anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study evaluates whether random forest (RF) models are as effective as traditional Logistic Regression (LR) models in predicting multidrug-resistant Gram-negative bacterial nosocomial infections. Data were collected from 541 patients with hospital-acquired Gram-negative bacterial infections at two tertiary-level hospitals in Urumqi, Xinjiang, China, from August 2022 to November 2023. Relevant literature informed the selection of significant predictors based on patients' pre-infection clinical information and medication history. The data were split into a training set of 379 cases and a validation set of 162 cases, adhering to a 7:3 ratio. Both RF and LR models were developed using the training set and subsequently evaluated on the validation set. The LR model achieved an accuracy of 84.57%, sensitivity of 82.89%, specificity of 80.10%, positive predictive value of 84%, negative predictive value of 85.06%, and a Yoden index of 0.69. In contrast, the RF model demonstrated superior performance with an accuracy of 89.51%, sensitivity of 90.79%, specificity of 88.37%, positive predictive value of 87.34%, negative predictive value of 91.57%, and a Yoden index of 0.79. Receiver operating characteristic curve analysis revealed an area under the curve of 0.91 for the LR model and 0.94 for the RF model. These findings indicate that the RF model surpasses the LR model in specificity, sensitivity, and accuracy in predicting hospital-acquired multidrug-resistant Gram-negative infections, showcasing its greater potential for clinical application.
WBM smart insole system is a product that can monitor the pressure under the foot and provide live feedback (if this option activated) to the user in case of exceeding the specified limits. Its components are insole with pressure sensors and mobile applications (IOS, Android). Post-operative patients (osteochondral lesion of the talus) will be monitored with the WBM smart insole system in case live feedback is turned on. We aimed to ensure the compliance of patients to specified weight bearing limits. We will follow up this grup for 6 weeks periods with WBM smart insole system. Pre-op. and post-op 6 week, we evaluate the patients in case of ankle function, pain with The American Orthopaedic Foot \& Ankle Society (AOFAS) Scoring. Also we will monitor the compliance success of patients with WBM smart insole system during 6 week. The relationship with compliance to weight bearing success and AOFAS scores will be evaluate.
RASopathies represent a distinct class of neurodevelopmental syndromes caused by germline variants in the Ras/MAPK pathways. Recently, a novel disease-gene association was implicated in MAPK kinase kinase kinase 4 (MAP4K4), which regulates the upstream signals of the MAPK pathways. However, to our knowledge, only two studies have reported the genotype-phenotype relationships in the MAP4K4-related disorder. This study reports on a Korean boy harboring a novel de novo missense variant in MAP4K4 (NM_001242559:c.569G>T, p.Gly190Val), revealed by trio exome sequencing, and located in the hotspot of the protein kinase domain. The patient exhibited various clinical features, including craniofacial dysmorphism, language delay, congenital heart defects, genitourinary anomalies, and sagittal craniosynostosis. Our study expands the phenotypic association of the MAP4K4-related disorder to include syndromic craniosynostosis, thereby providing further insights into the role of the RAS/MAPK pathways in the development of premature fusion of calvarial sutures.
Participants will receive TV-46046 placebo (0.3 mL) SC injection in a crossover design with the other 3 SC study drug injections. The 4 study drug injections will be administered approximately 1 hour apart.
The present invention discloses a medicine for treating diabetic nephropathy. The medicine is prepared from seven traditional Chinese medicinal materials of astragalus root, rhizoma polygonati, dogwood fruit, leech, rhubarb sauted with wine, hemlock parsley and achyranthes. The present invention also discloses a preparation method of the medicine. The medicine has the effects for benefiting qi, activating blood circulation, nourishing yin and invigorating the kidney and mainly treats diabetes with deficiency of both vital energy and yin and venation stasis. The medicine is suitable for the symptoms of dim complexion, tiredness, weakness, shortness of breath, unwillingness to speak, spontaneous sweat or night sweat, thirst, desire for drinking, dysphoria with feverish sensation in chest, dry bound stool, dark tongue quality or petechia, ecchymosis, dark purple sublingual bluish tendons, engorgement of the sublingual bluish tendons, and fine and unsmooth pulse. The medicine is suitable for patients with diabetic nephropathy with the symptoms and has the advantages of quick action, obvious effect and no adverse reaction after clinical trial.
