anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the technical field of traditional Chinese medicine composition preparation, and relates to a foot bath composition capable of relieving sports fatigue. The composition is composed of the following raw materials in parts by weight: 10 to 30 parts of scorzonera austriaca, 10 to 30 parts of plantain, 10 to 30 parts of cirsium setosum, 10 to 30 parts of sonchus oleraceus, 10 to 30 parts of polygonum aviculare, 10 to 20 parts of reed root, 5 to 10 parts of willow bark, and 2 to 5 parts of turpentine. The preparation method comprises the following steps: washing fresh natural plant raw materials, naturally drying raw materials, cutting raw materials into blocks, drying the blocks at a temperature of 60 to 70 DEG C, cutting all raw materials into particles with a particle size of 2 to 5 millimeters to obtain raw material powder, weighing raw material powder according to the weight ratio mentioned above, adding turpentine, mixing, evenly stirring to obtain a composition; mixing the composition with white vinegar and seawater according to a weight ratio of 1:(2-3):(10-20), boiling the mixture for 30 to 60 minutes at a temperature of 80 to 100 DEG C, naturally cooling, filtering the solution to remove solids so as to obtain the liquid foot bath composition, hermetically sealing the composition, and saving for later use. The formula is scientific and reasonable. The raw materials are easily available. The composition is user-friendly. The effect is prominent. The manufacturing technology is simple. The composition can well relieve the fatigue and treat beriberi.
Adipose tissue group 2 innate lymphoid cells (ILC2s) help maintain metabolic homeostasis by sustaining type 2 immunity and promoting adipose beiging. Although impairment of the ILC2 compartment contributes to obesity-associated insulin resistance, the underlying mechanisms have not been elucidated. Here, we found that ILC2s in obese mice and humans exhibited impaired liver kinase B1 (LKB1) activation. Genetic ablation of LKB1 disrupted ILC2 mitochondrial metabolism and suppressed ILC2 responses, resulting in exacerbated insulin resistance. Mechanistically, LKB1 deficiency induced aberrant PD-1 expression through activation of NFAT, which in turn enhanced mitophagy by suppressing Bcl-xL expression. Blockade of PD-1 restored the normal functions of ILC2s and reversed obesity-induced insulin resistance in mice. Collectively, these data present the LKB1-PD-1 axis as a promising therapeutic target for the treatment of metabolic disease.
The learned resourcefulness program includes: 1) Solving problem strategy, 2) Organizing daily actions, 3) Using self-regulation, 4) Reframing positive situations, 5) Changing negative self-thinking, 6) Exploring new thinking and skills. It is conducted one time per week.
Sirtuin3 (Sirt3) is a nicotinamide adenine dinucleotide enzyme that contributes to aging, cancer, and neurodegenerative diseases. Recent studies have reported that Sirt3 exerts anti-inflammatory effects in several neuropathophysiological disorders. As epilepsy is a common neurological disease, in the present study, we investigated the role of Sirt3 in astrocyte activation and inflammatory processes after epileptic seizures. We found the elevated expression of Sirt3 within reactive astrocytes as well as in the surrounding cells in the hippocampus of patients with temporal lobe epilepsy and a mouse model of pilocarpine-induced status epilepticus (SE). The upregulation of Sirt3 by treatment with adjudin, a potential Sirt3 activator, alleviated SE-induced astrocyte activation; whereas, Sirt3 deficiency exacerbated astrocyte activation in the hippocampus after SE. In addition, our results showed that Sirt3 upregulation attenuated the activation of Notch1 signaling, nuclear factor kappa B (NF-κB) activity, and the production of interleukin-1β (IL1β) in the hippocampus after SE. By contrast, Sirt3 deficiency enhanced the activity of Notch1/NF-κB signaling and the production of IL1β. These findings suggest that Sirt3 regulates astrocyte activation by affecting the Notch1/NF-κB signaling pathway, which contributes to the inflammatory response after SE. Therefore, therapies targeting Sirt3 may be a worthy direction for limiting inflammatory responses following epileptic brain injury.
