anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: The 2021 World Health Organization (WHO) guidelines on cervical cancer screening and treatment provide countries with evidence-based recommendations to accelerate disease elimination. However, evidence shows that health providers' adherence to screening guidelines is low. We conducted a study in Argentina to analyze health providers' knowledge and perceptions regarding the 2021 WHO Guidelines.
METHODS: A qualitative study was conducted based on individual, semi-structured interviews with health providers specializing in gynecology (n = 15). The themes explored were selected and analyzed using domains and constructs of the Consolidated Framework for Implementation Research.
RESULTS: Although health providers perceive WHO as a reliable institution, they do not know the 2021 guidelines, its supporting evidence, and its elaboration process. Their clinical practice is mainly guided by local recommendations developed by national professional medical associations (PMAs). For interviewees, WHO guidelines should be disseminated through health authorities and national PMAs, mainly through in-service training. Health providers had a positive assessment regarding WHO Recommendation 1 (screen, triage, and treatment for women aged 30 + with HPV-testing every 5 to 10 years) and perceived a favorable climate for its implementation. HPV-testing followed by triage was considered a low-complexity practice, enabling a better detection of HPV, a better selection of the patients who will need diagnosis and treatment, and a more efficient use of health system resources. However, they suggested adapting this recommendation by removing screening interval beyond 5 years. WHO Recommendation 2 (screen-and-treat approach with HPV-testing for women aged 30 + every 5 to 10 years) was predominantly rejected by interviewees, was considered an algorithm that did not respond to women's needs, and was not adequate for the Argentinean context. Regarding the HPV-test modality, clinician-collected tests were the preferred mode. Health providers considered that HPV self-collection should be used primarily among socially vulnerable women to increase screening coverage.
CONCLUSION: WHO guidelines should be widely disseminated among health providers, especially in settings that could benefit from a screen-and-treat approach. Identifying areas of partnership and collaboration with PMAs in implementing WHO guidelines is essential.
The present invention provides transgenic mice deficient in corticotropin releasing factor receptor 2. CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. Mutant mice had normal basal feeding and weight gain, but exhibited decreased food intake following food deprivation. Intravenous UCN has no effect on the mutant mice, but causes decreased arterial pressure in control animals. Deficiency in CRFR2 results in a significant increase in urocortin mRNA in the rostral region of the Edinger Westphal, and a significant increase in CRF mRNA in the central nucleus of the amygdala. These results demonstrate that CRFR2 mutant mice, as opposed to CRFR1 mutant mice, have an increased sensitivity to stress and display anxiety-like behavior.
Surgical needles are fabricated from a shape memory alloy. The alloy has a low temperature state, in which the needle is formable into an elongated shape to pass through an elongated tube, and a high temperature state, in which the needle forms an arc. The needle is particularly adapted for use in endoscopic surgery. A needle that has a remembered curved shape is straightened and passed to a surgical site through a cannula. It is then returned to its curved shape by heating it at the surgical site. After use, it is withdrawn through the cannula.
The long term prognosis for many children diagnosed with brain tumors and other malignancies has improved dramatically over the last decades and is expected to continue to rise as a result of improved treatment. The increased survival in pediatric oncology, however, has been associated with an increased recognition of neurobehavioral sequelae of cancer and its treatment. Current understanding of the incidence, pathogenesis, and natural history of these neurobehavioral abnormalities is limited and considerable individual variation in the presence and severity of these complications has been noted. Central nervous system (CNS) abnormalities associated with childhood cancer and its treatment have been demonstrated on at least three levels which may be interrelated: neurobehavioral abnormalities, brain imaging abnormalities, and neurotransmitter abnormalities.

Patients will be randomized to either clonidine or placebo. Study medication will be administered in a double blind fashion beginning with a four-week dose titration period followed by a four-week maintenance period. Total duration of dosing is 18 weeks. Patients who derive a benefit from clonidine administration may continue for an additional 30 weeks of therapy. PK samples will be collected at weeks 9 and 18.
