anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The purpose of this study is to determine how daily activities, home, neighborhood and school environments affect Arkansas children's health. Children from Central Arkansas ages 7-10 years will be recruited to participate in a variety of physical activity tests including strength, flexibility, balance and endurance. During these tests, participants will perform tasks such as cycling on a stationary bike and extending and flexing their knees on a special type of chair. Body composition will be measured and blood, saliva, urine and stool samples collected. Participants and parents will be asked to complete questionnaires on physical activity, home and neighborhood environment as well as sleeping habits. Finally, participants will wear an accelerometer based monitor that will track their physical activity and sleeping patterns. One in person visit will take place at Arkansas Children's Nutrition Center (Little Rock, AR) and will last up to 8 hours. Reimbursement will be provided.
Patients with many different diseases are requesting information from health care providers, (physicians and nurses) about alternative therapies. The paucity of evidence based information requires that rigidly structured clinical trials comparing dietary supplements, herbal products and other alternative modalities with either placebo or standard of care be conducted in a timely fashion. There is a body of evidence that Silymarin is both well tolerated and efficacious for the treatment of Hepatitis C. In patients co-infected with HIV \& HCV, treatment choices are sometimes limited by intolerable toxicities of standard therapies for the treatment of HCV when combined with antiretroviral therapy for treatment of HIV. This study will seek to determine if Silymarin, an herbal product that is widely used, will be well tolerated and effective in slowing progression of liver damage in patients co-infected with HIV \& HCV.

The Informed Consent Document contains all the required elements of informed consent as required by 21CFR50. The consent clearly states that this is research, participation is voluntary and that treatment with Silymarin may not be effective. Every effort has been made to outline whatever is known about any side effects. There are very few. All study participants are followed closely, are given their test results which are also shared with primary care providers. The investigators have convened a Data and Safety Monitoring Board and the Mount Sinai IRB has approved and will monitor the study.
The invention belongs to the technical field of medicines, and relates to a levocetirizine hydrochloride oral instant film and a preparation method for the levocetirizine hydrochloride oral instant film. The levocetirizine hydrochloride oral instant film tastes good, can be fast dissolved in an oral cavity, and can be taken without water, and medicine can be rapidly released. A preparation process is convenient, easy and lower in cost. Each levocetirizine hydrochloride oral instant film contains 5 milligrams of levocetirizine hydrochloride. The invention also provides the preparation process for the levocetirizine hydrochloride oral instant film. The preparation process comprises the following steps: (1) weighing raw auxiliaries: a film forming material, a filling agent, a sweetening agent, a plasticizer, a disintegrating agent, a corrigent and levocetirizine hydrochloride; (2) dissolving levocetirizine hydrochloride, performing ion exchange on the dissolved levocetirizine hydrochloride and the corrigent, performing stirring at room temperature, performing suction filtration and washing, drying a filter cake for later use, adding the sweetening agent, the disintegrating agent, the filling agent and the film forming material, uniformly mixing, adding purified water, uniformly stirring, adding the plasticizer, leaving to stand for complete swelling, and performing degassing and film coating; (3) performing drying, film removal and cutting to obtain the levocetirizine hydrochloride oral instant film.
PROBLEM TO BE SOLVED: To make examination more efficient, e.g. shorten the examination time by reusing information which is already inputted as to an examinee by separately saving only individual information between inputted individual information and examination result information. SOLUTION: In a storage device 13, examination data (a) on an examinee to be examined is stored and held. The examination data which is stored and held includes individual information (b) on the examinee having obtained an examination result together with examination result information. The individual information (b) is identification information regarding the examinee individual such as the ID number, the name, sex, birthday, etc., and the examination result information is examination result data regarding the examinee when the examinee has various examinations for recording an electrocardiogram waveform, etc., at, for example, medical facilities.  When the examinee information is saved, data composed of only the individual information (b) are extracted from examination data including the individual information (b) and examination result information inputted to a saving management part 11 and saved as an individual information group (c) in the storage device 13.
A system and methodology for the acquisition of medical data from multiple, at-home patient measurement devices transfers the data via telephone communications to a remotely accessed data management and display system such as a Web-based data management system. The measurement device, which supports two-way communications between the patient and the database system, is extensible to support multiple plug-in medical devices and devices for patient input or identification. Collection of data is mediated through an interface device that is connected via a digital link (serial, network, or digital RF link) to single or multiple patient measurement devices. This interface device is connected to a network via wide area network means including standard phone lines. In the preferred embodiment, data transfer is mediated through pervasive DTMF phone networks. Although DTMF is the preferred format, alternative analog or digital audio tone formats may be used. The device may therefore be equipped with auto-dialer, without necessarily requiring a full chipset modem, since the vast majority of home medical appliances are low data rate devices. In alternative embodiments, however, the connection may incorporate a modem for faster data transfer, modems for DSL, cable or RF network connections, and RF or various digital connections between the medical measurement devices and the communications device itself.
