anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Postoperative pneumonia is the most common complication in patients after lung resection for non-small cell lung cancer (NSCLC). The tolerable incidence of this complication ranges from 5 to 8 %. The aim of this study was to evaluate the influence of initial risk factors on the incidence of postoperative pneumonia in patients undergoing lung resection for NSCLC. A retrospective cohort study was conducted at the University Hospital Ostrava between January 1, 2016, and December 31, 2022. All adult patients who underwent pulmonary lobectomy for primary NSCLC during the study period were included in the study. A total of 350 patients were included in the study. The incidence of postoperative pneumonia was 10.9%. Analysis of baseline risk factors did not show a statistically significant association with the incidence of this complication. The only statistically significant finding was a longer hospital stay in patients with postoperative pneumonia. The risk of postoperative pneumonia in patients undergoing lung resection for non-small cell lung cancer cannot be clearly explained by the initial risk factors examined alone. The complex nature of this risk also requires a comprehensive approach to prevention, including both patient-centred measures and improved postoperative care.
PROBLEM TO BE SOLVED: To prevent the correspondence inputting mistake of the examinee of picture data and the calling mistake of picture data by a doctor by calling picture data from a storing device by identification data identifying the examinee and displaying it. SOLUTION: The examinee moves to a place where a picture system measuring instrument GZ by carrying with a portable storing medium CD and delivers the medium CD to the engineer to the instrument GD. After then, the engineer measures the examinee by the instrument GZ, which adds identification data to picture data and retains data in a storing device SV2. The engineer returns the medium CD to the examinee. Then the examinee delivers the medium CD to the doctor, who makes a display SV1 to read identification data in the medium CD. The display SV1 calls corresponding picture data from the device SV2 by identification data and displays it.
Recent epidemiologic studies have shown that women are at substantially greater risk for many clinical pain conditions, and there is a suggestion that postoperative and procedural pain may be more severe among women then men. During pregnancy, women experience an elevation in the threshold to pain and discomfort. In addition to hormonal changes, the changes in pain perception during pregnancy may be related to an increase in endogenous opioids.

Pain is the most feared experience in the intra and postpartum period, and severe pain experienced during this time can lead to significant morbidity, including chronic pain and depression. Much attention has been paid to tests that can predict patients at higher risk for pain. Temporal summation (TS) has been shown to be a simple and reliable test. Temporal summation represents the physiological wind-up phenomenon taking place at the spinal level of the central pain pathways. TS extent can be measured in humans by administering a series of noxious stimuli of constant intensity and of various modalities in order to evoke an increase in perceived pain. It is a very simple and easy test to perform, and very well tolerated by patients. Whether TS changes in pregnancy and whether TS in pregnancy correlates with pain perception during acute stimuli such as venipuncture is unknown.
Patient Information about   
COSOPT® (dorzolamide hydrochloride–timolol maleate ophthalmic solution)   
COSOPT (pronounced “CO-sopt”)

Read this information before you start using COSOPT and each time you refill your prescription. This is in case any information has changed. This leaflet provides a summary of certain information about COSOPT. Your doctor or pharmacist can give you more complete information about COSOPT. This leaflet does not take the place of careful discussions with your doctor. You and your doctor should discuss COSOPT when you start using your medicine and at regular checkups. Only your doctor can prescribe COSOPT for you.
MRI is a clinical routine test for imaging (creating a picture) of the structure and function of human organs using a giant magnet and other electronic and computing equipment. Functional MRI (fMRI) is an MRI that is done while the subject performs some simple activity or in resting state. It shows the areas of the brain that are activated by performing each of these activities or correlated with spontaneous brain activities (e.g. interictal spikes).

