anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of the invention is to treat patients with tumoral diseases by selectively removing their B-lymphocytes. Tumoral cells can be specifically identified by cytotoxic T-lymphocytes of the CD8 subtype. To do so, they require the help of auxiliary T-lymphocytes of the CD4 subtype. In the presence of B-lymphocytes, the assistance of T-cells is excluded. The B-lymphocytes actively prevent the development of T-cell mediated tumoral cell destruction. The invention is based on a mechanism of the immune system discovered by the inventors, wherein CD4+ T-cells, when they receive the antigens of tumor cells of B-cells, are differentiated to form a phenotype which prevents them from providing assistance to CD8+ cytotoxic T-cells which they require in order to mediate systemic tumoral immunity. In the absence of B-cells, other antigen-presenting cells present the tumoral antigens to the CD4+ T-cells so that they are differentiated to form T cells which can help the cytotoxic CD8+ T-cells to destroy the tumoral cells. The inventive method is also suitable for use in combination with tumor-specific vaccination and can basically be used to treat any type of tumoral disease. The inventive agent for enhanced cellular immune-response to tumors comprises substances which remove or inactivate the lymphocytes of patients. The invention can be used in medicine and the pharmaceutical industry.
A commercial reference cream, not containing berry and plant oils. Study part 2: Administered to randomized body half 1-2 times/d for five weeks.
The invention relates to a bacteriophage and antimicrobial application thereof, in particular to a methicillin-resistant staphylococcus epidermidis staphylococcus aureus bacteriophage and antimicrobial application thereof, and belongs to the field of bioengineering. The methicillin-resistant staphylococcus epidermidis staphylococcus aureus bacteriophage is preserved in China Center for Type Culture Collection (CCTCC), located in Wuhan University of Wuhan of China, on September 17, 2015. The collection number is staphylococcus aureus bacteriophage qdsa002 of CCTCC M2015554. The Latin scientific name is staphylococcus aureus bacteriophage qdsa002. The bacteriophage has high splitting effect on staphylococcus aureus, especially methicillin-resistant staphylococcus epidermidis staphylococcus aureus. The preparation can be used individually or compounded with other drugs, and a safe bacteriophage product source free of toxic and side effects is provided for control of methicillin-resistant staphylococcus epidermidis staphylococcus aureus contamination.
Patients randomized in the Arm A will undergo to 6 courses of systemic chemotherapy according to FOLFOX regimen, after these six courses of chemotherapy, radiologic restaging (CT scan) as well as a second staging laparoscopy will be performed. If a Progression Disease will be detected, the patient will end the trial and will undergo to II line chemotherapy regimen. If a stable disease or a partial response will be documented, after a multidisciplinary discussion, patient will undergo to either further 6 courses of chemotherapy or to cytoreductive surgery plus HIPEC.
Cisplatin is a widely used and effective chemotherapy in the treatment of adult and pediatric solid tumors, including bladder, testicular, head and neck, and lung cancers. Serious side effects of cisplatin treatment include ototoxicity. To date, no approved therapy to prevent or treat ototoxicity exists for people receiving cisplatin treatment, which remains the most common dose-limiting side effect associated with cisplatin administration.

Participants who will be undergoing cancer treatment with high doses of cisplatin every 21 or 28 days will receive IT injection with one ear receiving DB-020 and one ear receiving placebo during each administration. The study will comprise 2 parts. In Part A, eligible participants will be randomized to one of two doses of DB-020. In Part B, participants will be treated with a single dose of DB-020, as selected from data collected in Part A. In both Parts A and B, the ear receiving DB-020 or placebo will be randomized. The choice of dose in Part B will depend on the data from Part A. If appropriate safety and efficacy is observed at either dose level, the Sponsor has the option of dosing at one of these concentrations either unilaterally (ie, with placebo administered in the contralateral ear) or bilaterally (ie, open-label DB-020 administered to both ears) in Part B.
PURPOSE:To enable the diagnosing or the like of ST waves and QRS waves especially vital in electrocardiography by a method wherein an electrocardiographic complex is recorded at reference sensitivity and subsequently, one heart beat alone is recorded at the sensitivity half as much as the reference sensitivity again without duplication or the like in the electrocardiographic complex with the frame of a recording paper trimmed in the recording at the reference sensitivity. CONSTITUTION:When electrocardiogram information during a measurement is printed and recorded with a recording section, 2 recording key of a keyboard 11 is depressed to input. Detecting the depression of the recording key through a keyboard control circuit 9, a main CPU1 starts a recording control 20 and a member induction of an electrocardiographic complex measured is printed and outputted from the recording section 21. At the recording section 21, firstly, I-III induction is printed and recorded by a specified number of heart beats. Checking is performed to see whether the electrocardiographic complex measured as recorded is within a recording area of the recording section 21. When it is not within the recording area, the electrocardiographic complex is reduced so that it is held within the recording area and the printing and recording is performed following the preceding record. For example, the recording is performed at sensitivity half as much as the preceding reference sensitivity.
