anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism. We here provide the mechanistic evidence in support of the relevance for these observations. Angiopoetin-1 (Ang-1), which promotes vascular integrity, was decreased in blood plasma of human and murine septic newborns. In preclinical models, administration of Ang-1 provided prophylactic protection from septic death. Arachidonic acid metabolism appears to be functionally connected to Ang-1 via reactive oxygen species (ROS) with a direct role of nitric oxide (NO). Strengthening this intersection via oral administration of arachidonic acid and/or the NO donor L-arginine provided prophylactic as well as therapeutic protection from septic death while also increasing plasma Ang-1 levels among septic newborns. Our data highlight that targeting angiogenesis-associated pathways with interventions that increase Ang-1 activity directly or indirectly through ROS/eNOS provide promising avenues to prevent and/or treat severe neonatal sepsis.
PURPOSE:The titled remedy, containing threo-3,4-dihydroxyphenylserine and a decarboxylase inhibitor as principal components, and particularly effective for the crouching symptom (freezing phenomenon) of Parkinson's disease (parkinsonism). CONSTITUTION:A remedy for Parkinson's disease (parkinsonism) containing the DL- or L-isomer of threo-3,4-dihydroxyphenylserine (hereinafter referred to as thereo-DOPS) and a decarboxylase inhibitor (hereinafter referred to as DCI), e.g. carbidopa or benserazide, as principal components. The crouching phenomenon (freezing phenomenon) of old Parkinson's disease is considered to be releated to the reduction in the content of norepinephrine (hereinafter referred to as NE) in the brain and activity of dopamine-beta-hydroxylase (hereinafter referred to as DBH) which is a biosynthetic enzyme for converting the dopamine into NE. The threo-DOPS is converted into the NE by the decarboxylase, and the DCI acting peripherally in the remedy inhibits the decarbonylation process of the L-threo-DOPS in the periphery. The administered threo-DOPS is transferred to the central nervous system effectively to increase the NE concentration in the central nervous system.
Day 0: Post-announcement interview with allied health professionals (information and support interview) and then between Day 7 and Day 14, phone call (support relationship, answers to questions), followed by a hotline dedicated to questions. Between month 3 and month 10: patient focus group.
Minimally invasive pancreaticoduodenectomy (MIPD) has been routinely performed in major centers, and its feasibility and efficacy in tumor treatment have been highly recognized. Malnutrition has been associated with higher rates of morbidity, and increased mortality in surgical patients. The effect of the nutritional status on MIPD outcomes still remains unclear and controversial. The clinical data of 207 consecutive patients who had MIPD between June 2017 and December 2022 were retrospectively analyzed. A multidimensional nutrition assessment was performed before surgery. Multivariable analysis and propensity score matching (PSM) was performed to identify the association of preoperative nutritional status on postoperative short-term prognosis(Morbidity-Mortality, Clavien-Dindo classification ≥ IIIa, postoperative pancreatic fistulas and biliary fistula). In the multivariable analysis, sarcopenia (OR 9.74, 95% CI 3.34-43.03) was associated with postoperative morbidity and sarcopenia (OR 6.74, 95% CI 2.24-30.24) was associated with major complications. In the cohort after PSM, sarcopenia remained independently associated with morbidity (OR 12.44, 95% CI 3.72- 59.16) and major complications (OR 8.14, 95% CI 2.13- 43.83). Sarcopenia before MIPD has an impact on postoperative outcomes. Nutritional status assessment, especially sarcopenia, should be part of the routine preoperative procedures to provide early and appropriate nutritional support for MIPD patients.
PROBLEM TO BE SOLVED: To provide an influenza vaccine formulation for immunizing against influenza disease.SOLUTION: Provided is an influenza virus or antigenic preparation thereof in the manufacture of an immunogenic composition for a two-dose primary vaccination of a human individual or population against influenza, wherein the composition is prepared for administration of the two primary doses at an interval of less than 14 days. The composition for priming is adjuvanted. The adjuvant is a metabolic oil, an emulsifying agent, and an oil-in-water emulsion that comprises sterol and/or tocol optionally. Tocol is tocopherol, such as α-tocopherol. The metabolic oil is a squalene, existing in an amount of about 0.125% (v/v) to about 5% (v/v) of the total amount of an immunogenic composition. The emulsifying agent is polysorbate 80 or Tween 80, existing in an amount of about 0.1% (v/v) to about 2.0% (v/v) of the total amount of an immunogenic composition.