This is a 6-month open label pilot RCT that will be conducted on Lebanese subjects with obesity, upon the initiation of Semaglutide for medical weight management, as recommended by their physician. Patients will be randomized to 2 treatment arms: Med diet and HP/LC diet. Med diet will be hypocaloric, allowing the same energy restriction, of 500 Kcal/d, while the HP/LC diet will be ad libitum. Participants will be recruited from the Endocrine clinics at AUB-MC, and from satellite clinic next in Beirut. Brochures and posters of the trial will be available in the clinic waiting areas. Patients of both participating and non-participating physicians will be recruited in the study.
The invention discloses a tissue pathology picture classification method based on a picture Bert, which relates to the classification problem of normal and abnormal tissue slices in tissue pathology detection. The depth neural network is used for classifying the tissue pathology pictures, so that the workload of a pathologist can be effectively reduced, and the accuracy and efficiency of diagnosis are improved. Abnormal tissue classification depends on local and global characteristics of tissue slices, and a traditional image classification network is limited by the size and the computing power of a model, can only process smaller images, and is difficult to classify by combining the global characteristics. Meanwhile, when training the classification model, a large amount of labeling data is needed, and the data acquisition is difficult. Aiming at the problems, a histopathological picture classification method based on the picture Bert is provided. The test result shows that the method can effectively utilize the non-labeling information to train and combine the global features to encode the small images, thereby effectively improving the classification effect. The method is mainly applied to tissue pathology picture classification.
Due to activation of humoral and cellular immunity following ZOLGENSMA infusion, patients with underlying active infection, either acute (e.g., respiratory, gastrointestinal) or chronic uncontrolled (e.g., chronic active hepatitis B), could be at an increased risk of serious systemic immune response, potentially resulting in more severe clinical courses of the infection. Serious systemic immune response can present with a variety of findings (e.g., high fever, hypotension, etc.). Patients with infection were excluded from participation in ZOLGENSMA clinical trials. Recommend increased vigilance in the prevention, monitoring, and management of infection before and after ZOLGENSMA infusion.

To mitigate the risk of serious and life-threatening systemic immune response, administer ZOLGENSMA to patients who are clinically stable in their overall baseline health status (e.g., hydration and nutritional status, absence of infection) prior to infusion. Postpone ZOLGENSMA in patients with infections until the infection has resolved and the patient is clinically stable. Clinical signs or symptoms of infection should not be evident at the time of ZOLGENSMA infusion [see Dosage and Administration (2.1)]. Recommend seasonal prophylaxis against influenza and respiratory syncytial virus (RSV) and vaccination status should be up-to-date prior to ZOLGENSMA administration.
Patients' incisions are completed using the unipolar diathermy from Whiteline until we reach the parietal peritoneum (cutting the Whiteline then coagulating until reaching the peritoneum). The used diathermy frequency was 50-70 MHz.
The invention relates to particles for determining the local temperature in organic and non-organic bodies. The temperature is determined using nuclear magnetic resonance spectroscopy (NMR) when the particles are utilized. The aim of the invention is to provide temperature sensors which allow the temperature to be measured in vivo in a contactless manner on a nanometer scale while making it possible to use NMR-active substances which are foreign to the body or are contained therein in small quantities only and can be toxic, the temperature sensors allowing the temperature to be measured in vivo also on materials that are foreign to the body, e.g. nanoparticles that are heated in the body in a certain way. Another aim of the invention is to produce the temperature sensors with defined geometrical dimensions in the nanometer range. The aims are achieved by means of particles which contain a filling of one or several temperature-sensitive substances in a shell, the temperature of the substances being measurable in vivo using NMR. The shell is composed of one or several carbon nanotubes that are inserted into one another or a fullerene. Elementary metals, paramagnetic substances, materials having a magnetic order, substances having grid effects, molecular systems, and/or heterogeneous systems are selected as temperature-sensitive substances provided that the same have specific physical-chemical properties which are influenced by changes in temperature and the change in the properties of the same can be measured using NMR.
