anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The inflammatory potential of the diet, as measured by the Dietary Inflammatory Index (DII®), has been repeatedly shown to be associated with various inflammatory markers and mental and physical health outcomes. Of specific importance, several cross-sectional studies revealed mixed results regarding the correlations between the DII and sleep outcomes. Hence, in the current paper, a systematic review that examines the associations between the DII, sleep duration, and sleep quality was performed. The PubMed database was systematically searched for studies published up to November 2023 following PRISMA guidelines. Only cross-sectional studies that assessed the DII, sleep duration, and sleep quality across healthy and unhealthy cohorts were included. Eleven and seven studies were included in the systematic review for sleep quality and duration, respectively. The results of the present systematic review show that pro-inflammatory diets may be associated with poor sleep outcomes (duration and quality); however, as the current literature is inconsistent and limited, further cross-sectional studies in larger cohorts are necessary to (i) explore this relationship to address this heterogeneity and (ii) explore populations that are more sensitive to diet-induced inflammation.
The invention relates to an intelligent pharmacy information management system and method. The intelligent pharmacy information management system at least comprises a central server, wearable equipment and an intelligent pharmacy module. The intelligent pharmacy module is configured to acquire medical information of a user and distribute medicines corresponding to the medical information to the user based on the medical information; the central server has a three-dimensional database corresponding to a hospital two-dimensional map layout corresponding to the medical information. The wearable device is capable of establishing a data connection with the central server and the intelligent pharmacy module. In the event that a user using the wearable device is confirmed by the intelligent pharmacy module to have completed dispensing medication services, their departure route in the hospital two-dimensional map is determined by the central server. The departure route is set by the central server based on the flow rate of the person or other movable device as determined by the monitoring cameras in the path that the central server must travel through and in data connection with the central server.
PURPOSE: Inhaled mannitol induces bronchoconstriction and cough. This study aimed to describe the cough response to mannitol among healthy adult subjects.
METHODS: 125 healthy subjects (aged 18-82 years, 52% females, 50% skin prick test positive) underwent a mannitol test. The coughs were recorded both simultaneously and afterwards from video recordings by two researchers. Three indices were evaluated: The cumulative number of coughs per cumulative dose of mannitol (CDR), cumulative provocative dose of mannitol to cause at least 5 coughs, and the maximal number of coughs provoked by any single mannitol dose. The test was repeated in 26 subjects after 3-7 days.
RESULTS: CDR showed the best repeatability with an intraclass correlation coefficient of 0.829. Gender was the only characteristics that associated with the cough response: The median CDR was 2.53 (interquartile range 0.45-7.01) coughs/100 mg among females and 0.787 (0.0-3.29) coughs/100 mg among males (p = 0.002). The interquartile range upper limits were defined as the cut-off limits for a normal response. The threshold for a statistically significant change in CDR was 6.26 coughs/100 mg. There was a close correlation between simultaneous- and video-assessed CDR (intraclass correlation coefficient 0.985).
CONCLUSION: Females cough more than males in response to mannitol. CDR is the most suitable index to describe the cough responsiveness. The repeatability of the response is good. Video recording of the coughs is not mandatory. The cut-off limits for a normal cough response to mannitol were provided.
Eligible patients were switched from the comparator ERYPO®, to epoetin alfa HX575 Hexal AG in ratio 2:1 to be intravenously treated with HX575 in pre-filled syringes for 24 weeks (solution for injection i.v.). The maximum weekly dose was 300 UI/kg body weight (given 1 to 3 times) to maintain hemoglobin levels between 10-13 g/dL.
