anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A method for protecting a threaded metal joint from galling and corrosion includes providing a nanocrystalline coating on the metal surface. The nanocrystalline coating can include a solid or liquid lubricant to protect against wear. Threaded metal joint surfaces coated with the nanocrystalline coating can resist galling under high pressure and high torque, even after several fastening and unfastening operations and also over a long period of time. Protection from corrosion is also provided by the nanocrystalline coating. The method and nanocrystalline coating provide metal surfaces with both lubrication and protection against corrosion. Problems such as removal or leakage, which are associated with protective compounds that use oils, are avoided. The nanocrystalline coatings may be layers of the same material, or layers of differeing materials, such as layers with lubricating particles dispersed throughout, and layers without lubricating particles. Such coatings may provide reduced wear, friction, corrosion and galling. Such coated threaded articles are very useful in messy and dirty environments, such as oil production and oil handling industries.
A method of purifying saponin is described. A crude extract of panax notoginseng is provided, wherein the crude extract of panax notoginseng includes a weak retention component, a middle retention component and a strong retention component. The middle retention component includes Notoginsenoside R1, Ginsenoside Re and Ginsenoside Rg1. The strong retention component includes Ginsenoside Rb1 and Ginsenoside Rd. Next, simulated moving bed chromatography was used to separate the middle retention component and the strong retention component saponin from the crude extract of panax notoginseng. By using the simulated moving bed chromatography, the weak retention component, the middle retention component including Notoginsenoside R1, Ginsesenoside Re and Ginsenoside Rg1 may be separated from the strong retention component including Ginsenoside Rb1 and Ginsenoside Rd in the crude extract of panax notoginseng, hence forming saponin with high purity.
The study group for this research consists of 45 oncology nurses who are actively involved in the care and management of patients with implanted Port-A-Catheters for chemotherapy. These nurses are recruited from the Oncology and Nuclear Medicine Center at Kasr Elini hospital, which includes outpatient clinics. The nurses in this study play a critical role in handling long-term venous access devices, particularly Port-A-Catheters, which are essential for the administration of chemotherapy and other related treatments.
Patients will receive intrathecal bupivacaine plus morphine without Pericapsular Nerve Group block. Intrathecal drugs will be administered at the L3-L4 intervertebral level by adding 10-15 mg bupivacaine with 100 μg of morphine.
JTX-8064 in combination with pimivalimab. Cohort will enroll subjects with biliary tract cancer (BTC), including intra-and extra-hepatic biliary duct cancer and cancer of the gallbladder. All subjects must have progressed on or after gemcitabine/cisplatin (Gem/Cis) in the metastatic setting, must have PD-(L)1i resistance.
A system for implementing a rehabilitative physiotherapy program in post stroke period is provided. The system includes a wearable device worn by a subject, configured for monitoring motor activity of the subject. The system also includes a central server configured for storing a plurality of rehabilitative physiotherapy programs to be performed by the subject. The central server is also configured for receiving an instruction from at least one other user for enabling the rehabilitative physiotherapy program to the subject. The central server is configured for receiving motor activity data from the wearable device, after exercising the enabled rehabilitative physiotherapy program by the subject. The central server is configured for analyzing the motor activity data, and communicating a recovery status to the subject and the at least one other user periodically.
