anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
[PROBLEMS] Although fucoxanthin extracted from wakame (Undaria pinnatifida) is efficacious as an agent having an antiobesity activity, fucoxanthin is contained in only a small amount in a matured brown alga body and, therefore, it takes a long time and a large cost to obtain a practically usable amount of fucoxanthin. Moreover, it has been required to develop an agent having an enhanced antiobesity activity. Thus, it is intended to specify a carotenoid having a stronger antiobesity activity than fucoxanthin and provide an agent having an antiobesity activity and a method of inhibiting obesity by using the same. [MEANS FOR SOLVING PROBLEMS] As the results of intensive studies for finding a carotenoid having a stronger antiobesity activity than fucoxanthin and a material for economically obtaining the same, it is found out that these problems can be solved by using ascidian. Ascidian is a general name involving marine animals belonging to the phylum Chordata, the subphylum Urochordata, and the class Ascidiacea and these animals widely occur throughout the country. Fucoxanthinol is extracted from, in particular, the internal organs and shell of ascidian and it is clarified that this substance has a strong antiobesity activity.
Scientific studies have shown that there is no clear view on the effects of core exercise models applied on different surfaces, and there are very few studies that observe performance increases in sports activities. Based on this, the aim of this study is to understand more clearly the effects of core stability and core strength exercises performed on stable and unstable ground on selected skills and to implement more functional training programs accordingly. Thus, it is assumed that core training will provide strong positive effects on performance in both athletic and daily activities.

Methods A total of 31 young individuals aged between 18-23, studying at Malatya Inonu University Faculty of Sports Sciences and without any health problems, were included in the study. Participants were divided into three groups: Stable Ground Group (SGG), Unstable Ground Group (USGG) and Control Group (CG). SGG and USGG exercise participants participated in a core exercise program for a total of 25-30 minutes, 2 days a week for 5 weeks. SGG participants performed exercises on a stable floor surface, while USGG participants completed the exercise program on a bosuball. . CG did not participate in any exercise program. CG continued their daily routine activities and maintained their current physical activity levels. The testers were blind to the group (control or training) each subject allocated to. At the end of the exercise protocol, the same procedures applied for the pre-test were applied for the post-test measurements. All tests were performed in an indoor sports hall. All data obtained were recorded on a form created specifically for the study.
The purpose of this study was to investigate the effect of Buerger Allen exercises on lower extremity perfusion and wound healing in type 2 diabetic patients with a diabetic foot ulcer. Subjects were recruited by the researcher in the clinics where they received treatment. Randomized controlled study design was used in the study. Patients in the study were allocated to the control and study intervention groups. The data collection form developed by the researcher was used to collect the data. Patients in both groups received standard wound care. Subjects in the study intervention group were asked to exercise twice daily for 12 weeks. The ulcers and lower extremity perfusion of the groups were assessed in the beginning, in the 4th week, and the 12th week. The groups will be compared in terms of the ulcer size and lower extremity perfusion.
Obesity is acknowledged as a significant risk factor for cardiovascular disease, often accompanied by increased inflammation and diabetes. Bioactive peptides derived from marine animal proteins show promise as safe and effective anti-obesity agents by regulating adipocyte differentiation through the AMPK signaling pathway. Therefore, this study aims to investigate the anti-obesity and anti-diabetic effects of bioactive compounds derived from a Meretrix lusoria Protamex enzymatic hydrolysate (MLP) fraction (≤1 kDa) through a 6-week treatment (150 mg/kg or 300 mg/kg, administered once daily) in leptin receptor-deficient db/db mice. The MLP treatment significantly decreased the body weight, serum total cholesterol, triglycerides, and LDL-cholesterol levels while also exhibiting a beneficial effect on hepatic and serum marker parameters in db/db mice. A histological analysis revealed a reduction in hepatic steatosis and epididymal fat following MLP treatment. Furthermore, poor glucose tolerance was improved, and hepatic antioxidant enzyme activities were elevated in MLP-treated mice compared to db/db control mice. Western blot analysis showed an increased expression of the AMPK protein after MLP treatment. In addition, the expression of lipogenic genes decreased in db/db mice. These findings indicate that bioactive peptides, which are known to regulate blood glucose levels, lipid metabolism, and adipogenesis, could be beneficial functional food additives and pharmaceuticals.
