anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
It is accepted to explain increasing of venereal diseases during years of the Revolution by degradation of morality and general disorder of system of state administration and sanitary services in Russia. The cross-verification of information presented in scientific publications and primary information sources makes it possible to look into following issues: degree of venereal (syphilitic) contamination of population of pre-revolutionary Russia; influence on sanitary statistics by erroneous diagnostics and convictions of Zemstvo medicine about predominantly non-sexual path of transmission of syphilis pathogen in Russian countryside; dynamics and sources of venereal morbidity in wartime. The high indicators of pre-revolutionary statistics of venereal infections could be affected by diagnostic errors. The "village syphilis" encountered in public milieu could be completely different disease not sexually transmitted and not chronic form of disease. The primary documents allow to discuss increasing of the number of venereal patients during war years, that however, does not reach catastrophic numbers that can be found even in scientific publications. This is also confirmed by data of Chief Military Sanitary Board of the Red Army for 1920s and statistical materials of People's Commissariat of Health Care of the RSFSR. The high morbidity was demonstrated by same Gubernias that were problematic before the Revolution and only later by those ones through which during the war years passed army masses. In Russia, total level of syphilis morbidity after the end of Civil War occurred to be more than twice lower than in pre-war 1913 and continued to decrease under impact of sanitary measures of Soviet public health.
''Migrant Elderly Women with Chronic Diseases'' who constitute the sample of the study will be informed about the Health Seeking Behavior Training based on Motivational Interviewing Techniques by obtaining the necessary permissions. After the intervention group and control group are determined by simple randomization method, pre-tests will be applied to both groups through face-to-face interviews. For the individuals in the intervention group, the days on which the Health Seeking Behavior Training Based on Motivational Interviewing Techniques will be implemented will be determined. The "Migrant Elderly Women with Chronic Diseases" in the intervention group who will receive Health Seeking Behavior Training based on Motivational Interviewing Techniques will be divided into four groups (the researcher who will conduct the application will interview the individuals in the 4 groups individually for 4 days). The interviews will be conducted 4 days a week (Monday, Tuesday, Thursday and Friday), lasting 4 weeks and each session will last approximately 30-35 minutes. Individuals who will come to the face-to-face training and belong to the intervention group divided into four will be called by the researcher for the training and called to a room with a therapeutic environment at the university. In addition, interviews will be continued by providing a therapeutic environment. The researcher will conduct interviews with each group on the days and times they have jointly planned. Thus, face-to-face practice will be carried out with a group every day. After the completion of the Health Seeking Behavior Training based on Motivational Interviewing Techniques, post-tests will be applied to the intervention and control groups through face-to-face interviews.

