anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Angiopoietin-like 4 (ANGPTL4) has been identified as an adipokine involved in several non-metabolic and metabolic diseases, including angiogenesis, glucose homeostasis, and lipid metabolism. To date, the role of ANGPTL4 in cancer growth and progression, and metastasis, has been variable. Accumulating evidence suggests that proteolytic processing and posttranslational modifications of ANGPTL4 can significantly alter its function, and may contribute to the multiple and conflicting roles of ANGPTL4 in a tissue-dependent manner. With the growing interest in ANGPTL4 in cancer diagnosis and therapy, we aim to provide an up-to-date review of the implications of ANGPTL4 as a biomarker/oncogene in cancer metabolism, metastasis, and the tumor microenvironment (TME). In cancer cells, ANGPTL4 plays an important role in regulating metabolism by altering intracellular glucose, lipid, and amino acid metabolism. We also highlight the knowledge gaps and future prospect of ANGPTL4 in lymphatic metastasis and perineural invasion through various signaling pathways, underscoring its importance in cancer progression and prognosis. Through this review, a better understanding of the role of ANGPTL4 in cancer progression within the TME will provide new insights into other aspects of tumorigenesis and the potential therapeutic value of ANGPTL4. [BMB Reports 2024; 57(8): 343-351].
The invention discloses a screening method of a canine distemper virus trace neutralizing antibody. The method uses canine distemper live virus to neutralize a sample to be detected, and then inoculates the sample into vero-slam cells, and takes a fluorescent lesion as a judgment standard. The authenticity of detecting the neutralizing antibody can be ensured to the highest degree by detecting the neutralizing antibody with the true conformation of the virus. The CDV positive neutralization serum (neutralization titer is 1:708) is serially diluted into multiple concentration groups in a 2-time gradient mode to serve as samples to be detected, and the dilution degree of the method is detectedCDV neutralization activity detection rate and minimum detection limit of serum. The results show that: CDV neutralization titers were 1: serum dilution 2 of 708  12  The neutralization activity after multiplication is the lowest detection limit of the method, and the detection rate is 63.54 +/-4.774%. The method of the invention has the advantages of few used reagent varieties, no expensive reagent and low cost. The invention provides a new technical means for screening the canine distemper virus micro-neutralizing antibodies.
The routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at 1 year of biologic treatment. However, psoriasis may recur following drug withdrawal, and as a result, patients tend to continue receiving costly treatment indefinitely. Here, we review research into the "inflammatory memory" in resolved psoriasis skin and the potential mechanisms leading to psoriasis recurrence following drug withdrawal. Research has implicated immune cells such as tissue resident memory T cells, Langerhans cells, and dermal dendritic cells, and there is growing interest in keratinocytes and fibroblasts. A better understanding of the interactions between these cell populations, enabled by single cell technologies, will help to elucidate the events underpinning the shift from remission to recurrence. This may inform the development of personalized strategies for sustaining remission while reducing long-term drug burden.
OBJECTIVES: To investigate the association between trunk muscle endurance, standing balance, and neck disability in women with chronic neck pain (CNP) and to compare trunk muscle endurance and standing balance according to disability severity.
METHODS: Thirty-one women with CNP and Neck Disability Index scores of 30%-70% were included. Isometric endurance times of neck flexors, trunk flexors, extensors, and lateral flexors were measured. Overall stability index (OSI), anterior/posterior stability index (APSI), and medial/lateral stability index (MLSI) were obtained to assess standing balance under the following conditions: eyes-open on a firm surface (EO-Firm), eyes-closed on a firm surface, eyes-open on foam, and eyes-closed on foam (EC-Foam). Higher index scores indicate larger postural sway. Linear regression analysis was used for association. Participants were divided into two groups based on their disability scores, either having moderate or severe disability, and the groups were compared.
RESULTS: Trunk flexor endurance time had an effect on disability (R-squared=0.18, F(1.29)=6.453) and APSI under the EC-Foam condition (R-squared=0.17, F(1.29)=6.105) (p<0.05). Trunk extensor endurance time had an effect on OSI under the EO-Firm condition (R-squared=0.14, F(1.29)=4.775, p<0.05). Women with moderate disability had longer endurance times than those with severe disability for trunk flexors (Cohen's d=0.89, p<0.05).
