anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Acetaminophen (APAP) overdose is the primary cause of drug‑induced acute liver failure in numerous Western countries. NLR family pyrin domain containing 3 (NLRP3) inflammasome activation serves a pivotal role in the pathogenesis of various forms of acute liver injury. However, the cellular source for NLRP3 induction and its involvement during APAP‑induced hepatotoxicity have not been thoroughly investigated. In the present study, hematoxylin and eosin staining was performed to assess histopathological changes of liver tissue. Immunohistochemistry staining(NLRP3, Caspase‑1, IL‑1β, GSDMD and Caspase‑3), western blotting (NLRP3, Caspase‑1, IL‑1β, GSDMD and Caspase‑3) and RT‑qPCR (NLRP3, Caspase‑1 and IL‑1β) were performed to assess the expression of NLRP3/GSDMD signaling pathway. TUNEL staining was performed to assess apoptosis of liver tissue. The serum expression levels of inflammatory factors (IL‑6, IL‑18, IL‑1β and TNF‑α) were assessed using ELISA and inflammation of liver tissue was assessed using immunohistochemistry (Ly6G and CD68) and RT‑qPCR (TNF‑α, Il‑6, Mcp‑1, Cxcl‑1, Cxcl‑2). A Cell Counting Kit‑8 was performed to assess cell viability and apoptosis. Protein and gene expression were analyzed by western blotting (PCNA, CCND1) and RT‑qPCR (CyclinA2, CyclinD1 and CyclinE1). Through investigation of an APAP‑induced acute liver injury model (AILI), the present study demonstrated that APAP overdose induced activation of NLRP3 and cleavage of gasdermin D (GSDMD) in hepatocytes, both in vivo and in vitro. Additionally, mice with hepatocyte‑specific knockout of Nlrp3 exhibited reduced liver injury and lower mortality following APAP intervention, accompanied by decreased infiltration of inflammatory cells and attenuated inflammatory response. Furthermore, pharmacological blockade of NLRP3/GSDMD signaling using MCC950 or disulfiram significantly ameliorated liver injury and reduced hepatocyte death. Notably, hepatocyte Nlrp3 deficiency promoted liver recovery by enhancing hepatocyte proliferation. Collectively, the present study demonstrated that inhibition of the NLRP3 inflammasome protects against APAP‑induced acute liver injury by reducing hepatocyte pyroptosis and suggests that targeting NLRP3 may hold therapeutic potential for treating AILI.
Stereotactic Body Radiation Therapy (SBRT) is a relatively new radiation technique in which a few very high doses of radiation are delivered to small, well-defined tumors. It has been used effectively in other cancers like lung and liver. The goal is to deliver a radiation dose that is high enough to kill the cancer while limiting radiation to surrounding healthy organs. The daily dose of radiation is 2-3 times greater than conventional radiotherapy, but it is given for only 5 days over a 2 week period. Conventional radiotherapy is given over 6-7 weeks. The chemotherapy drug, cisplatin is used as a radiation sensitizer and will be given before each of the 5 radiation treatments.
A new and exciting way of delivering mouth wash to the mouth. The mouth wash is put into gum. The gum is chewed. The mouth wash is then delivered to the mouth through the gum as the gum is chewed. The gum has mouth wash in it. The mouth wash then comes out of the gum that is being chewed. The mouth wash then washes the mouth for dental hygiene.
The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which comprise of bioactive agent and an organocobalt complex. The bioactive agent is covalently bonded directly or indirectly to the cobalt atom of the organocobalt complex. The bioactive agent is released from the bioconjugate by the cleavage of the covalent bond between the bioactive agent and the cobalt atom in the organocobalt complex. The cleavage may occur as a result of normal displacement by cellular nucleophiles or enzymatic action, but is preferably caused to occur selectively at a predetermined release site by application of an external signal. The external signal may be light or photoexcitation, i.e. photolysis, or it may be ultrasound, i.e. sonolysis. Further, if the photolysis takes places in the presence of a magnetic field surrounding the release site, the release of the bioactive agent into surrounding healthy tissue is minimized.
