anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to the field of traditional Chinese medicine preparations and particularly relates to a traditional Chinese medicine composition for treating burns and scalds. The traditional Chinese medicine composition is composed of the following components in parts by weight: 10-15 parts of coptis chinensis, 5-15 parts of radix sanguisorbae, 5-15 parts of radix rehmanniae, 10-15 parts of angelica sinensis, 5-15 parts of rheum officinale, 1-3 parts of musk, 2-5 parts of borneol, 40-60 parts of beewax and 200-300 parts of sesame oil. The traditional Chinese medicine composition for treating burns and scalds is prepared according to the theory of traditional Chinese medicines. All the traditional Chinese medicines are combined and are mutually supplemented to take the curative effect of rapidly healing wounds of burns and scalds of skins; the traditional Chinese medicine preparation is low in toxic or side effect and capable of directly acting on the wounds and treating both symptoms and root causes. The traditional Chinese medicine composition disclosed by the invention has the advantages of softness, lubrication as well as no hardening and bonding discomfort. A layer of film is formed after the traditional Chinese medicine composition rapidly covers an injured wound, so that the seeped intracellular fluid of injured cells is effectively reduced, and the infection opportunity of exogenous bacteria is reduced. Meanwhile, the body movement of a patient is not influenced.
Goal will be to attain 15% of daily calories from saturated fat. Decrease intake of monounsaturated fat.
The Control Arm (CA) were followed up as usual every 6 months in outpatient vascular visits in the clinical hospital. If some patient have a complications or and emergency they have to do usual protocol, go to primary care or emergency.
The research was conducted as a randomized controlled trial. The stratified and permutation block randomization methods were used in the study. The personal information form and BSES-SF were administered to women in the hospital before the intervention. Breastfeeding education and counseling were provided via social media (WhatsApp) to support women for breastfeeding and to ensure the continuity of breastfeeding in the postpartum period. Breastfeeding education was given to women in the first four weeks after discharge from the hospital. The control group received the routine breastfeeding postpartum educational training given to all women by healthcare personnel as part of the hospital procedures. Except for routine breastfeeding training, no intervention was applied to the control group.
FIELD: medicine, pharmaceutical industry, pharmacy. SUBSTANCE: invention relates to development of immunomodulator of vegetable origin as cocktail. Invention proposes immunomodulator consisting of licorice root viscous extract and dispersion medium as distilled water and nitrous oxide taken in the volume ratio = (1:10)-(1:15), respectively. The proposed cocktail exhibits double (immunomodulating effect): stimulating effect on the level of antibodyforming cells in spleen and suppressive effect on E-rosette-forming cells in spleen. EFFECT: valuable properties of agent. 2 tbl
BACKGROUND: Pudendal neuralgia is a chronic and debilitating condition. Its prevalence ranges from 5 to 26%. Currently, therapeutic approaches to treat pudendal neuralgia include patient education, medication management, psychological and physical therapy, and procedural interventions, such as nerve block, trigger point injections, and surgery. Drug therapy has a limited effect on pain relief. A pudendal nerve block may cause a significant decrease in pain scores for a short time; however, its efficacy significantly decreases over time. In contrast, pudendal nerve pulsed radiofrequency can provide pain relief for 3 months, and ganglion impar block has been widely used for treating chronic perineal pain and chronic coccygodynia. This study aimed to determine the efficacy and safety of monotherapy (pudendal nerve pulsed radiofrequency) and combination therapy (pudendal nerve pulsed radiofrequency plus ganglion impar block) in patients with pudendal neuralgia.
METHODS: This randomized, controlled clinical trial will include 84 patients with pudendal neuralgia who failed to respond to drug or physical therapy. Patients will be randomly assigned into one of the two groups: mono or combined treatment groups. The primary outcome will be a change in pain intensity measured using the visual analog scale. The secondary outcomes will include a Self-Rating Anxiety Scale score, Self-Rating Depression Scale score, the use of oral analgesics, the Medical Outcomes Study Health Survey Short Form-36 Item score, and the occurrence of adverse effects. The study results will be analyzed using intention-to-treat and per-protocol analyses. Primary and secondary outcomes will be evaluated between the mono and combined treatment groups. Subgroup analyses will be conducted based on the initial ailment, age, and baseline pain intensity. The safety of the treatment will be assessed by monitoring adverse events, which will be compared between the two groups.
