anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Psoriasis (Ps), a chronic inflammatory disease affecting approximately 2 % of the global population, has been associated with an increased risk of liver cancer in observational studies. However, their causal relationships as well as underlying shared molecular mechanisms between Ps and liver cancer remain unclear. Using bidirectional Mendelian randomization analysis, we revealed that a genetic predisposition to liver cancer increased the risk of Ps in European and East Asian populations but not the other way around. Moreover, we analyzed three transcriptomic datasets of patients with Ps and liver cancer from open-source databases. Differentially expressed genes (DEGs) and disease-specific gene co-expression module analyses revealed that cell-cycle dysregulation was the shared mechanism of Ps and liver cancer. Moreover, we identified a rank-conservative gene signature shared between these two diseases, which demonstrated significance in diagnostic and prognostic predictions. These findings provided valuable insights into the interconnections between Ps and liver cancer, which may be helpful to guide therapeutic management.
Hepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the sympathetic innervation being extensively studied, while the parasympathetic efferent innervation is less understood despite its potential importance. In this study, we investigate the consequences of disrupted brain-liver communication on hepatic lipid metabolism in mice exposed to obesogenic conditions. We found that a subset of hepatocytes and cholangiocytes are innervated by parasympathetic nerve terminals originating from the dorsal motor nucleus of the vagus. The elimination of the brain-liver axis by deleting parasympathetic cholinergic neurons innervating the liver prevents hepatic steatosis and promotes browning of inguinal white adipose tissue (ingWAT). The loss of liver-innervating cholinergic neurons increases hepatic Cyp7b1 expression and fasting serum bile acid levels. Furthermore, knockdown of the G protein-coupled bile acid receptor 1 gene in ingWAT reverses the beneficial effects of the loss of liver-innervating cholinergic neurons, leading to the reappearance of hepatic steatosis. Deleting liver-innervating cholinergic neurons has a small but significant effect on body weight, which is accompanied by an increase in energy expenditure. Taken together, these data suggest that targeting the parasympathetic cholinergic innervation of the liver is a potential therapeutic approach for enhancing hepatic lipid metabolism in obesity and diabetes.
Phytoalexin sakuranetin functions in resistance against rice blast. However, the mechanisms underlying the effects of sakuranetin remains elusive. Here, we report that rice lines expressing resistance (R) genes were found to contain high levels of sakuranetin, which correlates with attenuated endocytic trafficking of plasma membrane (PM) proteins. Exogenous and endogenous sakuranetin attenuates the endocytosis of various PM proteins and the fungal effector PWL2. Moreover, accumulation of the avirulence protein AvrCO39, resulting from uptake into rice cells by Magnaporthe oryzae, was reduced following treatment with sakuranetin. Pharmacological manipulation of clathrin-mediated endocytic (CME) suggests that this pathway is targeted by sakuranetin. Indeed, attenuation of CME by sakuranetin is sufficient to convey resistance against rice blast. Our data reveals a mechanism of rice against M. oryzae by increasing sakuranetin levels and repressing the CME of pathogen effectors, which is distinct from the action of many R genes that mainly function by modulating transcription.
According to the present invention, a customized skin gel pack is a self-produced customized skin gel pack which can be customized in real-time by a purchase user. The customized skin gel pack includes a base product. The base product includes: a base composition; and a base container part storing the base composition. The base composition contains a specified base component, is stored in a liquid state that can be mixed with a functional product, and is solidified under specified conditions to become a gel state which can be molded into a skin gel pack detachably attached to a specified skin area. N (N>=1) functional products store N functional compositions with specified functional components in N functional container parts as much as the volume of the specified N functional compositions. The base product includes a specified spare storage volume which is secured or capable of being secured. Accordingly, a purchase user can put n (1<=n<=N) functional compositions stored in n functional container parts, specified from among the N functional products by the purchase user, into the base container part and mix the n functional compositions with the base composition. According to the present invention, a user can produce a customized skin gel pack optimized for his or her current skin condition.
