anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients who are randomized to this group will receive apixaban 2.5mg twice daily for at least 6 months along with standard intervention, cytoreductive therapy, if applicable. Patients will then be treated and followed up as per standard of care at the discretion of their treating physician after the completion of the study.
A process and apparatus for purifying a protein of interest from a heterogeneous tissue culture fluid mixture is disclosed. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises at least the following steps: (a) Production of a heterogeneous tissue culture fluid mixture containing protein of interest using a continuous perfusion fermentation process. (b) Transfer of the tissue culture fluid mixture to a continuous particle removal process integrated with the continuous perfusion fermentation process. (c) Removal of particulate contaminants from the tissue culture fluid in the continuous particle removal process to produce a clarified tissue culture fluid containing the protein of interest. (d) Transfer of the clarified tissue culture fluid either to a continuous ultrafiltration process or to a surge vessel integrated with the continuous particle removal process. (e) Purification of the protein of interest from the clarified tissue culture fluid wherein the specific flow rate of the mixture through at least the continuous perfusion fermentation process and continuous particle removal process is maintained substantially constant.
Vitamin D supplements are increasingly recommended to curb widespread deficiency. Decreasing the variability in 25OHD responses to supplemental vitamin D would make the supplementation process more predictable, and thereby reduce the number of 25OHD measurements and dose adjustments that are needed to achieve the targeted 25OHD level. This study seeks to identify potential sources of variability in the 25OHD3 response to supplemental vitamin D3 that are plausible based on rat studies, but have not been explored in humans. The investigators hypothesize that the serum 25OHD3 response to supplemental vitamin D3 in healthy adults will be enhanced in the presence of a meal and the enhancement will be greater when the meal is low as opposed to high in fat content. The enhancement will result from increased vitamin D absorption. The investigators will test this hypothesis by pursuing the following aims in a 3-mo trial in which up to 70 healthy men and women will be randomized to one of the following meal conditions under which they will take a monthly oral dose of 50,000 IU of vitamin D3: no meal (fasting), a low fat meal, or an iso-caloric high fat meal. Serum 25OHD3 will be measured at baseline and after 1 and 3 mo. A serum vitamin D3 absorption test will be performed in each subject after the first dose of vitamin D. The Primary Aim is to identify the meal condition (fasting, low-fat, or high-fat meal) under which the 25OHD3 response to supplemental vitamin D3 is greatest and most consistent. The Secondary Aim is to determine whether vitamin D3 absorption is affected by the meal condition and to determine whether the absorption of vitamin D3 predicts the longer-term 25OHD3 response to supplementation.
The Mind programme is an ACT, mindfulness and compassion intervention for women with breast cancer. It will include 8 weekly group sessions, with the duration of 120 minutes each, and will be delivered at the Radiotherapy Service of the CHUC or through an online platform. All participants will continue on receiving the recommended medical treatment for their clinical diagnosis.
Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme, and therefore, selectively interferes with bacterial biosynthesis of nucleic acids and proteins.

Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially Pseudomonas aeruginosa. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.

Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03 mcg/mL trimethoprim and 1 unit/mL polymyxin B.
In the tongue, lip and chin exercise group, patients who are routinely followed up and who will be given additional tongue, lip and jaw exercises training (at least 10 minutes 4 times a day and preferably before meals) will take place. Patients in Tongue, Lip, Chin Exercise Group will do the tongue, lip and chin exercises as recommended for 15 days. At the end of 15 days, all patients will come the second interview. The same data collection methods are repeated after 15 days. content of the training to be given to the tongue, lip and chin exercise group and the exercise brochure to be given to the patients T.C. Oral-Motor Exercises Brochure published by the Ministry of Health Istanbul Provincial Health Directorate, Basic Evaluation Principles in Treatment Movements book and Specialist. It was determined and prepared in line with the recommendations of physiotherapist İbrahim ÖZDEMİR.
The invention discloses a compound guava preparation and a manufacturing method thereof. The preparation is made from guava leaves, twigs of euonymus alatus, ficus hirta, mulberry leaves, kudzuvine roots, rhizoma coptidis, rhizoma atractylodis, rhizoma alismatis, hawthorn fruits and hongqu. The preparation has the efficacy of fortifying the spleen and resolving phlegm, reducing blood glucose and fat, and discharging the turbid and clearing heat, has an obvious effect on reduction of blood glucose, and can improve insulin resistance. In a clinical observation process, and in a compound guava preparation group, only three patients feel slight stomach discomfort and can self-relieve the discomfort without special treatment, and other patients have no untoward reaction. Therefore, the compound guava preparation is an efficient safe orally-administrated blood-glucose reducing medicine. The preparation is simple in formula and manufacturing method, convenient to consume, and suitable for industrial production and can be consumed for a long time.
