anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A non-woven wet wipe product ( 22 ) comprising a sheet member, for use with a wet wiping agent ( 32 ), ( 18 ), the product comprising a segment of a non-woven self-supporting web ( 150 ) comprised of an assemblage of fibers including synthetic thermoplastic fibers and absorbent or adsorbent fibers, the non-woven web ( 150 ) being in a permanent, dry-creped, heat-set condition defining a succession of ridges ( 24 ) and grooves ( 26 ) in the overall body ( 30 ) of the web, the constituent thermoplastic fibers of the sheet member having been heat-set simultaneously during the imparting of the ridges and grooves to the web, the heat-set condition of the dry-creped thermoplastic fibers preserving the ridge and groove configuration during prolonged presence in the web of the wet agent ( 32 ). The wet wiping agent can be initially, prewet in the packaging, with liquid disposed through the body and on the surface of the dry-creped, heat-set sheet-form member and its constituent fibers. In this case, the product is packaged in a stack within a liquid tight container. In another case the wipes are packaged dry to be wet by the user. Methods for making the products are also disclosed. Whereas advantageous embodiments are formed by hydro entanglement, other embodiments are formed using other non-woven forming processes, including wet-laid techniques, etc.
Screening of people with breast tumors, through breast color Doppler ultrasound examination, the results showed that there is only a single tumor on either side of the breast. The computer tomography photoacoustic breast imaging system was used to perform breast examination again. By comparing ultrasound and photoacoustic vascular imaging, the vascular imaging of the computer tomography photoacoustic breast imaging system developed by Union Photoacoustic technologies Co., Ltd was evaluated.

This test does not evaluate the diagnosis or treatment performance of two imaging modalities. It only compares the vascular imaging of two different imaging systems. Therefore, the evaluation index of this experiment is the percentage of blood vessel pixel number in the same region of interest (ROI) to the total pixel number in ROI. By comparing the percentages of blood vessel pixel number to the total pixel number in the same ROI in ultrasound and computerized tomography photoacoustic breast imaging system, the vascular imaging of the computerized tomography photoacoustic breast imaging system is evaluated.
The invention discloses a Poria cocos extract. The content of pachymaran and Poria cocos triterpene in the Poria cocos extract is 55-95wt%. A preparation method of Poria cocos extract comprises the following steps: crushing Poria cocos, sieving, and proportionally mixing with ethanol; carrying out microwave extraction in a microwave extraction device; and filtering through a micro-porous filtering film, abandoning filter residues, and mixing the above filtrates to obtain a liquid Poria cocos extract, or concentrating the filtrates and drying to obtain a solid Poria cocos extract. The invention also discloses the preparation method of the Poria cocos extract. The method has the advantages of mild extraction conditions, fast speed, small application amount of a solvent, good selectivity, simple operation and the like. The Poria cocos extract prepared in the invention is from a traditional Chinese medicine, has the advantages of remarkable effects and high safety factor, has bacterium preventing, inflammation eliminating, high moisturizing, oil secretion regulating, immunity enhancing, oxidation resisting, aging resisting and allergy resisting effects, can be used in health foods and beverages, pharmaceuticals and cosmetics, and enlarges the application value of Poria cocos.
