anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Osteoporotic fractures such as hip fractures and severe fractures are associated with increased morbidity and mortality and impose a large financial burden on healthcare systems. Patients with osteoporosis-related fractures are at higher risk of subsequent fractures. Other severe fractures (pelvis, vertebrae, humerus) have similar consequences, pelvis. The risk of refracture after fracture depends on the time: it is 5 times higher in the first 2-3 years, and 2 times higher after. This notion of Imminent Fracture Risk is the basis for the development of post-fracture care pathways called "fracture liaison. The implementation of FLS is the most effective way to reduce the risk of secondary fracture. Despite their success, FLS programs are not an integral part of post-fracture care throughout the France. The investigators believe that the barriers to the implementation of such a pathway are multiple and are largely related to the lack of accessibility for patients to FLS, and to the mobilization of important and unsustainable human resources. Some French public hospitals or institutions are currently building some e_FLS models based on an automatic detection of patients with fractures, and a on a cloud-based system where practitioners across the health care sector can communicate and jointly manage osteoporotic patients. The investigators' hypothesis is that this web FLS (e_FLS) is at least as effective as the classical FLS for the secondary fracture prevention.

The objective of the investigators' study is to compare web FLS model (e_FLS) to conventional FLS in terms of increasing the proportion of patients receiving an antiosteoporotic treatment in the year after a low trauma fracture (evAB project).
Aneurysmal bone cysts (ABC) are relatively rare, benign, tumor-like, expansile osteolytic lesions of unknown etiology which are predominantly found within the long bones and characterized by frequent idiopathic fractures. Despite the large variety of bone substitutes that have been used to fill these cystic lesions, to date there is no graft material which can be regarded as completely satisfactory, with a recurrence rate that ranges from 5-40% of treated cases. Autologous bone marrow derived mononuclear cells have been used previously to treat ABCs. Poly lactic-co-glycolic acid (PLGA) scaffolds have been used in bone tissue engineering due to their biodegradability and biocompatibility. Human platelet lysate (PL) contains a number of mitogenic growth factors and has been demonstrated to enhance mesenchymal stem cell (MSC) proliferation and expansion rate in vitro. This study is designed to assess the safety and effectiveness of using PLGA scaffolds seeded with autologous bone marrow MSCs and supplemented with osteogenic media and platelet lysate in healing bone lesions of patients suffering from aneurysmal bone cysts. This study will be conducted at the Cell Therapy Center (CTC), Jordan. Four ABC cases will be included. Patients qualified for this study are those diagnosed with ABCs and failed to be treated with other forms of classical therapies; such as allografts or who are not candidate of autografts.
PURPOSE: Outpatient lumbar decompression surgeries have been successfully performed in France for over twenty years, earning acceptance. However, outpatient instrumented lumbar spine procedures and arthroplasties are less documented. This study aimed to evaluate the feasibility, efficiency, and safety of outpatient lumbar instrumented surgery.
METHODS: A prospective single-center study involving three experienced surgeons was conducted from September 2020 to September 2021, with a minimum six-month postoperative follow-up. Inclusion criteria comprised patients aged 18 to 75 eligible for same-day discharge, undergoing single-level lumbar spinal fusion or arthroplasty via anterior or posterior Wiltse approach. The primary endpoint was assessing the percentage of successful outpatient discharges (within twelve hours), with secondary endpoints including perioperative/postoperative complications and discharge pain prescriptions in terms of frequency and severity.
RESULTS: Forty patients (mean age: 44 years; 16/24 male/female ratio) underwent surgery, including 18 lumbar arthroplasties, twelve ALIF, and ten TLIF procedures. The majority of surgeries were performed at L4-L5 (18 procedures) and L5-S1 levels (22 procedures). 95% (38/40) of patients were successfully discharged within twelve hours, with only two patients discharged the following day. No postoperative hematomas, serious adverse events, or revision surgeries were noted.
CONCLUSION: 95% of patients were discharged successfully within twelve hours following outpatient lumbar fusion surgery, with a 100% patient satisfaction rate. Specific technical solutions were not necessary, and oral pain relief sufficed. Patient selection and education, including early pain management, played crucial roles in complication avoidance. This study underscores the safety of outpatient instrumented lumbar spine procedures, leading to cost reduction and expedited recovery.
