anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cardiomegaly is among the disorders categorized by a structural enlargement of the heart by any of the situations including pregnancy, resulting in damage to heart muscles and causing trouble in normal heart functioning. Cardiomegaly can be defined in terms of dilatation with an enlarged heart and decreased left or biventricular contraction. The genetic origin of cardiomegaly is becoming more evident due to extensive genomic research opening up new avenues to ensure the use of precision medicine. Cardiomegaly is usually assessed by using an array of radiological modalities, including computed tomography (CT) scans, chest X-rays, and MRIs. These imaging techniques have provided an important opportunity for the physiology and anatomy of the heart. This review aims to highlight the complexity of cardiomegaly, highlighting the contribution of both ecological and genetic variables to its progression. Moreover, we further highlight the worth of precise clinical diagnosis, which comprises blood biomarkers and electrocardiograms (EKG ECG), demonstrating the significance of distinguishing between numerous basic causes. Finally, the analysis highlights the extensive variation of treatment lines, such as lifestyle modifications, prescription drugs, surgery, and implantable devices, although highlighting the critical need for individualized and personalized care.
Methemoglobinemia has been reported in patients receiving other organic nitrates, and it probably could also occur as a side effect of isosorbide mononitrate. Certainly nitrate ions liberated during metabolism of isosorbide mononitrate can oxidize hemoglobin into methemoglobin. Even in patients totally without cytochrome b5 reductase activity, however, and even assuming that the nitrate moiety of isosorbide mononitrate is quantitatively applied to oxidation of hemoglobin, about 2 mg/kg of isosorbide mononitrate should be required before any of these patients manifest clinically significant (≥10%) methemoglobinemia. In patients with normal reductase function, significant production of methemoglobin should require even larger doses of isosorbide mononitrate. In one study in which 36 patients received 2-4 weeks of continuous nitroglycerin therapy at 3.1 to 4.4 mg/hr (equivalent, in total administered dose of nitrate ions, to 7.8 to 11.1 mg of isosorbide mononitrate per hour), the average methemoglobin level measured was 0.2%; this was comparable to that observed in parallel patients who received placebo.

Notwithstanding these observations, there are case reports of significant methemoglobinemia in association with moderate overdoses of organic nitrates. None of the affected patients had been thought to be unusually susceptible.

Methemoglobin levels are available from most clinical laboratories. The diagnosis should be suspected in patients who exhibit signs of impaired oxygen delivery despite adequate cardiac output and adequate arterial pO2. Classically, methemoglobinemic blood is described as chocolate brown without color change on exposure to air. When methemoglobinemia is diagnosed, the treatment of choice is methylene blue, 1 to 2 mg/kg intravenously.
The invention discloses a radiographic image capture system and a method. The radiographic image capture system includes: a radiographic image capture section, an output section and a generation section. The radiographic image capture section has plural radiographic imaging devices are placed adjacent to each other in a predetermined direction. Each of the radiographic imaging devices independently performs an imaging action, a preparatory action that is performed before the imaging action, and a transition action in which the radiographic imaging device transitions, in response to a transition command, from a first state in which the radiographic imaging device performs the preparatory action to a second state in which the radiographic imaging device performs the imaging action. The output section outputs the transition command to the plurality of radiographic imaging devices when imaging condition data has been input. The generation section combines image data acquired by the radiographic imaging devices and generates elongated image data representing an elongated radiographic image.
INTRODUCTION: It remains unclear whether increased perirenal fat (PRF) accumulation is equally related to renal involvement in patients with and without diabetes mellitus (DM). We evaluated the association between PRF volume (PRFV) and low glomerular filtration rate (GFR) and proteinuria in people with or without type 2 diabetes mellitus (T2DM).
RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 473 individuals without T2DM (non-DM, n=202) and with T2DM (DM, n=271). PRFV (cm3), obtained from non-contrast CT, was indexed as PRF index (PRFV/body surface area, cm3/m2). Multivariate-adjusted models were used to determine the ORs of PRFV and PRFV index for detecting estimated GFR (eGFR) decrease of <60 mL/min/1.73 m2 proteinuria onset, or both.
