anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses medicine for regulating human body fluid qi quality and a preparation method thereof, particularly a ripeness agent and a scavenging agent for abnormal black balliary matters and a preparation method of the ripeness agent and the scavenging agent. The ripeness agent is proportionally prepared from 10 kinds of medicinal materials, such as paniculate microcos, toothedfruit dock leaf, liquorice, capillaire, humifuse euphorbia herb, etc., which are processed through decoction, soakage, filtration and dilution, and then, the 10 kinds of medicinal materials are prepared into patent medicine. The scavenging agent is proportionally prepared from 21 kinds of medicinal materials, such as clearing euchresta japonica, manna, cuscuta, fructus terminaliae, senna leaf, etc., which are successively added and processed through decoction, soakage, still standing, redecoction, filtration and dilution according to the different characteristics of the medicinal materials and technological requirements. The 21 kinds of medicinal materials are prepared into patent medicine. The present invention has the advantages of unique prescription, unique preparation method and unique curative effect. Abnormal black balliary matters in human bodies causing diseases are firstly ripened and accumulated, and then, are expelled out of bodies so as to restore qi quality and balance body fluid, which lays a foundation to the cure of stubborn diseases, such as high blood pressure, rheumatoid arthritis, psoriasis, vitiligo, asthma, tumours, etc., caused by human body fluid qi quality maladjustment.
BACKGROUND: Rhinoplasty is a common surgical procedure used in nose esthetics and pathologies. Shaping the nasal bones is a crucial step in achieving successful rhinoplasty surgery. However, complications such as excessive bleeding, edema, mucosal damage, and periosteal damage may occur during osteotomy for nose shaping.
AIM: To investigate the damage to soft tissue and the effects on oxidative stress and proinflammatory cytokines in the blood caused by osteotomy performed on rabbits, using different osteotomy methods. Methods: Thirty-two albino New Zealand rabbits were divided into four groups. Group A was the sham group (n = 8), Group B the piezoelectric device group (n = 8), Group C the manual saw group (n = 8), and Group D the classical osteotomy group (n = 8). About 3 ml of blood was drawn to compare preoperative and postoperative interleukin-1ß (IL-1ß), thiobarbituric acid-reactive substances (TBARS), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), interleukin-10 (IL-10), and glutathione (GSH) levels. A 1 mm3 piece of soft tissue from the nasal bone of each animal in the study groups was sent for histopathological examination. The Chi-square test was used to analyze the incidence of postoperative necrosis, inflammation, and edema in the groups.
RESULTS: Histopathologically, edema was significantly higher in Group C and Group D compared to Group B. Inflammation was increased in all groups. The necrosis was significantly higher in Group B compared to Group C and Group D. Except for two parameters, no significant changes were found in the biochemical markers for all groups.
CONCLUSIONS: The piezoelectric device was found to be a better option for reducing edema and inflammation, while manual saws and classical osteotomy may lead to more tissue damage.
OBJECTIVES: To investigate factors associated with outcome of second twin during labour.
METHODS: The study was a retrospective cohort study in a single tertiary centre in Malaysia from 2014 until 2018 involving all twin pregnancies delivered at or more than 24 weeks of gestation.
RESULTS: Total of 409 twin pregnancies were included. Dichorionic twin comprises of 54.5 % (n=223) and 45.5 % (n=186) are monochorionic. Women with dichorionic pregnancies are significantly older (p<0.001), have more pre-existing medical disorders (p=0.011) and fetal structural anomalies (p=0.009). Monochorionic pregnancies are significantly more amongst Malay (p=0.01) and conceived spontaneously (p<0.001). There are significantly more fetuses both in cephalic presentation (p=0.026), birthweight discrepancy more than 20 % (p=0.038) and shorter mean inter-twin delivery duration (p=0.048) in monochorionic pregnancies. Second twin delivered with Apgar score <7 is significantly more in dichorionic pregnancies (p=0.006). The second twin is associated with lower birthweight, small for gestational age and arterial cord pH<7.25. Within the group of women who delivered both fetuses vaginally, there was significantly more second twins with intertwin delivery duration less than 30 min who were delivered vaginally without instrumentation (p=0.018). There was significantly more second twin with intertwin delivery duration of 30 min and more with arterial cord pH<7.25 (p=0.045). Those who delivered spontaneously had inter-twin delivery duration within 15-29 min. The outcome of second twin is not influenced by type of twin, gestational age at delivery, inter-twin delivery duration, mode of delivery and presentation at birth.
