anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses a fish interferon gene and its uses. A gene represented by SEQ ID NO:1, a protein represented by SEQ ID NO:2. The gene can express obviously in virus-infected cell and stably transplanted interferon gene cell strain. The gene expression product has anti-virus infection function in cultured cell and fish body. The crucian interferon gene can be utilized and developed in prokaryotic, eukaryotic expression system (fish cell expression system and yeast cell expression system). The product can also be used as anti-virus biological agent and pharmaceutical feedstuff additive which is convenient for use and has obvious and take effect quickly.
An Al-Cr alloy vapour deposited product having high corrosion resistance comprises a substrate and an Al-Cr alloy layer deposited thereon containing 1-50 wt % of Cr. The alloy may contain 1-30 wt % Cr and consists mainly of Al, Cr and (-) phase (Al13Cr2). Numerous examples of specific alloys are provided. The Al-Cr alloy may be formed as a second layer over a first layer of Si, Cu, Al-Si alloy, Al or Cr alloy and in one embodiment the Al-Cr alloy is deposited over a Cr deposit layer and the Al-Cr alloy is covered with an Al deposited layer. A ternary or multi-component Al alloy layer may be deposited, the other alloying ingredient preferably being Si or Ti. The alloy layers may be deposited by physical vapour deposition using plural deposition sources, ion plating or sputtering. Plural deposition sources are used to produce deposited layers in which either the chromium content gradually increases with distance across the thickness of the layer such that the Cr content is minimum at the interface between the layer and the substrate metal or the chromium content gradually increases with distance across the thickness of the layer such that the Cr content is maximum at the interface between the layer and the substrate metal. The plated product finds use in automotive exhaust mufflers, store heat reflectors and building materials. The substrste may be steel, Al-alloy or Cu-alloy.
Tangningtongluo tablets, 4 tablets one time,tid,po, taken after meals.The patients will receive drugs for 24 weeks continuously. After 24 weeks, the researchers will decide whether to continue depend on the patient condition and willingness. The maximum medication time is up to 48 weeks.Basic treatment: According to the comprehensive objectives of China Type 2 Diabetes Guidelines (2020 Edition) .The Angiotensin-Converting Enzyme（ACEI） and Angiotensin Receptor Blocker（ARB） drugs will be continued to use as the original treatment protocol.
Patients with atrial fibrillation (AF) have a substantial risk of stroke and systemic embolism. Subclinical AF is often suspected to be the cause of stroke in these patients. The detection of asymptomatic AF episodes is a challenge and the real rate of occurrence of these episodes remains unknown. The rate of stroke is high among patients who have received a pacemaker and this device can detect subclinical episodes of rapid atrial rate, which correlate with electrocardiographically documented AF. The net benefit of anticoagulant treatment is well established in patients with clinical AF but data about anticoagulation for subclinical AF settings is unknown. The aim of this study is to assess the impact of anticoagulant therapy on subclinical AF, directed by cardiac implantable electronic device (CIED) intensive monitoring, on the incidence of stroke and systemic embolism and correlate the AF episodes detected by CIED with thromboembolic events. Methods: This is a prospective, randomized, unicentric, parallel clinical study in patients with an atrioventricular pacemaker, defibrillator, or cardiac resynchronization therapy devices in sinus rhythm and CHADS2 score (an index of the risk of stroke in patients with atrial fibrillation, range from 0 to 6) ≥ 2 . Patients will be randomized to the intervention group - intensive monitoring arm (Group I) or control group - routine schedule arm (Group II) in a 1:1 ratio. Time to inclusion will be 24 months and all patients will be followed up for a period of 36 months. Group I, patients will be submitted to device data collection every 2 months, while in Group II, patients will be managed conventionally. Patients from Group I with episodes of subclinical AF will receive anticoagulant therapy, as well as patients with clinical AF of both arms. Device data from Group II patients will not be analyzed until they achieve the primary endpoint. Primary endpoint: stroke or systemic embolism. Secondary endpoints: subclinical AF rate, total mortality, cardiovascular mortality, myocardial infarction, cardiovascular hospitalization, and bleeding rates. Expected outcome: It is expected that anticoagulation therapy of subclinical AF directed by CIED intensive monitoring will reduce the incidence of stroke and systemic embolism comparing to patients with non-diagnosed subclinical AF.
