anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A quadrivalent human papilloma virus (HPV) vaccine called Gardasil had recently (at start of study) been developed and approved by the FDA for the prevention of cervical HPV infection and cervical cancer, which is associated with infection from this virus. It is unknown whether the same vaccine could also be of benefit in treating anogenital warts, which are caused by the same virus. This is an important and clinically relevant question which needs to be answered. Anal warts have a high prevalence and recurrence and usually require extended lengths of treatment and follow-up, especially in the HIV population. At times, treatment of anal warts requires multiple surgeries to excise them if the burden of disease is high. Therefore, this disease represents a significant expense to patients and the health care system.

Further, the HPV virus that causes anal warts has been associated with anal cancer and with its preliminary lesion known as anal intraepithelial neoplasia (AIN). This study touches on two important, relevant and costly healthcare issues: finding a better treatment for the most common sexually transmitted disease in our country, and helping to prevent anal cancer, which is often a fatal disease.
The invention provides a spermatogenesis promoting decoction. The spermatogenesis promoting decoction has the functions of nourishing the kidney, replenishing essence and tonifying qi and blood and has excellent effects in treating deficiency of kidney essence and oligospermia caused by deficiency of qi and blood. A Chinese medicine composition is formed by combining the crude drugs of raspberry, semen cuscutae, wolfberry fruit, schisandra chinensis, semen plantaginis, Angelica sinensis, rehmannia glutinosa, red peony roots, dangshen, poria cocos, teasel roots, herba epimedii, liquorice and the like. The spermatogenesis promoting decoction has the functions of nourishing the kidney, replenishing essence and tonifying qi and blood for men and has the rapid curative effects in treating deficiency of kidney essence and oligospermia caused by deficiency of qi and blood. Natural Chinese medicine ingredients have no side effect on the body. In addition, the permatogenesis promoting decoction can nourish sperms and effectively increase the number of the sperms.
Mixed legacy and emerging per- and polyfluoroalkyl substances (PFASs) are commonly found in soil and dust; however, the potential toxicity of PFAS mixtures (mPFASs) in insects is unknown. Using 16S rRNA gene sequencing and transcriptome sequencing (RNA-Seq), we evaluated the adverse effects of mPFASs on silkworms, a typical lepidopteran insect. After exposure to mPFASs, the silkworm midgut was enriched with high levels of PFASs, which induced histopathological changes. The composition of the midgut microbiota was significantly affected by mPFAS exposure, and functional predictions revealed significant disruption of some metabolic pathways. RNA-seq analysis revealed that mPFASs significantly changed the transcription profiles. Functional enrichment analysis of the differentially expressed genes also revealed that biological processes related to metabolic pathways and the digestive system were significantly affected, similar to the results of the gut microbiota analysis, suggesting that mPFAS exposure had an adverse effect on the metabolic function of silkworms and may further affect their normal growth. Finally, the significant correlation between abundance changes in the gut microbiota and metabolism/digestion-related genes further highlighted the role of the gut microbiota in mPFAS-related processes affecting the metabolic functions of silkworms. To our knowledge, this study is the first to evaluate the toxic effects of mPFASs in insects and provide basic data for further PFAS toxicity investigations in insects and comprehensive ecological risk assessments of mPFASs.