CONCLUSIONS: The neonatal outcome for the second twin at birth is not influenced by type of twin, gestational age at delivery, inter-twin delivery duration, mode of delivery and presentation at birth in a cohort managed with non-active management of the second twin in Malaysia.
Functional recovery following human spinal cord injury (SCI) remains frustratingly limited and the majority of patients are left with severe impairments. While rehabilitative training has been shown to improve clinical outcome following SCI and has a major effect on patients' quality of life, the neuronal mechanisms underpinning neurological and functional recovery are not well understood.

Until recently, degenerative changes in components of the CNS remote to a SCI were thought to occur slowly (over years) and correlate with the degree of disability. Using longitudinal MRI protocols we have shown that these structural changes in fact occur early and progress both at the cord and brain level according to a specific spatial and temporal pattern (Freund et al 2013). It is thought that these trauma-induced structural changes progress retrogradely along central motor nerve fibres of the myelinated corticospinal tract (CST) and this is accompanied over time by shrinkage of corticospinal projecting neuronal bodies. Crucially, patients with less atrophy throughout the CST were those with better clinical recovery at twelve months. Despite this significant recovery advantage in some patients, all participants showed irreversible tissue loss, potentially hindering further recovery. Using the neuroimaging biomarkers established in the previous study cited above, we now aim to assess whether specific and intensive motor learning through tasks for the upper and lower limb might slow or reverse the atrophy seen in the sensorimotor system.
BACKGROUND: Low back pain and neck pain are primary causes of disability, with low back pain being a frequent reason for medical consultations. After conservative and pharmacological treatments, spinal injections are considered the next option. Despite multiple guidelines, spinal blocks remain controversial in terms of indication, technique, and operator, leading to considerable interinstitutional variability. The absence of regional studies in Latin America on how spinal surgeons handle spinal injections prompts the objectives of this study: to evaluate spinal surgeons' knowledge and experience, analyze techniques, and identify barriers and challenges in implementing spinal injections, including resource limitations, technology access, and training.
METHODS: A cross-sectional survey was performed using a questionnaire specifically designed by the authors.
RESULTS: Two hundred sixty spinal surgeons from Latin America participated and answered a 17-question questionnaire; 75% performed their own spinal blocks and they are willing to keep on learning new techniques on the field. The most frequent block, was the lumbar facet injection (80%). And the great majority (76%) used fluoroscopy in their practice.
CONCLUSIONS: The study addresses a critical gap in the literature by focusing on spinal interventions in Latin America, where there is a notable lack of regional studies. The majority of the surgeons enrolled perform their own spinal injections, and they are interested in keep on learning. The findings not only contribute to the global discourse on spinal care but also offer a basis for the development of region-specific guidelines and educational initiatives.
Given the increased risk of burnout among secondary school teachers, effective interventions are needed. Physical activity may play a big role in preventing and/or reducing burnout. Therefore the purpose of this research is to investigate the effect of physical activity on the risk of burnout in secondary school teachers. The participants in the intervention group will be asked to perform a specific physical activity program (including running and/or cycling at a moderate or vigorous intensity) for 6 weeks. The control group will be asked to keep their lifestyle as it was prior to the study. To assess the effect of this activity program, the participants will have to fill in a questionnaire at three time points. Lastly, the participants have to fill in an activity diary every day, enabling to assess intervention adherence.
Helicobacter cinaedi is known to cause invasive infections in immunocompromised adults. Here we report the first case of H. cinaedi bacteremia in a child with nephrotic syndrome. The patient presented with a mild transient febrile illness that resolved spontaneously. We discuss the diagnostic challenges associated with this case and the microbiologic approach, including genomic analysis. Furthermore, we review the current case together with all previous pediatric cases (n = 6). Notably, all cases involved neonates or otherwise immunocompromised individuals and were characterized by severe disease with complicated infections (eg, meningitis, cholangitis and arthritis). H. cinaedi bacteremia in children is associated with a wide spectrum of clinical presentations ranging from mild to life-threatening conditions. This bacterium may be difficult to diagnose and require specialized methods.
