anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
After initiation of invasive mechanical ventilation, initial ventilator settings were performed by the attending physician. These settings include titration of best PEEP to promote oxygenation if Spo2 \<92% despite a Fio2 higher than 80% or best compliance that do not jeopardize oxygenation if Fio2 is between 50-80% and Spo2 \>92%. After a period of 30 minutes for stabilisation, the first set of measurements were done in the SP1 position. Afterwards, the patient was turned to prone position with the same PEEP (which was unchanged throughout the study period) and measurements were repeated every four hours until the patient was reverted back to SP2. Eventually, there were 7 measurements in total. (SP1, PP0, PP4, PP8, PP12, PP16, SP2). Dead space ventilation and shunt fraction calculations were made based on central venous blood gas measurements and oxygen consumption and carbon dioxide production at the relevant timepoint.
A method for preparing streptogramines of general formula (I), wherein Ri is methyl or ethyl, R2 is H and X and Y togemei form an oxo radical or Ri is ethyl. R2 and X are H and Y is Hor OH, or else R1 is ethyl. R2 is OH and X and Y together form an oxo radical, by demethylating a synergistin derivative of general formula (II). wherein RI. R2. X and Y are as defined abovc, by means of a treatment with a periodate in an acetic medium, follow by a treatment in an aqueous medium.
Part B will be comprised of up to 50 healthy participants over 5 cohorts of 10. Each participant will receive 14 oral doses of TLC-2716 or placebo over 14 days (given once daily) at different dose levels (1 cohort per dose level).
Disclosed systems and methods relate to concussion detection and reporting. In an example, a method involves receiving sensor data from an accelerometer. The method further involves determining an impact acceleration from the sensor data and comparing the impact acceleration to a threshold value. The threshold value may be adjustable based on a user's age. When the impact acceleration is less than the threshold value, the method involves transmitting the sensor data to a server. When the impact acceleration equals or exceeds the threshold value, the method involves transmitting an alert and transmitting the sensor data to a server.
Induction of β-cell neogenesis has been associated with ductal epithelium, however ˜80% of the pancreas is composed of acinar cells. Surprisingly, pancreatic acinar cells contribute to β-cell neogenesis. Partial duct obstruction (PDO) of the pancreas is a known inducer of β-cell neogenesis leading to expansion of β-cell mass, and the effect appears to be mediated by INGAP, an acinar cell protein originally identified in the regenerating hamster pancreas. We examined the effects of PDO on the incorporation of tritiated thymidine by acinar and β-cells of the pancreas in female Syrian hamsters. A single dose of tritiated thymidine was administered to all animals 2 weeks after PDO. Animals were then sacrificed at 1 hr, or at 6 weeks post-injection. Tritiated thymidine incorporation into acinar cells was highest at 2 weeks after PDO and declined at 8 weeks after PDO. Incorporation of tritiated thymidine into β-cells was inversely related to that observed in acinar cells. Two weeks following PDO, β-cell tritiated thymidine uptake was relatively low and it increased significantly at 8 weeks after PDO, consistent with β-cell neogenesis from an acinar cell origin. Electron microscopy demonstrated cells with both zymogen and endocrine granules, further suggesting acinar to endocrine cell transdifferentiation. In a second experiment, hamsters were administered either a pentadecapeptide of INGAP protein or an equivalent volume of saline for 10 days. There was a 2-fold increase in the number of extra-islet acinar-associated β-cell clusters in the INGAP peptide-treated hamsters resulting in a 2.8-fold increase in the overall extra-islet β-cell mass. Acinar-to-β-cell differentiation provides an alternate pathway to β-cell neogenesis; INGAP peptide plays a significant role in this process.
