anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In this study, we investigated the role of hypoxia in the development of chronic inflammatory bowel disease (IBD), focusing on its impact on the HIF-1α signaling pathway through the upregulation of lipocalin 2 (LCN2). Using a murine model of colitis induced by sodium dextran sulfate (DSS) under hypoxic conditions, transcriptome sequencing revealed LCN2 as a key gene involved in hypoxia-mediated exacerbation of colitis. Bioinformatics analysis highlighted the involvement of crucial pathways, including HIF-1α and glycolysis, in the inflammatory process. Immune infiltration analysis demonstrated the polarization of M1 macrophages in response to hypoxic stimulation. In vitro studies using RAW264.7 cells further elucidated the exacerbation of inflammation and its impact on M1 macrophage polarization under hypoxic conditions. LCN2 knockout cells reversed hypoxia-induced inflammatory responses, and the HIF-1α pathway activator dimethyloxaloylglycine (DMOG) confirmed LCN2's role in mediating inflammation via the HIF-1α-induced glycolysis pathway. In a DSS-induced colitis mouse model, oral administration of LCN2-silencing lentivirus and DMOG under hypoxic conditions validated the exacerbation of colitis. Evaluation of colonic tissues revealed altered macrophage polarization, increased levels of inflammatory factors, and activation of the HIF-1α and glycolysis pathways. In conclusion, our findings suggest that hypoxia exacerbates colitis by modulating the HIF-1α pathway through LCN2, influencing M1 macrophage polarization in glycolysis. This study contributes to a better understanding of the mechanisms underlying IBD, providing potential therapeutic targets for intervention.
Do not exceed recommended dosage.

Sympathomimetic amines should be used judiciously and sparingly in patients with hypertension, diabetes, ischemic heart disease, hyperthyroidism, increased intraocular pressure or prostatic hypertrophy (See CONTRAINDICATIONS). Sympathomimetic amines may produce CNS stimulation with convulsions or cardiovascular collapse with accompanying hypotension. The elderly (60 years and older) are more likely to exhibit adverse reactions. Antihistamines may cause excitability, especially in children. At doses higher than the recommended dose, nervousness, dizziness or sleeplessness may occur. Administration of dextromethorphan may be accompanied by histamine  
release and should be used with caution in atopic children.
PURPOSE:To stably obtain a homogeneous and safe human immunoglobulin GFc region protein useful as immunological medicines, etc., in a large amount, by cultivating a specific microorganism in a culture medium. CONSTITUTION:A human IgG-producing cell, such as human myelomatous cell ARH77 strain, etc., is propagated to provide cells, which are then subjected to treatment, such as enzymic treatment, to afford a human chromosomic DNA (A). The component (A) is subsequently treated with a restriction enzyme to provide a human genetic library, which is then subjected to genetic operation to afford a human IgGFc region gene (B). The obtained component (B) is treated with a restriction enzyme to link a promoter SD sequence, etc., to the Fc gene to afford an expression type human IgGFc region gene (C), which is then inserted into a plasmid to provide an expression type plasmid. The resultant expression type plasmid is introduced into Escherichia coli, etc., to afford a recombinant microorganism (D), which is subsequently cultivated. The obtained culture is separated and purified to recover the aimed human IgGFc region protein containing a polypeptide of the sequence No.2 (Thr) to No.224 (Lys), such as an amino acid sequence expressed by the formula, without any human-derived proteins.
Cisplatin-based chemotherapy represented the backbone of treatment of advanced NSCLC. However, several trials comparing platinum versus non-platinum based chemotherapy regimens failed to demonstrate a statistically significant difference in terms of time to tumor progression or survival. Newer agents such as gemcitabine, docetaxel and vinorelbine have shown significant activity in the treatment of NSCLC. Gemcitabine/vinorelbine combination as first line treatment has demonstrated a response rate (RR) of 18-43% and a median overall survival (OS) of 9.8-13 months. Similarly, the gemcitabine/docetaxel combination has shown a RR 32-35% and a median OS of 9-12 months. Given their proven efficacy, the combination of these two doublets, would be interesting.
