anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obesity has reached epidemic proportions in the USA and Europe, and is increasing world-wide. Morbid obesity (BMI\>40kg/m2) is usually resistant to medical and dietary therapy while surgical treatment results in a permanent loss of most of the excess weight. The most popular technique today is the Roux-en-Y gastric bypass procedure which results in a weight loss of approximately 95 lbs per year or a 2/3 loss of the excess weight in 2 years (7-9). Weight loss occurs for 2 reasons: first the volume of the stomach is reduced, and second, the duodenum and first part of the jejunum is bypassed resulting in malabsorption. Although most patients tolerate the procedure well with a leveling off of weight loss close to the ideal body weight, a subpopulation of patients continue to lose weight, becoming progressively more malnourished, necessitating reversal of the surgery. To date, no studies have investigated what happens to pancreatic function in obese patients following bypass surgery, but from an understanding of the physiology of pancreatic stimulation, it is likely that the pancreas atrophies because the intestinal phase of pancreatic stimulation is bypassed and the inhibitory ileal brake is perpetually stimulated. In the following study we plan to investigate whether patients with excessive weight loss after bypass surgery develop malabsorption not only due to bypass of the upper GI tract but also because of impaired pancreatic enzyme secretion resulting from chronic activation of the ileal brake mechanism. Up to 20 post-bariatric surgery (Roux-en-Y) patients with excessive and continued weight loss will be screened for fat absorption and loss of pancreatic secretion. Those with loss of \>20% fat absorption will then be treated at home with pancreatic enzyme supplements for a 3 month period to assess weight stabilization or gain. After 3 months, fat absorption and the pancreatic stimulation test will be repeated while patients are on enzyme supplementation to determine whether fat digestion and absorption has improved from baseline.
Aortic dissection (AD) is the most catastrophic vascular disease with a high mortality rate. Trimethylamine N-oxide (TMAO), a gut microbial metabolite, has been implicated in the pathogenesis of cardiovascular diseases. However, the role of TMAO in AD and the underlying mechanisms remain unclear. This study aimed to explore the effects of TMAO on AD. Plasma and fecal samples from patients with AD and healthy individuals were collected to analyze TMAO levels and gut microbial species, respectively. The plasma levels of TMAO were significantly higher in 253 AD patients compared with those in 98 healthy subjects (3.47, interquartile range (IQR): 2.33 to 5.18 μM vs. 1.85, IQR: 1.40 to 3.35 μM; p < 0.001). High plasma TMAO levels were positively associated with AD severity. An increase in the relative abundance of TMA-producing genera in patients with AD was revealed using 16S rRNA sequencing. In the angiotensin II or β-aminopropionitrile-induced rodent model of AD, mice fed a TMAO-supplemented diet were more likely to develop AD compared to mice fed a normal diet. Conversely, TMAO depletion mitigated AD formation in the BAPN model. RNA sequencing of aortic endothelial cells isolated from mice administered TMAO revealed significant upregulation of genes involved in inflammatory pathways. The in vitro experiments verified that TMAO promotes endothelial dysfunction and activates nuclear factor (NF)-κB signaling. The in vivo BAPN-induced AD model confirmed that TMAO increased aortic inflammation. Our study demonstrates that the gut microbial metabolite TMAO aggravates the development of AD at least in part by inducing endothelial dysfunction and inflammation. This study provides new insights into the etiology of AD and ideas for its management.
To determine the disease prevalence rate and clinical characteristics of Vogt-Koyanagi-Harada (VKH) disease among new patients before and after the declaration of a state of emergency (April 7, 2020) in Japan. New patients and patients with newly diagnosed VKH disease were categorized into "Before" and "After" groups based on the initial visit. The prevalence rate, sex ratio, and age of patients newly diagnosed with VKH were compared between the groups. Best-corrected visual acuity (BCVA) and recurrence rates were compared among 59 patients observed for > 12 months after receiving pulse steroid therapy. For reference, we also examined the prevalence rate of patients newly diagnosed with acute angle closure (AAC) in the Before and After groups. The prevalence rates of VKH disease among newly diagnosed patients (P < 0.05) or patients with AAC (P < 0.001) were significantly higher in the After group. No significant differences in sex ratio or age of VKH disease were observed in both groups. BCVA and recurrence rates showed no significant differences. The COVID-19 pandemic increased the prevalence of VKH disease among new patients compared with that of AAC. However, the clinical features of VKH disease were unlikely affected by the COVID-19 pandemic.
