anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cancer metastasis is one of the most important factors determining the prognosis of cancer patients and is the main process that determines death caused by cancer. In cancer therapies such as surgery, radiotherapy, chemotherapy and the like, a lot of efforts have been made to improve the survival of patients. The field of studying cancer metastasis is one of the last strategies to overcome cancer, and studies on cancer metastasis suppressors are essential for developing metastasis-suppressing drugs. Brain metastases are more common than primary CNS tumors and confer grave prognosis on patients, with a median survival of less than one year. Malignant melanoma is the deadliest skin cancer with rising incidence worldwide. Melanoma frequently metastasizes to the lungs, bone, liver and brain. Although the development of targeted therapies and immune checkpoint inhibitors has dramatically improved patient overall survival, brain metastases still pose an unmet clinical challenge. The microenvironment plays a crucial role in facilitating metastasis by promoting survival, colonization and proliferation of disseminated tumor cells to distant organs. Astrocytes are key components of the brain microenvironment. Neuroinflammation is a prominent feature of reactive astrocytes, characterized by the release of pro-inflammatory cytokines, increased blood-brain barrier permeability and immune cell infiltration, and is also a hallmark of brain metastatic niche formation. The mechanisms underlying survival and colonization of metastatic melanoma cells in the brain are poorly understood. Accordingly, there is a great need in the art to identify therapeutic interventions to treat brain metastases.
Anesthesiologists still rely on use of a conventional stethoscope to detect abnormal breath sounds during and after surgery - this process is labor intensive, intermittent, relies on human experience and thus is highly subjective. In fact, even for the most basic assessments, e.g. endobronchial intubation, human auscultation is unreliable.1 Digital stethoscopes are able to both amplify and digitize airway sounds and also provide a mechanism to record and analyze them for features undetectable by a human. Several small, pilot studies have shown that acoustic waveforms from the lungs produce characteristic spectral patterns in specific pulmonary pathophysiologic states. At this time, there are no studies that examine the acoustic patterns specific to perioperative wheezing or lung re-expansion. With the aid of computerized sound analysis, digital acoustic monitoring could provide a more sensitive, specific, and quantifiable indicator for perioperative respiratory abnormalities including wheezing. It is probable that the digital stethoscope has utility in the detection and monitoring of acoustic changes characteristic of turbulent respiratory gas flow due to wheezing and/or the incomplete resolution of atelectasis following the re-initiation of ventilation in a collapsed lung. In addition, treatment of perioperative wheezing with an inhaled bronchodilator may lead to resolution of wheezing and this response to treatment may also be monitored using waveform and spectral characteristics of the acoustic patterns from the digital stethoscope.
The present invention discloses antisense nucleic acid which can inhibit activity of telomerase of leukemia cells. The sequence of the present invention is 5'-TACGCCCTTCTCAGTTAGGG-3'. The antisense nucleic acid is used for preparing medicine for treating leukemia. The activity of telomerase of leukemia cells can be greatly reduced. The antisense nucleic acid can be matched with cisplatin to prepare medicine for treating leukemia. After the activity of the telomerase is reduced, the sensitivity for the cisplatin is increased, and the function of promoting apoptosis for the cisplatin is strengthened.
BACKGROUND: Post-operative colorectal venous thromboembolism (VTE) rates range between 1 and 3%. Often, surgeons utilize risk assessment models, like the modified Caprini, to determine need for prophylaxis. However, studies reveal additional unaccounted risk factors like preoperative serum albumin level, perioperative blood transfusion, emergency surgery, and preoperative steroid use.
METHODS: This was a multicenter, retrospective study conducted between January 2021-December 2021. The primary endpoint was to assess the VTE rate within 30 days post-operatively.
RESULTS: Overall, incidence rate was 1.75%. Of these, 53% underwent urgent/emergent surgery and 60% had perioperative blood transfusions. Twelve patients had a known preoperative serum albumin level, with 66% being less than 3.5 ​g/dL. Only 30% of patients had a high Caprini risk score. No patient had preoperative steroid use.
