anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Carefully consider the potential benefits and risks of Fenoprofen and other treatment options before deciding to use Fenoprofen. Use lowest effective dosage for the shortest duration consistent with individual patient treatment goals [ see Warnings and Precautions (5) ].   
Fenoprofen may be administered with meals or with milk. Although the total amount absorbed is not affected, peak blood levels are delayed and diminished.   
Patients with rheumatoid arthritis generally seem to require larger doses of Fenoprofen calcium than do those with osteoarthritis. The smallest dose that yields acceptable control should be employed.   
Although improvement may be seen in a few days in many patients, an additional 2 to 3 weeks may be required to gauge the full benefits of therapy.
PURPOSE: Provided is a novel preparation of cumambrin A which is prepared by extracting Chrysanthenum boreale M. And a pharmaceutical composition for the treatment of hypertension is also provided, which comprises the extracted cumambrin A as an active ingredient. CONSTITUTION: The preparation method of cumambrin A represented by the formula is characterized by extracting the petals or leaves of Chrysanthenum boreale M. with any solvent of 3 to 5 polar index, and if necessary, repeating at least a few times the extracting step. The solvent comprises preferably chloroform or ethyl acetate. The obtained extract may be purified by a conventional purification method of organic physiological active substances. The pharmaceutical composition comprising cumambrin A as an active ingredient can be formulated into various formulation types using conventional carriers. The formulation can be administered orally or parenterally, such as intravenous or intragastric injection. A dosage of the formulation ranges from 1 to 10 mg/kg body weight per a day. The pharmaceutical composition can be formulated into a form of tablet, syrup or solution for injection.
Antiinflammatory and analgesic surgical dressings, which produce cool sensation to the skin, consist of 2 layers of materials; a layer of a water-insol. and water-absorbing resin and a layer of a drug-contg. adhesive.  Thus, an acrylic acid-starch copolymer is applied to a polyethylene unwoven sheet at 0.5g/100cm2, and the copolymer is sandwiched by covering with another polyethylene sheet.  This is laminated with 8 layer of an adhesive (1g/100cm2) prepd. by mixing polystyrene rubber 10, rosin 3, and liq. paraffin 15 parts at 140≰C in N2 and combining with Me salicylate 1.5, menthol 1.0, and camphor 1.0 parts.
The quest for noninvasive early markers for sensorineural hearing loss (SNHL) has yielded diverse measures of interest. However, comprehensive studies evaluating the test-retest reliability of multiple measures and stimuli within a single study are scarce, and a standardized clinical protocol for robust early markers of SNHL remains elusive. To address these gaps, this study explores the intra-subject variability of various potential electroencephalogram- (EEG-) biomarkers for cochlear synaptopathy (CS) and other SNHL-markers in the same individuals. Fifteen normal-hearing young adults underwent repeated measures of (extended high-frequency) pure-tone audiometry, speech-in-noise intelligibility, distortion-product otoacoustic emissions (DPOAEs), and auditory evoked potentials; comprising envelope following responses (EFR) and auditory brainstem responses (ABR). Results confirm high reliability in pure-tone audiometry, whereas the matrix sentence-test exhibited a significant learning effect. The reliability of DPOAEs varied across three evaluation methods, each employing distinct SNR-based criteria for DPOAE-datapoints. EFRs exhibited superior test-retest reliability compared to ABR-amplitudes. Our findings emphasize the need for careful interpretation of presumed noninvasive SNHL measures. While tonal-audiometry's robustness was corroborated, we observed a confounding learning effect in longitudinal speech audiometry. The variability in DPOAEs highlights the importance of consistent ear probe replacement and meticulous measurement techniques, indicating that DPOAE test-retest reliability is significantly compromised under less-than-ideal conditions. As potential EEG-biomarkers of CS, EFRs are preferred over ABR-amplitudes based on the current study results.
