anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the field of pharmacology and pharmaceutics, and relates to a fat composition used for injection, a preparing method thereof and uses of the fat composition. A product of the fat composition is good in fluidity and free of wall hanging, has a single-phase, transparent, clear and bright appearance, can be subjected to clarity detection, and is free of preparation layering phenomena after the product is repeatedly frozen and thawed. In a process of forming a fat emulsion system when the product encounters water, homogenization treatment is not needed, and spontaneous emulsification can occur only by slight oscillation. During clinical using, the product can spontaneously emulsify to form the fat emulsion system meeting injection requirements after the product is diluted with normal saline or a glucose solution, and other aqueous solutions and is slightly oscillated. In preferred conditions, after emulsion, the average particle size is 0.1-0.4 [mu]m, distribution of the particle size is narrow and small, and the d(0.9) is smaller than 0.6 [mu]m, thus meeting requirements on particle size distribution of fat emulsion particles used for injection. A preparation process is simple. Only a common physical stirring step is needed, and a homogenizing step or a water removing step is not needed. A prepared lipid emulsion concentrate liquid can be sterilized by passing through a microporous filtration membrane having a size of 0.22 [mu]m. The fat composition, the preparing method and the uses have advantages of simple preparation process, low production cost, and easy transportation and storage, and have a good application prospect.
7-Substd. benzofurans with 1,4-dihydro pyridinic structure of formula (I), for pharmaceutical use as hypotensive agents, are made by (a) reacting one equiv. of 7-benzofuran carbaldehyde with an amt. of the corresp. aceto-acetate, using catalytic amts. of piperidine and glacial acetic acid, in aromatic solvent under reflux (b) reacting with an equimolar amt. of the relevant beta-amino crotonate in non-alcoholic solvent under reflux for 10-30 hours to give (I).
The invention provides a Dai food capable of promoting uric acid metabolism and a preparation method thereof. The Dai food is composed of the following components in parts by weight: 50 to 100 parts of ampelopsis grossedentata leaf, 50 to 100 parts of root of kudzu vine, 60 to 100 parts of grosvenor momordica fruit, 20 to 30 parts of orange peel, 50 to 90 parts of purslane, 50 to 90 parts of mulberry fruit, 30 to 80 parts of lophatherum gracile, 30 to 90 parts of corn silk, 30 to 80 parts of cape jasmine, and 50 to 80 parts of radix astragali. The provided Dai food can reduce the uric acid, and is suitable for the people with high uric acid, gout patients and normal people. By drinking the Dai food, the uric acid can be reduced, the kidney can be targeted and protected; after regular application of the Dai food, the kidney can be strengthened, the uric acid is discharged, and the relapse of high uric acid symptom is inhibited. The Dai food is prepared from natural herbals, and does not any side or toxic effect, people do not need to avoid certain food, the active components in the Dai food can eliminate the toxin in the kidney, the taste of the Dai food is good, the Dai food can be drunk regularly and can meet the modern life requirements. Compared with similar products, the provided Dai food has the advantages of low cost, easy absorption, safety, reliability, no adverse reaction, and no sugar, and is suitable for any people.
OBJECTIVE: To explore the experience of patients with incontinence and incontinence-associated dermatitis (IAD) in acute care hospitals and their family caregivers, including their perceptions and management, as well as the impact on their wellbeing.
METHOD: A qualitative exploratory study design was employed in 18 wards across six acute/subacute hospitals in New South Wales, Australia. Patients with incontinence (with or without IAD) were invited to participate. Where interviews were not possible with the patient, their family caregiver was invited to participate. Semi-structured interviews were conducted.
