anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The anti-an mic principle, the physiologically active substance or hormone known as physin, and meat extracts for flavouring &c. are extracted from liver, or aqueous solutions or suspensions obtained from liver, or from liver digested by ferments, by treating the material with alcohol of concentration increasing progressively up to 90 per cent and treating the extract soluble in 90 per cent alcohol with acetone.  Liver to be extracted is preferably digested, e.g. with papain, and the liquid product evaporated to a paste to which sufficient alcohol is added to give an alcoholic content of 60 per cent, the mixture being allowed to stand and then filtered.  The precipitate is a meat extract or base for soups, gravies, &c.  To the filtrate is added alcohol sufficient to give a concentration of 90 per cent and filtered, the residue being redissolved in water and again precipitated with 90 per cent alcohol.  This precipitate contains the anti-an mic principle.  The combined filtrate is then freed from alcohol by distillation and taken up in water.  It contains all the physin which may be further concentrated by adding acetone up to 90 per cent.  The filtrates from acetone treatment are evaporated to dryness or small bulk and constitute the final concentrate of physin.  The residue from the acetone treatment is a meat-flavouring extract.  When preparing anti-an mia extract by the known method employing a mixture of alcohol and acid followed by dehydration alcohol for extracting liver after evaporation of the alcohol, the residue is washed with water and contains most of the physin.  This residue may be further treated with acetone as above described.
For elite endurance athletes, the addition of resistance training to habitual endurance training routines generally leads to improved endurance performance. However, this is not always the case, with several individuals failing to respond in the expected manner. This inter-individual variation is likely associated with inherent cellular and molecular charateristics of skeletal muscle. Indeed, responses to resistance training seem to be associated with muscle biological characteristics such as muscle fiber composition and ribosomal content (during the early phase of resistance training).

