anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A pharmaceutical composition containing a Selaginella tamariscina spring extract or a fraction thereof is provided to prevent or treat atopic dermatitis. CONSTITUTION: A pharmaceutical composition for preventing or treating atopic dermatitis contains a Selaginella tamariscina spring extract or a fraction thereof and a pharmaceutically acceptable carrier. The extract is prepared using water, C1-C4 alcohol, or a mixture thereof. The C1-C4 alcohol is methanol or ethanol. The fraction is prepared using a non-polar or polar organic solvent. [Reference numerals] (AA) Times; (BB) Control group; (CC) Experimental group 1; (DD) Experimental group 2; (EE) Experimental group 3; (FF) Time(minutes)
Non-alcoholic fatty liver disease (NAFLD) is the most common liver ailment in developed countries. Fatty liver - steatosis - affects up to one third of the population. Its prevalence is rising and seems to parallel the global increase in obesity and type-2 diabetes. The etiology of NAFLD in humans is not well understood. We propose that the hepatic conversion of carbohydrates (CHO) to lipids (de novo lipogenesis, DNL) is a key factor in the accumulation of excess liver fat and the accompanying dyslipidemia and hepatic insulin resistance; and that suppressing DNL by diet will reduce liver fat and improve both lipid and carbohydrate metabolism in patients with steatosis. These hypotheses are based on studies in which we and others have established that fractional hepatic DNL can vary dramatically depending on the diet and/or health status of a subject; and, in particular, that dietary fructose is a potent lipogenic stimulus. In this proposal we will perform CRC-based studies to compare the rates of DNL and very low density lipoprotein (VLDL) kinetics in steatotic and matched non-steatotic controls and evaluate their relationship to lipid profiles and hepatic and whole-body insulin resistance and overall carbohydrate metabolism (Aim1). The steatotic individuals whose habitual intake of fructose and other simple sugars exceeds 15% of total energy intake will then be randomized to consume one of two low-fat diets that differ only in CHO type to determine whether diet-induced changes in DNL affect liver fat flux and content and hepatic, whole-body insulin sensitivity, and overall carbohydrate metabolism (Aim 2). We hypothesize that a diet that is rich in complex CHO will achieve greater decreases in DNL and liver fat than one that contains typical amounts of simple CHO, including fructose. This dietary intervention study includes a 6-week 25% energy restriction outpatient phase to promote moderate weight loss and improve insulin sensitivity, followed by a two weeks weight maintenance with the last 4 days as an inpatient stay during which all of the studies performed at baseline (Aim 1) will be repeated. State-of-the-art stable isotope techniques will be used to assess hepatic DNL, apoB100 turnover, VLDL-triglyceride (TG) fluxes, and lipolysis under fasting and fed conditions. Hepatic and extra-hepatic insulin sensitivity will be measured using hyperinsulinemic-euglycemic clamps and stable isotope studies of endogenous glucose production and glycogen flux. Liver and muscle fat will be measured by proton magnetic resonance spectroscopy (MRS), visceral fat by magnetic resonance imaging (MRI), and whole-body composition by dual-energy X-ray absorptiometry (DEXA). These studies will allow us to evaluate the importance of DNL as a mechanism modulating liver fat content and flux, and the significance of CHO quality in dietary guidance for steatotic patients.
PURPOSE:An external preparation for skin that is obtained by combining PEG with polysulfides and adjusting the pH to a certain value, thus showing high stability with the passage of time and showing better therapeutic effect against acnes than the conventional powdery sulfur. CONSTITUTION:Polysulfides M2SX (M: alkali metal, ammonium, alkaline earth metal; X is 2-6) are combined with PEG and the pH of the system is adjusted to 9-12 to give an external preparation for skin with high stability. The PEG is, e.g., PEG 200, 300, 400, 600 and is preferably liquid at room temperaure. The examples of the polysulfides are sodium disulfide, potassium disulfide, or ammonium pentasulfide. The amound of the polysulfide is preferably 0.5-7wt%. It has high action of keratin release and shows good therapeutic effect for acne.
Participants receive gemcitabine hydrochloride IV over 30 minutes on day 1, cisplatin IV on days 1 and 2, and pegfilgrastim SC on day 3. Treatment repeats every 14 days for up to 6 courses in the absence of disease progression or unaccepted toxicity. Participants with DDR gene alteration and disease stage \>= cT1 or participants without DDR gene alteration undergo radical cystectomy or chemoradiotherapy.
Functional nausea patients with a score of 7-9 on the BARF (BAxter Retching Faces) scale will be given questionnaires and testing by EGG and/or MGG after an overnight fast to determine nausea parameters. They will also have a EKG and do some testing after being fed a protein bar. Some patients will also be tested after receiving a one time dose of a 4mg or 8mg dependent upon age disintegrating tablet of ondansetron followed by a 2 day washout period prior to testing again after a 5 day maintenance dose of oral cyproheptadine 4mg twice a day.
