anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: Self-assessment of perceived communication difficulty has been used in clinical and research practices for decades. Such questionnaires routinely assess the perceived ability of an individual to understand speech, particularly in background noise. Despite the emphasis on perceived performance in noise, speech recognition in routine audiologic practice is measured by word recognition in quiet (WRQ). Moreover, surprisingly little data exist that compare speech understanding in noise (SIN) abilities to perceived communication difficulty. Here, we address these issues by examining audiometric thresholds, WRQ scores, QuickSIN signal to noise ratio (SNR) loss, and perceived auditory disability as measured by the five questions on the Speech Spatial Questionnaire-12 (SSQ12) devoted to speech understanding (SSQ12-Speech5).
DESIGN: We examined data from 1633 patients who underwent audiometric assessment at the Stanford Ear Institute. All individuals completed the SSQ12 questionnaire, pure-tone audiometry, and speech assessment consisting of ear-specific WRQ, and ear-specific QuickSIN. Only individuals with hearing threshold asymmetries ≤10 dB HL in their high-frequency pure-tone average (HFPTA) were included. Our primary objectives were to (1) examine the relationship between audiometric variables and the SSQ12-Speech5 scores, (2) determine the amount of variance in the SSQ12-Speech5 scores which could be predicted from audiometric variables, and (3) predict which patients were likely to report greater perceived auditory disability according to the SSQ12-Speech5.
RESULTS: Performance on the SSQ12-Speech5 indicated greater perceived auditory disability with more severe degrees of hearing loss and greater QuickSIN SNR loss. Degree of hearing loss and QuickSIN SNR loss were found to account for modest but significant variance in SSQ12-Speech5 scores after accounting for age. In contrast, WRQ scores did not significantly contribute to the predictive power of the model. Degree of hearing loss and QuickSIN SNR loss were also found to have moderate diagnostic accuracy for determining which patients were likely to report SSQ12-Speech5 scores indicating greater perceived auditory disability.
CONCLUSIONS: Taken together, these data indicate that audiometric factors including degree of hearing loss (i.e., HFPTA) and QuickSIN SNR loss are predictive of SSQ12-Speech5 scores, though notable variance remains unaccounted for after considering these factors. HFPTA and QuickSIN SNR loss-but not WRQ scores-accounted for a significant amount of variance in SSQ12-Speech5 scores and were largely effective at predicting which patients are likely to report greater perceived auditory disability on the SSQ12-Speech5. This provides further evidence for the notion that speech-in-noise measures have greater clinical utility than WRQ in most instances as they relate more closely to measures of perceived auditory disability.
Antibiotics are unavoidable to be prescribed to subjects due to different reasons, and they decrease the relative abundance of beneficial microbes. Inulin, a fructan type of polysaccharide carbohydrate, on the contrary, could promote the growth of beneficial microbes. In this study, we investigated the effect of inulin on antibiotic-induced intestinal microbiota dysbiosis and compared their overall impact at different supplementation stages, i.e., post-antibiotic, at the time of antibiotic administration or prior to antibiotic treatment, in the C57BL/6 mice model. Although supplementation of inulin after antibiotic treatment could aid in the reconstruction of the intestinal microbial community its overall impact was limited and no remarkable differences were identified as compared to the spontaneous restoration. On the contrary, the effect of simultaneous and pre-supplementation was more remarkable. Simultaneous inulin supplementation significantly mitigated the antibiotic-induced dysbiosis based on alterations as evaluated using weighted and unweighted UniFrac distance between baseline and after treatment. Moreover, comparing the effect of simultaneous supplementation, pre-supplemented inulin further mitigated the antibiotic-induced dysbiosis, especially on the relative abundance of dominant microbes. Collectively, the current study found that the use of inulin could alleviate antibiotic-induced microbiota dysbiosis, and the best supplementation stage (overall effect as evaluated by beta diversity distance changes) was before the antibiotic treatment, then simultaneous supplementation and supplementation after the antibiotic treatment.
