anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a meilitracen pharmaceutical composition with high security. The meilitracen pharmaceutical composition comprises meilitracen, no more than 0.1% of a compound shown as formula I and no more than 0.1% of a compound shown as formula II. The meilitracen pharmaceutical composition provided by the invention also comprises a certain amount of flupentixol. Commercially available flupentixol and meilitracen tablets may cause adverse effects such as anxiety, dysphoria and agitation which may be related to intermediate and byproduct which are formed in a synthesis process of meilitracen. The intermediate and byproduct are the compounds shown as the formula I and the formula II. The invention provides a method for separation, purification and identification of the compounds shown as the formula I and the formula II. Liquid chromatography is prepared by adding a certain amount of cyclodextrin in a silica gel column, to separate and identify the compounds successfully. The invention provides a preparation method for the compounds shown as the formula I and the formula II. The content of substances causing the adverse effects is greatly reduced in the pharmaceutical composition provided by the invention, so that the drug has higher security and efficacy.
Brain imaging work aimed at increased classification of dyslexia has underscored an important relationship between anterior (i.e., the inferior frontal gyrus; IFG) and posterior (i.e., superior temporal gyrus and supramarginal gyrus) brain regions. The extent to which the three components of the inferior frontal gyrus, namely the pars orbitalis, triangularis, and opercularis, are differentially related to the posterior regions, namely the superior temporal gyrus and supramarginal gyrus, needs further elucidation. Information about the nature of the anterior-posterior connections would facilitate our understanding of the neural underpinnings associated with dyslexia. Adult participants (N = 38; 16 with dyslexia) took part in an MRI study, whereby high-resolution structural scans were obtained. Volumetric asymmetry of the three regions of the IFG, the superior temporal gyrus, and the supramarginal gyrus was extracted. Significant differences were found for each of the three IFG regions, such that skilled readers had a greater leftward asymmetry of the orbitalis and triangularis, and greater rightward asymmetry of the opercularis, when compared to individuals with dyslexia. Furthermore, the pars triangularis was significantly associated with leftward asymmetry of the superior temporal gyrus for skilled but not dyslexic participants. For individuals with dyslexia, the cortical asymmetry of the IFG, and the corresponding connections with other reading-related brain regions, is inherently different from skilled readers. We discuss our findings in the context of the print-to-speech framework to further our understanding of the neural underpinnings associated with dyslexia.
The present invention relates to a preparation technology and a production method for an integrated new formulation of a white tiger decoction plus cinnamon twig, wherein the raw material composition of active ingredients thereof is: 180 parts by weight of anemarrhena, 60 parts by weight of honey-fried licorice root, 500 parts by weight of gypsum, 60 parts by weight of polished rice, and 90 parts by weight of cinnamon twig. The production process of the integrated new formulation of white tiger decoction plus cinnamon twig comprises the following steps of: supersonic air-jet crushing, alcohol-water extraction, ultrasonic crushing extraction, water decocting concentration, supersonic spray drying, nanometer grinding, high pressure homogenization, nano particle preparation and the like. According to the invention, the advantages such as multi-synergism, multi-target, embodied by a nano-carrier coupling technique, are focused to be taken of. After the integrated new formulation of white tiger plus cinnamon twig decoction is subjected to scale production, the production cost can be greatly reduced, the quality of products is greatly improved and the targeting property, and the sustained and controlled release performance of the medicament are enhanced. The internal and external administration of the integrated new formulation of white tiger plus cinnamon twig decoction can be realized simultaneously, and the medicament can be separately taken in four time slices according to the midnight-noon ebb-flow and qi and the blood flowing rule of a human body. The integrated new formulation of white tiger plus cinnamon twig decoction can be further prepared into films and transdermal agents, which are respectively stuck to different parts of a human body according to the midnight-noon ebb-flow and qi and blood flowing rule of the human body, and can be directly absorbed through skin.
