anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A non-instrumental assay for the diagnosis of celiac disease based on the general immunochromatographic assay principles. The assay is rapid and simple and allows the reliable detection of anti transglutaminase antibodies, of both IgA and IgG isotype, in samples of human serum, plasma or blood, using as tracer the antigen transglutaminase conjugated to a colored substance, like colloidal gold or colored latex particles. The conjugated antigen is deposited onto an inert fibrous support, from where it can be released by a liquid sample. The antibodies in the sample react with the conjugated antigen developing an immunocomplex that migrates through a carrier membrane, like nitrocellulose or nylon with a pore size that allows a laminar flow of the reagents, until it reacts with the same antigen transglutaminase immobilized onto a reactive zone of the membrane. As a consequence of this reaction the immunocomplex will be trapped in the reaction site and a colored signal will be seen. Therefore a visually detectable signal in the reactive zone of the membrane indicates a positive result for the detection of anti transglutaminase antibodies in the sample.
Participants will receive a meal rich in high GI carbohydrates for dinner (day 5) first. After the wash-out day (day 6), the same meal will be provided for breakfast (day 7).
Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment in patients with abnormal uterine bleeding. Methods: In this multicenter retrospective cohort study of 287 patients with abnormal uterine bleeding, comprehensive clinical information and laboratory assessments, including cytokines, routine blood tests, and tumor markers, were performed. Associations between the clinical indicators and endometrial carcinogenesis/progression were evaluated. The independent risk factors for endometrial cancer and endometrial cancer with deep myometrial invasion were analyzed using multivariate binary logistic regression. Additionally, a diagnostic model was used to evaluate the predictive efficacy of these identified risk factors. Results: In patients with abnormal uterine bleeding, low IL-4 and high IL-8 levels were independent risk factors for endometrial cancer (p < 0.05). Combining IL-4, IL-8, CA125, and menopausal status improved the accuracy of assessing endometrial cancer risk. The area under curve of the model is 0.816. High IL-6 and IL-8 levels were independent risk factors for deep myometrial invasion in patients with endometrial cancer (p < 0.05). Similarly, combining IL-6, IL-8, and Monocyte counts enhanced the accuracy of assessing endometrial cancer risk with deep myometrial invasion. The area under curve of the model is 0.753. Conclusions: Cytokines such as IL-4, IL-8, and IL-6 can serve as markers for monitoring endometrial cancer and its progression in women with abnormal uterine bleeding.
A transdermal medicament delivery device in the form of a printed temporary tattoo (2) which conceals the fact that the wearer is taking a drug. The ornamental appearance actually provides an incentive for wear. The medicated tattoo (2) includes a section of cardstock base paper (70), a clear base (50) bearing an ink design on one side, the clear base being attached to the cardstock base paper (70) on the other side by a release base (60) that dissolves when wet to allow detachment of the base paper, and an adhesive layer (20) coated over the ink design on the clear base for adhesion to the skin. A medicament or drug (30) is incorporated into the adhesive layer for diffusion therefrom into the skin of the wearer, and the adhesive layer (20) has predetermined permeability characteristics to ensure effective transdermal delivery of the medicament (30). The process for making the transdermal tattoos includes lithographic printing and silk screen coating to create the necessary layers, inclusive of drug deposition on the control membrane. Th net result is less susceptible to being dislodged, thereby allowing more conventional low-strength skin adhesives to make intentional removal easy and painless. Moreover, the tattoo can provide an outward visual indication of the progress of delivery.
The invention belongs to the technical field of medicines, in particular to a Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide particle preparation. The particle preparation is prepared by adopting Fomitopsis officinalis (Vill. : Fr.) Bond. polysaccharide as an active component and assisting by other pharmaceutical adjuvant materials which comprise a slow-release material, a filling agent, a bonding agent, a lubricating agent, and the like. The particle preparation solves the problems of low utilization ratio of traditional Chinese medicine effective components of Fomitopsis officinalis (Vill. : Fr.) Bond. and poor curing effect, has the effects of warming the lung, reducing phlegm, alleviating asthma and cough, dispelling wind, eliminating dampness and swelling, invigorating the blood circulation, micturating, and the like, and can reinforce the physical strength, prolong the fatigue resistant and anoxia resistant time and strengthen the stress capability of the human body.
