anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In addition to adverse reactions reported from clinical trials, the following adverse reactions have been identified during postapproval use of salmeterol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, or causal connection to salmeterol or a combination of these factors. 

In extensive US and worldwide postmarketing experience with salmeterol, serious exacerbations of asthma, including some that have been fatal, have been reported. In most cases, these have occurred in patients with severe asthma and/or in some patients in whom asthma has been acutely deteriorating [see Warnings and Precautions (5.2)], but they have also occurred in a few patients with less severe asthma. It was not possible from these reports to determine whether salmeterol contributed to these events.

Cardiovascular: Arrhythmias (including atrial fibrillation, supraventricular tachycardia, extrasystoles) and anaphylaxis.

Non-Site Specific: Very rare anaphylactic reaction in patients with severe milk protein allergy.

Respiratory: Reports of upper airway symptoms of laryngeal spasm, irritation, or swelling such as stridor or choking; oropharyngeal irritation.
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
BACKGROUND/AIM: Adequate knowledge, attitude, and self-care practice (KAP) are paramount in reducing diabetes complications. This study examined diabetes-related KAP in individuals who have been previously reported to be at a higher risk of blindness such as those on insulin treatment or with a longer (>6 years) duration of diabetes in Bangladesh.
METHODS: Six hundred community-dwelling individuals (mean age = 52.7±11.6 years) who had been diagnosed with diabetes by their doctor were interviewed. A semi-structured questionnaire obtained self-reported information about diabetes-related KAP, duration, treatment of diabetes, and sociodemographic parameters including age, gender, and education level. Data were collected using a purposive sample technique and analyzed using Fischer's exact test or independent samples t-tests.
RESULTS: There were 271 males (45.2%) and 329 (54.8%) females. Of the total participants (mean diabetes duration = 6.6±6.2 years), 36.5% had diabetes for more than the median duration of 6 years, 80.7% were receiving insulin or insulin combined with tablets (insulin group) and the remaining 19.3% were on tablet only and/or diet control (non-insulin group). One-fifth (19.8%) of all the participants did not consider diabetes a serious disease, 31.3% were unaware that uncontrolled diabetes can cause blindness, 40.5% had never had their eyes tested for diabetic retinopathy and 41.5% stated that they would not attend diabetic retinopathy screening until their eyesight became worse. Among those in the insulin group, 42.1% reported being unaware that smoking may be harmful to diabetes compared to 30.2% of those in the non-insulin group (p= 0.02). Additionally, 64.7% of those in the insulin group were unaware that a diabetic retinal screening is different from a routine eye test for spectacles, compared to 44.8% in the non-insulin group (p< 0.001). Sixty-two percent of participants with diabetes duration of more than 6 years reported that diabetes management was a shared responsibility between the doctor and the patient compared to 48.3% with a shorter duration (p< 0.001). Those with a longer duration of diabetes (>6 years) also reported forgetting to take their medication more often than those with a shorter duration (p = 0.02). Twenty-one percent of participants with a duration of diabetes longer than six years had checked their eyes within the previous year compared to 63.5% of those with a shorter duration of diabetes (p< 0.001).
CONCLUSION: Individuals on insulin treatment demonstrated poorer knowledge and awareness of diabetes and diabetes eye screening. Those with a longer diabetes duration exhibited poorer self-care practices, particularly not taking the medication regularly, and neglecting diabetic retinal checkups. These issues need to be addressed in designing targeted educational interventions to prevent blindness from uncontrolled diabetes in the high-risk groups in Bangladesh.
Nowadays, chronic kidney disease (CKD) prevalence keeps increasing worldwide. The management of these patients usually requires renal replacement therapy (RRT). However, the complexity of patients' profiles comprises a great challenge to overcome. During the last decades, CKD units have been developed to offer multidisciplinary and coordinated attention to patients, helping in the decision-making of the RRT. Nevertheless, there is a huge variability in the performance and organization of care practice, implying an existing necessity to homogenize the RRT modality chosen. We propose a test composed of two parts: one to be completed by the medical staff (to evaluate contraindications for the different RRT techniques) and another by the patient or nursing staff (to consider patients' preferences). In this sense, it would be possible to have a common and useful tool to complement patient education in RRT, as well as sharing decision-making in the ACKD units taking into account patient preferences.
AIMS: We aimed to investigate the anxiolytic effect of darbepoetin alpha (DEPO), an erythropoietin derivative, in a neuroinflammation model regarding different behaviors and biological pathways.
