anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A kidney cancer therapeutic composite and cosmetic composition with extract from Aurantii Immatri Pericarpium is provided to expect the treatment effect making ACHN cells to die by inserting the extract from CITRY PERICAfrum to the ACHN kidney cells. CONSTITUTION: A kidney cancer therapeutic composite and a cosmetic composition in lucdx extract from Aurantii Immatri Pericarpium ethanol as an active material. The ethanol extract is extracted in 50 degree C for 24 hours. The ethanol extract is dried and condensed in 45 degree C under decreased pressure condition. The ethanol includes a carrier which is pharmaceutically acceptable or a diluting agent. A kidney cancer is a kidney cell cancer. [Reference numerals] (AA) Relative cellular viability
INTRODUCTION: The cervical flexion-relaxation ratio (FRR) is known as a quantitative measure of the ability of the cervical extensor muscles to relax during the full flexion of the cervical spine. Compared with subjects suffering from non-specific neck pain, the changes occurring in the pattern of the neck muscles' functions in cases with cervical spinal stenosis are not yet well understood. Therefore, this study aimed to compare cervical FRR in subjects with cervical lateral spinal stenosis and asymptomatic controls.
METHODS: In total, 25 subjects with cervical lateral spinal stenosis (aged 44.7 ± 10.4) and 25 asymptomatic individuals (aged 44.3 ± 10.8) were included in this study. These participants performed full-neck flexion, and at the same time, the electrical activity of the cervical erector spinae (CES) muscles was recorded bilaterally. Cervical FRR was further calculated by analyzing the electromyographic data recorded for each muscle.
RESULTS: The mean cervical FRR was significantly lower (P = 0.015) and the FRR asymmetry (ΔFRR) was significantly higher (P = 0.003) in the patients than asymptomatic controls. In addition, the cervical FRR of the involved side was significantly lower in the subjects with cervical pain compared with that in the non-involved one (P = 0.004). There was also a significant difference in the cervical extension (CE) angle between both study groups (P < 0.001), while the cervical flexion (CF) angle was not different (P = 0.25).
CONCLUSION: According to the study results, FRR and its asymmetry in the subjects with cervical lateral spinal stenosis were significantly different from that in asymptomatic controls and the CE angle declined in these subjects.
Patients undergo collection of blood or mouthwash samples. Patients undergo genotyping with enhanced risk assessment on study. 4 to 8 weeks later, patients receive a follow-up phone call for return of enhanced risk assessment results and tailored counseling.
The present invention relates to an X-ray colon special double-comparison contrast agent, particularly to a medical X-ray contrast agent. The contrast agent is composed of 15 to 25 parts by weight of barium sulfate, 0.012 to 0.048 part by weight of citric acid osmium potassium, and a right amount of silicone. The concentration of the contrast agent is 125% (W/V). The contrast agent is used for barium enema once; a result visible outline displays obvious density, and has good consistency, and the outline of right hemicolon is clear. Compared with the existing barium contrast agent, the display rate of sulcus anonymus of the present invention is improved. After barium gas is discharged, rechecking is carried out, and the rugal of colonic mucosa is clearly displayed. The X-ray colon special double-comparison contrast agent is favorable for the differential diagnosis of the early diagnosis of X-rays of colon diseases.
Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe cardiovascular events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection and timely intervention of plaques are challenging due to the lack of typical symptoms in the initial stages. Therefore, precise early detection and intervention play a crucial role in risk stratification of atherosclerotic plaques and achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, and specific targeting capabilities for imaging agents and therapeutic drugs, enabling effective visualization and management of atherosclerotic plaques. Motivated by these superior properties, various noninvasive imaging modalities for early recognition of plaques in the preliminary stage of atherosclerosis are comprehensively summarized. Additionally, several therapeutic strategies are proposed to enhance the efficacy of treating atherosclerotic plaques. Finally, existing challenges and promising prospects for accelerating clinical translation of nanoplatform-based molecular imaging and therapy for atherosclerotic plaques are discussed. In conclusion, this review provides an insightful perspective on the diagnosis and therapy of atherosclerotic plaques.
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer in Asia including Taiwan, with distinct epidemiological, clinical, and pathological features from esophageal adenocarcinoma which is commonly seen in Western countries. For decades, esophageal cancer has ranked as one of top leading causes of cancer-related death in Taiwan. Most ESCC patients are men, and present with locally advanced or metastatic disease at diagnosis. Chemoradiotherapy and surgery are commonly employed in patients with locally advanced ESCC; however, more than half of them would eventually develop disease recurrence or distant metastasis. Chemotherapy is the mainstay of treatment for patients with recurrent and metastatic ESCC; unfortunately, the efficacy of chemotherapy has been limited and unsatisfactory. Even anti-program cell death protein 1 (PD-1)- based immunotherapy has recently become an important treatment modality for advanced ESCC, the prognosis of these patients remains poor with a median survival time around a year. Therefore, a better understanding of this deadly disease is crucial for finding better therapeutic strategies for these patients.

