anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The mechanism of mood elevation by tricyclic antidepressants is at present unknown. Nortriptyline hydrochloride is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor effect of norepinephrine but blocks the pressor response of phenethylamine. Studies suggest that nortriptyline hydrochloride interferes with the transport, release, and storage of catecholamines. Operant conditioning techniques in rats and pigeons suggest that nortriptyline hydrochloride has a combination of stimulant and depressant properties.
The invention belongs to the technical field of beverage preparation and particularly relates to diaphragma juglandis fructus health-caring liquor which is composed of, by mass, diaphragma juglandis fructus, salviae miltiorrhizae, poria with hostwood, fructus lycii, eucommia ulmoides, semen platycladi, saffron crocus, radix glycyrrhizae and liquor. The liquor is mainly prepared from the diaphragma juglandis fructus with addition of the traditional Chinese medicines including the salviae miltiorrhizae, the poria with hostwood, the fructus lycii, the eucommia ulmoides, the semen platycladi, the saffron crocus and the radix glycyrrhizae, which have the effects of clearing heart to eliminate vexation, nourishing heart to quiet spirit, nourishing liver and improving eyesight, and tonifying blood and quieting spirit, wherein the health-caring liquor is prepared by soaking the processed traditional Chinese medicines along with the diaphragma juglandis fructus in liquor. The liquor has the effects of quieting spirit and tonifying brain, improving eyesight and refreshing oneself, and tonifying the qi and freeing blood. The medicines are packed in a filter bag and then are soaked in the liquor, so that the health-caring liquor has low impurities. The medicines are expanded in the filter bag continuously and are extruded with each other to carry out reactions, so that active components in the medicines are fully released and then are mixed with the liquor outside the bag. The health-caring liquor has better health-caring effects. The health-caring liquor is prepared from high-quality low-degree Maotai-flavor liquor, so that the health-caring liquor is low in alcohol degree, does not enable people to get drunk and has good taste.
The invention discloses a preparation method of a honeyed pill used for treating post-operation diarrhea. The preparation method comprises following steps: (1) rhizome of fourleaf paris, inonotus cuticularis (Bull.: Fr.) Karst., argyreia obtusifolia Lour., saussurea cordifolia hemsl., cyperus difformis L., lysima chiaauriculata Hemsl., raisin tree seed, dioscorea collettii Hook.f. root and stem, cyathus stercoreus(Schw.)de Toni or cyathus striatus willd, gelidium amansii, linearstripe rabdosia herb, and platycodon grandiflorum are washed, impurities are removed, and the obtained raw materials are dried in the air, and are smashed into particles; (2) the particles obtained via step (1) are mixed with water for decoction, an obtained mixture is allowed to stand, 95% ethanol is added, an obtained solution is allowed to stand, and is subjected to centrifugation, an obtained supernate is subjected to spray drying, and then is smashed so as to obtain an initial material; and (3) the initial material is delivered into a pan, is fried with slow fire until color deepens, honey is added for honey refining, an obtained mixed material is stirred to be uniform, and is fried until an obtained product is not sticky, and then the product is made into pills. Combination of the honeyed pill is reasonable; curative effect is clear; and the honeyed pill can be used for treating post-operation diarrhea effectively.
BACKGROUND & AIMS: Malnutrition, a significant problem in patients with chronic kidney disease (CKD), is linked to lower health-related quality of life, longer and more frequent hospital admissions, worse functional capacity, and higher levels of morbidity. However, the extent of its impact on mortality is poorly elucidated. This systematic review and meta-analysis aimed to investigate the impact of malnutrition on mortality among CKD patients on dialysis.
METHODS: This meta-analysis was designed and performed in accordance with the PRISMA guidelines (CRD42023394584). A systematic electronic literature search was conducted in PubMed, ScienceDirect, and Embase to identify relevant cohort studies. The studies that reported nutritional status and its impact on mortality in patients were considered for analysis. The generic inverse variance method was used to pool the hazard ratio effect estimates by employing a random effects model. The Newcastle-Ottawa scale was used for the quality assessment. The statistical analysis was performed by utilizing RevMan and CMA 2.0.
