anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a randomized, crossover, pilot study that includes two screening visits and two 4-week test periods, separated by a 3-week washout. Subjects will consume study products providing 4 tablespoons oil/day of either corn oil or coconut oil replacing the same amount of oil in the background diet. Subjects will otherwise be encouraged to follow their habitual diet during both treatment periods. They will receive diet instructions on the incorporation of food substitutions during the test periods to maintain habitual energy intake. Subjects will record daily study product intake and compliance in a Daily Log. An intravenous glucose tolerance test (IVGTT) will be completed at baseline and the end of each treatment period for evaluation of insulin sensitivity. Fasting blood samples will be collected for lipid profile and high-sensitivity C-reactive protein (hs-CRP) measurements at all visits. Assessments of vital signs and body weight, review of concomitant medication/supplement use and inclusion and exclusion criteria for relevant changes, and evaluation of adverse effects will be performed throughout the study. Compliance will be assessed using the Daily Log intake percentages as the primary source.
For participants with HbA1c ≥ 7.5%, Community Scientists will offer enrollment in existing SDRI diabetes education programs and will schedule a follow-up contact for 3 and 6 months later for repeat testing. Study participation for each participant will end upon completion of 6 month follow up.
FIELD: chemistry.SUBSTANCE: disclosed workpiece contains lithium silicate crystals in amount of more than 10 vol. %, wherein blank consists of glass ceramics with density between 30 % and 60 % of theoretical density of sintered workpiece and with fraction of lithium silicate crystals, which is from more than 10 vol. % to 90 vol. %, with pores value of 0.1 mcm to 5 mcm, and is made by pressing particles of crystallized glass-ceramic powder with composition, wt. %: SiO46.0–72.0, LiO 10.0–25.0, ZrO6.5–14.0, PO1.0–10.0, AlO0.1–8.0, KO 0.1–5.0, CeO0.1–4.0, BO0.0–4.0, NaO 0.0–4.0, TbO7 0.0–2.5, as well as 0.0 to 4.0 at least one additive and with grain size distribution d≤ 80 mcm and d≤ 25 mcm. Method of making said dental molded part includes steps of: making a melt with said composition; making glass frit by melt spraying and rapid cooling in medium; crystallisation of lithium silicate crystals with volume fraction between 10 % and 90 % using first heat treatment or glass frit, or particles of glass powder made from glass frit with grain size distribution d ≤ 80 mcm and d ≤ 25 mcm in first temperature range at temperature Tunder condition of 500 °C ≤ T ≤ 750 °C, for a time tprovided 5 min ≤ t≤ 120 min; wherein, if glass frit is subjected to thermal treatment, particles of glass-ceramic powder with grain size distribution d are made from glass frit subjected to thermal treatment d≤ 80 mcm and d≤ 25 mcm; pressing the glass-ceramic powder particles to form a billet with density between 30 % and 60 % of the theoretical density of the sintered workpiece and a pore value of 0.1 mcm to 5 mcm; processing the workpiece by milling to produce a semi-finished product corresponding to the dental molded part, taking into account the shrinkage characteristics of the workpiece, and semifinished product sintering at temperature Tunder condition 800 °C ≤ T≤ 1050 °C, for a time tprovided 5 min ≤ t≤ 60 min. Disclosed also is a monolithic dental molded part (insert, pad, crown or bridge) made by said method and/or using said billet. Dental molded part with thin walls can be made with good mechanical properties. Tool wear during machining is negligible.EFFECT: group of inventions relates to a workpiece for making a dental molded part, such as an insert, an overlay, a crown or a bridge, as well as a corresponding dental molded part and a method for production thereof.25 cl, 3 ex, 1 dwg
Diabetes mellitus (DM) is a chronic disease characterized by the human body's inability to maintain appropriate blood glucose levels ( Buse et al. 2011). When inadequately managed, diabetes results in poor glycemic control, which, if prolonged, results in diabetes-related complications (Stratton et al. 2000). Diabetes is the major cause of blindness, kidney failure, and non-traumatic amputation in Canadian adults (PHAC, 2011). Foot ulcers are the major causes of amputations. Foot ulcers arise from poor circulation associated with peripheral vascular disease and neuropathy, injury and infections. Diabetes affects circulation and immunity, and over time the sensory nerves in the hands and feet may be damaged.

