anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a reactive derivative high in reactive rate, and so even without using catalyst, with little unreacted reactant and useful as cosmetic material by reacting a polysaccharide derivative contg. carboxyl group and soluble in an org. solvent with an epoxy silicone macromer having an alicyclic group on its one end. SOLUTION: As an epoxy silicone macromer having an alicyclic group on its one end, a compd. represented by the formula is used. In the formula, R<1> -R<5> are each substituted or non-substituted 1-10C one valent hydrocarbons, and (n) is 3-20.0. A polysaccharide derivative is dissolved in an org. solvent such as a ketone like acetone, cyclohexanone, or the like, an ether or ester like dioxane, Butyl Cellosolve acetate, or the like, and a silicone macromer is added in an amount not higher than the carboxyl group equivalent and reacted for several hours with heating at 60-200 deg.C under stirring. For the polysaccharide derivative, hydroxypropylmethylcellulose phthalate, and hydroxypropylmethylcellulose acetate succinate are pref.
The present disclosure provides a corona virus killing agent. In particular, the present disclosure provides a corona virus killing agent containing chlorous acid water. In particular, the present disclosure provides a method for killing corona virus, using chlorous acid water. The free chlorine concentration of the chlorous acid water (as Cl = 35.45) may be at least 5 ppm or greater in the absence of organic matter. The content of chlorous acid in the chlorous acid water (as HClO 2  = 68.46) may be at least 200 ppm or greater in the presence of organic matter such as when disinfecting hands/fingers. The corona virus may be SARS corona virus (SARS-CoV), MERS corona virus (MERS-CoV), or the 2019 novel corona virus (SARS-CoV-2).
The invention relates to a compound nutrient tablet for preventing haze damage and a preparation method thereof and belongs to the technical field of healthcare food processing. The compound nutrient tablet is composed of a film coating and a tablet slice, wherein the active ingredients of the tablet slice include broccoli seedling extract, vitamin C, vitamin D, beta-carotene, epigallocatechin gallate, quercetin, filler, binder, collapsing agent and lubricating agent. According to the invention, the raw materials are sterilized, mixed and screened, a dry pressing method is adopted for preparing the tablet, the coating is lastly coated and then the product is dried, so that the end product is acquired. The compound nutrient tablet provided by the invention is rich in various efficient anti-daze active substances, can fully supplement nutrients required by prevention for haze damage and can effectively repair the damage of haze to the organs, including weasand, lung, and the like. The compound nutrient tablet is reasonable in formula and the content of the materials is all within safe scope. After the compound nutrient tablet is long-term taken, the healthcare effects of protecting angiocarpy, promoting immune system function and preventing cancer can be achieved.
PURPOSE:To obtain an agent for transcutaneous administration suitable for the continuous delivery of a systemic drug by adding a systemic drug and fine powder as essential components to a pressure-sensitive tacky adhesive base. CONSTITUTION:A pressure-sensitive tacky adhesive base widely used in general is compounded with a systemic drug (preferably clonidine, estradiol, isosorbitol nitrate, etc.) and fine powder insoluble in the adhesive base, essentially resistant to the impregnation of the drug and having particle size of <=80mum (preferably titanium oxide, silica or aluminum silicate) as essential components. The amount of the fine powder to be compounded to the base is preferably 10-30%. The tacky adhesive to be used in the tacky adhesive base is a thermoplastic elastomer (e.g. styrene-isoprene-styrene block copolymer), an acrylic adhesive, a silicone-based adhesive or a polyisobutylene-based adhesive. The start of the drug release and the adhesiveness to the skin can be improved by using a tacky adhesive layer having a double-layer structure consisting of a powder-containing tacky adhesive layer kept from contact with skin and a powder-free tacky adhesive layer contacting with skin.
