anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
After the termination of zero-COVID-19 policy, the populace in China has experienced both Omicron BA.5 and XBB waves. Considering the poor antibody responses and severe outcomes observed among the elderly following infection, we conducted a longitudinal investigation to examine the epidemiological characteristics and antibody kinetics among 107 boosted elderly participants following the Omicron BA.5 and XBB waves. We observed that 96 participants (89.7%) were infected with Omicron BA.5, while 59 (55.1%) participants were infected with Omicron XBB. Notably, 52 participants (48.6%) experienced dual infections of both Omicron BA.5 and XBB. The proportion of symptomatic cases appeared to decrease following the XBB wave (18.6%) compared to that after the BA.5 wave (59.3%). Omicron BA.5 breakthrough infection induced lower neutralizing antibody titers against XBB.1.5, BA.2.86, and JN.1, while reinfection with Omicron XBB broadened the antibody responses against all measured Omicron subvariants and may alleviate the wild type-vaccination induced immune imprinting. Boosted vaccination type and comorbidities were the significant factors associated with antibody responses. Updated vaccines based on emerging severe acute respiratory syndrome coronavirus 2 variants are needed to control the Coronavirus Disease 2019 pandemic in the elderly.
PROBLEM TO BE SOLVED: To obtain a composition for oral cavity which exhibits excellent antimicrobial activity on causal bacteria forming supragingival and subgingival bacterial plaques and possesses high safety by including one or more kinds selected from elemol, vetiverol and patchouli alcohol as antimicrobial ingredients. SOLUTION: This composition for oral cavity is obtained by including one or more kinds selected from elemol, vetiverol and patchouli alcohol as antimicrobial ingredients preferably in a proportion of 0.0001-5 wt.% based on the whole weight of the composition for oral cavity. Besides, it is favorable to be used in combination with a bacterial plaque formation inhibitor (e.g. an extract or the like from Alpinia officinarum or the like). By this combination, the bacterial plaque formation inhibitory effect can be more increased. Further, by using in combination with a synthetic antimicrobial (e.g. a chlorohexidine salt, cetyl pyridinium chloride, benzethonium chloride, trichlorocarbanilide or the like) as an antimicrobial ingredient, the stronger antimicrobial activity can be exerted.
An ultrasound technique will be used to record the acoustic response of the fractured bone at each clinical visit until the fracture is healed. The ultrasound probe and a small hydrophone are placed on the exposed portion of the forearm on either sides of the fracture. The ultrasound intensity will be at the safe level according to the FDA regulation. Investigators will conduct the tests on the fracture and on the unaffected (contralateral) bone as the control. Typically this is at 1-, 2-, 4-, and 6- weeks following the fracture.
PET-MR scan session with a combination of anticipatory (viewing high-calorie food images) and consummatory food reward (drinking sips of chocolate milkshake). This scan session will consist of four blocks with a duration of 45 minutes each and 15 minute breaks in between. The first three blocks represent the 'control condition' (viewing neutral images and drinking sips of water) and the fourth block the 'food reward condition' (viewing high-calorie food images and drinking sips of chocolate milkshake).
Crohn's disease is one of the two main forms of idiopathic inflammatory bowel disease. The Th1-mediated inflammatory response in Crohn's disease is characterised by increased IL-18 and INF-gamma and especially TNF-alpha, which are formed by lamina propria mononuclear cells. The aim of this investigation is to determine whether a synbiotic comprised of inulin and a bifidobacterial probiotic, that we have previously shown to down-regulate TNF-alpha and other proinflammatory cytokines in the gut mucosa in ulcerative colitis patients with active disease, can colonise the bowel wall, reduce mucosal inflammation and induce remission in Crohn's disease patients with active disease, in a randomised controlled trial. Crohn's disease is associated with high mortality and incurs significant social, commercial and NHS costs. Many patients are refractile to standard treatments, which often have undesirable side effects. An inexpensive, effective and non-toxic treatment based on the synbiotic concept would contribute greatly to relieving the clinical and financial burdens of the disease.
Lantus (Insulin glargine, 100 U/mL) once daily for 16 weeks on top of mealtime insulins analogs. Basal insulin doses were individually titrated (until the end of Week 14) to reach fasting SMPG levels of 80 to 100 mg/dL, while mitigating hypoglycemia.
