anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Many cutaneous lesions are clinically suspected as "cyst"; however, following histopathological examination, are found to be more significant lesions. Here, we examine the frequency and features of malignancies with cutaneous cysts in the clinical differential.
METHODS: A retrospective study of surgical pathology specimens at the James A. Haley Veterans' Hospital from January 2018 to December 2022 was conducted. Cutaneous specimens containing the clinical diagnosis of "cyst" were included. The clinicopathological features were summarized.
RESULTS: Premalignant or malignant neoplasms accounted for 4.5% of all specimens submitted with cysts in the clinical differential. Most cyst-mimicking cancers were basal cell carcinoma (BCC) or squamous cell carcinoma (SCC); however, cancers with poorer prognoses, such as Merkel cell carcinoma and melanoma, also clinically masqueraded as cysts. The BCCs were predominately nodular, and the SCCs were largely well-differentiated and invasive. Many exhibited clinical signs and symptoms compatible with benign cysts, such as central punctum, pain, and rapid growth. Identified risk factors included history of prior non-melanoma skin cancer diagnosis, previous excision, and immunosuppression.
CONCLUSIONS: Many lesions clinically concerning cutaneous cysts were found to be malignancies following histopathological review. Accordingly, following biopsy all cyst-like lesions should be examined microscopically, especially in certain clinical contexts in which the incidence of skin cancer is increased.
NEW MATERIAL:1-(4-Benzyloxyphenyl)-2-(4-benzylpiperidino)propan-1-ol of formula I . USE:Synthetic intermediate of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-propal-1-ol useful as a drug for circulatory organs. PREPARATION:The compound of formula I is prepared by reducing the ketone of formula III with a metal hydride preferably sodium borohydride. The reaction solvent is preferably a lower alcohol when sodium borohydride is used as the reducing agent. The reaction is carried out at -20-+100 deg.C, preferably 0-70 deg.C. The erythro-isomer of the compound of formula II useful as a drug for circulatory organs is known as ifenprodil which is a drug for mitigating the sequela of cerebral infarction, cerebral hemorrhage, etc., and the erythro-isomer is preferentially produced from the compound of formula I .
Neuroblastoma (NBL) accounts for 8-10% of all childhood malignancies. It is the most common solid tumor outside the central nervous system in people \<18 years of age. It occurs in 6-11 / 1 million children annually. In Poland, NBL is diagnosed annually in 60-70 patients, in 1/3 high-risk disease (HR). In 90% of children, NBL is diagnosed before the age of 5. The diagnosis is made on the basis of the histopathological assessment of the tumor tissue or the presence of NBL cells in the bone marrow together with elevated levels of catecholamines or their metabolites in the urine. The prognostic factors include the patient's age at diagnosis, stage of disease, tumor histopathology, DNA ploidy, MYCN gene status, chromosomal changes, and initial response to therapy. Due to the different course of the disease, the therapeutic decision is made after determining the risk group based on international criteria (International Neuroblastoma Risk Group Stage System, INRGSS and International Neuroblastoma Staging System, INSS). In the lowest-risk group, management is limited to observation or surgery, and in the intermediate-risk group, only standard low- and intermediate-intensity chemotherapy or combined with radiation therapy and surgery is performed. In contrast, HR-NBL uses intensive combination therapy, including standard induction chemotherapy, surgery, high-dose chemotherapy (HD-CHT) and autologous hematopoietic stem cell transplantation (auto-HSCT), radiotherapy and maintenance therapy with 13-cis retinoic acid and targeted immunotherapy with anti-GD2 antibodies. Treatment outcomes in NBL vary from spontaneous tumor regression in some infants to an OS rate of \<50% despite intensive combination therapy in the HR-NBL group.
BMI above 30 kg/m2 and being 18 to 60 years of age. Since the initiative is open for the general obese population, the investigators did not define the size of the cohort, but expect around 500 referrals per year.