Heart Failure (HF) is the inability of the heart to pump efficiently and the heart cannot perform the necessary circulation of blood through the body. This can result in symptoms like shortness of breath at rest or with minimal activity. Advanced heart failure is one of the leading causes of hospitalization and deaths in the United States. This is a prospective randomized, double-blind, placebo-controlled parallel group, multicenter study of the effectiveness of Nesiritide administered as serial infusions in the outpatient setting. Patients enrolled in this study will receive nesiritide or placebo for up to 12 weeks. Patients will then be followed for an additional 12 weeks. During the the first 17 weeks of the study patients will have multiple laboratory tests, have their vital signs (blood pressure and heart rate) assessed, and complete quality of life questionnaires. During the last few weeks of the study patients will be contacted to inquire how they are doing. The study hypothesis is that compared to placebo plus standard care, Nesiritide plus standard will reduce time to death or first occurrence of hospitalization due to heart or kidney problems. Safety will be assessed through the collection of adverse events, clinical laboratory tests and vital signs at various time points throughout the study. The patients assigned to the nesiritide group will receive a single 2.0mcg/kg bolus (one time injection) followed by serial IV infusions (4 to 6 hours) at a standard flow rate of 0.010 mcg/kg/min once or twice per week for 12 weeks. The patients assigned to the placebo group will receive matching placebo.
PURPOSE:To obtain the titled preparation containing granulocyte colony stimulating factor and at least one high polymer. CONSTITUTION:A stable granulocyte stimulating factor (G-CSF)-containing preparation comprising 1pt.wt. G-CSF [e.g. human G-CSF having 19,000+ or -1,000 (by sodium dodecyl sulfate-polyacryl-amide gel electrophoresis), at least one isoelectric point of pI=5.5+ or -0.1, pI=5.8+ or -0.1 and pI=6.1+ or -0.1 and an amino acid sequence from N end to 21st having a group shown by the formula] and 1-20,000pts.wt. at least one high polymer (e.g. hydroxypropyl cellulose, polyethylene glycol having 300-6,000 molecular weight, etc.). The preparation can be used by various administration forms such as oral administraction and parenteral adnimistration such as many injections, etc. Adsorption on the wall of container can be prevented and consumption of expensive components can be hindered.
Detection of measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL) is an important prognostic marker. The most common CLL MRD method in current use is multiparameter flow cytometry, but availability is limited by the need for expert manual analysis. Automated analysis has the potential to expand access to CLL MRD testing. We evaluated the performance of an artificial intelligence (AI)-assisted multiparameter flow cytometry (MFC) workflow for CLL MRD. We randomly selected 113 CLL MRD FCS files and divided them into training and validation sets. The training set (n = 41) was gated by expert manual analysis and used to train the AI model. We then compared the validation set (n = 72) MRD results obtained by the AI-assisted analysis versus those by expert manual analysis using the Pearson correlation coefficient and Bland-Altman plot method. In the validation set, the AI-assisted analysis correctly categorized cases as MRD-negative versus MRD-positive in 96% of cases. When comparing the AI-assisted analysis versus the expert manual analysis, the Pearson r was 0.8650, mean bias was 0.2237 log10 units, and the 95% limit of agreement (LOA) was ±1.0282 log10 units. The AI-assisted analysis performed sub-optimally in atypical immunophenotype CLL and in cases lacking residual normal B cells. When excluding these outlier cases, the mean bias improved to 0.0680 log10 units and the 95% LOA to ±0.2926 log10 units. An automated AI-assisted workflow allows for the quantification of MRD in CLL with typical immunophenotype. Further work is required to improve performance in atypical immunophenotype CLL.
Six individual 1-hour videos will be shown to participants at the same time points as, and with equal duration to, the MAP-I intervention. These videos will be recorded presentations that have been modified for HCT recipients based upon similar SHE interventions delivered in prior studies. Similar to the intervention group, patients in the SHE group will also participate in group Zoom chat sessions with equal frequency and duration lead by a study research coordinator. These sessions will allow for general patient interaction to discuss sleep and any questions or comments they may have, as lead by the group facilitator.
Patients meeting the inclusion criteria and not having any of the exclusion criteria will be randomized 1:1 to one of two study arms - intravenous administration of blinded active drug, infliximab or vedolizumab at weeks 0, 2, 6 and 14. Infliximab will be administered at a dose 5mg/kg body weight, and vedolizumab at a dose of 300 mg (body mass \> 40 kg) and 10 mg/kg (body mass \< 40kg).