Serratia marcescens is an opportunistic pathogen historically associated with sudden outbreaks in intensive care units (ICUs) and the spread of carbapenem-resistant genes. However, the ecology of S. marcescens populations in the hospital ecosystem remains largely unknown. We combined epidemiological information of 1,432 Serratia spp. isolates collected from sinks of a large ICU that underwent demographic and operational changes (2019-2021) and 99 non-redundant outbreak/non-outbreak isolates from the same hospital (2003-2019) with 165 genomic data. These genomes were grouped into clades (1-4) and subclades (A and B) associated with distinct species: Serratia nematodiphila (1A), S. marcescens (1B), Serratia bockelmannii (2A), Serratia ureilytica (2B), S. marcescens/Serratia nevei (3), and S. nevei (4A and 4B). They may be classified into an S. marcescens complex (SMC) due to the similarity between/within subclades (average nucleotide identity >95%-98%), with clades 3 and 4 predominating in our study and publicly available databases. Chromosomal AmpC β-lactamase with unusual basal-like expression and prodigiosin-lacking species contrasted classical features of Serratia. We found persistent and coexisting clones in sinks of subclades 4A (ST92 and ST490) and 4B (ST424), clonally related to outbreak isolates carrying blaVIM-1 or blaOXA-48 on prevalent IncL/pB77-CPsm plasmids from our hospital since 2017. The distribution of SMC populations in ICU sinks and patients reflects how Serratia species acquire, maintain, and enable plasmid evolution in both "source" (permanent, sinks) and "sink" (transient, patients) hospital patches. The results contribute to understanding how water sinks serve as reservoirs of Enterobacterales clones and plasmids that enable the persistence of carbapenemase genes in healthcare settings, potentially leading to outbreaks and/or hospital-acquired infections.IMPORTANCEThe "hospital environment," including sinks and surfaces, is increasingly recognized as a reservoir for bacterial species, clones, and plasmids of high epidemiological concern. Available studies on Serratia epidemiology have focused mainly on outbreaks of multidrug-resistant species, overlooking local longitudinal analyses necessary for understanding the dynamics of opportunistic pathogens and antibiotic-resistant genes within the hospital setting. This long-term genomic comparative analysis of Serratia isolated from the ICU environment with isolates causing nosocomial infections and/or outbreaks within the same hospital revealed the coexistence and persistence of Serratia populations in water reservoirs. Moreover, predominant sink strains may acquire highly conserved and widely distributed plasmids carrying carbapenemase genes, such as the prevalent IncL-pB77-CPsm (pOXA48), persisting in ICU sinks for years. The work highlights the relevance of ICU environmental reservoirs in the endemicity of certain opportunistic pathogens and resistance mechanisms mainly confined to hospitals.
To neutralize the effect of extra attention from the facilitator, participants in control group will receive routine health education on topics related to type 2 diabetes. Contents for the routine education will be based on the national guideline of basic public health service for diabetes and specific implementation protocols in each community. Participants in control group will receive 5-weekly education packet at the same time with participants in intervention group. The patients will not be given any strengths-based information, but they are free to discuss their disease status with nurses or physicians at their regular follow-up appointments.
The present invention relates to a method for the synthesis of compounds useful in the preparation of antibody drug conjugates (ADC), namely, monoprotected dimeric bifunctional prodrugs based on duocarmycin analogs. In a further aspect, compounds obtained by the method according to the present invention are provided. The monoprotected bifunctional prodrug is used for preparing antibody drug conjugates composed of an antibody moiety and the monoprotected bifunctional prodrug. The antibody compound conjugates thus obtained are provided. Further, a method of preparing an antibody drug conjugate composed of two identical or two different antibody moieties is provided as well as the antibody compound conjugate containing two different antibody moieties accordingly. These conjugates can be used in pharmaceutical compositions, in particular, for use in treatment of tumors, e.g. for use in ADC therapy.
PURPOSE:To provide a new high-safety glucosyltransferase inhibitor capable of inhibiting formation of sordes on a tooth and of preventing dental caries or periodontal diseases and useful for a dental composition or a food. CONSTITUTION:There is provided a glucosyltransferase inhibitor containing an extract of Rosa odorata Sw. var. ihea Makino and/or a sweet brier. A solvent extract is preferably used as the abovementioned extract and one or more kinds of solvents selected from chloroform, methanol, ethanol, propylene glycol and 1,3-butylene glycol are used as the extracting solvent. This inhibitor component is used suitably in an amount of 0.001 to 5wt.%, preferably 0.005 to 2wt.% based on the product. As the product to which this inhibitor is applicable, e.g. a dental composition such as a toothpaste, a mouth-wash, a troche, a tablet for gargling or an ointment, a food such as pasta, chewing gum or coffee beverage and a feed such as a dog food or a cat food are exemplified.