This research was conducted as a randomised, controlled and quasi-experimental study to determine the effect of the training and telephone follow-up provided to the TB patients and contacts on the treatment adherence. The population of the study was composed of the patients receiving treatment in a tuberculosis control dispensary between July 2018-July 2019. The sample size was calculated to be 28 in each group through power analysis. Eighty-one TB patients and 90 TB contacts were included in the study. However, 15 TB patients and 3 contacts were excluded since they were transferred to another dispensary and they died. The study was completed with 66 TB patients in the intervention (n= 32) and control groups (n=34) and 87 contacts in the intervention (n= 41) and control groups (n = 46) The TB patients who applied to the dispensary and their contacts were informed about the aim and scope of the study. Then, four groups were formed by using the randomisation menu of the computer program: the intervention and control groups for the TB patients and the intervention and control groups for the contacts. The randomisation was conducted by a statistics specialist who had no contact with the participants. All participants were blinded to the randomisation procedure. However, the researchers were not blinded to the patient groups, due to the nature of the intervention.

The interviews were performed by using the face-to-face interview technique in the outpatient clinic. In the first interview, the questionnaire was applied to four groups; TB intervention and TB control group, Contact intervention and Contact control group.
PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition having excellent antitussive activity, by including anbroxol and at least one kind selected from chlorpheniramine, carbinoxamine and clemastine. SOLUTION: This composition comprises (A) at least one kind of compound selected from chlorpheniramine, carbinoxamine, clemastine and salts thereof, and (B) at least one kind of compound selected from ambroxol and salts thereof. Based on 1 pt.wt. of ambroxol, the amount of formulation of each compound is 0.01-0.5 pt.wt. (as d-chlorpheniramine) for chlorpheniramine, 0.02-1 pt.wt. for carbinoxamine, and 0.002-0.15 pt.wt. for clemastine. In order to improve the activity against the tussive reaction and affording excellent antitussive activity, the antitussive preparation representing 30-70 mg as ambroxol is orally administered to an adult for one day in its one or several divided doses.
All pediatric patients (ages 13-18) at Connecticut Children's Medical Center undergoing corrective scoliosis surgery for idiopathic scoliosis are eligible and will be approached for consent and inclusion into the study. This is a prospective pilot study, and all enrolled patients will receive a virtual reality (VR) intervention using a commercially available device manufactured by Oculus. The VR software will simulate a low physical load environment, such as an underwater space exploration game. Starting on postoperative day 1, the prospective cohort will undergo a 20-minute VR session 30 minutes prior to each physical therapy session. There will be two physical therapy sessions scheduled daily for the participant. Outcome measures will be assessed before and after the VR session and after the physical therapy session. The following procedures will continue daily until the participant is cleared for hospital discharge. A retrospective chart review will also be performed on patients with idiopathic scoliosis who have undergone corrective surgery to serve as a historical control for the study. The retrospective arm of the study only includes patients who have not received a VR intervention.
The definition use for reduced LV GLS will be \>-16%. An optimal threshold would also be calculated and derived from the pooled data.
INTRODUCTION: Occlusal and percussion pain may manifest occasionally following endodontic treatment, influencing retreatment decisions. Two cases of periapical neuropathic pain, classified as post-traumatic trigeminal neuropathic pain according to the International Classification of Orofacial Pain, are presented. Although mirogabalin is effective in managing neuropathic pain, there is a lack of clinical reports on its use for occasional post-traumatic trigeminal neuropathic pain after endodontic treatment. These cases highlight clinical symptoms and successful treatment with mirogabalin for post-traumatic trigeminal neuropathic pain after endodontic treatment, providing clinicians a "take-away" lesson for improving patient condition.
METHODS: The patients, referred by their primary dentist due to postendodontic abnormal pain, found no relief with antibiotics or nonsteroidal anti-inflammatory drugs. Although no findings including swelling or periapical radiolucency were observed around the tooth, they experienced occlusal and percussion pain. Local anesthetic testing showed that the pain originated from the peripheral area around the tooth rather than from central sensitization. Dental radiography and cone-beam computed tomography revealed no abnormal findings. Root canal retreatment was performed by a specialist in endodontic treatment. Although endodontic retreatment drastically decreased visual analog scale pain score, pain persisted. Based on the International Classification of Orofacial Pain criteria, diseases other than post-traumatic trigeminal neuropathic pain were excluded. Mirogabalin (10 mg/d) was prescribed once daily before bedtime.
