anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The prospective involvement of the Wnt/β-catenin signaling pathway in epilepsy, with the proposed therapeutic uses of its modulators, has been suggested; however, comprehensive knowledge in this regard is currently limited. Despite postulations about the pathway's significance and treatment potential, a systematic investigation is required to better understand its implications in chronic epilepsy. We investigated the role of key proteins like β-catenin, GSK-3β, and their modulators sulindac and 6-BIO, in Wnt/β-catenin pathway during chronic phase of temporal lobe epilepsy. We also evaluated the role of modulators in seizure score, seizure frequency and neurobehavioral parameters in temporal lobe epilepsy. We developed status epilepticus model using lithium-pilocarpine. The assessment of neurobehavioral parameters was done followed by histopathological examination and immunohistochemistry staining of hippocampus as well as RT-qPCR and western blotting to analyse gene and protein expression. In SE rats, seizure score and frequency were significantly high compared to control rats, with notable changes in neurobehavioral parameters and neuronal damage observed in hippocampus. Our study also revealed a substantial upregulation of the Wnt/β-catenin pathway in chronic epilepsy, as evidenced by gene and protein expression studies. Sulindac emerged as a potent modulator, reducing seizure score, frequency, neuronal damage, apoptosis, and downregulating the Wnt/β-catenin pathway when compared to 6-BIO. Our findings emphasize the potential of GSK-3β and β-catenin as promising drug targets for chronic temporal lobe epilepsy, offering valuable treatment options for chronic epilepsy. The promising outcomes with sulindac encourages further exploration in clinical trials to assess its therapeutic potential.
FIELD: cosmetology. SUBSTANCE: innovation deals with masking compositions to be applied upon skin. The composition of masking paste includes mineral substance - schungite which causes no irritating impact upon skin, at weight portion of 15-35% against total volume. At the same time, the absorbing capacity of masking paste in visible and close infrared diapasons of electromagnetic radiation should correspond to 80%, not less. The paste provides a masking effect of absorption in close infrared diapason along with no harm for human skin during application. EFFECT: higher efficiency.
At the intervention sites the research nurse will teach the Tobacco Tactics Intervention to nurses. For nurses, the Cessation Toolkit includes: 1) 1 CEU contact hour for training; 2) PowerPoint presentation on behavioral and pharmaceutical interventions; 3) pocket card "Helping Smokers Quit: A Guide for Clinicians" developed by U.S. Department of Health and Human Services, Public Health Service; 4) behavioral and pharmaceutical protocols; and 5) computerized template for nurse documentation. For patients, the Cessation Toolkit includes: 1) brochure; 2) videotape; 3); and 4) pharmaceuticals.
The participant is assigned to receive a flyer that includes a message emphasizing the involvement of academic researchers and a $20 incentive. Then the participant is assigned to be a message that emphasizes the public health benefits of answering the survey questions (i.e. cost-benefit frame).
Cathepsin C is a cysteine protease widely found in invertebrates and vertebrates, and has the important physiological role participating in proteolysis in vivo and activating various functional proteases in immune/inflammatory cells in the animals. In order to study the role of cathepsin C in the disease resistance of shrimp, we cloned cathepsin C gene (MjcathC) from Marsupenaeus japonicus, analyzed its expression patterns in various tissues, performed MjcathC-knockdown, and finally challenged experimental shrimps with Vibrio alginolyticus and WSSV. The results have shown the full length of MjcathC is 1782 bp, containing an open reading frame of 1350 bp encoding 449 amino acids. Homology analysis revealed that the predicted amino acid sequence of MjcathC shared respectively 88.42 %, 87.36 % and 87.58 % similarity with Penaeus monodon, Fenneropenaeus penicillatus and Litopenaeus vannamei. The expression levels of MjcathC in various tissues of healthy M. japonicus are the highest in the liver, followed by the gills and heart, and the lowest in the stomach. The expression levels of MjcathC were significantly up-regulated in all examined tissues of shrimp challenged with WSSV or V. alginolyticus. After knockdown-MjcathC using RNAi technology in M. japonicus, the expression levels of lectin and heat shock protein 70 in MjcathC-knockdown shrimp were significantly down-regulated, and the mortality of MjcathC-knockdown shrimp challenged by WSSV and V. alginolyticus significantly increased. Knockdown of the MjcathC reduced the resistance of M. japonicus to WSSV and V. alginolyticus. The above results have indicated that cathepsin C may play an important role in the antibacterial and antiviral innate immunity of M. japonicus.
