anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Wixela Inhub® should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. Wixela Inhub® has not been studied in subjects with acutely deteriorating asthma or COPD. The initiation of Wixela Inhub® in this setting is not appropriate. 

Serious acute respiratory events, including fatalities, have been reported when salmeterol, a component of Wixela Inhub®, has been initiated in patients with significantly worsening or acutely deteriorating asthma. In most cases, these have occurred in patients with severe asthma (e.g., patients with a history of corticosteroid dependence, low pulmonary function, intubation, mechanical ventilation, frequent hospitalizations, previous life-threatening acute asthma exacerbations) and in some patients with acutely deteriorating asthma (e.g., patients with significantly increasing symptoms; increasing need for inhaled, short-acting beta2-agonists; decreasing response to usual medications; increasing need for systemic corticosteroids; recent emergency room visits; deteriorating lung function). However, these events have occurred in a few patients with less severe asthma as well. It was not possible from these reports to determine whether salmeterol contributed to these events.

Increasing use of inhaled, short-acting beta2-agonists is a marker of deteriorating asthma. In this situation, the patient requires immediate reevaluation with reassessment of the treatment regimen, giving special consideration to the possible need for replacing the current strength of Wixela Inhub® with a higher strength, adding additional ICS, or initiating systemic corticosteroids. Patients should not use more than 1 inhalation twice daily of Wixela Inhub®. 

Wixela Inhub® should not be used for the relief of acute symptoms, i.e., as rescue therapy for the treatment of acute episodes of bronchospasm. Wixela Inhub® has not been studied in the relief of acute symptoms and extra doses should not be used for that purpose. Acute symptoms should be treated with an inhaled, short-acting beta2-agonist.

When beginning treatment with Wixela Inhub®, patients who have been taking oral or inhaled, short-acting beta2-agonists on a regular basis (e.g., 4 times a day) should be instructed to discontinue the regular use of these drugs.
BACKGROUND: Surgical site infections are one of the major clinical problems in surgical departments that cost hundreds of millions of dollars to healthcare systems around the world.
AIM: The study aimed to address the pressing issue of surgical site infections, which pose significant clinical and financial burdens on healthcare systems globally. Recognizing the substantial costs incurred due to these infections, the research has focused on understanding the role of lipase and protease production by multi-drug resistant bacteria isolated from surgical wounds in the development of post-surgical wound infections.
METHODS: For these purposes, 153 pus specimens were collected from patients with severe post-surgical wound infections having prolonged hospital stays. The specimens were inoculated on appropriate culture media. Gram staining and biochemical tests were used for the identification of bacterial growth on suitable culture media after 24 hours of incubation. The isolated pathogens were then applied for lipase and protease, key enzymes that could contribute to wound development, on tributyrin and skimmed milk agar, respectively. Following the CSLI guidelines, the Kirby-Bauer disc diffusion method was used to assess antibiotic susceptibility patterns. The results revealed that a significant proportion of the samples (127 out of 153) showed bacterial growth of Gram-negative (n = 66) and Gram-positive (n = 61) bacteria. In total, isolated 37 subjects were declared MDR due to their resistance to three or more than three antimicrobial agents. The most prevalent bacteria were Staphylococcus aureus (29.13%), followed by S. epidermidis (18.89%), Klebsiella pneumoniae (18.89%), Escherichia coli (14.96%), Pseudomonas aeruginosa (10.23%), and Proteus mirabilis (7.87%). Moreover, a considerable number of these bacteria exhibited lipase and protease activity with 70 bacterial strains as lipase positive on tributyrin agar, whereas 74 bacteria showed protease activity on skimmed milk agar with P. aeruginosa as the highest lipase (69.23%) and protease (76.92%) producer, followed by S. aureus (lipase 62.16% and protease 70.27%).
