anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nicolaides-Baraitser syndrome (NCBRS) is a rare autosomal dominant genetic condition that is characterized by severe intellectual disability, dysmorphic facial features, short stature, sparse hair, and early onset seizures. This diagnosis is established by suggestive clinical findings and the identification of a heterozygous SMARCA2 pathogenic variant by molecular genetic testing. There are not, however, consensus clinical diagnostic criteria for this condition as there are so few documented cases. Here, we present a case of prenatally diagnosed caudal regression with sacral agenesis and congenital vertical talus (rocker bottom feet) that was ultimately found to have a de novo SMARCA2 pathogenic variant. The patient had an amniocentesis with normal karyotype and microarray followed by failed direct rapid whole exome sequencing (WES) due to maternal cell contamination. She elected for termination of the pregnancy based on the clinical prognosis of the ultrasound findings; WES revealed a pathogenic variant after her termination. We believe this is the first case of these findings associated with NCBRS. If any future cases of either finding are found in association with a SMARCA2 genetic variant, caudal regression and rocker bottom feet should be included in the spectrum of physical traits associated with this pathogenic variant.
Adults and children 12 years and over: 

Apply 1 patch to the affected area of intact skin. Gen7T Plus Patch ® should be removed after 12 hours of continuous use and remain off for at least 12 hours. 

  1. Determine area of patch application. If the pain area is smaller than the patch, patches may be cut into smaller sizes with scissors. Safely discard the remaining unused pieces of cut patches where children and pets cannot reach.   

  2. Remove the transparent release liner (clear plastic backing) before application of patches to the skin. Apply immediately after removal from the protective envelope.   

  3. Apply 1 patch to the affected area so that the patch covers most of the painful area. Apply patch only once during each 24-hr period (12 hours on / 12 hours off).   

  4. Remove patch if irritation occurs. 



Children under 12 years of age:Consult a doctor
PURPOSE: An antiobesity agent containing a hot water extract of Piper longum L. is provided to promote lipolysis of subcutaneous adipocytes and to suppress fat accumulation in the subcutaneous adipocytes, thereby preventing or suppressing obesity. CONSTITUTION: An antiobesity agent contains 1-80 wt% of a hot water extract of Piper longum L. as an active ingredient. The extract promotes the decomposition of subcutaneous fat. The obesity is caused by lipid intake. The hot water used for preparing the extract is water of 80-120°C. [Reference numerals] (AA) Degree of fat breakdown (comparing to negative control group); (BB) Hot water 10; (CC) Hot water 50; (DD) Hot water 100; (EE) Alcohol 10; (FF) Alcohol 50; (GG) Alcohol 100
In patients with CLL, GAZYVA caused CD19 B-cell depletion (defined as CD19 B cell counts < 0.07 × 109/L). Initial CD19 B cell recovery was observed in some patients approximately 9 months after the last GAZYVA dose. At 18 months of follow-up, some patients remain B cell depleted.

Although the depletion of B cells in the peripheral blood is a measurable pharmacodynamic effect, it is not directly correlated with the depletion of B-cells in solid organs or in malignant deposits. B cell depletion has not been shown to be directly correlated to clinical response.

