anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Anhedonia, a transdiagnostic symptom present in many neuropsychiatric disorders, differs in males and females. Parietal EEG alpha asymmetry is associated with reduced arousal and low positive emotionality, and is, therefore, a promising neurophysiologic biomarker of anhedonia. To date, however, no prior studies have determined whether this measure captures sex differences in anhedonic expression. This preliminary study (N = 36) investigated whether anhedonia severity is associated with EEG resting-state parietal alpha asymmetry in adults and whether sex moderates this relationship. Results showed that there was a significant moderating effect of sex such that, only for females, higher levels of anhedonia were associated with increased parietal alpha asymmetry. These findings suggest that parietal alpha asymmetry is a promising biomarker of anhedonia severity in female adults and reinforces the need to account for sex differences in future research.
BACKGROUND: Bone and joint infections represent a major public health issue due to their increasing prevalence, their functional prognosis and their cost to society. Phage therapy has valuable anti-biofilm properties against prosthetic joint infections (PJI). The aim of this study was to establish the proportion of patients eligible for phage therapy and to assess their clinical outcome judged against all patients presenting with PJI.
METHOD: . Patients admitted for periprosthetic joint infection (PJI) at a French general hospital between 2015 and 2019 were retrospectively included. Eligibility for phage therapy was determined based on French recommendations, with polymicrobial infections serving as exclusion criteria. Patients were categorized into two groups: those eligible and those ineligible for phage therapy. We analyzed their characteristics and outcomes, including severe adverse events, duration of intravenous antibiotic therapy, length of hospitalization, and relapse rates.
RESULTS: . In this study, 96 patients with PJI were considered in multidisciplinary medical meetings. Of these, 44% patients (42/96) were eligible for additional phage therapy. This group of patients had a longer duration of intravenous therapy (17 days vs. 10 days, p = 0.02), more severe adverse events (11 vs. 3, p = 0.08) and had a longer hospital stay (43 days vs. 18 days, p < 0.01).
CONCLUSION: . A large number of patients met eligibility criteria for phage therapy and treatment and follow-up is more complex. A larger epidemiological study would more accurately describe the prognosis of eligible patients.
If patients are randomized to the dual mobility cohort, they will receive a dual mobility prosthesis at the surgeon's discretion. All surgeries will be performed via the posterior approach, per the participating surgeon's usual standard. Patients will be on postoperative hip precautions for 6 weeks, per departmental protocol. No braces will be utilized.
The invention relates to a traditional Chinese medicine composition for treating angina and acupoint combined acupuncture and moxibustion application. The composition is prepared from the following traditional Chinese medicinal raw materials by weight: 75g of rhizoma cyperi, 75 of sanders, 75g of syzygium aromaticum, 75g of olibanum, 75g of resina liquidambaris, 225g of piper longum, 25g of borneol, 200g of storax oil, 100g of honey and the like. After the medicines are combined, the composition has the functions of regulating qi and resolving depression, warming the middle warmer and calming the adverse-rising energy, warming kidney and activating yang, promoting blood and qi circulation, inducing menstruation to relieve menalgia, diminishing swelling and promoting granulation, activating blood circulation and eliminating toxicant and the like. For compatibility of medicines, main acupoints such as Neiguan Point and Jianshi Point and standby acupoints such as Tongli Point, Zusanli Point are combined, and acupoints are stimulated by acupuncture to form a physical simulating point therapy. The composition and the point therapy are combined to realize the effect of optimally treating angina. Through the synergistic effect of efficacy, the composition can treat both symptoms and root courses, so that the immunologic function of the body is improved and protected, and moreover, the composition is remarkable in curative effect, simple in method, short in course of treatment, simple and feasible in medicament, quick in curative effect, good in effect and low in cost.
