anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A system is provided for processing blood from a blood source. The system cooperates with a disposable fluid flow circuit including a tubing line that is associated with a clamp of the system. The system also includes a sensor and a controller, which cooperate to determine whether the fluid flow circuit and/or the system itself is defective and/or if the fluid flow circuit has been installed onto the system improperly. If such an error or defect exists, then the controller determines whether a selected system state exists. The controller causes a change in the appearance of the display of the system, which includes displaying an interactive icon if the selected system state exists. The icon, when manipulated, causes the clamp to move from the closed condition to an open condition.
The preparation of new formula (I) diphenylmethylpiperazine derivatives is described, where A is a carbonyl or alkylaminocarbonyl group and B is a substituted or non-substituted heteroaryl group, cycloalkyl or cycloalkenyl, as well as its pharmaceutically stable addition salts. The new derivatives are synthesised through a reaction between diphenylmethylpiperazine, or an alkylamino derivative thereof, with a chloride of a heteroaromatic acid, in which the heteroatom should be nitrogen and which is substituted by a halogen, preferably chlorine or bromine or with the chloride of a bicyclo alkanoic or alkenoic acid. These compounds have pharmacological activity, notably antihistamine and antiallergic activity.< IMAGE >New derivs. of diphenylmethyl piperazine of formula (I), in which A is carboxyl or alkyl-amino carbonyl, and B is opt substd. hetero-aryl, or cycloalkyl or cycloalkenyl, and their acceptable addn. salts. They are made by reacting diphenyl methyl piperazine, or an alkylene-amino deriv., with a hetero-aromatic acid chloride, pref. with N as hetero-atom, which is substd. with halogen pref. chlorine or bromine, or reacting it with a bicyclo-alkanoic at alkenoic acid chloride.
<P>PROBLEM TO BE SOLVED: To provide a means for improving stability of a liquid crystalline system in a cosmetic composition in a liquid crystalline state.  <P>SOLUTION: The cosmetic composition comprises (1) a nonionic surfactant containing an oleic acid residue and/or an oleyl alcohol residue having 4-7 HLB and (2) an arginine soap of a 10-25C straight-chain or branched-chain structure-containing saturated fatty acid to form a liquid crystalline state. One or more kinds selected from an oleic acid ester having POE (1-5) and an oleyl ether having POE (1-5) are preferable as the nonionic surfactant containing an oleic acid residue and/or an oleyl alcohol residue having 4-7 HLB. Arginine laurate and/or arginine isostearate is preferable as the arginine soap of a 10-25C straight-chain or branched-chain structure-containing saturated fatty acid. Preferably, the cosmetic composition contains 1,2-pentanediol, etc.  <P>COPYRIGHT: (C)2007,JPO&INPIT
<P>PROBLEM TO BE SOLVED: To provide a medium management system, etc. capable of easily managing the receipt of a medium at a destination in the transfer of medical image data by using the medium.  <P>SOLUTION: A server 3 generates medium registration information based on patient information LID (Link Identification) and examination information LID included in the medical image data stored in the medium 9 when the server 3 creates the medium 9, and transmits the medium registration information to a PDI (Portable Data for Imaging) management device 11. The PDI management device 11 stores the medium registration information transmitted from the server 3 in a medium management table. When the medium 9 is received in another healthcare facility, the time of reception in the medium management table is updated based on the medium reception information transmitted from a server 3 in the hospital, and the reception of the medium 9 is registered.  <P>COPYRIGHT: (C)2010,JPO&INPIT
The control group will receive a 2h lecture on AOM, which is the "standard" teaching method. Given by a pediatrician or a senior pediatric resident, this lecture, using a PowerPoint© presentation support, encompasses clinical cases, notions of anatomy, epidemiology, pathophysiology, diagnostic criteria, treatment options, and prognosis, describes different ear examination techniques, and shows examples of different pathologies.
