anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Melanoma accounts for approximately 5% of all skin cancers in the United States, but it accounts for about 75% of all skin cancer deaths. In 2004, the expected prevalence of melanoma is 627,252, with about 119,178 of these cases being Stage III or IV (metastatic melanoma). First line treatments for metastatic melanoma, usually IL-2, dacarbazine and/or temozolomide, are associated with significant toxicities. MDX-010 (anti-CTLA4) antibodies are designed to keep the immune system running by blocking CTLA-4 from down-regulating T cell activation. MDX-1379 is made up of two peptides that are pieces of a bigger melanoma protein (gp100). These peptides bind to HLA-A2 which is then recognized by T cells.
This invention relates to methods for producing immune cells expressing a therapeutic antigen receptor. An immune cell is provided that comprises a heterologous expression cassette. The heterologous expression cassette comprises (a) a coding sequence for a production TCR, (b) a constitutive promoter operably linked to the coding sequence, (c) a 5' targeting site, and optionally (d) a 3' targeting site. An expression construct is then introduced into the immune cell at the site of the heterologous expression cassette. The expression construct comprises a coding sequence for a therapeutic antigen receptor and the therapeutic antigen receptor is then expressed in the immune cell. Methods, reagents for use in the methods and immune cells produced by the methods are provided.
In the PRE intervention group (before the traditional teaching) students will practice in pairs, with the same low fidelity simulator, the blood collection technique without a teacher in the classroom. In the SimCapture for Skills interface, the procedure of how to perform the technique (sequence of actions) will be developed in checklist format for the student to check step by step. They will be provided with the same material and classroom time as in traditional teaching (2h).
Gut microbial dysbiosis, especially bacteriome, has been implicated in Alzheimer's disease (AD). However, nonbacterial members of the gut microbiome in AD, such as the mycobiome, archaeome, and virome, are unexplored. Here, we perform higher-resolution shotgun metagenomic sequencing on fecal samples collected longitudinally from a mouse model of AD to investigate longitudinal and multi-kingdom gut microbiome profiling. Shotgun metagenomic sequencing of fecal samples from AD mice and healthy mice returns 41,222 bacterial, 414 fungal, 1836 archaeal, and 1916 viral species across all time points. The ecological network pattern of the gut microbiome in AD mice is characterized by more complex bacterial-bacterial interactions and fungal-fungal interactions, as well as simpler archaeal-archaeal interactions and viral-viral interactions. The development of AD is accompanied by multi-kingdom shifts in the gut microbiome composition, as evidenced by the identification of 1177 differential bacterial, 84 differential fungal, 59 differential archaeal, and 10 differential viral species between healthy and AD mice across all time points. In addition, the functional potential of the gut microbiome is partially altered in the development of AD. Collectively, our findings uncover longitudinal and multi-kingdom gut microbiome alterations in AD and provide a motivation for considering microbiome-based therapeutics during the prevention and treatment of AD.
The invention relates to a preparation method of a modified drug-loading PAN nanometer fiber mat. A drug-loading nanometer fiber mat is successfully prepared by taking PAN as a main spinning material and mixing acyclovir, and a modified ion-exchange-type nanometer fiber is successfully prepared through a chemical method. The drug-loading nanometer fiber mat is prepared by dissolving dried polyacrylonitrile (PAN) and acyclovir in DMAc to prepare a spinning solution through electrostatic spinning. The PAN nanometer fiber mat obtained from electrostatic spinning is treated with NaOH, is soaked in an HCl solution, is washed with double-distilled water till the obtained mat is neutral, and is dried. The obtained fiber mat is soaked in a drug solution to obtain the modified drug-loading ion-exchange-type nanometer fiber mat. The drug-loading nanometer fiber mat has excellent drug release properties. The ion-exchange-type nanometer fiber mat has excellent reutilization and high practical value.
Bleomycin sulfate is a white or yellowish white or cream colored amorphous hygroscopic powder. It is very soluble in water slightly soluble in dehydrated alcohol, and practically insoluble in acetone and ether.

