anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides an azelaic acid oligopeptide preparation with effects of efficiently preventing and treating acnes and an application thereof in medical cosmetic. The preparation is synthesized from azelaic acid and oligopeptide under the effect of a catalyst. The azelaic acid oligopeptide synthesized by the invention has the characteristics of being good in water solubility, and significant in effect of preventing and treating acnes, low in side effect and the like. The cosmetic containing azelaic acid oligopeptide prepared by the preparation can be the dosage forms such as stoste, water aqua, facial mask, cream dew, liquid makeup, hair gel, essence and the like. The cosmetic is compounded by the azelaic acid oligopeptide and matrix. A lot of clinical tests prove that the medical cosmetic disclosed by the invention has the characteristics of being good in prevention and treatment of the acnes on the skin of a human body, good in nutrient, small in side effect and the like.
A blood test for Prostate Specific Antigen (PSA) will then be performed. Subsequently, for subjects with serum PSA 4-10 ng/ml, additional blood tests for Prostate Health Index (PHI) will be performed for the further assessment of risk of prostate cancer. Subjects with serum PSA \> 10 ng/ml; or PHI ≥ 35 will be referred for Trans-rectal Ultrasound-guided Prostatic Biopsy (TRUS+PB). Subjects with serum PSA \< 4 ng/ml or with PHI level \< 35 will be invited to repeat the prostate screening tests every 2-years. We aim to screen not more than 5,000 subjects. For all patients recruited for prostate cancer screening, the study team will continue follow the subjects, by phone or mail or other means, for the long term clinical outcome for up to 10 years.
The invention discloses a preparation method of a traditional Tibetan medicine for treating cerebral thrombosis. The cerebral thrombosis comprises an active component or an active component and medically acceptable auxiliary materials, wherein the active component is prepared by pearl, gastrodia elata, corydalis impatiens, phyllanthus emblica, bear bile powder and agilawood in a certain weight proportion. The traditional Tibetan medicine can be prepared into powders. The traditional Tibetan medicine has the functions of promoting circulation and removing stasis and resisting thromb and flowing venation. Traditional Tibetan medicine is applied to treating cerebrovascular disease due to 'dragon'. Traditional Chinese medicine is applied to treating cerebral thrombosis, myocardial infarction, thrombophlebitis, and thromboangitis obliterans.
UDP-glucuronosyltransferases (UGT) Inducers   
Concomitant use of UGT inducers decreases systemic exposure. Avoid the concomitant use of strong UGT inducers (e.g., rifampicin, phenytoin, phenobarbital, ritonavir) . If you must administer deferasirox tablets with a Strong UGT inducer, consider increasing the initial dose by 50%, and monitor serum ferritin levels and clinical responses for further dose modification [ see Dosage and Administration (2.1,2.2),Drug Interactions (7.5)].   
Bile Acid Sequestrants   
Concomitant use of bile acid sequestrants decreases systemic exposure. Avoid the concomitant use of bile acid sequestrants (e.g., cholestyramine, colesevelam, colestipol). If you must administer deferasirox tablets with a bile acid sequestrant, consider increasing the initial dose by 50%, and monitor serum ferritin levels and clinical responses for further dose modification [ see Dosage and Administration (2.1,2.2) Drug Interactions (7.6)].
Participants 6 to \<12 years of age received a single intravenous infusion of tedizolid phosphate dosed at 5 mg/kg of total body weight. Maximum dose is 200 mg of tedizolid phosphate.