The EEG-fMRI session will be conducted at the University of Minnesota Center for Magnetic Resonance Research. If a subject has any metal implant in his/her body, s/he must not participate in the MRI test. After subjects pass through the routine screening for participation in the MRI test, an EEG cap with 64 electrodes will be put on his/her scalp and electrically conducting gels will be applied to each of these electrodes. One more electrode will be put on his/her back to record electrocardiographic signal. The electrodes location will be recorded by means of a device which can tell the positions of the electrode sensors. The EEG preparation procedure will take around 30-45 minutes. Then a 15-minute EEG will be recorded out side of the scanner. Afterwards, the subject will be asked to lie down in a MRI scanner with the EEG cap on his/her scalp. The electrodes will be connected to a data collection system and electroencephalograms and fMRI will be collected and stored simultaneously onto the computer of the recording system. During the scan, subjects will be asked to close his/her eyes but keep awake. Or subjects may be also asked to perform some simple tasks. For example, subjects may be asked to tap his/her finger regularly or imagine some movements. The EEG-fMRI scan will take around 2 hours. After the recording session, subjects may want to wash his/her hair to clean out the electrically conductive gels. Although the EEG and MRI procedure can be performed as a routine clinical test, in this instance it is being performed for the research and not for his/her clinical care.

Subjects may also be asked to undergo EEG or fMRI recordings separately. In this case, subjects will be asked to perform similar simple tasks as those during EEG-fMRI procedure. The total time involved with either the special EEG session or the MRI (or MRI-EEG) session will be about one to two hours.

Approximately 50 subjects may be involved in this research at the University of Minnesota.
Visceral obesity (VO), characterized by excess fat around internal organs, is a recognized risk factor for gynecological tumors, including benign uterine leiomyoma (ULM) and malignant uterine leiomyosarcoma (ULS). Despite this association, the shared molecular mechanisms remain underexplored. This study utilizes an integrated bioinformatics approach to elucidate common molecular pathways and identify potential therapeutic targets linking VO, ULM, and ULS. We analyzed gene expression datasets from the Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs) in each condition. We found 101, 145, and 18 DEGs in VO, ULM, and ULS, respectively, with 37 genes overlapping across all three conditions. Functional enrichment analysis revealed that these overlapping DEGs were significantly enriched in pathways related to cell proliferation, immune response, and transcriptional regulation, suggesting shared biological processes. Protein-protein interaction network analysis identified 14 hub genes, of which TOP2A, APOE, and TYMS showed significant differential expression across all three conditions. Drug-gene interaction analysis identified 26 FDA-approved drugs targeting these hub genes, highlighting potential therapeutic opportunities. In conclusion, this study uncovers shared molecular pathways and actionable drug targets across VO, ULM, and ULS. These findings deepen our understanding of disease etiology and offer promising avenues for drug repurposing. Experimental validation is needed to translate these insights into clinical applications and innovative treatments.
SULAR®(nisoldipine) is an extended release tablet dosage form of the dihydropyridine calcium channel blocker nisoldipine. Nisoldipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester, C20H24N2O6, and has the structural formula:

Nisoldipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 388.4. SULAR tablets comprise three layers: a top barrier layer, a middle layer containing nisoldipine, and a bottom barrier layer. The erodible barrier layers and the hydrogel middle layer provide for the controlled release of the drug. SULAR tablets contain either 8.5, 17, 25.5 or 34 mg of nisoldipine for once-a-day oral administration.

