anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants will dose the toothbrush provided with a strip of reference dentifrice containing 1100 ppm fluoride as sodium fluoride on each brushing occasion and will brush for one timed minute twice daily (morning and evening) for up to 5 weeks. Participants will use the dentifrice for 2 weeks pre tooth bleaching, 1 week during tooth bleaching and 2 weeks post tooth bleaching application. At Week 3, participants will perform the first application of tooth bleaching as per the instructions provided and continue the application once daily for up to 7 days.
A wide array of pathophysiological changes occurring in severe sepsis and septic shock patients may influence antibiotics' pharmacokinetic (PK) properties. The pharmacokinetics and tissue distributions of linezolid achieving effective concentrations are key factors of successful clinical outcomes. To the best of our knowledge, no observational clinical studies are available on the plasma and bronchoalveolar lavage fluid concentrations of linezolid in septic shock patients. Severe pneumonia patients known or suspected to be caused by Gram-positive pathogens will be considered eligible for the study when the attending physician prescribed linezolid as treatment. The plasma and bronchoalveolar lavage fluid concentrations of linezolid are measured in each group at steady state. In an in vitro PK Model, concentration-time curve is drawn to calculate %T\>MIC or AUC0-24h/MIC. Linezolid pharmacodynamics evaluation should be based on bacterial eradication and clinical outcomes.
PURPOSE:A composition for remedying cancers having long prolonged effect and suppressed side effect, obtained by using both a carcinostatic active ingredient compound and a water-soluble alginate. CONSTITUTION:A carcinostatic active ingredient compound such as 5-fluorouracil, alkylating agent, antibiotic, hormone, etc. is blended with a water-soluble alginate (e.g., sodium alginate, potassium alginate, ammonium alginate, amine alginate, etc.). The water-soluble alginate is most preferably used in the form of an aqueous solution, its concentration is 2-10w/v%, preferably 3-8w/v%, and its pH is about 7. Consequently, the prolonged effect is prolonged about three times as long as the original effect and side effects of digestive organ can be suppressed. Safety application range is enlarged by the reduction of side effect and carcinostatic effect is enhanced.
BACKGROUND: Human papillomavirus (HPV) vaccination and Pap tests are recognized as effective preventive measures to reduce the incidence of HPV-related diseases among young adults. The objective of this study was to assess HPV vaccination and Pap test uptake, awareness, and barriers among young adults in the Gulf Cooperation Council (GCC) countries, including Bahrain, Kuwait, Oman, Qatar, the Kingdom of Saudi Arabia (KSA), and the United Arab Emirates (UAE).
METHODS: A comparative cross-sectional study was conducted from January to April 2024, involving 831 young adults aged 18-39 residing in GCC countries. The main outcome measures were HPV vaccination and Pap test uptake rates, awareness of the HPV vaccine and Pap testing, and barriers to vaccination. Data were collected using online platforms. The Chi-square test and Fisher's exact test were used for data analysis.
RESULTS: The UAE had the highest vaccination rate at 18.9% (50/264), followed by Qatar at 5.8% (6/104), and KSA at 4.6% (10/216), p < 0.001. Individuals with health insurance had higher vaccination rates than those without (11% vs. 5.4%, p = 0.006). Awareness of the HPV vaccine was highest in the UAE (49.6%) and KSA (58.8%), while awareness of Pap smear testing among females was similarly high in these countries (62.4% and 65.9%, respectively). However, actual Pap smear testing rates were highest in Bahrain (15.9%) and Qatar (13.4%). The main barriers to vaccination cited by participants were lack of knowledge (53.6%) and the absence of medical recommendations (13.2%).
CONCLUSION: The study's findings suggest the need of targeted educational campaigns to increase HPV vaccine uptake among both genders and Pap test participation among females. Additionally, incorporating HPV screening and vaccination into routine national programs in GCC countries and emphasising the crucial role of healthcare providers in influencing vaccination decisions are recommended strategies.
