anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An age-stratified random sample of (young) adults with CHD, followed-up at the University Hospital of Leuven and the Ghent University Hospital will be included. Age strata for this study are: 18-24y; 25-34y; 35-44y; 45-54y; 55+. In total 500 patients will be included, 100 in each age stratum.
Participant will undergo the cardiac catheterization or electrophysiology implant procedures per standard of care. Meaning, without the ControlRad system installed in Cath lab room 5.
Physical inactivity is particularly prevalent in women of low socioeconomic position (SEP) (60% are inactive), suggesting that there are structural barriers to being physically active. This study will test the effectiveness of an intervention to increase physical activity among mothers of low SEP, where there is high risk of chronic disease and significant potential to make an impact on these health disparities.

This study comprises a 3-arm parallel cluster randomized controlled trial with low-resourced mothers living in New York City. The study team will randomize fitness class sites (clusters) into Arm A (contact control), receipt of free weekly fitness classes; Arm B, receipt of free childcare combined with free weekly fitness classes; and Arm C, receipt of free childcare combined with free weekly fitness classes and, plus peer support activities. Over two years the study team will recruit eight waves totaling 630 participants into 21 fitness classes. Physical activity is the primary outcome measured using accelerometers, a self-reported questionnaire, and attendance data. Secondary outcomes (e.g., health status) and mediators/moderators (e.g., social support and cohesion) will be assessed with a baseline and follow-up questionnaire. Ethnographic methods will be used to examine how intersecting forms of social inequality shape women's experiences of physical activity and to understand how real-world conditions shape the intervention implementation. The intention-to-treat analysis will employ linear mixed-effects models (LMM) to assess the main intervention effects on physical activity outcomes and other secondary outcomes.
A mineral-fortification system that has a bottle cap, a pouch and a pouch opener. A powder is contained within the pouch, and the powder contains at least one mineral and a redox modulating compound. When the cap is secured onto the opening of a bottle containing a liquid and when the pouch opener is activated, the powder is released from the pouch and mixes with the liquid to form a mineral fortified liquid composition that is fortified with at least one mineral and has a pH between about 2.5 and 9.5. Moreover, the mineral fortified liquid composition has a redox potential that satisfies the following equation:0   RP - (A - B*pH). In this equation RP is the redox potential in millivolts of the mineral-containing liquid composition, pH is the pH of the mineral-containing liquid composition, A is 400 and B is 20. The mineral is preferably selected from calcium, iron, zinc, copper, manganese, iodine, magnesium, and mixtures of these. Moreover, the mineral-fortified liquid composition may preferably be substantially free of flavor or sweetener compounds. Even more preferably, the liquid composition has no metallic taste or after-taste, a Hunter colorimetric ''b'' reading of less than 5.0, and an NTU turbidity value of less than 5.0. The mineral-fortified liquid composition may optionally contain other nutrients and vitamins, for example, vitamin A, vitamin C, vitamin E, niacin, thiamin, vitamin B6, vitamin B2, vitamin B 12, folic acid, selenium, pantathonic acid, and iodine.
Ictal kissing (IK) is a rare type of automatism observed during epileptic seizures. Despite its uncommon occurrence, understanding the underlying mechanisms, the role of emotions, and the level of consciousness during seizures with IK is essential in providing a comprehensive understanding of epilepsy. We describe five cases (.13%) of IK after performing a retrospective analysis of 3794 long-term, ictal video-EEGs from an epilepsy monitoring unit in Mumbai, India. Our patients with drug-resistant epilepsy showed IK had a wide epileptogenic zone. We discuss the current hypotheses on the mechanisms behind IK, the involvement of temporal lobe structures, and the implications of awareness during seizures. The review concludes by suggesting future directions for research to elucidate the complex phenomenon of IK further.
