anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In our study, it was aimed to evaluate respiratory functions and respiratory muscle strength in patients diagnosed with temporomandibular dysfunction (TMD) and to compare them with healthy individuals. The study was conducted with a total of 46 participants, 23 of whom were diagnosed with TMD and 23 healthy individuals, at Batman Training and Research Hospital between August 2021 and December 2021. In the evaluation, the demographic information and clinical findings of the participants were recorded. Mandible movements were evaluated with a digital caliper. For TMJ, the Visual Analogue Scale (VAS) was used to measure the severity of pain at rest and during activity. Cervical lordosis and shoulder posture assessment was done by distance measurement. Fonseca Anamnestic Index was used for TMD severity classification. Spirometric measurement was performed to evaluate respiratory functions of all participants and intraoral pressure measurement was performed to determine respiratory muscle strength. Statistical analyzes were performed using the IBM SPSS Statistics 26 program. Significance level was accepted as p\<0.05.
The National Assessment of Educational Progress estimates that only 35% of fourth graders in the United States are able to read at or above grade level. Children's future academic success is accurately predicted by performance in the first three years of school. A student is four times more likely to drop out of high school if he or she is not reading proficiently by the end of third grade. High school dropouts are three times more likely to be unemployed than college graduates per US Bureau of Labor Statistics in 2018, and those who are employed earn an average of 61% less over the course of their lifetimes compared to their college-educated peers per US Census Bureau in 2012. Eighty-five percent of juveniles facing trial in the court system are functionally illiterate per National Criminal Justice Reference Service in 2003, and adolescent girls with low literacy skills are five times more likely to become pregnant than teenagers who can read at or above grade level.

Despite the preponderance of data expounding a literacy crisis in the US, the status quo of reading instruction in US elementary schools has not been effective in remediating functional illiteracy. In classrooms averaging 21.6 students, teachers are unable to provide the individualized instruction that is necessary to meet the learning needs of at-risk students. Reading specialists who work with children one-on-one and in small groups employ methods similar to those of classroom teachers, requiring children to sit quietly and sustain their attention on small print. These demands are difficult for children experiencing challenges with self-regulation, and school environments requiring these behaviors for several hours each day may inculcate feelings of frustration and failure in the children who most need to develop a sense of self-efficacy as readers with full membership in the world of print. In this study, twenty-four first graders will be assigned by chance to a reading or no-reading group.
The Working Memory Training, includes both auditive and visual tasks, administrated on a computer, under guidance. 5 x 45 minutes per week, for 5 weeks. The placebo group will train at an fixed level (non-adaptive), but with otherwise identical computer programs.
Scenario 2: chemoradiation followed by resection and follow-up - Study-specific liquid biopsies will be collected in 50 patients. Samples will be acquired before the start of chemoradiation, before surgery, 6-8 weeks, 6 and 12 months after surgery. A subgroup of patients will undertake adjuvant immunotherapy and will constitute Group 3. Timing of sampling will be adjusted accordingly as per study flowcharts.
PURPOSE:To enable manufacturing by a simple method and to attain to enhance storage stability by strongly fixing an antigen to a support, in regenerating crystalline fibroin from an aqueous fibroin solution, by including an antigen in the fibroin. CONSTITUTION:An antigen is prepared in a state included in crystalline fibroin when said fibroin is regenerated from an aqueous fibroin solution. The form of the immobilized antigen for immunoassay is pref. a film form or the membrane applied to a support in order to simplify and facilitate operation for separating an immobilized antigen-antibody composite from the free antibody in a specimen or washing and removing the same. Because the immobilized antigen is generally used in an aqueous solution, it is required that the regenerated fibroin of a carrier has water resistance. Therefore, fibroin receives regeneration treatment so that the crystallization degree thereof is at least 20% or more.
