anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Insomnia is a common sleep disorder, often associated with some mental disorders or mental health concerns, especially when accompanied by depression or anxiety, but very limited research has been reported in China. The purpose of this study was to investigate the prevalence of insomnia and associations with depression, anxiety in Chinese adults.
METHODS: We conducted this large-sample cross-sectional study (51774 adults) in Guangdong province from October to December 2022. We used multistage stratified equal-volume random sampling under a complex sampling design to select the sample and standardized structured questionnaires to collect the necessary information. Descriptive analysis and logistic regression model were used for statistical analysis.
RESULTS: The weighted prevalence of insomnia was 24.8 %. Insomnia was significantly associated with depression (OR:11.29, 95 %CI: 9.58-13.29), and anxiety (OR:10.98, 95 %CI: 8.78-13.72). Risk factors as being associated with insomnia were female, higher years of education, suffering from chronic diseases, previous drinking and current drinking, while protective factors were living in a rural area, married or cohabited, divorce or separation and being older. Risk factors as being associated with depression in the insomnia group included 10-16 years of education and suffering from chronic diseases, while protective factors were being older, married or cohabited, and normal BMI. Risk factors associated with anxiety in the insomnia group included 7-12 years of education and suffering from chronic diseases, while protective factors were being older, married or cohabited, and having a normal BMI.
CONCLUSIONS: Insomnia is associated with the development of depression and anxiety. Women and unhealthy lifestyle were at high risk for insomnia, had chronic diseases is an important factor, and insomnia with depression or anxiety.
OBJECTIVES: The translocation of intestinal flora has been linked to the colonization of diverse and heavy lower respiratory flora in patients with septic ARDS, and is considered a critical prognostic factor for patients.
METHODS: On the first and third days of ICU admission, BALF, throat swab, and anal swab were collected, resulting in a total of 288 samples. These samples were analyzed using 16S rRNA analysis and the traceability analysis of new generation technology.
RESULTS: On the first day, among the top five microbiota species in abundance, four species were found to be identical in BALF and throat samples. Similarly, on the third day, three microbiota species were found to be identical in abundance in both BALF and throat samples. On the first day, 85.16% of microorganisms originated from the throat, 5.79% from the intestines, and 9.05% were unknown. On the third day, 83.52% of microorganisms came from the throat, 4.67% from the intestines, and 11.81% were unknown. Additionally, when regrouping the 46 patients, the results revealed a significant predominance of throat microorganisms in BALF on both the first and third day. Furthermore, as the disease progressed, the proportion of intestinal flora in BALF increased in patients with enterogenic ARDS.
CONCLUSIONS: In patients with septic ARDS, the main source of lung microbiota is primarily from the throat. Furthermore, the dynamic trend of the microbiota on the first and third day is essentially consistent.It is important to note that the origin of the intestinal flora does not exclude the possibility of its origin from the throat.
INTRODUCTION: The clinical manifestations of acute severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) suggest a dysregulation of the host immune response that leads to inflammation, thrombosis, and organ dysfunction. It is less clear whether these dysregulated processes persist during the convalescent phase of disease or during long COVID. We sought to examine the effects of SARS-CoV-2 infection on the proportions of classical, intermediate, and nonclassical monocytes, their activation status, and their functional properties in convalescent COVID-19 patients.
METHODS: Peripheral blood mononuclear cells (PBMCs) from convalescent COVID-19 patients and uninfected controls were analyzed by multiparameter flow cytometry to determine relative percentages of total monocytes and monocyte subsets. The expression of activation markers and proinflammatory cytokines in response to LPS treatment were measured by flow cytometry and ELISA, respectively.
RESULTS: We found that the percentage of total monocytes was decreased in convalescent COVID-19 patients compared to uninfected controls. This was due to decreased intermediate and non-classical monocytes. Classical monocytes from convalescent COVID-19 patients demonstrated a decrease in activation markers, such as CD56, in response to stimulation with bacterial lipopolysaccharide (LPS). In addition, classical monocytes from convalescent COVID-19 patients showed decreased expression of CD142 (tissue factor), which can initiate the extrinsic coagulation cascade, in response to LPS stimulation. Finally, we found that monocytes from convalescent COVID-19 patients produced less TNF-α and IL-6 in response to LPS stimulation, than those from uninfected controls.
