anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The incidence of multifetal gestations has increased dramatically over the past several decades. Multiple pregnancies are frequently complicated by maternal and fetal morbidities and mortalities. Data show that the incidence of morbidity and mortality correlate with fetal number. In the United Kingdom, the single embryo transfer policy has reduced the incidence of multifetal gestation. Also, in the United States the ASRM (American society of reproductive medicine) has revised the guidelines to optimize the number of transferred embryos during IVF. However in Egypt, transfer of 3 to 4 embryos is still practiced. The procedure of fetal reduction aims to decrease the occurrence of maternal and perinatal morbidities related to multifetal gestations. It can be carried out transvaginally or transabdominally under ultrasound guidance. It may be done by potassium chloride injection through needle injection, mere mechanical disruption by a needle, or by radiofrequency ablation. In this study multifetal pregnancy reduction will be carried out through transvaginal route, at an early gestational age (6 weeks - 9weeks + 6days), and compare the efficacy, complications and pregnancy outcome using mere mechanical disruption against potassium chloride injection.
Key gene mutations are essential for colorectal cancer (CRC) development; however, how the mutated tumor cells impact the surrounding normal cells to promote tumor progression has not been well defined. Here, we report that PIK3CA mutant tumor cells transmit oncogenic signals and result in malignant transformation of intestinal epithelial cells (IECs) via paracrine exosomal arachidonic acid (AA)-induced H3K4 trimethylation. Mechanistically, PIK3CA mutations sustain SGK3-FBW7-mediated stability of the cPLA2 protein, leading to the synthetic increase in AA, which is transported through exosome and accumulated in IECs. Transferred AA directly binds Menin and strengthens the interactions of Menin and MLL1/2 methyltransferase. Finally, the combination of VTP50469, an inhibitor of the Menin-MLL interaction, and alpelisib synergistically represses PDX tumors harboring PIK3CA mutations. Together, these findings unveil the metabolic link between PIK3CA mutant tumor cells and the IECs, highlighting AA as the potential target for the treatment of patients with CRC harboring PIK3CA mutations.
The invention relates to the technical field of ultrasonic couplants, in particular to an edible transesophageal ultrasonic couplant which comprises raw materials of Mentha haplocalyxBriq., Opuntia stricta, Lonicera japonicaThunb., Aloe vera (Haw.) Berg, Isatistinctoria, corn flour and wheat starch. Specifically, the preparation method is as follows. Firstly, extracting Mentha haplocalyxBriq., Opuntia stricta, Lonicera japonicaThunb., Aloe vera (Haw.) Berg with water to obtain leach liquor. Then wheat starch is modified by complex enzyme to obtain modified starch and the prepared modified starch, corn flour and Isatistinctoria are then lightly parched with slow fire. After grinding them into fine powder, it is mixed with leach liquor, refined and extracted to get gel preparation, namely, edible esophageal ultrasonic couplant. The raw materials selected by the invention are all edible, which are non-toxic and harmless to human bodies. Using the ultrasonic couplant provided by the invention can obtain clear ultrasonic imaging.
PURPOSE:To provide the cleansing cosmetic containing as a base material a solubilized composition comprising an anionic surfactant, a specific lipophilic nonionic surfactant, an oil component and water, not requiring double face- washing after used, and excellent 111 its touch, etc. CONSTITUTION:This cleansing cosmetic contains as a base agent a solubilized composition comprising an anionic surfactant, a lipophilic nonionic surfactant having an HLB value of <=10, an oil component (e.g. liquid paraffin, olive oil, squalane), and water. The lipophilic nonionic surfactant is preferably an N- acylglutamic acid ester of the formula (R1 is 7-21C alkyl or alkenyl; R2, R3 are sterol, 1-22C alkyl, 2-22C alkenyl; (m),(n) are 0-30). The anionic surfactant is preferably N-acylglutamic acid salt, N-acylmethyltaurine salt, etc. The cleansing cosmetic does not require double face washing after used, and is excellent in cleansing force, touch and storage stability in skin-wetted states.