All participants will receive trainings for 90 minutes per day, three days per week for 12 weeks (a total of 36 training sessions). Each physical exercise intervention session will last for 90 minutes. The entire exercise program for the PE group will contain 10 minutes of warm-up, 70 minutes of physical exercise, and 10 minutes of cool-down. The PE group received multimodal exercise program which includes aerobic exercise, balance and muscle strength training.
A psychological counseling assistive system employing immersive virtual reality (VR) and interpersonal relationship sculpture comprises an interpersonal relationship sculpture construction module and a VR experience module. The interpersonal relationship sculpture construction module comprises an interpersonal relationship sculpture construction basic function module and an interpersonal relationship sculpture construction interaction module. The VR experience module comprises a VR experience function module and a role interaction function module. A VR technique and an interpersonal relationship sculpture technique are combined to allow a visitor to have an immersive experience of an embodiment of a psychophysical field. A character model is used to implement an interpersonal relationship sculpture function that would normally require multiple participants in conventional group psychological intervention. In addition, compared with conventional one-to-one conversation-based intervention, i.e., individual psychological intervention, the system is intuitive and effective, and employs multiple sense channels of the visitor to perform counseling. Using a character model to complete sculpture further facilitates rapid and accurate character interaction.
PURPOSE:A cosmetic, containing a condensate of an alkyl ester of an amino acid with a protein and/or a salt thereof, finishing the skin or hair in a moist, fresh and nonsticky state, and capable of exhibiting moisturizing effect by remaining on the skin or hair. CONSTITUTION:A cosmetic containing 1-15wt% condensate of an alkyl ester of an amino acid having a 4-12C alkyl group with a protein and/or a salt thereof as a moisturizer. The above-mentioned cosmetic is used for all of the skin or hair as an object, and capable of retaining moderate moisture on the surface of the skin or hair by remaining moderately thereon. The alkyl ester of the amino acid is obtained by reacting a 4-12C monohydric alcohol with an amino acid, e.g. phenylalanine, in an organic solvent in the presence of p-toluenesulfonic acid as a catalyst, etc., and the resultant alkyl ester is incorporated with the protein in an aqueous solution system and reacted therewith in the presence of papain, etc. as a catalyst to give the aimed substance.
Once hemostasis is obtained, the Suprathel material will be handled with a new pair of sterile gloves. It will be cut so that the material extends 1-2 cm beyond the donor site margins, then applied to the donor site. The Suprathel will be secured with a protective layer of Rylon extending 1-2 cms beyond the margins of the Suprathel. The primary dressing will be covered with cotton gauze (4x4 fluff gauze pads) and wrapped with rolled gauze). The outer dressing will be changed 7-10 days post-op. The Suprathel and Rylon will remain in place until they can be easily peeled off. To facilitate the pain-free and easy removal of the primary Suprathel dressing, practioners will apply Vaseline or lotion to saturate and loosen the material. The patients will be followed on average about once per week in an outpatient clinic until the Suprathel (and Rylon) are removed, but they may continue to be seen until the STSG is fully healed.
Corticotropin-releasing hormone-binding protein (CRHBP) is involved in many physiological processes. However, it is still unclear what role CRHBP has in tumor immunity and prognosis prediction. Using databases such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Tumor Protein Database, Timer Database, and Gene Expression Profiling Interactive Analysis (GEPIA), we evaluated the potential role of CRHBP in diverse cancers. Further research looked into the relationships between CRHBP and tumor survival prognosis, immune infiltration, immune checkpoint (ICP) indicators, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), DNA methylation, tumor microenvironment (TME), and drug responsiveness. The anticancer effect of CRHBP in liver hepatocellular carcinoma (LIHC) was shown by Western blotting, EdU staining, JC-1 staining, transwell test, and wound healing assays. CRHBP expression is significantly low in the majority of tumor types and is associated with survival prognosis, ICP markers, TMB, and microsatellite instability (MSI). The expression of CRHBP was found to be substantially related to the quantity of six immune cell types, as well as the interstitial and immunological scores, showing that CRHBP has a substantial impact in the TME. We also noticed a link between the IC50 of a number of anticancer medicines and the degree of CRHBP expression. CRHBP-related signaling pathways were discovered using functional enrichment. Cox regression analysis showed that CRHBP expression was an independent prognostic factor for LIHC. CRHBP has a tumor suppressor function in LIHC, according to cell and molecular biology trials. CRHBP has a significant impact on tumor immunity, treatment, and prognosis, and has the potential as a cancer treatment target and prognostic indicator.
