anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND OBJECTIVES: Levetiracetam is a widely used antiseizure medication. Recent concerns have been raised regarding the potential prolongation of the QT interval by levetiracetam and increased risk of sudden cardiac death. This could have profound implications for patient safety and for prescribing practice. This study assessed the potential association of levetiracetam with cardiac outcomes related to QT interval prolongation. We compared outcomes of patients taking levetiracetam with those taking oxcarbazepine as a comparator medication that has not been associated with prolongation of the QT interval.
METHODS: The sample included patients who were newly prescribed levetiracetam or oxcarbazepine from January 31, 2010, to December 31, 2019, using administrative claims data from the OptumLabs Data Warehouse (OLDW). The analysis focused on a combined endpoint of sudden cardiac death or ventricular arrythmia, which are both linked to QT interval prolongation. We used a new user design and selected oxcarbazepine as an active comparator with levetiracetam to minimize bias. We used propensity score weighting to balance the levetiracetam and oxcarbazepine cohorts and then performed weighted Cox regressions to evaluate the association of levetiracetam with the combined endpoint.
RESULTS: We identified 104,655 enrollees taking levetiracetam and 39,596 enrollees taking oxcarbazepine. At baseline, enrollees taking levetiracetam were older, more likely to have diagnosed epilepsy, and more likely to have diagnosed comorbidities including hypertension, cerebrovascular disease, and coronary artery disease. In the main analysis, we found no significant difference between levetiracetam and oxcarbazepine in the rate of the combined endpoint for the Cox proportional hazards model (hazard ratio [HR] 0.79, 95% CI 0.42-1.47) or Cox regression with time-varying characteristics (HR 0.78, 95% CI 0.41-1.50).
DISCUSSION: When compared with oxcarbazepine, levetiracetam does not correlate with increased risk of ventricular arrythmia and sudden cardiac death. Our finding does not support the concern for cardiac risk to indicate restriction of levetiracetam use nor the requirement of cardiac monitoring when using it.
CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that sudden cardiac death and ventricular arrythmia are not more frequent in patients older than 17 years newly prescribed levetiracetam, compared with those prescribed oxcarbazepine.
FIELD: biotechnology, virology, immunology, genetic engineering. SUBSTANCE: nucleotide sequence corresponding to genome of classic swine fever virus (CSFV) or mutant presents nucleotide sequence of C- strain of classic swine fever virus indicated in sequence at identification = 1, complement or RNA-equivalent of such nucleotide sequence or it comprises nucleotide sequence encoding sequence of amino acids 268-494 in sequence at identification = 1 carrying mutation in nucleotide sequence encoding amino acids 690-877, or nucleotide sequence encoding amino acids 690-1063 of sequence = 1 and containing additionally mutation in sequence of amino acids 268-494. Mutation is taken among deletions or substitutions by one or more amino acids that alternate at least one epitope. Obtained nucleotides are components of diagnostic set and pestviral vaccine against classic swine fever virus. Invention allows to diagnose pestviruses and develop vaccines against classic swine fever virus. Invention can be used for development of vaccine against classic swine fever virus (CSFV). EFFECT: valuable properties of polypeptide and vaccine. 14 cl, 5 dwg, 8 tbl
PROBLEM TO BE SOLVED: To obtain the subject new compound which possesses fungicidal and insecticidal activities against various fungi and shows antiasthematic activity and immunosuppressive activity. SOLUTION: The compound of the formula and the dicarboxylic acid formed by ring-opening of the diketofuran structure in the above-stated compound, its ester or its salt. The compound of the formula is obtained by inoculating Zopfiella curvata No. 37-3 strain (FERM P-13067) belonging to the genus Zopfiella into a culture medium containing eutrophic sources (e.g glucose, soybean powder, calcium carbonate, etc.) to grow it aerobically and perfuming, for example, shake culture or depth through-flow stirring culture at 20-37 deg.C and pH 4-8 for 48-360 hours to get the resultant culture product followed by usual separation and purification (e.g. reduced pressure concentration, lyophilization, solvent extraction, etc.).  The objective compound possesses fungicidal activity against various fungi and is useful as an agricultural and horticultural fungicide and as an antiasthematic agent and an immunosuppresant in medicines.
