anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Mitogen-activated protein kinase (MAPK) cascades play important roles in disease resistance in model plant species. However, the functions of MAPK signaling pathways in crop disease resistance are largely unknown. Here we report the function of HvMKK1-HvMPK4-HvWRKY1 module in barley immune system. HvMPK4 is identified to play a negative role in barley immune response against Bgh, as virus-induced gene silencing of HvMPK4 results in enhanced disease resistance whilst stably overexpressing HvMPK4 leads to super-susceptibility to Bgh infection. Furthermore, the barley MAPK kinase HvMKK1 is found to specifically interact with HvMPK4, and the activated HvMKK1DD variant specifically phosphorylates HvMPK4 in vitro. Moreover, the transcription factor HvWRKY1 is identified to be a downstream target of HvMPK4 and phosphorylated by HvMPK4 in vitro in the presence of HvMKK1DD. Phosphorylation assay coupled with mutagenesis analyses identifies S122, T284, and S347 in HvWRKY1 as the major residues phosphorylated by HvMPK4. HvWRKY1 is phosphorylated in barley at the early stages of Bgh infection, which enhances its suppression on barley immunity likely due to enhanced DNA-binding and transcriptional repression activity. Our data suggest that the HvMKK1-HvMPK4 kinase pair acts upstream of HvWRKY1 to negatively regulate barley immunity against powdery mildew.
Obesity remains a medical issue of great concern. Behavioural methods attempting to induce weight loss have largely failed because of a minimal understanding of stress- and depression-associated psychosocial correlates. This study extended research into the effects of exercise on weight loss through psychological pathways to improve treatments. Women with obesity (N = 108), participating in an original theory-driven cognitive-behavioural treatment within community-based health promotion centres, were evaluated over 24 months. Their mean scores on anxiety, depression, and anger at baseline were significantly higher than normative data from a general sample of United States women. Three serial mediation models were specified assessing mediation of the significant exercise→dietary change relationship. These yielded two significant paths: changes in exercise→anxiety→anxiety-associated emotional eating→self-efficacy→diet, and changes in exercise→depression→depression-associated emotional eating→self-efficacy→diet; and one non-significant path: changes in exercise→anger→anger-associated emotional eating→self-efficacy→diet. In a subsequent moderated moderation model, change in eating-related self-regulation moderated the relationship between changes in anxiety and anxiety-associated emotional eating, where exercise-associated self-regulation moderated effects from eating-related self-regulation. Dietary improvement was significantly related to weight loss over 6 (β = -0.40), 12 (β = -0.42), and 24 (β = -0.33) months. Findings indicated an increased treatment focus on the completion of moderate amounts of exercise for weight loss and, following that, attention to improvements in anxiety, depression, anxiety- and depression-associated emotional eating, self-efficacy for controlled eating, and the transfer of exercise-related self-regulation to eating-related self-regulation. Given the scope of the obesity problem, extensions of this research within field settings are warranted to accelerate application opportunities.
This is a single-arm, pre-post, window of opportunity trial. The tailored prehab program will be implemented for AI cancer patients preparing for cancer surgery for a 3-week duration in the preoperative window of opportunity. The prehab intervention is designed to modify inﬂammatory biomarkers in paired pre/post-intervention blood and tissue samples. 30 individuals who are 18-80 years old with a diagnosis of obesity-related solid tumor cancer, scheduled at least 3 weeks out from cancer surgery who are enrolled tribal members will be recruited over the duration of the study. Blood samples will be collected before and after the prehab, and inflammatory biomarkers will be measured in the paired pre/post blood sample. Unstained slides from the diagnostic biopsy and resected tumor specimen will be requested, and inflammatory biomarkers will be measured in the paired pre/post tissue sample.
