anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several physiological and pathological processes. Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms, which have been confirmed to be closely related to oncogenesis. The concept of intratumoural microbiota was subsequently proposed. Microbiota could colonise tumour tissues through mucosal destruction, adjacent tissue migration, and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment. Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations, affecting epigenetic modifications, promoting inflammation response, avoiding immune destruction, regulating metabolism, and activating invasion and metastasis. Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging, new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination. In addition, interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy, especially immunotherapy, although there are some inevitable challenges. Here, we aim to provide an extensive review of the concept, development history, potential sources, heterogeneity, and carcinogenic mechanisms of intratumoural microorganisms, explore the potential role of microorganisms in tumour prognosis, and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field.
Curcumin compositions are described for administration to healthy subjects, in need thereof, for improving cardiovascular flow. Curcumin compositions described herein can be administered to a subject in an effective dose of 250 mg to 1000 mg, corresponding to about 50 mg to 200 mg curcuminoids, for improvement of endothelial function and reducing risk of cardiovascular diseases. Compositions herein include curcumin either alone or curcumin along with at least one excipient to enhance absorption. Compositions herein improve endothelial function in healthy subjects having FMD value of 5-7% or higher and who are not diagnosed with cardiovascular disease. Compositions herein also improve cardiovascular endothelial function by reducing vascular resistance and enhancing nitric oxide generation in vascular endothelium. Curcumin compositions herein are safe for consumption, possesses enhanced absorption and can be employed for improvement of endothelial function and cardiovascular flow, when administered in an effective dose to a healthy subject, in need thereof.
Urinary tract infections vary widely in their clinical spectrum, ranging from uncomplicated cystitis to septic shock. Urosepsis accounts for 9-31% of all cases of septicemia and is often associated with nosocomial infections. A major risk factor for urosepsis is the presence of obstructive uropathy, caused by conditions such as urolithiasis, tumors, or strictures. The severity and course of urosepsis depend on both the virulence of the pathogen and the patient's specific immune response. Prompt therapy, including antimicrobial treatment and eradication of the infection source, along with supportive measures for circulatory and respiratory stabilization, and adjunctive therapies such as hemodialysis and glucocorticoid therapy, is crucial. Due to demographic changes, an increase in cases of urosepsis is expected-thus, it is of utmost importance for urologists to be familiar with targeted diagnostics and effective treatment.
<P>PROBLEM TO BE SOLVED: To provide a method for mass-culturing/producing any of various pathogenic microbes as a raw material for vaccines for infectious animal diseases or antigens for infection diagnoses in an efficient step by using a suspendible cultured cell line capable of continuous suspension culture which is created from a normal adhesive monolayer cultured cell line sensitive to various pathogenic microbes including pathogenic virus.  <P>SOLUTION: The suspendible cultured cell line is a canine kidney-derived one which is created from a canine kidney-derived adhesive monolayer cultured cell line. The canine kidney-derived suspendible cultured cell line is either a cell line deposited as an accession No. of FERM P-18443 or a cell line having biological properties equivalent to those thereof. Suspension culture of the cell line enables the efficient mass production of the aimed pathogenic microbes.  <P>COPYRIGHT: (C)2003,JPO
Early research on hip arthroscopy for femoroacetabular impingement syndrome identified patient age as a risk factor for poor outcomes and heightened revision rates. However, more recent research challenges this dogma. Disparities between chronologic and physiologic age exist among patients. In addition, orthopaedic pathology (such as degenerative chondral or labral pathology) can correlate with age, so the use of age, and using age as a predictor of outcome, may be biased by this confounding effect. Older patients without degenerative joint disease can have excellent outcomes after hip arthroscopy. Recent research shows that patients older than the age of 40 years undergoing hip arthroscopy for femoroacetabular impingement syndrome demonstrate outcomes comparable with younger patients at 10-year follow-up. However, older patients were at greater risk for conversion to total hip arthroplasty. In our experience, in the absence of joint degeneration, patients older than the age of 40 years experience predictable and durable relief following arthroscopic management of femoroacetabular impingement syndrome. These outcomes result from sound surgical indications, appropriate preoperative counseling, and meticulous surgical technique. We ought not replace joints we can preserve, and age is not the most determinative factor regarding outcome of otherwise well-indicated and performed hip arthroscopy.
