anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Results from studies of older long-acting injectable antipsychotics (not risperidone) show that patients tend to relapse (which means start having symptoms again) when they are given low doses. However, increasing the dose may cause more side effects. This study will measure the time to relapse during a 52-week period in patients with schizophrenia or schizoaffective disorder who are switched from an oral antipsychotic (one taken by mouth) to one of two doses of long-acting risperidone injections (shots). The patients will be assigned to a dose of either 25 or 50 milligrams per injection every 2 weeks. Patients continue to take their usual oral antipsychotic medications up to 3 weeks following the first injection. After this 3-week period, they will receive the injectable risperidone only. Patients will be asked questions at each visit to help determine the effectiveness of the drug as assessed by the Clinical Global Impression Scale and the Positive and Negative Syndrome Scale. The safety of the drug will be based on patient signs and symptoms assessed according to the Extrapyramidal Symptom Rating Scale and self-reported treatment-emergent adverse events. Long-acting risperidone injection, 25 or 50 milligrams per injection, every 2 weeks for 52 weeks. Patients will continue to take their current oral antipsychotics for up to 3 weeks following the first injection of risperidone.
Comorbidity is a well established aspect of adolescent psychopathology. The majority of adolescents entering treatment have more than one condition. This study will evaluate service delivery methods of integrating empirically supported interventions for depression and non-nicotine substance use disorders (SUD)in an effort to improve treatment engagement, response, and maintenance of gains. The two examined interventions are the Adolescent Coping With Depression course (ACWD) and Functional Family Therapy (FFT).

This study will expand upon previous research by systematically treating both depression and SUD. Over a 5 year period, 180 adolescents with depression/SUD and their parents/guardians will be recruited in Oregon and New Mexico and randomly assigned to 1 of 3 conditions: (a) FFT followed by ACWD, (b) ACWD followed by FFT, or (c) an intervention combining and augmenting FFT and ACWD (Integrated Treatment). Each treatment arm will consist of 24 sessions provided over 20 weeks. Participants will be assessed at intake, after the provision of 6, 12 (Mid-treatment), 18 and 24 (Post-treatment)treatment sessions, and at 6 and 12 month follow-ups.
The present invention provides novel dental care products comprising self-assembling peptides capable of self-assembling at a specific pH, useful for dental care, in particular useful for reducing or preventing demineralization of a subject's teeth, in particular useful for reducing or preventing further demineralization of a subject's teeth. The dental care product comprises a self-assembling peptide, in particular a self-assembling peptide comprising the sequence of SEQ ID NO:21, which is capable of self-assembling at a pH below 7.5, and a pharmaceutically acceptable matrix, wherein the self-assembling peptide is substantially present in the dental care product in assembled form. The dental care product is a substantially solid product selected from the group consisting of chewing gum, soft chewy candy, toffee, gummy candy, chewy candy, chew toys, lozenges. Preferably, it is a chewy product. The present dental care products are not abrasive. The dental care product may be used to reduce or prevent/further prevent demineralization of tooth surfaces in subjects having, for example, demineralized teeth, or subjects having xerostomia, hyposalivation, bruxism, gastroesophageal reflux disease, dentinal hypersensitivity and/or dental erosion. Preferably, it can also be used to clean tooth surfaces. The products of the invention are useful for animals and humans. The present invention also provides methods of making the dental care products of the present invention. The invention enables non-targeted treatment of multiple teeth and is independent of caries diagnosis.
OBJECTIVES: Sleep difficulties are associated with many physical and mental health problems, such as diabetes, hypertension, and depressive symptoms. Sleep can be affected by stressors such as discrimination and stigma, which are disproportionately experienced by sexual and gender minority (SGM) individuals. This research assesses how different characteristics, including discrimination and stigma, sociodemographic characteristics, community connectedness, self-rated good health, and outness levels, influence a sleep disorder diagnosis among SGMs.
METHODS: We analyzed data from wave 3 of Generations: A Study of the Life and Health of LGB People in a Changing Society. We used bivariate analysis to document the distribution of key variables across SGM status. Next, we conducted logistic regression analyses to measure how each variable influences the likelihood of an SGM individual being diagnosed with a sleep disorder considering experiences of discrimination and stigma.
RESULTS: We found that feeling stigma was statistically significant in predicting a sleep disorder diagnosis among SGM individuals. However, after controlling for sociodemographic characteristics, community connectedness, self-rated good health, and outness levels, SGM individuals only had increased odds of a sleep disorder diagnosis if they reported higher scores on the Internalized Homophobia Scale.