The perioperative environment, often anxiety-provoking for adults, may be quite frightening for children. The detrimental effects of preoperative anxiety are not confined to the preoperative period. Anxiety during induction of anesthesia is correlated with increased distress early in the postoperative period, (Holms Knud, Kain) and maladaptive behavior will follow for the first 2 weeks following surgery in up to 54% of children.

Many preoperative systems allow parental, pharmacologic, and anticipatory interventions to facilitate a relaxed perioperative environment for children. Unfortunately, scheduling conflicts, side effects, and limited resources conspire to limit their usefulness. For example, only 10% of respondents in a recent survey used parental presence during induction of anesthesia (PPIA) for a majority of their patients. This may be due to the belief by some that parental anxiety may in fact increase children's anxiety. (Bevans) According to the same survey, only 50% of children undergoing surgery receive sedating premedication. (Kain). Distraction techniques, such as the use of toys or video games, may also decrease perioperative anxiety, however their effectiveness during induction of anesthesia is not well characterized. The efficacy of toys and video games is somewhat dependent upon the child reaching certain developmental milestones. Anesthesiologists continue to search for an easy and comprehensive method for anxiety reduction in the pediatric surgical population. We propose that specially trained professional clowns may allay preoperative anxiety and result in a smooth anesthetic induction.
The present application relates to improving healthcare practices in clinical facilities. In a facility that utilizes electronic patient charts (16), a correlation processor (24) discovers correlations between events as defined by a user of the system. The user first selects an anchor event. Then the user selects a related event. Both the anchor events and the related events can be run through appropriate filters to eliminate unwanted results. The user then defines a relationship between the anchor event and the related event. The correlation processor (24) then searches through the patient charts (16) for the correlation as defined by the user. Results are displayed for the user in a format designated by the user.
Sequence-specific polymers are proving to be a powerful approach to assembly and manipulation of matter on the nanometer scale. This has been most impressive in the case of DNA, and progress has been made toward templating inorganic nanoparticles using DNA nanostructures. One obstacle to this progress is that inorganic nanomaterials are often incompatible with DNA assembly conditions, which involve aqueous solutions high in either or both monovalent and divalent salt. Synthetic oligopeptide ligands have been shown by others to improve nanoparticle stability in high concentrations of monovalent salt. Ligands that are peptoids, or sequence-specific N-functional glycine oligomers, allow precise and flexible control over the arrangement of binding groups, steric spacers, charge, and other functionality. We have synthesized short peptoids that can prevent the aggregation of gold nanoparticles in high-salt environments including divalent salt, and allow co-adsorption of a single DNA molecule. This degree of precision and versatility is likely to prove essential in bottom-up assembly of nanostructures and in biomedical applications of nanomaterials.
The invention discloses a heat-not-burn cigarette additive and a preparation method and application thereof. A component A comprises one or multiple of reed rhizome, dutchmanspipe fruit, root of Chinese Trichosanthes, fructus gardeniae, herba violae and lasiosphaera seu calvatia. A component B comprises one or multiple of climbing groundsel herb, Rabdosia rubescens herb, Radix Sophorae Subprostratae and willowleaf Swallowwort rhizome. A component C comprises one or multiple of Immature fruit of Medicine Terminalia, franchet groundcherry persistent calyx or fruit, Inula flower and kelp. Particles of the three components are enzymatically hydrolyzed via enzyme solution 0.01%-10.00% in mass concentration, then distilling is performed to extract volatile oil, the volatile oil is prepared into the additive, and the additive is added into heating tobacco material according to a weight ratio of 0.0001%-3%. Effective components of natural plants, which have certain effect on relieving harm to the respiratory system, are added to heat-not-burn cigarettes to prepare the heat-not-burn cigarettes effective in relieving the harm of tobacco to the respiratory system, and the fragrance characteristics of the heat-not-burn cigarettes are beneficially enriched.
BACKGROUND: Malnutrition is highly prevalent and associated with complications and mortality in patients with cirrhosis.
