anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Prevalence of unexpected positive intraoperative cultures (UPIC) in revision total knee arthroplasty (TKA) is reported to be 8.32% with largely varying findings in individual studies (5.92-62.07%) due to a heterogeneity in preoperative diagnostic work-up and diagnostic criteria for periprosthetic joint infection (PJI). When diagnosed as unsuspected PJI, re-revision rate is reported to be as high as 18.45% compared to 2.94% in patients with UPIC classified as contamination (p = 0.0237). We performed a monocentric retrospective analysis of revision TKA surgery to determine prevalence of UPIC, risk of developing a subsequent PJI and re-revision rate after 24 months compared to those without UPIC.
MATERIALS AND METHODS: All presumed aseptic total knee revision procedures from 2008 until 2017 were retrospectively reviewed. Single stage femorotibial revisions of TKA with at least 3 intraoperative cultures and a minimum follow-up of 24 months were included, whereas partial revisions or revisions from unicompartimental knee prosthesis to TKA were excluded. Demographic data were collected as well as initial reason for revision, preoperative aspiration results, micro-organism identified and postoperative antibiotics' administration. Primary outcome was survival rate after 24 months with differentiation based on UPIC interpretation: sterile, contamination, unsuspected PJI.
RESULTS: Of 256 included cases, 75 (29.3%) were found to have at least 1 UPIC during revision surgery, 72% of whom a single UPIC was found. Thirty-four cases (13.28%) were interpreted as unsuspected PJI and therefore treated with antibiotics. In total, 13 of the 256 patients (5.08%) had to be re-revised during follow-up with 7 PJI (2.73%), none of them developing reinfection defined as PJI with the same microorganism. A statistically significant trend towards earlier failure in the unsuspected PJI group compared to the contaminant group was not observed. However, a higher incidence of re-revisions attributed to septic reasons was noted in the former group.
CONCLUSIONS: Presence of UPIC in presumed aseptic revision TKA does not correlate with a lower survival rate, but a higher incidence of subsequent PJI was observed in cases interpreted as unsuspected PJI.
Three to 4 weeks after the procedure the patient will undergo a limited CT scan of the pelvis to visualise the position of the SNS lead. The scan will focus only on the sacrum, implanted lead, and rectum and will not be extended beyond this area. Imaging from this CT will be superimposed to the MRI imaging the patient had pre-operatively, and a computational simulation will be performed.
Severe acute exacerbation of hepatitis has been reported in patients who have discontinued anti-hepatitis B therapy, including therapy with HEPSERA. Hepatic function should be monitored at repeated intervals with both clinical and laboratory follow-up for at least several months in patients who discontinue HEPSERA. If appropriate, resumption of anti-hepatitis B therapy may be warranted.

In clinical trials of HEPSERA, exacerbations of hepatitis (ALT elevations 10 times the upper limit of normal or greater) occurred in up to 25% of patients after discontinuation of HEPSERA. These events were identified in studies GS-98-437 and GS-98-438 (N=492). Most of these events occurred within 12 weeks of drug discontinuation. These exacerbations generally occurred in the absence of HBeAg seroconversion, and presented as serum ALT elevations in addition to re-emergence of viral replication. In the HBeAg-positive and HBeAg-negative studies in patients with compensated liver function, the exacerbations were not generally accompanied by hepatic decompensation. However, patients with advanced liver disease or cirrhosis may be at higher risk for hepatic decompensation. Although most events appear to have been self-limited or resolved with re-initiation of treatment, severe hepatitis exacerbations, including fatalities, have been reported. Therefore, patients should be closely monitored after stopping treatment.
