anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain the subject medicine having excellent vascularization inhibitory action and easy to synthesize by including a new 9α-fluoro-6α- methylprogesterone derivative as an active ingredient. SOLUTION: This inhibitor includes a progesterone compound of formula I (R is H, acetyl or a 1-17C alkyl; R<2> is H or hydroxyl group) or a salt thereof. The compound of formula I is e.g. 6α-methyl-11β, 17α, 21-trihydroxy-4- pregnene-3,20-dione. The compound of formula I is obtained e.g. by treating a 9α-fluoroprogesterone compound of formula II, such as fluorometholone, with a metal catalyst, e.g. rhodium. It is preferable that the compound of formula I is used as a pharmaceutical composition in combination with usual pharmaceutical carrier(s) and that this compound is administered at a daily dose of 0.1-600 mg per adult in one to five portions. This compound is useful e.g. for the treatment of cancer.
The successful implementation of remote ischaemic conditioning as a clinical neuroprotective strategy requires a thorough understanding of its basic principles, which can be modified for each patient. The mechanisms of glutamate homeostasis appear to be a key component. In the current study, we focused on the brain-to-blood glutamate shift mediated by glutamate transporters (excitatory amino acid transports [EAATs]) and the effect of remote ischaemic preconditioning (RIPC) as a mediator of ischaemic tolerance. We used model mimicking ischaemia-mediated excitotoxicity (intracerebroventricular administration of glutamate) to avoid the indirect effect of ischaemia-triggered mechanisms. We found quantitative changes in EAAT2 and EAAT3 and altered membrane trafficking of EAAT1 on the cells of the choroid plexus. These changes could underlie the beneficial effects of ischaemic tolerance. There was reduced oxidative stress and increased glutathione level after RIPC treatment. Moreover, we determined the stimulus-specific response on EAATs. While glutamate overdose stimulated EAAT2 and EAAT3 overexpression, RIPC induced membrane trafficking of EAAT1 and EAAT2 rather than a change in their expression. Taken together, mechanisms related to glutamate homeostasis, especially EAAT-mediated transport, represents a powerful tool of ischaemic tolerance and allow a certain amount of flexibility based on the stimulus used.
Osteochondrosis (OC) is a developmental orthopaedic disease of significant concern in numerous sport horse breeds, with significant international relevance. Using digital radiographs, we assessed the occurrence of hock (tarsocrural joint) OC in 3 048 Pura Raza Española (PRE) horses which took part in a morpho-functional test, in three specific locations in the tarsus limbs: the Distal Intermediate Ridge of the Tibia (DIRT), the lateral trochlear ridges of the talus (LTT), and the medial trochlear ridges of the talus (MTT). An incidence rate of 13.3% was found for hock OC in the analysed sample, with the highest incidence rate observed in DIRT (10.0%) and the lowest in MTT (0.2%). Estimates of genetic predisposition to hock OC were carried out using three genetic approaches: 1a) a binomial threshold model based on the presence or absence of OC, 1b) a multinomial threshold model, on a scale from 0 (absence) to 3 (maximum), and 2) a linear model. The effects considered in the models included sex, genetic origin and stud class. All the analyses were based on the Bayesian inference methodology, using the THRGIBBS3F90 software. The binomial threshold model yielded the most suitable results, with an estimated heritability for Overall hock OC of 0.71 ± 0.055 on the underlying scale (0.53 on the observed scale), ranging in different locations from 0.48 ± 0.087 (LTT) to 0.66 ± 0.063 (DIRT) on the underlying scale (0.10 and 0.38 on the observed scale, respectively). The highest significative genetic correlation was observed between Overall and DIRT (0.97) for approach 1a, and the lowest significant genetic correlation was between Overall and LTT (0.49), for approach 2. This study contributes valuable insights into the genetic predisposition towards, as well as for the potential for selective breeding against, hock OC in PRE horses, and provides a basis for future research and breeding programmes aimed at minimising the occurrence of hock OC and promoting the overall health of this breed.