To efficiently conduct additional inspection and re-inspection in a radiology department.SOLUTION: A medical information system issues inspection order from an in-hospital information management system to a department information management server of a radiology department. The medical information system is provided with a proposal order creation unit, a proposal order storing unit, a report creation unit, a proposal order approval unit, and a proposal order issuing unit. The proposal order creation unit creates proposal order including setting information required in conducting additional inspection that a radiologist think necessary. The proposal order storing unit stores the proposal order and issues access information for a medical doctor to refer to the stored proposal order. The report creation unit creates an image interpretation report including the access information. The proposal order approval unit allows the medical doctor acquiring the proposal order by using the access information to select whether to approve the proposal order. The proposal order issuing unit transmits inspection instructions based on the setting information included in the approved proposal order to a medical image diagnostic device.SELECTED DRAWING: Figure 2
People living with HIV who are at least 35 years of age and who have one or more of the following conditions: hypertension, dyslipidemia, or type 2 diabetes. All genders, races and ethnicities will be included in this study. Subjects will have a telephone visit including being consented electronically and complete a demographic survey, a photography training visit and an interview visit.
Beginning 2 days prior to CD8+ T cell infusion, patients receive cyclophosphamide IV over 30 minutes. Patients undergo CD8+ T cell infusion IV over 2 hours on day 0 and receive aldesleukin SC BID on days 1-14. Beginning on day 1 about 24 hours after CD8+ T cell infusion, patients receive pembrolizumab IV over 30-60 minutes on weeks 3, 6, 12, and 15.
Local hormone therapy with estriol. The course of treatment will be of 2 weeks of daily use, and then a maintenance therapy for 12 months to prevent symptoms.
OBJECTIVE: Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy.
METHODS: We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study.
RESULTS: Six hundred and forty patients were included. Postoperative bleeding was observed in 20 cases (3.1%), and the risk factor was advanced T category. Postoperative laryngeal edema was observed in 13 cases (2.0%), and the risk factors were prior radiotherapy, advanced T stage, and concurrent neck dissection in patients with resected HPC. Dysphagia requiring nutritional support was observed in 29 cases (4.5%) at 1 month postoperatively and in 19 cases (3.0%) at 1 year postoperatively, respectively. The risk factors for long-term dysphagia were prior radiotherapy and advanced T category. Short-term risk factors for dysphagia were prior radiotherapy, advanced T category, and concurrent neck dissection, while long-term risk factors for dysphagia were only prior radiotherapy and advanced T category.
CONCLUSION: Prior radiotherapy, advanced T stage, and concurrent neck dissection increased the incidence of postoperative laryngeal edema and short-term dysphagia, but concurrent neck dissection did not affect long-term dysphagia. Such features should be considered when considering the indication for transoral surgery and postoperative management.
The present invention relates to a process for rendering real-time ultrasound images used in virtual reality. Firstly, various echo bounce coefficients are generated by ultrasonic scanning, based on a pre-defined three-dimensional (3D) organ model, for creation of images with gray-scale pixels, wherein the higher the echo bounce coefficients, the higher the relative pixel intensity value for an image, so as to obtain relative echo bounce images formed as a 3D organ is ultrasonically scanned. Secondly, the echo bounce images are treated by edge highlight enhancement for obtainment of edge enhanced images. Thirdly, a mask having graininess and diffused light is prepared to overlay the edge enhanced images for obtainment of images with diffused light and graininess. Fourthly, the images with diffused light and graininess can further overlay an upper skin texture simulated background image to form an upper skin texture image. Lastly, the upper skin texture image is treated by sectoring and cut by use of a sector mask, so as further to obtain a lifelike real-time ultrasonic scanned image that can be used in virtual reality.
OPT101 (15-mer peptide) will be provided across 2 cohorts at 1.1 (cohort 1) and 2.8 mg/kg (cohort 2) doses . On the day of administration, the product will be diluted in saline to result in 50 mL for intravenous (IV) infusion over 120 minutes.
