anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a combined medicine for treating chronic myeloid leukaemia. The medicine comprises imatinib and atebrine in a mass concentration ratio of 1:8-1:12. The invention further provides an application of atebrine in preparing medicines for treating chronic granulocytic leukemia. According to the invention, atebrine can reduce Bcr/abl in a CML cell K562 and drug-resistant cells K562-R and 32D-Bcr/ablT3151 cell as well as the phosphorylated protein level so as to reduce the Bcr/abl protein in the leukemia cell of the CML patient. The combination of atebrine and imatinib synergically leads a lethal effect to the CML cell by a lower dosage and is also effective to the drug-resistant cell of the CML while has no remarkable toxic and side effects to a single peripheral blood mononuclear cell of an average person. Atebrine and imatinib are mature medicines which are clinically applied and have the advantages of convenience in delivery, low cost and the like, thereby providing a novel more effective treatment scheme for clinically treating CML.
In the OncoKB(Precision Oncology Knowledge Base) database, the gene alteration has a variant of clinical evidence in this tumor or other tumor types and is considered to be an interventional variant. Cohort-A may include different observation subgroups. For example, substudy-A1: monotherapy/combination therapy for patients with A1-relative. Substudy-Ax: monotherapy/combination therapy for patients with Ax-relative.
Intrauterine growth restriction (IUGR) affects a large proportion of infants, particularly in underdeveloped countries. Among the main causes of IUGR, maternal endocrine-metabolic dysfunction is highlighted, either due to its high incidence or due to the severity of the immediate and mediated changes that these dysfunctions cause in the fetus and the mother. Although the effects of endocrine and metabolic disorders have been widely researched, there are still no reviews that bring together and summarize the effects of these conditions on bone development in cases of IUGR. Therefore, the present literature review was conducted with the aim of discussing bone changes observed in fetuses with IUGR caused by maternal endocrine-metabolic dysfunction. The main endocrine dysfunctions that occur with IUGR include maternal hyperthyroidism, hypothyroidism, and hypoparathyroidism. Diabetes mellitus, hypertensive disorders, and obesity are the most important maternal metabolic dysfunctions that compromise fetal growth. The bone changes reported in the fetus are, for the most part, due to damage to cell proliferation and differentiation, as well as failures in the synthesis and mineralization of the extracellular matrix, which results in shortening and fragility of the bones. Some maternal dysfunctions, such as hyperthyroidism, have been widely studied, whereas conditions such as hypoparathyroidism and gestational hypertensive disorders require further study regarding the mechanisms underlying the development of bone changes. Similarly, there is a gap in the literature regarding changes related to intramembranous ossification, as most published articles only describe changes in endochondral bone formation associated with IUGR. Furthermore, there is a need for more research aimed at elucidating the late postnatal changes that occur in the skeletons of individuals affected by IUGR and their possible relationships with adult diseases, such as osteoarthritis and osteoporosis.
PURPOSE: Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance.
CASE PRESENTATION: On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain.
CONCLUSION: Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.
Total knee replacement patients with preoperative knee stiffness (defined as flexion \< 100 degrees or extension lag \> 10 degrees) receive 3 doses of 100mg intravenous hydrocortisone every 8 hours. The first dose is given in the holding area approximately 2 hours prior to first incision.
Hypnosis has sometimes been described as an "altered state of consciousness," but what is "unaltered" consciousness? We approach the issue by first exploring the sense of free will, because it can be lost during hypnosis. However, the argument is developed that free will is an illusion, so should not be present in the waking state. Thus, in a sense, hypnosis is a more accurate state of consciousness. The sense of free will is shown to result from an experience of agency, which is often missing in hypnosis. We consider how hypnotic, illusory perceptions are developed, and plausible processes are discussed, but none throws clear light upon what the philosopher David Chalmers called the "hard problem" of consciousness. The paper concludes with a brief evaluation of the possibility that phenomenal consciousness is associated with feedback loops, which transform the simple registering of stimuli into experiences of which we are aware.
