anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nervous system adverse reactions of any grade were reported for 223 (76%) adult patients across the Phase I and Phase II trials, and Grade 3 or higher (severe, life-threatening, or fatal) adverse reactions were reported for 55 (19%) patients following initiation of nelarabine therapy [see Adverse Reactions (6.1)]. Based on patients with complete data, the median time to onset of first event is 5 days from start of first infusion (range: 1 to 166), and the median duration is 6 days (range: 1 to 393 days).

Nervous system adverse reactions of any grade were reported for 69 (42%) pediatric patients across the Phase I and Phase II trials, and Grade 3 or higher (severe, life-threatening, or fatal) adverse reactions were reported for 25 (15%) patients following initiation of nelarabine therapy [see Adverse Reactions (6.1)]. Based on patients with complete data, the median time to onset of first event is 8 days from start of first infusion (range: 1 to 269), and the median duration is 2 days (range: 1 to 82 days).

Common signs and symptoms of nelarabine injection-related neurotoxicity include somnolence, headache, paresthesia and dysesthesia, dizziness, neuropathy (sensory and motor), cerebellar disturbances and tremor. Severe neurologic toxicity can manifest as coma, status epilepticus, craniospinal demyelination, or ascending neuropathy similar in presentation to Guillain-Barré syndrome.

Full recovery from these adverse reactions has not always occurred with cessation of therapy with nelarabine injection. Patients treated previously or concurrently with intrathecal chemotherapy or previously with craniospinal irradiation may be at increased risk for neurologic adverse events.

Monitor patients frequently for signs and symptoms of neurologic toxicity during and for at least 24 hours after completion of treatment with nelarabine injection. Discontinue nelarabine injection for neurologic adverse reactions of NCI CTCAE Grade 2 or greater and provide supportive care [see Dosage and Administration (2.2), Adverse Reactions (6.1)].
Bariatric surgery leads to improvement or resolution of a variety of health conditions. It is also well established that physical activity, with or without weight loss, improves many health-related problems and can have a positive impact on mood. Therefore, physical activity may amplify the health and psychological benefits often experienced from bariatric surgery. Prior to surgery many patients are relatively inactive due to physical and social barriers associated with their weight. In addition, many patients find it difficult to adopt an active lifestyle after surgery, despite an increased capacity to exercise. However, weight loss is associated with physical activity after bariatric surgery. Nonetheless, little is known about the most effective means to promote activity among this group of individuals. This study will examine changes in physical activity and fitness after bariatric surgery and examine whether the addition of pedometer use and exercise counseling may lead to greater improvements.
FIELD: pharmaceutical industry. SUBSTANCE: food supplement comprises as active substances dill seeds infusion, nettle leaves infusion, marjoram herb infusion, carrot juice, ginger, potassium iodide, ascorbic acid and accessory substance: sugar, starch, oat, calcium stearate being each active component is taken in the dose 0.1-99 wt.-%. The invention can be used as a medicinal agent in breast milk deficiency in nursing women, in aggravated obstetric anamnesis and hypolactation, in hypertrophy and anorexia in nursing baby and infantile age. Invention ensures to obtain product with antioxidant properties. EFFECT: valuable properties of supplement. 1 ex
Thienopyridines, including clopidogrel bisulfate, increase the risk of bleeding. If a patient is to undergo surgery and an antiplatelet effect is not desired, discontinue clopidogrel bisulfate five days prior to surgery. In patients who stopped therapy more than five days prior to CABG the rates of major bleeding were similar (event rate 4.4% clopidogrel bisulfate + aspirin; 5.3% placebo + aspirin). In patients who remained on therapy within five days of CABG, the major bleeding rate was 9.6% for clopidogrel bisulfate + aspirin, and 6.3% for placebo + aspirin. 

Thienopyridines inhibit platelet aggregation for the lifetime of the platelet (7 to 10 days), so withholding a dose will not be useful in managing a bleeding event or the risk of bleeding associated with an invasive procedure. Because the half-life of clopidogrel's active metabolite is short, it may be possible to restore hemostasis by administering exogenous platelets; however, platelet transfusions within 4 hours of the loading dose or 2 hours of the maintenance dose may be less effective.
