anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The complexes are stable is solid state. They are formed from SIN-1A and cyclodextrines or their derivatives, in a given case also containing ions as catalyst or stabilizer. The complexes release nitrogen oxide in dissolution in water or in aqueous systems at room temperature. Preferably the ions are anions of carboxylic acids such as acetate, fromiate, propionate, ascorbinate, tartarate and/or lactate and/or anions of inorganic acids such as borate, carbonate, hydrocarbonate, phosphate, phosphite, sulphate and/or sulphite and/or cations such as alkaline and/or amonium ones. The invention also relates to pharmaceutical compositions and sets containing the complexes. The sets can be used as standards for NO separation, NO being separated in a prespecified quantity and velocity of dissolution in aqueous medium. By the method, SIN-1 at suitabe pH is sibjected to catalytic effect of ions for displacing the equilibrium towards the formation of SIN-1A in the presence of cyclodextrine or its derivatives capable of being included in complexes. The SIN-1A formed is immediately bound in the complex, is stabilized and is isolated in solid state. By the method, SIN-1A and cyclodextrine or its derivatives react, in solid state, in the presence of salt as catalyst by complete mixing or grinding of the components or lyophilization of aqueous, oxygen-free, solutions containing them after which they are again vacuum dried.
Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Average and large doses of cortisone or hydrocortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Patients with a stressed myocardium should be observed carefully and the drug administered slowly since premature ventricular contractions may occur with rapid administration. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.

While on corticosteroid therapy patients should not be vaccinated against smallpox. Other immunization procedures should not be undertaken in patients who are on corticosteroids, especially in high doses, because of possible hazards of neurological complications and lack of antibody response.

The use of Dexamethasone Sodium Phosphate Injection in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate anti-tuberculosis regimen. 

If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

Because rare instances of anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any drug. 

Dexamethasone Sodium Phosphate Injection contains sodium sulfite, a sulfite that may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
The maintenance group will continue to perform the leg press three times per week at 1/3rd of final strength assessment. This is the percentage of intensity recommended to maintain muscle mass and strength gains by the American College of Sports Medicine.
The invention discloses a bacillus subtilis BSC16a and application thereof. The bacillus subtilis is preserved in the general microbiological culture collection center of China Committee for culture Collection of microorganisms in 2019, 9 and 6, and the preservation number is CGMCC NO: 18473. The strain has good in-vitro probiotic characteristics. The strain provided by the invention plays a good probiotic role in the aspects of improving the growth performance of the fattening pigs, improving the body immunity and reducing the intestinal pathogenic bacteria. In addition, the bacillus subtilis BSC16a is used as a probiotic preparation to feed diarrhea young animals, and the strain has good prevention and treatment effects on diarrhea livestock. The strain can also be used as a feed additive to be applied to the prevention and treatment of diarrhea of piglets, lambs and calves.
The apparatus comprises an implant (IP1), which is designed such that the data is stored in or on the implant. The implant comprises a memory unit (SM) for depositing the implant or patient data. An access code is stored in the memory unit, where the access code is a manufacturer-specific Internet address. The memory unit comprises a reading and writing unit. The memory unit is designed such that the design data and the three-dimensional implant model are deposited in it. An independent claim is included for a method for depositing implant data.
This randomized clinical trial alongside a cost-effectiveness analysis will include twenty-eight edentulous individuals who meet eligibility criteria. New maxillary and mandibular dentures will be fabricated for all participants following a standardized protocol. Then, participants will be randomized into one of the treatment groups: conventional complete denture group or single-implant mandibular overdenture group. Each participant allocated to the overdenture group will then receive a Straumann® Standard Plus SLActive® regular neck implant (Straumann 0.33.051S/052S/053S Institute Straumann AG, Basel, Switzerland) in the mandibular midline. A healing abutment will be connected and the implant will be allowed to heal for approximately 3 weeks. Then, a 3.4mm retentive titanium anchor abutment (Straumann 048.439, Institute Straumann AG, Basel, Switzerland) will be connected and tightened to 35 N.cm with a torque wrench. The matrix will be incorporated to the denture using self-curing acrylic resin and the patient will be instructed to keep the upper and lower dentures firmly occluded in the habitual position until the final polymerization of the resin. Direct costs related to therapies in both groups will be identified, measured and valuated for one year after treatment and patient-reported outcomes will be assessed. Incremental cost-effectiveness ratios will be estimated and graphically presented on cost-effectiveness planes. A Markov decision tree will be constructed to set out the consequences of the competing alternatives. Sensitivity analysis on the most important assumptions will be performed in order to assess the robustness of the model.
