anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Weekly sessions of e-CBT through OPTT will consist of approximately 30 slides. Each session is expected to last approximately 50 minutes. The content and format of each weekly online session were designed to mirror live CBT. The slides will highlight a different topic each week and include general information, an overview of skills and homework on that topic. The homework included in each session will be submitted through OPTT and reviewed by the clinicians with personalized feedback provided by clinicians within three days of submission. Weekly homework submission for feedback will be mandatory before being eligible for the next session. Biweekly GAD-7, DASS-42 and Q-LES-SF questionnaires will be completed through OPTT. A second STAI will be completed in the final week of e-CBT treatment.
The invention discloses a method for treating cancer by combining graphene, relates to the technical field of cancer treatment, and S1 is used for carrying out combined treatment of graphene-based materials and chemotherapy on a patient, and comprises the step of preparing a composite nano-drug loaded with an anti-cancer drug. S2, preparing the tumor targeting photothermal response nano-delivery carrier capable of controllably releasing the drug. S3, preparing the intravenous injection preparation. And S4, carrying out infrared radiation heating on the graphene heating element for the patient. S5, combining the photo-thermal conversion of the graphene under the laser with the wavelength of 808nm to realize the effect of the PTT synergistic SDT for enhancing the anticancer effect. The invention utilizes the temperature difference between the malignant tumor tissue and the normal tissue, combines PTT to cooperate with SDT to ensure that the tumor cells are heated to be lethal, and the normal tissue is not damaged, thereby achieving the purpose of treating cancer.
In the 21st century, nephrologists in the United States face many challenges including a forecast of decline in physician manpower. Challenges that are specific to hemodialysis (HD) include reimbursement constraints, a growing shortage of nurses and major technological advances in dialysis equipment. There is a growing interest in alternative dialysis regimen and frequency, but a lack of patient incentive for self-care dialysis either in the center or in the home setting. The proposed phase 4 post-marketing study plans to explore whether daily HD is economically attractive compared with thrice weekly HD, while improving health-related quality of life and other dialysis adequacy measures. This project is unique as it provides a large prospective cohort of patients converted to daily HD, with a longitudinal follow up and an ability to compare to a matched cohort from the United States Renal Data Services. This study will help develop whether daily dialysis is economically attractive through the use of new technologies that reduce treatment costs and decrease hospitalization rates, with the long-term hope of increasing life expectancy. All patients will have the option to participate in the Quotidian Dialysis Registry, coordinated by the Lawson Health Research Institute (LHRI) in London, Ontario.
1418605 Hair waving and crease proofing composition SHISEIDO CO LTD 1 May 1974 [4 May 1973] 19165/74 Heading D1P A composition for waving hair or permanently creasing wool or other keratinous fibre material comprises a sulphite or bisulphite main waving agent and an accelerator which is either an alkylene carbonate where R 1 , R 2 , R 3  and R 4  are each hydrogen, methyl, ethyl, hydroxymethyl or hydroxyethyl; or a γ- or 8-lactone where R 1 , R 3  and R 5  are each a hydrogen or methyl. Specified waving agents are the sulphite and bisulphites of lithium, sodium, ammonium and mono-, di- and tri-ethanolamine and propanol amine. Specified accelerators are ethylene propylene and butylene carbonate, y butyralactone, 2-methyl-γ-butyrolactone, 3-methyl-γ- butyrolactone, 4-methyl-γ-butyrolactone, 8- valerolactone, 2, 5-dimethyl-#-valerolactone and #-caprolactone. Mixtures of accelerators may be used. The composition is preferably a homogenous aqueous solution comprising 1 to 40% waving agent 5 to 70% accelerator and optionally ethanol or propanol as a solubilizer, polyethylene glycol or glycerin as a humectant and an acrylic resin as a thickening agent. Its pH is preferably 6 to 9 i.e. close to that of human skin. It is applied at room temperature for e.g. 10 minutes. It may then be removed by rinsing with water or by the application of a water soluble barium or calcium salt of chloride, bromide, iodide, formate, acetate or hydroxybenzoate. Removal by means of a barium or calcium salt accelerates the reformation of cystine linkages.
