anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Psychological stress increases risk of gastrointestinal tract diseases. However, the mechanism behind stress-induced gastrointestinal injury is not well understood. The objective of our study is to elucidate the putative mechanism of stress-induced gastrointestinal injury and develop an intervention strategy. To achieve this, we employed the restraint stress mouse model, a well-established method to study the pathophysiological changes associated with psychological stress in mice. By orally administering gut-nonabsorbable Evans blue dye and monitoring its plasma levels, we were able to track the progression of gastrointestinal injury in live mice. Additionally, flow cytometry was utilized to assess the viability, death, and inflammatory status of splenic leukocytes, providing insights into the stress-induced impact on the innate immune system associated with stress-induced gastrointestinal injury. Our findings reveal that neutrophils represent the primary innate immune leukocyte lineage responsible for stress-induced inflammation. Splenic neutrophils exhibited elevated expression levels of the pro-inflammatory cytokine IL-1, cellular reactive oxygen species, mitochondrial burden, and cell death following stress challenge compared to other innate immune cells such as macrophages, monocytes, and dendritic cells. Regulated cell death analysis indicated that NETosis is the predominant stress-induced cell death response among other analyzed regulated cell death pathways. NETosis culminates in the formation and release of neutrophil extracellular traps, which play a crucial role in modulating inflammation by binding to pathogens. Treatment with the NETosis inhibitor GSK484 rescued stress-induced neutrophil extracellular trap release and gastrointestinal injury, highlighting the involvement of neutrophil extracellular traps in stress-induced gastrointestinal inflammation. Our results suggest that neutrophil NETosis could serve as a promising drug target for managing psychological stress-induced gastrointestinal injuries.
Adults

The efficacy of escitalopram oxalate in the treatment of generalized anxiety disorder (GAD) in adults was demonstrated in three, 8-week, multicenter, flexible-dose, placebo-controlled studies that compared escitalopram oxalate (10 mg to 20 mg daily) to placebo in outpatients between 18 and 80 years of age who met DSM-IV criteria for GAD. In all three studies, escitalopram oxalate showed statistically significant greater mean improvement compared to placebo on the Hamilton Anxiety Scale (HAM-A).

There were too few patients in differing ethnic and age groups to adequately assess whether or not escitalopram oxalate has differential effects in these groups. There was no difference in response to escitalopram oxalate between men and women.

Additional pediatric use information is approved for AbbVie Inc.’s LEXAPRO (escitalopram) oral solution. However, due to AbbVie Inc.’s marketing exclusivity rights, this drug product is not labeled with that information.
A multicomponent homogeneous polymer of (a) from about 30 to about 90 wt. % of a N-vinyl lactam, (b) from about 5 to about 30 wt. % of a quaternized and/or non-quaternized aminoalkylacrylic -ester and/or -amide, (c) from about 0.5 to about 30 wt. % of an unsaturated monomer selected from the group consisting of an acrylic ester or amide having a C4 to C22 alkyl group, a C4 to C22  alpha -olefin, a C4 to C22 vinyl ether (VE) and a vinyl ester of a C2 to C22 carboxylic acid and (d) from about 1 to about 30 wt. % of an unsubstituted acrylic or methacrylic acid and/or an unsubstituted amide of said acrylic or methacrylic acid and optionally, (e) up to 20 wt. % of a mono- or di-functional polysiloxane; all monomers combined to form a 100% polymer composition of randomly distributed monomers for use in personal care formulations, particularly as a hair fixative where the clear, colorless and conditioning film forming properties of the polymer produces a silky, lustrous appearance to the hair and long lasting styling hold.