Rapid drug clearance and off-target effects of therapeutic drugs can induce low bioavailability and systemic side effects and gravely restrict the therapeutic effects of inflammatory bowel diseases (IBDs). Here, we propose an amplifying targeting strategy based on orally administered gallium (Ga)-based liquid metal (LM) nano-agents to efficiently eliminate reactive oxygen and nitrogen species (RONS) and modulate the dysregulated microbiome for remission of IBDs. Taking advantage of the favorable adhesive activity and coordination ability of polyphenol structure, epigallocatechin gallate (EGCG) is applied to encapsulate LM to construct the formulations (LM-EGCG). After adhering to the inflamed tissue, EGCG not only eliminates RONS but also captures the dissociated Ga to form EGCG-Ga complexes for enhancive accumulation. The detained composites protect the intestinal barrier and modulate gut microbiota for restoring the disordered enteral microenvironment, thereby relieving IBDs. Unexpectedly, LM-EGCG markedly decreases the Escherichia_Shigella populations while augmenting the abundance of Akkermansia and Bifidobacterium, resulting in favorable therapeutic effects against the dextran sulfate sodium-induced colitis.
Cervical spine manipulation is a known risk factor for vertebral artery dissection. In this report, we present a case of fatal vertebral artery dissection that occurred as the result of self-manipulation of the cervical spine. The decedent was a 40-year-old man with no significant past medical history. He was observed to "crack his neck" while at work. Soon after, he began experiencing neck pain, then developed strokelike symptoms and became unresponsive. He was transported to a local medical center, where imaging showed bilateral vertebral artery dissection. His neurological status continued to decline, and brain death was pronounced several days later. An autopsy examination showed evidence of cerebellar and brainstem infarcts, herniation, and diffuse hypoxic-ischemic injury. A posterior neck dissection was performed to expose the vertebral arteries, which showed grossly visible hemorrhage and dilation. There was no evidence of traumatic injury to the bone or soft tissue of the head or neck. Bilateral dissection tracts were readily appreciated on microscopic examination. Death was attributed to self-manipulation of the neck, which in turn led to bilateral vertebral artery dissection, cerebellar and brainstem infarcts, herniation, hypoxic-ischemic injury, and ultimately brain death.
Clinical studies have been conducted and specific dosage formulations developed using polymeric microparticles having incorporated therein perfluorocarbon gases that provide significantly enhanced images of long duration. The dosage formulation includes microparticles formed of a biocompatible polymer, preferably including a lipid incorporated therein, and containing a perfluorocarbon that is a gas at body temperature. The microparticles are provided to a patient in an amount effective to enhance ultrasound imaging in the ventricular chambers for more than 5 minutes or in the mycocardium for more than a minute, in a dose ranging from 0.025 to 8.0 mg microparticles/kg body weight. Preferably the dose ranges from 0.05 to 4.0 mg microparticles/kg body weight. The dosage formulation typically is provided in a vial. A typical formulation is in the form of a dry powder that is reconstituted with sterile water prior to use by adding the water to the vial or syringe of the dry powder and shaking to yield an isosmotic or isotonic suspension of microparticles.
BACKGROUND: Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1), the catalytic subunit of collagen prolyl 4-hydroxylase, is a glycolysis-related gene in cancers. However, its role in glycolysis-induced angiogenesis remains unclear.
METHODS: P4HA1 expression was modulated using adenoviruses. Endothelial angiogenesis was evaluated through 5-ethynyl-2'-deoxyuridine incorporation, transwell migration, and tube formation assays in vitro. In vivo experiments measured blood flow and capillary density in the hindlimb ischemia (HLI) model. Glycolytic stress assays, glucose uptake, lactate production, and quantitative reverse transcription-polymerase chain reaction (RT-PCR) were employed to assess glycolytic capacity. Transcriptome sequencing, validated by western blotting and RT-PCR, was utilized to determine underlying mechanisms.