There are more than 2.4 million Canadians living with diabetes, of which 1.2 million of them live in Ontario (MHLTC). Diabetes is the leading cause of non-traumatic lower limb amputation in Canadian adults, associated with approximately 70% of amputations performed in hospital. Compared to the general population, Canadian adults with diabetes are over 20 times more likely to undergo non-traumatic lower limb amputations, 85% of which are preceded by a foot ulcer (PHAC, 2011 and Singh et al.,2005). According to a recent report (CDA, 2016) commissioned by the Canadian Diabetes Association (CDA), of the 1.53 million people with diabetes in Ontario, between 16,600 and 27,600 were expected to have a diabetes foot ulcer in 2015. Of these, nearly 2,000 were expected to need to have a lower limb amputated as a result of their condition and those amputations are associated with almost 800 premature deaths. In Ontario, diabetic foot ulcers (DFU) currently impose direct health-care costs of between $320-400 million and indirect costs of between $35-60 million (Hopkins et al.,2015).

Strong evidence shows that up to 85% of diabetic foot amputations can be prevented, supporting the benefits of early recognition of diabetes-related foot complications (CDA, 2013). Furthermore, timely assessment, referral, and provision of evidence-informed foot care are cost saving for the healthcare system. Use of a standardized diabetic foot assessment tool is required to ensure consistent approach to risk recognition and provide a framework for care. In response to the need for a tool that facilitates a consistent and standard screening procedure, the Primary Care Diabetes Support Program (PCDSP) at St. Joseph's Health Care, London, Ontario developed an evidence based, multi-disciplinary foot ulcer assessment tool. The SJHC harmonized foot ulcer assessment tool was developed to aid in the early detection of diabetic foot problems and to ensure prompt referral to the right foot care provider for appropriate treatment, thereby improving outcomes of the diabetic foot.
Balanced fluids (BF), including Lactated Ringer's and Plasma-Lyte (PL), will be administered to patients randomized to the experimental arm. BF will be used for all fluid boluses and maintenance fluids (supplemental electrolytes are allowed) from time immediately after randomization through 11:59 pm of the next calendar day. The determination of when to give fluid, how much fluid to give, how fast to give fluid, and what access to use to administer fluid will remain at the discretion of the treating team.
The gut-brain axis is a bidirectional communication network linking the gut and the brain, overseeing digestive functions, emotional responses, body immunity, brain development, and overall health. Substantial research highlights a connection between disruptions of the gut-brain axis and various psychiatric and neurological conditions, including depression and Alzheimer's disease. Given the impact of the gut-brain axis on behavior, cognition, and brain diseases, some studies have started to pay attention to the role of the axis in sepsis-associated encephalopathy (SAE), where cognitive impairment is the primary manifestation. SAE emerges as the primary and earliest form of organ dysfunction following sepsis, potentially leading to acute cognitive impairment and long-term cognitive decline in patients. Notably, the neuronal damage in SAE does not stem directly from the central nervous system (CNS) infection but rather from an infection occurring outside the brain. The gut-brain axis is posited as a pivotal factor in this process. This review will delve into the gut-brain axis, exploring four crucial pathways through which inflammatory signals are transmitted and elevate the incidence of SAE. These pathways encompass the vagus nerve pathway, the neuroendocrine pathway involving the hypothalamic-pituitary-adrenal (HPA) axis and serotonin (5-HT) regulation, the neuroimmune pathway, and the microbial regulation. These pathways can operate independently or collaboratively on the CNS to modulate brain activity. Understanding how the gut affects and regulates the CNS could offer the potential to identify novel targets for preventing and treating this condition, ultimately enhancing the prognosis for individuals with SAE.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to neonatology, and can be used in treatment of newborns who are on ILV in critical state, conditioned by perinatal affection of central nervous system. For this purpose preliminarily rate of blood flow in vein of Galen is determined by dopplerography. If rate of blood flow decreases lower than 4 cm/s, inhalation with nitrogen oxide in concentration 15 ppm during 24 hours is carried out. ^ EFFECT: method allows to considerably reduce lethality of newborns in case of said pathology due to respiratory therapy with nitrogen oxide which is endothelial relaxing factor, and in case of introduction through inhalation - selective pulmonary vasodilatator. ^ 3 ex
The patients will receive bilateral posterior quadratus lumborum block using 0.125% bupivacaine 0.4 ml/kg. in each side.
