anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A system and method for biomarker-outcome prediction and medical literature exploration which utilizes a data platform to analyze, optimize, and explore the knowledge contained in or derived from clinical trials. The system utilizes a knowledge graph and data analysis engine capabilities of the data platform. The knowledge graph may be used to link biomarkers with molecules, proteins, and genetic data to provide insight into the relationship between biomarkers, outcomes, and adverse events. The system uses natural language processing techniques on a large corpus of medical literature to perform advanced text mining to identify biomarkers associated with adverse events and to curate a comprehensive profile of biomarker-outcome associations. These associations may then be ranked to identify the most-common biomarker-outcome association pairs. Having a comprehensive profile of ranked biomarker-outcome data allows the system to predict biomarkers associated with a given disease and serious adverse events linked to biomarker data.
Phentermine hydrochloride is a sympathomimetic amine anorectic. Its chemical name is α,α, dimethylphenethylamine hydrochloride. The structural formula is as follows:

C 10H 15N•HCl M.W. 185.7 

Phentermine hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether.

Phentermine hydrochloride capsule USP is available as an oral capsule containing 15 mg or 30 mg of phentermine hydrochloride (equivalent to 12 mg or 24 mg of phentermine base).

a) powder-filled capsules containing 15 mg phentermine hydrochloride (equivalent to 12 mg phentermine) or 30 mg phentermine hydrochloride (equivalent to 24 mg phentermine) and inactive ingredients: colloidal silicon dioxide, corn starch, gelatin, lactose monohydrate, magnesium stearate.

