anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients undergo collection of fecal specimens at baseline, prior to start of each course of chemotherapy or immunotherapy, at the end of weeks 2, 4, 6, and 8, at the end of course 3 and courses thereafter of chemotherapy or immunotherapy, and at the time of disease progression or going off-treatment. Fecal specimens are analyzed via 16S ribosomal RNA gene sequencing, meta-transcriptomics analysis, and meta-proteomics analysis.
<P>PROBLEM TO BE SOLVED: To obtain a natural cosmetic improving the bleaching effect of a naturally derived cosmetic along with yielding the effect of preventing or ameliorating rough skin.  <P>SOLUTION: The natural cosmetic is obtained by the following procedure: The whole grass of the leaves, stems and roots of Houttuynia cordata is finely chopped and washed with water and then soaked in 70 mL of rice Shochu(Japanese white distilled liquor) 20% in alcohol concentration at room temperature in a dark place for one month. The solids are then filtered off to obtain an alcohol extract liquid of Houttuynia cordata. Whereas, 100 g of dried white mulberry root bark is soaked in 400 mL of an aqueous alcohol solution that is prepared from 300 mL of anhydrous ethanol and 100 mL of purified water, left at rest at room temperature in a dark place for one week. The solids are then filtered off to obtain an alcohol extract liquid of white mulberry root bark. The objective cosmetic, a bleaching skin lotion, is obtained by adding 1.4 mL of the alcohol extract liquid of white mulberry root bark to 100 mL of the alcohol extract liquid of Houttuynia cordata. This skin lotion has bleaching effect about 1.5-2 times that of Houttuynia cordata and white mulberry root bark each, having the effects of preventing and ameliorating rough skin as well.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The study includes 2 weeks of monitoring of the participants' patterns of sleep and wakefulness at home. At the beginning of this period, all participants will undergo measurements of their body composition (lean tissue, bone and fat) and their metabolic rate at rest and after a standard meal. At that time, all participants will also drink a glass of water containing harmless non-radioactive dense forms of oxygen and hydrogen, small amounts of which are found in natural water. Several urine samples will be collected before and after the participants drink the water at the beginning of the study and again 14 days later in order to measure the amount of energy that was used by them during this time. Participants will also wear small wristwatch-like activity monitors on their wrist and around their waist as they follow their usual everyday activities and sleep-wake schedules at home. The recordings from these monitors combined with daily sleep logs will be used to determine when the participants slept and when they were awake. On the last day of the study, the participants will undergo MRI measurements of the distribution of fat in their abdomen and complete a graded exercise test on a treadmill or stationary bicycle in order to determine what is the most strenuous level of exercise that they can perform. A medical doctor will supervise all study procedures that are done in the research laboratory.
Techniques disclosed herein relate to monitoring changes in conditions of multiple individuals in areas. In some embodiments, a patient monitoring queue may be established (504) that includes a plurality of patients in an area (104, 304) such as a waiting room. The area may be capturable by vital sign acquisition camera(s) (276. 376, 476) mounted in or near the area. Updated vital sign(s) may be unobtrusively acquired (510) by the vital sign acquisition camera(s) from a given patient selected (506) from the patient monitoring queue. Based on the updated vital sign(s) and prior vital signs acquired previously from the given patient, deterioration of the given patient may be detected (512). Output may be provided (514) alerting medical personnel of the deterioration of the given patient.
A service uses internet, intranet or other network based deployment and technologies to encourage and facilitate customers  12  in losing weight or achieving some other desired goal. The weigh-in service uses a novel online scheduler  24  and tracks customer weigh-ins, graphical and pictorial tracking of these weigh-ins, online food and nutritional information, reinforcing emails, and a consultant who “cheerleads” her/his customer to successful weight loss. Customers who seek additional motivation will be able to use a wifi scale at weigh-ins to keep them on track. The overall program is aimed at providing quick bursts of support, referred to as “cheerleading” for a customer on any type of diet, and/or exercise regimen or other goal based program. The consultant will refocus the customer to keep the customer on their program. The online chat scheduler operates in connection with or autonomously from the weigh-in service and allows the consultants and users (or first parties and second parties) to schedule and pre-pay for appropriate times during which online chat will be available to the customer or first party and not available or viewable at any other time.
