anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Hemiplegic shoulder pain (HSP) is a common complication after stroke. It severely affects the recovery of upper limb motor function. Early shoulder pain in hemiplegic patients is mainly neuropathic caused by central nerve injury or neuroplasticity. Commonly used corticosteroid injections in the shoulder joint can reduce shoulder pain; however, the side effects also include soft tissue degeneration or increased tendon fragility, and the long-term effects remain controversial. Botulinum toxin injections are relatively new and are thought to block the transmission of pain receptors in the shoulder joint cavity and inhibit the production of neuropathogenic substances to reduce neurogenic inflammation. Some studies suggest that the shoulder pain of hemiplegia after stroke is caused by changes in the central system related to shoulder joint pain, and persistent pain may induce the reorganization of the cortical sensory center or motor center. However, there is no conclusive evidence as to whether or not the amelioration of pain by botulinum toxin affects brain function. In previous studies of botulinum toxin versus glucocorticoids (triamcinolone acetonide injection) in the treatment of shoulder pain, there is a lack of observation of differences in changes in brain function. As the content of previous assessments of pain improvement was predominantly subjective, objective quantitative assessment indicators were lacking. Functional near-infrared imaging (fNIRS) can remedy this problem.
METHODS: This study protocol is designed for a double-blind, randomized controlled clinical trial of patients with post-stroke HSP without biceps longus tenosynovitis or acromion bursitis. Seventy-eight patients will be randomly assigned to either the botulinum toxin type A or glucocorticoid group. At baseline, patients in each group will receive shoulder cavity injections of either botulinum toxin or glucocorticoids and will be followed for 1 and 4 weeks. The primary outcome is change in shoulder pain on the visual analog scale (VAS). The secondary outcome is the assessment of changes in oxyhemoglobin levels in the corresponding brain regions by fNIRS imaging, shoulder flexion, external rotation range of motion, upper extremity Fugl-Meyer, and modified Ashworth score.
DISCUSSION: Ultrasound-guided botulinum toxin type A shoulder joint cavity injections may provide evidence of pain improvement in patients with HSP. The results of this trial are also help to analyze the correlation between changes in shoulder pain and changes in cerebral hemodynamics and shoulder joint motor function.
TRIAL REGISTRATION: Chinese clinical Trial Registry, ChiCTR2300070132. Registered 03 April 2023, https://www.chictr.org.cn/showproj.html?proj=193722 .
INTRODUCTION: Alcohol use disorder (AUD) is present in the majority of patients with alcohol-associated liver disease (ALD), which leads to about 50% of cirrhosis-related hospitalizations and over 25% of deaths worldwide. Patients with ALD often present at an advanced stage, like cirrhosis with its complications and alcohol-associated hepatitis (AH), which has high short-term mortality. Current treatments are limited, with the limited benefit of glucocorticoids only in the short-term among patients with AH, highlighting an urgent need for novel therapies.
AREAS COVERED: This review applies the PIRO (Predisposition, Injury, Response, Organ dysfunction) concept to ALD, understanding an ongoing process of liver damage, and opportunities to address and halt the progression. We also highlight the significance of treating AUD to improve long-term outcomes in ALD.
EXPERT OPINION: Personalized therapies targeting specific genetic profiles and multiple pathogenic pathways are crucial in managing ALD. Emerging therapies like gut-liver-brain axis modulators like fecal microbiota transplant and probiotics, interleukin-22, granulocyte-colony stimulating factor (G-CSF) and stem cells, epigenetic regulators of inflammation and regeneration are encouraging with the potential of efficacy in patients with ALD. Liver transplantation (LT) is a definitive therapy for advanced cirrhosis with increasing impetus on early LT select patients with active alcohol use.
