anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Traditionally, when individuals sustain a musculoskeletal injury and require physical therapy intervention, a referral is obtained from a physician to prescribe therapy. Currently, for non-work related injuries, 48 out of the 50 United States are "direct access physical therapy states" meaning a consumer can be evaluated and treated by a physical therapist directly without physician referral. The number of direct access states is much less for work-related injuries, with only 17 of the 50 United States practice acts permitting direct access, and of these, most insurance companies still require a physician referral for reimbursement. A previous systematic review of the literature on this topic suggests that requiring a referral is associated with more drug prescriptions, more imaging ordered, and higher costs to the patient and health care system with no advantage in health outcomes. However, the cited studies were of low quality (i.e. below Level 1 evidence), so a high quality study with strict experimental controls is still necessary.

This project proposes to conduct a blinded randomized controlled trial to determine if a "direct access physical therapy portal of entry" is more effective than a "physician portal of entry" in decreasing total episode cost and improving outcomes for individuals with a recent onset of musculoskeletal conditions. The project's definition of musculoskeletal pain is any "mechanical" spine or extremity pain from either a work condition (workers compensation) or a non-work related condition. The project investigators plan to recruit potential subjects directly from Temple University employees and supervisors. Subjects who consent to and pass a baseline screening will be randomized to one of two groups: direct access physical therapy management or Employee Health physician management. All PT and physician providers will be "study providers". Subjects randomized to direct access physical therapy will be evaluated and treated by a physical therapist. If the presentation requires further work up, the therapist will refer the patient for imaging or specialty consult. Subjects randomized to the Employee Health physician will receive a similar evaluation ordering relevant work up, and if appropriate, the physician will refer the patient to a physical therapist. Health outcomes for the two groups will be compared with a mixed-model repeated measures analysis at 1 month after enrollment. Total episode cost and medical utilization will be compared at one year after enrollment.

If this direct access "Temple University model" is feasible and effective for managing compensated and non-compensated musculoskeletal conditions, it could serve as a paradigm for other universities to implement across the United States. Furthermore, this study would be the first data set in the literature that studied a physical therapy direct access model for evaluation and treatment of employees with "workers-compensation" conditions in the United States.
Free-hand placement of ventricular catheters (VC) is reported to be inaccurate in 10-40%. Furthermore, there is evidence that the quality of VC positioning is correlating with the risk for proximal shunt obstruction. Ultrasound or neuronavigation are used in order to improve to placement. However, they are associated with significant technical efforts and increased time.

In this study a simple instrument assisted by a smart phone application software is used in order to achieve precise placement of ventricular catheters. The results are compared with the standard free-hand procedure. Patients requiring a ventricular catheter are randomized to one of the two treatments. The primary outcome parameter is a qualitative and quantitative assessment of the position of the ventricular catheter on a post-operative image. The evaluation of the primary criteria is performed by a radiologist blinded to the randomization arm.
A computing system is provided in which sparse vectors is obtained. Each vector represents a single entity, and has at least ten thousand elements each of which represents an entity feature. Less than ten percent of the elements in each vector is present in the input data. The vectors are applied to a plurality of denoising autoencoders. Each respective autoencoder, other than the final autoencoder, feeds intermediate values as a function of (i) a weight coefficient matrix and bias vector associated with the respective autoencoder and (ii) input values received by the autoencoder, into another autoencoder. The final autoencoder outputs a dense vector, consisting of less than 1000 elements, for each sparse vector thereby forming a plurality of dense vectors. A post processor engine is trained on the plurality of dense vectors causing the engine to predict a future change in a value for a feature for a test entity.
Since a previous systematic review published in 2016, there have been further studies investigating the association of changes in cognitive function following bariatric surgery. All studies since the original review that reported at least one element of cognitive function before and after bariatric surgery were eligible. A total of 137 additional studies were identified; 13 were included in addition to the 18 studies previously. Almost all studies reported improvements in at least one domain. Most revealed improvements were limited to a few domains and were not universal. Further findings investigated cognitive function improvement in relation to procedure choice, and mental health or quality of life post-surgery. Further high-powered studies are still necessary, but these findings support the impact of bariatric surgery on cognitive function in obesity.
A patient with a tumor lesion of the chest wall undergoes СT scan with a step width of less than 1 mm, then engineers design an individual model to replace the defect. Using a 3D printer, a model is made based on the patient's anthropometric data.
Participants in the F/TDF group will transition to get LEN and participants in the LEN group will continue to get LEN. All participants will get SC LEN on Day 1 and week 26 of the OLE phase.
