anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Malalignment prevents proper transmission of forces across the knee leading to advance or even start the progression of osteoarthritis.Preoperative planning is necessary to identify the level and magnitude of the deformity. Corrections can be performed acutely or gradually. Acute correction can be achieved by opening wedge, closing wedge or dome osteotomies followed by internal fixation. On the other hand, gradual correction can be achieved by osteotomy with external fixation.

Although osteotomy with internal fixation is more convenient to the patient than external fixator, it has many drawbacks. These include the need for large surgical exposure, soft tissue stripping and difficulty executing precise deformity correction. Meticulous preoperative planning is important when internal fixation is planed. It also needs to be executed precisely till fixation is completed. Under-correction or over-correction is possible while executing the procedure. Furthermore, iatrogenic deformity in other planes may also develop. If such a deformity is significant, it may adversely affect the function or may lead to excessive loading on adjacent joints. In some cases, revision of surgery for further correction may be required to correct this residual or iatrogenic deformity.

External fixation can be used for gradual correction of genu varum. In spite of the disadvantages of external fixation like being uncomfortable for the patient, tethering soft tissue, associated pin site infection and irritation , it is re-adjustable postoperatively. This allows controlled accurate correction of the mechanical axis of the lower limb.

Our study is implicated on correction of high degree genu varum which is more than 20 degrees .To correct such deformity, it is difficult to calculate the amount of wedge opening intraoperative. The described trigonometric calculation of the size of the base is described for deformity less than 20 degrees .In this study we are going to use a hybrid technique of both external and internal fixation, so we can make use of the benefits of both internal and external fixation techniques External fixation by limb reconstruction system (LRS) or Taylor Spatial frame(TSF) is used to control and stabilize fragments while performing the desired correction. A locked T plate is then applied to stabilize the fully corrected osteotomy. This allows intraoperative removal of the external fixator without loss of correction. Then we compare the planned correction with the achieved correction.
Hypnobirthing is a birth philosophy and method that prepares women physically and psychologically for giving birth. It is important to break the fear-tension-pain cycle in HypnoBirthing training. Because the continuity of the cycle increases the pain related to birth, and as the pain increases, the fear increases. In this case, the duration of labor is prolonged, birth success, shape, preference, course and satisfaction are negatively affected. Therefore, this training helps to reduce pain and fear related to labor and increase labor satisfaction. Similarly, it has been determined in the literature that oxytocin (back massage) massage during pregnancy increases uterine contractions, reduces labor pain and duration of labor, accelerates postpartum uterine involution, significantly increases the amount of breast milk, and increases mother-baby attachment. The pregnant education role of the health professional is an effective factor that shapes the birth experience of pregnant women. For this purpose, health professionals in the world and in our country are actively involved in pregnancy education programs in which different methods are applied. The most common ones are Lamaze, Bradly and HypnoBirthing. These trainings also serve to reduce pain and fear related to childbirth, increase labor and postpartum satisfaction, and meet the need for professional support and education of pregnant women. When the studies on HypnoBirthing training and oxytocin massage are examined in the literature, it is noteworthy that there is a very limited number of studies. Therefore, there is a need for well-designed randomized controlled trials that can create a level of evidence for HypnoBirthing training and oxytocin massage.
