anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients will be randomized into two groups of spot placement. In the experimental arm, "Spot Delete" will be used to prohibit proton spots from being placed in the rectum, sigmoid, and small bowel. In the control arm, proton spots are placed by the treatment planning system are not modified. Medical staff will document gastrointestinal toxicities (diarrhea, fecal incontinence, proctitis, and rectal hemorrhage) and genitourinary toxicities (hematuria, urinary incontinence, urinary retention, urinary obstruction, urinary pain, urinary frequency, and urinary urgency) in the electronic medical record.

This study carries the same risks as regular proton therapy. Proton therapy, like other cancer treatments, may cause the aforementioned side effects. It is important to note that the "Spot Delete" technique aims to specifically address the bladder and bowel reactions, so there might be a potential reduction in this particular risk. Dose constraints will be the same for each treatment arm. Though not expected, it is theoretically possible that this method may counterintuitively increase side effects involving the bladder or bowel. Likewise, increased side effects in other organs are not expected, but are theoretically possible. For this reason we believe there is clinical equipoise between the two trial arms.
PROBLEM TO BE SOLVED: To obtain an active oxygen eliminating agent or a skin beautifying cosmetic composition from new and safe plants. SOLUTION: This active oxygen eliminating agent or skin beautifying cosmetic composition comprises one or more kinds of plant extracts selected from among extracts of plant parts of Haematoxylon campechianum L., Lindera strychnifolia (Sieb.et Zucc.)F. Vill., Arctostaphylos uva-ursi (L). Spreng., Lycium chinense Mill., Perilla frutescens Britton var. acuta Kudo, Rubus suavissimus S.Lee, Nelumbo nucifera Gaertner and Lavandula vera D.C. The agent has excellent active oxygen eliminating action and further can improve a roughened skin and impart gloss and tenseness to the skin. Furthermore, the agent can be also utilized for general foods and beverages.
Bronchoscopies are performed in strict accordance with consensus guidelines. The left or right lung is examined with a flexible fiberoptic bronchoscope. If localized infiltrates are present on the chest radiograph, the tip of the scope is wedged into a subsegment of the area displaying the most marked opacity. In the presence of diffuse opacity or when no clear roentgenographic abnormalities are observed, the tip is positioned in the lingula or right middle lobe. Five 20-ml aliquots of sterile normal saline are then injected and reaspirated with a syringe. Bronchoscopy is then repeated in the same manner in the contralateral lung with a second, sterile bronchoscope of the same brand and model.
After agreement with the written informed consent, 30 volunteers (10 healthy volunteers and 20 patients with severe OSA), male and female, aged \> 21 years were recruited in the Sleep Laboratory of Hospital das Clínicas da Faculdade de Medicina (FMUSP). The volunteers were evaluated at the Sleep Laboratory (Incor) in two phases. First Phase: volunteers were assessed for breathing route awake and asleep (including respiratory events in OSA patients) and were indicated as nasal breathing and oronasal breathing. Second phase for OSA patients: two manual full-night CPAP titration with nasal and oronasal masks in a randomized order, 14 days apart. Data and fluids were analyzed before and after both titration studies comparing both masks including supine and lateral position during asleep and CPAP titration. Third phase for OSA patiens: patients were treated with the best interface found in CPAP titration study during 30 days and patients were assessed for sleep quality, excessive sonolence during the day, airway symptoms, airway defense mechanisms biomarkers (mucociliary clearance, mucus properties, citology, inflammation cytokines and adhesion molecules and others) and serum cytokines and miRNA.
For patients randomized to the treatment arm, exogenous BLES will be administered as soon as possible and within 48 hours of intubation. BLES will be administered daily for up to 3 doses, or until the patient is liberated from the ventilator.
