anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To solve a problem such that a good textural quality can not be obtained by the hair dyeing with henna.  <P>SOLUTION: This hair dyestuff is obtained by mixing alkali ion water with the henna. Therefore, it is possible to swell/soften the hair by the alkali ion water for improving the penetrating property of a Lawson 23 which is a pigment contained in the henna, to the inside of the hair 21. Thus, the Lawson 23 becomes easily entering into the hair and it is possible to markedly improve its penetrating property, etc. As a result, it is possible to perform the hair dyeing surely and also improve the fixing property of a color, while markedly shortening the time for standing still by the improvement of the penetrating property, etc., caused by the alkali ion water.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The present disclosure provides a thiooligonucleotide injection and a preparation method thereof. The formulation comprises an aqueous solution of a thio antisense oligonucleotide targeting the IGF1R gene. The preparation method of such formulations comprises formulating an aqueous solution comprising a thio antisense oligonucleotide targeting the IGF1R gene and optionally adding an injectable pharmaceutically acceptable carrier. The disclosure also provides a lyophilized formulation comprising an aqueous solution of a thio-antisense oligonucleotide targeting the IGF1R gene, and a method of preparing the lyophilized formulation. Further, the present disclosure also provides uses of the above injection formulation and lyophilized formulation in treating cancers associated with IGF1R gene. By using the method disclosed by the invention, the stability of the oligonucleotide is increased, the expression of the targeted gene can be effectively inhibited, and the growth of tumors is inhibited.
A pilot, non-randomized, open-label study of two intervention arms and controlled with the standard treatment in which 60 patients affected with acute hemorrhage due to severe trauma will enter the study with the main objective of evaluating the feasibility and the efficacy of early treatment during the pre-hospital care phase with packed red blood cells, fibrinogen concentrate and tranexamic acid (experimental arm) compared to the standard treatment based on crystalloids administration and tranexamic acid (control arm). The secondary objectives are to evaluate the safety and clinical evolution of the patients. Prior to the administration of the treatment, 2 blood samples will be extracted in both groups in order to compare the coagulation status and to be able to perform the pre-transfusion tests. On arrival at the hospital, another sample will be taken to compare changes in coagulation after the administration of the experimental or standard treatment and also between both groups. The assessment of the coagulation status will be made using the values provided by the viscoelastic test (TEG6s). The experimental and standard treatment will be administered endovenously. After treatment, patients will be evaluated up to 30 days.
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel omega-hydrofluoroalkyl esters that are in liquid state under normal conditions and show properties of surface-active substances and can be used for water displacement from surfaces, in compositions used for removal of pollutant from article, in composition used in fire extinguishing, for foam plastic making, in soldering in vapor phase. Esters correspond to the formula (I):   where H is hydrogen atom in terminal group CF 3 ; R f , R f′  and R f″  are taken independently from the group consisting of linear unsubstituted perfluoroalkylene groups or perfluoroalkylene groups substituted with perfluoroalkyl being Rf has 4-9 carbon atoms in chain; Rf′ has 1-6 carbon atoms in chain; Rf″ has 2-6 carbon atoms in chain; n = 0-7 but at n = 0 Rf has perfluorocycloalkyl-substituted perfluoroalkylene group with 6-10 carbon atoms where one or more carbon atoms in Rf can be substituted with oxygen atoms; Rf′ Rf″ are taken independently among the group of linear unsubstituted perfluoroalkylene groups having 1- 4 carbon atoms in chain. Method of synthesis of esters involves decarboxylation of the corresponding perfluorocarboxylic acid or its ester by mixing with inorganic base solution in protonic solvent followed by heating. Invention involves also novel perfluorocarboxylic acids or their esters as the parent compounds used for synthesis of esters of the formula (I). New esters ensure to replace substances that destroy the earth ozone layer. EFFECT: new compounds indicated above, improved method of synthesis, valuable properties. 10 cl, 5 tbl, 45 ex
In the United States (US), parents' decision to delay or refuse vaccines for their children has resulted in pockets of under-vaccination as well as recurring outbreaks of vaccine-preventable diseases. To increase childhood vaccinations and stem recurring outbreaks, there is a need for effective interventions that build parents' confidence in vaccines and reduce their vaccine hesitancy. The first recommended routine vaccination for children is due at birth. Yet, many parents lack timely or evidence-based information on childhood vaccinations prior to their child's birth. Hence, the researchers of this study propose to evaluate ADEPT - an adaptive intervention that is implemented in prenatal care settings to proactively connect expectant parents with evidence-based information on vaccines recommended during pregnancy and for children after birth. The core component of ADEPT includes prenatal provider trainings and a recommendation to pregnant individuals encouraging vaccinations during pregnancy and for children after birth. Those pregnant individuals who remain vaccine-hesitant despite the provider recommendation will receive adaptive intervention components, which include evidence-based educational materials on vaccinations and phone consultations with a vaccine navigator to discuss any residual concerns.