The Illinois Department of Children and Family Services (DCFS) is one of six recipients of the Permanency Innovations Initiative Grant. These funds support the statewide implementation of Trauma Affect Regulation: Guide for Education and Therapy (TARGET) in Illinois. TARGET is a manualized, psycho-educational intervention designed to address complex trauma and difficulties with emotional regulation and relational engagement that occur across a wide range of trauma-related difficulties, including trauma-related and behavioral symptoms. The aim of this intervention is to address the key barriers to permanence for the target population. This population includes youth ages 11-16 who are placed in traditional, relative, and specialized foster homes throughout the state of Illinois, have been in foster care for at least 2 years, and are experiencing mental health challenges and/or at least one placement change. The three key barriers to permanency are: (1) children's need to improve emotional regulation and reduce symptom severity, particularly disruptive behaviors; (2) biological parents' skills in regulating their emotions so they are better able to complete services and address the underlying issues related to their involvement in the child welfare system; (3) foster parents and other placement resources skills in understanding and addressing the needs and disruptive behaviors of the children in their care with trauma histories.

The local evaluation will examine the effectiveness of the TARGET program in increasing permanency rates for foster youth in the target population. The main hypothesis to be tested is that addressing unstable child affect \& behavior secondary to trauma using an intervention that improves both youth modulation skills as well as foster parent capacity to respond appropriately to youth will stabilize placements and improve youth ability to engage with potential permanency resources, thus facilitating progress toward permanence. The evaluation involves randomly assigning eligible foster youth to receive TARGET services or receive services as usual. The evaluators collect proximal and distal outcomes from multiple administrative data sources. Additionally, the evaluation includes the collection of key proximal outcomes through the use of interviews with foster youth, their foster parents and biological parents deemed eligible for participation in the project.
PURPOSE: Impairment of skeletal muscle mass and strength affects 40-70% of patients with active Cushing's syndrome (CS). Glucocorticoid excess sustains muscle atrophy and weakness, while muscle-specific microRNAs (myomiRs) level changes were associated with muscle organization and function perturbation. The aim of the current study is to explore changes in circulating myomiRs in CS patients compared to healthy controls and their involvement in IGFI/PI3K/Akt/mTOR pathway regulation in skeletal muscle.
METHODS: C2C12, mouse myocytes, were exposed to hydrocortisone (HC), and atrophy-related gene expression was investigated by RT-qPCR, WB and IF to assess HC-mediated atrophic signalling. miRNAs were evaluated in HC-treated C2C12 by PCR Arrays. MyomiRs significantly overexpressed in C2C12 were investigated in 37 CS patients and 24 healthy controls serum by RT-qPCR. The anti-anabolic role of circulating miRNAs significantly upregulated in CS patients was explored in C2C12 by investigating the IGFI/PI3K/Akt/mTOR pathway regulation.
RESULTS: HC induced higher expression of atrophy-related genes, miR-133a-3p, miR-122-5p and miR-200b-3p in C2C12 compared to untreated cells. Conversely, the anabolic IGFI/PI3K/Akt/mTOR signalling was reduced and this effect was mediated by miR-133a-3p. In CS patients miR-133a-3p and miR-200b-3p revealed higher circulating levels (p < 0.0001, respectively) compared to controls. ROC curves for miR-133a-3p (AUC 0.823, p < 0.0001) and miR-200b-3p (AUC 0.850, p < 0.0001) demonstrated that both myomiRs represent potential biomarkers to discriminate between CS and healthy subjects. Pearson's correlation analysis revealed that circulating levels of miR-133a-3p are directly correlated with 24 h urinary-free cortisol level (r = 0.468, p = 0.004) in CS patients.
CONCLUSIONS: HC induces atrophic signals by miR-133a-3p overexpression in mouse myocytes and humans. Circulating miR-133a-3p is promising biomarkers of hypercortisolism.
This study was conducted in a single institution. Forty-one (41) nurses were recruited from various units in the medical center. An effort was made to invite nurses from different clinical units, as well as inexperienced and experienced nurses, and males as well as females. To obtain variety in the participants a randomization list (list of names placed in order by a computer) was used to invite nurses. Participants consented and were aware that they would be interviewed three times. The interviews were recorded for transcription and subsequent analysis.
