anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study is to demonstrate the feasibility of novel MRI-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam radiotherapy delivered using a LINAC (linear accelerator) radiation therapy device. The investigators have previously demonstrated that ultrasound and microbubble mediated endothelial cell perturbation can significantly enhance the effectiveness of radiation. It enhances tumour response to radiation significantly by synergistically destroying tumour blood vessels. The technique is targeted spatially and achieves tumour specificity by confining the low-power ultrasonic fields that stimulate microbubbles to the tumour location only. By perturbing the tumour vasculature and activating specific genetic pathways, the technique sensitizes the targeted tissues to the subsequent therapeutic application of radiation, resulting in significantly enhanced cell killing. The primary aim of this research is to evaluate the safety profile of MRI-guided ultrasound stimulated microbubble treatment and radiation in patients with head and neck cancer. The secondary aim is to evaluate tumor (primary and/or nodal) response to MRg-FU + MB and radiation, as measured radiologically within the treated therapeutic regions.
PURPOSE:To provide an antimicrobial compsn. with high processability and being inexpensive for providing excellent antimicrobial characteristics to various products for medical uses. CONSTITUTION:The title product is a medical product wherein antimicrobial characteristics are provided by a antimicrobial compsn. prepd. by dispersing an antimicrobial substance wherein an antimicrobial metal e.g. silver, copper and/or zinc is adsorbed by using a porous titanium as a supporting body in a dispersing medium. In this antimicrobial substance, the surface, area of the porous titanium is 100cm<2>/g or larger; when the adsorbed antimicrobial metal is silver single component, the wt. ratio of silver component to titanium component (Ag/Ti) is about 0.6X10<-2> or larger; when the adsorbed antimicrobial metals are composite components wherein silver component and copper and/or zinc components are main components, in the region where the amt. of silver component (As/Ti) is about 0.6X10<-2> or larger, the amt. of copper component and/or zinc component are about 1X10<-2> or larger.
OBJECTIVES: With a projected rise in care home residency and the disproportionate impact of epilepsy and seizures on older adults, understanding seizure-related needs in this population is crucial. Data silos and inconsistent recording of residence status make this challenging. We thus leveraged ambulance data to investigate seizure call-out incidence, characteristics, management and costs in care homes compared with the wider community.
DESIGN: Retrospective analysis of dispatch data from a regional English ambulance service over four 9-month periods between 2014/2015 and 2021/2022. Suspected seizures in adults (≥16 years) were identified, with data on location, patient age, severity and management extracted. Incidence rates, trends over time and case characteristics were compared. Costs of ambulance response were estimated, and factors influencing emergency department (ED) conveyance were analysed using logistic regression.
SETTING: North West Ambulance Service National Health Service Trust, serving an adult population of ~5.5 million.
PARTICIPANTS: Dispatch data for 98 752 suspected seizure cases.
RESULTS: Care homes, accommodating ~0.8% of the regional population, accounted for 7.2% of seizure call-outs. Incidence was higher in care homes than the wider community (55.71 vs 5.97 per 1000 person/year in 2021/2022) and increased over time. Care home cases peaked around 8:00-9:00. Despite similar or lower severity, they had a higher ED conveyance rate (78.3% vs 70.6%). Conveyance likelihood was influenced by factors beyond severity: reduced in homes specialising in learning disabilities (adjusted OR=0.649) and increased in homes with nursing provision (adjusted OR=1.226). Care homes accounted for 7.26% of the £24 million cost.
CONCLUSIONS: This study highlights the growing seizure-related needs in care homes. Despite similar severity, most cases result in ED conveyance. Future research should examine the appropriateness and implications of these transfers, ensuring specialist services support the care home population effectively.
