anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nearly 50% of U.S. cigarette smokers smoke ≤ 10 cigarettes per day (CPD) and are considered "light smokers." Most light smokers will either maintain a chronic light smoking habit or increase their level of smoking during their lifetime. Importantly, light smokers are at risk for adverse health consequences and increased all-cause mortality. While multiple factors such as reinforcement behavior, diminished autonomy, economic constraints and tobacco control policies influence light smoking, nicotine dependence appears particularly important in 5 to 10 CPD smokers. Despite the high prevalence of light smoking and its increased healthcare burden, few studies have evaluated the efficacy of pharmacotherapy for this group of smokers. Varenicline, which targets symptoms of nicotine dependence, has been shown to increase smoking abstinence rates in moderate to heavy smokers (≥ 10 cigarettes per day). However, varenicline has not been evaluated in subjects who smoke \< 10 CPD. In the current proposal we will investigate the efficacy of varenicline for smoking cessation in 5 to 10 CPD light smokers who wish to quit. This study will be conducted as a double-blind, placebo-controlled, randomized clinical trial at the Mayo Clinic, enrolling 224 eligible participants who smoke 5 to 10 CPD. Participants will receive behavior therapy and either varenicline or placebo for 12 weeks with follow up through 26 weeks. We will determine if varenicline increases smoking abstinence in light smokers at end-of-treatment and 26 weeks as compared to placebo.
Medical foods that create fertility enhancement also improve the health of a fetus or child. Multiple examples demonstrate this in mammals. To maximize this effect, the mother continues to consume the medical food into the gestation period. Both mother and fetus benefit from higher immunity and lower cortisol. Superior colostrum further builds the child's immune system. Good health as an infant foreshadows health advantages in later life.
Nicardipine hydrochloride capsules for oral administration each contain 20 mg or 30 mg of nicardipine hydrochloride. Nicardipine hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker).

Nicardipine hydrochloride is a dihydropyridine structure with the IUPAC (International Union of Pure and Applied Chemistry) chemical name 2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate monohydrochloride, and it has the following structural formula:

NICARDIPINE HYDROCHLORIDE C26H29N3O6•HCl 

Nicardipine hydrochloride, USP is a greenish-yellow, odorless, crystalline powder that melts at about 169°C. It is freely soluble in chloroform, methanol, and glacial acetic acid, sparingly soluble in anhydrous ethanol, slightly soluble in n-butanol, water, 0.01 M potassium dihydrogen phosphate, acetone, and dioxane, very slightly soluble in ethyl acetate, and practically insoluble in benzene, ether and hexane. It has a molecular weight of 515.99.

Each capsule, for oral administration, contains 20 mg or 30 mg of nicardipine hydrochloride, USP. In addition, each capsule contains the following inactive ingredients: colloidal silicon dioxide, gelatin, magnesium stearate, pharmaceutical glaze, pregelatinized starch, propylene glycol, silicon dioxide, sodium lauryl sulfate, synthetic black iron oxide, FD&C Blue No.2 Aluminum Lake, FD&C Red No.40 Aluminum Lake, FD&C Blue No.1 Aluminum Lake, and D&C Yellow No.10 Aluminum Lake. The colorants used in the 20 mg capsules are titanium dioxide, D&C Yellow No.10, and FD&C Green No.3. The colorants used in the 30 mg capsules are titanium dioxide, yellow iron oxide, and FD&C Green No.3.
PURPOSE:A hair tonic, containing an extract of mistletoe which is a herb medicine as an active constituent, safe for the human body without skin irritation and having very remarkable trichogenous and hair growth promoting effect by application. CONSTITUTION:A hair tonic obtained by using an extract of pulverized mistletoe (branch, leaf or treetop of Viscum album L. var. lutescens Makino or Loranthus yadoriki Sieb. of the family Loranthaceae) with a solvent, e.g. methanol, water or ethyl acetate, etc. The above-mentioned extract is preferably used in an amount of 0.1-5wt% expressed in terms of a dried material in a hair tonic composition. The extract of the mistletoe alone has remarkable trichogenous effect, but use together with an extract of Angelica pubescens Maxim., polygala root, senega, glossy privet, etc., provides hair tonic effect almost equal to or somewhat better than that of the above-mentioned extract.