As part of a review of systems to screen for non-musculoskeletal low back pain, physical therapists perform an abdominal screening exam which may include observation and palpation of the abdominal aorta. Using a two-finger distance palpation method, an estimation of the abdominal aorta width is one screening approach. A growing part of physical therapy practice is use of point of care ultrasound imaging (POCUS) to guide a physical therapy diagnosis and assist with clinical reasoning. No published research could be found on physical therapists using diagnostic ultrasound imaging to measure the abdominal aorta distance, or intra-reliability in palpation of abdominal aorta transverse distance. A measurement in excess of 3 cm is typically characterized as an abdominal aortic aneurism. The goal of this study is to determine the reliability and agreement of abdominal aorta palpation measurements with transverse diameter abdominal aorta POCUS measurements performed by physical therapy researchers in healthy individuals. Healthy patients over the age of 18 without a history of abdominal aortic aneurisms will be recruited for a study with 2 visits within 1 month of each other at Mayo Clinic Rochester. Patients will undergo a brief survey of basic demographic information including age, sex, and race/ethnicity at first visit only. The patients will also have their height and weight taken by the examiners to determine BMI. The order of testing will be randomly allocated. Patients will lie supine in the hook-lying position with the abdomen exposed to the xiphoid process. Study Examiner 1 will take a two-finger palpation measurement of the abdominal aorta, just cranial to the umbilicus and caudal to the xyphoid using a tape measure. For the palpation measurement, the examiner will be blinded to the numerical measurement and another examiner will measure and record the distance. Study Examiner 2 will then perform transverse infra-renal \[above the umbilicus and slightly left\] abdominal aorta ultrasound using Vscan Air™ ultrasound imaging device. A short axis view of the abdominal aorta will be captured on screen with the borders of the aorta clearly outlined. Using digital calipers, the largest aorta diameter from outer lumen to outer lumen will be measured. Examiner 2 will be blinded to the actual ultrasound measurement, and the measurement will be read and recorded by another examiner. Subjects will return for a follow-up visit to repeat the above process within 1 month to capture intra-rater reliability.
Depression and alcohol use disorders contribute to a significant proportion of the burden of disease, in the United States and abroad. Patients who suffer from co-morbid depression and alcohol abuse/dependence have illnesses that are more severe, persistent and costly than people with either depression or an alcohol use disorder alone. The treatment of these patients remains controversial. Several studies have demonstrated that antidepressants can be safe and efficacious in the treatment of depression in people who continue to drink, and it is now considered the standard of care to provide such treatment. Other studies have shown that pharmacotherapy with naltrexone or acamprosate can help reduce drinking in alcoholics without co-morbid depression. A logical extension of these findings would be to study the treatment of depressed alcoholics with dual pharmacotherapy, combining an anti-depressant with a medication aimed at treating the alcohol use disorder. We will conduct a randomized, double-blind, placebo controlled trial of escitalopram plus acamprosate and behavioral treatment vs. escitalopram plus placebo and behavioral treatment in 20 depressed alcoholics. Outcome measures will include depression, alcohol use and global functioning.
The invention discloses microbial transglutaminase and rapid bleeding stopping products for traumatic blood loss in daily life. The products adopt mutant microbial transglutaminase as a main active substrate or an effective component. The raw material microbial transglutaminase used in the invention is a mutant enzyme obtained through gene mutation in the circumstance of not changing the functions and the original low toxicity of traditional microbial transglutaminase, wherein compared with wild type enzymes, the mutant enzyme has amino acid mutagenesis at 4 loci. The enzyme has the advantages of excellent heat resistance and good stability at normal temperature. The rapid bleeding stopping products for the traumatic blood loss in daily life, which are prepared through the mutant enzyme, comprise patches, creams (ointments and plasters), pastes and liniments. Proved by tests, the products disclosed by the invention have the effects of rapidly stopping bleeding, easing pain, preventing wound adhesion, blocking bacteria and the like and have the advantages of low toxic or side effects and convenience in use.
Those subjects who do not receive a meal and continue to fast. They only receive the vitamin D3 dose.
Fresh plants, such as mint, having constituents of therapeutic value are comminuted in admixture with lactose, e.g. in equal amounts, the pulp obtained being dried with moderately warm air of progressively diminishing humidity to a moisture content of less than 2 per cent by weight.  The temperature of the air should not exceed 30 DEG  C., and air at room temperature may be used.  The Specification as open to inspection under Sect. 91 comprises also the use of "non-crystalline" sugars such as d-mannose, of d-fructose, grape sugar, and invert sugar, or mixtures thereof with crystalline sugars which do not tend subsequently to crystallize, e.g. a mixture of cane sugar and starch sugar.  This subject-matter does not appear in the Specification as accepted.
