anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
During accelerated dose titration in Group 1, participant will receive duvortuxizumab starting at 0.5 nanogram per kilogram (ng/kg) for biweekly dosing. Dose will be increased by half logarithmic steps in subsequent Dose Level (DL). After safety stopping criteria are met, Dose Escalation (DE) in Group 1 will transition to 3+3 design, and will continue until the Maximum tolerated Dose (MTD) is defined. DE in Groups 2 and 3 will follow 3+3 design, begin after initial dose level in Group 1 is deemed safe and recommended phase 2 doses (RP2D) for Part 1 of study can be decided. Duvortuxizumab at a starting dose of 50 ng/kg weekly will also be investigated in Group 1 and will follow 3+3 study design continue until the MTD or Maximum administered dose (MAD) is reached. Disease-specific dose escalation in Group 2 and 3 will not be initiated until dose in Group 1 is determined safe.
From 2018-2020, 19 states enacted Medicaid work requirements as a strategy for reducing program enrollment and overall cost. While these requirements were later rescinded, strategies to reduce Medicaid costs are likely to reemerge as states attempt to recover economically from the COVID-19 pandemic. Here, we evaluated the impact of Medicaid work requirements on adults aged > 50, a group that likely faces significant age-related chronic disease burden. Using 2016 Health and Retirement Study data, we evaluated the chronic disease burden of adult Medicaid beneficiaries aged 51-64 years (n = 1460) who would be at risk of losing their Medicaid coverage due to work requirements. We compared Medicaid beneficiaries working <20 hours per week (i.e. those at risk of coverage loss) to those working at least 20 hours per week on eight chronic health conditions, adjusting for demographic characteristics. Among those with chronic health conditions, we also evaluated differences in disease severity based on hours worked per week. Among those working fewer than 20 hours per week, odds of disease were greater for seven of eight chronic conditions, including history of stroke (OR: 5.66; 95% CI: 2.22-14.43) and lung disease (OR: 3.79; 95% CI: 2.10-6.85). Further, those with greater disease severity were likely to work fewer hours. Thus, the introduction of Medicaid work requirements would likely result in coverage loss and lower access to care among older Medicaid beneficiaries with multiple chronic health conditions.
A topical composition comprising silver sulfadiazine, preferably 0.5wt% to 1.5wt%; an acrylates/beheneth-n methacrylate copolymer wherein n is an integer between 20 and 30, preferably 0.03wt% to 2.0wt%; a surfactant mixture which comprises a sorbitan ester and a sorbital ester (sorbityl ester), wherein the mean number of carbon atoms of the hydrophobe of the sorbitan ester is greater than that of the sorbitol ester, preferably 0.5wt% to 8wt%; and an acceptable diluent or carrier, is provided. Preferably the sorbitan ester is selected from the group including sorbitan cocoate, sorbitan caprate, sorbitan laurate, sorbitan myristate, sorbitan palmitate and sorbitan stearate, in particular sorbitan stearate. Preferably the sorbitol ester is selected from the group including sorbitol cocoate, sorbitol caproate, sorbitol laurate, sorbitol myristate, sorbitol palmitate and sorbitol stearatem in particular sorbitol laurate. The acrylates/beheneth-n methacrylate copolymer is preferably an acrylates/beheneth-25 methacrylate copolymer. Preferably the topical composition is an oil-in-water emulsion wherein the diluent or carrier preferably comprises both an aqueous diluent/carrier and a hydrophobic diluent/carrier. A method of preparing the silver sulfadiazine composition is also provided. The topical silver sulfadiazine composition is preferably a sprayable composition for the prophylaxis, inhibition and/or treatment of infection in wounds, such as severe burn wounds.
