anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Little is known about the trends of imported infectious diseases among travelers to non-endemic countries during the novel coronavirus disease 2019 (COVID-19) pandemic. This article aimed to describe those among travelers to Japan.
METHODS: This is a descriptive study based on national surveillance data. Imported infectious disease cases were defined as those with a reported overseas source of infection among 15 diseases pre-selected based on the probability and impact of importation. The number of notified cases from April 2016 to March 2021 were described by disease and time of diagnosis. The relative ratio and absolute difference in case counts-both by number and per arrival-were calculated by disease comparing those from the pandemic period (April 2020-March 2021) to the pre-pandemic period (April 2016-March 2020).
RESULTS: A total of 3,524 imported infectious disease cases were diagnosed during the study period, including 3,439 cases before and 85 cases during the pandemic. The proportionate distribution of diseases changed but notification counts of all 15 diseases decreased during the pandemic. Accounting for arrivals, however, seven diseases showed a two-fold or greater increase, with a notable absolute increase per million arrivals for amebiasis (60.1; 95% confidence interval [CI], 41.5-78.7), malaria (21.7; 95% CI, 10.5-33.0), and typhoid fever (9.3; 95% CI, 1.9-16.8).
CONCLUSION: The epidemiology of imported infectious diseases changed during the pandemic. While the number of imported infectious disease cases decreased, the number of cases per arrivals increased considerably both in relative and absolute terms for several diseases of public health and clinical importance.
PURPOSE: To produce a pharmaceutical preparation, comprising a salt of metoprolol coated with a water-insoluble polymeric film and a dihydropyridine dispersed in a nonionic solubilizer, capable of manifesting good absorption and prolonged actions and useful for treating cardiovascular diseases. CONSTITUTION: This pharmaceutical preparation is obtained by mixing small beads, containing a salt of metoprolol which is a β-adrenoreceptor antagonist (e.g. a succinate) and coated with a water-insoluble polymeric membrane and a dihydropyridine compound that is a poorly water-soluble calcium channel blocking agent (e.g. felodipine or nifedipine) dispersed in a nonionic solubilizer (e.g. a polyethoxylated caster oil or an oxyethylated glycerol) with a matrix capable of forming a swollen gel in contact with water (e.g. hydroxypropyl methyl cellulose).
PURPOSE:To provide an anti-inflammatory ointment for external use having improved transcutaneous absorbability, by dispersing a propylene glycol solution of hydrocrotisone butyrate propionate in an ointment base composed of a paraffinic hydrocarbon and a surface active agent in the presence of purified water. CONSTITUTION:The objective ointment composed of 0.01-0.5pt.wt. of hydrocortisone butyrate propionate, 2.0-10.0pts.wt. of propylene glycol and purified water (the purified water accounts for 0.1-5.0pts.wt.), 0.1-6.0pts.wt. of a surface active agent and 97.0-75.0pts.wt. of a paraffinic hydrocarbon, is prepared by (1) dissolving hydrocortisone butyrate propionate in propylene glycol under heating, (2) adding the solution to the molten mixture of a higher paraffinic hydrocarbon (fluid paraffin, white petrolatum, etc.) and a surface active agent, (3) stirring the mixture under heating, (4) adding purified water to the mixture, and (5) cooling the mixture under stirring.
Participants will receive one-session of fear extinction training tailored to the participant's specific fear. 15 minutes after fear extinction, participants will receive 8 minutes of Sham Low-Level Laser Therapy stimulation. The laser will be directed at two areas on the forehead: bilateral frontal points Fp1 and Fp2 (on the EEG electrode placement system). The procedure will consist of alternating between each of these points after each minute. However, each point will receive only a brief (5-second) treatment to the intended site on the forehead, followed by 55 seconds of no treatment, for each one-minute cycle, functioning as a placebo dose of the treatment.
A system for scoring automatic prior authorization requests is provided. The system may receive a request for automatic prior authorization from a medical provider, and in response may provide the medical provider with a plurality of questions. Once answers to the questions are received from the medical provider, the system may compute a score for the request that relates to the overall trustworthiness of the request. If the score satisfies a threshold, the request is flagged for further review. Otherwise, the request may be processed as a normal request. The score may be based on a variety of heuristics that indicate that a request may be fraudulent or constructed to gain an automatic prior authorization. The heuristics may consider information such as the speed at which the questions were answered, the particular answers given to one or more of the questions, and the request history of the medical provider.
PURPOSE:To obtain a hypotensor having excellent hypotensive action and useful for the remedy and prevention of hypertension, by using a specific compound and its salt as an active component. CONSTITUTION:The objective agent contains 4'-ethyl-2-methyl-3-piperidinopro piophenone of formula and its salt as an active component. The compound of formula can be administered as a hypotensor by parenteral means in the form of injection, suppository, external drug or instillation or by peroral means in the form of powder, granule, etc. The administration dose remarkably depends upon the extent of the symptom, age or the means of administration, i.e. oral or parenteral. Usually, it is administered at a daily dose of about 10-800mg, preferably about 50-500mg, more preferably 50-200mg in several divided doses.
