anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: The management of procedural pain in pediatric patients under 1 year old is crucial but often inadequately addressed in clinical practice. Despite proven evidence-based interventions like skin-to-skin contact, sweet solutions, and breastfeeding, their implementation remains sporadic. This systematic review aims to uncover the barriers and facilitators to adopting these interventions, leveraging the Consolidated Framework for Implementation Research (CFIR) to provide a structured analysis.
METHODS: This review will examine primary studies identifying barriers or facilitators to the use of procedural pain treatments in pediatric patients under 1 year old, imposing no restrictions on the publication year or language. A thorough search will cover databases such as MEDLINE (Ovid), Embase, CINAHL, PsycINFO, Web of Science, and Scopus. The Mixed Methods Appraisal Tool (MMAT) will be utilized for quality assessment. The CFIR framework will serve to categorize and analyze the identified barriers and facilitators, using narrative synthesis for data integration.
DISCUSSION: Applying the CFIR framework allows for a comprehensive and systematic review of the factors influencing the implementation of procedural pain management strategies in pediatric care. By identifying key barriers and facilitators through this lens, the review will guide the development of targeted interventions aimed at enhancing the adoption of evidence-based pain treatments. Such strategic interventions are essential for bridging the gap between research findings and clinical practice, potentially improving the effectiveness and efficiency of pain management for pediatric patients.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42022322319.
BACKGROUND: Neonatal sepsis is responsible for significant morbidity and mortality worldwide. Its accurate and timely diagnosis is hindered by vague symptoms and the urgent necessity for early antibiotic intervention. The gold standard for diagnosing the condition is the identification of a pathogenic organism from normally sterile sites via laboratory testing. However, this method is resource-intensive and cannot be conducted continuously.
OBJECTIVE: This study aimed to predict the onset of late-onset sepsis (LOS) with good diagnostic value as early as possible using non-invasive biosignal measurements from neonatal intensive care unit (NICU) monitors.
METHODS: In this prospective multicenter study, we developed a multimodal machine learning algorithm based on a convolutional neural network (CNN) structure that uses the power spectral density (PSD) of recorded biosignals to predict the onset of LOS. This approach aimed to discern LOS-related pathogenic spectral signatures without labor-intensive manual artifact removal.
RESULTS: The model achieved an area under the receiver operating characteristic score of 0.810 (95 % CI 0.698-0.922) on the validation dataset. With an optimal operating point, LOS detection had 83 % sensitivity and 73 % specificity. The median early detection was 44 h before clinical suspicion. The results highlighted the additive importance of electrocardiogram and respiratory impedance (RESP) signals in improving predictive accuracy. According to a more detailed analysis, the predictive power arose from the morphology of the electrocardiogram's R-wave and sudden changes in the RESP signal.
CONCLUSION: Raw biosignals from NICU monitors, in conjunction with PSD transformation, as input to the CNN, can provide state-of-the-art prediction performance for LOS without the need for artifact removal. To the knowledge of the authors, this is the first study to highlight the independent and additive predictive potential of electrocardiogram R-wave morphology and concurrent, sudden changes in the RESP waveform in predicting the onset of LOS using non-invasive biosignals.
Conventional SLV and complementary with DLV when necessary. When SLV was initiated, the patient was ventilated with left lung. FiO2 of 1.0, tidal volume of 6ml/kg, respiratory rate of 16-24 bpm, PEEP of 5-10 cmH2O. The right lung was totally collapsed. If the SpO2 decreased lower than 90%, DLV was started and the operation was paused until the SpO2 increased to 100%. Then the operation was restarted.
