anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Incompletely developed renal function in newborns may delay elimination of penicillin; therefore, appropriate reductions in the dosage and frequency of administration should be made in these patients. All newborns treated with penicillins should be monitored closely for clinical and laboratory evidence of toxic or adverse effects (see PRECAUTIONS).

Pediatric doses are generally determined on a weight basis and should be calculated for each patient individually. Recommended guidelines for pediatric dosages are presented in DOSAGE AND ADMINISTRATION.

The potential for toxic effects in children from chemicals that may leach from the single dose premixed intravenous preparation in plastic containers has not been evaluated. 

Patients should be counseled that antibacterial drugs including penicillin G potassium should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When penicillin G potassium is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may: (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by penicillin G potassium or other antibacterial drugs in the future.
The invention relates to the field of traditional Chinese medicine pharmaceutical compositions, in particular to a pharmaceutical composition and preparation for treating neck, shoulder, waist and leg diseases and a preparation method and application of the pharmaceutical composition and the preparation. The pharmaceutical composition is prepared from radix angelica sinensis, garden balsam stems, caulis spatholobi, lycopodium clavatum, pseudo-ginseng, ground beetles, amur cork tree bark, liquorice roots, fructus psoraleae, morinda officinalis, cortex acanthopanacis, mulberry twigs, the root of red-rooted salvia and gastrodia elata. The pharmaceutical composition is reasonable in component, precise in specific making and exquisite in material selection, and can achieve the purposes of diminishing inflammation, stopping pain, promoting blood circulation to remove blood stasis and supporting the healthy energy. During treatment, no injection or medicine taking or pulling or massaging or acupuncture and moxibution or operation is needed. The treatment method is simple, safety is achieved, no pain or side effect exists, cost is low, and the treatment effect is stable and lasting. The neck, shoulder, waist and leg diseases are cured fundamentally, and great pain generated after patients seek for medical advices for a long time and the diseases are not cured after long-time treatment is relieved.
BACKGROUND: Nursing literature suggested that patient mistreatment has significant impacts on nurses' emotions and job burnout. Yet, further research is needed to understand the underlying mechanism and the spillover effect on nurses' families. Leveraging the goal progress theory, this study aimed to examine the association between patient mistreatment, nurses' emotional exhaustion, and work-family conflict, as well as the mediating role of social sharing of negative work events and the moderating role of perceived organizational support.
METHODS: During the COVID-19 pandemic in China, a cross-sectional study was conducted with a sample of 1627 nurses from the Hematology Specialist Alliance of Chongqing from October to November 2022. Questionnaires were administered to measure patient mistreatment, perceived organizational support, social sharing of negative work events, emotional exhaustion, and work-family conflict. Hierarchical linear regression and conditional processes were used for statistical analyses.
RESULTS: Patient mistreatment was positively associated with emotional exhaustion (β = 0.354, p < 0.001) and work-family conflict (β = 0.314, p < 0.001). Social sharing of negative work events played a partial mediating role in the relationship between patient mistreatment and emotional exhaustion (effect = 0.067, SE = 0.013), and work-family conflict (effect = 0.077, SE = 0.014). Moderated mediation analysis found that the mediation effect was stronger when the perceived organizational support was high.
CONCLUSION: Our findings reveal the amplifying effect of social sharing of negative work events on nurses' emotional exhaustion and work-family conflict. Perceived organizational support strengthens the positive effect of patient mistreatment on the social sharing of negative work events, thus resulting in increased emotional exhaustion and work-family conflict. We also discuss practical implications, limitations, and directions for future research.
