anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A combination immunostimulant for increasing the body's own immune defence mechanism consists of a combination of extracts of Eleutherococcus sertiocus, spleen and thymus as the active ingredients of Dr Weger's natural immunostimulant, the individual components only causing a significant measurable increase in the immune defence mechanism when used together. An immunostimulant for prophylactic use consists of an alcoholic extract of Eleutherococcus sertioccus dissolved in blackcurrant juice in ratio 1:4. This prod. can be used as an immunostimulant for prophylaxis of healthy people and as a natural prod. to provide trace elements and vitamin C. USE/ADVANTAGE - The combination prepn. provides bodies weakened by AIDS, cancer, leukaemia etc. with the necessary building blocks, such as glycopeptides required for immune defence. The combination increases the T-cells after damage by HIV, increases the body's own interferons and immunoglobulins, increases the overall feeling of bodily health, increases body weight which has been reduced by AIDS and causes considerably recovery or even healing of opportunistic diseases resulting from immune deficiency. The spleen and thymus extracts enable Eleutherococcus to develop its adaptogenous effect, i.e. in the direction of normalisation. The combination is synergistic. The mixt. of Eleutherococcus and blackcurrent juice helps the body's own defence system to recognise and kill potential cancer cells, thus inhibiting the occurrence of canc na
Bilingual schools have more hours and high levels of academic demands. Aims: To compare the degree of dental wear and frequency of severe wear facets between children from public rural schools (RG) and children from private bilingual schools in Buenos Aires City (PG). To compare the presence of facets to parents' reports on bruxism and their opinion on the importance to health of bruxism and snoring. Materials and Method: The sample (n=90) consisted of 5- and 10-year-old children. Their parents/guardians were asked to complete a structured questionnaire on bruxism and snoring. Children's degrees of dental wear on primary incisors, canines and molars were identified and recorded. The data were analyzed statistically. Results: The relative risk of wear between PG and RG was 1.82. Bruxism and snoring were reported by 22.9% of the parents/guardians of 5-year-olds and 8.8% of the parents/guardians of 10-year-olds. In 10-year-olds, significant differences were found between RG and PG for canine wear degree 3 (p=0.01). Conclusions: Children from highly demanding schools presented more dental wear. Higher frequency of severe dental wear was observed in primary canines and molars late in the tooth replacement period regardless of whether sleep bruxism was reported. Parents/guardians from different social conditions considered that bruxism and snoring are important to health to similar degrees.
The increase in the number and proportion of the elderly population poses various challenges, especially in the health sector. The elderly tend to be more vulnerable to health problems, such as malnutrition and frailty. Data on the prevalence of malnutrition and frailty in the elderly can be used as a basis for taking preventive and treatment measures for both conditions. This study aims to determine the prevalence of malnutrition and frailty in the elderly in the Bandung City community.

Descriptive research with a cross-sectional approach was conducted on 71 elderly participants in the Bandung City community. The sampling method used was consecutive sampling. The study used the Mini Nutritional Assessment-Short Form (MNA-SF) questionnaire to assess malnutrition and the Kihon Checklist (KCL) to assess frailty.
PURPOSE: Composite particles are provided to reduce the coherence of particles through electrospray drying, to ensure small and constant shaped particle size and effective sustained release. CONSTITUTION: Composite particles comprise a cationic polymer and an anionic polymer. The polymer has a core-shell structure which is not cross-linked by electrospray drying. The polymers are cross-linked with water. The cationic polymer comprises a compound with an amine group. A method for preparing the composite particles comprises: preparing a crosslinkable cationic polymer, or an anionic polymer solution; and electrospray drying the polymer solution through two co-axial nozzles.
