anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Introduction: Postoperative agitation is a common complication of sevoflurane anesthesia in children and might lead to self-harm and recovery disruption. This study aimed to compare the prophylactic effect of dexmedetomidine and remifentanil on postoperative agitation after anesthesia with sevoflurane. Methods: In this clinical trial, 60 children aged 2 to 7 years with ASA class І, II, candidates for elective strabismus surgery, were randomly assigned to three groups using block randomization. Patients in the first group D received 0.5 µgr/kg dexmedetomidine, the second group R received 0.1 µgr/kg remifentanil, and another group C received normal saline at the end of anesthesia. Children's agitation degree was measured by the Pediatric Anesthesia Emergence Delirium (PAED) scales and the 4-point agitation scale at the time of extubation, entering the recovery room, 10, 20, and 30 minutes after entrance. Data analysis was performed using descriptive and inferential statistical tests. Results: The postoperative agitation and pain were significantly lower among children who received dexmedetomidine compared with those in remifentanil and the control group (p < .001). It was observed that the administration of dexmedetomidine at the end of anesthesia significantly decreased the incidence of postoperative agitation (p < .001). None of the patients in group D had a PAED score of over 12. Conclusion: Based on PAED and the 4-point scales, none of the cases in group D had experienced postoperative agitation; this made a significant statistical difference compared with groups C and R (p-value <. 001). Although both dexmedetomidine and remifentanil can prevent and attenuate postoperative agitation, dexmedetomidine administration seems significantly more effective.
Treatment of whole blood comprises (i) removing whole blood from a patient and forming it into an extra corporeal stream; (ii) adding a chemotherapeutic agent (A) and a fluorescable tracer of formula (I) or its alkali metal salt. (I) being dialysable from the stream at a rate which is a function of the dialysis rate of (A); (iii) dialysing to remove (A) and (I); (iv) irradiating a portion of the dialysate with fluorescence exciting electromagnetic radiation; (v) detecting the fluorescence emitted by (I) and generating an electric signal indicative of the fluorescences intensity; (vi) energising an indicator with this signal; and (vii) returning the blood to the patient. In (I) R is H or Me; X is halogen or 1-2C alkoxy; n is 0 or 1. Opt. before irradiation (step (iv)) the dialysate is contacted, across a dialysis membrane with an aq. secondary dialysis soln. devoid of (I) and this aq. sec. dialysis soln. is recovered and irradiated etc. The method is esp. useful for determining the amt. of isocyanate remaining after haemodialysis. Extra corporeal treatment of blood with isocyanate is used in the treatment of sickle cell anaemia. As the removal rate of (I) during haemodialysis is a function of the removal rate of (A), the amt. of (A) is determined. (I) is physiologically tolerable, inert to blood proteins and compatible with (A).
Participants will be engaged in 30 hours of computer-based cognitive exercises with a standardized, widely used software package (Cogpack, Version 7.0, Marker Software), shown to improve cognitive functioning in multiple studies. One-hour sessions will be conducted 3 times per week for 10 weeks.
NEW MATERIAL:Novel substance K2919 or a salt thereof. USE:Useful as an antitumor agent or a remedy for tumor and showing antitumor activity against animal tumors, especially malignant tumors. PREPARATION:Strain K2919 (FERM P-9408) belonging to the genus Streptomyces is aerobically cultivated in a proper medium and the aimed substance is obtained from the culture mixture. The medium contains any nutritive source which the substance K2919 producing strain can use, and, for example, glucose is useful as a carbon source, soybean flour or ammonium salt are useful as a nitrogen source. Aerobic liquid culture is suitable as the culture method. The culture temperature is 20-37 deg.C, preferably 25-30 deg.C. The substance K2919 is collected from the culture mixture by extraction with ethyl acetate.
Participants assigned to the Treatment as Usual group will attend routine clinic visits at the Toronto Western Hospital Bariatrics Surgery Program (TWH-BSP). These visits generally include education on bariatric surgery and nutrition. Patients meet with select members of the multidisciplinary team at 1, 2, and 3 years post-surgery, and may attend an optional monthly support group. Participants' service utilization (i.e., attendance at optional sessions) will be documented and compared across groups.
Patients should be started with 1 nasal inhalation in each nostril twice daily; patients not adequately responding to 168 mcg or those with more severe symptoms may use 336 mcg (2 inhalations in each nostril). Once adequate control is achieved, the dosage should be decreased to 84 mcg (1 spray in each nostril) twice daily. BECONASE AQ Nasal Spray is not recommended for children below 6 years of age.

