anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients who are admitted to the hospitalist service at the University of Michigan Hospital will be screened for the presence of severe sepsis. Those who are deemed eligible and provide consent will be enrolled. Study patients will receive additional physical therapy according to a protocol developed for this study in addition to the usual care recommended by their regular treating physician. Additional treatments will be individualized based on enrolled patients' baseline physical function and progress and may include standing, stretching, transferring, and walking - either with assistance or independently. Treating therapists have been trained in the use of the protocol and individualization to maintain the highest standard of patient safety. Patients will be contacted 30 days after discharge to answer questions about their health and ability to perform routine tasks at home.
Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isosorbide Dinitrate tablet contains 5 mg or 40 mg of isosorbide dinitrate. The inactive ingredients in 5 mg tablet are magnesium stearate, lactose monohydrate, microcrystalline cellulose and FD&C red 40. The inactive ingredients in 40 mg tablet are magnesium stearate, microcrystalline cellulose, FD&C yellow 6, D&C yellow 10, and FD&C blue.
Serious concerns have been raised over the safety of vaginal mesh tapes for stress urinary incontinence (SUI). Autologous rectus fascial sling and the more recent 'sling on a string' through a laparotomy are gaining popularity as native tissue options for SUI. We describe a novel technique of laparoscopic mid-urethral autologous rectus fascial sling for SUI. Ten patients underwent this new technique safely. At 12 months, all patients reported cure of SUI with normal voiding. The advantages of this technique include the minimal access approach, introduction of the sutures under laparoscopic guidance, and avoidance of over-tightening of the sling.
We will select a purposive sample of postpartum women into two groups: those who receive inpatient HPV vaccine and those who decline the inpatient dose to interview until we reach thematic saturation which we anticipate to occur with about 8-10 individuals per group. Patients will be selected to include diverse representation in age, race, ethnicity, and parity.
BACKGROUND: The safety and the clinical success of simultaneous bilateral total knee arthroplasty (BTKA) is controversial. The aim of this study was to compare complications and patient-reported outcomes following simultaneous BTKA (simBTKA) versus staged BKTA (staBTKA) in patients affected by bilateral symptomatic end-stage knee osteoarthritis (OA).
METHODS: Data from patients who underwent simBTKA or staBTKA at a single institution from January 2017 to December 2020, with a minimum 1-year follow up period were retrospectively collected. Differences in terms of complications and clinical success were compared among the simBTKA and staBTKA patient groups. Alpha was set at 0.05.
RESULTS: A total of 173 patients were included in this study. The results revealed no statistically significant differences between the two groups in terms of mortality, revision rate, readmission rate, local and systemic complications and patient-reported outcomes. SimBTKA group had a shorter operating room time (96 (73-119) vs. 195 (159-227); P < 0.0001), and length of hospital stay (4 (3-5) vs. 7 (6-9); P < 0.0001) compared with the staBTKA group.
CONCLUSIONS: SimBTKA performed in a selected patient population at a high-volume center can be considered comparable to staBTKA in terms of safety, postoperative complications, 30-day readmissions and patient satisfaction. Consequently, reduced operating room time and hospital stay renders simBTKA a cost-effective and advantageous option, not only for patients, but also for healthcare institutes. Furthermore, the current study also highlights the importance of correct patient selection based on clinical preoperative characteristics.
All patients given 8 mg estradiol valerate orally on daily basis for 13 days beginning with the first day of either a spontaneously or induced menstrual cycle. Patients examined using transvaginal ultrasonography on day 13 of exogenous estrogen supplementation to measure endometrial thickness and to detect signs of escape ovulation. In all Patients progesterone supplements in form of two vaginal prontogest suppositories 400 mg each. Transfer of frozen embryo will be done on day 5 after progesterone supplementation.
Subjects will participate in structured physical therapy consisting of 3 months of eccentric strength training. This twelve-week program will consist of 4 PT sessions at week 0, week 4, week 8, and week 12.
