anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in pregnancy are associated with the development of preeclampsia and fetal growth restriction (FGR). Recently, preeclampsia was linked to impaired maternal hemodynamic function. This retrospective study evaluated singleton pregnancies with COVID-19 during pregnancy and healthy pregnant controls matched for gestational age from November 2020 to March 2022. Non-invasive assessment of maternal hemodynamics by continuous wave Doppler ultrasound measurements (USCOM-1A® Monitor) and oscillometric arterial stiffness (Arteriograph) was performed. Overall, 69 pregnant women were included-23 women after COVID-19 during pregnancy and 46 healthy controls. While two women (8.7%) were admitted to the hospital due to COVID-19-related symptoms, none required intensive care unit admission or non-invasive/invasive ventilation. There were no statistically significant differences in the majority of hemodynamic parameters between the two cohorts. The prevalence of FGR was significantly higher in the COVID-19 during pregnancy group (9.5% vs. healthy controls: 0.0%; p = 0.036), especially in nulliparous women. No difference in angiogenic markers and neonatal outcomes were observed between pregnant women after COVID-19 and healthy controls. In conclusion, no significant differences in hemodynamic parameters or neonatal outcome were observed in women with COVID-19 during pregnancy. However, an increased prevalence of FGR could be described.
It was emphasized that the participants should jump from the 30 cm high box and immediately after landing, jump as high and forward as possible and maintain the final landing stance for 5 seconds. Participants were asked to perform 5 drop vertical jumps and the jumps performed were evaluated. After pretest evaluations were recorded, verbal training group participants performed two training blocks, receiving instructions specific to their group. Participants were given a combined verbal instruction such as "Focus on how hard you push yourself off the ground after the jump and how quickly you straighten your knees during this push", in which internal and external focus directions were given simultaneously. After receiving the instructions, the participants performed 2 drop vertical jumps, 10 times each.
OBJECTIVE: To review the advancement made in the understanding of valgus impacted proximal humeral fracture (PHF).
METHODS: The domestic and foreign literature about the valgus impacted PHF was extensively reviewed and the definition, classification, pathological features, and treatment of valgus impacted PHFs were summarized.
RESULTS: PHF with a neck shaft angle ≥160° is recognized as a valgus impacted PHF characterized by the preservation of the medial epiphyseal region of the humeral head, which contributes to maintenance of the medial periosteum's integrity after fracture and reduces the occurrence of avascular necrosis. Therefore, the valgus impacted PHF has a better prognosis when compared to other complex PHFs. The Neer classification designates it as a three- or four-part fracture, while the AO/Association for the Study of Internal Fixation (AO/ASIF) categorizes it as type C (C1.1). In the management of the valgus impacted PHF, the selection between conservative and surgical approaches is contingent upon the patient's age and the extent of fracture displacement. While conservative treatment offers the advantage of being non-invasive, it is accompanied by limitations such as the inability to achieve anatomical reduction and the potential for multiple complications. Surgical treatment includes open reduction combined with steel wire or locking plate and/or non-absorbable suture, transosseous suture technology, and shoulder replacement. Surgeons must adopt personalized treatment strategies for each patient with a valgus impacted PHF. Minimally invasive surgery helps to preserve blood supply to the humeral head, mitigate the likelihood of avascular necrosis, and reduce postoperative complications of bone and soft tissue. For elderly patients with severe comminuted and displaced fractures, osteoporosis, and unsuitable internal fixation, shoulder joint replacement is the best treatment option.
CONCLUSION: Currently, there has been some advancement in the classification, vascular supply, and management of valgus impacted PHF. Nevertheless, further research is imperative to assess the clinical safety, biomechanical stability, and indication of minimally invasive technology.
It is an interventional study in which 60 stroke patients estimated to enroll according to random allocation and will divided into two groups. The study group participants will involve in Telerehabilitation sessions will be based on low-impact rhythmic movements, guided by video, according to the protocol of (Schachter et al., 2003). The telerehabilitation program will be moderately intense aerobic exercise 3 times per week and will be included 3 parts: warm-up, central part, and cool-down. Each session : 30 min, 3 sessions/ week for 3 months.

