anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Primary electrical disorders (PEDs) are a group of cardiac rhythm abnormalities that occur in the absence of detectable structural heart disease and are a significant cause of sudden cardiac death (SCD). The initiation of cardiac muscle contraction and relaxation is orchestrated by the action potential (AP), generated through ionic changes across the membrane. Mutations in the AP-related gene CACNA2D1 have been identified as a causative factor for PED.
METHODS: We recruited a Chinese family with a history of arrhythmia. The proband has experienced palpitations and chest tightness for over 40 years, with symptoms worsening over the past year. Whole exome sequencing (WES) was used to determine the genetic etiologies in this family.
RESULTS: A novel heterozygous missense mutation (NM_000722.3: c.1685G > C;p.G562A) of CACNA2D1 gene was detected. Genotyping of the proband's parents indicated that the arrhythmia phenotype in the proband was caused by a de novo mutation.
CONCLUSIONS: WES was utilized to explore the genetic etiology in a family with arrhythmia, leading to the identification of a novel mutation in the CACNA2D1 gene. This study not only expands the mutation spectrum of the CACNA2D1 gene but also contributes to genetic counseling and clinical diagnosis for this family.
Compositions of matter suitable for use in food, feed, pharmaceutical, and beauty care products comprising a retinoid component and a fermentative residue thereof are disclosed herein. In an embodiment, the retinoid component is present in a ratio by weight relative to the fermentative residue of 4:1 or greater, wherein the retinoid contains cis- and trans-isomers, wherein the cis-isomers are present by weight relative to the entire mixture of isomers in an amount less than 3 wt. %. Preferably, the compositions are bio-based. Also described are biotechnological methods of producing the compositions elsewhere described, along with further methods for processing such compositions into more stabilized, more commercially acceptable forms. Finally, also disclosed are food, feed, pharmaceutical, and beauty care products incorporating the compositions herein described.
Ten young and healthy civilian participants will participate in the study. They will all go through a six days heat acclimation period in a heat chamber according to a valid protocol. After heat acclimation the participant will be randomly exposed to 4 conditions during four separate consecutive days: 1) walking on a treadmill for two hours in hot-wet conditions (30OC, 70% RH) while wearing military uniforms and a vest (control group); 2) walking on a treadmill for two hours in hot-dry conditions (40OC, 30% RH) while wearing military uniforms and a vest (control group); 3) walking on a treadmill for two hours in hot-wet conditions (30OC, 70% RH) while wearing military uniforms and a vest with a ventilator (experimental group); 4) walking on a treadmill for two hours in hot-dry conditions (40OC, 30% RH) while wearing military uniforms and a vest with a ventilator (experimental group). During the heat exposures, rectal temperature, skin temperature and heart rate will be continuously monitored. Subjective comfort measures, heat strain indices, sweat rate and sweat evaporation will be also measured/calculated. The differences in the above measures, during exposure to exercise in the heat between ventilator and no ventilator will be then analyzed.
A highly abrasive-resistant coating is intended esp. for machine parts subjected to abrasion from very hard, quartz-contg. substances such as machinery used in the prodn. of dental materials. The coating is made from an epoxy resin which contains a filler of greater hardness than the abrasive substances; this filler is present in fine granular or particulate form and in sufficient quantity to reach the limit of machinability. With this arrangement, there is no longer a tendency of the machine parts to be abraded by the hard materials in the product resulting in catalytic action or staining of the final products.
Two doses of 300 mg i.v. ocrelizumab two weeks apart followed by 600 mg i.v. ocrelizumab six months later.
The gastrointestinal (GI) tract plays an important role in the human body. The wall of the GI system regulates digestion and absorption of nutrients and it also has a very important function as a barrier between internal and external environment. The penetration of harmful substances and microbiota of the GI lumen (external environment) to the systemic circulation (internal environment) depends on this barrier. Previous studies have shown that exercise in healthy subjects provides hypoperfusion of the splanchnic area, resulting in intestinal damage, increased small intestinal permeability and liver damage. Similar splanchnic hypoperfusion occurs in patients with compromised circulation.

