anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Rivastigmine Transdermal System is available as 4.6 mg/24 hours, 9.5 mg/24 hours or 13.3 mg/24 hours of rivastigmine. 

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    Each transdermal system of 5 cm2 contains 9 mg rivastigmine, USP base with in vivo release rate of 4.6 mg/24 hours. The round transdermal system consists of a peach-colored backing randomly printed with “Rivastigmine 4.6 mg/24 hours” in brown ink, a translucent adhesive layer, and a clear to slightly hazy oversized release liner that is slit and has small dimples surrounding the transdermal system. Each transdermal system also has a clear to slightly hazy oversized underlay and is contained in a square pouch. The pouch is imprinted with lot number and expiration date.
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    Each transdermal system of 10 cm2 contains 18 mg rivastigmine, USP base with in vivo release rate of 9.5 mg/24 hours. The round transdermal system consists of a peach-colored backing randomly printed with “Rivastigmine 9.5 mg/24 hours” in brown ink, a translucent adhesive layer, and a clear to slightly hazy oversized release liner that is slit and has small dimples surrounding the transdermal system. Each transdermal system also has a clear to slightly hazy oversized underlay and is contained in a square pouch. The pouch is imprinted with lot number and expiration date.
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    Each transdermal system of 15 cm2 contains 27 mg rivastigmine, USP base with in vivo release rate of 13.3 mg/24 hours. The round transdermal system consists of a peach-colored backing randomly printed with “Rivastigmine 13.3 mg/24 hours” in brown ink, a translucent adhesive layer, and a clear to slightly hazy oversized release liner that is slit and has small dimples surrounding the transdermal system. Each transdermal system also has a clear to slightly hazy oversized underlay and is contained in a square pouch. The pouch is imprinted with lot number and expiration date.
Intrauterine Devices (IUDs) are an excellent method of contraception but are underutilized in the U.S. IUD use is expanding in the U.S. and is now routinely recommended for nulliparous women. The cervix of a nulliparous woman has a smaller diameter and can lead to more difficult and uncomfortable IUD insertions. Because of misoprostol's known ability to cause cervical dilation, some family planning providers use this drug to facilitate insertion. While there is a wealth of data on the use of misoprostol prior to many procedures requiring cervical dilation there is minimal objective evidence assessing its effect on provider ease of insertion or patient comfort during IUD insertion in nulliparas. The goal of this project is to evaluate whether misoprostol relative to placebo prior to IUD insertion in nulliparous women eases insertion and decreases pain. The results of this trial will be contributed to a prospective meta-analysis on the subject.
Invention applies to the medicine and pharmaceutical industry. The invention aims to increase the efficiency of treatment. The mixture consists of the following components in g: wild marjoram grass (Herba Origani) - 25, thyme grass (Herba Serpylli) - 25, pansy grass (Herba Violae) - 20, coltsfoot leaves (Folia Farfarae) - 15, marigold flowers (Flores Calendulae) - 15. The mixtures components are separately pulverised by a hammer crusher and the fine particles sifted. Components are mixed in a drum mixer until the mixture becomes homogeneous. For treatment the herb mixture infusion is used. For patients consuming the infusion, chemical medicines are not prescribed.
Alcohol misuse and smoking constitute two of the three leading preventable causes of death in the United States. Reluctance to treat tobacco dependence among those with AUD is misguided as recent research suggests smoking cessation treatment can be effective, does not increase risk of relapse to alcohol, and may even improve rates of sobriety. There is strong evidence for the short-term efficacy for alcohol misuse and smoking of contingency management (CM). It is an intensive behavioral therapy that provides incentives (vouchers, money) to individuals misusing substances contingent upon objective evidence from drug use. Implementation of CM has been limited because of the need to verify abstinence multiple times daily using clinic based monitoring. The investigators recently developed a smart-phone application which allows a patient to video themselves several times daily while using a small CO monitor and to transmit the data to a secure server which has made the use of CM for outpatient smoking cessation portable and feasible. This mobile CM (mCM) approach paired with cognitive-behavioral counseling and pharmacological smoking cessation aids has been effective in reducing smoking.

