anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Immunological disorder remains a great challenge in severe poly-trauma, in which lymphopenia is an important contributor. The purpose of present study is to explore whether ferroptosis, a new manner of programmed cell death (PCD), is involved in the lymphocyte depletion and predictive to the adverse prognosis of severe injuries.
PATIENTS AND METHODS: Severe polytrauma patients admitted from January 2022 to December 2022 in our trauma center were prospectively investigated. Peripheral blood samples were collected at admission (day 1), day 3 and day 7 from them. Included patients were classified based on whether they developed sepsis or not. Clinical outcomes, systematic inflammatory response, lymphocyte subpopulation, CD4 + T cell ferroptosis were collected, detected and analyzed.
RESULTS: Notable lymphopenia was observed on the first day after severe trauma and failed to normalize on the 7th day if patients were complicated with sepsis, in which CD4 + T cell was the subset of lymphocyte that depleted most pronouncedly. Lymphocyte loss was significantly correlated with the acute and biphasic systemic inflammatory response. Ferroptosis participated in the death of CD4 + T cells, potentially mediated by the downregulation of xCT-GSH-GPX4 pathway. CD4 + T cells ferroptosis had a conducive predicting value for the development of sepsis following severe trauma.
CONCLUSIONS: CD4 + T cells ferroptosis occurs early in the acute stage of severe polytrauma, which may become a promising biomarker and therapeutic target for post-traumatic sepsis.
At the beginning of stimulation, the current will be increased manually from 0.1 mA, in 0.1 mA increments over 60 seconds, up to a maximum of 1.8 mA. Participants will be instructed to notify study personnel if and when they feel any uncomfortable sensation. The ramp-up will be stopped at this point and for the remainder of the session tDCS will be delivered at an intensity of 0.1 mA below the highest level reached. At the end of each session, current will be automatically ramped down to 0.0 mA over a 60 second period.
A man in his 60s, known with multiple sclerosis, presented with seizures and paresis of the left arm and leg. Brain imaging showed a white matter lesion, right parietal, which was progressive over the last 6 years and not typical for multiple sclerosis. Brain biopsy showed a B-cell infiltrate with IgA lambda monotypic plasma cell differentiation and amyloid deposits, typed as lambda immunoglobulin light chain (AL). Bone marrow biopsy and PET/CT ruled out a systemic lymphoma. Extended history taking, blood and urine testing (including cardiac biomarkers) identified no evidence of systemic amyloidosis-induced organ dysfunction.Primary cerebral AL amyloidoma is a very rare entity where optimal treatment is difficult to assess. The patient was treated with locally applied volumetric modulated arc radiotherapy, 24 Gy, divided in 12 fractions. Afterwards, the paresis of the left arm partially resolved, and the function of the left leg improved. Seizures did not occur anymore.
Usual care is described as obstetrical care that pregnant women with normal BMI receive and that is provided by their provider. There will not be any antepartum education or 1-on-1 health coaching. Postpartum education will only include usual care in-hospital lactation support. There will not be any other education nor 1-on-1 support.
BACKGROUND: Periprosthetic joint infection (PJI) is a rare, yet devastating complication with high mortality rates, unpredictable treatment outcomes, and high costs. The purpose of this study was to determine 90-day and 1-year mortality rates at a specialized PJI center, assess the impact of delayed referral to a PJI center on outcomes, and determine the cost of PJI treatment prior to referral to a PJI center.
METHODS: A review of our institution's PJI registry was performed to identify patients who had a chronic PJI treated with a 2-stage exchange arthroplasty at our PJI Center from 2017 to 2021. Patients not referred from an external location were excluded. Mortality at 90 days and 1 year was collected. The date of infection diagnosis until the date of referral was recorded. Outcomes were documented as failure of treatment at the final clinical follow-up. The number and type of prior infection treatments were documented for each patient. The estimated cost was calculated using established PJI literature.
RESULTS: There were 172 patients (182 joints) who met inclusion criteria during this timeframe. The 90-day and 1-year mortality rates were 0 and 3.9%, respectively. There was a higher failure rate in patients referred >90 days after the diagnosis of chronic PJI (23 versus 11%, P = 0.031). The total cost of PJI treatment prior to referral for this group of patients was $6.9 million.