During endoscopic examinations, especially during those performed via oral insertion of endoscopes, an oral bite is used to protect the examination instruments and patients. During sedated endoscopic examinations, the patients are under influence of anesthetics. Upper airway obstruction often occurred due to respiratory depression and airway collapse resulting in desaturation. Airway management with high percentage oxygen, jaw thrust, or insertion of nasal airways by trained anesthetic personnel is required during upper airway obstruction emergencies. Nasal airway is invasive and causes nasal bleeding, sinusitis and other problems. Jaw thrust and bag-mask ventilation requires training and is a burden to anesthetic personnel to perform. Oxygenation and capnography are important ventilatory monitors during sedative procedures. These are often influenced by open mouth breathing during upper gastrointestinal endoscopic examinations making oxygenation and capnographic measurements unreliable. In this study, we group the patients into A group using standard of care, B group using mandibular advancement oral bite and C group using high-flow nasal cannulas. After anesthetic induction, gastric endoscopy will be performed. Oxygenation, end-tidal carbon dioxide, and degree of upper airway obstruction will be evaluated and recorded. Differences between the groups will be evaluated.
The present invention provides bioenergetic healthcare toothpaste microparticles, which are characterized in that they are used to produce bioenergetic healthcare toothpaste capable of emitting far-infrared rays. The bioenergetic healthcare toothpaste microparticles are composed of at least one main core part and an active protective layer covering the outer portion of the main core part, and have a particle structure that has an equivalent diameter in the range of 0.1 [mu]m to 500 [mu]m. The main core part accommodates at least one or a plurality of organic microparticles, and at least one or a plurality of inorganic microparticles. The organic microparticle is a non-solid particle that has a first accommodating space inside. The first accommodating space at least accommodates propolis microparticles containing propolis extract, turmeric microparticles containing turmeric extract, tea tree essential oil microparticles containing tea tree essential oil, and lecithin. The inorganic microparticle is non-solid particle that has a second accommodating space inside. The second accommodating space at least accommodates bamboo charcoal microparticles and ore microparticles. When the bioenergetic healthcare toothpaste made of the bioenergetic healthcare toothpaste microparticles is used, the far-infrared rays emitted from the ore microparticles can have the effects of anti-inflammatory, sedative, wound healing, and pain relief.
This study examined the sustained and moderating effects of a behavioural sleep intervention for autistic children in a randomised controlled trial. Autistic children (5-13 years) with sleep problems were randomised to the Sleeping Sound intervention or Treatment as Usual (TAU). At 12-month follow-up (n = 150), caregivers of children in the Sleeping Sound group reported greater reduction in child sleep problems compared to TAU (p < .001, effect size: - 0.4). The long-term benefits of the intervention were greater for children taking sleep medication, children of parents who were not experiencing psychological distress, and children with greater autism severity. The Sleeping Sound intervention demonstrated sustained improvements in child sleep. Identified moderators may inform treatment by indicating which subgroups may benefit from further support.
A woman in her early 40s presented with right-side chest pain radiating to the ipsilateral shoulder coinciding with her menstrual periods. She complained of worsening dysmenorrhoea over the preceding 6 months. Chest radiograph was notable for pneumothorax. Conservative management through hormonal suppression was initially pursued but proved ineffective for preventing recurrence. The patient ultimately underwent video-assisted diagnostic thoracoscopic surgery through robotic approach; intraoperative findings confirmed the presence of endometrial deposits of the diaphragm, confirming the cause of the patient's catamenial pneumothorax. The patient recovered well and was started on a gonadotropin-releasing hormone antagonist 3 weeks following her operation.
Sarcomatoid mesothelioma is difficult to differentiate from other mesotheliomas. Here, we describe the case of a man in his early 80s with sarcomatoid mesothelioma and a history of asbestos exposure. He initially presented with right-sided chest pain and was examined. Right-sided pleural effusion was detected; therefore, he was hospitalised. Based on the observed pleural effusion and biopsy result, the presence of a malignant tumour was excluded; hence, he was diagnosed with benign asbestos pleurisy. He subsequently developed left-sided pleural effusion, masses and lung nodules, and died 9.5 months after the initial examination. A definitive diagnosis of sarcomatoid mesothelioma with rapid systemic progression was established after detailed investigations using autopsy specimens. This rare case of mesothelioma-without p16 deletion (detected using fluorescence in situ hybridisation)-presented differently from the usual sarcomatoid mesothelioma.
Patients receive regorafenib PO QD on days 1-21, nivolumab IV over 30 minutes Q2W, and ipilimumab IV over 30 minutes Q6W. Cycles repeat every 28 day for up to 2 years in the absence of disease progression or unacceptable toxicity.
