anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants received intravenous infusions of placebo in combination with carboplatin to achieve an initial target AUC of 5 mg/mL/min followed by etoposide 100 mg/m\^2 on Day 1 of every 21-day cycle during the induction phase (Cycles 1-4). On Days 2 and 3 of every 21-day cycle during the induction phase (Cycles 1-4), etoposide 100 mg/m\^2 was administered alone. Thereafter, participants received maintenance (Cycle 5 onward) placebo on Day 1 of every 21-day cycle until persistent radiographic PD, symptomatic deterioration, intolerable toxicity, withdrawal of consent, death, or study termination by the Sponsor.
PURPOSE: A cosmetic composition containing Hosta longipes(Fr.et Sav.) Matsumura as an active ingredient is provided to ensure anti-oxidation, skin irritation relief, anti-inflammation, and moisturization. CONSTITUTION: A cosmetic composition contains 0.001-30.0 weight% of Hosta longipes(Fr.et Sav.) Matsumura extract as an active ingredient. A method for preparing the Hosta longipes(Fr.et Sav.) Matsumura extract comprises: a step of extracting Hosta longipes(Fr.et Sav.) Matsumura with 10-95%(v/v) of ethanol solution at 70-85°C and infusing ; a step of filtering the infused extract to obtain filtered liquid; a step of decompressing the filtered liquid under 50°C; a step of freezing the decompressed concentrate; and a step of extracting the dried material with purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, dichloromethane, or hexane.
The learning collaborative as designed will be delivered to this arm during phase I, which will last a period of approximately 9 months. After the 9 months, there will be passive follow-up of this arm to see if outcomes following the first 9 months are sustained.
The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to seabuckthorn fruit peel polysaccharide, and a preparation method and application thereof. The seabuckthorn fruit peel polysaccharide comprises the following monosaccharide components: rhamnose, mannose, galactose, glucose, galacturonic acid and arabinose. The preparation method of the invention is that the water-soluble crude polysaccharide is obtained through degreasing, extracting, concentrating and alcohol precipitating, and then the sea buckthorn peel polysaccharide is obtained through purifying by adopting nonpolar macroporous adsorption resin. The polysaccharide yield is high and the polysaccharide content is high. The invention realizes the enrichment of the sea buckthorn fruit peel active polysaccharide by using nonpolar macroporous adsorption resin to replace DEAE-cellulose and sephadex with higher cost, greatly improves the yield and purity of the polysaccharide, has low production cost, and can be used for industrialized mass production. The seabuckthorn fruit peel polysaccharide provided by the invention has remarkable effects of resisting ulcerative colitis, and improving constipation, dyspepsia and intestinal flora disorder.
Budesonide-formoterol fumarate dihydrate at two dose strengths 80/4.5 and 160/4.5 administered via a pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI), respectively. The dosing will be dependent on asthma symptom severity ranging from 1 dose as needed and titrated up or down depending on asthma control.
UNLABELLED: Cancer stem cells (CSC) play a critical role in metastasis, relapse, and therapy resistance in colorectal cancer. While characterization of the normal lineage of cell development in the intestine has led to the identification of many genes involved in the induction and maintenance of pluripotency, recent studies suggest significant heterogeneity in CSC populations. Moreover, while many canonical colorectal cancer CSC marker genes have been identified, the ability to use these classical markers to annotate stemness at the single-cell level is limited. In this study, we performed single-cell RNA sequencing on a cohort of 6 primary colon, 9 liver metastatic tumors, and 11 normal (nontumor) controls to identify colorectal CSCs at the single-cell level. Finding poor alignment of the 11 genes most used to identify colorectal CSC, we instead extracted a single-cell stemness signature (SCS_sig) that robustly identified "gold-standard" colorectal CSCs that expressed all marker genes. Using this SCS_sig to quantify stemness, we found that while normal epithelial cells show a bimodal distribution, indicating distinct stem and differentiated states, in tumor epithelial cells stemness is a continuum, suggesting greater plasticity in these cells. The SCS_sig score was quite variable between different tumors, reflective of the known transcriptomic heterogeneity of CRC. Notably, patients with higher SCS_sig scores had significantly shorter disease-free survival time after curative intent surgical resection, suggesting stemness is associated with relapse.
