anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants will use the transauricular Vagus Nerve Stimulator provided to them by the lab for 14 days, 15 minutes prior to sleeping. Data will be collected via surveys, interviews, and Fitbit wear over the course of 2 months. A sleep diary will be kept to record sleep quality.
PURPOSE:To obtain a hair rinse agent composition having improved stability and rinse effect, containing no hydrophilic nonionic surface active agent, by preparing a highly concentrated emulsion from a small amount of a cationic surface active agent and a large amount of a specific oil, diluting it with water. CONSTITUTION:A hair rinse agent composition contaning (A) 0.05-0.5wt% cationic surface active agent such as a compound shown by the formula I (1-2 of R1-4 are 8-22C alkyl, etc., and the rest are 1-3C alkyl, etc.; X is halogen, etc.) and (B) 3-15wt% higher alcohol (e.g., alcohol having 12-26C alkyl, or alkynyl) having >=45 deg.C melting point or a glycerine monofatty acid ester [e.g., one shown by the formula II (R5 is 11-23C hydrocarbon)] based on the component A. In the preparation, a highly concentrated emulsion having 0.4-36wt% total amounts of the components A and B is diluted with 1-20 times as much water as the emulsion by weight. The composition may be further blended with 0.1-5wt% water-soluble high polymer compound as the component C. It is stable independent of temperature.
Prior studies have shown that sleep duration peri-vaccination influences an individual's antibody response. However, whether peri-vaccination sleep affects real-world vaccine effectiveness is unknown. Here, we tested whether objectively measured sleep around COVID-19 vaccination affected breakthrough infection rates. DETECT is a study of digitally recruited participants who report COVID-19-related information, including vaccination and illness data. Objective sleep data are also recorded through activity trackers. We compared the impact of sleep duration, sleep efficiency, and frequency of awakenings on reported breakthrough infection after the 2nd vaccination and 1st COVID-19 booster. Logistic regression models were created to examine if sleep metrics predicted COVID-19 breakthrough infection independent of age and gender. Self-reported breakthrough COVID-19 infection following 2nd COVID-19 vaccination and 1st booster. 256 out of 5265 individuals reported a breakthrough infection after the 2nd vaccine, and 581 out of 2583 individuals reported a breakthrough after the 1st booster. There was no difference in sleep duration between those with and without breakthrough infection. Increased awakening frequency was associated with breakthrough infection after the 1st booster with 3.01 ± 0.65 awakenings/hour in the breakthrough group compared to 2.82 ± 0.65 awakenings/hour in those without breakthrough (P < 0.001). Cox proportional hazards modeling showed that age < 60 years (hazard ratio 2.15, P < 0.001) and frequency of awakenings (hazard ratio 1.17, P = 0.019) were associated with breakthrough infection after the 1st booster. Sleep duration was not associated with breakthrough infection after COVID vaccination. While increased awakening frequency during sleep was associated with breakthrough infection beyond traditional risk factors, the clinical implications of this finding are unclear.
BACKGROUND: Calcium (Ca) is a nutritional factor that associated with dental caries. A recent study showed that in the case of adequate Ca intake, a higher level of physical activity may contribute to bone mass accumulation. However, the combined effect between Ca intake and physical activity on caries experience is unclear. Herein, we aimed to explore the above combined effect on dental caries in children and adolescents.
METHODS: Data of 5,917 children and adolescents were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2015-2020 in this cross-sectional study. The NHANES assessed the dietary Ca intake through the 24-hour dietary recalls, and the physical activity level was self-reported using the questionnaires. Also, the dental caries was diagnosed according to the Decayed, Missing and Filled Teeth/Surfaces (DMFT/S) index. Weighted univariate and multivariate logistic regression analyses were utilized to screen the covariates and to investigate the associations of dietary Ca intake and physical activity with dental caries, respectively, and assess the combined effect between dietary Ca intake and physical activity on dental caries. The evaluation indexes were odd ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses of age, obesity, and total sugar intake were also performed.