The present invention belongs to field of pharmaceutical preparation, and relates to an anti-cancer medicine liposome preparation which is sensitive to beam. According to the invention, the liposome preparation is prepared through enveloping the active compound comprising the anti-cancer medicine with lipid. The medicine is released under the function of beam. The preparation can concentrate the tumor chemotherapy and radio-therapeutic sensitivity intensifier which have radio-therapeutic sensitivity intensifying effect to the tumor position, and releases the tumor chemotherapy and radio-therapeutic sensitivity intensifier from the liposome for exerting the curative effect. The preparation increases the effective concentration of tumor chemotherapy and radio-therapeutic sensitivity intensifier which have radio-therapeutic sensitivity intensifying effect at the focus position and the staying time in vivo and the efficiency of entering the infected cell, thereby increasing the anti-tumor effect of medicine, reducing the medicine taking dose and medicine toxicity and prolonging the life duration of tumor patient. The preparation of the invention can be used for treating various tumors.
Dyslexia is described as a learning disability with a neurological origin. It is a widespread disease, characterized by difficulties in recognition of words, spelling, and decoding. It is an unexpected and permanent failure in gaining reading skills in the individual who have sufficient intelligence, socio-cultural opportunities, and education, according to the World Health Organization. The diagnosis can be made by a child and adolescent psychiatrist clinically or with the Diagnostics and Statistical Manual of mental disorders (DSM-5). The prevalence of dyslexia varies between 2-10%, and it is seen 3-4 times more in men than in women.

Postural balance is the ability to control the center of gravity (CoG) on the support base. This control starts to appear at the beginning of the 15th months of life and reaches its maximum capacity at around 12 years with the maturation of visual, vestibular, and somatosensory systems. Static balance defines the postural control state in the maintaining position, while dynamic balance represents it during movement. Static and dynamic balance has been widely investigated and found to be impaired in different pediatric disorders such as cystic fibrosis, cerebral palsy, and spina bifida. There is also apparent evidence of deteriorated balance in children with dyslexia. Frankle and Levinson suggested that there is a cerebellar-vestibular disorder in people with dyslexia for the first time in 1973. They found that 97% of 115 children with dyslexia abnormal neurological findings such as positive Romberg test, walking difficulty, speech disorder, or hypotonia. After then, Rae et al. reported that the right frontal lobe of the cerebellum was smaller, and there were distinct biochemical changes on the temporoparietal lobe in dyslexic individuals compared to healthy controls. Moe-Nilssen et al. showed that dyslexic children have impairment in both balance and gait ability. Barela et al. claimed that writing and learning disorders in dyslexia were associated with cerebellum. Patel et al. found that postural instability was related to the severity of dyslexia. Quercia et al. gave postural exercise treatment to the dyslexics, then examined their postural stability after a vibrational stimulation. The length and speed of CoG were shown to be significantly higher in untreated dyslexic patients compared to the treated dyslexics and the non-dyslexic group.

Although quite a number of studies investigated balance impairment in individuals with dyslexia, only one study was interested in the effects of a postural training program and found significant improvements. That study addressed such improvements to brain plasticity, however, did not investigate the reading performance simultaneously. The aim of this study was to demonstrate the changes in static and dynamic balance, reading performance, and quality of life after a six week after a scheduled exercise program in children with dyslexia.
Rheumatoid arthritis (RA) is the most common chronic inflammatory arthropathy and it mostly affect young women. The MRI sequences currently validated for the joint inflammation assessment are the fat-suppressed sequences produced either by spectral presaturation (CHESS sequences) or by inversion-recovery (STIR = short tau inversion recovery sequence). The presaturation sequences outweigh the STIR sequence due to higher spatial resolution at the expense of sometimes more random saturation of the fat signal. Recently, a third method of suppressing the fat signal (Dixon method) has reappeared thanks to advances in computing power (post-processing). In a preliminary MRI study of the hands of healthy volunteers, the investigators showed that the suppression of the fat signal obtained by the Dixon sequences is greater than that obtained by the "classic" CHESS sequences in T1 and T2 weighting with better quality. image in T1 weighting. This increased performance, particularly in terms of fat suppression, could lead to better detection of PR lesions on MRI.