Surgery can precipitate the development of both chronic pain and long-term opioid use. There is a need for strategies to augment perioperative pharmacotherapeutic management of pain with non-pharmacologic strategies to prevent long-term sequelae. Psychological interventions such as cognitive behavioral therapy (CBT) can effectively reduce distress and improve functioning among patients with chronic pain. While CBT has been used extensively in patients with established chronic pain, it has not been used as a preventive intervention targeting the transition from acute to chronic postsurgical pain. The Perioperative Pain Self-management (PePS) program has the potential to reduce the incidence of chronic post-surgical pain and long-term opioid use among Veterans. This study will: Examine the efficacy of PePS compared to standard care on 6-month pain (primary outcome), mood and functioning outcomes as well as time to post-surgical opioid and other analgesic use cessation.
the objective of the study is to determine the effects of tabata training versus plyometric training on range of motion of ap chagi, agility and vertical jump in taekwondo players. The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah Internatinal University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in group A \& B through sealed envelope method by Non-probability Convenient random sampling technique. Subjects in Group A will receive tabata training. Group B will receive plyometric training. The outcome measures will be assessed by goniometrer, quadrant jump test - agility and vertical jump test.

The data will be analyzed by SPSS, version 25. Statistical significance is P= 0.05.
Published data demonstrate equal efficacy and improved quality of life when platinum and a taxane were compared with platinum and 5-Fluorouracil \[31\]. Additionally, weekly cisplatin regimens (30-40 mg/m2) with radiotherapy appear to be equally efficacious and better tolerated than standard high-dose cisplatin (100 mg/ m2) regimens with radiation therapy for locally advanced SCCHN \[32\] The investigators will thus attempt to reduce toxicity from induction chemotherapy with the use of docetaxel/cisplatin (or carboplatin) (TP) in place of our previously used standard regimen of cisplatin and 5-fluorouracil (PF) and administer weekly cisplatin (or carboplatin) with radiation for those patients who are responders to induction therapy. Finally, Phase I/II testing of the small molecule inhibitor, AT-101, has recently been completed, and suggests activity in solid tumors when combined with cytotoxic agents. Since the investigators have achieved such high survival rates with our treatment selection approach in laryngeal cancer, our ultimate goal is to reduce the rate of salvage laryngectomy which should improve quality of life. The investigators hypothesize that specific inhibition of Bcl-2/Bcl-xL function can increase response rates to neoadjuvant chemotherapy and decrease the need for salvage laryngectomy. Hence, the investigators propose this study: the treatment of patients with advanced SCC of the larynx with one cycle of platinum plus docetaxel with AT-101, followed by chemoradiotherapy for those responding to this induction regimen and reserving total laryngectomy for those who are non-responders.
The stromal cells that support blood cell production within bone marrow are pre-adipocytes and functional interactions with marrow fat cells have long been suspected. Adiponectin was recently isolated as an adipocyte product and shown to have structural similarities to Clq as well as members of the TNF superfamily. It suppresses myeloid differentiation in short term bone marrow cultures and also inhibits macrophage functions. These observations raised the possibility that precursors of other blood cell lineages interact with fat cells in marrow via adiponectin. It has now been determined that the factor blocks B lymphopoiesis in Whitlock-Witte type bone marrow cultures, but not the production of myeloid cells in Dexter cultures. Several observations suggest that non-lymphoid cells represent the target of this new mediator, and the B lymphoid lineage is only indirectly influenced. Highly purified lymphocyte precursors in stromal cell-free, serum-free cultures were unaffected by adiponectin. Similarly, there was no influence on IL-7 responding pro-B cells in clonal assays. However, the cytokine dramatically inhibited adipogenesis in culture, suggesting that it may normally be a feedback inhibitor of this process. PCR analyses revealed that COX-2 is induced on exposure of cloned preadipocytes to adiponectin, resulting in prostaglandin release. This is critical to the inhibition of adipogenesis, because a COX-2 inhibitor, DUP-697 blocked the response of preadipocytes to adiponectin. Furthermore, fat cell formation in response to adiponectin was defective in mice with disruption of the COX-2 gene. In contrast, expression of TNF-α, TGF-β, interferons and a new interferon-like cytokine known as limitin are not up-regulated by adiponectin. These results also demonstrate that COX-2 inducers can be used to cause weight loss, and that COX-2 inhibitors will cause weight gain.
