anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject formulation exhibiting excellent sustained release property and readily controlling releasing rate even in processed to a preparing form of readily administrable granules, etc., by cooling and pelletizing a uniform solution obtained by heat-melting of an active component, a cellulosic derivative and a hardened oil. SOLUTION: (A) An active component, (B) a cellulosic derivative (e.g.; ethyl cellulose or hydroxypropylmethyl cellulose) and (C) a hardened oil (e.g.; a hardened rape seed oil or a hardened soybean oil) are heat-melted by usually using a solvent such as alcohols to obtain a uniform solution, and the solution is cooled and pelletized. As the component A, a medicine necessary for avoiding abrupt rising of concentration in blood because of having a strong adverse effect, such as a thiazide-based depressor or a salicylic acid derivative-based antipyretic analgesic and antiphlogistic agent is preferable. A mixing ratio of each component in the objective formulation is preferably 10-50wt.%, 20-50wt.% and 20-60wt.% for the components A, B and C, respectively. An amount of the solvent is enough for a minimum amount to dissolve the components A and B.
BACKGROUND AND OBJECTIVE: Sudden cardiac death (SCD) is a critical health issue characterized by the sudden failure of heart function, often caused by ventricular fibrillation (VF). Early prediction of SCD is crucial to enable timely interventions. However, current methods predict SCD only a few minutes before its onset, limiting intervention time. This study aims to develop a deep learning-based model for the early prediction of SCD using electrocardiography (ECG) signals.
METHODS: A multimodal explainable deep learning-based model is developed to analyze ECG signals at discrete intervals ranging from 5 to 30 min before SCD onset. The raw ECG signals, 2D scalograms generated through wavelet transform and 2D Hilbert spectrum generated through Hilbert-Huang transform (HHT) of ECG signals were applied to multiple deep learning algorithms. For raw ECG, a combination of 1D-convolutional neural networks (1D-CNN) and long short-term memory networks were employed for feature extraction and temporal pattern recognition. Besides, to extract and analyze features from scalograms and Hilbert spectra, Vision Transformer (ViT) and 2D-CNN have been used.
RESULTS: The developed model achieved high performance, with accuracy, precision, recall and F1-score of 98.81%, 98.83%, 98.81%, and 98.81% respectively to predict SCD onset 30 min in advance. Further, the proposed model can accurately classify SCD patients and normal controls with 100% accuracy. Thus, the proposed method outperforms the existing state-of-the-art methods.
CONCLUSIONS: The developed model is capable of capturing diverse patterns on ECG signals recorded at multiple discrete time intervals (at 5-minute increments from 5 min to 30 min) prior to SCD onset that could discriminate for SCD. The proposed model significantly improves early SCD prediction, providing a valuable tool for continuous ECG monitoring in high-risk patients.
PURPOSE: Literature evidence suggests that trabectedin monotherapy is effective in patients with recurrent ovarian cancer (OC) presenting BRCA mutation and/or BRCAness phenotype.
METHODS: A prospective, open-label, randomized phase III MITO-23 trial evaluated the activity and safety of trabectedin 1.3 mg/m2 given once every 3 weeks (arm A) in BRCA 1/2 mutation carriers or patients with BRCAness phenotype (ie, patients who responded to ≥two previous platinum-based treatments) with recurrent OC, primary peritoneal carcinoma, or fallopian tube cancer in comparison with physician's choice chemotherapy in the control arm (arm B; pegylated liposomal doxorubicin, topotecan, gemcitabine, once-weekly paclitaxel, or carboplatin). The primary end point was overall survival (OS) evaluated in the intention-to-treat population.
RESULTS: Overall, 244 patients from 21 MITO centers were randomly assigned (arm A = 122/arm B = 122). More than 70% of patients received ≥three previous chemotherapy lines and 35.7% had received a poly (ADP-ribose) polymerase inhibitor (PARPi) before enrollment. Median OS was not significantly different between the arms: arm A: 15.8 versus arm B: 17.9 months (P = .304). Median progression-free survival was 4.9 months in arm A versus 4.4 months in arm B (P = .897). Among 208 patients evaluable for efficacy, the objective response rate was 17.1% in arm A and 21.4% in arm B, with comparable median duration of response (5.62 v 5.66 months, respectively). No superior effect was observed for trabectedin in the prespecified subgroup analyses according to BRCA mutational status, chemotherapy type, and pretreatment with a PARPi and/or platinum-free interval. Trabectedin showed a higher frequency of grade ≥3 adverse events (AEs), serious AEs, and serious adverse drug reactions compared with control chemotherapy.
