anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND & AIMS: NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chronic liver diseases. POFUT1 is an essential regulator of NOTCH signaling. Here, we investigated the role of LSEC-expressed POFUT1 in liver fibrosis.
METHODS: Endothelial-specific Pofut1 knockout mice were generated and experimental liver fibrosis was induced by chronic carbon tetrachloride exposure or common bile duct ligation. Liver samples were assessed by ELISA, histology, electron microscopy, immunostaining and RNA in situ hybridization. LSECs and hepatic stellate cells (HSCs) were isolated for gene expression analysis by RNA sequencing, qPCR, and western blotting. Signaling crosstalk between LSECs and HSCs was investigated by treating HSCs with supernatant from LSEC cultures. Liver single-cell RNA sequencing datasets from patients with cirrhosis and healthy individuals were analyzed to evaluate the clinical relevance of gene expression changes observed in mouse studies.
RESULTS: POFUT1 loss promoted injury-induced LSEC capillarization and HSC activation, leading to aggravated liver fibrosis. RNA sequencing analysis revealed that POFUT1 deficiency upregulated fibrinogen expression in LSECs. Consistently, fibrinogen was elevated in LSECs of patients with cirrhosis. HSCs treated with supernatant from LSECs of Pofut1 null mice showed exacerbated activation compared to those treated with supernatant from control LSECs, and this effect was attenuated by knockdown of fibrinogen or by pharmacological inhibition of fibrinogen receptor signaling, altogether suggesting that LSEC-derived fibrinogen induced the activation of HSCs. Mechanistically, POFUT1 loss augmented fibrinogen expression by enhancing NOTCH/HES1/STAT3 signaling.
CONCLUSIONS: Endothelial POFUT1 prevents injury-induced liver fibrosis by repressing the expression of fibrinogen, which functions as a profibrotic paracrine signal to activate HSCs. Therapies targeting the POFUT1/fibrinogen axis offer a promising strategy for the prevention and treatment of fibrotic liver diseases.
IMPACT AND IMPLICATIONS: Paracrine signals produced by liver vasculature play a major role in the development of liver fibrosis, which is a pathological hallmark of most liver diseases. Identifying those paracrine signals is clinically relevant in that they may serve as therapeutic targets. In this study, we discovered that genetic deletion of Pofut1 aggravated experimental liver fibrosis in mouse models. Moreover, fibrinogen was identified as a downstream target repressed by Pofut1 in liver endothelial cells and functioned as a novel paracrine signal that drove liver fibrosis. In addition, fibrinogen was found to be relevant to cirrhosis and may serve as a potential therapeutic target for this devastating human disease.
The present invention relates to a Chinese traditional patent medicine for treating condylomata acuminate, which takes more than 10 Chinese herbal medicines of common burreed rhizome, zedoary, pomegranate rind, oyster etc. as the raw materials. The present invention has the effects of clearing heat, eliminating dampness, removing toxicity and resolving masses. Based on the differential treatment of the traditional Chinese medicine, the invention is developed by combining the latest scientific research results with the traditional Chinese medicine. The present invention aims at providing the Chinese traditional patent medicine to treat condylomata acuminate. The present invention is characterized by accurate efficacy, safety, convenience, no toxicity or side effects and low price.
OBJECTIVE: About 3% of patients with lupus develop severe diffuse alveolar hemorrhage (DAH) with pulmonary vasculitis. C57BL/6 (B6) mice with pristane-induced lupus also develop DAH, but BALB/c mice are resistant. DAH is independent of Toll-like receptor signaling and other inflammatory pathways. This study examined the role of the MEK1/2 pathway (MEK1/2-ERK1/2, JNK, p38).
METHODS: B6 and BALB/c mice were treated with pristane with or without inhibitors of MEK1/2 (trametinib/GSK1120212 [GSK]), ERK1/2 (SCH772984 [SCH]), JNK, or p38. Effects on lung hemorrhage and hemostasis were determined.
