anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Calorigenic plaster is prepd. by combining an oily mass of paraffin and mineral fats with a solid mass of finely powdered clay (e.g. bentonite) filler and powder from algae. Product combines the properties of all three constituents. The plaster is safe and simple to use. It may have medicaments on it for percutaneous use.
Examples may include a microsphere. The microsphere may include a biodegradable polymer. Furthermore, the microsphere may include a protein mixture selected from the group consisting of a protein-polyethylene glycol conjugate, the protein-polyethylene glycol conjugate and the hydrophobic anion of the organic acid, a protein and the hydrophobic anion of the organic acid, and combinations thereof. Examples may also include a method of making the microspheres. The method may further include reacting a polyethylene glycol with a protein to form a protein-PEG conjugate. In addition, the method may include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid to form the protein-PEG conjugate salt. Furthermore, the method may include mixing the protein-PEG conjugate salt in an organic solvent with a biodegradable polymer. The method may also include emulsifying the mixture. Additionally, the method may include hardening the emulsified mixture into the controlled-release microspheres.
Twenty adult individuals underwent a standard blood volume measurement. The specimens for this determination are normally collected over a period of approximately 40 minutes. For the determination of total body albumin, additional specimens were collect over a three to four day period until the counts in the blood specimens were stable. Calculation of the degree of dilution over this time interval is thought to represent dilution of the tracer in albumin in both the intra and extravascular space. The ratio of albumin in the intravascular to the extravascular space is available in the medical literature. The total volume in which the tracer is distributed can be determined from the dilution determined. A calculation of total body albumin is therefore possible. Computation of the total body albumin for the test subjects (all normal individuals) was consistent with values for total body albumin in the literature. The purpose of the development of this method is to permit clinicians to determine albumin status in patients with disturbances in albumin such as burn patients, cirrhotic patients, nephrotic patients as well as patients with protein losing gastroenteropathies.
Patients with ischemic and non-ischemic heart failure with indications for CRT. Assessment of cardiac sympathetic innervation by 123IMIBG CZT SPECT.
PROBLEM TO BE SOLVED: To accept a plurality of types of medical information with voice input, and to discriminate between those medical information by a simple operation.SOLUTION: The medical information processing system includes: an input part; a voice analysis part; a state detection part; a discrimination information storage part; and an association processing part. The input part accepts the medical information with voice input. The voice analysis part analyzes the accepted voice, and converts it into a character string. The state detection part detects each of the plurality of states of the input part. The discrimination information storage part preliminarily stores discrimination information in which each of the plurality of states is associated with the classifications of information constituting medical treatment records. The association processing part specifies the classification corresponding to the detected state on the basis of the discrimination information, and associates the information showing the specified classification with the character string obtained by converting the voice input.
Changes in biomarker levels of Alzheimer's disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti-amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints. Consensus methodology for assessing such relationships is lacking, leading to inconsistent evaluation and reporting. In this review, we provide a statistical framework for reporting treatment effects on early and late accelerating AD biomarkers and assessing their relationship with clinical endpoints at the subject and group levels. Amyloid positron emission tomography (PET), plasma p-tau, and tau PET follow specific trajectories during AD and are used as exemplar cases to contrast biomarkers with early and late progression. Subject-level correlation was assessed using change from baseline in biomarkers versus change from baseline in clinical endpoints, and interpretation of the correlation is dependent on the biomarker and disease stage. Group-level correlation was assessed using the placebo-adjusted treatment effects on biomarkers versus those on clinical endpoints in each trial. This correlation leverages the fundamental advantages of randomized placebo-controlled trials and assesses the predictivity of a treatment effect on a biomarker or clinical benefit. Harmonization in the assessment of treatment effects on biomarkers and their relationship to clinical endpoints will provide a wealth of comparable data across clinical trials and may yield new insights for the treatment of AD.
BACKGROUND: Differences between the bacterial culture results of the preoperative fluid, intraoperative tissue, and sonication fluid of implants in the diagnosis of periprosthetic joint infection (PJI) are important issues in clinical practice. This study aimed to identify the differences in pooled diagnostic accuracy between culture sample types for diagnosing PJI by performing a systematic review and meta-analysis.