PURPOSE: A pharmaceutical or cosmetic composition for eyelash growth is provided to be directly applied to eyelashes and to promote eyelash growth. CONSTITUTION: A composition for eyelash growth contains nipradilol or pharmaceutically acceptable salts thereof as an active ingredient. The composition additionally contains prostaglandin analogue compounds. The prostaglandin analogue compound is prostaglandin F2alpha analogue compounds. The prostaglandin analogue compound includes latanoprost, unoprost, unoproston isopropyl, bimatoprost, travoprost, tafluprost, carboprost, or a pharmaceutically acceptable salt thereof. The composition is directly applied on eyelashes. [Reference numerals] (AA) Number of eyelashes; (BB) Control; (CC) Nipradilol; (DD) Bimatoprost
Sixty healthy, elderly volunteers between the ages of 55 and 85 will be enrolled at one of four clinical sites in the Tampa/St. Petersburg area. Subjects with a history of GI inflammatory conditions (e.g., IBS or diverticulitis) or other clinically significant abnormalities will be excluded from enrollment. Subjects will be randomized to one of two dosing regimens (with or without a 7-day titration period) and to one of three formulations of Ketasyn containing the identical amount of active ingredient, but different amounts of proteins and carbohydrates. Subjects assigned to Group 1 will receive 10 grams active ingredient daily on Days 1-7, followed by a daily dose of 20 grams active ingredient on Days 8-14. Subjects assigned to Group 2 will receive 20 grams active ingredient on Days 1-14. All subjects will have clinic visits on Day 1 and 14; subjects assigned to Group 1 will also have a clinic visit on Day 8. Subjects will fast prior to each clinic visit and have vital signs and routine lab tests performed prior to dosing. A standard breakfast will be served along with the study product, following which blood samples will be collected for product concentration levels.
BACKGROUND: Refeeding syndrome is characterized by metabolic and electrolyte alterations that result from the initiation of feeding after a period of inadequate caloric intake. Especially, in the elderly with acute and/or chronic illness, nutritional deficiencies are common, and diminished oral intake with effects of catabolic status yields malnutrition. This study was conducted to evaluate refeeding hypophosphatemia and its consequences on outcomes in the oldest old critically ill patients.
METHODS: This study was designed as a retrospective cohort study that included patients who were 80 years old or older admitted to ICU. Patients were grouped depending on whether hypophosphatemia occurred after 48 hours of admission who started feeding.
RESULTS: The median age of all patients was 87[82-90] years and 61(73%) of them were female. Refeeding hypophosphatemia was observed in 25(30%) patients. When patients were grouped depending on the occurrence of hypophosphatemia, groups were similar according to the severity scores, and comorbidities. Neither ICU mortality nor hospital mortality was different between groups (p=0.76 and p=0.19, respectively).
CONCLUSION: Refeeding hypophosphatemia incidence was similar to previous studies, although study patients were the highest risk group. Outcome parameters including mortality rate and length of ICU stay were not different between patients with or without refeeding hypophosphatemia.
The invention belongs to the field of ethnic minority medicines and discloses an externally used Yao medicine composition for treating cystic hyperplasia of breasts and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 3-30 parts of root of clematis chinensis osbeck, 3-30 parts of whole plant of polygonum cuspidatum Sieb.et Zucc., 3-30 parts of whole plant of plumbago zeylanica L. and 3-30 parts of herb of leonurus artemi sia(Lour.)S.Y.Hu. The dosage form of the composition is powder. The composition is mixed with medicinal liquor and is applied or is prepared into worn medicine bags. The preparation method comprises the processes of grinding, baking and sterilizing the raw medicines, thus preparing the powder. Clinical tests show that the Yao medicine composition has the specific functions of clearing and activating the channels and collaterals, dissipating stasis to relieve pains, reducing phlegm and softening hardness and removing stasis for promoting tissue regeneration, can soften and remove cystic hyperplasia of breasts, has definite, quick and stable curative effects, does not have toxic or side effect and is a good medicine for treating cystic hyperplasia of breasts.
