anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Gluteal tendinopathy, also known as greater trochanteric pain syndrome, interferes with physical function and sleep, and is characterized by pain and tenderness over the greater trochanter.Clinical risk factors for the development of this condition include advanced age, female gender, back pain, overweight / obesity, poor abductor hip function, altered gait parameters, and psychological distress. The Victorian Institute of Sports Assessment for Gluteal tendinopathy (VISA-G) Questionnaire has recently designed as a patient-reported condition-specific outcome measurement tool to assess disability due to tendinopathy. VISA-G is scored between 0 and 100 (a higher score is expected) and consists of eight items covering three main areas (pain, function, and current activity level). Visual analog score for pain (0-10), the effect of pain on weight-bearing activities (0-30), and difficulty and / or function-related stairs use, including lying on the symptomatic side (0-10), climbing ramps (0-10), standing up without sitting (0-10), home or garden work (0-10) and regular exercise (0-10), physical activity and sports participation (0-10) are evaluated. The study is planned with 40 individuals with gluteal tendinopathy. After questioning the sociodemographic characteristics of the individuals, the patients will be asked to fill in VISA-G, Short Form-36, International Physical Activity Questionnaire, Numeric Rating Scale, Oswestry Disability Index, Oxford Hip Score and modified Harris Hip Score.Test-retest will be re-applied to those of the same individuals who can be reached after 1 week. The results will be analyzed using the SPSS version 22.0 computer package program.
The present invention discloses sterilization gel, a preparation method thereof and application thereof. The sterilization gel comprises 0.0001 to 0.01 wt% of glycyl-glycine endopeptidase, 0.01 to 1 wt% of lysozyme, 1 to 20 wt% of thickening agent, 0.1 to 15 wt% of emollient and water as the balance. The washing-free sterilization cleanser for hands has very ideal sterilization effect on escherichia coli, staphylococcus aureus and pyocyaneum bacteria for bactericidal experiments in vitro. The killing rate exceeds more than 99%. The test result for stimulating SD rat vagina mucous membranes indicates that the sterilization gel has no stimulation. After different samples are sterilized for 6 hours, the detection indicates that the bacterial killing rate reaches more than 90%. Thus, the sterilization gel has very good effect in the aspect of sterilizing hands. The sterilization gel can be used for cleaning and sterilizing the skin mucous membranes of hands. The sterilization gel can keep skin nourishing and moistening and prevent the infection of bacteria and fungi.
Depression is a significant factor contributing to postoperative occurrences, and patients diagnosed with depression have a higher risk for postoperative complications. Studies on cardiovascular surgery extensively addresses this concern. Several studies report that people who undergo coronary artery bypass graft surgery have a 20% chance of developing postoperative depression. A retrospective analysis of medical records spanning 21 years, involving 817 patients, revealed that approximately 40% of individuals undergoing coronary artery bypass grafting (CABG) were at risk of perioperative depression. Patients endure prolonged suffering from illness because each attempt with standard antidepressants requires several weeks to be effective. In addition, multi-drug combination adjuvants or combination medication therapy may alleviate symptoms for some individuals, but they also increase the risk of side effects. Conventional antidepressants primarily modulate the monoamine system, whereas different therapies target the serotonin, norepinephrine, and dopamine systems. Esketamine is a fast-acting antidepressant with high efficacy. Esketamine is the S-enantiomer of ketamine, a derivative of phencyclidine developed in 1956. Esketamine exerts its effect by targeting the glutaminergic system the glutaminergic system. In this paper, we discuss the current depression treatment strategies with a focus on the pharmacology and mechanism of action of esketamine. In addition, studies reporting use of esketamine to treat perioperative depressive symptoms are reviwed, and the potential future applications of the drug are presented.
Rational use of carbapenem is closely associated with the clinical outcome of patients with infections. Serum concentration of carbapenem varies from different populations. The objective of this study is to describe the clinical outcome of patients with infection treated by carbapenem in China, regarding diagnosis, treatment and follow-up. It is a single-center, retrospective, descriptive study. Inclusion criteria are an age ≥ 18, diagnosed as bacteria infection and serum concentration must be determined during therapy. Data concerning clinical presentation, biological samples, treatment and follow-up will be assessed. A descriptive analysis will be performed.
