anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a diazepine derivative represented by general formula (I) (In the formula: R 1  and R 2  are a hydrogen atom, etc. or R 1  and R 2  together with a benzene ring to which they are attached are a naphthalene ring, etc.; R 3  and R 4  are a hydrogen atom, etc.; R 5  is a hydrogen atom, etc.; R 6  and R 7  are a hydrogen atom, etc.; X is C, CH or N and Y is N, NH or C (=O), provided that when X is N, Y is not N or NH and when X is C or CH, Y is not C (=O); Z is an oxygen atom or a sulfur atom; A is a benzene ring, etc.; B is NHC (=O), etc.; D is an atomic bonding, etc.; E is an atomic bonding, etc.; G is benzene which may by substituted, etc.; and m is an integer of 0 to 5.) or a pharmaceutically acceptable salt thereof, and a P2X4 receptor antagonist.
BACKGROUND: Limited research suggested that liver cirrhosis is an independent risk factor for severe COVID-19, leading to higher hospitalization and mortality rates. This study aimed to identify the prognostic factors and validate scoring systems for predicting mortality in COVID-19 patients with liver cirrhosis.
METHODS: This retrospective cohort study extracted electronic health records of patients with COVID-19 who visited the emergency department between April 2021 and September 2022. Adult COVID-19 patients with liver cirrhosis were included, excluding those aged < 18 years and who did not require hospitalization. The primary outcome was in-hospital mortality. The effectiveness of the scoring systems were analyzed for COVID-19 in-house mortality prediction.
RESULTS: A total of 1,368 adult COVID-19 patients with liver cirrhosis were included in this study. Compared with the survival group, the non-survival group had lower vital signs such as systolic blood pressure and blood oxygen saturation, higher levels of white blood cells, creatinine, bilirubin, and C-reactive protein, and longer prothrombin time. Higher rates of intubation, oxygen use, and dexamethasone use were observed in the non-survivor group. The WHO ordinal scale, MELD, and MELD-Na scores showed good predictive ability for in-hospital mortality.
CONCLUSIONS: The WHO ordinal scale showed the best performance in predicting mortality in patients with cirrhosis and COVID-19. MELD and MELD-Na scores were also found good performance for mortality prediction. Coagulation function, intubation, and dexamethasone administration were the most significant prognostic factors.
A clear, colorless, sterile solution for injection or infusion. Each 1 ml of the solution contains 2 mg of ondansetron as hydrochloride dihydrate.
PURPOSE:To prepare a remedy for ophthalmia giving low irritation to the ocular mucous membrane, in the form of ophthalmic solution, by using ketoprofen or its salt as a main component. CONSTITUTION:An ophthalmic solution having remarkably reduced irritativity to the ocular-mucous membrane is prepared by using ketoprofen or its salt as a main component, and preferably adding a basic amino acid (e.g. arginine, lysine, ornithine, histidine, etc.) to the solution. The agent does not exhibit the side effects such as stimulation of gastric mucosa caused by the general administration e.g. oral administration, and gives high local concentration of the active component.
The EVLA will be performed with the 1470nm diode laser and a radial fibre (Leonardo® - 1470 nm/15W, Biolitec). The exact position of the catheter tip will be fixed under ultrasound guidance 2 cm below the SFJ.
OBJECTIVE: To evaluate the clinical efficacy of a single-session implantation of spinal cord electrical stimulation with neurophysiological monitoring a spinal cord electrical stimulator under general anesthesia with neurophysiological monitoring for the treatment of high-risk diabetic foot.
