anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a prospective, comparative, randomized study. Women with pure stress urinary incontinence or mixed urinary incontinence with a predominant stress component who had chosen to proceed with a midurethral sling will be randomized to two groups. The study group will have the hydro-dissection performed with a diluted liposomal bupivacaine solution. The comparison group would have the hydro-dissection performed with a diluted bupivacaine HCL and Lidocaine solution. The postoperative pain will be compared between groups using a visual analog scale. The quality of recovery will be compared between the groups using the quality of recovery short form. Postoperative opioid consumption will be compared between the two groups.
This invention discloses the concept of incorporating a radioactive agent and various dyes to enhance lymphatic drainage, sentinel and lymph nodes. The use of a gamma emitting radionuclide such as Tc-99m allows the localization of the lymph node(s) that allows the surgeon to initially plan the surgical procedure. On the day of the study the radiopharmaceutical may need to be injected imaged and with the skin marked externally to assist the surgeon in locating the node during surgery. In order to facilitate the surgical probe a gamma detecting surgical probe can assist in providing the relative location of the node. This procedure has been found to be useful, however it has often been difficult utilizing this procedure to find all of the nodes. This invention would incorporate the use of a radioactive probe with a dye, the addition of the dye into the particles would allow the physician to more rapidly identify lymphatic channels, sentinel and other node(s) and allow them to be excised which would dramatically reduce the surgical time for the patient.
A hydrogel for use in oral care. The hydrogel is ion beam cross-linked, the hydrogel is adapted to be disposed in the oral cavity and may be adapted to provide a denture fixative or may be loaded with a whitening agent for use in whitening one or more teeth and disposed on or adjacent one or more teeth and the whitening agent is slow-released to whiten the one or more teeth. Other loading materials may include materials for treatment of alveolitis or malodor, inter alia. The present invention is a new hydrophilic oral and dental cohesive hydrogel sheet designed to securely grip and cushion prosthetic devices in the human mouth with the further ability to slow release antimicrobial or other orally desirable agents. Additionally, the invention also provides a method of making an orally cohesive device that: 1) is easily adapted and applied to a removable dental prosthesis; 2) bonds well to alveolar ridge / palatal mucosa and denture acrylic materials; and 3) releases cleanly, with no tacky or thixotropic residue when the prosthesis is removed. The cohesive hydrogel gel device is a hydrogel-forming polymer mixed with water, optionally surrounding an internal scrim, and uses an electron-beam energy source to cause cross-linking. The method does not need any chemical additive to affect the cross-linking. Furthermore the beam energy can be adjusted to optimize the cohesive properties of either side of the device, as well as to compensate for addition of orally active agents, if any are chosen. The hydrogel sheets are pre-cut to fit most sizes of maxillary and mandibular full denture prostheses, but can be easily trimmed with a scissors by the end user for the ideal custom fit of any full or partial denture, in either arch.
Patients undergo one port appectomy. Skin incision about 2cm size is made upon umbilicus and dissection is performed to make opening. Then, wound retractcor(Alexis) is iserted on opening site and wound is extended. Rubber glove built-in three 5mm trocars is applied over wound retractor. Pneumoperitoneum is achieved via trocar and appendectomy is performed. After appendectomy, wound is repaired.
Implementations described and claimed herein provide systems and methods for acquiring circulatory system information from one or more patients. In one implementation, a device for acquiring ultrasound-generated data includes a housing, an imaging mechanism, and an adjustment mechanism. The housing has an interfacing surface with an opening, and the imaging mechanism is positioned in the opening. The imaging mechanism is rotatable in a plane generally parallel to the interfacing surface and pivotal about an axis generally orthogonal to the interfacing surface. The adjustment mechanism is positioned within the housing and associated with the imaging mechanism to cause the imaging mechanism to rotate in the plane or pivot about the axis. The adjustment mechanism comprises an orientation adjuster having an orientation actuator and a direction adjuster having a direction actuator.