The scarcity of annotated data is a common issue in the realm of heartbeat classification based on deep learning. Transfer learning (TL) has emerged as an effective strategy for addressing this issue. However, current TL techniques in this realm overlook the probability distribution differences between the source domain (SD) and target domain (TD) databases. The motivation of this paper is to address the challenge of labeled data scarcity at the model level while exploring an effective method to eliminate domain discrepancy between SD and TD databases, especially when SD and TD are derived from inconsistent tasks. This study proposes a multi-module heartbeat classification algorithm. Initially, unsupervised feature extractors are designed to extract rich features from unlabeled SD and TD data. Subsequently, a novel adaptive transfer method is proposed to effectively eliminate domain discrepancy between features of SD for pre-training (PTF-SD) and features of TD for fine-tuning (FTF-TD). Finally, the adapted PTF-SD is employed to pre-train a designed classifier, and FTF-TD is used for classifier fine-tuning, with the objective of evaluating the algorithm's performance on the TD task. In our experiments, MNIST-DB serves as the SD database for handwritten digit image classification task, MIT-DB as the TD database for heartbeat classification task. The overall accuracy of classifying heartbeats into normal heartbeats, supraventricular ectopic beats (SVEBs), and ventricular ectopic beats (VEBs) reaches 96.7 %. Specifically, the sensitivity (Sen), positive predictive value (PPV), and F1 score for SVEBs are 0.802, 0.701, and 0.748, respectively. For VEBs, Sen, PPV, and F1 score are 0.976, 0.840, and 0.903, respectively. The results indicate that the proposed multi-module algorithm effectively addresses the challenge labeled data scarcity in heartbeat classification through unsupervised learning and adaptive feature transfer methods.
The invention provides a body-building nutritional and health-care capsule which is prepared from the following raw materials in percentage by weight: a burdock extract, a Morinda officinalis extract, milk mineral salt, vitamin E, Polygonum multiflorum and the of Chinese wolfberry. The preparation method comprises the following steps: preparing extracts of the raw materials according to a conventional process; drying and crushing to 200-300-mesh fine powder; then weighing the raw materials in percentage by weight and uniformly stirring; packaging in capsules to prepare the capsule preparations. Each capsule contains 0.25-0.5g. The capsule is characterized in that the raw materials are officinal and edible Chinese herbal medicines and are sufficient in supply and easy to obtain, and free from toxic and side effects for long-term use. Middle aged and elderly people taking the capsule frequently can immediate supplement protein, calcium and vitamin E required by human body everyday. Chinese herb extracts of burdock, morinda officinalis, Polygonum multiflorum and the of Chinese wolfberry can provide sufficient active components for human body and have the functions of dispelling wind and heat, opening the inhibited lung-energy and promoting eruption, detoxifying and relieving sore-throat, reinforcing kidney to strengthen yang, dispelling wind and eliminating dampness, strengthening tendons and bones and preventing aging, so that the capsule is a conveniently-taken health-care food for the middle aged and elderly people.
Ritonavir (RTV), which is used in combination with nilmatrelvir (NMV) to treat coronavirus disease 2019 (COVID-19), inhibits cytochrome P450 (CYP) 3A, thereby increasing blood tacrolimus (TAC) levels through a drug-drug interaction (DDI). We experienced a case in which a DDI between the two drugs led to markedly increased blood TAC levels, resulting in vasospastic angina (VSA) and acute kidney injury (AKI). Rifampicin (RFP) was administered to induce CYP3A and promote TAC metabolism. A 60-year-old man with dermatomyositis who was taking 3 mg/day TAC contracted COVID-19. The patient started oral NMV/RTV therapy, and he was admitted to the hospital after 4 days because of chest pain and AKI. On day 5, his blood TAC level increased markedly to 119.8 ng/mL. RFP 600 mg was administered once daily for 3 days, and his blood TAC level decreased to the therapeutic range of 9.6 ng/mL on day 9, leading to AKI improvement. Transient complete atrioventricular block and nonsustained ventricular tachycardia were present during chest pain. In the coronary spasm provocation test, complete occlusion was observed in the right coronary artery, leading to a diagnosis of VSA. VSA and AKI are possible side effects of high blood TAC levels caused by DDI, and attention should be paid to cardiovascular side effects such as VSA and AKI associated with increased blood levels of TAC when it is used together with NMV/RTV. When blood levels of TAC increase, oral RFP can rapidly decrease TAC blood levels and potentially reduce its toxicity.