CONCLUSION: The study suggests considering urgent/emergent surgeries, low preoperative albumin levels, and blood transfusions for enhanced VTE screening and prophylaxis in post-operative colorectal patients.
We capitalized on the respiratory bodily illusion that we discovered in a previous study and called 'Embreathment' where we showed that breathing modulates corporeal awareness in men. Despite the relevance of the issue, no such studies are available in women. To bridge this gap, we tested whether the synchronization of avatar-participant respiration patterns influenced females' bodily awareness. We collected cardiac and respiratory interoceptive measures, administered body (dis)satisfaction questionnaires, and tracked participants' menstrual cycles via a mobile app. Our approach allowed us to characterize the 'Embreathment' illusion in women, and explore the relationships between menstrual cycle, interoception and body image. We found that breathing was as crucial as visual appearance in eliciting feelings of ownership and held greater significance than any other cue with respect to body agency in both women and men. Moreover, a positive correlation between menstrual cycle days and body image concerns, and a negative correlation between interoceptive sensibility and body dissatisfaction were found, confirming that women's body dissatisfaction arises during the last days of menstrual cycle and is associated with interoception. These findings have potential implications for corporeal awareness alterations in clinical conditions like eating disorders and schizophrenia.
Disclosed is a method for producing natural toothpaste. The method for producing toothpaste using a natural material comprises the following steps: adding refined water in green clay, and leaving the green clay and refined water for a predetermined period of time without being mixed with each other, so the refined water is permeated in the green clay; mixing and agitating the green clay and refined water, when the predetermined period of time passes; adding glycerin into the agitated mixture and re-agitating so as to prevent the agitated mixture from being hardened in process of time; and adding and mixing vegetable oil in the re-agitated mixture. The green clay is 50 to 60% with respect to the total content, and the refined water is 35 to 40% with respect to the total content. A ratio of the green clay and the refined water is 1.3 versus 1 to 1.5 versus 1, and the predetermined period of time is 2 to 3 hours. Accordingly, toothpaste may be produced by using only a natural material without using a chemical synthetic material, so the inside of the oral cavity is cleanly maintained and occurrence of bad breath or inflammation may be prevented. Also, viscosity of toothpaste may be particularly maintained, so the toothpaste may be easily carried and may be mass-produced.
PROBLEM TO BE SOLVED: To obtain a skin protecting agent consisting of a neutral solution of a chitosan, good in feeling in use and high in safety, while holding a humidity maintaining property. SOLUTION: This skin protecting agent is obtained by dissolving a highly deacetylated chitosan, preferably a squid chitosan having >=75% deacetylation ratio, with 0.01-5wt.% organic acid buffer solution (e.g.; glutamic acid) and then neutralizing with the addition of an aqueous alkaline solution (e.g.; NaOH) to prepare a preparation fitted to pH4.5-6.5. It is prepared as a lotion, cream, etc. In contrast to the chitosan derived from a crab or a shrimp induces an allergy, the squid chitosan does not induce the allergy and is preferable in view of its safety. The chitosan as an inexpensive natural polymer is used as an industrial waste water treating agent, a growth promoter for agricultural products, a covering membrane for an injured skin, etc.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by a high metastatic potential with an overall survival rate of ~5%. The transcription factor signal transducer and activator of transcription 3 (STAT3) is overexpressed by >50% of tumors, including SCLC, but its role in SCLC development and metastasis is unclear. Here, we show that, while STAT3 deletion restricts primary tumor growth, it paradoxically enhances metastatic spread by promoting immune evasion. This occurs because STAT3 is crucial for maintaining the immune sensor stimulator of interferon (IFN) genes (STING). Without STAT3, the cyclic adenosine monophosphate-guanosine monophosphate synthase-STING pathway is inactive, resulting in decreased type I IFN secretion and an IFN gene signature. Importantly, restoration of IFN signaling through re-expression of endogenous STING, enforced expression of IFN response factor 7 or administration of recombinant type I IFN re-established antitumor immunity, inhibiting metastatic SCLC in vivo. These data show the potential of augmenting the innate immune response to block metastatic SCLC.