PURPOSE: A bio signal data measurement device and a method thereof are provided to improve reproducibility and data reliability by determining a compensation value after determining a reaction completion time according to a reaction speed. CONSTITUTION: A sensor(410) is arranged within a region in which a strip is inserted on a plane. A correction data generating part(470) generates correction data based on the data that is detected from the sensor. A reaction completion time determining part(460) determines the reaction completion time based on the data detected from sensor. A bio-signal data measuring part(440) measures the bio-signal data based on the data that is detected from the sensor and the correction data. An output part(480) outputs the bio-signal data to the outside.
The influence of gut microbiota on gut health is well-documented, but it remains obscure for extraintestinal diseases such as breast cancer. Moreover, it is entirely unknown how gut dysbiosis during early life contributes to breast tumorigenesis later in life. In this study, we hypothesized that a high-fat diet during early life leads to alterations in the gut microbiome and is associated with disruptions in the mammary microenvironment. Female C57BL/6 mice were fed a low-fat diet (10% kcal fat) or a high-fat diet (HF, 60% kcal fat) for 8 weeks from the age of 4 to 12 weeks, which is equivalent to human childhood and adolescence. Twelve mice were sacrificed immediately after the 8-week feeding, the remainder were euthanized after switching to a normal lifecycle-supporting diet for an additional 12 weeks; the gut microbiome was then sequenced. The 8-week HF diet feeding altered the beta-diversity (Bray & Jaccard P < .01), and the difference remained significant after switching the diet (Bray & Jaccard P < .05). Immediately after HF feeding, a greater number of microbial taxa (>50) were altered, and about half of the taxa (25) remained significantly changed after switching the diet. The abundance of Alistipes, Bilophila, and Rikenellaceae stood out as significantly associated with multiple metabolic and inflammatory biomarkers in mammary tissue, including aromatase, Ccl2, and Cox2. In conclusion, an 8-week early-life HF feeding reshaped the gut microbiome, which connected with disrupted mammary microenvironments.
A method for health education, certification, and recordation is disclosed. The method may include obtaining, at a server, a user input from a user interface. The user input may define an interval for a desired CPR certification schedule. The method may include generating, at the server, a CPR certification program. Generating the CPR certification program may include generating at least two task groups. Each task group of the at least two task groups may include a healthcare certification task. The method may include administering, at the server, the CPR certification program. Administering the CPR certification program may include assigning, at the interval defined by the user input, one task group of the at least two task groups to a user enrolled in the CPR certification program, and receiving an indication that the enrolled user has completed the healthcare certification task of the assigned one task group.
The MPT group participated in 3-one hour supervised training sessions per week for 12 weeks. All MP sessions were performed in nonconsecutive days. The MP sessions were divided into the following stages: initial warm up and stretching (10 min), general conditioning consisting of MP exercises (40 min) and stretching and cooling down (10 min). The participants performed 12 basic MP exercises (one set of 6-10 repetitions was performed per exercise). Breathing, a core principle of MP, was performed by forced but controlled inspirations and exhalations, while relaxing and contracting the abdomen, respectively. All sessions were supervised by a certified MP instructor.
OBJECTIVES: I. Evaluate whether immunostaining of induced sputum specimens improves the sensitivity and specificity of routine morphologic sputum surveillance to detect second primary lung cancer in patients with previously resected nonsmall cell lung cancer. II. Evaluate which patients are at risk of developing a second primary lung cancer by immunostaining specimens from patients with no morphologic atypia on routine Papanicolaou cytology. III. Make available archived sputum samples and bronchial washings for further analysis of new antibodies and techniques. IV. Evaluate whether analysis of elevations of relevant growth factors in bronchial lavage fluid from patients with positive immunostaining or morphologic atypia increases the accuracy of early detection. V. Evaluate whether quantitation of shed antigens in sputum increases the accuracy of early detection. VI. Evaluate whether the extent of airway obstruction, as measured by the forced expiratory volume, can predict an increased risk of developing lung cancer.