RESULTS: GSK and SCH abolished DAH, whereas JNK and p38 inhibitors were ineffective. Apoptotic cells were present in lung samples from pristane-treated mice but not in mice receiving pristane and GSK, and endothelial dysfunction was normalized. Expression of the ERK1/2-regulated transcription factor early growth response 1 increased in pristane-treated B6, but not BALB/c, mice and was normalized by GSK. Pristane also increased expression of the anticoagulant genes Tfpi and Thbd in B6 mice. The ratio of Tfpi to tissue factor (F3) to Tfpi increased in B6 (but not BALB/c) mice and was normalized by GSK. Circulating thrombomodulin protein levels increased in B6 mice and returned to normal after GSK treatment. Consistent with augmented endothelial anticoagulant activity, pristane treatment increased tail bleeding in B6 mice.
CONCLUSION: Pristane treatment promotes lung endothelial injury and DAH in B6 mice by activating the MEK1/2-ERK1/2 pathway and impairing hemostasis. The hereditary factors determining susceptibility to lung injury and bleeding in pristane-induced lupus are relevant to the pathophysiology of life-threatening DAH in systemic lupus erythematosus and may help to optimize therapy.
FIELD: medicine, psychiatry. SUBSTANCE: method involves oral administration of red fly agaric tincture prepared with 40% alcohol solution at ratio of components = 1:50. Preparation is given three times per a day for 3 months. A single dose at the first treatment day - 1 drop of tincture, then dose is increased every day up to 30 drops. The following 2 months tincture is given at dose 30 drops. Method ensures to overcome resistance and enhance therapeutic effectiveness of treatment. EFFECT: enhanced effectiveness of treatment. 3 cl, 1 tbl
Phase 1: Intravenous infusion of 40 mg/m² Taxotere and 40 mg/m² Cisplatin followed by 24 h-infusion of 2000 mg/m² 5-FU on day 1 and day 8 every 3 weeks. If possible an escalation to 50 mg/m² Taxotere and 50 mg/m² Cisplatin can be carried out.
BackgroundSince February 2022, the start of the full-scale war in Ukraine, millions of women and children have fled the country. Vaccination of refugee children is important to protect this vulnerable population from disease.AimWe investigate the determinants of vaccination intention in refugee mothers from Ukraine residing in Poland and test the effect of three message frames.MethodsParticipants were randomised into either a control group or one of three intervention groups encouraging vaccination using a specific frame: (i) trust in the Polish health system, (ii) ease of access to vaccination or (iii) risk aversion. Primary outcomes were intention to vaccinate a child in Poland and clicking on a vaccination scheduling link.ResultsThe study was completed by 1,910 Ukrainian refugee mothers. Compared with the control group, the risk aversion message significantly increased vaccination intention (adjusted odds ratio (AOR): 2.35, 95% confidence interval (CI): 1.25-4.42) and clicking on the vaccine scheduling link (AOR: 1.53, 95% CI: 1.12-2.09). Messages around trust and ease of access did not have an effect. Important determinants of vaccination intention were perceived importance of vaccination (AOR: 1.12 95% CI: 1.01-1.25) and trusting vaccination information official health institutes (AOR: 1.40 95% CI: 1.06-1.83) and social media (AOR: 2.09 95% CI: 1.33-3.27).DiscussionUsing a risk aversion frame highlighting the vulnerability to infection that refugees face resulted in increased vaccination intention and clicks on a vaccination scheduler. Health workers who interact with Ukrainian refugees could use this frame in their vaccination communication.
FIELD: medicine. ^ SUBSTANCE: dosed (medicinal) form of immediate release contains at least one active ingredient, has hard core and coat. Coat surrounds at least part of core. Core has density of about 0.9 g/cm3 and porosity less than 40%. Coat of dosed form contains one or more holes and is easily soluble in gastro-intestinal fluids. ^ EFFECT: dosed form according to the invention ensures immediate release of active ingredient after contact with liquid medium of gastro-intestinal tract, minimises impact of environment on core in oral cavity and increases impact of solving medium on core. ^ 17 cl, 17 dwg, 1 ex
PURPOSE: The primary aim was to compare the prevalence of acute and delayed intracranial haemorrhage (ICH) following mild traumatic brain injury (mTBI) in patients on antithrombotic medication referred to a clinic for oral and plastic maxillofacial surgery. The secondary aim was to evaluate the need for short-term hospitalisation based on initial radiological and clinical findings.