BACKGROUND: A novel risk prediction model appears to be urgently required to improve the assessment of thrombotic risk in overweight patients with nonvalvular atrial fibrillation (NVAF). We developed a novel body mass index (BMI)-based thromboembolic risk score (namely AB2S score) for these patients.
METHODS: A total of 952 overweight patients with NVAF were retrospectively enrolled in this study with a 12-month follow-up. The primary endpoint was 1-year systemic thromboembolism and the time to thrombosis (TTT). The candidate risk variables identified by logistic regression analysis were included in the final nomogram model to construct AB2S score. The measures of model fit were evaluated using area under the curve (AUC), C-statistic, and calibration curve. The performance comparison of the AB2S score to the CHADS2 and CHA2DS2-VASc score was performed in terms of the AUC and decision analysis curve (DAC).
RESULTS: The AB2S score was constructed using 7 candidate risk variables, including a 3-category BMI (25 to 30, 30 to 34, or ≥35 kg/m2). It yielded a c-index of 0.885 (95% CI, 0.814-0.954) and an AUC of 0.885 (95% CI, 0.815-0.955) for predicting 1-year systemic thromboembolism in patients with NVAF. Compared to the CHADS2 score and CHA2DS2-VASc score, the AB2S score had greater AUC and DAC values in predicting the thromboembolic risk and better risk stratification in TTT (P <.0001, P =.082, respectively).
CONCLUSION: Our results highlighted the importance of a BMI-based AB2S score in determining systemic thromboembolism risk in overweight patients with NVAF, which may aid in decision-making for these patients to balance the effectiveness of anticoagulation from the underlying thrombotic risk.
A medical information retrieval system comprises a natural language processing system that processes a vocal user query to identify key words and phrases. These key words and phrases are provided to an inferencing engine that provides a set of knowledge-based inferences from medical knowledge sources, based on these key words and phrases. Thereafter, these knowledge-based inferences are provided to an information retrieval engine that retrieves a corresponding plurality of medical articles based on these knowledge-based inferences, and ranks each with respect to the knowledge-based inferences. A summary engine receives the ranked articles and creates a model based on the topical keywords and candidate sentences found in the highly ranked articles. A paraphrase engine processes the candidate sentences to provide a summary response based on a knowledge-based paraphrase model. An audio output device renders the summary report as the response to the user's original vocal query.
An endermic nutrient material comprising as an effective component a saponified product of docosahexaenoic acid and/or a derivative thereof. A cosmetic composition containing such an endermic nutrient material is also disclosed. The cosmetic composition comprises i) at least one cosmetic component selected from fats and oils, waxes, hydrocarbons, higher fatty acids, alcohols, inorganic salts, dyes, pigments, perfumes, antiseptics and antioxidants, and ii) the saponified product of DHA and/or a derivative thereof, contained in an amount of 0.1% to 50% by weight. 
     The endermic nutrient material has the characteristic of permeating the skin and being absorbed therein, and being not liable to be oxidized. Hence, when cosmetics containing this endermic nutrient material are, for example, rubbed into the skin, it is possible for the DHA to be absorbed in human bodies by everyday and simple application, so that it can be expected to have an effect of various physiological activities possessed by the DHA and/or derivatives thereof and an effect of treating psoriasis and atopic dermatosis. A velvety and moist feel can also be imparted to the skin. Any fish odor undesirable for cosmetics can also be prevented.
BACKGROUND: Traumatic hemorrhagic shock (THS) is a complex pathophysiological process resulting in multiple organ failure. Intestinal barrier dysfunction is one of the mechanisms implicated in multiple organ failure. The present study aimed to explore the regulatory role of mitogen-activated protein kinase kinase 3 (MKK3) in THS-induced intestinal injury and to elucidate its potential mechanism.
