anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1467061 Quinoline derivatives CIBA-GEIGY AG 7 May 1974 [11 May 1973 21 March 1974] 20037/74 Heading C2C Novel compounds I (Ph is a 1,2-phenylene radical carrying a cycloaliphatic radical and optionally other substituents; Rx is a free or etherified OH group or an optionally substituted amino group; R 0  is alkyl OH 1-7 C alkoxy or H; R 1  is H, an aliphatic or cycloaliphatic hydrocarbon radical optionally substituted by OH or an araliphatic radical; X is O or S) and salts thereof or their tautomers are prepared by: (1) intramolecular condensation of a compound IV (Z 0  is an esterified or etherified OH group) with elimination of HZ 0 ; (2) conversion of a radical Z into the group CORx in a compound V (Z is a functionally modified COOH group, other than an ester or amide group, which can be converted to -COR x  by hydrolysis, alcoholysis or aminolysis (ammonolysis) or Z is acetyl which can be oxidized to COOH); (3) intramolecular condensation of a compound VI (R x  is etherified OH or amino; one of Z 1  and Z 2  is -COA and the other is H; A is H, 1-4 C alkyl, halo, alkoxy, azido or together with the COOH group forms an anhydride or imide group); (4) cyclization of a compound VIII (one of R x <SP>1</SP> and R x <SP>2</SP> is 1-4 C alkoxy and the other is CH 2 COR x ) to give a compound I where X is O, R 0  is OH and R x  is etherified OH; (5) conversion of a radical Z 3  into the oxo or OH group by hydrolysis of a compound IX (Z 3  is a functionally modified oxo group; or in the tautomer Z 8  is reactive esterified hydroxyl) ; (6) conversion of the group SY by hydrolysis into -SH in a compound X or XI (-SY is -G-C(NH 2 )=NH; -S-CO-R or -S-CS-R; and R is 1-7 C alkyl or phenyl- 1-4 C alkyl); or (7) reaction of a compound XII or XIIa (Y 1  is halo, ammonium or 1-4 C alkylsulphonyl) or a salt thereof with an alkali metal sulphide or bisulphide. Other conventional modifications, racemisations and salt formations are also described.  Compounds IV may be prepared by reaction of a compound IVa with a compound IVb (Z 0 <SP>1</SP> is alkoxy). Compounds V may be prepared by cyclization of compounds Va Compounds VIII may be prepared by reaction of a compound VIIIa with a compound Rx<SP>11</SP>-CO-CH 2 -CORx (Rx<SP>11</SP> is halo). Compounds IX may be prepared by cyclization of a compound IXa (Rx<SP>1</SP> is etherified OH). Pharmaceutical compositions useful as antimicrobial, analgesic and antiinflammatory agents comprise a compound I together with a suitable carrier or diluent.  Fungicidal compositions and bactericidal compositions comprise a compound I together with suitable bases.
Discontinuation symptoms have been systematically and prospectively evaluated in patients treated with desvenlafaxine during clinical studies in Major Depressive Disorder. Abrupt discontinuation or dose reduction has been associated with the appearance of new symptoms that include dizziness, nausea, headache, irritability, insomnia, diarrhea, anxiety, fatigue, abnormal dreams, and hyperhidrosis. In general, discontinuation events occurred more frequently with longer duration of therapy. 

  


During marketing of SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors), and SSRIs (Selective Serotonin Reuptake Inhibitors), there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures. While these events are generally self-limiting, there have been reports of serious discontinuation symptoms. 

  


Patients should be monitored for these symptoms when discontinuing treatment with desvenlafaxine. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose, but at a more gradual rate [see Dosage and Administration (2.4) and Adverse Reactions (6.1)].