PCT No. PCT/US95/12445 Sec. 371 Date Jun. 11, 1997 Sec. 102(e) Date Jun. 11, 1997 PCT Filed Oct. 11, 1995 PCT Pub. No. WO96/11562 PCT Pub. Date Apr. 25, 1996A novel human radiation protecting checkpoint (RAP-1) gene and the RAP-1 protein encoded by the gene are disclosed. RAP-1 is believed to be involved in the regulation of cell cycle progression and/or programmed cell death (apoptosis). A human antisense RNA which can bind to the mRNA of the human RAP-1 protein, as well as the DNA from which the antisense RNA is transcribed are also disclosed. Additionally, a method for isolating DNA damage-monitoring checkpoint genes is described. The use of the DNA and RNA sequences and of the protein of the invention for the eary detection, prevention and/or treatment of cancer, AIDS and other diseases is also discussed.
Participants will be given a fotonovela and will meet once a month after they receive the fotonovela to discuss their thoughts on the materials they received. These discussion groups will last one hour and will consist of 10 participants.
The invention discloses a Chinese medicinal composition for treating inter-costal neuralgia. The Chinese medicinal composition is prepared from the following raw material medicaments in part by weight: 10 to 20 parts of root of straight ladybell, 15 to 25 parts of ophiopogon root, 25 to 35 parts of root of rehmannia, 10 to 20 parts of Chinese wolfberry, 15 to 25 parts of Chinese angelica, 6 to 15 parts of Szechwan chinaberry fruit, 3 to 8 parts of radix pseudo-ginseng, 10 to 20 parts of frankincense and 10 to 20 parts of elecampane. The Chinese medicinal composition adopts the compatibility though that: the Szechwan chinaberry fruit, the radix pseudo-ginseng, the frankincense and the elecampane are taken as monarchs; and the root of straight ladybell, the ophiopogon root, the root of rehmannia, the Chinese wolfberry and the Chinese angelica are taken as ministers. The Chinese medicinal composition fulfills the purpose of treating the inter-costal neuralgia by relieving pain, nourishing yin and promoting secretion. The medicaments are decocted by adding water according to a conventional method to form decoction, and also can be prepared into powder, tablets and capsules by adopting the conventional method. The Chinese medicament for treating the inter-costal neuralgia has the advantages of unique compatibility, skilful administration, very obvious effect of treating the inter-costal neuralgia, good treatment effect, low treatment cost and no side effect.
The invention discloses a formula of a Hui-nationality Chinese herbal pseudo-ginseng esophagus anti-cancer oral liquid and a preparation method thereof. The medicine is a green high-tech Chinese herbal medicine for treating esophageal cancer. The preparation method comprises the following steps: mixing Chinese herbal medicines such as pseudo-ginseng, glabrous sarcandra herb, caesalpinia sappan L., salammonite, etc. according to a certain ratio, adding water and decocting, extracting, and concentrating to obtain the traditional Chinese medicine oral liquid which is used for mainly treating esophageal cancer as well as treating digestive cancers such as pharyngolaryngeal cancer, gastric cancer, colorectal cancer, etc. The invention has the characteristic of moderate medicinal odour and dosage. The selected medicines are proved through pharmacology experiments of modern medicine to be capable of treating cancers. The medicine can fundamentally improve body functions at low cost and prevent and treat cell cancerization so as to recover body health.
Methadone may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is an increased risk in patients whose ability to maintain normal blood pressure is compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g. phenothiazines or general anesthetics) [see Drug Interactions (7)]. Monitor these patients for signs of hypotension after initiating or titrating the dosage of DISKETS Dispersible Tablets. In patients with circulatory shock, DISKETS may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of DISKETS in patients with circulatory shock.
The invention discloses a Pien Tze Huang hemorrhoids ointment and a preparation method thereof and belongs to the technical field of medicines. The Pien Tze Huang hemorrhoids ointment is prepared from the following crude drugs in parts by weight: 60-90 parts of Pien Tze Huang, 50-70 parts of amber, 41-59 parts of pearl powder, 10-20 parts of borneol, 10-40 parts of orange seeds, 10-30 parts of pawpaw, 20-30 parts of Chinese lobelia and 300-450 parts of white vaseline. The treatment efficiency of the prepared Pien Tze Huang hemorrhoids ointment reaches 95% or above; in addition, an application method of the Pien Tze Huang hemorrhoids ointment is simple; the Pien Tze Huang hemorrhoids ointment takes effects quickly and is short in treatment time; and less pain of a patient is realized. Therefore, the gospel is brought to the patient. Moreover, the Pien Tze Huang hemorrhoids ointment is used cooperatively with pills, so that internal factors of the body are regulated while the external application is carried out. Accoridngly, the hemorrhoids are treated externally and internally, and the treatment efficiency can reach 97% or above. Besides, the Pien Tze Huang hemorrhoids ointment has no toxic or side effects on the body and is safe and healthy.
