anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Spring viremia of carp virus (SVCV) has a broad fish host spectrum and is responsible for a disease that generally affects juvenile fishes with a mortality rate of up to 90%. In the absence of treatments or vaccines against SVCV, the search for prophylactic or therapeutic solutions is thus relevant, particularly to identify solutions compatible with mass vaccination. In addition to being a threat to aquaculture and ecosystems, SVCV is a unique pathogen to study virus-host interactions in the zebrafish model. Establishing the first reverse genetics system for SVCV and the design of recombinant SVCV (rSVCV) expressing fluorescent or bioluminescent proteins adds a new dimension for the study of these interactions using innovative imaging techniques. The infection by bath immersion of zebrafish larvae with rSVCV expressing mCherry allows us to define the first SVCV replication sites and the host innate immune responses using different transgenic lines of zebrafish. The fins were found as the main initial sites of infection in both zebrafish and carp, its natural host. Hence, new insights into the physiopathology of SVCV infection have been described. We report that neutrophils are recruited at the sites of infection and persist up to the death of the animal leading to an uncontrolled inflammation correlated with the expression of the pro-inflammatory cytokine IL1β. Tissue damage was observed at the site of initial replication, a likely consequence of virus-induced injury or the pro-inflammatory response. Interestingly, SVCV infection by bath immersion triggers a persistent pro-inflammatory response rather than activation of the antiviral IFN signaling pathway as observed following intravenous injection, highlighting the importance of the route of infection on the progression of pathogenicity. Thus, this model of zebrafish larvae infection by rSVCV offers new perspectives to study in detail virus-host interactions and to discover new prophylactic or therapeutic solutions.
Background: The current study was a preliminary investigation of Live FREE, a pilot study of a treatment that included a combination of Dialectical Behavioral Therapy (DBT) and Behavioral Weight Loss (BWL) techniques for overweight/obese adult emotional eaters. Live FREE was based on the premise that impaired emotion regulation skills promote emotional eating behavior and lead to weight gain. Consistent with the ORBIT model (Czajkowski et al., 2015) of behavioral treatment development, the primary study aim was to refine the treatment protocol.

Methods: Adults with overweight/obesity who self-identified as emotional eaters were enrolled in Live FREE. Participants completed assessments at baseline, post-treatment, and at a 6-month follow-up. The intervention delivered 10-weeks of emotion regulation skills training followed by 6-weeks of BWL treatment in a group-based format. Groups were co-led by a licensed clinical psychologist and a doctoral student. Feasibility and acceptability will be examined by calculating rate of enrollment into the study and session attendance. ANOVA will be used to examine changes in primary and secondary outcome variables (weight, emotional eating) over time. Effect sizes (Cohen's d) will be calculated to examine the magnitude of change observed in these outcomes using standard interpretation guidelines ( d=0.2 be considered a 'small' effect size, 0.5 represents a 'medium' effect size and 0.8 a 'large' effect size).
Participants will meet with a therapist for group therapy once a week for eight weeks. Each weekly session will last approximately 50 minutes. During these weekly sessions, the therapist will educate participants about health and mental health.
Excessive insulin secretion independent of insulin resistance, defined as primary hypersecretion, is associated with obesity and an unfavorable metabolic phenotype. We examined the characteristics of adipose tissue of youth with primary insulin hypersecretion and the longitudinal metabolic alterations influenced by the complex adipo-insular interplay. In a multiethnic cohort of adolescents with obesity but without diabetes, primary insulin hypersecretors had enhanced model-derived β-cell glucose sensitivity and rate sensitivity but worse glucose tolerance, despite similar demographics, adiposity, and insulin resistance measured by both oral glucose tolerance test and euglycemic-hyperinsulinemic clamp. Hypersecretors had greater intrahepatic and visceral fat depots at abdominal MRI, hypertrophic abdominal subcutaneous adipocytes, higher free fatty acid and leptin serum levels per fat mass, and faster in vivo lipid turnover assessed by a long-term 2H2O labeling protocol. At 2-year follow-up, hypersecretors had greater fat accrual and a threefold higher risk for abnormal glucose tolerance, while individuals with hypertrophic adipocytes or higher leptin levels showed enhanced β-cell glucose sensitivity. Primary insulin hypersecretion is associated with marked alterations in adipose tissue distribution, cellularity, and lipid dynamics, independent of whole-body adiposity and insulin resistance. Pathogenetic insight into the metabolic crosstalk between β-cell and adipocyte may help to identify individuals at risk for chronic hyperinsulinemia, body weight gain, and glucose intolerance.
