anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This research is interested in Counselling and Clinical Psychologists who have experienced client violence at their work place. The main research question being asked is how do psychologists' understand their personal experiences of client violence. This is an important and interesting subject for Counselling and Clinical Psychologists as it provides a detailed personal account of the implications of violence upon their personal and professional identity, psychological well being and how they define violence. Furthermore, this research may help facilitate in designing a specific policy and help future research to issue guidelines for counselling and clinical psychologists in order to keep themselves safe within their professional practice. Psychologists working for the National Health Service will be recruited and provided with information regarding the research aims and objectives. There will be interviews held at their place of work for approximately one hour.
<P>PROBLEM TO BE SOLVED: To prepare a cosmetic having a smooth feeling of use and good uniformity of a makeup film and excellent effects on making sulcus cutis inconspicuous.  <P>SOLUTION: This cosmetic is obtained by formulating the following ingredients (a) and (b). (a) a spherical particle having 25-35 μm particle diameter and (b) an oil. The cosmetic is characterized in that the particle content of the ingredient (a) in the whole spherical powder formulated in the cosmetic is 20-100 vol.%. The cosmetic for masking the sulcus cutis is characterized in that the ingredients (a) and (b) are formulated and the particle content in the ingredient (a) in the whole spherical powder formulated in the cosmetic is 20-100 vol.%.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The project will investigate the use of a novel technique, transcranial direct current stimulation (tDCS) in the treatment of patients with schizophrenia. tDCS permit the application of an extremely weak continuous electrical current to the brain through an anode and a cathode applied on the scalp. Anodal stimulation appears to increase brain activity whereas cathodal stimulation has the opposite effect.

Using anodal and cathodal tDCS the investigators aimed to treat negative symptoms of schizophrenia. The investigators plan to apply tDCS such that it can simultaneously increased activity in the frontal brain areas and reduce activity over temporoparietal cortex, 2 areas involved in the physiopathology of the disease. Real active stimulation will be compare to a sham condition in 44 patients (22 in each group). 44 patients will be included in Seoul National University Hospital
These 6 stores received a pricing intervention. 10-30% with discounts for specific foods contingent on price elasticity of demand, initial wholesale price, and projected store-level sales. Items were given the minimum discount needed to increase store supply and consumer demand. For example, brand name frozen vegetables were discounted 30% at the wholesaler, in order to provide the storeowner with enough incentive to stock the item. The % discount passed from the storeowner to the consumer was ultimately a decision made by the storeowner, but was suggested to be at least 50% in order to increase consumer demand. Discounts were automatically applied at wholesaler registers to stores receiving the pricing intervention.
A metabolic syndrome-improving agent that does not have a side effect problem and can be taken for a long period of time is provided. Auraptene is used as the metabolic syndrome-improving agent. Because auraptene has a PPAR α and Ϝ activating action, an adiponectin secretion promoting action in an adipocyte and a VLDL synthesis inhibiting action in a liver cell, the prevention, treatment or the like of a disease such as insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, obesity, visceral fat accumulation, hypertension, hyperlipidemia or arteriosclerosis is possible, whereby the prevention, treatment or the like of metabolic syndrome is possible. Because citrus that contains auraptene such as Citrus hassaku or Citrus natsudaidai has been eaten for a long time, there is no problem concerning safety, and in addition, it is low in calories, therefore it can be taken for a long period of time. Because auraptene is tasteless and odorless, even if it is added to food, it does not destroy the specific flavor of the food. Therefore, it can be taken by adding it to food.