The goal of this study was to investigate sentence-level reading circuits in deaf native signers, a unique group of deaf people who are immersed in a fully accessible linguistic environment from birth, and hearing readers. Task-based fMRI, functional connectivity and lateralization analyses were conducted. Both groups exhibited overlapping brain activity in the left-hemispheric perisylvian regions in response to a semantic sentence task. We found increased activity in left occipitotemporal and right frontal and temporal regions in deaf readers. Lateralization analyses did not confirm more rightward asymmetry in deaf individuals. Deaf readers exhibited weaker functional connectivity between inferior frontal and middle temporal gyri and enhanced coupling between temporal and insular cortex. In conclusion, despite the shared functional activity within the semantic reading network across both groups, our results suggest greater reliance on cognitive control processes for deaf readers, possibly resulting in greater effort required to perform the task in this group.
OBJECTIVE: This study aims to discuss the characteristics and treatment methods of malignant tumors in the parotid region, as well as the therapeutic effects of immediate free flap reconstruction of soft tissue for postoperative defects.
MATERIALS AND METHODS: A retrospective review was conducted on 11 cases of soft tissue flap reconstruction for postoperative defects following the resection of malignant tumors in the parotid region. Statistical analysis was performed based on clinical data.
RESULTS: Among the 11 cases of malignant tumors in the parotid region, there were 2 cases of secretory carcinoma (SC) of the salivary gland, 2 cases of squamous cell carcinoma (SCC), 2 cases of carcinosarcoma, 1 case of mucoepidermoid carcinoma (MEC), 1 case of epithelial-myoepithelial carcinoma (EMC), 1 case of salivary duct carcinoma (SDC), 1 case of basal cell carcinoma (BCC), and 1 case of osteosarcoma. Among these cases, 4 were initial diagnoses and 7 were recurrent tumors. The defect repairs involved: 8 cases with anterolateral thigh free flap (ALTF), 2 cases with pectoralis major muscle flaps, and 1 case with forearm flap. The size of the flaps ranged from approximately 1 cm × 3 cm to 7 cm × 15 cm. The recipient vessels included: 4 cases with the facial artery, 4 cases with the superior thyroid artery, and 1 case with the external carotid artery. The ratio of recipient vein anastomosis was: 57% for branches of the internal jugular vein, 29% for the facial vein, and 14% for the external jugular vein. Among the 8 cases that underwent neck lymph node dissection, one case showed lymph node metastasis on pathological examination. In the initial diagnosis cases, 2 cases received postoperative radiotherapy, and 1 case received 125I seed implantation therapeutic treatment after experiencing two recurrences. Postoperative follow-up revealed that 2 cases underwent reoperation due to local tumor recurrence, and there were 2 cases lost to follow-up. The survival outcomes after treatment included: one case of distant metastasis and one case of death from non-cancerous diseases.
CONCLUSION: Immediate soft tissue flap reconstruction is an important and valuable option to address postoperative defects in patients afflicted with malignant tumors in the parotid region.
PURPOSE:To prepare the title molding usable safely for a long term and having a widely changeable antibacterial power by depositing an antibacterial metal on a calcium ceramic, backing and powdering the ceramic, compounding the powdered ceramic into a polyolefin resin, and molding the resulting compsn. CONSTITUTION:On a calcium ceramic selected from the group consisting of calcium phosphate, calcium carbonate, calcium silicate, and hydroxyapatite an antibacterial metal selected from the group consisting of silver, copper, and zinc. is deposited. The ceramic is then backed at 800 deg.C or higher and powdered into particles with a mean particle size of 10mum or lower. A polyolefin resin is compounded with the ceramic powder in an amt. of at least 0.03wt.% based on the resulting compsn., and molded to give the title molding. As the metal, silver and zinc are esp. pref., and an esp. pref. calcium ceramic is hydroxyapatite.
Non-diabetic individuals matched for age, gender and physical activity are recruited as control subjects to establish a reference level likely to image the cases before they experienced their knee injury. Blood- and urine sampling, OGTT and DXA scans will be carried out 1-3 times for each control subject. No lifestyle intervention is implemented.
