anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Arsenic-contaminated drinking water can induce various disorders by disrupting lipid and glucose metabolism in adipose tissue, leading to insulin resistance. It inhibits adipocyte development and exacerbates insulin resistance, though the precise impact on lipid synthesis and lipolysis remains unclear. This review aims to explore the processes and pathways involved in adipogenesis and lipolysis within adipose tissue concerning arsenic-induced diabetes. Although arsenic exposure is linked to type 2 diabetes, the specific role of adipose tissue in its pathogenesis remains uncertain. The review delves into arsenic's effects on adipose tissue and related signaling pathways, such as SIRT3-FOXO3a, Ras-MAP-AP-1, PI(3)-K-Akt, endoplasmic reticulum stress proteins, CHOP10, and GPCR pathways, emphasizing the role of adipokines. This analysis relies on existing literature, striving to offer a comprehensive understanding of different adipokine categories contributing to arsenic-induced diabetes. The findings reveal that arsenic detrimentally impacts white adipose tissue (WAT) by reducing adipogenesis and promoting lipolysis. Epidemiological studies have hinted at a potential link between arsenic exposure and obesity development, with limited research suggesting a connection to lipodystrophy. Further investigations are needed to elucidate the mechanistic association between arsenic exposure and impaired adipose tissue function, ultimately leading to insulin resistance.
Many patients with heart failure exhibit a distinctive abnormal cyclical breathing pattern, 'periodic breathing'. This means that patients have a worse prognosis and they have debilitating symptoms including breathlessness, fatigue and disrupted sleep. Many of these patients also have cardiac pacemakers fitted, to improve their heart function. We have discovered a new physiological mechanism linking the heart and lungs, and have shown that by changing the programmed settings of a cardiac pacemakers, we can change a patient's breathing. If we increase the programmed pacing heart rate, we increase the rate of delivery of carbon dioxide to the lungs temporarily, which increases ventilation. When we reduce the programmed pacing heart rate, the converse happens. We aim to demonstrate this phenomenon scientifically, and to use this information to stabilise periodic breathing in heart failure patients using pacemakers. We then plan to continue to investigate whether we can show that sleep quality is improved in heart failure patients with periodic breathing, by our pacing protocol.
The effects of follicle-stimulating hormone (FSH) have been poorly studied. In women, FSH is involved in estrogen production, while in men regulates spermatogenesis. On the other hand, in women, menopause is associated with an increase in the risk of cardiovascular disease and the concentration of FSH rises. It is unclear whether such an increase has any effect on the development of atherosclerosis. Endothelial dysfunction represents an early trigger of atherosclerosis. Since estrogens can directly stimulate endothelial function and increase in response to FSH administration, males might represent a potential model to study the effcts of FSH independent from estrogens.Purpose of the study will be to evaluate the effects of the s.c. administration of 300 IU of FSH in 16 healthy males. The endothelial function will be evaluated by the measurement with ecographic approach of the flow mediated dilation (FMD) of the brachial artery. The FMD will be measured before and 6, 12, 24 or 48 hours after FSH or placebo adiministration in the same subjects studied 2 weeks apart. The results will help to clarify whether perturbation of FSH, similar to the one observed in women after the menopause, affects endothelial function.
The invention belongs to a traditional Chinese medicine and discloses a traditional Chinese medicine for treating upper gastrointestinal hemorrhage. The traditional Chinese medicine for treating upper gastrointestinal hemorrhage comprises 15g of rheum officinale, 25g of pilose asiabell root, 15g of coptis root and 10g of radix astragali. The above traditional Chinese medicine ingredients and water are decocted into a thick decoction. One dose of the thick decoction is divided into 2-3 parts and the 2-3 parts of the decoction are taken at different times in a day. In a treatment course, the traditional Chinese medicine is used for continuous seven days. The traditional Chinese medicine is designed according to the traditional Chinese medicine syndrome differentiation theory, has a simple formula, utilizes the easily acquired raw materials, has a low cost, high curative effects and no toxic or side effect, and can regulate the human body to a normal state.