The invention belongs to the technical field of Chinese herbal medicines, and discloses a preparation for treating burns and scalds and a preparation method thereof. The oil preparation is used as a base and is compatible with raw materials for clearing away heat and toxic materials, relieving pain and diminishing inflammation, promoting blood circulation and removing blood stasis, and removing necrotic tissue and promoting granulation, so that the effects of moistening, quickly relieving pain and no secondary wound injury are achieved. It can be used for treating burn, scald, hemorrhoid, and chilblain. Does not need skin grafting or limb amputation, prevents infection, resists infection, treats infection, is safe and does not leave scars. The oil gun promotes the active ingredients of the medicinal materials to be fully dispersed into the oil agent, and the slightly cold characteristic of part of the raw materials is well removed. The processing temperature and the processing time are convenient for prolonging the processing time under the precondition that each Chinese herbal medicine has the function, ensuring that the effective components of each medicinal material can penetrate into the oil agent to the maximum extent and ensuring the high-efficiency treatment of the finished product. Adding the sclerosant and borneol for further healing sore and promoting granulation and clearing heat and relieving pain, and the finished product is paste and is beneficial to transportation and storage. The processed materials are brown, and have hemostatic and toxic materials clearing away effects.
<P>PROBLEM TO BE SOLVED: To provide a new serine protease-inhibiting protease gene, to provide the protein, and to provide a method for efficiently evaluating an activity- adjusting agent for the protein.  <P>SOLUTION: A DNA comprises a specific base sequence originated from human being, and a Kunitz type serine protease-inhibiting protein encoded in the DNA. An antisense nucleic acid against the DNA sequence. A method for evaluating the activity-adjusting agent for the protein. The protein is a protein which can cause the crisis or advance of an inflammatory disease and is extremely useful on the development of medicines for preventing or treating the inflammatory disease and the like.  <P>COPYRIGHT: (C)2003,JPO
BACKGROUND: With increasing implementation of Enhanced Recovery After Surgery protocols and rising demand for inpatient hospital beds accentuated by COVID-19, there has been interest in same-day discharge (SDD) for bariatric surgery. The aim of this study was to determine the national trends, safety profile, and risk factors for complications of SDD for minimally invasive bariatric surgery.
STUDY DESIGN: We analyzed the MBSAQIP database from 2016 to 2021 to characterize trends in SDD for minimally invasive bariatric operation. Multivariate logistic regression was performed on preoperative patient characteristics predictive of increased complications associated with SDD. A comparative analysis of postoperative outcomes within 30 days was performed for SDD and admission after 1:1 nearest neighbor propensity score matching for patient demographics and preoperative comorbidities.
RESULTS: SDD increased from 2.4% in 2016 to 7.4% in 2021. Major preoperative factors associated with increased complications for SDD included Black race, history of MI, renal insufficiency, deep vein thrombosis, and smoking. SDD for Roux-en-Y gastric bypass had 72% increased risk of postoperative complications compared with sleeve gastrectomy. The overall major complications were lower in SDD cohort vs admission cohort (odds ratio [OR] 0.62, p < 0.01). However, there was a significant increase in deaths within 30 days (OR 2.11, p = 0.01), cardiac arrest (OR 2.73; p < 0.01), and dehydration requiring treatment (OR 1.33; p < 0.01) in SDD cohort compared with admission cohort.
CONCLUSIONS: Nationally, there has been a rise in SDD for bariatric operation from 2016 to 2021. Matched analysis demonstrates that SDD is associated with a significantly higher mortality rate. Additionally, the risk of complications with SDD is higher for RYGB compared with sleeve gastrectomy. Therefore, further studies are required to appropriately select patients for whom bariatric surgery can be safely performed as an outpatient.
