anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cannabinoid for use in prevention or treatment of a symptom of an autism spectrum disorder by preventing or reducing gastrointestinal inflammation, gastrointestinal hyperpermeability and/or colonic muscle thinning. The cannabinoid is administered to a subject who has or suspected of having gastrointestinal hyperpermeability, gastrointestinal inflammation, and/or colonic thinning. The symptom of autism may be a behavioural symptom and/or a gastrointestinal symptom. The subject may have been diagnosed with Crohn’s disease, coeliac disease, ulcerative colitis, type I diabetes, arthritis including spondylarthritis and psoriatic arthritis, or inflammation, particularly gastrointestinal inflammation. Also disclosed is a cannabinoid for use in the prevention, treatment, or reduction of gastrointestinal hyperpermeability or gastrointestinal inflammation. The cannabinoid may be cannabidiol (CBD), tetrahydrocannabinol (THC) or a combination thereof. The cannabinoid may be suitable for oral administration, e.g. in the form of a pharmaceutical or nutritional composition. The subject may be human and may be a child. Also disclosed is a dosage form of the cannabinoid comprising 0.1-20 mg/kg body weight of CBD and/or 0.05-6 mg/kg body weight of THC.
Discoidin domain receptor 1 (DDR1) is a collagen receptor with tyrosine kinase activity, and its expression is enhanced in various disease conditions. Although previous research suggests that DDR1 contributes to renal disease progression, DDR1 inhibitors for renal fibrosis have yet to be developed. In this study, we used unilateral ureteral obstruction (UUO) mice to investigate whether CH6824025, a strong and selective DDR1 phosphorylation inhibitor, can improve renal fibrosis. Furthermore, we performed 10x Visium spatial transcriptomics (ST) analysis on the kidney. CH6824025 suppressed the phosphorylation of DDR1 in the kidney, and the amount of hydroxyproline, the Sirius red- and the F4/80-positive area, and the mRNA expression of fibrosis and inflammation-related genes in the kidney were significantly decreased. 10x Visium ST analysis suggested that DDR1 is mainly expressed in distal nephrons under normal conditions but its expression appears to increase in the injured proximal tubules in UUO mice. Comparing mRNA expression in DDR1-positive spots in the Vehicle and the CH6824025 group, oxidative phosphorylation and mitochondrial dysfunction might be improved, and pathways involved in fibrosis tended to be inhibited in the CH6824025 administration group. Downstream analysis would suggest that mRNA expression changes in the CH6824025 group contribute to the inhibition of cell movement. Taken together, our findings suggest that CH6824025 inhibited kidney fibrosis in UUO mice, which might be due to the inhibition of the migration of inflammatory cells to the injury site and the reduction of inflammation. DDR1 inhibitors are expected to be a promising treatment of renal fibrosis. SIGNIFICANCE STATEMENT: The novel discoidin domain receptor 1 inhibitor CH6824025 could ameliorate fibrosis and inflammation in unilateral ureteral obstruction (UUO) mice. CH6824025 would inhibit cell motility (e.g., migration) that prevents the progression of fibrosis and improves mitochondrial function in UUO mice. CH6824025 could provide a significant benefit to patients with kidney fibrosis.
A smart carry case which is effectively a portable GPS-enabled, AED monitoring system that is capable of monitoring an AED (as well as itself) and reporting back the presence, function and location of the AED to a remote host. Also disclosed is street furniture that is configured to retain, continuously monitor, and dispense an AED and communicate to a remote host (i.e., a control room). The street furniture is preferably configured such that a user presses the intercom button. In response, the street furniture contacts the control room. The control room, in turn, sends a signal to the street furniture causing the compartment to unlock so the AED can be removed and used in a rescue. The street furniture is configured to continuously monitor the AED and ensure it is functional, using a device such as has been described hereinabove. If the AED is used, an ambulance is deployed to the location. The AED that is retained in the compartment may be a smart carry case. As such, the presence, function, and location of the AED can be continuously monitored.