This arm will comprise patients with heart failure who are predicted to receive high benefit (reduction in mortality risk) by addressing open care gaps. Following randomization, they will continue to receive clinical standard-of-care: regular follow-ups with Community Medicine (every 3 months) and Cardiology (every six months). Importantly, these individuals are eligible for referral to MTM at the discretion of their physicians.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely oncology, and can be used for treating malignant pleurisy. A method involves successive intrapleural introduction of ingredients of a binary catalyst system: the oxidation substratum - ascorbic acid and the oxidation catalyst oxycobalamin. A range of the introduced doses makes 100-200 mg/kg for oxycobalamin, 125-250 mg/kg for ascorbic acid. ^ EFFECT: use of the invention allows providing higher effectiveness in malignant pleurisy and reducing its toxicity. ^ 1 tbl
The American Academy of Pediatrics urges pediatricians to counsel parents on the dangers of childhood access to firearms and restrict access through safe storage practices. However, evidence suggests that most pediatricians do not provide firearm-related counseling in real-world clinical practice. This is notable as firearm-related injury is now the leading cause of death in children aged 1-19 years in the United States. Virtual reality (VR) is a type of simulation-based medical education that allows users to interact with virtual environments and characters in a seemingly realistic way. Investigators developed Resident Education And Counseling on Household (REACH) Firearm Safety, a VR curriculum to allow pediatricians to practice screening and counseling on firearm safety. The objective of this proposal is to assess the efficacy of REACH Firearm Safety, along with key implementation metrics, to justify and inform scale and distribution of the training approach. To achieve the objective, Investigators will: (1) Conduct a multi-site two-arm randomized controlled pilot study assessing the efficacy of REACH Firearm Safety and (2) Measure acceptability, appropriateness, fidelity, feasibility, and cost of implementation of REACH Firearm Safety. The proposed research is significant and innovative because it is the first rigorous effort to evaluate the efficacy of VR as a training platform to teach communication skills related to firearm safety counseling.
PURPOSE:To improve odor by contacting an alkali substance with a feedstock cedarwood oil, removing any reaction products to obtain a residue, reacting the residue with a specific alcohol and removing any reaction products. CONSTITUTION:0.001-0.1 pt.wt. alkali substance is contacted at 0-100 deg.C for 0.1-5hr with 1 pt.wt. feedstock cedarwood oil selected from among a crude cedarwood oil (a) obtained by steam distillation of wood containing cedarwood oil, a purified cedarwood oil (b) obtained by distillation or fractionation of oil (a), a treated cedarwood oil (c) obtained by distilling off hydrocarbon components from oil (a) and a crystallization mother liquor (d) obtained by removing cedrol from oil (c) by crystallization. Any reaction products are removed to obtain a residue. The obtained residue is contacted with 0.1-10 pts.wt. primary or secondary alcohol in the presence of 0.001-1.0 pt.wt. di-tert.-butyl peroxide at 100-200 deg.C for 0.1-10hr. Any reaction products are removed by fractionation.
We were performed spinal anesthesia sitting position by midline. After confirming the free flow of cerebrospinal fluid, bupivacaine was administered without aspiration.ECG recordings were performed at preoperative, 5, 15, and 30 minutes after initial anesthesia and 30 minutes post-operatively.
Dry eye syndrome (DES) is a prevalent and multifactorial disease that leads to a self-perpetuating cycle of inflammation and damage to the ocular surface. This results in symptoms such as redness, burning, and blurred vision, which can negatively affect a patient's quality of life. While treatments are available to manage DES, they only temporarily relieve symptoms. Furthermore, long-term use of certain medications can cause harm to the ocular surface. Therefore, there is a need for safer and effective treatments for DES. This review highlights the latest advancements in DES therapy, providing valuable insights into ongoing efforts to improve patient outcomes.
Cartilage tissue and implants comprising cartilage tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space ( 1 ) and are left in this cell space for producing an extracellular cartilage matrix. The cells are brought into the cell space to have a cell density of ca. 5×10 7  to 10 9  cells per cm 3  of cell space. The cell space ( 1 ) is at least partly separated from a culture medium space ( 2 ) surrounding the cell space by a semi-permeable wall ( 3 ) or by an open-pore wall acting as convection barrier. The open-pore wall can be designed as a plate ( 7 ) made of a bone substitute material and constituting the bottom of the cell space ( 1 ). The cells settle on such a plate ( 7 ) and the cartilage tissue growing in the cell space ( 1 ) grows into pores or surface roughness of the plate, whereby an implant forms which consists of a bone substitute plate ( 7 ) and a cartilage layer covering the plate and whereby the two implant parts are connected to each other in positively engaged manner by being grown together.
