anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Hereditary spastic paraplegias (HSPs) comprise a family of degenerative diseases mostly hitting descending axons of corticospinal neurons. Depending on the gene and mutation involved, the disease could present as a pure form with limb spasticity, or a complex form associated with cerebellar and/or cortical signs such as ataxia, dysarthria, epilepsy, and intellectual disability. The progressive nature of HSPs invariably leads patients to require walking canes or wheelchairs over time. Despite several attempts to ameliorate the life quality of patients that have been tested, current therapeutical approaches are just symptomatic, as no cure is available. Progress in research in the last two decades has identified a vast number of genes involved in HSP etiology, using cellular and animal models generated on purpose. Although unanimously considered invaluable tools for basic research, those systems are rarely predictive for the establishment of a therapeutic approach. The advent of induced pluripotent stem (iPS) cells allowed instead the direct study of morphological and molecular properties of the patient's affected neurons generated upon in vitro differentiation. In this review, we revisited all the present literature recently published regarding the use of iPS cells to differentiate HSP patient-specific neurons. Most studies have defined patient-derived neurons as a reliable model to faithfully mimic HSP in vitro, discovering original findings through immunological and -omics approaches, and providing a platform to screen novel or repurposed drugs. Thereby, one of the biggest hopes of current HSP research regards the use of patient-derived iPS cells to expand basic knowledge on the disease, while simultaneously establishing new therapeutic treatments for both generalized and personalized approaches in daily medical practice.
Adenosine triphosphate metallic complexes are new. Pref complexes are those with metals of the iron group, platinum group, alkaline-earth metals, groups Ib, VIIa and IIb of the periodic table and with octinides. Manganese, cobalt, nickel, copper, zinc, uranyl (UO22+), chromium, iron, thorium, calcium and strontium complexes are specifically claimed. The complexes influence metabolic processes and may be used to treat cerebro-vascular and cerebro-sclerotic troubles, to aid the healing of bone tissue after fractures etc., to treat osteoporosis, osseous cysts etc., and to stimulate, inhibit or completely eliminate the function of various cells. Typically the ATP-Co complex administered intravenously or intramuscularly at 5-10mg. per day has been used to treat iochemic lesions and anoxia. Its activity is compared with scanthanol nicotinate (complamin) and Xavine; the ATP-complexes having the advantage that they are also vasodilators. The complexes may be administered orally or parenterally. Activity tests are described.
Participants will receive escalating doses of GSK3326595 until the maximum tolerated dose level is reached. The recommended phase 2 dose (RP2D) will be determined. Participants will be dosed in a fed (high-fat, high-calorie meal) and fasted state to determine the effect of food on bioavailability of GSK3326595, and will be dosed with tablet and capsule to compare two formulations of GSK3326595 (capsule versus tablet).
Patients receive standard educational materials about breast cancer risk and chemoprevention in RealRisks via the patient portal or website. Patients receive patient-centered decision support within the patient portal via an action plan summarizing their breast cancer risk profile, their risks and benefits of SERMs and AIs, and personal preferences for chemoprevention. Health care providers receive decision support and action plans based on their patients' interactions with RealRisks via the BNAV provider-centered support tool within the EHR. A sample of patients participate in an audio-recorded interview via telephone or video conference over 45-60 minutes at 12 months after registration. A sample of health care providers participate in 3 audio-recorded interviews via telephone or video conference over 45-60 minutes each at baseline, within 12-36 months after study activation, and within 12 months after study closure to accrual.
Disclosed are peer-to-peer mobile applications that manage secure and intelligent communication between medical providers, patients, and/or physicians. The mobile application can be configured to provide an encrypted mixed media messaging system between registered users that provide, for example, a HIPAA compliant messaging platform. A secure messaging system can controls delivery of the mobile application and provide functionality to enable providers to control the messaging environment. The secure messaging system can be architected to provide geographically located servers. The geographically located servers can be configured to manage secure communication and implement geographically based communication requirements. In various embodiments, a plurality of communication management servers can be located in multiple jurisdictions, each managing respective communication requirements and/or restrictions.
Systems and techniques for comparing orthodontic setups are disclosed. The method involves receiving an instant orthodontic setup and a reference orthodontic setup, both comprising three-dimensional (3D) representations of one or more teeth. The processing circuitry compares at least one aspect of the instant orthodontic setup with the corresponding aspect of the reference orthodontic setup to compute a comparison metric. The comparison metric represents the degree of similarity or dissimilarity between the two setups. The processing circuitry then outputs the computed comparison metric. These systems and techniques enable efficient and accurate comparison of orthodontic setups, aiding in the evaluation and assessment of treatment plans and facilitating informed decision-making in orthodontic procedures.