OUTLINE: Screening for Second Primary Lung Cancer. Annual sputum induction for Papanicolaou cytology and immunostaining (using monoclonal antibodies 624H12 and 703D4), with optional pulmonary function tests and fiberoptic bronchoscopy with bronchial washings.

PROJECTED ACCRUAL: 1,100 patients will be entered over 3 years. The sample size will be adjusted based on the rate of positive staining in the first 100 patients. Patients followed at uncertified centers are analyzed separately.
The invention discloses a traditional Chinese medicine for treating nephritis. The medicine provided by the invention is made from the following raw materials of: rehmanniae radix, imperata rhizome, porcine Poria cocos, Poria cocos, bighead atractylodes rhizome, licorice, dried orange peel, Villous Amomum Fruit, Eclipta prostrata L, Forsythia Suspensa, powdered steatile, Alisma Orientalis, banksia rose and areca peel. The medicine is prepared by steps of: adding 600ml of water into the 14 traditional Chinese medicines, decocting on slow fire until the mixture reaches 250ml, and filtering. The filtrate is uniformly divided into two parts for oral administration. One portion of the filtrate is taken a day. Two treatment courses are required in general and nephritis can be treated after 14 days. The medicine provided by the invention has efficacy of clearing heat and cooling the blood, is used for treating epidemic febrile disease, is characterized by heat invasion and blood nourishing, has functions of clearing heat, nourishing yin and promoting the production of body fluid to quench thirst, is used for completely treating nephritis with no recurrence and no side-effect. The cure rate of the medicine reaches 96.9%.
An earlier observational study described selected patients with acute neck pain syndrome, who experienced short bursts of cervical vertigo elicited by rapid head movements. The current study on a larger cohort of 20 patients with chronic or frequently recurring neck pain syndrome and age-matched controls focused on two major questions: (1) Can head movements in subjects with exacerbations of neck pain and restrictions of neck mobility also elicit bursts of vertigo? (2) What is the impact on postural balance measured by analysis of body sway and locomotion? A detailed questionnaire was applied, posture and gait were evaluated by use of instrumented posturography-and gait analysis with and without slow or rapid horizontal head rotations in the yaw plane with and without sight/visual input. All patients reported some or frequent episodes of dizziness in the range of seconds only elicited by rapid, not by slow head movements. Postural sway in patients was unremarkable in undisturbed conditions without head movements, but specifically increased by rapid but not slow head turns. The latter is best explained by the lack of continuous control of velocity and amplitude of saccadic head movements. Gait analysis revealed a slowed and cautious gait pattern already at undisturbed condition that was even exaggerated during rapid head turns. These observations demonstrate that chronic or recurrent neck pain is associated with episodic experiences of dizziness and above results in both chronic and episodic alterations of stance and gait that resemble those described for patients with phobic postural vertigo/persistent postural perceptual dizziness, a functional gait disorder.
This is a multi-centre, double-blind, double-dummy, randomised, controlled study to evaluate the efficacy and safety of TDF 300mg QD versus ADV 10mg QD in Chinese subjects with CHB. Four hundred and ninety-four subjects with CHB (200 HBeAg positive subjects and 294 HBeAg negative subjects) will be randomised (1:1ratio) to either TDF 300mg QD or ADV 10mg QD treatment arms. The primary endpoint is the proportion of subjects with blood hepatitis B virus (HBV) deoxyribonucleic acid (DNA) \<400copies/mL (Roche COBAS Taqman HBV test) at Week 48 in HBeAg positive subjects with CHB and HBeAg negative subjects with CHB. This is a two-part study. The first treatment period (baseline to Week 48) will investigate the effects of TDF and ADV on safety and efficacy endpoints; dosing will be double-blind. This period will be followed by 192 weeks in which all subjects will receive open-label TDF (Week 49 to Week 240). Subjects will undergo regular safety and efficacy assessments every 4 weeks for the first 12 weeks followed by every 12 weeks for a total of up to 5 years.
