anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
NEW MATERIAL:The monomer containing 5-aminosalicylic acid group and expressed by formula I [R1 is H or alkyl; R2 is group of formula ll (X is halogen; n is 1-5) or formula III (R3 is H or lower alkyl)]. EXAMPLE:5-(Methacryloyl)amidosalicylic acid. USE:Useful as a remedy for inflammatory intestinal diseases. It can be used e.g. for the remedy of inflammatory intestinal diseases such as ulcerative colitis and Crohn's disease. It has sustained-release action and is free from side effect. It can be administered by oral administration. PREPARATION:The objective compound of formula I can be produced according to the reaction formula by reacting 1-3 pts. of the compound of formula IV or formula V with 1 pt. of 5-aminosalicylic acid or 5-aminosalicylic acid ester in an organic solvent at room temperature to 150 deg.C. The compound of formula I can be polymerized in the form of a homopolymer or a copolymer with other copolymerizable monomers.
FIELD: biotechnology, veterinary science. SUBSTANCE: strain of bacterium Pseudomonas aeruginosa 476 2  is deposited in collection of strains that are pathogens of diseases in fur wild animals of museum of bacterial and viral cultures (NIIPZK) named for V .A. Afanasiev and has registration number 476 2 . Strain relates to serovariant 02/05. Strain is cultured in Marten's broth or synthetic medium at 32 C for 18-20 h at constant shaking. After control of grown culture for toxicogenicity and proteolytic activity bacterial mass is separated and inactivated. Then aluminum hydroxide is added as an adjuvant and packaged. Invention ensures to prevent the concealed loss in fur wild animals reproduction in farms with pyocyanic infection being independently of serological pattern of pathogen. EFFECT: strain indicated above, enhanced effectiveness of vaccine. 3 ex
PURPOSE:To prepare an immobilized glass-coated tube having increased amount of the immobilized component per unit surface area of the carrier, by hydrolyzing a metallic alkoxide under mild condition, and using the produced gel as the carrier for the immobilization of enzyme, etc. CONSTITUTION:The inner surface of a tube is coated with a carrier consisting of a glassy gel of a metallic hydroxide compound and/or its condensate and obtained by the hydrolysis of a metallic alkoxide; and a peptide-containing compound is immobilized to the gel. The metallic alkoxide is e.g. a lower alkoxyl metal compound such as Al(OC3H7)3, NaOCH3, etc., preferably lower alkoxy silane. A solution of the metallic alkoxide is passed through the tube to coat the inner surface of the tube with a thin layer of the metal alkoxide-containing solution. The metallic alkoxide in the thin layer is hydrolyzed to form glassy gel, which is made to react with a silane coupling agent having functiolal group such as amino group, thiol group, epoxy group, etc.; and a peptide-containing compound is immobilized to the reaction product.
Flexibility training of the lower limb muscles. Frequency of intervention: 2-3 times per week. Duration of intervention: 24 weeks.
Participants were asked to practice relaxation tools for 15 minutes a day using the calendar and HeartBot app, and participate in once a week webinar for 30 minutes during the four weeks. UCLA Loneliness scale was recorded prior to the start of the study and at its end after the duration of 4 weeks. The score was reviewed to see the changes in the loneliness scale.
The Geneva Blood Virome Project is a longitudinal observational study. The main objective is to describe the kinetics of the plasmatic viral load of a selection of at least 21 DNA and RNA viruses of the blood virome (Herpesviridae Polyomaviridae, Adenoviridae, Parvoviridae, Anelloviridae, Picornaviridae and Flaviviridae) in allogeneic hematopoietic stem cell transplant recipients, over a period of one year after transplantation. These DNA and RNA viruses can be responsible of acute infections, chronic infections or reactivations after transplantation. Secondary objectives are : 1) to assess the prevalence of DNA and RNA viruses plasmatic detections and co-detections at pre-specified time-points, 2) to assess the cumulative incidence of DNA and RNA viruses plasmatic detection at pre-specified time-points. The population of the study consists in adult patients receiving allogeneic stem cell transplantation at the University Hospitals of Geneva and who are enrolled in an already existing monocentric cohort named "Cohort of infectious disease in hematopoietic stem cell transplant patients" and for which clinical specimens are collected and stored at the time and after transplantation. The investigators plan to include 120 patients whose plasma samples are collected from March 2017 and to systematically use plasma samples collected at 5 pre-specified time points (the day of transplantation, 30 days, 3 months, 6 months, and one year after transplantation) to perform qualitative and quantitative real-time r(RT)-PCR assays for the screening of DNA and RNA viruses. The definitive analysis of results should be done by the end of 2020.
