anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Chronic shoulder and neck pain is one of the most common chronic occupational disorders, with an average incidence rate of 48.5%, severely affecting patients' quality of life and ability to work. According to epidemiological research, the prevalence of chronic neck, shoulder, and low back pain in adults over the age of 45 ranges from 40 to 80%. According to reports, medical staff have a higher incidence rate than other populations, and there is a positive correlation between the grade of the medical institution and the incidence rate, making medical staff a priority group for the prevention of chronic neck, shoulder, and low back pain. By the end of 2022, China has been fully opened to epidemic prevention and control, the total number of patients in domestic hospitals has increased significantly, and resulting in medical personnel shoulting great pressure, which seriously affects the physical and mental health of medical personnel. The aim of this study was to explore the risk factors of chronic neck, shoulder and lumbar back pain in medical staff. To provide guidelines for medical staff to improve cervical and lumbar subacute pain and reduce the emergence of spinal lesions.
METHODS: From January to February 2023, 602 staff members of a third-grade hospital in Zunyi City were studied by Questionnaire star. Univariate and multivariate Logistic regression were used to analyze the independent risk factors of chronic neck, shoulder and lumbar back pain in medical staff, with stepwise regression utilized to choose the optimum model. The model was selected using Akaike's information criterion (AIC) and the Hosmer-Lemeshow goodness-of-fit test.
RESULTS: A total of 602 medical staff were polled, and the findings revealed that 588 cases of chronic neck, shoulder, and low back pain of varied severity had occurred in the previous 1 to 2 years, with a 97.7% incidence rate; logistic regression analysis revealed that anxiety level, frequency of bending over in the previous 1 to 2 years, whether related preventive measures were taken at work, gender, positive senior title, daily ambulation time, and whether the department they worked in organized independent influencing factors.
CONCLUSION: The incidence of chronic neck, shoulder, and lumbar back pain among medical staff is high; its influencing factors are different and have not been systematically identified. Hospitals should take effective measures tailored to local conditions to improve the physical and mental health of medical staff.
Childhood hearing loss has substantial lifelong consequences, including speech-language delay, worse academic performance, and limited vocational opportunities. In rural settings, where access to care is limited, school-based preventative screening programs can help in early identification of childhood hearing loss. The state of Kentucky mandates hearing screening for all schools; however, the effectiveness of these programs is unclear. Further, current school programs do not include a middle ear assessment, which is needed to detect infection-related hearing loss common in children in rural and low-income settings. In children referred from school-based hearing screening programs, loss to follow-up also remains a pervasive issue.

To address these key issues, the University of Kentucky has partnered with the University of Arkansas Medical Sciences to lead the Appalachian STAR trial. This trial will evaluate a multilevel intervention (STAR model) that combines mobile health (mHealth) hearing screening tools with telemedicine technology for specialty care access in rural Kentucky schools. An initial version of the model was used in rural Alaska where telemedicine-based specialty referral improved both proportion of children receiving follow-up and time to follow-up. The refined STAR model will utilize an enhanced mHealth screening protocol that includes tympanometry for the detection of middle ear disease. The STAR model will also include a specialty telemedicine referral process in schools for children who refer school screening.

The Appalachian STAR stepped-wedge cluster randomized trial will be conducted in approximately 64 elementary schools located in 14 counties in rural Kentucky. Approximately 3600 students at school entry will be enrolled annually for 4 years, for a total of approximately 14,400 children. Cluster randomization will occur in two sequences at the county level, with 7 counties (clusters) in each sequence. The 4-year trial will include a control condition period, followed by phased roll-out of the intervention. The enhanced mHealth school hearing screening protocol will be implemented first. The following year, specialty telemedicine referral will be added to the enhanced screening protocol. All 14 counties will receive the STAR model by the end of the trial. An implementation evaluation will be conducted to refine the STAR model throughout the trial. If successful, the STAR model could be applied to address hearing loss and other childhood health conditions that affect underserved rural communities across America.
PURPOSE:The titled vaccin for oral administration that contains, as an antigen, cell bodies of periodontosis-causative bacterium or their cillia or extract. CONSTITUTION:The objective vaccin for preventing periodontosis is obtained by using, as an antigen, the whole cell bodies of periodontosis causative bacteria, preferably bacteriodes gingivalis and Actimonyces viscosus or their cillia or their extract. When it is given orally, the fixation of the bacteria causing periodontosis is prevented to inhibit their proliferation. This prevention is higher in safety than parenteral administration. The dose of the somatic antigen is 0.1-10ml of the vaccin containing 10<4>-10<10>/ml of the whole cell bodies and is given continuously for 3-15 days. Fimbrila antigen and extract antigen are given, respectively, 0.1-10ml of 0.01-10mg/ml concentratin for 3-15 days.