Training will involve maintaining accurate representations of cognitive context (the "rule") in working memory during response selection. On each training trial, participants must observe stimuli, and hold the correct response context "on-line" in order to select the correct response from among the stimuli. Training is adaptive using a staircase function, such that two consecutive correct responses increases either the speed of stimuli presentation or the working memory load via an increased number of stimuli that are presented; one incorrect response reduces the cognitive load. Each session will consist of 45 exercises requiring \~45 minutes.
FIELD: biotechnology, vaccines. SUBSTANCE: invention relates to preparing highly immune vaccine. Rickettsia (Coxiellae) Bernett accumulation is carried out in murine spleens and their isolation and purification from host tissues is carried out in system of incompatible polymers. Part of the obtained purified corpuscular antigen is used as the first component of vaccine. Other part of corpuscular antigen is subjected for ultrasonic treatment and centrifugation and soluble antigen is obtained as the second component of vaccine. Components 1 and 2 were combined at ratio: 16 mcg Coxiella corpuscles and 0.5 ml soluble antigen at titer 1:10. The prepared vaccine shows high immunogenic activity, prolonged immunity retention at a single vaccination and safety. EFFECT: improved method of preparing, enhanced quality and property.
The incidence of childhood obesity in the United States has steadily increased over the past 30 years, but has begun to level off in recent years. Children from minority groups may be disproportionately affected, such that Hispanic and non-Hispanic Black children have greater weight for recumbent length compared to White children. Similarly, socioeconomic status (SES) may affect child weight status. Epidemiological evidence indicates that obesity may transmitted across multiple generations. Genetics are a factor in determining weight status, but parents are largely responsible for regulating children's dietary environments. Grandparents increasingly provide care for their grandchildren, yet few studies have examined grandparent involvement or the role that grandparents or other significant caregivers play in feeding the child.

The objective of the current study is two-fold: 1) to evaluate the extent to which mothers and other caregivers affect mothers' parenting surrounding feeding their infant, beginning when the infant is first introduced to solid foods; and 2) to examine whether an intervention aimed at providing both mothers and and other important caregivers with hands-on training regarding healthy foods and responsive and sensitive feeding behaviors improves mothers' and other caregivers' responsive and sensitive behaviors and infants' weight trajectories over time. The researchers will collect both self-report data on diet, child temperament, mothers and caregiver mental health, stress and support. Observational assessments will be obtained to code co-caregiver behavior and caregiver responsiveness during feeding.
Depression is a prevalent mental disorder characterized by unknown pathogenesis and challenging treatment. Recent meta-analyses reveal an association between cardiovascular risk factors and an elevated risk of depression. Despite this, the precise role of vascular injury in depression development remains unclear. In this investigation, we assess vascular system function in three established animal models of depression- chronic unpredictable mild stress (CUMS), chronic social defeat stress (CSDS) and maternal separation (MS)-utilizing ultrasonography and laser Doppler measurement. All three model animals exhibit anhedonia and despair-like behavior. However, significant microvascular dysfunction (not macrovascular) is observed in animals subjected to CUMS and CSDS models, while such dysfunction is absent in the MS model. Statistical analysis further indicates that microcirculation dysfunction is not only associated with depression-like behavior but is also intricately involved in the development of depression in the CUMS and CSDS models. Furthermore, our study has proved for the first time that endothelial nitric oxide synthase-deficient (eNOS+/-) mice, which is a classic model of vascular endothelial injury, showed depression-like behavior which occurred two months later than microvascular dysfunction. Notably, the mitigation of microvascular dysfunction successfully reverses depression-like behavior in eNOS+/- mice by enhancing nitric oxide production. In conclusion, this study unveils the pivotal role of microvascular dysfunction in the onset of depression induced by chronic stress in adulthood and proposes that modulating microvascular function may serve as a potential intervention in the treatment of depression.
The invention discloses a traditional Chinese medicine prescription for treating calculus of a bile duct. The traditional Chinese medicine prescription can treat a dampness and heat case. The treatment is carried out by main methods including: promoting circulation of vital energy in a liver and a gall, promoting blood circulation to remove blood stasis and eliminating dampness. In order to achieve the purpose, the following technical scheme is adopted. A medicine for soothing the liver and the gall is prepared by a weight ratio and mainly comprises main components and an auxiliary component. The main components comprises 9g of the roots of Chinese thorowax, 9g of white peony roots, 9g of turmeric root tubers, 15g of turmeric, 9g of oriental wormwoods, 9g of Baikal skullcap roots. 9g of elecampane, 9g of bitter oranges, 6g of Chinese rhubarbs (after discharge)  and 6g of sodium sulfates (after discharge), and the auxiliary component comprises 1000ml of water.