METHODS: The clinical data of seven patients with high-risk diabetic foot who underwent spinal cord electrical stimulation in neurosurgery ward nine of Tianjin Huanhu Hospital from May 2022 to May 2023 were collected. The operation was performed under general anesthesia with the "C" arm X ray machine guidance and neurophysiological monitoring. The arterial diameter and peak flow rate of lower extremity, lower extremity skin temperature (calf skin temperature, foot skin temperature), visual analog scale (VAS), continuous distance of movement, blood glucose level and toe wound were compared between patients before and after surgery.
RESULTS: A total of seven patients with high-risk diabetic foot were included. The diameters and peak flow rates of femoral artery, popliteal artery, anterior tibial artery, posterior tibial artery and dorsal foot artery in both lower limbs were significantly improved after surgery. All patients had different degrees of lower limb pain before operation. After operation, VAS score decreased significantly (1.1±0.9 vs. 6.8±3.4), the pain was significantly relieved, and the calf skin temperature and foot skin temperature were significantly higher than those before surgery [calf skin temperature (centigrade): 33.3±0.9 vs. 30.9±0.7, foot skin temperature (centigrade): 31.4±0.8 vs. 29.1±0.6], fasting blood glucose and postprandial blood glucose were significantly lower than those before surgery [fasting blood glucose (mmol/L): 7.6±1.4 vs. 10.5±1.2, postprandial blood glucose (mmol/L): 9.3±2.3 vs. 13.5±1.1], the differences were statistically significant (all P < 0.01). The lower limb movement of all seven patients was significantly improved after surgery, including one patient who needed wheelchair travel before surgery, and one patient who had intermittent claudication before surgery. Among them, one patient needed wheelchair travel and one patient had intermittent claudication before surgery. All patients could walk normally at 2 weeks after operation. Among the seven patients, two patients had the diabetic foot wound ulceration before surgery, which could not heal for a long time. One month after surgery, blood flow around the foot wound recovered and the healing was accelerated. The wound was dry and crusted around the wound, and the wound healed well.
CONCLUSIONS: For diabetic high-risk foot patients who are intolerant to diabetic peripheral neuralgia and local anesthesia spinal cord electrical stimulation test, one-time implantation of spinal cord electrical stimulator under general anesthesia under neurophysiological monitoring can effectively alleviate peripheral neuralgia and other diabetic foot related symptoms, improve lower limb blood supply, and reduce the risk of toe amputation. Clinical practice has proved the effectiveness of this technique, especially for the early treatment of diabetic high-risk foot patients.
The invention relates to the medicine, in particular, to obsterics and gynecology and may be used, to the prophylaxis of the wound infection. The summary of the invention consists in the fact that before the operation field is irradiated with the helio-neon lazer rase, the capacity of which is 20-25 mW during 1-2 days, 15- 20 min/day. During the operation field is irrigated with the sodium hypochlorite with the concentration of 1100 mg/l. After the operation the field of the post- operational wound is irrigated with sodium hypochlorite solution during 1-5 days, the concen- tration of which is 1100 mg/l, the irrigation is effectuated by the method of humide- drying bandage and is irradiated with lazer infrared rase having a capacity of 50 mW, 15min/day. The technical result of the proposed method consists in the improvement of the microcirculation in the tissues of the post-operational intervention field, in the increasing of phagocitosis activity and in the bactericide influence on the post- operational wound. Claims: 1
Cow Milk allergy is one of the most frequent pediatric food allergy and occurs during the first months of life. It is due to an inappropriate reaction of immune system against the human body. Its treatment is the avoidance of the cow milk proteins. Its spontaneous recovery occurs mostly during the first years of life with the decreasing of the specific IgE and the clinical tolerance to cow milk proteins.

