anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Cough reflex testing (CRT) is an adjunct to the clinical swallowing evaluation (CSE), providing information on patients' risk of silent aspiration. CRT has been shown to influence diet recommendations, but in previous work, the many varied patient characteristics are not controlled. Therefore, the specific role of CRT results in these decisions remains unclear as this relationship has not been directly assessed.
METHOD: An online survey was sent to speech language therapists working in dysphagia. Two patient cases were presented that differed only by the presence of risk factors for the development of aspiration pneumonia. For each patient case, there were three assessment scenarios: CSE information only, CSE information with a "pass" CRT result, and CSE information with a "fail" CRT result. Clinicians outlined their patient management plans for each of the six scenarios.
RESULTS: Ninety-seven data sets were used in the final analysis. A "fail" result was found to lead to the most restrictive patient management. Decisions made when provided with only CSE information were very similar to decisions made for a CSE with a "pass" result. Aspiration pneumonia risk factors were shown to influence decision making, with the low-risk patient more likely to be recommended a less restrictive diet.
CONCLUSIONS: When information was available regarding silent aspiration risk, clinicians factored the results into their decision making. However, in the absence of a CRT result, airway sensation was assumed to be intact in the absence of information. This finding warrants further investigation given the impact this assumption may have on a patient's pulmonary health.
A composition for preventing and treating Th-2 mediated immune diseases, which contains probiotics as an active ingredient is provided to induce hypo responsiveness and treat Th2 cell-mediated diseases by reducing Th2 immune response. A food composition for treating allergic disease or a pharmaceutical composition for preventing and treating allergic disease comprises probiotics as an active ingredient. The probiotics comprises Bifidobacterium bifidium, Lactobacillus reuteri, Lactobacillus acidophilus, Streptococcus thermophilus, and Lactobacillus casei. The allergic disease is atopic dermatitis. The daily dose of the pharmaceutical composition is 0.001-2000 mg/kg(weight). The composition is used in a form of solution in oil or aqueous media, suspension, powder, granule, tablet, or capsule.
The STAK Tool enables patients to apply a high intensity stretch to their knee independently. Patients are asked to do this for a maximum of 60 mins per day.
The invention discloses a preparation method of a monkshood paste formula. The prepared traditional Chinese medicine is boiled out, subjected to deslagging and concentrated to be paste. Patients belonging to yang-deficiency constitution become better after taking the decoction using monkshood as the primary medicine, but still need to take the prescription. 6-10 doses of prescription adding tortoise-plastron glue and deer-horn glue are used as the plaster material to prepare monkshood paste suitable for patients after the procedures of decocting tag, decocting spices, taking juice and concentrating, gluing, adding auxiliary materials, receiving paste and packaging. The small-bag monkshood paste can be preserved for 3 months at normal temperature and 1 year in a refresh-care layer of a refrigerator. Particularly, the problem of toxicity of monkshood troubling both patients and doctors is favorably solved, the safety effectiveness of taking monkshood for a long time is ensured, the characteristic of one people one formula in the traditional Chinese medicine is embodied completely, and long-time expectant treatment is directionally carried out on patients suffering from heavy cold.
FIELD: medicine. SUBSTANCE: the innovation describes peptides of the A-D-X-Mrp-B general formula and, also, their additive salt with pharmaceutically acceptable organic or inorganic acids, where A, D, X or B substitutes have got the values mentioned in the description. The compounds obtained are able to activate the growth hormone releasing. This activity is improved due to peroral intake of these compounds. EFFECT: higher efficiency. 13 cl, 1 tbl, 5 ex
BACKGROUND: Low molecular weight heparin has proven to be safe and effective but is not without potential risks such as spontaneous bleeding in the abdominal cavity. There is limited evidence evaluating the true incidence of this potential risk and the available literature is primarily via case reports.
CASE SUMMARY: The purpose of this study was to identify the incidence and risk factors associated with enoxaparin use (prophylaxis or treatment) abdominal hematomas in a 350-bed community hospital during an 8-month time period. A total of 44 patients were identified as clinically significant bleeds receiving enoxaparin treatment or prophylactic therapy. Ultimately, 25 patients were excluded from the analysis due to an external cause of the abdominal hematoma or a temporal mismatch in enoxaparin administration and hematoma formation. After exclusion, there were a total of 19 patients that were assessed for the risk factors such as age, gender, renal function, and weight. After evaluation of risks, over half of the patients developing a clinically significant bleed were considered elderly (>65 years of age) and impaired renal function with a creatinine clearance of 60ml/min or less.
