anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain the subject safe and readily usable derivative, containing a carbazole skeleton, having hyperactivity suppressing action on intracerebral dopamine- based nervous systems, having excellent improving ratio for problem behaviors caused by schizophrenia, cerebrovascular disorder and jeriafoic dementia and useful as medical products, etc. CONSTITUTION:A 4-alkoxyphenethylamine expressed by formula I (Ra' is H or 1-5C alkyl; (n) is 1-3) is reacted with an acid chloride expressed by the formula RbCOC1 (Rb is 1-5C alkyl) to provide an acid amide derivative, which is then reduced to afford an amine derivative. The resultant amine derivative is subsequently reacted with an acid chloride expressed by the formula RcCOC1 (Re is the same kind as that of Rb) to provide an acid amide derivative, which is then nitrated with concentrated nitric acid and reduced to produce amino group. The produced amino group is acetylated and subsequently reacted with o-nitrobromobenzene to afford a compound expressed by formula II (Ac is acetyl). The nitro group is then reduced and treated with sodium nitrite to carry out cyclizing reaction. Thereby, a carbazole ring is produced to provide a compound expressed by formula III. The acid amid group in the resultant compound is reduced and the protecting group of the hydroxyl group, as necessary, is removed to afford the objective compound expressed by formula IV (Ra is H or Ra').
Patients should receive the best available first-line therapy, usually a combination therapy, based on the in vitro susceptibility results of the pre-treatment screening swab in combination to Pentaglobin 5ml/kg over a 12h i.v. infusion for 3 consecutive days.
This Special Issue of the Journal of Physiology and Biochemistry contains 7 contributions that have been elaborated in the context of the mini-network "Consortium of Trans-Pyrenean Investigations on Obesity and Diabetes" (CTPIOD), which is on its 19th year of existence. This scientific community, mostly involving research groups from France and Spain, but also open to participants coming from other countries, is focused on investigating the molecular and physiological mechanisms implicated in the development of obesity, diabetes, non-alcoholic fatty liver disease, and other noncommunicable diseases, as well as new preventive and therapeutic strategies. This special issue covers novel nutritional, molecular, and physiological aspects related to these metabolic diseases. Some of these papers emerge from the lectures of the 19th Conference on Trans-Pyrenean Investigations in Obesity and Diabetes, organized by the University of Zaragoza and celebrated in the town of Jaca (Spain) on 17-18th October 2022, and have been prepared in collaboration between different groups of the network. Many lectures were focused on the preventive role of specific fatty acids, dietary phenolic compounds and other phytochemicals against metabolic disorders. Consequently, we encouraged submission of original research in this field for this special issue.
Visual analysis of the current status, research hotspots, evolving trends, and future prospects in the field of thiamine-responsive megaloblastic anemia syndrome (TRMA), providing new insights and directions for subsequent research on the pathogenic mechanisms and prevention strategies of TRMA. Taking the core database of Web of Science as the literature source, selecting TRMA-related literature records published from 1997 to 2023 as the research object, and using R software and Citexs database to conduct visual analysis and discussion of the research content. The results showed that a total of 89 publications related to the topic were published from 1997 to 2023, with an average annual publication volume of 3 papers. Classified by country, it was found that the United States, and Israel among other countries and institutions, published a significant number of papers. Through keyword frequency analysis, high frequencies of keywords such as diabetes, deafness, thiamine-responsive megaloblastic anemia, and mutations in the solute carrier family 19 member 2 (SLC19A2) gene were observed, indicating that to date, these keywords have been the main research directions, highlighting a gradually reached consensus on the mechanism exploration of TRMA. In conclusion, TRMA research focuses on the mechanisms of hot topics such as diabetes, deafness, and thiamine-responsive megaloblastic anemia, and the core gene SLC19A2 research may currently become a new breakthrough point for future molecular studies.
BACKGROUND: The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the clinical implication remains disputed.