After induction of general anesthesia, patients will be positioned in the lateral position . A linear ultrasound transducer will be placed on the midline to identify the T8 spinous process. From this position, the ultrasound transducer was moved 2-3 cm laterally to visualize the hyperechoic line of the T8 transverse process with its associated acoustic shadow inferiorly, and the overlying erector spinae muscle superiorly. 30 ml 0.25% bupivacaine will be injected.
* LEQVIO should be administered by a healthcare professional.
  * Inject LEQVIO subcutaneously into the abdomen, upper arm, or thigh. Do not inject in areas of active skin disease or injury, such as sunburns, skin rashes, inflammation, or skin infections.
  * Inspect LEQVIO visually before use. It should appear clear and colorless to pale yellow. Do not use if particulate matter or discoloration is seen.



For more detailed instruction on administration of the prefilled syringe, see Instructions for Use.
The invention relates to a traditional Chinese medicine composite suppository for treating constipation, prepared by the following raw materials by weight parts: fructus cannabis 5-55 parts, sesame 1-50 parts, peach kernel 5-40 parts, schizonepeta spike 10-60 parts. The fructus cannabis, sesame and peach kernel are mixed and pressed to produce oil, and then the produced oil is washed using hot water until no floc in the produced oil and then the produced oil is filtered for standby; the schizonepeta spike is subjected to wet distillation and the oil layer is separated and extracted and then mixed with the above produced oil and then the ground substance is added into the mixture to produce suppository and finally the traditional Chinese medicine composite suppository is subjected to thermal sealing and packaging. The traditional Chinese medicine composite suppository has obvious curative effect, based on 'syndrome differentiation and treatment' principle of traditional Chinese medicine syndrome. The long time clinical practice shows that: the traditional Chinese medicine composite suppository has stable curative effect on constipation due to blood-deficiency and body-fluid little. The traditional Chinese medicine composite suppository not only relieves symptom but also radically treats the constipation. The traditional Chinese medicine composite suppository is mainly used for treating stool constipation due to oldness and debility, blood-deficiency and body-fluid little after serious illness and delivery. The traditional Chinese medicine composite suppository does not comprises any western medicine with low side effect and conquers the defects of western medicine of large side effect and higher cost, namely an economic medicine with definite curative effect.
Crossed cerebellar diaschisis (CCD) is a phenomenon of functional diaschisis that occurs after damage to the cerebral hemisphere and results in decreased activity of the cerebellum outside the primary focus. In this case report, we present the case of a patient admitted for seizures who was diagnosed with CCD due to Mesial temporal sclerosis (MTS). This event is generally observed in ischemic stroke cases and can occur epileptic seizure disorders. However, association of CCD with MTS is very rare. This article provides a comprehensive overview of CCD and related MRI findings to better understand their pathophysiology, clinical implications, and potential therapeutic approaches. The article highlights the importance of MRI in CCD detection and monitoring and discusses its usefulness in different clinical scenarios.
Irritability, defined as a predisposition to exhibit anger, is a prominent, defining symptom of perinatal depression (PND) and many other neuropsychiatric disorders. Despite the near ubiquity of irritability across disorders, the neural dysfunction underlying the vulnerability to, onset of, and exacerbation of irritability is understudied and poorly understood. The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period. This endocrine manipulation paradigm, which the investigators have shown provokes irritability in past studies, will be used to examine the neurocircuitry underlying irritability under baseline and hormone challenge conditions among women who are hormone sensitive (HS+; n=15) and non-hormone sensitive (HS-; n=15). The long-term goal of this research is to advance understanding of the neural systems underlying both the triggering of and susceptibility to irritability in women. The objective of the current project is to examine whether HS+ show differences in the behavioral activation system relative to HS- under baseline and hormone challenge conditions using functional magnetic resonance imaging (fMRI) and behavioral tests. The investigator's central hypothesis is that reproductive hormone changes are associated with dysregulated threat and reward processing and consequent irritability in HS+. The rationale for the proposed study is that employing a scaled down model of puerperal hormonal events permits the identification of a group of individuals homogeneous for hormone sensitivity (HS+), hence creating the best opportunity for disentangling the specific changes in brain function due to reproductive hormones (i.e., HS-) from those accompanying reproductive hormone-precipitated affective dysfunction (i.e., HS+). Because women will act as their own controls across time, this study design also allows for a powerful evaluation of state and trait variables that may contribute to irritability, including both threat and reward processing. Identifying both state and trait markers of irritability, and disentangling them from the effects of reproductive hormones on brain and behavior, will allow for the identification of neural substrates of irritability susceptibility that can be investigated across neuropsychiatric disorders. The expected outcome of this research is the identification of neural circuits underlying both the susceptibility to and mediation of irritability.
