anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The necessity or desirability of withdrawal of beta-adrenergic blocking agents prior to major surgery is controversial. Beta-adrenergic receptor blockade impairs the ability of the heart to respond to beta­ adrenergically mediated reflex stimuli. This may augment the risk of general anesthesia in surgical procedures. Some patients receiving beta-adrenergic receptor blocking agents have experienced protracted severe hypotension during anesthesia. Difficulty in restarting and maintaining the heartbeat has also been reported. For these reasons, in patients undergoing elective surgery, some authorities recommend gradual withdrawal of beta-adrenergic receptor blocking agents.

  


If necessary during surgery, the effects of beta-adrenergic blocking agents may be reversed by sufficient doses of adrenergic agonists.
Numerous nano-dimensioned materials have been generated as a result of several advancements in nanoscale science such as metallic nanoparticles (mNPs) which have aided in the advancement of related research. As a result, several significant nanoscale materials are being produced commercially. It is expected that in the future, products that are nanoscale, like mNPs, will be useful in daily life. Despite certain benefits, widespread use of metallic nanoparticles and nanotechnology has negative effects and puts human health at risk because of their continual accumulation in closed biological systems, along with their complex and diverse migratory and transformation pathways. Once within the human body, nanoparticles (NPs) disrupt the body's natural biological processes and trigger inflammatory responses. These NPs can also affect the immune system by activating separate pathways that either function independently or interact with one another. Cytotoxic effects, inflammatory response, genetic material damage, and mitochondrial dysfunction are among the consequences of mNPs. Oxidative stress and reactive oxygen species (ROS) generation caused by mNPs depend upon a multitude of factors that allow NPs to get inside cells and interact with biological macromolecules and cell organelles. This review focuses on how mNPs cause inflammation and oxidative stress, as well as disrupt cellular signaling pathways that support these effects. In addition, possibilities and problems to be reduced are addressed to improve future research on the creation of safer and more environmentally friendly metal-based nanoparticles for commercial acceptance and sustainable use in medicine and drug delivery.
Patients receive oral R115777 (Tipifarnib) first followed by placebo. 200 mg/m\^2/dose BSA every 12 hours by mouth (po)on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Considering that large-scale events such as natural disasters, epidemics, and wars affect people all over the world through online news channels, it is inevitable to investigate the impact of following or avoiding negative news on well-being. This study investigated the effect of doomscrolling on mental well-being and the mediating role of mindfulness and secondary traumatic stress in social media users. A total of 400 Turkish adults completed scales to assess doomscrolling, mental well-being, mindfulness, and secondary traumatic stress. The average age of the participants was 29.42 (SD = 8.38; ranged = 18-65). Structural equation modeling was conducted to examine the mediating roles of mindfulness and secondary traumatic stress in the relationship between doomscrolling and mental well-being. Mindfulness and secondary traumatic stress fully mediated the relationship between doomscrolling and mental well-being. The results are discussed in light of existing knowledge of doomscrolling, mental well-being, mindfulness, and secondary traumatic stress. High levels of doomscrolling, which is related to an individual's mental well-being, can predict the individual's distraction from the here and now and fixation on negative news. This situation, in which mindfulness is low, is related to the individual's indirect traumatization and increased secondary traumatic stress symptoms in the face of the negative news he/she follows.
Toll-like receptors (TLRs) play a pivotal role in initiating immune responses, particularly in the context of inflammation. However, an excessive inflammation can detrimentally affect the immune homeostasis Thus, it is important to regulate TLR signaling pathways appropriately. Gingerenone A (GIA), a bioactive compound derived from ginger, has garnered significant attention due to its potential anti-inflammatory properties. In this study, we investigate modulatory effects of GIA on TLR signaling pathways. Results showed that GIA effectively suppressed TLR-mediated inflammatory responses by modulating key signaling molecules such as nuclear factor kappa B and interferon regulatory factor 3. These results indicate that GIA is a novel regulator of TLR signaling, offering promising avenues for the development of new anti-inflammatory agents.
