anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: The current study is a Phase I clinical study with the goal of determining feasibility and the effectiveness of the Kaufman Speech to Language Protocol (K-SLP) for children with childhood apraxia of speech (CAS) and comorbidities. We hypothesized that K-SLP intervention would result in improved outcomes and maintenance of treatment effect at 3-4 months postintervention.
METHOD: Single-subject experimental design with multiple baselines across behaviors was replicated across a group of six children. Five out of six participants completed the study. The K-SLP intervention was administered in dyads four times a week for three consecutive weeks. Outcomes included assessment of word/syllable shapes, articulation accuracy, speech intelligibility, and functional communication. Treatment progress was measured through: (a) the administration of custom probe word lists and (b) assessments carried out at pretreatment, immediately following intervention and approximately 3-4 months after the study period.
RESULTS: Four out of five participants demonstrated significant improvements to words targeted in treatment and three out of five generalized these to untreated words. Furthermore, three out of five participants showed immediate and clinically significant posttreatment improvements in speech intelligibility and functional outcomes, and this increased to four out of five participants at 3-4 months follow-up.
CONCLUSIONS: The study provides preliminary support for the effectiveness of the K-SLP program when delivered in dyads to children with CAS with comorbidities. The study replicates earlier findings and reaffirms the positive outcomes of K-SLP for children with CAS.
PURPOSE: A pharmaceutical formulation for treating gastrointestinal diseases containing sodium alginate mixture is provided to ensure high viscosity regulation effect and gastrointestine protection effect. CONSTITUTION: A pharmaceutical formulation for treating gastrointestine diseases contains 500-3,500 of low molecular weight of sodium alginate and 40,000-110,000 of high molecular weight of sodium alginate in 3-7:3-7 ratio(v/v). The final viscosity of the sodium alginate is 150~160 cps. The pharmaceutical formulation contains 0.1-30 weight% of sodium alginate mixture. The pharmaceutical formulation is used in the form of liquid, suspension, or emulsion. A method for manufacturing the pharmaceutical formulation comprises: a first step of dissolving low molecular weight of sodium alginate in 1-10% of distilled water to obtain sodium alginate solution having low viscosity; a second step of dissolving high molecular weight of sodium alginate in 1-10% of distilled water to obtain sodium alginate solution having high viscosity; and a step of mixing the solution in 3-7:3-7 ratio.
The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling HIV replication and is an important part of the ultimate failure to eradicate the virus. Disclosed herein are methods for genetically enhancing the HIV-specific CTL response to allow long-term viral suppression or viral clearance. Human hematopoietic stem cells (HSCs) were genetically modified such that they differentiate into mature CTLs that will kill HIV infected cells. As disclosed herein, the functional effector cells are not human leukocyte antigen (HLA)-restricted. As disclosed herein, stem cells are transduced with non-HLA restricted chimeric antigen receptors (CARs) that allow the recognition of HIV or HIV-infected cells when expressed by a CTL. These CARs are hybrid molecules that contain an extracellular HIV recognition domain and an intracellular TCR-zeta signaling domain. The CTL response may be enhanced through the targeting of T cell inhibitory receptors. The methods and compositions disclosed herein may be used to engineer antiviral immunity and HIV-specific CTL responses in vivo. Also disclosed herein are methods and compositions for the treatment of chronic viral infections such as HIV.
BACKGROUND: Biosampling studies in critically ill patients traditionally involve bedside collection of samples followed by local processing (ie. centrifugation, aliquotting, and freezing) and storage. However, community hospitals, which care for the majority of Canadian patients, often lack the infrastructure for local processing and storage of specimens. A potential solution is a "simplified" biosampling protocol whereby blood samples are collected at the bedside and then shipped to a central site for processing and storage. One potential limitation of this approach is that delayed processing may alter sample characteristics.
OBJECTIVE: To determine whether delays in blood sample processing affect the stability of cytokines (IL-6, TNF, IL-10, IFN-γ), chemokines (IL-8, IP-10, MCP-1, MCP-4, MIP-1α, MIP-1β), cell-free DNA (cfDNA) (released by dying cells), and blood clotting potential in human blood samples.
