anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the recent years, technologies of genomics, expression analysis and proteomics have been brought to guide the study of risk assessment and early detection of cancers. This proposed study aims to develop a non-invasive DNA methylation-based assay system elucidating a panel of aberrantly hypermethylated genes from urothelial tumors and urine sediments, to improve the risk assessment of urothelial carcinoma; such as early diagnosis, prognosis, and prediction of response to therapeutic regimes. This proposal will establish several techniques to study the methylation status on gene promoter regions. Three tasks will be achieved in this study: (1) Profiling the aberrant DNA methylation in urothelial carcinoma and determining potential prediction biomarkers. (2) Establishing a non-invasive assay by detecting DNA hypermethylation status in exfoliated cells collected from void urine; (3) Mapping the DNA hypermethylation changes from normal to malignant urothelial tumors and studying the underlying mechanism. Through the collaboration of a genetic toxicologist (Te-Chang Lee, PhD, IBMS), a urologist (Yeong-Shiau Pu, MD/PhD, NTUH) and epidemiologists (Hung-Yi Chiou, PhD, Taipei Medical University), we will explore the risk biomarkers for urothelial carcinoma.
Revlimid is an important imid based therapy of myeloma. However patients will still relapse after this drug and then have limited options. Abraxane has shown efficacy in a number of cancers, putatively through intratumor concentration by SPARC (secreted protein acidic and rich in cysteine). (Taxanes have shown a modest activity in myeloma. Interestingly, Revlimid can upregulate the levels of SPARC. Thus, investigators will test the toxicity and efficacy of a combination of Revlimid and Abraxane in relapsed/refractory myeloma.

Investigators will perform a phase I/II trial of Revlimid daily for 21 days and Abraxane weekly for 3 weeks in patients who have failed Revlimid but have adequate blood counts and renal function and minimal neuropathy. For study purposes, 1 cycle is considered to be 4 weeks (20 days). Subjects will get Abraxane for three weeks and will be off of this treatment for 1 week. There are 10 visits per cycle. Accrual will be on standard 3 patient cohorts. Once the maximum tolerated dose is reached, the level below will be expanded to 25 patients for a pilot phase II trial. All treatments will be performed until progression. Assessments will be made at least at the 2, 4, and 6 month timepoints and monthly thereafter until progression.

Since both drugs can cause myelosuppression, investigators will start with doses below their standard doses as single agents. Investigators will use 100 mg/m2 of Abraxane weekly for 3 weeks and 10 mg Revlimid daily for 21 days, with a dose escalation for Revlimid to 15 mg and to 25 mg. Dose de-escalations will also be performed for both drugs as necessary. Investigators will explore whether SPARC (secreted protein acidic and rich in cysteine) expression is altered by flow cytometry and immunohistochemistry.
The invention belongs to the technical field of Chinese herbal medicine atomized products, and discloses a dried orange peel cough-relieving herbal atomized composition and a preparation method and application thereof. Is prepared from pure plant Chinese herbal medicines. It is pungent, bitter and warm in nature. It enters lung and spleen meridians as the therapeutic channel. The dried orange peel can regulate qi and invigorate spleen; honey pomelo contains abundant vitamin C; the grape seeds contain amino acids, vitamins and minerals; semen Ginkgo has effects of astringing lung and relieving asthma; lophatherum gracile has the effects of clearing heat and purging fire; the almond can relieve cough and asthma; the fingered citron eliminates dampness and phlegm; exocarpium Citri rubrum is used for eliminating dampness and phlegm; hyacinth dolichos flower has the functions of strengthening spleen and stomach; honey can moisten intestine and promote fluid production. The prescription is an integral prescription, and the prescription is helpful for relieving cough and asthma, nourishing yin and moistening dryness, regulating qi and relieving epigastric distention, eliminating dampness and reducing phlegm after being combined.
The results of autopsies performed in the pathological department of the Infectious Diseases Hospital named after. S.P. Botkin during the siege of Leningrad (from September 8, 1941 to January 27, 1944). The structure of diseases of the deceased varied during different periods of the siege of Leningrad. In the first period (September-December 1941), diphtheria, dysentery, measles, typhoid fever, and scarlet fever prevailed among the diseases. The most common causes of death in the second period (April-December 1942) were typhus, dysentery, tuberculosis, lobar pneumonia, and typhoid fever. Nosological structure in the third period of the blockade (January 1943 - January 1944): tuberculosis, dysentery, cachexia, lobar pneumonia, infectious jaundice. The discrepancy between clinical and morphological diagnoses is most often noted for the following nosology: pulmonary tuberculosis, typhoid fever, pneumonia, stomach and hepatopancreatobiliary cancer, measles, influenza. The first period of the blockade was distinguished by a high specific proportion of examination of children's bodies - 51.2% of all autopsies; in subsequent periods, the specific share of autopsies of deceased adults (20-59 years) increased to 76.2%. The difference in the nosological structure and age groups of those who died during different periods of the siege of Leningrad was determined by the epidemiological situation in the city, social and living conditions and medical and organizational factors. Conducted in the pathological-anatomical department of the hospital named after. S.P. Botkin during the siege of Leningrad, pathological studies made it possible to timely establish the causes of deaths and identify the peculiarities of the course of infectious diseases against the background of cachexia. Regularly held clinical and anatomical conferences contributed to the reduction of defects in the diagnosis and treatment of infectious diseases.
