anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Rapid, integrated information exchange between stakeholders is critical for effective emergency preparedness and response. However, many low- and middle-income countries face barriers to seamless data sharing. While information accessibility is recognized as important for evidence-based decision-making and resource allocation in Ethiopia, factors influencing current health information sharing practices among stakeholders involved in public health emergency management programs are unclear. This study aims to examine multi-sectoral stakeholders' perspectives and experiences with health data sharing during emergencies in Ethiopia, to identify opportunities and challenges influencing practices to strengthen the national public health emergency response system.
METHODS: A mixed-methods study was conducted between June and August 2023, involving a survey of 169 stakeholders actively involved in PHEM programs in Ethiopia as well as 23 in-depth interviews with key informants in senior leadership or advisory roles. The data was analyzed using descriptive statistics in SPSS and thematic analysis of qualitative transcripts.
RESULTS: During emergencies, it was observed that data sharing between different entities occurred. Quantitative findings showed the predominant types of health data shared between stakeholders during emergencies included hospital data (109, 64.5 %), clinical case information, and laboratory results. Challenges limiting effective coordination included issues like limited functionality of digital health systems (75, 44 %), incompatible data formats (13, 34 %), and financial constraints (83, 49 %) and and socio-cultural barriers constrain current practices in Ethiopia. Qualitative interviews identified five themes around risk communication and inclusive alert systems. Experts emphasized tailored, multichannel outreach but noted infrastructure gaps and digital divides currently limit poorer communities' engagement.
CONCLUSION: While collaborative health information exchange during emergencies is recognized as important, systemic, financial, and socio-cultural barriers constrain current practices in Ethiopia. Targeted strategies including capacity building, investment in integrated data infrastructure, economic optimization through innovative financing models, trust-based relationship development, and locally relevant communication channels informed by stakeholder perspectives can optimize information accessibility, coordination, quality, and equity of healthcare services during public health emergencies.
Patients with neovascular glaucoma undergoing shunt implant surgery with MMC during and 5FU after surgery .This method will use Ahmad FP7 model valved shunt (New World Medical, LA), which is one of the most commonly used shunts in the world. First, 5FU at a dose of 0.04% is placed in the shunt plate for two minutes and then rinsed. The shunt is fixed and then the shunt tube is inserted into the eye and fixed with nylon 10.0 thread. The conjunctiva is also swabbed with 8.0 vicryl sutures. After the operation, patients undergo regular examinations according to a specific protocol to evaluate the effectiveness as well as possible complications. Also in the first, third and fifth weeks, 5FU injections are given as a subconjugate with a volume of 0.1 ml containing 5 mg of the drug.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to the preparation of nimesulide as gel for topical use for treatment of patients with skin inflammations. The preparation has 0.5-7 wt.-% of nimesulide, gel-forming agent, solvent, preserving agents and, if necessary, stabilizing agent and mixture of caprylic and capric acids esters with glycerol. Gel-forming agent is taken among 0.1-5 wt.-% of carboxyvinyl polymer neutralized with triethanolamine or diisopropanolamine an aqueous solution or 0.5-10 wt. -% of polyacrylamideisoparaffin. Solvent is taken among the group including ethanol, isopropanol and diethylene glycol monoethyl ester. The concentration of ethanol and isopropanol in preparation is from 5 to 20 wt.-%, diethylene glycol monoethyl ester is from 40 to 95 wt.-%. Method of preparing the preparation involves preparing an aqueous dispersed phase containing water-soluble preserving agents and carboxyvinyl polymer, addition of alcohol solvent, dispersing nimesulide, water-insoluble preserving agents and, if necessary, additions (moistening agents and enhancers of dermal sorption), neutralization of carboxyvinyl polymer with triethanolamine or diisopropanolamine an aqueous solution. The second variant of method involves preparing an aqueous phase, preparing organic phase, dispersing organic phase in aqueous phase and neutralization of carboxyvinyl polymer by addition of triethanolamine or diisopropanolamine. An aqueous phase has water-soluble preserving agents, mixture of caprylic and capric acids esters with glycerol and homogenously dispersed carboxyvinyl polymer. Organic phase has water-insoluble preserving agents, preferably a mixture of parabens, and nimesulide in diethylene glycol monoethyl ester. Use of nonwater solvents in preparing the gel system of nimesulide provides improvement of physical-chemical indices of preparation and indices of release and absorption of nimesulide based on its ability to dissolve dermal lipid barrier. EFFECT: improved method of preparing. 7 cl, 5 ex _
