anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Tumor budding (TB) has been associated with poor survival in a variety of cancers including intrahepatic cholangiocarcinoma (iCCA). As tumor histomorphological features are significantly altered after neoadjuvant therapy (NAT), our study aims to assess the prognostic significance of TB in iCCA patients before and after NAT, by the modified International Tumor Budding Consensus Conference (ITBCC) criteria. 147 NAT-treated iCCA cases were included in this study. In biopsy specimens obtained before NAT, the TB-positive subgroup had lower overall survival (OS) in univariate analysis (P = 0.010). In resection specimens obtained after NAT, the TB-positive subgroup had reduced OS (P = 0.002) and recurrence-free survival (RFS) (P = 0.013) in univariate analysis. In multivariate analysis including TNM stage, lymphovascular invasion and perineural invasion, TB-positive in post-NAT resection was also found as an independent prognostic factor for both OS and RFS (OS, HR, 3.005; 95% CI, 1.333-6.775, P = 0.008; RFS, HR, 1.748; 95% CI, 1.085-2.816, P = 0.022). In conclusion, assessing the presence of TB by modified ITBCC criteria provides robust prognostic information in the NAT setting of iCCA patients and can be considered to be included in routine pathological reporting.
PURPOSE:To obtain a modified powder having suppressed light scattering on the surface and useful as a cosmetic additive to give a highly durable cosmetic by coating a powder with a film of a polymer of a methylhydrogen polysiloxane and trimethylsiloxy silicate. CONSTITUTION:This modified powder is produced by coating a powder such as cellulose powder and pigment powder with (A) a methylhydrogen polysiloxane [e.g. a compound of the formula (m=10; n=40; 50cs) and (B) trimethylsiloxy silicate and heat-treating the product at 70-200 deg.C for 0.5-24hr. The sum of A and B is 12-80 pts.wt. based on 100 pts.wt. of the powder. A dry method to mix both components with a Henschel mixer, etc., is most inexpensive and preferable for the coating of the powder with the components A and B. The weight ratio of A:B is preferably 2:98 to 98:2.
PCT No. PCT/GB94/01613 Sec. 371 Date Mar. 6, 1996 Sec. 102(e) Date Mar. 6, 1996 PCT Filed Jul. 27, 1994 PCT Pub. No. WO95/04704 PCT Pub. Date Feb. 16, 1995A process for preparing zinc oxide comprises introducing, into an atmosphere, an aqueous solution of a zinc salt that is thermally decomposable to zinc oxide, the atmosphere having a temperature sufficient to decompose the salt to the oxide, and recovering zinc oxide. The zinc oxide so-prepared is in the form of discrete particles which can have an average particle size of 0.08  mu m or less in diameter and a surface area of at least 12.5 m2/g and which is also free of zinc metal. The small particle size zinc oxide is particularly useful as a UV absorbing/scattering additive.
The invention relates to a purple-through cypress root medicinal composition, a premix and a batch for improving the immunity of livestock and poultry organisms and preventing diseases, and belongs to the field of veterinary medicaments and premixes. The pharmaceutical composition comprises the following components in parts by weight: 30-80 parts of traditional Chinese medicine components, 1-20 parts of vitamin C and 5-50 parts of citric acid. The pharmaceutical composition can be prepared into powder to be directly added into feed for preparing feed for promoting growth, such as: premix, batch, etc.; or further processing into granule, tablet, etc. Clinical verification shows that the purple-through cypress root medicinal composition has the effects of strengthening body resistance to eliminate pathogenic factors, strengthening body resistance and cultivating vigor, and is suitable for improving the immunity of livestock and poultry and preventing diseases. The purple-through cypress root medicinal composition has the characteristics of scientific formula, exact curative effect, high safety, stable preparation, controllable quality, simple preparation process, suitability for industrial production and the like.
The purposes of this research were to investigate the effect of age and chronic neck pain on cervical proprioception, the change of ultrasonographic (USD) patterns in deep neck muscle and superficial neck muscles. The hypotheses of this research included: 1) the alteration of neck proprioception is determined predominantly by the changed activation deep neck muscles and superficial neck muscles. 2) Age factor contributes to the alteration of cervicocephalic sensibility, USD pattern of deep and superficial muscles. 3) Chronic pain contributes to the alteration of cervicocephalic sensibility, USD pattern of deep and superficial muscles.