Iron plays an important role in oxidation and reduction reactions, which have a very important place in the continuation of life. Iron plays an essential role in these reactions because it can easily gain and lose electrons in redox reactions. Iron is mostly found in the heme molecule in organisms. However, iron has structural and functional importance for many enzymes and proteins other than heme. Iron deficiency (ID) is the most common nutritional deficiency in children worldwide. ID is more common in socio-economically developing geographies. However, it is still an important problem in developed countries. A plasma ferritin level below 12 mg/L is defined as ID, which is often used synonymously with iron deficiency anemia (IDA). However, ID develops before anemia occurs. Weakness, fatigue, tiring quickly, insomnia, and regression in neuro-cognitive functions may occur in ID that precedes the signs of anemia. With the development of anemia, the clinical diagnosis of IDA is fully revealed.

In ID that occurs in infancy, psychomotor development is adversely affected, and the development of cognitive functions slows down or even stops. Immune system functions regress. Although iron treatment can reverse these negative effects, some effects are permanent. Therefore, prevention of ID is more important than treatment. In addition, it is easier and cheaper to prevent ID and IDA than to treat them. It is a health policy to recommend iron prophylaxis to children aged 4-12 months in the Republic of Turkey.

Adding iron-rich foods to the diet, adequate breast milk intake, and prophylaxis with iron preparations can be used to prevent ID and IDA. However, there are different data in the literature on the use of prophylactic iron preparations.
Apply LEFT treatment to LEFT arm or (vica versa) RIGHT treatment to RIGHT arm. Will not be known to the subject which arm is on the active treatment and which is on the placebo control. Applied twice daily for 12 weeks. Each subject will have one arm/hand that is either a)the experimental treatment or b) the placebo control.
Vitamin K is a group name for the naturally occurring phylloquinone (K1) and menaquinones (MK-n; K2). The latter can be subdivided into the short-chain (e.g. MK-4) and the long-chain (e.g. MK-7, MK-8, and MK-9) menaquinones. Earlier studies have shown that high vitamin K intake leads to improved bone and vascular health by increased carboxylation of vitamin K-dependent proteins in these tissues. In the dietary range, MK-7 has been suggested to be the most effective cofactor for the carboxylation of Gla-proteins, such as osteocalcin (OC) and matrix-Gla protein (MGP).Until now, no randomized controlled trial has compared the efficacy of K1 versus MK-7 in a nutritional dose range. The investigators are therefore interested to compare the effects of K1 and MK-7 on OC and MGP carboxylation after supplementing these vitamins at a dose not exceeding the RDA.
This letter addresses the importance of enhancing post-craniotomy care for primary brain tumor patients by leveraging insights from Rongqing Li et al.'s study on symptom networks. The study identified key central and bridge symptoms, such as sadness and difficulty understanding, which influence post-surgical recovery and quality of life. It also highlighted that patients with noninvasive tumors showed more cohesive symptom networks compared to those with invasive tumors. However, the study had limitations, including a short observation period and reliance on self-reported data, which restricted the depth of the findings.To optimize recovery, integrating artificial intelligence (AI) and machine learning (ML) could revolutionize post-craniotomy care. AI can assist with surgical planning, predict complications, and monitor recovery through wearable devices and real-time alerts. Natural Language Processing (NLP) can improve symptom detection from electronic health records, enhancing clinical decision-making. Despite the potential of these technologies, ethical concerns regarding data privacy and AI-generated report accuracy must be addressed. Future research should focus on long-term outcomes and refining AI applications to improve post-craniotomy symptom management and overall patient outcomes.
Production of microcapsules comprises: (1) preparing an oil phase from an oil soluble active ingredient with a m.pt. of below 20 [deg]C and a wax with a m.pt. of above 20 [deg]C; (2) mixing the oil phase with an aqueous solution of a polymer P1 at a temperature above the m.pt. of the wax; and (3) cooling the resulting oil in water emulsion and contacting it with an aqueous solution of a polymer P2. Production of microcapsules with an average diameter of 0.0001-5 mm comprises: (1) preparing an oil phase from an oil soluble active ingredient with a m.pt. of below 20 [deg]C and a wax with a m.pt. of above 20 [deg]C; (2) mixing the oil phase with an aqueous solution of a polymer P1 at a temperature above the m.pt. of the wax; and (3) cooling the resulting oil in water emulsion and contacting it with an aqueous solution of a polymer P2, where one of P1 and P2 is anionic and the other is cationic. An independent claim is also included for microcapsules produced as above.
