anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: cosmetology. SUBSTANCE: the suggested cosmetic composition contains active cosmetic component (for example, deodorizing active component, antiperspirant active component, sun factor, repellent for insects and/or fungicidal preparation) and silicone gelatinous component. The latter includes (a) volatile silicone material and (b) organopolysiloxane material as gelating agent able to form gel after being mixed with volatile silicone material. Organopolysiloxane material could be the product of reaction of siloxane polymer with terminal vinyl and hydride coupling agent. Composition could be obtained at mixing active cosmetic component and silicone gelatinous component at environmental temperature. This composition leaves no visible residue upon skin, makes skin to be silky without feeling fatness and is characterized by decreased synerisis against silicone. EFFECT: higher efficiency. 29 cl, 11 ex
Thermoplastic compositions for cones for filling root canals include guttapercha in association with calcium hydroxide. This association provides the advantages of both guttapercha and calcium hydroxide in cones, simplifying endodontic treatment by preventing a need for dressing or apical tampons. The cones provide a continuous source of calcium hydroxide, regardless of the type of cement used with the cones. Low permeability of the cones ensures that release of calcium hydroxide is slow. Additional ingredients provide rigidity, radio-opacity and coloring. The additional ingredients include zinc oxide, aluminum oxide, barium sulfate, kaolin, and colorant. Methods for making the dental cones are also provided.
Participants will receive a single dose of INDV-2000 orally on Day 1 under fasted conditions and a single dose of INDV-2000 after a high-fat breakfast on Day 8. Dose to be determined based on a well-tolerated dose studied in Part I.
This arm is consist of 12 subject. Micardis 80mg alone for 6 day during period 1. Crestor 20mg and Micardis 80mg for 6 day during period 2.
Combination ribavirin capsules/INTRON A therapy must not be used by females who are pregnant or by males whose female partners are pregnant. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients taking combination ribavirin capsules/INTRON A therapy. Combination ribavirin capsules/INTRON A therapy should not be initiated until a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy. Females of childbearing potential and males must use two forms of effective contraception during treatment and during the 6 months after treatment has been concluded. Significant teratogenic and/or embryocidal effects have been demonstrated for ribavirin in all animal species in which adequate studies have been conducted. These effects occurred at doses as low as one twentieth of the recommended human dose of ribavirin capsules. If pregnancy occurs in a patient or partner of a patient during treatment or during the 6 months after treatment stops, physicians are encouraged to report such cases by calling the Ribavirin Pregnancy Registry at 1-800-593-2214. See boxed CONTRAINDICATIONS AND WARNINGS. See WARNINGS.

Ribavirin capsules in combination with INTRON A Injection is contraindicated in patients with a history of hypersensitivity to ribavirin and/or alpha interferon or any component of the capsule and/or injection.

Patients with autoimmune hepatitis must not be treated with combination ribavirin capsules/INTRON A therapy.
The invention relates to diclofenac zinc complexes with anti-inflammatory activity and a preparation method thereof and belongs to the technical field of complex synthesis and pharmaceutical chemistry. The two complexes utilize zinc ions as central ions. The complex 1 utilizes diclofenac and 1,10-phenanthroline as ligands and is a six-fold coordinated mononuclear structure. Each one of the complex molecules contains 2 deprotonated diclofenac molecules, a phenanthroline molecule and one zinc ion. The complex 2 utilizes diclofenac and 2,2'-bipyridine as ligands and is a six-fold coordinated mononuclear structure. Each one of the complex molecules contains 2 deprotonated diclofenac molecules, a 2,2'-bipyridine molecule and one zinc ion. A test proves that the complexes 1 and 2 respectively have rat toe swelling inhibition rates of 88.4% and 86.7% and respectively have gastric ulcer indexes of 2.2 and 9; and diclofenac sodium has a rat toe swelling inhibition rate of 36.1% and a gastric ulcer index of 24.4. Compared with the ligands, the two complexes have good anti-inflammatory activity and low stomach side-effects and can be used for preparation of anti-inflammatory drugs.
Determination of delta 9-tetrahydrocannabinol (THC) and its metabolites , and of cannabidiol and its metabolites in blood and breast-milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Realization of THC/CBD ratio; qualitative research in mother's and breast-fed child's urine for the presence of cannabinoids (THC, CBD and its metabolites).
INTRODUCTION: The purpose of this study was to characterize the morphological variations in the quadratus femoris muscle (QF) and to create an anatomical classification that could be used in the planning of surgical procedures in this area, radiological imaging, and rehabilitation.
MATERIALS AND METHODS: Ninety-two lower limbs from 46 cadavers, fixed in 10 % formalin solution, were examined.