Two shorts cas reports (3 and 5 patients) have described a clinical form of IgE-mediated cow milk allergy with angio-oedema of hands and feet. This clinical form is associated with more increasing of specific IgE against lactoserum proteins than caseine's. However it has been showed that casein is a marker of cow milk allergy persistence. It might be possible that this atypical form of cow milk allergy progresses favorably towards a restoration of tolerance earlier than the clinical form without angio-oedema of the extremities
Placebo tablet by mouth daily for 6 months. Patients under the weight of 60 kg: placebo tablet daily for 5 days per week for 6 months.
The present invention relates to a metabolic syndrome AI family doctor system which is connected to a medical institution server, a user institution server, and healthcare big data and is in communication with a metabolic syndrome care target terminal to collect lifelogs and provide disease information. The metabolic syndrome AI family doctor system comprises: a metabolic syndrome AI family doctor server which predicts disease risk based on lifelog information collected for a medical service recipient and recommends diet/exercise to the same; a service portal which provides the various services; an open PHR platform; and a cloud. The metabolic syndrome AI family doctor server comprises: a normal group care unit, a caution group care unit, and a syndrome care unit which are divided for respective metabolic syndrome care recipients to manage the same; and an AI algorithm which processes and provides AI-based prescriptions related to prevention, complications, and customized prescriptions based on lifelog data collected by classified subjects. The metabolic syndrome care target terminal accesses the metabolic syndrome AI family doctor system through a wired or wireless communication network to receive a patient service. The healthcare device includes a thyroid hormone measuring unit, a blood pressure measuring unit, a blood sugar measuring unit, a lipid (HDL, triglyceride) measuring unit, a smart band (exercise, heart rate, sleep), and a PHR standard interface. The metabolic syndrome AI family doctor system is capable of contributing to creating and expanding new jobs for healthcare workers by activating the digital healthcare industry and community healthcare.
The present invention discloses the application of scutellaria extracts to the preparation of medicine for resisting esophagus cancer, and the scutellaria extracts particularly refer to extracts with a flavone mother body structure, can be scutellarin or scutellaroside, or can be a mixture of scutellarin and scutellaroside and salts prepared from scutellaria extracts and accepted in pharmacy. The medicine prepared from scutellaria extracts for resisting esophagus cancer can directly inhibit the division of cancer cells, and perform the function of strongly inducing the apoptosis of cancer cells. The medicine has no obvious effect on growth period and apoptosis of normal cells. Moreover, the medicine also performs the function of inhibiting vascularization inside esophagus cancer, particularly revascularization in oxygen deficiency environment; consequently, the blood supply of esophagus cancer is effectively cut off so that stomach cancer is denatured and necrosed. The medicine obviously inhibits and kills the growth of transplanted esophagus cancer, and has no toxic or side effect. The scutellaria extracts have very positive practical significance for preparing medicine for treating or preventing esophagus cancer.
LSALT peptide (1mg/mL in 0.9% saline) Dose will be determined based on results of SAD arm. LSALT will be administered intravenously once or twice daily for 3 days.
The invention discloses a traditional Chinese medicine of rheum officinale and cuttlebone powder for treatment of chronic gastritis, and mainly solves problems of present medicine for treatment of chronic gastritis that the curative effect is poor and side-effects also exist. The traditional Chinese medicine of rheum officinale and cuttlebone powder is produced by the following steps: taking 30g rheum officinale, 150g cuttlebone and 60g liquorice; and drying and grinding the ingredients above into fine powders respectively. Dosage and administration are that: 3g each time, and three times a day for adults. The dosage is decreased accordingly for children. The traditional Chinese medicine of rheum officinale and cuttlebone powder has advantages that: effective rate for treatment of chronic gastritis is 95% or more, and cure rate is 80% or more; and the traditional Chinese medicine of rheum officinale and cuttlebone powder has no toxic or side effects. [0]
Methods of reducing and/or protecting against disorders in perinatal subjects are disclosed. Such methods can be used for disorders associated with neuronal cell damage. In certain aspects, the method comprises administering a therapeutically effective amount of neuregulin or a biologically active analog with a pharmaceutical carrier to a perinatal subject. In addition, the perinatal subject can be a fetus where the neuregulin is administered to the pregnant mother. Methods for assessing whether a perinatal subject is at risk for developing a neurological disorder are also disclosed. For example, expression levels of neuregulin can be used as an indication the perinatal subject is at risk for developing a disorder associated with neuronal cell damage. Evaluating the genotype of the NRG locus in a perinatal subject can also be used as an indicator of the risk of developing neurological disorders.
N6-methyladenosine (m6A) is one of the most abundant epitranscriptomic modifications on eukaryotic mRNA. Evidence has highlighted that m6A is altered in response to inflammation-related factors and it is closely associated with various inflammation-related diseases. Multiple subpopulations of myeloid cells, such as macrophages, dendritic cells, and granulocytes, are crucial for the regulating of immune process in inflammation-related diseases. Recent studies have revealed that m6A plays an important regulatory role in the functional of multiple myeloid cells. In this review, we comprehensively summarize the function of m6A modification in myeloid cells from the perspective of myeloid cell production, activation, polarization, and migration. Furthermore, we discuss how m6A-mediated myeloid cell function affects the progression of inflammation-related diseases, including autoimmune diseases, chronic metabolic diseases, and malignant tumors. Finally, we discuss the challenges encountered in the study of m6A in myeloid cells, intended to provide a new direction for the study of the pathogenesis of inflammation-related diseases.
This is a study of the effects of weight loss and exercise training on glucose control as measured by the Hemoglobin A 1 C in individuals with recently diagnosed Type 2 Diabetes. Study outcomes are measured at 6 months. The primary outcome is the HBA1c at 6-months. Secondary outcomes include body weight, fitness, lipid profiles and HS-CRP, a measure of inflammation. The study hypothesis is that the program of weight loss and exercise will put \>50% of individuals into "remission" of their type 2 Diabetes as measured by a HBA1c of \< 6.5%.

