anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A 58-year-old man was admitted with a typical presentation of acute left heart failure. However, the patient showed a partial response to the anti-heart failure therapy. Following admission, a continuous fever was monitored, and a CT scan revealed that multiple opacities on bilateral lungs had progressed. Bronchoscopy was performed, and Coxiella burnetii was detected by Metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage (BALF), and transbronchial lung biopsy showed organizing pneumonia. Considering that the patient had a history of rabbit breeding and delivery, with some newborn rabbits dying before he became ill, organizing pneumonia secondary to Q fever pneumonia was diagnosed. Anti-Q fever treatment was initiated and the patient's temperature returned to normal. Glucocorticoid was administered after adequate treatment for Q fever. The patient's symptom of dyspnea relieved soon and opacities on CT scan were absorbed remarkably. The final diagnosis was organizing pneumonia secondary to Q fever pneumonia accompanied with left heart failure.
Oxycodone Hydrochloride Oral Solution may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g. phenothiazines or general anesthetics) [see Drug Interactions ( 7)]. Monitor these patients for signs of hypotension after initiating or titrating the dosage of Oxycodone Hydrochloride Oral Solution. In patients with circulatory shock, Oxycodone Hydrochloride Oral Solution may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of Oxycodone Hydrochloride Oral Solution in patients with circulatory shock.
BACKGROUND: The prognostic significance of the systemic inflammatory response index (SIRI) in patients with cancer receiving programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) has been widely investigated; however, the results have been conflicting. As such, the present meta-analysis aimed to analyze the precise significance of the SIRI in predicting prognosis in patients with cancer undergoing ICI therapy.
METHODS: A comprehensive literature search of the Web of Science, PubMed, Embase, and Cochrane Library databases for relevant studies, published from inception to April 25, 2024, was performed. The SIRI was analyzed for its prognostic utility in patients undergoing ICI therapy by calculating combined hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).
RESULTS: Six studies comprising 1133 patients were included in the analysis. Pooled data revealed that a higher SIRI was significantly associated with poor overall survival (OS) (HR 1.96 [95% CI 1.55-2.47]; p < 0.001) and progression-free survival (PFS) (HR 1.41 [95% CI 1.19-1.67]; p < 0.001) for patients who underwent PD-1/PD-L1 ICI treatment. Subgroup analysis revealed that SIRI was markedly associated with dismal OS and PFS, independent of sample size, cut-off value, and survival analysis (p < 0.05). The findings were verified to be robust against publication bias and sensitivity analyses.
CONCLUSION: In summary, an elevated SIRI was significantly associated with OS and PFS in patients with cancer undergoing PD-1/PD-L1 ICI treatment. SIRI may a candidate indicator for predicting the prognosis of patients undergoing ICI therapy.
Achieving favorable seizure outcomes is challenging in patients with seizures resulting from hypothalamic hamartoma. Although minimally invasive and non-invasive surgical procedures are used to treat this population, these procedures have limitations. Therefore, we analyzed the outcomes of patients with hypothalamic hamartoma following direct resection. We included 159 patients with hypothalamic hamartoma who underwent direct resection using the transcallosal interforniceal approach between 2011 and 2018. The relationships between clinical parameters and seizure outcomes were analyzed. In total, 55.3% achieved gross total resection and 25.2% underwent near-total resection. Of all patients, 79.2% were overall seizure-free at one year, but this number dropped to 77.0% at more than five years. Moreover, 88.4% (129/146) reached gelastic seizure (GS)-free status at one year and this number increased to 89.0% (97/109) at more than five years. Seventy-one patients took antiseizure medication (ASM) long-term, 68 took it for one year, and 11 took it for one-half year. The duration of ASM consumption (p < 0.001) and extent of hypothalamic hamartoma resection (p = 0.016) were significant independent predictors of long-term overall seizure-free survival, while the duration of ASM consumption (p = 0.011) and extent of hypothalamic hamartoma resection (p = 0.026) were significant independent predictors of long-term GS-free survival. Most patients' behavior, school performance, and intelligence were not affected after surgery. Direct resection is effective and safe strategy for patients with hypothalamic hamartomas. Hypothalamic hamartomas should be removed as completely as possible, and patients should take ASM long-term following surgery to reach long-term overall seizure-free or GS-free status.
