anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The s afe ty and e f fi c a cy of lamivudine tablets (HBV) w ere ev alu at ed in a doubl e-blind clini cal t ri al in 286 subj ects a g ed f rom 2 to 17 y e ars, who w ere r andomi z ed (2:1) to recei ve 52 weeks of lamivudine tablets (HBV) (3 mg p er kg on ce d ai ly to a m a ximum of 100 mg on ce d ai l y) or pl a c ebo. All subj ects h ad comp ens a t ed ch ronic h e p atitis B a ccomp ani ed by evid en ce of h ep atitis B vi rus repli cation (positive s er um H B e Ag and positive for s erum H BV D NA by a res e arch b ran ch e d -c h ain DNA as s a y) and p e rsist ent ly el ev at ed s erum A LT l e v els. The combin ation of loss of H B e Ag and r edu ction of H BV D NA to b e low the ass ay limit of the res e a rch as s a y, ev alu at ed at W eek 52, w as obs erv ed in 23% of s ubj ects t reat ed with lamivudine tablets (HBV) and 1 3% of pl acebo -t r eat ed subj e cts. No rm ali z ation of s erum A LT was a chi ev ed and m aint ain ed to W eek 52 mo re freq u ent ly in subj e cts t reat ed with lamivudine tablets (HBV) comp ared with pl acebo (55% v ersus 13 %). As in the adult co nt roll ed t ri als, most subj ects t reat ed with lamivudine tablets (HBV) h ad d e c rea s es in H BV D NA b elow the as s ay limit ear ly in t r e atm e nt, but about on e-thi rd of subj ects with this initi al response h ad r e a pp eara n ce of ass a y - d et ec t able H BV DNA du ri ng t re atm ent. Adol es cents ( a g ed 13 to 17 y e ars) sh o wed l ess evid e n ce of t r e atm ent eff e ct th an you n g er p edi at ric subj e cts.
This will be prospective randomized (1:1) open label pilot study. Patients with unstable angina and non-ST-elevation ACS and history of AF will be included in this study. After PCI and DES implantation TEE will be performed for assessing LAA anatomy and size eligible for left atrial appendage closure device implantation. After screening all patients will be randomized in two groups. The first (control) group will receive standard antiplatelet and anticoagulation therapy according to the guidelines (2), the second group of patients will undergo left atrial appendage closure device implantation. After the PCI the first group will take Triple therapy (warfarin + clopidogrel+aspirin) during 45 days and after combination of warfarin+clopidogrel to 6 months after procedure and then only warfarin. The second group will take Triple therapy (warfarin+clopidogrel+aspirin) during 45 days following PCI and after control TEE, warfarin will be discontinued. Then patients from the second group will take DAPT combination (clopidogrel+aspirin) to 6 months after procedure and then only aspirin. Patients will be followed at 45 day, and every 3 months during 12 months of follow up (Figure 1). At each follow-up visits the data regarding clinical events and healthcare utilization will be collected.
Method of selectively damaging mammalian sperm of differing volume within an ejaculate. In order to utilise the physical difference in volume between X and Y sperm for influencing the sex, it has hitherto been conventional to use sedimentation and centrifugation methods. However, these methods are too crude for utilising the very small difference in volume between X and Y sperm. The novel method is much more sensitive to the difference in size, and it makes it possible to allow only large sperm or only small sperm to participate in the process of fertilisation. Warble sound frequencies which must be individually adapted to the sperm of the animal achieve a high selectivity as regards the volume. The method forms the basis for influencing the sex in mammals due to differences in the size of X and Y sperm.
BACKGROUND: The exact mechanisms linking the gut microbiota and social behavior are still under investigation. We aimed to explore the role of the gut microbiota in shaping social behavior deficits using selectively bred mice possessing dominant (Dom) or submissive (Sub) behavior features. Sub mice exhibit asocial, depressive- and anxiety-like behaviors, as well as systemic inflammation, all of which are shaped by their impaired gut microbiota composition.
METHODS: An age-dependent comparative analysis of the gut microbiota composition of Dom and Sub mice was performed using 16S rRNA sequencing, from early infancy to adulthood. Dom and Sub gastrointestinal (GI) tract anatomy, function, and immune profiling analyses were performed using histology, RT-PCR, flow cytometry, cytokine array, and dextran-FITC permeability assays. Short chain fatty acids (SCFA) levels in the colons of Dom and Sub mice were quantified using targeted metabolomics. To support our findings, adult Sub mice were orally treated with hyaluronic acid (HA) (30 mg/kg) or with the non-steroidal anti-inflammatory agent celecoxib (16 mg/kg).
