anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Our study aimed to provide consensus and expert clinical practice statements related to airway management in critically ill adults with a physiologically difficult airway (PDA).
METHODS: An international Steering Committee involving seven intensivists and one Delphi methodology expert was convened by the Society of Critical Care Anaesthesiologists (SOCCA) Physiologically Difficult Airway Task Force. The committee selected an international panel of 35 expert clinician-researchers with expertise in airway management in critically ill adults. A Delphi process based on an iterative approach was used to obtain the final consensus statements.
RESULTS: The Delphi process included seven survey rounds. A stable consensus was achieved for 53 (87%) out of 61 statements. The experts agreed that in addition to pathophysiological conditions, physiological alterations associated with pregnancy and obesity also constitute a physiologically difficult airway. They suggested having an intubation team consisting of at least three healthcare providers including two airway operators, implementing an appropriately designed checklist, and optimizing hemodynamics prior to tracheal intubation. Similarly, the experts agreed on the head elevated laryngoscopic position, routine use of videolaryngoscopy during the first attempt, preoxygenation with non-invasive ventilation, careful mask ventilation during the apneic phase, and attention to cardiorespiratory status for post-intubation care.
CONCLUSION: Using a Delphi method, agreement among a panel of international experts was reached for 53 statements providing guidance to clinicians worldwide on safe tracheal intubation practices in patients with a physiologically difficult airway to help improve patient outcomes. Well-designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties.
A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.
A traditional Chinese medicine for treating diabetes relates to the technical field of Chinese herbal medicines. The traditional Chinese medicine comprises the following bulk drugs: by weight, 25-35 parts of rhizoma atractylodis, 25-35 parts of rhizoma alismatis, 25-35 parts of Polygonum aviculare, 5-15 parts of radix aconiti lateralis preparata, 55-65 parts of astragali radix, 15-25 parts of Cornus officinalis, 5-15 parts of cassia twig, 25-35 parts of plantago, 5-15 parts of red sage root and 1-10 parts of lotus leaf. Selection and compatibility of traditional Chinese medicinal materials accord with dialectical theories in Chinese Medicine, and a preparation method of the traditional Chinese medicine is simple. After compatibility, a water decoction is prepared. The traditional Chinese medicine has a remarkable effect of treating hyperglycemia animal models and diabetic patients and has no toxic or side effect. Complementary purpose in traditional Chinese medicine compatibility is achieved.
Described herein is a moisturizing and nutritional cream, which is a 100% natural, dense and moisturizing composition providing nutrients to skin, and ideal for both young and aged skins. The cream includes components that provide flexibility to skin, thus forming a natural barrier for avoiding losing excessive amounts of water. The invention may act as a highly effective anti-aging treatment which responds to the day-to-day needs of skin. The composition has a natural essence for maintaining the properties thereof, it is 100% natural, useful for normal to dry skin, and applied in face and neck, the same being useful for preventing and reducing the formation of wrinkles, and extending the softness and youth in young skins by forming a barrier that avoids evaporation, said cream also recovering and extending softness and youth in aged skins. The inventive cream may be applied to aged, dried and de-vitalized skins, the components thereof providing a flexible and smooth appearance. The e ffectiveness of the present invention has been tested on young and aged skins.
PROBLEM TO BE SOLVED: To obtain a bleaching preparation exhibiting an excellent melanin generation-suppressing effect caused from a multiplier effect, accelerating ejection of melanin pigment and exhibiting an excellent beauty white effect in a short time by including a specific glucoside and a placenta extract. SOLUTION: This bleaching preparation contains (A) a glucoside [e.g. raspberry ketone-D-glucoside (α-body and β-body)] of the formula (R is a sugar residue selected from monosaccharide and disaccharide) and (B) a placenta extract (e.g. water-soluble placenta extract). Preferably, a formulation amount of the component A is 0.01-10.0 wt.%. preferably, a formulation amount of the component B is 0.01-30 wt.% in a total amount of the cosmetic. Preferably, further N-methyl-L-serine in an amount of 0.001-3 wt.% and water-soluble ascorbic acid derivative in an amount of 0.001-30 wt.%, respectively based on a total amount of the cosmetic are formulated. By the process, an excellent bleaching preparation can be provided.
This invention describes the new 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives of general formula I, in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6 R7, A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (psoriasis, arthritis). To avoid uncontrolled proliferation of cells and for better compatibility of medical implants, they can be applied or introduced into the polymer materials. The compounds according to the invention can be used alone or to achieve additive or synergistic actions in combination with other principles and classes of substances that can be used in tumor therapy.