The invention provides a prescription for treating asthma. The prescription comprises, by weight, 12g of panax notoginseng, 18g of fructus forsythiae, 10g of radix aconiti, 8g of fritillaria cirrhosa, 8g of angelica sinensis, 8g of fritillaria thun-bergli, 6g of rhizoma coptidis, 6g of salviae miltiorrhizae, 30g of raw gypsum and 15g of empirical formula comprising fructus schizandrae, fructus lycii and semen ziziphi spinosae. The prescription is suitable for patients with the asthma caused by various conditions and has special curative effects of clearing away heat and toxic materials, relieving swelling and pain, removing necrotic tissue and promoting granulation and astringing to stop bleeding. When the prescription is used correctly, periodontal microcirculation can be dredged, periodontal and gum immunity can be enhanced, tooth calcification can be promoted, periodontium and alveolar bone physiological function can be recovered, and tooth fixing and gum protection can be achieved. The prescription is good medicine for treating the lymphoma. The prescription is good medicine for treating the asthma.
The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS. The sample was composed by patients with HIV/AIDS of both sexes. The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise. The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress. For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise). Level of significance adopted was P \< 0,05.
In this group, intravenous patient-controlled-analgesia morphine was used. Morphine solution was prepared at a concentration of 0.5 mg/mL with the device programmed to 2 mg of bolus dose and 10 min of locking time.
Excessive hypotension was rarely seen in uncomplicated hypertensive patients but is a possible consequence of lisinopril use in salt/volume-depleted persons, such as those treated vigorously with diuretics or patients on dialysis. (See PRECAUTIONS , Drug Interactions and ADVERSE REACTIONS .)

Syncope has been reported in 0.8 percent of patients receiving lisinopril and hydrochlorothiazide. In patients with hypertension receiving lisinopril alone, the incidence of syncope was 0.1 percent. The overall incidence of syncope may be reduced by proper titration of the individual components. (See PRECAUTIONS , Drug Interactions, ADVERSE REACTIONS  and DOSAGE AND ADMINISTRATION .)

In patients with severe congestive heart failure, with or without associated renal insufficiency, excessive hypotension has been observed and may be associated with oliguria and/or progressive azotemia, and rarely with acute renal failure and/or death. Because of the potential fall in blood pressure in these patients, therapy should be started under very close medical supervision. Such patients should be followed closely for the first two weeks of treatment and whenever the dose of lisinopril and/or diuretic is increased. Similar considerations apply to patients with ischemic heart or cerebrovascular disease in whom an excessive fall in blood pressure could result in a myocardial infarction or cerebrovascular accident.

If hypotension occurs, the patient should be placed in supine position and, if necessary, receive an intravenous infusion of normal saline. A transient hypotensive response is not a contraindication to further doses which usually can be given without difficulty once the blood pressure has increased after volume expansion.
PURPOSE: Abdominal para-aortic lymph nodes (PANs) are sites of distant metastasis in esophageal squamous cell cancer (ESCC). The prognosis of patients with Stage IVB ESCC and abdominal PAN metastasis is extremely poor. However, chemotherapy for ESCC has recently been developed, and the effectiveness of combined induction therapy and conversion surgery remains unclear. The primary objective of this study was to evaluate the short- and long-term outcomes of conversion surgery for ESCC and solitary abdominal PAN metastases after induction therapy.
METHODS: Thirteen patients who underwent conversion esophagectomy for cStage IVB ESCC with solitary abdominal PAN metastasis after induction therapy between January 2017 and October 2022 at our institution were enrolled. The short- and long-term outcomes of conversion surgery were retrospectively evaluated.
RESULTS: Three patients (23.1%) had pathological abdominal PAN metastasis, and six patients (46.2%) without pathological abdominal PAN metastasis showed that chemotherapy eliminated the tumors in the abdominal PAN. Three patients (23.1%) had postoperative complications of Clavien-Dindo grade II or higher. The 3-year overall and recurrence-free survival rates were 83.1% and 51.3%, respectively.
CONCLUSIONS: Our findings showed that conversion surgery for ESCC and solitary abdominal PAN metastasis led to a good prognosis when induction therapy was successful.
Cervical Total Disc Replacement (Cervical TDR) arthroplasty with the DISCOVER™ Artificial Cervical Disc at a single level or multiple levels of the cervical spine, C3 to C7 inclusive. Training cohort.