An ocular biometer utilizing a light emitting source and corresponding optics to illuminate areas of the eye in order to analyze the wavefront of the reflected light. Aperture sharing elements, such as "hot mirrors" are used to allow the eyes to view the world, was the ocular biometer measures various characteristics of the eye such as the refractive (i.e., accommodative) state, the gaze angle and the pupil diameter at any instant of time and continuously. Optical wavefront conditioning and wavefront sensing techniques are used to determine the refractive power of the eye and the instantaneous accommodative state. Reflected light is projected through a reticle or plurality of reticles. Spatial characteristics of the resulting shadow pattern uniquely determine the characteristics of the eye. These shadow patterns can be measured directly or by causing a modulation of the lines with a second identical reticle placed appropriately between the first and the imaging plane. The bright pupil and a Purkinje image may be used to compute the gaze angle (or, line-of-sight).
The present invention provides a heteroaromatic ring compound serving as a CDK7 kinase inhibitor, preparation thereof, and a use thereof. The heteroaromatic ring compound is a compound having the structure of formula (I) or a pharmaceutically acceptable salt, ester, stereoisomer, solvent compound or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound having the structure of formula (I) or the pharmaceutically acceptable salt, ester, stereoisomer, solvent compound or prodrug thereof. The present invention further provides a use of the compound having the structure of formula (I) or the pharmaceutical composition in the preparation of a CDK7 kinase inhibitor and in the preparation of a drug for treating and/or inhibiting CDK-related diseases. The CDK7 kinase inhibitor compound of the present invention has an enzyme and cell level biological activity superior to that of disclosed similar target compounds and lower cardiotoxicity. The compound of the present invention provides more options for novel antitumor drugs, and has good prospects of application in drugs.
A hair shaping process for producing permanent waves uses, as hitherto, the treatment of the hair with an alkaline liquid containing a reducing agent, and uses a so-called fixing step in which the hair is oxidised with an acidic liquid. The novelty consists in that the oxidation step with acidic treatment liquid is carried out in two stages, and in that the first stage takes place before, and the second stage takes place after, the reducing step with alkaline liquid. Alkaline conditions above a pH of about 7.5 or even 8 are avoided with the new process. The double sulphur bridges in the hair are no longer destroyed. Excessive crinkling of sensitive hair is no longer possible. The treatment is milder and the appearance of the permanent wave is more natural.
Hepatocellular carcinoma (HCC) is associated with a poor prognosis, and its incidence has increased dramatically in many countries. Hepatectomy is a radical therapy for early-stage HCC. However, even after radical resection, the prognosis for HCC patients remains discouraging because of the high recurrence rate and frequent incidence of intrahepatic metastasis. Therefore, preventing HCC recurrence is very important.

Hepatitis B virus (HBV) infection is the major risk factor for HCC development in China. Some retrospective studies have shown that tenofovir or entecavir treatment for HBV-related HCC patients can effectively reduce the HCC recurrence rate and increase the survival rate after hepatectomy. However, which drug has more efficacy has not been addressed.
BACKGROUND: Accumulating evidence indicates that neutrophil activation (NA) contributes to microvascular thromboinflammation in acute ischemic stroke (AIS) due to a large vessel occlusion. Preclinical data have suggested that intravenous thrombolysis (IVT) before endovascular therapy (EVT) could dampen microvascular thromboinflammation. In this study we investigated the association between NA dynamics and stroke outcome, and the impact of IVT on NA in patients with AIS treated with EVT.
METHODS: A single-center prospective study was carried out, including patients treated with EVT for whom three blood samples (before, within 1 hour, 24 hours post-EVT) were drawn to measure plasma myeloperoxidase (MPO) concentration as a marker of NA. Unfavorable outcome was defined as a modified Rankin score of 3-6 at 3 months.