Cellulose from bacteria is a high-purity biomaterial naturally produced by bacteria as part of their metabolic process. Although it inherently lacks antimicrobial activity, its modification with bioactive substances can significantly enhance its efficacy beyond that of the original compounds. This biomaterial features a unique ability to retain substantial quantities of liquids within its three-dimensional network, making it a prime candidate for biomedical applications. Versatile in its properties, it can be utilized across various industries. Previous research has highlighted its capacity to exhibit antimicrobial properties and to encapsulate nanostructured materials, thereby augmenting its antibacterial effectiveness. This review focuses on the use of cellulose from bacteria as a carrier for active compounds, specifically targeting antibacterial activity against drug-resistant strains. We explore its role in innovative bacterial cellulose-based systems, which present a promising solution for tackling bacterial resistance. This review aims to showcase the potential of bacterial cellulose in developing new devices and treatment strategies that address critical concerns in global health.
An accurate diagnosis of lower limb deep vein thrombosis (DVT) recurrence is mandatory. The diagnosis is difficult and has not been well investigated. Our objective was to define the role of clinical probability assessment, D-dimer assay, venous ultrasound and other imaging methods in the diagnosis of this condition based on a review of published data. Our review did not find any clinical prediction rule (CPR) specific to the diagnosis of DVT recurrence. D-dimer assays have not been sufficiently validated or proved effective either alone or when combined with the assessment of clinical probability or with ultrasound. The only validated ultrasound criteria are a new non-compressible vein segment and a≥2mm or>4mm increase in diameter of the common femoral or popliteal vein under compression in the transverse plane between two examinations. Limitations of these criteria include poor inter-observer agreement, non-availability of previous ultrasound reports and measurements, a high percentage of non-diagnostic ultrasound results, lack of power in diagnostic accuracy and diagnostic management studies, and lack of external validation. The analysis of venous obstruction, thrombus appearance, vein diameter and blood flow based on colour Doppler ultrasound criteria has not yet been validated in studies. Magnetic resonance direct thrombus imaging (MRDTI) is a new promising diagnostic imaging method, but is hardly accessible, costly and needs large scale validation studies. Based on this review, an update of the guidance for clinical practice is proposed for the diagnostic management of patients with clinically suspected lower limb DVT recurrence.
The invention discloses a traditional Chinese medicine preparation for treating psoriasis. The traditional Chinese medicine preparation is prepared from, by weight, 25-35 parts of radix angelica sinensis, 25-35 parts of radix rehmanniae preparata, 25-35 parts of cortex pseudolaricis, 15-25 parts of cortex albiziae, 15-25 parts of ramulus cinnamomi, 15-25 parts of herb of cavalerie mosla, 15-25 parts of squama manis, 5-15 parts of herb of humulus scandens (Lour.) Merr. and 5-15 parts of dried feces of bombyx mori Linnaeus.. A preparation method comprises the steps that all the raw materials are taken, mixed and ground into fine powder, 200-mesh sieving is conducted, medical vaseline is added and prepared into paste, and the traditional Chinese medicine preparation is obtained. The traditional Chinese medicine preparation mainly treats the psoriasis, in the treating process, the medicine is externally applied, an appropriate amount of medicine is taken to be smeared on the affected part once or twice a day, and one course of treatment is one month; the medicine takes effect within one month, and the psoriasis can be cured within one month to five months. According to the traditional Chinese medicine preparation for treating the psoriasis, by applying the traditional Chinese medicine preparation for many years, the effects of achieving desquamation and relieving itching are good, the treatment effect is good, the psoriasis is not prone to relapse after being cured, and no toxic or side effect exists.
1. Technical Result Increase in treatment efficiency of diseases caused by cyclooxygenase-2.                 2. Essence Crystal forms of celecoxib I and II have the mentioned values of difractogram of powder, thermograms of differential scanning calorimetry and other physical properties in the description. The mentioned crystal forms of celecoxib are suitable for treatment and prevention of diseases caused by cyclooxygenase-2, methods for their production and pharmaceutical compositions containing the same.         3. Field of Application Medicine.
Distal sensory peripheral neuropathy (DSP) is a chronic, debilitating painful condition affecting quality of life in persons with Type 2 diabetes mellitus (T2DM). According to the Centers for Disease Control (CDC), 29 million Americans are living with T2DM. Treatments prescribed to manage DSP pain, such as nonnarcotic and narcotic analgesics, antidepressants and anticonvulsants, are largely ineffective. Effective management of DSP pain is an unmet therapeutic need for this population.

