anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Psychological dependence, physical dependence and tolerance are known to occur with hydromorphone. Therefore, hydromorphone should be prescribed and administered with caution.

The severity of the abstinence syndrome is related to the degree of dependence, the abruptness of withdrawal and the drug used. If the abstinence syndrome is precipitated by administration of a narcotic antagonist, symptoms appear within a few minutes and are maximal within thirty minutes. Administration of a narcotic antagonist as a means of detecting dependence is not usually recommended. Withdrawal symptoms in patients dependent on hydromorphone include yawning; sweating; lacrimation; rhinorrhea; a restless, tossing sleep; dilated pupils; goose flesh; irritability; tremor; nausea; vomiting and diarrhea. Treatment of the abstinence syndrome is primarily symptomatic and supportive, including maintenance of proper fluid and electrolyte balance.

Tolerance, in which increasingly large doses are required in order to produce the same degree of analgesia, is manifested initially by a shortened duration of analgesic effect and subsequently by decreases in the intensity of analgesia. The rate of development of tolerance varies among patients.
Valproate can cause decreased IQ scores following in utero exposure. Published epidemiological studies have indicated that children exposed to valproate in utero have lower cognitive test scores than children exposed in utero to either another antiepileptic drug or to no antiepileptic drugs. The largest of these studies 1 is a prospective cohort study conducted in the United States and United Kingdom that found that children with prenatal exposure to valproate (n=62) had lower IQ scores at age 6 (97 [95% C.I. 94 to 101]) than children with prenatal exposure to the other antiepileptic drug monotherapy treatments evaluated: lamotrigine (108 [95% C.I. 105 to 110]), carbamazepine (105 [95% C.I. 102 to 108]), and phenytoin (108 [95% C.I. 104 to 112]). It is not known when during pregnancy cognitive effects in valproate-exposed children occur. Because the women in this study were exposed to antiepileptic drugs throughout pregnancy, whether the risk for decreased IQ was related to a particular time period during pregnancy could not be assessed. 

Although all of the available studies have methodological limitations, the weight of the evidence supports the conclusion that valproate exposure in utero can cause decreased IQ in children. 

In animal studies, offspring with prenatal exposure to valproate had malformations similar to those seen in humans and demonstrated neurobehavioral deficits [see Use in Specific Populations (8.1)].
The invention relates to an invisible protective agent. The invisible protective agent is composed of the components of, by weight: 10-13 parts of edible casein, 30-38 parts of dehydrated ethanol, 4-7 parts of a plasticizing agent, 9-12 parts of propylene glycol, 32-40 parts of purified water, 1-1.5 parts of anhydrous sodium carbonate, 0.5-0.6 parts of vitamins, and 0.03-0.06 parts of an essence. All the components of the nontoxic invisible protective agent provided by the invention can be purchased from the market, and are nontoxic materials. The components are safe and nontoxic. The invisible protective agent can directly form a protective film on skins. The invisible protective agent can also be used on various articles, and can form protective films on the articles, such that anti-fouling and anti-oil functions can be provided. The plasticity and adhesion of the invisible protective agent are high. A preparation method of the protective agent is advantaged in simple operation. The protective agent is advantaged in convenient application. The protective agent can be used in large-batch production and marketing, and can be produced and applied in independent small dosages. The production is convenient and fast.
PURPOSE:To produce a large amount of a physiologically active substance having anti-tumor activity, by transplanting carcinoma cells to a normal mammalian animal, administering an immuno-activating substance to the cancerous animal, administering a component originated from a specific bacterial cell, etc. to the animal, and separating the objective substance from the animal. CONSTITUTION:Carcinoma cells (e.g. RL-male 1) are transplanted in the skin of a normal mammalian animal (e.g. BALB/C more). An immino-activating substance (e.g. killed cell of Corynebacterium parvum, living cell of B.C.G, etc.) is administered to the animal e.g. by intravenous injection to effect the primary stimulation of the animal, and then the animal is administered with a component originated from bacterial cell represented by the bacterial LPS, or a synthetic polysaccharide or a synthetic lipopolysaccharide as a secondary stimulant e.g. by intravenous injection. The body fluid or blood collected from the animal is purified by the combination of the basic anion exchange chromatography, gel filtration, etc. to obtain the substance having a TNF-like activity in a state having high activity.