PURPOSE:To obtain a bland nitroglycerin oral cavity preparation by blending nitroglycerin with a carrier having affinity for nitroglycerin, adsorbing or dispersing the blend into a water-soluble polymer and powdering, maintaining controlled release. CONSTITUTION:Nitroglycerin (GTN for short) is dissolved in ethanol to give an ethanol solution and a substance having affinity for GTN such as alcohol- soluble saccharide, a saccharide derivative, a dextrin and GTN-soluble fats and oils are dispersed or dissolved in the ethanol solution. Ethanol is removed. Then the resultant substance is adsorbed or dispersed into a water-soluble polymer and powdered to give a bland nitroglycerin oral cavity preparation. This oral cavity preparation has no characteristic irritating feeling (smart feeling) of GTN and maintains controlled release. The oral cavity preparation will not cause dysgeusia and tumor of oral cavity tissue resulting from continuous use and has excellent stability with time.
The study is a randomized, controlled trial (RCT) that will examine the effectiveness of an intervention designed to support and enhance community participation for adults with serious mental illness (SMI) receiving community mental health services. The intervention is based on two evidence-based strategies. The first is the patient navigation interventions, which are used to assist people with SMI to identify and overcome barriers to accessing care. The second is the Capability, Opportunity, Motivation model of behavior change (COM-B model) which evaluates how each of these factors influences behavior. Participants will be assigned to one of two groups, the Community Navigator condition, or a control group. Those in the intervention arm will develop a community support plan with a peer support specialist community navigator and those in the control arm will receive printed information on the importance, skills, and opportunities for participation. Over the course of the 6-month intervention, participants in the intervention arm, with support from the peer support specialist will develop an initial participation plan, and through weekly meetings online or in-person will monitor their progress and make changes as needed. Recruitment will occur only in Philadelphia in collaboration with residential treatment service providers including: Merakey, Horizon House, COMHAR, Inc, and potential others. Data collection for all participants will take occur at baseline and at the end of the 6-month intervention. We aim to recruit and enroll 96 participants for a 16-month period in a randomized control trial of a community navigation intervention. Participants will be randomly assigned to either the intervention or an informational control group. The intervention group will meet with a peer support specialist once a week for 60-90 minutes. Enrollment will occur over 16 months, with 6 participants joining each month from behavioral health residential service sites. Each participant will have two meetings with a research assistant - an intake interview and an exit interview after 6 months. The primary analyses are expected months after the study initiation.

The aim of the research study is to determine the efficacy of a peer-support intervention to navigate community opportunities and resource to increase participation among adults with SMI and to determine if participation in the intervention increases social connections and decreases loneliness. The existing navigation approaches in health care have employed peer-delivered services and demonstrated significant effects. The program theory of this intervention is based on existing models of peer-delivered health navigation approaches.
Patients in Arm A will continue with S-1 de-escalation phase starting at week 13 until disease progression, toxicities requiring discontinuation, withdrawal of consent, pregnancy, death or lost to follow up whichever occurs first. In patients with drug-related severe toxicity S-1 dose will be adjusted or study treatment will be terminated.
The investigators placed a wired monitoring system (pulse oximetry, heart rate and respiratory rate) on every patient who arrived on a subject general post surgical ward who assented to wear the system. this was the Masimo PSNET system using the Radical 87 monitor and an acoustic respiratory sensor along with a Masimo pulse oximetry probe. Patients were monitored for a minimum of 48 hrs. Heart Rate (HR) parameters were set between 45-130, Respiratory rate was set between 6-20 and pulse oximetrry was 85-100%. Nurses documented in the Electronic Medical Record (EMR) any alarms they responded to as to whether they were false (vital sign not out of range when rechecked) or true and what the response was. Responses ranged from nurse managed to notification of primary service to Rapid Response Activation to Code team activation as well as transfer to a higher level of care (operating room or Intensive Care Unit (ICU)/IMC. Patient and Nursing satisfaction surveys were collected.
Brown adipose tissue (BAT) recently emerged as a novel player in energy expenditure (EE) in humans as it combusts fatty acids and glucose towards heat. Human BAT can be activated by sympathetic stimulation resulting from cold exposure or treatment with sympathomimetic drugs. Short-term acclimation to mild cold was shown to reduce fat mass in obese subjects and decrease peripheral insulin resistance of patients with T2DM. Recently, in preclinical studies the investigators showed that BAT has a circadian rhythm. It is currently unknown whether this is also the case in humans. The investigators postulate that BAT activity should display a circadian rhythm that adapts to changes in circadian behavior, and may determine glucose/lipid levels throughout the day.
