anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Circumcision, which is performed on an outpatient basis is commonly a short durational operation in boys. Postoperative pain and agitation are the most common complaints in children with circumcision. The most important factor affecting the length of hospital stay is to provide an effective analgesia. Various methods are being used to manage postoperative pain such as caudal block, penile block, topical analgesia or intra-venous (iv) analgesics. Caudal block is applicable widely in pediatric day case surgery, providing excellent postoperative analgesia and attenuation of the stress response in children. Opioids can cause several side effects such as respiratory depression, suppression of bowel movements, nausea, vomiting, itching, addiction. Opioid drugs are not recommended in children as well. Lower abdominal surgeries affect dermatomes T10-L1 and blocking these nerve roots provides effective postoperative analgesia. Neuraxial blocks such as epidural and caudal blocks is considered the gold standard regional technique for pain management after lower abdominal surgery, blocking both somatic and visceral pain. Recent studies suggest that lidocaine and bupivacaine can be used in combination or a sole agent when performing regional anesthesia in children. But it remains unknown whether these combinations are useful or simply reflect underlying status. There is no report comparing the effects of bupivacaine alone and in combination with lidocaine at performing caudal epidural block in children. The investigators thus tested the primary hypothesis that combining the two different local anesthetics has a synergistic analgesic effect and can accelerate the onset time and decrease the need for additional analgesic doses. Secondarily, the investigators tested the hypothesis that providing intra-operative and postoperative analgesia reduces the risk of hemodynamic deteriorations, length of hospital stay, first micturition and mobilization times, surgical and anesthetic complications.
Patients receive deslorelin, estradiol, and testosterone intranasally QD for 6 months. Patients then undergo planned risk reduction mastectomy.
Subjects will remain in this arm for 6 months before being crossed-over. The pacemaker will be programmed to VVI 30 bpm. Dynamic AV delay will be programmed off throughout the study.
Chronic obstructive pulmonary disease is a type of chronic bronchitis and (or) emphysema having the characteristic of airflow obstruction, which is debilitating and has a high mortality rate. On the basis of a synergistic effect, compound drugs have been widely applied to treat said disease. In order to achieve the best therapeutic effect, two active ingredients should exhibit similar deposition behavior in the human lungs and should be delivered to an affected area to have a medicinal effect. Compared with the inhalation dosage forms of dry powder and atomization, the convenience and safety of patients when using a medicine is considered, and a method for preparing a micropowder of the active pharmaceutical ingredients of a compound inhalation aerosol is provided. The glycopyrronium bromide and indacaterol compound inhalation aerosol obtained by using the present preparation method can effectively increase the effective site deposition rate of glycopyrronium bromide, and can improve the degree of co-deposition between the two active ingredients. Processing is simple for the micropowder mixture of the active pharmaceutical ingredients of glycopyrronium bromide and indacaterol prepared by using the present preparation method as well as for a compound inhalation aerosol thereof, and the FPF of the active ingredients is significantly increased.
The exploration and dissection of a set of QTLs and candidate genes for gray leaf spot disease resistance using two fully assembled parental genomes may help expedite maize resistance breeding. The fungal disease of maize known as gray leaf spot (GLS), caused by Cercospora zeae-maydis and Cercospora zeina, is a significant concern in China, Southern Africa, and the USA. Resistance to GLS is governed by multiple genes with an additive effect and is influenced by both genotype and environment. The most effective way to reduce the cost of production is to develop resistant hybrids. In this study, we utilized the IBM Syn 10 Doubled Haploid (IBM Syn10 DH) population to identify quantitative trait loci (QTLs) associated with resistance to gray leaf spot (GLS) in multiple locations. Analysis of seven distinct environments revealed a total of 58 QTLs, 49 of which formed 12 discrete clusters distributed across chromosomes 1, 2, 3, 4, 8 and 10. By comparing these findings with published research, we identified colocalized QTLs or GWAS loci within eleven clustering intervals. By integrating transcriptome data with genomic structural variations between parental individuals, we identified a total of 110 genes that exhibit both robust disparities in gene expression and structural alterations. Further analysis revealed 19 potential candidate genes encoding conserved resistance gene domains, including putative leucine-rich repeat receptors, NLP transcription factors, fucosyltransferases, and putative xyloglucan galactosyltransferases. Our results provide a valuable resource and linked loci for GLS marker resistance selection breeding in maize.
Effective and safe use of Albuterol Sulfate HFA Inhalation Aerosol includes an understanding of the way that it should be administered.

Shake well before each spray.