FIELD: food industry, medicine. SUBSTANCE: raw is treated with formalin an aqueous solution to fix pigment followed by raw keeping in acidified water at pH 3.9-4.2 and temperature 48-51 C for 3-4 days. Then pectin polysaccharides are extracted with ammonium oxalate an aqueous solution at 68-70 C for 6-8 h, extract is filtered, concentrated on ultrafiltrating column with hole pores in combination with simultaneous dialysis and dried by lyophilic method. Freshly gathered plant fluorescences, for example, common tansy, Tanacetum vulgare L., containing pectin polysaccharides are used as raw source. EFFECT: improved method of preparing, increased yield of product. 3 cl, 1 tbl, 3 ex
The invention relates to a pain killer with combination of opioids and aspartic acid acceptor antagonist and a pain killing method. The pain killer is a new combination of the opioids and the aspartic acid acceptor antagonist. Through clinically acceptable slow/controlled release technology, the time difference of feeding the two drugs is realized. Therefore, with obvious pain easing effect, the pain killer is more widely applied to various clinical chronic intractable pains. The new compound pain killer is characterized by strong effect of easing pain and lasting effect. The new combination of newly used old drugs not only reduces the dosage of a single drug clinically, but also eliminates or delays the side effect that the type of drugs is tolerant clinically.
INTRODUCTION: Lipedema is a relatively common, frequently misdiagnosed, chronic condition that is often treated using liposuction when conservative therapies fail. Techniques such as traditional tumescent liposuction (TTL), power-assisted liposuction (PAL), and water-jet-assisted liposuction (WAL) are popular surgical interventions, although it is unclear how these techniques compare. This meta-analysis aimed to assess the efficacy and safety of liposuction in patients with lipedema.
METHODS: Relevant English lipedema studies published in PubMed from January 2003 to April 2023 were identified. Ten articles with post-operative outcomes and complications data were included (2 TTL, 5 PAL, 1 WAL, and 2 articles used PAL and WAL). Results were summarized using descriptive statistics, and a randomized effects model was used to evaluate heterogeneity.
RESULTS: A total of 2542 procedures in 906 patients were included. Combined outcomes for all techniques significantly improved pain, bruising, edema, tension, pressure sensitivity, cosmetic impairment, and general impairment (all P < 0.00001). TTL, PAL, and WAL led to significant improvements in pain reduction P = 0.0005), bruising, swelling, pressure sensitivity, or cosmetic impairment (all P < 0.05). However, WAL more effectively reduced tension and general impairment (all P < 0.005), but heterogeneity for these outcomes was high. Overall complication rates were low for the studies that used TTL (1.5%), PAL (4.0%), WAL (0%), and both PAL and WAL (2.3%).
CONCLUSION: Liposuction techniques, including TTL, PAL, and WAL, resulted in significant symptom improvement in patients with lipedema with a relatively low complication rate. WAL may potentially result in a more substantial reduction of tension and general impairment with fewer complications; however, only a single study performed this method of liposuction exclusively. To the best of our knowledge, this is the first meta-analysis investigating liposuction data in lipedema treatment.
Critical limb ischemia (CLI) is a peripheral arterial disease resulting from chronic inflammation of vascular systems. Recent studies have shown that inhibiting macrophage inflammation has the potential to treat CLI, and extracellular vesicles (EVs) from endothelial cells can inhibit macrophage activation. However, the limited cell-targeting capabilities and rapid clearance of EVs from the injection site limit the in vivo application of the EVs. Here, we modified endothelial EVs with platelet membranes (pM/EVs) to boost the inhibition effects on macrophage inflammation and developed an injectable alginate-based collagen composite (ACC) hydrogel for localized delivery of pM/EVs (pM/EVs@ACC) for CLI treatment. We found that pM/EVs can effectively inhibit macrophage inflammation in vitro. Furthermore, pM/EVs@ACC treatment significantly promotes the recovery of limb functions, restoring the feet' blood supply and relieving inflammation. Our findings provide compelling evidence that the pM/EVs@ACC injectable system mediating delivery of pM/EVs is a promising strategy for CLI treatment.
