anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To improve the appearance caused by thin hair by using a hair tonic by formulating a coloring agent for coloring the scalp with the content of the hair tonic to urge the continuous use of the hair tonic for exhibiting the hair growth effects. SOLUTION: An adequate amount of the coloring agent and a fixing agent for coloring the scalp is formulated with the content of the recipe for the hair tonic. For example, red no.227, blue no.1, yellow no.203, and the like, in adequate amounts as coloring matters are mixed to provide an approximate color of the hair, and the obtained coloring matter and an ammonium salt of an alkyl acrylate copolymer, or the like, of a film-forming agent for urging the fixing to the scalp are mixed and formulated with the content of the hair tonic. When using the obtained hair tonic, an adequate amount of the content 1 obtained by the above recipe is coated by holding a container 2. The scalp is colored and the thinness of the hair becomes inconspicuous by coating the hair tonic on the scalp part where the hair is thinned so as to be useful for improvement of the appearance. Accordingly, the requirement of the improvement of the appearance is related to the continuous application, and is useful for exhibition of the effects caused by the continuous application of the hair tonic.
OBJECTIVE: Difficult-to-heal wound is a prevalent and significant complication of diabetes, characterized by impaired functionality of epithelial cells such as fibroblasts. This study aims to investigate the potential mechanism of ADSC-Exos promoting diabetic wound healing by regulating fibroblast function.
MATERIALS AND METHODS: ADSC-Exos were confirmed through TEM, NTA, and Western Blot techniques. The study conducted on rat skin fibroblasts (RSFs) exposed to 33 mmol/L glucose in vitro. We used cck-8, EDU, transwell, and scratch assays to verify the proliferation and migration of RSFs. Furthermore, levels of TGF-β1 and α-SMA proteins were determined by immunofluorescence and Western Blot. RSFs were transfected with miR-128-1-5p mimics and inhibitors, followed by quantification of TGF-β1, α-SMA, Col I and Smad2/3 protein levels using Western Blot. In vivo, the effects of ADSC-Exos on diabetic wounds were assessed using digital imaging, histological staining, as well as Western Blot analysis.
RESULTS: In vitro, ADSC-Exos significantly enhanced proliferation and migration of RSFs while reducing the expression of TGF-β1 and α-SMA. In vivo, ADSC-Exos effectively promoted diabetic wound healing and mitigated scar fibrosis. Additionally, ADSC-Exos exhibited elevated levels of miR-128-1-5p, which targets TGF-β1, resulting in a notable reduction in TGF-β1, α-SMA, Col I and smad2/3 phosphorylation in RSFs.
CONCLUSION: In conclusion, our results demonstrated that ADSC-Exos promoted diabetic wound healing, and inhibited skin fibrosis by regulating miR-128-1-5p/TGF-β1/Smad signaling pathway, which provides a promising innovative treatment for diabetic wound healing.
BACKGROUND: Changes in the skin structure, including the collagen and elastin content, have been reported with massive weight loss (MWL) following bariatric metabolic surgery (BMS) and have been correlated to a higher risk of complications after body-contouring surgery (BCS). This study aimed at comparing the histological characteristics of the skin of patients having surgical MWL (SMWL) post-BMS to those with non-surgical massive weight loss (NSMWL).
METHODS: This prospective study compared the epidermal thickness, and collagen and elastin fibers content in 80 skin biopsies obtained from BCS procedures performed to patients who experienced MWL defined more than 50% of excess weight loss (%EWL) either SMWL (40 biopsies) or NSMWL (40 biopsies). Twenty biopsies in each group were obtained from abdominoplasties and 20 from breast reductions. Epidermal thickness was measured in H&E-stained sections, collagen fibers were assessed using Masson trichrome-stained sections, and elastin fibers were assessed using Modified Verhoeff's stained sections. Image analysis software was used to calculate the fractions of collagen and elastin fibers.