This is a randomized, blinded, placebo-controlled clinical trial to determine feasibility and preliminary efficacy of Moxibustion (Moxa) for persons with T2DM DSP lower limb pain/discomfort. Participants with lower limb DSP pain/discomfort are randomized to one of four Conditions: 1) Traditional Moxa, 2) Smokeless Moxa 3) Placebo Moxa (control), or 4) WaitList (control). Participation involves a preliminary phone screening, provider verification of medical condition, intake baseline session, neurologicial evaluations, treatment sessions and follow ups. Participants assigned to the moxibustion conditions will be blind to treatment assignment, attend a screening session, followed by twice-weekly treatment sessions for 3 weeks, complete the same instruments and submit prospective symptom diaries (SD). Subjects randomized to the WaitList control condition experience all aspects of study participation with the exception of receiving moxibustion (during the study). They undergo all screening and eligibility assessments; attend study visits; submit and review their symptom diaries, update concomitant medication, complete assessment instruments; receive neuro/NST assessments and compensation. In all respects, participants in the Control groups receive the same concern as subjects assigned to the other groups. All moxibustion interventions will be implemented by licensed acupuncturists.
The invention relates to the technical field of medical image processing, in particular to an automatic diagnosis and identification system and method based on an AI image focus, aiming at improving the efficiency and the universality of medical image diagnosis. The system comprises a data collection module, a data preprocessing module, a feature extraction module, a model training module, a prediction and evaluation module, a system integration module, a notification and alarm module and an automatic operation and maintenance module. The data collection module is responsible for collecting various medical image data, including CT, MRI, X-rays, which may be derived from an online database, medical institution or research institution. The data preprocessing module performs preprocessing operations such as format conversion, image enhancement, denoising and segmentation on the original medical image so as to improve the image quality and definition. The invention improves the efficiency and the universality of medical image diagnosis. By adopting the model with higher universality, doctors do not need to maintain an independent model for each disease, so that the diagnosis flow of multiple diseases is accelerated, and redundant work is reduced.
Heterogeneous nuclear ribonucleoproteins (hnRNPs), a group of proteins that control gene expression, have been implicated in many post-transcriptional processes. SYNCRIP (also known as hnRNP Q), a subtype of hnRNPs, has been reported to be involved in mRNA splicing and translation. In addition, the deregulation of SYNCRIP was found in colorectal cancer (CRC). However, the role of SYNCRIP in regulating CRC growth remains largely unknown. Here, we found that SYNCRIP was highly expressed in colorectal cancer by analyzing TCGA and GEPIA database. Furthermore, we confirmed the expression of SYNCRIP expression in CRC tumor and CRC cell lines. Functionally, SYNCRIP depletion using shRNA in CRC cell lines (SW480 and HCT 116) resulted in increased caspase3/7 activity and decreased cell proliferation, as well as migration. Meanwhile, overexpression of SYNCRIP showed opposite results. Mechanistically, SYNCRIP regulated the expression of DNA methyltransferases (DNMT) 3A, but not DNMT1 or DNMT3B, which affected the expression of tumor suppressor, p16. More importantly, our in vivo experiments showed that SYNCRIP depletion significantly inhibited colorectal tumor growth. Taken all together, our results suggest SYNCRIP as a potent therapeutic target in colorectal cancer.
The gut microbiota is an important factor responsible for the physiological processes as well as pathogenesis of host. The communication between central nervous system (CNS) and microbiota occurs by different pathways i.e., chemical, neural, immune, and endocrine. Alteration in gut microbiota i.e., gut dysbiosis causes alteration in the bidirectional communication between CNS and gut microbiota and linked to the pathogenesis of neurological and neurodevelopmental disorder. Therefore, now-a-days microbiota-gut-brain-axis (MGBA) has emerged as therapeutic target for the treatment of metabolic disorder. But, experimental data available on MGBA from basic research has limited application in clinical study. In present study we first summarized molecular mechanism of microbiota interaction with brain physiology and pathogenesis via collecting data from different sources i.e., PubMed, Scopus, Web of Science. Furthermore, evidence shows that adipose tissue (AT) is active during metabolic activities and may also interact with MGBA. Hence, in present study we have focused on the relationship among MGBA, brown adipose tissue, and white adipose tissue. Along with this, we have also studied functional specificity of AT, and understanding heterogeneity among MGBA and different types of AT. Therefore, molecular interaction among them may provide therapeutic target for the treatment of neurological disorder.
