anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Few studies have explored the feasibility of online language interventions for young children with Down syndrome. Additionally, none have manipulated dose frequency or reported on the use of music as a medium through which language and sign can be learned.
PURPOSE: The purpose of this study was to (a) examine the feasibility and acceptability of an online language through music intervention for young children (1-3;6 years) with Down syndrome and (b) compare effectiveness at two intervention dose frequencies.
METHOD: The study was carried out in two phases using a mixed-methods design. Phase 1: Qualitative data were gathered from parents to examine feasibility when implementing a video-based language intervention. Phase 2: Seventy-six families participated in an online language intervention at home. Effectiveness was examined comparing two groups, randomly assigned to a high and low dose frequency. The Down Syndrome Education (DSE) checklists (combined) were the primary outcome measure. Process data were gathered to determine intervention acceptability in practice and to identify factors that would improve successful future implementation. Acceptability data were analyzed with reference to the theoretical framework of acceptability (Version 2).
RESULTS: Forty-three parents completed the Phase 1 scoping questionnaire, five of whom took part in focus groups. Once weekly morning sessions were indicated as the preferred scheduling choice. Phase 2 quantitative data were analyzed using beta regression adjusted for baseline scores and indicated no additional benefit to receiving the higher dose. However, exploratory interaction models suggested that the efficacy of the high-dose intervention was higher (than low-dose intervention) in participants with higher baseline DSE performance. Parents perceived the intervention to be effective and positive for the family.
CONCLUSION: The results add to our knowledge of real-world effective online interventions and suggest that a critical minimum language level is required for children with Down syndrome to benefit optimally from a higher intervention dose frequency.
SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25979704.
BACKGROUND: Arachnoid cysts (ACs) are benign lesions typically believed to not cause neurologic defects in the adult population and are most often found incidentally on imaging. We describe 2 patients with ACs potentially leading to isolated cranial nerve (CN) dysfunction.
METHODS: We describe 2 patients, 1 with a fourth nerve palsy and the other with a sixth nerve palsy found to have ACs on MRI brain imaging in locations that potentially caused a compressive CN palsy. We review previous literature of ACs presenting with CN III, IV, or VI palsy.
RESULTS: Patient 1 was a 62-year-old man who presented with a 22-year history of diplopia with strabismus examination consistent with a congenital CN IV palsy. Despite multiple surgeries, his CN IV palsy insidiously worsened. An AC in the posterior fossa with mass effect on the quadrigeminal plate and asymmetric atrophy of the right superior oblique was identified on imaging. Patient 2 was an 80-year-old man who presented with an 18-year history of diplopia and was found to have a left esotropia and abduction deficit consistent with complete CN VI palsy. An AC in the left cavernous sinus was identified on imaging. He underwent strabismus surgery with satisfactory resolution of diplopia. We identified a total of 18 previously published cases: 8 reports of CN III palsy, 4 reports of CN IV palsy, and 6 reports of CN VI palsy. Patient ages ranged from 1 to 67 with a median of 34.5. In 16/18 (89%) cases, the diagnosis of ACs was made within 1 year of symptom onset. Surgical removal of the AC was successful in resolving diplopia in 7/12 (58%) cases. In no case was strabismus surgery performed as primary treatment.
CONCLUSIONS: Although ACs are typically congenital asymptomatic lesions, we present a case series of 2 patients with ACs in anatomic locations that potentially caused chronic, progressive, isolated CN palsies leading to strabismus. Our literature review revealed that most published cases detailing this clinical scenario resulted in neurosurgical fenestration of ACs with mixed results. Our cases represent 2 patients with AC-associated CN palsy treated with strabismus surgery.