PURPOSE:To provide a tape preparation having improved absorbability in living body, and composed of a substrate and a plaster layer applied to said substrate and obtained by adding a specific transcutaneous absorbefacient to a plaster layer containing a transcutaneous absorptive drug. CONSTITUTION:An transcutaneous absorbefacient consisting of an N-acylated amino acid (preferably having a 8-18C acyl group such as glycine, etc.) or an N-acylated oligopeptide (preferably having a molecular weight of <=1,000 such as N-lauroylprolyl-prolylglycine, etc.) is added to a plaster layer containing a transcutaneous absorptive drug, and the plaster layer is applied to a substrate to obtain the objective tape preparation. The transcutaneous absorbefacient promotes the loosening of corneal layer and contributes to the improvement of the transcutaneous absorptivity of a drug. The drug used in the above preparation is e.g. corticosteroids such as hydrocortisone, analgesic and anti- inflammatory agents such as acetoaminophen, etc., and hypnotic sedatives such as phenobarbital, etc.
The incidence of peripheral nerve injury (PNI) in China is continuously increasing. With an inability to function due to sensory and motor abnormalities, patients with PNI suffer from neuropathic pain and subsequent lesions. Presently, effective treatments for PNI are limited. To determine the role of neuroprotectin D1 (NPD1) in PNI, a sciatic nerve crush injury model was developed to investigate the impact of NPD1 on sensory and motor function recovery following nerve injury. The results demonstrated that NPD1 administered at different time points might reduce mechanical allodynia and thermal hyperalgesia caused by PNI, and its analgesic effect was not tolerated. Immunohistochemistry analyses revealed that administering NPD1 to PNI mice decreased the spinal microglia and astrocyte activation and decreased the inflammatory factor expression in the spinal dorsal horn. Furthermore, NPD1 can inhibit the invasion of IBA-1+ macrophages in dorsal root ganglions generated by nerve injury. Meanwhile, it can help rehabilitate motor and neuromuscular functions following PNI. The results indicate that NPD1 may be involved in the sensory and motor function recovery following PNI.
The invention discloses application of a medicament for increasing the transport of ventral hippocampus to medial prefrontal cortical iron in preparing a medicament for treating neuropsychiatric diseases. The inventors overexpressed human iron transporters within neurons in the ventral hippocampus projected to the medial prefrontal cortex. As a result, it was found that iron concentration in the medial prefrontal cortex was significantly increased 14 days after overexpression of the virus, demonstrating that this method can increase iron transport in the ventral hippocampus → medial prefrontal cortex. Over-expressing mice had increased total motor course, increased time in the middle of the open field, decreased time in the black box, increased time to overhead arm opening, and anxiolytic-like behavior compared to control mice. After successful modeling, mice with increased iron transport after deferiprone injection had increased overhead open arm time, increased open arm entry times, and anxiolytic-like behavior compared to normal controls. In conclusion, increasing iron transport in the ventral hippocampus → medial prefrontal cortex has prophylactic and therapeutic effects on anxiety.
PURPOSE:The titled table to disintegrate in water, etc., in a short time, blended with a zeolite retaining a gas by adsorption as a disintegrator. CONSTITUTION:A tablet blended with a zeolite retaining one or more gases selected from carbonic acid gas, oxygen, nitrogen, helium, neon, argon and hydrogen by adsorption as a disintegrator. Tablets are required to have rapidly dissolving properties, slow-dissolving properties depending upon uses. When they are added to and dissolved in a solvent such as water, etc., to prepare a solution of an active ingredient when they are used, preferably they are dissolved as rapidly as possible. When the zeolite is used as the integrator, since the tablet is disintegrated extremely in a short time and an active ingredient is released when it is added to a solvent, a solution, suspension or dispersion of the active ingredient can be rapidly prepared in use. A zeolite having 5-60wt% based on the whole composition of a synthetic zeolite shown by the formula (M is metal with valence n; x is 0.7-1.5; y is 0.8-10; z is >=0) is used as the zeolite.
