anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
MoS2 nanosheets belong to an emerging family of nanomaterials named bidimensional transition metal dichalcogenides (2D TMDCs). The use of such promising materials, featuring outstanding chemical and physical properties, is expected to increase in several fields of science and technology, with an enhanced risk of environmental dispersion and associated wildlife and human exposures. In this framework, the assessment of MoS2 nanosheets toxicity is instrumental to safe industrial developments. Currently, the impact of the nanomaterial on the nervous tissue is unexplored. In this work, we use as in vivo experimental model the early-stage zebrafish, to investigate whether mechano-chemically exfoliated MoS2 nanosheets reach and affect, when added in the behavioral ambient, the nervous system. By high throughput screening of zebrafish larvae locomotor behavioral changes upon exposure to MoS2 nanosheets and whole organism live imaging of spinal neuronal and glial cell calcium activity, we report that sub-acute and prolonged ambient exposures to MoS2 nanosheets elicit locomotor abnormalities, dependent on dose and observation time. While 25 μg mL-1 concentration treatments exerted transient effects, 50 μg mL-1 ones induced long-lasting changes, correlated to neuroinflammation-driven alterations in the spinal cord, such as astrogliosis, glial intracellular calcium dysregulation, neuronal hyperactivity and motor axons retraction. By combining integrated technological approaches to zebrafish, we described that MoS2 2D nanomaterials can reach, upon water (i.e. ambient) exposure, the nervous system of larvae, resulting in a direct neurological damage.
Provided are an inhibitor of a decrease in Blood Brain Barrier (BBB) function, an inhibitor of disruption of blood brain barrier tight junctions, an inhibitor of leukocyte infiltration into the CNS, an inhibitor of penetration of IgG in the blood of a patient into the CNS, and a therapeutic agent for neuromyelitis optica lineage disorder, behcet's disease, sarcoidosis of the nervous system, lupus of the central nervous system (neuropsychiatric lupus), autoimmune encephalitis, or ford-salix integra-protopanasis, which inhibits a decrease in blood brain barrier function and/or restores a decreased blood brain barrier function, comprising: an antibody comprising a heavy chain variable region comprising CDR1 having the sequence of SEQ ID NO. 1, CDR2 having the sequence of SEQ ID NO. 2, and CDR3 having the sequence of SEQ ID NO. 3 and a light chain variable region comprising CDR1 having the sequence of SEQ ID NO. 4, CDR2 having the sequence of SEQ ID NO. 5, and CDR3 having the sequence of SEQ ID NO. 6.
The study recruited and briefly monitored 27 patients at the outpatient department and the medical ward of the Pulmonology Department of "G. Papanikolaou" General Hospital of Thessaloniki, Greece, as well as the 1st Intensive Care Unit of the same Hospital. Patients were recruited during their hospitalization or at the outpatient setting and informed consent was obtained before participation. They were examined with spirometry, manual auscultation of the thorax and where necessary, with chest X-ray or CT scan. They wore the WELMO sensors vest for a period of 15-20 minutes during which they performed tidal and deep breathing, cough and spirometry maneuvers and changes of posture. At the end of the study, they were requested to fill in a questionnaire about comfort and usability of the vest.

Patients from various thoracic disease categories were included from both sexes and aged 18-90 years. The study was approved by the bioethics committee of the Hospital and personal data protection provisions were in place. The obtained signals (lung sounds and EIT signals) were examined for consistency with conventionally obtained medical data and the usability, comfort, patient acceptance and practicality of the WELMO vest was assessed.
