anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Lamb-Shaffer syndrome (LAMSHF, OMIM: 616803) is a rare neurodevelopmental disorder characterized by global developmental delay, intellectual disability, poor expressive speech, which is attributed to haploinsufficiency by heterozygous variants of SOX5 gene (SRY-Box Transcription Factor 5, HGNC: 11201) on chromosome 12p12. A total of 113 cases have been reported in the world, however, only 3 cases have been reported.in China. Here, we aimed to report novel variants of SOX5 gene and provide examples for clinical diagnosis by reporting the clinical phenotype of a series of Chinese patients with LAMSHF.
METHODS: This study retrospectively collected the information of families of LAMSHF patients in China. Whole Exome Sequencing (WES) were performed to confirm the diagnosis of 4 children with unexplained developmental delay or epilepsy. A minigene splicing assay was used to verify whether the splice variant affected splicing. Meanwhile, a literature review was conducted to analyze the clinical and genetic characteristics of patients with LAMSHF.
RESULTS: Three of the LAMSHF patients had a de novo heterozygous mutation in the SOX5 gene respectively, c.290delC (p.Pro97fs*30), chr12:23686019_24048958del, c.1772-1C > A, and the remaining one had a mutation inherited from his father, c.1411C > T (p.Arg471*). The main clinical manifestations of these children were presented with global developmental delays, and one of them also had seizures. And the results of the minigene experiment indicated that the splice variant, c.1772-1C > A, transcribed a novel mRNA product which leaded to the formation of a truncated protein.
CONCLUSIONS: Through a comprehensive review and analysis of existing literature and this study showed intellectual disability, speech delay and facial dysmorphisms were common clinical manifestation, while the seizures and EEG abnormalities were rare (21/95, 22.16%). Notably, we represent the largest sample size of LAMSHF in Asia that encompasses previously unreported SOX5 gene mutation, and a minigene testing have been conducted to validate the pathogenicity of the c.1772-1C > A splice variant. The research further expands the phenotype and genotype of LAMSHF while offers novel insights for potential pathogenicity of genes locus.
After intrathecal administration, the radiopharmaceutical is absorbed from the subarachnoid space as described below, and the remainder flows superiorly to the basal cisterns within 2 to 4 hours and subsequently will be apparent in the Sylvian cisterns, the interhemispheric cisterns, and over the cerebral convexities. In normal individuals, the radiopharmaceutical will have ascended to the parasagittal region within 24 hours with simultaneous partial or complete clearance of activity from the basal cisterns and Sylvian regions. In contrast to air, the radiopharmaceutical does not normally enter the cerebral ventricles.

Although the primary absorption of cerebrospinal fluid (CSF) into the blood stream occurs at the arachnoid villi, there is some evidence that a significant fraction of CSF is also absorbed across both the cerebral and spinal leptomeninges. Lesser quantities may also be absorbed across the ventricular ependyma. It is also generally held that these alternate routes of CSF absorption may assume primary importance when the major routes of the flow are pathologically obstructed. Approximately 65% of the administered dose is excreted by the kidneys within 24 hours and this increases to 85% in 72 hours.
The senescent microenvironment and aged cells per se contribute to tissue remodeling, chronic inflammation, and age-associated dysfunction. However, the metabolic and epigenomic bases of the senescence-associated secretory phenotype (SASP) remain largely unknown. Here, we show that ATP-citrate lyase (ACLY), a key enzyme in acetyl-coenzyme A (CoA) synthesis, is essential for the pro-inflammatory SASP, independent of persistent growth arrest in senescent cells. Citrate-derived acetyl-CoA facilitates the action of SASP gene enhancers. ACLY-dependent de novo enhancers augment the recruitment of the chromatin reader BRD4, which causes SASP activation. Consistently, specific inhibitions of the ACLY-BRD4 axis suppress the STAT1-mediated interferon response, creating the pro-inflammatory microenvironment in senescent cells and tissues. Our results demonstrate that ACLY-dependent citrate metabolism represents a selective target for controlling SASP designed to promote healthy aging.