PROBLEM TO BE SOLVED: To obtain the subject composition containing the combination of a specific silicone with a cationic polymer, excellent in washability and having good cosmetic characteristics. SOLUTION: This washing composition contains components (A) and (B) in a cosmetically permissible medium. The component A comprises 4-50wt.% of a washing base comprising one or more kinds of surfactants selected from anionic, amphoteric, nonionic and cationic surfactants and their mixtures. The component B comprises a conditioning system containing the mixture of a cationic polymer. an aminated silicone and an insoluble silicone having a viscosity of <=100Pa.s (100000cSt) and different from the aminated silicone. The cationic polymer, the insoluble silicone having a viscosity of <=100Pa.s and the aminated silicone are contained in amounts of 0.001-10wt.%, 0.05-10wt.% and 0.05-10wt.%, respectively. The hair care composition can impart remarkable treatment effects, especially untangling, flexibility, smoothness, restorability and volume to rinsed hair.
PURPOSE:To obtain a useful beautifying cosmetic promoting keratin formation, quickening turn over of epidermal cells, accelerating reduction of melanin granules and increasing beautifying effects by blending a cosmetic base with a specific sphingenine. CONSTITUTION:A beautifying cosmetic base is blended with a compound shown by formula I {X is H, residue of monosaccharide, etc.; Y is H or group shown by formula II[(c)n is 19-23C aliphatic straight-chain hydrocarbon; Z is H or R<2>-CO(R<2> is 7-19C aliphatic straight chain hydrocarbon chain)]; (m) is 10-18}. The amount of the compound is preferably 0.01-2.0wt.% based on the total amount of beautifying cosmetic. When the amount of the compound blended is <0.01wt.%, the objective effect is not attained. On the other hand, the amount of the compound is >2wt.%, further improvement is the effects responding to the increase in the amount is not observed. The beautifying agent is optionally mixed with an oily component, a humectant, a surfactant, an antiseptic a perfume, etc., as the other component. 3-Hydroxy-2-(24-o- ocranoyltetracosanoylamino)-1-o-glycosyl-4-octadecene may be cited as the compound shown by formula I.
FIELD: microbiological methods. SUBSTANCE: invention provides multiphase solvent system for simultaneously cleaning and separating a variety of compound classes. These compounds can be components of cell shells or their derivatives and analogs and can be extracted from culture of relevant cells or be synthesized. Cell shell components may be microbial-origin lipids that can be separated as a group from contamination material. EFFECT: simplified diagnostics of tuberculosis. 21 cl, 30 dwg
FIELD: medicine, gynecology. SUBSTANCE: therapy is the following: beginning from the first day of starvation phytotherapy is conducted by taking into account biological hours of functional activity of the main body systems. Moreover, to influence upon gastrointestinal tract it is necessary to use water removal of medicinal plants such as camomile, sage, mint, origanum and bur marigold at 4:2:2:1:1 ratio. For an impact upon cardiovascular system valerian and leonorus roots, hawthorn fruits were used at 1:1:1 ratio. To affect urinary system one should use knot weed, St. John's wort and birch buds at 6:2:1 ratio during the first week, common horsetail, St. John's wort, calendula at 5:2:1 ratio during the second week, mountain cranberry leaf, St. John's wort, oak-tree bark at 5:2:1 ratio during the third week and black elder flowers, St. John's wort, linden flowers at 5:2:1 ratio during the fourth week. For an action upon pericardium it is useful to apply leonorus, valerian root and hawthorn fruits at 1:1:1 ratio. To have an impact upon liver and gallbladder one should take sweet flag root. EFFECT: higher efficiency of treatment including curative starvation, acupuncture and phytotherapy due to exclusion of psychotropic substances, decreased number of side effects, improved therapeutical action.
Polyunsaturated fatty acids (PUFAs) can alter adipose tissue function; however, the relative effects of plant and marine n3-PUFAs are less clear. Our objective was to directly compare the n3-PUFAs, plant-based α-linolenic acid (ALA) in flaxseed oil, and marine-based eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) in high-purity oils versus n6-PUFA containing linoleic acid (LA) for their effects on the adipose tissue and oral glucose tolerance of obese rats. Male fa/fa Zucker rats were assigned to faALA, faEPA, faDHA, and faLA groups and compared to baseline fa/fa rats (faBASE) and lean Zucker rats (lnLA). After 8 weeks, faEPA and faDHA had 11-14% lower body weight than faLA. The oral glucose tolerance and total body fat were unchanged, but faEPA had less mesenteric fat. faEPA and faDHA had fewer large adipocytes compared to faLA and faALA. EPA reduced macrophages in the adipose tissue of fa/fa rats compared to ALA and DHA, while faLA had the greatest macrophage infiltration. DHA decreased (~10-fold) T-cell infiltration compared to faBASE and faEPA, whereas faALA and faLA had an ~40% increase. The n3-PUFA diets attenuated tumour necrosis factor-α in adipose tissue compared to faBASE, while it was increased by LA in both genotypes. In conclusion, EPA and DHA target different aspects of inflammation in adipose tissue.