CONCLUSION: Isometric endurance times of trunk flexors and extensors were associated with standing balance in women with CNP. Trunk flexor endurance was also associated with neck disability. Furthermore, women with moderate disability had better trunk flexor endurance than those with severe disability, with a large effect size.
FIELD: machining tools. SUBSTANCE: holder includes mechanism for height regulation of cutting tool center. It has tool support intended for installation of capstan of lathe or on machine mounting unit, cutting head formed with seat for cutting tool and mechanism for clamping of cutting head to support. which includes axial bore receiving tubular shank of cutting head. Clamping mechanism is found in bore and includes a pair of expanded in radial direction closing members engageable with shank of cutting head, and key entering keyway in shank. Rotation of clamping mechanism leads to change of orientation of cutting head to set the height of cutting tool center. EFFECT: higher efficiency.
BACKGROUND/AIM: Hemifacial microsomia (HFM) is the second most common congenital anomaly of the craniomaxillofacial region after the cleft lip and palate. This malformation is characterized by unilateral mandible and ear hypoplasia. Treatment varies and depends on different phenotypes. Severe deficiencies require multiple reconstructive surgeries to address facial asymmetries. This study aimed to review the surgical approach and evaluate the postoperative results of a case with right hemifacial microsomia and anotia.
CASE REPORT: This is the case of a 35-year-old female patient who, after multiple graft operations in the right mandible due to hemifacial microsomia, was operated for auricle reconstruction. Initially, a three-dimensional custom made Medpor (porex) was used, covered by the superficial temporal fascia. Subsequently, due to inflammation and partial exposure of this porous polyethylene implant (PPI), a temporalis muscular flap along with the deep temporal fascia were used as a salvage operation. Ten months later, the patient underwent deep plane face lift combined with open rhinoplasty. Lefort I osteotomies and transoral lip lengthening through a transection of the levator nasi septi muscle were also performed. Ear helix reconstruction was completed with a rotation scalp flap after tissue expansion. The patient had an uncomplicated postoperative course with an aesthetically acceptable result.
CONCLUSION: As a congenital disorder, hemifacial microsomia is present at birth and successful reconstruction is of fundamental importance for the smooth integration of these individuals into society. The multiple asymmetries, the affected topographic area of the face, as well as the onset in neonatal age constitute a challenge for reconstructive surgery.
The tablets contain 150 to 350 mg of magnesium chloride and are provided with an enteric coating. The latter is obtained by coating the MgCl2-containing tablet with a solution of cellulose acetate phthalate, castor oil, ethanol and acetone, and drying. It is possible, if appropriate, to apply an intermediate layer of polyvinylpyrrolidone. The tablets are much less sensitive to moisture than those without the enteric coating. They have no unpleasant taste and dissolve only in the intestine. They are suitable for therapeutic purposes.
OBJECTIVE: To define the reporting of Scoring Hip Osteoarthritis with MRI (SHOMRI) feature prevalence and severity, and to develop criteria to monitor feature change in longitudinal investigations.
METHODS: Twenty-five participants (50 hips) of the femoroacetabular impingement and hip osteoarthritis cohort study underwent baseline and 2-year follow-up 3 T hip MRIs. Eight hip OA features were assessed using the SHOMRI. All MRIs were read paired with knowledge of timepoint by two blinded musculoskeletal radiologists. We provide definitions to report SHOMRI feature prevalence, severity, and longitudinal change.
RESULTS: We report clear definitions for SHOMRI feature prevalence, severity, and change. When we applied the definitions to the studied cohort, we could detect the prevalence, severity, and change of hip OA features. For example, 88% of hips had labral tears (34% graded as severe tears) and 76% had cartilage defects (42% graded as full thickness). Over 70% of hips had feature change over 2 years, highlighting the sensitivity of SHOMRI definitions to assess longitudinal change of hip OA features. Intra-reader reliability was almost perfect (weighted (w)-kappa 0.86 to 1.00), with inter-reader reliability substantial to almost perfect (w-kappa 0.80 to 1.00).
CONCLUSION: This study is the first to provide definitions to report SHOMRI feature prevalence, severity, and change. The proposed definitions will enable comparison between hip MRI studies and improve our understanding of hip OA pathogenesis.
