anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To improve oil absorptivity by drying a silica hydrogel obtained by the reaction of an alkali metal silicate having SiO2 of a specific conc. or below with a mineral acid at the critical temp. or above of a solution. CONSTITUTION:A mineral acid such as sulfuric acid is added into an aq. alkali metal silicate solution such as Na2SiO3 adjusted to >=60g/l SiO2 conc. by diluting with water at a prescribed temp. A SiO2 slurry produced by aging at the temp., raising the temp. and furthermore adding the mineral acid is adjusted in pH, is filtered, washed and suspended again in water. By-product Na2SO4 is removed by refilteration and washing to obtain a hydrogel. By suspending the hydrogel in a solvent such as methanol, filtering and cleaning, a silica methanogel is obtained. The silica methanogel is suspended in a solvent such as methanol, is heated up to the critical point of the solvent (Tc=240 deg.C, Pc=78.7atm) and is cooled to obtain the high-oil-absorptive porous SiO2 having >=350ml/100g oil absorption and >=5ml/g narrow pore volume by the mercury porosimeter.
Omarigliptin 25 mg administered orally once weekly for 52 weeks (24 weeks during Phase A and 28 weeks during Phase B). Participants continued pre-study basal medication of BGs throughout the duration of the study.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline and the accumulation of amyloid-beta plaques, tau tangles, and neuroinflammation in the brain. Postoperative cognitive dysfunction (POCD) is a prevalent and debilitating condition characterized by cognitive decline following neuroinflammation and oxidative stress induced by procedures. POCD and AD are two conditions that share similarities in the underlying mechanisms and pathophysiology. Compared to normal aging individuals, individuals with POCD are at a higher risk for developing AD. Emerging evidence suggests that astrocytes, the most abundant glial cells in the central nervous system, play a critical role in the pathogenesis of these conditions. Comprehensive functions of astrocyte in AD has been extensively explored, but very little is known about POCD may experience late-onset AD pathogenesis. Herein, in this context, we mainly explore the multifaceted roles of astrocytes in the context of POCD, highlighting their involvement in neuroinflammation, neurotransmitter regulation, synaptic plasticity and neurotrophic support, and discuss how POCD may augment the onset of AD. Additionally, we discuss potential therapeutic strategies targeting astrocytes to mitigate or prevent POCD, which hold promise for improving the quality of life for patients undergoing surgeries and against AD in the future.
This meta-analysis aimed to investigate the effects of the enhanced recovery after surgery (ERAS) nursing program on surgical wound infection (SWI) and postoperative complications in patients undergoing total knee arthroplasty (TKA). The PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure and Wanfang databases were searched from the date of establishment of the database until August 2023 for randomised controlled trials (RCTs) that assessed the effects of the ERAS nursing program on SWI and postoperative complications in patients undergoing TKA. The literature was screened, data were extracted by two independent investigators, and the literature quality was assessed using the methods recommended by the Cochrane Collaboration. Data analysis was performed using Stata 17.0 software. Nineteen RCTs with 1580 patients were included in the study. The meta-analysis results showed that the rates of SWI (odds ratio [OR] = 0.19, 95% confidence interval [CI]: 0.10-0.37, p < 0.001) and postoperative complications (OR = 0.18, 95% CI: 0.12-0.25, p < 0.001) were significantly lower in the ERAS intervention group than those in the control group. Therefore, ERAS intervention after TKA can significantly reduce the occurrence of SWI and postoperative complications. It has a remarkable rehabilitation effect and can be widely used in clinical settings.
Documented cases of ipsilateral ptosis caused by midbrain infarction remain rare. Herein, we present a patient with isolated ipsilateral ptosis that was initially considered to be a consequence of myasthenia gravis but was subsequently attributed to ventral midbrain infarction. We also discuss the possible underlying mechanisms; ipsilateral ptosis in our patient was attributed to selective damage of the levator palpebral muscle branch of the oculomotor nerve. The patient was started on aspirin (200 mg once daily) and atorvastatin (40 mg once daily). Improvement in ptosis occurred from day 5 of admission, and the patient was subsequently discharged. Ptosis disappeared 1 month after onset. This report describes an extremely rare case of ventral midbrain infarction presenting with isolated ipsilateral ptosis. Careful examination, including magnetic resonance imaging, is essential in such patients, especially in those with multiple cerebrovascular risk factors.