RESULTS: Among the eligible participants, 2,687 had caries experience. After adjusting for the covariates, we found that children and adolescents who not reach the recommendation level of Ca intake combined with physical activity less than 7 time in 1 week seemed to have higher odds of dental caries [OR = 1.77, 95%CI: (1.38-2.27)], compared with those who reached the standards. In addition, this potential combined effect was also found in age < 12 years old [OR = 1.62, 95%CI: (1.23-2.14)], non-obesity [OR = 1.88, 95%CI: (1.49-2.35)], and total sugar intake (all P < 0.05) subgroups.
CONCLUSIONS: Ca intake and physical activity had a potential combined effect on dental caries in children and adolescents, but the causal relationships between them needed further clarification.
Patients in the control arm will receive a usual care approach without the high focus on standardization given by the experimental arm (e.g. without flyers and booklets or standardized moments of face-to-face counseling). Data collection will be performed using a consistent approach with the one described in the experimental arm: every three months in a year (T0, T1, T2, T3, and T4).
Cascaded models may be applied to extract facts from a medical text. A first model may be applied to at least a portion of the medical text. The first model extracts at least one first medical fact. The at least one first medical fact is linked to at least first text in the at least a portion of the medical text. A second model may be applied to the first text. The second model extracts at least one second fact that is an attribute of the at least one first medical fact.
Musculoskeletal disorders, of which back pain accounts for more than half the number of cases, are the most common cause of chronic incapacity in industrialized countries. Approximately 10-20 percent of patients with low back pain develop chronic pain, defined as low back pain persisting more than 3 months. Low back pain represents a particularly costly sociomedical problem because of the expenditure associated with repeated treatment and the long-term absence from work and need for social support. These patients use more than 80% of health care resources for back problems, and treatment has a low success rate. Thus, the development of effective interventions aimed at management of the chronic problems is urgently required.

Review of studies showed that the effectiveness of stabilization exercises in patients with nonspecific LBP is not yet fully established. In clinical trials that improvement reported after motor control exercise, other intervention accompanied with these exercises. Also, the results of motor control exercise studies are different. On the other hand, the evidence underpins the primary aim of motor control exercise, which is to re-establish normal control of the deep spinal muscles, reducing the activity of more superficial muscles that tend to stiffen the spine and have increased activity in low back pain, and then maintain normal control during progressively more demanding physical and functional tasks. For these reasons, we decided to identify the efficacy of motor control exercises, usually considered as specific trunk muscle stabilization exercises. A randomized controlled trial was only way for identifying the role of these exercises in treating chronic low back pain. Also, our choice coincides with the research agenda set by the 2004 European Guideline.
Inactive topical gel identical in appearance to the active medication, provided in packets identical to the packaging for the active medication. Gel to be applied daily by participants. Participants are blinded to the contents of the gel packets. Participants in this arm also perform supervised exercise training for 6 months.
The present invention relates to a composition comprising an extract of Sapium discolor (Champ. ex Benth.) Muell. Arg. having an anti-inflammatory activity, and more specifically, to an anti-inflammatory cosmetic composition, an anti-inflammatory pharmaceutical composition, and an anti-inflammatory food composition, comprising an extract of Sapium discolor (Champ. ex Benth.) Muell. Arg. Since the extract of Sapium discolor (Champ. ex Benth.) Muell. Arg. of the present invention suppresses the production and secretion of inflammatory mediators such as NO and TNF-α, the compositions using the same as a raw material can effectively reduce inflammation, and thus the anti-inflammatory compositions comprising the same as an effective component may be applied as an anti-inflammatory agent for suppressing inflammation in inflammation-related diseases, a pharmaceutical composition having an anti-inflammation effect, a cosmetic composition, a health food composition, etc.
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the MDS-UPDRS Part III score at 12 months. 370 persons diagnosed with Parkinson's disease who have not yet initiated dopaminergic therapy, age 40-80, will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. Secondary objectives will test hypotheses related to striatal specific binding ratio (SSBR) at 12 months, MDS-UPDRS Part III score, ambulatory mobility (6-minute walk), daily walking activity (steps), cognition, quality of life, cardiorespiratory fitness, blood-derived biomarkers of inflammation and neurotrophic factors at 12 and 18 months. Tertiary objectives will test hypotheses related to 2 characteristics of ambulation at 12 and 18 months. Exploratory objectives will test hypotheses related to the effects of removing the study support that was provided over 18 months on the sustainability and durability of the exercise effects at 24 months. Approximately 29 sites will enroll participants: 27 sites that cover all geographic regions of the USA and 2 sites in Canada. All sites will have a collaboration between movement disorders and exercise specialists.