Kenalog is a topical corticosteroid that shares anti-inflammatory, anti-pruritic, and vasoconstrictive actions.The dosage of Kenalog used in the study is 0.5%. Application is topical, and the frequency is 3 times a day for the 3 week trial period. FDA approved use of Kenalog in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It has not been studied whether Kenalog has any proven advantage over Silver nitrate in the treatment of granulation tissue, but it has been used for the treatment of granulation tissue at the gastrostomy site with good effect.
In recent years, air pollution has garnered global attention due to its ability to traverse borders and regions, thereby impacting areas far removed from the emission sources. While prior studies predominantly focused on the deleterious effects of PM2.5 on the respiratory and cardiovascular systems, emerging evidence has highlighted the potential risks of PM2.5 exposure to the central nervous system. Nonetheless, research elucidating the potential influences of PM2.5 exposure on seizures, specifically in relation to neuronal ferroptosis, remains limited. In this study, we investigated the potential effects of PM2.5 exposure on seizure symptoms and seizures-induced hippocampal neuronal ferroptosis. Our findings suggest that seizure patients residing in regions with high PM2.5 levels are more likely to disturb iron homeostasis and the Nrf2 dependent ferroptosis pathway compared to those living in areas with lower PM2.5 levels. The Morris Water Maze test, Racine scores, and EEG recordings in epileptic mice suggest that PM2.5 exposure can exacerbate seizure symptoms and cognitive dysfunction. Neurotoxic effects of PM2.5 exposure were demonstrated via Nissl staining and CCK-8 assays. Direct evidence of PM2.5-induced hippocampal neuronal ferroptosis was provided through TEM images. Additionally, increased Fe2+ and lipid ROS levels indirectly supported the notion of PM2.5-induced hippocampal ferroptosis. Therefore, our study underscores the necessity of preventing and controlling PM2.5 levels, particularly for patients with seizures.
OBJECTIVE: This review will determine whether various health interventions designed to reduce weight (lifestyle change, bariatric surgery, pharmacotherapy) in men with obesity are associated with improved fertility markers. The review will also establish whether the degree of weight loss achieved through these methods is associated with improvement.
INTRODUCTION: Current preconception guidelines provide limited information for men with obesity. Small studies implementing lifestyle changes in men are associated with improvement in sperm quality, whereas bariatric surgery has not been associated with improvements in sperm quality. Determining the benefit of different interventions and the relationship to weight lost is necessary to optimize male fertility.
INCLUSION CRITERIA: The population will be men younger than 50 years with overweight (BMI >25 kg/m 2 ) or obesity (BMI >30 kg/m 2 ). The exposure of interest will be an intervention undertaken to improve health or reduce weight, categorized as lifestyle change, bariatric surgery, or pharmacotherapy. Outcomes will include time to conception, fecundity rate, assisted reproduction outcomes, and semen quality measures. Secondary analysis will determine whether degree of weight loss achieved is associated with degree of improvement.
METHODS: This review will follow the JBI methodology for systematic reviews of etiology and risk. Databases to be searched will include PubMed, Embase (Ovid), Cochrane Central Register of Controlled Trials, Web of Science Core Collection, and Scopus. Articles not published or translated into English will be excluded. Methodological quality will be assessed using the JBI critical appraisal tools. Data will be extracted using a tool developed by the reviewers. Statistical meta-analysis will be performed where possible to synthesize outcomes of similar methods.
REVIEW REGISTRATION: PROSPERO CRD42022349665.
An adapted version of the Relaxation Response Resiliency Program (3RP) for siblings of children with ASD. The adapted program incorporates the three prongs of the 3RP: RR elicitation, stress awareness, and adaptive strategies.
BACKGROUND: Bisphenol A (BPA) is an environmental contaminant with endocrine-disrupting properties that induce fetal growth restriction (FGR). Previous studies on pregnant ewes revealed that BPA exposure causes placental apoptosis and oxidative stress (OS) and decreases placental efficiency, consequently leading to FGR. Nonetheless, the response of gut microbiota to BPA exposure and its role in aggravating BPA-mediated apoptosis, autophagy, mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and OS of the maternal placenta and intestine are unclear in an ovine model of gestation.
