anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to the field of health products, in particular to a health medicinal pillow, which solves the problems of the existing medicinal pillow of unreasonable material selection, poor curing effect, long curing period and single disease. The pillow includes a pillowcase and a pillow, and the pillow is internally wrapped with a Chinese medicine bag. The Chinese medicine bag consists of common selfheal, sickle senna seed, flagleaf, Acronychia pedunculata, chrysanthemum, parasite scurrula, multiflower knotweed, cortex eucommiae, hooked uncaria, Chinese honey locust, rhizoma atractylodis, ageratum, mint, lycopus herb, forune eupatorium herb, folium perillae acutae, angelica, chuanxiong rhizome, white peony, red peony, rehmannia root, multiflower Knotweed root, achyranthes root, pawpaw, earthworm, silkworm with botrytis, notopterygium root and wild celery. The present invention with reasonable prescription, obvious curing effect and no toxic side effect is used for curing hypertension, insufficiency of cerebral blood supply, coronary heart disease, apoplectic hemiplegia and arthralgia. After being used for a long time, the present invention can strengthen the antiviral ability of human body, protect the health and prolong the life. The present invention mixes the raw materials with different functions, thus overlapping various curing effects and playing a role together.
Rufinamide tablet USP is a triazole derivative structurally unrelated to currently marketed antiepileptic drugs (AEDs). Rufinamide USP has the chemical name 1-[(2,6-difluorophenyl)methyl]-1 H-1,2,3-triazole-4 carboxamide. It has an empirical formula of C 10H 8F 2N 4O and a molecular weight of 238.2. The drug substance is a white to off white colour powder. Rufinamide is slightly soluble in tetrahydrofuran and in methanol; very slightly soluble in alcohol and in acetonitrile; practically insoluble in water.   


Rufinamide tablet USP is available for oral administration in film-coated tablets, scored on both sides, containing 200 and 400 mg of rufinamide. Inactive ingredients are colloidal silicon dioxide, corn starch, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, methocel K 3 Premium LV hydroxypropyl methyl cellulose, microcrystalline cellulose and sodium lauryl sulfate. The film coating contains hypromellose, iron oxide red, polyethylene glycol, talc, and titanium dioxide.
Treatment as usual from baseline to 12 week follow-up assessment. Then receive access to Coping Coach intervention after 12 week follow-up for use (self-guided, with email reminders) over the next 6 weeks.
A portable pupillometer includes a main body, an image processing module and a display module. The main body is provided with a visible light source module, an invisible light source module and an image capturing module. The image capturing module is configured to capture invisible light image data of a tested pupil. The image processing module is electrically connected to the image capturing module. The image processing module is configured to perform a deep learning algorithm to select a piece of pupil contour information from the invisible light image data and output a pupil characteristic parameter associated with the pupil contour information. The display module is electrically connected to the image processing module to display the pupil characteristic parameter.
Sleep and mental health have a strong relationship. There is a lack of training in Sleep Medicine for Psychiatrists. Sleep problems often accompany mental health issues, especially in children and adolescents on inpatient psychiatry units. Recognizing common sleep disorders is important in these settings. It is also important to involve pediatric sleep specialists when needed. This article addresses common sleep disorders observed in inpatient child and adolescent psychiatry units and outlines optimal management strategies.
