anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Prior studies have shown that people with aphasia (PWA) have demonstrated superior language performance for emotional compared to nonemotional stimuli on a range of tasks, including auditory comprehension, verbal pragmatics, repetition, reading, and writing. However, studies on word retrieval, specifically, have suggested a possible interference effect of emotion on naming. The purpose of this study was to examine the effect of the emotional valence of stimuli on word retrieval in a series of naming tasks in PWA.
METHOD: Thirteen PWA and 13 neurotypical controls participated in four single-word naming tasks, including 1) object picture naming, 2) action picture naming, 3) category-member generation, and 4) verb generation. Each task included three valence sets of positively-, negatively-, and neutrally-rated pictures or words, which were obtained from the standardized International Affective Picture System (Lang et al., 2008) and the Affective Norms for Emotional Words (Bradley and Lang, 1999) databases. Accuracy and reaction time (RT) were measured and compared across groups, tasks, and valence sets.
RESULTS: Emotional stimuli, especially negative stimuli, resulted in worse naming performance, as measured by accuracy and RT, compared to nonemotional stimuli in PWA and neurotypical controls. This effect was relatively robust across the four naming tasks. In most cases, negative stimuli resulted in lower accuracy and slower RT than positive stimuli.
CONCLUSIONS: These findings suggest that stimulus valence may interfere with word retrieval for PWA and neurotypical adults and that this effect is robust across different types of naming tasks that vary by word class (nouns versus verbs) and stimulus type (pictures versus words). Negative stimuli resulted in worse naming performance than positive stimuli. These results suggest that emotionality of stimuli is an important variable to consider in word retrieval research.
The current malaria vector control tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are critically important and have saved many lives. However, their effectiveness in western Kenya is threatened by insecticide resistance and vector behaviour changes toward more early evening and outdoor biting malaria vectors. LLINs and IRS specifically target indoor-biting and indoor-resting mosquitoes. Malaria vectors exhibit different behavioural characteristics that mitigate the effectiveness of vector control strategies. For example, traditionally, An. gambiae s.s. has been regarded as human-biting with late-night indoor-feeding and indoor-resting behaviours, while An. Arabiensis is found more often in drier environments and is more zoophagic with outdoor biting and resting behaviours. Following LLINs and IRS's widespread scale-up, the dominant African vectors' distributions and behaviours changed with An. gambiae s.s. and An. Funestus (also an indoor human biter) diminishing in abundance relative to An. arabiensis. Subsequently, shifts towards earlier evening biting by An. Gambiae s.s. (before people enter houses to sleep under LLINs) and later biting by An. Funestus (biting in the morning after sunrise) are examples of behavioural plasticity enabling these species to avoid contact with the LLIN and IRS insecticides.

There is a need for interventions that supplement and complement LLINs and IRS by killing mosquitoes outside houses using other biologic mechanisms (e.g., targeting sugar feeding behaviour). Furthermore, insecticides are required with novel modes of action that may restore sensitivity to pyrethroids by killing both pyrethroid-resistant and sensitive mosquitoes. Attractive Targeted Sugar Bait (ATSB) (the name was recently changed from Attractive Toxic Sugar Bait to highlight that it targets malaria vectors) is a promising new intervention that potentially fills the need for outdoor interventions with novel killing effects.

ATSB 'bait stations' are A4-sized panels containing thickened fruit syrup laced with a neonicotinoid insecticide (dinotefuran) to attract and kill the foraging vectors. Entomological field trials in Mali showed that ATSBs successfully reduce mosquito densities and longevity and thus have the potential to reduce malaria transmission. Large scale efficacy studies are now needed to establish the efficacy of ATSB for controlling malaria transmission.
