anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces functional and/or structural changes in the placental-fetal unit remain poorly understood. Maternal circulating small extracellular vesicles (sEVs) are good candidates to act as "stress signals" in mother-to-fetus communication. Using a repetitive restraint-based rat model of prenatal stress, we examined circulating maternal sEVs under stress conditions and tested whether they could target placental-fetal tissues.
RESULTS: Our mild chronic maternal stress during pregnancy paradigm induced anhedonic-like behavior in pregnant dams and led to intrauterine growth restriction (IUGR), particularly in male fetuses and placentas. The concentration and cargo of maternal circulating sEVs changed under stress conditions. Specifically, there was a significant reduction in neuron-enriched proteins and a significant increase in astrocyte-enriched proteins in blood-borne sEVs from stressed dams. To study the effect of repetitive restraint stress on the biodistribution of maternal circulating sEVs in the fetoplacental unit, sEVs from pregnant dams exposed to stress or control protocol were labeled with DiR fluorescent die and injected into pregnant females previously exposed to control or stress protocol. Remarkably, maternal circulating sEVs target placental/fetal tissues and, under stress conditions, fetal tissues are more receptive to sEVs.
CONCLUSION: Our results suggest that maternal circulating sEVs can act as novel mediators/modulators of mother-to-fetus stress communication. Further studies are needed to identify placental/fetal cellular targets of maternal sEVs and characterize their contribution to stress-induced sex-specific placental and fetal changes.
BACKGROUND: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization. This study aimed to determine the role of netrin-1 from the metastatic bone microenvironment in BCP development and identify the associated signaling pathway for the strategy of BCP management.
METHODS: The rat BCP model was established by intratibial implantation of Walker 256 cells. Von Frey filaments measured the mechanical pain threshold. Movement-induced pain was assessed using limb use scores. Expressions of associated molecules in the affected tibias or dorsal root ganglia (DRG) were measured by immunofluorescence, immunohistochemistry, real-time quantitative polymerase chain reaction, or western blotting. Transduction of deleted in colorectal cancer (DCC) signaling was inhibited by intrathecal injection of DCC-siRNA.
RESULTS: In BCP rats, the presence of calcitonin gene-related peptide (CGRP)-positive nerve fibers increased in the metastatic bone lesions. The metastatic site showed enrichment of well-differentiated osteoclasts and expressions of netrin-1 and its attractive receptor DCC. Upregulation of DCC and increased phosphorylation levels of focal adhesion kinase (FAK) and Rac family small GTPase 1/Cell division cycle 42 (Rac1/Cdc42) were found in the DRG. Intrathecal administration of DCC-siRNA led to a significant reduction in FAK and Rac1/Cdc42 phosphorylation levels in the DRG, decreased nociceptive nerve innervation, and improved pain behaviors.
CONCLUSIONS: Netrin-1 may contribute to the activation of the BCP by inducing nociceptive nerve innervation and improving pain behaviors.
FIELD: medicine, nephrology. SUBSTANCE: invention proposes a novel agent for correction of components of blood complement system used in treatment of chronic pyelonephritis. Agent represents the known immunomodulating agent im(m)unofan (hexapeptide of structure: Arg-α-Asp-Lys-Val-Tyr-Arg). Invention indicates on the specific of effect of the proposed compound. EFFECT: expanded assortment of agent used in treatment of chronic pyelonephritis, valuable medicinal properties of agent. 3 tbl
The cerebral palsy children will play the engineer-built system, video-game based Kinect sensor 3 times/week for 5 weeks. Each session will last for 40 minutes. The video-game Kinect sensor was developed by the researcher team.