Scald instant recover is an all-natural biological preparation, and belongs to medicines. The scald instant recover is a specific medicine developed for scald, and has a magical effect for scald. When the scald instant recover is used for scald, the medicine can quickly act on cuticle tissue of the scald site, activate cuticle cells, quickly repair the scald site, and make the scald site recover rapidly. The time for recovery of the original condition is within 30 minutes. No scars will leave, and recurrence will never happen. The scald instant recover is suitable for the fields of mild scalds, moderate scalds, and severe scalds.
The present invention discloses a traditional Chinese medicine of naodesheng soft capsule novel formulation for treating stroke and a preparation method thereof. A soft capsule preparation with the advantages of high bioavailability, good sealing performance, accurate content, rapid disintegration, beautiful appearance, etc. is selected. The raw powder and water extraction technology in an original preparation method is no longer used, and a full extraction method for extracting all medicinal materials with alcohol is used. The extraction rate of the effective components of the medicinal materials is increased, and simultaneously, the effective component content of prescriptions is optimized. The medicinal material consumption is saved, and the amount of raw medicines taken by a patient is reduced. The naodesheng soft capsule novel formulation is an invention item with high technology content and technology added value.
This study will test prebiotic fiber in 20 adults who are receiving broad-spectrum antibiotics in the medical or surgical ICU by open-label randomization of patients to approximately 20 g prebiotic fiber/day including 45% short-chain fructooligosaccharides versus 0 g fiber/day by providing one of two feeds. Per 10 ounces of feed, both the high and low fiber feeds contain identical micronutrients and have 296 kilocalorie (kCal), 19 g protein, 8 g fat, and 39 g carbohydrates. The sole difference is that the fiber-containing feed has 4 g fiber including 45% short-chain fructooligosaccharides per 10 ounces whereas the other feed has 0 g fiber. Randomization will take place at the time the order for enteral feeding is placed. Rather than supplying the feed itself, the investigators will supply a randomized recommendation for a feed type (i.e., high vs low fiber) and the feed will be obtained from the hospital pharmacy in the usual manner. Determination of the feed rate and duration will be decided on the individual patient's needs by the treating ICU team. The primary outcome will be to determine whether high fiber feeds alter the gut microbiome in the face of antibiotics and critical illness, calculated by comparing within-individual microbiome differences from baseline to Day 3 in each intervention group.
The characteristics of the sample will be monitored to assure that each category of skin type (I- VI) is accrued in sufficient size to support analysis. In addition, the sample will have equal representation from 4 ethnic groups within each skin type category: African American, Asian, Hispanic, or non-Hispanic White. Participants will self-identify as being Asian, Black, Hispanic Black, Hispanic White, or non-Hispanic White.
The invention relates to a medicine for treating burns and scalds and a preparation method thereof. Sometimes, the epidermis layer is injured during burns and scalds, the injured skin becomes red and swells, a user feels a burning pain, but no bubbles exist. Sometimes, the corium layer is injured during burns and scalds, the skin is locally red and swells, a user cannot bear the pain, and obvious bubbles exist. If burns and scalds are treated in time, negative effects are avoided. The medicine is prepared by combining cirsium japonicum, folium artemisiae argyi, common cephalanoplos herbs, granatum, radix sanguisorbae, amber, ramie roots, radix dipsaci, sophora japonica, concha margaritiferallsta, cacumen biotae, pearl, herba agrimoniae, sculellaria barbata, rhizoma bletillae, rhizoma bletillae, crinis trachycarpi, belvedere fruit, notoginseng, talc, purple perilla, folium isatidis, mulberry leaves, dandelions, duckweed, honeysuckle, gypsum, radix lithospermi, radix trichosanthis and gypsum rubrum. The medicine materials are combined and have a synergistic effect, and therefore burns and scalds can be effectively treated.
In this arm of the study, participants will receive intracavernosal injections of autologous adipose tissue-derived stem cells (ADSC). The ADSC are collected from the participant's own body fat through a minimally invasive liposuction procedure. After processing, the stem cells will be injected directly into the erectile tissue of the penis. This treatment aims to improve erectile function by stimulating tissue regeneration and enhancing blood flow. Participants will be monitored for safety and efficacy, including erectile function assessments using the International Index of Erectile Function (IIEF) and penile hemodynamics measured by Doppler ultrasound. Follow-up evaluations will occur at 3, 6, 9, and 12 months post-treatment.