The invention discloses application of fibronectin N-end and C-end heparin combining domain peptides to the preparation of a medicament for resisting liver cancer cell invasion and metastasis. Specifically, rhFNHN29 and rhFNHC36 can both inhibit adhesion and invasiveness capability of an MHCC97H cell. The concentration of the rhFNHC36 required for inhibiting the adhesion and invasiveness capability of the MHCC97H cell is lower. The depression effect is mediated by integrin alpha v beta 3 and can be released by a tyrosine phosphorylation enzyme inhibitor. The rhFNHN29 and the rhFNHC36 can promote focal adhesion kinase (FAK) tyrosine phosphorylation and the activity of AP-1 so as to reduce the expression of the integrin alpha v, the integrin alpha beta 3 and the integrin alpha beta 1 and the activity of matrix metallo proteinases (MMP)-9. Therefore, the rhFNHN29 and the rhFNHC36 can be applied to the preparation of the medicament for resisting liver cancer cell invasion and metastasis and have potential good application prospect in treating liver cancer cell invasion and metastasis.
Participants were to receive 7.5 milligrams (mg) of prasugrel orally, once daily if they weighed ≥60 kilograms (kg) and if pharmacodynamic (PD) measures indicated that the 5-mg prasugrel dose did not produce a steady-state PD response equivalent to inhibition of platelet activation (IPA) ≥25%. Because these criteria were not met, no participants received 7.5 mg of prasugrel.
The involvement of the right hemisphere, mainly the activation of the right cerebral regions, in recovery from post-stroke aphasia has been widely recognized. In contrast, the role of the right white matter pathways in the recovery from post-stroke aphasia is rarely understood. In this study, we aimed to provide a primary overview of the correlation between the structural integrity of the right hemispheric neural tracts based on the dual-stream model of language organization and recovery from post-stroke aphasia by systematically reviewing prior longitudinal interventional studies. By searching electronic databases for relevant studies according to a standard protocol, a total of 10 records (seven group studies and three case studies) including 79 participants were finally included. After comprehensively analyzing these studies and reviewing the literature, although no definite correlation was found between the right hemispheric neural tracts and recovery from post-stroke aphasia, our review provideds a new perspective for investigating the linguistic role of the right hemispheric neural tracts. This suggests that the involvement of the right hemispheric neural tracts in recovery from post-stroke aphasia may be mediated by multiple factors; thus, this topic should be comprehensively investigated in the future.
PURPOSE:To provide a new compound exhibiting excellent activity especially against Pseudomonas aeruginosa as an antibacterial agent, usable at a low concentration and useful as a medical antibacterial agent applicable even to the mucosa. CONSTITUTION:The compound of formula I (n is 3-10). The compound can be produced by reacting a 1,n-bis(N<3>-cyano-N<1>-guanidino)alkane of formula II with 4-aminobenzotrifluoride hydrochloride of formula III in a solvent (e.g. 2-ethoxyethanol) and treating the reaction product with an alkali. The starting compound of formula II is obtained by the reaction of a diamine with sodium dicyanamide. The amount of the compound of formula III is 2 equivalent or small excess to the compound of formula II. The width of the antibacterial spectrum of the compound is comparable to that of chlorhexidine which is a known antibacterial disinfectant. The agent exhibits excellent quick action and is applicable even to the mucosa to which the application of chlorhexidine is inhibited.
The Active Implementation Arm is comprised of the clinics that have started to receive the intervention, which is the ACHIEVE multi-component implementation strategy delivered by the Nurse Coordinators. All clinics (divided into 3 Cohorts) move from the Usual Care Arm into the Active Implementation Arm in sequential order (six months apart).
