anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses hard candies capable of treating dental ulcer, and relates to the technical field of candies. The hard candies capable of treating dental ulcer are prepared from the following raw materials: 30-40 parts of condensed milk, 50-60 parts of white granulated sugar, 15-25 parts of glucose syrup, 2-4 parts of table salt, 1-3 parts of edible essences, 4-6 parts of food additives, 10-20 parts of maltol, 20-30 parts of xylitol, 2-4 parts of mineral additives, 1-3 parts of red sage roots, 2-4 parts of pseudo ginseng roots, 1-3 parts of rhizomes of Sichuan lovage, 1-3 parts of safflowers, 6-8 parts of peach kernels, 2-4 parts of lycopus herbs, 2-4 parts of Chinese angelica roots, 3-5 parts of roots of tuber fleece-flower, 4-6 parts of giant hyssop leaves, 2-4 parts of herbs of fortune eupatorium and 3-5 parts of dandelion herbs. The invention has the following beneficial effects: the hard candies are rationally formulated, and the preparation method is simple. The prepared hard candies are mellow in flavor as well as delicious and sweet in taste; moreover, the hard candies have the medicinal effects of treating dental ulcers. The hard candies are leisure foods, and have the effects of treating diseases, so that the hard candies achieve two things at one stroke. The hard candies are suitable for dental-ulcer patients in long-term consumption.
AIM: Optimising preconception health increases the likelihood of conception, positively influences short- and long-term pregnancy outcomes and reduces intergenerational chronic disease risk. Our aim was to synthesise study characteristics and maternal outcomes of digital or blended (combining face to face and digital modalities) interventions in the preconception period.
METHODS: We searched six databases (PubMed, Cochrane, Embase, Web of Science, CINHAL and PsycINFO) from 1990 to November 2022 according to the PRISMA guidelines for randomised control trials, quasi-experimental trials, observation studies with historical control group. Studies were included if they targeted women of childbearing age, older than 18 years, who were not currently pregnant and were between pregnancies or/and actively trying to conceive. Interventions had to be delivered digitally or via digital health in combination with face-to-face delivery and aimed to improve modifiable behaviours, including dietary intake, physical activity, weight and supplementation. Studies that included women diagnosed with type 1 or 2 diabetes were excluded. Risk of bias was assessed using the Academy of Nutrition and Dietetics quality criteria checklist. Study characteristics, intervention characteristics and outcome data were extracted.
RESULTS: Ten studies (total participants n=4,461) were included, consisting of nine randomised control trials and one pre-post cohort study. Seven studies received a low risk of bias and two received a neutral risk of bias. Four were digitally delivered and six were delivered using blended modalities. A wide range of digital delivery modalities were employed, with the most common being email and text messaging. Other digital delivery methods included web-based educational materials, social media, phone applications, online forums and online conversational agents. Studies with longer engagement that utilised blended delivery showed greater weight loss.
CONCLUSION: More effective interventions appear to combine both traditional and digital delivery methods. More research is needed to adequately test effective delivery modalities across a diverse range of digital delivery methods, as high heterogeneity was observed across the small number of included studies.