Neck proprioception is measured by an ultrasound-based coordinate measuring system (CMS 70P, Zebris, Germany) by asking the subjects to performed head repositioning to the neutral head position or to a target position in three cardinal plane. These repositioning error expressed in root mean square errors could represent the craniocervical kinesthetic sensibility. The change of muscle thickness (mm) of the superficial (Trapezium, Splenius) and deep (semispinalis cervicis and multifidus) dorsal neck muscle is measured by a real-time ultrasonographic scanner (HDI 5000, ATL Ultrasound, USA). Image is obtained for each cervical level, and the thickness of the muscle is identified manually using a custom-written C++ computer graphic program. The measurements of pain intensity and pain frequency are modified from the symptoms questionnaire to indicate the intensity, location, frequency and duration of pain and disability of the subjects. The age and pain effects for each independent variables measured in patients with chronic neck pain (pain: intensity, location, frequency, and duration, NDI), will be tested with the General Linear Model (GLM; age and pain factors). The confounding factors such as gender, range of motion, body height and weight are controlled in the regression model.
This group consists of 22 subjects who have chronic pain conditions but were not on an opioid regimen over the last 3 months. Subjects were randomized to receive a ketamine treatment during the study. They were given an intravenous infusion of ketamine (0.05mg/kg) diluted in 50 ml normal saline over 30 minutes.
Disclosed is the Chinese traditional medicine compound for treating acid vomiting and stomach coldness which belongs to the Chinese patent medicine technical field. The invention specifically relates to the Chinese patent medicine in treatment of acid stomach, stomachache and gastrectasia, rancid eructation, increased paining when meeting coldness, hot drink favoring, or faint stomachache and thin excrement. After thirty years of examination to the Chinese medicine market, the inventor finds that the number of the medicine sold in the market for treating the acid vomiting and stomach coldness is little, the curative effect is low, and the technique lags behind the invention. The effect can be showed immediately after taking the medicine of the invention, the effect acts within one day, the curative effect endures long and will not easily reoccur. The inventor considers the invention as the world leading medicine in the same category of Chinese traditional medicine, and expects the common recognition can be achieved early. The invention comprises the prepared liquorice, the villous amomum, the endothelium corneum gigeriae, the sojutsu var, the lesser galangal, the combined spicebush root, the best-quality cinnamon, the weeping forsythia capsule and the fructus galangae. The medicine is safe, the cost is low, the drug sources are broad and the production art is simple.
BACKGROUND: Over the years, with the improvement of diagnostic and therapeutic capabilities for hip joint diseases and the advancements in surgical technology, hip arthroscopy has been extensively used. At present, there is ongoing controversy among scholars about whether it is necessary to close the joint capsule after hip arthroscopy. In addition, the clinical effect of repairing the hip joint capsule after hip arthroscopy remains uncertain.
PURPOSE: To evaluate the effect of our modified shoelace suture technique on postoperative hip function and to investigate whether complete closure of the hip capsule is reliable and safe.
STUDY DESIGN: Retrospective study; Levels of evidence: III.
METHODS: A retrospective review was conducted on patients undergoing hip arthroscopy by a solitary high-volume hip arthroscopic surgeon. The patients were categorized into two groups. The first group consisted of patients who underwent the modified shoelace continuous capsular closure technique. The other group consisted of those who did not receive capsular closure after hip arthroscopy. Patient-reported outcomes including modified Harris Hip Score (mHHS), Hip Outcome Score of Activities of Daily Living (HOS-ADL), Hip Outcome Score Sport-Specific Subscale (HOS-SSS), and visual analogue scale (VAS) were obtained at a minimum of 12 months. Any complications during follow-up were identified and recorded.
