anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the field of medicines, and concretely relates to a dysmenorrhea treatment medicine. The dysmenorrheal treatment medicine comprises 15g of Radix Paeoniae Rubra, 20g of Chinese angelica, 15g of Ligusticum wallichii, 20g of Rhizoma Cyperi, 20g of Radix Curcumae Aromaticae, 15g of dry ginger, 5g of mint, 15g of Combined Spicebush Root, 15g of Radix Codonopsis, 20g of Radix Astragali, 15g of Rhizoma Atractylodis Macrocephalae and 10g of Bamboo Shavings. A preparation method of the medicine comprises the following steps: mixing the above medicines, rapidly flushing, immersing for 2h, boiling for 30min three times, filtering, concentrating the obtained filtrate, and processing through a routine traditional Chinese medicinal preparation method to prepare an oral liquid. An administration method of the medicine is characterized in that the medicine is taken one dose every day for 7d before menstrual onset and after the dysmenorrhea, 1g of the dose equals to 1kg of raw medicines, whether dysmenorrhea is cured before next menstrual onset, the administration is paused if the dysmenorrhea is cured, and the medicine is continuously administrated for 7d if the dysmenorrhea does not disappear. The medicine is used for treating the dysmenorrhea, and has the efficacies of energy invigorating, blood circulation invigorating, qi rectifying and pain relieving. The medicine is clinically used to treat 28 patients suffering the dysmenorrhea, and a one year follow-up result shows 27 patients are cured and one patient is pregnant after marriage.
The invention provides compound essential oil with the effects of inducing resuscitation and refreshing mind, and a preparation method and application thereof. The preparation method comprises the following steps of: peppermint essential oil, storax essential oil, jasmine essential oil, cassia twig essential oil and basil essential oil. The compound essential oil is prepared by utilizing the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicine, adopting storax essential oil as monarch drug, adopting jasmine and peppermint essential oil as ministerial drug, adopting cassia twig essential oil as assistant and matching with basil essential oil as guide, and can improve symptoms such as dizziness caused by hypoxia. The preparation method comprises the step of uniformly mixing the preparation raw materials according to the proportion. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, and has the advantages of rich raw materials and scientific formula ratio. Experimental study shows that the anti-hypoxia effect is remarkable.
At the start of each level with the exception of 100 mg level which there are only two subjects, two sentinel subjects will be randomized 1:1 to 162 or placebo. The remaining subjects will be randomized 5:1 to receive a single ascending dose of 162 or placebo.
The alkaline phosphatase-to-albumin ratio (APAR) is correlated to worse prognosis in coronary artery disease, cancer, and acute renal failure. However, the relationship between APAR and sepsis prognosis has received little research. The content of this research was to investigate the prognostic relationship between APAR and sepsis. And validate the stability of the correlation in 90-days and 1-year mortality. Retrospective cohort research was conducted basing MIMIC-IV database (version 2.0). The hazard ratio (HR) and 95% confidence interval (Cl) were computed using multivariate Cox regression analysis. In addition, plots of survival curves and subgroup analyzes were conducted. Receiver operating characteristic (ROC) curves were also used. 9741 participants were included in this investigation. The 90-days mortality was 32.8%, and the 1-year mortality was 42.0%. After controlling for confounders, the adjusted HRs (95% CI) for tertile 2 (2.2-3.8) and tertile 3 (> 3.8) were 1.37 (1.25-1.51) and 1.74 (1.58-1.91), respectively. The Kaplan-Meier curve analysis showed a higher probability of 90-days death in the higher APAR group. The area under the curve (AUC) of APAR was 0.674 and could reach 0.709 after combining the Oxford Acute Severity of Illness Score (OASIS). This study demonstrates that APAR is significantly related to bad clinical outcomes in sepsis.
