anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Families randomized to the Family Check-Up arm will be connected with a clinician who will provide the Family Check-Up. The Family Check-Up® (FCU) is an ecologically sensitive, evidence-based intervention that was developed to decrease childhood EBP by 1) assessing known ecological (child, family and contextual) risk and protective factors; 2) engaging parents in a tailored plan to enhance positive parenting and family management skills; and 3) connecting families to a tailored suite of child and family services and supports. Services may include an evidence-based suite of parenting sessions ("Everyday Parenting Curriculum \[EPC\]") created by FCU developers for direct tailoring to the FCU feedback session.
Every patient will receive a general anesthesia induced with propofol (1.5-2.5 mg/kg, individually adjusted), rocuronium (0.6 mg/kg) for muscle relaxation and a continuous infusion of remifentanil (0.05-0.3 mcg/kg/min, depending on the clinical characteristics of the patient). General anesthesia was maintained with a continuous infusion of propofol (4-8 mg/kg/h), and the infusion of remifentanil which was started with the induction. Fractionated doses of rocuronium were administered based on TOF monitoring (train of four) to maintain muscle relaxation.
A single chain variable fragment (scFv) antibody against glucose-regulated protein 78 (GRP78, or BiP) is provided. The antibody fragment may be used in the diagnosis of cancer or tumour cells, as it is upregulated in response to increased nitric oxide synthase activity and hence higher NO concentrations. The anti-GRP78 fragment may also be used in the treatment of cancer, possibly in combination with another radiotherapeutic or chemotherapeutic such as etoposide. A particular antibody defined by amino acid SEQID No:I or DNA SEQID No: 2 is provided. The antibody fragments have been isolated from phage libraries against a recombinant GRP78 protein. Treatment of cells with the antibody abolished NO-mediated cytoprotection and increased apoptosis in prostate cancer and colon cancer cell lines, enhanced by combination with etoposide.
1377609 3α - Hydroxy - 5α - pregnanecompounds GLAXO LABORATORIES Ltd 16 Dec 1971 [17 Dec 1970] 60066/70 Heading C2U [Also in Division A5] Novel 5α-pregnanes possessing a 3α-hydroxy group, a 10-hydrogen atom or methyl group, an 11-oxo group, a 17α-hydrogen atom, a 20-oxo group and at the 21-position a chlorine or iodine atom or a group -XR where XR is O.COR, O.CO.OR, O.CO.SR or O.CO.NHR and R is a nitrobenzyl group, a C 1-6  alkyl group when X is not O.CO, a halogenoalkyl group or a hydrocarbon group substituted by an amino group or a nitrogen-containing heterocyclic group are prepared (a) when the 21-substituent is to be -XR, (i) by esterification of the corresponding 21-ols or steroids possessing a readily eliminatable 21- substituent, with possible protection of the 3α-hydroxy group, e.g. as the nitrate ester, (ii) when R is to be an amino alkyl group, by reacting a corresponding 21-alkanoyloxy steroid containing a readily eliminatable substituent with an appropriate amine, (iii) when R is to be an iodoalkyl group, by reacting a corresponding chloralkyl compound with an iodide, (iv) when R is to be an aryl or aralkyl group substituted by an NH 2  group, by reduction of a corresponding nitro-aryl or -aralkyl compound, (v) when X is to be -OCOS or -OCONH, by reacting a corresponding 21-ol with a carbonyl halide in the presence of an acid binding agent and reacting the product with a thiol RSH or an amine RNH 2 , with intermediate 3-ol protection, or (vi) by stereospecific reduction of the corresponding 3-ones; and (b) when the 21-substituent is to be a Cl or I atom, by reacting a corresponding 21-ol or 21-Br compound with an alkali metal iodide and, when required, reacting the 21-I steroid thus formed with an alkali metal chloride. In process (i) a free NH 2  group may be protected, e.g. as a benzyloxycarbonyl derivative, and subsequently released. Products may be converted into acid-addition salts.  21-Bromo-steroid starting materials are prepared by bromination of the corresponding 21- unsubstituted steroids. 21 - Hydroxy - 3α - nitro - oxy - 5α - pregnane- 11,20-dione is prepared by hydrolysis of the corresponding 21-acetoxy compound, in turn prepared from the free 3α-ol and fuming nitric acid. 21-Hydroxy-2#-methoxy-3α-nitro-oxy-5α- pregnane-11,20-dione is prepared by hydrolysis of the corresponding 21-acetoxy compound, in turn prepared from the 21-bromo compound (prepared by nitration of the free 3α-ol) and potassium acetate. 3α-Hydroxy-2#-methoxy-5α-pregnane-11,20-dione is prepared from 2α,3α-epoxy- 5α-pregnane-11,20-dione and methanol. The novel steroids are anaesthetics, hypnotics and sedatives and they may be made up into pharmaceutical compositions with suitable carriers.