A method for evaluating sleep disorders in mammals and distributing control information related to the sleep disorders through electronic communication networks. The method includes acquiring analog information related to physiological signals through a mobile device from a mammal user. The mammal user is at a geographic location outside of a sleep laboratory staffed by trained technicians. The mobile device is coupled to a sensing device, which is coupled to monitoring region(s) of the mammal. The method includes converting the analog information into a digital format using a signal processing device and transmitting information related to the physiological signals in the digital format to one or more service computers through an electronic communications network. Each of the service computers is operably coupled to a health information service facility. The method determines if the mammal user has related control information at one of the health information service facilities. The related control information is received through the communication network. The method processes the information related to the physiological signals at one or more of the service computers to provide a report associated with the information related to the physiological signals and the mammal user. The method communicates report information in the report associated with the information related to the physiological signals upon indication of receipt of at least control account information of the mammal user based upon the determining the related account information.
BACKGROUND: Transdiaphragmatic intrapericardial herniation (DIPH) of intra-abdominal organs is a rare but potentially life-threatening phenomenon often requiring urgent repair. There are currently no guidelines on the preferred repair technique in this situation.
METHODS: Retrospective case report with long-term follow-up. We describe a case in which the left liver herniated into the pericardium after coronary artery bypass grafting (CABG) using the right gastroepiploic artery (RGEA).
RESULTS: Urgent laparoscopic reduction of the liver herniation and repair of the large diaphragmatic defect was performed using an expanded polytetrafluoroethylene (ePTFE) mesh in a 50 year old male patient. Hemodynamic instability normalized after the hernia reduction. The postoperative course was uneventful. CT-scan evaluation after 9 and 20 years of follow-up showed perfect integrity of the mesh.
CONCLUSION: A laparoscopic approach for DIPH is feasible in emergency situations provided sufficient hemodynamic stability of the patient. On-lay ePTFE mesh repair is a valid option for such repairs. We illustrate the long-term durability and safety of ePTFE for DIPH repair in what seems to be by far the longest documented follow-up after laparoscopic ePTFE mesh repair for DIPH.
Hyaluronidases (HAases) are enzymes that degrade hyaluronic acid (HA) in the animal kingdom. The HAases-HA system is crucial for HA homeostasis and plays a significant role in biological processes and extracellular matrix (ECM)-related pathophysiological conditions. This study aims to explore the role of inhibiting the HAases-HA system in acute kidney injury (AKI). We selected the potent inhibitor "sHA2.75" to inhibit HAase activity through mixed inhibitory mechanisms. The ischemia-reperfusion mouse model was established using male BALB/c mice (7-9 weeks old), and animals were subjected to subcapsular injection with 50 mg/kg sHA2.75 twice a week to evaluate the effects of sHA2.75 on AKI on day 1, 5 and 14 after ischemia-reperfusion or sham procedure. Blood and tissue samples were collected for immunohistochemistry, biochemical, and quantitative analyses. sHA2.75 significantly reduced blood urea nitrogen (BUN) and serum creatinine levels in AKI mouse models. Expression of kidney injury-related genes such as Kidney injury molecule-1 (KIM-1), Neutrophil Gelatinase-Associated Lipocalin (NGAL), endothelial nitric oxide synthase (eNOS), type I collagen (Col1), type III collagen (Col3), alpha-smooth muscle actin (α-SMA) showed significant downregulation in mouse kidney tissues after sHA2.75 treatment. Moreover, sHA2.75 treatment led to decreased plasma levels of Interleukin-6 (IL-6) proteins and reduced mRNA levels in renal tissues of AKI mice. Inhibitor sHA2.75 administration in the AKI mouse model downregulated kidney injury-related biomarkers and immune-specific genes, thereby alleviating AKI in vivo. These findings suggest the potential use of HAase inhibitors for treating ischemic reperfusion-induced kidney injury.
Oxymorphone hydrochloride tablets should be used with caution in elderly patients [see Clinical Pharmacology (12.3)].