The clinical problem of neurogenic detrusor overactivity (bladder hyper-reflexia) is among the most serious problems encountered by Veterans with neurologic injuries such as spinal cord injury (SCI). The majority of persons with SCI suffer from neurogenic bladder (73%) and only 17% of persons with traumatic SCI manage their bladders with voluntary micturition. The investigators' long-term goal is to develop and clinically implement a "bladder pacemaker" able to restore bladder continence for Veterans with spinal cord injury (SCI). This proposal will 1) determine the long-term effectiveness of genital nerve stimulation (GNS) to chronically ( 1 year) reduce urinary incontinence and improve quality of life for Veterans with SCI, and 2) develop and produce an effective take home GNS system that can be used by more Veterans, given to Veterans at the end of the study and used in future multi-VA studies.

The rationale for studying chronic GNS is based on the demonstration in humans with SCI that abnormal hyper-reflexive bladder contractions can be acutely inhibited and bladder capacity acutely increased using GNS. The peripheral and easily accessible location of the dorsal genital nerve (DGN) allows surface stimulation and therefore provides the potential for a less complicated surgical intervention than is currently available, increasing the number of individuals who could benefit from bladder control neural prostheses. While GNS has been demonstrated to be effective acutely by multiple groups, relatively few groups have attempted to test this approach for more than a day.
An electronic device and method for disease prognosis using neural network models and based on demographic information and anatomical image, is provided. The electronic device receives demographic information associated with a person. Based on application of a first neural network model on the demographic information, an ailment associated with an anatomical region of the person is determined. Based on the determined ailment, a second neural network model is selected from a set of neural network models. The second neural network model is applied on a received first set of images associated with the anatomical region of the person to determine a first disease severity corresponding to the determined ailment. The second neural network model is different from the first neural network model. A display device associated with the electronic device is controlled to render information about the determined first disease severity and the determined ailment.
* This is a premixed formulation. Do not dilute prior to use. 
  * Discard any unused portion of EMERPHED. 
  * Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. 



EMERPHED is a clear, colorless solution. Do not use if the solution is not clear or if particulate matter is present.
OBJECTIVE: Historically minoritized individuals experience greater exposure to light at night, yet it is unclear whether the association between light at night and sleep duration vary by race/ethnicity or sex. We examined the association between light at night and sleep duration by race/ethnicity and sex.
METHODS: Participants (N = 6089, mean age=49.5, 52% women, 13% Asian, 27% Black, 14% Mexican, 46% White) in the 2011-2014 National Health and Nutrition Examination Survey underwent 9-day of actigraphy. Light at night was defined as light exposure within the 5-hour activity nadir (L5). Sleep duration within a 24-hour period was analyzed as short (<7 hours) or long (>9 hours) compared to recommended (≥7 and <9 hours). Poisson models were fit to estimate the association between light at night and sleep duration after adjustment for covariates.
RESULTS: Light at night was most common among Black participants, who also had the shortest sleep duration. Overall, light at night was associated with 80% higher prevalence of short sleep duration [1.80 (1.49, 2.18)]. Compared to no-light at night, low and high light at night were associated with higher prevalence of short sleep duration, [1.61 (1.31, 1.98) and 2.01 (1.66, 2.44), respectively]. Associations varied by race/ethnicity and sex. Light at night was associated with shorter sleep duration in Black, Mexican and White females and Mexican and White males only. Black males exposed to light at night vs. no-light at night had lower prevalence of long sleep duration. There were no associations between light at night and sleep duration among Asian participants.
CONCLUSION: Light at night was associated with shorter sleep duration, particularly among females. Targeting light exposure may help to improve sleep duration.
The invention relates to medicinal liquor for enhancing Yang and tonifying the kidney. Specifically, the medicinal liquor is prepared by soaking medicines in 75% alcohol or white wine. The medicinal liquor has the effects of tonifying the kidney and enhancing Yang, replenishing essence and enriching blood, strengthening bone and musculature; the multiple medicines are combined for use, and the compatibility of the medicines is ingenious, so that the medicinal liquor has specific effects and great power. The medicinal liquor disclosed by the invention is used for treating impotence or heave without sexual capacity caused by deficiency of the kidney, light-headedness, mental fatigue, soreness and weakness of waist and knees. The medicinal liquor has the effects of treating impotence, uterine cold infertility, frequent urination and dizziness deafness, further enhancing Yang and tonifying the kidney, replenishing essence and enriching blood. By drinking the medicinal liquor, the vigorous energy of people can be kept, the human longevity is prolonged; the medicinal liquor is particularly suitable for the old and the weak. By drinking the medicinal liquor, people enjoy the joy of liquor drinking in the drinking process, and meanwhile the medicinal liquor has the effects of life cultivation, health preservation and disease treatment. The medicinal liquor has important practical significances for prevention and treatment and health care of people.
