anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subjects will receive 20 mg Suvorexant beginning the first in-hospital night ("day 0") and continuing for their hospital stay. If the dose is not well tolerated (e.g., daytime sleepiness), then the dose may be decreased to 10 mg of Suvorexant. For blinding purposes, each arm will receive two tablets (two 10 mg tablets or one 10 mg tablet and a placebo). Suvorexant will be administered beginning on the night after surgery and through the hospitalization period (it is estimated that stays will be 1-3 days; subjects will be followed for a maximum of 5 days).
PCT No. PCT/US92/11333 Sec. 371 Date Nov. 7, 1994 Sec. 102(e) Date Nov. 7, 1994 PCT Filed Dec. 31, 1992 PCT Pub. No. WO94/15633 PCT Pub. Date Jul. 21, 1994This invention relates to a method of combatting cancer which cancer releases chorionic gonadotropin or a subunit thereof present in a mammal which method comprises administering to said animal an anti-cancer effective amount of a birth-control vaccine or an antibody to said chorionic gonadotropin or subunit thereof. Birth-control vaccines which are polyvalent vaccines and birth-control vaccines which employ recombinant organisms incorporating sequences coding for reproductive hormones are of particular interest as well as polyclonal and monoclonal antibodies to the chorionic gonadotropin.
After anesthesia induction, patients who were randomized to the Placebo group received a bolus and infusion of 0.9% normal saline at the same rate as the Dexmedetomidine group until the end of surgery. In the case of intraoperative increment of the blood pressure and/or heart rate more than 25% from its baseline, fentanyl 1ug/kg was administered.
Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease with high morbidity and mortality. Periodontitis exacerbates COPD progression; however, the immune mechanisms by which periodontitis affects COPD remain unclear. Here, by constructing periodontitis and COPD mouse models, we demonstrated that periodontitis and COPD could mutually aggravate disease progression. For the first time, we found that the progression was associated with the activation of γδ T cells and M2 macrophages, and M2 polarization of macrophages was affected by γδ T cells activation. In the lung tissues of COPD with periodontitis, the activation of γδ T cells finally led to the increase of IL 17 and IFN γ expression and M2 macrophage polarization. Furthermore, we found that the periodontitis-associated bacteria Porphyromonas gingivalis (P. gingivalis) promoted the activation of γδ T cells and M2 macrophages ex vivo. The data from clinical bronchoalveolar lavage fluid (BALF) samples were consistent with the in vivo and ex vivo experiments. For the first time, our results identified the crucial role of γδ T-M2 immune mechanism in mediating periodontitis-promoted COPD progression. Therefore, targeting at periodontitis treatment and the γδ T-M2 immune mechanism might provide a new practical strategy for COPD prevention or control.IMPORTANCEPeriodontitis exacerbates chronic obstructive pulmonary disease (COPD) progression. For the first time, the current study identified that the impact of periodontitis on COPD progression was associated with the activation of γδ T cells and M2 macrophages and that M2 polarization of macrophages was affected by γδ T cells activation. The results indicated that targeting at periodontitis treatment and the γδ T-M2 immune mechanism might provide a new practical strategy for COPD prevention or control.
Patients will receive treatment by stabilized kilnman trio for four weeks (one application per day). Patient will receive 4 treatments by Dual yellow Laser on the hemi-face (side determinated by randomisation, split body study) at weeks 4, 6, 9 and 12.
The invention relates to a method of isolation of human mesenchymal stem cells (h MSCs) from wharton's jelly, which is the connective tissue of the umbilical cord (UC). The method comprises of deriving the cells and expansion of the cells in appropriate media for culture and maintenance of the cells. Further, the cells were induced to differentiate into oestocytes, chondrocytes and adipoctes, and pancreatic cells. The cells also displayed embryonic like characteristics as demonstrated by high expression of embryonic markers. The unique ability of these cells to form embryoid bodies like clusters (EB-LCs) having more propensity towards endoderm lineage (pancreatic lineage) as compared to undifferentiated mesenchymal stem cells. Hence from the in vitro characterization it is indicated that it can be a potential source of cells for regenerative therapies for pancreatic related disorders.
