anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain Q-20547 compound having cholecystokinin B/gastrin receptor antagonistic action and usdful e.g. for the treatment and prevention of digestive system diseases and disorders of appestatic system and central nerve system. CONSTITUTION:The Q-20547 compound specified by the plane structural formula expressed by the formula (R is benzyl or isobutyl) or its pharmacologically permissible salt. The compound can be produced by culturing a microbial strain belonging to the genus Aspergillus and capable of producing the Q-20547 compound [e.g. Aspergillus sp. Q20547 (FERM P-13662)] in a medium to effect the production and accumulation of the compound in the cultured product and collecting the compound therefrom. The diseases relevant to the cholecystokinin B/gastrin receptor and effectively curable by the compound are gastric ulcer, duodenal ulcer, gastritis, peptic esophagitis, Zollinger-Ellison syndrome, gastrin sensitive pancreas, anxiety, etc.
For those patients assigned to the ACCURE Navigator, the ACCURE Real-Time Registry is programmed to automatically alert the Navigator when a patient misses a scheduled treatment appointment and to require the Navigator to include details as to how she addressed and resolved that missed appointment, ensuring the ACCURE Navigator's proactive approach to addressing such issues. In addition, a warning message will be produced if no follow-up appointments or procedures are scheduled within 21 days of the index visit.
In older adults, falls are costly, consequential and correlated with both physical and cognitive decline. Most falls occur when standing or walking, especially when completing these tasks in complex environments or while simultaneously performing additional cognitive tasks. To this end, older adults with worse cognitive "executive" function have worse mobility and are more likely to fall.

tDCS (transcranial Direct Current Stimulation) holds promise as a therapy to improve dual task standing and walking and other "high-level" aspects of mobility in older adults. tDCS is a low cost technique, is very safe with only minimal side effects, is portable and is very easy to administer. However, tDCS must be administered numerous times per week for several consecutive weeks in order to induce lasting therapeutic benefit. As each tDCS session must currently be administered in clinical or laboratory settings, such interventions are not currently available to many older adults--especially those who 1) live far away from the clinical/laboratory, and/or 2) have physical and/or cognitive limitations that make it difficult to organize and utilize transportation.

In this project, the investigators propose to demonstrate the feasibility of remotely-monitored, caregiver (or spouse)-administered, home-based tDCS intervention to improve mobility in ambulatory older adults with recent falls. The investigators will do so by completing a three-phase feasibility study in ambulatory older adults at risk of falling due to loss of balance, together with an identified caregiver, using commercially-available tDCS equipment designed for home use. The investigators will utilize a tDCS system called the Starstim Home Kit® (Neuroelectrics Corp). The Starstim Home Kit enables researchers and clinicians to "prescribe" home-based tDCS to end users. Following in-person training sessions, users take home a pre-configured and personalized Starstim system. Phase 1 will involve development of home-based tDCS training materials designed for older adults. Phase 2 will consist of a small, pilot trial to determine numerous factors needed to design a larger, well-controlled trial of home-based tDCS within this population. Phase 3 will further explore feasibility of home-based tDCS, including compliance and retention with the study protocol over a longer time-period.
PURPOSE: Recent studies have suggested that children with an isolated cleft lip (CL) are more likely to develop middle ear disease and eustachian tube dysfunction (ETD) compared to the general population. This may be related to abnormal palatal musculature or an undiagnosed submucosal cleft palate (SMCP). We aim to determine the prevalence of SMCP in patients with CL who exhibit ETD.
MATERIALS AND METHODS: A retrospective chart review was performed for children with an isolated CL requiring tympanostomy tubes over a 20-year period at an academic tertiary care medical center. Demographic, clinical, and surgical data were collected.
RESULTS: Three hundred twelve patients had an isolated CL, and 29 (9.3 %) children required tympanostomy tubes. Of those, nine (31 %) were found to have a SMCP (7 males, 6 Caucasian). The average age at CL repair was 3.94 ± 1.03 months, and the average age at tympanostomy tube placement was 13.68 ± 13.8 months. All nine patients had chronic otitis media, with four having mild conductive hearing loss and three having moderate conductive hearing loss. The SMCP was diagnosed at the time of CL diagnosis (4), after CL diagnosis with the diagnosis of chronic otitis media/ETD (2) and after a diagnosis of chronic otitis media/ETD.