The present invention relates to an ass-hide glue phospholipid composition and a preparing method thereof. Soybean phospholipid which has the functions of nourishing and bowel relaxing is added to ass-hide glue. Particularly, enzymolysis ass-hide glue is adopted, and small molecules are easily digested and absorbed. The method can replace a traditional ass-hide glue preparing method and has the same quality effect. Ass-hide glue phospholipid oral medicinal liquid, ass-hide glue phospholipid paste, instant ass-hide glue phospholipid agents and ass-hide glue phospholipid wine preparations which are prepared by the combination of the ass-hide glue and the soybean phospholipid of the present invention have the effect of eliminating the side effects of blood pressure increase and constipation which are caused by eating ass-hide glue. The ass-hide glue phospholipid composition of the present invention can not only tonify blood and arrest bleeding, but also strengthen the brain and benefit intelligence.
The invention provides a method for preparing a traditional Chinese medicine preparation containing Sambucus chinensis Lindl. extracts. The preparation comprises the Sambucus chinensis Lindl. extracts, micro silica gel and water in parts by weight. The preparation method comprises the following steps: grinding the Sambucus chinensis Lindl. extracts into fine powder and sieving the fine powder forstandby use; grinding the micro silica gel into fine powder, sieving the fine powder, adding water and mixing the fine powder with the fine powder of the extracts to prepare granules; directly tabletting and coating the granules, thus obtaining the preparation. The dose of the medicine prepared by the invention is greatly reduced and the compliance of the patients is improved; therefore, the preparation is favorable for clinical application.
FIELD: medicine. SUBSTANCE: invention relates to method of shark extracts preparing. Method involves preparing cartilage homogenate in an aqueous solution. Homogenate is separated for solid fraction (solid extract) and liquid fraction and the latter is subjected for fractionation to prepare liquid extract containing molecules with molecular mass 500 kDa or less. Invention involves some cosmetic use based on ability of liquid extract to improve function of cutaneous barrier. These shark cartilage extracts show rather perspective therapeutic significance. Unexpectedly valuable products obtained by the proposed method can be considered as an index of the novel and nontrivial method. EFFECT: simplified and effective method of preparing, valuable medicinal properties. 44 cl, 27 dwg, 9 tbl
Individually adjusted progressive and specific postural control training, provided by physiotherapists for one hour, one time per week for 8 weeks. The exercise is progressive and specific to functional postural control tasks. It comprises elements that represent activities included in, and required for, independent daily living, such as maintaining balance when sitting, standing and walking; and also reacting to loss of balance.
Breakthrough treatment for refractory and relapsed immune thrombocytopenia (ITP) patients is urgently needed. Autoantibody- mediated platelet clearance and megakaryocyte dysfunction are important pathogenic mediators of ITP. Glycoprotein (GP) Ibα is a significant autoantigen found in ITP patients and is associated with poor response to standard immunosuppressive treatments. Here, we engineered human T cells to express a chimeric autoantibody receptor (CAAR) with GPIbα constructed into the ligand-binding domain fused to the CD8 transmembrane domain and CD3ζ-4-1BB signaling domains. We performed cytotoxicity assays to assess GPIbα CAAR T-cell selective cytolysis of cells expressing anti-GPIbα B-cell receptors in vitro. Furthermore, we demonstrated the potential of GPIbα CAAR T cells to persist and precisely eliminate GPIbα-specific B cells in vivo. In summary, we present a proof of concept for CAAR T-cell therapy to eradicate autoimmune B cells while sparing healthy B cells with GPIbα CAAR T cells that function like a Trojan horse. GPIbα CAAR T-cell therapy is a promising treatment for refractory and relapsed ITP patients.
Background: Violence within nighttime entertainment districts (NEDs) has been blamed on problematic masculinity and has predominantly been attributed to excessive alcohol intake and steroid use in men. In this report we conducted two studies to: (1) ascertain whether researchers could act as third-party raters of body weight and muscle mass in NED patrons; and (2) to examine the relationship between body self-image, inebriation, alcohol preloading behaviors and drug use in the NEDs. Methods: Study 1 employed an observational approach to establish inter-rater reliability for ratings of muscle mass and weight. In Study 2 data (n = 2,745) were collected through breathalyzing and questionnaires to examine individuals' self-image and drinking and drug-taking behaviors. Results: Participants' self-ratings of muscle and weight significantly differed from researchers' ratings, with males perceiving themselves as less muscular and females perceiving themselves as heavier. Perceived weight and muscle size did not relate to alcohol levels, but an interaction was found for female steroid users who perceived themselves as less muscular. Conclusions: Findings indicated a distortion in participants' perceived body image, with a desire for muscularity among both males and females. These results underscore the complex interplay between self-perception, societal ideals, and drug use in young NED patrons.