The early stages of brain injury can induce acute liver injury, which can be recovered in the short term. Continued medication treatment during hospitalization for brain injury alleviates the prognosis and contributes to a high incidence of drug-induced liver injury (DILI). We hypothesize that there is an interaction between changes in the hepatic environment after brain injury and liver injury produced by intensive drug administration, leading to an upregulation of the organism's sensitivity to DILI. In this study, mice models of TBI were established by controlled cortical impact (CCI) and models of DILI were constructed by acetaminophen (APAP). All mice were divided into four groups: Sham, TBI, APAP, and TBI+APAP, and related liver injury indicators in liver and serum were detected by Western blot, Quantitative real-time PCR (qRT-PCR), and immunohistochemical staining. The results suggested that liver injury induced in the early stages of brain injury recovered in 3 days, but this state could still significantly aggravate DILI, represented by higher liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]), oxidative stress (increase in malondialdehyde [MDA] concentration and deregulation of glutathione [GSH] and superoxide dismutase [SOD] activities), inflammatory response (activation of the HMGB1/TLR4/NF-κB signaling pathway, and increased messenger RNA [mRNA] and protein levels of pro-inflammatory cytokines including tumor necrosis factor alpha [TNF-α], interleukin [IL]-6, and IL-1β), and apoptosis (TUNEL assay, upregulation of Bax protein and deregulation of Bcl-2 protein). In summary, our results suggested that TBI is a potential susceptibility factor for DILI and exacerbates DILI.
A mobile medicine storage unit for individuals under a doctor's care. The unit is programmable and preferably fully automatic, but also manual, in dispensing any number of medications up to four times per day at preselected times. Audible and visible indicators alert patients of proper dosages and timings of these doses. An optional integral water reservoir and cup dispenser makes it possible to properly take all medications with minimal effort at the unit. Patients not in close proximity to the unit will be alerted remotely via a pager. The unit will contact programmable emergency phone numbers when no patient response is received. Programmability allows customizing to accommodate individual medication needs. Mobility is aided by an optional wheeled cart.
In some embodiments, the invention provides methods and compositions for inducing de novo tertiary lymphoid structure in a subject. In some embodiments, such methods comprise administering an IL33 protein to a subject. In some embodiments, the subject has cancer. In some embodiments, the subject has a chronic inflammatory condition. In some embodiments, the invention provides methods for treating cancer. In some embodiments, the invention provides methods for treating chronic inflammatory conditions.
This is a multi-center, randomized, controlled trial to assess the real-world effectiveness of a mobile-delivered, prescription digital therapeutic (PDT) device delivering Cognitive Behavioral Therapy for Insomnia (i.e., Somryst, herein called PEAR-003b) using a novel patient-centered data sharing platform (called Hugo), with linkage to Fitbit (Inspire 2), among 100 patients with chronic insomnia. Half of the patients with insomnia will receive the PEAR-003b digital therapeutic with linkage to the Hugo platform and Fitbit (Inspire 2) and half of the patients with insomnia will not receive the PDT but will receive a Fitbit and be enrolled in the Hugo platform. The treatment duration will be 9 weeks with a 21-, 35-, and 61-week follow-up. All patients will be evaluated at baseline, as well as prompted to complete additional assessments at weeks 9, 21, 35, and 61. The PEAR-003b intervention will deliver CBT-I via mobile devices as 6 treatment core modules over 9 weeks. Additionally, the Hugo platform will be used to collect patient-generated engagement data, healthcare utilization outcomes, and patient activity/clinical outcomes. These real-world data points and trends collected as part of this pilot investigation will help inform a future larger healthcare effectiveness and outcomes research study.