CONCLUSION: Patients at risk for an enoxaparin associated hematoma include female patients with a CrCl <60ml/min and/or BMI >30 kg/m2 receiving enoxaparin treatment dosing.
A data processing installation (14) has a display unit (38), interface (24), and an evaluation unit (26). A fine identification unit (12) has a support (16) for placing the medical instruments, and a camera (18). The camera is oriented such that it can capture the image data of medical instruments from one perspective. The evaluation unit compares the image data with already stored image data of instruments, and visually identifies a respective instrument. The instruments are combined to form a set of instruments following the visual identification in the fine identification unit. An independent claim is included for a method for assembling sets of medical instruments.
The organoleptic properties (partic. smell, flavour and tenderness) of meat from non-castrated male animals are improved shortly before slaughter by suppressing the action of androgenic and non-androgenic steriods by active or passive immunisation with anti-LHRH. The advantages associated with the male characters of the animal are retained practically up to the time of slaughter. Also new are (1) the peptide of formula (I) Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (I) (2) conjugates (A) of the with an immunogenic carrier protein; and (8) anti-LHRM vaccines contg. (A) or an alpha-globulin/LHRH conjugate. Specifically the animal is given a first injection of vaccine, pref. during the fattening stage, to induce a low level immune response which has no appreciable effect on gonadal steroids, then just before slaughter additional vaccine is administered to suppress (or significantly reduce) steroid secretion without adverse localor general reactions which could harm the appearance or quality of the meat.
Participants diagnosed with hypoxia negative human papilloma virus (HPV) associated oropharyngeal carcinoma (OPC). Participants in Cohort B will receive 1 cycle of carboplatin and Paclitaxol the same week of the start of radiation. Paclitaxel can be substituted with Abraxane (Albumin-bound Paclitaxel). Paclitaxel can be substituted with Abraxane and the dose will be 50mg/m\^2. For Cohort B, patients over 70yrs will be able to enroll regardless of Cisplatin or carboplatin/5-fluorouracil (FU) eligibility.
Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders. In individuals with MPS disorders, have deficiency or malfunction of specific lysosomal enzymes leads to an abnormal accumulation of certain complex carbohydrates (mucopolysaccharides or glycosaminoglycans) in the arteries, skeleton, eyes, joints, ears, skin, and/or teeth. These accumulations may also be found in the respiratory system, liver, spleen, central nervous system, blood, and bone marrow. This accumulation eventually causes progressive damage to cells, tissues, and various organ systems of the body. Due to such an extreme variability in clinical presentation as well as wide range of disease spectrum, but insufficient MPS disease awareness in Taiwan, these resulted in a delay diagnosis or even miss diagnosis with other clinical symptom thus patient often received inappropriate treatment. In order to address the current issue of delay diagnosis among MPS patient, it is critical to develop a MPS screening algorithm for high risk patients in Taiwan.
Chronic kidney disease (CKD) is among the leading causes of death and disability, affecting an estimated 800 million adults globally. The underlying pathophysiology of CKD is complex creating challenges to its management. Primary risk factors for the development and progression of CKD include diabetes mellitus, hypertension, age, obesity, diet, inflammation, and physical inactivity. The high prevalence of diabetes and hypertension in patients with CKD increases the risk for secondary consequences such as cardiovascular disease and peripheral neuropathy. Moreover, the increased prevalence of obesity and chronic levels of systemic inflammation in CKD have downstream effects on critical cellular functions regulating homeostasis. The combination of these factors results in the deterioration of health and functional capacity in those living with CKD. Exercise offers protective benefits for the maintenance of health and function with age, even in the presence of CKD. Despite accumulating data supporting the implementation of exercise for the promotion of health and function in patients with CKD, a thorough description of the responses and adaptations to exercise at the cellular, system, and whole body levels is currently lacking. Therefore, the purpose of this review is to provide an up-to-date comprehensive review of the effects of exercise training on vascular endothelial progenitor cells at the cellular level; cardiovascular, musculoskeletal, and neural factors at the system level; and physical function, frailty, and fatigability at the whole body level in patients with CKD.
