anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: The determinants of rheumatoid arthritis (RA) severity and excess cardiovascular disease (CVD) are incompletely understood. Biomechanical factors are known to influence RA severity. Articular stiffness correlates with arterial and skin stiffness. This study explored the hypothesis that constitutional stiffness is a common determinant of RA severity and excess CVD.
METHODS: Fifty-eight patients with anti-CCP antibody (ACPA) positive RA and 57 controls were enrolled noting age, sex, body mass index, alcohol and tobacco exposure, Shared Epitope status and in RA disease duration, disease activity, ACPA titre and radiographic damage. Severe RA was defined as radiographic progression >1.3 mSharp points/year or requiring biological disease-modifying antirheumatic drugs (bDMARDs). Articular stiffness (Beighton Score and right 5th metacarpophalangeal (MCP) joint stress-strain responses), carotid-femoral pulse wave velocity and skin extensibility (percent increase distance two dots with manual traction dorsum right hand) were assessed.
RESULTS: Right 5th MCP stiffness correlated with Beighton Score and with arterial and skin stiffness. High radiographic rate was associated with greater MCP articular (t test p 0.014), arterial (p 0.044) and, in RA <5 years duration, greater skin stiffness (p 0.002) with similar trends in subjects requiring bDMARDs. In RA, arterial stiffness correlated with age (ß p<0.005), articular (ß p<0.001) and skin stiffness (ß p 0.037) and inversely with alcohol consumption (p 0.035).
CONCLUSIONS: Articular, arterial and skin stiffness correlated with each other and with RA severity. As skin is not affected by RA, this association suggests that constitutional stiffness might be a common determinant of RA and CVD. Prospective studies of at-risk preclinical and early RA are required to determine if this relationship is causal.
TRIALS REGISTRATION NUMBER: ACTRN12617000170325.
BACKGROUND: To identify the risk factors and construct a predictive model for early recurrence of hepatitis B virus(HBV-)- related hepatocellular carcinomas(HCCs) after radical resection.
DATA AND METHODS: A total of 465 HBV-related HCC patients underwent radical resections between January 1, 2012 and August 31, 2018.Their data were collected through the inpatient information management system of the First Affiliated Hospital of University of Science and Technology of China. Survival and subgroup analyses of early recurrence among male and female patients were performed using Kaplan-Meier curves. The independent risk factors associated with early postoperative tumor recurrence were analyzed using multivariate Cox proportional hazards regression model. Based on these independent risk factors, a risk function model for early recurrence was fitted, and a column chart for the prediction model was drawn for internal and external validation.
RESULTS: A total of 181 patients developed early recurrences, including 156 males and 25 females. There was no difference in the early recurrence rates between males and females. Tumor diameters>5cm, microvascular invasion and albumin level<35 g/L were independent risk factors for early recurrence. A nomogram for the early recurrence prediction model was drawn; the areas under the curve for the model and for external verification were 0.638 and 0.655, respectively.
CONCLUSION: Tumor diameter>5 cm, microvascular invasion, and albumin level<35 g/L were independent risk factors for early recurrence. The prediction model based on three clinical indicators could predict early recurrence, with good discrimination, calibration, and extrapolation.
BACKGROUND: Inflammatory response is closely associated with secondary brain injury and pneumonia in intracerebral hemorrhage (ICH). In this study, we aimed to investigate the value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immunoinflammatory index (SII) in the development of pneumonia in ICH patients 30 days after surgery.
METHODS: We retrospectively collected clinical data on patients with ICH who underwent surgical treatment at our institution from January 2016 to December 2022, mainly including NLR, PLR, and SII at different time points. Receiver operating characteristic curves were used to compare the value of different inflammatory indicators in predicting the development of postoperative pneumonia 30 days after surgery in ICH patients, and multivariate logistic regression analyses were used to identify independent risk factors for pneumonia 30 days after surgery.
RESULTS: Among 112 patients with ICH undergoing surgical treatment, 31 (27.7%) developed pneumonia postoperatively. The results of the univariate analysis demonstrated that patients in the pneumonia group experienced significantly higher blood glucose, NLR at 72 hours postoperatively, PLR at 72 hours postoperatively, and SII at 72 hours postoperatively (SII3) than those in the nonpneumonia group, and significantly lower admission Glasgow Coma Scale scores than those in the nonpneumonia group (all P < 0.05). NLR, PLR, and SII showed increasing and then decreasing in the disease process of ICH and peaked at 48 hours postoperatively. Multivariable logistic regression analysis revealed that SII3 was an independent risk factor for postoperative pneumonia 30 days after surgery in ICH patients (odds ratio = 1.001, 95% confidence interval: 1.000-1.002, P = 0.008). The area under the curve of the developed nomogram model was 0.895 (95% confidence interval = 0.823-0.967), with a sensitivity and specificity of 0.903 and 0.815, respectively, providing good predictive power.