Abdominoplasty is one of the most commonly performed procedures in plastic surgery. The appearance of the scar is a major factor contributing to the aesthetic outcome of the procedure and depends largely on the technique of wound closure. The new PrineoTM wound closure system was introduced to combine the effectiveness of 2-octyl-cyanoacrylate (Dermabond TM) together with a self-adhering mesh.Fifty-two women and 8 men aged between 21 and 65 years scheduled for abdominoplasty were included in the study. Two weeks postoperatively, the wounds were examined and graded according to the Hollander Cosmesis Scale. At 3- and 6-month follow-up, the aesthetic outcome of the abdominal scar was evaluated with the Vancouver Scar Scale. Six months postoperatively, the patients were further asked to score their part of the Patient Scar Assessment Scale.The Hollander Cosmesis Scale indicated a significantly more favourable overall result with PrineoTM at 2 weeks after surgery. The Vancouver Scar Scale demonstrated a better cosmetic outcome in favour of PrineoTM 3 and 6 months after surgery The Patient Scar Assessment Scale scores 6 months after surgery indicated that the patients noted significantly less pain, thickness and irregularity with PrineoTM.Based on the investigators results, the investigators conclude that PrineoTM is a safe and effective substitute for superficial skin closure, with good cosmetic results and no increase in wound complications. The use of PrineoTM decreases operative times and enhances patients' postoperative comfort
PURPOSE:To provide a bathing agent so designed that prior to plunging it into bath water, its color after dissolved in the bath water cannot be determined, thus bearing unexpectedness in terms of visual sense and visually enjoyable for its users before and after bathing. CONSTITUTION:The objective bathing agent containing at least two kinds of coloring matter-contg. material group, i.e., (A) the 1st coloring matter-contg. material group having at least one kind of coloring matter and (B) the 2nd coloring matter-contg. material group having at least one kind of coloring matter differing from the above coloring matter and giving color differing from that of the 1st group in terms of visual sense prior to plunging into bath water. For this bathing agent, the above at least two kinds of coloring matter- contg. material groups are formulated so as to have the above color effect by regulating the levels of the respective coloring matters and optimizing e.g. a vehicle.
NEW MATERIAL:A benzimidazole derivative sown by the formula I (R1 and R2 are H, or lower alkyl; R3 is H, or lower alkoxy). EXAMPLE:2-(2-Aminobenzylthio)benzimidazole. USE:Useful as an antitumor agent. Showing improved suppressing action on secretion of acid in the stomach by inhibitory action on H<+>+K<+>ATPase. PREPARATION:A 2-mercaptobenzimidazole shown by the formula II is reacted with a 2-aminobenzyl compound shown by the formula (X is reactive group) in an inert solvent such as toluene, etc. at room temperature - under reflux, more preferably in the presence of an alkalizing agent such as NaOH, etc., to give a compound shown by the formula IV. The, this compound shown by the formula IV is oxidized to give a compound shown by the formula I. In oxidation of the compound shown by the formula IV, an oxidizing agent such as hydrogen peroxide, etc. is used, and the oxidation is carried out in an inert solvent such a chloroform, etc. at -30-50 deg.C.
Background: The role of diet on the risk of chronic pancreatitis (CP) is understudied. The health benefits of the Mediterranean diet (MedDiet) pattern have long been recognized, but its association with CP risk is unclear. We aimed to investigate the association between adherence to MedDiet and the incidence of CP in a large-scale cohort. Methods: 190 790 participants from the UK Biobank were involved, all free of CP and with typical diet recall data at recruitment. The diagnosis of CP was ascertained by the combination of hospital inpatient data, primary care data, and death registry data. Multivariable Cox regression models were used to evaluate the associations between MedDiet adherence, measured by the Mediterranean Diet Adherence Screener (MEDAS) continuous score, and the incidence of CP. The mediating role of inflammation (assessed by C-reactive protein) and metabolic status between MedDiet adherence and CP risk was also investigated. Results: During a mean of 10.8 years of follow-up, 214 participants developed CP. Individuals with the highest adherence to MedDiet, defined by continuous MEDAS scores, exhibited significantly lower risk of developing CP (hazard ratio [HR] = 0.57, 95% confidence interval [CI]: 0.40-0.82; p = 0.002) compared to those in the lowest tertiles. Metabolic status mediated 4.74% of the association between MedDiet adherence and CP risk, while the mediating role of C-reactive protein was not significant. Conclusion: Greater Mediterranean diet adherence is associated with reduced chronic pancreatitis risk.
