anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients receive bortezomib 1.6 mg/m\^2 IV on days 1, 8, 15, and 22 once daily for 4 weeks. There will be a 4 week rest period. One cycle is a total of 8 weeks. A total of 10 cycles of bortezomib will be given in the absence of disease progression or unacceptable toxicity.
Death from overdose has occurred in patients ingesting trazodone hydrochloride and other CNS depressant drugs concurrently (alcohol; alcohol and chloral hydrate and diazepam; amobarbital; chlordiazepoxide; or meprobamate).

The most severe reactions reported to have occurred with overdose of trazodone hydrochloride alone have been priapism, respiratory arrest, seizures, and ECG changes, including QT prolongation. The reactions reported most frequently have been drowsiness and vomiting. Overdosage may cause an increase in incidence or severity of any of the reported adverse reactions.

There is no specific antidote for trazodone hydrochloride overdose. In managing overdosage, consider the possibility of multiple drug involvement. For current information on the management of poisoning or overdose, contact a poison control center (1-800-222-1222 or www.poison.org).
Esophageal cancer (EC) is among the most aggressive malignancies, ranking as the seventh most prevalent malignant tumor worldwide. Lymph node metastasis (LNM) indicates localized spread of cancer and often correlates with a poorer prognosis, emphasizing the necessity for neoadjuvant systemic therapy before surgery. However, accurate identification of LNM in EC presents challenges due to the lack of satisfactory diagnostic techniques. Imaging techniques, including ultrasound and computerized tomography scans, have low sensitivity and accuracy in assessing LNM. Additionally, the existing serological detection lacks precise biomarkers. The intricate and not fully understood molecular processes involved in LNM of EC contribute to current detective limitations. Recent research has shown potential in using various molecules, circulating tumor cells (CTCs), and changes in the microbiota to identify LNM in individuals with EC. Through summarizing potential biomarkers associated with LNM in EC and organizing the underlying mechanisms involved, this review aims to provide insights that facilitate biomarker development, enhance our understanding of the underlying mechanisms, and ultimately address the diagnostic challenges of LNM in clinical practice.
The study's focus on a brief mindfulness-based self-compassion intervention stands out as a resource-efficient and practical approach to addressing aggression in adolescents. This concise intervention's potential effectiveness offers the promise of a more accessible and cost-effective approach to addressing adolescent aggression, which is critical in our resource-constrained world. The study determined that the brief intervention is efficacious, enabling its adaptation and implementation in educational institutions, juvenile justice programs, and community organizations that work with belligerent adolescents. Due to its versatility, the conclusions of the study can be directly applied to real-world issues. The salient feature of this method is in its explicit targeting of adolescent aggression. By prioritizing self-compassion and mindfulness, this program aids in the regulation of emotions and reduces aggression among young individuals. Effective interventions have the potential to improve the psychological well-being, emotional control, and interpersonal connections of adolescents who display aggressive behavior. This study has the potential to make mindfulness-based self-compassion practices more easily available to a greater number of adolescents. This might lead to the development of practical and cost-effective solutions that promote emotional well-being and decrease aggressiveness. These strategies would have long-lasting advantages.
Sleep is important for the growth and development of infants. There are different states that make up sleep wake cycles including quiet sleep, active sleep, and transitional sleep. The amount of time that infants spend in quiet sleep increases as they mature. There are different tools that can be used to measure sleep state including EEG, behavior, and vital signs. Recent research has looked at ways to improve sleep in infants admitted to the NICU including music and maternal voice. The investigators are interested in studying maternal scent. Maternal scent has been shown to improve infant feeding and to reduce infant crying during painful procedures. Therefore, the investigators are interested in studying how maternal scent might affect sleep wake state in infants admitted to the NICU. The investigators will observe infant behavior and use EEG and vital signs to assess sleep state in infant after they are exposed to maternal scent.