RESULTS: A total of 100 patients were followed up for 12-15 months, with an average of (12.3 ± 5.3) months in the study. There were 50 patients in the shoelace capsular closure group (CC group) and 50 patients in the non-capsular closure group (NC group). The surgical time in the suture group was significantly longer than that in the non-suture group. However, there was no statistically significant disparity in the length of hospital stay between the two groups. The mHHS, HOS-SSS, HOS-ADL, and VAS of the CC and NC group were significantly improved compared to preoperative scores at 6 and 12 postoperative months (P < 0.001). Compared with the NC group, the CC group showed a significant improvement in the mHHS, HOS-SSS, HOS-ADL, and VAS at 6 postoperative months (t = 4.885, P<0.001; t = 5.984, P<0.001; t = 4.279, P<0.001; t = 3.875, P<0.001). The mHHS, HOS-SSS, HOS-ADL, and VAS at 12 postoperative months were significantly better in the CC group than in the NC group (t = 5.165, P<0.001; t = 3.697, P<0.001; t = 4.840, P<0.001; t = 3.579, P = 0.001). There were no serious complications during the perioperative period.
CONCLUSION: The modified shoelace continuous capsular closure technique is a reliable and secure method that can be used as an alternative to the conventional capsular closure. It is recommended to perform routine intraoperative repair of the articular capsule at the end of hip arthroscopy, as this has a positive influences on the functional results at short-term follow-up.
Participants will receive a fixed dose of daratumumab as 1800 milligram (mg) subcutaneously (Dara SC) co-formulated with recombinant human hyaluronidase (rHuPH20) 2000 Unit per milliliter (U/mL), once weekly in Cycle 1 and 2, every 2 weeks in Cycle 3 to 6, every 4 weeks in Cycle 7 and thereafter until disease progression, unacceptable toxicity or the end of study. The duration for each cycle is 4 weeks.
1. Technical Result Widening of assortment of antitumor means. 2. Essence Compound of the formula (1) wherein R and R1 are indicated in the description; or a pharmaceutically acceptable salt thereof. Method for its production and use thereof for the treatment of cell proliferative disorders caused by activity changes in cell dependent kinase. 3. Field of Application Pharmacology, medicine.
A construction method for and an application of a nucleic acid multimerization-mediated multivalent protein drug and vaccine. Specifically provided is a multimeric complex based on complementary nucleic acid backbones. The complex is a multimer formed by complexing of 3-6 monomers having complementary nucleic acid backbones, wherein each monomer is a polypeptide having a nucleic acid single strand. In the multimer, the nucleic acid single strand of each monomer and the nucleic acid single strands of the other two monomers form double strands by means of base complementation, so as to form complementary nucleic acid backbone structures. Also provided are a pharmaceutical composition containing the multimeric complex, a nucleic acid sequence library used for constructing the multimeric complex, and a method for optimizing complementary nucleic acid backbones. By means of the method, off-the-shelf short-acting protein drugs or antigens can be used to complete multivalent formation of protein drugs or antigens without the need of reconstruction of fusion proteins or chemical modification and cross-linking, thereby improving their half-life and activity, and/or immunogenicity.
PURPOSE OF REVIEW: The purpose of this study was to conduct a scoping review to map intervention, sample, and physiologic measurement characteristics of lifestyle interventions for gestational diabetes mellitus (GDM) prevention.
RECENT FINDINGS: A total of 19 studies met selection criteria from 405 articles screened (PubMed, Web of Science). No studies were US-based (47% multi-site), and all were delivered in clinical settings. The most targeted nutrition components were low carbohydrate intake (sugar rich foods/added sugars, low glycemic index), low fat intake (mainly low-fat meat, dairy, and saturated fat), and increased fruits and vegetables. Many studies promoted 150 min/week moderate-intensity physical activity. Only two studies provided supervised physical activity sessions. Dietitians and nurses were the most common implementers. Samples were characterized as adults with obesity (mean age 31 yr, BMI 31 kg/m2). Asian populations were predominantly studied. Four studies used theoretical frameworks (75% of which used Social Cognitive Theory). GDM diagnostic criteria set forth by the American Diabetes Association were the most widely used. Insulin sensitivity was commonly assessed via fasting indices. There was a lack of multi-disciplinary, multi-level, and theory-based lifestyle interventions for reducing GDM risk. Addressing these gaps and prioritizing high-risk populations in the US with measurement of traditional and novel biomarkers will advance the field.