PURPOSE: To potentiate cancer therapy by administering an antitumor agent and additionally administering a medicinal agent selected from polyunsaturated fatty acids and prostaglandins, etc. CONSTITUTION: A cancer therapy is potentiated by administering an antitumor- effective amount of a medicinal agent selected from chemotherapeutic agents (e.g. alkylating agents, anthracyclines), antitumor hormone preparations (e.g. estrogen analogues), antitarget cell antibody (pref. radioactively labeled), external and internal irradiation, thermotherapy, biological response controlling substances and an anti-cellular antigen-specific antibody, and additionally administering a medicinal agent selected from polyunsaturated fatty acids (pref. 6-30C fatty acids having at least three unsaturated bonds), prostaglandins, prostacyclines, thromboxane, leukotriene, malonaldehyde and triene epoxides.
Each subject receives a multiple dose of a 3.5% 2-Deoxyglucose as nasal spray solution. The maximum daily dose is 56 mg/day if applied 4 times/day, over 7 days.
Participants will be asked to ingest 21 Dex4® tablets and no more than 300ml of water within 5 minutes. Blood draws will be performed at fasting (before ingesting the dextrose monohydrate tablets), as well as 1 hour after (+/- 15 minutes) and 2 hours (+/- 15 minutes) after ingesting the dextrose monohydrate tablets.
0.9% Sodium Chloride Injection USP is supplied sterile and nonpyrogenic in partial fill polyolefin containers. The 100/150 mL product is packaged 64 per case. The 50/100 mL product is packaged 84 per case. The 25/100 mL product is packaged 116 per case.

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended that the product be stored at room temperature (25°C); however, brief exposure up to 40°C does not adversely affect the product.
The use of iodinated contrast media in CT is associated with an immediate hypersensitivity reaction in a dose-dependent manner. Therefore, it is important to reduce the contrast dose for CT exams in patients who are required repeated CT examinations, including patients with hepatocellular carcinoma (HCC). Low monoenergetic images of dual-energy CT can provide higher iodine contrast than conventional images, thus enabling reduction of contrast media. The high image noise in low monoenergetic images may be improved by using model-based IR techniques and deep learning-based denoising (DLD) algorithms. Besides, lean body weight (LBW)-based contrast dose determination can be another option to reduce contrast media dose compared with total body weight-based dose determination since the volumes of blood and liver are not strictly proportional to total body weight. Therefore, we surmised that 50 keV images reconstructed with DLD algorithms with reducing iodine load by 30% based on LBW could produce the comparable image quality and lesion conspicuity compared with standard iodine-dose 120kVp images.

In this single-center prospective, randomized clinical trial, we aimed to investigate the effectiveness of low-contrast dose CT using 50 keV and DLD technique compared with the standard contrast-dose protocol using model-based IR in patients at high risk of HCC.
Protein aggregation is a hallmark of age-related neurodegeneration. Yet, aggregation during normal aging and in tissues other than the brain is poorly understood. Here, we leverage the African turquoise killifish to systematically profile protein aggregates in seven tissues of an aging vertebrate. Age-dependent aggregation is strikingly tissue specific and not simply driven by protein expression differences. Experimental interrogation in killifish and yeast, combined with machine learning, indicates that this specificity is linked to protein-autonomous biophysical features and tissue-selective alterations in protein quality control. Co-aggregation of protein quality control machinery during aging may further reduce proteostasis capacity, exacerbating aggregate burden. A segmental progeria model with accelerated aging in specific tissues exhibits selectively increased aggregation in these same tissues. Intriguingly, many age-related protein aggregates arise in wild-type proteins that, when mutated, drive human diseases. Our data chart a comprehensive landscape of protein aggregation during vertebrate aging and identify strong, tissue-specific associations with dysfunction and disease.
