anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Current treatment options for primary renal cancer include surgery or ablative techniques-all are invasive or minimally invasive options. The completely noninvasive treatment option of stereotactic radiation therapy (SABR), which has become standard of care in many cancer sites, has not been explored for primary renal cancer. With multiple technological advances, it is now feasible to safely treat a moving intra-abdominal tumor such as that in a kidney. This proposed clinical trial evaluates the efficacy of SABR in treating patients with early renal cancers. Growing renal masses will first be biopsied to confirm the diagnosis of renal cancer. Patients will then undergo treatment with SABR of 3-5 fractions completing within three weeks. Treatment response will be evaluated using sequential MRI scans and a second tumor biopsy one year after treatment. Monitoring of treatment toxicity and kidney function will also be performed.
INTRODUCTION: Incisional hernias with a defect width of more than10 cm are considered complex. The European Hernia Society guidelines recommend that such hernias should only be repaired by surgeons with experience of component separation. The standard component separation technique now is posterior component separation with transversus abdominis release (PCSTAR). Questions are raised about the limits of this technique.
METHODS: A literature search of publications on PCSTAR was performed for any references to the limits of this technique in open incisional hernia repair. We found 26 publications relevant to answer this research questions.
RESULTS: The standard PCSTAR can generally be used for a defect width of up to 15-17 cm. For defects greater than 17 cm problems must be expected with procedural tasks involving closure of the posterior layer and anterior fascia. No data are available in the literature on the bridging rate for the posterior layer. However, our own experiences show that gaps (holes) occur in the very thin peritoneum/fascia transversalis during dissection and these must be carefully closed. Furthermore, bridging with an absorbable synthetic mesh is needed not so rarely. Closure of the anterior fascia is successful in 81.0-97.2% of cases. In addition to a further mesh for anterior fascial closure, the hernia sac bound with multiple, accordion-like stitches can also be used. For a defect width greater than 17 cm, the limits of PCSTAR become increasingly evident and can be overcome through special technical solutions for closure of the posterior layer and the anterior fascia.
A complex of inorganic plate powder-UV protecting material is provided to enhance photo stability of make up cosmetic product. A hydrophilic head area by chelating bivalent metal is produced on the surface of plate inorganic material. A hydrophilic area of lipid component on hydrophilic head area is arranged to face to the surface of inorganic material. A makeup component is contained in the remaining space after combining inorganic material, bivalent metal and lipid component. The plate inorganic material is talc, seicite or mica. The bivalent metal is Mg, Ca, or Ba. The lipid component is lecithin. A material for UV protection is diethylhexyl Syringylidene Malonate or caprylic/capric triglyceride.
The objective of the study is to pilot a parent-to-parent coaching model with experienced family members of children with IMV as parent coaches. Parent coaches will advise parents of children with IMV awaiting hospital discharge on strategies for advocating for home nursing. Parents and parent coaches will meet as needed and engagement will be tailored to parent preference: text messaging, video or phone conferencing, or in-person visiting in the family home or hospital. Points of contact, issues addressed, and time required will be collected as needs assessment data to appropriately size and scale a future intervention. Enrollment and exit assessments will include completion of the Family Empowerment Scale (FES) and a brief structured interview about parents' perceived impact and acceptability, which will provide pilot data to inform a future intervention. The investigator hypothesizes that parents will gain self-advocacy skills specific to recruiting home health nurses and improve the size of their home nursing workforce through this coaching model.
Eight weekly, 60-minute sessions at a university-based farm with booster sessions. Learning is structured around fun activities to provide information about the impact of cancer treatment on children's health, as well as the importance of nutrition and physical activity in survivorship. Each session is manualized and devoted to education, a behavioral strategy applied toward a weekly goal, a cooking demonstration/taste testing, and harvesting produce from the survivor garden. Modules are offered in a group format with families together.