FIELD: organic chemistry. SUBSTANCE: invention describes new esters of sulfuric acid and sugar alcohols of the general formula (I)   where values A, X, B, m and p are given in p. 1 of the invention claim. Compounds show an antiproliferative activity in treatment and/or prophylaxis of arteriosclerotic alternations of vessel walls. Invention describes also a method of their synthesis and drugs based on compounds of the formula (I). EFFECT: improved method of synthesis, valuable medicinal properties. 6 cl, 97 ex
Introduction: Empyema secondary to pneumonia is a common condition. A significant number of patients will require surgical intervention for drainage and decortication. The aim of this study was to identify predictive factors for surgical intervention. Materials and Methods: The medical records of patients who were diagnosed with empyema secondary to pneumonia between the years 2010 and 2019 in a university hospital were included in the study. Patients who underwent surgical intervention were defined as group A and nonoperative treatment as group B. Clinical and laboratory data were collected from medical records and patients' chest computerized tomography (CT) scans were reviewed. Results: A total of 194 patients were included in the study-86 patients were included in group A and 108 patients in group B. Several parameters on admission were found to have a statistically significant correlation with surgical intervention: younger age, higher systolic blood pressure, and elevated white blood count. Multivariant analysis showed that younger age was found to have a statistically significant correlation with operative intervention (adjusted odds ratio = 0.971, P = .023). A statistically significant correlation between surgical intervention and survival (adjusted hazard ratio [HR] = 1.762, P = .046) and an inverse correlation between age and survival (adjusted HR = 0.050, P < .001) were found. Surgical intervention was associated with increased survival irrespective of age. A total of 42 CT scans were available for review. The mean density of the empyema fluid in group A was higher by 4.3 hounsfield units compared to group B (P < .067). Conclusions: Younger age was found to be associated with surgical intervention among patients suffering from empyema secondary to pneumonia. Surgical intervention was associated with increased long-term survival, irrespective of patients' age. Several radiologic characteristics were associated with the need for surgery in this study: empyema fluid density, pleural thickening, and fluid loculations. Additional prospective studies are required to ascertain these results.
One-anastomosis gastric bypass (OAGB) complications include inadequate weight loss, recurrent weight gain (RWG), and gastroesophageal reflux disease (GERD). Conversion to distal Roux-en-Y gastric bypass (D-RYGB) may be an effective conversional approach. A 38-year-old female underwent OAGB with a body mass index (BMI) of 53 kg/m2 and 43% initial total weight loss but had RWG to BMI of 44 kg/m2 over 5 years with refractory GERD symptoms. She underwent D-RYGB conversion, creating a 330 cm biliopancreatic limb, 75 cm Roux limb, and 400 cm total alimentary limb length to decrease the chance of malnutrition. At 2 weeks, GERD symptoms were resolved completely. By 12 months, 42% total weight loss was achieved with normal nutritional parameters. For RWG and refractory GERD after OAGB, conversion to D-RYGB can promote weight loss and GERD symptom control while preventing nutritional deficiencies.
PURPOSE: To obtain a therapeutic ration composition and an pharmaceutical composition for treatment of lipoprotein interference corresponding to cholesterol cacochymia by using Ribes nigrum lipid effective for significant increase of high density lipoprotein cholesterol. CONSTITUTION: This therapeutic ration composition (e.g. source, mayonnaise) or pharmaceutical composition for treatment of lipoprotein interference is produced by using Ribes nigrum lipid. The pharmaceutical composition is produced into the various forms for oral, enteral, rectum or parenteral administration. Preferably, a daily dose is 1-25g of Ribes nigrum lipid or 2-5g Ribes nigrum oil. The Ribes nigrum lipid significantly increases high density lipoprotein cholesterol and decrease low density lipoprotein cholesterol. The Ribes nigrum lipid is preferably protected by liposoluble antioxidant (e.g. ascorbyl palmitate).
The invention belongs to the technical field of a blood-pressure-reducing pillow, wherein the blood-pressure-reducing pillow is a health care product for reducing the pressure. The blood-pressure-reducing pillow has the following technical scheme and main use: with the somas of different persons, the hair types of the pillow are also different, so that the blood-pressure-reducing pillow has different treatment periods and has the effects of promoting the blood circulation, improving the sleep, relieving the heat and easing the pain, calming the heart and tranquilizing the mind, smoothing the main and collateral channels, and resuscitating. For example, the hyperpietic has the symptoms of high blood fat and high blood pressure, so that the medicine is applied to the hyperpietic according to the conditions of patients, and the blood-pressure-reducing pillow has the functions for reducing the blood fat and the blood pressure. The protection of the blood-pressure-reducing pillow is characterized in that acupuncture points of the head of the patient are simulated to increase the blood circulation of the brain and prevent blood vessels of the brain from being blocked. The blood-pressure-reducing pillow is a pure traditional Chinese medicine pillow, so that the medicine effect can enter into human body from the seven apertures in the human head to stimulate each acupuncture point and main and collateral channel. Some patients have medicine stimulation to the kidney and the stomach caused by taking the blood-pressure-reducing medicine for a long term to easily cause complications such as cerebral hemorrhage, cerebral infarction and the like. After being used, the blood-pressure-reducing pillow can mainly reduce the amount of the blood-pressure-reducing medicine, and has an obvious effect after being used for one to two moths (according to different somas of the patients).