OBJECTIVES: The standard treatment for short bowel syndrome is home parenteral nutrition. Patients' strict adherence to protocols is essential to decrease the risk of complications such as infection or catheter thrombosis. Patient training can even result in complete autonomy in daily care. However, some patients cannot or do not want too much responsibility. However, doctors often encourage them to acquire these skills. Based on qualitative investigations with patients, we wanted to document issues of importance concerning perceptions of autonomy in daily care.
METHODS: Semistructured interviews were conducted with 13 adult patients treated by home parenteral nutrition using a maximum variation sampling strategy. We proceeded to a thematic analysis following an inductive approach.
RESULTS: After achieving clinical management of symptoms, a good quality of life is within the realm of possibility for short bowel syndrome patients with home parenteral nutrition. In this context, achieving autonomy in home parenteral nutrition could be a lever to sustain patients' quality of life by providing better life control. However, counterintuitively, not all patients aim at reducing constraints by reaching autonomy in home parenteral nutrition. First, they appreciate the social contact with the nurses, which is particularly true among patients who live alone. Second, they can feel safer with the nurse's visits. Regaining freedom was the main motivation for patients in the training program and the main benefit for those who were already autonomous.
CONCLUSIONS: Medical teams should consider patients' health locus of control (internal or external) for disease management to support them concerning the choice of autonomy in daily care for parenteral nutrition.
The present invention relates to: a pharmaceutical composition for preventing or treating inflammatory disease accompanying diabetes underlying disease; an information providing method for predicting or diagnosing inflammatory disease accompanying diabetes underlying disease using specific lipid metabolites; and a screening method for a drug for preventing or treating inflammatory disease accompanying diabetes underlying disease using specific lipid metabolites. When treating non-alcoholic fatty liver-induced liver cells with a lactic acid bacteria fermentation product of a Maillard reaction product of whey protein isolate, which is an active component of the present invention, the expression of factors involved in lipid accumulation and apoptosis is effectively reduced, and the production of active oxygen is reduced; and when the fermentation product is orally ingested in a complex disease animal model with both diabetes and inflammatory bowel disease, specific lipid metabolites that show a positive correlation with the induction of colon disease are effectively reduced. Accordingly, the composition of the present invention comprising the fermentation product as an active component can be usefully used as a composition for preventing, alleviating, and treating metabolic disease such as diabetes underlying inflammatory disease and non-alcoholic fatty liver disease. In addition, it is confirmed that lipid metabolites changes after ingestion of the lactic acid bacteria fermentation product of the Maillard reaction product of whey protein isolate in the complex disease animal model with both diabetes and inflammatory bowel disease. Also, it is confirmed that lipid metabolites are highly correlated with the disease. Accordingly, the lipid metabolites can be used to effectively predict the risk of developing inflammatory disease accompanying diabetes underlying disease.
The invention discloses a traditional Chinese medicinal composition for treating constipation. The raw materials comprise, by weight, 25-15 parts of banana peel, 25-15 parts of pear peel, 15-25 parts of grapefruit peel and 20-30 parts of cassia seed. A preparation method is as below: putting the materials into a decoction pot, adding water to cover the raw materials, boiling by strong fire, decocting with small fire fry for about 30 min, and taking the juice. An administration method is as below: once in the morning and evening before meal. Banana peel clears lungs heat, relives polydipsia and clears garbage gut; pear peel reduces fire and promotes the secretion of saliva or body fluid; grapefruit peel regulates qi-flowing for eliminating phlegm, clears the lungs and bowels; and the cassia seed clears the liver fire. The components in the prescription cooperate with each other to reach the effects of reducing fire and promoting the secretion of saliva or body fluid, moistening the intestines and relaxing bowel; and the composition has good curative effects on constipation in the crowd, and is simple to manufacture from easily available raw materials.