PROBLEM TO BE SOLVED: To obtain a hair-treating agent composition containing a specific amide compound having a penetration-stimulating action. SOLUTION: This hair-treating agent composition contains at least one kind among compounds of the formula R<1> R<2> NCOR<3> (R<1> -R<3> are each H, a 1-8C alkyl or alkenyl, an aryl) in an amount of 0.1-30wt.%. The compound of the formula includes pentanoamide, and N-butylformamide. The hair-treating agent composition can largely improve the penetration speed or penetration amount of a dye for dyeing hair, a polymer for conditioning hair, a perfume, a softener, an agent for imparting tension or nerve, an agent for enhancing a permanent wave effect, a damage-reducing agent, etc. When the hair-treating agent composition is especially compounded with the dye for dyeing hair, hair can well be dyed. The above compound has a more excellent penetration-stimulating action than benzyl alcohol as a conventional penetration-stimulating agent.
1,163,387. Pyridyl - dihydroisoquinoline derivatives. DR. KARL THOMAE G.m.b.H. 11 March, 1968 [10 March, 1967], No. 11746/68. Addition to 1,070,308. Heading C2C. Pyridylisoquinolines of formula and acid addition salts thereof wherein R 1  and R 2  are C 1-2  alkyl and R 3 , R 4  and R 5  are H or methyl, are prepared by dehydration of a compound of formula The compounds of the last formula above are prepared by the reaction of a pyridine aldoxime and a compound of formula wherein one of X and Y is OH, acyloxy or halogen and Z and the other are H or Y and X or Z is a double bond, the remaining symbol being H, in the presence of a strong acid or a Lewis acid. The 2-pyridyl compounds are novel. Pharmaceutical compositions in conventional forms for oral, rectal, parenteral or topical administration and having antiphlogistic and antipyretic activity comprise an above novel compound and a carrier or excipient therefor.
AIMS: The primary objective of this study was to develop a validated classification system for assessing iatrogenic bone trauma and soft-tissue injury during total hip arthroplasty (THA). The secondary objective was to compare macroscopic bone trauma and soft-tissues injury in conventional THA (CO THA) versus robotic arm-assisted THA (RO THA) using this classification system.
METHODS: This study included 30 CO THAs versus 30 RO THAs performed by a single surgeon. Intraoperative photographs of the osseous acetabulum and periacetabular soft-tissues were obtained prior to implantation of the acetabular component, which were used to develop the proposed classification system. Interobserver and intraobserver variabilities of the proposed classification system were assessed.
RESULTS: The BOne trauma and Soft-Tissue Injury classification system in total Hip arthroplasty (BOSTI Hip) grades osseous acetabular trauma and periarticular muscle damage during THA. The classification system has an interclass correlation coefficient of 0.90 (95% CI 0.86 to 0.93) for interobserver agreement and 0.89 (95% CI 0.84 to 0.93) for intraobserver agreement. RO THA was associated with improved BOSTI Hip scores (p = 0.002) and more pristine osseous surfaces in the anterior superior (p = 0.001) and posterior superior (p < 0.001) acetabular quadrants compared with CO THA. There were no differences between the groups in relation to injury to the gluteus medius (p = 0.084), obturator internus (p = 0.241), piriformis (p = 0.081), superior gamellus (p = 0.116), inferior gamellus (p = 0.132), quadratus femoris (p = 0.208), and vastus lateralis (p = 0.135), but overall combined muscle injury was reduced in RO THA compared with CO THA (p = 0.023).
DISCUSSION: The proposed BOSTI Hip classification provides a reproducible grading system for stratifying iatrogenic bone trauma and soft-tissue injury during THA. RO THA was associated with improved BOSTI Hip scores, more pristine osseous acetabular surfaces, and reduced combined periarticular muscle injury compared with CO THA. Further research is required to understand if these intraoperative findings translate to differences in clinical outcomes between the treatment groups.