The maxillary arch will be levelled and aligned. (250-300) g force will be applied on each side using two NiTi springs attached between the mini-implants and the soldered hooks in a direction approximately parallel to the occlusal plane for conducting an en-masse retraction.
This study aimed to explore the relationship between self-reported sensory decline, including poor hearing and vision, and cognitive frailty in older persons. This cross-sectional study analyzed data from the 2020 National Survey of Living Conditions and Welfare Needs of Older Koreans. Binomial logistic regression analysis was performed to analyze the relationship between self-reported sensory decline and cognitive frailty. Of 9,692 participants, 39.8 % experienced sensory decline. The prevalence of cognitive frailty was 15.7 % among participants with poor hearing, 6.9 % among those with poor vision, and 17.9 % among those with combined poor hearing and vision. In our model, adjusted for sociodemographic and health-related variables, the cognitive frailty was significantly associated with poor hearing alone and combined poor hearing and vision. The findings suggest that healthcare professionals should prioritize their attention to the risk of cognitive frailty in older adults experiencing poor hearing alone and combined with poor vision.
PURPOSE:A cosmetic having smoothness, excellent fluidity, improved safety to microorganisms, molding workability, foam stability, etc., containing carboxymethyl cellulose having high substitution degree. CONSTITUTION:A cosmetic containing a carboxymethyl cellulose salt (CMC having high substitution degree) having 1.6-3.0 (preferably >=2.0) mols of substitution group per glucose group. The CMC having high substitution degree has a very small amount of microgel, and when it is used in an emulsified, suspended, or dispersed system, a product having extreme smoothness and improved safety to microorganisms can be obtained. When it is used in a pack agent, a film of coating with clean surface can be prepared. A water-soluble salt of Na, K, Li, Ca, quaternary ammonium, etc. is usable as the CMC having high substitution degree.
A 71-year-old man with hypertension and diabetes mellitus presented to our hospital because he felt lightheaded. Diffusion-weighted images (DWI) on brain MRI showed high signal lesions in the left cerebellar hemisphere and the right pons. The diagnosis of cerebellar infarction was made, but he refused treatment. One month later, he came to our hospital because his body leaned to the left. Neurological examination revealed dysarthria and cerebellar truncal ataxia. An electrocardiogram showed atrial fibrillation. DWI on brain MRI showed high signal lesions in the bilateral cerebellar hemispheres and middle cerebellar peduncles (MCP). Dabigatran 300 ‍mg/day was administered for cardiogenic cerebral embolism. On the 12th day of onset, he was transferred to a rehabilitation hospital. At 72 years old, T2*-weighted images on brain MRI showed hot cross bun sign (HCBs) in the pons. We considered that HCBs were caused by antegrade or retrograde degeneration (or both) of pontine infarcts and bilateral MCP infarcts in the pontine cerebellar tract. It seemed preferable to use T2*-weighted images or proton density-weighted images rather than T2-weighted images to detect HCBs. When HCBs is detected, it should be noted that HCBs can be caused by bilateral MCP infarcts in addition to multiple system atrophy.
BACKGROUND: Adjunctive screw fixation has been shown to be reliable in achieving acetabular component stability in revision total hip arthroplasty (THA). The purpose of this study was to assess the effect of inferior screw placement on acetabular component failure following revision THA. We hypothesized that inferior screw fixation would decrease acetabular failure rates.