The invention belongs to the technical field of traditional Chinese medicinal materials, and discloses a traditional Chinese medicine composition for treating rheumatism bone disease and traumatic injury, and a preparation method and a use method thereof. The composition is prepared by mixing garden balsam stem, safflower, peach seed, processed arisaema tuber, officinal magnolia bark, turmeric, cassia twig, fourstamen stephania root, Chinese angelica, pseudo-ginseng, twotooth achyranthes root, danshen root and liquoric root. The preparation is suitable for treating traumatic injury due to rheumatism, synovitis, knee arthromyodynia, etc. Has effects of eliminating dampness, promoting diuresis, relieving swelling and pain, relaxing muscles and tendons, and promoting blood circulation. The preparation method of the traditional Chinese medicine composition is simple and convenient, and in the process of reducing and treating the raw materials, the loss of effective components in the raw materials can be reduced, the content of the effective components is improved, and the using drug effect is further improved. The prescription is an external prescription, is prepared into a powder finished product, is favorable for storage, can be used by directly blending water in the subsequent actual use, has extremely high convenience and safety, and has no toxic or side effect and irritation.
Patient receive pulmonary tuberculosis standard treatment: isoniazid, rifampicin, pyrazinamide, and ethambutol in first and second month(weight adjusted dose), then in third to sixth month switch tuberculosis standard treatment to isoniazid and rifampicin(weight adjusted dose). In all 6 months, patient receive placebo drug 1 tablet simultaneously.
PURPOSE:To obtain an enteral nutriment composition, containing a diglyceride as a lipid ingredient and hardly loading enteric canals and causing any side effects. CONSTITUTION:An enteral nutriment composition containing a diglyceride, e.g. a compound expressed by the formula (two of R<1> to R<3> are acyl derived from a 12-22C saturated fatty acid or unsaturated fatty acid and the rest is H), preferably a compound having an acyl group derived from a 16-20C unsaturated fatty acid as an active ingredient. The aforementioned diglyceride is obtained by transesterification of, e.g. a mixture of fats and oils (e.g. rapeseed oil) with glycerol in the presence of an alkali (earth) metallic hydroxide or reacting a lipase with a mixture of a fatty acid or its ester with the glycerol and conducting esterifying reaction. The above-mentioned composition is capable of providing high energy to patients without loading enteric canals and causing any side effects even in including a large amount of the diglyceride.
The first acupressure application will be administered and taught individually by the researcher to the oncology patients in the self-administered group. Afterwards, each patient who learns the application will be asked to apply acupressure on his own for three days. In the self-acupressure group, a questionnaire form consisting of a personal information form, visual analog scale, nausea, vomiting and retching index and mental well-being scale will be applied first (pre-test) before the acupressure application is taught to the group by the researchers. Afterwards, patients will apply acupressure on their own for three days, and at the end of this period (post-test), a questionnaire consisting of personal information form, visual analog scale, nausea, vomiting and retching index and mental well-being scale will be applied. Acupressure will be applied the large intestine meridian 4th Point (LI4), the pericardium meridian Neiguan (P6) and Yintang (EX-HN3).
Nutritional supplement compositions that may provide sub-cellular phytonutrient delivery include a carrier oil base containing at least one triglyceride and also contain at least one biologically active complex in the carrier oil base. The biologically active complex may include a non-covalent complex of a carbon-60 fullerene, phytonutrient compound, and a triglyceride from the carrier oil base. The phytonutrient compound may be chosen from compounds having the ability to form non-covalent complexes with six-membered aromatic rings of carbon-60 fullerene. Examples of such phytonutrient compound include, for example, phenolic compounds, polyphenolic compounds, phenolic acids, flavonoids, terpenoids, tannins, stilbenes, curcuminoids, coumarins, lignans, quinones, phenylethanoids, carotenoids, astaxanthin, zeaxanthin, or coenzyme Q10. The nutritional supplement compositions may include multiple biologically active complexes in which the phytonutrient compounds are derived from olives, algae, or both. The nutritional supplement compositions may mitigate various diseases or disorders for which inflammation is an etiologic factor.
Participants in this group will receive the same standard assessment and individualized recommendations as the comparator group, but will also be counselled to restrict their eating to between 11 am and 7 pm during the program starting the evening of the consultation. They will also be advised to perform their home-based exercise sessions during the fasting period in the morning.
