anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Women with significant hypertension should not be started on hormonal contraception.92 An increase in blood pressure has been reported in women taking oral contraceptives68 and this increase is more likely in older oral contraceptive users69 and with extended duration of use.61 Data from the Royal College of General Practitioners12 and subsequent randomized trials have shown that the incidence of hypertension increases with increasing progestational activity.

Women with a history of hypertension or hypertension-related diseases, or renal disease70 should be encouraged to use another method of contraception. If these women elect to use oral contraceptives, they should be monitored closely and if a clinically significant persistent elevation of blood pressure (BP) occurs (≥ 160 mm Hg systolic or ≥ 100 mm Hg diastolic) and cannot be adequately controlled, oral contraceptives should be discontinued. In general, women who develop hypertension during hormonal contraceptive therapy should be switched to a non-hormonal contraceptive. If other contraceptive methods are not suitable, hormonal contraceptive therapy may continue combined with antihypertensive therapy. Regular monitoring of BP throughout hormonal contraceptive therapy is recommended.96 For most women, elevated blood pressure will return to normal after stopping oral contraceptives, and there is no difference in the occurrence of hypertension between former and never users.68–71
PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent capable of remarkably recovering muscle force of mdx mouse which is a model animal of Duchenne type progressive muscular dystrophy by including a complex of a specific natural dipeptide with zinc. SOLUTION: This therapeutic agent comprises polaprezinc as an active ingredient. Polaprezinc is a complex of L-calcinone which is a natural dipeptide discovered in muscle of human and muscle of many animals with zinc. The dose of polaprezinc to human is preferably 10-700 mg, especially 50-200 mg/adult. Solid preparation for oral administration of powder, granule, capsule, tablet, etc., in a form of mixture with proper vehicle, solution such as syrup or powder syrup or suspension as parenteral injection can be used as a dosage form. Polaprezinc is proved that acute toxicity, subacute toxicity and chronic toxicity are extremely low in experiments using animals and is already used as a therapeutic agent for stomach ulcer.
Congenital Diaphragmatic Hernia (CDH) is a complex developmental abnormality characterized by abnormal lung development, a diaphragmatic defect and cardiac dysfunction. Despite significant advances in management of CDH, mortality and morbidity continue to be driven by pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction. The etiology of CDH remains unknown, but CDH is presumed to be caused by a combination of genetic susceptibility and external/environmental factors. Current research employs multi-omics technologies to investigate the molecular profile and pathways inherent to CDH. The aim is to discover the underlying pathogenesis, new biomarkers and ultimately novel therapeutic targets. Stem cells and their cargo, non-coding RNAs and agents targeting inflammation and vascular remodeling have produced promising results in preclinical studies using animal models of CDH. Shortcomings in current therapies combined with an improved understanding of the pathogenesis in CDH have given rise to novel promising experimental treatments that are currently being evaluated in clinical trials. This review provides insight into current developments in translational research, ranging from the cellular origins of abnormal cardiopulmonary development in CDH and the identification of novel treatment targets in preclinical CDH models at the bench and their translation to clinical trials at the bedside.
