anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine. SUBSTANCE: strain of Bifidobacterium infantis 79-43 is isolated from health infant intestine. Strain B. infantis 79-43 is multiplicated actively on nutrient media of different compositions used for production of bacterial preparations. Strain accumulates industrial biomass to 16-24 h of culturing and contains lg 8/1 ml microbe cells. Strain ferments milk to 24 h culturing and forms clot that shows good taste and organoleptic properties. Strain produces acids and inhibits growth of pathogenic and opportunistic microflora. Strain shows resistance to some antibacterial preparations. EFFECT: strain indicated above, enhanced effectiveness of strain. 3 tbl
This invention relates to the new applications of the Rose liquid in the preparation of the eye drops. The Rose liquid can be prepared by distillation from the mixture of rose and water with ratio of 1:1-10 by weight. Distilled water is better controlled by 2-20% of the total lolume of water per hr. distilling time is controlled by 30-60min. The eye drops by using the distilled rose water (as the main raw material) can effectively remit the eye tiredness, dryness, itching with fine curative effect to the anaphylaxis or inflammation or infection of the eye cornea and conjunctiva but with very light irritation. The eye drops also has the character of high effectiveness, light toxin, less untoward effect. It has broad application foreground.
PURPOSE:To obtain the titled cosmetic for decomposing peroxides and peroxide lipid on the skin, not damaging effect of cosmetic of its own and feeling in use, preventing inflammation, etc. of the skin, by blending a solid powdered cosmetic comprising an oil component as an essential component with an amine. CONSTITUTION:Powder is blended with an oil component and an amine selected from the group consisting of primary - quaternary amines having 1-3 hydroxyalkyls (with the proviso that the other substitutent groups are H or lower alkyl), alkylamine(primary), thioaklylamine(primary), aromatic hydrocarbon containing 1-2 aminogroups, ethylenediaminetetraacetic acid(salt), and trietylenediamine. An amount of the amine blended is preferably 0.01-10wt% based on the cosmetic. Both peroxides formed by light and heat and peroxide lipid derived from sebum formed on the skin are decomposed with the amine, the effect of the cosmetic of its own and feeling in use are not damaged, and inflammation, etc. of the skin can be prevented.
OBJECTIVE: In this study, we investigated the development of the Wnt signaling pathway in vitamin D (VitD) to improve systemic lupus erythematosus in mice to breakthrough clinical treatment approaches.
METHODS: Body weight changes were recorded during rearing. Antinuclear antibodies (ANA), anti-dsDNA, and anti-snRNP were detected in the mouse serum using an enzyme-linked immunosorbent assay. Apoptosis of Th1 and Th2 immune cells in mice was detected using flow cytometry. Reverse transcription polymerase chain reaction was used to detect the expression of T-bet, GATA3, and Wnt3a mRNA in the spleens of each group. Western blot analysis was performed to detect the expression of Wnt1, p-β-catenin, β-catenin, glycogen synthase kinsase3β (GSK-3β), Wnt3a, c-myc, and cyclin D1 protein in mice spleens. β-catenin in mice spleen was visualized using immunohistochemistry.
RESULTS: VitD did not substantial reduce the body weight of MRL/LPR mice, whereas the inhibitor did. VitD notably decreased the concentrations of ANA, anti-double-stranded DNA, and anti-snRNP in the serum of MRL/LPR mice and alleviated apoptosis of Th1 and Th2 cells. VitD markedly increased the expression of T-bet and GATA mRNA in the spleen of MRL/LPR mice and consequently increased the levels of Wnt3a and β-catenin. Western blot analysis revealed that the levels of GSK-3β, p-β-catenin, Wnt1, Wnt3a, c-myc, and cyclin D1 could be reduced by VitD, compared with MRL/LPR. Immunohistochemistry demonstrated that the expression of β-catenin was the most pronounced in the spleen of MRL/LPR mice, and the expression level of β-catenin decreased substantially after VitD intervention.
CONCLUSIONS: VitD can further inhibit the nuclear translocation of β-catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt/β-catenin signal pathway.