METHODS: We reviewed 250 patients who had Paprosky Type II or III defects who underwent acetabular revision between 2001 and 2021 across three institutions. Demographic factors, the number of screws, location of screw placement (superior versus inferior), use of augments and/or cup-cage constructs, Paprosky classification, and presence of discontinuity were documented. Multivariate regression was performed to identify the independent effect of inferior screw fixation on the primary outcome of aseptic rerevision of the acetabular component.
RESULTS: At a mean follow-up of 53.4 months (range, 12 to 261), 16 patients (6.4%) required re-revision for acetabular loosening. There were 140 patients (56.0%) who had inferior screw fixation, all of whom did not have neurovascular complications during screw placement. Patients who had inferior screws had a lower rate of acetabular rerevision than those who only had superior screw fixation (2.1 versus 11.8%, P = .0030). Multivariate regression demonstrates that inferior screw fixation decreased the likelihood of rerevision for acetabular loosening when compared to superior screw fixation alone (odds ratio: 0.1, confidence interval: 0.03 to 0.5; P = .0071). No other risk factors were identified.
CONCLUSIONS: Inferior screw fixation is a safe and reliable technique to reduce acetabular component failure following revision THA in cases of severe acetabular bone loss.
Subjects with NICM will undergo mapping and substrate-based ablation for the treatment of ventricular tachycardia with the investigational FlexAbility SE Catheter. The Ampere Generator, Cool Point Irrigation Pump and the EnSite Precision Cardiac Mapping System or EnSite X EP System will be used in conjunction with the FlexAbility SE catheter in the ablation procedure. Subjects will be followed for 12 months post-procedure.
The invention discloses a liquid medicine formula for treating various osteoproliferation and a preparation method thereof. The liquid medicine formula is researched and improved based on the secret recipe handed down in the family, and is used for treating various osteoproliferation and bone spur. Patients of various osteoproliferation worry much about whether the western medicine or the traditional Chinese medicine has toxicity more or less, but the liquid medicine formula provided by the invention eliminates the worry of patients, and osteoproliferation can be rapidly cured in a short time when the liquid medicine formula is applied at the affected part, so that the liquid medicine formula brings great convenience to patients in work and life. The liquid medicine formula has no side effects to bodies of patients, and has obvious curative effect. If a patient with common osteoproliferation uses the liquid medicine for about one month, the osteoproliferation or bone spur can be cured; for patients with serious osteoproliferation, the osteoproliferation or bone spur can be cured in about two or three month or the pain can be greatly relieved. The obvious effective rate is above 85%, and the cure rate is over 70%, so that the liquid medicine formula is convenient and simple to use.
We present a case of a man in his 30s presenting with ST-segment elevation myocardial infarction and eosinophilia. The patient underwent thrombus aspiration and initially echocardiographic evaluation was normal. The patient was discharged after 2 days, but was hospitalised again after 6 days. Echocardiographic evaluation now revealed a thrombus formation on the aortic valve. Laboratory data revealed increasing eosinophilia, and treatment with high-dosage corticosteroids and hydroxyurea was initiated as eosinophilic disease with organ manifestations could not be precluded. Eosinophils normalised and the patient was discharged again. The combination of hypereosinophilia and absence of infection, rheumatological disorders and malignancy, led to reactive or idiopathic hypereosinophilic syndrome being the most plausible diagnoses. The patient was closely monitored in the cardiology and haematology outpatient clinics. Echocardiographic evaluation, performed 6 weeks after the patient was discharged, showed significant regression in the size of the thrombus mass.
The invention relates to an oral drug for treating diabetes, in order to solve the problem that the prior drugs for treating diabetes have not obvious effects and have side effects. The oral drug is prepared from the raw materials with the following portions by weight: 20-80 portions of birch antler, 20-80 portions of shell-broken lingzhi spore powder. The lingzhi spore powder is laser shell-broken spore powder, and the birch antler is crushed birch antler powder. The birch antler powder is 250 meshes of birch antler powder. The raw materials are prepared into medicinal granules, capsule, troche, decoction, pill, powder and mixed powder according to the normal methods. The oral drug for treating diabetes has the advantages of obvious and fast healing efficacy without side effect. The oral drug also can be used for treating heart disease, high blood pressure, hepatitis and liver ascites, and has the advantage of obvious heating efficacy.
