anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:The titled food consisting essentially of powder and/or extract of Evoida rutaecarpa Hook f. et Thomson. CONSTITUTION:A hair growth and hair tonic food obtained by extracting dried leaf, root, seed or fruit or dried powder of Evoida rutaecarpa Hook f. et Thomson (used as a herb medicine; pepti, diuretic or analgesic, prepared by drying an unripe or ripe fruit of Evoida rutaecarpa Hook f. et Thomson or Evoida rutaecarpa Benth var. officinolis Huang which is a plant of the family Rutaceae) with water or a hydrous lower alcohol preferably under heating or concentrating to give a freeze-died powder. The food is capable of promoting the blood circulation, suppresses the formation of lipoperoxides, and preventing the retention of the so-called vitiated blood near the hair root, and exhibiting the effect by extending the nutriment to the hair. One or more of other compounding agents, e.g. Polygoni multiflori radix, Chinese jujube, Coicis semen, ginseng or safflower, therein.
PURPOSE:An antimutagenic agent, containing a vitamin B complex selected from thiamine pyrophosphate, folic acid and nicotinic acid as an active constituent, and capable of preventing mutagenicity caused by reaction of vitamin C with table luxuries or copper ions. CONSTITUTION:An antimutagenic agent containing a vitamin B complex selected from thiamine pyrophosphate (hereinafter abbreviated to TPP), folic acid and nicotinic acid as an active constituent. TPP which is a diphosphoric acid ester of thiamine (vitamin B1) and essential to the oxidative decarbonation and decomposition reaction of alpha-keto acids and folic acid, etc. are found to be capable of preventing the mutagenicity caused by vitamin C and usable as an antimutagenic agent. Thus, mutagenicity increased by reaction of coffee, black tea, tobacco, etc. with the vitamin C can be suppressed by mixing the above-mentioned vitamin B complex with the vitamin C.
The goal of this research study is to investigate the relationships among late-life depression (LLD), cognitive impairment and progressive neurodegeneration. The guiding hypothesis is that LLD patients have evolving cognitive impairments as a consequence of distinct underlying neuropathological changes, which frequently are expressed as Mild Cognitive Impairment (MCI). These neuropathological and cognitive changes are risk modifiers, lowering brain reserve capacity, and in turn, increasing risk of developing Alzheimer's Disease (AD). In order to pursue this goal we will enroll LLD, MCI, and normal control subjects to enrich our existing cohort to include a total of 150 elderly, non-demented, non-depressed subjects, 60 non-depressed MCI subjects and 270 LLD subjects. Using the joint infrastructure of the University of Pittsburgh's Advanced Center for Intervention and Services Research for Late-Life Mood Disorders and the Alzheimer's Disease Research Center, we will complete a detailed neurobehavioral evaluation, including clinical, neuropsychological, neuroimaging and biological markers, using these data to evaluate the factors associated with the development of MCI or dementia. Subjects will be studied annually for at least three years, allowing us to use longitudinal data to evaluate a series of linked hypotheses that postulate the pathways by which elderly, depressed patients develop cognitive impairment, and which may lead some to develop dementia.
BACKGROUND: Bloody urine is classified in farm animals as hematuria, hemoglobinuria, and myoglobinuria. In small ruminants, discolored urine is reported due to several etiologies which is sometimes fatal. Of these causes are babesiosis, bacillary hemoglobinuria, copper toxicity, and hypophosphatemia.
AIM: This study was designed to investigate the clinical, etiological, hematobiochemical, ultrasonographic, and pathological findings in rams and bucks with red urine syndrome.
METHODS: Eighteen male animals (nine rams and nine bucks) of 6 months to 3 years were examined. Parallel, 10 healthy controls were used. They were admitted due to red urine, voiding of only urine drops, straining during the act of urination, grunting during urination, ventral abdominal edema, and abdominal distension. The duration of the disease ranged from 2 to 30 days. A history of chronic copper toxicosis was informed in two bucks and a ram. Two blood samples were collected from diseased as well as from controls in EDTA tubes (for complete blood count testing) and in plain tubes (for serum collection).
