anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely ophthalmology, and can be used for prevention of choroidal neovascularisation following cataract phacoemulsification. After sampling the patients to be involved in the offered therapy, the cataract phacoemulsification surgery follows by a standard technique. A flexible intraocular lens is implanted. After the intraocular lens implanted, lucentis is injected intravitreally. ^ EFFECT: method provides prevention of choroidal neovascularisation and thereby a macular oedema following the cataract phacoemulsification surgery in the patients with age-related macular dystrophy and confluent drusen of Bruch's membranes. ^ 1 ex
Dogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks post-splenectomy in dogs with splenic masses. This study included 12 dogs that had splenectomy. Seven dogs received no treatment (group A), and five were treated with clopidogrel (group B). Clopidogrel was loaded at 10 mg/kg on day 2 and continued at 2 mg/kg until day 14. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, thromboelastography (TEG) was performed on the same days. In group A, there was significant elevation of platelet counts on days 7 (p = 0.007) and 14 (p = 0.001) compared to day 0. In group B, the platelet counts were significantly elevated on day 7 (p = 0.032) but no significant difference was found on day 14 compared to day 0. Platelet counts on day 14 were significantly higher in group A than in group B (p = 0.03). The lower platelet counts were correlated with alterations in TEG parameters, and no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0. Our study suggests that clopidogrel may reduce post-operative thrombocytosis and hypercoagulability in dogs that undergo splenectomy for splenic masses.
BACKGROUND: The association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. The aim of the present study was to investigate the association between NAFLD and OA in the US adults.
METHODS: A cross-sectional study was performed on participants in the 2017-2018 National Health and Nutrition Examination Survey (NHANES) cycle. NAFLD was defined by the vibration-controlled transient elastography. The diagnosis of OA was based on self-reported data. Weighted multiple logistic regression models and stratified analyses were performed to explore the relationship and verify the stability of the conclusions. Sensitivity analysis using multiple imputation for missing data and propensity score matching (PSM) were performed.
RESULTS: In total, 2622 participants [Male: 1260 (47.8%)] were included in this study with a mean age of 48.1 years old (95% CI, 46.6-49.6 years old), containing 317 (12.8%) OA patients and 1140 NAFLD patients (41.5%). A logistic regression indicated a significant association between NAFLD and OA without adjustment [odds ratio (OR) = 2.05; 95% CI, 1.52-2.78]. The association remained stable after adjustment for covariates (OR = 1.72; 95% CI, 1.26-2.34). Sensitivity analysis of missing data with multiple interpolation and PSM found similar results. A significant and consistent association of NAFLD with OA was still observed in each subgroup stratified by age and metabolic syndrome (MetS). Stratified by sex, obesity, and sensitivity c-reactive protein (hs-CRP) category, a statistically significant association was only shown in females, those without obesity, and those without hyper hs-CRP. The results illustrated that the relationship between NAFLD and OA was stable in all subgroups and had no interaction.
CONCLUSIONS: NAFLD was positively correlated with OA. Given the current pandemic of NAFLD and OA, clinicians should screen for NAFLD in arthritis patients and intervene early.
PURPOSE: A fusion protein containing a fibronectin domain and an osteocalcin domain and a composition containing the fusion proteins are provided to enhance binding affinity to hydroxy apatite and to prevent or treat bone diseases. CONSTITUTION: A fusion protein contains a fibronectin domain and an osteocalcin domain having Arg-Gly-Asp(RGD) sequence. The fibronectin domain contains RGD sequence. The fusion protein binds to hydroxyapatite(HA) and promotes integrin-mediated cell adhesion. The osteocalcin domain contains 18-95 amino acids binding to HA. The fibronectin domain and osteocalcin domain have amino acid sequences of sequence numbers 1 and 2, respectively. A composition for regenerating bone or teeth contains the fusion protein.
NOVEL 1,4-THIAZINE DERIVATIVE     ABSTRACT OF THE DISCLOSURE    Disclosed is a novel 1,4-thiazine derivative represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof:                     . . . . .  I     wherein R1, R2 and R3 respectively represent a hydrogen atom or a lower alkyl group.  Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise  reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II:                        III                     II     wherein R1, R2 and R3 are as defined above, A represents a group   in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid.  Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.
The present invention is an apparatus and method for a low-cost dispenser designed to control access to substances, including prescribed drugs. When used in conjunction with a prescribed drug, the dispenser controls access to the prescribed drug so that the patient only has access to the prescribed amount of drug at the prescribed frequency and for the prescribed period. The dispenser incorporates a dispenser housing, a rotatable insert, an insert locking system, and a processing system. The insert is rotatable and has compartments that are accessible through a slot in the dispenser housing. Two time periods are set through the processing system and control the insert rotation. The first time period sets the frequency, and the second time period sets the total time over which the frequency may occur.