The methods shall be applied in dentistry, restorative procedures and research. It performs an intraoral scan of the patient's teeth at intervals in time. Computed tomography (CBCT) of the patient's mouth is also performed and a patient file is created from the images from each scan. They are saved and used for subsequent restoration of dental status. The first scanning (3, 3n) for the patient (2, 2n) file (4, 4n) by intraoral scanner is at the occlusion of the first permanent teeth, and the computed tomography (CBCT) imaging (6, 6n) is determined individually. This creates the maxillofacial oral status of each patient by adding to his file a photo image (7, 7n) of the face , as all files (4, 4n) are saved in a database for the oral and maxillofacial status (5). From the images from the intraoral scanner, CBCT and the photo image are made combined images (8, 8n) as well as intermediate images, representing overlapping of selected images by at least one of the means used - the intraoral scanner, CBCT and camera. By means of the images the maxillofacial status database (5) is updated and supported. The database (5), besides (A) restoration of dental status, can be used for at least one of following: (B) diagnosis of other diseases, (C) making dental veneers, (D) creating dental forms marketing (E) identification of natural persons (E) research. According to the created method for making dental veneers using the database for the maxillofacial status, whereby a 3D image of the patient's teeth is downloaded from the database in its entirety, after which the dentin and tooth enamel parts of each tooth are printed separately on a 3D printer (10), thus obtaining two components, which are glued with a composite mediator, and then is made an occlusal splint for the teeth in the dentition and an occlusal register is printed out.
The invention discloses a gram-positive bacterium resistant compound derived from polar region source fungi, and a preparation method and application thereof. The gram-positive bacteria resistant compound is derived from polar origin fungi, namely Neonectria sp (Neonectria sp.) CPCC401225, and the registration number of the gram-positive bacteria resistant compound in the China general microbiological culture Collection center is CGMCC No. 20277. The invention separates the enniatins compound (Enniantins) with better anti-gram-positive bacteria activity from the Neonectria fungi for the first time. The compound shown in the formula I, II or III has a simple preparation process, and is suitable for researching an anti-gram-positive bacteria lead compound or preparing an anti-gram-positive bacteria medicament.
The use of exercise as an adjunct to other disease modifying treatments in MS has found increasing support over the past decade. There is ample evidence that exercise therapy can improve physical measures of disability in MS, in addition to being safe and well-tolerated. However, there is a paucity of data on whether exercise is equally effective for those with primary progressive MS as it is in relapsing remitting MS. In addition, studies of exercise therapy have traditionally excluded MS patients with severe disability. There are also currently no treatments for primary progressive MS, so finding a safe disease-modifying therapy is of the utmost importance. The investigators are therefore conducting a pilot trial to evaluate the effects of exercise in the form of supported treadmill walking for patients with primary progressive MS with severe functional impairments.

Six patients with primary progressive MS with high disability level will be recruited to participate in this study. Participants will exercise using body-weight supported treadmill training (BWSTT; Woodway Loco-system) which allows a portion of an individual's body-weight to be counterbalanced by an overhead pulley system. This system allows patients with limited mobility to walk upright on the treadmill with therapist assistance. Therapists trained in using the BWSTT system will guide the patients' legs through a proper gait motion and assist with lower limb control. Participants will complete 72 training sessions (30min/session, 3x/week) over the course of 24 weeks. Participants will be evaluated at baseline, 12 weeks (half-way through the training program) and 24 weeks (end of intervention). A follow-up assessment will also be performed 12 after participants have completed the training program (36 weeks). Outcome measures are described below.
One aspect of the invention is to provide humanized antibodies specific for VZV gpIII. Another aspect of the invention is to provide polynucleotides encoding humanized antibodies specific for VZV gpIII. Various expression vectors comprising polynucleotides encoding humanized VZV gpIII specific antibodies joined to promoter sequences are also provided. Similarly, another aspect of the invention is host cells transformed with expression vectors for the expression of humanized antibodies specific for VZV gpIII. Another aspect of the invention is to provide humanized anti-VZV gpIII antibodies that are labeled with a detectable label or a therapeutic label. Another aspect of the invention is to provide methods for treating, preventing or diagnosing, varicella zoster infections by administering a composition comprising a humanized VZV gpIII specific antibody. The invention also provides methods for the detection of VZV particles in samples for analysis, e.g., blood.
