anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation (137Cs, 0.98 Gy/min) at a total dose of 6.8 Gy. Radiation exposure led to delayed active growth, leukopenia, and lymphopenia for over 1 year during the post-radiation period. The death of irradiated males and females occurred significantly earlier than in control group animals. Median lifespans in the experimental group were 35-38% lower than in the control group (p<0.001). Ionizing radiation exposure led to the early development of hair depigmentation, cachexia, and the development of aging-associated diseases. In irradiated mice, oncological pathology constituted 30-35% in the mortality structure, which is twice as often as in the control group. The developed model can be used to study the pathogenesis of accelerated aging under radiation exposure and the search for means of its prevention and treatment.
The invention discloses a mild facial cleanser, which is prepared from the following raw materials by weight: 5-15 parts of a surfactant, 3-10 parts of nano-collagen, 2-8 parts of pearl hydrolysate liposome, 5-12 parts of a plant extract, 0.05-0.2 part of a moisturizing agent, 0.008-0.1 part of essence, and the balance deionized water. The plant extract is prepared from, by weight part, 5-20 of seaweed, 3-15 of green tea, 5-12 of aloe, 3-10 of peach blossom, 2-8 of licorice, 5-10 of Polygonatum odoratum, and 6-18 of chamomile. The facial cleanser product provided by the invention shows weak acidity, and has small irritation to skin. The contained pearl hydrolysate liposome component has whitening, moisturizing and anti-aging effects. The nano-collagen can replenish nutrition to skin, and makes the cleaned face shiny and elastic. The added plant extract contains green tea, aloe, chamomile and other natural ingredients, not only has the anti-inflammatory and acne removing effects, but also can resist wrinkle and tender skin.
Plastics, encompassing a wide range of polymeric materials, and their downstream products (micro- and nanoplastics, MNPs) are accumulating in the environment at an alarming rate, and they are linked to adverse human health outcomes. Considering that ingestion is a main source of MNPs exposure, the impact of plastics is particularly relevant towards intestinal inflammation and inflammatory bowel disease (IBD). However, the study of MNPs has been limited by obstacles relating to sample collection, preparation, and microplastics analysis based on optical microscopy and chemical analysis, which we detail in this review alongside potential solutions. We summarize available data on human exposure to MNPs and overall health outcomes, with particular focus on data pertaining to intestinal inflammation, microbiome perturbations, and related outcomes. We include ecologic perspectives, and human, in vitro, and animal model studies. We discuss the way forward in MNPs and IBD research, including knowledge gaps and future research.
Epilepsy is a common neurological disease. Increasing evidence has highlighted the role of miRNAs in the molecular mechanisms underlying the development of neurological diseases such as epilepsy. In this study, we established a lithium chloride-pilocarpine epilepsy mouse model, performed miRNA sequencing of hippocampal tissue samples, and compared the obtained miRNA expression profile with that of normal control mice to determine differences in expression levels. We found that 55 miRNAs were differentially expressed in status epilepticus mice compared with normal control mice, with 38 upregulated and 17 downregulated miRNAs. Through subsequent analysis of the five downregulated miRNAs (mmu-let-7a-1-3p, mmu-let-7a-2-3p, mmu-let-7c-5p, mmu-let-7d-5p, and mmu-let-7e-5p) with the most significant differences in expression, the key pathways involved included the MAPK signaling pathway and focal adhesion, among others. Therefore, we believe that let-7 family miRNAs may be potential therapeutic targets for epilepsy.
Women with ≥ 18 with abnormal bleeding (post-menopausal menorrhagia or metrorrhagia), managed at bleeding clinic. Each women will undergo an hysteroscopy and a hysterosonography and will be her own control.
The patients in the Control Group underwent to following interventions: 1. General Rehabilitation 2. Specific wrist rehabilitation performed by physiotherapist.