DISCUSSION: This study protocol describes a randomized, controlled clinical trial to determine the efficacy and safety of mono and combination therapies in patients with pudendal neuralgia. The study results will provide valuable information on the potential benefits of this combination therapy and contribute to the development of more effective and safer treatments for patients with pudendal neuralgia.
TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR2200061800).
Flexibility is regarded as a crucial component of typical biomechanical operation. A tight hamstring increases the risk of frequent impairment to the associated musculature and bony structure. Hamstring muscles are associated with lumbar spine, pelvic and lower limb movement disorders and have been connected to low back discomfort and abnormal gait pattern. It has been observed that long sitting and sedentary life style is directly related to reduce the hamstrings flexibility, so the persons with tight hamstrings are more prone to develop musculoskeletal disorders if not addressed properly. Previous research has shown that contract relaxation and Mulligan's bent leg are both useful for increasing hamstring flexibility. But there hasn't been much research comparing the two methods, Mulligan bent leg lift and contract relax, for hamstring muscle stiffness in middle age office employees; instead, it was done in young people and athletes. Hence, the aim of present work is to study and compare the effectiveness of contract relax and Mulligan bent leg raise in middle age office workers with long sitting hours having hamstring tightness
Cervical spondylosis is a chronic degenerative process of the cervical spine which affects the vertebral bodies and intervertebral discs and causes herniated intervertebral discs, osteophytes, and ligament hypertrophy. It is commonly seen in patients between the ages of 40 and 60. Neck pain not only imposes a notable burden on individuals in the society, but also affects families, the healthcare and economic systems of countries. In 2017, age-standardized prevalence, annual incidence, and years lived with disability from neck pain were estimated at 3551, 807, and 352 per 100,000 population worldwide, respectively Patients seeking medical help for this condition primarily complain of neck pain and/or stiffness. This pain is considered the second most common complaint post low back pain and increased by neck movements especially hyperextension and side bending Currently, there are several therapeutic approaches, either pain relievers or non-medicinal treatments for the management of cervical spondylosis and its associated pain and disability Pain medications mainly include non-steroids anti-inflammatory drugs and narcotics with exercise therapy, massage, physiotherapy, and local injections are among the most common non-medicinal therapies. Evidence suggests that exercise therapy plays a role in improving neck pain and disability of patients with cervical spondylosis. Besides, thanks to being non-invasive and profitable, exercise therapy is commonly used in patient rehabilitation Therapeutic exercises include various workouts such as proprioceptive exercises, stability exercises, strength exercises (dynamic and isometric) and endurance exercises. Neck retraction helps recover the lordotic curve in the lower cervical portion, but kyphotic changes may occur at the upper cervical level. The motor control exercises are the therapeutic approach which mainly focuses on motor control, activation of deep cervical muscles, and aims to retrain the optimal control and coordination of the cervical muscles Apart from the fact that clinical guidelines suggest therapeutic exercises as an integral part of managing neck pain and disability, prescribing the most advantageous exercise therapy has yet been controversial and even current guidelines do not offer specific recommendations on the preferred type and dosage of exercises
The modulation of inflammation is effective to treat many ocular surface diseases. Thus the low bioavailability of common anti-inflammatory eye-drops urges the development of ocular drug delivery systems to extend the ocular retention and enhance the cellular uptake for improving anti-inflammatory effect of eye-drops. Here we covalently conjugate two molecules of clinically anti-inflammatory drug (i.e., dexamethasone) with a small peptide (i.e., Tyr-Glu-Asn-Pro-Thr-Tyr) to generate an anti-inflammatory hydrogel eye-drop. With a self-assembled ability, the designed supramolecular hydrogel achieves gel-sol-gel transition by varying shearing forces which increases the pre-corneal retention of drug. The fluorescent imaging reveals the efficient cellular uptake of designed conjugate via clathrin-mediated endocytosis. A rodent model of endotoxin-induced uveitis verifies that the supramolecular hydrogel eye-drop suppresses inflammation responses without ocular irritation. As a rational approach to design anti-inflammatory drugs as eye-drops, this work overcomes the frequent instillation of clinical eye-drops and further improves the bioavailability of anti-inflammatory drugs, which may provide an effective and household way to fight ocular surface inflammation.