A trend of increasing incidence in young age (less than 45-years-old) has been observed in Taiwan recently. This disease not only could devastate these young patients but also would cause huge financial impact to their families. In one of our previous study focusing on the prognosis of metastatic or recurrent ESCC patients treated with systemic chemotherapy, the investigators found that elderly ESCC patients might have better prognosis than young patients. Additionally, the preliminary data of our recent works suggest that the genetic alterations of ESCC in patients of different age groups might be distinct. However, whether the genetic alterations are significantly different among ESCC patients of different age groups and whether the differences exhibit any prognostic or predictive impact have not yet been systematically investigated.

The investigators thus proposed this multi-center research project to address the fore-mentioned questions by collecting tumor tissues from ESCC patients for next-generation sequencing analysis with a panel of cancer-related genes, and creating a platform for data storage and sharing. The specific aims of this project are (1) to establish the tumor genetic and molecular profiles of ESCC in Taiwan, (2) to compare the difference of the genetic and molecular profiles among different age groups of ESCC patients, and (3) to reveal the evolution changes of genetic and molecular profiles of ESCC. The long-term goals of this study are to help implement personalized therapy, to develop novel therapy, and to improve outcomes of patients with ESCC.
Ortho-substituted benzoylguanidines a process for their preparation, their use as a medicament or diagnostic agent and a medicament comprising them.           Benzoylguanidines of the formula I     (see fig. I) in which: R(1) to R(4) have the meanings given in the claims, are antiarrhythmicpharmaceuticals having a cardioprotective component, which are also valuable forthe prevention of ischemically induced damage in particular in association with the triggering of ischemically induced cardiac arrhythmias. As a consequence of inhibiting the cellular Na+/H+ exchange mechanism they are used for treating acute or chronic damage triggered by ischemia. In addition to this they are notable for their strong inhibitory effect on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.
BACKGROUND: Patients in burns centres are at high risk of acquiring multi-drug-resistant organisms (MDROs) due to the reduced skin barrier and long hospital stay.
METHODS: This study reports the investigation and control of an outbreak of MDR Acinetobacter baumannii in a burns centre. The 27 patients hospitalized in the centre during the outbreak were screened regularly, and a total of 132 environmental samples were analysed to identify a potential source. Fourier-transform infra-red (FT-IR) spectroscopy and multi-locus sequence typing were applied to characterize the outbreak strain.
RESULTS: Between August and November 2022, the outbreak affected eight patients, with 11 infections and three potentially related fatal outcomes. An interdisciplinary and multi-professional outbreak team implemented a bundle strategy with repetitive admission stops, isolation precaution measures, patient screenings, enhanced cleaning and disinfection, and staff education. FT-IR spectroscopy suggested that the outbreak started from a patient who had been repatriated 1 month previously from a country with high prevalence of MDR A. baumannii. Environmental sampling did not identify a common source. Acquisition of the outbreak strain was associated with a higher percentage of body surface area with burn lesions ≥2a [per percent increase: odds ratio (OR) 1.05, 95% confidence interval (CI) 0.99-1.12; P=0.09], and inversely associated with a higher nurse-to-patient ratio (per 0.1 increase: OR 0.34, 95% CI 0.10-1.12; P=0.06).
CONCLUSIONS: Burn patients with a higher percentage of body surface area with burn lesions ≥2a are at high risk of colonization and infection due to MDROs, particularly during periods of high workload. A multi-faceted containment strategy can successfully control outbreaks due to MDR A. baumannii in a burns centre.
PURPOSE OF REVIEW: This review examines recent research on artificial intelligence focusing on machine learning (ML) models for predicting postoperative pain outcomes. We also identify technical, ethical, and practical hurdles that demand continued investigation and research.
RECENT FINDINGS: Current ML models leverage diverse datasets, algorithmic techniques, and validation methods to identify predictive biomarkers, risk factors, and phenotypic signatures associated with increased acute and chronic postoperative pain and persistent opioid use. ML models demonstrate satisfactory performance to predict pain outcomes and their prognostic trajectories, identify modifiable risk factors and at-risk patients who benefit from targeted pain management strategies, and show promise in pain prevention applications. However, further evidence is needed to evaluate the reliability, generalizability, effectiveness, and safety of ML-driven approaches before their integration into perioperative pain management practices.
SUMMARY: Artificial intelligence (AI) has the potential to enhance perioperative pain management by providing more accurate predictive models and personalized interventions. By leveraging ML algorithms, clinicians can better identify at-risk patients and tailor treatment strategies accordingly. However, successful implementation needs to address challenges in data quality, algorithmic complexity, and ethical and practical considerations. Future research should focus on validating AI-driven interventions in clinical practice and fostering interdisciplinary collaboration to advance perioperative care.