Patients with clinical suspicion of lung lesions were recruited for FDG PET/CT. Based on the PET/CT findings and clinical details a PET/CT guided biopsy was planned. The patients were assigned to the two arms. In the first arm, participants underwent a robotic-assisted biopsy. In the second arm, participants underwent PET/CT-directed CT fluoroscopy-guided lung biopsy. The biopsy planning including patient positioning was done after F18-FDG PET/CT whole body or regional imaging of the patient. Written consent was obtained and the patient will be prepared for the biopsy. Lung biopsies were done using a semi-automatic biopsy gun under the imaging guidance (PET fused CT fluoroscopy) following aseptic precautions. Follow-up CT scans were taken post-biopsy. The time consumed for the procedure, radiation exposure to the interventionist, complications and diagnostic yield in both the arms were compared.
This is a prospective, mulitiple-center clinical trial initiated by the investigator. LungBrella marker can be accurately implanted into a predetermined position in the lung assisted by JediVision software and successfully marked the pulmonary nodules which needs to undergo Video-assisted thoracoscopic surgery. The study is expected to enroll 90 patients. Finally, the effectiveness and safety of the method will be evaluated. This method not only can complete pulmonary nodule localization in the operating room without occupying the resources of radiology department, but also can let patients receive pulmonary nodule location after anesthesia. Thereby the risks during transportation are avoided and the suffering of patients is reduced.
The present invention provides one electrotherapy system of cloud-based electrical stimulation frequency spectrum which contains a remote platform equipped with a server. This server connects a data module and a system database. The system database includes a frequency spectrum database and a functional database. That frequency spectrum database store at least one electrical stimulation frequency spectrum and that functional database also store the corresponding functional mode of the said electrical stimulation frequency spectrum. One electrotherapy device bonded with a communication unit and also equipped with a user interface to correspondingly present the said functional mode. Besides, the communication unit downloads and transports the said electrical stimulation frequency spectrum to the electrotherapy device via selecting at least one functional mode to accordingly process electrical stimulation to the said electrical stimulation frequency spectrum. Thus, the present invention is able to store electrical stimulation frequency spectrum and its corresponding functional mode in remote platform to make users can download electrical stimulation frequency spectrum according to their need or remote diagnosis result to undergo electrotherapy. It could not only help users expand electrotherapy function of electrotherapy device by their need but also give users correct electrical stimulation therapy through remote medical treatment to enhance the convenience of medical diagnosis and electrotherapy. It also benefits to build the remote medical system and can cooperate with the long-term care policy and need of government.
Participants with B-NHL will receive loncastuximab tesirine in combination with glofitamab at the MTD and/or RDE if favorable results of Part 1 are received. In addition participants will receive obinutuzumab pre-treatment 1000 mg on C1 D1.
The Stress Management Program will utilize a smart phone app, accelerometers, telephone coaching, and behavioral incentives to target stress, relaxation, and sleep. Participants will wear accelerometers, log hours slept, enter real-time information about their relaxation exercises and stress, and monitor 3 goal thermometers (sleep, relaxation, stress) to meet behavioral targets. The Stress Management Program, including the use of the app and assessments, is identical to the Adapted MBC2 program, with the exception of the content.
The patients in group C underwent ultrasound guided caudal block for postoperative analgesia. By placing the patients in the lateral decubitus position, the linear ultrasound probe was placed longitudinally on the sterilized area on the midline of the sacrum, and access was provided with a 2.5 cm 22 gauge needle on the dorsal skin of the sacral hiatus at a 90° position. The sacrococcygeal ligament was crossed, the needle was oriented approximately 25° and advanced approximately 2 to 3 mm to reach the sacral canal. When it was understood that the sacral hiatus had been entered, 0.5 mL kg-1 0.25% bupivacaine was injected by aspirating every 2 mL after the location was confirmed with the negative aspiration method.
Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.
The Preventiometer is a physical wellness tool that assesses multiple physical wellness measures in a 60 ± 15 minutes period of time. It is intended to promote population wellness by empowering individuals to act upon the information they receive about their overall health.