Cardiac Electrophysiology

The potential effects of GAZYVA on the QTc interval have not been studied.
The invention discloses an aconite extract-containing medicinal composition, a preparation method and application thereof. The aconite extract-containing medicinal composition combines the viscera cold primordial qi theory of the six primordial qi theory of 'Kazak Medicine Introduction' which is a traditional medical theoretical basis, and has a main function of removing cold diseases. The Kazak traditional medicament aconite is selected to prepare an external preparation by mixing with white sal-ammoniac (NH4Cl) in proportion through water extraction and ethanol extraction. The preparation includes a medicinal extract and all other external preparations suitable for clinical cold inflammation prevention and treatment. The medicinal compositions has good effect of external auxiliary treatment on bone tuberculosis, scrofula, thyroiditis, rhinitis, bronchial asthma, lumbar disc hernia, rheumatoid arthritis, femoral head necrosis, hyperplasia of mammary glands, hysteromyoma, benign prostatic hyperplasia, osteocarcinoma, psoriasis and the like particularly, has the function of relieving pains and inflammation and the like. The medicinal composition has the advantages of reasonable formula, accurate curative effect, quick response, no irritation and other toxic or side effects, and convenience for preparation.
Breast cancer (BC) represents the most prevalent cancer in women at any age after puberty. From a pathogenetic prospective, despite a wide array of risk factors being identified thus far, poor metabolic health is emerging as a putative risk factor for BC. In particular, type 2 diabetes mellitus (T2DM) provides a perfect example bridging the gap between poor metabolic health and BC risk. Indeed, T2DM is preceded by a status of hyperinsulinemia and is characterised by hyperglycaemia, with both factors representing potential contributors to BC onset and progression. Additionally, the aberrant secretome of the dysfunctional, hypertrophic adipocytes, typical of obesity, characterised by pro-inflammatory mediators, is a shared pathogenetic factor between T2DM and BC. In this review, we provide an overview on the effects of hyperglycaemia and hyperinsulinemia, hallmarks of type 2 diabetes mellitus, on breast cancer risk, progression, treatment and prognosis. Furthermore, we dissect the role of the adipose-tissue-secreted adipokines as additional players in the pathogenesis of BC. Finally, we focus on microalgae as a novel superfood and a source of nutraceuticals able to mitigate BC risk by improving metabolic health and targeting cellular pathways, which are disrupted in the context of T2DM and obesity.
To stimulate the left DLPFC, the anode electrode will be placed over F3 and the cathode will be placed over the right supraorbital region (Fp2). Each stimulation will be applied for 20 min at 2mA intensity. Stimulation will be continued with the performance of three cognitive training exercises specifically designed to improving working memory, inhibitory control and cognitive flexibility.
PURPOSE:To prepare an oil-in-water emulsion composition having excellent storage stability, by reacting and emulsifying a mixture of higher fatty acids comprising gehenic acid and a specific fatty acid with a basic compound. CONSTITUTION:An oil-in-water emulsion composition having excellent effect to the skin, is prepared by reacting higher fatty acids with a basic compound, wherein said higher fatty acids are a mixture of behenic acid and a 18-36C fatty acid which is liquid at room temperature, e.g. isostearic acid, oleic acid, ricinoleic acid, etc., and the basic compound is e.g. L-arginine, L-ornithine, L-lysine, KOH, etc. The amount of the higher fatty acid is 0.5-10.0wt% based on the whole composition, and that of the basic compound is 0.1-0.7 part by weight based on 1 part of the higher fatty acid. Addition of sorbitanemonoester, etc. to the composition further improves the stability, and the addition of tocopherol is effective to prevent the time-dependent degradation of the emulsion.
Beginning postoperative day 1, patients wear Fitbit daily with a goal of 2,000 steps until the day of discharge or until 14 days after surgery. Sleep data may also be evaluated from Fitbit devices.
Sodium nitroprusside infusions above 2 mcg/kg/min generate cyanide ion (CN¯) faster than the body can normally dispose of it. At the maximum recommended infusion rate of 10 mcg/kg/min, the patient’s ability to buffer CN¯ will be exceeded in less than one hour [see Overdose (10)].

Patients with hepatic dysfunction are more susceptible to cyanide toxicity.

An early manifestation of cyanide toxicity is increasing dosage requirements to maintain blood pressure control. Metabolic acidosis may not be evident for more than an hour after toxic cyanide levels accumulate.