CONCLUSIONS: Variation in having a sleep disorder diagnosis differs based on SGM status and could not be explained away with the inclusion of all covariates. Our findings support the need for more research to compare health outcomes between different sexual and gender identities, rather than comparing them with their nonminority counterparts.
Short Title: Benzimidazoisoquinoline derivatives as potent antifibrotics Hepatic fibrosis is a pathological condition of liver disease with an increasing number of cases worldwide. Therapeutic strategies are warranted to target the activated hepatic stellate cells (HSCs), the collagen-producing cells, an effective strategy for controlling the disease progression. Benzimidazoisoquinoline derivatives were synthesized as hybrid molecules by the combination of benzimidazoles and isoquinolines to evaluate their anti-fibrotic potential using an in-vitro and in-vivo model of hepatic fibrosis. A small library of benzimidazoisoquinoline derivatives (1-17 and 18-21) was synthesized from 2-aryl benzimidazole and acetylene functionalities through C-H and N-H activation. Compounds (10 and its recently synthesized derivatives 18-21) depicted a significant decrease in PDGF-BB and/or TGFβ-induced proliferation (1.7-1.9 -fold), migration (3.5-5.0 -fold), and fibrosis-related gene expressions in HSCs. These compounds could revert the hepatic damage caused by chronic exposure to hepatotoxicants, ethanol, and/or carbon tetrachloride as evident from the histological, biochemical, and molecular analysis. Anti-fibrotic effect of the compounds was supported by the decrease in the malondialdehyde level, collagen deposition, and gene expression levels of fibrosis-related markers such as α-SMA, COL1α1, PDGFRβ, and TGFRIIβ in the preclinical models of hepatic fibrosis. In conclusion, the synthesized benzimidazoisoquinoline derivatives (compounds 18, 19, 20, and 21) possess anti-fibrotic therapeutic potential against liver fibrosis.
Combination Product: Placebo The placebo medical gas consists of 30% oxygen and 70% nitrogen. The dose of placebo medical gas is 10 L by volume.
The invention discloses a polyp image semantic segmentation method and device. The device comprises an acquisition module, a segmentation module and a display module. The using method comprises the following steps: the acquisition module acquires enteroscopy video and converts the enteroscopy video into image frames. The segmentation module pre-processes the converted image to remove the reflective part, then inputs an Ext-HarDNet network consisting of an encoder, a middle layer and a decoder, discards the shallow features of the image, extracts the attention features corresponding to the deep features, and performs bilinear sampling after feature fusion. The obtained segmentation result is displayed by a display module. The method can overcome the problems of picture compression and module caused by a main stream anti-reflection method, and a backbone network is constructed by using a low-flow HarDNet frame, so that the speed can be improved, and the real-time performance is met. The middle layer may strengthen the global feature association. The fusion method of the decoder can improve the proportion of the effective receptive field. And finally, accurate and rapid segmentation of the polyp image is realized.
Low grade gliomas are brain tumors with usually poorly defined borders between tumor and normal brain. This characteristic of low grade gliomas makes the gross total resection of the tumor extremely difficult. Nevertheless, several studies have demonstrated that the risk of recurrence and progression into a more malignant tumor can be decreased with a more aggressive surgical resection. An aggressive attempt to achieve a gross total resection may result in the resection of normal brain and therefore neurological injury. For this reason, the more common error is to subtotally resect the tumor leaving significant volumes of tumor behind. Many techniques have been introduced to safely increase the extent of resection, since the extent of resection is associated with a higher survival rate. Each one of these techniques has several shortcomings. The current study will assess whether the intraoperative stereotactic injection of the indigo carmine at the tumor margins helps to safely increase of extent of tumor resection. In the first step of the study the safety and the correlation between resection of stained tissue/extend of tumor resection will be assessed. If the results are satisfactory, then the second step will ensue. In the second step we will assess the utility of indigo carmine as an additional adjunct to guide tumor resection.
Idiopathic carpal tunnel syndrome is the most common entrapment neuropathy in hand surgery, and it is characterized by Noninflammatory fibrosis of subsynovial connective tissues. The prevalence and incidence differ between male and female individuals, and the mechanism underlying this difference remains largely unclear. In the present study, we collected subsynovial connective tissues from six male and six female patients diagnosed with idiopathic carpal tunnel syndrome during surgery. We performed a comprehensive gene expression analysis using RNA sequencing to compare the gene expression profiles between male and female patients with idiopathic carpal tunnel syndrome. We identified 26 genes with significantly different expressions between male and female patients, in which POSTN, COL1A1, and COL3A1, which are involved in extracellular matrix organization, and IGF1, an important fibrotic factor, were significantly upregulated in male patients. Immunohistochemistry confirmed the expression of proteins encoded by these genes in tissues, and male patients tended to show increased POSTN expression. Our results indicate that fibrosis of subsynovial connective tissues is induced by different mechanisms in male and female patients, and genes involved in extracellular matrix organization, especially POSTN, might be important factors in male patients. This study provides insight into the pathogenesis of idiopathic carpal syndrome and might contribute to the development of new treatment strategies.