Bankart Procedure: the participant will be placed in the lateral decubitus or beach chair position. Standard diagnostic arthroscopy will be performed. The anterior capsulolabral complex will be freed from the anterior aspect of the scapular neck. The anterior aspect of the scapular neck will be decorticated using a motorized burr. A capsuloligamentous repair will be performed with the capsule shifted from inferior to superior and repaired on the glenoid face. The number of anchors used for the repair will be left to the discretion of the surgeon. Patients will be given a sling for 4 weeks, and participation in sports will not be allowed for 6 months.
By developing new tools for risk-assessing of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in a population at risk, the investigators expect that diagnosis can be done in an earlier stage resulting in an improved 5-year survival. A proof-of-concept RNA profiling study will be done in 20 BE and EAC patients where 2 biomaterials (tissue and plasma) and 2 RNA biotopes (micro RNA and messenger RNA) will be compared. Previously validated methodology on small RNA and messenger RNA capture sequencing on both tissue and plasma will be used to obtain high-quality data. Differential expression analysis will be done on tissue and plasma sample data. Additional in-depth data-mining will be done, amongst other focusing on structural information encoded in the transcriptome and building a multifeature classifier. These findings will be validated in a large validation cohort, followed by development of a clinical-grade quantitative Polymerase Chain Reaction (qPCR) test, ready for testing in an independent cohort.
The invention provides a capsule preparation for effectively treating lung diseases. The preparation is prepared from the following raw materials: tangerine, allium macrostemon, fructus psoraleae, elsholtzia, perilla stems, sculellaria barbata, lalang grass rhizome, hairyvein agrimony, indigo naturalis, pomegranate blossoms, dayflowers, garden burnets, semen brassicae, semen brassicae, arisaema cum bile, caulis bambusae in taeniam, rhizoma phragmitis, folium eriobotryae, amethyst, trichosanthes kirilowii maxim, semen lepidii, luffa flowers, nandina roots, medicine terminalia fruits, felwort, ophiopogon roots and flos farfarae. The traditional Chinese medicine formula is prepared by taking traditional Chinese herbal medicines as raw materials through a scientific formula and repeated verification in clinical tests. The preparation is reasonable in medicament and compatibility, remarkable in curative effect and free from toxic and side effects. The capsule preparation has the functions of dispelling wind and detoxifying, dispelling wet and resolving turbidity, reducing stasis and flowing venation and removing heat to cool blood. The patient is dredged up and down inside the body due to the efficacy and turbidity is quickly discharged from urine and stool to facilitate qi-blood circulation, thereby effectively alleviating the pain of the patient and finally quickly and thoroughly curing the lung diseases. The cure rate of the medicine is 85% and the effective cure rate is 96%.
Parastomal hernia is a common complication to a stoma which can cause considerable suffering for the patient. The conventional methods of repair available today have disappointing results with high recurrence rates and serious complications. Some of the complications can be related to the introduction of foreign material into the abdominal wall. The investigators hypothesis is that the use of autologous full-thickness skin graft as reinforcement material can offer an alternative with fewer complications and recurrences.

Patients with symptomatic parastomal hernia will be included in a prospective randomized multicenter study comparing reinforcement with conventional synthetic mesh (with the best available technique today), to full thickness skin grafts placed in an intraperitoneal position. The intervention will be blinded to the participants, nursing staff and the follow-up staff. The participants will be followed up at 3, 12 and 36 months monitoring complications, recurrences, quality of life, strength of the abdomino-lumbar girdle and calculations will be done on the health economics.
In accordance with one embodiment, a server can receive reservation information from a terminal of a user. A camera of the user can be activated. The server can acquire a user image photographed by the camera. The server can identify the user based on the user image. The server can acquire self-diagnosis information corresponding to the user. The server can generate a diagnosis result of the user based on the self-diagnosis information. The server can start a hospital reservation procedure of the user based on the diagnosis result. The server can identify the user and the hospital based on the reservation information. The server can transmit reservation information to a second terminal of a second user based on the identified user and hospital. The server can receive identification information of the user and the hospital from a terminal in which an application activated by an identifier corresponding to the hospital is installed. The server can transmit the information of the user to the second terminal in response to the received identification information. The server can transmit a reception result to the terminal of the user based on the visit and standby information of the hospital. Therefore, the present invention is capable of simplifying a hospital registration procedure for a patient.