A sanitation system may include a sink, a sanitation material dispenser for dispensing material such as soap, and a dryer for either dispensing dryer material such as paper towels or providing heated air. An electronic device may be in communication with one or more of these items, and a sanitation module may operate on the sanitation system. The sanitation module may time a sanitation activity for the sanitation system, such as hand washing. Content may be displayed on the electronic device, and the content may serve to engage or distract the user. The electronic device may be able to identify the individual user and customize the content. The sanitation module may time the sanitation procedure and may accordingly promote a minimum time spent on the sanitation activity. The sanitation system may also be used for monitoring either the sanitation material or the dryer material and automatically order new material when the material is low.
The invention relates to a method for inhibiting Dcf1 The application of the expression of the gene in preparing the medicine for treating obesity. The invention is based on the use of wild type (as a control) and dcf1 two mice were knocked out and detected by behavioural analysis dcf1 The loss of (a) results in a reduction in weight and diet of the mice. Then detecting the down regulation of the NPY protein by Western blotting and immunohistochemistry; thereafter prove dcf1 Upstream of the NPY. Final ATP detection with kit dcf1 After knockout, mouse hypothalamic tissue and primary cells were high in ATP levels. Overexpression in 293T cells respectively dcf1 And NPY, both cause a decrease in cellular ATP levels. Therefore, the temperature of the molten metal is controlled, dcf1 has important role in energy balance, and can provide a novel method for treating obesity.
In this arm, 50 patients with extensive-stage small cell lung cancer or relapsed within more than 6 months after SCLC radical treatment will receive 4 circles of toripalimab combined with platinum-based doublet chemotherapy. Then patients received maintenance treatment with toripalimab until the disease progressed.
Hypothermia during obstetric spinal anaesthesia is a common and important problem, yet temperature monitoring is often not performed due to the lack of a suitable, cost-effective monitor. This study aimed to compare a noninvasive core temperature monitor with two readily available peripheral temperature monitors during obstetric spinal anaesthesia. We undertook a prospective observational study including elective and emergency caesarean deliveries, to determine the agreement between affordable reusable surface temperature monitors (Welch Allyn SureTemp® Plus oral thermometer and the Braun 3-in-1 No Touch infrared thermometer) and the Dräger T-core© (using dual-sensor heat flux technology), in detecting thermoregulatory changes during obstetric spinal anaesthesia. Predetermined clinically relevant limits of agreement (LOA) were set at ± 0.5 °C. We included 166 patients in our analysis. Hypothermia (heat flux temperature < 36 °C) occurred in 67% (95% CI 49 to 78%). There was poor agreement between devices. In the Bland-Altman analysis, LOA for the heat flux monitor vs. oral thermometer were 1.8 °C (CI 1.7 to 2.0 °C; bias 0.5 °C), for heat flux monitor vs. infrared thermometer LOA were 2.3 °C (CI 2.1 to 2.4 °C; bias 0.4 °C) and for infrared vs. oral thermometer, LOA were 2.0 °C (CI 1.9 to 2.2 °C; bias 0.1 °C). Error grid analysis highlighted a large amount of clinical disagreement between methods. While monitoring of core temperature during obstetric spinal anaesthesia is clinically important, agreement between monitors was below clinically acceptable limits. Future research with gold-standard temperature monitors and exploration of causes of sensor divergence is needed.
Chronic cough, which lasts for more than 8 weeks, is one of the most common complaints requiring medical attention, and patients suffer from a huge socioeconomic burden and a marked decrement in quality of life. Animal models can mimic the complex pathophysiology of the cough and are important tools for cough research. The detection of cough sensitivity and airway inflammation is of great significance for studying the complex pathological mechanism of cough. This article describes the measurement of cough using a noninvasive and real-time whole-body plethysmography (WBP) system and the normative procedures for harvesting tissue samples (including blood, lung, spleen, and trachea) of mice. It introduces some methods to assess airway inflammation, including pathological changes in hematoxylin and eosin (HE)-stained lung and trachea sections, the total protein concentration, the uric acid concentration, and the lactate dehydrogenase (LDH) activity in the supernatant of bronchoalveolar lavage fluid (BALF), and the leukocytes and differential cell counts of BALF. These methods are reproducible and serve as valuable tools to study the complex pathophysiology of cough.