Patients receive treatment summaries and plan report that captures patient data through the use of an "intake checklist" completed during the initial consultation with the breast oncology team and used to guide referrals to existing services and programmed with generic information related to disease and treatment management plan. Additional elements, such as psycho-social services, exercise, and/or nutrition, identified by the patient self-report, will be incorporated. Patients also complete 3 questionnaires at each clinic visit.
INTRODUCTION: An area of emerging interest in chronic pain populations concerns fear of pain and associated fear of movement (kinesiophobia)-a cognitive appraisal pattern that is well-validated in non-headache chronic pain. However, there is limited research on whether this construct can be measured in a similar manner in headache populations.
METHODS: The current project details a confirmatory factor analysis of the 12-Item Tampa Scale of Kinesiophobia (TSK-12) using a clinical data set from 210 adults with diverse headache diagnoses presenting for care at a multidisciplinary pain clinic. One item (concerning an "accident" that initiated the pain condition) was excluded from analysis.
RESULTS: Results of the confirmatory factor analysis for the remaining 12 items indicated adequate model fit for the previously established 2-factor structure (activity avoidance and bodily harm/somatic focus subscales). In line with previous literature, total TSK-12 scores showed moderate correlations with pain severity, pain-related interference, positive and negative affect, depressive and anxious symptoms, and pain catastrophizing.
DISCUSSION: The current study is the first to examine the factor structure of the TSK-12 in an adult headache population. The results support the relevance of pain-related fear to the functional and psychosocial status of adults with chronic headache, although model fit of the TSK-12 could be characterized as adequate rather than optimal. Limitations of the study include heterogeneity in headache diagnosis and rates of comorbid non-headache chronic pain in the sample. Future studies should replicate these findings in more homogenous headache groups (eg, chronic migraine) and examine associations with behavioral indices and treatment response.
The present invention relates generally to a method for the prophylaxis and treatment of infection by microorganisms in biological environments from where the microorganisms acquire iron, heme or porphyrin, generally but not exclusively for growth. Particular biological environments contemplated by the present invention include but are not limited to vascular regions and cavities as well as mucosal membranes in animals including mammals, reptiles, amphibians and fish and in avian species as well as hooves of livestock animals. The method of the present invention involves interrupting, reducing or otherwise antagonizing the interaction between a microbial-derived polypeptide, such as but not limited to a polypeptide having cysteine proteinase activity, and a porphyrin-containing molecule in such as heme. The present invention further provides agents useful in the prophylaxis and treatment of microbial infection of biological environments such as vascular regions and cavities including mucosal membranes as well as hooves involving microbial acquisition of iron, heme or porphyrin. Such agents are particularly useful as components in therapeutic compositions. Particularly important microbial infections targeted by the present invention involve infections in the oral cavity, nasopharynx, oropharynx, vagina and urethra in mammals such as humans. Other important microbial infections including infections of hooves in livestock animals such as sheep, cattle and goats.
A pharmaceutical composition for preventing and treating cancer which contains a benzamide derivative is provided to prevent and treat various cancer including colorectal cancer by relating to the growth delay of tumor cell and inhibition of cell proliferation. A pharmaceutical composition for preventing and treating cancer comprises a benzamide derivative of the chemical formula 1 or its pharmaceutically allowable salt. In the chemical formula 1, A is -(CH2)0- or -(NR3)-; B is -(CH2)0- or -(NH)n(NR4)-; n is 0-1; R3 and R4 is hydrogen or alkyl each. The benzamide is denoted by the chemical formulas 2 to 5. The pharmaceutical composition is used for preventing and treating colorectal cancer, breast cancer, liver cancer, prostate cancer, ovarian cancer, and gastric cancer. The pharmaceutical composition is used in a form of oral formulation, parenteral formulation, or percutaneous formulation.