RESULTS: The QF muscle was present in all specimens. According to morphology, the QF muscle was classified into three types. The most common type was Type I, characterized by one muscular belly (78.3 %), while the second most common type was Type II, characterized by two bellies, was observed in 17.4 % of cases. The rarest type was Type III. It was characterized by three bellies and was found in 4.3 % of the cases.
CONCLUSIONS: The current classification system on quadratus femoris morphological variability is novel. Morphological variants may contribute to clinical issues, such as the ischiofemoral impingement syndrome, that could arise from type I quadratus femoris. Hence, the current study may be applicated to planning surgical procedures, imaging, and rehabilitation.
The present invention relates to a single particle nanometer garlic oil micro capsule. The present invention is composed of effective components of single particle garlic and wall material embedded outside the effective components of single particle garlic. The wall material is made of N-LOK modified starch or beta-CD. The effective components comprise garlic oil, allicin, ajoenes, selenium and germanium. A preparation method comprises the following steps: garlic which is used as raw material and is cleaned is positioned in a container; ethanol whose concentration is from 70 to 100%, and methylene chloride or aqueous solvent are added; the container with the garlic, the ethanol, and the methylene chloride or the aqueous solvent are put into the multi-dimensional microwave environment for multi-dimensional microwave induction extraction, the extraction temperature is from 40 to 50 DEG C, the extraction pressure is from 0.06 to 0.12Mpa, and the effective components are extracted into the solvent; the solvent with the effective components is filtered to be put into a concentration pot, and through decompression concentration, mixed extract which contains the effective components of the garlic is obtained; through condensing, the effective components are obtained; N-LOK modified starch or beta-CD is added into concentrated solution, and through mixing at the low temperature, mixture liquid is prepared; the mixture liquid is put into an annular nanometer jet flow atomizer to be atomized and dried, the single particle nanometer garlic oil micro capsule is prepared, and powder, tablets or capsules can be prepared. The present invention has the advantages that the extraction rate is high, active ingredients of a plant are not destroyed in general, etc.
Exosomal microRNAs (miRNAs) are novel, non-invasive biomarkers for facilitating communication and diagnosing cancer. However, only a few studies have investigated their function and role in the clinical diagnosis of breast cancer. To address this gap, we established a stable cell line, MDA-MB-231-CD63-RFP, and recruited 112 female participants for serum collection. We screened 88 exosomal miRNAs identified through microarray analysis of 231-CD63 and literature screening using real-time PCR; only exosomal miR-92b-5p was significantly increased in patients with breast cancer. It had a significant correlation with stage and discriminated patients from the control with an AUC of 0.787. Exosomal miR-92b-5p impacted the migration, adhesion, and spreading ability of normal human mammary epithelial recipient cells through the downregulation of the actin dynamics regulator MTSS1L. In clinical breast cancer tissue, the expression of MTSS1L was significantly inversely correlated with tissue miR-92b-5p, and high expression of MTSS1L was associated with better 10-year overall survival rates in patients undergoing hormone therapy. In summary, our studies demonstrated that exosomal miR-92b-5p might function as a non-invasive body fluid biomarker for breast cancer detection and provide a novel therapeutic strategy in the axis of miR-92b-5p to MTSS1L for controlling metastasis and improving patient survival.
The invention relates to the technical field of big data and a block chain, in particular to an intelligent medical settlement method and system based on the big data and the block chain. In the present invention, first medical expense payment information transmitted from a medical expense payment terminal is acquired. Second, first medical expense payment information is broadcast to each second block-node device. Then, the second medical fee collecting information transmitted by the medical fee collecting terminal is acquired. And searching corresponding first medical record information on the medical expense information block chain based on the second medical record information, and determining whether first payment amount information corresponding to the first medical record information is the same as second payment amount information corresponding to the second medical record information. And finally, if the first payment amount information is the same as the second payment amount information, sending the second payment amount information to the target financial platform. The invention can solve the problem that the conventional medical settlement technology is easy to charge by mistake.
Patients using this medication should receive the following information and instructions:

  1. The patient should be instructed to use these medications as directed (including the replacement of missed doses). These medications are not for any disorder other than that for which they are prescribed.
  2. Even if symptomatic relief occurs within the first few days of treatment, the patient should be advised not to interrupt or discontinue therapy until the prescribed course of treatment is completed.
  3. If symptoms of irritation develop, the patient should be advised to notify the physician promptly.
ABSTRACT    This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound.  In a preferred embodiment, the organ rich in mitochondria is the liver.  In a further preferred embodiment, the particles are substantially nonmagnetic.  In another preferred embodiment, the particles have a particle size of less than about 10 microns.     In a still further preferred embodiment, the insoluble manganese compound is a manganese salt.  The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate.     In another preferred embodiment, the composition of the present invention further comprises a surfactant.     The present invention is further directed to a method of preparing a magnetic resonance imaging composition useful for imaging an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound comprised of contacting a manganese source with a counter ion source for a time and under conditions sufficient for the formation of said insoluble manganese compound.  In a preferred embodiment, the contacting is by simultaneous admixing in an aqueous solution.     The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.
