anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE OF REVIEW: Increasing uptake of gender affirming surgery has allowed for a wider breadth of publication examining complications associated with vaginoplasty. This review aims to provide a comprehensive overview of complications associated with vaginoplasty procedures, focusing on intraoperative, early postoperative, and delayed postoperative complications across different surgical techniques.
RECENT FINDINGS: Intraoperative complications such as bleeding, injury of the rectum, urethra and prostate, and intra-abdominal injury are discussed, with insights into their incidence rates and management strategies. Early postoperative complications, including wound dehiscence, infection, and voiding dysfunction, are highlighted alongside their respective treatment approaches. Moreover, delayed postoperative complications such as neovaginal stenosis, vaginal depth reduction, vaginal prolapse, rectovaginal fistula, and urinary tract fistulas are assessed, with a focus on their etiology, incidence rates, and management options.
SUMMARY: Vaginoplasty complications range from minor wound issues to severe functional problems, necessitating a nuanced understanding of their management. Patient counseling, surgical approach, and postoperative care optimization emerge as crucial strategies in mitigating the impact of complications. Standardizing complication reporting and further research are emphasized to develop evidence-based strategies for complication prevention and management in vaginoplasty procedures.
Acrochordon, also called soft fibroma, skin tag or fibroepithelial polyp, is a common cutaneous disorder characterized by a polypoid growth composed of fibroblasts in a loose collagenous stroma, sometimes with proliferation of blood vessels. They appear as soft, skin-colored or light brownish skin tumors. Three types of lesions may occur, (1) multiple small, furrowed papules, especially on the neck and in the axillae, (2) single or multiple filiform smooth growths in various locations, and (3) solitary bag-like pedunculated growth, seen most commonly on the lower trunk. Most regard them as a sign of cutaneous aging.

The presence of human papillomaviruses (HPVs), especially the mucosal types, has been demonstrated in acrochordon. Our previous experience on HPV typing of skin tags also confirms this finding. Though HPV is a ubiquitous virus, the presence of mucosal type HPV in non-mucosal sites is exceptional. This investigation is trying to correlate the clinicopathological and HPV molecular typing of acrochordons. A better understanding of acrochordon and its relation to HPV infection may improve the ability to prevent and treat.
<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for external use excellent in bleaching and/or antiaging effect.  <P>SOLUTION: This skin care preparation for external use comprises an extract of Tithonia diversifolia (Hemsl) A. Gray as an active ingredient, particularly as a bleaching agent or an antioxidant. The skin care preparation for external use can be supplied to various kinds of applications, e.g. cosmetics, quasi-drugs and external medicines. Since the skin care preparation for external use is excellent in bleaching effect and/or antiaging effect, the preparation is particularly useful as a cosmetic.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Arm 2: 40 patients will be assigned to the Ergocalciferol treatment group. Patients will be randomized once they meet inclusion and exclusion criteria. If patients are not on any vitamin D treatment when enrolled, they will have 2 screening visits before randomization. Screening visits will consist of a physical exam and lab tests to measure Vitamin D, calcium, iPTH, and safety profile. Patients on vitamin D treatment prior to study will have a minimum 4 week washout period before screening tests. Patients' Lean Body Mass and Aortic Blood Pressure and pulse wave velocity will be measured before dosing. Cardiovascular markers will be checked throughout the study. Patients will be monitored monthly after starting study treatment. Total treatment period: 4 months.
BACKGROUND: Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor that usually occurs in the proximal extremities and trunk. The purpose of this systematic review was to assess patient demographics, treatment approach, and outcomes for patients with LGFMS of the distal upper extremity.
METHODS: We performed a literature review of case reports and patient reports of LGFMS using Medical Literature Analysis and Retrieval System Online (MEDLINE) and PubMed. Inclusion criteria included case reports and case series of patients with LGFMS of the distal upper extremity. Animal studies, comments, and non-English publications were excluded. Data on available patient demographics, treatment regimen, recurrence, and metastasis were collected.
RESULTS: A total of 365 publications were reviewed. After applying the inclusion and exclusion criteria, 19 articles were included. There were 24 unique patients with LGFMS of the distal upper extremity. The median age was 32 years, and most patients were treated with a surgical excision. Of the 15 reported outcomes, 4 patients had local recurrences, and no patient had metastases or died due to the tumor.
CONCLUSIONS: Although LGFMS of the distal upper extremity is less common, it is critical for surgeons to consider it as a differential. The current approach is a wide excision with negative margins, and chemotherapy or radiotherapy may not be necessary. We found decreased proportions of local recurrence and metastases in the distal upper extremity compared with other anatomical regions. We recommend that surgeons follow up with their patients indefinitely given the slow mitotic rate of LGFMS.