RESULTS: This study included 77 patients, 38 SMWL patients, and 39 NSMWL patients. The SMWL group had a significantly higher age (p < 0.001), a longer time interval from intervention (p < 0.001), higher initial weight (p < 0.001), higher initial BMI (p < 0.001), lower current weight (p = 0.005), lower current BMI (p < 0.001), and significantly higher %EWL than NSMWL group (p < 0.001). No significant differences were detected between the two groups regarding complications after abdominoplasty (p = 1.000). The elastic fibers content in the dermis was significantly higher in the abdominal region of the NSMWL group than SMWL (p = 0.029). All other parameters showed non-significant differences between NSMWL and SMWL in the skin of abdomen and breast.
CONCLUSION: The SMWL group had a significant reduction in elastic fiber content in the skin of the abdomen compared to the NSMWL group. The collagen content was equally reduced in both groups with non-significant differences in both breast and abdomen regions in both groups.
A system for component-based aggregation of medication orders may include a processor and a memory. The processor may receive a display that lists a queue of medication orders to be prepared by a healthcare worker, the medication orders indicating component medications that will be used to prepare ordered medications. The processor may receive a selection of a first medication order listed in the queue, wherein the first medication order indicates a first component medication. The processor may determine a second medication order listed in the queue that indicates the first component medication. The processor may rearrange the displayed queue such that the second medication order is listed adjacent to the first medication order. The processor may notify the healthcare worker of the second medication order by displaying an indication of the second medication order separately from the queue.
The present invention relates to chloromycetin kibe ointment which is prepared from the components of 3 to 8 wt% of chloromycetin, 0.08 to 0.4 wt% of prednisone acetate, 0.04 to 0.2 wt% of chlorpheniramine maleate and medical vaseline as the rest, wherein chloromycetin principally realizes the action of relieving inflammation and resisting bacteria; prednisone acetate has the action of resisting inflammation and infection; chlorpheniramine maleate has the action of resisting anaphylaxis and relieving itching. The chloromycetin kibe ointment has the strong action of resisting bacteria and anaphylaxis, and relieving inflammation and itching, and is applied to afflicted parts so that the ointment can effectively improve the blood circulation of diseased regions, promotes the growth of epithelial tissue, quickly eliminates a series of symptoms of redness, turgescence, heat, itching, pains, etc. and has the action of eliminating old kibe scars. Thereby, the goal of rapidly, effectively and completely curing kibe is realized. The cure rate reaches 100%. I degree and II degree frozen patients can be cured after two to three days, and III degree patients only needs four to five days.
This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
PURPOSE: A mordant hair dyeing composition containing dye, mordant, swelling agent, reducing agent, antioxidant and selectively polymer film forming agent, solvent or pH-adjusting agent is provided to ensure excellent color expression and dyeing persistence. CONSTITUTION: A hair dyeing composition contains dye, mordant, swelling agent, reducing agent, and antioxidant. The composition further contains polymer film forming agent and solvent or pH adjusting agent. The reducing agent is thiol or salt thereof, phosphine or salt thereof, bisulfite or salt thereof, sulfite or salt thereof, or ester thereof. The antioxidant is erythorbic acid, ascorbic acid, or salt thereof. The composition further contains tackifier, surfactant, polyols, hair conditioning agent, or perfume. The composition is used in the form of liquid, cream, lotion, gel, or aerosol.
Two different settings will be used. In the first experiment, healthy subjects will make 15, 30, and 45-degree head tilt to the left and right side while they are standing. In every position, 3 measurements will be done. In the second experiment, 40 health subjects will make the same head maneuvers on the 20 cm thick soft surface. We will compare the effects of both head tilt and soft surface. All measurements will be done with a virtual SVV system(Interacoustics).
PURPOSE:To obtain a white hair blackening agent, containing idebenone and capable of blackening white hair. CONSTITUTION:The objective substance, containing idebenone as an active ingredient and obtained by mixing the idebenone with a normally used carrier, excipient, binder, diluent, etc., and preparing a pharmaceutical by a conventional method. The idebenone is blended in an amount of 0.1-15wt.%. The agent can be prepared in the form for oral administration of granule, powder, tablet, capsule or syrup or percutaneous administration of cosmetics, such as liquid, lotion, cream or ointment. The dose thereof for an adult per day is within the range of 10-150mg idebenone and about 1/10 based on the above-mentioned dose for percutaneous administration. The chemical name of the idebenone is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone.
