anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Metastasis to the lungs is a leading cause of death for patients with breast cancer. Therefore, effective therapies are urgently needed to prevent and treat lung metastasis. In this study, we uncovered a mechanism by which NAD(P)H:quinone oxidoreductase 1 (NQO1) orchestrates lung metastasis. NQO1 stabilized and upregulated peptidyl-prolyl cis-trans isomerase A (PPIA), a chaperone that regulates protein conformation and activity, by preventing its oxidation at a critical cysteine residue C161. PPIA subsequently activated CD147, a membrane protein that facilitates cell invasion. Moreover, NQO1-induced secretion of PPIA modulated the immune landscape of both primary and lung metastatic sites. Secreted PPIA engaged CD147 on neutrophils and triggered the release of neutrophil extracellular traps (NET) and neutrophil elastase, which enhanced tumor progression, invasiveness, and lung colonization. Pharmacological targeting of PPIA effectively inhibited NQO1-mediated breast cancer lung metastasis. These findings reveal a previously unrecognized NQO1-PPIA-CD147-NET axis that drives breast cancer lung metastasis. Inhibiting this axis is a potential therapeutic strategy to limit lung metastasis in patients with breast cancer.  Significance: NQO1 stabilizes and promotes the secretion of PPIA to activate CD147 in neutrophils and stimulate NET formation, promoting breast cancer lung metastasis and providing therapeutic targets for this fatal condition.
Local reactions consisting of pain, urticaria or ulceration may occur at the site of injection. A permanent discoloration may remain along the path of the sclerosed vein segment. Sloughing and necrosis of

tissue may occur following extravasation of the drug. (See WARNINGS section.) 

Allergic reactions such as hives, asthma, hay fever and anaphylactic shock have been reported. Mild systemic reactions that have been reported include headache, nausea and vomiting. (See WARNINGS section.) 

At least six deaths have been reported with the use of sodium tetradecyl sulfate injection. Four cases of anaphylactic shock leading to death have been reported in patients who received sodium tetradecyl sulfate injection. One of these four patients reported a history of asthma, a contraindication to the administration of sodium tetradecyl sulfate injection. (See WARNINGS section.) 

One death has been reported in a patient who received sodium tetradecyl sulfate injection and who had been receiving an antiovulatory agent. Another death (fatal pulmonary embolism) has been reported in a 36-year-old female treated with sodium tetradecyl acetate and who was not taking oral contraceptives. 