Large doses of caffeine may produce headache, excitement, agitation, a condition resembling anxiety neurosis, scintillating scotoma, hyperesthesia, tinnitus, muscle tremors or twitches, diuresis, tachycardia, extrasystoles, and other cardiac arrhythmias. Further CNS depression may occur when already depressed patients are too vigorously treated with Caffeine and Sodium Benzoate Injection.

Caffeine and other xanthines may enhance the cardiac inotropic effects of ß-adrenergic stimulating agents. Caffeine has also been reported to increase its own metabolism and that of other drugs, including phenobarbital and aspirin. Caffeine produces false-positive elevations of serum urate as measured by the Bittner method. The drug also produces slight increases in urine levels of vanilamandelic acid (VMA), catecholamines, and 5-hydrocyindoleacetic acid. Because high urine levels of VMA or catecholamines may result in false-positive diagnosis of pheochromocytoma or neuroblastoma, caffeine intake should be avoided during tests for these disorders.
Chronic lateral epicondylitis is defined as the presence of a "tennis elbow" for more than 3 months. It is a common condition in the general population and often results in long-term sick-leave. The etiology is unknown. A large number of treatments have been tried but none is generally accepted. However, in Achilles tendinitis a new treatment has been shown effective. It consists of eccentric exercise, i.e. work during stretching rather than shortening of the muscle (concentric exercise). The latter is currently the most common treatment method.

This project is a randomised controlled clinical trial of eccentric versus concentric exercise in 205 patients with chronic lateral epicondylitis. Pain and muscle strength were recorded at start of treatment and after 1,2,3,6 and 12 months. Activities of daily life (ADL) and well-being were recorded at start of treatment and after 3, 6 and 12 months. In addition, blood specimens for a number of neural peptides have been sampled. Moreover, the involvement of the peripheral nervous system in the elbow area has been examined in a subsample of patients. A biopsy from 20 patients per treatment group and from 20 healthy subjects, and a positron emission tomography (PET) scan of 23 patients were performed to allow qualitative and quantitative examination of neural fibres, peptides and receptors. The health economy of the two treatments will be investigated using data from this project and from available registers.
BACKGROUND: Clinico-anatomical review and pilot studies demonstrated that intraparenchymal injection at any site, even those not containing the index lesion, or periareolar injections should provide concordant outcomes to peritumoral injections.
METHOD: This was a single-center retrospective cohort at King Chulalongkorn Memorial Hospital. The electronic medical records of patients were characterized into conventional and new injection concept groups. The inclusion criteria were patients who had either a mastectomy or BCS along with SLNB. We excluded patients who underwent ALND, received neoadjuvant therapy, or had non-invasive breast cancer. The primary outcome was the 5-year rate of breast cancer regional recurrence. Additionally, we reported on the re-operation rate, disease-free period, distant disease-free period, mortality rate, and recurrence rates both locoregional and systemic. Recurrences were identified through clinical assessments and imaging.
SURGICAL TECHNIQUE: 3 ml of 1%isosulfan blue dye was injected, with the injection site varying according to the specific concept being applied. In cases of SSM and NSM following the new concept, the blue dye was injected at non-periareolar and non-peritumoral sites. After the injection, a 10-minute interval was observed without massaging the injection site. Following this interval, an incision was made to access the SLNs, which were subsequently identified, excised, and sent for either frozen section analysis or permanent section examination.
RESULT: There were no significant differences in DFS, DDFS or BCSS between the two groups (p = 0.832, 0.712, 0.157). Although the re-operation rate in the NI group was approximately half that of the CI group, this difference was not statistically significant (p = 0.355).