FIELD: cosmetic industry. SUBSTANCE: method of oxidizing coloring of man's keratin fibers involves applicating on fibers composition (A) containing in medium suitable for coloring at least one predecessor of oxidizing color and, if necessary, one or some color-forming components in showing of color in alkali, neutral or acid medium with the help of oxidizing composition (B) containing an oxidizer. At least one of compositions (A) and (B) contains effective quantity of at least one amphiphilic cation polymer selected from quaternized celluloses modified with the help of groups containing at least one fat chain selected from alkyl, arylalkyl, alkylaryl groups containing at least eight atoms of carbon or their mixtures, and from quaternized hydrooxyethylcelluloses modified with the help of groups containing at least one fat chain. Compositions (A) and (B) are mixed just before application or apply one after another on fibers. EFFECT: provision of brighter color tones. 22 cl
The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their molecular links remain unclear. Here, utilizing Schnurri-3-/- (Shn3-/-) mice with augmented osteoblast activity, we show Shn3-/-mice display resistance against diet-induced obesity and enhanced white adipose tissue (WAT) browning. Conditional deletion of Shn3 in osteoblasts but not adipocytes recapitulates lean phenotype of Shn3-/-mice, indicating this phenotype is driven by skeleton. We further demonstrate osteoblasts lacking Shn3 can secrete cytokines to promote WAT browning. Among them, we identify a C-terminal fragment of SLIT2 (SLIT2-C), primarily secreted by osteoblasts, as a Shn3-regulated osteokine that mediates WAT browning. Lastly, AAV-mediated Shn3 silencing phenocopies the lean phenotype and augmented glucose metabolism. Altogether, our findings establish a novel bone-fat signaling axis via SHN3 regulated SLIT2-C production in osteoblasts, offering a potential therapeutic target to address both osteoporosis and metabolic syndrome.
Mutations in the PQBP1 gene (polyglutamine-binding protein-1) are responsible for a syndromic X-linked form of neurodevelopmental disorder (XL-NDD) with intellectual disability (ID), named Renpenning syndrome. PQBP1 encodes a protein involved in transcriptional and post-transcriptional regulation of gene expression. To investigate the consequences of PQBP1 loss, we used RNA interference to knock-down (KD) PQBP1 in human neural stem cells (hNSC). We observed a decrease of cell proliferation, as well as the deregulation of the expression of 58 genes, comprising genes encoding proteins associated with neurodegenerative diseases, playing a role in mRNA regulation or involved in innate immunity. We also observed an enrichment of genes involved in other forms of NDD (CELF2, APC2, etc). In particular, we identified an increase of a non-canonical isoform of another XL-NDD gene, UPF3B, an actor of nonsense mRNA mediated decay (NMD). This isoform encodes a shorter protein (UPF3B_S) deprived from the domains binding NMD effectors, however no notable change in NMD was observed after PQBP1-KD in fibroblasts containing a premature termination codon. We showed that short non-canonical and long canonical UPF3B isoforms have different interactomes, suggesting they could play distinct roles. The link between PQBP1 loss and increase of UPF3B_S expression was confirmed in mRNA obtained from patients with pathogenic variants in PQBP1, particularly pronounced for truncating variants and missense variants located in the C-terminal domain. We therefore used it as a molecular marker of Renpenning syndrome, to test the pathogenicity of variants of uncertain clinical significance identified in PQPB1 in individuals with NDD, using patient blood mRNA and HeLa cells expressing wild-type or mutant PQBP1 cDNA. We showed that these different approaches were efficient to prove a functional effect of variants in the C-terminal domain of the protein. In conclusion, our study provided information on the pathological mechanisms involved in Renpenning syndrome, but also allowed the identification of a biomarker of PQBP1 deficiency useful to test variant effect.
Subjects will use 10% benzoyl peroxide twice daily. The product will be applied to the affected areas, left on for 45 seconds, then rinsed off.
The invention belongs to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine for preventing and treating cancer and a preparation method thereof, wherein the components of the traditional Chinese medicine comprise 1-4 parts of (fried) dandelion root and 0.5-2 parts of snakegourd fruit. The invention contains two medicinal materials of dandelion root (fried) and snakegourd fruit. The medicinal preparation, PUGUA RUANJIANGXIAOJI granule, aims at removing qi stagnation, dissipating heat, eliminating carbuncle and swelling, and removing phlegm and saliva. For treating subcutaneous nodule scrofula, sore, furuncle, carbuncle and swelling, has obvious functions of clearing heat and detoxicating, softening hardness and dissipating stagnation, has definite curative effect and good curative effect on cancers such as lung cancer, intestinal cancer and the like, and has the advantages of safe eating and no adverse reaction because the dandelion root (fried) and the snakegourd fruit are both medicinal and edible varieties. The medicine has wide medicine source, simple production process and lower price than other treatment medicines, and is popular to the common people. The product provides a safe and reliable pure Chinese medicinal preparation for treating lung cancer and intestinal cancer, is very suitable for preventing and treating cancer, and has wide popularization and application prospects.