Behçet's syndrome is a rare, chronic multisystemic inflammatory disorder also known as the Silk Route disease due to its geographical distribution. Behçet's syndrome is a multifactorial disease and infectious, genetic, epigenetic, and immunological factors contribute to its pathogenesis. Its heterogeneous spectrum of clinical features include mucocutaneous, articular, ocular, vascular, neurological, and gastrointestinal manifestations that can present with a relapsing and remitting course. Differential diagnosis is often hampered by the non-specific clinical presentation and the absence of laboratory biomarkers or pathognomonic histological features. The therapeutic approach is tailored on the basis of patient-specific manifestations and relies on glucocorticoids, colchicine, and traditional and biological immunosuppressants. Despite progress in the knowledge and management of the disease, unmet needs in diagnostics, monitoring, prediction, and treatment personalisation challenge clinical practice, making Behçet's syndrome a complex disorder associated with an increased risk of morbidity.
BACKGROUND: Malignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of morphological indicators of chromosomal instability (CI) like micronuclei (MN), chromatin bridging (CB), nuclear budding (NB), and multipolar mitosis (MM) on routine cytology smears is a promising tool to distinguish malignant from benign ascitic fluids. However, it has been scarcely evaluated in pleural effusions. The present study was conducted to evaluate the diagnostic value of these markers in differentiating between malignant and benign pleural fluids.
METHODS: It is a cross sectional study in which a total of 72 pleural fluid samples over a period of 2 years received in the cytology department of the hospital were evaluated. The cytological analysis was done by two independent cytopathologists and interpreted as either malignant or benign. Four morphological markers of CI were counted in the May-Grünwald Giemsa (MGG) stained smears of all the cases and the score was compared with the conventional cyto-morphological diagnosis.
RESULTS: Out of 72 cases, there were 42 malignant and 30 benign effusions on cytological examination. The mean score of micronuclei count, nuclear budding, chromatin bridging and multipolar mitosis in malignant effusions were 7.26 ± 2.74, 9.55 ± 5.53, 1.83 ± 1.17, and 2.21 ± 1.62 respectively that was significantly higher than the benign effusions (1 ± 0.71, 1.1 ± 0.86, 0.38 ± 0.50, and 0.15 ± 0.37 respectively) (p < .05). On Receiver operating characteristic (ROC) curve analysis, a cut-off of 5 for the MN count had a sensitivity of 88% and specificity of 100% in detecting malignant pleural effusion [Area under curve (AUC) 95.8%, p < .001].
CONCLUSION: Evaluation of morphological indicators of CI on routine MGG stained smears is a simple and cost-effective method to differentiate between benign and malignant pleural fluids.
The invention relates to crowfoot crack resistant cream for infants and a preparing method thereof. The cream comprises solid grease, liquid grease, a solid emulsifier, a plant anti-allergy component, a humectant, a plant extract and an antiseptic. The cream is suitable for skin dryness, peeling, crowfoot cracks in severe cases of infants which are caused by dry weather in autumn and winter. The cream is particularly nourishing and mild, and is extremely high in safety requirements and good in grease compatibility and compatibleness. Oat glucan having high moisturizing effects and the polyol type humectant are adopted so that moisturizing effects are good. The liquorice root extract and natural bisabolol are added further to solve a sensitive skin problem.
Group B was treated with conventional therapy. The interrupted galvanic electrical impulses with the duration of 3-30 milliseconds, the tolerable intensity was applied over the motor points of each facial muscle. A total of 30-60 electrical twitch induced muscle contractions will be maintained for each muscle. The facial muscles exercise training with mirror-visual feedback was progressed to resisted exercises by self and/or therapist-assistance. All exercises were demonstrated to participants by the therapist's efforts and instructed the participants to continue the exercises twice a day for 10-15 minutes. A pictorial leaflet of facial expressions exercises with appropriate instructions to perform exercises. Treatment frequency was five sessions/week for 4 weeks.
