anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Sex differences in outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) remain controversial. Therefore, the aim of this study was to investigate the sex differences in the prognosis of patients with aSAH.
METHODS: This study retrospectively analyzed the clinical data of aSAH patients admitted to the Department of Neurosurgery of General Hospital of Northern Theater Command, from April 2020 to January 2022. The modified Rankin Scale (mRS) was used to evaluate outcomes at 3-month post-discharge. Baseline characteristics, in-hospital complications and outcomes were compared after 1:1 propensity score matching (PSM).
RESULTS: A total of 665 patients were included and the majority (63.8%) were female. Female patients were significantly older than male patients (59.3 ± 10.9 years vs. 55.1 ± 10.9 years, P < 0.001). After PSM, 141 male and 141 female patients were compared. Comparing postoperative complications and mRS scores, the incidence of delayed cerebral ischemia (DCI) and hydrocephalus and mRS ≥ 2 at 3-month were significantly higher in female patients than in male patients. After adjustment, the analysis of risk factors for unfavorable prognosis at 3-month showed that age, sex, smoking, high Hunt Hess grade, high mFisher score, DCI, and hydrocephalus were independent risk factors.
CONCLUSION: Female patients with aSAH have a worse prognosis than male patients, and this difference may be because females are more vulnerable to DCI and hydrocephalus.
This arm will be the positive control group consuming Ferrous Sulphate drops ( with injera that consist of lab-threshed teff. The Fe drops have to be consumed with the meal and will provide an additional 6 mg of Ferrous sulfate to the diet of the children.
A CCTV is an electro-optical device mainly used for reading, but which can also be used for writing or viewing pictures. It is comprised of a video camera which faces downwards towards the reading material and which inputs the image to a digital monitor. Magnification is variable over a large range. By means of a zoom lens and the brightness, contrast, and image polarity (black letters on white or white on black) can be controlled to provide the best combination of viewing conditions for an individual user. The significant advantages of CCTV over optical magnifiers are that it provides high levels of magnification with a greater field of view (compared to the equivalent optical device), allows reading at a more normal viewing distance of about 40 - 50 cms and allows binocular viewing.
A structured, researcher-designed mindfulness-based psycho-education program (6 months), comprised of 12 bi-weekly, 2-hour group sessions (10-12 patients per group). The program was based on the psycho-education programs by Chien et al. (2010) and Lehman et al. (2004), as well as the 8-session Mindfulness-Based Stress Reduction Program by Kabat-Zinn (1990).
This study aims to understand the impact on parents of having a child with an undiagnosed medical condition and the factors that contribute to their adaptation. Rare and undiagnosed conditions are often chronic and disabling, with symptoms affecting different organ systems at various levels of severity. Perhaps the most challenging feature of an undiagnosed medical condition that has lasted two or more years, however, is its characteristic uncertainty. In the absence of a diagnosis, health care professionals can provide only limited treatment and prognostic information. It is not well understood how individuals cope with and adapt to chronic uncertainty, and the factors that influence this process. To design future interventions, descriptive studies are needed to reveal predictors that can be manipulated to improve outcomes. In this study, Lazarus and Folkman's Transactional Model of Stress and Coping provides a framework to examine coping and adaptation in the parents of children who have had a chronic, undiagnosed medical condition for two or more years. A cross-sectional research design using a mixed methods survey will be used to examine the relationships among appraisals (perceptions of uncertainty and perceived personal control), time elapsed since parents first realized their child was sick, coping and adaptation. Parents will be recruited from web-based support networks for parents of undiagnosed children via website postings, email listservs and printed newsletter postings. Participants will have the option to complete an online or paper version of the questionnaire. The main outcome variable is adaptation to living with one's child's undiagnosed medical condition.
