anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject essence having high safety and slight deterioration, useful as a medicine, a food, etc., at an appropriate cost by grinding Ginkgo biloba leaves and subjecting the ground Ginkgo biloba leaves to an operation such as an extraction with dimethyl ether, etc. SOLUTION: Ginkgo biloba leaves are ground, extracted by using hydrous dimethyl ether having 7-60% (W/W) water content for extraction in an amount of preferably 5-20 times as much as 1 pt.wt. (dry weight) of Ginkgo biloba leaves preferably at 10-30 deg.C. The extracted solution is separated from an extraction residue to recover an extraction filtrate. In order to precipitate a hydrophobic material from the extraction filtrate, dimethyl ether is evaporated and an aqueous extracted solution is obtained. A precipitate is formed, an aqueous extraction filtrate is separated from the precipitate, recovered and concentrated.  An electrolyte is added to the concentrated filtrate, an active ingredient is precipitated, an insoluble fraction is recovered, redissolved in hydrous dimethyl ether and desalted, insoluble substance is separated, the solvent is removed and a powdery essence is recovered by drying to give the objective essence.
FIELD: medicine, pharmaceutical technology. SUBSTANCE: invention relates to drugs prepared of vegetable raw. Proposed agent has ginseng root dried extract as an active component and accessory substances providing stability and resistance in storage. Agent can be made as different medicinal formulas: tablets, tablets with envelope, granules, granules in solid gelatin capsules. Agent shows enhanced adaptogenic effect as compared with that of ginseng root tincture and ginseng root powder tablets. EFFECT: enhanced activity of drug. 2 cl, 2 tbl, 2 ex
The Active Older Adults prospective cohort study examines the effects of a park-based fitness program on cardiovascular fitness outcomes for older adults (aged 50 years and older). Active Older Adults is designed to provide older adults of all fitness levels with physical activity, and aims to promote participant's abilities to maintain independent lifestyles. It is a low-cost, evidence-based group exercise and falls-prevention program. The program entails one-hour sessions two or three times per week including aerobic workout, strength training, balance and flexibility exercise delivered online or in-person. Data are collected at eight Miami Dade Department of Parks, Recreation and Open Spaces (MDPROS) park locations where the program is offered every four months (fall, winter, spring).

Active Older Adults is a park-based fitness program offered by the Miami Dade Department of Parks, Recreation and Open Spaces (MDPROS) that is designed to provide older adults of all fitness levels with physical activity, and aims to promote participant's abilities to maintain independent lifestyles. It is a low-cost, evidence-based group exercise and falls-prevention program. The program entails one-hour sessions two or three times per week including aerobic workout, strength training, balance and flexibility exercise delivered online or in-person. Exercise classes at each park location are offered by bilingual (English/Spanish) licensed instructors and program classes had a consistent format across all parks.
The invention provides a traditional Chinese medicine formula for tonifying qi and nourishing blood, a preparation method and application thereof, and a medicated diet for tonifying qi and nourishing blood and a preparation method thereof, and relates to the technical field of medicines. A traditional Chinese medicine formula for benefiting qi and nourishing blood comprises the following components in parts by weight: 5-10 parts of ginseng, 5-15 parts of bighead atractylodes rhizome, 5-20 parts of monkshood, 5-15 parts of poria cocos, 5-10 parts of honey-fried licorice root, 5-20 parts of prepared rehmannia root, 5-15 parts of Chinese angelica, 5-15 parts of white paeony root, 5-15 parts of ligusticum wallichii and 5-8 parts of pseudo-ginseng. Has the efficacy of benefiting qi and nourishing blood, is safe and effective and has obvious curative effect. The preparation method of the traditional Chinese medicine formula for benefiting qi and nourishing blood comprises the following steps: drying the raw materials, pulverizing, and mixing. The preparation method is simple and easy to implement, has strong operability, retains the drug effect to the maximum extent, and is easy for industrial production. The medicated diet for benefiting qi and nourishing blood has the characteristics of safe, effective, economical and feasible application and is easily accepted by patients.
