anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND AIMS: Clinical deterioration within the first 24 h of patient admission triggering a Medical Emergency Team (MET) call is a common occurrence. A greater understanding of these events, with a focus on the recognition and management of sepsis, could lead to quality improvement interventions.
METHODS: A retrospective observational review of general and subspecialty medical admissions triggering a MET call within 24 h of admission at a quaternary Australian hospital.
RESULTS: 2648 MET calls occurred (47.9/1000 admissions), 527 (20% of total MET events, 9.5/1000 admissions) within 24 h of admission, with the trigger more likely to be hypotension (odds ratio: 1.5, P = 0.0013). There were 263 MET calls to 217 individual medical patients within 24 h of admission, of which 84 (38.7%) were admitted with suspected infection, 69% of which fulfilled sepsis criteria. Of these, 36.2% received antimicrobial therapy within the recommended timeframe and 39.6% received antibiotics in line with hospital guidelines. Sepsis was initially missed in 11% of patients. Afferent limb failure occurred in 29% of patients with 40.5% experiencing a failure of the ward-based response to deterioration prior to MET call. Median hospital length of stay was increased in patients admitted with suspected infection (7 vs 5 days, P = 0.015) and in those with sepsis not receiving antimicrobial therapy within guideline timeframes (9 vs 4 days, P = 0.017).
CONCLUSION: There is a significant opportunity to improve care for patients who trigger a MET within 24 h of admission. This study supports the implementation of a hospital sepsis management guideline.
Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD). For example, provided herein are screening methods for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. The screening method can be an in vitro screening method or an in vivo screening method, e.g., using an animal model described herein. Animal models are also provided herein, for example, for screening candidate therapeutics for treating or preventing eye diseases, such as AMD. Methods of preparing the animal models are also described herein. Methods of treating or preventing AMD are also provided.
FIELD: medicine, obstetrics. SUBSTANCE: one should carry out dopplerometric assay to determine resistance indices of circulation rates curves (CRC) in fetal middle cerebral artery (MCA) both before and after pharmacological sampling at addition of trental. At decreased resistance indices of CRC in fetal MCA one should conduct delivery through natural parturient canal, and at increased resistance indices of CRC in fetal MCA it is necessary to choose Caesarean operation. Trental addition is carried out intravenously by drops at dilution of 5 ml trental/200 ml physiological solution. The method enables to increase accuracy in choosing the tactics of delivery. EFFECT: higher efficiency of choice. 1 cl, 2 ex, 4 tbl
Adoption of healthy lifestyles by all persons is critical for the prevention of high BP and is an indispensable part of the management of those with hypertension. Weight loss of as little as 10 lbs (4.5 kg) reduces BP and/or prevents hypertension in a large proportion of overweight persons, although the ideal is to maintain normal body weight. BP is also benefited by adoption of the Dietary approaches to Stop Hypertension (DASH) eating plan which is a diet rich in fruits, vegetables, and low fat dairy products with a reduced content of dietary cholesterol as well as saturated and total fat (modification of whole diet). It is rich in potassium and calcium content. Dietary sodium should be reduced to no more than 100 mmol per day (2.4 g of sodium). Everyone who is able should engage in regular aerobic physical activity such as brisk walking at least 30 minutes per day most days of the week. Lifestyle modifications reduce BP, prevent or delay the incidence of hypertension, enhance antihypertensive drug efficacy and decrease cardiovascular risk. For example, in some individuals, a 1,600 mg sodium DASH eating plan has BP effects similar to single drug therapy. Combinations of two (or more) lifestyle modifications can achieve even better results. For overall cardiovascular risk reduction, patients should be strongly counseled to quit smoking.

