anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants will complete two study visits in random order. For one visit, participants will consume popcorn (6 cups popped microwave popcorn), soda (32 oz Coke-a-cola), and candy (2.17 oz of Skittles) in the morning while fasting (i.e., the "fasting trial"). For the other visit, participants will report fasting and then first consume a high-fat meal (two Jimmy Dean's breakfast sandwiches; the "fed trial"). After consuming the high-fat meal during the fed trial, participants will be allowed to leave for three hours. During this three-hour period, the investigators will ask participants to only consume water and remain sedentary. Upon return, participants will consume the same movie theater style meal (popcorn, soda, candy).

Regardless of fasting or fed trials, procedures for this study will be largely similar between the two visits. Participants will arrive having fasted for \~10 hours, avoided exercise and alcohol for \> 24 hours, and avoided anti-inflammatory medications for \> 72 hours. First, the investigators will perform a baseline vascular ultrasound using the flow-mediated dilation (FMD) technique on all participants. Upon completion of FMD, the investigators will perform a blood draw in one of two ways (depending on the trial). For the fasting trial, the investigators will insert an indwelling intravenous catheter (IV) to minimize needle sticks. After a baseline blood sample is collected, participants will consume the movie theater-style meal and remain in the lab for four hours. During this time, the investigators will collect blood samples at 0.5-, 1-, 2-, 3-, and 4-hours post meal to measure potential changes in metabolic and inflammatory markers and indicators of endotoxemia. The investigators will also measure FMD at 2- and 4-hours post movie theater-style meal. During the fed trial, the investigators will first perform a single venipuncture to obtain a blood sample in order to have a true baseline sample for the fed trial. When participants return from this three-hour break, the procedures for the fed trial will be identical to the fasting trial (IV inserted, moving theater meal consumed, serial blood draws and FMD completed at the same timepoints over a four-hour period).
AIM: Patients requiring a beyond total mesorectal excision (bTME) procedure for locally advanced rectal cancer (LARC) and locally recurrent rectal cancer (LRRC) will probably benefit from enhanced recovery after surgery (ERAS) protocols. However, implementation of ERAS protocols in such groups of patients is considered challenging. The aims of this study were to evaluate ERAS-related outcomes of patients with LARC or LRRC undergoing bTME and to investigate the possibility of designing a tailored ERAS protocol.
METHOD: This study was divided into four phases. Phase one consisted of a literature study to compare functional recovery and postoperative outcomes in patients undergoing bTME. In phase two, outcomes on ERAS care elements in bTME were retrospectively evaluated. In phase three, differences in ERAS-related outcomes and compliance of the colorectal ERAS protocol in patients who had undergone bTME were studied. In phase four, multidisciplinary team meetings were held to develop an ERAS protocol for bTME patients.
RESULTS: Seven studies reported on ERAS-related outcomes in patients undergoing bTME. Median length of hospital stay was 9-19 days, median stay in the intensive care unit was 2-4 days and 30-day postoperative major complication rates were 22.6%-61.3%. Seventy-five bTME patients were included for retrospective analysis. In these patients, length of stay was 9.0 days and major postoperative complications were observed in 40.0%. The overall ERAS compliance was 44.4%. Compared with the colorectal ERAS protocol, the largest differences in management were observed in the use of epidural anaesthesia, the postoperative use of urethral catheters, oral intake and mobilization.
CONCLUSION: Patients undergoing bTME for LARC or LRRC are substantially different from patients treated with the colorectal ERAS protocol, regarding ERAS-related outcomes. A tailored, multimodal ERAS protocol with specific modifications was developed by an expert multidisciplinary team for patients undergoing bTME for LARC or LRRC.
