anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Several types of cancer cells are treated with specialized therapies, as they have specific properties such as steroid-dependant, especially estradiol-dependant growth. Breast cancer and colon cancer cells often depend to some extend on estradiol-mediated growth signals. Therefore, especially breast cancer patients are routinely tested for the presence of estradiol receptors by immune histology. If the estradiol receptor is present usually an anti-estradiol therapy is used to eradicate the tumour and to prevent rezidives. However to a certain extend this therapy does not work and it would be an advantage to know this as early as possible, thereby not to loose any time with wrong therapy concepts. Therefore a better predictive marker to diagnose steroid-dependant cancer cells is necessary, which is provided by this invention. Prothymosin alpha (PTA) can be measured in tissue samples and plasma of breast cancer and colon cancer patients and indicates, whether the estradiol pathway is functional and consequently whether anti-estradiol therapy may be successful. PTA can be a surrogate for estradiol receptor detection by immune histology, can be a marker to monitor resistance of cancer cells towards anti-estradiol therapy and has the advantage to be determined from easily accessible patient samples such as serum or plasma. Claimed are PTA peptides and nucleic acids, binding agents therefore, test kits and diagnostic and therapeutic methods and compositions.
Embodiments described herein relate to a robotic companion device for assisting a patient with daily tasks and/or medical emergencies. A robotic companion device may have sensors, actuators, and a computer system. The robotic device maybe able to receive sensor data, such as environmental information and a patient location. As the robotic device receives more data, it can learn (i.e., update decision tables) from the environment or patient in order to guide future actions. Additionally, based on the received sensor data, the robotic device is able to determine whether an emergency situation has occurred related to one or more patients and move to an area adjacent to the patient. Once near the patient, the robotic device can transmit a communication to a third party alerting them of the emergency situation. To improve patient interactions, the robotic device may mimic the gender, voice, lip movement, or facial appearance of a familiar individual.
The emergence and spread of novel viral pathogens is a major threat to human health, particularly in the context of climate and human-induced change in land use. Alongshan virus (ALSV) is a tick-borne virus associated with human disease, which was first identified in northeast China. More recently, several studies reported the emergence of ALSV in mammalian and arthropod hosts in multiple different countries outside of Asia, and the first viral genome sequencing data has become available. ALSV is a member of the Jingmenvirus group closely related to the Flaviviridae family. Unusually, the positive-sense, single-stranded RNA genome of ALSV is segmented and consists of four distinct segments, two of which show homology with the NS3 and NS5 protein encoding regions of non-segmented flaviviruses. Transmission of arthropod-borne pathogens will likely increase in the future due to environmental change mediated by a variety of environmental and ecological factors and increasing human encroachment into wild animal habitats. In this review, we present current knowledge of global ALSV distribution and emergence patterns, highlight genetic diversity, evolution and susceptible species. Finally, we discuss the role of this emerging tick-borne virus in the context of urbanization and global health.
The use of radiation therapy to treat pelvic and abdominal cancers can lead to the development of either acute or chronic radiation enteropathy. Radiation-induced chronic colonic fibrosis is a common gastrointestinal disorder resulting from the above radiation therapy. In this study, we establish the efficacy of inulin supplements in safeguarding against colonic fibrosis caused by irradiation therapy. Studies have demonstrated that inulin supplements enhance the proliferation of bacteria responsible to produce short-chain fatty acids (SCFAs) and elevate the levels of SCFAs in feces. In a mouse model of chronic radiation enteropathy, the transplantation of gut microbiota and its metabolites from feces of inulin-treated mice were found to reduce colonic fibrosis in validation experiments. Administering inulin-derived metabolites from gut microbiota led to a notable decrease in the expression of genes linked to fibrosis and collagen production in mouse embryonic fibroblast cell line NIH/3T3. In the cell line, inulin-derived metabolites also suppressed the expression of genes linked to the extracellular matrix synthesis pathway. The results indicate a novel and practical approach to safeguarding against chronic radiation-induced colonic fibrosis.
BACKGROUND: Renal transplantation is the gold-standard therapy for end-stage renal disease. Decision-making around the acceptance of deceased-donor organs is complex and time sensitive. Risk scoring systems for both donors and recipients attempt to simplify the allocation of renal grafts to the most appropriate recipient.
OBJECTIVES: To investigate the role of these transplant risk scores in the South African (SA) setting.
METHODS: A total of 188 adult deceased-donor organ referrals over the 9-year period 1 January 2013 - 31 December 2021 were included. The Kidney Donor Risk Index (KDRI) and the UK KDRI were calculated for each donor. Recipients who were allocated these grafts were characterised, and the Hennepin Transplant Risk Score and the Kidney Transplant Morbidity Index (KTMI) were calculated.