CONCLUSIONS: Implementation of a specialized PJI referral center leads to lower mortality rates, improved outcomes, and decreased cost for the health-care system.
Peri-menopausal discomfort can have a detrimental effect on the physical health of women due to physiological and behavioral changes. Estrogen and progesterone-based hormone therapy can alleviate menopausal symptoms, but estrogen supplementation may have negative health effects. The effectiveness of hormone replacement therapy using natural compounds for peri-menopausal disorders is still uncertain. Evidence from in vivo experiments indicates that Ferula L. extract in ovariectomized rats leads to better sexual behavior. The effect seems to be linked to the phytoestrogenic properties of ferutinin, the primary bioactive compound in the extract. The purpose of this study was to assess the clinical impact of Ferula communis L. extract (titrated at 20% ferutinin, and given at doses of 100 mg/die for 90 days) on the quality of life of 64 menopausal women. The clinical trial was randomized, double-blind, and placebo controlled. Our data showed that Ferula communis L. extract reduced by 67 + 9% all symptoms associated to postmenopausal discomfort and enhanced significantly sexual behavior. In addition, the supplement led to a significant improvement of BMI and oxidative stress decrease in the women who received it, while also keeping platelet aggregation within normal levels. Overall, these results could point to the potential use of supplementation with Ferula communis L. extract to revert or mitigate menopause dysfunction.
PROBLEM TO BE SOLVED: To obtain a detergent composition which has good foaming properties, rinsability, and finishing properties, has a viscosity suitable for the use, and is excellent in storage stability in a bottle by compounding an amphoteric surfactant, a hydrophilic nonionic surfactant, salts, and dibutylhydroxytoluene, by dispersing an oily component as particles, and by specifying the viscosity. SOLUTION: Based on the whole composition, the amphoteric surfactant is compounded in an amount of about 0.1-30 wt.%; and the hydrophilic nonionic surfactant is, in an amount of about 0.05-25 wt.%. Any inorganic or organic salt can be used, provided at least two salts are used, and the sum of amounts of salts compounded is preferably 0.05-5 wt.%. Preferably, dibutylhydroxytoluene is compounded in an amount of 0.0000001-1 wt.%. The oily component is a liquid or a solid, is dispersed as particles having an average particle size of 2 μm or lower, and is compounded preferably in an amount of 0.05-7 wt.%. The viscosity of the composition at a shear rate of 10 s-1 is 200-8,000 mPa.s/25 deg.C.
A method for modulation of an immune response utilizing chiral nanoparticles. The chiral nanoparticles can be synthesized from nanoparticle seed precursors using circularly polarized light. The chirality of the NPs can be measured using chirality measures such as the Osipov-Pickup-Dunmeur index, the Hausdorff chirality measure and by using circular dichroism spectra, g-factor spectra, and maximum g-factor for a specific wavelength. In- vivo tests in mice showed a 2.27-fold enhancement of immune cell maturation and 1584- fold enhancement of IgG production by L-nanoparticles versus D-nanoparticles. Both the in-vivo and in-vitro immune responses monotonically depend on the chirality, measured as g-factors, of the nanoparticles, indicating that nanoscale chirality of the nanoparticles can be used to regulate immune cell maturation. Finally, D-nanoparticles demonstrated 1258- fold higher efficiency as adjuvants for the H9N2 influenza virus versus D-nanoparticles or Alum, opening a path to utilization of nanoscale chirality in immunology.