System for the treatment of pathological symptoms of the inner ear and labyrinth comprises a periauricular topical carrier system with a therapeutic dose of a local anaesthetic applied periauricularly to the intact skin, so that the local anaesthetic is released from the carrier into the periauricular region of the skin. The local anaesthetic is pref. an amide or ester, esp. lidocaine tetracaine, prilocaine, bupivacaine, mepivacaine, procaine or benzocaine (concn. 0.5-40%). The system is in a form that is made to suit the morphology and anatomy of the periauricular application field, esp. round, oval, angular or half moon shaped; with concave or convex outer shape; or segmented. The system may contain another local anaesthetic, with the total concn. of the two local anaesthetics not more than 40%.
AIM: The current study aims at describing sexually transmitted infections (STI) surveillance data collected from 2015 to 2020 as well as investigating patients' characteristics and risk factors in the sample population.
BACKGROUND: Reported STI cases are continuously increasing in Europe. In Belgium, 94.1% of citizens have a regular general practitioner (GP) or are affiliated to a general practice. By using GPs for surveillance, STIs can be monitored in the general population. Between January 2015 and December 2020, the Sentinel General Practitioners (SGP) network retrospectively reported five STIs: chlamydia, gonorrhoea, genital warts, herpes, and syphilis.
METHODS: In the SGP network database on STIs, participating GPs report on case-by-case basis through paper or online registration forms. We performed descriptive statistics, X2 test and logistic regression using SAS® 9.4. Multivariate multiple logistic regression was performed to investigate the relationship between STIs and patients' characteristics.
FINDINGS: During the study period, 1009 cases were reported, corresponding to an episode-based incidence estimated at 121 per 100,000 inhabitants. The majority of patients (59.8%) were men, and 83.6% were under age 30. Among female patients 92.7% had heterosexual contacts whereas 64.4% of male patients did. Women were more likely to be diagnosed with chlamydia (odds ratio [OR] 1.56; 95% confidence interval [CI] 1.12-2.17) and herpes (OR 1.72, 95% CI 1.04-2.86) than men.In this study, STI surveillance data were in agreement with literature. Continuous surveillance through the SGP network remains an important tool to obtain information about populations at risk and STI incidence in the general population.
PURPOSE:To provide a new compound useful as a cancer proliferation suppressing agent and cancer metastasis suppressing agent. CONSTITUTION:The compound of formula I or formula II ((m) is 7 or 8) and its pharmacologically permissible salt, e.g. (S)-2,3-dihydrosolanesol. The compound of formula I can be produced e.g. by carrying out the asymmetric reduction of the double bond at the 2-site of a compound of formula III in a solvent in the presence of an asymmetric ruthenium-phosphine complex catalyst in hydrogen gas flow preferably at room temperature. The compound of formula II is produced by converting the compound of formula I into phosphoric acid ester.
PURPOSE: A composition containing garlic extract for anti-aging is provided to highly suppressing aging in skin cells. CONSTITUTION: A composition for skin anti-aging contains garlic extract as an active ingredient. The garlic extract is isolated using water, low alcohol of C1-C4, or their mixture solvent. The extract is an extract, dilutant, concentrate, dried product, or purified product. The composition for skin anti-aging is a cosmetic composition or food composition. The cosmetic composition also contains carrier and adjuvant such as antioxidant, stabilizing agent, solubilizing agent, vitamin, pigment, and perfume. The food composition contains citric acid, liquid fructose, sugar, glucose, acetic acid, and fruit juice.
