anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
ERP will be based upon the Treatments That Work series, which contains both a provider manual and client workbook. Sessions will last 90 minutes and occur weekly for 16 sessions. All ERP treatment will be delivered via VTH. Participants will receive instructions on accessing the VTH platform and take part in a brief practice run connecting to the VTH appointment with guidance from an RA. ERP treatment content includes psychoeducation about OCD, assessment of OCD symptoms, the rationale for treatment, construction of a hierarchy or a list of feared or avoided situations, and in-session in-vivo and imaginal exposures. Weekly homework assignments will include self-monitoring, reading chapters about the treatment, and practicing exposures daily. All therapy sessions will be audio-recorded. Although sessions are expected to occur weekly, accounting for delays due to scheduling, holidays, and missed appointments, the investigators will allow up to 6 months to complete the treatment.
The misuse of antibiotics has led to the global spread of drug-resistant bacteria, especially multi-drug-resistant (MDR) ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). These opportunistic bacteria pose a significant threat, in particular within hospitals, where they cause nosocomial infections, leading to substantial morbidity and mortality. To comprehensively explore ESKAPE pathogenesis, virulence, host immune response, diagnostics, and therapeutics, researchers increasingly rely on necessitate suitable animal infection models. However, no single model can fully replicate all aspects of infectious diseases. Notably when studying opportunistic pathogens in immunocompetent hosts, rapid clearance by the host immune system can limit the expression of characteristic disease symptoms. In this study, we examine the critical role of animal infection models in understanding ESKAPE pathogens, addressing limitations and research gaps. We discuss applications and highlight key considerations for effective models. Thoughtful decisions on disease replication, parameter monitoring, and data collection are crucial for model reliability. By meticulously replicating human diseases and addressing limitations, researchers maximize the potential of animal infection models. This aids in targeted therapeutic development, bridges knowledge gaps, and helps combat MDR ESKAPE pathogens, safeguarding public health.
Novel prepreg of a glass fiber cloth(FEC) is produced by(1) heat treating the inner portions of the selvage of a GFC for removing the residual stress of the glassfiber in the GFC, (2) coating the selvage with a soln. of a satd. polyester resin type softening at 150-180deg. C and unsoluble in a thermosetting resin varnish, selvage contains 4- 10 wt. % resin, (3) drying the GFC and cutting off, and (4) impregnating with a thermosetting resin varnish and drying the impregnated GFC.  The thermosetting resin is an epoxy or polyimide resin for drying laminating method.
OBJECTIVE: We analyzed the incidence and mortality rate of gastrointestinal (GI) tract perforation after radiofrequency ablation (RFA) for hepatic tumors and assess its risk factors.
METHODS: This retrospective cohort study included 4799 patients with malignant tumors who underwent RFA (n = 7206). Sixty-nine cases of thermal injury to the GI tract were identified via a search of the electronic medical record system using index terms and divided into two groups according to the thermal injury with (n = 8) or without (n = 61) GI tract perforation based on follow-up CT reports. The risk factors for GI tract perforation were identified via multivariable logistic regression analysis using clinical, technical, and follow-up CT findings.
RESULTS: The incidence of thermal injury to the GI tract and GI tract perforation was 0.96 % (69/7206) and 0.11 % (8/7206), respectively. The type of adjacent GI tract and history of diabetes mellitus differed significantly between the two groups (p < 0.05). The index tumor being located around the small intestine was the only significant risk factor for GI tract perforation after ablation (Odds ratio, 22.69; 95 % confidence interval, 2.59-198.34; p = 0.005 [reference standard, stomach]). All perforations were not identified on CT images immediately after RFA. The median time to detection was 20 days (range, 3-41 days). Two patients (25 %, 2/8) died due to perforation-related complications.
CONCLUSION: GI tract perforation after RFA for hepatic tumors is rare; however, it is associated with high mortality. Thus, careful follow-up is required after RFA if the index tumor is located around the small intestine.
The L'DISQ (U\&I Co., Uijeongbu, Korea) is one of the minimally invasive disc decompression procedures which was introduced in 2011. The L'DISQ uses a navigable tip and flexible handle allowing resection of the posterolateral or posterior median disc tissue without thermal damage.
Obstructive sleep apnea (OSA) has long been studied in patients with obesity and type 2 diabetes mellitus (T2DM), due to the fact that both disorders are commonly associated with an increased body mass index (BMI). However, a link between OSA and non-obese diabetic patients is still not very elaborated, nor heavily explored. In this review, we elucidate some proposed mechanisms for the link between OSA and diabetic patients both with and beyond obesity, shedding the light on the latter case. One such mechanism is oxidative stress, a phenomenon of reactive oxygen species (ROS) imbalance seen in both of the previously mentioned disorders. A plausible explanation for the OSA-induced ROS production is the repeating episodes of hypoxia and reperfusion and their effect on the mitochondrial electron transport chain. This paper explores the literature regarding ROS imbalance as the possible missing link between OSA and Diabetes Mellitus beyond obesity, while still mentioning other possible proposed mechanisms such as a dysregulated autonomic nervous system (ANS), as well as mechanical and craniofacial abnormalities. This paper also suggests a link between OSA and diabetic complications, while exploring the clinical progress made in treating the former disorder with anti-oxidant and hypo-glycemic drugs. If further investigated, these findings could help identify novel therapeutic interventions for the treatment of OSA and Diabetic patients.
Additional (expansion of) participants will dose with 2000 mg daily oral PC14586 (INN: rezatapopt) with food for continued evaluation. Ovarian Cancer Cohort participants will have locally advanced or metastatic ovarian cancer harboring a TP53 Y220C mutation who meet all eligibility criteria and have measurable disease per RECIST 1.1.