The novel compounds correspond to the formula I, in which the substituents have the meaning given in Patent Claim 1. These compounds are prepared by reaction of a compound of the formula II with a compound of the formula III, Y and Z in each case being different and either denoting hydrogen or the group -CH2-CH(OR1)-CH2-V and V being chlorine, bromine or iodine, or, if R1 is hydrogen, can also form the ethylene oxide ring together with this hydroxyl group. If appropriate, one or two nitro groups in a compound of the formula I obtained can be reduced to amino groups and/or the compounds obtained can be acylated with an acid or an acid derivative corresponding to the radical R1. The compounds obtained can be converted into their acid addition salts. The novel compounds are pharmacodynamically active and are suitable as an active component in medicaments. <IMAGE>
The invention comprises salts of sulphosuccinic half esters, having the formula <FORM:1077470/C2/1> in which R represents a C8- 20 alkyl group, A is either -CO-NR1- (where R1 is hydrogen, a hydroxyalkyl or an alkyl group) or the group -CH2-O-; m is an integer of 1-3, n is an integer of 0-10; either X or X1 is hydrogen and the other is SO3M and M represents one equivalent of a Group II or III metal, e.g. zinc, magnesium and aluminium.  The compounds are prepared by reacting maleic anhydride with a compound of formula R-A-[(CH2)mO]nH to form a maleic acid half ester which is sulphonated by a Group II or III metal sulphite. Specified compounds are the zinc salt of the sulphosuccinic acid half-ester of undecylenic acid monoethanolamide, and the magnesium, zinc and aluminium salts of the sulphosuccinic half-ester of lauryl alcohol diglycol ether.  The compounds are useful in cosmetic preparations (see Division A5).ALSO:Topical and other cosmetic or pharmaceutical preparations, including hair and bath preparations, skin creams, liquid cleansing and washing agents, have incorporated therein a salt of formula:-  <FORM:1077470/A5-A6/1> wherein R is an alkyl group (C8-20), A is either -CO-NR1 (where R1 is a hydrogen atom, a hydroxyalkyl or an alkyl group) or the group -Cn2-O-; m is from 1-3, and n is from 0-10; either X or X1 is a hydrogen atom and the other is the group -SO3M and M represents one equivalent of a Group II or III metal.  The preparations may be aqueous-or alcohol-based.
PURPOSE:To provide a capsule suitable for the sampling of the specimen in the digestive tracts of an animal or administering a drug to an animal by feeding, by placing a spring made of a shape memory alloy which is restored to its original shape by external magnetic field in one of the chambers of a capsule partitioned with a slidable piston. CONSTITUTION:The case 1 made of a plastic, etc. is partitioned with a slidable piston 3 into the front case 11 and the rear case 12. A valve 2 is attached to the front end of the front case 11, and a spring 6 made of a shape memory alloy is placed in the rear case 12 under defomred state. In case of the administration of a drug, the drug 5 is put into the front case 11, and the spring 6 is contracted from the original extended state. For the sampling of a specimen, the spring 6 is placed in the rear case 12 in an extended state. The spring 6 is constructed of a core material 6a made of a shape memory alloy coated with a coating layer 6b having high eddy current loss (e.g. iron, ferrite, etc.). When the srping is exposed to an alternating magnetic field, the core material 6a is heated by the Joule heat caused by the eddy current, and the spring is restored to the original state.
The invention provides a pig gall and earthworm asthma-relieving tablet, and belongs to traditional Chinese and western medicine compound preparations. The tablet has the effects of effectively relieving cough and asthma and eliminating phlegm by means of the pharmacologic action of medicinal materials, and health of patients can be recovered. The tablet is prepared from the following components in the traditional Chinese medical formula: 18-38g of pig gall powder, 70-110g of earthworm, 38-58g of radix stemonae, 9-28g of fructus mume, 19-38g of alum, 9-38g of semen brassicae and 19-38g of ginger, and the components in the western medical formula comprise 8-19g of aminophylline and 0.5-2.8g of promethazine hydrochloride. The traditional Chinese and western medicinal materials are matched with syrup and honey and respectively prepared according to different properties of the medicinal materials, and are processed into sugar coated tablets or film-coated tablets. The tablet is taken orally, and the dosage is taken according to advice of doctors. The tablet is prepared from pig gall powder and earthworm as main drugs, is capable of clearing lung, removing toxicity, eliminating phlegm, relieving cough, regulating qi and relieving asthma, can be used for treating various respiratory system diseases, such as cough, asthma, senile chronic bronchitis, asthmatic bronchitis, emphysema and the like, in clinical application.