RESULTS: Visual analog scale scores gradually and drastically decreased 2 weeks after mirogabalin therapy. Several months later, no recurrence of postendodontic pain was observed after tapering off and discontinuing mirogabalin.
CONCLUSIONS: These findings suggest the possibility of a new treatment method for post-traumatic trigeminal neuropathic pain after endodontic treatment.
BACKGROUND: Hemorrhoids are a common problem associated with symptoms, like swelling, local thrombosis and generally with a decreased quality of life, often in otherwise healthy subjects. Hemorrhoids can be classified by grades (I to IV) according to their severity. In this registry study subjects treated with excisional hemorrhoidectomy (EH) for the first time, were included. After surgery, edema tends to complicate surgical areas causing relevant symptoms. Most hemorrhoids symptoms are related to alterations in bowel habits. Increase in diet fibers to avoid constipation, exercise, and limiting straining reduce recurrence after surgery.
METHODS: The aim of the registry study was to evaluate the effects of Pycnogenol® (Horphag Research, Geneva, Switzerland) on relieving postoperative symptoms following hemorrhoidectomy. Pycnogenol® 150 mg/day was used between one month before surgery up to one month after surgery. The main postoperative symptoms were scored.
RESULTS: Thirty-eight subjects completed the 60-day supplement registry study. Eighteen subjects were supplemented with Pycnogenol® in addition to the standard management (SM) and 20 subjects only received SM and were considered as controls. The two groups were comparable for age, sex and main symptoms distribution and for their clinical characteristics at inclusion. No other disease was present. The scores for pain, discomfort, and constipation were significantly lower with the supplement compared to controls (P<0.05) 10 and 30 days after surgery. In addition, the quality-of-life score was higher with Pycnogenol® (P<0.05) while bleeding (minimal, not clinically evaluable) and a possible residual anal stenosis (requiring a longer period of observation) were barely observed. A satisfactory return to activity was observed 30 days after surgery in the 18 subjects using Pycnogenol®, and in only 15 out of 20 patients (75%) in the control group (P<0.05). All Pycnogenol® subjects were able to drive and perform daily tasks in comparison with 14 out of 20 subjects in the control group. The proportion of patients that took pain medication from day 10 to 30 post-surgery was significantly lower in the Pycnogenol® group than in controls (P<0.05).
CONCLUSIONS: In this post-surgical pilot, registry study, Pycnogenol® was effective in preventing and controlling postoperative symptoms after hemorrhoidectomy. To confirm the results, more cases are needed, including different surgical methods and clinical conditions. Mucosal and cutaneous edema and perianal swelling - generally seen after surgery - seem to be clearly reduced with Pycnogenol® and the supplement intake was associated with a more regular and pain-controlled convalescence and healing.
Inclusion compounds of bile acids and organic nitrates selected from glyceryl trinitrate, penta-erythritol tetranitrate, mannitol hexanitrate, erythritol tetranitrate and isosorbide dinitrate. Complexes are readily absorbed from the gastro-intestinal tract. The organic nitrates above are mainly used in treatment of angina pectoris. Solution of bile acid and organic nitrate in inert solvent which dissolves both. Product crystallises. Preferred molar ratio of nitrate:bile acid is 1:2. Desoxycholic acid (2.35 g.) and PETN (316 mg) were dissolved in 20 ml. of a 1:1 mixture of methanol and benzene with warming. The soln. was cooled to 0 deg.C and the crystals which separated were collected to give a PETN/desoxycholic acid complex with a ratio of 1:2. The mother liquors gave a mixture of inclusion compounds having a PETN/bile acid ratio of from 3:1 to 6:1.