PURPOSE:To obtain an aerosol composition which is capable of stably producing a mist and does not cause an environmental pollution by incorporating dimethyl ether and a compressed gas having a specific critical temp. into a base liquid comprising an active ingredient and water. CONSTITUTION:A base liquid comprising water and an active ingredient, e.g. a fixative polymer, a fragrance-emitting substance, or a detergent and optionally containing a 1-6C alcohol (e.g. ethyl alcohol), a surfactant (e.g. a polyoxyethylene sorbitan fatty acid ester), etc., is mixed with dimethyl ether and a compressed gas having a critical temp. of -20 deg.C or higher (e.g. carbon dioxide) to produce the objective aerosol composition. Since this composition consists mainly of substances which are harmless or less harmful to the earth, it is excellent from the standpoint of environmental protection. Further, since it undergoes little decrease in pressure with use, mist droplets never become coarse until the composition is used up.
PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an ACC activity inhibitor (ACC: Acetyl-CoA Carboxylase) effective for the treatment of viseral adiposis syndrome as a risk factor of geriatric diseases such as myocardial infarction, cerebral infarction and diabetes. SOLUTION: This new compound is a butanoic acid amide derivative of formula I (R<1> and R<2> are each a 1-6C alkyl, aromatic hydrocarbon group, aromatic heterocyclic group or the like; R<3> is an acidic functional group; ring A is an aromatic hydrocarbon group, aromatic heterocyclic group or cyclic alkyl), e.g. 1-(2,4-dibenzyloxy-3,3-dimethylbutyrylamino)-1-cyclohexanecarboxylic acid. The derivative of formula I is obtained, for example, by condensation reaction between an amino compound of formula II and a carboxylic acid compound of formula III pref. in equimolar amounts in the presence of a condensation agent pref. at 0 deg.C to the about boiling point of the solvent to be used for about 0.1-25 h.
Detecting and identifying child abuse and neglect is quite challenging and relies heavily on the knowledge and skills of healthcare professionals (Child Welfare Information Gateway, 2019). In a hospital setting, healthcare professionals frequently encounter children who have experienced abuse and/or neglect. Nurses, who are often the first to interact with the child and their family, play a crucial role starting from the process of taking the medical history to provide care and treatment (Chen et al., 2022). Nurses who have frequent contact with children and their families are in a good position to protect children from abuse and neglect (Bahrami et al., 2021). Particularly in emergency departments, nurses often come across child abuse and neglect, including various types such as Munchausen by Proxy Syndrome, which is a form of physical abuse (Chen et al., 2022). Therefore, it is crucial, especially for nurses, to carefully observe children who may be victims of abuse and evaluate all children who come to the hospital for signs of abuse and neglect (Başdaş \& Bozdağ, 2018). Nurses need to have sufficient knowledge and skills regarding child abuse and neglect to accurately identify cases and provide appropriate care (Jordan \& Moore-Nadler, 2014). They should establish communication with the child and their family, attempt to recognize the signs and symptoms of abuse and neglect, and report the case from a forensic perspective (Chen et al., 2022). To fulfill these roles and responsibilities adequately, nurses need to receive education on child abuse and neglect (Topçu et al., 2022). Insufficient education on child abuse and neglect, as well as inadequate research on the subject, can lead to a lack of knowledge and cases being overlooked. For example, in Turkey, there are only a limited number of universities offering elective courses on child abuse and neglect within nursing curricula (Topçu et al., 2022). Similarly, a limited number of studies have shown that the level of awareness regarding child abuse and neglect is good when it is included in the pediatric nursing curriculum (Özçevik et al., 2018). However, studies conducted in Turkey involving nurses (Başdaş \& Bozdağ, 2018; Burç \& Güdücü Tüfekci, 2015) and particularly nursing students (Erkut et al., 2021; Ozbey et al., 2018; Seferoğlu et al., 2019; Tek \& Karataş, 2021) have revealed that their knowledge levels regarding child abuse and neglect are insufficient, similar to countries like India (Poreddi et al., 2016). In order to identify cases of child abuse and neglect, it is essential for nurses, especially before entering the profession, to have sufficient knowledge about the signs and risks of child abuse and neglect. It has been emphasized that nursing students need to learn their legal responsibilities and receive education to enhance their knowledge and become more competent (Akcan \& Demiralay, 2016; Bağ \& Bozkurt, 2021; Kuşlu \& Bulut, 2021; Seferoğlu et al., 2019).
Cardiac thromboembolism attributed to atrial fibrillation (AF) constitutes at least one-third of ischemic strokes.The prevalence is projected to increase 20% the coming decades, especially in age group 65 years and above of age. To add to incidence, the diabetic population have an increased risk yet not properly investigated. In patients with confirmed AF, assessment using the CHA2DS2-VASc score (congestive heart failure, hypertension, age 65 years and above, diabetes mellitus, stroke, vascular disease, age 75 years and above, sexual category) , is applied for risk stratification. If the CHA2DS2-VASc score is at least 1, or definitely 2 points typically a Non-vitamin K antagonist Oral AntiCoagulants (NOAC) should be prescribed. The chest- and thumb-electrocardiogram (ECG) system Coala Heart Monitor will be used to detect AF, which showed to be feasible from a patient perspective. Thus, in patients aged 65 years and above with diabetes mellitus at least 2 points are reached. Therefore, patient with these risk factors should be considered for further evaluation for NOAC to prevent stroke, which provides the rational for this study.
E6007 50mg or E6007 matching placebo x 2, orally once daily in the morning under fasted condition. Drug administration on 1 day for single dose period (Day 1) and 7 days (Day 5 to 11) for repeated dose period.
In 2011, the United Nations defined happiness as a "fundamental human goal" and invited Member States to pursue measures that enhance the happiness of their citizens. The majority of people across the globe agree that happiness is an important goal. In accordance with this global goal to be happy, the psychological literature abounds with interventions to combat problems that may prevent people from being happy-from obesity to depression and physical pain. However, happiness is not simply the absence of problems. Yet, interventions to help people attain and maintain higher levels of happiness are rare. Accordingly, in a previous study, the investigators designed and evaluated the efficacy of a theoretically-grounded, evidence-based randomized controlled trial for enhancing happiness and well-being. In the present study, it is the goal to assess the efficacy of modifications made to the original program, and compare the program to a self-help comparison group. All participants in the study will complete weekly questionnaires, as well as the same battery of online assessments at baseline, the end of the study, and 3-months following the study. The investigators will be examining if changes seen from baseline to the end of the interventions are maintained through a maintenance intervention in both arms for 3 months following the primary intervention.