The long term goal of our work is to implement real world CPR training strategies that match training locales with at-risk populations, maximize resuscitation skill retention, and promote willingness to act. To accomplish this, we will empower stakeholders at UPHS hospitals to develop local implementation approaches, using either UPHS volunteers or nursing staff as VSI proctors. These stakeholders will be studied as a research subset. The VSI proctors will use the AHAs CPR Anytime kit, and will work with family members of patients at high risk for a CA to learn lifesaving CPR skills. We will use a modified AHA CPR video using the new AHA recommendations for bystanders which suggests doing chest compression only CPR. Using the original AHA video and the modified chest compression only video, we will randomize family members of patients at high risk for CA to one of these groups. The VSI proctors will also be blinded to which video these subjects will be watching. We will follow up with the family members at 1 month, 3 months, 6 months and 12 months to see if they retained their CPR knowledge and skills and to see if they had been in a situation where their CPR skills were needed and assess whether they performed their skills or not. We will also measure the number of people with whom the subjects shared their CPR Anytime kits a quantity known as the multiplier effect to determine if they had shared the CPR Anytime kit with their family and friends, thereby increasing the possible number of lay persons trained in CPR and in turn able to perform bystander CPR if needed. We will also assess the perceptions and attitudes of the nurses and volunteers regarding this project.
PURPOSE:To obtain a new elastase inhibitor, having inhibiting actions on human neutrophilic elastases, containing a specific compound and useful as preventing and therapeutic agents for inflammations such as pulmonary emphysema or adult respiratory distress syndrome or degenerative diseases. CONSTITUTION:A compound expressed by formula I (R<1> is H, hydroxyl group, lower alkyl, etc. ; X is O or NR<3>) is reacted with an acyl chloride, etc., in the presence of a tertiary amine (e.g. triethylamine) in an inert organic solvent at a temperature within the range of -20 to +50 deg.C while controlling the reaction to provide a compound, etc., expressed by formula II (R<2> is an acyl, carbamoyl, etc.). The resultant compound expressed by formula II is then treated with a tertiary amine in an inert organic solvent to produce a compound expressed by formula III that is an intermediate, which is subsequently reacted with an olefinic derivative to afford the objective compound expressed by formula IV (R<a> to R<b> are each H, hydroxyl group, alkyl, etc.).
A medical system for providing a functional image comprises a light source unit, a reflected light image detection unit, a fluorescence image detection unit, an image processing unit, and an image output unit. The light source unit emits visible light and near-infrared excitation light. The reflected light image detection unit detects a reflected light image by the visible light. The fluorescence image detection unit detects a fluorescence image by the excitation light. The image processing unit extracts a dominant region in which the intensity of a visible ray wavelength of interest corresponding to a preset fluorescent material is greater than the intensity of a comparative visible ray wavelength from the reflected light image. The image output unit outputs an image transmitted from the image processing unit. According to such a configuration, it is possible to provide a complementary functional image in which distorted ICG position and distribution information is corrected by simultaneously detecting not only the near-infrared fluorescence of ICG but also the dark green color information of the ICG.
Coronaviridae viruses usually cause mild respiratory disease in humans, nevertheless, a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019, resulting in the ongoing 2019-2021 coronavirus pandemic. The present invention discloses the use of coated iron oxyhydroxide nanoparticles (IOHNPs) for use in the treatment and/or prevention of viral infections caused by Coronaviridae, especially those caused by respiratory syndrome-related coronaviruses such as SARS-CoV and SARS-CoV-2 and MERS-CoV. The iron oxyhydroxide nanoparticles are coated with biocompatible molecules and polymers which bind to the nanoparticle core via oxygen (e.g. sorbitol and sucrose). The IOHNPs were found stable, non-cytotoxic in vitro and can efficiently impair virus replication and transcription. Furthermore, the IOHNPs are suitable for oral, intranasal or parenteral administration in combination with a pharmaceutical carrier.