CONCLUSION: Our study suggests that tailoring isosulfan blue dye injection site based on operation type rather than tumor location is safe and effective approach for SLN localization in early-stage breast cancer. However, this study has limitations, including being a single-center study with low recurrence and death cases. Future studies should aim to increase the sample size and follow-up period.
Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by chronic airway inflammation. A Japanese herbal medicine, hochuekkito (TJ-41), is prominently used for chronic inflammatory diseases in Japan. This study aimed to analyze the anti-inflammatory effect of TJ-41 in vivo and its underlying mechanisms. We created a COPD mouse model using intratracheal administration of porcine pancreatic elastase and lipopolysaccharide (LPS) and analyzed them with and without TJ-41 administration. A TJ-41-containing diet reduced inflammatory cell infiltration of the lungs in the acute and chronic phases and body weight loss in the acute phase. In vitro experiments revealed that TJ-41 treatment suppressed the LPS-induced inflammatory cytokines in BEAS-2B cells. Furthermore, TJ-41 administration activated the AMP-activated protein kinase (AMPK) pathway and inhibited the mechanistic target of the rapamycin (mTOR) pathway, both in cellular and mouse experiments. We concluded that TJ-41 administration reduced airway inflammation in the COPD mouse model, which might be regulated by the activated AMPK pathway, and inhibited the mTOR pathway.
In 1976, the NHS I enrolled 121,700 female nurses ages 30 to 55 years who returned a mailed questionnaire regarding their medical history and lifestyle.85,86 There were no exclusions by race; 95% were white reflecting the racial make-up of nurses at that time. Participants receive follow-up questionnaires biennially to record newly diagnosed illnesses and to update lifestyle factors and every 4 years received semiquantitative food frequency questionnaires (FFQs).87 The questionnaires (available at https://nurseshealthstudy.org/participants/questionnaires) are administered every other year, and the 40-year follow-up exceeds 90% of eligible person-time. Information on history of HZ and the date at which HZ occurred was collected on the 2000, 2004, 2008, 2012, 2019, 2021 and 2023 biennial questionnaires. The 2021 and 2023 questionnaires also collected information on whether participants had been vaccinated against HZ and the date of vaccination.
The invention discloses a Jiakang Ling tablet for hyperthyroidism and the processing technique thereof. The Jiakang Ling tablets mainly comprises components with the following weight percentages: 10.0 to 18.0 parts of yeradetajo, 10.0 to 18.0 parts of red sage root, 10.0 to 18.0 parts of selfheal, 10.0 to 18.0 parts of jam, 15.0 to 35.0 parts of calcined fossil fragment and 15.0 to 35.0 parts of calcined oyster shells. The invention analyzes with the traditional Chinese medicine theory. According to the invasion mechanism of the yin deficiency of liver and kidney and the over active yang energy of the hyperthyroidism disease, the invention takes the liver calming and yang subduing and the hard masses softening and resolving as the basic therapeutic principle, can significantly reduce the TT3 and TT4 content of serum, improve the organism celluar immunologic function and the sign immunologic function, and inhibit the excretion of thyroid to lead the unbalanced incretion metabolized system to be stabilized, thereby achieving the purpose of the treatment of hyperthyroidism. The invention is appliance to the hyperthyroidism with the symptoms of heart palpitation, colliquative sweating, anxiety and irritability, dryness of the throat, and rapid pulse, etc. The invention is the pure Chinese traditional medicine preparation, the obvious adverse effect on the hemopoietic system and the liver and kidney function is not observed, the invention is appliance to patients who can not take the thiourea antithyroid drug because the granular leudocytes decreases, and can be used as the treatment medicine of the gentle hyperthyroidism patients and the adjuvant of the moderate and severe hyperthyroidism patients.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, oncology, and can be used for treatment of locally extended rectal cancer. For this purpose in preoperative period the tumor is affected with distance-type gamma-irradiation with single focal dose of 5 Gy, at dose ionization maximum of 100 cGy/min. The course of radiation treatment is 5 days. Thus in 1st, 3d and 5th days of radiation treatment 3-4 hours prior to irradiation a composite mixture of: (wt %) sodium alginate 46; 5-fluorouracil - 0.5; distilled water up to 100 ml is intrarectally administered. ^ EFFECT: method enables to improve immediate and long-term results of treatment, to reduce possibility and severity of early and late radiation reactions of organs and tissues within the irradiation field, to reduce total and hematologic toxicity. ^ 1 ex