Patients will undergo standard intensity modulated radiation therapy (IMRT) to the pelvic nodes and vaginal cuff (total dose of 45-50.4Gy at 1.8 Gy per fraction) for 5-6 weeks and receive IV Dostarlimab every 3 weeks for 4 cycles followed by 1 dose of 1000mg (C5). Patients will receive a maximum of 5 cycles of Dostarlimab.
AIM: This study aimed to determine the effects of iRoot BP Plus on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in vitro and inflammation-mediated bone resorption in vivo and investigated the underlying molecular mechanisms.
METHODOLOGY: CCK-8 was performed to test cell viability in RANKL-induced RAW 264.7 cells and BMDMs in response to iRoot BP Plus. The effect of iRoot BP Plus on osteoclastogenesis was determined using TRAP staining and phalloidin staining, respectively. Pit formation assay was conducted to measure osteoclast resorptive capacity. Western blot and qPCR were performed to examine osteoclast-related proteins and gene expression, respectively. Western blot was also used to investigate the signalling pathways involved. For in vivo experiments, an LPS-induced mouse calvarial bone resorption model was established to analyse the effect of iRoot BP Plus on bone resorption (n = 6 per group). At 7 days, mouse calvaria were collected and prepared for histological analysis.
RESULTS: We identified that iRoot BP Plus extracts significantly attenuated RANKL-induced osteoclastogenesis, reduced sealing zone formation, restrained osteolytic capacity and decreased osteoclast-specific gene expression (p < .01). Mechanistically, iRoot BP Plus extracts reduced TRAF6 via proteasomal degradation, then suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs), blocked the nuclear translocation of c-Fos and diminished nuclear factor-κB (NF-κB) p65 and NFATc1 accumulation. Consistent with the in vitro results, iRoot BP Plus extracts attenuated osteoclast activity thus protecting against inflammatory bone resorption in vivo (p < .05), which was accompanied by a suppression of TRAF6, c-Fos, NFATc1 and cathepsin K expression.
CONCLUSION: These findings provide valuable insights into the signalling mechanisms underlying nanoparticulate bioceramic putty-mediated bone homeostasis.
Diagnostic Test: Passive Microwave Radiometry The MWR2020 (former RTM-01-RES) device is a unique commercially available CE marked device. The device is already registered in Russia and Kyrgyzstan for diagnostics of different diseases.
A technique for efficiently capturing and retaining patient instructions made by a physician or other medical provider. In a computer-based medical service system, a medical provider utilizes a medical provider portal to interact with the system and a patient utilizes a patient portal to interact with the system. During an appointment utilizing the system, the medical provider inputs medical instructions intended for the patient via the portal. If the patient is utilizing the patient portal during the appointment, a window opens in the patient portal and the instructions input by the medical provider are displayed therein. The instructions are retained and are accessible by the patient whenever the patient utilizes the patient portal. The instructions can have documents associated therewith by the medical services provider which can be attached to the instructions during or after the appointment.
Non-selective close kinetic chain exercises and selective close kinetic chain exercises were applied for 6 weeks in healthy side of the PFPS group. Thigh circumference measurement was performed 5-10 cm above the upper pole of the patella. In addition, evaluation was made with visual analog score (VAS) and Lysholm Knee score (LKS). Vastus medialis obliquus (VMO) and vastus lateralis (VL) muscles of the participants were measured with Shear Wave Elastography 1 day before the therapy and 6 weeks after therapy in hospital.