It is not known if fexofenadine is excreted in human milk. Because many drugs are excreted in human milk, caution should be used when fexofenadine hydrochloride is administered to a nursing woman. Pseudoephedrine hydrochloride administered alone distributes into breast milk of lactating human females. Pseudoephedrine concentrations in milk are consistently higher than those in plasma. The total amount of drug in milk as judged by AUC is 2 to 3 times greater than the plasma AUC. The fraction of a pseudoephedrine dose excreted in milk is estimated to be 0.4% to 0.7%. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Caution should be exercised when ALLEGRA-D 12 HOUR is administered to nursing women.
BACKGROUND: Human papillomavirus (HPV) can cause cancers in men and women. Despite the availability of an effective vaccine, HPV vaccination coverage remains suboptimal among college students. Literature showed that hesitancy for HPV vaccination is a leading barrier to the uptake in this group. However, prior interventions have shown limitations in reducing HPV vaccine hesitancy in college students. Thus, this study examined a conventional educational approach using a vaccine information statement (VIS), and subsequently explored college students' HPV vaccine hesitancy and the potential of virtual reality (VR) technology to overcoming the limitations of interventional efforts.
METHODS: We employed a mixed-methods design along with convenience sampling, constituting a one-way pre- and post-intervention (HPV VIS) survey (Study A) and individual interviews (Study B). All data collections occurred with 44 college students at an urban public university at the mid-south region of the U.S. between October 2022 and April 2023. Study A assessed changes in HPV vaccination outcomes including knowledge, beliefs/attitudes, vaccine hesitancy, and intentions. Study B measured college students' primary reasons for HPV vaccine hesitancy and preferred strategies for the vaccination promotion including VR-based education. We conducted paired t-test and Wilcoxon signed ranks test for quantitative data and framework analysis for qualitative data.
RESULTS: Participants reported significant improvements in knowledge [t(43) = 6.68, p < 0.001] regarding HPV vaccination between before and after reading the HPV VIS. No change was observed in beliefs/attitudes, vaccine hesitancy, and intentions. The framework analysis revealed college students' reasons for HPV vaccine hesitancy, needed information, and preferred strategies along with the potential of VR technology for future HPV vaccination education.
CONCLUSION: The findings provided essential information on designing HPV vaccination information focused on vaccine hesitancy among college students. Future research should consider these findings in developing interventions including VR to increasing HPV vaccine acceptance among college students.
A diagnostic kit, such as a medical self-test kit, is packed into packaging bearing an identifier, such as a two-dimensional code or barcode. The identifier is linked to stored personal data of a person to whom the diagnostic kit is to be delivered. When a fulfilment entity such as a courier scans the identifier, they are given access only to delivery details within the stored personal data, such as the person’s name and address. The privacy of other stored personal data, such as a test request record or diagnostic results, is therefore preserved. Scanning the identifier may provide only one-time access to the delivery details. The identifier may be linked to the personal data via an order identifier created prior to scanning the identifier. The diagnostic kit may have a kit identifier linked to the order identifier and a lot number, stock keeping unit, expiry date, manufacturing date, product name, manufacturer, specification, or instructions. Diagnostic data may be linked to the order identifier by scanning the kit identifier. Only a controller of a system for ordering the diagnostic kits may use the kit identifier to access the personal data or diagnostic data. Other entities may obtain authorisation from the controller.
BACKGROUND: Depression is a life-threatening mental health problem. Various factors have been demonstrated to be associated with depressive symptoms, including negative life events (NLEs) and alexithymia. A retrospective study was conducted to investigate the relationship among negative life events, alexithymia, and depression symptoms in a psychosomatic outpatient sample in China.
METHODS: A total of 2747 outpatients (aged 18 - 65) were included in this investigation. The Life Events Scale (LES), Toronto alexithymia scale (TAS-26), and 9-item Patient Health Questionnaire (PHQ-9) were used to assess NLEs, alexithymia, and depressive symptoms, respectively. A stepwise regression analysis model was established to investigate the relationship among alexithymia, NLEs, and depressive symptoms.