Approximately 70% of thoracic surgery patients are pre-frail or frail, characterized by reduced strength, endurance, and physiologic function. Frailty is associated with poor perioperative outcomes, including increased complications, length of stay, post-discharge institutionalization, healthcare costs, and mortality. As a result, surgical and geriatric clinical societies now recommend including a frailty assessment in older adult pre-operative surgical evaluations. To mitigate the risks associated with frailty, prehabilitation (prehab) has been included as a component of the American College of Surgeons "Strong for Surgery" quality initiative. Evidence-based practices to optimize preoperative health have been shown to improve physical conditioning and return to autonomy, as well as, reduce length of stay, postoperative complications, and healthcare costs. Older patients who need surgery view prehab favorably, particularly if it is home-based, recommended by a medical professional, and free. The primary objective will be to conduct a feasibility evaluation using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. The secondary objectives will be to measure functional status and clinical outcomes longitudinally in patients undergoing prehab.

Participants will receive the prehab program from 2-12 weeks prior to undergoing elective inpatient thoracic surgery. Participants will complete surveys at 2-3 weeks, 2 months, 3-4 months, and 6 months after surgery.
Telemedicine group need to complete sleep-related questionnaires on the Redcap website. Participants in the telemedicine group will learn Home sleep apnea testing(HSAT) online and then complete overnight monitoring at home. Patients diagnosed with OSA after HSAT monitoring will receive standardized APAP treatment. At 1 month of APAP treatment, participants in the telemedicine group will be followed up by phone/video to check their APAP treatment compliance and prompted to complete the corresponding follow-up questionnaire on the Redcap website. After 3 months of APAP treatment, the telemedicine group will be followed up by phone/video to check their APAP treatment compliance at 3 month, and they will finish corresponding follow-up questionnaires on Redcap website. 24-hour ambulatory blood pressure monitoring, and physical measurements will be conducted in sleep center at 1 month and 3 month.
BACKGROUND: Pediatric patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) face several risk factors influencing transplantation success, including nutritional status as measured by body mass index (BMI).
METHODS: This study analyzed BMI data collected from patients transplanted between 2003 and 2023, and aimed to evaluate whether deviations from normal BMI are associated with poorer clinical outcomes. BMI levels assessed before and after first-line treatment and pre-transplantation were analyzed retrospectively to determine a correlation with survival and post-transplant complications.
RESULTS: Underweight patients had significantly lower 12- and 36-month overall survival rates compared to normal-weight and overweight patients (p = 1.22 × 10-8 and p = 8.88 × 10-8, respectively). Event-free survival was also lower for underweight patients at all time points. A higher pre-transplant BMI increases the risk of acute graft-versus-host disease (GVHD, p = 0.00068). Otherwise, pre-transplant BMI was not significantly correlated with early TRCs and cGVHD. As secondary objectives, this study identified differences in BMI across primary disease groups, with solid tumor patients having the highest BMI and myelodysplastic syndrome patients having the lowest. BMI cut-offs were identified to predict or protect against serious outcomes, including delayed engraftment, TRCs, and acute and chronic GVHD.
CONCLUSIONS: This study highlights the importance of nutritional assessment and management in pediatric patients undergoing allo-HSCT to optimize post-transplant outcomes, as deviations from a normal BMI can significantly impact post-transplant health. These findings underscore the importance of integrating BMI assessment throughout the entire pre-HSCT therapeutic course to identify patients at higher risk for complications and to define more effective nutritional management strategies.
We present the case of a woman in her 60s with Child-Pugh C cirrhosis who developed pericardial tamponade during an admission for a haemothorax secondary to a mechanical fall. The patient developed haemodynamic compromise with a rapid decline in renal function. During an open subxiphoid drain tube insertion, a pre-existing peritoneopericardial communication was noted, with ascites in the peritoneal cavity on view. The serum ascites albumin gradient was 14 g/L. Maximal medical therapy was commenced including diuresis and albumin, with adjunctive terlipressin infusion which restored her baseline renal function and resolved the effusion. We believe this is the first case report of using open drainage, maximal medical therapy and terlipressin to successfully treat hepatic hydropericardium and its subsequent renal compromise.
