anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Laparoscopic appendectomy will be performed with the standard 3-port technique. The laparoscope is introduced via a 10mm subumbilical port. Dissection will be performed with a 5mm LLQ port and a 5mm RLQ port. Exploratory laparoscopy was first carried out to locate the appendix and to rule out other pathologies. The mesoappendix will be divided with the ultrasonic dissector (Sonosurg, Olympus surgical, Tokyo, Japan). The appendix will be ligated between two polydioxanone suture loops. The specimen will be delivered within a plastic bag via the subumbilical port. Purulent fluid will be irrigated and suctioned from the subhepatic space, right lower quadrant and the pelvis if present. Fascial defects will be closed with 2-O polydioxanone sutures and skin closed with 4-O absorbable subcuticular sutures. A pelvic drain (12Fr) will be inserted in cases of abscesses or gangrene.
The invention relates to the field of treating sepsis, in particular to a medicine which is capable of reducing the death rate of rats and relatively prolonging the survival time of the rats. Upon current studies, a fructus forsythiae extract is capable of destroying bacterial endotoxins and taking an inhibitory effect on various Gram-positive and Gram-negative bacteria; but since the action mechanism of the fructus forsythiae extract is not yet explained clearly completely, the popularization of the fructus forsythiae extract to international market is affected. According to the invention, substances are obtained through separation from a 50% ethanol extract of the fructus forsythiae by virtue of such methods as silica-gel column chromatography, Saphadex LH-20 column chromatography, recrystallization and the like; and the substances are subjected to structural identification by virtue of such methods as chemical identification, nuclear magnetic resonance hydrogen spectrum, nuclear magnetic resonance carbon spectrum, thin-layer chromatography, high performance liquid chromatography and the like, so that the structures and the names of the substances are determined. By copying a rat cecal ligation and puncture animal model, the pathological process of the sepsis in human bodies is simulated. Through tail intravenous injection administration, the postoperative survival rates of various rats after operations are observed. According to the invention, an injection, which is prepared by taking the forsythiaside A as a major component, is used for treating the sepsis.
At control sites, usual care will be provided, which may or may not include symptom screening, access to CPGs or care pathways. Participants will complete SSPedi to obtain the primary outcome at weeks 0, 4 and 8 but the scores will not be revealed to providers and will not be linked to care pathways.
The main objective is to study the post-surgical impact (post-S) of a Prehabilitation program on candidates for liver transplantation (LT), as well as to study the effects of posttransplant training on the clinical and functional evolution of the recipients. Also this project pretends to assess the influence of functional capacity (FC) improvement on the short and long term post-S evolution of the LT candidates. This is a prospective randomized clinical trial in which three phases follow: Prehabilitation, training and follow-up. The sample will be constituted by 60 candidates for LT, randomized in a control group (CG, n=20), a Prehabilitation group (PG, n=20) and a Prehabilitation-posttransplant training group (PTG, n=20). To conventional care, a Prehabilitation program will be added to the PG and PTG. After the LT, just PTG will follow a posttransplant training program. The long-term follow-up will be extended to 2 years post-LT. The variables under study will be: complications and post-S evolution; FC; quality of life; etc. The individualization of Prehabilitation and posttransplant training program, and also medical control, will ensure safety and offer the potential benefits that these types of programs can provide.
This invention provides various copolymers comprising a first repeating unit of the chemical formula:     ( see fig. I ) in which R1  and/or R2  are alkyl groups  and a  second repeating units generally having the chemical formula:     ( see fig. II ) ( see fig. III ) ( see fig. IV ) ( see fig. V ) ( see fig. VI ) ( see fig. VII ) and combinations of two or more thereof wherein R is a hydrogen atom or a methyl group and the first repeating unit is less than 45 weight percent of the total weight of the copolymer.   This invention also relates to use of these copolymers in the fabrication of absorbable surgical devices  such as  sutures  and as  coatings  for medical devices.     Additionally,   described  are  blends  and polyoxaesters containing the first repeating unit.
