anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine, chemical-pharmaceutical industry. SUBSTANCE: invention relates to the development of high-active tranquilizing agent. The proposed composition comprises phenazepam, lactose, potato starch, calcium stearate, gelatin or polyvinylpyrrolidone of mean molecular mass and talc. Invention proposes a method of preparing a pharmaceutical composition that involves preparing the triturating mixture of phenazepam with lactose and addition of potato starch to the prepared mixture; remained lactose is wetted with gelatin solution or polyvinylpyrrolidone of mean molecular mass, dried, passed repeatedly through granulator device; the obtained dry granulate is mixed with talc, calcium stearate and potato starch and tabletted. Method provides uniform mixing components and optimal bioavailability of an active substance. As compared with other preparation the proposed pharmaceutical composition shows the more high soporific, sedative and tranquilizing activities and corresponds to requirements of The State Pharmacopoeia XI. EFFECT: enhanced valuable medicinal properties, improved method of preparing. 2 cl
A strain capable of producing arginine deiminase and the use thereof are provided. A rapid method of screening the strain, which is capable of producing arginine deiminase, is also provided. A method of producing arginine deiminase by fermentation of Pseudomonas plecoglossicida CGMCC No.2039 which is capable of producing arginine deiminase. By cloning the gene of arginine deiminase from the chromosomal DNA of Pseudomonas plecoglossicida CGMCC No.2039, the gene sequence of arginine deiminase is obtained. By fermentation culturing for 20-24 hours under aerobic condition and pH6.5-8.0 circumstance, the activity of arginine deiminase can achieve1.6U/mL fermentation liquor. The arginine deiminase produced by Pseudomonas plecoglossicida CGMCC No.2039 shows strong inhibition effect on liver cancer cell strain.
PCT No. PCT/EP95/02050 Sec. 371 Date Dec. 2, 1996 Sec. 102(e) Date Dec. 2, 1996 PCT Filed May 30, 1995 PCT Pub. No. WO95/33769 PCT Pub. Date Dec. 14, 1995The invention relates to a process for the preparation of cardiodilatin fragments, to highly purified cardiodilatin fragments, and to appropriate intermediates for the preparation of said fragments. Furthermore, the invention relates to highly purified cardiodilatin fragments which are free of peptide impurities and exhibit a single migration peak in capillary electrophoresis, as well as to appropriate processes for the preparation of same.
Subject will self-apply the test sunscreen formula to his/her face with the goal of applying 0.65 to 0.85 grams. Subject should sweat profusely.
The human brain has constant access to a multitude of complex signals, which it must simplify and organize in order to sustain the integrity of the organism. Many of these signals originate from outside of the body, such as lights, sounds, and smells, and much is known about how humans consciously perceive these 'exteroceptive' signals and how the human brain represents them. Comparatively little is known about how the human brain processes 'interoceptive' signals originating from inside of the body, despite the fact that the brain has access to far more of them (for instance, intestinal tension, bladder distension, breath, heartbeat, body temperature, blood pressure, serum osmolality, inflammation, proprioception etc.).

The current study study therefore aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or brain injury. Participants in this study will receive stimulation of the cardiorespiratory channel of the interoceptive system using bolus intravenous infusions of isoproterenol, a peripherally acting medication similar to adrenaline, and saline. Stimulation will occur during functional magnetic resonance imaging (fMRI) as well as outside of the fMRI scanner. After the scan participants will consume a meal. By evaluating the same interoceptive sensations across different human illnesses, the investigators hope to provide convergent evidence resulting in identification of core underlying neural processes, and to discern relative contributions in each condition.