Participants with chronic hepatitis C, who were under treatment with peg-interferon alfa-2a and ribavirin for four weeks, will be observed up to 24 weeks after end of treatment (EOT) (up to 72 weeks). Peg-interferon alfa-2a and ribavirin will be administered as per treating physician discretion and according to summary of product characteristics.
Groups receives treatment using sham cranial electrotherapy stimulation devices for 6 weeks. No actual treatment will be received. This group will not receive any treatment interventions. The same outcome measures will be used as the treatment group.
Participants will be treated with the SSRI Lexapro 10 mg daily which will be increased to 20 mg daily at week 2. Participants in this group will be treated twice weekly during their follow-up visits with micro-currents of electricity through auricular acupuncture.
BACKGROUND: Head and neck cancers (HNC) are associated with high rates of anxiety. Anxiety has been linked to biological pathways implicated in cancer progression, though little is known about its effects on overall survival. We hypothesized that higher pretreatment anxiety levels in patients with HNC would predict poorer 2-year overall survival and expected this relationship to be mediated by both systemic inflammation and tumor response to treatment.
METHODS: Patients (N = 394) reported anxiety symptomatology via the GAD-7 at treatment planning. Pre-treatment hematology workup provided an index of systemic inflammation (SII; N = 292). Clinical data review yielded tumor response and overall survival. Logistic and multiple regressions and Cox proportional hazard models tested hypothesized relationships.
RESULTS: Higher pretreatment anxiety levels were significantly associated with poorer 2-year survival (hazard ratio [HR], 1.039; 95% confidence interval [CI], 1.014-1.066, p = 0.002). The association between anxiety and SII was not significant, though anxiety was associated with poorer tumor response (odds ratio [OR], 1.033; 95% CI, 1.001-1.066, p = 0.043). Tumor response fully mediated the relationship between anxiety symptoms and 2-year survival (HR, 9.290, 95% CI, 6.152-14.031, p < 0.001).
CONCLUSIONS: Anxiety was associated with overall survival. Tumor response, but not systemic inflammation, emerged as a potential biological pathway mediating this effect. Screening for anxiety may be beneficial to help prospectively address these concerns and ameliorate potentially detrimental impact on clinically meaningful cancer outcomes.
PROBLEM TO BE SOLVED: To obtain a preparation for lightening skin color by using a specific compound which manifests more skin-lightening effect than that of hydroquinone and is readily available, thus having the action of inhibiting melanin formation and preventing the skin from staining, freckling and pigment sedimentation. SOLUTION: 2,4-Dihydroxybenzophenone is used as an active ingredient. The preparation for lightening skin color obtained according to this invention is used as a skin-lightening cosmetic. The amount of the active ingredient is 0.001-20.0wt.%, preferably 0.01-10.0wt.%, particularly 0.1-7.0wt.% based on the whole formulation in this preparation. 2,4-Dihydroxybenzophenone is obtained by, for example, the Friedel-Craft reaction between resorcin and benzoyl chloride or by the Fries rearrangement of monobenzoyl ester of resorcin. This skin lightening preparation is preferably formulated in cream, ointment, gel, lotion, milk, stick, pack or a solution in an organic solvent.
Cereal based snack bar with added plant stanol ester (0.8 g plant stanols/bar). Two bars consumed daily as a snack, between meals, for 4 weeks (1.6 g plant stanols/d).
193,024. Rahlejev, I. Feb. 11, 1922, [Convention date]. Lotions; ointments; toxins.-A lotion or ointment for external application for the treatment of rheumatism is prepared from ferments of saprophytic bacteria. In the method set forth, to obtain 100 grams of the lotion, the ferments of cultures of the bacteria (Subtilis, Oidium Albicans, and Staphylococcus) are sterilized in 0.5 per cent formalin and 25 grams of the preparation are mixed with a, second preparation. This second preparation contains 70 grams of a neutral oil such as sesame oil which with 0.3 per cent of ferric chloride is heated to ebullition and then cooled, mixed with 1.3 per cent of pure barium sulphate and again heated to ebullition, then again allowed to cool and to remain for 24 hours at ordinary temperature. The mixture is again heated to ebullition, gradually adding 1.27 per cent of lithium carbonate, and again cooled to ordinary temperature when a product obtained by warming 0.5 per cent of strontium nitrate with 5 grams of chloroform is added. The two preparations are then mixed and kept at a constant temperature for 48 hours. The lotion, which is stated to be of a bright yellow colour, may be coloured green with neutral chlorophyll. The Specification as open to inspection under Sect. 91 (3) (a.) states that as a preservative 0.02 grams of " carboxyl metalloids " are added. This subject-matter does not appear in the Specification as accepted.