RESULTS: P4HA1 was upregulated in endothelial cells under hypoxia and in the HLI model. P4HA1 overexpression promoted angiogenesis in vitro and in vivo, while its knockdown had the opposite effect. P4HA1 overexpression reduced cellular α-ketoglutarate (α-KG) levels by consuming α-KG during collagen hydroxylation. Downregulation of α-KG reduced the protein level of a DNA dioxygenase, ten-eleven translocation 2 (TET2), and its recruitment to the fructose-1,6-biphosphatase (FBP1) promoter, resulting in decreased FBP1 expression. The decrease in FBP1 enhanced glycolytic metabolism, thereby promoting endothelial angiogenesis.
CONCLUSIONS: Hypoxia-induced endothelial P4HA1 overexpression enhanced angiogenesis by promoting glycolytic metabolism reprogramming through the P4HA1/α-KG/TET2/FBP1 pathway. The study's findings underscore the significance of P4HA1 in post-ischemic angiogenesis, suggesting its therapeutic potential for post-ischemic tissue repair.
The invention provides a traditional Chinese medicine composition for treating a polycystic ovarian syndrome. Roasted herba epimedii and rhizoma acori graminei serve as monarch drugs, kidney tonifying and phlegm reducing are regarded as equally important, and elimination and supplementary are simultaneously implemented. Amethysts, cornu cervi degelatinatum, semen cuscutae, rhizoma pinelliae and fructus aurantii immaturus serve as ministerial drugs, amethysts, cornu cervi degelatinatum and semen cuscutae complement one another to achieve mutual promotion with roasted herba epimedii for use, and therefore the effect of tonifying the kidney to strengthen yang of roasted herba epimedii is improved; rhizoma pinelliae and fructus aurantii immaturus complement each other to achieve mutual promotion with rhizoma acori graminei for use, and therefore the effects of reducing phlegm and removing dampness of rhizoma acori graminei are enhanced. Fructus trichosanthis, bile arisaema, rhizoma atractylodis, prepared rhizoma cyperi, radix salvia miltiorrhiza and fructus leonuri jointly serve as adjuvant drugs, fructus trichosanthis, bile arisaema and rhizoma atractylodis have the effects of clearing heat and reducing phlegm, and prepared rhizoma cyperi, radix salvia miltiorrhiza and fructus leonuri have the effect of promoting blood circulation for regulating menstruation. Licorice roots are used for moderating the property of all the herbs and serve as a guide drug. All the drugs jointly achieve the effects of tonifying the kidney, reducing the phlegm and promoting blood circulation to promote menstruation. The traditional Chinese medicine composition for treating the polycystic ovarian syndrome is exact in treatment effect.
On day one, patients will receive the first of two doses of the Shingrix vaccine administered as an injection into the muscle in their upper arm. The second dose of vaccine will be administered as an injection to their upper arm approximately 2 months after the first dose.
One in 4000 full-term infants develops arterial ischemic stroke at the time of birth.5 These children are commonly called an infantile stroke, infantile hemiplegia, perinatal stroke, and congenital hemiplegic cerebral palsy. Epileptic seizures are common in 24-45 % of children suffering from an infantile stroke within a month.6 Noninvasive brain stimulation (NIBS) is the novel method of delivering therapeutic currents to the brain for the purpose of diagnosis and treatment 7. There is an exponential increase in researches on the effect of NIBS on cognitive deficits. The NIBS has proven to cause neural modulation at the cortical level8. The effect of stimulation is either increased or decreased in neuronal activity, depending on the anodal and cathodal stimulation, firing rate, and period of the activation or inhibition910. There are two types of NIBS techniques safely practiced among humans, these are, Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tCDS)11. tCMS uses a weak magnetic field that transforms into beneficial currents into the brain for diagnostic (Single-pulse tCMS) or treatment purposes (repetitive tCMS). The inhibitory or excitatory cortical effects are achieved by decreasing or increasing the frequency and duration of tCMS 12. tCDS involves the use of weak direct or alternating current applied on the scalp via electrodes for the purpose of neural modulation13. The most popular form of tCDS device is a battery-operated stimulator capable of producing direct current ranging from 0.5-2.0 mA14. Neural modulation is achieved by altering the resting membrane potential. The anode causes increased excitability due to its depolarizing effect whereas the cathode electrode causes inhibition due to the hyperpolarization effect14.

