anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Previous studies have shown a clear link between insulin resistance (IR) and an elevated risk of atrial fibrillation (AF). However, the relationship between the estimated glucose disposal rate (eGDR), which serves as a marker for IR, and the risk of AF recurrence after radiofrequency catheter ablation (RFCA) remains uncertain. Therefore, this study aimed to examine the potential association between the eGDR and the risk of AF recurrence following RFCA.
METHODS: This retrospective study was conducted at Nanchang University Affiliated Second Hospital. The study enrolled 899 patients with AF who underwent RFCA between January 2015 and January 2022. The formula used to calculate the eGDR was as follows: 19.02 - (0.22 * body mass index) - (3.26 * hypertension) - (0.61 * HbA1c). Cox proportional hazard regression models and exposure-effect curves were used to explore the correlation between the baseline eGDR and AF recurrence. The ability of the eGDR to predict AF recurrence was evaluated using the area under the receiver operating characteristic curve (AUROC).
RESULTS: The study observed a median follow-up period of 11.63 months, during which 296 patients experienced AF recurrence. K‒M analyses revealed that the cumulative incidence AF recurrence rate was significantly greater in the group with the lowest eGDR (log-rank p < 0.01). Participants with an eGDR ≥ 8 mg/kg/min had a lower risk of AF recurrence than those with an eGDR < 4 mg/kg/min, with a hazard ratio (HR) of 0.28 [95% confidence interval (CI) 0.18, 0.42]. Additionally, restricted cubic spline analyses demonstrated a linear association between the eGDR and AF recurrence (p nonlinear = 0.70). The area under the curve (AUC) for predicting AF recurrence using the eGDR was 0.75.
CONCLUSIONS: The study revealed that a decrease in the eGDR is associated with a greater AF recurrence risk after RFCA. Hence, the eGDR could be used as a novel biomarker for assessing AF recurrence risk.
There is no in-person training or POC instructional interventions for this group for c-collar application attempt. Participants repeat the c-collar application without any in-person training or POC instructional interventions at 2 months follow-up.
The invention discloses a traditional Chinese medicine composition for treating senile duodenal ulcer, and belongs to the technical field traditional Chinese medicines. Traditional Chinese medicines including roots of Nupharpumilum(Timm)DC. , Saussurea deltoidea, roots of Vernonia squarrosa (D. Don) Less. var. orientalis Kitam.[V. teres auct. non DC.], all grass of Aleuritopteris hopeana (C. Chr.) Ching, roots of Chinese honeysuckle, seeds of Castanopsis hystrix A.DC., all grass of Crepis turczaninowii C. A. Mey., Goodyera schlechtenda- liana Reichb.f G.repens(L.) B. Br, Adenophora paniculata, all grass of bieberstein carlina and roots or tender leaves of Vicia unijuga which have the functions of warming middle-jiao and tonifying deficiency and replenishing qi to invigorate spleens are selected for pathogenesis of senile duodenal ulcer according to the symptomatic treatment principle of traditional Chinese medicines and decocted into decoction, and it is proved through clinical tests that the total effective rate reaches 98%.
PURPOSE: A moisture mask pack with improved intensity and elasticity and a manufacturing method thereof are provided to increase physical strength of the composition of the mask pack. CONSTITUTION: A manufacturing method of a moisture mask pack is as follows. A calcium lactate aqueous solution is prepared by adding 0.01-3 weight% of calcium lactate to 60-90 weight% of purified water and stirring the calcium lactate and purified water. Three elements selected from 5-30 weight% of glycerine, 0.1-3 weight% of xanthan gum, 0.1-3 weight% of tamarind gum, 0.1-3 weight% of ceratonia silica gum, 0.1-3 weight% of carrageenan, 0.05-3 weight% of arabian gum, and 0.01-3 weight% of gellan gum are mixed and stirred. Hydrosol is prepared by mixing the calcium lactate solution with gel composition and mixing the mixture thereof. A mask pack composition is prepared by adding 0.01-5 weight% of a functional additive to hydrosol, stirring the mixture thereof, and defoaming for 10-20 minutes. A mask pack film is manufactured by coating a thin film with the mask pack composition and cooling the film. The mask pack film is cut into a face shape.
The present invention relates to a composition, and a method for preventing or reducing contact dermatitis. The composition contains a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material. The present invention is further a dermatologically-compatible barrier film for preventing and reducing contact dermatitis which contains a polysaccharide; a low molecular weight, synergistic saccharide; and optionally one or more additives. The dermatologically-compatible barrier film is formed of a composition containing a polysaccharide; a low molecular weight, synergistic saccharide; a solvent; and optionally an additive material. The composition is a skin care product in a form of a lotion, a gel or a cream that is applied to skin of mammals. Once applied, the solvent in the composition evaporates, and thereby leaves behind a dermatologically-compatible barrier film containing a polysaccharide; a low molecular weight, synergistic saccharide; and optionally an additive material.