BACKGROUND: Pneumococcal meningitis (PM) triggers apoptotic neuronal and progenitor cell death in the hippocampal dentate gyrus (DG), resulting in subsequent cognitive impairment. Microglia play a crucial role in PM-induced hippocampal damage. While the lasting effects of neonatal nutrition on health are well documented, the influence of early-life overfeeding on the host response to neuroinfections remains uncertain. This study aimed to examine whether neonatal overfeeding affects the outcome of PM in the hippocampus (HC).
MATERIAL AND METHODS: Overfeeding was induced by adjusting litter size immediately after birth. On the eleventh day of life, rats were intracisternally injected with Streptococcus pneumoniae or saline, followed by euthanasia after 24 hours for brain dissection. Histological analysis evaluated apoptosis in the DG and the extent of inflammatory infiltrate in the hippocampal fissure, while microgliosis was assessed by immunohistochemistry. The hippocampal transcriptome was analyzed using RNAseq, and the mRNA levels of specific inflammatory biomarkers were evaluated via RT-qPCR.
RESULTS: Overfed rats exhibited 40.5% greater body mass compared to their normal-fed counterparts. Intriguingly, PM-induced apoptosis in the DG was 50% lower in overfed rats. This effect was accompanied by significant alterations in the hippocampal transcriptional profile, particularly the lack of activation of the Programmed cell death pathway in overfed infected animals. RT-qPCR analysis of Aif1 and examination of Iba1-immunostained cells revealed mild microgliosis in the HC of infected-overfed animals. This reduced microglial reaction may be attributed to the diminished activation of interferon signaling pathways, as disclosed by the transcriptome analysis, potentially preventing microglial priming. Additionally, evidence of reduced neuroinflammation in overfed rats with PM was observed through the milder activation of pathways associated with Toll-like receptors, interleukins, and chemokine signaling. Furthermore, overfed animals exhibited increased transcription of proinflammatory Il6 and anti-inflammatory Il10 genes, with the latter showing higher expression even in the absence of PM, suggesting a priming effect of overfeeding on hippocampal immune cells.
CONCLUSION: This study sheds light on the complex interplay between early-life overfeeding, immune response, and neuroprotection in infant rats with PM. The findings demonstrate the neuroprotective impact of early-life overfeeding in the context of PM, linked to the modulation of microglial function.
PURPOSE:To obtain a foamable bath agent, having improved storage stability, and capable of evolving fine gaseous carbon dioxide for a long time in use in short steps, by granulating a carbonate which is a gaseous carbon dioxide source, an aminocarboxylic acid which is a gaseous carbon dioxide producing agent and a binder with an organic solvent added thereto. CONSTITUTION:A foamable bath agent obtained by mixing a carbonate, e.g. Na2CO3 or NaHCO3, which is a gaseous carbon dioxide source with an aminocarboxylic acid, e.g. N(CH2COOH)3 or (HOOCH2)2-N-CH2CH2-N(CH2COOH)2, as a gaseous carbon dioxide producing agent and a binder, e.g. PEG or PVA, and kneading and granulating the resultant mixture with an organic solvent, e.g. CH3OH or C2H5OH, thereto. The aminocarboxylic acid has improved storage stability even by mixing and granulating with the carbonate in the presence of a binder soluble in an organic solvent as opposed to the conventional organic acid, and is found to give the aimed foamable bath agent without any trouble.
PURPOSE: Changes in the cross-sectional area (CSA) and functional cross-sectional area (FCSA) of the lumbar multifidus (MF) and erector spinae muscles (ES) are factors that can contribute to low back pain. For the assessment of muscle CSA and composition there are various software and threshold methods used for tissue segmentation in quantitative analysis. However, there is currently no gold standard for software as well as muscle segmentation. This study aims to analyze the measurement error between different image processing software and different threshold methods for muscle segmentation.