RESULTS: Hematuria was found in 11 animals (seven bucks and four rams) while hemoglobinuria was detected in seven animals (five bucks and two rams). Sonographic findings in diseased animals included ruptured urinary bladder in 3, ruptured urethra in 5, penile calculi, uroperitoneum in 6, distended urinary bladder in 7, hydronephrosis in 5, echogenic deposits in the bladder in 3, and ventral urine accumulation in four animals. Laboratory evaluation of a Geimsa-stained blood smear confirmed the infection with Babesia in three bucks and a ram. Hemolytic anemia was marked in two bucks and a ram due to chronic copper toxicity. Biochemical abnormalities included hypoalbuminemia, hyperglobulinemia, increased blood urea nitrogen and creatinine concentration, and hyperglycemia. Postmortem examination was carried out on six animals (four rams and two bucks).
CONCLUSION: Discolored urine in rams and bucks in this study resulted from hematuria due to urinary calculi and pelvic abscessation or from hemoglobinuria due to Babesia infection or due to copper toxicity. Hemolytic anemia was the outstanding hematological finding and hypoalbuminemia, hyperglobulinemia, increased blood urea nitrogen (BUN) and creatinine, and hyperglycemia were the characteristic biochemical findings. Sonography of the urinary tract was very helpful in assessing the renal parenchyma, urinary bladder, and abdominal cavity for the verification of urolithiasis, hydronephrosis, intact or ruptured urinary bladder, uroperitoneum, and perforated urethra.
PURPOSE:To call upon the others to act in such a manner not to disturb sleep of a sleeping person so that a sleeping person can sleep quietly by detecting the sleeping condition of a sleeping person and informing the others of the detected sleeping condition. CONSTITUTION:When the body movement is caused in a sleeping person on a bed 13, a piezoelectric element 2 is subjected to deformation to generate the voltage. Only the frequency components of about 1-10Hz of the signal waveform of an output signal of the piezoelectric element 2 are passed by a filter circuit 3, amplified by an amplification circuit 4, rectified by a rectifying circuit 5 and then integrated by an integrating circuit 6. In a comparing circuit 8, if an output signal of the integrating circuit 6 is between Va and Vb, an output signal is Hi-level. If the output singal of the comparing circuit 8 is Hi- level, a timer 9 operates clocking. In a decision circuit 10, when the time counted by the time 9 amounts to a preset value, for example, more than 15min, it is judged that a human body on a bed enters sleeping, an output signal becomes Hi-level. When an output signal of the decision circuit 19 is Hi-level, an informing means 11 informs the others of the condition where a sleeping person is at present in the state of entering sleeping.
BACKGROUND: Cerebrospinal fluid rhinorrhea is a rare condition characterized by the abnormal leakage of cerebrospinal fluid from the intracranial space into the sinonasal cavity. It includes various etiologies, including traumatic, iatrogenic, and spontaneous causes, each with distinct epidemiological and clinical characteristics.
CASE PRESENTATION: A 40-year-old Asian female presented with a three-month history of watery discharge from her left nostril and dull headaches localized to the left side of her head. Despite the initial diagnosis of allergic rhinitis, symptoms persisted, leading to further evaluation and eventual diagnosis of cerebrospinal fluid rhinorrhea. Detailed history, physical examination, and diagnostic tests including fluid analysis and imaging confirmed the diagnosis. The patient underwent a successful surgical repair after failed conservative management, highlighting the importance of timely intervention.
CONCLUSION: Cerebrospinal fluid rhinorrhea poses significant risks if left untreated, including meningitis. Prompt recognition, accurate diagnosis, and individualized treatment strategies are crucial in mitigating complications and improving patient outcomes. A multidisciplinary approach, incorporating both conservative and surgical interventions tailored to the underlying cause, is essential for the successful management of cerebrospinal fluid rhinorrhea.