RESULTS: The antimicrobial resistance was evaluated among enzyme producers and non-producers and it was found that the lipase and protease-producing bacteria revealed higher resistance to selected antibiotics than non-producers. Notably, fosfomycin and carbapenem were identified as effective antibiotics against the isolated bacterial strains. However, gram-positive bacteria displayed high resistance to lincomycin and clindamycin, while gram-negative bacteria were more resistant to cefuroxime and gentamicin.
CONCLUSION: In conclusion, the findings suggest that lipases and proteases produced by bacteria could contribute to drug resistance and act as virulence factors in the development of surgical site infections. Understanding the role of these enzymes may inform strategies for preventing and managing post-surgical wound infections more effectively.
Participants in this group will complete questionnaires at baseline (birth) and after 1-2-3 years. At baseline samples will be collected (blood/nasopharyngeal/urine/feces/buccal). During the RSV season(Oct-May) active sampling for RSV will be done when infants experience a respiratory infection.
On Day 1 and Day 8 of each 3-week cycle, patients will receive gemcitabine and cisplatin. Patients may continue gemcitabine and cisplatin for up to 2 years in absence of disease progression or unacceptable toxicity.
Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as MAOIs, selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [see Drug Interactions (7.1)]. Amphetamines and amphetamine derivatives are known to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) and display minor inhibition of CYP2D6 metabolism [see Clinical Pharmacology (12.3)]. The potential for a pharmacokinetic interaction exists with the coadministration of CYP2D6 inhibitors which may increase the risk with increased exposure to ADDERALL XR. In these situations, consider an alternative nonserotonergic drug or an alternative drug that does not inhibit CYP2D6 [see Drug Interactions (7.1)]. Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).

Concomitant use of ADDERALL XR with MAOI drugs is contraindicated [see Contraindications (4)].

Discontinue treatment with ADDERALL XR and any concomitant serotonergic agents immediately if symptoms of serotonin syndrome occur, and initiate supportive symptomatic treatment. Concomitant use of ADDERALL XR with other serotonergic drugs or CYP2D6 inhibitors should be used only if the potential benefit justifies the potential risk. If clinically warranted, consider initiating ADDERALL XR with lower doses, monitoring patients for the emergence of serotonin syndrome during drug initiation or titration, and informing patients of the increased risk for serotonin syndrome.
6-Glucose-iodhydrin is prepared by saponifying tetra - acetyl - 6 - glucose - iodhydrin.  Sodium 3.5-dibrom - 4 - acetamino - 1 - benzoate is prepared by boiling p-amino-benzoic acid and the calculated quantity of bromine, both in glacial acetic acid for two hours, with stirring, to produce 3-5-dibrom-4-amino-1-benzoic acid, boiling with acetic anhydride to produce the acetyl compound, and adding the calculated quantity of sodium ethylate in alcoholic solution.ALSO:In the production of X-ray photographs of the urogenital system of an organism an X-ray contrast medium is employed comprising an aqueous solution of an easily soluble organic bromine or iodine compound substantially indifferent to the organism.  The medium is administered internally, preferably by intravenous injection, the quantities employed for the human organism comprising 10-100 cc., preferably 60 cc., of water containing at least 2, and preferably 18-20 gms., of iodine in combined form; larger proportions of bromine must be employed.  Suitable compounds are sodium 2-oxo-5-iodo-pyridine-N-acetate; di-iodo-chelidamic acid sodium and ammonium salts; aliphatic halogen carboxylic acids such as b -iodo-propionic acid; halogen alkyl sulphonic acids; halogen alkyl sulphuric acids; halogen substituted polyhydroxy compounds such as 6-glucose-iodhydrin, prepared by saponifying tetra-acetyl-6-glucose-iodhydrin; sodium 3,5-dibrom-4-acetamino-1-benzoate, prepared by boiling p-amino-benzoic acid and the calculated quantity of bromine, both in glacial acetic acid for two hours, with stirring, to produce 3-5-dibrom-4-amino-1-benzoic acid, boiling with acetic anhydride to produce the acetyl compound, and adding the calculated quantity of sodium ethylate in alcoholic solution.  The Specification as open to inspection under Sect. 91 (3) (a) refers to the use of organic halogen compounds in general.  This subject-matter appears in the Specification as accepted only in the restricted form set out above.