PURPOSE: Participation is an integral focus of services to people with aphasia and is considered best practice within the scope of practice for speech-language pathology. The Life Participation Approach to Aphasia encourages meaningful participation in life for people living with aphasia. In theory, providing participation-based services to people with aphasia seems logical; however, embedding these constructs of participation into practice can be challenging for speech-language pathologists (SLPs). Project-based intervention (PBI) provides an authentic opportunity to target participation and support identity reformulation in aphasia intervention. Historically, projects have been provided primarily in group-based settings, which may be difficult for the majority of SLPs who primarily offer individual sessions due to reimbursement. This tutorial provides a framework for using PBI in individual sessions for clients with aphasia using five evidence-based components: (a) shared decision making, (b) patient-reported outcomes, (c) goal setting, (d) the project, and (e) ongoing evaluation. Evidence-based tools and a case example are provided to support each component.
CONCLUSIONS: Projects and PBI provide tangible means of placing participation at the center of intervention while also providing opportunities to target language impairments, identity reconstruction, and various environments in a meaningful and personalized way. Projects can be scaled to the client's needs and abilities as well as to the constraints and options of the service delivery setting.
The invention belongs to the technical field of medicaments and provides an antitumor antibiotic and a preparation method thereof. The antitumor antibiotic has a structural formula on the right. The antitumor antibiotic can be obtained from fermentation liquor for culturing streptomycete Y05A-1065(CGMCC No.2363). The antitumor antibiotic is obtained mainly through the steps of culturing strains of the streptomycete Y05A-1065 on a slant surface, preparing the seed liquor of the streptomycete Y05A-1065, preparing the fermentation liquor of the streptomyces Y05A-1065, obtaining total extracts by concentrating thalli, passing culture fluid from which the thalli are removed through an ultrafiltration membrane, performing chromatographic resolution in a silica gel column after extraction with ethyl acetate, and obtaining the antitumor antibiotic after polyamide column chromatography. The method is simple and feasible and good in reproduction quality. The antitumor antibiotic has obvious antitumor activity. The antitumor antibiotic and pharmaceutically acceptable salts thereof are combined with pharmaceutically acceptable carriers thereof to prepare antitumor drugs.
A water soluble biodegradable ABA- or BAB-type triblock polymer is disclosed that is made up of a major amount of a hydrophobic polymer made of a poly(lactide-co-glycolide) copolymer or poly(lactide) polymer as the A-blocks and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall weight average molecular weight of between about 2000 and 4990, and that possesses reverse thermal gelation properties. Effective concentrations of the triblock polymer and a drug may be uniformly contained in an aqueous phase to form a drug delivery composition. At temperatures below the gelation temperature of the triblock polymer the composition is a liquid and at temperatures at or above the gelation temperature the composition is a gel or semi-solid. The composition may be administered to a warm-blooded animal as a liquid by parenteral, ocular, topical, inhalation, transdermal, vaginal, transurethral, rectal, nasal, oral, pulmonary or aural delivery means and is a gel at body temperature. The composition may also be administered as a gel. The drug is released at a controlled rate from the gel which biodegrades into non-toxic products. The release rate of the drug may be adjusted by changing various parameters such as hydrophobic/hydrophilic componenet content, polymer concentration, molecular weight and polydispersity of the triblock polymer. Because the triblock polymer is amphiphilic, it functions to increase the solubility and/or stability of drugs in the composition.
The present invention relates to 2-(substituted aryl group or alkyl group or alkoxyl carbonyl methyl sulphur)-5-alkyl-6-(1-naphthylmethyl) uracil compositions of an S-DABO reverse transcriptase inhibitor, a synthetic method and anti-HIV virus applications thereof. The composition has the following general formula. In the general formula, R1 represents H alkyl and C1 to C5 alkyl; R2 represents C1 to C6 alkyl, C1 to C6 alkoxyl, an aromatic ring-R3, an aromatic heterocyclic ring-R3 and C3 to C6 cycloalkyl-R3; substituted groups R3 on the aromatic ring, the aromatic heterocyclic ring and the C3 to C6 cycloalkyl represent H, 1 to 3 same or different C1 to C3 alkyl, halogen, ether groups of C1 to C3 and OH. 5-alkyl-6-(1-naphthylmethyl) thiouracil is taken as a reactant to be catalyzed by K2 CO3 together with alpha-halogenated ketone or alpha-halogenated acetic acid to obtain the product of the present invention. An experiment indicates that the series compositions have obvious anti-HIV virus activity. The compositions not only can inhibit the duplication of MT-4 cells infected by HIV-1 viruses and has lower cytotoxicity but also can inhibit HIV-2 SOD virus strains. Moreover, the compositions have the certain inhibitory activity on HIV-1 (III[B])variant virus SO561945.