During episodes of splanchnic hypoperfusion, the de novo synthesis of nitric oxide (nitric oxide, NO) from arginine is compromised. This impaired NO synthesis may play a role in the development of organ dysfunction during exercise. L-citrulline administration, a precursor of arginine and NO, may result in improved NO availability and organ perfusion, thereby preventing organ damage.
Patients who underwent total/near-total thyroidectomy or completion thyroidectomy and require levothyroxine replacement therapy will be enrolled in this study. They will be randomized distributed into two groups. In one group, patients will be dosing LT4 according to weight-based algorithm, namely 1.6 μg /kg/d. In the other group, patients will be dosing LT4 according to the Poisson regression model algorithm. They will be followed up 3-6 weeks after surgery for the first time. During the follow up, thyroid hormone will be tested and LT4 dosing will be adjusted accordingly. Then, we compare patients in which group will achieve euthyroidism more quickly.
An augmented reality display system and method for use during surgery is disclosed. The imaging device captures a real image of the surgical field during the surgical procedure and generates a first data feed. The sensor device generates a second data feed. An augmented reality device including an augmented reality display generates an augmented overlay based on the first data feed and the second data feed. The enhanced overlay includes a visual portion and a non-visual portion. A processor receives the first data feed and the second data feed and combines the first data feed and the second data feed to generate the enhanced overlay.
These patients receive a placebo for the first 28 days of the study. They are then crossed over and receive armodafinil for the final 28 days of the study (days 29-56).
A novel atrial pacing approach will be delivered using the subject's already implanted pacemaker, ICD or BiV/ICD while the subject is in a semi-recumbent position and while hemodynamic and symptom data is collected. This will be repeated once daily, 3d/wk over 4 weeks.
The invention provides a preparation method of a medicine for preventing and treating acute upper respiratory tract infection. The medicine is prepared from the following raw materials in percentage by mass: 5 to 25 percent of fructus forsythiae, 8 to 25 percent of honeysuckle flower, 3 to 12 percent of field mint, 8 to 25 percent of great burdock fruit, 10 to 20 percent of balloon flower root, 6 to 15 percent of belamcandae root, 8 to 20 percent of isatis root, 8 to 20 percent of ledebouriella root, 8 to 20 percent of dryopteris root and 3 to 12 percent of licorice root. The raw medicines are extracted, concentrated, flocculated, clarified and then concentrated, and a preparation for preventing and treating acute upper respiratory tract infection is obtained under the condition of preserving the effect of raw medicines to a full extent. Proved by results of bacteriostatic tests on main pathogenic bacteria and pharmacology and toxicology tests on pain alleviation, inflammation resistance, and the like, the technology has the advantages of effectively enriching main active ingredients in raw medicines, reducing the losses of main active ingredients and improving antibacterial spectrum and bacteriostatic strength. The medicine effect, the safety and the reliability are better than those of a preparation made from the same raw materials with a traditional method. Meanwhile, preparation clarity can be improved, medicine occupation volume can be reduced, and the medicine is convenient to carry and convenient for children to take.
Elevated lactate levels are associated with a poor prognosis in patients with sepsis and shock. Intravenous glycerol administration is often used in Japan to treat patients with acute stroke or brain trauma, but such treatment can cause elevated lactate levels. We experienced a case of transient hyperlactatemia induced by intravenous glycerol administration in a patient with brain trauma. A 74-year-old woman underwent decompressive craniotomy because of loss of consciousness and brain edema. Glycerol was administered after the operation for management of the brain edema. Although the patient's hemodynamics remained stable, her lactate level decreased and increased repeatedly. We recognized that the elevation in her lactate level was associated with the administration of intravenous glycerol. This case suggests that intravenous glycerol administration can induce transient hyperlactatemia.