Electronic health information of NSTEMI and UA patients in two chest pain centers from 2017 to 2019 was collected，After manual labeling, the characteristics of patient admission records were selected, and through the construction of one-dimensional convolution (CNN) model. Taking the multi-fold cross-validation and ROC-AUC curve as the measurement index, 75% of the data are modeled and 25% of the data are used to verify the effect of the model.
Healthy controls with no history of heart disease or heart failure. Subjects will undergo a medical history review and 1 echocardiograph procedure.
PROBLEM TO BE SOLVED: To produce the subject material readily insertable into root canals and capable of accurately determining the position of the filling material in the root canals and further performing the direct filling in the root canals by providing an electroconductive material with a proximal end and a distal end relatively to the human and animal root canals, covering the electroconductive material with an isoprene-based substrate and including the electroconductive material having the exposed distal end. SOLUTION: This filling material is obtained by including an electroconductive material 2 (e.g. titanium) having one proximal end 5 and one distal end 4 relatively to human and animal root canals, covered with one kind of isoprene-based substrate 3 (e.g. gutta-percha or balata) and having the exposed distal end 4 in a longish shape (i.e., one dimension in three- dimensional three dimensions of the material is >=2 times the respective other two dimensions). In the above material, an additive substance such as a filler (e.g. calcium hydroxide), an X-ray contrast medium (e.g. zinc powder), a pharmaceutical agent, a surfactant or a wax may be contained in the substrate 3.
Faces are a primary means of conveying social information between humans. One important factor modulating the perception of human faces is emotional expression. Face inversion also affects perception, including judgments of emotional expression, possibly through the disruption of configural processing. One intriguing inversion effect is an illusion whereby faces appear to be physically smaller when upright than when inverted. This illusion appears to be highly selective for faces. In this study, we investigated whether the emotional expression of a face (neutral, happy, afraid, and angry) modulates the magnitude of this size illusion. Results showed that for all four expressions, there was a clear bias for inverted stimuli to be judged as larger than upright ones. This demonstrates that there is no influence of emotional expression on the size underestimation of upright faces, a surprising result given that recognition of different emotional expressions is known to be affected unevenly by inversion. Results are discussed considering recent neuroimaging research which used population receptive field (pRF) mapping to investigate the neural mechanisms underlying face perception features and which may provide an explanation for how an upright face appears smaller than an inverted one. Elucidation of this effect would lead to a greater understanding of how humans communicate.
Patients undergo radical resection of colorectal cancer (open/laparoscopic) and receive standard adjuvant systemic chemotherapy comprising mFOLFOX6/CapeOx/sLV5FU2/Cape. Systemic chemotherapy will continue for 6 months.
INTRODUCTION: Infections acquired during healthcare setting stay pose significant public health threats. These infections are known as Healthcare-Associated Infections (HAI), mostly caused by pathogenic bacteria, which exhibit a wide range of antimicrobial resistance. Currently, there is no knowledge about the global cleaning process of hospitals and the bacterial diversity found in ICUs of Brazilian hospitals contributing to HAI.
OBJECTIVE: Characterize the microbiome and common antimicrobial resistance genes present in high-touch Intensive Care Unit (ICU) surfaces, and to identify the potential contamination of the sanitizers/processes used to clean hospital surfaces.
METHODS: In this national, multicenter, observational, and prospective cohort, bacterial profiles and several antimicrobial resistance genes from 41 hospitals across 16 Brazilian states were evaluated. Using high-throughput 16S rRNA amplicon sequencing and real-time PCR, the bacterial abundance and resistance genes presence were analyzed in both ICU environments and cleaning products.
RESULTS: We identified a wide diversity of microbial populations with a recurring presence of HAI-related bacteria among most of the hospitals. The median bacterial positivity rate in surface samples was high (88.24%), varying from 21.62 to 100% in different hospitals. Hospitals with the highest bacterial load in samples were also the ones with highest HAI-related abundances. Streptococcus spp., Corynebacterium spp., Staphylococcus spp., Bacillus spp., Acinetobacter spp., and bacteria from the Flavobacteriaceae family were the microorganisms most found across all hospitals. Despite each hospital particularities in bacterial composition, clustering profiles were found for surfaces and locations in the ICU. Antimicrobial resistance genes mecA, bla KPC-like, bla NDM-like, and bla OXA-23-like were the most frequently detected in surface samples. A wide variety of sanitizers were collected, with 19 different active principles in-use, and 21% of the solutions collected showed viable bacterial growth with antimicrobial resistance genes detected.