The invention provides a moxa stick for treating the cervical vertigo. The moxa stick is prepared by main materials and ingredients. The main materials are composed of the following raw materials in weight part: 1-3 parts of grass-leaved sweetflag rhizome, 1-3 parts of Chinese ligusticum rhizome, 1-3 parts of dahurian angelica roots, 1-3 parts of santal, 1-3 parts of chast tree berry, and 0.5-1.5 parts of mint. The weight ratio of the main materials to the ingredients is (7.5-9.5):(0.5-2.5). The moxa stick effectively treats the cervical vertigo and shortens the vertigo period, which is small in side effect. By means of the moxa stick, the neck diseases of patients are treated based on the moxibustion therapy, and the effects of simple treatment technique, low treatment risk and substantial curative effect are realized. In this way, the problems in the prior art that the western medicine treatment is high in surgery cost, large in patient pain and poor in clinical effect can be solved. Meanwhile, the problem that the Chinese traditional treatment is high in requirements on treatment techniques during the massage and traction process is also solved.
Gastrodin (GAS), a bioactive compound derived from the orchid plant Gastrodia elata, exhibits numerous pharmacological effects. However, its effect on sleep deprivation (SD)-induced cardiac injury and the mechanisms are unknown. This study established SD mice model using a modified multiple platform water method and induced ferroptosis model in H9c2 cells using Erastin. The heart rate of mice was measured, and myocardial and mitochondrial structures were visualized using hematoxylin and eosin (H&E) staining and transmission electron microscopy (TEM). Myocardial injury, oxidative stress indicators, and Fe2+ levels were detected by the kit method. The reactive oxygen species (ROS) levels were detected by immunofluorescence, and SIRT6 and ferroptosis-associated protein expression levels were detected by Western blot. Reduced heart rate and abnormalities in myocardial tissue and mitochondrial structure were ameliorated in the SD group of mice after GAS treatment. GAS treatment reduced ROS levels in Erastin-induced H9c2 cells. GAS treatment reduced atrial natriuretic peptide (ANP), creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MAD), and Fe2+ levels, and increased superoxide dismutase (SOD) and glutathione (GSH) levels in the SD and Erastin groups. Western blot showed that GAS treatment increased the expression of sirtuin 6 (SIRT6), solute carrier family 7 member 11 (SLC7A11), and glutathione peroxidase 4 (GPX4) and decreased the expression of P53 in SD and Erastin groups. The SIRT6 inhibitor OSS_128167 (OSS) reversed GAS treatment of Erastin-induced ferroptosis in H9c2 cells. These observations propose that GAS prevents myocardial injury in sleep-deprived mice by suppressing ferroptosis through SIRT6.
SWEDEHEART is a Swedish national registry consisting of several sub registries in which patients with acute coronary syndrome are prospectively registered. Patient characteristics, hospital treatments, drug treatments at discharge, and outcome for patients consecutively included and treated at all Swedish coronary care units are collected in this registry.SEPHIA is a sub registry collecting data on secondary prevention and cardiac rehabilitation. Follow-up are registered at six to ten weeks and at 12 to14 months post MI by office visits or phone. Around 80 % of all Swedish acute myocardial infarction (AMI) patients below the age of 75 years are included in this register.