Aqueous gel and gel-containing compositions comprises hydrophilic gelling agent and polyethylene glycol.  The gel comprises (i) at least one hydrophilic gelling agent and (ii) at least one polyethylene glycol with a number of oxyethylene units of 12-180. The hydrophilic gelling agent is present in amount 0.1-30 (especially 0.2-10) wt.% per total weight of the gel, and is selected from polysaccharides, protein derivatives, synthesis or hemisynthesis gels of polyester type, especially sulfonic, polyacrylates or polymethacrylates, and their derivatives. Polyethylene glycol is present in amount 1-20 (preferably 2-10) wt.% per total weight of gel. The gel preferably also contains a powdered phase comprising pigment, mother-of-pearl and/or filler. Pigments can be of mineral or organic type while the mother-of-pearl can be natural, of mica/titania type, iron oxide, natural pearl pigment or bismuth oxychloride as well as colored mica titanium, and they are present in the gel in amount up to 40 wt.%, (preferably 0.1-30 wt.%)  each. Fillers can be of mineral, organic or polymeric type, or they may be in form of glass or ceramic microcapsules, and they are present in the gel in an amount up to 60 wt.%, (preferably 0.1-40wt.%) per total weight of the gel. The gel may also contain salt, a water-soluble colorant of a cosmetically or physiologically acceptable medium, and a solvent, as well as additional compounds selected from antioxidants, essential oils, preservatives, lipophilic or hydrophilic active substances of cosmetic or pharmaceutical type, hydration agents, vitamins, essential fatty acids, sphingolipids, self-tanning compounds, solar filters, fragrances and their mixtures. Independent claims are also included for 1) a solid composition with continuous aqueous phase, comprising gel as claimed; 2) cosmetic make-up product, comprising gel as claimed and/or composition as claimed, for skin, keratin fibers and mucous membranes; and 3) the process of make-up of skin and/or keratin fibres, comprising application of gel and/or composition and/or product as claimed.
The main objective of this prospective cohort study is to know the correlation between pre- operative Bethesda with post- operative histopathology , pre - operative TIRADS with post operative Histopathology and comparison of combined scoring of Bethesda and TIRADS with histopathology report. It is of utmost importance to deep dive into thyroid nodules workup to detect malignant nodules, as the management aspect of benign and malignant nodules has a vast difference. Thyroid ultrasonography is useful for risk stratification of nodules, and American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) classification provides recommendations for fine-needle aspiration cytology (FNAC) based on objective ultrasonography features of these nodules. To maintain uniformity in reporting system FNA sample are categorized according to the Bethesda system. Total 42 participants who met the inclusion criteria were included in the study. Statistical Analysis was done using Statistical Package for the Social Science (SPSS) version 25. Analysis was done in the form of percentage and proportion and represented as table wherever necessary. Spearman's correlation coefficient was used to evaluate the correlation between Bethesda and TIRADS. Bethesda and histopathology and TIRADS and Bethesda system. The P value was set at \< 0.05 for statistical significance.
The vial of meplazumab will be reconstituted with 1 mL of water for injection. The required amount of drug solution will be withdrawn and added to 100 mL sterile normal saline (0.9%) for IV infusion. A single dose of meplazumab will be infused over 60 minutes at a constant rate using an infusion pump.
BACKGROUND: Pineal tumors are rare, and the pineal region is a challenging surgical location for neurosurgeons. The present study aimed to investigate the effects of microsurgical management in patients with pineal region tumors and explore probable factors associated with preoperative hydrocephalus, postoperative hydrocephalus remission, and prolonged hospital length of stay (LoS).
