anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: pharmaceuticals.SUBSTANCE: group of inventions relates to the field of pharmaceuticals, namely to an oral composition for targeted delivery of cholestyramine to the colon. The oral composition for targeted delivery of cholestyramine to the colon is comprised of: a) multiple moulded and spheronised pellets containing at least 70% wt./wt. cholestyramine and at least 7% wt./wt. vinylpyrrolidone-based polymer, or a combination of at least 6% wt./wt. vinylpyrrolidone-based polymer and at least 2% wt./wt. acrylate copolymer, or a combination of at least 5% wt./wt. vinylpyrrolidone-based polymer and at least 3% wt./wt. acrylate copolymer, or a combination of at least 6% wt./wt. vinylpyrrolidone-based polymer and at least 1% wt./wt. acrylate copolymer and at least 10% wt./wt. microcrystalline cellulose; and b) a diffusion-controlled inner coating around said pellets; and c) an outer enteric coating. The group of inventions also relates to an application of such composition in treatment or prevention of bile acid malabsorption and bile acid diarrhea.EFFECT: invention allows to reduce the dosage of cholestyramine and prevents pellets from being released before reaching the colon, reducing undesirable interactions of cholestyramine with other components in the gastrointestinal tract, such as other medicinal products or nutrients.22 cl, 4 dwg, 2 tbl, 7 ex
BACKGROUND: Laparoscopic anterior rectal resection (LAR) is a commonly performed surgery for rectal cancer patients. Pelvic floor peritoneum closure (PC), a vital procedure in conventional anterior rectal resection, is not routinely performed in LAR.
STUDY DESIGN: A total of 1118 consecutive patients with rectal cancer receiving LAR were included in this retrospective study. Patients were allocated into the PC group and the non-PC group. The occurrence of postoperative complications was compared between the 2 groups. Influential factors in anastomotic leakage (AL) were explored using univariate and multivariate logistic regression.
RESULTS: There was no difference between the groups in terms of baseline characteristics. The occurrence of postoperative complications was similar between the groups. The PC group had significantly shorter postoperative hospitalization and longer operation duration compared with the non-PC group. The occurrences of Clavien-Dindo (CD) III-IV complications, CD III-IV AL, and reoperation were significantly lower in the PC group than the non-PC group. PC and a protective ileostomy were independent protective factors for CD III-IV AL.
CONCLUSION: PC could reduce the occurrence of CD III-IV complications, especially CD III-IV AL, and the rate of secondary surgery, especially in patients with a lower body mass index and patients who did not receive protective ileostomies.
PURPOSE: A patch and patch preparation are provided to prevent denaturation of active ingredients and the movement of active ingredients. CONSTITUTION: A patch contains a support and pressure sensitive adhesive layer. The pressure sensitive adhesive layer is contained on at least one side. The pressure sensitive layer contains monomers and acrylic polymers. The monomer is at least one kinds of methacrylic aic alkyl ester. The content of the methacrylic acid alkyl ester monomer is 50-90 weight%.
<P>PROBLEM TO BE SOLVED: To provide a low-irritant and highly safe surface modifier for a denture for preventing, ameliorating or relieving various symptoms caused by dryness in the oral cavity.  <P>SOLUTION: The surface modifier for the denture is characterized as comprising sericin. Wettability of the denture base surface is improved and a reduction in a sense of incompatibility and a pain and a moist feeling in the oral cavity during mounting of the denture are obtained. The sericin has high biocompatibility and is tasteless and odorless. Thereby, the low-irritant and highly safe surface modifier for the denture can be provided. The effects can further be improved by using the sericin and a vegetable extract and/or a polyhydric alcohol in combination.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Embodiments described herein provide systems and methods for improving diagnosis, screening, and treatment of patients. The disclosed systems and methods generally relate to artificial intelligence (AI) based deep learning models that can help with decision making, for example, in gynecological procedures. In various embodiments, a method of generating a model for performing gynecologic procedures is described. In various embodiments, a method of determining a success rate of a minimally invasive procedure for a patient is described. In various embodiments, a method of enhancing a diagnosis of an ovarian tumor is described. In various embodiments, a method of providing a mixed reality guidance for performing gynecological procedures is described.