A multi-functional, computer-aided gastroscopy system optimized with integrated AI solutions is disclosed. The system makes use of multiple deep-learning neural models to achieve low latency and high-performance requirements for multiple tasks. The optimization is made at three levels: architectural, modular and functional level. At architectural level, the models are designed in such a way that it is able to accomplish HP infection classification and detection of some lesions for one inference in order to reduce computation costs. At modular level, as a sub-model of HP infection classification, the site recognition model is optimized with temporal information. It not only improves the performance of HP infection classification, but also plays important roles for lesion detection and procedure status determination. At functional level, the inference latency is minimized by configuration and resource aware optimization. Also at functional level, the preprocessing is speeded up by image resizing parallelization and unified preprocessing.
FIELD: medicine.SUBSTANCE: present invention relates to medicine, namely to proctology, and relates to the treatment of chronic hemorrhoids in elderly and senile patients. For this, sclerotherapy is carried out by introducing a solution of Ethoxysclerol into the internal hemorrhoids. The drug is injected simultaneously into no more than two hemorrhoids. The procedure is performed in three steps with an interval of 10 days. Injections into different hemorrhoids are performed alternately, at the rate of two injections of 1% Ethoxysclerol solution in each node during the course of treatment. From the first day of sclerotherapy, Detralex 500 mg is prescribed 2 times a day after meals, for a course of 30 days and the introduction of Nigepan rectal suppositories into the intestine, one suppository for 5 days after each sclerotherapy procedure. Additionally, if a patient has a level of 31 points or more on the Spielberg scale, Valerian extract is prescribed, 2 tablets 3 times a day, or Afobazol, a tablet 3 times a day, the course of treatment is 30 days.EFFECT: method provides effective treatment in the absence of complications and relapses within 6 months after the end of the course.1 cl, 1 ex, 4 tbl
Patients in the Compression group would be subject to application of standardized lower extremity, thigh-high, elastic compression stockings within 24 hours of admission. Appropriate size of the stockings would be based on calf circumference, thigh circumference and leg length. The compression would be applied throughout the entire duration of hospitalization, provided the patient is able to tolerate it. Daily thorough skin checks for any cutaneous defects or lesions will be performed, and mobilization encouraged.
N Safety and effectiveness of Glipizide and Metformin HCl Tablets in pediatric patients have not been established.

Geriatric Use

Of the 345 patients who received Glipizide and Metformin HCl Tablets 2.5 mg/250 mg and 2.5 mg/500 mg in the initial therapy trial, 67 (19.4%) were aged 65 and older while 5 (1.4%) were aged 75 and older. Of the 87 patients who received Glipizide and Metformin HCl Tablets in the second-line therapy trial, 17 (19.5%) were aged 65 and older while 1 (1.1%) was at least aged 75. No overall differences in effectiveness or safety were observed between these patients and younger patients in either the initial therapy trial or the second-line therapy trial, and other reported clinical experience has not identified differences in response between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy and the higher risk of lactic acidosis. Assess renal function more frequently in elderly patients (see also WARNINGS, PRECAUTIONSand DOSAGE AND ADMINISTRATION).
No vaccines and few chemoprophylaxis options exist for the prevention of bacterial sexually transmitted infections (STIs) (specifically syphilis, chlamydia, and gonorrhea). These infections have increased in the United States and disproportionately affect gay, bisexual, and other men who have sex with men (MSM) and transgender women (TGW). In three large randomized controlled trials, 200 mg of doxycycline taken within 72 hours after sex has been shown to reduce syphilis and chlamydia infections by >70% and gonococcal infections by approximately 50%. This report outlines CDC's recommendation for the use of doxycycline postexposure prophylaxis (doxy PEP), a novel, ongoing, patient-managed biomedical STI prevention strategy for a selected population. CDC recommends that MSM and TGW who have had a bacterial STI (specifically syphilis, chlamydia, or gonorrhea) diagnosed in the past 12 months should receive counseling that doxy PEP can be used as postexposure prophylaxis to prevent these infections. Following shared decision-making with their provider, CDC recommends that providers offer persons in this group a prescription for doxy PEP to be self-administered within 72 hours after having oral, vaginal, or anal sex. The recommended dose of doxy PEP is 200 mg and should not exceed a maximum dose of 200 mg every 24 hours.Doxy PEP, when offered, should be implemented in the context of a comprehensive sexual health approach, including risk reduction counseling, STI screening and treatment, recommended vaccination and linkage to HIV PrEP, HIV care, or other services as appropriate. Persons who are prescribed doxy PEP should undergo bacterial STI testing at anatomic sites of exposure at baseline and every 3-6 months thereafter. Ongoing need for doxy PEP should be assessed every 3-6 months as well. HIV screening should be performed for HIV-negative MSM and TGW according to current recommendations.