PURPOSE:To obtain an emulsifier composition capable of being suitably used in fields such as food, cosmetics, pharmaceuticals or feedstuff, by containing glycyrrhizic acid or a salt thereof, a water soluble polyhydric alcohol having two or more hydroxyl groups in he molecule thereof and an oil phase component. CONSTITUTION:An emulsifier composition is obtained by containing glycyrrhizic acid or a salt thereof, water soluble polyhydric alcohol having two or more hydroxyl groups in the molecule thereof (e.g., ethylene glycol) and an oil phase component (e.g., tallow). In this case, the wt. ratio in the using amount of glycyrrhizic acid or a salt thereof and polyhydric alcohol is pref. 1:2-1000. Because thus obtained emulsifier composition is a uniform transparent or a translucent gel or viscous liquid, it can be directly and suitably used in various fields such as food, cosmetics, pharmaceuticals or feedstuff, for example, as a sun-care oil, a beauty liquid, jelly, a medical jelly or a lubricant.
Women aged over 60 years. Participants were allowed to participate in the study if they were able to walk independently and their health condition allowed them to perform the indicated fitness tests.
In partnership with the study partner (a person who spends 10 hours or more a week with the subject and can reliably report on the subject's condition), three tunes will be chosen for the purposes of the study. The tunes chosen will need to be related to a past meaningful, positive experience of the subject, as determined by the subject and the subject's study partner. The pieces will be restricted in duration to between 1.5 and 2 minutes each. A piece will be chosen at random and will be saved on a portable device, and subjects will be asked to listen to the melody using high quality, over-ear headphones. The total exposure time will be 10 minutes each hour over a three-hour period. The melody will be repeated as many times as necessary to complete the 10-minute period. The control intervention will involve listening to nature sounds at the same duration and administration scheme. Functional magnetic resonance imaging will be used to identify how brain networks are modulated via exposure to this music and how they associate with the clinical findings.
<P>PROBLEM TO BE SOLVED: To obtain a hair-bleaching agent and an oxidation hair dye each of which hardly gives an irritating smell, scarcely irritates scalps, and hardly gives a load to hair.  <P>SOLUTION: The hair-bleaching agent comprising the first agent containing an alkali agent and the second agent containing an oxidizing agent as a main ingredient is characterized in that the first agent contains 0.2 to 6 wt. % of ammonia and 0.1 to 20 wt. % of monoethanolamine hydrochloride and has a pH value of 8 to 12. The oxidation hair dye comprising the first agent containing at least one selected from oxidation dyes and direct dyes and an alkali agent and the second agent containing an oxidizing agent as a main ingredient is characterized in that the first agent contains 0.2 to 6 wt. % of ammonia and 0.1 to 20 wt. % of monoethanolamine hydrochloride and has a pH value of 8 to 12.  <P>COPYRIGHT: (C)2004,JPO
PCT No. PCT/JP95/02588 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 15, 1995 PCT Pub. No. WO96/19462 PCT Pub. Date Jun. 27, 1996Oxazole derivatives of the formula (I) wherein one of R and R1 is a methylsulfonylphenyl, an aminosulfonyl-phenyl or an alkylaminosulfonylphenyl, and the other is a cycloalkyl having 5 to 7 carbon atoms which is optionally substituted by lower alkyl, a thienyl optionally substituted by lower alkyl or halogen atom or a furanyl optionally substituted by lower alkyl or halogen atom, and R2 is a lower alkyl, and pharmaceutically acceptable salts thereof. The oxazole derivatives and pharmaceutically acceptable salts thereof have superior antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as an antipyretic agent, an analgesic agent and an anti-inflammatory agent with less side-effects such as disorders in the digestive tract.
