anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses an external traditional Chinese medicine composition for treating toothache. The traditional Chinese medicine composition consists of the following bulk pharmaceutical chemicals: 2-5g of syzygium aromaticum, 2-5g of frankincense, 2-5g of pericarpium zanthoxyli, 2-5g of indigo naturalis, 1-3g of asarum, 2-5g of nidus vespae, 0.1-0.3g of borneol, 1.2-1.8g of borax and 2-5g of mirabilitum dehydratum. A preparation method of the traditional Chinese medicine composition comprises the following steps: grinding the raw materials into fine powder, screening by a 100-mesh sieve and uniformly mixing to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition is externally used in treatment; 0.1-0.3g of the traditional Chinese medicine composition is used each time; 0.1ml of sesame oil and 0.1g of bluish white salt are added for mixing and applying; the traditional Chinese medicine composition is applied to the affected part for 2-4 times per day before going to the bed after eating and at night; vomit and swallow by mistakes can brought to a patient; and generally, the toothache can be cured in one week. The external traditional Chinese medicine composition is mainly used for treating toothache caused by various oral inflammations and decayed teeth and is applied to sore swollen parts in a mouth and on teeth, thereby enhancing the function of relieving pains. The external traditional Chinese medicine composition has the advantages of having good treatment effect, taking effect quickly and being unlikely to recur after healing.
BACKGROUND: Transplantation of hearts from hepatitis C virus (HCV)-positive donors has increased substantially in recent years following development of highly effective direct-acting antiviral therapies for treatment and cure of HCV. Although historical data from the pre-direct-acting antiviral era demonstrated an association between HCV-positive donors and accelerated cardiac allograft vasculopathy (CAV) in recipients, the relationship between the use of HCV nucleic acid test-positive (NAT+) donors and the development of CAV in the direct-acting antiviral era remains unclear.
METHODS AND RESULTS: We performed a retrospective, single-center observational study comparing coronary angiographic CAV outcomes during the first year after transplant in 84 heart transplant recipients of HCV NAT+ donors and 231 recipients of HCV NAT- donors. Additionally, in a subsample of 149 patients (including 55 in the NAT+ cohort and 94 in the NAT- cohort) who had serial adjunctive intravascular ultrasound examination performed, we compared development of rapidly progressive CAV, defined as an increase in maximal intimal thickening of ≥0.5 mm in matched vessel segments during the first year post-transplant. In an unadjusted analysis, recipients of HCV NAT+ hearts had reduced survival free of CAV ≥1 over the first year after heart transplant compared with recipients of HCV NAT- hearts. After adjustment for known CAV risk factors, however, there was no significant difference between cohorts in the likelihood of the primary outcome, nor was there a difference in development of rapidly progressive CAV.
CONCLUSIONS: These findings support larger, longer-term follow-up studies to better elucidate CAV outcomes in recipients of HCV NAT+ hearts and to inform post-transplant management strategies.
BACKGROUND: Pelvic congestion syndrome (PCS) is associated with chronic pelvic pain (CPP). The efficacy of flavonoids for treating PCS symptoms is still a matter of debate, and little has been published. The aim of this study was to assess the efficacy of a mixture of diosmin, troxerutin, and hesperidin in improving symptoms of patients with PCS, observing a direct effect on circulation by specific color Doppler ultrasonography (CDU) evaluations.
METHODS: This was a pilot, prospective, independent, cross-over, daily-diary-based trial. Women were evaluated with CDU for 3 times (baseline, 60 days, 120 days). Data about N.=13 women who completed the study were analyzed.
RESULTS: During the treatment, we recorded a significant reduction of intermenstrual and menstrual pain intensity (total points) (P<0.05). The satisfaction after treatment was significantly higher than after placebo (P<0.0001). A significant reduction in the diameter of the major ovarian vein (P=0.004 compared to placebo), associated with an increase in peak systolic velocity (P=0.01) and a corresponding significant increase in the Resistivity Index (P<0.0001) were recorded during treatment.