Using the techniques of the present disclosure, injectable ivermectin solutions can be safely administered to humans and animals. A macrolide cyclodextrin complex which is fully soluble or soluble in water in a ratio of at least 5 or 10mg macrolide to 1mL water. The macrolide cyclodextrin complex is nontoxic, does not use an organic solvent, and in particular embodiments is formed by the addition of a surfactant to the macrolide complex to water. In some embodiments, the macrolide cyclodextrin complex is ivermectin or an ivermectin derivative. In some embodiments of the disclosed technology, the cyclodextrin complex is 2-hydroxypropyl-beta-cyclodextrin, the surfactant may be polysorbate 80, and the weight ratio to the water is 0.01% to 25%. The water-soluble complex may be added to water. The water-soluble complex may have at least one of an antiparasitic, antiviral, and anticancer complex.
AI-061 is a co-formulation drug product (DP) consisting of 1:1 ratio mix of AI-025, an anti-PD-1 antibody, and ONC-392, an anti-CTLA-4 antibody. Both CTLA-4 and PD-1 are known targets for immunotherapy. This Phase I study will test 3 fixed doses of AI-061 given as intravenous (IV) infusion, once every 21 days (q3w): 200 mg (consists of 100 mg ONC-392 and 100 mg AI-025), 400 mg and 600 mg. The target population is patient with advanced or metastatic solid tumors that progressed on standard care systemic therapy or intolerable to standard of care systemic therapy. The primary objective is to determine the maximum toxicity dose (MTD) or the Recommended Phase 2 dose (RP2D). The study design follows the classical 3+3 design for Phase 1 study that will enroll up to 18 subjects. The treatment will be terminated when patient has intolerable toxicity, or death, or disease progression, or complete of 17 cycles of treatment in approximate 1 year, whichever come first.
Facial palsy evaluation (FPE) aims to assess facial palsy severity of patients, which plays a vital role in facial functional treatment and rehabilitation. The traditional manners of FPE are based on subjective judgment by clinicians, which may ultimately depend on individual experience. Compared with subjective and manual evaluation, objective and automated evaluation using artificial intelligence (AI) has shown great promise in improving traditional manners and recently received significant attention. The motivation of this survey paper is mainly to provide a systemic review that would guide researchers in conducting their future research work and thus make automatic FPE applicable in real-life situations. In this survey, we comprehensively review the state-of-the-art development of AI-based FPE. First, we summarize the general pipeline of FPE systems with the related background introduction. Following this pipeline, we introduce the existing public databases and give the widely used objective evaluation metrics of FPE. In addition, the preprocessing methods in FPE are described. Then, we provide an overview of selected key publications from 2008 and summarize the state-of-the-art methods of FPE that are designed based on AI techniques. Finally, we extensively discuss the current research challenges faced by FPE and provide insights about potential future directions for advancing state-of-the-art research in this field.
The cepharanthine dripping pill containing cepharanthine 1-10 mg and proper amount of dripping pill medium in each pill. The dripping pill medium is one or two of polyglycol-6000, polyglycol-4000, polyoxyethylene monostearate, sodium stearate, glycerin, gelatin, poloxamer, stearic acid, glycerin monostearate and insect wax. The preparation process of the cepharanthine dripping pill includes melting and mixing cepharanthine and dripping pill medium, dropping at 60-100 deg.c into condensating agent, and eliminating condensating agent. The condensating agent is one or two of dimethyl silicon oil, liquid paraffin, tea seed oil and rape seed oil. The cepharanthine dripping pill is white or slight yellow and bitter. The cepharanthine dripping pill is used in treating chemotherapy caused leucopenia, and has the features of less side effect, low dosage, high medicinal effect, etc.