If cyanide toxicity develops, discontinue sodium nitroprusside, and consider specific treatment of cyanide toxicity [see Overdosage (10)].
The invention provides a hyaluronic acid-based magnetic resonance contrast agent, a preparation method and application thereof, and belongs to the technical field of medical imaging. By a means ofThe magnetic resonance contrast agent is a hyaluronic acid-based polymer, and the structure of the polymer is shown as a formula (I). The relaxation rate of the liver fibrosis specific MRI imaging contrast agent HTCDGd is 3 times that of a clinical small molecule DTPA-Gd. Pharmacokinetic analysis, MRI and fluorescence imaging confirm that HTCDGd circulates in vivo for long periods of time and accumulates efficiently in the liver. For diagnosis of liver fibrosis, HTCDGd shows excellent fibrosis tissue targeting capability, not only provides difference of different degrees of liver fibrosis tissue strengthening degree and longer imaging window observation period through MRI enhancement, but also can directly display morphological characteristics of different degrees of liver fibrosis, and early diagnosis and accurate stage of liver fibrosis are realized. These results indicate that HTCDGd has great potential in detecting and accurately monitoring changes in liver fibrosis as a non-invasive examination method.
In an approach to predictive contact tracing, a computer receives a query associated with contact tracing of a person with an infection. A computer retrieves timestamped location data associated with the person over a period of time. Based on the retrieved data, a computer creates a contact graph associated with the person, where the contact graph depicts one or more other people that were in contact with the person over the period of time. A computer retrieves medical data associated with the person and the one or more other people that were in contact with the person over the period of time. Based on the retrieved data, a computer builds a probabilistic model. A computer runs the probabilistic model to provide a prediction of a probability of infection of the one or more other people over the period of time as a result of being in contact with the person.
The level of stroke-related upper limb motor impairment varies widely among individuals, from mild to severe. Because of this heterogeneity, rehabilitation interventions are tailored individually. In recent years, many studies have been published on the effectiveness of add-on non-invasive neuromodulation methods such as transcranial magnetic stimulation (TMS) or transcranial direct current stimulation in the treatment of stroke-related upper limb motor impairment. There has been A-level evidence for the effectiveness of inhibitory rTMS of the contralesional M1 hand region in stroke patients in the acute stage. However, it has been reported to be ineffective in the chronic stage. In addition, it has been reported that the patient group benefiting from rTMS is mostly those with moderate to mild motor impairment. It has been reported that contra-lesional hemisphere inactivation impairs paretic upper extremity performance in severely infarcted animals. In humans, contra-lesional hemisphere inactivation has been reported to slow down the reaction time. In contrast, a recent randomized controlled study has reported that ipsilesional excitatory rTMS or contralesional inhibitory rTMS may have positive effects in stroke patients with severe upper limb motor impairment. However, the literature on rTMS in post-stroke rehabilitation is highly heterogeneous in terms of frequency, session duration, location, patient characteristics, and outcome scales, and this ambiguity makes it difficult to adapt rTMS to the clinical practice. In this regard, future studies are needed to determine whether rTMS provides an additional benefit to traditional/task-specific rehabilitation approaches in stroke patients with severe upper limb paresis. The aim of this study is to investigate the effect of inhibitory repetitive transcranial magnetic stimulation applied to the contralesional primary motor cortex, by using the rTMS parameters specified in the current recommendation guide, on motor function, activities of daily living, and quality of life in subacute stroke patients with severe upper limb motor impairment.
The study is a randomized double-blind controlled trial. Patients randomly enter into two treatment groups: 1) the CaHMB group and 2) the placebo group. Treatment allocation is by block randomization, with an one-to-one ratio for CaHMB and placebo. The results are concealed in opaque envelopes. Patients will report their daily diets with an online software. Patients will come for clinic after 4 weeks and 12 weeks, receiving laboratory tests and sarcopenia evaluation, and events of primary and secondary outcomes will be analyzed.