CONCLUSIONS: The use of a mixture of diosmin, troxerutin and hesperidin in women with PCS can significantly help to manage typical symptoms of pelvic pain and it is associated with an evident Doppler effect on pelvic microcirculation.
To reduce postpartum depression among the primiparous puerperal women in the intervention group, and a nursing care program was implemented under the guidance of Levine's model. This program was applied with 7 home visits between the 8th and 80th postpartum days. Face-to-face training and training booklets were provided in home visits. As of the fourth home visit, Pilates exercises were performed.
Loss of AT-interacting domain-rich protein 1A (ARID1A) frequently occurs in human malignancies including lung cancer. The biological consequence of ARID1A mutation in lung cancer is not fully understood. This study was designed to determine the effect of ARID1A-depleted lung cancer cells on fibroblast activation. Conditioned media was collected from ARID1A-depleted lung cancer cells and employed to treat lung fibroblasts. The proliferation and migration of lung fibroblasts were investigated. The secretory genes were profiled in lung cancer cells upon ARID1A knockdown. Antibody-based neutralization was utilized to confirm their role in mediating the cross-talk between lung cancer cells and fibroblasts. NOD-SCID-IL2RgammaC-null (NSG) mice received tumor tissues from patients with ARID1A-mutated lung cancer to establish patient-derived xenograft (PDX) models. Notably, ARID1A-depleted lung cancer cells promoted the proliferation and migration of lung fibroblasts. Mechanistically, ARID1A depletion augmented the expression and secretion of prolyl 4-hydroxylase beta (P4HB) in lung cancer cells, which induced the activation of lung fibroblasts through the β-catenin signaling pathway. P4HB-activated lung fibroblasts promoted the proliferation, invasion, and chemoresistance in lung cancer cells. Neutralizing P4HB hampered the tumor growth and increased cisplatin cytotoxic efficacy in two PDX models. Serum P4HB levels were higher in ARID1A-mutated lung cancer patients than in healthy controls. Moreover, increased serum levels of P4HB were significantly associated with lung cancer metastasis. Together, our work indicates a pivotal role for P4HB in orchestrating the cross-talk between ARID1A-mutated cancer cells and cancer-associated fibroblasts during lung cancer progression. P4HB may represent a promising target for improving lung cancer treatment.
The daily treatment session had eight children along with their major caregivers. The treatment was conducted by two experienced occupational therapists (OT), and each session lasted for four hours in the week-day morning with a 10-minute break. The goal of the sessions was to enhance children's development through cognitive training, behavioral modification plan and parenting skill training. Said therapists assisted the caregivers in improving their nurturing and parenting skills with their children, as well as their techniques with regards to influencing them.
Capsulated decaffeinated green tea extract (dGTE) (standardised to 70% EGCG concentration, 571mg total per day, containing 400mg EGCG - provided by Biocare Ltd., UK using standard 00 vegetable capsules (hydroxypropyl methylcellulose). Dosage: 2 divided doses (1 capsule mid morning, 1 capsule mid afternoon) - daily for 8 weeks.
Intervention involves exercise starting at 50% of maximum age-adjusted heart rate (MHR) for 10 minutes (warm-up and Recovery)_ plus 5 minutes of target heart rate per day 5 days a week for 2 weeks, supervised by the athletic trainer or parent. The protocol increases the intensity of target heart rate by 10% MHR and duration of 50% MHR by 2 minutes every 2 weeks if there is no symptom exacerbation. The exercise protocol includes treadmill speed and track minutes per lap conversion, rate of perceived exertion and talk test for each stage of exercise plus total time to execute for 5 days each week.
