anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Tennis is a sport characterized by coordinated, repetitive, and powerful movements along the kinetic chain. Being both overhead and rotational, achieving a good shot in tennis involves transferring high forces and energy from the lower extremities to the upper extremities through the trunk. In this context, core muscles play a crucial role in athletic performance by stabilizing the shoulder girdle, pelvis, and spine, acting as a pivot point for extremity movements. Therefore, good core strength is essential during a stroke. Additionally, as the acceleration of the ball is influenced by both maximum external and internal rotation of the shoulder, tennis players require good shoulder mobility and stability. In this regard, the scapula in the shoulder girdle provides a stable foundation for the glenohumeral mobility necessary for the shot. Both the core and scapular regions serve as pivot points for upper extremity functional activities. Therefore, this study aims to examine the relationship between scapular endurance, core endurance, and upper extremity performance in adolescent tennis players. The hypothesis of this study is that better scapular/core endurance in adolescent tennis players is associated with better upper extremity performance. Establishing this relationship will contribute to identifying the exercise training necessary to improve upper extremity performance in tennis players.
Participants will received cenerimod 4 mg capsules orally once daily for 12 weeks. This treatment arm will start after all patients in Part A have completed 4 weeks of placebo, 0.5 mg, 1 mg and 2 mg cenerimod treatment.
This data resource provides evidence concerning the prevalence of perceptual alterations of emotional faces amongst individuals experiencing symptoms of insomnia, anxiety, depression, mania, psychotic experiences, and schizotypal tendencies. More specifically, we explored the categorisation accuracy (whether the displayed emotion was correctly identified), misperception (which emotion an incorrect judgment was perceived to be), intensity (extent of the emotion signal strength) and emotional valence (the extent and direction of perceived affect) of six facial expressions of emotion from the Karolinska Directed Emotional Faces database. Complete data from N = 572 respondents are included. The dataset is available to other researchers and is provided on Figshare. Information concerning the data records, usage notes, code availability and technical validation are presented. Finally, we present demographic and correlational data concerning psychiatric symptoms and alterations in the perception of emotional faces.
PURPOSE:To obtain the subject spherical powder by copolymerizing a polymerizable monomer containing more than specific amount of an unsaturated polycarboxylic acid alkyl ester having two or more >=10C alkyl groups and a crosslinking monomer having two or more polymerizable groups at a specific ratio. CONSTITUTION:Spherical fine powder for cosmetic is produced by copolymerizing (A) 80-99wt.% of a polymerizable monomer (e.g. styrene, maleic acid or vinyl chloride) containing >=10wt.% of an unsaturated polycarboxylic acid alkyl ester having two or more >=10C alkyl groups (e.g. distearyl maleate) and (B) a crosslinking monomer having two or more polymerizable groups (e.g. divinyl ether). It is easily applicable to the skin and has affinity to cosmetic base, perfumery, etc., excellent water-resistance and perfume-retaining property and excellent effect to prevent the development of contrasting white color.
In-center hemodialysis (in HD mode), 3 times a week for 12 week duration. The patient will undergo regular HD treatment on the first treatment of the first week of study, after which, the patient will switch to the randomized dialyzer, from the second treatment to the end of study treatment. Blood sampling will be obtained at the hospital by trained personnel according to local routines.
Information system and subscript procedure in the course of on-line (direct) television transmission is a system that enables input of a great scope of shape of graphic TV subscript. This system is used mostly for TV sport broadcasting. In the PC server (9), exclusively by means of a mouse (22) and graphic interface on SVGA monitor (8), statistic data is entered in the data base on PC server (9), subscript card (15) is sending, to a TV mixer (2), video signals (4a and 5a), transferring video signals with desired statistics. With a server (9), by means of a network connection (12), commentator information terminals (13) are connected, sending statistical data to commentators, while, to Internet station (23), data are sent being intended for Internet site. By means of stations for data input (11), the number of operators (as needed) is increased for the entry of data, so that the information can be entered partially, and they are connected by means of a net connection (12) using the common data base on PC server (9). The measurement of time is performed by means of a specially designed timer (10) with only four tasters connected to a cursor (18) on the parallel port (16) of PC server (9). On the other part of a cursor, a printer (20) is attached for the printing of statistical data. With a cursor (18), a selection is performed for the using device.