The study replicates the clinical situation where selected patients with new type 2 diabetes, who are motivated to try an intensive lifestyle intervention, might replicate our study intervention if we are able to show a high remission rate (e.g. \> 50%) for individuals in the study.
Radiotherapy is an important treatment for breast cancer patients. About 95% of patients receiving radiotherapy will develop a degree of radiation dermatitis. Radiation dermatitis is usually limited to the site of radiation treatment. Symptoms vary and can range from itching, burning and pain to open or bleeding ulcers, which can greatly affect the quality of life of patients. Severe acute radiation dermatitis can lead to interruption or delay of treatment. At present, there is no standard for the prevention and treatment of radiation dermatitis. Our skin is home to millions of bacteria, fungi and viruses which compose the skin microbiota. Skin microbiota interacts with skin and affects physiology and immunity of the skin. Previous studies have reported the effects of radiotherapy on skin and immune system. However, so far, no studies have analyzed the effects of radiotherapy on skin microbiome and how skin microbiome affects the skin immune responses after radiotherapy. In this study, the breast cancer patients who received radiotherapy after mastectomy and breast reconstruction will be enrolled. The skin microbiome before radiotherapy and its changes after radiotherapy will be analyzed systematically to find out whether the skin microbiome is associated with the severity of radiation dermatitis. The long-term goal of this study is to deepen the understanding of the role of skin microbiome in the occurrence and development of radiation dermatitis, and provide a basis for subsequent exploration to reduce radiation dermatitis by regulating skin microecology.
The study uses a randomized controlled trial design stratified by provider to assess the impact of an adolescent "asthma question prompt list" combined with a supportive educational video emphasizing the importance of adolescent involvement and question-asking on communication during pediatric visits. This application is based on Social Cognitive Theory. Self-confidence or self-efficacy is a central component of Social Cognitive Theory (SCT) Application of Social Cognitive Theory (SCT) in asthma populations has shown that technical advice from providers is one external factor that can improve asthma management self-efficacy. Additionally, personal beliefs, such as outcome expectations, and family factors, such as parent and adolescent responsibility for asthma self-management, have been shown to affect adolescent self-efficacy and disease management outcomes. Prior work has found that adolescent self-efficacy in asthma management correlates strongly with health status, adherence, asthma medication device technique, asthma symptoms, and impact of illness on the family.

