anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a transcutaneous absorbefacient having excellent absorbefacient effect of drug active component and satisfiable safety and feeling to the skin, by using an anionic surfactant and a nonionic surfactant free from nitrogen atom in the molecule as active components. CONSTITUTION:The objective agent contains one or more kinds of anionic surfactants (e.g. fatty acid soap, ether carboxylic acid and its salt, alkylsulfonic acid salt and sulfosuccinic acid salt) and one or more kinds of nonionic surfactants free from nitrogen atom in the molecule (e.g. sorbitan monooleate and sorbitan monoisostearate) as active components. The drug active component to increase its activity by the use of the above transcutaneous absorbefacient is e.g. predonisolone, indomethacin and chlorpheniramine. The drug active component can be quickly absorbed through the skin by mixing with the absorbefacient and applying to the skin.
BACKGROUND: Sarcopenia is a leading cause of functional decline, loss of independence, premature mortality, and frailty in older adults. Reducing and breaking up sedentary behaviour is associated with positive sarcopenia and frailty outcomes. This study aimed to explore the acceptability, engagement and experiences of a remotely delivered sedentary behaviour intervention to improve sarcopenia and independent living in older adults with frailty.
METHODS: This was a mixed-methods study. In-depth qualitative semi-structed interviews were conducted with a subset (N = 15) of participants with frailty (aged 74 ± 6 years) who had participated in the Frail-LESS (LEss Sitting and Sarcopenia in Frail older adults) intervention aimed at reducing sedentary behaviour. The interviews explored acceptability of the intervention overall and its individual components (a psychoeducation workbook, wrist-worn activity tracker, health coaching, online peer support and tailored feedback on sitting, standing and stepping). Process evaluation questionnaires with closed and scaled questions explored intervention engagement, fidelity and experiences.
RESULTS: Overall acceptability of the intervention was good with most participants perceiving the intervention to have supported them in reducing and/or breaking up their sedentary behaviour. The wrist-worn activity tracker and health coaching appeared to be the most acceptable and useful components, with high levels of engagement. There was attendance at 104 of 150 health coaching sessions offered and 92% of participants reported using the wrist-worn activity tracker. There was a mixed response regarding acceptability of, and engagement with, the psychoeducation workbook, tailored feedback, and online peer support.
CONCLUSIONS: The Frail-LESS intervention had good levels of acceptability and engagement for some components. The findings of the study can inform modifications to the intervention to optimise acceptability and engagement in a future definitive randomised controlled trial.
TRIAL REGISTRATION: The trial was registered with ISRCTN (number ISRCTN17158017).
Toxoplasmosis is a globally significant disease that poses a severe threat to immunocompromised individuals, especially in Brazil, where a high prevalence of virulent and atypical strains of Toxoplasma gondii is observed. In 1998, the EGS strain, exhibiting a unique infection phenotype, was isolated in Brazil, adding to the complexity of strain diversity. The P2X7 receptor is critical in inflammation and controlling intracellular microorganisms such as T. gondii. However, its genetic variability can result in receptor dysfunction, potentially worsening susceptibility. This study investigates the role of the P2X7 receptor during acute infection induced by the EGS atypical strain, offering insight into the mechanisms of T. gondii infection in this context. We infected the female C57BL/6 (WT) or P2X7 knockout (P2X7-/-) by gavage. The EGS infection causes intestinal inflammation. The P2X7-/- mice presented higher parasite load in the intestine, spleen, and liver. The absence of the P2X7 receptor disrupts inflammatory cell balance by reducing NLRP3, IL-1β, and Foxp3 expression while increasing IFN-γ expression and production in the intestine. In the liver, P2X7-/- animals demonstrate diminished inflammatory infiltrate within the portal and lobular regions concurrent with an enlargement of the spleen. In conclusion, the infection of mice with the EGS strain elicited immune alterations, leading to acute inflammation and cytokine dysregulation, while the P2X7 receptor conferred protection against parasitic proliferation across multiple organs.
The invention relates to improvements in apparatus and methods for producing ozone. The apparatus comprises : a differential pressure injector, a means for circulating aqueous fluid through the differential pressure injector and programmable control means. An ozone generator is provided for connection to an oxygen source via an oxygen delivery conduit and a first valve means is located in the oxygen delivery conduit. The ozone generator is fluidly connected to the differential pressure injector via an ozone delivery conduit and second valve means are located in the ozone delivery conduit. Pressure monitoring means are located between the ozone generator and the first valve means for providing a pressure measurement to the control means.; The valve means and the fluid circulation means are operable to create a negative pressure in the oxygen and ozone delivery conduits and the pressure measurement is used by the control means to determine the integrity of the oxygen and ozone delivery conduits.