METHODS: Forty adult male Wistar albino rats were divided into four groups (control, LPS, DEPO, and DEPO + LPS). The rats were treated with 5 µg /kg DEPO once a week for four weeks, after which neuroinflammation was induced with 2 mg/kg lipopolysaccharide (LPS). The elevated plus maze, open-field, and light‒dark box tests were conducted to assess anxiety levels. Harderian gland secretions were scored via observation. Tumor necrosis factor alpha (TNF-α), Interleukin-1-beta (IL-1β), brain-derived growth factor (BDNF), serotonin, cortisol, total antioxidant/oxidant (TAS/TOS), and total/free thiol levels were measured in the prefrontal cortex, striatum, and serum.
RESULTS: DEPO had a potent anxiolytic effect on both DEPO and DEPO + LPS groups. Compared to the control group, DEPO administration caused an increase in serotonin and BDNF levels and decreased basal cortisol and TNF-α levels in naive rats. IL-1β did not alter after DEPO administration in naive rats. Prophylactic DEPO treatment remarkably downregulated cortisol, IL-1β, and TNF-α in the DEPO + LPS group. In addition, prophylactic DEPO administration significantly attenuated the decrease in serotonin and BDNF levels in the DEPO + LPS group. Furthermore, DEPO ameliorated excessive harderian gland secretion in the DEPO + LPS group. Compared with those in the control group, the free thiol content in the serum increased after DEPO administration. No similar effect was seen in the DEPO + LPS group receiving prophylactic DEPO. TAS showed no difference among all experimental groups. DEPO administration increased TOS and OSI in the serum and prefrontal cortex but not in the striatum. This effect was not seen in the DEPO + LPS group.
CONCLUSION: Darbepoetin alpha had an anxiolytic effect on many physiological mechanisms in a neuroinflammation model and naive rats.
This group of patients will receive: 1 mg/Kg ketamine + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia. Endotracheal tube will be inserted aided by 1 mg/Kg succinyl choline. Patients will undergo surgical procedure to eliminate the source of sepsis e.g. abdominal exploration. Invasive blood pressure monitor will be connected to the patient through an arterial catheter. Electrical velocimetry (cardiometry) device will be connected to the patient to measure cardiac output, stroke volume, and systemic vascular resistance.
The invention discloses a traditional Chinese medicine composition for treating gynecological uterine bleeding. The traditional Chinese medicine composition for treating the gynecological uterine bleeding is prepared from, by weight, 18-25 parts of plantain seeds, 18-22 parts of lalang grass rhizome, 18-25 parts of lotus rhizome nodes, 13-17 parts of Japanese thistle herbs, 13-18 parts of herba agrimoniae, 28-33 parts of crinis carbonisatus and 4-8 parts of licorice roots. The preparation method of the traditional Chinese medicine composition comprises the steps that the raw materials are put into a decocting pot, water is added to cover the raw materials, decocting is conducted through small fire for 30-60 min after boiling is conducted through big fire, juice is extracted, and the traditional Chinese medicine composition for treating the gynecological uterine bleeding is obtained. The taking method comprises the steps of taking the composition once every morning and night on an empty stomach. According to the traditional Chinese medicine composition for treating the gynecological uterine bleeding, the plantain seeds nourish the lung, reinforce Yin and enrich essence, the lalang grass rhizome cools the blood for hemostasis, clears heat and induces diuresis, the lotus rhizome nodes astringe and stop bleeding and remove blood stasis, the Japanese thistle herbs cool the blood for the hemostasis, remove blood stasis and promote the subsidence of swelling, the herba agrimoniaes stops the blood and resist bacteria, the crinis carbonisatus stops the blood, removes blood stasis and resists the bacteria, and the licorice roots diminish inflammation, resist allergy and regulate hormone content in the body of a woman. The raw materials are combined, the gynecological uterine bleeding is treated, the curative effect is obvious, the raw materials are low in price, and the traditional Chinese medicine composition for treating the gynecological uterine bleeding is suitable for promotion.
In the case-control study, prediabetes was diagnosed according to the diagnostic criteria recommended by the WHO in 1999. Prediabetes was defined as impaired fasting glucose (FPG ≥6.1 mmol/L and \<7.0 mmol/L, and 2-h post-glucose load \<7.8 mmol/L) and/or impaired glucose tolerance (FPG \<6.1 mmol/L, and 2-h post-glucose load ≥7.8 mmol/L and \<11.1 mmol/L). In the nested case-control study, new-onset prediabetes was defined as FPG ≥6.1 mmol/L and \<7.0 mmol/L.