PURPOSE:To obtain a therapeutic agent for osteoporosis, containing an eicosapentaenoic acid or its derivative as an active ingredient and useful for treating and preventing the osteoporosis with hardly any side effects. CONSTITUTION:A therapeutic agent for osteoporosis containing a compound expressed by formula I (R is H, K, Na, Ca, etc.) or its derivative as an active ingredient. For example, all-cis-5,8,11,14,17-eicosapentaenoic acid (hereinafter abbreviated to EPA), EPA methyl ester, EPA ethyl ester, EPA potassium salt, etc., are cited as the compound expressed by formula I. A compound having a group expressed by formula II in the molecule may be used as the compound expressed by formula I. The aforementioned therapeutic agent can orally or parenterally be administered. Oral administration thereof in the form of tablet, capsule, etc., can be carried out or parenteral administration can be performed by injection, etc., in the form of a liquid formulation such as its solution or emulsion.
Conjugate comprising an interleukin-10 (IL-10) polypeptide and a polymer. The IL-10 has at least one cyteine residue introduced (by substitution) in a position selected form 89 positions. The polymer (e.g. PEG) is attached to cysteine residue of the polypeptide. The conjugate exhibits immunosuppressive activity on T cells, B cells or antigen presenting cells. The conjugate should exhibit a reduced immunostimulatory activity compared to hIL-10. Use of said conjugate for treating inflammatory or autoimmune disease.
OBJECTIVES: To study each atypical feature in atypical meningioma versus other grade 2 meningiomas and its possible relation to recurrence.
METHODS: This is a retrospective study of patients with WHO grade 2 meningioma operated in our institution between 01/2008 and 12/2020. The rate of recurrence, reoperation and readmission were recorded during the follow-up period. A statistical analysis was done to determine the significance of each pathological feature in regard to recurrence.
RESULTS: A total of 74 patients were included as WHO grade 2 meningioma with 60 (81%) patients having an AM and 14 (19%) patients with chordoid or clear cell meningioma. The mean age was 51 years±14. The most common location was meningioma abutting the frontal lobe (convexity). Major atypical features were more noted in the AM, however, there was no significant difference between AM and other types of meningioma. Increased Nuclear cytoplasmic ratio and cellularity were found significantly more in AM. The recurrence rate was 16.2%. No specific pathology feature (major or minor) nor the type of Grade 2 meningioma was significantly related to recurrence.
CONCLUSION: The types of WHO grade 2 meningiomas have similar prognosis and recurrence rates. There is no significant difference between the atypical features in indicating a more aggressive nature or risk of recurrence in grade 2 meningiomas.
This is an open label phase 2 study using metronomic doses of trabectedin, gemcitabine and dacarbazine given intravenously.

A total of 80 patients will receive trabectedin 0.5 mg/m2 as 24 hour continuous intravenous infusion (CIV) on D1 and D8, gemcitabine 250 mg/m2 i.v. on D1 and D8, and dacarbazine 250 mg/m2 i.v. on D1 and D8 (see product information; www.accessdata.fda.gov). Treatment cycles are given every 3 weeks. Patients in this study may continue treatment until significant disease progression or unacceptable toxicity occurs up to one year of therapy. Patients who withdraw or do not complete the first 2 treatment cycles and first follow up CT scan/MRI will be replaced.
Dexamethasone orally at a dose of 40 mg qd for 4 days. Patients who do not respond to the treatment may receive another cycle of high-dose dexamethasone therapy with an interval of 10 days.
Methods, software and devices for automatically constructing a structured electronic representation of a user-fillable form are disclosed. Each structured electronic representation is constructed from a parsable version of that form. A plurality of data structures for constructing structured electronic representations of user-fillable forms is stored. Each of the data structures is representative of a form region of one of a plurality of pre-defined types. A parsable version of the user-fillable form is received. This parsable version is parsed to identify fields of the user-fillable form, including at least one text field and at least one input field. These fields are grouped to form a plurality of form regions. Each of these form regions is matched to one of the stored data structures that best represents the form region in a structured electronic representation. An indicator of each matched data structure is stored.
PURPOSE: To provide comprehensive information about the anterolateral ligament (ALL) prevalence, morphometry, isometry, insertions, histology, and its relationship with the lateral meniscus (LM).