The invention discloses a kind of wherein double solvents method of active polysaccharide-araboxylan of extracting from wheat bran. This extracting method mainly comprises the steps: first to use weak acid (citric acid) mild hydrolysis pretreatment wheat bran; Use again highly basic (KOH) to extract target polysaccharide; Extract is through centrifugal, neutralization, concentrated and ethanol precipitation; Ethanol drying precipitate obtains target polysaccharide. Ethanol precipitation centrifuged supernatant can be used as agricultural composite fertilizer and is fully utilized after concentrate drying. The present invention utilizes this large accessory substance resource of wheat bran, has designed a kind of double solvents and has extracted this bioactive polysaccharide of araboxylan, and more traditional alkaline process has improved operating efficiency and alleviated environmental protection pressure. Zoopery shows that this polysaccharide has significant immunoregulatory activity, and effect may be compared with lentinan. The present invention relates to target polysaccharide cost of material cheap, aboundresources, extracting method is more green, environmental protection, and Mirae Corp.'s development prospect is wide.
This invention refers to the producing method for the composite medicine liq. containing rifamycin antibiotic. The method is carried out by dissolving the rifamycin antibiotic in the composite org. solvent comprising dimethyl sulphoxide, acetic ether and alcohol etc., adding additional liq. comprising antioxidant, metal ion complex, surface-active agent and pH buffer substances to obtain the product. The composite medicine liq may be produced in forms of injection liq., oral liq. and skin-penetrating liq. etc., its prepn is simple, the medicine liq. is stable and has good practiolity. It develops the medical applications of the rifamycin antibiotic and has the strong bactericidal power for varied pathogenic bacteria.
Eligible participants received a single subcutaneous injection of Placebo to Canakinumab. Patients must have had documented diagnosis of Type 2 Diabetes Mellitus and be on a stable dose of Metformin (Met) at least 1000 mg/day , and a Sulfonylurea (Sulfonyl), at least 1/2 the maximally labeled dose, and a Thiazolidinedione (Thiaz)at least 1/2 the maximally labeled dose combination therapy, for 3 months prior to screening.
Measures taken before and after the defined IF periods. Two groups of participants will be included in this project: 1) resistance trained group (tested for neuromuscular function, anaerobic capacity and body composition); 2) endurance trained group (tested for aerobic and anaerobic capacity and body composition). Experimental condition: pre- and post-4 weeks of IF. Measurements will be taken during the morning period (between 07:00 and 11:00 am) in the fasted state. Neuromuscular function and anaerobic capacity will be assessed on separate days (with at least a 48- hour interval) to ensure full recovery.
FIELD: medicine, pharmacy. SUBSTANCE: invention characterizes preparations for sustained delivery comprising water-insoluble complex of peptide compound (for example, peptide, polypeptide, protein, peptide mimetic agent and so on) and macromolecule-carrier. Compositions ensure to charge small volume of peptide compound of high concentration that provides prolonged delivery of pharmaceutically active peptide compound, for example, for one month after administration of complex. Complexes can be crushed or ground up to finely milled powder. In powder-like state complexes form stable aqueous suspensions and dispersions useful for injection. In preferable variant of realization the complex compound is presented by LHRH analogue, preferably LHRH antagonist, and macromolecule-carrier is an anionic polymer, preferably, carboxymethylcellulose. Invention describes also methods for preparing complexes corresponding to invention and methods of using complexes containing LHRH analogues for treatment of states treating with LHRH analogues. Invention provides therapeutic effectiveness of pharmaceutical composition, effectiveness of method and syringe. EFFECT: improved method of treatment. 54 cl, 3 tbl, 5 dwg, 14 ex
Weifuchun Treatment and mechanism on Gastric Cancer. Main Responsibility Person: Mingyu Sun research center#Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Trial Objective#Observe the clinical efficacy and mechanism of Weifuchun in the treatment gastric cancer Therapeutic Schedule#In this study, 72 patients with gastric cancer who received chemotherapy in the Department of Gastrointestinal Surgery and Oncology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were recruited and divided into groups according to random number table method, namely, 36 patients in the Weifichun combined chemotherapy group and 36 patients in the chemotherapy group alone. Weichun group was treated with 24 weeks of Chinese patent medicine Weichun tablet at the same time of chemotherapy. The physical status score, TCM syndrome score, quality of life score, bone marrow suppression and tumor index of the two groups before and 24 weeks after treatment were observed and compared.Fecal samples of the above patients before and after the entry and exit groups were collected, screened and submitted for examination. Finally, 15 cases were submitted for examination in the Weifichun combined chemotherapy group and chemotherapy group alone, and 10 cases were submitted for examination in the healthy volunteers. Miseq platform was used to conduct high-throughput sequencing and analysis of 16S ribosomal RNA of intestinal flora, fecal quality assessment of intestinal flora tested was conducted, α diversity and β diversity were analyzed, and the flora structure, including the level of taxonomy, family, genus, etc., were compared to analyze the differences in each group, and elucidate the possible mechanism of action of Weichun in the treatment of gastric cancer patients.