OBJECTIVE: Although the lack of progress in reducing obesity is a global problem, different places have different contributing factors. One of the factors currently contributing to the increasing prevalence of obesity is emotional eating. The aim of this paper was to describe and compare the level of emotional eating and to analyse which variables and to what extent they affected the other variables.
METHODS: A descriptive cross-sectional study was conducted in students from 3 universities of the Iberian Peninsula (n=1,654) between October 2019 and June 2020. Data were collected through an online self-report questionnaire which included sociodemographic and anthropometric data and validated questionnaires such as: the Emotional Eaters Questionnaire, the ShortForm-36 and the Hospital Anxiety and Depression Questionnaire. Stratified random sampling was performed by faculty, degree, and class groups. For descriptive results, means, standard deviation and relative frequencies of variables were calculated. Student's t-test, chi-square and ANOVA were used to compare means. Simple and multiple linear regressions were performed for both samples.
RESULTS: The mean emotional eating score was 8.77±5.66 for spanish students and 10.02±6.19 for portuguese students, with a difference of 3.62 (<0.001). In Spain, the dependent variable that most affected emotional eating was quality of life (13.8% variance [<0.001]), while in Portugal it was anxiety (10.1% variance [<0.001]).
CONCLUSIONS: Statistically significant differences are found in the level of emotional eating between populations. In addition, there is dissimilarity in the variables influencing the principal in both countries. These findings imply that they should be considered in the design of future research or health interventions.
Patients with UC will be recruited and consented prior to colonoscopy or flexible sigmoidoscopy. All patients will be age 18 or older with a known history of UC that has been confirmed by biopsy and an extent of disease of at least 20cm proximal to the anus. Clinical data will be collected on the patient's age, disease duration, family history of IBD, smoking status and history, as well as current medications for IBD through a questionnaire. Data will also be collected regarding current vitamin D supplementation (if taking) and dose. Prior to the endoscopic procedure, peripheral blood will be drawn into two 10ml red top tubes. At the time of endoscopy, five standard size mucosal pinch biopsies will be obtained from 20cm proximal to the anus. . A bar-coded unique identifier label will be applied to each sample. One biopsy will be placed in formalin. Paraffin samples will be maintained at room temperature. Following to the endoscopic procedure, the patient's physician will complete a Mayo score based on the patients current symptoms and endoscopic disease severity. Comparison will be made between disease activity, serum serum 25 hydroxyvitamin D level, and mucosal expression of tight junction proteins as well as proinflammatory cytokines.
Postoperative pain is one of the commonest feared surgical side effect which can lead to patient dissatisfaction. It occurs due to a combination of inflammatory reaction and an injury to neural tissue caused by the surgical incision. Anterior nasal packing is not an innocuous procedure. It causes discomfort/pain (especially upon removal), nasal mucosa trauma, epiphora, local infection, discomfort in swallowing, sleep disturbances and, very rarely, toxic shock and vagal reflex. Although systemic opioids are traditionally used in the management of postoperative pain, their use is still limited by their possible side effects. Opioid drugs mimic the actions of the endogenous opioid peptides by interacting with specific receptors, the opioid receptors which are μ, δ and κ. The μ receptor is important in sensory processing, including the modulation of nociceptive stimuli, extrapyramidal functioning and in limbic and neuroendrocine regulation. There are two subtypes of the μ receptor, a high-affinity μ receptor and a low-affinity μ2 receptor. Recently a third μ subtype has been described that binds opioid alkaloids such as morphine, but has essentially no, or exceedingly low, affinity for the naturally occurring endogenous opioid peptides or non-alkaloid opioids such as fentanyl. Based on the hypothesis that mu (μ) opioid receptor expression increases at the site of inflammation. our study aims to assess the analgesic effect produced by local application of fentanyl through fentanyl soaked nasal packs following different nasal surgeries.
A carob flour (I) contg. at least 20% by dry wt. of tannins calculated as total polyphenols, the ratio of soluble tannins:insoluble tannins being below 0.37 (calculated in water at 37 deg.C) is prepd. by treating mature carob shells in water to extract most of the sugars and water-sol. tannins, sepg. the residue and drying below 100 deg.C. The dried residue is milled to a particle size below or equal to 200 micro metres. A dietetic prod. having a purifying and anti-diarrhetic action contains (I) as the active ingredient.