The repetition rate will determine the intensity of the exercises: 10, 15, 20, or 25 repetitions per minute. The exercise intensity of each telerehabilitation session will be individually adjusted by the participants' Modified Borg perceived exertion. With the Baduanjin exercise program is delivered individually, at each patient's home, through telerehabilitation, with direct remote supervision by a physiotherapist. Each session consists of a short preparatory phase (stretching exercises and abdominal breathing patterns) follows by a set of seven movements, adapts from the eight-section brocade Baduanjin exercise that originally comprises eight movements, repeated a certain number of times.The control group will receive the same aerobic exercises only
The invention relates to a synthesizing method of a heat-sensitive POSS-containing inorganic/high-molecular hybrid. The invention belongs to the technical field of novel materials. According to the invention, first, gamma-mercaptopropyltrimethoxysilane is adopted as a raw material; with a hydrolysis-condensation reaction of the raw material, monothiol-functionalized polyhedral silsesquioxane (POSS-SH) is synthesized; N-isopropylacrylamide (NIPAM) is adopted as a monomer, and is subject to free-radical polymerization under the existence of POSS-SH; the reaction is stopped under a telomerization effect of hydrosulfide groups, and an obtained product is the POSS-containing inorganic/high-molecular hybrid with a star-like structure. When the weight ratio of POSS-SH to NIPAM is changed among 1:80, 1:160, 1:240, and 1:320, the number average molar weight of the POSS-containing inorganic/high-molecular hybrid is respectively 4260, 7690, 9890, and 13650. The polymer can form nano-grade micelles in a water solution. Relative to the amount of NIPAM, when 1% N,N-methylene bisacrylamide is added to the system to be subject to polymerization, hybrid hydrogel is obtained. The hybrid hydrogel has enhanced mechanical strength, higher swelling speed and higher de-swelling speed than pure PNIPAM
Patients receive thalidomide as in arm I and fludarabine IV over 30 minutes on days 1-5. Treatment with fludarabine repeats every 28 days for 6 courses. Once fludarabine is completed, patients continue to receive thalidomide alone as in arm I.
PROBLEM TO BE SOLVED: To obtain a new sesquiterpene compound which is a physiologically active ingredient contained in a mushroom, has a strong antifungal force against fungi causing opportunistic visceral mycosis and is useful as an active ingredient for bactericides and fungicides. SOLUTION: This sesquiterpene compound is represented by formula I (R is H, a lower alkyl), e.g. a compound of formula II. The compound of formula II has the following physicochemical properties. The nature: colorless columnar crystal; mol.wt.: 394; molecular formula: C22 H34 O6 ; coloring reactions: positive to Ehrlich reagent (reddish violet color), positive to anisaldehyde reagent (bluish violet color), positive to 50% sulfuric acid reagent (blown color), etc. The compound of formula I is obtained by extracting the fruit body of Roseofomes subflexibilis (Berk. et Curt.) Aoshi, a mushroom belonging to the family Myriangiaceae, with a lower alcohol, ethyl acetate, acetone, etc., and subsequently isolating the compound of formula I from the extract.
This study aimed to preliminarily investigate the associations between performance on the integrated Digit-in-Noise Test (iDIN) and performance on measures of general cognition and working memory (WM). The study recruited 81 older adult hearing aid users between 60 and 95 years of age with bilateral moderate to severe hearing loss. The Chinese version of the Montreal Cognitive Assessment Basic (MoCA-BC) was used to screen older adults for mild cognitive impairment. Speech reception thresholds (SRTs) were measured using 2- to 5-digit sequences of the Mandarin iDIN. The differences in SRT between five-digit and two-digit sequences (SRT5-2), and between five-digit and three-digit sequences (SRT5-3), were used as indicators of memory performance. The results were compared to those from the Digit Span Test and Corsi Blocks Tapping Test, which evaluate WM and attention capacity. SRT5-2 and SRT5-3 demonstrated significant correlations with the three cognitive function tests (rs ranging from -.705 to -.528). Furthermore, SRT5-2 and SRT5-3 were significantly higher in participants who failed the MoCA-BC screening compared to those who passed. The findings show associations between performance on the iDIN and performance on memory tests. However, further validation and exploration are needed to fully establish its effectiveness and efficacy.