In this study, a cohort of 5 904 (74% men) registered in the SEPHIA registry and who had one year follow-up during 2013, will be included. Data are aggregated and delivered from the SWEDEHEART/SEPHIA national registry. All patients were informed about their participation in the registry, the follow-up, and their right to decline participation. No written consent was obtained
Our previous study demonstrated neuroprotective and therapeutic effects of a standardized flavonoid extract from leaves of Diospyros kaki L.f. (DK) on middle cerebral artery occlusion-and-reperfusion (MCAO/R)-induced brain injury and its underlying mechanisms. This study aimed to clarify flavonoid components responsible for the effects of DK using in vitro and in vivo transient brain ischemic models. Organotypic hippocampal slice cultures (OHSCs) subjected to oxygen- and glucose-deprivation (OGD) were performed to evaluate in vitro neuroprotective activity of DK extract and nine isolated flavonoid components. MCAO/R mice were employed to elucidate in vivo neuroprotective effects of the flavonoid component that exhibited the most potent neuroprotective effect in OHSCs. DK extract and seven flavonoids [quercetin, isoquercetin, hyperoside, quercetin-3-O-(2″-O-galloyl-β-D-galactopyranoside), kaempferol, astragalin, and kaempferol-3-O-(2″-O-galloyl-β-D-glucopyranoside) compound (9)] attenuated OGD-induced neuronal cell damage and compound (9) possessed the most potent neuroprotective activity in OHSCs. The MCAO/R mice showed cerebral infarction, massive weight loss, characteristic neurological symptoms, and deterioration of neuronal cells in the brain. Compound (9) and a reference drugs, edaravone, significantly attenuated these physical and neurological impairments. Compound (9) mitigated the blood-brain barrier dysfunction and the change of glutathione and malondialdehyde content in the MCAO mouse brain. Edaravone suppressed the oxidative stress but did not significantly affect the blood-brain barrier permeability. The present results indicated that compound (9) is a flavonoid constituent of DK with a potent neuroprotective activity against transient ischemia-induced brain damage and this action, at least in part, via preservation of blood-brain barrier integrity and suppression of oxidative stress caused by ischemic insult.
Heavy episodic drinking (HED) rates remains at unacceptably high levels on college campuses. Researchers on parent-based interventions (PBIs) has revealed promising results. but studies have generally failed to reduce HED in college students. FITSTART was developed to address two limitations of traditional PBIs that may contribute to the lack of the aforementioned effects: (I) they are purely informational and (II) they typically lack a motivational component to capture parents' attention and increase motivation to proactively engage their students. Pilot work has revealed that parents display predictable normative misperceptions (e.g., overestimate how approving other parents are of drinking and underestimate how often other parents engage with their students about drinking). As predicted by social norms theory, these false beliefs are associated with parents displaying more approving attitudes themselves and communicating less frequently. Correcting these norms should motivate parents to proactively engage their child in risk-reducing directions. FITSTART combined a social norms feedback component with informational material ("tips") characteristic of a traditional PBI in an in-person interactive format and successfully reduced HED. While the effects on weekly drinking, HED, and non-drinker alcohol use initiation were robust 1-month into college (3-months post intervention). FITSTART's usefulness as a universal approach is limited because it was delivered to parent groups on-campus during pre-college orientation sessions and many colleges do not hold summer orientations and/or lack the resources to administer FITSTART. To address this limitation, a web-based platform (or app) was developed using a new cutting-edge modality that draws from the computer science literature on virtual co-presence to create an online environment that mimics the effects of a live group social norms session.

The current pilot study seeks to evaluate the efficacy of the FITSTART+ PBI in a randomized control trial (RCT) by evaluating changes in incoming first-year students' alcohol use and related negative consequences during the transition into college. The sample will consist of traditional first year students (17-20 years of age) from Loyola Marymount University who completed consent and the baseline survey, and whose parents downloaded and registered for the FITSTART+ intervention or control app. Parents will be invited to download the intervention/control app two weeks prior to their student's arrival on campus in the fall (beginning of August). To examine the short- and long-term effects of the intervention, students will complete a baseline survey at the end of July (pre- matriculation) and two follow-up surveys, approximately 1 month (October) and 6 months (April) after the students arrive on campus in the spring.