PURPOSE:To obtain a hair growth promoting cosmetic having high safety and water-solubility, comprising an extract having specific properties prepared by extracting a trepang or its dried material with an aqueous medium. CONSTITUTION:A hair growth promoting cosmetic comprises an extract prepared by extracting a prepang such as Stichopus japonicus, Stichopus chloronotus, Holothuria Leucospilota as it is or its dried finely cut material (especially its lip part) with an aqueous medium. The properties of the extract. (1): A blackish brown pasty substance having a slightly fish-like smell. (2): Soluble in water and a diluted alcohol, becoming slightly muddy and being soluble in an alcohol, insoluble in ether, chloroform, benzene, toluene, xylene, petroleum ether and petroleum benzine. (3) 1% aqueous solution has pH6.2-6.5. (4) Positive in xanthoprotein reaction and Liebermann reaction. (5) When 1% aqueous solution is subjected to thin film chromatography under a specific condition, the solution produces a spot which is initially colored in reddish purple at a position of 0.3-0.4 Rf value and changes to brown. The amount of the extract of trepang added is preferably 0.3-2wt.%.
The intervention will comprise of 24 weeks of twice weekly supervised exercise sessions, emphasising aerobic exercise. To reflect a real-world setting, each group will experience both aerobic and resistance exercise, but there will be a 75%:25% predominant: subsidiary mode emphasis based on exercise duration within each session.
Cervical cancer is highly preventable through vaccination, early detection, and treatment, yet is the fourth most common cancer globally. HPV testing is superior to cytology for the detection of cervical pre-cancer, and jurisdictions around the world are implementing HPV primary screening, which offers the opportunity for self-screening, an important self-care intervention. Digital health solutions are also increasingly important components of self-care. In this study, we assessed the acceptability and completion of self-screening for cervical cancer offered through a digital platform within a low screening uptake region of British Columbia. The primary objective of this study was to evaluate the acceptability of self-screening for cervical cancer offered through a digital platform as measured by return rates of self-screening kits. Patients due or overdue for cervix screening were invited to participate. Eligible participants registered online to receive a self-screening kit, which included a device for vaginal self-screening, instructions, and a return envelope, sent to their home. After self-screening using the vaginal device, HPV testing was conducted. HPV-negative participants were returned to routine screening, and HPV-positive participants were recommended for cytology or colposcopy. Attendance rates at follow-up were evaluated. Participants were invited to complete an acceptability survey. From April 2019 to December 2023, 283 participants were sent kits, with 207 kits returned for a completion rate of 73%. Of valid samples (n = 202), 15 were HPV positive, and 93% attended follow-up care. Most respondents found the CervixCheck website easy to use, informative, and secure and were satisfied with receiving their results online. CervixCheck had a high completion rate among participants who were sent a self-screening kit. High compliance with recommended follow-up and high acceptability of self-screening for cervical cancer was observed. Most participants indicated they would self-screen again in the future. Innovative approaches to cervical screening, including self-screening and the use of digital health interventions, are ways to enhance equity and improve uptake of cervical screening.
The Aegilops tauschii resistant accession prevented the pathogen colonization by controlling the sugar flow and triggering the hypersensitive reaction. This study suggested that NBS-LRRs probably induce resistance through bHLH by controlling JA- and SA-dependent pathways. Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst) is one of wheat's most destructive fungal diseases that causes a severe yield reduction worldwide. The most effective and economically-friendly strategy to manage this disease is genetic resistance which can be achieved through deploying new and effective resistance genes. Aegilops tauschii, due to its small genome and co-evolution with Pst, can provide detailed information about underlying resistance mechanisms. Hence, we used RNA-sequencing approach to identify the transcriptome variations of two contrasting resistant and susceptible Ae. tauschii accessions in interaction with Pst and differentially expressed genes (DEGs) for resistance to stripe rust. Gene ontology, pathway analysis, and search for functional domains, transcription regulators, resistance genes, and protein-protein interactions were used to interpret the results. The genes encoding NBS-LRR, CC-NBS-kinase, and phenylalanine ammonia-lyase, basic helix-loop-helix (bHLH)-, basic-leucine zipper (bZIP)-, APETALA2 (AP2)-, auxin response factor (ARF)-, GATA-, and LSD-like transcription factors were up-regulated exclusively in the resistant accession. The key genes involved in response to salicylic acid, amino sugar and nucleotide sugar metabolism, and hypersensitive response contributed to plant defense against stripe rust. The activation of jasmonic acid biosynthesis and starch and sucrose metabolism pathways under Pst infection in the susceptible accession explained the colonization of the host. Overall, this study can fill the gaps in the literature on host-pathogen interaction and enrich the Ae. tauschii transcriptome sequence information. It also suggests candidate genes that could guide future breeding programs attempting to develop rust-resistant cultivars.
