anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the present invention, the soup medicine, the tea, the health care drinks are decocted by 30g astragali, 15g Herbal Epimed, 30g Radix Paeoniae Alba, 10g raw licorice root, 10g dried plum and 10g kudzuvine root. The Chinese herb medicine can also be prepared as tablet, pill, injection, powder, oral liquid, aerosol, oils, sponge and gelatin capsule, in order to provide new function for diabetes. The present invention have the main function of treating the diabetes and functions of invigorating the kidney, benefiting vital energy, promoting the production of body fluid and retaining yin with astringent. The present invention is applicable for patients with diabetes of polydipsia, polyphagia, athrepsy, polyuria and sweet flavor. For patients with polydipsia, the gypsum, the RHIZOMA COPTIDIS from Sichuan of China, the caulis dendrobii, the anther dust, the fragrant solomonseal rhizome, the ophiopogonis tuber and the root of straight ladybell are added. For patients with frequent nocturia, the FRUCTUS PSORALEAE, the Chinese magnolia vine fruit, the cuscus seed, the Gordon Euryale and the corn cervi degelatinatum are added. For patients with drowsiness and debilitation, the Codonopsis pilosula, the polygonati, the angelica, the rehmannia dride rhizome, the atractylodes macrocephala, the batatatis, the Gold Theragran and the cola corii asini are added.
The present invention relates to blood group-free human blood plasma which is suitable for transfusion to patients with different blood groups in order to supply their blood and the preparation method thereof. It is a kind of plasma preparation. The present products are produced by incorporating protective agents with the blood plasma of blood groups A, B, O and AB, or blood groups A, B and AB, or blood groups A and B, O or AB. The present invention is not only convenient in using but also has a wide variety of raw material resources. It has a high rate of recovery of various coagulation factors. The present invention is totally provided with the clinical practicability, universal property, safety and effectiveness.
The warm-up exercise will be performed on an ergometric treadmill, through a protocol of 15 minutes of duration, with the first 5 minutes of acceleration, until reaching 30% of VO2max, the following 5 minutes of maintenance and the remaining 5 minutes being of slowdown. During the warm-up exercise, a pressure cuff will be used on each leg, with the blood flow restriction technique (80% of arterial occlusion pressure).
The invention relates to a medicament for treating diabetes which solves problems of lack effective medicament for treating diabetes in clinic. The medicament is prepared from raw materials by weight including: 50-100 parts by weight of pine pollen, 50-80 parts by weight of mulberry leaves, 10-50 parts by weight of tinospora root, 50-80 parts by weight of pueraria flower, 50-100 parts by weight of ginseng fruit, 50-80 parts by weight of astragalus. The pine pollen is broken wall pine pollen broken by wind tunnel. The raw material dry preparation by the weight ratio is prepared tablet, capsule, pill, powder, pellet, plaster after being crashing; or the raw material dry preparation by the weight ratio is prepared decoction using traditional method. The medicament is fine prepared from Chinese medical herbs selected from homeland medicament treasure-house that has advantages of clearing heat and promoting fluid, engendering fluid and quenching thirst, fortifying the spleen and dissipating dampness, promoting blood circulation by removing blood stasis, freeing qi-blood, strengthening metabolism, adjusting each large system function dual-way and longer. The directions for preparing the medicament has advantages of accurate and reasonable, low cost, better clinic effect, and suitable for patient with up, middle and down sanxiao diabetes. The medicament can balance yin-yang, promote blood circulation by removing blood stasis, activate life gate rise and fall function; soften blood vessel, reduce blood-fat, adjust whole body, help body recovering natural cure ability; improve body stuff all sides, relieve and eliminate diabetes and complicating disease. The medicament has advantages of effective curing diabetes and obvious curative effect.