The invention takes the traditional medical health preserving and beautifying theory as guidance, and based on the achievement of modern process technology, the invention aims to innovate and help to solve a health preserving and beautifying scheme which is safe, effective, appropriate in cost, simple and convenient to take and treats based on syndrome differentiation. The 'Reozhou Huan Yan Jiaonang' for harmonizing the physique is the main product. The prescription is composed of American ginseng, astragalus, angelica, radix rehmanniae, prepared rhubarb, frostbite, liquorice and other herbal medicines. It has the functions of benefiting qi, nourishing blood, relaxing the bowels, expelling toxin, dispersing blood stasis, reducing blood fat, promoting diuresis, eliminating turbidity, moistening skin, etc. Can be used for treating constipation, acne, and facial mottle due to deficiency of qi and blood, listlessness, and excessive toxic materials. The usage and dosage are as follows: 1-2 granules/time, 2 times/day, preferably moderate; or following the medical advice. Based on the main formula, the treatment can be carried out according to syndrome differentiation by adding or subtracting the medicinal flavors aiming at constitutional symptoms of yang deficiency, cold intolerance and yin deficiency and fire excess. It is worth repeatedly explaining that the health care tea has reasonable diet, good sleep, moisture retention, skin moistening and face refreshing. The heart is good, natural and reasonable, and risk is avoided. The product is used for removing turbidity and rejuvenating skin, is basically free of pain, damage and side effects, and is a health-care product integrating prevention, treatment and treatment.
The dispenser comprises a compartment of impervious material contg. an active agent and provided with a means for releasing the agent to the exterior of the device and a second compartment of a material of controlled permeability to water contg. a soln. of a solute which exhibits an osmotic press gradient against water, the two compartments being such that an increase in vol. of the latter when water is absorbed by osmosis causes a contraction in the former and the active agent to be extruded, the active agent being in the form of a solid or semi-solid. The dispenser is able to administer drugs when implanted in humans or animals.
Compositions for targeted delivery of a protective agent to the liver, and systems and methods for administering the compositions are described. When administered prior to or in combination with one or more chemotherapeutic agents, the compositions containing the protective agent protect the liver without adversely affecting the efficacy of the chemotherapeutic agent(s). Additionally, the use of these compositions enables the administration of higher doses of the chemotherapeutic agent(s). The compositions contain particles, comprising nanoparticles, microparticles, or combinations thereof, which contain a hepatoprotective agent. The systems contain a first formulation comprising particles that contain a protective agent to the liver and a second formulation comprising a chemotherapeutic agent. The particles containing the hapatoprotective agent are short circulating particles.
PROBLEM TO BE SOLVED: To prepare a promoter for the melanogenesis, capable of preventing dermatopathy due to ultraviolet rays and causing a deep and beautiful suntan simply by exposure to sunlight in a short time and useful for improvement in the color tone, blackening, etc., of the skin or hair. SOLUTION: This promoter for the melanogenesis is obtained by including apigenin or amentoflavone which is a dimer thereof or a plant extract containing both as an active ingredient alone or two or more thereof in combination in an amount of 0.001-10wt.% in the total amount. A solvent extract of Sabina chinensis (L.) Antone of the family Cupressaceae, Matricaria chamomille L. of the family Compositae, Selaginella tamariscina (Beauv.) Spring of the family Selaginellaceae, etc., or a commercially available product is used as the apigenin and the extract containing the apigenin. A solvent extract of the Selaginella tamariscina (Beauv). Spring of the family Selaginellaceae, Ginkgo biloba L. of the family Ginkgoaceae, Hypericum perforatum of the family Gutteriferae, etc., or a commercially available product is used as the amentoflavone and the extract containing the amentoflavone.  The promoter can be prepared as the dosage form such as an ointment, a lotion, a cosmetic oil, a cream, a milky lotion, a pack, a shampoo, a rinse, a hair tonic, a plaster, a juice, a candy, a tablet or a troche.
