anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A cosmetic composition contains a dispersion, in a fatty binder, of a particulate filler composed of solid particles of at least one material compatible with application to the skin. The particulate filler contains at least 50 wt. %, or at least 75 vol. % relative to the total particulate filler, of spherical or spheroidal particles 0.5 to 50 μ in size. The particulate filler has an oil uptake such that its concentration by volume C*, when the volume of binder is equal to that of the oil uptake (measured on the nonvolatile fraction of the binder), is between 3 and 90%. The concentration by volume of the particulate filler in the dispersion, measured on the nonvolatile fraction of the binder, namely without taking into account any volatile oils that may be present in the fatty binder, is at least equal to C* and preferably greater than C*. This composition allows skin defects (color differences and micro reliefs) to be blurred while leaving a translucent layer on said skin.
Disclosed are system for and method for managing electronic medical records in a computing environment. These aspects of the present invention are computer-executable and implementable and may be utilized in a permission-based system for managing electronic medical records utilizing a set of computer-executable software application services in an electronic computing environment. The system is adapted for keeping, sharing, enumeration, development of the electronic medical records, and gathering of statistical data sets for the same electronic medical records without any risk of breaching privacy of a patient. In one aspect, the method utilizes statistical data sets characterized by pluralities of medical data that are enumerated during data generation by one or more medical data generation sources before the medical data are attributed to the patient. Further, possessorship of the medical data is preferably segregated from a medical service provider to which the medical data are to be posted for analysis and diagnostic purposes. These provisions protect the privacy vulnerabilities in data streams.
BACKGROUND: Epidemiological evidence on weight change and atrial fibrillation (AF) remains limited and inconsistent. Previous studies on body mass index (BMI) in youth and AF rarely considered subsequent BMI. This study aimed to assess the associations of AF with weight change and BMI in youth, as well as modified effect by genetic susceptibility of AF.
METHODS: The study included 21,761 individuals (mean age 57.8 years) from the Malmö Diet and Cancer cohort. Weight information was obtained at three time points, including recalled weight at age 20 years, measured weight at baseline (middle adulthood), and reported weight at 5-year follow-up examination (late middle adulthood). A weighted genetic risk score of AF was created using 134 variants.
RESULTS: During a median follow-up of 23.2 years, a total of 4038 participants developed AF. The association between weight change from early to middle adulthood and AF risk was modified by sex (Pinteraction = 0.004); weight loss was associated with a lower AF risk in females, but not in males. Conversely, weight gain was positively associated with AF risk in a linear manner in females, whereas increased AF risk appeared only when weight gain exceeded a threshold in males. Participants with weight gain of > 5 kg from middle to late middle adulthood had a 19% higher risk of AF relative to those with stable weight, whereas weight loss showed a null association. Compared to individuals with a lower BMI at age 20 years, those with a BMI above 25 kg/m2 had an increased risk of AF (HR = 1.14; 95% CI: 1.02-1.28), after controlling for baseline BMI; this association was more pronounced in males or those with a lower genetic risk of AF.
CONCLUSIONS: Weight gain in middle adulthood was associated with higher AF risk. Weight loss from early to middle adulthood, but not from middle to late middle adulthood, was associated with a lower risk of AF only in females. Higher BMI in youth was associated with an increased risk of AF, particularly among males or those with a lower genetic risk of AF.
INTRODUCTION: Distal radioulnar joint (DRUJ) instabilities are challenging and their optimal treatment is controversial. In special cases or when reconstruction of the stabilizing triangular fibrocartilage complex (TFCC) fails, K-wire transfixation can be performed. However, no consensus has been reached regarding the rotational position of the forearm in which this should be done. Therefore, it was investigated whether anatomical reduction would best be achieved by transfixation in neutral position or supination of the forearm.
MATERIALS AND METHODS: Twelve cadaveric upper limbs were examined before dissection of the DRUJ stabilizing ligaments and after closed transfixation in both positions by C-arm cone-beam CT. Whether this was first done in neutral position or in supination was randomized. The change in the radioulnar ratio (RR) in percentage points (%points) was analyzed using Student's t-test. RR was used since it is a common and sensitive method to evaluate DRUJ reduction, expressing the ulnar head's position in the sigmoid notch as a length ratio.
RESULTS: The analysis showed an increased change in RR in neutral position with 5.4 ± 9.7%points compared to fixation in supination with 0.2 ± 16.1%points, yet this was not statistically significant (p = 0.404).
CONCLUSIONS: Neither position leads to a superior reduction in general. However, the result was slightly closer to the anatomical position in supination. Thus, transfixation of the DRUJ should be performed in the position in which reduction could best be achieved and based on these data, that tends to be in supination. Further studies are necessary to validate these findings and to identify influential factors.