The study will investigate the association between muscle fibre composition (type I vs type II muscle fiber proportions) / ribosomal content in m. vastus lateralis and the effects of 10 weeks of resistance training on endurance performance in 52 elite cyclists. Half the participants will perform resistance training in addition to their habitual endurance training routines, the other half will perform endurance training-only. Muscle biopsies will be sampled from m. vastus lateralis before and after the first two weeks of the intervention. For muscle fiber composition, the hypothesis is that larger proportions of type II fibers will be associated with more pronounced benefits of resistance training. For ribosomal content, the hypothesis is that higher rRNA content at baseline and larger increases in rRNA content during the initial part of the intervention will be associated with more pronounced benefits of resistance training. No changes are expected in the non-resistance training control group.
PROBLEM TO BE SOLVED: To make decreasable the number of operations and make easily executable correction in a short time by dragging a selected multinodal segment or dot string, and moving one or a plurality of the other multinodal segments or dot string adjacent to the selected multinodal segment or dot string to follow up according to a prescribed tension. SOLUTION: A ROI point formed by a multinodal segment or a connecting point (dot string) is set to plot a closed curve. The spaces of all ROI points forming the closed curve are set to equal spaces. An operator selects an arbitrary ROI point, that is, an operating point by a pointing device, and drags the same to move the operating point in a desired direction. When the operating point is moved, some of the adjacent points are moved together according to the travel amount of the operating point and the moving direction. Then, if the moving direction points to the inside, tension is increased according to the travel amount, and on the contrary, if it points to the outside, tension is decreased according to the travel amount so as to restrain the travel amount of the adjacent point.
PURPOSE: A method and an apparatus for differentiating stem cells using composite waves are provided to quickly differentiate the stem cells into nerve cells. CONSTITUTION: A method for differentiating mesenchymal stem cells into nerve cells comprises a step of simultaneously or sequentially treating the mesenchymal stem cells by an electromagnetic field and sound wave. The mesenchymal stem cells are derived from embryos or adult tissue. The mesenchymal stem cells are derived from bone marrow, fat, umbilical cord blood, or umbilical cord. The differentiated nerve cells are treated by an electromagnetic field and sound wave. A pharmaceutical composition for treating neurological disorders contains the nerve cells.
The invention discloses a medicament for treating water burn. 500 grams of dog skull is burnt to ashes. The medicament can be made into ointment, and the formulation of the medicament is water preferably. A method for preparing the medicament comprises the following steps of: burning the dog skull to ashes in a container, adding a proper amount of fine rice water, stirring uniformly to obtain the medicament, and storing the medicament in a closed space. An application method of the medicament is that the prepared liquid medicament is directly applied on the affected part by using cock feather. The medicament of the invention has the functions of eliminating necrotic tissues, promoting granulation, nursing skin, relieving pain, astringing sores and promoting fast growth of skin cells, and has the advantages of quick response, good curative effect, low price, no scar and an overall effective rate of 98.5 percent when used for treating water burn.
Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.
Two cans (33 cl.) per day of an alcohol-free beer with regular carbohydrates composition.
INTRODUCTION: Housing insecurity is rising among older adults; health researchers know little about how this may impact their cognitive health. We investigated links between foreclosure and older adults' memory and probability of dementia.
METHODS: Using the Health and Retirement Study (2008 to 2018), we fit mixed models comparing the memory and dementia probability scores of 249 older adults who experienced foreclosure (treated) with 15,645 who did not. Baseline covariates included sociodemographics and health. Models were stratified by age group.
RESULTS: Foreclosure was associated with faster memory decline among middle-aged (50 to 64) older adults (-0.007 standard deviations/year, 95% confidence interval: -0.13, -0.001). Compared to average memory decline among middle-aged older adults who were stably housed, foreclosure equated to 3.7 additional years of aging over 10 years. Among those 65+, differences between those who were and were not foreclosed upon were short-lived and less clear, potentially driven by depletion-of-susceptibles bias.
DISCUSSION: Foreclosure may endanger older adults' memory.
HIGHLIGHTS: Housing instability is a key determinant of cognitive aging. We examined foreclosure and levels and changes in memory and dementia probability scores in the US older adult population. Foreclosure was associated with faster memory decline among middle-aged (50 to 64) older adults, equivalent to 3.7 additional years of cognitive aging over 10 years. Foreclosure yielded sharp memory declines and increases in dementia probability among older adults 65 and above. Foreclosure imposes a greater risk for older adults' cognitive decline.
Tablet of LEV at 1,5 mg/kg will be administrated to the participant ; in single dose only one time. The number of tablets of LEV of 50 mg or 10 mg will be adapted according to the weight of the participant.
Medicinal honey: Medicinal honey will be applied to the abutment site immediately after surgery. The healing cap will be placed on the BAHI site. The healing cap is removed on postoperative day 7. Patient is instructed to apply medicinal honey daily to the area for 2 weeks.
Spironolactone 25 mg PO daily for three days. During five days investigators will collect values of plasma creatinine, sodium, potassium, blood ureic nitrogen, vital signs and urinary output.
This is a prospective minimal-risk observational study to collect and analyze EEG data during intraepidermal electrical stimulation in patients receiving general anesthesia (GA) for abdominal surgery. To collect nociception-related EEG signal during GA the investigators designed a standardized Intraepidermal Electrical Stimulation (IES) Protocol. The intensity of the electrical stimulus will be calibrated to each participant perception pre-surgery, with 3 different intensities: sensitivity threshold, mild-pain threshold, and moderate-pain threshold. The IES will be administered several times throughout the surgical procedure: a) At baseline, prior to induction of GA, b) Three minutes after loss of consciousness, c) Five minutes after fentanyl administration and orotracheal intubation, d) Five minutes after first incision and every 20 minutes until the end of the surgery, and f) After surgery ends and before extubation. To standardize the anesthesia management as much as possible, all patients will be attended by a reduced number of anesthesiologists. The hypnosis will be achieved with propofol, while analgesia will be mainly achieved with either fentanyl or remifentanil. EEG will be recorded with a 32-channel high standard equipment. Once the patient arrives to the Post-Anesthesia Care Unit (PACU), the investigators will record the pain reported by the patient using the Numeric Pain Rating Scale every 15 minutes during the first hour, and every 30 minutes until patient is discharged from the PACU. Also, the investigators will both, record opioid administration through the surgery and estimate their effect-site concentration with pharmacokinetic/pharmacodynamic models. Besides, the investigators will measure opioid plasmatic concentrations.
Propofol blood concentrations at steady-state are generally proportional to infusion rates, especially in individual patients. Undesirable effects such as cardiorespiratory depression are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in the infusion rate. An adequate interval (3 minutes to 5 minutes) must be allowed between dose adjustments to allow for and assess the clinical effects.

Shake well before use. Do not use if there is evidence of excessive creaming or aggregation, if large droplets are visible, or if there are other forms of phase separation indicating that the stability of the product has been compromised. Slight creaming, which should disappear after shaking, may be visible upon prolonged standing.

When administering DIPRIVAN by infusion, syringe or volumetric pumps are recommended to provide controlled infusion rates. When infusing DIPRIVAN to patients undergoing magnetic resonance imaging, metered control devices may be utilized if mechanical pumps are impractical.

Changes in vital signs indicating a stress response to surgical stimulation or the emergence from anesthesia may be controlled by the administration of 25 mg (2.5 mL) to 

50 mg (5 mL) incremental boluses and/or by increasing the infusion rate of DIPRIVAN. 