It is expect that participants actively completing the in-person ENHANCE program will report greater increase in their overall levels of happiness/well-being at the end of the 12-week program compared to participants in the MBSR self-help group. It is predicted that there will be a downstream effect on happiness for all participants' mental and physical health, cognitive function, social relationships, and other positive outcomes, but that this effect will be greater for participants in the active in-person ENHANCE group. The insights gained from this research could be used in future intervention research towards promoting health, achievement, citizenship, and better relationships.
Cyclopropane or halogenated hydrocarbon anesthetics increase cardiac autonomic irritability and may sensitize the myocardium to the action of certain intravenously administered catecholamines, such as dopamine. This interaction appears to be related both to pressor activity and to the beta-adrenergic stimulating properties of these catecholamines, and may produce ventricular arrhythmias. Therefore, EXTREME CAUTION should be exercised when administering dopamine HCl to patients receiving cyclopropane or halogenated hydrocarbon anesthetics. Results of studies in animals indicate that dopamine-induced ventricular arrhythmias during anesthesia can be reversed by propranolol.

Because dopamine is metabolized by monoamine oxidase (MAO), inhibition of this enzyme prolongs and potentiates the effect of dopamine. Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine should receive initial doses of dopamine hydrochloride no greater than one-tenth (1/10) of the usual dose.

Concurrent administration of low-dose dopamine HCl and diuretic agents may produce an additive or potentiating effect on urine flow.

Tricyclic antidepressants may potentiate the cardiovascular effects of adrenergic agents.

Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents, such as propranolol and metoprolol. The peripheral vasoconstriction caused by high doses of dopamine HCl is antagonized by alpha-adrenergic blocking agents. Dopamine-induced renal and mesenteric vasodilation is not antagonized by either alpha- or beta-adrenergic blocking agents.

Butyrophenones (such as haloperidol) and phenothiazines can suppress the dopaminergic renal and mesenteric vasodilation induced with low-dose dopamine infusion.