RESULTS: We demonstrate that from early infancy the Sub mouse gut microbiota lacks essential bacteria for immune maturation, including Lactobacillus and Bifidobacterium genera. Furthermore, from birth, Sub mice possess a thicker colon mucin layer, and from early adulthood, they exhibit shorter colonic length, altered colon integrity with increased gut permeability, reduced SCFA levels and decreased regulatory T-cells, compared to Dom mice. Therapeutic intervention in adult Sub mice treated with HA, celecoxib, or both agents, rescued Sub mice phenotypes. HA treatment reduced Sub mouse gut permeability, increased colon length, and improved mouse social behavior deficits. Treatment with celecoxib increased sociability, reduced depressive- and anxiety-like behaviors, and increased colon length, and a combined treatment resulted in similar effects as celecoxib administered as a single agent.
CONCLUSIONS: Overall, our data suggest that treating colon inflammation and decreasing gut permeability can restore gut physiology and prevent social deficits later in life. These findings provide critical insights into the importance of early life gut microbiota in shaping gut immunity, functionality, and social behavior, and may be beneficial for the development of future therapeutic strategies.
Participants received SCIT titrated up to a 4000 bioequivalent allergy unit (BAU) for 8 weeks followed by maintenance dose of 4000 BAU for following 8 weeks and SC injections of placebo matched to Dupilumab Q2W for 16 weeks. Both SCIT and placebo matched to Dupilumab doses were administered with a gap of 1 or 7 days.
At the conclusion of the surgery, a 0.2 mL/kg bolus of Saline will be injected through each catheter in the OR. At midnight following the OR, 0.2mL/Kg of Saline will be injected through each catheter every 8 hours for the next 2 postoperative days by a MD member of the pain team. At 8am on postoperative day 3, the TAP catheters were removed by the pain team. Our rationale for decreasing the frequency of intermittent boluses from every 12 hours to 8 hours in this study design was based on our finding in the pilot study that patients frequently used more PCA between 8-12 hours following Bupivacaine bolus as the effect of the anaesthetic agent weaned off.
Background and Objectives: This observational study investigates the relationship between Lipoprotein (a) (Lp(a)) levels and the risk of acute myocardial infarction (AMI). This study aims to highlight the association of elevated Lipoprotein (a) levels with an increased atherogenic profile and the potential risk of AMI. Materials and Methods: We conducted a case-control study involving 106 individuals, including 64 AMI patients (both STEMI and NSTEMI) and 42 healthy controls. Comprehensive clinical and biochemical assessments, including Lp(a) measurements, were conducted. Results: Patients with Lp(a) levels ≥ 30 mg/dL had a threefold increased risk of AMI compared to those with lower levels, independent of traditional risk factors such as cholesterol, smoking, and body weight. Elevated Lp(a) was observed in 50% of AMI patients compared to 28.57% in controls (p = 0.028). Notably, a multivariate analysis identified high Lp(a) levels, low HDL-C levels, and obesity as significant independent predictors of AMI, indicating these factors may contribute to AMI risk more prominently than other conventional risk factors in patients with elevated Lp(a). Moreover, the association between Lp(a) and AMI risk was consistent across various patient subgroups, with low HDL-C further compounding the risk. Conclusions: Lp(a) is a significant independent risk factor for acute myocardial infarction; therefore, screening for Lp(a) levels can help identify high-risk individuals beyond traditional markers. Therapeutic approaches targeting Lp(a) may reduce AMI incidence. Future research should explore how Lp(a) promotes atherosclerosis and assess Lp(a)-lowering therapies to improve patient outcomes.
A randomised, double-blind, placebo-controlled, parallel-design study assessing the effect of a 4-week intervention of lemon balm extract (or matched placebo) in young to middle-age adults with mild sleep problems. A total of 108 participants will be randomly assigned to either 300 mg lemon balm extract or a matched placebo capsule consumed nightly before retiring to bed. The severity of sleep problems, depression, anxiety, perceived stress, quality of life and well-being will be measured at baseline and after 4 weeks of daily consumption. In addition, we will assess changes in microbiota and saliva neurohormone profiles at baseline and after 4 weeks of treatment.