NEW MATERIAL:An indane derivative expressed by formula I a or I b (R<2> and R<3> are H, lower alkyl or halogen, provided that R<2> and R<3> in formula I a are not H at the same time) and a salt thereof. EXAMPLE:7-Hydroxy-4-methyl-1-indanone oxime. USE:An antioxidant, having the ability to remove active oxygen species and prevent the formation of lipoperoxides in the living body, and specifically useful as an antiarteriosclerotic agent, carcinogenic preventing agent, carcinostatic agent, anti-inflammatory agent, analgesic agent and remedy for autoimmune diseases, etc. PREPARATION:A compound expressed by formula 2 is reacted with a compound expressed by formula 3 in the presence or absence of a basic compound, e.g. NaOH, in an inert solvent, e.g. methanol or dioxane, to afford the aimed compound expressed by formula I a, which is then catalytically hydrogenated in the presence of a catalyst, e.g. Pd, to give the compound expressed by formula I b.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to surgical dentistry, and can be used in dental implantations if observing insufficiency of a bone tissue of a dental process. For this purpose, an intervention is preceded by taking blood 10 ml from a patient's median cubital vein in 2-4 test tubes to be added with interleukin-2 at 100 IU per blood 10 ml. The prepared mixture is centrifuged at 2500 rpm for 10-10 min to form a FRP flap. A mineral component of the bone is the biotransplant Bio-Oss presoaked for 10 minutes in blood plasma prepared by centrifugation. It is followed by skeletonisation of the dental process within a defect of the bone tissue and decortication. After that, the FRP-flap covers the mineral component of the bone and closed. ^ EFFECT: method allows reducing time of postoperative wound repair, and also producing an adequate bone regenerate in a short period of time due to osteogenesis stimulation. ^ 1 ex
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to allergology, and can be applied for treatment of allergic rhinitis of domestic etiology. For this purpose in treatment included is allergen-specific immunotherapy with sublingual introduction of cause-significant allergen. Simultaneously hirudotherapy with application of medical leech on skin in region of oral cavity bottom projection is carried out. Procedures are carried out 2 times per week, starting from 0.1 ml 10-6 degree of dissolving of cause-significant allergen and bringing up to 0.5 ml of undissolved allergen, which after that is introduced 1 time per 2 weeks during 3 years. ^ EFFECT: invention allows to increase treatment efficiency due to increase of cause-significant allergen penetration into system of organs of mucosal immunity of upper airways. ^ 1 ex
This study aimed to enhance the fracture risk prediction accuracy in major osteoporotic fractures (MOFs) and hip fractures (HFs) by integrating genetic profiles, machine learning (ML) techniques, and Bayesian optimization. The genetic risk score (GRS), derived from 1,103 risk single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS), was formulated for 25,772 postmenopausal women from the Women's Health Initiative dataset. We developed four ML models: Support Vector Machine (SVM), Random Forest, XGBoost, and Artificial Neural Network (ANN) for binary fracture outcome and 10-year fracture risk prediction. GRS and FRAX clinical risk factors (CRFs) were used as predictors. Death as a competing risk was accounted for in ML models for time-to-fracture data. ML models were subsequently fine-tuned through Bayesian optimization, which displayed marked superiority over traditional grid search. Evaluation of the models' performance considered an array of metrics such as accuracy, weighted F1 Score, the area under the precision-recall curve (PRAUC), and the area under the receiver operating characteristic curve (AUC) for binary fracture predictions, and the C-index, Brier score, and dynamic mean AUC over a 10-year follow-up period for fracture risk predictions. We found that GRS-integrated XGBoost with Bayesian optimization is the most effective model, with an accuracy of 91.2% (95% CI: 90.4-92.0%) and an AUC of 0.739 (95% CI: 0.731-0.746) in MOF binary predictions. For 10-year fracture risk modeling, the XGBoost model attained a C-index of 0.795 (95% CI: 0.783-0.806) and a mean dynamic AUC of 0.799 (95% CI: 0.788-0.809). Compared to FRAX, the XGBoost model exhibited a categorical net reclassification improvement (NRI) of 22.6% (P = .004). A sensitivity analysis, which included BMD but lacked GRS, reaffirmed these findings. Furthermore, portability tests in diverse non-European groups, including Asians and African Americans, underscored the model's robustness and adaptability. This study accentuates the potential of combining genetic insights and optimized ML in strengthening fracture predictions, heralding new preventive strategies for postmenopausal women.
Anesthesiologist based perioperative intravenous remifentanil administration (daily practice, standard of care). Starting dose 5 ng/ml, dosage adjustments are made when deemed necessary by attending anesthesiologist.
PURPOSE: To reduce a blind inspection value in immunoanalysis by processing a porous carrier material with a wetting boosting agent. CONSTITUTION: A fiber material made of polyester and sulfite pulp is crushed and beaten and is swollen by such wetting boosting agent as polyamidoamine- epichlorohydrin resin. A generated fiber slurry is fed onto an inclined filtering net by a pump. The fiber remaining on the filtering net is moved to a drying machine and is dried. An immunocomplex is adsorbed on the porous carrier material thus manufactured by immunosettlement, thus manufacturing immunoreactive porous carrier material. For processing the porous carrier material with the wetting boosting agent, the solution of the wetting boosting agent may be dipped into the porous carrier material. Since the manufactured immunoreactive porous carrier material is strongly adhered to the immunocomplex, no immunocomplex flows between immunological tests.