Focused Acceptance \& Commitment Therapy (FACT): FACT is a brief type of cognitive behavioral therapy that helps patients reduce disability through increased acceptance, reconnection with values, and reduced unhelpful control/coping strategies. Patients randomized to the intervention group received FACT per the study manual, delivered by an integrated Behavioral Health Consultant (BHC). Patients had one individual visit (30 minutes) and three consecutive weekly group visits (one hour) followed by a booster visit two months later. These classes (group visits) were rolling, not cohort-driven, meaning new and returning patients will be attending together. After the individual BHC visit and each class, patients had behavioral "homework" to complete.
Nursing students in this group will be given sexual health training. The training will last for 4 weeks. The training is 16 hours in total. During the training, students will learn the PLISSIT model and evaluate cases involving using this model. Questionnaire will be applied before the training, immediately after the training and 3 months after the training.
BACKGROUND: There has been a greater focus in recent literature proposing air to be a superior medium to saline in tissue expanders. This study aims to review the literature and assess the quality of data on the efficacy and safety of air as an alternative medium to saline in tissue expanders, in the setting of postmastectomy two-stage reconstruction.
METHODS: A systematic review regarding air inflation of tissue expanders was conducted using PubMed, Embase, Cochrane Library, and Web of Science. The methods followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Three reviewers separately performed data extraction and comprehensive synthesis.
RESULTS: A total of 427 articles were identified in our search query, of which 11 met the inclusion criteria. Three pertained to inflation with room air, and eight pertained to inflation with CO2 using the AeroForm device. They were comparable to decreased overall complication rates in the room air/CO2 cohort compared to saline, although statistical significance was only observed in one of five two-arm studies. Investigating specific complications in the five two-arm studies, significantly lower rates of skin flap necrosis were only observed in two CO2-based studies. Studies rarely discussed other safety profile concerns, such as the impacts of air travel, radiation planning, and air extravasation beyond descriptions of select patients within the cohort.
CONCLUSION: There is insufficient evidence to suggest improved outcomes with room air inflation of tissue expanders. Further work is needed to fully characterize the benefits and safety profiles of air insufflation before being adopted into clinical practice.
A novel compound having excellent activation to glucokinase is provided to prevent and treat diabetes, the complication of diabetes or obesity by activating the glucokinase. An indole compound having glucokinase activation is denoted by the chemical formula 1. A pharmaceutical composition for the glucokinase activation comprises a compound of the chemical formula 1, its pharmaceutically allowable salt or isomer and pharmaceutically allowable carrier. The diseases caused by the decrease of glucokinase activation is diabetes, the complication of diabetes, or obesity. The diabetes is type one diabetes or type two diabetes. The complication of diabetes is neurological disease, hyperlipidemia, hypertension, retinopathy or renal failure.
The invention discloses application of Gypensapogenin A in preparing a medicine for preventing human fungi, belonging to the medicine field. Gypensapogenin a has strong inhibiting functions on trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that Gypensapogenin A can be used as a compound for resisting human fungi, and can be applied for preparing relative medicine. The application of Gypensapogenin A in preparing the medicine for preventing human fungi, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the human fungus inhibiting activity of Gypensapogenin A is extremely strong, so that no possibility for providing any prompt by other compounds exists. Gypensapogenin A has outstanding actual characteristics. Meanwhile, Gypensapogenin A has outstanding progress when being used for preventing and treating human fungus infection.
NEW MATERIAL:Polypeptides containing an amino acid sequence represented by the formula in its molecule. USE:A preventive and treating agent for herpes simplex virus (HSV)-infectious diseases. PREPARATION:For example, following the infection of Vero cells (African green monkey nephrocyte) with herpes simplex virus type-1 (HSV-1 type) Miyama strain, culturing the infected cells at 37 deg.C, subsequently separating virus by conventional method, extracting the DNA thereof, treating the extracted DNA with a restriction enzyme, binding the treated DNA to a vector and transforming colibacilli using the recombinant DNA, transformed colibacilli are isolated and cultured. The cultured transformed colibacilli are subjected to a cloning using a base segment of gB gene such as of a known HSV-1 type KOS strain as a DNA probe and positive clones are selected in order to extract DNA therefrom. The extracted DNA is treated with a restriction enzyme and bound to a vector to transform its host. The resultant transformant is cultured, thus obtaining the objective polypeptide containing an amino acid sequence of the formula.
