anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Approximately 20% of breast cancer cases are attributed to increased family risk, yet variation in BRCA1/2 can only explain 20%-25% of cases. Historically, only single gene or single variant testing were common in at-risk family members, and further sequencing studies were rarely offered after negative results. In this study, we applied an efficient and inexpensive targeted sequencing approach to provide molecular diagnoses in 245 human samples representing 134 BRCA mutation-negative (BRCAX) hereditary breast and ovarian cancer (HBOC) families recruited from 1973 to 2019 by Dr. Henry Lynch. Sequencing identified 391 variants, which were functionally annotated and ranked based on their predicted clinical impact. Known pathogenic CHEK2 breast cancer variants were identified in five BRCAX families in this study. While BRCAX was an inclusion criterion for this study, we still identified a pathogenic BRCA2 variant (p.Met192ValfsTer13) in one family. A portion of BRCAX families could be explained by other hereditary cancer syndromes that increase HBOC risk: Li-Fraumeni syndrome (gene: TP53) and Lynch syndrome (gene: MSH6). Interestingly, many families carried additional variants of undetermined significance (VOUSs) that may further modify phenotypes of syndromic family members. Ten families carried more than one potential VOUS, suggesting the presence of complex multi-variant families. Overall, nine BRCAX HBOC families in our study may be explained by known likely pathogenic/pathogenic variants, and six families carried potential VOUSs, which require further functional testing. To address this, we developed a functional assay where we successfully re-classified one family's PMS2 VOUS as benign.
Sudden unexpected postnatal collapse (SUPC) is a sudden collapse of the clinical conditions of a full-term or near-term newborn, within the first 7 days of life, that requires resuscitation with positive ventilation and who either dies, has hypoxic-ischemic encephalopathy, or requires intensive care. The incidence of SUPC is very low, and most often presents a negative prognosis. The BUB1B gene is a mitotic checkpoint of serine/threonine kinase B that encodes a protein crucial for maintaining the correct number of chromosomes during cell division. Mutations in the BUB1B gene are linked to mosaic variegated aneuploidy syndrome 1 (MVA1), a rare autosomal recessive disorder characterized by diffuse mosaic aneuploidies involving several chromosomes and tissues. This paper discusses a case of a newborn who had a spontaneous delivery. After 2 h and 10 min, the infant showed generalized hypotonia and cyanosis, and his doctors performed orotracheal intubation, cardiac massage, pharmacological hemodynamic therapy, mechanical ventilation, antibiotic therapy, and hypothermic treatment. The newborn was discharged after 5 months with the diagnosis of hypoxic-ischemic encephalopathy. Suspecting an SUPC, a complete genetic analysis was performed demonstrating a compound heterozygous mutations in the BUB1B gene. The newborn died at 6 months of life, 1 month after discharge. A complete autopsy was performed, determining that the cause of death was due to sepsis starting from a brocopneumonic process, with outcomes of hypoxic-ischemic encephalopathy (HIE). In this scenario, it is not possible to demonstrate the causal effect of this mutation, considering that it could play a causal or concausal role in the onset of SUPC. Further research based on multicenter studies, as well as on animal models, could be very useful to clarify the pathological effect of this mutation.
Which domain of life evaluation is more important? Using a large-scale public sample of 1888 adults from the United States (880 males, 1008 females; Mage = 53.28), we addressed this question by comparing the predictive strength of six domains of life evaluations on overall life evaluation as well as biomarkers of inflammation. Specifically, we examined individuals' self-rated evaluations of the domains of social belonging, romantic relationships, work, subjective social status, self-esteem and finances, and we examined biological inflammation using an index of five biomarkers of inflammation: interleukin-6, fibrinogen, C-reactive protein, E-selectin and intercellular adhesion molecule 1. Adjusting for demographic variability, romantic evaluation, work evaluation, self-esteem and financial evaluation were equally and uniquely predictive of overall life evaluation. Social belonging remained predictive but was relatively weaker in magnitude, while subjective social status was no longer a significant predictor. Conversely, only financial evaluation was significantly linked to reduced biomarkers of inflammation. The findings suggest that depending on domain-specificity and whether well-being is assessed via subjective or objective indicators, links between life evaluations and well-being may show substantial nuance. In particular, financial evaluation appears to have unique links to biomarkers of inflammation even after accounting for other domains of life evaluations.