PURPOSE:To perform a required analysis at a high accuracy, by a method wherein in an antibody labelled by a specified substance is made to react with a carrier which has an antibody in solic phase on the surface thereof and is larger than the labelled antibody and then, the labelled antibodies bonded to the carrier in a reaction liquid and those not are separated by gel chromatography. CONSTITUTION:An antibody 3 labelled by a specified substance 4 and a carrier 1 having an antibody 2 in solid phase larger than the labelled antibody 3 are used to cause a reaction by adding a reaction buffer liquid containing a sample antigen 5. Then, with a chromatograph equipment, an antigen-antibody composite (Bound 6) in the reaction liquid is separated from the labelled antibody 3 (Free 7) having a labelling substance 4 not involved in an antigen-antibody reaction so called B-F separa tion. Then, changes in the quantity of scattering light and transmission light are detected with the chromatograph equipment together with the intensity of fluorescent light. At first, the fluorescent peak of the Bound 6 is obtained and that of the Free 7 one later. Thus, the density of the sample antigen is analyzed at a high accuracy from the calibration curve of the intensity of fluorescence and the density of the antigen obtained from an antigen with the known density based on the initial fluores cent peak.
Naloxone hydrochloride should be administered cautiously to persons including newborns of mothers who are known or suspected to be physically dependent on opioids. In such cases an abrupt and complete reversal of narcotic effects may precipitate an acute abstinence syndrome.  
The patient who has satisfactorily responded to naloxone should be kept under continued surveillance and repeated doses of naloxone should be administered, as necessary, since the duration of action of some narcotics may exceed that of naloxone.

Naloxone is not effective against respiratory depression due to non-opioid drugs. Reversal of buprenorphineinduced respiratory depression may be incomplete. If an incomplete response occurs, respirations should be mechanically assisted.
Carcinogenicity of timolol (as the maleate) has been studied in mice and rats. In a two-year study orally administrated timolol maleate (300mg/kg/day) (approximately 42,000 times the systemic exposure following the maximum recommended human ophthalmic dose) in male rats caused a significant increase in the incidence of adrenal pheochromocytomas; the lower doses, 25 mg or 100 mg/kg daily did not cause any changes. 

In a life span study in mice the overall incidence of neoplasms was significantly increased in female mice at 500 mg/kg/day (approximately 71,000 times the systemic exposure following the maximum recommended human ophthalmic dose). Furthermore, significant increases were observed in the incidences of benign and malignant pulmonary tumors, benign uterine polyps, as well as mammary adenocarcinomas. These changes were not seen at the daily dose level of 5 or 50 mg/kg (approximately 700 or 7,000, respectively, times the systemic exposure following the maximum recommended human ophthalmic dose). For comparison, the maximum recommended human oral dose of timolol maleate is 1 mg/kg/day. 

Mutagenic potential of timolol was evaluated in vivo in the micronucleus test and cytogenetic assay and in vitro in the neoplastic cell transformation assay and Ames test. In the bacterial mutagenicity test (Ames test) high concentrations of timolol maleate (5000 and 10,000 g/plate) statistically significantly increased the number of revertants in Salmonella typhimurium TA100, but not in the other three strains tested. However, no consistent dose-response was observed nor did the number of revertants reach the double of the control value, which is regarded as one of the criteria for a positive result in the Ames test. In vivo genotoxicity tests (the mouse micronucleus test and cytogenetic assay) and in vitro the neoplastic cell transformation assay were negative up to dose levels of 800 mg/kg and 100 g/mL, respectively. 

No adverse effects on male and female fertility were reported in rats at timolol oral doses of up to 150 mg/kg/day (21,000 times the systemic exposure following the maximum recommended human ophthalmic dose).