In December 2019, a new coronavirus was identified in the Hubei province of central china and named SRAS-CoV-2. The spike protein (S) of SARS-CoV-2 contains two furin-like cleavage sites. The viral infection requires the priming or cleavage of the S protein and such processing seems essential for virus entry into the host cells. Furin is highly expressed in the lung tissue, suggesting the exploitation of this mechanism by the virus to mediate enhanced virulence. In the present invention, the inventors used structure-based virtual screening and a collection of about 8,000 unique approved and investigational drugs suitable for docking to search for molecules that could inhibits furin activity. Sulconazole, a broad-spectrum antifungal agent, was found to be of potential interest. Using Western blot analysis, Sulconazole was found to inhibit the cleavage of the cell surface furin substrate MT1-MMP that contains two furin cleavage sites similar to those of the SARS-CoV-2 spike protein. Sulconazole and analogs could be interesting for repurposing studies and to probe the yet not fully understood molecular mechanisms involved in cell entry.
Women randomised to the standard dietary care group will receive one dietary counselling consultation (60 min) according to the initial dietary counselling described without any follow-up consultations with a dietitian. Participants are encouraged to follow their dietary plan until delivery.
Provided is a technology which improves the adhesiveness between a biodegradable substrate film and a rubber-based pressure-sensitive adhesive layer. A pressure-sensitive adhesive tape is provided by a method comprising subjecting a surface of a biodegradable film (9) to a rubbing treatment by using a rubbing means (7) and then coating a liquid material for a pressure-sensitive adhesive layer to form a pressure- sensitive adhesive layer. The rubbing treatment results in the improvement of adhesiveness between the substrate film and the pressure- sensitive adhesive layer. When the liquid material for a pressure- sensitive adhesive layer is a rubber-based system, a primer having an organic compound as a solvent may be coated at first on a surface which has been subjected to a rubbing treatment to form a primer layer, followed by forming a pressure-sensitive adhesive layer. The pressure- sensitive adhesive layer may contain a filler, a colorant, an antioxidant and the like, as long as they do not adversely affect the biodegradability of the layer. It is desirable that a release film to be attached on the surface of the pressure-sensitive adhesive layer is also biodegradable.
Participants will complete computer-based response training tasks that will incorporate pictures of healthy food, unhealthy food, and glasses of water. As part of the computer-based training, participants will be instructed to respond or inhibit responses to certain of these stimuli in order to bring about a change in the participant response to certain stimuli. These tasks will be structured identically to those presented in the control condition, only the appearance and context of the stimuli will be different (i.e., food versus non-food items). The computer tasks described above comprise the Computer Based Response Training Weight Loss Intervention. To optimize the intervention, we narrowed the low-calorie food stimulus set to make a better distinction between high-calorie and low-calorie foods and we changed the filler images (water and furry mammals) in the go/no-go task from 100% "go" to 50% "go" and 50% "no-go" to measure learning of stimulus-specific respond associations.
BACKGROUND: Like the coronavirus disease 2019, the hepatitis B virus is also wreaking havoc worldwide, which has infected over 2 billion people globally. Using an experimental animal model, our previous research observed that the hepatitis B virus genes integrated into human spermatozoa can replicate and express after being transmitted to embryos. However, as of now, this phenomenon has not been confirmed in clinical data from patients.
OBJECTIVES: To explore the integration of the hepatitis B virus into patients' sperm genome and its potential clinical risks.
MATERIALS AND METHODS: Forty-eight patients with chronic hepatitis B virus infection were categorized into two groups: Test Group-1 comprised 23 patients without integration of hepatitis B virus DNA within the sperm genome. Test Group-2 comprised 25 patients with integration of hepatitis B virus DNA within the sperm genome. Forty-eight healthy male donors were included as control. The standard semen parameter analysis, real-time polymerase chain reaction, quantitative real-time polymerase chain reaction, sperm chromatin structure assay, fluorescence in situ hybridization, and immunofluorescence assays were utilized.