The objective of this study is to examine the possible therapeutic advantages of administering perioperative dronabinol to individuals who are undergoing unilateral total knee arthroplasty (TKA). With the utilization of contemporary regional anesthetic procedures and peripheral nerve blocks, pain management is typically effective in the immediate aftermath of total knee arthroplasty (TKA) within the first day after surgery. Rebound pain is shown to occur on the second day following postoperative discharge (POD2), once the analgesic blocks administered during the procedure have ceased to be effective. Previous studies have suggested that dronabinol, a synthetic form of THC, may have potential analgesic properties. Our goal is to find out if giving dronabinol before surgery could lower the number of opioids that people need on postoperative day 2 (POD2) in people who are having total knee arthroplasty (TKA). This research could provide valuable insights into alternative pain management strategies for TKA patients, potentially minimizing opioid-related side effects and improving overall patient outcomes.
This study seeks to intervene just in time for families at highest risk of early life obesity and obesity-related comorbidities (such as Type 2 diabetes), to prevent intergenerational obesity and metabolic syndrome for Hispanic families. For those children exposed to gestational diabetes (GDM) or maternal overweight/obesity in utero, there is a critical need for effective early life strategies for secondary prevention of obesity, to interrupt intergenerational transmission. This study will offer community-embedded coaching to families learn how to responsively feed their babies using 2 models: group visits and text-based. The investigators will also assess responsive sleep practices; i.e. paying attention to an infant's sleep cues as well as hunger cues, breaking the feeding to sleep association, and not overfeeding at night. Infant and toddler sleep, both duration and quality, has not been well studied in this population for early life obesity prevention. This study is specifically exploring pathways from prenatal gestational diabetes and maternal overweight/obesity to dysregulated infant feeding and sleep. Few interventions around infant sleep exist for the Hispanic population, or resources in Spanish-language around sleep coaching; let alone analyses on parents' self-efficacy and behavior change. In this study, the investigators aim to better understand the complex socioenvironmental drivers of infant sleep and feeding behaviors, and the prenatal risks related to infant rapid weight gain, in order to target modifiable factors in this population.
Opioids are frequently prescribed for patients undergoing procedures such as spinal fusion surgery for the management of chronic back pain. However, the association between a preoperative mental health illness, such as depression or anxiety, and opioid use patterns after spinal fusion surgery remain unclear. Therefore, we performed a systematic literature review in accordance with PRISMA guidelines to identify articles from the PubMed Database that analyzed the relationship between preoperative mental health illness and postoperative opioid usage after spinal fusion surgery on June 1, 2023. The Methodological Index for Nonrandomized Studies (MINORS) was utilized to evaluate the quality of included articles. Seven studies with 139,580 patients and a mean MINORS score of 18 ± 0.5 were included in qualitative synthesis. The most common spine surgery performed was lumbar fusion (59 %) and the mean age across studies ranged from 50 to 62 years. The range of postoperative opioid usage patterns analyzed ranged from 1 to 24 months. The majority of studies (6/7; 86 %) reported that a preoperative diagnosis of mental health illness was associated with increased opioid dependence after spinal fusion surgery. Preoperative use of opioids for protracted periods was shown to be associated with postoperative chronic opioid dependence. Consensus findings suggest that having a preoperative diagnosis of a mental health illness such as depression or anxiety is associated with increased postoperative opioid use after spinal fusion surgery. Patient comorbidities, including diagnoses of mental health illness, must be considered by the spine surgeon in order to reduce rates of postoperative opioid dependence.
