anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
She will receive standard breastfeeding support after delivery. Breastfeeding will not receive continuous breastfeeding support for the first 6 months after discharge.
BACKGROUND: In April 2020, an association between multisystem inflammatory syndromes (MIS-C) was observed in children with severe acute respiratory syndrome coronavirus infection (SARS-CoV-2). Most patients had heart involvement alone, and most patients had pericardial effusion. This study aimed to express and emphasize cardiac involvement in pediatric patients with respiratory symptoms who were diagnosed with COVID-19.
METHODS: This study was conducted in July 2021 in Kerman province, Southeastern Iran, during a notable surge in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The study included 904 pediatric patients diagnosed with COVID-19. Data collection involved a comprehensive assessment of clinical symptoms and manifestations. Patients with fever lasting more than five days were admitted to the hospital. Echocardiography was utilized for cardiac involvement diagnosis, with 47 patients undergoing this diagnostic procedure.
RESULTS: Of the 904 patients, most of them had high fevers (74%). Fifty-five patients had a fever for more than five days and were hospitalized. Of the 47 patients who underwent echocardiography, 45 (81%) had heart involvement. In 75% of patients, pericardial effusion was the only cardiac involvement. Patients with pericardial effusion were treated with dexamethasone up to 3 mg every 8 h for 72 h.
CONCLUSIONS: MIS-C has a wide range of clinical symptoms. In cases where the fever is prolonged and there are gastrointestinal symptoms, physicians have clinical suspicion to diagnose this syndrome. Most cases of pericardial effusion are alone and improve with treatment with glucocorticosteroids.
A method is described of obtaining keratin products (insoluble keratin microfibres and soluble keratin) from livestock waste such as feathers, hair, hide, hooves or horns. The method is carried out in cold conditions and consists of a succession of stages of mutual shredding and hydrolysis of the waste and oxidisation in order to obtain both products, followed by stages specific to each of them. The subsequent stages to obtain soluble keratin are adjustment to pH neutral, ultrafiltration, washing and drying by means of spraying and lyophilization. The soluble keratin obtained in this way has characteristics that make it suitable for use in the cosmetics and animal and human food industries. The subsequent stages to obtain insoluble keratin microfibres are adjustment to pH acid, decantation, adjustment to pH neutral and washing, further decantation, further washing, additional decantation and a polymerisation phase in order to obtain keratin fibres with greater polymerisation and larger size. The insoluble keratin microfibres obtained in this way have increased properties of resistance and elasticity, for use in the textile industry, in the manufacture of polymers and paper, and in the production of biomaterials.
Embodiments of this invention provide improved medical decision support systems and methods for using such systems to simultaneously consider two or more different types of information along with estimates of accuracies of the information to produce a combined predictor (Figure 1). Such predictors have greater accuracy compared to use of the individual types of information alone. Increased accuracy can increase the likelihood of correct diagnosis and/or evaluation of clinical condition or outcome, and can decrease the frequency of false negative results, including misdiagnosis. Embodiments of medical decision support systems can include EFuNN, Bayesian or other statistical estimators to produce a combined predictor. The systems can be used to extract relationship rules between sets of genes and clinical variables common for patients of a group, thus making a personalized gene-based treatment possible. Such systems are incorporated into computer-based devices and are run using suitable computer programs.