Patients receive olaparib PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Pregnancy Category B: Reproduction studies have been performed with Sectral in rats (up to 630 mg/kg/day) and rabbits (up to 135 mg/kg/day). These doses are equivalent to approximately 31.5 and 6.8 times the maximum recommended therapeutic dose in a 60-kg human, respectively. The compound was not teratogenic in either species. In the rabbit, however, doses of 135 mg/kg/day caused slight fetal growth retardation; this effect was considered to be a result of maternal toxicity, as evidenced by reduced food intake, a lowered rate of body weight gain, and mortality. Studies have also been performed in these species with diacetolol (at doses of up to 450 mg/kg/day in rabbits and up to 1800 mg/kg/day in rats). Other than a significant elevation in postimplantation loss with 450 mg/kg/day diacetolol, a level at which food consumption and body weight gain were reduced in rabbit dams and a nonstatistically significant increase in incidence of bilateral cataract in rat fetuses from dams treated with 1800 mg/kg/day diacetolol, there was no evidence of harm to the fetus. There are no adequate and well-controlled trials in pregnant women. Because animal teratology studies are not always predictive of the human response, Sectral should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
PURPOSE:A blood sugar lowering agent containing a polysaccharide produced by Bacillus polymyxa as an active ingredient. CONSTITUTION:Bacillus polymyxa (e.g., Bacillus polymyxa 271 and S-4, etc.) is inoculated into a medium obtained by blending a solution containing 3-5wt% glucose, sucrose, lactose, any of molasses, as a carbon source with a nitrogen source such as pepton, corn steep liquor, yeast extract, urea, etc. and magnesium sulfate, other salts, etc. cultivated under aerobic conditions, and a high-viscosity polysaccharide is obtained by a means such as precipitation with ethanol, methanol, etc. or ultrafiltration. A blood sugar lowering agent containing it as an active ingredient is obtained. The agent has a tablet, granule, capsule, etc. as the dosage form. A dose is 20-40mg/kg/day, it is administered daily three- four times dividedly.
By virtue of pragmatic inference-making, a listener can go above and beyond the linguistic meaning of the speaker's utterance in order to understand what the speaker intended to communicate. Such inferences allow the listener to understand inter alia irony, metaphor, indirect requests, scalar and ad-hoc implicatures. Autistic individuals have typically been described, by clinicians and language specialists, as tending towards having a literal understanding of language and as being deficient with respect to understanding a speaker's intended meaning, and these difficulties have a major impact on quality of life and social participation. Therefore, assessing these abilities seems essential, both for diagnosis purpose and to draw a clear description of an individual's functioning profile. Yet, no tool is available for children aged 8 to 12 in French. A new test named TIPi has been developed to resolve this issue. This new test is computerized and runs in a touch pad. The main goal of the present study is to evaluate the ability of the TIPi to discriminate autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) children from typically developing (TD) children. Secondary goals are (i) to measure the typical development of these abilities in TD children in this age range, (ii) to assess the developmental link these skills might have with other cognitive of language abilities (mentalizing, cognitive flexibility, core language skills, central coherence), and (iii) to compare the pragmatic profile of ASD children with another neurodevelopmental condition: developmental language disorder, in order to test the relevance of this test for differential diagnosis.
The present invention discloses tuckahoe sclerotium glucan sulfuric ester which has anti-tumor activity, a preparation method and application thereof. Fresh tuckahoe sclerotium is adopted; non-water soluble (1 to 3)-beta-D-glucan is extracted with NaOH; the non-water soluble (1 to 3)-beta-D-glucan is dissolved in anhyrous dimethylsulphoxide, pyridinium and chlorosulfonic acid are added, reaction is carried out, and glucan sulfuric ester is obtained. The substitution reaction of the glucan sulfuric ester belongs to non-selective substitution, the substitution reaction mainly occurs on C-6-position hydroxy, the substitution degree of a radical of the sulfuric ester is from 0.66 to 1.21, the weight average molecular weight is from 0.8*10<4> to 16.4*10<4>, and the water solubility is good. Biological activity experiments in vitro and in vivo show that the glucan sulfuric ester has the obvious inhibiting effect on Sarcoma 180 fleshy tumor and adenocarcinoma cells of the stomach of a human body. Mouse toxicity experiments prove that the half lethal dose (LD50) of the glucan sulfuric ester is more than 1600 mg/kg, and the glucan sulfuric ester has no toxic or side effect. The tuckahoe sclerotium glucan sulfuric ester can be used for preparing antitumor drug or health products for enhancing the immunological function of a human body.