METHODS: This was a prospective observational study. Patients with cirrhosis were screened using the Nutritional Risk Screening 2002, the Royal Free Hospital-Nutritional Prioritizing Tool and the Skeletal Muscle Index. Then, the sensitivity, specificity, positive and negative predictive values, and consistency with the Global Leadership Initiative on Malnutrition criteria results were calculated. We also analysed the association between nutritional status and short-term prognosis.
RESULTS: We enrolled 125 patients with cirrhosis, of whom 59.20% and 60.00% were malnourished based on the Global Leadership Initiative on Malnutrition criteria and Skeletal Muscle Index. Some 53.60% and 65.60%, respectively, were classified medium-to-high nutritional risk by Nutritional Risk Screening 2002 and the Royal Free Hospital-Nutritional Prioritizing Tool. The Royal Free Hospital-Nutritional Prioritizing Tool had the best predictive value, and it was more sensitive and had a better negative predictive value than the Nutritional Risk Screening 2002 Tool. The Skeletal Muscle Index also had good sensitivity and predictive value. The Royal Free Hospital-Nutritional Prioritizing Tool, Skeletal Muscle Index and Global Leadership Initiative on Malnutrition criteria showed high concordance. The 3- and 6-month mortality rates were significantly higher for patients with moderate-to-high nutritional risk or malnutrition, regardless of the tool.
CONCLUSIONS: When assessing cirrhosis with the Global Leadership Initiative on Malnutrition criteria, the Royal Free Hospital-Nutritional Prioritizing Tool is best for nutritional screening and the Skeletal Muscle Index is also a good nutritional assessment tool.
PURPOSE:To provide a pack cosmetic which can be removed without washing, can be dried in a short time, and can form a dried film giving moderate astringent feeling to the skin, by adding crystalline cellulose to a peel-type pack containing an alginic acid salt. CONSTITUTION:The objective pack cosmetic can be obtained by reacting a water-soluble alginic acid salt (e.g. sodium alginate) with >=2-valent metal salt (e.g. calcium citrate) in the presence of water, and mixing the resultant film- forming gel of metal alginate (e.g. calcium alginate) with crystalline cellulose (microcrystalline cellulose powder). The amount of the water-soluble alginic acid salt, the >=2-valent metal salt and the crystalline cellulose are preferably 5-20pts.wt., 15-35pts.wt., and 45-70pts.wt., respectively. When the >=2-valent metal salt is a highly reactive salt such as calcium sulfate, etc., it is preferable to add 0-8pts.wt. of an alkali metal salt as a reaction regulator to suppress the gelling reaction.
All study subjects will take a 10mg pill by mouth twice daily over a 6 week period. Subjects will receive either placebo or S -Equol. They will not know which they are receiving.
Intensive counseling in a 5-day per week program plus abstinence-contingent rent payment in a community recovery house. Intervention lasts 12 weeks with follow-up at 12 and 24 weeks post treatment entry.
PROBLEM TO BE SOLVED: To obtain a medicine capable of markedly treating and preventing stomatitis especially caused by a cancer chemotherapy and/or radiation therapy by using zinc salt of L-carnocine used as a gastic ulcer treating agent, etc., as an active ingredient. SOLUTION: This stomatitis treating and preventing agent contains zinc salt of L-carnosine, or the zinc salt of L-carnosine with sodium alginate as active ingredients. The zinc salt of L-carnosine is a salt consisting of the L- carnosine consisting of β-alanine and L-histidine, with zinc. The sodium alginate is a polysaccharide constituting a cell membrane of brown algae. The medicine is preferably used as a gargling preparation or an ointment used in an oral cavity. Thus, an objective medicine having a low toxicity and a high safety, can be obtained.