1. A process for producing spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns, and having a density of at least 3.00 g/cc, comprising: agglomerating in the presence of water as the only additive a hydroxyapatite powder feedstock having a purity of at least 97% and having metallic impurities which do not exceed 500 ppm, to form hydroxyapatite particles having a size which does not exceed 350 microns; drying said hydroxyapatite particles; and sintering said hydroxyapatite particles at a temperature of from about 1,100 degree C to about 1,200 degree C to provide spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns and having a density of at least 3.00 g/cc. 2. The process of claim 1 wherein said hydroxyapatite powder has a purity of at least about 98%. 3. The process of claim 1 wherein said hydroxyapatite powder has metallic impurities which do not exceed 350 ppm. 4. The process of claim 3 wherein said hydroxyapatite powder has metallic impurities which do not exceed 300 ppm. 5. The process of claim 1 wherein said spherical non-porous hydroxyapatite particles have a size of from about 75 microns to about 125 microns. 6. The process of claim 1 wherein said spherical hydroxyapatite particles are sintered at a temperature of about 1200 degree C. 7. The process of claim 1 wherein said hydroxyapatite powder feedstock, prior to agglomeration, has an average particle size under 25 microns. 8. The process of claim 1 wherein said spherical non-porous hydroxyapatite particles have a density of at least 3.02 g/cc. 9. Hydroxyapatite particles produced according to the process of claim 1. 10. A process for producing spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns, and having a density of at least 3.00 g/cc, comprising: reacting calcium hydroxide having a purity of at least 95%, and having metallic impurities which do not exceed 500 ppm, with phosphoric acid, in the absence of dispersants or surfactants, to provide a hydroxyapatite powder feedstock having a purity of at least 97% and having metallic impurities which do not exceed 500 ppm; agglomerating said hydroxyapatite feedstock in the presence of water as the only additive to form hydroxyapatite particles having a size which does not exceed 350 microns; drying said hydroxyapatite particles; and sintering said hydroxyapatite at a temperature of from about 1,100 degree C to about 1,200 degree C to provide spherical, non-porous hydroxyapatite particles having a size which does not exceed 250 microns and having a density of at least 3.00 g/cc.
Virus-like particles (VLPs) have received a considerable amount of attention due to their potential application in veterinary vaccines against infectious diseases. This is the case for the rabbit haemorrhagic disease virus (RHDV), a virus which is unable to propagate in cultured cells. RHDV is the causative agent of the Rabbit Haemorrhagic Disease, one of the most economically important disease in rabbits worldwide. The RHDV capsid structure is based on a T = 3 lattice, containing 180 copies of identical VP60 subunits, similar to those of other caliciviruses. It was found that the VP1 protein of a devastating new strain, i.e. RHDVb, does not produce stable self-assembled VLPs when the capsid protein is expressed in insect cells or other systems. This application describes the generation of stable VLPs to be used as a vaccine against RHDVb. This was achieved by engineering a stable fusion protein. Collectively, this invention solves the problem of producing stable VLPs for use in vaccines against the predominant circulating strain of this virus, i.e. RHDVb.
Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis theory, neuroinflammation, and neuroplasticity, the current understanding of depression's pathogenesis remains incomplete. Importantly, depression is a gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role in the menstrual cycle, it is reasonable to postulate that its fluctuating levels could contribute to the pathogenesis of depression. Estrogen acts by binding to a diversity of receptors, which are widely distributed in the central nervous system. An abundance of research has established that estrogen and its receptors play a crucial role in depression, spanning pathogenesis and treatment. In this comprehensive review, we provide an in-depth analysis of the fundamental role of estrogen and its receptors in depression, with a focus on neuroinflammation, neuroendocrinology, and neuroplasticity. Furthermore, we discuss potential mechanisms underlying the therapeutic effects of estrogen in the treatment of depression, which may pave the way for new antidepressant drug development and alternative treatment options.
