anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Sleep is essential in the process of memory consolidation. Children and adolescents with epilepsy hold a significantly higher risk for memory impairment. Understanding the relationship between sleep and memory impairment in adolescents with epilepsy will help us to develop effective support services for this patient population. The present study provides a summary of the current research on the influence of epilepsy-related altered sleep patterns on memory consolidation in children and adolescents with epilepsy. The aim of this systematic review is to investigate the influence of epilepsy-related altered sleep conditions in children and adolescents and their impact on memory performance.
MATERIALS: A systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses using the search terms "memory," "sleep," "epilepsy," "children," and "adolescents." A total of 4 studies met the inclusion criteria. The review focused on the association of sleep disorders and memory performance in children and adolescents aged up to 21 years without psychiatric comorbidities.
RESULTS: The reviewed studies highlight a higher risk of sleep disturbance and lower sleep quality in children with epilepsy in comparison to control groups. Group differences in memory consolidation were found before, but not after one night of sleep. Three studies reported a significant association between sleep and memory performance. Two studies demonstrated an association between nocturnal interictal epileptiform discharges and memory performance in adolescents.
CONCLUSION: Children and adolescents with epilepsy have a higher risk of sleep and memory disorders. Nocturnal interictal epileptiform discharges have been shown to interfere with memory consolidation. Conclusions on underlying mechanisms remain unclear. Further case-control studies addressing sleep and its influence on memory problems in pediatric epilepsy patients are needed.
On day 1, low CHO dinner meal will provide 35% of participants total daily energy requirements. Meal will based on burger, cheese, mushroom, nuts, and butter.On the day 2, participants will exercise fro 60 minutes and then in 60 will consume morning meal, providing 30% of their total daily energy requirements. Meal will consist of white bread, egg, cheese, olive oil, nuts, and olives.
Alzheimer's disease and related dementias (ADRD) are a major cause of mortality and disability in later life and cost the US healthcare system more than cancer or heart disease. The National Alzheimer's Plan Act and the National Institutes of Health have identified ADRD disparities among ethnic minorities as a public health priority. Latinos with ADRD experience substantial disparities with reduced rates of early diagnosis and lower quality care compared to their non-Latino white peers, which put them at an increased risk for steeper cognitive decline, morbidity, mortality and higher caregiver burden. A number of barriers conspire to create these disparities including a lack of an evidence-based strategy to address ADRD in clinics, patient and primary care provider (PCP) reduced ADRD knowledge, negative attitudes regarding ADRD, PCP's lack of time, cultural and language barriers and health insurance status. To improve healthcare delivery to Latinos with ADRD, researchers need to redesign current ADRD detection and care systems to follow evidence-based recommendations for early detection and culturally appropriate chronic care.

The overall aim of this proposal is to enhance the delivery of ADRD services to Latinos in primary care through a scalable systems approach that includes evidence-based recommendations. Primary care clinics are the ideal setting to provide ADRD services, as 93% of older Latinos have a usual source of healthcare. The novel systems approach (Alianza Latina/Latino Alliance) will enhance timely ADRD diagnosis and optimal care to minimize behavioral symptoms and cognitive decline among Latinos in a linguistically and culturally-appropriate way. Alianza Latina will use the Collaborative Care Framework that capitalizes on PCPs and Health Navigators. 1) PCPs will undergo evidence-based training to enhance timely and culturally appropriate diagnosis and implement it in their work routine. 2) PCPs will detect, treat and refer Latino ADRD patients to a bilingual Health Navigator to provide chronic care management, which will reduce PCP time burden.

Aim 2: Test the feasibility and acceptability of Alianza Latina. Aim 2.a: The research team will train PCPs from Kansas City clinics to enhance skills in cultural competence, ADRD detection, treatment and referral to a Health Navigator among Latinos 65 and older with ADRD. Aim 2.b. The Health Navigator will provide patients/caregiver dyads referred by Alianza Latina PCPs with care management, psychosocial support and links to relevant community resources. The research team will assess the feasibility and acceptability of 1) PCP training and 2) patient and caregiver ADRD care. Caregivers will be enrolled in a text messaging program, called CuidaTEXT, that will educate about memory and thinking problems, solve problems that are common among families with memory and thinking problems, send reminders for appointments and medications, and improve communication with the PCP, family, friends, and other resources.