Epileptogenic zones (EZs), where epileptic seizures cease after resection, are localized by assessing the seizure-onset zone using ictal electroencephalography (EEG). Owing to the difficulty in capturing unpredictable seizures, biomarkers capable of identifying EZs from interictal EEG are anticipated. Recent studies using intracranial EEG have identified several potential candidate biomarkers for epileptogenicity. High-frequency oscillation (HFO) was initially expected to be a robust biomarker of abnormal excitatory activity in the ictogenic region. However, HFO-guided resection failed to improve seizure prognosis. Meanwhile, the regularity of low-gamma oscillations (30-80 Hz) indicates inhibitory interneurons' hypersynchronization, which could be used to localize the EZ. Besides resting-state EEG assessments, evoked potentials elicited by single-pulse electrical stimulation, such as corticocortical evoked potentials (CCEP), became valuable tools for assessing epileptogenic regions. CCEP responses recorded in the cortex remote from the stimulation site indicate functional connectivity, revealing increased internal connectivity within the ictogenic region and elevated inhibitory input from the non-involved regions to the ictogenic region. Conversely, large responses close to the stimulation site reflect local excitability, manifesting as an increased N1 amplitude and overriding HFO. Further research is required to establish whether these novel electrophysiological methods, either individually or in combination, can function as robust biomarkers of epileptogenicity and hold promise for improving seizure prognosis.
BACKGROUND: Activated protein C (APC) is one of the mechanisms contributing to coagulopathy, which is associated with high mortality. The counteraction of the APC pathway could help ameliorate bleeding. However, patients also transform frequently from a hemorrhagic state to a prothrombotic state at a later time. Therefore, a prohemostatic therapeutic intervention should take this thrombotic risk into consideration.
OBJECTIVES: CT-001 is a novel factor VIIa (FVIIa) with enhanced activity and desialylated N-glycans for rapid clearance. We assessed CT-001 clearance in multiple species and its ability to reverse APC-mediated coagulopathic blood loss.
METHODS: The N-glycans on CT-001 were characterized by liquid chromatography-mass spectrometry. Three species were used to evaluate the pharmacokinetics of the molecule. The potency and efficacy of CT-001 under APC pathway-induced coagulopathic conditions were assessed by coagulation assays and bleeding models.
RESULTS: The N-glycosylation sites of CT-001 had high occupancy of desialylated N-glycans. CT-001 exhibited 5 to 16 times higher plasma clearance in human tissue factor knockin mice, rats, and cynomolgus monkeys than wildtype FVIIa. CT-001 corrected the activated partial thromboplastin time and thrombin generation of coagulopathic plasma to normal in in vitro studies. In an APC-mediated saphenous vein bleeding model, 3 mg/kg of CT-001 reduced bleeding time in comparison with wildtype FVIIa. The correction of bleeding by CT-001 was also observed in a coagulopathic tail amputation severe hemorrhage mouse model. The efficacy of CT-001 is independent of the presence of tranexamic acid, and the combination of CT-001 and tranexamic acid does not lead to increased thrombogenicity.
CONCLUSION: CT-001 corrected APC pathway-mediated coagulopathic conditions in preclinical studies and could be a potentially safe and effective procoagulant agent for addressing APC-mediated bleeding.
A traditional Chinese medicine mouth wash for diminishing inflammation and promoting the secretion of saliva and a preparation method thereof belong to the technical field of oral care products. The effective components of the traditional Chinese medicine are prepared from 14 traditional Chinese medicine raw materials of dwarf lilyturf tuber, asparagus, dark plum fruit, boat-fruited sterculia seed, grosvenor momordica fruit, coastal glehnia root, dendrobium, cogongrass rhizome, tangerine peel, mint, chrysanthemum, honeysuckle, bletilla and dragon's blood. The traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva is obtained by extracting the traditional Chinese medicine to obtain a traditional Chinese medicine extract, adding citric acid, xylitol and domiphen bromide and uniformly mixing. The compatibility of the prescription is characterized in that: sweet-cold is compatible with pungent-warm, and sweet-cold is the main reason; the evacuation is matched with the clearing, and the clearing is considered; has the effects of clearing away heat and toxic materials, promoting salivation, quenching thirst, relieving inflammation, and inhibiting bacteria. The traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva has the functions of clearing away heat and toxic materials, promoting the secretion of saliva to quench thirst, diminishing inflammation and inhibiting bacteria, has no irritation, does not generate drug resistance, and has no toxic or side effect on a human body. Can effectively inhibit oral bacteria, remove oral odor, has good effects of cleaning and caring oral cavity, and simultaneously prevents occurrence and development of oral diseases.