PURPOSE: A composition for relieving hangover and a composition for treating alcoholic fatty liver containing a mixture crude drug formulation are provided to promote alcohol metabolism in the body and to prevent or treat alcoholic liver diseases. CONSTITUTION: A composition for preventing or relieving hangover contains Pharbitis seeds, Pueraria lobata Ohwi, Citrus unshiu Markovich, Crataegus pinnatifida Bunge for. Pinnatifida, Alpinia katsumadai, Poria cocos[Schw.] Wolf, Alpinia officinarum, Ammomum xanthioides Wallich, Atractylodes lancea De Candolle, Zingiber cassumunar Roxb., Zizyphus jujuba MILL, Hovenia dulis Thunb, Magnolia officinalis Rehd. et Wils., or Glycyrrhiza Radix as an active ingredient. The composition also contains 0.01-10 wt% of vitamin B1, B2, B6, B12, or C, pantothenic acid, nicotinic acid amide, folic acid, biotin, zinc, iron, calcium, or magnesium. A pharmaceutical composition for preventing or treating alcoholic fatty liver contains Pharbitidis Semen, Puerariae Radix, Aurantii nobilis Pericarpium, Alpiniae katsumadaii Semen, Tuckahoe, Alpinia officinarum, Atractylodis Rhizoma, ginger, jujube, sesame, Magnoliae Cortex and Glycyrrhizae radix as an active ingredient. [Reference numerals] (AA) Ethanol concentration in serum; (BB) Groups
Participants in the control group will receive treatment as usual. This consists of scheduled appointments in the hospital-based nurse-led botulinum toxin clinic. The frequency with which these appointments takes place are based on clinical judgement, but tend to range between every 6 weeks to every 4 months.
Parkinson's Disease (PD) is primarily known and characterized by motor symptoms such as tremor, rigidity and bradykinesia. However, a significant number of non-motor symptoms also accompany the unfolding of this disease. In fact, hallucinations are experienced by approximately 60% of the patients. The most common and amongst one of the earliest hallucinations in Parkinson's Disease, is the Presence Hallucination (PH), i.e., the strange sensation of perceiving someone behind when no one is actually there. In the present study the researchers aim at investigating the behavioural and neural mechanisms underlying symptomatic PH in PD. To do so the researchers intend to induce the PH in a repeated and controlled manner in the MRI scanner, with an extensively verified paradigm which gives rise to this sensation by means of robotically-mediated sensorimotor stimulation. This setup has in fact been shown to trigger the occurrence of symptomatic PH in these patients. The possibility to induce PH while the patient is in the MRI will allow the researchers to investigate online the brain networks associated with it.

With analysis on the fine brain connectivity changes during PH-induction, the investigators intend to pinpoint the exact mechanism behind the appearance of this hallucination in these patients, in a similar fashion to previous work with the PH-induction in healthy individuals.
The MTS2 Study is funded for through a five-year K23 NIH training grant (appendix) awarded to Dr. James Davis, the Principal Investigator on this protocol. The study enrollment goal is N=240 adult smokers randomized to study treatments. Based on prior recruitment numbers, it is expected that roughly 50% (120) will choose to be in an intensive intervention and 50% (120) will choose to be in the non-intensive intervention. Participants who choose to be in an intensive intervention will be randomized to either MTS (n = 60) or ITS (n=60). MTS is a smoking cessation intervention that provides 8 mindfulness classes over a 6-week period. ITS will provide participants will access to the Freedom From Smoking Online Premium Program (at no cost) plus 8 smoking cessation classes over a 6-week period. Participants who choose to be in a non-intensive intervention (n=120) will receive a phone-based intervention through the Wisconsin Tobacco Quit Line. At the Orientation Meeting, participants who decide to enter the study will be allowed to choose whether they enter an intensive or the non-intensive intervention. Intensive intervention participants will attend an additional meeting called the Introductory Meeting where they are will undergo randomization into either the MTS or ITS. The Introductory Meeting will also provide instruction on the use of nicotine patches, smoking calendars and provide intervention materials. The study employs 3 study assessment visits. Study Visit 1 follows the Orientation Meeting, Study Visit 2 is 4-weeks post-quit, Study Visit 3 is 24-weeks post-quit. All participants will receive 2 weeks of free nicotine patches and $30 for attending each of the two post-quit study visits.