CONCLUSION: Middle ear disease or eustachian tube dysfunction in a patient with an isolated cleft lip should raise suspicion for an accompanying undiagnosed SMCP.
The invention provides a unique formulation of short chain, medium chain, long chain and very long chain saturated, unsaturated, non-essential, and essential fatty acids that conform to the full spectrum of fatty acids required for normal cell membrane maintenance and function. The oil composition can lower LDL cholesterol levels while normalizing levels of key biochemical diagnostic metabolites in the human body. The mixture's stability, digestibility and potency are maintained with limonene and menthol. The nutritional fatty acid supplement can be incorporated as a delivery agent of pharmaceuticals and biochemicals or the formulation can be added into salads, infused into gel pill formats and as additives in food products. The formulation can be used topically for alleviating certain skin disorders such as skin rashes (eczema and seborreah dermatitis). The mixture can be of beneficial use for people with autism, ADHD, mental health related issues and general cardiovascular and metabolic disorders.
Pyruvate Dehydrogenase (PDH) E2 deficiency due to Dihydrolipoamide acetyltransferase (DLAT) mutations is a very rare condition with only nine reported cases to date. We describe a 15-year-old girl with mild intellectual disability, paroxysmal dystonia and bilateral basal ganglia signal abnormalities on brain magnetic resonance imaging (MRI). Additionally, neurophysiological, imaging, metabolic and exome sequencing studies were performed. Routine metabolite testing, and GLUT1 and PRRT2 mutation analysis were negative. A repeat brain MRI revealed 'Eye-of-the-tiger-sign'. Exome sequencing identified homozygous valine to glycine alteration at amino acid position 157 in the DLAT gene. Bioinformatic and family analyses indicated that the alteration was likely pathogenic. Patient's dystonia was responsive to low-dose carbamazepine. On weaning carbamazepine, patient developed hallucinations which resolved after carbamazepine was restarted. PDH E2 deficiency due to DLAT mutation has a more benign course compared to common forms of PDH E1 deficiency due to X-linked PDHA1 mutations. All known cases of PDH E2 deficiency due to DLAT mutations share the features of episodic dystonia and intellectual disability. Our patient's dystonia and hallucinations responded well to low-dose carbamazepine.
Healthy non-operated control subjects, matched on BMI, age and sex. These subjects will undergo an oral glucose tolerance test (OGGT), an isoglycemic intravenous glucose infusion (IIGI) and a 300 kcal liquid mixed meal.
Novel 5,10-seco-steroids of the formulae <FORM:1065432/C2/1> <FORM:1065432/C2/2> (wherein R and R3 are each two hydrogen atoms, an oxo group or a hydrogen and an a - or b -hydroxyl group; R1 and R5 each is an oxo group or an alkylenedioxy group of at most 4 carbon atoms or a hydrogen and an a - or b -free, esterified or etherified hydroxyl group; R2 is oxo, or alkylenedioxy of at most 4 carbon atoms, or hydrogen or an aliphatic hydrocarbon radical of at most 6 carbon atoms and a b -free, esterified or etherified hydroxyl group; R4 and R6 each is hydrogen or a free, esterified or etherified hydroxyl group; and X is hydrogen, fluorine, chlorine or bromine) and their 1(10)-dehydro derivatives, and the 4(5)-dehydro and 1(10), 4(5)-bisdehydro derivatives of the 5-unsubstituted compounds; are prepared by reacting a corresponding 5-hydroxy steroid that contains no further oxidizable hydroxyl group with an oxidizing tetravalent lead acylate or with a compound that contains monovalent positive iodine and, if desired, in the resulting 5-oxo-5,10-seco-D 1(10)-steroids the double bond and/or the oxo group is hydrogenated and/or any protected hydroxyl or oxo groups are liberated and/or any free oxo group is eliminated and/or a 5-hydroxyl group is eliminated to form a D 4-double bond and/or free hydroxyl groups are esterified or etherified. Resulting 5-hydroxy steroids can be re-oxidized to the 5-ketones.  5-Hydroxy-steroids used as starting materials are prepared by reducing 5,6-oxido-steroids. Any free oxo groups reduced in this process are subsequently re-formed by oxidation.  The 5-10-seco-steroids of the invention, which are stated to be useful as androgens, anabolics, progestatives and as agents capable of regulating the mineral metabolism and the blood cholesterol level, may be made up into pharmaceutical or veterinary compositions with suitable carriers, for parenteral, enteral or local administration. They may contain preserving, stabilizing, wetting or emulsifying agents, salts for regulating the osmotic pressure, or buffers.