Patients receive pembrolizumab IV over 30 minutes on day 1 and doxorubicin hydrochloride IV over 1-3 hours on day 1 of courses 2-7 only. Treatment repeats every 21 days for up to 35 courses in the absence of disease progression or unacceptable toxicity.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to otorhinolaryngology, and can be used for drainage of paranasal sinuses in patients with consciousness disorders. That is ensured by drainage from the sinus cavity by means of a drain element using positive and negative pressure during drainage. Drainage element used is a flow-flushing drainage element consisting of two tubes of elastic material with rounded ends. One of the tubes is intended for aspiration and has an end having perforation in the form of side holes. Other tube is used as an irrigator tube. After the endonasal endoscopic operation, an endoscopic inspection is followed by installing a drainage tube for aspiration into the involved paranasal sinus or sinuses. Pipe for aspiration is installed so that its perforated end does not extend beyond sinus. Vacuum aspirator operated in a constant low vacuum mode is connected to the perforated end of the aspiration tube, namely, less than 20 kPa. Drop introduction system for medicinal preparations is connected to an irrigation tube. Further, by means of said flow-washing drainage element, drainage from sinuses with continuous aspiration of flushing liquid is performed for 4–6 days. At the same time aspiration is followed by administering a sterile aqueous solution of 0.05 % chlorhexidine from the drip introduction system at rate of 60 drops a minute.EFFECT: method provides accelerating the sanation time of the infection center, reducing the number of complications in the postoperative period.1 cl, 1 dwg, 1 ex
PURPOSE: To obtain a compression molded preparation by using a preparation additive readily obtainable in the market, having reduced damage of coating film. CONSTITUTION: This compression molded preparation is obtained by compression molding medicine-containing coated particles in the presence of a finely granular film protecting agent. The film protecting agent is fine particles of a substance showing >=50μm average particle diameter and >=4 initial elution rate. A water-soluble saccharide (e.g. glucose), a cellulose derivative (e.g. a carboxyalkyl cellulose), a polysaccharide (e.g. maize starch), a synthetic polymer compound (e.g. polyethylene glycol), a silicon compound (e.g. silicic acid), an alkali metal salt, an alkaline earth metal salt (e.g. calcium carbonate), etc., may be cited as the film protecting agent.  The medicine- containing coated particles are obtained by providing a core substance containing one or more medicines with a coating film for the purpose of sustained release, flavor, improvement in stability, surface modification, etc., and are in sizes of about 30-1,000μm. The medicine-containing coated particles are mixed with the film protecting agent in the ratio of (19:1) to (1:99). The compression molded preparation has higher preparation hardness than that molded by using a protecting agent having a lager particle diameter under the same pressure.
INTRODUCTION: Clinical trial data indicate that omitting axillary lymph node dissection (ALND) is feasible and may reduce morbidity for carefully selected patients with clinically node-positive breast cancer who achieve a pathological complete response (pCR) after neoadjuvant chemotherapy (NCT). However, there remains a need to understand how these findings translate to broader clinical practice and to identify which patients benefit most. This study utilizes a national dataset to assess outcomes in axillary management, aiming to inform best practice in axillary de-escalation.
METHODS: The National Cancer Data Base was used to identify women diagnosed with clinically node-positive invasive breast cancer between 2012 to 2020 who received NCT and subsequent ALND. Associations between clinicopathologic factors and axillary pCR were analyzed statistically.
RESULTS: Of the 59,791 patients included, 8,827 (14.76%) achieved nodal pCR. Patients with HR-negative and HER2-positive receptor status more frequently underwent ALND instead of sentinel lymph node biopsy. Conversely, patients over the age of 70, those with private or public insurance, and cases classified as ypT1 or ypT2 were less likely to undergo ALND.
CONCLUSION: A subset of patients with clinically node-positive breast cancer received ALND despite achieving axillary pCR following NCT. This highlights an opportunity to enhance precision in identifying candidates for axillary de-escalation, potentially reducing morbidity and tailoring treatment more closely to individual patient needs.
Subjects in this condition will receive usual counseling care during the entire 6 months of study participation. They will receive voucher reinforcement, and will have the opportunity to earn voucher incentives during the first 3-months of care (13 weeks).