The invention provides Maca compositions, and a compound preparation and an application thereof. The invention provides the Maca zinc composition with a Maca powder and nutrition zinc as active ingredients. The invention provides the Maca-Liuweidihuang pill composition with a Maca powder and a Liuweidihuang pill extract as active ingredients. The invention provides the Maca-wolfberry-radix astragali composition with a Maca powder, radix astragali, wolfberry and soybean isoflavone as active ingredients. The invention provides the Maca-radix puerariae composition with a Maca powder, radix puerariae and raspberry as active ingredients. The series of compositions added with edible auxiliary materials can be made into tablets (pressed cadies) and capsules. The compositions are in matched combination according to respective functional characteristics, and have a series of functions of tonifying kidney, tonifying yang, relieving physical fatigue, treating prostatitis, treating climacteric syndromes and resisting depression.
PURPOSE:To collect the accurate measurement data and to quickly totalize these data by comparing the present measurement value with the past one when the former value is obtained to decide the propriety of the measurement and immediately instructing a second measurement when a first measurement is not satisfactory. CONSTITUTION:The identification information which specifies an individual and the past measurement data are transferred to a semiconductor card storage means 2 by a data collection/distribution device 1. Then a person to be examined puts the means 2 into an IC cardreader/writer device 8 of measuring instruments 3-7 respectively for the measurement of each measurement item. Thus, the device 8 compares the present measurement value with the past one to decide whether the present measurement value is kept within a prescribed range of the predictive data or not. If so, the present measurement value is decided normal and recorded into the means 2. If not, the present measurement value is decided defective and the second measurement is instructed. Thus the trouble some procedures can be eliminated for the second examination.
There is evidence that positive emotion stimuli can lead to improved performance in attention tasks and the investigators aim to understand the benefits of using this principle in cognitive and upper-limb motor rehabilitation following stroke. For this purpose, the investigators developed a VR attention task in which the user has to find a target image within a variable number of distractors by controlling a virtual arm. In some levels of the task the target has to be memorized, hence training both attention and memory. The target stimuli are positive images based on the individual preferences of each user.

40 participants within the first 6 months after stroke will be randomly allocated to one of two groups: 1) VR motor-cognitive task or 2) standard rehabilitation. The VR motor-cognitive task group will use the above described virtual task customized to each user in terms of the positive content. This also includes selected music that will be introduced in half of the sessions. The standard rehabilitation group will undergo conventional motor and cognitive rehabilitation. The intervention consists of 12 sessions of 45 minutes administered within a 4-6 weeks period. The participants will be evaluated using a number motor and cognitive assessment scales at baseline, end of the intervention and a 1-month follow-up.
Each participant will be assigned in one of three groups. In each group there will be 15 participants. Different treatment protocols will be carried in each group as follows: group one (scaling and root planing), group two (scaling and root planing + LASER), group three (scaling and root planing + hyaluronic acid). Under local anesthesia we will perform scaling and root planing of the teeth in two sessions. The procedure be made with the use of ultrasonic (PiezoLED Scaler, KaVo, Biberach, DE) and hand instruments (Gracey, Hu Friedy, Chicago, IL, USA). In group one, only scaling and root planning (SRP) will be made. In group two, the use of a diode laser (Dentsply Sirona - SIROLaser Blue) will be added to the therapy. In group three, after the performance of SRP, a gel containing hyaluronic acid (Regedent, HyaDENT Cross linked hyaluronic acid gel) will be applied intrasulcular.
The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally directed to microparticles containing entities therein, where the entities contain an agent that can be released from the microparticles, e.g., via diffusion. In some cases, the agent may be released from the microparticles without disruption of the microparticles. The entities may be, for instance, polymeric particles, hydrogel particles, droplets of fluid, etc. The entities may be contained within a fluid that is, in turn, encapsulated within the microparticle. The agent may be released from the entity into the fluid, and then from the fluid through the microparticle. In such fashion, the release of agent from the microparticle may be controlled, e.g., over relatively long time scales. Other embodiments of the present invention are generally directed to methods of making such microparticles, methods of using such microparticles, microfluidic devices for making such microparticles, and the like.
