anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Potassium Chloride in Sodium Chloride Injection, USP is supplied in single-dose flexible plastic containers as follows: 

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored between 20ºC to 25°C (68º F to 77°F). [See USP controlled room temperature.]; brief exposure up to 40°C (104°F) does not adversely affect the product. 

The container closure is not made with natural rubber latex. Non-PVC, Non-DEHP, Sterile.
Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves. These waves propagate through active relay in which stimulated neutrophils trigger their neighbors to release additional swarming cues. Unlike canonical active relays, we find these waves to be self-terminating, limiting the spatial range of cell recruitment. We identify an NADPH-oxidase-based negative feedback loop that is needed for this self-terminating behavior. We observe near-constant levels of neutrophil recruitment over a wide range of starting conditions, revealing surprising robustness in the swarming process. This homeostatic control is achieved by larger and more numerous swarming waves at lower cell densities. We link defective wave termination to a broken recruitment homeostat in the context of human chronic granulomatous disease.
An interferon-.beta./polyethylene glycol composite which has high bioactivit y; and a process for producing the composite at a high efficiency. The process for interferon-.beta. composite production is characterized by bonding interferon-.beta. to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides constituted of up to 5 sugar units, monosaccharides, sugar alcohols derived from these saccharides, and C2-6 polyhydric alcohols. The interferon-.beta. composite produced by the process has polyethylene glycol specifically bonded to the lysine located in the 19th or 134th position in the amino acid sequence of interferon-.beta..
INTRODUCTION: Magnetic resonance imaging (MRI)-determined atrophy of the nucleus basalis of Meynert (Ch4) predicts cognitive decline in Parkinson's disease (PD). However, interactions with other brain regions causing the decline remain unclear. This study aimed to describe how MRI-determined Ch4 atrophy leads to cognitive decline in patients with PD.
METHODS: We evaluated 137 patients with PD and 39 healthy controls using neuropsychological examinations, MRI, and 123I-ioflupane single-photon emission computed tomography. First, we explored brain areas with regional gray matter loss correlated with Ch4 volume reduction using voxel-based morphometry (VBM). We then assessed the correlation between Ch4 volume reduction and cognitive impairments in PD using partial correlation coefficients (rpar). Finally, we examined whether the regional gray matter loss mediated the association between Ch4 volume reduction and cognitive impairments using mediation analysis.
RESULTS: Our PD cohort was "advanced-stage enriched." VBM analyses revealed that Ch4 volume loss was correlated with volume reduction in the medial temporal lobe in PD (P < 0.05, family-wise error corrected, >29 voxels). Ch4 volume reduction was significantly correlated with verbal memory deficits in PD when adjusted for age, sex, total brain volume, and 123I-ioflupane uptake in the caudate (rpar = 0.28, P < 0.001). The mediation analysis revealed that the hippocampus mediated the effects of Ch4 volumes on verbal memory (average causal mediation effect = 0.013, 95 % CI = 0.006-0.020, P < 0.001).
CONCLUSION: Particularly in advanced-stage PD, Ch4 atrophy was associated with medial temporal lobe atrophy, which played an intermediary role in the relationship between Ch4 atrophy and verbal memory impairments.
PURPOSE: To investigate the clinical and pathological features of osteochondroma in maxillofacial region, and to summarize the clinicopathological features of rare osteochondroma malignant transformation in order to provide clinical guidance.
METHODS: From January 2018 to September 2023, a total of 171 patients with osteochondroma were retrospectively collected in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Their preoperative CT and clinicopathological features were analyzed.
RESULTS: Of the 171 patients with osteochondroma in maxillofacial bone, 66%(113/171) were females and 34% were male. Their age ranged from 11-76 with an average age was 44 years old. Of the 171 cases, 95.3%(163/171)in mandible condyle, 4%(7/171) in mandible processus coronoideus, and 0.5%(1/171) in zygomatic arch. The imaging findings showed that the thickness of cartilaginous cap was less than 1 cm in 98%(159/161) cases with condyle lesions. Only 2 cases(2/171, 1.1%) had malignant transformation. One was diagnosed with secondary chondrosarcoma, another developed low-grade osteosarcoma.