METHODS: Venous blood was collected into EDTA and citrate sample tubes and stored at room temperature (RT) or 4°C for progressive intervals up to 72 hours, prior to processing. Plasma cytokines and chemokines were quantified using single or multiplex immunoassays. cfDNA was measured using Picogreen DNA Quantification. Blood clotting potential was measured using a thrombin generation assay.
RESULTS: Blood samples were collected from 9 intensive care unit (ICU) patients and 7 healthy volunteers. Admission diagnoses for the ICU patients included sepsis, trauma, ruptured abdominal aortic aneurysm, intracranial hemorrhage, gastrointestinal bleed, and hyperkalemia. After pre-processing delays of up to 72 hours at RT or 4°C, no significant changes were observed in plasma cytokines, chemokines, cfDNA, or thrombin formation.
CONCLUSIONS: Delayed sample processing for up to 72 hours at either RT or 4°C did not significantly affect cytokines, chemokines, cfDNA, or blood clotting potential in plasma samples from healthy volunteers and ICU patients. A "simplified" biosampling protocol is a feasible solution for conducting biosampling research at hospitals without local processing capacity.
The invention provides a preparation method of a traditional Chinese medicine for treating oily food overeating type hypochondriac pain, and belongs to the technical field of preparation methods of traditional Chinese medicines. Currently, acetylsalicylic acid is generally adopted to treat oily food overeating type hypochondriac pain, has gastrointestinal reactions, such as inappetence, nausea and emesis when being taken large dose, can cause alimentary tract hemorrhage in a serious condition, and can induce and aggravate peptic ulcer. The preparation method is characterized by comprising the following steps of immersing the following 19 traditional Chinese medicines in water, namely malt, rice sprout, chicken gizzard-membrane, buckwheat, medicated leaven, radish seed, papaya, quince, radix bupleuri, rhizoma cyperi, costustoot, three-nerved spicebush root, dried tangerine peel, green tangerine peel, immature bitter orange, mangnolia officinalis, fructus amomi, fingered citron and liquorice; and decocting with slow fire to obtain decoction which is the traditional Chinese medicine for treating oily food overeating type hypochondriac pain. The traditional Chinese medicine has the advantages of simple manufacture, small toxic and side effect of prepared Chinese medicine decoction, short course of treatment and high cure rate. Monarch, minister, assistant and guide medicines are compatible. Adverse reactions, allergy reactions and toxic reactions caused by Western medicaments sulfonamides and antibiotics can be avoided while the traditional Chinese medicine is administrated.
PURPOSE:To offer a sanitary earphone at all times by providing an antimicrobial agent at least on the surface of an ear pad. CONSTITUTION:The ear pad part 5 is held in a state wherein the antimicrobial agent is dispersed uniformly in a continuous air bubble type foamed body of, for example, polyurethane or silicone rubber. This antimicrobial agent consists of zeolite particulates which carry metallic ions having antimicrobial operation such as silver ions, copper ions and zinc ions by ion exchanging. Synthetic zeolite is used as this zeolite. Further, compounds such as benzoic acid, salicylic acid, parachlorometacresol, resorcinol, etc., are usable as the antimicrobial agent. Consequently, the multiplication of various germs nearby the auricle can be suppressed or positive disinfection is enabled to offer the sanitary earphone at all times.
Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apoptosis or senescence. Although cellular senescence contributes to wound healing, its persistence inhibits growth. Therefore, we hypothesized that cellular senescence contributes to BPD progression. Human autopsy lungs were obtained. Sprague-Dawley rat pups exposed to 95% oxygen between Postnatal Day 1 (P1) and P10 were used as the BPD phenotype. N-acetyl-lysyltyrosylcysteine-amide (KYC), tauroursodeoxycholic acid (TUDCA), and Foxo4 dri were administered intraperitoneally to mitigate myeloperoxidase oxidant generation, ER stress, and cellular senescence, respectively. Lungs were examined by histology, transcriptomics, and immunoblotting. Cellular senescence increased in rat and human BPD lungs, as evidenced by increased oxidative DNA damage, tumor suppressors, GL-13 stain, and inflammatory cytokines with decreased cell proliferation and lamin B expression. Cellular senescence-related transcripts in BPD rat lungs were enriched at P10 and P21. Single-cell RNA sequencing showed increased cellular senescence in several cell types, including type 2 alveolar cells. In addition, Foxo4-p53 binding increased in BPD rat lungs. Daily TUDCA or KYC, administered intraperitoneally, effectively decreased cellular senescence, improved alveolar complexity, and partially maintained the numbers of type 2 alveolar cells. Foxo4 dri administered at P4, P6, P8, and P10 led to outcomes similar to TUDCA and KYC. Our data suggest that cellular senescence plays an essential role in BPD after initial inducement by hyperoxia. Reducing myeloperoxidase toxic oxidant production, ER stress, and attenuating cellular senescence are potential therapeutic strategies for halting BPD progression.
<P>PROBLEM TO BE SOLVED: To provide a hair grower exhibiting excellent hair-growing effect without using any synthetic chemicals or preservatives, thickening thinned hair, seldom causing downy hair loss, and having sustainable effect.  <P>SOLUTION: The powdery hair grower is such as to be used by being mixed into a liquid prior to use to make a liquid-mixed hair grower, which is applied to the scalp and the hair. This powdery hair grower comprises one or more kinds of powder selected from naturally-occurring polymer's powder and ceramic powder. After the liquid-mixed hair grower is applied to the scalp and the hair and evaporated to dryness, secreted matter on the surface of the scalp and the hair runs adhered to the powder. In this powdery hair grower, the naturally-occurring polymer's powder may be derived from one or more kinds selected from rice, black rice, herb, aloe's mesophyll, citrus rind, purple potato and soybean.  <P>COPYRIGHT: (C)2008,JPO&INPIT
A pH response type vitamin E drug-loaded material, a preparation method and application thereof. Specifically, the material is prepared by taking epsilon-caprolactone, allyl polyoxyethylene ether and 2-methylamine ethanethiol as starting materials through ring-opening polymerization and mercaptoalkene click reaction, and is shown as a formula I. The molecular main chain is composed of a hydrophilic chain segment of polyoxyethylene ether and a hydrophobic chain segment of polycaprolactone, and the structure endows the amphiphilic polymer with good water/oil amphiphilic performance, can be self-assembled to form micelles, and is suitable for being used as an entrapment material of a fat-soluble medicine. In addition, the dimethylamino group at the molecular chain end has the effect of protonation in a weakly acidic (pH 6.0-7.0) environment. The cytotoxicity experiment shows that the polymer has no obvious cytotoxicity; the results of dynamic light scattering, transmission electron microscopy and the like show that the material can be self-assembled to entrap vitamin E to form nano particles of about 50-120 nm, and the entrapment rate reaches 82.2%. These results show that the copolymer carrier obtained based on 2-methylamine ethanethiol click has application prospects in antineoplastic drugs.
The group will be given Transverse Friction Massage twice a week for 4 weeks. Transverse friction massage will be applied to each tense muscle group and trigger points for 3-5 minutes, crossing the direction of the pelvic floor muscle fibers. Massage duration is approximately 30 minutes for each session.
Matching placebo capsules will be administered orally as a single daily dose on days 1 through 14 with water. On days 1, 7, and 14, matching placebo capsules will be administered with food. On days 2-6 and 8-13, matching placebo will be administered under fed conditions.
Participation in the study will include one study visit of approximately 2.5 hours. If possible, the study visit will be combined with a regular follow-up visit. Vena puncture is the only invasive procedure, with low risk of adverse effects. Blood will be drawn after an overnight fast. To minimize the duration of the visit, patients will be offered to fill out the questionnaires at home. Individual adverse test results will be reported to a participants' treating physician to enable treatment or follow-up as indicated. The results of the full study group will be used to guide future interventions and support for melanoma and NSCLC patients.
