anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This utility model relates to a kind of G. Elata B1f. G1auca S Chow processing technique boiling sterilization dries three-in-one unit, it is characterized in that, structure comprises device body, steaming and decocting chamber is processed with bottom device body, middle and lower part, steaming and decocting chamber is provided with the first branched pipe, middle and upper part, steaming and decocting chamber is provided with the second branched pipe, steaming and decocting is provided with Three branched pipe bottom chamber, device body inside is provided with for placing the latticed hollow out basket of pending G. Elata B1f. G1auca S Chow, device body top is provided with the upper cover body matched with device body, upper cover body bottom centre position is provided with ultraviolet germicidal, device body medial wall is provided with carbon fiber infrared heating tube.This utility model improves G. Elata B1f. G1auca S Chow steaming and decocting, sterilizing and drying efficiency, simplifies G. Elata B1f. G1auca S Chow treatment process, avoids the mechanical damage to G. Elata B1f. G1auca S Chow product and pollution, ensures product quality, improving production efficiency, saves labour cost.
Integrated Behavioral Therapy consists of 5 weekly one-hour sessions (face-to-face either through video or in-person) + 2 telephone check-in with an interventionist. This program integrates cognitive-behavioral treatment for nocturia and insomnia. Brief telephone check-ins will be comprised of review of topics discussed during the sessions.
Nosocomial infections (NIs) are a major public health problem worldwide . Nosocomial infections are those acquired in or associated with hospitals. They are also known as hospital-acquired or healthcare-associated infections. The usual deﬁnition of a hospital-acquired infection is one that was not present or incubating when the patient was admitted to a hospital or healthcare facility; where there is doubt, a cut-off period of 48 hours after admission is used.The terms hospital-acquired and healthcare-associated are often used interchangeably, but 'healthcare-associated' also has the wider meaning of any infection acquired as a result of healthcare in any setting.

Nosocomial infections are common, and may be serious or fatal. Some are unavoidable but doctors' duty of care to their patients extends to fundamental matters such as basic hygiene, which may prevent patients becoming infected, and avoidance of unnecessary antibiotics, to discourage development of resistance Health care-associated infections (HC-AIs) are a major cause of morbidity and mortality in neonatal intensive care units (NICUs) and lead to increases in hospital length of stay and treatment cost. Higher nosocomial infection incidence in NICUs was related to longer duration of hospital stay, and invasive interventions and medical treatments. HC-AIs, especially device-associated health care-associated infections (DA-HAIs), were also common in newborns because of their insufﬁcient immune system and mechanical barriers, as well as lack of protective ﬂora
The invention relates to a preparation method of a traditional Chinese medicinal composition oral liquid for treating cholecystitis and cholelithiasis. Cholecystitis comprises acute cholecystitis and chronic cholecystitis, and clinically comprises hypochondriac pains, jaundice and other symptoms in Chinese medical science. Cholecystitis is caused by liver qi stasis, dysfunction of spleen in transportation, and stagnation of damp-heat. Cholelithiasis related diseases are characterized by hypochondriac pains, stomachache and jaundice in the traditional Chinese medicine science. The cholelithiasis is caused by liver stasis and qi stagnation and stagnation of damp-heat, and impurities in bladder form stones after liver and bladder suffer from bile leakage for a long time. Special bioactive substances with heat clearing and dampness removing, blood stasis dispersing and pain easing, stone eliminating and stasis dispelling, and urination promoting and stone expelling effects are prepared by using biological technologies to treat the cholecystitis and cholelithiasis.
1,170,152. Crackling cosmetics. REXALL DRUG & CHEMICAL CO. 9 Jan., 1967 [10 Jan., 1966], No. 1202/67. Heading A5B. [Also in Division C4] A pressurised composition which upon release of pressure forms a foam which exhibits a crackling sound when subjected to shear comprises from 75% to 95% by weight of a chlorofluorocarbon propellant system having a vapour pressure of from 10 to 30 p.s.i.g. at 70‹F, the propellant being emulsified as the dispersed phase in an aqueous continuous phase in the presence of a water-dispersible emulsifier in an amount sufficient to yield a stable emulsion. Various propellants and emulsifiers are specified and examples are given of pre-shave and after-shave lotions, colognes, a cleansing cream and an astringent composition.