The present invention relates to microalgal-based anti-cancer formulation for the treatment of breast cancer. The formulation comprises silver nanoparticles in combination with the crude extract of microalgae. The crude extract is derived from ethanol and water. The extract of ethanol and water in co-application with silver nanoparticles at the correct dosage, ratios and duration of treatment, are effective in providing anti-cancer effects and reduced side-effects on healthy cells. The microalgae is selected from the group consisting of Nannochloropsis oculata, Tetraselmis suecica and Chlorella sp. The formulation is natural and hence ecological and environment friendly. In another aspect, the formulation may be used as antibacterial/antimicrobial and/or antioxidant agent. (Figure 1)
Since the conventional Apgar score has its limitations in preterm or resuscitated infants, specifications of the individual items of the original Apgar score were suggested (Specified Apgar). The Specified-Apgar will slightly change the Apgars' perspective, but will not alter the number of its components. The advantage of the proposed definitions is the applicability in all infants, regardless of resuscitative efforts or gestational age. However, neither the conventional nor the Specified-Apgar score describes the condition of the infant. That problem has been taken up by the American Academy of pediatrics (AAP)and the American College of Obstetricians and Gynecologists (ACOG). They suggested to use an expanded Apgar Score reporting form (Expanded-Apgar)that accounts for concurrent resuscitative interventions. Whereas the Specified-Apgar score describes the condition of the infant, the Expanded-Apgar is a measure of interventions needed to achieve this condition. By combining both scores (Combined-Apgar) the postnatal condition is described in more detail than by a single score alone.

To validate the accuracy of these scores in a population of very preterm infants, the present prospective, observational, international multicenter study is planned. Until today there is no gold standard available to describe infant's conditions and interventions. For the evaluation of the scores it was therefore hypothesized that the Combined Apgar predicts poor outcome (defined as either death or any major morbidity) better than the Specified Apgar or Expanded Apgar alone. Prediction of poor outcome was used as a surrogate parameter to test the predictive value of the Combined-Apgar score in a clinical setting for preterm infants. In an attempt to determine how strong of an association there is between the Combined Apgar Score and neurologic impairment in early childhood, we are presently engaged in a long-term follow-up of all surviving infants at a corrected age of 24 months.
The purpose of this research study is to evaluate whether Exposure and Response Prevention Therapy (ERP) can help adults with obsessive-compulsive disorder (OCD) in China following a training of professionals and ongoing consultation.The treatment time for each participant is approximately 12 weeks. This includes the time between the referral and the beginning of treatment, the treatment sessions, and the 1-month follow-up time. Therapy sessions will take place twice per week for 15 sessions total and last about 90 minutes each. In addition to the therapy sessions, participants will have 3 separate assessments. These assessments will occur (1) right after they agree to participate in the study, (2) immediately after ERP ends, and (3) 1 month after ERP ends. The assessments will take about 1 ½ hours each.
INTRODUCTION: Cerebral vasospasms remain a strong predictor of poor outcome after aneurysmal SAH. The aim of this study was to describe the time course of relevant vasospasms after aneurysmal SAH and to determine the variables associated with early-onset or prolonged and recurrent vasospasms.
PATIENTS AND METHODS: We conducted a retrospective, single-center study of consecutive adult patients with aneurysmal SAH admitted between 2016 and 2022 at our tertiary stroke center. Relevant vasospasms, defined as vessel narrowing detected in DSA in combination with clinical deterioration or new perfusion deficit, were detected according to our in-house algorithm and eventually treated endovascularly. The primary endpoint was the diagnosis of relevant vasospasms. As secondary endpoints, the time from hemorrhage to the onset of vasospasms and the time from the first to the last endovascular intervention were measured.
RESULTS: Of 368 patients with aneurysmal SAH, 135 (41.0%) developed relevant vasospasms. The median time between ictus and detection of vasospasms was 8 days (IQR: 6-10). Patients with early-onset vasospasms were significantly younger (mean 52.7 ± 11.2 years vs 58.7 ± 11.5 years, p = 0.003) and presented more frequently vasospasm-related infarctions at discharge (58.8% vs 38.7%, p = 0.03). In 74 patients (54.8%), recurrent relevant vasospasms were observed despite endovascular treatment. Younger age and early onset were significantly associated with longer duration of relevant vasospasms (both p < 0.05).
DISCUSSION AND CONCLUSION: Younger age was associated with early-onset and longer duration of relevant vasospasms in this study. More frequent clinical and diagnostic follow-up should be considered in this subgroup of patients that are at risk for poor outcomes.
