anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Making a treatment decision for female stress urinary incontinence (SUI) can be challenging for patients and healthcare providers. Dutch guidelines advise to counsel both pelvic floor muscle therapy and midurethral sling surgery as primary treatment options in uncomplicated moderate to severe cases. The use of a patient decision aid (PDA) can support decision-making, reduce decisional conflict and decisional regret, and increase knowledge. The aim of this study was to develop and evaluate an online PDA for females (SUI).
METHODS: This mixed-methods study was performed in consecutive stages by a multidisciplinary working group. PDA design was based on the International Patient Decision Aids Standards (IPDAS) and on outcomes of needs assessments amongst patients and healthcare providers. Content was based on Dutch guidelines, targeted literature searches and patient information from the Dutch scientific society for gynecology. The concept version was evaluated by patients, patients' advocates, and healthcare providers.
RESULTS: Using the nominal group technique, the working group established the design and format of the PDA. Fifty-six out of 58 applicable items of the IPDAS were met. The PDA contains information on the condition, advice on lifestyle adaptations, and describes surgical and nonsurgical treatment options. The option grid contains comparisons of the primary treatment options. Furthermore, value clarification exercises and narratives were included. Acceptability and usability evaluation of the concept version was performed by 15 healthcare providers, three patients, and two patients' advocates. Comments were processed in the working group, resulting in the final version of the PDA, which was supported by all assessors.
CONCLUSION: Our multidisciplinary working group developed an online PDA for women with moderate to severe SUI including conservative and surgical treatment options, based on IPDAS criteria, guidelines, scientific evidence, and needs assessments from patients and healthcare providers. This PDA is supported by patients, healthcare providers, scientific societies, and the Dutch patients' association. The next step is to evaluate and implement this PDA in daily practice.
TRIAL REGISTRATION: ID 2014-308.
Risk Summary

Limited case reports of treprostinil use in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes. However, there are risks to the mother and the fetus associated with pulmonary arterial hypertension (see Clinical Considerations). In animal studies, no adverse reproductive and developmental effects were seen for treprostinil at ≥8 and ≥134 times the human exposure when based on Cmax and AUC, respectively, following a single, inhaled 64 mcg dose of treprostinil inhalation powder.

The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.

Clinical Considerations

Disease-associated maternal and embryo-fetal risk

Pulmonary arterial hypertension is associated with an increased risk of maternal and fetal mortality.

Data

Animal reproduction studies have been conducted with treprostinil via continuous subcutaneous administration and with treprostinil diolamine administered orally. In studies with orally administered treprostinil diolamine, no adverse effect doses for fetal viability/growth, fetal development (teratogenicity), and postnatal development were determined in rats. In pregnant rats, no evidence of harm to the fetus was observed following oral administration of treprostinil diolamine at the highest dose tested (20 mg/kg/day), which represents about 129 and 1366 times the human exposure, when based on Cmax and AUC, respectively, following a single, inhaled 64 mcg dose of treprostinil inhalation powder. In pregnant rabbits, external fetal and soft tissue malformations and fetal skeletal malformation occurred. The dose at which no adverse effects were seen (0.5 mg/kg/day) represents about 8 and 134 times the human exposure, when based on Cmax and AUC, respectively, following a single, inhaled 64 mcg dose of treprostinil inhalation powder. No treprostinil treatment-related effects on labor and delivery were seen in animal studies. Animal reproduction studies are not always predictive of human response.
The active ingredient in Famotidine Tablets, USP is a histamine-2 (H2) receptor antagonist. Famotidine is N'-(aminosulfonyI)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio] propanimidamide. The molecular formula of famotidine is C8H15N7O2S3 and its molecular weight is 337.43. Its structural formula is:

Each famotidine tablet for oral administration contains either 20 mg or 40 mg of famotidine USP and the following inactive ingredients: colloidal silicon dioxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sodium starch glycolate, talc, and titanium dioxide. In addition the 20 mg tablets contain ferric oxide red and ferric oxide yellow.