Glycopyrronium bromide 50µg delivered once daily via Single Dose Dry Powder Inhaler (SDDPI). At visit 1 all patients were provided with a short acting β2-agonist (salbutamol/albuterol) which they were instructed to use throughout the study as rescue medication.
The present invention relates to a composition for skin external application, containing a cell culture product of Neofinetia falcata (Thunb. ex Murray) Hu or an extract thereof. More specifically, the present invention relates to a composition for skin external application for strengthening skin barrier function, containing a cell culture product of Neofinetia falcata (Thunb. ex Murray) Hu or an extract thereof as an active ingredient. According to the present invention, the composition for skin external application containing the cell culture product of Neofinetia falcata (Thunb. ex Murray) Hu or the extract thereof is not toxic to skin cell and shows excellent capability of synthesizing skin collagen. In addition, the composition also exhibits capabilities of improving and ameliorating skin elasticity due to an increase in the elastase expression, clearing skin, and protecting, strengthening, and ameliorating skin barrier function.
Placebo Subcutaneous (SC) injections every 4 weeks (wks) thru Wk 20 (unless early escape at Wk 16); Golimumab - if early escape, 50 mg SC injections from Wk 16 up to 5 yrs; Golimumab - 50 mg SC injections beginning Wk 24 up to 5 yrs (unless early escape); Golimumab - Dr's discretion after unblinding, dose adjusted from 50 to 100 mg and from 100 to 50mg. Duration of the blinded period will be until the week-24 database lock.
One example embodiment relates to a method of increasing bioavailability of silybin in a person. The method includes providing silybin and a flavonoid to 5 the person, wherein the flavonoid is tangeretin or baicalein. Another example embodiment relates to a method of treating chronic liver disease in a person by administering silybin and a flavonoid to the person to treat the chronic liver disease. -I -- h) aQ 0 <. (DO 0. w w w "oO LT 0.)CC -h -0. -0 0 CD : --h
Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by hyperglycemia resulting from the destruction of insulin-producing β-cells that is traditionally deemed irreversible, but partial remission (PR) with temporary reversal of hyperglycemia is sometimes observed. Here we use single-cell RNA sequencing to delineate the immune cell landscape across patients in different T1D stages. Together with cohort validation and functional assays, we observe dynamic changes in TIGIT+CCR7- Tregs and CD226+CCR7-CD8+ cytotoxic T cells during the peri-remission phase. Machine learning algorithms further identify TIGIT+CCR7- Tregs and CD226+CD8+ T cells as biomarkers for β-cell function decline in a predictive model, while cell communication analysis and in vitro assays suggest that TIGIT+CCR7- Tregs may inhibit CD226+CCR7-CD8+ T cells via TGF-β signaling. Lastly, in both cyclophosphamide-induced and streptozotocin (STZ)-induced mouse diabetes models, CD226 inhibition postpones insulitis onset and reduces hyperglycemia severity. Our results thus identify two interrelated immune cell subsets that may serve as biomarkers for monitoring disease progression and targets for therapeutic intervention of T1D.