Participants in this arm followed a traditional paper-based exercise program for 6 weeks. The program included written instructions and images illustrating the exercises. This arm served as a comparison to evaluate the effectiveness of the traditional exercise delivery method against the digital platform.
The World Health Organization estimates that the three most prevalent neurologic disorders worldwide are tension-type headache (1.5 billion), migraine (958.8 million), and medication overuse headache (58.5 million). Collectively, these three disorders contribute approximately 17% to the global burden of neurologic diseases, with migraine the second most disabling disease overall. TTH (Tension Type of Headache) is defined as mild to moderate band-like pressure headache with few associated symptoms. It varies considerably in frequency and duration, from rare, short-lasting episodes of discomfort to frequent, long-lasting, or even continuous disabling headaches.Physiotherapy treatment based on manual therapy achieved positive outcomes in pain intensity and frequency, disability, impact of headache, quality of life, and craniocervical range of motion in adults with TTH. Although pervious findings showed a clinical improvement, there is no clear evidence that one technique is superior to another.Neurodynamic techniques can improve mechanical functions in nerve structures, such as tension and sliding functions. When the nerve structure experiences clamping and disrupts mobility, pain occurs along the nerve. Neurodynamic sliding techniques play a major role in improving blood circulation and axonal transport, as well as increasing nerve integrity and reducing the pressure caused by intraneural and extraneural fibrosis. thirty patients with tension headache will be allocated randomly into two equal groups. the first one will receive craniocervical mobilization and a selected physiotherapy program and the control group will receive selected physiotherapy program for one month.
Dosage Form: Oral dietary supplement. Dosage: Blend containing Procyanidin C1, Pterostilbene, and Spermidine. Frequency: Administered once daily. Duration: 12 weeks.
Oral contraceptives have been shown to cause glucose intolerance in a significant percentage of users. Oral contraceptives containing greater than 75 micrograms of estrogens cause hyperinsulinism, while lower doses of estrogen cause less glucose intolerance. Progestogens increase insulin secretion and create insulin resistance, this effect varying with different progestational agents. However, in the nondiabetic woman, oral contraceptives appear to have no effect on fasting blood glucose. Because of these demonstrated effects, prediabetic and diabetic women should be carefully observed while taking oral contraceptives.

A small proportion of women will have persistent hypertriglyceridemia while on the pill. As discussed earlier (see WARNINGS, 1a and 1d), changes in serum triglycerides and lipoprotein levels have been reported in oral contraceptive users.
An imaging instrument includes a compact hand-held housing having an electronic imaging element supported within a housing, and a plurality of interchangeable instrument heads separably attachable to the housing. Each of the instrument heads includes an optical system disposed in alignment with the electronic imaging element along an instrument viewing axis. Preferably, the instrument further includes an integral display for displaying at least one captured or real-time video image as viewed through the instrument head of choice. The instrument includes a controller with sufficient programmable logic to capture and store a plurality of imaging images which can be transferred along with audio and/or annotation data relating to a captured image. Corresponding video and audio data can be then transferred using a receiving cradle to a computer which contains software which organizes the stored data for further processing. In a preferred example, the audio files can be transcribed through a network utilizing voice recognition software.
BACKGROUND: Occurrence of squamous cell carcinoma (SCC) even in early-stage, untreated chronic lymphocytic leukemia (CLL) patients can be a significant morbidity issue with occasional transformation into metastatic skin lesions.
METHODS: CLL cells and extracellular vesicles (EVs) from CLL patients' blood/plasma were purified and used. Expression/activation of AXL and its functions in normal keratinocytes (HEKa) were assessed in vitro co-culture system and in SCC tissues.
RESULTS: We detected aberrant activation of AXL, AKT and ERK-1/2 in SCC cell lines compared to HEKa. We also detected increased expression of AXL in primary SCC tissues obtained from CLL patients. Increased activation of AXL, AKT, ERK-1/2 and Src was discernible in HEKa upon co-culturing with CLL cells. Further analysis suggests that Gas6, a ligand of AXL, regulates AXL activation in co-cultured HEKa. Interestingly, exposure of HEKa cells to CLL plasma-derived EVs induced expression of AXL, P-AKT, and EMT-associated markers leading to migration of the cells. Finally, pharmacologic inhibition of AXL induced cell death in SCC lines in a dose dependent manner.