Vitamin C played pleiotropic roles in critical illness and vitamin C insufficiency was predictive of the development of multiple organ failure. Currently, the prevalence of vitamin C insufficiency in Chinese critically ill patients is rarely determined and there are no established bedside tools to predict hypovitaminosis C. To develop a nomogram to identify patients with high risk of hypovitaminosis C, we performed a bi-center prospective cohort study at two ICUs of the first and sixth medical center in PLA General Hospital, Beijing, China from May 6th to July 31st, 2021 We identified 322 eligible patients. 62.4% patients were hypovitaminosis C. 7 features, including source of infection, the level of serum albumin, age, male gender, sepsis, vascular disease, and wasting of vitamin C by the kidney, were selected using LASSO algorithm and therefore included in the nomogram. In the testing set, our model showed moderate discrimination ability with areas under the curve of 0.75 [0.64-0.84]. Variable importance evaluated by SHAP value highlighted two novel important predictors, i.e., abdominal infection and the level of serum albumin. In conclusion, we first reported a high burden of vitamin C insufficiency in Chinese adult patient in the ICU. We also constructed a prediction model to timely identify patients with high risk of hypovitaminosis C, which allows the clinicians to choose appropriate candidates for Vitamin C repletion in clinical practice or clinical trials.
BACKGROUND: Diabetic neuropathy (DN) is a serious microvascular complication and a major cause of morbidity and mortality in diabetes mellitus. It is characterized by neurodegeneration of terminal sensory nerve fibers with subsequent pain, loss of sensation, and paresthesia, thus compromising the quality of life of diabetic patients. It is considered the leading cause of non-traumatic amputations worldwide, reflecting the insufficiency of current therapies. Pramipexole (PPX) is a dopamine receptor agonist used for the treatment of Parkinson's disease. The current study aims to investigate the potential neuroprotective effect of PPX in an experimental model of DN.
METHODS: Sprague Dawley rats were randomly assigned into five groups: normal control, Normal + PPX (1 mg/kg) group, STZ control, STZ + PPX (0.25 and 1 mg/kg/day for eight weeks). The neuroprotective effect of PPX in rats was evaluated in terms of sciatic nerve histological alterations, oxidative stress, and protein expression of TLR4/MyD88/IRAK-1/TRAF-6/NF-κB axis and downstream inflammatory mediators.
RESULTS: PPX administration ameliorated histopathological signs of neuronal inflammation and apoptosis. Additionally, PPX attenuated STZ-induced sciatic nerve oxidative stress and downregulated neural tissue expression of TLR4, MyD88, IRAK-1, TRAF-6, NF-κB and downstream mediators (TNF-α, IL-1β and ICAM-1).
CONCLUSION: Collectively, the current study sheds light on PPX as a potential protective medication to alleviate neuropathy progression in diabetic patients. PPX neuroprotective effect can be attributed to modulating TLR4/ MyD88/IRAK-1/TRAF-6/ NF-κB axis signaling in nerve tissues with subsequent attenuation of oxidative stress and inflammation.
The utility model discloses an eye mask structure and relates to the structure of an eye care product. The utility model is designed to solve the problem that the prior mask structure fails to care the eyes well. The eye mask structure of the utility model is of a soft membrane type and consists of an eye coating which covers the eyehole region. The eye coating is arranged as a face-shaped type without porosity or secant. Moreover, the eye coating still contains a layer of care agents, which contains eye care ingredients. The utility model is specially used for sticking to the exterior of eyes, utilizes the layer of care agents to release helpful eye care ingredients and then achieves a unique efficacy of eye care.
PURPOSE: To obtain a dental curing composition useful as an excellent root canal filler and containing a hydrating self-curing calcium phosphate compound, an X-ray contrast medium carrying a high molecular material, a fluorine compound, an acid and water. CONSTITUTION: This dental curing composition comprises hydrating self-curing calcium phosphate compound (e.g.; α-tricalcium phosphate) as a main ingredient, an X-ray contrast medium a fluorine compound, an acid and water. The X-ray contrast medium carries a high molecular compound. The fluorine compound and the acid are blended so that the molar ratio of the fluorine atom in the fluorine compound against the calcium atom in the hydrating self-curing calcium phosphate compound and the molar ratio of the acid against the calcium atom are each 0.01-0.4. The dental curing composition is moderately adhesive as a pasty root canal filler, expresses an excellent operativeness, especially fluidity, has good filling property in the root canal and good curability, causes no stimulation to living bodies and is excellent in biocompatibility.