The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium breve capable of relieving constipation and application thereof. The bifidobacterium breve is preserved in China general microbiological culture Collection center (CGMCC) with the preservation number of CGMCC No.24982. The bifidobacterium breve provided by the invention can promote the intestinal tract vermiculity of a constipation mouse and relieve the damage of constipation to intestinal tracts. In addition, bifidobacterium breve can accelerate small intestine peristalsis and shorten fecal time in the small intestine by modulating gastrointestinal hormones associated with constipation. Can also regulate the content of inflammatory factors and the mRNA level of constipation-related genes. Therefore, the bifidobacterium breve has better application prospect in the preparation of health care products and the clinical treatment and alleviation of constipation.
<P>PROBLEM TO BE SOLVED: To obtain a hair setting agent readily coating the hair received damage and imparting sufficient setting force, and to provide a method for using the agent.  <P>SOLUTION: The hair setting agent is composed of a first agent and a second agent. The first agent comprises (A) an amino-modified silicone and (B) a volatile oil. The second agent comprises (C) waxes. Furthermore, a cationic compound other than the amino-modified silicone (A) is preferably contained as the ingredient (D) in the first agent. Each ingredient of (A) and (B) selected from each of the ingredients (A), (B) and (C) is preferably contained only in the first agent. The ingredient (C) selected from each of the ingredients (A), (B) and (C) is preferably contained only in the second agent. When the first and the second agents are used, the hair is coated with the first agent and then coated with the second agent.  <P>COPYRIGHT: (C)2004,JPO
Ureteroscopic lithotripsy for impacted stones is challenging, but it is important to predict impacted stones preoperatively. Hydronephrosis, which is evaluated by a grading system, is often apparent in impacted stones. However, the currently used grading system is a qualitative evaluation. We, therefore, focused on a quantitative evaluation: the area of hydronephrosis. The aim of this study was to investigate whether the area of hydronephrosis could predict impacted stones more accurately than Society for Fetal Urology grade. We retrospectively identified 160 patients who underwent ureteroscopic lithotripsy for ureteral stones at our hospital between January 2014 and April 2022. Impacted stones were defined as stones fixed to the ureteral wall that could not be moved by means of ureteroscopic manipulation or water pressure. Of the 160 patients, 54 (33.8%) had impacted stones. Comparing patient characteristics, there were significant differences in stone size, ureteral wall thickness, Society for Fetal Urology grade, renal pelvic width and area of hydronephrosis (all P < 0.01). Receiver operating characteristic analysis showed that area of hydronephrosis was the more significant predictive value (area under the curve 0.781) compared with Society for Fetal Urology grade (area under the curve 0.676, P < 0.01). Multivariate analysis revealed that significant independent predictive factors of impacted stones were thicker ureteral wall thickness and larger area of hydronephrosis (both P < 0.01). The area of hydronephrosis and ureteral wall thickness were significant predictors of impacted stones in patients undergoing ureteroscopic lithotripsy for ureteral stones. These factors may be useful for selecting the treatment and preoperative settings.
In the 3T arm, patients were stimulated with a carrier wave of 25 KHz and biphasic modulations of the pulse train of 40 Hz. Anxious patients trained at first only in the biofeedback mode. The stimulation was introduced after four weeks for these patients. Patients were instructed to carry out the training at home, with an alternating combination in the morning and with EMG-triggered stimulation in the evening, each for 20-minute periods. Apart from this, the protocol of the active treatment group was identical to that of the control group.
### Pregnancy Category B

The disposition of 14C-clotrimazole has been studied in humans and animals. Clotrimazole is very poorly absorbed following dermal application or intravaginal administration to humans. (See CLINICAL PHARMACOLOGY.)

In clinical trials, use of vaginally applied clotrimazole in pregnant women in their second and third trimesters has not been associated with ill effects. There are, however, no adequate and well-controlled studies in pregnant women during their first trimester of pregnancy.

Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to clotrimazole.

High oral doses of clotrimazole in rats and mice ranging from 50 to 120 mg/kg resulted in embryotoxicity (possibly secondary to maternal toxicity), impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. However, clotrimazole was not teratogenic in mice, rabbits and rats at oral doses up to 200, 180 and 100 mg/kg respectively. Oral absorption in the rats amounts to approximately 90% of the administered dose.

Because animal reproductive studies are not always predictive of human response, this drug should be used only if clearly indicated during the first trimester of pregnancy.
Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy and 2 years after the last menstrual period. The patient was brought to the emergency room of a tertiary care centre in Muscat, Oman, in 2022 and was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 mIU/mL). The International Federation of Gynecologic Oncology risk score was calculated to be 14 (very high risk). The patient was initially treated with whole-brain radiotherapy and splenic artery embolisation because of a hemoperitoneum. Afterwards the patient received systemic treatment using the standard EMA/CO regimen till complete serological remission.