Polysaccharides are one of the main active ingredients of Polygonum sibiricum (PS), which is a food and medicine homolog used throughout Chinese history. The antidepressant-like effects of PSP and its underlying mechanisms remain elusive, especially the regulation of microglial polarization. The current study determined the chemical composition and structural characteristics of PSP. Then, the chronic unpredictable mild stress (CUMS) procedure was carried out on the zebrafish for 5 weeks, and PSP was immersed for 9 days (1 h/d). The body weight of zebrafish was monitored, and behavioral tests, including the novel tank test and light and dark tank test, were performed to evaluate the antidepressant-like effects of PSP. Then, the function of the hypothalamic-pituitary-interrenal (HPI) axis, the levels of peripheral inflammation, neuronal and blood-brain barrier damage in the mesencephalon and telencephalon, and the mRNA expression of M1/M2 phenotype genes in the brain were examined. PSP samples had the typical structural characteristics of polysaccharides, consisting of glucose, mannose, and galactose, with an average Mw of 20.48 kDa, which presented porous and agglomerated morphologies. Compared with untreated zebrafish, the depression-like behaviors of CUMS-induced zebrafish were significantly attenuated. PSP significantly decreased the levels of cortisol and pro-inflammatory cytokines and increased the levels of the anti-inflammatory cytokines in the body of CUMS-induced depressive zebrafish. Furthermore, PSP remarkably reversed the neuronal and blood-brain barrier damage in the mesencephalon and telencephalon and the mRNA expression of M1/M2 phenotype genes in the brain. These findings indicated that the antidepressant-like effects of PSP were related to altering the HPI axis hyperactivation, suppressing peripheral inflammation, inhibiting neuroinflammation induced by microglia hyperactivation, and modulating microglial M1/M2 polarization. The current study provides the foundations for future examinations of PSP in the functional foods of emotional regulation.
Participants, following exercise-induced hyperthermia, will be cooled using cold water immersion. Participants will be immersed up to their chest in cold water (\~50-55 Degrees Fahrenheit).
PURPOSE: A peptide with antibiotic function and a gene encoding the same are provided to effectively suppress bacteria and fungi. CONSTITUTION: An antifungal peptide has an amino acid sequence derived from Eumenes pomiformis poisonous liquid. The peptide has a structure of bipolar alpha-helix form. The antifungal peptide has an amino acid sequence of sequence number 2. A C-terminal leucine residue in an amino acid sequence of sequence number 4 is denoted by FDLLGLVKKVASAL-NH2. A C-terminal leucine residue in an amino acid sequence of sequence number 6 is denoted by FDLLGLVKSVVSAL-NH2. An antifungal composition contains the antifungal peptides as an active ingredient.
The invention discloses a fenugreek extract for improving dental ulcer, and a preparation method and application thereof. The experimental results show that: the fenugreek extract can effectively lighten the degree of pathological injury of the oral cavity of the mouse and promote the healing speed of the mouse. The single fenugreek ethanol extract can achieve the effect of improving dental ulcer, which is equivalent to that of a positive medicine. Meanwhile, the fenugreek extract prepared by the invention can also reduce the content of IL-6, IL-alpha, CXCL1 and GM-CSF in the serum of mice; reduce the gene expression level of TNF-alpha and IL-1 beta in ulcer tissues and promote the gene expression level of TGF-beta 1 and MMP-9. The invention exploits a new medical application of the fenugreek ethanol extract. The fenugreek is safe and nontoxic, has strong pharmacological action, is rich in sources, low in cost and mature in preparation process, can be prepared into various oral dosage forms, and is convenient to use. Has positive significance for research and development of inflammatory canker sore medicaments or health-care foods.
PURPOSE: A composition containing Arthraxon hispidus extract for preventing and treating inflammatory diseases is provided to suppress NO and leukotriene activity. CONSTITUTION: A composition for preventing and treating inflammatory diseases contains Arthraxon hispidus extract as an active ingredient. The Arthraxon hispidus extract is obtained using water, low alcohol of C1-C4, or mixture solvent thereof. The composition also contains organic solvent fraction obtained by extracting with organic solvent from the Arthraxon hispidus extract. The organic solvent is hexane, ethyl acetate, or butanol. A health food for preventing and treating inflammatory diseases contains the Arthraxon hispidus extract, fraction thereof, or active fraction isolated from the fraction as an active ingredient.
High blood pressure is a very common problem in patients with kidney disease. Researchers have noted that there are certain molecules in the blood of these patients that may be contributing to the high blood pressure. In particular these molecules have been labeled as "digoxin-like substances." Digoxin is a drug made from a certain plant that may contribute to high blood pressure. In research animals with kidney failure, it has been noted that the use of Digibind helps to lower the blood pressure in these animals. Digibind is a drug made from sheep that is used to treat the toxicity from digoxin as well as toxicity from molecules similar to digoxin.