Disclosed is a container system for peritoneal dialysis (PD) solutions, comprising: a first compartment containing a first PD osmotic agent, a second compartment containing a second PD buffer agent, wherein the first and second compartments are coupled, any of directly or indirectly, to support fluid transfer between the respective compartments, a first seal that prevents fluid transfer between the first compartment and the second compartment, and a second seal that prevents fluid transfer between one of the first and second compartments and an outlet fluid pathway of the container system, the container system configured to inhibit fluid transfer to the outlet fluid pathway prior to mixing of at least a portion of the first PD agent and the second PD agent. Also disclosed is a method of dispensing a peritoneal dialysis solution from a peritoneal dialysis (PD) container system, comprising the steps of: A. breaking a first seal in a PD container system of the type comprising i. a first compartment containing a first PD agent, ii. a second compartment containing a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, iii. a first seal preventing fluid transfer between the first compartment and the second compartment, iv. a second seal preventing fluid transfer between the second compartment and an outlet fluid pathway of the container, and v. a protective member adapted to inhibit breaking of the second seal prior to breaking of the first seal, B. sliding the protective member from a first position to a second position, and C. breaking of the second seal, when the protective member is in the second position, to allow fluid to exit the container system via an outlet. (61) Addition to 556770
Ischemic stroke is a leading cause of disability and death worldwide. Antiplatelet treatment is one of treatment strategies in secondary stroke prevention for patients with non-cardioemoblism etiology. However, a concerning issue is that wide interindividual variability in P2Y12 antagonist, especially clopidogrel. The rate on-treatment high platelet reactivity (HPR) can be as high as in one-third of patients with standard dose of clopidogrel( i.e. 75mg), and HPR has been noted in those who received other P2Y12 antagonists, such as ticagrelor and prasugrel. In the present study, we aimed to investigate the safety and potential therapeutic effect of individualized treatment of antiplatelet in secondary prevention in a cohort of patients with non-cardioembolic ischemic strokes.
Temsirolimus injection was evaluated in a dose escalation phase 1 study in 110 patients with normal or varying degrees of hepatic impairment as defined by AST and bilirubin levels and patients with liver transplant (Table 3). Patients with moderate and severe hepatic impairment had increased rates of adverse reactions and deaths, including deaths due to progressive disease, during the study (Table 3). 

Temsirolimus injection is contraindicated in patients with bilirubin >1.5×ULN [see Contraindications (4), and Warnings and Precautions (5.2)]. Use caution when treating patients with mild hepatic impairment. If Temsirolimus injection must be given in patients with mild hepatic impairment (bilirubin >1-1.5×ULN or AST >ULN but bilirubin ≤ULN), reduce the dose of Temsirolimus injection to 15 mg/week [see Dosage and Administration (2.4)]. Because there is a need for dosage adjustment based upon hepatic function, assessment of AST and bilirubin levels is recommended before initiation of Temsirolimus injection and periodically thereafter.
PURPOSE:To provide the new compound useful as an anti-inflammatory, analgesic and antipyrectic agent and having high safety. CONSTITUTION:Diellagic lactone of the formula. The compound is obtained by extracting dry Granati pericarpium with a solvent such as methanol at 15-50 deg.C, concentrating the extract solution, distributing the concentrated extract with a hydrophobic solvent (e.g. n-butanol) and subsequently recrystallization- purifying the separated compound. The compound of the formula as an active ingredient is prepared into an oral or parenteral shape in an amount of 0.1-500mg, preferably 1-50mg, per dose. The compound of the formula is administered at a dose of 1-500mg, preferably 2-100mg, per day for an adult. The diellagic lactone of the formula is the dimer of ellagic acid and has a hepatopaphy-inhibiting action.
Neuroinflammation is a hallmark of Alzheimer's disease (AD) and both positive and negative associations of individual inflammation-related markers with brain structure and cognitive function have been described. We aimed to identify inflammatory signatures of CSF immune-related markers that relate to changes of brain structure and cognition across the clinical spectrum ranging from normal aging to AD. A panel of 16 inflammatory markers, Aβ42/40 and p-tau181 were measured in CSF at baseline in the DZNE DELCODE cohort (n = 295); a longitudinal observational study focusing on at-risk stages of AD. Volumetric maps of gray and white matter (GM/WM; n = 261) and white matter hyperintensities (WMHs, n = 249) were derived from baseline MRIs. Cognitive decline (n = 204) and the rate of change in GM volume was measured in subjects with at least 3 visits (n = 175). A principal component analysis on the CSF markers revealed four inflammatory components (PCs). Of these, the first component PC1 (highly loading on sTyro3, sAXL, sTREM2, YKL-40, and C1q) was associated with older age and higher p-tau levels, but with less pathological Aβ when controlling for p-tau. PC2 (highly loading on CRP, IL-18, complement factor F/H and C4) was related to male gender, higher body mass index and greater vascular risk. PC1 levels, adjusted for AD markers, were related to higher GM and WM volumes, less WMHs, better baseline memory, and to slower atrophy rates in AD-related areas and less cognitive decline. In contrast, PC2 related to less GM and WM volumes and worse memory at baseline. Similar inflammatory signatures and associations were identified in the independent F.ACE cohort. Our data suggest that there are beneficial and detrimental signatures of inflammatory CSF biomarkers. While higher levels of TAM receptors (sTyro/sAXL) or sTREM2 might reflect a protective glia response to degeneration related to phagocytic clearance, other markers might rather reflect proinflammatory states that have detrimental impact on brain integrity.