RESULTS: Overall, 67.0% of the patient sample had a PHQ-9 score of 10 or higher. The stepwise regression analysis model showed a well-fitted model, in which NLEs and alexithymia explain a total of 34.2% of the variance of depressive symptoms in these participants. NLEs (β = 0.256, p < 0.001) and dimensions of alexithymia (difficult describing feelings (β = 0.192, p < 0.001) and identifying feelings (β = 0.308, p < 0.001)) were positively correlated with symptoms of depression.
CONCLUSIONS: Previous studies have confirmed the correlation between NLEs and depression, alexithymia and depression, respectively. In our study, we used a stepwise regression model to explain the relationship among those variables simultaneously, and found that NLEs and alexithymia could function as predictors of depressive symptoms. Based on this discovery, alexithymia-focused treatment strategies could be alternative in depressive patients with alexithymia, but this remains to be verified in the future.
The safety and efficacy of filgrastim to decrease the incidence of infection‚ as manifested by febrile neutropenia‚ in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs were established in a randomized‚ double-blind‚ placebo-controlled trial conducted in patients with small cell lung cancer (Study 1).

In Study 1, patients received up to 6 cycles of intravenous chemotherapy including intravenous cyclophosphamide and doxorubicin on day 1; and etoposide on days 1, 2, and 3 of 21 day cycles. Patients were randomized to receive filgrastim (n=99) at a dose of 230 mcg/m2 (4 to 8 mcg/kg/day) or placebo (n=111). Study drug was administered subcutaneously daily beginning on day 4, for a maximum of 14 days. A total of 210 patients were evaluable for efficacy and 207 were evaluable for safety. The demographic and disease characteristics were balanced between arms with a median age of 62 (range 31 to 80) years; 64% males; 89% Caucasian; 72% extensive disease and 28% limited disease.

The main efficacy endpoint was the incidence of febrile neutropenia. Febrile neutropenia was defined as an ANC < 1,000/mm3 and temperature > 38.2°C. Treatment with filgrastim resulted in a clinically and statistically significant reduction in the incidence of infection‚ as manifested by febrile neutropenia, 40% for filgrastim-treated patients and 76% for placebo-treated patients (p < 0.001). There were also statistically significant reductions in the incidence and overall duration of infection manifested by febrile neutropenia; the incidence, severity and duration of severe neutropenia (ANC < 500/mm3); the incidence and overall duration of hospital admissions; and the number of reported days of antibiotic use.
A gastrointestinal tract ultrasonic examination contrast agent and a preparation method therefor, belonging to the technical field of medical imaging diagnosis. The contrast agent mainly consists of a thickening agent, an osmotic pressure regulator, a solid contrast substance, a defoaming agent and a flavoring agent, wherein the density of the solid contrast substance is the same as that of the contrast agent solution. Use of a solid contrast substance having a specific particle size enables the contrast agent to reach the stomach and intestines, providing for a more pronounced and homogeneous high-echo in the distribution area and achieving an excellent contrast effect. Because of the temperature sensitivity of the contrast agent, the viscosity thereof is low at normal temperature and high at 37˚C. When the contrast agent first reaches the stomach and intestines, the temperature is low, and the low viscosity is conducive to gas displacement, reducing artifacts caused by gas. After the contrast agent has been in the stomach and intestines for a certain period of time, the temperature rises to body temperature and the viscosity increases, prolonging the gastrointestinal examination window and ensuring ample examination time. The contrast agent is intended to solve the problem of the examination window being short when viscosity is too low, and the problem of being unable to remove gas artifacts when viscosity is too high. The contrast agent thus has excellent application prospects.
OBJECTIVES: The aim of this study was to develop the Lithuanian version of the Pediatric Voice Handicap Index (pVHI) and to assess its psychometric characteristics.
METHODS: The Lithuanian version of the pVHI was prepared according to the standard requirements for the questionnaire translation and adaptation procedure. It also included forward and backward translations of the original questionnaire, as well as a committee review and psychometric testing of the final version of the pVHI. A total of 126 children between 4 and 13 years of age were included in the study. Two study groups were formed: a group consisting of children with dysphonia (n = 70) and a control group of children without any alterations in their voice (n = 56). The questionnaire was always completed by their parents. The results were statistically analysed to assess the reliability, validity, sensitivity and specificity of the Lithuanian version of the pVHI.
