anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1486468 Transplanting ova etc; fractionating sperm L L AUGSPURGER 11 Nov 1974 [23 Nov 1973] 48625/74 Heading C6F [Also in Divisions A1 and C5] A process for transplanting ova, or cellular bodies derived from ova, from a female hoofed mammal donor to a recipient foster female for maturation involves receiving ova from the donor, placing the recovered ova in tissue culture medium and storing the recovered ova for a period of time in such a way as to defer normal development of the ova, determining the time of ovulation in the recipient, removing one or more of the individual ova or cellular bodies derived from the stored ova in the culture medium, and transplanting the removed individual ova or cellular bodies to the recipient at a time such that the transplanted ova or bodies reach the blastocyst stage in the recipient at the time the recipient would normally implant a blastocyst had the recipient been fertilized. Male producing cellular bodies are separated from the female producing bodies before transplantation, whereby the recipient may receive only transplants of like sex. The genetic manipulation of the ova and cellular bodies is described in considerable detail. The cellular bodies may be cultured at a temperature between 30 and 38C in a culture medium containing glucose, saline solution, amino acids, vitamins and sodium pyruvate prior to their transplantation. Detailed formulations of suitable culture media are provided. A preferred medium includes lipoic acid, 1-glutamine and vitamin B 12 , and is buffered with HERPES buffer and sodium bicarbonate to pH 7-3-7.4. A gaseous cover consisting of 5 vol. per cent carbon dioxide and 95% air or oxygen should be provided. The ova may be kept under liquid nitrogen in a medium containing sodium pyruvate or sodium oxaloacetate. The spermatozoa are also pre-sexed prior to their use in the fertilizing by fractionation into the X and Y chromosome bearing spermatozoa. This may involve percolating the spermatozoa through cation exchange resins (leaving untrapped the spermatozoa capable of producing female offspring) or anion exchange resins (leaving male producing sperm untrapped). Preferred cation exchange materials are copolymers of carboxylic divinyl benzene, copolymers of methacrylic acid with divinyl benzene, and copolymers of maleic anhydride with styrene and divinyl benzene. Preferred anion exchange resins can be produced by nitration and subsequent reduction of styrene divinyl benzene copolymers. Particularly in the case of cattle sperm, due to the great difference in size the of X and Y spermatozoa. fractionation may be achieved in a counterstreaming centrifuge using speeds between 1000 and 1200 rpm and speeds below 1000 rpm for the recovery of the male and female producing fractions, respectively. The percolation or centrifugation is preferably conducted under a vacuum of 15 to 30 cm. Hg differential from the pressure at which the sperm were obtained. Fertilization of the matured oocytes, or "pseudo-fertilization" by sterile sperm or chemically, may be made in vitro.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a long-term, progressive, and irreversible pulmonary interstitial disease. The activation of Smad family member 2 (Smad2) and Smad3 transcription factors by transforming growth factor β-1 (TGF-β1) is a critical event in the pathogenesis of IPF. However, there is still a lack of understanding regarding the molecular mechanisms governing Smad2 and Smad3 proteins. Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays a vital role in regulating protein stability within cells. However, its regulation of the TGF-β signaling pathway and its significance in IPF remain undiscovered. This study aims to clarify the function of USP7 in the TGF-β signaling pathway, while simultaneously exploring the specific molecular mechanisms involved. Additionally, this study seeks to evaluate the therapeutic potential of targeted USP7 inhibitors in IPF, thereby providing novel insights for the diagnosis and management of IPF.
METHODS: We first detected the expression of USP7 in lung tissues of mice with Bleomycin (BLM)-induced pulmonary fibrosis and in Beas-2B cells treated with or without TGF-β1 through Western blot analysis. Subsequently, we explored the influence of USP7 on fibrotic processes and the TGF-β1 signaling pathway, utilizing in vitro and in vivo studies. Finally, we assessed the effectiveness of USP7-specific inhibitors in an IPF murine model.