PURPOSE:To measure the autoantibody for an antigen by culturing primarily the hepato-cells with a plate for tissue culture, immobilizing the monolayer of the hepato-cells and bringing the serum to be inspected and a labeled effecting agent into immnoreaction on said plate. CONSTITUTION:Hepato-cells are cultured in the well of a plate for tissue culture, for example, Williams E medium. The primary monolayer of the hepato-cells in the well is then fixed by a fixing agent, for example, parafomaldehyde. The serum to be inspected and a labeled effecting agent are added onto the plate and the immobilized hepato-cell antigen and serum are conjugated by immunoreaction and the labeled effecting agent is conjugated with such conjugate. The conjugated quantity is then measured. A radioactive material, enzyme active material, etc. are used for the labeled effecting agent. The quick measurement of the autoantibody for the hepato-cell membrane antigen with good accuracy is thus made possible by making the cultured and immobilized hepato-cells on the plate and bringing the same into immunoreaction, by which the liver disease is adequately diagnosed.
ELCYS® is approved for use in pediatric patients, from birth to 17 years of age, for use as an additive to amino acid solutions to meet the nutritional requirements of newborn infants, including preterm infants, requiring total parenteral nutrition (TPN) and pediatric patients with severe liver disease who may have impaired enzymatic processes and require TPN. The safety profile for ELCYS® use in pediatric patients includes risks of acid-base imbalance and hyperammonemia.

Acid-base imbalance, including metabolic acidosis, may occur with ELCYS® administration in preterm infants. Frequent clinical and laboratory assessments are necessary to monitor and manage fluid balance, electrolyte concentrations, and acid-base balance during parenteral nutrition therapy [see Warnings and Precautions (5.4)]. 

Hyperammonemia is of special significance in infants (birth to two years of age). This reaction appears to be related to a deficiency of the urea cycle amino acids of genetic or product origin. It is essential that blood ammonia be measured frequently in infants [see Warnings and Precautions (5.6)].

Because of immature renal function, preterm infants receiving prolonged parenteral nutrition treatment with ELCYS® may be at higher risk of aluminum toxicity [see Warnings and Precautions (5.7)].
In non-small-cell lung cancer, continuous immune-checkpoint inhibitors (ICIs) beyond progression are often used in clinical practice. On the other hand, there is almost no data on whether the concept of continuous ICIs beyond progression can be adopted in small-cell lung cancer (SCLC). We describe the effectiveness of continuous ICIs beyond progression in SCLC. Medical courses of SCLC patients treated with chemo-immunotherapy were retrospectively reviewed at our hospital. The study included 36 patients with a median age of 73 years (range 46-83 years) who introduced chemo-immunotherapy between September 2019 and December 2022. Atezolizumab and durvalumab in combination with platinum plus etoposide were administered in 24 and 12 patients, respectively. The overall response rate was 67% and the disease control rate was 86%. The median progression-free survival and time to treatment failure (TTF) were 5.1 and 10.3 months, respectively. The median cycle of ICIs was 5 (range 1-42). The median overall survival was 13.6 months. ICIs were administered beyond progression in 14 (39%) patients: five were treated again with chemo-immunotherapy and local ablative radiotherapy, four with local ablative radiotherapy and continuous ICIs, three with chemo-immunotherapy, and two with continuous ICIs alone. TTF exceeded 12 months in 12 (86%) of the 14 cases, six of which were still on ICIs. Adverse events ≥grade 3 were observed in 21 (58%) patients. A notable TTF suggested a benefit of continuous ICIs beyond progression. The concept could be suitably adopted and provide a favorable prognosis in selected cases of SCLC that were previously regarded as an aggressive malignancy.
The invention discloses the application of a kind of SATB1 in treatment cutaneous T cell lymphoma.The invention discloses and following arbitrary material is being prepared as the product of target spot the application prevented and/or treated in the medicine of cutaneous T cell lymphoma: (1) SEQ? ID? albumen shown in No.1; (2) SEQ? ID? DNA molecular shown in No.2; (3) SEQ? ID? in No.2 from 5 ' end the DNA molecular shown in the 1736th to the 4024th nucleotide.SATB1 protein-specific be expressed in the tumorous T cell of CD30+ in cutaneous T cell lymphoma skin lesion, and find the expression of SATB1 albumen increase can by promote cell cycle progress and cutaneous T cell lymphoma morbidity and progress in play important effect, SATB1 as target spot treatment cutaneous T cell lymphoma in be with a wide range of applications.