The present invention relates to a method for manufacturing a cosmetic composition for reducing skin wrinkles or enhancing skin elasticity using naturally-derived ingredients including Cynanchum wilfordii Hemsley and the cosmetic composition manufactured thereby. The method comprises the following steps: (A) mixing Cynanchum wilfordii Hemsley, one or more ingredients selected from the group consisting of Rubus coreanus fruits, Cuscuta chinensis Lamark seeds, Cnidium monnieri (L). Cussion fruits, Lycium chinense Miller fruits, Schisandra chinensis fruits, Dioscorea batatas Decaisne roots, and acanthopanax, brown rice, leaven, grain syrup, effective microorganisms, and concentrated mineral water and then adding deep sea water and loess jijangsu, before primarily fermenting the same; (B) injecting air under the same temperature condition as the primary fermentation and fermenting secondarily; (C) mixing Cynanchum wilfordii Hemsley, Astragalus membranaceus BUNGE, one or more ingredients selected from the group consisting of Cistanche deserticola Y. C. Ma, Morinda officinalis roots, Eucommia ulmoides OLIVER, Polygala tenuifolia Willdenow, Phyllostachyos caulis in Taeniam, Acorus graminens SOLAND, Rehmanneh glutinosa Libosch. var. purpurea Mak., Poria cocas Wolf., Polydonati rhizoma, Cinnamomum cassia Presl, red ginseng, Inonotus obliquus, pine nuts, and walnuts, one or more ingredients selected from the group consisting of licorice and Lycium chinense Miller fruits, concentrated mineral water, and deep sea water, and preparing an extract by hot water extraction; (D) separating the product fermented at the step (B) into a fermented liquid and a residue by filtration; (E) preparing an extract from the residue separated at the step (D) by hot water extraction; and (F) mixing the fermented liquid separated at the step (D), the extract extracted at the step (E), and the extract extracted at the step (C). Therefore, the cosmetic composition can enhance skin elasticity, excellently reduce skin wrinkles, and supplement a female hormone in a menopausal woman.
The present invention provides external application medicine for treating scalds and a use method of the external application medicine. The external application medicine comprises main medicine A and auxiliary medicine B. The main medicine A comprises water, phenol and golden thread. The auxiliary medicine B comprises water and potassium permanganate. When the external application medicine is used, the main medicine A is embrocated and then the auxiliary medicine B is embrocated after the main medicine A is dried. The external application medicine has the advantages of low cost, simple and easy preparation, easy use, sanitation, high cure rate, good therapeutic efficacy and low rate of leaving scars, and is applicable medicine for scalds.
Those randomized to the delayed arm of the study, will receive TAU and wait 14 weeks before receiving the intervention. TAU will include ongoing review by the patient's primary care physician, neurologist and PD nurse. TAU does not preclude clinically indicated adjustments to medication or specialist referrals but physicians are asked to keep medication constant if possible. For patients with PD ordinary treatment includes a multitude of interventions, including pharmacological treatment, speech therapy and physical therapy. Pharmacological interventions include the use of dopaminergic treatments, including levodopa and dopamine agonist use, with adjunct use of monoamine oxidase B-inhibitors.
Risk Summary 

Cyclosporine and its metabolites are present in human milk following oral and intravenous administration. Adverse effects on the breastfed infant have not been reported. There are no data on the effects of the drug on milk production. The alcohol content of cyclosporine capsules, (modified) should be taken into account when given to lactating women (see WARNINGS, Special Excipients). Lactating women are encouraged to avoid additional alcohol intake during treatment. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for cyclosporine capsules, (modified) and any potential adverse effects on the breastfed infant from cyclosporine capsules, (modified) or from the underlying maternal condition.
General information:(1)Record the gestational age, birth weight, length, delivery way, Apgar score, maternal pregnancy status, prenatal bleeding or not after admission.(2)PS use, ventilator mode, other illness and complications should be recorded during hospitalization. (3) Record the baby's heart rate, respiratory rate, blood pressure, body surface area on every check.
The practice of placing vascular catheters is used many times every day at almost every hospital. It is a safe procedure which generally does not imply problems. Though the procedural optimum aren't reached. The procedure still fails some times and induce complications. When the catheter is placed using the traditional method the pulse is palpated by the operator's fingers. This is only to be done near the hand wrist. In this position the catheter steadiness is fragile but because the pulse can't be sensed more proximal the operator is forced to choose this position. This it though a problem that can be solved by non invasive visualization technology. Ultrasound-guidance for central vascular access is already well-established. However, in recent years ultrasound-guidance for peripheral vascular access has gained popularity too. The evidence of multiple studies demonstrates increased success rate and reduced complication rate with ultrasound compared to blind landmark technique for vascular catheter placement.

