anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Human serum albumin particles which are suitable for binding technetium are produced. Human serum albumin purified by dialysis is adjusted to a pH of 9.8 to 10.2 and kept at 71 to 73 DEG C for 10 to 20 minutes. It is then cooled to 45 to 50 DEG C, adjusted to a pH of 6.8 to 7.0 with acid and 0.17 to 0.22% by weight of tin(II) ions, based on the albumin, is added. The pH is adjusted to 5.2 to 4.8 by further addition of acid and a further 1.53 to 1.73% by weight of tin(II) ions, based on the albumin, are added. The temperature is raised to 71 to 73 DEG C and the suspension is subjected to countercurrent sedimentation with physiological saline solution. After decantation of the saline solution, the concentration of the particles is adjusted to 2.5 to 3.0 mg of albumin per millilitre of suspension with sterile distilled water. The suspension is then freeze-dried in vessels precooled to -80 DEG C. The freeze-dried human serum albumin particles can be labelled immediately before use with technetium-99m by adding isotonic sterile pertechnetate solution and shaking briefly.
Conventional images will be taken with standard pulse sequences. These images will be used for the diagnostic examination for which the patient will have been scheduled. Following the diagnostic study, a pulse sequence designed to obtain spectroscopy data will be used.This will be used on the existing magnets 1.5T and 3T. Memorial Sloan-Kettering Cancer Center has 1.5T and 3T magnets. The patient will have only one injection of contrast (gadolinium-DTPA) for the initial diagnostic study. No additional contrast will be administered. The additional sequence should take about 10 minutes, depending on breast size.
The prevalence of child obesity in the U.S. has tripled since the 1970s and excess weight gain - even in young children - is a precursor to adult obesity and associated co-morbidities. In the U.S. it is recommended that children consume whole cow's milk (3.5% fat) from ages 1 to 2 years to support rapid early growth and brain development, and then at age 2 years transition to low-fat (1%) or non-fat milk to reduce saturated fat and calorie intake. However, surprisingly few rigorous trials to support recommendations on optimal milk type have been conducted and existing observational studies paradoxically suggest that lower fat milk consumption is associated with increased adiposity in children. The effects of the types of fat found in milk on cardiometabolic disease risk have also been questioned. This randomized controlled trial will evaluate the effect of consumption of whole versus 1% milk on child adiposity and other health and developmental outcomes beginning after toddlers have successfully transitioned from breastmilk and/or formula to cow's milk at 2 years of age. Investigators will recruit 625 parents of toddlers and randomly assign 625 toddlers to either whole or 1% milk groups for 1 year (with estimated final sample size of 500). Our primary aim is to determine how milk fat type (whole versus 1%) consumed from age 2 to 3 years affects change in adiposity as measured by waist-to-height ratio (primary outcome), body mass index, tri-ponderal mass index, and waist circumference. Secondary aims are to evaluate how milk type consumed from age 2 to 3 years affects changes in milk, total and saturated fat, added sugars, and total energy intake and overall diet quality, as well as blood lipids and vitamin D status, and neurocognitive development. Results from the Milk-TOT Study can help pediatric health care providers give evidence-based dietary recommendations to improve child weight and health, and can inform the types of milk provided to participants in the federal nutrition programs which collectively provide milk to over half of all young children in the U.S.
PCT No. PCT/EP92/00217 Sec. 371 Date Aug. 5, 1993 Sec. 102(e) Date Aug. 5, 1993 PCT Filed Feb. 1, 1992 PCT Pub. No. WO92/13570 PCT Pub. Date Aug. 20, 1992Complexes between internalizing factor-bonding factor conjugates and nucleic acid which can be taken up into higher eukaryotic cells by endocytosis containing, in non-covalently bound form, one or more substances having an affinity for nucleic acid, which are capable of increasing the efficiency of absorption of the complexes into the cells. The non-covalently bound substance having an affinity for nucleic acid may optionally be identical to the bonding factor, preferably a polycationic substance. The internalizing factor is preferably transferrin. Processes for preparing the complexes and processes for introducing nucleic acid into higher eukaryotic cells. Pharmaceutical preparations containing complexes with a therapeutically active nucleic acid.