Cerebrovascular accident, myocardial infarction

To report SUSPECTED ADVERSE REACTIONS, contact Hikma Pharmaceuticals USA Inc. at 1-877-845-0689 or FDA at 1-800 FDA-1088 or www.fda.gov/medwatch.
The invention relates to preparation of a bismuth-containing compound, in particular to bismuth alginate and a preparation method and application thereof. The structure of the bismuth alginate is shown as Formula 1, wherein n is equal to 200-250. The bismuth alginate is prepared via reaction of algin and bismuth salt or bismuth alkali in alkaline aqueous solution, and the alginic acid is prepared via ethanol precipitation and separation, dehydration, drying and grinding. The bismuth alginate is synthesized with alginic acid as a bismuth carrier, the bismuth content of the bismuth-containing compound is lower than the bismuth content of bismuth preparations universally applied in clinics at present, and the potential toxicity of long-term administration of the bismuth can be reduced. Moreover, the bismuth-containing compound has the biological activity of both bismuth preparations and alginic acid and has multi-functions of protecting the gastric mucosa, neutralizing the gastric acid, reducing the activity of pepsin, killing Hp, and promoting healing of peptic ulcer wounds. Therefore, the bismuth-containing compound has good values in new drug development. Formula I is shown in the description.
Fibromyalgia (FM) is a chronic non-degenerative disease of unknown etiology without effective medical treatment that mostly affects women. At present, the diagnostic and classification criteria are still under debate. As a result, the treatments for FM are also under investigation. No single treatment has achieved a reduction in the symptoms. Its occurrence increases with age. Exercise is one of the treatment approaches where effectiveness in the management of FM is supported by stronger evidence. Besides, recent reviews found that exercise has a positive effect on pain, physical function and health-related quality of life .with no associated adverse effects. Among the different exercise modalities available, core stability training has shown its effectiveness by improving static and dynamic balance, functionality and risk of falls, pain and quality of life. so This study will be conducted to investigate the effect of core exercises on health status, pain, pressure pain thresholds and functional capacity in patients with FM
A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt. % per hour from the second to the twentieth hour after introduction to a use environment and less than about 25 wt.% for the first two hours and at least 70 wt.% by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet. In another embodiment, the dosage form releases less than about 25 wt.% of sertraline to the use environment by the second hour after introduction of the dosage form to the use environment, and delivers at least 25 wt.% from the eighth to the twenty-fourth hour. <IMG>
Participants will first be randomly assigned to a parent-mediated social communication intervention. At month 3 participants' social communication will be evaluated. Participants who present with delayed social communication skills will be randomly assigned to 2 additional treatment options: continue, or add video feedback. Participants who do not present with social communication delays will reduce intervention to a weekly phone call.
The invention discloses a method, a system and a device for assisting a user in positioning a cell position of a medical image, and belongs to the field of image processing. In the cell position marking process, a user can obtain the complete three-dimensional shape positioning of the current cell by clicking any position of a certain cell on any two-dimensional plane. The spatial position occupied by the cell will be identified in the two-dimensional image sequence as a series of red open circles of varying radius. The user does not need to repeatedly browse the two-dimensional image sequence to search the mark at the position with the largest radius of the current cell. The cell locations of all user markers will be identified in the two-dimensional image sequence by red open circles of varying series radii. Unlabeled cells are not identified. This operation can prevent the user from repeatedly labeling the same cell in the sequence image, and will effectively improve the efficiency of cell labeling. The method helps the user to check the cell marking results in different dimensions, and improves the accuracy and efficiency of marking the cells by simultaneously displaying the two-dimensional and three-dimensional visual interfaces.
This invention provides compositions and methods for producing a medical device such as a stent or a synthetic graft, coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes which range from about C60 to about C100.  The antibodies promote adherence of endothedial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies.
Systems, methods, and apparatus for automatically pre-constructing a clinician consultation note during a patient intake or admission process are disclosed herein. The example systems, methods, and apparatus are configured to automatically populate a clinical consultation note by extracting relevant medical information from unstructured past medical documentation in addition to incorporating patient data from an active sheet comprising a medical questionnaire form. The active sheet is configured to acquire structured patient data from a patient through the use of defined data entry fields. The active sheet is programmed with logic such that selection of some data entry fields will cause the inclusion of additional data entry fields. The logic is defined to replicate a physician's own medical training to prompt patients for more detailed patient data regarding a specific medical condition in an automated manner. Such a configuration is more efficient and ensures that key medical questions are not overlooked.
Apatinib(YN968D1) ,850mg,p.o.,qd,continuous. plus autologous cytokine-induced killer cells 3 cycles,every 1 year,continuous.
1. Technical Result Increase in medicinal means stability.          2. Essence A pharmaceutical composition comprises a core in the form of a tablet with a medicament, which is sensitive to a low pH environment of less than 3, such as dd1, and a soluble enteric coating formed of methacrylic acid copolymer and a plasticizer. The tablets may be of varying sized and may be orally ingested individually or a plurality of tablets sufficient to attain a desired dosage may be encapsulated in a dissolvable capsule. The tablets have excellent resistance to disintegration at pH less than 3, but have excellent drug release properties at pH greater than 4.5.          3. Field of Application Medicine.
Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system (CNS) that is characterized by inflammation, demyelination, and neurodegeneration. It remains the most common non-traumatic cause of neurologic disability in young adults and presents in most patients as relapsing-remitting disease. Relapses, caused by inflammatory demyelination, can result in a significant amount of neurological disability and reduced health-related quality of life, and having frequent early relapses is associated with increased risk of longer-term disability. Clinical recovery from early relapses is incomplete in approximately half of patients with MS. The mechanisms underlying relapse recovery are not completely understood.

Remyelination of acutely denuded axons is one mechanism by which relapse recovery may occur. Remyelination is suspected to occur via newly differentiated oligodendrocytes, which are derived from oligodendrocyte precursor cells (OPCs) in the CNS. However, despite the presence of this innate repair mechanism, many patients go on to develop progressive functional disability. This may be due to a failure of remyelination or because of progressive axonal injury. Chronic demyelinating lesions are surrounded by OPCs and premyelinating oligodendrocytes, which suggest that failed remyelination does occur and could be partially due to incomplete oligodendrocyte differentiation. Additionally, recent studies have highlighted the importance of mitochondrial dysfunction, perhaps related to oxidative stress or increased energy demands, in mediating MS disease progression. Mitochondrial dysfunction may drive axonal degeneration with resultant neurodegeneration and progressive neurological decline (progressive MS). While numerous immune modulating therapies exist, currently, there is an urgent need for novel therapies that have neuroreparative and neuroprotective properties.