Temporomandibular joint (TMJ) arthrocentesis is a widely described and effective technique that promotes lysis and lavage of TMJ compartments, improving pain and mandibular range of motion. Mostly, this technique has been used to reach the upper TMJ compartment, besides effusion may be present also in lower compartment, that, in the absence of disc perforation, may also need to be assessed. Here, we propose an adaptation of arthrocentesis technique aiming to access both upper and lower compartments of the TMJ with a single needle puncture and guided by ultrasound real-time images. The technique was initially established in fresh cadavers and later replicated in 2 patients. Technique modification proved to be efficient and reproducible, reducing the number of perforations and, consequently, possible adverse events. The proposed technique can be applied to arthrocentesis and/or intra-articular injections through the combination of two previously validated techniques, to improve its safety and efficacy.
BACKGROUND: Acute retinal pigment epitheliitis (ARPE) is a rare, idiopathic and self-limiting disease. The article aims to present ARPE in a patient using D2 dopamine receptor agonists for the treatment of hyperprolactinemia.
CASE PRESENTATION: A 28-year-old female during hyperprolactinaemia treatment suffered from a dyschromatopsia and a central visual field defect in the left eye. She noticed a deterioration of vision and discontinued the cabergoline administration. The woman had not been diagnosed with other chronic conditions and exhibited no symptoms of infection. Upon admission, the patient was subjected to a test for COVID-19, which was negative. The ophthalmological examination revealed a decrease in visual acuity to distance in the left eye, which amounted to 18/20 on the Snellen chart. A central scotoma was noted on the Amsler chart and a loss of pigment epithelium was visible on the fundus of the left eye. Fluorescein angiography showed a discrete window defect in the left one, with no signs of leakage. Optical coherence tomography (OCT) scans of the maculae revealed a characteristic change in the photoreceptor layer and retinal pigment epithelium (RPE) in the fovea in the left eye. The electrophysiological tests revealed decreased function of cells in macular region. A magnetic resonance imaging (MRI) of the head and orbits demonstrated an asymmetric pituitary gland without chiasm compression and discrete signal enhancement from the left optic nerve. The patient underwent observation during hospitalisation. She reported improved colour vision and a decreased scotoma in the centre of her visual field. In regular outpatient follow-ups, successive improvements in visual acuity, as well as a decreased RPE damage and outer photoreceptor layer loss during an OCT test were observed.
CONCLUSIONS: A case of ARPE is reported in a patient taking medications for hyperprolactinemia. The role of dopamine receptor antagonists in the photoreceptor function and causation of ARPE needs further evaluation.
BACKGROUND/AIMS: The pathophysiology of lean nonalcoholic fatty liver disease (NAFLD) is unclear but has been shown to be associated with more diverse pathogenic mechanisms than that of obese NAFLD. We investigated the characteristics of genetic or metabolic lean NAFLD in a health checkup cohort.
METHODS: This retrospective cross-sectional study analyzed single nucleotide polymorphism data for 6,939 health examinees. Lean individuals were categorized according to a body mass index cutoff of 23 kg/m2. Single nucleotide polymorphisms were analyzed using genotyping arrays.
RESULTS: The prevalence of lean NAFLD was 21.6% among all participants with NAFLD, and the proportion of lean NAFLD was 18.5% among lean participants. The prevalence of metabolic syndrome and diabetes among lean patients with NAFLD was 12.4% and 10.4%, respectively. Lean NAFLD appeared to be metabolic-associated in approximately 20.1% of patients. The homozygous minor allele (GG) of PNPLA3 (rs738409) and heterozygous minor alleles (CT, TT) of TM6SF2 (rs58542926) were associated with lean NAFLD. However, the prevalence of fatty liver was not associated with the genetic variants MBOAT7 (rs641738), HSD17B13 (rs72613567), MARC1 (rs2642438), or AGXT2 (rs2291702) in lean individuals. Lean NAFLD appeared to be associated with PNPLA3 or TM6SF2 genetic variation in approximately 32.1% of cases. Multivariate risk factor analysis showed that metabolic risk factors, genetic risk variants, and waist circumference were independent risk factors for lean NAFLD.
CONCLUSIONS: In a considerable number of patients, lean NAFLD did not appear to be associated with known genetic or metabolic risk factors. Further studies are required to investigate additional risk factors and gain a more comprehensive understanding of lean NAFLD.