An input genotype is divided into a plurality of windows, each including a sequence of SNPs. For each window, a diploid HMM is computed based on genotypes and/or phased haplotypes to determine a probability of a haplotype sequence being associated with a particular label. For example, the diploid HMM for a window is used to determine the emission probability that the window corresponds to a set of labels. An inter-window HMM, with a set of states for each window, is computed. Labels are assigned to the input genotype based on the inter-window HMM. Upper and lower bounds are estimated to produce a range of likely percentage values an input can be assigned to a given label. Confidence values are determined indicating a likelihood that an individual inherits DNA from a certain population. Maps are generated with polygons representing regions where a measure of ethnicity of population falls within specific ranges.
PURPOSE:To provide a water-based enteric coating agent free from salts, having high handleability, dispersibility and safety, by dissolving a carboxyl-containing polymer in a specific lower alcohol, and adding water to the solution to obtain a dispersion. CONSTITUTION:A carboxyl-containing polymer soluble in 1-3C lower alcohol (e.g. carboxymethylcellulose, carboxyethyl ethylcellulose, etc.) is dissolved in 50-100wt% of a 1-3C lower alcohol which may contain <=wt% of water, or a mixture of the above alcohols, and the solution is added with water to obtain the titled coating agent in the form of a dispersion. The concentration of the polymer is preferably 20-40wt%. The lower alcohol is principally ethyl alcohol from the viewpoint of safety. It has excellent handleability, dispersibility, yield, and safety compared with conventional water-based enteric coating agent.
Positive control. Single 400 mg dose of celecoxib administered orally, open label, on one occasion separated by at least a 3 week washout period.
There are disclosed ophthalmic compositions having high water-binding properties which are useful as: moisturizing and lubricating (i.e. artificial tear) solutions, dry eye therapies, contact lens wetting and lubricating solutions, and as delivery vehicles for ophthalmic drugs. The subject compositions include glycerin in combination with propylene glycol. The subject compositions may further include cellulose derivatives, e.g. hydroxypropyl methyl cellulose, along with preservatives, e.g. benzylalkonium chloride, PHMB, sorbic acid, etc. Preferred compositions have at least 11% bound water, a pH from about 7.1 to 7.5, and an osmolality between about 280 to about 320 mOsm/Kg.
Pilates exercises developed by Joseph Pilates has an increasing popularity in last decades. Pilates supposed that the balance between body and mind is an important factor in achieving health and happiness. Pilates stimulates the mind and decreases mental strain. The basic principles of Pilates-based approach are concentration, control, centering, diaphragmatic breathing, lightness, precision, and relaxation. It also aims to enlighten the awareness of body by inducing mind control. The control of large group muscles with coordination and focusing on breathing may increase aerobic capacity, and further improves mental health. Heretofore, some researchers also reported that the holistic approach of Pilates-based training may provide physical and psychological improvements on human health, and various intensities benefit the quality of life, mental health, physical fitness levels, and body types. Pilates exercises are utilized with a wide range spectrum for many diseases' management and are particularly used also for mental health disease such as depression, anxiety, mood etc. The sample of the study consisted of patients who were diagnosed with schizophrenia according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Current study was conducted in accordance with the Helsinki Declaration and its subsequent amendments. All the subjects volunteered to participate in this research and signed the informed consent form approved by the Institutional Clinical Research Ethics Committee (Protocol no: 2015-84-21/10). On receipt of a completed consent form, patients were assigned to Pilates exercise group (PEG) or control group (CG) based on their willingness.
Osteoporosis is responsible for more than 1.5 million fractures and $14 billion in medical care costs annually (U.S Dept of Health and Human Services data, 2006). Down syndrome is an independent risk factor for osteopenia/osteoporosis. Increases in life expectancy as well as costly morbidity following fracture are reasons for further investigation of osteoporosis and prevention in this population. Etiology for low bone density is presently unknown in this population but may be related to unique genes on chromosome 21 which alter the biochemistry of bone metabolism or change the gonadal, thyroid and parathyroid function to alter bone formation and/or resorption. There are no published data on the measurement of bone turnover markers in the Down syndrome population; therefore we will measure and accrue this information and compare to our Ts65Dn data, as described later in this protocol.

This pilot study will serve as the foundation for a larger translational research grant which will address multiple issues regarding the pathogenesis, diagnosis and treatment of osteoporosis in the Down syndrome patient population and the Down syndrome mouse model (Ts65Dn). The data has the potential to improve our fundamental understanding of osteoporosis pathogenesis and treatment in the Down syndrome patient with potential applications to treatment in the general population.