Individuals will receive bright blue light therapy using glasses developed by AYO. During treatment blocks for bright blue light therapy, participants will receive a text message within an hour of their self-reported wake time instructing them to use their designated light therapy device for 30 minutes. Bright blue light therapy will be administered in 2 treatment periods each 2 weeks in length (4 weeks total). Bright blue light treatment has been previously identified as an efficacious treatment for fatigue. It has also been shown in a number of studies that the blue wavelength of light is a key component to the shift of fatigue measures in patient reported outcomes.
The endosomal sorting complex required for transport (ESCRT) machinery is composed of an articulated architecture of proteins that assemble at multiple cellular sites. The ESCRT machinery is involved in pathways that are pivotal for the physiology of the cell, including vesicle transport, cell division, and membrane repair. The subunits of the ESCRT I complex are mainly responsible for anchoring the machinery to the action site. The ESCRT II subunits function to bridge and recruit the ESCRT III subunits. The latter are responsible for finalizing operations that, independently of the action site, involve the repair and fusion of membrane edges. In this review, we report on the data related to the activity of the ESCRT machinery at two sites: the nuclear membrane and the midbody and the bridge linking cells in the final stages of cytokinesis. In these contexts, the machinery plays a significant role for the protection of genome integrity by contributing to the control of the abscission checkpoint and to nuclear envelope reorganization and correlated resilience. Consistently, several studies show how the dysfunction of the ESCRT machinery causes genome damage and is a codriver of pathologies, such as laminopathies and cancer.
DOSAGE MUST BE INDIVIDUALIZED AND MONITORED DURING UP-TITRATION. Treatment with COREG may be started as an inpatient or outpatient and should be started after the patient is hemodynamically stable and fluid retention has been minimized. It is recommended that COREG be started at 6.25 mg twice daily and increased after 3 to 10 days, based on tolerability, to 12.5 mg twice daily, then again to the target dose of 25 mg twice daily. A lower starting dose may be used (3.125 mg twice daily) and/or the rate of up-titration may be slowed if clinically indicated (e.g., due to low blood pressure or heart rate, or fluid retention). Patients should be maintained on lower doses if higher doses are not tolerated. The recommended dosing regimen need not be altered in patients who received treatment with an IV or oral β-blocker during the acute phase of the myocardial infarction.
Patients receive a welcome package with exercise equipment and participate in virtual-exercise sessions over 60-90 minutes weekly for 6 weeks. Participants are also receive access to optional drop-in classes, monthly newsletters and online fitness buddy matching program and are encouraged to participate in a walking program on study.
Study participants, while being stabilized on buprenorphine, will download and engage with the developed mHealth application, completing daily electronic sleep diaries for the next 6 weeks. Each week, they will be asked to complete a short assessment of their experiences from the previous week and their current insomnia severity.
Extensor mechanism (EM) disruption after total knee arthroplasty (TKA) is devastating, especially in cases of re-rupture. A 67-year-old man with diabetes had patellar tendon rupture after revision TKA and then had migration of the bone block after Achilles tendon allograft with bone block (ATBB) augmentation with cerclage. A third reconstruction was performed with open reduction and internal fixation and high-strength braided suture augmentation. Five months postoperatively, the patient had regained full range of motion with intact EM and hardware. The risk of re-rupture is high in ATBB, and the primary issues in this case were nonunion and tendinous compromise. A construct that encompasses compression and buttressing of the bone block with tendon augmentation potentially addresses the risks of recurrent EM rupture in more complex cases. [Orthopedics. 2024;47(5):e273-e276.].
NEW MATERIAL:A compound of formula I (R1 is H or hydroxyl group; R2 and R3 are H or lower alkyl and both or either one of R2 and R3 represents H) and a salt thereof. EXAMPLE:Xestospongin A of formula II. USE:Useful for treating a wide range of cardiac infarction, hypertension, angina pectoris and cerebral circulatory disorder, etc., and having vasodilator action. PREPARATION:A sponge is frozen with liquid nitrogen or air, and crushed at <=-150 deg.C to give a finely divided material, which is then extracted with an organnic solvent, e.g. benzene, at room temperature or below, The resultant extract is then concentrated and fractionated by the adsorption chromatography, etc. and purified to afford the aimed compound of formula I .