Thyroid hormones may play a direct role in remyelination and repair in the adult CNS by promoting maturation of oligodendrocytes. Further, thyroid hormones have been shown to reduce oxidative stress and thus may have the capacity to prevent mitochondrial dysfunction as well. Since tri-iodothyronine (T3) is believed to mediate the most important thyroid hormone actions, liothyronine (synthetic form of T3) has the potential to induce reparative mechanisms and limit secondary neurodegeneration in MS. In mice, T3 administration has shown to help facilitate recovery from cuprizone-induced demyelination. In this study, the investigators propose to perform a phase 1 study in patients with MS to establish a tolerable dose of liothyronine, evaluate the safety of this medication, determine whether it impacts function, and evaluate if it is associated with changes in neurotrophic and/or inflammatory biomarkers in the cerebrospinal fluid (CSF).
Caregivers watch introduction video on a DVD over 10 minutes at baseline. Caregivers receive Prepare to Care kit including 8 workbook modules and complete at least 1 module over 30-45 minutes each week. Caregivers also attend interventionist session over 10-30 minutes weekly.
The intervention proposal will be developed in a module with 10 elderly people, all of them men, with moderate dependence and older, with an average age of 84 years. All of them have multiple medical pathologies with the need for continuous nursing care.
One or more hair care products and/or techniques for creating such hair care products are provided. For example, a hair care product comprises one or more carriers, such as a coconut oil, an evening primrose, and/or a hemp oil. The hair care product comprises one or more oils, such as a lavender oil, a tee tree oil, a nettle leaf oil, a horsetail extract, a clary sage oil, a rosemary oil, a basil oil, a lemongrass oil, a cypress oil, a cinnamon leaf oil, and/or a roman chamomile. The hair care product may be used for restructuring (e.g., relaxing) a natural growth pattern of hair. The hair care product may stimulate hair follicles so that protein and/or moisturizing portions of the hair care product may seep into the scalp for growing and sustaining healthy hair. The hair care product may treat or mitigate eczema, dryness, breakage, sores, and/or fungal bacteria.
Sham cerebellar tDCS plus SFA for 15 sessions (25-minutes per each 60-minute treatment session) over the course of 3-5 weeks. Current will be administered in a ramp-like fashion, but after the ramping, the intensity will drop to 0 mA. SFA will be delivered by a Speech and Language Pathologist to improve naming.
The invention relates to a perfume composition which, at the same time, has a tanning effect or both a sun-block and tanning effect. According to the invention, the perfume composition having a tanning effect or both a sun-block and tanning effect is comprised of a clear hydroalcoholic solution. Said solution contains an alcohol-soluble, organic sunscreen filter in a proportion of 0.05 to 12 wt. %; dihydroxyacetone in a proportion of 0.5 to 10 wt. %; one or more monovalent alcohols with 3 to 5 carbon atoms in a proportion of 30 to 85 wt. %; one or more polyvalent alcohols with 3 to 5 carbon atoms in a proportion of 0.5 to 15 wt. %; perfume oil in a proportion of 1 to 20 wt. %; and water in a proportion of 3 to 67.95 wt. %, hereby the proportions refer each time to the total composition.
Burning mouth syndrome (BMS) patients in Caffeine group were provided with BMS disease explanation and psychological counseling. Then they were told to drink instant coffee containing 120-150 mg of the active ingredient caffeine (2 bags of Nescafe Black Coffee, 1.8g each) at a certain point in time from 8:00 to 12:00 every day, for 2 consecutive weeks.
PURPOSE: To obtain a multifunctional substance showing excellent inhibitory action on melanism by using dried rhizome of Acorus gramineus and leaves of Eribotrya japonica widely useful as crude medicines from ancient times, having highly evaluated safety, adding an alcohol to an extract of them with hot water and separating precipitate. CONSTITUTION: Dried rhizome of Acorus gramineus and leaves Eribotrya japonica are used as raw materials, preferably de-fatted and exacted with hot water at 90-100 deg.C. After extraction with hot water, the extracted solution is cooled to a room temperature or below it and mixed with an alcohol such as methanol or ethanol. Then the mixture is subjected to solid-liquid separation treatment such as centrifuging, filtration and decantation, separated into sediment (precipitate) and supernatant liquid (filtrate) to collect a multifunctional polysaccharide fraction and a multifunctional low-molecular fraction, respectively. The multifunctional polysaccharide fraction has inhibiting action on melanism, antiinflammatory action, antioxidizing action, moisture absorbing action or moisture retaining action.  The supernatant liquid is further treated and is used as its concentrated substance, pasty substance, diluted substance or dried substance. These substances are useful in the field of skin science.