The invention belongs to the technical field of preparation of animal vaccines and particularly relates to a trivalent inactivated vaccine for Streptococcus equi subsp. zooepidemicus, Streptococcus suis serotype 2 and Streptococcus suis serotype 7, as well as a preparation method and application thereof. The inactivated vaccine disclosed by the invention is mainly applicable to prevention and treatment of swine Streptococcosis for sows, boars and piglets. The invention discloses separation, identification and application of three strains special for preparing the swine Streptococcosis trivalent inactivated vaccine, wherein the three strains for the vaccine are respectively a Streptococcus suis serotype 2-LT strain (with the collection number being CCTCC NO:M2011282), a Streptococcus suis serotype 7-YZ strain (with the collection number being CCTCC NO:M2011160) and a Streptococcus equi subsp. Zooepidemicus XS strain (with the collection number being CCTCC NO:M2011405). The inactivated vaccine disclosed by the invention can achieve multiple prevention effects with one injection, so that the stresses of swine are reduced, and the inactivated vaccine is safe and reliable and is free from the potential hazards of toxin spreading.
Major depressive disorder (MDD) is characterized by psychomotor retardation whose underlying neural source remains unclear. Psychomotor retardation may either be related to a motor source like the motor cortex or, alternatively, to a psychomotor source with neural changes outside motor regions, like input regions such as visual cortex. These two alternative hypotheses in main (n = 41) and replication (n = 18) MDD samples using 7 Tesla MRI are investigated. Analyzing both global and local connectivity in primary motor cortex (BA4), motor network and middle temporal visual cortex complex (MT+), the main findings in MDD are: 1) Reduced local and global synchronization and increased local-to-global output in motor regions, which do not correlate with psychomotor retardation, though. 2) Reduced local-to-local BA4 - MT+ functional connectivity (FC) which correlates with psychomotor retardation. 3) Reduced global synchronization and increased local-to-global output in MT+ which relate to psychomotor retardation. 4) Reduced variability in the psychophysical measures of MT+ based motion perception which relates to psychomotor retardation. Together, it is shown that visual cortex MT+ and its relation to motor cortex play a key role in mediating psychomotor retardation. This supports psychomotor over motor hypothesis about the neural source of psychomotor retardation in MDD.
PURPOSE: A composition containing purified extract or fraction of Mountain Cultivated Ginseng Radix is provided to suppress cetylcholinesterase activity and to prevent and treat brain diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating brain diseases contains purified extract or fraction of Mountain Cultivated Ginseng Radix leaves as an active ingredient. The brain diseases are amnesia, Lewis body disease, Pick's disease, Alzheimer's disease, stroke, Parkison's disease, or Huntington's disease. The fraction contains a purified material which is prepared by Kiesel gel column chromatography using chloroform and methanol. A health food for preventing and treating brain disease contains the extract or fraction as an active ingredient. The health food is powder, granule, tablet, capsule, syrup, or beverage.
PURPOSE:To obtain an easily available and inexpensive antiviral agent, by inoculating a culture medium consisting essentially of blackstrap sugar cane molasses with mycelia of an edible mushroom belonging to basidiomycetes, and cultivating the mycelia by the submerged culture method. CONSTITUTION:Mycelia of an edible mushroom, e.g. SHIITAKE mushroom, Pleurotus ostreatus Quel., Flammulina velutipes, Pholiota nameko, Lyophyllum agrregatum, etc. are inoculated into a culture medium consisting essentially of blackstrap sugar cane molasses, preferably a liquid culture medium diluted with water, and cultivated by the shaking culture or culture method with aeration at 15-30 deg.C for about 10 days. The mycelia multiply sufficiently to decompose partially heteroglicans contained in the blackstrap sugar cane molasses by many kinds of carbohydrase and expose active groups. After completing the cultivation, the mycelia are separated from the culture fluid, which is then concentrated and passed through a germfree filter, etc. to give the aimed liquid antiviral agent. EFFECT:Operation such as extraction of active constituents are remarkably simplified, and the very safe substance causes no problem, e.g. side effect, at all.
Patients with SLE according to the 1997 ACR, 2012 SLICC or 2019 EULAR/ACR criteria will undergo MRI along with neuropsychological tests, rheumatological evaluation and blood sample collection at baseline and after at least 12 months or during a new neuropsychiatric manifestation. In case of existing MRI with compatible features, they will be used as baseline studies.