The invention relates to dental materials based on calcium phosphate glass ceramic materials with a shade of colour which is as far as possible similar to that of natural teeth. These dental materials based on calcium phosphate materials contain one, two or more type(s) of compounds as colouring components, selected from oxides of iron, manganese, cerium, titanium, nickel, zinc, cobalt, tungsten, chromium and vanadium. If necessary, Al2O3 and/or SiO2 are present in the material as colouring auxiliary. To improve the strength and toughness of the calcium phosphate glass ceramic materials, oxides of the rare earth metals are added. The calcium phosphate glass ceramic materials according to the invention consist of the same components as natural teeth. It is furthermore possible to suit their shade of colour exactly to the shade of colour of each individual tooth. In addition, the colouring components are incorporated in calcium phosphate crystals so that they are not leached out during use. The strength and the toughness of these materials are considerably improved compared with conventional calcium phosphate materials so that these materials are ideal dental materials.
Providers at facilities randomized to three-month ART dispensing will be expected to provide all enrolled patients with a 90-day supply of ART and associated HIV medications (cotrimoxazole and isoniazid if part of country guidelines). All other aspects of care will be as per standard of care for the enrolling clinic.
Juvederm Ultra 4® (by Allergan Co.) will be administered over a 2-week period (initial treatment plus one touch-up) to achieve optimal correction of the NLFs. In case of suboptimal correction of NLFs at week 2 after the initial treatment, the treating investigator will be directed to retreat the under corrected NLF(s).
AD-MIL is a manualized, 12-session individual psychotherapy designed to improve functioning and to reduce PTSD symptoms by facilitating Veterans doing corrective things in their life to heal and repair traumatic loss and moral injuries. The change agents are: (1) emotional-processing of traumatic loss and moral injuries and motivating a healing and action plan by writing therapeutic letters (e.g., to a lost unit member, to victims of personal transgressions, to people who transgressed); (2) skills training and behavioral contracting to improve functioning and targeting moral injury- and traumatic loss-related psychological and behavioral obstacles to positive and potentially habilitative engagements in occupational, relationship, and family roles; and (3) teaching self- and other-compassion and mindfulness. The goal is to redress the functional impact of moral emotions (anger, shame).
Objective: The preliminary results was reported regarding the treatment of mesenteric torsion by mesenteric fixation in the last decade, especially preventing recurrence of mesenteric torsion by mesenteric fan-shaped fixation. Methods: We selected 12 patients who received emergency operation in Chongqing Hospital of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from December 2010 to March 2022. All of them were made a definite diagnose of mesenteric torsion by the preoperative CT scan or exploratory laparotomy. The recurrence of mesenteric torsion will be prevented by taking the operation of mesenteric fan-shaped fixation. This technique is suitable for the patient who is suffering total mesenteric torsion, but enteric necrosis is excluded affirmatively. The operation is consists of the following progress: (1) Exploratory laparotomy to check for necrosis of the bowel and for lesions other than torsion. (2) Mesenteric torsion derotation.(3) Mesenteric linear fixation; the right posterior lower border of the small mesentery (terminal ileal mesentery) is intermittently sutured to the posterior peritoneum of the right lower quadrant to increase the width of the base of the small mesentery. (4) Mesenteric fan-shaped fixation, which is fan-shaped to the lower left and fixed in the posterior peritoneum, shortening the length of the mesentery and further increasing the width of the mesentery and posterior peritoneal fixation. Results: A total of 12 patients with mesenteric torsion were treated by operation for 15 times in all. Among them, 3 cases received resection of most small bowel were performed without recurrence; 3 patients received only derotation for a total of 4 times, 2 cases recurred, 1 of them recurred twice; 4 cases underwent derotation and mesenteric linear fixation,and 1 case recurred. Four patients with derotation and mesenteric fan-shaped fixation recovered well without recurrence. Conclusion: Mesenteric fan-shaped fixation may be an effective operative type to reduce or avoid postoperative recurrence of mesenteric torsion.