It is a purified mixture of glycopeptides produced by a fermentation process employing the actinomycetes Streptoverticillium species. The bleomycin mixture contains predominantly the A2, and B2, peptides. When reconstituted in water for injection, the pH of the solution is approximately 5. Each vial contains 55 to 70% of bleomycin A2, and 25 to 32% of bleomycin B2.

Bleomycin injection contains the excipients: hydrochloric acid and sodium hydroxide, both for pH adjustment.
PURPOSE:To efficiently produce a lysoglycolipid useful, e.g. as a raw material for a medicine, a reagent of clinical analysis and a biochemical material by allowing to act a glycosphingolipidceramide deacylase-producing microorganism (extract) which belongs to Streptomyces on a glycosphingolipid. CONSTITUTION:A glycosphingolipidceramide deacylase-producing microorganism [e.g. Streptomyces sp. H-37 (FERM-P-13822)] which belongs to Streptomyces or its extract is reacted with a phosphate buffer solution containing 0.1 to 10wt.% glycosphingolipid in the presence of a bile-based surfactant (e.g. glycodeoxycholic acid) or a nonionic surfactant at 30 to 40 deg.C in the vicinity of neutral pH. Insoluble components such as cell bodies existing in the reaction solution are subsequently separated and removed according to the centrifugal separation method, the filtration method, etc., and the objective lysoglycolipid produced by the reaction is then collected.
A Caucasian male in his 60s presented with acute onset of dizziness, dysarthria, and gait ataxia. Upon extensive workup, positive findings were cerebrospinal fluid (CSF) showing lymphocytic pleocytosis with oligoclonal bands, positive celiac disease autoantibodies in blood, a duodenal biopsy indicating lymphocytic infiltration, and positive anti-mGluR1 antibody titers in CSF. The patient was started on a strict gluten-free diet and intravenous immunoglobulin therapy for 5 days and showed mild consecutive improvements each day of treatment. He was discharged after 22 days, and was encouraged to continue gluten adherence, physical and speech therapy, and follow up with neuroimmunology. This report demonstrates that autoimmune encephalitis due to anti-mGluR1antibodies and gluten ataxia are both immune-mediated disorders that should be considered in acute cerebellar ataxia cases. By broadening the differential diagnosis and a comprehensive CSF analysis, identification of gluten ataxia and autoimmune encephalitis were beneficial in the management of this particular patient.
Subjects will receive a dietary supplement containing resistant starch and be instructed to take 2 tablespoons (\~20 grams) twice daily for 14 days. Initially subjects will take 2 tablespoons once daily for the first three days prior to increasing to 2 tablespoons twice daily.
Surgical margins following rectal cancer resection impact oncologic outcomes. We examined the relationship between margin status and race, ethnicity, region of care, and facility type. Patients undergoing resection of a stage II-III locally advanced rectal cancer (LARC) between 2004 and 2018 were identified through the National Cancer Database. Inverse probability of treatment weighting (IPTW) was performed, with margin positivity rate as the outcome of interest, and race/ethnicity and region of care as the predictors of interest. In total, 58,389 patients were included. After IPTW adjustment, non-Hispanic Black (NHB) patients were 12% (p = 0.029) more likely to have margin positivity than non-Hispanic White (NHW) patients. Patients in the northeast were 9% less likely to have margin positivity compared to those in the south. In the west, NHB patients were more likely to have positive margins than NHW patients. Care in academic/research centers was associated with lower likelihood of positive margins compared to community centers. Within academic/research centers, NHB patients were more likely to have positive margins than non-Hispanic Other patients. Our results suggest that disparity in surgical management of LARC in NHB patients exists across regions of the country and facility types. Further research aimed at identifying drivers of this disparity is warranted.