Patients receive one or two treatment courses of MabionCD20, each consisting of two 1000 mg i.v. infusions at an interval of 14 days. Investigational drug will be administered at Day 1 and Day 15, and, if patient is eligible for re-treatment, also at Week 24 and Week 26.
The skin disorder acne, as well as one or more isolated pimples, are treated by applying to the skin, over the skin disorder, a flexible moisture-containing hydrophilic hydrogel patch that includes a backing support such as paper, cloth or plastic and a water-based hydrogel layer applied to the backing. The hydrogel layer comprises a hydrophilic natural or synthetic polymer dispersed in water to provide body and can be a tacky adhesive. The polymer can comprise any high molecular weight hydrophilic carbohydrate such as karaya, cornstarch, or kelp and/or a synthetic hydrophilic polymer such a polyacrylamide or polyacrilic acid. A humectant such as an alcohol containing two or more hydroxyl groups, i.e., a polyhydric alcohol, keeps the adhesive layer moist. A solute such as salt, protein, sugar or an alcohol is dissolved in the water in a quantity sufficient to raise the osmotic pressure enough to maintain the adhesive hydrogel layer in a hypertonic state with respect to the underlying skin tissue. The hydrogel adhesive which hydrates the upper layer of skin forms a hydrophilic bridge with the patient's skin that allows fluid to be drawn by osmotic pressure from the skin disorder through the normally dry stratum corneum into the patch. Another aspect of the invention is a hypertonic moisture-containing adhesive patch itself.
The invention discloses lignans compounds and a preparation method and application thereof. According to the structural formulas of the compounds, R1 is -OH, R2 is -OCH3, a molecular formula is C20H24O8, and one compound is named as marphenol E; and -OCH2O- is between R1 and R2, a molecular formula is C20H22O8, and the other compound is named as marphenol F. According to the preparation method, the lignans compounds are prepared from the raw materials including dried branches, leaves and/or fruits of schisandra chinensis. The preparation method comprises the steps of extract extraction, organic solvent extraction, silica column chromatography and high pressure liquid chromatography separation of the raw materials. The invention further discloses the application of the lignans compounds to preparation of anti-AIDS medicines. According to cytotoxicity detection on C8166 host cells and inhibition tests on an HIV-1IIIB-induced cytopathic effect (CPE) of the C8166, the two fluorenone compounds, namely the marphenol E and the marphenol F, have good anti-HIV-1 activity, the EC50 values of the two fluorenone compounds are respectively 3.47 microgram/mL and 2.97 microgram/mL, and the therapeutic index (IT) values of the two fluorenone compounds are respectively 21.18 and 27.64. The fluorenone compounds have novel structures and high activity, and can serve as guiding compounds of the anti-AIDS medicines.
BACKGROUND: Recent research reported that frailty was prevalent among adults with chronic kidney disease (CKD) in clinical trials, and monocytes illustrated a similar difference in these two diseases compared to the normal. However, the scientific evidence for a causal relationship between these two diseases was lacking, with further exploration into whether monocytes co-regulate them.
METHODS: We aimed to integrate large-scale Mendelian randomization (MR) and single-cell transcriptome analysis to determine whether there was a causal relationship between frailty and CKD (Bidirectional two-sample Mendelian determined the causal direction), whether monocytes impacted them, and whether the two diseases shared genetic variation sites. Based on 441 Genome-wide association study datasets, this study utilized five MR methods, multiple sensitivity analysis, and corresponding single-cell transcriptome datasets as proof.
RESULTS: The association between frailty and CKD was significantly causal, and frailty increased the risk of CKD in patients (OR (95 %CI): 3.5597 (1.8369-6.8982), p = 0.000168909). The exposure monocyte can increase the risk of frailty and CKD in patients, especially with high expression of HLA genes in these cells. The existing two-sample MR results cannot reject the hypothesis that monocytes increase the risk of CKD by inducing frailty. rs9275271' 1mb genetic location above and below had been proven to be an effective genetic space for both frailty and CKD.