Studies have shown that giving donor T cells after a mismatched T cell-depleted stem cell transplant can speed up recovery of T cells in the patient. This approach can cause severe graft versus host disease (GVHD). The purpose of this study is to determine whether giving a donor lymphocyte infusion (DLI) with methotrexate can accelerate immune recovery in recipients of T cell-depleted stem cell transplants. Thirty days after a T-cell depleted transplant, patients will be given a DLI. They will be monitored for immune recovery as measured by CD4 count and for GVHD toxicity.

Patients will be separated into six cohorts based on dose of DLI received: 3 x 10\^4, 4 x 10\^4, 5 x 10\^4, 6 X 10\^4, 8 x 10\^4, and 10 X10\^4 cells/ kg of body weight. A minimum of 3 patients will be tested at each dose starting with the lowest dose. Dose escalation will continue until the dose associated with CD4 count \>100 at Day +120 after transplant without significant GVHD is determined. All patients will receive thirteen doses of methotrexate after the DLI to prevent GVHD. Patients will be followed for 2 years for outcomes.
BACKGROUND & AIMS: Chronic migraine poses a global health burden, particularly affecting young women, and has substantial societal implications. This study aimed to assess the efficacy of Greater Occipital Nerve Block (GONB) in individuals with chronic migraine, focusing on the impact of local anesthetics compared with placebo.
METHODS: A meta-analysis and systematic review were conducted following the PRISMA principles and Cochrane Collaboration methods. Eligible studies included case-control, cohort, and randomized control trials in adults with chronic migraine, adhering to the International Classification of Headache Disorders, third edition (ICHD3). Primary efficacy outcomes included headache frequency, duration, and intensity along with safety assessments.
RESULTS: Literature searches across multiple databases yielded eight studies for qualitative analysis, with five included in the final quantitative analysis. A remarkable reduction in headache intensity and frequency during the first and second months of treatment with GONB using local anesthetics compared to placebo has been reported. The incidence of adverse events did not differ significantly between the intervention and placebo groups.
CONCLUSION: The analysis emphasized the safety and efficacy of GONB, albeit with a cautious interpretation due to the limited number of studies and relatively small sample size. This study advocates for further research exploring various drugs, frequencies, and treatment plans to enhance the robustness and applicability of GONB for chronic migraine management.
Method. A prospective, multicentre, centre randomized ("clusters analysis"), controlled, designed to evaluate the efficacy (reduction of exacerbations) and control degree control (increased ACT score) of an asthma educational program based on a limited intervention in patients with mild to moderate persistent asthma with an ACT \<20. The cases included will be distributed into three arms: the intervention group, who will take the limited educational asthma program; clinical practice group, who will not receive any specific education; and education "gold standard" group, which will receive a formal program of structured and individualized education. 250 cases will be including from 25 Spanish centres (pulmonary and primary care): 10 allocated to the intervention group, 10 clinical practice group, and 5 of the gold standard group. Each centre will enrol 10 patients and will be followed for a year in four programmed visits. At baseline and at follow-up visits, will be collected in each patient: ACT score, the number of emergency room visits, unscheduled visits, hospital admissions, cycles of oral prednisone (\> 15 days), compliance level, spirometric values and daily dose of inhaled corticosteroid (microg. or equivalent per day). Patients in the intervention group will receive the limited educational asthma program, which have three parts: basic information, establishment and revision of a small Action Plan (MiniPlan) and training and review of the inhalation skill of the prescribed device. Educators involved will attend a short workshop (6 h), where they will be trained in the program.