RESULTS: In the present study, USP7 was found to de-ubiquitinate Smad2 and Smad3, consequently increasing their stability and promoting the TGF-β1-induced production of profibrotic proteins including α-smooth muscle actin (α-SMA) and fibronectin 1 (FN-1). Inhibition or knockdown of USP7 resulted in decreased levels of Smad2 and Smad3 proteins, leading to reduced expression of FN-1, Collagen Type I Alpha 1 Chain (Col1A1), and α-SMA induced by TGF-β1 in human pulmonary epithelial cells. These findings demonstrate that overexpression of USP7 reduces Smad2/3 ubiquitination, whereas inhibition or knockdown of USP7 enhances their ubiquitination. USP7 is abundantly expressed in IPF lungs. The expressions of USP7, Smad2, and Smad3 were upregulated in bleomycin-induced lung injury. The USP7 inhibitor P22077 reduced the expression of FN-1 and type I collagen as well as Smad2/3 and collagen deposition in lung tissue in a model of pulmonary fibrosis induced by bleomycin.
CONCLUSIONS: This study demonstrates that USP7 promotes TGF-β1 signaling by stabilizing Smad2 and Smad3. The contribution of USP7 to the progression of IPF indicates it may be a viable treatment target.
BACKGROUND: Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them.
METHODS: Bidirectional two-sample Mendelian randomization (MR) analysis was performed to confirm the causal link between MDD, AXD and constipation. Genetic instrumental variables for MDD, AXD, and constipation were obtained from publicly available genome-wide association studies (GWASs). In this MR analysis, inverse variance weighting (IVW) was used as the primary analysis method to evaluate the causal effect. Additionally, we employed Cochran's Q test, MR‒Egger intercept and MR-PRESSO analysis to examine heterogeneity and pleiotropy. Moreover, leave-one-out analysis was employed to investigate the stability of the associations. Finally, a reverse analysis of Mendelian randomization was conducted.
RESULTS: The results revealed a causal relationship between MDD and an increased risk of constipation (p = 0.0001), whereas AXD (p = 8.52 × 10-1) did not increase the risk of constipation. In the inverse MR analysis, no causal associations were found (constipation to MDD: p = 9.37 × 10-1; constipation to AXD: p = 8.51 × 10-1).
CONCLUSION: This MR study revealed genetic evidence supporting a causal relationship between MDD and constipation.
It has been developed a strategy to simultaneously improve the properties of starch-based biomaterials for biomedical applications and the efficiency of therapeutical proteins. This new strategy which is revealed in this invention consists of the fusion of a carbohydrate binding module (CBM) with bioactive peptides. The human CBM used in this work has starch affinity (SBM). This SBM was identified as a module of a laforin enzyme, a phosphatase, which has the function to attribute glycogen affinity. As has been demonstrated the SBM does also have starch affinity. This is a low cost polysaccharide available in large quantities and with different properties which has increasingly raised interest for the development of biomedical applications. The biocompatibility, versatility and biodegradability are relevant starch characteristics for the development of applications as the controlled release of drugs and tissue engineering.
PURPOSE: To obtain a safe mamilla-protecting agent composition little in the irritation of skin and useful for preventing the mamilla treatment and mastitis of mammalian by adding a glycerol monofatty acid ester and a polyglycerol fatty acid ester to glycerol. CONSTITUTION: This composition comprises (A) 100 pts.wt. of glycerol, (B) 0.1-15 pts.wt. (preferably 0.2-10 pts.wt), of a glycerol 10-14C (preferably 10-12C) fatty acid ester, (B) 0.5-100 pts.wt. (preferably 1-60 pts.wt.) of a polyglycerol 8-18C fatty acid ester having degree of polymerization of glycerol of usually 4-10 and preferably a HLB of f8. The composition prevents the growth of microorganisms at a mamilla or in its peripheral parts, and prevents the fatigue, skin roughness and chapping of a mamma due to the suction of the mamilla.
The invention relates to polymeric nanoparticles and nanogels, which can contain, deliver, and/or release one or more active agents, such as biologically active molecules or fragrance molecules, and methods of preparing the polymeric nanoparticles and nanogels. The nanoparticles are crosslinked utilizing radiation (g-radiation) as the catalyst for free radical polymerization (see FIG.  1 ) rather than by toxic chemical means. The nanoparticles and nanogels can be modified, without limitation, with hydrophobic, hydrophilic, or ionic groups or moieties. or with enzymes. Methods of preparing nanoparticles and nanogels containing or encapsulating a variety of molecules, including biologically active molecules and fragrance molecules, are provided.