Impaired angiogenesis, bacterial infection, persistent severe pain, exacerbated inflammation, and oxidative stress injury are intractable problems in the treatment of chronic diabetic ulcer wounds. A strategy that effectively targets all these issues has proven challenging. Herein, an in-situ sprayable nanoparticle-gel composite comprising platinum clusters (Pt) loaded-mesoporous polydopamine (MPDA) nanoparticle and QX-314-loaded fibrin gel (Pt@MPDA/QX314@Fibrin) was developed for diabetic wound analgesia and therapy. The composite shows good local analgesic effect of QX-314 mediated by near-infrared light (NIR) activation of transient receptor potential vanilloid 1 (TRPV1) channel, as well as multifunctional therapeutic effects of rapid hemostasis, anti-inflammation, antioxidation, and antibacterial properties that benefit the fast-healing of diabetic wounds. Furthermore, it demonstrates that the composite, with good biodegradability and biosafety, significantly relieved wound pain by inhibiting the expression of c-Fos in the dorsal root ganglion and the activation of glial cells in the spinal cord dorsal horn. Consequently, our designed sprayable Pt@MPDA/QX314@Fibrin composite with good biocompatibility, NIR activation of TRPV1 channel-mediated QX-314 local wound analgesia and comprehensive treatments, is promising for chronic diabetic wound therapy.
1377312 Substituted amido-benzophenones CASSELLA FARBWERKE MAINKUR AG 4 May 1973 [12 May 1972] 21295/73 Heading C2C The invention comprises benzophenone derivatives of the formula and their acid addition salts, wherein R 1 and R 2 represent H or a C 1 -C 4 alkyl or alkenyl radical, R 3 represents CN, CONH 2 , COOH, COOCH 3 or COOMe where Me is a metallic cation, n is 1 or 2, m is 1, 2 or 3, and the rings A and B may be substituted. They may be obtained by reacting a compound of the formula with a compound of the formula one of X and Y represents R 2 NH- and the other is a halogen. Products wherein m is 2 or 3 may also be obtained by reacting a compound of Formula II wherein X is R 2 NH- with a compound containing an aliphatic double bond of the formula Products wherein R 3 is CN and is in the α-position in relation to the amino group of the side chain, a compound of Formula II wherein X is R 2 NH with an aldehyde or ketone of the formula and with HCN or an alkali metal cyanide. Compounds in which R 3 is carbomethoxy or carboethoxy may be saponified to give compounds in which R 3 is COOH or be subjected to give compounds in which R 3 is CONH 2 . Examples which illustrate the production of these compounds are given. Compounds of Formula I have a sedative action on the central nervous system. Some of these compounds also have muscle-relaxing and aggression-inhibiting properties. They may be administered as tablets, suppositories, capsules, emulsions or suspensions or in conjunction with diluents or carriers. 2 - (N - Methyl - N - # - chloropropionylamino)- 5-chlorobenzophenone is obtained by condensing 2-methylamino-5-chlorobenzophenone with #- chloropropionyl chloride in toluene. 2 - (Methylamino - acetamido) - 5 - ehlorobenzophenone is obtained by condensing 2-(chloroacetamido)-5-chlorobenzophenone in dioxane with methylamine in methanol.
[GB1377312A]
On top of the PA intervention described in Arm 1, the participants will guided for moderate weight loss with a MED diet, low in simple carbohydrates that will be rich in plants and polyphenols and low in processed meat. The diet will include 1oz/day of walnuts, 3-4 cups/day of green tea and \~500cc green shake/dinner based on specific strain of duckweed \[Wolffia globose, "Mankai"\], an aquatic plant, which might serve as a plant protein source. All the above will be provided free of charge.
Patient volunteers will also undergo a C-11 PiB PET scan. This procedure utilizes a common radiotracer that is used routinely in clinical PET scans and will be purchased here from PETNET and certified for human use. All PET scans will be performed by a certified PET technologist at the Vanderbilt University Institute of Imaging Science.
Emergency situations involving the ears, nose, and throat (ENT) area can pose considerable challenges for clinicians and often require an interdisciplinary approach due to the involvement of different organ systems. To avoid damage to highly relevant sensory and perception organs and life-threatening bleeding or respiratory complications, strategies that are as quick and targeted as possible are necessary. This article aims to provide an overview of ENT emergency management strategies. The entire spectrum from simple conservative to highly complex surgical measures plays a role here, both diagnostically and therapeutically. Aspects such as bleeding, respiratory problems, inflammation, hearing disorders, vertigo, facial palsy and injuries to the head and neck area are discussed. In addition, important topics such as preventive measures and possible complications are also addressed to ensure optimal patient care.