A method is disclosed for post-processing of a  3 D image data record which has been recorded by way of an imaging tomographic appliance of a body area, and covers at least one hollow organ which is at least partially filled with contrast agent. An imaging apparatus is also disclosed. In the method, an automatic three-dimensional edge detection process is carried out in the  3 D image data record in order to determine transitions between areas which have contrast agent and a wall of the hollow organ as boundary surfaces. A weighted high-pass filtering process is carried out at right angles to the boundary surfaces and leads to removal of the areas which have contrast agent and in which process areas around the transitions are given a lower weighting than areas which are further away from the transitions. After low-pass filtering in the areas around the transitions, a  3 D image data record is produced from which the areas which are filled with contrast agent are eliminated, without image artifacts being produced at the transitions to the wall of the hollow organ. The method can be used in particular for virtual bowel cleaning in virtual colonography.
Methods and devices useful for monitoring a patient and for monitoring and displaying the value of a physiological parameter are disclosed. In one embodiment, a user interface for a medical monitoring device is provided. The user interface can have a monitoring screen with a current value screen and a trend screen. The current value screen can displaying a graphical representation of a value of a physiological parameter over time, e.g., over a current time period, and the trend screen can display a graphical representation of a mean value of the physiological parameter over time, e.g., over a historical time period. The time periods can be adjustable. In some embodiments, an out-of-limit condition for the physiological parameter can be indicated with shading. For example, the current value screen can display shading between a trendline representing the value of the physiological parameter and a threshold line, which sets the alarm threshold. The historical value screen can display shading between a trendline representing the value of the physiological parameter and another threshold line. In yet other embodiments, the user interface can provide an event marking screen. The event marking screen can provide the ability to mark events, e.g., delivery of a drug to the patient, adjustment of a sensor, and so on, on a historical trend screen that displays a value of the physiological parameter over time. Such event marking can enable a caregiver to correlate events to a change in a patient's condition as manifested by the physiological parameter.
Metformin hydrochloride extended-release tablets, USP contain the biguanidine antihyperglycemic agent, metformin, in the form of monohydrochloride salt. The chemical name of metformin hydrochloride is 1,1-Dimethybiguanide monohydrochloride with a molecular formula of C4H11N5•HCl and a molecular weight of 165.6. Its structural formula is:

Metformin hydrochloride, USP is a white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochloride is 6.68. 

Metformin hydrochloride extended-release tablets deliver 500 mg or 1000 mg of metformin hydrochloride. In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: cellulose acetate, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, povidone, red iron oxide, sodium lauryl sulfate, talc, titanium dioxide, triacetin, triethyl citrate and yellow iron oxide. In addition, the black imprinting ink contains ammonium hydroxide, black iron oxide, propylene glycol and shellac glaze.

Meets USP Dissolution Test 5.
A method for operating a computer system to generate and display multidimensional data. A set of multidimensional data points and a selected deviation range is received at a processor. The processor processes each data point to determine its value about the selected deviation range. Display data representative of data point indicia of the determined data point values at circumferentially spaced locations and with respect to an origin in a coordinate system is generated and stored by the processor. The data point indicia for the multidimensional data points are at circumferentially spaced locations, and a radial distance of the indicia with respect to the origin represents the determined data point values. A visual display of the display data can be produced on a printer or monitor.
BACKGROUND: Unraveling gene-environment interaction can provide a novel insight into early disease prevention. Nevertheless, current understanding of the interplay between genetic predisposition and air pollution in relation to myocardial infarction (MI) risk remains limited. Furthermore, the potential long-term influence of air pollutants on MI incidence risk warrants more conclusive evidence in a community population.
OBJECTIVE: We investigated interactions between genetic predisposition and exposure to air pollutants on MI incidence.