In the proposed study, ADEPT will be implemented and evaluated in diverse prenatal care practices in North Carolina. Study prenatal care practices will be randomized to the ADEPT intervention or standard of care to pregnant individuals. Individuals receiving prenatal care at a clinic implementing ADEPT will be screened for vaccination intention following the provider recommendation. Vaccine-hesitant pregnant individuals will be offered enrollment into a nested sub-study designed to assess the implementation of the ADEPT intervention. After the pregnant individuals in the intervention and control arms give birth, the researchers will assess their children's vaccination outcomes at birth, 2, 4, 6, and 12 months using data from the North Carolina Immunization Registry (NCIR). The primary study outcome is the difference in timely childhood vaccination at 2 months between the intervention and control arms. In addition, maternal vaccination data will be collected from NCIR for vaccines during pregnancy.
Group treated with the Twicare® appliance. This appliance is a removable mandibular propulsive adjustable preformed medical device. It is made out of soft and stiff thermoplastics. Its two gutters are linked to each other according to different antero-posterior positions. It is EC marked since 2011.
BACKGROUND: Hazardous drinking has been associated with chronic pain in community and medical samples. The purpose of this study was to develop a novel, integrated mobile health intervention that improves pain management and reduces hazardous drinking that may be implemented in primary care settings.
METHODS: Forty-eight participants with moderate or greater chronic pain and hazardous drinking were recruited from primary care clinics and through social media sites. Following baseline assessment, participants were randomized to a counselor-supported smartphone app intervention (INTV) or a counselor delivered treatment-as-usual control condition (CTL).
RESULTS: Results supported the feasibility and acceptability of the smartphone app intervention. Participants found it easy to use, reported high levels of satisfaction, and showed high levels of engagement with the app. Between-group effect size estimates at follow-up showed small effects for the intervention on pain ratings. However, using clinically meaningful change thresholds of 30% and 50% improvement in pain scores, 38% and 25% respectively of those in the INTV condition showed reductions compared to 20% and 12.5% respectively in the CTL condition. Effect size estimates did not indicate intervention superiority on alcohol outcomes as participants in both conditions showed considerable reductions in drinking over the course of the study.
CONCLUSIONS: Results supported the view that a mobile health intervention delivered via smartphone with electronic coaching is a feasible and acceptable method of addressing chronic pain among those who engage in hazardous drinking. Future work should test the efficacy of this approach in a fully powered trial.
Obesity and fatty liver diseases-metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)-affect over one-third of the global population and are exacerbated in individuals with reduced functional aldehyde dehydrogenase 2 (ALDH2), observed in approximately 560 million people. Current treatment to prevent disease progression to cancer remains inadequate, requiring innovative approaches. We observe that Aldh2-/- and Aldh2-/-Sptbn1+/- mice develop phenotypes of human metabolic syndrome (MetS) and MASH with accumulation of endogenous aldehydes such as 4-hydroxynonenal (4-HNE). Mechanistic studies demonstrate aberrant transforming growth factor β (TGF-β) signaling through 4-HNE modification of the SMAD3 adaptor SPTBN1 (β2-spectrin) to pro-fibrotic and pro-oncogenic phenotypes, which is restored to normal SMAD3 signaling by targeting SPTBN1 with small interfering RNA (siRNA). Significantly, therapeutic inhibition of SPTBN1 blocks MASH and fibrosis in a human model and, additionally, improves glucose handling in Aldh2-/- and Aldh2-/-Sptbn1+/- mice. This study identifies SPTBN1 as a critical regulator of the functional phenotype of toxic aldehyde-induced MASH and a potential therapeutic target.