301,479. Fredriksson, P. E., and Blomberg, A. R. Dec. 1, 1927, [Convention date]. Void [Published under Sect. 91 of the Acts]. Light and other radiations, treating diseases with.-In radioactive compresses, bandages and the like, the radioactive substance, in finely divided state, is distributed throughout a fibrous carrier the fibres of which hold the substance and prevent the collection thereof into lumps- The fibrous substance mav be a wad of cotton wool in which case the wad is usually split lengthwise and the two halves reunited by pressure after radioactive substance has been distributed upon the inner sides of one or both halves, accompanied, if desired, by shaking or beating. The wad may be coated externally with glue or other adhesive through which, if not too dense, the radioactive substance may be introduced. The impregnated wad is enclosed in a covering of cloth leather or the like, or if no glue &c. coating is provided, of oil-skin attached by sewing- Instead of cotton wool a wad of cloth of loose texture or formed with a fluffy nap as by teasing may be employed.
This study is a prospective, randomized, controlled (randomized, parallel group, concealed allocation), double-blinded trial. All patients undergoing heart valve surgery with cardiopulmonary bypass will be randomized 1:1 to the treatment intervention with lithium carbonate 250mg (Baoqing, Hunan, China) or calcium carbonate 500mg (Reneed, Beijing, China) after surgery. The objective of the trial is to evaluate the lithium carbonate 250mg on the postoperative night sleep quality. Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00. Mini-Mental State Examination (MMSE) score was performed on the seventh postoperative day
A spherical core containing an esomeprazole compound as an active ingredient and having a median particle diameter (d 50 ) of 50 μm or more is coated with a coat containing a controlled release layer to prepare a controlled release granule containing a controlled release granule with a median particle diameter (d 50 ) of 350 μm or less. The spherical core may contain the esomeprazole compound at a proportion of 50% by mass or more relative to the spherical core. The spherical core may be a spherical particle containing the esomeprazole compound as a drug. The spherical core has a median particle diameter (d 50 ) of 50 μm or more. The spherical core may have a sphericity of 0.6 or more. The coat may be in a multilayer free from an esomeprazole compound as an active ingredient. The controlled release layer may be an enteric coating layer. The proportion of the coat may be 80% by mass or more relative to the whole amount of the preparation. The oral preparation may be an orally disintegrating tablet containing a disintegrator in addition to the controlled release granule. The oral preparation has an excellent controlled release ability and an excellent formulation designability such as miniaturization.
Health simulation is in full development on the national territory (France). The medical profession and nurses use this mode of learning in initial training to improve the students skills The report of Pr Granry allowed an inventory of the simulation in France with as Leitmotiv "never the first time for the patient". It has also put in place priorities for the coming years, one of which is to develop simulation in initial and in-service training. This learning technique is interesting according to several parameters. First,is the safety of care. A novice who has already practiced on a mannequin or in the context of the simulation will be able to better understand the situation of care in the clinical field. The quality of care is also improved by the practice of simulation including communication skills, psychomotor skills, respect for procedures and theoretical knowledge. This more or less faithful reproduction is all the more necessary as the duration of clinical placements is decreasing. Simulation is a way to mitigate this lack is allows a faithful immersion in the care environment. Despite all these positive points, physiotherapy is not yet very affected by the simulation as shown in the literature Gordon's review (2015). Initial training, continuing education has not to this day largely developed this teaching method . Some timid uses have taken place and for the most part in Anglo-Saxon countries with various modes of simulation. In France, certainly linked to the specificity of the profession, its implementation is delicate, even complicated. It remains anecdotal to this day.
The role of colchicine for the prevention of postoperative atrial fibrillation (POAF) after cardiothoracic surgery is not well-established. We aimed to evaluate its potential in preventing POAF using data from randomized controlled trials (RCTs). A literature search was performed to identify studies reporting POAF as an outcome after cardiac or thoracic surgery in adult patients randomized to either colchicine or placebo. Primary outcome measured was incidence of POAF. Secondary outcomes included gastrointestinal (GI) adverse effects, sepsis, and length of stay. Subgroup analyses based on treatment durations and type of surgery were also performed, as well as regression analyses to control for covariates. We identified a total of 5377 patients (colchicine = 2,689, placebo = 2688). Although colchicine use was associated with a significantly reduced risk of POAF, risk of GI adverse effects were significantly higher. The rates of infection and length of stay were similar across the groups. Subgroup analyses showed that colchicine was effective for POAF prevention in cardiac surgery, but not in thoracic surgery. Prevention of POAF and incidence of GI adverse effects were similar in short-term and long-term colchicine treatment. Colchicine significantly reduces the incidence of POAF in patients undergoing cardiac surgery, but not in thoracic surgery.