The pulp therapy in primary teeth is designed to eliminate the infection and keep the tooth in a functional state until its natural exfoliation. An important step for the success of endodontic therapy is the final restoration, which must seal the tooth, avoiding new contamination. Thus, this study proposes to carry out a randomized clinical trial with longitudinal follow-up of two years, in order to compare the degree of success of endodontic treatment in primary teeth restored with two different techniques: composite resin (Filtek Bulk Fill - 3M ESPE) or stainless steel crowns (3M ESPE). Success will be measured by clinical and radiographic features of primary teeth treated with the different restorations after 1, 6, 12 and 24 months. Among the secondary outcomes that will be assessed are the quality and durability of restorations and the cost benefit of treatments. Patients who seek the university clinics and require endodontic treatment will be invited to participate. The sample unit is the tooth and these will be randomized in groups through a randomization list created and distributed in sequential opaque envelopes. The envelope will be opened only after the end of endodontic treatment (made with Guedes-Pinto paste), to ensure allocation concealment. The data will be statistically analyzed using the Stata 12.0 (Stata Corporation, College Station, TX, USA). The longevity of the treatments will be evaluated by estimating survival rates using the Kaplan-Meier method. Differences between survival rates according to the type of endodontic proposed treatment will be analyzed using the log-rank test. All other clinical variables will be analized using Cox regression. The significance level for all analyzes will be 5%.
FIELD: medicine, orthopedic stomatology. SUBSTANCE: composition for dentures contains vinyl chloride copolymer with butyl acrylate, dibutyl phthalate, additionally it contains epoxidated soybean oil. Components should be taken at certain quantitative content. The composition provides increased physicomechanical properties and decreases allergic reactions in mouth cavity. EFFECT: higher efficiency. 1 cl, 1 tbl
PURPOSE: A diet composition and diet powder, gum, and film manufactured using the same are provided to ensure stability without side effect of diet. CONSTITUTION: A diet composition(20) contains 100 weight parts of liquid composition and 4-12 carbohydrate. The liquid composition contains 100 weight parts of water, 0.02-2 weight parts of aids, 0.001-0.5 weight parts of flavoring agent, and 0.1-5 weight parts of buffer. The aids are silicon dioxide and the beffer is urea, organic salt, or inorganic salt. The carbohydrate is sucrose, maltose, isomaltose, maltodextrin, glucose, galactos, trehalose, fructo oligosacchriades, beta glucane, or triose. Diet gum contains 10-20 weight parts of the diet composition and 80-90 weight parts of gum base. A diet film contains 0.1-10 weight parts of the diet composition, 80-90 weight parts of water soluble film, 5-10 weight parts of surfactant, and 5-20 weight parts of plasticizer.
Children's academic success across a range of domains is related to their executive function skills - specifically by their ability to maintain and update information (working memory) and to suppress inappropriate responses (inhibitory control). These skills undergo significant development during the preschool years. Notably, preschool executive function skills strongly predict school readiness, as well as concurrent and later academic achievements in mathematics. The aim of this project is to test an intervention that is specifically designed to improve preschoolers' executive functions - crucially, before the achievement gap sets in. The study will be carried out, following CONSORT (2010) guidelines, with typically developing preschoolers (aged approximately 4 years of age). The study will include children from socioeconomically advantaged and disadvantaged families. Children will be randomly assigned to either an executive function training group or an active control group. A nominated person external to the project will conduct the random allocation process. The random allocation will be done for each nursery to ensure roughly even numbers in each group from each nursery. Children in both groups will complete computerized tasks lasting 15-20 minutes once a week for four weeks. The investigators will compare the trained children to an active control group that closely matches the training in terms of activity. To check for improvements, the investigators will measure cognitive and maths skills at baseline (one week before training); one week post-training; three months post-training; and one year post-training. These assessments will be conducted by testers blind to the child's group.