CCTA will be performed with one of the latest generation scanners. A stenosis \> 50% will be considered as significant from an anatomical point of view. For coronary stents, degree of intrastent restenosis will be evaluated by visual assessment of intraluminal contrast density. ISR \> 50% will be considered as significant from an anatomical point of view. For CABG, each graft will be visually evaluated and scored as patent, non-significant stenosis ≤ 50%, significant stenosis \> 50%, or occluded. For patients with positive CCTA results, additional stress CTP will be performed subsequently. If indicated, vasodilatation will be induced with i.v. adenosine injection or regadenoson. Static or dynamic CTP will be performed according to local practice and scanner technology available. For all patients with previous history of MI the presence of reversible ischemia will be obtained by the comparison between rest and stress perfusion.
Refractory status epilepticus is commonly defined as status epilepticus that fails to respond to two or more appropriately dosed intravenous anti-seizure medications including at least one non-benzodiazepine drug. Super-refractory status epilepticus (SRSE) is when status epilepticus continues for ≥24 h despite anesthetic treatment or recurs on an attempted wean of the anesthetic drugs. There is little evidence to guide the management of SRSE. Of late, unconventional therapies have been described in the literature regarding the management of SRSE, with ketamine leading the pack. Studies have noted ketamine's therapeutic efficacy up to 91% in SRSE cessation. Common side effects of ketamine include nausea, vomiting, headache, and hallucinations; but to our knowledge, ketamine has not been implicated in the pathogenesis of abdominal compartment syndrome. We describe a 74-year-old male who developed severe abdominal compartment syndrome in the setting of ketamine infusion for new-onset SRSE to increase awareness about this potential complication.
The trial was divided into three cycles, each lasting eight weeks. Participants performed a hybrid program of resistance training and endurance training of varying duration and intensity in each cycle. Each session lasted one hour, three times a week for 24 weeks.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine, namely to methods for producing wound healing drugs for external application. Producing a liposomal agent exhibiting wound healing action requires phospholipid extraction from Baikal seal liver; prepared mixed phospholipids and Baikal seal fat are dissolved in an organic solvent in the ratio 4:6 with the antioxidant -tocopherol added. A thin layer of lipids is dried in a rotary evaporator; a buffer solution is added; the mixture is agitated to prepared a homogeneous suspension. It is followed with ultrasound preparation of the lipid mixture with water cooling. The liposomal suspension mixed in the ratio 1:1 with pre-melted mixed polyethylene glycols 1000 and 6000 Da taken in the ratio 9:1. Further, the produced mixture is homogenised to a homogeneous mass. ^ EFFECT: use of the method allows producing the liposomal agent for external application exhibiting wound healing action. ^ 3 tbl, 3 dwg, 3 ex
Participants received a loading dose of dalotuzumab 15.0 mg/kg administered by IV infusion. Two weeks following completion of the loading dose, participants received a maintenance dose of dalotuzumab 5.0 mg/kg administered by IV infusion every two weeks for up to 18 months.
Stroke survivors face participation restrictions, yet little is known regarding how social support affects the association between an individual's abilities and participation. Through a Person-Environment-Occupation-Performance (PEOP) model lens, social support was examined as a potential mediator between ability and participation in cognitively and mobility-demanding activities for stroke survivors with aphasia (persons with aphasia [PWA]) and without aphasia (persons without aphasia [PWOA]). A cross-sectional design, including PWA (n = 50) and PWOA (n = 59) examined associations among person factors (physical impairment, cognition), an environmental factor (social support), and occupational participation through cognitively- and mobility-demanding activity subscales of the Activity Card Sort. Cognition was associated with participation in cognitively demanding activities for both groups, though social support was a mediator only for PWA. Physical impairment was associated with participation in mobility-demanding activities for PWOA, though social support did not mediate that relationship. Social support is key to PWA participating in cognitively demanding activities post-stroke.