FIELD: preparation of food products for prevention of diseases. SUBSTANCE: food product contains deuterium up to 111-135 ppm. The method provides for production of water containing deuterium in the amount of 111-135 ppm by the method of standard electrolysis and/or distillation, and the produced water used as nutrient solution in growing of algae or for irrigation of plants used in food industry. As a result, algae and plants with low content of deuterium, or water with deuterium content of 111-135 ppm is used in production of nonalcoholic beverages and beer. EFFECT: production of food products preventing development of tumors and eliminating tumors of nondetectable sizes. 2 cl
PROBLEM TO BE SOLVED: To obtain a liquid medicine composition combined with loperamide hydrochloride, containing the loperamide hydrochloride and a nonion surfactant, capable of reducing bitterness of the loperamide hydrochloride and enabling an oral administration without suffering. SOLUTION: This liquid medicine composition combined with loperamide hydrochloride contains the loperamide hydrochloride and a nonion surfactant (e.g. a castor oil cured by polyoxyethylene) as active ingredients. A glycyrrhiza extract is preferably combined because the bitterness of the loperamide hydrochloride is more reduced thereby. The content of each component is 0.0005-0.01wt.% loperamide hydrochloride, 0.01-5wt./vol.% nonion surfactant and 0.001-10wt.% glycyrrhiza extract. The components are formed into a drinkable preparation, syrup, etc., by using a conventional method and optionally combining with other usual components. Further, an adsorption of the loperamide hydrochloride on a vessel wall, which is caused by the dissolution of the loperamide hydrochloride, is prevented.
Supraclavicular block is performed under ultrasound guidance. Linear probe is placed on the ipsilateral supraclavicular fossa visualizing the brachial plexus located lateral to the subclavian artery. Using in-plane technique, nerve stimulation needle is advanced into the brachial plexus sheath, into which 25 ml of 1.5% mepivacaine is injected.
A method and a system of collaborative cross-provider reverse bidding on a component of a consumer medical service. A method includes determining that a user has submitted a request data related to a medical service, automatically selecting components required to fulfill a medical service, and listing the components in an online medical marketplace. The components are determined to have received compatible bids from one or more providers and may be verified to comply with geographic and/or time constraints. A symptom is associated with a diagnosis, and the set of components effecting an alternative approach to resolving the diagnosis are automatically selected. A response data is communicated to the user, and the response data may include the components with associated bids from each of the providers. In yet another embodiment, a system includes a server, a processor, a horizontal array engine, a vertical array engine, the online medical marketplace, and a network.
A wearable drug delivery device for monitoring unintended over-delivery and/or under-delivery of a stored liquid drug are provided. An absolute pressure sensor can be positioned within the fluid path of the drug delivery device. The absolute pressor sensor can detect both ambient pressure (e.g., absolute or atmospheric pressure) and relative pressure (gage or pumping pressure). Based on the detected pressures, the effects of external ambient pressure on air with the fluid path can be determined during both intended drug delivery events and unintended drug delivery events. In turn, under-delivery and/or over-delivery of the liquid drug can be determined. Based on the severity of the determined under-delivery or over-delivery of the liquid drug, alarms indicating different urgencies can be provided to the user.
Persistent negative mood, melancholy and depression are becoming more and more prevalent worldwide. Depression is linked to severe functional impairment, which can last for years, and to a significant reduction in quality of life. Current theoretical models of depression suggest that negative mood and depressive symptoms are associated with decreases in cognitive control abilities - the same brain mechanisms in the prefrontal cortex that underlie goal-directed behaviors. Specifically, difficulty in delaying a response to irrelevant negative information, or difficulty in removing irrelevant negative information from working memory, have all been found to be associated with and predictive of depressive symptoms. Indeed, research findings from subclinical and clinical populations show that depressive symptoms are associated with decreased cognitive control ability and decreased activity in the prefrontal cortex regions.