Formulation for administration by injection, comprises a photosensitizing substance in photodynamic therapy or in diagnosis therapy, having palladium complex (II), or one of its alkali or alkaline earth metal salts, in combination with a surfactant and mannitol. Formulation for administration by injection, comprises a photosensitizing substance in photodynamic therapy or in diagnosis therapy, having palladium complex of formula (II), or one of its alkali or alkaline earth metal salts, in combination with a surfactant and mannitol. R 2H, OH or -COOR 4; R 4H, 1-12C alkyl or 3-12C cycloalkyl; and R 3H, OH, alkyl or 1-12C alkoxy. An independent claim is included for a preparation of the injectable solution for photodynamic therapy or diagnosis therapy, comprising the photosensitizing substance, comprising dissolving the photosensitizing agent in a mixture of the solvent and surfactant by stirring, until to obtain a homogeneous solution, adjusting the pH to a value of greater than 7 by adding a mannitol added buffer. [Image] ACTIVITY : Cytostatic; Dermatological; Keratolytic; Ophthalmological. MECHANISM OF ACTION : None given.
An anti-aging skin-tendering skin-nourishing beauty-maintaining formula is scientifically reasonable composed of ginger processed pinellia, bletilla striata, radix angelicae dahuricae, rhizoma typhonii, smooth apricot kernel and radix astragali. Firstly, a medicine-soup fumet is firstly prepared through processing in a high-pressure high-temperature environment. Secondly, by adding a gel matrix homogenate and other additives, a series of products such as anti-ageing skin-care beauty-maintaining ointment, spot-removing anti-acne tendering whitening skin-nourishing cream, anti-ageing skin-moistening emulsion, wrinkle-removing skin-nourishing masks and the like are prepared. The formula employs natural pure Chinese herbal medicines as raw materials, is prepared by performing high-temperature high-pressure refining in an aseptic environment, and is substantial in tendering whitening skin-beautifying effect. Because the collateral-vessel freeing, transportation and transformation functions of the Chinese herbal medicines are reasonable utilized, the effective nutrients in the solution can be absorbed by skin cells in a short time, the restoration function is enhanced, the propagation speed of newborn skin cells is accelerated, and thus the effects of resisting ageing, removing spots, removing acnes, tendering, whitening and recovering skin elasticity are realized. The formula is strong in stability and free of any side effects. A large number of practical examples show that the crowds, who realize self psychological effect after using the beauty-maintaining product, still keep tendered young skin when do not use the skin-care product again.
The COVID-19 pandemic has affected the lifestyles of people of all ages, conditions and occupations. Social distance, remote working, changes in diet and a lack of physical activity have directly and indirectly affected many aspects of mental and physical health, particularly in patients with many comorbidities and non-communicable diseases (NCDs). In our paper, we analyzed COVID-19 hospitalized and non-hospitalized cases according to comorbidities to assess the average monthly percentage change (AMPC) and monthly percentage change (MPC) using open access data from the Chilean Ministry of Science, Technology, Knowledge and Innovation. As expected, the infection mainly affected patients with comorbidities, including cardiovascular risk factors. The hospitalized cases with obesity and chronic lung disease increased throughout the period of June 2020-August 2021 (AMPC = ↑20.8 and ↑19.4%, respectively, p < 0.05), as did all the non-hospitalized cases with comorbidities throughout the period (AMPC = ↑15.6 to ↑30.3 [p < 0.05]). The increases in hospitalizations and non-hospitalizations with comorbidities may be associated with physical inactivity. A healthy lifestyle with regular physical activity may have had a protective effect on the COVID-19 severity and related events in the post-pandemic period, especially for the NCD population.