In controlled trials ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients.

Angioedema of the face, extremities, lips, tongue, glottis, and larynx has been reported in patients treated with ACE inhibitors including MAVIK. Symptoms suggestive of angioedema or facial edema occurred in 0.13% of MAVIK-treated patients. Two of the four cases were life-threatening and resolved without treatment or with medication (corticosteroids). Angioedema associated with laryngeal edema can be fatal. If laryngeal stridor or angioedema of the face, tongue or glottis occurs, treatment with MAVIK should be discontinued immediately, the patient treated in accordance with accepted medical care and carefully observed until the swelling disappears. In instances where swelling is confined to the face and lips, the condition generally resolves without treatment; antihistamines may be useful in relieving symptoms. Where there is involvement of the tongue, glottis, or larynx, likely to cause airway obstruction, emergency therapy, including but not limited to subcutaneous epinephrine solution 1:1,000 (0.3 to 0.5 mL) should be promptly administered. (see PRECAUTIONS - Information for Patients and ADVERSE REACTIONS.)
The present invention discloses a vaccine composition comprising a fusion protein for inducing an enhanced pathogen antigen-specific T cell response. The fusion protein comprises: (a) an Antigen Presenting Cell (APC) binding domain or CD91 receptor binding domain located at the N-terminus of the fusion protein; (b) a translocation peptide of 34-112 amino acid residues in length comprising an amino acid sequence at least 90% identical to SEQ ID No. 4, SEQ ID No. 2, SEQ ID No. 3 or SEQ ID No. 6, C-terminal to the APC binding domain or the CD91 receptor binding domain; (c) an antigen of a pathogen located at the C-terminus of the translocation peptide; (d) a nuclear export signal comprising the amino acid sequence of SEQ ID NO 13; and (e) an endoplasmic reticulum retention sequence located at the C-terminus of the fusion protein.
This group will consist of women who desire uterine preservation. Women will be randomized 1:1 to GFA or uterine artery embolization (UAE).
Disclosed is a Chinese herbal medicine composition used for wound-free bone fractures. The composition consists of the medicinal mushroom liquid extract and ethanol. Wherein the medicinal mushrooms are Antrodia cinnamomea and Phellinus igniarius. The composition contains 42wt%~ 62wt% medical liquid extract and 38wt%~ 58wt% ethanol. The medicinal mushrooms have the effects of diminishing inflammation and making cells rapidly repair and regenerate. Thereby the Chinese herbal medicine composition can make the wound-free bone fractures rapidly reduce damage, relieve pain and accelerate recovery and has the advantage of convenient medicine addition.
Placebo was administered by subcutaneous injection every 2 or 4 weeks depending on the dosing schedule in the protocol for a total of 52 weeks. The first 24 weeks of the treatment period was a fixed steroid phase where the steroid dose was maintained constant; in the following 28 weeks the steroid dose was adjustable, depending on the patient's condition. Following the 52-week treatment period, patients were followed up for an additional 16 weeks.