A system ( 100 ) for assessing a subject at risk of a soft tissue abnormality such as deep vein thrombosis (DVT), comprises a motion sensor ( 108 ) which is adapted to be fixed, in use, to a muscle ( 106 ) of the subject. The motion sensor includes a transmitter ( 206 ) configured to transmit a signal ( 400 ) representing motion of the sensor. A receiver ( 118 ) is configured to receive the signal from the transmitter of the motion sensor. A signal processor ( 112 ) is coupled to the receiver and configured to analyse first and second data sets received via the receiver from the motion sensor. The first and second data sets represent respective first and second oscillatory mechanical responses of first and second muscles of the subject resulting from mechanical stimuli. The analysis comprises determining first and second parameter sets characterising the first and second oscillatory mechanical responses, and comparing the first parameter set with the second parameter set to assess a possible presence of DVT in the subject.
Hotspot KRAS mutations exist in various cancers, especially pancreatic, lung and colorectal cancer. Mutations in KRAS are implicated in the development of pancreatic cancer and are associated with poor prognosis of the patients. KRAS is an attractive target for cancer treatment because it is a driver mutation and is likely expressed by all cells in a tumor. Recently,T cells targeting mutant KRAS have been identified in patients with epithelial cancers, and these T-cell receptors (TCR) have been characterized. For example, TCRs that target mutant KRAS G12D peptides presented by HLA-C\*08:02, and a TCR that targets a KRAS G12V peptide presented by HLA-A\*11:01 have been identified. Mutant KRAS-reactive T cells appear capable of inducing tumor regression as highlighted in a patient with metastatic colorectal cancer who experienced regression of metastatic tumors after infusion of HLA-C\*08:02-restricted KRAS-G12D reactive tumor-infiltrating lymphocytes (TIL). The investigators will test the safety and activity of adoptive transfer of autologous T cells genetically engineered to express a TCR that targets mutant KRAS G12V in the context of HLA-A\*11:01 in HLA-matched patients with advanced pancreatic cancer that express mutant KRAS G12V. The investigators will also measure the in vivo survival of engineered T cells.
Abstract A system and associated method are provided for fulfillment of medication requisitions corresponding to contained medication units. Requisition fulfillment logic may be included to provide decision data to a patient care provider for use in selecting one of a plurality of different fulfillment sites to fill a given medication requisition. A requisition router may route the medication requisition to a selected one of the plurality of fulfillment sites. The fulfillment sites may provide medication requisition metadata (e.g., data relating to the preparation and handling of medication units) to a medication requisition database in corresponding relation to the corresponding medication requisitions fulfilled by the fulfillment sites. The medication requisition metadata may be stored in the medication requisition database and accessed to facilitate enhanced management functionalities in relation to medication units dispensed by patient care providers. MEDICATION REQUISITION 100 MEDICATION MANAGEMENT NETWORK REQUISITION PATIENT CARE PROVIDER REQUISITION REQUISITION' -- -- -- ---- --- + FULFILLMENT -0---- - -- - I LOGIC I60b 60a 40 REMOTE REQUISITION REMOTE FULFILLMENT ROUTER ---- FULFILLMENT \J- \ PHARMACY FULFILLMENT S7TE]
Each of a plurality of edge computing devices are configured to receive datastreams generated by at least one sensor forming part of a respective medical device (e.g.,a sensor-equipped surgical tool, etc.) which, in turn, characterizes use of the respectivemedical device in relation to a particular patient. Each of the edge computing devices canexecute at least one machine learning model which generates or from which modelattributes are derived. The generated model attributes are anonymized using ananonymization technique such as k-anonymity. The anonymized generated modelattributes are homomorphically encrypted and transmitted to a central server. Encryptedmodel attribute updates to at least one of the machine learning models are later receivedfrom the central server which results in the machine learning models executing on one ormore of the edge computing devices to be updated based on the received encrypted modelattribute updates.
Brief education about suicidal behaviour and follow up contacts for 6 months in addition to treatment as usual. follow up will occur at the following time points post discharge: weeks 1, 2, 4, 6, 8, 12, 16 and 20. this will occur in addition to treatment as usual.