Thus, the purpose of this project is to develop a combined alcohol and smoking mCM intervention. The intervention will be developed in two successive cohorts of five participants, who will provide information on treatment acceptability and feasibility. A third cohort of participants (n=45) will participate in a randomized clinical trials to further examine feasibility and efficacy. The long term goal is to develop mCM procedures that will be used as part of a multi-component intervention to concurrently and effectively treat both alcohol misuse and smoking. As part of this project, the investigators will develop a multi-component telehealth alcohol and smoking mCM intervention. It will include mCM, cognitive-behavioral phone counseling, and standard smoking cessation pharmacotherapy. The work proposed in these aims will provide the first step toward implementation of an innovative approach that builds upon the power of mHealth technology to reduce the prevalence of both alcohol misuse and smoking.
Pediatric acute liver failure (PALF) is a severe liver dysfunction with complex pathological mechanisms and rapid development. MiRNAs have been identified as promising biomarkers for human disease screening and monitoring. This study focused on evaluating the clinical significance of miR-224-5p in PALF and revealing its potential molecular mechanism in regulating liver cell injury. This study enrolled 103 children with PALF and 55 healthy children without liver diseases. Serum miR-224-5p levels were compared between the two groups, and their clinical significance was estimated by analyzing the correlation with clinicopathological features and outcomes of PALF children. In vitro, a normal liver cell was treated with lipopolysaccharide (LPS), and cell growth and inflammation were assessed by CCK8 and ELISA assay. Upregulated miR-224-5p in PALF showed significance in screening PALF children from healthy children with the sensitivity and specificity of 78.64% and 84.47%, respectively. Increasing serum miR-224-5p in PALF children was closely associated with increasing prothrombin time, alanine transaminase, international normalized ratio, total bilirubin, ammonia, and aspartic transaminase and decreasing albumin of PALF children. MiR-224-5p was also identified as a risk factor for adverse outcomes in children with PALF. In LPS-treated liver cells, miR-224-5p could negatively regulate ZBTB20, and silencing miR-224-5p could alleviate the inhibited cell growth and promoted inflammation by LPS, which was reversed by ZBTB20 knockdown. Increasing miR-224-5p distinguished PALF children, predict severe disease development and risk of adverse prognosis. miR-224-5p also reguled LPS-induced liver cell injury via negatively regulating ZBTB20.
The invention relates to the field of biological medicines, in particular to application of Rheb1 as a key regulator of islet beta cell dysfunction. The experimental results show that Rheb1 is highly expressed in human and mouse islets. Beta cell specific Rheb1 knockdown resulted in spontaneous diabetes in mice, a reduction in beta cell size and mass, and impaired glucose-stimulated insulin secretion in human and mouse islets. In contrast, upregulation of Rheb1 increased beta cell proliferation and decreased apoptosis, resulting in increased beta cell size and mass. Mechanistically, Rheb1 promoted islet beta cell proliferation in humans and mice by activating the mTORC1/cyclin D1/2 pathway. Rheb1 also promoted GSIS of human and mouse pancreatic islets by activating the mTORC1/GLUT2 pathway. The invention discloses a key role of Rheb1 in regulating beta cell mass of beta cells and GSIS, and discloses a novel target point for treating diabetes.