A â2-adrenergic receptor agonist compound of formula II and its salts, wherein: Ar1 and Ar3 are aryl, heteroaryl or heterocyclyl; Ar2 is (a) phenylene, wherein W and X are attached at the 1,2-, 1,3- or 1,4-position of the ring; (b) cyclohexylene optionally substituted with methyl, wherein W and X are attached at the 1,3- or 1,4-position of the cyclohexylene ring; and (c) piperazinylene, wherein W and X are attached at the 1,4-positions of the piperazinylene ring; Q is -NHCH2CH(OH)-; W is alkylene or substituted alkylene; and X is a covalent bond. â2-adrenergic receptor agonists are multi-binding compounds of formula II that bind endothelin receptors are used to treat disorders affecting the cardiovascular, renal, endocrine and nervous systems in mammals that are mediated by the endothelin receptors, such as congestive heart failure, pulmonary hypertension, cerebral vasospasm following subarachnoid hemorrhage, essential hypertension, myocardial infarction, myocardial ischemia, unstable angina, restenosis, renal failure of ischemic origin, portal hypertension, cardiac hypertrophy, atherosclerosis, eclampsia, cerebrovascular disease, vascular disease, migraines, and auto-immune diseases, such as Morbus Wegener and Morbus Raynaud, to name a few.  These multi-binding compounds (â2-adrenergic receptor agonists) comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof.  Each of the ligands, which may be the same or different, is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound.  The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the endothelin receptor than that provided by the ligands in monomeric form.  The specification also discloses pharmaceutical compositions comprising the multi-binding compounds, methods of inhibiting and treating the disorders mediated by endothelin receptors, and methods of preparing these multi-binding compounds.
The present invention relates to the cationic lipid cordiaroimide hybrid compounds of formula I. The present invention provides a process for preparation of these compounds is also being elaborated. The compounds described provides anticancerous activity against cell lines including PC-3 (prostate cancer), HepG2 (liver cancer), MCF-7 (breast cancer) and NIH-1/3T3 (non cancer cells. The compound was also capable of inducing caspase-3 mediated apoptosis in HepG2 cells by arresting the cell cycle in the G1 phase. Furthermore, the compound exhibited DNA ligase I inhibition. The present class of cationic lipid cordiarimide hybrids is likely to find specific use in developing novel targeted therapies for liver and prostate cancers.
Fabrics act as fomites for microorganisms, thereby playing a significant role in infection transmission, especially in the healthcare and hospitality sectors. This study aimed to examine the biofilm formation ability of four nosocomial infection-causing bacteria (Acinetobacter calcoaceticus, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) on cotton, polyester, polyester-cotton blend, silk, wool, viscose, and nylon, used frequently in the healthcare sector, by qualitative and quantitative methods. The impact of temperature, pH, and relative humidity (RH) on biofilm formation was also assessed. P. aeruginosa and S. aureus were strong biofilm producers, while E. coli produced weak biofilm. Wool (maximum roughness) showed the highest bacterial load, while silk (lowest roughness) showed the least. P. aeruginosa exhibited a higher load on all fabrics, than other test bacteria. Extracellular polymeric substances were characterized by infrared spectroscopy. Roughness of biofilms was assessed by atomic force microscopy. For biofilm formation, optimum temperature, pH, and RH were 30 °C, 7.0, and 62%, respectively. MgCl2 and CaCl2 were the most effective in removing bacterial biofilm. In conclusion, biofilm formation was observed to be influenced by the type of fabric, bacteria, and environmental conditions. Implementing recommended guidelines for the effective disinfection of fabrics is crucial to curb the risk of nosocomial infections. In addition, designing modified healthcare fabrics that inhibit pathogen load could be an effective method to mitigate the transmission of infections.
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).

Using data from GPRD, MINAP, ONS mortality data and Hospital Episode Statistics (HES), this study will identify patients with a first MI (STEMI and non-STEMI). Information from in-patient hospital visits, general practice data and self-reported data in MINAP, this study will allow the quantification of the level and timing of cardiovascular disease before first MI. It will also measure the levels of cardiovascular risk factors and chest pain occurring before MI.
Chronic pain is poorly explained by the pathological biomechanical model. Pain neuroscience education (PNE) aims to help patients reconceptualize their pain by understanding its physiology and dissociating it from the notion of threat. It must be combined with functional re-education. Catastrophism and kinesiophobia exacerbate the perception of pain and are an obstacle to movement. Gradual exposure to movement, whether virtual or real, is a tool for managing pain more effectively and regaining optimum functionality. According to the literature, PNE reduces pain intensity, catastrophizing, kinesiophobia, disability and improves functionality.