OBJECTIVES: We aimed to cluster patients with rheumatoid arthritis (RA) based on comorbidities and then examine the association between these clusters and RA disease activity and mortality.
METHODS: In this population-based study, residents of an eight-county region with prevalent RA on 1 January 2015 were identified. Patients were followed for vital status until death, last contact or 31 December 2021. Diagnostic codes for 5 years before the prevalence date were used to define 55 comorbidities. Latent class analysis was used to cluster patients based on comorbidity patterns. Standardised mortality ratios were used to assess mortality.
RESULTS: A total of 1643 patients with prevalent RA (72% female; 94% white; median age 64 years, median RA duration 7 years) were studied. Four clusters were identified. Cluster 1 (n=686) included patients with few comorbidities, and cluster 4 (n=134) included older patients with 10 or more comorbidities. Cluster 2 (n=200) included patients with five or more comorbidities and high prevalences of depression and obesity, while cluster 3 (n=623) included the remainder. RA disease activity and survival differed across the clusters, with cluster 1 demonstrating more remission and mortality comparable to the general population.
CONCLUSIONS: More than 40% of patients with prevalent RA did not experience worse mortality than their peers without RA. The cluster with the worst prognosis (<10% of patients with prevalent RA) was older, had more comorbidities and had less disease-modifying antirheumatic drug and biological use compared with the other clusters. Comorbidity patterns may hold the key to moving beyond a one-size-fits-all perspective of RA prognosis.
Ketamine will be administered as intravenous infusions with infusion rates ranging from 0.1 mg/kg/hr to 0.30 mg/kg/hr. To maintain blinding, both active and placebo will be infused at similar infusion rates (mL/hr).
Parathyroid hormone, released from the parathyroid gland, plays an important role in keeping the ionized calcium in between the reference values in body. Precise control of ionized calcium is particularly necessary to ensure the optimal function of physiological processes such as providing intracellular signaling, performing neuromuscular functions and bone metabolism. When there is a decrease in the level of ionized calcium in the systemic circulation due to any reason, increased calcium concentration is maintained as a result of the increased absorption of calcium from the kidneys, bones and intestines into the blood via increased parathyroid hormone. An error caused by any of the components in this regulatory system may cause excessive parathyroid hormone release, causing primary, secondary or tertiary hyperparathyroidism. Primary hyperparathyroidism (PHPT) is a common endocrinological disorder, which is characterized by excessive release of parathyroid hormone, resulting in a defect in the regulation of calcium metabolism. PHPT, is the third most common endocrine disease and is the most common cause of hypercalcemia. Today, PHPT is approximately 0.25-0.66% of the population and it is seen as 3: 1 times more common in women than men. While the incidence of the disease increases with age, it increases dramatically after 50 years of age. The clinical presentation of PHPT ranges from asymptomatic disease to the classical symptomatic disease of renal and / or musculoskeletal complications. Low plasma 25 Hydroxyvitamin D level; bone mineral density, muscle strength, preservation of postural stability and functional performance of the musculoskeletal functions such as disruption caused by the person's walking and balance activities are adversely affected.In addition, fatigue, pain, and body mass index, as a result of the increase in the functional capacity of the person is seriously reduced quality of life and psychosocial status is adversely affected. Although there are studies related to bone mineral density, muscle strength and function, instability, fatigue, etc., which are secondary to PHPT and cause a significant decrease in functional capacity, there is no study to investigate the effect of M. quadriceps Femoris ,which has a key role in the evaluation of functional capacity, muscle fatigue on the gait and balance parameters in the pre and post-treatment period in the literature. The aim of this case-control study is to investigate the effect of Quadriceps Femoris muscle fatigue protocol on gait, gait symmetry and balance parameters before and after parathyroidectomy in patients PHPT and to compare that parameters of these individuals with healthy controls with similar demographic characteristics that included in the control group.