Exercise therapy is the first choice of treatment in the management of subacromial shoulder pain (SSP). Guidelines suggest active rehabilitation program for at least three months and existing research highlights the importance of progressive loaded exercise therapy at higher dosage. However, it is not clear which is the best type of exercise and if pain should be provoked during exercise. Recent research found that painful exercises are beneficial in short term on pain and function in patients with different kinds of chronic musculoskeletal pain. The aim of the future randomized clinical trial is to investigate if "exercising into pain" gives better results in term of clinical outcomes compared to a non-painful exercise program. Since the intervention consists in painful exercises, it is essential to test the rate of adherence in the intervention group (both during physiotherapist-led session and home-based exercises). Moreover, the practicability of clinical questionnaire via online survey will be tested and the time needed to collect clinical data will be calculated as well. Furthermore, feedback from physiotherapists and participants will be collected and analyzed.
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such ribonuclease is referred to herein as a dsRNase, wherein "ds" indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.
The permanent bedding of critically ill neonates and infants in the pediatric intensive care unit (PICU) for an extended amount of time can result in the development of pressure injuries (PI). This results in a further prolongation of the hospital stay, additional suffering of the patient, scarring, increased mortality and morbidity, and increased healthcare costs. Infants are at particular risk since their skin hasn't matured yet and is mechanically weak, and for example neonates lack a robust stratum corneum entirely. Furthermore, the thickness of their skin is reduced by 60% when compared to skin of adults. Thus, pressure cannot be equally absorbed leading to higher tissue internal stress. PIs can form due to high and permanent local interface pressure induced by contact with bed surfaces or other medical devices. Contact pressure can hamper blood flow in subcutaneous areas, increasing susceptibility for pressure injuries. While sophisticated equipment to manage the interface pressure and reduce the risk of developing pressure injuries is abundant for adults, very little is designed explicitly for neonates and infants. The currently available air mattresses are not being used due to safety concerns and impracticability. Furthermore, they are designed for infants from half a year of age and, thus, not considering the low body weight of premature babies or neonates. This is why the currently used conventional foam mattresses remain first choice. However, foam mattresses are designed for optimal support of a specific weight and, therefore, making them unsuitable for the use as a one-fits-all solution in a highly heterogenic patient cohort. In addition, compressed foam gets stiffer at compressed areas, increasing the local pressure impact and, thus, PI risk. On the other hand, the structures of the hereby-developed air mattress can freely move and optimally adjust to the patient's body shape. This increases contact area, reduces the average interface pressure and blunts local pressure peaks at the areas with the most indentation, ensuring a more homogenous pressure distribution at a lower level. This ultimately is expected to result in a lower PI incidence. As a side effect, lying comfort for the patient will be increased.
We are conducting a randomized trial of two online, provider-facing education modules regarding lung cancer screening and smoking cessation. We will accrue 70 MedStar primary care providers (PCP). The baseline survey will incorporate items regarding lung cancer screening knowledge, providers' attitudes towards lung cancer screening, lung cancer screening ordering practices and provider characteristics. At the end of the baseline survey, PCPs will be randomly assigned to the LuCa + Health Disparities or LuCa only. PCPs will be asked to complete the intervention and the post-test within 1 week of randomization. The post test will cover knowledge of lung cancer screening, attitudes and opinions toward LCS. To assess PCP lung cancer screening ordering practices, we will review the MedConnect Electronic Health Record (EHR) to compare the two study groups post-randomization on the number of orders made for LCS.