RESULTS: There were 45 interviewees in the study; 41 were patients with incontinence (11 of whom had IAD) and four were family caregivers. The experience of incontinence was captured by three themes: 'incontinence interrupts every aspect of my life'; 'actively concealing and cloaking'; and 'perceived as irreversible'. Incontinence was expected by the patients at their age and did not come as a surprise. It was normalised and approached with stoicism. As such, patients self-managed their incontinence by developing strategies to ensure they avoided episodes of incontinence during their stay. Incontinence left patients feeling anxious, embarrassed and with a sense of shame, and they did not communicate these feelings, or engage with health professionals about their incontinence, nor did health professionals discuss their incontinence with them. There was a strong sense of resignation that incontinence was irreversible and nothing could be done to improve it. All participants displayed little knowledge of IAD. The experience of having IAD was characterised by the theme 'debilitating and desperate for relief' and was experienced as a particularly painful, itching and burning condition that left patients distressed and irritable.
CONCLUSION: Patients with incontinence in acute settings required further education from health professionals to reduce the stigma of incontinence, and provide further support to manage their incontinence. Health professionals can also play a key role in educating patients about the risks of developing IAD and how it can be prevented.
Hyperlactatemia is common during tumor craniotomy, but the underlying pathophysiology is unclear. This study measured simultaneous arterial and jugular-bulb lactate concentrations in patients undergoing brain tumor craniotomy to investigate the hypothesis that hyperlactatemia was associated with a net cerebrovascular lactate input. In 20 patients, arterial and jugular-bulb blood was collected hourly from the start of surgery to 6 h postoperatively for measurement of lactate, glucose, and oxygen concentration. For each marker, data were analyzed using a linear mixed-effects model with jugular-bulb concentration as dependent variable, arterial concentration as fixed effect, and patient as random effect. Furthermore, we generated regression lines between arterial and jugular-bulb concentrations. The slope of the regression line between arterial and jugular-bulb lactate was 0.95 (95% CI 0.93-0.97, R2 = 0.98), indicating that increasing arterial lactate levels were associated with an increasingly positive net cerebrovascular balance (net input). The line crossed the identity line at 2.86 (95% CI 0.57-5.16) mmol/L, indicating that lower levels of lactate were associated with a negative net cerebrovascular balance (net output). This suggests a switch from net lactate output during normolactatemia towards net input during hyperlactatemia. Hyperlactatemia in tumor-craniotomy patients probably does not originate from the brain.
Current technologies to treat end stage renal disease (ESRD) include peritoneal dialysis, hemodialysis and transplantation all of which are expensive. This invention is an inexpensive method to decrease body toxins that requires immersion of a body in a hot water bath with sorbents. In a hot water bath, secretory coils within activated sweat glands function as a semipermeable membrane that can dialyze toxins. Sorbents such charcoals and smectite clays located within the secretory coils of sweat glands in the vicinity of the zonula occludens can adsorb toxins. A subject who was immersed in a hot water bath with dissolved activated charcoal for a total time of approximately two hours presumably developed heparin deficiency from the adsorption of heparin onto activated charcoal. This invention is not expected to replace hemodialysis or peritoneal dialysis for the treatment of ESRD, but it may delay the initiation of traditional dialysis, decrease the number of high cost traditional dialysis procedures and improve quality of life. Patients who do not suffer from ESRD but who claim wellbeing from periodic detoxification may benefit from this invention. However, caution needs to exercised that unmonitored indiscriminate adsorption from hot water sorbent baths pose some dangers.
PURPOSE:To obtain a trichogenous and gray hair blackening agent, composed of an extract solution prepared from Eugenia caryophyllata THUNBERG or Decaspermum fruticosum FORST or a solution prepared by steam distillation thereof and having excellent trichogenous and hair growing action without damaging the skin. CONSTITUTION:Flower buds of Eugenia caryophyllata THUNBERG or young leaves or spikes of Decaspermum fruticosum FORST are macerated with an organic solvent such as ethyl alcohol and filtered to provide an extract solution or such an extract solution is then subjected to steam distillation to afford en essential oil, which is subsequently dissolved in an organic solvent (e.g. ethyl alcohol) so as to afford 0.2-1.5% concentration. Thereby, a solution is obtained. The resultant extract or the solution is then suitably blended with female hormones, an (ethylenedinitrilo)tetraacetate, pantothenyl alcohol, vitamin E, a perfume, etc., and prepared to afford the objective substance. The resultant agent is preferably used by sprinkling the agent in a volume of 1-3ml at a time over the scalp 1-2 times a day and lightly massaging the scalp with fingertips.