This study will follow a group of individuals with carpal tunnel syndrome (CTS) according to Bland's grading scale (grades 1-3) to assess the role of inflammation in CTS. Participants will undergo clinical and biochemical evaluations to assess inflammatory markers and CTS severity. The study will follow participants over time to determine the relationship between inflammation and CTS, which can inform the choice of transdermal drug administration.
This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression and amenability to treatment therapies. Diagnostic methods include a method for predicting long term non-progression in an HIV-infected subject. Preventative and treatment methods encompass determining whether a subject exhibits or can exhibit an HLA-Cw7-restricted CTL response. They also encompass ways of eliciting such a response, if necessary. Furthermore, some of the methods involve administering one or more HIV polypeptides or peptides, or polynucleotides encoding them, as a treatment therapy to prevent the development of AIDS.
PURPOSE: EEG reactivity (EEG-R) has become widely used in intensive care units for diagnosing and prognosticating patients with disorders of consciousness. Despite efforts toward standardization, including the establishment of terminology for critical care EEG in 2012, the processes of testing and interpreting EEG-R remain inconsistent.
METHODS: A review was conducted on PubMed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria consisted of articles published between January 2012, and November 2022, testing EEG-R on adult intensive care unit patients. Exclusion criteria included articles focused on highly specialized stimulation equipment or animal, basic science, or small case report studies. The Quality In Prognostic Studies tool was used to assess risk of bias.
RESULTS: One hundred and five articles were identified, with 26 variables collected for each. EEG-R testing varied greatly, including the number of stimuli (range: 1-8; 26 total described), stimulus length (range: 2-30 seconds), length between stimuli (range: 10 seconds-5 minutes), frequency of stimulus application (range: 1-9), frequency of EEG-R testing (range: 1-3 times daily), EEG electrodes (range: 4-64), personnel testing EEG-R (range: neurophysiologists to nonexperts), and sedation protocols (range: discontinuing all sedation to no attempt). EEG-R interpretation widely varied, including EEG-R definitions and grading scales, personnel interpreting EEG-R (range: EEG specialists to nonneurologists), use of quantitative methods, EEG filters, and time to detect EEG-R poststimulation (range: 1-30 seconds).
CONCLUSIONS: This study demonstrates the persistent heterogeneity of testing and interpreting EEG-R over the past decade, and contributing components were identified. Further many institutional efforts must be made toward standardization, focusing on the reproducibility and unification of these methods, and detailed documentation in the published literature.
Triazolo pyrimidines of formula(I) and their acid addn. salts are prepd.  by the condensation of II and R2-C(OR)3.  In the formula, x is pyridyl opt. substd. by C1-4 straight or branched alkyl or alkoxy, OH, or CN; R is Me or Et; R1 is H; R2 is straight or branched C1-4 alkyl.  Treatment of cardiac insufficiences rhythmic disorders, and cardiac weakness.  The cpds. showed no signs of casuing toxic symptoms in tests on mice, rats, and rabbits(details not. given)
Participants received amcenestrant 200 mg tablet along with letrozole-matching placebo once daily, continuously and palbociclib 125 mg PO, QD from Day 1 to Day 21 of each 28-day treatment cycle until disease progression, death, or study cut-off date, whichever comes first (maximum exposure: 109 weeks). Goserelin once every 4 weeks in pre/peri menopausal women and men.
Voluntary self-exclusion is a program used by people who seek to bar themselves from further access to the casino or other gambling venue. Currently there are over 10000 people in the program. Although some self-exclusion programs place a permanent ban on the individual, others offer the possibility of reinstatement after a period of time. Many problem gamblers actually do change their minds about self-exclusion and wish to return to gambling. Centre for Addiction and Mental Health (CAMH), in cooperation with Ontario Lottery and Gaming (OLG), is developing a tutorial designed to provide practical information to players who choose to reinstate and return to gambling. The goal of this study is to evaluate an the intervention to determine its impact on problem gamblers who is reinstated from relapsing to problematic levels of gambling. The content for the tutorial will be informed by CAMH, will be developed for land based gambling, and also adapted for online gambling as well.