<P>PROBLEM TO BE SOLVED: To provide a detergent deodorizing compounding agent which uniformly dissolves in an aqueous solvent even when a zinc compound hardly soluble in water is used as a deodorizing component, has an action to remove the odor component present in a detergent as an additive, and is low-cost and safe to the human body, and a detergent composition.  <P>SOLUTION: The detergent deodorizing compounding agent comprises a mixture of zinc carbonate and/or zinc oxide and at least one amino acid selected from the group consisting of glycine, alanine, phenylalanine, a glutamate, and sarcosine. The weight ratio in the combined use of the zinc carbonate and/or zinc oxide to the amino acid is in the range of 1:2 to 1:50. The deodorizing compounding agent is preferably in the form of an aqueous solution. The detergent composition is obtained by incorporating the above deodorizing compounding agent into a detergent.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Vibrio vulnificus is a halophilic gram-negative bacillus that can cause fulminant septicaemia in immunocompromised patients. A 67-year-old man who was immunosuppressed as a result of cytotoxic chemotherapy presented with a brief history of fever, lethargy, myalgia, and reduced oral intake. He had recently travelled to the beach to consume seafood. His blood pressure was 81/47 mm Hg, necessitating fluid resuscitation followed by inotropic support and admission to the intensive care unit. His blood culture was positive for curved gram-negative bacilli. The isolate was oxidase-positive and produced an acid butt with an alkaline slant in triple sugar iron agar. Matrix-assisted laser desorption ionization-time of flight mass spectrometry conclusively identified the isolate as V. vulnificus. Intravenous ceftazidime plus ciprofloxacin were administered, and by the fifth day of admission, he was successfully transferred out to the general ward. In total, the patient completed a 14-day course of antibiotic therapy.
Patients are assigned to using the Cooral® MCD after radiotherapy for 60 min. along with general oral care (GOC). The MCD will be placed into the subjects' mouth and remain intraorally for 60 minutes. After each fraction, i.e. session of RT, the subjects insert the MCD inside their mouth and can start the Cooral ® thermostat system themselves when they feel comfortable. The stopwatch will be started by the patient as soon as thermostat is running. The patient is asked to write down the starting and the stopping time of the 60-minute procedure. Thereafter the subject will receive a questionnaire to record the tolerance for the device. Patients will be also informed about standard of care (SOC) that should be regularly performed.
We propose a state-of-the-art deep learning approach for accurate electrocardiogram (ECG) signal analysis, addressing both waveform delineation and beat type classification tasks. For beat type classification, we integrated two novel schemes into the deep learning model, significantly enhancing its performance. The first scheme is an adaptive beat segmentation method that determines the optimal duration for each heartbeat based on RR-intervals, mitigating segmenting errors from conventional fixed-period segmentation. The second scheme incorporates relative heart rate information of the target beat compared to neighboring beats, improving the model's ability to accurately detect premature atrial contractions (PACs) that are easily confused with normal beats due to similar morphology. Extensive evaluations on the PhysioNet QT Database, MIT-BIH Arrhythmia Database, and real-world wearable device data demonstrated the proposed approach's superior capabilities over existing methods in both tasks. The proposed approach achieved sensitivities of 99.81% for normal beats, 99.08% for premature ventricular contractions, and 97.83% for PACs in beat type classification. For waveform delineation, we achieved F1-scores of 0.9842 for non-waveform, 0.9798 for P-waves, 0.9749 for QRS complexes, and 0.9848 for T-waves. It significantly outperforms existing methods in PAC detection while maintaining high performance across both tasks. The integration of aforementioned two schemes into the deep learning model improved the accuracy of normal sinus rhythms and arrhythmia detection.