The present invention relates to hair shampoo compositions comprising from about 5 % to about 30 % of a surfactant, from about 0.2 % to about 20 % of certain hair styling polymers, and from about 0.2 % to about 20 % of a solvent for said hair styling polymer. These compositions provide hair cleaning and styling benefits from a single product. Preferred compositions of the present invention additionally comprise from about 0.1 % to about 10 % of a silicone hair conditioning agent. These compositions provide hair conditioning, cleaning and styling benefits from a single product. The polymers which provide styling benefits are characterized by a Tg of greater than -20 C, and a solubility parameter, $g(d), of from 8.5 to 12.0. The solvent has a boiling point of less than or equal to 300 C and a solubility parameter, $g(d), of from 7 to 12.5. The ratio of polymer to solvent is from 20:80 to 80:20.
A probiotic composition comprising lactic acid bacteria is provided to increase immunity, normalize balance of intestinal flora, prevent and alleviate allergic disease such as skin allergy and food allergy, improve diabetes, control body weight, prevent adult disease such as hypertension, and enhance health of intestines. A probiotic composition comprises lactic acid bacteria containing 70-95 wt.% of at least one Lactobacillus sp. selected from Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus casei and Lactobacillus plantarum and 1-15 wt.% of at least one Bifidobacterium sp. selected from Bifidobacterium longum and Bifidobacterium breve, 0.1-10 wt.% of the extract of Acanthopanax senticosus and 0.1-10 wt.% of the extract of Perilla frutescens var. acuta leaf, and is formulated as powder, granule or capsule. Further, the lactic acid bacteria additionally comprise Streptococcus thermophilus.
A method, computer system, and a computer program product for automatically extracting and normalizing at least one mutant gene entity from at least one set of unstructured text is provided. The present invention may include extracting the unstructured text describing first and second entities. The present invention may then include identifying a specific first entity and a specific second entity. The present invention may also include associating the specific first and the specific second entities. The present invention may further include creating the mutant gene entity. The present invention may then include identifying at least one semantic relationship between the created mutant gene entity and one or more third entities. The present invention may further include storing the at least one set of data associated with the specific first and specific second entity, the semantic relationship, and the created mutant gene entity in a database.
The present invention relates to an extraction method for polygonatum polysaccharides, a preparation method for medical preparation and the usage thereof. The present invention has the extraction method for the polygonatum polysaccharides that polygonatum crude drug is chopped into small blocks to be added in 4 to 16 times of water, the polygonatum crude drug blocks are boiled and extracted for 1 hour to 4 hours, the extract is filtered, the residue is additionally added in 6 to 12 times of water to be boiled and extracted for 1 hour to 2 hours, the extract is filtered, and the two kinds of extract are combined to carry out centrifugal treatment. Obtained supernatant is decompressed and concentrated to the relative density of 1.08 to 1.25 (at the temperature of 45 to 60 DEG C.), the supernatant is placed to the room temperature to be added in 4 times to 8 times of 95% of ethanol solution to be stirred and settled for 12 hours to 48 hours, the precipitate is taken by separation, the precipitate is added in 0.5 to 2 times cold distilled water to be washed, and the precipitate is dissolved in the distilled water by heating, and 0.5 time to 4 times of 95% of ethanol is added for precipitation to be settled for 12 hours to 48 hours. The precipitate is taken and separated to be washed for three times by 0.5 time to 3 times of 95% of ethanol, and the alcohol lotion is discarded. After the precipitate is frozen and dried for a period of time, the precipitate is dried in a vacuum way to be dry at the temperature of 60 DEG C, the precipitate is taken out to be pulverized and white powder is obtained. The present invention has the preparation method for medical polygonatum polysaccharide preparation that the prepared polygonatum polysaccharide is added with proper auxiliary materials to be prepared into solid preparation classes of tablets, capsules, granules, buccal tablets, chewable tablets and dispersible tablets, and the polygonatum polysaccharide can also be prepared.
