anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention refers to a synthetic linear hybrid peptide, lacking disulfide bridges with antibiotic activity, and the variants thereof having up to 55% of identity, the peptides being designed and chemically synthesized from analogues such as Hadrurinae (Mexican Patent No. 985522, July 31, 2007) and Vejovina (Patent Application No. MX/a/2009 009090, August 26, 2009) isolated from Hadrurus gertschi and Vaejovis mexicanus scorpion venom respectively, with substantial modifications, which are not obvious for experts in the field, regarding the number of amino acids and the chemical nature thereof, in such a manner that it constitutes an new family of antibiotics (SEQID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, and SEQ ID NO: 10). This hybrid synthetic peptide and the antimicrobial variants thereof may inhibit the growth of bacteria culture. The originality of the new peptides is such that regardless of certain similarities to Hadrurinae, Vejovina, Opistoporina 1 and 2 and the Pandinina 1, these are unique since some analogues thereof (with less than 55% of identity of pair sequence in the 29 positions aligned to the SEQ ID NO: 2) are not functional. The invention also includes the pharmaceutical compositions for the application of the novel peptide and the DNA sequence encoding for the same.
The purpose of this study is to explore the potential application of photobiomodulation to irritable bowel syndrome. We established the following experimental groups: the Non-Stress + Sham group, which consisted of rats that were not restrained and were only subjected to sham irradiation; the Stress + Sham group, which underwent 1 hour of restraint stress followed by sham irradiation; and the Stress + Laser group, which was subjected to restraint stress and percutaneous laser irradiation bilaterally on the L6 dorsal root ganglia for 5 minutes each. The experiment was conducted twice, with three and two laser conditions examined. Following laser irradiation, a barostat catheter was inserted into the rat's colon. After a 30-minute acclimatization period, the catheter was inflated to a pressure of 60 mmHg, and the number of abdominal muscle contractions was measured over a 5-minute period. The results showed that photobiomodulation significantly suppressed the number of abdominal muscle contractions at average powers of 460, 70, and 18 mW. However, no significant suppression was observed at average powers of 1 W and 3.5 mW. This study suggests that photobiomodulation can alleviate visceral hyperalgesia induced by restraint stress, indicating its potential applicability to irritable bowel syndrome.
The present invention discloses a polypeptide with the fungus galactose agglutinin protein activity, a code sequence thereof, a preparation method thereof and an application thereof. The code sequence of the isolated protein has a sequence with at least 70% of autoploidy to a nucleotide sequence disclosed by SEQ ID NO. 1. The present invention relates to an isolated polypeptide which has a sequence with at least 80% of autoploidy to an amino acid sequence disclosed in SEQ ID NO. 2, the polypeptide coded by the nucleotide sequence, the preparation method of the polypeptide, and the application of the polynucleotide and the polypeptide in medicine and agriculture. The protein of the present invention has anti-tumor activity and anti-plant virus activity, and has great application value in the aspects of anti-tumor drug development, plant protection, etc.
The upper limb ischemic conditioning is composed of five cycles of bilateral upper limb ischemia intervened by reperfusion, which is induced by two cuff placed around the upper arms respectively and inflated to 200 mm Hg for 5 minutes followed by 5 minutes of reperfusion by cuff deflation. This therapy started within 2 hours after r-tPA thrombolytic therapy. In addition, all participants receive a standard clinical therapy.
PURPOSE: A pharmaceutical composition containing a compound and pharmaceutically acceptable carrier is provided to suppres Wnt/beta-catenin signal transduction system and to control Ras protein stability. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer contains pharmaceutically acceptable carrier and compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The cancer is caused by Ras mutation or Wnt signal transduction system disorder. The pharmaceutical composition is manufactured in a form of a tablet, capsule, pill, granule, powder, or liquid. The pharmaceutical composition is used for combination with an anticancer drug. A complex formulation contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof and the anticancer drug.
Continuous femoral nerve blockade infusion with Ropivacaine 0.2% + clonidine 150μg for postoperative pain management right after the end of the procedure.The PCA pump is programmed with continuous infusion (Ropivacaine 0.2% + clonidine 150μg) 2ml/h and bolus dosage 0,5ml per 15min (max dosage 2ml/h). The femoral catheter is placed preoperatively.