Patients undergo whole-brain radiation therapy QD 5 days a week for 15 fractions. Patients also receive berzosertib IV over 60-90 minutes twice a week, 18-30 hours after first radiation therapy. Treatment continues for 3 weeks in the absence of disease progression or unacceptable toxicity.
Lung transplantation stands as a vital treatment for severe lung diseases, primarily sourcing organs from donors with brain death (BD). This research delved into the potential anti-inflammatory effects of thalidomide in rats with BD-induced lung complications. In this study twenty-four Wistar rats were divided into three groups: the control (CTR), brain death (BD) and brain death + thalidomide (TLD) groups. Post specific procedures, a 360 min monitoring period ensued. Comprehensive analyses of blood and heart-lung samples were conducted. Elevated IL-6 levels characterized both BD and TLD groups relative to the CTR (p = 0.0067 and p = 0.0137). Furthermore, TNF-α levels were notably higher in the BD group than both CTR and TLD (p = 0.0152 and p = 0.0495). Additionally, IL-1β concentrations were significantly pronounced in both BD and TLD compared to CTR, with the BD group surpassing TLD (p = 0.0256). Immunohistochemical assessments revealed augmented NF-ĸB expression in the BD group in comparison to both CTR and TLD (p = 0.0006 and p = 0.0005). With this study we can conclude that BD induced acute pulmonary inflammation, whereas thalidomide manifested a notable capability in diminishing key inflammatory markers, indicating its prospective therapeutic significance in lung transplantation scenarios.
Eligibility for participation of this study will be determined from demographic information, medical history, physical examination, electrocardiogram (ECG) and clinical laboratory tests within 4 weeks before study drug administration. Subjects suitable for this study will be admitted to the Clinical Trials Center, Seoul National University Hospital on the day before dosing, and they were overnight-fasted from 10 p.m. of Day -1. Urine collection is scheduled drug 12 hour before and 24 hour after midazolam administration. Subjects will be dosed study drug via intravenous around at 9 a.m. of Day 1. Subjects performed scheduled procedures.

In period 2, Subjects will be admitted on Day 3-5. Subjects performed scheduled period 2 (Itraconazole co-administration phase, 2 times administration of itraconazole 200 mg), and period 3 (rifampicin 150 mg co-administration phase) procedure. Study participation was terminated on post-study visit (Day 23\~35).
The patient-centered medical home (PCMH) is an exciting strategy that has the potential to revolutionize hematopoietic stem cell transplantation (HCT). Traditionally, home care has been used for palliative care in end-stage cancer patients and in geriatrics. More recently the PCMH has gained increasing adoption for both primary care and care of medically complex patients. The core of the PCMH lies in the interaction between the healthcare team, the patient's family and support, and above all, the patient. These interactions can be enhanced through health information technologies such as the electronic health record (EHR) and videoconferencing via iPads. In addition, collection of patient reported outcomes (PRO) will allow feedback and adjustments.

This integration is especially important when considering the multiple complicated needs of the HCT patient: navigating a Byzantine healthcare system that often requires input and coordination from multiple specialists including transplanters, hematologists, infectious disease physicians, gastroenterologists, psychiatrists, nutritionists, pharmacists, social workers, financial coordinators, etc.; managing medication regimens to prevent infections, GVHD, and other complications (not to mention avoiding drug and food interactions); adjusting to multiple side effects including fatigue, weakness, anorexia, nausea, vomiting, diarrhea, rashes, pain, anxiety, stress, organ failure, etc.; the sheer amount of time required for healthcare visits, lab draws, waiting for results, infusions, transfusions, etc.; physical and psychosocial struggles of living with a life-threatening disease; and the burdens of a treatment that often seems as debilitating as the disease. The PCMH provides patient-centered, comprehensive, accessible, and coordinated care and a systems-based approach to quality and safety: these attributes are essential to the successful care of the complicated HCT patient. this approach has the potential to lower overall costs while preserving or increasing the quality of care.