PURPOSE: To obtain an accelerator for formation of ice crystal for freezing of a biological material such as foods by culturing GRAS microorganisms subjected to transformation with a vector including genes which code the expression of a protein to accelerate formation of ice crystal. CONSTITUTION: GRAS microorganisms are transformed with a vector containing one or more kinds of genes which code the expression of a protein to promote formation of ice crystal. The transformed GRAS microorganisms are cultured in a proper culture medium to produce the protein which accelerates formation of ice crystal in the culture medium, and then the protein is collected from the medium. The obtd. protein can accelerate formation of ice crystal and is effective as an additive for formation of ice crystal in an edible biological material at <=0 deg.C. For example, an edible biological material such as vegetables, fruits and fish is treated with the additive above described and frozen by cooling to the temp. at which freezing begins.
Functional Electrical Stimulation (FES) is a rehabilitation tool that stimulates nerves via electrical current, causing muscles to contract. When FES is appled to leg muscles during stationary cycling the legs move in a fixed rhythmical pattern. Previous studies have demonstrated that FES during cycling is a safe and effective exercise for individuals recovering from spinal cord injury or stroke, but few have applied this tool to a progressive disorder, such as multiple sclerosis (MS). The aim of this study is to assess the immediate and short-term effect of an 8-week training program comparing FES lower extremity cycling to cycling without FES. Twenty volunteers with MS will participate. They will be randomly assigned to a training group. This study examine the effects of training on quality of life, endurance, walking speed, and step quality. Participants will sign an informed consent and complete a questionnaire that includes medical history and demographic data. Before training, immediately after training finishes and one month after training, self-report questionnaires, timed walking tests will be completed. During the walking tests, step quality and speed will be measured with a sensor that is worn on a belt
PURPOSE:To produce piperonal useful as an intermediate for perfume, agricultural chemicals and pharmaceuticals, with relatively simple process in high yield, by electrolyzing 3,4-methylenedioxybenzyl chloride. CONSTITUTION:Piperonal (other name: heliotropin) can be produced in high yield and selectivity by electrolyzing 3,4-methylenedioxybenzyl chloride of formula in water or a mixture of water and an organic solvent (e.g. benzene, methanol, etc.) in the presence of an electrolyte (e.g. sodium hydroxide). 3,4- Methylenedioxybenzyl chloride used as the starting material is obtained e.g. by the chloromethylation of methylenedioxybenzene.
The present invention relates to an iron family salt of dithiocarbamic acid, which is used as fishing medicines and belongs to the field of pesticide. The effective constituents of the new-type iron family metal salt of the dithiocarbamic acid accord with the general formula. Firstly, organic amine reacts with a solution of sodium hydroxide or potassium hydroxide, and then, carbon disulfide is slowly dripped in. Temperature is controlled to be lower than 35 DEG C; after the carbon disulfide stops being dripped, reaction continues to be carried out for 2 to 3 hours at the room temperature, and sodium salt or potassium salt intermediates of the dithiocarbamic acid are generated. The present invention is characterized in that in the general formula, M is metal iron or nickel, R is methylamine, dimethylamine, ethylamine, ethylenediamine, propylamine, propane diamine or isopropyl diamine, and n is 1, 1.5, 2 or 3. the sulfate (or chloride) of iron or nickel is added to the sodium salt or potassium salt intermediates of the dithiocarbamic acid, and double decomposition reaction is carried out to generate original drugs of iron or nickel salts of the dithiocarbamic acid. The technological progress of the present invention is very obvious, and the present invention has the advantages that the salt is favorable for ecological balance and environmental protection. The fishing medicines made according to the salt have the advantages of high drug effect and low toxicity, no pollutants are discharged in the preparation processes, and the present invention provides a green technique of environmental protection. In addition, obviously, besides meeting the application of high requirement fishing medicines, the iron family salt of dithiocarbamic acid is also suitable for crops.