RESULTS: Although body mass index (BMI), visceral fat area, and waist circumference were comparable between the non-DM and DM groups, kidney volume, PRFV, and PRFV index were higher in individuals with T2DM than in those without T2DM. In the multivariate analysis, after adjusting for age, sex, BMI, hypertension, smoking history, and visceral fat area ≥100 cm2, the cut-off values of PRFV index were associated with an eGFR<60 in individuals with DM (OR 6.01, 95% CI 2.20 to 16.4, p<0.001) but not in those without DM.
CONCLUSIONS: PRFV is associated with low eGFR in patients with T2DM but not in those without T2DM. This suggests that PRF accumulation is more closely related to the onset and progression of diabetic kidney disease (DKD) than non-DKD. Clarifying the mechanisms through which PRF influences DKD development could pave the way for novel prevention and treatment strategies.
The optimal treatment for refractory (disease won't go away with standard treatment) or relapsed (disease comes back after going away) solid tumors is unknown. Recent studies have shown some benefit to tandem peripheral blood stem cell transplantation (PBSCT). In a tandem transplant, two transplants are done, one after the other. To do a PBSCT, stem cells ("mother cells" that can become any other type of cell) are first collected from the patient's circulating blood. The patient then undergoes high-dose chemotherapy called the preparative regimen. The preparative regimen destroys not only the tumor cells, but it also destroys all of the normal blood making cells. The collected cells are then given back to the patient to "rescue" the patient from the devastating effects of the preparative regimen. By using a stem cell rescue will are able to give much higher doses of chemotherapy than we would be able to give without the stem cell rescue. To make sure that all of the tumor cells are destroyed, patients in this study will undergo two separate transplants using two different preparative regimens. The preparative regimens will use the best agents that have been found to work against recurrent and refractory solid tumors: Busulfan, Thiotepa, Cyclophosphamide and Melphalan.
The invention relates to a preparation method of traditional Chinese medicine, in particular to a drug capable of increasing gastric motility and treating chronic gastritis and a preparation method thereof. The drug is prepared via mixing drug residues, licorice, poria cocos, fructus evodiae, grifola and rhizoma pinelliae preparata, adding water of five times, soaking for 60 minutes, extracting for 5 hours in heat reflux, filtering to prepare 1000 pieces and then coating icing. The losses of effective ingredients of the drug prepared by the preparation method are reduced. Compared with the traditional process, the yield is increased. Moreover, the drug can be rapidly absorbed in the human body. The effective ingredients are not decomposed during the preparation process, and thus the bioavailability of the drug is improved. Therefore, the preparation method has obvious advantages than the original method. Compared with the product prepared in the original process, the ratio of cream extraction is increased by 3 percent, and the bioavailability can be increased by 13 percent. Therefore, the effects are obvious after process innovation, and the efficacy of the product is improved greatly.
BACKGROUND: Implantable loop recorder (ILR) allows rhythm-monitoring up to 3 years. They are recommended in patients with recurrent syncope and for the detection of atrial fibrillation (AF) in patients with cryptogenic thromboembolic events. AF and syncope occur more often in elderly patients. However, data in this cohort is limited.
METHODS AND RESULTS: All patients ≥ 80 years undergoing ILR-implantation between 2011 and 2022 in our center were included. Permanent pacemaker implantation (PPI) and oral anticoagulation due AF were defined as primary endpoints. Forty-five patients ≥ 80 years were included, 33 because of recurrent syncope and 12 because of suspected AF. The average follow up (FU) was 17.6 months. Overall in 22 patients, ILR-implantation led to a therapeutic consequence (48.9%). In the 12 patients who underwent ILR-implantation for detection of AF, AF was detected in nine patients (75%). In the 33 elderly patients who received ILR-implantation after syncope, 11 underwent PPI during FU (33.3%). One patient accidentally removed the ILR himself via the implantation-wound, and no other ILR-related complications were observed.