Good-quality embryos are critical for the success of in vitro fertilization (IVF). But, to date, there is no report of the effect of different diameters denuding pipette on the embryos quality. To investigate the effect of denuding pipette in IVF outcomes, we plan to recruit women undergoing IVF treatment cycles and classified them into two groups according to the different diameters. The participants were divided into two group. Odd-numbered days the zygotes were degranulated with the 140 microns needles. Even-numbered days the zygotes were degranulated with the 150 microns needles. Consequently, the rate of fertilization, zygotes cleaved, top quality embryos on D3, and blastocysts obtained were recorded.
The application relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing abiraterone acetate, and a preparation method and application thereof. The pharmaceutical composition comprises: active ingredients: abiraterone acetate; auxiliary materials: at least one oil phase, at least one emulsifier, and at least one co-emulsifier. The pharmaceutical composition provided by the application spontaneously disperses under gastrointestinal peristalsis when meeting gastrointestinal fluids after being orally taken to form O/W type nanoemulsion. The formed nanoemulsion has small particle size, increases the penetrability of intestinal epithelial cells, and can remarkably improve the bioavailability of the medicament. Compared with microemulsion, the self-emulsifying solution has higher stability and can meet the requirement of long-term storage. The medicine composition of the application has stable content. Compared with the original grinding agent Zytiga, the difference between before meal and after meal is obviously reduced; the pharmaceutical composition can be further prepared into capsules, and the capsules are stable in property.
The production of the high titer immunoglobulin preparation can be proceeded through the following steps implemented in sequence. The plasma is separated from a subsection of a plasma bank, thus at least one industrial use fraction basically contained with the polyclonal immunoglobulin G is separated to acquire at least one residual fraction. A protein solution is prepared from the residual fraction obtained from the last step or the protein component contained in the sub-fraction of the residual fraction. At least one fixed ligand of a ligand type is used for the implementation of at least one treatment of affinity chromatography for the generated protein solution, thus the specific plasma protein is combined with the ligand and the combined plasma protein is eliminated. The combination is used as an active ingredient to convert to the high titer immunoglobulin preparation. Such obtained immunoglobulin can be processed to a product with excellent IV tolerance and storage stability. In the approach for the preparing of the valuable immunoglobulin preparation, the human plasma fraction abandoned in the conventional separation method of the industrial plasma subsection is utilized.
Each treatment consists of 60 trains, each lasting 3 sec and interleaved with a 15 sec delay. The entire treatment is delivered over 20 min. The treatment goes for 5 days/week and for a total of 3 weeks.
Despite treatment with levothyroxine, hypothyroidism and autoimmune thyroiditis (AIT) may be associated with reduced quality of life (QoL), an enigmatic condition referred to as "syndrome T". Peripheral neuropathy, described in untreated thyroid disease, could be a contributing mechanism. We analysed autonomic and somatosensory function in 29 patients with AIT and treated hypothyroidism and 27 healthy volunteers. They underwent heart rate variability (HRV) analysis and quantitative sensory testing (n = 28), comprising 13 parameters of small and large nerve fibre function and pain thresholds. Autonomic cardiovascular function was assessed in rest, deep respiration and orthostasis. Additionally, biomarkers for autoimmunity and thyroid function were measured. Anxiety, depression and QoL were assessed using validated questionnaires. 36% of the patients showed at least one sign of somatosensory small or large fibre dysfunction. 57% presented with mild hyperalgesia to at least one stimulus. Several markers of autonomic function and some detection thresholds were related to the antibody titres. Anxiety, depression scores and QoL correlated to antibody titres and HRV measures. Autonomic and somatosensory dysfunction indicate that in treated hypothyroidism and AIT a subgroup of patients suffers from neuropathic symptoms leading to impaired QoL. Additionally, mild hyperalgesia as a possible sensitisation phenomenon should be considered a target for symptomatic treatment.
Patients with a major depressive episode treated with antidepressants. Patients will be investigated (i) prior to treatment, (ii) after 10 days of treatment, (iii) after 4 weeks of treatment, and (iv) after 6 months.