METHODS: Magnetic resonance images (MRI) of 60 patients were evaluated. Muscle CSA and FCSA measurements were acquired from axial T2-weighted MRI of the MF and ES at L4/L5 and L5/S1. CSA, FCSA, and FCSA/CSA ratio were measured independently by two observers. The MRI images were measured using two different software programs (ImageJ and Amira) and with two threshold methods (Circle/Overlap method) for each software to evaluate FCSA and FCSA/CSA ratio.
RESULTS: Inter-software comparisons revealed high inter-rater reliability. However, poor inter-rater reliability were obtained with different threshold methods. CSA, FCSA, and FCSA/CSA showed excellent inter-software agreement of 0.75-0.99 regardless of the threshold segmentation method. The inter-rater reliability between the two observers ranged between 0.75 and 0.99. Comparison of the two segmentation methods revealed agreement between 0.19 and 0.84. FCSA and FCSA/CSA measured via the Overlap method were significantly higher than those measured via the Circle method (P < 0.01).
CONCLUSION: The present study showed a high degree of reliability with very good agreement between the two software programs. However, study results based on different threshold methods should not be directly compared.
The invention relates to the technical field of biological medicines, in particular to application of hard lump clearing granules in preparation of medicines for treating lower limb ischemia. The hard lump-softening and vein-clearing particles obviously improve the blood perfusion of mice with lower limb ischemia and increase the blood vessel density in gastrocnemius of the mice. The hard lump clearing particles inhibit the expression of STAT1mRNA and improve the expression of HIF-1 alpha mRNA and VEGFmRNA. The hard mass vein clearing granule inhibits the expression of STAT1 and pSTAT1, and reduces the ratio of pSTAT1 to STAT 1. The hard lump cleaning particles obviously improve protein expression of HIF-1 alpha and VEGF. Elisa test shows that the hardness softening and vein clearing particles increase the levels of VEGF, EGF and Ang1 in the gastrocnemius of mice. The hard mass softening and pulse clearing granule can inhibit STAT1 transcriptional activity, inhibit STAT1 phosphorylation, promote HIF-1 alpha transcriptional activity, improve expression of angiogenesis factors such as VEGF and the like, promote angiogenesis in lower limb ischemia muscle tissues, and improve blood flow perfusion of lower limbs.
Extensive dose range and dose adjustment studies with this drug product in normal and special populations have not been completed. In pediatric patients with epilepsy, doses given have been as low as 2.6 mCi.

The pharmacokinetics of Fludeoxyglucose F 18 Injection in renally-impaired patients have not been characterized. Fludeoxyglucose F 18 is eliminated through the renal system. Care should be taken to prevent excessive and unnecessary radiation exposure to this organ system and adjacent tissues. The effects of fasting, varying blood sugar levels, conditions of glucose intolerance, and diabetes mellitus on Fludeoxyglucose F 18 distribution in humans have not been ascertained. Diabetic patients may need stabilization of blood glucose levels on the day before and on the day of the Fludeoxyglucose F 18 Injection study.
The HIV infection does not leave lifelong immunity, but leads to break down of the immune system, opportunistic infections and death. The immunity obtained by the infection itself can only partially contain the HIV infection. The purpose with a targeted therapeutic vaccination is therefore in addition to the existing immunity to induce a broader, more powerful and more rationally or better directed immunity than the one induced by the "natural" HIV-1 infection. This would potentially lower the viral load in the blood making it more difficult to spread the virus to others and prolong the time to AIDS disease and medical treatment. There is a need for new rational vaccination possibilities, able to prevent (HIV) disease, postpone the need for antiretroviral medical treatment, prolong the life, and limit spread of HIV-1 in the population. The present protocol seak to introduce such a new immune treatment principle for HIV-1 infected individuals. In this study, individuals with chronic HIV-1 infection will be vaccinated with selected synthetic HIV immune-peptides representing new discovered conserved target´s on the virus. The vaccine should induce new immunity against several epitope targets on their HIV, whereby the HIV infection may be controlled for a longer time by the immune system. The purpose of the study is primarily to evaluate the safety and tolerability of the vaccine and secondary to evaluate the immunological and antiviral response in the vaccinated individuals.