Lifestyle modification involves altering long-term habits, typically of eating or physical activity, and maintaining the new behavior for months or years. Lifestyle changes are a more natural way toward therapeutic goals and should be an integral component of halting or even reversing early vascular aging as in pre hypertensive subjects. From a public health perspective, even a small reduction in BP should have a tremendous, beneficial effect on the occurrence of hypertension and its complications. In view of the current epidemic of BP-related diseases and the proven effects of lifestyle modifications on BP, the current challenge to health care providers, researchers, and public officials is to develop and implement effective life style intervention program comprising exercise dietary and educative component in clinical and public health strategies that achieve and maintain healthy lifestyle modification
Methods, computer systems, and computer readable medium for testing a plurality of models in order to classify a biological specimen. A determination is made as to whether a model precondition associated with a model in the plurality of models has been satisfied. The model is skipped when the model precondition has not been satisfied. When the model precondition has been satisfied, the first model is tested by selecting a calculation from the first model. The selected calculation is computed using cellular constituent abundance values from the biological specimen in accordance with a calculation algorithm set forth in the selected model. This selecting and computing is repeated for one or more calculations in the selected model. Then, each of these calculations is aggregated in accordance with an aggregation algorithm associated with the selected model. These steps are repeated for at least one other model in the plurality of models. A computer medium comprising a classifier for classifying a biological specimen into a biological sample class that includes one or more models. Each of the one or more models comprises (i) an optional model precondition, (ii) a calculation algorithm, (iii) a plurality of calculations, and (iv) a calculation aggregation algorithm.
The present invention is a diagnosis support system providing automated guidance to a user by automated retrieval of similar disease images and user feedback. High resolution standardized labeled and unlabeled, annotated and non-annotated images of diseased tissue in a database are clustered, preferably with expert feedback. An image retrieval application automatically computes image signatures for a query image and a representative image from each cluster, by segmenting the images into regions and extracting image features in the regions to produce feature vectors, and then comparing the feature vectors using a similarity measure. Preferably the features of the image signatures are extended beyond shape, color and texture of regions, by features specific to the disease. Optionally, the most discriminative features are used in creating the image signatures. A list of the most similar images is returned in response to a query. Keyword query is also supported.
The present invention discloses a method for preparing semen momordicae seed extract containing triterpene saponin components. After the traditional Chinese medicine of semen momordicae is pulverized, reflux extraction is carried out by ethanol, and fat-soluble components are removed by ethyl ether extraction. Components which do not dissolve in normal butyl alcohol are removed by the extraction of normal butyl alcohol, purification is carried out by adsorptive macroporous resin, and light yellow semen momordicae extract powder which has fresh fragrance is obtained. Physical and chemical analysis and hemolytic experiments show that the extract contains triterpene saponin components. The semen momordicae extract containing triterpene saponin components, which is obtained by the present invention, has low toxicity. Mouses, pigs and cattle do not have partial stimulation after intramuscular injection. Oral administration and injection application are safe. The present invention has broad application prospects in the field of vaccine production.
FIELD: biotechnology. SUBSTANCE: invention aims to selectively eliminate cells infected with hepatitis C virus or infection RNA thereof. For that, into cells is introduced plasmid pcDT encoding pseudo hepatitis C virus "-" RNA and capable of orienting synthesis of A subunit of diphtheria toxin in hepatitis C virus-infected cells. Such RNA does not kill sound cells and is incapable of translation. EFFECT: enlarged resource for preparing antihepatitis vaccines. 3 cl, 1 dwg
Neoadjuvant chemotherapy plus camrelizumab for ⅠB1 Cervical Cancer. Patients first received one cycle of platinum-based doublet priming chemotherapy. After 3 weeks, participants subsequently received two cycles of the PD-1 inhibitor camrelizumab combined with chemotherapy every 3 weeks. The study will be conducted in two stages: (1) Patients enrolled in the first stage with tumors ≤2 cm and no new lesions after completion of treatment will undergo cone biopsy + pelvic lymphadenectomy or SLN mapping. Those who meet ConCerv criteria will undergo a second TCT, human papillomavirus (HPV) and colposcope 3 months later, and those who do not meet ConCerV criteria will undergo radical cervical surgery. (2) Patients enrolled in the second stage with tumors ≤2 cm and no new lesions underwent cervical biopsy + pelvic lymphadenectomy or SLN mapping; patients with LSIL on biopsy underwent TCT, HPV, and colposcope 3 months later; if biopsy suggests HSIL and above, perform cone biopsy.
BACKGROUND AND OBJECTIVES: Patient-reported measures of encounters in healthcare settings and consideration of their preferences could provide valuable inputs to improve healthcare quality. Although there are increasing reports of user experiences regarding health care in India in recent times, there is a lack of evidence from Indian healthcare settings on the care provided for patients with chronic diseases.
METHODS: We selected diabetes mellitus and cancer as representatives of two common conditions requiring different care pathways. We conducted a scoping review of studies reporting experiences or preferences of patients/caregivers for these conditions, in PubMed, Global Index Medicus and grey literature, from the year 2000 onwards. Both published and emergent themes were derived from the data and summarised as a narrative synthesis.
RESULTS: Of 95 included studies (49 diabetes, 46 cancer), 73% (65) were exclusively quantitative surveys, 79% included only patients (75), and 59.5% (44) were conducted in government centres. Studies were concentrated in a few states in India, with the underrepresentation of vulnerable population groups and representative studies. There was a lack of standardised tools and comprehensive approaches for assessing experiences and preferences of patients and caregivers, concerning diabetes and cancers in India. The commonest type of care assessed was therapeutic (74), with 14 cancer studies on diagnosis and nine on palliative care. Repeated visits to crowded centres, drug refill issues, unavailability of specific services in government facilities, and expensive private care characterised diabetes care, while cancer care involved delayed diagnosis and treatment, communication, and pain management issues.
CONCLUSIONS: There is a need for robust approaches and standardised tools to measure responsiveness of the healthcare system to patient needs, across geographical and population subgroups in India. Health system reforms are needed to improve access to high-quality care for treatment and palliation of cancer and management of chronic diseases such as diabetes.
539,089. Vitamin concentrates. DISTILLATION PRODUCTS, Inc. June 15, 1940, No. 10417. Convention date, Oct. 14, 1939. [Class 2 (iii)] [Also in Group III] Oil is extracted from fish tissue by means of a low vapour pressure solvent (that is a solvent having a boiling-point above 78‹C. at 1 mm. pressure) which may be a natural vegetable or animal oil, containing anti-oxidant, or a fish oil residue from which the vitamin fraction has been distilled off, or a hydrocarbon oil. The solvent may be distilled off from the extract under high vacuum, leaving the fish oil containing vitamins and anti-oxidant. If desired the extractant oils may contain other vitamins so that the final product when a vitamin concentrate is desired, may contain vitamins A and E, E and K, or A, D, E and K ; the last-named being obtained from halibut or tuna liver by extraction with a mixture of soya and wheatgerm oils and subsequent high vacuum distillation. In examples (1) ski-jack livers after treatment with alkali in a known manner are extracted with soya oil from which 10 per cent. of its weight has been removed by high vacuum distillation ; (2) soup-fin shark livers are treated as in example (1) but with sardine oil residue mixed with crude corn oil as solvent; (3) halibut livers are extracted with sesame oil, a vitamin A concentrate being if desired separated from the extract by high-vacuum distillation ; (4) blue-fin tuna livers are extracted with a petroleum fraction boiling at 100-200‹C. at 0.1 mm. pressure mixed with crude corn oil, the extract being distilled in a high-vacuum still to remove the solvent mineral oil, and if desired the residual oil is again distilled to separate a vitamin A and D concentrate.
Adverse reactions reported in controlled clinical trials and long-term open studies in 595 patients treated with Flunisolide Nasal Solution are described below. Of these patients, 409 were treated for 3 months or longer, 323 for 6 months or longer, 259 for 1 year or longer, and 91 for 2 years or longer.