Participants who will be randomized randomized to receive placebo in Stage 1 and will be classified as non-responders (responders" if mCGI-S score is ≤ 3 at Day 43 and NPI-C-3 score has decreased by ≥ 25% from baseline. Participants who will not meet these criteria will be considered "non-responders) after Week 6 will be re-randomized to receive AVP-786 in Stage 2 using the same dose escalation schedule used in Stage 1 i.e., AVP-786-28/4.9 capsule, along with AVP-786 matching placebo capsule, orally, QD during Week 7 followed by AVP-786-28/4.9 capsule, orally, BID during Week 8, and AVP-786-42.63/4.9 capsules, orally, BID, during Weeks 9 to 12 of the Stage 2 treatment period.
OBJECTIVE: To treat the fetus presenting with in utero compromise due to a large vein of Galen malformation (VOGM) using glue embolization.
METHODS: The fetus that was referred for termination of pregnancy at 30 weeks of gestation due to severe cardiomegaly, mild pericardial effusion and large VOGM was evaluated using ultrasound. There was reversed end diastolic flow in the umbilical artery Doppler indicating imminent fetal demise in the premature fetus weighing <1200 g. Considering the request of parents, a treatment similar to recently reported cases of VOGM embolization in utero was attempted as an emergency procedure to salvage the baby. Due to unavailability of coils, financial constraints and urgent need for intervention, n-butyl cyanoacrylate glue with lipiodol was used to embolize the venous outflow of VOGM outflow under ultrasonographic guidance.
RESULTS: There was immediate correction of the umbilical artery Doppler waveform with the establishment of a normal flow pattern. The cardiomegaly resolved over 3 weeks and fetal MRI done 2 weeks later showed normal brain architecture with no evidence of hemorrhage or infarction. Pregnancy was continued for 4 weeks after the procedure and terminated at 36 weeks. A female baby weighing 1900 g was delivered by Cesarean section with an Apgar of 8/10. Though initially the baby did well, with mild ventriculomegaly reported on postnatal day 5, she eventually presented at 3 months of age with cardiac failure. As the MRI showed encephalomalacia, due to uncertainty of neurological outcome, further treatment was not pursued by the parents and the baby died a few days later.
CONCLUSION: To our knowledge, this is the first report on the use of glue to treat VOGM prenatally. Though technically successful in correcting the in utero compromise, the baby eventually expired. Cases of in utero embolization using coils and glue have shown success in reversing prenatal pathology and improving survival. However, long-term outcomes including neurological status are yet to be reported.
A turbine-boosted ultraviolet-radiation sterilizing fluid processor includes a quartz sleeve installed inside a tube unit, an ultraviolet-radiation lamp, a fluid inlet tube and a fluid outlet tube arranged at the upper and lower end of the tube-unit being respectively. A diversion mechanism is disposed under the fluid inlet tube. The diversion mechanism is composed of a plurality of diversion channels arranged in a ring unit. The total area of the fluid outlet hole of the diversion channel is smaller than the cross-sectional area of the passage of said tube unit so as to form a fluid-pressurizing chamber on top of the tube unit. Thus a whirlpool spinning at a high speed is created so that the fluid is blended properly. The fluid spinning at high speed also flushes the wall of the quartz sleeve thus increases the sterilizing effects and reduces the frequency for maintenance.
