anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A container storing pills or other discrete objects and which provides restricted access to the pills. The container has a rotatable pill drum allowing selective access to pills when the drum is rotated to various dispensing positions. A rotatable combination disk or other component is provided that has a plurality of channels formed therein and which can be rotationally locked to the drum. Movable pegs engage the channels. Each dispensing position has an associated peg position combination. Rotation of the pill drum from one dispensing position to the next is blocked unless the pegs are moved into the appropriate peg position combination. The pill drum can be rotated from one dispensing position to the next using a handle or via an automatic spring loaded mechanism.
ALS subjects in this arm, who are offered NIV for Forced Vital Capacity (FVC) \<50% as per AAN Practice Parameters, will have their initial level of NIV determined polysomnographically. They will be followed with sleep studies at 1 month, 3 months and 6 months to reassess NIV efficacy and NIV will be adjusted as necessary to optimize parameters of oxygenation and ventilation.
In the Simple Text+Video sub-arm, together with the appointment link, participants will also receive a link to a 2-minute video in the text message. The video contains information about the prevalence of COVID-19 and the effectiveness and safety of the COVID-19 vaccine.
The invention provides a nucleic acid encoding the 37-kDa protein from  Streptococcus pneumoniae . Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are antibodies which selectively binds the polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are vaccines comprising immunogenic polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Further provided is a method of detecting the presence of  Streptococcus pneumoniae  in a sample comprising the steps of contacting a sample suspected of containing  Streptococcus pneumoniae  with nucleic acid primers capable of hybridizing to a nucleic acid comprising a portion of the nucleic acid encoding the 37-kDa protein, amplifying the nucleic acid and detecting the presence of an amplification product, the presence of the amplification product indicating the presence of  Streptococcus pneumoniae  in the sample. Further provided are methods of detecting the presence of  Streptococcus pneumoniae  in a sample using antibodies or antigens, methods of preventing and treating  Streptococcus pneumoniae  infection in a subject.
PURPOSE:To obtain a skin detergent, having foaming functions in addition to makeup removing functions and capable of providing a refreshing feeling of washing the bare skin by combining a polyoxyethylene diester with a specific anionic surfactant. CONSTITUTION:This skin detergent contains a polyoxyethylene diester expressed by the formula [R is a saturated or an unsaturated higher aliphatic hydrocarbon group; (n) is 6-16] and an anionic surfactant except a fatty acid soap. A polyoxyethylene diisocyanate and a polyoxyethylene dioleate are especially preferred as the polyoxyethylene diester expressed by the formula. For example, an alpha-acylsulfonate, an alkylsulfonate and an alkylallyl- and an alkylnaphthalenesulfonates are cited as the anionic surfactant. The blending ratio of the polyoxyethylene diester to the anionic surfactant is preferably within the range of (1:1) to (1:8) expressed in terms of weight ratio. The total amount of both blended therein is within the range of 1-80wt.% based on the total amount of the detergent.
<P>PROBLEM TO BE SOLVED: To provide a means for promoting the unusual immunosuppression of a xenograft.  <P>SOLUTION: There is provided the means and method for inhibiting T-cell mediated rejection of a xenografted organ by blocking the delivery (B7/CD28 interaction) of co-stimulatory signal 2 in order to prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, the co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 derived from the xenogeneic donor organism. This preferentially binds B7 on a xenograft and blocks the interaction between B7 on a xenogeneic donor cells and CD 28 on a recipient T-cells. In a second aspect, the co-stimulation is antagonized by developing such a ligand of CTLA-4 on a xenogeneic donor cells as is to bind CTLA-4 on a recipient's activated T-cells to thereby antagonize the signal 2.  <P>COPYRIGHT: (C)2011,JPO&INPIT
BACKGROUND: Treadmill gait training has been shown to improve gait performance in People with Parkinson's Disease (PwPD), and in combination with Virtual Reality, it can be an effective tool for gait rehabilitation. The addition of gamification elements can create a more stimulating and adherent intervention. However, implementation of new technologies in healthcare can be challenging. This study aimed to develop and evaluate the feasibility of a treadmill rehabilitation program in a Gamified Virtual Reality Environment (GVRE) for PwPD.