PROBLEM TO BE SOLVED: To improve the corresponding property in order to be safe to a human body and go along the shape of the body surface by a method wherein in a thin plate-form sheet made of a flexible resin, one or more magnetic effect elements are fixed, and on the face surface and the rear surface of the sheet above the magnetic effect elements, an opening which exposes the magnetic effect element at the same level as the resin film or by a slight difference in height, is formed. SOLUTION: One piece or a plurality of magnetic effect elements (magnets) 1 are fixed in a flexible resin sheet 2 in a manner to be enclosed. For the magnetic effect element 2, a conventional tablet-shape element can be used. For the flexible resin sheet 2, protuberances 5 are provided on the surface so that the magnets 1 may be enclosed, and on the resin film above the protuberance 5, a surface opening 3 is provided so that the surface of the magnet 1 may be exposed at the same level. On the rear surface, a rear surface opening 4 is provided in the same manner. By this constitution, the moving and the removal of a magnetizer are facilitated. Also, by the openings 3, 4, high and low magnetic forces can be obtained from the magnet attaching machine to be used.
Malignant tumors arising in the biliary tract and pancreas are aggressive malignancies characterized by a poor prognosis and most of cases are diagnosed at advanced stages and have poor outcome . The most common pancreatic cancer is ductal adenocarcinoma, which accounts for about 80% of all pancreatic cancers. Pancreatic cancer is a highly lethal gastrointestinal cancer with a low 5-year survival rate and difficulty in early detection . Biliary tract cancers can be divided into intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer. CEA and CA 19-9 are the most common used serum biomarker for cancer screening and the diagnosis of pancreatic and biliary cancer.

Platelets are an essential component of the tumor microenvironment and serve as local and systemic respondents during tumor initiation and tumor metastasis. After interaction with tumor cells or tumor associated biomolecules, platelets can alter their RNA profile, and this process give rise to the so-called tumor educated platelets (TEPs). Tumor cells can directly and indirectly produce changes on platelet RNA and protein content, emerging a new term called liquid biopsy which reflect the presence of cancer and thus give hope to many that they might precede protein markers as a cancer-specific biomarker. Alterations in the TEPs RNA profile have been described as a novel source of potential biomarkers and can be used for early detection of cancer and treatment monitoring. Platelet biomarker transcripts can be transferred from tumor cells to platelets, although in some studies, the putative origin of the biomarker is the megakaryocyte (endogenous).

Integrin Alpha 2b (ITGA2b) gene encodes a member of the integrin alfa chain family of proteins which is proteolytically processed to form subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor which is play crucial role in the blood coagulation system, by mediating platelets aggregation . Selectin P (SELP) gene encodes a protein that is stored in the alpha granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. ITGA2b and SELP are cancer related genes and of the mRNA TEPs putative endogenous biomarkers which have a high value for detection of cancer, so, tumor educated platelets (TEPs) broadened the spectrum of liquid biopsy applications, and may enable blood-based cancer diagnostics.
An exploratory-descriptive qualitative study will be conducted . This study will be conducted with 10 stroke patients receiving threshold electrical stimulation therapy. Threshold electrical stimulation will be applied for 4 weeks, 3 days a week, for one hour. At the end of the 4th week, semi-structured focus group interviews will be held with the patients. . In the semi-structured focus group interviews, the same questions will be asked to all participants and the verbal answers to these questions will be recorded with voice recorders. Compared to taking notes by hand; It will be preferable to record the conversation with a voice recorder because it has advantages such as recording all the interviews and allowing the interviewer to focus on the interview. Thematic analysis method will be used in the evaluation of the data.
In brain metastases, radiation necrosis (RN) is a complication that arises after single or multiple fractionated stereotactic radiosurgery (SRS/FSRS), which is challenging to distinguish from local recurrence (LR). Studies have shown increased RN incidence rates in non-small cell lung cancer (NSCLC) patients with oncogenic driver mutations (ODMs) or receiving tyrosine kinase inhibitors (TKIs). This study investigated enlarging brain lesions following SRS/FSRS, for which additional surgeries were performed to distinguish between RN and LR. We investigated seven NSCLC patients with ODMs undergoing SRS/FSRS for BM and undergoing surgery for suspicion of LR on MRI imaging. Descriptive statistics were performed. Among the seven patients, six were EGFR+, while one was ALK+. The median irradiation dose was 30 Gy (range, 20-35 Gy). The median time to develop RN after SRS/FSRS was 11.1 months (range: 6.3-31.2 months). Moreover, gradually enlarging lesions were found in all patients after 6 months post-SRS/FSR. Brain radiation necrosis was pathologically confirmed in all the patients. RN should be suspected in NSCLC patients when lesions keep enlarging after 6 months post-SRS/FSRS, especially for patients with ODMs and receiving TKIs. Further, this case series indicates that further dose reduction might be necessary to avoid RN for such patients.
A comprehensive package of digital health interventions to connect patients, patient champions and public health providers to improve the management of non-communicable diseases (NCDs) during the pandemic will be implemented, including 1) providing training to health providers regarding an integrated NCD-COVID guideline; 2) using a smartphone app to improve NCD case management and linking with patient champions; and 3) employing telementoring platform to improve quality of care. Patient champions are experienced patients who can provide peer support.