An educational augmented reality auscultation system (EARS) is proposed to enhance the reality of auscultation training using a simulated patient. The conventional EARS cannot accurately reproduce breath sounds according to the breathing of a simulated patient because the system instructs the breathing rhythm. In this study, we propose breath measurement methods that can be integrated into the chest piece of a stethoscope. We investigate methods using the thoracic variations and frequency characteristics of breath sounds. An accelerometer, a magnetic sensor, a gyro sensor, a pressure sensor, and a microphone were selected as the sensors. For measurement with the magnetic sensor, we proposed a method by detecting the breathing waveform in terms of changes in the magnetic field accompanying the surface deformation of the stethoscope based on thoracic variations using a magnet. During breath sound measurement, the frequency spectra of the breath sounds acquired by the built-in microphone were calculated. The breathing waveforms were obtained from the difference in characteristics between the breath sounds during exhalation and inhalation. The result showed the average value of the correlation coefficient with the reference value reached 0.45, indicating the effectiveness of this method as a breath measurement method. And the evaluations suggest more accurate breathing waveforms can be obtained by selecting the measurement method according to breathing method and measurement point.
In order to more widely provide a high-quality early detection method of and preventive treatment for ophthalmologic disease, a server in this ophthalmic examination support system has a medical information storage device for storing patients' medical information, and a management device for managing the same. Multiple clients are capable of communicating with the management device. An association information storage unit pre-stores association information which associates prescribed items of medical information and examination conditions for ophthalmic examination. From the association information, the examination condition acquisition unit acquires examination conditions associated with medical information corresponding to patient information transmitted from a client. A control unit of the clients performs control on the basis of the acquired examination conditions. A control unit of the management device receives medical information including the examination data about the patient's eyes transmitted together with the patient information from the client and stores this information in the medical information storage device. A first update unit of the management device statistically processes the medical information in the medical information storage device and updates the association information.
Cohort 3 will enroll participants aged 2 to less than 18 years. SS3 is a 208-week extension period where participants receive risankizumab based on their response in SS2.
The present invention relates to nematicides, which are compositions that kill nematodes when placed in physical contact with nematodes. Nematodes do not decompose organic matter, but, instead, are parasitic and free-living organisms that feed on living material.  M. incognita  is a root knot nematode that has the ability to cause infection in more than 2,000 species of plants. Specifically, the present invention relates to CED-4 peptides that effectively kill nematodes. These CED-4 peptides are segments of the CED-4 protein. This invention is directed to a nematicide composition comprising an effective amount of a CED-4 peptide consisting of no more than 50 amino acids. In one aspect of the invention, the nematicide composition consists of no more than 30 amino acids. In another aspect of the invention, the nematicide consists of no more than 20 amino acids.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a composition that has a physiologically active peptide of the general formula:   where X means acyl-group; R 1 , R 2  and R 4  each means aromatic cyclic group; R 3  means a residue of D-amino acid or a group of the formula:   where   means heterocyclic group; R 5  means a group of the formula   where n = 2 or 3, and   means amino-group that can be substituted optionally, aromatic cyclic group or O-glycosyl-group; R 6  means a group of the formula   where n = 2 or 3, and   means amino-group that can be substituted optionally; R 7  means a residue of D-amino acid or azaglycyl-residue; Q means hydrogen atom or lower alkyl-group, or its salt and biodegradable polymer bearing a terminal carboxyl-group. Composition is prepared by dissolving of components mixture in water-insoluble solvent followed by solvent removing. Preparation of delayed releasing ensures to obtain noncontinuous release of peptide for the long time without initial release as compared with the known similar compositions. EFFECT: improved method of preparing, enhanced effectiveness of composition proposed. 25 cl, 9 tbl, 45 ex
The behavior of the individual components is described below:   
Hydrocodone: Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was 23.6 ± 5.2 ng/mL. Maximum serum levels were achieved at 1.3 ± 0.3 hours and the half-life was determined to be 3.8 ± 0.3 hours. Hydrocodone exhibits a complex pattern of metabolism including O-demethylation, N-demethylation and 6-keto reduction to the corresponding 6-α- and 6-β-hydroxy-metabolites. See OVERDOSAGE for toxicity information. 

Acetaminophen: Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug. See OVERDOSAGE for toxicity information.