Cardiac arrhythmias, including atrial fibrillation and atrial flutter, were reported in recipients of JAYPIRCA. Atrial fibrillation or flutter were reported in 3.2% of patients, with Grade 3 or 4 atrial fibrillation or flutter reported in 1.5% of 593 patients in the clinical trial [see Adverse Reactions (6.1)]. Other serious cardiac arrhythmias such as supraventricular tachycardia and cardiac arrest occurred in 0.5% of patients. Patients with cardiac risk factors, such as hypertension, or previous arrhythmias may be at increased risk. 

Monitor for signs and symptoms of arrhythmias (e.g., palpitations, dizziness, syncope, dyspnea) and manage appropriately. Based on severity, reduce dose, temporarily withhold, or permanently discontinue JAYPIRCA [see Dosage and Administration (2.2)].
NEW MATERIAL:The compound of formula I (X is 2-pyridyl or 4-pyridyl; A is 1-6C bivalent hydrocarbon residue). EXAMPLE:3-(2-Pyridyldithio)propanohydrazide. USE:A drug. An agent for introducing active disulfide group into a carbohydrate. An active disulfide group is introduced at a sugar chain into an antitumor antibody selectively bondable to tumor and the introduced product is made to react with a thiol-containing derivative of formula II of a carcinostatic agent methotrexate (MTX) to obtain an antitumor antibody-MTX complex having selective action to tumor. PREPARATION:The compound of formula I can be produced e.g. by reacting the compound of formula II with hydrazine in a polar solvent (e.g. ethyl acetate) in the presence of a dehydrative condensation agent (e.g. dicyclohexyl carbodiimide) at 0-50 deg.C for 1hr - 3 day.
Heart failure is a primary cause of global mortality. In the present study, whether larixyl acetate, an inhibitor of transient receptor potential cation channel subfamily C member 6, attenuates pressure overload‑induced heart failure in mice was investigated. To test this hypothesis, a transverse aortic constriction (TAC) animal model and an angiotensin II (Ang II)‑treated H9c2 cell model were used. Cardiac and cellular structure, function and the expression levels of hypertrophy, endoplasmic reticulum (ER) stress, apoptosis, autophagy and pmTOR/mTOR related mRNAs or proteins were assessed to explore the underlying molecular mechanisms. The results indicated that treatment with TAC or Ang II leads to significant hypertrophy and dysfunction of the heart or H9c2 cells, accompanied by an increase in ER stress, apoptosis and activation of the mTOR signaling pathway, and a decrease in autophagy. The administration of larixyl acetate attenuated these impairments, which can be reversed by inhibiting autophagy through the activation of the mTOR signaling pathway. These findings suggested that larixyl acetate can effectively protect against pressure overload‑induced heart failure by enhancing autophagy and limiting ER stress and apoptosis through inhibition of the mTOR pathway.
In the event of acute overdosage, reversible renal toxicity has been reported in some cases. The stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed and given supportive treatment, including monitoring of renal function and administration of magnesium, aluminum or calcium containing antacids which can reduce the absorption of ciprofloxacin. Adequate hydration must be maintained. Only a small amount of ciprofloxacin (< 10%) is removed from the body after hemodialysis or peritoneal dialysis.

Single doses of ciprofloxacin were relatively non-toxic via the oral route of administration in mice, rats, and dogs. No deaths occurred within a 14-day post treatment observation period at the highest oral doses tested; up to 5000 mg/kg in either rodent species, or up to 2500 mg/kg in the dog. Clinical signs observed included hypoactivity and cyanosis in both rodent species and severe vomiting in dogs. In rabbits, significant mortality was seen at doses of ciprofloxacin > 2500 mg/kg. Mortality was delayed in these animals, occurring 10 to 14 days after dosing.