The invention discloses a compound tablet containing telmisartan and hydrochlorothiazide. The tablet is prepared by uniformly mixing telmisartan particles and hydrochlorothiazide particles, and tabletting the mixture. According to the weight of the hydrochlorothiazide particles, the hydrochlorothiazide particles contain 6 to 50 percent of disintegrant. The compound tablet is a single-layer tablet. The telmisartan/hydrochlorothiazide tablet is quickly dissolved and is stable in quality. The invention also provides a preparation method for the compound tablet, which is simple in process, low in cost and suitable for industrial mass production.
The invention discloses a burn and scald ointment composition for preparing a burn and scald ointment. The composition is characterized by containing liquorice, processed garden burnet, ginger, borneol, medicinal wax and independently kept sesame oil. The invention also discloses a preparation method of the burn and scald ointment. The method is characterized by comprising steps of: decocting the licorice root, processed garden burnet, ginger and sesame oil until the licorice turns to black; adding the medicinal wax and decocting to a melt state; then adding borneol and decocting to a boiling state; and filtering the obtained mixed filter, and filtering out a medical decoction and cooling medical decoction. In addition, the invention also discloses a burn and scald ointment prepared by the above method. The burn and scald ointment provided by the invention has short pain killing onset time, short swelling relieving time, long maintenance time and good anti-exudation effect, and leaves no scar after healing. In addition, the burn and scald ointment provided by the invention can also be used as a medicine for treating external trauma.
Background/Objectives: Dietary factors may significantly influence pain management in cancer survivors. However, a substantial gap exists regarding the relationship between nutrition and chronic pain in this population. This study examined differences in diet quality and dietary intake between breast cancer survivors (BCS) experiencing chronic pain and healthy controls (HC). It also aimed to understand the associations between dietary elements and pain-related outcomes within the BCS group. Methods: A case-control study was conducted with 12 BCS experiencing chronic pain and 12 HC (ages 18-65). Data collection included body composition, experimental pain assessments, pain-related questionnaires, and a 3-day food diary to calculate diet quality using the Healthy Eating Index-2015 (HEI-2015) and Dietary Inflammatory Index (DII). Statistical analyses evaluated group differences and associations between dietary factors and pain within the BCS group. Results: There were no significant differences in HEI-2015 scores between BCS and HC, but BCS had a significantly lower DII score (p = 0.041), indicating a more anti-inflammatory diet. BCS also showed higher intake of omega-3, vitamins B6, B12, A, D, and magnesium (p < 0.05). While total diet quality scores did not correlate with pain outcomes, several HEI-2015 and DII components, such as dairy, sodium, protein, vitamin C, and vitamin D, showed moderate positive or negative correlations with pain measures. Conclusions: Despite no overall differences in diet quality, BCS with chronic pain consumed more anti-inflammatory nutrients than HC. Complex correlations between specific dietary components and pain outcomes emphasise the need for further research to explore these links for chronic pain management in BCS.