RESULTS: Two pregnant ewe groups (n = 8/group) were given either a subcutaneous (sc) injection of corn oil (CON group) or BPA (5 mg/kg/day) dissolved in corn oil (BPA group) once daily, from day 40 to day 110 of gestation. The maternal colonic digesta and the ileum and placental tissue samples were collected to measure the biomarkers of autophagy, apoptosis, mitochondrial dysfunction, ERS, and OS. To investigate the link between gut microbiota and the BPA-induced FGR in pregnant ewes, gut microbiota transplantation (GMT) was conducted in two pregnant mice groups (n = 10/group) from day 0 to day 18 of gestation after removing their intestinal microbiota by antibiotics. The results indicated that BPA aggravates apoptosis, ERS and autophagy, mitochondrial function injury of the placenta and ileum, and gut microbiota dysbiosis in pregnant ewes. GMT indicated that BPA-induced ERS, autophagy, and apoptosis in the ileum and placenta are attributed to gut microbiota dysbiosis resulting from BPA exposure.
CONCLUSIONS: Our findings indicate the underlying role of gut microbiota dysbiosis and gut-placental axis behind the BPA-mediated maternal intestinal and placental apoptosis, OS, and FGR. The findings further provide novel insights into modulating the balance of gut microbiota through medication or probiotics, functioning via the gut-placental axis, to alleviate gut-derived placental impairment or FGR. Video Abstract.
The invention discloses attapulgite/wild chrysanthemum/green tea toothpaste and a production method thereof. The technical proposal is that: the production method comprises the following steps: steaming for enzyme deactivation, preparing ingredients, low-speed stirring, pulverization and pulping, milling, high-speed stirring, vacuum degassing and packaging. Through the steps, finished products of attapulgite/wild chrysanthemum/green tea toothpaste are obtained. The attapulgite/wild chrysanthemum/green tea toothpaste contains pasty attapulgite clay, fresh green tea, fresh honeysuckle flower, fresh peppermint, fresh lalang grass rhizome, sodium dodecylsulfate, potassium sorbate and deionized water. Plant fibers produced by pulverization and milling can not only increase the viscosity of the toothpaste but also improve the abrasion effect and stability of the toothpaste. The attapulgite/wild chrysanthemum/green tea toothpaste has soft and fine texture and oral cleaning and refreshing functions, and can adsorb and eliminate odors in oral cavity. The inventive method is suitable for the production of attapulgite/wild chrysanthemum/green tea toothpaste, herbal toothpaste and other medicinal toothpaste.
As with any NSAID, caution should be exercised in treating the elderly (65 years and older) and when increasing the dose (see Error! Hyperlink reference not valid.).

In etodolac clinical studies, no overall differences in safety or effectiveness were observed between these patients and younger patients. In pharmacokinetic studies, age was shown not to have any effect on etodolac half-life or protein binding, and there was no change in expected drug accumulation. Therefore, no dosage adjustment is generally necessary in the elderly on the basis of pharmacokinetics (see CLINICAL PHARMACOLOGY, Special Populations).

Elderly patients may be more sensitive to the antiprostaglandin effects of NSAIDs (on the gastrointestinal tract and kidneys) than younger patients (see Error! Hyperlink reference not valid.). In particular, elderly or debilitated patients who receive NSAID therapy seem to tolerate gastrointestinal ulceration or bleeding less well than other individuals, and most spontaneous reports of fatal GI events are in this population. Etodolac is eliminated primarily by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see Error! Hyperlink reference not valid.).
Individuals in the this group will be given 24 hours of yoga training 3 times a week for 8 weeks. During the training, individuals will be asked to wear compression stockings during the 8 weeks. An educational booklet will be given to the each group.
