anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject substance comprising deferoxamine and effective for the therapy of wounds. SOLUTION: This substance for treating wounds comprises deferoxamine of formula I (R' is a group of formula II) or its salt. A wound-treating medicine contains the wound-treating substance in an amount of 10<-5> to 50wt.% as an active ingredient. The compound of formula I is obtained by culturing a deferoxamine-producing strain belonging to the genus Streptomyces or by a synthetic method. The medicine is administered at a daily dose of 10ng to 1g/Kg as the wound-treating substance with one to four portions. Although the wounds of surface tissues are generally refractory, and can sufficiently not be cured with existing medicines, the medicine containing the compound of formula I is highly effective.
The fascial fitness® method (12 sessions, twice a week, for six weeks, 15 minutes a day, for 2 sets of 40 seconds each side). Assessments and reassessments will be carried out in the first, fourth and sixth week.
The How-to Parenting Program consists of seven 2 ½-hour weekly sessions. It is a manual-based program in which participants have their own exercise booklet containing parenting skills and exercises. Groups are led by 2 group leaders and formed of 6 to 10 parents.
Thiotepa for injection should be reconstituted with 1.5 mL of sterile water for injection resulting in a drug concentration of approximately 10 mg per mL. The actual withdrawable quantities and concentration achieved are illustrated in the following table: 

The reconstituted solution is hypotonic and should be further diluted with sodium chloride injection (0. 9% sodium chloride) before use. 

When reconstituted with sterile water for injection, solutions of thiotepa should be stored in a refrigerator and used within 8 hours. Reconstituted solutions further diluted with sodium chloride injection should be used immediately. 

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. 

In order to eliminate haze, filter solutions through a 0.22 micron filter* prior to administration. Filtering does not alter solution potency. Reconstituted solutions should be clear. Solutions that remain opaque or precipitate after filtration should not be used.

*Polysulfone membrane (Gelman's Sterile Aerodisc®, Single Use) or triton-free mixed ester of cellulose/PVC (Millipore's MILLEX®-GS Filter Unit).
Background: Status epilepticus (SE) is a series of seizures that can lead to serious neurological damages. Cannabidiol (CBD) is extracted from the cannabis plant, which has been approved as an antiseizure medication. This study aimed to determine the efficacy of various doses of CBD on lithium-pilocarpine-induced SE in rats and possible involvement of multiple pharmacological pathways. We hypothesized that cannabinoid receptors type 1 (CB1) and CB2, as well as GABAA receptors, might have important roles in the anticonvulsant effects of CBD against SE by its anti-inflammatory effects. Methods: SE was induced by intraperitoneal (i.p.) injection of lithium (127 mg/kg, i.p.) and pilocarpine (60 mg/kg, i.p., 20 h after lithium). Forty-two male rats were divided into seven groups (including control and sham groups), and the treated groups received different doses of CBD (1, 3, 5, 10, and 25 mg/kg, i.p.). SE score was recorded over the next 2 h following pilocarpine injection. Then, we measured the levels of pro-inflammatory cytokines, including interleukin (IL)-lβ and tumor necrosis factor (TNF)-α, using ELISA kits. Also we analyzed the expression of CB1, CB2, and GABAA receptors using the Western blot technique. Results: CBD at 5 mg/kg significantly reduced Racine's scale and duration of seizures, and increased the onset time of seizure. Moreover, CBD 5 mg/kg caused significant reductions in the elevated levels of IL-lβ and TNF-α, as well as a significant increase in the decreased level of CB1 receptor expression compared to the control group. In other word, CBD reverted the effects of SE in terms of neuroinflammation and CB1 receptor. Based on the obtained results, CBD was not able to restore the declined levels of CB2 or GABAA receptors. Conclusion: Our study found anticonvulsant effects of CBD on the SE rat model induced by lithium-pilocarpine with probable involvement of CB1 receptors and anti-inflammatory effects by reducing IL-1β and TNF-α markers independent of CB2 and GABAA receptors.
A method of tracking and dispensing the dispense of medical items for use by patients associated with a health care institution, includes storing in a data store in connection with a computer, data representative of patients and medical items prescribed for the patients. Authorized users such as nurses, are enabled to dispense prescribed items for patients through medical item dispensers. A record is included in the data store that the medical items have been dispensed. In an exemplary system ( 650 ) medical items that have been dispensed are tracked to the point of giving the item to the patients using portable terminals ( 662 ) that are carried to the bedside of the patients. The activity of giving the appropriate medical item to each respective patient is recorded in the portable terminal as medical items are given to a plurality of patients. The data stored in the portable terminal concerning the giving of medical items to patients is communicated through the system and stored in the data store to provide a record that the medical items which were dispensed for a patient, were actually administered.
BACKGROUND: To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients.
METHODS: The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data.
RESULTS: In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (P < 0.05), but the percentage of CD8+ increased (P < 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (P < 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (P < 0.05 and P < 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (P < 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels.
CONCLUSIONS: Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. In summary, sufficient levels of Vitamin D may lead to a sustained virological response that is debatable by artificially correcting the deficiency.
According to standard Guideine of videofluoroscopic swallow study(VFSS), Patients referred to dysphagia(swallowing dysfunction)who were required to tube feeding and medically stable of vital sign, and agreed to participate. Participants with swallowing dysfunction who were classified into three groups (nasogastric tube, traditional intermittent (IOE) tube, individual 3D printed guiding tube) according to VFSS.