The superficial palmar arch, formed by the branches of radial and ulnar arteries, supplies the blood to the hand. In cases of incomplete superficial palmar arch, the radial and ulnar branches fail to join. Any compromise to the ulnar blood supply in an incomplete superficial palmar arch can lead to subsequent gangrene. This baby presented with blackish discolouration and gangrene on the left hand, primarily affecting the little, ring, middle and index fingers. Timely intervention with antibiotics and heparinisation led to salvage of the ring, middle and index fingers, while the little finger underwent auto-amputation. On clinical exome sequencing, the baby was found to have DOCK6 mutation. This case highlights the importance of vascular involvement in DOCK6 mutation and the need for careful evaluation and management in cases of incomplete superficial palmar arch.
Background: Despite policies and guidelines recommending integration of health services in South Africa, provision of maternal and child health services remains fragmented. This study evaluated a rapid, scaleable, quality improvement intervention to improve integration of maternal and child health and HIV services at a primary health level, in KwaZulu-Natal, South Africa.

Methods: A three-month intervention comprised of six quality improvement mentoring visits, learning sessions with clinic staff to share learnings, and a self-administered checklist aimed to assist health workers monitor and implement an integrated package of health services for mothers and children. The study evaluated 27 clinics in four sub-districts using a stepped-wedge design. Each sub-district received the intervention sequentially in a randomly selected order. Five waves of data collection were conducted in all participating clinics between December 2016-February 2017. A multi-level, mixed effects logistic regression was used to account for random cluster fixed time and group effects using Stata V13.1.
Provided is a drug for preventing, alleviating or treating adhesion and a use thereof. A fibroblast which has been subjected to external stimulation in a body cavity contains an activated negative regulatory receptor PEAR1. The deletion of the fibroblast PEAR1 can significantly promote in vivo mucosal adhesion formation. A PEAR1 agonist can specifically inhibit fibroblast activation, synthesize an extracellular matrix, and ameliorate the adhesion lesion. By administering the PEAR1 agonist, the formation of adhesion can be effectively prevented. Also provided is a PEAR1 agonistic antibody that does not affect the repair and healing of normal tissue and does not cause the tissue to be in an anoxic state. Moreover, the antibody drug has a long half-life, is easily diffused, has few side effects, and has a convenient route of administration.
Aerosol compositions comprise an aluminium alcoholate, an organic solvent and a propellant, both the alcoholate and the propellant being soluble in the solvent.  The alcoholate is generally an aluminium alkoxide, e.g. the isopropoxide or butoxide or a mixture of isopropoxide and s-butoxide.  However, one or more of such lower alkoxy groups may be replaced by an alcoholate group derived from a compound such as oleyl alcohol, cetyl alcohol, polyethylene glycol or polyethylene glycol monomethyl ether.  Solvents specified are isopropanol and chloroform.  The propellant may be a fluorhydrocarbon or a gaseous hydrocarbon such as butane.  A corrosion inhibitor, e.g. acetone, may be included.  Boron alkoxides may also be present in the compositions.  Other optional ingredients include germicides, fungicides, filmforming substances, emollients and perfumes, those specified being hexachlorophene, pentachlorophenol, salicyclic acid, isopropyl myristate, menthol, 8-hydroxy quinoline, chloroxylenol, chlorobutanol, liquid paraffin and benzyl alcohol.  The aerosols may be applied to the skin as antiperspirants and fungicides, and for treating wounds and sores.ALSO:Aerosol preparations suitable for pharmaceutical use comprise an aluminium alcoholate, an organic solvent and a propellant, both the alcoholate and the propellant being soluble in the solvent. The alcoholate is generally an aluminium alkoxide, e.g. the isopropoxide or butoxide or a mixture of isopropoxide and s-butoxide.  However, one or more of such lower alkoxy groups in the alcoholate may be replaced by an alcoholate group derived from a compound such as oleyl alcohol, cetyl alcohol, polyethylene glycol or polyethylene glycol monomethyl ether. Solvents specified are isopropanol and chloroform.  The propellant may be a fluorohydrocarbon or a gaseous hydrocarbon such as butane. A corrosion inhibitor, e.g. acetone, may be included.  Boron alkoxides may also be present in the preparations.  Other optional ingredients include germicides, fungicides, film-forming substances, emollients and perfumes, those specified being hexachlorophene, pentachlorophenol, salicylic acid, isopropyl myristate, menthol, 8-hydroxyquinoline, chloroxylenol, chlorobutanol, liquid paraffin and benzyl alcohol.  The aerosols may be applied to the skin as antiperspirants, and fungicides, and for treating wounds and sores.