Same as Usual Care, plus participants will have to deposit a certain amount of their own money as an incentive to quit smoking. Participants will be able to make additional voluntary deposits above the minimum amount. The participant will be refunded all deposits if he quits smoking at 3 months, as verified by a urine cotinine test. The participant will forfeit all deposits if he continues to smoke at 3 months, as verified by a urine cotinine test.
The optimal therapy for intermediate-risk patients with acute myeloid leukemia (AML) in first complete remission (CR1) is uncertain. Recent studies shown that microtransplantation (MST) can improve survival in AML-CR1 patients. However, a comparison study between the MST and nonmyeloablative stem cell transplantation (NST) is lacking. 156 intermediate-risk AML-CR1 patients aged 9 to 59 years were enrolled in this study. Patients with de novo AML enrolled in the study. Patient who has a HLA-identical donor is assigned to receive NST therapy with GVHD prophylaxis and who has no HLA-identical donor is assigned to receive MST therapy without GVHD prophylaxis.
BACKGROUND: Neuroblastoma exhibits substantial heterogeneity, which is intricately linked to various genetic alterations. We aimed to explore immune status in the peripheral blood and prognosis of patients with neuroblastoma with different genetic characteristics.
METHODS: We enrolled 31 patients with neuroblastoma and collected samples to detect three genetic characteristics. Peripheral blood samples were tested for immune cells and cytokines by fluorescent microspheres conjugated with antibodies and flow cytometry. Event-free survival (EFS) was analyzed using the Kaplan‒Meier method.
RESULTS: Twenty-two patients had genetic aberrations, including MYCN amplification in 6 patients, chromosome 1p deletion in 9 patients, and chromosome 11q deletion in 14 patients. Two genetic alterations were present in seven patients. The EFS was worse in patients with MYCN amplification or 1p deletion than in the corresponding group, whereas 11q deletion was a prognostic factor only in patients with unamplified MYCN. Changes in immune status revealed a decrease in the proportion of T cells in blood, and an increase in regulatory T cells and immunosuppression-related cytokines such as interleukin (IL)-10. The EFS of the IL-10 high-level group was lower than that of the low-level group. Patients with concomitant genetic alterations and a high level of IL-10 had worse EFS than other patients.
CONCLUSIONS: Patients with neuroblastoma characterized by these genetic characteristics often have suppressed T cell response and an overabundance of immunosuppressive cells and cytokines in the peripheral blood. This imbalance is significantly associated with poor EFS. Moreover, if these patients show an elevated levels of immunosuppressive cytokines such as IL-10, the prognosis will be worse.
The control arm (SAP only) will utilize an identical pump in functionality as the Tandem PLGS pump except for the lack of the PLGS feature and the associated user interface. This pump is called the t:slim X2 Dexcom G5 Mobile CGM Enabled pump, and is referred to in the protocol as the Tandem SAP pump.
The invention relates to scorpion aesthetic health care fluid and an extraction method thereof. The scorpion aesthetic health care fluid is prepared by blending two parts of the scorpion hydrolysate extracted from scorpion alone and the Chinese traditional medicine steeping fluid which is extracted from lucid ganoderma, salvia miltiorrhiza, medlar, donkey hide gelatin, peach seed, polygonatum, radix-polygoni multiflori and vanilla and so on by red wine or yellow wine according to certain proportion. The extraction method includes the extraction of scorpion hydrolysate and the extraction of the Chinese traditional medicine steeping fluid. The scorpion aesthetic health care fluid extracted by adopting the technical proposal of the invention can be taken alone, or can be prepared into health care medicated wine by being blended with wine according to certain proportion for drinking. The scorpion aesthetic health care fluid has the efficacies of activating blood and removing stasis, loosening the bowel to relieve constipation, enriching the blood, activating qi, calming the brain and the nerves, strengthening the muscles and bones, maintaining beauty and nourishing the face and the alike, and is especially suitable for the elderly women to drink. If being drunk frequently, the scorpion aesthetic health care fluid (or the blended wine) can nourish the five internal organs, strengthen the muscles and bones, moisten the skin and beautify the face and improve the immune function.