Diabetic calcific tendinopathy is the leading cause of chronic pain, mobility restriction, and tendon rupture in patients with diabetes. Tendon stem/progenitor cells (TSPCs) have been implicated in the development of diabetic calcified tendinopathy, but the molecular mechanisms remain unclear. This study found that diabetic tendons have a hyperoxic environment, characterized by increased oxygen delivery channels and carriers. In hyperoxic environment, TSPCs showed enhanced osteogenic differentiation and increased levels of reactive oxygen species (ROS). Additionally, hypoxia-inducible factor-1a (HIF-1a), a protein involved in regulating cellular responses to hyperoxia, was decreased in TSPCs by the ubiquitin-proteasome system. By intervening with antioxidant N-acetyl-L-cysteine (NAC) and overexpressing HIF-1a, we discovered that blocking the ROS/HIF-1a signalling axis significantly inhibited the osteogenic differentiation ability of TSPCs. Animal experiments further confirmed that hyperoxic environment could cause calcification in the Achilles tendon tissue of rats, while NAC intervention prevented calcification. These findings demonstrate that hyperoxia in diabetic tendons promotes osteogenic differentiation of TSPCs through the ROS/HIF-1a signalling axis. This study provides a new theoretical basis and research target for preventing and treating diabetic calcified tendinopathy.
Pain is a biopsychosocial term that comprises sensory, cognitive, and emotional factors. The biological, psychological, and cognitive aspects of pain are all present. Pain symptoms and comorbid symptoms are biological characteristics; anxiety, depression, and rage are psychological characteristics; and the ability to cope, catastrophize, and manage pain are cognitive characteristics. As a result, pain is influenced by a person's past experiences and beliefs. Pain that lasts longer than three months is referred to as chronic pain. A major issue is the high prevalence of chronic pain in children. Children with chronic pain have a lower quality of life than their healthy peers. Furthermore, this effect is unrelated to the degree of biological damage. Some children are more sensitive to pain than others, regardless of the severity of the condition. Because psychological, cognitive, and social variables influence an individual's perception of pain in addition to biological tissue damage.

The use of coping techniques in children varies based on the diagnosis, age, and gender of the child, according to the literature. Inadequate coping techniques are linked to a lower quality of life and increased pain severity. As a result, pain assessment in children with chronic pain should be done within a biopsychosocial framework. Various assessments have been developed to assess children's pain tolerating abilities. The Pain Coping Questionnaire (PCQ) was created to evaluate problem-focused, emotional-focused, and avoidance-focused coping strategies in children. It's the most commonly used scale for assessing children's coping techniques. The purpose of this study is to show that the Turkish version of the Pain Coping Questionnaire is valid and reliable (PCQ).
Extracts from certain Mexican indian medicinal plants used in traditional indigenous medicine for the treatment of inflammations contain sesquiterpene lactones (SLs), which specifically inhibit the transcription factor NF-λB (1). Here we show that SLs prevented the activation of NF-λB by different stimuli such as phorbolesters, tumor necrosis factor (TNF)-α, ligation of the T-cell receptor and hydrogen peroxide in various cell types. Treatment of cells with SLs prevented the induced degradation of IλB-α and IλB-β by all these stimuli, suggesting that they interfere with a rather common step in the activation of NF-λB. SLs did neither interfere with DNA-binding activity of a ctivated NF-λB nor with the activity of the protein tyrosine kinases p59fyn and p60src. Micromolar amounts of SLs prevented the induced expression of the NF-λB target gene ICAM-1. Inhibition of NF-λB by SLs resulted in an enchanced cell-killing of murine fibroblast cells by TNF-α. SLs lacking an exomethylene group in conjugation with the lacone function displayed no inhibitory activity on NF-λB. The analysis of the cellular redox-state by FACS showed that the SLs had no direct or indirect anti-oxidant properties.
Isolation of a plasminogen activator comprises (a) selective adsorption of the activator on a support having specific affinity for it and formed of soluble fibrin fragments covalently joined to an insoluble matrix; and (b) elution of the activator from the support. The prefd. insoluble matrix is a dextran polymer activated by cyanogen bromide or a porous glass e.g. aminated porous silica.. The activator is used for treatment of thromboses. This is an improved method compared with that of FR applications 73-042981 (Derwent 27490W/17) and 75-013932 (Derwent 84971X/46). It allows large scale production of the activator using less complex (fewer stages) prodn. methods, and gives a prod. having excellent purity. 20-50 million units are isolated from 100 kg of fresh animal organs; and the product has activity of 15,000-20,000 units per mg of protein.
The present invention relates to the field of cosmetics. Aiming at providing an antioxidant moistening lipstick containing medlar pigment and seabuckthorn oil and having the functions of moistening and resisting oxidation for lips and a preparation method thereof, the lipstick comprises the following raw materials in parts by weight: 0.5 part of medlar pigment, 3 parts of seabuckthorn oil, 6 parts of calendula essential oil and 4 parts of beeswax. All components in the lipstick are natural products and are non-toxic. The fructus Lycii pigment has antioxidant effect, and can also be used as red pigment. The seabuckthorn oil is used as main moistening oil, the calendula oil is used as auxiliary moistening oil, and the three are mixed to realize good moistening and oxidation resisting effects. The invention is especially suitable for dry and strong ultraviolet areas.