RESULTS: A total of 29 studies that comprised 11,063 patients on dialysis whose nutritional status was evaluated were eligible for quantitative analysis. Based on a comparison between the "malnutrition" category and the reference "normal nutrition status" category, the results showed that the overall pooled hazard risk (HR) for mortality was (HR 1.49, 95% CI: 1.36-1.64, p < 0.0001). According to the subgroup analysis, the hemodialysis subgroup had greater mortality hazards (HR 1.53; 95% CI 1.38-1.70, p < 0.0001), compared to the peritoneal dialysis subgroup (HR 1.26; 95% CI 1.15-1.37, p < 0.00001). Additionally, the overall incidence of mortality was explored but the authors were unable to combine the results due to limitations with the data.
CONCLUSION: The findings conclude that malnutrition is a strong predictor of mortality among patients on dialysis, with the hemodialysis subgroup having a higher mortality hazard compared to the peritoneal dialysis subgroup. The results of this study will advocate for early nutritional evaluation and timely dietary interventions to halt the progression of CKD and death.
A process for preparing Asparagopsis oil composition comprising contacting Asparagopsis biomass with at least one oil to extract at least one bioactive from the biomass into the oil. The Asparagopsis may be selected from Asparagopsis taxiformis (red sea plume, limu kohu) and/or Asparagopsis armata (red harpoon weed). The oil may be an edible oil selected from the following oils e.g. a vegetable oil. The bioactive agent may be an antimethogenic agent such as bromochloroacetic acid (BCA), bromoform (BF), dibromoacetic acid (DBA), and dibromochloromethane (DBCM). Also claimed is the Asparagopsis oil composition produced by the process. Also disclosed is a feed supplement/feed supplemented with said supplement comprising the Asparagopsis oil composition. Also claimed is a method of reducing total gas production and/or methane production in a ruminant animal, the method comprising administering an effective amount of the Asparagopsis oil composition. The ruminant animal may be cattle.
During the no pepper control study day, subjects consumed an identical menu without black pepper. 60.8g of vegetable juice (vehicle) was consumed at each of the three study meals. 24-hour energy expenditure and substrate utilization will be measured.
A circulating, soluble form of DPPIV/CD26 isolated from human serum is disclosed. The serum form shares similar enzymatic and antigenic properties with the ubiquitous membrane form. However, in several biochemical aspects there are distinct differences. In particular, the circulating serum form has a molecular weight of 175 kDa (in contrast to the 105 kDa molecular weight of the membrane form), and it does not bind Adenosine Deaminase Type-1. Nevertheless, the circulating form expresses functional dipeptidylpeptidase IV activity and retains the ability to costimulate the T lymphocyte response to recall antigen. Circulating DPPIV has been determined to be the soluble form of a 175 kDa DPPIVCD26-related molecule rapidly expressed on the surface of activated T cells, prior to the expression of 105 kDa CD26. Although 105 kDa membrane type CD26 may be found in the serum in small amounts, the majority of serum DPPIV activity is provided by a novel peptidase structurally distinct from 105 kDa CD26/DPPIV. Polyclonal and monoclonal antibodies capable of distinguishing the 175 kDa form from the 105 kDa form are also disclosed.
The quality of warfarin treatment may be improved if management is guided by the use of models based upon pharmacokinetic-pharmacodynamic theory. A prospective, two-armed, single-blind, randomized controlled trial compared management aided by a web-based dose calculator (NextDose) with standard clinical care. Participants were 240 adults receiving warfarin therapy following cardiac surgery, followed up until the first outpatient appointment at least 3 months after warfarin initiation. We compared the percentage of time spent in the international normalized ratio acceptable range (%TIR) during the first 28 days following warfarin initiation, and %TIR and count of bleeding events over the entire follow-up period. Two hundred thirty-four participants were followed up to day 28 (NextDose: 116 and standard of care: 118), and 228 participants (114 per arm) were followed up to the final study visit. Median %TIR tended to be higher for participants receiving NextDose guided warfarin management during the first 28 days (63 vs. 56%, P = 0.13) and over the entire follow-up period (74 vs. 71%, P = 0.04). The hazard of clinically relevant minor bleeding events was lower for participants in the NextDose arm (hazard ratio: 0.21, P = 0.041). In NextDose, there were 89.3% of proposed doses accepted by prescribers. NextDose guided dose management in cardiac surgery patients requiring warfarin was associated with an increase in %TIR across the full follow-up period and fewer hemorrhagic events. A theory-based, pharmacologically guided approach facilitates higher quality warfarin anticoagulation. An important practical benefit is a reduced requirement for clinical experience of warfarin management.
Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs containing Kupffer cells (KuLOs) by recapitulating fetal liver hematopoiesis using human induced pluripotent stem cell (hiPSC)-derived erythro-myeloid progenitors (EMPs), the origin of tissue-resident macrophages, and hiPSC-derived LOs. Remarkably, LOs actively promote EMP hematopoiesis toward myeloid and erythroid lineages. Moreover, supplementing with macrophage colony-stimulating factor (M-CSF) proves crucial in sustaining the hematopoietic population during the establishment of KuLOs. Exposing KuLOs to sepsis-like endotoxins leads to significant organoid dysfunction that closely resembles the pathological characteristics of the human septic liver. Furthermore, we observe a notable functional recovery in KuLOs upon endotoxin elimination, which is accelerated by using Toll-like receptor-4-directed endotoxin antagonist. Our study represents a comprehensive framework for integrating hematopoietic cells into organoids, facilitating in-depth investigations into inflammation-mediated liver pathologies.
Treatment during Cycles 1 through 12 consisted of carfilzomib (15, 20, or 20/27 mg/m²) on Days 1, 2, 8, 9, 15, and 16; lenalidomide (10, 15, 20, or 25 mg) on Days 1 to 21; and low-dose dexamethasone (40 mg) given 30 minutes to 4 hours before the carfilzomib dose on Days 1, 8, and 15, as well as on Day 22. For Cycles 13 and higher, carfilzomib could be omitted on Days 8 and 9 at the investigator's discretion.
A mesh bag filled with decarboxylated marijuana and/or marijuana concentrates designed to fit in virtually any spirits bottle. Once submerged the alcohol absorbs the cannabinoid oils (THC/CBDs) and thereby become psycho-active. The Marijuana Spirit Spiker is a food grade mesh bag filled with decarboxylated marijuana and/or marijuana concentrates. The mesh bag is designed to fit into virtually any ‘hard’ alcohol bottle and be added to the bottle by the consumer after purchase. Once submerged in alcohol, the marijuana and/or marijuana concentrates in the MSS absorbs into the alcohol. The alcohol will absorb the cannabinoid oils (THC/CBDs) and become psycho-active.
Subjects 18 to 55 who do not have psoriasis or rheumatologic conditions, including rheumatoid arthritis and systemic lupus erythematosus. This group of subjects will complete a CCTA (Coronary CT Angiogram)scan.
Prepn. of anti-mastitis vaccine by separately forming a detoxified alpha-toxin, a detoxified leucocidin and a surface antigen, all obtd. from selected strains of Staphylococcus aureus by pptng. each, and mixing the precipitates in predetermined quantities, and then drying and powdering the mixture. Preventing and treating staphylococcal mastitis in cows; can be admin. intranasally, intravaginally or intramammally. 40 units alpha-toxin, 3 units leucocidin and 3X10 antigens from six strains of Staph. aureus dissolved in water and admin. to cows as nasal drops.
<P>PROBLEM TO BE SOLVED: To provide a moisture absorbing and retaining pigment having an excellent feeling when used, and excellent in moisture absorption and retention, without using collagen, and to provide a cosmetic compounded with the pigment, having an excellent moisture feeling in an area to which the cosmetic is applied, and capable of keeping the moisture feeling.  <P>SOLUTION: This moisture absorbing and retaining pigment is obtained by subjecting surfaces of the pigment to surface coating treatment with a synthetic or semisynthetic water-soluble polymer. The pigment has the excellent feeling when used, and is excellent in the moisture absorption and retention. Further, the cosmetic is compounded with the moisture absorbing and retaining pigment. The cosmetic has the excellent moisture feeling in the area to which the cosmetic is applied, and further keeps the moisture feeling.  <P>COPYRIGHT: (C)2003,JPO
BACKGROUND AND AIMS: Recent research has shown that Western-style diets have been associated with an increased risk of inflammatory bowel diseases (IBD). Our aim was to examine the link between an anti-inflammatory diet and the maintenance of IBD remission, as well as to assess the potential therapeutic advantages of this dietary approach in preserving IBD remission.