Hamstring injuries are most common injuries in sports and there are many treatment methods and rehabilitation protocols available which are used according to the extent of injury. The main purpose of this study was to check the effectiveness of two treatment techniques on the hamstring muscle flexibility in collegiate athletes. Muscle Energy Techniques (MET) and their related post-isometric relaxation and post facilitation stretching techniques have demonstrated better results in improving flexibility of the tightened muscles. The study was a randomized clinical trial at Pakistan sports board and coaching center Lahore in which convenience sampling technique was used. This study included total 48 participants and for this purpose Open Epi tool software was used as a sample size calculation. Participants falling in this category were recruited into the study, those were male athletes with ages 18 to 35 having bilateral hamstring muscle tightness and acute hamstring injuries. Participants failing to fall in this category were excluded of the study such as females and athletes with hip, buttock and low back pain radiating to back of thigh and history of fractures within 6 months. Universal goniometer, SLR, active knee extension test and sit to reach test would be used as a tool for pre and post assessment of athletes. In this study the subjects were assigned through convenience sampling into two groups. Group A was treated with post isometric relaxation technique and group B was treated with post facilitation technique. Data will analyze through SPSS version 25.0
In part A of the study patients will be treated with daratumumab as a single agent. In case patients have progressive disease after cycle 1, or in case patients achieve less than minimal response after cycle 2, or patients achieve less than PR after cycle 3, or in case patients experience progression during daratumumab therapy after having obtained a response, then ATRA will be added to daratumumab (part B).
PURPOSE: Total hip arthroplasty (THA) has demonstrated excellent results in elderly patients, however, the indications, outcomes, and long-term results in adolescent patients are less understood. This study aims to assess the outcomes of THA in patients under 21, providing insights for clinical decision-making in this exceptional population.
METHODS: A systematic review in PubMed, Ovid MEDLINE, and Embase database was performed. We included studies reporting clinical, radiological, and functional outcomes of THA in patients younger than 21 years, for any cause, with a with a minimum follow-up of one year. The ten year survivorship estimate was pooled using a meta-analysis methodology and each study was weighted according to its standard error, calculated from published confidence intervals.
RESULTS: We included 25 studies involving 1166 hips. Median age was 17 years old, 60% were females, and the average follow-up was 8.1 years. Juvenile inflammatory arthritis was the main indication for total hip arthroplasty (THA). The all-cause revision rate was 14.4% and aseptic loosening was the most common cause. Only eight studies reported ten year survival rates and form the pooled analysis an 84.91% survival rate (95% CI 70.56 - 99.27) was obtained. An average score of 88.08 in the Harris Hip Score (HHS) was observed. We found a 3.43% complication rate.
CONCLUSIONS: Hip arthroplasty is an acceptable option for adolescents with end-stage arthritis. However, the altered hip anatomy, the elevated revision rate, and the long-term implant survival must be considered before performing a THA in adolescent patients.
Infants with a diagnosis of CP OR at high risk of CP as per the international Clinical Practice Guideline for early diagnosis of CP. In order to develop prognostic curves for motor function a minimum of 3 data points are required per participant. For this reason infants will be included if they are 12 months or younger (corrected age) at the time of enrolment.
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols on mood and anxiety disorders at the National Institute of Mental Health (NIMH) and for the collection of natural history data. Subjects in this protocol will undergo an evaluation which may include: a psychiatric interview; a diagnostic interview; rating scales; a medical history; a physical exam; brain magnetic resonance imaging (MRI); computed tomography (CT); electroencephalography (EEG); electrocardiography (EKG), magnetoencephalography (MEG); blood, saliva and urine laboratory evaluation; and a request for medical records. The data collected may also be linked with data from other mood and anxiety disorder protocols (e.g., brain imaging, DNA, psychophysiology tests, treatment studies, etc) for the purposes of better understanding the diagnosis, pathophysiology, and treatment response of patients with mood disorders. Parents of minors will be interviewed. Upon conclusion of the screening process, subjects will either be offered participation in a research protocol and will sign the appropriate informed consent, or will be considered not appropriate for participation in research and will be referred back into the community. The current protocol thus serves as an entry point for individuals with mood or anxiety disorders or healthy volunteers to enter NIMH IRB approved protocols.
