anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a Lactobacillus salivarius. The preservation number of the Lactobacillus salivarius is CGMCC No.6278. The invention also discloses an application of the Lactobacillus salivarius in fermentation generation of an extracellular polysaccharide, and a method for the fermentation generation of the extracellular polysaccharide. The method comprises the following steps: inoculating the Lactobacillus salivarius into a fermentation culturing medium under extracellular polysaccharide generation conditions, and fermenting to obtain a fermentation liquid. The invention further discloses the extracellular polysaccharide prepared through the method, and its application in the preparation of immunomodulators. The Lactobacillus salivarius can generate the extracellular polysaccharide, and the polysaccharide can well promote the activity of NK cells.
PURPOSE:An antitumor agent, containing an excited semiconductor as an active constituent, capable of acting on tumors to damage tumorous cells and preventing the multiplication and further achieving efficient antitumor effect. CONSTITUTION:An antitumor agent containing a semiconductor excited by X rays, ultraviolet rays, etc., as an active constituent. An inorganic semiconductor, particularly. TiO2, ZnS or SrTiO3 is preferably used as the semiconductor from the viewpoint of stability and influence on the body, etc. In administration, the agent is preferably used with a substance, e.g. hematoporphyrin or monoclonal antibody, etc. The excited semiconductor is capable of preventing the multiplication of the target tumorous cells and achieving efficient antitumor effect.
Mesoamerica is the center of origin of a great number of food crops that nowadays are part of a healthy diet. Pre-Columbian civilizations utilized more than 90% of these foods as ingredient or in main dishes, as well as for remedies and religious ceremonies. Since several years ago, Mesoamerican foods have been recognized by their outstanding concentration of bioactive compounds, including, phenolic compounds, pigments, essential fatty acids, amino acids, peptides, carbohydrates and vitamins, which provide a great number of health benefits. As a result of their unique composition, these ancient crops have several positive effects, such as hypoglycemic, antioxidant, anti-obesity, anti-inflammatory, anti-ageing, neuroprotective, anti-diarrheal, and anti-hypercholesterolemic capacity. Hence, this review is focused mainly in the anti-obesity and antioxidant potential of some of the most cultivated, harvested, as well as commercialized and consumed, food crops native of Mesoamerica, like, nopal and its fruit (Opuntia ficus indica spp.), chia (Salvia hispanica L.), pumpkin (Cucurbita spp.) and cacao (Theobroma cacao).
The invention provides an isolated T cell receptor, a modified cell, a coding nucleic acid and application thereof. The isolated T Cell Receptor (TCR) comprises at least one of an alpha chain and a beta chain, each comprising a variable region and a constant region, wherein the T cell receptor is capable of specifically recognizing an antigen Her2/neu expressed by a tumor cell, and wherein the amino acid sequence of the variable region of the alpha chain has at least 98% identity to the amino acid sequence set forth in SEQ ID No. 1, and wherein the amino acid sequence of the variable region of the beta chain has at least 98% identity to the amino acid sequence set forth in SEQ ID No. 2. The TCR can specifically recognize tumor antigens while avoiding possible off-target toxic side effects. The immune cells modified by the TCR have remarkable anti-tumor effect.
All patients were kept fasting after midnight and received midazolam 5 mg orally as premedication. All patients were premedicated with I.V. midazolam 0.03 mg/kg ten minutes before starting the operation. The anesthetic technique was standardized for all patients. All surgical procedures were performed by the same surgeon and consisted of arthroscopic removal of torn meniscus. Both intra-articular and intravenous solutions were prepared by an individual not involved in the study and the intra-articular drugs were injected by the surgeon (without knowing the contents). The anesthesiologist managing and monitoring the patient throughout the surgery provides IV drugs. No leg holder or tourniquet or surgical drain was used for any of the cases. After preparation and draping the patient's leg, patients were warned prior to each needle stick to decrease anxiety. All procedures were performed under complete aseptic conditions. Skin and subcutaneous tissues at each arthroscopic portal site were anesthetized with LA consisting of injection of a mixture of 2% lidocaine 5 mL with 1:200,000 epinephrine.

Care should be taken to avoid infiltration of the fat pad. It is a relatively aneural structure; as, too much local infiltration allows it to bulge out into the joint during the surgery. Flexion and extension of the knee joint several times help to spread of intra-articular solution and then waiting 20 minutes for anesthesia to take effect is helpful before the surgical incision.

The arthroscope was inserted into the knee, and inflow through the sheath was established. No pump was used for the saline inflow which was maintained through the arthroscope by the gravity. Gravity outflow drained through the superolateral portal. A separate egress cannula was used if indicated. The patient was encouraged to view the video monitor during the procedure. Constant verbal communication between the surgeon and the patient is important throughout the arthroscopic examination and surgery. This keeps the patient anxiety and muscle tension to the minimum which facilitates manipulation of the leg and thorough examination of the entire joint. Once finishing, instruments were removed and portals were closed with a 4-0 absorbable suture subcutaneously and steri-strips. A compression dressing was applied for three days to the knee.