RESULTS: Between 2016 and 2020, 179 patients were included. The plasma MPO concentration peaked significantly 1 hour post-EVT (median increase 21.0 ng/mL (IQR -2.1-150)) and returned to pre-EVT baseline values 24 hours after EVT (median change from baseline -0.8 ng/mL (IQR -7.6-6.7)). This peak was strongly associated with unfavorable outcomes at 3 months (aOR 0.53 (95% CI 0.34 to 0.84), P=0.007). IVT before EVT abolished this 1 hour post-EVT MPO peak. Changes in plasma MPO concentration (baseline to 1 hour post-EVT) were associated with unfavorable outcomes only in patients not treated with IVT before EVT (aOR 0.54 (95% CI 0.33 to 0.88, P=0.013). However, we found no significant heterogeneity in the associations between changes in plasma MPO concentration and outcomes.
CONCLUSIONS: A peak in plasma MPO concentration occurs early after EVT and is associated with unfavorable outcomes. IVT abolished the post-EVT MPO peak and may modulate the association between NA and outcomes.
Previous research on providing incentives for healthy behaviors has shown that financial incentives can increase treatment participation and boost outcomes when they are tied to participation in evidence based treatments. However, most of this research has been done in laboratory settings and in relatively small clinical trials. This study is designed to test the hypotheses that incentives can increase both participation in smoking cessation treatment and resulting cessation rates, when they are offered to Wisconsin BadgerCare Plus (Medicaid) smokers as part of their health care. If successful, this treatment approach could be used more broadly to reduce the considerable financial and personal costs associated with smoking-related disease.

In this study, Medicaid-eligible smokers were recruited from primary care clinics and from callers to the Wisconsin Tobacco Quit Line (WTQL) with randomization a Control condition and an Incentive condition. All participants were offered five cessation calls from the WTQL and participants were encouraged by WTQL coaches to obtain cessation medication from their primary care providers. All participants received payment for completing a baseline assessment ($40) and a 6-month smoking test ($40). Only Incentive condition participants received additional compensation for taking counseling calls ($30 per completed call) and for biochemically-verified abstinence at the 6-month visit ($40).
Background and Objectives: The aim of this study was to compare the effectiveness of pericapsular nerve group (PENG) and lumbar erector spinae plane (L-ESP) blocks, both administered with a high volume (40 mL) of local anesthetic (LA), for multimodal postoperative analgesia in patients undergoing hip surgery. Materials and Methods: This was a prospective, double-blind, randomized study that included 75 adult patients who were divided into three equal groups: control, PENG, and L-ESP. The study compared pain intensity, morphine consumption, time to first morphine request, and postoperative satisfaction between the control group, which received standard multimodal analgesia, and the block groups, which received PENG or L-ESP block in addition to multimodal analgesia. The numerical rating scale (NRS) was used to measure pain intensity. Results: The results showed that the block groups had lower pain intensity scores and morphine consumption, a longer time to the first morphine request, and higher postoperative satisfaction compared to the control group. The median maximum NRS score during the first 12 h was four in the control group, two in the PENG group, and three in the L-ESP group. The control group (21.52 ± 9.63 mg) consumed more morphine than the two block groups (PENG, 11.20 ± 7.55 mg; L-ESP, 12.88 ± 8.87 mg) and requested morphine 6.8 h earlier and 5 h earlier than the PENG and L-ESP groups, respectively. The control group (median 3) had the lowest Likert satisfaction scores, while the PENG group (median 4) had the lowest NRS scores (L-ESP, median 4). Conclusions: The application of PENG or L-ESP blocks with high-volume LA in patients undergoing hip surgery reduces the need for postoperative analgesia and improves the quality of multimodal analgesia.