OBJECTIVES: The causal relationship between intrinsic capacity and frailty in older adults, as well as the underlying temporal mechanisms, remained poorly understood. The study aimed to investigate the causal association between intrinsic capacity and frailty while exploring the potential mediating role of self-perception of aging.
MEASUREMENTS: A survey was conducted with a sample of 429 participants who completed measures of intrinsic capacity, self-perception of aging, and frailty at baseline and were followed for one year. The relationships between these variables were assessed using an autoregressive cross-lagged model.
RESULTS: The study found reciprocal associations between intrinsic capacity and frailty (p < 0.01). Furthermore, the results indicated that self-perception of aging partially mediated the effect of frailty at baseline (T1) on intrinsic capacity at one-year follow-up (T2) (β = -0.02, confidence interval: [-0.055, -0.004]). However, the reverse causation was not observed.
CONCLUSIONS AND IMPLICATIONS: This study demonstrates a bidirectional causal relationship between intrinsic capacity and frailty in older adults. Self-perception of aging plays a significant mediating role in this relationship. Older adults with a worse level of frailty should be made aware of the potentially vicious cycle related to self-perception of aging, which can negatively affect their intrinsic capacity. Maintaining a positive self-perception of aging may help preserve physical and psychological reserves, maintain intrinsic capacity, and slow the decline of frailty.
A method for diagnosis or aiding in the diagnosis of Sjogren's Syndrome (SS). The diagnosis method requires testing a sample obtained or derived from a subject for an amount of Taxilin alpha, wherein determining an amount of Taxilin alpha that is more than a reference comprises a diagnosis or aids in a diagnosis that the individual has SS, and wherein determining an amount of Taxilin alpha that is the same as or less than a reference indicates the individual does not have SS. A mAb or Taxilin alpha-binding fragment thereof ("Taxilin alpha") having an antibody heavy chain; an antibody light chain, an antibody comprising a heavy chain and/or an antibody. A kit of the same monoclonal antibody or Taxilin alpha-binding fragment thereof. A method of making the Taxilin alpha. The making method requires separating the Taxilin alpha from a cell culture that expresses the Taxilin alpha.
INTRODUCTION: Detailed postoperative rehabilitation protocols after hip arthroscopy for femoroacetabular impingement syndrome (FAIS) are still a matter of debate. Adjunctive hip bracing represents a promising tool to improve early patients' mobilization. To present, the effect of hip brace therapy on postoperative functional outcomes and specific patient individual psychologic factors remains controversially discussed. Consequently, we aimed to report postoperative outcomes focusing on hip function, pain and kinesiophobia between braced and unbraced patients.
MATERIALS AND METHODS: A prospective, randomized-controlled trial was conducted, including patients undergoing hip arthroscopy for FAIS. After exclusion, a final study cohort of 36 patients in the intervention group (postoperative hip brace) and 36 patients in the control group (no hip brace) were compared for kinesiophobia (Tampa Scale of Kinesiophobia), pain (Visual analog scale) and joint function (International Hip Outcome Tool-12) within the first six postoperative months.
RESULTS: Hip arthroscopy significantly improved all patient-reported outcomes in both groups. Intergroup analysis revealed significantly lower levels of kinesiophobia in braced patients at 6-months follow up (30.7 vs. 34.1, p = 0.04) while not negatively affecting pain and joint function. No intra- and postoperative complications occurred within both groups.
CONCLUSIONS: This study could demonstrate that bracing after hip arthroscopy can positively influence kinesiophobia, while the brace did not negatively impact postoperative pain and quality of life. Thus, hip bracing could be a viable assistive therapy in the postoperative rehabilitation phase after hip arthroscopy.
The progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive species with lipid peroxidation is ferroptosis, which shows hallmarks of both programmed and necrotic death in vitro. While evidence of ferroptosis in neurodegenerative disease is indicated by iron accumulation and involvement of lipids, a stable marker for ferroptosis has not been identified. Its prevalence is thus undetermined in human pathophysiology, impeding recognition of disease areas and clinical investigations with candidate drugs. Here, we identified ferroptosis marker antigens by analyzing surface protein dynamics and discovered a single protein, Fatty Acid-Binding Protein 5 (FABP5), which was stabilized at the cell surface and specifically elevated in ferroptotic cell death. Ectopic expression and lipidomics assays demonstrated that FABP5 drives redistribution of redox-sensitive lipids and ferroptosis sensitivity in a positive-feedback loop, indicating a role as a functional biomarker. Notably, immunodetection of FABP5 in mouse stroke penumbra and in hypoxic postmortem patients was distinctly associated with hypoxically damaged neurons. Retrospective cell death characterized here by the novel ferroptosis biomarker FABP5 thus provides first evidence for a long-hypothesized intrinsic ferroptosis in hypoxia and inaugurates a means for pathological detection of ferroptosis in tissue.
The application provides a health management method, a related device and a communication system. The method is built based on a data bank. The processing of user data in a data bank may include the collection, processing, opening, and presentation of value of user data. In the method, the electronic device can provide a triage number reservation scheme and post-treatment medication reminding, diet suggestion, exercise suggestion, shopping suggestion and other health management suggestions for the user by using the user data. The electronic device may also recommend the health management advice to an electronic device in the same family group as the electronic device. The electronic device can also receive the diagnosis result of the family member of the user and provide a scheme for monitoring the health condition of the family member. In addition, the electronic equipment can also provide the use suggestion of the electronic equipment for the user according to the physical condition of the user. The method can help the user to manage the physical health of the user and the family.
BACKGROUND: Catastrophic loss of the penis following post-circumcision necrosis is a rare and devastating complication. Treatment options are limited, and the process is highly challenging. This study aims to report the successful application of our combined treatment approach for a 6-year-old patient who experienced total penile loss due to progressive necrosis 1 year after circumcision.
METHODS & RESULTS: Following penile degloving, proximal penile mobilisation and separation and reshaping of the corpora were performed. The penile shaft was covered with a tunnelled composite anterior-lateral inguinal skin flap. Glanuloplasty was performed using a left buccal mucosal graft, followed by 10 sessions of hyperbaric oxygen therapy. At 1.5 months postoperatively, urethral dilation was performed once because of minor voiding difficulties. At 10 months postoperatively, the patient had excellent voiding function and no additional complaints. The patient expressed high satisfaction with the outcome and is still under close follow up.
CONCLUSIONS: A standard treatment for serious complications such as necrosis and total penile loss has not been established yet. Although scrotal skin flap is a straightforward technique, it was not preferred in our case because of fibrosis following scrotal necrosis and potential risk of hair growth. The developed approach could be an effective alternative to other techniques.
Physical activity levels of patients with chronic obstructive pulmonary disease (COPD) are low due to the symptoms of COPD. The patients diagnosed with COPD are headed for complementary and alternative treatments to reduce the COPD symptoms, facilitate the treatment, and increase their physical activity. One of these treatments is QiGong, which is not yet common in our country. QiGong is a type of exercise based on ancient Chinese medicine, and mainly consists of active and passive exercises. These exercises open energy channels in the body, and thus prevent and/or heal diseases by establishing energy balance in the body through meditation, breath control, and bodily exercises. According to a literature review abroad, there are a small number of scientific studies related the therapeutic effect of QiGong exercises on symptom control, anxiety, reduction of stress and depression, increase in physical activity and quality of life, and the development of lung function of patients with COPD. By considering the educative role of nurses, it is important that the nurse has adequate knowledge of the treatment and care of patients with COPD. Therefore, this review is compiled to be informative about the effects of QiGong in the treatment of COPD, and assistance to subsequent studies.