The invention provides bionic antibacterial and antioxidant nano particles based on a pricklyash peel extract, and a preparation method and application thereof, and belongs to the technical field of medicine preparation. The invention provides a compound shown in a formula I, or a salt or stereoisomer thereof. The invention also provides a nanoparticle prepared from the compound shown in the formula I and the antibacterial peptide. The invention carries out hydroformylation on the compound extracted from the pricklyash peel to obtain a novel compound which has antioxidant capacity. The antibacterial peptide-compound nano particles prepared by mixing the compound with the antibacterial peptide have good biocompatibility and synergistic antioxidation and antibacterial capability. The nano particles can controllably release the antibacterial peptide according to the microenvironment of the wound, can effectively remove bacteria brought by infection and regulate the oxidative stress state of the wound, can promote the rapid healing of the wound, simultaneously play a role in promoting the healing of the wound in a synergistic way, and have important application prospect for clinically promoting the healing of the wound.
Patients receive paclitaxel IV over 1 hour once weekly for 3 weeks. Patients also receive oral sorafenib tosylate twice daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Open-label. Two sprays per nostril once daily (200 mcg/day). After 4 weeks, dose can be decreased to one spray per nostril daily or increased to 4 sprays per nostril daily.
A system and method for topically treating a wound or lesion of tissue to prevent infection includes applying nitric oxide gas to the wound or lesion. The basic system includes a source of nitric oxide gas and a flushing envelope. The flushing envelope is applied to a patient to cover a wound or lesion and receives nitric oxide from the source via a flow control valve. One form of the system also includes a vacuum unit fluidically connected to the flushing envelope, and one embodiment includes a gas absorber unit. The flushing envelope is adapted to surround the area of the infected tissue and form a substantially airtight seal with the tissue surface when the flushing envelope is in place on the patient. The flow control valve controls the amount of nitric oxide gas that is delivered to the flushing envelope. A source of dilutant gas is fluidically connected to the flow control valve and a system control unit transmits and receives signals from various sensors and controlled elements in the system. NO and NO 2  sensors are included in one form of the system.
AIM: To evaluate variation in magnetic resonance imaging (MRI) technique and reporting of rectal cancer staging examinations across the UK.
MATERIALS AND METHODS: A retrospective, multi-centre audit was undertaken of imaging protocols and information documented within consecutive MRI rectal cancer reports between March 2020 and August 2021, which were compared against American and European guidelines. Inclusion criteria included histologically proven rectal adenocarcinoma and baseline staging MRI rectum only.
RESULTS: Fully anonymised data from 924 MRI reports by 78 radiologists at 24 centres were evaluated. Thirty-two per cent of radiologists used template reporting, but these reports offered superior documentation of 13 out of 18 key tumour features compared to free-text reports including T-stage, relation to peritoneal reflection and mesorectal fascia (MRF), nodal status, and presence of extramural venous invasion (EMVI; p<0.027 in each). There was no significant differences in the remaining five features. Across all tumour locations, the tumour relationship to the MRF, the presence of EMVI, and the presence of tumour deposits were reported in 79.5%, 85.6%, and 44% of cases, respectively, and tumour, nodal, and distant metastatic stage documented in 94.4%, 97.7%, and 78.3%. In low rectal tumours, the relationship to the anal sphincter complex was reported in only 54.6%.
CONCLUSION: Considerable variation exists in rectal cancer MRI acquisition and reporting in this sample of UK centres. Inclusion of key radiological features in reports must be improved for risk stratification and treatment decisions. Template reporting is superior to free-text reporting. Routine adoption of standardised radiology practices should now be considered to improve standards to facilitate personalised precision treatment for patients to improve outcomes.
Classical Hodgkin lymphoma, INTERMEDIATE RISK will receive 2 cycles of brentuximab vedotin (Bv), doxorubicin, vinblastine, dactinomycin, and rituximab (Bv-AVD-R 1 and 2). Response assessment with FDG-PET scan after 2 cycles of Bv-AVD-R. Rapid early responders (RER) will continue therapy with 2 cycles of Bv, vinblastine, dactinomycin, nivolumab, and rituximab (Bv-NVD-R 1 and 2). RERs will not receive radiation therapy. Patients deemed to be Slow Early Responders (SER) after 2 cycles of Bv-AVD-R will continue therapy with 4 cycles of Bv-NVD-R (Bv-NVD-R 1, 2, 3, and 4). Radiation therapy will be given at completion of therapy only for SER patients NOT achieving complete remission at the end of chemoimmunotherapy.