1293375 Valves SEALAND ENG (KEIGHLEY) Ltd 4 June 1970 [5 June 1969] 28531/69 Heading F2V  A valve comprises a spring loaded spindle 4 extending through a valve seat 3, and carrying on one side of the'seat a closure member 5 and on the side remote from the closure member an operating mechanism including a trip linkage to allow the valve to close freely under the spring. The mechanism consists of an adjustable mounting member 8 in which the spindle is slidably mounted. The spindle is screwthreadedly engaged in a yoke 10 positioned outwardly of the member 8. The yoke is connected to the member 8 through a linkage 12, 13 adapted in one position shown to hold the valve open, and when pivoted away from this position to release the yoke and allow the valve to close. As shown, the pairs of' longer and shorter links 13, 12 are pivotably connected by a cross pin 13a to which a trip wire (26), Fig. 1 (not shown), may be attached, or instead, the linkage may be operated by e.g. an hydraulic actuator. The mounting member 8 is adjustable by a thread and lock nut 9 to suit the desired direction of the trip wire. The seat 3 is clamped between angularly adjustable inlet and outlet body parts 2, 25.
FIELD: medicine, geriatrics. SUBSTANCE: invention proposes biologically active compound tetrapeptide L-alanyl-L-glutamyl-L-asparagyl-glycine of the general formula: L-Ala-L-Glu-L-Asp-Gly and its using as agent showing geroprotective activity. Pharmacological agent containing effective amount of tetrapeptide or its salt as an active component is proposed for parenteral, intranasal, oral and topical using. Method of prophylaxis of early ageing involves prophylactic and/or curative administration in patient the pharmacological agent in doses 0.01-100 mcg/kg of body mass, at least once for period that is necessary to obtain the therapeutic effect. Invention can be used for prophylaxis of early body ageing. EFFECT: enhanced effectiveness of agent. 11 cl, 17 tbl, 10 ex
The present invention provides a  Bifidobacterium animalis  subsp.  lactis  strain BLa36 for relieving constipation, a method for culturing same, and use thereof. The  Bifidobacterium animalis  subsp.  lactis  strain BLa36 for relieving constipation is designated as  Bifidobacterium animalis  subsp.  lactis  BLa36, which has been deposited at the China General Microbiological Culture Collection Center on Dec. 2, 2021, with an accession number of CGMCC No. 24029, and the address for the deposition is Yard No. 1(3), West Beichen Road, Chaoyang District, Beijing, China. The  Bifidobacterium animalis  subsp.  lactis  has good resistance to stomach acid and can relieve constipation.
The aim of this perspective is to promote the theory of salutogenesis as a novel approach to addressing ophthalmologic inflammatory conditions, illustrating several concepts in which it is based upon and how they can be applied to medical practice. This theory can better contextualize why patients with similar demographics and exposures are not uniform in their clinical presentations. Stressors in daily life can contribute to a state of ill-health and there are various factors that help alleviate their negative impact. These alleviating factors are significantly impaired in people with poor vision, one of the most common presentations of ophthalmologic conditions. Salutogenic principles can guide the treatment of eye conditions to be more respectful of patient autonomy amidst shifting expectations of the doctor-patient relationship. Being able to take ownership of their health and feeling that their cultural beliefs were considered improves compliance and subsequently gives more optimal outcomes. Population-level policy interventions could also utilize salutogenic principles to identify previously overlooked domains that can be addressed. We identified several papers about salutogenesis in an ophthalmological context and acknowledged the relatively few studies on this topic at present and offer directions in which we can explore further in subsequent studies.
The procedure to place a PIVC includes these steps: before inserting the catheter, the nurse will perform routine preliminary (non sterile) inspection of the arm to identify an insertion site. After selecting the insertion site, the nurse will release the tourniquet, with non-sterile gloves, and disinfect the skin around the insertion site. While allowing the antiseptic to act, the nurse will apply the tourniquet, and pull lightly with the thumb of the non-dominant hand to keep the vein from moving. The needle will be inserted at a 10-30 degree angle about 1-2 cm distal from the catheter insertion site. Holding the needle firmly, the nurse will advance the cannula for its entire length into the lumen, remove the needle, and connect the cannula via an extension to a 3-way stopcock. A transparent, semi-permeable dressing will allow for daily visual inspection of the insertion site.