PURPOSE: New catch derivatives are developed, which comprise azomethine-carboxyl acid, azobenzene-carboxyl acid, benzhydrazon, aminobenzoic acid and amino acid or dipeptides, pyrrolidine and/or oxazolidine carboxyl acid and formylcarboxymethyloxime act as structural elements, act as siderophore, and can be used in the form of their conjugates with active ingredients such as antibiotics to improve the anti-bacterial effectiveness of bacterial cells. CONSTITUTION: New catch derivatives are shown as formula (I), wherein azomethine-carboxyl acid rests, azobenzene-carboxyl acid rests, benzhydrazon rests, aminobenzoic acid rests and amino acid rests or dipeptides, pyrrolidine and/or oxazolidine carboxyl acid rests and formylcarboxymethyloxime rests act as structural elements. The compounds act as siderophors in gram-negative bacterial strains, in particular in pseudomonas and strains of E. coli, salmonella, klebsiella and proteus, and can be in the form of their conjugates with active ingredients, e.g. antibiotics (as "siderophore-antibiotic conjugates"), inject the latter into bacterial cells to improve or extend the anti-bacterial effectiveness of the cells, partly also for bacterial strains that are resistant to other beta-lactams. Also the compounds are suitable for using as iron chelating agents for illnesses related to disruption of the iron metabolism. In the formula (I), R1 = OH or Acyl and R2 in third and/or fourth position means aromatic azomethine-carboxyl acid rests or azobenzene-carboxyl acid rests, benzhydrazon rests, aminobenzoic acid rests and amino acid rests, pyrrolidine and/or oxazolidine carboxyl acid rests and formylcarboxymethyloxime and/or conjugates with active ingredients, in particular antibiotics. The compounds can be free acids in the form of their salts or esters that can be cleaved easily.
Use of Calcipotriene Topical Solution, 0.005% (Scalp Solution), may cause transient irritation of both lesions and surrounding uninvolved skin. If irritation develops, Calcipotriene Topical Solution, 0.005% (Scalp Solution), should be discontinued. 

For external use only. Keep out of the reach of children. Always wash hands thoroughly after use. 

Reversible elevation of serum calcium has occurred with use of topical calcipotriene. If elevation in serum calcium outside the normal range should occur, discontinue treatment until normal calcium levels are restored.
Embodiments of the application involve a formulation of Fluticasone Propionate in the form of a suspension, gel or dry powder comprising Fluticasone Propionate, Fluticasone Furoate, Micronized Fluticasone Propionate or Micronized Fluticasone Furoate or other corticosteroids. Additional pharmaceutical components of the formulation may allow for the adherence and duration of the active ingredient to the inflamed esophageal tissues. The resulting medication formulation is then targeted with a drug delivery device and applied directly to the oropharynx bypassing the oral cavity altogether. The medication then flows down the back of the throat to the esophagus. By passing the oral cavity prevents the corticosteroid drug from being absorbed into the bloodstream through oral cavity tissues, helping to prevent harmful side effects. Additional side effects are avoided by using the medication Fluticasone, which exhibits exceptionally low gastrointestinal absorption.
BACKGROUND: ICU patients are particularly susceptible to vitamin D3 deficiencies. This can be due to the severity of their underlying disease, the type of treatment they are on, and malnutrition before and inadequate nutrition during the hospitalization preceding ICU admission as well as advanced age. Literature provides no guidance on how to supplement vitamin D3 in severely deficient patients who are undergoing continuous renal replacement therapy (CRRT). Most serum 25(OH)D3 is bound with vitamin D binding protein in a complex whose molecular weight is 10 kDa. This means it can be removed during CRRT via convection mechanism. Critically ill patients undergoing CRRT can therefore be particularly prone to develop severe vitamin D3 deficiency.
METHODS: As the trial design, a randomized controlled, single blinded, multicenter, parallel group approach was chosen to compare a single administration of 750,000 IU of vitamin D3 via the enteral or oral route in ICU patients with severe vitamin D3 deficiency (measured serum 25(OH)D3 levels ≤ 12.5 ng/ml) undergoing CRRT with a single administration of 500,000 IU of vitamin D3. The trial will be performed in up to five university hospitals in Poland. The primary outcome is the percentage of patients that achieved serum 25(OH)D3 levels ≥ 30 ng/ml on days 3 and 7 following vitamin D3 administration. Assuming a drop-out rate of approximately 10%, the number of recruited patients should be 138.
DISCUSSION: Considering the potential pathophysiological mechanisms underlying hypovitaminosis D in critically ill patients under CRRT, it seems conceivable that these patients will require greater supplementation doses to correct severe deficiency. The study is meant to help answer the question whether increasing the supplementation dose by 50% will ensure a more effective replenishment of vitamin D3 in critically ill patients undergoing CRRT.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05657678, registered: December 12 2022, https://clinicaltrials.gov/study/NCT05657678?cond=NCT05657678&rank=1 .