METHODS: A broad-spectrum peptide library, which consists of 103 functionally validated CD8+ T-cell epitopes spanning overall HBsAg, HBeAg, HBx and HBpol proteins and fits to the HLA polymorphisms of Chinese and Northeast Asian populations, was grouped into eight peptide pools and was used to establish an ELISpot assay for enumerating the reactive HBV-specific T cells in PBMCs. Totally 294 HBV-infected patients including 203 ones with chronic hepatitis B (CHB), 13 ones in acute resolved stage (R), 52 ones with liver cirrhosis (LC) and 26 ones with hepatocellular carcinoma (HCC) were detected, and 33 CHB patients were longitudinally monitored for 3 times with an interval of 3-5 months.
RESULTS: The numbers of reactive HBV-specific T cells were significantly correlated with ALT level, HBsAg level, and disease stage (R, CHB, LC and HCC), and R patients displayed the strongest HBV-specific T cell reactivity while CHB patients showed the weakest one. For 203 CHB patients, the numbers of reactive HBV-specific T cells presented a significantly declined trend when the serum viral DNA load, HBsAg, HBeAg or ALT level gradually increased, but only a very low negative correlation coefficient was defined (r = - 0.21, - 0.21, - 0.27, - 0.079, respectively). Different Nucleotide Analogs (NUCs) did not bring difference on HBV-specific T cell reactivity in the same duration of treatment. NUCs/pegIFN-α combination led to much more reactive HBV-specific T cells than NUCs monotherapy. The dynamic numbers of reactive HBV-specific T cells were obviously increasing in most CHB patients undergoing routine treatment, and the longitudinal trend possess a high predictive power for the hepatitis progression 6 or 12 months later.
CONCLUSION: The presented method could be developed into an efficient reference method for the clinical evaluation of cellular immunity. The CHB patients presenting low reactivity of HBV-specific T cells have a worse prognosis for hepatitis progression and should be treated using pegIFN-α to improve host T-cell immunity.
Participants received a single bolus dose of 0.1 mg/kg vecuronium prior to intubation. The neuromuscular block was maintained with 0.015 mg/kg vecuronium if needed. At 1-2 PTC and after the last dose of vecuronium, a single bolus dose of 70.0 μg/kg neostigmine (up to a maximum dose of 5 mg) was administered in combination with 14.0 μg/kg glycopyrrolate.
Participants complete 1 questionnaire at beginning of study, 1 after receiving education about how to protect skin from sun and how to avoid tanning beds, and 1 at about 3 months after receiving skin protection education. Participants given handouts that discusses skin cancer prevention, sun protection, and how to avoid tanning beds.
The creative visual artist will assess interest in spending time using the materials provided. Participants will be offered watercolor painting, drawing, or adult coloring. There will be a guided activity based on their art making preference. A standardized prompt will be utilized for both writing and visual art sessions. The duration of the intervention will be determined by participant interest and tolerance, but not to exceed 60 minutes. For remote follow-up sessions, participants will be supplied with a small art kit to use at home.
Vertebrate scavengers represent important taphonomic agents that can act on a body, particularly when in an outdoor environment. Understanding the effects of these agents will direct how and where to search for human remains and influence the likelihood of discovery in a particular region. The current study aimed to identify the taphonomic impact of scavenger guilds in the peri-urban and rural regions of southeastern British Columbia. Vertebrate scavenger activity on pig carcasses was recorded remotely using trail cameras and analyzed to determine temporal scavenging profiles. Both the peri-urban and rural environments produced comparable scavenger guilds, namely: turkey vultures, American crows/northern ravens (classified as "corvids"), American black bears, and coyotes. Although the two locations had different study lengths due to variable degrees of scavenging, for the period that was common to both locations (summer to early fall), the black bear was the most frequent scavenger followed by coyote. However, the dispersal of remains by the mammalian scavengers was distinctly different between sites. Only 12%-33% of skeletal elements were recovered at the rural sites compared to 80%-90% recovered at the peri-urban sites, even though the latter sites had a longer study timeframe. The extended timeframe of the peri-urban sites confirmed that certain scavengers (e.g., turkey vultures and black bears) are only seasonally active in this region. These findings demonstrate the variability of scavenger behavior and the need to assign caution and local ecological knowledge when predicting scavenger trends. Such taphonomic information is relevant for human remains searches in regions with comparable scavenger guilds.