PURPOSE:The titled remover, containing gamma-valerolactone alone or further a mixture thereof with gamma-nonalactone or/and gamma-undecalactone as a main agent and having properties of not damaging fingertips or nails. CONSTITUTION:An enamel remover of nails obtained by using gamma-valerolactone (3-methylbutyrolactone) alone or incorporating the gamma-valerolactone with gamma- nonalactone or/and gamma-undecalactone at an optional ratio to give a main agent. The above-mentioned compounds have little side effects in spite of strong solvency. When an alcohol solution of hydroxypropyl cellulose and an ester, e.g. diethyl phthalate, are added, the remover becomes a viscous jelly form, which can be filled in a tube. Squalane, etc., may be further added to reduce the irritation and protect the skin of fingers.
This observational study is intended to answer the question, if the colon hydrotherapy (colonic irrigation with the "Colon Hydromat") works in real-life practice.

Colonic irrigation is regarded as a substitute for standard oral colonic purgative solutions for colonoscopy preparation. The advantage of colonic irrigation is that there is no unpleasant taste, it avoids the discomfort of diarrheic episode and there is no need to drink a large volume of water or fluids. The patient will receive the bowel irrigation with the "Colon Hydromat" directly before colonoscopy, at the same day. Aim of this study is to confirm performance (effectiveness), in terms of an adequate bowel preparation and safety of the "Colon-Hydromat", as alternative bowel cleansing device prior to colonoscopy. The primary performance (effectiveness) endpoint for this study is the colonic cleanliness, defined as overall quality of bowel cleansing as measured by the Boston Bowel Preparation Scale (BBPS). The primary safety endpoints for this study are adverse device events (ADE) and serious adverse device effects (SADE), product and procedure related.
Endothelial cells are a crucial component of the vessel-tissue wall and exert an important role in atherosclerosis (AS). To explore the role of Orientin in AS, human vascular endothelial cells (HUVECs) were induced by oxidized low-density lipoprotein (ox-LDL) to simulate the vascular endothelial injury during AS. Cell viability was detected by CCK-8 assay. Oxidative stress and inflammation related markers were measured using kits, RT-qPCR or western blot. Besides, cell apoptosis was assessed with TUNEL staining and cell autophagy was evaluated by LC3 immunofluorescent staining. Additionally, western blot was utilized to evaluate the expression of Sestrin 1 (SESN1) and proteins in AMPK/mTOR signaling. Afterwards, SESN1 was silenced to determine the expression of autophagy-related proteins. The further application of autophagy inhibitor 3-methyladenine (3-MA) was used to clarify the regulatory mechanism of Orientin on autophagy. Results showed that the decreased viability of HUVECs caused by ox-LDL induction was elevated by Orientin. Oxidative stress and inflammation were also attenuated after Orientin addition in HUVECs under ox-LDL condition. Moreover, Orientin suppressed apoptosis and induced autophagy of HUVECs stimulated by ox-LDL, accompanied by enhanced level of phospho (p)-AMPK and declined level of p-mTOR. Interestingly, SESN1 level was elevated by Orientin, and SESN1 depletion alleviated autophagy and reduced p-AMPK expression but enhanced p-mTOR expression. The further experiments indicated that SESN1 silencing or 3-MA addition reversed the inhibitory effects of Orientin on the oxidative stress, inflammation and apoptosis of HUVECs. Collectively, Orientin could induce autophagy by activating SESN1 expression, thereby regulating AMPK/mTOR signaling in ox-LDL-induced HUVECs.
An integrated system for delivering weight loss guidelines and activity tracking in a mobile format. The integrated system includes a weight loss program hosted on a mobile device. The weight loss program includes an energy intake prescription to direct participants to approach a target weight according to a weight loss predictive model visually depicted in a first application window. The mobile device may be paired with a weight sensor to provide weight updates on a regular basis. The mobile device may also be paired with a heat consumption measurement device (e.g., a step counter) to display activity levels for comparison with recommended activity targets in a second application window. The weight loss program extends a number of phases that are configured to help individuals gradually achieve sustainable weight loss while increasing daily activity levels during the duration of the program.