Hemophagocytic lymphohistiocytosis (HLH) comprises a broad spectrum of life-threatening cytokine storm syndromes, classified into primary (genetic) or secondary (acquired) HLH. The latter occurs in a variety of medical conditions, including infections, malignancies, autoimmune and autoinflammatory diseases, acquired immunodeficiency, and metabolic disorders. Despite recent advances in the field, the pathogenesis of secondary HLH remains incompletely understood. Considering the heterogeneity of triggering factors and underlying diseases in secondary HLH, a large diversity of animal models has been developed to explore pivotal disease mechanisms. To date, over 20 animal models have been described that each recapitulates certain aspects of secondary HLH. This review provides a comprehensive overview of the existing models, highlighting relevant findings, discussing the involvement of different cell types and cytokines in disease development and progression, and considering points of interest toward future therapeutic strategies.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely endocrinology and therapy. Diabetes control system is used to control diabetes, which includes glucometers, an insulin pump and a microcontroller. Using the meter for incidental measurement of glucose in a patient's liquid sample, a glucose concentration level is obtained in the form of input data for bolus calculation. Using glucometer for continuous measurement of glucose level in patient through uniform time intervals glucose concentration is determined for each interval in the form of glucose measurement data, which can be used for bolus calculation. Infusion insulin pump is used to deliver insulin into the patient's body. Microcontroller is configured to provide a bolus recommendation for the patient, to assess whether the actual bolus delivered by the pump is different from the bolus recommendation. If the delivered actual bolus is different from the bolus indicating the downward trend or to increase the rate of glucose change for a certain period of time after the bolus delivery relative to a predetermined downward trend threshold or a predetermined upward trend threshold, and informing the user on a downward trend or increasing the values along with the actual bolus delivered into the body, and the bolus recommendation.EFFECT: disclosed is post-bolus administration for treating diabetes.1 cl, 5 dwg
PURPOSE:To obtain extremely fine and uniformly pulverized powder, especially flake fine powder, at a relatively low cost without causing denaturation of keratin, by pulverizing animal fur, human hair, bird's feather, etc., using a circulation vacuum pulverization technique. CONSTITUTION:A vacuum pulverization apparatus (Japanese Patent Publication No.52-11787) is improved to replace a hammer and a protrusion with a rotary edge and a stationary edge and connect the outlet of a pulverized material container with an inlet of a container of the object to be pulverized, thereby enabling the circulated pulverization in vacuum. Animal fur preliminarily defatted with an organic solvent (e.g. diethyl ether, acetone, etc.), etc., is pulverized in a vacuum of 2-30mmHg, preferably 2-10mmHg while circulating 2-10 times, preferably 3 times. The powder is classified with a classifier, preferably a forced vortex centrifugal classifier to obtained fine powder having an average major diameter of <=30mum and an aspect ratio of >=4.
BACKGROUND: Social support is widely recognized as a protective factor against psychological distress, especially for the elderly with chronic diseases. Therefore, effective tools for measuring social support are of great significance for both research and clinical practice. This study aims to cross-culturally adapt the German Social Support Scale (F-SozU) into Chinese and assess its psychometric properties among older adults with chronic diseases.
METHODS: A cross-sectional study was conducted in a Chinese tertiary hospital. Four hundred ninety-six older adults that were approached via a convenience sampling method completed the Chinese version of the F-SozU. Content validity was evaluated using the two-round Delphi method. Psychometric properties, including item analysis, content validity, structure validity, convergent and discriminant validity and reliability were examined.
RESULT: The final version of C-F-SozU is a three-factor structure consisting of 23 items. All indicators of item analysis are acceptable. Adequate content validity was ensured by the expert panel (I-CVI = 0.80-1.00, S-CVI = 0.965) and participants. The confirmatory factor analysis model revealed that the factor structure of the C-F-SozU fitted the original scale (χ 2 /df = 2.088, CFI = 0.998, GFI = 0.943, TLI = 0.997, IFI = 0.998, RMSEA = 0.064 and SRMR = 0.043). The total Cronbach's α was 0.956, and the test-retest reliability coefficient was 0.887. The convergent validity (average variance extracted = 0.517-0.995) and discriminant validity were found to be satisfactory. No floor/ceiling effect was found.
CONCLUSION: The 23-item C-F-SozU demonstrates robust reliability and validity, rendering it a valuable instrument for evaluating social support among older adults with chronic diseases in China. The three-factor structure of the scale allows for a more detailed assessment of the social support, with the scores of each dimension and the total score being of significant reference value. More comprehensive studies may be required to confirm its effectiveness and applicability.