In mice and rats, large intravenous doses of meropenem (2200 mg/kg to 4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities. 

Intentional overdosing of Meropenem for injection (I.V.) is unlikely, although accidental overdosing might occur if large doses are given to patients with reduced renal function. The largest dose of meropenem administered in clinical trials has been 2 grams given intravenously every 8 hours. At this dosage, no adverse pharmacological effects or increased safety risks have been observed. 

Limited postmarketing experience indicates that if adverse events occur following overdosage, they are consistent with the adverse event profile described in the Adverse Reactions section and are generally mild in severity and resolve on withdrawal or dose reduction. Consider symptomatic treatments. In individuals with normal renal function, rapid renal elimination takes place. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis; however, no information is available on the use of hemodialysis to treat overdosage.
[Problem] To provide: an information processing system that makes it possible to accurately select a cosmetic and the like suitable for a subject; and others. [Solution] According to one aspect of the present invention, an information processing system is provided. This information processing system is provided with a control unit. The control unit is configured to execute each of the following steps. In an acquisition step, information related to an individual organism in a sample collected from tissue of a subject's body is acquired as first information. In a selection step, a cosmetic and/or a cosmetic component suitable for the subject is selected on the basis of at least the first information and predetermined reference information.
A composition and a method of making a whole blood substitute are disclosed. The claimed invention duplicates the two phase heterogeneous physico-chemical system of natural whole blood and accordingly, is capable of carrying out virtually all of the physiological functions of whole blood. Albumin dispersed in a solution composed of distilled water, sodium chloride and urea, and to which a surface active agent such as lecithin is subsequently added, constitutes the preferred method of preparing the two phase aqueous liquid system on which this invention is based. Other ingredients necessary to the manufacture of the claimed composition of matter include stroma free hemoglobin, an appropriate sterol, electrolytes and proteins. Emulsification of the two phase aqueous liquid system and the additives given immediately above completes the preparation of the claimed synthetic whole blood. The method of manufacture described in this disclosure also provides for the separation of the phases of the two phase aqueous liquid system. Separation of the coacervate phase from the external equilibrium phase may be carried out prior to the introduction of the additives referred to above. In the preferred procedure, separation takes place after emulsification has been completed. Introduction of the claimed synthetic whole blood into the circulation is accomplished through intravenous transfusion. When introduced into the circulation, the coacervate phase of this invention will serve the functions of normally occuring hematocrit.
There is no standard preoperative (neoadjuvant) chemoradiation (NCRT) regimen for resectable esophageal cancer, because most if all trials failed to show any survival advantage favoring pCRT when compared to surgery only. This failure had been related to the lack of power of some trials, as well as the ability of chemoradiation to potentiate post-operative morbidity (including mortality), and therefore hampering the accrual of its own survival benefit. Hopefully, meta-analyses showed that NCRT increases survival when compared to surgery only. However, in the clinical practice, this does not make easier the choice of the best NCRT treatment. It appeared that the radiation regimen that were used in each randomized trials were heterogeneous with respect with dose, fraction, length of treatment, fields, dosimetry planning, and quality control. This applies also to chemotherapy with respect with the kind of cytotoxics that were used (including number of drugs), as well as dosage, and the number of cycles, although most of the time cytotoxics were fluorouracil and cisplatin.