Chronic graft-versus-host disease (cGVHD) is a potentially life-threatening complication after allogeneic hematopoietic stem cell transplantation. Standard steroid first-line treatment could not satisfy therapeutic needs due to limited efficacy. As a highly selective Janus kinase (JAK) 1 inhibitor, SHR0302 exhibits a reduced inhibition effect on JAK2 and might have less effect on hematopoiesis. This phase I clinical trial investigated the tolerability and safety of SHR0302 in combination with prednisone, and its early efficacy evidence as a potential first-line treatment to moderate/severe cGVHD. The standard 3 + 3 dose escalation was implemented to find the optimal dose of SHR0302. And prednisone was concurrently administrated with a dose of 1 mg/kg/d and then gradually tapered after 2 weeks. Eighteen patients were enrolled into the study. Grade ≥ 3 treatment-related adverse events were observed in 38.9% of patients. Only one patient developed DLT (grade ≥ 3 hypercholesterolemia) in the highest dose-level group who had pre-existing hypercholesterolemia. The maximum tolerated dose was not reached. No patient discontinued treatment due to AEs. Sixteen out of 18 patients were evaluable for responses, the ORR at week 4 and week 24 were 94.4 and 87.5%, respectively. Overall, the treatment of SHR0302 combined with prednisone was safe and well-tolerated, preliminary clinical results presented a high response for previously untreated cGVHD and a significant reduction in prednisone use in this study. A phase II trial will be conducted to further investigate its therapeutic effects clinically.
PURPOSE OF REVIEW: The aim of this study is to provide an update on mitral valve prolapse (MVP) and mitral annular disjunction (MAD) and who may be at risk for ventricular arrhythmias and sudden cardiac death.
RECENT FINDINGS: MVP is generally considered a benign condition. However, a small subset of patients may be at risk for life-threatening ventricular arrhythmias. Among the risk factors identified in adults include patients with bileaflet mitral valves, myxomatous changes, myocardial fibrosis, and the presence of MAD. Advances in multimodal imaging have allowed for improved identification of fibrosis, anatomical valve derangements, and the amount of MAD. Recent guidelines have suggested that patients with MVP with or without MAD may be at risk for life-threatening arrhythmias if they have had prior ventricular arrhythmias, ventricular dysfunction, or unexplained syncope. Yet, extrapolation of adult data to a pediatric cohort with similar MVP and MAD at this juncture is challenging. There is, however, early evidence that some pediatric patients with significant myocardial fibrosis or abnormal tissue Doppler may be at risk for ventricular tachycardia.
SUMMARY: Mitral valve prolapse and mitral annular disjunction at times coexist and at other times can be seen as isolated entities. While the incidence of arrhythmic MVP is quite rare, there is increasing evidence that certain select adults with MVP may be at risk for ventricular tachycardia and sudden cardiac death. Future multicenter studies are needed to better understand the natural history of arrhythmic mitral valve disease and how early disease manifestation in children may impact findings now being reported in young adults.