In making a mobile starch-base dusting powder, starch granules in water, e.g. at least 25 per cent. of water computed on the weight of starch, are intimately mixed and coated with a finely divided, freshly precipitated, water-insoluble inorganic salt or hydroxide whose particles are smaller than the starch granules and the coated starch is then dried and, if necessary, ground to a fine powder.  The starch may be dispersed in water with two water-soluble inorganic compounds which react to form a finely divided precipitate.  For example, aqueous solutions of the following compounds may be added to starch dispersions; aluminium sulphate and tri-sodium phosphate, aluminium sulphate and soda ash, Epsom salts and tri-sodium phosphate, cupric sulphate and sodium hydroxide, calcium chloride and soda ash, calcium chloride and magnesium sulphate, tri-sodium phosphate and calcium chloride, sodium silicate and hydrochloric acid, zinc sulphate and sodium hydroxide, barium chloride and sodium sulphate.  Starch may be coated with freshly precipitated magnesium hydroxide. Alternatively, aqueous solutions of aluminium sulphate and tri-sodium phosphate may be mixed and the resulting suspension of aluminium phosphate may then be mixed with an aqueous dispersion of starch.  Preferably, at least one part by weight of the water-insoluble salt or hydroxide is used to coat each 6800 parts of starch.ALSO:In making mobile starch-base dusting powders, which may be used as carriers for fungicides, insecticides and medicaments, starch granules in water, e.g. at least 25 per cent. of water computed on the weight of starch, are intimately mixed and coated with a finely divided, freshly precipitated water-insoluble inorganic salt or hydroxide whose particles are smaller than the starch granules and the coated starch is then dried and, if necessary, ground to a fine powder.  The starch may be dispersed in water with two water-soluble inorganic compounds which react to form a finely divided precipitate.  For example, aqueous solutions of the following compounds may be added to starch dispersions; aluminium sulphate and tri-sodium phosphate, aluminium sulphate and soda ash, Epsom salts and tri-sodium phosphate, cupric sulphate and sodium hydroxide which precipitate a fungicide, calcium chloride and soda ash, calcium chloride and magnesium sulphate, tri-sodium phosphate and calcium chloride, sodium silicate and hydrochloric acid, zinc sulphate and sodium hydroxide, barium chloride and sodium sulphate.  Starch may be coated with freshly precipitated magnesium hydroxide. Alternatively, aqueous solutions of aluminium sulphate and tri-sodium phosphate may be mixed and the resulting suspension of aluminium phosphate may then be mixed with an aqueous dispersion of starch.  Preferably, at least one part by weight of the water-insoluble salt or hydroxide is used to coat each 6,800 parts of starch.
Acute pancreatitis (AP) is the most common pancreatic disease of childhood with an increasing incidence estimated at 13.2 cases in 100,000 children per year. Given the dearth of pediatric literature, most pediatric providers often rely on diagnostic, prognostic and treatment guidelines that have been derived from adults. This is problematic because adult therapeutic guidelines fail to consider the unique age-related responses and requirements of childhood. Pain management is one of the cornerstones in the treatment of pancreatitis, with abdominal pain being the most common presenting symptom of AP. Currently, there are no data on optimal pain management in pediatric AP. Older guidelines suggest that the "use of intravenous patient-controlled analgesia (PCA) is advantageous" as it allows the patient to self-administer opioids and strike a balance between analgesia and side effects. This requires cognitive maturity to understand how to use PCA and poses challenges for younger children, particularly infants and toddlers, as well as pediatric patients with developmental delay. It is particularly concerning that greater than 94% of surveyed pediatric practitioners would use morphine or related opioids as a first-line therapy in children with AP especially when there have been no studies examining the benefits/risks of opioid vs non-opioid analgesics or opioid-sparing therapies in pediatric AP. Furthermore, we recently reported a retrospective analysis demonstrating that opioids are prescribed far more frequently either alone or in combination with non-opioids (70%) than non-opioid alternatives alone (30%). Amongst all types of analgesia prescribed to children who presented to the BCH emergency department (ED) with acute pancreatitis, morphine was the most common. Further research in this area is imperative, particularly given the recent opioid epidemic. From a pediatric perspective, it has been demonstrated that adolescents are amongst those at risk for opioid abuse, thus there is an urgent need to determine whether opioids are necessary for the management of pain in this vulnerable population with AP.
PROBLEM TO BE SOLVED: To obtain a sustained release oral medicine speed controllably released without depending on various kinds of physiological factors such as pH by coating acetaminophen with a specific polymer material. SOLUTION: This prescription is obtained by coating acetaminophen with a water-insoluble and water-permeable polymer material. Methacrylate-ester copolymer, especially a compound of the formula (R is an alkyl or an aminoalkyl; (n1 ) to (n2 ) are each selected so that the methacrylate ester copolymer has about 100,000 to about 1,000,000 molecular weight) is preferably used as the polymer material. In the formula, (n1 ):(n2 ) is preferably about 1:2 to about 2:1 and (n1 +n2 ) is preferably 1:>=15. Acetaminophen particles have preferably about 180 to about 425 micron average diameter. Furthermore, a mixture of uncoated acetaminophen particles with acetaminophen particles coated with the above water-insoluble polymer material can be used as the dosage form.
BACKGROUND: The trajectories of haemoglobin in patients with chronic kidney disease (CKD) have been poorly described. In such patients, we aimed to identify typical haemoglobin trajectory profiles and estimate their risks of major adverse cardiovascular events (MACE).