The invention discloses a nano-silver antibacterial moisture-preserving skin refreshing toner. The skin refreshing toner is characterized in that the skin refreshing toner comprises following components by weight: 0.2-10% of a moisture-preserving agent, 0.1-3% of a nutritional agent, 0.0005-0.1% of nano-silver and 0.001-0.1% of an essence, the balance being water. The skin refreshing toner is free from organic preservatives and uses the nano-silver as an anticorrosion antibacterial agent. The nano-silver not only has an anticorrosion function to the product, but also has a function of antisepsis and anti-inflammation and a function of accelerating restoration of damaged skin. In addition, the skin refreshing toner is colorless and transparent, strongly stable, mild, fresh, and nonirritating. The skin refreshing toner has a perfect moisture preserving function, can replenishing skin with water rapidly, and also has functions of weakening skin winkles, enhancing skin elasticity, removing skin toxin, and activating skin. A preparation method has characteristics of simple operation, wide parameter adjustable range, low energy consumption, short period, and the like, and is particularly suitable for pilot plant test amplification and industrialized large-scale production.
The present invention relates to Chinese medicinal soft capsules, particularly to soft capsules for promoting the restoration of consciousness and treating rhinitis and a preparation technology thereof. The soft capsules of the present invention are prepared from medicinal liquid and capsule materials, wherein the medicinal liquid comprises volatile oil and medicinal material extract which is prepared from the following raw materials (parts by weight): 324 parts of siberian cocklebur fruit, 243 parts of ledebouriella root, 405 parts of milkvetch root, 243 parts of dahurian angelica, 243 parts of biond magnolia flower, 243 parts of white atractylodes rhizome and 81 parts of peppermint; the medicinal liquid also comprises a suspending agent and vegetable oil. In each 1000 granules of the soft capsules for promoting the restoration of consciousness and treating rhinitis, the content of the extract is from 135 to 315 g, the content of the volatile oil is from 3 to 20g, the content of the suspending agent is 1 to 5% of that of the medicinal liquid, and the content of the vegetable oil is proper. The capsule materials comprise gelatin, a plasticizing agent and water. Compared with tablets, the soft capsules for promoting the restoration of consciousness and treating rhinitis improve the curative effect and are suitable for clinical treatment of rhinitis of patients witho have weak physical quality and easy infection of common cold. In the present invention, the weight proportioning of the medicinal material extract, the volatile oil and the vegetable oil are preferably selected, the content of the medicinal liquid in the whole capsules is improved, and the content of auxiliary materials is reduced.
A breathable disposable absorbent article which is substantially flat prior to use for wearing adjacent a body discharge area having a longitudinal centreline and a lateral centreline orthogonal thereto and defining longitudinal and lateral directions respectively. The disposable absorbent article comprises a liquid pervious topsheet, a backsheet joined to said topsheet and an absorbent core intermediate the backsheet and the topsheet. The absorbent core comprises means for expanding the article into a tridimensional structure while being worn by a user. The means is activated by body fluids. The absorbent article comprises a backsheet that is water vapour permeable, preferably air permeable. The absorbent article can optionally comprise an odour-control material comprising one or more odour-control agents in order to minimize odour caused by body fluids.
BACKGROUND: De novo diffuse coronary artery disease (CAD) is a challenging scenario in interventional cardiology with limited treatment option, beside stent implantation. In this context, a hybrid approach, combining the use of drug-eluting stent (DES) and drug-coated balloon (DCB) to treat different segments of the same lesion (e.g. long lesion and/or true bifurcation), might be an interesting and alternative strategy to limit the metal amount. The aim of this study was to evaluate the safety and efficacy of a hybrid approach in addressing percutaneous treatment of de novo diffuse CAD.
METHODS: This was a prospective, multicenter study including patients affected by de novo diffuse CAD treated with a hybrid approach from April 2019 to December 2020. Angiographic and clinical data were collected. The primary endpoint was the one-year device-oriented composite endpoint (DOCE, cardiac death, target vessel myocardial infarction and ischemia-driven target lesion revascularization [ID-TLR]). Periprocedural myocardial infarctions and periprocedural success were included among secondary endpoints.