PURPOSE: To obtain a solid-like bathing agent having excellent storage stability and dispersibility into bathing water without generating floating or scum of an inorganic pigment nor climbing of inorganic pigment powder onto a bathing tank wall face, and capable of amusing color tone specific to an inorganic pigment. CONSTITUTION: This bathing agent contains following (a)-(c) components. (a) 5-80wt.% a carbonate (e.g.; sodium carbonate), (b) 0.5-10wt.% water-insoluble inorganic pigment powder (e.g.; titanium oxide) and (c) polyhydric alcohol in an amount of 0.01-1wt. times of the component (b) (e.g.; glycerin). Furthermore, an organic acid in an amount of 0.2-3wt. times of the carbonate is added and carbon dioxide is generated, and a foamable bathing agent is obtained, then especially preferably dispersibility is more improved. Other usual bathing agent component is suitably added and prepared to powder-like, granular-like or made to pellet-like, as necessary.
A pilot study will be conducted to evaluate the effectiveness of a technique designed to improve higher level attention (switching between tasks and multi-tasking) for persons with a traumatic brain injury. 32 individuals with TBI will be recruited. Baseline assessment includes neuropsychological evaluation using traditional measures as well as a completion of a number of questionnaires designed to measure everyday attention and everyday functioning. Participants are random assigned to either the experimental or control groups. Experimental and control treatments include two 60 minute sessions, twice per week, for 5 weeks. Follow-up assessment includes a neuropsychological evaluation using traditional measures as well as a completion of a number of questionnaires designed to measure everyday attention and everyday functioning. Protocol efficacy will be determined by improvements between baseline and follow-up on several objective and functional measures of divided attention and set-shifting.
<P>PROBLEM TO BE SOLVED: To obtain a glomerular epithelial cell repair agent capable of widely administered for nephrotic syndrome, scarcely causing problems of adverse effects.  <P>SOLUTION: The glomerular epithelial cell repair agent contains vitamin A or its derivative. When the glomerular epithelial cell is damaged, an enzyme for synthesizing retinoic acid which is a derivative of vitamin A and a retinoic acid receptor are remarkably expressed. The above fact means that the vitamin A or the derivative is effective for repairing a damage to the glomerular epithelial cell, and the fact is proved by experiments in which rats are used. The glomerular epithelial cell repair agent is widely administered for the nephrotic syndrome.  <P>COPYRIGHT: (C)2004,JPO
Patients will be given sulodexide 1200 LSU per day intravenously for 2 weeks. Then patients will receive 1000 LSU per day orally for 50 weeks.
Patients who routinely undergo bronchoscopy will be measured by EIT directly before, directly after and 10, 30, 60 minutes after bronchoscopy with a rubber belt which is placed around their chest. The EIT measurements will take 1-2 minutes; the total examination will last 1.5 hours.
SIP single injection 20ml of Ropivacaine 7,5mg/ml is injected under pectoralis major muscle on both sides of sternum. Injection is done under ultrasound guidance.