The invention is concerned with a kind of medicine for curing leucoderma with melanin regeneration. It relates to balloonflower root, ducksmeat, tribulus terrestris, red sage root, angelica, chuanxiong rhizome, psoralea fruit, astragalus root in proportion. It takes effect quickly, just for 1 to 4 days, and it has short period of treatment, only for 1 to 2 times, and it has high cwith 84.2 percent of whole curative ratio and it is difficult to recurrence. It can reduce the blood viscosity and flowing property, improve microcirculation, enhance content of ceruloplasmin, reduce humoral immunity and enhance cellular immune function to promote melanin regeneration of skin. It has unconspicuous side reaction and effective safety for clinic application with low cost. It is easy for preparation to lighten economy burden of sick.
The present teaching relates to surgical procedure planning. In one example, at least one 3D object contained in a 3D volume is rendered on a display screen. The at least one 3D object includes a 3D object corresponding to an organ. First information related to a 3D pose of a surgical instrument positioned with respect to the at least one 3D object is received from a user. A 3D representation of the surgical instrument is rendered in the 3D volume based on the first information. Second information related to a setting of the surgical instrument is received from the user. A 3D treatment zone in the 3D volume with respect to the at least one 3D object is estimated based on the first and second information. The 3D treatment zone in the 3D volume is visualized on the display screen. Controls associated with the 3D representation of the surgical instrument and/or the 3D treatment zone are provided to facilitate the user to dynamically adjust the 3D treatment zone via the controls.
Prominent ears (PEs) are the most frequent congenital external ear deformity, occurring in ∼5% of the population. Although the deformity does not usually cause functional difficulties, it can significantly affect the patient's psychological and social health. The authors aim to present the Welsh experience of pinnaplasty, reviewing our outcomes and complications. A retrospective cross-sectional study was performed of all patients undergoing pinnaplasty in Morriston Hospital, Swansea, Wales. We represent the tertiary plastic surgery referral unit across Wales. We included all patients undergoing pinnaplasty between 2015 and 2022 inclusive. We excluded patients undergoing revision procedures or those who had no follow-up. Over the 7-year period, 236 pinnaplasties were performed and 203 were included in the analysis. Ninety-six percent of cases were performed using a cartilage-sparing approach, which represents the mainstay in our unit. The mean follow-up length for our cases was 12 months. Revision procedures were required in 4% of cases. Three hematomas (1.5%) and one (0.5%) wound dehiscence due to infection were recorded and required a return to the operating room. Suture extrusion was noted in 5% of cases (10 patients); 4.5% (9) cases were affected by either hypertrophic or keloid scarring. Across the United Kingdom, cosmetic procedures have come under scrutiny, namely, because of a difficult economic climate. In the era of tight fiscal control in health care, it is pertinent to analyze the outcomes and performance metrics of our operations regularly, thus aiding in the development of an established evidence base to advocate for our respective patients.
PROBLEM TO BE SOLVED: To provide a cosmetic which is excellent in antimicrobial properties, ultraviolet absorption, prevents skin roughening and malting and keeps skin beautiful and provide its production process. SOLUTION: This cosmetic contains yucca extract and saponin, flavone and resveratrol are contained in the yucca extract. If the cosmetic is calculated as 100wt.%, the content of saponin, flavone and resveratrol is 0.001-5wt.%. The objective cosmetic is produced by chipping at least one of the roots or stems of yucca and drying, or drying and chipping them, crushing them into a powder, then soaking the powder in an ethanol-water mixed solvent thereby preparing the yucca extract. Subsequently, the yucca extract is formulated to a cosmetic. The ethanol-water mixed solvent contains 75-95wt.% of ethanol.
OBJECTIVES: I. Determine the safety of topotecan in combination with fludarabine, cytarabine, and filgrastim (FLAG) in patients with poor prognosis acute myeloid leukemia, myelodysplastic syndrome, or recurrent or refractory acute lymphocytic leukemia. II. Determine the maximum tolerated dose of topotecan in the FLAG regimen in these patients. III. Assess the complete remission rates in patients treated with this regimen.