IMPLICATIONS: This study reveals significant heterogeneity of expression of genes commonly used to identify colorectal CSCs, and identifies a novel stemness signature to identify these cells from scRNA-seq data.
The present invention is directed to the induction and characterization of a humoral immune response targeting "entry-relevant" gp41 structures. In its broadest aspect, the present invention is directed to methods of raising a neutralizing antibody response to a broad spectrum of HIV strains and isolates. The present invention targets particular molecular conformations or structures that occur at the cell surface of HIV during viral entry into host cells. Such a humoral response can be generated in vivo as a prophylactic measure in individuals to reduce or inhibit the ability of HIV to infect uninfected cells in the individual's body. Such a response can also be employed to raise antibodies against "entry relevant" gp41 structures. These antibodies can be employed for therapeutic uses, and as tools for further illuminating the mechanism of HIV cell entry.
The present invention relates to a method for preparing spleen-invigorating and digestion-promoting soymilk powder with micron chicken's gizzard-skin powder, micron hawthorn powder, micron cactus powder, oligosaccharide and micron pseudostellaria root powder. The micron chicken's gizzard-skin powder, the micron hawthorn powder, the micron cactus powder, the micron pseudostellaria root powder and oligosaccharide raw material processed through high-technology airflow superfine grinding are added into different traditional soymilk powder, combined and fermented into the spleen-invigorating and digestion-promoting soymilk powder. The spleen-invigorating and digestion-promoting soymilk powder has the obvious functions of invigorating spleens and promoting digestion and simultaneously has the effects of alloying fatigue, enhancing immunity, etc. Teenagers and children who have spleen deficiency and general deficiency can obtain scores of nutrient substances such as abundant protein, vitamins, mineral substances, active ferment, etc., and simultaneously, the spleen-invigorating and digestion-promoting soymilk powder strengthens the health-care functions of benefiting qi, promoting blood circulation, invigorating spleens, promoting digestion, etc. of the soymilk powder because the ingredient of the micro cactus powder which is extolled as a faddy dish for promoting qi and activating blood circulation is added. Therefore, the present invention is a favorable method for preparing the spleen-invigorating and digestion-promoting soymilk powder which has Chinese characteristics and is especially designed for the teenagers and the children who have the spleen deficiency and the general deficiency.
This invention provides a cationic polymer for a hair treatment composition. Even though using for the injured hair, it presents an excellent hair-protecting effect. When incorporated in a body detergent composition, it improves lathering and lather quality, and achieves a satisfactory use feeling. The cation modified purified galactomannan polysaccharide constituted of a main chain. It comprises structural units derived from mannose and side chains comprising galactose units. Wherein, the content of galactomannans is 80% by mass or higher and part of the hydroxy groups of the polysaccharide. The mannose versus galactose ratio is 4:1 and/or 3:1. The galactomannans have been replaced with a quaternary-nitrogen-containing group represented by the following chemical formula. (Wherein, R1, R2 represent the alkyl with carbon number C1to 3, R3 represents the alkyl with carbon numbers C1 to 24, X-represents anion; n represents n = 0 or n = 1 to 30. When n = 1 to 30, (R4O)n represents the epoxy paraffin copolymer with carbon numbers C2 to 4, the sole ethylene paraffin polyalkane two mellow chains and/or 2 kind epoxy paraffin polyalkane two mellow chains)
BACKGROUND: The impact of hospital care quality on patient outcomes in post-stroke aphasia remains unclear. We investigated the impact of nationally-endorsed acute stroke treatments on outcomes post-stroke, by aphasia status.
METHODS: Patient-level data from the Australian Stroke Clinical Registry (2009-2013) linked to national deaths, hospital emergency presentations and admissions data were used. Aphasia was identified for the index stroke event (ICD-10 diagnosis code R47.0). Impact of receiving an optimal stroke care bundle (stroke unit care, antihypertensive medication at discharge and discharge care plan) and an acute ischemic stroke (AIS) care bundle (stroke unit care, intravenous thrombolysis and aspirin within 48 h of admission) on outcomes were analysed using multivariable regression models with propensity score adjustment.