In recent years there have been both procedural technique and technology improvements in the field of ultrasound. This has led to the improvement of procedural catheterisation techniques that now can be done by novices with higher attempt success rate than traditional method. One technique that is gaining success is the short-axis-out-of-plane technique (SAX-OOP) with dynamic-needle-tip-tracking (DNTT).Using the ultrasound machine the needle can be placed in a more proximal direction on the forearm and the investigators believe that by the help of the exposed procedure on the monitor many complications can be reduced.

Hypothesis; Firstly the investigators hypothesize that the pain induced by the conventional method inclusive preoperational lidocaine injection will be the same or more intense than using DNTT without local anesthesia. Secondly the investigators hypothesize that the use of DNTT for the placement of the arterial catheter will decrease the time spend, amount of complications (hematoma), the number of pricks, the number of utilized catheters compared to the traditional palpation method. Thirdly the investigators claim that the best anatomical place to put the catheter isn't always corresponding with the spot chosen by palpation, which increase the number of failures.
Ensure accuracy when prescribing, dispensing, and administering hydrocodone bitartrate and acetaminophen oral solution to avoid dosing errors due to confusion between mg and mL, and with other hydrocodone bitartrate and acetaminophen oral solutions of different concentrations, which could result in accidental overdose and death. Ensure the proper dose is communicated and dispensed. When writing prescriptions, include both the total dose in mg and the total dose in volume.

Always use a calibrated measuring device when administering hydrocodone bitartrate and acetaminophen oral solution to ensure the dose is measured and administered accurately. Health care providers should recommend a dropper that can measure and deliver the prescribed dose accurately, and instruct caregivers to use extreme caution in measuring the dosage.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see WARNINGS]. 

Initiate the dosing regimen for each patient individually; taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see WARNINGS]. 

Follow patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with hydrocodone bitartrate and acetaminophen oral solution and adjust the dosage accordingly [see WARNINGS].
Patients in this group will receive the active comparator semaglutide 2.4mg. This is a medication which is distributed by an intramuscular injection once weekly.
The present invention relates to an external plaster for curing the pneumonitis of infants, which is prepared from Chinese herbal medicine according to a proportion. A finished product is ointment. The plaster comprises the Chinese herbal medicine with the weight percentage: 19.05% of Kadsura Pepper Stem, 4.17% of ephedra, 4.17% of dahurian angelica, 1.39% of dried tangerine peel, 1.39% of gypsum, 0.27% of litsea cubeba oil and 65.56% of idesia oil. The plaster has the preparation method that the Kadsura Pepper Stem, the ephedra, the dahurian angelica and the gypsum are respectively milled, crushed and sieved, substances under a sieve are taken and put into the litsea cubeba oil and the idesia oil, and the mixture is uniformly stirred to obtain the ointment by a stirrer. When the ointment is used, a carrier is used for making external plasters. The external plaster has the advantages of obvious effect on the treatment of the pneumonitis of infants, no toxic or side effect and safe use.
Recent evidence has supported a pathogenic role for neuroinflammation in Parkinson's disease (PD). Inflammatory response has been associated with symptoms and subtypes of PD. However, it is unclear whether immune changes are involved in the initial pathogenesis of PD, leading to the non-motor symptoms (NMS) observed in its prodromal stage. The current study aimed to characterize the behavioral and cognitive changes in a toxin-induced model of prodromal PD-like syndrome. We also sought to investigate the role of neuroinflammation in prodromal PD-related NMS. Male mice were subjected to bilateral intranasal infusion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or saline (control group), followed by comprehensive behavioral, pathological and neurochemical analysis. Intranasal MPTP infusion was able to cause the loss of dopaminergic neurons in the substantia nigra (SN). In parallel, it induced impairment in olfactory discrimination and social memory consolidation, compulsive and anxiety-like behaviors, but did not influence motor performance. Iba-1 and GFAP expressions were increased in the SN, suggesting an activated state of microglia and astrocytes. Consistent with this, MPTP mice had increased levels of IL-10 and IL-17A, and decreased levels of BDNF and TrkA mRNA in the SN. The striatum showed increased IL-17A, BDNF, and NFG levels compared to control mice. In conclusion, neuroinflammation may play an important role in the early stage of experimental PD-like syndrome, leading to cognitive and behavioral changes. Our results also indicate that intranasal administration of MPTP may represent a valuable mouse model for prodromal PD.
