anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: This study investigates if countries are more focused on certain specializations (one day, climb, sprint, time trial [TT] and grand tour [GC]) in male professional road cycling and if this is possibly linked to the countries landscape (for example, does a mountainous country have more climbers?) and anthropometric characteristics (does the mountainous country also have lighter cyclists?) of their cyclists.
METHODS: Body weight, height, procyclingstats (PCS) points per specialty were gathered from 1810 professional cyclists out of 15 countries, as well as the elevation span of those countries. To compare the anthropometric differences between different countries, height was normalized based on the average height of the countries' population, while BMI was used as a correction for body weight.
RESULTS: The average anthropometrics (body weight and height) of professional cyclists in a country are related to the relative number of PCS points collected in GC, sprint and climb races. This means that when a country has shorter and lighter cyclists, they score relatively better in GC and climb races and vice versa for sprint races, which indicates that countries are focused on certain specialties. However, these relationships were not found for TT and one day PCS points. In addition, countries with larger cyclists have a less mountainous (elevation span) landscape compared to countries with lighter cyclists.
CONCLUSIONS: The results suggest a selection bias towards smaller/lighter or taller/heavier cyclists in various countries, probably caused by the terrain of their home country, leading to missed opportunities for some cyclists to reach professional level.
The invention provides a drug composition for preventing and/or treating gynecological diseases and a preparation method of the drug composition. The drug composition comprises tea seed total glycosides and an extractive obtained by extracting golden cypress, golden larch bark and radix sophorae flavescentis water/ethanol solution, the ratio of the tea seed total glycosides to the extractive is 1:5-5:1(the golden cypress to the golden larch bark to the radix sophorae flavescentis is (1-5):(1-5):(1-5)), and the extractive has tea seed glycosides, berberine, pseudolaric acid and radix sophorae flavescentis alkali characteristic peaks after analyzed by using a chromatography. The drug composition can be used for an external preparation for preventing and/or treating the gynecological diseases. In addition, the invention further provides the preparation method of the drug composition. The method is simple, economic, and suitable for enterprises with conventional traditional Chinese medicine production equipment and without additional special equipment. Tests on animals and human bodies show that the prepared external preparation has a remarkable pharmaceutical effect and is high in safety.
An integrated exercise routine consisting of 8 purposeful movement forms and a set of therapeutic movements. Participants attend a supervised, group-based tai ji quan program remotely where they perform an integrated exercise routine consisting of 8 purposeful movement forms and a set of therapeutic movements 3 times per week for 60 minutes per session.
Limited data are available in regard to edex® overdose in humans. Systemic reactions are uncommon with intracavernous injection of edex®. Hypotension occurred in less than 1% of patients treated with edex®. A single dose rising tolerance study in healthy volunteers indicated that single intravenous doses of alprostadil from 1 to 120 mcg were well tolerated. Beginning with a 40 mcg bolus intravenous dose, the frequency of drug-related systemic adverse events increased in a dose-dependent manner, characterized mainly by facial flushing.

The primary symptom of an edex® overdose is a prolonged erection or priapism. Because of the potential for tissue hypoxia and possible necrosis, it is strongly recommended to treat an erection lasting more than 6 hours. The patient is strongly encouraged to go to the nearest emergency room if his personal physician is not available.

In the event of an overdose, supportive therapy according to the presence of other symptoms is recommended.
The experimental group will receive access to SMART online platform (6 weeks). SMART includes mental and physical wellness, residual/prosthetic limb managements, use of a prosthesis and weekly peer-support calls or video call over Zoom, hosted by University of British Columbia, depends on participant's preference, promoting motivation and establishing goal setting and action planning. SMART will also allow asynchronous contact with trainers through a secure website.