INTRODUCTION: Collagen triple helix repeat containing 1 (CTHRC1) is a protein that has been implicated in pro-migratory pathways, arterial tissue-repair processes, and inhibition of collagen deposition via the regulation of multiple signaling cascades. Studies have also demonstrated an upregulation of CTHRC1 in multiple cancers where it has been linked to enhanced proliferation, invasion, and metastasis. However, the understanding of the exact role and mechanisms of CTHRC1 in cancer is far from complete.
AREAS COVERED: This review focuses on analyzing the role of CTHRC1 in cancer as well as its associations with clinicopathologies and cancer-related processes and signaling. We have also summarized the available literature information regarding the role of CTHRC1 in tumor microenvironment and immune signaling. Finally, we have discussed the mechanisms associated with CTHRC1 regulations, and opportunities and challenges regarding the development of CTHRC1 as a potential target for cancer management.
EXPERT OPINION: CTHRC1 is a multifaceted protein with critical roles in cancer progression and other pathological conditions. Its association with lower overall survival in various cancers, and impact on the tumor immune microenvironment make it an intriguing target for further research and potential therapeutic interventions in cancer.
INTRODUCTION: The prostatic utricle (PU) consists of the caudal remnant of the Müllerian duct and the urogenital sinus. The term "vagina masculina" is used if other Müllerian structures are associated with the PU. This work aims to investigate the incidence, management, and follow up of enlarged PUs and Müllerian remnants in males with posterior hypospadias.
PATIENTS AND METHODS: This study presents a retrospective review of cases presented with posterior hypospadias over a 5-year period. Prior to hypospadias repair, retrograde urethrograms were used to investigate enlarged PU. Subsequently, they were classified according to the Ikoma score and further assessed by karyotyping and cystoscope. Surgical excision was indicated in cases with symptomatic utricles or vagina masculina.
RESULTS: Thirty patients were included in the study in the period between 2015 and 2020 (Table). All cases were asymptomatic initially. Twelve patients were diagnosed with enlarged PU; three of them had vagina masculina. One case with perineal hypospadias had a separate perineal opening for PU. Following hypospadias repair, three of the eight cases treated conservatively turned symptomatic.
DISCUSSION: The incidence of enlarged PU and Müllerian remnants varied among different studies. However, it increased as the severity of hypospadias increased. Preoperative urethrogram was helpful in the diagnosis and classification of PU, but it had its limitations. Cystoscope was more advantageous in diagnosing vagina masculina. Although most cases were asymptomatic, some turned symptomatic after hypospadias repair. Some cases with perineal hypospadias had PU with a separate perineal opening.
CONCLUSION: The incidence of enlarged PUs or Müllerian remnants was 40%. Although cases were asymptomatic before hypospadias surgery, some cases turned into symptomatic after hypospadias repair. In some cases, the PU or Müllerian remnants had a separate perineal opening. They can be classified as a particular form of Ikoma grade III necessitating surgical intervention.
OBJECTIVE: This study aimed to evaluate the impact of traditional Chinese medicine analgesic-assisted delivery patches on doula-assisted childbirth.
METHODS: We conducted a comparative analysis of two groups of puerperae. The control group consisted of 120 individuals who underwent routine delivery at Haian Hospital of Traditional Chinese Medicine between May 2019 and May 2020. The observation group included 120 puerperae who gave birth between June 2020 and June 2021, and they utilized Chinese medicine analgesic and childbirth-assisting patches in combination with doula-assisted childbirth. We compared both groups concerning childbirth outcomes, duration of labor, pain intensity, and postpartum hemorrhage.
RESULTS: In the observation group, the cesarean section rate was 12.50%, significantly lower than the 25.83% rate in the control group (P < .05). Additionally, the observation group exhibited shorter first and second labor times and total labor time compared to the control group (P < .05). Moreover, the NRS scores in the observation group were lower during both the latent and active phases of labor (P < .05). Furthermore, the observation group experienced reduced postpartum bleeding at 2 hours and 24 hours after delivery compared to the control group (P < .05).
CONCLUSIONS: The application of traditional Chinese medicine analgesics and delivery-aiding patches in doula-assisted childbirth significantly reduces the cesarean section rate. It contributes to improved childbirth outcomes, shortened labor durations, alleviation of labor pain, and reduced postpartum hemorrhage.
Headache is a common chief complaint of patients presenting to the emergency department (ED), accounting for approximately 3 million ED visits per year. Headache treatment is often a source of frustration for both patients and providers. By the time patients with benign headaches arrive in the emergency department, they have often failed non-invasive therapeutic attempts and providers are often left with few therapeutic options. Treatment of benign headache varies between providers, often including systemic medications with a multitude of possible side effects. Additionally, most headache cocktails require prolonged duration of treatment, occupying valuable bed space in increasingly busy emergency departments.