PURPOSE: A cosmetic composition for skin moisturization containing Cornus officinalis fermentation extract is provided to prevent dermatitis occurrence and to recover injured skin barrier function. CONSTITUTION: A cosmetic composition for skin moiturization contains Cormus officinalis fermentation extract as an active ingredient. A cosmetic composition for skin moisturization contains 0.0001-30 weight% of Cormus officinalis fermentation extract. The Cormus officinalis extract is obtained using water, alcohol, or ethyl ether. The Cormus officinalis extract fermentation is obtained by adding yeast and lactobaciilus to the Cormus officinalis extract, culturing and fermenting. The yeast is Saccharomyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., or Candida sp. The cosmetic composition is used in the form of skin ointment, skin, lotion, massage cream, essence, pack, emulsion, or oil gel.
The present invention relates to a medicine for treating hircismus, which is a hircus-treating medicament. The medicine for treating hircismus comprises traditional Chinese medicines including giant knotweed rhizome, dittany bark, lightyellow sophora root, rhizoma coptidis, Chinese angelica root and Chuanxiong rhizome, dried alum and scopolamine, borneol and hydrogen peroxide. Clinical treatment shows that the cure rate of the medicine for treating hircismus is 100% when the medicine for treating hircismus is taken for 5 to 10 days. The medicine for treating hircismus has no recurrence and has the effect on radical treatment. The medicine for treating hircismus thoroughly relieves the troubles of patients. The medicine for treating hircismus has the advantages of convenient use, high safety, no harmful effect on local skin elasticity or movable functions and no toxic or side effect.
Systems and methods for identifying variant alleles as somatic or germline are provided. Reference and variant alleles for a genomic position are identified. Methylation states and sequences of nucleic acid fragment sequences that map to the genomic position are obtained from a sample of a subject. Using the sequences of nucleic acid fragment sequences, each nucleic acid fragment sequence that has the reference allele is assigned to a reference subset, and each nucleic acid fragment sequence that has the variant allele is assigned to a variant subset. One or more indications of the methylation states across the nucleic acid fragment sequences in the variant subset and an indication of the number of nucleic acid fragment sequences in the reference subset versus the variant subset are applied to a trained binary classifier. An identification of the variant allele at the genomic position as somatic or germline is obtained from the classifier.
Participants will receive a high dose of BIIB080, IT injection, once on Day 1 and then Q12W for up to 72 weeks during the placebo-controlled period. Eligible participants will enter the LTE period, during which they will continue to receive BIIB080 high dose, IT injection, Q12W for an additional 96 weeks.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to oncology and neurology and can be applied in treatment of oncologic patients with accompanying Parkinson's disease. For this purpose before carrying out anti-tumour chemotherapy carried out is session of gravitation discrete plasmapheresis by apparatus MSC+"Haemonetics" in mode of plasma obtaining protocol, which is depleted of leucocytes, with speed of blood separation 4800 turns per minute, with volume of plasma extraction 800-1200 ml. As plasma-replacing solutions applied are Refortan 10%, Voluven 6%, Refortan 6% and crystalloid solutions: Disol, Chlosol, Reamberine. After that, carried out are two repeated sessions of plasmapheresis with interval 48-72 hours. During repeated hospitalisations of patients into the clinic with interval 2-3 months sessions of plasmapheresis are carried out in same mode. ^ EFFECT: method makes it possible to ensure possibility of carrying out chemotherapy for said category of patients in full volume. ^ 1 ex
Patients receive paclitaxel IV over 3 hours on day 1, cisplatin IV over 1 hour on day 2, and veliparib PO on days 1-7. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Insomnia is a sleep disorder characterized by a chronic difficulty in initiating and maintaining sleep which has a relatively high prevalence and a significant socioeconomic cost. There is good evidence that cognitive and/or physiological arousal, associated with sustained sympathetic activation, is one of the underlying causes of insomnia. Relaxation treatments such as progressive relaxation and meditation which address the cognitive and somatic arousal associated with insomnia have been found to be effective. Yoga is a comprehensive discipline which includes physical exercises, postures, breathing techniques, and meditation, for the purpose of improving health and well being. Research studies have documented the effectiveness of yoga in reducing sympathetic activation and cognitive and somatic arousal and in the treatment of specific medical disorders. Although it has been used and recommended for the treatment of insomnia, its effectiveness has not been evaluated in a randomized, controlled study. The aim of this proposal is to evaluate the effectiveness of yoga, relaxation exercises or sleep hygiene in the treatment of chronic psychophysiological insomnia. A subjective measure of sleep onset latency will be derived from daily sleep diaries, and an objective measure will be drawn from polysomnographic recordings. Sleep onset latency will be evaluated before and after a two month treatment period in a total of 48 young men and women who have been carefully screened for psychiatric and medical disorders. Subjects will be assigned to a yoga, relaxation exercise, or sleep hygiene treatment group. We anticipate that yoga practice will prove to be an effective treatment for insomnia which will yield significant improvements in sleep onset latency. We also anticipate that these improvements will be maintained at long-term follow up evaluation.