PCT No. PCT/GB92/00124 Sec. 371 Date Nov. 8, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Jan. 22, 1992 PCT Pub. No. WO92/13081 PCT Pub. Date Aug. 6, 1992.A chimaeric protein, suitable for incorporation in a vaccine and capable of forming parts of a capsid assembly, comprises the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain capsid-forming capability, which amino acid sequence has been modified by insertion of a foreign epitope in the region corresponding to a protuberant protein hairpin in the capsid assembly as shown in the crystal structure of the intact phage.
Provided in the present invention are  anti-Mycoplasma spp.  subunit vaccines, especially proteins suitable for being used as the active ingredient of the  Mycoplasma spp.  subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of  Mycoplasma spp.  in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.
All enrolled subjects will initially be treated with the active study medication CCX140-B at a dose of 5 mg twice daily. Dose will increase in a step-wise fashion up to 15 mg twice daily.
BACKGROUND: Umbilectomy has been implemented in both abdominoplasties and deep inferior epigastric perforator (DIEP) flaps to improve abdominal wound healing and better control the location of the neoumbilicus; however, seroma rates are increased. The objective of this study is to compare the seroma rate following DIEP flap reconstruction with umbilectomy when progressive tension sutures (PTS) are implemented.
METHODS: A retrospective chart review was performed to evaluate postoperative seroma rates in patients undergoing DIEP flap breast reconstruction at a single academic institution between January 2015 and September 2022. All procedures were performed by two senior surgeons. Patients were included if their umbilicus was removed intraoperatively. PTS were utilized in all abdominal closures beginning in late February 2022. Demographics, comorbidities, and postoperative complications were evaluated.
RESULTS: A total of 241 patients underwent DIEP flap breast reconstruction with intraoperative umbilectomy. Forty-three consecutive patients received PTS. Overall complications were significantly lower in those who received PTS (p = 0.007). There were no abdominal seromas (0%) in patients who received PTS, whereas 14 (7.1%) occurred without PTS. The use of PTS conferred a decreased likelihood of abdominal seroma (5.687× lower risk, p = 0.017). Additionally, wound formation was significantly lower in those who received PTS (p = 0.031).
CONCLUSION: The use of PTS in the abdominal closure during DIEP flap reconstruction addresses the previously seen rise in seroma rates when concomitant umbilectomy is performed. Decrease in both donor-site wounds and now seroma rates reaffirm the efficacy of removing the umbilicus to improve patient outcomes.
Participant will receive darolutamide twice daily for 21 days (+ up to 7 days) unless unacceptable toxicity or withdrawal of consent. Following the 21 days of study treatment, participants should undergo radical prostatectomy on Day 22 (+ up to 7 days).
The primary objective of this paper is to delineate and elucidate the contemporary advancements, developments, and prevailing trajectories concerning intrastent restenosis (ISR). We aim to provide a thorough overview of the most recent developments in this area, covering various aspects such as pathophysiological insights, therapeutic approaches, and new strategies for tackling the complex challenges of ISR in modern clinical settings. The authors have undertaken a study to address a relatively new medical challenge, recognizing its significant impact on the morbidity and mortality of individuals with cardiovascular diseases. This effort is driven by the need to fully understand, analyze, and possibly improve the outcomes of this emerging medical issue within the cardiovascular disease field. We acknowledge its considerable clinical implications and the necessity for innovative methods to mitigate its effects on patient outcomes. Therefore, our emphasis was directed towards elucidating the principal facets of the condition's prevalence, expounding upon the foundational mechanisms underscoring conspicuous restenosis, and delineating the risk factors relevant in shaping the contemporary landscape of diagnostic and therapeutic modalities. This thorough examination aims to provide a comprehensive understanding of the various dimensions of the condition, including epidemiological data, pathophysiological complexities, and clinical considerations critical for evaluating and enhancing current diagnostic and treatment approaches.