Treatment as usual will vary between centres and this will impact the effect size of the intervention (Ayling et al., 2015). We will therefore conduct structured interviews with clinicians at each study site to clarify the nature of treatment as usual at each centre. We will also use an adapted form of the Client Service Receipt Inventory (a well-established tool used in health economics) to track the amount of treatment received over the year (Beecham \& Knapp, 1992). The inventory will be administered at 8-week and 3-month, to measure patients' service usage.
Coronary artery bypass grafting (CABG) surgery is one of the main treatment options for patients suffering from coronary artery disease, a condition characterized by a build-up of cholesterol in the coronary arteries of the heart that affects 126 million people worldwide each year. During this procedure, cardiopulmonary bypass (CPB) takes over the function of the heart and lungs. In recent years, there has been a huge focus on reducing surgical trauma in this procedure, leading to the emergence of minimally invasive cardiac surgery (MICS) such as endoscopic CABG (endo-CABG). In these techniques, peripheral CPB with femoral arterial cannulation is the most commonly used strategy. However, the use of retrograde arterial perfusion is not without risk. It can cause that the upper part of the body only receives deoxygenated blood. The effect on the heart is not yet fully known. The hypoxemia could cause myocardial ischemia and this could damage the heart muscle cells.

It is reported in the literature that establishing adequate ventilation from the initiation of CPB to cardiac arrest can resolve this phenomenon. This approach was investigated in a recently performed double-blinded, randomized, controlled pilot study (n=10) of our research group. However, a larger randomized controlled trial was needed. Therefore, this research aims to investigate the effect of continued mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.
Maternal morbidity is defined as ill-health in a woman during pregnancy, irrespective of pregnancy site or duration, which is caused or aggravated by the pregnancy or its management, but which is not caused by accident or incident. This concept ranges from mild to severe maternal morbidity (SMM). Maternal near-miss (MNM) and potentially life-threatening conditions (PLTCs) are included as SMM.(Mekonnen et al., 2021) . Maternal mortality is an indicator of many parameters of maternal health, such as women's status, access to care and quality of care in low resource settings.(Mohammed et al., 2020) Maternal near-miss precedes maternal mortality, and women are still alive indicating that the numbers of near-misses occur more often than maternal mortality.(Mekonnen et al., 2021) Maternal near miss case is defined as "a woman who nearly died but survived a complication that occurred during pregnancy, childbirth, or within 42 days of termination of pregnancy"(Ninama et al., 2022) High risk pregnancy is defined as one where pregnancy is complicated by factor or factors that adversely affects the outcome- maternal or perinatal or both. Women with high-risk pregnancies should receive care from a special team of health care providers to ensure the best possible outcomes. (Arjariya \& Tiwari, .2021) .High-risk pregnancy was classified based on the guidelines provided by Pradhan Mantri Surakshit Matritva Abhiyan (PMSMA) for identification of high-risk pregnancy by health-care workers. The parameters considered for diagnosis of high- risk pregnancy were also defined as per the guidelines provided by PMSMA. Antenatal women with the following conditions were categorized under high-risk pregnancy: a. Severe anemia with hemoglobin level 140/90 mmHg) b. Hypertensive disorder in pregnancy (blood pressure \>140/90 mmHg) c. Previous history of lower segment cesarean section d. Bad obstetric history (history of obstructed labor) e. Low-lying placenta or placenta previa. .(Arjariya \& Tiwari.,2021)
The investigators aim to evaluate complete colonoscopies from 10 healthy subjects. This study is used as a first explorative study of how the human gut microbiota is distributed along the lower gastrointestinal tract. No comparable studies in an uncleansed bowel have been performed so far. The number of subjects is based on other studies investigating the microbial composition of mucosal- and faecal-associated microbiota in which a sample size of 10 was enough to detect a difference. An equal number of men and women will be recruited. Drop-outs will be replaced.