The study will assess the efficacy, safety, and tolerability of add-on therapy with ponesimod 20 mg vs placebo in adult participants with active relapsing multiple sclerosis (RMS) who are treated with dimethyl fumarate (DMF). Approximately 600 participants who have been receiving DMF for at least 6 months will be randomized in a 1:1 ratio to ponesimod 20 mg or placebo. The study consists of the following study periods: Pre-randomization period; Treatment period; Post-treatment observation period. The study includes one ponesimod treatment arm at the maintenance dose of 20 mg o.d. corresponding to the optimal dose when used as monotherapy based on the Phase 2 dose-finding trial and its ongoing extension. The study includes a placebo comparator arm, but all patients will remain on DMF background therapy throughout the study. Moreover, participants who experience a confirmed relapse or an event of 24-week confirmed disability accumulation (DMF) while on study drug will have the option to switch to an alternative treatment. The treatment period has a variable duration from a minimum of 60 weeks (for the last subject randomized) to a maximum of 156 weeks for the first subjects randomized in the trial and includes a gradual up-titration of ponesimod from a 2 mg starting dose to a 20 mg maintenance dose over a period of 14 days. The total duration of the study will be approximately up to 167 weeks.
The invention relates to the field of biomedicine, and particularly relates to bifidobacterium adolescentis DH162 and a fermentation product, application and a microecological preparation thereof. The preservation number of the bifidobacterium adolescentis is CGMCC No. 13233. The bifidobacterium adolescentis DH162 microecological preparation can achieve the anti-aging effect through different action mechanisms, and the specific mechanism comprises the anti-aging effect which can be achieved through the action mechanisms of enhancing the body antioxidant capacity, improving the immunity, regulating the intestinal flora, improving the neurotransmitter and the like. And the traditional Chinese medicine composition has obvious curative effect, takes effect quickly and has good effect without adverse reaction and side effect compared with other treatment modes. Can be used as medicine, health product, food, veterinary drug and feed additive, and has great social significance.
The invention provides a lactobacillus helveticus microcapsule as well as the preparation and application thereof, pertaining to the embedding technology of lactobacillus helveticus and aiming at microencapsulating the lactobacillus helveticus so as to solve the problems of low embedding efficiency and embedding yield in single-layer or double-layer embedment. The technical proposal adopted by the invention is that isolated soy protein, microporous starch and sodium alginate are respectively taken as the first, the second and the third layers of wall materials for microencapsulation; the three-layer embedment is carried out to the lactobacillus helveticus for the first time, wherein, in the process of preparing bacterial suspension, an orthogonal optimization protective agent is adopted to improve the livability after freeze drying. The microcapsule of the invention has strong heat resistance and acid resistance, solves the inactivation problem caused by gastric acid, digestive enzyme and antibiotic, etc. to active bacillus, is capable of releasing when reaching large intestine, and balances intestinal flora. The reusability of fermented milk is good. The lactobacillus helveticus used by the invention enriches the variety of probiotic bacteria microcapsule and is a good dietary supplement.
The AB subject group will receive OnabotulinumtoxinA in the first treatment and saline placebo in the second.Both groups will then receive OnabotulinumtoxinA in the last two treatments. There will be one treatment at the beginning of each 12 week block, meaning 4 treatments over the 48 week study period total. Progress check-ups will occur every 6 weeks during the study. Randomization will be via selection of sealed envelope.
The present invention discloses a sanhuang dripping pill which is an improved dosage form of a sanhuang preparation. The present invention uses the extract of rhubarb, scutellaria root extractum and berberine hydrochloride as effective components, and uses polyethylene glycol as substrate. The effective components are pulverized, mixed and added in the melting substrate, and are uniformly stirred. Dimethyl silicon oil is dropped under a homothermal condition of 80 to 85 DEG C, and the effective components are condensed into dripping pills. The silicon oil is removed, and the effective components are made after dried. Because a solid dispersion method is used, a gap is small after the dripping pill substrate and a pharmaceutical granulate are combined. The contact area of the pharmaceutical granulate with the air is reduced, so the effective components are safe from influence of the air, and the stability is not reduced. The dripping pill has the advantages of fast dissolving speed, small pharmaceutical granulate and high bioavailability of active components. The dripping pill of the present invention is also easily dissolved in water to form solution.
The purpose of this study is to evaluate the blood flow to the heart during stress and assess changes in blood flow after psychological treatment in participants with coronary artery disease. This is a randomized controlled study. The aims of the study are to assess the effects of heart rate variability (HRV) biofeedback (versus usual care) on global and regional myocardial blood flow (MBF), peripheral vascular function, and autonomic changes during mental stress.

All participants will undergo myocardial flow/perfusion imaging with positron emission tomography (PET) imaging at rest and after a standardized arithmetic mental stress test. Participants will then undergo repeat testing after 6 weeks. At 12 weeks, participants will also undergo a limited examination without myocardial perfusion imaging. The intervention group will receive biofeedback after enrollment, and the wait-list control group will receive the intervention between week 6 and week 12 study visits (without imaging).