After approval from the instution's Ethics Committee, a prospective cohort study was conducted between November 2017 to March 2018. Twenty-five anesthesia residents were participated in this study. Students were noticed about the simulation classes which are emergencies in pediatric anesthesia and complications at one-month prior the day of practice. The list of standard references was given. On the day of study, at the institute's simulation center, students were voluntarily separated into two groups, directed- learner and observer. Post class debriefing sessions were done as routine activities. After the class, the investigator invited the students to be enrolled in this study by using the flyers. Following the consent process, three consecutive questionnaires (day 0 ,30, 90) were sent to the subjects. The data analysis will be done by using R program. The statistically significance in this study was classified at p \<0.05.
The present invention relates to a traditional Chinese medicine foot bath agent for cleaning and healthcare. The compounding ratio of rhubarb to menthol is 93 to 97: 7 to 3 according to the weight percentage. Chuanxiong rhizome, dahurian angelica roots, aucklandia roots and borneol are added. The compounding ratio of the rhubarb to the menthol to the chuanxiong rhizome to the dahurian angelica roots to the aucklandia roots to the borneol is 38 to 42: 3 to 7: 18 to 22: 18 to 22: 13 to 17: 3 to 7 according to the weight percentage. The present invention can be made into powdered drug and can also be made into the fluidextract preparation. The functions for cleanness, deodorization, foreign flavor elimination, channels dredging, collateral flow activation, metabolism enhancement, fatigue removal and health promotion can be effectively obtained.
Active repetitive transcranial magnetic stimulation (rTMS) will be delivered to the left DLPFC using the standard aiming strategy with the rTMS coil positioned using a robotic arm. In this arm, rTMS will be delivered at 10 Hz in 4 sec trains with 26 sec inter-train intervals, 37.5 minutes/session (i.e. 3,000 pulses/session), 5 sessions/week, for 4 weeks.
Participants aged 2-25 years will receive placebo matching to risdiplam for 12 months. After 12 months of treatment with placebo, participants will be switched to risdiplam (5 mg once daily for participants with a body weight (BW) \>/=20kg or 0.25 mg/kg for participants with a BW \<20) in a blinded manner and participants will continue with treatment until Month 24. After Month 24, participants will be offered the opportunity to enter the open-label phase.
A core material such as animal tissue or cells is contained within a semipermeable vessel which may be a microcapsule, hollow fiber or plastic membrane having a semipermeable wall by a method that prevents the core material from incorporation into the wall of the vessel. This is accomplished by suspending the core material in a solution of polysaccharide gum such as an alkali metal alginate in an amount between about 0.2% and about 0.5%, removing and washing the core material to remove all but a thin layer of polysaccharide gum, and gelling the polysaccharide gum with multivalent cations or other means to form a pretreated core material. The pretreated core material is contained within a semipermeable vessel such as by suspending the pretreated core material in a solution of alkali metal alginate, forming the suspension into droplets, gelling the droplets to form temporary shape-retaining capsules and treating the capsules with a polymeric material having groups that react with and crosslink acid groups of the capsules to form a permanent semipermeable membrane around the capsules. A second permanent semipermeable membrane may be formed around the capsules to form double-walled microcapsules by further treating the capsules with the polymeric material. The semipermeable vessel may be impermeable to immune factors. Cells or tissue can be transplanted from a donor to a subject such as by using pancreatic islet tissue or cells as the core material of the double-walled microcapsules and transplanting the microcapsules by intraperitoneal injection into a diabetic subject.