Observation of lung changes over time by hyperpolarized xenon MRI on CF patients heterozygous for F508del CFTR mutation at similar timepoints to treatment group. Control subjects are not be eligible to be clinically prescribed orkambi based on FDA approval.
PROBLEM TO BE SOLVED: To provide a cosmetic having an excellent touch feeling, adhesion and compatibility to and with the skin, humectant effects, uniformity of an applied cosmetic, and the durability of the cosmetic effects. SOLUTION: This cosmetic is obtained by formulating complexly treated powder obtained by spraying and drying a slurry comprising 2-10 pts.wt. hydrophilic high-molecular compound, 0.5-7 pts.wt. ester-based oil, 100 pts.wt. powder and 300-1,000 pts.wt. solvent.
Group one will meet with a family therapist for one 90 minute session where the main focus will be on providing psychoeducation on grief and communication to both children and parents. This arm receives only the first session of the grief and communication family intervention.
PROBLEM TO BE SOLVED: To prepare a treating agent for acute lung injury caused by an indirect cause such as septicemia by a gram-negative bacteria, by using anti-interleukin-8 antibody as an active ingredient. SOLUTION: The subject treating agent includes anti-interleukin-8 antibody (anti-IL-8 antibody) as an active ingredient. The anti-IL-8 antibody is preferably a monoclonal antibody derived from a mammal. The especially preferable antibody is WS-4 antibody. The monoclonal antibody is obtained by immunizing an animal by using the IL-8 as a sensitizing antibody, performing cell fusion of the immunized cells with myeloma cells of parent cells, further screening and cloning the obtained hybridoma to provide a hybridoma producing the objective antibody and culturing the hybridoma. The WS-4 antibody is obtained from mouse hybridoma WS-4 (FERM BP-5507). The objective treating agent can be orally administered.
The existing paradigm for testing the effect of treatments is the double-blind RCT comparing an active drug to an inactive placebo. This comparison is done in order to control for contextual and psychological factors such as the patients' treatment expectations - a key factor in placebo responses. However, recent study results have indicated that some assumptions underlying the RCT may be incorrect and may lower the assay sensitivity and miscalculate the actual drug response. The so-called balanced placebo design targets the shortcomings of the RCT by balancing the information given to the patients (correct or false) with the actual treatment administered (active treatment or placebo). In this project, the aim is to examine if the magnitude of the drug effect differs when estimated based on the RCT design and when based on BPD, conditioning on the information provided to the recipient. Additionally, it will also be tested if active drug response and the placebo response interact in acute migraine treatment.

Patients suffering from episodic migraine will go through six treatment conditions in randomized order. They will receive acute migraine treatment (a sumatriptan pill) or inactive treatment (a placebo pill) in the event of a developing migraine attack. Using a clinical within-subjects design, the patients receive 1) sumatriptan or 2) placebo and are told that they receive a) sumatriptan or placebo, b) sumatriptan , or c) placebo. All treatments and accompanying treatment descriptions will be administered at home.
Grammar: In the science + grammar condition, focused stimulation plus explicit instruction will be employed. Focused stimulation an intervention commonly used to target expressive language, will be used to treat complement clauses during the FOSS activities.. The active ingredients are models (30) and recasts (5 per child) of the target structure (e.g., "You measured how long the ramp is"). Recasts occur when an examiner responds to a child's naturally occurring utterance by expanding or extending the child's utterance to include a target grammatical structure. Focused stimulation will be supplemented with explicit instruction using choral production and visual supports (3x per lesson) and a definition of the meaning of the structure (1 per lesson).