This is prospective and randomized controlled trial (RCT) with 2 arms and blinded outcome assessments. Forty-six moderate or severe patients with asthma under optimized medication will be randomly assigned (computer-generated) into either Control Group (CG) or Intervention Group (IG). Both groups will receive similar educational program. However, only the IG will be submitted to the behavioral intervention through physical activity counseling program combined with a monitoring-and-feedback tool aiming to increase physical activity levels (total of 8 weekly goal-setting consultation, face-to-face, each lasting 40 minutes). Before and after the interventions, clinical control of asthma, physical activity levels, health-related quality of life, asthma exacerbation, levels of anxiety and depression symptoms and anthropometric indices will be assessed. Data about onset of asthma, comorbidities, lung function and asthma medication will be collected from the patient's medical record. The data normality will be analyzed by Kolmogorov-Smirnov, and a two-way ANOVA with repeated measures with appropriate post hoc of Holm-sidak will be used to compare inter and intra-groups differences. The significance level will be set to 5% for all tests.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to surgery, and can be used for optimising pancreatonecrosis treatment. The method involves a traditional conventional therapy of the disease, as well as plasmapheresis sessions. It is added with the daily introduction of antioxidants by the following regimen: in the morning intravenous infusions of 0.5 % vinpocetine 6.0ml in physiologic saline 20ml or 40ml, in the afternoon intramuscular injections of 2.5 % thiotriazoline 4.0ml, in the evening intravenous infusions of 4 % glutargine 10.0ml in physiologic saline 150ml. Besides, daily sessions of low-frequency magnetic infrared laser therapy with the MILTa apparatus are carried out in projection points of a pancreas for 5 minutes of irradiation in each point. ^ EFFECT: method provides effective pancreatonecrosis treatment, prevents developing of necrotic suppurative complications even without prescribing protease inhibitors, the method can be used both for the purpose of the conservative therapy of the disease, and for the purpose of preoperative preparation and postoperative regimen management. ^ 2 ex, 1 tbl
The present invention relates to a system and method for collecting and analysing the properties of foodstuffs bought by a consumer(s), such as information concerning nutrients, and for transmitting it to the consumer in order that he or she can make selections of food contributing to and maintaining his or her health, and for enabling the use of the collected history information for research purposes both for individuals and population groups. The system of the invention comprises a product (20) provided with a unique identifier, which is read using a reading device (21) and which is further transmitted to a cash system (22). In the system of the invention, arranged between the reading device (21) and the cash system (22) is a specific distribution cable (28) by means of which the information is transmitted also to a nutrient server (23). The nutrient server retrieves the nutrient compositions of the purchases from a database (24). The calculated results are presented on a web server (25) to which a client can connect using any terminal device (27) connected to the Internet. The properties of the purchased products are saved to the database (29) for each consumer specifically.
PURPOSE:To obtain the subject medicine containing a specific compound as an active ingredient, having remarkable arterialization inhibiting action, useful in treatment and prevention for diseases accompanying abnormal accentuation of arterialization such as cancer, chronic inflammation or arteriosclerosis and having low toxicity and being safe. CONSTITUTION:The objective medicine contains a compound of the formula [R1 and R2 are H, 1-6C alkyl or R3CO (R3 is H or 1-6C alkyl] as an active ingredient. Radisicol which is a compound of the formula wherein R1 and R2 are simultaneously H is obtained by subjecting, e.g. Penicillium luteo-aurantiumu Smith (IFO-8176) to stationary culture at 27 deg.C for 21 day. The compound other than radisicol expressed by the formula is preferably obtained by alkylating a hydroxyl group of radisicol with an alkyl halide or esterifying the hydroxyl group using a carboxylic acid, its acid chloride or acid anhydride. The compound of the formula is preferably administered in several portions in an amount of 50-300mg/adult daily in the case of oral administration.
