anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To readily and practically obtain the subject substance useful as a remedy, etc., for obesity by heat-treating a supernatant of an aqueous extract solution obtained from wheat (flour), removing denatured proteins and subjecting the resultant extract solution to concentrating treatment using an ultrafiltration membrane. CONSTITUTION:A supernatant of an aqueous extract solution obtained from wheat or wheat flour is heated at, e.g. 85-90 deg.C, to denature unnecessary proteins contaminating the supernatant. The produced denatured proteins are removed by centrifugation of allowing the supernatant to stand. The obtained aqueous solution is then subjected to concentrating treatment using an ultrafiltration membrane (e.g. membrane capable of cutting 100000 molecular weight) and, as necessary, dried by spraying, freezing, etc., to afford the objective substance. Furthermore, the extract solution is preferably filtered through filters having e.g. 3 and 1mum diameter, before the treatment with the ultrafiltration membrane and then passed through a precise filtration membrane having 0.2mum diameter to carry out degerming, etc.
An electronics module ( 100 ) for a wearable article ( 200 ) comprises a controller. The electronics module receives biosignals such as ECG signals from sensors on the wearable article and processes these signals to provide data and information to a user. The controller is operable to apply filters to the incoming biosignals that have been digitised and processed by an analogue to digital converter. The filters are provided to remove, or at least mitigate, noise from the digital signal. An example of noise that could be advantageously removed is electromagnetic interference at mains frequencies. Mains frequencies are typically 50 Hz or 60 Hz depending upon location. The controller is configured to apply a suitable filter depending upon the location, which is determined from a GPS signal from a GPS device on the electronics module or on a remote mobile device ( 100 ). This has the advantage of being able to easily and quickly select and apply the relevant filter depending upon the location.
BACKGROUND: Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors. However, how to effectively deliver neoantigens to induce robust antitumor immune responses remains a major obstacle.
RESULTS: Here, we developed a safe and effective neoantigen peptide delivery system (neoantigen-ferritin nanoparticles, neoantigen-FNs) that successfully achieved effective lymph node targeting and induced robust antitumor immune responses. The genetically engineered self-assembled particles neoantigen-FNs with a size of 12 nm were obtained by fusing a neoantigen with optimized ferritin, which rapidly drainage to and continuously accumulate in lymph nodes. The neoantigen-FNs vaccine induced a greater quantity and quality of antigen-specific CD8+ T cells and resulted in significant growth control of multiple tumors, dramatic inhibition of melanoma metastasis and regression of established tumors. In addition, no obvious toxic side effects were detected in the various models, indicating the high safety of optimized ferritin as a vaccine carrier.
CONCLUSIONS: Homogeneous and safe neoantigen-FNs could be a very promising system for neoantigen peptide delivery because of their ability to efficiently drainage to lymph nodes and induce efficient antitumor immune responses.
PROBLEM TO BE SOLVED: To obtain a hair grower excellent in depilation-preventive effect and hair growing effect, containing a combination of specific plant extract(s) with an amine oxide. SOLUTION: This hair grower contains 0.005-20wt.%, on a dry basis, of extract(s) from Paeonia lactiflora Pallas (Paeonia albiflora Pallas var. irichocarpa Bunge) and/or Paeonia suffruticosa Andrews (Paeonia mountan Sims) (Paeoniaceae) and 0.0001-20wt.% of an amine oxide of the formula (R<1> is a 2-24C alkyl; R<2> is methyl or hydroxyethyl; A is monoxyethylene; (n) is 0-5) (e.g. N,N-dihydroxymethyl-2-dodecylamine oxide). The former extract is obtained from the root of the corresponding plant, while the latter extract from the root bark of the corresponding plant. The extractant to be used is an organic solvent. This hair grower is effective for treating/preventing depilation, being administered through direct coating or spraying on the skin; its daily dose is 0.01-100mg/kg for adult in one to four portions per day.
Kava kava (KAV) is a plant-derived treatment widely used in Europe to treat anxiety disorders. Several studies suggest that KAV may be effective in reducing anxiety symptoms; however, trial data are limited. This study will compare KAV, the drug venlafaxine-XR (VEN), and placebo for the treatment of GAD.

This study will last 10 weeks. Participants will be randomly assigned to receive KAV, VEN, or placebo for 8 weeks. Participants will then undergo a 1-week tapering of their medication followed by an additional week of observation. Self-report scales and questionnaires will be used to assess the anxiety, depression, and functional impairment of participants. Side effects, vital signs, and laboratory measures will be monitored throughout the study.