Air pollutants, such as particulate matter (PM) and diesel exhaust particles (DEP), are associated with respiratory diseases. Therefore, preventive and therapeutic strategies against PM-and DEP (PM10D)-induced respiratory diseases are needed. Herein, we evaluate the protective effects of a mixture of Lactiplantibacillus plantarum KC3 and Leonurus Japonicas Houtt (LJH) extract against airway inflammation associated with exposure to PM10D. To determine the anti-inflammatory effects of the LJH extract, reactive oxygen species (ROS) production and the expression of inflammatory pathways were determined in PM10-induced MH-S cells. For the respiratory protective effects, BALB/c mice were exposed to PM10D via intranasal injection, and a mixture of L. plantarum KC3 and LJH extract was administered orally for 12 days. LJH extract inhibited ROS production and the phosphorylation of downstream factors of NF-κB in PM10-stimulated MH-S cells. The mixture of L. plantarum KC3 and LJH repressed the infiltration of neutrophils, reduced the immune cells number, and suppressed the proinflammatory mediators and cyclooxygenase (COX)-2 expressions in PM10D-induced airway inflammation with reduced phosphorylation of downstream factors of NF-κB. In addition, these effects were not observed in an alveolar macrophage depleted PM10D-induced mouse model using clodronate liposomes. The extract mixture also regulated gut microbiota in feces and upregulated the mRNA expression of Foxp3, transforming growth factor (TGF)-β1, and interleukin (IL)-10 in the colon. The L. plantarum KC3 and LJH extract mixture may inhibit alveolar macrophage- and neutrophil-mediated inflammatory responses and regulate gut microbiota and immune response in PM10D-induced airway inflammation, suggesting it is a potential remedy to prevent and cure airway inflammation and respiratory disorders.
INTRODUCTION: The purposes of the present study were to (1) describe the prevalence of contralateral knee pain exacerbation after total knee arthroplasty (TKA), (2) explore the risk factors for pain exacerbation, and (3) verify the association of contralateral knee pain with future functional activity.
MATERIALS AND METHOD: We consecutively recruited outpatients with osteoarthritis of both knees who had primary TKA planned. The contralateral knee pain using a Numerical Rating Scale (NRS) and the functional activities subdomain of the new Knee Society Knee Scoring System (KSS) were assessed preoperatively and at 1, 3, and 6 months postoperatively. Among patients with < 5 NRS points preoperatively, we described the frequency of the contralateral knee pain exacerbation, defined as a ≥ 2-point increase from preoperative pain at each postoperative visit. An exploratory analysis was performed to identify preoperative risk factors for contralateral knee pain exacerbation. A linear mixed model was fit to examine the association of the contralateral knee pain with KSS functional activities at subsequent visits.
RESULTS: Among 315 patients, 14.6%, 24.1%, and 27.6% of patients experienced contralateral knee pain exacerbation at 1, 3, and 6 months postoperatively, respectively. The identified preoperative risk factors were low quadriceps strength and higher Kellgren-Lawrence grade on the non-operative knee, along with severe pain on the operative knee. The magnitude of the association between contralateral knee pain and worsening KSS functional activities increased with subsequent visits (p for interaction < 0.001).
CONCLUSION: The frequency and impact of pain exacerbation on the contralateral knee increase after TKA and should be carefully evaluated for a prolonged period of time.
PURPOSE: A composition using tomato plant extract and Lithospermum erythrorhizon extract is provided to detoxify smoking toxicity. CONSTITUTION: A composition for detoxifying smoking toxicity contains Lithospermum erythrorhizon extract as an active ingredient. The Lithospermum erythrorhizon extract is prepared by dipping leaves, stems, roots, or mixture of Lithospermum erythrorhizon in 50% ethanol, isolating at 50°C for 10 hours, and decompression-concentrating. The composition is a food or pharmaceutical composition. The food composition is gum, beverage, and jelly. The pharmaceutical composition is oral formulation, parenteral formulation, and topical formulation.
Immediately afterwards, a 1-mm thick layer of MAL (16% Metvix® cream, PhotoCure ASA, Oslo, Norway) was applied to the lesion and to 5 mm of surrounding healthy tissue. The area was covered with an occlusive dressing (Tegaderm, 3M, Saint Paul, MN, US) for 3 hours, after which the remaining cream was removed with saline gauze, and the red fluorescence of porphyrins was visualized with Wood's light. Each treatment area was then separately illuminated with red light-emitting diode (LED) lamps (Aktilite CL128; Galderma, Bruchsal, Germany) with peak emission at 632 nm and total light dose of 37 J cm2. Areas which were scheduled to receive MAL-PDT received the second treatment 7 days later.