PURPOSE:To provide an ester which is useful as a base for a sustained release preparation, etc. CONSTITUTION:An ester at the terminal carboxyl group of a linear polyester made from an alpha-hydroxymonocarboxylic acid and having a wt. average mol.wt. of about 1,500-50,000 is provided. This ester is usable as a base of a sustained release preparation. The base is stable to light, heat, moisture, coloration and hardly toxic. A sustained release preparation produced using the ester exhibits a constant release of a drug for a long term and provides long-lasting stable effects. Moreover, an excessive release of a drug hardly occurs just after the dosing of the preparation.
BACKGROUND: Iran is facing an epidemiological transition with the increasing burden of non-communicable diseases, such as obesity-related disorders and cardiovascular diseases (CVDs). We conducted a population-based prospective study to assess the prevalence and incidence rates of CVDs and obesity-related metabolic disorders and to evaluate the predictive ability of various CVD risk assessment tools in an Iranian population.
METHOD: We enrolled 5,799 participants in Amol, a city in northern Iran, in 2009-2010 and carried out the first repeated measurement (RM) after seven years (2016-2017). For all participants, demographic, anthropometric, laboratory, hepatobiliary imaging, and electrocardiography data have been collected in the enrollment and the RM. After enrollment, all participants have been and will be followed up annually for 20 years, both actively and passively.
RESULTS: We adopted a multidisciplinary approach to overcome barriers to participation and achieved a 7-year follow-up success rate of 93.0% with an active follow-up of 5,394 participants aged 18-90 years. In the RM, about 64.0% of men and 81.2% of women were obese or overweight. In 2017, about 16.2% and 5.2% of men had moderate or severe non-alcoholic fatty liver disease, while women had a significantly higher prevalence of metabolic syndrome (35.9%), and type 2 diabetes mellitus (20.9%) than men. Of 160 deceased participants, 69 cases (43.1%) died due to CVDs over seven years.
CONCLUSION: The most prevalent obesity-related chronic disease in the study was metabolic syndrome. Across the enrollment and RM phases, women exhibited a higher prevalence of obesity-related metabolic disorders. Focusing on obesity-related metabolic disorders in a population not represented previously and a multidisciplinary approach for enrolling and following up were the strengths of this study. The study outcomes offer an evidence base for future research and inform policies regarding non-communicable diseases in northern Iran.
OBJECTIVE: Breast cancer is one of the leading cancer causes among women worldwide. It can be classified as invasive ductal carcinoma (IDC) or metastatic cancer. Early detection of breast cancer is challenging due to the lack of early warning signs. Generally, a mammogram is recommended by specialists for screening. Existing approaches are not accurate enough for real-time diagnostic applications and thus require better and smarter cancer diagnostic approaches. This study aims to develop a customized machine-learning framework that will give more accurate predictions for IDC and metastasis cancer classification.
METHODS: This work proposes a convolutional neural network (CNN) model for classifying IDC and metastatic breast cancer. The study utilized a large-scale dataset of microscopic histopathological images to automatically perceive a hierarchical manner of learning and understanding.
RESULTS: It is evident that using machine learning techniques significantly (15%-25%) boost the effectiveness of determining cancer vulnerability, malignancy, and demise. The results demonstrate an excellent performance ensuring an average of 95% accuracy in classifying metastatic cells against benign ones and 89% accuracy was obtained in terms of detecting IDC.
CONCLUSIONS: The results suggest that the proposed model improves classification accuracy. Therefore, it could be applied effectively in classifying IDC and metastatic cancer in comparison to other state-of-the-art models.
BACKGROUND: Despite improvement in treatment strategies for atrial fibrillation (AF), a significant proportion of patients still experience recurrence after ablation. This study aims to propose a novel algorithm based on Transformer using surface electrocardiogram (ECG) signals and clinical features can predict AF recurrence.
METHODS: Between October 2018 to December 2021, patients who underwent index radiofrequency ablation for AF with at least one standard 10-second surface ECG during sinus rhythm were enrolled. An end-to-end deep learning framework based on Transformer and a fusion module was used to predict AF recurrence using ECG and clinical features. Model performance was evaluated using areas under the receiver operating characteristic curve (AUROC), sensitivity, specificity, accuracy and F1-score.