Virtual reality (KVR) is the use of a computer interface involving upper limb activity in pediatric rehabilitation. VR creates an artificial environment, presented to the user through appropriate sensory stimulations. Participants use the motion sensor mounted on the paretic hand to interact with the virtual environment. The participants will receive visual and auditory feedback. The purpose of the study is to evaluate the combined effect of virtual reality activities and tDCS on upper limb activity in children with hemiparesis.
PROBLEM TO BE SOLVED: To certainly eliminate dirt on surfaces of both a quick-tightening cylinder and a tightening pallet together with a bore emulsion getting into between them, by providing a spouting device making use of flow-acceleration of compressed air caused by reducing a cross section when air for cleaning is discharged. SOLUTION: A longitudinal hole leads from a compressed air connection part 11 to a lateral passage 12 for feeding a compressed air to both a longitudinal hole 13 and a nozzle 52. This distribution of supply of the compressed air can adjust the compressed air in a compressed air feeding system through variable adjustment of an effective cross section of the nozzle 52. When a quick- tightening cylinder 1 is released, a retracting nipple is moved upward so that an opening of a lateral hole is opened. Thereby, the compressed air from the lateral hole flows out, while an air pressure in the compressed air feeding system drastically drops. That is, just after a piston 5 moves the retracting nipple upward, a spouting hole 19 is opened so that the compressed air spouts out to perform cleaning.
The invention relates to a novel antioxidant and a preparation method thereof. The structural formula of the antioxidant is shown in img file = 'dest _ path _ image 001. TIF 'wi = '152 'he = '86 ', wherein R is an alkyl group CnH2n +1, and n is 0 to 22. According to the technical scheme of the invention, an obtained product is strong in antioxidant activity at normal temperatures and high temperatures, better in lipid solubility and relatively good in water solubility. The product can be used as an antioxidant for fatty foods and can enhance the absorbability of drugs in a human body. The product is easy in salification and has a higher boiling point. At a high temperature, the product is not easy to volatilize, so that the requirements of fatty foods on high-temperature antioxidants can be met. The product comprises carboxyl groups and phenolic hydroxyl groups, so that the coupling between molecules is easily formed in a high-temperature environment to generate compounds larger in molecular weight and higher in boiling point. The product is difficult to volatilize at a high temperature, so that the antioxidant activity of the product can be better realized in a high-temperature frying environment.
Beta blockers are used as topical ophthalmic preparation for reducing Intra Ocular Pressure. B-blocker used for this purpose include timolol, levobunolol, carteolol, metipranalol. They reduce the aqueous production and thereby reduce I.O.P. They are commonly used as drops. Efficacy of topical B-blockers is dependent on concentration of drug in formulation. However, increasing the concentration of drug beyond approved dosage forms does not increase the efficacy significantly e.g. Timolol 0.5% has identical pressure lowering capacity as 1% Timolol. The attempts to improve pressure reduction efficiency of B-blockers has not met with success so far. The sustained release formulation of Timolol (Timolol XE) has resulted in amount of drug to achieve same therapeutic effect. However, none of the formulation has improved efficacy of drug for reducing I.O.P. The present invention relates to the process of manufacturing such formulation of B-blocker which improves its I.O.P lowering effect. The formulation so prepared is non-irritating and well tolerated. The process of manufacturing new formulation with improved efficacy involves use of carboprolol and preservative. The timolol 0.5% gel formulated using process was evaluated in normal as well as glaucomatous eyes. The reduction in I.O.P. is found to be approx. 15% more than found with drops in normal individuals. Similar findings are also observed in glaucomatous eyes.