METHODS: We used 5-year longitudinal data from the CKD-REIN cohort patients with moderate to severe CKD enrolled from 40 nationally representative nephrology clinics in France. A joint latent class model was used to estimate, in different classes of haemoglobin trajectory, the competing risks of (i) MACE + defined as the first event among cardiovascular death, non-fatal myocardial infarction, stroke or hospitalization for acute heart failure, (ii) initiation of kidney replacement therapy (KRT) and (iii) non-cardiovascular death.
RESULTS: During the follow-up, we gathered 33 874 haemoglobin measurements from 3011 subjects (median, 10 per patient). We identified five distinct haemoglobin trajectory profiles. The predominant profile (n = 1885, 62.6%) showed an overall stable trajectory and low risks of events. The four other profiles had nonlinear declining trajectories: early strong decline (n = 257, 8.5%), late strong decline (n = 75, 2.5%), early moderate decline (n = 356, 11.8%) and late moderate decline (n = 438, 14.6%). The four profiles had different risks of MACE, while the risks of KRT and non-cardiovascular death consistently increased from the haemoglobin decline.
CONCLUSION: In this study, we observed that two-thirds of patients had a stable haemoglobin trajectory and low risks of adverse events. The other third had a nonlinear trajectory declining at different rates, with increased risks of events. Better attention should be paid to dynamic changes of haemoglobin in CKD.
Aneuploidy is highly detrimental to organisms due to genomic imbalance. However, the influence of parental unbalanced genome conditions on gene expression of their offspring remains unclear, particularly in animals. To further explore the molecular regulatory mechanisms, we firstly analyzed the expression patterns of aneuploid Drosophila offspring from different parents with unbalanced genomes via reciprocal crosses and studied the potential functions of male-specific lethal 2 (MSL2) in this process. The results showed that the ectopic expression of MSL2 in aneuploidy resulted in gene expression patterns closer to those of diploidy, including MSL2 target genes, maternal genes, mitochondrial genes, and transposable elements. In addition, it was also found that ERp60, the key target gene of MSL2, played a crucial role in regulating endoplasmic reticulum (ER) Ca2+ homeostasis through its interaction with the STIM1 protein. When it was overexpressed, ER Ca2+ levels and the survival of aneuploid females were significantly increased. Furthermore, we observed upregulated ER Ca2+ levels identified in aneuploid brains, which suggested that Ca2+ homeostasis may be involved in the regulation mediated by MSL2 in aneuploid genomes.
The aim of the study is:

i) Evaluation of the incidence and activity of CE (expressed as the number of plasma cells / 1 High Power Field, HPF) in women undergoing surgical treatment for pelvic endometriosis due to pain or infertility; ii) Evaluation of the correlation of CE activity (expressed as the number of plasma cells/ 1 HPF) with endometriosis staging according to the American Society for Reproductive Medicine Classification System iii) Evaluation of the impact of surgical removal of pelvic endometriosis foci on CE activity iv) Comparison of the percentage of women with persistent CE after surgery in the subgroup receiving empiric antibiotics (Amoxicillin + Clavulanic Acid 875 mg + 125 mg, twice daily orally for 7 days) and the subgroup without antibiotics. The study will include women aged 18-45 undergoing laparoscopic surgery for pelvic endometriosis. Additionally, an endometrial aspiration biopsy will be performed. Endometriosis will be confirmed by histopathology. The stage of endometriosis will be determined according to revised American Society for Reproductive Medicine Classification. CE will be confirmed by histopathology and immunohistochemical staining with monoclonal murine antibodies against human plasma cells CD138, and will be defined as the presence of plasma cells in the endometrial stroma, the value will be given as the number of plasma cells/1 High Power Field (HPF) and the cut-off will be calculated using the receiver operating characteristic (ROC) curve. A control endometrial biopsy to confirm the effectiveness of empiric antibiotic therapy will be performed up to 3 cycles after the primary procedure.
In the process of teaching personnel protective equipment (PPE) use with the scenario-based high-fidelity simulation mannikin, a simulation application was made with 26 students. The simulation scenario was implemented with 13 groups consisting of 3 students each playing different roles (nurse, head nurse, patient relative). Throughout the scenario, the students who played the role of the nurse and the head nurse simulated the PPE wearing-removal practice in a way to cover all steps of the process (preparation, implementation, and evaluation). During the implementation of the scenario, the student playing the role of the patient's relative provided guiding clues to the nurse when needed. Debriefing was started right after the simulation. Frequency of administration the implementation of each group is once and the debriefing stage where the learning process was reinforced and lasted 30 minutes.