Patients having had a sprain of the long fingers, within 2 weeks of consultation. This group will receive a single injection of corticoids.
PCT No. PCT/US90/07154 Sec. 371 Date Jun. 8, 1992 Sec. 102(e) Date Jun. 8, 1992 PCT Filed Sep. 7, 1990 PCT Pub. No. WO91/09586 PCT Pub. Date Jul. 11, 1991.These improved compositions include a polymethylalkylsiloxane hair conditioning These improved compositions include a polymethyMcarrier medium such as a hair shampoo, hair conditioner or aerosol spray composition. The polymethylalkylsiloxane is from 0.1% to about 10% by weight of the total composition and is of the general formula: R2(CH3)Si(OSi(CH3)2)x(OSiR'CH3)yOSi(CH3)R2, wherein each R is selected from the group consisting or methyl, ethyl and phenyl groups, R' is an alkyl group of from 8 to about 60 carbon atoms where the total number or R' groups present has an average of at least 12 carbon atoms, the values of x and y are such that the ratio of x:y is in the range of from 97:3 to 55:45, the sum of x+y is greater than or equal to about 60 and less than or equal to about 1,333 and the polymethylalkylsiloxane has a melting transition, as measured by a differential scanning calorimeter, between about -25 DEG  C. to +27 DEG  C. Also claimed is a method of conditioning the hair by applying such a composition to the hair and a method of improving the hair conditioning ability of a cosmetically acceptable hair treating composition by adding such a polymethylalkylsiloxane to such a composition.
Mindset intervention framing food choices as an opportunity to practice self-kindness. Individuals randomized to this arm will participate in a 15-20-minute live virtual educational session delivered via the Stanford Zoom platform. The recording of the session will be available on a private and secure educational platform for those who cannot attend the live session and for future review. After participating in the initial educational session, participants can engage in brief (less than 10 minutes) web-based activities on their own time during weeks 2 and 4.
The antibodies for distinguishing cervical carcinoma cells from normal cells may be obtd. from human hybridomas CLNH5 or 11. The antibodies or their fragments may be labelled, e.g. with a radionucleotide or toxin.  The human hybridoma is obtd. by fusion of B-lymphocytes (from human lymphnodes, lymphglands, bone marrow, spleen or blood, associated with a neoplasm) with a human fusion parther.  The hybridomas are cloned, and the resulting clones are screened for prodn. of monoclonal anti-bodies specific for the tumour cells.  The specific clones are then grown to produce the antibodies.
This group will consist of 110 patients who undergo unplanned, emergency cesarean deliveries at the Emergency Unit of El-hussien Hospital. Indications for emergency cesarean section may include, but are not limited to, fetal distress, placental abruption, cord prolapse, failed induction of labor, or arrest of labor progression. Patients with premature rupture of membranes will be excluded from this group due to their increased risk of infection. Participants in this group will receive urgent pre-operative preparation and post-operative care as per hospital emergency protocols. Their surgical sites will be monitored for signs of infection during their hospital stay and follow-up period, similar to the elective group.
This is a phase 2, randomized, open label, pivotal study to evaluate the efficacy and safety of HQP1351 in CML CP patients who are resistant and/or intolerant to first- and second-generation TKIs in China. A total of 141 CML CP patients will be included in this study. After screening, eligible subjects will be randomized by 2:1 ratio to enter HQP1351 therapy cohort and best available therapy (BAT) cohort. When the subjects in the two cohorts reach EFS assessment, they can crossover to contralateral cohort if the investigator and Sponsor think they could be clinically benefited. During treatment, each subject will be assessed regularly for hematological, cytogenetic and molecular responses. At the same time, safety information also will be evaluated.