Singar is identified as a novel molecule whose expression is varied before and after the polarization of a nerve cell and which occurs in the tip of an elongating axon, called a growth corn, which is important for formation/elongation of an axon. Singar is expressed specifically in the brain and the expression amount of Singar is largely increased in an individual during a period where the formation of an axon is increased. It is observed that Singar is highly enriched in a growth corn at the tip of an axon. When the expression of Singar is inhibited in a nerve cell in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce the axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce/promote the formation or elongation of an axon in a nerve cell.
Perceptual training is a type of perceptual learning that initiates neural modifications during continuous repetitive task training, thereby increasing neural efficiency and improving the visual processing capabilities of the cerebral cortex. The perceptual training program simulates the receptive field structure of simple cells in the primary visual cortex (area V1) through Gabor cursors and lateral occlusion techniques to awaken visual cells during repetitive visual tasks. Gabor Patches are targeted stimuli that are widely used in the field of optic neurology to produce highly effective stimulation of the primary visual cortex. Lateral shading technology can effectively stimulate specific neurons. It can not only improve the interaction of neurons in the cerebral cortex in patients with amblyopia, but also stimulate the cooperation of neurons. This technology has also been proved to be effective in normal people. Therefore, on the basis of this theory, we plan to use perceptual learning to conduct repetitive visual stimulation for three months, and return to visit three times within three months. The main indicator is contrast sensitivity, and the efficacy of perceptual learning is evaluated by evaluating the improvement of contrast sensitivity. The study was designed as a self-controlled before-and-after trial. Volunteers were recruited from the outpatients of Zhongshan Ophthalmic Center's ophthalmic trauma clinic to participate in the study.
PURPOSE: To obtain the food such as a cut leaf-containing sushi or a sour agent or megrim medicine containing tartaric acid by using grape leaves or young bunches pinched on a top-pinching work as raw materials. CONSTITUTION: Grape leaves or young bunches pinched on a top-pinching work are used as food materials to prepare foods such as INARIZUSHI (flavored boiled rice wrapped up with fried bean curd) containing the cut leaves or rice balls containing the cut leaves. These foods can be wrapped with the grape leaves or dished on the grape leaves. Young sprouts or young leaves until the middle of May are suitable for the foods, and the young bunches pinched on the top pinching work can also be used for the foods. Grape leaves, etc. washed with salt-containing hot water and then squeezed are picked in shochu (a low- class distilled spirit) and stored. The crystalline substance deposited on the surfaces of the leaves is extracted. Thereby, tartaric acrid can be obtained in an amount of about 15g from 1kg of the grape leaves or in an amount of about 12g from 1kg of the pinched young bunches.
Dantrolene sodium is metabolized by the liver, and it is theoretically possible that its metabolism may be enhanced by drugs known to induce hepatic microsomal enzymes. However, neither phenobarbital nor diazepam appears to affect dantrolene sodium metabolism. Binding to plasma protein is not significantly altered by diazepam, diphenylhydantoin, or phenylbutazone. Binding to plasma proteins is reduced by warfarin and clofibrate and increased by tolbutamide.

Cardiovascular collapse in association with marked hyperkalemia has been reported in patients receiving dantrolene in combination with calcium channel blockers. It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis.

Administration of dantrolene may potentiate vecuronium-induced neuromuscular block.