BACKGROUND: People with traumatic brain injury (TBI) are at high risk for infection and sepsis. The aim of the study was to develop and validate an explainable machine learning(ML) model based on clinical features for early prediction of the risk of sepsis in TBI patients.
METHODS: We enrolled all patients with TBI in the Medical Information Mart for Intensive Care IV database from 2008 to 2019. All patients were randomly divided into a training set (70%) and a test set (30%). The univariate and multivariate regression analyses were used for feature selection. Six ML methods were applied to develop the model. The predictive performance of different models were determined based on the area under the curve (AUC) and calibration curves in the test cohort. In addition, we selected the eICU Collaborative Research Database version 1.2 as the external validation dataset. Finally, we used the Shapley additive interpretation to account for the effects of features attributed to the model.
RESULTS: Of the 1555 patients enrolled in the final cohort, 834 (53.6%) patients developed sepsis after TBI. Six variables were associated with concomitant sepsis and were used to develop ML models. Of the 6 models constructed, the Extreme Gradient Boosting (XGB) model achieved the best performance with an AUC of 0.807 and an accuracy of 74.5% in the internal validation cohort, and an AUC of 0.762 for the external validation. Feature importance analysis revealed that use mechanical ventilation, SAPSII score, use intravenous pressors, blood transfusion on admission, history of diabetes, and presence of post-stroke sequelae were the top six most influential features of the XGB model.
CONCLUSION: As shown in the study, the ML model could be used to predict the occurrence of sepsis in patients with TBI in the intensive care unit.
Probiotic tablets (Periobalance®, Sunstar, Switzerland). Intervention: 30 probiotic tablets were given after the mechanical debridement of implants with mucositis and periimplantitis.
OBJECTIVES: Trans-sacral epiduroscopic laser decompression (SELD), employing a video-guided catheter and laser, is one of the preferred options for minimally invasive treatment in lumbar disc disease. The aim of this study was to evaluate the effect of SELD treatment on pain, disability, and quality of life in patients with lumbar disc herniation.
METHODS: Between January 2015 and June 2017, a total of 76 patients who underwent SELD were examined retrospectively. The Oswestry Disability Index (ODI) and Visual Analog Scale (VAS) scores were recorded preoperatively, as well as 1, 3, 6, and 12 months after SELD. Quality of life was recorded preoperatively and 12 months after SELD. Patient satisfaction was evaluated based on Odom's Criteria at the final follow-up.
RESULTS: Improvement was observed in low back pain and radicular pain, with the VAS score decreasing from 6.5±0.9 and 7.2±0.3 to 2.31±1.6 and 2.9±1.3 at the final follow-up (p<0.001). The rate of disability, assessed by ODI, decreased from 65.21±1.7 to 21.38±1.0 at the final follow-up. SF-36 scores were statistically higher for all sub-variables of the questionnaire after the procedure. At the final follow-up, 65.8% of patients reported a degree of satisfaction as excellent-good based on Odom's Criteria.
CONCLUSION: Trans-sacral epiduroscopic laser decompression enhances quality of life by improving pain and disability scores in patients with chronic low back and/or radicular pain who do not respond to conservative treatments and epidural steroid administration.
PROBLEM TO BE SOLVED: To provide a film, especially a substrate film for pasting which has softness and stretchability, is excellent in a skin following property and printability, and has an effect of prevention of bleeding-out for rubber softener. SOLUTION: The film has a thickness of 20-200 μm and contains 20-200 pts.wt. of polyethylene resin, 5-50 pts.wt. of polypropylene resin, 50-200 pts.wt. of the softener for rubber and 2-20 pts.wt. of hydrocarbon-based wax, per 100 pts.wt. of a hydrogenated block copolymer containing 5-50 wt.% of a polymer block A and having a glass transition temperature of -20 deg.C or lower and a number average molecular weight of 50,000-150,000 as a whole, among the hydrogenated block copolymer obtained by the hydrogenation of a block copolymer having two or more polymer blocks A composed of vinyl aromatic compound and one or more polymer block B composed of a conjugated diene compound in the molecules. The substrate film for pasting comprises this film, and a pasting material is constructed by forming an adhesive layer on the substrate film.