The concomitant use of vasopressors, vasoconstrictor agents (such as ergonovine) and some oxytocic drugs may result in severe hypertension.

Administration of phenytoin to patients receiving dopamine HCl has been reported to lead to hypotension and bradycardia. It is suggested that in patients receiving dopamine HCl, alternatives to phenytoin should be considered if anticonvulsant therapy is needed.
Methods, systems, and devices for analyzing objective health data and subject-conveyed health information are disclosed for health information reporting, treatment planning, diagnoses, and treatment. According to an aspect, a method can include receiving objective health data of a subject. Further, the method can include receiving a first set of information about the subject's health. The first set of information was conveyed by the subject. The method includes presenting the objective health data to the subject. The method includes receiving, subsequent to presentation of the objective health data to the subject, a second set of information about the subject's health, wherein the second set of information was conveyed by the subject. The method can also include analyzing the objective health data, the first set of information, and the second set of information. Further, the method can include determining a treatment plan, diagnosis, and/or health information based on the analysis.
Type 2 diabetes affects over 29 million US adults, with a disproportionate burden of disease borne by low-income populations. Effective self-management requires attention, planning, follow-through and consistent performance of multiple health behaviors to prevent negative health outcomes. For low-income individuals, though, health improvement is often superseded by the drive to fulfill basic needs such as food, housing, personal safety, and money for necessities. Having unmet basic needs can overwhelm a person's ability to maintain health behaviors. Prior research has demonstrated that with more unmet basic needs, low-income individuals are less likely to even remember or act on a referral for needed health services. However, when unmet needs are resolved and/or people have a personal navigator to help, the likelihood of acting on a health referral significantly increases. Traditionally, patient navigators help coordinate care, manage disease or promote screening and preventive behaviors. This study will expand the role of navigators to include identifying and resolving unmet basic needs, which is expected to facilitate behavior change and improve health outcomes. This approach will be tested in a pragmatic randomized trial conducted in partnership with Louisiana Healthcare Connections, the largest Medicaid managed care plan in Louisiana. This study will test the effectiveness of a basic needs navigation intervention compared to usual care among 500 adults (ages 18-75) with Medicaid, type 2 diabetes, and 1 or more unmet basic needs. The primary hypothesis is that intervention participants will have a greater reduction (M=0.5%) in HbA1c pre-post compared with usual care participants. Consistent with the study's conceptual model, the effects of unmet basic needs on barriers to self-care (e.g., attention, stress, sleep), health behaviors (e.g., glucose monitoring, diet, clinical screenings) and health outcomes (e.g., emergency department utilization, hospitalization, quality of life) will be examined. Louisiana Healthcare Connections will identify eligible members for study recruitment and provide basic needs navigation for 6 months. The research team will recruit, enroll, randomize, and survey study participants by phone at baseline and 3-, 6- and 12-month follow up. HbA1c data will be obtained from electronic medical records to assess change.
The application discloses apparatuses, systems and methods for selecting a base data entry for distribution with a content provider's requested content. More specifically, the disclosed system may be configured to receive and process a distribution advertisement request from a content provider or an affiliate. The system processes the advertisement request to extract content provider distribution parameters and/or web user data characteristics, if they exist. This data may be processed to create an initial a pool of potential base data entries, one (or more) of which will be distributed to a content provider. In an implementation, the system further processes the initial pool based on sponsor distribution parameters associated with the various base data entries that comprise the pool. Based on this analysis, the system selects one or more of the potential base data entries based on a variety of ad distribution considerations.
Premature Closure of Fetal Ductus Arteriosus

Avoid use of NSAIDs, including SEGLENTIS, in pregnant women at about 30 weeks gestation and later. NSAIDs, including SEGLENTIS, increase the risk of premature closure of the fetal ductus arteriosus at approximately this gestational age.

Oligohydramnios/Neonatal Renal Impairment

Use of NSAIDs, including SEGLENTIS, at about 20 weeks gestation or later in pregnancy may cause fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. Oligohydramnios is often, but not always, reversible with treatment discontinuation. Complications of prolonged oligohydramnios may, for example, include limb contractures and delayed lung maturation. In some postmarketing cases of impaired neonatal renal function, invasive procedures such as exchange transfusion or dialysis were required.

If NSAID treatment is necessary between about 20 weeks and 30 weeks gestation, limit SEGLENTIS use to the lowest effective dose and shortest duration possible. Consider ultrasound monitoring of amniotic fluid if SEGLENTIS treatment extends beyond 48 hours. Discontinue SEGLENTIS if oligohydramnios occurs and follow up according to clinical practice [see Use in Specific Populations (8.1)].
T1DM Group - 150 otherwise healthy children, ages 4-16 years old, diagnosed with T1DM within 3 months prior to their initial study visit. This is not a treatment study therefore there is no intervention in this study.