anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Little Flower Yoga for Kids is a New York based organization dedicated to making the tools of yoga and mindfulness available to all children and teens. Their Teacher Training Program focuses on the physical, mental emotional, and social wellbeing of students. Teachers are trained to use the five elements format (connect, breathe, move, focus, relax). Implementation of the Little Flower Yoga for Kids curriculum will be manualized prior to the start of the study with Ms. Love, and will be presented as a series of activities (e.g., poses) throughout the school year. The emphasis in these yoga and mindfulness activities is exploration not competition, which allows the child to learn and develop at her own pace with the support of Ms. Love. The children participate in the Little Flower Yoga for Kids intervention at school for 40 minutes per class, 3 to 5 times per week, for the entire academic school year (9 months).
An absorber intercooler having a heat exchanger formed integrally therein. The absorber intercooler includes a cylindrical outer casing having a tube bundle disposed longitudinally therein. Inlet and outlet ports are provided in the cylindrical casing to allow for the flow of refrigerant around the tube bundle. Upper and lower end plates, having a plurality of openings therein, seal the upper and lower ends of the bundle. A liquid inlet pipe provides a flow of liquid absorbent through the upper end plate into the tube bundle. A vapor inlet pipe provides a flow of vapor into the bottom of the intercooler, and the vapor flows through a central opening in the lower end plate into a centrally disposed vapor flow pipe. The vapor flows upwardly therein through the upper end plate. A cap is provided on the upper end of the vapor flow pipe to prevent liquid absorbent from flowing down into the pipe, and also provides for an even radial distribution of the vapors at the cap. A distributor pan is positioned below the aforementioned cap, and provides for an even distribution of the resultant liquid into the tube bundle.
Medium chain triglycerides 2 capsules twice daily for six months. Endoscopy and biopsies taken as described under intervention.
A method and system for the relief from side effects of cannabis consumption, the method comprising storing a profile of a user, monitoring the user after consumption of a cannabis product via wearable biometric sensors, identifying one or more physical effects, and recommending at least one remedy corresponding to the physical effects from a database of remedies. The remedy may contain one or more cannabis products and may form part of a remedy kit containing a plurality of remedies and an application device such as a vaporizer. The recommendation may be based on user input e.g. to a questionnaire, game or puzzle. The recommendation may be generated based on a comparison of the physical effects to a predefined baseline wherein the baseline may be specific to an individual user. The remedy database may be updated with new remedies. The profile of the user may be updated based on the identified physical effects and the recommended remedy. The user may continue to be monitored after administration of the first remedy and a next remedy recommended if the physical effects continue to be identified.
Spinally Evoked Motor Potentials (sEMP) will be obtained while stimulating the spinal cord at a single site with single pulses. sEMP are the electromyograph responses of the peripheral muscles to electrical stimulation of the spinal cord. We will test various waveform combinations of biphasic and monophasic waveforms with modulation frequencies of 0-10 kHz. Participants will also ambulate while receiving continuous stimulation of the various waveform combinations to determine what stimulation intensity is comfortable for each combination. The order we complete this testing will be randomized. All participants will perform testing in a different order.
INTRODUCTION: During an innate inflammation, immune cells form distinct pro- and anti-inflammatory regions around pathogen-containing core-regions. Mast cells are localized in an anti-inflammatory microenvironment during the resolution of an innate inflammation, suggesting antiinflammatory roles of these cells.
METHODS: High-content imaging was used to investigated mast cell-dependent changes in the regional distribution of immune cells during an inflammation, induced by the toll-like receptor (TLR)-2 agonist zymosan.
RESULTS: The distance between the zymosan-containing core-region and the anti-inflammatory region, described by M2-like macrophages, increased in mast cell-deficient mice. Absence of mast cells abolished dendritic cell (DC) activation, as determined by CD86-expression and localized the DCs in greater distance to zymosan particles. The CD86- DCs had a higher expression of the pro-inflammatory interleukins (IL)-1β and IL-12/23p40 as compared to activated CD86+ DCs. IL-4 administration restored CD86 expression, cytokine expression profile and localization of the DCs in mast cell-deficient mice. The IL-4 effects were mast cell-specific, since IL-4 reduction by eosinophil depletion did not affect activation of DCs.
DISCUSSION: We found that mast cells induce DC activation selectively at the site of inflammation and thereby determine their localization within the inflammation. Overall, mast cells have antiinflammatory functions in this inflammation model and limit the size of the pro-inflammatory region surrounding the zymosan-containing core region.