BACKGROUND: Circular RNAs (circRNAs) have been reported to play important roles in cancers. Here, we characterized circVMP1 (hsa_circ_0006508), an important circRNA which promoted glycolysis and disease progression in colorectal cancer (CRC). In this study, we aimed to explore the mechanism by which circVMP1 regulated tumor glycolysis and its related pathways in promoting CRC cell proliferation and metastasis.
METHODS: The expression level of circVMP1 in CRC tissues and adjacent normal tissues was detected using quantitative PCR. In vitro and in vivo functional experiments were used to evaluate the effects of circVMP1 in the regulation of CRC cell proliferation and migration. Mitochondrial stress tests and glycolysis stress tests were conducted to detect the effect of circVMP1 on oxidative phosphorylation and glycolysis. Dual-luciferase reporter and RNA immunoprecipitation assays were used to evaluate the interaction between circVMP1, miR-3167, and HKDC1.
RESULTS: We demonstrated that the level of circVMP1 was significantly upregulated in CRC tissues compared with normal tissues. In HCT116 and SW480 cells, overexpression of circVMP1 promoted proliferation, metastasis, and glycolysis. In vivo analysis indicated that circVMP1 accelerated the proliferation of xenograft tumors. As for the mechanism, overexpression of circVMP1 increased the levels of hexokinase domain component 1 (HKDC1) through competitive binding with miR-3167.
CONCLUSION: Our study reported that circVMP1 was one of the tumor driver genes that promoted CRC malignant progression and glycolysis by upregulating HKDC1. CircVMP1/miR-3167/HKDC1 was a signaling axis that might be a target for CRC therapy.
<P>PROBLEM TO BE SOLVED: To obtain an antioxidant with high safety and an antioxidant skin care preparation mixed with the same.  <P>SOLUTION: The antioxidant comprises an extract of one or more kinds of Basidiomycetes selected from Laetiporus sulphureus, Ramaria botrytis, Panellus serotinus and Phaeolepiota aurea as an active ingredient. The antioxidant skin care preparation comprises an extract of one or more kinds of Basidiomycetes selected from Laetiporus sulphureus, Ramaria botrytis, Panellus serotinus and Phaeolepiota aurea as an active ingredient. Laetiporus sulphureus strain deposited as accession number FERM P-20083 is preferable as Laetiporus sulphureus and Panellus serotinus strain deposited as accession number FERM P-20115 is preferable as the Panellus serotinus. The extract from the Basidiomycetes has excellent free radical scavenging ability and is useful as an antioxidant. The mushroom of the Basidiomycetes is widely used for food and highly safe so that it is preferably formulated with a skin care preparation.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
This is a multicenter, controlled, prospective, randomized non-inferiority study comparing operative treatment to non-operative treatment of over 3 mm dislocated pediatric medial epicondyle fractures without joint incarceration or ulnar nerve dysfunction. A total of 120 patients will be randomized in 1:1 ratio to either operative or non-operative treatment. The study will have a parallel non-randomized patient preference arm. Non-operative treatment will be upper limb immobilization with long arm cast for 4 weeks. Operative treatment will be open reduction and internal fixation (ORIF). Data is collected at baseline and at each follow-up up to 2 years. Quick-DASH is used as primary outcome measure. Secondary outcomes are patient reported pain, differences in range of motion, PedsQL Life inventory questionnaire as well as Mayo elbow preformance score.
PE is a brief cognitive behavioral therapy that can ameliorate symptoms of PTSD, depression, and anxiety in survivors of various types of trauma. PE has been successfully implemented by counselors at a community rape crisis clinic (Women Organized Against Rape \[WOAR\]) who received extensive training and weekly supervision from PE experts. Such extensive expert involvement is not a practical model for long-term clinical practice in a community-based clinic. Therefore, Part 1 of this study will examine whether counselors at WOAR can maintain their PE implementation success with reduced expert involvement. In Part 2 of this study, PE will be implemented by counselors at another community clinic (Joseph J. Peters Institute \[JJPI\]) to examine its effectiveness in treating PTSD and to determine the generalizability of training procedures.