RESULTS: High internal consistency of the Lithuanian version of the pVHI was determined (Cronbach's α = 0.938). The test-retest analysis also showed a high correlation between the two tests (r = 0.949) for both the dysphonic and control groups. The mean overall pVHI score was significantly higher (P < 0.001) in the dysphonic group than in the control group: 26.16 ± 11.84 and 2.43 ± 2.61, respectively. Similar results were obtained for all domains of pVHI. The most sensitive and specific limiting value for discrimination between the clinical and control groups was the sum of 8 points.
CONCLUSIONS: The Lithuanian version of the pVHI is a reliable and valid instrument for the evaluation of the Voice Handicap Index in the pediatric population and can be easily applied in daily clinical practice.
Women with a self-reported pre-pregnancy BMI of 28 or more will be eligible for our study. Woman are eligible if they are 18 years or older, with a singleton live fetus at an early (week 12-14) ultrasound scan. Exclusion criteria are pregnancy complications with high risk for preterm labour or diseases that could interfere with participation.

Primary outcome measure is weight increase based on weight measured at 14 weeks and immediately before labour. Assessments are done at baseline at 14 (12-18) weeks of pregnancy, and again in week 38, as well as 3 months postpartum. Some measurements are also done at other points in time. The maternal secondary outcome measurements include fasting glucose, glucose tolerance assessed by 2-h, 75 mg per-oral glucose tolerance test, insulin resistance assessed by HOMA-IR, weight, height, body composition estimated by skinfold measurements in pregnancy and by dual energy x-ray absorptiometry postpartum, blood markers, lumbopelvic pain, urin- and fecal incontinence, quality of life, psychological wellbeing, depression, and diet.
The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein. However, the biological function and mechanism of ZNF706 have been poorly investigated. Clinically, ZNF706 expression was elevated in hepatocellular carcinoma (HCC), and high ZNF706 expression was associated with unfavorable survival in HCC patients. Functional experiments revealed that ZNF706 knockdown inhibited HCC progression both in vitro and in vivo. RNA sequencing (RNA-seq) and chromatin immunoprecipitation-based deep sequencing (ChIP-seq) revealed that mechanistically, ZNF706 is a crucial ferroptosis regulator and that SLC7A11 is a critical target of ZNF706. In addition, ZNF706 knockdown inhibited SLC7A11 expression, increased lipid peroxidation, and promoted ferroptosis. Further analysis revealed that ZNF706 is a novel direct target transcriptionally activated by MYC in HCC cells. Importantly, MYC depletion reduced SLC7A11-mediated redox homeostasis, and this effect was reversed by ZNF706 reexpression. Collectively, our data demonstrate that ZNF706 is a potential oncogene in liver cancer and functions as a ferroptosis regulator by modulating SLC7A11 expression, constituting a potential therapeutic target for HCC.
(SEE BOX WARNING.)Succinylcholine should be administered with GREAT CAUTIONto patients suffering from electrolyte abnormalities and those who may have massive digitalis toxicity, because in these circumstances succinylcholine may induce serious cardiac arrhythmias or cardiac arrest due to hyperkalemia. 

GREAT CAUTIONshould be observed if succinylcholine is administered to patients during the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury (see CONTRAINDICATIONS). The risk of hyperkalemia in these patients increases over time and usually peaks at 7 to 10 days after the injury. The risk is dependent on the extent and location of the injury. The precise time of onset and the duration of the risk period are undetermined. Patients with chronic abdominal infection, subarachnoid hemorrhage, or conditions causing degeneration of central and peripheral nervous systems should receive succinylcholine with GREAT CAUTIONbecause of the potential for developing severe hyperkalemia.