare a first culture fluid: mix rice bran and bicarbonate hot spring water at a weight ratio of 3-10:90-97, and sterilizing it to form a first culture fluid. Prepare first fermentation fluid. And Prepare second fermentation fluid.
Cleviprex was evaluated in an open-label, uncontrolled clinical trial (VELOCITY) in 126 patients with severe hypertension (SBP >180 mmHg or diastolic blood pressure [DBP] >115 mmHg). Cleviprex infusion was initiated at 2 mg/hour and up-titrated every 3 minutes, doubling up to a maximum dose of 32 mg/hour as required to achieve a prespecified target blood pressure range within 30 minutes (primary endpoint). The transition to oral antihypertensive therapy was assessed for up to 6 hours following cessation of Cleviprex infusion.

The blood pressure effect in this study is shown in Figure 5. The average infusion rate was 9.5 mg/hour. The mean duration of Cleviprex exposure was 21 hours.

Figure 5. Mean percent change in SBP (%) during the first 30 minutes of infusion, VELOCITY (severe hypertension)  


Oral antihypertensive therapy was instituted 1 hour prior to the anticipated cessation of Cleviprex infusion. Transition to oral antihypertensive therapy within 6 hours after discontinuing Cleviprex infusion was successful in 91% (115/126) of patients. No patient had IV antihypertensive therapy reinstituted following transition to oral therapy.
1513715 Xylitol-coated confectionery P FERRERO & C SpA 7 March 1977 [5 March 1976] 9587/77 Heading A2B [Also in Division A5] Confectionery dragees are coated with an intimate mixture of 0.5-15, preferably 1-2, wt. parts normally solid fatty substance and 100 wt. parts (as anhydrous) xylitol. The fatty substance may comprise mono-, di- and triglycerides of palmitic, oleic and stearic acid, e.g. cocoa butter. The coating may include an emulsifier and thickener and may be applied as an aqueous solution with the fatty substance in molten state. Anchoring gum layers may be present. Suitable substrates are listed and may include sweeteners.
Red blood cells are destroyed when the shear stress in the blood pump exceeds a threshold, which in turn triggers hemolysis in the patient. The impeller design of centrifugal blood pumps significantly influences the hydraulic characteristics and hemolytic properties of these devices. Based on this premise, the present study employs a multiphase flow approach to numerically simulate centrifugal blood pumps, investigating the performance of pumps with varying numbers of blades and blade deflection angles. This analysis encompassed the examination of flow field characteristics, hydraulic performance, and hemolytic potential. Numerical results indicated that the concentration of red blood cells and elevated shear stresses primarily occurred at the impeller and volute tongue, which drastically increased the risk of hemolysis in these areas. It was found that increasing the number of blades within a certain range enhanced the hydraulic performance of the pump but also raised the potential for hemolysis. Moreover, augmenting the blade deflection angle could improve the hemolytic performance, particularly in pumps with a higher number of blades. The findings from this study can provide valuable insights for the structural improvement and performance enhancement of centrifugal blood pumps.
The death of a loved one has physical, psychological, and social consequences. Between 9.8 and 21.5% of people who lose a loved one develop Prolonged Grief Disorder (PGD). Internet- and computer-based interventions (i.e., Internet-delivered Cognitive-Behavioral Therapy, iCBT) are cost-effective and scalable alternatives that make it possible to reach more people with PGD. The main goal of the present investigation was to examine the effect and feasibility (usability and satisfaction) of an iCBT (GROw program) for adults with PGD. A secondary objective was to detect adherence to the app (Emotional Monitor) used to measure daily grief symptoms. The study had a single-case multiple-baseline AB design with six participants. The GROw program is organized sequentially in eight modules, and it is based on the dual-process model of coping with bereavement. Evaluations included a pre-to-post treatment assessment of depression, grief symptoms, and typical grief beliefs, along with daily measures of symptom frequency and intensity on the Emotional Monitor App. Treatment opinions and adherence to the App were also collected. Efficacy data were calculated using a Nonoverlap of All Pairs (NAP) analysis and Reliable Change Index (RCI).
The present invention relates to a blood sugar measurement/management system capable of performing the ICT-based bidirectional communication, which is to collect blood sugar data and send the data to a server, and the user management. The blood sugar measurement/management system is capable of performing the ICT-based bidirectional communication and the user management sends the measured blood sugar data to a gateway through the Bluetooth low energy (BLE), a wireless communication method, and the gateway transmits the data to a service platform through the LTE communication, which is a wireless communication method, or the Ethernet communication, which is a wired communication method. The service platform integrates the blood sugar data received from the gateway with the previously stored data, and draws a message for response by analyzing the presence or absence of a disorder in the data, the figures, or the like. The drawn message is transmitted to a blood sugar gauge adapter through the gateway. The blood sugar gauge adapter analyzes the received response message, and indicates the results on an LED indicator, thereby sending the measured blood sugar data to the server to store the data, and allowing the person in charge of measurement to receive the results of the analysis by the server in real time. Accordingly, the present invention is able to let the person in charge of measurement know changes in the blood sugar levels, and make it easy to take care of the health.
Overactive bladder (OAB) is a common and often debilitating condition in both men and women. OAB symptoms including urinary frequency, urgency, and/or urge incontinence (UI), have been found to negatively impact quality of life. Due to side effects and the lack of patient compliance to pharmacologic treatments for OAB, non-pharmacologic treatments are in high demand for this condition. Neuromodulation therapies have become increasingly popular for the treatment of overactive bladder in men and women. These neuromodulation therapies work in treating OAB by stimulating the pudendal nerve. The BTL EmsellaTM (Emsella Chair) is a conservative neuromodulation therapy that may have a role for patients who are not surgical candidates or who desire a noninvasive treatment option. The ideal treatment for OAB is still lacking. Many patients are interested in pursuing conservative treatment options. The Emsella chair may have a role for patient who do not desire surgery found with SNM or desire a noninvasive treatment option.