The invention relates to pharmacology and may be used for producing medicinal agents for treating and preventing viral diseases caused by the herpes, influenza and hepatitis B and C viruses, and also virus-induced immunodeficiencies. A biologically active substance having a polypharmacological effect is made from the green parts and spikelets of cereals of the family Gramineae, genus  Calamagrostis Adans  and/or genus  Deschampsia Beauv , and contains flavonoids, specifically aglycones of the flavonoids tricin, apigenin, luteolin, quercetin and rhamnazin, and/or flavonoid glycosides of tricin, apigenin, luteolin, quercetin, and rhamnazin, and excipients, and has the following composition by mass percent: tricin flavonoid aglycone and/or tricin flavonoid glycosides: 0.016-2.062%; apigenin flavonoid aglycone and/or apigenin flavonoid glycosides: 0.010-1.393%; luteolin flavonoid aglycone and/or luteolin flavonoid glycosides: 0.01-4.979%; quercetin flavonoid aglycone and/or quercetin flavonoid glycosides: 0.001-0.771%; rhamnazin flavonoid aglycone and/or rhamnazin flavonoid glycosides: 0.104-0.203%; excipients: 99.868-90.592%. In this way, the biologically active substance is perfected by determining the specific compositions of the active ingredients thereof, and the physical, chemical and biological characteristics thereof, resulting in the invention of an optimal composition (FIG.  1 ) for achieving an antiviral effect with regard to specific viruses, and dosages when creating medicinal forms. In addition, it has been determined that the biologically active substance is an inducer of a type-γ endogenous interferon, displays an apoptosis-modulating effect, has antioxidant properties and enhances cell resistance to free radical stress. The antiviral effect with regard to specific viruses has been established to be an antiviral effect with regard to the type 2 herpes simplex virus, the influenza virus, and the bovine viral diarrhea virus (hepatitis C virus).
BACKGROUND: Methylphenidate can be used for the treatment of cancer-related fatigue (CRF), although randomized controlled trials have shown conflicting results. The aim of this study was to use 'real-world' data to evaluate the effect and side effects of using methylphenidate in palliative cancer care with a focus on the late palliative phase and dose-response.
METHOD: A retrospective review of medical records from a palliative care unit in Sweden was performed to evaluate the effect and adverse events (AEs) of using methylphenidate to treat CRF. Univariable and multivariable regression was performed and odds ratio (OR) calculated. Adjustments were made for sex, age, cancer type, dose and starting treatment <4 weeks before death.
RESULTS: Of the 2,419 screened patients, 112 had been treated with methylphenidate for CRF. The treatment was assessed as being effective in 51 patients (46%). Twenty-six patients (23%) experienced AEs that were generally mild, including anxiety, palpitations, and insomnia. Patients starting the treatment <4 weeks before death (n = 54) were less likely to have an effect from treatment compared to those starting earlier; adjusted OR 0.24 (95% CI 0.10-0.55). Doses of 20 mg and above were well-tolerated and had a higher frequency of effect in the crude data but not after adjustment for confounding factors.
CONCLUSION: Methylphenidate is generally effective and well-tolerated for the treatment of CRF in palliative care. However, patients with a short life expectancy (<4 weeks) seem to benefit less from the treatment regardless of age, cancer type and dose.
CRT: Frontal/Executive Program. The program has a duration of 40 sessions, with two session for week. Is is carried out individually and utilizes paper and pencil tasks. The main technique utilized is the scaffolding in a context of learning without errors.
PURPOSE: To evaluate the efficacy and safety of a novel humanized anti-HER2 antibody, RC48-ADC (Disitamab vedotin, DV), the combination of RC48-ADC with PD-1 inhibitors was used to treat muscle-invasive bladder cancer (MIBC). This combination therapy has potential applications in both bladder preservation and neoadjuvant therapy for MIBC.
METHODS: Patients with MIBC underwent transurethral resection of bladder tumors followed by RC48-ADC alone or in combination with PD-1 inhibitors. Radiological and endoscopic evaluations were conducted 3 months later. The primary endpoint was objective response rate (ORR), with secondary endpoints including complete response rate (CR), partial response rate (PR), and bladder preservation rate. Treatment safety was assessed according to RECIST v1.1 criteria.
RESULTS: Eleven patients were enrolled, with a median follow-up of 19.0 months. Nine patients achieved objective response, including 6 CR and 3 PR cases. The pathological ORR was 81.8%. Eight patients continued combined treatment after 3 months, maintaining a 72.7% bladder preservation rate at 16 months. One elderly patient progressed from ypT2N0M0 to ypT3N0M0 and underwent radical cystectomy but had no recurrence or metastasis 12 months postoperation. All patients reported varying degrees of treatment-related adverse reactions, which were largely manageable.