The present disclosure relates to, inter alia, a method of making a whipped formulation and the formulation. The method comprises: selecting an amount of a gas propellant co-mingled with one or more active agents. The gas propellant is dispersed in the formulation, and the formulation is filled under pressure into a package, which may be pressurized. The package has a selected amount of pressure (“pre-gas or cut-bag pressure”). The pressure maintains the gas propellant dispersed in the formulation and the pressurized package is under sufficient pressure such that the formulation may be expelled as a whipped formulation upon application of external force on said formulation in said package. The whipped formulation is characterized by providing a desired sensory impact to a user.
Intraoperative hemorrhage is an important factor affecting intraoperative safety and postoperative patient recovery in percutaneous nephrolithotomy (PCNL). This study aimed to identify the factors that influence intraoperative hemorrhage during PCNL and develop a predictive nomogram model based on these factors.A total of 118 patients who underwent PCNL at the Department of Urology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from January 2021 to September 2023 was included in this study. The patients were divided into a hemorrhage group (58 cases) and a control group (60 cases) based on the decrease in hemoglobin levels after surgery. The clinical data of all patients were collected, and both univariate analysis and multivariate logistic regression analysis were conducted to identify the independent risk factors for intraoperative hemorrhage during PCNL. The independent risk factors were used to construct a nomogram model using R software. Additionally, receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA) were utilized to evaluate the model.Multivariate logistic regression analysis revealed that diabetes, long operation time and low psoas muscle mass index (PMI) were independent risk factors for intraoperative hemorrhage during PCNL (P < 0.05). A nomogram model was developed incorporating these factors, and the areas under the ROC curve (AUCs) in the training set and validation set were 0.740 (95% CI: 0.637-0.843) and 0.742 (95% CI: 0.554-0.931), respectively. The calibration curve and Hosmer-Lemeshow test (P = 0.719) of the model proved that the model was well fitted and calibrated. The results of the DCA showed that the model had high value for clinical application.Diabetes, long operation time and low PMI were found to be independent risk factors for intraoperative hemorrhage during PCNL. The nomogram model based on these factors can be used to predict the risk of intraoperative hemorrhage, which is beneficial for perioperative intervention in high-risk groups to improve the safety of surgery and reduce the incidence of postoperative complications.
BACKGROUND: Obesity is one of the most common health problems worldwide. Although studies have reported associations between adverse childhood experiences (ACEs) and obesity, specific subtype associations and sex differences are unclear.
OBJECTIVE: To systematically evaluate the association between ACEs and adult obesity risk and sex differences.
METHODS: Five databases, PubMed, Web of Science, Cochrane Library, Embase, and PsycINFO, were searched with a June 10, 2024 deadline. Included studies investigated the association between at least one ACE and obesity. Two researchers independently assessed the risk of bias using the Newcastle-Ottawa Scale (NOS) and its adaptations and extracted relevant characteristics and outcomes. Statistical analyses were performed using STATA 17.0, including random effects models, heterogeneity tests, sensitivity analyses, publication bias assessments, Meta-regression analyses, and subgroup analyses. Dose-response analyses revealed potential trends between different levels of abuse and risk of obesity.
RESULTS: The meta-analysis included 46 studies and showed a notable increased risk of obesity in adults experiencing ACEs (OR: 1.48, 95% CI: 1.38-1.59). Subgroup analyses showed significantly increased risk in Europe and North America, with significant increases observed in both developed and developing countries. Prospective, retrospective, and cross-sectional studies showed strong associations. Different types of ACEs (physical, sexual, psychological, and non-physical, psychological, or sexual abuse) were linked to a higher obesity risk. Sex difference analyses showed that females faced a greater risk when experiencing physical (OR: 1.606), sexual (OR: 1.581), and non-physical, psychological, or sexual (OR: 1.319) abuse; males exhibited increased risk only with non-physical, psychological, or sexual abuse (OR: 1.240). Dose-response analyses indicated that a higher number of ACEs was associated with an increased risk of obesity in adults.
