anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The writer will ask the participant about their interests and experiences in writing or storytelling. The following options are offered; introduction to journaling, storytelling or writing exercises with prompts to get started, interactive writing or storytelling activities. For participants who are unable to write or prefer not to, the writer can scribe their words on a laptop and print them out. The duration of the intervention will be determined by participant interest and tolerance, but not to exceed 60 minutes. For follow-up sessions, participants will be supplied with a journal.
BACKGROUND: The effectiveness of the quadratus lumborum block (QLB) for postoperative pain management depends on the injection pathway used. There is limited research on the block area produced by intramuscular injection of local anesthesia in the quadratus lumborum muscle. This study aimed to determine the cutaneous sensory blockade area produced by an intramuscular quadratus lumborum block (QLBi) at the L2 level.
METHODS: Twenty patients aged 18-60 years with ASA grade I-II and a BMI of 18-30 kg/m2 who were scheduled for open inguinal hernia repair with mesh underwent ultrasound-guided QLBi injection of 20 ml of 0.5% ropivacaine. The cutaneous sensory blockade area was measured by applying a cold stimulus 1 h after the block and then measured every hour after surgery until the sensation returned to normal. The duration of a blockade is defined as the time it takes for all affected areas to fully regain normal sensation following a blockade. Pain scores (numeric rating scale, NRS) were recorded at 2, 4, 8, 12, and 24 h after surgery. Adverse reactions to QLBi were recorded 24 h after surgery.
RESULTS: All 20 patients had reduced or lost cold sensation areas. The greatest extent of cold sensation reduction occurred at T7 (10%), and the least amount of cold sensation reduction occurred at L3 (10%). The block level covered T8 (20%), T9 (30%), T10 (45%), T11 (90%), T12 (95%), L1 (100%), and L2 (15%). Eighteen patients experienced areas of sensory loss, with the highest range at T11 and the lowest at L2. The duration of the blockade was 8.9 ± 3.8 h, with a maximum of 24 h and a minimum of 5 h. One patient experienced quadriceps weakness after surgery.
CONCLUSION: Quadratus lumborum block of intramuscular pathway can produce effective cutaneous sensory blockade, which can be used for postoperative analgesia of indirect inguinal hernia operation, and may also be beneficial to analgesia of other lower abdominal operations. However, the best method needs further confirmation to determine specific anesthesia methods for various operations.
CHINESE CLINICAL TRIAL REGISTRY: June 2, 2018; ChiCTR1800016457.
Cutaneous sclerosis, a highly morbid subtype of chronic graft-versus-host disease (GVHD), demonstrates limited treatment response under current National Institutes of Health (NIH) response measures. We explored novel sclerosis-specific response measures using Chronic GVHD Consortium data. A training cohort included patients with cutaneous sclerosis from a randomized trial of imatinib vs rituximab and a consortium observational study. The validation cohort was a different consortium observational study. Clinician-reported measures (baseline and baseline to 6-month change) were examined for association with 6-month clinician-reported response. Patient-reported measures (baseline and baseline to 6-month change) were studied for association with 6-month patient-reported response. A total of 347 patients were included (training 183 and validation 164). Although multiple skin and joint measures were associated with clinician-reported response on univariate analysis, patient range of motion (PROM) total score, PROM total score change, and NIH 0 to 3 skin change were retained in the final multivariate model (area under the receiver operating characteristic curve [AUC], 0.83 training and 0.75 validation). Similarly, many patient-reported measures were associated, but final multivariate analysis retained the human activity profile adjusted activity score (AAS), 36 item short form health survey (SF36) vitality change, Lee symptom scale (LSS) skin, and LSS skin change in the model (AUC, 0.86 training and 0.75 validation). We identified which sclerosis measures have the greatest association with 6-month clinician- and patient-reported treatment responses, a previously unstudied area. However, given the observed performance in the validation cohorts, we conclude that further work is needed. Novel response measures may be needed to optimally assess treatment response in cutaneous sclerosis.
Subjects have never been vaccinated with a Hepatitis B vaccine. Subjects are vaccinated with Hepatitis B vaccine HBAI20 at day 0 and 30, and Hepatitis B vaccine HBVaxPro-10ug at day 180.
Complete isolation was performed using a rubber dam and saliva ejector. Patients received topical anesthesia before the clamp was placed. Dental caries was excavated using the Er:YAG laser with a wavelength of 2940nm according to the manufacturer's instructions until visual inspection showed that the carious lesions have been thoroughly removed. If the patient experienced pain and requested local anaesthesia, the procedure was stopped, local anaesthesia has been applied, and then the procedure has resumed. Cavities were restored using the Clearfil Universal Bond Quick system in total each mode; 37% phosphoric acid was used, then the Clearfil Universal Bond system was applied, light cured for 90 seconds, after which composite resin was applied (3M Filtek TM Z350 XT Universal Restorative Composite (3M ESPE) according to the manufacturer's instructions.