Identifying the association and corresponding types of miRNAs and diseases is crucial for studying the molecular mechanisms of disease-related miRNAs. Compared to traditional biological experiments, computational models can not only save time and reduce costs, but also discover potential associations on a large scale. Although some computational models based on tensor decomposition have been proposed, these models usually require manual specification of numerous hyperparameters, leading to a decrease in computational efficiency and generalization ability. Additionally, these linear models struggle to analyze complex, higher-order nonlinear relationships. Based on this, we propose a novel framework, KBLTDARD, to identify potential multiple types of miRNA-disease associations. Firstly, KBLTDARD extracts information from biological networks and high-order association network, and then fuses them to obtain more precise similarities of miRNAs (diseases). Secondly, we combine logistic tensor decomposition and Bayesian methods to achieve automatic hyperparameter search by introducing sparse-induced priors of multiple latent variables, and incorporate auxiliary information to improve prediction capabilities. Finally, an efficient deterministic Bayesian inference algorithm is developed to ensure computational efficiency. Experimental results on two benchmark datasets show that KBLTDARD has better Top-1 precision, Top-1 recall, and Top-1 F1 for new type predictions, and higher AUPR, AUC, and F1 values for new triplet predictions, compared to other state-of-the-art methods. Furthermore, case studies demonstrate the efficiency of KBLTDARD in predicting multiple types of miRNA-disease associations.
We evaluated the contribution of place of birth to ethnocultural inequality in pregnancy outcomes. We analyzed a cohort of 1,487,723 births between 1998 and 2019 among minority Anglophones and majority Francophones in Quebec, Canada. We estimated the association (adjusted risk ratio, RR; 95% confidence interval, CI) of language with preterm birth and stillbirth, and incorporated interaction terms to determine the contribution of place of birth and distance traveled. Compared with Francophones, minority Anglophones had a greater risk of preterm birth (RR 1.03; 95% CI 1.01-1.06) and were less likely to deliver farther from home (RR 0.95; 95% CI 0.94-0.95). Anglophones who delivered close to home had a higher risk of preterm birth (RR 1.07; 95% CI 1.04-1.11), whereas Anglophones who delivered farther had a lower risk (RR 0.69; 95% CI 0.64-0.75). Patterns were similar for stillbirth. Ethnocultural inequality in adverse birth outcomes may be influenced by place of birth.
The research introduces a traditional Chinese medicine personalized health intelligent management system based on an AI large model. The system relates to the technical field of traditional Chinese medicine term modules for data conversion of health data sensors. And comprehensively analyzing the recent transmission state of the health data transmitted to the AI traditional Chinese medicine large model server and the health data processed by the AI traditional Chinese medicine large model server, normalizing the health data, and calculating to obtain the available evaluation coefficients of the AI traditional Chinese medicine large model service health data. The available evaluation coefficients of the health data of the AI traditional Chinese medicine large model service are compared with the standard values and the health values. The technical field of the traditional Chinese medicine term module for data conversion of the health data sensor is combined with the analysis of the large AI traditional Chinese medicine model. The traditional Chinese medicine health data is helpful for finding possible problems in advance, measures are taken to treat the disease, the traditional Chinese medicine personalized health management service is provided, and the health data management efficiency and usability of healthy people are improved.
The conus artery (CA) supplies the right ventricular outflow tract (RVOT). ST-segment elevation in leads V1-3, which can resemble Brugada electrocardiogram (EKG) patterns, has been reported due to occlusion of the CA. A 68-year-old male was admitted to the hospital with a diagnosis of non-ST-elevation myocardial infarction. A coronary angiogram revealed a dissection in the conus artery, most likely caused by the catheter. Due to the small caliber of the CA, medical therapy was chosen as the course of action. However, after the procedure, an EKG showed changes consistent with features of both type-1 and type-2 Brugada patterns, with ST-segment elevations in leads V1-4. Subsequent coronary imaging revealed that the CA had progressed to total occlusion. Despite multiple attempts to gain reentry into the true lumen, they were unsuccessful. Based on the risk-benefit ratio, the decision was made to continue with medical therapy. This is the first reported case of CA occlusion induced by catheter dissection, which manifested as anteroseptal ST-segment elevation. The patient did not report any anginal symptoms or arrhythmic events, which contrasts with conventional knowledge. Not all CA obstructions or RVOT infarcts cause Brugada-like patterns. When they do, ST elevations tend to be less than those in true Brugada syndrome.