The invention belongs to the medical technical field and relates to applications of capric acid diethanolamide and analogs thereof, in particular to applications of capric acid diethanolamide and analogs thereof such as lauroyl diethanolamide in the aspect of promoting the absorption of macromolecular substances. The structural general formulas of the capric acid diethanolamide and analogs thereof such as lauroyl diethanolamide which are related to by the invention are shown in the picture (I and II) below. In the picture II, the R group can be C1-12 linear alkyl or branched alkyl. The compounds have stable structure, and can be used to prepare all types of clinically acceptable preparations by combining with pharmaceutical auxiliary materials. The result of the test of promoting the absorption of macromolecular substances shows that the compounds have higher activity of promoting the absorption of macromolecular substances and have the advantages of strong activity, low drug dosage and the like. The capric acid diethanolamide and analogs thereof can be used in the administration penetrating agent of macromolecular substances. The formula I and the formula II are shown in the specification.
PURPOSE: To obtain a skin cleaning agent for face washing, massaging, etc., having excellent waste-removing effect and giving good feeling to the skin. CONSTITUTION: This cleaning agent contains 0.01-5wt.% of spherical resin powder (e.g. spherical polyethylene) and 0.01-5wt.% of fiber (e.g. nylon wool). The weight ratio of the fiber to the spherical resin powder is preferably 1:(25-2.5). Preferably, the diameter of the spherical resin powder is about 50-300μm and the length of the fiber is about 0.1-5mm. The agent is preferably further incorporated with a granular substance (e.g. fine crystalline cellulose). The agent is properly compounded with humectant, thickener, drug component, colorant, dispersing agent, perfumery, etc., in addition to the above components. The addition of the fiber causes the entanglement of the waste with the fiber to promote the separation of the waste from the skin and the fiber softens the feeling to the skin by preventing the direct contact of the scrubbing agent to the skin.
Disclosed herein are improved nanozymes for targeting RNA. The disclosed nanozymes are synthesized using recombinant RNase A with site-specific cysteine- substituted mutations that can be covalently functionalized with a length-tunable multi-thiol tether and then loaded onto gold particles through multiple gold-sulfur bonds. This new RNase A loading mechanism is site specific, and it allows high- density loading of alkylthiol modified DNA oligonucleotides. The disclosed nanozymes can also include additional capturer strands and/or involve DNA- recombinant-RNase-A unibodies to further increase the nanozyme's enzymatic activity and target selectivity. Also disclosed are functional on-off switchable nanozymes to control nanozyme activity. In some embodiments, the disclosed nanozyme are core-free hollow forms. The removal of the inorganic nanoparticle cores from nanozymes can effectively eliminate the potential long-term toxicity induced by the core, and also creates a cavity for loading and delivery of small molecule drugs.
Longterm elevation of the intracellular Na /K+ ratio inhibits macromolecule synthesis and proliferation in the majority of cell types studied so far, including vascular smooth muscle cells (VSMC). We report here that inhibition of the Na+,K+ pump in VSMC by ouabain or 1 hr preincubation in K+-depleted medium attenuated apoptosis triggered by serum withdrawal, staurosporine or okadaic acid. In the absence of ouabain, both DNA degradation and caspase-3 activation in VSMC undergoing apoptosis were insensitive to modification of the extracellular Na+/K+ ratio as well as to hyperosmotic cell shrinkage. In contrast, protection of VSMC from apoptosis by ouabain was abolished under equimolar substitution of Na+o with K+o, showing that the antiapoptotic action of Na+,K+ pump inhibition was caused by inversion of the intracellular Na+/K+ ratio. Unlike VSMC, the same level of increment of the [Na+]i/[K+]i ratio caused by 2-hr preincubation of Jurkat cells with ouabain did not affect chromatin cleavage and caspase-3 activity triggered by treatment with Fas ligand, staurosporine or hyperosmotic shrinkage. Thus, our results show for the first time that similarly to cell proliferation, maintenance of a physiologically low intracellular Na+/K+ ratio is required for progression of VSMC apoptosis.
Participants, upon diagnosis with high risk DCIS, will be offered 2 doses of pembrolizumab injected intralesionally (IL) 3 weeks apart (+/- 1 week) with surgery 3 weeks (+/- 2 weeks) after the 2nd dose. The participant will then undergo the surgical treatment as determined by the surgeon and the participant (partial mastectomy or mastectomy).