RESULTS: The difference in the median copy number of hepatitis B virus DNA per mL of sera between Test Group-1 and Group-2 was not statistically significant. In Test Group-2, the integration rate of hepatitis B virus DNA was 0.109%, which showed a significant correlation with the median copy number of hepatitis B virus DNA in motile spermatozoa (1.18 × 103/mL). Abnormal semen parameters were found in almost all these 25 patients. The integrated hepatitis B virus S, C, X, and P genes were detected to be introduced into sperm-derived embryos through fertilization and retained their function in replication, transcription, and translation.
CONCLUSION: Our findings suggest that hepatitis B virus infection can lead to sperm quality deterioration and reduced fertilization capacity. Furthermore, viral integration causes instability in the sperm genome, increasing the potential risk of termination, miscarriage, and stillbirth. This study identified an unconventional mode of hepatitis B virus transmission through genes rather than virions. The presence of viral sequences in the embryonic genome poses a risk of liver inflammation and cancer.
Subjects aged between, and including, 42 and 69 days at the time of first vaccination received 3 doses of Infanrix™ IPV and Hiberix™ co-administered at separate injection sites at 2, 4 and 6 months of age, 3 dose of Synflorix™ at 6 weeks, 3.5 and 5.5 months of age and 2 doses of Rotarix™ at 6 weeks and 3.5 months of age. The Infanrix™ IPV was administered intramuscularly in the right thigh, the Synflorix™ and Hiberix™ vaccines were administered intramuscularly in the left thigh and the Rotarix™ vaccine was administered orally.
A balance disorder rehabilitation robot based on virtual and real scene fusion has a follow-up supporting device, a weight loss protection device and a virtual projection device. The follow-up supporting device is arranged in the center position of a bottom surface of the weight loss protection device and is used to follow the balance training gait of a patient in real time. The weight loss protection device is used to follow the position of center of gravity of the patient in a process of balance rehabilitation training in real time. The virtual projection device is arranged in front of the follow-up supporting device to present a virtual scene. The postures and the positions of the follow-up platforms are controlled to realize the physical sense reproduction of multiple motion scenes. The physical scene is organically combined with the virtual scene to ensure a diverse balance rehabilitation training environment.
The invention relates to a time-space matching type hyperbranched polyether tissue engineering material and a preparation method thereof. The tissue engineering material is an amphiphilic hyperbranched polyether material containing a hydrophobic hyperbranched polyether (HP) part and a hydrophilic chain-terminated methoxy polyethylene glycol (mPEG) part. Chains contain biodegradable ester bond, ammonia ester bond, silicon ester bond, thioester bond and the like. The tissue engineering material can be prepared by an ammonia ester bond method or an ester bond method. Compared with the prior art, the time-space matching type hyperbranched polyether tissue engineering material provided by the invention is simple and feasible, and can realize industrial production. By adjusting the properties of each polymer constituent part, hyperbranched polyether materials with different degradation rates can be obtained. Also with good biocompatibility, the time-space matching type hyperbranched polyether tissue engineering material can achieve wide application when used for time-space matching type tissue engineering materials.
BACKGROUND: Subclinical seizures are common in hospitalized patients and require electroencephalography (EEG) for detection and intervention. At our institution, continuous EEG (cEEG) is not available, but intermittent EEGs are subject to constant live interpretation. As part of quality improvement (QI), we sought to estimate the residual missed seizure rate at a typical quaternary Canadian health care center without cEEG.
METHODS: We calculated residual risk percentages using the clinically validated 2HELPS2B score to risk-stratify EEGs before deriving a risk percentage using a MATLAB calculator which modeled the risk decay curve for each recording. We generated a range of estimated residual seizure rates depending on whether a pre-cEEG screening EEG was simulated, EEGs showing seizures were included, or repeat EEGs on the same patient were excluded.
RESULTS: Over a 4-month QI period, 499 inpatient EEGs were scored as low (n = 125), medium (n = 123), and high (n = 251) seizure risk according to 2HELPS2B criteria. Median recording duration was 1:00:06 (interquartile range, IQR 30:40-2:21:10). The model with highest residual seizure rate included recordings with confirmed electrographic seizures (median 20.83%, IQR 20.6-26.6%), while the model with lowest residual seizure rate was in seizure-free recordings (median 10.59%, IQR 4%-20.6%). These rates were significantly higher than the benchmark 5% miss-rate threshold set by 2HELPS2B (p<0.0001).