PURPOSE: To prepare the subject formulation, containing a specific buffer ion and capable of preventing activities from beinglost during the storage in a liquid state, at the time of freeze-drying or during the storage in a freeze-dried state. CONSTITUTION: This stable blood plasma protein formulation comprises a blood plasma protein (e.g. factor VIII), 0.5-15mM sodium chloride or/and potassium chloride, 0.01-10mM lysine hydrochloride and 0.2-5.0mM histidine at pH6.0-7.6 of the aqueous solution. A saccharide selected from mannitol, sugar and maltose in an amount of <=10%wt./vol. can be added to the formulation for freeze-drying. In order to stabilize about 2-2,000mL freeze-dried aqueous solution of the blood plasma protein, about 0.058-1,754 mg Nacl, about 0.074-2,237mg KCI or a mixture thereof, about 0.0036-3,653mg lysine hydrochloride and about 0.062-1,552mg histidine are added thereto.
The invention belongs to the medicine field and particularly relates to aporosa dioica puffed granules and a preparation method thereof. The technology problem solved by the invention is to provide ball-like aporosa dioica puffed granules with smooth and compact apperances and good fluidity. The extraction or decocting technology can be performed according to the present method during the granulating process. The main difference between the method in the invention and the present method is making the granules into a state of compression. In the process of drying the granules, the moisture in the  granules  is controlled at 4-5 percent, then the granules are heated at high temperature to become puffed and the finished products of the granules are obtained by drying the puffed granules. The preparation method of the invention can form ball-shaped or ball-like granules with smooth surfaces and compact texture. The interiors of the particles have a phenomenon of cavitation expansion which enables the granules to have good shape and non-easily-broken property. An angle of repose of granules is between 10 DEG to 25 DEG. The granules prepared by the method have characteristics that the granules have good fluidity, do not easily absorb moisture and require less auxiliary material. Besides, the paste material is hard to appear when the granules are mixed with water, so that the mixing is very easy. The aporosa dioica granules of the invention can be used as a raw material for preparing tablets and capsules according to the ordinary technologies of compressing tablets and stuffing capsules.
Phase change material microcapsules are obtained using a PMMA prepolymer and an organic-solvent free synthesis process. A polymer monomer and an initiator are subject to pre-polymerization in a water bath to form Polymethyl methacrylate (PMMA) prepolymer which is then prepared to be a stabilizer aqueous solution. A phase change material is added to the stabilizer aqueous solution and liquefied in advance, and stirred to form an emulsion by a homogenizing mixer. A starting agent, a cross-linking agent and a Polymethyl methacrylate methyl ester prepolymer are added to the emulsion containing the phase-change material. The emulsion is further stirred by the homogenizing mixer for micro-emulsification which then aggregates in water bath. In this way, the process may use organic-solvent free process to pre-polymerize the polymer monomer into a Polymethyl methacrylate prepolymer and carries out encapsulation and polymerization at an oil-water interface to achieve the preparation of phase change material microcapsules.
The current noninvasive diagnostic approaches for detecting bladder cancer (BC) often exhibit limited clinical performance, especially for the initial diagnosis. This study aims to evaluate the validity of a streamlined urine-based PENK methylation test called EarlyTect BCD in detecting BC in patients with hematuria scheduled for cystoscopy in Korean and American populations. The test seamlessly integrates two steps, linear target enrichment and quantitative methylation-specific PCR within a single closed tube. The detection limitation of the test was approximately two genome copies of methylated PENK per milliliter of urine. In the retrospective training set (n = 105), an optimal cutoff value was determined to distinguish BC from non-BC, resulting in a sensitivity of 87.3% and a specificity of 95.2%. In the prospective validation set (n = 210, 122 Korean and 88 American patients), the overall sensitivity for detecting all stages of BC was 81.0%, with a specificity of 91.5% and an area under the curve value of 0.889. There was no significant difference between the two groups. The test achieved a sensitivity of 100% in detecting high-grade Ta and higher stages of BC. The negative predictive value of the test was 97.7%, and the positive predictive value was 51.5%. The findings of this study demonstrate that EarlyTect BCD is a highly effective noninvasive diagnostic tool for identifying BC among patients with hematuria.