In the present study, the investigators will examine whether training of cognitive control improves mood. Specifically, the investigators will test whether several weeks of training using a tablet video game targeting cognitive control improves depressive symptoms, mood, and cognitive control abilities measures among adults. Participants will be randomized to receive either a high or low dose of the intervention or a control intervention, and will be asked to train with their intervention remotely from home for 3 weeks. Outcomes will be assessed at baseline, at the completion of training and at two follow up points: 3 weeks and 3 months.
A problem of the present invention is to provide a skin collagen production-promoting agent without safety problems. Another problem of the present invention is to provide a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product containing such a substance.  TGF-.beta. and/or a TGF-.beta. degradation product, which is acquired by degrading TGF-.beta. with a protease such as pepsin, pancreatin, etc., are used as a skin collagen production-promoting agent or the active ingredient of a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product. The aforementioned TGF-.beta. and/or TGF-.beta. degradation product have an effect of increasing the collagen content of the skin.
Recovery of locomotion is a primary goal of rehabilitation post-stroke and a major determinant of future morbidity and mortality. While substantial recovery is observed early post-stroke, recent evidence suggests the magnitude and time course of recovery is deterministic and based primarily on initial motor deficits. The "proportional recovery" rule suggests \~70% of neurological recovery (measured by the lower limb Fugl-Meyer Assessment - LL-FMA) is typically achieved and is not influenced by the dosage of therapy. These findings suggest the physical interventions applied to patients are of minimal importance to long-term recovery. That hypothesis conflicts directly with our recent efforts suggesting that maximizing the amount and intensity of task-specific (stepping) practice (high-intensity training; HIT) directly influences gains in locomotor function. Providing HIT at heart rates (HRs) greater than traditional aerobic paradigms (mean 110% baseline HRmax) is associated with gains in locomotor speed, which challenges the notion of "proportional recovery".

These conflicting hypotheses likely arise from differences in terminology and methodology used to characterize recovery post-stroke. First, the traditional measure of neurological recovery (LL-FMA) does not adequately characterize other impairments (strength, postural stability) that are more closely associated to locomotor function and are responsive to physical interventions. Second, despite gains in selected impairments, patients often utilize alternative (compensatory) movement patterns to accomplish locomotor tasks. More directly, locomotor recovery (i.e., speed/distance) is often accomplished using strategies employed prior to stroke and compensatory strategies, particularly in those with substantial impairments.

Our central hypothesis is that if changes in neurological recovery are deterministic, other measures of locomotor recovery or compensations may also be predictable. Our published data detail how HIT or conventional interventions can alter impairments and locomotor recovery, as well as changes in locomotor compensations. More directly, our data provide evidence that specific subgroups of patients demonstrate substantial compensations with improved recovery, whereas others reveal limited changes despite similar interventions. Data that detail the progression of neurological recovery, locomotor recovery, and locomotor compensations throughout the subacute to chronic phase post-stroke and their responsiveness to HIT is uncertain. Similar to upper limb recovery algorithms, predictions of mobility outcomes could provide valuable information to clinicians who make decisions regarding patient's prognosis, including whether patients will be able to walk with or without assistance or at certain speeds, and what compensatory strategies they may require to ambulate independently (braces, devices or altered movement patterns). The overarching goal of this project is to examine the time course of neurological and locomotor recovery, and associated compensatory strategies, over the subacute to chronic stages post-stroke and their responsiveness to HIT.
PROBLEM TO BE SOLVED: To provide a method and a system for advice for diet using the Internet. SOLUTION: A user registered in the system sends meal data of each meal to a system controller via the Internet for an analysis, and receives an advice for the diet without restrictions on time and place. After the registration of initial data, there are three stages to proceed with, that is, nutrition balance, meal balance and calorie balance. A target value is determined for every user, and the user receives the advice based on the comparison with the target value, from the system controller through the Internet. The contents of counseling are set to have the atmosphere and contents of counseling of a nutrition expert, and can be used as the index of health care together with other data. With the natural diet, obesity and hidden obesity are prevented, and rebound is prevented while protecting privacy. Further, neutral fat is reduced while maintaining active tissue.