Post-operative infectious complications including urinary tract infection (UTI), systemic inflammatory response syndrome (SIRS), and sepsis are uncommon but potentially devastating complications after ureteroscopy. The clinical guidance from the American Urologic Association (AUA) and the European Association of Urology (EAU) is to provide treatment for symptomatic urinary tract infections however the management for asymptomatic patients with positive cultures or those patients who are otherwise at high risk of urinary tract colonization is unclear. As a result, there is significant practice variation in pre-operative prophylactic antibiotic prescription, even amongst fellowship trained endourologists, with some providers prescribing over ten days of pre-operative antibiotics while others offer none. This is a critical gap in our understanding of pre-operative prophylactic antibiotic utilization in a population of patients not only at higher risk of harboring multi-drug resistant (MDR) organisms but are also more susceptible to deleterious outcomes due to their frailty. Recent randomized trials have demonstrated that short courses of pre-operative antibiotics are no less protective than long courses in patients undergoing percutaneous nephrolithotomy (PCNL) for stone removal. Ureteroscopy is the most commonly performed stone surgery worldwide. Establishing an evidence-based approach for antibiotic prophylaxis in the ureteroscopic surgical patient population will be impactful for a large number of patients. The goal of this study is to implement a well-designed randomized clinical trial to establish the standardized antibiotic protocol necessary to minimize unnecessary antibiotic use which may otherwise lead to adverse reactions and proliferation of multi-drug resistant organisms.
Superior hypogastric plexus block(SHPB) for pain relief is routinely implemented in cesarean section operations at H.S.U Kocaeli Derince Education and Research Hospital. The implementation of this procedure depends on the clinical situation of the patient, the preference of the surgeon and the anesthesiologist, the course of the operation, and whether the patient wishes or not. Superior hypogastric plexus block is performed with 0.25 % bupivacaine 30 ml injected under peritoneum above promontorium.

This is a prospective case-control study. The sample consisted of 60 women having cesarean-section with general anesthesia at H.S.U Kocaeli Derince Education and Research Hospital divided into two groups: the first group having superior hypogastric plexus block for pain relief and the control group not having superior hypogastric plexus block. All participants signed an informed consent and the study was approved by the Ethics Committee of Kocaeli University ( KUGOKAEK 2017/270). The sample size was calculated with G Power 3.1 program. With ki-square Goodness-of-fit test α:0.05 ,power 95% ,effect size 0.5 total sample size was calculated 52, including 26 in case group and 26 in control group. Women having cesarean-section with spinal anesthesia, women with known bupivacaine allergy, women with anxiety-depression disorder, women with known fibromyalgia were not enrolled to the study. Age, BMI(body mass index), education status, VAS (visual analog scale) scores ,the amount of analgesic used and the hour of gas extraction and bowel movement will be recorded.
<P>PROBLEM TO BE SOLVED: To obtain a hair nourishing and growing agent excellent in a hair growth promotion action and a hair thickening action.  <P>SOLUTION: This agent contains a liquid obtained by pressing or extracting Hirami lemons (produced in Okinawa is lands). In the extraction, Sake (rice wine), or the like, is used. The agent has a hair nourishing and growing action and a hair conditioning action. Hirami lemons contain a polymethoxyflavonoid, which acts as a principal active ingredient effective for hair growth.  <P>COPYRIGHT: (C)2004,JPO
Humanitarian crises often require urgent medical care to people of concern. Such medical aid includes assessing and treating acute medical needs and ongoing chronic health conditions. Among the people of concern there are children, who are often the most vulnerable population in humanitarian contexts because they often lack the experience, independence, and cognitive and verbal skills to deal with the ordeals they are facing. These limitations might prevent identification and diagnosis of pain. The under-diagnosis and under-treated pain by health care providers might be also due to the perceived urgency of more acute or life-threatening medical needs with limited medical equipment and personnel, lack of awareness, or assessment tools in such contexts. Additionally, due to issues of anonymity and lack of formal guidelines, there is a severe lack of standardized registration of children's pain conditions in humanitarian crises. Finally, acute pain is also a predictor of post-traumatic stress disorder, a common outcome in such disasters. We call on health care providers to use standardized scales to assess children's pain intensity, frequency, and duration, and to treat it appropriately. These will not only reduce children's physical suffering but may also prevent subsequent risk of PTSD.