BACKGROUND: Transcranial Doppler (TCD) is a technique to assess blood flow velocity in the cerebral arteries. TCD is frequently used to monitor aneurysmal subarachnoid hemorrhage (aSAH) patients. This study compares TCD-criteria for vasospasm and its association with Delayed Cerebral Ischemia (DCI). An overall score based on flow velocities of various intracranial arteries was developed and evaluated.
METHODS: A retrospective diagnostic accuracy study was conducted between 1998 and 2017 with 621 patients included. Mean flow velocity (MFV) of the cerebral artery was measured between 2-5 days and between 6-9 days after ictus. Cutoff values from the literature, new cutoff values, and a new composite score (Combined Severity Score) were used to predict DCI. Sensitivity, specificity, and area under the curve (AUC) were determined, and logistic regression analysis was performed.
RESULTS: The Combined Severity Score showed an AUC 0.64 (95%CI 0.56-.71) at days 2-5, with sensitivity 0.53 and specificity 0.74. The Combined Severity Score had an adjusted Odds Ratio of 3.41 (95CI 1.86-6.32) for DCI. MCA-measurements yielded the highest AUC to detect DCI at day 2-5: AUC 0.65 (95%CI 0.58-0.73). Optimal cutoff MFV of 83 cm/s for MCA resulted in sensitivity 0.73 and specificity 0.50 at days 2-5.
CONCLUSION: TCD-monitoring of aSAH patients may be a valuable strategy for DCI risk stratification. Lower cutoff values can be used in the early phase after the ictus (day 2-5) than are commonly used now. The Combined Severity Score incorporating all major cerebral arteries may provide a meaningful contribution to interpreting TCD measurements.
Consenting adult patients with active pulmonary MDR-TB in the study hospital in China (n=50), will be included in the study. Detailed demographic background information as well as baseline clinical characteristics will be collected. Sputum samples for culture and Time to culture positivity (TTP) will be collected at inclusion and at day 2, 7 and week 2, 4, 8 and 12 weeks after start of treatment. MIC-determination of Mycobacterium tuberculosis for all drugs included in the patient's treatment, will be performed mainly using Sensititre TREK kit, complemented with BACTEC 960 MGIT when necessary. After two weeks of TB-treatment, plasma drug concentrations of all the drugs used will be collected. Multiple blood samples (0, 1, 2, 4, 6, 8 and 10 h after drug intake) will be collected in order to accurately calculate the free area under the time-versus concentration curve (fAUC) and maximum concentrations (fCmax). The exposure variables are the fAUC and the fCmax and their ratio with the MIC for the bacteria of the different drugs. Furthermore, blood sampling to assess stability of drug concentrations will be performed at week 8 and week 12 (0, 4 and 6 h post-dose). In order to evaluate if low ratios of fAUC/MIC and fCmax/MIC are associated with poor clinical outcome, clinical parameters as well as sputum culture conversion, time to culture positivity (TTP), inflammatory markers and radiological imaging will be followed up during the first three months of treatment. After treatment completion, the WHO criteria for defining treatment outcome will be applied.

Furthermore, a method of simultaneous determination using LC-MS/MS of the second-line drugs used, will be developed and compared with the use of Dried Blood Spot assay (DBS). DBS has the advantage of enabling drug concentration analysis even in remote areas, since transportation of the filter papers is easy.
A fuzzy logic approach to the problem of distinguishing cerebrospinal fluid, gray and white matter pixels in magnetic resonance images of the brain. An unsupervised fuzzy clustering procedure based on a variant of the fuzzy c-means algorithm computes automatically, with virtually no operator intervention, the percentage area of each of these three compartments in each image. Each volume element represented in the image can belong to all compartments in varying degrees. The procedure requires input of the number of different compartments in the image, as well as a parameter which determines the amount of overlap of compartment boundaries. Preliminary data processing involves noise removal from images by highpass filtering. The final solution is substantially independent of required initial estimates of the gray scale values that are most representative of the white, gray and cerebrospinal fluid compartments in the image. The method is useful in the diagnosis of hydrocephalus.