The invention provides a Songqing anti-inflammation capsule. The Songqing anti-inflammation capsule is a common name of a medicament and has a name in pinyin of songqingyanjiaonang. The capsule comprises the following components in weight proportion: 10g of bulbus fritillariae cirrhosae, 10g of indigo, 12g of borneol, 10g of liquorice, 10g of borax, and 10g of calamitas urinae hominis. The capsule is characterized in that: the medicament is a capsule in blue powder shape, and has cool feeling. The preparation method of the capsule comprises the following steps: respectively grinding the components into fine powder; mixing and grinding uniformly; and filling into capsules for later use. The anti-inflammation capsule has the functions of clearing damp heat, resisting bacteria, diminishing inflammation and relieving pains, and is used for treating vaginitis, pruritus of vagina, monilial or mycotic vaginitis, chronic cervicitis, cervical erosion, lumbago and abdominal distension, cervical cancer, ulcer, AIDS (acquired immure deficiency syndrome) virus and male priapitis and erosion, and can prevent sexual virus infection by spreading little medicament to balanus in sexual intercourse between male and female. The specification is that: each capsule is filled with 0.25g of medicament. Dosage is that: 2 capsules are taken orally each time and 3 times a day, and are taken with boiled water; the dosage is reduced for children according to the circumstance or medical advice; and the capsule should be dosed appropriately for external use.
The invention provides a medicine for treating skin diseases. The medicine is processed by taking the whole plant of Broussonetia kaempferi Sieb. or the fruits of Broussonetia kaempferi Sieb. as the main raw material. According to the medicine, the medicinal Broussonetia kaempferi Sieb. is taken as the main raw material of the medicine for treating skin diseases, and thus the use safety of the medicine is guaranteed. For the medicine obtained by processing the whole plant of Broussonetia kaempferi Sieb. or the fruits of Broussonetia kaempferi Sieb., the preparation method is simple, the cost is low, and the medicine has good curative effects for skin pigmentation and seborrheic subcutaneous fat oncoma.
The purpose of the New Moves study is to evaluate the effectiveness of a school-based all girls alternative to regular physical education class for inactive high school girls. New Moves uses a large-scale community randomized controlled study involving girls from six intervention schools and six control schools. The New Moves class includes physical activity, nutritional guidance, and social support within a supportive, non-competitive environment. In addition the program includes individual counseling sessions.

The primary research hypothesis is that girls in the intervention condition will significantly decrease their percent body fat as compared to girls in the control condition. Secondary research hypothesis to be tested are that girls in the intervention condition will significantly increase their level of physical activity and improve the quality of their dietary intake as compared to girls in the control condition. In addition a range of socioenvironmental, personal, and behavioral variables will be compared across conditions.
Patients allocated to the counseling group (Group I) were informed about possible etiological factors and educated to not overload the temporomandibular joint and masticatory muscles. Techniques to relieve pain and tension were taught to correct postural habits, food and sleep irregularities. The patients received written instructions, as a way of reinforcing the information provided during the initial consultation. In subsequent returns at 7, 15, 30 and 60 days of follow-up, the instructions were given again and patients were asked whether they had detected any habits related to the initiation and maintenance of painful symptoms of TMD, as a way to further highlight the association between the presence of these harmful behaviors and the worsening signs and symptoms of TMD.