PURPOSE: To provide a enteral nutrient prepn. of high protein, low fat and high calorie having advantages of maintaining the gastrointestinal tracts of an HIV infected person at a normal level and prohibiting the worsening of his immune systems. CONSTITUTION: This nutrient pharmaceutical prepn. for enteral nutrition supplementation for the HIV infected person consists of (A) a first protein source consisting of the soybean protein hydrolysis product(SPH) of which 30 to 60% of the particles have a mol.wt. distribution of 1500 to 5000 dalton measured by a steric exclusion chromatography and more preferably the SPH having a hydrolysis rate is preferably 14 to 17 and <1% in the free amino acid in the amino acid compsn., (B) a second protein source consisting of the flawless (nondecomposed) protein (e.g.; sodium caseinate, whey protein separated matter) of the amt. sufficient for stable emulsification of the SPH and this flawless protein and (C) a fat source (e.g.; fish oil, canola oil) of 1.3:1 to 2.5:1 in the weight ratio of the total sum of n-3 fatty acid to the total sum of n-6 fatty acid.  Dietary fiber sources (e.g.; soybean protein) are further compounded with this prepn.
INTRODUCTION: Primary sclerosing cholangitis (PSC) is the most specific hepatobiliary extraintestinal manifestation in inflammatory bowel disease (IBD). PSC ultimately has a poor prognosis, with disease progression resulting in liver cirrhosis and subsequent liver failure. While there is current data for the medical management of IBD, the optimal approach for concurrent PSC-IBD is unclear.
AREAS COVERED: This review focuses on the current literature of pharmacotherapy in the PSC-IBD population including anti-tumor necrosis factor agents, vedolizumab, JAK inhibitors, IL-12/23 inhibitors, and thiopurines. Regarding PSC-IBD, it focuses on effectiveness of IBD therapies on liver biochemistry and IBD activity as well as the advent of clinically relevant liver outcomes and safety. The authors also address the need for further advances in research.
EXPERT OPINION: The longer-term data for pharmacological management for IBD is well established. In the concomitant PSC-IBD population there is no drug to date that has effectively reduced disease related morbidity and mortality outcomes. There are limitations in the current, mostly retrospective data on IBD drugs in PSC-IBD with respect to samples sizes, heterogenous outcomes, and lack of a high-quality surrogate endpoint in PSC. However, current data for adalimumab offers encouraging results which require further exploration with larger prospective studies.
Genotype-based dietary and physical activity advice can be delivered to young adults before unhealthy lifestyle behaviours or metabolic and physiological conditions have developed. The aim of the present study was to investigate the factors that influence the intention to adopt genotype-based personalised advice on diet and physical activity in young adults who perceive themselves to be a healthy weight versus those who perceive themselves to be overweight or obese. An online survey of 396 young adults (18-25 years) evaluated background factors (participant characteristics (including perception of body weight), psychological factors, belief composites) and constructs of the Theory of Planned Behaviour (TPB) related to the adoption of genotype-based personalised advice. The association between background factors and TPB constructs was assessed using multiple linear regression. The constructs of TPB predicted intention to adopt genotype-based personalised nutrition (P < 0.001, adj. R 2 = 0.54; attitude: B = 0.24, subjective norm: B = 0.25, PBC: B = 0.45). Background factors including belief composites, health locus of control, gender, physical activity, and food choice motives of 'health', 'price', 'familiarity', 'weight control', and 'convenience' significantly added to models of TPB constructs related to the intention to adopt personalised advice (P < 0.05). The influence of background factors varied between TPB constructs and differed based on participants perception of their body weight. The study provides support for the use of the TPB in understanding the intention of young adults to adopt gene-based advice for dietary and physical activity behaviour. In addition to perceived body weight, the background factors identified should help to inform and modify the delivery of advice in behaviour change interventions that seek to use genotype-based personalised advice in young adult populations.