FIELD: medicine.SUBSTANCE: biocompatible implant (BI) made of magnetic material in a biocompatible matrix (BM) is placed loosely along a posterior surface of an injured spinal cord of an experimental animal (EA) The EA is immersed periodically into a constant magnetic field. Its magnetic vector is aligned with a craniocaudal direction of spinal tracts. The BM of the BI is animal or herbal gelatine, wherein ferromagnetic magnetite or ferromagnetic ferrite nanoparticles 18-42 wt % with a particle size of 2.0-38 nm and at a magnetic field intensity (N) of 5-10 mT are immobilised as a magnetic material of the BI. The magnetic exposure covering the traumatic spinal injuries involves the combined effect of the magnetic field of the BI and the external rotating magnetic field at a magnetic induction of 0.15-0.35 T. The external magnetic exposure frequency is 1 or 2 times a day; the length is from 2 to 8 minutes per one session; the number of sessions is from 2 to 4. Animal gelatine in the BM of the BI can represent agar-agar, whereas herbal gelatine is pectin. The BM of the BI can additionally contain polyamines contributing to cell growth and proliferation, e.g. spermine or spemidine, in an amount of 1-5 wt %.EFFECT: method enables recovering the spinal cord function sufficiently completely in the distal direction from the injury region, providing the favourable conditions for the adequate neuroglial growth with recipient's long neuron penetration from the intact proximal portion of the spinal cord into the distal one to ensure its conductive function, reducing the cicatrisation within the spinal injury, and eliminating the cerebral tissue oedema.3 cl, 8 ex
The natural cosmetic market is a multi-billion-dollar industry. Nutraceuticals and foodbased cosmetics are a growing trend within dermatology. Almonds are a rich dietary source of a range of fatty acids, phytochemical polyphenols, and antioxidants \[1\]. The previous study done by Dr. Raja Sivamani was a double blinded study that compared oral almond intake to a calorie matched non-nut-based intake over 12 weeks.The study determined that that there was a statistically significant improvement in wrinkle severity and pigment intensity in the women that received almond supplementation. This proposal aims to now understand how the topical application of almond oil may influence the appearance of wrinkles and facial tone in post-menopausal women. Almond oil is rich in fatty acids and alpha-tocopherol \[2\]. Tocopherol inhibits melanogenesis in melanocytes \[3\] and topical alpha tocopherol has been shown to improve skin antioxidants and hyperpigmentation \[4, 5\].
This will be an open label trial for those with Hamilton Depression Rating Scale score ≥ 8 following the minocycline v. placebo trial or those not eligible for Phase 2. Dose of celecoxib will be 100 mg bid for the first week and 200mg bid for weeks 2-8. For tapering, the dose of celecoxib will be reduced to 100mg bid for one week, and then stopped.
The present invention relates to a Chinese traditional patent medicine for treating diabetic hypertension, which takes more than 10 Chinese herbal medicines of red ochre, dogbane leaf, fried immature bitter orange, and bamboo shavings etc. as the raw materials. The present invention has the effects of removing dampness, resolving phlegm, regulating qi and lowering blood pressure. Based on the differential treatment of the traditional Chinese medicine, the invention is developed by combining the latest scientific research results with the traditional Chinese medicine. The present invention aims at providing the Chinese traditional patent medicine to treat diabetic hypertension. The present invention is characterized by accurate efficacy, safety, convenience, no toxicity or side effects and low price.
In the standard arm, patients will receive conventional antipyretics and Tocilizumab at first clinical signs (being grade 1 or higher) of emerging CRS. Tocilizumab will be given at the standard-dose of 8 mg/kg b.w. intravenously over one hour in 250 ml NaCl 0.9%, and it will be repeated after 8 hours for a maximum of four administrations in patients with ongoing signs of CRS. Prior to Tocilizumab administration, no specific premedication is given.
Retrospective anonymized Berg Balance Score data of stroke inpatients was collected from an institutional report for fiscal year 2018. 2018 was chosen as it preceded the implementation of the ZeroG body weight support system and reflects a no-intervention control baseline. This data was then filtered to show only patients with a Berg score of 21 or greater to match the study's inclusion criteria.
Patients receive oral BMS-275291 once daily on days 1-28. Treatment repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients achieving a CR receive 2 additional courses beyond CR.