PCT No. PCT/JP94/00895 Sec. 371 Date Feb. 5, 1996 Sec. 102(e) Date Feb. 5, 1996 PCT Filed Jun. 2, 1994 PCT Pub. No. WO94/29340 PCT Pub. Date Dec. 22, 1995A DNA fragment encoding a novel human-derived tumor cell growth inhibitor can be obtained from a cDNA library originating from human colon tumor cell, using as a DNA probe a DNA fragment encoding mouse human-derived tumor cell growth inhibitor. An expression plasmid bearing a promoter originating from Bacillus brevis, a signal peptide originating from Bacillus brevis and a DNA fragment encoding human-derived tumor cell growth inhibitor downstream of the signal peptide is constructed and Bacillus brevis is transformed by the expression plasmid. The resulting transformant is incubated to secret the novel inhibitor out of the cell so that the novel inhibitor can be produced efficiently.
PURPOSE: To make a plaster usable in an outer skin test, especially to identify an allergic contact dermatitis by providing the plaster with at least one activating matter storing or absorption means placed on a carrier film. CONSTITUTION: By directly applying a polymer solution on a web supporting film 11, then evaporating the solvent, a web carrier film 12 may be produced. Next, a film material engaging ring 15 is installed concentrically to a disk like activating matter absorption means 14, and the edge of the ring which protrudes over the disk is fixed to a contact adhesive layer 13. And, the carrier film 12 with contact adhesive is removed of its each strip parallel to the both outer edges of the web by a certain depth of extracting or cutting-in to form the supporting film 11. The supporting film 11 protrudes over one edge of the carrier film 12 forming a handling part when the same is plastered on. A protective layer 16 is covering the activating matter absorption means 14 and the engaging ring 15 until the whole plaster is plastered on.
This study aimed to evaluate the adverse effects of particulate matter (PM) exposure on endometrial cells and fertility and to identify possible underlying mechanisms. Thirteen women (aged 15-52 years) were included in this study. Enrolled patients underwent laparoscopic surgery at Gangnam Severance Hospital between 1 January and 31 December 2021. For in vivo experiments, 36 female and nine male C57BL/6 mice were randomly divided into control(vehicle), low-dose(10 mg/kg/d), and high-dose exposure groups(20 mg/kg/d). PM was inhaled nasally for four weeks and natural mating was performed. NIST® SRM® 1648a was used for PM exposure. qRT-PCR, western blotting and Masson's trichrome staining were performed. PM treatment in human endometrial stromal cells induced inflammation with significant upregulation of IL-1β, p-NF-kB, and p-c-Jun compared to those of controls. Additionally, PM treatment significantly increased apoptosis in human endometrial stromal cells by downregulating p-AKT and upregulating p-p53/p53, Cas-3, BAX/Bcl-2, p-AMPK, and p-ERK. After PM treatment, the relative expression of IL-1β, IL-6, TNF-α, p-NF-κB, p-c-Jun, and p-Nrf2/Nrf2 significantly increased in murine endometrium compared to those of the controls. Expression of apoptotic proteins p53, p27, and Cas-3, was also significantly elevated in murine endometrium of the PM exposure group compared to that of the controls. A significant increase in expression of procollagen Ⅰ, and Masson's trichrome staining scores in the murine endometrium was noted after PM treatment. PM treatment significantly decreased ERα expression. After natural mating, all 3 female mice in the control group gave birth to 25 offspring (mean 8.1), whereas in the low-dose PM treatment group, two of three female mice gave birth to nine offspring (mean 4.5). No pregnant mice or offspring was present in the high-dose PM treatment group. PM exposure induces adverse effects on the endometrium through aberrant activation of inflammatory and apoptotic pathways and is associated with detrimental effects on murine fertility.
BACKGROUND AND AIMS: We aimed to define gender-specific, optimal alanine aminotransferase (ALT) cut-off values for the prediction of significant liver histological changes (SLHC) in Chinese patients with grey zone (GZ) chronic hepatitis B (CHB) and normal ALT.