Food impaction is a common complication after implant-supported restorations. Several studies have reported that more than 40%-66.9% of patients feel food impaction between the implant restoration and adjacent natural teeth. The most common cause of food impaction after implant restoration is the proximal contact loss(PCL), which has been reported to occur in 34% to 65% of cases. The location of PCL creates discomfort and leads to gingival inflammation and even peri-implant bone resorption, which ultimately leads to loosening of the implant. In our long-term clinical observation, not all final restorations suffer from PCL. The occurrence of PCL may be related to a number of factors such as age, gender, functional time, and so on. However, the literature addressing this issue is still limited. In this study, we collected and analysed the review results of selected patients who underwent implant-supported restorations in the First Hospital of Nanjing, China, to investigate the incidence of PCL between the implant restorations and the adjacent teeth adjacent , and the factors influencing it. Our findings may provide better insights for treatment planning and prevention of PCL.
One tablet daily for the double-blind treatment period. 10 mg Atorvastatin titrating to 20mg.
The participant will follow a ketogenic diet for 72 hrs prior to the experiment and consume a ketone supplement 60 minutes prior to the experiment. They will document their diet and be tested for ketone level immediately prior to the experiment.
The invention provides a LM609 grafted antibody comprising one or more CDRs having at least one amino acid substitution, where the LM609 grafted antibody has α v β 3  binding activity. Nucleic acids encoding LM609 grafted heavy and light chains are additionally provided. Functional fragments of such encoding nucleic acids are similarly provided. The invention also provides a method of inhibiting a function of α v β 3 . The method consists of contacting α v β 3  with a LM609 grafted antibody or functional fragments thereof under conditions which allow binding to α v β 3 . Finally, the invention provides for a method of treating an α v β 3 -mediated disease. The method consists of administering an effective amount a LM609 grafted antibody or functional fragment thereof under conditions which allow binding to α v β 3 .
BACKGROUND: Intravascular injection represents the most severe complication in fat transplantation procedures. Currently, the prognosis for patients who suffer from blindness due to fat transplantation-induced ocular vascular occlusion is far from optimistic.
OBJECTIVES: The aim of this study was to explore and evaluate the efficacy and safety of arterial thrombolysis in the treatment of ocular vascular occlusion caused by fat transplantation.
METHODS: We analyzed the data of 12 patients who underwent intraarterial thrombolysis and conservative treatments for facial autologous fat grafting-associated ocular vascular occlusion. Among the cases, there were 6 instances of ophthalmic artery embolism and 6 cases of central retinal artery occlusion. All patients suffered with sudden blindness, sometimes accompanied by eye pain, ptosis, strabismus, skin necrosis at the injection site, or cerebral microinfarction. They received symptomatic conservative treatments and intraarterial thrombolysis, encompassing mechanical vessel recanalization, vessel dilation, and dissolution of thrombus constituents.
RESULTS: Following intraarterial thrombolysis, a noteworthy improvement in the blood flow of both the main trunk and peripheral branches of the ophthalmic artery was observed in the majority of patients when contrasted with their pretreatment status. One patient experienced a headache intraoperatively, while no significant discomfort was reported by the remaining patients. After conservative treatments and intraarterial thrombolysis, all patients experienced improvement in ocular symptoms, skin necrosis, and cerebral infarction. Three patients demonstrated improvement in visual acuity. These patients had surpassed the recommended time window for treatment, yet the occlusion of the ophthalmic artery was not complete.
CONCLUSIONS: Intraarterial thrombolysis combined with conservative treatments achieves early perfusion and is expected to promote visual recovery. Hospitals that possess the necessary treatment capabilities are encouraged to establish this therapeutic pathway.