CONCLUSION: SARS-CoV-2 infection exhibits a clear effect on the relative proportions of monocyte subsets, the activation status of classical monocytes, and proinflammatory cytokine production that persists during the convalescent phase of disease.
This is a Phase 2, multi-center, randomized, double-blind, placebo-controlled, 2-arm parallel group design trial in patients at risk for renal damage following open heart surgery. After screening and baseline assessments, eligible patients will be randomized 1:1 to either 2 doses of 128 mg ilofotase alfa, or 2 doses of placebo control. Randomization will be stratified by baseline eGFR and type of surgery. The patient will be treated with the investigational product (ilofotase alfa or placebo) at the same day before and after the surgery (Day 1). Follow-up clinic visits will be performed daily up to Day 5 for efficacy, safety, and pharmocokinetics assessments. A safety follow-up can be performed by telephone at Day 28. At Day 61, an end of trial visit will be done at site for efficacy, safety, and anti-drug antibodies assessments.
Splenic ischemia (SI) is a common finding during sleeve gastrectomy (SG) procedures; however, reports are still lacking. In this study, we retrospectively analyzed our SG patients to understand better the incidence rate and implications of SI. Patients' data from the beginning of the year 2021 until December 2022 that underwent bariatric surgery at our university hospital were retrospectively analyzed. Patient surgery video was reviewed by all the authors to investigate the incidence of SI. Thereafter, the corresponding patient age, height, weight, BMI, and their postoperative day 1 (POD1) temperature and blood routine test results (patients were routinely discharged at POD2) were collected and analyzed. 204 patients were included in this study. The mean age and preoperative BMI were 31.7 ± 7.4 years old and 38.8 ± 5.6 kg/m2, respectively. SI was observed in 18 cases (8.8%). 30-day readmission rate was seen in 3 patients (1.5%, all without SI during the primary surgery). There was no statistical difference with regard to the POD1 temperature and blood test results between the patients with and without SI. The incidence of SI during sleeve gastrectomy-related procedures is a common finding in our study. We did not observe significant differences postoperatively between the patients with and without SI before discharge. Further study is needed to understand the mechanism for the incidence of SI during SG.
The invention discloses a fibroin polypeptide, and relates to the biotechnology polypeptide preparation field. The fibroin polypeptide has the sequence of RRTDKHIAILNNQEIQKFP. A preparation method comprises the preparation steps: cutting 500 g of silkworm cocoon obtained after cleaning and drying into pieces, and adding into 500-1000 ml of deionized water; boiling, carrying out ultrasonic treatment for 1-2 hours, and at the same time, slowly stirring; after the solution is cooled, adding hydrolase, and carrying out a reaction for 30-60 minutes at the temperature of 20-40 DEG C; centrifuging at the speed of 2000-3000 rpm for 5-10 minutes, and taking a supernatant liquid; adding the supernatant liquid into a weak-acidity buffer solution with the pH of 6.0-6.5, stirring, centrifuging at the speed of 10000-15000 rpm for 30-60 minutes, and thus obtaining a precipitate; re-dissolving the precipitate in a buffer solution with the pH of 5.5-6.0, and with a dextran gel chromatography technology, separating to obtain the polypeptide with the molecular weight of 2-3 KDa. The fibroin polypeptide can be used as an additive in preparation of cosmetics. Antigen experiment results show that the polypeptide has no antigenicity. The polypeptide has no antigenicity, and experiments of in-vitro inhibition of tyrosinase confirm that the polypeptide has a whitening function.
Patients receive veliparib PO BID twice daily on days 1-21 of each cycle and carboplatin IV over 30 minutes on day 1 of each cycle. Cycles repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT or MRI and may optionally undergo biopsies throughout the study. Patients undergo blood sample collection during screening and on study.