METHODS: In a retrospective study, we included 1101 consecutive patients with GZ CHB and normal ALT assigned to training or internal validation cohorts. We included an independent cohort of 842 patients for external validation. We performed receiver operating characteristic (ROC) curve, smoothed curve fitting, and threshold effect analyses to determine optimal ALT cut-off values. Area under the curve (AUC) values were calculated to assess their predictive performance.
RESULTS: A proportion of 79.3% of patients with GZ CHB and normal ALT (≤40 U/L) had SLHC. ROC curve analysis initially identified optimal ALT cut-off values of 29 U/L (male) and 22 U/L (female). After smoothed curve fitting and threshold effect analyses, new optimal cut-off values were 27 U/L for males and 24 U/L for females. AUCs for these values were 0.836 (male) and 0.833 (female) in the internal validation cohort, and 0.849 (male) and 0.844 (female) in the external validation cohort. The accuracy and discriminative ability of the newly defined ALT cut-off values were greater than those of the current recommendations.
CONCLUSION: This study established novel optimal ALT cut-off values for more precise prediction of SLHC among Chinese patients with GZ CHB and normal ALT levels. This may help identify individuals who will benefit from timely antiviral therapy.
BACKGROUND: The progressive aging of the population has meant the increase in elderly patients requiring an urgent surgery. Older adults, especially those with frailty, have a higher risk for complications, functional and cognitive decline after urgent surgery. These patients have their functional and physiological reserve reduced which makes them more vulnerable to the effects of being bedridden. The consequences are at multiple levels emphasizing the functional loss or cognitive impairment, longer stays, mortality and institutionalization, delirium, poor quality of life and increased use of resources related to health. We aim to determine whether postoperative physical rehabilitation can prevent functional and cognitive decline and modify the posterior trajectory.
METHODS/DESIGN: This study is a randomized clinical trial, simple blinded, conducted in the Department of Surgery of a tertiary public hospital in Navarra (Hospital Universitario de Navarra), Spain. Patients >  = 70 years old undergoing urgent abdominal surgery who meet inclusion criteria will be randomly assigned to the intervention or control group. The intervention will consist of a multicomponent physical training programme, which will include progressive and supervised endurance, resistance and balance training for 4 weeks, twice weekly sessions with a total of 8 sessions, and the group control will receive the usual care. The primary outcome measure is the change in functional (SPPB) and cognitive status (Mini-Mental State Examination) and the change of quality of life (EuroQol-5D-VAS) during the study period. The secondary outcomes are postoperative complications, length of stay, delirium, mortality, use of health resources, functional status (Barthel Index and handgrip strength tests), cost per quality-adjusted life year and mininutritional assessment. The data for both the intervention group and the control group will be obtained at four different times: the initial visit during hospital admission and at months 1, 3 and 6 months after hospital discharge.
DISCUSSION: If our hypothesis is correct, this project could show that individualized and progressive exercise programme provides effective therapy for improving the functional capacity and achieve a better functional, cognitive and quality of life recovery. This measure, without entailing a significant expense for the administration, probably has an important repercussion both in the short- and long-term recovery, improving care and functional parameters and could determine a lower subsequent need for health resources. To verify this, we will carry out a cost-effectiveness study. The clinical impact of this trial can be significant if we help to modify the traditional management of the elderly patients from an illness model to a more person-centred and functionally oriented perspective. Moreover, the prescription of individualized exercise can be routinely included in the clinical practice of these patients.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05290532. Version 1. Registered on March 13, 2022.
Practicing medicine in an austere environment is fraught with challenges. One primary challenge is that clinicians will frequently be practicing without the supplies needed for specific indicated purpose. For treatment of a cutaneous abscess, sterile gloves are readily available whether at home or when deployed. It can be much more difficult to come across a penrose or vessel loop. In addition, follow up for wound repacking and reassessment is a struggle. Patients may have to move from location to location or have work hours that make it difficult to return to the clinic. The loop technique utilizing the rolled ring of a sterile glove solves both of these problems. Sterile gloves are always available and the Loop technique requires little to no follow up. Additional benefits include: subjects may experience less pain, improved cosmesis, faster healing, and decreased complication rates with incision and loop drainage utilizing the rolled ring of a sterile glove compared to traditional incision and drainage.