A method for encapsulating non-polar compounds, such as steroids, terpenoids, and phytocannabinoids, at the micro, nano, and sub-nano scales. The invention involves a guest-host molecule formed of cyclodextrins crosslinked to form a dimerized, bridged, or polymerized encapsulating component. Crosslinking may be achieved using diacid linker molecules like succinic acid and tartaric acid. The resulting supramolecular encapsulating component exhibits improved complexation properties for a plurality of molecules of an ingestible item including, but not limited to, classes of polyphenols, terpenophenolics, phytocannabinoids, steroids, and flavonoids. These guest-host complexes may optionally be further enclosed within micro- and nano-capsules to enhance and prolong thermal stability. The stabilized active ingredients can be processed into a dry powder, which is highly suitable as a functional ingredient in pharmaceuticals, processed foods, culinary ingredients, and beverages.
There is only one arm of the study. All patients will undergo normal laparoscopy. After examining the abdominal structures for presence of endometriosis as well as performing photographic documentation, cystoscopy with intraureteral administration of ICG will be performed, after which intervention the ureters will be examined by laparoscopy. ICG is injected cystoscopy-guided into the ureters (cystoscopy-guided) in a dosage of 5 or 10ml (25mg ICG in 5 or 10ml NaCl) per ureter as a bolus injection.
BACKGROUND: Weight-loss approaches involving mindfulness have been reported to reduce overeating behavior. We conducted a preliminary evaluation of the feasibility and effectiveness of a mindfulness mobile application (MMA) combined with a comprehensive lifestyle intervention (CLI) focused on weight loss and eating behaviors for people with metabolic syndrome based on post-intervention follow-up data.
METHOD: Participants were randomly assigned (1:1) to a CLI group or a CLI + MMA group. Participants received weekly CLI for 13 weeks, followed by telephone counseling for 13 weeks. The CLI + MMA group also had access to the MMA. Feasibility was assessed by the number of people who refused to participate, rate of adherence to the MMA, follow-up rate, and participant satisfaction. The preliminary endpoint was weight change (at 26 weeks). Participants completed the Dutch Eating Behavior Questionnaire (DEBQ). A mixed linear model was used for efficacy analysis.
RESULTS: Eight of the 40 participants declined to participate. The MMA was used 4.4 ± 1.7 days per week, but the rate of adherence declined over time. The follow-up rate was 100%, and there was no difference in participant satisfaction between the groups. There was no significant group-by-time interaction for weight loss (p = 0.924), but there was a significant interaction for the DEBQ restrained eating score (p = 0.033).
CONCLUSIONS: This study found that CLI plus MMA was highly feasible and moderately acceptable. There were no significant differences in weight loss between the groups, but the CLI + MMA group showed an increase in restrained eating. Further large-scale studies are needed.
TRIAL REGISTRATION: Japanese University Hospital Medical Information Network (UMIN-ICDR). Clinical Trial identifier number UMIN000042626.
A novel product for headache relief and use of the product to treat headaches is disclosed herein. The product may be applied topically, and may be used for acute treatment of headaches to provide a safe, effective, and natural alternative to traditional therapies used to treat acute headache syndromes. The product comprises one or more herbal therapeutic agents. In some embodiments, the one or more herbal therapeutic agents may be combined with allopathic or other traditional headache therapies. In preferred embodiments, the product is applied to select myofascial trigger points. (MTPs) on the temporal, frontal, mastoid, and cervical regions. The product may be available over-the-counter or otherwise may be available without a physician's prescription.
Hawthorns have a long health care and medicinal history in China. The hawthorn fruits are rich in total flavonoids. The total flavonoids have various pharmacological and health care functions of reducing blood pressure and blood fat and resisting tumors, diabetes mellitus and complications thereof. Cell walls of plants are mainly formed by cellulose, hemicellulose and pectin substances. Cellulase and pectinase are utilized to act on the hawthorn fruits and the cell walls treated by the two composite enzymes are broken through hydrolyzing, thus being beneficial to dissolution of flavonoid compounds in the cells. Ultrasonic vibration can lead to motion of substances in the cells to enable the cytoplasm to flow and the cells to shake, thus thinning the cell walls. Ultrasonic vibration is beneficial to interinfiltration in solvents and plant cells, thus increasing dissolution of active ingredients in the solvents. Therefore, by combining the composite enzymatic hydrolysis method and the ultrasonic extraction method, the advantages of the two methods can complement each other and more flavonoid substances in the hawthorns can be extracted under the moderate and controllable conditions.