METHODS: Rats were subjected to trauma and hemorrhage to establish a THS animal model. MKK3-targeted lentiviral vectors were injected via the tail vein 72 h before modeling. Twelve hours post-modeling, the mean arterial pressure (MAP) and heart rate (HR) were monitored, and histological injury to the intestine was assessed via H&E staining and transmission electron microscopy. Mitochondrial function and mitochondrial reactive oxygen species (ROS) were evaluated. IEC-6 cells were exposed to hypoxia to mimic intestinal injury following THS in vitro.
RESULTS: MKK3 deficiency alleviated intestinal injury and restored mitochondrial function in intestinal tissues from THS-induced rats and hypoxia-treated IEC-6 cells. In addition, MKK3 deficiency promoted Sirt1/PGC-1α-mediated mitochondrial biogenesis and restricted Pink1/Parkin-mediated mitophagy in the injured intestine and IEC-6 cells. Furthermore, the protective effect of MKK3 knockdown against hypoxia-induced mitochondrial damage was strengthened upon simultaneous LC3B/Pink1/Parkin knockdown or weakened upon simultaneous Sirt1 knockdown.
CONCLUSION: MKK3 deficiency protected against intestinal injury induced by THS by promoting mitochondrial biogenesis and restricting excessive mitophagy.
Provided are metal oxide ceramic materials and intermediate materials thereof (e.g., nanozirconia gels, nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental articles). The nanozirconia gels are formable gels. Also provided are methods of making and using the metal oxide materials and intermediate materials. The nanozirconia gels can be made using, for example, osmotic processing. The nanozirconia gels can be used to make nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental article. The nanozirconia green bodies, pre-sintered ceramic bodies, zirconia dental ceramic materials, and dental articles have desirable properties (e.g., optical properties and mechanical properties).
Oxidative stress, defined as an imbalance between pro and antioxidant molecular species in favor of the former, has recently been recognized as a potential mechanism in the peripheral muscle dysfunction associated with COPD. a series of studies are proposed to better understand the role and source of oxidative stress in the skeletal muscle of patients with COPD. Specifically, three main aims will address the following questions regarding COPD, skeletal muscle, and oxidative stress: where is oxidative stress most prevalent, why does oxidative stress occur, and what are the consequences of oxidative stress in COPD? the overall hypothesis to be tested is that COPD results in a shift toward greater intramuscular oxidative stress and this is, at least in part, responsible for the diminished mechanical efficiency and greater peripheral muscle fatiguability during muscular work often associated with this disease. The vascular consequence of this augmented free radical load is altered vascular function and a disruption of the local matching of perfusion and metabolism in skeletal muscle during exercise. These crucial changes result in a cascade of factors such as local hypoxia and elevated vascular shear stress, entering a vicious cycle that leads to the generation of more free radicals, especially during physical work. It is proposed that this imbalance between pro and antioxidant potential, toward oxidative stress, plays a significant role in the attenuated exercise capacity and reduced muscle fatigue resistance associated with COPD.
1395563 5-Nitrofuryl-pyridine derivatives BOEHRINGER INGELHEIM GmbH 22 Sept 1972 [22 Sept 1971] 44054/72 Heading C2C Novel compounds I in which A is Cl, OH, 1-10C alkoxy, or dimethyl- or diethyl-aminoethoxy; R is H, 1-4C alkyl or a pyridyl or phenyl group which may be substituted by Cl, OH, NO 2 ; and the pyridyl moiety is substituted in either the 2- or the 4-position by the 5-nitrofuryl moiety are prepared by nitrating a compound II Compounds V are prepared by condensation of compounds III with compounds IV in which X is halogen or by reaction of compounds III with compounds VI (in which R<SP>1</SP> is CH 3 or C 2 H 5 and X is halogen) in the presence of ammonium acetate. Compounds VIII or VIIIa are prepared by reaction of compounds VI with compounds VII (in which Z is secondary amino) in the presence of ammonium acetate. Compounds X or Xa are prepared by reaction of compounds IX with compounds IV or VI in the presence of ammonium acetate. Compounds XII or XIIa are prepared by reaction of compounds XI (in which R 2 is as R, but is not H or pyridyl) with compounds IV or VI in the presence of ammonium acetate. Compounds XIII are prepared by chlorination of compounds IIa or IIb. Compounds XIV are prepared by reaction of compounds XIII with an alkali metal alkoxide R<SP>3</SP>OM (in which R<SP>3</SP> is 1-10C alkyl or a diethyl- or dimethylaminoethyl group and M is an alkali metal). Pharmaceutical compositions having antimicrobial activity comprise a compound I or a suitable salt thereof (if the compound I has a basic nitrogen atom) in associated with a carrier or diluent and may be administered orally, topically, parenterally, rectally or enterally.