CONCLUSIONS: Our findings that CLL cells likely are involved in driving SCC progression, at least in part, via activation of the AXL signaling axis, indicating that AXL inhibition may be beneficial for our CLL patients with SCC.
Liu et al. (2003) have reported that DM protected dopamine (DA) neurons against inflammation-mediated degeneration. Zhang et al.'s (2004) novel finding was that 1-10 μM DM protected DA neurons against LPS (10 ng/mL)-induced reduction of DA uptake functionally in rat primary mixed mesencephalic neuron-glia cultures. Morphologically, in lipopolysaccharide (LPS)-treated cultures, in addition to the reduction of abundance of DA neurons, the dendrites of the remaining DA neurons were significantly less elaborate than those of controls. In cultures pretreated with DM (10 μM) before LPS stimulation, DA neurons were significantly more numerous and the dendrites less affected. Significant neuroprotective was observed in cultures with DM added up to 60 minutes after the addition of LPS. Thus, DM significantly protects DA neurons not only with pretreatment but also with post-treatment (Zhang et al. 2004). The mechanism of the neuronprotective effect of DM is associated with the inhibition of microglia activation but not with its NMDA receptor antagonist property. Zhang et al. (2005) have examined several N-methyl-D-aspartate (NMDA) receptor antagonists, including MK801, AP5, and memantine. Results from these studies indicate that among these compounds tested there was no correlation between the affinity of NMDA receptor antagonist activity and potency of the neuroprotective on DA neurons. On the contrary, a better correlation was found between the anti-inflammatory potency and the neuron protection. These results suggest that the DA neuroprotection provided by DM in the inflammation-related neurodegenerative models is not mediated through the NMDA receptor. This conclusion is not in conflict with the previous reports, indicating that NMDA receptor blockade is associated with the neuroprotective effect of DM in acute glutamate-induced excitotoxicity models. The above evidences of benefit on auto-immune system with dextromethorphan would support that dextromethorphan as add-on therapy to atypical antipsychotics might be more effective than atypical antipsychotics alone on improvement of both positive and negative symptoms in schizophrenia.
This is a prospective, randomized, open-label trial. Eligible ESRD patients who are on thrice weekly HD schedule will be screened from retrospective review of clinical and laboratory parameters from our clinical practice group. A total of 40 study participants (randomized 1:1 study drug: usual care) will be enrolled. Duration of study medication exposure will be 4 weeks. The total duration of study, from enrollment until the end of the washout period will be 7 weeks.

This is a proof of concept study, to determine whether administration of patiromer has the potential to change the risk category for ESRD patients who are on conventional HD schedules. In addition, the study will develop and pilot study procedures that could be implemented in a large-scale clinical trial. By nature of the limited size of the study, the power of the trial will be limited. Reducing serum potassium with the use of low dialysate potassium is actually associated with an increased risk of sudden cardiac death. Furthermore, HD patients already carry a high pill burden, and it is unclear if prescription of an additional oral medication will reduce the frequency of episodic hyperkalemia.