Background and Objectives: Inflammatory proteins and their prognostic value in patients with carotid artery stenosis (CAS) have not been adequately studied. Herein, we identified CAS-specific biomarkers from a large pool of inflammatory proteins and assessed the ability of these biomarkers to predict adverse events in individuals with CAS. Materials and Methods: Samples of blood were prospectively obtained from 336 individuals (290 with CAS and 46 without CAS). Plasma concentrations of 29 inflammatory proteins were determined at recruitment, and the patients were followed for 24 months. The outcome of interest was a major adverse cardiovascular event (MACE; composite of stroke, myocardial infarction, or death). The differences in plasma protein concentrations between patients with vs. without a 2-year MACE were determined using the independent t-test or Mann-Whitney U test to identify CAS-specific prognostic biomarkers. Kaplan-Meier and Cox proportional hazards analyses with adjustment for baseline demographic and clinical characteristics were performed to assess the prognostic value of differentially expressed inflammatory proteins in predicting a 2-year MACE in patients with CAS. Results: The mean age of the cohort was 68.8 (SD 10.2) years and 39% were female. The plasma concentrations of two inflammatory proteins were significantly higher in individuals with a 2-year MACE relative to those without a 2-year MACE: IL-6 (5.07 (SD 4.66) vs. 3.36 (SD 4.04) pg/mL, p = 0.03) and CD163 (233.825 (SD 230.306) vs. 159.673 (SD 175.669) pg/mL, p = 0.033). Over a follow-up period of 2 years, individuals with elevated levels of IL-6 were more likely to develop MACE (HR 1.269 (95% CI 1.122-1.639), p = 0.042). Similarly, over a 2-year period, patients with high levels of CD163 were more likely to develop MACE (HR 1.413 (95% CI 1.022-1.954), p = 0.036). Conclusions: The plasma levels of inflammatory proteins IL-6 and CD163 are independently associated with adverse outcomes in individuals with CAS. These CAS-specific prognostic biomarkers may assist in the risk stratification of patients at an elevated risk of a MACE and subsequently guide further vascular evaluation, specialist referrals, and aggressive medical/surgical management, thereby improving outcomes for patients with CAS.
KEY POINTS: Vacuolar casts are a distinct type of casts identifiable by urinary sediment microscopy. Identification of urinary vacuolar casts is associated with the presence of an advanced and severe form of a proteinuric glomerular disease.
BACKGROUND: Identification of casts by urinary sediment microscopy is a valuable diagnostic clinical tool for the evaluation of kidney disease. Vacuolar casts are an unrecognized unique type of casts characterized by the presence of nonpolarizable, clear vesicles of various sizes contained within a cast matrix, different from lipid casts, erythrocyte casts, or any other casts. We aimed to gain better understanding of the clinical relevance of these casts by establishing a multinational collaborative group to search for cases in which vacuolar casts were identified.
METHODS: Leveraging an educational social media platform, we conducted a multinational observational study extracting cases of patients who presented with urinary vacuolar casts during evaluation for impaired kidney function. Parameters assessed included degree of proteinuria and kidney dysfunction, clinical and histopathological diagnosis, and severity of renal parenchymal scarring on biopsy. A control group of patients without vacuolar casts was included for comparison.
RESULTS: Forty-six patients with urinary vacuolar casts were compiled from six countries. Nephrotic range proteinuria (82%), glomerular etiology (98%), and advanced CKD stage (62% 3B-5) were salient features. Histopathological diagnosis was available in 26 (57%) patients. Combining clinical and pathological diagnoses, diabetic nephropathy (48%), arterionephrosclerosis (30%), podocytopathies (15%), and proliferative glomerulonephritides (15%) accounted for most patients. Vacuolization of tubules or podocytes was present in 61% of the specimens. When compared with patients with histopathological diagnoses in which vacuolar casts were not found (n=186), patients with vacuolar casts more frequently had a glomerular etiology (100% versus 71%, P = 0.002), had greater proteinuria (median urine protein-to-creatinine 10.3 versus 2.2 g/g, P < 0.001), and had greater proportion of patients with ≥30% glomerular obsolescence (46% versus 20%, P = 0.003).
CONCLUSIONS: Thus, urinary vacuolar casts are strongly associated with advanced glomerulopathies with severe proteinuria. Future studies should examine their origin, composition, and prognostic value.
PODCAST: This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/K360/2024_01_26_KID0000000000000346.mp3
PURPOSE:To provide the titled composition for promoting the absorption of a drug, by using lecithin as an essential component. CONSTITUTION:A pharmaceutical composition containing a quinazoline compound (e.g. the compound of formula I, the compound of formula II, etc.) and useful as a remedy for hypertension is produced by using lecithin (preferably the one extracted from albumen or soybean, etc., and having a phase transition temperature of <=37 deg.C) as an essential component. It is administered in the form to effect the transcutaneous or rectal absorption, i.e. as an ointment or suppository.