In addition, the 15 mg capsules contain black iron oxide, FD&C red No. 3, FD&C yellow No. 5, titanium dioxide; and the blue and clear 30 mg capsules contain D&C red No. 28, FD&C blue No. 1. The ingredients in the black imprinting ink are shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, purified water, strong ammonia solution, potassium hydroxide and black iron oxide.
PURPOSE:To obtain a tooth bleaching method capable of safely bleaching stained tooth without giving undesirable effect on human body. CONSTITUTION:The surface of tooth is bleached by applying electrolytically oxidized water as a bleaching agent to the tooth as it is or in the form of a paste produced by impregnating the water in a water-absorbing material (e.g. silicon dioxide). The electrolytically oxidized water is produced by applying electric voltage to water and collecting the water rich in hydrogen ion and anions from the anode side. It has pH of <=2.5, an oxidation reduction potential of 1,130mV and a dissolved chlorine concentration of about 38ppm. The bleaching treatment is carried out after the cleaning of the tooth, moisture-proofing of gingiva and etching, water-washing and drying of the tooth. The bleached tooth is subjected to heating, removal of the bleaching agent and the moisture- proofing agent, washing and polishing. When the electrolytically oxidized water is used in the form impregnated in a water-absorbing material, the water is retained on the tooth surface over a long period to improve the bleaching efficiency.
This study aimed to identify differences in caregiver burden related to toileting assistance, and examine the factors associated with the most burdensome aspects of providing toileting assistance. In 2019, a self-administered postal survey was conducted with 743 caregivers of older adults who received subsidies for continence products in Komatsu City, Japan. Both family caregivers and nursing home staff answered questions regarding older adults' urinary/fecal symptoms, toileting assistance, and perceived caregiver burden. Older adults living at home had less need for toileting assistance than those in nursing homes. However, family caregivers experienced more burden than nursing home staff. The most frequent physical burden associated with toileting assistance for family caregivers was urinary/fecal leakage from absorbent incontinence products. This burden was linked to family caregivers providing care at home, using a combination of urinary pads and diapers, and symptoms that caused burdens on caregivers including urinary/fecal incontinence, nocturia, and no desire to urinate. These results suggest that leakage caused by the inappropriate use of urinary pads combined with diapers is a source of caregiver burden. Continence care experts should provide guidance to family caregivers of older adults, particularly those who are underweight and frail, regarding the selection and fitting of absorbent incontinence products.
The invention discloses a coastal glehnia root prescription granule and a preparation method and a quality control method thereof. The prescription granule takes the coastal glehnia root decoction pieces as raw materials to prepare the coastal glehnia root prescription granule through the technique procedures, such as twice water extraction, vacuum concentration, sponging drying, etc. 1g of the coastal glehnia root prescription granule is equal to 10-20g of crude drug. The quality of the coastal glehnia root decoction pieces and the coastal glehnia root decoction pieces and the coastal glehnia root prescription granule are identified by using IR fingerprint spectra. The coastal glehnia root prescription granule of the invention has complete and advanced production technique, specific and controllable quality control standard, scientific, advanced, rapid and operable detecting method related to the quality standard. A great number of experiments prove that the prepared soup of the coastal glehnia root prescription granule and the mixed simmered liquid of the classical prescription decoction pieces containing the coastal glehnia root have equal components, thus realizing the technique of full ingredient prescription granule and proving the reasonability of the technique of the invention; and in the invention, infrared spectroscopy technology is use for the quality control, rapidly solving a primary problem in macroscopic quality control of the traditional Chinese medicines-the identification of the truth of a traditional Chinese medicines.
Bracelet, arm ring, foot ring, wrist-watch and the system thereof of networking intelligent monitoring body temperature. The method comprises the following steps: annular thermoscope, service platform, management terminal. A user wears the annular thermodetector at the wrist, arm or ankle position, the thermodetector software controls the temperature measuring circuit to work, and the thermodetector software uploads body temperature data, monitoring time and product numbers. The service platform intelligently monitors the dynamic body temperature of the user, selects data and information to be processed by prevention and control personnel on site, and sends the data and information to the management terminal of the prevention and control personnel. The management terminal receives the wearing information, the fault information and the warning information. When a serious warning is received, isolation and diagnosis and treatment are carried out on the user with fever symptoms. And the device also has the function of identifying false body temperature measurement, so that the monitored body temperature data is real and reliable. The annular temperature measuring instrument can also have an attendance checking function. The invention can be widely applied to schools, enterprises, large-scale meeting places and residential communities. Is a key technology of digital epidemic prevention, has strong practicability and has global market.