Midline catheters have recently gained popularity in clinical use, with a common reason being the reduction of central venous catheter use and central line-associated bloodstream infections. At the same time, the number of nononcology vesicant medications has increased, and midline catheters are frequently being used for infusions of vesicant medications. The Infusion Nurses Society (INS) Vesicant Task Force identified midline catheter use as a possible risk factor for extravasation and concluded that a thorough literature review was necessary. This review highlights the variations in catheter terminology and tip locations, the frequency of infiltration and extravasation in published studies, and case reports of infiltration and extravasation from midline catheters. It also examines the many clinical issues requiring evidence-based decision-making for the most appropriate type of vascular access devices. After more than 30 years of clinical practice with midline catheters and what appears to be a significant number of studies, evidence is still insufficient to answer questions about infusion of vesicant and irritant medications through midline catheters. Given the absence of consensus on tip location, inadequate evidence of clinical outcomes, and importance of patient safety, the continuous infusion of vesicants, all parenteral nutrition formulas, and infusates with extremes in pH and osmolarity should be avoided through midline catheters.
The puerperal / postpartum women who evolved with sepsis, needing support by invasive mechanical ventilation, were evaluated and monitored with Electrical Impedance Tomography for ventilatory therapy. In order to obtain the images and quantification of the regional ventilatory distribution, two strips with 16 electrodes were connected around the thorax to capture an imperceptible and harmless electric current to the patient, generating, according to the pulmonary dynamics, an impedance power of variation. A flow sensor was positioned between the endotracheal tube and the "Y" of the ventilator circuit and was responsible for capturing information about ventilatory mechanics. Data were sent simultaneously to a system (computer) with specific softwear in order to measure and quantify the regional distribution of pulmonary ventilation and perfusion, as well as their correlation.
Anatomical changes that adversely affect airway accessibility due to increased adipose tissue in obese patients make it difficult to establish an advanced airway by orotracheal intubation. Difficulty with airway management for anesthesia has potentially serious implications, as failure to secure a patent airway can result in hypoxic brain injury or death in a matter of minutes. There have been no effective methods to predict difficult airways accurately. Ultrasonography is a non-invasive, safe, and painless modality for evaluating soft tissues. In recent years, studies have been carried out on the parameters that can be used in determining the difficult airway with ultrasound. These include the distance from the skin to the epiglottis, the tongue thickness, the tongue volume, the mandibular condylar mobility, and the visibility of the hyoid. Few studies have whether midsagittal tongue cross section area and tongue width can also be used to predict difficult airways similarly to tongue volume. Therefore, this study was designed to evaluate the predictive value of accurately measured tongue thickness and cross-sectional tongue area using ultrasonography for predicting difficult tracheal intubation and difficult laryngoscopy.
<P>PROBLEM TO BE SOLVED: To provide a POS register that, when commodities bought by a customer include a commodity that could cause a problem if used in combination, can report it when registering the commodity, without relying on a clerk's knowledge of commodities.  <P>SOLUTION: A determination is made as to whether a commodity code inputted is stored in a combination file (step S1-3). A determination is made as to whether a registered commodity table stores the commodity code stored in the combination file (step S4-5). Caution data indicating the possibility that a commodity could cause a problem if used in combination is displayed (step S6) and a determination is made as to whether the commodity is to be registered (step S7). The caution data is stored, commodity registration proceeds, an account is closed, and settlement is made (step S8-12). The caution data stored is printed on a receipt about the settlement (step S13-15).  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The invention relates to an anion far-infrared fabric chest-tightening strap (bag) with nano selenium and traditional Chinese medicine for preventing and curing hepatitis. Chronic virus hepatitis, hepatitis B, hepatitis A and non-B hepatitis C circulates in China for many years, and are the early symptoms of the hepatocirrhosis and the liver canceration. However, an effective therapeutic method and specific drugs are not found currently. The nano selenium can improve the symptoms of asthenia and the like of a patient, protect the liver, prevent the hepatitis from developing into the hepatocirrhosis, the hepatic necrosis or the liver cancer, urge the liver cells to regenerate, prevent the damage to the liver cells by free radicals, relieve the hurt to the liver by the flavacin and hazardous materials, resist the viruses and resist the infection. The nano silver can kill all the bacteria and viruses. The nano micro powder prepared from mineral materials and traditional Chinese medicine by the nano technology is converted into heat energy by the temperature of a human body and the far infrared ray and is transmitted in vivo, thereby accelerating the blood flow and circulation and accelerating the medicinal effect; the anion promotes the acid-base balance of the human body, increases the permeability of the cell membrane, and increases the oxygen content of the blood; and the medical stone fibers can purify the blood, eliminate the toxin and resist the pollution. Therefore, the fabric chest-tightening strap (bag) for preventing and curing hepatitis has the specific effects of preventing and curing the hepatocirrhosis and the canceration of patients with hepatitis B.