The present invention provides compound fallopia multiflora (thunb.) harald extract micro-pills, which are prepared from a fallopia multiflora (thunb.) harald extract, puerarin and pharmaceutical auxiliary materials, and are characterized in that the pharmaceutical auxiliary materials comprise an excipient and a binder, and the compound fallopia multiflora (thunb.) harald extract micro-pills comprise, by weight, 5-20% of a fallopia multiflora (thunb.) harald extract, 1-5% of puerarin, 70-85% of an excipient, and 1-5% of a binder. According to the present invention, the micro-pill preparation has characteristics of high dissolution rate and high bioavailability, and the preparation method is simple, convenient and easy to operate.
The invention provides a medicinal composition containing a cefamandole nafate compound. The medicinal composition is a powder injection and consists of the following components in parts by weight: 3-15 parts of cefamandole nafate, 0.02-0.5 part of sodium carbonate and 20-100 parts of mannitol. The invention further provides a preparation method of the medicinal composition. The method comprises the following steps of: mixing cefamandole nafate with mannitol to prepare lyophilized powder; preparing anhydrous sodium carbonate into lyophilized powder; uniformly mixing the two types of lyophilized powder; and drying the mixture to obtain the powder injection. According to the medicinal composition powder injection provided by the invention, the stability is enhanced, the storage time is prolonged greatly, and the administration waste and the administration hidden trouble caused by medicament instability are avoided. According to the the preparation method provided by the invention, the influence of CO2 released by dissolving of sodium carbonate on the decomposition of cefamandole nafate is avoided, the content of impurities in a lyophilized powder injection is lowered, and active ingredients are better utilized; and the preparation method is suitable for mass production, and has good application prospect.
The concept of phytochemicals collectively refers to all chemicals made from the root or leaves of a plant. The phytochemicals restrict the growth of a competing plant in a plant itself, or protect the body of the plant from various microbes, harmful insects, etc. Furthermore, the phytochemicals permeate into the body of a person and perform an antioxidative function or a cell damage inhibiting function, thereby maintaining the health of the person. The phytochemicals are being actively researched on the basis of advanced countries such as the United States, Canada, Japan, etc. The known phytochemicals include aspirin extracted from the bark of a willow tree, quinine which is a specific medicine for malaria, phenol and tannin which inhibit generation of carcinogens, etc. As a result of research, it is verified that various fruits and vegetables contain flavonoid, green and yellow vegetables contain carotenoid, and garlic and onion contain allicin, which is a kind of sulfur compound, or the like. Especially, the phytochemicals of vegetables or fruits are contained in great quantities in colorful and dark pigments, and in great quantities in red, orange, yellow, purple and green pigments by color. In addition, the phytochemicals are contained even in white-colored garlic and mushroom and black-colored beans and grains. It is verified that the phytochemicals are rich in vitamins and inorganic salts and have an effect on cancer prevention, antioxidative action, blood cholesterol reduction, inflammation reduction, etc., and the phytochemicals is being actively researched for development of medicines, food ingredients, etc. LB broth is sterilized in an electric rice cooker for 15 minutes. Bacteria supplied from KCTC are streaked and cultured on an LB plate. The bacteria are grown in the LB broth for one day and used in a paper disc method.
Myorisan® is indicated for the treatment of severe recalcitrant nodular acne. Nodules are inflammatory lesions with a diameter of 5 mm or greater. The nodules may become suppurative or hemorrhagic. “Severe,” by definition,2 means “many” as opposed to “few or several” nodules. Because of significant adverse effects associated with its use, Myorisan® should be reserved for patients with severe nodular acne who are unresponsive to conventional therapy, including systemic antibiotics. In addition, Myorisan® is indicated only for those patients who are not pregnant, because Myorisan® can cause life-threatening birth defects (see Boxed CONTRAINDICATIONS AND WARNINGS).

A single course of therapy for 15 to 20 weeks has been shown to result in complete and prolonged remission of disease in many patients.1,3,4 If a second course of therapy is needed, it should not be initiated until at least 8 weeks after completion of the first course, because experience has shown that patients may continue to improve while off Myorisan®. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth (see WARNINGS: Skeletal: Bone Mineral Density, Hyperostosis, Premature Epiphyseal Closure).