Studies on COVID-19 complications in the literature have predominantly focused on patients treated in hospitals, particularly in intensive care units. Data on patients with mild to moderate symptoms who were followed up on an outpatient basis in primary care are quite limited. Therefore, our research investigated the incidence of thrombotic events within six months following infection in mild to moderate COVID-19 cases and the factors that might influence these events. Records of 961 individuals registered at two different family health centers in Istanbul were reviewed. Patients were contacted by phone, informed about the study, and data regarding their sociodemographic characteristics, medical histories, COVID-19 infection experiences, and medications used were collected. Comparative analyses (Fisher's exact test) and logistic regression tests were conducted.
The invention discloses a traditional Chinese medicine composition for treating constipation, and belongs to the technical field of a medicine for treating constipation. The traditional Chinese medicine composition is prepared from the following raw herbal materials, by weight part: 30-40 of rheum officinale, 45-60 of radix codonopsis, 30-40 of Chinese angelica, 15-20 of bighead atractylodes rhizome, 15-20 of radix astragali, 15-20 of pinellia ternate, 30-40 of immature orange fruit, 30-40 of magnolia cortex, 15-20 of dried orange peel, and 30-40 of senna leaf. The traditional Chinese medicine composition is scientific in compatibility, has the efficacy of clearing heat and moistening the intestines, relieving stuffiness and dispersing nodules, and boosting qi and nourishing blood, and has the efficacy of tonifying the kidney and boosting essence, nourishing yin and increasing humor, and moistening dryness and fortifying the spleen. The traditional Chinese medicine composition is a sustained release preparation, and the drug effect starts to be sustainably released after the traditional Chinese medicine composition enters the intestines. The traditional Chinese medicine composition can directly reach at a deep focus, adjusts the movement function of the stomach and intestines, and achieves the purpose of simultaneous treatment of principal and subordinate symptoms. The traditional Chinese medicine composition is good in curative effect without recrudesce, can be mildly administrated, has no side effect or drug dependence, and is particularly suitable for a patient, who suffers from constipation, is weak, and has an interior heat indigestion symptom.
Freezing of Gait (FoG) is a common symptom of Parkinson's disease (PD), manifesting as a brief, episodic absence, or marked reduction in walking, despite a patient's intention to move. Clinical assessment of FoG events from manual observations by experts is both time-consuming and highly subjective. Therefore, machine learning-based FoG identification methods would be desirable. In this article, we address this task as a fine-grained human action recognition problem based on vision inputs. A novel deep learning architecture, namely, higher order polynomial transformer (HP-Transformer), is proposed to incorporate pose and appearance feature sequences to formulate fine-grained FoG patterns. In particular, a higher order self-attention mechanism is proposed based on higher order polynomials. To this end, linear, bilinear, and trilinear transformers are formulated in pursuit of discriminative fine-grained representations. These representations are treated as multiple streams and further fused by a cross-order fusion strategy for FoG detection. Comprehensive experiments on a large in-house dataset collected during clinical assessments demonstrate the effectiveness of the proposed method, and an area under the receiver operating characteristic (ROC) curve (AUC) of 0.92 is achieved for detecting FoG.
A composition and method for vitalizing and stabilizing a cosmetic product, comprising: an inner cosmetic layer; and an outer shell including: metal ions; and an anhydrous cosmetic product. The metal ions are selected from the group consisting of: copper ions, silver ions, and gold ions. The concentration of the metal ions ranges from 2 ppm to 200 ppm. The two types of metal ions may be equal in concentration. Additionally, a composition for vitalizing and stabilizing cosmetics, includes: hydrophilic ions selected from the group consisting of copper ions, silver ions, and gold ions; and an anhydrous cosmetic product. The method includes: introducing hydrophilic ions into water substantially free of ions to form a solution; atomizing the solution; and combining the atomized solution with a cosmetic product. The method further includes inserting a pure sample of a desired element into the water substantially free of ions and running a current therethrough.
This will be a randomized, single blind study of 6 weeks duration involving the use of auricular acupuncture or sham acupuncture in the add adjunctive treatment of depression in college students. College students presenting for care at Counseling and Psychological Services, who meet Diagnostic and Statistical Manual of Mental Disorders - V (DSM-V) criteria for major depression single episode or recurrent will be included in the trial. Subjects will be randomized into a sham auricular acupuncture group, or a treatment acupuncture group. All subjects who meet the inclusion criteria will be treated with the Selective serotonin reuptake inhibitor (SSRI) Lexapro 10 mg daily which will be increased to 20 mg daily at week 2. Some subjects will be treated twice weekly during their follow-up visits with sham auricular acupuncture, some subjects will be treated with micro-currents of electricity in the auricular acupuncture group. The duration of the trial will be 6 weeks.