This study explored the extent of menstrual manipulation and its associated impact on period-related symptoms and training disruptions in Australian Female Cyclists. 205 female cyclists, from recreational to elite level, participated in an online "Female Cyclist Questionnaire (FCQ)". The FCQ utilised a series of validated questionnaires to obtain demographic information and menstrual function of the respondents, and to investigate their menstrual manipulation habits and perceptions on how their period-related symptoms affected their well-being, mood, energy and training tolerance. More than 80% of the cyclists reported that their period-related symptoms impacted upon training and 41% made training adjustments based on these symptoms. Two-thirds of respondents thought their training should be phase-controlled yet only half discussed their hormonal cycles with their coaches. Menstrual manipulation was predicted by reduced "workout tolerance" in these cyclists (odds ratio = 0.632). Half of the respondents reported compromised ability to tolerate high-intensity interval training with period-related symptoms. Period pain, increased irritability, lower energy levels and more sugar cravings were commonly reported but did not predict menstrual manipulation. The data indicated that period-related symptoms are present in Australian female cyclists across all levels of participation. However, the perceived impact to training and subsequent behavioural changes varied among individuals.
AIM: To identify the factors associated with thrombosis in dialysis patients.
BACKGROUND: Thrombosis is a leading cause of vascular access failure in dialysis patients. Numerous risk factors contribute to thrombosis in this population.
METHODS: A systematic search was conducted across international databases using standardized keywords. The quality of the selected studies was assessed using the STROBE and CONSORT checklists. The findings were summarized in a Garrard table. Meta-analysis was performed using CMA software. The study adhered to the guidelines outlined in the PRISMA statement.
RESULTS: A total of 180 articles were reviewed. The odds ratio for thrombosis in patients with arteriovenous grafts compared to arteriovenous fistulas was 10.93 (95 % CI: 9.35-12.78), demonstrating statistical significance (P = 0.001). Similarly, hemodialysis patients had an odds ratio of thrombosis 3.60 times higher than non-hemodialysis patients (95 % CI: 3.54-4.19), with statistical significance (P = 0.001). Patients undergoing single-stage basilic vein transposition had a 1.89 times higher risk of thrombosis compared to those undergoing two-stage transposition (95 % CI: 1.04-3.46), also demonstrating statistical significance (P = 0.038).
CONCLUSIONS: Thrombosis in patients with end-stage renal disease undergoing dialysis was significantly associated with various factors, including graft access, single-stage basilic vein transposition, and hemodialysis. Additional contributing factors to thrombosis included diabetes, elevated homocysteine levels, female gender, age over 50, access location, and low access blood flow velocity. The analysis revealed a higher incidence of thrombosis in end-stage renal disease patients undergoing hemodialysis compared to those not undergoing dialysis, as well as in patients with arteriovenous grafts compared to those with arteriovenous fistulas. These findings underscore the importance of recognizing and managing these risk factors to prevent thrombotic events and enhance patient care within the dialysis setting.