The emergency department (ED) of National Taiwan University hospital manages a large amount of patients load in Taipei metropolitan. The short-stay unit in our ED is a pool for those needing observation or following management. However, the length of ED stay seems to be longer than those reported in western literature. It might be caused by limited facility availability of our ward. Actually, the bed vacancy of our ward is not only reserved for patients from ED but also for those from outpatients or other hospitals. A full ward for taking over the patients from ED only might be a solution in the future. However, internists and surgeons who care most of hospitalized patients are currently believed not a career priority because of their high risk and loading but relative low payment by National Health insurance in Taiwan. Under the deficiency of residents for patient-care, a system of hospitalist-run ward should be established.

The role of hospitalist, an in-patient physician, has been discussed since 1996. The pros and cons were debated controversially. The disadvantage is that the continuity of patient care will be interrupted by primary care physician. In addition, discharged summary are usually not completed in following clinic. On the other hand, the hospitalists need less cost than internists in recent studies but the quality and safety was considered similar. Actually, it is widely accepted that hospitalist can do an efficient job of handling inpatient admissions. The field has also continued to grow worldwide in recent decades. A hospitalist-run ward becomes more frequent for common but relatively low risk diseases including exacerbation of chronic obstructive pulmonary disease, pneumonia, urinary tract infection, ischemic stoke, cellulitis and congestive heart failure. Of course, some disease entities need longer length of hospital stay in nature.

We are thus interested in the efficiency of a hospitalist-run ward in Taiwan. Therefore, we set up a hospitalist-run ward for taking over the patients who needed hospitalization from our ED and observe the performance of the ward and the outcome of the in-patients.
This invention relates to compositions comprising an adenosine derivative and a deaminase inhibitor for the prevention and treatment of fungal and fungal-like infections. Infections which are treatable and preventable with these compositions are responsible for fungal diseases such as candidiasis, cryptococcosis, blastomycosis, aspergillosis, paracoccidiodomycosis and coccidioidomycosis, and the fungal-like diseases nocardiosis and actinomycosis. The invention also relates to methods for utilizing these compositions in treatment regiments. Treatments may be either in vivo or in vitro. In vivo treatments involve administration of compositions of the invention to mammals suspected or at risk of being infected with a fungal or fungal-like organism. In vitro treatments involve incubation of cells, tissues, food products, biological products derived from living materials or foods with compositions of the invention.
A device may receive, from multiple systems, data related to an individual. The device may anonymize, after receiving the data and using an anonymization technique, information included in the data that identifies the individual. The device may apply a formatting to the data after anonymizing the information that identifies the individual. The device may identify, after applying the formatting to the data, historical data related to the individual, to a provider associated with a claim for care, or to historical claims, and population data associated with demographics of the individual. The device may process, in association with identifying the historical data and the population data, the data using a machine learning model. The machine learning model may be associated with generating a prediction related to the individual or the care provided to the individual. The device may perform one or more actions based on the prediction.
This is a prospective, non-randomized, single-arm, multi-center study. A projected 100 patients will receive the stent(s) in this study at approximately 10-15 European sites. The primary objective is to evaluate the safety and performance of the Dynalink®-E everolimus eluting peripheral stent system for the treatment of patients with atherosclerotic de novo or restenotic native superficial femoral or proximal popliteal lesions.
TTAX03 is a sterile, lyophilized and micronized particulate human AM and UC product manufactured using aseptic processing followed by terminal sterilization by gamma irradiation in compliance with current Good Tissue Practices (cGTP) and current Good Manufacturing Practices (cGMP) to preserve extracellular matrices and growth factors/cytokines therein without any living cells. 10 mg of TTAX03 in a 0.5 mL solution of sterile, preservative-free 0.9% NaCl (saline).