Immunoglobulin 4 (IgG4)-related disease is a chronic immune-mediated fibroinflammatory disorder. Involvement of the vascular system, including large- and medium-sized vessels, is increasingly recognized. The varied appearances of vascular involvement reflect the sequela of chronic inflammation and fibrosis and can include aortitis and periaortitis with resultant complications such as aneurysm formation and dissection. A diagnosis of IgG4-related large vessel involvement should be considered when there is known or suspected IgG4-related disease elsewhere. Other organs that are typically affected in IgG4-related disease include the lacrimal and salivary glands, thyroid, pancreas, biliary tree, lungs, kidneys, and meninges. Diagnosis typically requires careful correlation with clinical, imaging, serum, and pathologic findings. Patients may be managed with corticosteroid therapy or the anti-CD20 monoclonal antibody, rituximab, if needed. The varied clinical presentations and imaging features of large vessel involvement are discussed herein. Keywords: Vascular, Inflammation, Aorta, IgG4-related Vessel Involvement © RSNA, 2024.
Patients were administered 1 mg/kg by IV infusion once every other week (qow) for at least 12 weeks. After evaluation of 12-week safety, tolerability, and pharmacodynamic data in individual patients, the dose was increased to 3 mg/kg qow. Infusions were to be at least 10 days apart and were administered every 14 days ±5 days.
FIELD: medicine. SUBSTANCE: method involves treating a patient in two stages. The first stage involves applying radiological therapy, administering intravenous injections of 5-fluoruracyl, and platinum preparations to suppress tumor production activity of malignant cells and tumor sensitization. Irradiation is carried out in non-traditional mode of dynamical multifractioning: the first 3 big fractions are carried out with 1.8 Gr each twice a day in 4-6 h one after the other, then the procedure is carried out with 1.2 Gr twice a day in 4-6 h to reach the dose of 30-35 Gr. The tumor being located in the oral cavity, platidiam is administered before the big fractions at a dose of 90-100 mg. The second stage involves carrying out planned radical operation after having two weeks pause. EFFECT: enhanced effectiveness of treatment course.
Systems and methods are provided for three dimensional depth reconstruction of vessels in two dimensional medical images. A medical image comprising braches of one or more vessels is received. A branch overlap image channel that represents a pixelwise probability that the branches overlap is generated. A set of branch orientation image channels are generated. Each branch orientation image channel is associated with one of a plurality of orientations. Each branch orientation image channel representing a image channel represents a pixelwise probability that the branches are oriented in its associated orientation. A multi-channel depth image is generated based on the branch overlap image channel and the set of branch orientation image channels. Each channel of the multi-channel depth image comprises portions of the branches corresponding to a respective depth.
This study is designed as a prospective cohort study with only one cohort. Enrolment and data collection are performed by trained research staff who are not involved in the care of the patients. The primary measurement is the vestibular function tests including SOT, the caloric reflex test, vHIT, VEMP (cVEMP and oVEMP). The secondary measurements included PTA, DHI, and VAS. The sample size was set at 60 patients. The continuous variables were expressed as means ± standard deviation (SD) whereas categorical variables were expressed as frequency and percentage for data description. P \<0.05 was considered statistically significant.
In medicine and dentistry, image quality affects computer vision accuracy. However, some problems are more tolerant of noise depending on disease severity and radiographic obviousness. There is a need to have a noise estimation model that adapts to each specific domain. A noise estimation model is trained to output a set of domain noise estimates for an input image, each estimate indicating an impact of noise present in the input image on a particular domain, e.g. labeling of a dental feature such as a dental anatomy, pathology, or treatment. The noise estimation model is trained by processing image pairs with a set of machine learning models for a plurality of domains, the image pairs including a raw image and a modified image obtained by adding noise to the raw image. Outputs of the set of machine learning models for the raw and modified images are compared to obtain measured noise metrics. The noise estimation model processes the modified image and is trained to estimate noise metrics. The noise estimation model is modified according to differences between the measured noise metrics and estimated noise metrics.