For minor surgical procedures (e.g., body surface) nitrous oxide (60% to 70%) can be combined with a variable rate DIPRIVAN infusion to provide satisfactory anesthesia. With more stimulating surgical procedures (e.g., intra-abdominal), or if supplementation with nitrous oxide is not provided, administration rate(s) of DIPRIVAN and/or opioids should be increased in order to provide adequate anesthesia.

Infusion rates should always be titrated downward in the absence of clinical signs of light anesthesia until a mild response to surgical stimulation is obtained in order to avoid administration of DIPRIVAN at rates higher than are clinically necessary. Generally, rates of 50 mcg/kg/min to 100 mcg/kg/min in adults should be achieved during maintenance in order to optimize recovery times.

Other drugs that cause CNS depression (e.g., sedatives, anesthetics, and opioids) can increase CNS depression induced by propofol. Morphine premedication (0.15 mg/kg) with nitrous oxide 67% in oxygen has been shown to decrease the necessary propofol injection maintenance infusion rate and therapeutic blood concentrations when compared to non-narcotic (lorazepam) premedication.
Nanoplastics (NPs) exposure is usually linked with abnormal inflammation and oxidative stress, which are high-risk triggers of atherosclerosis; however, whether this exposure causes the development of atherosclerosis is vague. Here, we found that PS NPs co-exposure with ox-LDL induces significant accumulation of lipid, as well as oxidative stress and inflammation in RAW264.7 macrophages. Using an ultrasound biomicroscope (UBM), we observed the emergence of atherosclerotic plaques at the aortic arch of apolipoprotein knockout (ApoE-/-) mice after being exposed to PS NPs for three months. Oil-red O and hematoxylin-eosin (H&E) staining at the mice's aortic root also observed the deposition of lipids with plaque formation. Moreover, the development of atherosclerotic disease is associated with disturbances in lipid metabolism and oxidative stress damage in the mice liver. In conclusion, this study provides additional evidence to further understand the possible cardiovascular damage caused by NPs exposure.
Clinical Laboratory Evaluations

Because of its deep red color, hydroxocobalamin has been found to interfere with colorimetric determination of certain laboratory parameters (e.g., clinical chemistry, hematology, coagulation, and urine parameters). In vitro tests indicated that the extent and duration of the interference are dependent on numerous factors such as the dose of hydroxocobalamin, analyte, methodology, analyzer, hydroxocobalamin concentration, and partially on the time between sampling and measurement. 

The data presented in Table 2 is collected from in vitro studies and pharmacokinetic data in healthy volunteers and describes laboratory interference that may be observed following a 5 g dose of hydroxocobalamin. Interference following a 10 g dose can be expected to last up to an additional 24 hours. The extent and duration of interference in cyanide-poisoned patients may differ. In addition, results may vary substantially from one analyzer to another. Be aware of this when reporting and interpreting laboratory results. 