METHODS: The study was performed, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Eligible cadaveric studies investigating the frequency of the ALL presence, and anatomical features were identified through an online search of the PubMed, Scopus, and Cochrane Central databases from inception to June 2022. Statistical analysis was conducted with the open-source R programming language using the "meta" package. The Higgins I2 statistic was used for quantifying heterogeneity.
RESULTS: Thirty-three studies (1,478 cadaveric knees) were included. The ALL had a 79% prevalence. It was attached to the LM periphery in 97% of studies. Most studies reported a femoral insertion of the ALL, just proximal and posterior to the lateral epicondyle. Tibial attachment is constant at the midpoint between Gerdy's tubercle and fibular head. The mean ALL thickness at the joint line was 1.6 [1.2; 2.0] mm. The ALL length was found to significantly change across the knee flexion (P < .01). It was increased from 0° to 60° and decreased after 60° flexion. Seven histological studies demonstrated a typical ligamentous microstructure.
CONCLUSION: The ALL is a thin ligament, distinct to the knee capsule, which may be found in 79% of the knees having an almost constant attachment to the LM. The ALL is not isometric. It becomes tense during internal rotation and between 30° and 60° knee flexion. Pooled results should be interpreted with caution due to the high heterogeneity among the included studies.
CLINICAL RELEVANCE: This study sheds light on controversial issues and provides comprehensive and accurate information about the essential anatomical knowledge on ALL, which may contribute to optimizing ALL reconstruction surgical techniques and biomechanical settings.
Aging (senescence) is an unavoidable biological process that results in visible manifestations in all cutaneous tissues, including scalp skin and hair follicles. Previously, we evaluated the molecular function of adenosine in promoting alopecia treatment in vitro. To elucidate the differences in the molecular mechanisms between minoxidil (MNX) and adenosine, gene expression changes in dermal papilla cells were examined. The androgen receptor (AR) pathway was identified as a candidate target of adenosine for hair growth, and the anti-androgenic activity of adenosine was examined in vitro. In addition, ex vivo examination of human hair follicle organ cultures revealed that adenosine potently elongated the anagen stage. According to the severity of alopecia, the ratio of the two peaks (terminal hair area/vellus hair area) decreased continuously. We further investigated the adenosine hair growth promoting effect in vivo to examine the hair thickness growth effects of topical 5% MNX and the adenosine complex (0.75% adenosine, 1% penthenol, and 2% niacinamide; APN) in vivo. After 4 months of administration, both the MNX and APN group showed significant increases in hair density (MNX + 5.01% (p < 0.01), APN + 6.20% (p < 0.001)) and thickness (MNX + 5.14% (p < 0.001), APN + 10.32% (p < 0.001)). The inhibition of AR signaling via adenosine could have contributed to hair thickness growth. We suggest that the anti-androgenic effect of adenosine, along with the evaluation of hair thickness distribution, could help us to understand hair physiology and to investigate new approaches for drug development.
Participants will receive a virtual counselor intervention for smoking cessation, be offered the opportunity to utilize nicotine replacement therapies, participate in shared decision-making around lung cancer screening, and be supported by a community health worker. Participants will be followed for a total of 6 months. Assessments will be conducted at baseline, 1 month, 3 months, and 6 months.
The invention discloses a composition for reducing poly-glycine-alanine aggregation and alleviating behavioral deficits, at least comprising UBQLN2 and/or 17AAG, and HSP 70. The invention also discloses application of the composition in treating amyotrophic lateral sclerosis and frontotemporal dementia, wherein the composition is the composition. In the present invention, UBQLN2 is capable of reducing poly-GA aggregation and alleviating poly-GA-induced neurotoxicity. Furthermore, UBQLN2 can reduce polyGA aggregates regardless of polyGA substrate ubiquitination status. UBQLN2 was able to recognize HSP70 ubiquitination, promote the formation of UBQLN2-HSP70-GA complex and promote poly-GA degradation. Blockade of UBQLN2 interaction with HSP70 inhibited poly GA aggregation in C9-ALS/FTD-iPSC derived neurons. Enhancement of HSP70 in adulthood with compound 17AAG can rescue behavioral deficits in poly-GA animals.