CONCLUSION: Trabectedin did not improve median OS and showed a worse safety profile in comparison with physician's choice control chemotherapy.
The present invention includes a method for targeted isolation, segmentation, and coloring of anatomic images, anatomic maps, points of interest, and regions of interest for dynamic, translated form generation. For example, this invention includes a method whereby a description of anatomy that includes an anatomic site, and optionally laterality and other descriptors, targets and isolates diagrams from an anatomic map library that fits the anatomy description. A point of interest on a layered, hierarchical map is visualized in relation to the borders of each isolated anatomic site above, below, on the same level along with translated human readable descriptions of the pin position relative to each layer. An anatomic region of interest is also visualized in relation to sites above, below, and on the same hierarchical or layer level. Targeted isolation of each layer provides visualization, translation, descriptions, and visual selection points for a visual, translated hierarchical travel method included in this invention. A dynamic anatomy library combines with other data to generate dynamically filled in and fillable forms with relevant visualizations, codes, translations, and data. Dynamic forms that contain anatomy data are processed through a form processing engine for detection, categorization, encoding, translation, and labeling of the anatomy and non-anatomy data, and those outputs then process through a billing code engine, record generation engine, and image and visualization labeling engine. A record retrieval engine applies neural networks, computer vision, and artificial intelligence to re-create, analyze, categorize, and serve back record defined data to complete the loop.
Limb salvage surgery is performed on sarcoma patients 4-6 week post radiotherapy. These patients will be randomized to receive 7 days of Incisional Negative pressure wound therapy.
Patients, 18 years or older, in surgical or oncological routine care in Helsingborg, Lund, Malmö or Kristianstad Hospitals. Patients are planned for surgical excision or cytological diagnostics (needle aspiration) of metastatic melanoma. Imaging of tumours will be applied before surgery. Blood samples are taken before surgery. Tumour biopsies will be taken and snap-frozen (-80°C) immediately after surgery. A baseline questionnaire about skin cancer risk factors, co-morbidities, phenotypic factors, diets, smoking, alcohol and quality of life will be given to the patient before surgery.
PURPOSE: A Ribes fasciculatum var. chinense extract is provided to alleviate dermatitis symptom, to reduce plasma IgE, and TNF-alpha and IL-6 in macrophage, to suppress histamine release, and to be used as a pharmaceutical composition or a health functional food for preventing or treating atopic dermatitis. CONSTITUTION: A pharmaceutical composition for preventing and treating atopic dermatitis contains a Ribes fasciculatum var. chinense extract as an active ingredient. The extract is prepared using water including purified water, C1-C4 low alcohol, or a mixture thereof. The extract is soluble in water or 50-90% ethanol. A health functional food for preventing and treating atopic dermatitis contains the extract as an active ingredient. The health functional food is manufactured in the form of a tablet, a capsule, a pill, or a liquid.
COLUMVI can cause serious and fatal neurologic toxicity, including Immune Effector Cell-Associated Neurotoxicity (ICANS) [see Adverse Reactions (6.1)].

Coadministration of COLUMVI with other products that cause dizziness or mental status changes may increase the risk of neurologic toxicity. Optimize concomitant medications and hydration to avoid dizziness or mental status changes. Institute fall precautions as appropriate.

Monitor patients for signs and symptoms of neurologic toxicity, evaluate, and provide supportive therapy; withhold or permanently discontinue COLUMVI based on severity [see Dosage and Administration (2.4)].

Evaluate patients who experience neurologic toxicity such as tremors, dizziness, or adverse reactions that may impair cognition or consciousness promptly, including potential neurology evaluation. Advise affected patients to refrain from driving and/or engaging in hazardous occupations or activities, such as operating heavy or potentially dangerous machinery, until the neurologic toxicity fully resolves.