The invention relates to the synthesis of polyoxygenated nitrogen systems, comprising reactions between enamines of 1,3-dioxan-5-ones and nitroolefins. More specifically, the invention relates to the reaction between enamines having formula II which are derived from 1,3-dioxan-5-ones I and nitroolefins having formula III. In this way, novel polyoxygenated nitrogen systems are generated having formula IV and V, which, as they are or following simple transformations, constitute synthetic intermediates and/or analogues of different systems of proven biological/pharmacological interest, such as certain antibiotics, or tetrodotoxin, pancratistatin or the analogues thereof. The aforementioned reactions involve the use of enamines II in Michael-type addition reactions and in direct annealing processes with double acceptor systems at relative positions 1, 3. Said N acceptors include nitroolefins III, wherein R═CHO (alphanitroenals). The invention also relates to the preparation thereof, which is based on the oxidation of the corresponding precursor alcohols VII, and the use of same in annealing processes.
The invention provides an application of cimicifuga rhizome glycoside in preparing a medicine for preventing and treating atopic dermatitis, belonging to the technical field of medicines. The research of the invention proves that the cimicifuga rhizome glycoside has high safety for treating atopic dermatitis. Animal experiments show that the cimicifuga rhizome glycoside can obviously improve the skin damage severity of a calcipotriol-induced atopic dermatitis mouse model, reduce the EASI score, lighten the auricle and epidermis thickness and reduce the dermal lymphocyte infiltration degree. Cimicifuga glucoside can significantly down regulate expression of in vitro and in vivo models of atopic dermatitis, IL-4, IL-5, IL-13 and Tslp mRNA, and reduces expression of CD3 and NF- κBp50 positive cells of atopic dermatitis mice. In vitro and in vivo experiments show that cimicifuga rhizome glycoside has inhibiting effect on Th2 cell mediated atopic dermatitis. Therefore, the cimicifuga rhizome glycoside is hopeful to be a clinical medicine for safely and effectively preventing and treating atopic dermatitis.
A patient coordination system, method and software product receives configuration of a hospital within a server. A hospital model is determined based upon the configuration. Location of each patient within the hospital is received. A course through hospital for each patient is received. Status for each patient is received from independently run hospital services. Progress of each patient through the corresponding course is determined and a dashboard showing the hospital model with spatial indication of the progress for each patient is generated.
FIELD: biotechnology, medicine, immunology. SUBSTANCE: polyvalent vaccine used for immunoprophylaxis and immunotherapy of diseases caused by opportunistic microorganisms comprises a mixture of antigens isolated from strains Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli and Staphylococcus aureus. Vaccine comprises lipopolysaccharide associated with external membrane protein as antigen from Klebsiella pneumoniae, proteoglycan of chemical composition: 10.0-20.0% of protein, 30.0-40.0% of carbohydrates and molecular mass above 20 000 Da. Vaccine comprises lipopolysaccharide associated with external membrane protein as antigen from Proteus vulgaris of chemical composition: 40.0-60.0% of protein, 25.0-35.0% of carbohydrates and molecular mass above 20 000 Da. Vaccine comprises lipopolysaccharide associated with external membrane protein as antigen from Escherichia coli of chemical composition: 16.0-20.0% of protein, 15.0-30.0% of carbohydrate and molecular mass above 20 000 Da. Vaccine comprises antigen of cellular wall as an antigen from Staphylococcus aureus containing teichoic acid, peptidoglycan and labile proteins of chemical composition: 13.0-21.0% of protein, 8.0-16.0% of carbohydrates and molecular mass above 20 000 Da. Antigens of indicated strains are taken in the following ratio: 1: 1: 1:1.2 g, respectively, by dry weight per 1 l of vaccine. Concentrating and purification of antigens are carried out by ultrafiltration and diafiltration. Vaccine shows high immunogenicity and stability. EFFECT: improved preparing method, valuable medicinal properties of vaccine. 2 tbl, 1 ex
BACKGROUND: Cough variant asthma (CVA) is one of the most common causes of chronic cough in children worldwide. The diagnosis of CVA in children remains challenging. This study aimed to assess the diagnostic utility of impulse oscillometry (IOS) pulmonary function in children with CVA.