BACKGROUND: Malnutrition is prevalent in chronic obstructive pulmonary disease (COPD) and associated with adverse outcomes, while COPD is intricately linked to cardiovascular disease (CVD), sharing common risk factors. The controlling nutritional status (CONUT) score, a promising tool for assessing malnutrition, warrants investigation into its predictive ability for cardiovascular disease prevalence and mortality in COPD patients.
METHODS: Based on the National Health and Nutrition Examination Survey (NHANES), this study analyzed 1501 adult COPD patients from 1999 to 2018. The endpoints were CVD prevalence, mortality related to CVD, and overall mortality. We evaluated the correlation of the CONUT score with each outcome using logistic regression and Cox regression models. The prognostic evaluation of patients was conducted using Kaplan-Meier curves in accordance with the CONUT score. We formed the receiver operating characteristic (ROC) curves for evaluating the CONUT score's discriminative capability.
RESULTS: The prevalence of malnutrition was 21.31% in COPD populations. Logistic analyses suggested a distinct connection between the CONUT score and CVD prevalence (OR:1.86, 95%CI:1.28-2.70) in individuals with COPD. The CONUT score demonstrated a significant correlation with a heightened risk of CVD mortality (HR: 1.86, 95%CI: 1.27-2.74) and overall mortality (HR: 1.50, 95%CI: 1.18-1.91). The prognostic outcomes might be effectively discriminated by the CONUT score, as seen by the Kaplan-Meier curves.
CONCLUSIONS: In summary, the CONUT score provides an uncomplicated and readily attainable marker for forecasting CVD prevalence, total mortality, and mortality from CVD among COPD patients.
Cyclobenzaprine hydrochloride is a white, crystalline tricyclic amine salt with the empirical formula C20H21N•HCI and a molecular weight of 311.9. It has a melting point of 217º C, and a pKa of 8.47 at 25º C. It is freely soluble in water and alcohol, sparingly soluble in isopropanol, and insoluble in hydrocarbon solvents. If aqueous solutions are made alkaline, the free base separates. Cyclobenzaprine HCI is designated chemically as 3-(5H-dibenzo [a,d] cyclohepten-5-ylidene)-N, N-dimethyl-1-propanamine hydrochloride, and has the following structural formula:

Cyclobenzaprine HCl Tablets, for oral administration, are available in the following strengths: 5 mg and 10 mg. 

In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc, titanium dioxide, iron oxide yellow. Cyclobenzaprine HCl tablets 5 mg also contains FD&C yellow #6.
The intervention consists of a 1-hour individual counseling session relating to alcohol consumption and HIV sexual risk behaviors. Intervention counselors will assess alcohol-related sexual risk behaviors through the use of job aids that include a flip chart, guided scripts, activities, role plays, and a take home booklet. Counselors use motivational interviewing and interactive activities to discuss alcohol and HIV myths and facts, participants personal risk behaviors, and a decision-making activity that assists participants in weighing the pros and cons of engaging in risky behavior. Counselors also facilitate role plays to improve communication skills in risky situations, as well as a condom demonstration and skills session, and goal setting. In addition, men in the intervention arm will also receive two cell phone text messages 1-month and 4-months following enrollment to reiterate risk reduction messages.
Atrial fibrillation (AF) is an independent risk factor for stroke and systemic embolism. Cardiogenic and aortogenic emboli are causes of stroke or systemic embolism. Non-obstructive general angioscopy (NOGA) can be used to diagnose aortic intimal findings, including thrombi and atherosclerotic plaques, but little is known about NOGA-derived aortic intimal findings in patients with AF. This study focused on aortic intimal findings in patients with AF and evaluated the association between AF and aortic thrombi detected using NOGA. We enrolled 283 consecutive patients with coronary artery disease who underwent NOGA of the aorta between January 2017 and August 2022. Aortic intimal findings were screened using NOGA after coronary arteriography. The patients were divided into two groups according to their AF history (AF, n = 50 and non-AF, n = 233). Patients in the AF group were older than those in the non-AF group. Sex, body mass index, and coronary risk factors were not significantly different between the two groups. In the NOGA findings, the presence of intense yellow plaques and ruptured plaques was not significantly different between the two groups. Aortic thrombi were more frequent in the AF group than in the non-AF group (92.0 vs. 71.6%, p < 0.001). Multivariate logistic regression found that AF was independently associated with aortic thrombi (odds ratio 3.87 [95% CI 1.28-11.6], p = 0.016). The presence of aortic thrombi observed using NOGA was associated with AF in patients with coronary artery disease. The roles of aortic thrombi as well as cardiogenic embolism may require clarification.