Home-based rehabilitation sessions provided by a Physical Therapist, 3 times a week, each with 1h duration. Patients will be instructed to perform 2 additional unsupervised sessions per week, but compliance to these sessions is not mandatory.
Following topical application, tazarotene undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid.

Systemic exposure following topical application of DUOBRII Lotion was evaluated in the same study that evaluated the HPA axis suppression. It was an open-label, randomized, pharmacokinetics (PK) study conducted in subjects aged 18 years and older with moderate to severe plaque psoriasis affecting at least 20% body surface area. The PK of halobetasol propionate, tazarotene, and tazarotenic acid was evaluated in 22 subjects following application of DUOBRII Lotion to the affected area once daily for 28 days. Systemic concentrations of halobetasol propionate (lower limit of quantification (LLOQ) = 50 pg/mL) and tazarotene (LLOQ = 5 pg/mL) on Day 28 were quantifiable in 13 and 18 out of a total number of 22 subjects, respectively. Tazarotenic acid (LLOQ = 5 pg/mL) was quantifiable in all subjects. Systemic exposure of the three moieties was at or near steady state by Day 28. The mean (standard deviation) of PK parameters on Day 28 is shown in Table 2.
The central hypothesis of this study is that immune responses to vaccination can be quantified by proteomic profiling of serum (and other clinical fluids), and that the host responses to different infectious agents are unique and can be 'fingerprinted' by proteomics. Using influenza virus vaccination, this study proposes to use mass spectrometry platforms to profile and characterize proteins from serum samples obtained from recipients. These samples will be used to develop a proteomic profiling system for monitoring vaccine response and, eventually, early detection/diagnosis of infection. The long-term goal of this approach is to develop tools useful for reducing the morbidity and mortality of influenza from natural and potential bioterrorism-related infections by improving measures of vaccine efficacy and early diagnosis. The primary objective is to use surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry proteomic profiling tools to analyze a series of serum samples obtained from cohorts of young and elderly subjects, before and after trivalent split-virus influenza vaccination, to identify surrogate markers reflective of the immune response. The secondary objective is to use concurrent T-cell activation, cytokine assays, and hemagglutination inhibition (HI) serologic assays to correlate cellular and humoral responses to influenza vaccination with protein profiling changes. Comparisons of the protein profile data with the T-cell activation, cytokine assays, and HI results will be evaluated using multiple classification algorithms, and potential biomarker proteins will be identified by sequencing with either a MALDI-TOF or electrospray ionization mass spectrometer. Study Participants will include healthy adult volunteers between the ages of 21-40, between the ages of 60-89, or 90 years and older, who are living independently in the communities surrounding the 3 study sites in Virginia. There will be 5 study visits, and subjects will be in the trial for up to 1 month. The primary endpoint of the study is to identify surrogate markers reflective of the immune response and to correlate these markers to cellular and humoral responses (demonstrated with T-cell activation, cytokine assays, and the HI serologic assays) to influenza vaccination. The secondary endpoint is safety. Data on the following solicited local reactions (injection site pain, bruising, redness, tenderness, and induration) and solicited systemic reactions (fever, headache, malaise, myalgia, cough, runny nose, chills, vomiting, arthralgia, rash, and diarrhea) will be collected from Day 0-Day 14 and categorized as none, mild, moderate, and severe. Unsolicited adverse events (including serious adverse events) will be collected and categorized throughout the study by severity, duration, and relatedness to the vaccine.
OBJECTIVE: While subjective methods like the Yanagihara system and the House-Brackmann system are standard in evaluating facial paralysis, they are limited by intra- and inter-observer variability. Meanwhile, quantitative objective methods such as electroneurography and electromyography are time-consuming. Our aim was to introduce a swift, objective, and quantitative method for evaluating facial movements.