BACKGROUND: Given the heightened risk of postoperative complications associated with obesity, delaying total hip arthroplasty (THA) in patients who have a body mass index (BMI) > 40 to maximize preoperative weight loss has been advocated by professional societies and orthopaedic surgeons. While the benefits of this strategy are not well-understood, previous studies have suggested that a 5% reduction in weight or BMI may be associated with reduced complications after THA.
METHODS: We identified 613 patients who underwent primary THA in a single institution during a 7-year period and who had a BMI >40 recorded from 9 to 12 months prior to surgery. Subjects were stratified into 3 cohorts based on whether their baseline BMI decreased by >5% (147 patients, 24%), was unchanged ( ± 5%) (336 patients, 55%), or increased by >5% (130 patients, 21%) on the day of surgery. The frequency of 90-days Hip Society and Centers for Medicare & Medicaid Services complications was compared between these cohorts. There were significant baseline differences between the cohorts with respect to baseline American Society of Anesthesiologists class (P < .001) and hemoglobin A1C (P = .011), which were accounted for in a multivariate regression analysis.
RESULTS: In univariate analysis, there was a lower incidence of readmission (P = .025) and total complications (P = .005) in the increased BMI cohort. The overall complication rate was 18.4% in the decreased BMI cohort, 17.6% in the unchanged cohort, and 6.2% in the increased cohort. However, multivariable regression analysis controlling for potential confounders did not find that preoperative change in BMI was associated with differences in 90-days complications between cohorts (P > .05).
CONCLUSIONS: Patients who have a BMI >40 and achieved a clinically significant (>5%) BMI reduction prior to THA did not have a lower risk of 90-days complications or readmissions. Thus, delaying THA in these patients to encourage weight loss may result in restricting access to a beneficial surgery without an appreciable safety benefit.
BACKGROUND: Female sexual function in pregnancy is an under-investigated topic by care providers. This study aimed to investigate the sexual function and the impact of traditional risk factors for pelvic floor disorders (PFDs) during the third trimester of pregnancy.
METHODS: This is a secondary analysis of a multicenter cross-sectional study conducted in eight hospitals in Italy and Italian-speaking Switzerland. Women at the third trimester of pregnancy aged 18 years and over completed the Italian-PFQPP questionnaire anonymously.
RESULTS: Overall, 927 patients in the third trimester of pregnancy answered the questionnaire. About 29.5% of women reported reduced or absent sexual activity. The less reported symptom was coital incontinence (1.3%), while painful intercourses was the most frequent one (50.3%). Nicotine abuse was associated with traumatic sexual intercourses, impaired vaginal sensibility, and negative impact on sexual life and well-being. Familiarity for pelvic floor disorder resulted as a risk factor for coital incontinence (OR=3.61).
CONCLUSIONS: Sexual symptoms, with pain during intercourses being the most widely reported, are extremely common in the third trimester of pregnancy and can greatly affect quality of life. Familiarity for pelvic floor disorders and nicotine abuse resulted as significant risk factors for at least one sexual symptom.
In the present invention, there is described a container comprising a canister sealed with a metering valve, having a metering chamber (4). The canister contains a pharmaceutical aerosol formulation consisting essentially of (A) particulate salmeterol xinafoate optionally in combination with fluticasone propionate suspended in (B) a liquefied propellant gas comprising 1,1,1,2,3,3,3-heptafluoro-n-propane, 1,1,1,2-tetrafluoroethane or a mixture thereof; wherein the formulation is substantially free of surfactant and components having polarity higher than the liquefied propellant gas. Said metering valve is characterized in that it contains a valve body (1) having an inlet port an outlet port and an opening/closing mechanism, which comprises a lower sealing basket (9) receiving a valve stem (7) having a dispensing passage. The valve stem (7) is slidably movable inside the sealing from a closed valve positron into an open valve positron, and the valve is sealed relative to the canister through the mediation of a gasket (3). At the same time the valve comprises one or more sealing gaskets (3, 9, 12) substantially constructed from more than 90 percent of a polymer of EPDM, wherein at least one gasket and (b) the metering chamber (4) surface present fluorinated surface to the formulation. There is also described a package comprising a metered dose inhaler and a canister according to the present invention.
Over 950 patients received Lotrel once-daily in 6 double-blind, placebo-controlled studies. The antihypertensive effect of a single dose persisted for 24 hours, with peak reductions achieved 2 to 8 hours after dosing.