Allergic rhinitis (AR) affects 23-30% of the European population and is associated with a major burden on public health. AR and asthma frequently coexist, and may both be caused by allergen exposure. While the efficacy of AIT, i.e. reduce symptoms and medication use in patients with AR and asthma, has been demonstrated in several randomized clinical trials, little is known about the use and effectiveness of AIT in real world clinical practice.

This study is a retrospective database study that uses real-world data from Germany. The study population consists of AR patients with and without asthma treated with AIT and matched controls not treated with AIT. Information about the patients and treatments will be obtained from the 'BKK German Sickness Fund Database' from 2007 until 2017.
Due to a high incidence of 9/1000 live births, congenital heart disease (CHD) is a public health problem, A substantial percentage of infants and toddlers with CHD undergo cardiopulmonary bypass surgery. Undernutrition affects up to 90% of these patients, and it's contributed to worse surgical and neurological outcomes. Infants with CHD are typically delivered at full term with a normal birth weight. However, as time passes, their development may become stunted. There are no negotiated guidelines for nutritional monitoring and intervention in this age bracket of infants. Through the use of Energy Enriched and Protein Enriched nutrition formula during the postoperative phase, this has shown to be well tolerated and support in delivering higher nutrition intakes within the first days after surgery. Numerous clinical trials have been conducted (Zhang H et al., 2018; Scheeffer. et al., 2019) and were designed to explore the effects of early introduction of Energy Enriched and Protein Enriched formula (EP) to infants with CHD. The research found that feeding EP is correlated with improved weight gain and nutritional status, and also a decrease in Hospital Length Of Stay (HLOS) as well as antibiotic use, but this also causes increased feeding discomfort. The signs of feeding discomfort, on the other hand, were improved by medication and had little effect on feeding progress.

The objective of this research is to assess the long term outcome of patients who have had energy- and protein-rich nutrition formulas post cardiac surgery.
The risk of recurrence in patients with muscle invasive bladder cancer (MIBC) after radical cystectomy depends on the pathological tumor stage. In particular, patients with lymph node metastasis (pN+), locally advanced (≥pT3), or residual muscle invasive tumor despite neoadjuvant chemotherapy are at high risk. Currently, the importance of adjuvant therapy with immune checkpoint inhibitors is increasing in the context of perioperative systemic therapeutic concepts. The indication for the PD‑1 inhibitor nivolumab currently approved in the European Union requires testing of PD-L1 (programmed cell death ligand 1) protein expression by immunochemistry in tumor tissue. Focusing on MIBC patients at high risk of recurrence, new questions arise regarding the implementation and interpretation of PD-L1 testing. An interdisciplinary group of experts from Germany has discussed relevant issues from a clinicopathological point of view and developed practical recommendations to facilitate the implementation of validated and quality-assured PD-L1 testing for the approved indications in daily clinical practice.
Lidocaine (local anesthetic) associated with dexamethasone (corticosteroid) will be administered by iontophoresis technique. Dose per session and iontophoresis: 10 minutes with an intensity of 4 mA.
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. Previously, it has been demonstrated that superpositively charged proteins are efficiently endocytosed and can bring associated proteins and nucleic acids into cells. The vast majority of cargo delivered in this manner, however, remains in endosomes and does not reach the cytosol. The present invention provides endosomal escape peptides that enhance endosomal escape and cytosolic delivery of proteins and other agents of interest. In one aspect, described herein are novel fusion proteins comprising endosomal escape peptides fused to proteins and other agents of interest for delivery to a cell. Also provided herein are methods and compounds useful in preparing the fusion proteins, as well as pharmaceutical compositions and uses of the fusion proteins.
The present invention relates to a kind of fragrance wine and its production method, belong to food processing technology field.The production method of the fragrance wine of the present invention comprises the following steps：A. rose, sweet osmanthus, feverfew, radix glycyrrhizae are milled, obtain mixed powder；B. mixed powder and sorghum, glutinous rice, matrimony vine and banana are mixed, 121~135 DEG C of 60~120min of processing, obtains fragrance of a flower slurry；C. cellulase, 45~55 DEG C of 20~30min of processing are added in fragrance of a flower slurry；D. 25~35 DEG C are cooled to, adds the saccharomyces cerevisiae equivalent to 0.4~1wt% of fragrance of a flower slurry gross weight, fills altar, sealing, 28~35 DEG C of insulations, spontaneous fermentation 9~15 days；E. the wine liquid fermented is distilled and produces fragrance wine.The raw material of the present invention fully decomposes, and fermentation is complete；A variety of aroma-producing substances in raw material provide fragrance, and react to each other, and generate soft fragranced.