Fomepizole solidifies at temperatures less than 25°C (77°F). If the fomepizole solution has become solid in the vial, the solution should be liquefied by running the vial under warm water or by holding in the hand. Solidification does not affect the efficacy, safety, or stability of fomepizole. Using sterile technique, the appropriate dose of fomepizole should be drawn from the vial with a non-polycarbonate containing syringe and injected into  at least 100 mL of sterile 0.9% sodium chloride injection or dextrose 5% injection. Mix well. The entire contents of the resulting solution should be infused over 30 minutes. Fomepizole, like all parenteral products, should be inspected visually for particulate matter prior to administration.
In general, loperamide hydrochloride capsules should not be used when inhibition of peristalsis is to be avoided due to the possible risk of significant sequelae including ileus, megacolon and toxic megacolon. Loperamide hydrochloride capsules must be discontinued promptly when constipation, abdominal distention or ileus develop.

Treatment of diarrhea with loperamide hydrochloride capsules is only symptomatic. Whenever an underlying etiology can be determined, specific treatment should be given when appropriate (or when indicated).

Patients with AIDS treated with loperamide hydrochloride capsules for diarrhea should have therapy stopped at the earliest signs of abdominal distention. There have been isolated reports of toxic megacolon in AIDS patients with infectious colitis from both viral and bacterial pathogens treated with loperamide hydrochloride.
An estimated 4% of the adult population suffers from haemorrhoidal disease. In 1937 E. T. Milligan and C. N. Morgan described a method for operating piles that still is regarded "the gold standard" in the treatment of severe haemorrhoidal disease. This procedure is followed by a prolonged and painful recovery. To overcome the long recovery often combined with long sick leaves, less invasive methods for treating piles have been introduced during the last decade. However, few studies have compared patient benefits and the long term outcome of these techniques, and the choice of treatment is often based on the skills and experience of the individual surgeon. A new and promising mini invasive approach utilizes doppler-guided ligation of the haemorrhoidal arteries. All haemorrhoidal arteries are identified and then ligated approximately 2 cm above the anal canal. Thereafter the rectal mucosa with the piles is repositioned and fixed in the rectum with running sutures. This procedure is termed Recto Anal Repair (RAR) and leads to shrinking of the piles and restored anatomy of the anus and the rectum. The investigators want to execute a randomized, consecutive, prospective, controlled study with long term follow up to compare the RAR procedure to Milligans operation for the treatment of severe haemorrhoidal disease.

The primary goals are evaluation of pain and sick leave 7, 14 and 21 days after surgery and reported reduction of pile symptoms after 3, 6 and 12 months. In addition the investigators want to compare the overall satisfaction with the two procedures.
Chromosomal instability (CIN) is a source of genetic variation and is highly linked to the malignance of cancer. Determining the degree of CIN is necessary for understanding the role that it plays in tumor development. There is currently a lack of research on high-resolution characterization of CIN and the relationship between CIN and cell mechanics. Here, a method to determine CIN of breast cancer cells by high resolution imaging with atomic force microscopy (AFM) is explored. The numerical and structural changes of chromosomes in human breast cells (MCF-10A), moderately malignant breast cells (MCF-7) and highly malignant breast cells (MDA-MB-231) were observed and analyzed by AFM. Meanwhile, the nuclei, cytoskeleton and cell mechanics of the three kinds of cells were also investigated. The results showed the differences in CIN between the benign and cancer cells. Also, the degree of structural CIN increased with enhanced malignancy of cancer cells. This was also demonstrated by calculating the probability of micronucleus formation in these three kinds of cells. Meanwhile, we found that the area of the nucleus was related to the number of chromosomes in the nucleus. In addition, reduced or even aggregated actin fibers led to decreased elasticities in MCF-7 and MDA-MB-231 cells. It was found that the rearrangement of actin fibers would affect the nucleus, and then lead to wrong mitosis and CIN. Using AFM to detect chromosomal changes in cells with different malignancy degrees provides a new detection method for the study of cell carcinogenesis with a perspective for targeted therapy of cancer.
Disclosed is a biomineralizer and a preparation method therefor. The biomineralizer comprises a complex formed by nucleic acid and amorphous calcium phosphate nanoparticles. Also disclosed is a use of the biomineralizer or a collagen fiber product treated with the biomineralizer for treating patients having bone-related diseases or syndromes or for improving bone conditions of patients. The present invention also relates to a method of using the biomineralizer to induce biomimetic mineralization of collagen fibers or to prepare mineralized collagen fiber products. The biomineralizer can also be used as a nucleic acid delivery or transfection system. The biomineralizer is applied to in vitro rapid biomimetic mineralization of collagen fibers and can be used for treating or preventing bone diseases, bone damage, etc., or to enhance bone regeneration, differentiation, and repair.