<P>PROBLEM TO BE SOLVED: To provide an MMP-8 inhibitor, to improve various symptoms of diseases induced by production or increased activity of MMP-8, and to provide a prophylaxis or a therapy for the diseases.  <P>SOLUTION: A novel finding that cysteines (e.g. L-cysteine) inhibit matrix metalloproteinase-8 has been obtained. The matrix metalloproteinase-8 inhibitor contains the cysteines as active ingredients. A prophylactic or therapeutic composition for periodontal diseases in diabetic patients or persons with impaired glucose tolerance contains the matrix metalloproteinase-8 inhibitor.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Aromatic formulation for perfumed products and cosmetic compositions, obtaining and using procedure. The present invention relates to an aromatic formulation characterized in that it comprises an alcoholic base of wine qualified under the rioja designation of origin and different vegetable oils, extracted both from by-products of the elaboration of said wine and from plant biological material from vines covered by the denomination of rioja origin, being able also to come from other autochthonous species of plants and trees. The present invention also comprises any perfumed product obtained from said formulation, especially the cosmetic compositions, as well as the process for obtaining both, formulation and perfumed product. Said method of obtaining the formulation is characterized in that it is macerated in barrels previously used for the production of wine with the rioja wine designation. Also, the use of the formulation for the manufacture of perfumed products, such as cosmetic compositions, is another object of the present. (Machine-translation by Google Translate, not legally binding)
This study is a single-center, observational, non-interventional, prospective study. 50 patients diagnosed with lung squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy (ranging 2 to 4 cycles) will be planned to be enrolled in the study. Pre-treatment biopsy tissues of enrolled patients will be collected for whole exon sequencing (WES) testing, and personalized detection panel will be customized based on WES testing results. Peripheral blood will be collected 1 day before each cycle of neoadjuvant therapy, 1 day before surgery, 3 days after surgery, and 3 weeks after surgery for ctDNA testing. In addition, the prediction model of AI-based pathology will be constructed by AI deep learning based on pathological sections of pre-treatment biopsy tissues. All inclued patients will be regularly followed up for at least 5 years.
Of the 750,000 strokes in the United States every year, 15% patients suffer from hemorrhagic stroke. Intracerebral hemorrhage (ICH) is a subtype of hemorrhagic stroke. Despite advances in acute management, patients with hemorrhagic stroke continue to suffer from high mortality and survivors suffer from multidomain impairments in the physical, cognitive, and mental health domains which could last for months to years from their index stroke. Long-term prognosis after ICH is critically dependent on the quality and efficacy of care a patient receives during the acute phase of care. With ongoing care consolidation in stroke systems of care, the number of ICH patients who need to undergo interhospital transfers (IHTs) is increasing. However, the associations between IHT and ICH outcomes have not been well described in literature. In this review, we describe the epidemiology of IHT for ICH, the relationship between IHT and ICH patient outcomes, and proposed improvements to the IHT process to ensure better long-term patient outcomes. Our review indicates that evidence regarding the safety and benefit of IHT for ICH patients is conflicting, with some studies reporting poorer outcomes for transferred patients compared to direct admissions via emergency rooms and other studies showing no effect on outcomes. The American Heart Association guidelines for ICH provide recommendations for timely blood pressure control and anticoagulation reversal to improve patient outcomes. The American Heart Association stroke systems of care guidelines provide recommendations for transfer agreements and but do not provide details on how patients should be managed while undergoing IHT. Large, prospective, and multicenter studies comparing outcomes of IHT patients to direct admissions are necessary to provide more definitive guidance to optimize IHT protocols and aid clinical decision-making.
Patients allocated in the intervention group (n=15) received 4 high-protein shakes and the corresponding standard vitamin-mineral (VM) supplementation according to our post BS protocol, then progressed towards a diet that combines traditional foods with 2 hLF shakes per day and VM supplementation for 15 days. Over the following 15 days, patients continued to normalize their diet, including a single hLF shake per day and continued with VM supplementation.
PCT No. PCT/US90/01768 Sec. 371 Date Nov. 25, 1992 Sec. 102(e) Date Nov. 25, 1992 PCT Filed Mar. 30, 1990 PCT Pub. No. WO91/15215 PCT Pub. Date Oct. 17, 1991.The invention relates to fluid resuscitation of the human or animal body by administration of deferoxamine (DFO) and a water-soluble biopolymer. The DFO and the biopolymer are preferably bonded together. The biopolymer may be a polysaccharide or a protein. The DFO and the biopolymer are preferably formulated as an aqueous solution suitable for oral administration. The fluid resuscitation may be effected for ameliorating systemic oxidant injury occurring during ischemia and subsequent reperfusion. The fluid resuscitation may be indicated in treatment of burn injury, lung injury caused by inhalation of hot and/or toxic substances, such as smoke derived from combustion, hemorrhagic shock and other types of trauma.