There was no evidence on the relationship of Dietary Approaches to Stop Hypertension (DASH) with metabolic health condition in adolescents with overweight and obesity. The purpose of this research was to investigate the association of priori-defined DASH dietary pattern with metabolic health status among adolescents with overweight and obesity in Iran. A cross-sectional survey performed on a representative sample of adolescents with overweight and obesity (n = 203). Dietary intakes were collected via a validated food frequency questionnaire and DASH score was characterized according to eight components. Data of anthropometric measures, blood pressure, circulating insulin, fasting blood sugar, and lipid profile were collected. Metabolic health status was defined based on criteria of International Diabetes Federation (IDF) and insulin resistance (IR). Based on IDF and IDF/IR criteria, 38.9% and 33.0% of adolescents suffered from metabolically unhealthy overweight/obesity (MUO). After controlling all confounders, subjects in the highest vs. lowest tertile of DASH diet had respectively 92% and 91% lower odds of MUO based on IDF definition (OR = 0.08; 95%CI 0.03-0.22) and IDF/IR criteria (OR = 0.09; 95%CI 0.03-0.29). Subgroup analysis by sex and body mass index determined that this relationship was more powerful in girls and overweight individuals. Also, in fully adjusted model, highest vs. lowest adherence to DASH diet was linked to decreased odds of hyperglycemia (OR = 0.07; 95% CI 0.03-0.21), hypertriglyceridemia (OR = 0.26; 95% CI 0.09-0.73), low HDL cholesterolemia (OR = 0.30; 95% CI 0.12-0.73) and insulin resistance (OR = 0.07; 95% CI 0.02-0.28), as metabolic health components. Greater compliance to DASH dietary pattern was linked to a remarkable lower odd of metabolic unhealthy condition among Iranian adolescents, especially in overweight subjects and girls. More prospective surveys are required to assert these results.
The present invention relates to cosmetic compositions comprising an oil phase, a polyol phase and a phase. The oil phase comprises polysiloxane-11, a mixture of dimethicone, dimethicone crosspolymer, and cetyl peg/ppg-10/1 dimethicone, ethylhexyl palmitate, and a hyaluronic acid derivative. The polyol phase includes ascorbic acid, ascorbyl glucoside, propylene glycol, glycerin, and hydroxyethylpiperazine ethanesulfonic acid. The third phase comprises slippery elm bark extract. The cosmetic composition provides an immediate soft focus effect and a long-term anti-wrinkle effect. The invention also relates to a method for preparing the cosmetic composition.
The invention relates to the technical field of traditional Chinese medicine, and especially relates to a medicine used for preventing and treating hypertension. The medicine is composed of the medicine materials of, by weight: 10-20 parts of sharpleaf gambirplant stem with hooks, 5-15 parts of lotus seed core, 5-15 parts of epimedium, 25-50 parts of wild chrysanthemum, 25-50parts of stephania tetrandra, 10-30 parts of lobed kudzuvine root, 5-15 parts of dogbane, and 5-20 parts of golden thread. The traditional Chinese medicine has a reasonable formula, and is designed with a five-element allelopathy principle. The traditional Chinese medicine follows the law of nature. The traditional Chinese medicine is a valuable traditional Chinese medicine with preventing and treating effects against hypertension and no toxic or side effect. When the medicine is taken for a long time, no damage is caused to human heart, brain, kidney, and liver.
The following adverse reactions have been identified during post approval use of fluoxetine. Because these reactions are reported voluntarily from a population of uncertain size, it is difficult to reliably estimate their frequency or evaluate a causal relationship to drug exposure.