RESULTS: A total of 920 patients (median age 61 [IQR 14] years, 66.3% male) were included. After a median follow-up of 24 months, 253 patients (27.5%) experienced AF recurrence. A single deep learning enabled ECG signals identified AF recurrence with an AUROC of 0.769, sensitivity of 75.5%, specificity of 61.1%, F1 score of 55.6% and overall accuracy of 65.2%. Combining ECG signals and clinical features increased the AUROC to 0.899, sensitivity to 81.1%, specificity to 81.7%, F1 score to 71.7%, and overall accuracy to 81.5%.
CONCLUSIONS: The Transformer algorithm demonstrated excellent performance in predicting AF recurrence. Integrating ECG and clinical features enhanced the models' performance and may help identify patients at low risk for AF recurrence after index ablation.
Chloroform or trichloromethane is one of the trihalomethanes formed during disinfection of water with chlorine, and residues of chloroform can be detected in foods and food products due to the use of chlorinated drinking water and disinfecting food processing equipment with chlorine-based disinfectants. In this study, chloroform was detected in 37 (or 23%) of the 159 composite food samples from the 2014 Canadian Total Diet Study, but was not detected in cereals, fruits, fast foods, and most of the meat samples. Chloroform was detected in almost all 14 composite samples of dairy products, with the highest level (58 ng/g) observed in butter, followed by cream (26 ng/g), and cheese (12-21 ng/g). Chloroform was detected in tap water (23 and 29 ng/g) and most of the beverage samples, but concentrations were lower than those reported in other studies possibly due to evaporation during the preparation of the composite samples. Dietary exposures to chloroform are higher for younger age groups (0.51-1.41 µg/kg body weight/day) than for adults (0.25-0.42 µg/kg body weight/day). Drinking water contributed most to daily intakes for all age groups, accounting for between 62% and 86% of the total chloroform dietary intakes.
INTRODUCTION: In previous studies on thyroid hormones and frailty, most of the target population were elderly, and there were relatively few studies on elderly patients with coronary heart disease (CHD). Inflammation, oxidative stress, and haemodynamic instability in cardiovascular disease (CVD) can influence fluctuations in thyroid hormone (TH) levels and increase the incidence of frailty. The purpose of the present study was to explore the effect of TH on the risk of frailty in elderly patients with CHD.
MATERIAL AND METHODS: The Fried scale was used to assess the frailty of participants. The predictive value of TH for frailty was determined using the patient's operating characteristic curve. Multivariate logistic regression model was utilised to analyse the relationship between TH and frailty.
RESULTS: A total of 277 elderly patients with CHD were included in the study, of whom 29.96% were in a state of frailty. Free triiodothyronine (FT3)/free thyroxine (FT4) predicted frailty with the largest area under the curve of 0.634. Unordered multinomial logistic regression analysis showed that a lower T3 level was a risk factor for pre-frailty (p < 0.05). Lower levels of T3, FT3, and FT3/FT4 were risk factors for frailty (p < 0.05) after adjusting for demographic variables and blood indexes.
CONCLUSION: The predictive value of FT3/FT4 for frailty was more accurate than that of a single index. Moreover, T3 ≤ 1.095 nmol/L, FT3 ≤ 4.085 pmol/L, and FT3/FT4 ≤ 0.336 were shown to be the influencing factors of frailty, while T3 ≤ 1.095 nmol/L is an independent risk factor pre-frailty. Clinicians should focus on timely identification of the risk of frailty in order to improve patient quality of life and to reduce the risk of complications.