Use Albuterol Sulfate HFA Inhalation Aerosol only with the actuator supplied with the product. Discard the Albuterol Sulfate HFA inhaler when the dose counter displays 0 or after the expiration date on the product, whichever comes first. Never immerse the canister in water to determine how full the canister is ("float test").

In general, the technique for administering Albuterol Sulfate HFA Inhalation Aerosol to children is similar to that for adults. Children should use Albuterol Sulfate HFA Inhalation Aerosol under adult supervision, as instructed by the patient's physician.
PURPOSE: A composition containing dandelion extract-derived oligosaccharide is provided to suppress inflammation-mediated factor transcription and to prevent and treat inflammation and diseases caused by oxidative stress. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammation and diseases caused by oxidative stress contains dandelion extract-derived oligosaccharide as an active ingredient. The oligosaccharide is obtained by extracting dandelion using water, low alcohol of 1-4 carbon atoms, or mixture solvent thereof and performing fraction and purification by chromatography. The composition contains 0.01-50 weight% of dandelion extract. The diseases caused by oxidative stress are hypertension, arteriosclerosis, stroke, steatosis, diabetes, cataract, AIDS, chronic bronchitis, alzheimer disease, parkinson's disease, stroke, or huntington disease. A health food for preventing and treating the diseases and inflammation contains the oligosaccharide as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, syrup, or beverage.
The invention relates to a new medicamentous form of sildenafil, in particular of sildenafil-citrate. It is a stable film-tablet, convenient for pharmaceutical manufacturing, of high strength and lowerasure. It is suitable for filming both with an organic and with an aqueous film coating. The film-tablet has a quick degree of dissolution of the medicamentous substance of sildenafil citrate. The lactose, included as an auxiliary substance, is not hygroscopic, has low humidity content and has no abrasive effect. The medicamentous form comprises lactose monohydrate, binder selected from povidon, hydroxypropylcellulose or hydroxypropylmethylcellulose, decaying auxiliary substance selected from crosscaramelosis sodium, sodium glycolate starch, crosspovidon, lubricant û sodium stearyl fumarateor magnesium stearate, preferably sodium stearyl fumarate, microcrystalline cellulose, siliconized microcrystalline cellulose and film-forming coating containing water soluble or water insoluble polymer.
In recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in the progression and development of several cancer types. These nano-sized vesicles are released by different cell lineages within the cancer niche and maintain a suitable platform for the interchange of various signaling molecules in a paracrine manner. Based on several studies, Exos can transfer oncogenic factors to other cells, and alter the activity of immune cells, and tumor microenvironment, leading to the expansion of tumor cells and metastasis to the remote sites. It has been indicated that the cell-to-cell crosstalk is so complicated and a wide array of factors are involved in this process. How and by which mechanisms Exos can regulate the behavior of tumor cells and non-cancer cells is at the center of debate. Here, we scrutinize the molecular mechanisms involved in the oncogenic behavior of Exos released by different cell lineages of tumor parenchyma. Besides, tumoricidal properties of Exos from various stem cell (SC) types are discussed in detail.
Participants (n=6) randomized to receive an in-person CI counseling session will receive what normally occurs with patients pursuing cochlear implantation. The counseling will last 30-45 minutes and consists 5 key components: an explanation of the patient's hearing testing results, a discussion of the impact of hearing loss on the patient's life, treatment options for hearing loss including hearing aid amplification and cochlear implantation, an explanation of how CIs function and the necessary steps in candidacy and rehabilitation, and an outline of the expected outcomes following cochlear implantation.
Pathological elevated intraocular pressure is one of the most important disease characteristics of glaucoma. Blockage of aqueous humor outflow within the eye is the primary cause of high intraocular pressure. The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor. Pathological changes in this area can lead to the development of high intraocular pressure and glaucoma, such as primary angle closure glaucoma (PACG) caused by angle closure. Minimally invasive glaucoma surgery has rapidly developed in recent years, with angle surgery being a major branch. With the use of surgical goniolens, structures within the angle, such as trabecular meshwork and Schlemm's canal, can be visualized clearly during surgery. Methods for angle intervention include but not limit ed to widening the peripheral anterior chamber angle, reopening adhered or appositionally closed angles, and rebuilt outflow pathways by incising diseased areas to increase aqueous humor outflow. Techniques include laser peripheral iridotomy (LPI) to relieve pupillary block and deepen the peripheral anterior chamber, Argon laser peripheral iridoplasty (ALPIP) to stimulate iris contraction and widen the angle, and mechanical separation of adhered angle tissues using instruments like goniosynechialysis hooks or iris repositors. Surgical incision using instruments such as Microhook, trabeculectomy hooks, or cannulas can be performed to remove the diseased inner wall of Schlemm's canal and the diseased trabecular meshwork either partially or circumferentially. However, the healing and outcomes of angle tissues following invasive angle interventions, and their impact on surgical outcomes, remain unclear. Therefore, our research team proposes to conduct imaging observation studies to track, observe, and quantify the status of the angle, exploring the healing process of angle tissues. This aims to provide theoretical support for the innovation and standardization of minimally invasive angle surgery.