The pathophysiology of immune thrombocytopenia (ITP) involves immune-mediated platelet destruction. The presence of adipose tissue in obese individuals creates an inflammatory environment that could potentially impact the clinical course and outcomes of ITP. However the relationship between obesity and ITP outcomes has not been well described. We evaluated ITP outcomes in 275 patients diagnosed with primary ITP from 2012 to 2022. Patients were categorized into four groups based on their body mass index (BMI) at diagnosis. Female gender was associated with a lower platelet count at the time of diagnosis at any BMI. Patients with high BMI had lower platelet counts at diagnosis and at platelet nadir (p < 0.001), an increased likelihood of requiring therapy (p < 0.001) and requiring multiple lines of therapy (p = 0.032). Non-obese patients who required corticosteroid treatment experienced a longer remission duration compared to obese patients (p = 0.009) and were less likely to be steroid-dependent (p = 0.048). Our findings suggest that obesity may be a significant risk factor for developing ITP and for ITP prognosis. Future studies are needed to evaluate the role of weight loss intervention in improving ITP outcomes.
Preterm infants have increased numbers of viral infections in childhood. They are also more likely to die from infection during the neonatal and infant periods than infants born at term. While studies have demonstrated that premature infants have decreased adaptive and innate immune responses compared with infants born at term, there has been little investigation into whether this impaired immunity improves and becomes similar to full term infants once the ex-preterm infants reach term-corrected gestational age. There have likewise not been studies to determine whether specific immune markers may predict the risk of developing sepsis. Given the immaturity of the preterm immune system and the many potential infectious and inflammatory insults they are exposed to during the preterm period (infections, poor nutrition, stress, steroid therapy), there is also a possibility that the relative immune deficiency experienced by preterm infants may persist into infancy.

The goal of this study is to determine whether former preterm infants have sustained differences in immunity compared to age-matched controls, which would have significant implications for infection risk and response to vaccination. Additionally, this study hopes to examine whether certain immune system abnormalities make certain babies more likely to have a serious infection. The present study will assess composition and function of T and B cell compartments in preterm and former preterm infants.
Neuroinflammation is acknowledged as a pivotal pathological event after cerebral ischemia. However, there is limited knowledge of the molecular and spatial characteristics of nonneuronal cells, as well as of the interactions between cell types in the ischemic brain. Here, we used spatial transcriptomics to study the ischemic hemisphere in mice after stroke and sequenced the transcriptomes of 19,777 spots, allowing us to both visualize the transcriptional landscape within the tissue and identify gene expression profiles linked to specific histologic entities. Cell types identified by single-cell RNA sequencing confirmed and enriched the spatial annotation of ischemia-associated gene expression in the peri-infarct area of the ischemic hemisphere. Analysis of ligand-receptor interactions in cell communication revealed galectin-9 to cell-surface glycoprotein CD44 (LGALS9-CD44) as a critical signaling pathway after ischemic injury and identified microglia and macrophages as the main source of galectins after stroke. Extracellular vesicle-mediated Lgals9 delivery improved the long-term functional recovery in photothrombotic stroke mice. Knockdown of Cd44 partially reversed these therapeutic effects, inhibiting oligodendrocyte differentiation and remyelination. In summary, our study provides a detailed molecular and cellular characterization of the peri-infact area in a murine stroke model and revealed Lgals9 as potential treatment target that warrants further investigation.
Surgical correction of astigmatism using corneal relaxing incisions or toric IOLs have been widely adopted to correct pre-existing astigmatism in cataract surgery patients. While the safety and efficacy of these procedures are well established, there are various challenges associated with these techniques that surgeons need to overcome to achieve good outcomes postoperatively; for instance, correction of astigmatism either with corneal relaxing incisions (CRIs) or toric IOLs during cataract surgery requires appropriate pre-operative planning based on corneal curvature measurements, biometry, nomogram/IOL selection, accurate marking for the placement of CRI/implantation of toric IOL on the intended axis, intraoperative alignment, cyclotorsion compensation, and postoperative IOL rotation, etc.