Control group received regular hemodialysis treatment, no given Ear pills and Shengmai capsule completed in the treatment of the first stage. After 4 weeks after a washout period, two groups of cross accept the next phase of treatment.
PURPOSE:A skin cosmetic having improved safety, stability, cleaning properties, etc., without damaging characteristic purposes of colorant, obtained by blending a skin cosmetic with colorant microcapsule comprising shellac as a wall membrane material obtained by spray drying granulator. CONSTITUTION:A skin cosmetic containing microcapsules which are made into microcapsules by the use of a spray drying granulator having the simplest operation, comprise shellac as a wall membrane material and a colorant (organic inorganic pigment or dyestuff such as tar dyestuff, natural dyestuff, etc.) as a core substance and have 5-20 micron average particle diameter. Since the microcapsules have no aggregation between the particles and provide good dispersion into water and oil agent, a used cosmetic is extremely readily washed away. Since the colorant has improved light resistance and heat resistance, materials which could not used with respect to stability can be added to cosmetic. Since the membrane is further transparent and lustrous, the cosmetic has merits of further clearer color, etc.
The invention provides series amiopyrimidine-modified gold nano particles. In the amiopyrimidine-modified gold nano particles, the amiopyrimidine may be one or more of 2-thiol-4,6-diamino-pyrimidine, 2-thiol-4-amino-pyrimidine and 2,4-diamino-6-mercaptopyrimidine. The particle size of the amiopyrimidine-modified gold nano particles is 1.5 to 10.0 nanometers; and the molar content ratio of amiopyrimidine molecules to gold element in the nano particles ranges from 0.1 to 0.9. The amiopyrimidine-modified gold nano particles have antibacterial effect, can be widely used for preparing antibacterial medicines such as anti-gram-negative bacilli penicillins medicines, anti-gram-positive bacterium medicines or/and anti-multi-medicine-resistance clinically isolated bacterium medicines. The invention also provides the preparation method and use of the amiopyrimidine-modified gold nano particles. The invention further provides antibacterial medicines containing the amiopyrimidine-modified gold nano particles.
BACKGROUND: Education during pregnancy is important for the development of the pregnant woman's ability to adapt to change and for a healthy birth. In this study, we aimed to examine the effects of education through a diabetes education program on maternal and newborn health in women diagnosed with gestational diabetes.
MATERIALS AND METHODS: In our study, we compared the maternal and neonatal health outcomes of pregnant women who participated in the diabetes education program and were diagnosed with gestational diabetes with the outcomes of pregnant women who did not participate in the diabetes education program and were diagnosed with gestational diabetes. The study included patients who were diagnosed with diabetes between 24and 26 weeks gestation at a tertiary education and research hospital and who underwent a 75-gram OGTT test. Age, BMI, parity, method of delivery, weight gain during pregnancy, newborn birth weight, gestational age and Apgar scores were compared.
RESULTS: The study included 119 patients and analyzed maternal-neonatal outcomes. There were no statistically significant differences in age (33 ± 5.7 versus 31 ± 5.2), body mass index (BMI) (32.2 vs. 31.2), gravidity, parity, number of miscarriages, mode of delivery, family history of diabetes, smoking, prenatal corticosteroid use, and gestational age at delivery. The HbA1c value (p: 0.013), the total weight gain during pregnancy (p: 0.015), the need for insulin treatment (p: 0.002), and the birth weight (0.005) were significantly higher in the group without diabetes education.
CONCLUSION: In our study, diabetic school education was associated with lower HbA1c levels, less weight gain and less need for insulin therapy. When the results were categorized by insulin use, it was found that in patients using insulin, those who received diabetic school education had fewer macrosomic fetuses, whereas in patients not using insulin, those who received diabetic school education had lower maternal weight gain during pregnancy.
BACKGROUND: Patients' level of medication adherence provides conflicting results in its relationship to patient activation. Multiple factors may be contributing to these mixed results.
OBJECTIVES: The primary purpose was to assess the association of patient activation to medication adherence in adults with chronic health conditions and low health literacy (HL). Secondary objectives were to determine whether age, education, gender, and race were associated with activation.