The invention relates to a traditional Chinese medicine composition for treating the uremia, and belongs to the technical field of traditional Chinese medicine preparing. The composition comprises orally-taken medicine and external application medicine. The orally-taken medicine comprises, by weight, 3 parts to 8 parts of first-class ginseng, 3 parts to 8 parts of semen plantaginis, 3 parts to 8 parts of capillary artemisia, 3 parts to 8 parts of herba cistanche, 3 parts to 8 parts of mulberries, 3 parts to 8 parts of fructus psoraleae, 5 parts to 10 parts of lalang grass rhizomes, 5 parts to 10 parts of semen cuscutae, 5 parts to 15 parts of lophatherum gracile, 5 parts to 10 parts of bighead atractylodes rhizomes, 10 parts to 20 parts of raw radix astragalis and 10 parts to 30 parts of fried sticky rice. The external application medicine comprises, by weight, 50 parts to 80 parts of raw garlic and 20 parts to 50 parts of mirabilite. The preparing method of the orally-taken medicine includes the steps that refluxing is carried out on the traditional Chinese medicinal materials with the weight parts through ethyl alcohol with the volume ten times that of the traditional Chinese medicinal materials, and extracting, separating and drying are carried out for standby application. The preparing method of the external application medicine includes the step that the traditional Chinese medicinal materials with the weight parts are mixed in proportion to be mashed to be pasty for standby application. According to the traditional Chinese medicine composition, oral taking and external application are combined; after continuous taking is carried out, the functions of clearing away heat, cooling blood, eliminating toxins, warming and activating meridians and promoting blood circulation to remove blood stasis are achieved, fibrosis of kidney tissues is relieved, the kidney functions are gradually restored finally, and the curing effect is achieved.
In breast surgery, regional anesthesia associated with general anesthesia during surgery has shown great results for the post-operative pain management, prevention of tumor recurrence and development of neuropathic pain. It has been shown that regional anesthesia attenuates the inflammatory response and systemic changes postoperatively during breast surgeries. Thus, it is important to include an additional analgesic intervention in breast surgery in order to decrease the local inflammatory response and the postoperative pain. Thus, the serratus anterior muscle plane (SAM) block associated with pectoral nerve block type I (PEC I) may be a safe and effective alternative for the intraoperative of breast surgery, since there is evidence of pain reduction. However, correlation between regional anesthesia, postoperative pain and inflammatory response in breast surgery has not been demonstrated. The aim of this study is to compare the standard intravenous analgesia versus systemic analgesia associated with the SAM block and PEC I during breath cancer surgery. The following parameters will be evaluated: consumption of opioid intra and post-operative; post-operative pain and release of plasma inflammatory cytokines. It is a clinical prospective, randomized and controlled study. Also, it will be evaluated the development of chronic neuropathic pain 12 months after mastectomy, the use of analgesic medication, quality of life, depressive symptoms, and the levels of interleukin (IL)-1 beta, IL-6, and IL-10 as predictors of pain and depression. 50 individuals will be randomly divided into two groups. A group of patients receive general anesthesia during surgery and intravenous analgesia after the surgery and another group will receive general anesthesia associated with SAM and PEC I block during intraoperative and postoperative systemic analgesia. The postoperative pain will be assessed using the Visual Analogue Scale pain in the recovery room and 24 hours after surgery. Blood sample will be collected for determination of serum cytokines before surgery and 24 hours after the surgery.
The intervention is planned with a goal of restricting the calorie intake to 40 Kcal/Kg BW/day, around 10-15 % of total calories from protein, 30-35% from fats and 55-60% from carbohydrates. Major portion of the carbohydrates is Western fast food comprising of pizza and burger, French fries, sweets, muffins, cakes, chocolates, sugar sweetened beverages.