METHODS: The GVRE was developed following a user-centered design approach, involving both PwPD and physiotherapists in the development and evaluation of the intervention. The intervention consisted of a walking simulation in three different environments (countryside, city, and park), which had a progressive increase in difficulty. To test its feasibility, three sessions were carried out with four PwPD and four physiotherapists. To assess the usability, the System Usability Scale (SUS), Assistive Technology Usability Questionnaire for people with Neurological diseases (NATU Quest) and Simulator Sickness Questionnaire (SSQ) were used. To assess the intervention's acceptability, feedback and in-game performance was collected from participants.
RESULTS: Results showed the feasibility of the intervention, with a SUS score of 74.82 ± 12.62, and a NATU Quest score of 4.49 ± 0.62, and positive acceptability feedback. Participants showed clear preferences for naturalistic environments, and gamification elements were seen as positive. Difficulty settings worked as intended, but lowered enjoyment of the experience in some cases.
CONCLUSIONS: This intervention was successfully shown as a feasible option for the training of gait under Dual Task conditions for PwPD. It offers a safe and replicable environment in which complex situations can be trained. However, further iterations of the intervention need to be improved in order to guarantee accurate tracking and a more realistic training progression.
TRIAL REGISTRATION NUMBER: NCT05243394-01/20/2022.
Matching placebo (2 tablets) administered twice a day from day 1 through the Week 26 visit, inclusive. All tablets will be self-administered by mouth with water, with or without food.
Depression is a serious condition that can cause significant social and emotional problems and reduce the overall quality of life. Relapses in depressive episodes are common and may result in a patient's reluctance to follow a treatment regimen, thus making the episode more severe. Safe and effective therapies to prevent depression relapse are needed. This study will compare three different approaches to determine which is most effective in preventing relapses in depressive episodes.

This study will comprise 2 parts. In Part 1, all participants will receive antidepressant medication for 6 months. Participants whose depression symptoms do not improve will complete their study participation at the end of Part 1. Participants who respond to their regimen will be enrolled in Part 2. This part will last 18 months. During Part 2, participants will be randomly assigned to one of three groups. Participants in Group 1 will continue the drug regimen they began in Part 1. Participants in Group 2 will discontinue their antidepressants and attend an 8-week relapse prevention program. This MBCT program is designed to help participants learn skills that can increase their awareness and change their reaction to stressful events. Participants in Group 3 will have their antidepressant medication from Phase 1 switched to a placebo without their knowledge. Self-report scales will be used to assess the depressive symptoms of participants at the beginning of the study, at the end of Phase 1, and at the end of the study, after Phase 2.
Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.
PURPOSE:To stably and continuously produce a salt hardly soluble in water which has regular diameters by subjecting a part of a raw material solution to preliminary reaction to form a specific precentage of all the formed salt hardly soluble in water as seed crystals, and next performing the remaining reaction in the presence of the seed crystals. CONSTITUTION:Two kinds or more of raw material solutions are continuously fed into a tubular reactor 7, and mixed and reacted in the reactor to produce a salt hardly soluble in water. Here, 0.01-10mol% of the salt hardly soluble in water of all the formed salt hardly soluble in water is formed as seed crystals by previously subjecting a part of the raw material solutions to preliminary reaction. Next, the remaining raw material solutions are subjected to main reaction in the presence of the seed crystals. Here, the salt hardly soluble in water is defined as barium sulfate. In this way, the salt hardly soluble in water which has regular diameters and is suitable for extender pigment, cosmetics, photographic emulsion, electronic materials, additives, etc., is produced. And the yield of the salt having the desired particle diameters is improved, the seed crystals are prepared, and ancillary facilitates accompanying it are reduced.