Participants will continue to receive their usual standard care related to CF (i.e., accessing services through their local health authority and CF clinic). Following the proposed maximum program completion time-frame (i.e., 6 weeks) and follow-up time period (i.e., 3 months), those in the standard care groups will be provided access to iCF-PWR.
In the experimental group, the laser pen was turned on, and the acupoint stimulation was performed for about 3-5 minutes. Each acupoint was performed once a day. The patient wore goggles and observed the patient's vital signs (blood pressure, heartbeat, and blood pressure) with a physiological monitor. Oxygen), if the patient has any discomfort, the procedure will be stopped, and the patient's defecation status will be recorded/evaluated every day for up to 10 days (including Saturdays and Sundays). The post-test questionnaire will be conducted on the day of discharge, and the phone will be followed within one month after discharge. Inquire about the follow-up situation.
Disclosed are a glycosaminoglycan lyase having difficulty degrading CS-E and an encoding gene and the use thereof. The amino acid sequence of the glycosaminoglycan lyase is as shown in SEQ ID NO. 2, and the nucleotide sequence of the encoding gene of the glycosaminoglycan lyase is as shown in SEQ ID NO. 1. The specific activities of the glycosaminoglycan lyase on HA and CS-A, CS-C, CS-D and CS-E are 13.8, 7.2, 6.7, 5.9 and 5.3 U/mg, respectively, and lowly sulphated CS-E polysaccharides are used as substrates to prepare highly sulphated oligosaccharides with different degrees of polymerisation, and the prepared highly sulphated oligosaccharides can be used for combating tumour metastasis. The enzyme can also be applied to fields such as medicine and cosmetics and has broad application prospects.
Endoscopic submucosal dissection (ESD) is an endoscopic technique that involves the use of an endoscopic knife to gently peel off a superficial neoplasia of any size in an en-bloc fashion. It meets the principles of onco-surgery and is associated with excellent outcomes. A difficulty however with the technique is control of bleeding during the procedure. The GI mucosa is a vascular territory and the current method of managing intraprocedural bleeding is electrocautery using either the endoscopic knife itself or the coag grasper. This introduces a thermal injury to the bowel wall and carries the risk of causing a perforation or causing pain. Furthermore, it requires precise targeting of the bleeding vessel. Practically this can be challenging, particularly if the coag grasper is needed which is a bulky device and can be difficult to apply precisely in some locations.

PuraStat® (3-D Matrix Ltd, Tokyo) is a liquid which is applied to a bleeding area which acts rapidly to form a gel coat which induces haemostasis. This transparent adherent barrier permits further endoscopic therapy to be performed. It can be applied in the general area of bleeding and does not require precise application to the exact point of bleeding. It is applied through a small catheter placed through the biopsy channel of the endoscope which can be used in very small spaces.

PuraStat® is licensed as a CE marked device for use in exudative haemorrhage from vessels in solid organs and within the GI tract. Given this indication, the role of PuraStat in ESD needs to be explored as it could reduce the need for thermal haemostasis. This would be of significant clinical benefit during ESD.
Obesity is a chronic and complex disease affecting millions of people worldwide. Currently, there is no standard definition of success for the management of obesity. We set out to complete a synthesis of clinical practice guidelines for obesity management for adult populations, aiming to provide both a quantitative descriptive and qualitative analysis of definitions of success in clinical practice guidelines. An electronic search retrieved 4477 references. Sixteen clinical practice guidelines were included after screening and full-text review. We coded definitions of success 147 times across the included guidelines. No standard or explicit definition of success was identified in the guidelines but rather success was implicitly defined. We developed three themes describing how success was defined in the clinical practice guidelines: Knowledge-based decision making; management of expectations; and the perception of control. The review reinforced that success is an inherently subjective and complex concept. Defining success is limited by existing studies that focus on weight loss and would benefit from additional research on different outcomes. Equally, the relationship between people living with obesity and their clinicians should be further explored to understand how defining success is controlled, discussed and framed in a clinical setting.
