anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
No specific information is available on the treatment of overdosage with montelukast sodium. In chronic asthma studies, montelukast has been administered at doses up to 200 mg/day to adult patients for 22 weeks and, in short-term studies, up to 900 mg/day to patients for approximately a week without clinically important adverse experiences. In the event of overdose, it is reasonable to employ the usual supportive measures; e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.   
There have been reports of acute overdosage in post-marketing experience and clinical studies with montelukast sodium. These include reports in adults and children with a dose as high as 1000 mg. The clinical and laboratory findings observed were consistent with the safety profile in adults and pediatric patients. There were no adverse experiences in the majority of overdosage reports. The most frequently occurring adverse experiences were consistent with the safety profile of montelukast sodium and included abdominal pain, somnolence, thirst, headache, vomiting and psychomotor hyperactivity.   
It is not known whether montelukast is removed by peritoneal dialysis or hemodialysis.
This is the standard technique. In this approach, the needle is passed through the body of the stomach adjacent the celiac artery into the retroperitoneal space in 1 or 2 passes. The injectate (bupivacaine or alcohol) is injected and spreads through the retroperitoneal space, effectively "bathing" all the ganglia.
Seton placement, followed by anti-TNF medication in combination with a immunomodulator after ± 2 weeks. After 8-10 weeks removal of seton and surgical closure (advancement plasty or ligation of the intersphincteric tract (LIFT) procedure). Anti-TNF in combination with a immunomodulator will be stopped after ± 4 months.
Schizophrenia is a disabling and often chronic disorder that may require long-term treatment. This protocol is an extension study of a randomised study comparing the safety of Sertindole versus Risperidone. Patients who were randomised to Sertindole and who completed the previous study have the possibility to receive continued Sertindole treatment in this open one-arm study. Sertindole is generally well tolerated and is approved in the EU, but not yet marketed in France. The follow-up of the patients will be similar to that in the previous study and requires quarterly visits. Patient management reflects routine clinical practice in accordance with the Sertindole label. Any severe safety issue is reported to the company.
An image pre-processing method and an image processing apparatus for fundoscopic are provided. A region of interest (ROI) is obtained from a fundoscopic image, to generate the first image. The ROI is focused on the eyeball in the fundoscopic image. The smoothing process is performed on the first image, to generate the second image. The value difference between neighboring pixels in the second image is increased, to generate the third image. Accordingly, the feature can be enhanced, and it may help the subsequent image recognizing operation.
Venlafaxine hydrochloride extended-release capsules are indicated for the treatment of major depressive disorder. 

The efficacy of venlafaxine hydrochloride extended-release capsules in the treatment of major depressive disorder was established in 8 and 12 week controlled trials of adult outpatients whose diagnoses corresponded most closely to the DSM-III-R or DSM-IV category of major depressive disorder (see Clinical Trials). 

A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed mood or the loss of interest or pleasure in nearly all activities, representing a change from previous functioning, and includes the presence of at least five of the following nine symptoms during the same two-week period: depressed mood, markedly diminished interest or pleasure in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt or suicidal ideation. 

The efficacy of venlafaxine hydrochloride tablets (immediate release) in the treatment of major depressive disorder in adult inpatients meeting diagnostic criteria for major depressive disorder with melancholia was established in a 4 week controlled trial (see Clinical Trials). The safety and efficacy of venlafaxine hydrochloride extended-release capsules in hospitalized depressed patients have not been adequately studied. 

The efficacy of venlafaxine hydrochloride extended-release capsules in maintaining a response in major depressive disorder for up to 26 weeks following 8 weeks of acute treatment was demonstrated in a placebo-controlled trial. The efficacy of venlafaxine hydrochloride tablets (immediate release) in maintaining a response in patients with recurrent major depressive disorder who had responded and continued to be improved during an initial 26 weeks of treatment and were then followed for a period of up to 52 weeks was demonstrated in a second placebo-controlled trial (see Clinical Trials). Nevertheless, the physician who elects to use venlafaxine hydrochloride tablets/venlafaxine hydrochloride extended-release capsules for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION).
PURPOSE: A wash-off clay pack cosmetic composition containing fine particulate soil and polyvinyl alcohol is provided to ensure the formulation stability thereof. CONSTITUTION: A wash-off cosmetic composition contains 0.1-30 wt% of fine particulate soil and 0.01-10 wt% of polyvinyl alcohol. The composition is a cosmetic composition of a pack formulation. The average particle diameter of the fine particulate soil is 10 um or less. The average molecular weight of the polyvinyl alcohol is 170,000-270,000(g/mol). The weight ratio of the fine particulate soil and polyvinyl alcohol is 5-100:1.