Many studies have shown that a brief motivational interview in the context of a routine or emergency health care visit may assist adults to reduce high-risk drinking and drug-taking. Center researchers are conducting a 1,400-person, randomized clinical trial involving teen patients at the Boston Medical Center Pediatric Emergency Department in order to determine if a similar approach will be effective with youth. All patients aged 14 to 21 get a brief alcohol and drug screen, and those whose scores indicate they drink or use marijuana are invited to participate in the study. One-third of the enrollees will receive an assessment, a brief motivational interview performed by a trained peer counselor, direct referrals to community-based resources for adolescents, and a 10-day follow-up phone call. One-third will receive only the assessment and a list of community resources; and the final third will receive only the list of resources. All participants will be followed over time and re-screened to measure the impact of the initial brief intervention on their drinking and drug-taking. The key hypothesis is that individuals who receive the brief motivational interview in the emergency department setting will have lower rates of alcohol and illicit drug use and fewer health consequences over time.
Epileptic nystagmus (EN) is a subtle seizure semiology, most commonly seen in seizures originating in the posterior cortical regions. EN is broadly categorized into type I and type II. Type I EN consists of contralateral repetitive saccadic eye movements alternating with post-saccadic slow drifts with an overall contralateral deviation. Type II EN is characterized by ipsilateral slow drift alternating with contralateral corrective saccades. In this article, we report a method to perform oculographic analysis of eye movements using EEG only. We used this method to classify the type of EN in three patients with parieto-occipital seizures. In all three patients, the ictal EEG demonstrated repetitive saccadic eye movements, directed contralateral to the seizure onset zone. With prolonged time constant, we were able to identify this eye movement pattern as EN with distinct slow and fast phases. We were able to further characterize the type of EN as type I and type II. In all three patients, the direction of EN (direction of fast phase or saccades) was contralateral to the seizure onset zone. EN can be easily missed on video-electroencephalography (vEEG) recordings because of various reasons. Our study demonstrates a systematic method of eye movement analysis on EEG, which can be used to not only identify EN as seizure semiology but also classify it, without requiring additional electrodes.
The invention belongs to the technical field of medicine, and discloses a medicinal composition for treating infant oral ulcer. The medicinal composition is prepared from gentamicin sulfate, prednisone acetate, vitamin C, vitamin B1, vitamin B2, niacinamide, vitamin B6 and watermelon frost as raw materials according to different characteristics of the component medicinal raw materials and proportion. The raw materials are dried at low temperature, porphyrized, mixed well, sterilized and so on to prepare a powder agent or a spraying agent. The medicinal composition is characterized by new formula, convenience in preparation and obvious effect. The raw materials for preparing the drug are wide in source of feed and low in cost, so that the cost of the drug is reduced. Clinically proved by 200 more cases of infant oral ulcer patients, the efficiency rate is up to 100%, and no special toxic and side effect is shown.
National recommendations state that patients with a history of transient ischemic attack (TIA) or ischemic stroke should receive hypertension treatment, including antihypertensive medication and lifestyle modification, with a goal of reducing blood pressure (BP) to \<120 mm Hg systolic BP and \<80 mm Hg diastolic BP. Statin treatment and lifestyle modification is also recommended for post-stroke and post-TIA patients with elevated cholesterol levels or a history of stroke or TIA with an atherosclerotic cause. Despite the clear benefits of secondary stroke prevention, there is a gap between evidence and implementation in clinical practice. We will determine whether a telephone-delivered behaviorally tailored intervention (TI) can lead to sustained change resulting in (a) BP and lipid control and (b) improved adherence to diet, medication, and exercise recommendations in veterans with a history of stroke or TIA compared to an attention placebo (AP) in veterans who have completed 6 months of a clinical trial. In this CDA project, we evaluate the long-term effectiveness of booster sessions in a randomized manner. One arm will receive 6 months of a tailored intervention (TI) followed by two booster TI sessions at 8 and 10 months, and one arm will receive 6 months of an attention placebo (AP) followed by two booster AP sessions at 8 and 10 months. BP (3 measures taken at least 5 min apart) and dietary sodium are the primary outcomes, while secondary outcomes will be total cholesterol/high density lipoprotein ratio, adherence to antihypertensive and lipid-lowering drugs, and exercise adherence.
Biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, opthamological or urological disorders are provided as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In another embodiment a method to reductively cleave the osmate(VI)ester avoiding the use of gaseous H 2 S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems.