METHODS: This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. A comprehensive literature search of PubMed, Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library databases was performed. Data extraction and study assessment using the quality assessment of diagnostic accuracy studies were performed independently by two reviewers. The pooled sensitivity, specificity, summary receiver operating characteristic curve, and area under the summary receiver operating characteristic curve were estimated for each sample type.
RESULTS: There were thirty-two studies that were included in the analysis after screening and eligibility assessment. The pooled sensitivities of preoperative fluid, intraoperative tissue, and sonication fluid for the diagnosis of PJI were 0.63 (95% confidence interval [CI] 0.56 to 0.70), 0.71 (95% CI 0.63 to 0.79), and 0.78 (95% CI 0.68 to 0.85), while the specificities were 0.96 (95% CI 0.93 to 0.98), 0.92 (95% CI 0.86 to 0.96), and 0.91 (95% CI 0.83 to 0.95), respectively. The area under the curves for preoperative fluid, intraoperative tissue, and sonication fluid were 0.86, 0.88, and 0.90, respectively.
CONCLUSIONS: Sonication fluid culture demonstrated better sensitivity compared with the conventional culture method, and preoperative fluid culture provided lower sensitivity in diagnosing PJI.
The invention discloses orally-taken powder with an intestinal canal cleaning function. The orally-taken powder is prepared from, by weight, 15-25 parts of Dendrobium officinale Kimura et Migo, 20-30 parts of Eleusine indica (L.) Gaertn, 25-35 parts of semen platycladi, 5-15 parts of Wedelia chinensis (Osbeck.) Merr., 30-40 parts of hawthorn, 25-35 parts of honey and 25-35 parts of xylo-oligosaccharide. A preparation method includes the steps of taking and mixing Dendrobium officinale Kimura et Migo, Eleusine indica (L.) Gaertn, semen platycladi, Wedelia chinensis (Osbeck.) Merr. and hawthorn, adding water, conducting decoction for 1.5-2.5 hours, conducting filtration to obtain liquid medicine, and adding honey and xylo-oligosaccharide to be evenly mixed, condensed and spray-dried to obtain the powder. By means of the powder, the environment of intestinal flora can be remarkably improved, peristalsis of intestines is promoted, intestinal canals can be smooth and not prone to blockage and harmful substance accumulation, and the powder is beneficial for cleanness of intestinal canals and can have the function of preventing and treating constipation for a long time.
PURPOSE: A case of BK nephropathy in a kidney transplant recipient who received an organ from a hepatitis C virus (HCV)-positive donor is reported.
SUMMARY: A 66-year-old male negative for HCV with chronic kidney disease secondary to diabetic glomerulosclerosis received a kidney transplant from an HCV-viremic donor. His initial postoperative course was uncomplicated, and HCV treatment with glecaprevir/pibrentasvir was initiated after discharge. On postoperative day (POD) 60, the patient developed BK viremia and his mycophenolate mofetil dose was decreased. Over the next few months, the BK viral load increased, with mycophenolate mofetil stopped and the tacrolimus goal lowered in response. On POD 130, the patient was admitted for a hypertensive crisis and found to have decreased renal function. During this hospitalization, the patient received a course of intravenous immune globulin (IVIG). Despite an initial response to the modification of immunosuppression therapy and several courses of IVIG over the following months, the patient's renal function continued to decline. At 18 months after transplantation, the patient was restarted on dialysis and taken off all immunosuppression.
CONCLUSION: Utilization of organs from HCV-positive donors in HCV-negative recipients allows for expansion of the donor pool and facilitates shorter times on the waitlist. Although initial data in HCV-discordant transplantation did not find an increased risk for opportunistic infections, more recent studies have shown that such risk may be present. This case report describes a patient who developed BK viremia and eventual allograft failure after an HCV-discordant transplantation.