PROBLEM TO BE SOLVED: To obtain a non-fermentable anti-choline agent relatively stable against heat and acid, high in safety, mild in the quality of sweetness, little in aftertaste, and having an excellent administration touch, by combining stevia as a sweet component with a specific anti-choline component. SOLUTION: This anti-choline agent contains (A) one or more kinds of medicinal substances selected from the group of belladonna alkanoid, isopropamide iodide, Seopoliae Folium extract, and Daturae Folium extract, and (B) stevia. The component B is preferably e.g. the stevia containing revaudioside A in a large amount. The effective compounding amount of the component B is 10-50mg/d for a healthy adult, and compounded in an amount of 0.01-0.05 pt.wt. per pt.wt. of the component A.
Patients receive cisplatin IV over 6 hours on day 1, doxorubicin IV over 1-15 minutes on days 1 and 2 and sorafenib PO BID on days 3-14 of cycles 1 and 3. Patients also receive gemcitabine IV over 90 minutes on day 1, oxaliplatin IV over 2 hours on day 1 and sorafenib PO on days 1-14 of cycles 2 and 4. Patients may undergo surgery, if tumors are resectable, or receive an additional 4 cycles of the treatment. Patients may optionally undergo blood sample collection on study.
After pectus excavatum is done, intravenous patient controlled analgesia device with fentanyl is connected. Then, regional analgesia is performed for additional analgesia; ultrasound guided erector spinae plane block is performed using 0.25% ropivacaine (total 1 ml/kg) bilaterally. Plasma concentration of ropivacaine at baseline, and 5, 10, 20, 30, 60, 120 minutes after ropivacaine injection will be measured.
Azithromycin for Injection, USP contains the active ingredient azithromycin, an azalide, a subclass of macrolide antibacterial drug, for intravenous injection. Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O -methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-hepta-methyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749. Azithromycin has the following structural formula:

  
Azithromycin, as the monohydrate, is a white crystalline powder with a molecular formula of C38H72N2O12·H2O and a molecular weight of 767.

Azithromycin for Injection, USP consists of azithromycin monohydrate USP and the following inactive ingredients: citric acid and sodium hydroxide. Sodium hydroxide is added to adjust the pH. Azithromycin for Injection, USP is supplied as white to off-white lyophilized powder in a single-dose vial for intravenous administration. Each vial contains azithromycin monohydrate USP equivalent to 500 mg of azithromycin, 384.5 mg citric acid, and sodium hydroxide. Reconstitution, according to label directions, results in approximately 5 mL of azithromycin for intravenous injection with each mL containing azithromycin monohydrate USP equivalent to 100 mg of azithromycin, 76.9 mg citric acid, and sodium hydroxide.
Solid tumors are characterized by hypoxic areas, which are prone for macrophage infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) to support tumor progression. Therefore, the crosstalk between TAMs and tumor cells is of current interest for the development of novel therapeutic strategies. These may comprise induction of an iron- and lipid peroxidation-dependent form of cell death, known as ferroptosis. To study the macrophage - tumor cell crosstalk we polarized primary human macrophages towards a TAM-like phenotype, co-cultured them with HT1080 fibrosarcoma cells, and analyzed the tumor cell response to ferroptosis induction. In TAMs the expression of ceruloplasmin mRNA increased, which was driven by hypoxia inducible factor 2 and signal transducer and activator of transcription 1. Subsequently, ceruloplasmin mRNA was transferred from TAMs to HT1080 cells via extracellular vesicles. In tumor cells, mRNA was translated into protein to protect HT1080 cells from RSL3-induced ferroptosis. Mechanistically this was based on reduced iron abundance and lipid peroxidation. Interestingly, in naïve macrophages also hypoxia induced ceruloplasmin under hypoxia and a co-culture of HT1080 cells with hypoxic macrophages recapitulated the protective effect observed in TAM co-cultures. In conclusion, TAMs provoke tumor cells to release iron and thereby protect them from lipid peroxidation/ferroptosis.