The total time for the study including recruitment, intervention and participant follow-up for N = 240 will be three years. The study will recruit subjects from the Dane county region through the University of Wisconsin School of Medicine and Public Health Center for Tobacco Research and Intervention (UW-CRTI). Recruitment will take place through flyers, television, newspaper and radio advertisements.

The principal hypothesis for the study is that MTS compared to ITS will show significantly higher point prevalent Carbon Monoxide confirmed smoking abstinence rates at 4 and 24 weeks post quit. Secondary hypotheses is that study group compared to controls will show significant differences in questionnaire results that test distress, depression, anxiety, attentional control, mindfulness and quality of life and bio-physiological markers such as weight, breath holding and hair cortisol.
The present invention provides an MHC Class II antigen presentation enhancing hybrid polypeptide. The hybrid has an N-terminus comprising the mammalian Ii key peptide LMRKLPKPPKPVSKMR (SEQ ID NO:1) and modifications thereof which retain antigen enhancing activity, a C-terminus comprising an antigenic epitope in the form of a polypeptide or peptidomimetic structure  which binds to the antigenic peptide bending site of an MHC Class II molecule, and an intervening chemical structure covalently linking the N-terminal and C-terminal components. Methods for identifying a molecule which functions within the context of an MHC class II antigen presentation enhancing hybrid in an equivalent fashion as the Ii key peptide are also described. The present invention also provides a metod for enhancing presentation of an MHC Class II restricted antigenic epitope to a T cell. Both in vivo and ex vivo methods are provided. A method for identifying a compound which inhibits MHC Class II antigen presentation is also provided.
Pregnancy appears to pose a further barrier to exercise, as women remain inactive or cease to exercise all together. Yet, regular physical activity during pregnancy in healthy women has been shown to be safe and positively associated with physical and psychological health benefits. To date interventions to promote physical activity have not targeted pregnant women. We are proposing to pilot the first study to evaluate a theory-derived intervention designed to promote physical activity during pregnancy. We anticipate that pregnant women assigned to the motivationally-tailored exercise intervention will show a significant increase in physical activity from baseline at the post-treatment follow-up (32 weeks gestation). We expect that the motivationally-tailored intervention will positively influence physical and mental health status during pregnancy.
PROBLEM TO BE SOLVED: To provide a product that is effective for health promotion, assistance of plant growth and the freshness retention for perishable foods and flower arrangements by using a cell bodies-activating agent originating from natural materials. SOLUTION: A chitosan solution is added to a trehalose solution and they are stirred, as a leaf extract from a kind of bamboo and a tourmaline solution are added to the mixture. The weight ratios of individual components are 1.6 chitosan, 1.6 bamboo.leaf extract and 2.7 tourmaline per 1 trehalose. In the case where a naturally occurring softening agent is added to the agent, 1/4 amount of trehalose is admixed to the softening agent. Then, natural water is added to adjust the viscosity whereby the objective cell-activating agent. Woven fabrics or nonwoven fabrics are coated or impregnated with the resultant activating agent whereby the sheet products for health enhancement are produced.  Since these sheet products emit the wave motions that can increase the cell activity, the balance between the blood circulation, the autonomic nerves and the metabolite system is increased only by sitting on the sheet, for example, lying on the bed, as the sheet is placed under the mat or by sitting on a chair, as the sheet is hung down on the seat back of the chair. In addition, the sheet can manifest the growth enhancement effect of plants and the freshness retention effect for the perishable foods.
Recent studies have shown that a pro-inflammatory diet and dysbiosis, especially a high level of trimethylamine-N-oxide (TMAO), are associated with various adverse health conditions. Cardiovascular diseases and pancreatic diseases are two major morbidities in the modern world. Through this narrative review, we aimed to summarize the association between a pro-inflammatory diet, gut microbiota, and cardiovascular and pancreatic diseases, along with their underlying mechanisms. Our review revealed that TMAO is associated with the development of cardiovascular diseases by promoting platelet aggregation, atherosclerotic plaque formation, and vascular inflammation. TMAO is also associated with the development of acute pancreatitis. The pro-inflammatory diet is associated with an increased risk of pancreatic cancer and cardiovascular diseases through mechanisms that include increasing TMAO levels, activating the lipopolysaccharides cascade, and the direct pro-inflammatory effect of certain nutrients. Meanwhile, an anti-inflammatory diet decreases the risk of cardiovascular diseases and pancreatic cancer.