Chronic oral inflammation and biofilm-mediated infections drive diseases such as dental caries and periodontitis. This study investigated the anti-inflammatory and antibacterial potential of an ethanol extract from Astilbe chinensis inflorescence (GA-13-6) as a prominent candidate for natural complex substances (NCS) with therapeutic potential. In LPS-stimulated RAW 264.7 macrophages, GA-13-6 significantly suppressed proinflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and nitric oxide (NO), surpassing purified astilbin, a known bioactive compound found in A. chinensis. Furthermore, GA-13-6 downregulated the expression of cyclooxygenase-2 (COX2) and inducible nitric oxide synthase (iNOS), indicating an inhibitory effect on the inflammatory cascade. Remarkably, GA-13-6 exhibited selective antibacterial activity against Streptococcus mutans, Streptococcus sanguinis, and Porphyromonas gingivalis, key players in dental caries and periodontitis, respectively. These findings suggest that complex GA-13-6 holds the potential for the treatment or prevention of periodontal and dental diseases, as well as various other inflammation-related conditions, while averting the induction of antibiotic resistance.
The recommended dosages for adults and pediatric patients 1 month of age and older are included in Table 1. Administer the total daily dosage orally in two or three divided doses as indicated in Table 1. In pediatric patients, the recommended dosing regimen is dependent upon body weight. Based on clinical response and tolerability, dosage may be increased, approximately weekly.

Both the efficacy and adverse event profiles of LYRICA have been shown to be dose-related.

The effect of dose escalation rate on the tolerability of LYRICA has not been formally studied.

The efficacy of adjunctive LYRICA in patients taking gabapentin has not been evaluated in controlled trials. Consequently, dosing recommendations for the use of LYRICA with gabapentin cannot be offered.
BACKGROUND: Posterior urethral valves (PUV) is the most common cause of obstructive uropathy in boys; approximately 15% develop kidney failure by early adulthood. However, rates of kidney function decline are poorly defined in PUV children and adults, as is the impact of potentially modifiable chronic kidney disease (CKD) progression risk factors.
METHODS: We conducted a retrospective review of all PUV patients followed at our institution from 1995 to 2018. Inclusion criteria were estimated glomerular filtration rate (eGFR) > 20 ml/min/1.73 m2 after 1 year of age, no dialysis or kidney transplant history, and ≥ 2 yearly serum creatinine values after age 1 year. eGFRs were calculated using creatinine-based estimating formulas for children (CKID U25) or adults (CKD-EPI). The primary outcome was annualized change in eGFR, assessed with linear mixed effects models. We also examined the association of acute kidney injury (AKI), proteinuria, hypertension (HTN), and recurrent febrile urinary tract infections (UTIs) with eGFR decline.
RESULTS: Fifty-two PUV patients met the inclusion criteria. Median (interquartile range) eGFR decline was 2.6 (2.1, 3.1) ml/min/1.73 m2/year. Children (n = 35) and adults (n = 17) demonstrated progressive decline. Proteinuria and recurrent UTIs were significantly associated with faster progression; AKI and HTN were also associated but did not reach significance.
CONCLUSION: PUV patients show progressive loss of kidney function well into adulthood. Proteinuria and recurrent UTIs are associated with faster progression, suggesting potential modifiable risk factors. This is the first study to report annualized eGFR decline rates in PUV patients, which could help inform the design of clinical trials of CKD therapies.
Run-out Phase: Following completion of the 6-week treatment phase, participants in this group were administered filorexant 10 mg once daily at bedtime for 2 weeks. Participants in this group had received filorexant 10 mg once daily during the treatment phase.
FIELD: medicinal and food industry. SUBSTANCE: consortium is prepared by combination of bifidobacterium of the following six strains: B. bifidum 791, LVA-3, B. longum YA-3, B. breve 79-88, B. infantis 79-43, B. adolescentis G 7513. The proposed consortium of bifidobacterium strains multiplies actively in nutrient media and accumulates industrial biomass for short culturing periods, ferments milk, forms clot with good taste and organoleptic properties and shows specific activity. Consortium of strains can be recommended as component for ferments in preparing fermented-milk curative-dietetic foodstuffs, nonfermented foodstuffs, bacterial preparations and biologically active supplements. Consortium shows the enhanced specific activity, it is able for the more rapid adaptation in intestine and promotes to normalization of intestine microflora for more early times. Obtainable curative- prophylactic foodstuffs show the enhanced organoleptic properties. EFFECT: improved method of preparing, valuable biological and medicinal properties.