Fibro-adipose vascular anomaly (FAVA) is a rare and complex vascular malformation associated with persistent pain, limb contracture, and even restriction of activity. However, the pathophysiology of FAVA remains unclear. Although FAVA is a benign vascular malformation, it is highly misdiagnosed and often thus undergoing repeated surgical resection and interventional sclerotherapy, resulting in worsening of symptoms and irreversible dysfunction. Therefore, aggressive diagnosis and treatment are essential. There are several different treatment options for FAVA, including surgical resection, sclerotherapy, cryoablation, drug therapy, and physical therapy. This article reviews the clinical manifestations, pathological features, pathogenesis, and treatment methods of FAVA.
The sample will be divided into three groups according to the pharmacokinetics of the oral anticoagulant: rivaroxaban 1x/day (group 1); dabigatran and apixabana 2x/day (group 2) and warfarin (control group). Extraction of one to three teeth will be scheduled, in the valley of the new oral anticoagulants' concentration, considered the period of smallest haemorrhagic risk without suspension. In group 1 the surgery will be scheduled 14 hours after the last intake, in group 2 the surgery will be scheduled 8 hours after the last intake, while the control group will undergo the procedure with INR values between 2.0 and 3,0. Hemostatic measures with tranexamic acid paste intra alveolar, suture and biological glue GRF® (gelatin, resorcinol and formaldehyde) and post operative care will be associated. The patients will be contacted after the procedure to inform the presence or absence of late bleeding. The patient should return 24 hours later to evaluate the surgical site. This protocol is based on Guidelines and scientific articles, pharmacokinetics and clinical experience of the authors.
Sham transcranial direct current stimulation (2 mA) plus speech-language therapy for 16 sessions (20-minutes per each 60-minute treatment session) over the course of 8 weeks. Electrodes will be placed as in A-tDCS. Current will be ramped up for the first 30 seconds following which the intensity will drop to 0 mA.
Patients with risk factors for CNS relapse ≥ 2 or with occult meningeal involvement will receive 2 cycles of methotrexate 3g/m2 i.v. after the 3rd and 6th cycle of systemic chemotherapy (R CHOP or DA EPOCH R).
This study is designed to test a new theory of the origin and treatment of ASD. In this theory, ASD is caused by both genes and environment interacting to produce a persistent cell danger response (CDR; Naviaux RK, 2014) that interferes with and alters normal child brain development. Gut microbiome and immune systems are also affected. In this theory, the pathological persistence of the cell danger response is traceable to mitochondria, and maintained by purinergic signaling mediated by the release of extracellular nucleotides like adenosine triphosphate (ATP), adenosine diphosphate (ADP), uridine triphosphate (UTP), and uridine diphosphate (UDP). Suramin inhibits excess purinergic signaling by acting as a competitive inhibitor of nucleotide signaling at both ionotropic purinergic (P2X) receptors, and G-protein coupled, metabotropic purinergic (P2Y) receptors. Suramin has been found to correct the symptoms, metabolism, and brain synaptic abnormalities in two classical genetic and environmental mouse models of autism (Naviaux JC, et al. 2015; Naviaux JC, et al. 2014; Naviaux RK, et al. 2013). This study will test the safety and efficacy of a single dose of suramin in children with ASD. While it is not anticipated that a single dose will produce benefits for more than a few weeks, if successful, this study may lead to the development of newer and safer drugs for autism treatment.
The present invention disclosed a fibrinolysin gene of Agkistrodon acutus, a vector containing the said gene and the host cell which transformed by the vector. The fibrinolysin could be used in treating diseases caused by thrombus. The fibrinolysin FII is purified from the crude venom of Agkistrodon acutus, and the corresponding gene is cloned. It is recommended to produce the fibrionolysin by the yeast expression system. The activity of the fibrionlysin is also determined. The advantages of this invention are hat the expression level and activity of the fibrinolysin are both high and the quality of he fibrinolysin is stable.