Clavicle fractures account for 2% to 5% of all fractures in adults, with a majority of patients being young and active. A gold standard for the treatment of clavicle fractures has yet to be established, but single plated surgical intervention is most widely used. In recent years a smaller double plating technique has been described as a possible solution to the high removal rates associated with single plating. In (orthopaedic) surgery however, randomized controlled trials (RCTs) are recognized for their limitations. Although RCTs are considered the gold standard for testing the efficacy of new interventions, randomisation and blinding can be challenging. Simultaneously, there is an inclination for the usage of RCTs in clinical protocols, frequently based on the credo that it is the only valid method of comparing treatments. A natural experiment (NE), or quasi-experiments, in which groups are compared by nature of factors outside the control of the investigator (i.e. different surgical techniques between centres), offers a possible solution for methodological quality control. This study aims to increase the knowledge on surgical outcomes for single vs double plating in midshaft clavicle fractures following a natural experiment design.
PURPOSE:A nervous cell differentiation promoter, consisting of a herb medicine formula, i.e. SHOSAIKOTO GO KEISHIKA SHAKUYAKUTO containing Bupleuri Radix, Paeoniae Radix, Pinelliae Tuber, Cinnamomi Cortex, Zizyphi Fructus, Scutellariae Radix, Ginseng Radix, Glycyrrhizae Radix and Zingiberis Rhizoma, as a herbal medicine for epilepsy, enuresis, ulcerative colitis, etc., capable of acting on nervous cells and elongating the projections and useful for treating senile dementia, psychoneurotic disorder, etc. CONSTITUTION:A nervous cell differentiation promoter, obtained by decocting SHOSAIKO GO KEISHIKA SHAKUYAKUTO, i.e. 7g Bupleuri Radix, 6g Paeoniae Radix, 5g Pinelliae Tuber, 4g Cinnamomi Cortex, 4g Zizyphi Fructus, 3g Scutellariae Radix, 3g Ginseng Radix, 2g Glycyrrhizae Radix and 1g Zingiberis Rhizoma in 600ml water to give 350ml, taking out the residuum and used by administering the resultant extract in divided three portions. A Chinese medicinal extract agent made therefrom may be used. The above-mentioned promoter is capable of acting on the nervous cells to elongate nervous projections and has remarkable nervous cell differentiation promoting action with high safety. The promotor can be used for treating senile dementia, cerebrovascular disorder dementia, psychoneurotic disorder, parkisonism, autonomic imbalance, etc.
Individuals randomly assigned to the control arm where they brushed their teeth with a popular toothpaste (crest) in the morning and before bed. This routine was repeated daily for 4 weeks.
Early goal-directed fluid therapy (EGDT) had been regarded as an important fluid therapy strategy in early sepsis or septic shock patients. In recent years, several randomized control studies showed the EGDT therapy cannot make a better outcome in sepsis patients compared to the standard therapy. A strategy of controlled fluid resuscitation had showed good outcome in critical illness such as severe acute pancreatitis, major trauma. But many aspects of the so-called controlled fluid resuscitation remained controversial. In a previous study on severe acute pancreatitis, we described a bundle of controlled fluid resuscitation which had showed an ideal result with higher survival rate. So, we are going to use the bundle on sepsis patients, and to see if it can bring a better out come in sepsis patients compared to the EGDT strategy. This study aims to determine a better strategy of fluid resuscitation in sepsis patients
Adipose tissue metabolism is actively involved in the regulation of energy balance. Adipose-derived stem cells (ASCs) play a critical role in maintaining adipose tissue function through their differentiation into mature adipocytes (Ad). This study aimed to investigate the impact of an obesogenic environment on the epigenetic landscape of ASCs and its impact on adipocyte differentiation and its metabolic consequences. Our results showed that ASCs from rats on a high-fat sucrose (HFS) diet displayed reduced adipogenic capacity, increased fat accumulation, and formed larger adipocytes than the control (C) group. Mitochondrial analysis revealed heightened activity in undifferentiated ASC-HFS but decreased respiratory and glycolytic capacity in mature adipocytes. The HFS diet significantly altered the H3K4me3 profile in ASCs on genes related to adipogenesis, mitochondrial function, inflammation, and immunomodulation. After differentiation, adipocytes retained H3K4me3 alterations, confirming the upregulation of genes associated with inflammatory and immunomodulatory pathways. RNA-seq confirmed the upregulation of genes associated with inflammatory and immunomodulatory pathways in adipocytes. Overall, the HFS diet induced significant epigenetic and transcriptomic changes in ASCs, impairing differentiation and causing dysfunctional adipocyte formation.NEW & NOTEWORTHY Obesity is associated with the development of chronic diseases like metabolic syndrome and type 2 diabetes, and adipose tissue plays a crucial role. In a rat model, our study reveals how an obesogenic environment primes adipocyte precursor cells, leading to epigenetic changes that affect inflammation, adipogenesis, and mitochondrial activity after differentiation. We highlight the importance of histone modifications, especially the trimethylation of histone H3 to lysine 4 (H3K4me3), showing its influence on adipocyte expression profiles.
