anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention provides compounds having the structure: < IMAGE > VI wherein R1 represents alkoxy or aralkoxy, R2 represents hydrogen, alkoxy, aralkoxy, alkyl, aralkyl, or R1 and R2 taken together represent the group -O-CH2-O-, R3 represents hydrogen, alkyl, aralkyl, acyl or a protecting group, Y represents Cl, Br, I or a leaving group and X represents Cl, Br or I. The present invention also provides a process for preparation of compounds VI in a single step wherein X and Y are the same and represent Cl, Br, or I, and R3 is as previously defined except that in this instance, it does not represent a protecting group. According to another aspect of the present invention there are provided compounds VII-a and VII-b having the structure: < IMAGE > wherein R1, R2 and R3 are as previously defined, j is an integer having a value of 0 or 1, Z1 represents a non-reacting electron withdrawing group, and Z2 represents a non-reacting electron withdrawing group or hydrogen, R8 and R9 are the same or different and represent hydrogen, alkyl, aralkyl, alkoxy, or aralkoxy, and R7 represents hydrogen, alkyl, aralkyl or acyl. Compounds VII-a may be prepared from compounds VI through the use of the process of "insertion-cyclization" which is provided by another aspect of the present invention. According to a further aspect of the present invention, compounds VII-a are converted into tetralone III-a shown below: < IMAGE > III-a wherein R1, R2, R3, Z1, Z2, R7, R8 and R9 are as previously defined. Certain of these compounds can, in turn, be readily converted into picropodophyllin and picrosikkimotoxin. The latter can be converted into known antineoplastic agents by known procedures.
PURPOSE: Provided is a composition comprising, as an active ingredient, sauchinone for treatment and prophylaxis of inflammatory diseases. It has anti-inflammatory effect by inhibiting inducible expression of cyclooxygenase-2(COX-2). CONSTITUTION: A composition for treatment and prophylaxis of inflammatory diseases is characterized by comprising, as an active ingredient, sauchinone represented by the formula(I). The inflammatory diseases include articular rheumatism or asthma. The sauchinone is isolated and purified from the Saururs chinesis(Lour.) extract.
The purpose of this study is to determine the areas of the brain responsible for tics in patients with Tourette's syndrome and chronic motor tic disorder using \[15O\]H2O. Previous neuroimaging studies have looked at brain activity during tics using functional magnetic resonance imaging (fMRI), and positron emission tomography (PET), but a major drawback of these studies lay in the difficulty distinguishing between the activity in the brain responsible for tic generation versus activity in motor-related structures due to tic movements. We plan to overcome this difficulty in our paradigm using two rest conditions without any movement. One is a state when patients suppress their tics and the second is sleep state, when tics usually cease or are at least very infrequent. 23 adult patients with a DSM-IV-TR (American Psychiatric Association 2000) diagnosis of a tic disorder and frequent tics will be studied. These two rest states will be compared with a condition where tics are allowed to occur spontaneously. The differential activation of brain areas between these three conditions should help to elucidate/define the regions of the brain responsible for generation of tics.
Rivaroxaban group for 1 month : initial 5 days after randomization rivaroxaban 10mg QD will be administered. Rivaroxaban 20mg QD, but 15mg in case of Cr CL will be administered for remaining 25 days.
Women randomized to receive three 800 mcg doses of misoprostol taken buccally in three hour intervals. All women receive a semi-quantitative pregnancy test for at-home follow up.
Systems and methods for respiratory health management are provided. An air filtration and analysis system may comprise an apparatus configured to be worn by a user. The apparatus may comprise a filtration device. The system may also include a plurality of sensors configured to collect data. A portion of the sensor data may be indicative of (i) one or more characteristics of the air inhaled and/or exhaled by the user, and/or (ii) an environment in which the user is located. At least one sensor and/or the apparatus may be in communication with a processor that is configured to analyze the collected sensor data.
The inhibition of soluble epoxide hydrolase (sEH) can reduce the level of dihydroxyeicosatrienoic acids (DHETs) effectively maintaining endogenous epoxyeicosatrienoic acids (EETs) levels, resulting in the amelioration of inflammation and pain. Consequently, the development of sEH inhibitors has been a prominent research area for over two decades. In the present study, we synthesized and evaluated sulfonyl urea derivatives for their potential to inhibit sEH. These compounds underwent extensive in vitro investigation, revealing their potency against human and mouse sEH, with 4f showing the most promising sEH inhibitory potential. When subjected to lipopolysaccharide (LPS)-induced acute lung injury (ALI) in studies in mice, compound 4f manifested promising anti-inflammatory efficacy. We investigated the analgesic efficacy of sEH inhibitor 4f in a murine pain model of tail-flick reflex. These results validate the role of sEH inhibition in inflammatory diseases and pave the way for the rational design and optimization of sEH inhibitors based on a sulfonyl urea template.