Patients will undergo CYP2D6 genotyping, with results entered into the medical record to assist the physician with prescribing pain medication. In addition, a pain assessment questionnaire will be administered at baseline and 3 months.
<P>PROBLEM TO BE SOLVED: To provide a composition and a method for improving stability and retention of an RNA in blood.  <P>SOLUTION: The composition for administering the RNA into the blood comprises a complex of a carrier having, as a side chain, a hydrophilic group bound to a polycationic compound in a comb-like form and the RNA. The polycationic compound is preferably a poly(cationic amino acid). The excretion of the RNA from the kidney is inhibited and the retention of the RNA is improved. For example, the treatment of cancer can be effected by administering an siRNA (a small interfering RNA) having therapeutic effects on the cancer into the blood. For example, PLL-Dex (poly-L-lysine-g dextran) or PLL-PEG (poly-L-lysine-g-polyethylene glycol) can be used as the carrier.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Obesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increased adiposity promotes pro‑inflammatory polarization of macrophages toward the M1 phenotype, in adipose tissue (AT), with subsequent increased production of pro‑inflammatory cytokines and adipokines, inducing therefore an overall, systemic, low‑grade inflammation, which contributes to metabolic syndrome (MetS), insulin resistance (IR) and T2DM. Targeting inflammatory mediators could be alternative therapies to treat obesity, but their safety and efficacy remains to be studied further and confirmed in future clinical trials. The present review highlights the molecular and pathophysiological mechanisms by which the chronic low‑grade inflammation in AT and the production of reactive oxygen species lead to MetS, IR and T2DM. In addition, focus is given on the role of anti‑inflammatory agents, in the resolution of chronic inflammation, through the blockade of chemotactic factors, such as monocytes chemotractant protein‑1, and/or the blockade of pro‑inflammatory mediators, such as IL‑1β, TNF‑α, visfatin, and plasminogen activator inhibitor‑1, and/or the increased synthesis of adipokines, such as adiponectin and apelin, in obesity‑associated metabolic dysfunction.
Patient will receive the enteral nutrition product Jevity 1.5 starting at 20mL per hour and increasing by 20mL every four hours until a goal rate delivering 12-14 kcals/kg is achieved. If feeding is interrupted, flow rate will be adjusted to compensate for nutritional loss.
Gynecological cancer patients in a chemotherapy unit in Trabzon were recruited in the study. Inclusion criteria for the study were volunteering to take part in the study, being able to read and write in Turkish, being 18 years of age or older, having been diagnosed with gynecological cancer, knowing that s/he had been diagnosed with cancer, having received at least one chemotherapy treatment and having cancer stage 2 or 3. Exclusion criteria in the study were having a verbal communication disability, having been diagnosed with psychotic and neurological disorders, having received, or receiving psychotherapy, living outside the city center of Trabzon, and receiving treatment at intervals longer than 21 days. The experimental group received 7 sessions of logotherapy interviews.
BACKGROUND: Hemorrhage is the leading cause of preventable death after trauma. In high-income countries first responders are trained in hemorrhage control techniques but this is not the case for developing countries like Guatemala. We present a low-cost training model for tourniquet application using a combination of virtual and physical components.
METHODS: The training program includes a mobile application with didactic materials, videos and a gamified virtual reality environment for learning. Additionally, a physical training model of a bleeding lower extremity is developed allowing learners to practice tourniquet application using inexpensive and accessible materials. Validation of the simulator occurred through content and construct validation. Content validation involved subjective assessments by novices and experts, construct validation compared pre-training novices with experts. Training validation compared pre and post training novices for improvement.
RESULTS: Our findings indicate that users found the simulator useful, realistic, and satisfactory. We found significant differences in tourniquet application skills between pre-training novices and experts. When comparing pre- and post-training novices, we found a significantly lower bleeding control time between the groups.
CONCLUSION: This study suggests that this training approach can enhance access to life-saving skills for prehospital personnel. The inclusion of self-assessment components enables self-regulated learning and reduces the need for continuous instructor presence. Future improvements involve refining the tourniquet model, validating it with first-responder end users, and expanding the training program to include other skills.