<P>PROBLEM TO BE SOLVED: To flexibly change an action change plan according to a degree of achievement, and thus, to improve and promote health conditions by continuous action change without losing motivation.  <P>SOLUTION: A probability classification model in consideration of probability dependence relation between nodes equivalent to each item (attribute) of health checkup-history taking result data is generated. Attribute values of each node of the probability classification model are temporarily changed to the direction of improvement, change of a classification class node when temporary change is performed is checked, N pieces of high-order improvement plans in order from the one in which probability of the classification class node is improved with the least improvement are generated as plan candidates. An improvement plan portfolio is generated by listing the plan candidates in order from the one which is easily improved. Generation of the improvement plan portfolio is executed again according to change of individual tastes, constraint data, etc., and an improvement plan portfolio after change is generated and presented.  <P>COPYRIGHT: (C)2009,JPO&INPIT
<P>PROBLEM TO BE SOLVED: To obtain a composition in the oral cavity having excellent prophylactic effects and inhibitory effects on mouth odor and high persistence of the effects.  <P>SOLUTION: This composition in the oral cavity affords combined effects on scavenging of the mouth odor with a plant of the family Labiatae or its extract and inhibition of metabolism of causative bacteria of the mouth odor with a seed of a plant of the genus Zanthoxylum of the family Rutaceae or its extract and has the high inhibitory effects on the mouth odor and excellent fast-acting properties and persistence. The composition is obtained by formulating the plant of the family Labiatae or its extract and (B) the seed of the Zanthoxylum piperitum or its extract. Furthermore, a prophylactic preparation for the mouth odor is prepared by formulating one or two or more species of a plant of Cola acuminata and Cola nitida A. Chev. of the family Sterculiaceae or its extract, menthol and its derivative, a sweetener and a perfume, which has an improved taste.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patients will firstly warm up for 5 minutes and begin training on the treadmill. There will be two weekly sessions, lasting 40 minutes, for 6 weeks, reaching a total of 12 sessions. The exercise intensity will vary from 60 to 90% of the maximum heart rate (HRmax) predicted by the percentage formula HR = HR rep + percentage (HRmax - HR rep), where HRmax = 220-age (years) and HR rep = HR obtained for five minutes of rest. Heart rate and level of subjective perception of the effort will be monitored during all sessions. Patients from this group will also be educated about their back pain by receiving a copy of The back Book.
BACKGROUND: Osteosarcoma is a common malignant tumor with a low survival rate after metastasis. Current treatments have not proven to effectively increase patient survival rates. Immunotherapy is a promising new treatment approach, however, immune target therapy has not shown satisfactory results. This study aims to provide new insights and evidence for the use of immunotherapy in osteosarcoma, based on a comprehensive analysis of gene expression data from databases.
METHODS: Gene expression and GSAV analysis were conducted on samples from patients with metastatic and non-metastatic osteosarcoma in the TARGET and GEO databases to identify relevant genes. These genes were further analyzed using GO, KEGG, GSVA, correlation analysis, and immune microenvironment scoring techniques. The tissue location of gene expression was confirmed through single-cell analysis. Validation of gene expression patterns was performed using polymerase chain reaction, western blot, and immunohistochemistry.
RESULTS: The study identified FUCA1 and NCKAP1L as significantly enriched in non-metastatic osteosarcoma, with higher expression associated with better patient survival rates. Gene function enrichment was primarily related to immune functions, with positive correlations to macrophage phagocytosis, antigen presentation, and macrophage polarization pathways. Analysis of the immune microenvironment revealed a positive correlation between gene expression and immune scores, with increased presence of macrophages, T cells, and B cells in the high expression group. Single-cell analysis and experimental results confirmed the enrichment of FUCA1 and NCKAP1L in macrophages.
CONCLUSION: The identification of FUCA1 and NCKAP1L as potential prognostic biomarkers suggests their potential for improving patient outcomes. Modulation of macrophages may offer a promising strategy for enhancing the immune microenvironment in osteosarcoma.
The accelerometer, Fitbit, will be worn continuously. Subjects will wear the Fitbit for two weeks (without feedback) to obtain baseline activity data. The control group will continue to wear the fitbit for the next 24 weeks without any feedback or activity counseling. Following the 26th week of the study, the subjects in the control group will complete the same program given to the experimental group in weeks 2 through 26.
This is a randomized (study medication assigned to participants by chance), double-blind (neither the researchers nor the participants know what treatment the participant is receiving), placebo-controlled (an inactive substance which contains no drug) that is compared in a clinical trial with a drug to test if the drug has a real effect), multicenter (when more than one hospital or study team work on a medical research study) study. Study will enroll participants with suicidal ideation who are assessed to be at imminent risk for suicide. The study will consist of a screening evaluation performed within 48 hours prior to the Day 1 intranasal dose immediately followed by a 25-day double-blind treatment phase (Day 1 to 25), and a 65 day follow-up phase (Day 26 to Day 90). The total study duration for each subject will be approximately 13 weeks. Participants' safety will be evaluated throughout the study. If you or a loved one are having thoughts of suicide, please seek immediate medical help. Go to the emergency room or call the National Suicide Prevention Lifeline at 1-800-273-8255.
Display systems and methods for displaying output of an electronic medical device. The present invention relates to a display system for displaying an output of an electronic medical device. The display unit is configured to receive the display signal and present a visual output based on the display signal. The display signal unit is designed to receive data relating to the electronic medical device, to assign the data to a visualization type, to dynamically determine a corresponding representation of the received data according to the visualization type currently to be represented, and to generate a display signal on the basis of the data and the respectively determined representation and to output the display signal to the display unit. The display signal monitoring unit is connected to the display unit and the display signal unit in a signaling manner and is designed to receive the display signal and to receive an output signal from the display unit, which output signal contains information about the visual output carried out. The display signal monitoring unit is configured to compare the display signal and the output signal with each other and to output a warning signal if the consistency between the visual output made and the visual output to be made is insufficient.
Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.
Subjects with DS-TB. HRZE tablets (Isoniazid 75mg plus rifampicin 150mg plus pyrazinamide 400mg plus ethambutol 275mg combination tablets) dosed once daily Days 1-56 per the Subject's weight as follows: 30-37kg: 2 tablets; 38-54kg: 3 tablets; 55-70kg: 4 tablets; 71kg and over: 5 tablets.
PURPOSE: To take a fibrinogen concentrate out of plasma by using a stage for warming the plasma to a conditioning temp. of -5 to -1 deg.C. CONSTITUTION: The plasma is cooled to a first temp. of -10 to -40 deg.C from a temp. above 0 deg.C and the resulted solid material is warmed to a temp. near the freezing point of water. Next, the treated plasma is physically separated into this solid material and the liquid-like main part, i.e., water content of the plasma. The warming action is executed stepwise from the first temp. to the conditioning temp. of -5 to -1 deg.C. The size of the solid material is thereafter reduced and such material reduced in the size is brought to such a temp. at which the main part i.e., the water content of the plasma turns to liquid and the dissolution of the fibrinogen in the fluid is lowered as far as possible. The fluid is thereafter separated from the fibrinogen concentrate.
BACKGROUND: tRNA-derived small RNAs (tsRNAs) are newly discovered non-coding RNA, which are generated from tRNAs and are reported to participate in several biological processes in diseases, especially cancer; however, the mechanism of tsRNA involvement in colorectal cancer (CRC) and 5-fluorouracil (5-FU) is still unclear.
METHODS: RNA sequencing was performed to identify differential expression of tsRNAs in CRC tissues. CCK8, colony formation, transwell assays, and tumor sphere assays were used to investigate the role of tsRNA-GlyGCC in 5-FU resistance in CRC. TargetScan and miRanda were used to identify the target genes of tsRNA-GlyGCC. Biotin pull-down, RNA pull-down, luciferase assay, ChIP, and western blotting were used to explore the underlying molecular mechanisms of action of tsRNA-GlyGCC. The MeRIP assay was used to investigate the N(7)-methylguanosine RNA modification of tsRNA-GlyGCC.
RESULTS: In this study, we uncovered the feature of tsRNAs in human CRC tissues and confirmed a specific 5' half tRNA, 5'tiRNA-Gly-GCC (tsRNA-GlyGCC), which is upregulated in CRC tissues and modulated by METTL1-mediated N(7)-methylguanosine tRNA modification. In vitro and in vivo experiments revealed the oncogenic role of tsRNA-GlyGCC in 5-FU drug resistance in CRC. Remarkably, our results showed that tsRNA-GlyGCC modulated the JAK1/STAT6 signaling pathway by targeting SPIB. Poly (β-amino esters) were synthesized to assist the delivery of 5-FU and tsRNA-GlyGCC inhibitor, which effectively inhibited tumor growth and enhanced CRC sensitive to 5-FU without obvious adverse effects in subcutaneous tumor.
CONCLUSIONS: Our study revealed a specific tsRNA-GlyGCC-engaged pathway in CRC progression. Targeting tsRNA-GlyGCC in combination with 5-FU may provide a promising nanotherapeutic strategy for the treatment of 5-FU-resistance CRC.
In a randomized, 9-week crossover trial, we will test the effects of dietary cholesterol in individuals without baseline cholesterol intake through two 4-week dietary intervention periods, using baked goods containing egg yolks or egg-free baked goods. During the no-egg phase participants will consume an egg-free product for four weeks. Each week participants will be given a week's worth of egg-free baked goods.
It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T cell) binding sites, can be modified to be less allergenic by modifying the IgE binding sites. The IgE binding sites can be converted to non-IgE binding sites by masking the site with a compound that prevents IgE binding or by altering as little as a single amino acid within the protein, most typically a hydrophobic residue towards the center of the IgE binding epitope, to eliminate IgE binding. The method allows the protein to be altered as minimally as possible, other than within the IgE-binding sites, while retaining the ability of the protein to activate T cells, and, in some embodiments by not significantly altering or decreasing IgG binding capacity. The examples use peanut allergens to demonstrate alteration of IgE binding sites. The critical amino acids within each of the IgE binding epitopes of the peanut protein that are important to immunoglobulin binding have been determined. Substitution of even a single amino acid within each of the epitopes led to loss of IgE binding. Although the epitopes shared no common amino acid sequence motif, the hydrophobic residues located in the center of the epitope appeared to be most critical to IgE binding.