CONCLUSION: This study demonstrated a diverse and spread pattern of bacteria and antimicrobial resistance genes covering a large part of the national territory in ICU surface samples and in sanitizers solutions. This data should contribute to the adoption of surveillance programs to improve HAI control strategies and demonstrate that large-scale epidemiology studies must be performed to further understand the implications of bacterial contamination in hospital surfaces and sanitizer solutions.
INTRODUCTION: The study of the macroscopic appearance of the placenta may represent a useful tool to understand the pathophysiology of adverse pregnancy outcomes. The aim of this study was to evaluate biometry and morphology of placentas in relation to maternal, neonatal and pregnancy course characteristics.
METHODS: Clinical and placental data (biometry and macroscopic features of chorionic disk and adnexa) from unselected consecutive singleton pregnancies were recorded at the same Institution. Placental efficiency was approximated as ratio between fetal and placental weight (FPR). The total population was grouped according to the presence of any maternal comorbidity or pregnancy complication (group 1), neonatal complications diagnosed only at birth (2) and absence of any comorbidity (3). Multi-adjusted general linear and logistic regression models were performed to analyze associations between groups and placental biometry and morphology.
RESULTS: The study population counted 1008 pregnancies: 576 (57.2 %) classified as group 1, 76 (7.5 %) as group 2 and 356 (35.3 %) uncomplicated controls (group 3). In multivariate models adjusted for confounding factors, no significant differences in placental biometry and macroscopic features were observed among the three groups. Maternal BMI was significantly associated with higher placental and birth weight and lower FPR; moreover FPR was significantly higher in pregnancies carrying males compared to female neonates.
DISCUSSION: Maternal comorbidity or pregnancy disease was not associated with significant changes in placental macroscopic biometry and morphology. Conversely, maternal pregestational BMI and fetal sex impact on placental biometry and efficiency, suggesting different intrauterine adaptations in obese mothers and in male and female fetuses.
Children Autism Spectrum Disorder without Functional Constipation will be evaluated for their ASD symptoms at 4 times over 1 year. These children will be enrolled in some ASD treatment program by their parents. The treatment program is not part of the current study. Measures of F2-isoprostane, a marker of oxidative stress, will be done at each visit to determine if ASD symptom improvement relates to improvement in a child's physiology.
Breast cancer is the most common cancers among women worldwide. Although chemotherapy and surgery have greatly improved the survival rate, most types of chemotherapy have been reported to have varying degrees of cardiotoxicity. We have focused on the field of chemotherapy-related cardiomyopathy. Using the unified magnetic resonance sequences and parameters, effect of chemotherapeutic drugs on the myocardium are studies. Our team's previous pilot study has found that chemotherapy-related cardiomyopathy (CMP) may be predicted within one week after chemotherapy initiation. The specific intervention timing, and the sensitivity and specificity of the early screening indicators are to be explored. At the same time, in patients with human epidermalgrowth factor receptor-2-positive breast cancer, our team observed the change of blood pressure, exercise tolerance and myocardial structure, function and tissue characteristics in patients who used tyrosine kinase inhibitors (pyrotinib and apatinib). This is a supplement to the existing drug knowledge. We are planning to further explore whether it is related to the patient's pre-existing cardiovascular diseases, drug type, dose or dosing. There are no published data addressing the above two research areas. The overall goal is to explore the commonness and specificity of myocardial changes after chemotherapy in breast cancer patients and to predict the development of CMP through multimodality imaging and clinical indices. We aim to propose the CMP time window in respective chemotherapy among more subjects.
Subjects randomized to the placebo arm will receive a matching placebo pill (one pill) twice a day (am and pm) for one month. After one month the dose will be increased to 2 matching placebo pills twice a day (if the one pill dose was tolerated) for a further 5 months. Total treatment time is 6 months.