The present invention relates to health food, particularly to a female cigarette type vanilla smoking product. The present invention uses ginkgo leaves, pyrola, etc., as main materials, and argyi leaves, loquat leaves, honeysuckle flowers, glycyrrhiza, etc., are added. A female cigarette type smoking product is designed according to female characteristics. The present invention has the advantages that the taste is clean, mellow and comfortable, and the aftertaste is clean and comfortable. When the present invention is always smoked, the present invention has the functions of relieving a cough, eliminating sputum, sterilizing, resisting viruses and restoring consciousness, and has the functions of preventing respiratory tracts and middle and old aged people's common disease symptoms. The epithelial cell regeneration can be promoted, the growing mechanism is maintained and promoted, and the present invention has the functions of promoting blood circulation, restoring menstrual flow, promoting urination, removing edema, etc. The effect of the present invention is obvious in the ways of regulating female irregular menstruation, dysmenorrhea, amenorrhea, persistent lochia, leukorrhagia, urinary tract infection, etc., and simultaneously, the present invention has the functions of skin beautification and senility delay.
The invention discloses a sericite/nano-zinc oxide composite material and a preparation method thereof. The composite material is characterized in that the surface of sericite powder is coated with nano-zinc oxide. The preparation method comprises the following step: adding calcium hydroxide or calcium oxide into a mixed system of the sericite powder and zinc sulfate solution so as to directly obtain the nano-zinc oxide coated sericite powder composite material. According to the method, the sericite which is taken as a base material is a natural mineral, so that the raw material is easily available, free of pollution and low in cost; the preparation process is simple, safe, reliable and easy to control; the obtained composite material is stable in quality, and has the good dispersibility in an organic solvent and also has the excellent ultraviolet resistance and the excellent antibacterial and deodorant performance. Thus, the composite material can be applied to the field of coatings, cosmetics and the like. The method has a good potential application value in the field of synthesis of the composite material or other related sciences.
The present invention provides adipose-derived stem cells (ADSCs}, adipose-derived stem cell-enriched fractions (ADSC-EF} and adipose-derivedlattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the gro∩ and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
BACKGROUND: Neck muscle vibration decreases pain and improves sensorimotor impairments in patients with chronic neck pain. However, the impact of placebo on these effects are still unclear.
OBJECTIVE: The aim was to evaluate the effect of neck muscle vibration compared to placebo neck muscle vibration in patients with chronic neck pain.
METHODS: Twenty-three people with chronic neck pain participated in this double-blinded, randomized crossover study. After baseline assessment at day 1, patients received either neck muscle vibration or placebo neck muscle vibration at day 2. At day 3, patients underwent the other treatment. The primary outcomes assessed at each day were active cervical joint position sense acuity, resting pain, and pressure pain threshold.
RESULTS: Cervical joint position sense revealed a significant time effect (F1, 22 = 4.366, p = 0.016, η2 = 0.902). Post-hoc testing revealed significant increases in cervical joint position sense after neck muscle vibration (p = 0.023; d = 0.602) but not after placebo vibration. Resting pain (F1, 22 = 7.550, p = 0.003, η2 = 0.418) displayed significant time effects for neck muscle vibration and placebo vibration. Pressure pain threshold demonstrated a significant time to condition effect (F1, 22 = 6.146; p = 0.008, η2 = 0.369). Post-hoc tests revealed that only neck muscle vibration significantly increased pressure pain threshold (p = 0.043, d = 0.516).
CONCLUSION: The study demonstrates the efficacy of neck muscle vibration to decrease neck pain and improve cervical joint position sense in patients with chronic neck pain. Nevertheless, the influence of placebo effects should not be underestimated as they may contribute to these effects, indicated by similar decreases in resting pain.
Zumandimine contains 3 mg of the progestin DRSP, which has anti-mineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to a 25 mg dose of spironolactone. Zumandimine is contraindicated in patients with conditions that predispose to hyperkalemia (that is, renal impairment, hepatic impairment, and adrenal insufficiency). Women receiving daily, long-term treatment for chronic conditions or diseases with medications that may increase serum potassium concentration should have their serum potassium concentration checked during the first treatment cycle. Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin–II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs. Consider monitoring serum potassium concentration in high-risk patients who take a strong CYP3A4 inhibitor long-term and concomitantly. Strong CYP3A4 inhibitors include azole antifungals (e.g. ketoconazole, itraconazole, voriconazole), HIV/HCV protease inhibitors (e.g., indinavir, boceprevir), and clarithromycin [see Clinical Pharmacology (12.3)].