The Emsella chair is approved as a treatment for stress urinary incontinence (SUI). Overactive bladder patients may benefit from treatment. The Emsella chair generates electromagnetic stimulation which is able to penetrate deep into the pelvic floor muscles inducing stimulation and providing rehabilitation for weak pelvic floor muscles. The Emsella chair is a novel high-intensity focused electromagnetic (HIFEM) technology for the treatment of SUI, in addition to other pelvic floor related disorders. HIFEM technology induces deep pelvic floor muscle contractions designed to deliver the equivalent of 11,200 Kegel exercises over 28 minutes.
MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders which had lost tumorigenesis. Sequencing of the mutant mouse genomes identified the Ring Finger Protein 121 (RNF121WT) gene mutated to RNFM158R associated with heritable loss of tumorigenicity. While the RNF121WT protein localised predominantly to the cis-Golgi Complex, the RNF121M158R mutation in Helix 4 of its transmembrane domain caused reduced RNF121 protein stability and absent Golgi localisation. RNF121WT expression markedly increased during TH-MYCN tumorigenesis, whereas hemizygous RNF121WT gene deletion reduced TH-MYCN tumorigenicity. The RNF121WT-enhanced growth of MYCN-amplified neuroblastoma cells depended on RNF121WT transmembrane Helix 5. RNF121WT directly bound MYCN protein and enhanced its stability. High RNF121 mRNA expression associated with poor prognosis in human neuroblastoma tissues and another MYC-driven malignancy, laryngeal cancer. RNF121 is thus an essential oncogenic cofactor for MYCN and a target for drug development.
The goal of this study is to test the effects of interventions informed by behavioral economics on the healthfulness of grocery purchases among diabetic adults. This study has a 3-group experimental design; adult patients with diabetes or at risk for diabetes who typically grocery shop in-person will be randomly assigned to one of two interventions or a control group. In all groups, recipe cards that follow the evidence-based DASH diet and correspond to dietary recommendations for diabetic patients will be provided. In addition, the first intervention, Online, will utilize online grocery shopping at a local grocery store to promote healthier purchasing, with a goal of removing visceral factors that can lead to impulse purchases in stores. The second intervention, Defaults, will augment the Online intervention, showing participants a default shopping cart when they log into their accounts. They will be told that their cart has been filled with items that conform to a diabetic diet and can be used to make the recipes from the provided recipe cards, and that they may modify their carts as they like. In the control group, participants will shop in-person as usual.