It is known that newborns have similar brain activity in the intrauterine period and REM sleep activity, and they sleep more than adults and spend most of their sleep in the REM sleep period. Therefore, sleep quality in the newborn period is directly related to healthy development. Providing a developmentally supportive position in neonatal intensive care units (NICU) is necessary not only for neuromotor and musculoskeletal development, but also for physiological function and stability, thermal regulation, bone density, neurobehavioral organization, calmness and comfort, skin integrity, optimal musculoskeletal development, facilitation of sleep, growth and brain development. Excessive noise in the NICU, prolonged bright lights, separation from the mother, frequent invasive procedures and pain experience are among the factors that disrupt, shorten and create stress in the sleep duration of preterm babies. It is very important to support the sleep of preterm babies in the NICU in order to improve their growth and development, especially their brain development. It is known that therapeutic positions, which are one of the individualized developmental care practices, are effective on sleep.This study was conducted to compare the effectiveness of three stair positioning pillows and positioning materials on the sleep-wakefulness status of preterm infants.
PURPOSE: To evaluate the awareness and existing knowledge of a portion of the Greek population about prevention, screening, and HPV vaccination.
METHODS: A questionnaire designed in Google forms has been distributed through social media between June 2021 and December 2021 in men and women aged > 16 years old. Statistical analysis was performed using the SPSS 20.0 program. Inferential analysis was performed to evaluate differences in responses among men and women.
RESULTS: We enrolled 2685 participants. Of those, 2285 were women, 386 were men, while 14 respondents chose not to respond to this question. Various age groups were detected with those aged between 26 and 30 years old being the predominant one. Participants with a higher education constituted 36.5% of the population. Most respondents were married (59.8%). In socioeconomic terms 75.5% of participants were employed whereas, monthly income ranged between 1000 and 1500 euros in the predominant group (36.8%). Only 40% of females and 3.9% of males were vaccinated against HPV. Adolescent immunization, acceptability rates reached 92.7% among female and 82.1% among male responders. Although, only a small proportion of the participants were not aware of the existence of HPV, 24.1% of males and 23.4% of females had the impression that condom use may provide absolute immunity to HPV and only 51.6% of males and 60.4% of females were aware about the high prevalence of HPV in the general population. Logistic regression analysis indicated that male participants as well as those aged > 50 years and those choosing to reject vaccination had decreased knowledge of the basic pathophysiology of HPV infection, as well as knowledge related to the existence and use of HPV DNA as a screening tool and the existence and efficacy of HPV vaccination.
CONCLUSION: Our results indicate that although awareness of the existence of HPV infection is high in Greek general population, the actual perception of the pathophysiology of transmission and importance of HPV testing and vaccination is low. Targeting specific population groups is essential to help increase HPV coverage and screening.
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for determining an efficacy of music therapy are provided. An example system initiates a music therapy session for a patient on a music therapy device. The system provides the patient with a predefined type of music during the music therapy session at a pre-defined volume. The system ends the music therapy session. The system then receives a request to determine an efficacy of music therapy sessions for the patient for a defined time period and obtains personal and listening metrics associated with the patient's music therapy sessions for the defined time period. The system correlates the personal and listening metrics with the patient's medical metrics for the defined time period in order to determine the efficacy of music therapy sessions for the patient.