The maximum total daily dosage should not exceed 2 sprays in each nostril twice daily (336 mcg/day).

In patients who respond to BECONASE AQ Nasal Spray, an improvement of the symptoms of seasonal or perennial rhinitis usually becomes apparent within a few days after the start of therapy with BECONASE AQ Nasal Spray. However, symptomatic relief may not occur in some patients for as long as 2 weeks. BECONASE AQ Nasal Spray should not be continued beyond 3 weeks in the absence of significant symptomatic improvement.

The therapeutic effects of corticosteroids, unlike those of decongestants, are not immediate. This should be explained to the patient in advance in order to ensure cooperation and continuation of treatment with the prescribed dosage regimen.

In the presence of excessive nasal mucous secretion or edema of the nasal mucosa, the drug may fail to reach the site of intended action. In such cases it is advisable to use a nasal vasoconstrictor during the first 2 to 3 days of therapy with BECONASE AQ Nasal Spray.
Enhanced usual care will be standardized across sites with transition/transfer of care checklists that will be used at all sites. Enhanced usual care will minimally include (1) patient seen by the pediatric provider with the parent outside the examination room, (2) a social work consult to screen and address sociodemographic risk factors, (3) information on health insurance adequacy provided to patient, (4) adult hematologist identified, (5) adult primary care provider identified, (6) medical release signed, and (7) medical record viewable or sent to adult provider.
INTRODUCTION: Pseudotumor cerebri (PC) in prepubertal patients displays certain characteristics that differentiate it from its presentation at the postpubertal stage. The aim of this study is to describe the characteristics of paediatric patients diagnosed with PC at our centre and to compare them according to their pubertal status.
PATIENTS AND METHODS: We included patients aged between 1 and 18 years who were diagnosed with PC in a tertiary-level hospital between 2006 and 2019 and who met the updated diagnostic criteria for PC. They were classified according to body weight and pubertal status. Subsequently, we analysed results from lumbar punctures, neuroimaging studies, ophthalmological assessments, and treatments received during follow-up.
RESULTS: We included 28 patients, of whom 22 were of prepubertal age and 6 were of postpubertal age. The mean age (standard deviation) was 9.04 (2.86) years. Among the postpubertal patients, 83.3% were boys, 66.7% of whom presented overweight/obesity. In the group of prepubertal patients, 27% were boys, 31.8% of whom were overweight. The most frequent symptoms were headache (89.9%) and blurred vision (42.9%). All patients presented papilloedema, and 21.4% manifested sixth nerve palsy. Possible triggers were identified in 28.6% of cases. Nineteen percent of patients presented clinical recurrence, all of whom were prepubertal patients. Complete clinical resolution was achieved in 55.6% of patients.
CONCLUSION: Prepubertal patients with PC show lower prevalence of obesity, higher prevalence of secondary aetiologies, and higher recurrence rates than postpubertal patients.
PURPOSE:To prepare the titled cosmetic capable of keeping a component which is extremely unstable in water with little decomposition and deactivation with time, by adding a drug component or a cosmetic component to a base composed mainly of a film-forming water-soluble polymer and water, and forming the mixture to a film. CONSTITUTION:A vehicle selected from film-forming water-soluble polymers (preferably alpha-1,6-maltotriol) is mixed with water at a ratio of (5-25):(95-75), and a drug component or a cosmetic component (e.g. ascorbic acid, enzyme, etc.) is dissolved or dispersed in the solution to obtain a pasty composition, which is formed to a thin film by casting, and dried to obtain a dried film cosmetic having a thickness of 50-200mu. As an alternative, the composition is applied uniformly to a substrate (the thickness of the applied film is preferably 10-several tens microns) and dried to obtain a laminate film cosmetic having a thickness of 50-200mu. The amount of ascorbic acid and enzyme in the dried final product are preferably 0.5-2% and 0.02-0.5%, respectively.
Nursing education plays an important role in providing the knowledge, skills and critical thinking abilities needed to provide quality care. Innovative teaching strategies provide quality education. These methods, such as cooperative learning and concept maps, help them to criticize and apply their knowledge. It is important to integrate these strategies in oncology nursing education, which involves complex treatment processes and symptom management. Collaborative learning with concept maps can contribute to the development of a more holistic understanding of oncology care. This study was planned to examine the effect of collaborative learning approach with concept maps on nursing students' knowledge learning about symptom management of oncologic patients.
In a group of 24 elderly subjects aged 63 to 79 years administered a single ramelteon tablets 16 mg dose, the mean Cmax and AUC0-inf values were 11.6 ng/mL (SD, 13.8) and 18.7 ng•hr/mL (SD, 19.4), respectively. The elimination half-life was 2.6 hours (SD, 1.1). Compared with younger adults, the total exposure (AUC0-inf) and Cmax of ramelteon were 97 and 86% higher, respectively, in elderly subjects. The AUC0-inf and Cmax of M-II were increased by 30 and 13%, respectively, in elderly subjects.