This study aimed to investigate associations between neighborhood perception and sleep problems in older Brazilian adults. A cross-sectional study was conducted with 5,719 community-dwelling older adults (≥ 60 years) from the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2019-2021). The outcomes were self-reported sleep problems: poor sleep quality, daytime sleepiness, primary insomnia complaints, difficulty staying asleep, and waking up at dawn. The exposure variables were questions about the perception of participants about the physical and social environment of the neighborhood. Logistic regression was used in data analysis. Garbage, rubbish, or tall grass on the streets and the desire to move were associated with higher odds of poor sleep quality. Concern about falling due to damaged sidewalks, concern about having difficulties taking transportation, and concern about having difficulties crossing the street were associated with higher odds of all sleep problems. Sound/noise of buses and cars was associated with higher odds of some sleep problems. Perceiving the neighborhood as a good place to live was associated with lower odds of daytime sleepiness and primary insomnia complaints. Trusting most people in the neighborhood and perceiving that kids and younger people treat adults with respect were associated with lower odds of daytime sleepiness, primary insomnia complaints, and waking up at dawn. Being a good place for kids to play and raise teenagers was associated with lower odds of daytime sleepiness. These results can assist public administrators in creating urban planning policies aimed at improving neighborhood environments as a means of health promotion.
Belt electrode-skeletal muscle electrical stimulation (B-SES) involves the use of belt-shaped electrodes to contract multiple muscle groups simultaneously. Twitch contractions have been demonstrated to protect against denervation-induced muscle atrophy in rats, possibly through mitochondrial biosynthesis. This study examined whether inducing tetanus contractions with B-SES suppresses muscle atrophy and identified the underlying molecular mechanisms. We evaluated the effects of acute (60 Hz, 5 min) and chronic (60 Hz, 5 min, every alternate day for one week) B-SES on the tibialis anterior (TA) and gastrocnemius (GAS) muscles in Sprague-Dawley rats using belt electrodes attached to both ankle joints. After acute stimulation, a significant decrease in the glycogen content was observed in the left and right TA and GAS, suggesting that B-SES causes simultaneous contractions in multiple muscle groups. B-SES enhanced p70S6K phosphorylation, an indicator of the mechanistic target of rapamycin complex 1 activity. During chronic stimulations, rats were divided into control (CONT), denervation-induced atrophy (DEN), and DEN + electrically stimulated with B-SES (DEN + ES) groups. After seven days of treatment, the wet weight (n = 8-11 for each group) and muscle fiber cross-sectional area (CSA, n = 6 for each group) of the TA and GAS muscles were reduced in the DEN and DEN + ES groups compared with that in the CON group. The DEN + ES group showed significantly higher muscle weight and CSA than those in the DEN group. Although RNA-seq and pathway analysis suggested that mitochondrial biogenesis is a critical event in this phenomenon, mitochondrial content showed no difference. In contrast, ribosomal RNA 28S and 18S (n = 6) levels in the DEN + ES group were higher than those in the DEN group, even though RNA-seq showed that the ribosome biogenesis pathway was reduced by electrical stimulation. The mRNA levels of the muscle proteolytic molecules atrogin-1 and MuRF1 were significantly higher in DEN than those in CONT. However, they were more suppressed in DEN + ES than those in DEN. In conclusion, tetanic electrical stimulation of both ankles using belt electrodes effectively reduced denervation-induced atrophy in multiple muscle groups. Furthermore, ribosomal biosynthesis plays a vital role in this phenomenon.
The present invention relates to boluses for eliminating arthralgia and activating energy flow in channels and collaterals and a preparing method thereof. The present invention belongs to the technical field of the medicine preparation, wherein the medicine is prepared from plant materials and is used for treating diseases, such as rheumatism or rheumatoid diseases. The bolus is prepared from the following components by proportion: phellodendron bark, atractylodes rhizome, pearl barley, radix cyathulae, pawpaw, safflower, turtle shell processed with vinegar, leatherleaf milletia, red sage root, angelica, honeysuckle, dandelion, rhizoma anemarrhenae, hemlock parsley, cortex moutan, radix paeoniae rubra, radix paeoniae alba, gentiana macrophylla, prepared frankincense myrrh, earthworm, fourstamen stephania root, figwort, cassia twig, radix rehmanniae, radix sophorae, yam rhizome, mulberry twig, honeysuckle stem, prepared nux vomica, etc. The preparing method comprises the following steps that the medicinal materials are sieved according to the specified part by weight; the prepared nux vomica is obtained by soaking, cutting, drying, adding sand to carry out stir-frying, removing sand, pulverizing and sieving; the turtle shell processed with vinegar is obtained by soaking and steaming, and subsequently, the skin, the meat, the rib and the membrane of the turtle are removed; the residual turtle shell is dried and stir-fried by adding oil and sand; frankincense and myrrh are mixed, and wheat bran is added in the mixed frankincense and myrrh to stir-fry so as to form the frankincense myrrh. 26 kinds of medicines, such as the phellodendron bark, etc. are respectively processed according to the conventional method. The medicinal materials are mixed, pulverized and sieved, and subsequently, the medicinal materials are weighed by an equivalent incremental method. Consequently, wet boluses are prepared, dried, inspected and packed to form the boluses. The present invention.