As a consequence of the discovery of IgE and the development of methods to identify and quantify anti-allergen IgE levels, interest in recent years has centered around the utilization of in vivo and in vitro diagnostic procedures. 7,9

Patients who react to a small quantity of antigen by skin testing can be classified as highly sensitive. Those who react only to large quantities of antigen can be classified as less sensitive. It would appear that there is at least a 50,000-fold range between the most and least sensitive individuals. On the other hand, certain patients who do not appear to have elevated quantities of specific anti-allergen IgE do have positive skin tests and have symptoms of allergic rhinitis. These patients are considerably less sensitive than patients with detectable levels of specific IgE antibody. 10

The current standard method of immunotherapy dates back to the earliest studies by Noon. As adapted for ragweed pollen extract, therapy is begun with a low dose, which has been shown to be tolerated by both experience and skin testing. 

The physician who undertakes immunotherapy should be concerned with the degree of sensitivity of the patient. This can be measured by skin test, leukocyte histamine release, or anti-allergen IgE levels. Strongly positive skin tests or high initial ragweed IgE and total IgE may be risk factors for systemic reactions. Less aggressive immunotherapy schedules may be indicated for such patients. Maintenance dose potency must be established by the physician's clinical observation and experience. 10,17

Serial fivefold or tenfold dilutions of the extract are used to make more dilute extract concentrations. Other concentrations can be prepared by appropriate dilution. In brief, the allergist can prepare any dilution of extract that is considered appropriate for the patient.
Pregnancy Category C: Teratogenicity studies have been performed in animals. Bepotastine besilate was not found to be teratogenic in rats during organogenesis and fetal development at oral doses up to 200 mg/kg/day (representing a systemic concentration approximately 3,300 times that anticipated for topical ocular use in humans), but did show some potential for causing skeletal abnormalities at 1,000 mg/kg/day. There were no teratogenic effects seen in rabbits at oral doses up to 500 mg/kg/day given during organogenesis and fetal development (>13,000 times the dose in humans on a mg/kg basis). Evidence of infertility was seen in rats given oral bepotastine besilate 1,000 mg/kg/day however, no evidence of infertility was observed in rats given 200 mg/kg/day (approximately 3,300 times the topical ocular use in humans). The concentration of radiolabeled bepotastine besilate was similar in fetal liver and maternal blood plasma following a single 3 mg/kg oral dose. The concentration in other fetal tissues was one-third to one-tenth the concentration in maternal blood plasma. 

An increase in stillborns and decreased growth and development were observed in pups born from rats given oral doses of 1,000 mg/kg/day during perinatal and lactation periods. There were no observed effects in rats treated with 100 mg/kg/day.

There are no adequate and well-controlled studies of bepotastine besilate in pregnant women. Because animal reproduction studies are not always predictive of human response, BEPREVE™ (bepotastine besilate ophthalmic solution) 1.5% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
A simple and accurate processor derating method includes: sampling a real-time counter/clock too obtain an initial time value T 1 ; resetting an Icnt Counter; incrementing the Icnt Counter to reflect the processing of each instruction; comparing the count in the Icnt Counter to a predetermined count IcntMax and if the count in the Icnt Counter is at least IcntMax, then sampling the RTC to obtain a second time T 2 . T 1  is then subtracted from T 2  to obtain a time difference DT which is multiplied by ((1−1/DF)−1) to obtain a Degradation Delay DD period, DF being a constant having a value which is the desired submodel performance with respect to full performance. The Degradation Delay is instituted, the RTC is sampled from time to time to obtain a test third time T 3 . When a test T 3  minus T 2  is not less than DD, then T 1  is set to T 3 . Then, the procedure is repeated for a next group of instructions. Optionally, further accuracy can be achieved by treating “wait-type” and/or “RTC-access-type” instructions specially and also by calculating a DDExtra period value which is used to adjust the next DD.