The pharmaceutical formulations of the invention for masking the odor from the sulfur-containing active agent comprise at least one sulfur-containing active agent, an effective amount of at least one flavoring agent. Any flavoring agent or combinations of flavoring agents may be used in the pharmaceutical formulation of the invention. The flavoring agent may be natural flavors, natural fruit flavors, artificial flavors, and mixtures thereof. The pharmaceutical formulation may contain an artificial sweetener, a natural sweetener or mixtures thereof. The pharmaceutical formulations are provided in liquid dosage form or a dry powder dosage form for reconstitution in water. Stabilizer added as one of expicients can extend the stability of the pharmaceutical formulation liquid dosage form for a period of at least 30 days when the formulation is stored below room temperature. The pharmaceutical formulations of the invention are palatable and particularly useful for the administration of sulfur-containing drugs to very small children that are in need of such medications. Methods of forming a liquid dosage form of pharmaceutical formulation by adding water to the dry powder form, methods to prepare an odor-masking pharmaceutical formulation and methods for treating lead poisoning or Wilson's disease using the odor-masking pharmaceutical formulation are also provided.
Study data were collected prospectively and analyzed retrospectively. The demographic data of the patients, other parameters such as smoking, whether they sit a lot due to occupation (sitting at work for at least 6 hours a day), skin tone (whiter, darker), presence of positive family history, BMI (kg/m2, patients were divided into BMI \<30 and BMI\> 30), pilosity levels (mild,moderate, severe) were also recorded. In addition, the time from the recurrence to admission, the number and type of previous operations, and the status of the sinus at presentation (acute, chronic) were recorded. The presence of purulent discharge from the sinus opening and the presence of signs of inflammation or abscess formation in this region were evaluated as acute pilonidal sinus disease (PSD). The presence of serous discharge from the sinus opening and absence of abscess formation were evaluated as chronic PSD. Investigators investigated whether the factors mentioned above affect the number of applications and recurrence after crystallized phenol treatment (CPT).

The treatment procedure was applied to all patients by one surgical team. One day before the procedure, patients were asked to clean the hair from the waist to the middle of the thighs with depilatory creams or epilation. After local anesthesia was performed around the holes, a thin mosquito clamp was inserted into the sinus and the hairs were removed and the skin around the hole was covered by nitrofurantoin pomade to prevent chemical irritation. Then crystallized phenol was introduced into the sinus with the same clamp. Patients were allowed to return to their daily activities after the procedure. This procedure was performed every 3 weeks. If there was discharge from the wound during the follow-up examination, the procedure was repeated. The closure of the sinus hole and the complete disappearance of the discharge were accepted as healing. After the treatment, follow-up was started. Follow up was done first yearly than five years intervals. All of our patients' contact information was recorded by us and we tried to reach the patients every 5 years by any means (phone or e-mail). Investigators tried to follow them up by contacting them periodically, whether they contact us or not. According to this follow-up, patients were analyzed by divided into 3 groups(1-5 years, 5-10 years, 10-20 years). Patients who could not be reached by any means of communication were included in the unreachable group. Patients were recommended to have hair removal at the wound site once a month for 6 years.

Number of crystallized phenol application, presence of recurrence and number of recurrence after CPT and follow-up data were evaluated. Recurrence of the sinus hole which was found to occur again at least 6 months after being determined to be closed was considered as recurrence. If no recurrence was observed during the follow-up or if post-CPT recurrence was healed after treatment, CPT was considered successful.
Capsular units, each consisting of a cluster of individual capsules surrounded by an outer capsular wall and each capsule consisting of a substantially water-insoluble core surrounded by its own capsular wall, are prepared by dispersing discrete entities of the core material in an aqueous sol of a plurality of film-forming polymers having fractions of different molecular weights which are capable of undergoing coacervation under two sets of conditions, adjusting the condition of the sol-dispersion to one of the said sets of conditions to cause a part of the polymer materials to deposit as liquid walls around each of the core entities whilst the sol-dispersion is continuously agitated until clusters of the liquid walled entities form, thereafter changing the conditions to the second set of conditions to cause the remaining polymer material to deposit by coacervation around individual clusters and thereafter solidifying and optionally hardening the liquid wall materials around both the individual capsules and clusters thereof.  Specified film-forming materials are: gelatine, gum arabic, chondrus, zein, soya bean protein, polyethyleneimine, polyvinyl methyl ether-maleic anhydride and polyethylene-maleic anhydride copolymers.  Coacervation may be induced by the successive alteration of the pH of the aqueous sol to values within two suitable pH ranges or by the similar alteration of solubility conditions.  The core material may be a vegetable, animal, mineral or synthetic oil with or without additional dissolved or dispersed material or substantially water-insoluble solids.  By mixing dispersions in which different core materials have been formed into individual capsules and subsequently causing the second coacervation to occur, products containing a plurality of differing individual capsules within a single outer mantle may be formed.  A wide variety of materials which may be encapsulated are mentioned in addition to the above-mentioned oils, e.g. pharmaceuticals such as salicylamide, tetracycline hydrochloride and phosphate, phenaglycodol, cholorotrianisine, cholesterol, meprobamate, erythromycin propionate, benzathine penicillin G, Vitamins A-palmitate, B2 and K; flavours, aromatics and perfumes, e.g. cocoa-butter, coffee oil, musk, citronella, spearmint and palm oils; solids, e.g. magnetic iron oxide, calcium carbonate, zinc sulphide, carbon black, solid catalysts and polymer materials, bentonite and titanium dioxide.  Specification 751,600 is referred to.