The most frequently loco-regional analgesic techniques in scoliosis surgery are intrathecal, epidural, caudal morphine, or local infiltrations techniques including ultrasound guided thoracolumbar interfascial plane block. however these techniques possess some limitations in scoliosis surgery. Local anesthetic infiltration was first applied over 35 years ago in lumbar spine surgery as a reliable technique for pain relief. However meta-analysis of data reviled inconclusive and heterogeneous efficacy results.This conflict arise from the differences in the technique and drugs.There are three levels of infiltration; subcutaneous, muscular and perineural. Its timing either pre-incision or post-surgery. Generally the preemptive and deep infiltration offer better analgesia when compared with post-surgical and superficial forms. Different drugs including local anesthetics, epinephrine and adjuvants can be given as a single injection or infusion. Doses and volumes are also different, usually ranging from 10 to 30 ml at a concentration of 0.25% Bupivacaine. the use of epinephrine helps bleeding control Concomitantly, unlike the other techniques, bupivacaine infiltration was combined at three levels in this study; subcutaneous, muscular and neural paravertebral to provide sensory, motor and sympathetic blockade all together. In addition, this drug combination may help to maintain spinal cord perfusion by avoiding deliberate hypotension. The high volume sufficient for proper tissue infiltration combined at three anatomically guided levels for three types of nerves has not been described so far. This research may benefit all spine surgery patients.
Propionate metabolism is important in the development of diabetes, and fibrosis plays an important role in diabetic nephropathy (DN). However, there are no studies on biomarkers related to fibrosis and propionate metabolism in DN. Hence, the current research is aimed at evaluating biomarkers associated with fibrosis and propionate metabolism and to explore their effect on DN progression. The GSE96804 (DN : control = 41 : 20) and GSE104948 (DN : control = 7 : 18) DN-related datasets and 924 propionate metabolism-related genes (PMRGs) and 656 fibrosis-related genes (FRGs) were acquired from the public database. First, DN differentially expressed genes (DN-DEGs) between the DN and control samples were sifted out via differential expression analysis. The PMRG scores of the DN samples were calculated based on PMRGs. The samples were divided into the high and low PMRG score groups according to the median scores. The PM-DEGs between the two groups were screened out. Second, the intersection of DN-DEGs, PM-DEGs, and FRGs was taken to yield intersected genes. Random forest (RF) and recursive feature elimination (RFE) analyses of the intersected genes were performed to sift out biomarkers. Then, single gene set enrichment analysis was conducted. Finally, immunoinfiltrative analysis was performed, and the transcription factor (TF)-microRNA (miRNA)-mRNA regulatory network and the drug-gene interaction network were constructed. There were 2633 DN-DEGs between the DN and control samples and 515 PM-DEGs between the high and low PMRG score groups. In total, 10 intersected genes were gained after taking the intersection of DN-DEGs, PM-DEGs, and FRGs. Seven biomarkers, namely, SLC37A4, ACOX2, GPD1, angiotensin-converting enzyme 2 (ACE2), SLC9A3, AGT, and PLG, were acquired via RF and RFE analyses, and they were found to be involved in various mechanisms such as glomerulus development, fatty acid metabolism, and peroxisome. The seven biomarkers were positively correlated with neutrophils. Moreover, 8 TFs, 60 miRNAs, and 7 mRNAs formed the TF-miRNA-mRNA regulatory network, including USF1-hsa-mir-1296-5p-AGT and HIF1A-hsa-mir-449a-5p-ACE2. The drug-gene network contained UROKINASE-PLG, ATENOLOL-AGT, and other interaction relationship pairs. Via bioinformatic analyses, the risk of fibrosis and propionate metabolism-related biomarkers in DN were explored, thereby providing novel ideas for research related to DN diagnosis and treatment.
This invention relates to a novel gene that shows tissue specific expression and increased expression in a low calcium concentration medium. Low renin hypertension is characterized by decreased levels of serum ionized calcium in the presence of increased levels of parathyroid hormone. It is hypothesized that hypertensive factor(s) are co-secreted with PTH in SHR, a model of low renin hypertension, the parathyroid hypertensive factor being one of them. This invention identifies the genes differentially expressed in humans and in rat models of low renin hypertension (SHR) and in normotensive rat models (WKY) that are induced by low calcium levels in the parathyroid gland. A cDNA of a human gene and a cDNA of a rat gene expressed in parathyroid cells have been cloned and sequenced with no high score homology found in the gene banks. Their expression is higher in hypertensive models and their expression is enhanced by cell incubation in a low calcium concentration medium. In situ hybridization showed specific expression of the genes in adrenal medula and cortex, proximal tubules and parathyroid gland with very low levels in heart ventricles, kidney medulla and glomeruli and liver. These novel calcium regulated genes show tissue specific expression and increased expression in hypertension.