CONCLUSIONS: ACEs significantly increase the risk of adult obesity, with consistent findings across geographic regions, levels of economic development, and types of study design. Sex difference analysis indicates that females are particularly affected. Future research should prioritize including studies from underrepresented geographic areas to enhance understanding of the global impact of ACEs on obesity risk. Additionally, strengthening child protection and intervention efforts is crucial to mitigate the adverse effects of ACEs on adult health.
Kidney stones pose a significant healthcare burden worldwide. Dyslipidemia is a risk factor for kidney stones, but the relationship between remnant cholesterol (RC) and kidney stone risk is unknown. We aimed to investigate the association between RC and the risk of incident kidney stones. We conducted a nested case-control study based on data from Shanghai Kidney Stone Cohort conducted in Shanghai from December 2018 to February 2023. Propensity score matching was used to select 2550 incident kidney stone cases and 7650 controls from a total of 60,158 adults. Baseline fasting plasma samples were collected to measure RC, which was calculated as total cholesterol minus high-density lipoproteins cholesterol and low-density lipoproteins cholesterol. Multivariable conditional logistic regression and a restricted cubic spline were used to estimate the association between tertiles of RC and kidney stone risk. Subgroup and sensitivity analyses were also performed. The baseline RC of incident kidney stone cases and controls were 0.58 (0.57) and 0.54 (0.55), respectively. Incident kidney stones had much higher baseline RC levels than controls (P < 0.001). Higher baseline RC levels were significantly associated with increased kidney stone risk after adjustment for potential confounders (highest vs. lowest tertile: OR 1.16, 95% CI 1.04-1.30; per 1 mmol/L increase: OR 1.16, 95% CI 1.07-1.26). Restricted cubic spline showed a significant positive and linear dose-response relationship between RC and the risk of developing kidney stones (P-overall = 0.005, P-nonlinear = 0.482). Sensitivity analyses yielded consistent results. Elevated RC levels are associated with a greater risk of incident kidney stones in Chinese adults.
A cannabidiol (CBD) preparation for use in the treatment of seizures associated with bilateral mesial temporal sclerosis (hippocampal sclerosis) is provided. The seizures associated with bilateral mesial temporal sclerosis may be tonic, tonic-clonic and focal seizures with secondary generalisation. The CBD preparation may comprise greater than or equal to 98% (w/w) CBD and less than or equal to 2% (w/w) other cannabinoids. The CBD preparation may comprise CBD isolated from cannabis plant material or may be synthetic CBD. The CBD preparation may be used in combination with one or more concomitant anti-epileptic drugs (AED). The one or more concomitant AEDs may be either oxcarbarmazepine or phenobarbital. The dose of CBD may be between 5 mg/kg/day to 50 mg/kg/day. A clinical trial is disclosed wherein a patient diagnosed with bilateral mesial temporal sclerosis had a decrease in the amount of tonic, tonic-clonic and focal seizures secondary generalisation after dosing with the CBD preparation and concomitant AEDs.