We present a case of a male term neonate with lethargy, hypotonia, hypoventilation and severe encephalopathy. The infant had a history of two siblings who died in the neonatal period from unclear causes. The infant exhibited skin and hair abnormalities, including desquamation of the extremities, angular stomatitis, cheilitis, neonatal acne and thin, sparse hair. Additionally, the infant had a tall stature; long, slender fingers and toes; and facial dysmorphism characterised by a long, narrow face with increased interpalpebral distance. The condition deteriorated rapidly, and unfortunately, death occurred before a definitive diagnosis could be established. Tandem mass spectrometry suggested low methionine and clinical exome sequencing identified a nonsense mutation in the MTHFR gene.
PURPOSE OF REVIEW: Discussing the rationale and current evidence for left ventricular unloading in cardiogenic shock.
RECENT FINDINGS: Microaxial flow pumps (MFP) and intra-aortic balloon pumps (IABP) augment cardiac output while simultaneously unloading the left ventricle (e.g. reducing left ventricular pressure), thereby targeting a key mechanism of cardiogenic shock. A recent randomized trial has shown a mortality reduction with MFP in selected patients with cardiogenic shock, strengthening the rationale for this strategy, although the evidence for the IABP is so far neutral. MFP/IABP can also be used concomitantly with veno-arterial extracorporeal membrane oxygenation (va-ECMO) to alleviate the va-ECMO-related increase in left ventricular afterload, to facilitate weaning and ultimately to improve myocardial recovery and prognosis of affected patients. However, the use of MFP/IABP in this indication solely relies on retrospective data, which need to be interpreted with caution, especially as these strategies are associated with more complications. Currently ongoing randomized trials will help to further clarify the role of left ventricular unloading in patients on va-ECMO.
SUMMARY: Left ventricular unloading addresses a key mechanism of cardiogenic shock, with strong evidence to support MFP use in selected patients, but further randomized controlled trials are required to clarify the role of different devices/strategies for the overall shock population.
Participants will be sequentially administered with Treatment B, C then A. Each treatment will be separated by a washout period of 7 days.
Children aged 0-5 years with unilateral UPJO. Unilateral UPJO will be defined as an hydronephrosis needing of surgical correction on the basis of at least 2 of the following criteria: APDP ≥ 30 mm, SRF less than 40% at the Mag3S, SRF with delta \> 10% at follow-up Mag3S compared with the first Mag3S, delayed wash-out following diuretic administration, progressive increase of the APDP at follow-up kidney ultrasounds, 4th degree hydronephrosis.
Provided is a gene sequence for endo-alginate lyase Alg2A derived from Flavobacterium sp. strain S20 freshly isolated from soil samples, and a preparation method and application therefor. Also provided is a method of preparing the alginate lyase Alg2A, i.e. a technical method utilizing genetic engineering, in which the Alg2A gene is cloned to an Escherichia coli expression vector to obtain an Escherichia coli recombinant strain that can heterologously express said lyase. Using said strain to heterologously express the prepared alginate lyase Alg2A has the function of decomposing sodium alginate and preparing sodium alginate oligosaccharide. The present invention applies to the chemical, agricultural, and food industries, as well as to livestock feed processing, to the field of medicine, and to the field of genetic engineering of marine algae.
INTRODUCTION: Autoimmune disorders often exhibit interconnectedness, although encountering multiple autoimmune conditions in a single patient is uncommon. Multiple autoimmune syndrome is characterized by the presence of at least three distinct autoimmune diseases in an individual. This report outlines the case of a middle-aged woman diagnosed with autoimmune thyroiditis, Sjögren's syndrome, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, and antisynthetase syndrome. Additionally, it includes a literature review encompassing multiple autoimmune syndromes involving five or more autoimmune diseases.