PURPOSE: To alleviate symptoms of animal acquired immune deficiency syndrome, by administering a substance characteristic to an acquired immune deficiency syndrome- afficted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a positive wheal upon subcutaneous administration, to an animal except human. CONSTITUTION: This method for alleviating symptoms of acquired immune deficiency syndrome of an animal (e.g. cat) except human comprises administering a substance (e.g. human hormone for stimulating villi sex glands, etc.), characteristic to an acquired immune deficiency syndrome-afficted cell in aft amount less than the lowest amount necessary to provoke a humoral immune response, exemplified by the existence of a positive wheal upon subcutaneous administration, its pharmaceutically effective fragment and pharmaceutically effective derivative thereof together with an immunostimulator (e.g. bacterial lysate) in an amount less than the lowest amount necessary to provoke a humoral immune response in cooperation with the substance to the animal except human to effectively alleviate the symptoms of acquired immune deficiency syndrome of an animal except human.
Novel techniques are described for network tracking of contagion propagation through host populations. For example, location information of networked devices can be tracked and stored to generate contact profiles of individuals with respect to other individuals in the population. One or more contagion profiles can also be stored in association with respective one or more pathogens to identify propagation characteristics of the pathogen. Responsive to an individual being diagnosed as an infected individual with respect to a particular contagious pathogen, a propagation model can automatically be generated for the infected individual based on the contagion profile of the particular contagious pathogen and the contact profile of the infected individual. The propagation model can be used to identify one or more suspect populations as having at least a threshold likelihood of having been infected by the infected individual. A response protocol can automatically be generated according to the pathogen-specific propagation model.
The invention discloses a short sleeve. The short sleeve is made through weaving Coolmax fibers and cotton fibers and carrying out antibiosis treatment. The short sleeve reserves the high perspiration capability of the Coolmax fibers, and the antibiosis treatment makes the short sleeve have extremely strong bacterium inhibition capability. The short sleeve corresponding to the human body spinal column is provided with a long and narrow medicinal material layer, the back of the short sleeve is coated with the medicinal material layer through a textile adhesive, and the medicinal material layer comprises sinalbin, tourmalinite powder and vanillyl butyl ether; and the above three medicinal materials commonly act on the spinal column to improve local blood circulation and increase metabolism. The front side or/and the back side of the short sleeve is/are provided with a fluorescent layer, and the fluorescent layer is made of a fluorescent fabric. The fluorescent fabric has the advantages of avoiding of dropping of a fluorescent material, caused by multi-time washing, protection f the integrity of a fluorescence pattern, and good safety.
Cirrhosis of the liver is a common clinical chronic progressive liver disease, which is a diffuse liver lesion caused by one or more causes over a long period of time or repeatedly. Nodules, abnormal spherical areas of cells, form as dying liver cells are replaced by regenerating cells. This regeneration of cells causes the liver to become hard. Decompensated liver cirrhosis is mainly manifested by liver function damage and portal hypertension, with multiple system involvement. Complications such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, and carcinogenesis often occur in the late stage. The potential for stem cells to differentiate into hepatocytes cells was recently confirmed. In particular, mesenchymal stem cell (MSC) and Tregs transplantation had been applicated in the clinic for treat several human diseases such as liver injury and liver fibrosis displayed good tolerance and efficiency. The purpose of this study is to learn whether and how MSCs and Tregs can improve the disease conditions in patients with decompensated cirrhosis.
Patients receive chemotherapy comprising fludarabine phosphate and cyclophosphamide as determined by the referring physician in consultation with the protocol PI. Beginning within 36-96 hours after completion of lymphodepleting chemotherapy, patients receive ROR1 CAR-specific autologous T-lymphocytes IV over 20-30 minutes. Patients may receive a second infusion of ROR1 CAR-specific autologous T-lymphocytes with or without additional cytoreductive therapy at the same (for those that received the highest cell dose) or up to the next highest dose level and there is persistent disease, there were no toxicities attributed to the first infusion, and the patient is at least 21 days from the first T cell infusion.
This study aims to investigate how non-invasive, non-significant risk EMG monitoring can be used intraoperatively to objectively characterize neuraxial anesthesia (i.e. spinal and caudal blockade) in pediatric patients undergoing surgery. The investigators will also attempt to measure the effect of adjunctive intrathecal clonidine on spinal and caudal blockade using EMG. This study also aims to quantify the impact of sevoflurane on basal muscle tone based on EMG changes. This study aims to generate pilot data on this subject to help design future studies. The hypothesis is that EMG monitoring can be utilized to objectively measure neuraxial blockade, including onset, resolution, density, and dermatomal level.