METHODS: This study incorporated a sample of 456,354 UK Biobank participants and annual mean air pollution (PM2.5, PM10, NO2, and NOx) from the UK Department for Environment, Food and Rural Affairs (2006-2021). The Cox proportional hazards model was employed to explore MI incidence after chronic air pollutants exposure. By quantifying genetic risk through the calculation of polygenic risk score (PRS), this study further examined the interactions between genetic risk and exposure to air pollutants in the development of MI on both additive and multiplicative scales.
RESULTS: Among 456,354 participants, 9,114 incident MI events were observed during a median follow-up of 12.08 y. Chronic exposure to air pollutants was linked with an increased risk of MI occurrence. Specifically, the hazard ratios (per interquartile range) were 1.12 (95% CI: 1.10, 1.13) for PM2.5, 1.20 (95% CI: 1.19, 1.22) for PM10, 1.13 (95% CI: 1.12, 1.15) for NO2, and 1.12 (95% CI: 1.11, 1.13) for NOx. In terms of the joint effects, participants with high PRS and high level of air pollution exposure exhibited the greatest risk of MI among all study participants (∼255% to 324%). Remarkably, both multiplicative and additive interactions were detected in the ambient air pollutants exposure and genetic risk on the incidence of MI.
DISCUSSION: There were interactions between exposure to ambient air pollutants and genetic susceptibility on the risk of MI onset. Moreover, the joint effects of these two exposures were greater than the effect of each factor alone. https://doi.org/10.1289/EHP14291.
PURPOSE:To uniformly distribute an extract of licorice with water into live bait by mixing 1 pt.wt. water extract of licorice with 20-100 pts.wt. powder capable of mixing into feed of fishes. CONSTITUTION:Extraction of licorice with water is performed by adding water in an amount of about 5-15 times of licorice to crushed or finely cut root or rhizome of licorice and heated or allowed to stand at normal temperature. Resultant extract solution is concentrated and dried to obtain a brown powdery extract, then said brown extract is directly used as licorice formulation. Powder mixing with water extract of licorice is usable unless harmful for the growth of fishes. Beer yeast, wheat flour, dextrin, milk sugar, brown meal or white meal, etc., is exemplified. The mixing is sufficiently performed till a uniform mixture is formed by using a suitable mixer, etc. The necessary amount of the licorice formulation is calculated as a suitable amount to be taken by fish according to the intaked amount of feed by fish and mixed with bait raw material when the bait is prepared.
The prevalence of chronic kidney disease (CKD) is highly increasing. Renal fibrosis is a common pathological feature in various CKD. Previous studies showed tubular cell senescence is highly involved in the pathogenesis of renal fibrosis. However, the inducers of tubular senescence and the underlying mechanisms have not been fully investigated. C-X-C motif chemokine receptor 4 (CXCR4), a G-protein-coupled seven-span transmembrane receptor, increases renal fibrosis and plays an important role in tubular cell injury. Whereas, whether CXCR4 could induce tubular cell senescence and the detailed mechanisms have not studied yet. In this study, we adopted adriamycin nephropathy and 5/6 nephrectomy models, and cultured tubular cell line. Overexpression or knockdown of CXCR4 was obtained by injection of related plasmids. We identified CXCR4 increased in injury tubular cells. CXCR4 was expressed predominantly in renal tubular epithelial cells and co-localized with adipose differentiation-related protein (ADRP) as well as the senescence-related protein P16INK4A . Furthermore, we found overexpression of CXCR4 greatly induced the activation of β-catenin, while knockdown of CXCR4 inhibited it. We also found that CXCR4 inhibited fatty acid oxidation and triggered lipid deposition in tubular cells. To inhibit β-catenin by ICG-001, an inhibitor of β-catenin, could significantly block CXCR4-suppressed fatty acid oxidation. Taken together, our results indicate that CXCR4 is a key mediator in tubular cell senescence and renal fibrosis. CXCR4 promotes tubular cell senescence and renal fibrosis by inducing β-catenin and inhibiting fatty acid metabolism. Our findings provide a new theory for tubular cell injury in renal fibrosis.
