anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Actually, there is no data concerning the impact of chlordecone on the evolution of fibrosis to cirrhosis in chronic hepatitis whereas many studies have been reported liver damage in mice. The goal of this study is to know if co-exposition to chlordecone can induce evolution to cirrhosis in chronic hepatitis due to alcohol or viral hepatitis. At first, we will assess a group of patients with chronic hepatitis B, C or due to alcohol without fibrosis. And they will be compared to patients with cirrhosis exposed to chlordecone too. Patients will be included in 2 hospital centers. All these patients should have an active liver disease. The activity will be defined by histology or elevated transaminases (\>2N), fibrosis will be defined by histology or an association of fibroscan and biological markers. Exposition to chlordecone will be evaluated by a blood chlordecone measure for every patient.
A method for determining a step count is disclosed. The method includes determining a motion pattern of a user after initiation of a walking activity. The method includes detecting one or more false steps and a gait abnormality associated with a user. The method includes detecting an arm swing angle and a leg swing angle of the user based on the motion pattern. The method includes estimating a first variation in the arm swing angle and a second variation in the leg swing angle during the walking activity. The method includes calculating a compensation value associated with the one or more false steps, based on a combination of the first variation, the second variation, and a height of the user. The method includes determining the step counts of the user based on the calculated compensation value to an initial step count of the user.
BACKGROUND: Urinary tract infections (UTIs) are prevalent amongst paediatric patients, and they can lead to emergency department (ED) visits. A subset of patients requires a second ED visit, creating a burden on healthcare resources. This study aimed to shed light on the clinical, laboratory, treatment-related and environmental determinants associated with the recurrence of ED visits in this specific paediatric population.
METHODS: This single-centre retrospective study involved paediatric patients diagnosed with UTIs and admitted to the paediatric ED of our hospital from September 2021, to August 2023. In accordance with whether a second visit was required, the ED patients were grouped into non-second-visit group or second-visit group. The demographic, clinical, laboratory, diagnostic, and environmental factors were analysed in detail. Statistical analyses, including chi-square tests, t-tests and correlation analyses, were employed to assess the associations between various factors and subsequent ED visits.
RESULTS: A total of 357 patients, including 324 patients without a second visit and 33 patients with a second visit, were included in this study. Factors significantly associated with second ED visits included fever (≥38.5 °C) at initial presentation (p = 0.034), longer symptom duration (p = 0.022), increased C-reactive protein (CRP) levels (p = 0.018), hydronephrosis (p = 0.033) and lack of oral antibiotic use before the first visit (45.45% vs. 67.9%, p = 0.017). More bubble bath exposure (p = 0.037) and lower consultation rates with paediatric urology services (p = 0.020) were associated with repeated visits. Multifactor logistic regression analysis showed that the factors significantly associated with second ED visits were longer symptoms duration, fever (≥38.5 °C) at initial presentation, presence of flank pain, increased CRP levels, hydronephrosis, renal stones, vesicoureteral reflux, underlying anatomical abnormalities, lack of oral antibiotic use before the first visit, bubble bath exposure and lower consultation rates with paediatric urology services.
CONCLUSIONS: A series of clinical indicators, laboratory findings, diagnostic measures and environmental factors may be associated with the need for a second ED visit amongst paediatric patients with UTI. Early antibiotic intervention, identification of underlying anatomical anomalies and management of environmental exposures may mitigate recurrent ED visits.
This invention relates to systems and methods for identifying subjects infected by viruses. Present invention is particularly directed to providing systems and methods that allow secure distribution of self-expiring health badges through a kiosk to the subjects free of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The kiosk includes a customer interface which comprises (a) a computer system; (b) a finger slot for collecting subject's blood sample and rapid testing, and (c) a badge/card printer and an output slot. The kiosk is located at a plurality sites and includes a camera to capture an image of the subject and attaches the image to self-expiring badge after the subjects are tested negative for SARS-CoV-2 infections. The self-expiring badge uses a time indicator and provides a clear indication of expiration of the badge after a predetermined period interval. Furthermore, the badge acts to prevent unauthorized usage and are re-usable.
Sepsis is a life-threatening organ dysfunction caused by an unregulated host response to infection. It is an important clinical problem in acute and critical care. In recent years, with the increasing research on the epidemiology, and pathogenesis, diagnostic and therapeutic strategies of sepsis, great progress has been made in clinical practice, but there is still a lack of specific and effective treatment plans. Curcuma longa , a leafy plant of the ginger family, which is a common and safe compound, has multiple pharmacological actions, including, but not limited to, scavenging of oxygen free radicals, attenuation of inflammatory response, and antifibrotic effects. Great progress has been made in the study of sepsis-associated rodent models and in vitro cellular models. However, the evidence of curcumin in the clinical management practice of sepsis is still insufficient; hence, it is very important to systematically summarize the study of curcumin and sepsis pathogenesis.