Ureteral stents have been widely used in many urological operations. The main purposes of placing ureteral stents include improvement of ureteral obstruction, protecting renal function and drainage of infection. Although there are several reports regarding the effectiveness of long-term ureteral stents for malignancy ureteral obstruction, ureteral stricture and urolithiasis, the experience is limited about the long-term ureteral stents made by Taiwan. Thus, The investigators will conduct this post-marketing survey to observe and investigate the changes of ureteral stents, e.g. hydronephrosis, infection and stone formation. Now this product has been approved by European Medical Device Administration. The investigators have to propose the 5-year post-market survey report. Though this observation study, The investigators can further understand the clinical safety and effectiveness of placing ureteral stents
BACKGROUND: Podocyte injury plays an important role in the occurrence and progression of diabetic kidney disease (DKD), which leads to albuminuria. Cytoskeletal remodeling is an early manifestation of podocyte injury in DKD. However, the underlying mechanism of cytoskeletal remodeling has not been clarified. Histone deacetylase sirtuin6 (Sirt6) has been found to play a key role in DKD progression, and the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) pathway directly regulates the cytoskeletal structure of podocytes. Whereas, the relationship between Sirt6, the PI3K/AKT pathway and DKD progression remains unclear.
METHODS: Renal injury of db/db mice was observed by PAS staining and transmission electron microscope. Expression of Sirt6 in the glomeruli of db/db mice was detected by immunofluorescence. UBCS039, a Sirt6 activator, was used to explore the renal effects of Sirt6 activation on diabetic mouse kidneys. We also downregulating Sirt6 expression in podocytes using the Sirt6 inhibitor, OSS_128167, and induced upregulation of Sirt6 using a recombinant plasmid, after which the effects of Sirt6 on high glucose (HG)-induced podocyte damage were assessed in vitro. Podocyte cytoskeletal structures were observed by phalloidin staining. The podocyte apoptotic rate was assessed by flow cytometry, and PI3K/AKT signaling activation was measured by Western blotting.
RESULTS: Db/db mice exhibited renal damage including elevated urine albumin-to-creatinine ratio (ACR), increased mesangial matrix, fused podocyte foot processes, and thickened glomerular basement membrane. The expression of Sirt6 and PI3K/AKT pathway components was decreased in db/db mice. UBCS039 increased the expressions of Sirt6 and PI3K/AKT pathway components and ameliorated renal damage in db/db mice. We also observed consistent Sirt6 expression was in HG-induced podocytes in vitro. Activation of the PI3K/AKT pathway via a Sirt6 recombinant plasmid ameliorated podocyte cytoskeletal remodeling and apoptosis in HG-treated immortalized human podocytes in vitro, whereas Sirt6 inhibition by OSS_128167 accelerated HG-induced podocyte damage in vitro.
CONCLUSIONS: Sirt6 protects podocytes against HG-induced cytoskeletal remodeling and apoptosis through activation of the PI3K/AKT signaling pathway. These findings provide evidence supporting the potential efficacy of Sirt6 activation as a promising therapeutic strategy for addressing podocyte injury in DKD.
Vitamin E softgel,100mg,Tid,orally, 96 weeks. All participants receive standardized recommendations for life-style modification (Diet modification, weight loss, exercise).
Beta-blocker or other sympathetic nervous system suppressants: When therapy with minoxidil is begun, the dosage of a beta-adrenergic receptor blocking drug should be the equivalent of 80 to 160 mg of propranolol per day in divided doses.

If beta-blockers are contraindicated, methyldopa (250 to 750 mg, b.i.d.) may be used instead. Methyldopa must be given for at least 24 hours before starting therapy with minoxidil because of the delay in the onset of methyldopa's action. Limited clinical experience indicates that clonidine may also be used to prevent tachycardia induced by minoxidil; the usual dosage is 0.1 to 0.2 mg twice daily.

Sympathetic nervous system suppressants may not completely prevent an increase in heart rate due to minoxidil but usually do prevent tachycardia. Typically, patients receiving a beta-blocker prior to initiation of therapy with minoxidil have a bradycardia and can be expected to have an increase in heart rate toward normal when minoxidil is added. When treatment with minoxidil and beta-blocker or other sympathetic nervous system suppressant are begun simultaneously, their opposing cardiac effects usually nullify each other, leading to little change in heart rate.