Artificial intelligence (AI) is rapidly transforming the field of medicine, announcing a new era of innovation and efficiency. Among AI programs designed for general use, ChatGPT holds a prominent position, using an innovative language model developed by OpenAI. Thanks to the use of deep learning techniques, ChatGPT stands out as an exceptionally viable tool, renowned for generating human-like responses to queries. Various medical specialties, including rheumatology, oncology, psychiatry, internal medicine, and ophthalmology, have been explored for ChatGPT integration, with pilot studies and trials revealing each field's potential benefits and challenges. However, the field of genetics and genetic counseling, as well as that of rare disorders, represents an area suitable for exploration, with its complex datasets and the need for personalized patient care. In this review, we synthesize the wide range of potential applications for ChatGPT in the medical field, highlighting its benefits and limitations. We pay special attention to rare and genetic disorders, aiming to shed light on the future roles of AI-driven chatbots in healthcare. Our goal is to pave the way for a healthcare system that is more knowledgeable, efficient, and centered around patient needs.
### Neonates with a history of in utero exposure to benazepril hydrochloride:

If oliguria or hypotension occurs, direct attention toward support of blood pressure and renal perfusion. Exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function. Benazepril, which crosses the placenta, can theoretically be removed from the neonatal circulation by these means; there are occasional reports of benefit from these maneuvers with another ACE inhibitor, but experience is limited.

The antihypertensive effects of benazepril hydrochloride tablets have been evaluated in a double-blind study in pediatric patients 7 to 16 years of age (see CLINICAL PHARMACOLOGY: Pharmacodynamics,  Hypertension). The pharmacokinetics of benazepril hydrochloride tablets have been evaluated in pediatric patients 6 to 16 years of age (see CLINICAL PHARMACOLOGY:  Pharmacokinetics and Metabolism). Benazepril hydrochloride tablets were generally well tolerated and adverse effects were similar to those described in adults. (See ADVERSE REACTIONS: Pediatric Patients). The long-term effects of benazepril on growth and development have not been studied. Infants below the age of 1 year should not be given benazepril hydrochloride tablets because of the risk of effects on kidney development. 

Treatment with benazepril hydrochloride tablets is not recommended in pediatric patients less than 6 years of age (see ADVERSE REACTIONS), and in children with glomerular filtration rate <30 mL/min as there are insufficient data available to support a dosing recommendation in these groups. (See CLINICAL PHARMACOLOGY: Pharmacokinetics and Metabolism, In Pediatric Patients and DOSAGE AND ADMINISTRATION.)
The information relates to a lipid preparation embodied in the form of a sti ck or a supple paste which is adapted for cosmetic use, in particular in the field of decorative cosmetics for colouring or treating skin, lips and eyelids. Said paste can be also used as a lips gloss, lipstick fixative, lip s care, a base for skin care and a sun-protection product. The inventive lipid preparation is embodied in an anhydride form and contains exclusively a liqu id phase of vegetable raw materials. The combination of hydrogenated jojoba oil (INCI: hydrogenated Jojoba oil) and the essential oil of bittercress grains (INCI: Limnanthes Alba) exhibits particularly useful properties. Said preparation can also contain colorants and appropriated cosmetic active substances. The inventive methods for producing said preparation and using vegetable raw materials or vegetable-based or natural perfumes or identical to natural or the mixture thereof in order to preserve the lipid anhydride preparations are also disclosed.
Meningiomas are the most frequent nonmalignant tumors of the central nervous system (CNS). Despite their benign nature and slow-growing pattern, if not diagnosed early, these tumors may reach relatively large sizes causing significant morbidity and mortality. Some variants are located in hard-to-access locations, compressing critical neurovascular structures, and making the surgical management even more challenging. Although most meningiomas have a good long-term prognosis after treatment, there are still controversies over their management in a subset of cases. While surgery is the first-line treatment, the use of fractionated radiotherapy or stereotactic radiosurgery is indicated for residual or recurrent tumors, small lesions, and tumors in challenging locations. Advances in molecular genetics and ongoing clinical trial results have recently helped both to refine the diagnosis and provide hope for effective biomolecular target-based medications for treatment. This article reviews the natural history and current therapeutic options for CNS meningiomas.
PURPOSE:To prepare the eye lotion without deteriorating the stability of vitamin A compounds by mixing a specific mixture containing vitamin A compounds with a nonionic surfactant to make the vitamins to be soluble in water and compounding the obtained mixture to an eye lotion. CONSTITUTION:This eye lotion is prepared by compounding (A) 1 pt.wt. of a vitamin A compound with (B) 6.5-10 pts.wt. of a nonionic surfactant. In the above process for the preparation of an aqueous agent, the component A or a mixture of the component A and (C) a fat-soluble vitamins other than the component A is mixed with the component B and the product soluble in water is compounded to the eye lotion. Preferably, the component B is e.g. polyoxyethylene (p=20) sorbitan monooleate and the component C is vitamin D, etc.