This study is a safety, feasibility, and efficacy trial that was conducted on eligible GvHD patients with the diagnosis of expert doctors after obtaining permission from the respected ethics committee and registering the trial at the Iranian Trial Registration Center. During the phone call, while stating the title and objectives of the study, the entry and exclusion criteria were checked. If they are eligible, they were asked to attend the Ghazi Hospital if they wish to participate in the study. In the face-to-face meeting, the objectives of the research were fully explained and the study criteria were re-examined. The written informed consent was obtained and questionnaires fulfilled three times which include personal-social characteristics, medical characteristics, appetite questionnaire, 24-hour food record (Food record), and family members. At the beginning of the study, 50 cc of blood was used to collect serum and to culture and condition mesenchymal stem cells. 200 men with GvHD were randomly assigned using random block method using blocks of 4 and 6 and RAS (Random Allocation Software) and allocation ratio 1:1 to two groups receiving intravenous secretome with The first protocol (30 people) and receiving the mesenchymal stem cells secretome of the second protocol (30 people) were allocated and they received the skin spray for 1 year. Participants in the first protocol group at the beginning of the study, day 3, end of the week, the end of the second week, and the end of the month 5 times and in the second protocol group at the beginning of the study, skin spray were done. The secretome of both groups was the same.
This is a multicenter (when more than one hospital or medical school team work on a medical research study), double-blind (neither the participant nor the physician know the study medication drug name), randomized (study drug assigned by chance), placebo- and active-controlled, parallel-group (a clinical trial comparing the response in two or more groups of participants receiving different treatments), dose-response study in participants with schizophrenia. The total study duration will not exceed 16 weeks for each participant and will include following visits: screening, baseline, Week 1, 2, 3, 4, 5, 6, 7, 8, 9, 11 and 13 (end of treatment or early withdrawal), and a post-study safety visit (1 week after final dose of study drug). All participants will be hospitalized during the first 2 weeks of treatment for detailed follow-up of safety and disease status. Following a screening period, participants will be randomly assigned to one of 5 treatment groups to receive oral doses of JNJ-37822681 (10, 20 or 30 milligram \[mg\] twice a day) for 12 weeks, olanzapine 15 mg daily for 12 weeks, or placebo for 6 weeks followed by olanzapine 15 mg daily for the remaining 6 weeks. Olanzapine will be initiated at 10 mg daily for 1 week and then increased to 15 mg daily for the remainder of the treatment period. Efficacy will primarily be evaluated by Positive And Negative Syndrome Scale (PANSS). Participants' safety will also be monitored at each visit.
Participants in this arm will be given a 1,000mg dose of intravenous tranexamic acid via saline infusion 15 minutes prior to the completion of surgery. They will keep a bleeding diary with daily entries each day until their first routine scheduled postoperative follow-up clinic visit one week after surgery.
PURPOSE:To provide a cleanser composition having excellent touch during or after used without damaging the cleansing function thereof, by compounding an acidic heteropolysaccharides originated from the genus Pollanthes L. and a surfactant. CONSTITUTION:Acidic heteropolysaccharides containing as the constituting components thereof arabinose, mannose, galactose, xylose and glucuronic acid and obtained by the tissue culture method of a plant belonging to the genus Pollanthes L. such as Pollanthes tuberosa L. and a surfactant are mixed with conventional other components to provide the objective composition. The composition can be prepared into shampoos, cleansing foams, body shampoos, solid soaps, etc. The acidic heteropolysaccharides are compounded in an amount of 0.001-10pts.wt. based on 100pts.wt. of the surfactant.
PURPOSE OF REVIEW: Obesity and type 2 diabetes (T2D) are increasingly common, chronic, and complex and disproportionally affect systemically under-resourced communities negatively impacted by social determinants of health. The primary goals of management for both conditions are improvement of medical and psychosocial well being and prevention of secondary complications. The advent of pediatric specific multidisciplinary weight management programs, bariatric surgery, and recent FDA approved medications have provided clinicians with tools to improve patient outcomes. However, implementation remains a challenge.