Of the total number of subjects in clinical studies of oxymorphone hydrochloride tablets, 31% were 65 and over, while 7% were 75 and over. No overall differences in effectiveness were observed between these subjects and younger subjects. There were several adverse events that were more frequently observed in subjects 65 and over compared to younger subjects. These adverse events included dizziness, somnolence, confusion, and nausea. In general, dose selection for elderly patients should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration. Titrate the dosage of oxymorphone hydrochloride tablets slowly in geriatric patients and frequently reevaluate the patient for signs of central nervous system and respiratory depression [see Warnings and Precautions (5.7)].

Oxymorphone is known to be substantially excreted by the kidney and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because the elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
The invention discloses herbal tea prepared from mesona chinensis benth, lalang grass rhizome, gardenia jasminoides, pheasant rice, polygonatum odoratum, aralia elata seem, dandelion, reed rhizome, poria cocos and lotus seeds and used for preventing and treating heart fire dryness-heat and a preparation method thereof. The heart is an important viscera in the zang-fu organs and plays the role of governing life activities, so it is called "monarch organ". Different pathological manifestations can occur in cardiac dysfunction. Fire-heat is a yang pathogen, which is responsible for heart and governs blood vessels to store spirit, so exuberant fire can cause blood heat or hemokinesis, and emotional restlessness, dysphoria, delirium, mania or coma due to pathogenic fire disturbing heart. The heart and the small intestine are exterior-interior to each other, and the heart fire moves downward, i.e. it moves downward to the small intestine along the meridians, resulting in yellow and reddish urine, burning pain, etc. Therefore, the herbal tea for preventing and treating the heart fire dryness-heat is prepared by taking the traditional Chinese medicines as the raw materials, and has the characteristics of simplicity, convenience, low cost and effectiveness.
There will be a 14 day period when all participants will receive placebo, followed by 5 mg donepezil, once daily for 14 days then titrated to 10 mg donepezil once daily for 70 days. Participants may then receive open-label donepezil for an additional 24 weeks.
<P>PROBLEM TO BE SOLVED: To provide: novel peptides based on an HIV gag p24 protein-preserved region; antigens isolated or bonded to a carrier containing at least one of the peptides; vaccine compositions containing at least one of the antigens; immunoassay kits; and methods for detecting antibodies induced by human immunodefficiency virus (HIV) or HIV-specific peptides by using the antigens.  <P>SOLUTION: The novel and modified peptides having potency to induce HIV-1-specific immunoresponse without antagonizing to cytotoxic T cell activity are provided to achieve preventive and therapeutic vaccine effective to HIV. The peptides are based on a preserved region of HIV gag p24 protein. Isolated antigens or those in a form binding to a carrier, containing at least one of the peptides are provided. Vaccine compositions containing at least one of the antigens, immunoassay kits and methods for detecting the antibodies induced by HIV or HIV-specific peptides by using the antigens are also provided.  <P>COPYRIGHT: (C)2011,JPO&INPIT
One hundred five subjects will be enrolled and randomized 2:1 to receive either INNO-206 or doxorubicin. INNO-206 at a dosage of 350 mg/m2 (doxorubicin equivalents of 260 mg/m2) will be administered as a 30 minute IVI on Day 1 of each cycle to approximately 70 subjects. Doxorubicin (75 mg/m2) will be administered to approximately 35 subjects on Day 1 of each cycle. An individual cycle of therapy will be defined as a 3-week (21-day) period. Cycles will be repeated every 3 weeks. Multiple cycles may be administered until the subject is withdrawn from therapy or until a maximum of 6 cycles are administered. Overall response rates as well as individual categories of response (CR, PR, SD, and PD) will be determined using RECIST 1.1.\[28\] Time-to-event endpoints, including PFS and OS will be assessed using the Kaplan Meier method.\[30\] Evaluation of 4- and 6-month progression-free survival will also be performed. Toxicity (adverse events) will be recorded using the NCI CTCAE, version 4.0 (published 28 May 2009).
FIORICET with CODEINE contains codeine. Codeine in combination with butalbital, acetaminophen, and caffeine is a Schedule III controlled substance. As FIORICET with CODEINE contains butalbital and codeine, it exposes users to the risks of addiction, abuse, and misuse [see Drug Abuse and Dependence (9)].

Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed FIORICET with CODEINE. Addiction can occur at recommended dosages and if the drug is misused or abused.

Assess each patient’s risk for addiction, abuse, or misuse prior to prescribing FIORICET with CODEINE, and monitor all patients receiving FIORICET with CODEINE for the development of these behaviors and conditions. Risks are increased in patients with a personal or family history of substance abuse (including drug or alcohol abuse or addiction) or mental illness (e.g., major depression). The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as FIORICET with CODEINE but use in such patients necessitates intensive counseling about the risks and proper use of FIORICET with CODEINE along with intensive monitoring for signs of addiction, abuse, and misuse.

Consider prescribing naloxone for the emergency treatment of opioid overdose [see Dosage and Administration (2.2), Warnings and Precautions (5.3)].