Once-daily doses of benazepril/amlodipine using benazepril doses of 10 to 20 mg and amlodipine doses of 2.5 to 10 mg decreased seated pressure (systolic/diastolic) 24 hours after dosing by about 10–25/6–13 mmHg.

In 2 studies in patients not adequately controlled on either benazepril 40 mg alone (n = 329) or amlodipine 10 mg alone (n = 812) once-daily doses of Lotrel 10/40 mg further decreased seated blood pressure compared to the respective monotherapy alone.

Combination therapy was effective in blacks and nonblacks. Both components contributed to the antihypertensive efficacy in nonblacks, but virtually all of the antihypertensive effect in blacks could be attributed to the amlodipine component. Among nonblack patients in placebo-controlled trials comparing Lotrel to the individual components, the blood pressure lowering effects of the combination were shown to be additive and in some cases synergistic.

During chronic therapy with Lotrel, the maximum reduction in blood pressure with any given dose is generally achieved after 1 to 2 weeks. The antihypertensive effects of Lotrel have continued during therapy for at least 1 year. Abrupt withdrawal of Lotrel has not been associated with a rapid increase in blood pressure.
PURPOSE: This study sought to determine the predictive and prognostic value of clinicopathological parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hemoglobin (Hgb) level in predicting recurrence patterns and locoregional relapse-free survival (LRFS) and distant metastasis-free survival (DMFS) in cervical cancer patients receiving definitive chemoradiotherapy (ChRT).
METHODS: This study included 261 cervical cancer patients treated with ChRT. The primary endpoints were the predictors of local recurrence (LR) and distant metastasis (DM), whereas the secondary endpoints were LRFS and DMFS. The association of survival with potential prognostic factors was analyzed using Cox regression analysis, and the predictors of LR and DM were identified using logistic regression analysis.
RESULTS: The median follow-up time was 10.9 years. Recurrences occurred in 132 patients (50.6%) within a median of 11.2 months after definitive ChRT. NLR and PLR values were significantly higher in patients with LR and DM than in those without, with no significant differences in Hgb levels in patients with or without LR and DM. In the multivariable logistic regression analysis, lymph node metastasis, elevated NLR, and low Hgb level were significantly correlated with LR and DM. In the multivariable analysis, large tumor size, presence of lymph node metastasis, and elevated NLR were the independent predictors for poor LRFS and DMFS, and Hgb level was an additional prognostic factor for DMFS.
CONCLUSION: Hematological markers, particularly NLR and Hgb, may serve as cost-effective and readily accessible indicators for predicting recurrence and survival in cervical cancer patients, contributing to their practical use in routine assessments.
BACKGROUND: The prevalence and risk factors of posttraumatic stress disorder after cesarean delivery, outside high-risk contexts, remain unclear.
OBJECTIVE: This study aimed to assess posttraumatic stress disorder prevalence and risk factors at 2 months postpartum among a general population of women with cesarean delivery.
STUDY DESIGN: This was a prospective ancillary cohort study of the Tranexamic Acid for Preventing Postpartum Hemorrhage after Cesarean Delivery (TRAAP2) trial, conducted in 27 French hospitals from 2018 to 2020, enrolling women expected to undergo cesarean delivery before or during labor at ≥34 weeks of gestation. After randomization, characteristics of the cesarean delivery and postpartum blood loss were prospectively collected. Two months after childbirth, posttraumatic stress disorder profile (presence of posttraumatic stress disorder symptoms) and provisional diagnosis (positive screening for diagnosis consistent with a posttraumatic stress disorder) were assessed by 2 self-administered questionnaires (Impact of Event Scale - Revised and Traumatic Event Scale). The corrected posttraumatic stress disorder prevalence was estimated with inverse probability weighting to take nonresponse into account. Associations between potential risk factors and posttraumatic stress disorder were analyzed by multivariate logistic or linear regression modeling according to the type of dependent variable.