The invention discloses a traditional Chinese medicine extract with the bacteriostasis, scrap removing and itch relieving function and a preparation method and application thereof. The traditional Chinese medicine extract is prepared from, by weight, 40-60 parts of walnuts, 150-250 parts of almond, 150-250 parts of Chinese wax gourd seeds and 30-60 parts of radix asparagi. The raw materials are extracted through water, extracted liquid precipitates through ethanol or an ethanol solution, filtration is performed, and obtained filter liquor is the traditional Chinese medicine extract with the bacteriostasis, scrap removing and itch relieving function. The traditional Chinese medicine extract can be used for cleaning hair deeply and has the nourishing, bacteriostasis, scrap removing and itch relieving effect, and the cleaned hair is natural in gloss, soft, smooth and easy to tease. When the traditional Chinese medicine extract is used for a long time, the hair can be natural, healthy, supple, dull black and bright. The traditional Chinese medicine extract is mild in property, prepared from common nontoxic traditional Chinese medicine, and suitable for people with any hair quality and can be used for preparing liquid shampoo, cream shampoo, hair conditioners and other daily use chemicals.
Embodiments for managing medical anomalies by one or more processors are described. Medical data associated with an individual is received. The medical data is detected by a first computing device. The first computing device includes a mobile electronic device. The received medical data is compared to stored medical data associated with the individual. Based on the comparison of the received data to the stored data, a control signal for a second computing device is caused to be generated.
Chronic inflammation is a key element in the progression of essential hypertension (EH). Calcium plays a key role in inflammation, so its receptor, the calcium-sensing receptor (CaSR), is an essential mediator of the inflammatory process. Compelling evidence suggests that CaSR mediates inflammation in tissues and immune cells, where it mediates their activity and chemotaxis. Macrophages (Mφs) play a major role in the inflammatory response process. This study provided convincing evidence that R568, a positive regulator of CaSR, was effective in lowering blood pressure in spontaneously hypertensive rats (SHRs), improving cardiac function by alleviating cardiac hypertrophy and fibrosis. R568 can increase the content of CaSR and M2 macrophages (M2Mφs, exert an anti-inflammatory effect) in myocardial tissue, reduce M1 macrophages (M1Mφs), which have a pro-inflammatory effect in this process. In contrast, NPS2143, a negative state regulator of CaSR, exerted the opposite effect in all of the above experiments. Following this study, R568 increased CaSR content in SHR myocardial tissue, lowered blood pressure, promoted macrophages to M2Mφs and improved myocardial fibrosis, but interestingly, both M1Mφs and M2Mφs were increased in the peritoneal cavity of SHRs, the number of M2Mφs remained lower than M1Mφs. In vitro, R568 increased CaSR content in RAW264.7 cells (a macrophage cell line), regulating intracellular Ca2+ ([Ca2+]i) inhibited NOD-like receptor family protein 3 (NLRP3) inflammasome activation and ultimately prevented its conversion to M1Mφs. The results showed that a decrease in CaSR in hypertensive rats causes further development of hypertension and cardiac damage. EH myocardial remodeling can be improved by CaSR overexpression by suppressing NLRP3 inflammasome activation and macrophage polarization toward M1Mφs and increasing M2Mφs.
INTRODUCTION: Fatigue is prevalent in people with inflammatory bowel disease (IBD) and has been associated with IBD activity, sleep quality, depression, and anxiety. This study aimed to identify fatigue profiles or clusters through latent profile analysis.
METHODS: An online questionnaire was administered through three tertiary IBD centres, social media and through Crohn's Colitis Australia. Fatigue was assessed via the Functional assessment of chronic illness measurement system fatigue subscale (FACIT-F), a validated assessment of fatigue and its severity. Validated measures of anxiety, depression, IBD activity and sleep quality were also included. Latent profile analysis was performed including fatigue, sleep quality, active IBD, and depression and anxiety. The relationships between profiles and IBD and demographic data were investigated.