A penicillin preparation is manufactured by contacting an anion-exchange material with a solution of a penicillin salt, causing adsorption of the penicillin anion, and then washing with a solution of an electrolyte such as sodium chloride to remove penicillin anion (and taste thereof) from the surface of the anion-exchange material. The anion-exchange material may be apatite, kaolinite, or, preferably, a polyamine resin such as the hydrolyzed reaction product of a t-amine (e.g. trimethyl amine) and a haloalkylated copolymer of styrene and divinyl benzene.  In examples the potassium salts of penicillin G and V are used. Examples V and VI illustrate the compounding of the products as pharmaceutical compositions. Specification 654,706 is referred to.ALSO:A pharmaceutical compositions comprises a penicillin preparation manufactured by contacting an anion-exchange material with a solution of a penicillin salt, causing adsorption of the penicillin anion, and then washing with a solution of an electrolyte such as sodium chloride to remove penicillin anion (and taste thereof) from the surface of the anion-exchange material.  Penicillin G and V are the drugs used and the anion-exchange materials specified are the apatites, kaolinites and the reaction products of t-amines with halogenated copolymers of styrene and divinyl benzene.  The resin-penicillin compounds may be put up into conventional solid and liquid forms which may be sucked, chewed or swallowed and which contain conventional excipients.  Fatty bases are specifically mentioned. Specification 654,706 is referred to.
The scope of this study is to engage Ryan White HIV/AIDS Program (RWHAP) funded organizations in the South/East US to co-develop context-responsive programs utilizing evidence-informed interventions to reduce structural racism and discrimination (SRD) against Black, Indigenous, People of Color (BIPOC) living with HIV (PLH) and BIPOC healthcare workers. SRD directly impacts access to and uptake of healthcare for BIPOC, including engagement in HIV services across the continuum of prevention and care. The proposed intervention, titled TRAnscenDS, draws on the evidence-based Health Policy Plus (HP+) 'total' facility HIV stigma-reduction intervention and Contact Theory of demonstrated efficacy in reducing race-related intergroup prejudice. TRAnscenDS targets the clinics' organizational (e.g.,anti-racist and diversity, equity and inclusion (DEI) policies) and systems (e.g., staff attitudes/behaviors) levels to affect patient (e.g., experienced and perceived discrimination, HIV care, mental health) outcomes and staff (e.g., job satisfaction) wellbeing, at the individual level. Findings will yield a Manual for implementing total-facility SRD-reduction processes and content. Other RWHAP-funded clinics and facilities serving marginalized groups may be able to adopt this manualized yet highly adaptable intervention packet to support BIPOC.
The present invention relates to a solid dispersion which comprises a proton pump inhibitor or a pharmaceutically acceptable salt thereof, an enteric polymer, and an alkalizing agent. The enteric polymer is contained in 100 to 200 parts by weight based on 100 parts by weight of the proton pump inhibitor or the pharmaceutically acceptable salt thereof. The alkalizing agent is contained in 100 to 150 parts by weight based on 100 parts by weight of the proton pump inhibitor or the pharmaceutically acceptable salt thereof. Also, the present invention relates to a manufacturing method of a solid dispersion and an orally disintegrating tablet including the same. The orally disintegrating tablet including the solid dispersion according to the present invention uses the enteric polymer in 100 to 200 parts by weight based on 100 parts by weight of the proton pump inhibitor. Therefore, oral cavity release can be possible by using a small amount compared to a conventional technique, and stability in acid is improved, so that an in vivo utilization rate can be also improved through oral administration.
Past experience has suggested that the ability to completely remove the thymoma using surgery is important in preventing recurrence. Strategies which would help the surgeon's ability to completely remove the tumor therefore need to be investigated.

This study represents a multi-institutional, phase II pilot trial of preoperative chemoradiotherapy followed by surgical resection and postoperative chemotherapy for patients with invasive thymoma or thymic carcinoma at significant risk for recurrence. We hypothesize that this strategy will be well-tolerated and produce response and resectability rates exceeding those previously published involving surgical resection alone, or preoperative chemotherapy followed by surgery. Patients with locally advanced thymoma, based on radiographic and biopsy criteria, will undergo pretreatment computed tomography (CT) scan and positron emission tomography (PET) followed by concurrent (simultaneous) chemotherapy (cisplatin and etoposide) and radiation. After this therapy, patients will be reassessed using computed tomography (CT) and PET, and undergo surgical resection of their tumors. Following resection, patients will be either observed, or treated with postoperative chemotherapy, or chemotherapy and radiation. Correlative genomic, serologic and pathologic studies will also be performed.