Heart failure (HF) represents the terminal stage of cardiovascular diseases, with limited therapeutic options currently available. Calotropin (CAL), a cardenolide isolated from Calotropis gigantea, exhibits a similar chemical structure and inhibitory effect on Na+/K+-ATPase to digoxin, a positive inotropic drugs used in heart failure treatment. However, the specific effect of calotropin in ischemic HF (IHF) remains unknown. The objective of this study is to assess the anti-HF effect and clarify its underlying mechanisms. The left anterior descending (LAD) artery ligation on Male Sprague-Dawley (SD) rats was used to construct ischemic HF model. Daily administration of CAL at 0.05 mg/kg significantly enhanced ejection fraction (EF) and fractional shortening (FS), while inhibiting cardiac fibrosis in IHF rats. CAL reduced the OGD/R-induced H9c2 cell injury. Furthermore, CAL upregulated the expression of SERCA2a and SIRT1. The cardioprotective effect of CAL against IHF was abrogated in the presence of the SIRT1 inhibitor EX527. Notably, we identified FOXD3 as a pivotal transcription factor mediating CAL-induced SERCA2a regulation. CAL promoted the deacetylation and nuclear translocation of FOXD3 in a SIRT1-dependent manner. In conclusion, our study explores a novel mechanism of calotropin for improving cardiac dysfunction in ischemic heart failure by regulating SIRT1/FOXD3/SERCA2a pathway.
An allergy prevention method and system. The method includes retrieving, by a computing system from a fidelity card, a user profile comprising information specifying first elements known to cause a user to have an allergic reaction. The computing system retrieves data associated with an item for purchase. The data comprises information specifying second elements comprised by the item. The computing system compares the first elements to the second elements to determine that a first element of the first elements matches a second element of the second elements. The computing system generates and presents to the user, a warning indicating that the first item may cause the user to have an allergic reaction.
DNA encoding a novel human .beta.2 integrin .alpha. subunit polypeptide, designated .alpha.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which include extracellular .alpha.d protein fragments, .alpha.d I domain fragments or full length .alpha.d polypeptides and human immunoglobulin constant regions. Binding molecules specific for .alpha.d are also disclosed as useful for modulating the biological activities of .alpha.d. DNA from other species which show homology to human .alpha.d encoding sequences are also disclosed. Monoclonal antibodies immunospecific for .alpha.d are also disclosed.
Breast cancer is an ongoing issue due to its high mortality rates. Obesity enhances the problems associated with breast cancer, meaning there must be a biological connection between them. This crosstalk may be the adipose-derived stem cell. If we can interrupt the communication between adipose-derived stromal/stem cells (ASCs) and breast cancer, we may be able to prevent cancer propagation. Specific kinase inhibition may allow us to downregulate signals, preventing ASC-mediated cancer growth. This chapter provides a critical method for screening a kinase inhibitor drug library for hits on ASCs.
The invention belongs to the technical field of traditional Chinese medicines, and relates to an external health gel for treating gynecological inflammation. The external health gel is prepared from stephania, cortex phellodendri, radix sophorae flavescentis, aloe, coptis chinensis, pagodatree flower buds, polygonum aviculare, lysimachia christinae hance, peach kernel, dried alum, borneol and carbomer. The external health gel is obtained by combining summary of clinical experience for many years through repeated experiment, and has a unique curative effect on stubborn gynecological inflammation. By combined action of multiple medicines, the effective components of the medicine quickly penetrate lesions through comprehensive treatment; the lesion of the affected part is eliminated; inflammation removal is promoted; germs can be actively killed; acid and base of the vagina are balanced; and the wounds are actively repaired. The external health gel has the effects of clearing heat, expelling damp, sterilizing and relieving itching, regulating menstruation, arresting leukorrhea, lubricating the vagina, preserving the ovarian and removing the odor; the composition is appropriate and strict in compatibility; and the preparation method is unique. All raw materials are Chinese herbal medicine extracts, so that the external health gel is free of a toxic or side effect, free of sequela, fast in acting, short in treatment course, high in recovery rate and low in cost, is widely applied to vulvitis, kysthitis, cervical erosion, cervicitis and pelvic infection, and has a unique curative effect on condyloma acuminate, burns, barbiers and the like.