This project aims to develop and pilot test a combined economic and relationship-strengthening intervention to redirect funds spent on alcohol into financial investments (e.g., education, income-generating business) and to improve couple relationships and adherence to ART. The study hypothesizes that engaging couples to work together on alcohol use and financial goals-equipped with financial, communication, and problem-solving skills-will decrease alcohol use, and improve relationship dynamics and adherence to ART. Specifically, the project aims: (1) to adapt and integrate two proven interventions, Suubi and Uthando Lwethu, using the ADAPT-ITT method, into a combined intervention for HIV-affected couples with a heavy alcohol user (to be called Mlambe); (2) to develop and pilot test the study procedures to evaluate Mlambe; and (3) to assess the feasibility and acceptability of Mlambe through a pilot study. In the formative phase, the study will develop a draft of the intervention manual and conduct five focus group discussions with couples and key stakeholders to obtain input on the intervention. In the pilot phase, 80 HIV-affected couples with a heavy alcohol user will be enrolled and randomized to either Mlambe or the comparison arm (regular HIV care plus brief advice on alcohol use). The study will conduct qualitative interviews with a subset of 20 couples to contextualize feasibility and acceptability data, and then will analyze the mixed- methods feasibility and acceptability data to refine intervention and procedures for a future trial.
PURPOSE:A bronchial vasodilator, containing a benzo-gamma-pyrone derivative as an active constituent, administrable orally in the form of a pharmaceutical, e.g. tablet or capsule, or parenterally in the form of a germ-free solution, etc., and useful for treating bronchial asthma. CONSTITUTION:A bronchial vasodilator containing a benzo-gamma-pyrone derivative of the formula (R<1> and R<2> are lower alkyl group; X and Y are H or together may represent direct bond) as an active constituent. A 7-alkoxy-3-alkylchromanone is used when X and Y are H in the benzo-gamma-pyrone derivative to be used as the active constituent, and a 7-alkoxy-3-alkylchromone is used when X and Y together represent direct bond. The dose for treatment is within 20- 500mug range active constituent administered in several portions. In formulation, a vehicle, carrier, excipient, binder, etc. are incorporated with the active constituent.
BACKGROUND: Complex regional pain syndrome is a neuropathic pain disorder associated with ongoing pain that persists beyond the usual expected tissue healing time and that is disproportionate to the degree of tissue injury present. Complex regional pain syndrome after hip arthroscopy has not been reported before. Hip arthroscopy is a fast-growing domain that could lead to an increasing number of complex regional pain syndrome cases, probably owing to the high traction forces that are necessary.
CASE PRESENTATION: We report the case of a 30-year-old German female semiprofessional tennis player who presented with complex regional pain syndrome type I in the lower leg 3 weeks after hip arthroscopy for femoroacetabular impingement syndrome with suture anchor labral repair and femoroplasty. After 2 months of immediate multimodal conservative therapy including administration of gabapentin, prompt full weight-bearing, and intensified physiotherapy, complete recovery was achieved.
CONCLUSION: Complex regional pain syndrome does occur after elective hip arthroscopy. Disproportionate postoperative pain or other symptoms raising suspicion of complex regional pain syndrome should be promptly evaluated and treated through a multimodal approach. Postless hip arthroscopy may be advantageous.
The present invention discloses a drug tincture for treating flat wart and a preparing method thereof. According to the weight proportion, the present invention is made of materials: 30 to 10 portions of radix isatidis, 30 to 10 portions of kuhseng, 30 to 10 portions of asket fern, 30 to 10 portions of cortex dictamni, 30 to 10 portions of dahurian angelica, 30 to 10 portions of fructus cnidii selinum, 30 to 10 portions of rhizoma sparganii, 30 to 10 portions of zedoary, 30 to 10 portions of red peony root, and 1200 to 400 portions of alcohol with the concentration of 75%. The present invention has the preparing method that the radix isatidis, the kuhseng, the asket fern, the cortex dictamni, the dahurian angelica, the fructus cnidii selinum, the rhizoma sparganii, the zedoary and the red peony root are taken out 30 to 10 portions to be soaked for 10 days by the 1200 to 400 portions of the alcohol with the concentration of 75%, and dregs of the drugs are filtered to obtain filter liquors, namely the drug tincture. The present invention has the advantages that the drug tincture is a pure external application tincture for the traditional Chinese medicine, viruses can be killed fast, the wart is removed, and the junction is diffused. Besides, the present invention has the advantages of obvious curative effect, easy use and no side effect. Except for persons who are allergic to the alcohol, the present invention has basically no irritation at skins.