The invention discloses an oral enteric-coated preparation adopting alkalescence PH regulator as medicine active component and an industrial preparation method of the preparation. The alkalescence PH regulator is selected from one of baking soda, KHCO3, sodium carbonate, citric acid, sodium citrate, potassium citrate, potassium sodium hydrogen citrate or a mixture of the substances. The medicine compound of the invention is not released in stomach but in bowel, so as to avoid defects of the existing common oral preparation that is release in stomach and is counteracted with stomach acid to cause loss of the medicine component, hiccup and gastrectasia, etc. Then the medicine effect can be thoroughly performed, and bad reaction can be greatly alleviated and the toleration of the sufferers can be greatly enhanced. In the clinical application, the invention can be used for regulating acid-alkali balance of body, correcting acid body nature, basifying urine liquid, treating metabolic acidosis and gout, etc. diseases.
The DFS+ experimental group is designed to increase utilization of free sunscreen dispensers, applying and reapplying sunscreen, and motivating use of other forms of sun protection by teens in 8 Boston parks and 2 Maine beaches. IMPACT Melanoma will install and maintain free sunscreen dispensers at the study sites. Flyers will be posted at locations at the park/beach to inform people of the availability of free sunscreen and the location of the dispenser. 'Teen enhanced' signage will be present on the dispenser in the intervention parks/beaches. Teen ambassadors will share 3-5 posts to their social media platform over the course of 1 week encouraging sun protection practices and use of the free sunscreen dispenser (when the intervention is occurring at the study site).
Participants were asked to go about their normal activities during the first 2 baseline days of participation. Participants were asked to spend an additional 30 minutes outdoors per day for the next 5 days of participation.
We will enroll 520 current smokers in the study. All subjects will participate in an initial smoking cessation intervention involving brief counseling and nicotine replacement therapy. Participants who are able to achieve at least 3 consecutive days of abstinence will be randomized to one of two relapse prevention interventions. The participants in Study Arm 1 will receive a hypnosis intervention designed to facilitate relapse prevention. Participants in Study Arm 2 will participate in empirically-supported behavior relapse prevention counseling, utilizing the National Cancer Institute's Forever Free materials. Both interventions will be conducted in two 60-minute individual sessions scheduled one week apart in addition to counseling phone calls on their quit date and after relapse prevention treatment.

Outcomes for the two study arms will be compared by assessing biochemically-validated point-prevalence smoking status at 9 weeks(end of treatment), 26 weeks and 52 weeks. Hypnosis for relapse prevention is designed to sustain the ex-smokers commitment to remain abstinent, to provide a review of behavioral skills to resist the temptations to smoke, and to encourage attempts to quit again if relapse occurs.
Patients will participate in a total of 1.5hour/day for 8 weeks with 1:1 (therapist to patient) ratio. During each session, all patients will perform 5 to 10 minutes warm-up tasks, then practiced the selected tasks for the rest of the time.
NEW MATERIAL:A spiroisoxazoline of formula I (R<1>, R<2> are H, lower alkoxy; R<3>, R<4> are lower alkyl, aralkyl, aryl, which may be substituted and R<3> and R<4> may form a hyterocyclic ring together with an adjacent nitrogen atom). EXAMPLE:8-Oxo-1-oxa-2-azaspiro[4,5]-deca-2,6,9-triene-3-carboxylic acid N,N- dimethylamide. USE:It is useful as a drug, because of its carcinostatic activity. It features in low toxicity and high stability. PREPARATION:A carboxylic acid or its reactive derivative of formula II is allowed to react with an amine of formula III or its reactive derivative in a solvent such as benzene at room or lower temperature to give the compound of formula I . In an alternate way, an amidoxim derivative of formula IV is subjected to ring closure under acidic conditions to give the compound of formula I .