Macrophage is the main effector cell during atherosclerosis. We applied single-cell RNA sequencing (scRNA) data to investigate the role of macrophage subsets in atherosclerosis. Monocyte and macrophage clusters were divided into 6 subclusters. Each subcluster's markers were calculated and validated by immunofluorescence. Elevated macrophage subclusters in the WD group were subject to enrichment pathway analysis and exhibited different phenotypes. Pseudotime analysis shows the subclusters originate from monocytes. We cultured bone marrow-derived macrophages with CSF-1 and ox-LDL to simulate an atherosclerotic-like environment and detected the transformation of subclusters. Macrophage-Vegfa and Macrophage-C1qb increased in the WD group. Macrophage-Vegfa acquires the characteristics of phagocytosis and immune response, while Macrophage-C1qb is not involved in lipid metabolism. The two subclusters are both enriched in cell movement and migration pathways. Experimental verification proved Monocyte-Ly6C evolved into Macrophage-Vegfa and Macrophage-C1qb during atherosclerosis progression.
FABIOR Foam is for topical use only. FABIOR Foam is not for oral, ophthalmic, or intravaginal use.

FABIOR Foam should be applied once daily in the evening after washing with a mild cleanser and fully drying the affected area. Dispense a small amount of foam into the palm of the hand. Using fingertips, apply only enough foam to lightly cover the entire affected areas of the face and/or upper trunk with a thin layer; gently massage the foam into the skin until the foam disappears. Avoid the eyes, lips, and mucous membranes. Wash hands after application.

Patients may use moisturizer as needed.

If undue irritation (redness, peeling, or discomfort) occurs, patients should reduce frequency of application or temporarily interrupt treatment. Treatment may be resumed once irritation subsides. Treatment should be discontinued if irritation persists.
A method of making gel particles of uniform size and morphology is described herein. By the agglomeration method, a large amount of gel microparticle slurry can be produced by increasing the reactor size. The particles may be repeatedly dehydrated and rehydrated depending on their environment, allowing the particles to be stored in a non-solvent such as ethanol. The gel paste exhibits bingham plastic behavior, wherein the paste behaves as a solid at shear stresses below a critical value. Upon reaching a critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behaviour of these slurries can be tuned by varying the compaction process such as centrifugal force to alter the yield stress. The narrower distribution and reduced size of these particles allows for an increase in the fidelity of FRESH printing.
Dysphagia is a frequent and potentially serious complication of stroke. However, there is no effective measure for the treatment of pharyngeal dysphagia in stroke patients. This study aims to explore the efficacy of stellate ganglion block in post-stroke pharyngeal dysphagic patients who received comprehensive rehabilitation. This was a multicenter randomized controlled study. 66 post-stroke patients with pharyngeal dysphagia were randomly allocated to the observation group (n=33) or the control group (n=33). Both groups were provided with comprehensive rehabilitation including routine rehabilitation and swallowing function training. Besides, the observation group additionally underwent the stellate ganglion block (SGB). At admission and after 20-day treatment, Kubota water swallowing test, video fluoroscopic swallowing study (VFSS), and Rosenbek penetration-aspiration scale (PAS) were used to assess swallowing function.