The present invention includes a urea powder, the particles of which are protected in a dimethicone and silica mixture, prior to being incorporated into anhydrous compositions. The protected urea is capable of imparting a cooling activity to a topical composition. The invention also pertains to topical, cooling compositions containing a protected urea. The use of the protected urea to impart a cooling activity to topical anhydrous compositions is new. Topical, anhydrous compositions comprising the protected urea are also new. Anhydrous compositions containing the protected urea are stable against hydrolysis that might otherwise occur due to the ambient humidity. Disclosed compositions create a clean and fresh feel for a user.
Increasing global temperatures due to climate change have raised serious concerns regarding its potential impact on health outcomes. Pregnant women and their fetuses are among the most vulnerable groups being affected by these dramatic changes resulting in adverse outcomes for both the mother and the developing fetus. Evidence regarding heat-related pregnancy adversities in high-income countries is conclusive, however, such evidence is rare in low- and middle-income countries (LMICs). This review was conducted to bridge the knowledge gap by providing evidence-based insights into the specific repercussions of high heat exposures during pregnancy and its effect on birth outcomes in LMICs. A systematic review was conducted to assess the impact of high environmental or ambient temperatures on pregnancy outcomes (abortion, stillbirth, preterm birth, and low birthweight (LBW)) in LMICs. Electronic searches were conducted on MEDLINE, Embase, CINAHL, Web of Science, and Scopus. Observational studies published between 2010 and 2023 were included in the review. Screening of studies was done using Covidence software, data was extracted on Excel sheets and quality assessment was done using the National Institutes of Health's National Heart, Lung, and Blood Institute tool. We included 11 studies. Four of six studies that included preterm births showed an association between heat and preterm births. Four of five studies reported an association between heat exposure and LBW. Three of four studies on stillbirths showed a significant association between heat exposure and stillbirths. One of the two studies that reported spontaneous abortion revealed a significant association of heat with abortion. Meta-analysis could not be performed due to the lack of homogeneity in defining heat exposure. Amongst the included studies, seven were categorized as "good" and four were categorized as "fair" on methodological quality. This study concluded that ambient temperature and heat exposure during pregnancy can impact birth outcomes such as preterm births, LBWs, abortions, and stillbirths in LMICs. Urgent action is imperative on both national and global scales to facilitate a comprehensive and definitive assessment of heat exposure in LMICs, enabling a deeper understanding of its repercussions on pregnant women. Longitudinal studies are paramount for confirming these associations and devising targeted interventions and strategies aimed at enhancing maternal and child health within LMIC contexts. Registration: PROSPERO ID: CRD42023449173.
All patients underwent preoperative CT scan. Firstly, SurgiCase were used to analyze CT data and design preliminary surgery plans. Secondly, three-dimensions resin skull models were produced by rapid prototyping technology. Model surgeries were performed to determine the location, reduction direction and shift distance of osteotomy. Based on the surgical simulation, the preliminary surgery plans were validated and optimized. Then, the titanium plates and mesh were preshaped on the models. Finally, according to the final surgery plans the operations were performed. The operation time, therapeutic effects and complications were observed. The follow-up periods were 1-12 months.
Participant will perform a 5 min warm-up exercises then do cycling or treadmill running for 20 min at 40%-60% of HRR and then will conclude with 5 min cool down exercises. From week 2 to 6 participants will be instructed to perform a warm up of 5 min, then 4 bouts of 4 min of HIIT will be performed at 80%-95% of HRR separated by 3-min active recovery periods of moderate intensity cycling at 60%-70% of the HRR followed by 5 min cool down exercises. Patients in this group will be provided with a caloric restriction plan by a nutritionist that will be followed throughout the training duration.
The TEA device administers a mild electrical shock through the skin, similar to acupuncture. Stimulation will be performed twice daily, morning and evening for 45 minutes for 8 weeks. Location sets are described in the protocol, which will be shared with results reporting but are not provided here to maintain masking and, therefore, to safeguard scientific integrity.