Multifunctional compounds are provided that readily crosslinkin situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
Tracheoesophageal fistula (TEF) and esophageal atresia (EA) are rare congenital anomalies occurring in approximately 1 in 2500 to 3500 neonates. We present a neonatal patient diagnosed with EA/TEF in conjunction with pulmonary agenesis requiring definitive repair via median sternotomy. The child was born at 33 weeks gestational age with post-delivery respiratory distress necessitating intubation. A nasogastric tube was unable to be passed. After subsequent imaging, TEF and pulmonary agenesis were diagnosed. During planned staged repair with ligation of TEF via standard right thoracotomy approach, significant ventilatory compromise was encountered. Due to concern for ventilatory compromise and anatomical variance limiting visualization, a median sternotomy approach was utilized for definitive repair. This exposure and repair were successful and may be considered for cases with complex pulmonary malformation limiting standard thoracotomy. To our knowledge, this is only the second reported case of a successful TEF/EA repair using a median sternotomy approach.
A computer-based system for providing coordinated health monitoring, emergency response, and medical record delivery. The system can include computing devices configured to process emergency-related indicators and data. The system can also include monitoring devices communicatively linked to the computing devices. The monitoring devices can be configured to monitor a particular area for the emergency-related indicators and data, wherein the monitoring devices detect speech, sounds, images and other detectable emergency-related indicators. The monitoring devices can also be configured to transmit the emergency-related indicators and data to the computing devices. Furthermore, the system can include a module linked to the monitoring devices and configured to execute on the computing devices. The module can analyze the transmitted emergency-related indicators and data to determine whether there is an emergency, communicate with a monitoring service to validate that an emergency exists, and provide access to patient records to authorized personnel, when an emergency exists.
INTRODUCTION: Esophageal safety following radiofrequency (RF) left atrial (LA) linear ablation has not been established. To determine the esophageal safety profile of LA linear RF lesions, we performed systematic esophagogastroduodenoscopy in all patients with intraesophageal temperature rise (ITR) ≥ 38.5°C.
METHODS AND RESULTS: Between December 2021 and July 2023, a total of 200 consecutive patients with atrial tachyarrhythmia (ATA) underwent linear ablation with posterior dome (roof or floor) or posterior mitral isthmus line transection. Patients with ITR ≥ 38.5°C were scheduled for esophageal endoscopy ~3 weeks after ablation. Patient and ATA characteristics, procedural parameters, endoscopy findings and ablation lesion data were collected and analyzed. One hundred thirty-three out of 200 (67%) patients showed ITR ≥ 38.5°C during LA linear ablation. ITR (with maximal temperature of 45.7°C) was more frequently observed during floor line ablation (82% of cases). ITR was less observed during roof line ablation (34%) and posterior mitral isthmus ablation (4%). Endoscopy, performed in 115 patients after 24 ± 10 days, showed esophageal ulceration in four patients (two patients Kansas City classification [KCC] 2a and two patients KCC 2b). No patient showed esophageal perforation or fistula.
CONCLUSION: Temperature rise during LA linear ablation is frequent and ulceration risk exists, particularly when floor line is performed. Safety measures are needed to avoid potential severe complications like esophageal perforation and fistula.
The invention discloses a traditional Chinese medicine for treating the convulsive disease caused when channels and collaterals are obstructed by evil. The traditional Chinese medicine is characterized by being prepared from, by weight, 15 parts of Iodes vitiginea (Hance) Hemsl., 9 parts of scallion roots, 30 parts of Microtoena insuavis (Hance) Prain ex Dunn, 15 parts of blumea balsamifera, 10 parts of aralia continentalis kitag, 9 parts of Heracleum scabridum Franch., 9 parts of Nepeta angustifolia C.Y.Wu, 15 parts of pyrethrum tatsienense (Bur. et Franch.) Ling, 30 parts of Poncirus trifollata(L.)Raf., 15 parts of common bluebeard herb, 15 parts of angle snail, 15 parts of roots or herb of Snowcreeper Porana, 30 parts of herb of Indian Adenosma, 15 parts of cassia twigs, 15 parts of geranium wilfordii maxim, 15 parts of eleutherococcus leucorrhizus, 10 parts of Oxalis acetosella L., 12 parts of rhizome of Kirilow Rhodiola and 4 parts of liquorice. All the components in the formula can coordinate with one another, have a synergistic effect, and have the functions of expelling wind, removing cold, eliminating dampness and harmonizing yin together. The traditional Chinese medicine can effectively treat the convulsive disease caused when channels and collaterals are obstructed by evil. In recent years, the traditional Chinese medicine is used by multiple patients, and it shows that the effective rate reaches 95%.