Novel pyridazino[4,5-b][1,5]oxazepinone, thiazepinone and diazepinone derivatives of general formula (I) wherein: R stands for hydrogen atom or a group of formula NHR4, wherein: R4 stands for hydrogen, C¿1-4? alkyl or C2-5 acyl group, R?1¿ stands for C¿1-4? alkyl or C2-4 alkenyl group, which may be substituted by a phenyl group, or phenyl group, W stands for methylene or carbonyl group, X and Y stand independently for oxygen or sulphur atom, SO, SO2 or NR?3¿ group, wherein R3 is hydrogen atom, C¿1-4? alkyl group or a group of formula (II), wherein R?2¿ stands for hydrogen or halogen atom, C¿1-4? alkoxy or nitro group or a group of formula NHR?4¿, wherein R4 has the above meaning, and Z stands for methylene or carbonyl group, further n has a value of 0, 1 or 2, with the proviso that when any of X or Y stands for oxygen or sulphur atom, SO or SO¿2? group or a group of formula NR?3¿, wherein R3 stands for hydrogen atom or C¿1-4? alkyl group, then the other may stand only for an NR?3¿ group, wherein R3 stands for a group of formula (II) - wherein R2, Z and n have the above meanings - and their tautomers and the acid-addition salts of all these compounds. The compounds according to the invention show memory-enhancing and neuroprotective properties.
The human gastrointestinal tract is home to an extremely numerous and diverse collection of microbes communities, collectively termed the "intestinal microbiota". This amazingly complex and poorly understood group of communities has an enormous impact on humans. Indeed, microbiota is considered to play a number of key roles in the maintenance of host health, including aiding digestion of otherwise indigestible dietary compounds, synthesis of vitamins and other beneficial metabolites, immune system regulation and enhanced resistance against colonization by pathogenic microorganisms. Conversely, the intestinal microbiota is also a potent source of antigens and potentially harmful compounds. Schematically, humans can be considered to exist in a state of natural balance with their microbial inhabitants. A shift in the balance of microbiota composition such that it may become deleterious to host health is termed "dysbiosis". Dysbiosis of the gut microbiota has been implicated in numerous disorders, ranging from intestinal such as inflammatory bowel diseases and colorectal cancer to disorders with more systemic effects such as diabetes, obesity, insulin resistance and steatohepatitis. The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer but, because of the complexity of the microbial community, the functional connections are less well understood.

In humans and animals, bariatric surgery (mainly gastric bypass surgery) lead to alterations of gut microbiota, which seem to be favourable. In this study the investigators aim to examine the effect of different bariatric procedures on composition of gut microbiota.
Duchenne muscular dystrophy (DMD) is an inherited disease characterized by progressive degeneration of the skeletal muscles. Renal dysfunction in patients with DMD has recently become more apparent as life expectancy has increased owing to advances in respiratory devices and heart failure therapies. A 23-year-old man with DMD who required nasal tube feeding was referred to our hospital with a 4-month history of renal dysfunction and anemia. The patient's serum creatinine (sCr) level was within the normal range (0.84 mg/dL), but his serum cystatin C level and estimated glomerular filtration rate calculated by cystatin C (5.90 mg/L and 7.5 mL/min/1.73 m2, respectively) indicated severe renal impairment. A urinalysis revealed elevated levels of protein and tubular markers. The patient's hemoglobin and erythropoietin levels indicated renal anemia. Hypotension, a collapsed inferior vena cava, and a poor tube feeding episode suggested that the kidney injury was due to renal ischemia, which progressed to tubulointerstitial kidney injury, an intrinsic kidney injury. The angiotensin-converting enzyme inhibitors and beta-blockers were discontinued, and extracellular fluid was infused. Thereafter, the patient's renal function recovered. Subsequently, the patient's urinary findings and anemia improved. Although advances in cardioprotective agents are expected to improve the prognosis of patients with DMD, it is important to consider that the number of patients with kidney injury due to renal ischemia may increase and that it is difficult to evaluate renal function using sCr level in patients with DMD because of decreased skeletal muscle mass.
Participants with moderate hepatic impairment (bilirubin \> 1.5-3 x ULN, any AST) received carfilzomib 20 mg/m² administered by intravenous (IV) infusion on days 1 and 2 of cycle 1, followed by a planned step-up to 27 mg/m² IV on days 8, 9, 15, and 16 of cycle 1. Participants who adequately tolerated dosing at 27 mg/m² in cycle 1 received carfilzomib 56 mg/m² IV on days 1, 2, 8, 9, 15, and 16 of cycle 2 and subsequent 28-day cycles until confirmed progressive disease (PD), unacceptable toxicity, withdrawal of consent, study closure, or death.