Pre-test data for all participants before treatment in the waiting room of the hemodialysis unit, "Structured Patient Introduction Form" (Annex-1), "Dialysis Symptom Index (DSI)" (Appendix 2), "Vital Signs Monitoring Form" (Appendix). 3),''Hemodialysis Comfort Scale Version II'' (Appendix 4) face to face interview for approximately 15 minutes is run as learning pre-test data. The intervention group was also given information about the use of virtual reality and the video content to be watched. Videos are transferred to virtual reality glasses and presented with the headset. After the hemodialysis treatment starts, the intervention psychologist researcher will watch 30 scan videos of approximately half an hour during the dialysis period, 2 sessions a week for 8 weeks, and a Turkey promotional short film presented by the researchers visually and audibly in VR (VR Shineco 3d).
Soft capsulated compositions containing on aqueous medicament, consist of a water-in-oil emulsion enclosed in a soft capsule, the emulsion and the continuous oil phase having a viscosity such that migration of the globules of the water phase is substantially prevented at the storage temperature used for the capsule.  The viscosity of the emulsion is at least 6000 cps. at 20 DEG C. at a shear rate of 1 sec-1. and that of the oil and that of the oil phase is at least 100 cps. at 20 DEG C. at high shear rate. Suitable oils are minerals oils, preferably liquid paraffin; vegetable oils such as arachis, olive, sesame, soya bean, castor and cattonseed oils; oily esters such as ethyl oleate, dilutyl sebacate, or isoamyl salicylate; or a suitable silicone oil.  If required, thickening agents, such as soft yellow or white paraffin, hard paraffin, beeswax, wool fats and alcohols, micro-crystalline paraffin hydrocarbons, vegetable stearines, hydrogenated vegetable fats, ethyl cellulose, or polyvalent metal, soaps, may be included to give the aid phase the necessary shear rate.  Also emusifying agents, preferably of the non-ionic type, may be added the capsule compositions are particularly suitable for making up aqueous oral vaccines.
1,215,485. Dentures. B. F. REGAN. 23 Jan., 1968, No. 3620/68. Heading A5R. [Also in Divisions C6 and C7] Metal backbones of dentures are produced by electroforming on a replica of the mouth a first layer of a metal which is compatible with body tissue, a second layer of a substantially unstressed metal which is stronger than the first metal, and a third layer of a metal compatible with body tissue, and thereafter removing the electro-deposited layers from the replica. Prior to electrodeposition the replica may be sealed with a solution of polyvinyl chloride, and made electrically conductive by coating with silver paint or by chemical reduction of a layer of silver, copper or nickel on said surface. The tissue compatible material may be of gold, rhodium or chromium, and the unstressed layer may be of nickel, and the layers may be separated by further layers of silver or tin-nickel alloy. During deposition of the second layer part of the surface, e.g. adjacent the finishing line of the denture backbone, may be mashed to produce cavities in the metal backbone, to which the plastics material resembling the user's gums may be secured.
INTRODUCTION: Rotavirus is a leading cause of severe diarrheal disease and death in children under five years of age worldwide. Vaccination is one of the most important public health interventions to reduce this significant burden.
AREAS COVERED: This literature review examined vaccination coverage, hospitalization rate, mortality, genotypic distribution, immunogenicity, cost-effectiveness, and risk versus benefit of rotavirus vaccination in children in South America. Nine out of twelve countries in South America currently include a rotavirus vaccine in their national immunization program with coverage rates in 2022 above 90%.
EXPERT OPINION: Introduction of the rotavirus vaccination has led to a marked reduction in hospitalizations and deaths from diarrheal diseases in children under 5 years, particularly infants under 1 year, in several South American countries. In Brazil, hospitalizations decreased by 59% and deaths by 21% (30-38% in infants). In Peru, hospitalizations in infants fell by 46% and deaths by 37% (56% in infants). Overall, data suggest that rotavirus vaccination has reduced rotavirus deaths by 15-50% in various South American countries. There is some evidence that immunity wanes after the age of 1-year old. Ongoing surveillance of vaccine coverage and changes in morbidity and mortality is important to maximize protection against this disease.