Participants in this study are randomly assigned to either PE or to individual and group therapy. Treatment sessions are conducted weekly for 10 to 20 weeks, based on participants' rates of improvement. Participants are assessed before treatment, after 10 weeks, and again in the follow-up phase at 3, 6, 12, and 24 months post-treatment.
Bipolar disorder has a high hospitalization rate, suicide rate and disability rate, and cognitive dysfunction is one of the core clinical symptoms of bipolar disorder. Cognitive recovery has become a new target and a new target for clinical treatment. In recent years, gut microbiome has been recognized as one of the neuropathological mechanisms of bipolar disorder. This study aims to study the effect of probiotics on cognitive function in stable bipolar disorder patients and the possible mechanism of action. A total of 100 patients with stable bipolar disorder were enrolled into the control group and the experimental group in a random double-blind way. This study was designed as a randomized double-blind controlled study. The enrolled subjects were randomized into two groups: intervention group and waiting intervention group. The intervention group received 12 weeks of probiotic intervention from the start of the study, and the waiting group received 12 weeks of placebo intervention from the start of the study. At the start of the study, both groups received 12 weeks of probiotic intervention. This study to compare the dynamic changes of cognitive function and resting brain network in stable bipolar disorder patients before and after using probiotics, and to compare the changes of physical symptoms, sleep and serum cortisol levels in stable bipolar disorder patients before and after the use of probiotics between the two groups, and further explore the possible mechanism of action of the experimental drug.
This group will be prescribed tamsulosin and standard narcotic pain medication. Patients will be given tamsulosin 0.4mg at bedtime. This dosage has been used in other studies for children age ≥ 4.
Ampicillin 2g/4h plus ceftriaxone 2g/12h intermittent infusion. The duration of treatment will be 42 days.
This study aimed to examine the effect of visual pre-cueing presented at different time intervals in the response time of dyslexic and non-dyslexic children. Fifteen dyslexic and 15 non-dyslexic children performed a computerised four-choice reaction time task across four conditions: no pre-cue and a 43-ms time interval (or duration) of a centralised dot appearing in the stimulus circle at 43, 86 or 129 ms prior to the stimulus. Each condition was repeated eight times, totaling 32 trials, and presented in a random order. Response correctness and response times were recorded for each trial, and z-scores were obtained by standardising performance in the three pre-cued conditions relative to the no pre-cue condition. Dyslexic children took longer to respond in the task than non-dyslexic children. Both dyslexic and non-dyslexic children had faster response times in the pre-cued conditions than in the conditions without the pre-cue. These lower response times were inversely correlated with the length of the pre-cueing interval. These results suggest that dyslexic children use visual pre-cueing to improve decision-making. The ability of dyslexic children to use pre-cues may offer an interesting avenue for the exploration of interventions aimed at minimising behavioural and cognitive difficulties resulting from dyslexia.
This was a multicenter, prospective, parallel-grouping, randomized controlled clinical study comparing low FiO2 (40%) and high FiO2 (80%) levels in older patients undergoing laparoscopic gastrointestinal surgery. the investigators planned to enroll 1098 subjects aged \> 65 years for laparoscopic gastrointestinal surgery at 19 clinical trial centers in China, randomized in a 1:1 ratio, to use two inhaled oxygen concentrations during surgery. All patients will be performed via the lung-protective ventilation strategy. The respiratory parameters are VT: 6-8ml/kg, PEEP: 6-8 cmh2O, RR: 1:2, and respiratory rate will be adjusted by maintaining a partial pressure of carbon dioxide at 35-45 mmHg. Manual lung recruitment maneuvers will be performed after tracheal intubation and before tracheal extubation. The main outcome measure was the oxygenation index on the postoperative 48h. The secondary outcome measures were the 7-day postoperative pulmonary complications and 30-day mortality rates et al.