Elevated blood glucose levels constitute a major risk factor for pre-diabetic and diabetic patients. Postprandial glucose tests have been used for decades to monitor and compare glucose responses. Yet, individuals eating identical meals present high variability in post-meal blood glucose response making comparisons challenging. A recent landmark study showed that the inter-individual variation of postprandial glucose responses was associated with multiple person-specific factors including faecal microbiome factors. Gut microbial richness has for a long time been considered a hallmark of gut health and stability. Furthermore, microbial richness has been associated with colonic transit time, which together with the gastric emptying rate appear to be major determinants of the initial glycaemic response to carbohydrate-containing meals. Therefore, the aim of the study is to investigate whether postprandial glucose responses are associated with gut microbial richness, as well as secondary measures including gastric emptying rate, intestinal transit time and gut microbial composition and fermentation.

In an acute-meal study, 40 healthy fasted participants will consume a standardized breakfast including one tablet of paracetamol (for estimating gastric emptying rate) and 300 mL of juice.
The RNA study is an observational trial whose primary aim is to document the performance (sensitivity and specificity) of one or more laboratory developed test (LDT) using circulating cell-free fetal nucleic acids from maternal plasma to identify Down syndrome. Multiple test modalities are being pursued, including massively parallel sequencing and those utilizing differential methylation. The population being studied is women already having a diagnostic test (e.g., amniocentesis, CVS) between 10 weeks and 21 weeks 6 days gestation, and whose pregnancy is at high risk for having Down syndrome. The women provide informed consent. The karyotype will provide the gold standard against which the LDT test is judged. Samples and karyotypes will be collected from up to 25 prenatal diagnostic centers around the world and tested in several laboratories in the United States. The secondary aim is to develop a nucleic acid sample bank to allow documentation of subsequent improvements or new methodologies to identify fetal aneuploidy using circulating cell-free fetal nucleic acids.
In order to determine the exercise capacity of subjects, submaximal exercise test will be performed.Aerobic training will be done 3 days a week for 12 weeks. Subjects will be followed for 24 weeks.
The present invention provides a novel process for preparing bioartificial hydrogels. This process comprises mixing a bifunctionalized polymer and a protein derived from a vegeral source or milk in an aqueous solution under basic conditions to form a three-dimensional reticulated mixture or gel. Specifically, the novel hydrogels are based on the cross-linking of a protein derived from milk or from a vegetal source (such as casein, hydrolyzed soy protein or hydrolyzed wheat protein) with a biofunctionalized polymer, such as polyethylene glycol or oxide. Preferably, the bifunctionalized polymer is polyethylene glycol. The invention further comprises the hydrogels produced by the novel process and a plurality of biomedical applications based on these hydrogels. These novel hydrogels possess advantageous characteristics, such as shape retention, shape memory, high water content (greater than 95 % (w/w) based on the dry weight of the hydrogel), and good mechanical and optical properties. The hydrogels exhibit additional characteristics -- biocompatibility, controlled release of medications or drugs, hydrophilic surface, oxygen permeability, and controlled porosity -- that should make them highly suitable for pharmaceutical, medical and cosmeceutical applications.
Individuals were divided into two groups: type 2 diabetes and control. Individuals with type 2 diabetes were followed for 12 weeks with an appropriate diet specific to their condition, and necessary measurements were taken at the beginning, 4th week, and 12th week. No dietary intervention was made for the control group, and necessary measurements were taken at the beginning and 12th week. At the control points, biochemical parameters, serum samples, anthropometric measurements (body composition, weight, height, waist circumference, hip circumference), 24-hour dietary intake record, and 24-hour physical activity record were evaluated. In the experimental group, dietary intake was recorded at the beginning (week 0), 4th week, and 12th week. The dietary intake of the control group was examined at week 0 and week 12.

