anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Flow is an intrinsically rewarding state characterised by positive affect and total task absorption. Because cognitive and physical performance are optimal in flow, chemical means to facilitate this state are appealing. Caffeine, a non-selective adenosine receptor antagonist, has been emphasized as a potential flow-inducer. Thus, we review the psychological and biological effects of caffeine that, conceptually, enhance flow. Caffeine may facilitate flow through various effects, including: i) upregulation of dopamine D1/D2 receptor affinity in reward-associated brain areas, leading to greater energetic arousal and 'wanting'; ii) protection of dopaminergic neurons; iii) increases in norepinephrine release and alertness, which offset sleep-deprivation and hypoarousal; iv) heightening of parasympathetic high frequency heart rate variability, resulting in improved cortical stress appraisal, v) modification of striatal endocannabinoid-CB1 receptor-signalling, leading to enhanced stress tolerance; and vi) changes in brain network activity in favour of executive function and flow. We also discuss the application of caffeine to treat attention deficit hyperactivity disorder and caveats. We hope to inspire studies assessing the use of caffeine to induce flow.
The invention provides a sulfolobus solfataricus sulfated polysaccharide and a preparation method and application thereof, and relates to the technical field of polysaccharides. A method for preparing sulfated polysaccharide from Ascophyllum nodosum comprises removing impurities from Ascophyllum nodosum with alcohol or aqueous solution of alcohol, extracting with water, precipitating with ethanol, and dialyzing to obtain crude polysaccharide product. Purifying by anion exchange column to obtain high molecular weight polysaccharide component, and purifying by gel column to obtain sulforaphen. The preparation method has the advantages of high utilization rate of raw materials, mild process and high purity, and fully ensures the stability of the active structure of the sulfated polysaccharide. And toxic and harmful reagents such as acid and alkali are not used in the preparation process, so that the method is suitable for large-scale production. In addition, the invention also relates to the sulfoesterified polysaccharide of the ascophyllum nodosum prepared by the preparation method and the application thereof. The sulfated polysaccharide has high molecular weight and high sulfate group content, can adjust the level of intestinal flora, is applied to preparing products for adjusting intestinal functions, and has great development and application prospects.
An improved hair color formulation treats hair to provide volume, viscosity, color and hair follicle stimulation. The color formulation is appointed to be used in hair products, and comprises a natural color agent and at least one agent providing anti-dihydrotestosterone (DHT) effects. Hair products include styling products, cleansing products, concealment products, and dying products. In one embodiment, the formulation comprises an aqueous emulsion, at least one hydrocarbon, at least one thickening agent, at least one humectant, at least one emollient, at least one fatty acid ester, and at least one agent providing anti-dihydrotestosterone (DHT) effects, such as caffeine, and at least one color agent. Preservatives, fibers and further treatments for male/female pattern baldness may also be added to the composition. Natural colorants are added to the hair color formulation to provide temporary coloring in addition to enhanced volume, viscosity and hair follicle stimulation.
Participants randomized to this arm will receive a chronic disease self-management program including a self-management book. Participants will receive regular calls weekly during months 1-4, biweekly during months 5-6, and monthly during months 7-12.
PURPOSE:To provide a safe cosmetic containing anacardic acid obtained from a cashew nut shell oil, etc., high in a beautifully whitening effect, inhibiting the activity of hyaluronidase, effective for taking care of skin roughness, etc., and large in effects to maintain the gloss and tension of skin. CONSTITUTION:A cosmetic containing the derivative of anacardic acid. Especially a compound of formula I [A is COOH, COOCH3, CHO; B is CH3O, OH; R is group of formula II, formula III or formula IV (CmHn, CPHq are saturated or unsaturated hydrocarbon)], more especially the compound wherein the carbon atom number of R is 15, is preferable as the anacardic acid derivative. The anacardic acid derivative is obtained e.g. from an anacardic acid monoene, i.e., 6-[8(Z)-pentadecamonoenyl]salicylic acid [the 8(Z) exhibits the position of the enyl group] as a starting raw material, the compound being contained in a cashew nut oil having been low in utilization value. The anacardic acid derivative has a beautifully whitening action, a hyaluronibase activity-inhibiting action and further an active oxygen-reducing action. The cosmetic is high in the concentration of the active ingredient, little in adverse effects, and safe.