Quitting smoking is challenging and relapse is likely. Smokers may perceive temptation to smoke as threatening if they think it suggests that they are unable to meet the challenges of cessation. When individuals experience such a threat to their sense of self-identity (e.g., to their sense that they have integrity and/ or competence), they often respond defensively. Individuals have a tendency to react defensively to information that informs them that their behavior increases risk for a particular disease or negative health consequences. Self-affirmation a process through which individuals focus on their strengths and values can offset threats to the self and promote healthier behaviors, including smoking cessation. To the extent that relapse or difficulty quitting is perceived as a threat to self-identity, when individuals are presented with the opportunity to self-affirm they may perceive failure as less threatening, mitigating the motivation to downplay the importance of quitting. Preliminary evidence suggests that self-affirmation can be feasibly incorporated into an existing smoking cessation text message-based intervention, and may bolster cessation rates among users motivated to quit smoking. Here, we propose to extend that research by examining whether the addition of self-affirmation text messages to a smoking cessation app (Smoke Free United Kingdom (UK) promotes smoking cessation, compared to standard of care (i.e., existing app content only). Importantly, self-affirmation material will be incorporated into the current app and will not change the goals or nature of the original texting program. We predict that the individuals in the self-affirmation condition will be more likely to report being smoke-free at the 1-month and 3-month follow-ups.
Carcinogenicity studies were performed in mice and rats. Both studies were negative for carcinogenic findings at exposures up to 9 times the human exposure at the recommended daily dose based on AUC.

Pexidartinib was not mutagenic in an in vitro bacterial reverse mutation (AMES) assay or clastogenic in either an in vitro human peripheral blood lymphocyte chromosomal aberrations assay or in an in vivo mouse bone marrow micronucleus assay.

Based on nonclinical findings, TURALIO may impair male and female fertility. In a fertility study in which pexidartinib was administered orally to male and female rats, there were reductions in pregnancy, as well as increases in pre- and post-implantation loss with a corresponding reduction in viable embryos at 40 mg/kg (approximately 1.3 times the human exposure at the recommended dose). Males at this dose level displayed reductions in spermatogenic parameters and adverse effects on sperm concentration, production, motility, and morphology. Lower testicular and epididymal weights occurred in this study at doses of ≥10 mg/kg/day (approximately 0.3 times the human exposure at the recommended dose). This is consistent with findings in chronic toxicology studies of germ cell depletion of the testes and hypospermia and cellular debris in the epididymis in male reproductive tissues of both rats and dogs at respective doses as low as 20 and 30 mg/kg/day (approximately 0.6 and 0.1 times the human exposure at the recommended dose). In rats, these changes persisted following a 16-week recovery period at the 60 mg/kg/day dose level (approximately 1.5 times the human exposure at the recommended dose).

In female rats, necrosis of corpora lutea occurred at doses ≥0.5 mg/kg/day (approximately 0.01 times the human exposure at the recommended dose) with pigment deposition within the interstitium of the ovaries, an increased incidence of luteal cysts and incidence/severity of hemorrhage of corpora lutea, and a decreased incidence of retained antral follicles and decreased corpora lutea at 60 mg/kg (approximately 1.8 times the human exposure at the recommended dose). In female dogs there were decreased follicle numbers and moderate atrophy of the oviduct, uterus, and cervix at doses as low as 1 mg/kg (approximately 0.01 times the human exposure at the recommended dose).
Patients randomized to Arm B with received Standard of care (SOC) BSA based melphalan dosing at 140 or 200mg/m2 per treating physician on Day -2 and will not receive the siltuximab. The melphalan will be infused over 30 minutes. Six peripheral blood samples of 5 ml in lithium heparin tubes will be collected at 5, 15, 30, 40, 75, and 150 minutes after the end of the melphalan infusion for PK testing. The first four time points are +/- 2 min and the last two time points are +/- 5 minutes.
A dermatological composition comprising positively chargeable core-shell nano-elements composed of a water-insoluble biodegradable compound capable of stimulating collagen synthesis (CSSC) at their core and at least one fatty amine, or a part thereof, in their shell, the CSSC having a molecular weight of more than 0.6 kDa and, the core-shell nano-elements being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less. Methods for preparing the dermatological composition and uses thereof are also provided. Preferably, the collagen-synthesis compound is chosen from a biodegradable polymer, most preferably polycaprolactone (PCL) or coenzyme Q10. In some embodiments, the polar carrier is a glycol, a glycerol or water. Emulsifiers or surfactants may also be included in the compositions. The fatty amine may be chosen from oleyl amine, octyl amine, cetrimonium chloride (CTAC), N,N-Dimethyl-dodecylamine (DMDA), N,N.-Bis-(2-hydroxyethyl)C12-C18-alkylamine, most preferably oleyl amine.