Preterm birth is a major public health concern, requiring a deeper understanding of its underlying inflammatory mechanisms and to develop effective therapeutic strategies. This review explores the complex interaction between inflammation and preterm labor, highlighting the pivotal role of the dysregulation of inflammation in triggering premature delivery. The immunological environment of pregnancy, characterized by a fragile balance of immune tolerance and resistance, is disrupted in preterm labor, leading to a pathological inflammatory response. Feto-maternal infections, among other pro-inflammatory stimuli, trigger the activation of toll-like receptors and the production of pro-inflammatory mediators, promoting uterine contractility and cervical ripening. Emerging anti-inflammatory therapeutics offer promising approaches for the prevention of preterm birth by targeting key inflammatory pathways. From TLR-4 antagonists to chemokine and interleukin receptor antagonists, these interventions aim to modulate the inflammatory environment and prevent adverse pregnancy outcomes. In conclusion, a comprehensive understanding of the inflammatory mechanisms leading to preterm labor is crucial for the development of targeted interventions in hope of reducing the incidence of preterm birth and improving neonatal health outcomes.
The clinical data of coronary heart disease(CHD) patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2023 were retrospectively collected. This study involved the descriptive analysis of demographic characteristics, clinical symptoms, and tongue and pulse features. The χ~2 test was conducted to analyze the distribution of syndrome elements and their combinations at diffe-rent stages of CHD, so as to reveal the clinical characteristics and syndrome patterns at various pathological stages of CHD. This study extracted 28 symptom entries, 10 tongue manifestation entries, and 7 pulse manifestation entries, summarized the 5 main disease locations of the heart, lung, liver, spleen, and kidney, and the 8 main disease natures of blood stasis, phlegm turbidity, Qi stagnation, heat(fire), fluid retention, Qi deficiency, Yin deficiency, and Yang deficiency and 8 combinations of disease natures. The χ~2 test showed significant differences in the distribution of syndrome elements including the lung, liver, spleen, kidney, blood stasis, heat(fire), Qi stagnation, heat syndrome, water retention, Qi deficiency, Yin deficiency, and Yang deficiency between different disease stages. Specifically, the liver, blood stasis, heat(fire), and Qi stagnation accounted for the highest proportion during unstable stage, and the lung, spleen, kidney, water retention, Qi deficiency, Yin deficiency, and Yang deficiency accounted for the highest proportion at the end stage. The distribution of Qi deficiency varied in the different time periods after percutaneous coronary intervention(PCI). As shown by the χ~2 test of the syndrome elements combination, the distribution of single disease location, multiple disease locations, single disease nature, double disease natures, multiple natures, excess syndrome, and mixture of deficiency and excess varied significantly at different stages of CHD. Specifically, single disease location, single disease nature, and excess syndrome accounted for the highest proportion during the stable stage, and double disease natures accounted for the highest proportion during the unstable stage. Multiple disease locations, multiple disease natures, and mixture of deficiency and excess accounted for the highest proportion during the end stage. In conclusion, phlegm turbidity and blood stasis were equally serious during the stable stage, and a pathological mechanism caused by blood stasis and toxin existed during the unstable stage. The overall Qi deficiency worsened after PCI, and the end stage was accompanied by the Yin and Yang damage and the aggravation of water retention. There were significant differences in the distribution of clinical characteristics and syndrome elements at different stages of CHD. The pathological process of CHD witnessed the growth and decline of deficiency and excess and the combination of phlegm turbidity and blood stasis, which constituted the basic pathogenesis.
The analysis of alterations in the expression and functionality of brain-derived exosomal miRNAs within ischemic stroke lesions provides significant insights into the mechanisms that contribute to disease recovery. We assessed spontaneous motor function in a rat model of permanent middle cerebral artery occlusion (pMCAO) using motor function scores and magnetic resonance imaging (MRI). Brain-derived exosomes from the infarcted brain tissue of the animal model were extracted and high-throughput sequencing of them was performed followed by bioinformatics analysis for differentially expressed miRNAs target genes. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to measure expression levels of differentially expressed miRNAs at various time points. The oxygen-glucose deprivation (OGD) model was established to investigate gene function through the assessment of cell proliferation and apoptosis using EdU proliferation and JC-1 apoptosis assay. The rat model demonstrated a spontaneous recovery of motor function and a reduction in cerebral infarction area from day 1 to day 14 post-operation. Over the course of the recovery period, miR-24-3p, miR-129-1-3p, and miR-212-5p maintained consistent expression levels, reaching their peak on the initial day following surgery. In the cell model, EdU detection indicated that miR-129-1-3p promoted cellular proliferation, while JC-1 detection revealed its suppressive impact on cellular apoptosis. The current research findings indicated the presence of spontaneous motor function restoration in a rat model of ischemic stroke. MiR-24-3p, miR-129-1-3p, and miR-212-5p were identified as pivotal genes in this recovery process, with miR-129-1-3p potentially influencing the restoration of spontaneous motor function in ischemic stroke through the regulation of neuronal proliferation and apoptosis.