In this study, volunteers that are on hemodialysis and have high blood pressure will be given a placebo or the digibind drug intravenously on two separate visits. The volunteers will then wear a 24-hour blood pressure monitor and return the following day. Volunteers will receive the Digibind at one visit during the study, and the placebo on the other visit.
The subjects in the study group will undergo a series of 4 treatments by 2 certified physiotherapists for pelvic floor treatment that will include instruction in self-use of anal dilators once a week for four weeks. The anal dilation will be performed using Dilatan® anal dilators (Enterprises Sapimed, Alessandria) in varying sizes of 22, 23 and 27 mm. In the first week, a 20 mm dilator will be inserted twice a day for at least 10 minutes. In the second week, a 23 mm extender will be inserted into the anus, twice a day for at least 10 minutes. In the last two weeks, a 27 mm extender will be inserted twice a day for at least 10 minutes. To facilitate the insertion of the extender, patients will use lubricating cream. At the end of each week, patients will meet with a pelvic floor physiotherapist to make sure that the insertion is done properly, that there are no side effects and that it is possible to move on to the next step.
Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.
Hereditary non-polyposis colorectal cancer (HNPCC) is associated with up to an 80% lifetime risk of developing colorectal cancer and a 40-50% chance of a metachronous tumor after partial colectomy for the disease. For these patients, prophylactic colectomy has been proposed as a potential risk management alternative to a lifetime of intensive surveillance by colonoscopy. The highly personal nature of such risk management decisions has been recognized in the development of individualized genetic counseling services. However, prior psychosocial research in this area has tended to use linear statistical techniques in which clinically important details are lost in an overly broad, one size-fits-all model that is difficult to apply in a one-to-one counseling session. We propose an innovative approach based on the Cognitive-Social Health Information Processing (C-SHIP) model in which we will explore how attitudes towards prophylactic colectomy are organized into meaningful patterns or types that can translate readily into tailored counseling recommendations. Specific aims of this study are: 1)to assess levels of intention in prophylactic colectomy among HNPCC patients; 2)To identify distinctive decision types based on profiles of perceived pros and cons of prophylactic colectomy; and 3) To explore the pattern of relations between decision types and counseling-related outcomes (level of intention in colectomy, cancer-specific anxiety, and colonoscopy adherence). We will conduct a one-time cross-sectional telephone survey of 320 HNPCC patients (defined as either carriers of a mutated mismatch repair gene associated with HNPCC or those with a personal/family history meeting published criteria for HNPCC). Using cluster analysis we will create a taxonomy of decision types. Prior research leads us to expect at least three types: Disengaged, Risk-Focused, and Ambivalent. We hypothesize that each type will have a different pattern of relations with the outcome variables (e.g., Risk-focused types will show higher level of intention regarding surgery, high anxiety, low avoidance, and high colonoscopy adherence, whereas Ambivalent types will show higher level of intention regarding surgery, high anxiety, high avoidance, and low colonoscopy adherence). Understanding these patterns will enhance the ability of physicians, genetic counselors, and other providers to help their patients make well informed, thoughtful decisions about the preventive strategy that will best protect their health, emotional well-being, and quality of life.
Participants were non-smoking, healthy, but overweight/obese men and women with no known cardiovascular or metabolic diseases as assessed by a medical history and a comprehensive medical examination by their physicians. All participants were sedentary or lightly active (\<30 min, 2d/wk of structured physical activity) as assessed by a Physical Activity questionnaire, overweight or obese (BMI\>27.5 kg/m2; % body fat\>30%), middle aged (30-65 years), and weight stable (+/-2kg) for at least 6 months prior to beginning the study. Individuals with a history of cardiometabolic disease (e.g. diabetes, heart disease, etc) and/or cancer and presently taking medications for these conditions, who are pregnant or may be pregnant, are allergic to milk products or are anorexic or bulimic were excluded from participation. Each participant provided informed written consent in adherence with the Skidmore College Human Subjects review board prior to participation and the study was approved by the Human Subjects Institutional Review Board of Skidmore College. All experimental procedures were performed in accordance with the Federal Wide Assurance and related New York State regulations, which are consistent with the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research and in agreement with the Helsinki Declaration as revised in 1983.