The object of the present invention is an agent for the oxidative colouring of hair containing at least one coupling substance of general formula (I) in which R is a straight-chained or branched C1? to C4?-alkyl radical, X is chlorine or fluorine and R?1 is a straight-chained or branched C1? to C4?-alkyl radical or a straight-chained or branched C2? to C4?-hydroxyalkyl radical, and novel 5-halogen-2,4-bis(alkylamino)-1-alkylbenzols. The coupling substances of formula (I) are obtainable by simple chemical reactions, easily water-soluble and, especially as a component of the hair colorants described here, have a good shelf life. The colour results obtained with the hair colorants of the invention are characterized especially by the colour intensity of the red hues and good colour purity in the blue hues, besides the large range of tints.
Participants with localized resectable disease receive Cycle 1 of bevacizumab 3 days before chemotherapy with cisplatin and doxorubicin. Subsequent cycles consist of bevacizumab on the first day of chemotherapy, then cisplatin, and doxorubicin, or methotrexate. If applicable, definitive surgery and assessment of histologic response will occur at week 10 followed by bevacizumab on the first day of chemotherapy with cisplatin and doxorubicin, or methotrexate.
Patients in this arm receive Hou Gu Mi Xi, with oral dose of 30 g/day (contain 10.1 herb materials) during entire follow up period (2 years). HGMX is composed of 10 dietary Chinese herbs (including ginseng (Renshen), tuckahoe (Fuling), coixenolide (Yiyiren), Chinese yam (Shanyao), lotus seed (Lianzi), amomum (Sharen), platycodon (Jiegen), white hyacinth bean (Baibiandou), licorice (Gancao), and orange peel (Jupi)), early rice, and oats.
Patients will recieve Low-dose Venetoclax at a dose of 100mg/day por 21 days, oral itraconazol 100mg every 12 hours, and subcutaneous Azacitidine 75mg/m2 (maximun dose 100mg) daily for seven days. Each cycle duration is 21 days and patients will recieve a maximun of two cycles.
The invention discloses a kind of blue crab's blood recombinant protein and PtHc-640.2 gene and application thereof. Belongs to the technical field of molecular biology. The nucleotide sequence of the PtHc-640.2 gene of the portunus trituberculatus is shown as SEQ ID No.1, and the amino acid sequence of the coded hemocyanin recombinant protein is shown as SEQ ID No. 2. In vitro bacteriostasis experiments prove that the bacteriostasis rates of the blue recombinant protein of the blue portunus trituberculatus at the concentrations of 0.01, 0.02 and 0.03 mg/mL are 19 percent, 30 percent and 48 percent respectively, and the blue recombinant protein of the blue portunus trituberculatus has remarkable inhibition effect on the growth of vibrio parahaemolyticus. Therefore, the invention lays a foundation for disease control and gene auxiliary breeding of portunus trituberculatus and has potential application value in the aspects of development of antibacterial drugs, feed additive production and the like.
Patients who received NACT were enrolled on the study depending on their order of admission. NACT regimen was 4 cycles of anthracycline and cyclophosphamide with 12 cycles of taxane based regimen. Trastuzumab for 12 monhts was also added if pathologically human epidermal growth factor receptor 2 (HER2+). This protocol was the same as planned for postoperative protocol and it was decided by the medical oncologist of the patient. Pathologic complete response (pCR) was defined as no residual invasive or in-situ tumor in the final pathology following neoadjuvant treatments. Clinical complete response (cCR) was defined as no sign of residual tumor mass and The Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria's were used to determine cCR. Patients were evaluated for clinical response between 4 and 6 weeks after the end of last NART. We waited as long as the NART period for clinical response evaluation of the cases.

Every patient was discussed in the preoperative multidisciplinary breast surgical oncology meeting before and after neoadjuvant treatment. The method of surgery was discussed in these meetings by a group of expert breast surgeons, plastic and reconstructive surgeons, radiation oncologists, medical oncologists, and radiologists. Patients were specifically evaluated for breast conservation, mastectomy or mastectomy with reconstruction. Likewise, the method of axillary surgery also discussed in these meetings. Indications for mastectomy were initially multi-centric tumors, large tumor volume relative to breast volume that is not allowing a good cosmetic result, patients with breast cancer related gene mutations, extensive in-situ component. Reconstruction with implant was also recommended to all mastectomy patients.