Clinical Methods

Because of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a “blood leak”. This should be considered before hemodialysis is initiated in patients treated with hydroxocobalamin.
PURPOSE:To obtain a coating composition, containing a drug capable of acting through the skin, water-insoluble highly water absorbing resin, water and alcohol as essential ingredients and capable of releasing the drug at an optionally adjustable release rate for a long period. CONSTITUTION:A coating composition obtained by containing a drug capable of acting through the skin, e.g. anti-inflammatory agent, analgesic agent or remedy for cardiopathy, a water-insoluble highly water absorbing resin, e.g. water-acrylic acid-vinyl alcohol copolymer, starch-acrylic acid graft copolymer, etc., particularly preferably the former, water and an alcohol, preferably polyhydric alcohol as essential ingredients. The release rate can be varied by changing the blending ratio of the resin. When the acrylic acid-vinyl alcohol copolymer is used as the resin and PEG-400 is used as the alcohol, a wide gelatinization range can be shown and the release rate can be adjusted within a wide range.
Vitamin D deficiency in relation to bone metabolism and healing has been controversial and not well studied. However, hypovitaminosis has been widely identified within the orthopedic patient population. The current best evidence suggests a lack of data on this important topic. The ability to assess patients for optimum bone healing and metabolism is still in question due to lack of a suitable reliable biomarker and multiple other unknown variables affecting bone metabolism. To compound this effect, popular dermatological precautions in the last 20 to 30 years of avoiding sunlight also have the effect of further reducing serum vitamin D production in the skin. As a proof of concept, we performed a preliminary comparative observational retrospective review of orthopedic patients undergoing fracture and arthrodesis osseous healing to determine how serum vitamin D levels are associated with bone healing along with their confounding comorbidities. Based on our review, the current accepted vitamin D levels (≥20 ng/mL) are low and insufficient for fractures and for arthrodesis osseous healing due to observed high rates (>35%) of delayed unions, and an increased (>90%) in the number of multiple confounding comorbidities affecting bone healing process that are often not mentioned or captured in this type of study in previous literature. Obesity and diabetes are significant contributory risks factors, and the preliminary findings suggest that the current accepted adequate levels may not be enough for osseous healing. These low vitamin D levels appear to affect bone healing and prolong treatment, with worsening trends with diabetes and obesity comorbidities.
Citrobacter rodentium models infection with enteropathogenic Escherichia coli and ulcerative colitis (UC). While C57BL/6 (C57) mice recover, C3H/HeN (C3H) mice succumb to infection, partially due to increased colonic neutrophil elastase activity, also seen in UC patients; however, the underlying cause was unknown. Here, we found that bone marrow, blood, and colonic C57 neutrophils expressed (CD)11bHi and reached the infected colonic lumen, where they underwent productive NETosis. In contrast, while the number of C3H neutrophils increased in the bone marrow, blood, and colon, they remained CD11bLo and got trapped in the submucosa, away from C. rodentium, where they underwent harmful NETosis. CD11bLo neutrophils in C3H mice infected with CRi9, which triggers expression of neutrophil chemoattractants, reached the colonization site, resulting in host survival. UC patient neutrophils also displayed decreased levels of the activation/differentiation markers CD16/CXCR4. These results, suggesting that neutrophil malfunction contributes to exacerbated colitis, provide insight for future therapeutic prospects.
BACKGROUND: Acute lower gastrointestinal bleeding (LGIB) is a common reason for hospital admission. However, the majority resolve spontaneously and only a minority require inpatient intervention. We aimed to describe the epidemiology and aetiology of acute LGIB admissions in our institution. We also aimed to validate the Oakland Score, which can identify patients at low risk of adverse outcome from LGIB, in our population and determine the proportion who could have safely avoided admission.
METHODS: Using the prospective, validated Otago Clinical Audit database (DIVA), we searched for adult patients admitted to Dunedin Hospital with a primary diagnosis of LGIB between January 2013 and December 2020. We retrieved data to calculate the Oakland Score and details of inpatient treatment from the electronic patient record. We excluded patients admitted electively, admissions related to inflammatory bowel disease, and those with upper gastrointestinal bleeding.
RESULTS: We identified 761 patients of which 501 met inclusion criteria (56% male, median age 76 years, 82% NZ European). Overall, 72% were managed with observation or diagnostic endoscopy, 32% received blood products, and 7% required haemostatic intervention to control bleeding. The area under the receiver operating characteristic curve for the Oakland Score was 0.85 (95% CI, 0.81-0.89). A cut-off score of ≤10 predicted a 95% probability of safely avoiding admission. This equates to saving 30 bed-days annually.
CONCLUSION: The majority of patients admitted with LGIB are managed conservatively. The Oakland Score could be used as a stratification tool to safely reduce the admission rate.
The invention discloses two tumor targeting photosensitizers, and preparation methods and applications of the photosensitizers. The photosensitizer HSA-(PpIX)2 is prepared by coupling reaction of HSA and PpIX. With the adoption of modification, the biocompatibility and the photochemical property of PpIX are improved; PpIX has stronger killing effect on a cancer cell; and the fluorescence of protoporphyrin is kept. In addition, HSA-(PpIX)2 can be used for adjusting the yield of active oxygen after loading fullerene derivatives. Vivo experiments of mouse breast cancer models indicate that the photosensitizer can be gathered at a tumor site efficiently due to a special EPR effect of a nanomaterial to realize high-sensitive fluorescent imaging of an in vivo level, so that a tumor is positioned accurately, and the best treatment time is monitored. The 16-day monitoring of the effect of photodynamic therapy shows that the photosensitizer can inhibit the growth of the tumor effectively.
Neutral to mildly acidic externally-applied mastitis control agents comparable to iodophor teat dips in activity can be obtained from the combination of an anionic surfactant (e.g. an aromatic sulfonate or sulfonic acid) and an aminocarboxylic-type chelating agent. A nitroalkanol antibacterial can be included in the composition. The full strength teat dip contains a major amount of water (but less than 98%) and typically includes an emollient, a buffering agent, and a thickener. The anionic surfactant (which is believed to be effective against gram positive mastitis-causing organisms) and the chelating agent appear to cooperate in the pH range above 4 and below 7. The chelating agent is believed to improve the cell wall permeability of the mastitis-causing organisms, even in this pH range.