The production of silicon porous particles for the application of active substances, comprises doping an area (2) of a p-doped silicon wafer (1), producing recesses (3) in the silicon wafer, porosifying of the silicon wafer, functionalizing of the porous particles, and removing of the porous particles by mechanical effect. An area enclosed by the recesses forms the lateral dimensions of the porous particle. The area that is near to a surface is doped with a layer thickness of 500 nm to 5 mu m. Stabilizing elements are present in the structure of recesses. The production of silicon porous particles for the application of active substances, comprises doping an area (2) of a p-doped silicon wafer (1), producing recesses (3) in the silicon wafer, porosifying of the silicon wafer, functionalizing of the porous particles, and removing of the porous particles by mechanical effect. An area enclosed by the recesses forms the lateral dimensions of the porous particle. The area that is near to a surface is doped with a layer thickness of 500 nm to 5 mu m. Stabilizing elements are present in the structure of recesses. Below the doped area forming the porous particle, an area with higher porosity or area with local electro polishing is formed opposite to the doped area. Non-porosified area is formed below the porous particle formed in the doped area. An independent claim is included for silicon porous particles.
The interventions were conducted for 6-week training phase and 6-week maintenance phase. Including cognitive training, physical exercise, healthy lifestyle education, and computerized interaction training. The multimodal intervention program included the in-person training course (90-minute, once per week for 6 weeks), computerized interaction training (30-minute, 3 times per week for 6 weeks), and homework (30-minute, every day for 12 weeks).
The application provides a polypeptide for promoting a swine organism to generate african swine fever virus antigen specific immune response and application thereof, belonging to the technical field of biological medicine; the polypeptide comprises one or more of a first polypeptide, a second polypeptide, a third polypeptide, a fourth polypeptide and a fifth polypeptide; the amino acid sequences of the first polypeptide, the second polypeptide, the third polypeptide, the fourth polypeptide and the fifth polypeptide are respectively shown as SEQ ID NO. 1-SEQ ID NO. 5. The polypeptide can obviously promote proliferation of ASFV sensitized immune cells, and can promote the pig organism to generate an ASFV antigen-specific immune response by promoting secretion of IFN-gamma by pig mononuclear macrophages and B, T lymphocytes. After the animals are immunized, the immune response of the pig organism can be obviously promoted. The polypeptide or the polypeptide polymer obtained by polymerizing the polypeptide can be used for preparing subunit vaccines of African swine fever virus.
Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of 129 S. mitis bloodstream infection (BSI) isolates collected between 2001-2016 from clinically diagnosed IE cases in the UK to investigate genetic diversity, antimicrobial resistance, and pathogenicity. We show high genetic diversity of IE-associated S. mitis with virtually all isolates belonging to distinct lineages indicating no predominance of specific lineages. Additionally, we find a highly variable distribution of known pneumococcal virulence genes among the isolates, some of which are overrepresented in disease when compared to carriage strains. Our findings suggest that S. mitis in patients with clinically diagnosed IE is not primarily caused by specific hypervirulent or antimicrobial resistant lineages, highlighting the accidental pathogenic nature of S. mitis in patients with clinically diagnosed IE.
Patients receive selinexor PO and dexamethasone PO on days 1, 8 15, and 22, carfilzomib IV on days 1, 8, and 15, and pomalidomide PO on days 1-21. Treatment repeats every 28 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT and bone marrow biopsy and aspiration during screening and on the trial. Patients may optionally undergo blood sample collection during screening and on the trial.
BACKGROUND: Central line-associated bloodstream infections (CLABSIs) are among the most epidemiologically relevant health care-associated infections. The aseptic non-touch technique (ANTT) is a standardized practice used to prevent CLABSIs. In a pediatric hospital, the overall CLABSI rate was 1.92/1000 catheter days (CD). However, in one unit, the rate was 5.7/1000 CD.
METHODS: Nurses were trained in ANTT. For the implementation, plan-do-study-act (PDSA) cycles were completed. Adherence monitoring of the ANTT and epidemiological surveillance were performed.