Glioblastoma, the most common malignant brain tumor in adults, is associated with a median overall survival duration of less than 2 years. Extraneural metastases occur in less than 1% of all patients with glioblastoma. The mechanism of extraneural metastasis is unclear. We present a case of extensive extraneural, extraosseous, epidural, and soft-tissue metastasis of glioblastoma. The diagnosis of metastatic glioblastoma was made only after next-generation sequencing (NGS) of the metastatic paraspinal lesions was completed. The CDK4, pTERT, PTEN, and TP53 molecular alterations seen in the initial intracranial glioblastoma were found in the paraspinal tumor, along with the addition of MYC, which is implicated in angiogenesis and epidermal-to-mesenchymal transition. Immunohistochemical stains showed that neoplastic cells were negative for GFAP. In conclusion, this case raises awareness about the role of NGS in the diagnosis of extraneural glioblastoma. This diagnosis was not possible with histology alone and only became evident after molecular profiling of the metastatic lesions and its comparison to the original tumor.
Regimen 2 arnica tincture applied 3 times a day for 45 days (group 2). For both regimens, the participant applies the tincture in the morning, afternoon and evening, that is, three times a day.
A sperm-producing decoction is disclosed and warms and invigorates kidney yang. The decoction is used for patients with male infertility caused by insufficiency of the kidney yang, low sperm count, azoospermia, or a sperm amount lower than a normal value, and low sperm motility. A traditional Chinese medicine composition is prepared from following raw material medicines by weight: prepared rehmannia root, Chinese wolfberry, raspberry, common dodder, pulp of dogwood fruit, fruit of magnoliavine, semen plantaginis, epimeddium and morinda root. The sperm-producing decoction has good effects for azoospermatism, oligospermia, and normal sperm count type infertility, and is good in effects and quick-acting in curative effects for male infertility. Natural traditional Chinese components are free of side effects for human bodies. The sperm-producing decoction has functions of strengthening sperms and effectively increasing the amount of sperms.
PURPOSE: The New England VA Hernia Registry was created in 2011 to prospectively collect relevant details of ventral hernia repairs, with the intention to assess and improve long term outcomes. The goal of this study is to assess registry compliance.
METHODS: All ventral hernia operations performed in five VA hospitals between 2011-2022 were obtained. We assessed compliance at the hospital and surgeon level.
RESULTS: 3,516 cases were performed. Overall compliance with registry entry was 37.5%, ranging from 10.8% to 67.2% across hospitals. At the hospital level, there was a negative correlation between average yearly hernia volume per surgeon and registry compliance (r2 = 0.53). Surgeon compliance varied within hospitals and over time.
CONCLUSION: Registry compliance was low and highly variable. Lack of interest, incentives, oversight, and surgeon turnover are possible factors for noncompliance. Building a registry with these factors in mind, providing timely feedback, and conducting frequent audits may improve compliance.
BACKGROUND: Secondary patella resurfacing is often performed for dissatisfaction following primary knee arthroplasty where the native patella was retained. The purpose of this meta-analysis was to evaluate outcomes of secondary patella resurfacing.
METHODS: The systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies reporting on patients who underwent secondary patella resurfacing after previous primary knee arthroplasty with retention of the native patella were considered eligible. The risk of bias was assessed using the Methodological Index for Non-Randomized studies tool. A random-effects model and the inverse-variance weighting method was used for meta-analysis. There were sixteen retrospective studies including 604 knees (594 patients) with a mean follow up of 42 months (range, 2 to 197).
RESULTS: An overall improvement in patient-reported outcomes (PROMs) was achieved in 53% of cases from pooled data available for 293 knees [95% Confidence Interval (CI) (0.44, 0.62), I2=68% - moderate heterogeneity]. The pooled proportion of patients satisfied with the procedure was 59% [95% CI (48, 68), I2 = 70% - moderate heterogeneity] in a sample size of 415. There was a minimal rate (2%) of complication incidence when performing secondary patella resurfacing and a pooled rate of revision surgery of 10%.