The invention relates to the pharmaceutical field, and discloses an L-citrulline malate effervescent preparation and a preparation method thereof. The effervescent preparation comprises, by weight, 45-90 parts of L-citrulline malate, 5-50 parts of a sweetener, 1-5 parts of polyvinylpyrrolidone and 1-5 parts of sodium bicarbonate. The form of the effervescent preparation is an effervescent granule or an effervescent tablet. Compared with ordinary pharmaceutical effervescent granules or effervescent tablets, the effervescent preparation has the advantages of better stability, effective avoiding of the gas production, packaging swelling and other phenomena in the packaging without adding a drying agent, and lower degradation degree of active components in the storage process. The citrulline malate effervescent tablet can be used for treating various diseases, such as weakness induced by acute infection, chronic diseases and operations fatigue, chronic fatigue and excessive fatigue. The L-citrulline malate effervescent preparation can be frequently administrated to effectively relieve fatigue; and the preparation method is simple and is easy to carry out.
Totally 2000 mg of JBM-TC4 per day. 2 capsules of 500 mg JBM-TC4 plus 1 capsule of 500 mg PEG-400 per time, twice a day.
The LIAR-Trial is a single-center, single blind randomized controlled clinical trial comparing patients undergoing isolated AVR via J-shaped upper hemi-sternotomy (UHS) and conventional AVR through a full median sternotomy (FMS). To reduce potential confounding by differences in implanted valve prostheses, in both arms of the trail, the diseased native aortic valve is planned to be replaced with a rapid deployment stented aortic bioprosthesis (Edwards Intuity Elite Valve System®, Edwards Lifesciences Corporation), the preferred type of valve prosthesis for a limited access approach. Patients will be randomized 1:1 to both arms with 80 patients per arm. Patients who are unwilling or unable to participate in the randomized study will be treated via conventional median sternotomy with a sutured aortic valve prosthesis and participate in a prospective registry.

Primary outcome is cardiac-specific quality of life, measured by two domains of the Kansas City Cardiomyopathy Questionnaire (KCCQ), up to one year after surgery. Secondary outcomes include, but are not limited to: generic quality of life measured with the Short Form-36 (SF-36), postoperative pain, perioperative outcome (i.e. technical success rate, operating time) and postoperative outcome (i.e. 30 day and one-year mortality, complication rate, hospital length of stay, reoperation rate and readmission rate). Questionnaires are administered face to face or by telephone prior to surgery and at one, three, six and twelve months after surgery. In the prospective registry the quality of life questionnaires and all clinical data from the patients will be collected and analyzed the exact same way as the data from patients included and randomized in the trial.
The invention discloses a docusate sodium pellet and a preparation method thereof. The docusate sodium pellet of the invention comprises a drug-loaded pellet core, an isolation layer and a taste masking layer from inside to outside in sequence. The docusate sodium pellet comprises docusate sodium and pharmaceutically acceptable auxiliary materials. Wherein the filler accounts for 60 to 95 percent of the weight of the drug-loaded pill core; the weight percentage of the disintegrant in the drug-loaded pill core is 3-8 percent; optionally adding cosolvent and binder; the weight of the isolating layer coating is increased by 4 to 9 percent; the weight of the coating of the taste masking layer is increased by 7 to 15 percent. The invention adopts extrusion-spheronization pellet preparation and fluidized bed coating technology. The docusate sodium pellet has stable quality and uniform in-vitro dissolution; can effectively cover the bitter and astringent taste of docusate sodium and improve the compliance of taking medicine.
OBJECTIVE: The study investigated the association between FLG-AS1 and cervical cancer prognosis and the interaction mechanism between FLG-AS1 and miR-147b in order to identify potential therapeutic targets for cervical cancer.
METHODS: In this study, tissue samples and clinicopathological characteristics were obtained from 125 cervical cancer patients. FLG-AS1 expression levels in the samples were detected by polymerase chain reaction assay. CCK-8 and Transwell assays were used to evaluate FLG-AS1's impact on cervical cancer cell proliferation and metastasis. The mechanism of action of FLG-AS1 and miR-147b was probed by a dual luciferase reporter gene assay. The prognostic nature of FLG-AS1 in cervical cancer was explored by a series of statistical approaches.