<P>PROBLEM TO BE SOLVED: To achieve the mass production of double-layer suppository comprising outer and inner layers with a higher precision.  <P>SOLUTION: The first rotary valve 11 for supplying the first base medicine, the second rotary valve 21 for supplying the second base medicine and a double nozzle 30 in which the tip of an outer nozzle 31 is positioned below the tip of an inner nozzle 32 are used to supply the first base medicine from the outer nozzle 31 while the second base medicine is supplied from the inner nozzle 32. At this point, the first and second rotary valves 11 and 21 are sucked back and then, the subsequent base medicine is supplied. Each of the rotors 60 of the rotary valves 11 and 21 has at least one or more stick-like packings 77 on the circumferential surface of the rotor 60 in the direction of the rotating shaft of the rotor 60 and an O ring 78 is provided on the outer circumference of the rotor 60 being kept in contact with the tips of the stick-like packings 77. Moreover, an O ring 79 is provided on the circumference of a cylinder communication hole 66 on the end face of the rotor 60.  <P>COPYRIGHT: (C)2003,JPO
Premature infants frequently suffer from feeding intolerance related to prematurity and are highly associated with morbidity and mortality. \[1\] Feeding intolerance (FI) is defined as difficulty to digest enteral feedings and is accompanied by an increase in gastric residuals, abdominal distension, and/or reflux. It is common in preterm infants and commonly results in feeding and gastrointestinal disruptions. FI in newborns can be a sign of a variety of problems, ranging from minor, self-limiting illnesses to serious, life-threatening illnesses. \[2\] The common cause of FI is low intestinal motility because of prematurity , Enzymatic digestion, bacterial colonization, hormonal response, and local immunity are also possible reasons for FI. \[3\] FI is very common among preterm infants and its clinical symptoms include abdominal distension, vomiting, bilious gastric residuals, occult or gross bloody stools, and are observed in nearly 29% of such neonates. \[4\] Factors that contribute to feeding intolerance include poor coordination of sucking and swallowing, incompetent lower esophageal sphincter, small gastric capacity, delayed gastric emptying time, and intestinal hypomotility. Abnormal bacterial colonization may be a coexisting factor in feeding intolerance in newborns mainly due to dysfunction of the intestinal barrier, the immune responses, and sensory motor functions of the gut. \[5\] Mother's milk feeding is related to better feeding tolerance and may be correlated to a reduction in severe morbidity. \[6\] The mode of delivery (vaginal or cesarean section) and feeding type (breastfeeding or formula feeding) of neonates are considered the most influential factors in the development of gut microbiota. \[7\] In the preterm infant, the readiness to tolerate enteral nutrition relies upon the degree of maturation of gastro-intestinal (G-I) functions (motility, enzymatic digestion, hormonal responses, bacterial colonization and local immunity). Anatomical development of the GI tract is largely completed at 20 weeks of gestation, although the elongation of the GI tube and increases in the absorbing area (microvilli) continue during the last trimester of gestation and beyond. \[8\] Successful establishment of enteral feedings is a major goal in the treatment of very low-birthweight infants, but functional immaturity of the gastrointestinal tract may hamper such efforts. Prokinetic agents often are used in an attempt to overcome functional immaturity by speeding up gastric empyting and increase intestinal wall motility.\[9\]
Participants who meet the inclusion criteria after cesarean section and are assigned to the caffeinated coffee group by randomization method will be informed about the research and their verbal and written consent will be obtained. Immediately before coffee application (6-12-18 hours after surgery), women's pain intensity and bowel motility will be evaluated. Women will then be asked to consume 100 ml of unsweetened caffeinated coffee at 6, 12 and 18 hours after surgery. 6,12,18. Half an hour after coffee consumption, women will be evaluated for pain using VAS. At the same time, the women's bowel sounds, gas passing and defecation will be recorded during these hours.