Participants diagnosed with hypoxia negative human papilloma virus (HPV) associated oropharyngeal carcinoma (OPC). Cohort D will just have T1- T2N0 participants. Paclitaxel can be substituted with Abraxane (Albumin-bound Paclitaxel). Will follow the guidelines for Cohort A and Cohort B for chemotherapy options.
Participants wait one year before receiving the intervention. Three assessments are taken over this period: Month 3, Month 9, and Month 12.
OBJECTIVES: Central retinal artery occlusion (CRAO) is a stroke of the retina potentially amenable to intravenous thrombolysis (IVT). We aimed to determine feasibility of an emergency treatment protocol and risk profile of IVT for CRAO in a comprehensive stroke center (CSC).
METHODS: We performed a retrospective, observational cohort study including patients with acute CRAO admitted to a CSC over 4 years. Patients are offered IVT if they present with acute vision loss of ≤ 20/200 in the affected eye, have no other cause of vision loss (incorporating a dilated ophthalmologic exam), and meet criteria akin to acute ischemic stroke. We collected socio-demographic data, triage data, time from onset to presentation, IVT candidacy, and rates of symptomatic intracranial hemorrhage (sICH)- or extracranial hemorrhage.
RESULTS: 36 patients presented within the study period, mean (standard deviation (SD)) age of 70.7 (10), 52 % female, and median time (Q1, Q3) to ED presentation of 13.5 (4.3, 18.8) h. Patients within 4.5 h from onset presented more commonly directly to our ED (66.6 % vs 37.1 %, p = 0.1). Nine patients (25 %) presented within the 4.5 h window. Of those eligible, 7 (77 %) received IVT. There were no events of intracranial or extracranial hemorrhage.
CONCLUSIONS: Our study confirmed that IVT for acute CRAO is feasible. We found a high rate of treatment with IVT of those eligible. However, because 75 % of patients presented outside the treatment window, continued educational efforts are needed to improve rapid triage to emergency departments to facilitate evaluation for possible candidacy with IVT.
PURPOSE: One highlighted pathogenesis mechanism of diseases is the negative impact of pro-inflammatory diets (PD) on the gut microbiome. This systematic review aimed to study the link between dietary inflammatory index (DII), as an indicator of PD, and gut microbiome.
METHODS: A systematic search was done in PubMed and Scopus, adhering to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The assessment of the included studies' quality was performed using the critical appraisal checklist from the Joanna Briggs Institute.
RESULTS: Ten articles were included eight cross-sectional, one case-control, and, one cohort study. Seven and three included articles reported a weak and moderate relationship between gut microbiome and DII scores, respectively. DII scores were linked to variety in microbiome composition and diversity/richness. More importantly, anti-inflammatory diets as measured by lower DII scores were linked to a more desirable gut microbiome profile. Prevotella stercorea, Veillonella rogosae, Morganella morganii, Ruminococcus torques, Eubacterium nodatum, Alistipes intestine, Clostridium leptum, Morganellaceae family, Enterobacteriaceae family, and, Bacteroides thetaiotaomicron were related to higher DII scores. While, Butyrate-producing bacteria such as Ruminococcaceae and Lachnospiraceae families, Faecalibacterium prausnitzii, and Akkermansia muciniphila were related to lower DII scores.
CONCLUSION: An anti-inflammatory diet, as measured by a lower DII score, might be linked to variations in the composition and variety of the microbiome. Therefore, the DII score could be useful in microbiota research, however, this possibility needs to be investigated more precisely in future studies.