RESULTS: The median (interquartile range) KDRI was 1.2 (0.9 - 1.6), confirming that low- to average-risk donors were being utilised. Similarly, the median UK KDRI was 0.9 (0.8 - 1.2). Both these scores performed poorly in predicting graft and patient survival, with a C-statistic of 0.5. Renal recipient risk scores also demonstrated low- to average-risk patients being transplanted, with a median Hennepin score of 2 - 4 points and a KTMI of 2 points. These recipient scores predict increased recipient mortality at high scores, albeit with low sensitivity, and were not significantly associated with graft survival.
CONCLUSION: Deceased-donor and renal recipient risk scores commonly used internationally performed poorly in predicting graft survival in our cohort, and should be used with caution in the SA setting. A conservative approach to organ donor referral and utilisation as well as renal transplant recipient listing was noted.
A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxicischemic and other diseased neurologic tissue during treatment are provided.
The dynamic relationship between heart failure and cancer poses a dual challenge. While cardiac remodeling can promote cancer growth and metastasis, tumor development can ameliorate cardiac dysfunction and suppress fibrosis. However, the precise mechanism through which cancer influences the heart and fibrosis is yet to be uncovered. To further explore the interaction between heart failure and cancer, we used the MDX mouse model, which suffers from cardiac fibrosis and cardiac dysfunction. A previous study from our lab demonstrated that tumor growth improves cardiac dysfunction and dampens fibrosis in the heart and diaphragm muscles of MDX mice. We used breast Polyoma middle T (PyMT) and Lewis lung carcinoma (LLC) cancer cell lines that developed into large tumors. To explore whether the aggressiveness of the cancer cell line is crucial for the beneficial phenotype, we employed a PyMT breast cancer cell line lacking integrin β1, representing a less aggressive cell line compared to the original PyMT cells. In addition, we examined immortalized and primary MEF cells. The injection of integrin β1 KO PyMT cancer cells and Mouse Embryo Fibroblasts cells (MEF) resulted in the improvement of cardiac function and decreased fibrosis in the heart, diaphragm, and skeletal muscles of MDX mice. Collectively, our data demonstrate that the cancer line aggressiveness as well as primary MEF cells are sufficient to impose the beneficial phenotype. These discoveries present potential novel clinical therapeutic approaches with beneficial outcome for patients with fibrotic diseases and cardiac dysfunction that do not require tumor growth.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to radiopharmaceutical preparation containing radionuclide samarium-153 that can be used for treatment of patients with malignant neoplasm metastasis in bone and rheumatic arthritis. Claimed agent is the radiopharma-ceutical composition containing samarium= 153 where samarium presents as complex with oxa-bis-(ethylenenitrilo)-tetra-methylene phosphonic acid or its physiologically acceptable salt, sodium chloride, water for injection taken in the definite ratio of components. Volume activity of samarium-153 is 240-740 MBcq/ml and value pH of composition = 5.0-7.0. EFFECT: simplified preparing, enhanced therapeutic effect, absence of toxic responses patient body. 2 tbl, 6 ex
Experimental：Group Ziyinxiehuo Granules and Megestrol Acetate Tablet Intervention :Subjects in Group Ziyinxiehuo Granules and megestrol acetate tablet will be treated with Ziyinxiehuo Granules and megestrol acetate tablet for 6 months.1 pack of Ziyinxiehuo granules Herbs includes shengdi 5g, xuanshen 3g, zexie 3g, zhimu3g, huangpai 3g, zhiguiban 2g, maiya 6g,tiandong 3g, zhigancao 2g. Ziyinxiehuo Granules is administered after dissolved,1pack every time, 2 times per day after a meal; and the dosage of megestrol acetate is 6-8mg/d, which is taken in 3 times after a meal.
The invention discloses a hair loss preventing and hair growing composition, and belongs to the technical field of daily chemicals. The preparation method adopts a powder-liquid mixing mode, keeps the activity of polypeptide and collagen, and pours the solvent liquid into the freeze-dried powder for dissolving and cleaning for use. Mannitol is used as excipient of freeze-dried powder; the copper peptide promotes scalp blood circulation and nutrient supply; acetyl tetrapeptide-3 promotes hair anchorage in hair follicles; the placenta protein can repair skin injury and tissue reconstruction, and promote hair growth. The lyophilized powder has multiple nutritional hairs, so that the hair follicle finishes the resting period and enters the growth period to promote the growth of hair papilla; the solvent helps the raw materials dissolve, and is beneficial for scalp absorption of the raw materials. The freeze-dried powder and the solvent liquid are mixed in proportion, and the hair-growing cream has the effects of preventing hair loss and promoting hair growth. The hair growth beneficial components such as multiple polypeptides and proteins are compounded to supplement scalp nutrient components, so that the hair growth composition is beneficial to the nutrition of hair, the hair follicle in a dormant state for a long time is beneficial to reviving and growing, and the hair regrowth is promoted.