Premenopausal Women who are not taking hormones or birth control. Ages 35-45 who have had a negative mammograph performed at the Mayo Clinic in Rochester within the last year.
Development of peri-procedural myocardial infarction following percutaneous coronary intervention (PCI) is not uncommon and affects long-term prognosis. Clinical studies have shown that pre-treatment with atorvastatin reduced peri-procedural myocardial infarction in patients with stable angina. The mechanism of peri-procedural myocardial infarction is presumed to be microvascular embolization. However the direct causal relationship between statin pretreatment and prevention of microvascular dysfunction has not been investigated yet.

In this study, we will recruit symptomatic angina patients who have clinical indication of coronary angiography. At the time of enrollment, patients will be randomly assigned to pre-treatment group (atorvastatin 80 mg/d for 4 days) or control group. Percutaneous coronary intervention (PCI) will be perfomed based on the result of diagnostic coronary angiography by decision of attending physician. When PCI is performed, fractional flow reserve (FFR) and index of microvascular resistance (IMR) will be measured before and after the procedure. Periprocedural myocardial infarction will be defined by post-PCI cardiac biomarker. All patients will be followed for adverse cardiac events for 1 year.
Emotion dysregulation contributes to the development and maintenance of a wide range of psychopathology, but is especially relevant for individuals with bipolar mood disorders (BD). These individuals experience severe and episodic emotion dysregulation associated with maladaptive functioning, interpersonal problems, decreased work productivity, and suicidal ideation and behavior. To date, both pharmacological and psychosocial treatments fail to normalize emotion dysregulation for many bipolar patients. As a consequence, all too many experience poor outcomes. Thus, there is a significant need for new innovative approaches to target and improve emotion dysregulation in bipolar patients. Non-invasive neuromodulation using transcranial magnetic stimulation (TMS) may provide a viable strategy to help improve emotion dysregulation in bipolar mood disorders. As a first step to test this hypothesis, the current proposal seeks to experimentally identify specific neural target sites for improving emotion regulation using TMS. If the investigators can demonstrate target engagement of emotion regulation at the behavioral level using TMS, this will provide an important first step towards examining the potential utility of TMS as a viable strategy to help improve emotion dysregulation in bipolar mood disorders. While this is not a definitive clinical trial, the sham-controlled double-crossover design of this study will provide valuable information for target site selection for the development of TMS as an intervention strategy to improve emotion dysregulation in BD.
An anti-HBs monoclonal antibody is described herein. This antibody can bind to the following: (i) a wild type HBsAg; (ii) at least one mutant HBsAg selected from the group consisting of a first mutant HBsAg and a second mutant HBsAg; and (iii) at least one mutant HBsAg selected from the group consisting of a third mutant HBsAg and a fourth mutant HBsAg. The first mutant HBsAg has a mutation at position 120. The second mutant HBsAg has a mutation at position 141. The third mutant HBsAg has a substitution to a lysine at position 118. The fourth mutant HBsAg has only one mutation at position 144 and an amino acid at the position 144 is substituted by a glutamic acid.
Participants will be vaccinated with a pneumococcal vaccine on Day 1 and Day 29. Participants in this group will be aged over 60 years old.