The application provides a traditional Chinese medicine composition for treating cold hands and feet and a preparation method of a foot-soaking medicament, wherein the traditional Chinese medicine composition at least comprises the following raw material medicines in parts by weight: 20-40 parts of cassia twig, 20-40 parts of folium artemisiae argyi and 5-15 parts of fructus evodiae. 20-40 parts of cassia twig, 20-40 parts of folium artemisiae argyi and 5-15 parts of fructus evodiae are utilized according to the weight ratio. Cassia twig, ramulus Cinnamomi warms yang and unblocks collaterals, and folium Artemisiae Argyi and fructus evodiae are pungent and fragrant to dispel cold. The folium artemisiae argyi and the fructus evodiae are matched with each other, when the external application is carried out, the penetrating power of the folium artemisiae argyi and the penetrating power of the fructus evodiae are combined, the folium artemisiae argyi and the fructus evodiae can supplement each other and promote each other, so that a better penetrating effect is achieved, the effective ingredients can be absorbed more easily when the external application is carried out, the effects of warming meridians, dispelling cold and promoting peripheral blood circulation are achieved, and the problem that hands and feet are cold is solved. The peripheral blood circulation capacity of the user can be greatly improved, so that the rebound situation of stopping the medicine is improved as much as possible. And the traditional Chinese medicine composition is externally used instead of being orally taken, has small side effect and is suitable for wide crowds.
Two randomized, double-blind trials, 1 placebo-controlled and 1 active-controlled, were conducted in 964 immunocompetent adults with uncomplicated herpes zoster. Treatment was initiated within 72 hours of first lesion appearance and was continued for 7 days.  
  
In the placebo-controlled trial, 419 patients were treated with either famciclovir 500 mg three times daily (n=138), famciclovir 750 mg three times daily (n=135) or placebo (n=146). The median time to full crusting was 5 days among famciclovir 500 mg-treated patients as compared to 7 days in placebo-treated patients. The times to full crusting, loss of vesicles, loss of ulcers, and loss of crusts were shorter for famciclovir 500 mg-treated patients than for placebo-treated patients in the overall study population. The effects of famciclovir were greater when therapy was initiated within 48 hours of rash onset; it was also more profound in patients 50 years of age or older. Among the 65.2% of patients with at least 1 positive viral culture, famciclovir treated patients had a shorter median duration of viral shedding than placebo-treated patients (1 day and 2 days, respectively).  
  
There were no overall differences in the duration of pain before rash healing between famciclovir-and placebo-treated groups. In addition, there was no difference in the incidence of pain after rash healing (postherpetic neuralgia) between the treatment groups. In the 186 patients (44.4% of total study population) who developed postherpetic neuralgia, the median duration of postherpetic neuralgia was shorter in patients treated with famciclovir 500 mg than in those treated with placebo (63 days and 119 days, respectively). No additional efficacy was demonstrated with higher dose of famciclovir.  
  
In the active-controlled trial, 545 patients were treated with 1 of 3 doses of famciclovir three times daily or with acyclovir 800 mg five times daily. Times to full lesion crusting and times to loss of acute pain were comparable for all groups and there were no statistically significant differences in the time to loss of postherpetic neuralgia between famciclovir and acyclovir-treated groups.
PURPOSE: An antibody which specifically recoganizes acetylated BubR1 and a method and kit for detecting acetylation of BubR1 are provided to measure cell division check point activity. CONSTITUTION: An antibody specifically recognizes acetylated BubR1 protein. BubR1 is derived from Homo sapiens, Mus musculus, Gallus gallus, or Xenopus laevis. In homo sapiens-derived BubR1, 250th lysine residue is acetylated. In Mus musculus-derived BubR1, 237th lysine residue is acetylate. The antibody is Fv, ScFv, Fab, Fab' or F(ab')2. A kit for detecting acetylation of BubR1 in a sample contains the antibody for BubR1. The sample is derived from cancer tissue. A method for detecting acetylation of BubR1 comprises: a step of isolating the test sample; a step of contacting the sample to the antibody; and a step of determining acetylation of BubR1.