PURPOSE:To obtain the titled compound useful as an antithrobotic drug, by condensing a benzothiazepine derivative with a dialkylaminoethyl halogenide. CONSTITUTION:A benzothiazepine derivative shown by the formula I (R<1> is lower lakyl) is condensed with a compound shown by the formula II (R<2> and R<3> are lower alkyl; X is halogen), and, if necessary, the condensation product is converted into an acid addition salt, to give the desired compound shown by the formula III or its acid addition salt. The reaction is carried out in a proper solvent in the presence of a base (e.g. NaOH) at 0-100 deg.C, preferably at 20-70 deg.C. The compound shown by the formula II can be obtained by hydrolyzing a novel benzothiazepine derivative shown by the formula IV (R<4> is lower aklanoyl). The compound shown by the formula IV can be obtained by reacting a compound shown by the formula V with a reactive derivative of a carboxylic acid shown by the formula R<4>OH in the presence of a compound shown by the formula (R<5>)2RO(R<5> is lower alkyl).
FIELD: medicinal cosmetology and dermatology. SUBSTANCE: preparation on base of tea tree oil contains gel-former, moistener, conserving agent, and water. As a gel-former, it contains a substance of polysaccharide origin separated from group of hydroxycellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, hydroxypropylguar, xanthane resin, corragenan, and chitosan. As a conserving agent, preparation includes methylparabene or propylparabene. All components are used in determined quantitative ratio. The preparation is not toxic, easy in application, and has no side effects. EFFECT: protecting function of skin without disturbance of tissue respiration. 2 cl, 7 ex
Crystalline Irbestan Form A having a structure such that the ratio of length/width is between 1:1 and 10:1, processes for its preparation, and pharmaceutical compositions containing it. Irbestan is of formula (I).   Its preparation, and the separation of Form A are described in EP454511 and EP708103.  Known crystals of this material are needle-shaped, but the new crystalline structure preferably has a length/width ratio of 1:1 to 5:1.  This new form is prepared by either of the following methods:   (1) a suspension of crystalline (I) Form A is submitted to at least one period of sonification, and at least one of temperature oscillation, conducted simultaneously or sequentially.  Preferably the heating phase in the temperature oscillation is effected so that 15 - 25% of the crystals dissolve after about 60 minutes.  The cooling phase is preferably carried out at -5 to +20  deg C; (2) Needles of (I) are dissolved in an alcohol, the solution is cooled to a temperature at which, at the given concentration the solution enters a metastable state, and this is then seeded with crystals of the new Form A.  The resulting crystalline suspension is mechanically sheared, the mixture is re-heated to dissolve the fine particles, and the suspension cooled to 5 - 20  deg C and filtered.
Glioblastoma is the prevailing and highly malignant form of primary brain neoplasm with poor prognosis. Exosomes derived from glioblastoma cells act a vital role in malignant progression via regulating tumor microenvironment (TME), exosomal tetraspanin protein family members (TSPANs) are important actors of cell communication in TME. Among all the TSPANs, TSPAN6 exhibited predominantly higher expression levels in comparison to normal tissues. Meanwhile, glioblastoma patients with high level of TSPAN6 had shorter overall survival compared with low level of TSPAN6. Furthermore, TSPAN6 promoted the malignant progression of glioblastoma via promoting the proliferation and metastatic potential of glioblastoma cells. More interestingly, TSPAN6 overexpression in glioblastoma cells promoted the migration of vascular endothelial cell, and exosome secretion inhibitor reversed the migrative ability of vascular endothelial cells enhanced by TSPAN6 overexpressing glioblastoma cells, indicating that TSPAN6 might reinforce angiogenesis via exosomes in TME. Mechanistically, TSPAN6 enhanced the malignant progression of glioblastoma by interacting with CDK5RAP3 and regulating STAT3 signaling pathway. In addition, TSPAN6 overexpression in glioblastoma cells enhanced angiogenesis via regulating TME and STAT3 signaling pathway. Collectively, TSPAN6 has the potential to serve as both a therapeutic target and a prognostic biomarker for the treatment of glioblastoma.