PURPOSE: To obtain a self-adhesive matrix system to be used for continuous percutaneous release of piribedil so that the medicine can permeate through a skin with an enough diffusion rate to obtain the plasma level satisfying the therapeutic requirements without giving adverse influences on the skin or without inducing irridiation, allergy or sensitization. CONSTITUTION: This matrix system is produced in the following processes. An ethylene/vinylacetate copolymer is dissolved in dichloromethane. Oleic acid is separately added to ultrafinely pulverized piribedil and subjected to ultrasonic mixing. This obtd. soln. is mixed to the dissolved polymer above described. Then, an acryl-based adhesive is added to the mixture, and the obtd. material is applied on an occlusive polyethylene/aluminum supporting film by using a spreader. Then the solvent in the laminated body is evaporated to form a matrix structure. Then, a peelable polyester protective film is applied on the crosslinked adhesive system and the obtd. self-adhesive matrix is cut to obtain the objective percutaneous device containing the effective component in an amt. equal to 5% of the whole mass.
The invention provides a vaccine immunologic adjuvant, a vaccine prepared by using the vaccine immunologic adjuvant and a preparation method of the vaccine. The vaccine immunological adjuvant comprises human ferritin or a human ferritin mutant, and the specific sequence comprises any one of amino acid sequences shown as (I), (II) or (III): (I) an amino acid sequence shown as SEQ ID NO. 1; (II) an amino acid sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID No. 1; (III) an amino acid sequence obtained by modifying, substituting, adding or deleting one or more amino acids in the amino acid sequence shown in SEQ ID NO. 1. The vaccine immunologic adjuvant can be injected for use, can simultaneously cause humoral immunity and cellular immunity, has the characteristics of quick, lasting and high-efficiency immunity, and is an excellent protein general vaccine immunopotentiator.
The invention provides rBCG (Bacillus Calmette-Guerin) expressing Brucella melitensis P39 gene. The rBCG is constructed by transferring an expression vector carrying a codon-optimized Brucella melitensis P39 gene into BCG. The cytoplasmic binding protein PBP39 (P39 as a coding gene) produced by Brucella is a T-cell antigen. BCG is the only commercial vaccine for preventing tuberculosis so far. Research proves that BCG not only has a remarkable immunoadjuvant effect, but also is an exogenous gene expression host with good performance and high safety. BCG can increase the expression quantity of the P39 gene when used for expressing the codon-optimized Brucella melitensis P39 gene, further, the constructed rBCG vaccine can simulate intracellular infection and parasitic features of Brucella and induce the organism to produce immune response more effectively, the advantages including high safety, simple preparation, low cost and the like of BCG as an expression host as well as the immunoadjuvant effect of BCG can be further realized, and rBCG is expected to be a novel vaccine for Brucella.
Cabozantinib maintenance 60 mg daily for 2 years or until withdrawal criterion After documented disease progression (according to RECIST 1.1), the treatment will be unblinded. Subjects receiving cabozantinib shall be further treated at the investigator discretion.
The purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol. The study includes 30 healthy patients whose socio-demographic and descriptive characteristics are held. The changes in the dynamic and static position of foot were measured by pedobarography whereas the level of fatigue was measured by Borg Fatigue Scale. The variables were investigated using Shapiro-Wilk's test to determine the normality. The student's t-test for paired samples were used to analyse, means (X), standard deviations (SD), 95% confidence intervals (95%CI), mean difference and Cohen's d-effect size were calculated. The significance level was set at .05. The effect size was considered 'small' if d= .20; 'medium' if .d=.5; 'large' if d= .8.