In pediatric dentistry, preventive dental approaches are essential in providing sustainable oral health of children. Despite all the preventive applications, dental caries is still an important public health problem affecting preschool and school children. Oral hygiene education has an important role on the dental health services. This aims to increase awareness of oral health, provide information about it and encourage individuals to maintain oral health. Based on, the current study aims to evaluate the effects of verbal and video-based oral hygiene instructions on the oral health parameters in patients of different age groups. 202 patients in 6-9 and 10-12 aged (n=101 and n=101, respectively) were included in the study protocol. Before oral hygiene instructions, baseline oral g of all patients were determined using Simplified Oral Hygiene Index (OHI-S). Within each age group, approximately half of the participants randomly assigned to verbal (n=50 for 6-9 ages, n=51 for 10-12 ages) and video-based OHI (n=51 for 6-9 ages, n=50 for 10-12 ages). Patients were re-called for after 30 days and final OHI-S scores were recorded. Data were analysed with Shapiro-Wilk, Mann-Whitney U and Wilcoxon Signed Rank tests. Statistical significance level was considered as 5%.
The efficacy of tranexamic acid in the treatment of heavy menstrual bleeding (HMB) in women of reproductive potential was demonstrated in two randomized, double-blind, placebo-controlled studies: one 3-cycle treatment study (Study 1) and one 6-cycle treatment study (Study 2) [see Adverse Reactions (6.1)]. In these studies, HMB was defined as an average menstrual blood loss of ≥ 80 mL as assessed by alkaline hematin analysis of collected sanitary products over two baseline menstrual cycles. Subjects were 18 to 49 years of age with a mean age of approximately 40 years, had cyclic menses every 21-35 days, and a BMI of approximately 32 kg/m2. On average, subjects had an HMB history of approximately 10 years and 40% had fibroids as determined by transvaginal ultrasound. Approximately 70% were Caucasian, 25% were Black, and 5% were Asian, Native American, Pacific Islander, or Other. Seven percent (7%) of all subjects were of Hispanic origin.

In these studies, the primary outcome measure was menstrual blood loss (MBL), measured using the alkaline hematin method. The endpoint was change from baseline in MBL, calculated by subtracting the mean MBL during treatment from the mean pretreatment MBL. The key secondary outcome measures were based on specific questions concerning limitations in social or leisure activities (LSLA) and limitations in physical activities (LPA). Large stains (soiling beyond the undergarment) were also included as a key secondary outcome measure.
PROBLEM TO BE SOLVED: To provide a composition containing ketotifen or a salt thereof stabilized at a high level even in an aqueous solution. SOLUTION: The stability of the ketotifen or the salt thereof to the light is improved by adding 0.01-100,000 pts.wt. xanthines (caffeine, theophylline or the like) based on 1 pts.wt. ketotifen or the salt thereof. The composition is useful as an aqueous composition, e.g. a topically applied composition such as an eye drop, and a composition applied to the mucous membrane.
PURPOSE: To certainly remove a toxicity and prevent a parallel propagation of pollution by comprising the dosing device of dosing a specified dosage by means of a jet connected to the supply means of a vaccinal composition with a predetermined concentration. CONSTITUTION: In a dosing device 1, a rechargeable means 23 is arranged between an electrical motor 2 and a cum 4. In the stop position, a piston 7 is pushed by the bias of a returning spring 6 and then a constant amount of a liquid is charged into a discharging head 11. When the liquid is going to be discharged, a rod 5 is driven by the cum 4 by acting against the bias of the returning spring 6. When the piston 7 is driven toward a nozzle 12 by the rod 5, the constant amount of the liquid is discharged under a superhigh pressure. Further, the rod 5 is released when the cum 4 is rotated, and returned to an original position by the bias of the returning spring 6. At the same time, the piston 7 is also returned so that the liquid is sucked into the discharging head 11 through a sliding valve 7'.  At that time, a valve 19 is moved to a closing position in a supporting body 20 so as to be able to suck an adequate quantity of the liquid. According to the structure of the discharging means and the dosing means, the dosage of 0.3ml may be possible.