METHODS: This was an observational retrospective single-centre study of all patients on antithrombotic medication who were admitted to our department of oral and plastic maxillofacial surgery with mTBI over a 5 year period. Demographic and anamnesis data, injury characteristics, antithrombotic medication, radiological findings, treatment, and outcome were analysed. Patients were divided into the following four groups based on their antithrombotic medication: (1) single antiplatelet users, (2) vitamin K antagonist users, (3) direct oral anticoagulant users, and (4) double antithrombotic users. All patients underwent an emergency cranial CT (CT0) at admission. Based on clinical and radiological evaluation, different treatment protocols were applied. Patients with positive CT0 findings and patients with secondary neurological deterioration received a control CT (CT1) before discharge. Acute and delayed ICH and patient's outcome during hospitalisation were evaluated using descriptive statistical analysis.
RESULTS: A total of 696 patients (mean age, 71.6 years) on antithrombotic medication who presented at our department with mTBI were included in the analysis. Most injuries were caused by a ground-level fall (76.9%). Thirty-six patients (5.1%) developed an acute traumatic ICH, and 47 intracerebral lesions were detected by radiology-most of these in patients taking acetylsalicylic acid. No association was detected between ICH and antithrombotic medication (p = 0.4353). In total, 258 (37.1%) patients were admitted for 48 h in-hospital observation. The prevalence of delayed ICH was 0.1%, and the mortality rate was 0.1%. Multivariable analysis identified a Glasgow Coma Scale (GCS) of < 15, loss of consciousness, amnesia, headache, dizziness, and nausea as clinical characteristics significantly associated with an increased risk of acute ICH, whereas age, sex, and trauma mechanism were not associated with ICH prevalence. Of the 39 patients who underwent a control CT1, most had a decreasing or at least constant intracranial lesion; in three patients, intracranial bleeding increased but was not clinically relevant.
CONCLUSION: According to our experience, antithrombotic therapy does not increase the rate of ICH after mTBI. A GCS of < 15, loss of consciousness, amnesia, headache, dizziness, and nausea are indicators of higher ICH risk. A second CT scan is more effective in patients with secondary neurological deterioration. Initial CT findings were not clinically relevant and should not indicate in-hospital observation.
The invention discloses a Chinese herbal medicine and a preparation method thereof for treating Riemerella anatipestifer infection, which belongs to the technical field of medicine manufacture for poultry. The medicine is prepared from the following bulk drugs in weight portion: 2 to 5 portions of coptis root, 2 to 5 portions of phellodendron, and 3 to 8 portions of liquorice. In order to obtain better effect, the medicine can also combine with 2 to 5 portions of atractlylis lancea formalyrata and 2 to 5 portions of cortex moutan. After the drugs are decocted or active ingredients of the drugs are extracted by hydro-alcohol, the drugs can be prepared into powdered medicine or injection respectively, so that prevention or treatment can be carried out on pathogenetic duck group through mixing the powdered medicine with feed or water, or through injection. An experiment is carried out with drug concentration of 0.03g/ml, wherein illness condition in a treatment group can be controlled after three days, the mortality rate is reduced to 36 percent compared with 73 percent; and the mortality rate of a prevention group is reduced to between 1.3 and 2.8 percent compared with 13 percent, and the prevention group has prominent effect, and has equivalent cure rate to a bacteriophage treatment group. The Chinese herbal medicine and the preparation method have the characteristics of low cost, convenient application, prominent effect and the like, and can be popularized and applied in the duck breeding industry.
The underlying mechanisms of atherosclerosis, the second leading cause of death among Werner syndrome (WS) patients, are not fully understood. Here, we establish an in vitro co-culture system using macrophages (iMφs), vascular endothelial cells (iVECs), and vascular smooth muscle cells (iVSMCs) derived from induced pluripotent stem cells. In co-culture, WS-iMφs induces endothelial dysfunction in WS-iVECs and characteristics of the synthetic phenotype in WS-iVSMCs. Transcriptomics and open chromatin analysis reveal accelerated activation of type I interferon signaling and reduced chromatin accessibility of several transcriptional binding sites required for cellular homeostasis in WS-iMφs. Furthermore, the H3K9me3 levels show an inverse correlation with retrotransposable elements, and retrotransposable element-derived double-stranded RNA activates the DExH-box helicase 58 (DHX58)-dependent cytoplasmic RNA sensing pathway in WS-iMφs. Conversely, silencing type I interferon signaling in WS-iMφs rescues cell proliferation and suppresses cellular senescence and inflammation. These findings suggest that Mφ-specific inhibition of type I interferon signaling could be targeted to treat atherosclerosis in WS patients.