The use of a noble gas (I), selected from argon, xenon, krypton, helium, neon and their mixtures, is claimed in (or in the production of medicaments for) the prophylaxis or therapy of inner ear diseases. Independent claims are included for: (1) (I)-containing medicaments for use as above; and (2) a corresponding prophylaxis or therapy method. ACTIVITY : Auditory. The effect of argon against cisplatin (CP)-induced damage to the external and internal hair cells in new-born rat organ cultures was determined. The organ fragment culture from one ear was incubated under a mixture of 95% air and 5% carbon dioxide and that from the contralateral ear was incubated under a mixture of 21% oxygen, 5% carbon dioxide and 74% argon. The cultures were carried out in presence of 5-25 MicroM CP for 48 hours, then the fragments were fixed, stained and evaluated for the number of hair cells. In presence of 20 MicroM CP the number of external hair cells was ca. 8 per 100 MicroM for culture under air and ca. 11 per 100 MicroM under argon; and in presence of 25 MicroM CP the corresponding figures were ca. 3 per 100 MicroM for culture under air and ca. 8 per 100 MicroM under argon. MECHANISM OF ACTION : None given in the source material.
Patients receive cetuximab 400 mg/m\^2 IV over 120 minutes on day 1 of the first cycle, then 250 mg/m\^2 IV over 60 minutes thereafter. Patients receive cetuximab on days 1, 8 and 15. Patients receive cisplatin 30 mg/m\^2 IV over 30 minutes on days 1 and 8 after cetuximab. Patients also receive irinotecan 65 mg/m\^2 IV over 90 minutes on days 1 and 8 after receiving cisplatin.Treatment repeats every 21 days in the absence of disease progression and unacceptable toxicity.
OBJECTIVE: The objective of this study was the preclinical design and construction of a flexible intrasphenoid coil aiming for submillimeter resolution of the human pituitary gland.
METHODS: Sphenoid sinus measurements determined coil design constraints for use in > 95% of adult patients. Temperature safety parameters were tested. The 2-cm-diameter coil prototype was positioned in the sphenoid sinus of cadaveric human heads utilizing the transnasal endoscopic approach that is used clinically. Signal-to-noise ratio (SNR) was estimated for the transnasal coil prototype compared with a standard clinical head coil. One cadaveric pituitary gland was explanted and histologically examined for correlation to the imaging findings.
RESULTS: With the coil positioned directly atop the sella turcica at a 0° angle of the B0 static field, the craniocaudal distance (21.2 ± 0.8 mm) was the limiting constraint. Phantom experiments showed no detectable change in temperature at two sites over 15 minutes. The flexible coil was placed transnasally in cadaveric specimens using an endoscopic approach. The image quality was subjectively superior at higher spatial resolutions relative to that with the commercial 20-channel head coil. An average 17-fold increase in the SNR was achieved within the pituitary gland. Subtle findings visualized only with the transnasal coil had potential pathological correlation with immunohistochemical findings.
CONCLUSIONS: A transnasal radiofrequency coil feasibly provides a 17-fold boost in the SNR at 3 T. The ability to safely improve the quality of pituitary imaging may be helpful in the identification and subsequent resection of small functional pituitary lesions.
The present invention relates to a composition comprising an active substance wherein said substance comprises a hydrophilic carrier exhibiting a plurality of functional groups selected from i. amino groups, preferably primary or secondary amino groups, ii. hydrazide groups such as –NH-NH2, e.g. as part of a -CONHNH2 group, a semicarbazide group such as -NHCONHNH2, a carbazate group such as -OCONHNH2, a thiosemicarbazide group such as -NHCSNHNH2, a thiocarbazate group such as - OCSNHNH2, iii. aminooxy groups, such as -ONH2 etc, and iv. thiol groups, e.g.-SH; wherein the active substance is in the form of a tablet, powder, granules or freeze- dried particles. The invention further relates to method of treating hair, a kit, a spray bottle and the use of the composition.