PURPOSE: To obtain a composition for intrabuccal use capable of exhibiting improved effect on anti-plaque and anti-gingivitis by compounding stannous fluoride with stannous gluconate and folic acid, in which the resultant compound further contains a support, has pH in a weak acidic region and is substantially free from Ca ion source. CONSTITUTION: This composition for intrabuccal use is obtained by compounding stannous fluoride with stannous gluconate and folic acid, respectively in a safe and effective amount, and the resultant compound contains a pharmaceutically permissible support. The composition has a pH of about 3.0 to about 5.5 and is substantially free from Ca source (about 2% or less). Especially, the contents of stannous fluoride, stannous gluconate and folic acid are about 0.05 - about 1.1wt.%, about 0.1 - about 11wt.% and about 0.01 - about 5.0wt.%, respectively. Examples of the support include a silica dental abrasive material. In this composition, stannous fluoride can exhibit improved effects and does not discolor. The composition further shows excellent anti-plaque and anti-gingivitis effects.
Eight patients underwent pars plana vitrectomy under local anesthesia. Vitrectomy used 3 23-gauge sclerotomies, triamcinolone for hyaloid cleaning, and hemostasis by elevated pressure, endo-diathermy, or laser. Panretinal laser applied to unlasered retina. Retina examined for tears or bleeding. IOP set at 20mmHg, sclerotomies sutured if needed.
Participants admitted with acute medical diseases to a conventional hospitalization unit will be included in a prospective registry in order to investigate the 90 days incidence of thromboembolic disease. A group of such patients will be controlled with triaxial accelerometer in order to collect raw data regarding patient mobility during admission.
Described herein are systems, methods, and programming to control light sources within a medical environment to avoid distracting a user (e.g., surgeon, nurse, medical staff, etc.) and/or inducing alarm fatigue. Some examples include determining that a setting of at least one light source of a medical environment is to be adjusted for use during a medical procedure. A determination may be made that the at least one light source is to be adjusted to a predefined setting associated with the medical procedure. The setting of the at least one light source may be adjusted to the predefined setting. This predefined setting may reduce the likelihood that the emitted light will distract the user while the medical procedure is being performed.
As the global population ages, understanding of the effect of aging on visual perception is of growing importance. This study investigates age-related changes in adulthood along size perception through the lens of three visual illusions: the Ponzo, Ebbinghaus, and Height-width illusions. Utilizing the Bayesian conceptualization of the aging brain, which posits increased reliance on prior knowledge with age, we explored potential differences in the susceptibility to visual illusions across different age groups in adults (ages 20-85 years). To this end, we used the BTPI (Ben-Gurion University Test for Perceptual Illusions), an online validated battery of visual illusions developed in our lab. The findings revealed distinct patterns of age-related changes for each of the illusions, challenging the idea of a generalized increase in reliance on prior knowledge with age. Specifically, we observed a systematic reduction in susceptibility to the Ebbinghaus illusion with age, while susceptibility to the Height-width illusion increased with age. As for the Ponzo illusion, there were no significant changes with age. These results underscore the complexity of age-related changes in visual perception and converge with previous findings to support the idea that different visual illusions of size are mediated by distinct perceptual mechanisms.
Age adjusted rates for overdose among women in the US increased more than six-fold from 1.4 in 1999 to 8.5 in 2016. Examining Pennsylvania (PA) and Utah (UT; the states where recruitment will happen in this study), these states have some of the highest rates of overdose among women compared to other US states. Specifically, PA's overdose rate among women surpassed the national average in 2016, and rates of overdose death in UT among women have ranged 2-9 times higher than the national rate between 2009 to 2016. Both PA and Utah are among the states with the highest opioid prescribing to pregnant women, with Utah being the highest in the nation (41.6%). Prenatal opioid use disorder (OUD) in the US has brought serious health consequences for mother and infant-including preterm delivery, low birth weight, NAS, and poor breastfeeding, and includes substantial expenditures of health care resources. Chances for HIV (OR=20.3, 95% CI = 13.8-29.7) and hepatitis C virus (OR=150.2. 95% CI = 120.9-186.6) infection among women with OUD are markedly higher than for those without OUD. Pregnant women with OUD have high rates of psychiatric illnesses, such as depression and anxiety, and other substance use disorders (SUDs), with particularly high rates of smoking (\>80%). Neonatal abstinence syndrome (NAS), an opioid withdrawal syndrome among neonates, has also increased substantially from 3.4/1000 births in 2009 to 5.8/1000 births in 2012. Poly-substance use among pregnant women with OUD has also been associated with higher levels of needed medications to treat NAS and longer duration of NAS treatment. Smoking combined with opioid use during pregnancy has likewise been related to longer duration of NAS treatment, greater NAS severity, and higher levels of medication needed to treat NAS symptomology. Any prenatal opioid use also has been associated with birth defects, including neural tube defects, conoventricular septal defects, atrioventricular septal defects, hypoplastic left heart syndrome, and gastroschisis. Compared with women without any SUDs, children born to mothers with OUD or OUD plus other SUDs also have been documented to have lower cognitive functioning as they mature. Problems resulting from illicit and prescription OUD also result in significant social issues. Pregnant women with OUD have been observed to have financial and housing instability, challenges related to employment, and involvement with the legal system.