The invention relates to a medicament for treating hyperosteogeny and lumbar intervertebral disc protrusion, which belongs to the technical field of traditional Chinese medicines. The medicament is mainly prepared from the following raw materials according to the parts by weight: 5-10 of saposhnikovia divaricata, 5-10 of notopterygium root, 5-10 of heracleum hemsleyanum michaux, 5-10 of Clematis chinensis, 5-10 of eucommia bark, 5-10 of angelica, 10-20 of radix astragali and 10-15 of futokadsura stem. The medicament can be prepared into various commonly used oral taking dosage forms according to a conventional preparation method of the traditional Chinese medicine. The medicament has the functions of expelling wind, removing heat, spasmolysis, dissolving stasis, stopping pain, dredging orifices, nourishing livers and kidneys, strengthening physique, enriching blood and promoting blood circulation and has quick effect and high curative ratio of treating the hyperosteogeny and the lumbar intervertebral disc protrusion. Generally, 1-3 courses of treatment are needed, and each course lasts for 10 days. The excellent rate of the medicament is 70 percent, and the total effective rate is 96 percent.
NEW MATERIAL:The compound of formula I (R is H or methyl; R<1> is pyridyl, furyl or thienyl; R<2> is lower alkyl, F-substituted lower alkyl or cyclopropyl). EXAMPLE:N-cyclopropyl-3-(2-thienyl)acrylamide. USE:A central muscle relaxant. It has excellent muscle relaxation action and rigidity remission action and is useful as a therapeutic agent for myospasmus dolorosa accompanying to the locomotive disease such as lumbago, dorsalgia and herniated disk and as a therapeutic agent for spasmodic paralysis such as cerebrovascular disorder. PREPARATION:The compound of formula I can be produced by reacting an alkenoic acid of formula II with a halogenation agent (e.g. thionyl chloride) and reacting the resultant acid halide of formula III (X is halogen) with an amine of formula R<2>-NH2.
A novel growth factor (BTC-CG) was purified from the conditioned medium of pancreatic beta tumor cells initially derived from transgenic mice (RIPl-Tag2). The purification scheme included BioRex 70 chromatography, phenyl-Sepharose chromatography, TSL-GEL heparin FPLC and C4 reverse phase HPLC. The peptide also stimulated proliferation of bovine smooth muscle cells. It was not inactivated by boiling, by 10 mM dithiothreitol or by exposure to IM acetic acid. Biological activity of BTC-GF was recovered from a single band of protein which had a molecular weight of 2,000 on SDS-PAGE. The Partial N-terminal amino acid sequence of this protein was determined with an ABI 470A protein sequencer as: Asp-Gly-[X]-Thr-[X]-Arg-Thr-Pro-Glu-[X]-Asn-Gly.
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is associated with disease manifestations in organs other than the gastrointestinal tract. In this study, we aimed to estimate the odds of obstructive lung disease (OLD) before IBD onset and the risk of OLD after IBD onset.
METHODS: In a nationwide population-based Danish cohort study from 1999 to 2018, individuals with IBD and OLD were identified using the Danish registries. Between 2003 and 2013, 24,238 individuals with IBD were identified and matched 1:10 with non-IBD individuals. Logistic regression was used to estimate the prevalence odds ratio for OLD before IBD onset. Time-to-event analysis was performed to explore the risk of OLD after IBD onset. In a sensitivity analysis, the time-to-event analysis was repeated using the composite outcome OLD and the separate outcomes, chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis.
RESULTS: Individuals with IBD were 60% more likely to have OLD before onset (adjusted odds ratio: 1.60, 95% confidence interval [CI]: 1.53-1.67). Furthermore, their risk of OLD was more than 40% higher after IBD diagnosis (adjusted hazard ratio [aHR]: 1.43, 95% CI: 1.37-1.49). The sensitivity analysis increased the risk to 60% (aHR: 1.63, 95% CI: 1.53-1.73). Similar results were found for COPD and asthma separately, whereas the risk of bronchiectasis increased more than 2-fold (aHR: 2.44, 95% CI: 1.91-3.11).
CONCLUSION: The odds of OLD before- and the risk following an IBD diagnosis were increased. We encourage physicians to be vigilant of pulmonary symptoms in persons with IBD and gastrointestinal symptoms in individuals with OLD.
Patients will receive the best medical treatment according to local clinical research standards, including antiplatelet agents, anticoagulants, thrombolysis, etc., excluding any endovascular treatment. In the event of disease progression defined as neurological deterioration leading to an increase in NIHSS ≥4 points and excluding non-stroke factors within 24 hours, remedial endovascular treatment may be taken, including but not limited to stent retriever thrombectomy, aspiration thrombectomy, intra-arterial thrombolysis, balloon angioplasty, stent implantation, etc.