The invention provides a traditional Chinese medicine composition for treating diabetic peripheral neuropathy and a preparation method thereof. In the raw materials for preparing the traditional Chinese medicine composition, the astragalus and the red ginseng tonify qi and strengthen spleen, the rehmannia root and the medlar nourish yin and blood, the angelica and the blood nourish collaterals, and the astragalus, the red ginseng, the rehmannia root, the medlar and the angelica have the functions of tonifying qi and nourishing yin and dredging collaterals after being used together. The red sage root, the red peony root and the achyranthes root can promote blood circulation and remove blood stasis so as to generate new blood; caulis Spatholobi, caulis Trachelospermi, radix Clematidis, and ramulus Cinnamomi are used to remove meridian obstruction and relieve pain. The rhizoma ligustici wallichii is used for promoting qi and activating blood to prevent stasis; coptis root, rhizoma Coptidis clears heat and purges fire, clears stagnated heat produced by chronic diseases. Licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. The astragalus and cassia twig takes the effect of astragalus and cassia twig five-material decoction to tonify qi, promote blood circulation and remove meridian obstruction. The Chinese medicinal composition has effects of effectively reducing blood sugar, regulating blood lipid, improving microcirculation, improving high blood viscosity and platelet coagulation, and improving anoxia and ischemia of nerve; has the advantages of good treatment effect, short treatment course, low cost, simple preparation method and the like.
The medical plaster incorporates a lead layer which absorbs gamma or X-ray radiation. This lead layer is either smooth or with greater thicknesses is folded or laminated so that the plaster can conform to the body contours of the patient. On its packaging the plaster carries an indication of the absorption value of the clinically most important isotope. The plaster has at its base a wound-covering layer with adhesive zones, above which is the lead absorbing layer. There is an intermediate layer of cellular material, and an outer plastic covering. ADVANTAGE - To protect the ambiance of a patient being treated with a radio-isotope therapy.
The invention discloses an application of artepillin C in preparing drugs for preventing and treating radiation-induced damage. The research personnel of the invention discover that artepillin C can effectively increase a survival rate of HaCat cells after high radiation. The artepillin C can reduce the damage of skin after the radiographic exposure. The artepillin C can increase the content of white blood cell count of peripheral blood of mice after the radiographic exposure and the content of bone marrow cell DNA, and can increase a serum hemolysin level of the mice. The artepillin C can increase a thymus coefficient and spleen coefficient of the mice after the radiographic exposure. The artepillin C can increase a salivary gland index of the mice after the radiographic exposure and increase the content of sIgA in saliva.
PURPOSE:To provide a cataplasm made up of a substrate and an ointment having excellent followability even for the sites with complicate mobility such as the scruff of the neck and the flank, using, as the substrate, a stretchable one with each specified modulus and rigidity determined by the JIS general fabric test. CONSTITUTION:The objective cataplasm to be used as a plaster, etc., made up of a substrate and an ointment. The substrate is a stretchable one with a 50% modulus 0.1-2.0 (pref. 0.1-0.8)kg/5cm and a rigidity determined by the JIS general fabric test of 0.200-0.650 (pref. 0.250-0.450) in terms of drape factor. The present cataplasm is excellent in followability even for human skin of vigorously mobile or complicated sites such as the joints, the scruff of the neck and the flank, therefore, being resistant to debonding off the skin, high in adherability, and having high therapeutic effect with the good cooling effect of the ointment and the high absorbability for active ingredients.
Patients receive onvansertib PO QD on days 1-10 in the absence of disease progression or unacceptable toxicity. Within 12-24 hours, patients undergo biopsy or surgery as clinically appropriate per institutional standards for management of patient's disease.
A system and method for processing patient data permits physicians and other medical staff personnel to record, accurately and precisely, historical patient care information. An objective measure of a physician's rendered level of care, as described by a clinical status code, is automatically generated. Data elements used in the determination of the generated clinical status code include a level of history of the patient, a level of examination of the patient, a decision-making process of the physician treating the patient, and a "time influence factor." The quantity and quality of care information for a particular patient is enhanced allowing future care decisions for that patient to be based on a more complete medical history. Enhanced care information can be used in outcome studies to track the efficacy of specific treatment protocols. Archiving of patient information is done in a manner which allows reconstruction of the qualitative aspects of provided medical services. The medical care data can be recorded, saved, and transferred from a portable system to a larger stationary information or database system. Considerable physician and staff time are saved and precision and accuracy are significantly enhanced, by generating these clinical status codes automatically (at the point of service by the care-provider without any intermediary steps) from information recorded simultaneously with the provision of services.