All adolescents will have their medical visits audio recorded. The adolescent will be interviewed after his/her medical visit while his/her caregiver/parent completes a survey at the time of study enrollment. This same procedure will be used when the adolescent and caregiver/parents return for the 6- and 12-month follow-up visits.
Morphine sulfate extended-release tablets are for oral use and contain morphine sulfate, an opioid agonist.

Each tablet contains the following inactive ingredients common to all strengths: lactose monohydrate, hypromellose, magnesium stearate, colloidal silicon dioxide, polyethylene glycol, titanium dioxide, polydextrose, and triacetin.

The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate). The 15 mg tablets also contain: FD&C Blue No. 2

The 30 mg tablets also contain: D&C Red No. 7, FD&C Blue No. 2

The 60 mg tablets also contain: D&C Yellow No. 6 and red iron oxide.

The 100 mg tablets also contain: black iron oxide

Morphine sulfate is an odorless, white, crystalline powder with a bitter taste. It has a solubility of 1 in 21 parts of water and 1 in 1000 parts of alcohol, but is practically insoluble in chloroform or ether. The octanol: water partition coefficient of morphine is 1.42 at physiologic pH and the pK bis 7.9 for the tertiary nitrogen (mostly ionized at pH 7.4). Its molecular weight is 758.83 and its structural formula is:
The invention discloses the use of Xiaomeng oculentum in the preparation of medicines for treating alopecia areata. The formula of Xiaomeng oculentum comprises pearl powder, borneol and borax. The preparation method of Xiaomeng oculentum comprises: sieving pearl powder with a No.9 mesh, disinfecting pearl powder under a high pressure (121 DEG C, 15 pounds), taking the pearl powder out, drying the pearl powder and sealing the pearl powder for later use; grinding borneol and borax into fine powder, sieving the fine powder, and sterilizing the fine powder for later use; and preparing a substrate from a proper amount of vaseline, wool grease and liquid paraffin according to a ratio of (8:1:1), heating the substrate to 150 DEG C, keeping the temperature for 1.5 hours, filtering, adding the medicinal powder when the mixture is cooled to about 60 DEG C, mixing uniformly and thus obtaining Xiaomeng oculentum which is almost white or yellowish to yellow. Xiaomeng oculentum offers a special fragrance. Xiaomeng oculentum is packaged by a specification of 2.5 grams. Xiaomeng oculentum is to be applied onto affected parts and can treat alopecia areata through external application.
Arthrofibrosis is a challenging complication associated with knee injuries in both children and adults. While much is known about managing arthrofibrosis in adults, it is necessary to understand its unique aspects and management strategies in the pediatric population. This paper provides an overview of arthrofibrosis in pediatric orthopedic surgery, focusing on its causes, implications, classifications, and management. This paper is a comprehensive review of the literature and existing research on arthrofibrosis in pediatric patients. Arthrofibrosis is characterized by excessive collagen production and adhesions, leading to restricted joint motion and pain. It is associated with an immune response and fibrosis within and around the joint. Arthrofibrosis can result from various knee injuries in pediatric patients, including tibial spine fractures, ACL and PCL injuries, and extra-articular procedures. Technical factors at the time of surgery play a role in the development of motion loss and should be addressed to minimize complications. Preventing arthrofibrosis through early physical therapy is recommended. Non-operative management, including dynamic splinting and serial casting, has shown some benefits. New pharmacologic approaches to lysis of adhesions have shown promise. Surgical interventions, consisting of arthroscopic lysis of adhesions (LOA) and manipulation under anesthesia (MUA), can significantly improve motion and functional outcomes. Arthrofibrosis poses unique challenges in pediatric patients, demanding a nuanced approach that includes prevention, early intervention with non-operative means, and improvements in surgical techniques. Modern pharmacological interventions offer promise for the future. Customized interventions and research focused on pediatric patients are critical for optimal outcomes.