Entry to the study to determine eligibility involves a sleep quality questionnaire (PSQI) score of 5 and above. The study comprises of a familiarisation visit and then two test days at the Nutritional Psychology Unit based at the University of Reading where primary sleep (PSQI), and exploratory measures of sleep (ISI, LSEQ) and mood (PANAS, Vivascentz(TM), FFS, PSS, DASS-21) tests will be completed. The screening visit will further assess habitual diet (Epic-Norfolk FFQ), and general health and lifestyle patterns to confirm eligibility. Participants will then continuously wear an wrist-secured actiwatch whilst recording a daily sleep diary to estimate sleep changes over the 4-week period. In addition, some further exploratory tests will be completed by participants from home 24h before baseline and 24h before post-intervention (saliva, stool, PANAS-X).
BACKGROUND: Exercise therapy can effectively manage chronic kidney disease (CKD) risk factors and improve renal function and physical fitness, but the challenge lies in choosing the right exercise type tailored to patients' condition.
METHODS: An electronic search of databases including PubMed, The Cochrane Library, EMBASE, Web of Science, VIP, WanFang, and CNKI was performed. The random effects model was used. Mean difference was employed as the effect size for continuous variables, with 95% confidence interval (CI) provided.
RESULTS: A total of 36 RCTs were included in this study. Compared to conventional therapy (CT), the combination of three exercise therapies with CT resulted in notable benefits in enhancing six minutes walk test (6MWT) capacity, 24-h urinary protein quantity (24hUTP), systolic blood pressure (SBP), diastolic blood pressure (DBP). Resistance exercise therapy (RT) + CT were more effective than CT to reduce serum creatinine (Scr), body mass index (BMI), and hemoglobin A1c (HbA1c) and improve estimated glomerular filtration rate (eGFR). In terms of improving peak oxygen uptake (VO2 peak), only two exercise modalities were involved, aerobic exercise therapy (AT) and combined (Resistance-Aerobic) exercise therapy (CBT), both of which were more efficacious than CT. The efficacy ranking overall demonstrated clear benefits for RT in enhancing eGFR and 6MWT, decreasing Scr, BMI, SBP, DBP, and HbA1c, while AT was more suitable for boosting VO2 peak, and CBT had greater potential for reducing 24hUTP.
CONSLUSIONS: Exercise therapy combined with CT offers significant advantages over CT in many cases, but no single exercise modality is universally effective for all indicators.
Intervention Group: 8-day intensive treatment where each treatment day consists of the following schedule: Physical activity: 30 minutes Prolonged Exposure (PE): 90 minutes Physical activity: 30 minutes Lunch Physical activity: 60 minutes Eye Movement Desensitization and Reprocessing (EMDR): 90 minutes Physical activity: 30 minutes (omitted on days 4 and 8) Dinner Psychoeducation (omitted on days 4 and 8) Participants stay at the SÄS patient hotel during the treatment (with a three-day weekend break between treatment days 1-4 and 5-8). The treatment concept includes therapist rotation, meaning that participants switch therapists between PE and EMDR sessions. The purpose of this is to increase focus on the processing process rather than the relationship between the therapist and the client.
PURPOSE:The titled pharmaceutical containing a pymphotoxin obtained by transplanting a cell derived from a man, having the ability to produce the lymphotoxin and cultivated into a strain to a warm-blooded animal other than the man, multiplying the cell, and reacting a lymphotoxin iunducer with the resultant cell. CONSTITUTION:A cell, having the ability to produce lymphotoxin and cultivated into a strain, and derived from a man is transplanted to a warm-blooded animal other than the man, e.g. an egg, embryo or fetus as juvenile as possible, of a bird such as domestic fowl or mammal such as a dog or cat, and multiplied  while supplied with the body fluid of the warm-blooded animal to give a cell,  which is then reacted with a lymphotoxin inducer and purified to afford a lymphotoxin. The resultant lymphotoxin is then subjected to the affinity chromatography with phytohemagglutinin- ''Sepharose  '', etc. and purified to give the  lymphotoxin easily and rapidly in high purity. A preventing agent and remedy  for lymphotoxin-sensitive diseases very safe in side effects is obtained from the  resultant lymphotoxin.