Paclitaxel (PTX) is a chemotherapeutic agent that is widely used for the treatment of several types of tumors. However, PTX-induced peripheral neuropathy (PIPN) is an adverse effect generally induced by long-term PTX use that significantly impairs the quality of life. Necroptosis has been implicated in various neurodegenerative disorders. Necroptosis of dorsal root ganglion neurons triggers the pathogenesis of PIPN. Therefore, the present study aims to investigate the role of spinal neuronal necroptosis in PIPN. It also explores the potential role of microglial polarization in necroptosis. We established rat models of PIPN via quartic PTX administration on alternate days (accumulated dose: 8 mg/kg). PTX induced obvious neuronal necroptosis and upregulated the expression of receptor-interacting protein kinase (RIP3) and mixed lineage kinase domain-like protein (MLKL) in the spinal dorsal horn. These effects were inhibited with a necroptosis pathway inhibitor, necrostatin-1 (Nec-1). The effect of microglial polarization on the regulation of spinal necroptosis was elucidated by administering minocycline to inhibit PTX-induced M1 polarization of spinal microglia caused by PTX. We observed a significant inhibitory effect of minocycline on PTX-induced necroptosis in spinal cord cells, based on the downregulation of RIP3 and MLKL expression, and suppression of tumor necrosis factor-α and IL-β synthesis. Additionally, minocycline improved hyperalgesia symptoms in PIPN rats. Overall, this study suggests that PTX-induced polarization of spinal microglia leads to RIP3/MLKL-regulated necroptosis, resulting in PIPN. These findings suggest a potential target for the prevention and treatment of neuropathic pain.
Computer-implemented systems and methods connect users interested in one or more cosmetic procedures with a plurality of practitioners. Using an application of the system, each user submits a request, which includes one or more photographs of himself/herself and a summary of the user's desired goals. The request is transmitted to the practitioners. The practitioners receive the request, optionally use a morphing application provided by the application to manipulate the photograph(s) to mimic the user's desired results, and send a response to the user. Once the user receives the responses, the user can choose to continue corresponding with one or more practitioners to fine-tune or learn more about the projected results, which again may proceed by the exchange of morphed photographs. Once the user is satisfied with one or more of the projected results, the user can send an appointment request to schedule an in-person appointment with one or more practitioners.
A mechanism is provided in a data processing system for refining lesion contours with combined active contour and inpainting. The mechanism receives an initial segmented medical image having organ tissue including a set of object contours and a contour to be refined. The mechanism inpaints object voxels inside all contours of the set. The mechanism calculates an updated contour around the contour to be refined based on the in-painted object voxels to form an updated segmented medical image. The mechanism determines whether the updated segmented medical image is improved compared to the initial segmented medical image. The mechanism keeps the updated segmented medical image responsive to the updated segmented medical image being improved.
AIM: To describe the timing and characteristics of midwives' hands-on interruptions of newborns' behavior while in skin-to-skin contact during the first hour after birth and to elucidate the relationship between these hands-on interruptions and the incidence of nipple pain during the first 4 days postpartum.
METHODS: An observational pilot study was conducted at a Baby-Friendly® hospital in Japan from 2016 to 2018. Iterative analysis of video recordings from a larger study of the behavior of newborns while skin-to-skin with their mothers in the first hour after birth found 16 full-term newborns who were born vaginally and that met the inclusion criteria of a midwife's hands-on intervention (HOI) interrupting the infant's progress toward breast self-attachment. The timing of the HOI and the stage of the newborn's progress through Widström's 9 Stages was noted by two research assistants who had been blinded to the medical records. The degree of nipple pain after breastfeeding was self-evaluated by mothers each day during their hospitalization. All data were statistically analyzed.