METHODS: We developed an application software (app) that utilizes the facial recognition functionality of the iPhone (Apple Inc., Cupertino, USA) for facial movement evaluation. This app leverages the phone's front camera, infrared radiation, and infrared camera to provide detailed three-dimensional facial topology. It quantitatively compares left and right facial movements by region and displays the movement ratio of the affected side to the opposite side. Evaluations using the app were conducted on both normal and facial palsy subjects and were compared with conventional methods.
RESULTS: Our app provided an intuitive user experience, completing evaluations in under a minute, and thus proving practical for regular use. Its evaluation scores correlated highly with the Yanagihara system, the House-Brackmann system, and electromyography. Furthermore, the app outperformed conventional methods in assessing detailed facial movements.
CONCLUSION: Our novel iPhone app offers a valuable tool for the comprehensive and efficient evaluation of facial palsy.
Exercise group. Physical exercise intervention with sessions carried out as circuit-training, three times a week for 12 weeks to improve physical fitness and metabolic control. The sessions will last between 10 and 45 minutes.
BACKGROUND: Although randomized controlled trials (RCTs) have shown that calcitonin gene-related peptide (CGRP)-targeted monoclonal antibodies (CGRP mAbs) are an efficacious and safe therapeutic modality for migraine prevention, their clinical benefits have not been well validated in Japanese patients in the real-world setting. The present study aimed to evaluate the real-world efficacy and safety of galcanezumab, fremanezumab, and erenumab in Japanese patients with migraine.
METHODS: This observational retrospective cohort study was conducted at two headache centers in Japan. Patients with migraine who had experienced treatment failure with at least one traditional oral migraine preventive agent were treated with a CGRP mAb de novo. The primary efficacy endpoints were the changes from baseline in monthly migraine days (MMDs) and Headache Impact Test-6 (HIT-6) score after 3 dosing intervals (V3). We explored whether demographic and clinical characteristics predicted therapeutic outcomes at V3.
RESULTS: Sixty-eight patients who completed three doses of a CGRP mAb (85.3% female [58/68], mean age: 46.2 ± 13.1 years) were included in the analysis. There were 19 patients with chronic migraine. The baseline MMDs were 13.4 ± 6.0. After 3 doses, the MMDs significantly decreased to 7.4 ± 5.5 (p < 0.0001), and the 50% response rate was 50.0%. HIT-6 score was significantly reduced from 66.7 ± 5.4 to 56.2 ± 8.7 after 3 doses (P = 0.0001). There was a positive correlation between the changes in MMDs and HIT-6 score from baseline after 2 doses (p = 0.0189). Those who achieved a ≥ 50% therapeutic response after the first and second doses were significantly more likely to do so at V3 (crude odds ratio: 3.474 [95% CI: 1.037 to 10.4], p = 0.0467). The most frequent adverse event was constipation (7.4%). None of the adverse events were serious, and there was no need for treatment discontinuation.
CONCLUSIONS: This real-world study demonstrated that CGRP mAbs conferred Japanese patients with efficacious and safe migraine prevention, and an initial positive therapeutic response was predictive of subsequent favorable outcomes. Concomitant measurement of MMDs and HIT-6 score was useful in evaluating the efficacy of CGRP mAbs in migraine prevention.
AIMS: The availability of novel lipid-lowering therapies (LLTs) has remarkably changed the clinical management of homozygous familial hypercholesterolaemia (HoFH). The impact of these advances was evaluated in a cohort of 139 HoFH patients followed in a real-world clinical setting.
METHODS AND RESULTS: The clinical characteristics of 139 HoFH patients, along with information about LLTs and low-density lipoprotein cholesterol (LDL-C) levels at baseline and after a median follow-up of 5 years, were retrospectively retrieved from the records of patients enrolled in the LIPid transport disorders Italian GEnetic Network-Familial Hypercholesterolaemia (LIPIGEN-FH) Registry. The annual rates of major atherosclerotic cardiovascular events (MACE-plus) during follow-up were compared before and after baseline. Additionally, the lifelong survival free from MACE-plus was compared with that of the historical LIPIGEN HoFH cohort. At baseline, LDL-C level was 332 ± 138 mg/dL. During follow-up, the potency of LLTs was enhanced and, at the last visit, 15.8% of patients were taking quadruple therapy. Consistently, LDL-C decreased to an average value of 124 mg/dL corresponding to a 58.3% reduction (Pt < 0.001), with the lowest value (∼90 mg/dL) reached in patients receiving proprotein convertase subtilisin/kexin type 9 inhibitors and lomitapide and/or evinacumab as add-on therapies. The average annual MACE-plus rate in the 5-year follow-up was significantly lower than that observed during the 5 years before baseline visit (21.7 vs. 56.5 per 1000 patients/year; P = 0.0016).