There is significant utility in objectively measuring airflow as subjects, undergoing endoscopic laryngeal surgery, commonly have difficulties with airflow secondary to their stenosis. Easier and quicker quantification will tailor diagnosis and treatment. In order to obtain an objective measure of airflow in these participants, we will place a 20-gauge angiocatheter needle into the airway. The catheter will be in situ for a short duration during several spontaneous and non-spontaneous breaths. This will be achieved via the existing tracheostomy stoma or percutaneously via the cricothyroid membrane. This technique is commonly used to access the muscles of the larynx, however, the primary purpose will be to measure airflow in this setting.
Pseudomonas aeruginosa  flagellin protein recruits the mammalian host sialidase enzyme neuraminidase-1 (NEU1) to remove sialic acid residues from the extracellular domain of the mammalian cell-surface protein MUC1 (MUC1-ED), thereby exposing a cryptic binding site on the MUC1-ED protein backbone for flagellin binding. NEU1-driven MUC1-ED desialylation rapidly increases  P. aeruginosa  adhesion to the airway epithelium. MUC1-ED desialylation also increases MUC1-ED cleavage and shedding from the cell surface, where desialylated, shed MUC1-ED competitively blocks  P. aeruginosa  adhesion to cell-associated MUC1-ED. Presented herein are data showing that exogenously-administered, deglycosylated MUC1-ED peptides reduced adhesion of  P. aeruginosa  to airway epithelial cells. Also presented are data showing that administration of  P. aeruginosa  to mice in combination with deglycosylated MUC1-ED decreased  P. aeruginosa  recovered from the lungs at 48 hr and 72 hr post-infection. Such findings are extended to the methods of treatment and prevention of bacterial infections defined herein.
The eight week outpatient study will compare the efficacy and side effect profile of cannabis (3.7%THC/5.6%CBD) and dronabinol. We will also perform a human laboratory experiment evaluating driving using the same study medications that subjects received during their 8 week outpatient treatment.
A radiation therapy system may be provided. The system may include a therapeutic device. The therapeutic apparatus may include: a radiation source for directing therapeutic radiation to at least a portion of a region of interest (ROI) of a subject; and a fixing device for fixing the object. The system may obtain characteristic information of the object. The system may preheat the fixture based on a predictive model for processing characteristic information of the object. The system can send a control signal to the treatment apparatus to apply therapeutic radiation to at least a portion of the ROI fixed by the preheated fixture while the fixture is preheated to a particular temperature.
About 37 million people in the United States have chronic kidney disease, a disease that encompasses multiple causes. About 10% or more of kidney diseases in adults and as many as 70% of selected chronic kidney diseases in children are expected to be explained by genetic causes. Despite the advances in genetic testing and an increasing understanding of the genetic bases of certain kidney diseases, genetic testing in nephrology lags behind other medical fields. More understanding of the benefits and logistics of genetic testing is needed to advance the implementation of genetic testing in chronic kidney diseases. Accordingly, the National Kidney Foundation convened a Working Group of experts with diverse expertise in genetics, nephrology, and allied fields to develop recommendations for genetic testing for monogenic disorders and to identify genetic risk factors for oligogenic and polygenic causes of kidney diseases. Algorithms for clinical decision making on genetic testing and a road map for advancing genetic testing in kidney diseases were generated. An important aspect of this initiative was the use of a modified Delphi process to reach group consensus on the recommendations. The recommendations and resources described herein provide support to nephrologists and allied health professionals to advance the use of genetic testing for diagnosis and screening of kidney diseases.
The invention discloses a preparation method and application of medical gynecological lotion containing stem cell bacteriostatic factors, wherein the medical gynecological lotion comprises the following components in percentage by weight: 3-7% of a stem cell bacteriostatic factor solution, 1-3% of catechin, 0.5-2% of berberine, 0.5-2% of allicin, 1-3% of carbomer, 2-6% of glycerol, 1-3% of vitamin E acetate and purified water. The invention takes stem cell bacteriostatic factors and traditional Chinese medicine monomers as main active ingredients, has small irritation to skin, is not easy to cause anaphylactic reaction, has no toxicity, no residue, safety and effectiveness. The stem cell bacteriostatic factor has the functions of resisting inflammation and resisting infection through the synergistic action of the stem cell bacteriostatic factor and the antibacterial active ingredients. The allicin, the catechin and the berberine have definite antibacterial activity, can be synergistically enhanced by multiple components, particularly have different degrees of inhibition effects on various microorganisms by acting on multiple paths of bacterial metabolism and multiple processes of producing pathogenicity by bacteria by the berberine. The invention mainly forms a layer of protective film on the vaginal wall to physically isolate the vaginal wall from external bacteria, thereby preventing pathogenic microorganisms from planting. It is suitable for treating symptoms caused by cervicitis and vaginitis, such as vaginal congestion, pruritus, pain, and increased secretion.
