PATIENT INFORMATION Glucagon (GLOO-ka-gon) for injection, for subcutaneous, intramuscular or intravenous use What is Glucagon? Glucagon is a prescription medicine used: to treat very low blood sugar (severe hypoglycemia) in people with diabetes. to stop stomach movement (gastrointestinal motility inhibitor) in patients receiving radiology exams. Who should not use Glucagon? Do not use Glucagon if: you have a tumor in the gland on top of your kidneys (adrenal gland) called a pheochromocytoma. you have a tumor in your pancreas called an insulinoma. you are allergic to glucagon or lactose or any of the ingredients in Glucagon. See the end of this Patient Information leaflet for a complete list of ingredients in Glucagon. you have tumors in your pancreas called Glucagonomas because it could cause low blood sugar when used for your radiology exam. What should I tell my doctor before using Glucagon? Before using Glucagon, tell your doctor about all of your medical conditions, including if you: have kidney problems. have pancreas problems. have not had food or water for a long time (prolonged fasting or starvation). have low blood sugar that does not go away (chronic hypoglycemia). have heart problems. are pregnant or plan to become pregnant. It is not known if Glucagon will harm your unborn baby. are breastfeeding or plan to breastfeed. It is not known if Glucagon passes into your breast milk. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Glucagon may affect the way other medicines work, and other medicines may affect how Glucagon works. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine. How should I use Glucagon? Read the detailed Instructions for Use that come with Glucagon. Use Glucagon exactly as your doctor tells you to. Make sure that you and your family know how to use Glucagon the right way before you need it. Act quickly. Having very low blood sugar for a period of time may be harmful. Call for emergency medical help right after you use Glucagon. If the person does not respond after 15 minutes, another dose may be given, if available. Eat sugar or a sugar sweetened product such as a regular soft drink or fruit juice as soon as you are able to swallow. Tell your doctor each time you use Glucagon. Your doctor may need to change the dose of your diabetes medicines. What are the possible side effects of Glucagon? Glucagon may cause serious side effects, including: High blood pressure. Glucagon can cause high blood pressure in certain people with tumors in their adrenal glands. Low blood sugar. Glucagon can cause low blood sugar in patients with tumors in their pancreas called insulinomas and Glucagonomas by making too much insulin in their bodies. Serious allergic reactions. Call your doctor or get medical help right away if you have a serious allergic reaction including: rash difficulty breathing low blood pressure High blood sugar. If you receive Glucagon before your radiology exam it can cause high blood sugar. Your doctor will monitor your blood sugar levels during your treatment. Heart problems. If you have heart problems and receive Glucagon before your radiology exam, you may have an increase in your blood pressure and pulse while using Glucagon which could be life threatening.Your doctor will monitor your heart during treatment. The most common side effects of Glucagon include: swelling at the injection site redness at the injection site vomiting nausea decreased blood pressure weakness headache dizziness pale skin diarrhea sleepiness or drowsiness Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Glucagon. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. How should I store Glucagon? Before you mix the Glucagon powder and liquid: Store Glucagon at room temperature between 68°F to 77°F (20°C to 25°C) for up to 24 months (2 years). Do not freeze Glucagon. Keep Glucagon in its original package Glucagon and out of light. After you mix the Glucagon powder and liquid: Use Glucagon right away. Throw away any unused Glucagon. Glucagon should be clear and colorless. Do not use Glucagon if it is cloudy or if you see particles in the solution. Keep Glucagon and all medicines out of the reach of children. General information about the safe and effective use of Glucagon: Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Glucagon for a condition for which it was not prescribed. Do not give Glucagon to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Glucagon that is written for health professionals. What are the ingredients in the Glucagon? Active Ingredient: Glucagon Inactive ingredients: lactose monohydrate and sterile water for reconstitution For more information, go to www.fresenius-kabi.com/us or call 1-800-551-7176.

This Patient Information has been approved by the U.S. Food and Drug Administration

Approved: 09/2019