There is wide variation in the time from the onset to secondary progressive multiple sclerosis (MS) and some controversy regarding the clinical characteristics of the courses (phenotypes) of MS. The present study aimed to characterize demographic and clinical factors that potentially influence long-term disability progression in the cohort of Latvian MS patients. A descriptive longitudinal incidence study was conducted using a cohort of 288 MS patients beginning in 2011 (disease duration from 1 to 51 years). Socio-demographic and clinical information from the first visit to 15/20 years was analysed in groups stratified by gender and visits at five-time points (the first visit; after a year or 2; after 5 ± 1 year; after 10 ± 2 years; after 15-20 years). Our study was dominated by patients from urban areas and non-smokers. The female/male ratio was 2.4:1; the distribution of clinical courses at the first visit was consistent with most European studies. The most common symptom at presentation in our study was optic manifestations, followed by sensory disturbances and motor deficits. In the Latvian study, gender was not a significant influencing factor on the rate of disease progression; however, patient age was statistically significantly associated with EDSS (Expanded Disability Status Scale) value at the first visit. Early clinical features of MS are important in predicting the disability accumulation of patients. Despite the small differences regarding the first MS symptoms, the disability outcomes in the cohort of Latvian patients are similar to other regions of the world.
An artificial intelligence triage disposition process is described. A system trains a machine-learning model to determine triage disposition levels for archived clinical data for triage system users. The trained machine-learning model derives data combinations from clinical data from a triage system user, and generates probabilities, based on the derived data combinations, for triage disposition levels. If any probability satisfies any triage disposition level’s threshold, the system identifies the highest triage disposition level associated with any probability which satisfies any triage disposition level’s threshold. If the highest level is not the highest possible triage disposition level, the system prods the user with a question, which elicits data for a higher triage disposition level. The system determines the highest triage disposition level’s threshold satisfied by a probability based on the derived data combinations and the user reply to the question. The system outputs the highest triage dispositions level to the user.
Hyponatremia, has become increasingly recognized as a cause of morbidity and mortality in hospitalized children. The main etiology of hyponatremia in these children has been attributed to the use of hypotonic maintenance IV fluids. The practice of providing IV solutions containing 20-30 mmol/L of Na is based on "physiological needs" proposed by Holliday and Segarin 1957, derived from studies of 61 adults and children. The presence of non-physiologic ADH secretion in the great majority of hospitalized children due to nausea, stress, pain, and surgical interventions, has confirmed that Holliday and Segar's recommendations are frequently inappropriately applied. To avoid the development of hyponatremia, it has been suggested that isotonic 0.9% NaCl/dextrose 5% should be the standard maintenance IV solution.

The routine use of an isotonic maintenance fluid solution has not yet been studied, and concerns exist regarding the potential for hypernatremia and salt and water overload. If isotonic solutions are to be recommended routinely, their overall safety, and specifically the occurrence of dysnatremias and volume overload, should be evaluated in a controlled prospective trial.
This study was conducted to investigate the effectiveness of Mulligan concept cervical sustained natural apophysial glides (SNAGs) mobilization method in addition to the conventional treatment program in patients with nonspecific neck pain. The study included 40 patients (18-50 years of age) with non-specific neck pain, radicular compression and loss of strength for at least 3 months, diagnosed by a specialist physician; patients with central nervous system disease, distal-peripheral nerve injuries Patients with inflammatory joint disease, cervical spine fracture or surgery, patients with upper extremity surgery, cervical spine tumor and infection, cervical spine congenital anomaly and diabetes were not included in the study. 15 sessions were applied for 3 weeks, 5 days a week for 10 weeks, 10 minutes ultrasound, 20 minutes transcutaneous electrical nerve stimulation (TENS) and hotpack application and Mulligan mobilization in addition to physiotherapy programs. The patient was rested for 5 seconds between sets. The physiotherapy program was applied to the control group and the application session was completed. Normal range of motion exercises were performed in both groups and given as home exercise.