Multiple studies report that melanomas are innervated tumors with sensory and sympathetic fibers where these neural fibers play crucial functional roles in tumor growth and metastasis with branch specificity. Yet there is no study which reports the direct neural recording and its pattern during in-vivo progression of the cancer. We performed daily neural recordings from male and female mice bearing orthotopic metastasizing- melanomas and melanomas with low metastatic poential, derived from B16-F10 and B16-F1 cells, respectively. Further, to explore the origins of neural activity, 6-Hydroxidopamine mediated chemical sympathectomy was performed followed by daily microneurographic recordings. We also performed the daily bioluminescent imaging to track in vivo growth of primary tumors and distant metastasis to the cranial area. Our results show that metastasizing tumors display high levels of neural activity while tumors with low metastatic potential lack it indicating that the presence of neural activity is linked to the metastasizing potential of the tumors. Moreover, the neural activity is not continuous over the tumor progression and has a sex-specific temporal patterns where males have two peaks of high neural activity while females show a single peak. The neural peak activity originated in peripheral sympathetic nerves as sympathectomy completely eliminated the peak activity in both sexes. Peak activities were highly correlated with the distant metastasis in both sexes. These results show that sympathetic neural activity is crucially involved in tumor metastasis and has sex-specific role in malignancy initiation.
Sargramostim (GM-CSF) belongs to a group of growth factors termed colony-stimulating factors which support survival, clonal expansion, and differentiation of hematopoietic progenitor cells. GM-CSF induces partially committed progenitor cells to divide and differentiate in the granulocyte-macrophage pathways which include neutrophils, monocytes/macrophages and myeloid-derived dendritic cells.

GM-CSF is also capable of activating mature granulocytes and macrophages. GM-CSF is a multilineage factor and, in addition to dose-dependent effects on the myelomonocytic lineage, can promote the proliferation of megakaryocytic and erythroid progenitors. However, other factors are required to induce complete maturation in these two lineages. The various cellular responses (i.e., division, maturation, activation) are induced through GM-CSF binding to specific receptors expressed on the cell surface of target cells.

The biological activity of GM-CSF is species-specific. Consequently, in vitro studies have been performed on human cells to characterize the pharmacological activity of GM-CSF. In vitro exposure of human bone marrow cells to GM-CSF at concentrations ranging from 1-100 ng/mL results in the proliferation of hematopoietic progenitors and in the formation of pure granulocyte, pure macrophage, and mixed granulocyte macrophage colonies. Chemotactic, anti-fungal, and anti-parasitic activities of granulocytes and monocytes are increased by exposure to GM-CSF in vitro. GM-CSF increases the cytotoxicity of monocytes toward certain neoplastic cell lines and activates polymorphonuclear neutrophils to inhibit the growth of tumor cells.
The researchers will conduct a randomized cross-controlled trial involving 48 healthy adults in Hangzhou, China. These participants will be randomly assigned into two groups, each comprising 24 individuals. Each participant will undergo two separate exposures in an office setting: one exposure without any plants present, and another exposure with 34 to 38 potted plants. A washout period of at least 4 weeks will be implemented between the two exposures. Questionnaires, physical examinations and the collection of biological samples will be conducted prior to exposure and after exposure. In addition, the monitoring of negative air ion, air pollutants and noise exposure, as well as collection of environmental microbial samples, will be conducted on weekdays. Researchers will gather samples of blood, urine, nasal secretion, and exhaled breath condensate from participants.