The control group enters directly into the HLP without any other study visits. The HLP includes physical activity monitoring (step count, calories burned and sleep) with the Garmin vívofit 4 Activity Tracker, and recording and monitoring of goals with the My Goals app. Moreover, participants will be offered an exercise program with weaning to community-based resources and home exercise recommendations for longer-term sustainability.
PURPOSE:To obtain an antifungal composition for nails which can effectively cure tinea unguium with film formation on the nail, by adding an antifungal agent to a base which is composed of polyvinyl acetate, esters of long-chain fatty acids of 8-20C and/or higher alcohol of 8-20C and a volatile solvent. CONSTITUTION:The subject composition is composed of (A) 3-35pts.wt., per 100pts.wt. of the whole composition, of a polyvinyl acetate of 300-8,000 average polymerization degree, (B) 0.2-5pts.wt. of an antifungal, preferably an imidazole antifungal, (C) 0.1-4pts.wt. of esters of long-chain fatty acids of 8-20C and/or higher alcohol of 8-20C, and (D) 56-96.7pts.wt. of a volatile solvent. The composition is coated on the nail to form a film whereby the affected part is tightly sealed to swell the nail and promote the impregnation of the antifungal into nails. Simultaneously the composition can release the antifungal for a long time to enhance curative effect, whereby application times can be reduced.
We studied the effect of Refralon on the electrophysiological properties of the supraventricular myocardium against the background of adrenergic (epinephrine) influence in the zone of the pulmonary veins, the area where 50-90% of atrial arrhythmias is triggered. The experiments were carried out on isolated tissue preparations of Wistar rats. The multichannel microelectrode array technique was used to record action potentials simultaneously in the atrium and in the ostium and distal parts of the pulmonary veins. Epinephrine application (12-50 nM) led to depolarization of the resting potential and the conduction block in the distal part of the pulmonary veins. Refralon (30 μg/kg) restored the resting potential in the distal part of the pulmonary veins. Against the background of epinephrine, Refralon did not significantly change the duration of the action potential at 90% repolarization in comparison with control. At the same time, the comparison drug E-4031 against the background of epinephrine significantly increased the duration of action potential in the atrium and in the ostium of the pulmonary veins, and sotalol increased it only in the ostium. Neither E-4031, nor sotalol restored conduction in their distal part. Refralon has a biphasic effect under conditions of adrenergic stimulation: the fast component is responsible for stabilizing the resting potential in the pulmonary vein and reduces the dispersion of action potential duration in the atrium and pulmonary vein and is also quickly washed away, and the slow component is responsible for the increase of the action potential duration and is slowly washed away.
PURPOSE OF REVIEW: Current treatment options for cholangiopathies are severely limited and there is thus a critical need to identify and develop therapies. This review discusses the role of integrins in biliary injury and fibrosis and their potential as therapeutic targets.
RECENT FINDINGS: There are a diverse set of roles that integrins play in biliary injury and fibrosis. Some integrins activate TGF-β signaling or are involved in sensing of the extracellular matrix, making them attractive targets for biliary fibrosis. In recent work, autoantibodies to α v β 6 were identified in patients with PSC, supporting the relevance of this integrin in the disease. In addition, a role for α 2 β 1 in cyst formation was identified in a mouse model of polycystic liver disease. Leukocyte integrins (e.g. α E β 7 and α 4 β 7 ) contribute to lymphocyte trafficking, making them potential targets for biliary inflammation; however, this has not yet translated to the clinic.
SUMMARY: While all members of the same family of proteins, integrins have diverse roles in the pathogenesis of biliary disease. Targeting one or multiple of these integrins may slow or halt the progression of biliary injury and fibrosis by simultaneously impacting different pathologic cells and processes.
Participants with 3L renal clear cell carcinoma (RCC) will receive TAK-500, infusion, intravenously, in a 42-day treatment cycle (Q2W or Q3W) with pembrolizumab 200 mg infusion, intravenously, in a 42-day treatment cycle (Q3W) for up to 1 year. The recommended dose (RDE 1) and schedule of TAK-500 for expansion will be based on the results of the TAK-500 in combination with pembrolizumab Dose Escalation arm.