PURPOSE: A bathing composition for treating and alleviating atopy is provided to enable penetration into dermis as well as epidermis without side effects, to remove toxicity, and to treat and alleviate atopic dermatitis. CONSTITUTION: A bathing composition for treating and alleviating atopy contains extracts of Angelica gigas Nakai, Astragalus membranaceus BUNGE, Dioscorea batatas, Taraxacum platycarpum, and Eriobotrya japonica Lindl. as active ingredients. The bathing composition contains 1-20 wt% of Angelica gigas Nakai, 1-20 wt% of Astragalus membranaceus BUNGE, 1-20 wt% of Dioscorea batatas, 10-40 wt% of Taraxacum platycarpum, and 10-40 wt% of Eriobotrya japonica Lindl. The bathing composition additionally contains one or more additives selected from among herbs, perfumes, pyroligneous liquor, charcoal, and dyes. A method for manufacturing the bathing composition comprises the steps of: extracting Angelica gigas Nakai, Astragalus membranaceus BUNGE, Dioscorea batatas, Taraxacum platycarpum, and Eriobotrya japonica Lindl. with hot water; and drying the hot water extract. [Reference numerals] (AA) Normal (normal group); (BB) PI-control (control group); (CC) PI-composition (100ug/ml); (DD) PI-composition (200ug/ml)
The invention is used in neurosurgery and tissue engineering of organs to replace defects of nervous tissue of a mammal brain and spinal cord in reconstructive neurosurgical operations. The object of invention is to develop a tissue-replaceable artificial cell-biopolymer neuroendoprosthetic system (ACBP NEPS) for surgical plasty of defects of nervous tissue of brain and spinal cord that will stimulate regeneration and growth of damaged axons of neural cells, as well as to develop a production method of the ACBP NEPS and a method of reconstructive neurosurgical operation using the ACBP NEPS. The ACBP NEPS is an elastic cell-biopolymer biologically active mass produced from a heterogeneous collagen-containing matrix for implantation and a biocomposition of cell preparations of various types of autologous cells of a patient. The biocomposition comprises, in a NaCl solution, neural stem cells (NSC), neuroglial ensheathing cells (NGEC), endothelial cells with CD34+ marker (EC) and purified mononuclears (MN) in the following ratios (in parts according to numbers of the cells): 0.8 to 1.2 of NSC; 1.6 to 2.4 of NGEC; 4 to 6 of EC; 4000 to 6000 of MN. The method of production of the ACBP NEPS comprises perfusion of the biocomposition of the cell preparations of various types of autologous cells of a patient into the heterogeneous collagen-containing matrix for implantation to obtain the elastic cell-biopolymer biologically active mass. The method of the reconstructive neurosurgical operation to replace the defects of a mammal brain and/or spinal cord and/or vegetative nervous system comprises implantation of the ACBP NEPS into the defect of neural tissue.
Acute respiratory infections, malaria, and sepsis remain leading causes of death in children throughout the world.These conditions may lead to respiratory distress and eventually failure if not adequately managed. In developing countries with limited resources, advanced airway management and support can be challenging and needs to be approached in a different manner than is done in developed nations. For example, the use of invasive mechanical ventilation for respiratory distress is not an option in many resource-limited countries due to the lack of available technology, infrastructure, and trained personnel. Other alternatives should be utilized in order to support children with reversible conditions during their acute respiratory distress stage. One such alternative is non-invasive positive pressure.

Prior research demonstrated that nasal bubble CPAP can be successfully introduced and utilized in a developing country's emergency ward. Nurses in four Ghanaian district hospital emergency wards (Kintampo, Mampong,Nkoranza, and Wenchi) were able to safely apply CPAP and monitor the patient's response. The investigators demonstrated that patients receiving CPAP had a significant decrease in respiratory rate compared with those that did not with a mean difference of 14 breaths per minute. There were no major side effects associated with the use of CPAP. Now that CPAP has demonstrated to decrease respiratory rate in a non-specific disease population presenting with respiratory distress it is important to determine if it also improves survival. Therefore, the purpose of the study is to determine if the use of CPAP in children 1 month to 5 years of age with respiratory distress decreases mortality.
Participants who initially received ipilimumab, 0.3 mg/kg, in a parent study received ipilimumab, 10 mg/kg in the current study. Ipilimumab was administered as an individual open-label dose every 3 weeks for the first 10 weeks of reinduction for a total of 4 separate doses unless the patient experienced disease progression or withdrew consent. Participants had to wait 3 weeks from the last dose of ipilimumab in a parent study to the first dose of ipilimumab in the current study.
Group A Group A will receive hot packs along with all hip muscle strengthening exercises. All exercises were performed for 3 sessions per week for 6 weeks. Outcome measures will be taken at baseline, in 3rd week, and at the end of the 6th week.