METHODS: The inclusion and exclusion criteria were applied to a total of 189 individuals with IBD, with 21 individuals not meeting the criteria. Therefore, 168 eligible patients were enrolled in the study and allocated to either an anti-inflammatory diet or a regular diet, based on their personal preference.
RESULTS: A cohort of 168 IBD adult patients was recruited for the study: 88 patients with ulcerative colitis and 80 with Crohn's disease. The intervention group received an anti-inflammatory diet consisting of the removal of red and processed meat, fried foods, high-lactose foods, fast food, white bread, sugar, and vegetable oils rich in omega-6 for a period of 1 year. The clinical response was maintained in 80 patients (95.2%) in the intervention group and in 72 patients (85.7%) in the control group (p-value=0.036). Although not statistically significant, fecal calprotectin was higher in the control group than in the intervention group at follow-up.
CONCLUSIONS: Patients who adhered to an anti-inflammatory diet exhibited a higher rate of maintenance of clinical remission. Furthermore, improvement in inflammation tests was observed in the intervention group, reinforcing the proposition that IBD is a lifestyle-related disease.
Cosmetic composition comprises hydroxamate derivatives at 0.001-10 mass% and antioxidants at 0.00001-10 mass%. An independent claim is also included for process to stimulate collagen and fight against skin aging or provide anti-inflammatory and antioxidant effect to skin or prevent the formation of acne or suppress the sebum secretion on the skin or to inhibit tyrosinase on the skin, comprises the usage of the combination of hydroxamate derivative and antioxidant on the skin in a cream or lotion formulation or a formulation of elimination by washing. ACTIVITY : Dermatological; Antiseborrheic. MECHANISM OF ACTION : Tyrosinase inhibitor. The ability of the composition to inhibit tyrosinase was tested. The result showed that the salicylic hydroxamate inhibited tyrosinase 100% at 300 mu M. .
<P>PROBLEM TO BE SOLVED: To provide a tooth whitening product, more precisely, a tooth whitening product incorporated with a whitening agent.  <P>SOLUTION: The tooth whitening product 20 has a backing layer and a tooth whitening composition. The tooth whitening composition includes a first polymer, a second polymer, water and a tooth whitening agent. The first polymer is a water-soluble polymer, and the second polymer is a polyvinyl alcohol. The tooth whitening product 20 includes a water-soluble polymer film 22 and a solid whitening agent which is applied to one side face of the water-soluble polymer film 22 as a coating 24.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Levetiracetam weight based dosing for all participants 2-15 years of age, not to exceed 60 milligram per kilogram per day (mg/kg/day), as tolerated. The maximum recommended daily dosage is 3,000 milligram (mg).
BACKGROUND: The aim of our study is to compare the efficacy of epoprostenol and viscum album in the treatment of femoral head avascular necrosis with an experimental study. Our hypothesis is that viscum album, which has similar properties to epoprostenol on the vascular system, is as effective as epoprostenol in the treatment of avascular necrosis.
METHODS: Avascular necrosis was created on the femoral heads of 45 New Zealand type rabbits by surgical vascular deprivation method. The rabbits were divided into 3 groups. Group 1 was designed as a control group, in group 2 Ilomedin (epoprostenol analogue) was administrated to subjects and in group 3, Helixor (viscum album extract) was administrated. At the end of the study, there were nine subjects in each group. Osteocyte necrosis, bone marrow necrosis, new bone formation and cartilage degeneration were evaluated microscopically. The extent of bone necrosis and repair and involvement of epiphysis, the bone marrow cellularity ratio and trabecular bone volume were investigated.
RESULTS: Subchondral necrosis was seen in more animals in the control group (p=0.03). Osteoblastic and osteoclastic activity were more prominent in the Ilomedin group (p=0.25 and 0.07, respectively). It was seen that the cartilages of the subjects in the Helixor and Ilomedin groups were less damaged. In the Ilomedin group, more animals were seen in the chronic phase of the repair process than in the other groups (p=0.07). Bone marrow cellularity was higher in treatment groups (22% and 20,6% for Ilomedin and Helixor, respectively, p=0,04). Trabecular volume was found to be increased in damaged femoral heads in the treatment groups, the highest increased observed in the Helixor group (p=0.01).
