anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pheochromocytoma (PHEO) is a malignancy characterized by the production of catecholamines from chromaffin cells located in the adrenomedullary system. The prevalence of PHEO in the general population ranges from 0.05% to 0.1%, however it is more prevalent among those with hypertension. The clinical presentation exhibits a spectrum that spans from asymptomatic to abrupt mortality. Minimally invasive laparoscopic adrenalectomy (LA) has emerged as a prominent technique in adrenal illness surgery due to its reduced surgical morbidity and death rates, making it the favored method in this field. The initial exploration of transperitoneal laparoscopic adrenalectomy (TLA) was conducted by Gagner et al. The LA procedure encompasses many transabdominal and retroperitoneal techniques, whereas TLA is favored by surgeons due to its well-known anatomy and expansive working area. Nevertheless, PHEO surgery remains a formidable task for surgeons and anesthesiologists due to its established correlation with hemodynamic instability (HI), resulting in symptoms such as abrupt hypertension or tachycardia, as well as severe and protracted hypotension following tumor excision. Skilled surgeons and anesthesiologists enhance the outcomes and reduce the occurrence of hypotension. The research has documented a multitude of additional risk factors associated with HI. The observed variability could perhaps be attributed to the lack of consistent anesthesiological and surgical protocols, as well as variations in the definitions of HI. Laparoscopic adrenalectomy does not have any absolute contraindications. However, it is worth noting that up to 20% of patients may need to undergo conversion to an open procedure. There has been no specific evaluation of the incidence and risk factors of perioperative hypotension (both intraoperative and postoperative) and conversion rate in a large group of patients undergoing laparoscopic right adrenalectomy (LRA) or laparoscopic left adrenalectomy (LLA) for managing pheochromocytoma resection.
Although the safety of phakic intraocular lenses (pIOLs) has been continuously improved over 70-years of development, high endothelial cell losses can occur even with current pIOL models. Numerous studies have demonstrated that the distance of a pIOL to the corneal endothelium plays a crucial role in the extent of endothelial cell loss. For this reason alone, higher endothelial cell loss tends to be observed with anterior chamber lenses than with posterior chamber lenses. Adequate preoperative anterior chamber depth is essential, at least for iris-fixed pIOLs, in order to ensure a safe distance from the endothelium. However, the anterior chamber becomes shallower with age and therefore it may be useful to consider patient age in the safety criteria. Although endothelial cell loss is generally low with current pIOL models, regular monitoring of the endothelial cell density remains essential due to large interindividual differences in patients with pIOLs. If the endothelial cell loss is greater than expected and the follow-up visits confirm the trend, the pIOL should be explanted without delay. The endothelial reserve should be considered on an individual basis by taking into account patient age, physiological endothelial cell loss, and loss due to further surgery. With careful indication and long-term patient care, pIOLs remain a safe treatment option.
FIELD: pharmaceutics.SUBSTANCE: proposed group of inventions relates to the pharmaceutical industry, namely, to the use of a composition for the prevention and/or treatment of a disease caused byP. aeruginosabacteria. The use of a CBD-based composition containing CBD in concentration from 1.9 mcg/ml to 200 mg/ml for the prevention and/or treatment of a disease caused byP. aeruginosabacteria is proposed, where the disease or disorder is selected from a group consisting of nosocomial infection, respiratory tract infections, skin and soft tissue infections, wound infections, dental and buccal infections, otorhinolaryngological infections, urinary and/or prostate tract infections, gastrointestinal infections, biliary tract infections, eye infections, bacteremia, sepsis, central nervous system infections and endocarditis. A method for the prevention and/or treatment of a disease caused byP. aeruginosabacteria is proposed, where the disease or disorder is selected from a group consisting of nosocomial infection, respiratory tract infections, skin and soft tissue infections, wound infections, dental and buccal infections, otorhinolaryngological infections, urinary and/or prostate tract infections, gastrointestinal infections, biliary tract infections, eye infections, bacteremia, sepsis, central nervous system infections and endocarditis, wherein the specified method includes the injection of therapeutically effective amount of the composition containing CBD in concentration from 1.9 mcg/ml to 200 mg/ml, to a subject who needs it.EFFECT: above-described use and method are effective for inhibiting the formation of biofilm and/or virulence ofP. aeruginosa, for the prevention and/or treatment of a disease caused byP. aeruginosabacteria.9 cl, 2 dwg, 1 tbl, 3 ex
This additional cohort in Part A of the study will only be conducted to allow for evaluation of additional dose levels or repeated evaluation of a dose level already studied. Doses will be selected based on the safety, tolerability, and PK data from Part A and/or previous Part B cohorts. Eight subjects will be randomized equally (1:1:1:1) to one of the 4 placebo-controlled dose sequences with 2 subjects in each sequence and each subject having four dose periods (3 active dose of GSK2982772 + 1 placebo dose). The selection of appropriate daily doses will be performed upon consideration of available safety and tolerability and PK data from Part A and/or any preceding repeat dose cohorts in Part B.