[GB1395563A]
With combination antiretroviral therapy, HIV/AIDS has been transformed from a progressive, usually fatal infection to a manageable chronic condition. Yet, HIV associated neurocognitive disorders (HAND) pose a significant clinical problem, even among patients with controlled HIV viremia. There is evidence of accelerated vascular aging and other vascular disorders in HIV-infected (HIV+) people, and studies suggest an association between vascular disorders and unfavorable neurocognitive outcomes. Thus, one possible contributing factor to the high rates of HANDs and depression could be vascular dysfunction, similar to vascular depression and vascular dementia that occur in elderly non-HIV+ individuals. One commonly used diagnostic marker of vasculopathy is thickening of the vessel wall. Multiple studies have already established the correlation between vessel wall thickening and vascular disease manifestations. This prospective observational study aims to examine the relationships between neurocognitive and depression outcomes and vessel wall thickness as a marker of vascular disease in HIV+ adults. We will be using neuropsychological testing, brain imaging, blood biomarkers, and state-of-the-art high-resolution MR imaging of the carotid vessel walls. HIV infected patients (n=40) and HIV-negative controls (n=40) will be recruited. Participants who consent to longitudinal follow-up will be followed for two years with clinical evaluations every 6 months and repeat imaging studies at 12 and 24 months. Cross sectional data analysis will compare markers of vascular and neurocognitive disorders between HIV-infected and HIV-negative participants. The longitudinal data analysis will assess and compare the temporal progression of vascular disease (imaging and blood biomarker findings) in relation to changes in neurocognitive and depression scores in both groups.
PURPOSE: A composition containing socheongryong tang(kind of oriental medicine) and lactic acid bacteria-fermented socheongryong tang is provided to protect liver cells from cytotoxicity due to oxidative stress and tBHP, and to be used as a pharmaceutical composition or a health functional food for preventing and treating disorders by hepatotoxicity. CONSTITUTION: A pharmaceutical composition for preventing and treating disorders by hepatotoxicity contains socheongryong tang and/or lactic acid bacteria-fermented socheongryong tang. The lactic acid bacteria are selected from the group consisting of Bipidobacterium, Lactobacillus, Streptococcus, Leuconostoc, Pediococcus, and Lactococcus. A method for preparing the fermented socheongryong tang comprises: a step of mixing crude drug materials including Ephedrae herba, Paeonia lactiflora, Asarum sieboldii, Zingiberis rhizoma, Glycyrrhiza uralensis fischer, Cinnamomi ramulus, Pinellia ternate, and Schisandra chinensis (Turcz.) Baill, and extracting by hot water to prepare socheongryong tang; a step of inoculating lactic acid bacteria mycelium to socheongryong tang and preparing a culture liquid; and a step of fermenting the culture liquid. A health functional food for preventing and treating disorders by hepatotoxicity contains socheongryong tang and/or lactic acid-fermented socheongryong tang.
The Acceptance and Commitment Therapy + MTAU consists of an unpublished manual developed for the purposes of the project (Karekla et al., 2013). The 8, 90-min weekly group sessions focus in fostering psychological flexibility or the capacity to engage or change behaviors based on what a situation affords and an individual's goals, needs, and desires (Hayes et al., 2004). The ACT protocol involves helping patients to engage in values-based behaviors while remain in contact with pain, especially, when efforts to control or reduce it fail or contribute to suffering.