PURPOSE:To obtain a foamable bathing agent having improved storage stability of the foaming component and consisting of granules having multi-layer structure where an organic acid component and a carbonate component are separated from each other interposing one or more bathing component layers therebetween. CONSTITUTION:The objective foamable bathing agent is granules each having a multi-layer structure 3-4 layers from the viewpoint of stability, productivity, cost, shape retainability, etc.) covering the surface of the core. An organic acid component (e.g. dried citric acid, tartaric acid, malic acid, etc.) and a carbonate component (e.g. dried sodium bicarbonate, sodium sesquicarbonate, etc.) are separated from each other in the granule interposing one or more bathing component layers therebetween. The average particle diameter of the granule is 0.05-20.0mm, preferably 0.5-10.0mm from the viewpoint of appearance, stability and solubility. EFFECT:It can be stored and distributed by putting into a can, bottle, synthetic resin container, paper container, etc.
Implantation of Gestrinone pellets - Eligible patients will undergo implantation of Gestrinone pellets (bio meds Brasil, Florianópolis, Brazil) subcutaneously, in the gluteal region, using aseptic technique under local anesthesia. Patients will use 1.6mg/kg of weight to treat endometriosis. A second implantation procedure will be performed 6 months after the first, allowing evaluation of the effects of the therapy over a period of 12 months.
A dietary supplement is disclosed comprising lycopene and resveratrol in a range of ratio of lycopene: resveratrol from 1: 10 to 10: 1. Preferably, the ratio is 1: 2 to 1: 4. Lycopene is preferably of ≥ 95% purity and resveratrol is of ≥ 98% purity. Both lycopene and resveratrol may preferably comprise of nano-sized particles in crystal powder to optimize oral intake in the form of capsule or tablet. In small dosage, it should preferably include a minimum of 5 mg of lycopene and 10 mg of resveratrol. Various range of ratios of lycopene: resveratrol are provided for specific therapeutic purposes including 1: 4 for symptomatic relief of arthritis, 1: 2 for inhibiting melanoma or carcinoma malignancy, and 1: 3 for inhibiting hyperlipoidemia. Generally, our dietary supplement composition may be used as an agent for anti-ageing, anti-oxidative, inhibiting cardiovascular diseases, relieving menopause symptoms and remission of post-operative cancer patients.
With an incidence rate of 10 cases per 100,000 people per year, cancer of the pancreas is the third most common malignancy of the gastrointestinal tract. The overall survival for patients with pancreatic cancer is very poor, with a 5-year survival of 1% to 4%. Successful therapy depends on early diagnosis. The discrimination between benign and malignancies of the pancreas and the assessment of local resectability and distant metastases of the pancreatic cancer remains challenging with different imaging modalities such as ultrasound (US), endoscopic US (EUS), multidetector row computed tomography (MDCT), magnetic resonance imaging (MRI), and 18F-FDG positron emission tomography (PET). PDAC is characterized by a distinct and exuberant desmoplastic stroma, with stromal components outnumbering the pancreatic cancer cells. In PDAC, more than 90% of the tumour volume consists of cancer-associated fibroblasts (CAF). Fibroblast activation protein (FAP) is highly and selectively expressed in CAFs but is weakly expressed or not detected in normal tissues. The aim of this study was to evaluate the impact of FAPI-PET/CT on the clinical management of patients with suspected pancreatic cancer.
The product to be evaluated is bread made from wheat flour fortified according to Peruvian national standards \[Riboflavin (0.18 mg), niacin (2.25 mg), thiamine (0.18 mg), folic acid (60ug), iron (4.2 mg)\] and a previtamin mix \[Vitamin A (240 ug), Vitamin b12 (0.72 ug), zinc (5.25 mg) per daily serving\]. Participants will receive 2 slices of bread a day for 120 days. It is supplied by Panificadora Bimbo del Peru S.A.