FIELD: medicine, pharmaceutical industry and technology. SUBSTANCE: method involves removal of mechanical pollutions from algae sacchariferous laminaria and their milling. Then laminaria homogenate is poured with 0.1 mole/l of sulfuric acid solution taken in mass-volume ratio raw : acid solution = 1:50 and extracted for 15 h at slow shaking. Then mixture is filtered, filter residue is washed out with water and filtrate is discarded. Remained algae are extracted with 1% sodium carbonate solution in the ratio raw : extracting agent = 1:50 for 12 h at stirring. Then extraction mass is treated with 1% ammonium oxalate solution in the ratio = 1:4 followed by filtration of mixture. Obtained filtrate is dialyzed across cellophane membrane for 24 h, dialyzate is evaporated, mixed with equal volume of 96% ethanol and obtained precipitate is washed out with alcohol and ether followed by its dissolving in water, mixing with equal volume of potassium chloride saturated solution and centrifugation of mixture. Liquid is separated from precipitate and equal volume of alcohol is added to its. Precipitated deposit is dissolved in water again and precipitated with alcohol once more. Precipitate is suspended in water and mixed with solution containing magnesium (II) sulfate (0.09 mole/l) and potassium chloride (0.09 mole/l) in the volume ratio suspension : saline solution = 2:1. After centrifugation of mixture supernatant is separated from precipitate, precipitate is washed out with water, precipitated with equal volume of alcohol and suspended in water. Then the following reagents are added to suspension: EDTA 0.1 mole/l solution in volume ratio = 3:1, sodium carbonate 1% solution in volume ratio = 10: 1 and sodium hydrocarbonate 1% solution in volume ratio = 10:1. After complete precipitate dissolution alginate is precipitated again with equal volume of alcohol, washed out with alcohol and ether and dried. EFFECT: enhanced purity, increased yield of end product. 10 tbl, 2 dwg
In normal pediatric patients with closed fontanelles, the contents of the central nervous system are almost compressed into the skull and spinal canal. Intracranial pressure is created and constant by the total volume of brain, CSF, and blood within the skull. Increased intracranial pressure can be measured with an intraventricular catheter, transducers, and a subarachnoid bolt. By measuring the diameter of the optic nerve sheath with ultrasonography, we can find out whether there is an increase in intracranial pressure non-invasively.

Endotracheal intubation and laryngeal mask are generally applied to secure the airway during general anesthesia. There is a widespread opinion among anesthesiologists that endotracheal intubation increases intracranial pressure. Since there were no non-invasive methods measuring intracranial pressure in the past, adequate studies on this subject could not be done. With this measurement, we aimed to show whether ETT or LMA applications have effects on intracranial pressure.
BACKGROUND: The purpose of this research is to summarize the academic expertise of Professor Lu Zhizheng in the treatment of Chronic Atrophic Gastritis, and to explain his clinical reasoning and common prescriptions in the treatment of CAG.
METHODS: Professor Lu's outpatient cases of CAG from January 2008 to December 2021 were selected, and the PageRank algorithm was applied on the FangNet platform to analyze the usage frequencies of herbs, their four natures and five flavors according to Traditional Chinese Medicine, core herbs, and herb clustering patterns, with the goal of summarizing the distinguishing features of Professor Lu's academic and clinical approach to CAG. A total of 170 patients from 252 consultations were included in this study. The prescriptions involved a total of 239 herbs, which occurred a cumulative 4339 times. The herb natures were mainly warm, neutral, and slightly cold, and the herb flavors were predominantly sweet, bitter, and pungent. The channel tropism of the selected herbs primarily targeted the spleen, stomach, and lung meridians. Herb rank analysis showed that 34 herbs, including Gancao, Taizishen, Banxia, Huanglian, Shengjiang, Baizhu, Yiyiren, Maiya, Cangzhu, and Kuxingren, were the driver herbs used by Professor Lu for the treatment of CAG.
RESULTS: Herb-herb co-occurrence/exclusivity analysis revealed 10 sets of frequently used herb pairs; herb cluster analysis yielded 10 herb clusters. These results reflected the emphasis Professor Lu placed on protecting Qi and Yin while clearing damp-heat. Professor Lu Zhizheng utilized dialectics reinforced with flexible thinking in the treatment of CAG, and emphasized that identifying the pathogenesis and addressing the syndrome should be prioritized.
CONCLUSIONS: The characteristic treatment strategy aimed to replenish Qi and nourish Yin, clear away damp-heat, and treat CAG patients comprehensively under the guidance of established principles.