Bleomycin (BLM)-induced lung injury in mice is a valuable model for investigating the molecular mechanisms that drive inflammation and fibrosis and for evaluating potential therapeutic approaches to treat the disease. Given high variability in the BLM model, it is critical to accurately phenotype the animals in the course of an experiment. In the present study, we aimed to demonstrate the utility of microscopic computed tomography (µCT) imaging combined with an artificial intelligence (AI)-convolutional neural network (CNN)-powered lung segmentation for rapid phenotyping of BLM mice. µCT was performed in freely breathing C57BL/6J mice under isoflurane anesthesia on days 7 and 21 after BLM administration. Terminal invasive lung function measurement and histological assessment of the left lung collagen content were conducted as well. µCT image analysis demonstrated gradual and time-dependent development of lung injury as evident by alterations in the lung density, air-to-tissue volume ratio, and lung aeration in mice treated with BLM. The right and left lung were unequally affected. µCT-derived parameters such as lung density, air-to-tissue volume ratio, and nonaerated lung volume correlated well with the invasive lung function measurement and left lung collagen content. Our study demonstrates the utility of AI-CNN-powered µCT image analysis for rapid and accurate phenotyping of BLM mice in the course of disease development and progression.NEW & NOTEWORTHY Microscopic computed tomography (µCT) imaging combined with an artificial intelligence (AI)-convolutional neural network (CNN)-powered lung segmentation is a rapid and powerful tool for noninvasive phenotyping of bleomycin mice over the course of the disease. This, in turn, allows earlier and more reliable identification of therapeutic effects of new drug candidates, ultimately leading to the reduction of unnecessary procedures in animals in pharmacological research.
This invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The aim of the invention is the application of gel-like cubic mesophases of the monooleine-water system as an implantable active ingredient depot for the treatment of tumors during oncological therapy and in gene therapy. A rational membrane design has been developed to control the release of the active ingredient over time and to control the amount released. The implantable active ingredient according to the invention consists of a lipid matrix which is capable of forming cubic phases in which modifier-molecules have been integrated and contains pharmaceutically active substances. Monooleine is the preferred lipid matrix.
System and methods provide for a reward management system for prescribed treatment protocol. The methods and system provide an interface to remotely access, monitor and reward a patient/user for compliance to a prescribed medical treatment by providing reward points. The reward points can be redeemed by the patient for goods and services. The method collects the medical data of the patient using one or more medical devices. The captured medical data can be converted into events based on the medical data and user attributes. The events are transformed with a set of rules into reward points by implementing predefined rules. The reward points are converted into promissory notes, which can be redeemed for tangible goods and/or services.
<P>PROBLEM TO BE SOLVED: To perform diagnosis to support optimization of a computer system.  <P>SOLUTION: A server 1 includes: a receiving means consisting of a communication section 101, and an image distribution section 104; a storage section 105, a detecting section 109; and a preparing section 111. The receiving means receives apparatus information regarding a plurality of viewers and user information showing users of the plurality of viewers from the viewer side. The storage section 105 stores the apparatus information and the user information corresponding to the apparatus information by associating them with each other. The detecting section 109 detects a state that there are viewers with high frequency of use and viewers with low frequency of use among the plurality of viewers on the basis of the information to be stored in the storage section 105. The preparing section 111 prepares a plan to prompt shift of the viewers with low frequency of use, detected by the detecting section 109 to a room where the viewers with high frequency of use are installed, or to promote a part of the users of the viewers with high frequency of use to use the viewers with low frequency of use.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Intervention: Patients allocated to the intervention group receive weekly counselling sessions in 6 weeks as an integrated prehabilitation program tailored to meet the individual patient's need for risk reduction at surgery. It is introduced via the surgical 'Engage in the process of change'. The smoking and alcohol cessation intervention follows the Gold Standard Programme and patients in the intervention group are introduced to a standardized exercise training programme taking individualized needs into account. Nutritional support is also individualized.
The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating bovine mastitis and a preparation method, a detection method and application of the medicine. The medicine is prepared from, by weight, 1-2 parts of vitis coignetiae and 1-2 parts of panicum repens. The medicine can be prepared into tablets, pills, powder, hard capsules, soft capsules and granules. The preparation method includes drying the vitis coignetiae and the panicum repens, soaking in 11 times the amount of water for 1 hour for the first time, decocting for 1 hour, adding 4 times the amount of water to decoct for 1 hour for the second time, blending two times of decoction, filtering, concentrating filtrate, drying, grinding into fine powder, sieving and mixing uniformly to obtain the powder. The medicine quality detection method includes that chromatographic condition: HypersilDs chromatographic column; mobile phase: methanol-0.15% phosphoric acid solution in a ratio of 30:70; detection wavelength: 200nm; column temperature: 20 DEG C; flow velocity: 1.0mL per min; sample size: 10 microliters. The medicine is reasonable in composition and remarkable in treatment effect.
OBJECTIVES: The aim of the study was to evaluate the effect of botulinum toxin (BT) injection on fissure healing in the treatment of chronic anal fissure (CAF) in outpatient conditions without any analgesia and sedation to the internal anal sphincter (IAS). The primary outcome measure was post-procedural pain. The secondary outcome measures were fissure healing and complications.
METHODS: Prospectively preserved data of 67 patients who received BT injections for CAF were analyzed prospectively. Demographic data, duration of symptomatic improvement, fissure location and number, parity, post-procedural pain, complications, continence status, response to treatment, and duration of follow-up were examined. Participants received bilateral (50 + 50 units) BT injections into the internal anal sphincter (IAS) in an outpatient setting.