The invention discloses a method for appendix excision under the condition of epidural anesthesia. Through midazolam administration and fentanyl-assistant application, the method realizes appendicectomy under the condition of epidural anesthesia. According to the method, midazolam is a water-soluble benzodiazepine narcotic and is combined with a benzodiazepine acceptor of a central nervous system so that normal nerve functions are inhibited, effects of anxiety resistance, memory loss and calmness are obtained, and calming effects of other narcotics are improved. The appendicectomy is carried out under the condition of midazolam- and fentanyl-assistant epidural anesthesia so that intraoperative tractive response is reduced and patient anxiety, fear and postoperative bad memory are eliminated. Midazolam and fentanyl are combined so that fentanyl can reduce a use amount of midazolam needed by loss of consciousness, improves consciousness inhibition effects of midazolam, makes consciousness disappear at a high Bis value, has calmness and forgetting effects obviously better than those of the traditional droperidol-fentanyl compound, and has ideal and stable anaesthesia effects. The method provides humanistic service for patients.
Obesity is a pandemic that disproportionately affects children from vulnerable populations in the USA. Current treatment approaches in primary care settings in the USA have been reported to be insufficient at managing pediatric obesity, primarily due to implementation challenges for healthcare systems and barriers for families. While the literature has examined the efficacy of pediatric obesity interventions focused on internal validity, it lacks sufficient reporting and analysis of external validity necessary for successful translation to primary care settings. We conducted a systematic review of the primary-care-setting literature from January 2007 to March 2020 on family-based pediatric weight management interventions in both English and/or Spanish for children ages 6-12 years in the USA using the Reach, Efficacy/Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework. A literature search, using PRISMA guidelines, was conducted in January 2022 using the following electronic databases: Medline Ovid, Embase, and Cochrane Library. 22 270 records were screened, and 376 articles were reviewed in full. 184 studies were included. The most commonly reported dimensions of the RE-AIM framework were Reach (65%), Efficacy/Effectiveness (64%), and Adoption (64%), while Implementation (47%) and Maintenance (42%) were less often reported. The prevalence of reporting RE-AIM construct indicators ranged greatly, from 1% to 100%. This systematic review underscores the need for more focus on external validity to guide the development, implementation, and dissemination of future pediatric obesity interventions based in primary care settings. It also suggests conducting additional research on sustainable financing for pediatric obesity interventions.
PURPOSE:To provide an effective data for performing a diagnosis on a patient to a doctor by memorizing a large amt. of data related with an ultrasonic diagnosis apparatus in an external store and performing easily retrieval, summing-up, registration and calculation to the data. CONSTITUTION:A system of an ultrasonic diagnosis apparatus is constituted of an ultrasonic diagnosis apparatus main body, an ultrasonic probe 2, a card reader 3, a key board 4, a displaying apparatus 5, an external store 6 for memorizing the data and a communication apparatus 7. As the data memorized in the external store 6 have an indication 602, in performing a retrieval, a data indicated by an indication controlled by a key data has becomes a data to be aimed. In addition, a data needed for performing calculation can be summed up based on the indication 602 and as the data needed for performing a treatment in the ultrasonic diagnosis apparatus main body, the data indicated by the indication 602 controlled by the key data becomes a data to be aimed. Newly generated data is registered in the ultrasonic diagnosis apparatus 6 after it is correlated with each data. As retrieval, summing-up, registration and calculation can be easily performed, an effective data for performing a diagnosis on a patient can be provided.
UNLABELLED: Cellulite, a perceived alteration in skin topography, is predominantly found in adipose tissue-rich body regions such as the hips, buttocks, thighs, and abdomen. Contrary to common belief, the etiology and pathophysiology of cellulite are not well-established or universally agreed upon. This lack of understanding about the actual etiology of cellulite directly influences the selection of suitable treatments that can address both the aesthetic and inflammatory aspects of the condition. Various treatment methods, including electrophysical agents like electric currents, radiofrequency, ultrasound, and photobiomodulation, have been tested. However, the questionable methodological quality of many studies complicates the determination of effective treatments for cellulite. In this study, we conducted a systematic review of clinical studies that utilized electrophysical agents in cellulite treatment.