FIELD: medicine, sexology. SUBSTANCE: invention relates to treatment of erectile dysfunction. Invention proposes to use 1,2,3,4-tetrahydropyrrolo-[1,2- a] -pyrazine hydrosuccinate for this purpose. Invention allows to enhance sexual activity, eliminate erectile dysfunction, elevate amount of effective conceptions being without damage of genetic structures of germ cells and without negative effect on behavioral responses and functions of body. EFFECT: valuable medicinal properties of substance. 2 tbl
Glyphosate-based herbicides (GBH) are the most widely used pesticides globally. Studies have indicated that they may increase the risk of various organic dysfunctions. Herein, we verified whether exposure to GBH during puberty increases the susceptibility of male and female mice to obesity when they are fed a high-fat diet (HFD) in adulthood. From the 4th-7th weeks of age, male and female C57Bl/6 mice received water (CTL group) or 50 mg GBH /kg body weight (BW; GBH group). From the 8th-21st weeks of age, the mice were fed a standard diet or a HFD. It was found that pubertal GBH exposure exacerbated BW gains and hyperphagia induced by HFD, but only in female GBH-HFD mice. These female mice also exhibited high accumulation of perigonadal and subcutaneous fat, as well as reduced lean body mass. Both male and female GBH-HFD displayed hypertrophic white adipocytes. However, only in females, pubertal GBH exposure aggravated HFD-induced fat accumulation in brown adipocytes. Furthermore, GBH increased plasma cortisol levels by 80% in GBH-HFD males, and 180% in GBH-HFD females. In conclusion, pubertal GBH exposure aggravated HFD-induced obesity, particularly in adult female mice. This study provides novel evidence that GBH misprograms lipid metabolism, accelerating the development of obesity when individuals are challenged by a second metabolic stressor, such as an obesogenic diet.
During the session each forearm of the subject will be divided into four squared areas (2.5x2.5 cm), see Figure 4. Four of the areas will be treated with doxepin for 1 hour and 30 minutes (with a patch to deposit 1.2 grams of cream). Each patch will be covered with Tegaderm I.V., an occlusive, adhesive dressing (3M), for at least 1½ hours 48. At the end of the pre-treatment period, the patches will be removed and the skin will be cleaned with alcohol.
Compositions and methods are provided for the modulation of abnormal expression of β-amyloid. oligonucleotides are provided which are specifically hybridizable with RNA or DNA encoding β-amyloid. Oligonucleotides specifically hybridizable with a translation initiation site, codon 717, codon 670 or codon 671 of RAPP are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating β-amyloid expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the mutant RAPP gene. Methods for diagnosis, detection and treatment of diseases associated with abnormal βAPP expression are also disclosed.
The invention relates to a process for preparing a Chinese thorowax tea. The process mainly comprises the following steps: (1) removing impurities of Chinese thorowax, and washing and drying the Chinese thorowax; (2) deactivating enzymes of the cleaned Chinese thorowax; (3) press-forming the Chinese thorowax subjected to enzyme deactivation; (4) drying the press-formed Chinese thorowax; (5) performing sterilization to obtain the Chinese thorowax tea. The Chinese thorowax tea is simple in formula and has no side effect, and the utilization rate of Chinese thorowax is increased. By adopting the method, volatile oil and total flavonoids in Chinese thorowax are retained to the maximal degree, and the tea has very good effects of preventing diseases and keeping healthy, namely Chinese thorowax can be used for improving the autoimmunity and enhancing disease preventing and resisting capability. In addition, Chinese thorowax also has strong painkilling and anti-inflammatory effects. The method is simple, is low in cost, and has important prospect of application.
Patients with severe coronary artery disease and chronic ischemic cardiomyopathy with a LVEF ≤40% who are scheduled for elective CABG according to accepted guidelines. Additional criteria include the following: age \<75 years, history of myocardial infarction (not less than 14 days before the procedure), LVEF ≤40 % assessed with echocardiography, and a distinct area of dyskinetic or akinetic left ventricular myocardium corresponding with the infarct localization.
INTRODUCTION: Direct current cardioversion (DCCV) remains one of the recommended management strategies for symptomatic atrial fibrillation (AF). Antiarrhythmic drugs (AAD) are prescribed post procedure to maintain sinus rhythm (SR). Limited literature exists on the AAD prescribing practices and their efficacy, post-DCCV in rural Australia.
OBJECTIVE: The primary aim was to determine the preferred AAD post-DCCV and the factors affecting AAD prescribing practices. The secondary aim was to assess the efficacy of the AAD in maintaining SR.
DESIGN: A retrospective observational audit of patients with non-valvular AF who underwent successful elective DCCV for symptomatic AF, during 2015-2020 at a regional hospital in New South Wales (NSW) (Dubbo Base Hospital). Patients were followed up for a duration of 12 months post-DCCV.