Skin ageing is a multifaceted process impacted by both intrinsic and extrinsic factors. Drier and less elastic skin with declining sebum levels in older age makes ageing skin more vulnerable to various skin conditions, including infections, inflammatory dermatoses, and cancers. Skin problems are common among older adults due to the effects of ageing, polypharmacy and multimorbidity impacting not only physical health but wellbeing and quality of life. In the UK, older adults in geriatric medicine wards may present with various skin conditions. Hospitalised older individuals may have undiagnosed skin problems unrelated to their admission, making hospitalisation an opportunity to manage unmet needs. Asteatotic eczema, incontinence associated dermatitis, seborrhoeic dermatitis, chronic venous insufficiency, and cellulitis are common disorders clinicians encounter in the geriatric medicine wards. This article outlines the importance of performing comprehensive skin assessments to help diagnose and commence management for these common conditions.
Data for the needs assessment and pilot trial will be collected from the patients via validated surveys, qualitative methods (e.g., interviews and focus groups), and medical record abstraction.

The study will utilize a Hybrid Effectiveness-Implementation design that will blend both a new intervention to impact the effectiveness of hydroxyurea, text messaging, and study its potential for adoption and dissemination in "real-world" practice settings. In Phase I (formative process evaluation), actionable barriers of hydroxyurea adherence in Memphis, Tennessee, will be identified. The investigators will begin by conducting a broad evaluation of hydroxyurea utilization, impediments and facilitators of hydroxyurea adherence and care management in general for patients with SCD. Next, this information will be merged with patients' preferences for the content of an mHealth intervention, and test it in a local cohort (Phase II). If successful and approved by the Sickle Cell Disease Implementation Consortium (SCDIC) executive committee, this intervention will advance to the next phase, namely, the dissemination and implementation in a larger geographical area (the other SCDIC participating sites in Phase III). We will utilize the RE-AIM framework to evaluate the intervention representativeness and impact during all phases.
Lapatinib 1250 mg once daily plus capecitbine daily dose divided and given twice daily orally, for 14 days, every 21 days. The capecitabine starting dose for the combination arm was 2000 mg/m2.
The pericoronary fat attenuation index (FAI), which capture by standard coronary computed tomography angiography (CCTA), has emerged as a novel imaging biomarker of coronary inflammation. This study aimed to assess whether increased Pericoronary FAI on CCTA are associated with high-risk plaque (HRP) feature as well as local T cell subsets and their intracellular cytokines levels in non-ST elevation acute coronary syndromes ( ACS) patients. 195 lesions in 130 non-ST elevation ACS patients were prospectively enrolled and evaluated by CCTA and coronary angiography in this study. Blood were taken from coronary artery immediately after the diagnostic angiogram. Local T cell subsets and their intracellular cytokines levels were detected by Flow Cytometry. CCTA and pericoronary FAI examinations were performed using a 320-detecor (Aquilion ONE, Toshiba Medical Systems, Otawara, Japan) Systems. Coronary plaque characteristics were analyzed cross each of the main coronary arteries using commercialized software package (Qangio CT, Medis, The Netherlands).
This is a randomized feasibility and acceptability study using a block generator for randomization of participants aged 15 to 21 into either in-person parenting education or on-line parenting. Outcome measures include parenting self-efficacy and participation in daily parenting activities. Participants will take part in approximately twelve hours of parenting education, whether in-person or on-line. Recruitment flyers will be placed in two primary care clinics and a large regional hospital's Labor \& Delivery and Postpartum (Mother-Baby) Units. Participants will seek out the opportunity to participate by calling the phone number or sending an e-mail to the investigators to learn more about the study and their potential participation. If participants meet eligibility criteria and elect to participate, baseline measurements will be completed after enrollment, with follow-up measures at one month and two months.
To prevent catfish idiopathic anaemia, diets fortified with iron have been adopted as a regular practice on commercial catfish farms to promote erythropoiesis. However, the effects of prolonged exposure of excess dietary iron on production performance and disease resistance for hybrid catfish (Ictalurus punctatus × I. furcatus) remains unknown. Four experimental diets were supplemented with ferrous monosulphate to provide 0, 500, 1000, and 1500 mg of iron per kg of diet. Groups of 16 hybrid catfish juveniles (~22.4 g) were stocked in each of 20, 110-L aquaria (n = 5), and experimental diets were offered to the fish to apparent satiation for 12 weeks. At the end of the study, production performance, survival, condition indices, as well as protein and iron retention were unaffected by the dietary treatments. Blood haematocrit and the iron concentration in the whole-body presented a linear increase with the increasing the dietary iron. The remaining fish from the feeding trial was challenged with Edwardsiella ictaluri. Mortality was mainly observed for the dietary groups treated with iron supplemented diets. The results for this study suggest that iron supplementation beyond the required levels does affect the blood production, and it may increase their susceptibility to E. ictaluri infection.