5- Sunkatol No. 1 replaces medical usage of the N- phenethyl-acetamide in Killing Mycobacterium Tuberculosis infection, is related to pharmaceutical field.5- Sunkatol No. 1 replaces pharmaceutically acceptable salt of the N- phenethyl-acetamide with pharmaceutically acceptable salt or its pro-drug or its pro-drug；Medical usage in Killing Mycobacterium Tuberculosis infection has good prospect.5- Sunkatol No. 1 replaces N- phenethyl-acetamide to act on mycobacterium tuberculosis wild type RpsA and saltant type RpsA simultaneously, and action intensity is higher, show that 5- Sunkatol No. 1 replaces N- phenethyl-acetamide that can efficiently solve mycobacterium tuberculosis since RpsA is mutated bring resistance problems, also shows 5- Sunkatol No. 1 simultaneously and replace N- phenethyl-acetamide that can specifically act on wild type RpsA and saltant type RpsA.
The invention discloses a vaccaria segetalis extract for inhibiting angiogenesis, preparation and application, belonging to the field of traditional Chinese medicine applying technique. The invention provides a process for preparing vaccaria segetalis extract. Dry seeds of vaccaria segetalis are extracted through water or organic solvent or organic solvent with water and the extracting liquid is filtered, concentrated and dried. The invention discovers for the first time that the vaccaria segetalis extract has the activity of inhibiting angoiogenesis and can be used for curing and preventing diseases relating to angiogenesis, and furthermore can be used for tumour chemotherapy and/or auxiliary treatment of chemotherapy. The invention skillfully takes angiogenesis as the target for curing diseases, studies and expounds the medicinal efficacy and mechanism of vaccaria segetalis extract, and provides scientific proof and significant information for developing new usages of vaccaria segetalis extract and finding new targets of medicament function, which is a new developing orientation of traditional Chinese medicine theory. The vaccaria segetalis extract can be used as medicaments, health care products, and /or cosmetics and the like.
Radiosurgery can be performed using multiple Co-60 sources, a modified traditional gantry-based linear accelerator, or a robotic linear accelerator. Each technique has its own advantages and disadvantages. Co-60 radiosurgery has very precise target localization by using a rigid immobilization device. The requirement for rigid immobilization limits its treatments to the head and neck. Robotic radiosurgery permits precise radiation to be delivered without the requirement for rigid immobilization. Robotic radiosurgery uses real-time imagining, allowing it to track the cancer or internal structures as they move during treatment. Another advantage is that it can deliver many small beams of radiation (as many as 200) in a limited time period and can treat lesions anywhere in the body. A traditional gantry-based linear accelerator normally requires some form of immobilization and requires more time for multiple isocentre set up but can provide both radiosurgery and conventional treatments.

Brain metastases occur in up to 50% of patients with cancer. It has been reported up to 65% of patients with brain metastases will present with one to three lesions. This represents 18,000 patients in Ontario each year who would be eligible for radiosurgery as part of their management. Randomized trials have demonstrated improved palliation and overall survival when radiosurgery is added to conventional whole brain radiation therapy (WBRT). As a result the treatment of brain metastases currently represents the largest resource use for radiosurgery. During the commissioning and initial use of the first robotic radiosurgery device in Ontario (CyberKnife) the investigators became aware of its potential advantages for the treatment of brain metastases. Treatment planning time and on treatment time with robotic radiosurgery appeared to be better than with a traditional linear accelerator and patients appeared to be more comfortable with the minimal/ non-invasive immobilization required. Surprisingly, there were very little direct comparisons of robotic radiosurgery with other techniques in the literature and only one prospective randomized trial comparing two different approaches to delivering Co-60 radiosurgery was identified. Given the increasing importance of radiosurgery and the resource implications for radiation treatment programs in Ontario, this study is proposed to conduct a direct comparison of robotic to traditional linear accelerator radiosurgery for brain metastases. The primary outcome will be treatment planning and delivery time and an important secondary outcome is patient comfort. Treatment planning time will include immobilization preparation, CT simulation, image fusion, radiation planning and treatment plan quality assurance. Treatment delivery time will include patient set up, target localization and treatment delivery. The Juravinski Cancer Centre (JCC) and McMaster University are uniquely posed to perform this comparison with access to both robotic and linear accelerator radiosurgery techniques as well as research methodology expertise in clinical trials technology assessment, and health services research.