Introduction: Elevations in serum ferritin and serum iron occur during pediatric extracorporeal membrane oxygenation (ECMO). Previous reports attribute the elevation to frequent red blood cell transfusions and/or hemolysis. Chronic transfusion can cause iron deposition in tissues leading to multisystem organ dysfunction. This study aims identify clinical factors associated with elevated ferritin and iron in pediatric ECMO patients, along with post-decannulation magnetic resonance imaging (MRI) assessment of iron deposition in liver and brain.Methods: Prospective, pilot study, using descriptive statistics to investigate potential associations between patient characteristics, serum ferritin and iron levels, and post-decannulation hepatic and basal ganglia iron deposition.Results: In this study, nine patients (100%) had elevated serum ferritin levels during ECMO. High ferritin levels were more common with veno-arterial than with veno-venous cannulation (p = 0.026) and were also associated with high plasma free hemoglobin levels (p < 0.001). Five patients presented with elevated serum iron levels. High serum iron levels were associated with higher daily (p = 0.016) and cumulative transfusion volumes (p = 0.013) as well ECMO duration beyond 7 days. MRI scans were performed on three patients with no evidence of abnormal iron deposition detected in the liver or brain.Conclusions: This pilot study shows that during pediatric ECMO, elevations in serum ferritin and serum iron occur and those elevations may be related to the cannulation modality, ECMO duration, amount of hemolysis, and volume of red blood cell transfusions. Further investigation is warranted to fully understand the implications of elevated serum iron and ferritin in pediatric ECMO.
To provide a composition having good tactile, and excellent in particle dispersibility, and a production method of the same.SOLUTION: A composition includes: a cellulose derivative particle; and a surface treatment compound. The average particle size of the cellulose derivative particle is 0.08 μm or more and 100 μm or less. The surface treatment compound is an organic compound having a long-chain alkyl group and/or an inorganic powder. The average particle size of the inorganic powder is 1/3 or less of an average particle size of the cellulose derivative particle. A cosmetic composition contains the composition. A production method of the composition includes a mixing process of subjecting the cellulose derivative particle and the surface treatment compound to dry mixing.SELECTED DRAWING: Figure 1
WAKE-UP is a clinical trial of MRI based thrombolysis in acute stroke patients with unknown time of symptom onset, e.g. due to recognition of stroke symptoms on awakening. Intravenous thrombolysis with Alteplase is available as effective and safe treatment of acute stroke within 4.5 hours of symptom onset. However, in about 20% of acute stroke patients time of symptom onset is unknown. This large group of patients is currently excluded from treatment with Alteplase. The objective of the research proposed in the WAKE-UP project is to provide effective treatment options for this large group of acute stroke patients.

WAKE-UP is designed to prove efficacy and safety of MRI-based intravenous thrombolysis with Alteplase in patients waking up with stroke symptoms or patients with otherwise unknown symptom onset. Patients will be enrolled based on MRI findings indicative of acute ischemic stroke less than 4.5 hours of age.
PURPOSE:To obtain the subject pharmaceutical preparation, containing povidone iodine, having a moderate viscosity used for gingivitis, pyorrhea alveolaris and stomatitis and good in taste and preservation stability for a long period. CONSTITUTION:This semipaste pharmaceutical preparation for the oral cavity contains at least potassium iodide in an amount of 0-50 pts.wt. based on 1 pt.wt. povidone iodine, a sugaralcohol which is oligosaccharides as a base and a stabilizer in an amount of 1-300 pts.wt. based on 1 pt.wt. povidone iodine and the povidone iodine in an amount of 0.1-20wt.% based on the total weight of the pharmaceutical preparation.
Growth-associated protein 43 (GAP-43) is found in the axonal terminal of neurons in the limbic system, which is affected in people with Alzheimer's disease (AD). We assumed GAP-43 may contribute to AD progression and serve as a biomarker. So, in a two-year follow-up study, we assessed GAP-43 changes and whether they are correlated with tensor-based morphometry (TBM) findings in patients with mild cognitive impairment (MCI). We included MCI and cognitively normal (CN) people with available baseline and follow-up cerebrospinal fluid (CSF) GAP-43 and TBM findings from the ADNI database. We assessed the difference between the two groups and correlations in each group at each time point. CSF GAP-43 and TBM measures were similar in the two study groups in all time points, except for the accelerated anatomical region of interest (ROI) of CN subjects that were significantly greater than those of MCI. The only significant correlations with GAP-43 observed were those inverse correlations with accelerated and non-accelerated anatomical ROI in MCI subjects at baseline. Plus, all TBM metrics decreased significantly in all study groups during the follow-up in contrast to CSF GAP-43 levels. Our study revealed significant associations between CSF GAP-43 levels and TBM indices among people of the AD spectrum.