Patients attending consultation for LASIK on Day 1. No intervention or treatment is administered during the study.
Methods and compositions for blocking various channels and receptors within an organism are provided. For example, two toxins were isolated from the Agelenopsis aperta spider. The first toxin comprised a toxin having a molecular weight of from approximately 5,000 to approximately 10,000. This toxin was found to have an irreversible effect on calcium channels within the central nervous system. A second toxin having a molecular weight of less than about 1,000 was also isolated. This toxin was found to have a reversible blocking effect on calcium channels within the central nervous system and the cardiovascular system. 
     A third toxin was isolated from the Argiope aurantia spider. This toxin was found to have a reversible effect on excitatory amino acid receptors. Finally, a toxin having a molecular weight of from approximately 5,000 to approximately 7,000 daltons was isolated from the Hololena Curta spider. This toxin was found to have an irreversible effect on excitatory amino acid receptors. 
     The present invention further relates to methods of treating heart and neurological diseases by applying the toxins isolated and identified. In particular, the low molecular weight toxin from Agelenopsis aperta may provide a treatment of certain heart conditions such as arrhythmia, angina, Hypertension, and congestive heart failure. In addition, the toxins may provide beneficial effects on certain neurological conditions including seizures. It is also found that the toxins having an irreversible effect are effective as tags in probing the various components within the calcium channels and excitatory amino acid receptors and are effective insecticides and anthelmintics.
The invention discloses a preservative-free herbal composition with a corrosion-resistant effect, and prepared from plant extracts and a humectant, and the application of the preservative-free herbal composition in daily cosmetics. The formula of the preservative-free herbal composition comprises the followings: 0.5 percent of lotuses, 0.5 percent of radix sophorae flavescentis, 0.3 percent of purslane, 0.1 percent of honeysuckle, 0.1 percent of mugwort leaves, 0.1 percent of wild chrysanthemum flowers, 0.1 percent of tree peony barks, 0.1 percent of dandelion, 0.1 percent of cortex phellodendri, 0.5 percent of 1,2- hexanediol, 0.5 percent of p-Hydroxyacetophenone, and the balance of water. Compared with the prior art, the preservative-free herbal composition provided by the invention has the benefits as follows: the reliability is high, the stability is excellent, a mild effect to human bodies can be played, the construction cost is low, and the corrosion-resistant effect is obvious. Preservatives added in cosmetics are replaced, the mildew and rot resisting capability of the cosmetics is not changed obviously, and chemical preservatives are not added in the cosmetics. The irritation risk of cosmetics is lowered, and the safety of cosmetics is improved. The preservative-free herbal composition provided by the invention adopts the herbal preservative-free technology which means that raw materials used are herbal extractives. The mildew and rot resisting capability of the composition is superior to that of a single component, the prescription is more scientific and efficient, and the mildew and rot resisting capability is more superior.
The invention discloses a medicine cefetamet pivoxil hydrochloride composition for treating infectious diseases, and belongs to the technical field of medicine. The composite is composed of cefetamet pivoxil hydrochloride and anhydrous sodium carbonate. Cefetamet pivoxil hydrochloride is crystals. An X-ray powder diffraction pattern measured through Cu-K alpha rays is shown in figure 1. The new crystal form of cefetamet pivoxil hydrochloride is different from a crystal form structure in the prior art. It is surprisingly found through test verification that compared with the prior art, a powder injection prepared from the new crystal form compound is high in mobility, has the low high-molecular polymer content and is high in stability, and the content of high-molecular polymers is slowly increased while the storage time is prolonged; meanwhile, the compound has more obvious antibacterial activity for pneumococcus and hemophilus influenzae, and has high antibacterial activity for enterococcus and staphylococcus as well.