RESULTS: 233 patients underwent successful DCCV during the study duration. Amiodarone was the preferred AAD of choice post-DCCV followed by sotalol and flecainide, respectively (36.5% vs. 27.8% vs. 1.3%). 35.2% patients were not prescribed AAD. Amiodarone and sotalol had similar but modest efficacies and neither were superior to no AAD, in maintaining SR 12 months post-DCCV (AF recurrence rate 61.5% vs. 68.2% vs. 71.6% respectively, p = 0.37). Antecedent cerebrovascular accident (CVA), pulmonary disease, smoking, prior treatment with digoxin, diuretics and left ventricular (LV) dysfunction were factors that influenced AAD prescribing practices.
CONCLUSION: The study demonstrates equal efficacies of amiodarone, sotalol and no AAD in maintaining SR 12 months post-DCCV. Prescribing practices post-DCCV at Dubbo Base Hospital differ from observed national trends and guidelines. AAD prescription requires a multifaceted approach with a key consideration to prioritise safety over efficacy, being mindful of challenges in delivering optimal healthcare in a rural setting.
The invention discloses a traditional Chinese medicine pill for nourishing yin, clearing heat and lubricating intestines, which is prepared from the following components in part by weight: the invention relates to a traditional Chinese medicine composition for treating constipation, which is prepared from 10 traditional Chinese medicines of dried rehmannia root, figwort root, dwarf lilyturf tuber, tatarian aster root, Chinese angelica, raw largehead atractylodes rhizome, fructus cannabis, immature bitter orange, coffee senna, snakegourd fruit and the like. 1. Has no influence or little influence on normal physiological functions and no toxic or side effect. 2. The effect is nonspecific and broad-spectrum. 3. Has effects in regulating normal physiological function of intestine, nourishing yin, tonifying blood, clearing away heat, promoting fluid production, loosening bowel to relieve constipation, clearing intestine, purging heat, regulating functions of intestine, promoting fluid production, and loosening bowel to relieve constipation. 4. Can improve the clinical symptoms and signs of patients and has good effect of radically treating constipation.
All usual care provided pre and post-operative management will continue, uninterrupted; including the 20 minute rest period. The only non-usual care component will be placement of a sign on the door to discourage visitors and providers from entering the room and disturbing the rest period.
FIELD: recording accessories. SUBSTANCE: the instrument has a reservoir of fiber having ducts and a pen of porous material with ducts providing for passage of ink through it. The composition of ink in the reservoir includes a colored pigmented dispersion and a dispersion of aluminum pigment with particles measuring not more than 12 microns. The pen is contiguous to the reservoir and can absorb the dispersion of aluminum pigment as a result of capillary action. Offered is also the method for making of temporary tattoos on the human skin including the stages of production of the recording instrument having a reservoir of tightly packed polyester oriented fiber with ducts providing for passage of ink through it, as well as of the composition of ink in the reservoir mentioned above. The temporary tattoos representing wipe-off non-transparent "metal" lines are produced by pressing of the recording instrument on the human skin. EFFECT: enhanced reliability of action. 18 cl, 2 dwg, 6 tbl
The invention relates to a Chinese patent medicine for treating skin erysipelas diseases. The Chinese patent medicine is prepared from more than 10 traditional Chinese medicinal materials including radix astragali, rhizoma coptidi, cortex phellodendri, radix scrophulariae, fructus forsythiae and the like. The Chinese patent medicine is a good medicine for treating skin diseases. The Chinese patent medicine is developed on the basis of the traditional Chinese medicine differentiation treatment and in combination with the latest modern achievements in scientific research. The invention aims at providing the Chinese patent medicine for treating the skin erysipelas diseases. The Chinese patent medicine has the advantages of being definite in curative effects, safe and convenient to eat, free of toxic and side effects, and low in price.