Patients without colorectal adenocarcinoma, but carrying high-risk adenomatous polyps being described by one of the following: 1) size≥1 cm; 2) high-grade dysplasia; 3) villous component. Prior to removal of the lesions.
PURPOSE: An organic UV agent-supported functional PMMA complex pigment is provided to minimize direct contact of agent with skin and prevent skin trouble and allergy. CONSTITUTION: A functional PMMA complex pigment contains 60-99.8 wt% of porous sphere and 0.20-40.0 wt% of organic UV agent. A cosmetic composition for UV protection contains 3-40 wt% of the functional PMMA complex pigment, 6-15 wt% of oil ingredient, 40-86 wt% of pigment, and 0.5-5.0 wt% of additives. The oil ingredient is hexyl laurate, cyclomethicone, scualene or dimethicone, or ester oil or silicon oil. The pigment includes ferric oxide, alumina, talc, silica, titanium dioxide, or polyethylene powder. The cosmetic composition is manufactured in the form of a powder pact, face powder, eye shadow, blusher, pencil, lip stick, mascara, or nail enamel.
PROBLEM TO BE SOLVED: To obtain a medicine high in safety and effective for preventing or treating hepatitis or liver damages such as viral hepatitis, medicine-induced hepatitis and alcoholic hepatitis by including an alkaloid extracted from Gynura segetum (Lour.) Merr. as an active ingredient. SOLUTION: This hepatitis or liver damage-preventing or treating medicine contains an alkaloid comprising senecionine or seneciphylline extracted from Gynura segetum (Lour.) Merr. as an active ingredient. A medicine composition comprises an effective amount of the alkaloid and, if necessary, a carrier, a diluent, etc. The alkaloid originated from the Gynura segetum (Lour.) Merr. is obtained by thermally extracting (A) the roots of the Gynura segetum (Lour.) Merr., preferably their powder, with (B) an alcohol containing <=10vol.% of water in an amount of 5-10 fold-amount that of the powder of the component A at a temperature above room temperature, preferably >=50 deg.C, and, if necessary, purifying the extract.
Placebo treatment after receiving Bevacizumab for 12 to 15 months. Cycles continue until disease progression and/or death, unacceptable adverse event/s, patient and/or investigator decision, other protocol stopping criteria.
Imaging and staging of prostate cancer is critical for surgical and treatment planning. Patients with suspected metastatic prostate cancer will be imaged using Gallium-68 labeled PSMA-11 in order to demonstrate its utility. The investigators plan to utilize this data to obtain further approvals of the Ga-68-PSMA-11 compound, so that this agent will become available for clinical imaging in prostate cancer patients. In the pre-prostatectomy population, the primary objective is to determine the sensitivity and specificity for detection on nodal metastasis.

This compound has been shown to be superior to choline based PET agents for the staging of prostate cancer, both Carbon-11 and Fluorine-18 compounds. But this compound was not patented and therefore no company or private entity will make the investment required to bring Ga-68-PSMA-11 to market. In the vacuum of availability, academic groups must take the lead in order to collect the necessary data for future FDA approval.
334,898. Groves, W'. W., (I. G. Farbenindustrie Akt.-Ges.). June 11, 1929. Hormones. - The hormones or active substances present in the, posterior lobe of the hypoplysis are extracted and separated into those which act on the uterus and those which increase the blood pressure. The fresh or dried gland is extracted with methyl or other alcohol containing hydrochloric sulphuric or other inorganic acid. The extract is precipitated either by neutralizing the acid by means of methyl alcohol containing ammonia or by addition of ether or other organic precipitant. The precipitate is dissolved in acidified alcohol and the solution is precipitated fractionally with acetone and ether, the first fractions containing more of the substances which act on the blood pressure- The filtrates containing the substances which act on the uterus are concentrated while feebly acid, shaken with water to form two layers, and the hormone obtained by distilling the alcohol from the aqueous layer and precipitating with petroleum ether. Alternatively the original extract may be precipitated first with acetone and then with ether.