The present invention discloses a biologically active basement membrane composition. When polymerized under physiological conditions, the composition forms gel-like structures whose ultrastructure resembles interconnected thin sheets of the lamina densa zone of basement membrane. The major components of the composition include laminin, type IV collagen, heparan sulfate proteoglycan, entactin and nidogen. These components polymerize in constant proportions when redissolved and allowed to reconstitute. Molecular sieve studies on the soluble extract demonstrate that laminin, entactin and nidogen are associated in a large but dissociable complex. The reconstituted matrix is biologically active and stimulates the growth and differentiation of a variety of cells, including epithelial cells, nerve cells, hair follicles and the like. The reconstituted matrix can also be used for determining metastatic potential of tumor cells and for isolating metastatic tumor cells.
Patients included in the study will receive MEOPA with a high concentration mask (bottle stored for at least 48 hours horizontally) at a minimum flow rate of 10 L / min under supervision of a health care worker after explanation of use to the patient in a quiet environment (box). MEOPA will be administered for a maximum total duration of 20 minutes, continuously or not depending on the needs of the patient, but after a continuous phase at the beginning of treatment of at least 3 minutes.
Gasified particles for cosmetic treatments, particularly hair treatments, are described. The gasified particles contain at least one gas enclosed in a solid enveloping material. The enveloping material is selected so that the gas is released on contact of the enveloping material with water or moisture. The release of the gas can be accompanied by a detectable acoustic effect (pop effect). The hair treatment composition also can provide a hair fixing effect. Furthermore an instant gel preparation is described substantially comprising a mixture of dry substances, which contains at least one gel former and at least one solid substance producing a detectable acoustic effect on contact with moisture, especially gasified particles. The gasified particles are used as acoustic indicators for the readiness of the instant preparation after liquid addition.
BACKGROUND: Autofluorescence (AF)-Raman microspectroscopy is a technology that can detect residual basal cell carcinoma (BCC) on the resection margin of fresh, surgically excised tissue specimens. The technology does not require tissue fixation, staining, labelling or sectioning, and provides quantitative diagnosis maps of the surgical margins in 30 min.
OBJECTIVES: To determine the accuracy of the AF-Raman instrument in detecting incomplete BCC excisions during Mohs micrographic surgery (MMS), using histology as the reference standard.
METHODS: Skin layers from 130 patients undergoing MMS at the Nottingham University Hospitals NHS Trust (September 2022-July 2023) were investigated with the AF-Raman instrument. The layers were measured when fresh, immediately after excision. The AF-Raman results and the intraoperative assessment by Mohs surgeons were compared with a postoperative consensus-derived reference produced by three dermatopathologists. The sensitivity, specificity, and positive and negative predictive values were calculated. The study was registered with ClinicalTrials.gov (NCT03482622).
RESULTS: AF-Raman analysis was successfully completed for 125 of 130 layers and, on average, covered 91% of the specimen surface area, with the lowest surface area covered being 87% for the eyelid and the highest being 94% for forehead specimens. The AF-Raman instrument identified positive margins in 24 of 36 BCC-positive cases [67% sensitivity, 95% confidence interval (CI) 49-82] and negative margins in 65 of 89 BCC-negative cases (73% specificity, 95% CI 63-82). Only one of 12 false-negative cases was caused by misclassification by the AF-Raman algorithm. The other 11 false-negatives cases were a result of no valid Raman signal being recorded at the location of the residual BCC due to either occlusion by blood or poor contact between tissue and the cassette window. The intraoperative diagnosis by Mohs surgeons identified positive margins in 31 of 36 BCC-positive cases (86% sensitivity, 95% CI 70-95) and negative margins in 79 of 89 BCC-negative cases (89% specificity, 95% CI 81-95).
CONCLUSIONS: The AF-Raman instrument has the potential to provide intraoperative microscopic assessment of surgical margins in BCC surgery. Further improvements are required for tissue processing, to ensure complete coverage of the surgical specimens.