RESULTS: One hundred six patients were included, mean age was 68.2±10.2 years and 78.3% were male. De novo diffuse CAD consisted of 52.8% long lesions and 47.2% true bifurcation lesions. Significant increase in the final minimal lumen diameters and significant decrease in the final diameter stenosis were observed when compared to the baseline values in both DES- and DCB-target segments. Procedural success was 96.2%. DOCE at one-year was 3.7%, with all the adverse events characterized by ID-TLR.
CONCLUSIONS: Combination of DES and DCB could be a safe and effective treatment option for the treatment of de novo diffuse CAD (NCT03939468).
For Aim 3, individuals employed at harm reduction programs in NYC will be enrolled for a one-time qualitative interview. Qualitative interviews will explore organizational (i.e., readiness, culture, and priorities), individual (i.e., attitudes and norms), and intervention (i.e., complexity and advantage) characteristics related to the integration of mental health and harm reduction services. Findings will inform efforts to scale ancillary mental health services high-risk PSU population.
A system and a method for monitoring a brain CT scan image using ASPECTS score. The method includes receiving the brain CT scan image of a patient. Further, a basal ganglia region and a corona radiata level are identified in a plurality of slices in the brain CT scan image. Furthermore, a plurality of anatomical regions, a plurality of infarcts and a plurality of black regions are segmented using deep learning. Subsequently, an overlapping region across the plurality of slices is determined based on the plurality of anatomical regions, the plurality of infarcts, and the plurality of black regions. The overlapping region and a predefined threshold are used to compute an ASPECTS score. The ASPECTS score is further used to recommend a course of action to the patient.
INTRODUCTION: Limited research exists on substance-related acute toxicity deaths (ATDs) in older adults (≥60 years) in Canada. This study aims to examine and describe the sociodemographic characteristics, health histories and circumstances of death for accidental ATDs among older adults.
METHODS: Following a retrospective descriptive analysis of all coroner and medical examiner files on accidental substance-related ATDs in older adults in Canada from 2016 to 2017, proportions and mortality rates for coroner and medical examiner data were compared with general population data on older adults from the 2016 Census. Chisquare tests were conducted for categorical variables where possible.
RESULTS: From 2016 to 2017, there were 705 documented accidental ATDs in older adults. Multiple substances contributed to 61% of these deaths. Fentanyl, cocaine and ethanol (alcohol) were the most common substances contributing to death. Heart disease (33%), chronic pain (27%) and depression (26%) were commonly documented. Approximately 84% of older adults had contact with health care services in the year preceding their death. Only 14% were confirmed as having their deaths witnessed.
CONCLUSIONS: Findings provide insight into the demographic, contextual and medical history factors that may influence substance-related ATDs in older adults and suggest key areas for prevention.
Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance, treatment with this drug would be inappropriate and possibly harmful [see Error! Hyperlink reference not valid. (Error! Hyperlink reference not valid.)].

Rarely development of Ogilvie’s syndrome (colonic pseudo-obstruction) has been reported. Ogilvie’s syndrome is a clinical disorder with signs, symptoms, and radiographic appearance of an acute large bowel obstruction but with no evidence of distal colonic obstruction
BACKGROUND: This study analyzed the extent to which irregularities in genetic diversity separate psychiatric patients from healthy controls.
METHODS: Genetic diversity was quantified through multidimensional "gene vectors" assembled from 4 to 8 polymorphic SNPs located within each of 100 candidate genes. The number of different genotypic patterns observed per gene was called the gene's "diversity index".
RESULTS: The diversity indices were found to be only weakly correlated with their constituent number of SNPs (20.5 % explained variance), thus suggesting that genetic diversity is an intrinsic gene property that has evolved over the course of evolution. Significant deviations from "normal" diversity values were found for (1) major depression; (2) Alzheimer's disease; and (3) schizoaffective disorders. Almost one third of the genes were correlated with each other, with correlations ranging from 0.0303 to 0.7245. The central finding of this study was the discovery of "singular genes" characterized by distinctive genotypic patterns that appeared exclusively in patients but not in healthy controls. Neural Nets yielded nonlinear classifiers that correctly identified up to 90 % of patients. Overlaps between diagnostic subgroups on the genotype level suggested that (1) diagnoses-crossing vulnerabilities are likely involved in the pathogenesis of major psychiatric disorders; (2) clinically defined diagnoses may not constitute etiological entities.