PROBLEM TO BE SOLVED: To prepare compound powder having smoothness and excellent spreadability, excellent in adhesion to skin and useful for cosmetics such as powder foundation, powdered face powder, eye shadow or the like by coating the surface of powder with boron nitride. SOLUTION: This compound powder is produced by coating the surface of (A) powder (e.g. mica or the like) pref. having 5-30 μm average particle diameter with (B) boron nitride from pref. a precursor polymer for boron nitride (e.g. a polymer from borazine, or the like) pref. in a content of 5-50 wt.% based on the weight of the component A. The compound powder is prepared by dissolving the above polymer in a polar, organic solvent (e.g. tetrahydrofuran or the like) and by stirring the component A as base powder into the solution, followed by spray-drying the mixture and by baking it pref. at 1,100-1,300 deg.C.
Methods are provided herein for maintaining, enhancing, and improving the health of pregnant women, infants, and children by administering compositions that comprise an isolated lactoferrin. The compositions may further comprise a nutritional mixture formulated to supplement the diet of the subject to be treated, and the compositions lack an inorganic source of iron. The nutrient mixture compositions may comprise at least vitamins B6 and folic acid and/or vitamin B12. The methods provided herein include methods for preventing (reducing the likelihood of occurrence of) a pregnancy-associated complication, such as miscarriage, placental abruption, premature birth, or preterm labor. Also provided are methods for preventing (reducing the likelihood of occurrence) or treating a postpartum-associated condition. Methods are also provided for preventing or reducing the likelihood of occurrence of a thrombotic event in a subject by administering a composition comprising a lactoferrin or administering a preparation that comprises lactoferrin and a nutrient mixture formulated to supplement the diet of the subject and which lacks an inorganic source of iron.
The method for treating psoriasis comprises the complex therapy including Glutoxim. Ten injections of Glutoxim are prescribed. The therapeutic complex is individualized depending on the stage of the disease. In the case of the stationary stage of the psoriasis, the following treatment schedule is appropriate: 1.0 ml of vitamin B6 intramuscularly every other day for 20 days; B12 at a dose of 500 ?g intramuscularly every other day for 20 days; Glutoxim in a volume of 1.0 ml once a day for 10 days. In the case of the progressive disease the seasonal drugs are prescribes: Hypothiaside - 50 mg once a day for 10 days; Asparcam - 1 tablet thrice a day for 10 days; calcium gluconate intramuscularly in a volume of 5.0 ml for 10 days. In seven days after the beginning of the treatment, the following schedule is used: Glutoxim in a volume of 1.0 ml once a day for 10 days; 1.0 ml of vitamin B6 intramuscularly every other day for 20 days; B12 at a dose of 500 ?g intramuscularly every other day for 20 days. 2% salicylate ointment is prescribed topically. In the autumn and in the spring, the ultraviolet irradiation is also used.
PURPOSE:To provide a hair grower capable of removing blood capillary leakage through providing the blood capillaries under the scalp with flexibility or elasticity leading to hair growth promotion. CONSTITUTION:The objective hair grower containing, as the essential ingredients, (A) 0.01-5 (pref. 0.05-2) wt.% of vitamin P (e.g. a mixture of hesperidin, erichdiol and rutin; as commercially available ingredient, hesperidin, vitamin P, or rutin, pref. rutin) and (B) 0.01-10 (pref. 0.03-5) wt.% of vitamin C. This hair grower having hair growth-promotive effect is ensured to normally functioning blood capillaries taking advantage of protective action with said vitamin on the blood capillaries.
The electron transport chain (ETC) of mitochondria, bacteria, and archaea couples electron flow to proton pumping and is adapted to diverse oxygen environments. Remarkably, in mice, neurological disease due to ETC complex I dysfunction is rescued by hypoxia through unknown mechanisms. Here, we show that hypoxia rescue and hyperoxia sensitivity of complex I deficiency are evolutionarily conserved to C. elegans and are specific to mutants that compromise the electron-conducting matrix arm. We show that hypoxia rescue does not involve the hypoxia-inducible factor pathway or attenuation of reactive oxygen species. To discover the mechanism, we use C. elegans genetic screens to identify suppressor mutations in the complex I accessory subunit NDUFA6/nuo-3 that phenocopy hypoxia rescue. We show that NDUFA6/nuo-3(G60D) or hypoxia directly restores complex I forward activity, with downstream rescue of ETC flux and, in some cases, complex I levels. Additional screens identify residues within the ubiquinone binding pocket as being required for the rescue by NDUFA6/nuo-3(G60D) or hypoxia. This reveals oxygen-sensitive coupling between an accessory subunit and the quinone binding pocket of complex I that can restore forward activity in the same manner as hypoxia.