This study is a randomized, therapy-controlled trial in a primary care setting at a university hospital. Patients presenting to our outpatient clinic with initial symptoms of coxarthrosis will be assessed against inclusion and exclusion criteria. After patient consent, 6 weeks of treatment will ensue. During the six weeks of treatment, patients will receive one of two treatments, conventional physiotherapy or whole-body-vibration exercises of one hour three times a week. Follow-up examinations will be performed immediately after treatment and after another 6 and 20 weeks, for a total study duration of 6 months. 20 patients will be included in each therapy group.
Background: Due to lack of clear symptoms, type 2 diabetes can remain undetected for many years. Our aim was to explore the capacity of Norwegian community pharmacies to identify people at high risk of developing type 2 diabetes and the impact of the risk assessment service on self-rated health.

Methods: Nineteen community pharmacies were randomly allocated to a diabetes risk test only- group or Haemoglobin A1c (HbA1c) -group were the participants with a high risk of developing type 2 diabetes also received a HbA1c-measurement. Two pharmacists at each pharmacy were trained to perform risk assessments and counselling. The pharmacists at the 11 HbA1c pharmacies were also trained in how to perform the HbA1c- measurement. During six months, pharmacy customers equal or above 45 years old, wishing to participate contacted the pharmacy staff. Participants completed a validated diabetes risk test and a background questionnaire including a validated instrument for self-rated health. In the risk test only-group, participants with a high risk of developing type 2 diabetes were referred to their general practitioner for follow-up, while in the HbA1c-group, participants with HbA1c ≥ 48 mmol/ mol (6.5%) were referred to their general practitioner.
FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to ophthalmology. Surgical treatment of proliferative diabetic retinopathy comprises three-port transciliary vitrectomy, discission of Vitreoschisis layers, epiretinal schwart (ES) and epiretinal membranes (ERM), membrane peeling with subsequent endolaser coagulation of retina and tamponade of vitreal cavity with a gas-air mixture. And after transciliary vitrectomy, 0.1 ml of the Vitreocontrast suspension are injected into the vitreous humor by using a 25 G cannula inserted into the vitreous humor cavity and directed to the macula zone. Discration of Vitreoschism layers, ES and ERM are performed over the macula area with endovitreal scissors, starting from the center towards the periphery. Multiple layer-by-layer contrasting is carried out by introducing a Vitreocontrast suspension and discration of these layers until the internal limiting membrane (ILM) is visualized. After that, membrane peeling of the ILM is carried out. Discission of remaining Vitreoschisis layers, ES and ERM is further performed, for this purpose, the guillotine endovitreal scissors area rests against the surface of the retina in the macula area and the scissors are moved towards the periphery, entering paramaculously under the ERM and ES, and trey are cut into 3–10 sectors, starting from the center. Free fragments of ERM and ES, facing the vitreous humor side, are further removed with vitreotom while maintaining the adhesion of the base of ERM and ES to the retina at its periphery. Surgery is completed with endolaser coagulation of the retina and a tamponade of the vitreal cavity with a gas-air mixture.EFFECT: method increases the visual function of the eye by reducing postoperative complications such as bleeding from the cleavage on the retina, traction retina detachment caused by incomplete removal of epiretinal membranes (ERM), epiretinal schwart (ES), vitreoschisis.1 cl, 2 ex
The composition for treating tumors is a natural tumor treatment made from plant extracts, animal secretions and essential oils. The composition includes a solid mixture which is taken with a liquid mixture. The solid mixture is a mixture of  Dorema ammoniacum , castoreum, myrrh,  Cistus creticus, Asarum europaeum , cucumber seed, Egyptian cucumber seed, pumpkin seed, watermelon seed, cantaloupe seed, psyllium husk,  Astragalus tragacanthus , mastic, and lump sugar. Each of these solid ingredients is ground separately and then purified through sifting, draining and smoothing. Once ground and purified, the solid powders are mixed together into a homogenous mixture. These solids are delivered to the patient in pill, capsule, powder, solution or serum injection form. Approximately 12 grams of the solid mixture is taken with approximately 250 mL of a liquid mixture of the essential oils of  Borago officinalis , fennel,  Trachyspermum ammi , and  Cichorium.