Of the total number of subjects in clinical studies of remifentanil HCl, 486 were 65 and over (age range 66 to 90 years). While the effective biological half-life of remifentanil is unchanged, elderly patients have been shown to be twice as sensitive as the younger population to the pharmacodynamic effects of remifentanil. The recommended starting dose of remifentanil HCl should be decreased by 50% in patients over 65 years of age [see Clinical Pharmacology (12.3) and Dosage and Administration (2.2)]. Titrate the dosage of remifentanil HCl slowly in geriatric patients. [See Warnings and Precautions (5.4).]

The clearance of remifentanil is reduced (approximately 25%) in the elderly (> 65 years of age) compared to young adults (average 25 years of age). However, remifentanil blood concentrations fall as rapidly after termination of administration in the elderly as in young adults.
This is a multi-center, open-label, phase II, single-arm trial evaluating combination of darolutamide and high testosterone doses - extreme bipolar androgen therapy (ExBAT) - in patients with metastatic castration-resistant prostate cancer (mCRPC) progressing after abiraterone. Extreme androgen therapy will include alternating 56-day cycles of darolutamide 1,200mg/day (two 300 tablets every 12 hours) p.o. for 28 days followed by testosterone cypionate 400 mg i.m. During the treatment period, patients will be followed with chest, abdomen and pelvis CT and bone scan every 8-9 weeks until cycle 4 and every 12 weeks thereafter during the study period. Patients who present with disease progression but are considered to be benefiting from the treatment may continue receiving it, but will be followed by their treating physician according to local guidelines (follow-up period). All patients who stopped treatment will enter follow-up period and survival data will be collected from medical charts. Additionally, QoL questionnaires (BPI-SF, EQ-5D-3L and FACT-P) will be applied every 8-9 weeks until the end of treatment.
PURPOSE:To obtain hydraulic calcium phosphate cement not irritating a living body, hardening in a short time, having a great affinity for a living body and useful as medical cement, dental cement, etc., by using calcium quat. phosphate and calcium prim. phosphate as essential components. CONSTITUTION:Calcium quat. phosphate Ca4(PO4)2O of <=100 mesh, preferably <=325 mesh particle size is mixed with calcium prim. phosphate Ca(H2PO4)2 so as to satisfy 1.00-1.95 molar ratio of Ca to P and the resulting powdery mixture is used as a base and blended with a contrast medium such as barium sulfate or basic bismuth carbonate and an antimicrobial agent such as iodoform as required to obtain hydraulic calcium phosphate cement.
The invention provides a method, a device and a system for managing a medical crowd funding system, and relates to the technical field of data processing. Through the medical crowd-funding system provided by the embodiment of the application, the integration of a charitable information platform, a charitable institution and a hospital can be realized, and a complete medical aid solution is provided. The problem of difficult fund, the channel of raising money and the difficult problem of fund flow direction management that meet in national medical aid is solved. The system can provide an information publishing and donation platform for charitable institutions, hospitals and patients with the disease, and provide a data interface for communicating the hospitals and the charitable institutions, so that data sharing is achieved. The system can help the hospital information system to implement data docking, and can conveniently and directly transfer the good money to the hospital financial system. The main application program is optimized to remove the end very much, sweeps the sign indicating number and can accomplish the registration use, makes light financing, and the user experience of convenient donation effectively promotes the amount of financing and the speed of financing.