BACKGROUND: Enucleation is a surgical technique to resect peripheral nerve schwannomas. The procedure has a low risk for postoperative deficit, but a small chance for recurrence, because tumor cells may remain inside the pseudocapsule that is left after resection. Magnetic resonance imaging (MRI) scans are frequently performed after surgery to investigate potential residual tumor, but currently there is little information in the literature on the value of follow-up with MRI.
MATERIAL AND METHODS: All patients who underwent enucleation of a peripheral nerve schwannoma between October 2013 and June 2022 were included. Postoperative MRI scans (gadolinium-enhanced) made at different time points after the surgery were re-examined for residual enhancement. Patients with residual enhancement were contacted to inform whether symptoms had recurred.
RESULTS: A total of 75 schwannoma enucleations in 74 patients were included. The first postoperative MRI scan, performed 3 months after the surgery, showed no residual enhancement in 50 patients. In the remaining 24 patients, another MRI scan was made 1 year after the surgery, which still showed a possible remnant in 11 patients. On the third MRI scan, performed 2 years after enucleation, there were 7 suspected cases (9%). None of these patients had clinical symptoms at a mean postoperative follow-up of 5 years.
CONCLUSIONS: Our data show that the value of postoperative MRI scans after enucleation of peripheral nerve schwannomas is limited, because residual enhancement in the beginning can be non-specific and the small percentage of patients, that persistently had a potential remnant, were all asymptomatic.
Certain examples provide methods, systems and apparatus of content-driven clinical information management. An example method includes facilitating authoring of content and combination of the content into a content-based application, wherein content represents a parameterization of instructions to instruct the content-based application how to operate, the content formulated according to one or more detailed clinical models. The example method includes packaging and deploying the content-based application using a processor to one or more targets for installation. The example method includes facilitating installation of the packaged content-based application at the one or more targets. The example method includes managing the content-based application remotely from the one or more targets. In the example method, content is to be created, stored, deployed, and retrieved independently of the creation and deployment of the content-based application consuming data based on the content.
BACKGROUND: Despite modern antiretroviral therapy (ART), people living with HIV (PLWH) have increased relative risk of inflammatory-driven comorbidities, including cardiovascular disease (CVD). The gut microbiome could be one of several driving factors, along with traditional risk factors and HIV-related risk factors such as coinfections, ART toxicity, and past immunodeficiency.
RESULTS: PLWH have an altered gut microbiome, even after adjustment for known confounding factors including sexual preference. The HIV-related microbiome has been associated with cardiometabolic comorbidities, and shares features with CVD-related microbiota profiles, in particular reduced capacity for short-chain fatty acid (SCFA) generation. Substantial inter-individual variation has so far been an obstacle for applying microbiota profiles for risk stratification. This review covers updated knowledge and recent advances in our understanding of the gut microbiome and comorbidities in PLWH, with specific focus on cardiometabolic comorbidities and inflammation. It covers a comprehensive overview of HIV-related and comorbidity-related dysbiosis, microbial translocation, and microbiota-derived metabolites. It also contains recent data from studies in PLWH on circulating metabolites related to comorbidities and underlying gut microbiota alterations, including circulating levels of the SCFA propionate, the histidine-analogue imidazole propionate, and the protective metabolite indole-3-propionic acid.
CONCLUSIONS: Despite recent advances, the gut microbiome and related metabolites are not yet established as biomarkers or therapeutic targets. The review gives directions for future research needed to advance the field into clinical practice, including promises and pitfalls for precision medicine. Video Abstract.