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the glycoprotein backbone. According to one embodiment, this invention relates to methods for concentrating proteins that have been modified by carbohydrates and for releasing their activity at controlled rates. This invention also provides methods for producing carbohydrate crosslinked glycoprotein crystals and methods for using them in pharmaceutical formulations, vaccines, immunotherapeutics, personal care compositions, including cosmetics, veterinary pharmaceutical compositions and vaccines, foods, feeds, diagnostics, cleaning agents, including detergents and decontamination formulations. The physical and chemical characteristics of carbohydrate crosslinked glycoprotein crystals render them particularly useful as sorbents for separations, such as chiral chromatography, or affinity chromatography-which are based on specific interactions between the active binding site of the glycoprotein component of the crystals and the substance or molecule of interest. Such characteristics also render carbohydrate crosslinked glycoprotein crystals useful as catalytic and binding components for the production of biosensing devices.
Biological aging is associated with the loss of skeletal muscle mass and strength resulting in compromised metabolic function and mobility. Throughout life, individuals will also experience periods of reduced physical activity/muscle disuse that independently lower muscle mass and strength accelerating the aging process. More importantly, older adults (especially older women) that experience periods of muscle disuse are unable to recover muscle mass and strength. The losses in muscle mass with aging and disuse are underpinned by feeding-induced declines in rates of muscle protein synthesis. Thus, strategies to enhance muscle protein synthesis could have clinical implications for those who wish to maintain metabolic health and function during times of muscle disuse.

Supplementation with n3 PUFA-enriched fish oil has been shown to potentiate rates of muscle protein synthesis in response to simulated feeding in both younger and older adults. Fish oil supplementation also has been efficacious in enhancing skeletal muscle strength during a period of resistance exercise training. A previous study from our group demonstrated that younger women supplementing with n3 PUFA-enriched fish oil attenuated declines in skeletal muscle mass and strength during 2 weeks of immobilization. However, no study has examined the impact of fish oil supplementation to enhance muscle protein synthesis and offset declines in muscle mass/strength during a period of immobilization in older women.
<P>PROBLEM TO BE SOLVED: To obtain a hair growing tonic composition/anti-depilatory agent composition affording high hair growing tonic/anti-depilatory effects without causing adverse effects.  <P>SOLUTION: The hair growing tonic composition comprises an extract from a peanut seed pellicle as a principal ingredient. The hair growing tonic composition further comprises one or two or more kinds of extracts selected from the group consisting of Polygonum multiflorum Thunb., Artemisiae princeps Pamp., Swertia japonica Makino, Houttuynia cordata Thunb. and Glycyrrhiza glabra L. var. glandulifera Regel et Herder as an accessory ingredient.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
A method for the chemoradiotherapy of lung small cell disseminated carcinoma comprises the chemotherapy, which is carried out by intravenous drop-by-drop introduction of cytostatic agent, after 4 courses of chemotherapy the teletherapy is used with the inclusion in the volume of irradiation primary tumour, mediastinum, roots of both lungs, cervico-supraclavicular areas from two sides. The irradiation is carried out in 2 stages: on the 1th treatment stage irradiations are carried out by ROD 2 Gy, 10 fractions, SOD 20 Gy, and on the 2th stage (in 2 weeks) - ROD 2 Gy, SOD 30 Gy. The radial therapy of cervico-supraclavicular areas is carried out by ROD 2 Gy, SOD 40 Gy, at that in the case of supraclavicular lymph nodes metastatic affect the additional irradiation of affected area is carried out by local field ROD 2 Gy, SOD 20 Gy. Polyplatilene is used as the cytostatic agent at a dose of 300 mg/m2 daily for 6 days. Then the patients take out the next 4 courses of Polyplatilene without radial therapy, an interval between courses is 4 weeks. _