The correlation between novel negative pressure ureteroscopic lithotripsy (NP-URL) combined with flexible ureteroscopy (FU) and percutaneous nephrolithotomy (PCNL) on stone-free rates (SFR) remains unclear. There is a lack of evidence from Chinese populations regarding the relationship between SFR and NP-URL combined with FU (NP-URL-FU) versus PCNL. We aimed to assess the association between NP-URL-FU and PCNL on SFR. We conducted a cohort study involving 166 participants with 2-4 cm kidney stones. Data on SFR (7 days and 2 months) were collected from all participants. Logistic regression analysis was used to substantiate the research objectives. NP-URL-FU versus PCNL showed an 86% decrease in the 7-day SFR (OR = 0.14, 95% CI 0.07-0.29). The results remained stable even after adjusting for potential confounders. However, no statistically significant association was found between the surgical method and the 2-month SFR. Further exploratory subgroup analyses showed no significant interactions, with all P values > 0.05. Among patients with 2-4 cm kidney stones, NP-URL-FU was associated with a lower risk of incident 7-day SFR than PCNL. However, no statistically significant difference was found in the long-term stone removal rate. Therefore, NP-URL-FU may be a viable alternative surgical option for patients seeking minimally invasive procedures.
Early diagnosis of cerebral infarction, detection of ischemic penumbra, evaluation of collateral circulation and identification of vascular lesions by imaging are critical for treatment decision and outcome improvement in cerebral stroke. Multimodal computed tomography (CT) and magnetic resonance (MR) imaging are most prevalent and accessible approaches in clinical scenarios. These two approaches are downgraded either by radiation exposure or long scanning time which may hinder the rapid treatment for patients. Deep learning has shown substantial achievements in medical imaging enhancement. The added value of deep learning method in stroke and vascular neurology has not been thoroughly validated. In this study, we aimed to investigate the performance of enhanced computed tomography (CT) or magnetic resonance (MR) imaging by deep learning relative to conventional CT or MR imaging in brain stroke and vascular neurology. We expect that the deep enhanced imaging method can shorten the time stay in the imaging session of stroke patients, optimize the overall imaging quality and improve the patients' care in imaging session.
Hypertension affects a large number of individuals globally and is a common cause of nephropathy, stroke, ischaemic heart disease and other vascular diseases. While many anti-hypertensive medications are used safely and effectively in clinic practice, controlling hypertensive complications solely by reducing blood pressure (BP) can be challenging. α-Mangostin, a xanthone molecule extracted from the pericarp of Garcinia mangostana L., has shown various beneficial effects such as anti-tumor, anti-hyperuricemia, and anti-inflammatory properties. However, the effects of α-Mangostin on hypertension remain unknown. In this study, we observed that α-Mangostin significantly decreased systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR), possibly through the down-regulation of angiotensin II (Ang II). We also identified early markers of hypertensive nephropathy, including urinary N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG), which were reduced by α-Mangostin treatment. Mechanistic studies suggested that α-Mangostin may inhibit renal tubular epithelial-to-mesenchymal transformation (EMT) by down-regulating the TGF-β signaling pathway, thus potentially offering a new therapeutic approach for hypertension and hypertensive nephropathy.
A target analyte in a matrix is sensed using a sensor device having protrusions [ 500 ] such as e.g. nanorods, containing free charge carriers. Conformational molecules [ 504, 506 ] are bound at a first end to the protrusions, and bound at a second end to a label [ 502 ] e.g. a nanoparticle, that is free to move relative to the protrusions. The conformational molecule changes its conformation when bound to the analyte, thereby changing the distance and/or the relative orientation of the label to the protrusion. Energy [ 510 ] is used to excite free electrons in the protrusion near a plasmon resonance and resulting optical radiation [ 514 ] at wavelengths near the plasmon resonance wavelength is detected [ 516 ] and analyzed [ 518 ] to determined the presence/concentration of the analyte.