At baseline, all participants will complete a survey online or via phone and then will grocery shop in-person as usual. Participants will then be randomized and receive further instructions. For the next 3 weeks, they will receive recipe cards and shop in accordance with their assigned study group. The following week (post), they will grocery shop using the mode of their choice (in-person or online) and complete a survey again. Household receipt data will be collected throughout the study. The baseline period will also serve as a run-in period, and participants whose diabetes/prediabetes status is not confirmed by a physician or who do not comply with study guidelines for baseline procedures will not be randomized for further participation. Primary analyses will examine intervention effects on grocery purchases, with additional analyses examining spending and dietary intake. All participant interactions will occur online or via phone, with cards for participant payment sent via postal mail.

The specific aims of this study are: (1) to test effects of Online and Defaults interventions on diabetic adults' grocery purchases and (2) to explore effects of the Online and Defaults interventions on participants' spending during grocery shopping. It is hypothesized that (1a) purchases made by adults in the Defaults group will be lower in calories, carbohydrates, and sugar and higher in nutritional quality (DASH diet score) at post-test versus other study groups, (1b) adults in the Defaults group will show the greatest increases in nutritional quality versus other study groups, (1c) the Online group will have intermediary results between Defaults and Controls, and (2) there will be no difference in total dollars depicted on receipts across study groups during the intervention period (i.e. the costs of online shopping will be offset by effects of the Online and Default interventions).
The citrate levels in the bone start to decrease after death. Therefore, it may be possible to estimate the post-mortem interval if the citrate content decreases at regular and predictable intervals. To verify this, it was used twelve fresh porcine tibiae and femora, fifteen recently buried porcine bones, two samples of human bones curated from the anatomical teaching collection from Bournemouth University, UK (never been buried) and fifteen samples of archaeological human bones from Saint Augustine the Less, Bristol, UK. The results obtained in this study align together with the data available in the literature, with higher citrate content in the fresh porcine bones and lower in the archaeological samples, however, a statistical significance was not found. Moreover, the formula used to estimate the time since death largely overestimated the known PMI. Further research should be done with a larger sample and a new formula to estimate the post-mortem interval is required.
Crash risks are highest right after licensure and decline rapidly for about 6 months and then gradually for years, regardless of the amount of supervised practice driving or age at licensure. Graduate Driver Licensing (GDL) and parental management are the only approaches to this problem with demonstrated effectiveness. The Checkpoints Program consists of persuasive messages and materials designed to increase adoption of the Checkpoints Parent-Teen Driving Agreement and increase parent limit setting on higher-risk driving privileges among novice teenage drivers. The current study builds on the results of several previous trials of the Checkpoints Program that have shown significant treatment group effects on parent limit setting, teen risky driving, and violations. The purpose of this study is to determine the efficacy of conducting an online adaptation of the Checkpoints Program through the American Automobile Association (AAA) clubs. The study will be conducted with parents whose teenage children are enrolled in AAA-affiliated driving schools. 800 families will be recruited through AAA Clubs, assigned to intervention or comparison groups, provided online access to Checkpoints or comparison materials, and assessed at baseline and after teen licensure.
The invention relates to the field of medicines, and particularly relates to application of crocodile flower in preparation of a medicine for treating or preventing nerve injury and a medicine. Application of crocodile flower in preparing medicine for treating or preventing nerve injury caused by Parkinson's disease, Alzheimer's disease, cerebral apoplexy and tauopathy. A medicament for the preparation of a neuroprotective agent comprising alligator flower. The crocodile mouth flower has therapeutic effect on gradual degeneration and apoptosis of central neuron. The extract or drug of crocodile flower has effects of protecting neuron injury, thereby preventing or delaying nerve cell death; can delay the onset time or delay the development of the disease. The medicine prepared from crocodile flower can keep cells in healthy shape and proliferation and inhibit apoptosis; the medicine has remarkable protective effect on nerve cells.
Zovia 1/35: Each pale pink Zovia 1/35 tablet is round, biconvex, unscored, debossed with X1 on one side and contains 1 mg of ethynodiol diacetate and 35 mcg of ethinyl estradiol.