Products for oxidative dyeing of keratin fibres include at least two preparations (A) and (B) prepared separately. The first preparation (A) includes, in a cosmetic carrier (A1) hydrogen peroxide and (A2) one or more fatty constituents in an amount of from about 0.1 to about 40 wt. % relative to the weight of preparation (A). The second preparation (B) includes, in a cosmetic carrier, (B1) at least one alkalizing agent and (B2) one or more fatty constituents in an amount of from about 0.1 to about 40 wt. % relative to the weight of preparation (B). Preparation (A) is prepared in a first container and preparation (B) is prepared in a second container, both of which containers include at least two layers. An inner layer of first and/or second containers includes a layer of a synthetic polymer (I). An outer layer of first and/or second containers includes a layer of metal.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, immune-mediated disorder in which an aberrant immune response causes demyelination and axonal damage of the peripheral nerves. Genetic contribution to CIDP is unclear and no genome-wide association study (GWAS) has been reported so far. In this study, we aimed to identify CIDP-related risk loci, genes, and pathways. We first focused on CIDP, and 516 CIDP cases and 403,545 controls were included in the GWAS analysis. We also investigated genetic risk for inflammatory polyneuropathy (IP), in which we performed a GWAS study using FinnGen data and combined the results with GWAS from the UK Biobank using a fixed-effect meta-analysis. A total of 1,261 IP cases and 823,730 controls were included in the analysis. Stratified analyses by gender were performed. Mendelian randomization (MR), colocalization, and transcriptome-wide association study (TWAS) analyses were performed to identify associated genes. Gene-set analyses were conducted to identify associated pathways. We identified one genome-wide significant locus at 20q13.33 for CIDP risk among women, the top variant located at the intron region of gene CDH4. Sex-combined MR, colocalization, and TWAS analyses identified three candidate pathogenic genes for CIDP and five genes for IP. MAGMA gene-set analyses identified a total of 18 pathways related to IP or CIDP. Sex-stratified analyses identified three genes for IP among males and two genes for IP among females. Our study identified suggestive risk genes and pathways for CIDP and IP. Functional analyses should be conducted to further confirm these associations.
AIMS: Digital noise reduction (DNR) minimizes the effect of noise on speech signals by continuously monitoring frequency bands in the presence of noise. In the present study, we explored the effect of DNR technology on speech intelligibility in individuals using hearing aids (HAs) and investigated implications for daily use.
METHODS AND MATERIAL: Eighteen participants with bilateral moderate sensorineural hearing loss (aged 16-45 years) were included. Bilateral receiver-in-the-ear HAs were fitted in the participants. The adaptive and nonadaptive (with a signal-to-noise ratio (SNR) of +5 and -5 dB, respectively) Turkish matrix sentence test (TURMatrix) in noise and free-field hearing assessments, including hearing thresholds with hearing aids, speech recognition thresholds (SRT), and speech discrimination scores, were conducted in two different conditions: HA in the DNR-on and DNR-off conditions.
RESULTS: No significant difference was observed between free-field hearing assessments with the HA in the DNR-off and DNR-on conditions (P > 0.05). Furthermore, the adaptive and nonadaptive TURMatrix revealed significant differences between the scores under the DNR-on and DNR-off conditions (P < 0.05). Nevertheless, under the DNR-on condition, there was no correlation between free-field hearing assessments with HA and TURMatrix results (P > 0.05). However, a significant correlation was observed between SRT scores with HA and TURMatrix scores (adaptive and nonadaptive, +5 and -5 dB SNR, respectively) under the DNR-off condition (P < 0.05).
CONCLUSION: Our study findings suggest that DNR can improve speech intelligibility in noisy environments. Therefore, DNR can enhance an individual's auditory comfort by improving their capacity to grasp speech in background noise.
The invention belongs to the technical fields of biological medicine and molecular biology, and particularly relates to imiquimod prodrug nanoparticles, and a preparation method and application thereof. The invention uses chemical means to mask the C4 amino of imiquimod to obtain IMQ prodrug, the prodrug has GSH sensitivity, at the same time adopts RAFT polymerization technology to polymerize synthetic monomer, and makes modification of tumor targeting peptide on polymer, finally obtains nano-level nanoparticle delivery system by self-assembly technology. After intravenous injection, the nanosystems are relatively stable and will not be released in advance due to the lack of GSH environment. The nanosystems aggregate into tumor tissue through targeting of tumor targeting peptides. After endocytosis of the tumor cells, high GSH levels within the tumor cells promote disintegration of the nanosystems, and then release free IMQ. The free IMQ enhances infiltration of T lymphocytes in the tumor microenvironment by activating dendritic cells, which is beneficial for safe and effective delivery of IMQ.