Famotidine, USP is a white to pale yellowish white crystalline powder that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol.

Meets USP Dissolution Test 2
PURPOSE:To provide the subject composition capable of preventing the hair from damage, causing no decline in the physical properties of hair and feeling touch, containing, as active ingredients, a reductive or oxidative substance and a modified silicone derivative. CONSTITUTION:The objective composition contains, as active ingredients, (A) 0.01-50wt.% of a reductive or oxidative substance and (B) 0.1-25wt.% of a modified silicone derivative having melting point of >=30 deg.C at least one alkoxy group in the molecule. This composition can be prepared into a form such as a cream emulsion by conventional means. The component B is e.g. a stearoxy-modified silicone. Treatment with an agent containing this composition can give good hair combability with easy hair style trimming and also sustainedly give favorable hair touch with wiriness and luster when finished.
Colorectal cancer (CRC), a major global health concern, may be influenced by dietary protein digestibility impacting gut microbiota and metabolites, which is crucial for cancer therapy effectiveness. This study explored the effects of a casein protein diet (CTL) versus a free amino acid (FAA)-based diet on CRC progression, gut microbiota, and metabolites using carcinogen-induced (AOM/DSS) and spontaneous genetically induced (ApcMin/+ mice) CRC mouse models. Comprehensive approaches including 16s rRNA gene sequencing, transcriptomics, metabolomics, and immunohistochemistry were utilized. We found that the FAA significantly attenuated CRC progression, evidenced by reduced colonic shortening and histopathological alterations compared to the CTL diet. Notably, the FAA enriched beneficial gut bacteria like Akkermansia and Bacteroides and reversed CRC-associated dysbiosis. Metabolomic analysis highlighted an increase in ornithine cycle metabolites and specific fatty acids, such as Docosapentaenoic acid (DPA), in FAA-fed mice. Transcriptomic analysis revealed that FAA up-regulated Egl-9 family hypoxia inducible factor 3 (Egln 3) and downregulated several cancer-associated pathways including Hippo, mTOR, and Wnt signaling. Additionally, DPA was found to significantly induce EGLN 3 expression in CRC cell lines. These results suggest that FAA modulate gut microbial composition, enhance protective metabolites, improve gut barrier functions, and inhibit carcinogenic pathways.
The invention relates to methods of providing a patient with aesthetic improvement procedures having two consultations. Aesthetic improvement information is obtained from the patient. Individual providers of aesthetic improvements are consulted a first time. A second consultation is conducted with multiple of the aesthetic improvement providers to provide an aesthetic improvement plan having recommendations that the are compatible with one another. The methods may also include adding the assessment and the results to a dynamic database. The methods may also include performing second diagnostic tests on the aesthetics of the patient after performing the aesthetic improvement procedure, performing a second consultation with the individual provider, the individual provider supplying an assessment of the results of the improvement procedure, and adding the assessment and the results to a dynamic database.
While experience with paliperidone overdose is limited, among the few cases of overdose reported in pre-marketing trials, the highest estimated ingestion of paliperidone was 405 mg. Observed signs and symptoms included extrapyramidal symptoms and gait unsteadiness. Other potential signs and symptoms include those resulting from an exaggeration of paliperidone’s known pharmacological effects, i.e., drowsiness and somnolence, tachycardia and hypotension, and QT prolongation. Torsade de pointes and ventricular fibrillation have been reported in a patient in the setting of overdose.