Gingival wound healing plays a critical role in maintaining oral health. However, this process can be delayed by oxidative stress and excessive inflammatory responses. In this study, we established a human inflammatory gingival tissue equivalent (iGTE) to investigate the inhibitory effects of hydrogen-rich water (HW), enzyme-digested edible bird's nest (EBND) and sialic acid (SA) on PMA (an inducer of oxidative free radicals)- and LPS (an inflammatory stimulus)-impaired wound healing. The iGTE was constructed by human gingival fibroblasts (hGFs), keratinocytes and macrophages under three-dimensional conditions. Wounds in the iGTE and hGF/keratinocyte monolayers were created by mechanical injury. Tissues and cells were pretreated with HW, EBND, and SA, and then exposed to the inflammatory and oxidative environment induced by PMA (10 ng/mL) and LPS (250 ng/mL). The inflammatory cytokines IL-6 and IL-8 were quantitatively analyzed by ELISA. Histopathological image analysis was performed by HE and immunofluorescence staining. In the iGTE, PMA/LPS significantly reduced the epithelial thickness while causing a decrease in K8/18, E-cadherin, laminin and elastin expression and an increase in COX-2 expression along with ulcer-like lesions. In mechanically scratched hGFs and keratinocyte monolayers, PMA/LPS significantly impaired wound healing, and promoted the secretion of IL-6 and IL-8. Pretreatment of HW, EBND, and SA significantly suppressed PMA/LPS-induced wound healing delay and inflammatory responses in cell monolayers, as well as in the iGTE. Remarkably, the combined use of HW and EBND exhibited particularly robust results. Combined use of HW and EBND may be applied for the prevention and treatment of wound healing delay.
The invention relates to the use of 2,5-dihydroxybenzenesulphonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforementioned compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases which present a reduction in apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapoptotic capacities thereof, in the treatment of chronic psoriatic plaques. ® KIPO & WIPO 2007
<P>PROBLEM TO BE SOLVED: To provide compositions and methods for modulating immune system.  <P>SOLUTION: The invention relates to compositions and methods for modulating immune system. One aspect of the invention relates to the compositions comprise FADD (fas-associated death domain molecule) -dependent signaling pathway modulators. Another aspect of the invention relates to the method of making biodegradable microparticles, such as a chitosan microparticle, or PLGA/PEI microparticle, designed to deliver nucleic acids and/or proteins, such as FADD-dependent signaling pathway modulators, to boost different pathways of an immune response. The further aspect of the invention relates to the use of the chitosan and other polycationic microparticles to deliver FADD-dependent signaling pathway modulators to modulate immune system for the prevention and/or treatment infectious diseases and cancers.  <P>COPYRIGHT: (C)2011,JPO&INPIT
The present invention provides a method for controlling crown gall disease in plants using an effective quantity of α-proteobacteria that produces trifolitoxin (TFX). The present invention also provides a biocontrol agent for use in the above method, and a plant coated with the biological control agent. The biocontrol agent is characterized as a biologically pure culture of an α-proteobacteria strain that produces TFX, or an α-proteobacteria strain genetically engineered to produce TFX. The α-proteobacteria strain employed may include any one of the many strains of  Agrobacterium  capable of producing crown galls, including  Agrobacterium vitis  and, in particular,  A. vitis  F2/5. The α-proteobacteria strain employed may be genetically engineered to produce TFX by introducing a genetic construct into the  Agrobacterium  so as to cause the  Agrobacterium  to carry and express the tfx operon from  Rhizobium . The bacteria may also be genetically engineered to produce TFX by introducing a pT2TFXK plasmid into the  Agrobacterium . The biocontrol agent may also be the strain  Agrobacterium vitis  F2/5 (pT2TFXK), ATCC Patent Deposit Designation PTA-2356.
PURPOSE:To form the title thin org. film uniformly contg. a heavy metal in the whole film, by incorporating a heavy metal deposited by photoreduction reaction into the inside and/or the surface of the thin org. film. CONSTITUTION:The heavy metal deposited by photoreduction reaction is incorporated into the inside and/or the surface of the thin org. film. The film of an org. molecule having a hydrophilic terminal and a hydrophobic terminal and formed by the Langmiur-Blodgett's technique or the high molecular film of liposome, etc., capable of being formed from an aq. soln. can be exemplified as the thin org. film. Concretely, a long-chain fatty acid film, a phosphatide film, a high molecular film having a donor and an acceptor molecule at the side chain, etc., can be exemplified. Gold, silver, copper, platinum, indium, etc., can be exemplified as the heavy metal. As a result, the concn. of the heavy metal is controlled under extremely mild conditions without destroying the structure of the thin org. film, and the thin org. film uniformly contg. a heavy metal can be formed.