To provide a cosmetic composition having a function of oil and moisture absorption and malodor removal, which is capable of suppressing the caking phenomenon by absorbing and removing oil and water generated from a human body, and at the same time excellent in the effect of removing malodor generated from the human body.SOLUTION: A cosmetic composition having an oil and moisture absorption and malodor removal function according to the present invention comprises 10-50 pts.wt. of a porous powder, 10-60 pts.wt. of zeolite, and 0.1-6 pts.wt. of titanium dioxide with respect to 100 pts.wt. of the whole amount of the cosmetic composition. The cosmetic composition is excellent in the removal effect for various malodors by the physical, chemical, and biochemical adsorption and deodorizing effect, and is free from the development of agglomeration and caking, thus making it possible to provide convenience in use to the consumers.SELECTED DRAWING: Figure 1
The day-to-day change of blood glucose is associated with the frequency of vascular complications and the quality of life of diabetic patients. In this study the frequency of hypoglycemic events in combination with postprandial hyperglycemia in type 2 diabetic patients on oral insulinotropic therapy will be observed. Using more sophisticated technology than before the probability of type 2 diabetic patients on glibenclamide to experience hypoglycemic episodes will be registered. Hypoglycemia is prone to cardiovascular complications in type 2 diabetic patients due to concomitant dysregulation of blood flow. With standardized test meals followed by exercise in a clinical setting hormonal counterregulation and cardiovascular parameters associated with hypoglycemia will be identified. The acute effect of different conditions of exercise and a single dose of either glibenclamide or placebo will be followed each day during the total three-day observation period. Thus we will evaluate the frequency of and the risk factors associated with hypoglycemia and meal-related hyperglycemia in type 2 diabetic patients.
Surgical site infections (SSIs) pose significant risks to patients undergoing colorectal cancer (CRC) surgery. With increasing evidence on the benefits of oral probiotics in various clinical contexts, there is a need to assess their efficacy and safety in reducing SSIs following CRC surgery. A systematic review and meta-analysis were conducted in line with PRISMA guidelines using the PICO framework. On 19 September 2023, four major databases (PubMed, Embase, Web of Science and Cochrane Library) were searched without any temporal or language restrictions. Rigorous inclusion and exclusion criteria were employed. Data extraction was independently undertaken by two assessors, and any discrepancies were discussed. The Cochrane Collaboration's risk of bias instrument was utilized to assess study quality. The meta-analysis incorporated a fixed-effects model or random-effects model based on the I2 statistic to assess heterogeneity. The initial search yielded 1282 articles, of which 10 met the inclusion criteria and were analysed. Probiotic administration not only significantly reduced the incidence of SSIs but also curtailed the duration of hospital stays. Moreover, the subgroup analysis indicated that interventions employing multiple strains of probiotics were more effective in reducing postoperative infections than those utilizing a single strain. Probiotics effectively prevent postoperative infections and shorten hospital stays. Multi-strain probiotics outperform single strain in efficacy. Future studies should focus on their safety and optimal clinical use.