OUTLINE: Patients with complete response proceed to further therapy according to age. 65 and under: Patients receive etoposide by IV continuously for 5 days, cytarabine IV over 2 hours every 12 hours for 4 days, and filgrastim (G-CSF) subcutaneously. Peripheral blood stem cells (PBSC) are then harvested. Patients then receive oral busulfan every 6 hours on days -7 to -4 and etoposide IV over 10 hours on day -3. PBSC are reinfused on day 0. Over 65: Patients receive oral isotretinoin and vitamin E daily. Treatment continues in the absence of disease progression or unacceptable toxicity. Patients are followed every month for 1 year and then every 3 months thereafter.

PROJECTED ACCRUAL: A total of 15 patients will be accrued for this study within 3-4 years.
The present invention relates to a composition for preventing allergic rhinitis and for treating nasal obstruction, which comprises a mixture of extracts Salvia plebeia R. Br., Ulmus davidiana var. japonica, Clerodendrum trichotomum Thunb. ex Murray and Eleutherococcus senticosus (Rupr. & Maxim.)Maxim. as a mixture of naturally occurring materials, and is effective for anti-inflammation, particularly for improving rhinitis, allergic rhinitis, sinus infection and rhinitis-derived nasal obstruction.
The present invention relates to the composition of cellular carriers based on dendric polymers and showing adapted/changing solubility and complementarity to certain lipid membrane receptors including to those of the cells. These dendric polymers will be used as carriers for the transport of bioactive molecules to liposomes and bio-cells. More precisely, the bioactive molecules included in the interior of the nanocavities of these dentric polymers are transported along with their carriers through the membranes. For the induction and facility of the transport of bioactive molecules to these polymers, there are introduced functional groups, which are complementary to membrane receptors (folic, hydrocarbon groups etc). According to another mode, the active under transport molecules are connected in a homopolar mode to the dendric polymers presenting the above-mentioned properties. The same molecular transport characteristics are conserved when the aforementioned dendric polymers are connected either in a homopolar or in a non-homopolar mode to liposomes. In the last case, the liposomes are characterised as dendric liposomes encapsulating bioactive molecules either in the liposomic or dendric sections of the nanocavities.
PROBLEM TO BE SOLVED: To widen a therapeutic range and to make a prescription according to a symptom like the use of Chinese medicines by forming a recessed air chamber on the skin sticking face of a thermal sticking body having a heating element and a galenical, and causing a convection action in the air chamber with heat. SOLUTION: A recessed air chamber 3 is formed at the center section of a bottom face, which is to be kept in contact with the skin 2, of a layer 1 containing a heating element, and a layer 4 containing a galenical is stuck to the upper wall of the air chamber 3. A sticking agent 5 is provided on the layer 1 to stick the layer 1 to the skin 2. An air-permeable nonwoven fabric is preferably embedded in the layer 1. It is effective to use the layers 1, 4 in two layers, however they may be mixed into one layer. A heating composition containing a porous natural mineral generating heat under the existence of air, e.g. vermiculite, is used for the heating element. The air chamber 3 is heated by the layer 1 to cause air convection, the absorption of the galenical component from the skin 2 is promoted, and a therapeutic effect can be improved.
Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced; immune responses that result in prophylaxis and/or therapeutic treatments are preferred. Antigen and adjuvant activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens and adjuvants which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a liquid formulation, patches or other medical devices may be used to deliver antigen for immunization.
Art Therapy is used across the Military Health System (MHS) as part of interdisciplinary treatment programs with great success, but there is limited research on how this art therapy works. Therefore, the purpose of this research is to learn about the effects of art therapy on emotional expression and regulation in service members as well as the impact of art therapy on brain systems. If a participant chooses to be in this study he or she will attend ten sessions over a period of ten to twelve weeks. The first session and tenth sessions of this research study will include interviews and self-assessment questionnaires to collect information on a variety of symptoms, experiences, and personality traits, and a magnetic resonance imaging (MRI) scan. During the MRI scan, participants will be asked to perform a task where they will be shown a series of neutral and negative images. These sessions will be about 2.5 to 3 hours. The sessions two through nine will include a one-hour art therapy sessions with a certified art therapist. The art therapy sessions are also considered research interventions.

There is the risk that participants may experience increased psychological or emotional distress or frustration when discussing traumatic events during either the art research intervention sessions or during the questionnaires or interviews. Participants may experience a reduction in symptoms associated with posttraumatic stress (PTS), mild traumatic brain injury (mTBI), and/or other psychological heath disorders through the art therapy process. However, there is no guarantee that participants will benefit from being in this research. As an alternative to this research, participants can talk to your physician about art therapy or other therapeutic options.
1 in 3 Canadian women experience IPV in their lifetimes. Over time, chronic stress of living in an abusive relationship has been shown to contribute to depression, anxiety and PTSD. Safety planning to reduce the risk of physical and emotional harm in abusive situations is one of the most widely recommended interventions for women in abusive relationship. However, fewer than 1 in 5 Canadian women access support from violence services to assist them in safety planning. Rural, Aboriginal, racialized, immigrant, sexual minority women and women who prioritize their privacy face particular barriers to accessing information and support for safety planning.