BackgroundActive follow-up of chronic hepatitis C notifications to promote linkage to care is a promising strategy to support elimination.AimThis pilot study in Victoria, Australia, explored if the Department of Health could follow-up on hepatitis C cases through their diagnosing clinicians, to assess and support linkage to care and complete data missing from the notification.MethodsFor notifications received between 1 September 2021 and 31 March 2022 of unspecified hepatitis C cases (i.e. acquired > 24 months ago or of unknown duration), contact with diagnosing clinicians was attempted. Data were collected on risk exposures, clinical and demographic characteristics and follow-up care (i.e. HCV RNA test; referral or ascertainment of previous negative testing or treatment history). Reasons for unsuccessful doctor contact and gaps in care provision were investigated. Advice to clinicians on care and resources for clinical support were given on demand.ResultsOf 513 cases where information was sought, this was able to be obtained for 356 (69.4%). Reasons for unsuccessful contact included incomplete contact details or difficulties getting in touch across three attempts, particularly for hospital diagnoses. Among the 356 cases, 307 (86.2%) had received follow-up care. Patient-management resources were requested by 100 of 286 contacted diagnosing clinicians.ConclusionsMost doctors successfully contacted had provided follow-up care. Missing contact information and the time taken to reach clinicians significantly impeded the feasibility of the intervention. Enhancing system automation, such as integration of laboratory results, could improve completeness of notifications and support further linkage to care where needed.
Endodontic treatment was performed in posterior teeth with necrotic pulp and periapical periodontitis using a reciprocating single-file system (Reciproc). Local anesthesia was provided (2% Novocaine with 1:80,000 epinephrine), isolation with rubber dam and standard access cavity preparation was done.Using 2.5 % sodium hypochlorite, canal negotiation was done \& apical patency was achieved with #10 K-files in patency group after determining working length. Coronal flaring with # 2 and #3 Gates-Glidden drills was done. The canals were obturated with gutta-percha and epoxy resin sealer. The treatments were carried out in one-visit.
Glyburide tablets should be added gradually to the dosing regimen of patients who have not responded to the maximum dose of metformin monotherapy after four weeks (see Usual Starting Dose and Titration to Maintenance Dose). Refer to metformin package insert.

With concomitant glyburide and metformin therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. However, attempts should be made to identify the optimal dose of each drug needed to achieve this goal. With concomitant glyburide and metformin therapy, the risk of hypoglycemia associated with sulfonylurea therapy continues and may be increased. Appropriate precautions should be taken (see section). PRECAUTIONS
FIELD: satisfaction of vital human requirements.SUBSTANCE: present invention relates to a liquid milk enrichment composition for administration to infants or older children. Liquid composition of milk enriching agent contains lipid in amount exceeding 75 % of energy value, wherein the lipid contains medium chain triglycerides in amount of 25 to 40 wt. % of the total lipid content, arachidonic acid in amount of 0.2 to 2 wt. % of the total lipid content and docosahexaenoic acid in amount of 0.1 to 1.5 wt. % of total content of lipids. Liquid composition is used for enrichment of infant formula, human breast milk or milk for children from 1 year to 3 years. Liquid composition of milk enriching agent is used to increase growth of infant or child of older age and/or to increase energy consumption by baby or child of older age. Disclosed is a set of components comprising a main nutritional formula and said liquid milk enrichment composition. Also disclosed is a package containing said composition and representing a batcher with a single dose, a multi-dose dispenser or a pre-filled feeding device.EFFECT: invention provides feeding of infants or children of older age with adapted content of lipids and/or calories.16 cl, 1 ex
Treatment As Usual (TAU) augmented by a neutral topic writing condition. The neutral topic writing condition involves writing about an assigned topic during each of the five writing sessions. As opposed to writing about trauma, the specific focus of this condition is on writing for 30 minutes about topics related to their life without writing about emotions or opinions. Rather, they are asked to write about specific objects or events in detail, as accurately as possible, and with as much description as possible. All writing sessions begin with specific instructions from the therapist followed by 30 minutes of writing by the participant.