PURPOSE:To provide a pharmaceutical preparation for topical application having prolonged action and useful for the mitigation or prevention of the spasm of muscles, by using a drug layer containing a pressure-sensitive adhesive substance and a nitrite-type vasodilator as essential components, and a flaxible substrate supporting said drug layer. CONSTITUTION:The objective pharmaceutical preparation for topical application is prepared by applying a drug layer containing a nitrite-type vasodilator (e.g. nitroglycerine, glycol dinitrate, etc.) for the mitigation or prevention of the spasm of muscles and a pressure-sensitive adhesive substance, to a flexible substrate. The thickness of the drug layer is about 10-300mum. The pressure- sensitive adhesive substance is, e.g. an acrylic resin composition, a rubber composition, etc. The vasodilator acts to the diseased part continuously for >=10hr and the spasm can be effectively prevented by applying the pharmaceutical preparation to the part (e.g. the muscle of the leg) where the spasm is expected.
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty Index (FI) definition to (1) investigate the association between levels of inflammatory markers (baseline) and change in FI score after 8 years of follow-up and (2) investigate the longitudinal associations between inflammatory markers, body composition, and frailty. Home-dwelling elderly (≥ 70 years) were invited to participate in the study and re-invited to a follow-up visit 8 years later. This study includes a total of 133 participants. The inflammatory markers included were high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and glycoprotein acetyls (Gp-acetyls). We used the body composition markers fat mass, fat-free mass, and waist circumference. The FI score consisted of 38 variables. Additional clinical assessments such as blood pressure and body mass index (BMI), as well as information about daily medications, were collected at both visits. Linear regression model and Spearman's rank correlation were used to investigate associations. We showed that the FI score increased after 8 years, and participants with higher hs-CRP levels at baseline had the largest change in the FI score. Changes in fat mass were significantly correlated with changes in hs-CRP and IL-6, and changes in waist circumference were significantly correlated with changes in TNF-α. The use of drugs increased during the 8 years of follow-up, which may have attenuated the associations between inflammation and frailty. However, elevated concentrations of hs-CRP in the elderly may be associated with an increased risk of frailty in subsequent years.
A total of 32 cadaveric fingers with bony mallet injuries were fixed using either the hook plate or the pull-out suture technique. The purpose of this study was to assess the immediate postoperative biomechanical responses of the fixation techniques under different load conditions. The fingers were cyclically loaded with a force of 7 N for 3500 cycles and until construct failure. The maximum displacements of the hook plate and pull-out sutures were 0.7 mm and 0.6 mm, respectively (p = 0.556). The stiffnesses of the hook plate and pull-out suture were 1.3 N/mm and 1.1 N/mm, respectively (p = 0.515). The ultimate loads-to-failure for the hook plate and pull-out suture were 64.4 N (interquartile range [IQR] 37.7-77.7) and 44.5 N (IQR 29.7-63.5), respectively (p = 0.094). Both fixation techniques were able to withstand immediate postoperative mobilization without any difference in fracture displacement, construct stiffness or maximum load to failure.
Cough is a common experience and the most frequent reason why an individual seeks a visit to a physician. The prevalence of cough is about 10+% of the population. Cough is a manifestation of many aerodigestive tract disorders and especially consequential for serious lower airway diseases such as respiratory infections, chronic obstructive pulmonary disease (COPD) and asthma because increased coughing leads to emergency room visits and hospitalization. There is a need for methods to oversee coughing frequency in certain patients. Traditionally, all automated cough monitors have used cough sound as the signal for the measurement of cough. In the present invention movements of the diaphragm muscle, recorded by a motion sensor placed above the xiphoid process, are used for counting coughs. A device for such recordings is described and data were collected. This method is validated by using citric acid spray to trigger cough sounds and to show that the provoked acoustic signal is matched by the electronic signals from the movement sensors. The xiphoid process is a unique anatomical landmark for the non-acoustic detection of cough.