YES is a partnership between the University of Michigan School of Public Health, the Flint Community Schools and the Genesee County Intermediate School District. The study will include participants at eight high-need middle schools with 21st Century after school programs.

Researchers have consistently found that participation in out of school programs enhances adolescents' well being and sense of worth, involves them in positive behaviors and helps them avoid involvement in problem behaviors. Although key elements of successful after school programs have been proposed (e.g., adult mentorship), the processes through which youth positive outcomes are achieved have rarely been empirically examined. Empowerment theory provides a unique conceptual framework for developing programs to enhance positive youth development because it incorporates the notion that health promotion requires not only that youth develop specific skills and positive assets, but also that youth become motivated to actively apply these skills and knowledge to become agents of positive change for themselves and in their communities. Thus, programs based on empowerment theory focus on building positive assets, connecting youth with local resources and adult role models, and engaging youth in community service activities. Ecological theory complements empowerment theory because it focuses attention on the social contexts in which youth develop, interactions between these contexts, and the roles youth can play in these contexts (e.g., schools, communities). An intervention approach informed by these two theories should enhance positive youth development by engaging youth in relevant ecological settings where they can learn skills, practice those skills, and establish the social resources to effectively navigate the social contexts in which they find themselves and develop into healthy adults.
BACKGROUND: Cryoanalgesia is a tool being used by interventional radiology to treat chronic pain. Within a certain cold temperature range, peripheral nerve function is interrupted and recovers, without neuroma formation. Cryoanalgesia has most often been applied to the intercostal nerve. Cryoanalgesia has applications to peripheral nerve surgery, yet is poorly understood by reconstructive microsurgeons.
METHODS: Histopathology of nerve injury was reviewed to understand cold applied to peripheral nerve. Literature review was performed utilizing the PubMed and MEDLINE databases to identify comparative studies of the efficacy of intraoperative cryoanalgesia versus thoracic epidural anesthesia following thoracotomy. Data were analyzed using Fisher's exact and analysis of variance tests. A similar approach was used for pudendal cryoanalgesia.
RESULTS: Application of inclusion and exclusion criteria resulted in 16 comparative clinical studies of intercostal nerve for this review. For thoracotomy, nine studies compared cryoanalgesia with pharmaceutical analgesia, with seven demonstrating significant reduction in postoperative opioid use or postoperative acute pain scores. In these nine studies, there was no association between the number of nerves treated and the reduction in acute postoperative pain. One study compared cryoanalgesia with local anesthetic and demonstrated a significant reduction in acute pain with cryoanalgesia. Three studies compared cryoanalgesia with epidural analgesia and demonstrated no significant difference in postoperative pain or postoperative opioid use. Interventional radiology targets pudendal nerves using computed tomography imaging with positive outcomes for the patient with pain of pudendal nerve origin.
CONCLUSION: Cryoanalgesia is a term used for the treatment of peripheral nerve problems that would benefit from a proverbial reset of peripheral nerve function. It does not ablate the nerve. Intraoperative cryoanalgesia to intercostal nerves is a safe and effective means of postoperative analgesia following thoracotomy. For pudendal nerve injury, where an intrapelvic surgical approach may be difficult, cryoanalgesia may provide sufficient clinical relief, thereby preserving pudendal nerve function.
A breathing technique called Pursed Lipped Breathing (PLB) has been proven to be beneficial for patients with COPD. PLB can ease shortness of breath and reduce stress and anxiety. This study will develop a mindful PLB module to compliment an already developed home based pulmonary rehabilitation program. In this study, patients will be randomized to either a group that does the home based pulmonary rehabilitation with the mindful breathing module and health coaching or a group that does the home based pulmonary rehabilitation with health coaching without the mindful breathing module. Both groups will do the home based pulmonary rehabilitation for 12 weeks. In addition there are questionnaires and the wearing of an activity monitor when you sign up and at 3 and 6 months.