Inactive ingredients in the formulation include: Hypromellose,hypromellose phthalate, lactose,glyceryl behenate, povidone, magnesium stearate, silicon dioxide,methacrylic acid copolymer, and sodium lauryl sulfate. Inactive ingredients in the film coating include: polydextrose, titanium dioxide, hypromellose, polyethylene glycol, iron oxide, and carnauba wax. Additionally, the 17 mg formulation contains FD&C Yellow #5.
Provided herein are methods of treating EIPH in a subject in need thereof. The methods comprise administering an effective amount of a pharmaceutical composition to the subject. In some embodiments, the pharmaceutical composition comprises a granuloma fluid, or a composition derived from a granuloma fluid. In some embodiments, the pharmaceutical composition comprises a cell. These pharmaceutical compositions may be administered by any suitable route of administration, and may be administered with one or more further therapeutic agents. Also provided are kits comprising pharmaceutical compositions for use with the methods provided herein.
Radiotherapy. Irradiation of the prostatic bed using megavoltage equipment with effective photon energies of greater than 4 MV.
In the palatal surgery combined OPR group, the participants will receive palatal surgery, then 12-week OPR. The program of OPR for this group is as the same of OPR group.
Single-cell RNA sequencing is a powerful tool to investigate the cellular makeup of tumor samples. However, due to the sparse data and the complex tumor microenvironment, it can be challenging to identify neoplastic cells that play important roles in tumor growth and disease progression. This is especially relevant for blood cancers, where neoplastic cells may be highly similar to normal cells. To address this challenge, we have developed partCNV and partCNVH, two methods for rapid and accurate detection of aneuploid cells with local copy number deletion or amplification. PartCNV uses an expectation-maximization (EM) algorithm with mixtures of Poisson distributions and incorporates cytogenetic information to guide the classification. PartCNVH further improves partCNV by integrating a hidden Markov model for feature selection. We have thoroughly evaluated the performance of partCNV and partCNVH through simulation studies and real data analysis using three scRNA-seq datasets from blood cancer patients. Our results show that partCNV and partCNVH have favorable accuracy and provide more interpretable results compared to existing methods. In the real data analysis, we have identified multiple biological processes involved in the oncogenesis of myelodysplastic syndromes and acute myeloid leukemia.
Mechanisms underlying p53-mediated protection of the replicating genome remain elusive, despite the quintessential role of p53 in maintaining genomic stability. Here, we uncover an unexpected function of p53 in curbing replication stress by limiting PARP1 activity and preventing the unscheduled degradation of deprotected stalled forks. We searched for p53-dependent factors and elucidated RRM2B as a prime factor. Deficiency in p53/RRM2B results in the activation of an NRF2 antioxidant transcriptional program, with a concomitant elevation in basal PARylation in cells. Dissecting the consequences of p53/RRM2B loss revealed a crosstalk between redox metabolism and genome integrity that is negotiated through a hitherto undescribed NRF2-PARP1 axis, and pinpoint G6PD as a primary oxidative stress-induced NRF2 target and activator of basal PARylation. This study elucidates how loss of p53 could be destabilizing for the replicating genome and, importantly, describes an unanticipated crosstalk between redox metabolism, PARP1 and p53 tumor suppressor pathway that is broadly relevant in cancers and can be leveraged therapeutically.
The safety and efficacy of CANCIDAS in the treatment of esophageal candidiasis was evaluated in one large, controlled, noninferiority, clinical trial and two smaller dose-response studies.

In all 3 studies, patients were required to have symptoms and microbiological documentation of esophageal candidiasis; most patients had advanced AIDS (with CD4 counts <50/mm3).

Of the 166 patients in the large study who had culture-confirmed esophageal candidiasis at baseline, 120 had Candida albicans and 2 had Candida tropicalis as the sole baseline pathogen whereas 44 had mixed baseline cultures containing C. albicans and one or more additional Candida species.

In the large, randomized, double-blind study comparing CANCIDAS 50 mg/day versus intravenous fluconazole 200 mg/day for the treatment of esophageal candidiasis, patients were treated for an average of 9 days (range 7-21 days). Favorable overall response at 5 to 7 days following discontinuation of study therapy required both complete resolution of symptoms and significant endoscopic improvement. The definition of endoscopic response was based on severity of disease at baseline using a 4-grade scale and required at least a two-grade reduction from baseline endoscopic score or reduction to grade 0 for patients with a baseline score of 2 or less.

The proportion of patients with a favorable overall response was comparable for CANCIDAS and fluconazole as shown in Table 12.

The proportion of patients with a favorable symptom response was also comparable (90.1% and 89.4% for CANCIDAS and fluconazole, respectively). In addition, the proportion of patients with a favorable endoscopic response was comparable (85.2% and 86.2% for CANCIDAS and fluconazole, respectively).