The importance of protein kinase B (AKT) in tumorigenesis and development is well established, but its potential regulation of metabolic reprogramming via phosphorylation of the hexokinase (HK) isozymes remains unclear. There are two HK family members (HK1/2) and three AKT family members (AKT1/2/3), with varied distribution of AKTs exhibiting distinct functions in different tissues and cell types. Although AKT is known to phosphorylate HK2 at threonine 473, AKT-mediated phosphorylation of HK1 has not been reported. We examined direct binding and phosphorylation of HK1/2 by AKT1 and identified the phosphorylation modification sites using coimmunoprecipitation, glutathione pull-down, western blotting, and in vitro kinase assays. Regulation of HK activity through phosphorylation by AKT1 was also examined. Uptake of 2-[1,2-3H]-deoxyglucose and production of lactate were investigated to determine whether AKT1 regulates glucose metabolism by phosphorylating HK1/2. Functional assays, immunohistochemistry, and tumor experiments in mice were performed to investigate whether AKT1-mediated regulation of tumor development is dependent on its kinase activity and/or the involvement of HK1/2. AKT interacted with and phosphorylated HK1 and HK2. Serine phosphorylation significantly increased AKT kinase activity, thereby enhancing glycolysis. Mechanistically, the phosphorylation of HK1 at serine 178 (S178) by AKT significantly decreased the Km and enhanced the Vmax by interfering with the formation of HK1 dimers. Mutations in the AKT phosphorylation sites of HK1 or HK2 significantly abrogated the stimulatory characteristics of AKT on glycolysis, tumorigenesis, and cell migration, invasion, proliferation, and metastasis. HK1-S178 phosphorylation levels were significantly correlated with the occurrence and metastasis of different types of clinical tumors. We conclude that AKT not only regulates tumor glucose metabolism by directly phosphorylating HK1 and HK2, but also plays important roles in tumor progression, proliferation, and migration.
The SLF technique will be performed as described by Richter et al (Amreich, 1951). Two long acting bioresorbable sutures are passed through the right sacrospinous ligament and then fixed to the vaginal cuff.
PURPOSE: An adhesive color light patch is provided to prevent adhesive force from being lowered and to be used under water. CONSTITUTION: An adhesive color light patch comprises a patch type body(10), a suction pad(20), and an adhesive sheet(30). The patch type body is equipped with a beam lighter containing a light source, a control circuit, an on/off switch, and a power supply battery. A light emission outlet is formed in the front central part of the patch type body. The suction pad is attached to the front outside of the patch type body and forms a penetration hole for optical transmission in the central part thereof. A sheet adhesive is attached to the inner surface of the adhesive sheet.
Patients with supratentorial ependymoma (Grade II without GTR1 or Grade III) or any infratentorial ependymoma who have undergone gross or near total resection (GTR or NTR) or achieved CR either after first or second resection or after post-operative induction chemotherapy are randomized to undergo conformal radiotherapy over 6-7 weeks followed by maintenance chemotherapy. Maintenance chemotherapy comprised of vincristine IV on days 1, 8, and 15 of cycles 1-3 only, etoposide IV over 60-120 minutes on days 1-3, cisplatin IV over 1-8 hours on day 1, and cyclophosphamide IV over 30-60 minutes on days 2-3. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients without GTR or NTR at enrollment require induction chemotherapy (see Arm I) and possibly second surgery before randomization.
PROBLEM TO BE SOLVED: To provide capsules filled with a cyclosporine solution where cyclosporine is dissolved in an ethanol-free liquid medium. SOLUTION: Cyclosporine is dissolved in a mixed liquor consisting of (A) 1-3 pts.wt. propylene glycol, (B) 2-4 pts.wt. monoester of polyglycerin with a fatty acid both based on 1 pt.wt. cyclosporine and (C) a proper quantity of extender and/or viscosity modifier, and then the resultant solution is filled into capsules. The weight ratio of cyclosporine: propylene glycol: monoester of polyglycerin with a fatty acid is preferably 1:2:3.