RESULTS: The study included 12,690 patients with a median age of 76, 54 % male, and 26 % with aphasia. Non-receipt of the optimal stroke care bundle was associated with worse survival, compared to optimal care, in people with aphasia (HR: 3.37; 95 % CI 2.10, 5.40; p < 0.05) and without aphasia (HR: 2.10; 95 % CI 1.19, 3.69; p < 0.05). Notably, the dose-response effect on survival was more pronounced in individuals with aphasia. In those who received the AIS care bundle, readmission within 12 months was greater in those without aphasia (vs aphasia, p-value interaction = 0.001), whereas survival was similar (p-value interaction = 0.731).
CONCLUSIONS: Survivors of stroke with aphasia who did not receive the optimal stroke care bundle, had worse survival at 12 months post-stroke. Ensuring eligible patients receive the optimal stroke care bundle is crucial for improving their 12-month survival.
The present invention corresponds to the composition of a unique formula to be used as pre-dipping and post-dipping in robot milking in order to control mastitis in bovines. The composition comprises at least one organic zinc salt, water soluble and with biocidal properties, where the concentration of zinc ions is in the range of 5,000 to 60,000 ppm. The salts with biocidal properties were selected for having a functional group similar to proteins. Organic zinc salts are degradable, less irritating to the cow's teat, improve the skin condition, have an anti-inflammatory effect, accelerate wound healing processes and eliminate bacteria and fungi. The organic zinc salts selected for this invention were the following: gluconate, lactate, glycinate, lysinate, citrate trihydrate, picolinate, and acetate. Zinc sulfate monohydrate can be optionally added, but in low concentration, less than 1.5% of the final product. The viscosity of the spray composition should be in the range of 3 to 5 centipoise (cP), at room temperature. Finally, and very importantly, the composition has no corrosive activity on metals and non-metals, such as stainless steel, carbon steel, computer cards and other components found in bovine milking robots.
PURPOSE:To reduce necessary memory capacity by making the succeeding scanning available even if the processing of raw data obtained by an optional scanning is not completed yet and utilizing a storage device inherent in an arithmetic unit to be controlled by a CPU. CONSTITUTION:Scanning S1 is executed, raw data D1 is sent to a 1st buffer memory 7 in a raw data buffer memory 6, and at the time of turning on a switch 8, sent to a 2nd buffer memory 9. The data D1 in the memory 7 are stored in a magnetic disk 5 through the CPU3 and picture constituting operation R is executed in a rapid arithmetic unit 1 through a general bus 10. Since the unit 1 is executing operation at the time of starting scanning S2, the switch 8 is turned off and input data D2 are stored from the memory 7 to a magnetic disk 5. After completing the operation R1 of the unit 1, the CPU3 stores the data D2 from a disk 5 to the memory 9 and the unit 1 starts the operation R2 of the data D2. Thus, the buffer memory is divided into two areas to simultaneously execute the entry of the raw data into the magnetic disk and the picture reconstitution of the arithmetic unit 1.
Patients receive nivolumab IV over 60 minutes on day 1. Beginning days 17-36, patients undergo standard of care surgery.
The hand is capable of performing complex specialized tasks that require dexterity, manipulation, and tactile sensitivity.(Polat, 2023) Hand performance on a task is a combination of different skills, including grip muscle strength, movement, tactile feedback, and motor coordination. (Imamura, Rissanen, Kinnunen, \& Rintamäki, 1998). To achieve these, the hand is equipped with mechanical and sensory abilities.(Dianat, Haslegrave, \& Stedmon, 2012) Dexterity is a motor skill determined by the range of motion of the hands and fingers, as well as the ability to manipulate. It is a combination of reaction time, touch sensation, nerve conduction, grip strength and mobility. While finger dexterity is related to the fine motor skills required to move relatively small objects, manual dexterity includes the gross motor skills required to hold relatively large objects.(Roman et al., 2023) The most common dexterity tests reported in the literature include the Box-Block Test, Purdue Pegboard Test, Jebsen Taylor Test, 9-Hole Peg Test (NHPT), and Roeder Manipulative Ability Test.
Participants in the control group received 12 monthly sham intravitreal injections. The evaluation was performed using the same criteria for dose doubling as in active treatment groups. The injection was a mimicked by an empty syringe without a needle. Laser photocoagulation was permitted as rescue treatment for the study eye after 3 consecutive monthly injections.