The invention is concerned with compound Bi yan kang spray agent. Each 10 bottles relate to 0.8 g bear bile powder, 3.5 g fructus xanthii, 4.5 g scutellaria baicalensis, 1 ml flos magnoliae oil, 2 g herba houttuyniae, 0.1 g menthol and 0.1 g borneol. Decoct fructus xanthii, scutellaria baicalensis and herba houttuyniae with water for three times and each time is 1.5 hours. Unite the decocted liquid to filtrate to concentrate to suitable thick cream (opposite density, under 50 degree). Add water till to 1000 ml and add bear bile powder to boil till dissolving, filtrate. Cool the filtrate, dissolve borneol, menthol and sorbic acid in 35 ml ethanol and mix with Tween-80 to add into the said filtrate, stir and add wate till 1200 ml, stir, stay for 24 hours, filtrate, add 10 ml flos magnoliae oil, divide and pack to get the procuction. Each bottle has 15 ml in brown bottle. This mrthod uses bear bile powder, fructus xanthii and scutellaria baicalensis to get rid of bacterium to adjust the circumstance of nasal cavity and repair nasal cavity to enhance the immunity abilityof nasal cavity and it has good effect to all kinds of rhinitis.
Chronic liver diseases (CLD) impact over 800 million people globally, causing about 2 million deaths annually. Arbidol (ARB), an indole-derivative used to treat influenza virus infection, was extensively used during COVID-19 pandemic in China. In recent years, studies have shown that ARB, compared to other antiviral drugs, exhibits greater liver-protective efficacy, indicating a potential hepatoprotective effect beyond its antiviral activity. However, the mechanism remains unclear. In this study, we investigated the impact of ARB on liver injury/fibrosis in bile duct ligated (BDL) mice and its effect on spontaneous and transforming growth factor β1 (TGF-β1)-induced activation of primary cultured hepatic stellate cells (HSCs). Oral administration of ARB significantly ameliorated BDL-induced liver injury/fibrosis as reflected by decreased serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), reduced collagen deposition, and diminished mRNA expression of fibrosis markers. ARB notably inhibited spontaneous and TGF-β1-induced activation of primary cultured HSCs. Moreover, ARB also drastically attenuated mRNA expression levels of platelet-derived growth factor receptor (Pdgfr), transforming growth factor-beta receptor (Tgfbr) 1, Tgfbr2, matrix metalloproteinase (Mmp)-2, and Mmp-9 in activated HSCs. We further demonstrate that ARB mitigated Smad2/3 phosphorylation in both TGF-β1 treated HSCs and BDL mice. These data together demonstrate that the therapeutic efficacy of ARB on liver fibrosis is independent of its antiviral activity and likely is achieved by blocking TGF-β1 signaling-mediated HSC activation.
The systemic absorption of calcipotriene in subjects with psoriasis of the body was evaluated at steady state following application of either calcipotriene foam or calcipotriene ointment to a body surface area of 5% to 10%. In the calcipotriene foam treatment group, 15 out of 16 subjects had calcipotriene plasma concentrations below the limit of quantitation (10 pg/mL), while in the calcipotriene ointment treated group, 5 out of 16 subjects had measurable calcipotriene plasma concentrations at various time points. All measurable plasma calcipotriene concentrations were below 25 pg/mL.

The pharmacokinetics of calcipotriene foam, 0.005% was investigated when applied topically for 15 days to 17 subjects aged 12 to less than 17 years with moderate plaque psoriasis involving a mean BSA of 24%, excluding face and scalp, and a mean scalp involvement of 43%. Systemic concentration of calcipotriene were not quantifiable in any of the subjects (limit of quantification = 10 pg/mL).

In 11 pediatric subjects 7 to 11 years of age with plaque psoriasis involving a mean BSA of 10%, plasma concentration of calcipotriene was measured following 2 weeks of twice daily administration of calcipotriene foam. No subject had quantifiable calcipotriene plasma concentration (limit of quantification = 10 pg/mL).