BACKGROUND: Neurofibromas are benign peripheral nerve sheath tumors usually featured with neurofibromatosis type 1 syndrome. Recurrent gingival neurofibromas have been rarely reported in the periodontal literature, particularly affecting elderly patients.
METHODS AND RESULTS: A 70-year-old man with a pale, rubbery, and painless thickening along the facial/buccal gingiva of the mandibular right canine and first premolar. Ten years prior, the patient had undergone excision of a neurofibroma within the same region. The patient denied a history of cutaneous disease or neurofibromatosis. Histopathologic and immunostaining of the excised lesion confirmed the diagnosis as a recurrent gingival neurofibroma.
CONCLUSIONS: With cases of suspected recurrent neurofibroma, attending practitioners should consult with an oral pathologist whether the primary lesion had exhibited tumor cells to the surgical specimen margin. Preoperative use of a cone beam computed tomography scan may enhance determination of tumor depth. Clinicians should also carefully weigh the decision for conservative excision of gingival neurofibromas and greater risk of recurrence versus performing a somewhat wider extirpation and possible formation of a mucogingival defect.
KEY POINTS: What are important clinical considerations when performing a gingival biopsy? Gingival neurofibromas may be associated with an increased risk for recurrence owing to decisions for tissue-sparing excision and prevention of a mucogingival defect; supplemental use of cone beam computed tomographic scans may provide greater appreciation of tumor depth. What is a reasonable length of time of postoperative assessment for gingival neurofibromas? Patients who have undergone surgical removal of a gingival neurofibroma should undergo yearly surveillance for at least 10 years. What is a key limitation to this case study? Preoperatively, attending clinicians should consult with an oral pathologist to ascertain whether a primary lesion had manifested tumor cells to the surgical margin. Conservative gingival resection of a neurofibroma may promote recurrence.
Hot flush (HF) is the most common symptom among menopausal syndrome and can significantly affect women's quality of life. Considering the risk of hormone therapy, the behavioral therapies have been proposed for the alternative treatment of HF. However, the exercise prescription for women with HF is controversial. Previous studies show the inconsistent effect of aerobic exercise on HF, and a moderate-to-high intensity exercise seems to aggravate HF frequency and severity. Recent studies have shown that static stretching exercise could improve HF in middle-aged women, but the related research is quite few, and the physiological mechanism as well as predictors for responders who can benefit from stretching exercise are still not clear. The knowledge of predictors for responders will provide clinicians and clients with HF symptoms to choose static stretching exercise as their treatment.