CONCLUSION: ILR are effective and safe in elderly patients. AF was often found in patients with suspected AF, especially in patients after catheter ablation of only documented atrial flutter (AFlu). PPI-rate was high in patients with recurrent syncope and ILR-implantation. Further investigations are necessary to determine whether PPI may be considered in elderly patients with syncope even in the absence of a bifascicular block.
The biological role of apurinic/apyrimidinic endonuclease 1/redox factor-1 (Apex1) in modulating systemic inflammation remains unclear. This study aimed to assess the impact of Apex1 deficiency on systemic inflammation triggered by lipopolysaccharide (LPS) in a murine model. The methods involved transcriptomic analysis and assessments of inflammatory responses in age-matched 8-week-old Apex1+/- and wild-type Apex1+/+ mice, generated using the CRISPR/Cas9 system. Apex1+/- mice displayed no overt changes in body weight, however, Apex1 protein expressions in tissues were significantly reduced compared to wild-type mice. Furthermore, in Apex1+/- mice transcriptomic analysis showed that genes associated with antioxidant pathways were downregulated, and levels of superoxide production, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malondialdehyde (MDA) were increased. Moreover, hematological analysis showed increased neutrophil levels and a twofold increase in the count of splenic lymphocyte antigen 6 family member G+ (Ly6G+) neutrophils in the Apex1+/- mice compared to those in Apex1+/+ mice. Furthermore, following LPS treatment, the levels of cytokines and chemokines, including interleukin-1β, interleukin-10, tumor necrosis factor-α, and monocyte chemoattractant protein 1, increased in the Apex1+/- mice. The Kaplan-Meier curve showed a significant reduction in the survival rates of Apex1+/- mice treated with LPS compared to those of Apex1+/+ mice. The hepatic and lung injury scores and Ly6G+ neutrophil infiltration levels also increased in Apex1+/- mice after LPS treatment. These results showed that Apex1 deficiency exacerbated the LPS-induced tissue damage in the lung and liver. These findings illustrate that in vivo Apex1 deficiency exacerbates LPS-induced systemic inflammation, tissue damage, and mortality in a murine model, highlighting the crucial role of Apex1 in mitigating inflammatory responses and maintaining a holistic physiological equilibrium.
Patients receive a loading dose of trastuzumab IV over 90 minutes on week 1, and over 30-90 minutes weekly thereafter. Patients receive irinotecan IV over 90 minutes following trastuzumab weekly for 4 weeks. Courses are repeated every 6 weeks in the absence of disease progression or unacceptable toxicity.
The present invention relates to a carbon dioxide mud pack, capable of converting stiff texture of a mud pack, which is stiffly applied on a skin when in use, into soft and smooth texture like cream. More particularly, the carbon dioxide mud pack comprises a pouch, and the pouch has a structure that two separated spaces are opened through a pressurizing opening part from the outside. In one space of the pouch, a pack composition and carbonate are accommodated, and in other space of the pouch, acid is accommodated. It is possible to store and carry the carbon dioxide mud pack such that the carbonate and the acid does not react with each other, and when in use, by opening the pressurizing opening part, the acid in one space is injected into other space. Reaction is started between the carbonate contained in the pack composition and the acid to generate carbon dioxide, and the carbon dioxide fills an inside of the pack composition. In this way, the carbon dioxide fills spaces between particles forming the pack composition, and a surface of each particle is activated, thereby enabling a user to feel soft and smooth texture when the carbon dioxide mud pack is applied on a skin.