In Study NP30179, among 145 patients who received COLUMVI, the most frequent neurologic toxicities of any grade were headache (10%), peripheral neuropathy (8%), dizziness or vertigo (7%), and mental status changes (4.8%, including confusional state, cognitive disorder, disorientation, somnolence, and delirium). Grade 3 or higher neurologic adverse reactions occurred in 2.1% of patients and included somnolence, delirium, and myelitis. Cases of ICANS of any grade occurred in 4.8% of patients.

In STARGLO, among 172 patients who received COLUMVI in combination with gemcitabine and oxaliplatin, the most frequent neurologic toxicities of any grade were peripheral neuropathy (37%), insomnia (12%), headache (9%), dizziness (7%), and dysgeusia (5%). Grade 3 or higher neurologic adverse reactions occurred in 6% of patients and included peripheral sensory neuropathy, syncope, extrapyramidal disorder, confusional state, delirium, herpes zoster, meningitis aseptic, subdural hematoma, and cerebral hemorrhage. Cases of ICANS of any grade occurred in 2.3% of patients.
BACKGROUND: Significant morbidity can arise from acute bacterial cholangitis. Key to improving outcomes is the implementation of aggressive antibiotic therapy and prompt biliary decompression through either endoscopic or percutaneous means. However, the challenge in treating these infections is amplified by the evolving patterns of antimicrobial resistance, particularly when determining the appropriate empiric therapy.
METHODS: The present study was conducted at Shifa International Hospital in Islamabad. The patients with the diagnosis of Acute bacterial cholangitis between July 2016 and June 2022 were included. Data was analyzed using SPSS-26.0 to identify any significant associations or correlations among the study variables.
RESULTS: A total of 144 patients with a diagnosis of acute bacterial cholangitis were included in the study. 51 of these patients had a positive blood culture. The most commonly identified organism was E. coli, followed by Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus, Enterococcus spp and others. Antibiotic sensitivity pattern revealed resistance to Ceftazidime in 87%, Piperacillin-Tazobactam in 63.7%, Ertapenem in 34.4%, Meropenem in 26.1%, Imipenem in 25.0% and Colistin in 16.1%.
CONCLUSIONS: A high resistance pattern for antibiotics was observed in our study. This might, in turn, represent the prior judicious use of antibiotics in our community hospitals before these patients are referred to a tertiary referral center.
OBJECTIVE: Sesamol (SES) is a phenolic compound found in sesame seed oil. Several studies have revealed its anti-inflammatory and antioxidant properties. However, its complete underlying mechanistic perspective about cerebral ischemia/reperfusion (I/R) lesions has not yet been disclosed. Consequently, we aimed to scrutinize its neuroprotective mechanism against cerebral injury during a global cerebral I/R in a rat model, considering its impact on autophagy and Notch1/NLRP3 inflammasome signaling regulation.
METHODS: To affirm our purpose, adult Wistar rats were allotted into five groups: sham and the other four groups in which transient global cerebral ischemia was induced by bilateral common ligation (2VO) for 1 h, then reperfusion for either 24 h or 5 days: I/R (1/24), I/R (1/5), SES + I/R (1/24), and SES + I/R (1/5). In treated groups, SES (100 mg/kg, p.o., for 21 days) was administered before cerebral I/R induction. The assessment of histopathological changes in brain tissues, immunohistochemistry, biochemical assays, ELISA, and qRT-PCR were utilized to investigate our hypothesis.
RESULTS: Advantageously, SES halted the structural neuronal damage with lessened demyelination induced by cerebral I/R injury. Restoring oxidant/antioxidant balance was evident by boosting the total antioxidant capacity and waning lipid peroxidation. Furthermore, SES reduced inflammatory and apoptosis markers. Additionally, SES recovered GFAP, Cx43, and autophagy signaling, which in turn switched off the Notch-1/NLRP3 inflammasome trajectory.
CONCLUSIONS: Our results revealed the neuroprotective effect of SES against cerebral I/R injury through alleviating injurious events and boosting autophagy, consequently abolishing Notch1/NLRP3 inflammasome signaling.