FIELD: medicine, cosmetic hygienic massage. SUBSTANCE: method deals with cosmetic hygienic massage with simultaneous cutaneous application of curative hygienic composition. Method deals with complex cutaneous impact at optimal combination of complex massage of skin and muscles at correct concentration of bioactive substances of cutaneously applied curative hygienic composition formulated in proportional dosage, wt-%: vitamins, 20-35; adaptogens, 4-6; phytohormones, 3-6; biostimulators, 8-12; liposomized base, the balance. At optimal regulation of massage seances curative hygienic composition of mentioned formula is applied at the following proportion, wt-%: for neck and face, 8-12; for body including limbs, the balance, in the quantity of 80-120 ml. EFFECT: higher efficiency of cosmetic massage due to exclusion of overdose of curative hygienic composition applied, overloading of facial skin, application of strong medicinal preparations and also due to preventing skin destruction and skin aging at prolonged massage course. 1 cl, 6 cl, 1 tbl
Participants will be analyzed for ADHD who are new users of atomoxetine monotherapy. Analysis of data will be performed between 1 January 2001 to 30 September 2018.
Inequalities in health behaviors are thought to contribute to inequalities in hypertension. This study examined the extent to which modifiable mediating factors explain income inequalities in hypertension. This repeated cross-sectional study used data from National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) from 2009 to 2015. Those aged between 40 and 74 were enrollees in the Specific Health Checkups. Hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90, or the use of antihypertensive medication. The mediating effects of exercise, obesity, smoking, and alcohol drinking on the association between income, as an indicator of SES, and hypertension were determined by the Karlson-Holm-Breen (KHB) method. The mean age of the 68,684,025 men and 59,118,221 women was 54.7 (SD = 9.6) and 56.7 (SD = 10.0) years, respectively. Prevalence of hypertension was higher in the lowest income group (48.6% for men, 40.2% for women) than in the highest income group (33.3% for men, 21.5% for women). Inequalities tended to increase over time. Inequalities were larger among those who did not use antihypertensive medication. Modifiable risks explained 10.6% of the association between income and hypertension for men and 15.1% for women. In men, drinking and obesity explained 8.8% and 5.5% of the inequalities in hypertension, respectively. In women, obesity explained 18.8%. Exercise increased the proportion mediated over time. Smoking explained 5.5% among women taking antihypertensive medication. There were health inequalities in hypertension among Japanese adults, and the modifiable risk factors partially explained the inequalities.
Infantile hemangioma (IH) is the most frequent vascular tumor of infancy with unclear pathogenesis; disordered angiogenesis is considered to be involved in its formation. Apolipoprotein A-I binding protein (AIBP)-also known as NAXE (NAD [P]HX epimerase)-a regulator of cholesterol metabolism, plays a critical role in the pathological angiogenesis of mammals. In this study, we found that AIBP had much lower expression levels in both tissues from patients with IH and hemangioma endothelial cells (HemECs) than in adjacent normal tissues and human dermal vascular endothelial cells, respectively. Knockout of NAXE by CRISPR-Cas9 in HemECs enhanced tube formation and migration, and NAXE overexpression impaired tube formation and migration of HemECs. Interestingly, AIBP suppressed the proliferation of HemECs in hypoxia. We then found that reduced expression of AIBP correlated with increased hypoxia-inducible factor 1α levels in tissues from patients with IH and HemECs. Further mechanistic investigation demonstrated that AIBP disrupted hypoxia-inducible factor 1α signaling through cholesterol metabolism under hypoxia. Notably, AIBP significantly inhibited the development of IH in immunodeficient mice. Furthermore, using the validated mouse endothelial cell (ie, EOMA cells) and Naxe-/- mouse models, we demonstrated that both endogenous AIBP from tumors and AIBP in the tumor microenvironment limit the formation of hemangioma. These findings suggested that AIBP was a player in the pathogenesis of IH and could be a potential pharmacological target for treating IH.