The invention provides a multifunctional traditional Chinese medicine liquid beneficial to human bodies, which is prepared by mixing a plurality of traditional Chinese medicines into a traditional Chinese medicine composition and tempering the traditional Chinese medicine composition and himalayan salt into the traditional Chinese medicine liquid. The traditional Chinese medicine composition has the advantages of reasonable prescription proportion, complementary and reinforcing effects among the components, low cost, convenient preparation and good treatment effect. The formula ingredients of the traditional Chinese medicine bath lotion can be prepared into traditional Chinese medicine bath lotion which has health care effect on feet, heads and bodies of human bodies. And can also treat body cold, body cold and foot cold, and has effects of dredging channels and collaterals, improving sleep, eliminating dampness, tranquilizing mind, improving sleep, clearing heat from scalp, removing dandruff, promoting hair growth, blackening hair, nourishing hair, consolidating hair, and smoothing hair. The invention has simple and easy operation and easy acceptance, and the patients can avoid taking the medicine without any toxic and side effect. On one hand, the fumigation mode can accelerate the metabolism of the human body and promote the blood circulation through steam, and has the effects of sweating, fever reduction and the like; on the other hand, the drug effect can directly reach the focus through the skin, and the obvious effects of dredging collaterals, relieving pain, promoting blood circulation, removing blood stasis, eliminating dampness and eliminating evil are achieved.
Bispecific molecules which react both with the high-affinity Fc gamma receptor of human effector cells and with a virus or virus component are disclosed. Binding of the molecules to the Fc receptors found on effector cells is not blocked by human immunoglobulin G. The molecules are useful for targeting human effector cells (e.g. macrophages) against a viral target (e.g. HIV or BIV-infected cell). For this purpose, bispecific molecules can be constructed containing the binding region derived from an anti-Fc gamma  receptor antibody and the CD4 molecule or CD4 binding domain of the envelope glycoprotein gp120 of BIV. Alternatively, bispecific antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc receptor antibody and the binding region of HIV-specific antibody such as anti-gp120 antibody. Targeted effector cells can be used to kill virus by cell mediated antibody dependent cytolysis.
BACKGROUND: The financial burden of tuberculosis (TB) can hinder patients and their families, creating obstacles throughout the care cascade, despite TB prevention and control being provided free of charge. In Myanmar, patients can visit private providers operating under public-private mix (PPM) schemes, where TB services (diagnosis and treatment) are typically offered at no cost. The study focused on quantifying the financial burden faced by TB patients seeking care from Myanmar's PPM providers.
METHODS: This cross-sectional telephone survey included 695 adults seeking TB treatment [drug-susceptible TB (DS-TB) and retreatment TB] from various private providers in four states and regions with high TB burden in Myanmar. Telephone interviews were conducted in May and June 2022. Both direct and indirect costs incurred from the patient and their household perspective were valued in 2022 and estimated throughout pre- and post-TB treatment episodes. The TB-affected households were defined as experiencing catastrophic health expenditure if their expenditure due to TB exceeded 20% of their capacity to pay, as recommended by the World Health Organization. All cost data were collected in Myanmar Kyats (MMK) and converted to USD (1 USD = 1850 MMK as of July 20, 2022). Logistic regression analysis was done to identify the determinants of catastrophic health expenditure.
RESULTS: The findings showed patients made a median of 7 times for clinic visits throughout their treatment, with the median total cost for the entire TB treatment being 53.4 US dollars (USD), including direct medical and testing costs (11.9 USD) and direct non-medical patient expenditure (11.6 USD). Pre-treatment costs were higher compared to post-treatment costs (the intensive phase and continuation phase). During the intensive phase, TB care cost was nearly free, but during the continuation phase, it was a median of 2.6 USD. About 34.5% of patients experienced catastrophic health expenditure due to TB treatment, with expenses exceeding 20% of their capacity to pay. Multivariate regression analysis revealed that patients with a history of hospitalization (aOR = 14.84; P < 0.01), seeking care from regions other than Yangon (aOR = 2.6; P < 0.01), and using coping strategies (aOR = 12.53; P < 0.01), were more likely to face catastrophic financial burdens. Higher monthly household income (over 162 USD) was associated with a decreased risk of incurring catastrophic health expenditure (aOR = 0.38; P < 0.01).