PURPOSE:To provide the titled composition having high chemical stability and bioavailability, by culturing a yeast in a sugar-containing nutrient medium containing an iron compound under anaerobic condition. CONSTITUTION:A yeast strain, preferably Saccharomyces cerevisiae, is cultured in a sugar-containing nutrient medium containing an iron compound (e.g. ferric chloride, ferric sulfate, etc.) under anaerobic condition to obtain the titled composition in high efficiency. The medium is preferably a synthetic or semisynthetic medium containing an organic acid salt (e.g. malic acid salt, citric acid salt, etc.) and calcium chloride. The proliferation of yeast can be improved remarkably, and a soluble organic ferric compound having high bioavailability can be produced in high concentration. The production yield is improved remarkably, and the production time is shortened.
<P>PROBLEM TO BE SOLVED: To provide a calcium phosphate composition with its hardening time within an appropriate range and with an excellent marginal sealing property, the hardening time being the time necessary for the composition to harden after a medical solution is applied to the composition to be used in clinical practice.  <P>SOLUTION: The calcium phosphate composition includes calcium phosphate particles (A) and layered silicate particles (E). The calcium phosphate composition is characterized by inclusion of 0.5-30 pts.wt. of the layered silicate particles (E) based on 100 pts.wt. of the calcium phosphate particles (A).  <P>COPYRIGHT: (C)2009,JPO&INPIT
Mammalian brains represent information using distributed population codes which provide a number of advantages from robustness to high representational capacity. However, for downstream readout neurons such codes pose formidable high-dimensional learning problems as a very large number of synaptic connections must be adjusted during learning in search of a suitable readout. Our recent theoretical work hypothesized that these high-dimensional learning problems can be simplified by inductive biases implemented through stimulus-independent noise correlations which express the degree to which a pair of neurons covary in their trial-to-trial fluctuations. While noise correlations have traditionally been viewed as providing constraints on representational capacity our recent work demonstrates that they simultaneously constrain readout learning. In some biologically relevant cases, they could theoretically speed learning by shaping the geometry of the underlying neural space to focus the gradient of learning onto task-relevant dimensions. However, this hypothesized role of noise correlations in shaping learning has not yet been empirically tested. Here the investigators elaborate an experimental framework to test the predicted role of noise correlations, as measured through covariation in fMRI multi-voxel BOLD activity patterns for a given stimulus, on learning in both familiar and novel contexts. In familiar contexts, useful noise correlations may be induced by top-down inputs from the prefrontal cortex that signal relevant task dimensions. Thus, the strength of noise correlations in task-relevant dimensions would predict faster learning about task-relevant features. On the other hand, in novel contexts when the relevant task dimensions are unknown, noise correlations may force gradients onto task-irrelevant dimensions and thus impair learning. Therefore, suppressing noise correlations, which might be achieved through neuromodulatory signaling, may speed learning by reducing bias early during learning or after a change in the task-relevant stimulus. Across our Aims, the investigators develop a plan to test the most basic predictions of our computational model using fMRI to characterize the geometry of noise correlations and pupillometry as a proxy for neuromodulatory signaling in human subjects. The planned research will provide the first empirical test of the role of noise correlations in learning.
The invention discloses a high-stereo and highly-enantioselective oxazolinedione compound, a preparation method and an application thereof. The structural formula of the compound is as shown in the specification, wherein Ar=Ph, m-ClPh, m-MePh and m-MeOPh. The high-stereo and highly-enantioselective oxazolinedione compound is synthesized by a new method. The high-stereo and highly-enantioselective oxazolinedione compound has different degrees of characteristics of inhibiting H22 hepatocarcinoma cell activity. At present, the method hasn't been reported. The new method has the following advantages: the method can be adopted universally; cost is low; reaction path is short; postprocessing is simple; and by highly efficient preparation of the compound, a highly diastereoselective compound with high optical purity is obtained.
BACKGROUND: African Americans have the highest prevalence of chronic Hepatitis C virus (HCV) infection. Racial disparities in outcome are observed after elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). This study sought to identify if disparities in treatments and outcomes exist between Black and White patients who have HCV prior to elective THA and TKA.