This study is a randomized controlled trial comparing High Frequency nasal CPAP versus standard nasal CPAP. The patient population includes preterm newborns who require respiratory support but do not need to be initially intubated and preterm or term infants who are being extubated and will require support for the continued lung disease. After obtaining parental consent the patient will be randomized to one of the two treatments. Patients will be followed for requirement of level of oxygen and blood gases looking at acidity (pH) and PaCO2 and Bicarbonate(HCO3). A respiratory index score will be measured. Attending physician will determine the need for the patient to be intubated or reintubated depending on the patient selected. Additionally, frequency, duration and severity of Apnea, Bradycardia and Desaturation events will be recorded. Also safety issues to include pulmonary airleak, nasal injury, facial edema and scalp edema due to straps holding the device in place will be recorded. Also gaseous distension of the stomach and intestines will be assessed and compared between treatment arms. This study is not powered to look at long term outcomes.
PURPOSE:An antitumor agent comprising protein having activity like lectin as a main component. CONSTITUTION:An antitumor agent comprising a main component of protein having 188,000mol.wt. by gel filtration method, properties wherein it is divided into a subunit of 4mol having 32,000mol.wt. by SDS-gel electrophoresis and a subunit of two molecules having 30,000mol.wt., characteristics wherein it occurs in the humor of a representative of a larva of Sarcophaga peregrina when it is injured, occurring in the humor of its chrysalis at the early stage of pupation, having activity like lectin. The protein is observed to induce production of interferon of human leukocyte. Its dosage form is properly injection for intramuscular injection or intravenous injection, etc. or suppository to be used with an absorption promotor, etc. A dose is properly 3,000-5,000mug/kg/day.
In each treatment session, the patients will receive EA treatment. The selected acupoints for needling will be BL2, GB1, GB14, ST2, SI18, ST6, ST4, ST7, SJ17, EX-HN16, EX-HN5, on affected side, and LI4, bilaterally. After the de-qi sensation is achieved, electrical stimulator will be connected to BL2-GB1, and ST4-ST6, and 2Hz continuous wave will be used for 20 min.
BACKGROUND: Coronary computed tomography angiography (CCTA) is used to evaluate components of atherosclerosis. Either adaptive or diverse, fixed Hounsfield Units (HU) are used to define components such as low attenuation (LAP), mixed (MP) and calcified plaque (CP). Comparisons of different platforms and different thresholding approaches have not been extensively evaluated. We compare two fixed threshold options to an adaptive threshold option within a specific platform and to fixed threshold options measured with another platform.
METHODS: Coronary segments (n ​= ​24) of good image quality, with well-defined boundaries and representing a broad range of atheroma were analyzed for LAP, MP and CP. Thresholds for LAP vs MP and MP vs CP were either Fixed30/350, Fixed75/350 or based on an automatically determined Adaptive option. Pearson correlation and Bland-Altman analyses were undertaken.
RESULTS: Within a single platform, measures were highly correlated irrespective of use of Adaptive or Fixed30/350 and Fixed75/350 thresholds (R ​≥ ​0.819, p ​< ​0.000001). The correlation slope for measures of LAP progressively diminished comparing the Adaptive versus Fixed30/350 and the Fixed75/350 versus the Fixed30/350 approaches but bias was small. Between-platform comparisons yielded less optimal results, particularly with respect to measures of LAP and with one platform yielding both very small LAP volumes and very small ranges of volumes.
CONCLUSION: Measures of plaque components are highly correlated irrespective of use of Adaptive or Fixed threshold approaches within a given platform. But measures are more affected by the specific proprietary algorithms employed than by specific thresholding options, especially for LAP.
PURPOSE: A pharmaceutical composition containing extract and fraction of an aerial part of Oryza sativa L. and flavonolignan compounds isolated from the same is provided to suppress NO generation and to reduce side effects. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory diseases contains extract of an aerial part of Oryza sativa L. as an active ingredient. The extract is prepared using 80% methanol solution. The pharmaceutical composition contains a fraction of an aerial part of Oryza sativa L. as an active ingredient. The fraction is prepared by extracting the extract using n-hexane and H_2O, extracting a H_2O layer using ethyl acetate, and extracting H_2O by n-butanol. The pharmaceutical composition contains flavonolignan compounds or pharmaceutically acceptable salt thereof as an active ingredient.
The invention discloses a preparation method of probiotics type hydrolyzed whey protein for promoting calcium absorption, and belongs to the fields of natural product processing and nutrition and health of special people. The whey protein is prepared by enzymolysis of neutral protease and flavourzyme, chelation of the whey protein with calcium chloride and embedding of probiotics. Not only effectively improves the poor heat stability and difficult absorption of whey protein, but also overcomes the defect of the traditional calcium supplement. The addition of flavourzyme is effective in improving the bitter taste of hydrolysed whey protein. The addition of probiotics enables the product to achieve the nutrition and health effects of 1+1+1>3, the intestinal absorption capacity of the old is obviously improved, and physiological diseases are effectively prevented. The bioavailability of the whey protein can be obviously improved when the product is applied to the fields of functional foods, medicines, health products and the like, and the technical bottleneck of low survival rate of probiotics is avoided, so that the effect maximization can be further realized. The invention further verifies the health efficacy through cell experiments and animal experiments.