In general, side effects elicited in the clinical studies have been primarily associated with the nasal mucous membranes. The most frequent complaints were those of mild transient nasal burning and stinging, which were reported in approximately 45% of the patients treated with Flunisolide Nasal Solution in placebo-controlled and long-term studies. These complaints do not usually interfere with treatment; in only 3% of patients was it necessary to decrease dosage or stop treatment because of these symptoms. Approximately the same incidence of mild transient nasal burning and stinging was reported in patients on placebo as was reported in patients treated with Flunisolide Nasal Solution in controlled studies, implying that these complaints may be related to the vehicle or the delivery system. The incidence of complaints of nasal burning and stinging decreased with increasing duration of treatment.

Other side effects reported at a frequency of 5% or less were: nasal congestion, sneezing, epistaxis and/or bloody mucous, nasal irritation, watery eyes, sore throat, nausea and/or vomiting, and headaches. As with other nasally inhaled corticosteroids, nasal septal perforations have been reported in rare instances with the use of Flunisolide Nasal Solutions. Temporary or permanent loss of the sense of smell and taste have also been reported with the use of flunisolide nasal solutions.

Systemic corticosteroid side effects were not reported during the controlled clinical trials. If recommended doses are exceeded, or if individuals are particularly sensitive, symptoms of hypercorticism, i.e., Cushing’s syndrome, could occur. Cases of growth suppression have been reported for intranasal corticosteroids (including Flunisolide Nasal Solution) ( see PRECAUTIONS, Pediatric Use). 