INTRODUCTION: Empagliflozin is a sodium-glucose co-transporter-2 inhibitor used to treat type 2 diabetes (T2D) to improve glycemic control, reduce risk of cardiovascular death in patients with T2D, and treat patients with symptomatic chronic heart failure (HF) and chronic kidney disease (CKD). The safety profile of empagliflozin is well documented, although adverse events (AEs) remain of interest to clinicians. This study provides an up-to-date safety evaluation of empagliflozin.
METHODS: Data were pooled from four long-term trials which included: patients with T2D and established cardiovascular disease (EMPA-REG OUTCOME), patients with HF, with/without diabetes (EMPEROR-Reduced and EMPEROR-Preserved), and patients with CKD, with/without diabetes (EMPA-KIDNEY). Since three of the four trials evaluated empagliflozin 10 mg, the meta-analysis was restricted to this dose.
RESULTS: Total trial medication exposure was 19,727 patient-years for patients who received empagliflozin (n = 10,472) and 19,447 patient-years for placebo (n = 10,461). The percentages of patients with serious AEs, fatal AEs, and AEs leading to discontinuation were similar for both groups. The incidences of serious urinary tract infection and serious pyelonephritis or urosepsis were similar for both groups but higher for women taking empagliflozin versus placebo. Serious genital infections were not increased with empagliflozin versus placebo. There was a slight increase in ketoacidosis and serious volume depletion in patients who received empagliflozin versus placebo. The occurrence of serious acute kidney injury was lower with empagliflozin versus placebo. Empagliflozin was not associated with an increased incidence of severe hypoglycemia, bone fractures, or lower limb amputations. Empagliflozin is therefore considered safe in people without diabetes, the elderly, patients with very low estimated glomerular filtration rate, low body mass index, and HF. Safety is unaltered by blood pressure, concomitant medication for hypertension, HF, and immunosuppression.
CONCLUSION: This meta-analysis of long-term safety data extends current knowledge and confirms the safety and tolerability of empagliflozin.
It is intended to provide organ fibrosis inhibitors, in particular, liver fibrosis inhibitors which contain as the active ingredients histidine, preferably together with cysteine and/or cystine. Owing to the combined use, a remarkable effect of inhibiting organ fibrosis, in particular, liver fibrosis can be established. These substances are usable as the desired active ingredients in the forms appropriate for using in drugs, foods and drinks. It is also intended to provide organ fibrosis inhibitors comprising the active ingredients as described above either separately or as a combination of one of them with a mixture of the other two ingredients. Thus, it is possible to present organ fibrosis inhibitors such as liver fibrosis inhibitors which are applicable in the forms appropriate for using not only in drugs for various organ diseases caused by fibrosis (liver diseases, etc.) but also in foods with health claims for improving and maintaining liver functions and foods and drinks for sick persons.
A pre-adjusted edgewise fixed appliance (3M Gemini Uniteks, 0.022" Roth prescription brackets.Teeth alignment in this group started using round 0.014" NiTi arch wire. The 0.014" NiTi arch wire was placed into the slots of the brackets and tied with elastomers by figure of 8. During this stage, only tipping movement was applied.