Objective: To determine patients' perspectives on home monitoring at emergency department (ED) presentation and shortly after admission and compare these with their physicians' perspectives. Methods: Forty Dutch hospitals participated in this prospective flash mob study. Adult patients with acute medical conditions, treated by internal medicine specialties, presenting at the ED or admitted at the admission ward within the previous 24 h were included. The primary outcome was the proportion of patients who were able and willing to undergo home monitoring. Secondary outcomes included identifying barriers to home monitoring, patient's prerequisites, and assessing the agreement between the perspectives of patients and treating physicians. Results: On February 2, 2023, in total 665 patients [median age 69 (interquartile range: 55-78) years; 95.5% community dwelling; 29.3% Modified Early Warning Score ≥3; 29.5% clinical frailty score ≥5] were included. In total, 19.6% of ED patients were admitted and 26% of ward patients preferred home monitoring as continuation of care. Guaranteed readmission (87.8%), ability to contact the hospital 24/7 (77.3%), and a family caregiver at home (55.7%) were the most often reported prerequisites. Barriers for home monitoring were feeling too severely ill (78.8%) and inability to receive the required treatment at home (64.4%). The agreement between patients and physicians was fair (Cohens kappa coefficient 0.26). Conclusions: A substantial proportion of acutely ill patients stated that they were willing and able to be monitored at home. Guaranteed readmission, availability of a treatment team (24/7), and a home support system are needed for successful implementation of home monitoring in acute care.
The use of TOSYMRA is contraindicated in patients with ischemic or vasospastic CAD. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of sumatriptan. Some of these reactions occurred in patients without known CAD. 5-HT1 agonists, including TOSYMRA, may cause coronary artery vasospasm (Prinzmetal’s angina), even in patients without a history of CAD.

Perform a cardiovascular evaluation in triptan-naive patients who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) prior to receiving TOSYMRA. If there is evidence of CAD or coronary artery vasospasm, TOSYMRA is contraindicated. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of TOSYMRA in a medically supervised setting and performing an electrocardiogram (ECG) immediately following administration of TOSYMRA. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of TOSYMRA.
Methods for preferentially delivering an active agent intracellularly to a reservoir cell that is infected with or susceptible to infection with an infectious agent, such as HIV. The active agent is part of a lipid-active agent complex that has a targeting ligand, such as a CTL/CTLD receptor-specific anchor, on its outer surface. Targeting systems are also disclosed.  Such targeting systems are comprised of lipid-active agent complexes that contain targeting ligands, such as fucose and polyfucose derivatives, on their outer surfaces. The active agents include plant lectins, such as Con-A and MHL, and other drugs. Such methods and targeting systems may be used in the treatment of HIV and other infectious and non-infectious diseases.
Patients wear an activity monitor (Fitbit) for 90 days. Patients also undergo collection of blood samples and complete questionnaires twice weekly for up to 90 days.
Immediate use of esTOCma mobile app. Participants will use the mobile application immediately after the baseline assessment (T0) during approximately 10 days or until app completion.
ABSTRACT OF THE DISCLOSURE           This invention discloses a new and commercially useful process for the preparation of phenoxypropylamine derivatives of the general formula (I):            (I)   and the acid addition salts thereof wherein, R is a hydrogen or an alkyl group, R1 is a hydrogen atom, an alkyl, cycloalkyl, aralkyl or aryl group or R and R1 together represent a divalent, optionally branched hydrocarbon, optionally substituted, R2 is a hydrogen atom or an alkyl, aralkyl or aryl group, R3 is an alkyl, hydroxyalkyl, cycloalkyl or cyanoalkyl group and R4 is a hydrogen atom, a lower alkyl group or an aralkyl group.  This process comprises reacting a p-aminophenol derivative or mixture of derivatives of the general formula (II)                      (II) wherein R5 is a hydrogen atom or the group   and X is       or      ,   with  an amine of general ABSTRACT OF THE DISCLOSURE cont.:   formula (III)          (III) and when R5 is the group      the product of the formula I is isolated as the free base or acid addition salt thereof. When R5 is hydrogen, it is converted to the group        by addition of a carbamic acid halide of general formula IV                      (IV) and then the product of general formula I is isolated as the free base or acid addition salt.  When R5 is hydrogen, in order to obtain compounds of formula I in which R is hydrogen an iso-cyanate of the general formula (V) O = C = N - R1            (V) is added and then the product of formula (I) is  isolated as the free base or acid addition salt thereof.  Such compounds are useful in the therapeutic treatment of various cardiac illnesses whose actiologg or symptoms may be explained by an undesirably high content of endogenous catecholamines in the circulation.