To report SUSPECTED ADVERSE REACTIONS, contact Bausch & Lomb Incorporated at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Influenza is acute inflammation of upper respiratory tracts caused by viruses. Influenza usually happens during the period of climate change. Influenza has strong epidemicity, and has the symptoms of acute occurrence, high fever, sensation of chill, headache, nasal obstruction, a large amount of snot, and red and swollen and sore throat, occasionally having the symptoms of sickness, vomiting, and severe coughing. The proved recipe adopts Chinese medicine herbals as the raw materials, and oral liquid is obtained by a traditional decoction method. The proved recipe treats the disease according to the pathogenesis of the disease, has no side or toxic effects, and has a unique curative effect on influenza having the symptoms of high fever, sensation of chill, headache, nasal obstruction, running nose, inflammation and ache of throat, sickness, vomiting, and coughing. The proved recipe has been repeatedly researched over the several years, on the basis of curing of influenza patients over the past decades, the curative effect of the proved prescribe has been observed in clinic, the total effective rate reached 96%, and the cure rate arrives at 92%. The proved prescribe for treating influenza has a strong influenza resistant effect, and a prominent curative effect on preventing influenza, is capable of strengthening the bacterium and virus resistance and immunity of human bodies, has the advantages of short treatment course, rapid effect, good consolidation, and user-friendliness, and is the only overall therapeutic proved prescribe for treating and preventing influenza.
An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition. Proanthocyanidin can act as a cross-linker and as a protector of elastin against UV degradation. Proanthocyanidin combined with a collagen or gelatin-hyaluronic acid matrix can inhibit matrix degradation and contraction with fibroblasts. Additionally, the present invention encompasses a method for augmenting the volume area of dermal tissue at sites where wrinkles and other tissue imperfections have caused visible changes associated with loss or rearrangement of the subcutaneous collagen network comprising the step of: providing an effective amount of a composition, which can be injected locally, and which consists of a mixture of macromolecules which are native constituents of the skin, the mixture comprising collagen, elastin and hyaluronic acid, which are held together by covalent, ionic or hydrogen bonds, and which include natural materials which have been demonstrated to increase the natural synthesis of these molecules by cells which reside in the dermis.
Subjects with Bipolar Disorder, Mania receive an extended-release form of clonidine on the second day of this 3-day study. Rating scales, record of sleep, and a questionnaire of adverse effects is recorded on each of the three days.
Corticosteroids are thought to act at least in part, by controlling the rate of synthesis of proteins. Although there are a number of instances in which the synthesis of specific proteins is known to be induced by corticosteroids, the links between the initial actions of the hormones and the final metabolic effects have not been completely elucidated. 

The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions. The consequence of these three primary effects together with similar actions on cation transport in other tissues appear to account for the entire spectrum of physiological activities that are characteristic of mineralocorticoids. In small oral doses, fludrocortisone acetate produces marked sodium retention and increased urinary potassium excretion. It also causes a rise in blood pressure, apparently because of these effects on electrolyte levels. 

In larger doses, fludrocortisone acetate inhibits endogenous adrenal cortical secretion, thymic activity, and pituitary corticotropin excretion; promotes the deposition of liver glycogen; and, unless protein intake is adequate, induces negative nitrogen balance. 

The approximate plasma half-life of fludrocortisone (fluorohydrocortisone) is 3.5 hours or more and the biological half-life is 18 to 36 hours.
This study seeks to enhance the management of HF patients by demonstrating that follow-up and medication up-titration can be effectively carried out digitally at home, thereby relieving the burden on healthcare systems and patients. There exists a substantial knowledge gap in the implementation of life-saving HF drugs that have been shown to significantly reduce mortality in HF patients, by as much as 73%. Despite strong evidence from clinical trials and guidelines, the utilization of optimal HF therapy among patients remains low. The successful STRONG-HF trial demonstrated improved outcomes through early and rapid up-titration of HF medications and follow-up at specialized HF clinics after discharge, and this strategy is now strongly recommended in the updated European Society of Cardiology Heart Failure Guidelines from 2023. However, a major challenge was the need for patients to travel to the hospital for weekly visits, which posed significant barriers for many patients, especially in geographically dispersed regions due to travel distance, immobility, and logistical challenges. To address this gap, the STRONG@HOME trial aims to conduct visits and rapid up-titration of medications in the patient's home, a strategy not previously tested in a clinical trial and with direct clinical implications. The success of this approach has the potential to improve HF care globally and advance the field of implementation science in HF and other chronic diseases.
The invention discloses a lagerstroemia speciosa mask. The lagerstroemia speciosa mask is made of lagerstroemia speciosa extractives, polyving akohol, 1,2-propylene glycol, silicone oil, ethanol, vinyl acetate, perfume and ionized water. Raw materials of components of the mask have the good synergy function; the skin can be conditioned; and the good freckle removing effect is achieved. Clinical research experiments show that the effective freckle removing rate reaches 84.85%. In addition, the lagerstroemia speciosa mask further has the effects of moisture preservation, skin whitening and anaphylaxis prevention. The lagerstroemia speciosa mask is simple in manufacturing method, natural in raw material, low in cost and obvious in effect; and the good application prospect is achieved.
In the study group that will be made to smell the scent of breast milk, the procedures for the scent of the mother will be carried out in the same way, and 20 drops of each baby's own mother's milk will be dropped onto the diaper (4). The cover, which has the scent of breast milk, will be placed 15 cm away from the baby and allowed to smell it from 5 minutes before to 5 minutes after the heel prick blood collection attempt. The baby's pain score will be evaluated by the observing nurse according to the NIPS pain scale 5 minutes before, during and 5 minutes after the procedure.
In the conventional treatment group, non-surgical standard treatment of burn scars except for pressure monitoring was performed in the same manner. Subjects were instructed to wear the garment 23 hours per day, removing them only for bathing.