The invention discloses a lateolabrax japonicus II-type interferon IFN-gamma rel and an antiviral composition and application of a receptor thereof. Wherein, the nucleotide sequence of the lateolabrax japonicus II type interferon IFN-gamma rel is shown as SEQ ID NO.1; the nucleotide sequence of the receptor CRFB6 is shown as SEQ ID NO. 3; the nucleotide sequence of the receptor CRFB13 is shown as SEQ ID NO. 5; the nucleotide sequence of receptor CRFB17 is shown in SEQ ID NO. 7. The antiviral composition comprises weever interferon IFN-gamma rel and weever II-type interferon receptors, wherein the weever II-type interferon receptors are one or the combination of more than two of CRFB6, CRFB13 and CRFB17. The application is the application of the antiviral composition containing the lateolabrax japonicus interferon IFN-gamma rel and the receptor thereof in the preparation of aquatic animal antiviral drugs. The antiviral composition can obviously reduce the copy number of the LBUSV virus in spleen, liver and head kidney tissues of the lateolabrax japonicus after infecting the young lateolabrax japonicus, and simultaneously can reduce the copy number of the LBUSV virus in the head kidney cells and arterial ball cell lines of the lateolabrax japonicus after infecting the lateolabrax japonicus, thereby not only enhancing the virus antagonistic capability of the lateolabrax japonicus, but also improving the virus antagonistic capability of other aquatic animals.
Sepsis, a common life-threatening clinical condition, continues to have high morbidity and mortality rates, despite advancements in management. In response, significant research efforts have been directed toward developing effective strategies. Within this scope, nanotechnology has emerged as a particularly promising field, attracting significant interest for its potential to enhance disease diagnosis and treatment. While several reviews have highlighted the use of nanoparticles in sepsis, comprehensive studies that summarize and analyze the hotspots and research trends are lacking. To identify and further promote the development of nanotechnology in sepsis, a bibliometric analysis was conducted on the relevant literature, assessing research trends and hotspots in the application of nanomaterials for sepsis. Next, a comprehensive review of the subjectively recognized research hotspots in sepsis, including nanotechnology-enhanced biosensors and nanoscale imaging for sepsis diagnostics, and nanoplatforms designed for antimicrobial, immunomodulatory, and detoxification strategies in sepsis therapy, is elucidated, while the potential side effects and toxicity risks of these nanomaterials were discussed. Particular attention is given to biomimetic nanoparticles, which mimic the biological functions of source cells like erythrocytes, immune cells, and platelets to evade immune responses and effectively deliver therapeutic agents, demonstrating substantial translational potential. Finally, current challenges and future perspectives of nanotechnology applications in sepsis with a view to maximizing their great potential in the research of translational medicine are also discussed.
OBJECTIVE: To investigate the clinical feasibility and effectiveness of the modified grafted tubularized incised plate urethroplasty (G-TIP), namely "glans G-TIP (GG-TIP) ", in treatment of hypospadias.
METHODS: A clinical data of 137 children with hypospadias qualified by the selection criteria between January 2021 and June 2023 was retrospectively analyzed. Among them, 75 children were treated with GG-TIP (GG-TIP group) and 62 with G-TIP (G-TIP group). There was no significant difference ( P>0.05) between the two groups in terms of age, hypospadias type, penile length, penile head width, penile head height, penile curvature, meatus-apex distance, urethral plate width, and distance from the distal endpoint of navicular groove to the dorsal or ventral midline point of the glans corona, and the difference between the two. The operation time, reconstructed urethral length, distance from meatus to ventral glans corona, postoperative complications, maximum urinary flow rate at 2 weeks after operation, and the hypospadias objective scoring evaluation (HOSE) score at 6 months after operation in the two groups were recorded and analyzed.