After stroke, diaphragm, the most important muscle of respiration, is wasted as well as the other muscles of the affected side.

Ultrasonography is a non-invasive, practical, low cost utility that may measure the thickness of diaphragm in maximum expiration and inspiration thus examining the functionality of the muscle. Correlation between respiratory functional tests and diaphragm ultrasonography has been proven in recent literature. In this manner, the aim of this study is twofold. First is to determine whether ultrasonography can be used practically to evaluate the respiratory functions of the patients after stroke. Respiratory function tests will be used for the correlation analysis. Second is to evaluate the effectiveness of respiratory exercises via diaphragm ultrasonography and respiratory function tests.
Healthy participants (family or friends) will have a neurologic exam to confirm non-neurologic disease status and will participate in 2 longitudinal visits; Screening/baseline Visit 1, and one (1) follow-up which will occur at approximate 12-month interval. Upon IRB approved consent, the study participant will undergo the assessments and bio-fluid collections at each visit as outlined in the Schedule of Events.
The aim of this study is to investigate the role of the combination of volumetric and dissemination parameters obtained from pretreatment 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in predicting the interim response and progression status in patients with Hodgkin lymphoma (HL). Pretreatment PET/CT images of HL patients were analyzed with LIFEx software, and volumes of interest (VOIs) were drawn with a fixed SUV 4.0 threshold. MTV, SUVmax, and TLG values were obtained from each VOI. Total MTV (tMTV) was calculated by summing the MTV values in all VOIs, and similarly, total TLG (tTLG) was obtained by summing the TLG values. The distance between the centers of the lesions was noted as Dmax, and the distance between the outermost voxels of the lesions as DmaxVox. tMTV/DmaxVox was calculated by dividing the tMTV value by the DmaxVox value, and tTLG/DmaxVox was calculated by dividing the tTLG value by the DmaxVox value. The correlation of pretreatment PET parameters with response groups (complete/poor) and relapse/progression status (stable/progressive) was statistically evaluated. A total of 52 patients were included in the study. Bulky disease, tMTV, tTLG, and tMTV/DmaxVox values were found to be significantly higher in the poor response group. tMTV > 190.60 ml was found to be the only prognostic factor predicting interim PET response. The tMTV/DmaxVox and tTLG/DmaxVox showed statistically significant differences between the groups with and without progression. tMTV/DmaxVox > 7.70 was found to be the only prognostic factor in predicting relapse/progression. The evaluation of tumor burden and dissemination together in 18F-FDG PET/CT before treatment in patients with HL can help us to predict the results of the patients.
PURPOSE: This study aims to conduct a thorough analysis, both quantitative and qualitative, of bibliometric parameters related to preemptive analgesia (PA) in oral surgical procedures (OSP).
METHODS: Research trends on PA in OSP using ibuprofen were reviewed through bibliometric analysis of 68 journal articles published from 1991 to 2022 in the Web of Science database. Bibliometric indicators were applied to analyze the journal article data, including the annual distribution of publications and literature growth, document types, citation indicators to measure qualitative research performance, and keyword mapping to identify research trends. The results were imported into RStudio, and the Bibliometrix package was used to prepare and analyze the metadata.
RESULTS: The 68 included articles received a total of 900 citations, ranging from 1 source to 72 citations with some fluctuations. The papers on PA in OSP using ibuprofen had an average of 16.85 citations per paper. These publications were originated from 25 countries, with the highest contributions from Brazil (n = 17), the USA (n = 13), and Turkey (n = 8). The top five major contributing journals were the International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, Journal of Cranio-Maxillo-Facial Surgery, Journal of Periodontology, and Acta Odontologica Scandinavica, representing more than half of all selected papers.