<P>PROBLEM TO BE SOLVED: To provide a makeup cosmetic smoothly slipping, spreading and forming a uniform cosmetic film on skin during use and affording a bright finish with transparency.  <P>SOLUTION: The makeup cosmetic is obtained by formulating the following ingredients (A) and (B). (A) composite powder which is prepared by laminating and coating a flaky substrate with at least two layers of coloring layers having ≥2 refractive index and has a light scattering layer having 1.3-1.8 refractive index between the coloring layers or in the outermost layer and (B) flaky platy powder having ≥30 aspect ratio. The coloring layers in the composite powder of the ingredient (A) are two or more kinds selected from titanium oxide, iron oxide and zinc oxide. The makeup cosmetic comprises the light scattering layer in the composite powder of the ingredient (A) which is one or more kinds selected from silicic acid anhydride and aluminum oxide.  <P>COPYRIGHT: (C)2007,JPO&INPIT
AVINZA was studied in over 140 healthy volunteers and 560 patients with chronic, moderate to severe pain who participated in 6 pharmacokinetic studies, 4 clinical studies and 3 studies which provided both pharmacokinetic and clinical data. The patient population included those who were either receiving chronic opioid therapy or had a prior sub-optimal response to acetaminophen and/or NSAID therapy, as well as patients who previously received intermittent opioid analgesic therapy. In the controlled clinical studies, patients were followed from 7 days to up to 4 weeks, and in the open label studies, patients were followed for up to 6 to 12 months. 

AVINZA was studied in a double-blind, placebo-controlled, fixed-dose, parallel group trial in 295 patients with moderate to severe pain due to osteoarthritis. These patients had either a prior sub-optimal response to acetaminophen, NSAID therapy, or previously received intermittent opioid analgesic therapy. Thirty-milligrams AVINZA capsules administered once-daily, either in the morning or the evening, were more effective than placebo in reducing pain.

This study was not designed to assess the effects of AVINZA on the course of the osteoarthritis.
Apparatus and associated methods relate to receiving a patient health record, determining a relationship between the health record and the patient health history, determining a condition associated with the health record and the location on the patient's body affected by the condition, and automatically presenting the relationship between the health record and health history based on the condition. In an illustrative example, the patient health record may be a doctor's diagnosis. The relationship between the health record and the patient health history may link multiple health records medically related to the received health record. In some examples, the relationship between the health record and health history may be comorbidity. The health history may include conditions complicating the condition associated with the health record. Various examples may advantageously present the patient's health status and conditions interactively visualized as a function of the patient's body, and the medical condition type or severity.
Elderly in this group will continue to attend community activity as usual. The activity includes active activity is 60 minutes and frequency is 2 times/week.
A device and a system, based upon Deep Optical Scanning (DEOS), for the detection of certain cancers such as breast cancer and the determination of their response to therapy. DEOS is based upon the nonlinear optical interaction of incident laser generated light with tissue. The cancers may either be subsurface or on the surface. The system includes hardware and software components that form subsystems including: an Optical Electronic Subsystem, a Digitization Subsystem, a Parameter Computation Subsystem, an Archive, an Artificial Intelligence Subsystem, and a Presentation Subsystem. The device can be made portable and is non-invasive in its application to a patient. The system can be integrated into a hybrid architecture with other imaging techniques used for the detection of cancers.
Frailty is an important predictor of mortality, health care costs and utilization, and health outcomes. Validated measures of frailty are not consistently collected during clinical encounters, making comparisons across populations challenging. However, several claims-based algorithms have been developed to predict frailty and related concepts. This study compares performance of three such algorithms among Medicare beneficiaries. Claims data from 12-month continuous enrollment periods were selected during 2014-2016. Frailty scores, calculated using previously developed algorithms from Faurot, Kim, and RAND, were added to baseline regression models to predict claims-based outcomes measured in the following year. Root mean square error and area under the receiver operating characteristic curve were calculated for each model and outcome combination and tested in subpopulations of interest. Overall, Kim models performed best across most outcomes, metrics, and subpopulations. Kim frailty scores may be used by health systems and researchers for risk adjustment or targeting interventions.