Voluntary reports of adverse reactions temporally associated with fluoxetine that have been received since market introduction and that may have no causal relationship with the drug include the following: aplastic anemia, atrial fibrillation , cataract, cerebrovascular accident , cholestatic jaundice, dyskinesia (including, for example, a case of buccal-lingual-masticatory syndrome with involuntary tongue protrusion reported to develop in a 77-year-old female after 5 weeks of fluoxetine therapy and which completely resolved over the next few months following drug discontinuation), eosinophilic pneumonia , epidermal necrolysis, erythema multiforme, erythema nodosum, exfoliative dermatitis, gynecomastia, heart arrest , hepatic failure/necrosis, hyperprolactinemia, hypoglycemia, immune-related hemolytic anemia, kidney failure, memory impairment, movement disorders developing in patients with risk factors including drugs associated with such reactions and worsening of pre-existing movement disorders, optic neuritis, pancreatitis , pancytopenia, pulmonary embolism, pulmonary hypertension, QT prolongation, Stevens-Johnson syndrome, thrombocytopenia , thrombocytopenic purpura, ventricular tachycardia (including torsades de pointes–type arrhythmias), vaginal bleeding, and violent behaviors . 1111111

These terms represent serious adverse events, but do not meet the definition for adverse drug reactions. They are included here because of their seriousness. 1
The invention relates to chemical and pharmaceutical branches, in particular, to a mixture for determining originality of quality control a medicine “Glycine tablets sublingual 0.1 g.”, a method for preparation thereof and a method for determining originality of quality control of said medicine. The mixture comprises 50% ethyl alcohol and crushed to powder tablets “Glycine tablets sublingual 0.1 g.” in the range 100:0.5. The mixture is prepared by diluting 1.25 g. of crushed in powder tablets in 250 mg of the 50% ethyl alcohol during 20 min. at 40°C in a tester for determining dilution at rotation speed of an impeller mixer being 200 rev/min. The mixture is maintained at room temperature during 10 min. A method for determining the medicine originality comprises preparation of aqueous alcoholic mixture using 50 % ethyl alcohol as described above. After that a 4 ml. sample of the mixture is selected and value of optical transmission is measured with 700±2 nm wave length in a dish, a layer thickness is 1o mm. relative to the 50% ethyl alcohol. An aqueous mixture is prepared during 20 min. at 37°C by diluting 2.5 g. crushed to powder tablet in 250 ml. of purified water. The aqueous mixture is tested similar to that carried out for the aqueous mixture. Further the difference of values between the optical transmission of the aqueous alcoholic mixture and the optical transmission of the aqueous mixture is determined and subsequently the obtained value is compared with a range from 30% to 50%.
INTRODUCTION: Groin hernia is one of the most commonly managed surgical diseases around the world. The typical question asked by patients is "Does my hernia require urgent surgery?". The currently available classifications are insufficient to stratify patients into different groups. We propose a new classification that incorporates diverse clinical elements together with anatomical and other vital information, which allows us to stratify patients into different groups.
METHOD: A task force was formed by the Hong Kong Hernia Society, working with international expert hernia surgeons. The framework of the classification system was formulated. Clinical elements that are important in groin disease stratification were identified. A comprehensive literature review was conducted using PubMed. Those which dictate the severity of the disease were selected and compiled to form the new proposed classification. Application of this classification model to a single hernia surgeon's registry in The Hong Kong Adventist Hospital Hernia Centre was done for initial evaluation.
RESULT: This new classification incorporates important clinical characteristics forming a total of nine grades of differentiation, together with the anatomical details and special information. This comprehensive system allows the stratification of patients into different groups based on disease severity. It also enables more accurate data collection for future audits, comparisons of disease progression over time, and the effect of different management strategies for different-stage patients.
CONCLUSION: This is the first classification system which incorporates essential clinical parameters, which allows the stratification of groin hernia into different stages. Further studies and validation should be performed to evaluate the usefulness and value of this classification in groin hernia management.
The invention discloses a traditional Chinese medicine moxibustion therapy patch for treating arthromyodynia. According to the invention, grinded musk, tiger beetles, realgar and borneol are grounded into powder, and the powder is mixed with honey and applied to cloth, and then the cloth is attached to related meridian points and focuses. According to reasons of arthromyodynia, arthromyodynia is divided into migratory arthralgia, arthritis, pyretic arthralgia and fixed impediment by means of syndrome differentiation in traditional Chinese medicine science. The patch disclosed by the invention eliminates dampness, clears away heat and dredges channels and collaterals. As the patch disclosed by the invention is capable of improving the immunity of the organism and motivating channel qi, the patch can achieve the functions. Furthermore, the patch realizes two-way regulation: cold and heat as well as virtuality and reality, so that the patch can take effect quickly.