CONCLUSION: Viscum album seems to be effective in decreasing the extention of necrosis and protecting the articular cartilage, and epoprostenol in increasing repair and regeneration.
Impaired cognitive functioning is a common feature of schizophrenia and other serious mental illnesses that is related to poorer psychosocial functioning and less benefit from psychiatric rehabilitation. Research shows that cognitive remediation for persons with serious mental illness improves cognitive functioning and response to psychiatric rehabilitation. There is also evidence that physical activity such as aerobic exercise confers a benefit to cognitive functioning in both clinical and general population samples. The cognitive benefit of exercise is hypothesized to be the result of enhanced brain-derived neurotrophic factor (BDNF; a protein that promotes plasticity, reduces degeneration, and stimulates nerve cell survival). However, the potential synergistic effects of cognitive remediation and exercise on cognitive functioning have not been investigated in persons with serious mental illness. This pilot randomized controlled trial will evaluate the impact of adding a peer run exercise program to a standardized cognitive remediation program on cognitive functioning in 30 people with schizophrenia, schizoaffective disorder or bipolar disorder. All study participants will receive a 10-week cognitive remediation program shown in previous research to improve cognitive functioning. One-half (N = 15) of the participants will also receive a peer-led exercise program designed to promote cardiovascular fitness. The primary research questions addressed are: 1) Does the addition of the exercise program to cognitive remediation lead to greater improvements in cognitive functioning than cognitive remediation alone?, and, 2) Are improvements in cognitive functioning mediated (explained) by exercise-induced increases in BDNF? The results of this pilot study will inform the design of a larger, more definitive trial to evaluate the potential benefits of combining cognitive remediation and exercise in improving cognitive functioning and response to psychiatric rehabilitation.
A method of modifying a particle that includes reacting a reactive compound having an X—[Y] n  reactive group with a secondary compound N—S-ZM to form a substituted reactive intermediate [Y] a —X—(N—S-ZM) b , and reacting the particle with the substituted reactive intermediate [Y] a —X—(N—S-ZM) b  to attach the substituted reactive intermediate to the surface of the particle to form a surface modified particle. The particle may comprise at least one of a dye particle, an inorganic pigment particle, an additive, or a combination thereof. X may be a sulfonyl, phosphoryl, or 1,3,5-triazinyl group. Y may be a halogen leaving group. N may be a nucleophilic group. S may be an organic group. ZM may be an ionizable end group. Also, n is an integer between 1 and 3, b is an integer between 1 and 3, and a=n−b. When n is equal to or greater than b, and wherein if b is 2 or 3, each N—S-ZM can be the same or different.
This study is a multi-center, open-label, prospective and observational study enrolling approximately 440 patients. The primary objective of this study is to examine the fever response rate after itraconazole IV (directly into the vein) is administered for more than 3 days to patients with neutropenic fever based on investigator's discretion. Follow-up will be performed before and after administration and for 7 days after administration. Study population consists of the patients who visit a study center during the study period and are judged to have neutropenic fever associated with hematologic malignancy such as acute leukemia, hodgkin's lymphoma, non-hodgkin's lymphoma, myelodysplastic syndrome, and multiple myeloma. The decision to treat patients with itraconazole is as per physician discretion and doses are determined based upon approved labeling recommendations and physician discretion. The safety and efficacy of itraconazole administered beyond 29 days is not yet been established in the treatment of fever in neutropenic patients suspected of systemic fungal infection. Itraconazole 200 mg IV twice daily for 2 days, for a total of 4 doses, then 200 mg IV once daily for 12 days. After the administration for a total of 14 days, itraconazole oral solution 200 mg (20 ml) twice daily should be continued for a total of 14 days
An operating room anesthetization management system includes a surgery database, a staff database, an operating room database, a management module and view module. The surgery database saves a plurality of surgery information. The staff database saves a plurality of staff information. The operating room database is saved a plurality of operating room information. The management module is connected to the surgery database, the staff database and the operating room database. The management module is configured to link the surgery information, the staff information and the operating room information before a schedule information is produced. The view module is configured to display the schedule information.