Background: Gastric cancer's (GC) cause is unknown, but its complexity indicates that, in addition to environmental factors, it may have genetic origins. Scientists are studying single-nucleotide polymorphisms (SNPs) in the antisense noncoding RNA in the INK4 locus (ANRIL) gene, which encodes a long noncoding RNA molecule. They found a link between the ANRIL gene product and some polymorphisms and GC, suggesting genetic changes may lead to precancerous conditions. Methods: In a case-control research that included 250 patients with GC and 210 controls who were age- and gender-matched, four SNPs within the ANRIL gene were genotyped. These SNPs were rs1333049, rs496892, rs2383207, and rs2151280. Tetra-primer amplification refractory mutation system-PCR was utilized to carry out the process of genotyping. Results: It was found that the chance of developing GC was connected with three SNPs rs2151280, rs1333049, and rs496892. Nevertheless, rs2383207 did not demonstrate any meaningful connection. In addition, whereas CCTC and TTCC haplotypes were shown to be less common, certain haplotypes that contained these SNPs (TTCG, TCTC, and TTTC) displayed a considerably higher prevalence in the cancer group in comparison to the control group. Conclusion: This study showed novel associations between specific ANRIL gene polymorphisms (SNPs) and the risk of GC. These findings shed light on the potential role of ANRIL SNPs in GC risk and highlight the need for additional research to clarify the underlying functional processes. Understanding these functional processes might lead to developing novel diagnostic or treatment approaches for this cancer.
Split-thickness skin grafting is the current standard of care for the reconstructive procedures in managing burn injuries and traumatic tissue defects. Harvesting split-thickness skin creates a new partial thickness wound that is referred to as the donor site.(1) Donor site pain is one of the most distressing symptoms reported by patients in the early postoperative period.4,5 Larger donor sites stimulate a greater number of pain receptors and consequently pain is proportional to the size of the graft harvested.6 Often, the donor site is reported to be more painful than the recipient site,7 affecting early mobilization, sleep, and need for analgesics postoperatively.(1) Most commonly split thickness auto-grafts are harvested from a convenient and minimally aesthetically intrusive site; often the lateral thigh area, which is innervated by lateral femoral cutaneous nerve (LFCN). However if a larger graft area in needed then it will be obtained from the anterior aspect of the thigh, which is innervated by the femoral nerve.(2) Regional nerve blockade has been proposed for skin graft harvest and proofed to provide better and longer standing analgesia.(2) Application of fascia iliaca compartment block involves the distribution of anesthesia to the territories of the femoral and lateral cutaneous nerves(3) American society of regional anesthesia and pain medicine recommendations on local anesthetics in pediatric regional anesthesia in 2018 stated that the ultrasound guided fascial plane blocks as fascia iliaca block can be successfully and safely performed using a recommended dose of 0.25-0.75 mg/kg of bupivacaine 0.25%.(4) Prolongation of analgesia after any surgery is the goal of any phsyician ,and Fascia Iliaca Block (FIB), which is widely used for postoperative analgesia in many surgeries, is a nerve block technique with proven efficacy. but which has the superior effect of numbing the pain ..Is it the fascia iliaca erve block or the caudal block .

The objective of this study is to compare post operative analgesic effect and safety of fascia iliaca nerve block versus caudal block in pediatric patient undergoing a graft surgery .
BACKGROUND: A distal anastomotic new entry tear (DANE) can occur at the time of surgical repair for acute type A aortic dissection (ATAAD). This study aimed to compare the occurrence of DANE following a standard hemiarch repair with that following a hemiarch repair with an uncovered arch dissection stent.
METHODS: All patients who received a hemiarch repair or a hemiarch repair with an Ascyrus Medical Dissection Stent (AMDS) for ATAAD from 2017 to 2021 were included. Baseline and intra- and postoperative characteristics were collected. All available pre- and postoperative computed tomographic scans were analysed. The primary outcome measures were the incidence of DANE, positive aortic remodelling, mortality, and aortic reintervention rates at last follow-up.
RESULTS: A total of 114 patients underwent repair of Debakey I ATAAD during the study period with either an isolated hemiarch (n = 77) or a hemiarch with AMDS (n = 37). There was no significant difference in mortality (P = 0.768) or other in-hospital adverse events. During the follow-up period, DANE occurred in 43.3% (n = 26) of the isolated hemiarch group and in 11.8% (n = 4) of the hemiarch with AMDS group (P = 0.002). The incidence of false lumen thrombosis and obliteration favoured the AMDS group in the aortic arch (P = 0.029), the proximal descending thoracic aorta (P = 0.031), and level of pulmonary artery bifurcation (P = 0.044).