Participants who will be given both educational video and traditional music therapy 3 times a week for 4 weeks in a row. This group will get Maslach Burnout Inventory, Heart Rate Variability, IgA, T cell regulator, cortisol, and endorphine score evaluated before, in the middle, right after finishing intervention, and 2 weeks after intervention.
After risk notification and education, participants will receive links to two 3-minute immersive Mobile 360° Videos (in which the viewer moves their phone to 'look around' the world of the video) on their smart phones. These videos are intended to influence affective and experiential perceptions of risk. The first video tells an emotional story of the negative effects on an individual's health and family life as they progress from prediabetes to T2DM and develop cardiovascular complications. The second video provides the viewer with a vicarious experience of the changes in vision that occur as diabetic retinopathy develops and worsens.
Systems, methods, and computer-readable media are configured to auto-populate pharmacy SIG codes based on pattern matching model in a pharmacy system. The prescriptions including one or more fields of prescription information in natural language are received in the system. The prescription information can be parsed according to rule-based pattern matching model. The parsed prescription information can be mapped to a token SIG using rule-based pattern matching model dictionaries. A prescription SIG code based on each of the token SIG can be generated. A confidence value of the prescription SIG code based on character coverage of the prescription can be calculated.
Patients will have lignocaine nebulization by using 3 ml of lignocaine 2%, with O2 flow rate 10 l/min to deliver 60 mg lignocaine, of which about 25% is absorbed, and patients were encouraged to inhale deeply to facilitate further delivery of the anesthetic in their airway. After finishing the nebulization setting the patient will be asked about facial, nasal, and oral numbness if no numbness, the patient will have another nebulization setting.
The invention provides a preparation method of a saussurea involucrata ferment, which comprises the following steps. Providing a fermentation feedstock comprising saussurea involucrata. Providing a fermentation broth, wherein the fermentation broth comprises saccharomycetes. And (3) performing a fermentation step, namely mixing fermentation raw materials and fermentation bacterial liquid to obtain a mixture, and culturing the mixture at a fermentation temperature for a fermentation time to obtain a fermented product. Removing solid components of the fermented product to obtain herba Saussureae Involueratae fermented product. Therefore, the effective components of the saussurea involucrata can be effectively extracted and the activity of the effective components is maintained, so that the loss of the effective components and the harm of an organic solvent caused by the traditional extraction method are avoided. In addition, the invention also provides a composition for improving skin condition, which comprises the saussurea involucrata fermentation product.
Parents will be sent links each month directing them to BBC Tiny Happy People content via SMS text message using the secure service FireText. This content will be aimed at supporting language development. Parents will be asked to watch the video content and incorporate it into their parenting practices. The intervention will start when infants are aged 4-9 months and conclude when they are 18 months with a follow up to 24 months where time permits.
All 34 human blood group systems have at least two antithetical antigens and are of potential relevance during pregnancy and transfusion. Fortunately for every day routine practice, immunizations to foreign antigens are rare. Still, incompatibilities may occur in all blood group systems and will then require typing for the respective blood group antigens.

Blood genotyping evolved as the method of choice, in cases when typing reagents are commercially unavailable, or blood is inaccessible (foetus). In databases, most entries of blood group genes lack representative polymorphism (e.g. number of alleles). Moreover, many blood group antigens are insufficiently described in their intronic and inter-genetic sequences. This is true for results of unequal crossing-overs, gene-conversions and large insertions/deletions between highly homologous genes, especially within the blood group systems of Rhesus, e.g. RhD/RhCE and MN/Ss, respectively. Only Whole Genome Sequencing (WGS) allows for resolution of both problems: it delivers the whole blood group genome of an individual, and simultaneously recognizes new blood group alleles, or haplotypes. This request for ethical approval wants to test this assumption.

The antigenic determinants U- and Stones(a)+ of the blood group system MNSs still lack full genetic description and will serve as challenging examples for the description of new alleles (haplotypes) caused by large ins/del mutations of the two highly homologous genes GYPA and B. Genomic DNA of 2 U- samples were both provided as blinded reference material from New York and Vienna blood centres, respectively. Both donors are lost for follow up, and although there is no documented evidence for refusal of the respective donors to use their material in research projects, samples still lack informed consent. Additional reference samples (n max=4), and samples with suspected Stones(a)+ (n max=4) will be recruited from Zurich blood donors with informed consent, only.
The use of mismatch repair (MMR) defective antibody producer cells offers a method to generate subclone variants with elevated protein production such as antibodies. Using MMR defective cells and animals, new cell lines and animal varieties with novel and useful properties such as enhanced protein production can be generated more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within host cells to alter endogenous genes that can yield increased titer levels of protein production. By employing this method, two genes were discovered whose suppressed expression is associated with enhanced antibody production. Suppressed expression of these genes by a variety of methods leads to increased antibody production for manufacturing as well as strategies for modulating antibody production in immunological disorders. Moreover, the suppression of these two genes in host cells can be useful for generating universal high titer protein production lines.