Ulcerative colitis (UC) is a chronic recurrent inflammatory disease affecting the rectum and colon. Numerous epidemiological studies have identified smoking as a protective factor for UC. Dysbiosis of intestinal microbiota and release of inflammatory factors are well-established characteristics associated with UC. Therefore, we have observed that nicotine exhibits the potential to ameliorate colitis symptoms in UC mice. Additionally, it exerts a regulatory effect on colonic microbiota dysbiosis by promoting the growth of beneficial bacteria while suppressing harmful bacteria. Combined in vivo and in vitro investigations demonstrate that nicotine primarily impedes the assembly of NLRP3, subsequently inhibiting downstream IL-1β secretion.
A system and method for risk prediction and corrective action for a contact type activity is provided. The method includes generating a personalized full body musculoskeletal model to depict the knee and ankle joint behavior of a subject during the contact type activity. Various contact type activities are simulated using the personalized full body musculoskeletal model. Injury biomarkers and their parameters based on the contact type activities are identified, parameters are indicative of risk of injury to participating muscle groups said activity. Based on the injury biomarkers, optimal muscle co-activation parameters are analyzed by a neuro-muscular controller, to adapt the participating muscle groups for providing the correction action against the predicted risk of injury. Said optimal muscle co-activation parameters are indicative of muscle synergy during the contact type activity.
People with intellectual disabilities experience overall poorer health and healthcare access than the general population. It is largely unknown how this applies to asthma and chronic obstructive pulmonary disease (COPD) management by general practitioners (GPs). In a 10-year retrospective matched cohort study, n = 34,429, we examined year prevalence of asthma and COPD in adult patients with and without intellectual disabilities and potential differences in the delivery of asthma and COPD disease management activities in Dutch general practices (2010-2019). We collected information on patient characteristics, comorbidity, consultation patterns, use and outcomes of asthma/COPD control questionnaires, spirometry measurement, pulmonology referrals, and prescribed medication. Asthma patients with intellectual disabilities suffered more frequently from obesity (53.2% vs. 39.5% without intellectual disabilities), and both asthma and COPD patients with intellectual disabilities were more frequently current smokers (45.2% vs. 22.1% without intellectual disabilities, and 76.6% vs. 51.4% without intellectual disabilities, respectively). Also, a statistically significant larger number of asthma patients with intellectual disabilities were prescribed antibiotics (69.9% vs. 54.5%). COPD patients with intellectual disabilities, compared with matched controls without intellectual disabilities, received significantly more often either no COPD-related practice consultation at all (respectively 20.8% vs. 8.5%, p = 0.004) or a large number of practice consultations (>31 consultations, respectively 16.7% vs. 5.3%, p = 0.004). For asthma, there was no statistical difference between patients with or without intellectual disabilities regarding the number and type of consultations. The asthma year point prevalence in patients with intellectual disabilities was, from 2014 onward, significantly higher, and in 2019 was 8.7% vs. 6.0% for people without intellectual disabilities. For COPD, it was comparable in both groups. Both asthma and COPD patients with intellectual disabilities appeared considerably younger in age than patients without intellectual disabilities. Our findings warrant further research into the causes of the differences found for asthma and COPD and whether they also infer differences in the quality or the effectiveness of GP disease management, especially for young adults with intellectual disabilities.
The exact mechanism of action of azelaic acid is not known. The following in vitro data are available, but their clinical significance is unknown. Azelaic acid has been shown to possess antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. The antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.

A normalization of keratinization leading to an anticomedonal effect of azelaic acid may also contribute to its clinical activity. Electron microscopic and immunohistochemical evaluation of skin biopsies from human subjects treated with AZELEX® cream demonstrated a reduction in the thickness of the stratum corneum, a reduction in number and size of keratohyalin granules, and a reduction in the amount and distribution of filaggrin (a protein component of keratohyalin) in epidermal layers. This is suggestive of the ability to decrease microcomedo formation.