The covid-19 coronavirus has killed more than 5,129,829 people, globally, out of about 255,098,687 infected. About 10 million persons died from cancer in 2020, with 19.3 new cases diagnosed. About 409,000 persons died of malaria in 2019. And none of these diseases made the WHO's list of top 5 deadly diseases of 2019. Modern medicine has made tremendous progress in the prevention and treatment of disease, but the crashing of the covid-19 coronavirus and the extremely high burden of the top deadly diseases point to the urgency of radical and totally disrupting inventions in medicine. Indeed, to effectively overcome the current burden of deadly diseases we need an agile platform with exponentially better efficacy and predictability. The world is in dire need of a new medicine platform that totally and radically disrupts the current healthcare systems and the traditional ways of preventing and treating disease. The present invention does that. The present invention uses transformed microbes, targeted to one or more mucosal surface, to prevent and treat just about any disease of importance. The current means of disease prevention relies on vaccines. As we have seen from countless failures and booster shots, vaccines have extreme limitations and increasingly fewer following. Firstly, vaccine development is unpredictable, lengthy and costly. An important lesson of the covid-19 pandemic is that waiting for several months or years to develop a vaccine, while a disease ravages the population, is unacceptable. Also, protection that is dependent on a vaccine and frequent booster shots can only find a market in despair. We have also seen complete failure of vaccines in a lot of important diseases such as HIV and cancers. The current invention presents a method of preventing disease using transformed microbes. It is more effective than vaccines because it is delivering significantly more antigens, than vaccines, in their native conformation, directly to antigen presenting cells of the immune system. It takes advantage of the natural design of the immune system, to send the messengers that the immune system pays the closest attention to (microbes), to deliver a clear and detailed message (relatively large amounts of antigens in their native conformation) to the proper receiving cells of the immune system (antigen presenting cells). This method not only prevents disease, it cures disease. The current means of treating diseases relies heavily on medications and surgical intervention. The costs and adverse effects of drugs and the primitivity of surgical intervention are self-evident limitations of "modern medicine". The current invention presents a method of treating disease using transformed microbes. Pathogen peptides, cancer neoantigens, and other therapeutic targets are transformed in microbes in such a manner that the microbes express the gene products in a manner as to target a specific therapeutic pathway. For example, the genes encoding all lung cancer neoantigens are transformed into a microbe, as chimeric proteins with surface antigens of an endemic pathogen for which the immune system is likely primed, in a manner that expresses the gene product in the microbial membrane. The microbes with their transmembrane trough of antigens are introduced to one or more mucosal surface, e.g., the mucosae of the GI tract, vagina, or respiratory tract. No needles. No shots. No scary tales. It is a hundred percent about guiding the body to prevent and treat diseases, by itself, the way nature intended, with bacteria and yeasts wearing the white coats. Developing transformed microbes can take days to weeks, compared to the years and decades that it takes to develop vaccines and small molecule drugs. Transformed microbes cost a lot less to develop and can be manufactured anywhere in the world in a matter of days. The current invention will greatly reduce or eliminate the need for several diagnostic and medical procedures, vaccines, and drugs. It will save lives, ameliorate pain and suffering from disease and change economies - without a single shot.