INTRODUCTION: Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positive bacteria. Therapeutic drug monitoring of linezolid concentrations is recommended to maximise its efficacy and safety, mainly haematological toxicity. Different pharmacokinetic/pharmacodynamic targets have been proposed to improve linezolid exposure: the ratio of the area under the concentration-time curve during a 24-hour period to minimum inhibitory concentration (MIC) between 80 and 120; percentage of time that the drug concentration remains above the MIC during a dosing interval greater than 85% and the trough concentration between 2 and 7 mg/L. This clinical trial aims to evaluate the safety, efficacy and the clinical and economic utility of personalised dosing of linezolid using Bayesian forecasting methods to attain pharmacokinetic/pharmacodynamic targets, known as model-informed precision dosing.
METHODS AND ANALYSIS: This is a pragmatic, multicentre, randomised, parallel, controlled, phase IV and low intervention trial. Participants will be randomly assigned 1:1 to each group (n=346 per group). Control group will receive the standard dose of linezolid. Intervention group will receive personalised dosage of linezolid based on pharmacokinetic-pharmacodynamic adjustments. The primary outcome will be the incidence of thrombocytopenia in both groups.
ETHICS AND DISSEMINATION: This protocol was approved by the Ethical Committee of the Investigation with Medicines of Galicia (code 2022/140) and authorised by the Spanish Agency for Medicines and Medical Devices. The trial is implemented in accordance with the Declaration of Helsinki and the international ethical and scientific quality standard, the Good Clinical Practice. The results will be published in peer-reviewed journals.
TRIAL REGISTRATION NUMBER: EudraCT registration code: 2022-000144-30.
The retina is one of the highest metabolically active tissues with a high oxygen consumption, so insufficient blood supply leads to visual impairment. The incidence of related conditions is increasing; however, no effective treatment without side effects is available. Furthermore, the pathomechanism of these diseases is not fully understood. Our aim was to develop an optimal ischemic retinopathy mouse model to investigate the retinal damage in a time-dependent manner. Retinal ischemia was induced by bilateral common carotid artery occlusion (BCCAO) for 10, 13, 15 or 20 min, or by right permanent unilateral common carotid artery occlusion (UCCAO). Optical coherence tomography was used to follow the changes in retinal thickness 3, 7, 14, 21 and 28 days after surgery. The number of ganglion cells was evaluated in the central and peripheral regions on whole-mount retina preparations. Expression of glial fibrillary acidic protein (GFAP) was analyzed with immunohistochemistry and Western blot. Retinal degeneration and ganglion cell loss was observed in multiple groups. Our results suggest that the 20 min BCCAO is a good model to investigate the consequences of ischemia and reperfusion in the retina in a time-dependent manner, while the UCCAO causes more severe damage in a short time, so it can be used for testing new drugs.
Subjects 6 to \<12 years of age. Carisbamate, 60 mg, will be administered on Day 1 and 2 of the single dose period. Carisbamate will be administered at 30 mg twice daily (BID) during the multiple-dose period.
Electroconvulsive therapy (ECT) is considered the gold standard treatment for many psychiatric illnesses; however, it is not without risk. There have been no systematic reviews to date on new-onset atrial fibrillation following ECT. Thus, the aim of this study is to identify reported occurrences of new-onset atrial fibrillation following ECT and the ability to safely resume ECT thereafter.A case pertaining to the development of atrial fibrillation after ECT in a young healthy male is presented. In addition, a systematic review of the literature pertaining to atrial fibrillation after ECT was conducted through PubMed, PsycInfo, and EMBASE. Of the 233 articles screened, 15 articles were selected for in-depth review. Of the 15 articles, only 10 articles met inclusion criteria. These articles included 9 case reports and 1 retrospective review. The retrospective review included 1 patient that developed atrial fibrillation out of 13 patients receiving ECT at the site. The 10 patients included varied in age, risk factors, type of ECT conducted, and treatment of the atrial fibrillation. Of the 4 articles that discussed outcomes, all patients were able to return to ECT without further complications.There are many potential reasons ECT may induce atrial fibrillation, and there are additional treatment considerations for atrial fibrillation in patients receiving ECT. Notably, our results indicate that many have been able to continue ECT without further complications; however, more research is needed to identify the frequency of this adverse reaction.
The invention provides a bath lotion for pets. The bath lotion is used for preventing and treating pet eczema and contains Chinese traditional medicine extracts. The Chinese traditional medicine extracts contain radix sophorae flavescentis, golden cypress, honeysuckle, fructus kochiae, rhizoma atractylodis, golden larch bark, menthol and other constituents. After being extracted and refined, the bath lotion is used in cooperation with a common bath lotion and has the obvious effects of inhibiting bacteria, killing pests, clearing heat and nursing the pets. The bath lotion, containing the Chinese traditional medicine extracts, for the pets has the good effects of preventing and treating pet eczema, scytitis and pruritus. The bath lotion is good in clinical application effect, low in cost and free of residues and has broad market prospects.