A dermatological agent is disclosed for aiding the transport of oxygen in the skin, as well as a process for preparing the same and its use. The problem with the known dermatological agents is the insufficient oxygen supply to the skin and adjacent tissues. The object of the invention is thus to overcome the stratum corneum of the skin and the epiderm by penetration processes in order to increase the oxygen concentration in the corial zone and adjacent tissues and to activate the metabolic processes. For that purpose, a dermatological agent with asymmetrical lamellary aggregates consists of phospholipids and oxygen-loaded fluorocarbon or a fluorocarbon mixture. The proportion of fluorocarbon lies in a range from 0.2 to 100 % by weight/volume, in an excipient appropriate for dermatological uses. This dermatological agent is prepared by emulsifying its components and by using it in salves, creams, lotions, liquids, alcoholic extracts, pastes, powders, gels, tinctures or on plasters and bandages, or in a spray.
The lead has a core with a powder-like, soft consistency. It is surrounded by a shell that is hard and strong in comparison. It also rubs off when applying the cosmetic. The shell is lipophile or hydrophile and the core is the opposite; hydrophile or lipophile. The melting points of the two materials for core and shell differ by at least five degree Celsius. The lead is produced using coextrusion. The soft core and the hard shell are extruded at the same time. A metal insert is placed in the mould. The shell is poured around the insert. This is then removed and the core is cast. The core is then heated to harden it.
The control group had no educational interaction with the researcher after the pre-test. The control group was administered the one-week and three-month posttest THLS-32 by the researcher simultaneously with the intervention group.
Participants will be asked to follow a TRE meal pattern for 14 consecutive days. Participants will be encouraged to consume food and beverages only within a 10-h time window for the 14-day intervention, with the exception of water, which will be encouraged at any time.
Participants will receive an oral solution of JNJ-70075200 or placebo in single ascending doses on Day 1 in cohorts 1, 2, 3, 4, 5a and 6 under fasted condition. Participants in cohort 5a will additionally receive the same study intervention under fed condition (Cohort 5b) after a washout period of at least 7 days.
A system for controlling the operations of a computerized device requires a sequence of two-way communications between a user and a computer. These communications both validate and control the operation of the device. A first communication from the user to the computer provides instructions that typically include changes for an operation of the device. In response, the computer requests user validation and identification. A second communication from the computer to the user then provides an operational status report of the system and a request for operational confirmation from the user, together with revalidation of user identification. An operation of the communication system is accomplished by selectively using audio, visual, and tactile signals from the user, interactively with vibrations, light variations, visual presentations and sound sequences from the device.
A powder-based lip liner cosmetic composition comprises: (1) a talc component; (2) a mica component; (3) a low luster pigment; (4) a substantially hydrophobic polymer; (5) an at least partially hydrophilic polymer; and (6) an emulsifier component. Preferably, the talc component includes talc coated with an aluminum salt of a long-chain fatty acid. Preferably, the mica component includes mica coated with an aluminum salt of a long-chain fatty acid. Preferably, the low luster pigment includes mica, titanium dioxide, and barium sulfate. Preferably, the cosmetic composition further comprises a skin-tone-dependent pigment, as well as ancillary components. The lip liner cosmetic composition of the present invention provides a long lasting lip line resistant to contact with surfaces and eliminates the problem of "bleeding" or "feathering" of lipstick into the lip liner. This is achieved by the insolubility of lipstick in the lip liner because of the low wax and oil content of the lip liner of the present invention. The lip liner of the present invention is preferably applied by the use of a water-wetted brush, unlike any other lip liners previously available.
Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid molecule of the disease-causing microorganism is delivered to the animal. In another embodiment, the RNA or nucleic acid molecule is delivered to the animal by replicon particle. In a further embodiment, the protective molecule is delivered to the digestive tract of the animal. Protection from disease is obtained.
Subjects in the control group will receive a one-time 1 ml of 0.9% injectable normal saline prior to the start of the ureteroscopic procedure. After consent and during screening visit demographic information, medical/surgical history, and height and weight will be collected. On Day 0 subject will be randomized to NSAID or Saline using inclusion/exclusion criteria and the procedure data will be collected. On Day 1 subject will receive a follow up phone call and complete AUA Symptom Score, USS Questionnaire 1 and USS Questionnaire 2 and any adverse events will be assessed. These questionnaires will again be administered on the day of stent removal and again 1 to 2 months post stent removal.