PURPOSE:To provide a skin-beautifying cosmetic containing a specific ascorbic acid derivative, having excellent skin-beautifying effect and storage stability and exhibiting improved vitamin C solubility. CONSTITUTION:The objective cosmetic contains an ascorbic acid derivative of formula I [R1 is group of formula II (R3 and R4 are H or CH3; R5 is 1-20C hydrocarbon group, etc.)] or formula III (R2 is same as formula II). The compound of formula I can be produced e.g. by reacting a halocarboxylic acid with tocopherol in the presence of a base (e.g. K2CO3 or NaOH) in a solvent (e.g. DMF or DMSO), reacting the resultant tocopherol carboxylic acid ether with 5,6-O-isopropylidene-L-ascorbic acid produced by the reaction of L-ascorbic acid and acetyl chloride and stirring the reaction product in THF, etc., in the presence of an acid to eliminate the protecting group.
BACKGROUND: Bariatric surgery has significant effects on metabolic parameters and hormone levels. However, the specific impact of laparoscopic sleeve gastrectomy (LSG) on thyroid hormones and other metabolic parameters remains unclear. This study aimed to investigate the short and long-term effects of LSG on thyroid hormone levels, HbA1c, and other metabolic parameters.
METHODS: A total of 619 euthyroid patients without a history of thyroid disease or thyroid hormone replacement therapy were included in the study. Patients with diabetes were excluded from the study. Preoperative, 1-year postoperative, and 5-year postoperative levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), HbA1c, and other metabolic parameters were recorded and analyzed.
RESULTS: LSG resulted in significant weight loss and improvements in metabolic parameters. At 1 year postoperatively, there were significant reductions in BMI, HbA1c, TSH, fT3, and triglyceride levels, while fT4 levels increased. A statistically significant negative correlation was found between preoperative HbA1c level and percentage of total weight loss (%TWL) value at the fifth postoperative year. Additionally, a statistically significant negative correlation was found between the 5-year change in TSH and %TWL.
CONCLUSION: Being the first study to predict long-term total weight loss based on preoperative HbA1c, it is significant. This finding has important implications for personalized patient management and could aid clinicians in identifying individuals who may benefit most from sleeve gastrectomy as a treatment modality. This is valuable in that it emphasizes multidisciplinary work, including the endocrinologist and dietician.
Natural history of Avian influenza A, particularly H5N1 strain which has a high potential of causing a global human pandemic, and real-world treatment practices will be observed in this study. This registry program will not require, recommend, or provide any specific treatment or medications.
PURPOSE: To obtain at a low cost a large quantity of yolk oil retaining physiological activity such as antihyperlipemic action, antidiabetic action, antiallergic action or antisenile action, by subjecting iodine-rich egg's yolk to extraction with ethyl alcohol. CONSTITUTION: This yolk oil is obtained by subjecting the yolk of iodine-rich eggs (e.g. 600-1000μg iodine/egg) obtained by feeding poultry with a feed formulated with sea algae or an iodine compound (e.g. calcium iodide) to extraction with ethyl alcohol. For example, this yolk oil is obtained by the following process: chickens are fed with a feed formulated with 100ppm, on an iodine basis, of calcium iodate, and the eggs delivered at least one week after feeding are gathered, and the yolk therefrom is dried by a combination of microwave and hot-air drying, and 6wt. times of ethyl alcohol is added to the resultant dry yolk followed by agitation for one hour and then centrifugal filtration; the filtrate is filtered through a filter cloth followed by distilling the ethanol off using a distillation unit.
PURPOSE:To perform the medical diagnosis/guidance and to take early treatments to the diseases by forming the medical/health information data in a storage medium as a data base based on the frame concept divided to a lower rank concept from a higher rank concept in terms of types. CONSTITUTION:A terminal equipment consisting of a 16-bit personal computer is provided to perform the input/output of data based on a frame concept. A host computer processes the data received via the terminal equipment. A doctor or a health nurse inputs the group examination data via the terminal equipment, and these input data are processed by a host computer of a data processing organ via alo al self-governing body, etc. Meanwhile the check result of the blood, etc., is directly inputted to the host computer. A data base is formed based on the frame concept. The specific characters of the frame concept includes such fact that the treating method is prepared as a knowledge to the omitted data, etc., and that a network consisting of the frames can be automatically retrieved. Thus it is possible to easily produce the knowledges necessary for guidance, etc., and to easily retrieve the necessary data.
INTRODUCTION: Although rare, injury to the internal carotid artery (ICA) during pituitary surgery may result in serious morbidity such as stroke or death. This case series explores a single centre's incidence and outcomes of ICA injury during endoscopic transsphenoidal pituitary surgery, discusses the current management options, and introduces the 'muscle wonton' (morcellised muscle wrapped in a single sheet of Surgicel®) as being a viable repair option.
