anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To compare maternal vascular indices and hemodynamic parameters at 35-37 weeks' gestation in pregnancies complicated by delivery of a small-for-gestational-age (SGA) or growth-restricted (FGR) neonate.
METHODS: This was a prospective observational study of women with a singleton pregnancy attending for a routine hospital visit at 35 + 0 to 36 + 6 weeks' gestation. The visit included recording of maternal demographic characteristics, medical history, vascular indices and hemodynamic parameters, which were obtained using a non-invasive operator-independent device and included pulse-wave velocity, augmentation index, cardiac output, stroke volume, central systolic and diastolic blood pressure, total peripheral resistance and heart rate. Women with hypertensive disorders of pregnancy were excluded. SGA was diagnosed if birth weight was < 10th percentile. FGR was diagnosed if, in addition to birth weight < 10th percentile, at the 35-37-week scan, uterine artery or umbilical artery pulsatility index (PI) was > 95th percentile or fetal middle cerebral artery PI was < 5th percentile.
RESULTS: Among the 6413 women included in the study, there were 605 (9.4%) cases of SGA, 133 (2.1%) cases of FGR and 5675 (88.5%) cases that were unaffected by SGA or FGR. Women with SGA or FGR, compared to unaffected pregnancies, had increased peripheral vascular resistance and reduced cardiac output. Central systolic and diastolic blood pressure were increased in the FGR group compared with the unaffected group. Aortic stiffness, as assessed by pulse-wave velocity, and augmentation index did not differ between affected and unaffected pregnancies. In the FGR group, compared with the SGA group, central systolic and diastolic blood pressure were higher, whereas heart rate was lower.
CONCLUSIONS: SGA and FGR pregnancies exhibit deranged maternal hemodynamic responses compared with unaffected pregnancies. Pregnancies with FGR have higher central blood pressure compared to those with SGA, but it remains unclear whether these differences are driven by the size of the fetus or pathological fetal growth. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.
PROBLEM: A seizure is a challenging situation for children with epilepsy. Little is known regarding the experience of children who perceive in advance that they are about to have a seizure.
METHODS: From September 2020 to February 2021, we invited children with focal epilepsies aged 6-18 years to participate in a semi-structured interview.
RESULTS: Of 52 children with focal epilepsies, 22 (42 %) said they perceive in advance that they are about to experience a seizure [11 with self-limited epilepsy with centro-temporal spikes (SELECTs), 11 with other focal epilepsies]. All 22/22 (100 %) children described physical symptoms such as headache or a numb feeling in one half of the body. Of those children, 17/22 (77 %) stated they try to do something about the seizure. Those strategies were perceived as helpful by 0/11 (0 %) children with SELECTs and 9/11 (86 %) children with other focal epilepsies (p < 0.001). Of the children with SELECTs 5/11 (45 %), and of those with other focal epilepsies 9/11 (86 %) stated they would like to know in the morning if they are to experience a seizure that day (n.s.).
CONCLUSION: Children who perceive in advance that they are about to have a seizure are well able to describe their experience. Most children take measures to manage their seizures. Those measures were regarded as helpful by most children with other focal epilepsies, but by no child with SELECTs. Larger studies are necessary to determine the factors contributing to the child's perception as well as the nature of the support that they require.
The invention relates to a novel lipid kinase which is part of the PI3 Kinase family. PI3 Kinases catalyze the addition of phosphate to inositol generating inositol mono, di and triphosphate. Inositol phosphates have been implicated in regulating intracellular signaling cascades resulting in alternations in gene expression which, amongst other effects, can result in cytoskeletal remodeling and modulation of cellular motility. More particularly the invention relates to a novel human PI3 Kinase, p110Δ which interacts with p85, has a broad phosphinositide specificity and is sensitive to the same kinase inhibitors as PI3 Kinase p110A. However, in contrast to previously identified PI3 Kinases which show a ubiquitous pattern of expression, p110Δ is selectively expressed in leucocytes. Importantly, p110Δ shows enhanced expression in most melanomas tested and therefore may play a crucial role in regulating the metastatic property exhibited by melanomas. The identification of agents that enhance or reduce p110Δ activity may therefore prevent cancer metastatis.