METHODS: We employed the PICO (population, intervention, control, and outcome) process to develop our search strategy and establish inclusion/exclusion criteria. We searched five databases: Medline, Central, Scopus, Lilacs, and PEDro, for studies conducted between 2001 and July 2021 that involved cellulite treatment with electrophysical agents. To ensure systematicity and guide study selection, we adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
RESULTS: Our initial search yielded 556 articles: 379 from Medline, 159 from Central, and 18 from Lilacs. After applying our inclusion criteria, only 32 studies remained. Of these, only two (6.2%) were evaluated as having strong and good methodology via the QualSyst tool.
CONCLUSIONS: Our findings indicate that the quality of evidence from clinical studies on the use of electrophysical agents for cellulite treatment remains subpar. Further studies with robust experimental designs and more precise assessment techniques are necessary. While our study does not refute the effectiveness of the techniques used for cellulite treatment, it underscores the need for additional well-designed trials.
The invention concerns human helper T cell growth factor (15) and polynucleotide encoding it. The invention also concerns the process of producing the polypeptide by recombinant DNA technique. The methods for treating many diseases e.g. malignant tumor, hemopathy, infection of HIV, immunological diseases and pruritus utilizing the polypeptide are disclosed. The invention discloses the antagonist against the polypeptide and therapeutics thereof. The invention also discloses the uses of the polynucleotide, which encodes the novel human helper T cell growth factor (15).
Cancer survivorship has been steadily improving as a result of earlier detection and improved therapies. Behind cancer recurrence, the primary cause of morbidity and mortality among survivors stems from the onset of cardiovascular disease that arises in part due to cardiotoxic chemo and radiation therapies. The increased risk of cardiovascular disease is particularly high in specific survivor populations, such as lymphoma survivors. Although exercise has been demonstrated to improve both recovery after cancer therapy and quality of life, both physical and logistical hurdles may prohibit certain patients from accessing this intervention. High-resistance inspiratory muscle strength training (IMST) is a time-efficient (\~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
Rabbit Antithymocyte Globulin (rATG) /Velcade 1.5mg/kg per dose x 5 doses of rATG. 1.3mg/m2 per dose x 4 doses of velcade. rATG was administered on post-op day 0, 2, 4, and 6. Velcade was administered on post-op day 0, 3, 7 and 10.
Hyperreflexia associated with spasticity is a prevalent neurological condition characterized by excessive and exaggerated reflex responses to stimuli. Hyperreflexia can be caused by several diseases including multiple sclerosis, stroke and spinal cord injury (SCI). Although we have previously identified the contribution of the RAC1-PAK1 pathway underlying spinal hyperreflexia with SCI-induced spasticity, a feasible druggable target has not been validated. To assess the utility of targeting PAK1 to attenuate H-reflex hyperexcitability, we administered Romidepsin, a clinically available PAK1 inhibitor, in Thy1-YFP reporter mice. We performed longitudinal EMG studies with a study design that allowed us to assess pathological H-reflex changes and drug intervention effects over time, before and after contusive SCI. As expected, our results show a significant loss of rate-dependent depression - an indication of hyperreflexia and spasticity - 1 month following SCI as compared with baseline, uninjured controls (or before injury). Romidepsin treatment reduced signs of hyperreflexia in comparison with control cohorts and in pre- and post-drug intervention in SCI animals. Neuroanatomical study further confirmed drug response, as romidepsin treatment also reduced the presence of SCI-induced dendritic spine dysgenesis on α-motor neurons. Taken together, our findings extend previous work demonstrating the utility of targeting PAK1 activity in SCI-induced spasticity and support the novel use of romidepsin as an effective tool for managing spasticity. KEY POINTS: PAK1 plays a role in contributing to the development of spinal cord injury (SCI)-induced spasticity by contributing to dendritic spine dysgenesis. In this study, we explored the preclinical utility of inhibiting PAK1 to reduce spasticity and dendritic spine dysgenesis in an SCI mouse model. Romidepsin is a PAK1 inhibitor approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma. Here we show that romidepsin treatment after SCI reduced SCI-induced H-reflex hyperexcitability and abnormal α-motor neuron spine morphology. This study provides compelling evidence that romidepsin may be a promising therapeutic approach for attenuating SCI-induced spasticity.
PURPOSE: A composition containing an Ecklonia cava extract or phloroglucinol isolated from the extract is provided to suppress DNA damages and nerve cell injuries and to prevent or treat Parkinson's disease. CONSTITUTION: A composition for preventing or treating Parkinson's disease contains an Ecklonia cava extract as an active ingredient. The extract is prepared using water or an organic solvent. The extract contains phloroglucinol. The composition for preventing or treating Parkinson's disease contains phloroglucinol as an active ingredient. The Ecklonia cava extract or phloroglucinol suppresses or prevents nerve cell injury caused by 6 -hydroxydopamine(6-OHDA).