  


Paliperidone is the major active metabolite of risperidone. Overdose experience reported with risperidone can be found in the OVERDOSAGE section of the risperidone package insert.
The group Motivational Enhancement Tx/Cognitive Behavioral Tx (MET/CBT) treatment is a peer-focused, multi-component intervention involving 2 initial individual motivational sessions followed by 12 group sessions that includes a functional analysis of behavior to identify antecedents and consequences of drug use and skills training for coping with cravings, enhancing assertive communication, drug refusal, managing negative moods, problem-solving, decision-making, and relapse prevention. The additional inclusion of contingency management (CM) methods will provide immediate, tangible reinforcers as a consequence delivered contingently upon evidence of abstinence from substance use or other desirable behavior.
Splenic abscess is a life-threatening surgical emergency which requires early diagnosis and intervention to maximise patient outcomes. This can be achieved through accurate risk stratification in the emergency department (ED). Sarcopaenia refers to an age-related loss of skeletal muscle mass and strength with major physiologic and clinical ramifications. This study evaluates sarcopaenia as a radiological risk stratification tool to predict in-hospital mortality of splenic abscess patients.

99 adult patients at four training and research hospitals who had undergone abdominal contrast CT scans in the ED with the final diagnosis of splenic abscess from January 2005 to December 2015 were recruited. Evaluation for sarcopaenia was performed via calculating psoas cross-sectional area at level of L3 and normalising for height. Univariate analyses were used to evaluate the differences between survivors and non-survivors, with subsequent logistic regression analysis to assess odds ratio of sarcopaenia with respect to in-hospital mortality. A receiver operating characteristic (ROC) curve was plotted to determine predictability of sarcopaenia, with its corresponding sensitivity, specificity, and accuracy rate calculated.
COVID-19 disease progression can be accompanied by a "cytokine storm" that leads to secondary sequelae such as acute respiratory distress syndrome. Several inflammatory cytokines have been associated with COVID-19 disease progression, but have high daily intra-individual variability. In contrast, we have shown that the inflammatory biomarker γ' fibrinogen (GPF) has a 6-fold lower coefficient of variability compared to other inflammatory markers such as hs-CRP. The aims of the study were to measure GPF in serial blood samples from COVID-19 patients at a tertiary care medical center in order to investigate its association with clinical measures of disease progression. COVID-19 patients were retrospectively enrolled between 3/16/2020 and 8/1/2020. GPF was measured using a commercial ELISA. We found that COVID-19 patients can develop extraordinarily high levels of GPF. Our results showed that ten out of the eighteen patients with COVID-19 had the highest levels of GPF ever recorded. The previous highest GPF level of 80.3 mg/dL was found in a study of 10,601 participants in the ARIC study. GPF levels were significantly associated with the need for ECMO and mortality. These findings have potential implications regarding prophylactic anticoagulation of COVID-19 patients.
Patients with t(11;14) translocation will be enrolled in arm E1 and randomized to the venetoclax or the IPd control arm. Patients with relapsed Multiple Myeloma will receive Venetoclax, Ixazomib, Pomalidomide and Dexamethasone every cycle. Each cycle is 28 days long.
The aim of the present study was to determine the mediator role of psychological resilience in examining the effect of spiritual well-being on self-care agency in Chronic Obstructive Pulmonary Patients (COPD). The present cross-sectional and correlational study has a descriptive design, and it was conducted with 200 COPD patients admitted to the chest diseases outpatient clinic of a university hospital. "Spiritual Well-Being Scale (FACIT Sp-12)," "Brief Resilience Scale (BRS)" and "Self-Care Agency Scale (SCAS)" were used in the study for collecting the research data. STROBE recommendations were followed while reporting this study. FACIT Sp-12 total score average, the BRS total average score and the ASAS total average score of the patients were found to be 29.88 ± 1.44, 21.47 ± 66.31, and 84.81 ± 14.69, respectively. In addition, it was determined that both spiritual well-being (β = 0.170) and psychological resilience (β = 0.777) positively affected self-care agency. SCAS mediates the effect of FACIT-Sp-12 on self-care agency and strengthens the positive effect of FACIT-Sp-12 on self-care agency (β = 0.843). It was seen that the predictive effect of these two variables in explaining self-care power was 60%. Spiritual well-being and self-care agency of the COPD patients were found to be moderate, and the psychological resilience was found to be high. In addition, spiritual well-being was found to affect self-care agency directly and the mediating role of psychological resilience indirectly.