To accomplish ganglionated plexi ablation, LA target sites were identified as the anatomic locations where vagal reflexes were evoked by transcatheter high-frequency stimulation (HFS). Rectangular electrical stimuli were delivered at a frequency of 20-50 Hz, output amplitude 15 V and pulse duration of 10 ms, for 5 sec (Stimulator B-53, Biotok Inc, Russia).
According to the periodization theory, the seasonal training process of soccer players is divided into four periods such as pre-season, early competition, late competition, and transition. In general, these periods aim to prepare soccer players for the competitive season, improve their fitness and physical performance, and reduce the risk of sports injuries. Therefore, the loading applied to soccer players during these camp periods are the key determinants of physical performance enhancement and the control of sports injury risks. In particular, the mid-season camp period loading is an important requirement to maintain the gains obtained in the pre-season training programs throughout the season. In this context, sports clubs prefer regions with different physical conditions (sea level, high altitude etc.) for the camp periods and allocate serious budgets for this periods.

Previous studies largely focused on effects of the pre-season camp period on psychological state and physical performance in soccer players. However, few studies in the current literature focused on the mid-season camp period. To the best of authors knowledge, sports injury anxiety and physical performance responses to the mid-season camp period loading in professional soccer players has not been very well discussed. Therefore the aim of this study is to investigate the effects of 3-week mid-season camp period loading on sports injury anxiety level and physical performances of professional male soccer players.
A method and system for managing customer service processes for individuals and populations. In a specific health care embodiment, a clinician creates a draft care plan for a patient using template metadata. This plan includes a list of specific services to be provided. It can be routed to members of an inter-disciplinary team for input. Once finalized, workflow processes are instantiated for each service. An optimized itinerary is created for patient encounters. A workflow automation server manages the execution of each process instance, invoking resources according to workflow metadata. Care plans and encounter itineraries are automatically translated to a patient-understandable form. Clinical practice and outcomes data are analyzed to identify opportunities for improvement of the metadata. The method and system allows for selection of a population of patients, analysis of population data to identify needed services, and initiation of population interventions through automated updates to individual care plans.
At the baseline visit (week 0), the subject will begin rivastigmine treatment at a dose of 0.75 mg bid. This dose will be continued for two weeks and then increased to 1.5 mg bid for an additional eight weeks. At the week 10 safety visit, the dose will be increased to 4.5 mg/day (3.0 mg and 1.5 mg) for an additional 10 weeks. If a subject is unable to tolerate a particular dose, the dose will be lowered to the previously tolerated dose, down to a minimum of 0.75 mg bid. If the subject is unable to tolerate the 0.75 mg bid dose he/she will be dismissed from the study.
All sulfonylurea drugs, including glyburide and metformin hydrochloride, are capable of producing severe hypoglycemia [see Adverse Reactions (6)]. Concomitant use of glyburide and metformin hydrochloride with other anti-diabetic medication can increase the risk of hypoglycemia. A lower dose of glyburide and metformin hydrochloride may be required to minimize the risk of hypoglycemia when combining it with other anti-diabetic medications.

  


Educate patients to recognize and manage hypoglycemia. When initiating and increasing glyburide and metformin hydrochloride in patients who may be predisposed to hypoglycemia (e.g., the elderly, patients with renal impairment, patients on other anti-diabetic medications) start with a lower dose. Debilitated or malnourished patients, and those with adrenal, pituitary, or hepatic impairment are particularly susceptible to the hypoglycemic action of anti-diabetic medications. Hypoglycemia is also more likely to occur when caloric intake is deficient, after severe or prolonged exercise, or when alcohol is ingested.

  


The patient’s ability to concentrate and react may be impaired as a result of hypoglycemia. Early warning symptoms of hypoglycemia may be different or less pronounced in patients with autonomic neuropathy, the elderly, and in patients who are taking beta-adrenergic blocking medications or other sympatholytic agents. These situations may result in severe hypoglycemia before the patient is aware of the hypoglycemia.

  


These impairments may present a risk in situations where these abilities are especially important, such as driving or operating other machinery. Severe hypoglycemia can lead to unconsciousness or convulsions and may result in temporary or permanent impairment of brain function or death.