RESULTS: Symptomatic improvement was observed in 58% of patients within 1 week. The complete response rate to treatment was 82% at a mean follow-up of 6 months. Patients with partial response to treatment (10%) were successfully treated with topical therapy, and patients with persisting fissures (8%) were successfully treated with partial lateral internal sphincterotomy (LIS). 14 patients (21%) reported some degree of transient incontinence at follow-up. Multiparous women experienced more symptoms of Incontinence (p = 0.00). Pre- and post-procedural Vas Score median values were 4. The 7th-week VAS score median value was 3.
CONCLUSION: Dysport injection under sedation-free outpatient conditions is an effective and safe alternative to LIS for the treatment of CAF, with tolerable procedural pain. All patients should be warned of transient incontinence.
PURPOSE: To evaluate the safety and efficacy of new staple-line reinforcement (SLR) in pulmonary resection through a prospective study and to compare the results of this study with historical control data in an exploratory study.
METHODS: The subjects of this study were 48 patients who underwent thoracoscopic lobectomy. The primary endpoint was air leakage from the staple line. The secondary endpoints were the location of air leakage, duration of air leakage, and postoperative pulmonary complications.
RESULTS: The incidence of intraoperative air leakage from the staple line was 6.3%. Three patients had prolonged air leakage as a postoperative pulmonary complication. No malfunction was found in patients who underwent SLR with the stapling device. When compared with the historical group, the SLR group had a significantly lower incidence of air leakage from the staple line (6.3% vs. 28.5%, P < 0.001) and significantly shorter indwelling chest drainage time (P = 0.049) and length of hospital stay (P < 0.001).
CONCLUSIONS: The use of SLR in pulmonary resection was safe and effective. When compared with conventional products, SLR could control intraoperative air leakage from the staple line and shorten time needed for indwelling chest drainage and the length of hospital stay.
The present invention discloses a method for preparing a recombinant duck interleukin 2 protein and a purpose thereof. The duck interleukin-2 cDNA fragments enlarged by RT-PCR of various varieties of ducks, a prokaryotic expression carrier pBAD/his B and a eukaryotic expression carrier pMETalpha A construct high-efficiency expression plasmids, and the recombinant expression carriers are respectively induced and expressed after respectively converting colibacillus LMG194 and yeast strains PMAD11 PMAD16. The colibacillus is cracked by ultrasonic waves and centrifugated to remove precipitates so as to obtain the duck interleukin-2 coarse product after being induced, and the duck interleukin-2 pure product is obtained by a protein purification system. The duck interleukin-2 coarse product or the pure product can be used as immunity auxiliary agents, disease resistance additives and medicines for treating diseases after being added with a protecting agent. The preparation processes of a duck interleukin-2 monoclonal antibody and a polyclonal antibody are simple and economic, and can be used as a good immunity inhibiting agent. The recombinant duck interleukin-2 protein prepared by gene engineering technology has the characteristics of simple technology flow, low production cost, good stability, high biological activity, etc.
Of the approximately 3600 subjects ≥18 years of age in clinical studies of PRIMAXIN, including postmarketing studies, approximately 2800 received PRIMAXIN. Of the subjects who received PRIMAXIN, data are available on approximately 800 subjects who were 65 and over, including approximately 300 subjects who were 75 and over. No overall differences in safety or effectiveness were observed between these subjects and younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

No dosage adjustment is required based on age [see Clinical Pharmacology (12.3)]. Dosage adjustment in the case of renal impairment is necessary [see Dosage and Administration (2.3)].
The dysregulation of sex hormone levels is associated with metabolic disorders such as obesity. Inonotus obliquus polysaccharide (IOP) exhibits a promising therapeutic effect on conditions like obesity and diabetes, potentially linked to its influence on intestinal microbiota and metabolism. The exact cause and mechanisms that link sex hormones, gut microbiota and metabolism are still unknown. In this research, we examined the molecular weight, monosaccharide composition, and glycosidic bond type of IOP. We found that IOP mostly consists of alpha-structured 6‑carbon glucopyranose, with a predominant (1 → 4) linkage to monosaccharides and a uniform distribution. Following this, we administered two different concentrations of IOP to mice through gavage. The results of the enzyme-linked immunosorbent assay (ELISA) demonstrated a significant increase in testosterone (T) levels in the IOP group as compared to the control group. Additionally, the results of tissue immunofluorescence indicated that increased IOP led to a decrease in adiponectin content and an increase in SET protein expression. The study also revealed changes in the intestinal microbiota and metabolic changes in mice through 16S rRNA data and non-targeted LC-MS data, respectively. The study also found that IOP mainly affects pathways linked to glycerophospholipid metabolism. In addition, it has been observed that there is an increase in the number of beneficial bacteria, such as the Eubacterium coprostanoligenes group and g.Lachnospiraceae NK4A136 group, while the levels of metabolites that are linked to obesity or diabetes, such as 1,5-anhydrosorbitol, are reduced. Furthermore, biomarker screening has revealed that the main microorganism responsible for the differences between the three groups is g.Erysipelatoclostridiaceae. In summary, these findings suggest that IOP exerts its therapeutic effects through a synergistic interplay between sex hormones, gut microbiome composition, and metabolic processes.