Nurses use the N95 Mask as part of the personal protective equipment (PPE) when caring for patients with COVID-19. The N95 mask covers their nose and mouth with a tight seal. Nurses wear the mask for more than 8 hours per day, as a result they are at increased risk for skin injury on the nasal bridge. Mepliex is foam dressing which has been used to prevent pressure injuries to the skin. This study will evaluate if using Mepilex or band-aid on the nasal bridge of the nurses who wear the N95 for more than 8 hours decreases the potential for skin injury. In addition, the investigators will test if the Mepilex or band-aid also maintains the seal of the mask. Maintaining the seal is important to ensure that the nurse is not exposed to the virus. The investigators will be working with nurses who do not directly take care of COVID-19 patients to ensure the safety of all participants.
The present invention provides methods of inhibiting orthopoxvirus replication and/or treating orthopoxvirus infection with certain nucleoside compounds and derivatives thereof as shown in the structural formula below. These compounds are particularly useful as inhibitors of vaccinia virus and variola virus replication and/or for the treatment of vaccinia virus and variola virus infection. The nucleoside compounds may be administered alone or in combination with other agents active against orthopoxvirus infection, in particular against vaccinia virus or variola virus infection.  Another aspect of the present invention provides for the use of such nucleoside compounds in the manufacture of a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection. Yet a further aspect of the present invention provides such nucleoside compounds for use as a medicament for the inhibition of orthopoxvirus replication and/or for the treatment of orthopoxvirus infection.   (see formula I)
The presently disclosed subject matter provides an inducible vector comprising a therapeutic gene. In some embodiments a method is provided for treating steroid glaucoma. In some embodiments a method is provided for preventing elevated intraocular pressure in a subject receiving steroid treatment. In some embodiments a method is provided for reversing elevated intraocular pressure in a subject receiving steroid treatment. In some embodiments a steroid treatment method is provided. Also provided are pharmaceutical compositions comprising an inducible vector.
AIMS: In patients with ST-segment elevation myocardial infarction (STEMI), prehospital tirofiban significantly improved myocardial reperfusion. However, its impact on the rate of disrupted myocardial infarction (MI), particularly in the context of high-sensitivity cardiac troponin (hs-cTn) assays, is still unclear.
METHODS AND RESULTS: The On-TIME 2 (Ongoing Tirofiban In Myocardial infarction Evaluation 2) trial randomly assigned STEMI patients to prehospital tirofiban or placebo before transportation to a percutaneous coronary intervention (PCI) centre. In this post hoc analysis, we evaluated STEMI patients that underwent primary PCI and had measured hs-cTn levels. Troponin T levels were collected at 18-24 and 72-96 h after PCI. Disrupted MI was defined as peak hs-cTn T levels ≤ 10 times the upper limit of normal (≤140 ng/L). Out of 786 STEMI patients, 47 (6%) had a disrupted MI. Disrupted MI occurred in 31 of 386 patients (8.0%) in the tirofiban arm and in 16 of 400 patients (4.0%) in the placebo arm (P = 0.026). After multivariate adjustment, prehospital tirofiban remained independently associated with disrupted MI (odds ratio 2.03; 95% confidence interval 1.10-3.87; P = 0.027). None of the patients with disrupted MI died during the 1-year follow-up, compared with a mortality rate of 2.6% among those without disrupted MI.
CONCLUSION: Among STEMI patients undergoing primary PCI, the use of prehospital tirofiban was independently associated with a higher rate of disrupted MI. These results, highlighting a potential benefit, underscore the need for future research focusing on innovative pre-treatment approaches that may increase the rate of disrupted MI.
PROBLEM TO BE SOLVED: To obtain the powdery make-up cosmetic excellent in the durability of the cosmetic purpose, cosmetic characteristics and skin moisture of the cosmetic coated on skin by compounding a pigment subjected to a specific treatment with a prescribed amount of an oily component. SOLUTION: This powdery make-up cosmetic contains a pigment coated with DNA or its water-soluble salt and 5-30wt.% of an oily component. The DNA-coated pigment or the pigment coated with the water-soluble salt of the DNA is obtained by dissolving or dispersing the DNA or its water-soluble salt in purified water, charging a pigment in the solution or dispersion, homogeneously mechanically dispersing the pigment, drying the dispersion, and subsequently grinding the dried product. The DNA is preferably a DNA which is slightly difficult to dissolve in water and has an average mol.wt. of 500,000-5,000,000. The amount of the coating is approximately 0.2-20.0wt.%. All of organic pigments and inorganic pigments except water-soluble pigments among the pigments can be coated. The oily component includes caster oil, jojoba oil, squalane, and methylsilicone.