CONCLUSION: Detailed analyses of the variation of genotypic patterns in genes along with the correlation between genes lead to nonlinear classifiers that enable very robust separation between psychiatric patients and healthy controls on the genotype level.
Intervention participants receive the PAW toolkit plus 3 x optional occupational therapy calls (approximately 30 minutes each) involving orientation to the PAW Toolkit and individually tailored advice and behavioural strategies for managing pain at work. This digital web-based toolkit is designed to support people with chronic pain in self-managing their condition at work. PAW offers evidence-based advice about chronic or persistent pain, disability rights, work capacity, pain self-management strategies and signposting to support.
1513948 Sulphamoyl- and sulphonyl-containing thiazolidines HOECHST AG 24 July 1975 [27 July 1974] 30973/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R1 stands for alkyl or alkenyl radicals of 1 to 4 carbon atoms, cycloalkyl radicals of 3 to 6 carbon atoms, or dialkylamino groups having a total of 7 carbon atoms, which may from together with the nitrogen-atom of the amino group a saturated heterocyclic ring. R2 stands for an alkyl or alkenyl or alkynyl radical of 1 to 8 carbon atoms, optionally substituted by alkoxy groups of 1 to 4 carbon atoms, cycloalkyl radicals of 3 to 8 carbon atoms; phenylalkyl radicals of 1 or 2 carbon atoms in the alkyl moiety, optionally substituted in the phenyl ring by halogen, alkyl, alkoxy or alkylene dioxy, further for alkyl groups of 1 or 2 carbon atoms which are substituted by cycloalkyl radicals of 3 to 6 carbon atoms or 5- or 6- membered saturated or unsaturated heterocyclic radicals containing oxygen, nitrogen or sulfur, or for dialkylamino groups having a total of 7 carbon atoms, which may form together with the nitrogen atom of the amino group a saturated heterocyclic ring, and in which R1 and R2 together, may also stand for an alkylene group of 2 to 4 carbon atoms, R3 stands for hydrogen or alkyl of 1 or 2 carbon atoms, R4 and R5 are identical or different and each stands for hydrogen, alkyl or alkenyl radicals of I to 6 carbon atoms, optionally substituted by alkoxy of 1 to 4 carbon atoms, cycloalkyl or cycloalkylalkyl of 3 to 9 carbon atoms, phenyl, phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety, the phenyl ring may, optionally, be substituted by halogen, alkyl, alkoxy or alkylenedioxy, further for alkyl groups of 1 or 2 carbon atoms which are substituted by 5- or 6-membered unsaturated heterocyclic radicals containing oxygen, nitrogen or sulfur, R4 and R5 may also form together with the nitrogenatom a saturated, optionally methyl-substituted 5- or 6-membered heterocyclic ring, in which optionally a CH 2 -group may be replaced by oxygen, and Y stands for hydrogen, halogen, methyl or trifluoromethyl. They are made (a) by reacting compounds (II) (Z is a radical of an activated ester) with thioureas (III) of formula (b) by halogenating (IV) and reacting compounds (V) obtained with (III) and thereafter reacting (VI) obtained with R4R5NH, (c) by reacting compounds (VIII) with Hal . C(:NR1). NHR2 or with (e) by oxidizing compounds (XI) and (f) by interacting (XII) and (XIII) and hydrolysing the products obtained (R4 and R5 are not H, Y is not Br or I and M is Li or MgBr); compounds (I) where R4 and/or R5 are H can be alkylated to give other compounds (I). Pharmaceutical preparations having saluretic and diuretic actions contain (I) as active ingredient. Administration is parenterally.