The superficial medial collateral ligament (sMCL) of the human knee joint has functionally separate anterior and posterior fiber bundles. The two bundles are alternatively loaded as the knee flexion angle changes during walking. To date, the two bundles are usually not distinguished in knee ligament simulations because there has been little information about their material properties. In this study, we conducted quasi-static tensile tests on the sMCL of matured porcine stifle joints and obtained the material properties of the anterior bundle (AB), posterior bundle (PB), and whole ligament (WL). AB and PB have similar failure stress but different threshold strain, modulus, and failure strain. As a result, we recommend assigning different material properties (i.e., modulus and failure strain) to the two fiber bundles to realize biofidelic ligament responses in human body models. However, it is often inconvenient to perform tensile tests on AB and PB. Hence, we proposed a microstructural model-based approach to predict the material properties of AB and PB from the test results of WL. Such obtained modulus values of AB and PB had an error of 2% and 0.3%, respectively, compared with those measured from the tests. This approach can reduce the experimental cost for acquiring the needed mechanical property data for simulations.
The MWM technique was performed by asking patients to perform their painful movement (flexion, extension...). If pain was not reproduced, a combination of movements (flexion + rotation...) was performed. The most painful vertebral level was also evaluated with passive accessory vertebral movements. Then, with the patient in a seated position on a stretcher with the feet supported and a belt around the waist, the therapist performed a sustained glide over the targeted vertebra (spinous process) with the force and direction that relieved pain to the lowest level and asked the patient to perform his previous painful movement, as described by Mulligan. Three sets of 10 repetitions were performed, with 1-2 minutes rest between sets.
BACKGROUND: There is little research on adolescent bariatric surgery and mental health (depression, anxiety, etc.) with racial/ethnic minority adolescents. The objective of this study is to determine associations between adolescents' preoperative reports of depression, anxiety, and self-esteem and caregiver's' reports of the caregiver-adolescent relationship and interpersonal relationships with adolescents' BMI and differences based on race/ethnicity.
METHOD: Adolescents (ages 12-21) who underwent metabolic and bariatric surgery from June 2020 to November 2022 had their responses to specific items on the BASC-3 (anxiety, depression, and self-esteem) analyzed for associations with their body mass index (BMI) and with caregiver responses to the BASC-3 for adolescents' interpersonal skills and relationship with caregiver. Demographic differences on the BASC-3 were assessed. Pearson's correlations, independent t-tests, and ANOVA were used.
RESULTS: Caregivers who had higher t-scores for relationship with their adolescents had adolescents who had lower depression t-scores, lower anxiety t-scores, and higher self-esteem t-scores. Parents who had higher t-scores for their adolescents' interpersonal relations had adolescents who had lower depression t-scores, lower anxiety t-scores, and higher self-esteem t-scores. White adolescents had higher depression t-scores than Black and Hispanic adolescents. Black and Hispanic adolescents had higher self-esteem t-scores compared to White adolescents.
DISCUSSION: Some of the findings within the study regarding adolescents' race and ethnicity and mental health are not consistent with prior research, affirming the need for additional research of these sub-populations.