FIELD: medicine, pharmacology, pharmacy. SUBSTANCE: sedative drug has alpha-bromoisovaleric acid ethyl ester, phenobarbital, peppermint essential oil, marjoram essential oil prepared by reextraction of marjoram herb technical grade carbonic acid extract with 70% ethyl alcohol and 50% spirituous-aqueous mixture in the following ratio of components, g/100 g of agent: alpha-bromoisovaleric acid ethyl ester, 2.0; phenobarbital, 2.0; peppermint essential oil, 0.14; marjoram essential oil, 0.02 and 50% ethyl alcohol up to 100. Method of preparing marjoram essential oil for medicinal aims by its extraction from marjoram herb involves reextraction of marjoram herb technical grade carbonic acid extract with 70% ethanol. Suspended particles are removed and marjoram essential oil ethanol solution is obtained. Method can be used for preparing sedative drugs and marjoram essential oil prepared by proposed method shows antistress activity. EFFECT: improved method of preparing, improved quality of sedative agents. 3 cl, 2 tbl, 2 ex
A portable data-management system may be easily employed with multiple processing devices by eliminating the need to pre-install additional programs, agents, device drivers, or other software components on the hosts. A portable storage device contains software for a data-management application, which receives and processes test data from a meter that measures an analyte. The portable device may employ an interface protocol that makes the portable device immediately compatible with different operating systems and hardware configurations. Once the portable device is connected to the host, the data-management application can be automatically launched. The convenience and portability of a data-management system may be enhanced by integrating advanced data processing and display features with the portable device. The users may access some advanced presentations of health data without having to launch the data-management application on a separate host.
Male sexual organ disease, including: prostatitis, seminal vesiculitis, spermatitis, orchitis, epididymitis, prostatic hyperplasia, and prostatic cancer. Based on the principle that pain is not smooth and pain is not smooth, the Qianliexiao pill developed by the inventor is mainly used for softening hardness and resolving stagnation, promoting qi and activating blood, mainly used for detoxifying and diminishing inflammation and used for nourishing yin and blood and consolidating foundation. Firstly, the qi and blood can smoothly circulate, the qi and blood can not be deficient, and the qi can circulate along with the blood, so as to dredge the micro circulation in the prostate gland body, promote the therapeutic medicine to circulate through the blood and enter the deep layer in the prostate gland body, and enable the therapeutic medicine to kill the bacteria or viruses in the prostate gland body. The medicines in the formula are free from conflict, reasonable in matching and safe to take, and can achieve the effects of eliminating healthy energy, tonifying without remaining pathogenic factors and supplementing each other to form a delicate acting force, so that dampness, turbidity, stasis and toxicity accumulated in the prostate gland can be eliminated. Pathogenic toxin is not dispelled, and body is cold in yin. If pathogenic toxin is removed, yang qi can rise, and the disease is improved.
From the lumbar spine to foot, the joints of the lower extremity are all intimately connected. Their movements are synchronized in a complex biomechanical dance. Pain in one joint tends to affect the joint above and joint below. Understanding the influence of adjacent-joint disease on the hip can help us better counsel patients undergoing hip surgery. Low-back pathology has been shown to negatively influence outcomes after hip arthroscopy. Ipsilateral knee pain appears to do the same. Patients with femoroacetabular impingement syndrome with ipsilateral knee pain should be counseled that their outcomes may not be quite as good as those without knee pain, but they should be able to expect meaningful improvement of their symptoms, both at the hip and at the knee after hip arthroscopy.
All six hospital sites currently use the ARCHITECT STAT high- sensitive troponin I assay in the assessment of patients with suspected acute coronary syndrome and use sex-specific thresholds upper reference limits (99th centile) to rule out myocardial infarction. This validation phase of up to 10 months will provide baseline information for each site on patients with suspected acute coronary syndrome in whom myocardial infarction is ruled out.
PURPOSE:To obtain an antacid composition capable of keeping pH in the stomach within the optimum range and producible by a simple method. CONSTITUTION:This antacid composition contains an antacid substance, a polymer compound soluble in an acid region and a compound insoluble in an acid region. The composition is produced, e.g. by using a polymer compound soluble in an acid region and a compound insoluble in an acid region as binders and granulating the antacid substance from a primary particle to a tertiary particle. In this production method, the particle size of the antacid substance as the raw material is preferably <=100mum, especially 1 to 50mum. The weight ratio of the antacid substance: the polymer compound soluble in an acid region: the compound insoluble in an acid region is preferably 100:1 to 20:0.5 to 5 especially 100:5 to 10:1 to 3.