CSD patients were treated with vaginal repair of CSD in combination with metformin (Boke, 500 mg, Wanhui Shuanghe, Beijing, China) as an oral medicine (abbreviated as VR + metformin). In the group of VR + metformin, the patients start oral metformin from one month before the operation to 6 months after the operation. The dose is 500mg twice a day. The detailed procedure of VR has been described in investigators' previous study.
CNS stimulants, such as RELEXXII, used to treat ADHD are associated with peripheral vasculopathy, including Raynaud’s phenomenon. Signs and symptoms are usually intermittent and mild; however, sequelae have included digital ulceration and/or soft tissue breakdown. Effects of peripheral vasculopathy, including Raynaud’s phenomenon, were observed in post-marketing reports and at the therapeutic dosage in all age groups throughout the course of treatment. Signs and symptoms generally improved after reduction or discontinuation of the CNS stimulant. 

Careful observation for digital changes is necessary during RELEXXII treatment. Further clinical evaluation (e.g., rheumatology referral) may be appropriate for RELEXXII-treated patients who develop signs or symptoms of peripheral vasculopathy.
BACKGROUND: Curved varus osteotomy (CVO) is an effective femoral head-preserving surgical procedure for osteonecrosis of the femoral head (ONFH) classified as type B or C1 according to the Japanese Investigation Committee (JIC) classification; it reportedly provides better postoperative outcomes than transtrochanteric rotational osteotomy (TRO). We have developed a new procedure called spherical varus rotational osteotomy (SVRO) in which osteotomy of the femur into a spherical shape is followed by varus and anterior rotation using navigation to increase indications and improve postoperative outcomes.
METHODS: Nine joints of eight patients who underwent SVRO and could be followed up for > 1 year were included in the study. Disease types determined preoperatively according to the JIC classification were type C1 for four joints and type C2 for five joints. Preoperative disease JIC classification stages were 3a for eight joints and 1 for one joint. SVRO was performed using OrthoMap® 3D Navigation software, and the following variables were measured: surgery time, intraoperative blood loss, difference between preoperative and postoperative angles of anteversion, postoperative lower limb length discrepancy, and postoperative intact area occupancy. The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) was used for clinical evaluation. Visual Analog Scale and JHEQ scores were evaluated preoperatively and at the final follow-up.
RESULTS: The measurement results were as follows: surgery time, 130 min; blood loss, 200 ml; angle of varus, 20°; angle of anterior rotation, 30°; preoperative angle of anteversion, 15°; postoperative angle of anteversion, 22°; lower limb shortening, 11 mm; preoperative intact area occupancy, 0%; and postoperative intact area occupancy, 74.2%. There were no cases of progression in the postoperative stages or re-collapse.
CONCLUSION: SVRO allows for the repositioning of the exterior and posterior intact areas, providing a broader intact region postoperatively. This technique is particularly beneficial for young patients with ONFH and extensive necrosis and is a less invasive alternative to TRO. This procedure has been shown to be effective in achieving favorable outcomes in patients with extensive necrosis who would have otherwise required rotational osteotomy, depending on the necrosis location. Further longitudinal studies are necessary to validate these findings and establish long-term benefits.
Receiving ramipril with the recommended initial dose of 2.5 mg once daily; depending on the tolerability, the dose should be gradually increased. The increase should be implemented by doubling the dose after one to two weeks. Three or four weeks later, the dose should be doubled again up to the usual maintenance dose of 10 mg once daily.
Pouchitis is an acute or chronic inflammatory disease of the ileal reservoir. It is common after restorative proctocolectomy with ileal pouch-anal anastomosis, and treatment of chronic antibiotic-refractory pouchitis has proven challenging. Most cases of acute pouchitis evolve into chronic pouchitis. The aetiology of acute pouchitis is likely to be partly related to the gut microbiota, whereas the pathophysiology of chronic pouchitis involves abnormal interactions between genetic disposition, faecal stasis, the gut microbiota, dysregulated host immunity, surgical techniques, ischaemia and mesentery-related factors. Pouchoscopy with biopsy is the most valuable modality for diagnosis, disease monitoring, assessment of treatment response, dysplasia surveillance and delivery of endoscopic therapy. Triggering or risk factors, such as Clostridioides difficile infection and use of non-steroidal anti-inflammatory drugs, should be modified or eradicated. In terms of treatment, acute pouchitis usually responds to oral antibiotics, whereas chronic antibiotic-refractory pouchitis often requires induction and maintenance therapy with integrin, interleukin or tumour necrosis factor inhibitors. Chronic pouchitis with ischaemic features, fistulae or abscesses can be treated with hyperbaric oxygen therapy.