The invention provides a method for preparing a traditional Chinese medicine lotion for treating wet frostbites, belonging to the technical field of traditional Chinese medicine preparation methods. At present, the wet frostbites are generally treated with sulfonamides and antibiotics. Kanamycin has toxicity towards the auditory nerves and kidneys. The invention adopts the following technical scheme: taking Sichuan pepper, fructus evodiae, monkshood, Tianxiong, radix aconitis carmichaeli, asarum, peppers, long pepper, cubeb, fennel, leek, galangal, fructus cnidii, chillies, caraway, rhizoma kaemferiae, earthworms, stiff silkworms, scorpio, chilopod, herba schizonepetae, divaricate saposhnikovia root, radix angelicae, cinnamon and liquorice, soaking the above 25 traditional Chinese medicines in water, then decocting the medicines with slow fire and filtering the decoction to remove the residues, thus obtaining the decocted liquid medicine, namely the traditional Chinese medicine for treating wet frostbites. The method has the following advantages: the prepared liquid traditional Chinese medicine has low toxic or side effect, short course of treatment and high recovery rate and uses the monarch, minister, assistant and guide just right. The adverse reactions, allergic reactions and toxic reactions caused by such western medicines as sulfonamides and antibiotics are avoided while the traditional Chinese medicine is applied.
Adhesion G-protein-coupled receptors (aGPCRs) form a large family of cell surface molecules with versatile tasks in organ development. Many aGPCRs still await their functional and pharmacological deorphanization. Here, we characterized the orphan aGPCR CG11318/mayo of Drosophila melanogaster and found it expressed in specific regions of the gastrointestinal canal and anal plates, epithelial specializations that control ion homeostasis. Genetic removal of mayo results in tachycardia, which is caused by hyperkalemia of the larval hemolymph. The hyperkalemic effect can be mimicked by a raise in ambient potassium concentration, while normal potassium levels in mayoKO mutants can be restored by pharmacological inhibition of potassium channels. Intriguingly, hyperkalemia and tachycardia are caused non-cell autonomously through mayo-dependent control of enterocyte proliferation in the larval midgut, which is the primary function of this aGPCR. These findings characterize the ancestral aGPCR Mayo as a homeostatic regulator of gut development.
The symptoms described in connection with deliberate esomeprazole overdose (limited experience of doses in excess of 240 mg/day) are transient. Reports of overdosage with omeprazole in humans may also be relevant. Doses ranged up to 2,400 mg (120 times the usual recommended clinical dose). Manifestations were variable, but included confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, dry mouth, and other adverse reactions similar to those seen at recommended dosages. See the full prescribing information for oral omeprazole for complete safety information. No specific antidote for esomeprazole is known. Since esomeprazole is extensively protein bound, it is not expected to be removed by dialysis. In the event of overdosage, treatment should be symptomatic and supportive.  
  
  
If over-exposure occurs, call your Poison Control Center at 1-800-222-1222 for current information on the management of poisoning or overdosage.
Traditional systems of healing, such as shamanism, do not readily lend themselves to conventional research methods, yet studying their effectiveness is especially germane in the case of chronic conditions that involve an emotional component and that elude allopathic treatment regimens. Temporomandibular joint disorders (TMDs), which affect up to 10% of the adult population, are a prime example of such conditions. Traditional treatment outcomes for TMD pain are often unsatisfactory. Moreover, in women age 25-55 (the age-sex group most affected), TMD is often found in association with depression, anxiety, sleep disturbances, gastrointestinal symptoms, frequent infection,and fibromyalgia. Because these multiple and complex symptoms suggest a loss of spirit or life energy, they may be particularly susceptible to treatment by shamanic (spiritual) healing, which aims to bring disturbed physical, mental, and emotional systems into balance. This phase I study will develop methods to evaluate shamanic healing as an intervention for TMD and will evaluate the feasibility of conducting randomized clinical trials of shamanic healing.