RESULTS: Interrupting the infant's progressive behaviors in the first hour after birth by midwives' hands-on "help" to breastfeed,  may increase nipple pain during the 4 days after birth. One hundred percent of the mothers reported nipple pain in the postpartum with the highest pain reports occurring on day 4.
CONCLUSION: Interrupting skin-to-skin contact with HOI does not decrease the incidence of nipple pain during the first days postpartum. HOI for newborn infants was not shown to support breastfeeding in the early postnatal period.
Immunopurification of Protease Nexin-2 and .beta. amyloid precursor protein is disclosed. Methods of detecting Protease Nexin-2 and the use of these methods in the diagnosis of Alzheimer's disease and other conditions are also disclosed. Additionally, pharmaceutical preparations including Protease Nexin-2 or modified forms thereof are disclosed. Medical uses for the pharmaceutical preparations are also disclosed. These uses include the treatment and prevention of amyloid plaques in Alzheimer's disease and Down's Syndrome.
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by mutant ataxin-3 with an abnormally expanded polyQ tract and is the most common dominantly inherited ataxia worldwide. There are no suitable therapeutic options for this disease. Autophagy, a defense mechanism against the toxic effects of aggregation-prone misfolded proteins, has been shown to have beneficial effects on neurodegenerative diseases. Thus, trehalose, which is an autophagy inducer, may have beneficial effects on SCA3. In the present study, we examined the effects of trehalose on an SCA3 cell model. After trehalose treatment, aggregate formation, soluble ataxin-3 protein levels and cell viability were evaluated in HEK293T cells overexpressing ataxin-3-15Q or ataxin-3-77Q. We also explored the mechanism by which trehalose affects autophagy and stress pathways. A filter trap assay showed that trehalose decreased the number of aggregates formed by mutant ataxin-3 containing an expanded polyQ tract. Western blot and Cell Counting Kit-8 (CCK-8) results demonstrated that trehalose also reduced the ataxin-3 protein levels and was safe for ataxin-3-expressing cells, respectively. Western blot and total antioxidant capacity assays suggested that trehalose had great therapeutic potential for treating SCA3, likely through its antioxidant activity. Our data indicate that trehalose plays a neuroprotective role in SCA3 by inhibiting the aggregation and reducing the protein level of ataxin-3, which is also known to protect against oxidative stress. These findings provide a new insight into the possibility of treating SCA3 with trehalose and highlight the importance of inducing autophagy in SCA3.
If assigned to this group, participants will take part in weekly 1-hour group sessions twice a week for 3 months. The sessions will be with a trained Community Health Worker that will involve group (5-6 participants) moderate-intensity walking. They will take place at community partner sites during times when all participants can attend. In case of adverse weather, indoor locations are available through community partners. Walks will reflect participant goals and abilities, initially lasting 10 minutes, with 5-minute stretching "warm-up" and 5-minute "cool down" exercises, for a total of 20 minutes. Walk duration will increase by 5 minutes/week to at least 30 minutes with program content delivery time decreasing to accommodate increased walk times within the 1-hour session. Upon completing the 3 months of physical activity sessions, for the next 3 months, they will receive motivational "booster" sessions delivered every other week via phone calls/text messaging.
BACKGROUND: Postoperative delirium is a neurobehavioral disorder that can appear after surgery. It is characterized by an altered level of consciousness and impaired cognitive function. The aim of this study was to evaluate the impact of visual projection of images of relatives or loved ones in patients undergoing cardiac surgery in the immediate postoperative period, and its influence on the incidence and development of postoperative delirium.
METHODS: A randomized, double-blind clinical trial was designed in the immediate postoperative period of adult patients undergoing cardiac surgery. Consolidated Statement of Reporting Trials guidelines were followed. A control group (CG) and an intervention group (IG) were established. In the IG, the patients underwent a visual projection, while the usual unit treatment was carried out with the CG. Sociodemographic, anthropometric, anesthetic, and surgical variables were also recorded. The postoperative delirium assessment scale used was the confusion assessment method for diagnosing delirium in intensive care unit patients.