HIV is a virus that can lead to acquired immunodeficiency syndrome (AIDS), a disease that breaks down the immune system and allows for entry of life-threatening secondary infections. HIV is a major global health concern, with countries in Africa undergoing a severe HIV/AIDS crisis. The number of new cases of HIV infection in Africa continues to rise, making disease prevention methods imperative. Important to the prevention process are early testing, educational counseling on HIV and how to reduce sexual-risk behavior, and connecting people with HIV infection to services that offer medical treatment and social support. However, the most effective strategy for fully integrating HIV counseling, testing, and medical care access is not known. This study will compare the effectiveness of brief versus detailed HIV counseling sessions, paired with either referrals to HIV-specific medical care or usual care, in reducing HIV risk behavior and in increasing treatment adherence in Uganda.

Participation in this study will last 12 months. All participants will undergo an initial interview to obtain basic information on previous HIV testing and status. Participants will then be assigned randomly to receive a brief or more detailed counseling session given before and after HIV testing. Participants assigned to the brief counseling session will receive 10 to 15 minutes of pretest counseling on the importance of HIV testing and available services for people infected with HIV. Participants assigned to the detailed counseling session will receive 45 to 60 minutes of pretest counseling on general HIV/AIDS information and testing for HIV. After pretest counseling, participants in both groups will undergo a blood draw for HIV testing. All participants will receive test results and additional counseling 1 hour after the blood sample is drawn.

Participants who are found to be infected with HIV will be assigned randomly to receive enhanced referrals to HIV-specific medical care or referrals to usual care. Participants receiving the enhanced referrals will be provided with more detailed counseling on how to access HIV services, will be introduced to a specific HIV clinic, and will be given a list of other HIV services available in the area. After leaving the hospital, participants will receive reminder telephone calls 1 week before their first scheduled visits at the HIV clinics. Participants receiving referrals to usual care will be provided with information on the importance of receiving HIV care and will be given a list of available HIV area services. At Months 3, 6, 9, and 12, participants in both groups will be interviewed about contact information, overall health, current medications, sexual history, health services utilized, and any repeat HIV tests. Participants who are not infected with HIV may be randomly selected to undergo the same follow-up interviews as the HIV infected participants.
The invention discloses a micro-filtration and ultra-filtration combined efficient green purification technology for ganoderma lucidum polysaccharide. A ganoderma lucidum polysaccharide solution extracted by ultrasonic is used as an experimental material, and the extract is micro-filtered with meshes of 0.2 micron to remove impurities such as organic colloid and mechanical particles. The micro-filtered permeate is ultra-filtered, the liquid is delivered to the surface of a membrane (50kDa and the area of the membrane is 0.1m<2>) by a peristaltic pump to flow tangentially, the filtrate is collected, and the intercepted liquid is refluxed to a liquid storage tank; when the liquid is concentrated to about one fourth of volume, the ultra-filtration process is finished; and (95 percent) ethanol in a volume which is 4 times that of the liquid is used for precipitation, freeze-drying and weighing are carried out. The experimental conditions comprise that the temperature is 35 DEG C; in the operating pressure, the inlet pressure is 0.82bar, and the outlet pressure is 0.68bar; and the trans-membrane pressure difference delta P is equal to (0.82+0.68)/2 and equal to 0.75bar. The purity of the ultra-filtered ganoderma lucidum polysaccharide reaches 61.32 percent, and concentration and purification processes of the ganoderma lucidum polysaccharide are greatly simplified. The obtained ganoderma lucidum polysaccharide can be widely applied to a base material for medicaments and health-care food.
All women attending our prenatal clinic will be invited to participate in this research study. Participants will complete two short questionnaires during their first visit to our prenatal clinic and be tested for Hepatitis C. Women who test positive for Hepatitis C will be carefully followed during their pregnancies and will have viral load tests and liver function tests during each trimester, at delivery and six weeks after their babies are born. All women testing positive for Hepatitis C will be referred to a hepatologist (a liver specialist) after delivery and their babies will be referred to a pediatrician for further follow-up and care. Based on previous studies we are concerned that some women may never know that they are carriers unless their blood is checked for the virus. Currently testing for Hepatitis C during pregnancy is not routinely done.

The results of this study will help us to find out how many women attending our prenatal clinic test positive for Hepatitis C and how many cases would have been missed if we only relied on one of the questionnaires to decide whether to do the blood test or not. (The questionnaire deals with factors that could put a person at risk for acquiring Hepatitis C). By following our Hepatitis C positive pregnant patients throughout their pregnancies, deliveries and after their babies are born we will learn more about how the virus changes during pregnancy. The type of deliveries, any complications and the overall state of health of the Hepatitis C positive mothers participating in this study will be reported. We will also be able to report on the number of babies who are born with the virus and the state of their health up to six months of age.