The method, object of the present invention, concerns the peracylation of oleuropein and its products of hydrolysis: The method makes use of the excellent properties as Lewis acid catalysts of halides and tryphilates of lanthanides (III). The component is placed to react, in the presence of catalytic quantities of Lewis acid, directly with an acylating agent containing at least one acylic group R, where R is H, an alkylic radical of 1-31 atoms of linear or branched carbon, an alkenylic radical containing up to 31 atoms of carbon or an arylic group. The procedures for the extraction and the successive hydrolysis of the oleuropein for the synthesis of its aglycon and the hydroxytyrosol, resolve the problems tied to the quantitative yield of the products and to the use of highly-toxic and expensive catalysts. Furthermore, the innovative and inventive contribution is given by the peracylation of the oleuropein and its products of synthesis, aglycon and hydroxytyrosol, that supply a new class of molecule, biologically active as anti-oxidants and anti-inflammatory ones. The proven anti-oxidant activity of oleuropein and its derivates leads to the hypothesis that they could also act as protectors against oxidative stress at the level of the central nervous system, one of the causal factors of Parkinson's disease. The molecules examined are all good protectors against oxidative stress and the greater efficiency of the peracylated derivatives is presumably due to their greater lipophilicity and the possibility of penetrating the cellular membrane.
An influenza Status Registry (ISR) that provides a method of acquiring, storing and displaying a person's status regarding influenza, particularly the COVID-19 coronavirus, as well as vaccination information. The ISR uses a software program that operates on a computer or a wireless device such as a smart phone or tablet computer. A person will have an influenza/COVID-19 test performed by a medical professional. The test results, which show the person's status, are then displayed on the computer or wireless device. Any business or other entity where multiple people congregate in a limited space then uses the ISR to determine if it is safe to allow each person to enter the location. The status will be displayed as never had, previously had or currently has influenza/COVID-19, and appropriate action can be taken based on the test results. Additionally, the ISR will display information pertaining to a person's vaccination status.
The invention discloses drug for treating leukemia. The drug is prepared by placing 15g of carbonized hair, 15g of Rheum officinale, 15g of Eupolyphaga sinensis, 15g of Semen persicae, 15g of almond, 15g of gadfly, 15g of hirudo, 15g of grub, 15g of raw licorice root, 15g of Radix paeoniae alba, 15g of Resina toxicodendri, 15g of Radix rehmanniae and 15g of Radix scutellariae at one position, and smashing the same into powder. An adult can take 6-8g of the drug each time, three times a day, dosage for children should be reduced by 2-3g, the drug can be taken after meals or taken with honey water or urine of healthy Baitongzi or urine of children who are under one year old and are breast-fed, and best treatment effect and highest curing speed can be realized if the drug is taken after meals or taken with honey water or urine of healthy Baitongzi or urine of children who are under one year old and are breast-fed. 7-10 days is taken to act, 28 days is taken to cure a patient with slight leukemia, and 60 days is taken to cure a patient with serious leukemia. The drug is free of toxic and side effect, quick to act after being taken and less prone to recurrence after leukemia is cured. When the drug is used to treat leukemia, effective rate is 100%, and curing rate is 95%. Notes: if full-power children's urine is used as a lead, curing rate needs to be advanced.