Everolimus-eluting stents have been studied extensively in ongoing clinical studies. The safety and effectiveness of the everolimus drug and polymer combination have been studied extensively in the SPIRIT Clinical Trial Program. The PROMUS Element stent is currently being studied in the PLATINUM Clinical Trial Program. The PROMUS Element stent is also being evaluated in PROMUS Element Plus US post-approval studies and the ongoing Platinum China study. This study is designed to provide post-market surveillance information on the PROMUS Element™ and PROMUS Element™ Everolimus-Eluting Coronary Stent System (PROMUS Element and PROMUS Element Plus Stent System) after it has been approved by SFDA (State of Food and Drug Administration) in China. The study will evaluate clinical outcomes for subjects receiving the PROMUS Element and PROMUS Element plus stents over 5 years in a real world setting according to post approval requirements from SFDA.
FIELD: medicine.SUBSTANCE: method involves a patient's face exposure to full-spectrum natural or artificial light of light intensity not less than 2000 lux for 1-2 hours a day combined with or followed by an exercise load. Additionally, an eating disorder is typed and corrected using psychophysiological techniques. A caloric value of a diet is specified by reducing the patient's regular mean daily energy requirement per a percentage equal to the patient's body weight index with lipid restriction to 40-60 g/day for a period of 6 months with fasting days once every 1-2 weeks. The exercise load is performed in an anaerobic gradual regimen with no weight and resistance on muscle groups of the upper body and waist, with a power load on muscle groups of the lower body until muscular fatigue in the number of 2-3 sets with a rest. They are combined with or followed by a prolonged exercise load at least 4 times a week for 40-60 min in an aerobic regimen with 2-3 acceleration episodes of 3-5 minutes. They are combined with drug-free procedures aiming at improving the regional blood flow, improving the muscular tonus of the anterior abdominal wall and sides, the greater muscle groups of the upper body. If the patient has no insulin resistance syndrome or the sugar blood level less than or equal to 6.1 mmole/l, preparations and biologically active additives containing lipoic acid and vitamin Bare administered. If the patient suffers from insulin resistance syndrome and/or a fasting glucose level of more than 6.1 mmole/l, the preparations of biguanidines containing metformin are prescribed. Diet mistakes require prescribing preparations of lipase inhibitors containing orlistat.EFFECT: higher therapeutic effectiveness taking into account a degree of obesity with reducing side effects of therapy.9 cl, 6 tbl, 3 ex
Grape pomace (GP), a by-product of wine production, contains bioactive polyphenols with potential health benefits. This study investigates the anti-inflammatory properties of a polyphenolic fraction derived from GP, obtained by ultrasound-microwave hybrid extraction and purified using ion-exchange chromatography. In the inflammation model, mice were divided into six groups: intact, carrageenan, indomethacin, and three GP polyphenols treatment groups. Paw edema was induced by subplantar injection of carrageenan, and the GP polyphenols were administered intraperitoneally at doses of 10, 20, and 40 mg/kg. The anti-inflammatory effect was evaluated by measuring paw volume, and expression of inflammatory markers: cyclooxygenase-2 (COX-2), myeloperoxidase (MPO), and cytokines (IL-1β and IL-6), along with lipid peroxidation levels. The GP polyphenols significantly reduced paw edema and expression levels of COX-2, MPO, and cytokines in a dose-dependent manner effect, with the highest dose showing the greatest reduction. Additionally, lipid peroxidation levels were also decreased by GP polyphenols treatment at doses of 10 and 20 mg/kg. These findings suggest that ultrasound-microwave extraction combined with amberlite purification proved to be effective in obtaining a polyphenolic-rich fraction from GP. Thus, GP polyphenols may serve as a natural anti-inflammatory and antioxidant agent for treating inflammation and oxidative stress-related diseases.