Genome-wide association studies (GWAS) have identified coronary artery disease (CAD) susceptibility locus on chromosome 3q22.3. This locus contains a cluster of several genes that includes muscle rat sarcoma virus (MRAS). Common MRAS variants are also associated with CAD causing risk factors such as hypertension, dyslipidemia, obesity, and type II diabetes. The MRAS gene is an oncogene that encodes a membrane-bound small GTPase. It is involved in a variety of signaling pathways, regulating cell differentiation and cell survival (mitogen-activated protein kinase [MAPK]/extracellular signal-regulated kinase and phosphatidylinositol 3-kinase) as well as acute phase response signaling (tumor necrosis factor [TNF] and interleukin 6 [IL6] signaling). In this review, we will summarize the role of genetic MRAS variants in the etiology of CAD and its comorbidities with the focus on tissue distribution of MRAS isoforms, cell type/tissue specificity, and mode of action of single nucleotide variants in MRAS associated complex traits. Finally, we postulate that CAD risk variants in the MRAS locus are specific to smooth muscle cells and lead to higher levels of MRAS, particularly in arterial and cardiac tissue, resulting in MAPK-dependent tissue hypertrophy or hyperplasia.
The present application relates to healthcare services at a hospital and more specifically to a configurable logic module for an electronic health records application that is used to deliver early warning score calculations. There is perceived to be an alert fatigue associated with false alarms triggered by conventional EWS calculations. The present application therefore proposes more accurate calculations which not only incorporate physical patient observations but also factor in other parameters such as medication, treatments, medical history, etc in an effort to normalise the patients observations and thereby reduce the number of false alarms. The claims define a computerised method for publishing patient observations from a user device to an asynchronous web service. The method utilises a publish subscribe messaging pattern which is supported by most well known messaging services and manages multiple submission transaction requests for a single patient observation session. Preferably, the transactions and their results are managed by the application, and appropriate result events (success, partial failure and full failure) are pushed back to a user interface.
The invention relates to preserved Chinese yam and a preparation method thereof. The preserved Chinese yam takes Chinese yam as material and contains 70-150 shares of Chinese yam, 50-80 shares of sucrose, 0.15-0.3 shares of sodium sulfite, and 0.1-0.2 shares of citric acid. During manufacturing, the material is selected, washed, and cut; then the material is processed with sulfate, heated in hot water, taken out, and cooled, with water dropped; the sucrose solution is added with the citric acid, and the material is preserved in sugar and then is boiled in sugar for twice; the Chinese yam is taken out, with sugar solution dropped, and is dried, and packed, thus obtaining the preserved Chinese yam. The manufacture process is reliable and the preserved rehmanniae can be produced by using the current production condition of the preserved fruit. The preserved Chinese yam made by the invention is sweet and delicious in taste. At the same time, the food keeps a plurality of dietary fibers, vitamins and amino acids in Chinese yam. The preserve Chinese yam has the function of invigorating vital energy, restoring consciousness, invigorating liver, improving eyesight, nourishing essential fluid, and reinforcing kidney.
Several studies have explored the association between fish consumption during pregnancy and favorable neonatal outcomes, although some yield conflicting results. The American College of Obstetricians and Gynecologists recommends two to three servings of low-mercury fish per week for pregnant or breastfeeding women. However, fish can be a source of pollutants, like methylmercury, impacting neurological development. Conflicting studies on docosahexaenoic acid (DHA) supplementation exist in the literature, possibly due to varied supplement dosages. This survey, involving 501 women, investigated fish consumption and DHA supplement intake concerning gestational and neonatal outcomes. Notably, 92.1% of participants consumed fish weekly, with significant differences observed in gestational weight gain, birth weight, and length for those eating fish ≥3 times weekly compared to non-consumers. This study supports the recommendation for pregnant women to include fish in their diet while limiting exposure to environmental pollutants. Omega-3 fatty acid supplements are suggested to attain nutritional benefits without mercury risk.