The proposed project includes both the HFCWO and MIE and will capitalize on the specific goals of each therapy and address the problem as a whole rather than piece-meal. The HFCWO aims to mobilize the secretions to the pharynx to allow the patient to expel the secretions. However, many patients diagnosed with ALS are unable to expel the secretions due to atrophied expiratory muscles. The HFCWO device uses a small air compressor with a vest that wraps around the chest to induce airflows to pull secretions from the walls of the airways, thin the secretions and move them up the airways towards the larger airways and pharynx. The MIE, a noninvasive therapy, removes secretions in patients who have an ineffective cough because the peak cough flows are less than 270 L/min. This device applies a positive pressure to the airway and rapidly switches to a negative pressure applied to the airway. The rapid switch between the two types of pressure simulates a natural cough, thus assisting with expulsion of the secretions. Logically, the two mechanisms of action of these devices should work synergistically to produce effective airway clearance to keep the lungs clear, healthy and reduce the risk of infections from stagnant secretions. Respiratory infections are especially serious for patients with ALS because the patient is not able to recuperate from infections as quickly as a person without ALS. The objective is to determine if changing the use of existing respiratory therapy devices can improve the physical and psychosocial health and quality of life for patients diagnosed with ALS and caregivers.
PURPOSE:An immobilized vaccine useful for providing extremely efficiently a specific antibody having no danger of pathopoiesis at all by using affinity chromatography, obtained by immobilizing a vaccine having deactivated infectivity and retained antigenicity. CONSTITUTION:Plasma positive in human HBs antigen is heat-treated, for example, at 50-70 deg.C for 8-12hr, at 95-105 deg.C for 150-190sec, to give an HBs vaccine having deactivated infectivity and retained antigenicity. The HBs vaccine is linked to a carrier of a water-insoluble organic or inorganic high polymer having a group (e.g., carboxyl group, amino group) to be linked to vaccine or a carrier of a polysaccharide, etc. which is treated with cyanogen bromide to give bonding ability, so that the desired immobilized vaccine is obtained. The immobilized vaccine is brought into contact with human plasma and linked to HBs antibody. The linked antibody is cut and eluted, to give a gamma-globulin pharmaceutical preparation having concentrated specific HBs antibody.
The present disclosure provides an operating method of a dopamine transporter check system, which includes steps as follows. The scanned image is received from of the subject's brain from a scan machine, where the scanned image is a three-dimensional image. The scanned image is aligned to a standard brain space to obtain a normalized scanned image. The intensity normalization is performed on the normalized scanned image. The normalized scanned image after the intensity normalization is converted into a two-dimensional image. Plural image data are cut out from at least one region of interest in the two-dimensional image, the region of interest includes a left caudate, a left putamen, a right caudate and a right putamen. A dopamine neuron loss degree measurement and evaluation model based on the image data through a transfer learning.
PURPOSE: Antimicrobial misuse contributes to antimicrobial resistance in thoracic transplant (TTx) and mechanical circulatory support (MCS) recipients. This study uses a modified Delphi method to define the expected appropriate antimicrobial prescribing for the common clinical scenarios encountered in TTx and MCS recipients.
METHODS: An online questionnaire on managing 10 common infectious disease syndromes was submitted to a multidisciplinary Delphi panel of 25 experts from various disciplines. Consensus was predefined as 80% agreement for each question. Questions where consensus was not achieved were discussed during live virtual live sessions adapted by an independent process expert.
RESULTS: An online survey of 62 questions related to 10 infectious disease syndromes was submitted to the Delphi panel. In the first round of the online questionnaire, consensus on antimicrobial management was reached by 6.5% (4/62). In Round 2 online live discussion, the remaining 58 questions were discussed among the Delphi Panel members using a virtual meeting platform. Consensus was reached among 62% (36/58) of questions. Agreement was not reached regarding the antimicrobial management of the following six clinical syndromes: (1) Burkholderia cepacia pneumonia (duration of therapy); (2) Mycobacterium abscessus (intra-operative antimicrobials); (3) invasive aspergillosis (treatment of culture-negative but positive BAL galactomannan) (duration of therapy); (4) respiratory syncytial virus (duration of antiviral therapy); (5) left ventricular assist device deep infection (initial empirical antimicrobial coverage) and (6) CMV (duration of secondary prophylaxis).