RESULTS: The operation time was significantly shorter in GG-TIP group than in G-TIP group ( P<0.05); but there was no significant difference ( P>0.05) between the two groups in terms of reconstructed urethral length and distance from meatus to ventral glans corona. All urinary meatus located at the tip of glans with vertical fissure shape. All children in the two groups were followed up 6-35 months (median, 26 months). During follow-up, there were 3 cases of urethral fistula, 2 cases of urethral stricture, and 1 case of glans separation in GG-TIP group, and 3, 3, and 1 cases in the G-TIP group, respectively. There was no significant difference in the incidence of complications between the two groups ( P>0.05). The maximum urinary flow rate at 2 weeks and the HOSE score at 6 months after operation were significantly higher in GG-TIP group than in G-TIP group ( P<0.05).
CONCLUSION: GG-TIP is safe and effective for repairing hypospadias in children. Compared with G-TIP, it has the advantages of relatively simple operation, shortened operation time, significant improvement in urinary flow rate, and better cosmetic results.
A sample of 250 participants will be recruited and randomly assigned to either the value affirmation (N=125) or reflective journaling (N=125) condition. Participants will complete baseline measures of physical symptoms, perceived stress, and other covariates. They will also be given an electronic pill bottle that will record whether they have daily opened and closed the bottle, signifying adherence to their prescribed medication regime. This pill bottle will sync to an online dashboard. Participants in both conditions will complete a brief essay online (or via paper and pencil for those who prefer or do not have internet access) every month for six months. Value affirmation condition essays will include prompts about important, core personal values. Reflective journaling essays will have prompts that do not include any core personal value content but ask participants, in part, to write about typical daily routines. Following the conclusion of the intervention, participants will report on their levels of perceived stress and physical symptoms. Six months following the post-intervention assessment, participants will again report their perceived stress levels and physical symptoms. A sample size of 250 has been selected for feasibility and because this sample size provides at least 80% power to detect differences for all three outcomes of interest.

A sub-study will be conducted on 80 of these participants who will complete their 3rd essay prompt in an fMRI scanner. In the scan session, participants will also complete a stress reactivity task. The sub-study will allow examination of the neural mechanism of value affirmation and reflective journaling to determine whether these neural mechanisms lead to enhanced medication adherence rates and reductions in stress and physical symptoms.
Derivs. are prepared by the action of peroxidase on tetracycline, 5-hydroxy-tetracycline or 6-demethyl-tetracycline, under aerobic conditions and in the presence of dihydroxyfumaric acid, at 15-37 degrees C, the 4-hydroxy cpds are produced, or tetracycline may be treated with a peracid, esp. m-chloroperbenzoic acid, to obtain secotetracycline derivs. or the action of H2O2 yields 4-hydroxy-4-dedimethyl-aminotetracyclin. The new derivs. have valuable antibiotic properties, and some may be used in cosmetic preparations for protection against sunlight.
An increasing body of evidence suggests that Group A beta-Hemolytic Streptococcal throat infections (GABHS) may trigger the onset of obsessive-compulsive disorder (OCD) and/or tic disorder in certain vulnerable children via an autoimmune process. In this subgroup of children with childhood-onset OCD and tic disorders, preliminary data suggest some children have a rapid response to amoxicillin. After only 24 to 48 hours of treatment, they have a dramatic reduction in OC symptoms and tics. To date, we have observed this phenomenon in at least 5 children, each of whom relapsed when the amoxicillin was stopped. These observations raise a number of questions, including whether or not amoxicillin has a direct central nervous system (CNS) effect or an indirect effect through perturbations of the immune system (e.g., cytokine shifts).

The purpose of this study is to determine if amoxicillin is an effective treatment for PANDAS, as well as examining possible mechanisms of this effect. We propose to do this with a 3-month double-blind placebo-controlled crossover trial of amoxicillin treatment with a randomized A-B-A-B design. Outcome measures will be blinded ratings of tic severity, standardized measures of psychopathology, and immunologic assays (such as type I and type II cytokine levels).