An increasing number of children with complex chronic conditions (CCCs) who have intractable illnesses or multi-organ dysfunction are exposed to daily polypharmacy. Parents of children with polypharmacy often administer 5 or more medications each day, sometimes for months, including high-risk medications prescribed by many different specialists in multiple settings of care. While medications can be life-saving, polypharmacy increases the risk of additive adverse effects, drug-drug interactions, and can lead to serious adverse drug events (ADEs). Pediatric ADEs result in over 4.3 million estimated ambulatory visits annually, including \>150,000 pediatric emergency room visits. Despite the risks associated with polypharmacy, little is known about how polypharmacy escalates and how polypharmacy should be managed. To enable children to thrive at home using medications while minimizing unwanted symptoms, this proposal aims to implement a prospective, parent-reported symptom assessment system to guide and monitor pharmaceutical care for high-risk children. Strategies to improve recognition of problematic symptoms will have a substantial impact on the health of children.
Besides Conventional Physical Therapy, Mulligan Mobilizations will be provided in this group. It consist of Extension SNAGS in prone, and Lumbar flexion SNAGS in sitting. The techniques will be applied in 3 sets with 10 repetitions and 60 seconds rest between sets.
Immediate postcraniotomy headache frequently occurs within the first 48 h after surgery. The mechanisms underlying immediate postcraniotomy headache are not yet fully understood, and effective treatments are not yet established. This study aimed to identify the factors associated with immediate postcraniotomy headache in patients who underwent clipping surgery with frontotemporal craniotomy and to examine the effects of these factors on postcraniotomy headache. A total of 51 patients were included in this study. Immediate postcraniotomy headache was defined as pain with numerical rating scale score ≥4 on postoperative day 7. Sixteen patients (31.4%) had immediate postcraniotomy headache. The headache-positive group had a higher incidence of preoperative analgesic use (50.0% vs. 5.7%, respectively, p < 0.001), increased temporal muscle swelling ratio (137.0%±30.2% vs. 112.5%±30.5%, respectively, p = 0.01), and higher postoperative analgesic use (12.9±5.8 vs. 6.7±5.2, respectively, p < 0.001) than the headache-negative group. The risk factors independently associated with immediate postcraniotomy headache were preoperative analgesic use and temporal muscle swelling by >115.15% compared with the contralateral side in the receiver operating characteristic analysis. Postcraniotomy headache was significantly more common in patients with preoperative analgesic use and temporal muscle swelling than in those without (p < 0.001 and p = 0.002, respectively). Altogether, patients with immediate postcraniotomy headache had greater preoperative analgesic use, greater temporal muscle swelling ratio, and higher postoperative analgesic use than those without. Thus, temporal muscle swelling is a key response to immediate postcraniotomy headache.
The present invention relates to a medicine and a preparation method thereof, namely a Mongolian medicine Baolier which has obvious therapeutic effect on hyperlipemia and a preparation process thereof. The hyperlipemia is an important factor which is the initiation of cardio-cerebral diseases, such as the thrombosis, the arteriosclerosis, the coronary disease, etc. Oral administration medicines which has the advantages of convenient administration, small toxicity and side effects and obvious curative effect are deficient at present. On the basis of Mongolian medicine prescriptions, the present invention adopts a modern technology, axillary choerospondias fruit, red sage roots, elecampane, nutmeg, gardenia, sandalwood, milkvetch roots, dalbergia wood, safflower, radices pseudoginseng, bezoar, musk, etc. are used as main raw materials for preparing the Mongolian medicine Baolier. A great number of experiments and clinical applications show that the Baolie has the efficacy on promoting flow of qi and blood circulation, absorbing clots and relieving stagnancy, and ascending the clear and descending the turbid; the Baolie can reduce blood fat, total cholesterol and triglyceride, has relatively obvious function of enhancing the contents of high density lipoprotein cholesterol, and has exact therapeutic effect on hyperlipemia.
People between the ages of 50-75 with no previous diagnosis of colon cancer, who have been screened for colon cancer (or discussed screening for colon cancer) in the past 2 years, or who had first colon cancer screening in past 2 years. These people will see items only pertaining to colon cancer screening.
Participants will receive the investigator's choice of gemcitabine or bendamustine. The regimen to be used after randomization must be selected by the investigator prior to randomization. Gemcitabine will be administered intravenously (IV) on days 1, 8, and 15 of each 28-day cycle for up to 6 cycles. Bendamustine will be administered IV on days 1 and 2 of each 21-day cycle for up to 6 cycles.