OBJECTIVE: The occurrence of prostate hyperplasia has increased remarkedly, especially in elderly patients; However, research on which surgical treatment is effective and safe for benign prostatic hyperplasia (BPH) in elderly people over 70 years old is limited. This study aimed to investigate the clinical efficacy and safety of transurethral plasma kinetic prostatectomy (TUPKP) and holmium laser enucleation of prostate (HoLEP) as a therapy for benign prostatic hyperplasia (BPH) in the elderly.
METHODS: A total of 148 patients with BPH admitted from December 2022 to December 2023 were chosen and divided into HoLEP (n = 74) and TUPKP (n = 74) groups according to the surgical operation. Perioperative related indexes, preoperative and postoperative international prostate symptom scores and life quality scores were compared between the two groups. The postoperative complications were also counted for the two groups.
RESULTS: The HoLEP group had lower intraoperative bleeding, mean operative time, catheter indwelling time and hospital stays than the TUPKP group (p < 0.001). Before treatment, no significant difference in prostate symptom scores was found between the two groups (p > 0.05). After treatment, the prostate symptom scores in the HoLEP group were significantly lower than those in the TUPKP group (p < 0.001). However, the maximum urinary flow rate was significantly higher (p < 0.001) and the residual urine volume was significantly lower (p < 0.001) in the HoLEP group than in the TUPKP group after operation. The complication rate in the TUPKP group was 25.66%, which was significantly higher than the 9.46% in the HoLEP group (p < 0.05). The life quality scores of the HoLEP group were higher than those of the TUPKP group (p < 0.001).
CONCLUSIONS: HoLEP for BPH therapy is effective and safe with low incidence of postoperative complications.
Many hospitals have stopped or are considering stopping universal admission testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We discuss reasons why admission testing should still be part of a layered system to prevent hospital-acquired SARS-CoV-2 infections during times of significant community transmission. These include the morbidity of SARS-CoV-2 in vulnerable patients, the predominant contribution of presymptomatic and asymptomatic people to transmission, the high rate of transmission between patients in shared rooms, and data suggesting surveillance testing is associated with fewer nosocomial infections. Preferences of diverse patient populations, particularly the hardest-hit communities, should be surveyed and used to inform prevention measures. Hospitals' ethical responsibility to protect patients from serious infections should predominate over concerns about costs, labor, and inconvenience. We call for more rigorous data on the incidence and morbidity of nosocomial SARS-CoV-2 infections and more research to help determine when to start, stop, and restart universal admission testing and other prevention measures.
It will be offered to patients hospitalized in these 2 services and presenting post-resuscitation ICU-weakness, especially in the aftermath of COVID infection, to complete an acceptability questionnaire (a priori) concerning the use of a Virtual Reality tool intended to improve walking in the ICU. The duration of filling in this questionnaire is estimated at 30 minutes.
PURPOSE: A cosmetic composition containing rhapontin for UV protection is provided to block UV ray and to ensure antioxidation and anti-inflammation without side irritation. CONSTITUTION: A cosmetic composition for UV protection contains rhapontin as an active ingredient. A cosmetic composition for recovering damaged skin contains rhapontin as an active ingredient. A cosmetic composition for preventing and treating inflammation contains rhapontin as an active ingredient. Rhapontin is derived from Polygoni multiflori Radix. The cosmetic composition is used in the form of skin lotion, skin toner, astringent, lotion, milk lotion, moisture lotion, cleansing lotion, cream, hand cream, nutrition essence, pack, soap, shampoo, emulsion, and pressed powder.
The biweekly 5-fluorouracil and leucovorin (LV5FU2) regimen associated with oxaliplatin (FOLFOX) is active in patients with AGC. Meanwhile, Paclitaxel monotherapy is also active in patients with AGC. In previous studies, we found that POF(A combination of oxaliplatin, fluorouracil and Paclitaxel) regimen appears to be of good efficacy and is well tolerated in patients with advanced gastric cancer. This study is being done to find out if three drugs combination maintain manageable side effects but have better benefit than two drugs combination. Intraperitoneal paclitaxel showed high local concentration in abdominal cavity and low systemic toxicity. This study is being done to find out if the combination with Intraperitoneal paclitaxel and FOLFOX have higher local control rate and lower systemic toxicity.