CONCLUSIONS: The incidence of DANE is significantly reduced with the addition of an AMDS at the time of hemiarch repair for ATAAD repair. Further follow-up is necessary to identify late aortic complications that may have been prevented by reducing the incidence of postoperative DANE.
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic activity in animal models. The mechanism of action of ketorolac, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. The biological activity of ketorolac tromethamine is associated with the S-form. 

Ketorolac tromethamine possesses no sedative or anxiolytic properties.

The peak analgesic effect of ketorolac tromethamine occurs within 2 to 3 hours and is not statistically significantly different over the recommended dosage range of ketorolac tromethamine. The greatest difference between large and small doses of ketorolac tromethamine is in the duration of analgesia.
Rural villages in which Gram Vikas has fully implemented its water supply and sanitation (Mantra) intervention. Intervention villages must: 1) be within 3 hours travel to the study office in Brahmapur, 2) have started the intervention by January 2003, and 3) have completed the intervention by January 2013.
The invention provides a new purpose of poplar leaf total phenolic extracts to treat cardiovascular diseases and the extraction method. The invention relates to a purpose poplar leaf total phenolic extracts to treat cardiovascular diseases and the extraction method. The invention provides a new purpose of poplar leaf extracts and a high content effective components extraction method. The poplar leaf total phenolic extracts are used to treat cardiovascular diseases. The extraction method is: 1. decoction; 2. decocted fluid filtration and concentration; 3. column chromatography elution; 4. cooling-sedimentation after pH value acid regulation; 5. Cooling-sedimentation after pH value alkali regulation, and cooling-sedimentation after pH value acid regulation with supernatant solution; 6. pump filtration and filtration and washing with alcohol. The content of the phenolic compounds prepared in the extraction method is higher than 95 percent. The extracts of the invention has the functions of resisting inflammatory, activating blood, removing stagnated blood, antioxidation, alleviating myocardial ischemia, improving the symptoms of arrhythmia and enhancing anoxia test of patients, and is applicable to treat cardiovascular diseases like coronary heart disease, etc.
The baculovirus-insect cell vector system is useful as a high efficiency eukaryotic cloning and expression method for the production of the recombinant proteins. A major application of this system is in the development of rDNA vaccines for important human and animal diseas­es. This system is also useful to express the circum­sporozoite antigen of a parasite that causes malaria in humans,  Plasmodium falciparum . The resulting recombi­nant protein consists of full-length circumsporozoite antigen. The results indicate high levels of expression into recombinant products which closely resemble the authentic product. Furthermore, it has been demonstrat­ed to effect purification of the recombinant product to near homogeneity. The expression of this gene by the baculorvirus-insect cell vector system yields these desirable results because this gene is normally ex­pressed by insects. Recombinant circumsporozoite pro­teins produced in this manner have application as ingre­dients for sub-unit vaccines to protect against malaria, and as an ingredient for malaria diagnosis.
This is a multicenter, randomized clinical trial comparing the efficacy and safety with transfer of embryos selected by next generation sequence (NGS) and morphologic criteria versus by morphological criteria alone. Subjects who obtain 3 or more good-quality blastocysts will be randomized to PGS or IVF group. All embryos will be frozen and a single thawed blastocyst will be transferred in both PGS and IVF group. Subjects in the PGS group will have 3 blastocysts sequenced and euploid embryos will be subsequently transferred. Subjects in the IVF group will have blastocysts selected by morphology assessment. The cumulative live birth rate will be counted after transfers of all euploid embryo in the PGS group and 3 blastocysts in the IVF group within 1 year after randomization.