The invention relates to the medicine, namely to psychiatry and narcology and may be used for treating drug and alcohol addicts. The aim of the invention consisted in developing the implant against narcotic and alcohol addiction. The combination of the components in the implant developed provides for the maximal effect with minimum of complications. The implant comprises Naltrexone hydrochloride and polyacrylamide gel. The method for manufacture of the implant is also described. The implant against narcotic and alcohol addiction provides for increasing the duration of the remission with the absence of the serious adverse reactions.
A walking training apparatus is a motion support system that includes a walking assistance apparatus as an assistance apparatus, a selected assistance level setting unit, a load data acquisition unit, an angle sensor as a displacement sensor, and an overall control unit as a control unit. The assistance apparatus assists a motion of a joint performed by a user. The assistance level setting unit sets an assistance level that is a level of a force exerted by the assistance apparatus. The load data acquisition unit acquires load data related to a load of the assistance apparatus. The displacement sensor detects a displacement of the joint. The control unit determines a recommended assistance level, which is an assistance level to be recommended, based on the assistance level, the load data, and an output of the displacement sensor, and outputs information about the determined recommended assistance level.
NEW MATERIAL:The pyrrolidine derivative of formula I (R<1> is piperidino or phenylamine substituted with carboxy or protected carboxy; R<2> and R<3> are aryl which may have 1-3 proper substituents) and its salt. EXAMPLE:(2S,4S)-1-tert-butoxycarbonyl-4-methylsulfonyloxy-2- methoxycarbonylpyrrolidine. USE:It has thromboxane A2 (TXA2) antagonistic action and is useful as a drug. Effective in remedying thrombosis, asthma, nephritis, etc. PREPARATION:The compound of formula I can be produced e.g., according to the reaction formula by reacting a compound of formula II with a novel compound of formula III (X is halogen). The compound of formula III can be synthesized from a compound of formula IV.
The invention discloses a clopidogrel hydrogen sulfate tablet and a preparation method thereof. The tablet comprises the following components in parts by weight of: 39.44 parts of clopidogrel hydrogen sulfate, 31.53 parts of lactose, 15 parts of pregelatinized starch, 10 parts of microcrystalline cellulose, 2.7 parts of polyethylene glycol 6000, 1.33 parts of hydrogenated castor oil and 3 parts of lagging cover thin film. According to the invention, the pregelatinized starch and the polyethylene glycol 6000 are added by an inner adding method and an outer adding method in the process of pelletizing, so that the sticking of drug in the process of tabletting can be reduced. Furthermore, after the dry granulation is adopted, the problem that the drug is easy to stick in the process of tabletting can be further solved. The clopidogrel hydrogen sulfate tablet prepared by the invention is short in disintegration time, and quick in dissolving-out speed, and the hardness of the tablet can reach 70-80N. The invention is simple to operate, and easy to industrially popularize.
PURPOSE: To prevent and cure ventricular arrhythmia by administering a muscarinic agonist. CONSTITUTION: Ventricular arrhythmia of mammals are prevented or cured by administering a muscarinic agonist, e.g. oxotremorine, methacholine, bethanechol, pilocarpine or pharmaceutically allowable salts of them. The muscarinic agonist is especially suitable for preventing malignant ventricular arrhythmia induced by ischemic episode, increase of sympathetic activity or a combination of the both factors and effective for curing ventricular arrhythmia induced by myocardial infarction at its acute stage. If needed, usual curing agents for arrhythmia, e.g. flecainide, encainide, procainamide, lidocaine, etc., can be used at the same time.