CONCLUSIONS: An improvement in pain, satisfaction, and PROMs was achieved in slightly more than half of the patients following secondary patella resurfacing. However, studies lacked standardized objective selection criteria for the procedure and the available data was predominantly retrospective, with high heterogeneity and variation in outcome reporting.
Six doses remlarsen (5.3 mg) over a period of 2 weeks at the site of one excisional skin wound and six doses Placebo over the same period at the site of a second excisional skin wound. Each subject will serve as their own simultaneous control.
PURPOSE OF REVIEW: Poor diet and food insecurity contribute to the dramatic rise in diet-related chronic disease and increasing cost of healthcare. The Food as Medicine (FAM) framework describes food-based interventions designed to prevent, manage, and treat diet-related diseases. However, FAM interventions have not been widely implemented or evaluated in pediatric populations, so critical questions remain about their optimal delivery and design, efficacy, and funding opportunities. We have reviewed the recent literature and offer insights into potential funding and implementation strategies for pediatric healthcare providers.
RECENT FINDINGS: Data from adult and population-level interventions provide evidence that FAM interventions positively impact diet quality, food security, health outcomes, and healthcare utilization and cost in adults and households with children. Evidence from recent pediatric-based FAM interventions and population data from recent changes to federal nutrition programs support the use of food-based interventions to improve child diet quality, food insecurity, and potentially impact long-term health and healthcare utilization and cost.
SUMMARY: Applying the entire spectrum of evidence-based FAM interventions in pediatric settings from prenatal to adolescent stages will offer the greatest opportunity to ensure all children have access to enough healthful food so they can achieve their highest potential in life.
The present invention includes a method to collate, organize, display, and interact with past, present, and future health data related to a patient. When the health data is related to anatomy, the health data is automatically visualized with relevant locations, images, diagrams, and maps along with interactive anatomic points or distributions containing context-aware information related to the anatomy, specialty, diagnosis, procedure, language, or other data. The present invention uses healthcare data in digital shadow charts, or paper shadow charts, or both, to create a comprehensive record and to seamlessly blend paper and electronic documentation. The charts automatically collate past, current, and future healthcare data that are automatically linked.to anatomic maps and healthcare data for visualization, modification, augmentation, and automation of healthcare record generation, and retrieval. Shadow charts collate and display information from dynamic anatomic addresses, data blocks, and metadata blocks on an anatomic map translated to user language, with recreated anatomic sites and health data. Automated workflows such as prescription refills, suggested diagnostic tests, flag areas of concern for follow up, etc. are included on the shadow chart.
BACKGROUND: Although excessive opioid use is a significant global health issue, there is a lack of literature on the prescribing patterns for postoperative opioid use and exposure after discharge among surgical patients. This study aimed to examine the rate and predictors of opioid dispensing and high opioid exposure after hospital discharge from surgery in New Zealand (NZ) between January 2007 to December 2019.
METHODS: This is a retrospective population-based cohort study inclusive of all ages and surgical specialties. Data were obtained from the NZ Ministry of Health's national health databases.
RESULTS: 1 781 059 patients were included in the study and 20.9% (n = 371 882) of surgical patients received opioids within 7 days after hospital discharge. From those who were dispensed with opioids after hospital discharge, 36.6% (n = 134 646) had high opioid exposure. Orthopaedic surgery (AOR 6.97; 95% CI 6.82-7.13) and history of opioid use (AOR 3.18; 95% CI 2.86-3.53) increased the odds of postoperative opioid dispensing and high opioid exposure respectively. Severe multi-morbidity burden (AOR 0.76; 95% CI 0.73-0.78) and alcohol misuse (AOR 0.84; 95% CI 0.77-0.93) lowered the odds of postoperative opioid dispensing and high opioid exposure respectively.
CONCLUSIONS: Our findings suggest a concerning rate of high opioid exposure among surgical patients after discharge. The predictors for postoperative opioid dispensing and high opioid exposure identified in our study provide insight into opioid prescribing patterns in NZ and inform future postoperative pain management.