PURPOSE: Provided is novel constructs and vectors for the targeted and inducible expression of genes. In particular novel hybridpromoters and their use for the expression of genes in hepatic cells, in vitro or in vivo. CONSTITUTION: A recombination vector, arranged under the regulation of promoter, comprises an expression cassette constituting nucleic acids coding a desirable protein and is enable to express genes inducibly by fibrate and selectively in a hepatic cell. A promoter comprises a regulator of human Apolipo protein AII(apoAII) gene. In particular, 3'end and 5' end thereof are located at between +5 and +35, preferably, +10 and +30, and between -950 and -905, preferably, -925 and -910 of apoAII gene residue respectively. The favorable recombination vector is a virus vector, especially, induced from adenovirus vector, comprising an expression cassette which is inserted into E4 region of the genome as a substitute for a deletion.
This phase II clinical trial will utilize intensity modulated whole brain radiation therapy in order to deliver a smaller, yet effective dose for subclinical disease while giving a higher dose to gross disease for patients with more than one brain metastasis. In this study, a dose of 30 Gray (Gy) will be prescribed to subclinical sites and 60 or 45 Gy to visible brain metastases.

There is evidence from previous studies (including Radiation Therapy Oncology Group (RTOG) 0933) that hippocampal avoidance during whole brain radiotherapy using IMRT may decrease toxicity in the form of memory loss. Patients who had brain metastases within the region of hippocampal avoidance were not eligible for enrollment on RTOG 0933. In contrast, this study will include this group of patients since IMRT will be used to not only deliver higher doses to visible brain metastases even though they are located within the hippocampal avoidance region, but also to avoid the hippocampus itself. This approach may help to preserve memory function. Additionally, while temporary (and sometimes permanent) alopecia results from conventional whole brain radiation, IMRT spares the skin and possibly decreases the rate of hair loss. Dose to the scalp will be limited to as low as possible in order to decrease the risk of permanent alopecia in this study.
PURPOSE: To obtain a gel type composition for cleansing having both excellent cleaning effect and improved safety, comprising a gel structure prepared from a nonionic surfactant, a hydroxyl group-containing water-soluble compound, a liquid oil and water. CONSTITUTION: This gel type composition for cleansing is obtained by mixing a nonionic surfactant such as a polyoxyethylene alkyl ether with a hydroxyl group-containing water-soluble compound such as glycerol, a liquid oil such as liquid paraffin and water in a blending composition to form a gel. A polyoxyethylene sorbitan fatty acid ester and a sorbitan fatty acid ester are preferable as the nonionic surfactant. A polyhydric alcohol and an adduct of ethylene oxide to a saccharide derivative are preferable as the water-soluble compound. Glycerol tri-2-ethylhexanoate and methylphenylpolysiloxane are preferable as the liquid oil. The composition is extremely spreadable, has no greasiness, refreshment and an excellent feeling in use and improved in stability, cleaning properties and water cleaning properties.
Pharmaceutical preparations having inhibiting properties on the central nervous system comprise g -amino-b -(3,4-dichlorophenyl)-butyric acid, or a salt thereof in admixture or conjunction with a carrier.  Conventional carriers may be used together with preservatives, stabilisers, melting agents, emulsifiers, solution promoters, buffers, and/or salts for regulating osmotic pressure.  The preparations may be administered orally, rectally, or parenterally, for example, in the form of tablets, drag<\>aees, capsules, solutions, suspensions, or emulsions, optionally with other therapeutically-useful substances.  The salts may be formed with therapeutically-useful bases e.g. organic amines, metals e.g. alkali or alkaline earth metals.  Acid addition salts may be formed with inorganic or organic acids, including several amino acids.