Gender

There are no clinically meaningful gender-related differences in the pharmacokinetics of ramelteon tablets or its metabolites.

Hepatic Impairment

Exposure to ramelteon tablets was increased almost four-fold in subjects with mild hepatic impairment after seven days of dosing with 16 mg/day; exposure was further increased (more than ten-fold) in subjects with moderate hepatic impairment. Exposure to M-II was only marginally increased in mildly and moderately impaired subjects relative to healthy matched controls. The pharmacokinetics of ramelteon have not been evaluated in subjects with severe hepatic impairment (Child-Pugh Class C). Ramelteon tablets should be used with caution in patients with moderate hepatic impairment [see Warnings and Precautions (5.6)].

Renal Impairment 

The pharmacokinetic characteristics of ramelteon tablets were studied after administering a 16 mg dose to subjects with mild, moderate, or severe renal impairment based on predose creatinine clearance (53 to 95, 35 to 49, or 15 to 30 mL/min/1.73 m2, respectively), and in subjects who required chronic hemodialysis. Wide intersubject variability was seen in ramelteon tablets exposure parameters. However, no effects on Cmax or AUC0-t of parent drug or M-II were seen in any of the treatment groups; the incidence of adverse events was similar across groups. These results are consistent with the negligible renal clearance of ramelteon, which is principally eliminated via hepatic metabolism. No adjustment of ramelteon tablets dosage is required in patients with renal impairment, including patients with severe renal impairment (creatinine clearance of ≤30 mL/min/1.73 m2) and patients who require chronic hemodialysis.
The invention provides a gRNA (ribonucleic acid), AAV8-CRISPR (clustered regularly interspaced short palindromic repeats)/Cas 9 system of a target miR-29b and application thereof, belonging to the technical field of genetic engineering. The invention provides a gRNA of a target miR-29b, and a nucleotide sequence of the gRNA is shown in SEQ ID No. 1. The gRNA has stronger specific binding capacity on miR-29b on a cell level, has a targeted editing function only on miR-29b, has no influence on miR-29a and miR-29c of the same family, has stronger editing efficiency, and can effectively inhibit the expression of miR-29 b. An AAV8-CRISPR/Cas9 system comprising the gRNA targeting miR-29 b. The application of a gRNA or AAV8-CRISPR/Cas9 system of a target miR-29b in preparing a medicament for treating muscle atrophy.
Sodium valproate is an established antiepileptic drug used against a broad range of seizure types. Lamotrigine, a newer antiepileptic drug available since late 1980s, has a similar range of action and is approved as first-line treatment for epilepsy in the United States and many European countries as well as in Hong Kong. Recently, concern has been raised over the association between valproate treatment and polycystic ovarian syndrome, a condition characterised by multiple cysts in the ovaries in women and a range of hormonal and metabolic disturbances. Cross-sectional studies from Finland suggest that up to 40% of women treated with valproate have polycystic ovaries. Lamotrigine substitution for valproate has been reported to normalise these parameters in some patients. Elevated serum insulin and androgen levels have also been reported in over 50% of male patients taking valproate for epilepsy. However, such high incidence of hormonal abnormalities associated with valproate treatment has not been reproduced in studies conducted in other western populations. No similar studies in Chinese patients have been reported. In addition, these cross-sectional studies suffer from many potential confounding factors, such as previous treatment with other antiepileptic drugs, variation in duration of treatment, thus limiting the ability to establish a causal relationship.