Participants apply a high dose (6.5 mg) of vaginal DHEA gel QD, at bed time, for 12 weeks. Treatment continues until unacceptable adverse events or patient refusal to continue participation on the study.
A healthy lifespan relies on independent living, in which active skeletal muscle is a critical element. The cost of not recognizing and acting earlier on unhealthy or aging muscle could be detrimental, since muscular weakness is inversely associated with all-cause mortality. Sarcopenia is characterized by a decline in skeletal muscle mass and strength and is associated with aging. Exercise is the only effective therapy to delay sarcopenia development and improve muscle health in older adults. Although numerous interventions have been proposed to reduce sarcopenia, none has yet succeeded in clinical trials. This review evaluates the biological gap between recent clinical trials targeting sarcopenia and the preclinical studies on which they are based, and suggests an alternative approach to bridge the discrepancy.
FIELD: medicine, clinical immunology. SUBSTANCE: method involves preparing gluten by hydrolysis of wheat flour proteins with water. Hydrolyzate is settled for 10 min, supernatant fraction is inactivated at 53 C to obtain a dried powder and the latter is extracted with 70% solution of ethyl alcohol. The solution is centrifuged at 1000 rev/min for 10 min and supernatant liquid is inactivated at 53 C to obtain gliadin-containing dry powder. EFFECT: decreased cost of diagnosis process. 5 ex
Participants will receive 1 spray of esketamine solution in each nostril, 4 times with 10 minutes interval between each repeated sprays (total dose: 112 mg). Single dose of oral placebo will be administered 5 minutes before the first intranasal spray of esketamine solution.
Autoinflammatory disease (AID) is a vast spectrum of disorders characterized by recurrent attacks of sterile inflammation. Since the first cloning of the familial Mediterranean fever gene in 1997, there has been a rapid rate of discovery of new AIDs. As of 2022, there have been 485 inborn errors of immunity documented by the International Union of Immunological Societies, for which many display aspects of autoinflammation. The pathophysiology of AIDs is complex. Although many are caused by rare mutations in genes that govern innate immunity, others are polygenic, where disease expression is thought to be triggered by environmental factors in genetically predisposed hosts. AIDs range in prevalence from common entities like gout to ultrarare monogenic diseases. Whereas AIDs were initially studied in pediatric populations, it is now apparent that they can present in adulthood and even in the elderly. AIDs can be clinically challenging given their rarity, as well as the heterogeneity in presentation and underlying etiology. Although the care of AIDs can span medical disciplines, the rheumatologist often plays a central role given the inflammatory nature of these illnesses. In this review, we explore the current understanding of the pathophysiology of these complex conditions and propose a classification system for AIDs. We place an emphasis on AIDs that present to the adult rheumatologist and discuss important AIDs that can mimic more classic rheumatic diseases such as systemic lupus erythematosus and inflammatory arthritis. Finally, we offer an approach to the clinical assessment, diagnosis, and management of AIDs.
Risk Summary

Over decades of use, there is an absence of published data on orally administered glycopyrrolate in pregnant women, including an absence of any reports of a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. In animalstudies, at non-maternally toxic doses of oral glycopyrrolate, there were no adverse developmental effects in rats or rabbits. A pre-and post-natal development study of oral glycopyrrolate in rats showed a decrease in pup mean body weight that recovered post nursing, with no other developmental effects observed (see Data).

The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.