The present invention relates to a livestock A type and O type foot-and-mouth disease virus bivalent DNA vaccine. Coding regions of a VP1 proteantigen determinant part of an A type and O type foot-and-mouth disease virus strain are connected in series and connected with a DNA segment capable of improving the immunogenicity of the foot-and-mouth disease virus strain. After being incised in an enzyme mode, the segment is connected with a eukaryotic expression vector to convert escherichia coli competent cells; a positive clone is obtained through PCR identification; the positive clone is treated through culture, thallus collection, bacterium cracking and centrifugation; supernatant is filtered, centrifugated and washed; precipitates are dissolved in a buffer solution, LiCl is added and centrifugated, the supernatant is removed and washed with ethanol, and precipitated DNA is dissolved with Tris-EDTA containing RNAase; NaCl is added to collect DNA precipitates after centrifugation, and the DNA precipitates are extracted after being dissolved in TE; ammonium acetate and ethanol are added into a water phase and centrifugated to remove supernatant, and the supernatant is washed with ethanol. The vaccine belongs to an A type and O type bivalent vaccine, and an antibody resisting an A type foot-and-mouth disease virus and an antibody resisting an O type foot-and-mouth disease virus can be simultaneously generated after animals are immunized. The vaccine does not perform the action of pathogenicity possibly caused by an attenuated vaccine and an inactivated vaccine. The present invention has the advantages of high yield, stability, persistent effects, and convenient storage and transportation. The vaccine induces an organism to generate a comprehensive immune response; the vaccine can express a modified natural antigen.
Although there is much evidence showing age-related reduction of cognitive function, many researchers point out a more optimistic viewpoint that aging is not a progressive loss. By remodeling the lifestyle, or/and monitoring the physical factors, the risk to develop dementia could be reduced. The above statements are mostly based on the epidemiological research, while it remains unclear how the aging modulates the brain changes. In previous study, the investigators have found that individuals with subjective memory complaint (SMC) showed altered brain changes in terms of resting-state connectivity when compared to those without SMC. The present study further aims to examine whether the brain function is affected by the past life experiences, such as lifestyle and physiology-related factors in SMC. More importantly, this study aims to clarify whether the lifestyle remodeling could improve SMC's cognitive function and modulate the reactivity of inflammatory factors, leading to significantly slow down the disease progression to MCI or dementia.

In summary, the present study aims to understand how the lifestyle remodeling affects SMC's brain function and biochemical indicators. Before and after the intervention, this study will use neuropsychological tests to assess all the aspects of cognitive functions, use Electroencephalogram to investigate the brain activation patterns, and use biochemical analyses to quantify the reactivity of inflammation, toxic as well as neurotrophic factors. Through the follow-up design, this study also plan to investigate the lasting duration of the intervention and the how the neural reorganization occurs as function of time.
Subjects will be randomized into one of four groups, four, eight, ten or twelve sessions. Sessions will be con-ducted weekly by Telehealth and will be modified based on the duration of treatment but all will include the following, evaluation and orientation; data acquisition and delivery of sleep restriction therapy \& stimulus control instructions; review of sleep hygiene; cognitive therapy \[decatastrophization\]; managing non-adherence and relapse prevention), and, finally, the final sessions will be largely focused on time-in-bed titration. Treatment will be conducted by a master therapist via a HIPAA compliant video link.

All CBT-I related data will be obtained via dedicated internet websites built with RedCap, where subjects will be asked to complete weekly and monthly questionnaires. One website will be for use by subjects. One website will be for use by the therapist. The patient and therapist website will have a landing page (password entry), a login page, and an activities page (what questionnaires are due when). For an example of such a website, please see our pilot study, https://redcap.med.upenn.edu/surveys/?s=RXLLA7C4KJ (access using password "sleepstudy"). The patient website will contain daily sleep diaries, weekly severity measures of insomnia (ISI), sleepiness (ESS), fatigue (PROMIS 7a, Brief Fatigue Inventory, and FACIT-F), depression (PHQ-9), anxiety (GAD-7), a medical symptoms checklist.
Participants who have not progressed while receiving vismodegib will receive pembrolizumab IV over 30 minutes on day 1 and take vismodegib 150 mg by mouth daily. Cycles repeat every 21 days for up to 24 months in the absence of disease progression or unacceptable toxicity.