PURPOSE: To investigate the safety of transurethral ureteroscopy (URS) for urolithiasis in bedridden patients and to identify bedridden patient-specific risk factors for postoperative complications.
METHODS: The patients who underwent URS for urolithiasis were divided into bedridden patients and good performance status (PS) patients, and the groups were compared regarding their clinical characteristics and postoperative complications. A multivariable logistic regression analysis was performed to evaluate independent predictors of postoperative febrile urinary tract infection (fUTI).
RESULTS: A total of 1626 patients were included, 276 in the bedridden patient group, and 1350 in the good PS patient group. The bedridden patient group had a significantly higher age and higher proportion of females and had multiple comorbidities. In 77 patients (27.9%), 88 postoperative complications developed for the bedridden patient group. Clavien-Dindo grade III or IV complications were observed in only 8 patients. No grade V complications were observed. The most common complication was fUTI. The frequency of fUTI with grade III or IV for the bedridden patient group (2.2%) was higher compared with the good PS patient group (0.5%), but the difference was not statistically significant (p = 0.13). Bedridden patient-specific risk factors for fUTI included female sex, diabetes mellitus, cerebrovascular comorbidities, lower extremity contracture, and prolonged operative time.
CONCLUSION: URS for urolithiasis is a feasible and acceptable procedure in bedridden patients, despite the moderate rate of postoperative complications. The identified risk factors provide a framework for risk stratification and individualized care in this unique patient population.
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.
Sham dry needling (SDN). All participants in this group received one session of SDN with a 25 mm X 0.22 mm JEMCO acupuncture needle over the infraspinatus region. To ensure that the blunt needles did not puncture the skin during the experimental session (and for patient comfort), each needle was individually cut and polished and checked for sharpness against the investigator's fingertip. As a precaution against infection, each patient was treated with a separate dummy needle.
Half of the world's population is infected with Helicobacter pylori. Strong evidence supports that H.pylori eradication is an effective approach to reduce the risk of developing gastric cancer. However, eradication rates of first-line therapy decreased over years due to the rapidly emerging antibiotic resistance of H. pylori worldwide. An ideal rescue therapeutic regimen to cure refractory H.pylori infection is currently warranted. Traditional sequential therapy failed to achieve an ideal eradication rates (over\>95%) as a third line treatment in the region with high antibiotic resistance. This study aims to evaluate the efficacy of 14-day modified sequential therapy in the patients with two or more treatment failure, and whether the adverse effects of this new modified sequential therapy are tolerable. Then, this study will also compare the performance of a double-dose esomeprazole with double-dose rabeprazole containing therapy to optimize therapeutic regimen.
This is a prospective cohort observational registry study that will include data on all patients who are treated at MHS facilities for COVID-19. Data including, but not limited to demographics, comorbidities, medications, treatment, and clinical outcomes will be collected from February 2020 to December 2025. Subjects will undergo no additional tests or procedures as part of this registry study. All patient data will be obtained from the patient's electronic health records (EHR) of the hospital or clinic in a retrospective manner. The process for gathering the data will not influence treatment decisions. There will be no direct patient contact associated with inclusion in this registry study.
PROBLEM TO BE SOLVED: To provide an automatic hand washing system with ozone water by which a sure sterilization is performed by simply extending hands or fingers while the ozone water is being discharged, and at the same time, of which the appearance is not spoiled, and which can effectively utilize an already existing installation place, and does not need a special management for a chemical liquid or the like. SOLUTION: This automatic hand washing system with ozone water has an ozone water manufacturing unit 15, a hand washing sink 2, a faucet 1, and a hand washing unit 16. In this case, the ozone water manufacturing unit 15 obtains the ozone water by dissolving an ozone gas from an ozone generating unit with supply water which is fed through an electromagnetic valve. The faucet 1 discharges the ozone water. The hand washing unit 16 is set in the vicinity of the faucet, and is equipped with a hand washing detecting sensor 8 which detects the approaching of articles to be washed such as hands or fingers. The ozone water manufacturing unit is arranged under the hand washing sink. Then, the ozone water of a specified concentration is automatically fed from the faucet for a specified period of time by the detecting signal of the hand washing detecting sensor.