Intra-rater and inter-rater validity and reliability of trunk flexion, extension and right-left lateral flexion isometric muscle strength in cases with AIS will be performed with the Lafeyette hand dynamometer device ((Lafayette Manual Muscle Testing System, Lafayette Instrument Co, Lafayette, Indiana). To avoid systematic error, each participant will perform the isometric handheld dynamometer protocol in a random testing order. In order to determine inter-rater reliability, the same hand dynamometer protocol will be applied to each participant by two different assessors on the first day of the test. Participants will be given a 1-hour rest period between evaluators to prevent fatigue in the evaluations to be held on the same day. To determine inter-rater reliability and agreement, participants will be re-evaluated by the same researchers, at the same protocol, place and day, with a 1-week interval to prevent learning effects.
The present invention discloses a novel technology for extracting total flavone of epimedium herb. Medicinal materials (namely epimedium herb) are decocted with water and are filtered, filtrate is concentrated, ethanol is added, sufficient stirring is carried out, the solution is placed and is filtered, alkali or alkali oxide is added in filtrate, the pH value reaches 7 to 9, filtration is carried out, the filtrate is regulated to be neutral, ethanol is recovered, residue is eluted with water until eluent is yellowish through a pretreated resin column, 70% of ethanol is used for elution, and total flavone is obtained by recovering ethanol. The present invention uses water as extraction solvent and adopts a resin column purification method. The present invention has the advantages of economy, environmental protection, reduced reduce production cost and avoidance of the use of unsafe factors of organic solvent, such as ethyl acetate, methanol, etc. in production. The technology of the present invention replaces existing technological organic solvent repeated extraction methods, and the purity of products is improved to more than 70%. The technological method also has the advantages of convenience and no need of complex devices, and is suitable for industrialization production.
Continuous femoral nerve block with bolus of ropivacaine 0.5% and then continuous infusion of ropivacaine 0.2 % 4 - 6 ml/h, associated with paracetamol and ibuprofen. Each group will contain 30 patients.
Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a plurality of sets of words. Each set of words in the plurality of sets of words includes a word annotated as being an entity having a same custom entity type. The program further determines a plurality of word embeddings in a word embedding space for the plurality of annotated words. The program also defines a region in the word embedding space based on the received plurality of word embeddings. The program further receives a set of words. The program also determines a word embedding for a subset of the set of words. The program further determines whether the word embedding falls within the defined region in the word embedding space. Upon determining that the word embedding falls within the defined region in the word embedding space, the program also determines that the subset of the set of words represents an entity having the custom entity type.
Endoscopic submucosa dissection (ESD) has been applied extensively in the treatment of large intestine tumours due to its high total excision ratio. Nevertheless, there is a high incidence of adverse reactions in colon ESD, and the efficacy of prophylactic ESD following ESD in prevention of postoperative haemorrhage is still disputed. The purpose of this meta-analysis is to evaluate the effectiveness of prophylaxis of wound closure in large intestine ESD after operation. For eligibility, we looked through three databases: PubMed, Embase and Cochrane Library. Heterogenity was measured by means of a chi-square method of Q-statistic and an I2 test. Fixed or random effects models were used for data processing. Based on the retrieval policy, we found a total of 1286 papers, and then we collected nine papers to extract the data. Regarding postoperative haemorrhage, there was a significant reduction in the risk of wound haemorrhage in the wound closure group than in the control group (OR, 0.29; 95% CI, 0.19-0.44 p < 0.0001). No statistical significance was found in the incidence of perforation in the wound closure and the control group (OR, 0.45; 95% CI, 0.19-1.03 p = 0.06). There was a significant reduction in the incidence of postoperation fever among those in the wound closure group than in the control group (OR, 0.37; 95% CI, 0.15-0.93 p = 0.04). Preventive endoscopic closure decreased the rate of ESD in colon disease, but did not significantly decrease the rate of postoperation perforation and postoperative fever. Future research will be required to clarify the risk factors and classify high-risk individuals in order to formulate a cost-effective prevention strategy.