CONCLUSION: This Delphi panel developed consensus-based recommendations for 10 infectious clinical syndromes seen in TTx and MCS recipients.
Enrolled alcoholic hepatitis patients would have MELD of 11-20; and have met inclusion and exclusion criteria. DUR-928 as a novel study treatment would be administered in patients with moderate alcoholic hepatitis (AH) as determined by the absence of suspected unexpected serious adverse reaction (SUSAR).
A device for skin grafting is disclosed. The device can include a hollow body having a negative pressure chamber that is coupled to an orifice plate configured for placement on skin at a donor site. The orifice plate can comprise a plurality of openings through which a plurality of skin blisters can be raised. The device can also include a cutter plate, an actuator, and at least one light source configured to heat the orifice plate with radiative energy and warm the skin to facilitate formation of the plurality of skin blisters through said openings. The cutter plate can comprise a hole array and be positioned in the hollow body above the orifice plate such that at least a portion of the plurality of skin blisters protrudes through the hole array in the cutter. The actuator actuates the cutter to harvest the plurality of skin blisters.
Sleep problems are common in children with autism spectrum disorder (ASD), with 40% to 80% prevalence. Common disorders include insomnia, parasomnias, and circadian rhythm sleep-wake disorders. These problems have a multifactorial etiology and can both exacerbate and be exacerbated by core ASD symptoms. Sleep problems also impact the health and quality of life of both patients and their caregivers. All children with autism should be regularly screened for sleep problems and evaluated for co-occurring medical contributors. Behavioral interventions with caregiver training remain first-line treatment for sleep disorders in both neurotypical and neurodiverse youth.
The present invention belongs to the field of minoxidil external preparation treating alopecia areata and calvities, particularly to a minoxidil solution and a preparing method of a liniment tablet thereof. Components of proportion are that every 1000 milliliters of minoxidil solutions contain 5 to 60 grams of minoxidil, 100 to 600 milliliters of 1, 2-propanediol, 200 to 600 milliliters of ethanol whose concentration is 95%, 1 to 5 grams of sodium thiosulfate, 0.1 to 1 gram of 4-butyl amine hydrochloride, and water as the rest. The preparing method comprises the following procedures that the 1, 2-propanediol and the ethanol whose concentration is 95% are taken and heated to 40 DEG C, the minoxidil is added and dissolved, the sodium thiosulfate and the 4-butyl amine hydrochloride are dissolved by adding water, two solutions are mixed, water is added to full quantity and the minoxidil solution is prepared. The minoxidil solution has the advantages of stable quality, better solvent volatility and small stimulation for skin. The minoxidil solution is filled in a liniment tablet bag, each liniment tablet contains 0.5 to 3.0 milliliters of minoxidil solutions, the liniment tablet is composed of water absorbing carriers whose surface area is 10 to 50 square centimeters, and the liniment tablet is packaged in the closed bag. The liniment table has the advantages of accurate dose, safety and effectiveness and convenient use.