Both traditional IOE tube and individual 3D printed guiding tube groups will receive training about procedure prior to the first feeding. All participants will be evaluated with satisfaction for tube feeding (EORTC QLQ-H\&N35) in 3 days from the start day of the tube feeding. On the day of oral feeding, participants will be evaluated with the questionnaires and clinical examination. If the participant is discharged in a state maintain the tube feeding, investigated further length stay at leaving the hospital. On the 1 month, 3 month from tube feeding, the investigators will follow-up and measure the questionnaires and clinical examination.
Postoperative bacterial infections are prevalent complications in both human and veterinary orthopedic surgery, particularly when a biofilm develops. These infections often result in delayed healing, early revision, permanent functional loss, and, in severe cases, amputation. The diagnosis and treatment pose significant challenges, and bacterial biofilm further amplifies the therapeutic difficulty as it confers protection against the host immune system and against antibiotics which are usually administered as a first-line therapeutic option. However, the inappropriate use of antibiotics has led to the emergence of numerous multidrug-resistant organisms, which largely compromise the already imperfect treatment efficiency. In this context, the study of bacterial biofilm formation allows to better target antibiotic use and to evaluate alternative therapeutic strategies. Exploration of the roles played by mechanical factors on biofilm development is of particular interest, especially because cartilage and bone tissues are reactive environments that are subjected to mechanical load. This review delves into the current landscape of biofilm mechanobiology, exploring the role of mechanical factors on biofilm development through a multiscale prism starting from bacterial microscopic scale to reach biofilm mesoscopic size and finally the macroscopic scale of the fracture site or bone-implant interface.
Four consecutive weeks with CPAP C- FLEX PLUS treatment. After these 4 weeks, patients will undergo full PSG with CPAP FLEX- PLUS. Patients will also fill out Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Functional Outcome Sleep Questionnaire, and visual analogue scale assessing CPAP side effects and patient´s comfort. Adherence to 4-week treatment will be checked. Treatment is followed by 7-day washout period.
This is a prospective observational study. We are comparing the agreement between a virtual video airway evaluation and an inpatient person-to-doctor airway assessment.

Patients will be referred for virtual preoperative assessment clinic by the gynaecology outpatient department based on inclusion criteria and a patient information leaflet and consent form is supplied at this time. During the virtual assessment consent is taken, followed by a standard history and airway examination. The airway assessment will be performed by an investigator of \>5 years anaesthetic experience and will have to undergo a standardised airway assessment training. This airway evaluation is also documented separate to the remainder of the history, sealed in an envelope and labelled a designated number. On the date of surgery, the patient is assessed again by an investigator in the ward/theatre prior to surgery. This airway examination is documented on the standard anaesthetic record sheet as well as on a separate in-person evaluation form. This airway assessment form is then sealed in an envelope and labelled the same designated number as the virtual assessment. The evaluations will be entered into a database and analysed.