PURPOSE: Visual snow syndrome comprises a whole-field static-like visual disturbance, with increased awareness of entopic phenomena, an inability to suppress the 'just seen' and photophobia. Visual snow syndrome is often associated with other problems such as headache, tinnitus, and anxiety. The earliest reported case of a patient experiencing symptoms consistent with visual snow syndrome dates only to 1995. This paper seeks to find patterns of experience in the medical literature of the past that are reminiscent of visual snow syndrome, to challenge the view that it is in any sense a novel disorder. Descriptions of subjective visual sensations such as experienced by patients suffering from visual snow syndrome were sought in treatises, textbooks and other literature generated by leading figures in 19th-century ophthalmology, physiology and physics.
CONCLUSION: While retrospective diagnosis of modern illness categories in historical medical literature is an enterprise fraught with pitfalls, it is nonetheless possible to see patterns of experience in the 19th-century medical literature that are strongly reminiscent of visual snow syndrome.
Patients should be informed that Butalbital, Aspirin, and Caffeine Capsules, USP contains aspirin and should not be taken by patients with an aspirin allergy.

Butalbital, Aspirin, and Caffeine Capsules, USP may impair the mental and/or physical abilities required for performance of potentially hazardous tasks such as driving a car or operating machinery. Such tasks should be avoided while taking Butalbital, Aspirin, and Caffeine Capsules, USP.

Alcohol and other CNS depressants may produce an additive CNS depression when taken with Butalbital, Aspirin, and Caffeine Capsules, USP and should be avoided.

Butalbital may be habit-forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no more frequently than prescribed.
FIELD: biotechnology, medicine, biochemistry, immunology. SUBSTANCE: invention relates to vaccine that represents particles 25-30 nm by diameter containing polynucleotide complex (recombinant plasmid DNA comprising genes of infectious agent or double-stranded RNA-stimulator of nonspecific resistance of organism) in center and fused protein on surface comprising epitopes (polypeptides) of infectious agent and enzyme (for example, glutathione S- transferase or β- galactosidae). Linkage between polynucleotide complex and fused proteins is carried out conjugate : spermidine (for linkage of conjugate with polynucleotide complex) polyglucine- substrate for enzyme (for example, glutathione or galactopyranoside) for affinity sorption of fused proteins for construction. Vaccine provides the broader titer of antibodies and more prolonged immune response in immunization. EFFECT: enhanced effectiveness and valuable medicinal properties of vaccine. 6 dwg, 4 ex
For patients in this group, intervention (i.e. recommendation) will be made to physicians by the clinical pharmacist. Within the intervention group, patient characteristics such as the length of hospital stay, reason for hospitalization, underlying conditions, and the appropriateness of prescribed medications were evaluated for the patients who received antithrombotic treatment and met the inclusion criteria. Through medication reviews, evaluations were made to identify drug-related problems and provide solutions to these problems. The clinical pharmacist provided recommendations to the physicians regarding significant clinically important problems. Additionally, follow-up was performed to determine whether the patients had a re-admission within 3 months.
Coumarone derivatives of formula <FORM:1063158/C2/1> wherein R1 is hydrogen or a methyl or phenyl substituent, R2, R3, R4 and R5 are hydroge atoms or C1- 12 alkyl groups or R2 and R3 or R3 and R4 together form a C3- 4 alkylene group and in which the benzene ring of the benzofuran may optionally be substituted by one or more C1- 12 alkyl groups and/or sulphonic acid groups and salts of the sulphonic acids, many of which derivatives are novel, may be obtained in the case of those compounds which do not contain sulphonic acid substituents by (1) reaction of a benzofuran-2-carboxylic acid chloride or bromide with benzene or an alkylbenzene or by (2) reaction of the sodium salts of salicyclic aldehydes or o-hydroxy phenyl ketones with o -halogeno-acetophenones which may be alkylated in the aromatic ring.  The corresponding sulphonic acids may be obtained by sulphonation of the benzoyl benzofurans with sulphuric acid and desired salts obtained by reaction of the sulphonic acids with a base.  