FIELD: cosmetics. SUBSTANCE: invention relates to cleansing and tonic lotion. Tonic face lotion has biologically active plant extracts from mint, celandine, matricary, rosemary, pot-marigold, marjoram prepared in dry wine, alcohol-containing components, for example, alcoholized natural juices of grapefruit, apple, strawberry and cherry, salicylic acid, diazolidinylurea or 2-bromo-2-nitropropane-diol-1,3 and perfume. Tonic lotion produces cleansing, tonic, antiinflammatory and antiseptic effects, prevents processes of face aging. EFFECT: enhanced effectiveness of lotion, improved properties. 1 tbl
Titanium alloy plates are frequently used materials in our current orthopedic surgery practices. The main goal during surgical treatment is to obtain an accurate and acceptable bone alignment. Achieving this goal as soon as possible will reduce additional morbidity and mortality and increase the success of treatment. Therefore, studies aiming to reduce the operation time come to the fore. When the literature is examined, there are limited number of studies on carbon plates. In these studies, it was reported that similar functional results were obtained with titanium alloy plates. Although the bones are at the surgeon's disposal in plate fixation of radius distal end fractures, fluoroscopy is frequently used for reduction control. The increase in the need for scopy both directly affects the duration of the operation and causes the surgical team to be exposed to excessive radiation. Since titanium alloy plates are radiopaque, they create a superposition to the fracture line and more than one view is usually required in each plane to ensure the reduction quality during surgery. Carbon alloy plates, on the other hand, offer the advantage of faster radiological reduction control because they do not create superposition to the fracture line. In our study, in addition to the comparisons in the literature, it is aimed to investigate the effect of carbon plates on the procedure time. For this purpose, distal radius fractured patients applied to our clinic will be treated with titanium and carbon plates after the necessary randomization. After the tourniquet is applied, the time elapsed until the fixation is completed, the duration of scopy, and the number of scopy images taken will be recorded. In the follow-ups, the functional scores and radiological measurements of the patients will be made and the complications will be evaluated.
PURPOSE: Phimosis is a common condition of the urinary system in children and often requires surgical treatment. However, the optimal method of circumcision for children has not been determined. We conducted a systematic review and meta-analysis to compare the safety and effectiveness of plastic clamp with conventional surgical circumcision in pediatric circumcision.
METHODS: A literature search was carried out to compare the plastic clamp and conventional dissection technique in the pediatric population. The following search terms were used: "circumcision", "plastic clamp", "conventional", "plastibell", "children" and etc. Meta-analysis was used to pool and evaluate variables such as operative time, blood loss, wound infection, bleeding, edema, and total postoperative complications.
RESULTS: The plastic clamp technique (PCT) was used in 10,412 of the 17,325 participants in the nine studies, while the conventional surgical dissection technique (CST) was used on 6913 patients. When compared to the CST approach, the PCT approach resulted in shorter operative times (mean difference (MD) -17.48, 95% CI -22 to -12.96; P < 0.001), less blood loss (MD -4.25, 95% CI -7.75 to -0.77; P = 0.02), and a higher incidence of postoperative edema (OR 2.33, 95% CI 1.34 to 4.08; P = 0.003). However, no significant difference was found in the incidence of postoperative complications, including wound infection and bleeding between PCT and CST.
CONCLUSIONS: PCT is a safe and time-saving option in the pediatric population. However, this method appeared to have a significant greater rate of postoperative edema.
INTRODUCTION: Pembrolizumab is a humanized monoclonal antibody IgG4 programmed cell death protein 1 antagonist, and its use in oncology has been increasing in recent years, providing durable and favorable responses and tolerable toxicity profiles in various types of cancer. We describe a case of pembrolizumab related perforated appendicitis in a patient with stage 3C malignant melanoma (MM).
CASE REPORT: A 70-year-old male patient who had no known disease was diagnosed with MM as a result of the excision of the mass on his right shoulder. The disease stage was stage 3C (pT4aN1bM0). Subsequently, adjuvant pembrolizumab treatment was started. A few days after the fourth maintenance course, he presented to the emergency department complaining of abdominal pain, nausea and vomiting. Emergency abdominal tomography showed a significant increase in the diameter of the appendix vermiformis, peritoneal thickening and appendiceal wall defects that could be significant in terms of perforation.
MANAGEMENT AND OUTCOME: The mentioned finding and given the clinical presentation, was attributed to a perporating of the appendix, so the patient was hospitalized in the Department of Surgery and the patient underwent emergency appendectomy. Histological findings were consistent with appendicitis. After a day in the hospital, the abdominal pain subsided, C-reactive protein tended to decrease and the patient was discharged.
DISCUSSION: In patients who develop acute abdominal pain with or without diarrhea during immunotherapy, urgent imaging, endoscopic and clinical evaluation should be performed, and bowel perforation, although rare, should be considered as a potential complication of any immunotherapy.