Current evidence shows an inter-country inconsistency in the effect of lesion size on the technical difficulty of gastric endoscopic submucosal dissection (ESD). We aimed to evaluate the specific correlation and quantify the ensuing risks. This retrospective study consisted of 405 ESD cases with gastric single lesion from April 2015 to April 2023. The correlation and risk prediction of lesion size with technical difficulty was explored to provide further clinical evidence. An additive generalized model and recursive algorithm were used to describe the non-linear association, and a linear two-piece regression was constructed to analyze the inflection point. Subgroup analysis and interaction were used to explore intergroup characteristics. Overall, difficult cases had larger lesion sizes, and the more significant the increase, the higher the risk of technical difficulty. In the full model, after adjusting for all covariates, each 1 mm, 3 mm, 5 mm, 7 mm, and one standard increase in lesion size increased the risk of technical difficulty by 8%, 26%, 42%, 72%, and 125%, respectively. There is a nonlinear positive correlation between lesion size and risk of technical difficulty, and the premeditated inflection point was 40 (mm) via two-piecewise linear regression and recursive algorithm. Subgroup analysis showed a stronger correlation between lesion size and difficult ESD in the upper site and submucosal fibrosis groups. Available evidence suggests that lesion size as a risk signal nonlinearly increases the technical difficulty of gastric ESD procedure, especially in cases of upper site and submucosal fibrosis, which deserves further investigation.
Postoperative peritoneal adhesions are a prevalent clinical issue following abdominal and pelvic surgery, frequently resulting in heightened personal and societal health burdens. Traditional biomedical barriers offer limited benefits because of practical challenges for doctors and their incompatibility with laparoscopic surgery. Hydrogel materials, represented by hyaluronic acid gels, are receiving increasing attention. However, existing antiadhesive gels still have limited effectiveness or carry the risk of complications in clinical applications. Herein, we developed a novel hydrogel using polysaccharide hemoadhican (HD) as the base material and polyethylene glycol diglycidyl ether (PEGDE) as the cross-linking agent. The HD hydrogels exhibit appropriate mechanical properties, injectability, and excellent cytocompatibility. We demonstrate resistance to protein adsorption and L929 fibroblast cell adhesion to the HD hydrogel. The biodegradability and efficacy against peritoneal adhesion are further evaluated in C57BL/6 mice. Our results suggest a potential strategy for anti-postoperative tissue adhesion barrier biomaterials.
PURPOSE: A skin whitening composition having an extract of Oenanthe javanica(BL)DC. is provided. It reduces melanin formation by inhibiting the proliferation of melanin cells and tyrosinase activity participating in melanin formation while simultaneously containing skin whitening effect. It also has extended storage. CONSTITUTION: A skin whitening composition contains 0.01 to 10% by weight of an extract of Oenanthe javanica(BL)DC. The extract is one or more selected from the group consisting of a freeze dried extract, a hot water extract and an ethanol extract of Oenanthe javanica(BL)DC. The freeze dried extract is obtained by grinding Oenanthe javanica(BL)DC. in a mixer or homogenizer, freezing in a deep freezer over night and then drying in a freeze dryer for 2 to 3 days. The extract exhibits inhibition effect on tyrosinase.
The invention is related to methods, systems, client computing devices, and server computing devices for enhancing the efficiency of the use of digital equipment by changing habits of a user of a client computing device. The invention encompasses: monitoring, for a first monitoring time period, the behavior of the user interacting with a client user interface of the client computing device and collecting first user behavior data. Transmitting, with a client transceiver of the client computing device, the first user behavior data to a server transceiver of a server computing device. Receiving, with the server transceiver, the first user behavior data. Storing, in a server memory of the server computing device, the first user behavior data. Determining a user habit, based on the first user behavior data. Selecting, by the server computing device, a first user habit change stimulus from a plurality of user habit change stimuli, based on the user habit, the first user behavior data and the behavior data of other users stored in the server memory. Transmitting, with the server transceiver, the first habit change stimulus to the client transceiver. Receiving, with the client transceiver, the first user habit change stimulus. Applying, via the client user interface, the first user habit change stimulus to the user. Monitoring, for a second monitoring time period, the behavior of the user interacting with the client user interface and collecting second user behavior data. Determining whether the user has changed the first user habit. And, finally, if the user has changed the first user habit in the desired direction and if there are further user habits to be changed, concentrating on a further user habit.
For all Phase B participants randomized to the active CC group, BLT will occur each morning after awakening and will last for 30 minutes and BLB at night from 8:00 pm until going to sleep throughout the 4-week intervention period. Participants in the CC group will also receive a sleep hygiene education.