Approximately 24 women that are experienced in breastfeeding will be recruited to serve in the role of breastfeeding peer counselors. These women will assess usability and acceptability of mobile health (mHealth) education tools designed following a series of focus groups for the project, Breastfeeding Education Support Tool for Baby. The mHealth tools will be used during the training and education of the peer counselor subjects. Following appropriate modification, some of the mHealth tools will be used with a total of approximately 120 women recruited late in pregnancy for initial breastfeeding counseling before delivery and the subsequent provision, for at least 6 months post-delivery, of home visits for peer counseling and education that integrates use of mHealth tools. Peer counselors and research staff will gather data from mothers receiving the intervention about breastfeeding experiences and outcomes, including breastfeeding continuation after initiation, exclusivity for 6 months of an infant's life, and breastfeeding duration. This data will be compared to data obtained through surveys administered to a control group of approximately 120 maternal subjects that received standard pre- and post-delivery care but not the study intervention of peer counseling and education using mHealth tools.
The present invention provides a wound healing material and a preparation method thereof. The wound healing material provided by the invention is a hydrogel type wound healing material formed by chitosan, gamma-polyglutamic acid and heparin by electrostatic interaction, wherein the mass percent ratio of chitosan to gamma-polyglutamic acid to heparin is 2.94 to (1.03-1.86) to (0.20-1.03). The wound healing material both has good hygroscopicity and excellent mechanical properties. Moreover, the preparation method is simple and convenient, and the practicability is strong. The hydrogel type wound healing material prepared by the method provided by the invention has good biological compatibility and drug carrying ability, as well as stronger mechanical strength. Besides being applied to wound dressing, the wound healing material can also be applied to tissue engineering scaffold materials for cartilage repair, drug carriers and other aspects, thereby having a broad application prospect.
BACKGROUND: Circadian health refers to individuals' well-being and balance in terms of their circadian rhythm. It is influenced by external cues. In adults, a close relationship between circadian-related alterations and obesity has been described. However, studies in children are scarce, and circadian health and its association with obesity have not been evaluated globally. We aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score (GCS) in a school-age population.
METHODS: Four hundred and thirty-two children (7-12 years) were recruited in Spain. Non-invasive tools were used to calculate the GCS: (1) 7-day rhythm of wrist temperature (T), activity (A), position (P), an integrative variable that combines T, A, and P (TAP); (2) cortisol; and (3) 7-day food and sleep records. Body mass index, body fat percentage, waist circumference (WC), melatonin concentration, and cardiometabolic marker levels were determined.
RESULTS: Circadian health, as assessed by the GCS, differed among children with obesity, overweight, and normal weight, with poorer circadian health among children with obesity. Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health, respectively, than did those with normal weight or low WC. The percentage of rhythmicity, a marker of the robustness of the TAP rhythm, and the amplitude, both components of the GCS, decreased with increasing obesity. Different lifestyle behaviors were involved in the association between circadian health and obesity, particularly protein intake (P = 0.024), physical activity level (P = 0.076) and chronotype (P = 0.029).
CONCLUSIONS: The GCS can capture the relationship between circadian health and obesity in school-age children. Protein intake, physical activity level, and chronotype were involved in this association. Early intervention based on improving circadian health may help to prevent childhood obesity.
Procedure and apparatus for the production of non- biological vectors for transport of substances by turbulent coaxial injection. The procedure consists in the coaxial injection of two phases of different polarity into which the substance is incorporated. The procedure uses an apparatus which consists of a mixing vessel 1, a high-speed shaker 2, temperature sensors 3, means for evacuation of the dispersion obtained 4, a coaxial injector 5, which receives the different phases via a T-shaped connecting piece 6, heated pipes carrying the phases to be injected 7, systems for pumping the phases 8, a centering device 9, and thermostats 10. The procedure and the apparatus used therein are useful for preparing nanoparticles, nanospheres, microparticles and liposomes. They have applications in the pharmaceutical, cosmetic, food and dyeing industries, etc. <IMAGE>
The present invention relates to a composition for skin whitening and skin protection comprising stilbenes and/or extracts containing stilbenes obtained from plants of the dendrobium genus (such as dendrobium officinale, dendrobium nobile, etc.) and its use in managing melanogenesis, skin darkening and skin aging. More specifically, the present invention relates to the use of dendrobe components and stilbenes for reducing melanin formation in melanocytes. The invention also relates to the use of dendrobii components and stilbenes for reducing the production of reactive oxygen species and oxidative free radicals. The invention also relates to the use of an extract or component derived from dendrobii or stilbenes for formulating a product for skin protection, skin whitening and/or anti-skin ageing. The invention also provides compounds for the preparation of compositions for the treatment, prevention and/or delay of progression of skin darkening or for skin lightening and skin protection, which compounds are synthesized from dihydro-resveratrol. The invention also provides a related synthesis method.