PURPOSE:To provide a harmless and safe anti-inflammatory agent containing a sulfatide as an active component and useful for the treatment of inflammatory diseases such as hepatitis and chronic nephritis. CONSTITUTION:This ainti-inflammatory agent contains a sulfatide of formula (R-CO is a fatty acid residue), i.e., cerebroside sulfate as an active component. The daily dose of the sulfatide for adult is 0.1-1g for oral administration, 10-100mg for intravenous injection, 50-300mg for intramuscular injection and 30-150mg for subcutaneous or intradermic injection. The concentration of the sulfatide in an external agent is usually 0.1-1%(W/W). The sulfatide can be produced e.g. by extracting bovine cerebral cinerea with chloroform/methanol, etc., and purifying the extract by Folchs partition method and a Q-Sepharose column.
Analgesic medicaments contain short chain fatty acids and/or hydroxylated fatty acids and/or ketonic fatty acids or esters of these cpds. Typical esters are butyric acid esters, such as glycerine tributyrate), beta-hydroxy-butyric acid esters and acetyl acetic acid esters. The medicaments are well tolerated and have no serious side effects. The esters are osmotically inactive and are particularly useful for intravascular injection. Clinical tests are described in which pain is relieved in cancer patients. Doses are 200-1000 mg per day. Difficultly soluble esters may be formulated with emulsifiers, such as lecithin or mixed triglycerides.
Included patients were aged more than or equal to 18 years, and were required to have a diagnosis of melanoma (ICD-9 172.x \& ICD-10 C43 or D03x), a pathologic stage IV diagnosis, treatment with IO (e.g. ipi, nivo, pembro, ipi+nivo) or TT (dab+tram, vem+cobi, enco+bini) on or after January 1, 2014 and prior to May 31, 2020 (data cut-off), and evidence of a BRAF+ result after therapy initiation. Patients were required to be classified as LTB at the time of stage IV diagnosis. LTB was defined as having normal LDH and \<3 metastatic sites at the time of stage IV diagnosis.
An agent for suppressing blood pressure elevation of the present invention comprises a soluble silicon compound. As the soluble silicon compound, metasilicic acid or a salt thereof is preferred. Another embodiment of the agent for suppressing blood pressure elevation of the present invention comprises deep ocean water containing a soluble silicon compound or a dried matter thereof. In this embodiment, it preferably further comprises metasilicic acid or a salt thereof. Here, the content of silicate silicon (SiO2-Si) in the deep ocean water is preferably 25 µM or more. The deep ocean water is deep sea water at a depth of 300 m or below, preferably 600 m or below.
The techniques described herein relate to computerized methods and apparatus for determining when a medication delivery device is ready for use. The method includes obtaining, from a temperature sensor of a medication delivery device, temperature data indicative of a temperature. The method includes obtaining, from an ambient light sensor, ambient light data indicative of an amount of ambient light to which at least a portion of the medication delivery device is exposed. The method includes determining, based on the temperature data, whether the temperature exceeds a temperature threshold. The method includes determining, based on the ambient light data, whether the amount of light exceeds an ambient light threshold. The method includes outputting an indication that the medication delivery device is ready for use when the temperature exceeds the temperature threshold and the amount of ambient light exceeds the ambient light threshold.
Radiation-induced enteritis is an common and severe side effect of the patients undergoing pelvic radiotherapy. It can lead to dose-limiting and debilitating treatment effect. There is no guideline on an acknowledged intervention that significantly reduces its severity. In previous study, we have abserved that a probiotic combination significantly enhances the immune response of patients and reduces the severity of oral mucositis through modification of gut microbiota. In this stuyd we plan to designe a randomized trial of Probiotics probiotics in patients with pelvic carcinoma.The aim of this study is to determine if regulating intestinal tract flora will reduce the severity of radiation-induced mucositis in patients receiving pelvic radiotherapy. The effect of this intervention on a patient's general well-being was also investigated. The primary end-point of the study was the incidence of grade 3 enteritis. In 2021, 40 patients are estimated to be recruited into the study in Jiangxi Cancer Hospitals, China. 20 patients were randomized to receive Probiotics or placebo during chemoradiotherapy respectively.