The invention discloses a packaging composition of a proton pump inhibitor drug for injection. The packaging composition of the proton pump inhibitor drug for injection is prepared by packing the following active components and non-active components in parts by weight in a borosilicate glass bottle, covering the bottle by a rubber plug, combining and sealing. The active components and non-active components in parts by weight are as follows: 0.5-2 parts of a proton pump inhibitor, 0-0.1 part of oxalic acid diethylamine disodium, 0-0.1 part of alkali and 0-3 parts of a skeleton agent. A preparation method of the packaging composition of the proton pump inhibitor drug for injection comprises the following steps: dispensing liquid, pre-freezing, primarily drying, secondarily drying and post-treating. The neutral borosilicate glass bottle is selected, so that the compatibility of the proton pump inhibitor drug for injection can be obviously improved; the drug quality is improved; the risk of transferring glass corrosion caused by alkaline drug to the drug is reduced; furthermore, the clinical safety of the drug is improved. The preparation method of the proton pump inhibitor drug for injection is simple in process, low in energy consumption, convenient to operate, safe to produce and suitable for industrial large-scale production and application.
Patients are observed if their transient myeloproliferative disorder (TMD) does not require intervention. Patients who require therapy for TMD undergo leukapheresis or exchange transfusion for up to 3 consecutive days. If the TMD does not resolve or there is significant organ involvement, patients receive low-dose cytarabine IV continuously on days 0-4. Treatment repeats at least every 2 weeks for up to 4 courses. Patients who experience a recurrence of TMD at least 8 weeks after resolution or have refractory disease may proceed to group II for further treatment. patients will continue to be followed for remission induction, EFS, DFS and OS regardless of the type of leukemia that develops.
BACKGROUND: Perioperative chemotherapy is the standard treatment for locally advanced gastric cancer. However, the potential benefit of extending therapy before surgery remains largely unknown. In this study, we aimed to evaluate the efficacy and safety of total neoadjuvant chemotherapy, with or without immune checkpoint blockade.
METHODS: A cohort of 174 patients with clinical stage III gastric cancer who underwent D2 gastrectomy from October 2021 to March 2024 in the real-world setting were included in this study. Among these patients, 101 were treated with total neoadjuvant therapy (TNT) and 73 were treated with perioperative neoadjuvant therapy (PNT). We compared the pathologic complete response (pCR) rate, ypN0 rate, recurrence-free survival (RFS), overall survival (OS), and postoperative complications between the 2 groups. Multivariate logistic regression analysis was conducted to identify factors associated with pCR or ypN0.
RESULTS: Compared with the PNT group, the patients in the TNT group were more frequently treated with intensive chemotherapy with triplets + immunotherapy. Apart from this, there were no significant differences in baseline characteristics. There were no statistically significant differences in pCR (16.8% vs 12.3%), ypN0 (49.5% vs 38.4%), RFS, OS, and postoperative complications (27.7% vs 26.0%) between the TNT and PNT groups. Older age, diffuse type, and stable disease/progressive disease based on clinical efficacy evaluation were independently associated with non-pCR. Stable disease/progressive disease, linitis plastica, and poor differentiation were independently associated with ypN+. Neither the number of neoadjuvant therapy cycles nor the specific regimens were associated with pCR or ypN0. In the subgroup analysis of patients receiving total gastrectomy, there were still no statistically significant differences in pCR (16.7% vs 2.6%), ypN0 (43.8% vs 39.5%), and postoperative complications (45.8% vs 36.8%) between the 2 groups.
CONCLUSION: Although TNT did not increase the postoperative complication rate, it also did not provide any additional short-term benefits compared with PNT for clinical stage III gastric cancer.
Nicotine replacement therapy combined with contingency management. Non-responders switch to varenicline or bupropion combined with contingency management for second 12 weeks.