RESULTS: In a cohort of 535 respondents, 77% were female, the median age was 41 years (range 32-52 years), and the majority had Crohn's disease (62%). Severe fatigue was seen in 62%. Latent profile analysis identified four distinct profiles differing by fatigue score - low fatigue, at-risk profile, active IBD, and a poor mental health profile. Female gender, obesity and opioid usage were associated with higher risk of being in the active IBD and poor mental health profile. Age over 40 was associated with lower risk of being in the poor mental health profile.
CONCLUSION: Latent profile analysis identifies four classes of fatigue in an IBD cohort with associations with specific risk factors for fatigue along with specific IBD and demographic attributes. This has implications for the classification of fatigue in IBD and treatment algorithms.
BACKGROUND: Pomegranate (Punica granatum L.) is a tropical fruit crop of pharma-nutritional importance. However, it faces farming challenges due to pests and diseases, particularly bacterial blight and wilt. Developing resistant cultivars is crucial for sustainable pomegranate cultivation, and understanding resistance's genetic basis is essential.
METHODS AND RESULTS: We used an extensive resistance gene analogues (RGA) prediction tool to identify 958 RGAs, classified into Nucleotide Binding Site-leucine-rich repeat (NBS-LRR) proteins, receptor-like kinases (RLKs), receptor-like proteins (RLPs), Transmembrane coiled-coil (TM-CC), and nine non-canonical RGAs. RGAs were distributed across all eight chromosomes, with chromosome 02 containing the most RGAs (161), and chromosome 08 having the highest density (4.42 RGA/Mb). NBS-LRR genes were predominantly present on chromosomes 08 and 02, whereas RLKs and RLPs were primarily located on chromosomes 04 and 07. Gene ontology analysis revealed that 475 RGAs were associated with defence against various biotic stresses. Using RNAseq, we identified 120 differentially expressed RGAs, with RLKs (74) being prominent among the differentially expressed genes.
CONCLUSION: The discovery of these RGAs is a significant step towards breeding pomegranates for pest and disease resistance. The differentially expressed RLKs hold promise for developing resistant cultivars against bacterial blight, thereby contributing to the sustainability of pomegranate cultivation.
Identical placebo capsule twice daily for 5 days (10 doses). Participants one year of age and older up to a maximum of 88 pounds will receive a placebo syrup. The dose will be based on weight as follows: \<=33 pounds,2 mL doses, two times per day; 34 - 51 pounds, 3 mL doses, two times per day; 52-88 pounds, 4 mL doses, two times per day.
<P>PROBLEM TO BE SOLVED: To provide a bath agent composition which does not undergo scent deterioration during storage and is excellent in storage stability.  <P>SOLUTION: The bath agent composition contains particles prepared by granulating a perfume with a water-soluble polymer being solid or paste at normal temperature. The water-soluble polymer is preferably polyethylene glycol. The weight ratio of the water soluble polymer to the perfume in the particle is 1:1 to 10:1. The particle diameter of the granulated particle is 10 to 2,000 μm. The bath agent composition contains the granulated particles in an amount of 0.1 to 20 wt.%.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Presented herein are systems and methods for magnetic resonance fingerprinting with increased volumetric coverage using deep learning reconstruction. Fingerprinting techniques enable obtaining quantitative molecular information using a scanner in a non-invasive way. However, existing techniques for slice acquisition result in limited spatial coverage. In a single size approach, the pulse sequence can include a full saturation train. The pulse saturation train can excite a single slice. After a delay to allow the magnetization to recover, the pulse saturation train excites the magnetization again with another saturation pulse with different saturation powers. The magnetization is repeated that over a certain length of acquisitions. The magnetization can generate the fingerprint from which to extract the underlying quantitative parameters. Instead of exciting a single slice and allowing it to recover, the present disclosure can excite multiple slices to increase the spatial coverage without increasing the scan time.