FIELD: medicine, oncology, phytotherapy. SUBSTANCE: agent to be claimed has the following components: knotgrass (knotweed) herb, dioecious nettle herb, field horse-tail herb, marsh-mallow roots, barberry roots, mugwort herb, quinqueloble motherwort herb, swampy sweet flag roots, peppermint leaves, valerian roots. By contrast with prototype, the proposed agent has the following component additionally: lungwort herb, creeping wheat-grass roots, field penny-cress seeds, Polish mushroom, shilagit, bear bile, French honey-suckle roots, common caraway seeds, linden flowers, cowberry leaves, medicinal vervain herb, lop-sided Orthilia herb, common goutweed herb, common anise seeds, pink periwinkle herb, cinquefoil (all plant), medicinal garden angelica roots, common toadflax herb, swampy marsh cinquefoil roots, Echinopanax elatum roots, birch buds, common hops cones, medicinal wood betony herb, Orthosiphon stamineus herb, Japanese pagoda-tree flowers, major celandine herb, spring primrose flowers, glaucescent blackberry bush leaves and roots, large-leaves schin-leaf leaves, common agrimony herb, swampy grass-of-Parnassus herb, erianthous milk vetch herb, vegetable dill seeds, ephedra herb and glabrous licorice roots taken in the definite ratio. Composition shows effect on all body, it has clearly expressed alkaline medium of vegetable origin, pH = 7.35-7.5, that corresponds maximally to health humans blood acidity. Composition is assimilated by body cells easily owing to bioavailability, it does not show adverse symptoms that ensures to use its for a long time. The agent recoveries metabolism, stimulates immune system, neutralizes effect of free radicals in body and provides the stable therapeutic effect due to power antioxidant activity. Invention can be used for prophylaxis and treatment of any tumors. EFFECT: valuable medicinal properties of agent, enhanced effectiveness. 1 cl, 5 ex
Participants will receive ABBV-916 Dose A for 24 weeks. Participants at the end of 24 weeks will have the option of participating in the 2-year Extension Period.
All multiple myeloma cell lines examined showed constitutively active IkB kinase (IKK), IkBα phosphorylation and constitutively active NF-kB. Curcumin, a chemopreventive agent, suppressed constitutive IkBα phosphorylation through inhibition of IKK activity and downregulated NF-kB. Curcumin also downregulated expression of NF-kB-regulated gene products such as IkBα, Bcl-2, Bcl-xL, cyclin D1 and interleukin-6. Consequently, curcumin suppressed multiple myelona cell proliferation and arrested cells at the G1/S phase of the cell cycle. Curcumin also induced apoptosis and chemosensitivity to vincristine. Overall, results presented herein provide a molecular basis for the treatment of multiple myelona patients with this pharmacologically safe agent.
Physical dependence has been reported with prolonged use of ketamine. Physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or significant dosage reduction of a drug. Withdrawal symptoms have been reported after the discontinuation of frequently used (more than weekly), large doses of ketamine for long periods of time. Reported symptoms of withdrawal associated with daily intake of large doses of ketamine include craving, fatigue, poor appetite, and anxiety.  
  
Tolerance has been reported with prolonged use of ketamine. Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose).
This article aims to present the overview of the situation during the coronavirus disease 2019 (COVID-19) pandemic about issues concerning the prevalence of mental disorders such as depression, anxiety, rate of suicide attempts, and long COVID (LC) infections in the general population during COVID-19 pandemic. Analysis of the literature (in English, Polish and Spanish language) on topics related to COVID-19, mental disorders (suicide attempts, depression, anxiety) and LC infection published during the 4 years (2020-2023) was done using Pubmed and PubMed Central search engine. Keywords such as "COVID-19," "mental disorders," "long COVID infection," "depression," "anxiety," "suicide attempts" were used during the search. The conduct of this review/comment followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) protocol, which corresponds to a checklist of 27 items designed to facilitate the development and reporting of a robust protocol for systematic reviews or meta-analyses. Overall 35 studies were selected and analyzed in the review on topics: including among others LC (14 studies), suicide attempts (7 studies), mental disorders (depression, anxiety) (14 studies). The main issues raised in the articles were: higher risk of LC symptoms in women, fatigue and brain fog listed as frequently encountered patient's complaints together with anxiety, depression, loneliness, especially in younger age groups and in women. Issues regarding LC, mental disorders and suicide attempts requires further research as the results vary in different countries. Int J Occup Med Environ Health. 2024;37(3):360-80.