In the control group, pre-tests will be collected and no intervention will be made. For the post-test, the patients will be interviewed face-to-face on the agreed appointment date and post-test data will be collected in line with the data collection tools.
PURPOSE: Provided are novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. CONSTITUTION: A radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents are also useful for the treatment of diseases associated with infection and inflammation. The radiopharmaceuticals are small molecules and so do not suffer from the disadvantages associated with radiolabeled proteins or antibodies. As antagonists, the radiopharmaceuticals have significantly diminished risk of producing side-effects. The radiopharmaceuticals have utility in the rapid detection of inflammatory or infectious diseases such as inflammatory bowel, fever of unknown origin, reperfusion injury and transplant rejection. The reagents are useful in the treatment of diseases associated with infection and inflammation.
They will be asked to lie on the acupressure mat for 15 minutes once a day, 3 days a week (Monday, Wednesday, Friday). A reminder message will be sent on the morning of the application so that participants do not forget and are motivated. After each application, participants will be asked to fill out the session monitoring chart.
OBJECTIVE: To investigate the incidence of perioperative deep venous thrombosis (DVT) of lower extremities and its risk factors in elderly patients with femoral neck fracture.
METHODS: The clinical data of 4 109 elderly patients with femoral neck fracture admitted between August 2012 and November 2020 and met the selection criteria were retrospectively analyzed. Among them, there were 1 137 males and 2 972 females; their ages ranged from 65 to 101 years, with an average of 77.0 years. The time from fracture to admission ranged from 1 to 360 hours, with an average of 35.2 hours. There were 1 858 cases of hemiarthroplasty, 1 617 cases of total hip arthroplasty, and 634 cases of internal fixation surgery. The preoperative age-adjusted Charlson comorbidity index (aCCI) was 4 (3, 5). Perioperative DVT occurred in 857 cases (20.9%). Univariate analysis was performed on age, gender, body mass index, fracture side, time from fracture to admission, operation type, anesthesia type, blood transfusion, blood pressure after admission, and preoperative aCCI in patients with and without perioperative DVT, and logistic regression analysis was used to screen the risk factors of perioperative DVT in elderly patients with femoral neck fracture.
RESULTS: Univariate analysis showed that there were significant differences in age, gender, time from fracture to admission, operation type, and preoperative aCCI between the two groups ( P<0.05). Further logistic regression analysis showed that age>75 years, female patients, time from fracture to admission>24 hours, and preoperative aCCI>5 were risk factors for perioperative DVT ( P<0.05).
CONCLUSION: Elderly patients with femoral neck fracture have a higher incidence of perioperative DVT. The advanced aged and female patients, patients with longer fracture time and more comorbidities need to pay special attention to the prevention of perioperative DVT to minimize the occurrence of DVT during femoral neck fractures.
PROBLEM TO BE SOLVED: To provide a new stereoisomeric indole compound having physiological activities such as lipid peroxidation suppressing activity and utilizable as pharmaceuticals and cosmetic materials, etc. SOLUTION: This stereoisomeric indole compound is expressed by formula I [X is a 1-5C alkyl which may be substituted with OH, COOH, benzyl, etc.; R is H, an alkyl, an aralkyl, a cycloalkyl, an aryl, a univalent metal, etc.; R1 and R2 are each H, an alkyl, an aralkyl, a cycloalkyl or aryl; * represents asymmetric carbon atom] or its salt, e.g. (1"S,3"S)-indole of formula II. The compound of the formula I can be produced by condensing L-tryptophan of formula III with a stereoisomeric α-amino acid of formula IV to obtain a compound of formula V and subjecting the compound to oxidative cyclization reaction to construct an oxazole ring at a stroke.
The present invention relates to utrons, RNA molecules which contain promoter regulatory motif(s) and DNA analogs thereof and DNA molecules that can be transcribed to produce the foregoing. In particular, the invention provides gene promoter suppressing nucleic acids which suppress transcription from a promoter of interest. In a preferred embodiment, the invention provides the TSU gene, nucleotide sequences of the TSU gene and RNA, as well as fragments, homologs and derivatives thereof. Methods of isolating TSU genes are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are also provided. In particular, the invention relates to methods for cell replacement therapy, gene therapy or organ transplantation wherein TSU nucleic acids suppress MHC class I and II gene expression, thus preventing immuno-rejection of non-autologous cells or organs. The invention also provides methods for treatment of diseases or disorders by suppression of MHC class I, MHC class II, ICAM-1, B7-1, B7-2, and/or Fc gamma R expression by provision of TSU function.
Mesothelioma is a cancer that develops from serosal surfaces usually in response to prior asbestos exposure. A history of asbestos exposure can be elicited in more than 80% of mesothelioma victims. However, asbestos exposure alone is not sufficient to cause the development of mesothelioma. Nearly 27 million individuals in the US, were exposed to asbestos in the work place between 1940 and 1979 but just 3,000 new cases of mesothelioma are diagnosed each year. Therefore, the investigators hypothesis is that genetic variation in addition to asbestos exposure, and host factors contribute to the development of mesothelioma. It is estimated, based on the investigators preliminary studies, that a population in excess of 1,000 subjects with mesothelioma is required to perform a valid GWAS.

Therefore a multicenter approach is necessary to collect data and DNA on sufficient numbers with mesothelioma to adequately evaluate genetic risk. It is the aim of this proposal to develop a consortium of mesothelioma investigators to share phenotypic data and DNA samples and to perform genome wide association scanning (GWAS).
Subjects receiving cisplatin-based chemotherapy without receiving SENS-401. This control arm will provide natural history data, particularly the incidence and the time to onset of hearing impairment due to ototoxicity.
PROBLEM TO BE SOLVED: To promote the production, e.g. increase of body weight in a living animal, production of milk and eggs, etc., in monogastric and ruminant animals by using balhimycin. SOLUTION: This balhimycin of the formula, if necessary, in combination with a balhimycin derivative is administered to an animal. Among the balhimycin derivative, dimethylbalhimycin, dimethylleucylbalhimycin, etc., are preferable. Balhimycin is preferably obtained by fermentation of a microorganism, Actinomycete sp. DSM 5908. Balhimycin is preferably administered in a dosage of 0.1-600mg per kg body weight a day. In many cases, it is better to add this active component in a form of premix to a feed as the administrating form. The premix is obtained by mixing the active components with e.g. a wheat bran or the like. It is preferable to contain 0.5-15wt.% of the active component in the premix. Also a concentration of the active component in a feed is preferably 0.1-100mg/kg.
The present invention discloses an aceraceous plant extract and its extracting process and application. The aceraceous plant extract is extracted from Aceraceae AcerLinn plant by using water-alcohol or water-acetone as solvents and using a microwave method. The invention uses a microwave assistant extraction method to obtain the extract having higher fatty acid synthase inhibiting activity from the Aceraceae AcerLinn plant. The extract can be widely applied to preparation of drugs for reducing fat and preventing cancers, which has very high medicinal value. At the same time, the invention shortens the extraction time of effective substance in the leaves of the Aceraceae AcerLinn plant to 10-16s by selecting factors of appropriate extraction solvents, microwave power, microwave treatment time, duty ratio and so on. The extraction method is simple and the efficiency is high. The extraction method sufficiently embodies the huge advantage of the microwave process and has great application value.
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide. In addition, the relative risk for clinically significant coronary artery disease in patients with major depression is also 2 or more in studies that independently controlled for risk factors such as smoking, hypertension, etc. The principal long-term goals of the CNE include the determination of the mechanisms that underlie enhanced susceptibility to premature ischemic heart disease in patients with major depression, documenting the age at which demonstrable pathophysiologic or predictive changes begin to occur, and charting their rate of progression. Our long-term goal is to use our understanding of underlying mechanisms to enhance our capacity to predict who with major depression is most likely to develop premature ischemic heart disease, to determine what the mechanisms underlying this susceptibility are, and to develop improved means for treatment and prevention.