In mice, rats, rabbits and dogs, significant toxicity including tonic/clonic convulsions was observed at intravenous doses of ciprofloxacin between 125 and 300 mg/kg.
FIELD: chemistry. ^ SUBSTANCE: in formula I Rf is an alkyl group containing 1-2 carbon atoms, in which 1-5 hydrogen atoms are substituted with 1-5 fluorine atoms, and R is an amine group or an amine group substituted with an amino acid residue of general formula NH(COCHR'NH)-H, where R' is hydrogen, a side chain of natural amino acid which is C1-C4alkyl, possibly substituted with a hydroxy group, a hydroxyl group, disodium or an ammonium phosphate group. The invention also relates to versions of the method of producing compounds of formula I, involving the following steps: fluoroalkylation of 4-hydroxy-3-methoxybenzaldehyde or 4-hydroxybenzaldehyde in the presence of an interphase transfer catalyst, to obtain 4-fluoroalkoxy-3-methoxybenzaldehyde (V) or 4-fluoroalkoxybenzaldehyde (VII), respectively, subsequent selective demethylation (V) with lithium diphenylphosphine and a protection of a hydroxy group or nitration (VII) in the 3rd position. The obtained compounds undergo Wittig reacton using a ylide of 3,4,5-trimethoxybenzyltriphenylphosphonium and the desired product is extracted. ^ EFFECT: obtaining novel combretastin derivatives of formula (I), having angiogenesis inhibiting activity, which can be used as anticancer and/or antiangiogenic agents. ^ 6 cl, 17 ex, 4 dwg
Subjects will be randomly assigned to the exenatide study treatment group or to the placebo study treatment group. Subjects will have a 33 percent chance of being assigned to the placebo study treatment group and a 66 percent chance of being assigned to exenatide study treatment. Subjects will not be able to choose the study group to which they will be assigned. All study participants will receive individualized dietary counseling based on food logs. Subjects who receive placebo will be assigned to follow a reduced-calorie diet in addition to study treatment. Subjects will not know whether they are receiving exenatide or placebo, but the unblinded members of the study team will know which they are receiving.
PURPOSE:To obtain a safe pure vegetable beautifying cosmetic without containing a chemical substance, by adding water or hot water to a tuberous root of KONJAK (devil's-tongue), as necessary, heated, dried material thereof or a mixture thereof with mugwort, gelatinizing the resultant blend, applying the obtained paste to the skin and washing the paste with water. CONSTITUTION:Water or hot water is added to (A) a tuberous root of KONJAK or dried material thereof, (B) heated tuberous root of the KONJAK or dried material thereof or (C) a mixture prepared by mixing the above-mentioned components (A) and (B) with mugwort to provide a pasty form and afford a pure vegetable cosmetic capable of safely beautifying the skin without irritation to the skin, since chemical substances are not contained at all. If the above- mentioned cosmetic is applied to respective parts (face, body, hands, legs, etc.) of the skin, it is well adsorbed on the skin so that enzymic proteins, etc., contained in the paste may capture stain and dirt latent in the skin. The paste is then washed with water to remove all the stain and dirt to clean the skin. Furthermore, the mugwort has unique beautifying action on the skin in addition to germicidal and preservative effects thereof.
PURPOSE: A skin external composition containing pseudoceramide complex including pseudoceramide and stearic acid is provided to ensure high moisture dipping ability and skin moisturization effect. CONSTITUTION: A pseudoceramide complex contains 10-90 weight% of pseudoceramide and stearic acid based on total weight. The complex further contains 0.0001-30 weight% of cholesterol. The pseudoceramide is denoted by one selected from chemical formulas 1 to 6. The weight ratio of pseudoceramide and stearic acid is 1:1, and pseudoceramide and cholesterol is 1:0.5. The skin external composition contains 0.01-40 weight% of the pseudoceramide complex. The composition is cosmetic composition or pharmaceutical composition.
This group will receive tummy time and parent education and be encouraged to perform tummy time on their own. They will utilize the PT Pal application to record their tummy time adherence. The primary investigator performs the intervention to the participants two times a day for 10 minutes for 4 weeks.