CONCLUSIONS: Osteochondroma in maxillofacial region mostly occurs in females, and most commonly located in condylar process, with a malignant change rate of 1.1%, which is similar to that of other parts of the body. Imaging findings have important guiding significance for the diagnosis of osteochondroma malignant change.
Background: Acromegaly is a slowly progressive disease caused by growth hormone (GH) excess. The estimated prevalence of the disease is 40 cases/1000000 population with 3-4 new cases/1000000 population per year. Most patients have classic manifestations due to acral and soft tissue change, including thickening of the calvarium, increased size of frontal sinus, enlargement of the nose, prognathism, and widely spaced teeth. The hands and feet are large, thickened and bulky. Acromegaly was also associated with many comorbidities including cardiovascular complications (acromegalic cardiomyopathy and arterial hypertension), respiratory complications (sleep apnea), metabolic complication (impaired glucose tolerance, diabetes mellitus), joint and bone complications (carpal-tunnel syndrome, osteoarthritis).3 The outcome of growth hormone level suppression after transsphenoidal surgery is far better for microadenomas (80-90%) than for macroadenomas (less than 50%). Furthermore, higher growth hormone level at diagnosis was related to poor prognosis. An early detection of acromegaly with early intervention was desirable. However, due to the slowly progression of the disease, times from symptom onset to diagnosis were 5.2 to 5.9 year4.

Current method to diagnose patients with acromegaly was to check serum GH and insulin-like growth factor 1 (IGF-1). However, tests for growth hormone and IGF-1 are currently unavailable in most hospitals in Taiwan and were expensive. We want to find a better screening tool for acromegaly with less expensive and high efficacy. Due to specific facial appearance of acromegaly, there were studies to recognize acromegaly by computer program1,2,3. They tried to develop computer programs to separate facial photographs of patient with acromegaly and normal subjects. The accuracy could reach 71.9% to 86%. Due to enlarged hand with increased soft tissue in patients with acromegaly, we also want to compare the difference of face, hand and feet morphology and face, hand and feet X ray of acromegaly patients with those of normal population. We hope to set a computer model to early detect acromegaly patients in Chinese people.
As per recommendations by the World Health Organization (WHO), iron supplementation in children should be restricted in malaria-endemic areas because of concerns that it can lead to an increased burden of malaria. Universal iron supplementation continues to be recommended, however, for women during pregnancy and 3 months postpartum. Observational studies have shown that iron deficiency in parturient women is associated with a marked reduction in the prevalence and density of malarial parasites in the placenta. Plasmodium infections in pregnant women have devastating effects on the foetus and neonate, causing low birth weight, intrauterine growth retardation, preterm delivery, spontaneous abortion, stillbirth and neonatal mortality. Based on our previous work, the Kenyan government is currently drafting legislation for mandatory iron fortification of industrially milled flour. Implementation of the new fortification policy means that pregnant women will receive iron through a combination of fortified foods and supplementation. The investigators are concerned about the safety of the high iron intake resulting from such a policy.
The invention discloses a preparation method of a Chinese medicine lotion for treating diet-stasis bedsore, belonging to the technical field of a preparation method of a Chinese medicine. In the prior art, generally sulfonamides and antibiotics are used for treating diet-stasis bedsore. The use of kanamycin has toxicity to auditory nerves and kidney, wherein, the former manifests as tinnitus, dysacusis, even permenant deaf, and the latter manifests as proteinuria, cylindruria and the like. The medicine lotion is prepared by immersing papaya, iris tectorum, carrot, buckwheat, medicated leaven, quince, sarcandra, ovate tylophora root and rhizome, obscured homalomena rhizome, asiatic toddalia root, pawpaw, Ficus simplicissima Lour, cortex acanthopanacis, radix achyranthis bidentatae, garter snake, Blumea balsamifera, Chinese photinia leaf, serissa serissoides, radix aucklandiae, and liquorice in water, then decocting with slow fire, filtering and removing slag. The prepared Chinese medicine lotion has little toxic and side effect and high curative rate. The use of the Chinese medicine avoids the adverse reactions, anaphylactic reactions and toxic reactions caused by using western medicines.