The technique known as myofascial release, also referred to as cross-hand release, will be applied to 7 regions. Among these regions are the lateral abdominal wall (right and left), the lower abdomen with the opposite side medial thigh (right and left crossed), the thoracolumbar fascia (bilateral), and the lumbosacral region. In the cross-hand technique, hands will be gently placed on the specified regions and directions. The release of the barriers of the tissue under the hands will be ensured, and the technique will be applied until a wave or oscillation is felt. A myofascial release technique with an optimal duration of 5 minutes will be applied to each region. The total treatment time will be 35 minutes.
The invention relates to a process for purifying human von Willebrand factor from a cryoprecipitated plasma fraction, which comprises a combination of three chromatographic separation steps. The first chromatographic separation step comprises contacting a cryoprecipitated fraction with a large-pore vinyl polymer resin having DEAE group. The effluent from this separation step is again contacted with a large pore vinyl polymer resin having DEAE groups in the second chromatographic step. In the third chromatographic separation step, the effluent from the second step is subjected to affinity chromatography by contacting with gelatin-Sepharose. The concentrate obtained has very high specific activity and a high percentage of high molecular weight multimers. The concentrate is intended, in particular, for therapeutic use.
Although carbidopa-levodopa is the most frequently used of carbidopa and levodopa administration, there may be an occasional patient who requires individually titrated doses of these two drugs. In these patients, carbidopa should be initiated at a dosage of 25 mg three or four times a day. The two drugs should be given at the same time, starting with no more than one-fifth (20%) to one-fourth (25%) of the previous or recommended daily dosage of levodopa when given without carbidopa. In patients already receiving levodopa therapy, at least twelve hours should elapse between the last dose of levodopa and initiation of therapy with carbidopa and levodopa. A convenient way to initiate therapy in these patients is in the morning following a night when the patient has not taken levodopa for at least twelve hours. 

  


Health care providers who prescribe separate doses of carbidopa and levodopa should be thoroughly familiar with the directions for use of each drug.
Patients randomized to the hypertonic saline group will be administered one nebulized treatment of 3% hypertonic saline. They will also receive what is considered standard of care, which includes suctioning and supportive care as needed.
A Chinese medicinal decoction containing hydrogen and its preparation method are provided. The method comprises the steps of filtering a liquid medicine decocted from mature Chinese herbal medicines in a formula by a full-automatic Chinese herbal medicine decocting machine (patent No. ZL 202120373922.2), degassing in vacuum, homogenizing, sterilizing at ultrahigh temperature, degassing in vacuum, cooling, adding hydrogen, temporarily storing in an air-isolating sterile tank (patent No. ZL 201920845235.9), regulating and controlling the liquid medicine to a sterile filling machine, and filling the isolated air into an aluminum foil bag or an aluminum pop can. The product treated by the above process has reduced smell and taste of Chinese herbal medicines, enhanced medicinal properties, and increased effects of "hydrogen medicine". 1, selective oxidation resistance. 2, anti-inflammation. 3, resisting apoptosis. And 4, clearing hydroxyl free radicals in human bodies. 5 scavenging of nitrite anions in the human body. 6, the health-care food can improve the immunity, is nontoxic and harmless to a human body, has no residue, and has a protection function on cerebral cell ischemia and reperfusion. The shelf life of the liquid medicine is greatly prolonged because the liquid medicine does not contain air oxygen.
The Ang-(1-7)/MasR axis is critically involved in treating several diseases; For example, Ang-(1-7) improves inflammatory response and neurological function after traumatic brain injury and inhibits post-inflammatory hypothermia. However, its function in traumatic brain injury (TBI) combined with seawater immersion hypothermia remains unclear. Here, we used a mice model of hypothermic TBI and a BV2 cell model of hypothermic inflammation to investigate whether the Ang-(1-7)/MasR axis is involved in ameliorating hypothermic TBI. Quantitative reverse transcription PCR, western blotting assay, and immunofluorescence assay were performed to confirm microglia polarization and cytokine regulation. Hematoxylin-eosin staining, Nissl staining, and immunohistochemical assay were conducted to assess the extent of hypothermic TBI-induced damage and the ameliorative effect of Ang-(1-7) in mice. An open field experiment and neurological function scoring with two approaches were used to assess the degree of recovery and prognosis in mice. After hypothermic TBI establishment in BV2 cells, the Ang-(1-7)/MasR axis induced phenotypic transformation of microglia from M1 to M2, inhibited IL-6 and IL-1β release, and upregulated IL-4 and IL-10 levels. After hypothermic TBI development in mice, intraperitoneally administered Ang-(1-7) attenuated histological damage and promoted neurological recovery. These findings suggest that hypothermia exacerbates TBI-induced damage and that the Ang-(1-7)/MasR axis can ameliorate hypothermic TBI and directly affect prognosis.