PURPOSE:A drug for external use, having a support with tight sealing property provided on the outside of an application drug containing a pharmacologically active substance dispersed in an adhesive base material, capable of preventing the evaporation of moisture and deterioration of a chemical, etc. and improving the absorption from the skin, and suitable for application to a part of the ears e.g. an ear lobe. CONSTITUTION:A drug for external use 1 obtained by filling an application drug 3 containing a pharmacologically active substance dispersed in an adhesive base material in a lightweight, easily handable, workable and moldable cuplike support 2. A sheet of easily relesable wax paper is attached to the surface of the application drug 3 to give a tightly sealed state, and the drug 1 is applied to a site corresponding to the desired pharmacological action by peeling the paper in use. Alternatively, a thin, slender and bendable strip part 14 is attached to a cup part 12, and the surface of the application drug 13 is applied to an ear lobe. The strip part 14 is bent at the bottom of the ear lobe to prevent the peeling thereof. Needlelike protrusions 35 a little longer than a cup part 32 are provided in the interior of the cup part 32, and penetrated into part of the corneal layer of the skin to increase the absorption ratio of the drug in application. The absorption of a high-molecular weight chemical can also be carried out.
<P>PROBLEM TO BE SOLVED: To provide a deliciously eatable health-assisting food demonstrating beauty effect such as antiobestic effect because of having excellent antioxidative effect.  <P>SOLUTION: This health-assisting food contains vinegared unrefined lees, and Crataegus cuneata Sieb.et Zucc. and/or its allied species. The vinegared unrefined lees comprises the strained lees of the unrefined lees of rice vinegar. As the Crataegus cuneata Sieb.et Zucc., its fruit or its extract is used.  <P>COPYRIGHT: (C)2003,JPO
BACKGROUND: Sleep loss is a key factor contributing to disease burden in people with atopic dermatitis (AD). Mitigating itch to improve sleep is an important outcome of AD treatment. This study explored the content validity and measurement properties of the Sleep-Loss Scale, a single-item rating scale for assessing itch interference with sleep in clinical trials of AD treatments.
METHODS: Concept elicitation and cognitive debriefing interviews were conducted with 21 adults and adolescents (12-17 years of age) with moderate-to-severe AD to develop a conceptual model of patient experience in AD and explore the content validity of the scale. Data collected from adults with moderate-to-severe AD enrolled in a phase 2b study (NCT03443024) were used to assess Sleep-Loss Scale's psychometric performance, including reliability, construct validity, and ability to detect change. Meaningful within-patient change (MWPC) thresholds were also determined using anchor-based methods.
RESULTS: Qualitative findings from concept elicitation highlighted the importance of sleep-loss related to itch in AD. Debriefing analysis of the Sleep-Loss Scale indicated that the scale was relevant, appropriate, and interpreted as intended. Trial data supported good reliability, construct validity and ability to detect improvement. MWPC was defined as a 1-point improvement using trial data, a finding supported by qualitative data.
CONCLUSIONS: The Sleep-Loss Scale provides a valid and reliable patient-reported measure of the impact of itch on sleep in patients with AD, and can detect change, indicating it is fit-for-purpose to evaluate the efficacy of AD treatments in moderate-to-severe patients.
INTRODUCTION: A urethral diverticulum can be defined as a pocket that forms from the lining of the urethra and protrudes into the surrounding tissue, a condition which causes voiding dysfunction and may result as a rare complication of hypospadias repair surgery.
CASE REPORT: We report the case of a 2-year-old child who presented to us in 2019 complaining of a thin forceful stream, ballooning of the ventral aspect of the penis while voiding, and post-void dribbling. He has a history of undergoing a tubularised incised plate urethroplasty for distal penile hypospadias at 18-months-old. Ultrasound showed increased post-void residual volume and cystourethroscopy confirmed a urethral diverticulum extending from the subcorona to the base of the penis. The patient underwent partial excision of diverticulum, urethroplasty, and meatoplasty. He was followed-up 3 months later with complete resolution of his symptoms and a normal urinary stream with no urethral ballooning or dribbling.
CONCLUSION: Urethral diverticulum may present as a complication post hypospadias repair. Although it is rare, we believe that it is important for the patient's parents to understand the possibility and know of the signs and symptoms in addition to attending regular outpatient clinic appointments in order to facilitate early management if needed. Furthermore, it is highly important for physicians to assess newborns for hypospadias before carrying out circumcision as it is a contraindication for the procedure.