1356097 Mineral salt preparations F HOFFMANNLA ROCHE & CO AG 23 Feb 1973 [25 Feb 1972] 9054/73 Heading A5B Mineral salt preparations having delayed electrolyte release for the continuous replacement of mineral salts lost by bodily stress and increased transpiration as well as by the use of diuretics, comprises a matrix suitable for imparting slow-release characteristics and in the form of salts 5 to 80 parts by weight of calcium, 5 to 40 parts by weight of magnesium. 2 to 20 parts by weight of potassium and no sodium of less than 20 parts by weight of sodium; the calcium, magnesium and sodium constituting more than 10% by weight of the preparation. The salts may be the appropriate halides, sulphates, phosphates, glycerophosphates, tartrates, citrates or ascorbates. A preferred preparation contains calcium and magnesium glycerophosphates and sodium and potassium chlorides. The preparations may be administered orally in the form of tablets, drageÚs or capsules and may also contain vitamins C, B 1  and B 6  and/or citric acid. The tablets may have a matrix of natural or synthetic material such as wax, e.g. hardened castor oil.
A pigment suspension is disclosed. The pigment suspension comprises: (a) at least one coloring compound selected from the group of pigments; and (b) a hydroxycarboxylic acid ester. A cosmetic agent is also disclosed. The cosmetic agent comprises the pigment suspension, and one or more organic C1-C6 alkoxysilanes and/or condensation products thereof. A multi-component packaging unit (kit-of-parts) for dyeing keratinous material is also disclosed, and comprises separately packaged first and second containers. The first container comprises an agent (a′), which comprises one or more organic C1-C6-alkoxysilanes and/or condensation products thereof. The second container comprises an agent (a″), which comprises the pigment suspension.
The invention discloses a traditional Chinese medicine pill of yin-nourishing stomach-harmonizing pill, which is prepared from the following components in part by weight: the traditional Chinese medicine composition is prepared from 16 traditional Chinese medicines including dendrobium, citron, coastal glehnia root, dwarf lilyturf tuber, white paeony root, liquoric root, raw rehmannia root, Mongolian snakegourd root, thunberg fritillary bulb, perilla leaf, raw astragalus root, villous amomum fruit, corydalis tuber, Chinese angelica, danshen root and fragrant solomonseal rhizome. 1. Has no influence or little influence on normal physiological functions and no toxic or side effect. 2. The effect is nonspecific and broad-spectrum. 3. Has the normal physiological functions of regulating the normal mechanism of nourishing the stomach of the five internal organs, ascending and descending qi, promoting blood circulation and nourishing stomach yin. It can be used for treating chronic gastropathy due to deficiency of stomach-yin. 4. Can improve symptoms and signs of chronic stomach yin deficiency, eliminate pathogenic factors and strengthen body resistance to recover.
Human tactile memory allows us to remember and retrieve the multitude of somatosensory experiences we undergo in everyday life. An unsolved question is how tactile memory mechanisms change with increasing age. We here use the ability to remember fine-grained tactile patterns passively presented to the fingertip to investigate age-related changes in tactile memory performance. In experiment 1, we varied the degree of similarity between one learned and several new tactile patterns to test on age-related changes in the "uniqueness" of a stored tactile memory trace. In experiment 2, we varied the degree of stimulus completeness of both known and new tactile patterns to test on age-related changes in the weighting between known and novel tactile information. Results reveal that older adults show only weak impairments in both precision and bias of tactile memories, however, they show specific deficits in reaching peak performance > 85% in both experiments. In addition, both younger and older adults show a pattern completion bias for touch, indicating a higher weighting of known compared to new information. These results allow us to develop new models on how younger and older adults store and recall tactile experiences of the past, and how this influences their everyday behavior.
The invention relates to the technical field of functional microorganism screening and application, and particularly provides a novel lactobacillus casei VHProbi F22 strain with a preservation number of CCTCC No: m2019941. The invention also provides application of the lactobacillus casei in regulating intestinal immunity disorder, eliminating DPPH free radicals and degrading cholesterol. The lactobacillus casei VHProbi F22 has strong tolerance to artificial intestinal gastric juice, does not produce hemolysin, does not dissolve blood cells, is sensitive to common antibiotics such as erythromycin, tetracycline and the like, and has good biological safety; can tolerate higher salinity. The strain has strong oxidation resistance and can effectively degrade cholesterol. In addition, the hydrophobicity of the cell surface of the strain is 70.61%, and the strain has certain adhesion capacity. The lactobacillus casei VHProbi F22 can effectively relieve intestinal immune disorder symptoms.