CONCLUSIONS: In the course of ICH, NLR, PLR, and SII increased and then decreased and peaked at 48 hours postoperatively. The SII3 was the best predictor of the occurrence of pneumonia postoperatively in ICH patients.
Patients receive copanlisib IV over 60 minutes on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo CT or MRI during screening and on study, as well as during follow-up as clinically necessary. Patients undergo biopsies and blood sample collection on study.
The invention discloses a porous polymer nanoparticle and a preparation method thereof. The method is characterized by adding 10-200 parts of polymers, 0-200 parts of additives and 300-1000 parts of solvents by weight into a dissolution kettle with a stirrer and a thermometer, stirring to dissolve the mixture at 30-100 DEG C and obtaining polymer solution through defoaming and aging; and placing the polymer solution into an electrostatic field under 5-25KV to prepare the porous nanoparticle through electrostatic spraying. Smooth split of the nanoparticle is realized by a frozen breaking method, thus achieving the aims of minute observation, research and control of the inside structure of the nanoparticle. Electron microscope scanning test result shows that the diameter of the nanoparticleis distributed from hundreds of nanometers to thousands of nanometers, and the nanoparticle matrices are all of porous structure. The porous nanoparticles in the shapes of balls, red blood cells and round lanterns can be prepared by changing the technological conditions. The nanoparticle has the advantages of small diameter, large specific surface area and controllable surface and inside structure and is used in such fields as drug release, catalyst carriers, chemical sensors, biomolecule analysis, gas chromatography, ion exchange and polymerization carriers.
PURPOSE:The diseased part is cured with zone by using a plaster having a container to be attached to the diseased part, wherein liquid ozone is injected from a bomb to the container, and a controlled amount of the ozone evaporated by the temperature difference is transferred through pores to the skin and absorbed in the diseased part. CONSTITUTION:For example, the liquid ozone 3 is filled in the bomb 1 for lighter fuel to make comvenient to carry with. The outlet port 2 of the bomb 1 is made to contact with the inlet port 4 opened at a part of the top of the ozone container to be applied to the diseased part. The liquid ozone 3 is transferred to and filled in a flexible bag made of polyethylene to enable the evaporation of the ozone by temperature difference. The part 6 of the container to be attached to the diseased part is furnished with several small pores 7 to enable the absorption of the evaporated ozone directly through the skin. The container is applied to the diseased part, and the circumference of the container is sealed with an adhesive tape 8 to prevent the escape of the ozone. The characteristic features of the invention is the use of liquid ozone in a handy form, and the easy control of the amount of ozone transferred to the skin.
As the world is becoming more corporate, the increase in number of hours a person spends in his or her workplace has certainly shifted people towards a sedentary way of life. Sitting and working for a long time in an improper position leads to the tightness and weakness of the muscles, which can lead to musculoskeletal disorders such as neck, shoulders, and lower back pains as well as anatomical disorders such as lordosis, kyphosis, and scoliosis.Most causes of these symptoms include long sitting and excessive leaning. Individuals with areas of muscular weaknesses cannot perform fundamental movement patterns due to compensatory adaptations which can increase the risk of injury. To combat workplace-caused mental and physical exhaustion physical activity has been proven to be an efficient tactic. Physical activity is known not to only treat but prevent the occurrence of a fore coming disease. Being physically active will lead to reduced stress levels and increased productivity. According to World Health Organization facts physical activity refers to all movement including during leisure time, for transport to get to and from places, or as part of a person's work. Both moderate- and vigorous-intensity physical activity improve health that also includes walking for 150-300 minutes a week for adults. Some physical activity is better than doing none. By becoming more active throughout the day in relatively simple ways, people can easily achieve the recommended activity levels.Physical Fitness is defined as the ability to perform physical activity and comprises of components such as flexibility, strength and endurance. A complete physical fitness regimen must target core and extremities. A strong musculoskeletal system is recognized as important component of health related physical fitness. Strength training program provides an opportunity to improve health, physical fitness and quality of life. Core strengthening involving multiplane movements has plausible benefits to improve functional movement patterns. Combination of core strengthening along with upper and lower extremities strengthening program is needed to improve the physical fitness in active individuals to improve their functional status. The topic of FMS (Functional Movement Status) development has received considerable interest owing to the close association between health and well-being, physical activity, and to a lesser degree physical performance.
Participants in this arm will receive dental implants and single crowns made from zirconia. The effects of zirconia on peri-implant soft tissue will be analyzed by measuring the levels of inflammatory markers and observing clinical outcomes such as bleeding on probing and pocket depth at 3 and 6 months post-implantation.