In this paper, we studied the potential genotoxic effects of human plasma from healthy volunteers, as well as patients with gastro-oesophageal reflux disease, Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) using the oesophageal adenocarcinoma cell line (OE33) and the lymphoblastoid cell line (TK6). Both TK6 and OE33 cells were treated with plasma (10 % volume, replacing foetal bovine serum (FBS) or horse serum (HS)) at different time points of 4 h (for the micronucleus (Mn) assay and the invasion assay) and 24 h (for the cell cycle studies). Plasma-induced effects on DNA damage levels, cell viability and the cell cycle were studied by the micronucleus assay, cytokinesis block proliferation index (CBPI) and flow cytometry respectively. The expression of IL-8 in supernatants of TK6 cells and IFN-β in OE33 cells was also analysed by enzyme-linked immunosorbent assay (ELISA). Finally, we carried out an assessment of cellular invasion of OE33 cells following plasma treatment. The results of the micronucleus assay confirmed the genotoxicity of direct plasma treatment from some participants through the increase in DNA damage in TK6 cells. Conversely, some individual patient plasma samples reduced background levels of TK6 cell Mn frequency, in an anti-genotoxic fashion. In TK6 cells, (on average) plasma samples from patients with Barrett's oesophagus induced higher micronucleus levels than healthy volunteers (p= 0.0019). There was little difference in Mn induction when using plasma versus serum to treat the cells in vitro. Cell cycle results showed that direct plasma treatment had a marked impact on OE33 cells at 24 h (p=0.0182 for BO and p=0.0320 for OAC) by decreasing the proportion of cells in the S phase, while plasma exposure was less impactful on the cell cycle of TK6 cells. Invasion of OE33 cells was also seen to be non-significantly affected by plasma treatment of OE33 cells. The addition of N-acetyl cysteine NAC in a dose-dependent matter did not alter the formation of Mn in TK6 cells, suggesting that reactive oxygen species (ROS) are not the root cause of plasma's genotoxicity. The concentration of IL-8 in TK6 cells and IFN-β in OE33 cells was significantly higher in cells treated with OAC-derived plasma than in the untreated negative control. Collectively, our results demonstrate that plasma-specific effects are detectable which helps us better understand some important aspects of the biology of blood-based biomarkers under development.
PURPOSE:To obtain an anti-inflammatory analgesic ointment having low stimulation to the skin compared with conventional ointment and high absorbability, by compounding indomethacin with a basic amino acid as a dissolution agent, a lactic acid ester as an absorbefacient, and further a gelling agent and a thickener. CONSTITUTION:The objective agent can be produced by compounding (A) 0.5-1.5wt% indomethacin, (B) a medium composed of 0.3-10wt% basic amino acid (e.g. lysine, arginine, etc.), 10-60wt% lower alcohol and 20-70wt% water, (C) 0.2-5wt% gelling agent and/or thickener (e.g. carrageenan, CMC, etc.) and (D) 0.2-10wt% lactic acid ester. The carbon number of the alcohol component of the lactic acid ester is preferably 12-18. Since the agent contains a basic amino acid in place of glycol as a dissolution agent, it has weak stimulation to the skin and is free from stickiness. The use of a lactic acid ester as an absorbefacient improves the absorbability of the agent. It can be stored stably for a long period.
Due to an aging society, the number of people diagnosed with dementia is expected to increase dramatically over the next two decades, with a concomitant rise in the number of family members providing informal care for their loved ones. The stresses associated with this care have been well-documented in the scientific literature, and are noted to be associated with increased risk for psychological and physical morbidity, particularly cardiovascular disease. Indeed, caregiving is associated with elevations in negative affect (e.g., depressive and anxiety symptoms), which in turn is associated with biological indicators that are thought to predict CVD risk (e.g., markers of coagulation and inflammation). The primary goal of this study is to examine the efficacy of a brief Behavioral Activation (BA) Treatment, called the Pleasant Events Program (PEP), for reducing biological CVD risk indicators in a sample of Alzheimer caregivers. We will enroll 100 dementia caregivers and randomly assign them to receive 4-sessions of PEP or 4-sessions of support + information. Our PEP intervention will be conducted in caregivers' homes and will emphasize the importance of monitoring and increasing activities that help individuals make contact with natural reinforcers in their environments, identifying and reducing negative coping responses, and selection and achievement of behavioral goals for healthier living. Caregivers will be assessed for our biological outcomes at baseline, post-treatment, and 1-year to determine intervention efficacy. Given the brief nature of the PEP intervention, the ease with which it can be applied in real-world settings (e.g., community agencies providing services to caregivers), and lack of difficult skills for interventionists and caregivers to acquire, we believe our PEP intervention will be easily transferred to "real-world" settings. If our PEP intervention is efficacious, it may have a considerable impact on both the physical and mental health of caregivers, and will likely have public health implications.