Depressed patients are known to manifest a variety of neuroendocrine changes that predispose to coronary artery disease including hypercortisolism, decreased secretion of growth hormone and a deficiency of sex steroids. A final common denominator of these neuroendocrine abnormalities is insulin resistance. Insulin resistance promotes several changes that would favor hypertension and increased coronary artery disease including increased sodium retention, increased activity of the sympathetic nervous system, proliferation of vascular smooth muscle and deposition of highly metabolically active visceral fat. The latter induces additional risk factors for coronary disease, including dyslipidemia, hypercoagulation, and enhanced inflammation. It is a matter of public health importance to document the frequency and severity of insulin resistance in patients with major depression compared to a closely matched group of healthy controls. To accurately quantify insulin resistance in each patient and control, we will apply the hyperinsulinemic euglycemic glucose clamp procedure. This is the gold standard method for measuring the insulin sensitivity since it reflects the direct human body glucose metabolic response to a known insulin infusion. Moreover, it is essential to use this technique in patients with major depression as data indicate that other alternative procedures give unreliable results in the context of hypercortisolism.
Fluid is the mainstay treatment in sepsis resuscitation, but the effects of different crystalloid and colloid solutions on outcome remain unknown.

Previously, a high molecular weight hydroxyethyl starch, HES 200, was used, but this was found to cause acute kidney failure in patients with severe sepsis. As kidney failure is an independent risk factor for death in these patients, HES 200 is not used anymore. In stead a lower molecular weight starch, HES 130, has been developed. Presently, this is the preferred colloid in Scandinavian intensive care units (ICU), but the effects of HES 130 in ICU patients are currently unknown. The proposed Scandinavian multicentre study will be conducted to assess if HES 130 contributes to acute kidney failure in patients with severe sepsis. As HES 130 is widely used, the trial will provide important safety data to clinicians who resuscitate septic patients.
This study will evaluate evidence-based treatments for adults with mild Primary Progressive Aphasia (PPA). The aim of the study is to help identify efficacious communication and quality of life interventions for those with PPA and their care-partners.

Participants with a diagnosis of PPA and their actively-engaged care partners will be involved in the study for 12 months. Each participant will receive a iPad equipped with the necessary applications and features for the study. Participants will complete evaluations, speech therapy sessions with a speech and language therapist, and sessions with a licensed social worker or related clinician. They will have access to Communication Bridge, a personalized web application to practice home exercises that reinforce treatment strategies. There are no costs to participate in this study.
PROBLEM TO BE SOLVED: To obtain the subject pack capable of effectively making skin pores astringent by including a gelation mucilaginous agent and a skin pore astringent ingredient and making the appearance transparent or translucent. SOLUTION: This pack is obtained by including (A) a gelation mucilaginous agent, e.g. a synthetic polymer having a network structure capable of including water (e.g. a carboxyvinyl polymer or polyacrylic acid) and (B) a skin pore astringent ingredient (e.g. Arnica montana L., Aloe or Hamamelis virginiana L.) and preferably further (C) a refreshing agent (e.g. menthol). In the above pack, the amounts of the formulated ingredients based on the total amount of the cosmetic part except a support and expressed in terms of solid are preferably 0.001-15 wt.% of the ingredient B and 0.005-0.4 wt.% of the ingredient C.  Since the appearance has transparency in the above pack, the pack can readily be located to confirm the state of skin from the upper side of a sheet and is good in follow-up properties, etc., to the skin without a sense of incompatibility when applying the pack to the skin of a nose, etc.
Phenolic polymers are prepared by oxidizing and polymerizing starting organic compounds comprising at least one hydroxyl group and at least one carbonyl group or at least two hydroxyl groups on an aromatic structure. One or more inorganic compounds or salts is added and the solution is allowed to stand at about 20° C. to 80° C. for a period of about at least 2 hours. Salt molecules as well as starting compounds and other low molecular-weight materials below about 500 to about 10,000 daltons are removed from the product solution. Purified phenolic polymers are prepared in concentrated aqueous solution or in dried powder form in a final step, if necessary. The resultant phenolic polymers exhibit physicochemical properties strongly resembling those of typical commercially-available natural-product soil extracts. The materials are active influenza anti-viral agents, and are effective in anti-viral compositions for treating or preventing influenza viral diseases.
Patients diagnosed with COVID-19 will be in this group. No additional intervention will be applied in this group except the routine COVID-19 treatment according to the Adult Patient Treatment Guide which published by the Ministry of Health, Republic of Turkey on 9 October 2020.
Type of Study: The study was designed as a randomized controlled experimental study. Place and Time of Research:

The research was conducted between March 2022 and December 2023 as a randomized controlled experimental study. The study population consisted of patients who sought treatment at the Orthopedics Polyclinic and Emergency Department of Erzurum Atatürk University Health Research and Application Center. These patients were referred to the orthopedics clinic and diagnosed with fractures, such as humerus, wrist, finger, tibia, femur, and ankle fractures, for which plastering was performed as treatment. Specifically, the study included children aged 6 to 12 years. The sample size for the study was determined through a power analysis and ultimately consisted of a total of 70 children, with 35 children assigned to both the control group and the kaleidoscope group. The children in the kaleidoscope group were exposed to a kaleidoscope, while the control group received no intervention beyond routine medical practice. To collect data, the researchers utilized an "Introductory Information Form," the "Wong-Baker Faces Pain Rating Scale," and the "Children Fear Scale." The data were analyzed using percentage distributions, mean, standard deviation, chi-square test, and independent groups t-test. Throughout the research, ethical principles were strictly followed.
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the second leading cause of cancer-related deaths globally. Transarterial chemoembolization (TACE) is recommended as standard therapy for intermediate-stage HCC according to the current guidelines and is also the most widely used in advanced HCC in real-world practice. Portal hypertension increases the risk of hepatic decompensation, which impairs survival in patients with HCC. Clinically significant portal hypertension is defined as \>10 mmHg increase in the hepatic vein pressure gradient (HVPG), and the current gold standard for its assessment is direct measurement, through a transjugular approach. However, due to its invasive character and high effort, HVPG measurement is not a standard tool in the initial diagnostic evaluation of patients with HCC. This study aims to evaluate the impact of non-invasive CT-based Hepatic Venous Pressure Gradient (HVPG) assessment on prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE).
The data collection consists of three sessions, before and after the 24-week intervention program, and 6 months post-intervention. Prior to the data collection, participants will be assessed for eligibility criteria and explained the detailed study procedures by trained research staff for informed consent. After completing the written informed consent, participants will be interviewed using detailed questionnaires relating to their health, nutrition, and dietary status, psychosocial measures, and undergo a series of physical examinations. These examinations include physical performance tests of mobility and gait, balance and strength, body measurements of weight, height, body mass index (BMI), waist-hip circumference, mid-upper-arm and calf circumference, blood pressure, and blood tests that will examine participants' clinical profile, biomarkers, and immunoassays. Participants will also be given Fitbit trackers to determine if they have improved their physical activity. Last, data collected will also include Functional near-infrared spectroscopy (fNIRS), a non-invasive procedure to determine the oxygenation levels of participants at rest and while doing some thinking activities. This data collection procedure will be conducted at baseline before the intervention and after the completion of the intervention.

The intervention will include a weekly, 24-week urban farming program. Each weekly session is where participants will engage in outdoor and indoor horticultural activities ranging from fertilization, sowing, and watering, to transplanting, maintaining, and harvesting vegetables and herbs.
The present invention provides an oil-control composite material, obtained by performing high-pressure homogenization on a mixture. The mixture comprises: 0.0001-6 parts by mass of fullerene; 1-50 parts by mass of hydroxyapatite; 0.1-30 parts by mass of zinc oxide; and 30-90 parts by mass of a base material, the base material being selected from at least one of synthetic fluorphlogopite, silica, aluminum oxide, and silicone powder. The present invention also provides a preparation method for the oil-control composite material. The present invention further provides a cosmetic. The oil-control composite material provided by the present invention has the functions of selectively adsorbing sebum, flocculating sebum, and preventing sebum oxidation, and a closed loop from selective adsorption of sebum to flocculation of sebum and to prevention of sebum oxidation can be formed, thereby completely solving the influence of sebum on makeup. In addition, the oil-control composite material provided by the present application further has low cytotoxicity and has the effect of reducing ultraviolet transmittance and the like.