Corneal ulceration is a leading cause of visual impairment globally, with a disproportionate burden in developing countries. Corneal opacity after ulceration is responsible for a significant proportion of blinding eye disease in Africa and Asia. While antimicrobial treatment is generally effective in eradicating infection, "successful" treatment is often associated with a poor visual outcome. The scarring that accompanies the resolution of infection leaves many eyes blind. It has been difficult to discern differences between different antimicrobials in a randomized controlled trial (RCT). In fact, only a single RCT with more than 50 subjects has found any significant difference between ulcer treatments. Thus, prevention of corneal ulceration may be our best opportunity to reduce morbidity associated with corneal ulceration.

Several non-randomized prevention studies in Nepal, Myanmar, and Bhutan have suggested that antibiotic ointment applied promptly after a corneal abrasion could dramatically lower the incidence of ulcers, relative to neighboring or historic controls. In Madurai, South India, a clinical trial demonstrated that abrasions randomized to topical antibacterial and antifungal prophylaxis were not significantly less likely to develop fungal ulcers than those randomized to antibacterial ointment alone, even though the region had a high incidence of fungal infection. This same trial also found that the incidence of ulcers in villages outside the prophylaxis program was far higher; these control villages were neighboring but not randomized, and it is possible that they were in some way different from the villages included in the program.

VIEW was designed to determine whether we can prevent corneal ulcers on a large scale. VIEW is a community-randomized trial comparing villages randomized to receive an intervention consisting of a trained community health volunteer providing antimicrobial ointment after a corneal abrasion to control villages receiving no additional intervention. The primary outcome of corneal ulcer will be measured by baseline and annual population-based census performed in both intervention and control villages by masked examiners from baseline to 36 months. The examiners will photograph corneas of all residents who are suspected of having a corneal ulcer, with photographs later read by masked examiners. Each resident in the village will be examined for evidence of a corneal opacity and asked about their ocular history. In villages randomized to intervention, the trained community health volunteers will actively promote their services through regular meetings with local women's groups by encouraging residents to notify the village eye health worker within 24 hours of ocular trauma. In control villages, abrasions and ulcers will be treated if they present to a clinic or are found during the annual monitoring visits, but active promotion of corneal abrasion care will not be offered.
Participants will receive 0.5mg/kg of Ketamine orally with an equivalent quantity of placebo via an intramuscular injection on Day 0/Visit 4 and receive Meaning and Purpose (MaP) therapy 4 times, twice before (between days -13 and -1) ketamine administration, and twice afterward on days 3 (+/- 2 days) and 11 (+/- 3 days). The duration of treatment for ketamine plus MaP (K-MaP) therapy is approximately up to 28 days. Participants will be followed up to 35 days (+/-2 days) after ketamine administration.
The preterm birth is considered as a main problem in the modern obstetrics, being the responsible of greatest of 50% neonatal morbimortality and heavy costs. Despite the significant medical advances, the rate of prematurity has not declined over the past 40 years and even continues to rise in the developed countries. In order to decrease the prematurity is necessary that two premises: to identify the pregnant women at risk of preterm birth, and dispose of useful measures aimed at prolonging the pregnancy and therefore avoid preterm delivery. Since 1990, many published articles describe the sonographic measurement of the cervix from the week 16 as method of population screening to detect women at risk. Several studies provide evidence about an inverse relationship between the cervical length and the risk of preterm delivery. For this reason, if there is an effective intervention for patients with cervix short (about \< 25mm), made this measure in the middle of the second term, the investigators could reduce the prematurity. Regarding possible therapeutic strategies, recent published data demonstrate the effective of vaginal progesterone and cervical pessary in this population. However, both treatments have never been compared and none of the two strategies are indicated in this population. Therefore it results necessary to compare both treatments in order to establish clinical recommendations. The investigators propose a clinical trial to compare two accepted strategies: administration of progesterone (vaginally) or the placement of vaginal pessaries in order to reduce the premature birth (34 weeks and earlier) rate in the population of pregnant women at risk for premature birth, which will be identified by ultrasound during the second trimester of their pregnancy.
PURPOSE:To provide the titled compsn. capable of retaining an invariable medicinal effect or fragrance over a long period of time, by melt-mixing a thermoplastic resin compsn. contg. a drug with a thermoplastic resin non-compatible with the drug. CONSTITUTION:A thermoplastic resin (a) e.g. ethylene/vinyl acetate copolymer) compatible with a drug (b), such as perfume, vaporizable rust inhibitor or insecticide, is impregnated with or melt-mixed with the reagent (b) to obtain a resin compsn. (A). Compsn. A is melt-mixed with other thermoplastic resin (B) (e.g. crystalline PP) compatible with component (a), but incompatible with component (b). EFFECT:The loss of the drug is reduced and the effect of the drug and its persistence can be controlled. USE:Food packaging, protection of fruit and clothing, packing material for machines, etc.