BACKGROUND & AIMS: The key step of the Global Leadership Initiative on Malnutrition (GLIM) is nutritional risk screening, while the most appropriate screening tool for colorectal cancer (CRC) patients is yet unknown. The GLIM diagnosis relies on weight loss information, and bias or even failure to recall patients' historical weight can cause misestimates of malnutrition. We aimed to compare the suitability of several screening tools in GLIM diagnosis, and establish machine learning (ML) models to predict malnutrition in CRC patients without weight loss information.
METHODS: This multicenter cohort study enrolled 4487 CRC patients. The capability of GLIM diagnoses combined with four screening tools in predicting survival probability was compared by Kaplan-Meier curves, and the most accurate one was selected as the malnutrition reference standard. Participants were randomly assigned to a training cohort (n = 3365) and a validation cohort (n = 1122). Several ML approaches were adopted to establish models for predicting malnutrition without weight loss data. We estimated feature importance and reserved the top 30% of variables for retraining simplified models. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity were calculated to assess and compare model performance.
RESULTS: NRS-2002 was the most suitable screening tool for GLIM diagnosis in CRC patients, with the highest hazard ratio (1.59; 95% CI, 1.43-1.77). A total of 2076 (46.3%) patients were malnourished diagnosed by GLIM combined with NRS-2002. The simplified random forest (RF) model outperformed other models with an AUC of 0.830 (95% CI, 0.805-0.854), and accuracy, sensitivity and specificity were 0.775, 0.835 and 0.742, respectively. We deployed an online application based on the simplified RF model to accurately estimate malnutrition probability in CRC patients without weight loss information (https://zzuwtt1998.shinyapps.io/dynnomapp/).
CONCLUSIONS: Nutrition Risk Screening 2002 was the optimal initial nutritional risk screening tool in the GLIM process. The RF model outperformed other models, and an online prediction tool was developed to properly identify patients at high risk of malnutrition.
BACKGROUND: Several studies have suggested a potential correlation between menopause and airflow limitation. However, the presence of protective factors in postmenopausal women remains uncertain. Therefore, our study seeks to examine potential protective factors associated with a reduced prevalence of airflow limitation among postmenopausal women.
METHODS: Postmenopausal women were recruited from the Taiwan Biobank for this cross-sectional study. Airflow limitation was defined by a forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) ratio <0.7. The participants were categorized into two groups: non-coffee drinkers and coffee drinkers, and the association between coffee consumption and airflow limitation was examined using binary logistic regression models.
RESULTS: A total of 8149 women with available information were enrolled. Compared to the non-coffee drinkers, the coffee drinkers had a significantly lower prevalence of airflow limitation (7% vs. 5%). The odds ratio (OR) for airflow limitation was lower in the coffee drinkers than in the non-coffee drinkers (OR = 0.77; 95% confidence interval [CI] = 0.63 to 0.94) after adjusting for confounding factors. We also examined the association between daily coffee consumption in cups and airflow limitation. The women who consumed ≥2 cups of coffee per day had an OR of 0.74 (95% CI = 0.59 to 0.94) compared to those who did not consume coffee.
CONCLUSIONS: Our results suggest that habitual coffee consumption is associated with a reduction in the prevalence of airflow limitation in postmenopausal women, warranting further prospective studies to explore possible causal effects and mechanisms.
In the control group, patients just diuretic adjusted (Furosemide 40 milligrams) by the doctor on the baseline. The patients do not receive phone calls neither advising on non-pharmacological treatment; The medication is adjusted by the doctor during the initial evaluation of study baseline.
Patients with major depressive disorder. These patients consisted of two cohorts. The first cohort is expected to consist of 15 participants for nested cohort study. The rest form the second cohort.
A subject-specific simulation model of at least one component in the cardiovascular system for simulating blood flow and/or structural features. This simulation model can be used as a tool for cardiovascular diagnostic and/or treatment planning. The invention also regards non-invasive medical imaging of the cardiovascular system. The simulation model of a component in the cardiovascular system, for instance a pumping heart, is reconstructed by combining computational fluid dynamics (CFD) and/or fluid structure interaction (FSI) algorithms with medical imaging, such as for example ultrasound, MRI or CT. Such models make it possible to describe the complex flow phenomenon and provide flow details. The subject-specific model is a tool for clinical decision-making, an objective support for health care professionals in making decisions prior to surgery.