Volleyball is an intermittent sport consisting of short and high-intensity phases where players jump and change direction suddenly. Intense muscle use during training, intense match schedules, short preparation phases and double trainings applied during the day can cause athletes to lose performance and increase injury rates. The performance of the athlete during the season depends on the amount and distribution of the training load and the appropriate recovery intervention applied during the season. Therefore, appropriate recovery interventions for athletes, shortening the recovery period and increasing its quality are very important. Recovery is a process in which the athlete's fatigue after intense training or matches is eliminated, lactic acid in the muscle and blood is removed, energy stores are restored to their previous level and myoglobin oxygenation is provided. One of the parameters used to examine the effects of muscle damage after exercise and to follow recovery is oxygen saturation. It is known that oxygen saturation in the muscle decreases during exercise and increases in the following recovery process. Different interventions are recommended to optimize the recovery of athletes during the season. Cold applications are the most frequently preferred method due to their practicality and accessibility after training as a recovery intervention. Although it has been reported that cold applications have positive effects on fatigue and general perceptual well-being, their effects on acute performance parameters are controversial. In recent years, the use of cold compression applications in the recovery process after training has become widespread in clinics and sports clubs due to the fact that they allow two types of application and are portable and practical. Cold compression devices aim to reduce tissue temperature, reduce pain, control inflammation and accelerate venous return by applying cold and compression simultaneously. This is achieved by continuous circulation of ice water using intermittent pneumatic compression. There are many studies in the literature on the effects of cold applications on performance parameters (no effect or negative effect) and fatigue (reducing muscle pain and fatigue effects). However, the effect of cold compression on recovery at different temperatures has not been determined. Determining the degree of cold applied and the response received, as well as better identifying recovery interventions applied in professional sports environments and developing cold application protocols applied during the post-training recovery process, and investigating the effects of cold compression on fatigue, performance parameters and recovery parameters will contribute significantly to the literature. Therefore, the aim of our study is to examine the effects of different degrees of cold compression applied to professional male volleyball players compared to passive rest on muscle oxygen saturation, fatigue level and performance.
Aim - To investigate the efficacy of super-oxidized solution (SOS) over normal saline in peritonitis. The investigators objectives are to present the potential clinical impact of intraperitoneal lavage with solutions for early recovery of the patient by reducing the infection rate.

Methods - A double-blind random clinical trial was performed in 240 patients diagnosed as peritonitis at MMIMSR, Mullana, Ambala, India, from December 2014 - November 2015. Subjects were divided into 2 groups, i.e. 120 patients in the study group and 120 cases in the control group. Both the groups underwent peritoneal lavage ; the study group received SOS where as control group underwent normal saline lavage. The effectiveness of both the solutions were compared.
PCT No. PCT/EP92/00419 Sec. 371 Date Nov. 10, 1993 Sec. 102(e) Date Nov. 10, 1993 PCT Filed Feb. 27, 1992 PCT Pub. No. WO92/15606 PCT Pub. Date Sep. 17, 1992.In order to isolate an inhibitor of the proliferation of endothelial cells from the tissue of vertebrates the tissue selected as the starting material e.g. embryonic tissue or adult brain tissue from birds or mammals, is centrifuged, homogenized and subsequently the tissue extract is applied to a cation exchanger and the substances which bind to the cation exchanger are subjected to a fractionation, the active fractions are separated by gel filtration chromatography and they are purified by reverse phase HPLC. The new inhibitor obtained in this way is suitable for treating disease states in which an inhibition of capillary growth is necessary such as for the treatment of tumors, rheumatoid arthritis, diabetic retinopathy and retrolental fibroplasia and for treating wounds in order to regulate the regeneration of blood vessels.
PURPOSE:To provide the titled paste consisting of the first component composed of hydroxyapatite, magnesium oxide and an X-ray contrasting material and the second component composed of guaiacol and eucalyptol and useful for the protection and remedy of the root apex lesion in dental treatment. CONSTITUTION:The titled two-pack type paste consists of (A) the first component composed of 40-60wt% (based on the whole weight of the first component) hydroxyapatite, 15-25% magnesium oxide and the remaining part of an X-ray contrasting material (e.g. barium sulfate, bismuth subcarbonate, silver powder, etc.) and (B) the second component composed of 35-60% (based on the whole weight of the second component) guaiacol and the remaining part of eucalyptol. The paste has excellent affinity to living tissue and low irritation to tissue, promotes the cure of the peripheral tissue of root apex and is expected to close the root apex. It is useful also as a restoration material of bone defect. The first component and the second component are kneaded at a rate of 4:1 in use.