Transanal irrigation (TAI) is performed using the irrigation bag, electronic irrigation system, or balloon catheter with syringe. TAI is performed with up to 2000 ml tap water every 24-48 hours (3-7 times per week) over the course of 6 months.
A randomized, controlled, cross-over study designed to examine the PPGR to peas will be conducted at the I.H. Asper Clinical Research Institute in Winnipeg, Manitoba. The study will be divided into 2 groups of 24 healthy volunteers each. In Group 1, eligible participants who have provided consent will be asked to attend 6 clinic visits in a fasted state. Participants will be given white bread at their first and last visits, peas with rice at 3 visits and rice at 1 visit. At each visit participants will provide 7 blood samples via finger poke, 6 questionnaires about their appetite and a questionnaire about the acceptability of the test food. Each visit will last approximately 2.5h and be separated by 3-10 days. Group 2 will undergo the exact same study procedures as group 1, but rice will be replaced with potato.
PURPOSE:To provide a low-cost non-toxic tranquillizer composed of fructose and additives for drug preparation. CONSTITUTION:Fructose is mixed with an additive for drug preparation (e.g. excipient, binder, diluent, etc.) to obtain the titled agent. Stress-recovering effect was observed by administering fructose orally to an experimental mouse immediately after application of stress, and tranquillizing effect was observed when fructose is administered to the mouse before application of stress, and applying stress to the mouse during the administration of fructose. The stress was prevented, suppressed or recovered in the experiment of the anti-stress effect from the praxiological (rectal temperature, grip strength and trunk tone), biochemical (blood ammonia level) and immunological (spleen weight and thymus weight, etc.) viewpoints.
There is provided in accordance with practice of this invention a process for separating protein fractions from a solution containing proteins and an apparatus for practicing the process. The process and apparatus involve withdrawing from a suspension tank a portion of the suspension contained therein to form a recycle stream. The withdrawn suspension forming the recycle stream contains particles of a selected protein fraction precipitated from a solution containing proteins. Fresh protein solution comprising proteins of the selected protein fraction is mixed into the recycle stream to form a mixed recycle stream. At least a portion of the selected protein fraction proteins in the fresh protein solution precipitate onto previously precipitated selected protein fraction particles suspended in the mixed recycle stream. The mixed recycle stream is introduced back into the suspension tank. A portion of the suspension is withdrawn from the suspension tank in a product stream and precipitated, selected protein fraction particles are recovered from the product stream.
BACKGROUND: Ultrapluse CO2 fractional laser technology has emerged as an effective treatment for scar management. However, one drawback of this modality is the pain caused during the procedure. This study aims to explore the efficacy and safety of dezocine (DZC) as preemptive analgesia for reduction of pain induced by ultrapulse CO2 fractional laser treatment for acne scars.
METHODS: The study cohort included 78 outpatients with acne scars between February and April 2023. Patients were randomly assigned into three groups with intravenous injection (iv) of DZC prior to laser treatment: (1) control, iv of saline; (2) DZC group 1 (DZC_1), iv of DZC at 0.15 mg/kg; and (3) DZC_2, iv of DZC at 0.20 mg/kg. After 30 min, one session of ultrapulse CO2 fractional laser treatment on acne scars was performed. Hemodynamics, visual analogue scale (VAS), and anxiety visual analog test (AVAT) were monitored prior to, during, and after the procedure.
RESULTS: Operative success rates for patients in the control, DZC_1, and DZC_2 groups were 34.6%, 84.6%, and 100%, respectively. DZC administered with either dosage significantly reduced the VAS and AVAT scores of patients in treatment groups as compared with the subjects in the control group during the course of ultrapulse CO2 fractional laser treatment. Patients in DZC_1 and DZC_2 groups did not show any significant difference in hemodynamic parameters, VAS, and AVAT scores. Temporary adverse effects such as nausea and dizziness were observed in some subjects after treatment; the symptoms were quickly dissolved after a rest in supine position.
CONCLUSIONS: DZC as preemptive analgesia could effectively reduce pain and anxiety induced by ultrapulse CO2 fractional laser treatment in patients. This study provided an option of preemptive anesthesia to minimize the pain and discomforts associated with laser treatments in clinical practices.