The invention provides an alfalfa leaf protein moistening facial mask. The facial mask is a transparent collagen moistening facial mask and is prepared from the following components in parts by mass: 0.05-5 parts of alfalfa leaf protein serving as a functional raw material, 0.2-10 parts of sodium carboxymethylcellulose, 0.2-10 parts of humectant, 0.05-10 parts of starch and 1-20 parts of a glutaraldehyde crosslinking agent, wherein the sodium carboxymethylcellulose, humectant, starch and glutaraldehyde crosslinking agent are used as auxiliary raw materials. The preparation method comprises the following steps: firstly, extracting alfalfa leaf protein from alfalfa leaves in a fermenting manner; then mixing the alfalfa leaf protein and the auxiliary raw materials; and finally, putting the mixture in a die, heating and forming a film. The alfalfa leaf protein moistening facial mask is mainly prepared from macromolecular substances in natural animal and plant, is non-toxic and odorless, and does not have side effect. The facial mask has the effects of double moistening effect, good toughness, good ductility and good adhesion, and has functions of better skin feeling and deep skin cleaning, thus being an economical, practical and effective skin-care beautifying cosmetic. The facial mask preparation process is simple, is convenient to operate, and does not pollute the environment.
A method of treating cancerous tumors is presented herein. The method includes injecting an effective dose of a plasmid encoded for IL-12, B7-1 or IL-15 into a cancerous tumor and subsequently administering at least one high voltage, short duration pulse to the tumor. The electroporation pulses may be administered at least 700V/cm for a duration of less than 1 millisecond. The intratumor treatments with electroporation may be administered in at least a two-treatment protocol with the time between treatments being about 7 days. The intratumor treatments with electroporation may be administered in a three-treatment protocol with a time of four days between the first and second treatments and a time of three days between the second and third treatments. It was found that the intratumor treatments using electroporation not only resulted in tumor regression but also induced an immune memory response which prevented the formation of new tumors.
<P>PROBLEM TO BE SOLVED: To provide a method and a composition for targetedly delivering a medicine to only a target cell.  <P>SOLUTION: The method and the composition are directed to enhancing immune response and decreasing vaccine efficacy through simultaneous or sequential targeting of specific immune system components. The specific immune system components (such as macrophage, dendritic cells, B cells and T cells) are each individually activated by component-specific immunostimulating agents. One of such component-specific immunostimulating agents is an antigen-specific, species-specific monoclonal antibody. Additionally, the invention relates to a method which depends upon in vitro conversion of blood-derived immune cells (such as macrophage and lymphocyte) and which is for in vitro production of the antigen-specific, species-specific monoclonal antibody. The effect of vaccine is reinforced by administering a composition containing the component-specific immunostimulating agents and other elements (such as an antigen or carrier particles such as colloid methos (gold)).  <P>COPYRIGHT: (C)2010,JPO&INPIT
Inflammatory bowel diseases (IBD) play a major role in child and adolescent medicine. 25 % of patients with IBD are younger than 18 years of age at diagnosis and 25 % of those are even younger than 10 years of age at disease onset. The incidence of IBD in children and adolescents is 5-11/100 000 in Germany. IBD comprises mainly two entities, namely Crohn's disease (CD) and ulcerative colitis (UC). Patients with CD develop chronic and intermittent transmural inflammation of the gastrointestinal tract, which manifests with symptoms like diarrhea, hematochezia, abdominal pain, fatigue and malnutrition. This often results in weight loss and an increased risk of numerous complications such as the development of fistulas, perforations and intestinal strictures. In addition, growth disturbances and delayed onset of puberty are more frequent. Overall, the course of the disease can only be compared between children and adults to a very limited extent, as the disease often progresses more rapidly and severely in children. Accordingly, the procedure and recommendations for children with CD differ from those of adults. In addition to clinical scores, laboratory chemical parameters (blood count, CrP, calprotectin) and imaging diagnostics (endoscopy, ultrasound, MRT) are available to assess disease activity. However, the latter are only of limited use for routine monitoring due to their invasiveness, the need for sedation and the use of contrast agents. Multispectral Optoacoustic Tomograph (MSOT) on the other hand allows, comparable to sonography, a non-invasive, quantitative imaging of the composition of target tissues in children without sedation. Previous studies have shown that the quantitative determination of hemoglobin provides information on blood flow and inflammatory activity in the bowel of adult patients with Crohn's disease. In this pilot study, the intestinal wall of children will be characterized by MSOT to differentiate between CD, UC, and unclassified inflammatory bowel disease (U-IBD) and to quantify changes and correlate them with routine parameters. This could lead to a new possibility of non-invasive evaluation of disease forms and activity comparable to previous findings in adult patients with CD.