METHODS: A retrospective study of patients with pineal region tumors who underwent microsurgical management at the First Affiliated Hospital of Soochow University (Jiangsu, China) between 1 January 2010 and 31 October 2022 was conducted.
RESULTS: Data from 36 patients were included in this study. The top 5 common symptoms included headache (58%), dizziness (44%), double vision (22%), vomiting (19%), and nausea (14%). Patients with a lower Karnofsky Performance Score (KPS), younger age, and larger maximum tumor diameters were more vulnerable to preoperative hydrocephalus. Preoperative hydrocephalus also led to a prolonged postoperative LoS (P = 0.021). Patients with a lower KPS score (P = 0.020) or larger maximum tumor diameters (P = 0.045) were more likely to achieve postoperative remission of hydrocephalus. Most postoperative complications led to increased hospital LoS.
CONCLUSIONS: Microsurgical resection of pineal tumors yielded favorable long-term outcomes. Patients with a lower KPS score, younger age, and larger maximum tumor diameters were more vulnerable to preoperative hydrocephalus and prolonged LoS. Patients with a lower KPS score or larger tumor diameter were likely to achieve significant remission of hydrocephalus after tumor resection.
No dose adjustment to FANAPT is needed in patients with mild hepatic impairment. Exercise caution when administering it to patients with moderate hepatic impairment. FANAPT is not recommended for patients with severe hepatic impairment [see Dosage in Special Populations (2.2)].

In adult subjects with mild hepatic impairment no relevant difference in pharmacokinetics of iloperidone, P88 or P95 (total or unbound) was observed compared to healthy adult controls. In subjects with moderate hepatic impairment a higher (2-fold) and more variable free exposure to the active metabolites P88 was observed compared to healthy controls, whereas exposure to iloperidone and P95 was generally similar (less than 50% change compared to control). Since a study in severe liver impaired subjects has not been conducted, FANAPT is not recommended for patients with severe hepatic impairment.
The effects of the interaction between polygenes and the parent-child relationship on junior high school students' aggressive behaviors were explored through the frameworks of gene-endophenotype-behavior and neurophysiological basis. A total of 892 junior high school students participated in this study. They were asked to complete self-reported questionnaires, and saliva samples were collected. Results showed that 5-HTTLPR, MAOA-uVNTR, COMT (rs4680), and Taq1 (rs1800497) of the DRD2 gene affected students' aggressive behaviors in an accumulative way. The polygenic risk score explained 3.4% of boys' aggression and 1.1% of girls' aggression. The interactions between polygenic risk score and parent-child conflict significantly affected the aggressive behaviors of male students, but did not show any significant effect on those of female students. The interactional effect of polygenic risk score and parent-child conflict on junior high school students' aggressive behaviors was completely mediated by frustration. However, the interaction effect of polygenic risk score and parent-child affinity on aggression was not affected by frustration. This study helps us better understand junior high school students' aggressive behaviors and promotes the prevention and correction of adolescents' problem behaviors.
This group will be getting all the routine work up including Duplex scan . we will add request for inflammatory and coagulation markers in their blood samples before and after intervention . The pre-op blood sample will be collected within the 24 hours before intervention and the post intervention in the 24 hrs after (second RIPC window). The repeated duplex scan will be schedule after 6 months.
PURPOSE:To obtain an active amino acid calcium salt, excellent in bone resorption and bone deposition nature, useful as a nutrient auxiliary food with coexisting amino acid(s), etc., by heating a natural calcium ingredient-contg. substance at temperatures within a specified range under an oxygen-blocking condition followed by forced cooling. CONSTITUTION:A natural calcium ingredient-contg. substance such as washed oystershell is heated through electric current injection at 800-980 deg.C for 20-120min in a relevant hot oven 7 under an oxygen-blocking condition followed by forced cooling, thus obtaining the objective active amino acid calcium salt where amino acid(s) such as cystine coexist with natural calcium oxide and/or calcium hydroxide. The proportion of the coexistent amino acid(s) is pref. 0.01-5wt.% of the whole active amino acid calcium salt. The other objective beverage containing the active amino acid calcium salt can be obtained by dissolving said salt in an aqueous fermented lactic acid solution.