Slow titration of Sertraline plus cognitive behavior therapy. The titration schedule utilized a slower titration schedule relative to the RegSert arm. Unless unable to tolerate higher doses, children remained on 25mg/day for the first two weeks, 50mg/day from weeks 3-4, 75mg/day for weeks 5-6, 100mg/day for week 7, 150mg/day for week 8, and 200mg/day for week 9 until the end of the study.
The invention provides a drug for treating tinea manuum, tinea pedis and psoriasis. The drug is made from the following materials (by weight proportions): trinitrotoluene 1.5-2.5, blister beetle poweder 0.005-0.045, salicylic acid 2-5, benzoic acid 2-5, sulfur 1.5-2.5, medical-grade ethanol 70-80, and vaseline 4.5-23. The drug is counted on basis of 100 weight proportions, and vaseline is added up to 100 weight proportions. The drug is characterized in rapid action, short treatment course and less side effects. The mechanism thereof is that the drug can inhibit the synthesis of sterols in fungal cell membranes to influence the permeability of cell membranes and inhibit the growth of fungi. The drug has the effects of nourishing blood, removing dryness and wind evils, eliminating toxic substances, removing damp evils, promoting blood circulation, and improving blood stagnation. The drug combines the advantages of Chinese and western medicines, and is mainly used to treat tinea manuum, tinea pedis and psoriasis.
PURPOSE: A method of extracting and simultaneous dividing of effective components of sophora flavescens using high performance liquid chromatography and liquid-liquid extraction are provided to simultaneously extract or divide the matrine, sophocarpin, sophoridine of representative effective components to the sophora flavescens. CONSTITUTION: The water is added to the sophora flavescens. The Sophorae flavescens is dipped in the water. Matrine, sophocarpin and sophoridine are extracted. Matrine, sophocarpin and sophoridine are the effective components of sophora flavescens. By using RP-HPLC(Reverse Phase-High Performance Liquid Chromatography) having moving phase, the Matrine, sophocarpin and sophoridine are divided from the sophora flavescens. The RP-HPLC includes the mixture of the methanol, water and diethylamine.
The functional alterations of the brain in bipolar II depression (BDII-D) and their clinical and inflammatory associations are understudied. We aim to investigate the functional brain alterations in BDII-D and their relationships with inflammation, childhood adversity, and psychiatric symptoms, and to examine the moderating effects among these factors. Using z-normalized amplitude of low-frequency fluctuation (zALFF), we assessed the whole-brain resting-state functional activity between 147 BDII-D individuals and 150 healthy controls (HCs). Differential ALFF regions were selected as seeds for functional connectivity analysis to observe brain connectivity alterations resulting from abnormal regional activity. Four inflammatory cytokines including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) and five clinical scales including Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Positive and Negative Syndrome Scale (PANSS), Columbia-Suicide Severity Rating Scale (C-SSRS), and Childhood Trauma Questionnaire (CTQ) were tested and assessed in BDII-D. Partial correlations with multiple comparison corrections identified relationships between brain function and inflammation, childhood adversity, and psychiatric symptoms. Moderation analysis was conducted based on correlation results and previous findings. Compared to HCs, BDII-D individuals displayed significantly lower zALFF in the superior and middle frontal gyri (SFG and MFG) and insula, but higher zALFF in the occipital-temporal area. Only the MFG and insula-related connectivity exhibited significant differences between groups. Within BDII-D, lower right insula zALFF value correlated with higher IL-6, CRP, and emotional adversity scores, while lower right MFG zALFF was related to higher CRP and physical abuse scores. Higher right MFG-mid-anterior cingulate cortex (mACC) connectivity was associated with higher IL-1β. Moreover, IL-1β moderated associations between higher right MFG-mACC/insula connectivity and greater depressive symptoms. This study reveals that abnormal functional alterations in the right MFG and right insula were associated with elevated inflammation, childhood adversity, and depressive symptoms in BDII-D. IL-1β may moderate the relationship between MFG-related connectivity and depressive symptoms.