Patients undergo a standard stretching program 3 days weekly for 16 weeks. After 16 weeks, patients may undergo supervised exercise sessions comprised of CARE as in Arm I.
The present invention is directed to an immune complex composition, and a method of using that complex to enhance an in viva immune response against a preselected target antigen. The immune complexes of the present invention comprise a monoclonal antibody specific for binding to complement receptor (CR2) site on B lymphocytes linked to a target antigen. As shown in FIG. SA-SD immune complexes bound to monkey B cells are removed in concert with loss of CR2. FIGS. SA and SB demonstrate the % A1488 HB135 and % APhCy CD21 positive cells, out of the doubly positive FE CD20/PerCF CD45 population over time, after injection of A1488 labeled HB135 (an anti-CR2 antibody, administration indicated by first arrow) followed by injection of rabbit anti-mouse IgG (administration indicated by the second arrow). FIGS. SC and SD are plots of the molecules of equivalent soluble fluorochome (MESF) values for these populations.
298,915. Spa-Monopole Compagnie FermiÞre des Eaux et des Bains de Spa. Oct. 15, 1927, [Convention date]. Radio-active substances and preparations thereof.-In a process for the continuous activation of water or other liquids by treatment with radium emanation, the emanation is conveyed by a current of gas circulating in a closed system, the rate of circulation being independent of the flow of liquid under treatment. In the illustrated apparatus a current of air is caused to bubble through the flask a containing a solution of a radium salt and to pass through the pipes b to the column d down which water to be activated flows over helical baffles e. The air returns to the flask a through the pipes c. Circulation of the air is effected by the rise and fall of a body of mercury i effected by a pump j intermittently operated by means of a clockwork-driven contactbreaker l, reversal of the current being prevented by the mercury seals b<2>, c<2>. A potash bulb o in the pipe c absorbs carbon dioxide, and any explosive gas mixture which may be formed is destroyed by the heated tube n containing copper oxide of platinized asbestos.
Trough blood samples taken and analysed at baseline, 6m and 12m. Results fed back to recruiting clinical team who can choose to use these to influence their tapering decisions.
OBJECTIVES: To evaluate the perioperative morbidity and mortality associated with direct oral anticoagulants (DOACs) and warfarin for patients receiving transurethral resection of prostate (TURP).
PATIENTS AND METHODS: This was a single-centre, retrospective cohort analysis of patients who underwent TURP for benign prostate hyperplasia from April 2019 to December 2023. The primary objective was to evaluate the perioperative bleeding and thromboembolic risk between anticoagulated (AC) vs no-AC patients. The secondary objective was to evaluate perioperative bleeding and thromboembolic risk between different formulations of DOACs. Patient demographics, prior treatment, prostate size, baseline bleeding risk, and operative details were collected. Bleeding and thromboembolic-related morbidity were captured within a 3-month postoperative period. Perioperative management of AC therapy was recorded, and all patients had their AC therapy withheld. Cohort characteristic between the AC vs no-AC, and DOAC groups were analysed with two-sided t-test, and chi-square test. Further logistic regression analyses were carried out to identified significant variables between the groups. These significant variables were used for adjustment in inverse probability-weighted treatment effect analysis to evaluate bleeding risk.
RESULTS: There were 629 patients in the cohort, and 113 (18%) patients were receiving AC therapy. The AC patients were at 1.6 times statistically significant increased risk of acute bleeding, and 11 times increased risk of prolonged haematuria for >14 days. When compared to apixaban, patients on rivaroxaban conferred a statistically significant increased risk of acute bleeding by 2.21 times. Patients receiving AC therapy had a statistically significant increased risk of stroke in the perioperative setting (no-AC vs AC: 0.4% vs 2.7%, P = 0.01).