RECENT FINDINGS: The Chronic Care Model proposes utilization of community-based interventions to support children and families in managing chronic disease The CDC's Whole School, Whole Community, Whole Child Model provides a framework for schools to engage in this role. School-Based Health Centers (SBHCs) utilize a child-focused, multidisciplinary approach to support the medical home and overcome barriers to routine primary care, medical screenings and successful care plans for management of chronic disease. SBHCs and school-based programs have proven sustainable and effective in addressing obesity and T2D in youth, however recent studies are limited and more research evaluating impact are needed.
SUMMARY: School-based health offers an evidence-based solution to ensuring equitable and comprehensive care for obesity and T2D, particularly among at-risk communities.
Anhydrous cosmetic composition for controlling body odour or underarm wetness, the composition comprising an odor-absorbing substance and a thickener, wherein the odour-absorbing substance is a water-soluble inorganic carbonate and the thickener is an amorphous silicon dioxide. Preferably, the inorganic carbonate is sodium hydrogen carbonate. Preferably, the amorphous silica is hydrophobically modified (e.g. silica silylate, silica cetyl silylate, silica dimethyl silylate) or a hydrophilic silicon dioxide. Preferably, the composition comprises no modified clay minerals. Preferably, the composition further comprises a second odour-absorbing substance (e.g. cyclodextrin, zeolite). The composition may comprise a cosmetic oil (e.g. liquid paraffin oil) as organic carrier. Also claimed is a cosmetic product comprising an anhydrous cosmetic composition described herein. The cosmetic composition may be formulated as an aerosol comprising 90 to 70 wt.% of a hydrocarbon propellant, e.g. propane or butane. The cosmetic composition may also be in the form of a roll-on, as a textile wipe or as a cream composition. Further claimed is the use of a cosmetic composition described herein for controlling body odour and/or underarm wetness.
The operation of an application on a first device may be guided by a user operating a second device. The application on the first device may present a character on a display of the first device and obtain an audio signal of speech of a user of the first device. Audio data may be transmitted to the second device and corresponding audio may be played from speakers of the second device. The second device may present suggestions of phrases to be spoken by the character displayed on the first device. A user of the second device may select a phrase to be spoken by the character. Phrase data may be transmitted to the first device, and the first device may generate audio of the character speaking the phrase using a text-to-speech voice associated with the character.
Has tested positive for SARS-CoV-2 within appropriate timeframe (criteria vary for different study stages). Aged 16 years or older, willing and able to provide informed consent.
BACKGROUND: This was a retrospective cohort study of adult patients undergoing uncomplicated elective colectomy using the NSQIP database from January 2012 to December 2019. A colectomy is deemed uncomplicated if there are no complications reported during the hospitalization. The objective of this study was to examine the association between discharge timing and postdischarge complications in patients who undergo uncomplicated elective colectomy.
STUDY DESIGN: Patients were stratified into an early discharge group if their length of postoperative hospitalization was ≤3 days for laparoscopic or robotic approaches, or ≤5 days for the open approach, and otherwise into delayed discharge groups. The association between early discharge and any postdischarge complication was examined using unadjusted logistic regression after propensity score matching between early and delayed discharge groups.
RESULTS: Of the 113,940 patients included, 77,979, 15,877, and 20,084 patients underwent uncomplicated laparoscopic, robotic, and open colectomy, respectively. After propensity score matching, the odds of a postdischarge complication were lower for the early discharge group in laparoscopic (odds ratio 0.73, 95% CI 0.68 to 0.79) and robotic (odds ratio 0.63, 95% CI 0.52 to 0.76) approaches, and not different in the open approach (odds ratio 1.02, 95% CI 0.91 to 1.15). There were no clinically meaningful differences in the risk of return to the operating room for all surgical approaches.
CONCLUSIONS: Early discharge after uncomplicated colectomy appears to be safe and is associated with lower odds of postdischarge complications in minimally invasive approaches. Our findings suggest that surgical teams practice sound clinical judgments on selecting patients who benefit from early discharge.