Angiography is the current standard method to guide PCI strategy in clinical practice. However, angiography has a number of well-described limitations, primarily through only providing an assessment of luminal dimensions without delineation of the burden of atheroma-tous disease. Angiography also provides suboptimal assessment of post PCI complications such as stent underexpansion or malapposi-tion, residual dissections or thrombus, and tissue prolapse. These limi-tations may be overcome in part by intravascular imaging (IVI), which allows tomographic, cross-sectional imaging of the vessel wall. Meta-analyses of randomized and registry studies of IVI-guided vs. angi-ography-guided PCI have suggested that IVI-guidance may improve clinical outcome following PCI.

Optical coherence tomography (OCT) provides high-resolution (10-20 μm) cross-sectional images of plaque microarchitecture, stent place-ment and size and strut coverage. Recently the MLD-MAX algorithm was developed to guide and stand-ardize coronary stent implantation based on sizing of the vessel at the proximal and distal reference using the EEL.
Kidney fibrosis is a common fate of chronic kidney diseases (CKDs), eventually leading to renal dysfunction. Yet, no effective treatment for this pathological process has been achieved. During the bioassay-guided chemical investigation of the medicinal plant Wikstroemia chamaedaphne, a daphne diterpenoid, daphnepedunin A (DA), is characterized as a promising anti-renal fibrotic lead. DA shows significant anti-kidney fibrosis effects in cultured renal fibroblasts and unilateral ureteral obstructed mice, being more potent than the clinical trial drug pirfenidone. Leveraging the thermal proteome profiling strategy, cell division cycle 42 (Cdc42) is identified as the direct target of DA. Mechanistically, DA targets to reduce Cdc42 activity and down-regulates its downstream phospho-protein kinase Cζ(p-PKCζ)/phospho-glycogen synthase kinase-3β (p-GSK-3β), thereby promoting β-catenin Ser33/37/Thr41 phosphorylation and ubiquitin-dependent proteolysis to block classical pro-fibrotic β-catenin signaling. These findings suggest that Cdc42 is a promising therapeutic target for kidney fibrosis, and highlight DA as a potent Cdc42 inhibitor for combating CKDs.
The invention relates to a traditional Chinese medicine, in particular to a medicine for treating liver diseases. The medicine is prepared from, by weight, the medicinal effective components of rubus crataegifolius and lantern plant calyx bulk drugs. The medicine can treat indications of hepatitis A, hepatitis B, hepatitis C, the fatty liver, cirrhosis and early-stage liver ascites. Each treatment course lasts for one month, and usually the liver diseases can be cured within 2-8 months. The medicine is a secret prescription handed down from ancestors, and is reliable in treatment effect. The formulation is simple, and the raw materials are cheap. The medicine is taken by 165 patients, and the total effective rate is 100% through cumulative sorting statistics.
Patients were orally received hydronidone capsules,3 capsules each time, t.i.d. for 52 weeks.
The invention belongs to traditional Chinese medicine preparations, and provides a convenient and effective method to treat laryngocarcinoma through traditional Chinese medicine. Laryngocarcinoma usually brings endless pains to a patient, even takes away life of the patient. In western medicine, an operation is usually performed to eliminate laryngocarcinoma focus, in this situation, the patient usually suffers from larger wounds and expensive medical fees which the patient usually cannot afford. After groping and practicing for many years, a pill for treating laryngocarcinoma is developed, and the pill is like a gospel for the patient with laryngocarcinoma. The formula comprises 9 g of scorpion and centipede respectively, 30 gecko (using 60 g of japonica rice and frying the japonica rice together with the gecko till the color gets dry and yellowish, leaving the japonica rice), 30 g of borax, 15 g of alumen, bombyx batryticatus, and blackberry lily respectively, 30 g of Cremastra appendiculata and acacia catechu respectively, and 9 g of glycyrrhiza uralensis. Meanwhile, 30 g of asparagus and 15-30 g of garlic juice are additionally added. In this way, a pill is finally prepared. A usage method comprises the steps of porphyrizing the materials into fine powder, using 30 g of asparagus to make decoction, adding 15-30 g of garlic juice, blending the mixture and rubbing the mixture with hands into the pill of which the size is as big as a phoenix tree seed, airing the pill and storing the pill into a flask for standby application, and making the flask airtight. When using the pill, the patient needs to take 3 granules of the pill, keeps three granules in mouth at one time and swallows the granules slowly, and every day the patient needs to keeps the granules in mouth and swallow the granules for three times. In addition, the pill relives internal heat and softens hard mass, eliminates diseases and prevents cancer, proves success in every test, and has definite effects.