A Support and Counseling Program Based on the Roy Adaptation Model and a training booklet were prepared for women diagnosed with MGS. During the study, 5 counseling sessions were held for 4 months (16 weeks).
These participants will download a study-specific smartphone app ("eTEST"), and receive home-based HIV test kits in the mail every 3 months. These kits will have been fit with sensors that enable remote detection of when the kit was opened. Qualified HIV test counselors (QHTC) will then follow up with these participants within 24 hours of receiving notification that the test has been opened to conduct routine counseling, offer referrals for other services, and connect those with reactive results with follow-up care.
Fear of childbirth is a common clinical problem among perinatal women and link to adverse health effects on mother's and offspring's well-being. Recently, reducing the childbirth fear becomes a highly important maternity care issues as a result of the fact that the birth rate has been declining rapidly as well as Cesarean rate increased steadily. However, the studies on fear of childbirth among perinatal population in Taiwan were limited. In this proposal the investigators plan to conduct a randomized controlled study examining the effects of mindfulness-based childbirth education. In the randomized controlled study, women will be recruited and randomized into the experiment group (receiving mindfulness-based childbirth education and traditional childbirth education),or will be allocated in the control group receiving traditional childbirth education. Intention-to-treat analysis as well as mixed regression modeling will be used to estimate the effectiveness of the interventions.
Adipose organ, historically known as specialized lipid-handling tissue serving as the long-term fat depot, is now appreciated as the largest endocrine organ composed of two main compartments, i.e., subcutaneous and visceral adipose tissue (AT), madding up white and beige/brown adipocytes. Adipose organ dysfunction manifested as maldistribution of the compartments, hypertrophic, hypoxic, inflamed, and insulin-resistant AT, contributes to the development of type 2 diabetes (T2D). Here, we highlight the role of nitric oxide (NO·) in AT (dys)function in relation to developing T2D. The key aspects determining lipid and glucose homeostasis in AT depend on the physiological levels of the NO· produced via endothelial NO· synthases (eNOS). In addition to decreased NO· bioavailability (via decreased expression/activity of eNOS or scavenging NO·), excessive NO· produced by inducible NOS (iNOS) in response to hypoxia and AT inflammation may be a critical interfering factor diverting NO· signaling to the formation of reactive oxygen and nitrogen species, resulting in AT and whole-body metabolic dysfunction. Pharmacological approaches boosting AT-NO· availability at physiological levels (by increasing NO· production and its stability), as well as suppression of iNOS-NO· synthesis, are potential candidates for developing NO·-based therapeutics in T2D.
PURPOSE:To obtain a hot water extract liquid of fruiting bodies of Hericium erinaceus Pers and cultured mycelia thereof as active ingredients. CONSTITUTION:0.5-5 pts.wt. alcohol is added to 1 pts.wt. hot water extract or the condensate of fruiting bodies or mycelia of Hericium erinaceus Pers being an edible mushroom and belonging to Hydnaceae of soft Basidiomycetes and a high polymer precipitate fraction is dried. The dried ingredient is added as an active ingredient to prepare an antiulcer agent. As the liquid culture medium, yeast extract, glucose, etc., is used. The agent has antiulcer activity stronger than that of lentinan or Krestin which is a commercially available mushroom anticancer agent.
Arrestin domain containing 2 and 3 (Arrdc2/3) are genes whose mRNA contents are decreased in young skeletal muscle following mechanical overload. Arrdc3 is linked to the regulation of signaling pathways in nonmuscle cells that could influence skeletal muscle size. Despite a similar amino acid sequence, Arrdc2 function remains undefined. The purpose of this study was to further explore the relationship of Arrdc2/Arrdc3 expression with changes in mechanical load in young and aged muscle and define the effect of Arrdc2/3 expression on C2C12 myotube diameter. In young and aged mice, mechanical load was decreased using hindlimb suspension whereas mechanical load was increased by reloading previously unloaded muscle or inducing high-force contractions. Arrdc2 and Arrdc3 mRNAs were overexpressed in C2C12 myotubes using adenoviruses. Myotube diameter was determined 48-h posttransfection, and RNA sequencing was performed on those samples. Arrdc2 and Arrdc3 mRNA content was higher in the unloaded muscle within 1 day of disuse and remained higher up through 10 days. The induction of Arrdc2 mRNA was more pronounced in aged muscle than young muscle in response to unloading. Reloading previously unloaded muscle of young and aged mice restored Arrdc2 and Arrdc3 levels to ambulatory levels. Increasing mechanical load beyond normal ambulatory levels lowered Arrdc2 mRNA, but not Arrdc3 mRNA, in young and aged muscle. Arrdc2 overexpression only was sufficient to lower myotube diameter in C2C12 cells in part by altering the transcriptome favoring muscle atrophy. These data are consistent with Arrdc2 contributing to disuse atrophy, particularly in aged muscle.NEW & NOTEWORTHY We establish Arrdc2 as a novel mechanosensitive gene highly induced in response to mechanical unloading, particularly in aged muscle. Arrdc2 induction in C2C12 myotubes is sufficient to produce thinner myotubes and a transcriptional landscape consistent with muscle atrophy and disuse.