CONCLUSIONS: We estimate that intermittent inpatient EEG misses 2-4 times more subclinical seizures than the 2HELPS2B-determined acceptable 5% seizure miss-rate threshold for cEEG. Future research is needed to determine the impact of potentially missed seizures on clinical care.
The purpose of this study was to evaluate the treatment outcomes of patients with pachychoroid neovasculopathy (PNV) who received photodynamic therapy (PDT) combined with intravitreal anti-vascular endothelial growth factor (VEGF) agents, with a particular focus on the fluorescein angiography (FA) findings. We retrospectively studied 33 eyes of 32 consecutive treatment-naïve patients with PNV who were scheduled for PDT combined with anti-VEGF agents between November 2017 and May 2022, with a follow-up period of 1 year or longer. We classified patients into two groups: central serous chorioretinopathy (CSC)-dominant type and macular neovascularization (MNV)-dominant type based on the baseline FA findings. The best-corrected visual acuity (BCVA) was compared before treatment and at 3, 6, and 12 months after the initial treatment. Additionally, recurrence rate, and number of additional injections during the maintenance phase were assessed. We classified 19 eyes with the CSC-dominant type, and 14 eyes with the MNV-dominant type. The BCVA improved significantly 1 year after the initial treatment only in the CSC-dominant type (P = 0.001). The recurrence rate in the maintenance phase was lower in the CSC-dominant type (15.8%) compared to the MNV-dominant type (57.1%), a difference that reached significance (P = 0.024).This study highlights the distinct treatment outcomes between the CSC-dominant and MNV-dominant types; specifically, CSC-dominant type had better visual improvement and a lower recurrence rate than the MNV-dominant type. These differences underscore the potential of FA as a useful biomarker to predict visual outcomes and recurrence in the maintenance phase in patients with PNV.
Acne vulgaris (AV) is the eighth most prevalent disease worldwide. Acne is a self-limiting condition, it may cause significant psychological and social problems, depression, disfigurement, and scarring that can persist for a lifetime. Multiple factors contribute to acne pathogenesis including increased sebum production, aberrant keratinization of the pilosebaceous duct, bacteria such as Propionibacterium acnes, hormonal influences, the skin microbiome, and chronic inflammation. Relapse rates in patients with acne after treatment with standard of care vary between 10% and 60%. Recent trials attempted to assess the effect of zinc in reducing the severity of symptoms of acne vulgaris patients. This study evaluates whether there is any role of zinc in reducing acne symptoms between those who did and did not receive zinc in an 8 weeks period. This includes 122 acne vulgaris patients who were recruited from Dermatology and Venereology OPD of BSMMU. Participants took either 20 mg elemental zinc daily in the form of zinc sulphate tablet or 20 mg placebo tablet daily for 8 weeks. Initially, baseline serum zinc level was measured and repeated again after 8 weeks of intervention. A baseline acne symptoms survey was done by GAGS score and also repeated at 8 weeks.
The patient should be warned to report immediately the appearance of sore throat, fever, chills or sore mouth. Advice should be given to avoid constipation, and the patient should be made aware that alopecia may occur and that jaw pain and pain in the organs containing tumor tissue may occur. The latter is thought possibly to result from swelling of tumor tissue during its response to treatment. Scalp hair will regrow to its pretreatment extent even with continued treatment with vinblastine sulfate. Nausea and vomiting, although not common, may occur. Any other serious medical event should be reported to the physician.
In one embodiment of the invention, a method is disclosed to locate a robotic instrument in the field of view of a camera. The method includes capturing sequential images in a field of view of a camera. The sequential images are correlated between successive views. The method further includes receiving a kinematic datum to provide an approximate location of the robotic instrument and then analyzing the sequential images in response to the approximate location of the robotic instrument. An additional method for robotic systems is disclosed. Further disclosed is a method for indicating tool entrance into the field of view of a camera.