The "Phytochemical Index" method was used to calculate the total phytochemical intake from the diet. The total antioxidant capacity of the diet was calculated using data obtained from dietary intake records based on Ferric Reducing Ability of Plasma (FRAP), Oxygen Radical Absorbance Capacity (ORAC), Trolox Equivalent Antioxidant Capacity (TEAC), and Total Reactive Antioxidant Potential (TRAP) methods. Additionally, physical activity was determined using a recording method. Body compositions at all three control points will be determined using the bioelectrical impedance method, and waist and hip circumference measurements were taken using a non-stretchable tape measure. Routine biochemical parameters for the type 2 diabetic group (fasting blood glucose, serum lipids, HbA1c) were obtained from the records. Serum samples collected after a 10-12 hour fasting period at the beginning and 12th week were analyzed for Fibroblast growth factor 21 (FGF21) using suitable kits.
A sugar free tooth "n" gum chewing gum (FIG 1, not shown) has been impregnated with an effective concentration of magnesium trisilicate which neutralises plaque and food acids, and acts as a tooth polish during the chewing action. A number of further components may be added to the sugar free chewing gum. For example, the addition of calcium pyrophosphate provides an effective agent against plaque and tartar; the addition of an anti-bacterial artificial sweetener, such as xylitol, improves the anti-plaque action and eliminates the sugar substrate that plaque bacteria feed on. Extra artificial sweeteners like sorbitol, improve flavour. Other additives may include cetylpyridinium chloride, which is an anti-bacterial and mouth ulcer treatment, breath fresheners and different flavours to enhance the appeal of the product. Each stick of chewing gum may be hygienically wrapped in its own foil and paper wrapping and these may in turn be sold in plastic wrapped multi packs.
AIMS: (a) To investigate support for caregivers of people diagnosed with stroke, cancer, chronic obstructive pulmonary disease (COPD), dementia, or heart disease provided across healthcare settings in Denmark; (b) to assess differences in caregiver support across diagnoses and settings.
METHODS: A cross-sectional nationwide survey among professionals representing healthcare settings at municipalities (n = 479) and hospital wards and outpatient clinics (n = 425). The survey assessed identification of caregivers and support initiatives.
RESULTS: The response rate was 81% for municipalities and 49% for hospitals. Identification of caregivers was frequent in dementia care (81% and 100%) and less frequent in COPD care (58% and 64%) in municipalities and hospitals, respectively. Caregiver support differed significantly across diagnoses within municipalities (p = 0.009) and hospitals (p < 0.001). Systematic identification of vulnerable caregivers was <25% for all diagnoses except dementia. The most common support initiatives involving caregivers were primarily aimed at the ill person and included guidance about the disease and consequences for everyday life and lifestyle changes. Caregivers were least involved in support initiatives addressing physical training, work retention, sexuality, or cohabitation.
CONCLUSIONS: Disparities and significant differences across diagnoses exist in the identification of caregivers and the provision of support initiatives. Support initiatives involving caregivers primarily targeted patients. Future studies should investigate how caregivers' needs can be met across different diagnoses and healthcare settings and investigate potential changes in caregivers' needs during disease trajectories. In clinical practice, identification of vulnerable caregivers should be a major focus, and disease-specific clinical guidelines may be required to ensure sufficient support for caregivers.
Designing a personalized implant to restore the protective and aesthetic functions of the patient's skull is challenging. The skull defects may be caused by trauma, congenital malformation, infection, and iatrogenic treatments such as decompressive craniectomy, plastic surgery, and tumor resection. The project aims to develop a deep learning system with 3D shape reconstruction capabilities. The system will meet the requirement of designing high-resolution 3D implant numerical models efficiently.