These last 10 years, a new idea born: vibrations could have potential effects on muscular reconditioning. Researchers have previously demonstrated the effects on plantar ankle flexion, with the increase of the strength, on healthy volunteers. Nowadays physicians would like to demonstrate the effects on another muscular group: ankle's dorsal flexors. 24 sessions are programmed on 8 weeks.

Moreover, the last results showed a modification of the nervous capacities of the cortical voluntary activation. Transcranial Magnetic Stimulation (TMS) is a great tool to explore the neuromuscular function, at the cortical stage. The use of this tool will allow the characterization the effects of the vibration training on the cortical activation state.
Patients who are randomized to the stocking use group (Treatment Subgroup A) will be formally measured for their stockings by a certified stocking fitter, given (at no charge) two pair of 20-30mmg Hg maternity pantyhose compression stockings, and will undergo a brief tutorial regarding how to put the stockings on. Each patient will be instructed to wear the stockings on a daily basis, during the day.
In this study, subjects were randomly assigned. Through a multi-center research method, a total of 100 eligible subjects were recruited, and their consent was obtained and a subject consent form was signed. The subjects were divided into two groups according to the way of nutritional intervention, including nutritional education (NE) and nutritional supplement drink (NSD), with 50 people in each group. The NE group is given regular nutrition education by qualified clinical nutritionists to ensure the effectiveness of nutrition education. In the NSD group, in addition to nutrition and health education, daily oral supplements (Meiji Mei Balance, Meiji Co., Ltd., Tokyo, Japan) are provided daily, and snacks are supplemented between lunch and dinner and before bedtime, 2 per day. bottle. The two groups were divided into groups by lottery, and the intervention period was 12 weeks. During the intervention period, blood will be drawn at the beginning, 6th, and 12th week of the case, and blood pressure, body position, body composition and muscle strength will be measured, and dietary intake will be assessed. At the same time, a quality of life survey will also be conducted. survey, QoL survey.

Moreover, we recruited 50 healthy elderly to investigate and compare the nutritional status, serum zinc and vitamin D status in healthy elderly and at risk of malnutrition elderly. This group was considered as a control group and we didn't do any intervention after blood collection and physical measurements.
Increased serum cholesterol and triglycerides, requiring the need for anti-lipid therapy, have been reported to occur following initiation of everolimus and the risk of hyperlipidemia is increased with higher everolimus whole blood trough concentrations [see Adverse Reactions (6.2)]. Use of anti-lipid therapy may not normalize lipid levels in patients receiving everolimus.

Any patient who is administered everolimus should be monitored for hyperlipidemia. If detected, interventions, such as diet, exercise, and lipid-lowering agents should be initiated as outlined by the National Cholesterol Education Program guidelines. The risk/benefit should be considered in patients with established hyperlipidemia before initiating an immunosuppressive regimen containing everolimus. Similarly, the risk/benefit of continued everolimus therapy should be reevaluated in patients with severe refractory hyperlipidemia. Everolimus has not been studied in patients with baseline cholesterol levels greater than 350 mg/dL.

Due to an interaction with cyclosporine, clinical trials of everolimus and cyclosporine in kidney transplant patients strongly discouraged patients from receiving the HMG-CoA reductase inhibitors simvastatin and lovastatin. During everolimus therapy with cyclosporine, patients administered an HMG-CoA reductase inhibitor and/or fibrate should be monitored for the possible development of rhabdomyolysis and other adverse effects, as described in the respective labeling for these agents [see Drug Interactions (7.7)].
Memory impairment is a serious problem with organismal aging and increased social pressure. The tetrapeptide Ala-Phe-Phe-Pro (AFFP) is a synthetic analogue of Antarctic krill derived from the memory-improving Antarctic krill peptide Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg (SSDAFFPFR) after digestion and absorption. The objective of this research was to assess the neuroprotective effects of AFFP by reducing oxidative stress and controlling lipid metabolism in the brains of mice with memory impairment caused by scopolamine. The 1H Nuclear magnetic resonance spectroscopy results showed that AFFP had three active hydrogen sites that could contribute to its antioxidant properties. The findings from in vivo tests demonstrated that AFFP greatly enhanced the mice's behavioral performance in the passive avoidance, novel object recognition, and eight-arm maze experiments. AFFP reduced oxidative stress by enhancing superoxide dismutase activity and malondialdehyde levels in mice serum, thereby decreasing reactive oxygen species level in the mice hippocampus. In addition, AFFP increased the unsaturated lipid content to balance the unsaturated lipid level against the neurotoxicity of the mice hippocampus. Our findings suggest that AFFP emerges as a potential dietary intervention for the prevention of memory impairment disorders.