Participants in this group will receive an injection of VRC-HIVDNA044-00-VP at study entry and Months 1 and 2, followed by an injection of VRC-HIVADV038-00-VP at Month 6. There will be 13 study visits for this group.
This study is a phase 1/2, single-arm surgical clinical trial. The primary endpoint is the safety of da vinci robotic gastrectomy. The secondary endpoint is operative time, bleeding, bowel recovery, and hospital stay. In the clinic, informed consent is received from patient who is scheduled to undergo radical gastrectomy. After the general anesthesia, low midline transverse incision is made at suprapubic area. After inserting SP port into the peritoneal cavity, additional port is inserted via right flank that would be used for assistant's energy device and suction devices. Radical subtotal gastrectomy is perfromed using cardiere-forceps, monopolar scissors, and maryland forceps. Reconstruction after gastrectomy is decided according to surgeon's preference. three days after gastrectomy, if the diet build up is complete and the patients has no evidence of complication, the patient is discharged from the hospital. Four weeks after gastrectomy, the patient will be followed up at the clinic. Major complication event within 30days after gastrectomy will be analyzed as primary endpoint as well as other secondary endpoints.
OBJECTIVE: To report the first examples of ectopic salivary glands of TMJ ligaments & capsules.
METHODS AND MATERIALS: Nine subjects with chronic TMJ disorders were found incidentally to have ectopic salivary glands (choristomas) within or near damaged TMJ ligaments and capsules. Clinicopathologic characteristics of 12 TMJs are summarized.
RESULTS: The 9 subjects were ages 22-64 years (average = 43.0); 6 were female. Microscopic examination revealed major, almost complete ligament replacement by dense, avascular fibrous scar tissue in all but 1 sample. Chronic inflammatory cells were present in the stroma of 3 samples. A total of 33 lobular, independent salivary structures of variable sizes were embedded in or near ligaments and/or capsules. Half were multiple in the same joint; 13 were bilaterally located in the joints of a single subject, with 8 small glandular lobules in one TMJ. All glands consisted of histologically normal serous acini except 1 which showed a focal lobule of mucus acini and another comprised only of mucus acini. Serial sections showed no connection to parotid glands. Some choristomas showed the aging phenomena of fatty infiltrates (n = 7) and oncocytosis (n = 7). Additionally, 3 of the 12 TMJ samples contained preauricular lymph nodes, with 3 nodes in 1 joint and bilateral involvement in 1 subject. Of the 5 identified nodes, all but one was hyperplastic, with nonspecific inflammatory histiocytosis.
CONCLUSIONS: We report, for the first time, independent salivary gland choristomas (n = 33) within the soft tissues of the TMJ (n = 12), with one joint containing 8 such choristomas. All consisted of normal serous tissue except one, a mucus gland. Additionally, a fourth of TMJ surgical samples contained hyperplastic preauricular lymph nodes.
UNLABELLED: A biosensor based on field-effect transistors on silicon-on-insulator structures (SOI-biosensor) is a high-potential device for detection of biological molecules, for instance, such as troponin I; the biosensor allows conducting label-free real-time analysis. The aim of the study is the development of SOI-biosensor design for detection of acute myocardial infarction marker - troponin I. A notable feature of this design was the integration of two grounding electrodes directly onto the biosensor surface, which effectively nullified the static potential of the liquid sample and minimized physical breakdowns of biosensor elements.
MATERIALS AND METHODS: The highly specific anti-troponin I DNA aptamer was used as a receptor for specific detection of protein marker. Aptamer immobilization on the biosensor surface was carried out by physical adsorption. The analyzed range of target troponin I molecules concentration in the sample varied within 10-11 to 10-9 mol/L, mirroring clinical levels observed in myocardial infarction cases. During the experiment, a constant voltage of Vds=0.15 V was maintained.