Ultrasound is a widely accepted and highly useful clinical tool. It carries the additional advantage of being rapid, painless and non-radiating. It has long been used to assess cardiac output and vascular pathologies. More recently emergency and trauma clinicians have been using it to assess hydration status, shock/sepsis states and fluid responsiveness. Using sonography to look at the inferior vena cava gives clinician a rapid view of vascular collapsibility that has been previously demonstrated to correlate with mean arterial pressure (MAP) and central venous pressure (CVP). Previously, Jones et. al. completed an randomized controlled trial (RCT) in adults greater than age 17 evaluating the goal directed utility of early versus delayed inferior vena cava sonography for patients presenting with non traumatic hypotension to the emergency department. This study found improved outcomes and more accuracy in diagnostic etiology in those undergoing immediate IVC imaging. The study conducts a randomized controlled trial of IVC Ultrasonography in pediatric patients 0-21 year of age.

Patients admitted to the Emergency Department and triggering triage STOP SEPSIS ALERT (based on triage vital signs and chief complaint), vomiting requiring zofran or diarrhea with concern for dehydration/hypovolemia, the treating physician believes would benefit from intravenous fluids, will be eligible for inclusion into this study. The "treating physician" refers to one of the Pediatric Emergency Medicine attendings or fellows, listed as co-investigators. Only if and when a patient or parent expresses interest in participating in the study, the attending or fellow caring for the patient will determine if the patient is eligible. If the patient is eligible, and has no criteria that would exclude them from the study, written informed consent will be obtained from the guardian and assent will be obtained in children \> 7 years old. The patient will be enrolled in the study and randomized to either the immediate ultrasonography group (Ultrasound (US) of the Inferior Vena Cava (IVC) first before the clinician fully assesses the patient and places rehydration orders) or the control group (US at 15 minutes into the assessment and management of the patient). The goal will be to assess how the use of ultrasound impacts clinical management and outcomes in patients presenting to the pediatric emergency department with sepsis and dehydration.
PURPOSE: This study aimed to develop knowledge of how the follow-up regarding overweight and obesity among children in primary school is experienced by the PHN and how the guidelines may be used to improve health services in this follow-up.
METHODS: We analysed semi-structured interviews of 9 PHNs using qualitative content analysis.
RESULTS: Two themes emerged: Following up with children with overweight and obesity is an important but challenging duty; The PHNs call for clearer guidelines. Following five sub-themes: PHNs strive to adhere to the guidelines, show compassion in the follow-up, have difficulty handling parents' feelings and reactions, feel alone with the responsibility, and have suggestions for clearer guidelines.
CONCLUSIONS: PHNs call for enough resources to communicate the results of the child's weight in a sufficient form. PHNs and families should establish common goals. The PHN should avoid one-way communication but meet the parents' concerns and needs. This requires the PHN to focus on building a secure relation to the child and the families, as described by Peplau. Guidelines must include instructions and tools on how to communicate and meet the family's concerns. Political action and increased funding could strengthen the follow-up and thereby prevent more obesity among children, which can be a predictor of poorer health outcomes later in life.
The invention relates to a synbiotic (probiotic plus prebiotic) for human purposes, which will be used as a food additive to produce targeted beneficial effects on human health. The synbiotic is a mixture of monocultures: Lactobacillus acidophilus N 180, N NBIMCC 8242, Lactobacillus helveticus N 173, N NBIMCC 8268, Lactobacillus helveticus N 179, Lactobacillus delbrueckii subsp. bulgaricus N 182,NBIMCC 8250, Lactobacillus delbrueckii subsp. bulgaricus N 186, N NBIMCC 8243, Lactobacillus delbrueckii subsp. bulgaricus N 190, N NBIMCC 8247, Streptococcus thermophilus N 205, N NBIMCC 8253, Bifidobacterium bifidum N PB-bl, N NBIMCC 8328, Bifidobacterium longum NPB-b3, N NBIMCC 8329. The newly isolated strains of lactic acid bacteria and bifidobacteria individually and collectively provide the highest probiotic effect; they show good survivability in acid environment, produce a significant amount of bacteriocins, which inhibit the total quantity of conditionally pathogenic microorganisms in the gastrointestinal tract. Besides, the synbiotic components provide each other optimal conditions for staying in the mucosa and development and propagation of the cultures. Thanks to their rich content of indispensable amino acids and biologically active substances, they help increase the overall health status of the organism.