<P>PROBLEM TO BE SOLVED: To provide a membrane-penetrating receptor, more particularly, an endogenous human orphan G protein coupled receptor.  <P>SOLUTION: This invention provides a G protein coupled receptor ([GPCR]) encoded by a cDNA comprising a specified base sequence, a plasmid comprising a cDNA comprising a specified base sequence, and a host cell comprising the plasmid. As regards the identification of the human GPCRs, some of the disclosed endogenous human GPCRs are identified according to the reinvestigation of the GenBank database information. The other disclosed endogenous human GPCRs are identified by carrying out the BLAST search of the EST database (dbsest) using specified EST clones as query sequences. Thereafter, a human genome library is screened by using the identified specified EST clones as probes.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Geriatric patients scheduled to undergo surgery were tested with Mini Mental State Examination (MMSE) in the preoperative visit. MMSE was repeated postoperatively at the 6th hour, the 1st, 3rd, and 7th day. Visual analogue scale (VAS) test was performed simultaneously on the postoperative 6th hour, the 1st, 3rd, and 7th day. Two cohorts were created according to the amount of fresh gas flow (low flow vs high flow) in the maintenance phase of the inhalational anesthetic. MMSE scores were compared between cohorts and baseline. VAS scores were compared between cohorts.
This group will continue with their current treatment regimen during the course of the study. In addition they will be given an active intervention with the Flowaid FA-100 SCCD device to utilize at home daily. They will be monitored with daily questionnaires, and at the end of trial visit will also undergo a QST evaluation.
PROBLEM TO BE SOLVED: To provide a mold material for a dental high temp. active metal which lowers firing temp. of the mold, compensates casting shrinkage of a casting material and improves the adaptability precision, and a casting method of the high temp. active metal for dentistry. SOLUTION: In the mold material for casting containing aggregate blending auxiliary aggregate into main aggregate composed of alumina and magnesia, binder and additive, the additive is composed of at least one kind selected among group of lithium fluoride, aluminum fluoride, barium fluoride, sodium chloride, calcium chloride, lithium chloride, lithium bromide, boron oxide and calcium borate, and the firing temp. of the molding material is lowered to <=900$0C. The binder is composed of at least one kind selected among group of ammonium phosphate, aluminum phosphate, aluminum cement, zirconia sol, basic lactate compound, ethyl silicate and colloidal silicate.
Recent studies show that a certain group of drugs (dideoxynucleosides) are effective in treating patients with HIV infection. ddC is a dideoxynucleoside and test tube studies show that it may be valuable in treating AIDS patients. ddC has been shown to be well tolerated in certain patients with AIDS.

A range of doses of ddC is given to patients with AIDS and ARC. Eight patients with AIDS and eight patients with ARC are given ddC at the lowest level for 12 weeks. Patients who respond with a rise in their number of T4 cells or with a fall in HIV antigen in their serum (the fluid portion of the blood) are continued at that dose for an additional 12 weeks. Patients who do not respond at a given dose level (no rise in T4 or fall in serum HIV antigen) stop treatment at 12 weeks. All patients are followed off therapy for 4 weeks. As each dose level is found to be well tolerated for 10 weeks in five of the eight patients in each group, additional patients will be entered at higher dose levels until eight AIDS and eight ARC patients are receiving the drug at a given level.
BACKGROUND: Nutritional imbalance is an underlying cause of 2.6million death annually and a third of child's death globally. This study assessed and compared the nutritional status of primary school children and their caregiver's knowledge on malnutrition in rural and urban communities of Ekiti State.
METHODS: This is a cross-sectional comparative study carried out among 983 urban and rural primary school children in Ekiti State (495 in urban and 488 in rural) using interviewer-administered semi-structured questionnaire. A multi-stage sampling technique was used and data collected was analyzed using SPSS 23 with level of statistical significance set at p < 0.05.
RESULTS: Underweight and stunting were relatively higher in rural (6.5% and 22.7% respectively) than in urban (6.3% and 19.4% respectively) and these differences are not statistically significant (p = 0.898, p = 0.197). However, wasting, overweight and obesity were higher in urban (12.7%, 6.1% and 7.7% respectively) than rural (11.5%, 3.7% and 7.5% respectively) but the difference is not statistically significant. (p = 0.242). Majority of the caregivers in both settings had good knowledge of malnutrition though higher in urban mothers (89.5%) with statistical significance than their rural counterparts (71.5%). However, there is no significant association between caregiver's knowledge and malnutrition in this study. Being in lower primary school class, relationship with caregiver, educational status of caregiver and occupation of caregiver were the common predictors of malnutrition among the school children in both community settings.
CONCLUSION: Generally, the prevalence of malnutrition was high in both urban and rural primary school children in this study. However, while underweight and stunting were more prevalent among the children in the rural communities, wasting, overweight and obesity were more prevalent in the urban. The caregivers in both communities had good knowledge of malnutrition (better in the urban) but this is not good enough to bring a significant relationship with the occurrence of malnutrition in the children. Common predictors of malnutrition in both community settings are being in lower primary school class, relationship with caregiver, educational status of caregiver and occupation of caregiver. It is therefore recommended that regular continuous public enlightenment, nutritional education programmes and other programmes targeted at improving the economic power of the caregivers are measures that will improve the nutritional status of the primary school children.