The SYNERGY Registry is an international prospective, observational cohort study of eligible adult and pediatric pts with advanced solid and hematological malignancies, for whom the decision to consider CTE has already been made by their primary providers (PP). Using a proprietary application programming interface (API) linked to existing electronic health records (EHR) platforms, individual clinical data is extracted, analyzed and matched to a parametric database of existing institutional and non-institutional CT. Machine learning algorithms allow for dynamic matching based on CT allocation and availability for optimized matching. Patients voluntarily enroll into the registry, which is non-interventional with no protocol-mandated tests/procedures - all treatment decisions are made at the discretion of PP in consultation with their pts, based on the AI CT matching report, and VTB support. CTE will be assessed on variables including biomarkers, barriers to enrollment. Study duration anticipated as \~36 mo (\~24-mo enrollment followed by 12 mo of data collection, to occur every 3 mo). The primary analysis will be performed 12 mo after last pt enrolled. The impact time to initiation of CTE on PFS and OS will be estimated by Kaplan-Meier and Cox multivariable survival analysis. Enrollment is ongoing, with a target of ≥50,000 patients.
The investigators will focus on mGluR5 PET binding as a surrogate measure for level of activity of the mTOR kinase pathway. This study is being conducted by the New York State Psychiatric Institute (NYPSI) and the Research Foundation for Mental Hygiene Inc (RFMH) and will take place at Columbia University Medcial Center (CUMC) in New York City and at a research office in Strasburg, PA. Subjects (n=20) with the CNTNAP2 mutation with schizophrenia or a related condition will be recruited from the Amish and Mennonite communities and brought to CUMC for detailed investigation. Affected individuals will be compared to Old-Order Amish control patients drawn from the same families but not harboring CNTNAP2 mutations (n=20). The primary measure will consist of mGluR5 PET binding in DLPFC. In addition, secondary analyses will assess binding in other brain regions such as hippocampus and visual cortex. Exploratory measures, as well as relationships between PET mGluR5 binding and clinical symptomatology,will be assessed.
PROBLEM TO BE SOLVED: To obtain a hair tonic, having excellent effects on prevention of alopecia and promotion of hair restoration, growth, etc., by using a specific hydrolyzate prepared from a xyloglucan. SOLUTION: This hair tonic is obtained by using a xyloglucan hydrolyzate, prepared by partially hydrolyzing xyloglucan and having <=50cP viscosity of its 3% aqueous solution measured by a Brookfield type viscometer as an active ingredient. The amount of the xyloglucan hydrolyzate used is preferably 0.005-10wt.%, especially preferably 0.05-5wt.%. A xyloglucan, derived from a readily available tamarind seed and having a high content of xyloglucan is preferred as a raw material for the xyloglucan hydrolyzate. Since the xyloglucan hydrolyzate is readily dissolved in a hydrous ethanol, it can be used as a hair tonic and a hair restorer. The hair tonic is capable of assuming a preparation form, e.g. a tonic, a hair cream or a shampoo.
In sequence 1, period 1, participants will be dosed with a single administration of oral contraceptive (OC). Participants will continue directly into period 2 where they will receive PF-06700841 PO for 13 days with a single dose of OC administered on the morning of day 10.
An in vivo screening method reliably predicts calcification of implantable prosthetic material by implanting the prosthetic material intramuscularly in an animal. Calcification of the material is much more rapid when implanted in the muscle, as opposed to subcutaneous implantation, because of the greater calcium flux within muscle tissue, so that after a specified implant duration, the implanted material has relatively high calcification. The higher calcification provides greater resolution in the results. For example, calcification of intramuscularly implanted material may be on the order of 200 ν µg Ca/mg of dry tissue after 90 days when implanted in a rabbit, as opposed to less than 10 ν µg Ca/mg of dry tissue when implanted subcutaneously in a rat. Prosthetic material such as bovine pericardium tissue is implanted in the paravertebral muscle of a small animal such as a rabbit. Incisions are made through the skin of the animal, and a pocket is then formed in the muscle through each incision. The prosthetic material under test is then positioned within the pockets, and the incisions are closed. After the specified implant duration, the material is explanted and analyzed.