RESULTS: Information was collected from 104 patients undergoing cardiac surgery. Most of the patients included in the study were men (66.35%) and the most performed surgical intervention was aortic valve replacement (34.62%). In the CG, positive patients in postoperative delirium increased from 19.23% to 25%, while in the IG they decreased from 5.77% to 1.92%. The logistic regression analysis presents a prediction model where the variables that influence the model are gender and group membership, meaning that being female and belonging to the IG significantly reduce the presence of delirium.
CONCLUSION: The projection of visual material reduced the incidence of postoperative delirium in patients undergoing cardiac surgery, although it cannot be established that it is effective as a treatment once the pathology is already established.
Gene therapy using a non-viral vector often requires the administration of large amounts of DNA or RNA dissolved in a solution of relatively small volume. The invention provides a dry powder formulation which contains a lyophilized DNA/liposome complex, a lyophilized RNA/liposome complex, a lyophilized oligonucleotide/liposome complex or a lyophilized protein/liposome complex. The dry powder is suitable for airway delivery or topical administration as an aerosol. The dry powder can be easily reconstituted with water and is active in gene transfer in vitro and in vivo. The potency of gene transfer of the dry powder was at least 50-fold higher than that of a liquid formulation of similar composition. The composition, method of preparation and method of use are described.
FIELD: medicine. SUBSTANCE: plant Salsola collina Pall grown on plantation is gathered and milled additionally and fractionation in screen machines to get form of tea. The latter is infused by conventional procedure and used in cholelithiasis disease. This plant S. collina Pall given to rabbits for 5.5 months which had diet with high level of cholesterol prevents the formation of gall stones. EFFECT: decreased incidents of cholelithiasis disease in health human and in patients with chronic cholecystitis, postcholecystectomy syndrome, after conservative gall stones dissolution with bile acid preparations or chemical solvents, enhanced prophylaxis of gall stone formation. 3 tbl
The Sham Group (SG) will follow a 6-week sham intervention protocol with three weekly sessions (Monday, Wednesday, and Friday) of 5 cycles of 6 minutes per session with an FiO2 of 21% using the MITOVIT® Hypoxic Training System (COMMIT GmbH, Salzgitter, Germany). Participants will be asked to sit and breath normally in each exposure. An attendance checklist will be used to monitor compliance with the placebo intervention.
Participants will be treated for an index procedure using Roxwood Medical device(s) as prescribed by the Investigator SOC on Day 0. All devices will be used in accordance with the Instructions for Use (IFU). Participants are to be administered SOC acetylsalicylic acid (ASA) and/or anti-platelet medications orally per physician discretion prior to the index procedure. Administration of an intravenous injection of heparin during the index procedure will also be at the discretion of the Investigator per Institutional SOC.
A network system for review and analysis of computer encoded microscope slides and specimens which were originally computer encoded from a microscope (attached via an encoder device to a local computer site), during an initial examination. The encoding includes parameters of viewing locations and events of interest on the slide, with such information being stored on a networked file server. The encoding also includes information regarding the manner in which the initial examination was conducted, for quality control purposes. The computer encoded information is retrievable at all remote locations of the network (either local or connected via modem) for supervisor review or for pathologist analysis. The network is further constituted by microscope sites having similar computer encoding devices attached thereto, which function, in this aspect, as computer terminals of the network. For enhanced analysis, the computer terminals have direct access to patient background information, e.g., such as from an HIS (hospital information system) for simultaneous slide analysis review in relation to the medical history of the patient. For diagnostic support, the computer terminals are networked with an on-line library of cell type images for comparison with the slide being examined. Slide diagnosis is either directly with the original slide on the microscope or with a scanned image of the slide stored in the network server or CD-ROM and retrieved on the computer terminal. The microscope is optionally motor driven, with computer control, to re-scan slides or slide images only at designated sites.