Based on a power analysis a total population of 100 children (four school classes) will be invited to participate in a 10-day protocol. The children will be randomly allocated, within their cluster (classes) and stratified for gender and soccer level, to one of 3 intervention groups. The groups consist of: A small-sides soccer game group (SSG), a walking soccer group (WSG) and a rest group watching soccer on TV (RES). At day 1 the children will complete a screening of their physical characteristics (height, weight, fat percentages, lean muscle mass and fitness status). On day 2 the children will complete a screening and a familiarization to the cognitive tasks used (cognitive performance and long-term memory) and the brain activity measuring devices (transportable EEG systems). On day 3 the children will complete the interventions, which first consist a long-term memory task, where the children will be asked to remember forty different pictures. Immediately after exposure to the forty pictures, the children will participate in 2 x 10 minutes of their respective interventions with 5 minutes break in between. During the break, the children will complete a short questionnaire to address their flow. Furthermore, during the intervention they will be equipped with heart rate monitors to quantify the physical demands of the intervention. Immediately after completing the 2 x 10 minutes interventions the children will be equipped with a transportable EEG system, and undergo a cognitive test (the Flanker task) to address their cognitive performance. The EEG recordings are used to measure the P3 amplitude and latency, biomarkers for cognitive performance. While equipping the children with the EEG system, the children will complete questionnaires about their participation. At day 10 the children will try to remember as many pictures of the forty pictures as possible to address the effect of the interventions on their long-term memory.
Disclosed herein are novel amisulpride derivatives and pharmaceutical compositions thereof. The amisulpride derivatives disclosed herein or pharmaceutical compositions thereof may have better membrane permeability than amisulpride. Amisulpride derivatives disclosed herein, or pharmaceutical compositions thereof, may be used alone or in combination with other CNS active agents to antagonize dopamine and/or serotonin (e.g. 5-HT2 a) and/or alpha 2 receptors in a subject. The amisulpride derivatives disclosed herein, or pharmaceutical compositions thereof, may be used alone or in combination with other CNS active agents to treat one or more conditions responsive to modulation of dopamine and/or serotonin (e.g. 5-HT2 a) and/or alpha 2 receptors in a subject. The amisulpride derivatives disclosed herein, or pharmaceutical compositions thereof, may be used alone or in combination with other CNS active agents to treat one or more disorders associated with abnormal dopamine and/or serotonin levels in the brain.
The aim of this study is to adapt the Sedentary Behavior Questionnaire (SBQ) into the culture of Turkish and to work on the reliability and validity of it in healthy individuals between the ages of 18-64. Original form has nine questions but Spanish version of it had eleven questions so the investigators will translate Spanish version of SBQ. At first step by using a forward-backward translation method, a translation and adaptation process will be performed. At second step the validation process will be performed in a total of 200 healthy subjects aged between 18-64 years. Subjects will fill sociodemographic information form, International Physical Activity Questionnaire Short Form, and SBQ Turkish version ( at baseline and after seven days). Cronbach's alpha values, confirmatory factor analysis (CFA) will be evaluated for the reliability, construct and convergent validity.
Among individuals with pancreatic ductal adenocarcinoma (PDAC) 5-10% have a pathogenic germline variant (PGV) in a PDAC susceptibility gene. Guidelines recommend genetic testing among all individuals with PDAC. Additionally, at-risk relatives of PDAC patients benefit from their own genetic education, risk assessment, and testing. Multigene panel testing (MGPT) can identify individuals with inherited cancer risk who can benefit from early cancer surveillance and risk reduction strategies. This manuscript discusses various healthcare delivery models for MGPT including traditional in-person genetic counseling, novel integrated in-person infrastructures, telemedicine genetics care via telephone- or video-visits and direct-to-consumer testing. Barriers and facilitators to care on the individual, provider, and system level are also outlined including specific considerations for historically marginalized communities.