Smoking cessation program and activity tracker. Three months low intensity counselling at distance program;subjects smoking behaviour and wellbeing will be assessed at baseline, at 6 months and at one year. Life style will be evaluted by the use of an activity tracker and ad-hoc items.
The purpose of this comparative effectiveness research study is to learn more about different medications called antipsychotics that are used to treat schizophrenia or schizoaffective disorder. Specifically, we are looking at long-acting medications that are given by injection every month, instead of being taken by mouth every day. In this multi-site study, we are comparing the risk and benefits of two FDA-approved long-acting injectable medications (paliperidone palmitate and haloperidol decanoate). Study participants with schizophrenia or schizoaffective disorder are expected to benefit from the improved medication schedule.

This study aims to enroll 360 individuals with schizophrenia or schizoaffective disorder for whom treatment with a long-acting injectable antipsychotic medication is likely to be helpful. Study participants will be randomly assigned to treatment with either paliperidone palmitate and haloperidol decanoate for up to 24 months. Participants will have an equal chance of being assigned to each medication, however participants will not know which medication they are taking.
We present the clinical and radiological characteristics of phalangeal microgeodic syndrome in a cluster of five children during the second peak of COVID-19 pandemic in the UK. Each child presented with phalangeal swelling and erythema, prompting a comprehensive multi-disciplinary team review to analyse the clinical presentation, blood test results and imaging. The cohort's average age was 14.1 years, ranging from 10.4 to 16.6 years, with two girls and three boys. Four children experienced phalangeal involvement in the hands, whilst one was affected solely in the feet. A rheumatological work-up was performed for all. Hand X-rays performed on three children revealed distinct radiographic features like microgeodes, subperiosteal bone resorption and rarefaction in two cases. However, further MRI showed extensive changes closely correlated with the clinical signs of cutaneous vasculopathic rashes. The MRI abnormalities were notable, encompassing marrow oedema primarily affecting metaphyses and epiphyses, displaying broad transition zones. Soft tissue swelling and cortical erosions were also observed. These MRI features proved more pathognomonic in the acute clinical context. The study concluded that phalangeal microgeodic syndrome, characterised by digital swelling and erythema, might not be adequately assessed by plain X-rays. The more comprehensive MRI features, including marrow oedema and soft tissue abnormalities, appeared to be more indicative in diagnosing the condition. Considering the rarity of this syndrome and its temporal association with the COVID-19 pandemic, the study hypothesised that COVID-related thrombophilia and immune-mediated vasculopathy might act as crucial triggers for the active bony manifestations seen in this syndrome. KEY POINTS: • PMS is a rare, predominantly paediatric condition, of unknown aetiology which affects the digits. • Laboratory investigations are generally negative; however, in the appropriate clinical context, the X-ray findings of microgeodes and pattern of bone marrow oedema seen on MRI are pathognomonic. • Considering the rarity of PMS and temporal association with the COVID-19 pandemic, COVID vasculopathy may represent a previously unrecognised aetiology for PMS.
This study aimed to investigate the association between physical activity, sedentary behaviour and chronic inflammation in short sleep adults. The study included 2,113 NHANES participants with self-reported insufficient sleep. C-reactive protein (CRP) was used as the inflammatory biomarker. Physical activity and sedentary behaviour were objectively measured by accelerometers. Weighted regression model, two - piecewise linear regression model, and restricted cubic splines were applied to evaluate associations mentioned above. An isotemporal substitution model was used to assess the modelled effects of replacing sedentary time (ST) with moderate-to-vigorous levels of physical activity (MVPA) or light physical activity (LPA). After adjusting for potential confounding factors, higher levels of ST and lower levels of LPA or MVPA were associated with higher CRP levels. Isotemporal substitution analysis indicated that replacing 30 minutes of ST with 30 minutes of MVPA was associated with a significant decrease in CRP levels. Saturation analysis suggested that the association between MVPA and CRP may plateau at over 20 minutes of MVPA per day. Findings of this study provides insight into the potential benefits of replacing ST with MVPA. This study also suggests that increasing MVPA beyond a certain point may not provide additional anti-inflammatory benefits in a short sleep population.