Participants receive an active essential oil blend to inhale for 15 minutes. The blend contains plant based oils sourced from flowers and citrus plants.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no ideal drugs. Our previous research demonstrated that phosphodiesterase 1 (PDE1) could be a promising target for the treatment of IPF. However, only a few selective PDE1 inhibitors are available, and the mechanism of recognition between inhibitors and the PDE1 protein is not fully understood. This study carried out a step-by-step optimization of a dihydropyrimidine hit Z94555858. By targeting the metal pocket of PDE1, a lead compound 3f was obtained, exhibiting an IC50 value of 11 nM against PDE1, moderate selectivity over other PDEs, and significant anti-fibrotic effects in bleomycin-induced pulmonary fibrosis rats. The structure-activity relationship study aided by molecular docking revealed that forming halogen bonds with water in the metal pocket greatly enhanced the PDE1 inhibition, providing a novel strategy for further rational design of PDE1 inhibitors.
BACKGROUND & AIMS: The association between trunk muscle mass or trunk function or trunk muscle strength and activities of daily living (ADLs) has been reported, but no studies have examined the impact of increased trunk muscle mass on trunk function or ADL. This study aimed to determine whether increased trunk muscle mass is associated with trunk function and ADL in older individuals with cerebral infarction during rehabilitation.
METHODS: This retrospective observational study enrolled 158 patients with cerebral infarction aged ≥65 years who were admitted for post-stroke rehabilitation. The trunk muscle mass index (TMI) was calculated at admission and discharge using bioelectrical impedance analysis. Patients were divided into two groups: one with increased TMI (64 participants; 41 %) and the other without TMI increase (94 participants; 59 %). Multiple linear regression analysis was performed with functional assessment for control of trunk (FACT) or functional independence measure (FIM)-motor gain as the objective variable and increased TMI group as the explanatory variable.
RESULTS: We analyzed a total of 158 patients (79.5 ± 7.8 years of age, 51.9 % men). TMI increase was independently associated with FACT gain (coefficient = 1.413, 95 % confidence interval = 0.34-2.49, P = 0.010), but not with FIM-motor gain.
CONCLUSIONS: The results suggest that increased TMI is independently associated with recovery of trunk function. Further prospective studies are needed to elucidate the relationship between increased TMI and ADL.
PROBLEM TO BE SOLVED: To provide receptors which are easy to produce and can advantageously be used for medical or diagnostic applications.SOLUTION: The recombinant soluble Fc receptors of the invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. This type of Fc receptor can be easily obtained by expressing respective nucleic acids in prokaryotic host cells and renaturing the obtained inclusion bodies. By this method, very homogenous and pure products can be obtained. Such products can be used for diagnostic and pharmaceutical applications, further for generating crystal structure data. Such crystal structure data can be used for modeling of artificial molecules. A further embodiment comprises coupling the Fc receptor of the invention to a solid material such as chromatography materials for isolation and/or concentration of antibodies.
The invention discloses a preparation method and application of a mixed CART cell. Specifically, the CART cells prepared by the invention are equal amounts of mixed CD19-CD28 CART cells and CD19-41BB CART cells. The mixed CART cell prepared by the invention has strong killing function on specific tumor cells. The mixed CART cell prepared by the invention has the characteristics of long survival period besides the strong killing function on tumor cells. The mixed CART cells prepared by the invention can be used for immunotherapy of malignant tumors mediated by CD19, including leukemia and lymphoma. The mixed CART cells prepared by the invention lay a solid foundation for basic research and clinical experiments.