RESULTS: In cervical cancer cells and tissues, FLG-AS1 expression is markedly downregulated. FLG-AS1 inhibits the activities of cervical cancer cells by negatively regulating miR-147b expression. Patients with cervical cancer have a poor prognosis when FLG-AS1 expression is low.
CONCLUSION: FLG-AS1 may be considered as a novel cervical cancer prognostic biomarker candidate, which affects cancer cell progression by negatively regulating miR-147b.
HAIC of 5-FU (500 mg/m2, Q4W) and cisplatin (15 mg/m2, Q4W) will be administered for up to 4 cycles to patients with locally advanced HCC. Subjects who achieved sustained SD or better based on the mRECIST criteria after 2nd cycle of HAIC will be enrolled to receive 1x10\^9 cells VAX-NK/HCC infusion.
A method and system for personalized blood flow modeling based on wearable sensor networks is disclosed. A personalized anatomical model of vessels of a patient is generated based on initial patient data. Continuous cardiovascular measurements of the patient are received from a wearable sensor network on the patient. A computational blood flow model for simulating blood flow in the patient-specific anatomical model of the vessels of the patient is personalized based on the continuous cardiovascular measurements from the wearable sensor network. Blood flow and pressure in the patient-specific anatomical model of the vessels of the patient are simulated using the personalized computational blood flow model. Hemodynamic measures of interest for the patient are computed based on the simulated blood flow and pressure.
<P>PROBLEM TO BE SOLVED: To provide a method for diagnosing multiple sclerosis using objectively assessed biomarker levels and a method for predicting the development of attacks in a patient suffering from multiple sclerosis.  <P>SOLUTION: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample. Disclosed is a method for diagnosing multiple sclerosis by comparing the levels of antibodies in a test sample from a subject to a control sample selected from the group consisting of one or more individuals who have multiple sclerosis symptoms and have a known multiple sclerosis status and one or more individuals who do not show multiple sclerosis symptoms. In one embodiment, the antibodies are anti-maltose IgM. In a specific embodiment, the levels of antibodies to a set of different glycans are measured by means of carbohydrate-chips.  <P>COPYRIGHT: (C)2010,JPO&INPIT
The Hessian fly (HF), Mayetiola destructor (Diptera: Cecidomyiidae), is one of the most devastating insect pests of cereals including wheat, barley, and rye. Although wheat is the preferred host for HF, this continuously evolving pest has been emerging as a threat to barley production. However, characterization and identification of genetic resistance to HF has not been conducted in barley. In the present study, we used a genome-wide association study (GWAS) to identify barley resistance loci to HF using a geographically diverse set of 234 barley accessions. The results showed that around 90% of barley lines were highly susceptible, indicating a significant vulnerability to HF in barley, and a total of 29 accessions were resistant, serving as potential resistance resources. GWAS with a mixed linear model revealed two marker-trait associations, both on chromosome 4H. The resistance loci and associated markers will facilitate barley improvement and development for breeders. In addition, our results are fundamental for genetic studies to understand the HF resistance mechanism in barley.
PROBLEM TO BE SOLVED: To obtain a liquid composition for oral cavity excellent in suppressing effects on the adhesion of microorganisms to tooth surfaces, capable of effectively preventing bacterial plaques from being formed and effective in the prophylaxis of diseases in oral cavity by making the composition include a hydroxyethyl cellulose/dimethylallylammonium salt graft copolymer. SOLUTION: This composition is obtained by including a hydroxyethyl cellulose/dimethylallylammonium salt graft copolymer, preferably hydroxyethyl cellulose dimethyldiazllylammonium chloride graft copolymer. The above copolymer is prepared by carrying out a radical graft copolymerization of a dimethyldiallylammonium salt with hydroxyethyl cellulose. In the above composition, the amount of the formulated copolymer is preferably 0.001-2.0 wt.%. It is necessary that a granular substance is not substantially contained in the above composition. A viscous agent, a surfactant, a buffer agent, etc., can be contained as other formulating ingredients therein.