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. The invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 3 to 50 parts of heartleaf houttuynia herb, 3 to 30 parts of wild chrysanthemum flower, 6 to 20 parts of great burdock achene, 1 to 10 parts of villous amomum fruit, 1 to 20 parts of dried ginger, 1 to 20 parts of swordlike atractylodes rhizome, 4 to 30 parts of Indian buead, 3 to 90 parts of wild buckwheat rhizome, 1 to 20 parts of honey-fried licorice root and 6 to 60 parts of lalang grass rhizome. The traditional Chinese medicine composition provided by the invention is prepared into the extract according to the proportion, and can obviously inhibit the expression of inflammatory factors. The invention also provides the function of the traditional Chinese medicine extract in the anti-inflammatory aspect and the application in the aspect of preventing novel coronavirus pneumonia. The tea substitute prepared from the traditional Chinese medicine composition provided by the invention has the main functions of: dispelling wind, removing toxic substance, and eliminating dampness with aromatics. Is suitable for preventing COVID-19 in common healthy people, the old with poor resistance and the close contact person of the novel coronavirus pneumonia positive patient.
An iterative data collection study to continuously assess the performance of our Entia Liberty device with cancer patients. Our device enables a full blood count from a finger prick sample. The participants enrolled in the study will attend the study site for their routine venepuncture blood test. Once enrolled, they will have a finger prick test obtained by a Healthcare Professional (trained member of the clinical research team) to be tested on an Entia Liberty device. Within 4 hours of that same participant's routine venepuncture, a small amount of blood from the venepuncture will be also tested on a second Entia Liberty device in the laboratory. All the results from the capillary finger prick Liberty test, routine venepuncture blood test (gold standard reference method) and the venous blood Liberty test will be compared against each other to regularly assess that the improvements made on the measurement system of the device is sufficient.
Pts receive azurin-derived cell-penetrating peptide p28 IV over 15 min 3x/week for 4 wks. Tx repeats every 6 weeks for up to 10 courses in the absence of disease progression or unacceptable toxicity.
In transplantation, hypothermic machine perfusion (HMP) has been shown to be superior to static cold storage (SCS) in terms of functional outcomes. Ex vivo machine perfusion offers the possibility to deliver drugs or other active substances, such as Mesenchymal Stem Cells (MSCs), directly into an organ without affecting the recipient. MSCs are multipotent, self-renewing cells with tissue-repair capacities, and their application to ameliorate ischemia- reperfusion injury (IRI) is being investigated in several preclinical and clinical studies. The aim of this study was to introduce MSCs into a translational model of hypothermic machine perfusion and to test the efficiency and feasibility of this method. Methods: three rodent kidneys, six porcine kidneys and three human kidneys underwent HMP with 1-5 × 106 labelled MSCs within respective perfusates. Only porcine kidneys were compared to a control group of 6 kidneys undergoing HMP without MSCs, followed by mimicked reperfusion with whole blood at 37 °C for 2 h for all 12 kidneys. Reperfusion perfusate samples were analyzed for levels of NGAL and IL-β by ELISA. Functional parameters, including urinary output, oxygen consumption and creatinine clearance, were compared and found to be similar between the MSC treatment group and the control group in the porcine model. IL-1β levels were higher in perfusate and urine samples in the MSC group, with a median of 285.3 ng/mL (IQR 224.3-407.8 ng/mL) vs. 209.2 ng/mL (IQR 174.9-220.1), p = 0.51 and 105.3 ng/mL (IQR 71.03-164.7 ng/mL) vs. 307.7 ng/mL (IQR 190.9-349.6 ng/mL), p = 0.16, respectively. MSCs could be traced within the kidneys in all models using widefield microscopy after HMP. The application of Mesenchymal Stem Cells in an ex vivo hypothermic machine perfusion setting is feasible, and MSCs can be delivered into the kidney grafts during HMP. Functional parameters during mimicked reperfusion were not altered in treated kidney grafts. Changes in levels of IL-1β suggest that MSCs might have an effect on the kidney grafts, and whether this leads to a positive or a negative outcome on IRI in transplantation needs to be determined in further experiments.
A male patient in his 50s presented to the emergency department with a three-day history of shortness of breath, New York Heart Association class IV, and oxygen desaturation. His physical examination revealed a large volume radial pulse with bibasal crepitation in the lungs and a soft diastolic murmur in the aortic area on auscultation of his heart. He was managed on the line of decompensated heart failure. Transthoracic echocardiography showed a dissection flap in the ascending aorta with acute severe aortic regurgitation. A subsequent urgent CT angiography of the whole aorta confirmed a complex type A aortic dissection with an aneurysmal ascending aorta. An emergency type A aortic dissection repair (modified Bentall's procedure) was done. The patient made a good recovery, was discharged successfully 2 weeks after the procedure and was doing well on postoperative follow-up.