<P>PROBLEM TO BE SOLVED: To provide a cell differentiation retarder obtained by culturing a stem cell or a embryonic stem cell in a undifferentiated state without using a feeder cell and to provide a culturing method using the cell differentiation retarder and to provide a culture solution by using the culturing method and a cell cultured and prepared by using the cell differentiation retarder.  <P>SOLUTION: Enhancing effect of undifferentiated and pluripotent embryonic stem cell is found in a low molecular compound, particularly indole derivative. The stem cell differentiation retarder comprises the low molecular compound, particularly the indole derivative as an active ingredient. The method for culturing the embryonic stem cell comprises culturing the embryonic stem cell in large amount in safe and undifferentiated state in the absence of the feeder cell by using the indole derivative. The culture solution of the stem cell comprises the indole derivative. The cell is cultured and prepared by using the indole derivative as the cell differentiation retarder.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Neoadjuvant chemotherapy (NAC) improves overall survival in muscle-invasive bladder cancer (MIBC). Older patients often do not receive NAC due to its potential toxicities. We examined treatment patterns of elderly MIBC patients as well as impact of NAC on survival in this population. The National Cancer Database was queried from 2006 to 2019 for stage T2-T4a MIBC patients ≥ 80 years old. Treatment exposures (extirpative surgery; chemotherapy; radiation) were ascertained. Kaplan-Meier survival curves were generated based on treatment modalities (no treatment; radiation only; chemotherapy only; chemoradiation; surgery only; NAC with surgery). Multivariable Cox proportional hazards regression assessed associations with overall survival (OS). The cohort included 16,391 patients (mean age 86 years); 51% received treatment. MIBC treatment was less common with advancing age; patients receiving NAC then surgery were younger and had lower comorbidity scores. From 2006 to 2019, more patients received chemoradiation, while rates of NAC rose modestly. Median OS for the NAC with surgery group was 48 months versus 9 months for the no treatment group. Log-rank tests showed significantly improved survival in the NAC with surgery group compared to the surgery only group, while Cox proportional hazards regression analysis showed highest survival benefit in the NAC with surgery group. Only half of elderly MIBC patients received treatment, with fewer undergoing curative intent. NAC with surgery was associated with the greatest survival benefit. While our findings should be taken in the context of potential selection bias and patient preferences, they support NAC as part of shared-decision making regardless of age.
ELIGARD is an injectable suspension of leuprolide acetate available in a pre-connected syringe system and packaged with a sterile safety needle and cap (Table 2), a desiccant, prescribing information and instructions for use. The pre-connected syringe system consists of syringe A and syringe B connected using a coupling device. Syringe A contains the in situ polymeric extended release technology and the syringe B contains leuprolide acetate powder. When reconstituted, ELIGARD is administered as a single dose. Refer to Table 10 for details of the description of the dosage form before and after mixing [see How Supplied/Storage and Handling (16)].

Table 2. Specifications for ELIGARD Sterile Safety Needle and Cap
The present invention relates to a medicine composition for treating traumatic injuries, which is a curative plaster prepared from natural Chinese herbal medicines as raw materials and is prepared by refining with an integrated method of a conventional technology and a traditional method. The present invention is characterized in that the curative plaster is prepared from raw material components of parts by weight: 10 to 50 of sappanwood, 10 to 50 of safflower, 10 to 30 of pangolin scale, 10 to 30 of olibanum, 10 to 30 of myrrh, 10 to 30 of dragon blood, 10 to 30 of panax notoginseng, 10 to 30 of cambogia, 10 to 30 of honeycomb and 10 to 30 of snake slough. Curative powdered medicine for oral administration can also be prepared from the partial raw materials by the present invention. Because normal blood which is in the blood vessels can not suffer from damage, and static blood which is outside the blood vessels fails to stay in the blood vessels, the present invention has no damage to human blood. Treatment by using the medicine composition of the present invention has no requirements of bloodletting by pricking with a needle and no requirements of static blood expelling by cutting with a knife. Patients only need to use an external application medicine of a curative plaster or use the curative plaster with an oral administration medicine of a curative powdered medicine, and static blood existing inside the bodies can be magically suspended out of the bodies; thus, the medicine composition is beneficial to clearing away static blood and radically curing injuries and has no recurrence. The medicine composition of the present invention, which can be used with other curative medicines for treatment with obvious therapeutic effects, has most obvious effects and good therapeutic effects on old injuries and recurrence pain of more than thirty years; more than 90% patients can be radically cured.
The intervention-arm will have a pelvic exam performed with vaginal swab collection at their initial obstetric visit (standard of care). The women undergoing the intervention will then subsequently undergo additional vaginal swab collections in 2 week intervals starting at 16 weeks gestational age until 34 weeks gestational age. Subjects will be informed of the results of the vaginal swab. If positive for an infection, subjects will be provided with the appropriate treatment in pregnancy.
BACKGROUND: Acid sphingomyelinase deficiency (ASMD) is an autosomal recessive lysosomal storage disease (LSD) associated with biallelic pathogenic variants in the sphingomyelin phosphodiesterase 1 (SMPD1) gene.
OBJECTIVES: The aim of this study was to provide the 2024 update on chronic visceral and neurovisceral ASMD diagnosed in the infancy/childhood in Polish patients.
MATERIAL AND METHODS: All the patients diagnosed in the pediatric age (0-18 years) with ASMD, both chronic neurovisceral and visceral type, and then systematically followed up, were enrolled into the study.