This phase IV study aims to examine whether valproate treatment is associated with hormonal abnormalities in Chinese epilepsy patients. Newly diagnosed patients will be randomised to receive valproate or lamotrigine and their hormonal profiles measured prospectively for 12 months.
BACKGROUND: Chronic rhinosinusitis (CRS) is thought to result from complex interactions between the host immune system, microbiota, and environmental exposures. Currently, there is limited data regarding the impact of ambient particulate matter ≤2.5 μm in diameter (PM2.5) in the pathogenesis of CRS, despite evidence linking PM2.5 to other respiratory diseases. We hypothesized that PM2.5 may result in differential cytokine patterns that could inform our mechanistic understanding of the effect of environmental factors on CRS.
METHODS: We conducted an analysis of data prospectively collected from 308 CRS patients undergoing endoscopic sinus surgery. Cytokines were quantified in intraoperative mucus specimens using a multiplex flow cytometric bead assay. Clinical and demographic data including zip codes were extracted and used to obtain tract-level income and rurality measures. A spatiotemporal machine learning model was used to estimate daily PM2.5 levels for the year prior to each patient's surgery date. Spearman correlations and regression analysis were performed to characterize the relationship between mucus cytokines and PM2.5. RESULTS: Several inflammatory cytokines including IL-2, IL-5/IL-13, IL-12, and 21 were significantly correlated with estimated average 6, 9, and 12-month preoperative PM2.5 levels. These relationships were maintained for most cytokines after adjusting for age, income, body mass index, rurality, polyps, asthma, and allergic rhinitis (AR) (p < .05). There were also higher odds of asthma (OR = 1.5, p = .01) and AR (OR = 1.48, p = .03) with increasing 12-month PM2.5 exposure. Higher tissue eosinophil counts were associated with increasing PM2.5 levels across multiple timeframes (p < .05).
CONCLUSIONS: Chronic PM2.5 exposure may be an independent risk factor for development of a mixed, type-2 dominant CRS inflammatory response.
BACKGROUND: Primary hyperparathyroidism is an endocrine disease and a common cause of nonmalignant hypercalcemia, often discovered incidentally in asymptomatic patients. The case reported herein illustrates that significant hormonal imbalances can present with unexpectedly mild clinical manifestations.
CASE PRESENTATION: We describe a 47-year-old Caucasian male with two episodes of kidney stones and otherwise no symptoms of severe hypercalcemia. In our case, fasting emerged as a potential risk factor for the development of renal stones. The diagnosis was primary hyperparathyroidism. The intervention consisted of preoperative fluids and cinacalcet while awaiting surgery. Despite initial stability, the patient experienced a subsequent increase in ionized calcium and parathyroid hormone levels, becoming symptomatic with fatigue, tremors, and heart palpitations. This progression led to a diagnosis of a hypercalcemic crisis, and the plan was accelerated. An acute parathyroid scintigraphy and an ultrasound was performed and revealed a giant intrathoracic parathyroid adenoma. After surgical removal of the adenoma, he developed hungry bones and biochemical remission. The patient has received three extracorporeal shock wave lithotripsy treatments for a stone in the upper left kidney, but as of a computed tomography scan on 9 February 2024, the stone remains unchanged. Owing to the stone's resistance to extracorporeal shock wave lithotripsy and the absence of symptoms, no further treatment is planned. Endoscopic laser treatment (retrograde intrarenal surgery) is an option, but for now, the situation will be monitored.
CONCLUSION: This case report underscores that extremely elevated levels of calcium and parathyroid hormone along with a rare giant parathyroid adenoma may not necessarily present with symptoms indicative of a calcium crisis. Additionally, management of such rare giant parathyroid adenomas requires careful monitoring and a tailored approach to address potential postsurgical complications such as hungry bone syndrome.
Tris(hydroxymethyl)aminomethane acetylsalicylate (I) of the formula:- Analgetic and antiphlogistic. (I) is readily soluble in water, and is rapidly resorbed after oral administration (thus giving better analgesic action than free acetylsalicyclic acid). The salt is crystalline and has unlimited stability, and is suitable for administration in conventional oral dosage forms or as an injection. Test results demonstrating that (I) is less toxic and more active as an analgetic and antiphlogistic than acetylsalicyclic acid are given in the specification. Also given are results showing the better blood salicylic acid levels achieved after oral and i.m. administration.