This is an 8-week randomized, double-blind, placebo-controlled, parallel, fixed-dose pilot clinical trial of curcumin for the treatment of cognitive impairment in schizophrenia. Cognitive impairment and persistent negative symptoms are the core dimensions of schizophrenia; however current antipsychotic treatment fails to address this issue. Evidence suggests cognitive impairment is not only limited to patients with late-stage schizophrenia. High rates of cognitive impairment in patients with first episode psychosis indicate that cognitive impairment is not solely a consequence of long-term antipsychotic treatment, but rather is an enduring problem over the course of schizophrenia. Likewise, negative symptoms persist throughout its entire course, and are associated with poor overall functioning. Currently, there are no pharmacological agents that specifically aim to treat cognitive functioning and persistent negative symptoms; therefore, there is growing interest in the development of effective treatments for this unmet need.

The primary aim of this pilot trial is to provide an effect size estimate for the efficacy of curcumin in improving cognitive functioning in schizophrenia. Secondary goals are to determine the effect of curcumin over time on negative and positive symptoms, in association with inflammatory markers. Eligible participants will be randomized to curcumin (n=20) or placebo (n=20) in a 1:1 ratio. A commercially available surface-controlled water soluble form of 600mg curcumin (10% formulation) or matching placebo capsules will be administered three times a day for a total of 8 weeks.
Epithelial-to-mesenchymal transition (EMT) triggers cell plasticity in embryonic development, adult injured tissues and cancer. Combining the analysis of EMT in cell lines, embryonic neural crest and mouse models of renal fibrosis and breast cancer, we find that there is not a cancer-specific EMT program. Instead, cancer cells dedifferentiate and bifurcate into two distinct and segregated cellular trajectories after activating either embryonic-like or adult-like EMTs to drive dissemination or inflammation, respectively. We show that SNAIL1 acts as a pioneer factor in both EMT trajectories, and PRRX1 drives the progression of the embryonic-like invasive trajectory. We also find that the two trajectories are plastic and interdependent, as the abrogation of the EMT invasive trajectory by deleting Prrx1 not only prevents metastasis but also enhances inflammation, increasing the recruitment of antitumor macrophages. Our data unveil an additional role for EMT in orchestrating intratumor heterogeneity, driving the distribution of functions associated with either inflammation or metastatic dissemination.
Hypertension is one of the most common world-wide chronic diseases, and it is showing a growing younger trend, which with mild blood pressure elevated would not be diagnose in time until blood pressure raises up or symptoms show up (Mild blood pressure indicates blood pressures ranging from 140 to 159 mmHg systolic and/or 90 to 99 mmHg diastolic). However, cumulative evidences prove that microvascular rarefaction exist in hypertensive patients with even primary hypertension stage 1. Exercise prescription is gathering great importance in preventive health. Aerobic exercise, especially, has the potential to diminish blood pressure values, and aerobic exercise can promote angiogenesis in coronary heart disease. Notch signaling plays an important role in vascular formation and maintenance. However, there is no prospective, randomized, controlled, clinic trial to investigate the effect of exercise on microcirculation rarefaction in hypertension. In summary, investigators propose a hypothesis that aerobic exercise might not only have a blood pressure lowing effect but also improve microcirculation rarefaction in Chinese male adults with primary mild hypertension. For that, subjects will be enrolled for one pre-intervention cardiopulmonary exercise test (CPET) and then randomized in aerobic exercise intervention group and control group (only health education), the intervention will be carried out by Cycle Ergometer, the protocol consists of 3 sessions a day: 3 minutes Warm up, 45 minutes Resistance Exercise at 75% of HRmax; 10 minutes Recovery. Thus 58 minutes a day and 5 days a week (about 2000kcal) and 12 weeks in total. Prior and after all intervention sessions (12 weeks), nail fold capillary microscopy and retinal capillary Optical Coherence Tomography(OCT) angiography will be assessed, as well as 24h blood pressure monitoring, echocardiography, forearm blood Flow Mediated Diastolic function(FMD), Plus Wave Velocity(PWV), Reactive Hyperemia Index(RHI) with Endopat, also the quantification of endothelial progenistor cells(EPCs) separated from peripheral blood.