The intensive lifestyle modification intervention will consist of caloric restriction (consumption of approximately 1200-1500 kcal/d), use of an over-the-counter weight loss medication (Alli, which is brand name Orlistat, a gastric lipase inhibitor that limits gut fat absorption), and moderate physical activity (goal of reaching 10,000 steps a day). The pretreatment intervention will last 16 weeks and is designed to promote a weight loss of approximately 7% of total body weight.
The invention relates to a method for preparing kidney tonifying and desire lessening capsules, which aims to tonify the kidney by wolfberry with an effect of tonifying the kidney and lessening desires by traditional Chinese medicine phellodendron amurense with an effect of inhibiting testicles from generating male sex hormone. In a specific operating method, the kidney tonifying and desire lessening capsules have a formula of the wolfberry to the phellodendron amurense of 1:1; and the unit is kilogram. The specific operating method comprises the following steps: respectively placing the wolfberry and the phellodendron amurense into an oven; heating to the temperature of 50 to 60 DEG C; when sufficiently drying the phellodendron amurense and drying the wolfberry to the degree that the wolfberry is hardened and can be broken with a small force, discharging the wolfberry and the phellodendron amurense out of the oven; mixing the wolfberry and the phellodendron amurense according to the ratio of 1:1; grinding and sieving by 60 to 100 meshes; and packaging the obtained products into capsules. The kidney tonifying and desire lessening capsules are take in a manner that 4 to 6 capsules are taken each time, taken for three times each day and continuously taken for three days. Therefore, a man can be enabled not to desire the sex life in five to six days; and after having sex for once to twice, the man takes the kidney tonifying and desire lessening capsules for 3 days again. Therefore, the man only has sex for about four to six times each month. Due to the proper reduction of the times of the sex life, both the male and the female are energetic and the kidney tonifying and desire lessening capsules are beneficial to work. Meanwhile, the quality of sex life each time is greatly improved.
PURPOSE: Both obstructive sleep apnea (OSA) and the common cold are disorders of the upper respiratory tract, and may be associated. However, studies on the association between OSA and upper respiratory tract infections (URTI) in children are scarce. The aim of this study was to investigate possible associations between snoring, the severity of OSA, and URTI in elementary school children.
METHODS: This was a cross-sectional study in a community cohort of elementary school children (first and second graders) in Japan. Information on sleep habits, history of URTI, and OSA risk was obtained from a parental questionnaire. Children underwent overnight tracheal sound recordings from which apnea-hypopnea index was estimated. Multivariable logistic analysis was employed to define the association between snoring, OSA, and URTI ≥ 3 episodes over six months.
RESULTS: Of the 922 potential enrollees, 653 children and their parents (71%) agreed to participate in the study. Multivariable-adjusted ORs for URTI were 1.73 (95%CI: 1.16 to 2.59) in children who snored 1 to 4 nights per week and 2.82 (95%CI: 1.26 to 6.28) in snoring ≥ 5 nights per week compared with never snoring (reference). Likewise, subjectively reported louder snoring, as well as objectively defined louder sound levels, were significantly associated with URTI. In addition, OR for URTI in children with an estimated apnea-hypopnea index ≥ 2.0 events/hour was 2.65 (95%CI: 1.32 to 5.31) compared to children with apnea-hypopnea index less than 1.0 events/hour (reference).
CONCLUSIONS: Snoring and severity of OSA as measured by nocturnal tracheal sound recordings were associated with increased susceptibility to URTI in elementary school children.
PURPOSE:To satisfy the condition of the specified and invariable ease of biting and ease of feeding as a food lump and to allow natural mastication at the time of measurement by incorporating functional fine particles for evaluating a mastication function to be compressed by a masticatory pressure into the artificial food lump. CONSTITUTION:Microcapsules, for example, spherical microcapsules made of polycarbonate (hereafter described as capsule) are more preferable as the functional fine particles to be masticated. The capsules have preferably the characteristic that the capsules are crushed flat from the spherical shape without being broken by the mastication and that the capsules maintain the flat shape thereafter. After the capsules are produced by an underwater drying method, the particle sizes thereof are uniformed by using stainless steel sieves of 177mum and 210mum openings specified in JIS. The chewing gum-like artificial food lump is produced by incorporating the capsule groups into adhesive polyisobutyrene. The artificial food lump is constituted of the two components; the capsule groups and the chewing gum. The preferable particle sizes of the capsules distribute in a 193.5mum+ or -8.5% range. The adequate number of the particles to be incorporated into the artificial food lump is about 8.10X10<4> (pieces).
Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease worldwide, leading to significant morbidity, mortality, and high treatment costs. In 2020, the global prevalence of COPD was estimated to be 10.6%, affecting around 480 million people. The diagnosis of COPD in suspected patients is typically confirmed through routine spirometry, a simple noninvasive test that assesses the degree of airway obstruction. However, research has revealed that extensive small airway disease exists in COPD before it can be detected using traditional spirometric measures, such as forced expiratory volume in the first second (FEV1) and the ratio of FEV1 to forced expiratory capacity (FEV1/FVC). Efforts are underway to find new parameters to improve early detection of airway obstruction in patients with COPD. The expiratory time constant (RCexp) is a promising variable studied in critical care medicine and may also prove useful in pulmonology. Data from ventilated COPD patients demonstrate that prolonged RCexp was present in all patients with COPD. The FEV1/FVC ratio is currently the gold standard for diagnosing COPD, but it only yields a single calculated value. In contrast, RCexp may offer more precision as it reflects exhalation dynamics at multiple time points during exhalation. If there is a prolongation of subsequent RCexp towards the end of exhalation, it could indicate the presence of obstruction. We hypothesize that RCexp during tidal and forced exhalation implemented to the routine spirometer may detect airway obstruction earlier than conventional spirometric indices such as FEV1 and FEV1/FVC.
Although it is known that the availability of visual feedback modulates grasping kinematics, it is unclear whether this extends to both the early and late stages of the movement. We tackled this issue by exposing participants to the Uznadze illusion (a medium stimulus appears larger or smaller after exposure to smaller or larger inducers). After seeing smaller or larger discs, participants grasped a medium disc with (closed-loop [CL]) or without (open-loop [OL]) visual feedback. Our main aim was to assess whether the time course of the illusion from the movement onset up to the grasp differed between OL and CL. Moreover, we compared OL and CL illusory effects on maximum grip aperture (MGA) and tested whether preparation time, movement time, and time to MGA predicted illusion magnitude. Results revealed that CL illusory effects decreased over movement time, whereas OL ones remained constant. At the time of MGA, OL, and CL effects were, however, of similar size. Although OL grasps were longer to prepare and showed earlier and larger MGAs, such differences had little impact on modulating the illusion. These results suggest that the early stage of grasping is sensitive to the Uznadze illusion both under CL and OL conditions, whereas the late phase is sensitive to it only under OL conditions. We discuss these findings within the framework of theoretical models on the functional properties of the dorsal stream for visually guided actions.
Currently，follow-up study is limited on glucose intolerance and life quality assessment. However, it has been shown that AP is associated to some extent with other diseases such as chronic pancreatitis, pancreatic cancer, pancreatogenic portal hypertension and autoimmune pancreatitis; In addition, for patients who have severe lung injury following AP, especially with PaO2/FiO2\<200 during ICU stay, the long term prognosis remains unclear. Thus, a large sample follow-up study is essential for elucidating the possible long-term complications.

Prior to follow up study, the investigators performed baseline analysis of AP patient data from the database of the First Affiliated Hospital of Nanchang University. It is estimated that 1300 patients will be interviewed over telephone and 600 patients in the outpatient department. The content of the follow-up includes: questionnaire (the MOS\[medical outcome study\] item short from health survey, SF\[short form\]-36) ; lab testing(complete blood count, blood chemistry such as liver and kidney function, C-reaction protein(CRP), AMY, fasting blood-glucose，1 and 2 hour postprandial blood glucose,C-peptide, blood lipids, FE-1) and CT scan. For patients who have severe lung injuries during ICU stay, pulmonary function test, Blood gas analysis and chest CT will be performed. After screening, the patients with chronic pancreatitis(CP), pancreatic cancer(PC), post Pancreatogenic portal hypertension（PPH） or autoimmune pancreatitis(AIP）will be hospitalized for further therapy.
Subjects will be started with a single pill containing 30mg of LDX or comparable placebo, depending on the treatment assignment. At the week 2 visit, the dose will be increased to 50 mg (or comparable placebo) if the patient exhibits no significant adverse effects as judged by the Investigator. At the week 4 visit, the dose will be increased to 70 mg (or comparable placebo) if the patient exhibits no significant adverse effects as judged by the investigator.
The intervention is a behavioral intervention, which consists of giving patients and caregivers iPods to listen to music for up to 60 minutes while the patient is receiving a chemo infusion. Participants and caregivers in the control condition complete a presurvey and post survey but do not listen to music during infusion session .