Opioids and barbiturates are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing FIORICET with CODEINE. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on the proper disposal of unused drug [see Patient Counseling Information (17)]. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.
The long arm of the Y chromosome (Yq) contains many amplified and palindromic sequences that are prone to self-reorganization during spermatogenesis, and tiny submicroscopic segmental deletions in the proximal Yq are called Y chromosome microdeletions (YCM). A retrospective study was conducted on male infertility patients of Zhuang ethnicity who presented at Reproductive Medical Center of Nanning between January 2015 and May 2023. Seminal fluid was collected for standard examination. YCM were detected by using a combination of multiplex PCR and agarose gel electrophoresis. Preparation of peripheral blood chromosomes and karyotyping of chromosomes was performed. 147 cases (9.22%) of YCM were detected in 1596 male infertility patients of Zhuang ethnicity. Significant difference was found in the detection rate of YCM between the azoospermia group and the oligospermia group (P < 0.001). Of all types of YCM, the highest detection rate was AZFc (n = 83), followed by AZFb + c (n = 28). 264 cases (16.54%) of sex chromosomal aberrations were detected. The most prevalent karyotype was 47, XXY (n = 202). The detection rate of sex chromosomal aberrations in azoospermia group was higher than that in severe oligospermia group and oligospermia group, and the differences were significant (P < 0.001). 28 cases (1.57%) of autosomal aberrations and 105 cases (6.58%) of chromosomal polymorphism were identified. The current research has some limitations due to the lack of normal men as the control group but suggests that YCM and chromosomal aberrations represent key genetic factors influencing spermatogenesis in infertile males of Zhuang ethnicity in Guangxi.
Preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (NICU). While some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. Emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. We hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. This may ultimately represent a therapeutic target to improve the growth of preterm infants in the NICU. This study aims to describe the differences in microbiome which may vary with growth pattern.
Prolonged intense exercise induces acute renal injury; however, the precise mechanism remains unclear. We investigated the effects of neutrophil depletion in male C57BL/6J mice. Male C57BL/6J mice were divided into four groups: sedentary with control antibody; sedentary with antineutrophil antibody; exhaustive exercise with control antibody; and exhaustive exercise with antineutrophil antibody. Antineutrophil (1A8) or control antibody was administered i.p. to the mice before they ran on a treadmill. Plasma levels of creatinine and blood urea nitrogen (BUN) were measured. Renal histology was assessed 24 h after exhaustive exercise, and the concentration of kidney injury molecule (KIM)-1 was measured using an enzyme-linked immunosorbent assay. The expression levels of inflammatory cytokines were measured using qRT-PCR. Furthermore, NADPH oxidase activity and the hydrogen peroxide concentration in the kidney were measured. Immediately after exhaustive exercise, plasma BUN was significantly increased, but creatinine was not. The increase in BUN after exercise was suppressed by 1A8 treatment. The pathological changes manifested as congested and swollen glomeruli and nuclear infiltration after exhaustive exercise. These changes were suppressed by treatment with the 1A8 antibodies. The KIM-1 concentration increased after exhaustive exercise but was reduced by the 1A8 antibodies. Treatment with the 1A8 antibody also decreased exhaustive exercise-induced inflammation and reactive oxygen species levels in the kidney. These results suggest that neutrophils contribute to exercise-induced acute renal injury by regulating inflammation and oxidative stress.
Gene Transfer for Artemis-Deficient Severe Combined Immunodeficiency (ART-SCID) Using a Self-Inactivating Lentiviral Vector (AProArt) to Transduce Autologous CD34 Hematopoietic Cells. The CliniMACS® CD34 Reagent System sorter device will be used to select CD34 cells. Patients will be conditioned with low dose busulfan prior to transplant.
Carcinogenicity studies have not been conducted with pirtobrutinib. 

Pirtobrutinib was not mutagenic in a bacterial mutagenicity (Ames) assay. Pirtobrutinib was aneugenic in in vitro micronucleus assays using human peripheral blood lymphocytes. Pirtobrutinib was not genotoxic in an in vivo rat bone marrow micronucleus assay at doses up to 2000 mg/kg. 

Studies to assess the effects of pirtobrutinib on fertility have not been conducted. In repeat-dose toxicity studies of up to 3-months duration conducted with pirtobrutinib in rats and dogs, no effects on male or female reproductive organs were identified.
The present invention relates to the food production, namely to the producing food product having antimicrobial activity against Helicobacter pylori. The offered food product - dessert contains composition of substances that suppresses gut pathogenic microflora, protects mucous membranes of the gastrointestinal tract against aggressive factors' activity, and does not exceed bounds of regulation of physiological processes. The aforesaid composition of substances is being prepared of quince juice, chokeberry juice concentrate (preferably of quintuple concentration of chokeberry juice) and cranberry juice by adding extract of green tea and vitamin C, sodium benzoate and sugar. Further the received mixture is being heated up, added the suspension of corn starch in the water extract of the apple cake and water extract of sweet flag rootstocks, by stirring of food product it is being lead up to jelly like consistency and cooled. As a result the functional food product (dessert) is received with antimicrobial activity against Helicobacter pylori. In another embodiment of invention at the step of preparing the fruit and berry juice mixture, the suspension of corn starch in the water extract of apple cake is added to the heated up concentrate of chokeberry and, after forming jelly, the quince juice, cranberry juice, extract of green tea, water extract of sweet flag rootstocks, vitamin C, sodium benzoate and sugar is added to the mixture.
Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6 th  and 8 th  and/or the 10 th  and 13 th  weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.