Subjects age 18 and above may be included in the study. It is the goal of the study to survey multiple skin locations of humans at multiple time points. The subjects' samples will be analyzed using DNA methods in order to identify the types of microbes present on the swabs. Other substances such as proteins, RNA, and other metabolites may also be analyzed. DNA or other molecular components of the sample will be extracted. Alternately, microbes in the sample can be cultured directly. The samples will be explored using molecular analyses. The backbone of the analyses will be shotgun metagenomic sequencing and 16S rDNA amplicon sequencing. The results of these analyses will be used to identify and describe the microbiome of the skin.
Antimelanoma differentiation-associated protein 5 positive dermatomyositis (MDA5 DM) is a rare subtype of idiopathic inflammatory myopathy. There are limited data available regarding the cutaneous manifestations of MDA5 DM in the African American population. We presented the case of a male patient in his early 20s who presented with debilitating cutaneous ulceration and myopathy. Workup revealed interstitial lung disease (ILD) and positive MDA5 serology consistent with MDA5 DM. He made a remarkable recovery in terms of myopathy and cutaneous ulcerations with a multipronged regimen of prednisone, intravenous immunoglobulin and mycophenolate mofetil. However, there was a progression of ILD on this regimen which warranted use of rituximab.
The invention relates to a preparation method of fritillaria pallidiflora total polysaccharide and application thereof, the method comprises the steps of naturally drying fritillaria pallidiflora bulbs, mechanically crushing, sieving to separate impurities, degreasing by petroleum ether, naturally drying in the air, continuously extracting by using a solvent, centrifuging, concentrating, precipitating by using absolute ethyl alcohol, centrifuging again, and carrying out vacuum freeze drying on polysaccharide precipitate to prepare crude polysaccharide with water solubility, hot water solubility and acid solubility. Purifying the crude polysaccharide, deproteinizing, dialyzing, and separating and purifying with ion exchange resin and sephadex to obtain three neutral sugars. The extraction rate of the total crude polysaccharide extracted by the method reaches 30 percent. The polysaccharide part is proved to have antioxidant activity, and free radicals have scavenging ability. The search for new antioxidants from natural plants is a new direction for the development of modern medicine and food industries; the research on the antioxidation of the polysaccharide and the derivatives thereof and the development of new natural antioxidants have important practical significance. The research can provide reference for the application and development of fritillaria pallidiflora polysaccharide in antioxidant and anti-aging functional food.
<P>PROBLEM TO BE SOLVED: To provide a gene transfer agent capable of more efficiently transferring a gene into a cell in a medium containing blood serum, and a nucleic acid complex in which the gene transfer agent is complexed with a nucleic acid.  <P>SOLUTION: There is disclosed a gene transfer agent comprising a branched-polymer having a plurality of branched-chains that are prolonged from an aromatic ring served as a nucleus. The branched-chain comprises a polymer obtained by randomly copolymerizing at least 2-N, N-dimethylaminoethylmethacrylate and/or its derivatives and 3-N, N-dimethylaminopropylacrylamide. The ratio of constituent units derived from the 3-N, N-dimethylaminopropylacrylamide to the sum of the constituent units derived from the 2-N, N-dimethylaminoethylmethacrylate and/or its derivatives and the constituent units derived from the 3-N, N-dimethylaminopropylacrylamide is 30 mol% or less. There is disclosed a nucleic acid complex comprising the gene transfer agent and a nucleic acid.  <P>COPYRIGHT: (C)2011,JPO&INPIT
The participants assigned to Group 3 will only be instructed on how to apply lavender oil inhalation and keep regular daily records on the chart given. The participants in this group will be given lavender oil in a 10 ml bottle.
Under ultrasound-guide, the desired vessel is punctured with a sharp hollow needle, syringe is detached and guidewire is advanced through the lumen of the needle, and then the needle is withdrawn. Central catheter is then passed over the guidewire into the vessel. The procedure will be performed by experienced practitioner who were defined as board-certified anesthesiologist staffs and had experience of more than 50 central venous catheterizations in both techniques.