As shown in Table 13, the esophageal candidiasis relapse rates at the Day 14 post-treatment visit were similar for the two groups. At the Day 28 post-treatment visit, the group treated with CANCIDAS had a numerically higher incidence of relapse; however, the difference was not statistically significant.

In this trial, which was designed to establish noninferiority of CANCIDAS to fluconazole for the treatment of esophageal candidiasis, 122 (70%) patients also had oropharyngeal candidiasis. A favorable response was defined as complete resolution of all symptoms of oropharyngeal disease and all visible oropharyngeal lesions. The proportion of patients with a favorable oropharyngeal response at the 5- to 7-day post-treatment visit was numerically lower for CANCIDAS; however, the difference was not statistically significant. Oropharyngeal candidiasis relapse rates at Day 14 and Day 28 post-treatment visits were statistically significantly higher for CANCIDAS than for fluconazole. The results are shown in Table 14.

The results from the two smaller dose-ranging studies corroborate the efficacy of CANCIDAS for esophageal candidiasis that was demonstrated in the larger study.

CANCIDAS was associated with favorable outcomes in 7 of 10 esophageal C. albicans infections refractory to at least 200 mg of fluconazole given for 7 days, although the in vitro susceptibility of the infecting isolates to fluconazole was not known.
Colorectal anastomotic leakage (CAL) remains a feared complication after colorectal surgery and requires prompt detection and proper treatment. With the upswing of fast-track recovery programs in recent years this challenge has increased, as clinical features may only arise after discharge. Therefore, identification of the best diagnostic tools is of utmost importance, also since early treatment is associated with high success rates. Diagnostic tools range from general screening tools to invasive procedures to assess the severity of the leak. Laboratory tests, in particular the inflammation biomarkers C-reactive protein and procalcitonin, have a significant role in the detection of CAL after colorectal surgery. As these biomarkers are unspecific for CAL, additional imaging should be performed when blood levels are elevated. The golden standard for the detection of AL after colonic resections is a computed tomography (CT-scan). If tolerated, a contrast medium should be administered rectally to enhance diagnostic accuracy. When suspicion of CAL remains high despite negative previous tests, further endoscopy examination should be conducted. However, endoscopic examinations become more suitable for the early diagnostic work-up after rectal resections. This review aims to provide an overview of current diagnostics for the screening and assessment of the severity of CAL after colorectal surgery.
The invention discloses a herbal tea for treatment and prevention of hemorrhoids, hematochezia, prolapse of anus, constipation and a preparation method thereof. The herbal tea is made from the following raw materials by weight percentage: 30-50% of deep sea white eel, 20-40% of auricularia auricula, 10-20% of sow thistle, and 10-20% of taro. The taro is white taro, the auricularia auricular is black fungus, and the sow thistle is south sow thistle. The nutritious herbal tea for hemorrhoids and gastrointestinal anus provided by the invention has high activity, fast effect and good effect, can easily play a role in treating prolapse of anus and constipation in a short time after drinking, is especially effective for internal hemorrhoid and hematochezia patients, and can quickly cut off hemorrhoid nutrient vessels so as to make hemorrhoids atrophy and fall off and make hematochezia disappear. The herbal tea provided by the invention not only can nourish the human gastrointestinal tract, but also can rapidly restore impaired elastic fibrocytes in stomach, intestine and anus to make gastrointestinal anus return to normal, remove stuffy stomach, stomach distension, dull stomachache and constipation, clear away the heart-fire and relieve restlessness, remove toxin and dispel the effects of alcohol. The herbal tea provided by the invention also has the advantages of strengthening strength, memory and immunity, decreasing internal heat and eliminating halitosis, etc.
FIELD: medicine, oncology. SUBSTANCE: invention proposes to administrate in body antihormones, for example, the preparation showing simultaneously both anti-estrogenic and anti-androgenic effect. Preparation is prescribed in the dose 1.2-1.5 mg, dissolved in 3 ml of 0.9% sodium chloride before use and administrated in body for 30-40 days. Treatment and prophylaxis course is repeated in 3-4 months if necessary. Invention can be used for treatment of both men and women suffering with estrogen- and androgen-depending tumors. EFFECT: enhanced effectiveness of treatment, decreased complications. 2 tbl, 8 ex