PURPOSE:An easily handleable, active, and stable cosmetic containing honey assimilated with a plant essence component having a skin effect extracted from polypore, ginseng, aloe, papaia, seaweed, etc. CONSTITUTION:A cosmetic containing honey assimilated with a plant essence component, obtained by assimilating honey with polypore, ginseng, aloe, papaia, seaweed, oleo-resin of hydrangea tea of India containing Ge, plant essence Ge extracted from it, etc. The cosmetic is rich in skin vitamin such as vitamin B6, nicotinamide, etc. EFFECT:Roughness of hands is reduced, tension and moisture of skin are produced. Wrinkles and stains are made inconspicurous. USE:Especially useful as a base cosmetic.
BACKGROUND/AIMS: Recent research has increasingly focused on the role of the gastric microbiome in the development of gastric cancer. We aimed to investigate the changes in the microbiome during gastric carcinogenesis in structural and functional aspects, with a specific focus on the association between oral and gastric microbiomes.
METHODS: We collected saliva, gastric juice, and gastric tissue samples from 141 patients at different stages of gastric carcinogenesis and processed them for microbiome analysis using 16S rRNA gene profiling. The alpha and beta diversities were analyzed, and the differences in microbiome composition and function profiles were analyzed among the groups, as well as the correlation between changes in the oral and gastric microbiomes during carcinogenesis.
RESULTS: We observed significant differences in microbial diversity and composition between the disease and control groups, primarily in the gastric juice. Specific bacterial strains, including Schaalia odontolytica, Streptococcus cristatus, and Peptostreptococcus stomatis, showed a significant increase in abundance in the gastric juice in the low-grade dysplasia and gastric cancer groups. Notably, the correlation between the oral and gastric microbiota compositions, increased as the disease progressed. Predictive analysis of the metagenomic functional profiles revealed changes in functional pathways that may be associated with carcinogenesis (ABC transport and two-component systems).
CONCLUSION: During gastric carcinogenesis, the abundance of oral commensals associated with cancer increased in the stomach. The similarity in microbial composition between the stomach and oral cavity also increased, implying a potential role of oral-gastric bacterial interactions in gastric cancer development.
Active 10 Herz rTMS with intensity of 120% of the resting motor threshold recorded from the right first dorsal interosseus will be administered over the left DLPFC. Therapy will include 20 sessions (one session in each of 20 consecutive working days - four weeks in total). In every session 3000 magnetic pulses over the left DLPFC will be elicited.
OBJECTIVE: It is well known that glucose and lipid metabolism disorders and insulin resistance are common in sepsis, which affect the occurrence and prognosis of multiple organ dysfunction in septic patients. Previous study reported the predictive value of triglyceride-glucose index (TyG), a clinical indicator for insulin resistance, in postoperative delirium patients. However, it remains unclear whether the TyG index is a novel predictive biomarker for sepsis-associated delirium. The aim of this study is to explore the relationship between TyG index and the risk of delirium in patients with sepsis.
METHODS: Adult septic patients were identified from the MIMIC-IV database and divided into four groups based on the mean value of TyG. The primary outcome was the incidence of delirium. The association between TyG and the risk of developing delirium was evaluated by restricted cubic spline (RCS), multivariate logistic regression and subgroup analysis. Propensity Score Matching (PSM) method was used to balance the baseline data.
RESULTS: A total of 3,331 septic patients were included in the analysis, and further divided into four groups: Q1 (TyG ≤ 8.67), Q2 (8.67 < TyG ≤ 9.08), Q3 (9.08 < TyG ≤ 9.61), and Q4 (TyG > 9.61). The RCS curves demonstrated a non-linear positive relationship between TyG index and the risk of developing delirium, and an optimal cut-of value 9.09 was recommended. After balancing the baseline information by PSM, patients in the TyG > 9.09 group had a significant higher incidence of delirium compared with those in the TyG ≤ 9.09 group. In logistic regression analysis, TyG > 9.09 was significantly associated with lower risk of developing delirium in both original cohort (OR 1.54-1.78, all P < 0.001) and the PSM cohort (OR 1.41-1.48, all P < 0.001). No association was found between the TyG index and mortality (all P > 0.05). In subgroup analysis, our findings were consistent (all OR > 1 in all subgroups).