OBJECTIVES: Abdominal aortic aneurysms (AAAs) demonstrating hostile neck anatomy (HNA) are associated with increased perioperative risk and mortality. A number of these patients are not suitable for standard endovascular aneurysm repair (EVAR) and are high risk for open surgery. We present our experience with the first implantations in Scotland of a novel conformable aortic stent-graft designed to overcome some of the challenges of HNAs.
METHODS: From May 2018 to March 2022, 24 consecutive patients with non-ruptured AAAs demonstrating HNAs (neck length < 15 mm, or angulation > 60°) were treated with GORE Excluder Conformable AAA endoprosthesis (CLEVAR) (CEXC Device, W.L. Gore and Associates, Flagstaff, AZ, USA) at a Scottish vascular centre. We assessed clinical outcomes and technical success of CLEVAR during deployment, primary admission and the post-operative period at 3- and 12-month clinical follow-up alongside CT angiography.
RESULTS: Twenty-four patients (20 males, mean age 75.6) were included. Primary technical success of proximal seal zones and CLEVAR deployment (no type 1/3 endoleaks, no conversion to open repair, AAA excluded and patient leaving theatre alive) was achieved in 100% of patients. All patients were alive and clinically stable at 3- and 12-month follow-up. There were five patients requiring re-intervention; at the 3-month follow-up, one patient (4.2%) developed a type 1b endoleak requiring graft limb extension, one patient developed a right common femoral artery dissection requiring open repair and one patient required a limb extension of the right iliac limb due to risk of developing a type 1b endoleak. At the 12-month follow-up, two patients required embolization of type 2 endoleaks and no patients demonstrated type 1 or type 3 endoleaks.Conclusions: In-hospital and post-operative 3- and 12-month clinical and angiographic outcomes demonstrate safety and efficacy with CLEVARs in treating unruptured AAAs with HNA. Further research involving larger heterogenous sample sizes is warranted to determine long-term clinical outcomes.
<P>PROBLEM TO BE SOLVED: To provide microparticles containing a precipitated bioactive factor.  <P>SOLUTION: Methods for preparing bioactive BMP-2 microparticles and methods for using the microparticles are disclosed. Pharmaceutical compositions containing the precipitated bioactive BMP-2 microparticles and pharmaceutically acceptable carriers are also provided. The BMP-2 has an amino acid sequence of human BMP-2 and is recombinantly expressed protein. The method for increasing the BMP-2 level in a subject to be tested includes a process for providing an aqueous BMP-2 suspension containing a resolubilizable BMP-2 polypeptide and a process for introducing a sufficient amount of the aqueous suspension to the subject to increase the BMP-2 level in the subject.  <P>COPYRIGHT: (C)2010,JPO&INPIT
The invention belongs to the technical field of biochemical engineering, and provides indole derivative-silver composite nano particles and a preparation method thereofMethod and use as bacteriostatic material. The indole derivative is nitroindole or tryptophan, wherein the nitroindole is n ‑NI, n =4,5,6, 7; tryptophan is Try. The composite nano-particles are prepared by mixing indole derivatives and Ag in a solvent containing nonionic surfactant and NaBH 4 Then compounding to obtain the composite nano particles, wherein the particle size range of the composite nano particles is 5-20 nm. The indole derivative and silver are compounded to obtain the composite nano-particles, and the indole derivative can slow down the coagulation of Ag NPs to form nano-particles with smaller particle size and obviously improve the antibacterial performance of the nano-particles. The prepared indole derivative-silver composite nano-particles have the advantages of good dispersion, uniform particle size, simple preparation method and easy storage. Not only can effectively inhibit bacteria, but also is difficult to generate drug resistance to bacteria.