The invention comprises compounds of the formula <FORM:1086426/C2/1> wherein R represents a C1- 3 alkyl group, each of R1 and R11 represents a straight- or branched-chain C1- 4 alkyl group or such an alkyl group interrupted by an oxygen atom, or R1 and R11 are linked together to form an alicyclic ring, R111 represents a saturated or unsaturated C1- 6 hydrocarbon radical and n is 0 or 1, and their preparation by (a) condensing 4-chloro-3-sulphamoyl - benzene - sulphochloride of the formula <FORM:1086426/C2/2> with an amine of the formula <FORM:1086426/C2/3> or (b) by treating a sulphochloride of the formula <FORM:1086426/C2/4> with ammonia or with reagents which liberate ammonia, e.g. ammonium salts, or (c) by condensing a sulphonamide of the formula <FORM:1086426/C2/5> wherein X represents a reactive ester radical, with an alcohol of the formula HO-R111 in the presence of an acid binding agent.  Amines of the Formula III are prepared by reducing the corresponding acid amides with lithium aluminium hydride, the amides themselves being prepared by forming alkyl esters of the corresponding acids and reacting these esters with appropriate amines.  a -Methoxy-isobutyric acid is prepared by hydrolysis of tert.-2,2,2-trichlorobutanol with a solution of potassium hydroxide in methanol/water.  1 - Ethoxy - cyclopentane - carboxylic acid and a -ethoxy-a -methyl-butyric acid are similarly prepared.  Ethyl 3-methyl-3-ethoxy-butyrate is prepared by the addition of ethanol to b ,b -dimethyl-acrylic acid.
PURPOSE:To enable quick and exact quantitative determination of the antibody for the pregnancy specific protein (SPI) in many liquids to be examined by using the red blood cells of the human pregnancy specific protein obtd. by sensitizing the human pregnancy specific protein with animal red blood cells. CONSTITUTION:A reagent kit is constituted of a combination consisting of the human SPI-sensitized red blood cells obtd. by sensitizing the human SPI with animal red blood cells, a buffer soln. for measurement, a standard positive control for human plasma and a standard negative control for human plasma. The measurement up to 5mg/ml of the amt. of the antibody for the antihuman SPI contained in the specimen is made possible as a result of measuring the agglutination with the antihuman SPI antibody by a microplate method using the above-mentioned reagent kit.
The kinetic energy of liquids can be increased by several methods described in the present application. The methods include exposure to a magnetic field provided by a rotating or vibrating magnet; exposure to an electromagnetic field provided by an electrical power cord; and placement of the liquid within the vicinity of electrostatic energy and/or sound energy. A previously described method is the bubbling of electrolysis-generated water gas (Brown's Gas) into the liquid. The increased kinetic energy can be demonstrated using a previously described neutral red dye kinetic assay (NR-Kinetic assay). Energized liquids include alcohol, alcoholic beverages and water. The use of the energized solutions to enhance the alternative cellular energy (ACE) pathway in the therapy of individuals is described.
For participants with HbA1c \< 7.5%, Community Scientists will schedule a follow-up contact 6 months later. Study participation for each participant will end upon completion of 6 month follow up.
If you agree to take part in this study, you will be asked to remove your clothes from the waist up and put on a gown. A female technologist will give you an injection of Tc-99m sestamibi in a vein in your arm. This is a drug routinely used for breast imaging. About 10 minutes after your injection, you will be asked to sit in a chair for about 40 minutes. The technologist will position your breast between two small cameras. The cameras will apply a very light compression to your breast to make sure there is no movement during the picture. We will take two pictures of each breast. Each picture takes 10 minutes. You will also be asked to fill out a short questionnaire. If you are found to have additional breast lesions, your doctor and radiologist will be notified so that additional imaging or biopsies can be performed.
If the patient is randomized to no instillation, at the end of the surgery but prior to awakening from anesthesia, the surgeon will clamp the catheter and label the catheter with the clamping time. The purpose of clamping the catheter for subjects receiving usual care will be to ensure patients are masked to study arm assignment if they wake up and notice their catheter. The subject will then proceed as usual to the postoperative anesthesia care unit. A member of the subject's care team will unclamp the catheter after 1 hour. The subject will otherwise have usual pre-operative and post-operative care.
The father's phone will be stolen and the father will record the researcher's phone number. After this stage, the researcher will apply a pre-test, make the father a member of the website and show the first video about basic newborn care to the father via his phone. The first access to the website will be made under the guidance of the researcher. For membership, individuals must have an internet connection and know how to use a phone. Even though the fathers made their first viewing before being discharged from the hospital, the web page will be open for 1 month and they will be able to watch the video they want whenever they want. Individuals who visit the page and agree to participate in the study will be given a posttest at the end of the 1st month and at the end of the 4th month.