This study investigated the antioxidant and neuroprotective effects of nicotinamide combined with ischemic preconditioning against cerebral ischemia reperfusion (CIR) injury. Thirty-five Wistar albino male rats were randomly divided into five groups: sham, preconditioned ischemia/reperfusion (IP+IR), ischemia/reperfusion (IR), preconditioned ischemia/reperfusion + nicotinamide (IP+IR+N), and ischemia/reperfusion + nicotinamide (IR+N). CIR was achieved with bilateral common carotid artery occlusion. IP+IR and IP+IR+N groups 30 min before ischemia; Three cycles of 10 sec ischemia/30 sec reperfusion followed by 20 min IR were applied. The IP+IR+N and IR+N groups received 500 mg/kg nicotinamide intraperitoneally. After 24 h of reperfusion, a neurological evaluation was performed and vertıcal pole test. Biochemically, malondialdehyde (MDA), glutathione (GSH) levels and catalase (CAT) activity were measured in blood and brain tissue samples. Rates of red neurons, sateliosis and spongiosis were determined histopathologically in the prefrontal cortex areas. After CIR, MDA levels increased significantly in serum and brain tissue in the IR group compared to the sham group, while GSH and CAT activity decreased in the brain tissue (p < 0.05). MDA levels in the tissues were found significantly decreased in the IR+N group compared to the IR group (p < 0.05). Administration of nicotinamide together with IP significantly decreased MDA levels in brain tissue and increased GSH and CAT activity (p < 0.05). Compared to the IR group, the morphological and neurological damage in the prefrontal cortex areas decreased in the IP+IR, IP+IR+N, and IR+N groups (p < 0.05). In addition, red neuron, sateliosis and spongiosis rates increased significantly in the IR group compared to the Sham, IP+IR+N, IR+N groups (p < 0.001 for all). In neurological evaluation, while the neurological score increased and the time on the vertical pole decreased significantly in the IR group, preconditioning, and nicotinamide groups reversed (p < 0.05). The study's results show that nicotinamide administration with ischemic preconditioning alleviates cerebral ischemia/reperfusion injury.
In major craniosynostosis surgery with moderate to severe blood loss, patients may be exposed to multiple donors. We have previously reported a method for reducing donor exposure using mixed pediatric units including plasma. To further reduce donor exposure, we used plasma-free divided pediatric units. The study aimed to investigate the feasibility of the new strategy for reducing donor exposure. This prospective observational study recruited children younger than 1 year who were scheduled for nonsyndromic craniosynostosis surgery. One adult red blood cell unit was divided into 4 equal units on the day before the operation for use intra- or postoperatively. Number of donor exposures, estimated blood loss, crystalloid, colloid, and blood product volumes, and coagulation parameters were evaluated. Nineteen infants were included. The mean estimated blood loss was 19 (3) mL/kg and the transfusion volume was 17 (7) mL/kg. The median donor exposure per patient was 1 (range, 1-3). During surgery, all infants received at least one DPU. Two infants received transfusions from more than one donor during the intraoperative period. In the first 24 hours postoperatively, 14 infants received transfusion; 10 received only DPUs, whereas 4 received from multiple donors. In all, multiple donor exposure was prevented in 14 of 19 infants. Postoperative Pk-INR was 1.33 (0.16); no plasma or platelets were transfused. The plasma-free DPU transfusion protocol may be useful to reduce donor exposure in open craniosynostosis surgery in infants.
Patients in the control arm will only fill out the symptom survey at the time of admission and days 7, 10, and 14. The results of symptom surveys from the patients in the control arm will not be sent to providers, but will be used for data analysis purposes only. The four symptom-specific PROMIS subsets (Anxiety, Depression, Fatigue, and Sleep Disturbance) will be filled out weekly while patients are admitted to the hospital. Patients will again complete the 6 minute walk distance testing, HRQoL surveys, and PASS assessment at the time of discharge. HRQoL (by mail) and PASS (by telephone) will be assessed for a third time 30 days after discharge.
Our viewpoint is that ethanol could act as a molecular messenger in animal and plant organisms under conditions of hypoxia or other stresses and could elicit physiological responses to such conditions. There is evidence that both animal and plant organisms have endogenous levels of ethanol, but reports on the changes induced by this alcohol at physiological levels are sparse. Studies have shown that ethanol has different effects on cell metabolism at low and high concentrations, resembling a hormetic response. Further studies have addressed the potential cellular and molecular mechanisms used by organisms to sense changes in physiological concentrations of ethanol. This article summarizes the possible mechanisms by which ethanol may be sensed, particularly at the cell membrane level. Our analysis shows that current knowledge on this subject is limited. More research is required on the effects of ethanol at very low doses, in plants and animals at both molecular and physiological levels. We believe that further research on this topic could lead to new discoveries in physiology and may even help us understand metabolic adjustments related to climate change. As temperatures rise more frequently, dissolved oxygen levels drop, leading to hypoxic conditions and consequently, an increase in cellular ethanol levels.