METHODS: All patients undergoing pituitary operations from January 2010 to December 2019 at the Queen Elizabeth Hospital, Birmingham, UK were included. Primary outcome was number of internal carotid artery injuries during pituitary surgery. Secondary outcome measures included pre-operative (demographic, risk factors such as previous radiotherapy, number of previous operations, imaging available), operative (intra-operative image guidance, intra-operative doppler ultrasound, which side ICA was damaged, repair technique) and post-operative result (death, cranial nerve VI palsy, or stroke).
RESULTS: 7 out of 893 patients (0.8%) were identified as having an ICA injury. Four of the injuries were left sided. Average age was 54 years old, five were male. In four of the ICA injuries intra-operative navigation imaging was used, and a further two concurrently used ultrasound doppler. Three of the seven cases resulted in permanent morbidity (stroke). There were no other consistent demographic, pre-operative, operative, or post-operative similarities. The two patients with muscle wonton repair suffered no permanent serious complication of ICA injury (i.e. death, abducens nerve palsy, stroke).
DISCUSSION: Our findings resemble the current literature, with left sided ICA injury being more common. Different methods for repairing ICA injury exist, however morcellised muscle patches have shown significant promise in animal models, and the perforated Surgicel® helps create an easy delivery method. The muscle wonton is a viable surgical option for repairing ICA injuries during pituitary surgery.
The invention discloses a preparation method of a recombinant influenza virus vector therapeutic hypertension vaccine. Belongs to the technical field of vaccine biological products. The method is to replace a nucleotide sequence of 280-340 bp of influenza virus NS1 after connecting 9 human angiotensin II genes after 2A enzyme cleavage sites with transferrin in series. Meanwhile, gene segments of the influenza A virus cold adaptation attenuated strain and the influenza vaccine candidate strain are utilized to finish the rescue of the influenza virus in reverse genetics. The main purpose of the invention is to inject hypertension patients intradermally, so that the angiotensin II protein is expressed in the organism, endogenous antigen presentation is completed, and the organism is stimulated to produce corresponding antibodies, thereby antagonizing high-level angiotensin II in the hypertension patients and achieving the purpose of treating hypertension. Meanwhile, the recombinant influenza virus vector carries the surface antigen of the influenza vaccine strain on the surface, so that the purpose of using the influenza vaccine can be achieved at the same time.
A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH. The claimed method provides a new approach for diagnostic and treatment diseases with naturally occurred (or artificially created) low pH extracellular environment such as tumors, infarction, stroke, atherosclerosis, inflammation, infection, or trauma. The method allows to translocate cell impermeable molecules (peptides, toxins, drugs, inhibitors, nucleic acids, peptide nucleic acids, imaging probes) into cells at low pH. The method allows to attach to the cell surface a variety of functional moieties and particles including peptides, polysaccharides, virus, antigens, liposomes and nanoparticles made of any materials.
Obesity is the most common diseases in the United States - an estimated 35% of adults are obese. Among kidney (KT) and liver transplant (LT) recipients, weight gain and obesity is associated with poor graft function. Yet, within a year of transplantation, habituation to a sedentary lifestyle, changes in metabolism, and immunosuppression drugs contribute to an average 4-10 kg weight gain for recipients. Recent innovations in wearable device technology can passively monitor an individual's physical activity. Additionally, incentives and health questions designed using insights from behavioral economics have been shown to motivate device engagement and improvements in health behaviors. A remotely-monitored exercise program could improve behavior change and potentially be durable because it takes advantage of the high motivation for improving health in this population. The objective of this study is to use a randomized, controlled trial to test the efficacy of a home-based exercise program using wearable devices, health engagement questions and financial incentives. Participants in the intervention arm will establish a baseline step count during the first two weeks, followed by a 12-week intervention period and a 4-week follow-up period.
Stripe rust of wheat, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most important diseases of wheat worldwide. Identification of new and elite Pst-resistance loci or genes has the potential to enhance overall resistance to this pathogen. Here, we conducted an integrated genome-wide association study (GWAS) and transcriptomic analysis to screen for loci associated with resistance to stripe rust in 335 accessions from Yunnan, including 311 landraces and 24 cultivars. Based on the environmental phenotype, we identified 113 protein kinases significantly associated with Pst resistance using mixed linear model (MLM) and generalized linear model (GLM) models. Transcriptomic analysis revealed that 52 of 113 protein kinases identified by GWAS were up and down regulated in response to Pst infection. Among these genes, a total of 15 receptor kinase genes were identified associated with Pst resistance. 11 candidate genes were newly discovered in Yunnan wheat germplasm. Our results revealed that resistance alleles to stripe rust were accumulated in Yunnan wheat germplasm, implying direct or indirect selection for improving stripe rust resistance in elite wheat breeding programs.