A composition, which in aqueous solution is useful for cleansing surfaces, e.g. metal, wood or concrete surfaces, human or animal bodies, or clothes, contaminated with radio-active materials, comprises a minor proportion of an alkali metal, ammonium or amine salt of an aliphatic polyamino polycarboxylic acid and a major proportion of the calcium complex of the same salt.  A minor proportion of a detergent such as soap or an alkali metal polyphosphate may be added to the mixtures.  Polyamino polycarboxylic acids specified are ethylene diamine tetra-acetic acid, trimethylene diamine tetra-acetic acid, cyclohexylene diamine tetra-acetic acid, propylene diamine tetra-acetic acid and diethylene triamine penta-acetic acid.  In an example a mixture comprises 80 per cent. of the disodium-calcium complex and 20 per cent. of the tetra-sodium salt of ethylene diamine tetra-acetic acid to which is added 10 per cent. (based on the total weight) of a sodium poly-phosphate.  The mixture may be used in 5 to 20 per cent. aqueous solution.
PURPOSE:To provide a peptic ulcer remedy having no toxicity and no adverse action by containing a polysaccharide-containing substance originated from natural Polyporus Confluens Fr. as an active ingredient. CONSTITUTION:The mycelia of Polyporus Confluences Fr. (FERM 10701), a kind of edible mushroom belonging to the genus Polyporus, are cultured by an usual culture method, washed with physiological saline and subsequently dried to provide the dry mycelia. The dry mycelia are charged in a cellulose tube membrane, dialyzed with a water stream, mixed with ethanol and subsequently allowed to stand for a suitable time, followed by centrifuging and lyophilizing the resultant precipitates to provide the objective agent comprising grayish white powder consisting mainly of a polysaccharide-containing substance. The peptic ulcer remedy has following properties; elementary analysis: C 41.15%, H 7.03%, N 2.47%; saccharide content (converted into glucose): 90%; protein content (Lowry method): 4.3%; coloring reaction: positive to phenol sulfuric acid and ninhydrin reaction; soluble in water and alkali, insoluble in organic solvents.
The study will include 23 WA state local health jurisdictions (LHJ). Each LHJ will be a randomized unit and a unit in which we will measure outcomes. (LHJs are governmental administrative units that usually correspond with a county.) Because this is a stepped-wedge randomized trial, the study will have two groups (intervention and control). However, each LHJ will be in both groups depending on the time period.
PROBLEM TO BE SOLVED: To obtain the subject composition excellent in hair dyeing power and fastness, good in touch of hair after dyeing and capable of preventing the sagging of a coating liquid at the time of application to the hair by formulating a branched type nonionic surfactant with an amphoteric surfactant and a specific lower alcohol. SOLUTION: This composition is obtained by formulating (A) a branched type nonionic surfactant (e.g. an octyldodecyl ether having 5-30 number of mol of added polyoxyethylene), (B) an ampohoteric surfactant (e.g. laurylhydroxysulfobetaine) and (C) a monohydric lower alcohol (e.g. ethanol or 1-propanol). In the above composition, the amounts of the ingredients are preferably 0.1-50 wt.% of the ingredient A, 1-30 wt.% of the ingredient B and 1-50 wt.% of the ingredient C. Furthermore, (D) 0.01-20 wt.% of a higher alcohol (e.g. lauryl alcohol or myristyl alcohol) is preferably contained therein.
PURPOSE: An adhesive patch containing a drug is provided to prevent detachment of adhesive patch at peripheral part and enhance convenience of use. CONSTITUTION: An adhesive patch comprises a support(10) and main part(13) of the adhesive patch containing the adhesive layer(11) formed on the surface of the support. The adhesive patch has a peripheral part(22) and central part(21). The adhesive layer has air gap at the peripheral part. The peripheral part has 2 to 100 air gaps in the ratio of air gap/mm^3. The thickness of the adhesive layer is thinner than the thickness of the central part of the adhesive layer. The support is laminate of porous material and resin film. The central part of the adhesive layer has 50um of thickness and contains drug.