BACKGROUND: Inadequate surgical interventions can lead to serious complications such as tubo-ovarian abscesses in the upper female genital system, often resulting from untreated pelvic inflammatory disease. Pelvic inflammatory disease, caused by infections like Chlamydia trachomatis and Neisseria gonorrhoeae, leads to scarring and adhesions in the reproductive organs, with common risk factors including intrauterine device use and multiple sexual partners. Pelvic inflammatory disease primarily affects sexually active young women and can manifest with varied symptoms, potentially leading to complications like ectopic pregnancy, infertility, and chronic pelvic pain if untreated.
CASE PRESENTATION: This case report presents a unique scenario involving a 17-year-old sexually inactive female who experienced concurrent tubo-ovarian abscess, acute cystitis, and pancolitis following laparoscopic ovarian cystectomy. Pelvic inflammatory disease and its complications are well-documented, but the simultaneous occurrence of acute cystitis and pancolitis in this context is unprecedented in the medical literature. The patient's presentation, clinical course, and management are detailed, highlighting the importance of considering diverse and severe complications in individuals with a history of gynecological surgeries.
CONCLUSIONS: Our case report highlights the need for healthcare professionals to remain vigilant for atypical presentations of gynecological complications and emphasizes the value of interdisciplinary collaboration for optimal patient care. We encourage further research and awareness to enhance understanding and recognition of complex clinical scenarios associated with gynecological procedures.
Most current self-management programs are developed for implementation by healthcare professionals. These professionals cannot fully perceive disease management needs and obstacles of older adults due to a lack of similar illness experience. To develop a self-management training program for older adult peer leaders with diabetes and to assess its feasibility.

This study was conducted in three stages. In stage 1, the peer leader training program was developed using experiential learning theory as the framework and self-regulation theory as the strategy for activity design. The 4-week training program was implemented for 4 hours/week. In stage 2, the feasibility of the training program was assessed. A peer leader training assessment tool was developed and used to evaluate peer leaders' leadership skills for self-management programs. Peer leaders' attendance rate and their viewpoints toward the training program through qualitative interview, willingness to lead self-management programs for older adults with diabetes in the community in the future were also assessed. In stage 3, This pilot study will take elderly diabetic patients in a community health station in Taiwan. The program will be conducted by peer leaders who have completed training to lead elderly diabetic patients and promote interaction, sharing, and support among peers. Improve self-confidence by guiding elderly diabetic patients to reflect on past self-management challenges and share successful self-management experiences. At the same time, learn how to find self-management problems, set goals and develop action plans, and other strategies to help elderly patients with diabetes set goals for their own health problems, develop and implement self-suitable, feasible and sustainable self-management behaviors to strengthen Self-management skills for elderly diabetic patients. The 4-week program was implemented for 2 hours/week.
Ixazomib beginning between day +100 to +150 at a dose of 4 mg orally once per week (3 weeks on/ 1 week off). The patients will continue on this same dose until taper off from immunosuppressants or 1 year post-HSCT is reached (whichever occurs first) or until the patient develops GVHD or malignant disease relapse/progression occurs.
The invention discloses a preparation method of anaphalis lactea maxim. total flavones and application of anaphalis lactea maxim. total flavones in preparation of a medicine for treating cholecystitis. The medicine provided by the invention can be prepared into various dosage forms according to the conventional preparation technology after anaphalis lactea maxim. used as a raw material medicine is extracted, purified through a macroporous resin and repurified through polyamide. The preparation method overcomes the defects in the prior art, and the application of anaphalis lactea maxim. total flavones in preparation of the medicine for treating cholecystitis is provided. The preparation method of the medicine provided by the invention is simple, the cost is low, and the clinical tests prove that the medicine has significant clinical effects on cholecystitis, and cholecystitis is unlikely to recur after cholecystitis is healed.