Small RNAs are widely involved in plant immune responses. However, the role of long small RNAs (25 to 40 nt) in monocot plant disease resistance is largely unknown. Here, we identified a long small RNA (lsiR76113) from rice (Oryza sativa) that is downregulated by Magnaporthe oryzae infection and targets a gene encoding CYCLIC NUCLEOTIDE-GATED CHANNEL 5 (CNGC5). The cngc5 mutant lines were more susceptible to M. oryzae than the wild type, while knocking down lsiR76113 in transgenic rice plants promoted pathogen resistance. A protoplast transient expression assay showed that OsCNGC5 promotes Ca2+ influx. These results demonstrate that OsCNGC5 enhances rice resistance to rice blast by increasing the cytosolic Ca2+ concentration. Importantly, exogenous Ca2+ application enhanced rice M. oryzae resistance by affecting reactive oxygen species (ROS) production. Moreover, cngc5 mutants attenuated the PAMP-triggered immunity response, including chitin-induced and flg22-induced ROS bursts and protein phosphorylation in the mitogen-activated protein kinase cascade, indicating that OsCNGC5 is essential for PAMP-induced calcium signaling in rice. Taken together, these results suggest that lsiR76113-mediated regulation of Ca2+ influx is important for PTI responses and disease resistance in rice.
PURPOSE: A method for manufacturing a hair growth promoting agent is provided to promote blood circulation and metabolism, to prevent alopecia, and to promote hair growth. CONSTITUTION: A method for manufacturing a hair growth promoting agent comprises: a step of preparing medicine ingredients including Rumex japonicus HOUTT, Pleuropterus multiflorus, safflower, Cnidium officinale, Mentha Arvensis var. Piperascens, ASICASARUM sieboldi F. Maekawa, and Glycyrrhiza uralensis Fischer(110); a step of putting the medicine ingredients and purified water and heating at 2kgf/cm^2 and 80-90°C(120); a step of placing the mixture by zero pressure and temperature; a step of heating the mixture at 80-90 Deg. C. for 1-2 hours; a step of maturing at 7-8 Deg. C. for 12 hours; a step of heating at 80-90 Deg. C. and 2kgf/cm^2 for 2-3 hours; a step of filtering and extracting the mixture; a step of stirring the extract well and evaporating(130); and a step of adding refined horse milk and re-heating at 70-80 Deg. C. for 0.5-1 hours(140,150).
<P>PROBLEM TO BE SOLVED: To obtain a precious metal coated pigment having an excellent performance in a coloring property, strong durability and successful heat conductivity in which color is not dropped off against water and an oil and reduction of safety by a protective colloid component or the like can be prevented, and to prepare its formulated cosmetic.  <P>SOLUTION: The precious metal coated pigment is obtained by coating the pigment with the precious metal colloid and burning it. The precious metal includes gold, silver, platinum and palladium. Among of them, gold, silver and platinum are preferable and gold colloid in which the particle is fine and spherical and the color is red-based and is easily used is particularly preferable. The precious metal used is in the colloidal state.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
Non-communicable diseases (NCDs) account for 71% of all annual deaths, totaling 41 million people worldwide. The development and progression of these diseases are highly related to the environment and lifestyle choices, among which physical inactivity and excess malnutrition stand out. Currently, in Chile, there is no evidence at the regional and local level on the impact of physical activity and healthy nutrition plans and interventions on health promotion, prevention, and timely treatment of NCDs. The following protocol delineates the URO/FOCOS (Universidad Regional de O'Higgins/FOrtaleciendo COmunidades Saludables- Regional University of O'Higgins/Strengthening Healthy Communities) study, which will assess pilot community intervention strategies using a participatory action research approach by identifying barriers and facilitators on the practice of physical activity and healthy eating habits. In this project, the community from the O'Higgins region will be involved throughout the entire research process to develop strategies that promote regular physical activity and healthy eating practices. We propose three interrelated strategies: (1) Participatory Action Research, (2) Community interventions for promoting physical activity and healthy nutrition practices, and (3) health education. The URO/FOCOS study offers a unique opportunity in the O'Higgins region to develop participatory strategies and interventions based on the community's needs and motivations with regard to physical activity and healthy eating habits. We believe these strategies will help to improve the community's overall health through effective changes in their decision and preferences toward a more active lifestyle and healthier nutrition practices.