CONCLUSION: Our study demonstrated an independent association between TyG index and increased risk of delirium in septic patients, indicating that TyG index can serve as a biomarker for delirium in sepsis.
The invention provides a production method of a silk quilt for preventing and treating rheumatoid arthritis, which relates to health-care products, in particular to the production technology of a functional silk quilt. The production method comprises the following steps: firstly, decocting snow lotus, radix codonopsitis, basil, radix cynanchi bungei, earthworm, folium ginkgo, jujube, angelica, cassia bark, tuckahoe and eucommia bark in water, and filtering to obtain Chinese herbal medicine liquid; then adding a raising agent, a silk softening agent and the Chinese herbal medicine liquid to silk floss; and baking and curing to form silk floss containing medicines. The health-care silk quilt produced by the method has a shape identical to that of a prior silk quilt, and has the characteristics of an original silk quilt. Silk fibers have the characteristics of high rebound elasticity, bulkiness and flexibleness, and strong gas permeability and moisture permeability. The silk quilt has the advantages of scurf hiding prevention, no acarid breeding, no dust absorption and no floss generation from the inside. Because the silk quilt with the functions of conditioning and treatment is formed by adding Chinese herbal medicines and using the unique technical method, the microcirculation of organisms can be regulated; in addition, assisted with the smell of the Chinese herbal medicines, the medicines can be better absorbed by human bodies to relieve symptoms; and the treatment effect is obvious after the silk quilt is used for a long time.
The goal of this project was to quantify the impact of visual acuity impairment on socialization and physical function of nursing home residents, and to determine the cost effectiveness of a visual impairment intervention program designed to enhance access to eye care services. To accomplish these aims, the investigators enrolled a complete sample of visually impaired persons from 28 nursing homes in the Lower Eastern Shore of Maryland and Delaware. From the same facilities, the investigators also enrolled a random sample of non-visually impaired residents, with sample size equal to the sample of visually impaired. The group of visually impaired residents was randomized (by facility) to an intervention program or "usual care" group. The intervention program facilitated the utilization of eye care services of the three main causes of visual impairment: refractive error, cataract, and low vision associated with age-related eye diseases. All study groups provided data at baseline, six and twelve months from intervention, and data on eye care utilization, hospitalizations, use of psychoactive medications and mortality collected every other month (bi-monthly). Patients had a screening test of visual acuity, using standard letter/symbol charts, and grating charts. The mental status was tested using the MiniMental State Examination. Social function, physical function, and mobility were assessed through questionnaires asked of nursing home staff familiar with the patient, and the questions were modeled on the Minimum Data Set questions or specially designed for nursing home residents.

The investigators compare the mobility scores, and socialization scores, of nursing home residents with visual loss randomized to the intervention homes to the scores of nursing home residents with visual loss randomized to control homes. The investigators use the mobility and socialization scores of those without visual loss at baseline and follow up to compare with the trajectory of decline in those with visual loss.
Photopolymerisable compsn. for dentistry contains (a) a photopolymerisable monomer, esp. a dimethacrylate, (b) a photo-catalyst which causes complete monomer polymerisation up to a layer thickness of several mm. by continuous irradiation in wave-length 3000-4200 angstroms, (c) a radical-forming thermal catalyst and (d) an accelerator which activates the thermal catalyst, so that the monomer polymerises already at room temp. also without irradiation by UV light. The polymerisation velocity caused by catalyst (c) and accelerator (d) is smaller by at least 2 power factors compared to the case when the photo-polymerisable compsn. is irradiated up to a thickness of 1 mm with radiation having wave-length 3600 angstroms and power density 100 mW/cm2. Compsn. is used filling material for cavities and for building up edges. After mixing components (a) and (b), the compsn. can be worked for several hrs. in a low-viscosity condition. Moment of pre-hardening is arbitrarily determined by UV irradiation and can be carried out within a few secs.