Many schizophrenia outpatients have cognitive deficits and poor vocational functioning. There is evidence from randomized controlled trials that vocational skills training is important in improving vocational role functioning for schizophrenia patients. However, it has become clear that cognitive impairments limit the ability of patients to benefit from skills training approaches. Recent research demonstrates that patients switched from olanzapine to aripiprazole improve in terms of verbal learning. Verbal learning has been found to be a strong predictor of multiple domains of community outcome. It is unclear whether the cognitive benefits of switching to aripiprazole extend to improve learning of vocational skills. This study examines whether aripiprazole can improve the ability to benefit from expensive rehabilitation programs focused on skill-building. Specifically, the study examines whether patients who switch from olanzapine to aripiprazole learn more and benefit more from a brief vocational skills program than patients who remain on olanzapine. Specific aims are as follows: (1) we hypothesize that patients on aripiprazole will demonstrate better scores on tests of cognitive functioning following twelve weeks of medication treatment than patients on olanzapine and (2) we hypothesize that patients on aripiprazole will have significantly higher scores on vocational performance following a brief (2-day) vocational training and assessment session than those on olanzapine. Furthermore, we hypothesize that these gains will be maintained following one week of non-exposure to the trained vocational tasks.
A nulligravida in her 30s presented with primary infertility and secondary amenorrhoea. General examination revealed virilisation; sonological examination detected a right ovarian solid mass. International Ovarian Tumour Analysis (IOTA) was suggestive of malignancy and serum testosterone was raised. A strong clinical suspicion and negative tumour markers pointed towards androgen producing sex cord stromal ovarian neoplasm. MRI excluded pelvic lymphadenopathy. Given the patient's desire for conception, fertility sparing staging laparotomy was done. Histopathology confirmed Sertoli-Leydig cell tumour (SLCT) International Federation of Gynaecology and Obstetrics stage IA. Serum testosterone fell drastically by day 10. Spontaneous menstruation resumed within 30 days. The significance of SLCTs as a differential diagnosis in young women with secondary amenorrhoea and virilising features underscores the role of fertility-preserving surgery in certain circumstances. Here we discuss the clinical features, diagnostic challenges and management strategies for SLCTs, emphasising the need for multidisciplinary collaboration and option of fertility preservation in early stages.
The United Kingdom (UK) is one of the first countries that introduced a mass vaccination campaign for COVID-19 and vaccination of the adult population first focused on the oldest age groups, their carers and health care workers (JCVI, 2020). Three COVID-19 vaccines were licensed and are being used including the Moderna, the BioNTech/Pfizer, and the Oxford/AstraZeneca vaccines. Vaccination with the BioNTech/Pfizer vaccine started in December 2020 and the Oxford/AstraZeneca vaccine started in early January 2021. This study is to primarily assess the effectiveness of the Oxford/AstraZeneca COVID-19 vaccine. Given the known high efficacy of the mRNA vaccines in randomized controlled trials (RCTs) and real-world evidence studies, the study aims also to evaluate the vaccine effectiveness (VE) of other COVID-19 vaccines as a validation of the study's methods. On 16 September 2021 it was announced that Booster doses would be introduced in the UK to address vaccine waning and for groups with a suboptimal response. Little is known about health care resource utilisation (HCRU) and health care costs for those who have had COVID-19 or by individual clinical risk group. The RAVEN study is a retrospective cohort study to assess the real-world effectiveness of the Oxford/AstraZeneca COVID-19 vaccine in England. The study is using linkage of the English national databases on COVID-19 vaccination, testing, medical records, hospitalization, and death. Analyses will examine the effectiveness of one and two doses, and booster or other additional doses if applicable. This study's extension (October 2021) adds a more detailed exploration of VE in risk groups and an evaluation of the HCRU by people with COVID-19 compared with those who are vaccinated.