Hepatic encephalopathy (HE) is a severe complication of TIPS treatment in patients with cirrhosis and variceal bleeding. The overall incidence of post-TIPS encephalopathy ranges between 10% and 50%, and even the percentage of the new or worsened HE was evaluated up to 13-36%. No approach or medication was evidenced for prophylaxis of post-TIPS encephalopathy, including lactulose and rifaximin. Diet management has been used as an important part of the prophylaxis and treatment strategy for patients with metabolic diseases like diabetes and nephritis, which has drawn increasing interest of clinicians. Nevertheless, there is still no standard consensus or even recommendation for patients after TIPS procedure for now, which worsened malnutrition and affected survival. Thus, this study is specially designed to explore whether diet management strategy, drawn up from the nutritional management consensus of hepatic encephalopathy (ISHEN consensus), could decrease incidence of encephalopathy after TIPS treatment of the patient with cirrhosis and variceal bleeding.
The aim of the study was to evaluate postoperative pain and radiographic evidence of periapical healing in teeth with apical periodontitis treated in a single visit with an additional final irrigation using 2% chlorhexidine and to compare the results with conventional multiple-visit root canal treatment (RCT) with an intracanal calcium hydroxide dressing as a control group. Ninety asymptomatic maxillary anterior teeth with periapical lesions were treated by a single operator using the step-back technique with manual instrumentation with 2.5% sodium hypochlorite (NaOCl) and 5% ethylenediaminetetraacetic acid (EDTA) as irrigants. Half of the teeth were randomly assigned to the single-visit (SV) group and received an additional final rinse with 2% chlorhexidine (CHX) before obturation. The other teeth were treated in multiple visits (MV), after completion of root canal instrumentation calcium hydroxide paste was placed into the root canal and root canal obturation was performed in second visit. All patients were recalled and investigated clinically and radiographically for 24 months. Postoperative pain at 24-48 hours and changes in apical bone density indicating radiographic healing were evaluated statistically using the Mann-Whitney U-test followed by the Friedman and the Wilcoxon tests (α=.05).
1. Technical Result Increase in efficiency of treatment of conditions related with diabetes.         2. Essence A compound of the formula wherein R1 – R4 are disclosed in the description, pharmaceutically acceptable salts and tautomeric forms. Their use as antidiabetic agents, alone or in combination with other antidiabetic agents, such as sulfonilureas or biguanides, as well as for the treatment of complications associated to the resistance to the insulin, such as hypertension, hyperuricemia or other cardiovascular, metabolic, endocrine conditions; methods for their production and pharmaceutical compositions containing the same.         3. Field of Application Medicine.               Tables: 1
BACKGROUND AND AIMS: Recently, new indices combining routine and low-cost anthropometric and biochemical measurements have emerged. Among them, the visceral adiposity index (VAI) and lipid accumulation product (LAP) are being investigated for the prediction of altered blood pressure (BP) and insulin resistance (IR). Therefore, this study aimed to evaluate whether visceral adiposity index (VAI) and height-corrected lipid accumulation product (HLAP) are predictors of cardiometabolic risk in Brazilian adolescents.
METHODS AND RESULTS: Data were obtained from the Cardiovascular Risk in Adolescents (ERICA) study, a cross-sectional, national, multicenter, school-based survey conducted between 2013 and 2014 in Brazil. The sample consisted of 37,815 adolescents aged 12-17 years of both genders attending the last 3 years of elementary or secondary school from public and private schools located in 273 municipalities with more than 100,000 inhabitants. A Poisson regression was performed to verify associations between VAI and HLAP indices and the presence of altered BP and IR according to sex. In addition, receiver operating characteristic curve (ROC) analysis was applied to compare the predictive ability and determine the cut-off points of the VAI and HLAP indices in identifying cardiometabolic risk obtained by altered BP and IR. The prevalences of altered BP and IR were 24.49 % (95 % confidence interval [CI]: 23.14-25.87) and 24.22 % (95 % CI: 22.70-25.80), respectively.
CONCLUSIONS: The VAI and HLAP indices are good predictors of cardiometabolic risk in Brazilian adolescents. HLAP showed better performance in identifying insulin resistance in males.