The wastewater treatment system comprises an electromagnetic signal generator, a printed circuit board (PCB) antenna (10) with an insulating layer, and fastener cables (14) connected to walls of an aeration basin (12). The generator is arranged for supplying the PCB antenna through the cables with electromagnetic signals (16). The PCB antenna is fixed to the walls of the basin by the fastener cables. The frequency of the electromagnetic signal generated by the generator is 10-100 Hz or 2000-7000 Hz. The electromagnetic signal is a continuous positive signal or alternating signal. The wastewater treatment system comprises an electromagnetic signal generator, a printed circuit board (PCB) antenna (10) with an insulating layer, and fastener cables (14) connected to walls of an aeration basin (12). The generator is arranged for supplying the PCB antenna through the cables with electromagnetic signals (16). The PCB antenna is fixed to the walls of the basin by the fastener cables. The frequency of the electromagnetic signal generated by the generator is 10-100 Hz or 2000-7000 Hz. The electromagnetic signal is a continuous positive signal or alternating signal, and circulates in a closed or open circuit. The PCB antenna: is made of epoxy; comprises a conductive layer in which two current flow circuits with a track for an electromagnetic signal is etched, and a copper layer without etching; and has a dimension of 0.3-1.5 m or 0.3-3 m. A unit is arranged for connecting one PCB antenna in series or parallel to other PCB antennas in the basin. The voltage supply for the antenna is 5-100 V RMS. An independent claim is included for a process for electromagnetic treatment of wastewater contained in an aeration basin or a settling or thickening basin of a wastewater treatment plant.
Delefilcon A contact lens randomly assigned to one eye, with narafilcon A contact lens in the fellow eye for contralateral wear. Both products worn in a daily wear, daily disposable mode approximately 8 hours a day for approximately 1 week, with spectacles worn over contact lenses if needed to provide acceptable vision.
FIELD: medicine, particularly, oncology; applicable in postoperative period in multimodality therapy of brain malignant tumors. SUBSTANCE: method includes course of chemotherapy with preparations of nitrosurea and radiotherapy, and administration of blockader of calcium receptors 3-7 days before chemoradiation therapy and during the entire course of therapy. Calcium antagonist is administered in the form of nifelate by 20-30 mg three times a day. The method allows increase of nonrecurrence period of life of patient with brain tumor, causes no side negative reactions of cardiovascular system and gastroenteric tract, no brain edema; and results in no sharp aggravation of blood quotient. EFFECT: extended range of patients with permissible multimodality therapy of brain tumor. 2 ex
With the rising need for accessible cervical cancer screening, self-sampling methods offer a promising alternative to traditional physician-led sampling. This study aims to evaluate the efficacy of the HygeiaTouch Self Sampling Kit for Women in detecting human papillomavirus (HPV) types and predicting cervical lesions. We studied the concordance in identifying high-risk HPV (hrHPV) types between samples collected by physicians and those self-collected by women using a self-sampling kit for validation. Women aged 21-65, fitting into specific categories based on their cervical health history were eligible. Cohen's kappa coefficient to gauge concordance between the two specimen types and relative accuracy metrics in identifying cervical intraepithelial neoplasia (CIN) were also calculated, with physician-sampled specimens serving as a reference. A total of 1210 participants from three institutes were involved. The self-sampling kit closely matched the physician-led method in terms of collecting valid specimens (100% vs. 100%), identifying hrHPV types (kappa: 0.75, 95% confidence interval [95% CI]: 0.72-0.79; agreement: 87.7%, 95% CI: 85.8-89.6) and predicting CIN grade 2 or worse (CIN2+) (relative sensitivity: 0.949, relative accuracy: 0.959). Kappa values varied between 0.71 and 0.83 for different hrHPV types and combinations, with an overall value 0.75 (95% CI: 0.72-0.79) signifying robust compatibility between the two methods. Our study underscores the potential of the HygeiaTouch Self Sampling Kit as a reliable, efficient, and user-friendly alternative to traditional sampling methods. This suggests that self-sampling could be pivotal in expanding cervical cancer screening accessibility and enhancing detection rates.
In the experimental group will proceed to the explanation of sleep hygiene measures to improve the quality of sleep. After 3 months, at the next health check, the quality of sleep questionnaire will be carried out together with the blood extraction.