PURPOSE: This study aimed to developed a novel and practical method to quantify the involvement of lesion in osteonecrosis of the femoral head (ONFH). We hypothesized that the new metric large lesion ratio (LLR) had promising prognostic value.
METHODS: A total of 131 hips with non-traumatic ONFH were included in this retrospective study. Patient aged 18-60 with MRI-confirmed diagnosis, and a minimum of 2-year follow-up or radiographic collapse progression during follow-up were included. Patients with prior hip surgery, incomplete data or advanced ONFH at baseline (femoral head collapse > 2 mm or osteoarthritis) were excluded. Involvement of necrotic lesion was evaluated by calculating LLR. The differences of LLR between collapse progression and non-progression groups were investigated, and the differences among different scanning parameters groups were also examined. Prognostic value of LLR was examined by multivariate regression analysis. Receiver operating characteristic curves (ROC) were constructed and areas under the curve (AUC) were compared.
RESULTS: The median of LLR was 66.67% in the collapse progression group, which was significantly higher compared with 25.00% in the non-progression group (P < 0.001). Subgroups analysis showed that LLR were significantly higher in the collapse progression group of Japanese Investigation Committee type C1 (P < 0.001)and C2 (P = 0.002). Multivariate regression showed that LLR were independently correlated with collapse progression (OR, 1.46 [95% CI, 1.24-1.78]; P < 0.001). ROC analysis showed that the AUC for LLR was 0.84, outperforming the 0.74 AUC OF the JIC classification.
CONCLUSION: LLR could served as a efficient tool to assess the risk of collapse progression and guide the selection of treatment strategy.
The invention provides a traditional Chinese medicine composition for treating insomnia caused by fire excess from yin deficiency, and relates to the field of traditional Chinese medicines. The composition comprises the following raw materials in parts by weight: 13 to 17 parts of rhizoma polygonati, 10 to 14 parts of dendrobium, 13 to 17 parts of mulberry, 28 to 32 parts of Guangxi yam, 13 to 17 parts of dried longan pulp, 28 to 32 parts of concha ostreae and 18 to 22 parts of tortoise shell. The composition can be of a combined preparation, granules or capsules. The composition has functions of nourishing yin for lowering fire and nourishing the heart for tranquilizing mind, and is used for treating insomnia caused by fire excess from yin deficiency. The composition is definite in treatment effect, stable in dosage form, controllable in quality and free of toxic and side effects. Thus, the composition is a modern preparation which can be easily popularized.
This pilot study is a prospective study coordinated by the Department of Translational Medicine, Section of Pediatrics, University of Naples "Federico II", whereas infants were recruited by 8 general pediatricians belonging to the Pediatrics Investigator Committee of Campania Region, Italy. Inclusion criteria were: full term infants (\>_37 weeks gestation at birth; 5-min Apgar score \>_7; Birth weight \>_2500 g), aged \<12 months, diagnosed with IC according to Rome IV criteria \[1\], breast- and formulafed infants. The parents of the infants participating in the study were supplied with the mixture of Tyndallized B. Coagulans and Simethicone. The Institutional Review Board of Campania 3 approved the research protocol. All parents gave written informed consent. Enrolled infants were treated for 28 days with a mixture of Tyndallized B. Coagulans and Simethicone: 20 drops, four times a day. At enrolment, clinical and dietary history, obstetrical data and anthropometry were recorded. The subjects were classified as having IC based on their parents' responses to the validated questionnaires regarding IC according to Rome IV criteria. The parents were also asked to fill in the following questionnaires: 1) Baby's Day Diary on daily crying and infant sleep duration \[21\]; 2) a scale (visual analogue scale, VAS, 0e10) for parents' quality of life, a questionnaire on infant's quality of life; 3) a form for stool frequency and consistency; 4) a scale for parental perception of colic severity (VAS 0e10) and 5) a scale for parental perception of sleep quality (VAS 0 e10). Infants were evaluated by a physician for follow-up visits at week 4. During the visits, physical examination was performed and information regarding drugs administration, number and site of infections and eventual adverse medical events were recorded. Moreover, parents had to fill: 3) the questionnaire on infant's quality of life; 4) a review of stool frequency and consistency; 5) the parental perception of colic severity (VAS 0e10) and 6) the parental perception of sleep quality (VAS 0e10). All the authors had access to the study data. Compliance was assessed by evaluating the diary provided by the parents.

Outcomes The primary endpoint was the infant crying duration at 28 days. Treatment success was defined as at least 50% reduction in crying time from baseline to day 28 postintervention. Secondary endpoints included: infant sleep duration at 28 days post-intervention, mean scores on a standardized measure of parents' and infants' quality of life, changes in stool consistency, number of episodes of infant colic per day, parental perception of colic severity (VAS 0-10), parental perception of quality of life (VAS0-10).