CONCLUSIONS: TB patients and their households in Myanmar faced risk of catastrophic costs, even when treated in the private sector with free diagnostic charges and anti-TB medicine. The study highlighted the need for additional strategies or policies to make TB care affordable and mitigate the financial burden of TB-affected households.
The invention comprises copolymers of (a) vinyl acetate, (b) crotonic acid and (c) at least one acrylic or methacrylic ester of the formula <FORM:1103284/C3/1> where R represents hydrogen or methyl and R1 is methyl, butyl, ethylhexyl, butoxyethyl or lauryl or alkyl vinyl ether of formula <FORM:1103284/C3/2> where R11 is ethyl, isopropyl, butyl, isobutyl or chloroethyl, and salts of these copolymers.  The copolymers preferably contain 75 to 85% by weight of vinyl acetate, 5 to 15% by weight of crotonic acid and 5 to 15% by weight of component (c).  Suitable salts include those with ammonia, monoethanolamine, monoethylamine, dimethylamine, diethylamine, aminoethylamine, ethanolamine, monoisopropanolamine, 2 - amino - 2 - methyl - propanol - 1, or 2 - amino - 2 - methyl - propanediol - 1,3. Solutions of the salts, preferably in the form of aerosol lacquers, may be used as cosmetics.  The aerosol lacquer may contain alcohol and a propellant gas preferably a halogenated hydrocarbon.ALSO:Aerosol compositions comprise solutions of salts of copolymers of (a) vinyl acetate; (b) crotonic acid; and (c) at least one acrylic or methacrylic ester of the formula <FORM:1103284/C4-C5/1> where R is hydrogen or methyl and R1 is methyl, butyl, ethylhexyl, butoxyethyl or lauryl or alkyl vinyl ether of the formula CH2 = CH-O-R11, where R11 is ethyl, isopropyl butyl, isobutyl or chloroethyl.  The aerosol lacquers are used as cosmetic products and also contain alcohols and propellant gas. Preferred alcohols are anhydrous ethanol or isopropanol and preferred propellant gases are halogenated hydrocarbons.  In examples fluorinated hydrocarbons, butyl phthalate, ethyl alcohol, isopropyl palmitate, triethylene glycol, water and isopropyl myristate are used.ALSO:Hair lacquers and lotions comprise solutions of salts of copolymers of (a) vinyl acetate, (b) crotonic acid and (c) at least one acrylic or methacrylic ester of the formula <FORM:1103284/A5-A6/1> where R is hydrogen or methyl and R1 is methyl, butyl, ethylhexyl, butoxyethyl or lauryl or alkyl vinyl ether of the formula CH2=CH-O-R11 where R11 is ethyl, isopropyl, butyl, isobutyl or chloroethyl.  The products are preferably in the form of aerosol lacquers which preferably include alcohols and propellant gases.  Preferred alcohols are anhydrous ethanol or isopropanol and preferred propellant gases are halogenated hydrocarbons.  In Examples fluorinated hydrocarbons, butyl pthalate, ethyl alcohol, isopropyl palmitate, triethylene glycol, water and isopropyl myristate are used. Conventional cosmetics additives, e.g. plastisizers, perfumes and dyestuffs may also be incorporated.
PURPOSE: A pharmaceutical composition containing the water extract of Cordyceps militaris and Inonotus obliquus as an effective ingredient is provided. The composition exhibits excellent effect on various types of diabetes, in particular Type 1 and type 2 diabetes without causing any adverse side effect and is thus used as drugs and foods for prevention and treatment of diabetes. CONSTITUTION: The pharmaceutical composition contains 50 to 90 parts by weight of a Cordyceps militaris extract and 10 to 50 parts by weight of Inonotus obliquus. The dose of the composition is 60mg/kg/day. The composition is formulated into the shape of granules, powders, coated tablets, tablets, capsules, extracts, suppositories, syrups, juices, suspensions, emulsions and slow release formulations of active compounds. The extract is used for foods for treatment of diabetes by adding vitamins, flavorings, natural carbohydrate or the like.