Ethanol can directly or indirectly lead to cognitive and mental disorders. The long-term intake of alcohol can directly affect the distribution of gut microbiota. Lactobacillus rhamnosus GG (LGG) is a natural bacterium isolated from healthy human intestines that has the function of preventing cytokine-induced cell apoptosis and protecting cell barriers. However, the regulatory effect of LGG on cognitive and mental disorders caused by chronic ethanol exposure (CEE) is still unclear. In this study, we established a CEE mouse model through free alcohol consumption and added LGG or antibiotics in the later stages of the model. Sequencing analysis of the 16S rRNA gene showed that CEE resulted in a decrease in the abundance and diversity of mouse gut microbial communities accompanied by alterations in the relative abundance of multiple enterobacterial genera. The use of LGG and antibiotics alleviated the depression-like behaviour and cognitive impairment of CEE-induced mice, reduced expression of inflammatory factors such as interleukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α in the ileum, serum and brain and increased the expression of synaptophysin (SYN), postsynaptic density protein-95 (PSD-95) and brain-derived neurotrophic factor (BDNF) in the hippocampus. Together, LGG can alleviate depression-like behaviour caused by CEE in mice while also improving cognitive and memory functions through reducing peripheral and nervous system inflammation factors and balancing gut microbiota.
Methods and apparatus providing a patient digital twin are disclosed. An example apparatus including an example patient digital twin includes a data structure created from a combination of patient electronic medical record data and historical information, the combination extracted from information system(s) and arranged in the data structure to form a digital representation of the patient. The example patient digital twin is arranged for query and simulation. The example patient digital twin is to receive feedback regarding the patient following a procedure conducted on the patient. The example patient digital twin is to incorporate the feedback into the patient digital twin when elements for the procedure have been completed. The example patient digital twin is to process the incorporated feedback to generate and output a recommendation for follow-up with respect to the patient based on the digital representation of the patient including the incorporated feedback with respect to the procedure conducted.
PURPOSE: To provide a novel anesthetic agent compsn. which consists of adenosine and adenine nucleotide as essential components, is useful for inducing anesthesia and analgesia with a normal blood pressure, has not toxicity and is fast in restoration from an anesthetic state. CONSTITUTION: This compsn. consists of drugs selected from the adenosine, adenosine phosphate, adenosine diphosphate and adenosine triphosphate as the effective components. The compsn. is preferably continuously and intravenously injected at a ratio of 50 to 500 μg/min per 1 kg body weight. The adenosine triphosphate is more preferable among the adenine nucleotides described above. The compsn. is recommended to be prepd. as an intravenous injection soln. by a method of dissolving the adenosine and the adenine nucleotides together with, for example, salt, sugar, pH control agent, excipients, such as thickener and assistants into a physiological salt soln.
The invention discloses a traditional Chinese medicine preparation for treating thyroiditis and a preparation method, and belongs to the field of traditional Chinese medicines. Effective components of the traditional Chinese medicine preparation comprise the following raw materials: dracocephalum heterophyllum benth, willow leaves, laver, cassia twigs, schisandra glaucescens diels, rice beans, hollyhock roots, swampy gentianopsis herbs, herbs of tibet lancea, twigs and bark of nauclea officinalis pierre, caulis et folium piperis hancei, Ilex pubescens, panacis majoris, obscured homalomena rhizomes, Chinese incarvilla herbs and Japanese mazus herbs. According to the traditional Chinese medicine preparation disclosed by the invention, the selected medicinal materials are appropriate in concerted application. The traditional Chinese medicine preparation conforms to theories of traditional Chinese medicine and pharmacy and modern medicines, has the efficacies of reducing swelling, easing a pain, clearing heat, removing toxicity, promoting blood circulation, reducing the swelling, and promoting qi circulation to relieve a pain, and is convenient to use, good in absorption effect and free from poor, toxic and side effects. Clinical verification shows that internal and external environment of bodies can be improved, so that various symptoms of thyroiditis are prevented and treated. The traditional Chinese medicine preparation is suitable for being popularized and applied for clinical treatment and nursing of thyroiditis.
BACKGROUND: High glucose levels are a primary cause of diabetes-associated cellular dysfunction and tissue damage. Muscles are the key insulin target organ and therefore, have a high level of sensitivity to hyperglycemia. Our previous study revealed that 20(S)-ginsenoside Rg3 (S-Rg3) is a monomer with a good myogenic differentiation effect in ginsenoside. Furthermore, it can alleviate dexamethasone-induced muscle atrophy by protecting mitochondrial function. However, whether S-Rg3 is effective for diabetic-induced muscle atrophy has not been reported.