If the evaluation is found to show predictors of a difficult airway in the virtual clinic, the patient is scheduled for an in-person outpatient appointment. The airway is then assessed by an investigator in-person at the clinic. The airway is then assessed by an anaesthetic consultant and documented on the anaesthetic record sheet. Investigators will have no further involvement in the clinical management of the patient.
The use of physiologically acceptable salts of 6-amino-6-deoxy-L-sorbofuranose of formula (I) (where HX is a physiologically acceptable acid) for inhibiting glucosidases in the digestive tract is new. (I) are esp. useful for inhibiting alpha-glucosidases, specifically saccharases, and are formulated in usual pharmaceutical compsns. (I) are claimed for treatment of adiposity, diabetes and hyperlipoproteinaemia in humans and animals, and for reducing fat accumulation while increasing lean meat prodn. and improving feed utilisation in animals. Other uses are treatment of pre-diabetic states, gastritis, constipation, caries and atherosclerosis.
Intervertebral disc disease, a prevalent ailment, frequently leads to intermittent or persistent low back pain, and diagnosing and assessing of this disease rely on accurate measurement of vertebral bone and intervertebral disc geometries from lumbar MR images. Deep neural network (DNN) models may assist clinicians with more efficient image segmentation of individual instances (discs and vertebrae) of the lumbar spine in an automated way, which is termed as instance image segmentation. In this work, we proposed SymTC, an innovative lumbar spine MR image segmentation model that combines the strengths of Transformer and Convolutional Neural Network (CNN). Specifically, we designed a parallel dual-path architecture to merge CNN layers and Transformer layers, and we integrated a novel position embedding into the self-attention module of Transformer, enhancing the utilization of positional information for more accurate segmentation. To further improve model performance, we introduced a new data synthesis technique to create synthetic yet realistic MR image dataset, named SSMSpine, which is made publicly available. We evaluated our SymTC and the other 16 representative image segmentation models on our private in-house dataset and public SSMSpine dataset, using two metrics, Dice Similarity Coefficient and the 95th percentile Hausdorff Distance. The results indicate that SymTC surpasses the other 16 methods, achieving the highest dice score of 96.169 % for segmenting vertebral bones and intervertebral discs on the SSMSpine dataset. The SymTC code and SSMSpine dataset are publicly available at https://github.com/jiasongchen/SymTC.
A face mask containing rhizoma polygonati stem cells and lycopene liposomes comprises a mask liquid and a mask paper, wherein the mask liquid consists of the following components by taking the total weight of the mask liquid as a reference: 4-8 wt% of polygonatum sibiricum stem cell essence, 2-4 wt% of ginseng and 1-4 wt% of vitamin E nicotinate; 1-2 wt% lycopene; 1 to 2 weight percent of PQQ cyclodextrin loaded nano-liposome and 0.5 to 2 weight percent of VC acetate. Wherein, the lycopene is chitosan loaded nano liposome, and other components of the mask liquid are matrix and purified water. The invention also discloses a preparation method of the mask containing the polygonatum stem cells and the lycopene liposome. The invention can effectively improve the skin. Has antiaging and elasticity enhancing effects, and is effective for moistening skin, activating skin, resisting aging, resisting oxidation, and repairing cell tissue. The high-efficiency stem cell mask can deliver effective ingredients into the skin, and can make the skin surface wrinkle fade, the skin compact, smooth and glossy after being used.
PURPOSE:A toothache sedative capable of rapidly, excellently and durably allaying activity and excitement of a pain of dental pulp only by applying the sedative to the surface of dentin, containing N-methacryloylaminosalicylic acid an active ingredient. CONSTITUTION:A toothache sedative containing N-methacryloylamino-salicylic acid is impregnated into sponge, sanitary cotton, etc., applied to the surface of dentin to alloy activity and excitement of perception erethism of dental pulp. In the procedure, in order to exhibit duration time, further an unsaturated group-containing compound (e.g. methyl methacrylate, triethylene glycol dimethacrylate, etc.) is preferably copolymerized with N- methacryloylaminosalicylic acid to form a film. It also has effective action on bonding to dental adhesive resin, restorative composite resin, etc., on the market and makes much progress on remedy for dental caries, etc.
Second dose is given 21 days after the initial dose. The same dose and route of administration are used.
Participants enrolled in this cohort will receive BBO-10203 tablets orally QD in combination with trastuzumab IV (8mg/kg over 90 minutes on Cycle 1 Day 1, 6mg/kg over 30-90 minutes during subsequent cycles)/SC (600mg). This cohort will enroll patients with advanced breast cancer.