METHODS: This study included children aged 4 to 12 years diagnosed with CVA who underwent IOS pulmonary function and bronchodilation (BD) tests. A control group of healthy children was matched. Pre- and post-BD IOS parameters were recorded and presented as mean ± standard deviation or median. Receiver operating characteristic (ROC) curves were plotted, and the area under the curve (AUC) was calculated to evaluate the discriminatory potential of the IOS parameters for diagnosing CVA.
RESULTS: A total of 180 patients with CVA and 65 control subjects were included. The baseline IOS parameters in the CVA group, except X5%pred, were significantly greater compared to the control group. After inhalation of salbutamol sulfate, all IOS parameters improved significantly in the CVA group. However, Z5%pred, R5%pred, and R20%pred remained greater in the CVA group compared to the control group. The improvement rates of IOS parameters in the CVA group significantly surpassed those in the control group. The ROC curve results for pre-BD IOS parameters and the improvement rate during the BD test showed that the combinations of pre-Z5%pred+△Z5% and pre-R5%pred+△R5% achieved the highest AUC value of 0.920 and 0.898, respectively. The AUC values of these combined parameters surpassed those of individual ones.
CONCLUSIONS: This study highlights that children with CVA exhibit greater IOS parameters compared to healthy children. The changes in IOS parameters during the BD test provided valuable diagnostic information for CVA, and the combination of various parameters can help pediatricians accurately identify CVA in children.
Girls with Turner Syndrome, between the ages of 10-16 years, were chosen as the study population. The study requires 3 overnight admissions to an in-patient Clinical Research Center(CRC). A baseline study is performed using stable isotope tracers of leucine, glycerol and glucose and serial blood sampling to measure protein and fat metabolism. Indirect calorimetry is used to measure substrate oxidation rates and total energy expenditure. DEXA scan is used to measure bone mineral density and body composition. Once the baseline study is complete subjects are randomly assigned to receive either estrogen orally or through a patch placed onto the skin in increasing doses changed every 2 weeks. After 6 weeks of estrogen treatment a second metabolic study, identical to the first, is performed, followed by a wash out period of 4 weeks. Subsequently, the subjects are switched to the alternate form of estrogen. At the end of 6 weeks a third and final metabolic study is repeated. All subjects continue to be on growth hormone throughout the study procedures.
The reliability and validity of the scale will begin with language equivalence and cultural adaptation. The scale will be translated from English to Turkish by two people who are fluent in Turkish and English. A single Turkish translation will be obtained from these two Turkish translations with a common opinion. The scale, which has been translated into Turkish, will be translated into English by two other people who are fluent in Turkish and English. The scale translated into English will be compared with the original. If the developer of the scale, miguel blacutt and Stults-Kolehmainen approves the translation of the scale, participants will be recruited for the study. In the pre-trial phase, a pre- assessment will be conducted with 15 participants to test the intelligibility of the scale. Based on the results of the pre-test phase, the final version of Exercise Sensitivity Questionnaire will be able to be modified. Exercise Sensitivity Questionnaire scale questions and questions in the data collection form face to face 450 participants will be included in the study. In order to evaluate the validity of the Exercise Sensitivity Questionnaire.Tampa Kinesiophobia- Heart and Tampa Kinesiophobia has been validated in Turkish, will be used. Scales will be repeated after 15 days to assess test-retest reliability.
PROBLEM TO BE SOLVED: To provide a luminous cream which applies on a contracting/expanding article by mixing a luminous phosphor with cream agent. SOLUTION: A luminous phosphor is mixed with cream agent composed of extremely thick emulsion so as to form luminous cream. Petroleum, aqueous solution such as fluoreselen, canary glass, solid such as platinum cyanide, and sulfide in alkali earth metals, etc., are used for this light storage phosphor. Organic and inorganic fluorescent pigment can be also used. This luminous cream is used for a contracting/expanding article such as a condom so that rubber films are prevented from closely sticking to each other in manufacturing or storing and the feeling of the physical disorder due to friction can be reduced in using. One which is lost its function and safety required for the cream and the one which reduces the light emission power by mixing are not adopted as the cream used for the condom.