RESULTS: The developed SOI-biosensor successfully detected target troponin I molecules at a concentration of 10-11 mol/L. The detection process exhibited an effective time of approximately 200-300 s per sample. Moreover, analysis of the detection process revealed a noticeable decrease in current within the source-drain circuit, indicative of the negatively charged complex formed by troponin I and anti-troponin I DNA-aptamer at the "liquid sample-nanowire" phase interface.
The study was planned as randomized controlled. Individuals included in the study wiil randomly allocate to the group receiving the supervised PBCST and the home exercise group. While the supervised exercise group receives PBCST for 2 days and 8 weeks in the clinic, the home exercise group will perform the same exercises at home for the same time as the brochures prepared for them. The exercise program will show progression at 2-week intervals. A session will be held for both groups to teach the basic principles of pilates and will not be counted in the 8-week program. At the beginning and end of treatment, individuals will be evaluated for isokinetic muscle strength, balance and postural sway, fatigue level, quality of life and functional capacity parameters. PBCST is thought to reduce postural sways and increase lower extremity muscle strength by increasing core stability with the effect of kinetic chain and increased stabilization.
The present invention belongs to Biaining as medicine for nasopharyngeal cancer resistance and a preparation method thereof. The Biaining is prepared from marine organisms and Chinese herbs. The Biaining is characterized in that the Biaining is prepared from 10 to 50% of crab, 10 to 50% of mole cricket shrimps, 10 to 40% of gleditsiae, 10 to 30% of paris polyphylla, 10 to 50% of astragalus root and 10 to 40% of spirulina, and the components are weighed according to the formula and are ground, soaked and decocted into medical liquid prepared into capsules or oral liquids. The Biaining can increase the therapeutic effect on nasopharyngeal cancer and interfere with the occurrence of the nasopharyngeal cancer. Matched with radiotherapy and used after the radiotherapy, the Biaining can suppress or remove the residual cancer cells of the organisms and the transferred cancer cells, suppress the propagation of EB viruses, increase the immune functions of the organisms, prolong the survival time of nasopharyngeal cancer patients, decrease the recurrence rate and increase the cure rate. The application to EB viruses IgA/VCA and IgA/EA patients with high positive nasopharyngeal cancer risk can reduce the morbidity of the nasopharyngeal cancer.
Connective tissue massage will be applied by an experienced physiotherapist for a total of 12 sessions 2 days a week for 6 weeks. While the patients are in sitting position, starting from the lumbosacral region, the lower thoracic, scapular, interscapular and cervical regions will be included in the treatment respectively.
A method (200) and system (100) for correlating genome data with EMR/PHR data is disclosed herein. The method (200) includes identifying a plurality of sources (102) of genome data. The method (200) also includes generating an index file for each of the plurality of genome files. The method (200) also includes transmitting each index file to a central depository (101). The method (200) also includes identifying electronic medical record (EMR) and/or personal health record (PHR) data at each source of the plurality of sources of genome data. The method (200) also includes correlating each genome file of the plurality of genome files with a corresponding EMR/PHR data.