Radiotherapy was delivered via 4-6 megavoltage (MV) X-ray beam energies and Intensity Modulated Radiation Therapy (IMRT) or Volumetric Modulated Arc Therapy (VMAT) or forward planning IMRT (field in field - FinF) treatment techniques. NART was planned as 42.5 gray (Gy) in 16 fractions (with 10 Gy in 5 fractions sequential boost doses) or 50 Gy in 25 fractions (with 10 Gy in 5 fractions sequential boost doses) or 50.4 Gy in 28 fractions (with 59.9 Gy in 28 fractions simultaneous integrated boost doses) the whole breast irradiation plus nodal irradiation (including supraclavicular and axillary lymph nodes - Level I, II, III), if breast conserving surgery (BCS) is planned. If mastectomy is scheduled following NART, irradiation was planned with the same treatment volumes (the whole breast irradiation plus nodal irradiation) and doses like in BCS, but boost dose delivery was left to the radiation oncologist's preference. Radiotherapy to the mammary internal lymph nodes was delivered upon discretion of the radiation oncologist, and according to the tumor characteristics such as clinical stage or tumor location. Surgery was planned six weeks after the end of NART.
Participants with moderate renal impairment (eGFR 30 to \<60 mL/min) will be enrolled. Participants will receive a single SC dose of JNJ-64565111 on Day 1.
In some embodiments the present invention provides methods and compositions for inducing the formation of de novo tertiary lymphoid structures in subjects. In some embodiments such methods comprise administering an IL33 protein to a subject. In some embodiments the subjects have cancer. In some embodiments the subjects have a chronic inflammatory condition. In some embodiments the present invention provides methods for treating cancer. In some embodiments the present invention provides methods for treating chronic inflammatory conditions.
OBJECTIVE: We determined the prevalences of hyperoxemia and excessive oxygen use, and the epidemiology, ventilation characteristics and outcomes associated with hyperoxemia in invasively ventilated patients with coronavirus disease 2019 (COVID-19).
METHODS: Post hoc analysis of a national, multicentre, observational study in 22 ICUs. Patients were classified in the first two days of invasive ventilation as 'hyperoxemic' or 'normoxemic'. The co-primary endpoints were prevalence of hyperoxemia (PaO2 > 90 mmHg) and prevalence of excessive oxygen use (FiO2 ≥ 60% while PaO2 > 90 mmHg or SpO2 > 92%). Secondary endpoints included ventilator settings and ventilation parameters, duration of ventilation, length of stay (LOS) in ICU and hospital, and mortality in ICU, hospital, and at day 28 and 90. We used propensity matching to control for observed confounding factors that may influence endpoints.
RESULTS: Of 851 COVID-19 patients, 225 (26.4%) were classified as hyperoxemic. Excessive oxygen use occurred in 385 (45.2%) patients. Acute respiratory distress syndrome (ARDS) severity was lowest in hyperoxemic patients. Hyperoxemic patients were ventilated with higher positive end-expiratory pressure (PEEP), while rescue therapies for hypoxemia were applied more often in normoxemic patients. Neither in the unmatched nor in the matched analysis were there differences between hyperoxemic and normoxemic patients with regard to any of the clinical outcomes.
CONCLUSION: In this cohort of invasively ventilated COVID-19 patients, hyperoxemia occurred often and so did excessive oxygen use. The main differences between hyperoxemic and normoxemic patients were ARDS severity and use of PEEP. Clinical outcomes were not different between hyperoxemic and normoxemic patients.