BACKGROUND: It has long been observed that there are families in which non-medullary thyroid cancer (NMTC) occurs, but few syndromes and genes have been described to date. Proteins in the shelterin complex have been implied in cancer. Here, we have studied shelterin genes in families affected by NMTC (FNMTC).
METHODS: We performed whole-exome sequencing (WES) in 10 affected individuals from four families with at least three affected members. Polymerase chain reaction (PCR) and Sanger sequencing were performed to search for variants in the TINF2 gene in 40 FNMTC families. TINF2 transcripts and loss of heterozygosity (LOH) were studied in several affected patients of one family.
RESULTS: We found the c.507G>T variant in heterozygosis in the TINF2 gene in one family, co-segregating in all five affected members. This variant affects the normal splicing. LOH was not observed.
CONCLUSIONS: Our results reinforce the TINF2 gene as a susceptibility cause of FNMTC suggesting the importance of location of frameshift variants in TINF2. According to our data and previous literature, TINF2 pathogenic variants appear to be a significant risk factor for the development of NMTC and/or melanoma.
Norepinephrine infusion . applying norepinephrine infusion 0.5 mg norepinephrine added to 50 ml Normal Saline and set it to run with 0.05 mg/kg/min.
A computer-implemented method, a computer system and a computer program product manage a medical treatment of a care recipient. The method includes obtaining a treatment record for the care recipient from a server. The method also includes capturing real-time biometric data of the care recipient using a plurality of sensors. The method further includes determining a severity level of the adverse event by comparing the real-time biometric data with the treatment record in response to detecting an adverse event in the real-time biometric data. In addition, the method includes generating a recommendation for an alternative treatment in response to the severity level being above a threshold. Lastly, the method includes transmitting a notification comprising the recommendation to a treatment provider.
Meningiomas are predominantly benign tumors, but there are also malignant forms that are associated with a poor prognosis. Like almost all tumors, meningiomas metabolize glucose as part of aerobic glycolysis (Warburg effect) for energy supply, so there are attempts to influence the prognosis of tumor diseases using a glucose-reduced diet. This altered metabolism leads to so called hallmarks of cancer, such as glycation and glycosylation. In this study, we investigated the influence of low (3 mM), normal (5.5 mM) and high glucose (15 mM) on a malignant meningioma cell line (IOMM-Lee, WHO grade 3). In addition, the influence of methylglyoxal, a by-product of glycolysis and a precursor for glycation, was investigated. Impedance-based methods (ECIS and RTCA) were used to study migration and invasion, and immunoblotting was used to analyze the expression of proteins relevant to these processes, such as focal adhesion kinase (FAK), merlin or integrin ß1. We were able to show that low glucose reduced the invasive potential of the cells, which was associated with a reduced amount of sialic acid. Under high glucose, barrier function was impaired and adhesion decreased, which correlated with a decreased expression of FAK.
A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously provisionally named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) emerged at December 2019 in Wuhan, Hubei Province, China. This infectious disease soon caused a large global outbreak and became a major public health issue. As of 19:00, 12 March 2020, the total number of confirmed cases of SARS-CoV-2 in China has reached 80982 with 3173 death, and 110 other countries have officially reported 45164 cases of SARS-CoV-2 infection with 1520 death.

In this particular time, only patients with SARS-CoV-2 or other diseases with an emergency condition were receipted by most of the hospitals in Hubei Province, even in many other regions of China. The delayed treatment for many chronic diseases, such as malignant tumors, is an increasing serious problem. One major concern was that patients with malignant tumors were generally older in age with low immunity. Preliminary study has shown that cancer patients are most susceptible to infect SARS-CoV-2 and more likely to develop a severe pneumonia. But many other researches suspected that conclusion. Moreover, many of the patients with malignant tumors are facing short term death from tumors rather than the risk of infection. Nevertheless, there is not sufficient evidence to insure the safety of chemotherapy in high-risk region of COVID-19, and there is also not sufficient information to judge which patients' tumor therapy can be appropriately delayed. Here the investigators investigate the safety of chemotherapy for patients with gynecological malignancy in Wuhan, the center of high-risk regions of COVID-19.