A cosmetic composition for keratin fibers results from the mixture of: an alkali-containing composition including at least one alkaline agent and at least one surfactant; and an oxidizing composition including at least one oxidizing agent, at least one fatty material. The amount of the fatty material in the alkali-containing composition is 10-50 wt%, preferably 20-40 wt%, relative to the total weight amount of the oxidizing composition. The cosmetic composition for keratin fibers includes at least one polyol in a weight amount of 0.1-40 wt%, preferably 0.5-30 wt%, relative to the total weight amount of the cosmetic composition for keratin fibers. The cosmetic composition for keratin fibers includes at least one surfactant in a weight amount of 15-30 wt% relative to the total weight amount of the cosmetic composition for keratin fibers. The cosmetic composition for keratin fibers includes at least one fatty material in a weight amount of 5-30 wt% relative to the total weight amount of the cosmetic composition for keratin fibers. The weight ratio of the surfactant to the fatty material in the cosmetic composition for keratin fibers is from 0.3 to 2.0, preferably from 0.7 to 1.3.
Despite the remarkable improvements in survival with durable continuous flow (CF) pumps and the clear lifesaving effects of Impella and veno-arterial extracorporeal membrane oxygenation (VA ECMO), serious adverse hematological events such as bleeding and thrombosis create substantial morbidity and mortality and remain major barriers for further expansion of this technology. In particular, thrombosis is a devastating adverse event during CF pump support as it can lead to stroke, device stoppage, and hemodynamic collapse. Although the annual incidence of pump thrombosis has been reported to range from 8 to nearly 30%, the pathobiological mechanisms of thrombus formation during CF pump support with ongoing anticoagulation remain elusive. Our preliminary data associates hemolysis, which is inherent to such devices due to high shear stress, with subsequent formation of thrombosis and stroke, possibly through increasing platelet activation and aggregation. Our prelim data and drawing from a body of literature from diseases of intravascular hemolysis such as sickle cell anemia suggest that free hemoglobin released during hemolysis, which reduces NO levels, may be activating platelets. In retrospective analysis, we have noted a significant reduction in mean platelet volume (potential in-vivo marker of platelet activation), thrombosis and stroke with concurrent sildenafil administration. However, this mechanism and efficacy of NO signaling enhancers such as sildenafil remains to be proven during CF pump support.

Aim: To conduct a randomized placebo controlled study to test the hypothesis that platelet activation and aggregation, endothelial dysfunction and pro-thrombotic inflammation in outpatients on chronic CF pump support can be reduced by sildenafil.
The present invention relates to a pharmaceutical composition, for preventing and treating hematological cancer, comprising a biguanide-based compound as an active ingredient. Hematological cancer is comprehensively defined as cancer occurring in a composition in the blood and is exemplified by malignant tumors in the blood, a hematopoietic organ, a lymph node, a lymphoid organ and the like. Hematological cancer has a high risk of metastasis and is difficult to treat in that cancer cells circulate in the human body via the blood. The present invention relates to a pharmaceutical composition, for preventing and treating hematological cancer, comprising a biguanide-based compound. The pharmaceutical composition additionally comprises an aldehyde inhibitor, and thus a further enhanced hematological cancer treatment effect can be expected. A pharmaceutical composition of the present invention has a notable treatment effect on various hematological cancers such as malignant lymphoma and leukemia, and thus is expected to be widely utilized for treating hematological cancer which is difficult to treat and has a poor prognosis.
Platelet-rich plasma administered as an intra-articular injection under ultrasound guidance as a series of three weekly injections to the affected knee. 3 weekly injections are of leukocyte poor, buffer/additive free, singe spin, platelet-rich plasma averaging 4mL in volume.
PURPOSE:To obtain the material having high joint strength and excellent formability, workability, durability, etc., by forming an alloy having a specific compsn. to an alloy plate of a specific thickness, applying powder and grains of a specific diameter consisting of the above-mentioned alloy on one surface thereof and then executing diffusion joining. CONSTITUTION:The alloy having the compsn. range constituting of 10 to 25wt.% Au, 15 to 35wt.% Pd, 45 to 70wt.% Ag, and further added with 0.1 to 5wt.% 1 or 2 kinds of Sn and In is made into an alloy plate 1 having 0.05 to 0.5mm thickness. The powder and grains of 0.04 to 0.8mm diameter consisting of the alloy having the above-mentioned compsn. range are applied on one surface of this alloy over the entire surface and thereafter the diffusion joining is executed. The combined material having the high joint strength is obtd. in this way and the material having the excellent characteristics as the dental material in terms of the formability, workability, durability, supporting strength, etc., is obtd.