The invention relates to innovative cancer resistance and tumor removal medicine formed by repeated scientific experiments of natural rare traditional Chinese medicine in the Qinba mountainous area. Eight types of traditional Chinese medicine including typhonium giganteum, roxburgh anoectochilus terminal buds, radix clematidis, honeysuckles, adder tongue herb, Qixing sword, galium aparine and patrinia scaniosaefolia are aired or dried after impurities and dust are removed, smashed 1-3 times according to ratios, and subpackaged into 150-180 g with one bag of 200 g so as to be taken orally. The medicine is quite good in effect for patients suffering from breast cancer, cervical cancer, malignant mole, esophagus cancer, stomach cancer and rectal cancer. By orally taking the innovative cancer resistance and tumor removal medicine for breast cancer, cervical cancer and esophagus cancer and externally-bonded medicine for external application, through the cooperation of diet therapy regimen with an additional formula given as a present, cancer cells are promoted to lose growth hotbeds, and cancer cells gradually wither and die. The aims of existing with tumor, coexisting peacefully, achieving diet therapy regimen and making tumor withered are achieved. The aims of self-rescue, survival, health and long life of patients are achieved.
Four (4) subjects will receive one (1) treatment, six (6) months after the previous treatment with the eZ App 8 large applicator to the abdomen. This is the same applicator that is being evaluated in this study. These subjects have been treated on-site at the Laser \& Skin Surgery Center of New York by the study doctor.
A composition for promoting hair growth, which contains a mixture of kappa tripeptide, salicylic acid, tocopheryl acetate and nicotinic acid amide is provided to promote the hair growth by providing the nutrition and maintain the hair growth phase. A composition for promoting hair growth comprises a mixture of kappa tripeptide, salicylic acid, tocophrol acetate, nitotinic acid amide in a weight ratio of 0.5-10: 1-15: 10-30: 1-10 as an active ingredient. The kappa tripeptide is obtained by reacting a glycine, histidine, and lysine and reacting tripeptide(Gly-His-Lys) with copper chloride. The salicylic acid is included in o-oxybenzoic acid and denoted by the chemical formula C7H6O3. The tocopheryl acetate is denoted by the chemical formula C31H52O3. The nicotinamide is one of the vitamin B complex included in a pyridine-3-carboxyamide and denoted by the chemical formula C6H6N2O. The composition is used in an external skin preparation, cosmetic product or cleansing agent. The external skin preparation is used in a form of powder, gel, ointment, cream, liquid, or aerosol. The cosmetic product is used in a form of nutrition cream, astringent, skin softener, lotion, essence, nutrition gel, massage cream or powder formulation. The cleansing agent is used in a form of soap, shampoo, or rinse.
Postoperative delirium is characterized by widespread brain involvement and its incidence is between 6% and 30%. It appears twice as often after cardiac and vascular surgery than other types of surgery. The correlation between optic nerve sheath diameter (ONSD) and invasive intracranial pressure measurement is excellent. ONSD reduction has the potential to indicate intracranial hypoperfusion causing delirium. In this observational study, patients aged 18 years and over who will undergo open heart surgery will be examined. ONSD will be measured using ultrasound five times in the perioperative period (t0: pre-induction, t1: post-induction, t2: onset of cardiopulmonary bypass (CPB), t3: post-CPB, and t4: post-ICU admission). The Confusion Assessment Method for the ICU (CAM-ICU) test will be used to examine delirium in the ICU. Whether the change in ONSD is an independent risk factor for delirium will be evaluated.
Affiliated athletes are frequently subject to higher levels of anxiety due to the intensity of training, competition and many other factors. This anxiety can cause alterations in their health, both physically and mentally, such as menstrual irregularities, eating disorders, etc. In this work we have analysed the anxiety levels of a population of female affiliated paddlers and the possible consequences for their health. The results showed that a third of the female paddlers analysed have a moderate/high risk of suffering from anxiety; and within this group, the less sporting experience the athlete has, the greater the probability is of suffering from anxiety. Moreover, almost half the total of the female paddlers suffers from menstrual dysfunction before an important competition, with this number rising among high performance athletes, even though three out of every four adjust their training schedule to their menstrual cycle. Less-experienced female athletes, who show higher anxiety levels, also present a greater risk of suffering from eating disorders.