PURPOSE: This study aimed to investigate the protective effect of S-Rg3 on diabetic-induced muscle atrophy.
METHODS: C2C12 myoblasts, Drosophila, and mice were used as model systems, and the protective effect of S-Rg3 on diabetes was evaluated by assessing the levels of glucose and lipids. Furthermore, H&E, toluidine blue, Giemsa, and immunofluorescence staining were performed to detect the effects of S-Rg3 on muscle atrophy and myogenic differentiation. Moreover, the effects of S-Rg3 on mitochondrial morphology and function were also evaluated by electron microscopy, flow cytometry, and Seahorse. In addition, the underlying pathways of S-Rg3 effects were detected by Western blot. The related inhibitors and gene mutations in Drosophila were used for validation.
RESULTS: The analysis of diabetic mice model fed with a high-fat diet (HFD) and high glucose (HG) revealed that in the injured C2C12 myoblasts, S-Rg3 treatment significantly reduced the levels of triglycerides and glucose. Furthermore, it promoted the differentiation of myoblasts and inhibited mitochondrial dysfunction. In the Drosophila HG and HFD diabetic model, S-Rg3 reduced triglyceride and trehalose levels, increased climbing distance values, promoted myoblasts differentiation, preserved mitochondrial function, and inhibited muscle atrophy. Mechanistically, the beneficial effects of S-Rg3 were at least partially associated with the phosphorylation of AMPK and FoxO3 together with the inhibition of Smad3 phosphorylation, this pathway was validated by the UAS-AMPKα-RNAi Drosophila model.
CONCLUSION: In summary, this study revealed mechanistic insights into how S-Rg3 protects against diabetes-associated muscle atrophy in cells, Drosophila, and mice.
As renal progenitor cells, parietal epithelial cells (PECs) have demonstrated multilineage differentiation potential in response to kidney injury. However, the function of exosomes derived from PECs has not been extensively explored. Immunofluorescent staining of Claudin-1 was used to identify primary PECs isolated from mouse glomeruli. Transmission electron microscopy, nanoparticle tracking analysis, and western blotting were used to characterize the properties of PECs-derived exosomes (PEC-Exo). The therapeutic role of PEC-Exo in tubulointerstitial fibrosis was investigated in the unilateral ureteral obstruction (UUO) mouse model and TGF-β1-stimulated HK-2 cells. High-throughput miRNA sequencing was employed to profile PEC-Exo miRNAs. One of the most enriched miRNAs in PEC-Exo was knocked down by transfecting miRNA inhibitor, and then we investigated whether this candidate miRNA was involved in PEC-Exo-mediated tubular repair. The primary PECs expressed Claudin-1, PEC-Exo was homing to obstructed kidney, and TGF-β1 induced HK-2 cells. PEC-Exo significantly alleviated renal inflammation and ameliorated tubular fibrosis both in vivo and in vitro. Mechanistically, let-7b-5p, highly enriched in PEC-Exo, downregulated the protein levels of transforming growth factor beta receptor 1(TGFβR1) and AT-Rich Interaction Domain 3A(ARID3a) in tubular epithelial cells (TECs), leading to the inhibition of p21 and p27 to restoring cell cycle. Furthermore, administration of let-7b-5p agomir mitigated renal fibrosis in vivo. Our findings demonstrated that PEC-derived exosomes significantly repressed the expression of TGFβR1 and ARID3a by delivering let-7b-5p, thereby alleviating renal fibrosis. This study provides novel insights into the role of PEC-Exo in the repair of kidney injury and new ideas for renal fibrosis intervention.
A composition for treating inflammation and pain, including an antiinflammatory/ anti-pain agent in combination with a hydrogen- generating compound. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A composition for treating inflammation and pain, including a drug that produces inflammation as an unwanted side effect in combination with a hydrogen-generating compound. A method of treating inflammation and pain, by administering an effective amount of the composition including an anti-inflammatory/anti-pain agent and a hydrogen-generating compound to an individual. A method of potentiating the response of an antiinflammatory/ anti-pain agent. A composition including a hydrogen-generating compound for reducing inflammation.