The invention discloses a biomarker for predicting breast cancer progression, which is 4.1R protein. The invention also discloses application of the biomarker as a breast cancer treatment target. And comparing the expression level of 4.1R in the primary tumor sample of the patient with the primary and recurrent triple negative breast cancer, wherein the expression level of 4.1R protein in the primary tumor sample of the patient with the recurrent triple negative breast cancer is obviously low expressed, and the expression level can be used for evaluating the risk of the recurrence of the triple negative breast cancer. According to the invention, 4.1R protein low expression is successfully realized by constructing a 4.1R knockout triple negative breast cancer cell line. 4.1 the low expression of the R protein plays a remarkable role in promoting the growth of triple negative breast cancer cells. 4.1R protein is used as a biomarker for predicting the recurrence of the triple negative breast cancer and an action target of a medicament for treating the breast cancer, and the expression level of the protein can be used for effectively evaluating the occurrence and development of tumors, thereby providing guidance for the treatment of patients with the triple negative breast cancer.
Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
BACKGROUND AND PURPOSE: Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs is unknown. We leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA formation.
METHODS: We performed a two-sample Mendelian randomisation (MR) using publicly available genome-wide association studies summary statistics to investigate the causal relationship between tHcy and IAs, following the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology-MR statement. Furthermore, a propensity score matching (PSM) analysis was conducted to evaluate the detailed effects of tHcy on risk of IA formation by utilizing real-world multicentre data, including 9902 patients with and without IAs (1:1 matched). Further interaction and subgroup analyses were performed to elucidate how tHcy affects risk of IA formation.
RESULTS: MR analyses indicated that genetically determined tHcy was causally associated with IA risk (OR, 1.38, 95% CI 1.07 to 1.79; p=0.018). This is consistent with the more conservative weighted median analysis (OR, 1.41, 95% CI 1.03 to 1.93; p=0.039). Further sensitivity analyses showed no evidence of horizontal pleiotropy or heterogeneity of single nucleotide polymorphisms in causal inference. According to the PSM study, we found that, compared with low tHcy (≤15 µmol/L), moderate tHcy (>15-30 µmol/L) (OR 2.13, 95% CI 1.93 to 2.36) and high tHcy (>30 µmol/L) (OR 3.66, 95% CI 2.71 to 4.95) were associated with a higher IA risk (p trend <0.001). Subgroup analyses demonstrated significant ORs of tHcy in each subgroup when stratified by traditional cardiovascular risk factors. Furthermore, there was also a synergistic effect of tHcy and hypertension on IA risk (p interaction <0.001; the relative excess risk due to interaction=1.65, 95% CI 1.29 to 2.01).
CONCLUSION: Both large-scale genetic evidence and multicentre real-world data support a causal association between tHcy and risk of IA formation. Serum tHcy may serve as a biomarker to identify high-risk individuals who would particularly benefit from folate supplementation.
The invention discloses a serial Chinese medicinal preparation for treating phaseolus cold, a preparation process and a quality control method thereof. Preparations are characterized by being prepared from traditional Chinese medicines, namely platycodon root, tangerine peel, indigowoad leaf, weeping forsythiae, nutgrass galingale rhizome, perilla leaf, fineleaf schizonepeta herb, divaricate saposhnikovia root and liquoric root as well as pharmaceutical excipients. The preparation has the effects of clearing away heat and relieving exterior syndromes, and is used for symptoms such as fever and headache, running nose, cough and dry mouth and the like caused by phaseolus cold. Volatile oil is a material base of clearing away heat and relieving exterior syndromes of the preparation; and the traditional preparation process is to adopt a way of spraying the volatile oil into the preparation, and the volatile oil is almost completely lost during the production and storage due to the low content of the volatile oil, so that the clinical therapeutic effect is seriously affected. In the preparation process, a volatile oil inclusion process is adopted, so the loss of the volatile oil during the production and storage is reduced, and the stability of a medicine is improved and the clinical therapeutic effect of the medicine is ensured at the same time. In addition, the more perfect quality control method is used for ensuring the quality; meanwhile, the clinical medication formulation is also enriched, so that the clinical medication demand can be better met.