The present invention relates to an atopy treating cosmetic composition containing high purity catechin. By purifying catechin having antioxidant, anti-inflammatory, and immunoregulatory functions at high purity of 95% (w/w) or greater, powdery catechin in which impurities are removed is obtained. The powdery catechin is added to and dissolved in an extract which is obtained by extracting lonicer aflower, Artemisia capillaris Thunberg, Houttuynia cordata, myrrh, Scutellaria roots, Schizonepeta, licorice, gardenia fruits, forsythia fruits, phellodendron bark, and Lithospermum erythrorhizon with ethanol, water, or a mixture thereof, removing a solvent, and re-extracting the obtained concentrate with 1,3-butyleneglycol. A product obtained therefrom is contained as a main ingredient in the cosmetic composition. It is possible to alleviate pruritus in patients suffering from atopic diseases, and suppress occurrence and persistence of inflammation by providing antibacterial and anti-inflammatory effects. It is possible to prevent skin from being dried, and suppress skin troubles. It is possible to provide a fundamental alleviation effect of atopic diseases by providing an immunomodulatory function.
The present invention discloses novel gonadal peptides with inhibin-like activity. The novel peptides include two gonadal peptides, one consisting of 52 amino acids, the other consisting of 92 amino acids. Both of these peptides were initially isolated from human seminal plasma. Both have now been chemically synthesized. The novel peptides are designated as alpha-inhibin-52 and alpha-inhibin-92. Sequence analyses show that the NH 2  -terminal 31 amino acids of alpha-inhibin-52 are identical to the structure of the 31 amino acid inhibin-like peptide previously reported by Ramasharma, et al. (1984). Sequence analyses also show that the COOH-terminal 52 amino acids of alpha-inhibin-92 are identical to the structure of alpha-inhibin-52. The amino acid sequence of alpha-inhibin-92 is: ##STR1## .
Temperature control in severe acute brain injury (SABI) is a key component of acute management. This manuscript delves into the complex role of temperature management in SABI, encompassing conditions like traumatic brain injury (TBI), acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), and hypoxemic/ischemic brain injury following cardiac arrest. Fever is a common complication in SABI and is linked to worse neurological outcomes due to increased inflammatory responses and intracranial pressure (ICP). Temperature management, particularly hypothermic temperature control (HTC), appears to mitigate these adverse effects primarily by reducing cerebral metabolic demand and dampening inflammatory pathways. However, the effectiveness of HTC varies across different SABI conditions. In the context of post-cardiac arrest, the impact of HTC on neurological outcomes has shown inconsistent results. In cases of TBI, HTC seems promising for reducing ICP, but its influence on long-term outcomes remains uncertain. For AIS, clinical trials have yet to conclusively demonstrate the benefits of HTC, despite encouraging preclinical evidence. This variability in efficacy is also observed in ICH, aSAH, bacterial meningitis, and status epilepticus. In pediatric and neonatal populations, while HTC shows significant benefits in hypoxic-ischemic encephalopathy, its effectiveness in other brain injuries is mixed. Although the theoretical basis for employing temperature control, especially HTC, is strong, the clinical outcomes differ among various SABI subtypes. The current consensus indicates that fever prevention is beneficial across the board, but the application and effectiveness of HTC are more nuanced, underscoring the need for further research to establish optimal temperature management strategies. Here we provide an overview of the clinical evidence surrounding the use of temperature control in various types of SABI.
N-Methyl-2-pyrrolidone (NMP) is a small molecule acetyl-lysine mimetic compound with potent (low micromolar range) immunomodulatory and direct anti-myeloma activity attributable to BETbromodomain inhibition at higher concentrations. NMP is nontoxic, stable and already in use as a solvent in biomedical applications. It has been the subject of numerous toxicity studies in humans and been demonstrated to have few adverse effects. The study is proposing an empiric starting dose of 50mg daily, 50% of that seen in healthy volunteers with no observable toxicity. Dose escalation will follow a rule based on accelerated trial design in order to minimise the number of patients treated at sub-therapeutic doses and minimise the length of the study. During the accelerated dose-escalation phase, one patient will be entered per cohort with a dose escalation increment of 100%, with up to 6 dose escalation and up to two dose de-escalation levels.The accelerated phase ends when one patient experiences DLT during the first cycle of treatment or when a total of two patients have experienced moderate toxicity during the first cycle of treatment regardless of the dose level; or the most recent patient has been treated at the highest dose level in the first cycle. If 1 patient experiences a DLT in the first cycle at any dose level, the cohort will be further expanded to a total of 6 patients treated at the same dose level. The maximum tolerated dose (MTD) in the study will be defined as the highest dose in which the incidence of DLT was less than 33%.