The study is two-fold. In the preliminary study, the standard and test cakes (chia added cake, flax seed added cake, and chia+flax seed added cake) were developed and the amount of cake containing 50 g carbohydrate and the amount of moisture, ash, pulp, protein, fat, and digestible carbohydrate will be determined via analyses that will be carried at Toros University Food Chemistry Laboratory. Based on the results obtained, the amount of cakes containing 50 g digestible carbohydrate will be calculated and produced.
Provided are mechanisms and processes for predicting infant sleep patterns. Measurement data is received from multiple infant monitoring systems. The multiple infant monitoring systems each include an infant monitoring device and an infant monitoring hub. The infant monitoring device is configured to gather measurement data for an infant and the monitoring hub is configured to process the measurement data. The measurement data is analyzed to identify sleep patterns associated with the plurality of infant monitoring systems. The sleep patterns include sleep transitions, wake transitions, sleep durations, and wake durations over a period of time for infants of various ages. A model is generated based on the sleep patterns associated with infants of various ages. The model is used to predict upcoming sleep patterns for a first infant based on recent measurement data associated with the first infant.
Stroke is an acute cerebrovascular disease in which blood flow to the brain is suddenly disrupted, causing damage to nerve cells. It involves complex and diverse pathophysiological processes and the treatment strategies are also diverse. The treatment for patients with stroke and atrial fibrillation (AF) is aimed at suppressing thrombus formation and migration. However, information regarding the protein networking involved in different thrombus formation pathways in patients with AF and stroke is insufficient. We performed protein profiling of patients with ischemic stroke with and without AF to investigate the mechanisms of thrombus formation and its pathophysiological association while providing helpful information for treating and managing patients with AF. These two groups were compared to identify the protein networks related to thrombus formation in AF. We observed that patients with ischemic stroke and AF had activated inflammatory responses induced by C-reactive protein, lipopolysaccharide-binding protein, and alpha-1-acid glycoprotein 1. In contrast, thyroid hormones were increased due to a decrease in transthyretin and retinol-binding protein 4 levels. The mechanism underlying enhanced cardiac activity, vasodilation, and the resulting thrombosis pathway were confirmed in AF. These findings will play an essential role in improving the prevention and treatment of AF-related stroke.
The invention discloses a blood coagulation-observing capsule which is prepared by utilizing the targeted hemostasis main treatment function of Chinese herbal medicine radish fruit villus seeds and the compatible rhizoma atractylodis root bacteriostasis auxiliary function, is convenient to popularize and is beneficial to medical and civilian treatment. The regional climate condition of the vast population in China is greatly different, the life and labor factors of people are many, people all have trauma experience, and the urban and rural medical conditions have certain limitations. The pharmacopoeia states that herbs have hemostatic property, and the selection and test show that they are not effective enough. Especially, the bleeding of a large wound is not only limited, but also the medical cost is increased if the patient is not hospitalized in time. The invention aims to overcome the defects, explores the way that Yunnan artemisinin can be specially selected by the resident professor to overcome malaria, deeply explores the special efficacy of a certain part of Chinese herbal medicine, and has the advantages of novel and unique blood coagulation main treatment components and novel and obvious effect of compatible components. Natural package, low cost, easy production and convenient carrying. Applying blood for 10-20 seconds to stop blood immediately in a minimally invasive way; the wound depth is less than or equal to 1.5m, the length of the wound is less than or equal to 1.5cm, the wound can stop bleeding and clot within 1-2 minutes without sewing, the wound can be healed within several days, the wound can be naturally decrusted, and the medicine has no toxic or side effect on the human body.
Patients will also be counseled about blood draws, which will include withdrawal of up to 20 mL of blood. Patients who are eligible and agree to participate will sign a consent form. Arm measurements, height and weight, blood draw (if applicable), and baseline questionnaire will be performed at first contact if possible, or at a follow-up scheduled visit prior to surgery.