Lisinopril and hydrochlorothiazide tablet USP combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide.

Lisinopril, a synthetic peptide derivative, is an oral long-acting angiotensin converting enzyme inhibitor. It is chemically described as (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is C21H31N3O5•2H2O and its structural formula is:

Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water, sparingly soluble in methanol, and practically insoluble in ethanol.

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:

Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.72, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.

Lisinopril and hydrochlorothiazide tablets USP are available for oral use in three tablet combinations of lisinopril with hydrochlorothiazide: lisinopril and hydrochlorothiazide tablets USP, 10 mg/12.5 mg, containing 10 mg lisinopril and 12.5 mg hydrochlorothiazide; lisinopril and hydrochlorothiazide tablets USP, 20 mg/12.5 mg, containing 20 mg lisinopril and 12.5 mg hydrochlorothiazide; and lisinopril and hydrochlorothiazide tablets USP, 20 mg/25 mg, containing 20 mg lisinopril and 25 mg hydrochlorothiazide.

Inactive ingredients are dibasic calcium phosphate, magnesium stearate, mannitol, pregelatinized starch and starch (corn). Lisinopril and hydrochlorothiazide tablets USP, 10 mg/12.5 mg also contains FD&C Blue No. 2 Aluminum Lake. Lisinopril and hydrochlorothiazide tablets USP, 20 mg/12.5 mg also contains yellow iron oxide and lisinopril and hydrochlorothiazide tablets USP, 20 mg/25 mg also contain red iron oxide.
Cyclospora cayetanensis (C. cayetanensis) is a significant pathogen that causes diarrheal illness and causes large foodborne diarrhea outbreaks in the USA and Canada. However, there is currently a lack of published meta-analysis on the prevalence of C. cayetanensis infection in the global population. A real estimation of a disease prevalence should always be done on the basis of studies designed for that purpose. We conducted a comprehensive search of various databases for articles pertaining to the prevalence of C. cayetanensis infection in humans, spanning from the inception of these databases to March 10, 2023. Utilizing a random effects model, we estimated the prevalence of C. cayetanensis infection in humans. Our analysis included a total of 150 datasets sourced from 42 different countries, which were ultimately selected for the final quantitative assessment. The prevalence of C. cayetanensis infection in humans worldwide was estimated to be 3.4 % (5636/166,611). Notably, Africa exhibited the highest prevalence rate at 5.9 % (606/11,068). Further subgroup analysis revealed a significantly higher infection rate in humans residing in low-income countries (7.6 %, 83/921) compared to those in lower-middle-income countries (4.8 %, 3280/48,852), upper-middle-income countries (2.9 %, 2194/99,419), and high-income countries (0.4 %, 79/17,419). The results indicate that the global prevalence of C. cayetanensis infection in humans is relatively low, despite its extensive geographical distribution and children were found to be more susceptible to C. cayetanensis infection compared to those adults. Sensitivity analysis revealed that one study significantly affects the prevalence of C. cayetanensis, which was adjusted to 2.9 % (4017/160,049; 95 % CI: 2.7-3.1 %) by excluding this study. The findings highlight the relatively high prevalence of C. cayetanensis infection in low-income countries and among humans with diarrhea, particularly in Africa. Consequently, routine surveillance for intestinal protozoa is crucial in these regions.