The present invention discloses a sort of polysaccharide biological calcium and a preparation method thereof. If the polysaccharide biological calcium presents in a solid state, the present invention comprises calcium element, polysaccharide and at least 18 kinds of amino acids, wherein the calcium element accounts for 20 to 30 wt% of the total amount of the polysaccharide biological calcium, the polysaccharide accounts for 3 to 8 wt% of the total amount of the polysaccharide biological calcium and the total amount of the amino acids accounts for 6 to 10 wt% of the total amount of the polysaccharide biological calcium. Otherwise, if the polysaccharide biological calcium presents in a liquid state, the present invention comprises the calcium element, the polysaccharide and at least 18 kinds of the amino acids, wherein the calcium element accounts for 1.0 to 1.5 wt% of the total amount of the polysaccharide biological calcium, the polysaccharide accounts for 0.1 to 0.2 wt% of the total amount of the polysaccharide biological calcium, and every 100 milliliters of the polysaccharide biological calcium contains the amino acids with the total amount of 50 to 100 milligrams. The preparation method comprises the steps of the preparation of culture mediums, inoculation and culture, the expanding culture of strains, the mixing of the strains obtained by the expanding culture and culture medium containing calcium carbonate, ph value adjustment and culture and solid-liquid separation. The product not only contains high content of calcium, but also contains large amounts of polysaccharides desired by human bodies, at least 18 kinds of the amino acids, etc. In addition, the present invention also has the advantages of low heavy metal content, good taste, favourable effect of calcium supplement and simplicity and easy mastery of the method.
INTRODUCTION: The ERAS protocol is a set of international guidelines established to expedite patients' discharge after colorectal surgery. It does this by aiming to prevent postoperative complications early, and return the patient to normal function allowing earlier discharge. Complications such as PONV, DVT, ileus and pain are common after surgery to name a few, and delay discharge. Early treatment and prevention of these complications however is suggested to aid a patients' return to home at earlier rates than traditional practice.
METHODS: A prospective chart review and questionnaire was performed on patients undergoing colorectal surgery in UHL in a 6-month period from February to September 2023. Patients were approached on the 3rd day postoperatively and informed about the project. Exclusion criteria included patients who went to HDU or ICU postoperatively.
RESULTS: In total, 33 patients were recruited. A target of greater than 70% compliance was reached for a variety of the elements of the ERAS protocol such as laparoscopic surgery, preoperative assessments, nutritional drinks, LMWH, oral intake within 24 h of surgery, and intraoperative antiemetics. Unsatisfactory compliance was found with documentation of postoperative antibiotics use of preoperative gabapentin.
CONCLUSION: UHL has a satisfactory compliance of over 70% with a large variety of elements of the ERAS protocol. Areas of improvement required include postoperative antibiotic and preoperative gabapentin usage. With the collective effort of the multidisciplinary team, along with education, the ERAS protocol can successfully be applied and implemented in a model 4 hospital in Ireland.
Patients receive standard of care chemotherapy for up to 3 courses and simvastatin (PO) daily 2 days before the first dose of chemotherapy for up to 2 days after the last dose of chemotherapy. Treatment with simvastatin continues in the absence of disease progression or unacceptable toxicity.
Embryo evaluation and selection is fundamental in clinical IVF in order to obtain a live birth in a shorter delay as possible, but minimizing the risk of multiple pregnancies. TLT was introduced few years ago in clinical practice and allows the continuous follow up of the embryo development. In IVF centers, embryos are preferentially cultured in TL system with undisturbed environmental conditions. This provides information about the development of the embryos in time intervals of 15min and adds kinetic criteria for embryo evaluation and selection. In conventional incubator, the follow up of embryo development consists in 3 static time point observations. Many reviews and observational studies have discussed the value of time-lapse monitoring but it is as yet unclear, however, whether the TLT improves the results of IVF. It has been suggested that the clinical benefits of applying new technologies should be verified and documented by randomized controlled trials. Moreover, the cumulative live birth rate and the delay for conception were rarely reported. The study aims to evaluate the results of the first IVF attempts comparing classical embryo culture in standard incubator and embryo culture and follow up in TLT. The hypothesis is that the undisturbed culture and the selection based on continuous time-lapse images improve the results of the single embryo fresh transfer and increase the cumulative live birth rate. Patients will be randomized the day of the puncture for the type of culture: standard incubation or TLT. The results of the fresh and successive vitrified-warmed embryo transfer will be prospectively collect and patients will be followed until live birth. The attempt will be considered ended after a live birth, if all the frozen embryos are transferred, after 24 months follow up or after surrender.
Use of equilibrating agents in the fertilisation of mammals in order to improve reproduction is new. The equilibrating agents contain effective amounts of (a) those components absent from the genital tract secretions of oestrous but infertile females but present in the genital tract secretions of oestrous and fertile animals in the same locality and/or (b) substances which tender inactive components present in excess in the genital tract secretions of estrous but infertile animals. The method is based on the finding that the genital tract secretions of oestrous but infertile animals differ in composition from the genital tract secretions of oestrous and fertile animals, showing in particular a deficiency in enzyme activators and/or substrates and an excess of calcium and/or magnesium ions. As enzyme-activating agents, the equilibrating agents pref. contain zinc, selenium, copper, iodine, iron and/or cobalt ions. As enzyme substrates, the agents pref. contain fats or fat-like substances, carbohydrates or proteins. As components to bind excess calcium and/or magnesium ions, the agents pref. contain chelating agents, esp. polyaminocarboxylic acids or their salts. Process is used for improving the success rate of artificial insemination of animals under conditions of intensive rearing.