A cosmetic cream for application to dark complexions comprises a matured aqueous emulsion prepared from a major proportion of a non-drying animal, vegetable or mineral oil or fat, or a mixture thereof, and minor proportions of an oil-soluble emulsifying agent and a mucilaginous substance obtained by alkaline digestion of a pectocellulose or mucocellulose.  Specified oils and fats are lard, lard oil, hydrogenated fish oil, almond oil, olive oil, palm nut oil, palm kernel oil, arachis oil, hazel nut oil, cottonseed oil, rape seed oil, and petroleum oil.  Emulsifiers are partial esters of polyhydric alcohols with fatty acids containing at least 10 carbon atoms in the molecule e.g. glycol mono-oleate or monostearate, glyceryl mono oleate, glyceryl di-oleate, glyceryl monostearate, glyceryl distearate, glyceryl mono- and di-palmitate, and fatty alcohol containing at least 10 carbon atoms in the molecule e.g. cetyl alcohol, stearyl alcohol, lanolin and lanolin alcohols. Alternatively, the animal or vegetable oil may be partially hydrolyzed with e.g. dilute hydrochloric acid, and the emulsion so formed used without further addition of emulsifier.  The mucilage is prepared by digesting the rind of citrus fruits e.g. orange, lemon or grape-fruit, or commercial pectin with aqueous alkali metal hydroxide or carbonate e.g. by boiling 2 to 5 hours.  Other vegetable tissues which may be used are e.g. apples, pears, grapes, sugar beet, carrots, turnips, flax and rhamie fibre.  The mixture of oil-emulsion and mucilage is allowed to age e.g. 2 to 3 weeks, is mixed with further oil-emulsion and again aged until the desired dark colour is produced.  Optional additions are (a) glycerin, (b) preservatives, (c) perfumes, (d) antioxidants, (e) pigments, (f) waxes and (g) medicines e.g. estrogenic hormones, vitamin D, cholesterol, sulphur, boric acid and zinc oxide.
Aegilops species are wheat relatives that harbor valuable disease resistance genes for wheat breeding. The wheat Yr8 near-isogenic line AvSYr8NIL has long been believed to carry only Yr8 for race-specific all-stage resistance to stripe rust, caused by Puccinia striiformis f. sp. tritici, derived from Aegilops comosa. However, AvSYr8NIL has been found to have high-temperature adult-plant (HTAP) resistance in our field and greenhouse tests. To confirm both HTAP and Yr8 resistance, seeds from AvSYr8NIL were treated with ethyl methanesulfonate to generate mutant lines. The mutant lines with only Yr8 (M641) and only HTAP resistance (M488) were crossed with the susceptible recurrent parent Avocet S (AvS). The F1 and F4 lines of AvS/M641 were phenotyped with Yr8-avirulent races in the seedling stage at the low-temperature (4 to 20°C) profile, while the F1, F2, F4, and F5 lines of AvS/M488 were phenotyped with Yr8-virulent races in the adult-plant stage at the high-temperature (10 to 30°C) profile. Both Yr8 and the HTAP resistance gene (YrM488) were recessive. The F4 populations of AvS/M641 and AvS/M488 were genotyped using polymorphic Kompetitive allele-specific PCR markers converted from single-nucleotide polymorphisms. Yr8 was mapped to a 0.66-cM fragment, and YrM488 was mapped to a 1.22-cM interval on chromosome 2D. The physical distance between the two resistance genes was estimated to be more than 500 Mb, indicating their distinct loci. The mutant lines with separated resistance genes would be useful in enhancing our understanding of different types of resistance and in further studying the interactions between wheat and the stripe rust pathogen.
PURPOSE: Patients with spinal metastases undergoing surgical treatment face challenges related to preoperative anemia, intraoperative blood loss, and frailty, emphasizing the significance of perioperative blood management. This retrospective analysis aimed to assess the correlation between hemoglobin-related parameters and outcomes, identifying key markers to aid in blood management.