Sleep disturbance is frequently reported by women during the menopausal transition due to various physiological changes and environmental factors. Insomnia is a critical treatment target for its deleterious effects on daytime functioning and quality of life and increased risk of developing a depressive disorder. Due to medication side effects and patient preferences, there is increased interest in the use of psychological treatments that address the myriad of menopausal symptoms, including cognitive-behavioural therapy, clinical hypnosis and mindfulness-based therapies. The objective of this article is to review the effects of psychological treatments for menopausal symptoms on sleep disturbance in peri-/postmenopausal women. We conducted a systematic review of the literature using PubMed and reference lists from inception until May 2023, including 12 studies that evaluated sleep as a secondary outcome. Most studies found that group and self-help (guided and unguided) cognitive-behavioural therapies and clinical hypnosis for menopausal symptoms have positive effects on sleep among women with significant vasomotor symptoms. There was preliminary support for mindfulness-based stress reduction. Future research including more diverse samples and women with sleep disorders is needed. Evaluating the implementation of psychological therapies in clinics where menopausal women seek care is an important next step.
In a group cluster trial, a comprehensive, tailored, data-based social norms marketing campaign that addresses misperceptions of: 1) the acceptability of dating and sexual violence; 2) gender roles; 3) sexual activity; 4) sexual communication/consent; 5) support for victims; and 6) bystander intervention will be evaluated among middle schools. Poster messaging will be paired with several systematic efforts to diffuse program content through the community, including a Lunch and Learn Teacher Training, Social Norms Video, Teacher Workbook, Parent Mailing, and Parent Information Session. A member of the researcher-practitioner team, designated as a School Resource Provider, will oversee campaign implementation in partnership with a teacher champion. The Resource Provider will also track campaign intensity, assess campaign credibility through intercept interviews with teachers and students, work with teachers to infuse messaging into classroom activities, and assist the teacher champion with addressing "kick-back" to the campaign. Outcome assessments will be completed by teachers, administrators and students. Towards the goal of exploring the role of other environmental factors as moderators of program effects, school administrators will assess their community readiness to develop and implement school dating and sexual violence prevention policy, in general, and social norms marketing, in particular. A neighborhood scan will also be conducted to estimate the density of nearby outlets associated with gender-based personal violence.
Inflammation and coagulation are critical self-defense mechanisms for mitigating infection that can nonetheless induce tissue injury and organ dysfunction. In severe cases, like sepsis, a dysregulated thromboinflammatory response may result in multiorgan dysfunction. Sepsis-associated acute kidney injury (AKI) is a significant contributor to patient morbidity and mortality. The connection between AKI and thromboinflammation is largely due to unique aspects of the renal vasculature. Specifically, the interaction between blood cells with the endothelial, glomerular, and peritubular capillary systems during thromboinflammation reduces oxygen supply to tubular epithelial cells. Previous studies have focused on tubular epithelial cell damage due to hypoxia, oxidative stress, and nephrotoxins. Although these factors are pivotal in acute tubular injury or necrosis, recent studies have demonstrated that AKI in sepsis encompasses a mixture of tubular and glomerular damage subtypes. In cases of sepsis-induced coagulopathy, thromboinflammation within the glomerulus and peritubular capillaries is an important pathogenic mechanism for AKI. Unfortunately, and despite the use of renal replacement therapy, the development of AKI in sepsis continues to be associated with high morbidity, mortality, and clinical challenges requiring alternative approaches. This review introduces the important role of thromboinflammation in AKI pathogenesis and details innovative vascular-targeting therapeutic strategies.
The sleep-wake cycle is determined by circadian and sleep homeostatic processes. However, the molecular impact of these processes and their interaction in different brain cell populations are unknown. To fill this gap, we profiled the single-cell transcriptome of adult Drosophila brains across the sleep-wake cycle and four circadian times. We show cell type-specific transcriptomic changes, with glia displaying the largest variation. Glia are also among the few cell types whose gene expression correlates with both sleep homeostat and circadian clock. The sleep-wake cycle and sleep drive level affect the expression of clock gene regulators in glia, and disrupting clock genes specifically in glia impairs homeostatic sleep rebound after sleep deprivation. These findings provide a comprehensive view of the effects of sleep homeostatic and circadian processes on distinct cell types in an entire animal brain and reveal glia as an interaction site of these two processes to determine sleep-wake dynamics.