Participants receive gabapentin PO daily or TID. Participants may also receive methadone PO TID and oxycodone PO every 8 hours as needed. Treatment continues for up to 12 months in the absence of disease progression or unacceptable toxicity.
A smart mask includes a body including a passive NFC smart single-chip device (ISO14443/ISO18092 international standard protocol) that contains a passive powerless short-range wireless communication, and at least two hanging ears. The passive NFC smart single chip for short-range wireless communication without power supply (ISO14443/ISO18092 international standard protocol) is a short-range communication transmission technology. The transmitted information is encoded and loaded onto a high-frequency carrier signal, and then transmitted wirelessly through antenna induction. The passive NFC smart single chip for short-range wireless communication without power supply does not require power supply and can be placed at any position in the middle of the mask. With a light touch, it can be used to achieve a wireless, fast and safe connection with an NFC smart phone for information, data, Data reading and connection to the Internet to share and interact, and provide the only readable and unchangeable original internal code for the manufacturer for fake identification and authentication, and it can be read with another passive NFC smart single chip without power near field communication Write a billion body for users to record electronic ID cards and data, and connect to the Internet to achieve accurate analysis and shared tracking of artificial intelligence big data. The material of the mask body can be any one-time melt blown non-woven three-layer protection material, or it can meet the national standard NFC (CNS14774) (T5017) medical mask performance specifications and N95 masks. The main body includes two ear straps connected to opposite sides of the face ears, and each ear strap has an opening, thereby forming a smart mask.
PURPOSE: To provide a light-aging preventing agent having excellent stability and safety, exhibiting excellent light-aging preventing effect, effective for preventing and ameliorating wrinkles, sagging, etc., of the skin and useful for a skin cosmetic having excellent skin-beautifying effect. CONSTITUTION: This light-aging preventing agent contains hexahydrocurcumin of the formula as an active component. A skin cosmetic is produced by compounding the light-aging preventing agent in an amount of 0.001-10wt.%, preferably 0.01-1wt.% based on the total cosmetic. The hexahydrocurcumin can be produced e.g. by reducing curcumin with hydrogen. The cosmetic is preferably applied in the form of cream, milky lotion, oil, etc., from the viewpoint of percutaneous absorbability.
Conventional conditioning regimen with intravenous (i.v.) Busulphan (Busilvex), 12.8 mg/kg followed by Cyclophosphamide, 120 mg/kg iv.
Standard treatment - delayed intervention. Counselling on complementary feeding + Vitamin A (200,000 IU) every 6 months until 36 months + 1 kg maize / soy flour 2-weekly (71 g / day) between 18 and 30 months of age.
OBJECTIVES: This study aimed to evaluate the diagnostic accuracy of contrast-enhanced computed tomography (CT) in detecting bone invasion in oral squamous cell carcinoma (OSCC) patients and to explore clinicopathological factors associated with its reliability.
MATERIALS AND METHODS: 417 patients underwent preoperative contrast-enhanced CT followed by radical surgery. The presence or absence of bone invasion served as the outcome variable, with histopathologic examination of the resection specimen considered the gold standard. Statistical analyses, comprising correlation analyses and the determination of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were conducted.
RESULTS: CT exhibited 76.85% sensitivity, 82.20% specificity, 47.14% PPV, and 89.67% NPV. False-positive and false-negative rates were 11.27% and 5.99%, respectively. Artifacts affected assessment in 44 patients, but not in those with bone invasion. Tumor size, depth of invasion (DOI), tumor localization at the upper jaw, lymphatic invasion, and perineural invasion correlated with incorrect identification of bone invasion (Chi-square, p < 0.05).
CONCLUSIONS: Despite utilizing thin-section CT, notable false-positive and false-negative results persisted. Patients with T3 tumors, DOI ≥ 10 mm, or upper jaw tumors are at higher risk for misidentification of bone invasion. Combining multiple methods may enhance diagnostic accuracy, and the integration of artificial intelligence or tracking electrolyte disturbances by tumor depth profiling shows promise for further assessment of bone invasion before histopathology.
CLINICAL RELEVANCE: Surgeons should consider these insights when planning tumor resection. Supplementary imaging may be warranted in cases with high risk factors for misidentification. Further methodological advancements are crucial for enhancing diagnostic precision.