The present invention discloses a medicine for treating leukoderma and a preparing method thereof. A plurality of medicines for treating leukoderma are used at present, but most of the medicines have the defects of long treating time, poor therapeutic effect, slow effect, etc. According to the condition of the focus of leukoderma, the medicine of the present invention is applied and eaten. The present invention is divided into a medicine for external use and a medicine for oral administration, wherein the medicine for external use is formed by adding several kinds of Chinese medicine ingredients on the basis of the ingredients, such as psoralea fruit, blister beetles, ginger, calomelas, litharge, etc.; the medicine for oral administration is formed by adding several kinds of Chinese medicine ingredients on the basis of the ingredients, such as flaxseeds, raw liquorice roots, mint, raw angelica, etc. Through clinical verification, the medicine for external use and the medicine for oral administration have quick effect. Generally, leukoderma can be cured in 2 to 5 months, and the curing rate is from 90% to 95%. The present invention is an ideal effective medicine for treating leukoderma.
While the use of pessary in this scenario has not been previously assessed, it is reasonable to infer, from the data for use of pessary to prevent preterm birth, and the data regarding the efficacy of cervical cerclage in reducing bleeding and preterm birth in patients with placenta previa to this clinical conundrum. If cerclage improves pregnancy outcomes in patients with placenta previa, the use of a vaginal pessary should be a less-invasive but similarly efficacious alternative to maintain cervical length. The purpose of this study is to compare two treatment options reasonably used in clinical practice. Use of cervical pessary is not expected to increase antenatal costs beyond the minimal cost of the pessary. Additionally, given the results of the available clinical trials on cerclage maintaining cervical length and decreasing bleeding, this procedure has the potential to decrease the cost of both antepartum admissions for bleeding and neonatal care.

A substantial number of women with placenta previa will not hemorrhage until they reach the third trimester, thus, by allowing for enrollment and pessary placement as late as 32w0d, the intervention may be applied to the broadest "at risk" population. As previously mentioned literature on the use of cerclage in patients with placenta previa and short cervix are limited by a reduced number of eligible subjects and concern over safety issues has not been assuaged by these small studies. As pessary placement appears to carry little if any risk based on a number of published studies, eligibility can be expanded to any cervical length.
The disclosure herein teaches a method for preserving cosmetics, including hair dye, that are prone to oxidation. The method uses an apparatus for automatically sealing and resealing, so as to prevent oxidation immediately and thereafter the cosmetic products are dispensed, or breached, from their manufacturer packaging. In the proposed apparatus, this is done by producing negative pressure inside a chamber while the cosmetic product is inside an unsealed container within the chamber. The vacuum is produced by a pump connected to an on-off valve, which is directly or indirectly actuated under micro-controlled processes. The one-way flow of air from the chamber to the apparatus? exterior produces negative pressure inside the chamber. Packaging can be sealed by outside influence or sealed by the pressure difference between the outside environment and the inside of the packaging upon the rapid repressurizing of the chamber. These processes prevent oxidation or degradation of the cosmetic product therein. Data related to the properties of the sealed cosmetic product or products is captured and stored in the device in transient or permanent memory and aggregated, analyzed and retrieved at will by a user. Communication and interaction between user and machine can occur physically (using a switch and a luminous indicator), or wirelessly with a mobile device. The resulting product, created to unique specifications from the original manufacturer packaging, can now be stored for an extended period of time without significant degradation of the efficacy.
A method of beamforming datasets from a tomographic detection system. The system comprises scintillation detectors that are arranged in D detector pairs, D≥1, wherein the detectors are adapted to count radiation hits. According to the method in one aspect, a tomographic dataset is received for each detector pair coordinates (θd, pd) of a detector pair d of the D detector pairs, so as to obtain a plurality of tomographic datasets. Each of said datasets is associated with respective detector pair coordinates (θd, pd). Then, for each point y of interest, the received datasets are coherently combined by weighting the datasets according to respective beamforming weights d(y)=ω(θd, pd; y), based on said respective detector pair coordinates (θd, pd) and coordinates of said each point y of interest. This way, a signal focusing on said each point y is obtained. Related tomographic detection systems and computer program products may be also presented.