The invention discloses quick-acting fracture setting medicine powder which comprises the following components proportioned by mass: native copper 12-20%, teasel root 12-25%, galium aparine 16-25%, nux vomica 12-20%, crab 25-50%, ophisaurus harti boulenger 12-25%, sambucus williamsii 16-25%, woodlouse 12-25%, pseudo-ginseng 12-30%, helleborus thibetanus 12-30%, and leech 12-25%. The preparation method of the quick-acting fracture setting medicine powder disclosed by the invention comprises the following steps: weighing the 11 traditional Chinese medicines according to the proportion specified in the formula; drying; uniformly mixing, grinding into fine powder by using a grinder; and finally uniformly mixing to obtain the quick-acting fracture setting medicine powder. The quick-acting fracture setting medicine powder disclosed by the invention is externally applied by the following steps: setting the fracture part of a patient in right place; mixing the needed dosage of the medicine powder with liquor with the concentration more than 50 DEG to prepare the medicine paste; applying the medicine paste to the fracture part of the patient; and wrapping the part with bandage. The quick-acting fracture setting medicine powder disclosed by the invention is put into clinic application, has obvious treatment effects and can be used for the quick fracture setting of open fracture and comminuted fracture. The pain of the patient can be relived in a short time, and the functions of the limbs can be rapidly recovered. The quick-acting fracture setting medicine powder disclosed by the invention is suitable for the patients with fracture caused by various external reasons.
Participants randomized into the Intensive BP Control arm will have a goal of home SBP \<120mmHg. For most participants in the Intensive Group, a two- or three-drug regimen should be initiated at randomization. Following the randomization visit, addition of another drug or medication dose titration is indicated if home SBP is ≥120 mmHg. Monthly visits will continue in the Intensive Group until home SBP \<120 mmHg or no more titration planned. If the home SBP is not \<120 mmHg at the every 6-month visit, then an antihypertensive drug from a class different from what is being taken should be added, rather than up-titration the dosage of previous drugs, unless there are compelling reasons against this practice.
The aim of this randomized control trial is to examine effectiveness of individually tailored web- and mobile-based Acceptance- and Commitment Therapy interventions to promote adolescents' well-being and life-control and subsequently support their successful transition from basic education to upper secondary education. Our additional aim is to examine to what extent the effectiveness of the intervention varies according to intervention intensity and according to risk for school failure. The five-week structured intervention is delivered using the novel web-and mobile-based program Youth COMPASS following the principles of the Acceptance and Commitment Therapy (ACT). The Internet context is assumed to be particularly motivating for youth who enjoy spending time online using different social media. Internet-based interventions have several advantages; they can include more information and treatment components than traditionally delivered treatments and that intervention programs are accessible at any time and at any place. Another unique aspect of the Youth COMPASS is the fact that it is individually-tailored. Each participant have an individually assigned online coach who provides support and encouragement, reminds about Youth COMPASS, sends individualized feedback, and recommends different exercises. The study hypothetizes that the Youth COMPASS is more effective than school counseling as usual. More specifically, the Youth COMPASS is expected to be more effective when it is combined with face-to-face support than when support and feedback are provided only via the Internet. Also, the Youth COMPASS with no face-to-face support (online only) is expected to be more effective than receiving only regular school counseling. Finally, the Youth COMPASS is expected to be more effective for students at risk for school failure than for students without risk for school failure, especially when at risk-adolescents receive more intensive support (i.e., both online and face-to-face support). The participants of the effectiveness study of the Youth COMPASS are selected from the participants of the broader longitudinal STAIRWAY (TIKAPUU in Finnish) - From Primary School to Secondary School study, which follows a community sample of Finnish adolescents (n\~850) across critical educational transitions. The overall aim of the STAIRWAY project is to broaden our understanding of the individual- and environment-related factors that promote learning, well-being and successful educational transitions.
Although many studies have reported auditory complications after spinal, none have been done in obstetric patients with accidental dural puncture with epidural needle. Long term follow up of these complications has been unknown. The incidence of both auditory and visual complications is likely to be high in patients getting accidental dural puncture with 17G Touhy epidural needle as compared to small gauge spinal needles. Several case reports have been reported with such temporary and permanent hearing and visual loss. A prospective study to understand these complications is required. The study will provide us with the true incidence of audiovisual complications of dural puncture with an epidural needle. Early intervention in cases of dural puncture may alleviate or halt symptoms.
The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
Participants in the steady state condition will begin the intervention with a gradual one minute warm up effort with a ramp in the resistance gradually increasing from 0 watts to 70% of their Wpeak over 1 minute. They will then continue at this resistance level at a freely chosen cadence for 5 minutes, after which they will gradually warm-down to 0 watts over 1 minute.