METHODS: Participants completed self-report questionnaires regarding chronic disease self-management. Patient activation was measured using Hibbard's Patient Activation Measure (PAM). Self-report of medication adherence was determined using the Gonzalez-Lu adherence questionnaire. Block regressions first assessed the relation of demographic variables and education to adherence and then the added relation of patient activation in a second model.
RESULTS: The analyses included 301 participants (mean age 58 years; 53% female; mean chronic conditions of 6.6). Some of the most common chronic conditions included hypertension (60%), arthritis (51%), depression (49%), and hyperlipidemia (43%). The relation of older age to greater medication adherence was significant (P < 0.05) in both models. The addition of PAM was significantly related to better adherence (P < 0.001) and also increased the R squared value from 0.04 to 0.09. This change resulted in a moderate effect size (d = 0.50).
CONCLUSION: Evaluating patient activation at baseline may predict those more likely to be medication adherent in patients with low HL.
ALX-0061 150 mg every 4 weeks from baseline through Week 12 + placebo every 2 weeks from baseline through Week 12. The last injection with study drug was administered at the Week 10 visit.
Patient will be put nasoprong oxygen 2L/min throughout surgery. Oxygen therapy will be discontinued once surgery ends. FiO2 will be titrated by 0.1 increment to a SpO2 of ≥94%.
The study consists of a single treatment group, which will receive the first-line therapy for the disease. The therapy is the standard radiotherapy and a dose of the investigational product (nimotuzumab) at 150 mg/m2.
The present invention provides a tobacco-free cigarette. Tobacco is used as the main material in tobacco cigarettes produced through flavoring and refining. Smokers consider that smoking can allay tiredness, enhance the vigor and improve work efficiency, so many smokers have great dependence on cigarettes. However, nicotine contained in cigarettes is a toxic substance harmful to human bodies. The cigarette of the present invention utilizes non-toxic and edible leaves of plants which contain alkaloid but no nicotine as raw materials for producing cigarettes, wherein the leaves mainly comprise lotus leaves, mulberry leaves, tomato leaves, corn leaves, eggplant leaves, bamboo leaves, etc. The cigarette also has the unique flavor of tobacco cigarettes. Thus, not only the habitual psychological dependence of smokers on cigarettes can be satisfied, but also the harm to human health can be reduced.
Tablets for oral administration under fed conditions. Zamicastat has to be taken in the morning after breakfast. Each patient will continue treatment with the individual highest tolerated dose (HTD) he/she was taking at MPV3 of the study BIA-51058-201 and will take this dose until visit V5.
BACKGROUND: Complications of atrial fibrillation (AF) include ischemic events originating within the left atrial appendage (LAA), a protrusion of the left atrium with variable morphological characteristics. The role of the patient specific morphology and pathological haemodynamics on the risk of ischemia remains unclear.
METHODS: This work performs a comparative assessment of the hemodynamic parameters among patient-specific LAA morphologies through fluid-structure interaction computational analyses. Three LAA models per each of the four commons patient-specific morphological families (chicken wing, cactus, windsock, and cauliflower) were analysed. Mechanical properties of the tissue were based on experimental uniaxial tests on a young pig's heart. Boundary conditions were imposed based on clinical assessments of filling and emptying volumes. Sinus rhythm and atrial fibrillation operative conditions were simulated and analysed.
RESULTS: For each model, the effect of morphological and functional parameters, such as the number of trabeculae and LAA stroke volume, over the hemodynamics established into the appendage was analysed. Comparison between results obtained in healthy and diseased conditions suggested the introduction of a new parameter to quantify the risk of thrombosis, here called blood stasis factor (BSF). This is defined as the LAA surface area which permanently experiences levels of shear strain rate inferior to a threshold value, set to 5 s-1 (BSF5).
CONCLUSIONS: This work suggests that the current morphological classification is unsuitable to evaluate the probability of thrombus formation. However, hemodynamic parameters easy to determine from clinical examinations, such as normalised stroke volume, LAA orifice flow rate and presence of extensive trabeculations can identify departures from healthy hemodynamics in AF and support a more systematic stratification of the thromboembolic risk.