CONCLUSION: Papers focused on PA in OSP received numerous citations. The citation per article correlated with the number of publications at the affiliation, author, country, and journal levels. However, there is still a scarcity of studies in this field.
Participants who have stable disease (no heartburn on the last 7 days of the Run-In Period) will take vonoprazan 10 mg when heartburn occurs during the 6 week On-Demand Treatment Period. Participants can take no more than one dose in a 24 hour period.
This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its related mechanisms. In vivo and in vitro MIRI models were established. Our results showed that activation of PPAR-α decreased the size of the myocardial infarct, maintained cardiac function, and decreased the serum contents of creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and Fe2+ in ischemia/reperfusion (I/R)-treated mice. Additionally, the results of H&E staining, DHE staining, TUNEL staining, and transmission electron microscopy demonstrated that activation of PPAR-α inhibited MIRI-induced heart tissue and mitochondrial damage. It was also found that activation of PPAR-α attenuated MIRI-induced ferroptosis as shown by a reduction in malondialdehyde, total iron, and reactive oxygen species (ROS). In vitro experiments showed that intracellular contents of malondialdehyde, total iron, LDH, reactive oxygen species (ROS), lipid ROS, oxidized glutathione disulphide (GSSG), and Fe2+ were reduced by the activation of PPAR-α in H9c2 cells treated with anoxia/reoxygenation (A/R), while the cell viability and GSH were increased after PPAR-α activation. Additionally, changes in protein levels of the ferroptosis marker further confirmed the beneficial effects of PPAR-α activation on MIRI-induced ferroptosis. Moreover, the results of immunofluorescence and dual-luciferase reporter assay revealed that PPAR-α achieved its activity via binding to the 14-3-3η promoter, promoting its expression level. Moreover, the cardioprotective effects of PPAR-α could be canceled by pAd/14-3-3η-shRNA or Compound C11 (14-3-3η inhibitor). In conclusion, our results indicated that ferroptosis plays a key role in aggravating MIRI, and PPAR-α/14-3-3η pathway-mediated ferroptosis and mitochondrial injury might be an effective therapeutic target against MIRI.
The invention provides a health-preserving back jacket which comprises a back jacket body and medicine bags which are placed in the back jacket body. The back jack body comprises a front sheet and a back sheet. A plurality of pockets are sewed inside the front sheet and the back sheet. A medicine bag is placed in each pocket. Mixed powder and a neodymium iron boron magnet are placed in the medicine bag. The mixed powder is composed of traditional Chinese medicine powder and tourmaline powder. The positions of the plurality of medicine bags in the back jacket body correspond with different internal organs, acupoints, channels and collaterals of human body. The medicine bags placed in the back jacket body comprise a lung nourishing medicine bag, a heart nourishing medicine bag, a liver nourishing medicine bag, a kidney nourishing medicine bag, a spleen-and-stomach nourishing medicine bag, an intestine nourishing medicine bag and acupoint-and-channel-and-collateral nourishing medicine bags. After a person wears the health-preserving back jacket, different medicine bags perform nourishing on different internal organs, acupoints, channels and collaterals of the human body; and the medicine bags directly function on various internal organs, acupoints, channels and collaterals, thereby forming centralized treatment for different diseases, realizing economical performance. The health-preserving back jacket further has advantages of high convenience in wearing and taking-off, no restriction by conditions, no requirement for guidance of medical personnel, and health-preserving effect in an unconscious manner.
FIRAZYR should be inspected visually for particulate matter and discoloration prior to administration. The drug solution should be clear and colorless. Do not administer if the product contains particulates or is discolored.

Attach the provided 25 gauge needle to the syringe hub and screw on securely. Do not use a different needle. Disinfect the injection site and administer FIRAZYR by subcutaneous injection over at least 30 seconds. 