OBJECTIVE: The objective of this study was to examine the association of cardiorespiratory events, including apnea, periodic breathing, intermittent hypoxemia (IH), and bradycardia, with late-onset sepsis for extremely preterm infants (<29 weeks of gestational age) on vs off invasive mechanical ventilation.
STUDY DESIGN: This is a retrospective analysis of data from infants enrolled in Pre-Vent (ClinicalTrials.gov identifier NCT03174301), an observational study in 5 level IV neonatal intensive care units. Clinical data were analyzed for 737 infants (mean gestational age: 26.4 weeks, SD 1.71). Monitoring data were available and analyzed for 719 infants (47 512 patient-days); of whom, 109 had 123 sepsis events. Using continuous monitoring data, we quantified apnea, periodic breathing, bradycardia, and IH. We analyzed the relationships between these daily measures and late-onset sepsis (positive blood culture >72 hours after birth and ≥5-day antibiotics).
RESULTS: For infants not on a ventilator, apnea, periodic breathing, and bradycardia increased before sepsis diagnosis. During times on a ventilator, increased sepsis risk was associated with longer events with oxygen saturation <80% (IH80) and more bradycardia events before sepsis. IH events were associated with higher sepsis risk but did not dynamically increase before sepsis, regardless of ventilator status. A multivariable model including postmenstrual age, cardiorespiratory variables (apnea, periodic breathing, IH80, and bradycardia), and ventilator status predicted sepsis with an area under the receiver operator characteristic curve of 0.783.
CONCLUSION: We identified cardiorespiratory signatures of late-onset sepsis. Longer IH events were associated with increased sepsis risk but did not change temporally near diagnosis. Increases in bradycardia, apnea, and periodic breathing preceded the clinical diagnosis of sepsis.
Induction therapy: ATO and ATRA, which will maintain until complete hematologic remission. Hydroxyurea should be administrated until WBC count decrease \<10x109/L. Consolidation therapy: RIF（60mg/kg/d) and ATRA 4 weeks on and 2 weeks off, until the fusion gene expression is negative. Maintenance therapy: RIF and ATRA 2 weeks on and 2 weeks off for a total of 6 courses.
Following appropriate nasal local anesthetic, the channeled laryngoscope was inserted through the nose. The 6-0 monofilament was pressed against the posterior nasopharyngeal wall and swiftly removed to establish a perceptual strength of "1", as an internal anchor. The lateral pyriform sinus (LPS) was presented with the planned stimulus, followed by the aryepiglottic fold (AEF) and the false vocal folds (FVF). Participants were instructed to raise their hand when the stimulus was detected, and then were asked by the study team to report a perceptual strength "score," in comparison to the nasopharyngeal anchor strength of 1. LAR response was recorded by the study team. A negative response was defined as a lack of LAR to two appropriate stimuli. The LPS and AEF were tested in order of increasing stimulus: 6-0, 5-0, 4.5-0 and 4-0 monofilaments. The false vocal folds (FVF) were tested last. Testing of FVF terminated after the first observed LAR.
Patients will complete a 20-week supervised, progressive rehabilitation protocol directed by physical therapists at 1 of 3 participating clinics. While the specific rehabilitation exercises and techniques used for a given patient may vary depending on clinician preference/experience and patient responsiveness and progress, the general rehabilitation protocol will be standardized and follow current best practices emphasizing restoration of early weight bearing, range of motion, quadriceps function, balance, and neuromuscular control consistent with the Multicenter Orthopaedics Outcomes Network (MOON) rehabilitation protocol.
Placebo consists of 0.9% normal saline. Each injection will be 0.2mL, administered with a 25 gauge needle subcutaneously into the affected area. The marked area will have subcutaneous injections (maximum of 80) each separated from the surrounding ones by a radius of 1 cm.