The systemic disposition of calcipotriene is expected to be similar to that of the naturally occurring vitamin D. Absorbed calcipotriene is known to be converted to inactive metabolites within 24 hours of application and the metabolism occurs via a similar pathway to the natural hormone.
Cerebro/cardiovascular (CV) death accounts for approximately 30% of total deaths in Japan and therefore it is important to establish a preventive treatment for CV events from the point of public health. The guidelines proposed by a joint study group centering on the Japanese Circulation Society, recommend administration of aspirin to patients with multiple risk factors for primary prevention of arteriosclerotic diseases. In addition, the 2002 AHA guidelines recommend use of aspirin in patients with a 10% or higher 10-year risk of CV events. However, these descriptions are founded on randomized, comparative study results and epidemiological data obtained outside Japan, while no epidemiological data are available in Japan that would allow prediction and selection of patients who could benefit from primary prevention with aspirin. Although the benefit of aspirin for secondary prevention has been proven in Japanese patients, the benefits of primary prevention are still controversial.

JPPP is a multicenter, open-label, centrally randomized, controlled trial. In total, 10,000 elderly patients with one or more CV risk factors (age 60-85 years combined with hypertension, hyperlipidemia, and/or diabetes) will be assigned to enteric-coated aspirin (100mg/day) or control. The primary endpoint is composite event of CV death, nonfatal stroke (of any cause) and nonfatal myocardial infarction.
The invention provides a swine streptococcicosis vaccine, and relates to the field of veterinary vaccines. The streptococcus suis vaccine has antigen protein with amino acid sequence as shown in SEQ ID No. 2. The invention also provides a preparation method of the streptococcus suis vaccine, which comprises the following steps: mixing white oil and aluminum stearate to obtain a white oil adjuvant; adding Tween-80 into the protein water solution with amino acid sequence shown as SEQ ID NO. 2, and mixing to obtain antigen solution; mixing the antigen solution with a white oil adjuvant according to a volume ratio of 0.5-1.5:2, and emulsifying to obtain the vaccine. The animal immunized by the streptococcus suis vaccine can effectively resist streptococcus suis type 2, 3 and 31 virus attack, the protection rate of the vaccine reaches 100 percent, the streptococcus suis vaccine is high in universality, the production cost and the inoculation workload are remarkably reduced, and the stress of the immunized animal can be reduced.
Low back pain is a common chronic disease that can severely affect the patient's work and daily life. The breakdown of spinal mechanical homeostasis caused by intervertebral disc (IVD) degeneration is a leading cause of low back pain. Annulus fibrosus (AF), as the outer layer structure of the IVD, is often the first affected part. AF injury caused by consistent stress overload will further accelerate IVD degeneration. Therefore, regulating AF injury repair and remodeling should be the primary goal of the IVD repair strategy. Mechanical stimulation has been shown to promote AF regeneration and repair, but most studies only focus on the effect of single stress on AF, and lack realistic models and methods that can mimic the actual mechanical environment of AF. In this article, we review the effects of different types of stress stimulation on AF injury repair and remodeling, suggest possible beneficial load combinations, and explore the underlying molecular mechanisms. It will provide the theoretical basis for designing better tissue engineering therapy using mechanical factors to regulate AF injury repair and remodeling in the future.
Clinical practice guidelines (CPG) allow optimizing medical decisions and health care based on the best evidence available. Nevertheless, CPGs have several limitations. First, many GPC are outdated shortly after their publication. Second, CPG recommendations are often not applicable to many patients treated in clinical practice. Most CPGs do not make recommendations for complex patients with comorbidities. Another limitation is that patients involvement in CPGs development is still poor. To overcome these limitations, study investigators developed TDApp, an eHealth tool to formulate decentralized, participatory, individualized and automated pharmacologic treatment recommendations for patients with Attention Deficit Hyperactivity Disorder. TDApp was initially tested in a clinical sample of ADHD patients (https://clinicaltrials.gov/ct2/show/NCT04228094), but, as it was the first human use, treatment recommendations were kept hidden to the clinicians until the last patient enrolled completed study participation. This safeguard was implemented to avoid potential misguidance. After completing this study, the investigators developed a new iteration of TDApp (TDApp2) that can also recommend non-pharmacological interventions.