Auricular acupuncture is a form of acupuncture which utilizes the surface of the external ear to identify points of inflammation in the body. It does this, in this case, by utilizing the Pointer Excel II probe which can pick up a change in electrical conductivity on the surface of the ear, which reflects an internal point of inflammation or stress. Once the point of inflammation is identified, the Pointer Excel II is equipped with a sensor that it will not only illuminate by way of a small light on the front of the probe will also identify the point of inflammation by way of an auditory signal. Once the point of inflammation is identified auricular acupuncture will treat that point with a micro-current of electricity for several seconds. In the case of treatment, there will be an auditory alarm followed by a micro -current dose of electricity. Sham acupuncture will be characterized by the auditory alarm, but no current will be applied to the participants ear.
The intersection of cardiovascular disease, metabolic disorders and chronic kidney disease represents a complex clinical picture challenging healthcare systems worldwide. Metabolic-dysfunction-associated steatotic liver disease (MASLD) often manifests sequentially or concomitantly with these diseases, and may share underlying mechanisms and risk factors. Growing evidence suggests that new therapies could have benefits across these diseases, but trial sponsors and investigators tend to be reluctant to include patients with comorbidities-particularly liver diseases-in clinical trials. In this Perspective, we call for inclusion of patients with MASLD and measurement of liver outcomes in cardio-kidney-metabolic trials, when data suggest mechanistically plausible benefits and liver and cardiovascular safety. We discuss the implications of this new paradigm for clinical trial design and considerations for regulatory approval. Finally, we outline the challenges to implementing such an approach and provide recommendations for future clinical trial conduct.
Arm B will explore a 3 weekly schedule in which a single dose is administered every 3 weeks (1 cycle=21 days=1 treatment). The starting dose for Arm B will be the dose level below the Arm A level that provides an equivalent dose over a 3-week period.
BACKGROUND: Frailty is identified as the primary goal of preventing the various consequences. The present study aimed to assess validity and reliability of the Persian adapted version of the Tilburg frailty indicator (TFI) in Iran.
METHOD: This cross-sectional study included three phases of translating the indicator to Persian, assessing the face and content validity, completing the P-TFI by older people, who helped assess the reliability and construct validity. For construct validity, convergent and divergent validity were used. It was expected that the TFI domain scores would show the highest correlations with their related measures of frailty (convergent construct validity) and the lowest correlations with measures of the other domains (divergent construct validity). The study population consisted of 400 older people, selected from six health care centers.
RESULTS: The mean age of the participants was 69.05 ± 7.28 years and the majority of the participants were married woman with less than a high school education. The total mean score of TFI was 8.26 ± 1.80, and 42.75% was classified as frail. The test-retest reliability was 0.88 for the total scale, 0.80 for physical, 0.65 for psychological, and 0.81 for social domains. The mean score of frailty and its dimensions (physical, psychological, and social) varied from 4.35 ± 1.78, 1.81 ± 1.33, 1.69 ± 0.73, and 0.86 ± 0.61, respectively. The total score of the TFI was correlated with each alternative measure and the convergent validity was proved. Further, the kappa values ranging from 535 to 0.967 were significant and test- retest reliability for total, physical, psychological, and social dimension were 0.88, 080, 065, and 081, respectively. Further, the convergent or divergent validity is being discussed for clarity.
CONCLUSION: The Persian version of the TFI is valid and easy scored tools among Iranian's older people.
Participants will be instructed to take 17 grams of powder Polyethylene glycol 3350 (PEG) every day starting 3 days prior to scheduled surgery date and continue to take 17 grams of PEG every day for 7 days following the day of surgery. Participants will be allowed to titrate up or down the amount of PEG used as needed and instructed to record all doses of PEG used.
Acne vulgaris is an under-studied common genetic disease with tremendous economic consequences. Acne vulgaris is one of the most common skin conditions treated by doctors. It affects 40-50 million people in the USA, with prevalence as high as 85% (recent study from Iran was 93%) in teenagers; 18% of woman have late onset (\>25yr) acne vulgaris. Severe acne has a life-long psychosocial impact due to the significant scarring. Severe acne can also be associated with severe systemic inflammatory disease with fever, sterile osteomyelitis, inflammatory arthritis and other signs of systemic inflammatory responses. Some of these syndromes in Mendelian form (e.g. PAPA syndrome) have known genetic defects. Finally, while the data are inconclusive, there have been many suggestions that diet can exacerbate acne in some patients. The standard of care treatment for severe acne is systemic retinoid therapy, which, is usually, but not always effective. Unfortunately, systemic retinoid treatment is associated with significant toxicity, including common cutaneous adverse effects (dry lips, eyes, skin fragility), less common laboratory abnormalities such as elevated blood lipids, liver function abnormalities, and severe predictable teratogenicity. In addition, systemic therapy with retinoids has been associated with systemic diseases such as clinical depression, suicide, and inflammatory bowel disease, however the mechanisms and significance of these associations has not been determined. Given the frequency and severity of severe acne, the predictable severe toxicity of systemic retinoid therapy, and the already demonstrated genetic associations found in Mendelian forms of severe acne, it seems likely that significant genetic risk factors may be identified in patients with severe acne which would promote new and safer therapy, including dietary adjustment.
Transient global amnesia (TGA) is characterized by isolated sudden anterograde amnesia. Diffusion restriction can be observed in the hippocampus on DWI-MRI at varying rates in TGA patients. This study analyzes the prevalence and characteristics of the hippocampal diffusion restriction (HDR), its relationship with vascular risk factors, and the prevalence of lesions overlooked in routine reports. 91 patients diagnosed with TGA at a tertiary hospital between 2011 and 2022 were evaluated retrospectively. The mean age was 64.8 ± 7.3 years, and 63.7% of patients were female. 75.8% of the patients had at least one vascular risk factor. Focal diffusion restriction was detected in 17 patients (18.5%) on DWI-MRI, with only one being extra-hippocampal. 81.2% of HDR was detected when DWI-MRI scan was performed between 12 and 96 h after the onset of symptoms. HDR was detected most when the imaging was performed in 24 to 48 h (p = 0.03). There was no correlation between the duration of symptoms and the detection rates of HDR (p = 0.55). In 9 patients (53% of 17) diffusion restriction was not specified in routine radiology reports. Although focal ischemia, venous flow abnormalities, migraine and epileptic phenomena have been suggested in its etiology, TGA is a clinical condition of which pathophysiology has not been determined clearly. Signal changes observed in DWI-MRI has led to discussions that cerebrovascular etiology may play a role, yet more comprehensive studies are required to prevent and manage TGA. HDRs can be overlooked in routine reports. Therefore, the DWI-MRI images of patients with TGA should be examined vigilantly.
PROBLEM TO BE SOLVED: To provide an apoptosis-inducing peptide capable of selectively inducing the apoptosis of cells such as cancer cells and autoimmune T-cells, and further to provide a method for screening the peptide and an apoptosis-inducing agent containing the peptide. SOLUTION: This apoptosis-inducing peptide comprises one of 38 kinds of synthetic amino acid sequences, and can induce a characterizing form of the apoptosis to a target cell. The apoptosis inducing peptide contains the sequence, and composed of 6-9 continuous amino acid residues. The method for screening the apoptosis-inducing peptide comprises (a) bringing a target cell into contact with at least one kind of a peptide bead, and (b) detecting the presence or absence of the apoptosis in the target cell obtained in the step (a). The apoptosis-inducing peptide obtained by the method is also provided. The method for producing the apoptosis-inducing agent comprises joining the apoptosis inducing peptide with a pharmacologically acceptable insoluble carrier. The apoptosis inducing agent is also provided.
Lurasidone hydrochloride tablets should be taken with food (at least 350 calories). Administration with food substantially increases the absorption of lurasidone hydrochloride. Administration with food increases the AUC approximately 2-fold and increases the Cmax approximately 3-fold. In the clinical studies, lurasidone hydrochloride tablets were administered with food [see Clinical Pharmacology (12.3)].

The effectiveness of lurasidone hydrochloride tablets for longer-term use, that is, for more than 6 weeks, has not been established in controlled studies. Therefore, the physician who elects to use lurasidone hydrochloride tablets for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient [see Dosage and Administration (2.1 and 2.2)].