FIELD: medicine. SUBSTANCE: invention relates to medicinal agents of natural origin. The proposed agent is a mixture of 45% spirituous tinctures taken at an equal ratio of bioactive components of plant and animal origin. An agent shows a general tonic effect and provides good therapeutic results in patients with cardiovascular diseases, tuberculosis and in gerontology. An agent enhances tonus and working capacity for a short treatment course. EFFECT: enhanced effectiveness of an agent. 5 cl
Aminoleban EN™ was administered at a dose of 100 g per day commencing two weeks prior to surgery. A 100 g dose of Aminoleban EN™ contains 13.0 g of free amino acids, 13.0 g of gelatin hydrolysate, 1.0 g of casein, 62.1 g of carbohydrate, 7.0 g of lipid, glycyrrhizin, and other components, producing 420 kcal. The AEN group included 40 patients who were administered 100 g of Aminoleban EN™ as 50 g during the day and 50 g as a late evening snack.
The invention relates to an assembly consisting of at least two medical treatment units (1, 1'), each of which can be allocated to a patient and at least two peripheral devices (5, 5'), each of which can be allocated to a patient. The peripheral devices and the treatment units have means (7, 10, 14, 16) for allocating a peripheral device to a treatment unit and means (16) for verifying the allocation of a peripheral device to a patient. To allocate a peripheral device to a treatment unit, the peripheral device is placed by operators in a receiving unit (14) belonging to the treatment unit. Said receiving unit is preferably designed as a charging station for the battery of the peripheral device. In the claimed assembly of treatment units (1) and peripheral devices (5), in the event of a successful allocation of peripheral device and patient, confirmed by the receipt of physiological data of the patient, the operators verify the correct allocation of a peripheral device to the patient and must confirm the correct allocation by confirmation means, for example by pressing a confirmation button (19). The peripheral device is only released if the operator has confirmed the correct allocation, preferably within a predefined time period.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease. Calpain-1 is an effective therapeutic target for vascular endothelial dysfunction and pulmonary hypertension. However, the role of calpain-1 in bleomycin (BLM)-induced IPF has not been defined. The aim of this study was to assess the targeting of calpain-1 by activating ferroptosis in BLM-treated knockout mice and murine lung epithelial-12 cells. The role of calpain-1 in the regulation of IPF was investigated using a BLM-induced IPF mouse model. The results of this study showed that increased expression of calpain-1 was accompanied by increased fibrosis, lipid peroxidation, iron ion accumulation, and Yes-associated protein (YAP) levels and decreased levels of phosphorylated adenosine 5'-monophosphate-activated protein kinase (p-AMPK) in BLM-induced IPF. MDL-28170 (calpain-1 inhibition) treatment and calpain-1 knockdown alleviated ferroptosis and IPF induced by BLM. Overexpression of calpain-1 in murine lung epithelial-12 cells further exacerbated iron accumulation and IPF. Mechanistically, lentivirus-mediated up-regulation of calpain-1 inhibited AMPK activity and promoted the nuclear translocation of YAP, leading to high levels of acyl-CoA synthetase long-chain family 4 and transferrin receptor protein 1 and triggering a ferroptosis response that ultimately exacerbated BLM-induced lung fibrosis. Calpain-1 inhibition reversed these results and ameliorated BLM-induced IPF. In conclusion, these findings suggest that the calpain-1-acyl-CoA synthetase long-chain family 4-transferrin receptor protein 1-ferroptosis-positive regulatory axis contributes to BLM-induced IPF, which indicates that calpain-1 has potential therapeutic value for the treatment of IPF.
A method for repairing defects and reconstructing urothelial structures in vivo has been developed using a fibrous, open synthetic, biodegradable polymeric matrix which is configured to provide the desired corrective structure. The matrix is shaped to correct the defect, then implanted surgically to form a scaffolding for the patient's own cells to grow onto and into. The implantation of the matrix initiates an inflammatory reaction, resulting in urothelial cells, endothelial cells and mesenchymal cells, to migrate into the matrix. The polymer forming the matrix is selected to be biocompatible and degradable in a controlled manner over a period of one to six months, in the preferred embodiment. A preferred material is a poly(lactic acid-glycolic acid) in a fibrous form, such as a woven or non-woven mesh. Examples demonstrate the repair of defects in bladder in rabbits.