<P>PROBLEM TO BE SOLVED: To economically form arachidonic acid and to provide a food formulated therewith.  <P>SOLUTION: The method for forming the arachidonic acid involves culturing microorganisms of the genus Mortierella sect. schmuckeri in a fermentation medium preferably containing composite nitrogen source components. The arachidonic acid is a precursor of eicosanoid important as a nutriment of an infant, and a mixed milk for the infant and a baby food having the improved content of the arachidonic acid are produced by formulating the microorganisms of the genus Mortierella sect. schmuckeri or a lipid separated from these microorganisms with a food.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The invention relates to an ageing-resisting and immunity-enhancing oral capsule prepared by multiple pure traditional Chinese drugs, which has the functions of reinforcing vital energy, promoting secretion of body fluids, strengthening spleen, tonifying lung, reinforcing kidney, raising energy, tonifying brain, diminishing inflammation, and promoting urination. The capsule comprises the following components: ginseng, large-head atractylodis rhizome, yam, lucid ganoderma, gynostemma pentaphylla, rehmannia glutinosa, shiandra, rhubarb, barbary wolfberry fruit, radix astragali and pine needles. The capsule has the advantages of reinforcing vital energy, promoting secretion of body fluids, strengthening spleen, tonifying lung, reinforcing kidney, raising energy, tonifying brain, diminishing inflammation, and promoting urination. The ageing-resisting and immunity-enhancing effect is good. In addition, the capsule can realize the purposes of treating the primary and the secondary aspects at the same time and of fewer possibility of relapse after cured. After long-time clinical practice, the total effective rate of the capsule can reach above 95%, so that the capsule enjoys a high reputation among patients.
The purpose of this study was to explore the effect of Semaglutide on intrauterine adhesions and discover new drugs for such adhesions. In this study, the cell model was simulated by TGF-β1-induced human endometrial epithelial cells, and the animal model was established through mechanical curettage and inflammatory stimulation. After co-culturing with TGF-β1 with or without different concentrations of Semaglutide for 48 h, cells were collected for RT-qPCR and Western blotting analyses. Three doses were subcutaneously injected into experimental mice once a day for two weeks, while the control group received sterile ddH2O. The serum and uterine tissues of the mice were collected. HE and Masson staining were used for the uterine histomorphological and pathological analyses. RT-qPCR and Western blotting were used for mRNA and protein expression analyses. Serum indicators were detected using ELISA kits. The results showed that Semaglutide significantly reduced the mRNA levels of fibrosis indicators ACTA2, COL1A1, and FN and inflammatory indicators TNF-α, IL-6, and NF-κB in the two models. Semaglutide improved endometrium morphology, increased the number of endometrial glands, and reduced collagen deposition in IUA mice. The results also showed that Semaglutide could inhibit vimentin, E-Cadherin, and N-Cadherin in the two models. In summary, Semaglutide can ameliorate fibrosis and inflammation of intrauterine adhesions as well as inhibit epithelial-mesenchymal transition in IUA models.
I. Research object: In the outpatient department of a medical center in a medical center in the north, the case was collected, and the sample was selected conveniently. The patients who met the following sample selection conditions were selected, and 128 patients who agreed to participate in the study and filled out the consent form were studied by Random Allocation. The software software generates a random assignment list, which is then assigned to the experimental group and the control group.

2.The number of samples is calculated The number of samples required is calculated by G power (version 3.1.9.2) statistical software (Faul, Erdfelder, Buchner, \& Lang, 2009), and the repeated measures ANOVA of the F test is used to compare the difference between the two groups (between factors) due to lack of intervention. The reference data of the effect size of the measure, the estimated measure should be moderately beneficial for the degree of decision-making, so according to the cohen's rule (Cohen, 1988) f2 is 0.30, the significant level α is 0.05, and the statistical power value is 0.05. It is 0.80, repeated measurement 3 times, the correlation between repeated measurements is 0.5, the total number of samples is estimated to be 86, each group is 43, and in addition, in order to make the secondary effect variable, there are enough samples, and consider The exit and omission values were about 20%. Therefore, 128 end-stage renal patients were selected from the hospital outpatient nephrology case management database. About 64 people in the experimental group and the control group participated in the study.

3. Intervention measures The intervention measures in this study were discussed with the nephrologist and CKD health teachers. Based on theoretical considerations, both the experimental group and the control group can accept the introduction and selection of renal replacement therapy, but the decision support measures are different, and the experimental group provides decision support. Measures include the use of CKD Guardian as a decision-maker and the development of medical decision aids by e-book software, and the application and decision-directed model complemented by introduction and selection. The implementation steps include team discussion, option discussion and decision making. The conversation is conducted while the control group is introduced with traditional care care.