Patients may self-administer FIRAZYR upon recognition of symptoms of an HAE attack after training under the guidance of a healthcare professional [see Patient Counseling Information (17)].
The invention discloses a production method of a black attapulgite traditional Chinese medicine toothpaste. The key point of the technical proposal of the production method is that the method consists of the steps of ingredients preparing, low-speed stirring, crushing and pulping, grinding, high-speed stirring, vacuum degasification and the canning of the finished product. The black attapulgite traditional Chinese medicine toothpaste consists of paste attapulgite clay, carbonized cirsium japonicum, flos sophorae carbonisatus, charred fructus crataegi, charred rhizoma zingiberis recens, charred radix sanguisorbae, imperata cylindrica, charred cacumen platycladi, licorice, lauryl sodium sulfate, potassium sorbate, borneol and deionized water. The black attapulgite traditional Chinese medicine toothpaste has stable chemical structure; the paste does not spill over the tube, no water is separated, the flavor and color is normal, and glassslide does not have any nick. The black attapulgite traditional Chinese medicine toothpaste is soft, fine, clean and even, and can absorb and remove various odors in oral cavity, reduce dental plaque effectively and prevent gum bleeding. The invention is suitable for producing black attapulgite traditional Chinese medicine toothpaste, traditional Chinese medicine toothpaste and other medicinal toothpastes.
A biodegradable, mixed polymeric micelle used to deliver a selected nucleic acid into a targeted host cell contains an amphiphilic polyester-polycation copolymer (12) and an amphiphilic polyester-sugar copolymer (18). The polyester-polycation copolymer (12) forms an electrostatic interaction with polyanionic nucleic acids, and the polyester-sugar copolymer (18) directs the micelle-nucleic acid complex to cells in vivo. Additional copolymers with similar properties may also be included. The composition improves delivery efficiency by providing a particulate gene carrier for which particle size and charge density are easily controlled by multivariate means. Various kinds of ligands and other functional compounds may also be introduced using the composition. The composition may be used in a method for transforming a targeted host cell with a selected nucleic acid.
<P>PROBLEM TO BE SOLVED: To provide a new mannanase, to provide a transformant of the same, and to provide a method for using the same.  <P>SOLUTION: A mannanase gene is cloned by Escherichia coli having a specified amino acid sequence. A transformant of the gene and a method for producing the new mannanase are provided, respectively. An enzyme preparation contains the mannanase, cellulase, protease, lipase, amylase, pectinase, xyloglucanase, or the like. A detergent composition contains the enzyme preparation. The detergent composition is used for treating fibers, waste paper, and a coffee extract, and for cleaning teeth, contact lenses, and personal goods.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
This group will receive an interscalene nerve block. This will be administered as a single 20mL injection consisting of a mixture of 10mL of Exparel and 10mL of 0.5% bupivacaine hydrochloride.
OBJECTIVES: To assess intra-individually visual acuity (VA) and subjective outcome after mix-and-match implantation of a monofocal EDOF IOL and a diffractive trifocal IOL.
METHODS: The monofocal EDOF Isopure IOL was implanted in the dominant eye and the trifocal FineVision HP IOL in the non-dominant eye. Postoperative evaluation included VA at various distances, contrast acuity, monocular defocus curves, decentration and tilt, wavefront aberrometry, VF-7 questionnaire and a halo and glare simulator.
RESULTS: 50 eyes of 25 subjects were enroled. The trifocal IOL performed better at monocular DCNVA (p < 0.01) and at defocus levels of -1.5D to -4.0D (p < 0.01), the monofocal EDOF IOL was better at -0.5D (p = 0.013). No differences in monocular BCDVA, DCIVA, contrast acuity, decentration or tilt were observed (p > 0.05). Wavefront analysis revealed lower HOAs in the trifocal group at 5 mm (p < 0.01) and no difference (p = 0.107) at 3 mm pupil aperture. The monofocal EDOF IOL displayed increased negative SA at 5 mm (p < 0.01) and 3 mm (p < 0.01) pupil diameter. Low values of optical phenomena and satisfying results of the VF-7 questionnaire were obtained.