An exemplary system, method, and computer-accessible medium for generating a Cartesian equivalent image(s) of a portion(s) of a patient(s), can include, for example, receiving non-Cartesian sample information based on a magnetic resonance imaging (MRI) procedure of the portion(s) of the patient(s), and automatically generating the Cartesian equivalent image(s) from the non-Cartesian sample information using a deep learning procedure(s). The non-Cartesian sample information can be Fourier domain information. The non-Cartesian sample information can be undersampled non-Cartesian sample information. The MRI procedure can include an ultra-short echo time (UTE) pulse sequence. The UTE pulse sequence can include a delay(s) and a spoiling gradient. The Cartesian equivalent image(s) can be generated by reconstructing the Cartesian equivalent image(s). The Cartesian equivalent image(s) can be reconstructed using a sampling density compensation with a tapering of over a particular percentage of a radius of a k-space, where the particular percentage can be about 50%.
Background: Trainees' experience in cleft surgery is limited due to the high-risk nature of the surgery and centralization of cleft care. Simulations allow trainees to learn complex surgical skills whilst ensuring patient safety. Existing cleft surgical simulators are over-simplified or prohibitively expensive. We developed and tested a high-fidelity yet cost-effective simulator for cleft palate repair.

Methods: Skeletal elements were obtained through high-resolution scanning of a pathologic specimen, 3D printed and then molded in plastic. Soft tissue components were formed through molding layers of silicone. 26 UK specialty trainees performed a vomerine mucosal flap and intra-velar veloplasty in a one-hour workshop. Pre- and post-simulation questionnaires assessing cleft knowledge and surgical confidence were compared for statistical significance.
PROBLEM TO BE SOLVED: To mensurate at any time in any place by making an information terminal having a specified number of electrodes switchable to an adipometric function, and using the electrodes for current supply and for voltage measurement, respectively, and calculating and displaying an adipose rate from the statue and weight and the measured voltage. SOLUTION: An information terminal having at least four electrodes, for example, a portable telephone T has a function selecting change-over switch 9, a display change-over switch 10, and a transfer switch 11, so that a both fat measurement can be performed by input of individual data such as sex, weight statue, age and the like. The electrodes are used at least by twos for current supply and voltage measurement, respectively. Namely, the forefingers and thumbs of the right hand and left hand are brought into contact with the electrodes A and B, C and D, respectively, constant current is supplied to the electrodes A, B, and the voltages generated in the electrodes C, D are measured. The adipose rate is calculated from the measured voltage values and the individual data such as statue and weight, and displayed on a display means 3.  According to this, a measurement can be performed at any time in any place.
A method for updating information about a subject of interest is disclosed. The method comprises assigning the subject a unique signal which signal is physically associated with the subject, identifying the unique signal, and displaying information related to the subject assigned to the unique signal soon after the signal is identified. The method is preferably used in a hospital setting. Also disclosed is a device, a system, and a control program for use in updating information. The device comprises a control logic responsive to an external stimulus, a wireless signal detection unit, and a display unit that displays information about a subject that has been identified. The control program is used with a wireless detector and comprises a feature that controls display, a feature that identifies a signal associated with a subject, and a feature that displays information in response to the identification feature. Security features can also be incorporated.
Telemedicine, the use of telecommunication and information technology to provide clinical health care from a distance, has become an increasing role in basic medical care internationally. Telemedicine is particularly suitable for skin diseases. In order to improve the use of evidence-based telemedicine, the Swiss patients' preferences regarding teledermatology versus face-to-face consultations and the patients' and physicians' determinants of acceptance for teledermatology are investigated in this study. Dermatology patients are asked to complete a newly-created 21-items-survey; Swiss dermatologists, other physicians and medical staff on telemedicine will complete a similar newly-created, 23-items-questionnaire. A descriptive statistical analysis (e.g. gender, age, place of residence (city or country), waiting time) will be performed.