Guangdong Provincial People's Hospital will be the lead center, with an additional 12 hospitals designated as satellite centers for the study. To sum up, these centers will recruit a total of 140 consenting patients. Following informed consent and baseline testing, the participants will be randomized in a 1:1 fashion to receive a 6-week progressive, comprehensive exercise training and inspiratory muscle training or attention control.

The intervention group will receive an 6-week exercise program consisting of endurance, resistance, balance, mobility, and inspiratory muscle training. The comprehensive rehabilitation will begin during the patient's stay and continue to the outpatient clinic. The control group will receive usual care with bi-weekly contact from study personnel. The primary outcomes of the study are improvements in the summary score of KCCQ and PImax%pred, while secondary endpoints include the impact on physical function, cardiac function, psychological status, and major adverse cardiovascular events (MACE). Additionally, the study will also explore the effects of comprehensive rehabilitation on hospital readmission and mortality rates, with follow-up assessments planned up to 6 months after discharge.
The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.
AIM: This qualitative study aimed to explore the experiences of participants who were enrolled in 6-month controlled weight loss interventions with 2-month follow-up to better understand the process of behaviour change and maintenance.
METHODS: Fifteen participants who completed or dropped out from either a daily energy restriction or intermittent fasting group were recruited using maximum variation purposive sampling. In-depth, semi-structured interviews were conducted at the 2-month follow-up phase. All interviews were transcribed and analysed using thematic analysis, guided by behaviour change models including transtheoretical model, social cognitive theory and integrated model of change.
RESULTS: Participants following both diets showed similar behaviour change patterns. Their first motivations were mostly external and relied on 'accountability' to adhere to the diet when initiating the dietary changes. Participants highlighted the importance of frequent reviews and monitoring in assisting their adherence. This feedback system promoted the development of self-efficacy and internalised motivation to encourage an 'ownership'. Participants who transitioned successfully from relying on accountability to take 'ownership' of the intervention were more capable of tackling challenges and tailoring their diet to form a new routine for long-term maintenance.
CONCLUSION: External motivations were key to initiate while internalised motivations were more important to sustain the behaviour change. Health professionals can assist this process through routine monitoring and feedback processes in clinical practice.
Hydrocephalus patients planned for shunting surgery. They will undergo clinical and imaging examinations at day 1, 3 months and 1 year after their surgery.
This group will receive an open-label placebo. The manual treatment will be performed in the same areas of the active comparator but using a very light pressure. Additionally, before the start of the treatment, Four treatments will be provided at 1, 2, 4 and 8 weeks.
A production method for making powder cosmetics having improved characteristics. The method includes mixing a powder component and an oil component as a binder using a mixing apparatus. The mixing apparatus is a facing rotor type mixing apparatus having a first rotor with a plurality of blades and a second rotor with a plurality of blades in a mixing chamber. The first rotor and the second rotor face each other and have rotating shafts on the same axis line. In the facing rotor type mixing apparatus, raw materials are fed into an introduction opening on a first rotor side. The raw materials are mixed by rotating the first rotor and the second rotor in the same or opposite directions to each other, and the mixed raw materials are discharged from a discharge opening on a second rotor side.
PURPOSE: A personal health management method and a device thereof are provided to supply high security for health devices in an environment including both the health devices and non-health devices using the same protocol. CONSTITUTION: If a communication device and a communication link are set according to a first communication protocol, a control unit (602) determines whether the communication device needs higher security. If the communication device is a health device, the control unit executes health security algorithm. The health security algorithm provides higher security than security algorithm applied to the first communication protocol. The control unit communicates with the health device by using the health security algorithm. [Reference numerals] (602) Control unit; (604) WiFi transmitter/receiver unit; (606) Memory
This trial will have one screening visit with tests to assess if subjects are eligible to start study therapy. Once subjects have completed screening, and if they are determined to be eligible, they will be randomized to receive one of three oral daily doses of LUM-201 or daily injections of recombinant human growth hormone (rhGH). All subjects will have an equal chance of being placed in any of the four groups.

The trial consists of up to 24 months of treatment. After screening, subjects will return to the clinic for 6 (subjects placed in rhGH group) or 10 visits (subjects placed in LUM-201 group). During several of these clinic visits, subjects will have a physical exam, blood, and urine collections. There will also be 3 phone calls with study staff that will take place between the clinic visits.
Participants assigned to oral sodium bicarbonate will receive 0.5 mEq/kg-lean body weight (LBW)/day for the entire 12 months. Participants will take ½ the daily dose in the morning and the other ½ in the evening. The number of capsules will be rounded to the nearest whole capsule. To reduce pill burden and increase compliance the maximum number of pills per day will be six.