This study used a quasi-experimental design. Quantitative data from Grade 5 students from five francophone elementary schools in the province of New Brunswick, Canada, who participated in the "Apprenti en Action" culinary program were compared to those of Grade 5 students from five other elementary schools who did not receive the program. "Apprenti en Action" consists of six, one-hour culinary workshops offered once a week during school hours. The program aims to teach students how to read and follow recipes, prepare and cook various foods using various culinary techniques, and apply food safety practices. Students are also taught the basics of healthy food, nutrition, and cooking.

A questionnaire was developed based on previously-validated questionnaires and it measured vegetable and fruit consumption, breakfast consumption, concepts of food literacy including food and cooking skills as well as nutrition knowledge. All students will complete this self-administered online questionnaire before and after the program. Multilevel regressions will be used to assess the effectiveness of the culinary class on students' food literacy, breakfast, vegetable, and fruit consumption. Additionally, focus groups with children who participated in the "Apprenti en Action" program and their parents will be invited to share their perceptions of the program and how/if it has impacted the children's food literacy and eating behaviors.
The effect of simultaneous application of tert-butyl hydroperoxide (tBHP) and polychromatic near-infrared (NIR) radiation on bovine blood was examined to determine whether NIR light decreases the susceptibility of red blood cells (RBCs) to oxidative stress. The study assessed various exposure methods, wavelength ranges, and optical filtering types. Continuous NIR exposure revealed a biphasic response in cell-free hemoglobin changes, with antioxidative effects observed at low fluences and detrimental effects at higher fluences. Optimal exposure duration was identified between 60 s and 15 min. Protective effects were also tested across wavelengths in the range of 750-1100 nm, with all of them reducing hemolysis, notably at 750 nm, 875 nm, and 900 nm. Comparing broadband NIR and far-red light (750 nm) showed no significant difference in hemolysis reduction. Pulse-dosed NIR irradiation allowed safe increases in radiation dose, effectively limiting hemolysis at higher doses where continuous exposure was harmful. These findings highlight NIR photobiomodulation's potential in protecting RBCs from oxidative stress and will be helpful in the effective design of novel medical therapeutic devices.
Patients will be divided into 2 groups according to the random numbers table, and both groups will receive a conventional physical therapy and rehabilitation program and nutritional support. Afterwards, edema-reducing kinesiotaping will be applied to one group. The applied kinesio tape will remain on the patient for 5 days and will be taped again after 2 days without tape. In this way, taping will be done 3 times in total, once a week for 3 weeks. During this period, patients will continue their routine physical therapy program and measurements will be taken by the same researcher in the 1st week of treatment and 3 weeks later.

Kinesiology tapes have a wavy structure in line with the structure and physiological functions of the skin and have adhesive properties. The adhesive is a heat-activated acrylic. After approximately 20 minutes, the adhesive is fully activated. The tapes are porous, permeable to air and liquid, allow perspiration and dry quickly.Kinesiology tapes have a wavy structure in line with the structure and physiological functions of the skin and have adhesive properties. The adhesive is a heat-activated acrylic. After approximately 20 minutes, the adhesive is fully activated. The tapes are porous, permeable to air and liquid, allow perspiration and dry quickly. The method of application varies depending on the cutting method, application direction and region of the tape. If the anatomy of muscles, joints, ligaments and circulatory system is mastered and the correct techniques appropriate to the situation are used, the chance of success of the technique increases. Lymphatic correction technique is used to reorganize damaged lymphatic circulation. The main goals are to create a dead space in the tissue that allows circulation and to reduce the pressure on the lymph vessels at the tissue level. It directs lymph fluid to larger lymphatic vessels and lymph nodes. This effect can be explained by the elastic qualities and lifting effect of the tape. While lifting the surface skin reduces pressure and ensures lymphatic circulation, the tape provides a massage effect during active movement. Thanks to the tape, maximum contraction and relaxation of the muscles is ensured and the effectiveness of the deeper lymphatic flow is increased.