The invention discloses a bacillus amyloliquefaciens with an anti-helicobacter pylori effect and application thereof, and relates to the technical field of microorganisms. The strain is preserved in Guangdong province microorganism strain preservation center at 20 days 8 months 2022, the preservation address is microbial research institute of Guangdong province academy of sciences of No. 59 building of No. 5 building of No. 59 college of Mieheli Zhou, guangzhou city, the preservation number is GDMCCNo:62718. the bacillus amyloliquefaciens JY022 is obtained by separation, and metabolites and thalli of the bacillus amyloliquefaciens JY022 have strong inhibition capacity on helicobacter pylori. The lactobacillus paracasei JY062 has strong adhesion capacity and can prevent helicobacter pylori from being planted in vivo, and the metabolite and thallus of the lactobacillus paracasei JY062 and the bacillus amyloliquefaciens JY022 have strong inhibition capacity on the helicobacter pylori, so the lactobacillus paracasei JY062 and the bacillus amyloliquefaciens JY022 act together to prevent and remove the helicobacter pylori invading in vivo.
Mail-based Self-Help plus an Internet-based Intervention plus Telephone Counseling. Participants will receive a self-help manual, have access to an internet-based smoking treatment and participante in 6 telephone counseling sessions.
The invention provides a simvastatin dry powder inhalant. The simvastatin dry powder inhalant comprises a simvastatin liposome compound and pharmaceutically acceptable auxiliary materials. The simvastatin liposome compound is obtained by compounding cyclodextrin-coated simvastatin with phospholipid. The invention further provides a preparation method of the simvastatin dry powder inhalant. According to the simvastatin dry powder inhalant, the cyclodextrin-coated simvastatin and the phospholipid are compounded into the simvastatin liposome compound which is then compounded with the pharmaceutically acceptable auxiliary materials to obtain the dry powder inhalant; after pulmonary administration of the simvastatin dry powder inhalant, effective part deposition amount of simvastatin can be increased remarkably, so that the efficacy of pulmonary simvastatin administration on treatment of pulmonary diseases such as asthma and chronic pulmonary obstruction is improved. Experimental results show that, by the simvastatin dry powder inhalant, the effective part deposition amount is increased remarkably and curative effect on the pulmonary diseases is improved.
We continue our review of on punctal stenosis by providing a detailed discussion of management modalities, their complications, and outcomes. There is a significant change in the understanding of punctal and peripunctal anatomy, puncto-canalicular junction, and the lacrimal pump mechanisms. While the snip punctoplasty procedures are still practiced, there is an increasing trend toward nonincisional procedures. The nonincisional procedures in select cases appear to be equally effective as the incisional ones. Although simple to use, punctal plugs never became the mainstay of treatment because of design issues and the inability to address the coexisting canalicular stenosis. Placing stents only in the lower punctum in cases of upper and lower punctal stenosis should be discouraged, and management needs to address punctal stenosis and not which punctum is involved. Several types of stents are used in the management of punctal stenosis, mostly based on surgeon's preference. The benefits of adjuvant mitomycin C are uncertain. In view of literature on how stent biofilms can themselves cause chronic inflammation, placing them for prolonged periods should be reviewed and debated. Enhanced understanding of the molecular pathogenesis of punctal stenosis and addressing the current controversies in management would help standardize the therapeutic interventions available in the lacrimal armamentarium.
A system and method for monitoring and analyzing Internet traffic is provided that is efficient, completely automated, and fast enough to handle the busiest websites on the Internet, processing data many times faster than existing systems. The system and method of the present invention processes data by reading log files produced by web servers, or by interfacing with the web server in real time, processing the data as it occurs. The system and method of the present invention can be applied to one website or thousands of websites, whether they reside on one server or multiple servers. The multi-site and sub-reporting capabilities of the system and method of the present invention makes it applicable to servers containing thousands of websites and entire on-line communities. In one embodiment, the system and method of the present invention includes e-commerce analysis and reporting functionality, in which data from standard traffic logs is received and merged with data from e-commerce systems. The system and method of the present invention can produce reports showing detailed “return on investment” information, including identifying which banner ads, referrals, domains, etc. are producing specific dollars.