Multimodal imaging approach. This includes a CXCR4 targeted PET/CT (\[68Ga\]Pentixafor) during the acute hospital stay, and serial CMR and Echo imaging.
A drug delivery composition for healing myocardial infarction (MI) is disclosed. The drug delivery composition includes a plurality of core-shell structured microbubbles and a polyvinyl alcohol (PVA) solution. The plurality of core-shell structured microbubbles is dispersed in the PVA solution. Each core-shell structured microbubble of the plurality of core-shell structured microbubbles includes a core and a shell surrounding the core. The core includes liquid perfluorohexane (PFH). The shell includes poly(D,L-lactide-co-glycolide)-heparin-polyethylene glycol-cyclic arginine glycine aspartate-platelet (PLGA-HP-PEG-cRGD- platelet), basic fibroblast growth factor (bFGF), at least one stabilizing agent, and at least a fluorescent label.
Tubes insertion using the Tube Delivery System in the operating room (OR). Physician initial tube insertion procedures in the OR (minimum of 2 subjects per investigator).
OBJECTIVE: To develop and externally validate an updated artificial intelligence (AI) prediction system for stratifying the risk of lymph node metastasis (LNM) in T2 colorectal cancer (CRC).
BACKGROUND: Recent technical advances allow complete local excision of T2 CRC, traditionally treated with surgical resection. Yet, the widespread adoption of this approach is hampered by the inability to stratify the risk of LNM.
METHODS: Data from patients with pT2 CRC undergoing surgical resection between April 2000 and May 2022 at one Japanese and one Italian center were analyzed. Primary goal was AI system development for accurate LNM prediction. Predictors encompassed 7 variables: age, sex, tumor size, tumor location, lymphovascular invasion, histologic differentiation, and carcinoembryonic antigen level. The tool's discriminating power was assessed through area under the curve, sensitivity, and specificity.
RESULTS: Out of 735 initial patients, 692 were eligible. Training and validation cohorts comprised of 492 and 200 patients, respectively. The AI model displayed an area under the curve of 0.75 in the combined validation data set. Sensitivity for LNM prediction was 97.8%, and specificity was 15.6%. The positive and the negative predictive value were 25.7% and 96%, respectively. The false negative rate was 2.2%, and the false positive was 84.4%.
CONCLUSIONS: Our AI model, based on easily accessible clinical and pathologic variables, moderately predicts LNM in T2 CRC. However, the risk of false negative needs to be considered. The training of the model including more patients across western and eastern centers - differentiating between colon and rectal cancers - may improve its performance and accuracy.
The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.
There was no evidence of carcinogenicity when valsartan was administered in the diet to mice and rats for up to 2 years at doses up to 160 and 200 mg/kg/day, respectively. These doses in mice and rats are about 2.6 and 6 times, respectively, the MRHD on a mg/m2 basis. (Calculations assume an oral dose of 320 mg/day and a 60 kg patient.)

Mutagenicity assays did not reveal any valsartan-related effects at either the gene or chromosome level. These assays included bacterial mutagenicity tests with Salmonella (Ames) and E coli;  a gene mutation test with Chinese hamster V79 cells; a cytogenetic test with Chinese hamster ovary cells; and a rat micronucleus test.

Valsartan had no adverse effects on the reproductive performance of male or female rats at oral doses up to 200 mg/kg/day. This dose is 6 times the MRHD on a mg/m2 basis. (Calculations assume an oral dose of 320 mg/day and a 60-kg patient.)
Phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP- dependent protein kinase (PAK) is essential for opening the CFTR chloride channel. A short segment containing many negatively charged amino acids (817-838, NEG2) within the regulatory (R) domain of CFTR is a critical regulator of the chloride channel activity. An isolated NEG2 polypeptide may be expressed as a separate sequence that stimulates CFTR channel openings at lowe concentrations, but that inhibits CFTR channel openings at higher concentrations. Residues in the NEG2 sequence were substituted to produce a polypeptide that exerts only an activating effect on CFTR. One such polypeptide is the Q4N2NEG2 polypeptide. Exogenous Q4N2NEG2 exerts stimulatory effects on both wild-type and mutant G551D CFTR function, without exhibiting inhibitory activity at any concentration.
The invention discloses a magnesium valproate sustained-release tablet and a preparing method thereof. The magnesium valproate sustained-release tablet is prepared from magnesium valproate, hydroxypropyl methylcellulose and a lubricating agent through the process steps of material preparing, mixing, granulating, total mixing, tabletting, aluminum-plastic packaging and the like. The magnesium valproate sustained-release tablet mainly has the antiepileptic and anti-mania treatment effects. A novel sustained release preparation is adopted, according to the definition of sustained release, the absorption efficiency of a drug entering an organism is reduced by reducing the drug release speed of the drug in the dosage form, and therefore a more stable treatment effect is achieved; the effective blood concentration can be kept in a long time, the toxic and side effects of the drug can be reduced, and drug use safety is improved. The drug is convenient to use and particularly suitable for patients with chronic diseases and improves compliance of patients. The magnesium valproate sustained-release tablet has the advantages of being high in stability, convenient to package, transport and store and the like, and the preparing method is simple, easy to implement and suitable for industrial production.
PROBLEM TO BE SOLVED: To dramatically improve the transfection efficiency by adding magnesium to a therapeutic composition for transfecting a polynucleotide into a vertebrate tissue. SOLUTION: Magnesium(Mg2+) is added to a therapeutic composition for in vivo transfection of a polynucleotide into a cell. The magnesium is preferably magnesium chloride. The therapeutic composition preferably contains 0.1-100 mM, preferably 0.1-10 mM of the magnesium. The therapeutic composition is preferably used for administration to a target cell (preferably muscle) of a vertebrate. The composition preferably contains the polynucleotide and the concentration of the polynucleotide in the composition is preferably 0.1 μg/ml to 20 mg/ml. Thereby, the composition useful for gene therapy, vaccination, etc., can be obtained.
The present invention discloses a capsule for reducing blood lipid and preventing thrombus, (trivial name is 'Yanshoumainingling') which belongs to the class of a Chinese herbal medicine preparation. Cardio-cerebrovascular disease is one kind of stubborn disease which people are beset with. Cardio-cerebrovascular disease has close relation with visceral dysfunction. The property of disease is determined by qi and blood asthenia and sthenia, patency and stasis. Cardio-cerebrovascular disease can be controlled in a certain degree by Chinese medicine and western medicine at present, but the medicine has unsatisfied cure rate, and a plurality of medicine has side effect. The present invention examines disease and determines causes by Chinese medicinal theories and combination of disease causes and symptom according to six excesses and seven emotions, reduces blood lipid, regulates organism blood fat in the two ways, is capable of being directly revive the endocrine system, strengthens the immune function and resists aging after the adopted capsule prepared from Chinese medicine of saffron crocus, ginseng, solomonseal rhizome, etc. by scientific processing is taken. The cure rate of hyperlipoidemia and cardio-cerebrovascular disease reaches 95%. The capsule has no side effect. Practice indicates that the capsule is capable of promoting lipid migration in blood, reduceshematopexis property, strengthens protein solubility, has obvious curative effect on patients with cardio-cerebrovascular disease and opens a new page for treating cardio-cerebrovascular disease.
The Solyx™SIS System is an innovative mid-urethral sling single incision system consisting of a 9 cm long polypropylene mesh, whose mid-urethral portion (4 cm) is detanged to potentially resist deformation and to reduce irritation to the urethral wall. Snap-fit to delivery device tip allows for advanced placement control and, therefore, the tensioning through the forward and reverse functions performed with this delivery device.