Therapy with SUBVENITE increases the risk of developing aseptic meningitis. Because of the potential for serious outcomes of untreated meningitis due to other causes, patients should also be evaluated for other causes of meningitis and treated as appropriate.

Postmarketing cases of aseptic meningitis have been reported in pediatric and adult patients taking SUBVENITE for various indications. Symptoms upon presentation have included headache, fever, nausea, vomiting, and nuchal rigidity. Rash, photophobia, myalgia, chills, altered consciousness, and somnolence were also noted in some cases. Symptoms have been reported to occur within 1 day to one and a half months following the initiation of treatment. In most cases, symptoms were reported to resolve after discontinuation of SUBVENITE. Re-exposure resulted in a rapid return of symptoms (from within 30 minutes to 1 day following re-initiation of treatment) that were frequently more severe. Some of the patients treated with SUBVENITE who developed aseptic meningitis had underlying diagnoses of systemic lupus erythematosus or other autoimmune diseases.

Cerebrospinal fluid (CSF) analyzed at the time of clinical presentation in reported cases was characterized by a mild to moderate pleocytosis, normal glucose levels, and mild to moderate increase in protein. CSF white blood cell count differentials showed a predominance of neutrophils in a majority of the cases, although a predominance of lymphocytes was reported in approximately one third of the cases. Some patients also had new onset of signs and symptoms of involvement of other organs (predominantly hepatic and renal involvement), which may suggest that in these cases the aseptic meningitis observed was part of a hypersensitivity reaction [see Warnings and Precautions (5.3)].
OBJECTIVE: This study aims to evaluate the outcomes of open reduction and internal fixation (ORIF) for chronic perilunate dislocations using single-stage, two-stage, and salvage procedures. The study also compares these approaches with each other and with results from existing literature.
METHODS: A total of 15 patients with chronic perilunate injuries from 2013 to 2019 were included in the study. Pre-operative and post-operative assessments were conducted using plain radiographs, with CT scans performed selectively for detailed morphology and fracture pattern analysis. Among the patients, 13 underwent ORIF, while 2 underwent salvage procedures. Among the ORIF cases, single-stage procedures were performed in 4 patients, and two-stage procedures in 9 patients. External fixators, including unilateral uniplanar external fixators (UUEF) and bilateral uniplanar external fixators (BUEF), were applied in 5 and 4 patients, respectively. Our methodology of treating chronic perilunate injuries has evolved over the years. We started with single stage ORIF then graduated to a two staged procedure initially using a external fixator as a carpal distractor applied only on the radial side and finally settling down with bilateral carpal distraction using external fixators both on the radial and ulnar sides.
RESULTS: Among the 15 patients, 3 were lost to follow-up. Of these, one underwent four-corner fusion, while the remaining two had UUEF. The mean time interval between injury and surgery was 3.60 months. The post-operative mean scapholunate angle measured 52.46°, with a negative radio-lunate angle (indicating flexion) observed in two patients, while others showed a positive angle (indicating extension). Two cases exhibited nonunion and avascular necrosis (AVN) of the scaphoid, while one case presented with lunate AVN. Mid-carpal and radio-carpal arthritis was observed in 4 and 2 patients, respectively. Functional outcomes were evaluated using Mayo's wrist score categorized as good for two-stage BUEF cases and satisfactory for UUEF and single-stage procedures.
CONCLUSION: Staged reduction utilizing the BUEF followed by open reduction has demonstrated superior outcomes when compared to UUEF, single-stage open reduction and salvage procedures.
LEVEL OF EVIDENCE: 4.