In this study, the investigators aim to assess TDApp2: an eHealth tool that formulates participatory, participatory, explainatory and automated therapeutic recommendations for patients with Attention Deficit Hyperactivity Disorder. The recommendations made by TDApp2 will be compared with those made by relevant clinical practice guidelines in children/adolescents with ADHD.

A 6-week, one group, open label study will be conducted. Tirty-two children/adolescents aged \< 18 yo with ADHD and their parents will use TDApp. The treatment recommendations made by the TDApp2 will be compared to those made by relevant CPG (American Academy of Pediatrics CPG, Canadian ADHD Resource Alliance (CADDRA) GPC, National Institute for Health and Care Excellence (NICE) GPC, the Australian ADHD Professionals Association guideline, and the Spanish GPC). As the study will be carried out in Catalonia (Spain), the primary comparison will be performed vs. the Spanish CPG. Also, TDApp2 recommendations will be compared with the actual treatment prescribed by the clinicians.
New dye composition (I) for keratinous fibres, particularly human hair, comprises: at least one oxidising dye precursor (II); where appropriate, one or more couplers (III); and an amphiphilic anionic polymer (IV) comprising at least one hydrophilic moiety (V) and at least one fatty chain allyl ether moiety (VI). Also claimed is a method (VII) of dyeing keratinous fibres, particularly human hair, comprising the simultaneous or sequential application of (I) and an oxidising agent. Also claimed is a method (VIII) of dyeing keratinous fibres, particularly human hair, comprising the simultaneous or sequential application of a composition formulated as (I), with the possible omission of (IV), and a composition containing an oxidising agent and (IV). Also claimed are kits (IX) for the application of (VII) and (VIII). (I) and (IX) are used to dye human hair (claimed). (I) does not run, giving a deeper and brighter colour than dyes prepared according to prior art.An oxidation dye composition for keratin fibers, in particular for human keratin fibers such as the hair, comprising, in a medium which is suitable for dyeing, at least one oxidation dye precursor and optionally one or more couplers, and also an anionic amphiphilic polymer containing at least one hydrophilic unit, and at least one allyl ether unit containing a fatty chain. The oxidation dye compositions are used in dyeing processes and dyeing kits.
The invention relates to a traditional Chinese medicine preparation for treating alcoholic jaundice. The traditional Chinese medicine preparation comprises fructus gardeniae, rhubarb, fructus aurantii immaturus, fermented soybean, rhizoma zingiberis, medicated leaven, fructus trichosanthis, curcama kwangsinesis, raw radix glycyrrhizae, radix bupleuri, poria cocos, rhizoma atractylodis macrocephalae, salviae miltiorrhizae, polygonum cuspidatum, rhizoma cyperi, radix polygoni multiflori and herba artemisiae scopariae. The evident distinction between the alcoholic jaundice and common jaundice is that a patient with the alcoholic jaundice tends to vomit, so that an external dispersing method cannot be used in the treatment of the alcoholic jaundice, and an internal purging and discharge method is used. The traditional Chinese medicine preparation has the effects of soothing the liver and regulating the spleen, clearing away heat and toxic materials, relieving restlessness and moisturizing bowels and purging upper heat and warming middle-jiao. When the patient takes the traditional Chinese medicine preparation, the traditional Chinese medicine preparation acts on the whole body of the patient to fast improve symptoms such as spleen qi weakness, liver qi discomfort and upper-jiao stagnant heat, thoroughly relieve body and eye jaundice, oppression in the chest, thirst, eating incapability, frequent vomit tendency, reddish and astringent urine and deep wiry pulse. The pathogenic factors of the alcoholic jaundice is solved fundamentally, and the alcoholic jaundice can be treated radically.