The purpose of the present invention is to provide an acetate compound in which acetic acid odor can be reduced and decomposition of glucose can be suppressed even when the acetate compound is made to coexist with glucose. This compound is a higher-order acetate compound containing acetic acid-sodium acetate mixed crystals, wherein a diffraction peak A at 2?=8.8??0.2? and a diffraction peak B at 2?=22.3??0.2? are observed in a powder X-ray diffraction measurement, and the ratio Ia/Ib of the integrated intensity Ia of the diffraction peak A to the integrated intensity Ib of the diffraction peak B is less than 1.447. By using the higher-order acetate compound, volatilization of acetic acid can be effectively suppressed, acetic acid odor can be reduced, and decomposition of glucose can be suppressed even when the acetate compound is made to coexist with glucose. (Most illustrative figure: FIG. 1)
Participants will be evaluated with the "Postural Stability Test", "Limits of Stability Test", "Sensory Integration Test" and "Bilateral Comparison Test" within the AlBalance Balance Evaluation System. To calculate the test-retest reliability of the device, these measurements will be made by the same evaluator, will last 30 seconds and will be repeated a total of 3 times with a 1-minute rest between tests. These measurements will be repeated after 7 days to evaluate reliability. Then, parallel clinical tests will be applied to the participants, "Functional Reaching Test" and "One Leg Standing Test".
<P>PROBLEM TO BE SOLVED: To obtain a water-absorbing polymer particle in which a silicone compound stably exists on the surface of a water-absorbing polymer particle even during mixing and formulating of various preparations and which has excellent spread, provides smooth and light feeling of use and has excellent durability of its feel, to provide a method for producing the same and to obtain a cosmetic containing the water-absorbing polymer particle.  <P>SOLUTION: The silicone-modified water-absorbing polymer particle has the surface of a water-absorbing polymer particle, coated with a silicone compound containing one or more kinds of functional groups by chemical bond and contains a polyvalent metal ion. The silicone-modified water-absorbing polymer particle is obtained by polymerizing a mixture of a monomer component containing a hydrophilic vinyl monomer and a polyvalent metal salt in the presence of a silicone compound containing one or more kinds of functional groups. The method for producing the silicone-modified water-absorbing polymer particle is provided. The cosmetic contains the silicone-modified water-absorbing polymer particle.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The invention relates to a method for extracting and separating chlorogenic acid from chrysanthemum. The method comprises the following steps: after water-removing is performed to a chrysanthemum, the raw material is lixiviated with solvent under the ultrasonic or microwave action, the crude extract of the chlorogenic acid is obtained after through solid-liquid separation, and then the chlorogenic acid pure product is obtained after through resin adsorption, separation and elution. The solvent is water, organic solvent or organic solvent-water mixed liquor. The water-removing is performed to the chrysanthemum, and the chrysanthemum is lixiviated with organic solvent or water at assistance of ultrasonic sound and microwave. Therefore, the yield of the chlorogenic acid can be improved, the production cycle is reduced, the chlorogenic acid pure product is obtained not the mixture with other ingredients, and the chlorogenic acid monomer is extracted form one chrysanthemum. Therefore, the range of the raw material of the chlorogenic acid can be extended, especially for the chrysanthemum in Canada, the chrysanthemum can turn the harmful into the beneficial and waste into valuable after development and utilization, and the invention has good economic, social and environmental benefits.
A system and method for providing recommendations to a user is disclosed. The recommendations are provided based on condition of health of the user. More specifically, the system analyses vital signs of the user to determine irregularities. If an irregularity is detected, then the system retrieves a health record of the user from a memory of the system. Further, based on the irregularity and the information in the health record, the system determines a condition of health of the user. Further, determines a treatment method for the condition of health, based on information associated with other users subscribed to the system. The treatment method may be either traditional treatment method or modern treatment method. In addition, the system also recommends a caregiver to the user based on the treatment method determined.