Energy-efficient, modularized systems and method for local uncertainty quantification and outcome prediction in mobile devices are disclosed. For example, an exemplary system implementing the disclosed technology includes a mobile device with at least one sensor and a processor sitting within an energy-efficient architecture. The processor runs an uncertainty quantification (e.g. Bayesian inference) algorithm on the data collected by the sensor and characterizes the uncertainty (e.g. the full posterior distribution) around latent variables of interest. The architecture for this algorithm is de-centralized, involves simple energy-efficient procedures that are implemented in parallel and in an iterative fashion, that allows for an aggregately fast, precise, and energy-efficient hardware embodiment of uncertainty quantification. Full quantification of uncertainty in estimates enables more robust predictions and decision-making. A statistically complete representation of the data can then be sent to a human, to an actuator, or to a cloud server for subsequent decision making.
Bilateral abdominal Lap-TAP block injection near incision site with 0.25% Bupivacaine HCl (30cc) with 30ml being injected bilaterally. Remaining residual is injected into port incision sites.
The aim of this study was to investigate the DGAT1 gene polymorphism and its effects on lamb weight in kazakh and tajik sheep breeds. A total of 97 blood samples were collected from purebred (еdilbay х еdilbay) and crossbred lambs (еdilbay x gissar) breеd by the Baiserke Agro Scientific and Production Center in the Talgar District of the Almaty Region of Kazakhstan. Animals were genotyped for DGAT1-AluI polymorphism using the polymerase chain reaction-restriction length polymorphism (PCR-RFLP) method. The result of PCR-RFLP showed that purebred (еdilbay х еdilbay) sheep had three genotypes (CC, CT and TT) and crossbred sheep had two genotypes (CC and CT). The predominant genotype was CC with a frequency of 0.70 and 0.58 in purebred sheep and crossbred sheep breeds, respectively. The DGAT1 gene showed no significant association with live weight of lambs at different times in both breeds studied. However, the study showed that the CC genotype produced higher live weight at day 60 in purebred sheep (CC: 33,668 kg and CT: 32,444) and at day 120 (CC: 41,487 and CT: 40,929) in crossbred lambs. The present study was the first to investigate the polymorphism and relationships between genotypes and lamb live weights for DGAT1 gene in sheep breeds, purebred and crossbred. We conclude that further comprehensive investigations should be done for the exact evidence of the effects of DGAT1/Aluı polymorphism on lamb live weights.
PURPOSE: Studies evaluating oncological inpatient rehabilitation rarely include follow-up intervals beyond 6 months and larger proportions of patients other than those with breast cancer. Therefore, this study investigated changes in health-related quality of life (HRQoL), depression, and fear of progression of patients with breast, colorectal, or prostate cancer from the beginning to the end of oncological rehabilitation and a 9-month follow-up.
METHODS: Three hundred seventy-seven patients with breast, colorectal, or prostate cancer undergoing oncological inpatient rehabilitation (median age 61 years, 49% female) completed the EORTC QLQ-C30, the PHQ-9, and the FoP-Q-SF at each measurement point. Data analysis used 3 (tumor site) × 3 (time of measurement) repeated measures ANCOVAs with patient age and time since diagnosis as covariates. At each time point, we also compared our sample to the general population on the measures used.
RESULTS: Having controlled for the covariates, we found significant effects of tumor site, which were small except for Diarrhea. Effects of time of measurement were often significant and in part at least medium in size indicating improvement of HRQoL and depression during rehabilitation. At follow-up, some HRQoL domains and depression deteriorated. Women with breast cancer, in particular, showed a greater decrease in emotional functioning then. Compared to the general population, the sample's HRQoL and depression were significantly worse on most occasions.
CONCLUSION: Oncological inpatient rehabilitation may improve HRQoL. The subsequent and in part differential deterioration in some HRQoL domains suggests a need for further follow-up care within survivorship programs.