METHODS: A retrospective review was performed to identify patients who underwent surgical treatment for spinal metastases. Hb-related parameters, including baseline Hb, postoperative nadir Hb, predischarge Hb, postoperative nadir Hb drift, and predischarge Hb drift (both in absolute values and percentages) were subjected to univariate and multivariate analyses. These analyses were conducted in conjunction with other established variables to identify independent markers predicting patient outcomes. The outcomes of interest were postoperative short-term (6-week) mortality, long-term (1-year) mortality, and postoperative 30-day morbidity.
RESULTS: A total of 289 patients were included. Our study demonstrated that predischarge Hb (OR 0.62, 95% CI 0.44-0.88, P = 0.007) was an independent prognostic factor of short-term mortality, while baseline Hb (OR 0.76, 95% CI 0.66-0.88, P < 0.001) was identified as an independent prognostic factor of long-term mortality. Additionally, nadir Hb drift (OR 0.82, 95% CI 0.70-0.97, P = 0.023) was found to be an independent prognostic factor for postoperative 30-day morbidity.
CONCLUSIONS: This study demonstrated that predischarge Hb, baseline Hb, and nadir Hb drift are prognostic factors for outcomes. These findings provide a foundation for precise blood management strategies. It is crucial to consider Hb-related parameters appropriately, and prospective intervention studies addressing these markers should be conducted in the future.
The invention discloses liquid medicine for treating dermatoses, which is prepared by mixing the following ingredients by volume percentage: 82%-92% of glacial acetic acid and 8%-18% of diluent. The dilute is prepared by mixing clear water of fish pond silt and traditional Chinese medicine juice decocted by scandent hop and lygodium japonica, and the volume ratio of the clear water to the traditional Chinese medicine juice is 2:0.8-1.2. The clear water is obtained by extracting the silt from a fish pond, putting the silt into a nonmetallic container for standing for 24-48 hours, taking out supernatant water and filtering. The traditional Chinese medicine juice is obtained by adding one part by weight of dried scandent hop and one part by weight of dried lygodium japonica to 20-30 parts by weight of water, boiling, decocting, concentrating and filtering to obtain 3-5 parts by weight of traditional Chinese medicine juice. The liquid medicine has a better curative effect in treating the dermatoses such as beriberi, tinea pedis, skin tinea and eczema; in general, the dermatoses can be healed by using the liquid medicine for once; and the severe dermatoses can be healed by using the liquid medicine for at most three times. The liquid medicine has a better itching relieving effect after being applied on skin bitten by mosquitoes.
Participants will receive single oral dose of TAK-279 50 mg, on Day 1 of Period 1. Following Period 1 participants will receive single oral dose of TAK-279 50 mg on Day 11 and efavirenz 600 mg orally once daily (QD) on Day 1 through Day 15 of Period 2 in Part 3 of the study.
The invention discloses a proved recipe used for treatment of cold caused by wind-cold. Cold (including influenza) is acute upper respiratory inflammation caused by virus. Morbidity is highest when climate changes. In the field of traditional Chinese medicine, cold is divided into two kinds, wind-cold and wind-heat, according to the temperature of the environment and the difference of symptoms. Symptoms of cold caused by wind-cold include: intolerance of cold, fever, but intolerance of cold is higher, nasal obstruction, watery rhinorrhea, and headache, and may also include cough, no sweat, no thirsty and aches over the whole body. Chinese herbal medicine ingredients are taken as raw materials. The medicine is prepared by conventional boiling method, and the extracted liquid medicine is for oral administration. The proved recipe is prepared according to nosogenesis, suits the remedy to the case, possesses no toxic or side effects, and possesses remarkable therapeutic effects on symptoms of fever, chill, headache, no sweat, and aches over the whole body. The proved recipe used for treating cold caused by wind-cold is based on repeated researches for a plurality of years, and the summarize of cure of hundreds of patients; effective rate reaches 98% and cure rate reaches 92% according to clinical observation on curative effect. Effect of the proved recipe on cold is excellent, and the proved recipe also possesses significant curative effect on prevention of influenza. The proved recipe is capable of enhancing antiviral immunity function of human body. Treatment course is short; effects are achieved quickly; and the proved recipe is capable of preventing relapse, is convenient for taking, and is the only unique recipe used for treating cold caused by wind-cold.