CONCLUSION: The combination of RC48-ADC and PD-1 inhibitors proves to be a viable and safe option for bladder-sparing therapy, particularly for T2-stage MIBC patients who are ineligible for surgery and chemotherapy. This approach offers a promising new direction for bladder preservation or neoadjuvant therapy in MIBC patients.
The invention discloses a Chinese herbal medicine for treating acute lumbar sprain and lumbar muscle strain. The Chinese herbal medicine comprises the following traditional Chinese medicine materials by weight: 50g-200g of old crab-eye tree roots, 100g-300g of radix fici hirtae tree roots, 100g-300g of white celtis sinensis tree roots, 20g-50g of radix morindae officinalis, 20g-50g of eucommia barks and 50g-100g of radix ilics pubescentis tree roots. The preparation method of the medicine comprises the following steps of: adding the traditional Chinese medicine materials to a clay pot and then adding water, wherein the ratio of the traditional Chinese medicine materials to the water in proportion by weight is 1:1.2 to 1:1.5; and then, boiling the mixture with strong fire, and re-boiling the mixture with slow fire for 20 minutes, and removing the slag to obtain the liquid medicine. In order to achieve a better therapeutic effect, a cock and white spirit are added to the liquid medicine obtained by removing the slag, and are heated up for 30 minutes with slow fire for taking. The prepared Chinese herbal medicine has a remarkable therapeutic effect of treating the waist diseases such as the acute lumbar sprain, the lumbar muscle strain and the like, so that the waist diseases can be quickly recovered and not easy to recur. Moreover, the Chinese herbal medicine is delicate in conception, simple in preparation method, extensive in application range, and applicable to extensive popularization and use.
Kidney stone disease is common, affecting nearly 10% of the population with increasing prevalence and increasing cost associated to treat this disease. While struvite stones (composed of magnesium, ammonium and phosphate crystals) have been associated with the presence of infection, the association between bacteria and non-infection stones is not well characterized. Previous studies have found bacteria present in stones of patients without active infection and with negative pre-operative urine tests.

There are various compositions of kidney stones, including calcium oxalate, calcium phosphate, struvite and uric acid, with calcium oxalate being the most common. It is well known that struvite stones are associated with active infection, however the role of bacteria in the formation of other types of kidney stones, including calcium oxalate, is not well understood. The investigators hypothesize that bacteria present in the urinary tract of patients without active infection have the ability to facilitate calcium oxalate crystal formation by providing a surface for stones to grow. An understanding of the role of bacteria in the formation of non-infection stones could help prevent stone formation by altering the bacteria present within patients to decrease or eliminate their risk of kidney stone disease.
BACKGROUND: Inguinal hernia develops as one of the common complications after robotic or laparoscopic radical prostatectomy (RP). Transabdominal preperitoneal patch plasty (TAPP) for an inguinal hernia after RP is difficult to perform due to postoperative severe adhesions in the preperitoneal cavity. We have introduced a high peritoneal incision approach (HPIA) in TAPP for inguinal hernia patients in whom peritoneal dissection is difficult due to severe adhesions after RP. We evaluate the safety and efficacy of TAPP with a HPIA for patients with an inguinal hernia after robot-assisted RP (RARP).
METHODS: Patients characteristics and surgical outcome were evaluated by a retrospective analysis.
RESULTS: From January 2014 to December 2017, 21 consecutive patients underwent TAPP for an inguinal hernia after RARP. Twenty-four lesions were the type 3b and three were type 3a according to the Nyhus classification. A circular incision TAPP was performed for 10 hernia lesions in eight patients and TAPP with HPIA was utilized for 17 lesions in 13 patients. The mean operation time for the unilateral hernia in the HPIA (137.8 ± 20.7 min) was significantly shorter than that (182.2 ± 42.0 min) in the circular incision TAPP (p = .038). The HPIA was complete in all patients, while the circular incision TAPP was converted to intraperitoneal onlay mesh (IPOM)intraperitoneal onlay mesh in five patients (55.6%, p = .008) due to dense adhesions with difficult dissection. No recurrent was observed after follow-up period of 48 months in both groups.
CONCLUSIONS: The TAPP with HPIA is feasible and a safe and reliable treatment of choice in patients with an inguinal hernia after RARP.