OBSERVATION: A 57-year-old woman, with no previous medical history, presented with fever, extensive muscle weakness, progressive exertional dyspnea, inflammatory polyarthralgia, dysphagia, and dry mouth. Clinical examination revealed muscular deficit in the scapular and pelvic girdles, distal muscular deficit, synovitis in the wrists, and features indicative of "mechanic's hand". Laboratory examinations showed cytolysis, cholestasis, elevated muscle enzymes, hypergammaglobulinemia and elevated thyroid stimulating hormone. Immunoassays showed positive results for antinuclear antibodies, anti-histidyl-t-RNA synthetase, anti-Sjögren's-syndrome-related antigen A, anti-ribonucleic-acid-polymerase-III-RP155, anti-fibrillarin, anti-mitochondrial, anti-liver/kidney microsomal type 1, anti-glycoprotein 210, and anti-thyroid peroxidase antibodies. Further investigations led to the diagnosis of a multiple autoimmune syndrome involving autoimmune thyroiditis, Sjögren's syndrome, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, and antisynthetase syndrome. The patient received treatment with intravenous immunoglobulins, corticosteroids, azathioprine, and ursodeoxycholic acid, which resulted in favorable clinical and biological outcomes.
CONCLUSION: This patient presented with six concurrent distinct autoimmune disorders, categorizing this case as a type two multiple autoimmune syndrome. The identification of antisynthetase syndrome notably distinguishes this case.
Patients undergo moderately intense aerobic/cardiovascular exercise over 30-60 minutes and complete 1-2 sets of 8 to 10 resistance/strength training exercises, 8 to 12 repetitions of each exercise, 3 days per week for 12 weeks. Patients also participate in weekly phone calls with an exercise physiologist to ensure adherence to the program and to provide support.
Provided is an antimalarial dimer immunoadhesin, comprising two dimerization polypeptide chains. The structural general formula of the first polypeptide chain is Z1-Z2. The structural general formula of the second polypeptide chain is Y1-Y2. Z1 is an extracellular domain of a first cell surface receptor, or a functional variant, or a fragment thereof. Z2 is a dimerization domain, or a functional variant, or a fragment thereof. Y1 is an extracellular domain of a second cell surface receptor, or a functional variant, or a fragment thereof. Y2 is a dimerization domain, or a functional variant, or a fragment thereof. The first cell surface receptor and the second cell surface receptor are respectively selected from any one of GYPA, GYPB, GYPC, CR1, and BSG. The dimer immunoadhesin can block the Plasmodium strain from invading the red blood cell and improve the antimalarial effect of the immunocyte.
The invention discloses a polypeptide for inhibiting migration and invasion capacity of oral squamous cell carcinoma and application thereof. The polypeptide has an amino acid sequence shown in SEQ ID NO. 1. In addition, the invention also discloses a pharmaceutical preparation capable of inhibiting migration and invasion capacity of oral squamous cell carcinoma, which consists of the polypeptide and auxiliary materials accepted on the pharmaceutical preparation. The medicinal preparation can be capsules, tablets, injections or sprays and the like. The novel polypeptide disclosed by the invention is proved to have an inhibiting effect on the migration and invasion capacity of oral squamous cell carcinoma by a plurality of experimental techniques such as a cell proliferation experiment, a scratch experiment, a Transwell invasion experiment and the like. The invention provides an effective technical means for treating oral squamous cell carcinoma.
PURPOSE: Presenteeism is defined as the loss of work productivity due to health issues in workers, which can be measured subjectively. This study aimed to compare the effectiveness of supervised exercise therapy and unsupervised self-care in reducing presenteeism in workers with musculoskeletal disorders.
METHODS: PubMed, Embase, and Cochrane Library were searched for various keywords from their inception to January 2023. Two examiners independently assessed the eligibility of studies: (1) studies involving workers suffering from musculoskeletal pain, (2) those involving supervised exercise therapy intervention with interactive communication, and (3) those in which the comparison group was subjected to interventions other than supervised exercise therapy, and (4) those including patient-reported outcome measures of presenteeism or work productivity or ability. Standardized mean differences (SMD) were calculated using a random effects model, with higher scores indicating reduced presenteeism in the intervention group compared with that in the comparison group. The GRADE assesses the overall certainty of the evidence.
RESULTS: Only the short-term effects of interventions on presenteeism could be obtained using four studies. The intervention group showed statistically significant short-term effects on presenteeism compared with the comparison group (p < 0.001; SMD, 0.52; 95% confidence interval, 0.27-0.77). The GRADE score was downgraded by two levels from high to low due to concerns for indirectness.