In this randomized cluster randomized control trial design, the no intervention arm refers to the 12 study sites that are randomly assigned not to receive the clinician training intervention. Instead, these study sites will receive the standard of care, which is no standardized patient actor training, for health care workers who deliver PrEP to adolescent girls and young women to prevent HIV.
Soft-tissue balancing is an important factor in primary total knee arthroplasty (TKA), with 30 to 50% of TKA revisions attributed to technical operative factors including soft-tissue balancing. Robotic-assisted TKA (RATKA) offers opportunities for improved soft-tissue balancing methods. This study aimed to evaluate the repeatability and reproducibility of ligamentous laxity assessments during RATKA using a digital tensioner.Three experienced RATKA surgeons assessed preresection and trialing phases of 12 human cadaveric knees with varying degrees of arthritis. Ligamentous laxity was assessed with manual varus and valgus stresses in extension and flexion, with a digital tensioner providing feedback on the change of laxity displacement. Intraclass correlation coefficient (ICC) analyses were used to determine the repeatability within a single surgeon and reproducibility between the three surgeons.The results showed excellent repeatability and reproducibility in ligamentous laxity assessment during RATKA. Surgeons had excellent repeatability for preresection and trialing assessments, with median ICC values representing excellent reproducibility between surgeons. Surgeons were repeatable within 1 or 1.5 mm for preresection and trialing assessments. On average, the variation within a surgeon was 0.33 ± 0.26 mm during preresection and 0.29 ± 0.28 mm during trialing. When comparing surgeons to each other, they were reproducible within an average of 0.69 ± 0.33 mm for preresection and 0.65 ± 0.31 mm for trialing.This study demonstrated the reliability of robotic-assisted soft-tissue balancing techniques, providing control over ligamentous laxity assessments, and potentially leading to better patient outcomes. The digital tensioner used in this study provided excellent repeatability and reproducibility in ligamentous laxity assessment during RATKA, highlighting the potential benefits of incorporating robotics in TKA procedures.
A scan recommendation method is disclosed, wherein evaluation data comprising classification data (CIA, CMA) are received, wherein the classification data (CIA, CMA)) classify anomalies (IA, MA) detected in input data (ID, IM, IHRI, UII) concerning the medical condition of a patient. Based on the evaluation data an automatic determination of a next recommended MR protocol (NRP) to be executed in accordance with an MR scan of the patient is performed. Further, a personal scan preparation method is disclosed. Furthermore, a medical imaging method is described. Also a scan workflow performing method is described. For carrying out the above-mentioned methods, a scan recommendation system (45), a personal scan preparation system (40), a medical imaging system (50) and a scan workflow performing system (60) are also described.
Due to molecular forces, biomacromolecules assemble into liquid condensates or solid aggregates, and their corresponding formation and dissolution processes are controlled. Protein homeostasis is disrupted by increasing age or environmental stress, leading to irreversible protein aggregation. Hypoxic pressure is an important factor in this process, and uncontrolled protein aggregation has been widely observed in hypoxia‑related conditions such as neurodegenerative disease, cardiovascular disease, hypoxic brain injury and cancer. Biomolecular condensates are also high‑order complexes assembled from macromolecules. Although they exist in different phase from protein aggregates, they are in dynamic balance under certain conditions, and their activation or assembly are considered as important regulatory processes in cell survival with hypoxic pressure. Therefore, a better understanding of the relationship between hypoxic stress, protein aggregation and biomolecular condensation will bring marked benefits in the clinical treatment of various diseases. The aim of the present review was to summarize the underlying mechanisms of aggregate assembly and dissolution induced by hypoxic conditions, and address recent breakthroughs in understanding the role of aggregates in hypoxic‑related diseases, given the hypotheses that hypoxia induces macromolecular assemblage changes from a liquid to a solid phase, and that adenosine triphosphate depletion and ATP‑driven inactivation of multiple protein chaperones play important roles among the process. Moreover, it is anticipated that an improved understanding of the adaptation in hypoxic environments could extend the overall survival of patients and provide new strategies for hypoxic‑related diseases.