PROBLEM TO BE SOLVED: To make the component qualitatively uniform and hard to separate by a method wherein on a polymer chain which is properly charged, and can bond ions, a water soluble high molecular electrolytic substance having a fixed counter ion is selected and made a component. SOLUTION: A water soluble high molecular electrolytic substance which is selected in such a manner that a fixed ion of a polymer chain may bond an appropriate charged ion generated by an electrode during an ion osmotherapy is made a component for a hydrogel reservoir of a two compartment ion osmotherapy patch. For this high molecular electrolytic substance, one which can be blended with or dissolved with a polymer which constitutes a hydrogel phase of a matrix, and at the same time, medically allowable treatment is selected. Therefore, those which have Hg, Ag ions are not allowed. When this patch is housed in a lower reservoir 4 of a reservoir 1, and e.g. arranged on an excited pig skin or the like, the drug introduction is favorable.
TDCS is a noninvasive form of cortical stimulation that uses a battery-powered device. \[67\] Weak current (0.5-2 mA) will be delivered for up to 20 minutes through surface electrodes which will be positioned using the montage identified as the best in the individual stroke patient during our initial testing session during OT targeting the affected arm.
A dentifrice composition comprises a water-soluble inorganic or ionisable organic fluoride which may be present from 0.01 to 2% by weight of the composition, calculated as fluoride ions, and a polishing agent, which may be present from 20 to 99.5% by weight of the composition, which is a mixture of a water-insoluble polymetaphosphate and a calcium or magnesium carbonate or ortho-, pyro- or metaphosphate, the polymetaphosphate being present in an amount at least equal to that of the calcium or magnesium carbonate or phosphate.  Fluorides specified are stannous, sodium, potassium, ammonium, lithium, germanium and aluminium fluorides.  Suitable polymetaphosphates are sodium and potassium polymetaphosphates, Maddrell's and Kurrol's salts.  Other polishing agents which may be present are bentonite, kaolin, ground bone-meal, calcium sulphate, alumina gel, pumice, silica, whiting, tin oxide, hydrated magnesia, magnesia, magnesium trisilicate, and talc.  The composition which may take the form of a paste may have a pH between 5.7 and 7.5, or a powder, may contain surface-active agents, e.g. soap, sodium lauryl sulphate, p  oxygen yielding compounds, e.g. perborates, buffers, colouring, flavouring and sweetening agents, e.g. saccharin, and glycerol, sorbitol, gum tragacanth, sodium carboxymethyl cellulose, India moss, starch and colloidal clays.
Colorectal cancer (CRC) stands out as one of the most prevalent global cancers. The accurate localization of colorectal polyps in endoscopy images is pivotal for timely detection and removal, contributing significantly to CRC prevention. The manual analysis of images generated by gastrointestinal screening technologies poses a tedious task for doctors. Therefore, computer vision-assisted cancer detection could serve as an efficient tool for polyp segmentation. Numerous efforts have been dedicated to automating polyp localization, with the majority of studies relying on convolutional neural networks (CNNs) to learn features from polyp images. Despite their success in polyp segmentation tasks, CNNs exhibit significant limitations in precisely determining polyp location and shape due to their sole reliance on learning local features from images. While gastrointestinal images manifest significant variation in their features, encompassing both high- and low-level ones, a framework that combines the ability to learn both features of polyps is desired. This paper introduces UViT-Seg, a framework designed for polyp segmentation in gastrointestinal images. Operating on an encoder-decoder architecture, UViT-Seg employs two distinct feature extraction methods. A vision transformer in the