BACKGROUND: Perioperative corticosteroids have shown potential as nonopioid analgesic adjuncts for various orthopedic pathologies, but there is a lack of research on their use in the postoperative setting after total shoulder arthroplasty (TSA). The purpose of this study was to assess the effect of a methylprednisolone taper on a multimodal pain regimen after TSA.
METHODS: This study was a randomized controlled trial (clinicaltrials.gov NCT03661645) of opioid-naive patients undergoing TSA. Patients were randomly assigned to receive intraoperative dexamethasone only (control group) or intraoperative dexamethasone followed by a 6-day oral methylprednisolone (Medrol) taper course (treatment group). All patients received the same standardized perioperative pain management protocol. Standardized pain journal entries were used to record visual analog pain scores (VAS-pain), VAS-nausea scores, and quantity of opioid tablet consumption during the first 7 postoperative days (POD). Patients were followed for at least one year postoperatively for clinical evaluation, collection of patient-reported outcomes, and observation of complications.
RESULTS: A total of 67 patients were enrolled in the study; 32 in the control group and 35 in the treatment group. The groups had similar demographics and comorbidities. The treatment group demonstrated a reduction in mean VAS pain scores over the first 7 POD. Between POD 1 and POD 7, patients in the control group consumed an average of 17.6 oxycodone tablets while those in the treatment group consumed an average of 5.5 tablets. This equated to oral morphine equivalents of 132.1 and 41.1 for the control and treatment groups, respectively. There were fewer opioid-related side effects during the first postoperative week in the treatment group. The treatment group reported improved VAS pain scores at 2-week, 6-week, and 12-week postoperatively. There were no differences in Europe Quality of Life, shoulder subjective value (SSV), at any time point between groups, although American Shoulder and Elbow Surgeons questionnaire scores showed a slight improvement at 6-weeks in the treatment group. At mean follow-up, (control group: 23.4 months; treatment group:19.4 months), there was 1 infection in the control group and 1 postoperative cubital tunnel syndrome in the treatment group. No other complications were reported.
CONCLUSIONS: A methylprednisolone taper course shows promise in reducing acute pain and opioid consumption as part of a multimodal regimen following TSA. As a result of this study, we have included this 6-day methylprednisolone taper course in our multimodal regimen for all primary shoulder arthroplasties. We hope this trial serves as a foundation for future studies on the use of low-dose oral corticosteroids and other nonnarcotic modalities to control pain after shoulder surgeries.
People's stated preferences are often inconsistent with what matters most to them (their values). And they are often based on misconceptions, distress, and less effective cognitive coping strategies. For instance, a person might say "My goal is to have no pain" when that is not possible. Or they might say "My goal is to get the shot that fixes this" when there is no such shot. It may go without saying that people want: "To be able to live a normal lifestyle" and "To be able to accomplish most of their goals." In other words, people want to be able to be themselves. They are seeking care because they are not able to be themselves or they are concerned that they may not be able to be themselves. The word health comes from an old German word meaning "whole."

One part of good health is correcting or alleviating pathophysiology (e.g. reading glasses). Another part of good health is evolving one's inner narrative (e.g. "I'm older now and need glasses to read").

The women's health IPU at UT Health Austin is happy with having patients write down their goals at their first visit and then tracking those. It would be interesting to study people seeking musculoskeletal specialty care to determine whether asking patients what result of their care would be rated a success helps direct the clinician-patient interaction in a more fruitful direction compared to the usual clinical interaction.