We adapted an interactive, online safety decision aid (SDA) recently developed and tested in the U.S. (Glass and colleagues, 2010) so that it applies to diverse groups of Canadian women, and extends the focus on emotional safety. The tool was revised based on a pilot testing for content and usability with 30 women (15 women who had experienced IPV and 15 service providers/experts). In this study, we test the effectiveness of this new tool, called "I CAN Plan 4 Safety" in a sample of 450 women from 3 provinces (ON, BC, New Brunswick). Women will be randomly assigned to complete either the personalized online safety decision aid (intervention) or an online tool which contains general risk and safety information (usual care control). Both tools are located on a confidential, password protected website. After initial completion of the online tools, they will be asked to login to the websites 3, 6 and 12 months later to complete standard outcome assessments. Women may access the information and resources in the online tools at any time for a 12 month period after they enrol in the study.
In the study, we aimed to investigate the activity of nanoformulations containing 5-fluorouracil and polymer-magnetic hybrids bearing membrane-penetrating and ligand-receptor-recognizing agents against colorectal cancer cells. The formation and characterization of iron oxide particles covered with polymeric shells comprising lithocholic acid and folic acid moieties are presented. The efficiency of nanoformulations combined by the simple mixing of low doses of 5-fluorouracil with the obtained hybrids was demonstrated against DLD-1 and HT-29 colon cancer cells. The most pronounced cytotoxic potential against HT-29 cells was observed in the cases of particles based on block and randomly arranged copolymers functionalized by FA motifs with depletion of viable cells by approximately 50 % compared to control cells and cells treated by 5-FU applied in free form. In the case of the DLD-1 cell line, the percentage of viable DLD-1 cells decreased by about 30 to 40% after treatment with the block and randomly arranged copolymer decorated by FA-moiety, when compared to 5-FU at the free form and the untreated control. The induction of apoptosis associated with PS-translocation was determined to be the main mechanism of their cytotoxic effects. Moreover, the safety profiles of the nanoformulations were established through hemolysis assay and the analysis of the viability of human colorectal fibroblasts. It was indicated that all tested nanoparticles met the compatibility requirements at the in vitro level. It should be emphasized that in many cases, there was a significant improvement in the compatibility of hybrids with the FA motif compared to non-functionalized hybrids with the addition of 5-FU. These findings suggest that the presence of FA might modulate the toxicity of chemotherapeutic agents.
Since the anatomical location and appearance of the parathyroid gland (PTG) vary, detection of the PTG and preserving the blood supply are among the difficulties encountered during a thyroidectomy procedure. Resection of the PTG by mistake or interruption of the blood supply may lead to transient or permanent hypoparathyroidism, which would require short-term or lifelong calcium and/or vitamin D supplement. We are planning to train a deep convolutional neural network based on a larger sample of endoscopic images to develop a model to assist surgeons in detection of PTG during endoscopic thyroidectomy. Although several researchers indicated that indocyanine green fluorescence angiography could be used to assess the perfusion of the PTG intraoperatively, it may cause allergic reaction and need repetitive injection. Therefore, we would like to train a DCNN to predict blood perfusion based on endoscopic images comparing to indocyanine green fluorescence angiography as reference standard, and assess the performance of DCNN in predicting postoperative hypoparathyroidism. This research may lead to the development of endoscopic modules in PTG detection and PTG perfusion prediction to reduce postoperative hypoparathyroidism.
Baseline evaluation will consist of measurement of best-corrected ETDRS visual acuity, complete eye exam, including IOP measurement, color photos and intravenous fluorescein angiography, spectral domain OCT and vitals. Patients meeting eligibility criteria will be treated with an intravitreal injection of 2.0 mg aflibercept under usual aseptic precautions. Follow up visits will be on Day 7, 30, 60, 90, 120, 150 and 180. At each follow-up visit, best-corrected ETDRS visual acuity, IOP measurement and central foveal thickness (CFT) by SDOCT will be obtained. Color photos and IVFA will be performed at month 3 and 6 visits.

Retreatment shall be performed no sooner than two months after previous injection for one or more the following criteria 1. CFT \>310 microns 2. Intraretinal or subretinal fluid on SDOCT 3. Increase in CFT by 50 or more microns from the lowest value observed after intravitreal aflibercept injection 4. Decrease in vision by 5 or more letters frpm the previous visit associated with OCT evidence of macular edema. 5. Appearance of new hemorrhage on color photographs.

Final follow-up will be at six months. Data collected will include, change in ETDRS visual acuity from the baseline, change in CFT, number of injections, number of eyes completely dry by SDOCT, and number of eyes with a thrombosed RAM by IVFA.
<P>PROBLEM TO BE SOLVED: To provide a spray composition which can be sprayed on the scalp of a thin hair portion to give an appearance having the black and thick hairs to the scalp.  <P>SOLUTION: This spray composition is characterized by comprising (a) 8 wt. % of fine powder having a particle diameter of about 13 μm and comprising [bamboo charcoal] produced from bamboo as a raw material, (b) 25 to 35 wt. % of ethanol as a solvent, and (c) 6 to 24 wt. % of dimethyl ether and 36 to 64 wt. % of liquidized petroleum gas as propellants. The fine powder having a particle diameter of about 13 μm and comprising bamboo charcoal is charged into a spray container together with the solvent and the propellants and then sprayed from the spray container. Thereby, the fine powder having a particle diameter of about 13 μm and comprising the bamboo charcoal can be attached to the scalp and the thin hair, and can give an appearance having black and thick hairs to the scalp. When the fine powder having a particle diameter of about 13 μm and comprising the bamboo charcoal is adhered to the scalp and the thin hair, the hair and the scalp can be cared by the antibacterial and deodorizing properties of the bamboo charcoal, itself.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Scoliosis is a skeletal issue causing asymmetries, leading to functional disruptions. Common symptoms include uneven eye tilt, drop asloped shoulder, and muscle imbalances. These changes can affect the patient's physical appearance and psychological state. Current treatments have shown suboptimal results due to the lack of accepted scientific theories for idiopathic scoliosis. Therefore, a new therapeutic approach is needed to provide novel insights and improve treatment outcomes. This underscores the need for a more comprehensive approach to scoliosis treatment.