FIELD: microbiology. SUBSTANCE: method involves the selection of Salmonella strains showing broad spectrum of H-antigenes and with minimal O-antigens content. From 18 selected strains antigen is prepared that is isolated flagella. Rabbits were immunized with prepared antigen by two cycles and genus-specific polyvalent H-serum with titer (1:3200)-(1:12800) at dilution 1: 320 is obtained. Serum ensures to detect salmonellae at amount one cell per 50 g analyzed product and in mixed culture also without biochemical testing. Salmonella indication is carried out in agglutination reaction. Method is used for diagnosis. EFFECT: improved method of H-serum preparing. 6 tbl
In the search for mechanisms that contribute to dyslexia, the term "attention" has been invoked to explain performance in a variety of tasks, creating confusion since all tasks do, indeed, demand "attention." Many studies lack an experimental manipulation of attention that would be necessary to determine its influence on task performance. Nonetheless, an emerging view is that children with dyslexia have an impairment in the exogenous (automatic/reflexive) orienting of spatial attention. Here we investigated the link between exogenous attention and reading ability by presenting exogenous spatial cues in the multi-letter processing task-a task relevant for reading. The task was gamified and administered online to a large sample of children (N = 187) between 6 and 17 years. Children with dyslexia performed worse overall at rapidly recognizing and reporting strings of letters. However, we found no evidence for a difference in the utilization of exogenous spatial cues, resolving two decades of ambiguity in the field. Previous studies that claimed otherwise may have failed to distinguish attention effects from overall task performance or found spurious group differences in small samples. RESEARCH HIGHLIGHTS: We manipulated exogenous visual spatial attention using pre-cues in a task that is relevant for reading and we see robust task effects of exogenous attention. We found no evidence for a deficit in utilizing exogenous spatial pre-cues in children with dyslexia. However, children with dyslexia showed reduced recognition ability for all letter positions. Children with dyslexia were just as likely to make letter transposition errors as typical readers.
The invention discloses a processing method and application of pearl barley. The processing method of the coix seed comprises the following steps: (1) removing bract of fresh Coicis semen, soaking in tea polyphenols water solution at room temperature for 0.5-3 hr, and taking out; (2) parching with sand until the surface is yellow, slightly swelling, taking out, and cooling. In the step (1), the weight percentage concentration of the tea polyphenol is 0.01-0.02%, and the pH value is 5.5-6.8. In the step (2), the sand stir-frying is firstly carried out for 15-25min at the low temperature of 80-100 ℃ by small fire, and then carried out for 15-25min at the temperature of 120-130 ℃ by medium fire, and the stir-frying process is continuously carried out. By adopting the method, the tea polyphenol is slowly attached to the surface of the coix seed or infiltrates into the tissue of the coix seed, so that the oxidation of the coix seed in the processing process can be prevented, the occurrence of rancid flavor is avoided, the storage period of the coix seed is effectively prolonged, and the coix seed has the faint scent of tea leaves. The coix seed processed by the method can be used as a raw material of food, medicines or drinks.
PURPOSE:To titled method wherein a protein solution is blended with specific gel for gel filtration carrier and a solution component is recovered from the blend. CONSTITUTION:A protein as a starting raw material is dissolved in >=0.1mM phosphoric acid buffer solution at 6-10pH to prepare a protein solution. Whey protein, casein, soybean protein, etc., may be cited as the protein. The prepared protein solution is blended with gel for gel filtration carrier, having 1,000-5,000 dalton molecular weight fraction. The amount of the solution is preferably adjusted to 150-300ml based on 1l of the gel while stirring. The blend is allowed to stand or centrifuged and its supernatant liquid is separated, to give a solution component. EFFECT:Specific amino acids such as phenylalanine, methionine, etc., can be effectively removed in a short time and this process is useful for producing protein food ingredients for patients of inborn error of metabolism to amino acids.
OBJECTIVE: Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity is critical for assessing future interventions. We used data from a large, prospective surveillance study to assess risk factors associated with severe presentation using modified Vesikari score (MVS) and Clark score (CS) of severity.