A tablet system for prolonged floating in or on gastric fluid for releasing therein pharmaceutically active substances in an alternate succession of substance release and no-release periods is made up of a multilayered core placed in a cup-shaped envelope. The core is made up of release layers and no-release layers devoid of pharmaceutically active substance, superposed in alternate succession. The cup-shaped envelope covers bottom and side surfaces of the core while leaving exposed an upper surface of the core. The cup-shaped envelope provides for buoyancy by being formed of a compression-sintered mixture comprising hydrophobic material and inert powdered filler. The hydrophobic material is composed of fatty and/or waxy material capable of being sintered by compression and whose bulk density is lower than gastric fluid density. The powdered filler has a loose powder density that is lower than gastric fluid density.
Participants will have access to an intervention between pre-test and post-test assessments. The intervention, DigiKnowIt News: Teen, is an educational website designed to teach youth (12-17 years) about pediatric clinical trials and give parents and youth resources for communication and shared decision-making about research.
PURPOSE:To obtain an external dermatic medicine resistant to coloration with time by compounding sodium bisulfite and/or hydrogen peroxide together with a kojic acid (derivative). CONSTITUTION:The objective medicine is prepared by compounding kojic acid or a kojic acid derivative (e.g. monoester or diester) together with 0.001-20.0wt.%, preferably 0.5-5.0wt.% (based on kojic acid) of sodium bisulfite and/or hydrogen peroxide. The above compound is preferably added at the final stage of the preparation of the objective medicine, i.e., after the completion of heating stage. The kojic acid is e.g. pure kojic acid, a fermentation liquid composed mainly of kojic acid and produced by the culture of a microbial strain capable of producing kojic acid, a concentrated liquid of the fermentation liquid, kojic acid extracted and crystallized from the fermentation liquid, etc.
OBJECTIVE: To compare the effects of warm and cold dialysate solutions on the duration of post-dialysis fatigue in patients undergoing maintenance haemodialysis.
METHODS: The quasi-experimental study was conducted at the Department of Nephrology, Pak Emirates Military Hospital, Rawalpindi, Pakistan, from May 9 to September 10, 2023, and comprised adult patients of either gender undergoing maintenance haemodialysis for a minimum of 3 months. The patient initially underwent haemodialysis with a dialysate temperature of 36°C for 2 weeks. During the subsequent washout period of one week when the dialysate temperature was not monitored, they underwent haemodialysis with a dialysate temperature of 37°C for another 2 weeks. Blood pressure was monitored every 30 minutes to record any hypotensive episodes. Patients were asked if they felt fatigued after the last haemodialysis session, and the duration was noted down. Data was analysed using SPSS 24.
RESULTS: Of the 92 patients with mean age 49.1±16.1 years, 57(62%) were males. Post-dialysis fatigue was seen in 67(72.8%) and 75(81.5%) patients with dialysate temperatures at 36°C and 37°C, respectively (p<0.001). The duration of post-dialysis fatigue was also significantly longer at dialysate temperatures 37°C p<0.001). There was no significant difference in the proportion of hypotensive episodes in the two groups (p=0.445).
CONCLUSION: Dialysate temperature 36°C was found to be associated with less frequent and shorter duration of postdialysis fatigue compared to dialysate temperature 37°C.
The invention provides an external fuming and washing traditional Chinese medicine for treating damp-heat type skin eczema. Aiming at pathogenesis of damp-heat type eczema, the external fuming and washing traditional Chinese medicine is a traditional Chinese medical preparation decocted by 50-100 parts of hyacinth dolichos leaves, 150-250 parts of hyacinth dolichos vines, and 100-150 parts of hyacinth dolichos root. The external fuming and washing traditional Chinese medicine fundamentally invigorates spleen and stomach and clears heat and promotes diuresis as well as dispels wind and detoxify. By way of fuming and washing, the hot liquid medicine is fumed or steamed by steam and is directly contacted with skins of affected regions, so that the function of the medicine for relieving summer heat and promoting diuresis, and detoxifying and removing swelling can be enhanced; and the medicine can reach the focus directly, and the utilization of effective components of the medicine is enhanced, so that not only is loss to skins in the treatment process reduced, but also an ideal treating effect is obtained. The external fuming and washing traditional Chinese medicine provided by the invention is remarkable in curative effect for treating damp-heat type skin eczema and free from side effect and dependency, and pains of patients are alleviated. When the external fuming and washing traditional Chinese medicine provided by the invention is used for treating 28 patients with damp-heat type skin eczema, 22 patients are cured after one course of treatment, and 6 patients are improved, so that the cure rate is 79% and the effective rate is 100%.