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to conjugates of interferon of the formula (I):   where R and R 1  mean independently each of other lower alkyl; X means NH or O; n and h 1  mean whole numbers and their sum is from 600 to 1500 Da; and mean molecular mass of polyethylene glycol links in this conjugate is from 26 000 Da to 66 000 Da. Invention relates to also a method of synthesis of conjugate polyethylene glycol/d-IFN showing antiproliferative activity and to method of treatment and prophylaxis of immunomodulatory diseases. Conjugate polyethylene glycol/d-IFN shows the prolonged period of half-life in circulation system and plasma time, decreased immunogenicity and clearance and enhanced antiproliferative activity that is accompanied with decreased antiviral activity. EFFECT: valuable medicinal properties of conjugates. 14 cl, 6 dwg, 4 tbl, 6 ex
PROBLEM TO BE SOLVED: To obtain a new compound A-76,356 produced by a bacterium belonging to the genus Micromohospora separated from soil, effective against gram positive and gram negative bacteria. SOLUTION: This compound A-76,356 is shown by the formula, its salt or a compound in which its carboxyl group is protected. The compound of the formula is obtained by culturing a bacterium belonging to the genus Micromonospora, capable of producing the compound A-76,356 and collecting the compound A-76,356 from the culture solution. Micromonospora sp. SANK 62,395 strain (FERM BP-5,287) is the optimum as the bacterium belonging to the genus Micromonospora. The compound A-76,356 shows antimicrobial actions and is useful as a preventive and a therapeutic agent for various bacterial infectious diseases. Na salt, K salt, Ca salt, etc., may be cited as the salt of the compound of the formula. The compound includes various stereoisomers, solvates and further so-called prodrugs which are metabolized in vivo and converted into the compound A-76,356.
BACKGROUND: Opioid analgesic use before total hip or knee arthroplasty has been associated with worse postoperative outcomes. This pilot study aimed to examine the feasibility of a telehealth-based pharmacist-partnered opioid tapering intervention before elective primary hip or knee arthroplasty and its potential effectiveness compared with usual care.
METHODS: This study was conducted at seven hospitals in New South Wales, Australia. Eligible patients were those aged ≥ 18 years, scheduled to undergo primary hip or knee arthroplasty for osteoarthritis and taking opioid analgesics pre-operatively. The intervention group participated in an opioid tapering telehealth service, a partnership between a pharmacist and general practitioner, for 3 months pre-operatively up to the day of surgery, while the control group received usual care. The primary outcomes of the study were to investigate the feasibility of the intervention (i.e. adherence to treatment) and potential effectiveness in decreasing baseline daily opioid dose by > 50% before surgery.
RESULTS: Between December 2021 and June 2023, 70 patients were recruited and assigned randomly to the intervention group (n = 35) or control group (n = 35). Baseline characteristics were similar between groups. Thirty patients in each group completed their allocated treatment. All patients allocated to the intervention group completed at least one appointment with a pharmacist, with the median (IQR [range]) being 2 (1-4 [1-6]) appointments. The number of patients who successfully decreased their baseline daily opioid dose by ≥ 50% before surgery was 27/30 in the intervention group compared with 5/30 in the usual care group (p < 0.001).
CONCLUSIONS: The findings of this pilot study support the feasibility of a telehealth-delivered, pharmacist-partnered opioid tapering service for patients scheduled for primary hip or knee arthroplasty. A broader multicentre study to examine the effectiveness of this intervention on clinical outcomes is warranted.
This study aims to determine whether certain front-of-package food labeling systems improve the healthfulness of consumers' grocery selections. The survey research company Cloud Research will recruit a sample of approximately 5,610 US adults ages 18+ who read and speak English and who are their households' primary grocery shopper.

Participants will complete a between-subjects online randomized experiment. They will be randomized to 1 of 6 front-of-package labeling systems: 1) positive labels, 2) spectrum labels, 3) Food and Drug Administration (FDA) high in labels, 4) FDA traffic light labels, 5) FDA high in labels plus positive labels, or 6) FDA traffic light labels plus positive labels. Participants will complete a shopping task in a naturalistic online grocery store. Participants will be instructed to shop as they usually would for items in the following categories: non-alcoholic beverages (e.g., juice, coffee, tea, soda, sports drinks, water), breads and baked goods, breakfast cereals, soups, boxed and frozen meals, and snacks (e.g., chips, crackers, nuts, applesauce, dried fruit). They will be given a budget based on average spending in these categories in a large supermarket chain. The store will record participants' selections. After completing the shopping task, participants will complete an online survey.