The invention relates to a compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes. The compound traditional Chinese medicine preparation is prepared from the following components: unprepared rehmannia roots, honeysuckles, fructus forsythiae, herba violae, figwort roots, rhubarbs, baikal skullcap roots and liquorice roots. The compound traditional Chinese medicine is prepared by the following steps: weighing the components in parts by weight, adding the components into a smasher respectively, smashing the components, sieving, mixing, and sieving. When in use, the compound traditional Chinese medicine is mixed with a feeder according to a certain proportion, and then a powdery bonding agent is added into the mixture of the compound traditional Chinese medicine and the feeder to form a medicinal bait. The medicinal bait needs to be aired before being fed to fishes. After the fishes are fed by the medicinal bait continuously for a period of time, the disease of the fishes can be controlled gradually, the appetite of the fishes can return to be normal, and the observation on the dissected fish shows that the upper jaw, lower jaw, oral cavity, branchial mantle, eyes and abdomen of the fish return to be normal, the color of the back of the fish becomes normal. The fishes fed by the preparation can grow well, no medicine is left, and side and toxic effects do not exist.
PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate having the following formula:   <IMAGE>   A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65 DEG  C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, interferon-inducing and immunomodulatory effects.
OBJECTIVES: This study aimed to explore the effects of cerebral oxygenation, body temperature, hemodynamic changes, and anesthesia type on postoperative cognitive dysfunction (POCD) in geriatric patients undergoing hip fracture surgery.
PATIENTS AND METHODS: One hundred five elderly patients (59 males, 46 females; mean age: 76.7±8.8 years; range, 65 to 95 years) who were scheduled for hip fracture surgery under general or spinal anesthesia between March 2021 and March 2023 were enrolled in the prospective observational study. The cognitive functions were evaluated using the Mini-Mental State Examination (MMSE). Postoperative MMSE values <24 were considered indicative of POCD. Cerebral oxygenation was evaluated before and during the operation using near-infrared spectroscopy (NIRS), and body temperature was measured using a tympanic thermometer, with values <36℃ considered hypothermia. The relationship between decreases in blood pressure ≥30% and POCD was investigated. The relationship between decreases in NIRS of 25% and POCD was also investigated.
RESULTS: Postoperative cognitive dysfunction was observed in 29 (27.25%) of the 105 patients. The MMSE value was 24 in 67.06% of 29 patients, and all these patients developed POCD. The incidence of POCD in patients with a preoperative MMSE1 score of 30 was 12.30% (p=0.001). No relationship was identified between MMSE changes and anesthesia type, hypotension, and decreases in the NIRS (p=0.439, p=0.399). Hypothermia was found to be significantly related to POCD (p=0.013). The degree of hypothermia decreased the postoperative MMSE value at different rates. A 1°C body temperature decrease caused a 16.7%, 44.4%, and 50% decrease in MMSE scores of one, one, and two patients, respectively.
CONCLUSION: Hypothermia was found to be significantly related to POCD. The same degree of hypothermia caused different MMSE changes. Since the number of patients with POCD was very low, the effect of amounts of body temperature changes on clinically significant MMSE changes could not be supported by logistic regression. The preoperative MMSE values, MMSE change rates, and age were found to be effective in POCD. Maintaining the body temperature throughout the operation will ensure the preservation of postoperative cognitive functions.
A composition of treating cell of an ischemic limb disease is provided to flow blood smoothly by containing a stem cell derived from adipose and generating new vessels to closed perivenular and to cure an ischemic limb disease effectively. A composition of treating cell of an ischemic limb disease contains a mesenchyme stem cell derived from a fatty tissue and an excipient. A concentration of mesenchyme stem cell derived from a fatty tissue is 10^5~ 10^8 cell/mL. The excipient is a sucrose or a mannose. A base of the composition is selected in a group consisting of saline solution, phosphate buffered saline and Hartmann-D. The composition additionally contains albumin or blood serum to the excipient.
A standardized CIMT protocol will be administered over a three week period. The first week will consist of wearing a below elbow cast on the non-hemiplegic limb followed by a two week CIMT camp (5 hours per day, 5 days per week) where the child/youth wears a constraint splint on the non-hemiplegic hand. The two week camp will follow a standardized CIMT camp protocol ("Hand2Hand" developed at HBKRH) that includes activities that focus on unilateral hemiplegic hand activity in the first week and increasing incorporation of bilateral hand activities in the second week. The camp protocol for CIMT is based on camp protocols utilized successfully in other paediatric research studies.