Initially, gastrointestinal disturbances such as nausea, vomiting, or diarrhea together with drowsiness, dizziness, lightheadedness or headache may occur. Early in the course there may be malaise or sluggishness followed by marked loss of muscle tone, making voluntary movement impossible. The deep tendon reflexes may be decreased or absent. The sensorium remains intact, and there is no peripheral loss of sensation. Respiratory depression may occur with rapid, irregular respiration and intercostal and substernal retraction. The blood pressure is lowered, but shock has not been observed.
The invention belongs to the technical field of genetic engineering production of fusion protein medicines in biotechnological pharmaceutical engineering. According to the invention, with an overlap extension PCR technology, thanatin gene and pinellia ternata agglutinin (PTA) gene are connectively jointed into a PTA-linker-thanatin-coded fusion protein gene by using a Linker flexible peptide (Gly4Ser)2 gene. Through an escherichia coli (E. coli) expression system, PTA-linker-thanatin fusion protein is expressed. As a result of experiments, the experimental product has strong important physiologic functions such as cancer inhibiting and bacteria resisting. PTA agglutinates and combines vigorously growing cancer cells, and has inhibiting effect against human and animal retrovirus (including HIV). Antibacterial peptide has characteristics such as selectivity effect and non-antigenicity. Therefore, under current conditions of drug resistance and difficulty in screening novel antibiotics, PTA-linker-thanatin fusion protein has potential to be developed into a novel generation of anticancer and antibiosis multifunctional medicine. The fusion of vegetable protein and animal protein provides a novel concept for the preparation of fusion protein products, and has wide prospect in the fields of scientific researches and medicine developments.
PURPOSE: A silicon powder complex particle and a cosmetic composition containing the same are provided to improve molding property and to express natural make up effect. CONSTITUTION: A silicon powder complex particle(10) contains a core(11) formed of silicon powder and a shell(17) which covers the core and formed of a complex. The complex is coated with silicon resin on the surface of organic powder. The average particle size of silicon powder 3-100um. The organic powder is mica, synthetic mica, sericite, talcum, complex-silicate, clay, synthetic clay, silica, aluminum oxide, barium sulphate, titanium dioxide, hydroxyapatite, or mixture thereof. The silicon resin is poly methyl silsequioxane. A cosmetic composition contains the silicon powder complex particles.
Depressive pseudodementia (DPD) is a debilitating cognitive dysfunction that accompanies major and/or frequent depressive attacks. DPD has gained significant research attention owing to its negative effects on the patients' quality of life and productivity. This study tested the procognitive potential of Flibanserin (FBN), the serotonin (5HT) receptor modulator, against propranolol (PRP), as β/5HT1A receptors blocker. Serving this purpose, female Wistar Albino rats were subjected to chronic unpredictable stress (CUS) and subsequently treated with FBN only (3 mg/kg/day, p.o), PRP only (10 mg/kg/day, p.o), or PRP followed by FBN, using the same doses. FBN ameliorated the behavioral/cognitive alterations and calmed the hypothalamic-pituitary-adrenal (HPA) axis storm by reducing the levels of stress-related hormones, viz, corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), corticosterone (CORT) parallel to epinephrine (EPI) hyperstimulation. The maladaptive inflammatory response, comprising of interleukin (IL)-1β/6, and tumor necrosis factor (TNF)-α, was consequently blunted. This was contemporaneous to the partial restoration of the protein kinase-B (AKT)/glycogen synthase kinase (GSK)3β/signal transducer and activator of transcription (STAT)-3 survival trajectory and the reinstatement of the levels of brain derived neurotrophic factor (BDNF). Microscopically, FBN repaired the hippocampal architecture and lessened CD68/GFAP immunoreactivity. Pre-administration of PRP partially abolished FBN effect along the estimated parameters, except for 5HT2A receptor expression and epinephrine level, to prove 5HT1A receptor as a fulcrum initiator of the investigated pathway, while its sole administration worsened the underlying condition. Ultimately, these findings highlight the immense procognitive potential of FBN, offering a new paradigm for halting DPD advancement via synchronizing adrenergic/serotonergic circuitry.