CONCLUSION: We conducted the largest MR to date on frailty, monocyte, and CKD, and found a significant causal association between frailty and CKD, with the single-cell analysis confirmed. The exposure monocytes increased the risk of frailty and CKD, particularly with high expression of HLA genes in these cells. We identified a potential common genetic variant space, rs9275271, associated with frailty and CKD, providing insights into the genetic basis of these conditions.
After mothers are informed about the study, mothers who agree to participate in the study will be included in the control group by randomization method. No intervention will be made to mothers in the control group. The mothers' state anxiety levels and milk quantities will be evaluated at the first meeting with the mothers and every day for four days. Mothers' anxiety levels will be evaluated with the "State Anxiety Inventory". Mothers' anxiety levels and milk quantities will be evaluated every day at 11.45 when they come to the NICU to express milk.
Forty-three adult patients scheduled for elective two valve replacement/repair were enrolled into randomised single-centre study. All interventions were performed in cardiosurgical department of City hospital #1 (Arkhangelsk, Russian Federation) by the same surgical team. Three patients were excluded from the analysis; two - due to protocol violation and one - due to inadequate surgical correction diagnosed by intraoperative transoesophageal echocardiography.

Day before surgery patients were asked for informed consent and randomized in two groups. In the first group postoperative haemodynamic optimization was targeted on parameters provided by pulmonary artery catheter (the PAC-group, n = 20): pulmonary arterial occlusion pressure, cardiac index (LifeScope monitor, Nihon Kohden, Japan) and hemoglobin blood level. In the second group haemodynamics was managed using parameters given by transpulmonary thermodilution (the COMPLEX-group), that included cardiac index, global end-diastolic volume index, extravascular lung water index, continuous central venous oxygen saturation, and oxygen delivery index as measured with PiCCO2 monitor (Pulsion Medical Systems, Munich, Germany. In addition, mean arterial pressure, heart rate, and hemoglobin concentration were included into both PAC- and PiCCO2-driven protocols.
Adhese®Universal (ADU)apply by self-etch (SE) mode. Starting with the enamel, thoroughly coat the tooth surfaces (enamel and dentin) to be treated with ADU; Adhesive will be scrubbed into the tooth surface for at least 20 seconds. Adhesive will be dispersed with compressed air until a glossy, immobile film layer results.Light-curing for 20 s with a light emitting diode unit (LED light), with an intensity of 1000mW/cm2.
Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR+/+) mice exhibited increased fat mass and trended to obesity phenotype. Non-target metabolomics showed that TIGAR caused the dysregulation of the metabolism profile. The quantitative transcriptome sequencing identified an increased levels of LRRK2 and RAB7B in the adipose tissue of TIGAR+/+ mice. It was confirmed in vitro that TIGAR overexpression increased the levels of LRRK2 by inhibiting polyubiquitination degradation, thereby suppressing macroautophagy and chaperone-mediated autophagy (CMA) while increasing lipid accumulation which were reversed by the LRRK2 inhibitor DNL201. Furthermore, TIGAR drove LRRK2 to interact with RAB7B for suppressing lysosomal degradation of lipid droplets, while the increased lipid droplets in adipocytes were blocked by the RAB7B inhibitor ML282. Additionally, fat-specific TIGAR knockdown of TIGAR+/+ mice alleviated the symptoms of obesity, and adipose tissues-targeting superiority DNL201 nano-emulsion counteracted the obesity phenotype in TIGAR+/+ mice. In summary, the current results indicated that TIGAR performed a vital function in the lipid metabolism through LRRK2-mediated negative regulation of macroautophagy and CMA in adipocyte. The findings suggest that TIGAR has the potential to serve as a viable therapeutic target for treating obesity and its associated metabolic dysfunction.