The present invention relates to a Chinese traditional medicine preparation for treating male infertility, which is prepared from 16 pure traditional Chinese medicines including red ginseng, hairy deer-horn, largehead atractylodes rhizome, tuckahoe, cornel, yam, barbary wolfberry fruit and the like. All the traditional Chinese medicines are processed by the modern high-tech superfine technique. The fineness of the superfine powder is 9000 meshes, and the superfine powder is strictly sterilized and capsuled. Each capsule contains 0.35 gram (350 milligrams) of the superfine powder, and the capsule is taken orally. The Chinese traditional medicine preparation for treating male infertility is mainly used for treating sterility caused by male aspermia or the low survival rate of the sperm, and has the efficiency of benefiting qi, replenishing essence, nourishing kidney, strengthening yang, nourishing kidney yin, warming and nourishing kidney yang, clearing heat, dissolving dampness and warming the vital gate. The present invention has the characteristics of short treating period, high cure rate, no obvious toxic or side effect and obvious clinic treating effect, and the cure rate is above 95%.
Initiation of therapy requires consideration of recent diuretic therapy and the possibility of severe salt/volume depletion. In patients with either normal or low blood pressure, who have been vigorously treated with diuretics and who may be hyponatremic and/or hypovolemic, a starting dose of 6.25 or 12.5 mg t.i.d. may minimize the magnitude or duration of the hypotensive effect (see WARNINGS: Hypotension); for these patients, titration to the usual daily dosage can then occur within the next several days.

For most patients the usual initial daily dosage is 25 mg t.i.d. After a dose of 50 mg t.i.d. is reached, further increases in dosage should be delayed, where possible, for at least two weeks to determine if a satisfactory response occurs. Most patients studied have had a satisfactory clinical improvement at 50 or 100 mg t.i.d. A maximum daily dose of 450 mg of captopril tablets should not be exceeded.

Captopril tablets should generally be used in conjunction with a diuretic and digitalis. Captopril tablets therapy must be initiated under very close medical supervision.
Motor Neurone Disease (MND) is a chronic progressive neurological condition where people experience weakness of muscles leading to pain and restriction of movement as well as problems with swallowing, breathing and communication.

As people become increasingly immobile, they become restricted in their ability to perform activities of daily living, access the outdoors, participate in preferred occupational roles or engage in leisure activities. Consequently, there is a deterioration in their ability to experience well being and have quality of life. There is also a significant carer burden as the carer spends long hours in the day looking after the person. The average disease trajectory lasts between 3-5 years, followed by death. More recently, the use of Virtual Reality (VR) technology is being recognised in the field of health. This technology uses the interactions between an individual and a computer generated environment to stimulate different sensory modalities such as visual and auditory. The technology can be accessed commonly using head mounted goggles or head sets. The entertaining or stimulating effect of VR is useful in redirecting the person's attention away from the distressing experiences, such as pain and anxiety. The purpose of this study is to establish if VR is useful for people with MND and if it helps improve their well being.
Blood stasis and blood heat are two pathogens in the theory system of Chinese Medicine, which can cause many diseases independently. But in internal intractable diseases, such as viral hepatitis, stroke, and epidemic hemorrhagic fever, blood stasis and blood heat always accompany with each other. So the hypothesis is raised that blood stasis with heat (YURE) is a compound pathogen and key pathogenesis in internal intractable diseases. This study was aimed to verify the role that the compound pathogen played in hemorrhagic stroke and to observe the progress of the key pathogenesis. A randomized and controlled trial would be conducted in five hospitals, where 300 hospitalized patients with hemorrhagic stroke in the acute phase would receive different intervention with basic modern medicine treatment or Chinese herbs formula combined with the former. The Chinese herbs formula, which was designed under the guidance of the theory system of Chinese Medicine, was supposed to cool blood heat and dissolve blood stasis. Clinical efficacy and safety would be evaluated after the 21-days intervention.