Methylprednisolone acetate injectable suspension, USP is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available as single dose vials in two strengths: 40 mg/mL; 80 mg/mL.

Each mL of these preparations contains:

The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6α, 11β)- and the molecular weight is 416.51. The structural formula is represented below:

Methylprednisolone acetate sterile injectable suspension, USP contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, in alcohol, in chloroform, and in methanol, and slightly soluble in ether. It is practically insoluble in water.
As with any NSAID, caution should be exercised in treating the elderly (65 years and older). Clinical experience with flurbiprofen suggests that elderly patients may have a higher incidence of gastrointestinal complaints than younger patients, including ulceration, bleeding, flatulence, bloating, and abdominal pain. To minimize the potential risk for gastrointestinal events, the lowest effective dose should be used for the shortest possible duration (see WARNINGS: Gastrointestinal Effects). Likewise, elderly patients are at greater risk of developing renal decompensation (see WARNINGS: Renal Effects). 

The pharmacokinetics of flurbiprofen do not seem to differ in elderly patients from those in younger individuals (see CLINICAL PHARMACOLOGY: Special Populations). The rate of absorption of flurbiprofen was reduced in elderly patients who also received antacids, although the extent of absorption was not affected (see CLINICAL PHARMACOLOGY: Drug-Drug Interactions).
Ramipril can cause symptomatic hypotension, after either the initial dose or a later dose when the dosage has been increased. Like other ACE inhibitors, ramipril has been only rarely associated with hypotension in uncomplicated hypertensive patients. Symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. Volume and/or salt depletion should be corrected before initiating therapy with ramipril.

In patients with congestive heart failure, with or without associated renal insufficiency, ACE inhibitor therapy may cause excessive hypotension, which may be associated with oliguria or azotemia and, rarely, with acute renal failure and death. In such patients, ramipril therapy should be started under close medical supervision; they should be followed closely for the first 2 weeks of treatment and whenever the dose of ramipril or diuretic is increased.

If hypotension occurs, the patient should be placed in a supine position and, if necessary, treated with intravenous infusion of physiological saline. Ramipril treatment usually can be continued following restoration of blood pressure and volume.
The present invention relates to apparatus for automatic quantification of a part of vascular structure. It is described to provide (12) at least one first image comprising a spatial representation of a region of interest of a vascular structure, wherein the at least one first image comprises image data representative of a location of a part of a medical device. The medical device is configured to be used in a vascular treatment, and the part of the medical device is configured to be in a plurality of states associated with different phases of the vascular treatment. At least one second image comprising a spatial representation of the region of interest of the vascular structure is provided (14), wherein the at least one second image comprises image data representative of at least a part of the vascular structure in a visible and distinct manner. A location of a feature in the spatial representation of the region of interest of the vascular structure of the at least one first image is determined (18), wherein the feature is associated with the part of the medical device in one of the states associated with a phase of the vascular treatment. A transform relating at least one location in the at least one first image to a corresponding at least one location in the at least one second image is determined (20) and applied to the location of the feature in the spatial representation of the region of interest of the vascular structure of the at least one first image to provide a determined location in the spatial representation of the region of interest of the vascular structure of the at least one second image. Data is output (22) representative of the vascular structure at the determined location.
The invention relates to an ointment for the treatment of eczema and neurodermatitis, and concretely relates to an etofesalamide ointment. The ointment comprises a therapeutically effective amount of the etofesalamide ointment, and pharmaceutically acceptable excipients; and the ointment further comprises a hydrophilic gel material and a skin penetration enhancer. The hydrophilic gel material is carbomer resin, and the skin penetration enhancer is macrogolglyceride. Compared with the prior art, the technology improves penetration rate of the drug through skin. The ointment prepared by the technology has the characteristics of being not greasy and easy to clean, and does not affect the normal function of the skin, can promote the excretion of eczema secretion, and thereby significantly improves compliance of patients. The technology is simple and feasible, and easy to realize.
OBJECTIVES: The uptake of cochlear implants among adults who could benefit (based on pure-tone audiometry) in developed countries is estimated to be less than 10%. Concerns about potential surgical complications, fear of losing residual hearing, and limited awareness about the benefits of this intervention contribute to the low adoption rate. To enhance quality of life and improve the uptake of cochlear implants, it is essential to have a clear understanding of their benefits.