Metabolic syndrome (MetS), a constellation of metabolic abnormalities including central obesity, dyslipidemia, elevated blood pressure and hyperglycemia, is associated with the development of type 2 diabetes and CVD. It has become one of the major public health challenges in China due to rapidly nutrition transition and the nature of obesity epidemic. Treatment of MetS in China is very important for the prevention of the epidemic of its consequences (such as CVD and type 2 diabetes).

Compelling evidence from recent human studies has demonstrated that diet and lifestyle modifications are effective means in MetS management. Flaxseed is a complex food source containing high amounts of alpha-linolenic acid (ALA) - an omega-3 fatty acid - as well as fiber, lignan precursors and other substances that may have an impact on our health. Therefore, the aim of this study is to investigate the effect of flaxseed supplementation on the management of MetS in adult Chinese men and women in a randomized, controlled clinical trial. A total of 200 participants with MetS (defined by NCEP-ATPⅢ criteria) will be randomly assigned to a flaxseed-supplemented diet (30 grams/day) or an isocaloric control diet for 12 weeks. Effects of flaxseed supplementation will be evaluated by measuring metabolic profile (BMI, blood pressure, total cholesterol, triglyceride, LDL-C and HDL-C, fasting glucose and insulin, HbA1C), inflammatory markers (CRP and IL-6), markers of endothelial function (E-selectin, ICAM-1 and VCAM-1), and fatty acid profile.
Immune checkpoint inhibitors (ICIs) became a treatment option in most tumor types and improved survival in patients with cancer in the last decade. Older patients with cancer are underrepresented in the pivotal clinical trials with ICIs. Older patients with cancer often have significant comorbidities and geriatric syndromes like frailty, which can complicate cancer care and treatment decisions. Frailty is among the most prevalent geriatric syndromes in patients with cancer and could lead to inferior survival and a higher risk of complications in patients treated with chemotherapy. However, the effect of frailty on the efficacy and safety of ICIs is understudied. This review focuses on the available evidence regarding the association between frailty and ICI efficacy and safety. Although the survival benefits of ICIs have generally been shown to be independent of age, the available real-world data has generally suggested higher rates of immune-related adverse events (irAEs) and treatment discontinuation in older patients. While international organizations recommend conducting a comprehensive geriatric assessment CGA to assess and address frailty before the start of anti-cancer therapies, an Eastern Cooperative Oncology Group (ECOG) performance status of 2 or higher is frequently used in clinical practice as synonymous with frailty, albeit with significant limitations. The available data has generally demonstrated diminished ICI efficacy in patients with an ECOG 2 or higher compared to patients with better performance status, while the incidence of high-grade irAEs were similar. Whilst evidence regarding outcomes with ICI in older patients and in those with sub-optimal performance status is growing, there is very limited data specifically evaluating the role of frailty with ICIs. These studies found a shortened overall survival, yet no evidence of a lower response rate to ICIs. These patients experienced more AEs, but they did not necessarily have a higher incidence of irAEs.
Symptoms and response to rest has been reported to have differences between male and female patients. Age under 14 years was considered an exclusion due to immaturity in insight and reporting. Thus, young adult ages and older were included and observations between gender reporting was noted.
Irregular and/or rapid beating of the heart called heart palpitations can occur in individuals without heart disease and the reasons for their palpitations are unknown. Together with heart palpitations silent arrhythmia may be present that could lead to serious complications (eg. stroke). In others, palpitations result from heart rhythm disturbances, sometimes life threatening. Standard diagnostic methods such as 24 hours Holter electrocardiogram (ECG) monitoring or Event Holter do not guarantee early diagnosis of the arrhythmia. Prolonged heart rhythm recording and analysis using an automatic full disclosure telemetric device can increase probability of arrhythmia diagnosis and early administration of applicable treatment. Study patients will be diagnosed using standard Holter ECG monitoring, Event Holter or 30 days telemetric ECG monitoring. Efficacy of telemetric monitoring in diagnosis of cardiac arrhythmia will be assessed in comparison with the standard Holter monitoring and Event Holter