Adolescence and Youth is a critical period for psychological quality training and personality shaping, and their mental health has always been the focus of health management for this population. With the rapid development of short videos and self-media, watching "Mukbang" is a behavioral way for these people to relieve anxiety, depression and other mental health problems. But watching "Mukbang" behaviors may have Internet addiction, and there is a high comorbidity rate between Internet addiction and mental health disorders. "Mukbang" is a newly developed online entertainment method. Its helpfulness in reducing psychological stress, relieving depression and other negative emotions, and the mechanism of action that aggravates the risk of Internet addiction is unknown. At present, the new crown epidemic is spreading all over the world, and the stress reactions such as fear, anxiety, sadness and anger brought to teenagers and young people will induce more psychological problems; and closed management has greatly increased the risk of such people. Internet addiction time, the detection rate of Internet addiction has also greatly increased, resulting in a serious vicious circle. Based on the theory of use and satisfaction, this research will adopt an exploratory time-series mixed design. First, qualitative research is used to explore the possible reasons and related experience of adolescents and young people watching "eating and broadcasting"; Potential related variables and quantitative indicators of watching "eating and broadcasting" behavior, further verify the correlation between "eating and broadcasting" behavior, Internet addiction and mental health; and explore the role of "eating and broadcasting" video watching behavior in mental health and Internet addiction. mediation between them. It provides a theoretical basis for promoting the healthy and psychological development of adolescents and young people, standardizing the management of "eating and broadcasting" videos, and correcting the correct guidance for preventing addiction to the Internet.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to method of evaluation of snake venom for the presence or absence of platelet aggregation reaction (PA1) based on specific binding with receptors, purified and isolated PA1 from snake venom or its truncated form, method of isolation of PA1 from snake venom and pharmaceutical composition based on said. Invention involves method of assay of ability of snake venom to inhibit platelet aggregation, method of purification of inhibitor of platelet activity from different snake venom samples, its characterization and truncated form containing modified lysine residue that inhibits specifically binding fibrinogen or von Willebrand factor with GPIIb-IIIa. Obtained therapeutic agents are able to block or inhibit thrombus formation without hemostasis danger. EFFECT: improved method of assay, enhanced effectiveness of composition. 45 cl, 3 tbl, 51 dwg
Asthma exacerbations represent an acute or sub-acute worsening in symptoms and lung function from the patient's usual status. Early detection of exacerbations is a major public health issue. In clinic, management of asthma involves asthma control questionnaires and pulmonary function tests (Forced Expiratory Volume (FEV1), Fractional exhaled nitric oxide or FeNO). At home, the peak expiratory flow rate (PEFR) measured by the peak flow meter is an aid to monitor asthma but its ability to predict asthma exacerbations remains controversial. Anharmonic morphological analysis of the respiratory signals (AMARS) is a new morpho-mathematic biomarker that produces objective and accurate measures of the shape of the ventilatory flow. The current study aims at monitoring the resting spontaneous breathing at home in asthmatics. Changes in AMARS may be a predictor of early symptoms of asthma exacerbations. We will recruit 120 asthmatic patients. Patients will be given a portable device for telemonitoring. Resting spontaneous breathing will be measured during 2-3 min in the morning and in the evening, twice a week at least for 12 months. Three visits will be scheduled in Clinical Investigation Center before (V1), after 6-month (V2) and 12-month (V3) telemonitoring period.
The present invention is an apparatus for detecting and treating bruxism.  The apparatus of the invention comprises a sensing unit, a calculation unit and a stimulation unit. The sensing unit is in charge of measuring the interocclusal distance and reporting this distance to the calculation unit. After receiving the information from the sensing unit, the calculation unit archives and processes the information to determine if the sensing event is a bruxism event. When a sensing event is confirmed as a bruxism event, the calculation unit selects an adequate stimulation and sends a request to the stimulation unit, which applies the selected stimulation. The apparatus of the present invention may be suitable for treating both diurnal and nocturnal bruxism and the intrabuccal components may be removed from the mouth when bruxism events are not expected to occur, i.e., during the day for an individual who suffers only from nocturnal bruxism.