The 16-week treatment group will contain 3 blocks of treatment (exposure, cognitive, skills) with order randomized within the treatment. The first and last group session are considered inactive treatment sessions. The group treatment will be provided weekly.
The objective of this proposal is to test the clinical practicality of a new technology; cone beam imaging, for verification of treatment set up accuracy of cancer patients receiving radiation therapy. Currently, treatment accuracy is checked via use of 2-dimensional projection x-rays taken with the megavoltage treatment beam and electronic portal imaging devices (EPID). Typically 2 orthogonal portal images are obtained to confirm patient positioning accuracy. This method of treatment verification, however, usually provides images of poor quality and lacks true 3D information, thus making it difficult for the radiation oncologist to definitively confirm treatment accuracy. New generation EPIDs are capable of obtaining higher quality images at significantly lower imaging doses. Thus, for the same total imaging dose new generation EPIDs permit acquisition of many projection images rather than just 2 or 3. The combination of more images and higher quality images should permit more definitive assessment of treatment accuracy. We propose here to test the clinical practicality and reliability of a new prototype portal imaging system.
Patients receive efatutazone dihydrochloride PO BID continuously. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Musculoskeletal system problems are a common health issue among individuals working in textile workshops. The causes of these problems include ergonomic risks in working conditions, personal characteristics of employees, and other workplace factors. Ergonomic risks are the most significant cause of musculoskeletal system problems in textile workshops. These risks can stem from factors such as the working positions of employees, equipment used, and the nature of the work itself. For example, factors like prolonged static postures, lifting and carrying heavy objects, performing repetitive movements, and using poorly designed equipment can contribute to musculoskeletal system problems. Personal characteristics of employees can also increase the risk of musculoskeletal system problems. For instance, employees who start working at a young age, are overweight, have poor posture habits, or smoke are more susceptible to these problems. Other workplace factors can also contribute to musculoskeletal system problems. Factors like poor ventilation, noise, and lighting can adversely affect the musculoskeletal system of employees. These problems typically manifest with symptoms such as pain, loss of strength, numbness, tingling, and swelling. In some cases, they can lead to more serious issues such as muscle tears and osteoarthritis. Common problems among individuals working in textile workshops include neck pain, back pain, shoulder pain, wrist pain, hand and finger pain, knee pain, and foot pain. These problems negatively impact the functionality and quality of life of individuals working in textile workshops.

The aim of the research is to examine the impact of an online rehabilitation program applied to individuals working in textile workshops on pain and quality of life. The desired outcome of the research is for the online rehabilitation program applied to individuals working in textile workshops to reduce pain symptoms and increase their quality of life.
Control arm: Patients will be assigned to a consultation model of CKD care which consists of clinic reviews by a nephrologist, which is as per current standard of care. The frequency of reviews, which is at the discretion of the nephrologist, is typically scheduled at 4 to 6 monthly intervals. Each consultation lasts an average of 10 to 15 minutes.
PURPOSE:To obtain a porous base material readily controllable in the pore size, outstanding in strength and slow-release characteristics, by reaction between polylactide, polyglycolide or copolycondensate therefrom and aluminum alcoholate. CONSTITUTION:(A) A solution prepared by dissolving, in an organic solvent (e.g. chloroform), polylactide, polyglycolide or copolycondensate therefrom with a number-average molecular weight 300-200,000 derived from direct dehydration polycondensation of, e.g. lactic acid and/or glycolic acid, under reduced pressure, with a polymer concentration 0.5-40wt% is incorporated with, while stirring, (B) a second solution prepared by dissolving, in an organic solvent, an aluminum alcoholate such as aluminum isopropoxide, with a concentration up to 10wt% to carry out reaction. Following completion of the reaction, the resulting gelled product is dried under reduced pressure, thus obtaining the objective porous base material. The pore size can be regulated by controlling the molecular weight and/or concentration of the polymer in the component A.