Subjects will attend two weekly 120-minute of self-administered acupressure training according to the group allocation in a classroom at the School Nursing, the Hong Kong Polytechnic University. The subjects will be trained to perform self-administered acupressure by an acupuncturist. To enhance interaction and ensure the quality of teaching, each class will be conducted in a small group of 5 to 7 subjects. Participants in this group will learn the self-acupressure technique and passed fidelity check. The treatment protocol included 6 acupoints, namely, Baihui (GV20) and bilateral Fenchi (GB20), Neiguan (PC6), Shenmen (HT7), Shenxu (BL23) and Yongquan (KI1) (Table 1). Subjects were given an acupressure log to record their practice at home, and they were phoned twice a week to remind their practice during the 4-week treatment period.
During Stage 1 of Part 1, participants will be randomized to receive daratumumab treatment regimens in Group A and Group B. If in Stage 1, 1 or both of the treatment groups is considered to be ineffective and/or not well tolerated, then that treatment group will be terminated. Participants in Group B will be given the option to cross over to Group A if the investigator deems it in the best interest of the participants.
This group will not receive Vielight RX Plus treatment. Instead, they will follow the COVID-19 standard of treatment recommended by Health Canada.
Family Based Treatment Guided Self-Help (FBT-GSH) includes an online website with educational videos, readings, discussion groups, and journals. Parents assigned to this arm will have up to 12 coaching sessions (20-30 minutes) with a trained therapist.
The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti- body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex- pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi- nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal- ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam- ple of a subject. Still further, the present invention relates to a method of treating a sample, e.g. an immunoaffinity-based sample preparation method for enrich- ment of the halogenated bisphenol A from a sample.
A semi-standardized form of Traditional Chinese Acupuncture (TCA) is administered, incorporating the insertion of up to 22 acupuncture needles associated with each individual participant's: (1) primary headache pattern (up to three pairs of points); (2) secondary headache pattern (up to 2 pairs of points); (3) Ah-Shi or tender points (up to 4 points); (4) constitutional points (source points on two meridians); and, (5) up to 2 pairs of additional points from a selected list. Point selection was reassessed every two weeks per TCM diagnostic and treatment principles. While the majority of points were located on the limbs, points also included local points of tenderness to the head, as well as the front and back of the torso. Ten 60-minute TCA sessions are administered over 6 weeks.
PROBLEM TO BE SOLVED: To obtain the subject safe agent excellent in effects, comprising lactulose as an active ingredient. SOLUTION: This agent comprises lactulose as an active ingredient. Lactulose is obtained, for example, by a method for adding an acid or a milk-clotting enzyme to a lactose solution, a mammalian milk or a skimmed milk, removing a formed coagulum from the solution and adding an alkali agent such as calcium hydroxide to the residual aqueous solution. A cow's milk is preferable as the mammalian milk. Economically, a skimmed milk or whey is used as the raw material. Lactulose on the market is conveniently used. The objective agent is administered, for example, in a dose of 1-6,000mg/kg weight daily dividedly twice to three times. When the agent is added to a feed and is applied to fishes in a juvenile stage, preventive effects are obtained. In this case, the amount of lactulose is preferably 0.01-5wt.%.  The objective agent is applicable, for example, to an infectious disease of Rod shaped virus Penaeus japonicus of prawn.
PROBLEM TO BE SOLVED: To obtain a therapeutic agent for condyloma acuminatum derived from human papillomavirus, excellent in safety, capable of providing treating effects by a simply method, comprising a natural substance contained in tea drunk in daily life as a main component. SOLUTION: This therapeutic agent comprises a tea catechin of formula I (R<1> is H or OH; R<2> is H or a group of formula II). (-)-Epicatechin gallate is preferable among tea catechins. The therapeutic agent can be used in the form of embrocation in creamy, jelly or milky liquid state and suppository in a capsulated state. Peptone is preferable as a base in the embrocation. The amount of the tea catechin formulated is 5-20wt.% and that of peptone is 5-20wt.% in the case of the embrocation and the amount of the tea catechin formulated is 100-500mg/capsule in the case of the suppository.