Cardiac surgery may lead to myocardial damage and release of cardiac biomarkers through various mechanisms such as cardiac manipulation, systemic inflammation, myocardial hypoxia, cardioplegic arrest and ischaemia caused by coronary or graft occlusion. Defining perioperative myocardial infarction (PMI) after cardiac surgery presents challenges, and the association between the current PMI definitions and postoperative outcomes remains uncertain. To address these challenges, the European Association of Cardio-Thoracic Surgery (EACTS) facilitated collaboration among a multidisciplinary group to evaluate the existing evidence on the mechanisms, diagnosis and prognostic implications of PMI after cardiac surgery. The review found that the postoperative troponin value thresholds associated with an increased risk of mortality are markedly higher than those proposed by all the current definitions of PMI. Additionally, it was found that large postoperative increases in cardiac biomarkers are prognostically relevant even in absence of additional supportive signs of ischaemia. A new algorithm for PMI detection after cardiac surgery was also proposed, and a consensus was reached within the group that establishing a prognostically relevant definition of PMI is critically needed in the cardiovascular field and that PMI should be included in the primary composite outcome of coronary intervention trials.
Mastalgia is encountered in 70% of premenopausal women and is one of the most frequent reasons for attending general surgery clinics. In most of the cases no physical cause is demonstrated and the etiopathogenesis is still not yet determined. In 1949 Patey, for the first time, proposed that mastalgia might be a psychologically based problem. In the following years, research was focused in this issue and some articles were published demonstrating the relationship of anxiety, depression and high stress levels with mastalgia. The efforts for finding out the etiopathologic mechanism and defining the risk factors revealed that smoking and consumption of tea, coffee and carbonated beverages in particular worsen mastalgia whereas essential fatty acids (especially gamma linoleic acid) provides a symptomatic relief. Additionally it is known that sleep irregularities cause serious deterioration in daily life quality as well as can exaggerate some medical, neurologic and/or psychiatric conditions. More than half of the population experience sleep irregularities from time to time and chronic sleep disturbances effect 20% of adult population in western countries. Therefore sleep irregularities might have contributing effects in the etiopathogenesis and/or symptomatology of therapy resistant conditions like mastalgia.
Method comprises placing a prod. based on natural incense in the outer auditory tract of the ear and allowing the incense to release its characteristic perfume. Pref. commercially available incense balls are placed in each ear and left there for several hours, esp. overnight. ADVANTAGE - The method is non-invasive and causes no side effects.
PURPOSE:An antibacterial agent for man and animal comprising naphtho[2,3-d] thiazol-4,9-dione as an active ingredient. CONSTITUTION:A drug containing a compound shown by the formula as an active ingredient, showing strong antibacterial activity not only against microplasma but also against Gram-positive and Gram-negative bacteria. A dose is 5-1,000mg/day/person, preferably 10-500mg/day/person, it is administered orally or parenterally. Another antibacterial agent can be added to the dosage form of it. Powder, fine granule, granule, tablet, capsule, injection, etc, are used as the dosage form. In administering it to animal such as cattle, domestic fowl, etc., it is medicated orally or parenterally. Oral administration is usually carried out by adding it to a feed. The compound shown by the formula has extremely low toxicity, so it has extremely high safety, can be successively administered for a long period, at low cost.
Carcinogenicity studies have not been performed with glasdegib.

Glasdegib was not mutagenic in vitro in the bacterial reverse mutation (Ames) assay and was not clastogenic in the in vitro chromosome aberration assay in human lymphocytes. Glasdegib was not clastogenic or aneugenic in the rat micronucleus assay.

Based on nonclinical safety findings, glasdegib has the potential to impair reproductive function in males. Men should seek advice on effective fertility preservation before treatment. In repeat-dose toxicity studies in rats, findings observed in the male reproductive tract included adverse testicular changes with glasdegib at doses ≥50 mg/kg/day, and consisted of minimal to severe hypospermatogenesis characterized by partial to complete loss of spermatogonia, spermatocytes and spermatids and testicular degeneration. Hypospermatogenesis did not recover whereas testicular degeneration did recover. The dose at which testicular effects were observed in male rats was identified as 50 mg/kg/day with corresponding systemic exposures that were approximately 6.6-times (based on AUC) those associated with the observed human exposure at the 100 mg once daily dose.