The invention comprises pyrazolo-[2 : 3-a]-imidazolidines having the ring skeleton <FORM:0888703/IV (b)/1> or their tautomeric forms which are unsubstituted in all positions or substituted in the 2, 5- and/or 6-position by lower alkyl radicals and in addition to or instead of substitution in the 2, 5- and/or 6-position may be substituted in the 3-position by a halogen atom and which substituted or unsubstituted compounds may be substituted on the secondary nitrogen atom by a lower alkyl phenyl, lower alkyl or lower alkanoyl radical, their therapeutically useful acid addition salts and quaternary ammonium compounds, and the preparation thereof by intramolecularly condensing a 3-aminopyrazole containing in the 2- position a free hydroxyl group attached by way of a saturated carbon chain of 2 carbon atoms, and, if desired, introducing and/or converting substituents and/or, if desired, converting a resulting free base into an acid addition salt or a salt with a free base.  The term "lower" indicates that the group so described contains 1-7 carbon atoms.  Intramolecular condensation is carried out by means of a dehydrating agent such as a strong acid and when the starting materials contain hydrolysable substituents or free carboxyl groups, they may at the same time be hydrolysed and/or decarboxylated.  Ethyl ethoxymethylene-cyanacetate with hydrazine gives 2(b -hydroxymethyl)-3-amino-4-carbethoxy-pyrazole which, on hydrolysis, gives the free acid and the acid on heating gives 2(b -hydroxyethyl) - 3 - aminopyrazole.  Specification 854,632 is referred to.ALSO:Pharmaceutical compositions comprise pyrazolo[2 : 3-a]imidazolidines having the ring skeleton <FORM:0888703/VI/1> or their tautomeric forms which are substituted in all positions or substituted in the 2,5 and/or 6-positions by lower alkyl radicals and in addition to or instead of substitution in the aforesaid positions may be substituted in the 3-position by a halogen atom and which unsubstituted or substituted compounds may be substituted on the secondary nitrogen atom by a lower alkyl phenyl, lower alkyl or lower alkanoyl radical ("lower" indicates groups containing 1-7 carbon atoms) or therapeutically acceptable acid addition salts or quaternary ammonium compounds thereof and a pharmaceutical carrier. The compositions may be in forms suitable for enteral or parenteral administration such as tablets, dragees, solutions, suspensions or emulsions and may contain additional therapeutically valuable substances.  Acid addition salts are formed from inorganic or organic acids.  The preparations exhibit sedative and antipyretic properties and are effective against tumours and vaccinia virus.  Specification 854,632 is referred to.
The pregnant woman will be informed about the possibility of practicing Mindfetalness verbally, in a brochure and at a website. The practice is described as spending 15 minutes every day from gestational week 28 to get to know the fetal movement pattern. The fetus must be awake when she practice Mindfetalness and the woman is suggested to lay on her left side when she observe the fetal movements. In the brochure as well at the website the woman can write down something about the nature, frequency or strength of the fetal movements. If the woman experiences decreased frequency of fetal movements or weaker movements she is instructed to seek health-care without unnecessary delay.
Inflammation assumes a pivotal role in the aortic remodeling of aortic dissection (AD). Asiatic acid (AA), a triterpene compound, is recognized for its strong anti-inflammatory properties. Yet, its effects on β-aminopropionitrile (BAPN)-triggered AD have not been clearly established. The objective is to determine whether AA attenuates adverse aortic remodeling in BAPN-induced AD and clarify potential molecular mechanisms. In vitro studies, RAW264.7 cells pretreated with AA were challenged with lipopolysaccharide (LPS), and then the vascular smooth muscle cells (VSMCs)-macrophage coculture system was established to explore intercellular interactions. To induce AD, male C57BL/6J mice at three weeks of age were administered BAPN at a dosage of 1 g/kg/d for four weeks. To decipher the mechanism underlying the effects of AA, RNA sequencing analysis was conducted, with subsequent validation of these pathways through cellular experiments. AA exhibited significant suppression of M1 macrophage polarization. In the cell coculture system, AA facilitated the transformation of VSMCs into a contractile phenotype. In the mouse model of AD, AA strikingly prevented the BAPN-induced increases in inflammation cell infiltration and extracellular matrix degradation. Mechanistically, RNA sequencing analysis revealed a substantial upregulation of CX3CL1 expression in BAPN group but downregulation in AA-treated group. Additionally, it was observed that the upregulation of CX3CL1 negated the beneficial impact of AA on the polarization of macrophages and the phenotypic transformation of VSMCs. Crucially, our findings revealed that AA is capable of downregulating CX3CL1 expression, accomplishing this by obstructing the nuclear translocation of NF-κB p65. The findings indicate that AA holds promise as a prospective treatment for adverse aortic remodeling by suppressing the activity of NF-κB p65/CX3CL1 signaling pathway.
Either NR at 1000mg/day or placebo for one week, followed by a washout period of 2-3 weeks, then a crossover to placebo or NR at 1000mg/day for one additional week. The end point was analyzed at end of each treatment.