Dysregulated transcription due to disruption in histone lysine methylation dynamics is an established contributor to tumorigenesis1,2. However, whether analogous pathologic epigenetic mechanisms act directly on the ribosome to advance oncogenesis is unclear. Here we find that trimethylation of the core ribosomal protein L40 (rpL40) at lysine 22 (rpL40K22me3) by the lysine methyltransferase SMYD5 regulates mRNA translation output to promote malignant progression of gastric adenocarcinoma (GAC) with lethal peritoneal ascites. A biochemical-proteomics strategy identifies the monoubiquitin fusion protein partner rpL40 (ref. 3) as the principal physiological substrate of SMYD5 across diverse samples. Inhibiting the SMYD5-rpL40K22me3 axis in GAC cell lines reprogrammes protein synthesis to attenuate oncogenic gene expression signatures. SMYD5 and rpL40K22me3 are upregulated in samples from patients with GAC and negatively correlate with clinical outcomes. SMYD5 ablation in vivo in familial and sporadic mouse models of malignant GAC blocks metastatic disease, including peritoneal carcinomatosis. Suppressing SMYD5 methylation of rpL40 inhibits human cancer cell and patient-derived GAC xenograft growth and renders them hypersensitive to inhibitors of PI3K and mTOR. Finally, combining SMYD5 depletion with PI3K-mTOR inhibition and chimeric antigen receptor T cell administration cures an otherwise lethal in vivo mouse model of aggressive GAC-derived peritoneal carcinomatosis. Together, our work uncovers a ribosome-based epigenetic mechanism that facilitates the evolution of malignant GAC and proposes SMYD5 targeting as part of a potential combination therapy to treat this cancer.
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to surgery, and can be used to treat mammary gland cysts. Perform a percutaneous puncture of the mammary gland cyst under ultrasound control, aspirate the contents of the cyst, introduction of a sclerosing agent into the mammary gland cyst, followed by the application of a sterile pressure bandage for a day. In this case, 1 % sodium tetradecyl sulfate solution is used as a sclerosing agent. In the mammary gland cyst, up to 20 mm in size, administer 0.25 ml of this preparation. In a cyst of 21 to 30 mm – administer 0.5 ml of the drug, and in the cyst of 31 mm and above – administer 1.0 ml of the drug. And in one session, perform sclerosing no more than six cysts.EFFECT: method makes it possible to reduce the invasiveness of the surgical operation, eliminate the risk of severe postoperative complications and relapse of the disease, and simultaneously treat multilocular and recurrent cysts of the mammary gland.1 cl, 2 ex
The elderly population in West Java Province with the age category of 60-64 years is 1.76 million people. Experts estimate that 25.2% of the Indonesian population experiences frailty. Frailty can lead to a variety of worsening health conditions. The frailty process is thought to stem from the failure of various mechanisms associated with markers of aging. Markers of aging are divided into three categories: primary, antagonistic and integrative. Biomarkers representing these three categories are global DNA methylation, GDF15 and Lamin A COP. Multicomponent exercise is the most effective intervention in elderly with frailty. Elderly people in West Java on average only have an education equivalent to junior high school (SMP), so activities that promote physical activity are better focused on health activities in the community. The poco-poco exercise that is currently commonly practiced almost fulfills the rules of multicomponent exercise for frailty elderly, but poco-poco exercise does not have a muscle strengthening exercise component, so a modified poco-pcoco exercise was created to fulfill this method.
The present invention relates to a cosmetic composition for ameliorating skin elasticity and reducing wrinkles, containing an extract of Juncus effusus var. decipiens Buchenau. as an active ingredient. The composition of the present invention exhibits excellent effects of inhibiting elastase and collagenase activities, and also prevents a loss of skin elasticity and wrinkle formation, thereby showing superior effects of ameliorating skin elasticity and reducing wrinkles. The extract of Juncus effusus var. decipiens Buchenau. is extracted by a solvent which is selected from water, lower alcohol with 1 to 4 carbon atoms, and a mixed solvent of both.