Roboticists often imbue robots with human-like physical features to increase the likelihood that they are afforded benefits known to be associated with anthropomorphism. Similarly, deepfakes often employ computer-generated human faces to attempt to create convincing simulacra of actual humans. In the present work, we investigate whether perceivers' higher-order beliefs about faces (i.e., whether they represent actual people or android robots) modulate the extent to which perceivers deploy face-typical processing for social stimuli. Past work has shown that perceivers' recognition performance is more impacted by the inversion of faces than objects, thus highlighting that faces are processed holistically (i.e., as Gestalt), whereas objects engage feature-based processing. Here, we use an inversion task to examine whether face-typical processing is attenuated when actual human faces are labeled as non-human (i.e., android robot). This allows us to employ a task shown to be differentially sensitive to social (i.e., faces) and non-social (i.e., objects) stimuli while also randomly assigning face stimuli to seem real or fake. The results show smaller inversion effects when face stimuli were believed to represent android robots compared to when they were believed to represent humans. This suggests that robots strongly resembling humans may still fail to be perceived as "social" due pre-existing beliefs about their mechanistic nature. Theoretical and practical implications of this research are discussed.
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some point. Evidence-based guidance for patients, clinicians, and policymakers on rational discontinuation strategies is vital to enable the best, personalized treatment for any given patient. Nonetheless, there is a scarcity of guidelines on discontinuation strategies. In this perspective, we therefore summarize and critically appraise the evidence on discontinuation of six major psychotropic medication classes: antidepressants, antipsychotics, benzodiazepines, mood stabilizers, opioids, and stimulants. For each medication class, a wide range of topics pertaining to each of the following questions are discussed: (1) Who can discontinue (e.g., what are risk factors for relapse?); (2) When to discontinue (e.g., after 1 year or several years of antidepressant use?); and (3) How to discontinue (e.g., what's the efficacy of dose reduction compared to full cessation and interventions to mitigate relapse risk?). We thus highlight how comparing the evidence across medication classes can identify knowledge gaps, which may pave the way for more integrated research on discontinuation.
7832. Ruthrauff, W. M. June 16, 1914, [Convention date.] Dentifrices.-A dentifrice to remove the protein or mucin film on teeth comprises a proteolytic enzyme and an agent to render such enzyme active as a digestant, together with an abrasive agent. An example comprises 28 oz. of tricalcium phosphate, 2¢ drams of oil of peppermint, 4 drams of gum tragacanth, 12 drams of sugar, and 16 fluid oz. of solution of pepsin acidulated with hydrochloric acid not exceeding 5 per cent. Petroleum jelly may be added in any proportion. The oil of peppermint, sugar, and gum tragacanth may be replaced by other flavouring, sweetening, and binding agents. Instead of pepsin, other proteolytic enzymes may be employed with acid calcium phosphate in the same manner as pepsin. Pancreatin, however, must be used with an alkaline or neutral base, such as tricalcium phosphate, precipitated chalk, carbonate of magnesia, or milk of magnesia. The composition may be made into a powder or paste.
A randomized clinical trial will be conducted with adult women randomly allocated into two groups - self-compassion (n=38) or diet approach (n=38) - that will follow over eight weeks. Each group will have weekly meetings of 1 hour, working on different subjects related to self-compassion or dietary choices each week, according to each group. The study outcomes are body dissatisfaction, disordered eating, and self-compassion levels, measured through validated questionnaires. Data will be analyzed using Statistical Package for Social Science for Windows software, and differences between the two groups will be evaluated by the Student's T-test or the Mann-Whitney U test, according to sample distribution. The Chi-square test will analyze the associations between the type of approach and all measured outcomes. Significant differences will be considered when the P value \<0.05. As a result, the investigators expect that self-compassion will improve body dissatisfaction and attenuate disordered eating more than the diet approach.