Dutch colleagues recently showed that NCRT with weekly carboplatin and paclitaxel increase survival, without increasing postoperative mortality. Of note, most tumors in this trial arose from the lower third of the esophagus and esogastric junction and these habitually correlate with less postoperative morbidity compared to upper third tumors. Moreover, the lung volume spared from radiation was greater in junctional tumors than in upper third cancers - a critical point in the development of radiation-induced pneumonitis and subsequent postoperative mortality. It is difficult to understand how this taxane-based chemotherapy is active, as it did not make better that fluorouracil-based regimen in non-operable patients, and as NCRT with taxanes makes radiation-induced pneumonitis more likely. The favorable impact of this NCRT may lie on its radiation regimen. A moderate total dose of radiation, smaller radial margins than in other trials and modern dosimetry with 3D-planning all improve the safety of treatment and of subsequent surgery. Finally, the favorable impact of the Dutch NCRT regimen may lies on the fact that it does not include cisplatin, a compound which has been found related to the occurrence of more sudden deaths than a non cisplatin-based regimen such as the FOLFOX combination (fluorouracil, oxaliplatin, folinic acid) in the setting of definitive chemoradiotherapy.

Our aim is to evaluate the short-term benefit (complete resection rate) and safety (severe postoperative rate) of 2 preoperative regimen, (carboplatin-paclitaxel or fluorouracil-oxaliplatin-folinic acid), combined to the Dutch radiation backbone, in operable esophageal and junctional (Siewert I-II) cancer. The present trial offers the unique opportunity to compare two therapeutic strategies that have already been shown to be efficient in large randomized controlled trials offering level-1 evidence.
The present invention provides a compound suitable for treating cancer, in particular NSCLC, which exceptionally inhibits activity of oncogenic ROS1 kinase and ALK kinase. Further, the invention provides a composition, in particular a pharmaceutical composition, comprising said compound. Further, a method for targeting cancer cells harboring an abnormality in ROS1 gene or ALK gene by contacting a cell with said compound is provided. The compound of the invention has certain structural components such as a quinoline moiety in the backbone and at least one phenyl-containing moiety in a side chain with a hydrophobic substituent attached to the backbone via an up to 6-membered linking group as well as a further hydrophobic moiety. The presence of said structural components allows for an advantageous interaction with the ROS1 kinase domain and, further, with the ALK kinase domain. Hence, said compound represents a highly promising opportunity for patients bearing ROS1 - or ALK-dependent cancer. Concentration (pLM) Fig. 1A S .0 15 20 2:5 Concentration (pM) Fig. 1B
The Weaving Healthy Families curriculum is a cognitive-behavioral, support group model for high-risk families related to alcohol, tobacco, or other drugs (ATOD) and/or or domestic violence, child abuse, or neglect. This curriculum is tailored for all ages (i.e., (a) parents/caregivers; (b) early childhood (5-7); (c) children (8-11); and (d) adolescent (12-17) and is aimed at reducing alcohol and other drug (AOD) abuse, promote unity, address mental health problems, strengthen parenting skills, and bolster wellness and resilience.
Following intravenous injection, radioiodinated albumin human is uniformly distributed throughout the intravascular pool within 10 minutes; extravascular distribution takes place more slowly. Iodinated I 131 albumin also can be detected in the lymph and in certain body tissues within 10 minutes after injection, but maximum distribution of radioactivity throughout the extravascular space does not occur until two to four days after administration. The time at which extravascular activity is maximal has been designated as the “equilibrium time.” When this point has been reached, the radioactivity remaining in the intravascular and extravascular spaces decreases slowly and exponentially in parallel fashion.

The administered radioactivity is eliminated almost entirely in the urine, only about 2 percent of the total dose ultimately appearing in the feces.

The biologic half-life of iodinated I 131 albumin is dependent upon a number of factors, and published studies have varied considerably in their reporting of this figure. It has ranged, in the literature, from below 10 days to over 20 days. One important factor affecting the biologic half-life is the initial rate of excretion, and this depends in part on the quality of the iodinated I 131 albumin. With Volumex, the biologic half-life in normal individuals has been reported to be approximately 14 days.