Maternal opioid use disorder (OUD) is the leading cause of maternal mortality in the first year after delivery nationwide. OUD also contributes substantially to out-of-home placements in the child welfare system. Medication for OUD (MOUD) is the primary standard of treatment, however, access to MOUD and prenatal care is limited, siloed, and fragmented in Florida. Gaps in access to and continuity of healthcare (prenatal, postpartum, pediatric, pharmacological and behavioral health) and other services for mothers in OUD recovery lead to poor outcomes for parent, child and family. There is also insufficient data integration, due to inconsistent data collection methods or use of diagnostic codes, to identify mother-infant dyads affected by OUD that could inform optimal care at the local level. Single-site studies that integrate substance use disorder programs in pregnancy have been shown to improve neonatal and maternal outcomes. With that in mind, the long-term goal of this study is to leverage high-quality local and timely data to improve OUD outcomes before, during, and after pregnancy with an integrated care approach that can be replicated throughout the state. The objective of the proposed project is to consolidate multiple streams of public health and clinical healthcare data to analyze equitable access and outcomes for families affected by maternal OUD for use in quality improvement cycles to rapidly refine our integrated CADENCE (Continuous and Data-Driven Care) Program. Our central hypothesis is that integrated, continuous, data-driven care will improve CADENCE patient outcomes. We will test this hypothesis through the following aims: 1) create an interactive data dashboard for maternal, neonatal, and infant outcomes for pregnancies affected by OUD; 2) pilot the CADENCE program and rapidly refine using a data-driven approach.
Hyperostosis happens slowly without general symptom and happens to middle-aged and elderly people being 50 years old or older. The disease often happens at joints, and the joint can also happen to a single joint. An involved joint has dull pain, and the dull pain can be intensified by frequent activity and can be relieved after a rest. The pain is not severe generally, can be intensified in low atmospheric pressure and is involved with climatic change. In later stages, the joint can be swelled, enlarged and limited from action, is barely completely rigid and has the symptom of bone retardation. The medicine is prepared from medicines including artemisia anomala, harlequin glorybower leaves, hematoxylon, herba siegesbeckiae, dried lacquer, gentiana macrophylla, vaccaria segetalis, aristolochia mollissima, native copper, erycibe obtusifolia, Chinese trumpet creeper, radix clematidis, herba lycopi, angelica pubescens, dalbergia wood, loose knots, gadfly, turtle shells, leech, rhizoma drynariae, pangolin, fructus psoraleae, achyranthes bidentata, platycladi seed, trogopterus dung, amber, carthamus tinctorius, dragon bone, peach kernels, magnet, caulis spatholobi, hawksbill, leonurus, polygonum cuspidatum, oyster and antelope horns. Due to the effects of the combined medicines, a synergistic effect can be achieved, and thus hyperostosis can be effectively treated.
Composition comprising a film-forming polymer and anorganic phase, and which also contains an alkyl ether of a polysaccharide (I) formed from units comprising at least two different osidic rings, each unit having at least one hydroxyl group substituted by a saturated alkyl hydrocarbon chain, provided that the organic phase contains at least one medium which is a solvent for the (I). Preferably in (I), 2-4 OH groups per unit are substituted by a saturated alkyl hydrocarbon chain. The alkyl chain contains 1-24 (2-10) C and is especially selected from Me, Et, n-Pr, i-Pr, n-Bu, i-Bu and t-Bu. The osidic rings are preferably selected from mannose, galactose, glucose, furanose, rhamnose and arabinose. (I) are alkyl ethers of a gum such as guar gum, carob gum, karaya gum, tragacanth gum, or mixtures of these, particularly an alkylated galactomannan with 1-6 (1-3) C alkyl chains, and alkylated guar gum with an ethyl chain having a degree of substitution of 2-3. (I) has a molecular weight of greater than 200,000. The weight ratio of the amount of liquid fatty phase to thickener (I) is 5-500
The present invention relates to a health care oral liquid for old people and a preparation method thereof. Basic components of the health care oral liquid comprise scutellaria root, earthworm, epimedium, propolis, hippophae rhamnoides fruit, liquorice, etc. The present invention has the advantages of simple preparation, suppression of lipoxygenase, antioxidation, clearing of peroxylradicals in a human body, protection of vitamin C from being oxidated and damaged, anti-aging, reinforcement of immunity of a human body, suppression of allergic reaction, enhancement of metabolism of nucleic acid level, cancer resistance, mutation resistance, antivirus, inflammation, various disease source bioactivity resistance, such as microorganisms, etc. The present invention has the high medical care value in aspects of preventing and curing usual frequently encountered diseases of old people, etc. The present invention has significant functions for various common diseases, such as high blood pressure, cardiovascular diseases, diabetes, bronchitis, pneumonitis, gastric ulcer, liver harm, tumour, various kinds of pathogenic microorganism infection, etc. of old people.