31-year-old woman. Diagnosis of ulcerative proctitis in February/2022. Calprotectin 1832 μg/g. Colonoscopy: erythematous, friable and erosive mucosa up to 10 cm from the anal margin. Pathology: compatible with ulcerative colitis with moderate activity. Start of oral mesalazine (3 gr/24 h granules) and topical (1 gr/24 h suppository). After three months, she achieved clinical remission. Calprotectin 57 μg/g. Two months later, she consulted for solid dysphagia, loss of 10 kg, and low-grade fever for a month. Fifteen days before, she went to an emergency room where Prednisone 50 mg/24 h was started. On the day of the assessment, she was receiving 30 mg with no improvement. The next day, gastroscopy showed 6-12 mm esophageal ulcers with non-confluent shallow geographic borders, biopsies were taken. Viral serologies and HLA B51 were requested. Given the severity of the symptoms, empirical treatment was started with Valaciclovir 1 g/12 h. Serologies: IgG for Ebstein Barr virus, cytomegalovirus and herpes virus with negative IgM. Cytomegalovirus viral load: <30 IU/ml. Pathology: acute extensively ulcerated esophagitis, inflammatory infiltrate and some eosinophils with negative histochemical staining for fungi, cytomegalovirus and herpes virus I and II. HLA B51 was negative. Valaciclovir and mesalazine are discontinued after seven days given the known relationship of the latter with low-grade fever and, exceptionally, with esophageal pathology. Three days later, the patient reported clear improvement in dysphagia from the day the mesalazine was discontinued. After eight months, she was still asymptomatic. Upon resolution of the symptoms, control gastroscopy was not performed, and mesalazine has not been reintroduced due to its probable causal association. Mesalazine has an excellent safety profile. Adverse effects include fever, headache, diarrhea and.
Patients with cancer experience higher rates of preventable harm from hospital-acquired bloodstream infections (haBSIs) and central-line-associated bloodstream infections (CLABSIs) compared with the general hospital population. The prevention of haBSIs and CLABSIs in patients with cancer is an urgent priority, and requires standardized surveillance and reporting efforts. The application of haBSI and CLABSI definitions, classification systems and surveillance strategies for patients with cancer is complex, and there is wide variation in clinical practice. Existing systems were not designed explicitly for patients with cancer, and have different strengths and weaknesses in the cancer setting. For these reasons, epidemiological estimates of haBSIs and CLABSIs in patients with cancer also require careful interpretation. This complexity can be a barrier to identifying appropriate targets for intervention and reducing preventable harm. This review provides an overview of key concepts and challenges in haBSI surveillance and prevention specific to patients with cancer. In addition, this review summarizes the strengths and weaknesses of commonly used surveillance definitions and denominators in the setting of cancer care; existing surveillance practice; epidemiology of haBSIs and CLABSIs; prevention strategies; and current knowledge gaps. A global collaborative effort to harmonize the surveillance of hospital-acquired infections in patients with cancer would be invaluable to improve the accuracy and utility of existing data, advance efforts to prevent hospital-acquired infections, and improve patient safety.
Systems and methods for increasing thermometric reliability are provided. In one embodiment, a system includes a temperature module, an analysis module, and a recommendation module. The temperature module is configured to receive an inquiry from the user about a current measured temperature. The current measured temperature is received from a thermometer. The inquiry indicates that the user doubts the current measured temperature. The analysis module is configured to generate a query based on the inquiry and the current measured temperature. The analysis module is also configured to receive an answer in response to the query. The analysis module is further configured to analyze the current measured temperature in an analysis of historical data. The recommendation module is configured to generate a recommendation associated with the inquiry based on the answer and the analysis.