The attention control group (WE), will include education about healthy lifestyle behaviors and peer support. The attention control groups will also have weekly sessions for eight weeks in groups of 11 to 13 midlife Black women. Outcome measures will include perceived general health, depressive symptoms, life's simple 7 (LS7) score, and number of unhealthy days. Data collections will occur at baseline, 8 weeks, and 12 weeks.
The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, compositions and formulations, including recombinant adeno-associated viruses (rAAV). The present disclosure presents cell culture mediums for use in producing adeno-associated viruses (AAV), such as AAV which comprise a polynucleotide encoding a payload. In certain embodiments, the cell culture medium comprises a hydrolysate mixture, L-glutamine, poloxamer 188 (e.g. 10% pluronic F- 68), a lipid emulsion, and a cholesterol mixture. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells (VPCs). In certain embodiments, the production process and system use Baculoviral Expression Vectors (BEVs) and/or Baculoviral Infected Insect Cells (BIICs) in the production of rAAVs.
PURPOSE: To advantageously obtain the partially novel title compd. from p-alkyl-benzoic acid through alkylation, bromination, hydrolysis, tetraaminopyrimidine addition and cyclization, dehydrogenation, diethylglutamation and hydrolysis processes.  
     CONSTITUTION: A reaction product of a compd. represented by formula 2 (wherein R 1  and R 2  are H or 1-8C alkyl) and alkyllithium is reacted with a compd. represented by formula 1 under an anhydrous condition in an inert soivent in the presence of an acid acceptor at temp. of below 0°C to obtain a compd. represented by formula 4 and this compd. is reacted with bromine while pH is held to about 7-8 to obtain a compd. represented by formula 3. Subsequently, this compd. is reacted with a compd. represented by formula 5 at a pH of about 3-5 at a temp. of about 35-75°C to obtain a compd. represented by formula 6 and this compd. is reacted with KI 3  to obtain a compd. represented by formula 7 and, further, this compd. is successively reacted with isobutylchloroformate and diethyl-Lglutamate hydrochloride at 0-5°C in the presence of an acid acceptor to obtain a compd. represented by formula (p) and this compd. is reacted with dilute aq. alkali to obtain a partially novel compd. represented by formula I useful for treating leukemia. 
     COPYRIGHT: (C)1991,JPO
The invention relates to traditional Chinese medicine powder for treating psoriasis and a preparation method. The medicine comprises 24 traditional Chinese medicines. The medicine is characterized by comprising the following components according to weight parts: 6-12 parts of prepared Qin turtle, 0.5-1.5 pats of bezoar, 15-30 parts of astragalus root, 10-20 parts of angelica, 15-30 parts of smilax glabra rhizoma, 5-15 parts of yellow-corktree bark, 6-15 parts of peony bark, 6-15 parts of broom cypress fruit, 6-15 parts of red peony root, 6-15 parts of safflower, 5-15 parts of cortex dictamni radicis, 6-18 parts of kuh-seng, 3-15 parts of prepared zaocys dhumnade, 8-18 parts of raw tuber fleeceflower, 8-18 parts of rehmannia root, 3-15 parts of radix sileris, 3-10 parts of prepared cicada slough, 3-9 parts of stir-fried sibirian button bur, 2-9 parts of licorice, 6-15 parts of redroot gromwell root, 3-8 parts of prepared centipede, 3-8 parts of prepared scorpio, 4-12 parts of honeysuckle and 6-15 parts of radix salviae miltiorrhizae. The preparation method of the medicine comprises the following steps: firstly, pulverizingthe 23 traditional Chinese medicines of the Qin turtle and the like, then mixing evenly with bezoar powder which is ground into superfine powder after sieving by a sieve of 80-100 meshes, weighing and packaging into bags. 8 grams of the medicine are contained in each bag, one bag is used each time, and the medicine is taken thrice in one day and is taken with water after meal. The invention has the functions of removing the blood poison, totifying the internal deficiency, nourishing the stomach, strengthening the spleen, calming the liver and regulating the flow of qi and especially has a unique curative effect for removing toxin in blood. The invention has good curative effect, no dietetic restraint, easy radical cure, no relapse and low treating expense, the effective rate is 96.5%, and the cure rate is 91.5%.