Human pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study analyzed ten human embryonic stem cell lines across multiple passages to elucidate the dynamics of chromosomal abnormalities and single-nucleotide variants (SNVs) in 380 cancer-related genes. Prolonged in vitro culture resulted in 80% of the lines acquiring gains of chromosome 20q or 1q, both known for conferring an in vitro growth advantage. 70% of lines also acquired other copy number variants (CNVs) outside the recurrent set. Additionally, we detected 122 SNVs in 88 genes, with all lines acquiring at least one de novo SNV during culture. Our findings showed higher loads of both CNVs and SNVs at later passages, which were due to the cumulative acquisition of mutations over a longer time in culture, and not to an increased rate of mutagenesis over time. Importantly, we observed that SNVs and rare CNVs followed the acquisition of chromosomal gains in 1q and 20q, while most of the low-passage and genetically balanced samples were devoid of cancer-associated mutations. This suggests that recurrent chromosomal abnormalities are potential drivers for the acquisition of other mutations.
Interactive Learning for Smokers (ILS) is a 7-week intervention that provides a closely matched active control group for MTS, but with substantive education and skills training for smoking cessation. To this end, ILS combines elements of two smoking cessation programs, the American Lung Association, Freedom from Smoking program and The Mayo Clinic Nicotine Dependence Center program. ILS participants were asked to practice 30 minutes of silent non-directed walking per day throughout the intervention and were instructed to use non-directed walking for relaxation, stress reduction and as a strategy for managing urges and withdrawal symptoms.
Endoscopic ultrasound (EUS)-guided tissue acquisition has emerged as a valuable method to diagnose autoimmune pancreatitis (AIP) and exclude malignancy. During Endoscopic Ultrasound (EUS), tissue samples can be obtained for pathological evaluation with different devices. Previous studies suggest 19-gauge fine needle aspiration (FNA) needle provides a reliable specimen for diagnosis of AIP. However tissue architecture and cell morphology are essential for accurate pathological assessment. Therefore, pathologists generally prefer a histological specimen. Fine needle biopsy (FNB) has the advantage of obtaining a histological specimen, which may lead to better diagnostic performance. However, the superiority of histology over cytology in EUS-guided tissue sampling for diagnosis of AIP has not been proven yet. In this study, we aim to compare the diagnostic accuracy of two EUS-guided tissue acquisition devices; the 19G Echotip Ultra Fine Needle Aspiration (FNA) device and the 20G Echotip ProCore Fine Needle Biopsy (FNB) device for the diagnosis of autoimmune pancreatitis.
A composition is claimed that comprises, as an effective ingredient, a polyether of MW >400 having Ci-C3o branched units and C1-C24 linear units. The copolymer, which is typically a pluronic or synperonic, is thought to act as an inhibitor of the enzyme lipase so that the composition is of therapeutic use in the treatment of a variety of conditions including dandruff, acne, obesity and body odour. An additional, preferred use is against lipases derived from micro-organisms (ie. against skin rash). In one embodiment the polymer is impregnated into an absorbent article, preferably a bandage. The composition is further claimed for use in the preservation of food or beverage products.
Participants will receive epoetin beta at an initial dose of 30,000 International Units (IU) per week administered subcutaneously (SC). Response will be firstly evaluated at Week 4 and the subsequent dose will be based on the response: if hemoglobin level reaches greater than or equal to (\>/=)12 grams per deciliter (g/dL) at any time, epoetin beta will be discontinued until hemoglobin levels are less than or equal to (\</=) 10 g/dL; if the hemoglobin level increases less than (\<) 1 g/dL from screening level and hemoglobin level ˂12 g/dL, a 60,000 IU per week epoetin beta will be administered SC until Week 12; if the hemoglobin level increases \>/=1 g/dL from screening level and hemoglobin level ˂12 g/dL, a 30,000 IU per week epoetin beta will be continued until Week 12.