A 36-year-old male with no significant medical history presented to the ED with progressive left-sided neck and facial pain for the last 7 days. The patient also reported subjective fevers, chills, difficulty opening his mouth, and anorexia for the last 1 week. He denied cough, chest pain or tightness, shortness of breath, skin rashes, dysphagia, or odynophagia. He reported use of two to three 59.15 mL beers daily for the last 20 years. There was no recent travel or sick contact exposure. He did not report any TB exposure, IV drug use, or recent sexual encounters.
Primary progressive aphasia (PPA) is an umbrella term that encompasses a group of neurodegenerative syndromes characterized by varying combinations of progressive speech and language problems. Three clinical variants of PPA have been described and are well recognized: the agrammatic variant characterized by grammatical errors in speech and writing and typically associated with phonetic errors in speech; the semantic variant characterized by poor naming from loss of knowledge about the meaning of words; and the logopenic variant characterized by word retrieval problems and poor sentence repetition from impairment of working memory and phonemic errors. Pathological studies of PPA patients that died with postmortem examination of their brains have demonstrated that PPA is associated with a number of different abnormal cellular proteins that do not have perfect associations with the three PPA variants. One such protein is the microtubule associated protein, tau, which is the most common abnormal protein found in the brains of patients with PPA. Tau is an important protein that has been linked to the neurodegenerative process in many diseases. No neuroimaging studies have investigated tau deposition in PPA and hence the binding characteristics of AV-1451 (the Tau binding drug used in this study) in PPA are unknown. Understanding the binding characteristics of AV-1451 is crucial to help determine whether it can serve as a biomarker for tau deposition in the brains of patients with PPA.

FTD or Frontotemporal Dementias, including bvFTD, will also be included in this study.
PURPOSE: To obtain a skin cosmetic containing coffee bean extract, capable of preventing chapped skin, stain and ephelis and preventing skin aging prevention due to lipid peroxidation. CONSTITUTION: This skin cosmetic contains coffee bean extract in an amount of 0.001-20wt.%, preferably 0.01-10wt.% as dried weight of the extract based on total amount of cosmetic as an active ingredient. The coffee bean is obtained by using raw beans, dried beans or roasted beans of coffee and grinding the material, immersing the material in an aqueous solvent such as lower-alcohol (e.g. ethanol) or acetone or its water solution. The cosmetic can be prepared in cream, milky lotion, oil, lotion, pack, oitment, etc. The cosmetic has high safety and is usable also as an aqueous ultraviolet light absorber and has action exceeding that of vitamin E even in free radical erasing action and lipid peroxidation-suppressing action.
Fetal hypoxia and maternal stress frequently culminate in neuropsychiatric afflictions in life. To replicate this condition, we employed a model of prenatal severe hypoxia (PSH) during days 14-16 of rat gestation. Subsequently, both control and PSH rats at 3 months old were subjected to episodes of inescapable stress to induce learned helplessness (LH). The results of the open field test revealed an inclination towards depressive-like behavior in PSH rats. Following LH episodes, control (but not PSH) rats displayed significant anxiety. LH induced an increase in glucocorticoid receptor (GR) levels in extrahypothalamic brain structures, with enhanced nuclear translocation in the hippocampus (HPC) observed both in control and PSH rats. However, only control rats showed an increase in GR nuclear translocation in the amygdala (AMG). The decreased GR levels in the HPC of PSH rats correlated with elevated levels of hypothalamic corticotropin-releasing hormone (CRH) compared with the controls. However, LH resulted in a reduction of the CRH levels in PSH rats, aligning them with those of control rats, without affecting the latter. This study presents evidence that PSH leads to depressive-like behavior in rats, associated with alterations in the glucocorticoid system. Notably, these impairments also contribute to increased resistance to severe stressors.
Follow-up and management of heart failure medications provided by specialists at participating institutions. Doses of oral heart failure medications optimized within 2 weeks, provided clinical assessments and laboratory measures indicate that it is safe to increase doses.