Parents are taught strategies on how to interact with their children to increase their skills. Parent training sessions are given 2 times a month at our center and once a month at home for 60-90 minutes each. Treatment will last for 6 months.
Feeding difficulties are common in infants born premature and with medical complexity, particularly those with congenital heart disease. One of the most common strategies for managing feeding difficulties is changing the milk flow rate of the bottle nipple. Milk flow is the rate at which milk transfers from the bottle to the infant's mouth. During swallowing, the vocal folds must close to prevent aspiration of fluid into the airway. When milk flow is fast, the infant must swallow frequently to clear the bolus of fluid and prevent aspiration; this is done at the expense of respiration. When the milk flow rate is slowed, the infant can swallow less frequently, allowing better integration of respiration, and has more time to coordinate an effective swallow. While there is some very limited evidence that slower milk flow rate improves feeding in infants born premature and with congenital heart disease, the underlying mechanisms for improvement of feeding remain unknown. This project will be the first to evaluate the effect of milk flow rate on swallowing function under fluoroscopy to better understanding how swallowing changes under different conditions of flow in young infants. This research will provide the evidence needed to support the use of this simple intervention (i.e., changing the flow rate) in infants at risk for feeding difficulty and swallowing dysfunction.
MP is the energy transmitted over time to the respiratory system during mechanical ventilation. Although mechanical ventilation is a life-supporting treatment, it has the potential to cause damage to the lung structure in a process referred to as VILI. Recently, the degree of VILI has been associated with the amount of energy transmitted to the respiratory system by the mechanical ventilator within a specific time frame, which is referred to as mechanical power. After the occurrence of Covid-19, the search for parameters to reduce lung damage, especially following VILI and ARDS, has become more prominent. In this regard, promoting lung protection requires the more widespread use of mechanical power. We aimed to investigate the effect of bilateral rectus sheath and OSTAP block applied to patients on mechanical power.
On top of a healthy, eucaloric diet, study subjects consume a 40% calory surplus by consuming commercially available sugar-sweetened beverages. Subjects consume these sugar-sweetened beverages 3 times a day in between meals, which results in an increase in meal frequency.
Participants will come in for three session. During one session, participants will first complete a 10-puff product use bout with JUUL, and then a 90-minute ad lib product use bout with JUUL (the session will be approximately 3 hours). During one session, participants will first complete a 10-puff product use bout with IQOS, and then a 90-minute ad lib product use bout with IQOS (the session will be approximately 3 hours). During one session, participants will first complete a 10-puff product use bout with their own brand cigarettes, and then a 90-minute ad lib product use bout with their own brand cigarette (the session will be approximately 3 hours). The order of the sessions will be determined randomly and data about session will not be recorded or used in the analysis.
The compositions and the methods are used for extending the survival of the graft tissue in a host recepient in order to avoid any acute rejection of the graft and reduce the immunologocal consequences of the failure of the graft. The rejection of a tissue graft can be inhibited by using CD40:CD154 interupter of binding be it individual or in combination with another immunomodulator or immunosuppressor. The synergic combination includes CD40:CD154 interrupter of binding and CD28 interrupter of feeding the signal. An example for a CD40:CD154 connection interrupter is an anti-CD154 monoclonal antibody as an antibody having antigen-specific characteristics of binding of 5c8 monoclonal antibody. An example for CD28 interrupter of signalling is CTLA4-lg merged protein. 51 claims
Subarachnoid hemorrhage (SAH) remains one of the most devastating forms of stroke. Over 25% of all stroke related potential years of life lost are from SAH. Outcomes are adversely affected by secondary ischemia from cerebral vasospasm, along with cardiac complications. Trials performed in patients with SAH have demonstrated benefit after the administration of beta blockers - reducing mortality nearly in half; but concerns over diminishing cerebral perfusion inhibited the widespread adoption of this therapy. Our specific aims are as follows: 1. To evaluate the clinical effect of esmolol treatment on cardiac systolic and diastolic function, along with cardiac electrophysiology; 2. To assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; 3. To explore the safety of esmolol shortly after SAH. The primary outcome will be change in systolic function - ejection fraction by Simpson's rule (baseline versus Day 7 +/- 2 after SAH).