LY2835219 administered orally. Tamoxifen administered orally. This arm is closed to enrollment.
The product has a structure (I): R1 -(O-CO)-R2 (I) (where R1 is a polymer contg. vinylene carbonate units and R2 is a protein). The products are for use in chemical reaction and medical treatments involving enzymes e.g. the treatment of blood with L-asparaginase or the degradation of starch. The polymer support may be prepd. by standard methods involving the polymerisation of vinylene carbonate or the introduction of vinylene carbonate into other polymer structures. The products are prepd. by mixing a soln of the protein in buffer with the solid polymer.
Participants in this study arm will not have access to the OurPlan program in the app from baseline to day 30 (month 1) of the trial. From day 31 to day 60, participants in this study arm will be given access to the OurPlan program in the app.
After the surgery is performed, study participants will stop taking telotristat ethyl (Xermelo®) as part of this study and there will be no follow-up visits or calls required outside of the usual postoperative care. The research team will collect clinical data on the participants' outcomes up to 30 days after surgery by accessing medical records.
* Octreotide acetate for injectable suspension should be administered by a trained healthcare provider. It is important to closely follow the mixing instructions included in the packaging. Octreotide acetate for injectable suspension must be administered immediately after mixing.
  * Do not directly inject diluent without preparing suspension.
  * The recommended needle size for administration of octreotide acetate for injectable suspension is the 1½” 19 gauge safety injection needle (supplied in the drug product kit). For patients with a greater skin to muscle depth, a size 2” 19 gauge needle (not supplied) may be used.
  * Octreotide acetate for injectable suspension should be administered intramuscularly (IM) in the gluteal region at 4-week intervals. Administration of octreotide acetate for injectable suspension at intervals greater than 4 weeks is not recommended.
  * Injection sites should be rotated in a systematic manner to avoid irritation. Deltoid injections should be avoided due to significant discomfort at the injection site when given in that area.
  * Octreotide acetate for injectable suspension should never be administered intravenously or subcutaneously.



The following dosage regimens are recommended.
PROBLEM TO BE SOLVED: To obtain a new compound acting as an inhibitor against sodium- dependent bicarbonate/chloride (hydrochloride) exchangers or sodium/bicarbonate symporters and useful for the treatment or prevention of diseases developing according to ischemic status, damaged respiratory impulse, myocardial infarction, stenocardia, and the like. SOLUTION: This new compound is shown by formula I (R1 is H or the like; or R1 and R3 form, together with a carbon atom which has bound them, a 3-7C cycloalkyl or the like; R2 to R5 are each H or the like; R6 and R7 are each H or the like), e.g. 4'-cyclohexylidenemethylbiphenyl-2-sulfonyl cyanamide. The compound of formula I is obtained by reaction of a compound of formula II (e.g. 4'-cyclohexylidenemethylbiphenyl-2-sulfonamide) with cyanogen bromide in a dipolar aprotic solvent stable to cyanogen bromide such as acetonitrile using a strong auxiliary base which is not so highly nucleophilic such as K2 CO3 pref. at 60-120 deg.C.
A multifunctional polypeptide chain or a protein. A polypeptide chain X, comprising an antigen 1 binding domain R1, an auxiliary peptide chain linking domain R2 and an antigen 2 binding domain R3. The auxiliary peptide chain linking domain R2 is a cytokine or a cytokine binding domain in a cytokine receptor. A protein, which is a heterodimer composed of the polypeptide chain X as a main peptide chain and an auxiliary peptide chain Y. The auxiliary peptide chain Y comprises an antigen 3 binding domain R4 and a main peptide chain X linking domain R5, or the auxiliary peptide chain Y is the main peptide chain linking domain R5. The multifunctional protein mediates specific cell killing by binding to different tumor antigens with the two antigen binding domains of tumor-associated antigens therein. The multifunctional protein can function as a cytokine by introducing a cytokine or a cytokine receptor complex.