The utility model relates to an ointment patch with a multilayered structure, which belongs to the technical field of externally used medicines and consists of ointment cloth, impermeable pearly-luster membranes, an impermeable ring, a non-woven fabric, ointment and composite paper. One pearly-luster membrane is placed on the ointment cloth, the impermeable ring is placed on the impermeable pearly-luster membrane, the non-woven fabric and the ointment are placed in the impermeable ring, the other impermeable pearly-luster membrane and the composite paper adhered with the periphery of the ointment cloth are covered at the top of the impermeable ring, and an inverted-3-shaped opening is manufactured at the edge of the composite paper. The ointment is fixed on the skin of a patient via the ointment cloth and the impermeable ring, the impermeable pearly-luster membrane and the non-woven fabric are adopted for the bottom of the ointment, and skin allergy is avoided. The ointment is sealed via the impermeable ring and cannot stain clothes of the patient during usage. The impermeable pearly-luster membrane is covered on the ointment, and moisturizing and impermeability of the ointment can be realized. The problem that ointment is easy to spill to the periphery when a traditional ointment patch is used and is easy to stain the clothes of the patient, and the patient is easy to suffer from skin allergy is solved.
A method of administering a food containing at least transfer factor and lactic acid generating bacteria to mitigate the symptoms of a specific human disease prior to medical or drug intervention. Another food formulation consists of transfer factor, lactic acid generating bacteria, and glucans in appropriate combinations. Other components may be added. The food, administered correctly, reduces cortisol levels, builds the immune system, and balances the endocrine system. Dosage amounts are adjusted for client weight. The method may be used with other treatment options.
The invention discloses novel radioactive 18F labeled amino acid derivatives, which are used in research on tumor positron emission tomography (PET) imaging. The derivatives are characterized in that one end of the derivatives is provided with F substituted alkoxy benzoyl structure, and the other end of the derivatives is provided with alpha-amino acid structure; substituent R1 is positioned on an alpha site of carboxyl group and is hydrogen, methyl group, ethyl group, propyl group, isopropyl group, butyl group, methylthio-ethyl group, methyl acetate group or propionate carbomethoxy group; R2 is methoxy group; and n is a number between 1 and 5. The R1 is hydrogen, methyl group, ethyl group, propyl group, isopropyl group, butyl group, methylthio-ethyl group, methyl acetate group or propionate carbomethoxy group; the R2 is hydrogen; and the n is a number between 1 and 5. Compounds improve fat solubility. Different amino acid structures are introduced into the structure, and F in the structure is 19F and 18F. Compared with the prior art, the 18F labeled amino acid derivatives provided by the invention have better discrimination degree of biological distribution, the potential of being used as a tumor imaging agent (particularly a brain tumor imaging agent), as well as the characteristics of simple preparation and high labeling rate. The R1 is hydrogen, methyl group, ethyl group, propyl group, isopropyl group, butyl group, methylthio-ethyl group, methyl acetate group or propionate carbomethoxy group; the R2 is methoxy group; and the n is a number between 1 and 5. The R1 is hydrogen, methyl group, ethyl group, propyl group, isopropyl group, butyl group, methylthio-ethyl group, methyl acetate group or propionate carbomethoxy group; the R2 is hydrogen; and the n is a number between 1 and 5.
Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, oncology, and can be used for photodynamic tumour treatment. For this purpose photosensitiser (PS) of chlorine line is introduced intravenously by drop infusion during 10 minutes in dose 0.8 mg/kg of body weight. 10 minutes after finishing PS introduction, retina is irradiated transpupillarly by laser radiation with wavelength corresponding to maximum of absorption of light radiation by PS with energy density 40-50 J/cm2. Irradiation is performed concentrically from zone of vascular arcades to utmost periphery by fields with 4 mm diametre with covering 5% of area of adjacent fields. Next day preparation ranimizumab is introduced to patient intravitreally in dose 0.5 mg. ^ EFFECT: method allows to provide impediment for development of neovascularisation of eye anterior segment with complete organic blockade of anterior chamber angle and further intraocular pressure decompensation, reduces risk of development of inflammatory complications after laser impact on retina.
In Group 1 (control), the staff anesthesiologist will follow the traditional technique for US-guided thoracic epidural insertion. Briefly, the anesthesiologist will use the US to identify and mark the appropriate spot for placement of the thoracic epidural catheter. The US probe is then placed at rest and the anesthesiologist will proceed with thoracic epidural needle insertion following standard techniques.
Participants continued the study drug based on the final dose and regimen administered at the end of the CACZ885N2301 study. All participants received 1 or 2 ACZ885 subcutaneous injections every 4 or 8 weeks.
OBJECTIVE: Recently, two scoring systems have been developed for predicting pain-free outcomes after microvascular decompression (MVD). Evaluation of these scores on large external datasets has been limited. In this study, the authors aimed to evaluate the performance of published MVD scoring systems in predicting pain-free outcome.