Cholestyramine for oral suspension, USP, the chloride salt of a basic anion exchange resin, a cholesterol lowering agent, is intended for oral administration. Cholestyramine resin is quite hydrophilic, but insoluble in water. Cholestyramine resin is not absorbed from the digestive tract. Nine grams of cholestyramine for oral suspension, USP contain 4 grams of cholestyramine resin. It is represented by the following structural formula:

  


Representation of structure of main polymeric groups

Inactive ingredients: citric acid monohydrate, colloidal silicon dioxide, propylene glycol alginate, sucrose, xanthan gum, orange flavor, D&C yellow No. 10 alum lake, FD&C yellow No. 6 alum lake.
Red blood cell (RBC) transfusion will be only given when hemoglobin falls below 7 g/dL since ICU admission until the discharge of intensive care unit. Following administration of 1 RBC unit, a repetition of the hematocrit is performed; if a patient's hemoglobin is 7 g/dL or higher, no additional transfusion is necessary.
It has been known from many years that most mushrooms with known effects against cancer . However the components responsible for such action have not been clearly defined. In the present study Pleurotus ostreatus mycelia were grown in submerged culture and the bioactive polysaccharides were extracted from mycelia & culture broth by repeated precipitation with ethanol. The structure of the polysaccharide is mainly glucan. The C13 NMR signals indicating that the polysaccharides is highly branched mainly 1-3 and 1-6 linkage. The results showed that the polysaccharides possess anticancer activity against Ehrlich ascites carcinoma & oesophageal cancer cell line. Mushroom polysaccharides showed direst & indirect antirumour activity.
Methods: An authorization for translating the survey into Spanish was obtained from the survey authors. The translation and cross-cultural adaptations were carried out based on guidelines and international criteria proposed by Sperber. The NEQOL was translated independently from English into Spanish by two professional translators. Each one provided a written report, which was combined by the authors in a new version that contained the most reliable translation for each question. The new version was back translated to English by two different professional translators, who were blinded to the original version of the NEQOL. A new English version was developed by combining the written reports. The aim of the back translation was to compare each item of the new English version with the original NEQOL. Each item of the new English version was compared with the original questionnaire by 30 native English speakers. The success of the translation was evaluated using two scales of comparison: comparability of language and similarity of interpretability. Each one used Likert scales ranging from 1 (extremely comparable/ extremely similar) to 7 (not at all comparable/ not at all similar). A mean score for each question was obtained. Questions with mean scores of three or less were included in the Spanish version. The Spanish version of the NEQOL was tested on 10 subjects diagnosed with GERD, each subject provided feedback on the survey content, which was used to make final corrections. The questionnaire contains fourteen questions; every statement refers to the impact of the esophageal condition in the quality of life. There are five options ranking from not at all true to very true, with every option meaning a numerical value, a higher grade in the questionnaire will express a better quality of life and a low impact in the health-related quality of life.

Patients above 18 years old with chronic esophageal disorders, that require a functional esophageal test such as ph-impedanciometry and/or high-resolution manometry, will be included. Written informed consent will be obtained. All participants will complete the questionnaire before performing the functional esophageal tests and a gastroenterologist specialized on functional esophageal pathology will perform the esophageal tests and analyze the results. Finally, the data from the questionnaire will be compared with the esophageal tests results in order to stablish if there is a correlation between the impact in the quality of life measured by the questionnaire and the tests results.

Statistical analysis: Base line characteristics will be analyzed using Chi-square o Fisher Test for categorical variable, and the Mann-Whitney Test for continuing variables. Continuous variables will be expressed as mean +/- standard deviation. The sensitivity, specificity, predictive values and accuracy will be calculated with the 95% Confidence Interval (95% CI). A P value of less than 0.05 was considered to be statistically significant. All the statistical analysis was performed using SPSS software suite v.22.