PROBLEM TO BE SOLVED: To easily prepare a readily water-dispersible oil-added formulation contg. an oil component at a high concn. and having stability over a long period of time by adding the oil component to an O/W emulsion contg. an emulsified and dispersed oil-soluble sucrose fatty acid ester. SOLUTION: The O/W emulsion contg. an emulsified and dispersed oil-soluble sucrose fatty acid ester is an aq. emulsion contg. about 1-50 wt.%, preferably about 5-40 wt.% oil-soluble sucrose fatty acid ester. The oil-soluble sucrose fatty acid ester is preferably the ester of an about 6-22C fatty acid and sucrose and the HLB of the ester is <=7, preferably about <=5. The oil component added to the aq. emulsion is a water-insoluble oil material selected from a wide range and is not particularly limited. The weight ratio of the oil component to the oil-soluble sucrose fatty acid ester is 0.1-5, preferably about 0.5-3.
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that affects nearly 3.41 million people globally, with 90% of the cases affecting women of childbearing age. SLE is a complex disease due to the interplay of various immunological pathways and mechanisms. This scoping review aims to highlight the latest research findings on the therapeutic mechanisms of action of EVs in SLE. Relevant research articles were identified using the PRISMA framework from databases such as PubMed/MEDLINE (National Library of Medicine), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) from July 2023 to October 2023. Eleven studies met the inclusion criteria and thus were included in this scoping review. The findings showed that EVs have therapeutic effects on ameliorating the disease progression of SLE. EVs can reduce the pro-inflammatory cytokines and increase the anti-inflammatory cytokines. Moreover, EVs can increase the levels of regulatory T cells, thus reducing inflammation. EVs also have the potential to regulate B cells to alleviate SLE and reduce its adverse effects. The scoping review has successfully analysed the therapeutic potential in ameliorating the disease progression of SLE. The review also includes prospects to improve the effects of EVs further to increase the therapeutic effects on SLE.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to pharmaceutical and chemical industry, particularly to a method of preparing pakistan amine and berberine chloride. The method of preparing pakistan amine and berberine chloride by extraction of Siberian barberry (Berberis sibirica Pall.) roots with organic solvents (ethanol, methanol, acetone, and also their mixtures with water) followed by separation of a precipitate and pakistan amine sedimentation by a concentrated ammonia solution and pakistan amine purification by aluminium oxide column chromatography and further berberine chloride sedimentation from the remained filtrate by concentrated hydrochloric acid, with recrystalliszation purification of the settle down salt. ^ EFFECT: method allows higher yield of Siberian barberry alkaloids - pakistan amine and berberine chloride. ^ 5 ex
This study aimed to investigate the changes of gut microbiota and allergic inflammation in mice with allergic enteritis caused by milk protein. In this study, female BALB\C mice in the whey protein (WP-sensitized) group were gavaged with WP and normal saline, the sham-sensitized group was given normal saline once a week for 5 weeks. One week later, the WP-sensitized mice were administered 60 mg β-lactoglobulin (BLG). The results showed that mice's body weight decreased, feces with loose and bloody, and systemic allergic reactions and ear swelling increased in the WP-sensitized group. The levels of WP-specific Ig, mMCP-1, calprotectin of feces, and inflammation-related factors in the WP-sensitized group were increased. WP-sensitized group intestine tissues were damaged severely and the expressions of ZO-1, Claudin-1, and Occludin reduced. The results of 16S rRNA sequencing showed that there were differences in operational taxonomic units (OUT) levels of gut microbes between the two groups, o_Clostridiales, c_Clostridia, and f_Lachnospiraceae were more abundant in the WP-sensitized group. In conclusion, the WP sensitization can induce the allergic inflammation, intestinal injury and intestinal barrier dysfunction in mice, and the gut microbes were also changed, which provided a reference for the treatment of WP-sensitized mice.
The qualification for phrenectomy in group 1 will be made based on the Amir scale, i.e. a score of 4 and fewer points for the language function.
Skin test device has a film backing. The film backing is made of silicone, and is marked off into divisions by grooves. The divisions each have a different sample containing a suspected allergen. The film backing has a see-through feature and the condition of the skin can visually be checked when the film backing is staying on the skin. The divisions are easily separable from each other. When certain samples cause significant allergic reactions, the divisions corresponding to those samples can be removed immediately.