A dyeing composition for hair with improved dyeing and conditioning properties of hair, based on at least one oxidizing agent and at least one hair dye and comprising a polyhydroxy carboxylic acid as a chelating agent. The compositions of the present invention may be aqueous compositions. The preferred polyhydroxy carboxylic acid is gluconic acid and its salts. The oxidizing agent may be hydrogen peroxide. The hair dye may be an oxidation dye precursor and/or a direct dye. A kit for dyeing hair comprises one composition comprising a hair dye and a polyhydroxy carboxylic acid and another composition comprising an oxidizing agent. A process for dyeing hair comprises mixing a composition comprising a hair dye and a polyhydroxy carboxylic acid with an aqueous oxidizing composition, applying to hair and rinsing after 1 to 45 minutes.
PURPOSE:The titled composition, containing a powdered zedoary or an extract thereof with an aqueous solvent as an active constituent, and capable of exhibiting improved effect on prevention and treatment of periodontitis, e.g. pyrrhoea alveolaris or gingivitis, etc. CONSTITUTION:A dentifrice composition containing a powdered zedoary (Curcuma zedoaria Roscoe) or an extract thereof with an aqueous solvent, e.g. ethanol, as an active constituent. Periodontitis is generally started in the inflammation in the periodontal tissue to cause the redness, swelling and bleeding of the gum, and chronic progress thereof forms the so-called periodontal pocket between teeth. Thus, the deflection of teeth and bad breath are caused to proceed into pyrrhoea alveolaris. The continuous use of the powdery zedoary by the oral smearing has an effect on the anti-inflammation of the periodontal tissue, and the periodontal pocket is reduced to tighten the gum and stop the bleeding. The amount of the zedoary to be incorporated is preferably 0.1wt% or more based on the dentifrice composition.
The investigators will enroll 150 sedentary Pacific Islander (PcI) adults. The investigators will first use an evidence-based physical activity (PA) program tool on all participants to stimulate their PA levels, and then study how contextual and psychosocial factors influence PA initiation and maintenance. The investigators will assess participants for 5 separate weeks during a 20-month span using real-time, field-based, state-of-the-art methodologies consisting of MotionSense (a well-validated on-body mobile sensor system), ecological momentary assessment (EMA), and the Global Positioning System (GPS).
Breast cancer is the most widespread type of cancer among women in the USA, and the second leading cause of death. The National Cancer Institute estimates that in 2013, in the USA, 226,870 women will be diagnosed with breast cancer and 39,510 women will die of breast cancer, most of them of progressive metastatic disease. Early detection and treatment of the disease, when the tumor is still localized and at a high curability state, is the outmost important determinant of disease-free survival of breast cancer patients. Survival rate of women first diagnosed with pure early-stage noninvasive tumor (ductal carcinoma in situ- DCIS) is nearly 98%, which drops to 48% in patients with advanced disease.Yet, early detection of breast cancer is relatively poor. This is best exemplify by the astonishing percentage of benign biopsies; 80% of 1.7 million biopsies in the USA, at a cost of $3 billion; whereas, only small fraction (\~20%) of newly diagnosed women are found to have pure DCIS.

Our preclinical studies suggest the capacity of the positron emission tomography (PET) imaging agent 18F-fluorobenzyl triphenyl phosphonium (FBnTP) to detects early-stage small breast tumors (e.g., DCIS), and differentiates benign from malignant masses with better accuracy than that obtained by existing breast imaging tools. Accordingly, the present protocol is designed to extend the preclinical findings into clinical studies in breast cancer women, and to assess the effectiveness of 18F-FBnTP in detecting breast malignant lesions, in comparison with magnetic resonance imaging and fluorodeoxyglucose PET imaging.