Arm 1 is the control arm. This arm will receive the standard cardiopulmonary bypass circuit.
Intervention. Drug: Desflurane. Desflurane 8 vol% anesthesia is introduced. This provides complete suppression of animal responses to pain, fixation, tracheal intubation and cardiac arrest. After fixation of the animal in the supine position trachea is intubated and mechanic ventlation with air using an animal respirator is performed. Surgery: Cardiac arrest is induced by intrathoracic clamping of the supracardiac bundle of vessels by means of a special hook. Period of cardiac arrest and absence of ventilation lasts 10 min. The animal is then resuscitated by means of chest compressions and mechanichal ventilation with air. Cardiac activity and systemic blood circulation recovers within 1 min; spontaneous respiration will be resumed after a period of 4-6 min.
The invention discloses a traditional Chinese medicine foot bath health care prescription for treating eczema of scrotum. The foot is very critical to the health of human. The prescription comprises the following nine raw materials in parts by weight: 30 to 40 grams of sophora flavescens, 30 to 40 grams of fructus cnidii, 30 to 40 grams of radix clematidis, 10 to 15 grams of pericarpium zanthoxyli, 10 to 15 grams of alum, 10 to 15 grams of cyperus rotundus, 10 to 15 grams of dahurian angelica root, 10 to 15 grams of asarum herb, and 10 to 15 grams of shaved cinnamon bark. The preparation and application method comprises the following steps: cutting raw materials, pouring the raw materials into a marmite, adding 1000 to 1200 mL of water, decocting the raw materials for about 30 to 40 minutes, pouring the decoction into a nonmetal foot basin, and adding 3 to 5 kilograms of hot water, which is boiled for twice, is cooled once, and has a temperature of 38 to 40 DEG C, until the water soaks the ankle joints. The foot bath usually lasts for a half hour. People can sit on the foot basin to soak scrotum into the water, and the effect is better. The treatment course is one to two times a day, and lasts for 3 to 5 days. The prescription can treat eczema of scrotum.
PURPOSE: To obtain a zinc oxide-coated body pigment useful as a raw material, etc., for cosmetics by subjecting a plate-like zinc oxide to sticking treatment onto the surface of the body pigment. CONSTITUTION: This zinc oxide-coated body pigment is obtained by subjecting a body pigment to acid treatment and alkali treatment in the presence of a plate-like zinc oxide so that the plate-like zinc oxide is stuck onto the surface of the body pigment. The plate-like zinc oxide in the zinc oxide-coated body pigment is used in an amount of 0.1-50 wt.% and the body pigment is used in an amount of 50-99.9 wt.%. Since the plate-like zinc oxide excellent in ultraviolet light-scattering ability is uniformly subjected to sticking treatment onto the surface of the body pigment, the zinc oxide-coated body pigment has excellent ultraviolet-scattering ability. When the body pigment, is formulated into a cosmetic, excellent sunscreening effect is imparted to the cosmetic without formulating a large amount of an organic ultraviolet light absorbent therein.  The cosmetic can be prepared as foundation in the form of powder, cake, milk lotion, etc., rouge, eye shadow, face powder, makeup ground, anti-suntan cream, lotion, etc.
Charts for 462 subjects will be reviewed from 2002-2005 based on the surgery performed. From each chart, the subject name, date of birth,and social security number will be recorded along with the state of residence and year of surgery. This information will be transferred to a CD that is encrypted and password protected. The CD will be sent via FedEx overnight to the Center for Disease Control(CDC), National Death Registry. The CDC will use the information on the CD to extract death outcomes for each subject's information provided. Once all information is complete, the CDC will transfer on to a CD that is encrypted and password protected and return to our office via FexEx overnight. The information on the CD will then be used to determine what the long term death rates were for subjects here at SUNY Upstate Medical University and stored in an anonymous database. Once the information is verified as accurate, the CD will be destroyed and no identifying information will be kept. The CDC will also destroy the information after 60 days, with no links to the identifying information.
A single arm study to evaluate the effectiveness of a 2mm Raindrop Near Vision Inlay for the treatment of presbyopia in pseudophakic subjects. This corneal inlay is placed under a LASIK flap or in a corneal pocket, and is designed to change the anterior curvature of the cornea, resulting in the ability to reduce spectacle dependency for near and intermediate tasks.