METHODS: From December 1, 2012 to June 30, 2016, AGE surveillance was performed for children between 15 days and 17 years old in the emergency, inpatient, and outpatient settings at Vanderbilt's Monroe Carell Jr. Children's Hospital in Nashville, TN. Stool specimens were tested for norovirus, sapovirus, rotavirus, and astrovirus. We compared demographic and clinical characteristics, along with the MVS and CS, by viral detection status and by setting.
RESULTS: Of the 6309 eligible children, 4216 (67%) were enrolled, with 3256 (77%) providing a stool specimen. The median age was 1.9 years, 52% were male, and 1387 (43%) of the stool samples were virus positive. Younger age, male sex, hospitalization, and rotavirus detection were significantly associated with higher mean MVS and CS. Non-Hispanic Black race and ethnicity was associated with a lower mean MVS and CS as compared with non-Hispanic white race and ethnicity. Prematurity and enrollment in the ED were associated with higher mean CS. The 2 scoring systems were highly correlated.
CONCLUSIONS: Rotavirus continues to be associated with more severe pediatric illness compared with other viral causes of AGE. MVS and CS systems yielded comparable results and can be useful tools to assess AGE severity.
At present, endoscopic therapy is the preferred method to solve biliary or pancreatic diseases. And EUS-guided stent implantation and drainage of pancreatic pseudocyst is the main method in Endoscopic treatment of pancreatic pseudocyst. However, blockage of stent is a problem that has puzzled endoscopists for a long time. The mechanism of stent blockage is related to the reflux of gastrointestinal contents into the stent. Although plastic stents are widely used in patients who needed drainage. However, the average free time for stent is only 77 to 126 days, leading to the need for stent replacement in most patients within 3 months. As one end of the double pigtail stent used for drainage of pancreatic pseudocyst may be located in the stomach, it may cause the stent to be blocked by the contents of the stomach. Therefore, multiple stents or additional stents or drainage tube are often needed to further strengthen the drainage.

It seems that the mechanism of stent blockage are associated with gastrointestinal contents reflux. And stents required be replaced again by endoscopic approach when jamming. However, EUS and ERCP are difficult, costly, and may be with complications. Additional operations will increase the risks and costs. Therefore, a stent that can effectively prevent reflux, solve clinical problems, and effectively prolong stent patency time is urgently needed.

The extended enteral anti-reflux stent developed by our research team has potential advantages in prolonging the patency period of the stent and preventing secondary infection of pseudocysts. In this study, we aim to evaluate the effect of the stent on the drainage of pancreatic pseudocyst.
Ga-68 PSMA PET/CT imaging is now routinely done in patients with prostate cancer with biochemical recurrence, response evaluation and even in patients with clinical suspicion of prostate cancer. In the present study, we aim to plan robotic arm-assisted Ga-68 PSMA guided transgluteal prostatic biopsies.
FIELD: medicine, veterinary science, antibiotics, polymers. SUBSTANCE: invention relates to polymeric combination of antibiotics. Polymeric component of proposed composition represents homogenous polymeric mixture consisting of one or more hydrophobic polymers taken among the group of methacrylic acid polyesters, acrylic acid polyesters, methacrylic acid esters and acrylic acid esters copolymers and one or more hydrophilic polymers taken among the group of polyethers. One or more slightly water-soluble antibiotics among the group of aminoglycoside, lincosamide, tetracycline and quinolone antibiotics are suspended in indicated polymeric mixture. If necessary, easily water-soluble antibiotic taken among the group of aminoglycoside, lincosamide and tetracycline antibiotics is added to the mixture and, if necessary, organic medicinal accessory substance is added also. The content of hydrophilic polymer in the homogenous polymeric mixture is from 0.1 to 60 wt. -%. Under physiological conditions the polymeric antibiotic composite provides continuous releasing antibiotics for period from some days to some weeks and it is useful for applying on surfaces of medicinal synthetic and metallic implants and provides strong adhesion also. The polymeric antibiotic composite can be used for preparing threads, films and mould articles. EFFECT: improved preparing method, valuable properties of combination. 24 cl, 1 tbl, 6 ex