The invention provides a multivalent group B meningococcal protein vaccine. The multivalent group B meningococcal protein vaccine is a multivalent combined vaccine comprising outer menbrane vesicle (OMV) proteins of group B meningococcus strain CMCC29356, strain CMCC29361, strain xrsw341215 having preservation number of CGMCC No.8982 and strain xrsw210902 having preservation number of CGMCC No.8981, and optionally comprises a medicinal excipient and/or an adjuvant. The multivalent group B meningococcal protein vaccine has wide cross protection antibody titers for prevention of group B epidemic cerebrospinal meningitis around the world, and has good cross protection effects on group A and group C epidemic cerebrospinal meningitis. The invention provides a whole production technology of the multivalent group B meningococcal protein vaccine. The production technology is suitable for large scale production. A research result shows that the multivalent group B meningococcal protein vaccine has good immunogenicity, reliable safety and stable immunization endurance.
For prevention of EIB, a single 10 mg dose of SINGULAIR should be taken at least 2 hours before exercise. An additional dose of SINGULAIR should not be taken within 24 hours of a previous dose. Patients already taking SINGULAIR daily for another indication (including chronic asthma) should not take an additional dose to prevent EIB. All patients should have available for rescue a short-acting β-agonist. Safety and effectiveness in patients younger than 15 years of age have not been established. Daily administration of SINGULAIR for the chronic treatment of asthma has not been established to prevent acute episodes of EIB.
There is provided a method of saving medication costs by redistributing unused medications. The method first features the step of receiving a request to fill a prescription for the medication of a patient serviced by a patient care facility. Thereafter, unit doses of the medication are assembled based upon the prescription. Each of the unit doses are individually identified with a lot number and an expiration date. The method further features the step of distributing the assembled unit doses to the patient care facility. Then, an unused portion of the unit doses is received from the patient care facility. An amount of such unused portion is identified and credited to the patient care facility. The identified unused portion of the unit doses are stored and later redistributed so as to mitigate the cost of the medication.
All patients will receive the same L-serine dose treatment over 12 months. Arm: Experimental: L-Serine 250 mg / kg / day during the first two weeks. From week 3 to 52, 500 mg / kg / day. L-serine orally administered, divided into three doses a day.
OBJECTIVE: Emerging evidence suggests that the endometrial microbiome plays important roles in the development of endometrial cancer (EC). Here, we evaluate stage-specific roles of microbial dysbiosis and metabolic disorders in patients with EC, patients with endometrial hyperplasia (EH), and patients afflicted with benign uterine conditions (CK).
METHODS: This prospective cohort study included 33 women with EC, 15 women with endometrial EH, and 15 women with benign uterine conditions (CK) from November 2022 to September 2023. Different typical endometrial samples were imaged with a scanning electron microscope and a transmission electron microscope. The endometrial microbiome was assessed by sequencing the V3-V4 region of the 16S rRNA gene and the ITS1 to fill the gap in relation to the study of the uterine fungal microbiome. Moreover, liquid chromatography-mass spectrometry-based metabolomics was used to identify and quantify metabolic changes among these groups.
RESULTS: The endometrial microbiome revealed that there is a structural microbiome shift and an increase in the α-diversity in the EC and EH cases, distinguishable from the benign cases, especially the fungal community structure. The fungal microbiome from patients with EC and EH was altered relative to controls and dominated by Penicillium sp. By contrast, Sarocladium was more abundant in controls. Significant differences were observed in the composition and content of compounds between benign cases and EC, especially estradiol-like metabolism-related substances. Altered microbiota was correlated with the concentrations of interleukin-6 (IL-6), IL-11, transforming growth factor-beta, and β-glucuronidase activity especially the relative abundance increase of Penicillium sp.
CONCLUSIONS: This study suggested that the endometrial microbiome is complicit in modulating the development of EC such as estrogen activity and a pro-inflammatory response. Our work provides a new insight into the endometrial microbiome from a perspective of stages, which opens up new avenues for EC prognosis and therapy.