Kinesiophobia (also known as fear of movement); It is defined as an excessive and irrational fear of physical movement to avoid being harmed or injured again. It can also be expressed as an excessive, irrational fear of physical movement and activity resulting from a feeling of vulnerability due to pain. Its prevalence in chronic pain varies between 50-70%. While the existing threatening characteristics of the pain experience may vary depending on the situation and the person, avoidance behavior, which is protective in the short term, paradoxically worsens the problem in the long term. It is stated that kinesiophobia is an important factor in the transition of pain from acute to chronic stages.
Abnormal connectivity patterns interfere with the normal function of a given neuronal network, thus leading to circuit dysfunction and, subsequently, chronic pain. In the last few years, neuroscience has been heavily influenced by network science. This synergistic association provided a new framework for understanding brain function in health and how dysfunction in specific neuronal brain circuits can lead to symptoms. A network comprises nodes (e.g., areas of the brain) and edges (functional connections between nodes). An effective network can process and share large amounts of information while maintaining specificity and not allowing noise to contaminate the flow of information across the circuits. The network approach to brain functioning has been able to integrate what has been known for several decades as spatial structural anatomy with the time-varying streaming of information (connectivity) in a dynamic perspective. In this context, symptoms of diseases are seen as being correlated with specific network abnormalities, and therapeutic interventions as being associated with the normalisation of these abnormal patterns of connection. This study will investigate the responses of specific neuronal brain circuits to experimental heat pain in healthy volunteers. It has been hypothesised that the local-to-global connectivity pattern obtained by the stimulation of different cortical hubs (e.g., the primary motor and dorsolateral prefrontal cortices) will be described by TMS-EEG responses in healthy individuals, and the modification in cortical connectivity in experimental models will be described and compared it with a non-painful sensory stimulation of the same salience.
Provided are among others novel epitopes, methods for finding these epitopes and binding molecules capable of binding to said novel epitopes. In one aspect the invention provides a binding molecule capable of specifically binding to a preferably, post-translationally modified, disease associated molecular marker, associated with diseased cells, whereas said preferably post-translationally modified disease associated molecular marker is not associated with non-diseased cells. In a preferred aspect of the invention, said binding molecule recognizes an epitope present in a subset of CD46 proteins. Said binding molecule is capable of distinguishing between CD46 proteins belonging to the subset and CD46 proteins not belonging to the subset. The binding molecule is preferably an antibody. Medicaments and uses of binding molecules are provided.
Participants received Fingolimod 0.5 mg capsules orally once daily for 12 weeks. At Week 6 of study treatment participants received a seasonal influenza vaccination and a tetanus booster vaccination.
Hydromorphone hydrochloride tablets pose little risk of direct exposure to healthcare personnel and should be handled and disposed of prudently in accordance with hospital or institutional policy. Significant absorption from dermal exposure is unlikely. Patients and their families should be instructed to flush any hydromorphone hydrochloride tablets that are no longer needed.

Access to abusable drugs such as hydromorphone hydrochloride tablets presents an occupational hazard for addiction in the healthcare industry. Routine procedures for handling controlled substances developed to protect the public may not be adequate to protect healthcare workers. Implementation of more effective accounting procedures and measures to restrict access to drugs of this class (appropriate to the practice setting) may minimize the risk of self-administration by healthcare providers.
In addition to receiving all the components of HTN-BASIC, HTN-PLUS sites will receive an enhanced, more human-resource intensive package of interventions that have been developed in consultation with key stakeholders during our human-centered design phase. The intervention components will include four broad categories- (1) hypertension training, (2) differentiated service delivery and (3) remote patient monitoring for hypertension and (4) Performance Improvement Program. Uptake of all components will be assessed on a monthly basis during the intervention period. These interventions will by nature cost more, and so cost data will be rigorously collected as well.