Sudden death in infants remains a common and poorly understood cause of childhood mortality in the USA. Pediatric cardiac tumors, although rare, may underlie some cases of unexplained sudden infant death. Autopsy is a crucial diagnostic step in these cases, as both gross and microscopic examination of the heart may uncover occult cardiac tumors. Rhabdomyomas are the most common cardiac tumors in childhood and may result in arrythmia and sudden death. We present a case of sudden death in a healthy 5-month-old infant which initially appeared "SIDS-like" until thorough histological analysis revealed an underlying cardiac rhabdomyoma. The case is of particular importance in that the gross examination of the heart was considered completely normal, and the tumor only involved certain portions of the heart microscopically. Had a single random section of myocardium been the only heart section examined microscopically, the diagnosis might have been missed. This case emphasizes the importance of thorough microscopic examination in infant cases, especially in cases where the heart appears grossly normal.
In the process, a suspension of a medicament of (I) in a soln. of the enrobing agent which is insol. in water but sol. in a homogeneous or heterogeneous org. solvent, pref. 1-6C alcohol is evaporated slowly to form the product, the org. solvent having a dielectric constant of 35E, pref. 10E, the enrobing agent being more sol. in the solvent than (I) and the enrobing agent showing an electrostatic affinity towards (I). Solvents are alkanols, ketones, esters and chlorinated hydrocarbons, (I) include semi-synthetic penicillins, alkaloids, sulphonamides and barbiturates and the enrobing agents are resins and/or polymers. Evapn. is effected by allowing droplets to fall under gravity in an enclosed tower under controlled conditions of temp. and vapour press. Thus ampicullin coated with a polymer of diethylamino ethyl methacrylate is prepd. from a suspension of the penicillin in a soln. of polymer in C2Cl4.
This study is a single arm pre-post evaluation of a six-session telephone-administered cognitive-behavioral therapy (CBT) intervention for anxiety in older adults with cancer and their primary informal (unpaid) caregiver. The primary purposes of this study are to evaluate the feasibility of the intervention and study procedures, acceptability of the intervention to older adults with cancer and their primary informal caregiver, and patient and caregiver adherence to the intervention. The secondary purpose is to examine changes in patient and caregiver anxiety, depression, distress, and quality of life pre to post intervention to determine whether the intervention has a clinically significant impact on these outcomes. Anxiety is the primary outcome; depression, distress, and quality of life are secondary outcomes. Patients will be 65 years of age or older and will be recruited from the myeloma, lung, lymphoma, gynecologic, and gastrointestinal cancer clinics at a single institution. Study measures will be administered by telephone prior to initiating the intervention (pre-intervention) and following intervention completion (post-intervention).
Intra-amniotic infection (IAI) is an acute bacterial infection of the amniotic fluid and intrauterine contents during pregnancy and occurs in 4% to 10% of all deliveries (Newton, ER., 1993. Newton, ER, et al., 1989. Soper, DE, et al., 1989). IAI is an important cause of maternal and neonatal morbidity. Identifying and appropriately treating women with IAI is, therefore, a major obstetrical challenge.

Intrauterine infection may occur early in pregnancy and remain undetected for a prolonged period, thus exposing the fetus to the effects of infection/inflammation for a considerable period. Ideally, an early diagnosis of IAI is important to allow timely treatment and intervention. Unfortunately, the early diagnosis is difficult because the clinical signs and symptoms of IAI may occur late in the course of the infection and are neither sensitive nor specific. Therefore, to avoid a delay in diagnosis a high degree of suspicion and the appropriate use of adjunctive laboratory tests are warranted.
OBJECTIVE: Full endoscopic techniques are being gradually introduced from single-segment cervical disc herniation surgery to two-segment cervical disc herniation surgery. However, there is no suitable full endoscopic treatment for mixed-type two-segment cervical disc herniation (MTCDH) in which one segment herniates in front of the spinal cord and the other segment herniates behind the spinal cord. Therefore, we introduce a new full endoscopic technique by combining an anterior transcorporeal approach and a posterior translaminar approach. In addition, we provide a brief description of its safety, efficacy, feasibility, and surgical points.
METHODS: Thirty patients with MTCDH were given full endoscopic surgical treatment by a combined transcorporeal and transforaminal approach and were followed up for at least 12 months.