Routine chemotherapy every 3 weeks for 2 cycles, and follow up for 2 weeks after discharge from hospital. Total observation duration is 6 weeks.
A composition containing a Rubus coreanum extract for anti-inflammation is provided to suppress the activationof NF-Kb, cyclooxygenase-2, and chondroitinase and inhibit the inflammation. A pharmaceutical composition for anti-inflammation comprises a Rubus coreanus extract as an active ingredient. The Rubus coreanus extract is obtained through the hot water extraction or methanol extraction. A daily dose of the composition is 1-30 mg/kg. The composition is used in a form of tablet, pill, granule, capsule, suspension, emulsion, syrup, insoluble solvent, freeze-dried preparation or suppository. A fermented milk, beverage, or health functional food for anti-inflammation comprises the Rubus coreanus extract which is isolated with a hot water as an active ingredient.
In patients undergoing hepatic resection for liver cancer (with cirrhosis or fibrosis liver), mortality rate can reach 10% and morbidity (ascites, icteria, infections) 70%. These complications are mainly due to hepatic insufficiency: surgery leaves a reduced parenchyma, with oxidative stress lesions due to reperfusion injury. A good preoperative nutritional state has been shown to reduce complications and mortality. This can be amplified by preoperative nutrition with supplements containing L-arginin, ω3 polyunsaturated fatty acids, and nucleotides which boost immune responses, resistance to infections and liver function recovery. In this context, the study randomly assigns 50 patients who were scheduled to undergo hepatic resection, to receive either an oral immune-enhancing nutritional supplement or a placebo, for the 7 last preoperative and the first 3 postoperative days. The aim of the study is to evaluate the effects of this supplementation on liver function, immunity, and incidence of infections after surgery.
A magnetic resonance (MR) image processing system is provided. The system includes an MR image processing computing device that includes at least one processor. The processor is programmed to execute a neural network model configured to receive crude MR data as an input and output processed MR images associated with the crude MR data, the crude MR data and the processed MR images having the first number of dimensions. The processor is also programmed to receive a pair of pristine data and corrupted data both having a second number of dimensions lower than the first number of dimensions. The corrupted data are the pristine data added with primitive features. The processor is further programmed to train the neural network model using the pair of the pristine data and the corrupted data. The trained neural network model is configured to change primitive features associated with the crude MR data.
Infuse diluted NPC-06 18mg/kg solution with 3 to 4 times volume of saline. Administarate NPC-06 gradually (slowly) over 18 minutes.
INTRODUCTION: In Chile, there is a high prevalence of obesity, and most people have an inadequate quality of food. Food environments can constitute barriers that prevent healthy food choices and lead to overweight and obesity, as well as diet-related non-communicable diseases. There are international instruments that allow the characterization of food environments. In Chile, there are no studies on the perception of food environments. This study aimed to characterize the perception of obesogenicity of food environments in the urban Chilean population using an instrument previously validated in Chile.
METHODS: This is a cross-sectional study with probabilistic sampling. The "Perceived Nutrition Environment Measures Survey", based on the Chilean model of food environments, was applied to 256 participants from two urban communities of the Metropolitan Region. Scores were calculated for the instrument items, which allowed calculating scores by environments included in the Chilean model of Food Environments. Negative scores were related to a higher obesogenic level.
RESULTS: The results show that the domestic food environment is perceived as less obesogenic (median of 15.8 points), with more than 90% of households having fruits, vegetables, and legumes, even though the supply food environment was negative (median -0.19 points). However, about 50% of households had ultra-processed foods. The street food environment was perceived as the most obesogenic (median -1.91 points), with more than 60% of the participants indicating difficulty finding healthy options.
CONCLUSIONS: According to the level of obesogenicity of the environments studied, it is necessary to have public policies that improve them and ensure the availability and physical and economic access to healthy food, particularly in the food supply and public road environments.