FIELD: medicine. SUBSTANCE: agent has, weight pts.: flavin derivatives, 0.2-20.0; coenzyme CO 2 , 1.0-10.0; NAD, 0.5-10.0; cytochrome, 5.0-20.0; and inosine 60-92. Agent is tested under condition of hyperbaric hypoxia at height 11500 m, at the rise rate 50 m/s without Q 10  absorption. Agent shows the enhanced effectiveness with respect to time reserve and hypoxic protection coefficient of animals. Its effect exceeds protective effects of sodium hydroxybutyrate and jancarb by many times. Agent can be used for prevention of tissue hypoxic damage and complete recovery of energy supply homeostasis system under hypoxia and ischemic damages. EFFECT: enhanced effectiveness of agent. 5 cl
Participants in this arm will be shown standard AI model predictions during 3 patient clinical vignettes within the survey and systematically biased AI model predictions during 3 clinical vignettes. When shown systematically biased AI model predictions, the model will be biased against pneumonia, always predicting that pneumonia is present with high likelihood in patients 80 years or older. Standard predictions will be shown for the other 2 diagnoses. Participants in this arm will not be shown an AI explanation when shown AI model predictions.
Participants will undergo six electrostimulation sessions, which will take place once a week and will last 20 minutes. Participants complete a set of questionnaires at the following times: pre-test (T0), post-test (T1), and 1-month post-intervention follow-up (T2). The first session will include a psychoeducational component, where it will be explained that psychological morbidity and stress influence the immune system, with repercussions on QoL.
Polio vaccine booster will be administered 1 week prior to PVSRIPO injection. On the day of PVSRIPO injection (Day 0), a pre-treatment biopsy is obtained. PVSRIPO in injected into the tumor mass at a dose of 1x10\^8 TCID50. On day 14, women will undergo standard-of-care surgical resection of PVSRIPO-treated tumor.
beta -Carotene, lycopene and canthaxanthin, as representative carotenoids, and to a lesser extent, retinoic acid, a representative retinoid, undergo extensive oxidation to yield substances, insofar as oxidized  beta -carotene is a model, which have properties useful as non-toxic agents active against cell proliferation, tumors, and tumorigenic viruses, and useful as promoters of cell differentiation. It is evident from chemical analysis of the highly oxidized  beta -carotene product mixture that none of the various forms of vitamin A are present or are present only in minor amounts. Furthermore, the biological activities of oxidized canthaxanthin and lycopene, which cannot form vitamin A, indicate the presence of active substances that are different from vitamin A. Although the cytostatic and differentiation promotion activities of oxidized  beta -carotene resemble those of vitamin A itself, generally the effects are more powerful for oxidized  beta -carotene in a wide variety of circumstances. Unlike vitamin A, the oxidized  beta -carotene of the invention is non-toxic. The oxidized carotenoid is a mixture of compounds which can be divided into a number of fractions according to molecular weight and polarity. The fractions exhibit anticancer activity comparable to, or higher, than the activity of unfractionated oxidized carotenoid.
PURPOSE: To obtain a novel compd. deriv. which consists of a specific N-substd. amide and is useful for prevention and treatment of the symptoms of a patient oranimal due to nervous endoneurium edema induced by mast cell degranulation due to peripheral nerve disorder. CONSTITUTION: The desired aminoalcohol N-acyl deriv. which is expressed by formula I (R2 is a 1 to 20C hydroxyalkyl of which one or more of arom. groups may be substd. with an alkyl chain, a 1 to 20C hydroxyaryl which may be substd. with one or more of alkyl groups; R3 is H, R2 ; formula II is the acryl residue of a monocarboxylic acid) and is used for treating or preventing the symptom of human and animal due to the nervous endoneurium edema induced by the mast cell degranulation due to the peripheral nerve disorder is obtd. by bringing a monocarboxylic acid, such as palmitic acid, into reaction for 5 to 6 hour in the presence of ethanolamine in ethyl alcohol in a nitrogen atmosphere, then extracting the reaction product from the reaction mixture and crystallizing the product by using 95% ethanol at 0 deg.C.
Subjects in the sham arm will be administered sham transcranial direct current stimulation (tDCS) (i.e., tDCS will be administered for 30 seconds and then will automatically turn off). Sham group will have identical intervention of engagement in 10 1-hour computerized cognitive remediation therapy sessions during sham tDCS as with the active tDCS condition.