A system and method for automated behavioral activation is disclosed. The system and method automatically senses and tracks a user's activities and interactions over the course of a period of time. The tracked information may include sensing data and self-assessment data. In some embodiments, the sensing data may be from one or more sensors such as a global positioning system (GPS), a motion sensor, and a keyboard. The self-assessment data may be information input by the user. The system uses the tracked information to extract one or more user patterns. The system may also use the tracked information to calculate one or more mood balance scores and one or more mood balance indicators. The system then generates and provides feedback based on the pattern(s). The feedback may be used to implement a behavioral change plan, used to change the user's patterns to improve the user's overall wellbeing.
Diffusion tensor imaging (DTI) of the cervical spinal cord will be performed in patients with cervical spondylosis with varying degrees of symptoms and in healthy control subjects. Fibre tracking of main spinal tracts will be performed. Regions of interest will also be identified. Diffusion parameters will be extracted. This will allow quantification of degree of damage in of the spinal cord. The findings will be related to motor function measures and comprehensive clinical tests of sensory and motor function.
This invention relates toderivatives of antibacterial drug compounds. It also relates to pharmaceutical formulations of derivatives of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and in methods of treating bacterial infections. The antibacterial compounds of this invention are all based on the fluoroquinolone antibacterial family. These are synthetic broad-spectrum antibiotics. They were originally introduced to treat Gram negative bacterial infections, but are also used for the treatment of Gram positive strains.
PURPOSE: A liposome containing an elastine-like polypeptide(ELP) and a use thereof are provided to reduce the amount of drug release, and to maintain stable state. CONSTITUTION: A liposome contains: a lipid bilayer; an elastine-like polypeptide(ELP) in which hydrophobic group-containing moiety is conjugated; and a lipid bilayer stabilizing agent. The moiety is filled in the lipid bilayer. The lipid bilayer stabilizing agent is steroid which is incorporated in the lipid bilayer. The lipid bilayer stabilizing agent is selected from the group consisting of sterol or a derivative thereof, spingolipid or a derivative thereof, and a combination thereof. The lipid bilayer stabilizing agent is selected from the group consisting of cholesterol, beta-cholesterol, sistosterol, ergosterol, stigmasterol, 4,22 stigmastadiene-3-one, stigmasterol acetate, lanosterol, and a combination thereof. [Reference numerals] (AA) Calcein release(%); (BB) Cholesterol molar ratio: 25.8; (CC) Cholesterol molar ratio: 41; (DD) Temperature(°C);
Non-communicable diseases such as cardiovascular diseases, cancers, diabetes, and asthma are increasingly common due to factors like industrialization, urbanization, fast-paced life, stress, sedentary lifestyle, and unbalanced diet in the 21st century. These chronic conditions are a global epidemic, being among the top causes of death worldwide. Preventing these diseases through a nutritious diet is crucial, and scientific studies suggest that appropriate fruit intake, particularly apples, can lower the risk of various health issues. Apples, rich in bioactive compounds, vitamins, minerals, and dietary fiber, offer numerous health benefits. Regular consumption of apples helps reduce the risk of atherosclerosis, coronary artery disease, heart attacks, and diabetes, and also provides anti-asthmatic and anti-allergic effects. Apples aid in detoxification, improve digestion, enhance skin, hair, and nail health, and offer protection against cancers, Alzheimer's, and Parkinson's disease. Apples have been a dietary staple for centuries, consumed in various forms like juices, sauces, and ciders. The reviewed article emphasizes the health benefits of apples, highlighting their role in preventing civilization diseases. It also discusses the characteristics of common apple varieties and the impact of thermal processing on their nutritional content.