Zovia 1/35 is packaged in cartons of three (NDC 51862-894-03) and six (NDC 51862-894-06) tablet compact dispensers. Each compact dispenser contains 21 pale pink tablets and 7 white placebo tablets. Placebo tablets are round, biconvex and have a debossed P on one side and N on the other side.

Store at 20° to 25°C (68° to 77°F). [See USP controlled room temperature.]
PCT No. PCT/GB95/02485 Sec. 371 Date Jul. 18, 1996 Sec. 102(e) Date Jul. 18, 1996 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/13251 PCT Pub. Date May 9, 1996Process for preparing an oral rapidly disintegrating dosage form of a hydrophobic pharmaceutically active substance comprising forming a suspension of the hydrophobic pharmaceutically active substance in a solvent containing a pharmaceutically acceptable surfactant together with a water-soluble or water-dispersible carrier material, forming discrete units of the suspension and removing solvent from the discrete units under conditions whereby a network of the carrier material carrying a dosage of the hydrophobic pharmaceutically active substance is formed.
PURPOSE:The titled suppository drug useful for remedying acute and chronic hepatitis, promoting absorption of interferon form the mucosa of the colon and the rectum, containing a ursodeoxycholate and interferon. CONSTITUTION:A suppository preparation containing a ursodeoxycholate and interferon (IFN for short). If bioavailability of IFN in the liver can be improved by promoting absorption of IFN from the mucosa of the colon and the rectum, IFN can be used as an antiviral agent and an immune adjunct in remedy of acute or chronic hepatitis. When IFN is blended with the ursodeoxycholate and administered to the rectum, clear increase in IFN plasma level is observed. In rectum administration, there is possibility of IFN gradient in portal vein- peripheral blood vessel, therefore IFN concentration of blood flow volume of the liver is raised, to improve remedying effects on hepatitis. The concentration of ursodeoxycholate is 600-900mg/weight.
To provide methods and compositions for dissolving or solubilizing therapeutic agents.SOLUTION: The invention provides pharmaceutical compositions comprising a dry medicament. The dry medicaments can be rapidly dissolved, solubilized, and/or reconstituted to be delivered to a subject. The present invention provides methods of preparing a medical solution. The medical solution can be prepared by mixing a pharmaceutical composition as described herein with a first liquid. In some embodiments, a dry pharmaceutical composition comprises a combination of a dry medicament and one or more dry pH adjusting agents. In some embodiments, the dry pharmaceutical composition can be reconstituted into a solution by mixing the dry pharmaceutical composition with a first solution. In some embodiments, the first solution has a pH that rapidly dissolves the dry medicament.SELECTED DRAWING: None
INTRODUCTION: Osteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration.
METHODS: This study focuses on Songorine, derived from Aconitum soongaricum Stapf, aiming to unravel its therapeutic mechanisms in OA. Comprehensive analyses, including PCR, Western blot, and immunofluorescence, were employed to evaluate Songorine's impact on the joint microenvironment and macrophage polarization. RNA-seq analysis was conducted to unravel its anti-inflammatory mechanisms in macrophages. Metabolic alterations were explored through extracellular acidification rate monitoring, molecular docking simulations, and PCR assays. Oxygen consumption rate measurements were used to assess mitochondrial oxidative phosphorylation, and Songorine's influence on macrophage oxidative stress was evaluated through gene expression and ROS assays.
RESULTS: Songorine effectively shifted macrophage polarization from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype. Notably, Songorine induced metabolic reprogramming, inhibiting glycolysis and promoting mitochondrial oxidative phosphorylation. This metabolic shift correlated with a reduction in macrophage oxidative stress, highlighting Songorine's potential as an oxidative stress inhibitor.
DISCUSSION: In an in vivo rat model of OA, Songorine exhibited protective effects against cartilage damage and synovial inflammation, emphasizing its therapeutic potential. This comprehensive study elucidates Songorine's multifaceted impact on macrophage modulation, metabolic reprogramming, and the inflammatory microenvironment, providing a theoretical foundation for its therapeutic potential in OA.