RESULTS: Clinical assessment scales showed that the patient's symptoms and pain were significantly reduced postoperatively. Imaging results showed bony repair of the surgically induced bone defect and the cervical Cobb angle was increased. No serious complications occurred.
CONCLUSION: This technique enables minimally invasive surgery to relieve the compression of the spinal cord by MTCDH. It avoids the fusion of the vertebral body for internal fixation, preserves the vertebral motion segments, avoids medical destruction of the cervical disc to the greatest extent possible, and expands the scope of adaptation of full endoscopic technology in cervical surgery.
This arm will include patients with and surviving cancer who are seen during the Post-Implementation study period, once the routine sexual function screening intervention has been implemented. It will include patients diagnosed prior to age 18 years and 15-24 years old at the time of study. Patients will be approached by research personnel at the end of each visit for participation in a survey. The post-implementation survey will assess sexual function communication and patient satisfaction, as well as measures of acceptability, feasibility, and appropriateness of the intervention. In addition, medical record data abstraction of clinical care related to sexual health and function will be collected.
Functional transcranial dopplerography (FTCD) is a non-invasive ultrasound examination that allows recording the dynamics of cerebral blood flow parameters under conditions of factors stimulated the activity of the structures of the central nervous system. Judgments about the sensitivity and specificity of FTCD are based on the close connection between changes in the activity of the nervous (somatic) system and the response of regional cerebral blood flow (CBF). The technique is a portable and accessible diagnostic method used in assessing the possibility of expanding functional activity during the recovery period after a stroke. An increase in mental activity in response to the presentation of a cognitive task, accompanied by an increase in glucose and oxygen consumption and naturally requiring an increase in cerebral perfusion parameters, can also be assessed by changes in regional blood flow parameters while maintaining the reactive mechanisms of autoregulation. A search of literature sources was carried out in the electronic databases PubMed and Scopus. For the subject search, Medical Subject Headings were used. A total of 36 sources that mentioned the terms «cognitive function» and «functional transcranial Doppler» were selected for preliminary analysis. At the present stage, methodological problems are obvious, requiring the development and implementation of a standard package of targeted functional tests to assess cognitive status. Available equipment and software require technological solutions to ensure objective recording of changes in cerebral blood flow during testing and training.
Exercises were taught in the supine position, as described by Kegel (1948), and it was confirmed that the women learned to use the correct muscles with vaginal palpation. During the exercise, the participants were informed not to pull the abdomen inwards, not to tighten their legs and hip muscles, and not move their pelvis.
Patients with persistent postural-perceptual dizziness (PPPD) perceive postural instability larger than the observed sway. It is unknown whether the concept of postural misperception prevails during vestibular stimulation and whether it may account for the unsteadiness patients complain during body movements. We tested the hypothesis of an abnormal sensory-perceptual scaling mechanism in PPPD by recording objective, perceived, and the reproduced postural sway under various standing conditions, modulating visual and proprioceptive input, by binaural galvanic vestibular stimulation (GVS). We related postural sway speed to individual vestibular motion perceptional thresholds and disease-related PPPD questionnaires in 32 patients and 28 age-matched healthy control subjects (HC). All participants showed normal vestibular function tests on quantitative testing at the time of enrollment. The perception threshold of GVS was lower in patients. Compared to HC, patients showed and perceived larger sway on the firm platform. With GVS, posturo-perceptual ratios did not show group differences. The ratio of reproduced to real postural sway showed no group differences indicating normal postural sway perception during vestibular stimulation. Noticeably, only in patients, reproduced postural instability became larger with lower individual thresholds of vestibular motion detection. We conclude that posturo-perceptual (metacognitive) scaling of postural control seems to be largely preserved in PPPD during GVS. Vestibular stimulation does not destabilize patients more than HC, even in challenging postural conditions. Low individual thresholds of vestibular motion perception seem to facilitate instability and postural misperception on solid grounds. This conclusion is important for an effective physical therapy with vestibular exercises in PPPD.