Glycosylated Antitumor Ether Lipids (GAELs) kill cancer cells by a nonapoptotic pathway which is an attractive strategy to avoid resistance. To further optimize the antitumor effect, we prepared various analogs of di-, and tri-cationic GAEL analogs differing in the nature of the sugar (D-giucose or L-glucose), the anomeric linkage as well as position of the glycerolipid moiety. The di- and tri-cationic GAELs were synthesized and their in vitro anticancer properties were evaluated against drug resistant and aggressively growing cancer cell lines derived from human breast, prostate, pancreatic and ovarian cancers. The most potent dicationic GAEL analogs were also studied against cancer stem cells obtained from breast BT 474, prostate DU145 and ovarian A2780cp cell lines. Our results indicate that the number of positive charges, the position of the amino substituents and the nature of the sugar have significant effects on the anticancer activities of these compounds. The most active analog kill 50% of the cells at concentration range of 0.5-5 μM and 90% of the cells at the concentration of 1-10 μM depending on type of cancer cells.
Patients receive platinum based doublet chemotherapy consisting of low dose carboplatin and paclitaxel, standard etoposide cisplatin or carboplatin or standard pemetrexed with cisplatin or carboplatin weekly for up to 6 weeks at the discretion of the treating medical oncologist. Patients also undergo lower dose proton beam radiation therapy daily for a total of 60 Gy for up to 30 weekdays in the absence of disease progression or unacceptable toxicity.
Emerging evidence suggests the role of alternate-day fasting (ADF) in patients with obesity and fatty liver. It helps to lose weight and improvement in liver fat content. ADF regimen protocol includes fast day(restricted calorie intake and time-specific feeding) and feast day(ad libitum feed over 24 hours). Lowering the weight and improvement of the fatty liver. NASH is a prevalent cause of liver disease. Literature is evident that ADF improves fatty liver and metabolic components, and NASH improves with weight loss. Still, data about the role of ADF in the management of NASH is lacking. Hence, this study focuses on the role of ADF in NASH.
This prospective observational study was conducted with 92 patients aged 18 - 45 years who had amniocentesis at 15 - 22 weeks of gestation at Bursa Yüksek İhtisas Training and Research Hospital between April 15, 2021 and April 15, 2022. Patients were divided into two groups according to amniocentesis indications. Group 1: patients with abnormal maternal serum screening test or prenatal diagnosis test, patients with abnormal ultrasonography findings (45 patients), Group 2: patients with pre-diagnosis of NTD (47 patients). During the amniocentesis procedure, the first 5cc amniotic fluid and maternal serum samples were collected from the patients. The obtained samples were stored at -80°C until the end of the study. After all samples were collected, BPA values were measured by ELISA method.
The present invention solves the problem of providing a novel anti-CD 147 antibody having excellent anti-tumor activity and excellent safety. The invention also solves the problem of providing a medicament comprising such an antibody. The present invention also solves the problem, inter alia, of providing a method for the treatment of tumors in which said antibody or drug is used. The present invention provides CD147 specific antibodies that activate CD147 and demonstrate a strong anti-tumor effect. The present invention provides anti-CD 147 antibodies that demonstrate a strong anti-tumor effect independent of effector function. The invention provides pharmaceutical compositions comprising such anti-CD 147 antibodies. The present invention provides methods for treating tumors using such anti-CD 147 antibodies and/or pharmaceutical compositions.