Loss of cell polarity and disruption of tissue organization are key features of tumorigenesis that are intrinsically linked to spindle orientation. Epithelial tumors are often characterized by spindle orientation defects, but how these defects impact tumor formation driven by common oncogenic mutations is not fully understood. Here, we examine the role of spindle orientation in adult epidermis by deleting a key spindle regulator, LGN, in normal tissue and in a PTEN-deficient mouse model. We report that LGN deficiency in PTEN mutant epidermis leads to a threefold increase in the likelihood of developing tumors on the snout, and an over 10-fold increase in tumor burden. In this tissue, loss of LGN alone increases perpendicular and oblique divisions of epidermal basal cells, at the expense of a planar orientation of division. PTEN loss alone does not significantly affect spindle orientation in these cells, but the combined loss of PTEN and LGN fully randomizes basal spindle orientation. A subset of LGN- and PTEN-deficient animals have increased amounts of proliferative spinous cells, which may be associated with tumorigenesis. These results indicate that loss of LGN impacts spindle orientation and accelerates epidermal tumorigenesis in a PTEN-deficient mouse model.
BACKGROUND: Chronic kidney disease (CKD) poses significant health risks due to its asymptomatic nature in early stages and its association with increased cardiovascular and kidney events. Early detection and management are critical for improving outcomes.
OBJECTIVE: This study aimed to develop and validate a prediction model for hospitalization for ischemic heart disease (IHD) or cerebrovascular disease (CVD) and major kidney events in Japanese individuals with mild CKD using readily available health check and prescription data.
METHODS: A retrospective cohort study was conducted using data from approximately 850,000 individuals in the PREVENT Inc. database, collected between April 2013 and April 2023. Cox proportional hazard regression models were utilized to derive and validate risk scores for hospitalization for IHD/CVD and major kidney events, incorporating traditional risk factors and CKD-specific variables. Model performance was assessed using the concordance index (c-index) and 5-fold cross-validation.
RESULTS: A total of 40,351 individuals were included. Key predictors included age, sex, diabetes, hypertension, and lipid levels for hospitalization for IHD/CVD and major kidney events. Age significantly increased the risk score for both hospitalization for IHD/CVD and major kidney events. The baseline 5-year survival rates are 0.99 for hospitalization for IHD/CVD and major kidney events are 0.99. The developed risk models demonstrated predictive ability, with mean c-indexes of 0.75 for hospitalization for IHD/CVD and 0.69 for major kidney events.
CONCLUSIONS: This prediction model offers a practical tool for early identification of Japanese individuals with mild CKD at risk for hospitalization for IHD/CVD and major kidney events, facilitating timely interventions to improve patient outcomes and reduce healthcare costs. The models stratified patients into risk categories, enabling identification of those at higher risk for adverse events. Further clinical validation is required.
Hip fracture in the elderly is associated with excess mortality of 5 to 20%, and mobility problems that usually results in costly hospital stays and lengthy rehabilitation procedures. With this increase in the aging population, hip fracture represents a major and a fast growing health care problem in Taiwan. Currently, the incidence rate of hip fractures is 10 times of the incidence rate for the general population. Despite the use of advanced treatment, the one-year mortality rate (15.4%) remains significant, and many of the patients never recover completely in terms of activities of daily living functions. Many studies in the United States have proved that elderly patients with hip fracture can benefit from post-operative rehabilitation, early discharge planning programs, or transitional care programs. However, little is known about what intervention should be attempted for these patients and their families in Taiwan.

The purpose of this study is to compare the costs and effectiveness of three care models- acute/sub-acute, comprehensive, and routine care models for hip fractured elders in Taiwan.
An animal is immunized with the A chain and the B chain of a receptor and then mRNA is extracted from spleen cells of this animal. Next, the L-chain and H-chain variable regions are collected by RT-PCR with the use of primers corresponding to the variable regions including CDR. Single-strand Fv is synthesized by assembly PCR and thus a phage library is constructed. Next, antigen-binding antibody clones are concentrated and cloned by panning. The single-strand variable region is inserted between a signal sequence for animal cells and CH1-hinge-CH2-CH3 to prepare an scFv-CH1-Fc expression vector. By transferring various combinations of the vector into cells, antibodies are expressed and an antibody clone showing a ligand-like activity is selected.