METHODS: A total of 458 patients who underwent MVD for trigeminal neuralgia (TN) between 2007 and 2020 and had at least 6 months of follow-up were included in this study. Hardaway and Panczykowski scores were retrospectively computed for each patient and compared with postoperative pain recurrence and pain-free duration.
RESULTS: The mean ± SD area under the receiver operating characteristic curve for predicting any pain recurrence after MVD was 0.567 ± 0.081 using the Hardaway score and 0.546 ± 0.085 using the Panczykowski score. On log-rank tests and Kaplan-Meier analysis, the patients with Hardaway scores of 0-2 had significantly shorter pain-free survival times after MVD than did those with a score of 3. Patients with a Panczykowski score of 1 had a significantly shorter pain-free duration after surgery compared with both patients with scores of 2-3 and patients with scores of 4-5. Patients with Panczykowski scores of 2-3 also had significantly shorter pain-free duration compared with patients with scores of 4-5.
CONCLUSIONS: Both the Hardaway and Panczykowski scores may be useful for predicting postoperative pain-free duration in TN patients, and their utility may be greatest when scores are clustered. Continued refinement of both scoring systems will help to improve our ability to predict patient outcomes after MVD.
The study subjects assigned to the test group blood is drawn before minimum 2 weeks in order to manufacture the test drug. Test group is compared its progression free survival rate after surgery by administering Temozolomide chemotherapy and radiation therapy same as control group with Immuncell-LC (14 times).
BACKGROUND: Aneuploidy in plants commonly presents as large variations in morphology, physiology, biochemistry, and genetic effects owing to its karyotypic imbalance.
RESULTS: In this study, the trait variations of 393 offspring obtained by pollinating Populus alla × Populus glandulosa 'YXY 7' (2n = 2x = 38) with Populus 'Beilinxiongzhu 1#' (2n = 3x = 57) were explored. The results showed several morphological variations in the cotyledons, including two (69.68%), three (24.07%), and four cotyledons (6.25%). Additionally, the progeny exhibited extensive segregation of ploidy levels, ranging from 38 to 74. Furthermore, seedlings with different chromosome numbers varied in growth traits and physiological activities during growth and development. The backcross progeny with 51-60 chromosomes had a significantly larger basal diameter and seedling height than those with other chromosome numbers. The phenotypic correlations between the traits indicated that the dose effect of the chromosomes significantly affected the basal diameter, petiole length, and leaf length, particularly with stomatal length and stomatal density. Weak and negative estimated correlations were observed between the physiological traits associated with photosynthesis and most of the studied traits.
CONCLUSIONS: This study provides new genetic material with different chromosome compositions, which will contribute to analyzing chromosomal function and integrate the variations in chromosomal dosage into Populus breeding programs.
This study consists of two phases. In the first phase, a rule-based automated chatbot will be developed to facilitate mindfulness-based stress reduction (MBSR) interventions. The second phase will employ a single-group pretest-posttest design to evaluate the feasibility, acceptability, safety and preliminary efficacy of the chatbot-based MBSR intervention for university students with self-reported depressive symptoms. The study will be guided by the 'CONSORT 2010 checklist of information to include when reporting a pilot or feasibility trial'. This study specifically targets university students in Hong Kong and the intervention lasts eight weeks.
When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium. (See  WARNINGS). 

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.

In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when amiloride HCl and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Since indomethacin and potassium-sparing diuretics, including amiloride HCl, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.
BACKGROUND Acute aortic dissection (AAD) is a life-threatening medical emergency that requires a high index of clinical suspicion to be diagnosed promptly. The variability in the clinical presentation of AAD has historically made it difficult to identify in the acute setting. There remains significant inter-physician variability in the use of imaging. The median time to diagnosis in the Emergency Department is over 4 h and AAD has a mortality rate of 68% when diagnosis is delayed by over 48 h after onset of symptoms. CASE REPORT We discuss a case of a 69-year-old woman presenting with gastrointestinal symptoms in the Emergency Department who ultimately was found to have AAD. The patient had delayed presentation by 12 h due to misattribution of her rectal tenesmus to irritable bowel syndrome. However, after a thorough history and physical exam, the Emergency Medicine physician appropriately risk-stratified the patient and correctly diagnosed her with a Stanford Type A aortic dissection using a computed tomography study of the chest, abdomen, and pelvis with intravenous contrast. CONCLUSIONS AAD is an uncommon disease often requiring emergency intervention. We summarize the research and scoring systems and discuss the physical exam findings, comorbidities, imaging modalities, and risk stratification tools. Although imperfect, the Aortic Dissection Detection Risk Score with the addition of a D-dimer test is currently the best-validated tool and should be an important part of clinical decision making prior to performing computed tomography imaging.