Natural product-like compounds are derived from the sesquiterpene lactone parthenolide. Methods are provided for the generation of novel natural product-like molecules obtained through the chemoenzymatic reelaboration and modification of the parthenolide scaffold. Structurally and skeletally diverse natural product-like compounds are synthesized via scaffold editing/rearrangement of 9(S)-hydroxy-parthenolide, 1,10-epoxy-parthenolide or 14-hydroxy-parthenolide. The compounds have demonstrated anticancer activity as measured based on reduction of cell viability upon incubation of the various cancer lines for 24 hours. These compounds may be used in pharmaceutical compositions as anticancer and anti-inflammatory agents. The compounds may also be used in a method of inhibiting cancer cell growth and metastasis of cancer cells.
NEW MATERIAL:A diamine platinum (II) complex of formula I [two Y bond with each other to form group of formula II (m is 1 or 2) or formula III; X is halogen or two X bond with each other to form group of formula IV or V (R1 and R2 are H or lower alkyl), etc.]. EXAMPLE:cis-Dichloro-1,1-bis(aminomethyl)-4-oxacyclohexane platinum. USE:An antineoplastic agent. It has extremely excellent antineoplastic activity, extremely low nephrotoxicity and high solubility in water. It is stable at room temperature and can be stored without using low-temperature storage facility. PREPARATION:A compound of formula I wherein X is halogen can be produced by reacting a tetrahalogenatoplatinum salt of formula M2Pt(Hal)4 (M is Na, K, etc.; Hal is halogen) with an amine of formula VI in water, preferably at room temperature -90 deg.C.
Since the use of non-nucleoside reverse transcriptase inhibitors such as U-87201E has been associated with the rapid development of resistant HIV isolates, an initial evaluation of this drug in patients was made in combination with AZT. Because of the inability to detect resistance after 6 weeks of combined AZT/U-87201E therapy, this protocol will initially investigate U-87201E administered alone and then investigate the effect of this drug with AZT and ddI or ddC.

Ten patients are treated at each of three targeted concentration ranges of U-87201E. Patients in the second cohort are enrolled immediately after patients in the first cohort are accrued; patients in the third cohort are enrolled when 5 of 10 patients in the second cohort have tolerated that dose for at least 4 weeks. The MTD will be the dose below that which produces dose-limiting grade 3 or 4 toxicity in five out of 10 patients. At least two women and five antiretroviral naive patients must be enrolled in each dose concentration range. Patients receive at least 8 weeks of monotherapy with U-87201E, with possible extension to at least 24 weeks with the same dose of U-87201E alone or in combination with zidovudine plus either ddI or ddC. Patients are followed weekly for at least 8 weeks and, if applicable, at weeks 10, 12, 16, 20, and 24 and monthly thereafter, up to 1 month following the last dose. Patients on combination therapy will have an indwelling venous catheter inserted for the first 2 days of combination therapy. Per 10/15/93 amendment, if no MTD is established with the first three cohorts, then 10 additional patients will be enrolled at a fourth concentration.
The invention belongs to the technical field of medicine, and relates to dibenzocyclooctene lignans shown as the general formula (I), microbial conversion products thereof and applications of the microbial conversion products in medicines used for treating and preventing microglia cell activation related diseases. The structures of the compounds can have three conformations: an S dibenzo configuration and a TBC octatomic ring conformation; an R dibenzo configuration and a TBC octatomic ring conformation; and an S dibenzo configuration and TB octatomic ring conformation. R1, R2, R3, R4, R5, and R6 are hydrogen, hydroxy, methoxy, angelate, acetate, benzoate, tigliate or ortho-methylenedioxy. R7 and R8 are hydrogen, hydroxy, methoxy, keto, angelate, acetate, benzoate and tigliate, and can form a ternary oxo bridge with an oxygen atom or form a macrolide with the R3 site and the R4 site. If the R7 and the R8 are chiral centers, the configuration can be S or R. R9, R10, R11 and R12 are hydrogen, methyl, hydroxy, keto or a double bond. If the R9, the R10, the R11 and the R12 are chiral centers, the configuration can be S or R. The formula (I) is shown in the specification.