This 3-year project will include two groups of participants: 1) young men accustomed to resistance training (study #1) and 2) young men accustomed to endurance training (study #2). Inclusion will be limited to healthy participants (i.e. nonsmokers, normotensive with systolic and diastolic values \<135/85 mmHg, non-obese, non-medicated, and free of any known disease as assessed by medical history) (Pickering, Hall et al. 2005). Month 1-3 will focus on literature review and month 4 to 8 will address experimental settings preparation and selection of participants to include in each study. Testing and data collection will be scheduled for months 9-14 and 13-18 (study # 1 and 2 related testing, respectively). Data processing, analysis and presentation will occur from month 21 to 33. All participants will read and sign an informed consent document with the description of the testing procedures. The Faculty's ethical committee will be asked to approve this document before testing. All studies will follow a randomized crossover design, with measures taken before and after the defined IF periods and participants of each group serving as their own controls. Two groups of participants will be included in this project: 1) group #1: resistance trained group (tested for neuromuscular function, anaerobic capacity and body composition); 2) group #2: endurance trained group (tested for aerobic and anaerobic capacity and body composition). In a randomized, counterbalanced manner, all participants will be tested in two different conditions: control condition (pre- and post4 wks of normal diet) vs. experimental condition (pre- and post-4 wks of IF). A 2-wk washout period will separate both conditions. Measurements will be taken during the morning period (between 07:00 and 11:00 am) in the fasted state. Neuromuscular function and anaerobic capacity will be assessed on separate days (with at least a 48- hour interval) to ensure full recovery.
PURPOSE: Patients with ureteric stents have symptoms that overlap with infection symptoms. Thus, clinicians unnecessarily give antibiotics to stented patients with bacteriuria despite guidelines. In stented patients, little is known about risk factors for developing bacteriuria or urosepsis. The objectives were to identify the frequency and risk factors for developing bacteriuria and urosepsis in patients with stents.
METHODS: In this retrospective cohort study, we reviewed patients with ureteric stents placed or exchanged over 1 year. We examined associations between bacteriuria or urosepsis and host risk factors. Univariable and multivariable logistic analyses were performed.
RESULTS: Of 286 patients (mean age: 57.2 years), 167 (58.4%) were male. The main stent indications were stone, stricture, cancer and extrinsic compression. The median stented period was 61 days. The frequency of bacteriuria was 59/286 (21%). ASA status 3 and 4 had 5 times the odds of having bacteriuria relative to ASA status 1. Stent duration > 2 months had 5.5 times the odds relative to ≤ 2 months. Urosepsis was infrequent, 13/286 (4.5%). Five patients had bacteraemia. A stent duration over 2 months had nearly 6 times the odds of urosepsis.
CONCLUSION: ASA status higher than 2 and stent time greater than 2 months raise the odds of developing bacteriuria. A stent duration longer than 2 months was the only predictor of urosepsis. Though 21% of patients had bacteriuria, 4.5% had urosepsis. Hence, bacteriuria without sepsis should not be treated with antibiotics, thus aiding antimicrobial stewardship.
PROBLEM TO BE SOLVED: To obtain an oral melanogenesis inhibitory composition which shows no adverse drug reactions, enables us to give generalized whitening effectiveness without being affected with perspiration friction and prevents or improves pigmentation by including an extract from a rose or a chrysanthemum as an active ingredient. SOLUTION: This oral melanogenesis inhibitory composition is obtained by including an extract from a rose or a chrysanthemum, which is obtained by means of drying a plant sample, e.g. stems, roots, leaves, flowers, seeds or the like of the rose, e.g. rose gallica or the like, or the chrysanthemum, e.g. Chrysanthemum morifolium or the like, finely grinding the sample by a mill or the like to crush it into pieces, extracting it at 60-70 deg.C for 20-60 min by the use of a solvent, e.g. water, acetone, methanol or the like, followed by filtration to remove solids and concentrating the resultant filtrate under reduced pressure or lyophylizing the filtrate, as an active ingredient.  Further, it is favorable that the oral melanogenesis inhibitory composition is added to a food, e.g. fruit beverage, coffee or the like, preferably in a proportion of 10-30 wt.% and taken in a daily amount of 0.05-1 g per an adult as a condensed extract.