DESIGN: This umbrella review aims to summarize the major benefits of cochlear implant usage in adults, by synthesizing findings from published review articles. A comprehensive search of databases including MEDLINE, EMBASE, PsycINFO, and Google Scholar, was conducted. The search was limited to English-language review articles published between 1990 and 2022, focusing on cochlear implant outcomes in at least 5 adults (aged ≥18 years). Two independent reviewers screened titles, abstracts, and full-text articles, and conducted a quality assessment using the Joanna Briggs Checklist for Systematic Reviews and Research Syntheses.
RESULTS: Forty-two articles were included in this review. There were 15 systematic reviews with meta-analysis, 25 systematic reviews without meta-analysis, and 2 systematic scoping reviews. All 42 articles underwent quality assessment using the Joanna Briggs Institute Checklist for Systematic Reviews and Research Syntheses, of which 40% (n = 17) satisfied 9 out of 11 quality criteria. This umbrella review shows that cochlear implants are associated with improvements in speech perception and recognition as well as improved quality of life and cognition. These benefits are observed in a significant proportion of adults undergoing the procedure, highlighting its effectiveness as a viable intervention for individuals with severe to profound hearing loss.
CONCLUSIONS: The potential benefits of cochlear implantation appear to outweigh the risks and complications associated with the procedure. It is recommended that adults with severe to profound hearing loss in particular, engage in informed discussions with healthcare professionals to consider cochlear implantation as a viable treatment option.
A dry heat sterilization system having a housing and a number of plenums to guide the flow of hot air. Hot air is forced to flow through the plenums, the intake slide duct and into the bottom of the containers. The hot air will rise and exit from the top of the container through the exhaust slide duct. Furthermore, the external surfaces of the container are also sterilized through the use of semi-pierced duct walls with adjustable diffuser panels. Hot air will re-circulate until it reaches a pre-determined temperature. The container and its contents can be safely handled once the exhaust air blower removes hot air from the system.
The Pericardium 6 and Large Intestine 4 points were slightly touched without pressure to women in the placebo group. Touches were applied to each acupressure point for three minutes similar to the acupressure group, each session of placebo lasted approximately 15 minutes. Similar to the acupressure group, In parallel with the acupressure, the pain score of the women was recorded at the postpartum second hour (Time 1) before intervention and 15 minutes later after intervention (Time 2), and at the fourth hour (Time 3) before intervention and 15 minutes later after intervention (Time 4). Additionally, the analgesic substance and its amount applied during the application were recorded by the researcher.
A 26 residue peptide (Am2766) with the sequence CKQAGESCDIFSQNCCVG­TCAFICIE-NH2 has been isolated and purified from the venom of the molluscivorous snail, Conus amadis, collected of the southeastern coast of India. Chemical modification and mass spectrometric studies establish that Am2766 has three disulfide bridges. C­terminal amidation has been demonstrated by mass measurements on the C-terminal fragments obtained by proteolysis. Sequence alignments establish that Am2766 belongs to the δ-conotoxin family. Am2766 inhibits the decay of the sodium current in brain rNavl .2a voltage-gated Na+ channel, stably expressed in Chinese hamster ovary (CHO) cells. Unlike δ-conotoxins have previously been isolated from molluscivorous snails, Am 2766 inhibits inactivation of mammalian sodium channel.
Data were collected with the Introductory Information Form at the first interview (admission to the postpartum service) with the women in the control group. Post-test data were collected with Primiparous Breastfeeding Motivation Scale and Insufficient Milk Perception Scale at 16-24 hours postpartum.
The second group, the discovery cohort, will be composed of 30 undiagnosed symptomatic patients with clinical suspicion of a genetic disease (both children and adults with onset in infancy or early adulthood) referred to the Clinical Research Center for Rare Diseases "Aldo e Cele Daccò", and for which WES analyses did not reveal any causative genetic alteration. To this end, the investigators plan to recruit around 60 patients, their available parents and/or their available informative relatives who will undergo WES, if not previously done. On the basis of literature and their experience, the investigators expect that WES will be resolutive in 40-50% of cases. Consequently, investigators hypothesize to identify 30 patients with a negative WES who will enter the discovery RNA-Seq cohort.
A method is disclosed for producing coated compressed tablets, using at least one upper punch. The upper punch can be a single punch with a hollow shaft containing a movable rod with a tip that is extended or retracted as the rod moves within the shaft. Alternatively, two solid upper punches are used, one with an extended tip and the other with a retracted tip. An upper punch with an extended tip is designed to produce cup-shaped compacts of excipient and/or polymeric tablet coating material, when inserted into the die. Core material is inserted into each cup. Additional coating material is then placed on top of the cup and core, within the die, and compressed with an upper punch with a retracted tip. The method and device of the present invention enables one to produce tablets from poorly compactable substances.