The invention relates to a surface guanidino modified nano adjuvant material and a preparation method and application thereof, and the material comprises polyethylene glycol- b Polycaprolactone- g Poly (guanidino-ethyl-methacrylate), wherein ε ‑CL( ε Caprolactone with BMPCL (C: (C) γ - (2-bromo-2-methylpropionate) - ε -caprolactone) with a degree of polymerization ranging from 30 to 35 and from 3 to 3.5, respectively, and guanidino-ethyl-methacrylate with a degree of polymerization ranging from 3 to 105. The nano adjuvant is formed by self-assembly of triblock copolymers. And mixing the antigen and the nano adjuvant to obtain the nano vaccine system. The polymer nano adjuvant has good stability and stronger immunogenicity, and can effectively promote the uptake and cross presentation of antigens by antigen presenting cells such as dendritic cells and the like. The in vivo immunization of the nano vaccine can obviously improve the humoral and cellular immune response of antigen specificity. The synthesis and nano vaccine preparation method of the invention is simple, simple and convenient to operate, good in repeatability and suitable for large-scale production.
Single-arm study of AB-16B5 given as a 60-minute intravenous weekly infusion. One cycle of treatment will consist of 21 days. The dose levels that will be assessed are 1.5, 3.0, 6.0, 9.0 and 12 mg/kg.
BACKGROUND: The objective of this study was to evaluate the stiffness of the anterior talo-fibular ligament (ATFL) and calcaneo-fibular ligament (CFL) using shear wave elastography (SWE) with the ankle in the neutral position and in varus, in young healthy adult volunteers. We also evaluated the reliability and reproducibility of the SWE measurements.
HYPOTHESIS: The stiffness of both ligaments increases with increasing ankle varus. SWE may be a reliable tool for evaluating the lateral collateral ligament complex of the ankle.
MATERIAL AND METHODS: We used SWE to evaluate both ankles of each of 20 healthy volunteers (10 females and 10 males). For each test, the foot was placed on a hinged plate and tested in the neutral position and in 15° and 30° of varus. Stiffness was evaluated based on shear wave velocity (SWV).
RESULTS: Stiffness of both the ATFL and CFL was minimal in the neutral position (2.06m/s and 3.43m/s, respectively). Stiffness increased significantly for both ligaments in 15° of varus (2.48m/s and 4.11m/s, respectively; p<0.0001) and was greatest in 30° of varus (3.15m/s and 4.57m/s, respectively; p<0.0001). ATFL stiffness was greater in males than in females in 15° (p=0.04) and 30° (p=0.02) of varus. For the CFL, in contrast, stiffness was not different between males and females. Stiffness of the ATFL and CFL was not associated with age, dominant side, height, or foot morphology. No correlations were found between stiffness of the two ligaments in any of the positions. Repeating each measurement three times produced excellent concordance for both ligaments in all three positions.
CONCLUSION: The ATFL and CFL are the main lateral stabilisers of the ankle, and each exerts a specific function. Their stiffness increases with the degree of varus. This study describes a protocol for evaluating ATFL and CFL density by SWE, which is a reliable and reproducible technique that provides a normal range.
LEVEL OF EVIDENCE: IV.
Subjects will be randomized to receive dabrafenib plus panitumumab. Dose levels for dabrafenib, and panitumumab in Part 3 will be chosen based on emerging PK, PD, and tolerability data from Part 1 and Part 2.
Participants will complete the 8-module intervention of Acceptance-enhanced behavior therapy (AEBT) and will receive weekly check-ins. Acceptance-enhanced behavior therapy is a manualized treatment approach created by Woods and Twohig 2008 that provides both Acceptance and Commitment Therapy and Habit Reversal Therapy.
The invention relates to a method for preparing a nanometer traditional Chinese medicine for treating severe asthma and a production method thereof. The nanometer traditional Chinese medicine comprises the following raw materials in part by weight: 10 to 20 parts of radish seed, 10 to 20 parts of shizandra berry, 15 to 30 parts of malaytea scurfpea, 6 to 12 parts of common threewingnut root and the like. The production process comprises the following steps of: ultrasonic extracting, microwave extracting, supersonic crushing, nanometer grinding, mixing, filling and the like. In the method, the nanometer traditional Chinese medicine has the synergetic and multi-targeting effects of nanometer medicaments. Products have the effects of concurrent treatment of lung, spleen, kidney and liver, tonification and purgation in combination and the like by treatment methods of warming yang, keeping strong and healthy, replenishing qi to invigorate spleen, warming lung to eliminate cold, resolving sputum, relieving asthma, dispelling dampness, resolving sputum, tonifying kidney, holding qi and the like. The nanometer traditional Chinese medicine has good effect of treating the severe asthma, can enhance the immunity in human bodies and does not have toxic or side effects.