INTRODUCTION: Infectious diseases can spread rapidly in the globalized world, and the complex intersection of individual, social, economic, and cultural factors make it difficult to identify vulnerabilities in the face of pandemics.
METHODS: Therefore, this study aimed to identify vulnerability factors to infection and worse outcomes associated with COVID-19. This is a scoping review study of six databases that selected publications between 2019 and 2023, focusing on individual, social, and programmatic dimensions of vulnerability. The results were recorded in a spreadsheet and analyzed, considering the interrelationships among these dimensions.
RESULTS: A total of 45 articles were included in the review. Content analysis was conducted using the theoretical framework of health vulnerability, which divides vulnerability into individual, social, and programmatic dimensions. Race/ethnicity, homelessness, incarceration, socioeconomic level, food insecurity, and remote areas were classified as social dimensions. On the other hand, cancer, cardiovascular disease, HIV/AIDS, alcoholism, advanced age, obesity, mental disorders, diabetes, kidney disease, and pregnancy were classified as individual dimensions. None of the publications found explicitly mentioned programmatic vulnerabilities.
DISCUSSION: The research found that social vulnerabilities reinforce individual vulnerabilities, creating a vicious cycle. In addition, programmatic vulnerabilities reinforce this relationship. This study emphasizes that public policies should address these different dimensions of vulnerability. It suggests that this information should be incorporated into health surveillance and future decision-making to face new pandemics.
SYSTEMATIC REVIEW REGISTRATION: https://archive.org/details/osf-registrations-wgfmj-v1.
The invention relates to an external application traditional Chinese medicine for treating traumatic synovitis. The external application traditional Chinese medicine consists of the following raw materials in parts by weight: 10-30 parts of cotton rose hibiscus leaf, 10-30 parts of amur corktree bark, 15-30 parts of philippine violet herb, 10-20 parts of dandelion, 10-15 parts of rhubarb, 10-15 parts of szechuan lovage rhizome, 10-20 parts of medicinal cyathula root, 10-20 parts of szechuan papaya, 3-5 parts of pseudo-ginseng root, 10-15 parts of safflower, 2-4 parts of dragon's blood, 15-30 parts of Chinese angelica, 10-15 parts of common clubmoss herb and 3-5 parts of catechu. The external application traditional Chinese medicine is prepared by mixing the raw materials proportionally, and grinding into medicinal powder. The external application traditional Chinese medicine is applied by the following steps of: preparing an appropriate amount of medicinal powder according to a wound position; adding a small amount of honey; preparing into paste with boiled water; wrapping with gauze till the thickness is about 3-5 millimeters; and coating an external application wound with elastic bondage, wherein application is performed once every four hours for 20 hours every time, and a treatment course lasts for seven days. The external application traditional Chinese medicine can be used for effectively treating traumatic synovitis. The effective rate is 100 percent, and the curative rate is 81 percent.
Clindacin Foam can cause irritation. Concomitant topical acne therapy should be used with caution since a possible cumulative irritancy effect may occur, especially with the use of peeling, desquamating, or abrasive agents. If irritation or dermatitis occurs, clindamycin should be discontinued.

Avoid contact of Clindacin Foam with eyes, mouth, lips, other mucous membranes or areas of broken skin. If contact occurs, rinse thoroughly with water.

Clindacin Foam should be prescribed with caution in atopic individuals.
The invention discloses traditional Chinese medicine radix gentianae and sophora flavescens pills for treatment of cholecystitis, and the pills are mainly used to solve problems of existing western medicine for treatment of cholecystitis that: curative effect is poor and side-effects also exist. The pills are produced by following steps: taking 120g of radix gentianae, 120g of sophora flavescens, 120g of rheum officinale, 120g of radix curcumae and 120g of desmodium grinding; grinding the five ingredients into fine powders together; taking 10 bitter pig gallbladders; and then the powders are made into pills with pig bile as an adhesive, and the pills are as large as phoenix tree seeds. Dosage and administration are that: 9 to 12g each time, and 3 times a day. In one treatment course, all the ingredients with the total amount mentioned above are taken. Advantages of the pills are that: effective rate for treatment of cholecystitis is 95% or more, and cure rate is 80% or more. The pills have no toxic or side effect.