Compounds of the formula above in which R1 is -CH3, R5 and R3 are hydrogens, R4 is H, -CH3 or -C2H5, R2 is H or -CH3 and the benzofuran ring is substituted or not in the -4-position by a C1- 12 alkyl group, and also compounds of formula above, wherein the benzene ring of the benzofuran is substituted by an -SO3H group with or without also being substituted by C1- 12 alkyl group(s) and their salts are claimed per se. Also claimed are 2-benzoyl-3-methyl-, (2,4-dimethylbenzoyl)-, 2 - (2,4 - dimethylbenzoyl)-3 - methyl-, 2 - benzoyl - 3,5 - dimethyl-, 2-benzoyl - 3 - methyl - 5 - nonyl-, and 2 - benzoyl-3 - phenyl - benzofurans.ALSO:Cosmetic ultraviolet absorption agents comprise an admixture of an inert, physiologically-acceptable carrier suitable for topical application and a compound of the formula: <FORM:1063158/A5-A6/1> wherein R1 is a hydrogen, methyl or phenyl radical, R2, R3, R4 and R5 are hydrogen or a C1-12 alkyl group, or R2 and R3 or R3 and R4 together form a C3-4 alkylene group and wherein the benzene ring of the benzofuran may be substituted by one or more C1-12 alkyl and/or sulphonic acid groups. Suitable additives and solvents are hydrocarbons, vegetable or animal oils and fats, fatty acids and fatty acid esters, mono- and poly-hydric alcohols of which many are specified.  The agents may take the form of water-in-oil or oil-in-water emulsions and thickeners may be added, as well as perfumes, preservatives and dyestuffs.  The agents may also contain one or more other ultraviolet absorbers such as the sodium salts of 2-phenylbenzimidazol-5-sulphonic acid and 3,4-dimethylphenylglyoxylic acid, 4-phenyl-benzophenone, and isooctyl-4-phenylbenzophenone-2\sv-carboxylate.
PURPOSE:To obtain the titled inhibitor, consisting of respective ampholytic surfactants of carboxylic acid salt, sulfuric acid ester salt, sulfonic acid ester salt and phosphoric acid ester salt types and useful for inhibiting and preventing viral infection in public bathhouses, such as soap land or public bath. CONSTITUTION:The titled inhibitor consisting of a nitrogen atom-containing ampholytic surfactant selected from the group of carboxylic acid salt type ampholytic surfactants [especially (alkylaminoethyl)glycine salts, dialkyldiethylenetriaminoacetic acids, etc.], sulfuric acid ester salt type ampholytic surfactants (e.g. N-dodecyl-N,N-dimethyl-aminoethyl sulfate), sulfonic acid ester salt type ampholytic surfactant (e.g. alkyldimethyl-gamma- sulfopropylammonium) and phosphoric acid ester salt type ampholytic surfactants. This inhibitor is capable of remarkably reducing a chance of infection with viral diseases, such as AIDS, having high variability.
PURPOSE: To provide the high-activity bacterin which is formed from the cells obtd. by growing bovine fractions rich in cholesterol as a nutritive medium and is useful for the shigella infection of swine. CONSTITUTION: This bacterin is formed from the cells obtd. by growing Treponema hyodysenteriae which is an anaerobic spirochaeta in the nutritive medium contg. the bovine fractions obtd. by (i) bringing an adsorbent of silica into contact with the bovine plasma or serum contg. the liquid cholesterol, adsorbing and separating the cholesterol; (ii) freezing and thawing the adsorbed cholesterol, eluting the cholesterol at pH 9.0 to 11.5, thickening the eluted cholesterol by ultrafiltration; (iii) dialyzing the concd. cholesterol soln. with Na carbonate in water, (iv) thickening the dialyzed cholesterol soln. 5.0 to 3000 mg/dl, adjusting its pH to 7.0 to 11.0 and further, heating the soln. for 30 minutes to 24 hours at 50 to 100 deg.C and (v) obtaining the bovine fractions rich in the refined cholesterol.
PURPOSE:To simply measure isolated type thyroxin in blood, by performing an enzyme immunoassay using a bond of thyroxin and beta-D-galactosidase as enzyme as labelled antigen. CONSTITUTION:A T4-beta-D-galactosidase is obtained by maleimide method from thyroxin (T4) and beta-D-galactosidase as large molecular weight protein. The bond thus obtained is inactive to thyroxin-bonded globuline (TBG) and albumin but makes a bond reaction with T4. The T4-protein bond is used as labelled antigen to measure thyroxin T4 in blood by an enzyme immunoassay. Here, the bond can be used as enzyme labelled antigen as T4 is coupled to large molecular weight enzyme. Thus, the use of the labelled antigen enables sensitive measurement of isolated type thyroxin without being affected by coexisting components in blood, TBG and the like and this method is highly effective for the decision on the function of a thyroid gland.