RESULTS: In total, 2785 of 4431 women returned the Impact of Event Scale - Revised questionnaire and 2792 the Traumatic Event Scale (response rates of 62.9% and 63.0%). The prevalence of posttraumatic stress disorder profile was 9.0% (95% confidence interval, 7.8%-10.3%) and of provisional diagnosis 1.7% (95% confidence interval, 1.2%-2.4%). Characteristics associated with a higher risk of posttraumatic stress disorder profile were prepregnancy vulnerability factors (young age, high body mass index, and African-born migrant) and cesarean delivery-related obstetrical factors (cesarean delivery after induced labor [adjusted odds ratio, 1.81; 95% confidence interval, 1.14-2.87], postpartum hemorrhage [adjusted odds ratio, 1.61; 95% confidence interval, 1.04-2.46] and high-intensity pain during the postpartum stay [adjusted odds ratio, 1.90; 95% confidence interval, 1.17-3.11]). Women who had immediate skin-to-skin contact with their newborn were at lower risk of posttraumatic stress disorder (adjusted odds ratio, 0.66; 95% confidence interval, 0.46-0.98), and women with bad memories of delivery on day 2 postpartum were at higher risk (adjusted odds ratio, 3.20; 95% confidence interval, 1.97-5.12). The Impact of Event Scale - Revised and the Traumatic Event Scale yielded consistent results.
CONCLUSION: Approximately 1 in 11 women with cesarean deliveries had posttraumatic stress disorder symptoms at 2 months postpartum. Some obstetrical interventions and components of cesarean delivery management may influence this risk.
Educational attainment (EA) is often used as a symbol of socioeconomic status and is associated with several diseases. However, uncertainty remains regarding the potential relationship between EA and chronic pain. This study aimed to evaluate the potential causal association between EA and chronic pain. The primary method employed in Mendelian randomization (MR) analysis was inverse-variance weighted method. Additionally, MR-Egger intercept, Cochran Q, and MR-PRESSO statistical analyses were conducted to assess potential pleiotropy and heterogeneity. The MR analysis provided evidence that genetically predicted additional education significantly reduced the risk of chronic pain. Specifically, this genetic factor may reduce multisite chronic pain by 27.6%, and chronic widespread pain by 3.8%. The results of sensitivity analysis indicated the reliability of our causal estimates. Higher levels of EA may provide protection against chronic pain risk. Enhancing education, narrowing social and economic disparities may help alleviate the burden of chronic pain.
The modified DBT protocol, developed by the principal investigator and co-investigators, which will be offered in an individual therapy format. It consists of 12 weekly individual sessions, each lasting 50-60 minutes. It is made based on the manual (Linehan 2015), retaining the essence of DBT (Linehan 1993), and remain dialectically focused. Each session focuses on specific skills within that content of modules.
Crystalline insulin preparations containing bases of the acridine or quinoline series, which bases, within a pH range of 6.5 and 9, are insoluble in water or only soluble to form a colloidal solution, or containing globin, histones, protamines, or their degradation products, for example proteoses and other basic polypeptides, are prepared by stirring insulin crystals with an aqueous solution containing a substance as specified above at about neutral reaction, e.g. pH7.2 while maintaining the pH by addition of alkali, e.g. sodium hydroxide.  The insulin crystals produced may be separated washed and dried.  Alternatively, the operation may be carried out under sterile conditions and the product obtained directly worked up into a suspension ready for use and containing for example isotonic sodium chloride. Specification 694,530 is referred to.
Newly synthesized gemini quaternary ammonium salts (QAS) with different counterions (bromide, hydrogen chloride, methylcarbonate, acetate, lactate), chain lengths (C12, C14, C16) and methylene linker (3xCH2) were tested. Dihydrochlorides and dibromides with 12 carbon atoms in hydrophobic chains were characterized by the highest biological activity against planktonic forms of yeast and yeast-like fungi. The tested gemini surfactants also inhibited the production of filaments by C. albicans. Moreover, they reduced the adhesion of C. albicans cells to the surfaces of stainless steel, silicone and glass, and slightly to polystyrene. In particular, the gemini compounds with 16-carbon alkyl chains were most effective against biofilms. It was also found that the tested surfactants were not cytotoxic to yeast cells. Moreover, dimethylcarbonate (2xC12MeCO3G3) did not cause hemolysis of sheep erythrocytes. Dihydrochlorides, dilactate and diacetate showed no mutagenic potential.