For the ESP block, the transducer will be placed parasagittally at the level of the tip of the scapula and the anesthesiologist will scan in a craniocaudal manner to identify the ipsilateral T10 transverse process and overlying erector spinae muscle. Following aseptic preparation of the injection site and the ultrasound probe, a 22-gauge, 10mm block needle will be introduced parallel to the ultrasound guided beam (in-plane technique) until its tip reaches the plane between the erector spinae muscle and transverse process. After negative aspiration, 20 ml of a mixture containing 10ml 0.25% bupivacaine and 10ml 1.3% liposomal bupivacaine will be injected in 5 ml increments to separate the fascial plane between the muscle and transverse process. The investigators will observe local anesthetic spread under real-time imaging. The block will then be performed in the same manner on the opposite site.
The subject invention pertains to a feline-derived IL-2 independent T cell line that is susceptible to infection by at least one FIV subtype, the subtype selected from the group consisting of A, B, C and D.  The cell is designated FeT-1C ATCC accession no. CRL 11968. Also claimed are feline-derived T cell lines Fe-T-J, ATCC accession no. CRL 11967, Shi/FeT-1C ATCC accession no. 11976 and Bang/FeT-1C ATCC accession no. 11975.
Adjuvants are components of vaccines that boost the intensity, duration, and breadth of the immune response. Insight into the mechanisms responsible for the immunotoxicity of both local and systemic adverse reactions following the use of adjuvants has been gained through research over the past twenty years. In the present study, single and repeated-dose toxicity and local tolerance of newly developed Water-in-Oil (W/O) and Water-in-Oil-in-Water (W/O/W) Emulsion adjuvants (Coralvac RZ 528, Coralvac RZ 506, Coralvac AT 318, Coralvac AT 318 SIS and Coralvac 252) by Coral Biotechnology Industry and Trade Incorporated Company were demonstrated after intramuscular injection in mice. In both toxicity studies, no adverse reactions such as death, general appearance, behavior, or weight loss were observed in the mice in the experimental groups. The results indicate that clinical chemistry parameters demonstrated normal function of the major organs and no irreversible damage to the mice in all adjuvant groups compared to the control group. In histopathologic investigation of single dose toxicity study, inflammation, edema, and large amounts of lipid droplets were observed on the 7th day in all experimental groups. On the 14th day, when the control group and the experimental groups were compared, it was seen that inflammation and edema had decreased considerably. Similarly, repeated dose toxicity study showed mild inflammation and edema in the control group, while quite widespread and severe inflammation, edema, and diffuse lipid droplets of varying sizes were observed in all adjuvant groups compared to the control group. These observations would be useful for the future development of oil-based adjuvants and their use in veterinary inactive vaccines.
After baseline and 3 month imaging is completed. The waitlist control subgroups will be included in fMRI scans performed during the initial evaluation period (pre) and at 3 months (post). Subgroup I of 30 subjects will undergo fMRI scans that will include structural imaging and functional imaging with Blood Oxygen Level Dependent (BOLD) scan and two arterial spin labeling (ASL) scans. a typical morning waking up). This same imaging protocol, will be performed initially and then after the 3 month waitlist period. All scans will be co-registered and comparable slices of the cerebral cortex will be examined. After the waitlist imaging is completed the subjects will be offered the TaVNS health device.
Anterior cruciate ligament injury is a common neuromuscular injury to the knee joint. The incidence rate is gradually increasing. There are 400,000 ACL reconstruction operations in the United States every year. The population of my country is equivalent to 4.3 times that of the United States. The potential economic burden of cruciate ligament reconstruction surgery on the country cannot be ignored. Anterior cruciate ligament reconstruction is seen as an effective treatment for this disease, avoiding secondary meniscus damage and knee degeneration, but the failure rate is still as high as 20%. In addition, problems such as poor bending angle caused by postoperative adhesions that may occur after surgery, atrophy of the quadriceps muscle of the patient's affected leg, and overstrain of the healthy leg caused by psychological factors may affect the quality of life after surgery. Reasons that prevent return to sports. The use of conservative treatment instead of surgery after recent ACL injury has received high attention, and a large number of RCTs have compared the benefits of surgery and conservative treatment.

Some reviews pointed out that the clinical outcomes of surgical treatment and conservative treatment are not much different, and even questioned the prognosis after anterior cruciate ligament reconstruction. Individual differentiated treatment is necessary.