This was a prospective RCT. Patients qualified for inclusion in the study if they met the following criteria: undergoing unilateral primary THA; having the ability to understand the relevant treatment process; aged between 18 and 75 years; a body mass index (BMI) ≤ 40 kg/m2; hemoglobin ≥ 12g/dL; American Society of Anesthesiologists (ASA) physical status classification of I or II; and no ongoing infection or blood coagulation disorders. Those with a history of coronary artery disease, chronic obstructive pulmonary disease, arrhythmias, or untreated obstructive sleep apnea were excluded. Eligible individuals who gave informed consent were randomly assigned (1:1) to an inpatient THA group or an SDD THA group. SDD-THA was defined as admission, surgery, and discharge within 24 hours, whereas the inpatients stayed in hospital for more than one day. Randomization occurred at the individual level and was performed by an independent statistician, utilizing an automatic computer-generated table of random numbers. Preoperatively, patients undergoing SDD-THA and their families received information in the form of teaching booklets and a teaching class conducted by a bedside clinician, which included the protocol, matters needing attention, exercise training, and home-based rehabilitation. All operations were performed by the same surgical team through a posterolateral approach. Standardized general anesthesia was administered by low-dose bupivacaine, to allow early postoperative patient mobilization. Celebrex 400 mg PO was used as routine analgesia before surgery. Cefazolin (1.0 g) and Tranexamic Acid (0.4 g) were administered 30 min prior to skin incision. A uniform perioperative multimodal pain management protocol was established by cocktail periarticular injection before wound closure, which consisted of Flurbiprofen axetil (50 mg) and Ropivacaine (200 mg). Patients in both groups accepted the same postoperative protocols. To avoid venous thromboembolism (VTE), all participants were encouraged to perform ankle pumping and quadriceps-setting exercises immediately. Additionally, patients were encouraged to get out of bed and ambulate progressively with assistance under the guidance of the bedside clinician.
The sleep state of a sleeper is estimated with high accuracy based on the influence of the deep body temperature on sleep. The learning device (30) learns the sleep quality of the sleeper. A learning device (30) is provided with an acquisition unit (31), a learning unit (32), and a generation unit (33). An acquisition unit (31) acquires, as a state variable, a characteristic quantity relating to the body temperature of the deep part of the person or a characteristic quantity relating to the skin temperature of the person. The characteristic amount related to the deep body temperature is determined based on at least a first deep body temperature of the sleeper when the sleeper falls asleep. The characteristic quantity related to the skin temperature is determined based on at least a first skin temperature at which the sleeper falls asleep. A learning unit (32) learns the state variables and the sleep quality in association with each other. A generation unit (33) generates a learning model based on the learning result of the learning unit (32). The learning model outputs the sleep quality by using the feature quantity related to the core body temperature or the feature quantity related to the skin temperature of the sleeper as an input.
PROBLEM TO BE SOLVED: To obtain a drug which contains a specific naturally occurring herbal medicine or its extract of which safety is confirmed as an active ingredient, inhibits the growth of Helicobacter pylori and is effective for prevention and treatment of gastritis, gastric and duodenal ulcers and the like. SOLUTION: This preventive and treatment agent contains hop or its extract having the inhibitory action on the proliferation of Helicobacter pylori as an active ingredient. The hop can be used in the form of the whole plant, strobile, hop pellet, hop extract or isolated hop extract which are used in beer brewing. In addition, the hop extract is fractionated to the α-acid and/or β-acid fraction and they are further fractionated and concentrated and the products can be used. The daily dose of this medicine is about 1 2,000mg/adult, particularly 10-1,000mg/adult. This agent can be orally given as it is or may be added to beverage and food and daily ingested.
The investigators propose a double-blind controlled trial of 24 patients with Privigen® (Immune Globulin Intravenous (Human), 10% liquid treatment) with 3:1 randomization. Subjects with scleroderma will be given 2 g/kg/mo of Privigen® or placebo (Albuminar®-5) for 6 months. Scleroderma is generally a progressive disease, and while the skin does improve with time in some patients, others have progressive disease in spite of aggressive treatment. Also, spontaneous improvement in other organ systems is even less likely. Patients entered into the trial will have failed to respond to standard of care treatment over the past 4 months. Thus, the investigators feel that any actual improvement observed can be attributed to the IVIG treatment. Since this is a pilot study, future larger controlled trials will be necessary to clearly demonstrate the effectiveness, but the investigators are hoping that this study will give us signals that will guide the future clinical trial.
The present invention provides a cosmetic gel film suitable for use in the cosmetic field and the medical field. Essential components of the cosmetic gel film of the present invention are a carboxyl group-containing water-soluble polymer, a polyhydric alcohol and an acid. The carboxyl group-containing water-soluble polymer is preferably a carboxyl group-containing polysaccharide. Although the water content in the gel film is 30% by weight, the water content is preferably controlled to 10% by weight or less. The cosmetic gel film is obtained by drying an aqueous solution containing a carboxyl group-containing aqueous polymer, a polyhydric alcohol and an acid as essential components. In this case, the acid is added in an amount such that the pH of the aqueous solution is in the range of 2.0 to 4.5.