A function of a naturally existing cyanobacteria, aiming to provide a photosensitizer having a simple preparation process. It utilizes the characteristics that cyanobacteria photosynthetically produces oxygen after being irradiated, thus producing oxygen by itself to overcome the microenvironment of tumor hypoxia, so as to target the tumor and exert an effective photodynamic effect. Experiments in vitro have demonstrated that cyanobacteria are able to effectively inhibit the growth of 4T1 cells after being irradiated with a laser having a wavelength of 660 nm. The present invention has the advantages of simple process steps and low cost. By simply amplifying and culturing cyanobacteria in large quantities, and giving specific light irradiation thereto, oxygen can be self-supplied, thereby overcoming tumor hypoxia and exerting the effect of photodynamic therapy. Furthermore, the present invention has developed an oxygen self-producing photosensitizer having industrial practical value.
INTRODUCTION: Onabotulinumtoxin A (BTX-A) is a well-established treatment for overactive bladder (OAB). The American Urological Association (AUA) 2008 Antibiotic Best Practice Statement (BPS) recommended trimethoprim-sulfamethoxazole or fluoroquinolone for cystoscopy with manipulation. The aim of the study was to evaluate concordance with antibiotic best practices at the time of BTX-A injection and urinary tract infection (UTI) rates based on antibiotic regimen.
METHODS: Men and women undergoing first-time BTX-A injection for idiopathic OAB with 100 units in 2016, within the SUFU Research Network (SURN) multi-institutional retrospective database were included. Patients on suppressive antibiotics were excluded. The primary outcome was concordance of periprocedural antibiotic use with the AUA 2008 BPS antimicrobials of choice for "cystoscopy with manipulation." As a secondary outcome we compared the incidence of UTI among women within 30 days after BTX-A administration. Each outcome was further stratified by procedure setting (office vs. operating room; OR).
RESULTS: Of the cohort of 216 subjects (175 women, 41 men) undergoing BTX-A, 24 different periprocedural antibiotic regimens were utilized, and 98 (45%) underwent BTX-A injections in the OR setting while 118 (55%) underwent BTX-A injection in the office. Antibiotics were given to 86% of patients in the OR versus 77% in office, and 8.3% of subjects received BPS concordant antibiotics in the OR versus 82% in office. UTI rates did not vary significantly among the 141 subjects who received antibiotics and had 30-day follow-up (8% BPS-concordant vs. 16% BPS-discordant, CI -2.4% to 19%, p = 0.13). A sensitivity analysis of UTI rates based on procedure setting (office vs. OR) did not demonstrate any difference in UTI rates (p = 0.14).
CONCLUSIONS: This retrospective multi-institutional study demonstrates that antibiotic regimens and adherence to the 2008 AUA BPS were highly variable among providers with lower rates of BPS concordant antibiotic use in the OR setting. UTI rates at 30 days following BTX-A did not vary significantly based on concordance with the BPS or procedure setting.
Described are coloured 5-aminolevulinic acid (ALA) crystals for photodynamic therapy.  Preferably the coloured 5-aminolevulinic acid crystals have the colour imparted by irradiation of the crystals, such as gamma radiation.  The coloured ALA crystals are preferably pharmaceutically pure and sterile and can be contained in a sealed sterile container.  Also described is a sterile aqueous ALA solution that includes the coloured ALA crystals contained in water.  Also described is a method for preparing coloured ALA crystals, which includes exposing non-irradiated ALA crystals to a radiation source at a dose sufficient impart a colour which is different than any colour present in the non-irradiated crystals.  Preferably the irradiation is sufficient to sterilize the ALA crystals.  The sterile coloured ALA crystals can be used in a kit for internal or external treatment and/or detection of a condition in a mammal, which includes the sterile, coloured ALA crystals and sterile diluent, and in the case of internal treatment and/or detection optionally a catheter for administration of the ALA.