Patients will receive home telemonitoring equipment and monitor their health for 60 days post-enrollment. A monitoring nurse will receive and review the patients health data on a daily basis for the 60 day duration and provide remote care, counseling and education.
The present invent relates to a lotion to which a heavy metal allergy-inhibiting watermelon rind is added. The present invention is a product solving inconvenience that rash and urticaria cannot be inhibited after rash and urticaria are generated as a patent applicant of the present invention and surrounding people who have been uncomfortable at ordinary times due to heavy metal allergy have their skins are brought into contact with heavy metals in the air when there is fine dust or yellow dust. There has been a problem that medicines capable of inhibiting or treating heavy metal allergy could not be obtained from the market. In order to solve this problem, a heavy metal allergy-inhibiting lotion using watermelon rind of the present invention includes: a lotion which is free from rejection symptoms to the skin, and to which a powder obtained by grinding a watermelon rind comprising a large amount of a heavy metal allergy-inhibiting ingredient is added; and a container in which the lotion is contained, and from which the lotion is discharged through an inlet when the container is pressed by the hand of a user. When the lotion, to which the heavy metal allergy-inhibiting watermelon rind is added, is applied to an affected part showing heavy metal allergy symptoms, rash and urticarial caused by heavy metal allergy are inhibited. The container which can be pressed to press out the lotion, and the inlet through which the lotion is discharged, are positioned in an outer upper portion of the lotion container main body and are connected to a cap. Accordingly, when the container is pressed by the hand of a user, the lotion is flown to the outside through the inlet.
Systems and methods for positioning a cut guide using navigation-based techniques are discussed. For example, a system for use in an orthopedic surgery on a target bone can comprise a cut guide adjustably positionable onto the target bone via two or more coupling receptacles created on the target bone. The coupling receptacles can include one or more guide members and a plurality of landing members. The system also includes an input interface that can receive a target bone representation, and a model receiver module that can receive a generic post-coupling bone model. The target bone representation can include a data set representing two or more landing sites of the target bone, and the generic post-coupling bone model can include a data set representing a bone having two or more coupling receptacles each sized, shaped or otherwise configured to receive and secure the respective coupling feature of the landing members. The system can include a navigation-based guide coupling preparation system that can generate a plan for positioning the cut guide onto or conforming to the target bone. The system can further include a display module that provides presentations of the coupling between the target bone and the cut guide.
AIM: PSE is reported more frequently in childhood than in adults. In this study, we aimed to investigate potential risk factors for the development of post-stroke epilepsy (PSE) in children with arterial ischemic stroke (AIS).
MATERIAL METHODS: The current retrospective cohort study included the medical records of 50 pediatric participants (aged 29 days to 18 years) diagnosed with AIS at a university hospital between January 2006 and December 2023. All information of the patients who were followed for at least two years for the development of PSE after AIS was entered into the hospital database and recorded in a pre-designed questionnaire. Acute symptomatic seizures were defined as seizures occurring within 7 days after stroke. Two or more late seizures occurring after the acute period (>7 days) were classified as PSE. The incidence of PSE and potential risk factors were investigated.
RESULTS: After AIS, more than half of the patients (58 %) developed acute seizures and almost one-third (38 %) developed PSE. Risk factors associated with the development of PSE, very early seizures (within the first six hours), high stroke severity, cortical lesions, neurological deficits and low serum vitamin D levels were detected (p = 0.05, p = 0.036, p = 0.011, p < 0.001, p < 0.001, respectively).
CONCLUSION: Seizures within the first six hours, high stroke severity, and neurological deficits are important risk factors for the development of PSE in children. Knowing the potential risk factors of PSE may be helpful for clinicians to identify high-risk patients. It can also contribute to treatment decision-making and post-discharge follow-up planning.