Since transcription factor Forkhead Box P3 (FoxP3) was identified as a specific regulatory T cell (Treg) marker, researchers have scrutinized its value as a potential novel therapeutic target or a prognostic factor in various types of cancer with inconsistent results. The present analysis was performed to assess the influence of Treg FoxP3 expression on the prognosis of primary melanoma and to evaluate the correlations with various clinicopathological prognostic factors. We analyzed all eligible patients with stage pT3 primary malignant melanomas treated in a tertiary cancer center. Immunohistochemical staining for Treg FoxP3 expression was performed on retrospectively identified paraffin blocks and subsequently correlated with the outcomes of the patients. A total of 81% of the patients presented a positive Treg FoxP3 expression, being correlated with a higher risk of lymph node metastasis, tumor relapse, and death. Moreover, positive expression was statistically associated with a shorter OS. The tumor relapse rate was estimated at 36.7%. A positive expression of Treg FoxP3 and lymph node metastasis were associated with a higher risk of death based on multivariate analysis. Treg FoxP3 expression may be used as an independent prognostic factor in patients with malignant melanoma to evaluate tumor progression and survival.
PURPOSE: To obtain a synergistic composition for treating periodontal disease comprising an antioxidant and an arylpropionic non-steroidal antiinflammatory drug, capable of inhibiting the formation of prostaglandin and preventing and obstructing tissue-destruction in periodontal disease. CONSTITUTION: This synergistic composition for treating periodontal disease includes (A) an antioxidant, e.g. α-tocopherol, ascorbic acid or its hydrochloride, and precursors thereof containing vitamin A or α-carotene, (B) an arylpropionic non-steroidal antiinflammatory drug, e.g. ibuprofen, ketoprofen, flurbiprofen and naproxen, in proportions of 0.01-10wt.%, preferably 0.03-2.0wt.% component A and 0.01-10wt.%, preferably 0.01-2wt.% component B. The composition is preferably formulated with a polymer having adherence to the mucosa (e.g. karaya gum, CMC-Na or a copolymer composed of a lower alkyl vinyl ether and maleic anhydride) and directly administrated to the gingival tissue.
ARX788 will be administered every 3 weeks (Q3W) or every 4 weeks (Q4W) via intravenous (IV) infusion. Patients will be enrolled into escalating dose levels during Dose Escalation period.
The risk of myopathy, including rhabdomyolysis, with simvastatin and lovastatin monotherapy is dose related. Lomitapide approximately doubles the exposure of simvastatin; therefore, the recommended dose of simvastatin should be reduced by 50% when initiating JUXTAPID [see Clinical Pharmacology (12.3)]. While taking JUXTAPID, limit simvastatin dosage to 20 mg daily (or 40 mg daily for patients who have previously tolerated simvastatin 80 mg daily for at least one year without evidence of muscle toxicity). Refer to the simvastatin prescribing information for simvastatin dosing recommendations.

Interaction between lovastatin and lomitapide has not been studied. However, the metabolizing enzymes and transporters responsible for the disposition of lovastatin and simvastatin are similar, suggesting that JUXTAPID may increase the exposure of lovastatin; therefore, reducing the dose of lovastatin should be considered when initiating JUXTAPID.
In this group, patients will have their cholecystectomy deferred from their initial hospitalization for various reasons. They will be seen again 3 months after leaving hospital. They will or will not have been cholecystectomized during this interval. Their mode of feeding as well as biliary events will be studied.
The natural aging process involves several body changes that can affect to the mobility of subjects. Among them, those that affect the joints may have the greatest impact on mobility. With age, there is a progressive loss of the cartilage that covers the joints, as well as the synovial fluid, which in turn increases the stiffness of the ligaments and tendons that allow joint mobility, which implies a reduction in muscle tone and bone strength. This joint degeneration produces pain and discomfort, which leads to stiffness and restriction of movement. Therefore, and as a consequence of this loss of mobility, subjects decrease their physical performance, which can affect their mood and vitality. All of these may lead to a loss of quality of life and to an increase of the risk of future adverse health events, such as disability, institutionalization, hospitalization and the need for home medical care.

For all these reasons, and considering the increase in the ageing population worldwide, it seems relevant to develop new strategies to improve joint mobility, physical performance and vitality that are safe for the consumer, affordable and not associated with undesirable side effects. In this regard, natural plant extracts have been widely used as a traditional remedy to reduce joint pain, reduce fatigue and improve mood and physical performance.