Cannabidiol may be used by patients because it may have beneficial pharmacological effects (including anxiolytic, analgesic, anti-inflammatories or antioxidant effects). Older adults aged 65 years and over, are more frequently at risk of multimorbidity and loss of autonomy, and may present with several symptoms like pain, anxiety, sleep disturbances, that may potentially respond to CBD. The molecule is often marketed as devoid of adverse effects. Nevertheless, with ageing, reduction in liver and kidney function, may have an impact on the metabolism and elimination of CBD and increase the risk of side-effect. As well, the risk of interaction with drugs frequently prescribed in older adults such as CYP3A4 inhibitors (verapamil, ketoconazole ...), CYP3A4 inducers (phenytoin, carbamazepine, ...) or CY92C19 inhibitors or inducers (fluoxetine ...), may increase the risk of side effects. Our hypothesis is that the use of CBD has increased last years in older adults, but that they are insufficiently informed about this molecule. There is a need to assess the prevalence of CBD use in older adults in France, to assess the knowledges of CBD users about this substance, and to better characterize CBD users.
Intervention was applied to classroom teachers by the RRIDA Project team. Training lasted six weeks, 12 hours devoted to physical activity and 18 hours to nutritional content. Modules of educational activities were taught in order to be replicated at PE classes to 1st and 2nd grades' children of three exposed schools. Physical activity module was based on a theoretical approach of physical activity benefits and risks for health, children's physical fitness and activity patterns, physical education and change behavior models. In each meeting the PE professionals, performed PE classes with the classroom teachers as students, focusing in strategies to keep them in movement for the most of PE class time to stimulate students' joint participation instead of individual participation or games.
PURPOSE: To freely control the release rate of a medicine from an adsorption carrier. CONSTITUTION: This powdery agent is prepared by adsorbing a hydrophobic medicine such as vitamin K1 on an adsorption carrier, chemically modified with hydrophobic groups such as alkyl groups and having the surface undergoing the hydrophobic treatment and further a porous structure such as silica gel. Since the hydrophobic medicine is efficiently powdered and the consistency and cohesiveness are deteriorated, the handleability can remarkably be improved in a process for formulating the medicine into a pharmaceutical preparation. The air oxidation, photodecomposition, etc., can effectively be suppressed. At least one factor of the pore diameter, grain diameter and degree of the hydrophobic surface treatment of the adsorption carrier, as desired, can suitably be set to thereby regulate the diffusion rate of the medicine in pores of the adsorption carrier, e.g. in an alimentary canal.
INTRODUCTION AND HYPOTHESIS: Pelvic floor disorders (PFDs), significantly impacting women's quality of life, are often underdiscussed owing to misconceptions and limited understanding of treatment options. This study is aimed at validating an Arabic version of the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) to assess knowledge of pelvic organ prolapse (POP) and urinary incontinence (UI) among Arabic-speaking women, addressing knowledge gaps in these areas.
METHODS: The study obtained ethical approval and followed a two-stage process, including a pilot study for preliminary validation and a larger study involving 300 participants. The PIKQ, a self-administered tool with two scales focusing on UI and POP, was translated into Arabic with cultural and linguistic adaptations. The study evaluated the reliability and validity of the Arabic PIKQ, employing Cronbach's alpha, intraclass correlation coefficient (ICC), and Spearman's rho for reliability assessments, as well as factor analysis for construct validity.
RESULTS: The Arabic PIKQ demonstrated high internal consistency (Cronbach's alpha > 0.8) and test-retest reliability (ICC > 0.79) for both the UI and the POP scales. The questionnaire also showed significant construct validity. Among the 300 participants, knowledge gaps were evident, influenced by educational and professional backgrounds. Notably, 22% reported UI and 14.7% reported pelvic organ prolapse, with less than half seeking treatment.
CONCLUSIONS: The Arabic PIKQ has been validated as a reliable tool for improving knowledge and addressing misconceptions regarding PFDs among Arabic-speaking women. The study underscores the importance of culturally sensitive educational tools in enhancing awareness and facilitating access to medical care for pelvic floor disorders.
The invention provides a baking powder. The baking powder contains silicon processed talcum powder, nylon powder, magnesium aluminosilicate, a xanthan gum, mica powder, silica, polydimethylsiloxane, triglyceride, a coloring agent, ethylhexyl glyceride, sodium benzoate and monoglyceride. The invention also provides a preparation method of the baking powder. The baking powder is suitable for making makeup products comprising eye shadow/pressed powder/rouge/bronzer powder and the like. The baking powder made through adopting the method solves technical problems comprising insufficient coloring brightness, low pearlescent application amount, insufficient resplendent effect, bad color saturation, and bad luster brightness of the baking powder made through a routine method. In the invention, large amounts of pearlescent powder and mica can be added, so the color is bright, the pearlescent effect is resplendent and stereo, and the baking powder is close to skins; and the baking powder made through the method provided by the invention is better than the baking powder made through the routine method in appearance structure, color saturation, luster brightness, powder condensation, and break and shake resistances.