Epilepsy diagnosis is often delayed or inaccurate, exposing people to ongoing seizures and their substantial consequences until effective treatment is initiated. Important factors contributing to this problem include delayed recognition of seizure symptoms by patients and eyewitnesses; cultural, geographical, and financial barriers to seeking health care; and missed or delayed diagnosis by health-care providers. Epilepsy diagnosis involves several steps. The first step is recognition of epileptic seizures; next is classification of epilepsy type and whether an epilepsy syndrome is present; finally, the underlying epilepsy-associated comorbidities and potential causes must be identified, which differ across the lifespan. Clinical history, elicited from patients and eyewitnesses, is a fundamental component of the diagnostic pathway. Recent technological advances, including smartphone videography and genetic testing, are increasingly used in routine practice. Innovations in technology, such as artificial intelligence, could provide new possibilities for directly and indirectly detecting epilepsy and might make valuable contributions to diagnostic algorithms in the future.
BACKGROUND: Management of vasospastic and vaso-occlusive disorders is a complex challenge, with current treatments showing varied success. Cannabinoids have demonstrated both vasodilatory and antifibrotic properties, which present potential mechanisms for therapeutic relief. No existing review examines these effects in peripheral circulation in relation to vasospastic and vaso-occlusive disorders. This study aims to investigate vasodilatory and antifibrotic properties of cannabinoids in peripheral vasculature for application in vasospastic and vaso-occlusive disorders affecting the hand.
METHODS: A systematic search was conducted by 2 independent reviewers across PubMed, Cochrane, Ovid MEDLINE, and CINAHL to identify studies in accordance with the determined inclusion/exclusion criteria. Information regarding study design, medication, dosage, and hemodynamic or antifibrotic effects were extracted. Descriptive statistics were used to summarize study findings as appropriate.
RESULTS: A total of 584 articles were identified, and 32 were selected for inclusion. Studies were grouped by effect type: hemodynamic (n = 17, 53%) and antifibrotic (n = 15, 47%). Vasodilatory effects including reduced perfusion pressure, increased functional capillary density, inhibition of vessel contraction, and increased blood flow were reported in 82% of studies. Antifibrotic effects including reduced dermal thickening, reduced collagen synthesis, and reduced fibroblast migration were reported in 100% of studies.
CONCLUSION: Overall, cannabinoids were found to have vasodilatory and antifibrotic effects on peripheral circulation via both endothelium-dependent and independent mechanisms. Our review suggests the applicability of cannabis-based medicines for vasospastic and vaso-occlusive disorders affecting the hand (eg, Raynaud disease, Buerger disease). Future research should aim to assess the effectiveness of cannabis-based medicines for these conditions.
PURPOSE:To obtain a granular agent for dental metal coating, by carrying out the calcination and pulverization process of the mixture of fine gold powder and porcelain component at a specific ratio, at least once, thereby equalizing the ratios of the gold and the additive in each fine particle to those of the raw material. CONSTITUTION:A mixture of 50-75wt% fine gold powder and at least one kind of porcelain component is calcined at a temperature lower than the melting point of the gold, and pulverized. The calcination and pulverization process is carried out at least once to obtain the objective fine granules for metal coat ing having a diameter of 20-50mum. The ratios of the gold and the porcelain component constituting each fine particle are made to be equal to the mixing ratios of the raw material by this process. The fine powder of gold is preferably particles having a diameter of <=10mum. EFFECT:The metal cast surface is integrated to the metal coating agent, and the mechanical bonding force can be increased. USE:An agent for bonding a metal with a porcelain material in the preparation of a porcelain crown in dental work.
In a double-blind placebo-controlled between-subject experimental design, 60 adult male subjects will be randomly allocated to receive either intranasal oxytocin (24IU, n= 30) or placebo (n = 30) nasal spray. 45 minutes after treatment the participants will undergo a naturalistic fear induction paradigm during fMRI. During the paradigm video clips of 25s lengths will be presented showing fear-inducing situations in social and non-social contexts as well as corresponding control video clips. Following each clip subjects are required to rate their level of subjective fear on a rating scale ranging from 1 (no fear) to 9 (highest fear). Participants will undergo screening for psychopathological and emotional states before treatment. Together with a randomized assignment to the treatment groups, this will allow controlling for confounding between-group differences.