The Cassini Ambient and Catalys Femtosecond Laser incorporate this technology to help cataract surgeons accurately align toric IOLs on the intended axis of implantation or accurately place CRI on the intended meridian. This is expected to improve patients' visual functioning and reduce spectacle dependence postoperatively. The Cassini Ambient provides the preoperative anterior and posterior astigmatism with iris registration. The new Catalys Precision Laser System (Johnson \& Johnson Vision) with cOS 6.0 software facilitates direct importation of preoperative data from the Cassini via a wireless connection or USB drive, eliminates the need for manual axis marking as it compares the pre- and intra-operative iris anatomy data and compensates for tilt and rotation so that the laser marks are perfectly aligned to the steep meridian and the target axis. Linking preoperative diagnostic information to the laser minimizes data entry and transcription errors. It also eliminates several steps in the planning process for toric IOLs and CRI, thus improving the overall accuracy of the astigmatism correction procedure and reducing chances for error.
The invention provides an external use ointment, namely, an iodophor, castor oil and black bean distillate oil ointment used for treating skin wounds and anabrosis. The iodophor, castor oil and black bean distillate oil ointment is characterized by being prepared from iodophor, castor oil and black bean distillate oil, wherein black bean distillate oil can be replaced with pine distillate oil. According to the specific formula, the iodophor, castor oil and black bean distillate oil ointment is prepared from 0.5-8% of iodophor, 3-6% of black bean distillate oil (or pine distillate oil) and the balance castor oil. Iodophor has the broad-spectrum antimicrobial effect and has the functions of sterilization and inflammation diminishing. Due to the fact that the iodophor, castor oil and black bean distillate oil ointment does not contain alcohol or other stimulation components, the iodophor, castor oil and black bean distillate oil ointment is low in toxicity and free of stimulation to mucosa. Castor oil contains a large amount of ricinoleic acid, has many unique properties and has the effects of protecting wound surfaces, preserving moisture, removing sepsis and promoting healing of wounds and wound surfaces. Black bean distillate oil has the function of softening cutin, has the function of promoting cutin stripping, and can eliminate rotten and necrotic tissue. The iodophor, castor oil and black bean distillate oil ointment is used for treating skin wounds and anabrosis caused by various reasons.
Patients receive venetoclax PO QD on days 1-14 and azacitidine IV over 10-40 minutes on days 1-7 or days 1-5 of week 1 and days 1 and 2 of week 2. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Despite reading being an essential and almost universal skill in the developed world, reading proficiency varies substantially from person to person. To study why, the fMRI field is beginning to turn from single-word or nonword reading tasks to naturalistic stimuli like connected text and listening to stories. To study reading development in children just beginning to read, listening to stories is an appropriate paradigm because speech perception and phonological processing are important for, and are predictors of, reading proficiency. Our study examined the relationship between behavioral reading-related skills and the neural response to listening to stories in the fMRI environment. Functional MRI were gathered in a 3T TIM-Trio scanner. During the fMRI scan, children aged approximately 7 years listened to professionally narrated common short stories and answered comprehension questions following the narration. Analyses of the data used inter-subject correlation (ISC), and representational similarity analysis (RSA). Our primary finding is that ISC reveals areas of increased synchrony in both high- and low-performing emergent readers previously implicated in reading ability/disability. Of particular interest are that several previously identified brain regions (medial temporal gyrus (MTG), inferior frontal gyrus (IFG), inferior temporal gyrus (ITG)) were found to "synchronize" across higher reading ability participants, while lower reading ability participants had idiosyncratic activation patterns in these regions. Additionally, two regions (superior frontal gyrus (SFG) and another portion of ITG) were recruited by all participants, but their specific timecourse of activation depended on reading performance. These analyses support the idea that different brain regions involved in reading follow different developmental trajectories that correlate with reading proficiency on a spectrum rather than the usual dichotomy of poor readers versus strong readers.
Participants will have no intervention for the first 90 days, during which they will be asked not to start a new fasting program supplement. At day 91,start the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days.