SAR442168 administered alone and together with gemfibrozil. 1 day washout for each administration of SAR442168.
BACKGROUND: Children with cancer receiving chemotherapy commonly report a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, depression, and cognitive dysfunction. The role of the gut microbiome and its functional metabolites in PNS is rarely studied among children with cancer. This study investigated the associations between the gut microbiome-metabolome pathways and PNS in children with cancer across chemotherapy as compared to healthy children.
METHODS: A case-control study was conducted. Cancer cases were recruited from Children's Healthcare of Atlanta and healthy controls were recruited via flyers. Participants reported PNS using the Pediatric Patient-Reported Outcomes Measurement Information System. Data for cases were collected pre-cycle two chemotherapy (T0) and post-chemotherapy (T1), whereas data for healthy controls were collected once. Gut microbiome and its metabolites were measured using fecal specimens. Gut microbiome profiling was performed using 16S rRNA V4 sequencing, and metabolome was performed using an untargeted liquid chromatography-mass spectrometry approach. A multi-omics network integration program analyzed microbiome-metabolome pathways of PNS.
RESULTS: Cases (n = 21) and controls (n = 14) had mean ages of 13.2 and 13.1 years. For cases at T0, PNS were significantly associated with microbial genera (e.g., Ruminococcus, Megasphaera, and Prevotella), which were linked with carnitine shuttle (p = 0.0003), fatty acid metabolism (p = 0.001) and activation (p = 0.001), and tryptophan metabolism (p = 0.008). Megasphaera, clustered with aspartate and asparagine metabolism (p = 0.034), carnitine shuttle (p = 0.002), and tryptophan (p = 0.019), was associated with PNS for cases at T1. Gut bacteria with potential probiotic functions, along with fatty acid metabolism, tryptophan, and carnitine shuttle, were more clustered in cancer cases than the control network and this linkage with PNS needs further studies.
CONCLUSIONS: Using multi-omics approaches, this study indicated specific microbiome-metabolome pathways linked with PNS in children with cancer across chemotherapy. Due to limitations such as antibiotic use in cancer cases, these findings need to be further confirmed in a larger cohort.
We investigated subarachnoid haemorrhage (SAH) macrophage subpopulations and identified relevant key genes for improving diagnostic and therapeutic strategies. SAH rat models were established, and brain tissue samples underwent single-cell transcriptome sequencing and bulk RNA-seq. Using single-cell data, distinct macrophage subpopulations, including a unique SAH subset, were identified. The hdWGCNA method revealed 160 key macrophage-related genes. Univariate analysis and lasso regression selected 10 genes for constructing a diagnostic model. Machine learning algorithms facilitated model development. Cellular infiltration was assessed using the MCPcounter algorithm, and a heatmap integrated cell abundance and gene expression. A 3 × 3 convolutional neural network created an additional diagnostic model, while molecular docking identified potential drugs. The diagnostic model based on the 10 selected genes achieved excellent performance, with an AUC of 1 in both training and validation datasets. The heatmap, combining cell abundance and gene expression, provided insights into SAH cellular composition. The convolutional neural network model exhibited a sensitivity and specificity of 1 in both datasets. Additionally, CD14, GPNMB, SPP1 and PRDX5 were specifically expressed in SAH-associated macrophages, highlighting its potential as a therapeutic target. Network pharmacology analysis identified some targeting drugs for SAH treatment. Our study characterised SAH macrophage subpopulations and identified key associated genes. We developed a robust diagnostic model and recognised CD14, GPNMB, SPP1 and PRDX5 as potential therapeutic targets. Further experiments and clinical investigations are needed to validate these findings and explore the clinical implications of targets in SAH treatment.