A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to a given pathogenic virus having a tropism which is specific for said cells. Cells uninfected with the virus, particularly a retrovirus such as HIV, contain a genetic sequence of which the expression product (e.g. HSV1-TK-) may, when its production is increased so that it is present in a sufficient quantity within said trapped cells, react in situ with a pharmaceutically active substance (e.g. acyclovir in the above mentioned example) to induce the destruction of the cells and of means which are specifically induced by a signal provided by the pathogenic virus (e.g. the long terminal repeat of the retrovirus) when it enters the cells, to cause the aforesaid increased production. The use of said pharmaceutically active substance to produce active drugs preventing infection by said virus, is also described.
The objective of the study is to assess the Tpe and QTc measures in 24 hr Holter echocardiograms in patients treated with atypical antipsychotic drgs (APDs). The primary comparisons of interest are olanzapine (no QTc prolongation) to ziprasidone (QTc prolongation) and thioridazine (QTc prolongation) as well as ziprasidone (possibly low TdP risk) to thioridazine (TdP risk). Secondary comparisons will be among all APDs available. In a previously approved study, conventional 24 hr Holter electrocardiograms were recorded from a total of 78 subjects during the course of treatment with psychotropic medications and without medication (in the case of normals and unmedicated patients). These recordings will be analyzed to yield Tpe, QTc and heart rate, and other measures. Data from additional patients is needed, therefore this study will include only patients currently treated with Mellaril (thioridazine), Risperdal (risperidone) and Seroquel (quetiapine).
FIELD: microbiology, biochemistry. SUBSTANCE: strains of three serovara (Inaba, Ogawa, 0139) are grown under conditions of submerged culturing and additional feeding with glucose and ammonia. The native preparation of 0-antigen is obtained that is excreted in cultural medium spontaneously. Inert proteins are removed by their precipitation at pH 4.4 ± 0.2 and nonspecific impurities (molecular mass is less 100 kDa) are concentrated and separated by ultrafiltration. Nonspecific impurities (molecular mass is less 300 kDa) are separated by column chromatorgaphy being at all stages of purification 0-antigen is retained in the monophase dissolved state. The concentrated solution of 0-antigen is lyophilized in ampoules. One ampoule has 5 ± 0.5 mg of dry preparation, 250-500 conventional antigen doses equal to reverse titer in RPGA with 0-serum (choleraic or against 0139 strain) depending on serovarum. Protein content is 7-8% (by Lowry). Toxicity in white mice by LD 50  is 2 ± 0.5 mg. The preparation shows homogeneity by data of high-performance liquid chromatography. Invention ensures to obtain highly purified, good soluble 0-antigen of cholera vibrio 01 serovara (Inaba, Ogawa) and showing epidemically significance nonagglutinating (NAG) vibrio 0139 serovara. Invention can be used for specific identification and diagnosis of cholera caused by pathogens of three serovara: Inaba, Ogawa and 0139. EFFECT: improved method of 0-antigen preparing. 3 dwg
Research on the role of the hippocampus in memory acquisition has generally focused on active learning. But to understand memory, it is at least as important to understand processes that happen offline, during both wake and sleep. In a study of patients with amnesia, we previously demonstrated that although a functional hippocampus is not necessary for the acquisition of procedural motor memory during training session, it is required for its offline consolidation during sleep. Here, we investigated whether an intact hippocampus is also required for the offline consolidation of procedural motor memory while awake. Patients with amnesia due to hippocampal damage (n = 4, all male) and demographically matched controls (n = 10, 8 males) trained on the finger tapping motor sequence task. Learning was measured as gains in typing speed and was divided into online (during task execution) and offline (during interleaved 30 s breaks) components. Amnesic patients and controls showed comparable total learning, but differed in the pattern of performance improvement. Unlike younger adults, who gain speed across breaks, both groups gained speed only while typing. Only controls retained these gains over the breaks; amnesic patients slowed down and compensated for these losses during subsequent typing. In summary, unlike their peers, whose motor performance remained stable across brief breaks in typing, amnesic patients showed evidence of impaired access to motor procedural memory. We conclude that in addition to being necessary for the offline consolidation of motor memories during sleep, the hippocampus maintains access to motor memory across brief offline periods during wake.