The purpose of this study is to investigate the effect of montelukast on lipopolysaccharide (LPS)-induced pancreatitis. Adult male Wistar rats were divided into 5 groups: normal control, control montelukast, LPS group, and two LPS + montelukast-treated groups. Acute pancreatitis (AP) was induced by a single dose of LPS (6 mg/kg, i.p.), while montelukast was given in two different doses (10 and 20 mg/kg/day) for 3 consecutive days prior to the injection of LPS. AP was demonstrated by significant increases in serum levels of lactate dehydrogenase (LDH) and pancreatic enzymes lipase and amylase. Proinflammatory response activation was evident by elevated serum levels of nitric oxide (NO) and increased pancreatic concentrations of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1β), and intercellular adhesion molecule-1 (ICAM-1). The activity of myeloperoxidase (MPO), a neutrophil infiltration marker, has also been increased. Oxidative stress was confirmed by significant increases in the concentrations of lipid peroxides measured as thiobarbituric acid reactive substances (TBARS) and decreases in the concentrations of reduced glutathione (GSH) in the pancreatic tissues of animals treated with LPS. Histological examination confirmed the biochemical alterations. Montelukast treatment reversed all these biochemical indices and histopathological changes that LPS induced. Montelukast reduced the increase in serum levels of lipase, amylase, LDH, total nitrite/nitrate, TNF-α, IL-1β, and ICAM-1. MPO activities and TBARS concentrations were also suppressed while GSH content was increased in pancreatic tissues. These results show that montelukast may be a beneficial pharmacological agent in protection against LPS-induced oxidative pancreatic injury by inhibiting neutrophil infiltration, counteracting oxidative stress, and suppressing inflammatory mediators.
OBJECTIVE: To investigate the expression of programmed death ligand-1 (PD-L1) in circulating exosomes, and to define the role of exosomal PD-L1 in promoting immune escape mechanism during chronic hepatitis B infection (CHB) and related liver diseases.
METHODS: The levels of PD-L1 expressed in exosomes were detected by ELISA. CD8+T cells were sorted and cytotoxicity test was assessed by flow cytometry. PD-L1 protein expression in hepatocellular carcinoma (HCC) and normal adjacent tissues were detected by immunohistochemistry.
RESULTS: Circulating exosomal PD-L1 levels were significantly higher in patients with CHB and HCC than in healthy controls (F =7.46, P=0.001). Levels of CD107a on CD8+T cells in patients with CHB receiving PD-L1 blocking antibody were significantly lower than in patients receiving isotype blocking antibody (t = 4.96, P < 0.01). Levels of TNF-α in cell culture supernatants of the PD-L1 blocking antibody group were significantly higher than in the isotype blocking antibody group (t =5.92, P < 0.01). Compared with patients receiving isotype blocking antibody, levels of CD107a on CD8+T cells significantly increased in patients with HCC receiving anti-PD-L1 antibody (t = 3.51, P<0.05). Compared with adjacent tissues, the levels of PD-L1 protein expression in HCC tissues were slightly higher; however, no significant difference between the two groups was observed.
CONCLUSIONS: PD-L1 blockade in exosomes might promote the cytotoxic function of CD8+T cells and inhibit immune evasion during progression of HCC. Blocking PD-L1 in exosomes reduced the cytotoxic function of CD8+T cells in patients with CHB while enhancing the production of proinflammatory cytokines.