The pleuromutiline is an antibiotic of expressed antibacterial effect against microplasmas and other bacteria, its semi-synthetic derivative thiamuline being particularly effective. By the method, a strain producer Clitopilus pinsitus, registered in NBIMCC under No. 3910, cultivates in deep, in aerobic conditions on nutrients, containing assimilation sources of carbon, organic nitrogen and mineral salts in wt. %: glucose from 3 to 15, proflo 0.3-0.6, maize extract from 3 to 5, soya bean oil 0.3-1.5. magnesium sulphate 0.01-0.05 and calcium carbonate 0.1-0.5. The fermentation process runs at temperatures ranging from 25 to 30 degrees C, pressure 0.5-0.8 bar and pH 6.0-8.0. The mutant used has increased antibiotic titre in the cultural medium and accumulates relatively small side products in the process of fermentation. 1 claim
The invention discloses a traditional Chinese medicine used for treating hypertensive diseases, and a preparation method thereof. The medicine is prepared from raw oyster, raw rehmannia root, lobed kudzuvine root, medicinal cyathula officinalis root, radix salviae miltiorrhizae, white peony root, Chinese wolfberry root-bark, and Szechwan lovage rhizome. During preparation, the raw oyster is decocted for 30min, and the rest medicine materials are soaked for 30min; the medicine materials are decocted on fire; after the medicine materials are boiling, the materials are decocted for half an hour; each preparation is decocted 2-3 times, and obtained medicine liquids are combined, such that a decoction of the medicine provided by the invention is obtained. If a patient suffers from severe dizziness and insomnia, common selfheal spike, tall gastrodia rhizome, raw dragon's bone, and tuckahoe can be added into the medicine. If arrhythmias and heart premature beat occurs, pilose asiabell root, creeping liriope, and tea root can be added into the medicine. If lumbar pain occurs, eucommia bark and Chinese taxillus herb can be added to the medicine. Other medicine materials such as Asiatic plantain herb, medlar, and motherwort can also provide an antihypertensive effect. The medicine provided by the invention has a comprehensive treatment effect.
Patients will be screened over the telephone. Information will be gathered from the mental health treatment team and the patient. Most patients who come to this study have had an inadequate or insufficient improvement with clozapine. Upon arrival at the NYS Psychiatric Institute, they review and sign consent to make sure the details of the research study are understood. Comprehensive assessments are conducted, including neurocognitive testing, prior to treatment onset. The treatment is randomized so patients will either receive IV ceftriaxone or IV placebo. Treatment is given Monday through Friday to enable the patient to have weekends off without a plastic tube (angiocath) in the vein of the arm. If after 6 weeks the patient's symptoms are not at least mildly improved, then the treatment will be stopped. If however there are signs of improvement, the treatment will be continued another 2 weeks. If at the end of the "double-blind" part of the study a patient learns he/she received placebo and wishes to be given ceftriaxone, we will provide 4 weeks of ceftriaxone for those patients. The inpatient unit is located in the NYS Psychiatric Institute which is adjacent to the Columbia Medical Center in northern Manhattan. Our new building for the NYS Psychiatric Institute is about 10 years old so the inpatient unit is quite attractive with beautiful views of the Hudson River and the Palisades. There is no financial cost for the inpatient stay nor is there a financial cost for participating in this study.

Patients or family members wishing to learn more about this research study should call 212-543-6510 for more information or call Dr. Fallon directly at 212-543-5487.
Patients will receive anesthesia induction using 5 cmH20 of CPAP until the moment of intubation. After induction patients will receive the same protective ventilation than the control group. A lung recruitment maneuver will be applied if these patients present atelectasis during surgery. At the end of surgery, patients will be extubated under the modality of CPAP with 5 cmH20. Lung ultrasound examinations will be performed at different times-points: before anesthesia induction, during surgery, at the end of surgery and before extubation, and after extubation.
PURPOSE:The titled perfume, prepared by encapsulating a perfume dissolved in polyethylene glycol or polypropylene glycol in a capsule made of gelatin containing a certain kind of glucide and capable of becoming an aqueous solution simply by pouring in water at need. CONSTITUTION:A perfume prepared by encapsulating a perfume dissolved in a compatibilizing agent in a capsule made of gelatin containing a glucide. Polyethylene glycol having 250-450 molecular weight or polypropylene glycol having 200-900 molecular weight is used as the compatibilizing agent, and a glucide selected from neutral glucan, having 80,000-350,000 average molecular weight, and prepared by polymerizing hexitol, e.g. sorbitol, and maltotriose with 1,6- glucoside bonds is used as the glucide. with gelatin at a weight ratio of 70:30. Both the gelatin capsule and solubilized perfume will be easily dissolved in water, and a toilet water is instantly obtained.