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4,000 milligrams per day, and often involve more than one acetaminophen- containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products. 

The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen. 

Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than 4,000 milligrams of acetaminophen per day, even if they feel well.
The long-term goal of this proposal is to improve treatment outcomes for OEF/OIF(Operation Enduring Freedom/Operation Iraqi Freedom) veterans with alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) who are not currently accessing care through the Veterans Affairs Healthcare System (VA) or other settings. Many OEF/OIF veterans struggle with heavy drinking and related consequences and this can be especially pronounced with the co-occurrence of PTSD. Prior research has found aspects of self-regulation (emotion regulation, impulse control), stress, and craving to be important putative targets in AUD and PTSD symptom reduction. However, with upwards of 50% of veterans who have behavioral health needs not seeking treatment, it is imperative to utilize advances in technology to develop and test interventions that can reach non-treatment seeking veterans and target both symptoms of PTSD and AUD. As the proposed mechanisms (e.g., self-regulation) are becoming better understood regarding how they affect PTSD and AUD outcomes, approaches should focus on targeting these mechanisms and evaluating if they are essential facilitators of change. Mindfulness-based interventions (MBI) can target such mechanisms, but a gap in the knowledge persists regarding the utility of MBIs with veterans who screen positive for PTSD and AUD. Therefore, we propose to improve treatment outcomes for OEF/OIF veterans with PTSD and AUD by targeting self-regulation, stress, and cravings. We will develop and test a novel mobile MBI, Mobile Mindfulness Based Relapse Prevention (mMBRP), that will improve upon evidence based in-person and group MBRP by reaching veterans outside of treatment settings. The engaging and easy to use mobile MBI integrates relapse prevention, stress reduction, and self-regulation skills and is relevant to issues surrounding stigma and barriers that veterans face when seeking services. The central hypothesis will be tested through a focus on three specific aims: (1) refine and add MBRP content to the popular VA developed Mindfulness Coach mobile application through a beta testing phase where we test for feasibility and acceptability of the app, (2) pilot test the efficacy of the mMBRP mobile app on alcohol use and PTSD outcomes compared to control, and (3) assess mechanisms of change such as self-regulation, stress, and cravings, as well as exploratory moderators of gender, race/ethnicity, and recency of discharge, on mMBRP effects. The unique strengths of this proposal are its focus on an underserved population, utilization of mobile technology for intervention delivery, and use of a novel intervention known to effectively target self-regulation and stress. The expected results will define a viable and easy-to-access treatment that can improve both AUD and PTSD symptoms. Results of this study will have a positive impact on substance use outcomes for those who have experienced traumatic events and will identify mechanism of action for treatment success. The app can be disseminated through our partners in the VA and through targeted sharing on social media.
Embodiments include a system including a sealed prefilled drug-reservoir. The drug-reservoir may include a unit dosage of treprostinil in a sterile fluid composition. The composition may not include an antimicrobial preservative. The treprostinil may be present at a dosage of between 0.1 mg/mL and 25 mg/mL. In addition, the treprostinil may be treprostinil sodium Furthermore, the composition may include sodium chloride. The composition may also include a sodium ion from sodium chloride in a concentration from 3000 to 4500 ppm. The composition may not include metacresol.
This disclosure relates generally to treatment management systems, which may include a clinical database for storing therapeutic protocols. The system may also include a treatment engine operatively connected to the clinical database. The treatment engine may obtain diagnostic information and select a first plurality of therapeutic protocols from the clinical database based on the obtained diagnostic information and reference protocol data. The treatment engine may calculate a treatment efficacy probability for each protocol using the reference protocol data. The treatment engine may develop a first treatment plan and evaluate intermediate data indicating an altered patient state due to the first treatment plan. The treatment engine may select, based on reference protocol data and adaptive protocol data, a second treatment plan using a second plurality of therapeutic protocols. The selected second treatment plan is adapted based on the clinical objective, the reference protocol data, and the treatment efficacy information.