The invention provides a new use of sulfonatocarlix(5)arene in preparing a medicine for treating paraquat poisoning. The sulfonatocarlix(5)arene reduces probability of contacts between paraguat and NAD(P)H in vivo by inclusion coordination of the sulfonatocarlix(5)arene and the paraguat, and reduces oxidizing ability of the paraguat, thus inhibiting generation of a free radical (HO<.>) which is poisonous to cells in vivo. Additionally, the lower edge of the sulfonatocarlix(5)arene is rich in phenolic hydroxyl structures which can provide active hydrogen to inactivate the HO<.> free radical. Experiments on mice prove that the sulfonatocarlix(5)arene is nontoxic or low toxic and greatly reduces toxicity of the paraguat. After a mouse is poisoned by orally taking the paraguat (dose: 106.99mg/kg), good curative effect can be achieved by orally taking two-fold sulfonatocarlix(5)arene for once, the total lethality is decreased from 90% to 30%, and the lowest lethality is even decreased to 0%. After a mouse is poisoned, good effect can be achieved by orally taking the sulfonatocarlix(5)arene in two hours after poisoning.
OBJECTIVES: To develop and validate a novel interpretable artificial intelligence (AI) model that integrates radiomic features, deep learning features, and imaging features at multiple semantic levels to predict the prognosis of intracerebral hemorrhage (ICH) patients at 6 months post-onset.
MATERIALS AND METHODS: Retrospectively enrolled 222 patients with ICH for Non-contrast Computed Tomography (NCCT) images and clinical data, who were divided into a training cohort (n = 186, medical center 1) and an external testing cohort (n = 36, medical center 2). Following image preprocessing, the entire hematoma region was segmented by two radiologists as the volume of interest (VOI). Pyradiomics algorithm library was utilized to extract 1762 radiomics features, while a deep convolutional neural network (EfficientnetV2-L) was employed to extract 1000 deep learning features. Additionally, radiologists evaluated imaging features. Based on the three different modalities of features mentioned above, the Random Forest (RF) model was trained, resulting in three models (Radiomics Model, Radiomics-Clinical Model, and DL-Radiomics-Clinical Model). The performance and clinical utility of the models were assessed using the Area Under the Receiver Operating Characteristic Curve (AUC), calibration curve, and Decision Curve Analysis (DCA), with AUC compared using the DeLong test. Furthermore, this study employs three methods, Shapley Additive Explanations (SHAP), Grad-CAM, and Guided Grad-CAM, to conduct a multidimensional interpretability analysis of model decisions.
RESULTS: The Radiomics-Clinical Model and DL-Radiomics-Clinical Model exhibited relatively good predictive performance, with an AUC of 0.86 [95% Confidence Intervals (CI): 0.71, 0.95; P < 0.01] and 0.89 (95% CI: 0.74, 0.97; P < 0.01), respectively, in the external testing cohort.
CONCLUSION: The multimodal explainable AI model proposed in this study can accurately predict the prognosis of ICH. Interpretability methods such as SHAP, Grad-CAM, and Guided Grad-Cam partially address the interpretability limitations of AI models. Integrating multimodal imaging features can effectively improve the performance of the model.
CLINICAL RELEVANCE STATEMENT: Predicting the prognosis of patients with ICH is a key objective in emergency care. Accurate and efficient prognostic tools can effectively prevent, manage, and monitor adverse events in ICH patients, maximizing treatment outcomes.
Women allocated in the donor group will donate their vaginal secretion, which will be processed and analyzed throughy before it is used as a transplant. In total, the donors will each provide approximately 10 donations of vaginal secretion.
INTRODUCTION: This study examines the therapeutic efficacy of polynucleotide-based therapies, specifically REJURAN®, for managing scars and burns. Scars and burns present significant challenges in dermatology, often affecting patients' quality of life. Traditional treatments can be limited in effectiveness, prompting the exploration of innovative approaches like polynucleotide therapy, which utilizes salmon DNA to stimulate tissue repair, modulate inflammation, and enhance collagen production.
METHODS: A series of case studies was conducted, including diverse patient profiles with various types of scars and burns. The study evaluated the impact of REJURAN® on scar appearance, texture, and overall skin quality. Some cases also explored the combination of polynucleotide therapy with other treatments such as Platelet-Rich Plasma (PRP) and botulinum toxin.
RESULTS: Notable improvements were observed across cases, including reduced scar visibility and enhanced skin texture. The therapy proved effective in treating post-traumatic, post-operative, and burn-related scars, demonstrating its versatility and potential benefits. Combination therapies showed promising results, though further research is needed.
CONCLUSION: Polynucleotide-based therapy with REJURAN® shows promise in scar and burn management, offering a novel approach that leverages the body's regenerative processes. Further studies are recommended to confirm these findings and refine treatment protocols.