Gait research in young and healthy individuals increases knowledge about the neuromuscular structures involved in this motor act and thus helps to develop or adapt therapeutic approaches that increase performance and/ or optimize the rehabilitation process for people with changes in gait control, and patients with neurological diseases. The aim of this study is to investigate the effect of transcranial electrical stimulation (tDCS) on motor performance, autonomic control and attentional and executive functions in young individuals. A total of 20 individuals (10 women and 10 men) aged 20-30 years will participate in this study. Each participant will visit the laboratory on three occasions, interspersed for one week, one visit for the initial evaluation (approximately 1 hour) and two visits for data collection, lasting approximately 1 hour and 40 minutes each. All participants will be randomly allocated in a double-blind and counterbalanced manner in the different experimental conditions. In one of the visits will be composing the intervention group (n=10; 20 min) and in another visit the Sham group (n=10). Outcomes related to motor performance (bilateral coordination, static and dynamic balance and functional mobility), heart rate variability and attentional and executive functions will be evaluated. To this end, the gait will be analyzed through the OpenCap motion analysis system from filming and after, the phase coordination index will be calculated for analysis of bilateral coordination; the stabilometry test will be used to assess the static balance of the participants, using a force platform where the participant remains standing on the platform to measure the center of pressure; functional mobility will be investigated from the 30-second sit-up test, aiming to analyze the dynamic balance and functional strength of the lower body, and the Timed up and Go Test used for balance analysis, gait and functional capacity. Heart rate variability will be recorded from the use of the Polar Vantage heart rate monitor (Finland), with the capacity of the R-R temporal record. The attentional and executive functions will be evaluated from the Stroop Test tool. These are three tasks with 24 items each, where the participant will be evaluated according to how quickly he performs the task and the amount of errors presented. The data will be described as mean. The normality of all data will be verified by the Shapiro-Wilk test. ANOVA with repeated measures of two factors will be used, followed by the Bonferroni post hoc test to compare the variables collected between the different conditions of brain stimulation (with and without application of tDCS) and between gait conditions. One-factor ANOVA will be used for brain stimulation conditions; data will be tabulated via Excel and statistical analyses will be performed in the SPSS software package for Windows version 24.0 (IBM, Chicago, USA). A significant value of p \< 0.05 will be considered.
FIELD: organic chemistry, chemical technology, amino acids. SUBSTANCE: invention relates to method of synthesis of long-chain N-acylated acid amino acid (I) involving step (washing out step) of impurities removal by separation of mixture of long-chain N-acylated acid amino acid. Amino acid is prepared by fulfillment of the following steps being this amino acid comprises inorganic salts as impurity and medium consisting mainly of water and tertiary butanol for an aqueous layer and tertiary butanol for an aqueous layer and an organic layer containing long-chain N-acylated acid amino acid at temperature from 35 to 80 C: 1) step (acylation step) of condensation of acid amino acid and long-chain saturated acid halogen anhydride in mixed solvent containing mainly water and tertiary butanol in the presence of alkali; 2) step (separation step by acid precipitation) by pH value brought about to 1-6 with mineral acid for separation of mixture for an organic layer and an aqueous layer. This procedure results to preparing an organic layer containing long-chain N-acylated acid amino acid with regard to three variants of long-chain N-acylated amino acids or their salts, to two species of liquid and solid cosmetic composition and two species of detergent composition. The proposed method ensures to simplify method of synthesis of (I) and to prepare (I) without odor practically in addition to liquid detergent or cosmetic composition containing (I) being without its turbidity and precipitate formation for a long storage time and especially at low temperatures. EFFECT: improved method of synthesis. 19 cl, 7 tbl
The interventional group will receive both treatment routine physiotherapy and the Otago exercise program (OEP). The OEP is the exercise designed for strength and balance to improve mobility, functional balance and walking. The exercises included in this protocol are 17: strength, balance and walking. The participants will receive this protocol with 10 repetitions while the interval between exercises will not be fixed; patients will be given ample time to relax and recuperate before beginning another exercise, 3 times a week for six weeks and the time duration will be 30 to 45 minutes. The exercises will be progressively administered weekly.