Intravenous infusion of iNK cells is given to the subject, 5\*108 to 1\*109 cells/dose, two doses per week, a total of 8 doses. And then 1\*109 cells/dose, one doses every 4 weeks , a total of 5 doses.
A process for obtaining immune lactoglobulins wherein a cow is immunised by injecting an antigen by scarification, subcutaneous or intra-muscular injection, then continuing injections of the antigen into the retro-mammary ganglions, collecting the milk and isolating the lactoglobulins. A cow was immunised at the beginning of its lactation period by injection (scarification) with a virus vaccine (80 ml., concn. 1 X 106.7) followed 2 weeks later by intra-muscular injection of 10 ml. of vaccine, then on successive weeks by 20 ml. 50 ml. and 100 ml. vaccine. Two months after the final vaccination, the cow was injected with 20 ml. vaccine into the centres of its two retro-mammary ganglions and the injections continued weekly for 5 further weeks. At the end of the 19 week treatment the lacto serum antibody concn. was now constant.
BACKGROUND: This study examines the professional quality of life (ProQOL), including compassion satisfaction (CS) and compassion fatigue (CF), burnout (BO) and secondary traumatic stress (STS) among registered nurses in the context of pediatric care in Riyadh city in Saudi Arabia.
METHODS: This study utilised a random multistage sampling method and a survey to collect data from 250 participants on personal characteristics, work-related aspects, lifestyle, and professional quality of life.
RESULTS: The study participants were all female. Only 2.0% were under 25, with 27.2% aged between 25 and 30 years, 24.0% aged between 31 and 35, and 26.4% over 40 years old. The majority, 74%, were non-Saudis. The participants reported low compassion satisfaction (CS) and compassion fatigue (CF) levels. The CS, burnout (BO), and secondary traumatic stress (STS) scores were 3.23 ± 0.764, 2.75 ± 0.68, and 2.69 ± 0.54, respectively. The study found a significant difference in ProQOL level based on factors such as age, nationality, previous experience, department, shift length, overtime work, state of overtime (mandatory versus optional), and salary.
CONCLUSIONS: Working with vulnerable groups poses unique challenges for pediatric nurses. The nationality, salary, and state of overtime were found to be significantly different when compared to CS scores. Additionally, age, department, previous experience, shift length, and overtime work were very different compared to CF scores. However, lifestyle factors did not affect CS and CF scores significantly.
IMPLICATIONS: To improve their well-being and interest in activities, pediatric nurses should practice self-compassion and utilise available educational resources such as workshops. They should also strive to achieve a work-life balance and adopt healthy habits to reduce CF.
Intervention: Short Regimen with Rifapentine 10mg/kg consists of two periods of 17- 26 weeks. The first is an intensive phase of 8 weeks, and included rifapentine, isoniazid, pyrazinamide, and moxifloxacin. This is followed by a continuation phase of 9 weeks with the following agents: rifapentine, isoniazid and moxifloxacin (extended up a maximum of 18 weeks if no smear conversion at the end of 8 weeks or the tuberculosis cavity is not closed at the end of 17 weeks).
PURPOSE:To obtain an external drug having suppressed tackiness caused by polyol by using a glycerol-alpha-mono(lower)alkyl ether in combination with a polyol containing >=3 hydroxyl groups such as glycerol or sorbitol. CONSTITUTION:The objective external drug can be produced by compounding a glycerol-alpha-mono(lower)alkyl other (e.g. glycerol-alpha-monomethylether) in combination with a polyol containing >=3 hydroxyl groups in the molecule (e.g. polyhydric alcohol such as glycerol, polyglycerol, sorbitol, xylitol and maltitol). The drug exhibits humectant effect and excellent tackfree feeling to the skin. The amount of the glycerol-alpha-mono(lower)alkyl ether in the drug is >=0.1% and preferably about >=1/10 pts. per 1 pt. of the polyol.