A method for treating canker sores with oral patches to speed healing and relieve pain. If certain medications are applied to a canker sore using an oral patch that restricts local flow of saliva and delivers the medication for at least 30 minutes and the patches are used for at least two or more hours per day, the method reduces the healing time for canker sores from typical 10-14 days to 2 days. The method can be used with various antimicrobials that speed the healing of canker sores, including penicillin and amoxicillin. The method can also be used with amlexanox and de-glycyrrhizinated licorice extract (DGL) which work by an unknown method. When used with DGL, the method also quickly relives canker sore pain and, if used before commencing a meal, typically relieves pain through a complete meal. A soluble oral patch with DGL is disclosed.
Patients assigned to HM Group(HM follow-up ONLY) will have Home Monitoring programmed ON. They will be seen in the office for device interrogations at the 3-month follow-up, and at 27 month follow-up. In the meanwhile the device status will be evaluated using HM only for the 9, 15 and 21 month scheduled follow-up. Patients will visit the hospital for device interrogation on 27 month final follow-up.
The SIMS programme is a community-based intervention which improvised the usual care (defined as the existing preschool oral health programme) offered by the Ministry of Health. The target group is 5-6-year-old preschool children and their parents. Apart from the usual care, the 5-6-year-old children receive interventions carried out by teacher in school and home tooth brushing supervision by parents. In addition, parents/guardians will receive OHE from the DT team, free toothbrush and toothpaste (1000ppm F) for child home tooth brushing and supervised child home tooth brushing for 6 months.
A makeup cosmetic has bright fluorescent coloring whilst having excellent transparency (being clear), and a cosmetic coloring material that is suitable for the cosmetic. A makeup cosmetic comprising (A) at least one kind of oil-soluble dye selected from the group consisting of red no. 218, red no. 223 and orange no. 201, (B) a higher fatty acid metal salt, and (C) oil, wherein the blending amount of pigment is not greater than 0.5 mass %, and the oil-soluble dye is dissolved or dispersed in the oil. The makeup cosmetic, achieves high luminance fluorescent coloring whilst also having excellent transparency, and can be used as a lip cosmetic, blusher or eye shadow.
Administering thereto-upfront loading of a bisphosphonate agent can be used to treat primary and secondary osteoporosis, other metabolic bone diseases, alleviation of bone pain, transplant and drug-induced bone loss, Paget's disease of bone, loosening of prosthesis, or metastatic bone diseases in mammals, preferably a human female or a male. A bisphosphonate drug can be administered as a loading dose upfront. Bisphosphonates can be administered by themselves or combined with, one or more other medications acting on bone, such as HRT, selective estrogen receptor modulating drug, calcitonin, parathyroid hormone, fluoride, androgen, sex-steroid hormone analogues, nitroglycerin growth factors and their analogs, peptides and proteins and their analogues, or any other novel therapeutic agents.  
     This new regimen of administration of an anti-osteoporosis drug (e.g., a bisphosphonate) by itself, or in combination with other medications, can be used in mammals, preferably human (in women and men) for prevention and treatment of osteoporosis (e.g., postmenopausal, glucocorticoid- or drug-induced osteoporosis and osteoporosis in men, etc.) and other metabolic bone disorders, metastatic bone disease, transplant bone disease, Paget's disease, and prevention and treatment of loosening of prosthesis. Disclosed are methods for rapid inhibition of bone resorption in mammals while obtaining a rapid reduction of bone turnover and biomarkers, rapid increase of bone mineral density, and rapid reduction of fractures. Also disclosed are pharmaceutical compositions and kits for carrying out the therapeutic methods disclosed herein.