Data

Animal Data

At non-maternally toxic doses of oral glycopyrrolate, there were no effects on embryo-fetal development or toxicity in rats or rabbits. A pre-and post-natal development study of oral glycopyrrolate in rats showed a decrease in pup mean body weight that recovered post nursing, with no other developmental effects observed.

In a published reproductive and developmental study, male and female rats were administered glycopyrrolate in the diet at 0 mg/kg/day, 32.5 mg/kg/day, 63 mg/kg/day, and 130 mg/kg/day for 3 weeks to 5 weeks and through up to three consecutive litters. There was no indication of abnormalities in the pups of treated dams. There was a decreased rate of conception and in survival rate at weaning for all treated animals in a dose-related manner. Diminished rates of conception may be due to diminished seminal secretion [see Nonclinical Toxicology (13.1)].
PURPOSE: To provide an oral compsn. having an effect to whiten teeth when applied onto the surface of teeth. CONSTITUTION: This oral compsn. to whiten teeth contains peracetic acid as a soln. or suspension in a vehicle in a safe and effective amt. to whiten teeth. In the compsn. the peracetic acid is produced in the vehicle during use by mixing water, acetylsalicylic acid and a water-soluble alkali metal percarbonate.
PURPOSE:To use protein polysaccharide, especially krestin well-known as an antitumor agent derived from Basidiomyces belonging to the genus Coriolus versiclor as a safe central nervous system depressant. CONSTITUTION:Protein saccharide, an extract of cultivated mycelium or fruit body of Basidiomyces belonging to the genus Coriolus versicolor with hot water or an alkali solution, containing about 18-38wt% protein, having 5,000-300,000 molecular weight (ultracentrifugation method) is used as a central nervous system depressant, especially as an antipyretic analgesic. Protein polysaccharide derived from mycelium of Coriolus versicolor [FERM-P 2412(ATCC20547)] among protein saccharides is on the market as krestin. The protein polysaccharide is found to have analgesic and antipyretic action and effective as a central nervous system depressant. It has a synergistic effect with another central nervous system depressant, low toxicity, and almost no side effect. An oral dose is preferably 20-600mg/kg/day.
Participants will be randomized to one of 16 conditions. In addition to receiving the Core Components of the CHRP behavioral intervention, participants will receive one of the sixteen combinations of four compensatory components that show promise in terms of enhancing the ability to process and utilize HIV prevention content (see conceptual figure above), and that are not currently part of CHRP. The Attention Component includes: (a) Increasing frequency of sessions (more than once per week); (b) Distributed practice (spreading out information across sessions); (c) More structured sessions (well-organized objectives shared with patients); (d) Introducing new information during closure (foreshadow content of next session). The Executive Function Component includes the following strategies: (a) Associating behavior with situational cues (anticipate risky situations); (b) Linking actions to a triggering cue (storytelling techniques using imagery); (c) Planning (identify and organize steps required to meet goal) and (d) Valuing future events (recognize the benefits of drug treatment). Similarly, the Memory Component involves: (a) Memory aids (reminders and cues to be used between sessions); (b) Summarizing/reiterating information (frequent review throughout sessions); (c) Prospective memory (emphasize routine, develop cues, elaborate on positive behaviors); and (d) Environmental engineering (prepare for adverse events). Lastly, the Information Processing Component includes: (a) Mixed methods of presentation (verbal, visual, and hands-on); (b) Simple language (clear, concrete examples aligned with health literacy level); (c) Present content slowly (allow extra time for responses); and (d Immediate feedback following assessment (oral/ written).Of particular note, the investigators are using this framework to examine all combinations of these components (rather than merely testing all four) to promote ecological validity and future implementation. Specifically, our approach will help determine the most resource-efficient intervention, as there are many barriers to adding components to standard of care in these clinical settings. For example, if components targeting only two domains can produce equivalent outcomes as components targeting four, the former would be identified as preferred
Subjects that will be randomized in this group will receive their treatment as usual for the whole length of the study (10 weeks). TAU includes all the psychiatric therapies (pharmacological, psychological, occupational etc) that subjects may have begun before study's enrollment.