PURPOSE:To effectively utilize a waste cocoon by washing it with water, immersing and thermally dissolving it in an aq. soln. of an alkaline earth metal salt, removing the alkaline earth metal from the resulting soln. by electrodialysis, and utilizing the obtd. soln. for applications in agriculture, stock raising, and the marine products, electrical, machine, and chemical industries. CONSTITUTION:A waste cocoon washed with water is immersed and thermally dissolved in an aq. soln. of an alkaline earth metal salt. The resulting soln. is diluted with water and subjected to electrodialysis to remove the alkaline earth metal from the soln. For example, 10g of a waste cocoon and 100g of a calcium salt are put into 800g of water and dissolved in it by heating at 100-130 deg.C for about 1hr, thus giving an aq. high-viscosity soln. The soln. purified by electrodialysis can be used for a sound-absorbing material, an antifreeze mixture, a frost-preventing agent, an antifogging agent, air cleaning, a food additive, feed, a soil conditioner, a medical ammonia absorbent, a refrigerant, a noncombustible material, etc.
The invention belongs to the technical field of drug preparation development, in particular to a liposome drug carrier and a preparation method and application thereof. The liposome drug carrier includes the following ingredients: cetylic acid and cholesterol. By freeze drying or rotary drying the ingredients transform into membranes. Through the subsequent hydration and filming the final products are acquired. The liposome drug carrier can automatically form lipid microspheres which are quite stable. At the same time the drug carrier preserves the advantages of traditional liposome, namely, the drug carrier has a structure similarity to the bimolecular lamellar membrane structure of biological plasma membrane. The drug carrier has the advantages of excellent biological adaptability, stability, simple production and high encapsulation efficiency and the like. The liposome drug carrier can be used to carry biphosphonate drugs with a consistent and unified particle diameter, high encapsulation efficiency and high stability. The carrier has negative charges and can further enhance the ability that the drug enters cells. Compared with traditional lecithin liposome the carrier enhances the effects on macrophages.
OBJECTIVES: After renal transplant, identification of early graft dysfunction is crucial for graft survival. We aimed to assess the perfusion of the transplanted kidney using near-infrared spectroscopy and to see any correlations between regional saturation and serum creatinine and urine output.
MATERIALS AND METHODS: We included male and female patients, aged 18 to 65 years, with end-stage renal disease and undergoing living related donor renal transplant in our study. Near-infrared spectroscopy was used for continuous monitoring of regional saturation. Urine output and serum creatinine were recorded at baseline and then every 24 hours until postoperative day 5.
RESULTS: Among 21 patients included in the study, mean age was 30.23 ± 4% at postoperative day 5. We found a significant negative correlation between regional saturation and serum creatinine at all time intervals (P < .05). A significant negative correlation between regional saturation and urine output was observed at baseline and at 24, 72, 96, and 120 hours (P < .05). Four patients developed postoperative complications. A significant change in regional saturation was detected at 40 hours, 1 hour, 2 hours, and 48 hours earlier by near-infrared saturation in 4 patients compared with other traditional indexes of renal function monitoring.
CONCLUSIONS: Monitoring with near-infrared spectroscopy is feasible and safe in postoperative renal transplant patients. Near-infrared spectroscopy may be projected as a surrogate tool for real-time monitoring of renal perfusion in renal transplant recipients.
This study proposes a chronic wound therapeutic strategy based on extracellular matrix (ECM) biomimetics and immune regulation. The hydroxybutyl chitosan/diatom biosilica hydrogel (H/D) which can regulate the immune microenvironment, is prepared from hydroxybutyl chitosan (HBC) as matrix to construct the bionic ECM and diatom biosilica (DB) as structural active unit. The hierarchical porous structure of DB provides strong anchoring interface effect to enhance the mechanical strength of hydrogel, while maintaining its favorable temperature phase transition behavior, improving the material's fit to the wound and convenience of clinical use. Silicates released from DB in H/D accelerate the transition of wounds from inflammation to proliferation and remodeling. In cellular and diabetic rat models, H/D reduces inflammation (induces conversion of M1-type macrophages to M2-type), induces angiogenesis (1.96-fold of control), promotes fibroblast proliferation (180.36 % of control), collagen deposition, keratinocyte migration (47.34 % more than control), and re-epithelialization. This study validates a possible biological mechanism for H/D bioactive hydrogel-mediated regulation of the immune microenvironment and provides a simple synergistic dressing strategy.