METHODS: Patient demographics, comorbidities, HCV characteristics, perioperative variables, in-hospital outcomes, and postoperative complications at 1-year follow-up were collected and compared between the 2 races. Patients who have preoperative positive viral load (PVL) and undetectable viral load were identified. Chi-square and Fisher's exact tests were used to compare categorical variables, while 2-tailed Student's Kruskal-Wallis t-tests were used for continuous variables. A P value of less than .05 was statistically significant.
RESULTS: The liver function parameters, including aspartate aminotransferase and model for end-stage liver disease scores, were all higher preoperatively in Black patients undergoing THA (P = .01; P < .001) and TKA (P = .03; P = .003), respectively. Black patients were more likely to undergo THA (65.8% versus 35.6%; P = .002) and TKA (72.1% versus 37.3%; 0.009) without receiving prior treatment for HCV. Consequently, Black patients had higher rates of preoperative PVL compared to White patients in both THA (66% versus 38%, P = .006) and TKA (72% versus 37%, P < .001) groups. Black patients had a longer length of stay for both THA (3.7 versus 3.3; P = .008) and TKA (4.1 versus 3.0; P = .02).
CONCLUSIONS: The HCV treatment prior to THA and TKA with undetectable viral load has been shown to be a key factor in mitigating postoperative complications, including joint infection. We noted that Black patients were more likely to undergo joint arthroplasty who did not receive treatment and with a PVL. While PVL rates decreased over time for both races, a significant gap persists for Black patients.
PROBLEM TO BE SOLVED: To obtain an odorless polyoxypropylene diglyceryl ether, emitting no malodor with time and suitable for cosmetic materials, etc., by carrying out the addition polymerization of diglycerol with propylene oxide and then adding tocopherol thereto before and/or after deodorization. SOLUTION: The addition polymerization of 1mol diglycerol with preferably 4-30mol propylene oxide is initially carried out and tocopherols (e.g. α-tocopherol) in an amount of preferably 0.01-0.1wt.% based on the polyoxypropylene diglyceryl ether are then added thereto before and/or after carrying out the deodorization. The deodorization is preferably conducted by a method for adding water thereto and distilling off the water under atmospheric pressure or a reduced pressure, etc. The distilling off temperature for the water is preferably 50-120 deg.C and the water is preferably used in an amount of 2-100 pts.wt. based on 100 pts.wt. polyoxypropylene diglyceryl ether.
Increasing evidence suggests bats are the ancestral hosts of the majority of coronaviruses. In general, coronaviruses primarily target the gastrointestinal system, while some strains, especially Betacoronaviruses with the most relevant representatives SARS-CoV, MERS-CoV, and SARS-CoV-2, also cause severe respiratory disease in humans and other mammals. We previously reported the susceptibility of Rousettus aegyptiacus (Egyptian fruit bats) to intranasal SARS-CoV-2 infection. Here, we compared their permissiveness to an oral infection versus respiratory challenge (intranasal or orotracheal) by assessing virus shedding, host immune responses, tissue-specific pathology, and physiological parameters. While respiratory challenge with a moderate infection dose of 1 × 104 TCID50 caused a systemic infection with oral and nasal shedding of replication-competent virus, the oral challenge only induced nasal shedding of low levels of viral RNA. Even after a challenge with a higher infection dose of 1 × 106 TCID50, no replication-competent virus was detectable in any of the samples of the orally challenged bats. We postulate that SARS-CoV-2 is inactivated by HCl and digested by pepsin in the stomach of R. aegyptiacus, thereby decreasing the efficiency of an oral infection. Therefore, fecal shedding of RNA seems to depend on systemic dissemination upon respiratory infection. These findings may influence our general understanding of the pathophysiology of coronavirus infections in bats.
Patients receive berzosertib IV over 60 minutes BIW for 5 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo RT 5 days a week for 5-6 weeks depending on the type of surgery undergone. Patients also undergo a collection of blood on study.