Cerebral ischemic stroke is a major contributor to physical impairments and premature death worldwide. The available reperfusion therapies for stroke in the form of mechanical thrombectomy and intravenous thrombolysis increase the risk of cerebral ischemia-reperfusion (I-R) injury due to sudden restoration of blood supply to the ischemic region. The injury is manifested by hemorrhagic transformation, worsening of neurological impairments, cerebral edema, and progression to infarction in surviving patients. A complex network of multiple pathological processes has been known to be involved in the pathogenesis of I-R injury. Primarily, 3 major contributors namely oxidative stress, neuroinflammation, and mitochondrial failure have been well studied in I-R injury. A transcription factor, Nrf2 (Nuclear factor erythroid 2-related factor 2) plays a crucial defensive role in resisting the deleterious effects of I-R injury and potentiating the cellular protective mechanisms. In this review, we delve into the critical function of mitochondria and Nrf2 in the context of cerebral I-R injury. We summarized how oxidative stress, neuroinflammation, and mitochondrial anomaly contribute to the pathophysiology of I-R injury and further elaborated the role of Nrf2 as a pivotal guardian of cellular integrity. The review further highlighted Nrf2 as a putative therapeutic target for mitochondrial dysfunction in cerebral I-R injury management.
Participants will receive escitalopram on days 1-21 for this treatment period. Oxycodone will be administered on days 6, 12, and 21 of this treatment period.
Exercise group includes exercises without electric stimulation. Exercise group will have 45 minutes of exercises which are specific exercises for Lumbar Disc Herniation.
The rise of operational noise as an environmental pollutant for farm animals is an emerging concern. The mechanisms through which music can alleviate oxidative stress, inflammation, and apoptosis induced by noise exposure remain underexplored. This study aims to investigate the alleviating effects and underlying mechanisms of long-term music exposure on noise-induced damage to the chicken spleen. Male Arbor Acres (AA) broilers were divided into four groups: control (C), acute noise stimulation (NS), noise stimulation with music mitigation (NSM), and music only (M). NS and NSM groups were exposed to noise (simulating sudden intensity noise, 115 to 120dB) for 10 minutes daily for a week, starting at 14-days-old. NSM and M groups then received 28 days of 6-hour daily music (Mozart K.448, 60-65 dB). The results showed that noise stimulation significantly activated the Keap-1/Nrf2 and NF-κB signaling pathways. Long-term music intervention has also been demonstrated to successfully mitigate oxidative stress and abnormal apoptosis induced by acute noise stimulation. Microscopic examination of the spleen revealed that acute noise stimulation resulted in an increase in splenic cells, a decrease in lymphocytes, and blurred boundaries between the red and white pulps in the NS group. However, these pathological changes were alleviated in the NSM group following music intervention. Compared with the control group, the NS group exhibited significantly elevated oxidative stress parameters. In contrast, music intervention in the NSM group notably improved antioxidant capacity and partially alleviated morphological abnormalities in the spleen. Additionally, noise stimulation activated the NF-κB pathway, upregulating the downstream genes of the inflammatory factors IL-1β, IL-6, and TNF-α. Noise-induced mitochondrial damage led to apoptosis, as observed by TUNEL staining, along with increased gene and protein expression of Bcl-2, Bax, Cyt-C, Casp-3, Casp-8, and Casp-9. These findings indicate that acute noise exposure can induce splenic damage via oxidative stress, inflammation, and apoptosis by modulating the Keap-1/Nrf2 and NF-κB pathways. Prolonged music stimulation effectively mitigates noise-induced damage, offering a vital experimental foundation for further research on noise pollution's impact on organisms and music's alleviating role.
The first control group will apply the dexamethasone oral rinse 0.5 mg/5ml treatment. The oral rinse is considered a topical rinse because it is confined to the oral cavity (topical) and not swallowed. Subjects will be reminded by the study team via a phone call a few days before their visit that they must not drink water or eat at least 60 min before their visit. Once we get to the stage of the rinse, we will first their oral cavity with gauze. Then, we will instruct the subject to Rinse their mouth with 0.5mg/5ml dexamethasone for 5 min, then spit into a provided plastic cup the oral rinse. This will then be discarded down the drain.
Intervention: administration of ultrasound contrast agent (drug) to assess muscle perfusion. Normal healthy subjects (n=10) will be used for optimization of dose and acoustic settings for performing real-time contrast ultrasound perfusion imaging of the limb.