CONCLUSION: This is the first study to evaluate risk of bleeding for TURP patients receiving DOACs. The AC patients are more likely to experience haematuria and stroke in the perioperative period despite withholding therapy. Apixaban appears to cause less bleeding-related complications than rivaroxaban.
A direct connectivity system provides automated healthcare administrative transaction submission, including claim submission, eligibility verification and claim status, from healthcare service providers directly to payers. The direct connectivity system bypasses transaction processing intermediaries such as clearinghouses by directly connecting providers to payers in a many to many manner. Existing single payer web portals are supplanted by a many to many network that has a common interface across multiple payers. The direct connectivity system may receive responses directly from payers and may prepare or process the responses for a practice management program so that the service provider receives rapid feedback on the administrative transaction submission. The direct connectivity system may automatically analyze transaction file attributes to determine one or more of many payers to which to send a transaction file, from one of many providers. Batch and singleton file transfer is supported for multiple file formats, optionally with secure file transfer.
Football is a sport branch that requires a high degree of coordination, using motoric properties such as general endurance and coordination, as well as aerobic and anaerobic efforts. Studies argue that core strength positively affects athletic performance, reduces the risk of injury, and has an effect on the treatment of pain in the back area. Core stability is very important in terms of sports performance. Respiratory functions of all athletes, regardless of sports branches; It varies depending on physiological, functional, and psychological factors. Because disruption of respiratory muscle functions or respiratory muscle fatigue is a factor that jeopardizes the exercise performance of athletes. Numerous studies have shown that respiratory muscle training reduces respiratory muscle fatigue and sympatho-excitation during intense exercise. Previous studies focusing on the effects of respiratory muscle training have shown increased respiratory muscle strength in triathletes and marathon runners, rowers, cyclists, and divers. There are a limited number of studies investigating the effect of respiratory muscle training on football players. Our study, based on research in recent literature, aims to investigate the effects of core stabilization exercise, which includes functional respiratory muscle training, on respiratory function, aerobic capacity, trunk stabilization, and physical performance in football players.

Licensed athletes who actively engage in sports and play football will be included in the project. Volunteers included in the study will be randomly divided into two groups: study and control groups. Different methods will be used in the study for respiratory function test (PFT), measurement of respiratory muscle strength, trunk stabilization evaluation, and performance evaluation. To apply these methods, a spirometer device (according to ATS/ERS criteria with Cosmed Pony FX, Italy), portable, electronic oral pressure measurement device (with Micro Medical Micro RPM, Rochester, England), Plank and Sorenson tests will be used. A core stabilization exercise protocol including functional respiratory muscle training will be applied to the study group. The control group will only apply the same core stabilization exercise protocol as the study group.

This study aims to investigate the effects of functional respiratory muscle training and to add it to the training program of athletes according to the results. Aiming to improve the health and working dynamics of the respiratory muscles in athletes by applying functional muscle training to participants, as well as showing its effect on instant and prospective performance in athletes, is the ultimate goal to be shaped by the study findings. The study will shed light on this aspect with its functioning and method for researchers in the field. With the analysis and presentation of the data obtained from our study, the gaps in the current literature will be filled.
Mandala activity is painting with different pictures or shapes by creating a harmony of figures in different or the same colors. The entire intervention group was given a booklet consisting of 10 simple mandala drawings prepared by the researchers. Mandala activity: During the hospital stay on the zeroth, first and second postoperative days, the patient was asked to color the mandala drawing of his choice from the booklet as many times as he wanted. However, they were asked to practice at least one mandala activity every day. For painting in the mandala activity, a set of 12 colored crayons was given to the patients by the researcher and no color guidance was given for painting. The research was continued by following up within 3 days, namely the zeroth, first and second postoperative days. VAS and STAI-I forms were applied before and after the mandala activity.