CONCLUSION: Our findings indicate that the combination of novel and conventional LLTs significantly improved LDL-C control with a signal of better cardiovascular prognosis in HoFH patients. Overall, these results advocate the use of intensive, multidrug LLTs to effectively manage HoFH.
Stroke is the third leading cause of death in the United States and other developed countries and a major source of disability, often leading to hospitalization. Prognosis for regaining the ability to walk is good, with 64% of those initially dependent in walking regaining independence by three months. However, many gait abnormalities persist.

Reduced hip, knee and ankle excursions during swing are among the persistent gait abnormalities contributing to poor or inefficient limb clearance. This is generally referred to as "foot drop", since the foot drops or drags along the ground during the swing phase. Swing phase abnormalities can result in decreased velocity, limited endurance and an increased risk for falls. These factors can limit mobility and independence in the community. Therefore, intervention is warranted.

The conventional approach to address the poor swing limb function, specifically, insufficient ankle dorsiflexion, is the prescription of an ankle-foot orthosis (AFO). An AFO commonly limits ankle plantarflexion to enhance limb clearance during swing. An alternative approach is to stimulate the ankle dorsiflexors electrically during swing phase to reproduce motion, which can no longer be performed volitionally.

The WalkAide is a new foot drop stimulator. This small, self-contained device attaches to the leg below the knee. The WalkAide contains a number of patented features, including a tilt sensor that measures the orientation of the leg with respect to the vertical. When the leg is tilted back at the end of stance, stimulation of the common peroneal nerve is initiated. This produces flexion of the ankle and other joints (if a flexion reflex is elicited) so that the leg can clear the ground during swing. When the leg is tilted forward at the end of swing phase, the stimulus is terminated. The electrodes attach to the inside of a cuff that is molded to the leg for reproducible positioning from day to day. The device is also designed so that all operations can be done with a single hand, since hemiparesis may prevent the subject from using the other hand. Because of its enhanced features, the WalkAide is anticipated to increase walking speed and improve the quality of life.
A system for utilizing artificial intelligence for facilitating physician assessment is provided. The system interacts with a user to obtain information from the user, which is then provided to an artificial intelligence engine to predict an assessment and generate a digital record for the user including a plan for the user. The engine compares the predicted assessment to standing order protocols and provider standards protocols to determine if there is a match. If there is a match, instructions according to the protocols are executed. Otherwise, the system places the digital record containing the assessment in a worklist for further review to determine a workflow for the assessment. The workflow instructs the user to proceed directly to an emergency room, schedule a consultation with a provider, or to have the assessment reviewed by a provider. The digital record is updated and provided to the user, third parties, and billing systems.
Two intranasal sprays of tetracaine HCl and oxymetazoline HCl nasal spray anesthetic administered 4 minutes apart into the nostril corresponding to the side of the treated tooth. If inadequate anesthetic response obtained within 10 minutes, a third spray will be administered and assessed for effective anesthesia after 4 minutes.
Omeprazole delayed-release capsules USP 10 mg are hard gelatin capsules with a pink opaque body and a reddish brown opaque cap. “APO 010” is imprinted on each capsule in black ink. 

Omeprazole delayed-release capsules USP 20 mg are hard gelatin capsules with a pink opaque body and a reddish brown opaque cap. “APO 020” is imprinted on each capsule in black ink. 

Omeprazole delayed-release capsules USP 40 mg are hard gelatin capsules with a pink opaque body and a reddish brown opaque cap. “APO 040” is imprinted on each capsule in black ink.