1,255,437. Tablet lubricant. GRUPPO LEPETIT S.p.A. 14 April, 1970 [24 April, 1969], No. 17690/70. Heading A5B. A tablet lubricant comprises sodium benzoate and 3-6% by weight of a liquid additive selected from: liquid petrolatum, dimethylpolysiloxanes with a viscosity below 1000 centistokes and polyoxyethylene glycols having viscosities between 200 and 6000 centistokes. The lubricant may be prepared by slurrying sodium benzoate with a solution of the additive in a volatile solvent e.g. CH 2 Cl 2 , CHCl 3  or CCl 4 , removing the solvent by evaporation and grinding the resultant. The lubricant is especially useful for effervescent pharmaceutical tablets, examples of which are given in which the medicaments are ascorbic acid, 16α-methylprednisone hemisuccinate, prednisone hemi succinate and aspirin.
Various scoring systems have been used to predict mortality and morbidity after congenital heart surgery. While the ideal system is still controversial, the technical performance score (TPS) has recently gained popularity. In this study, was investigated the effect of the TPS in predicting mortality and morbidity in pediatric patients who underwent congenital heart surgery in our clinic. Patients aged < 18 years who underwent congenital heart surgery between 2020 and 2023, were retrospectively analyzed. The patients' TPS categorizations were assigned according to their echocardiographic results at discharge and whether they required reintervention. The primary endpoints of the study were mortality (death within 30 days postoperatively) and morbidity. The secondary endpoint was a comparison of the effectiveness of TPS with that of the widely used Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery score. Included in this study were 1075 patients. The median patient age was 3 months (interquartile range, 1-5 months). The mortality and morbidity rates were 11% and 24%, respectively. Of the patients, 60% were categorized as TPS I (optimal), 25% as TPS 2 (adequate, minimal residual defect), and 15% as TPS 3 (inadequate, hemodynamically significant residual defect). Being categorized as TPS 3 was associated with mortality, prolonged ICU stay, and major adverse events. The predictive power of TPS for mortality and morbidity was an area under the receiver operating characteristic curve (AUC) of 0.810 (95% CI: 0.79-0.839, P < .001) and 0.78 (95% CI: 0.76-0.80, P < .001), respectively. These values were similar to those of the Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery score (0.81 vs 0.83 and 0.78 vs 0.80 for mortality and morbidity, respectively). In patients with highly heterogeneous congenital heart disease, the use of intraoperative TPS may be helpful in predicting mortality and morbidity.
PURPOSE:To obtain an insect gall fruit of Actinidia polygama usable as a raw material for fruit wine in an optional period by absorbing ingredients of other medicated plants in the insect gall fruit of the Actinidia polygama and freeze-drying the resultant substance. CONSTITUTION:Crude drug ingredients, such as seed, rhizome or leaf of Asparagus cochinchinensis Merr., Rubia akane Nakai, Torilis japonica DC., Epimedium grandiflorum Morr. var. thunbergianum Nakai, etc., are extracted with dilute ethanol to prepare a permeation liquid. An insect gall fruit of Actinidia polygama just after collection thereof is separately washed with water by rubbing to remove sticking foulings and calyxes. The resultant fruit is then dipped in the afore-mentioned permeation liquid for 3-10hr. The insect gall fruit absorbing the plural crude drug ingredients is then freeze-dried at -15 to -20 deg.C and used as a raw material for fruit wine at a desired time.
Consumption of 589,62 ml of product 1 (corresponding to 25g of glucose). Subjects will take this amount only on the day of the visit that they are to consume this product.
The present invention provides a use of probiotic for preparing a skin care composition, wherein the probiotic includes Lactobacillus plantarum GMNL-6, and the depository number is BCRC 910777 or CCTCC M 2017765. The composition can be a liniment for external use, a medicine for external use, a skin care product for external use, or a cosmetic. The composition is provided with an effect of improving skin condition or aesthetic appearance by facilitating collagen secretion or expression of ceramide synthase. In addition, the Lactobacillus plantarum GMNL-6 is a dead bacterium obtained by treating a bacterial solution under high temperature and high pressure. The topical skin care product includes a toner, a lotion, a skin protective cream, a moisturizing liquid, a lip balm, a beauty mask and a facial cleanser. The composition may further include pharmaceutically and cosmetologically acceptable carriers.