CONCLUSIONS: Although the certainty of the evidence was low, it was assumed that supervised exercise therapy was more effective than unsupervised self-care in reducing presenteeism in workers with musculoskeletal disorders.
PURPOSE:To improve the workability in the manufacturing extensively and to realize labor saving, rationalization, and the like, by providing the first conveying line, and the second conveying line to convey a container loading table in a closed loop, combining the whole system efficiently by using conveying lines and the like, and automating the whole system. CONSTITUTION:In a conveying line 12, metal moulds 4 are conveyed in order in the direction of the arrows C, and after preheating up to a specific temperature in a preheating device 13, they are conveyed to a filling device 20. Then, after bulk 21 is filled at a specific amount in the patterns 8 of the metal moulds 4, the moulds 4 are conveyed to a cooling device 30 to cool and harden, and the bulk 21 is formed in the patterns 8 as rouge rods 3. On the other hand, cases 2 transferred on a case loading table 68 on the second conveying line 67 by the above transfer device 61 are conveyed to a rouge rod preheating device 70 in the condition the rouge rods are drawn out respectively. Furthermore, they are conveyed to a framing device 71, where gloss and the like are imparted to increase the product value, and then examined at the position of an examination table 81. In such a way, the products are conveyed in order in the direction of the arrow L, and lipsticks 1 can be manufactured in a perfect automation.
Following focus groups at each of the participating sites to assess the feasibility \& needs of each site, the care teams will receive basic training in genomics and how to disclose GS results with VIGOR support. Study orientation will be completed as part of the training. Focus groups will be conducted within 1 year post implementation \& again between year 4 \& the completion of the study, to assess feasibility \& appropriateness of VIGOR. We will administer brief surveys to the care providers before \& after receipt of genomic education to assess their baseline knowledge \& comfort with genomic medicine in newborns. Surveys will be repeated within a week of disclosure to families regarding feedback on the process \& satisfaction with VIGOR. After approximately 3-5 disclosure events, study staff will approach the clinical care team members to participate in a qualitative interview to assess their perspectives in more depth.
FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention proposes a method of synthesis of new 5-substituted pyrrolo[2,3-α]pyrimidines that can be used as semiproducts for synthesis of pyrrolo[2,3-α]- -pyrimidine antitumor agents or antitumor agents. Method of synthesis of the above indicated compounds of the general formula (I)   where R is   or OR′ where R′ - hydrogen or similar or distinct carboxy-protected groups, sign * means L-configuration at carbon atom, n= 0 or 1 and   - aryl group that can be substituted, or their salts involves: a) interaction of 2,4-diamino-6-hydroxypyrimidine with haloidaldehyde of the formula (II)   where Y -bromine, chlorine or iodine atom, and  , R′, R, n and * are indicated above; and b) optionally reaction of salt formation of reactive product of the stage a). Invention describes an additional method of synthesis of compounds of the formula (I). Synthesis is carried out in a single flask. EFFECT: improved method of synthesis. 10 cl, 9 ex
Regarding the advanced stage tumor, especially tumors with large volumes or closely adjacent to organs at risk, patients are not candidates for surgical resection. Therefore, raduitherapy may be the optimal local therapy to ameliorate symptoms and be combined with systemic therapy, including chemotherapy, targeted therapy or immunotherapy. However, for those tumors, ablative doses could not be given due to large volumes and abutting to organs at risk.

In order to solve the problem, spatially fractionated radiation therapy (SFRT) is used. In details, it was performed based on grid or lattice, which creates several cylindrical high-radiation-dose areas in tumors. Nevertheless, the ablative dose areas are limited albeit with SFRT, which may not greatly improve tumor local. Hence, we create an inner and complete inner gross tumor volume that would be delivered ablative radiation doses, which is named as central-boost ablative radiation therapy (CBART). We aim to investigate the efficacy and safety of CBART in large tumors or tumors adjacent to organs at risk.