The group of inventions relates to molecular biology, biotechnology and medicine and is intended for the prophylaxis and treatment of rotavirus infection. Proposed is a vaccine against rotavirus infection which is based on a fusion protein (SEQ ID NO: 1, SEQ ID NO: 2), consisting of immunogenic epitopes of the VP6 and VP8 proteins linked by a flexible bridge (variants). Also proposed is a vaccine against rotavirus infection which is based on a fusion protein (SEQ ID NO: 3 - SEQ ID NO: 6), consisting of immunogenic epitopes of the VP6 and VP8 proteins and an adjuvant, namely flagellin fragments, linked by flexible bridges (variants). The fusion protein - the active ingredient of vaccines - is produced in prokaryote and eukaryote cells using recombinant DNA technology and various purification methods. The proposed vaccines are shown to be immunologically multivalent against rotavirus groups A, B and C and to have a prophylactic and therapeutic effect. Using these vaccines will make it possible to provide universal protection for humans against rotaviruses.
PROBLEM TO BE SOLVED: To obtain a skin beautifying cosmetic free from skin irritation, having an excellent suppressing effect on the inflammation of skin with ultraviolet rays and suppressing the melanogenesis and effective for quickly fading the deposited pigment of the skin by compounding a specific compound. SOLUTION: The objective cosmetic is produced by compounding at least one kind of substance selected from the compounds of the formula [R1 is H, CH3, C2H5, C3H7 or CH(CH3)2; OR1 is 1 to 3 substituents on each aromatic ring]. The compound of the formula can be produced e.g. by condensing acetone with a benzaldehyde compound and reducing the condensation product with hydrogen in the presence of Raney Ni. Examples of the compound are 1,5-bis[p- hydroxyphenyl]-pentan-3-one and 1,5-bis[2,4-dihydroxyphenyl]-pentan-3-one. The compounding amount of the compound of the formula to a skin beautifying cosmetic is preferably 0.001-5.0 wt.% based on the total amount of the cosmetic.
The trial will be performed as an open-label, non-randomized, single-dose design in eight healthy male or female subjects ages 18 to 45 years inclusive to evaluate the pharmacokinetics and safety profiles of the zoliflodacin formulation. All subjects will be dosed in the morning of Day 1 in a staggered fashion with a minimum of several minutes apart. Each subject will receive a single 4g dose of zoliflodacin (2 x 2 g sachets of zoliflodacin) after at least an 8-h fast, which will continue for at least 4 h after dosing. Consumption of water will be permitted during the fasting period. Subjects will be monitored as inpatients in the Clinical Trial Unit (CTU) up to Day 4 and at the Final Visit (Day 8 ± 2). Study duration is approximately 4 weeks with subject participation duration up to 10 days (from dosing to final visit). The primary objective of this study is to evaluate the plasma PK of zoliflodacin after administration of a single 4-g oral dose under fasting conditions. The secondary objective is to evaluate the safety and tolerability of a single 4-g oral dose of zoliflodacin.
Normally your bones are being rebuilt all the time. First, old bone is removed (resorbed). Then a similar amount of new bone is formed. This balanced process keeps your skeleton healthy and strong.

Osteoporosis is a thinning and weakening of the bones. It is common in women after menopause, and may also occur in men. In osteoporosis, bone is removed faster than it is formed, so overall bone mass is lost and bones become weaker. Therefore, keeping bone mass is important to keep your bones healthy. In both men and women, osteoporosis may also be caused by certain medicines called corticosteroids.

At first, osteoporosis usually has no symptoms, but it can cause fractures (broken bones). Fractures usually cause pain. Fractures of the bones of the spine may not be painful, but over time they can make you shorter. Eventually, your spine can curve and your body can become bent over. Fractures may happen during normal, everyday activity, such as lifting, or from minor injury that would normally not cause bones to break. Fractures most often occur at the hip, spine, or wrist. This can lead to pain, severe disability, or loss of ability to move around (mobility).