Pulp necrosis is the most common complication following dental trauma and is often associated with apical periodontitis. The management of these teeth is challenging in terms of large root canals, open apices, thin dentinal walls, and short roots. Over decades the conventional treatment for these teeth was calcium hydroxide apexification, a time-consuming procedure despite high success rates. Subsequently after the introduction of mineral trioxide aggregate and hydraulic calcium silicate materials single visit apical plug procedures became increasingly practiced with comparable success rates to the conventional apexification. The search continued afterward for a clinical procedure that may stimulate further root development and apical closure to avoid the long-term complication of root fracture after apexification. Regenerative procedures using stem cells derived from the apical papilla and blood clots as scaffolds were then introduced for the management of immature teeth, with variable protocols and success rates. This review will cover the evidence available and current position of regenerative endodontic procedures in traumatized immature teeth with apical periodontitis, in terms of clinical protocols, outcome, and potential prognostic factors.
PURPOSE: Protective and therapeutic vaccines including vaccines for herpes simplex virus are provided. CONSTITUTION: Signal peptide deletions were constructed to be localized to the cytoplasm and perhaps be misfolded. This provides a means by which more gD is transported to the proteosome, resulting in more gD derived peptide being able to complex with MHC Class 1 molecules. This boosts the cellular response to gD. There are two signal peptide deletion type constructs. One has a TMR and the other does not. Both types of proteins are expected to be localized to the cytoplasm but may have differences in distribution within the cytoplasm based on differences in their hydrophobicity.
This is a prospective, randomized, single-blind, controlled, multi-center study for subjects undergoing VLU treatment. Qualified subjects will be randomized (1:1); test group (PRP Concepts Fibrin Bio-Matrix) and control group (usual and customary practice). The study will consist of 3 periods: a screening period, an active treatment period, and a follow-up period (if healed). Approximately 250 subjects will be enrolled. Subjects will be ≥18 years of age with a VLU (greater than 4 weeks duration). Each subject will be enrolled in the active treatment period for up to 12 weeks, or to closure of wound with a confirmatory visit 2 weeks after wound closure, whether such closure occurs at 12 weeks or earlier.
Crystalline pigment or stain compositions having high color strength and/or low sugar content, and methods and processes for making the same. The composition may comprise purified fruit and/or plant colour juice. Unique dry color obtained from natural sources including plants such as fruits, vegetables and algae. The pigment is obtained from red grape juice and/or purple carrot anthocyanin juice. The method of preparing the dried colorant includes purifying the color pigment using various purification techniques and then removing water using a low temperature drying process. The combination of purification techniques and low temperature drying results in unique natural colorants that are color purity and/or low sugar. The colorant exhibits good storage stability and/or handling characteristics including, but not limited to, density, flowability, water dispersibility, and/or hygroscopicity.
The invention discloses a bivalent inactivated vaccine for mycoplasma capricolum pneumonia and chlamydia psittaci disease and a preparation method thereof. The active ingredients of the bivalent inactivated vaccine comprise MOMP proteins of inactivated mycoplasma filiformis goat subspecies, inactivated mycoplasma ovipneumoniae and inactivated chlamydia psittaci. The amino acid sequence of the MOMP protein of Chlamydia psittaci is shown as sequence 2 in the sequence table. The mycoplasma ovipneumoniae is mycoplasma ovipneumoniae SH-01CGMCC No. 16503. The filamentous mycoplasma goat subspecies is filamentous mycoplasma goat subspecies GT-01CGMCC No. 16504. Experiments prove that the bivalent inactivated vaccine has good safety for immunizing both experimental animals and target animals, and can effectively prevent the experimental animals and the target animals from being infected by the goat mycoplasma pneumonia and the chlamydia psittaci. Has important significance for preventing and controlling the prevalence and the spread of the mycoplasma pneumoniae of goats and the chlamydia psittaci disease. The invention has important application value.
Participants who received placebo during the Induction Phase (from Cohorts 1 and 3) and achieved a CDAI-70 response at Week 14 will undergo a sham randomization into the Maintenance Phase. Placebo responders from induction will receive blinded maintenance treatment with an SC injection of placebo once every 4 weeks (q4w) from Week 16 to Week 64.