BACKGROUND: The soft-tissue glideplanes of the face are functionally important and have a role in facial rejuvenation surgery. The aim of this study was to improve understanding of soft-tissue mobility of the face and its effect on the redraping of tissues involved in face lifting. The consequences of no-release and extensive-release lifting were analyzed to explain the difference in efficacy and potential longevity between these 2 contrasting philosophies.
METHODS: Preliminary dissections and macrosectioning were followed by a definitive series of standardized layered dissections on 50 cadaver heads, along with histologic analysis, sheet plastination, and mechanical testing.
RESULTS: The previously described spaces are potential surgical dissection planes deep to the superficial fascia layer. The classically described retaining ligaments are local reinforcements of a system of small retaining fibers (retinacula cutis and deep retinacula fibers) that provide support to the soft tissues of the face and neck against gravitational sagging while allowing certain mobility. This mobility is used when mobile tissues are lifted without surgical release. However, the process of dragging up these fibers results in a loss of their previous antigravitational, supportive orientation.
CONCLUSIONS: No-release lifting techniques, such as thread lifts and minimal-invasive face lifts, tighten tissue laxity with a change of the gravity-opposing tissue architecture, placing the weight of the flap solely on the fixation, which limits longevity of the lift. The alternative-full release with redraping-enables reattachment of the flap to a higher position, with preservation of the original deep fascial architecture with its antigravity orientation and natural mobility, conceivably improving the longevity of the lift.
A cosmetic or therapeutic preparation for topical application to the skin comprises an additive in the form of an aqueous and/or alcoholic or oleoginous solution or suspension of a crystalline alcohol-soluble substance isolated by multi-stage extraction of reticular organs of a warm blooded animal. Specified are the spleen, livers and lymphatic glands of cattle, including calves.  The comminuted spleen of cattle are extracted with acidified aqueous ethanol, the extract adjusted to pH 6.0, the precipitate removed, the clarified liquid is acidified, concentrated and extracted with benzene.  After washing with water and concentration, the extract is dissolved in ether and concentrated until crystals form.  The crystals are purified by recrystallisation from acetone and ethanol.  The extract may be incorporated in skin creams, face lotions, cleansing creams, shampoos, hairwashes, hair setting agents, hair cream, hair rinsing agents, face powder, face pack, skin powder, foot powder, body powder, make-up, lipsticks, eyebrow sticks, soaps, permanent hair-waving preparations, sunburn creams and oils, nail varnish, hair colouring preparations, corn plasters and adhesive plasters.  The other components are appropriate to the cosmetic or therapeutic formulation.
The invention relates to the field of daily used chemicals and especially relates to Chinese herbal medicine hand cream. The Chinese herbal medicine hand cream utilizes Chinese herbal medicines as extraction raw materials and has effects of making finger smoot and moist, treating chilblain and dampness itching, and relieving swelling and promoting blood circulation. The Chinese herbal medicine hand cream comprises wild chrysanthemum flower, licorice root, glycerin, elastin, spermaceti wax, amino acid, vitamin E, Japanese polypody rhizome, and whitebackleaf mallotus root. The Chinese herbal medicines used by the Chinese herbal medicine hand cream produce synergism so that the Chinese herbal medicine hand cream has functions of treating chilblain, relieving swelling and promoting blood circulation, and treating dampness itching. Japanese polypody rhizome can kill fungi on the skin surface and has effects of clearing heat, removing toxins, invigorating blood circulation and dissipating blood stasis, and treating finger sore. Whitebackleaf mallotus root can treat skin dampness itching.