The invention discloses a small molecular peptide PYPDW and application thereof, and belongs to the technical field of enzymolysis processing products. The amino acid sequence of the small molecule peptide PYPDW is Pro-Tyr-Pro-Asp-Trp, and is shown as SEQ ID NO. 1. Application of the small molecule peptide PYPDW in preparation of medicines for relieving Alzheimer's disease. The invention screens the small molecule peptide PYPDW from the royal jelly polypeptide by utilizing molecular docking, researches show that the small molecule peptide PYPDW has inhibitory activity on key receptor proteins Fyn and Keap 1 causing cognitive dysfunction due to oxidative stress, has the effect of inhibiting acetylcholinesterase, has the effect of enhancing the activity of superoxide dismutase, and can up-regulate egr 1 genes and down-regulate caspase 3 gene expression. Thus, the small molecule peptide PYPDW has potential as a drug for alleviating alzheimer's disease.
Concerning the perioperative outcomes of patients diagnosed with COVID-19 who underwent emergency laparotomy, more data must be collected. Because COVID-19 can affect multiple organs, cause various complications, and act as a risk factor for surgery, in this study, we aimed to compare the outcomes of emergency laparotomy between SARS-CoV-2 infected and uninfected patients. This retrospective cohort study was conducted on patients who underwent emergency laparotomy from December 2021 to December 2022. Postoperative outcomes were compared between patients with and without confirmed perioperative SARS-CoV-2 infection. The primary outcome was 30-day mortality. Secondary outcomes were postoperative intensive care unit admission, hospital length of stay, re-operation, and postoperative complications. Data were analyzed by SPSS statistic version 27. In this study, 50 patients in the COVID-19 group and 91 patients in the non-COVID-19 group were assessed. The 30-day mortality in the COVID-19 group was significantly higher than in the non-COVID-19 group (34% vs. 12.1%, respectively, P = 0.004). Postoperative complications were significantly higher in the COVID-19 group (64% vs. 26.4%, P < 0.001). The frequency of ICU admission and need for re-operation were significantly higher in the COVID-19 group (P = 0.003 and P = 0.039, respectively). Length of hospital stay was significantly lower in the non-COVID-19 group (P = 0.021). In patients with confirmed COVID-19, emergency laparotomy is associated with increased postoperative morbidity and mortality. Additionally, emergency laparotomy is associated with increasing postoperative complications, length of hospital stay, intensive care admission, and additional surgery requirement.
Polypeptides are susceptible to denaturation or enzymatic degradation in the blood, liver or kidney. Due to the low stability of some polypeptides, it has been required to administer polypeptide drugs in a sustained frequency to a subject in order to maintain an effective plasma concentration of the active substance. Furthermore, pharmaceutical compositions of therapeutic peptides preferably have a shelf- life of several years in order to be suitable for common use. However, peptide compositions are inherently unstable due to sensitivity towards chemical and physical degradation. In part, the invention provides SAP variant proteins, compositions, pharmaceutical preparations and formulations having a prolonged in vivo half-life, prolonged shelf-life, or rather increased in vitro stability, or increased manufacturing efficiency compared to human SAP. Advantages of increased plasma half-life include, but are not limited to, reducing the amount and/or frequency of dosing.
Objectives: Petrous bone cholesteatoma (PBC) is a rare condition of the petrous portion of the temporal bone. Treatment of choice consists of radical surgical removal, paying attention to protect the facial nerve and inner ear as far as possible. The aim of the present study was to evaluate the efficacy of modified translabyrinthine techniques in preserving hearing function and the use of the adjuvant endoscopic techniques in a group of PBC patients. Methods: This study comprised 16 cases of PBCs surgically treated in our Department. Pre- and post-operative hearing status was assessed with pure tone audiometry and speech discrimination and graded according to the Gardner- Robertson classification system. Facial function was based on the House Brackman (HB) classification. PBCs were grouped using Sanna's classification. The choice of surgical technique was based on the above findings together with preoperative evidence. Post-operative follow-up ranged from 1 to 10 years and also included Computed Tomography and Magnetic Resonance Imaging assessment. Results: PBCs were classified as follows: 37.5% infralabyrinthine; 43.75% supralabyrinthine; and 18.75% massive. Preservation of the bone conduction threshold was feasible in 62.5% of patients. For supralabyrinthine PBCs a subtotal petrosetomy was performed in all cases and hearing preservation was possible in 57% of them: an adjuvant endoscopic approach was performed in 43%. Infralabyrinthine PBCs were treated using a modified translabyrinthine approach with preservation of bone conduction in 83% of patients; an adjuvant endoscopic approach was performed in 50% cases. One patient with a massive cholesteatoma was treated by modified translabyrinthine approach, preserving a serviceable level of hearing. In all massive cases, an adjuvant endoscopic approach was performed. In 2 patients with preoperative palsy, facial nerve function showed an improvement. The follow-up period revealed evidence of limited recurrence at CT imaging in 2 patients. Conclusions: The introduction of modified surgical approaches, able to preserve the anatomical-functional structures, have shown an improvement of post-operative hearing outcomes.