A medicinal composition for the prevention or treatment of overactive bladder accompanying nervous disorders. The medicinal composition contains as an active ingredient an indoline derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof. The medicinal composition is useful in the prevention or treatment of overactive bladder accompanying nervous disorders such as cerebrovascular disorder, Parkinson's disease, and myelopathia. In the formula, R represents optionally substituted aliphatic acyl, optionally substituted lower alkyl, optionally substituted aromatic acyl, etc.; R1represents cyano or carbamoyl; and R2 represents optionally substituted lower alkyl. ® KIPO & WIPO 2007
With the increase of cadmium content in the environment, the losses caused by cadmium-induced intestinal diseases to animal husbandry are increasing year by year. However, most of the on-going research activities focus on zoonotic diseases rather than exploring the mechanisms of animal disease occurrence from an anthropogenic environmental perspective. In this study, stressed Hu sheep under cadmium environmental exposure were selected to explore the mechanism of inflammatory bowel disease development. 16 s, untargeted metabolomics and transcriptomic multiomics were used to analyze the changes of their intestinal tract and intestinal contents. The results showed that the beneficial microorganisms (s_Ruminococcus_sp) in the Cd group were significantly decreased and the potentially harmful microorganisms were significantly enriched, and the changes of these microorganisms affected the changes of metabolites (caprylic acid) to a certain extent, resulting in a decrease in fatty acids in the intestine. Due to the combined effect of cadmium ion and fatty acid reduction, the PPAR signaling pathway was inhibited, and the fatty acid transport and binding were further reduced, causing very serious damage to the intestine. We revealed for the first time the mechanism of intestinal injury in Hu sheeps under cadmium environmental exposure and provided new prevention and treatment methods of intestinal diseases under the environmental exposure to trace metals.
PURPOSE: A manufacturing method of porous CeO2 composite powder is provided to have micron-size which can limit skin penetration by combining nano-powder, SiO2 nano-powder, and organic template and manufacturing porous CeO2-SiO2 composite powder. CONSTITUTION: A manufacturing method of porous CeO2 composite powder comprises next steps: manufacturing colloid solution by mixing CeO2, SiO2, and organic template; spraying the colloidal solution in a microdroplet form; obtaining CeO2-SiO2- organic template type compound powder by desiccating the colloidal droplet; and obtaining porous CeO2-SiO2 compound powder by eliminating the organic template from the compound powder. A content amount of the mixed nano-powder of CeO2 and SiO2 in the colloidal solution is 1-10wt%. CeO2 content amount in the mixture of SiO2 and CeO2 is 5- 50wt%. A weight of the organic template is 0.5-6 times of the mixture of CeO2 and SiO2. The CeO2 is manufactured by using a flame spray pyrolysis.
1,269,616. Antibacterial compositions. CEDONA HAARLEMMER PHARMACEUTISCHE FABRIEK N.V. 4 Sept., 1970 [12 Sept., 1969], No. 42545/70. Heading A5B. Antibacterial compositions comprise an effective amount of nitrofurantoin and deglycyrrhizinized liquorice in an amount sufficient to reduce the side effects of the nitrofurantoin. The deglycyrrhizinized liquorice may be present in an amount of one fourth to ten times the amount of nitrofurantoin, by weight. The compositions may be administered orally in the form of tablets or capsules particularly in the treatment of urinary tract infections.
Biofeedback is a behavioral treatment without known side effects. In biofeedback patients learn control over bodily reactions through feedback visualised on a screen. Typical bodily reactions that are displayed is heart rate and muscle tension. Biofeedback has for decades been considered as effective preventive treatment of migraine among children and adolescents. In spite of that, it is not available to most patients in need. This is most likely because it requires specialised stationary equipment and a trained therapist.