OBJECTIVE: Parents have a profound influence on their children's dietary habits. Parents' perspectives, attitudes, and behaviors regarding feeding their children a nutritious diet can have a significant impact on their children's health. The objective of this study was to examine the attitudes, beliefs, and feeding practices of parents in relation to nutrition for their children and to determine how these factors influence strategies for preventing obesity.
SUBJECTS AND METHODS: A total of 446 Saudi mothers with children aged 2-12 years were recruited for this study. The Child Feeding Questionnaire (CFQ) was administered to mothers via an instant messaging application.
RESULTS: Mothers' age showed a significant difference in perceived responsibility (p < 0.004), perceived parental weight (p = 0.000), perceived child's weight (p = 0.000), and concern about the child's weight (p = 0.000). Mothers with postgraduate degrees exhibited a significant difference in perceived child weight (p < 0.003); occupational status showed a significant difference in perceived parental weight (p < 0.004), perceived child weight (p < 0.001), and residence, particularly in Riyadh, which showed a significant difference in perceived parental weight (p < 0.026). There were also significant differences in body mass index (BMI) (p = 0.000) and perceived parental weight in relation to the mother's age. Mothers' age was significantly related to food restrictions (p = 0.000), pressure to eat (p = 0.000), and monitoring (p < 0.009). Mothers with only one child displayed significance in relation to pressure to eat (p < 0.019), while government-employee mothers showed a significant relationship with food restrictions (p < 0.005). There was a noteworthy association between the age of the mothers and perceived responsibility (p < 0.001), occupation (p < 0.22), residence (p = 0.000), and the mother's BMI (p = 0.000) with perceived parental weight. Finally, occupation (p < 0.006) was found to significantly influence food restriction, while the mother's age was significantly related to the pressure to eat (p < 0.002).
CONCLUSIONS: Parental attitudes, practices, and beliefs regarding child feeding were strongly associated with maternal age, occupation, and BMI. Targeted interventions should be developed to assist mothers exhibiting these characteristics in establishing healthier and more effective feeding routines for their children. For example, interventions could be designed to educate parents on the latest findings regarding child-feeding habits and help them develop a greater sense of responsibility for their children's nutrition.
Participants will receive oral lenvatinib 18 mg QD plus oral everolimus 5 mg QD as the starting dose in Cycle 1 or later (cycle length =28 days) during randomization phase. After the data cutoff for the primary analysis, participants will receive study treatment as continuous 56-day cycles.
The present invention discloses EGCG-zinc complex solid dispersion and a preparation method and application thereof. The mass ratio of EGCG-zinc complex to PVP-k30 is 1: 4 to 1: 30 in the EGCG-zinc complex solid dispersion, the preferable ratio is 1:5 to 1: 20, and the optimum ratio is 1:6 to 1:16. EGCG is dissolved in deionized water, a saturated zinc salt solution is dripped in while stirring, and nitrogen for protection is led in; when settling is completed, sediments are collected, then, the sediments are suspended by the deionized water and are collected, and the EGCG-zinc complex is obtained. The EGCG-zinc complex and polyvinylpyrrolidone are proportionally mixed and dissolved in water, nitrogen for protection is led in, the mixed liquid is homogenized through a high-pressure homogenizing machine and is filtered, and the filtrate is dried in a spray mode to obtain the EGCG-zinc complex solid dispersion. The EGCG-zinc complex solid dispersion overcomes various defects existing in the EGCG, and has conspicuous curative effects on the therapy of various senile diseases; the EGCG-zinc complex solid dispersion solves the common problems in the therapy of senile diseases that the adaptive symptom of medication is single, and the curative effect is not ideal. The EGCG-zinc complex solid dispersion has the advantages of simple preparation method and broad application prospect.
Patients continue receiving their SOC chemotherapy regimen at home for approximately 24 weeks in the absence of disease progression or unacceptable toxicity. This includes drug administrations, injections/infusions and routine clinical laboratory tests in the home from the HHNP, overseen by Mayo Clinic's home health program CCBW Command Center. Patients are also provided biometric devices for health monitoring vital signs, as well as a computer tablet for video visits with the Mayo Clinic care team.