An image filing method includes the following steps. A plurality of document is scanned in sequence to generate a plurality of scan image data. A sheet form is searched from the image scan data. When there are M sheet forms searched from the image scan data, the image scan data are divided into M groups, and the sheet form is set up in each home page of M groups. M files are set up according to the M groups. M is an integral larger than 1.
After a woman gives birth, she will often feel anxious, depressed, or upset. For most women, these feelings go away within a week of giving birth, but for some, postpartum depression (PPD) can develop. PPD involves long-term, more severe feelings of anxiety, depression, and despair that impair normal functioning. Untreated PPD threatens both the mental health of mothers and the development of their infants, but many cases go untreated. This may be because of the stigma of mental health treatment, limited availability of programs, cost of treatment, or difficulty finding the time to schedule trips out of the home. Treatment through a Web-based program addresses all these concerns by providing a private, cost-efficient program available anywhere with computer access. This study will develop and test a Web-based version of cognitive behavioral therapy (CBT) to treat women with PPD to determine its feasibility and acceptability.

Participation in this study will last 3 months. All participants will be offered a Web-based version of CBT for PPD. The CBT program will include guided behavioral strategies for dealing with depression, online videos of women who have used these strategies, Web forums in which participants can ask questions of peers and experts, and periodic phone coaching. The program will last 6 weeks. All participants will complete assessments at baseline, post-treatment, and 3-month follow-up. Safety monitoring questionnaires will also be completed at Weeks 2 and 4 of treatment. Assessments will include clinical interviews and questionnaires related to the following: health; depression; demographics; maternal skills, stress, and self-efficacy; Internet use, experience, and self-efficacy; behavioral self-efficacy; and program acceptability.
Humans are fascinated by the bipedal locomotor capacities at both ends of the athletic spectrum-sprinting speed and endurance. Some of the more popular field (eg, soccer, rugby, and lacrosse) and court (eg, basketball, tennis, and netball) sports utilize mixed energy systems requiring an interplay of both maximal sprinting speed (MSS) and maximal aerobic speed (MAS) to meet the high-intensity running demands of varying frequency, duration, intensity, and recovery. Recently, these locomotor capacities have been considered in combination to produce what is called the anaerobic speed reserve (ASR) as part of the locomotor profile concept (MSS, MAS, and ASR). The purpose of this narrative review is to (1) provide an overview of the locomotor profile concept; (2) review the assessment methods for estimating MSS, MAS, and ASR; (3) examine the age-, sex-, and maturity-associated variations in MSS, MAS, and ASR; (4) examine the trainability of MSS, MAS, and ASR in youth athletes; and (5) conclude with the practical applications using principles of long-term athlete development for training the locomotor profile in youth field and court sport athletes. Based on the available data in young male athletes, MSS, MAS, and ASR generally increase with age and across maturity groups and are trainable. Overall, decisions on training need to consider the sport demands, current fitness and maturity status, and targeted training adaptation sought.
The LNSOM-treated group will include 12 children with idiopathic CAS. The pre-treatment assessment is aimed at evaluating the baseline speech and language level and at the treatment planning. None of the SLTs treating this group are PROMPT trained. According to the standard care methods used in Italy, the intervention consists of a linguistic and articulatory approach that includes auditory discrimination of phonemic categories at the syllable and word level and non-speech oral motor exercises. Receptive and expressive lexicon and morphosyntax are targeted depending on the children's linguistic profile.Differently from the PROMPT, selection of speech sounds to be targeted, is based on developmental speech sounds acquisition rather than motor criteria. According to this treatment approach, the motor goal is usually identified with the placement of the main articulator involved in the production of a speech sound.
The invention relates to medical microbiology and can be used for producing vaccine preparations. A method for preparing a conjugate Haemophilus B-type vaccine is proposed. The method comprises culturing Haemophilus influenzae B-type "GKPM-Obolensk" B-7884 strain in a liquid nutrient medium supplemented with ribose, inactivating the culture by heating to 55±5°С and maintaining at this temperature for 15±3 minutes, separating the biomass using a centrifuge and isolating polyribosylribitol phosphate (PRP) by precipitation with a 10% solution of cetyltrimethylammonium bromide (CTAB). The method further comprises the steps of concentration, purification, clarification, activation of PRP and mixing thereof with tetanus toxoid. The substance produced is then purified and sterilised, pharmaceutically acceptable excipients are added thereto, and it is dispensed and freeze-dried. The method provides for an increased yield of the target product.