PROBLEM TO BE SOLVED: To provide a method of configuring and monitoring system units in a medical diagnostic system and those equipment. SOLUTION: The method of configuring and monitoring system units in a medical diagnostic system is as follows: Telecommunications are established between a medical diagnostic system (100) and a facility (1022) located in a remote area. Characteristic information on a task for a system unit (110) in the medical diagnostic system is transmitted from the facility located in a remote area to the medical diagnostic system. Configuration of the medical diagnostic system is performed depending on the characteristic information on the task for the system unit. The medical diagnostic system monitors information on the task performed by the system unit in the medical diagnostic system, using an operator workstation.  Equipment is provided with a storage medium (123), which stores information on the system units in the medical diagnostic system by connecting the system units and the storage medium and a communication interface (1048), which enables communications between the medical diagnostic system and the facility in a remote area.
The invention relates to a method for extracting bioactive ingredients from chrysanthemum and preparing dry extract of chrysanthemum. The method extracts bioactive ingredients from chrysanthemum by an extracting method of alcohol hot reflux; recycling extraction-concentration technique of solvent is adopted; and dry extract of chrysanthemum is obtained by spraying and drying. By the technique, the main active ingredients of the dry extract of chrysanthemum are bioactive substances of flavonoid compounds, amino acid, chlorogenic acid and trace elements and the like. Due to the recycling extraction technique of the solvent is adopted, the invention improves extraction rate of the active ingredients, reduces usage of solvent, utilizes vacuum technology to reduce energy consumption, recycles organic solvent, saves energy, reduces environmental pollution and reduces production cost. The spray drying technology is a method for using fluidization technique for drying liquid materials; and due to instantaneous drying, the damage to materials is little, and the obtained product has good quality. The dry extract of chrysanthemum can be prepared into particles by tabletting, filling capsule or drying method and has wide market prospect.
Plant-based meat alternatives that closely emulate animal protein provide a new opportunity to decrease meat consumption worldwide. Decreasing meat consumption and shifting to a plant-based diet has been linked to improvements in physical health, including decreased risk of cardiovascular disease, metabolic syndrome, and type 2 diabetes (Kahleova, Levin, \& Barnard, 2017). However, the extent to which plant-based meat alternatives specifically can modulate biomarkers of physical health, particularly TMAO and IGF-1, and the gut microbiome remain relatively unexplored. It is also largely unknown to what extent consumers can feasibly and sustainably exchange meat products for plant-based meat alternatives for extended periods of time. Plant-based meat alternatives offer a promising way to support consumers' shift to a plant-based diet, and in turn, to potentially improve levels of TMAO and IGF-1 and decrease cardiovascular risk. Thus, the investigators hypothesize that consumer levels of TMAO and IGF-1 will be improved after 8 weeks of consuming plant-based meat alternative products, as compared to 8 weeks of consuming traditional meat products.
The paper explores the thoughts and manipulations of tuina at "Tianyou (TE 16) and five regions" for the treatment of acute pharyngitis based on "Tianyou (TE 16) and five regions" in Huangdi Neijing (Yellow Emperor's Inner Classic). "Tianyou (TE 16) and five regions" refer to the special acupoints of yang meridians, mostly located at the neck region. It is the "window" of the head and neck, acting on dispersing wind and regulating qi and blood by opening the "window". Acute pharyngitis is caused by the invasion of exogenous wind and heat to the throat or by re-attack of exogenous factors and heat accumulation in the lung and stomach. Pathogenic wind and heat is the chief causative factor. Based on the theory and location of "Tianyou (TE 16) and five regions", the manipulations of tuina, i.e. point-pressing, plucking and smoothing, are operated to open "huyou" (door and window) of the head and face, combined by bleeding at the ear apex so that the path is opened for pathogen elimination. As a result, the pathogenic wind and heat are dispelled, qi movement is promoted and the throat is benefited.
For oral administration: DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.

The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue DEXAMETHASONE ELIXIR and transfer the patient to other therapy.

After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.

Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.

If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually.

The following milligram equivalents facilitate changing to DEXAMETHASONE ELIXIR from other glucocorticoids:
Experimental condition clinicians will complete the same online training modules for MBC (BOLT) as the control group, but also complete the Virtual Implicit Bias Reduction and Neutralization Training (VIBRANT) module (45 minutes). They will also receive two 1-hour long, live post-training consultation sessions and expert-facilitated asynchronous online discussion board.