Healthy volunteer subject cohorts randomized 6:2 receiving a single dose of FT-4202 or placebo. The first cohort will receive 200 mg of FT-4202 or placebo. Dose escalation will occur if FT-4202 or placebo is tolerated. The maximum dose of FT-4202 or placebo will be 1500 mg.
The invention discloses a formula of Hui nationality traditional Chinese medicine six-ingredient particles for treating leukemia and a preparation method of the Hui nationality traditional Chinese medicine six-ingredient particles. The Hui nationality traditional Chinese medicine six-ingredient particles are eco-friendly high-tech traditional Chinese medicines for treating leukemia and are prepared from traditional Chinese medicines such as herb of glabrous sarcandra, radix sophorae tonkinensis, pseudobulbus cremastrae seu pleiones, isatis root and the like according to a certain proportion through material blending, water decoction, extraction, concentration and granulation. The Hui nationality traditional Chinese medicine six-ingredient particles are mainly used for treating leukemia and also can treat digestive system cancers such as pharyngolaryngeal cancer, gastric cancer and colorectal cancer. The Hui nationality traditional Chinese medicine six-ingredient particles have a moderate taste and a moderate dose. The selected traditional Chinese medicines are proved to be able to treat cancers by the modern medical pharmacology experiments. The Hui nationality traditional Chinese medicine six-ingredient particles realizes a very low cost, can thoroughly improve body functions, can prevent disease deterioration and can restore body health.
Two types of brief intervention, Brief Advice (BA) and Motivational Interviewing (MI), have been shown to be efficacious in reducing drinking in non-HIV samples. Our goal is to determine whether offering counseling beyond Brief Advice, namely MI, has greater alcohol reduction effects. In the proposed randomized trial, all 300 HIV-HCV co-infected participants will receive BA delivered by their HIV PCP during a regular HIV visit and will then be randomized to either a 30-minute Motivational Interviewing Intervention with a Behavioral Counselor (MI) or to HIV clinic treatment-as-usual. After this initial meeting, drinking "check-in" (MI or BA) sessions will then be provided telephonically every three months for 18 months. Research assessments will also be done every three months, with a final assessment at 24 months. Our primary outcome is drinks per week.
A system and method for an adjustable bio-stream self-selecting system. Through a plethora of inputs, the system associates therapeutic recipes and associated biomarker in a personalized approach to recommending an individual to a specific therapeutic program. Therapeutic programs operate in accordance with personalized inputs suggested by the user and through digital markers and biomarkers, which trigger new recommendations by “knowing” the individual. Each bio-stream contains information utilized within these biomarkers to trigger additional therapy recommendations. Because of the complexity of the plurality of inputs, these biomarkers are managed in a way that enables low latency detections, low bandwidth needs, low processing needs, and less battery needs. The pre-processing of these biomarkers helps additional therapy management and precision medicine across larger global population needs of the system.
Aim: Endotracheal intubation increased the heart rate and blood pressure in normal patients. Open heart surgery patients are more prone to hemodynamic variability. In addition, they have increased possibility for difficult intubation The heart rate and blood pressure increase impaired the oxygen consumption. This was previously shown that Videolaryngoscopes minimaly effects the vital signs in normal patients. Videolaryngoscopy inreased the rate of success in normal and difficult airway. This study aimed to compare two laryngoscopes regarding hemodynamic parameters and intubation times in coronary bypass surgery.

Material and methods: 50 patients undergoing coronary bypass surgery enrolled in this prospective.randomized study. Demogaphic variables and airway characteristics of patients were recorded. Glottic visulisation and intubation time were recorded. Systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate were recorded 2 minutes intervals before intubation, after intubation during 10 minutes.