CONCLUSION: Excellent visual performance and low rates of optical phenomena were achieved after mix-and-match implantation of the monofocal EDOF Isopure IOL and the trifocal FineVision HP IOL. Trifocal IOL implantation in the non-dominant eye may decrease optical disturbing phenomena. Similar results were observed for monocular distance, intermediate and contrast VA. The trifocal IOL provided better monocular near VA. Decentration and tilt and HOAs were low.
Sealed, ingestible soft capsules possessing good barrier properties, and which are suitable for the delivery of therapeutic or nutritional preparations, are constructed from materials obtained from non-animal sources. The soft capsule wall is preferably a multilayered film construction comprising a layer of (I) plasticised hydroxypropyl methyl cellulose (HPMC); (ii) propylene glycol alginate (PAG) and, optionally, (iii) sodium alginate (SA) (see Figure 2, not shown). The HMPC layer is preferably the innermost layer of the multilayered wall construction. The purpose of the PAG layer is to promote adhesion. The most preferred construction comprises an innermost plasticised HMPC layer, an intermediate PAG layer and an outermost SA layer. Alternatively, the capsule wall may be formed form a layer of HMPC coated after formation with gum arabic. It is also possible to form the film layer from a blend of components, for example, a blend of 2 parts HMPC and 1 part PAG may be used to form the innermost layer of the capsule wall, or a blend of 1 part PAG and 1 part HMPC may be used to promote adhesion between the innermost HMPC and outermost SA layers. The film layers used to form the soft capsule wall should be capable of forming and/or sealing using techniques such as vacuum forming or sealing by means of radio frequency, ultrasonics or heat. The sealing properties of the capsule may be improved during its construction by the application of an alcohol such as a glycol, <I>e.g</I>., propylene glycol, a lactone, an acetin, or a pyrrolidone to the film surface being coated.
PURPOSE: To compare the effect of superior and temporal clear corneal incisions, regardless of the steep axis, on postoperative changes in corneal higher order aberrations (HOAs) in patients with healthy corneas and mild preoperative corneal astigmatism.
METHODS: In this prospective cohort study, the right eyes of study participants were randomly assigned to one of two groups prior to cataract surgery: temporal incision (TI) and superior incision (SI). Preoperatively and 6 weeks after surgery, measurements were taken of corneal HOAs over a 6-mm optical zone.
RESULTS: The study included 102 eyes (50 eyes in the TI group and 52 eyes in the SI group) that underwent routine phacoemulsification using a 2.4-mm clear corneal incision. Significant changes in vertical coma (P = .019), horizontal coma (P = .042), and vertical trefoil (P = .001) were observed in the SI group. In the subgroup analysis of the SI group, significant changes in vertical coma (P = .025) and vertical trefoil (P = .047) were observed in the eyes with preoperative with-the-rule corneal astigmatism, and significant changes in horizontal coma (P = .038) were observed in eyes with preoperative against-the-rule corneal astigmatism. The TI group showed no significant difference between the preoperative and postoperative periods.
CONCLUSIONS: The SI induced vertical and horizontal coma in accordance with the preoperative axis of the steep meridian. These alterations in corneal HOAs may affect the quality of vision after surgery. TI may potentially provide an advantage over SI in terms of corneal HOAs. [J Refract Surg. 2024;40(11):e792-e796.].
SYSTANE® Lid Wipes administered to treated eye(s) once a day; SYSTANE® BALANCE lubricant eye drops administered to treated eye(s), 1 drop 4 times a day; SYSTANE® Vitamins, 2 softgels ingested daily. Duration of treatment was 3 months.