Despite research establishing the relationship between sleep disturbances and alcohol use, there is no clear understanding or model for what occurs once individuals who seek inpatient alcoholism treatment are discharged from rehabilitation facilities and attempt to integrate back into their homes and communities. The purpose of this investigation will be to characterize sleep patterns, perceptions, and beliefs throughout the process of alcohol rehabilitation. The misuse of alcohol is a global public health concern that compromises both individual and societal wellbeing, resulting in an estimated 2.5 million deaths annually. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) distinguishes alcoholism by craving, loss of control, physical dependence, and tolerance (NIAAA, Alcohol Use Disorders). The relationship between alcohol use and sleep disturbances is complex and bidirectional, but sleep disturbances are common among alcoholics during phases of drinking, withdrawal, and abstinence. Outcome expectancies, behavioral capability, and self-efficacy beliefs are central constructs in the Social Cognitive Theory and will be measured directly in this study using both quantitative and qualitative methods. A mixed methods approach will be used to study the following aims: a) to assess individuals' perceptions of and experiences with sleep during alcohol rehabilitation, b) to describe sleep patterns, perceptions, and beliefs among alcohol-dependent individuals throughout the transition from a clinical research facility providing rehabilitation treatment back to the community, c) to assess whether sleep-related beliefs and/or behavior of individuals are predictive of sleep quality or relapse to drinking, and d) to assess whether sleep quality predicts relapse. Adult research participants admitted to the inpatient behavioral health unit and enrolled on to the NIAAA intramural study NCT 0010693: Assessment and Treatment of People with Alcohol Drinking Problems will be recruited for participation in this study (n=215). Sleep quality and duration will be quantitatively assessed approximately one week prior to discharge from the inpatient facility and again 4-6 weeks post-discharge. A sub-set of participants will be asked to wear actiwatches (accelerometers) to provide objective data on sleep throughout the transition from inpatient to outpatient. In addition to quantitative measures, qualitative semi-structured interviews will be conducted with a subset of 25 participants (to reach 25 completed cases) within a week of the scheduled discharge date and again four to six weeks post-discharge to assess perceptions of sleep during recovery. The proposed study will fill a gap in the literature by characterizing sleep throughout the rehabilitation process and ongoing maintenance of abstinence.
BACKGROUND: Although the impact of surgery- and patient-dependent factors on surgical-site infections (SSIs) have been studied extensively, their influence on the microbial composition of SSI remains unexplored. The aim of this study was to identify patient-dependent predictors of the microbial composition of SSIs across different types of surgery.
METHODS: This retrospective cohort study included 538 893 patients from the Swiss national infection surveillance programme. Multilabel classification methods, adaptive boosting and Gaussian Naive Bayes were employed to identify predictors of the microbial composition of SSIs using 20 features, including sex, age, BMI, duration of surgery, type of surgery, and surgical antimicrobial prophylaxis.
RESULTS: Overall, SSIs were recorded in 18 642 patients (3.8%) and, of these, 10 632 had microbiological wound swabs available. The most common pathogens identified in SSIs were Enterobacterales (57%), Staphylococcus spp. (31%), and Enterococcus spp. (28%). Age (mean feature importance 0.260, 95% c.i. 0.209 to 0.309), BMI (0.224, 0.177 to 0.271), and duration of surgery (0.221, 0.180 to 0.269) were strong and independent predictors of the microbial composition of SSIs. Increasing age and duration of surgical procedure as well as decreasing BMI were associated with a shift from Staphylococcus spp. to Enterobacterales and Enterococcus spp. An online application of the machine learning model is available for validation in other healthcare systems.
CONCLUSION: Age, BMI, and duration of surgery were key predictors of the microbial composition of SSI, irrespective of the type of surgery, demonstrating the relevance of patient-dependent factors to the pathogenesis of SSIs.