PURPOSE:To obtain a reagent for a clotting reaction between a reverse passive antibody and a red blood cell having high specificity to the ovary cancer and blasenmole by sensitizing the specific antihuman BMAP antibody obtd. by immunizing the refined basement membrane protein (abbreviated as BMAP) obtd. from the human placenta to an animal with the red blood cell of another animal. CONSTITUTION:The BMAP which is recovered from the human placenta and has about 10,000mol.wt., 3.5pH at the isoelectric point, and the easy mobility by electrophoresis in the beta- globulin region and contains 10% hexose is immunized to a horse, by which the antihuman BMAP antibody is obtd. Such anitbody which is sensitized with the red blood cell of a sheep is freeze-dried and is suspended in a phosphoric acid buffer soln., to which sodium azide is added and the reagent that can be preserved is obtd. A kit is constituted of such reagent, a standard human plasma positive control, a standard human plasma negative control and a buffer soln. for measurement. A specified amt. of the reagent is added to the double-double diluted system of a liquid to be examined and the resulted precipitate is compared with the clotting of the positive control and the settling image (small and distinct) of the negative control and the max. dilution time at which the positive clotting is admitted is determined as the quantity of the human BMAP. The quick and exact diagnosis of the ovary cancer and blasenmole is thus made possible.
PURPOSE:To enable the preventing of pains of patients and damage to a mucosa during the insertion into a human body by applying a resin cover containing hydrophilic polymer bondable to a film base material by a covalent bond to one surface of the film base material while the other surface thereof has an adhesive layer to allow the removal and reformation of a lubricating resin film in terms of the use of medical apparatuses. CONSTITUTION:One surface of a film base material 3 has a resin cover 2 while the other surface thereof has an adhesive layer 4. A hydrophilic polymer composing the resin cover 2 is dissolved well in water and when the solution exists between certain materials, friction resistance between both the materials is lowered remarkably, which allows the use of the polymer as lubricant. When these materials are bonded to a reactive functional group which exists in or is introduced into the base material of the film base material 3 or on or into the surface thereof by a covalent bond, a lubricant layer carried on the base material is obtained. This provides a lubricating surface which lasts long not dissolved in water. It is suffice to apply a tape 1 at a necessary part of a medical device. This helps reduce a friction resistance at a part with the tape inserted in vivo to relieve a patient or the like of burden. The tape is replaced in every use.
It is usually reported that there is a parallelism between changes in the bone structure and function and the muscle structure and function. Sarcopenia is frequently observed in osteoporotic patients. Bone formation increases or bone resorption decreases with exercise.

One of the most important functions of bone bear mechanical loads include body weight. Bone must be strong enough to resist the mechanical loading. Mechanisms need to protect bone when bone is subject to excessive mechanical loading. These mechanisms may mainly focus on strengthening the bone and/or changing vectorial properties of mechanical loading applied bone.

The vectorial properties of mechanical loading applied bone may be controlled by muscle contractions. Bone contains wide mechanoreceptor net constructed by osteocytes. So,distribution of the mechanical loading on bone cross-sectional area is possible to perceive. It may be also possible that inappropriate distribution of mechanical loading on bone crosssectional area is optimized by muscle contractions. To get this regulation, there should be a mechanism that muscle activity is controlled by central nervous system based on mechanical loading distribution on bone cross-sectional area. The investigators previously showed that bone can regulate muscle activity, based on its bone mineral density. According to this study result, it can be suggested there may exist a mechanism that bone sensing mechanical stimuli can send the signals to central nervous system and neuronally regulate muscle activity (bone myo-regulation reflex). (It is also well known that load-induced adaptive bone formation is neuronally regulated. Taken together, a general mechanism, bone reflex, may be defined that bone subjected to loading can neuronally regulate bone formation and muscle activity) Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. It has been showed that bone has an effect on the increase in muscle EMG activity caused by vibration in healthy young adults in a study. In this study, it was reported that vibrations-induced increases in muscle electrical activity of flexor carpi radialis (FCR) was related to ultradistal radius bone mineral content (BMC) and the FCR H-reflex was suppressed or depressed during vibration. This findings were reported to support the assumption that the bone exposed to cyclic mechanical loading may neuronally regulate muscle activity.

The aim of this study is to investigate effects of femur exposed to vibration on the rest muscle electrical activity of hip adductors in cases with postmenopausal osteoporosis.