A complex admixture of amino acid salts of iron is obtained by enzymatically digesting a proteinous material to free amino acids therefrom and reacting the resulting mixture with an iron hydroxide, hydrated oxide or carbonate.  The reaction may be carried out at room temperature in the range 60-80 DEG  C.  If desired, the amino acid mixture may be first reacted with a soluble salt of a metal other than iron and the required iron salts obtained by double decomposition.  Suitable proteinous starting materials are, for example, casein, gelatine, yeast, soya bean flour, egg albumen, vegetable or animal albumen or a mixture of two or more such proteinous substances.  The digestion may be carried out under acid, neutral or alkaline conditions.  With acid digestion pepsin is added to the proteins as an enzymatic agent. In neutral digestion the preferred enzymatic agent is papain and with alkaline digester pancreatic extract is preferred.  The pH value of the resulting mixture is adjusted to from 3.6 to 4.6. Iron hydrate, hydroxide or carbonate is mixed with the amino acids either substantially pure or mixed with unconverted proteins, peptones and the like in proportions to give the mixture a pH value of 6.5 to 7.  In the example a mixture of casein, gelatine and water are subjected to enzymatic hydrolysis by pancreatic extract; the pH value is adjusted to between 7.3 and 8.0 by the addition of sodium carbonate and when hydrolysis is 60-70 per cent complete the pH value is adjusted to 4.3 by the addition of sulphuric acid; iron hydroxide is then added and a clear solution is obtained after filtration, which may be concentrated to any degree required.
An observational cross-sectional study was carried out with the aim of determining associations between quality of sleep and harmful oral habits among children aged three to six years. This study was conducted in compliance with the Brazilian National Health Council/Ministry of Health guidelines contained in Resolution 196/96 and received approval from the Human Research Ethics Committee of the Universidade Metropolitana de Santos (Brazil) under process number 026/2010. Parents/guardians of all participants were properly informed regarding the objectives of the study and signed a statement of informed consent.

Fifty children (3 to 6 years of age) from a private school in the city of Sao Paulo were evaluated by means of two questionnaires administered to parents/guardians: The "Undesirable Habits Questionnaire", composed of 15 investigative questions on harmful oral habits as well as dietary and psychological factors, and the Sleep Habits Questionnaire.6 The data were submitted to descriptive analysis. The chi-square test was employed for the categorical variables and analysis of variance (ANOVA) was carried out to compare mean values. The Student's t-test was used for all analyses, with the significance level set at 5%. The SPSS 12.0 program for Windows was used to analyze the results.
1,201,332. Phytohaemagglutinin. WELLCOME FOUNDATION Ltd. 13 Sept., 1967 [30 Sept., 1966], No. 42046/66. Heading A5B. Phytohaemagglutinin with an increased relative content of mitogenic component is prepared by extracting the crude phytohaemagglutinin into an aqueous medium, precipitating the proteinous components with an inorganic salt such as ammonium sulphate, or an organic solvent, e.g. ethanol, re-dissolving the precipitate in an aqueous medium removing unwanted proteinous components which are rendered insoluble by dialysis, preferably at pH 6.8 to 7, at low ionic strength of below 0.05M, applying the proteinous components to an adsorbent comprising cellulose phosphate, calcium phosphate alumina Cy gel, carboxymethyl cellulose or sulphoethyl cellulose and eluting the proteinous components from the adsorbent to provide a fraction rich in mitogenic component. Preferably cellulose phosphate at pH 4.5 to 7 is employed as adsorbent The dialysed solution or eluent from the adsorbent may be chromatographed on a cross-linked xerogel, e.g. dextran cross-linked with glyceryl bridges to remove impurities.