<P>PROBLEM TO BE SOLVED: To provide a method for optimizing a prescription for a laser ablation type cornea treatment or an ophthalmologic implantation.  <P>SOLUTION: The method is an actually measured correction prescription for a present patient having a related classification element, and contains a step receiving the actually measured correction prescription using a wavefront type determination method. It is a data base of a treatment result on a plurality of previously treated patients. Each of the patient treatment results has at least one related classification element, and the database provided with the wavefront determination type correction prescription before the treatment and a visual profile after the treatment is accessed. From the treatment result in the database, the average difference between the pre-treatment prescription and the post-treatment visual profile in at least some previously treated patients having the classification element common to the present patient is calculated. In the last, the present correction prescription for the patient is adjusted so as to correspond to the calculated average difference, and an optimum prescription is formed.  <P>COPYRIGHT: (C)2003,JPO
A 60-year-old man with a high IgG4 level was found to have pancreatic tail enlargement on computed tomography (CT), and autoimmune pancreatitis (AIP) was confirmed by a histological diagnosis. He was treated with prednisolone for one year and seven months, at which point his treatment finished. Four months later, however, he had hematemesis from gastric varices. CT showed recurrence of pancreatic tail enlargement with obstruction of the splenic artery and vein and formation of collateral blood vessels to the gastric fornix. Endoscopic injection sclerotherapy was performed, and he underwent splenectomy. This case highlights the importance of paying attention to peripancreatic vascular abnormalities during follow-up of AIP patients.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, in particularly to urology, and concerns treatment of patients with chronic vesculitis. For this purpose patient's lower part is daily placed in pressure chamber and sealed, including area of hypogastrium and pelvis. During 15 minutes pressure influence is performed. During first 5 days patient is exposed to influence with reduced pressure -0.10-0.25 kg/cm2. In following 5 days - increased pressure +0.10-0.25 kg/cm2 is alternated with said reduced pressure from 3 to 5 times per session. Simultaneously with pressure influence antibiotic is drop-by-drop introduced intravenously. Additionally oxytocin at dose 5MU is introduced intramuscularly, once per day, every second day. ^ EFFECT: in short time method provides efficient eradication of pathogenic microflora from seminal vesicles and total recovery of their functions for long time. ^ 1 ex, 1 tbl
In the low need benchmark or follow-up group, survivors completed detailed baseline and 13-week assessments (about 30-40 minutes) over the telephone. A brief assessment (about 5 minutes) at week 4 over the telephone was used to assess symptoms.
Cohort1：Participants were treated with 8mg lenvatinib (weight\<60kg) or 12mg lenvatinib (weight\>60kg) orally once daily on days 1 through 21, and HAIC regimen was performed every 3 weeks. The mFOLFOX regimen was administered via hepatic artery: oxaliplatin , 85mg/m2 , from hour 0 to 2 on day1 ; leucovorin , 400mg/m2 , from hour 2 to 3 on day 1 ; fluorouracil , 400mg/m2 , bolus at hour 3 ; and 2400mg/m2 over 46 hours on days 1 and 2.
The invention discloses effective specific inhibition of rhodiola rosea extract on entry of filovirus. Effective specific inhibition of filovirus entry by rhodiola rosea extracts. The effective specific inhibition of filovirus entry by ellagic acid in rhodiola rosea extracts. Filoviruses include ebola virus and marburg virus. The beneficial effects of the invention are that experiments show that the rhodiola rosea extract shows effective specific inhibition against entry of filovirus and has little cytotoxicity. In addition, ellagic acid was identified as the most effective component in rhodiola rosea extracts.
Liver fibrosis, characterized by excessive extracellular matrix (ECM) deposition, can progress to cirrhosis and increases the risk of liver cancer. Hepatic stellate cells (HSCs) play a pivotal role in fibrosis progression, transitioning from a quiescent to activated state upon liver injury, wherein they proliferate, migrate, and produce ECM. Calcium signaling, involving the inositol 1,4,5-trisphosphate receptor (IP3R), regulates HSC activation. This study investigated the efficacy of a novel IP3R inhibitor, desmethylxestospongin B (dmXeB), in preventing HSC activation. Freshly isolated rat HSCs were activated in vitro in the presence of varying dmXeB concentrations. The dmXeB effectively inhibited HSC proliferation, migration, and expression of fibrosis markers without toxicity to the primary rat hepatocytes or human liver organoids. Furthermore, dmXeB preserved the quiescent phenotype of HSCs marked by retained vitamin A storage. Mechanistically, dmXeB suppressed mitochondrial respiration in activated HSCs while enhancing glycolytic activity. Notably, methyl pyruvate, dimethyl α-ketoglutarate, and nucleoside supplementation all individually restored HSC proliferation despite dmXeB treatment. Overall, dmXeB demonstrates promising anti-fibrotic effects by inhibiting HSC activation via IP3R antagonism without adverse effects on other liver cells. These findings highlight dmXeB as a potential therapeutic agent for liver fibrosis treatment, offering a targeted approach to mitigate liver fibrosis progression and its associated complications.