In recent years, there has been preliminary investigation into anesthetic injections for the undifferentiated headache patient presenting to the emergency department. It has been proposed that these patients presenting with benign headache might benefit from this novel treatment. Since 2003, paraspinal muscle injections of bupivacaine have been used in emergency department patients with encouraging results. The mechanism of action is not clearly understood; however, it has been proposed that these injections affect the trigeminocervical complex hypothesized to play an integral role in headache physiology, similar to the same mechanism behind greater occipital nerve blocks used by neurologists.

To the best of the investigators knowledge, there has never been a prospective double-blinded randomized control trial addressing this novel approach to headache management. Even so, the topic of using bupivacaine to inject the paraspinal musculature of the cervical spine has gained wider recognition over the past year. The topic has been discussed heavily on emergency medicine blogs and podcasts. Additionally, online videos have been posted to educate emergency medicine providers on the injection technique. According to retrospective literature, clinical efficacy was observed with a significant proportion of the patients receiving therapeutic effect. These studies, along with anecdotal experience with the procedure at the investigators institution, have led to great excitement concerning the possibility of a new approach to emergency department headache management. However, the topic still needs investigation with a well-designed prospective clinical trial to determine true clinical utility.
Emergency contraception (EC) provides women with an additional line of defense against unintended pregnancy during an act of unprotected intercourse. An antiprogestin, ulipristal acetate (UPA; ellaTM), has emerged as one of the most effective oral options. However, there is currently a lack of information regarding the practical use of UPA. Basic science studies have shown that UPA binds to and prevents progesterone receptor from working, leading to the possible concern that hormonal contraceptives, like the birth control pill, would prevent UPA from working. Ideally, women should start their regular method of birth control soon after EC use but by doing this, they may prevent the UPA EC from working. A woman could just delay starting her regular method of birth control but then she is still at risk for pregnancy.

This proposal has been designed to address this gap in knowledge and will focus on the impact of the birth control pill on UPA's ability to delay ovulation (or the release of an egg). Subjects will undergo a referent cycle UPA only (Cycle 1, 1 month), followed by a washout cycle (Cycle 2, 1 month) and finally UPA with combined oral contraceptives (COCs) dosed 2 days later (Cycle 3, 1 month treatment cycle). The hypothesis is that starting the birth control pill shortly after UPA adversely impacts UPA's ability to delay ovulation.
A phase change particulate saline slurry and methods and apparatus are provided for producing phase change particulates saline slurries. In one method for producing phase change particulates saline slurries (300), water and a first set amount of sodium chloride are provided to produce a saline solution (302). The saline solution is cooled to a set temperature (304). A selected percentage of chunk ice is broken into ice particles having a small size (306). Next a second set amount of sodium chloride is added and distributed for smoothing of the ice particles (308). If the slurry is to be used later, the slurry is stored in a highly insulated container while maintaining low level of slurry mixing for maintaining optimum slurry fluidity as indicated in block (310). The total saline solution concentrations resulting from the total of the first set amount and the second set amount of added sodium chloride are preferably in the range of about 0.5 % to 6.0 %. The loadings or percentage of ice particles are preferably in the range of 5 % to 50 % and have a size of about 1 mm or less and a generally smooth shape.
Black women are sorely underrepresented in studies of Alzheimer's disease and related dementias (ADRD) despite higher rates of ADRD diagnoses than in non-Hispanic White women. There are many reasons for underrepresentation, including medical mistrust, limited access to clinical studies, and restrictive study inclusion criteria. These pervasive barriers to research participation are often not considered during study development and, if eventually thought of tend to be after the fact. Community-engaged research (CER) approaches are an effective method for reducing participation barriers. This article describes how CER approaches were used to develop the Black Women Inflammation and Tau Study (BWITS), a prospective study to identify biopsychosocial risk factors for ADRD in Black women. Guidelines discussed here for future ADRD research in diverse populations are informed by Community-Based Participatory Research (CBPR), the National Institute on Minority Health and Health Disparities (NIMHD), and the Patient-Centered Outcomes Research Institute (PCORI). HIGHLIGHTS: Understand the historical tragedies related to medical practices and research designs that may contribute to the underrepresentation of Black Americans in research studies today. Highlight community-engaged research approaches that effectively reduce participation barriers in minoritized groups. Review Community-Based Participatory Research, National Institute of Minority Health and Health Disparities, and the Patient-Centered Outcomes Research Institute guidelines for conducting research with minoritized communities. Describe using the three frameworks to inform the study development protocol for the Black Women Inflammation and Tau Study. Conclude by offering study design considerations that we hope can be a helpful starting point for others conducting research with minoritized communities.