PURPOSE: To determine the interrater reliability (IRR) of thyroid eye disease (TED) photographic assessment using the VISA classification. To assess whether a VISA grading atlas improves ophthalmology trainees' performance in photographic assessment of TED.
METHODS: A prospective, partially randomized, international study conducted from September 2021 to May 2022. Online study invitation was emailed to a volunteer sample group of 68 ophthalmology college accredited consultants and trainees, and 6 were excluded from the study. Participants were asked to score 10 patient photographs of TED using only the inflammation and motility restriction components of the VISA classification. IRR was compared between groups of practitioners by their level of experience. A clinical activity grading atlas was randomized to 50% of the ophthalmology trainees.
RESULTS: Overall rater ICC was 0.96 for inflammation and 0.99 for motility restriction. No statistically significant difference in IRR between rater groups was identified. Trainees with a grading atlas had the highest IRR for inflammation (ICC = 0.95). Each subcomponent of the inflammation and motility restriction components of VISA classification had an ICC considered good to excellent. The mean overall rater score was 4.6/9 for inflammation and 3.5/12 for motility restriction. For motility restriction there was a reduced mean score variance among all raters when scoring photographs with more severe motility restriction.
CONCLUSION: IRR using the inflammation and motility restriction components of the VISA classification was excellent. A VISA grading atlas improved trainee performance in grading inflammation.
NEW MATERIAL:A compound shown by the formula I [R is group shown by the formula II(m is 1-10; A and B are H, or linked to form single bond, when m is >=2, A and B may be combination of the above-mentioned two cases); R' is aliphatic hydrocarbon of 1-24C saturated or unsaturated straight or branched chain]. EXAMPLE:1-O-Farnesyl-3-O-methyl-2-O-2',3'-dihydroxypropyl-glycerin. USE:Useful as an emulsifying agent, oil agent, wetting agent, viscosity builder, etc., especially as a component for cosmetic. A compound having chemical stability, low irritation to the skin, and surface active properties. PREPARATION:A terpene alcohol shown by the formula ROH is reacted with an epihalohydrin, to give a compound shown by the formula III. This compound is then reacted with an alcohol shown by the formula R'OH, to give a compound shown by the formula IV, which is etherified to give a compound shown by the formula V. An acid anhydride is added to this compound to give a compound shown by the formula VI, which is hydrolyzed, to give a compound shown by the formula I .
Individuals in the this group will receive 24 sessions of Clinical Pilates training 3 times a week for 8 weeks. During the training, individuals will be asked to wear compression stockings during the 8 weeks. An educational booklet will be given to the each group.
Carcinogenesis: In a lifetime carcinogenicity study in CD-1 mice asenapine was administered subcutaneously at doses up to those resulting in plasma levels (AUC) estimated to be 5 times those in humans receiving the MRHD of 10 mg twice daily. The incidence of malignant lymphomas was increased in female mice, with a no-effect dose resulting in plasma levels estimated to be 1.5 times those in humans receiving the MRHD. The mouse strain used has a high and variable incidence of malignant lymphomas, and the significance of these results to humans is unknown. There were no increases in other tumor types in female mice. In male mice, there were no increases in any tumor type.

In a lifetime carcinogenicity study in Sprague-Dawley rats, asenapine did not cause any increases in tumors when administered subcutaneously at doses up to those resulting in plasma levels (AUC) estimated to be 5 times those in humans receiving the MRHD.

Mutagenesis: No evidence for genotoxic potential of asenapine was found in the in vitro bacterial reverse mutation assay, the in vitro forward gene mutation assay in mouse lymphoma cells, the in vitro chromosomal aberration assays in human lymphocytes, the in vitro sister chromatid exchange assay in rabbit lymphocytes, or the in vivo micronucleus assay in rats.

Impairment of Fertility: Asenapine did not impair fertility in rats when tested at doses up to 11 mg/kg twice daily given orally. This dose is 10 times the maximum recommended human dose of 10 mg twice daily given sublingually on a mg/m2 basis.