At the expansion phase: Revlimid 20 mg (days 1-21), Doxil 30 mg/m2 on Day 1 and Avastin 15 mg/kg on Day 1, every 3 weeks. If this regimen is not cumulatively tolerable, Avastin will be administered every other course. Patients will be received up to 6 cycles or disease progression, followed by Revlimid maintenance at 25 mg PO q Day for 3 weeks every 4 weeks in patients with stable disease.
Patients undergo clinical observation for 12 weeks. If PSA continues to increase, patients have the option to receive the white button mushroom extract as in arm IA.
Studying the intricate relationship between miRNAs and diseases is crucial to prevent and treat miRNA-related disorders. Existing computational methods often overlook the importance of features of different nodes and the propagation of features among heterogeneous nodes. Many prediction models focus only on the feature coding of miRNA and diseases and ignore the importance of feature aggregation. We propose a prediction method via dual-neighbourhood feature aggregation and feature fusion, which uses multiple sources of information, aggregates information on homogeneous and heterogeneous nodes and fuses learned features to predict multiple representations of disease nodes. We constructed similarity networks of multiple homogeneous nodes based on different similarity computation methods respectively, and fused the attention mechanism by using graph convolutional networks to obtain information of different levels of importance. To alleviate the problem of sparse connectivity in the dataset, we built a two-neighbourhood heterogeneous graph neural network model to integrate the homogeneous similarity network into a miRNA-disease heterogeneous network by using known miRNA-disease association information. We used the neighbourhood information associated with the nodes in the network to perform feature aggregation. In addition, we used a feature fusion module to learn the importance of different types of nodes to predict miRNA-disease associations. Our experimental results on the Human microRNA Disease Database (HMDD v3.2) show that the model demonstrates superior performance. This work demonstrates the capability of our model to identify potential miRNAs associated with diseases through a case study of two common cancers.
Subjects in this group will take 50mg of meclizine daily for the three weeks prior to their quit date. Subjects will also apply a 21mg/24h nicotine patch daily starting in the second week of pre-quit treatment. Meclizine will be administered in two doses each day.
Release of components of a resin composite system containing pre-reagent vitreal particles: laboratory and patient studies. The objectives of this study was to evaluate physical and chemical properties of a methacrylate-based restorative system regarding to the release of resin components to the storage medium, to evaluate the clinical performance of composite resin restorations, considering also the evaluation of release of resin components into saliva and the presence of cytokines in gingival crevicular fluid. Restorative system FL-Bond II (self-etching adhesive system)/ beautifil II (composite restorative) were use. For in vitro assays, adhesive and resin specimens are being preparing for assessing the monomers degree of conversion (by FTIR), sorption and solubility and release of resinous components in ethanol and Ringer solutions (through a gas chromatography and mass spectroscopy - GC-MS). In the longitudinal clinical study, patients who present a NCCL with restorative need were selecting. Prior to treatment, there will be periodontal evaluation, saliva and gingival crevicular fluid collection (controls). The lesions were restoring with the restorative system. After 10 min,7 days, 1 and 6 months, clinical performance of restorations and periodontal response were evaluate according to the criterion FDI. Additionally, in all of these evaluation periods samples of saliva and crevicular fluid are being collecting. Saliva samples will be analyze by GC-MS to identify the eventual presence of organic components derived from the restoration. The crevicular fluid samples were analyzing using ELISA for identification and quantification of interleukins.
The present invention relates to an external application Chinese patent drug for curing osteoarthropathy and a preparation technology thereof. The external application Chinese patent drug is prepared from the components of the following weight percentage: 20 to 40% of gardenia, 10 to 25% of safflower, 5 to 20% of dried ginger and 20 to 40% of rhizoma drynariae, and the rest is edible starch. In the preparation technology, the gardenia, the safflower, the dried ginger and the rhizoma drynariae are dried and ground into powder, and the mesh number of the powder is controlled above 80 meshes; after being jointly mixed, the raw material powder and the edible starch are added with spirits, vinegar and distilled water, coordination is carried out so as to preferablely coordinate the raw material traditional Chinese drug powder into a paste shape, and a crude product of the present invention is obtained. The crude product in a paste shape is put in a sealed container for making the crude product stand for at least three days, and the Chinese patent drug of the present invention is obtained. After being used, the Chinese patent drug of the present invention can rapidly relieve inflammation and dropsy edema caused by root compression so as to make the protruded intervertebral cartilages rapidly fold and recover. The Chinese patent drug of the present invention successfully achieves the cure of manifestation and root cause of diseases, can make diseases do not recur, and has no toxic or side effect on human bodies. The Chinese patent drug of the present invention has the advantages of low cost, short cure course, obvious curative effect and broad market prospect.