Consumption of garlic or garlic-flavoured food results in an odour nuisance which is very unpleasant, especially for other people, and is caused by effluvium from the body and mouth odour and can be eliminated only inadequately or not at all by previous means such as body hygiene, use of deodorants, oral hygiene, sucking pastilles and the like. The novel composition is intended to eliminate the described odour rapidly, completely and permanently in a very simple and harmless way. The body and mouth odour is eliminated by a mixture, to be taken orally, of melissa and thyme. An outstandingly suitable combination is one of lemon balm (Melissa officinalis) and true thyme (Thymus vulgaris), which are taken, for example, in the form of dried powdered leaves in a mixing ratio of 1:1. Both other species of the two specified herbs and administration in a modification like an extract or mixed with liquids are conceivable. The composition is suitable, by reason of its constituents, as pure natural product for the elimination of unpleasant mouth and body odour caused by garlic virtually without exception for everybody. Adverse side effects appear to be precluded.
In central nervous system (CNS), demyelination is a pathological process featured with a loss of myelin sheaths around axons, which is responsible for the diseases of multiple sclerosis, neuromyelitis optica, and so on. Transforming growth factor-beta1 (TGF-β1) is a multifunctional cytokine participating in abundant physiological and pathological processes in CNS. However, the effects of TGF-β1 on CNS demyelinating disease and its underlying mechanisms are controversial and not well understood. Herein, we evaluated the protective potential of TGF-β1 in a rodent demyelinating model established by lysophosphatidylcholine (LPC) injection. It was identified that supplement of TGF-β1 evidently rescued the cognitive deficit and motor dysfunction in LPC modeling mice assessed by novel object recognition and balance beam behavioral tests. Besides, quantified by luxol fast blue staining, immunofluorescence, and western blot, administration of TGF-β1 was found to significantly ameliorate the demyelinating lesion and reactive astrogliosis by suppressing p38 MAPK pathway. Mechanistically, the results of in vitro experiments indicated that treatment of TGF-β1 could directly promote the differentiation and migration of cultured oligodendrocytes. Our study revealed that modulating TGF-β1 activity might serve as a promising and innovative therapeutic strategy in CNS demyelinating diseases.
FIELD: chemistry; biochemistry. ^ SUBSTANCE: invention pertains to biotechnology. The invention describes a method of producing a modified vitamin K dependent polypeptide which involves modification of activation peptide which includes at least part of an amino acid sequence of another vitamin K dependent polypeptide and where the said part is at least 3 adjacent amino acids of activation peptide FVII, or 5 adjacent amino acids of activation peptide FX, or 5 adjacent amino acids of activation peptide FIX provided that QSFNDFTR peptide is excluded, or 8 adjacent amino acids of activation prothrombin peptide, or an extension on adjacent amino acids of the activation peptide of the second vitamin K dependent polypeptide which has length at least equal to 15% of the total length of the amino acid sequence of the activation peptide of the second vitamin K dependent polypeptide, in which the second vitamin K dependent polypeptide is selected from a group consisting of protein Z, GAS6 and protein S, and where the second vitamin K dependent polypeptide has longer half-life in plasma. The invention discloses a modified vitamin K dependent polypeptide obtained using the described method and having coagulation activity. ^ EFFECT: invention enables production of modified vitamin K dependent polypeptides with longer half-life in plasma. ^ 40 cl, 2 dwg, 4 tbl, 7 ex
The researchers are conducting a single-blinded randomized controlled trial. All patients who meet exclusion criteria will be recruited at the time of their visit where a Pap smear will be collected at an ob/gyn clinic. If patients agree to participate in the study, they will be randomized into one of two arms. A control arm or an interventional arm. The control arm just includes physician counseling regarding cervical cancer screening/prevention, while the interventional arm includes patient's watching a video on cervical cancer screening/prevention as well as physician counseling. Patient will be administered a survey before and after to assess knowledge and satisfaction scores.