In the intervention practices the SDM process is used. In the SDM proces the patient and GP use a decision aid to discuss the pros and cons of two evidence based treatment possibilities, according to the Dutch College of General Practitioners (NHG) versus the ADDITION guideline, and the patients' preferences for either of these treatments. Together they choose one of these treatments, and set the five treatment targets (blood pressure, cholesterol, HbA1c, smoking status and weight) in order of priority. Subsequent treatment will take place according to the priorities of these OPTIMAL treatment targets. The priorities will be evaluated every 12 months.
<P>PROBLEM TO BE SOLVED: To provide a solid agent A for dialysis which contains various electrolytic components, pH adjusters and/or glucose used for hemodialysis treatment of renal failure patients which has high cleanliness, high dissolution rate and good workability preventing generation of powder (dust).  <P>SOLUTION: The solid agent A for dialysis is used for preparing a bicarbonate dialysis fluid. When particle size distribution of granulated materials contained in the agent A is measured by screening method, a fraction retainable on a 850 μm mesh screen is ≤5% and a fraction retainable on a 355 μm mesh screen but passing through 600 μm mesh screen is ≥50%. With such a particle size distribution, dissolution rate of the agent A is improved and generation of powder is prevented. In addition, by using electrolytic components having silicon content of ≤5 ppb, the cleanliness of perfusion fluid for dialysis is improved.  <P>COPYRIGHT: (C)2007,JPO&INPIT
INTRODUCTION: Systemic Lupus Erythematosus (SLE) is a multi-dimensional autoimmune disease involving numerous tissues throughout the body. The chromatin accessibility landscapes in immune cells play a pivotal role in governing their activation, function, and differentiation. Aberrant modulation of chromatin accessibility in immune cells is intimately associated with the onset and progression of SLE.
AREAS COVERED: In this review, we described the chromatin accessibility landscapes in immune cells, summarized the recent evidence of chromatin accessibility related to the pathogenesis of SLE, and discussed the potential of chromatin accessibility as a valuable option to identify novel therapeutic targets for this disease.
EXPERT OPINION: Dynamic changes in chromatin accessibility are intimately related to the pathogenesis of SLE and have emerged as a new direction for exploring its epigenetic mechanisms. The differently accessible chromatin regions in immune cells often contain binding sites for transcription factors (TFs) and cis-regulatory elements such as enhancers and promoters, which may be potential therapeutic targets for SLE. Larger scale cohort studies and integrating epigenomic, transcriptomic, and metabolomic data can provide deeper insights into SLE chromatin biology in the future.
Patients will receive intralesional infiltration of (SSG) at a dose of 50 mg/0.5 ml (0.2-0.4ml) maximum dose per session 1-3 ml. Sessions will be held once weekly for a maximum of 6 weeks.
PURPOSE:To provide the titled carcinostatic agent effective to inhibit spermidine synthetase, having excellent carcinostatic and antimetastatic activities and low toxicity, and containing N-sulfododecahydrodiphenylamide derivative or its acid addition salt as an active component. CONSTITUTION:The objective metastasis-suppressing carcinostatic agent contains N-sulfododecahydrodiphenylamine of e.g. formula I , its derivative, the compound of e.g. formula II obtained by adding an addition group to the N atom of dodecahydrodiphenylamine through covalent bond, sulfonyldiamine-N,N,N'N'- tetracyclohexane of e.g. formula III, or acid addition salt of the above compounds. The above active component inhibits the synthesis of spermidine promoted in cancer cells, and at the same time, substantially suppresses the growth, metastasis and infiltration of cancer. It has little side effect even at a high dose. Dose: 1-200mg/kg daily.