Nociceptor cell bodies generate "spontaneous" discharge that can promote ongoing pain in persistent pain conditions. Little is known about the underlying mechanisms. Recordings from nociceptor cell bodies (somata) dissociated from rodent and human dorsal root ganglia have shown that previous pain in vivo is associated with low-frequency discharge controlled by irregular depolarizing spontaneous fluctuations of membrane potential (DSFs), likely produced by transient inward currents across the somal input resistance. Using mouse nociceptors, we show that DSFs are associated with high somal input resistance over a wide range of membrane potentials, including depolarized levels where DSFs approach action potential (AP) threshold. Input resistance and both the amplitude and frequency of DSFs were increased in neurons exhibiting spontaneous activity. Ion substitution experiments indicated that the depolarizing phase of DSFs is generated by spontaneous opening of channels permeable to Na + or Ca 2+ and that Ca 2+ -permeable channels are especially important for larger DSFs. Partial reduction of the amplitude or frequency of DSFs by perfusion of pharmacological inhibitors indicated small but significant contributions from Nav1.7, Nav1.8, TRPV1, TRPA1, TRPM4, and N-type Ca 2+ channels. Less specific blockers suggested a contribution from NALCN channels, and global knockout suggested a role for Nav1.9. The combination of high somal input resistance plus background activity of diverse ion channels permeable to Na + or Ca 2+ produces DSFs that are poised to reach AP threshold if resting membrane potential depolarizes, AP threshold decreases, or DSFs become enhanced-all of which can occur under painful neuropathic and inflammatory conditions.
1.
    Very rare cases of hyponatremia have been reported from world-wide postmarketing experience in patients treated with desmopressin acetate. Desmopressin acetate is a potent antidiuretic which, when administered, may lead to water intoxication and/or hyponatremia. Unless properly diagnosed and treated hyponatremia can be fatal. Therefore, fluid restriction is recommended and should be discussed with the patient and/or guardian. Careful medical supervision is required.
2.
    When desmopressin acetate tablets are administered, in particular in pediatric and geriatric patients, fluid intake should be adjusted downward to decrease the potential occurrence of water intoxication and hyponatremia (see PRECAUTIONS, Pediatric Use and Geriatric Use). All patients receiving desmopressin acetate therapy should be observed for the following signs of symptoms associated with hyponatremia: headache, nausea/vomiting, decreased serum sodium, weight gain, restlessness, fatigue, lethargy, disorientation, depressed reflexes, loss of appetite, irritability, muscle weakness, muscle spasms or cramps and abnormal mental status such as hallucinations, decreased consciousness and confusion. Severe symptoms may include one or a combination of the following: seizure, coma and/or respiratory arrest. Particular attention should be paid to the possibility of the rare occurrence of an extreme decrease in plasma osmolality that may result in seizures which could lead to coma.
3.
    Desmopressin acetate should be used with caution in patients with habitual or psychogenic polydipsia who may be more likely to drink excessive amounts of water, putting them at greater risk of hyponatremia.
INTRODUCTION: Conventional postoperative pain management, with an intravenous patient-controlled approach or thoracic epidural analgesia, has proved suboptimal following a minimally invasive repair of pectus excavatum. Considering its postulated mechanism of action, we encouraged cryoanalgesia as an effective method for postrepair pain management and a possibly superior alternative.
METHODS: A randomized, single-blind clinical trial was tested on patients undergoing pectus excavatum (PE) repair in March and December 2022. Among 101 patients, consenting study participants were randomly assigned to one of two groups: cryoanalgesia (group C, n = 24) or noncryoanalgesia (group N, n = 24). Group N received conventional pain management. Comparing the results, pain levels were measured using the visual analog scale (VAS-R for resting and VAS-D for dynamic) and the total rescue analgesic consumption was determined. Intrathoracic cryoablation was performed bilaterally on the fourth and seventh intercostal nerves using a cryoprobe at -80°C for 2 minutes.
RESULTS: The two groups had similar baseline-patient characteristics; however, group C had a longer mean operative time (159 vs. 125 minutes, p < 0.01) and experienced significantly less pain throughout the postoperative course, with VAS at 6 hours (5.38 vs. 7.04, p < 0.01) and 48 hours (3.17 vs. 5.67, p < 0.01).
CONCLUSION: Cryoanalgesia improved postoperative pain control at rest and during movement following PE repair. However, the outcome was less favorable than expected because the VAS was greater than 4 (moderate pain), although after a day or two, it decreased to lower levels (VAS < 4) in the cyro group. Considering its extra invasiveness and instrumentation, a routine cryoanalgesia procedure for pectus surgery is yet to be determined.
Enalaprilat injection, USP is a sterile aqueous solution for intravenous administration. Enalaprilat is an angiotensin converting enzyme inhibitor. It is chemically described as (S)-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline dihydrate. Its empirical formula is C18H24N2O5•2H2O and its structural formula is:

Enalaprilat is a white to off-white, crystalline powder with a molecular weight of 384.42. It is sparingly soluble in methanol and slightly soluble in water.

Each milliliter of enalaprilat injection, USP contains 1.25 mg enalaprilat (anhydrous equivalent); sodium chloride to adjust tonicity; sodium hydroxide to adjust pH; water for injection, q.s.; with benzyl alcohol, 9 mg, added as a preservative.