PURPOSE: Novel anti-glaucoma agent is provided, which reduces intraocular pressure (IOP), increases blood stream of retin a but has no adverse reaction. CONSTITUTION: Provided is an anti-glaucoma agent comprising cocaine(a) or sulpiride(b)and pharmaceutical diluents. Eye ointment and eye solution preparation are manufactured by using cocaine and sulpiride which reduce IOP. The eye solution preparation of cocaine is prepared by soluting the cocaine in NaCl solution of 0.9%, The eye solution preparation of sulpiride is prepared by mixing with propylene glycol. buffer, diluent, lubricant, stabilizer such as hydroxypropyl beta-cyclodextrin or carboxy methyl cellulose, anti-bacterial agent such as chlorobutanol, and a coupling agent can be added in cocaine or sulpiride for treatment, pH of the agent is controlled by Na2HPO4 or NaH2PO4. Base ingredient of eye ointment can be selected from white vaseline ointment, mineral oil, or water-free sheep oil.
PURPOSE:To obtain an antineoplastic agent capable of suppressing hyperplasia by incorporating an acidulant in an existing medicine to gradually kill malignant tumor cells by the acidulant preparation through repeated use of the preparation. CONSTITUTION:This antineoplastic agent can be obtained by incorporating an existing medicine with an acidulant, esp. as the form of infusion prepared by incorporating dilute hydrochloric acid into chitin constituting the skin of arthropod, the shell of mollusk or the cell membrane of fungi. The chitin, which is a nitrogen-contg. polysaccharide, as a kind of mucopolysaccharide, is dissolved in vivo, however, is decomposed into chitosan and acetic acid, therefore, being harmless to the human body. Continuous infusion at an interval of this acidulant (hydrochloric acid)-added agent suppresses hyperplasia which causes tumors; this agent can therefore be used as an injection or drip. By using this agent, the necessity of any incisional operation can be obviated even in vivo, and therapies conducted in the initial stage of tumors is enabled.
ABSTRACT OF THE DISCLOSURE         A structure usable as an ultrafiltration membrane has membranes with uniform continuous pores. The membranes are linked together to form a stable unsupported film, or are connected to a carrier, preferably a porous one. Each membrane consists of protein or protein-containing molecules which are arranged to form a crystal lattice defining continuous pores free of the said molecules. Such membranes can be formed by suspending or dissolving protein-containing molecules derived from a surface layer of a cell wall of a procaryote microorganism in an aqueous medium which contains at least one of a chaotropic agent and a surfactant or has a predetermined pH value followed by a recrystallization process designated as self-organization. The molecules are preferably deposited on or into the carrier and are cross-linked intra- or intermolecularly or with the carrier, respectively, through foreign molecules. The resulting structure is suitable for use as a separating organ for a gas separation or for an ion exchange process, as well as for use as a carrier structure for other semi-permeable membranes, such as hyperfiltration membranes. Moreover, the membrane in vesicle form can serve as a chromatography column and, in the form of film, as envelope material for the most varied substances.
Although idiopathic scoliosis (IS) is the most common type of scoliosis, no studies have evaluated the effectiveness of physical therapy exercises for managing low back pain (LBP) in this population. Spinal stabilization exercises are of particular importance in adolescents with IS due to possible reduced spinal stability from structural deformity. Spinal stabilization exercises have been reported to prevent recurrent episodes of LBP in the adult population. However, standardized treatment options cannot be recommended for LBP in adolescents with IS, because the investigators are not certain if spinal stabilization exercises will have the same effect on this patient population. Given the high prevalence of LBP in AIS and limited evidence of conservative interventions, researching the effectiveness of spinal stabilization exercises is warranted.

Currently, there are two common practices for managing adolescents with IS who have LBP: 1) supervised physical therapy and 2) a one-time treatment with no follow-up. No studies have examined which of these two approaches is superior. This study will provide information on optimal management of LBP in AIS. If there is no difference in outcomes between these two approaches, a one-time visit will be the optimal choice of treatment since it is more cost-effective and less burdensome for the family. If the outcomes favor the eight-week supervised physical therapy, specifically the spinal stabilization exercises, this treatment approach should be recommended for managing LBP in AIS.