encoder section captures long-range semantic information, while a CNN module, integrating squeeze-excitation and dual attention mechanisms, captures low-level features, focusing on critical image regions. Experimental evaluations conducted on five public datasets, including CVC clinic, ColonDB, Kvasir-SEG, ETIS LaribDB, and Kvasir Capsule-SEG, demonstrate UViT-Seg's effectiveness in polyp localization. To confirm its generalization performance, the model is tested on datasets not used in training. Benchmarking against common segmentation methods and state-of-the-art polyp segmentation approaches, the proposed model yields promising results. For instance, it achieves a mean Dice coefficient of 0.915 and a mean intersection over union of 0.902 on the CVC Colon dataset. Furthermore, UViT-Seg has the advantage of being efficient, requiring fewer computational resources for both training and testing. This feature positions it as an optimal choice for real-world deployment scenarios.
INTRODUCTION: Rheumatic heart disease with persistent atrial fibrillation (RHD-AF) is associated with increased morbidity. However, there is no standardized approach for the maintenance of sinus rhythm (SR) in them. We aimed to determine the utility of a stepwise approach to achieve SR in RHD-AF.
METHODS: Consecutive patients with RHD-AF from July 2021 to August 2023 formed the study cohort. The stepwise approach included pharmacological rhythm control and/or electrical cardioversion (Central illustration). In patients with recurrence, additional options included AF ablation or pace and ablate strategy with conduction system pacing or biventricular pacing. Clinical improvement, NT-proBNP, 6-Minute Walk Test (6MWT), heart failure (HF) hospitalizations, and thromboembolic complications were documented during follow-up.
RESULTS: Eighty-three patients with RHD-AF (mean age 56.13 ± 9.51 years, women 72.28%) were included. Utilizing this approach, 43 (51.81%) achieved and maintained SR during the study period of 11.04 ± 7.14 months. These patients had improved functional class, lower NT-proBNP, better distance covered for 6MWT, and reduced HF hospitalizations. The duration of AF was shorter in patients who achieved SR, compared to those who remained in AF (3.15 ± 1.29 vs 6.93 ± 5.23, p = 0.041). Thirty-five percent (29) maintained SR after a single cardioversion over the study period. Only one underwent AF ablation. Of the 24 who underwent pace and ablate strategy, atrial lead was implanted in 22 (hybrid approach), and 50% of these achieved and maintained SR. Among these 24, none had HF hospitalizations, but patients who maintained SR had further improvement in clinical and functional parameters.
CONCLUSIONS: RHD-AF patients who could achieve SR with a stepwise approach, had better clinical outcomes and lower HF hospitalizations.
Patients who fit the criteria of peers but refuse to be contacted by peer supporters will be signed as refused group. Half of the patients in this group will be randomized to receive a personalized feedback report displaying trends of metabolic control of A1c, BP, LDL-C, and body weight, with automated decision support based on their own attained values every 4 months through mails.
BACKGROUND: Increased 4-12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia. Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG). The aim of this study is to perform a systematic review on the use of coherence analysis for clinical assessment and treatment of dystonia.
METHODS: A systematic review was performed on a search in Embase and PubMed on June 28th, 2023. All studies incorporating coherence analysis and an adult dystonia cohort were included. Three authors evaluated the eligibility of the articles. Quality was assessed using the QUADAS-2 checklist.
RESULTS: A total of 41 articles were included, with data of 395 adult dystonia patients. In the selected records, six different types of coherence were investigated: corticocortical, corticopallidal, corticomuscular, pallidopallidal, pallidomuscular, and intermuscular coherence. Various types of 4-12 coherence were found to be increased in all dystonia subtypes.
CONCLUSION: There is increased 4-12 Hz coherence found between the cortex, basal ganglia, and affected muscles in all dystonia subtypes. However, the relationship between 4-12 Hz coherence and the dystonic clinical state has not been established. DBS treatment leads to a reduction of 4-12 Hz coherence. In combination with the results of this review, the 4-12 Hz frequency band can be used as a promising phenomenon for the development of a biomarker.