The present invention addresses substituted pyridyl pyrroles, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists and inhibitors of the biosynthesis and action of TNF-.alpha. and IL1. The compounds block the action of glucagon at its receptors and thereby decrease the levels of plasma glucose. The instant pyrroles are also inhibitors of TNF-.alpha. and IL1 and may be used as antidiabetic agents as well as other cytokine mediated diseases. Cytokine mediated diseases refer to diseases or conditions in which excessive or unregulated production of one or more cytokines occurs.  Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) are cytokines produced by a variety of cells, which are involved in immunoregulation and other physiological conditions, such as inflammation.
A treatment tool may generate and transmit a predetermined bioactive frequency and/or waveform of electromagnetic energy and/or acoustic energy into a given region of treatment for inducing a particular cellular outcome/behavior of at least one targeted cell selected from the region of treatment. The region of treatment may be at least a single organism or portion thereof. The region of treatment may include other different types of cells in addition to the at least one targeted cell. The treatment tool may be used in vivo, non-invasively, and selectively, wherein the particular cellular outcome/behavior occurs in the at least one targeted cell but not other cells. The treatment tool may have a transmitter assembly, an antenna tuner, an attenuator, a broadband power amplifier, and a frequency/waveform generator; and the treatment tool may also have a computer. The treatment tool may be used to treat cancers and/or other conditions.
CAST is a transdiagnostic cognitive behavioral therapy (CBT)-based protocol designed to address elevated anxiety sensitivity (AS), particularly the amplification of cognitive stress symptoms including perceived confusion and memory problems. CAST is a fully computerized, 1-hour intervention containing video animation and audio narration throughout, as well as interactive features (e.g., brief quizzes to promote comprehension, introduction and practice with interoceptive exposures). Procedures draw heavily on standard CBT techniques; AS, a core vulnerability for anxiety and depression is targeted using these procedures. In CAST, participants are informed that "the primary purpose of the presentation is to highlight healthier, more productive, and effective ways of dealing with stress." Through participation in the intervention, people learn adaptive long-term strategies for tolerating, coping with, and effectively reducing distress and negative emotions.
Nursing education is an education system structured in order to provide the student with a professional nursing identity and to prepare the student for professional life, where theoretical and practical education is offered as a whole. In this system, nursing students are expected to acquire cognitive, affective and psychomotor skills at a very good level. Teaching process of psychomotor skill; It enables students to practice, analyze and develop skills by analyzing the theoretical information they have learned, to establish a relationship between theory and practice, to develop critical thinking and problem solving skills, to make regular observations and to gain a sense of trust . Today, with the development of technology and changing needs, there are also changes in the methods of education and training commonly used. One of the educational methods developed with technology is the video model method. Videos are among the important technologies that add value to the learning content. The use of video helps students learn new skills and improve their learning processes in the same way they have experience during practical training . Using videos while teaching nursing skills is as effective as demonstration as it provides visuality. Using a properly formatted video to teach a particular nursing skill allows a student to learn physical action that complements the theory behind skill and action. The use of training based on the video model method is useful for applications of nursing skills based on flexibility and capacity for students to review, reflect and repeat recordings . When the studies using video method in nursing education are examined; Lee et al. (2016) first shot a urinary catheterization skill video to teach nursing second grade students about urinary catheterization skills. Later, the experimental group (n = 36) was trained by mobile-based video learning and the control group students (n = 35) by the demonstration method. All students attended a 90-minute course on urinary catheterization and all students watched the urinary catheterization skill video. Students in the control group only watched the one-time video, students in the experimental group had the opportunity to watch the video for seven days on their mobile devices. A week later, students in the experimental and control groups performed urinary catheterization skill in the skill laboratory. At the end of the application, students' learning motivation, skill performance score, application confidence and skill laboratory satisfaction were evaluated. It was found that students in the experimental group had higher motivation to learn, skill laboratory satisfaction, knowledge and skill performance score and application confidence compared to the control group . Gowri, Minolin and Thenmozhi (2013) conducted a semi-experimental study in order to teach obstetric palpation skills to nursing second year students in antenatal period.