The estrogenic properties of glabridin, the major isoflavan in licorice root, were tested in view of the resemblance of its structure and lipophilicity to those of estradiol. The results indicate that glabridin is a phytoestrogen, binding to the human estrogen receptor and stimulating creatine kinase activity in rat uterus, epiphyseal cartilage, diaphyseal bone, aorta, and left ventricle of the heart. The stimulatory effects of 2.5-25 mg/animal glabridin were similar to those of 5 mg/animal estradiol. Chemical modification of glabridin showed that the position of the hydroxyl groups has a significant role in binding to the human estrogen receptor and in proliferation-inducing activity. Glabridin was found to be three to four times more active than 2\*-O-methylglabridin and 4\*-O-methylglabridin, and both derivatives were more active than 2\*,4\*- O-methylglabridin. The effect of increasing concentrations of glabridin on the growth of breast tumor cells was biphasic. Glabridin showed an estrogen receptor-dependent, growth-promoting effect at low concentrations (10 nM-10 mM) and estrogen receptor-independent antiproliferative activity at concentrations of \>15 mM. This is the first study to indicate that isoflavans have estrogen-like activities. Glabridin and its derivatives exhibited varying degrees of estrogen receptor agonism in different tests and demonstrated growth-inhibitory actions on breast cancer cells.
A composition composed of an inorganic carrier material of the formula 4 MeO. X2O3.n aq WHEREIN Me is an alkaline earth metal, X is trivalent iron or aluminum, AQ IS WATER OF CRYSTALLIZATION, AND N IS AT LEAST 7, HAVING ADSORBED THERETO OR INCLUDED IN ITS CRYSTAL LATTICE A POLAR ORGANIC COMPOUND OR A NONPOLAR ORGANIC COMPOUND AND A POLAR ORGANIC COMPOUND. Said carrier material may contain anions such as SO4 2, CO3 2, or Cl and may be alkylated. The resulting adsorption complex, inclusion or clathrate compound is stable, of a high degree of crystalline orderliness, and uniform in its physical and chemical properties. It is prepared by contacting the inorganic carrier material with the liquid or gaseous organic compound or with its solution. It is also obtained by adding the organic compound during preparation of the inorganic carrier material. The adsorption complexes, inclusion or clathrate compounds are useful for modifying cement and concrete, for storing insecticides, perfumes, drugs, dyes etc. to be released at the site of their use, and for many other technical purposes. The inorganic carrier material is obtained, for instance, by reacting mono-or tricalcium aluminate or tetracalcium aluminate ferrite with water or calcium hydroxide suspensions or by reacting alkali aluminate solutions with the oxides or hydroxides of calcium or magnesium.
<P>PROBLEM TO BE SOLVED: To provide an eye washer capable of eliminating the need of repeatedly using a cup to prevent contamination of germs and attain a high safety, and dispensing with an antisepic agent mixed so as to be low-irradiating to the eye.  <P>SOLUTION: In this eye washer, an eye washing lotion at least containing drug is put in a unit dose type eye washing cup, and a film-like lid part is provided. Preferably, the drug is at least one kind of a resolution and astringent, antihistamine, vitamins and amino acids, or it contains trometamol. The eye washing cup is formed of flexible raw material whose light transmittance is 10% or lower at a wavelength ranging from 200 nm to 380 nm. The lid part includes a laminate of a resin sheet layer and an aluminum sheet layer.  <P>COPYRIGHT: (C)2003,JPO
Subjects with eGFR above 125 ml/min per 1.73 m2 will be randomized to dapagliflozin, 5 mg/day. After 2 weeks (Visit 5), dapagliflozin will be increased to 10 mg/day, Subjects who are taking Metformin at time of randomization will have Dapagliflozin added to current metformin.
Disclosed are a cell penetrating peptide, a conjugate which is an active ingredient, and a use of same. More specifically, disclosed are the cell penetrating peptide having one sequence from among SEQ ID NO. 1 to SEQ ID NO. 6, a conjugate comprising a peptide that is a fragment of one sequence from SEQ ID NO. 1 to SEQ ID NO. 6 or a peptide having a sequence that is at least 80% homologous with the peptide sequence, and a composition comprising the conjugate.