PURPOSE:To obtain the title fungi at a high proliferation rate by dispersing fungi produced by incubating specific microorganisms in an aqueous solution containing an organic compound as substrate and a water-soluble selenium compound. CONSTITUTION:Firstly, yeast such as beer yeast, bacteria such as lactobacillus, or unicellular algae such as Chlorella is, as the case may be, incubated and proliferated. The resultant fungi collected is washed with e.g. water and prepared to a fungal concentration at a level not lower than the biological space. The fungi is then dispersed in an aqueous solution containing (A) an organic compound as substrate for polymerizing selenium (e.g. saccharide such as glucose and/or amino acid such as leucine and (B) a water-soluble selenium compound such as selenious acid, and reacted into polymerized selenium which is then accumulated in the fungi. After reaction, the fungi is collected through e.g. centrifugation and washed with water, thus giving the objective fungi at a high proliferation rate. The present fungi can be concentrated; therefore, the waste liquor therefrom can be reduced.
BACKGROUND & AIMS: Duchenne muscular dystrophy (DMD) involves muscle fragility, sarcolemma instability, and chronic inflammation. This study aims to identify the inflammatory profile of DMD patients and evaluate associations between clinical and nutritional variables.
METHODS: We performed a cross-sectional study nested in a cohort to obtain sociodemographics, illness time, use of medications, and supplement data through interviews and the patient's medical records. Then, we assessed the relationships between illness time, cytokine levels, and nutritional status.
RESULTS: Forty-four male participants, aged 4.3-24.2 years, were evaluated. Concerning nutritional status, 18 participants were eutrophic. The fat mass increased and the lean mass decreased from the beginning of the first signs of DMD. Cytokines levels in DMD patients, even under corticosteroids therapy, are higher than values described in the literature on healthy subjects. The regression models demonstrated that illness time and BMI/A z-scores are associated with higher values of interleukin-6.
CONCLUSIONS: A persistent inflammatory profile was observed in the patients evaluated. The data suggest that maintaining adequate nutritional status and body composition is important for determining the inflammation presented by individuals with DMD.
It is intended to provide a tissue for transplantation being free from troubles accompanying transplantation such as calcification. It is also intended to provide a membrane for preventing adhesion by which adhesion caused by a surgical operation or treatment can be prevented. It is found out that when a biocompatible polymer is added to an untreated tissue and then the tissue is exposed to Ϝ-ray irradiation, the tissue is unexpectedly strengthened and calcification is prevented, thereby solving the above problems. Although there has been recognized that decellularization is the key factor in preventing a tissue with a biological origin from calcification, it is indicated that Ϝ-ray irradiation is more efficacious than decellularization. Namely, a membrane for preventing adhesion, by which adhesion can be prevented without inducing troublesome reactions (for example, calcification, an inflammatory reaction, unnecessary cell migration or adhesion, platelet aggregation, acceleration of blood coagulation, etc.), is provided.
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease of undetermined etiology. Cardiac involvement is common in SLE and constitutes one of the main causes of mortality. More recently, new ultrasound imaging techniques, such as transthoracic ultrasound (TTE) with strain evaluation, have appeared and seem promising for the detection of cardiac involvement. The objective of our work was to study the frequency and characteristics of ultrasound abnormalities found in lupus patients and to study the benefit of ultrasound with global longitudinal strain (GLS) for early management.
METHODS: It was an observational study of patients followed for SLE at the internal medicine and cardiology department of the HMPIT for 6 months (May-November 2023). The definition of cardiac involvement was by ultrasound. All patients benefited from TTE coupled with 2D-strain. We divided the workforce into two groups: the first group (patients with heart disease) and the second group (patients without heart disease).
RESULTS: In a series of 40 lupus patients including 33 women and seven men, cardiac manifestations were reported in 60% of patients. In the first group, 29% had palpitations, 25% had chest pain, 67% had dyspnea, 37% had pericarditis, 8% had pulmonary arterial hypertension (PAH) and 12% had myocarditis. The comparative study showed that patients in the first group presented significantly more frequently with dyspnea (p = 0.02), chest pain (p = 0.03) and serositis (p = 0.01) compared to those in the second group. The mean left ventricular ejection fraction (LVEF) did not show a significant difference between the two groups. On the other hand, the average Global Longitudinal Strain (GLS) was significantly altered in the first group (p = 0.01). Furthermore, the frequency of pathological GLS was significantly higher in patients with lupus heart disease (p < 0.01).
CONCLUSION: Cardiac involvement during SLE is a frequent and most often asymptomatic complication. A systematic search for this impairment using a high-performance echocardiography examination, namely the 2D GLS, is essential for early treatment.