The invention discloses a taditional Chinese medicine fumigation lotion used for treating children rubella. Rubella is considered as wing fever in Chinese medical science. It is commonly considered that the disease is caused by rubella toxin which is brought from mouth and nose, accumulated in lung and stomach, and stored in lung, spleen, and skin. Wei qi struggles with the toxin, and rubella is caused. Therefore, according to the invention, traditional Chinese medicine materials of franchet groundcherry calyx or fruit, Paris polyphylla smith, Asiatic moonseed rhizome, indigowoad leaf, common yam stem vine, puberulous glochidion branchlet and leaf, eriocarpous glochidion leaf, tree peony root-bark, redcalyx glorybower root, redroot gromwell, purslane speedwell herb, common ducksmeat herb, thorowort pondweed herb, skunk bugbane rhizome, and sawgrass root are decocted into a washing lotion by using water. As a results of clinical experiments of our hospital, after 3 days of treatment, rash subsiding rate and lymphadenopathy subsiding rate of a treated group are both higher than those of a control group. Side effect of fumigation is low, such that the fumigation lotion is suitable to be popularized.
BACKGROUND: Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of the Sustainable Intensification of Peritoneal Dialysis in Schleswig-Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate the presumed benefits of PD, including enhanced quality of life and reduced healthcare personnel requirements, and to generate data to strengthen the use of PD.
METHODS: The prospective SKIP-SH cohort study recruits patients with advanced chronic kidney disease (CKD) and their caregivers. Comprehensive data, including demographic information, medical history, clinical course, laboratory data, and quality-of-life assessments, are collected. Additionally, biomaterials will be obtained. Primary study objectives are documenting the clinical course and complications, time on therapy for new dialysis patients, reasons influencing treatment modality choices, circumstances at the initiation of dialysis, and quality of life for patients with CKD and their caregivers. The collected biomaterials will serve as a basis for further translational research. Secondary objectives include identifying factors impacting disease-related quality of life, clinical complications, and therapy dropout, estimating ecological footprints, and evaluating healthcare costs and labour time for initiating and sustaining PD treatment.
DISCUSSION: PD is notably underutilised in Germany. The current therapy approach for advanced CKD often lacks emphasis on patient-focused care and quality-of-life considerations. Furthermore, adequate explorative research programs to improve our knowledge of mechanisms leading to disease progression and therapy failure in PD patients are scarce. The overarching goal of the SKIP-SH cohort study is to address the notably low PD prevalence in Germany whilst advocating for a shift towards patient-focused care, quality-of-life considerations, and robust translational research.
TRIAL REGISTRATION: This study was registered with the German trial registry (Deutsches Register klinischer Studien) on November 7, 2023, under trial number DRKS00032983.
Interferon regulatory factor 1 (IRF-1) is a member of the IRF family. It is the first transcription factor to be identified that could bind to the interferon-stimulated response element (ISRE) on the target gene and displays crucial roles in the interferon-induced signals and pathways. IRF-1, as an important medium, has all of the advantages of full cell cycle regulation, cell death signaling transduction, and reinforcing immune surveillance, which are well documented. Current studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases, including but not limited to inhibiting the replication of the hepatitis virus (A/B/C/E), alleviating the progression of liver fibrosis, and aggravating hepatic ischemia-reperfusion injury (HIRI). The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients, which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer; additionally, the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease (AFLD/NAFLD), cholangiocarcinoma suppression, and uncommon traits in other liver diseases that had previously received little attention. Intriguingly, several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 signal. In this paper, we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.