The retention of calcium oxalate monohydrate (COM) crystals on cell membranes is pivotal in kidney stone formation. However, the mechanisms underlying COM attachment to neutral lipid membranes remain unclear. In this study, we demonstrate that COM exhibits size-selective adhesion to fluid lipid membranes composed of lipids with distinct sizes. Specifically, the (100) facet of COM induces the formation of new domains and establishes strong adhesion in the 18:1 (Δ9-Cis) PC (DOPC) membrane, while the (010) facet induces domains with strong adhesion in the 16:0-14:0 PC membrane. This selectivity is linked to the compatibility of the area per lipid in DOPC with the unit cell area of the (100) facet and the area per lipid in 16:0-14:0 PC with the (010) facet. Our Raman spectroscopic analyses reveal that the lipid acyl chains within these induced domains exhibit a higher degree of ordering compared to the typical fluid state of the membrane. This ordered structural alignment, combined with the lateral size-matching effect, suggests the potential formation of molecular arrays within the lipid bilayer that are in harmony with the lattice dimension of COM. To elucidate the strong adhesion between calcium oxalate and the phospholipid head group in the absence of a direct molecular structural correspondence, we propose that crystal water associated with COM can form hydrogen bonds with the phospholipid head group. Using structure visualization software, we demonstrate the feasibility of such hydrogen bonding networks. The formation of this network could serve to stabilize and enhance the attachment of COM to the lipid membrane. This mediation by water molecules offers a plausible explanation for the pronounced affinity at the interface.
Long non-coding RNAs (lncRNAs) are involved in the control of critical tumor-suppressor and oncogenic pathways in cancer. These types of non-coding RNAs could affect both immune and cancer cells. The thorough analysis of lncRNAs derived from immune cells and the incorporation of new findings significantly advance our understanding of the complex role of lncRNAs in the context of cancer. This work highlights the promise of lncRNAs for translational therapeutic approaches while also establishing a solid foundation for comprehending the complex link between lncRNAs and cancer through a coherent narrative. The main findings of this article are that types of lncRNAs derived from immune cells, such as MM2P and MALAT1, can affect the behaviors of cancer cells, like invasion, angiogenesis, and proliferation. As research in this area grows, the therapeutic potential of targeting these lncRNAs offers promising opportunities for expanding our understanding of cancer biology and developing cutting-edge, precision-based therapies for cancer therapy.
Rationale: The epidemiology, management, and outcomes of acute respiratory distress syndrome (ARDS) differ between children and adults, with lower mortality rates in children despite comparable severity of hypoxemia. However, the relationship between age and mortality is unclear.Objective: We aimed to define the association between age and mortality in ARDS, hypothesizing that it would be nonlinear.Methods: We performed a retrospective cohort study using data from two pediatric ARDS observational cohorts (n = 1,236), multiple adult ARDS trials (n = 5,547), and an adult observational ARDS cohort (n = 1,079). We aligned all datasets to meet Berlin criteria. We performed unadjusted and adjusted logistic regression using fractional polynomials to assess the potentially nonlinear relationship between age and 90-day mortality, adjusting for sex, PaO2/FiO2, immunosuppressed status, year of study, and observational versus randomized controlled trial, treating each individual study as a fixed effect.Measurements and Main Results: There were 7,862 subjects with median ages of 4 years in the pediatric cohorts, 52 years in the adult trials, and 61 years in the adult observational cohort. Most subjects (43%) had moderate ARDS by Berlin criteria. Ninety-day mortality was 19% in the pediatric cohorts, 33% in the adult trials, and 67% in the adult observational cohort. We found a nonlinear relationship between age and mortality, with mortality risk increasing at an accelerating rate between 11 and 65 years of age, after which mortality risk increased more slowly.Conclusions: There was a nonlinear relationship between age and mortality in pediatric and adult ARDS.
FIELD: medicine, pharmacy. SUBSTANCE: invention proposes the oral agent as granules or tablets made of core, water-soluble intermediate layers and external layer showing stability to gastric juice. Tablet core has pantoprazol as an active component in combination with buffer inorganic basic compound, preferably, sodium carbonate, and binding agent - polyvinylpyrrolidone and/or hydroxypropylmethylcellulose, and filling agent - mannitol. Granule has pantoprazol and polyvinylpyrrolidone and/or hydroxypropylmethylcellulose. EFFECT: improved quality and property of agent. 6 cl