BACKGROUND: Measures of systemic inflammation (MSIs) have been developed and shown to help predict prognosis in patients with lung cancer. However, studies investigating the impact of MSIs on outcomes solely in cohorts of patients undergoing curative-intent resection of NSCLC are lacking. In the era of individualized therapies, targeting inflammatory pathways could represent a novel addition to the armamentarium of lung cancer treatment.
METHODS: A multicentre retrospective review of patients who underwent primary lung cancer resection between 2012 and 2018 was undertaken. MSIs assessed were neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune inflammation index (SII), advanced lung cancer inflammation index (ALI), prognostic nutritional index (PNI) and haemoglobin albumin lymphocyte platelet (HALP) score. Cox regression analysis was performed to assess the impact of MSIs on overall survival.
RESULTS: A total of 5029 patients were included in the study. Overall 90-day mortality was 3.7% (n = 185). All MSIs were significantly associated with overall survival on univariable analysis. After multivariable Cox regression analyses, lower ALI (expressed as a continuous variable) (HR 1.000, 95% CI 1.000-1.000, P = .049) and ALI <366.43 (expressed as a dichotomous variable) (HR 1.362, 95% CI 1.137-1.631, P < .001) remained independently associated with reduced overall survival.
CONCLUSIONS: MSIs have emerged in this study as potentially important factors associated with survival following lung resection for NSCLC with curative intent. In particular, ALI has emerged as independently associated with long-term outcomes. The role of MSIs in the clinical management of patients with primary lung cancer requires further investigation.
The present invention discloses medicine for treating gastropathy, which is Chinese patent medicine which comprises the raw materials of the weight proportion: 160 to 240 portions of Chinese aralia, 14 to 21 portions of Jiuyuesheng and 6.5 to 9.5 portions of pseudostellaria roots and is prepared according to a conventional method. The present invention is the medicine prepared according to the medicine theory of the nationality of Miao. The medicine can promote gastric motility, accelerate the emptiness of gastric contents, reduce contact time between gastric acid and stomach proteinase, and ulcer surfaces, reduce the amount of bile returning into a stomach, reduce mechanical stimulation to gastric antrum parts from the gastric contents, reduce gastrin release and promot the growth of epithelial cells and tissues. Thereby, the function of canker resistance is exerted. The medicine has the functions of eliminating coldness, stopping pain stop and replenishing qi to invigorate spleens and is used for deficiency coldness in middle JIAO, gastric cavity pain and pregnant press. The medicine can be used for treating patients with symptoms of stomach and duodenal ulcers and chronic gastritis. The medicine has the characteristics of easy preparation, low cost and good therapeutic effect.
To achieve maximum contraceptive effectiveness, norethindrone acetate and ethinyl estradiol tablets and ferrous fumarate tablets must be taken exactly as directed. Instruct patients to take one tablet by mouth at the same time every day. The tablet may be chewed and swallowed or swallowed whole. The patient should drink a full glass (8 ounces) of water immediately after the white tablets are chewed or swallowed whole. Tablets must be taken in the order directed on the blister pack. Tablets should not be skipped or taken at intervals exceeding 24 hours. For patient instructions for missed tablets. Norethindrone acetate and ethinyl estradiol tablets and ferrous fumarate tablets may be administered without regard to meals [see Clinical Pharmacology (12.3)].
PURPOSE: The manufacturing method of an artificial tooth is provided to reduce a manufacturing process and to prevent the damage of a tooth model. CONSTITUTION: An injection line for injection of resin is formed. Silicon is spread in the outside of a tooth model in which the injection line is formed and a silicon frame is formed. The silicon frame is separated when the silicon is hardened. Wax is removed using hot water. A tooth is fixed to the silicon frame. The tooth model combined in the silicon frame. Resin is inserted in the silicon frame.