RESULTS: A total number of 7 patients were enrolled into the study. Four patients were previously reported. Two patients were newly recognized with ASMD - 1 with chronic visceral and 1 with chronic neurovisceral ASMD. Splenomegaly was noted in all the patients while a mild liver enlargement was observed in 4 of 7 patients. All patients presented with decreased high-density lipoprotein cholesterol (HDL-C) and decreased serum 25-hydroxy-vitamin D concentration while almost all (6 of 7) with hypercholesterolemia. Cherry-red spot was observed in 5 of 7 patients, including 1 patient with neurovisceral type. Seven various SMPD1 gene variants were identified and missense variants were the most common types of genetic lesions, comprising 71% of all alleles. In all the screened patients, lyso-sphingomyelin (lyso-SM) in dried blood spot (DBS) was found elevated; however, the greater values were observed for patients with chronic neurovisceral type.
CONCLUSION: Chronic acid sphingomyelinase deficiency (ASMD) is a slowly progressive disease. Pediatric ASMD is characterized by spleno-hepatomegaly, dyslipidemia (with decreased HDL-C as the most characteristic) and infiltrative (interstitial) lung disease. Both visceral and neurovisceral chronic ASMD patients could present with cherry-red spot. Both acid spingomyelinase activity and lyso-spingomyelin concentration in DBS should be regarded as a first-tier screening method into ASMD.
In our extended studies, we have directly examined the expressions of various inhibitory natural killer cell Receptors (iNKRs) on Tumor-infiltrating lymphocytes (TILs) derived from human Cervical cancer (CC) by triple-color flow cytometry with combination of different surface markers. We found up-regulated expression of certain iNKRs (CD94/NKG2A) in TILs and in mixed lymphocyte-cancer cell cocultures. In our previous studies, we demonstrated that certain cytokines, including IL-10, TGF-beta (Sheu et al, Journal of Immunology, 2001, 167:2972-2978), and IL-15 (Sheu et al, Cancer Research, 2005, 65:2921-2929) can be expressed by CC cells. We further demonstrated that activated T cells bear iNKRs which inhibit cytotoxic activity. iNKRs are proposed to restrain the T cell receptor (TCR)-mediated cytolysis. We found that CC cells had altered HLA-A, -B, and -C molecules in a cancer microenvironment. The acquisition of both NK-like activity and expression of iNKRs by these T cells is parallel to prevent damage to normal host cells. However, there is also limited knowledge about the regulatory role of iNKR expression in T cell cytotoxicity.
<P>PROBLEM TO BE SOLVED: To provide a carbon dioxide composition for external use obtaining strong cosmetic and medical effects by solely applying thinly a little amount for a short period of time.  <P>SOLUTION: The carbon dioxide composition for external use in which carbon dioxide is dissolved in a non-bubble state in a viscous material comprising at least water and a thickener is provided. The composition can be simply mass-produced by using an impermeable sealable mixer. Another method for producing the carbon dioxide composition for external use is to produce carbon dioxide by fermentation bacteria in a sealable container, thereby not only production of the carbon dioxide composition for external use and filing to the sealable container are carried out only once, but secondary metabolites additively or synergistically acting to the cosmetic and medical effects of carbon dioxide are generated by the bacterial strain and the carbon dioxide composition for external use having higher additional values is obtained. Another carbon dioxide composition for external use includes at least the fermentation bacteria, metabolites of the same, a thickener, water and carbon dioxide. The strong cosmetic and medical effects can be simply obtained by using a little amount of the carbon dioxide composition for external use.  <P>COPYRIGHT: (C)2010,JPO&INPIT
The coacervation of alpha-synuclein (αSyn) into cytotoxic oligomers and amyloid fibrils are considered pathological hallmarks of Parkinson's disease. While aggregation is central to amyloid diseases, liquid-liquid phase separation (LLPS) and its interplay with aggregation have gained increasing interest. Previous work shows that factors promoting or inhibiting aggregation have similar effects on LLPS. This study provides a detailed scanning of a wide range of parameters, including protein, salt and crowding concentrations at multiple pH values, revealing different salt dependencies of aggregation and LLPS. The influence of salt on aggregation under crowding conditions follows a non-monotonic pattern, showing increased effects at medium salt concentrations. This behavior can be elucidated through a combination of electrostatic screening and salting-out effects on the intramolecular interactions between the N-terminal and C-terminal regions of αSyn. By contrast, this study finds a monotonic salt dependence of LLPS due to intermolecular interactions. Furthermore, it observes time evolution of the two distinct assembly states, with macroscopic fibrillar-like bundles initially forming at medium salt concentration but subsequently converting into droplets after prolonged incubation. The droplet state is therefore capable of inhibiting aggregation or even dissolving aggregates through heterotypic interactions, thus preventing αSyn from its dynamically arrested state.