Photobiomodulation is a safe option for controlling pain, edema, and trismus when applied postoperatively in third molar surgery. However, administration prior to surgery has been under-explored. This study aims to explore the effectiveness of pre-emptive photobiomodulation in reducing postoperative edema in impacted lower third molar extractions. Two groups of healthy individuals undergoing tooth extraction will be randomly assigned: Control group receiving pre-emptive corticosteroid and simulated photobiomodulation, and Photobiomodulation Group receiving intraoral low-intensity laser and extraoral LED cluster application. The primary outcome will be postoperative edema after 48 h. The secondary outcomes will be pain, trismus dysphagia, and analgesic intake (paracetamol). These outcomes will be assessed at baseline as well as two and seven days after surgery. Adverse effects will be recorded. Data will be presented as means ± SD and a p-value < 0.05 will be indicative of statistical significance.
PURPOSE:A pharmaceutical, containing active vitamin D3 such as 1alpha-hydroxycholecalciferol, 1alpha-24-dihydroxycholecalciferol, etc. as an active constituent, and very useful for treating diabetic osteopenia. CONSTITUTION:A remedy for diabetic osteopenia containing active vitamin D3 such as 1alpha-hydroxycholecalciferol, 1alpha-24-dihydroxycholecalciferol, etc. in an amount of 0.1-10mug. The administration of the active vitamin D3 remarkably increases the mineral content in bones of a patient with a diabetic osteopenia, e.g. osteoporosis or osteomalacia, as compared with a patient suffering from usual osteopenia and therefore is very useful for treatment. The above-mentioned remedy is preferably in the form of oral administation, e.g. gelatin soft capsule.
Ten infants (1-12 months of age) treated with propranolol will be identified from a Dermatology Database. Patients will be considered as controls if they were treated with propranolol before 1 year of age and had digital photography documentation of their hemangioma.
Random numbers will be generated by an independent biostatistician in a 1:1 ratio, sealed in sequentially numbered opaque envelopes, and stored by a study coordinator. Only anesthesiologists who perform paravertebral block know group allocation but are not involved in other parts of the trial. Patients, other health-care team members, and investigators for data collection and outcome assessment are masked from group assignments.

Paravertebral block will be performed with either liposomal bupivacaine or plain bupivacaine. The efficacy of nerve block will be assessed every 5 minutes after local anesthetic injection. We will evaluate pain severity, opioid consumption, and occurrence of adverse events at the following timepoints, i.e., end of surgery, 30 minutes after surgery, and 2, 6, 12, 24, 36, 48, 60, and 72 hours after surgery. Additionally, occurrence of complications, quality of recovery, and subjective sleep quality will be assessed during hospital stay after surgery.
AIM: Post-operative pain may occur after non-surgical root canal treatment (NSRCT). The root filling technique and choice of sealer may be contributing factors. This randomized controlled clinical trial compared post-operative pain and analgesics intake after NSRCT using a sealer-based obturation technique (SBO) with single-cone gutta-percha and calcium silicate sealer (CSS) versus a warm-vertical compaction (WVC) technique with gutta-percha and a resin-based sealer (RBS).
METHODOLOGY: This study was designed as a parallel-two arm, double-blind, randomized superiority clinical trial registered at www.
CLINICALTRIALS: gov (NCT04753138). Patients referred for NSRCT fulfilling the inclusion criteria participated in this study. Pre-operative periapical radiographs and CBCT scans were taken and numerical rating scale (NRS) pain scores were recorded. Upon completion of canal instrumentation, participants were randomly allocated to either Group SBO: SBO with CSS or Group WVC: Warm-vertical compaction with RBS. Post-operative pain and analgesics intake were recorded at 1, 3 and 7 days after endodontic treatment completion. Non-parametric Mann-Whitney U and Friedman tests and a generalized estimating equation were used to assess differences in pain scores between the groups, within each treatment group at different time points and for correlations, respectively.
RESULTS: The study included 195 participants (212 teeth). One participant declined to submit the NRS form. Therefore, 194 participants (211 teeth) were included in the final analysis (99.5% response rate). No statistically significant differences in post-operative pain or analgesic intake existed between the two groups at any time point (p > .05). Age, pre-operative pain, apical diagnosis and post-operative analgesic intake were significantly related to post-operative pain (p < .05).
CONCLUSIONS: Sealer-based obturation technique with CSS was associated with similar post-operative pain levels and analgesics intake as WVC with RBS. Regarding post-operative pain, SBO with CSSs may be a suitable clinical alternative.