RESULTS: ANTT adherence of 95% was achieved after 6 PDSA cycles. Hand hygiene and general cleaning reached 100% adherence. Port disinfection and material collection had the lowest adherence rates, with 76.2% and 84.7%, respectively. The CLABSI rate decreased from 5.7 to 1.26/1000 CD.
CONCLUSION: The implementation of ANTT helped reduce the CLABSI rate. Training and continuous monitoring are key to maintaining ANTT adherence.
A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicat-ing agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexi-ble double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The oper-ation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
This is a prospective exploratory study of nucleoside and monosaccharide supplement-ation and its effect on immunologic parameters in patients with evidence of altered glycosylation and immunologic abnormalities. Up to 50 subjects will receive escalating doses of oralmonosaccharide until a maximum tolerated dose is found and maintained for 6 weeks. Then nucleosidesupplementation will be added and the maximum tolerated dose will continue for 12 weeks. Parameters of interest will be assessed at NIH every 8 weeks. Themaximum participation time for each subject is 252 days. We will begin with PGM3 deficient patients, who will self-administer oral GlcNAc followed by dual supplementation with GlcNAc and Uridine. The remaining subjects will then receive these supplements following the same step-wise approach.
A clinician station supporting private and secure telemedicine session between an operator and a patient on a remote patient station terminal. The clinician stations comprising a base, an interactive device stand, and a display terminal. The interactive device stand includes an electronic device, a device casing, and an adjustable arm. The display terminal includes a display device, a display casing, and an adjustable arm. The electronic device and the electronic display device are electronically communicable over a network with a cloud based system that is configured to host a medical session between a patient in the patient station terminal and the operator using the clinician station. The clinician station further includes a floating camera that captures and transmits real-time images of the operator to the patient over the network.
Project PLUS is an HIV risk reduction/Highly Active Antiretroviral Therapy (HAART) adherence behavioral intervention for persons being released from prisons in Connecticut. The intervention is delivered one-on-one to HIV-infected individuals prior to release from incarceration (Group 1) vs. after release from incarceration (Group 2) vs. treatment as usual (Group 3). The primary hypothesis is that the intervention groups (Groups 1 \& 2) will demonstrate significantly greater reduction in rates of HIV sexual and drug risk behaviors and a significantly greater increase in HAART adherence compared to Group 3 participants at 4 months following release from prison. (However, those in Group 3 may come back to participate in the educational sessions, as non-study participants, after their participation has been completed). Based on the IMB model of health behavior change, the primary outcomes of interest are HIV risk reduction knowledge, motivation, behavioral skills (Fisher \& Fisher, 1992) and specific event-level partner-by-partner drug and sex risk outcomes including the frequency of unprotected sex episodes across different partners categorized by perceived HIV-status of each partner, numbers of different sexual partners, changes in the frequency of condom use, changes in reported adherence to HIV medication, and changes in reported drug use episodes across different partners categorized by perceived HIV-status of each partner. Additional outcomes of interest include greater knowledge regarding drug- and sex- related HIV risk behaviors and HAART adherence, greater motivation to reduce HIV risk behaviors and improve HAART adherence, enhanced skills for engaging in HIV risk reduction behaviors and HAART adherence. A comparison between Groups 1 \& 2 has never been examined, so an important part of this study is to explore this comparison.
PURPOSE:A cosmetic having improved touch, etc. of the base powder, comprising the powder coated with a poly (amino acid) or its derivative. CONSTITUTION:A cosmetic comprising the base powder, e.g. talc, zinc flower, or kaolin, coated with a poly (amino acid) or its derivative, e.g. poly (gamma-methyl L- glutamate), with the other materials. The poly (amino acid) or its derivative can solve safety problems, etc. due to the alkalinity, etc. of the powder to give a safe cosmetic having the particularly good covering and adhesive power and the smooth and desirable touch, because of essentially the same main chain as proteins.
Systems and methods for generating a quick start workout template and calibrating an electronic device using the workout template are provided. The electronic device may create and store a workout template to be used in conjunction with a workout. The workout template may be selected in a quick start fashion to restart the same workout. The workout template may be defined at least in part by a selection of any suitable workout goal and/or any suitable associated media. If the media associated with the workout goal is changed or is removed, a new workout template may be created. The electronic device may be calibrated or recalibrated using the workout template. If the electronic device is calibrated or re-calibrated with respect to a particular sensor, the electronic device may use the calibration in conjunction with any suitable workout template and the sensor to more accurately monitor the user's workout.