In this project, the researchers have developed a new smartphone biofeedback app connected to wearable, wireless sensors measuring muscle tension, finger temperature and heart rate. The app and sensors will be used to deliver biofeedback treatment to adolescents suffering for migraine. The goal of the study is to investigate the effect of the biofeedback treatment and the sham-biofeedback treatment on migraine headaches.
PURPOSE: To carry out setting of a pessary into the interior of a body continuously and to make it possible to recover the pessary simply and surely, by putting a controlled release and swelling high polymer solid into a pouch and attaching a recovering string to get rid of the pessary onto the both edge parts at the opening side of the pouch after its usage. CONSTITUTION: A high polymer solid 6 is substantially dry, constituted of cross- linked polyethylene glycol, and expands when it swells through contacting with body fluid. The high polymer material controls discharging of a pharmacodynamically activated material by its diffusion. A pouch 2 is net- formed, and uses a knit thread which is made by a one thread lilliput knitting machine using Dacron(R) or diolen(R) as a material. The seamless pouch is made by a circle knitting method. One end of the pouch is closed and the other end has an opening inlet 16 for filling the high polymer material when the material is manufactured. The opening inlet is reinforced by a top closing cloth 4, which is made through knitting the same polyester thread with high density.  A recovering braid consists of both edge parts 8, 10, and a central part 12 arranged along both ends of the pouch and its closed end, and is sewed on when manufacturing the pouch.
Jehovah's witnesses having undergone cardiac surgery between 1991 till 2012. Blood perfusions refused.
BACKGROUND: Although disease-causal genetic variants have been found within silencer sequences, we still lack a comprehensive analysis of the association of silencers with diseases. Here, we profiled GWAS variants in 2.8 million candidate silencers across 97 human samples derived from a diverse panel of tissues and developmental time points, using deep learning models.
RESULTS: We show that candidate silencers exhibit strong enrichment in disease-associated variants, and several diseases display a much stronger association with silencer variants than enhancer variants. Close to 52% of candidate silencers cluster, forming silencer-rich loci, and, in the loci of Parkinson's-disease-hallmark genes TRIM31 and MAL, the associated SNPs densely populate clustered candidate silencers rather than enhancers displaying an overall twofold enrichment in silencers versus enhancers. The disruption of apoptosis in neuronal cells is associated with both schizophrenia and bipolar disorder and can largely be attributed to variants within candidate silencers. Our model permits a mechanistic explanation of causative SNP effects by identifying altered binding of tissue-specific repressors and activators, validated with a 70% of directional concordance using SNP-SELEX. Narrowing the focus of the analysis to individual silencer variants, experimental data confirms the role of the rs62055708 SNP in Parkinson's disease, rs2535629 in schizophrenia, and rs6207121 in type 1 diabetes.
CONCLUSIONS: In summary, our results indicate that advances in deep learning models for the discovery of disease-causal variants within candidate silencers effectively "double" the number of functionally characterized GWAS variants. This provides a basis for explaining mechanisms of action and designing novel diagnostics and therapeutics.
PROBLEM TO BE SOLVED: To improve sealing performance and the stability of a plaster agent containing a medicine by making the innermost layer of a plurality of layers forming a packed body of a plaster agent containing a medicine other then nitroglycerine using an ethylene-(meth)acrylic acid copolymer. SOLUTION: A packed body of a plaster agent 1 containing a medicine other than nitroglycerine is made up of a laminate of a plurality of layers... a PET layer 2, a PE layer 3, an aluminum foil layer 4 and the innermost layer 5. The innermost layer 5 is made of an ethylene-(meth)acrylic acid copolymer. The ethylene-(meth)acrylic acid copolymer preferably contains about 5-20wt.% of (meth)acrylic acid. When the content is below the value, barrier performance is lowered and when it exceeds the value, the polarity becomes too high to make the medicine easily transfer. The content is more preferably about 6-15wt.%. The number of layers to be laminated is preferably about 2-5. The thickness of the innermost layer 5 is preferably about 5-50μm.