FIELD: medical equipment.SUBSTANCE: group of inventions relates to medical equipment, specifically to a method for controlling an infusion pump by means of a controller, designed to control the pump and obtain data from a glucose sensor and a diabetes management system. Method comprises obtaining a series of measurements of glucose concentration in a patient. Glucose measurements were taken by a glucose sensor to measure glucose for each time interval from a series of indexed discrete time intervals. Glucose calibration measurement is then taken during the time interval from a series of indexed time intervals to obtain a calibration index. Further, it is determined whether glucose measurement was performed outside the time interval from the series of indexed time intervals to obtain an omission index. Tuning factor is then determined based on both the calibration index and omission index. Amount of insulin administered is then calculated by a controller with control, based on a predictive model. Predictive model uses: the plurality of glucose measurements to predict a trend of the glucose level from estimates of a metabolic state of the patient and the tuning factor so as to provide a calculated insulin amount to be delivered to the patient for each interval of the indexed time interval. System for treating diabetes comprises a glucometer for the occasional measurement of glucose in the patient's blood at time intervals and presentation of a similar occasional blood glucose level in the form of calibration indices for each time interval in the indexed time interval. System also comprises a glucometer for continuous measurement of glucose level in the patient's blood through discrete uniform time intervals and representations of glucose level for each interval in the form of glucose measurement data, in which any omission of glucose measurement through any time interval is stored as an omission index. System comprises an infusion pump for insulin to deliver insulin and a controller, connected to the pump and glycometers. Controller determines the tuning factor based on the calibration index obtained during occasional glucose measurements, and the omission index for the control predictive model. Controller determines the speed of delivery of insulin for each time interval in the indexed time interval from the control predictive model based on the required glucose level.EFFECT: technical result is the adjustment of the control predictive model based on two variables obtained during continuous glucose monitoring.7 cl, 4 dwg, 5 tbl
BACKGROUND: A traditional Chinese medicine (TCM) formula, containing Astragalus membranaceus (Fisch.) Bunge, Aconitum wilsonii Stapf ex Veitch, Curcuma longa L., and Radix ophiopogonis (AACO), has therapeutic value for the treatment of chronic heart failure (CHF).
OBJECTIVE: This study intends to explore the pharmacological mechanism underlying the activity of the AACO formula against CHF.
MATERIALS AND METHODS: Using the TCM Systems Pharmacology database and Bioinformatics Analysis Tool for Molecular Mechanism of TCM, the active ingredients contained in the herbs of the AACO formula were screened. Meanwhile, the target genes related to these active ingredients were identified and genes correlated with CHF were screened. Protein-protein interaction networks were built to elucidate the relationships between the AACO formula and CHF. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathway enrichment analysis were carried out using the DAVID database. A "drug-component-target-disease" network was constructed with Cytoscape 3.7.0. The therapeutic effect of the AACO formula was proven by hemodynamic study, echocardiography evaluation, and histological analysis in transverse aortic constriction-induced CHF mice and was validated in vitro.
RESULTS: A total of 105 active ingredients and 1026 related targets were screened and identified, and 240 related targets overlapping with CHF were selected. According to GO analysis, the enriched genes participated in gene expression and cardiac contraction regulation by Ca2+ regulation. From KEGG analysis, the calcium axis was identified as one of the main mechanisms through which the AACO formula exerts an anti-CHF effect. AACO was validated to significantly improve cardiac diastolic and systolic functions in vivo via an increase in the rate of Ca2+ reuptake of the myocardial sarcoplasmic reticulum and improved myocardial contractility in vitro.
CONCLUSIONS: Network pharmacology is a convenient method to study the complex pharmacological mechanisms of TCM. The calcium axis likely participates in the anti-CHF mechanism of AACO.
A system for assessing risk of type 2 mellitus diabetes complication includes a data acquisition module and a risk assessment module. The data acquisition module obtains assessment parameters of a patient with type 2 mellitus diabetes and inputs the assessment parameters into the risk assessment module. The risk assessment module inputs the assessment parameters into a risk equation and uses the risk equation to calculate a risk value of complication that occurs after a period of time. The risk equation for all diabetic complications (i,j) is: ra(t,i,j)= 1 - exp{[H(t0) - H(t1)]Ca(t,i,j)} ra(t, i, j) is a risk value for the patient to occur the complication j from current disease i at age t. t0 is an age of the patient at i state. t1 is an age of the patient after the period of time. t is an age between t0 and t1. H(t0) and H(t1) are hazards of the complication occurring at the age t0 and the age t1, respectively. Ca(t, i, j) is Cox proportional hazards regression expression, and Ca(t, i, j) is as follows: Ca(t,i,j) = exp(Ra(t,i,j)) Ra(t, i, j) is a influence degree of the risk factors X on the complication j.
Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney cancer (ccRCC) in patients. To mimic stem cell responses in the normal kidney in vitro in a marker-unbiased fashion, we have established tubular organoids (tubuloids) from total single adult mouse kidney epithelial cells in Matrigel and serum-free conditions. Deep proteomic and phosphoproteomic analyses revealed that tubuloids resembled renewal of adult kidney tubular epithelia, since tubuloid cells displayed activity of Wnt and Notch signaling, long-term proliferation and expression of markers of proximal and distal nephron lineages. In our wish to model stem cell-derived human ccRCC, we have generated two types of genetic double kidney mutants in mice: Wnt-β-catenin-GOF together with Notch-GOF and Wnt-β-catenin-GOF together with a most common alteration in ccRCC, Vhl-LOF. An inducible Pax8-rtTA-LC1-Cre was used to drive recombination specifically in adult kidney epithelial cells. We confirmed mutagenesis of β-catenin, Notch and Vhl alleles on DNA, protein and mRNA target gene levels. Surprisingly, we observed symptoms of chronic kidney disease (CKD) in mutant mice, but no increased proliferation and tumorigenesis. Thus, the responses of kidney stem cells in the tubuloid and genetic systems produced different phenotypes, i.e. enhanced renewal versus CKD.
The present invention relates to a striped toothpaste system. The system comprises a multilayer plastic tube with barrier properties, a nozzle with an insert which contains striping orifices, and a toothpaste formulation contained in the tube. The toothpaste formulation consists of a minor portion with a particular colour forming the stripes, and a major portion having a different colour. The viscosity of the minor portion is 10,000-60,000 cP higher than the viscosity of the major portion. The toothpaste formulations contain between 0.05 and 0.6 % by weight of a carboxymethylcellulose binding agent. The system of the invention provides for the extrusion of properly striped ribbons of toothpaste upon repeated squeezing of the tube.
FIELD: medicine, phytotherapy. SUBSTANCE: larch wood of milled base of tree trunk that is the most enriched with diquertin is extracted with ethyl acetate. Extract is evaporated, treated with hot water and filtered off from impurities. From the cooled aqueous solution diquertin is crystallized that corresponds to indices of Temporary Pharmacopoeia Article. Proposed method is tested in experimental unit successively. Method involves the use only a single organic solvent that can be regenerated completely and provides high degree of extraction and required purity in industrial unit. EFFECT: improved method of preparing.
OBJECTIVES: Pharmacological postconditioning can protect against myocardial ischaemia-reperfusion injury during cardiac surgery with extracorporeal circulation. The aim of this study was to observe the protective effects of fructose-1,6-bisphosphate (FDP) postconditioning on myocardial ischaemia-reperfusion injury in patients undergoing cardiac valve replacement with extracorporeal circulation.
METHODS: Patients undergoing elective mitral valve replacement and/or aortic valve replacement were divided into normal saline postconditioning group (NS group) and FDP postconditioning group (FDP group). The primary outcome was the plasma concentration of creatine kinase-MB (CK-MB). The secondary outcomes were the plasma concentrations of lactate dehydrogenase, CK, high-sensitivity C-reactive protein, alpha-hydroxybutyrate dehydrogenase and cardiac troponin I, the spontaneous cardiac rhythm recovery profile, the extracorporeal circulation time and duration of surgery, intensive care unit and postoperative hospitalization.
RESULTS: Forty patients were randomly assigned to receive intervention and included in the analysis. The serum concentrations of CK-MB, lactate dehydrogenase, CK, cardiac troponin I, alpha-hydroxybutyrate dehydrogenase and high-sensitivity C-reactive protein at T1∼4 were lower in the FDP group than in the NS group (P < 0.001). Compared with the NS group, the dosage of dopamine administered 1-90 min after cardiac resuscitation, the spontaneous cardiac rhythm recovery time and the incidence of ventricular fibrillation were lower in the FDP group (P < 0.001, P < 0.001 and P = 0.040, respectively). The values of ST- changes were increased more significantly in the NS group than in the FDP group (median [standard deviation] 1.3 [0.3] mm vs 0.7 [0.2] mm; P < 0.001). Compared with the NS group, the time of recovery of ST-segment deviations was shorter in the FDP group (50.3 [12.3] min vs 34.6 [6.9] min; P < 0.001).
CONCLUSIONS: The FDP postconditioning could improve both myocardial ischaemia-reperfusion injury and the spontaneous cardiac rhythm recovery during cardiac valve surgery with extracorporeal circulation.