PURPOSE: Breast cancer survivors (BCS) suffer severe vulvo-vaginal atrophy (VVA) and some of the most effective therapies are contraindicated. In literature we have no data about the non-ablative CO2 laser on these women. The aim of this study was to examine its efficacy, safety and acceptability in BCS.
MATERIALS AND METHODS: The enrolled women underwent 3 sessions of laser therapy (t0, t1, t2) and a one-month follow up examination (t3). At each time point we measured objective signs of VVA via VHI (Vaginal Health Index) and VuHI (Vulvar Health Index) and subjective parameters (Dryness, Burning, Itching, Dysuria) via visual analog scales (VAS). In sexually active women we evaluated the sexual function with FSFI (Female Sexual Function Index), FSDS (Female Sexual Distress Score) scores and MENQOL (menopause quality of life questionnaire).
RESULTS: We enrolled 26 BCS. The mean VHI, VuVHI, dryness and burning VAS scores improved significantly and this improvement was not influenced by the initial VVA grade. MENQOL sexual domain, Lubrication, Orgasm and Pain domains and FSFI total score improved significantly, while Desire, Arousal and Satisfaction domains of FSFI and FSDS did not. At t0 women using Aromatase Inhibitors suffered more severe vaginal dryness than women using Tamoxifen or no therapy, but the three subgroups improved without differences. No adverse event and minimum discomfort were reported.
CONCLUSIONS: The non-ablative CO2 laser is a safe and effective treatment of VVA and has positive effects on sexual function in BCS regardless the use of adjuvant therapies and the initial grade of VVA.
ABSTRACT         This invention relates to benzoporphyrin containing vesicles which are suitable for pharmaceutical application.,  In particular, the present invention relates to a liposomal prepara-tion of benzoporphyrin (BPD) incorporated into vesicles compris-ing a liposome forming lipid such as EPC or DMPC at a drug to lipid ratio of greater than 100 ug/umole lipid which will allow adequate drug dosing with relatively low lipid concentration.  In an additional aspect of the present invention, sized liposomes are described which are storage stable.  Certain sized BPD-containing vesicles (no greater than about 120 nm in diameter) permit sterilization by terminal filtration.  Further, a lyophil-ized preparation of the BPD lipid mixture can be obtained from aqueous buffer under conditions which do not result in vesicle fusion/aggregation or BPD precipitation.         Liposomes according to the present invention are able to accommodate surprisingly large amounts of BPD within the bilayer of the liposome, rather than in the encapsulated buffer.  The advantages of this surprising aspect of the present invention includes the ease of manufacture and the cost savings associated with an efficient use of BPD are also presented.
FIELD: agriculture.SUBSTANCE: invention refers to agriculture, namely to veterinary gynecology. Disclosed is a preparation for preventing and treating endometritis in cows in the form of a plant extract of raw material from birch wood processing wastes in a water-dispersed state, with the following ratio of components: raw material from birch wood processing wastes – 18–22 wt%, water – balance. Raw material contains birch bark and bast lubes at the following ratio: birch bark – 17–23 wt%, birch bast – 77–83 wt%. Also disclosed is a method for preparing a preparation for preventing and treating endometritis in cows by extraction, including grinding raw materials, pouring with distilled water and treatment with frequency vibrations. Grinding is performed to 1–2 mm fraction, vibration treatment is carried out using oscillations in infrasound frequency range. Duration of vibration treatment is 15–16 days to obtain water-dispersed with particle size of 15–27 mcm vegetal extract of raw material from wastes of birch wood processing. Then, the extract is packaged in sterile conditions.EFFECT: invention enables to obtain an effective herbal preparation for treating cows' endometritis.3 cl, 6 tbl, 6 dwg
PAC-Man represents an integrated DSD model for mothers and infants that brings the following three evidence-based practices into the community for EMTCT: 1) pediatric active case finding using novel POC EID technology; 2) same-day ART initiation for infants newly diagnosed with HIV infection; and 3) mVL testing and back-to-care services. PAC-Man uses a mobile approach to offer EMTCT services in the community and reach "high risk" MIPs. Delivering the PAC-Man model will be done under the auspices of routine care, applying an overarching implementation strategy of creating new mobile care teams equipped with new diagnostic technology who deploy the m-PIMA in community settings.