PROBLEM TO BE SOLVED: To obtain a cosmetic stable at high humidity and high temperature and less expensive by placing a cosmetic preparation of a nonaqueous solvent or a high concentration alcohol into a high density polyethylene-made container having a specified thickness. SOLUTION: A cosmetic preparation obtained by dissolving, dispersing or emulsifying an organic component in a nonaqueous solvent or a high concentration alcohol is placed into a high density polyethyllene-made container having a thickness of >=700μm. The high concentration alcohol is preferably a solution which contains the alcohol in >=50wt.%. The organic component is pentadecanoic acid glyceride, a vitamin or its derivative, isopropylmethylferrole, hinokitiol, etc. The cosmetic preparation is preferably a hair tonic, a setting agent, a treatment agent, or a fleck and wrinkle-preventing agent. A high density polyethylene having a thickness of >=700μm is free from deformation, the loss of weight, the decomposition of active components, etc., at high temperature and it is also free from moisture absorption, deformation, etc., even under high humidity.
The limb-load biofeedback training focuses on altering habitual movement patterns to promote proper prosthetic limb loading with an emphasis on between-limb loading symmetry. Participants randomized to the EXP group will receive 12 biofeedback training sessions (1 in-person, 11 telehealth) tapered over 40 weeks.
Subjects identified to receive a robotic assisted laparoscopic prostatectomy.were randomized to either a 16 French or 20 French catheter at the completion of the prostatectomy. All prostatectomies were performed by one of three surgeons at the investigator's institution. Preoperative demographics and operative data were recorded for each group. Catheters remained in place for 7-14 days. Subjects were asked on postoperative day 7 to report their catheter-related pain and amount of opioid medication used. Urinary symptoms and quality of life scores and pads per day were recorded at 6 weeks and 12 weeks post-operatively.
Arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) have shown potential for differentiating tumor progression from pseudoprogression. For pseudocontinuous ASL with a single postlabeling delay, the presence of delayed arterial transit times (ATTs) could affect the evaluation of ASL-MRI perfusion data. In this study, the influence of ATT artifacts on the perfusion assessment and differentiation between tumor progression and pseudoprogression were studied. This study comprised 66 adult patients (mean age 60 ± 13 years; 40 males) with a histologically confirmed glioblastoma who received postoperative radio (chemo)therapy. ASL-MRI and DSC-MRI scans were acquired at 3 months postradiotherapy as part of the standard clinical routine. These scans were visually scored regarding (i) the severity of ATT artifacts (%) on the ASL-MRI scans only, scored by two neuroradiologists; (ii) perfusion of the enhancing tumor lesion; and (iii) radiological evaluation of tumor progression versus pseudoprogression by one neuroradiologist. The final outcome was based on combined clinical and radiological follow-up until 9 months postradiotherapy. ATT artifacts were identified in all patients based on the mean scores of two raters. A significant difference between the radiological evaluation of ASL-MRI and DSC-MRI was observed only for ASL images with moderate ATT severity (30%-65%). The perfusion assessment showed ASL-MRI tending more towards hyperperfusion than DSC-MRI in the case of moderate ATT artifacts. In addition, there was a significant difference between the prediction of tumor progression with ASL-MRI and the final outcome in the case of severe ATT artifacts (McNemar test, p = 0.041). Despite using ASL imaging parameters close to the recommended settings, ATT artifacts frequently occur in patients with treated brain tumors. Those artifacts could hinder the radiological evaluation of ASL-MRI data and the detection of true disease progression, potentially affecting treatment decisions for patients with glioblastoma.