Graves' disease is an autoimmune disease that affects the thyroid gland\[1\] and it's the most common cause of hyperthyroidism. \[2\] Treatment of Graves' disease includes antithyroid drugs ; radioiodine ; and thyroidectomy . patients with Graves' hyperthyroidism can be treated with any of these treatment options. There is a wide geographic variation in the choice of therapy.\[3\] Medical treatment with antithyroid drugs is often accepted as first-choice modality in Europe, followed by radioiodine in case of recurrence. Although surgery offers the advantage of quick control and low morbidity in experienced hands, it is infrequently recommended as initial treatment. Therapy with radioiodine is the most common treatment in the United States, while antithyroid drugs and/or thyroidectomy are used more often in Europe, Japan, and most of the rest of the world.recent literature shows that the relapse rate was the highest among patients who received antithyroid drugs (40%) as compared to those who received radioiodine (21%) or Surgery (5). \[4\] Two different surgical techniques are used for the treatment of Graves' hyperthyroidism: a total thyroidectomy (TT) in which the entire gland is removed and a subtotal thyroidectomy (STT) , in which most of the gland is removed leaving a small unilateral or bilateral remnant in situ about 4-5 grams. Although thyroidectomy has been broadly considered as a viable alternative theapy for patients with Graves' disease , the resection extent and remnant size of thyroid gland remains controversial.\[6\] Although total thyroidectomy has a lower recurrence rate it has raised a concern that a more radical operation would increase the complications.\[7\] we intend to perform this analysis based on the published literatures of randomized controlled trials to evaluate the specific risks of thyroid surgery including recurrent hyperthyroididm , post-operative bleeding , recurrent laryngeal nerve injury , hypoparathyroidism and opthalmopathy progression.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic fouling neither finger nor the like, easily applicable, capable of suitably absorbing sebum and useful for improving and preventing greasiness of the sebum and messy makeup by including a specific amount of a specific oil absorbent powder. SOLUTION: This cosmetic is obtained by including 10-60 wt.% (A) oil absorbent powder having >=1 ml/g squalane absorption. Especially, the component A is preferably included 15-40 wt.%. This cosmetic preferably includes additionally (B) a hydrous gel comprising (i) water-soluble polymer and (ii) a crosslinking agent. The component i is preferably formulated 1-30 wt.% especially 2-25 wt.% per whole composition. The component ii is preferably compounded 0.01-5 equivalent especially 0.1-2 equivalent per closslinkable position of the component i. The component A is preferably a porous powder having 0.005-30 μm mean particle diameter and preferably >=90 wt.% component A has 0.005-30 μm particle diameter.
The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and a preparation method thereof. The composition is characterized by being prepared from the following raw materials in parts by weight: 20 to 30 parts of the root of red-rooted salvia, 15 to 25 parts of the root of kudzu vine, 10 to 15 parts of pseudo-ginseng, 8 to 12 parts of rhizoma gastrodiae, 10 to 20 parts of cortex cinnamomi, 5 to 10 parts of safflower carthamus, 6 to 12 parts of centipedes and 4 to 8 parts of long-noded pit vipers. The preparation method comprises the following steps: performing aqueous extraction on the root of red-rooted salvia, the root of kudzu vine, the pseudo-ginseng, the rhizoma gastrodiae, the cortex cinnamomi and the safflower carthamus which are taken as the raw materials; drying the centipedes and the long-noded pit vipers and then smashing; performing alcohol extraction on the smashed centipedes and long-noded pit vipers; drying and smashing extracts; and then mixing the extracts. Animal and human experiments indicate that the composition has a good effect for treating the cervical spondylosis and is obvious in coordination and treatment effects. The composition is milder and more lasting in actions and has a small side effect by adopting a scientific formula and a proper extraction process which are combined with the physicochemical properties and the pharmacologic actions of the traditional Chinese medicines. The composition is capable of activating the channels and collaterals and promoting blood circulation, and has the good health-care and treatment effects for treating the cervical spondylosis.
NOV-002 is given by IV bolus on lead-in day -1 at cycle 1, and on day 1 at subsequent cycles, followed by Carboplatin AUC 5. NOV-002 is then continued via daily SC injection, with 28 day cycles.
Pulse oximetry is widely used to non-invasively estimate the oxygen saturation of haemoglobin in arterial blood (SpO2). It is used widely throughout healthcare and was used extensively during the Covid-19 pandemic to detect and treat hypoxic patients. Research has suggested that pulse oximetry is less accurate in patients with darker skin. This led the US Food and Drug Administration agency (FDA) to issue a safety statement warning that pulse oximeters may be inaccurate when patients have pigmented skin. Evidence suggests that the oxygen saturation of arterial blood (SaO2) may be being overestimated by measuring SpO2 in those with pigmented skin. The degree of overestimation increases as SaO2 decreases especially when SpO2 reads below 80%. We review how pulse oximetry works and consider the implications for a patient's health when interpreting SpO2 in individuals with pigmented skin.