A collection of skull images were used for training the deep learning system. Defective models in the datasets were created by numerically masking areas of intact 3D skull models. The final implant design should be verified by neurosurgeons using 3D printed models.
Intermediate dose anticoagulation will be the the tested regimen. The anticoagulation regimen will be modified according to weight/ body mass index, and creatinine clearance level (Cl Cr). Enoxaparin will be the primary agent for anticoagulation, with unfractionated heparin reserved only for patients with creatinine clearance of ≤15 mL/min according to Cockcroft-Gault Formula.
Several studies show a significant drop in pain scores, improved fertility outcomes and amelioration of impaired sexual functioning in women following surgical resection of colorectal endometriosis. However, there is inceasing evidence that intermediate and long-term bowel dysfunction may occur as a consequence of radical surgery for rectal deep endometriosis (DE). Typical symptoms include constipation, feeling of incomplete evacuation, clustering of stools and urgency. This is described in the colorectal surgical literature as low anterior resection syndrome (LARS). The choice of operation is largely dependent on the extent of disease. Statistically significant differences in functional outcomes were found in favor of the conservative surgical approach, i.e. resection of endometriotic tissue with preservation of the luminal structure of the rectal wall thereby avoiding segmental bowel resection. In a recent retrospective multicentric cohort analysis, the incidence of LARS after either nerve and vessel sparing segmental resection (NVSSR) or transanal disc excision (TADE) performed for the surgical treatment of colorectal DE was assessed. All patients underwent a low rectum resection, with a resection line lower than 7cm from anal verge. In contrast to previoisly published data, no statistically significant difference between the incidence of the LARS among patients operated using TADE when compared to women treated by NVSSR were found. Interestingly, the occurence of LARS was positively associated with the use of protective ileo-or colostomy. A higher rate of severe complications was observed in the TADE group than among patients who underwent a NVSSR. Weaknesses of this study are the retrospective design and a possible bias in the TADE regarding larger DE nodules as well as the possibility of bowel dysfunction prior to surgery in women with DE.

The primary aim of the present study is the prospective comparison of two surgical approaches for full thickness excision of rectal DE resulting in an anastomotic height ≤7 cm distance from the anal verge. One technique involves the preservation of the residual luminal wall integrity (disc resection) known as Rouen technique/ TADE. The other technique involves limited resection of the bowel wall with preservation of all adjacent structures (autonomic pelvic plexus, rectal vascular supply) known as NVSSR. Gastrointestinal functional outcomes of the two procedures will be compared using the LARS / GIQLI by Eypasch questionnaires. Since digestive complaints may also be present presurgically, evaluation of digestive complaints will be recorded pre- and post surgery.
The invention discloses a traditional Chinese medicine composite and ointment capable of strengthening acupunture therapeutic effects and a preparation method thereof. The method belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composite capable of strengthening acupunture therapeutic effects comprises, by weight, 16-20 parts of cassia twigs, 16-20 parts of fructus liquidambaris, 11-14 parts of ginger, 11-14 parts of fructus chaenomelis, 7-9 parts of fructus foeniculi, 3-5 parts of evodia rutaecarpa, 11-14 parts of folium artemisiae argyi, 27-32 parts of lignum millettiae, 11-14 parts of ligusticum wallichii, 11-14 parts of rhizoma corydalis, 11-14 parts of fraxinus bungeana and 7-9 parts of liquorice. The fragrant components in the Chinese medicine can stimulate the local vasodilatation, speed up the blood flow. The medicine is beneficial to the permeation and absorption of medicines. The medicine can trigger subcutaneous vascular dilation and speed up blood flow, can increase histioblast membrane permeability, improve histotrophic metabolism, promote tissue regeneration, create warm feelings, strengthening acupunture therapeutic effects. The medicine has no toxic and side effects, causes no pain to patients. The healing effects are good. The cost is low. The medicine has the functions of warming and channeling blood veins, promoting blood circulation of wandering arthritis patients and is a big creation in the field of acupunture therapeutic effects strengthening medicine.