All participants were monitored for a one week baseline period to establish their habitual physical activity and dietary patterns. This was done using food diaries, interstitial glucose monitors and a combined heart rate + accelerometer device. Participants consumed a standardised evening meal \~12h before visiting the laboratory to assess their metabolic response to a liquid test meal (1g/kg bodyweight dextrose and 0.4g/kg bodyweight protein) using the arterio-venous forearm balance model. Dual-energy X-ray absorptiometry scans, indirect calorimetry measurements and fasted and postprandial vastus lateralis biopsies were also obtained.

From the next day, participants either restricted their daily energy intake window to between 8 am and 4 pm or were prescribed a caloric deficit diet (\~400 kilocalories/day) for two weeks. Physical activity, interstitial glucose concentrations and dietary patterns were monitored throughout. After this, participants visited the laboratory again to assess changes in metabolism and body composition.
Sterile aluminium hydroxide suspension for subcutaneous injection were applied in the upper arm. Vials with strength A contained 0.0125 mg/mL and with strength B 0.125 mg/mL histamine-dihydrochloride and strength 0 was produced by dilution of strength A. The vials containing the placebo solution were identical in their outer appearance with the active study preparation of the birch pollen allergoids.
To investigate risk factors for re-infection and compare the outcomes in people with diabetic foot infections. A retrospective chart review was conducted, and 294 hospitalised patients with moderate to severe diabetic foot infections (DFIs) were analysed for this study. The diagnosis and classification of the severity of infection was based on the International Working Group on the Diabetic Foot (IWGDF) infection guidelines. Skin and soft tissue infections were diagnosed based on clinical observations as per IWGDF classification in addition to ruling out any suspected osteomyelitis (OM) through negative bone culture, MRI or WBC SPECT CT. OM was confirmed by bone culture or histopathology. Clinical outcomes were based on a 12-month follow-up period. All dichotomous outcomes were compared using χ2 with an alpha of 0.05. The result of this study shows a 48% rate of re-infection in people admitted to our hospital with moderate and severe diabetic foot infections (DFI). Patients with osteomyelitis present during the index admission were 2.1 times more likely to experience a re-infection than patients with soft tissue infection (56.7% vs. 38.0% respectively). In the univariate analysis, risk factors for re-infection included osteomyelitis, non-healing wounds, prolonged wound healing, antidepressants and leukocytosis. In the regression analysis, the only risk factor for re-infection was wounds that were not healed >90 days (HR =2.0, CI: 1.5, 2.7, p = 0.001). Re-infection is very common in patients with moderate and severe diabetic foot infections. Risk factors include osteomyelitis, non-healing wound, prolonged wound healing, antidepressants and leukocytosis.
The control group receives no application for use. They need to finish the onboarding survey, donate their food purchase data and finish the post-study survey (voluntary). They receive no intervention while the experimental group should be actively using the FoodCoach app. The investigators will send them an analysis report of their food purchase data via email in 3 months after the intervention phase is gone. Note the intervention lasts for 9 weeks.
The invention discloses an active substance composition, a preparation method therefor, preparations thereof, and applications thereof. The active substance composition is prepared from the following raw materials: by weight, 1-90% of poria cocos, 1-90% of lucid ganoderma, 1-90% of dendrobe, the balance being macro fungi after extraction. The preparation method for the active substance composition comprises steps of material preparation, extraction, condensation, desiccation and inspection, and concretely comprises steps: raw materials are extracted respectively, desiccated, crushed, mixed uniformly, crushed, sieved through an 80-mesh sieve, disinfected, packaged, and inspected by sampling, and reports are provided. The preparations are composed of the active substance composition and acceptable auxiliary materials in pharmaceutical field, and can be powders, tablets, granules, capsules and pills. The active substance composition can be applied to preparation of antineoplastic drugs. The active substance composition is prepared from nuisanceless medicinal materials. Functional components of medicinal materials are retained to the extreme in process of preparation. The preparation method is advantaged by simple technology, environmental protection, safety and low cost. The active substance composition is advantaged by high bioavailability and can give full play to functional components of medicinal materials.