This narrative review discusses treatment strategies and key considerations guiding decisions in the surgical management of fracture-related infections (FRI). Treatment options primarily revolve around two approaches: debridement antibiotics and implant retention (DAIR), or implant exchange, either in a one or multiple-stage strategy. Several considerations, including time since infection onset, implant type, stability, causative pathogens, host physiology, and soft tissue conditions, inform the choice of surgical intervention for FRI. Current literature supports the preference for a DAIR approach in cases with a short duration of ongoing symptoms, a stable implant with satisfactory fracture reduction, and a viable soft tissue envelope. Conversely, one- or multiple-stage implant exchange is deemed beneficial in instances of compromised local and systemic host physiology, mature biofilm, difficult-to-treat pathogens, intramedullary implants, and cases involving reinfections or failed DAIR procedures. Notably, these recommendations draw parallels from periprosthetic joint infection treatment strategies, constrained by the limited availability of randomized controlled trials comparing these options specifically in acute FRI. In conclusion, future perspectives call for extensive investigations into biofilm maturation and the impact of time on treatment outcomes. Additionally, there is a need for a standardized classification system for FRI to enhance the comparability of treatment outcomes in FRI management.
Cardiac fibrosis (c-fibrosis) is a critical factor in cardiovascular diseases, leading to impaired cardiac function and heart failure. This study aims to optimize the isoproterenol (ISO)-induced c-fibrosis model and evaluate the therapeutic efficacy of dendrosomal nano-curcumin (DNC) in both in-vitro and in-vivo conditions. Also, we were looking for the differentially expressed genes following the c-fibrosis induction. At the in-vitro condition, primary cardiac fibroblasts were exclusively cultured on collagen-coated or polystyrene plates and, were treated with ISO for fibrosis induction and post-treated or co-treated with DNC. RT-qPCR and flow cytometry analysis indicated that DNC treatment attenuated the fibrotic effect of ISO treatment in these cells. At the in-vivo condition, our findings demonstrated that ISO treatment effectively induces cardiac (and pulmonary) fibrosis, characterized by pro-fibrotic and pro-inflammatory gene expression and IHC (α-SMA, COL1A1, and TGFβ). Interestingly, fibrosis symptoms were reduced following the pretreatment, co-treatment, or post-treatment of DNC with ISO. Additionally, the intensive RNAseq analysis suggested the COMP gene is differentially expressed following the c-fibrosis and our RT-qPCR analysis suggested it as a novel potential marker. Overall, our results promise the application of DNC as a potential preventive or therapy agent before and after heart challenges that lead to c-fibrosis.
Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poorly understood. Here, we employ a multi-modal single cell transcriptome analysis to dissect this process. In the internodular compartment, we identify proliferating cerebellar granular neuronal precursor-like malignant cells, along with stromal, vascular, and immune cells. In contrast, the nodular compartment comprises postmitotic, neuronally differentiated malignant cells. Both compartments are connected through an intermediate cell stage resembling actively migrating CGNPs. Notably, we also discover astrocytic-like malignant cells, found in proximity to migrating and differentiated cells at the transition zone between the two compartments. Our study sheds light on the spatial tissue organization and its link to the developmental trajectory, resulting in a more benign tumor phenotype. This integrative approach holds promise to explore intercompartmental interactions in other cancers with varying histology.
PURPOSE: This study used a semiautomated fine-grained temporal analysis to extract features of temporal oral diadochokinetic (DDK) performance across multiple modalities and tasks, from neurologically healthy and impaired individuals secondary to amyotrophic lateral sclerosis (ALS). The aims were to (a) delineate temporal oral DDK deficits relating to the neuromotor pathology of ALS and (b) identify the optimal task-feature combinations to detect speech impairment in ALS.
METHOD: Mandibular myoelectric, kinematic, and acoustic data were acquired from 13 individuals with ALS and 10 healthy controls producing three alternating motion rate tasks and one sequential motion rate task. Twenty-seven features were extracted from the multimodal data, characterizing three temporal constructs: duration/rate, variability, and coordination. The disease impacts on these features were assessed across tasks, and the task eliciting the greatest disease-related change was identified for each feature. Such "optimal" task-feature combinations were fed into logistic regression to differentiate individuals with ALS from healthy controls.
RESULTS: Temporal deficits in ALS were characterized by (a) increased duration and variability and reduced coordination of jaw muscle activities, (b) increased duration and variability and altered temporal symmetry of jaw velocity profile, (c) increased muscle-burst-to-peak-velocity duration, and (d) increased motion-to-voice onset duration. These temporal features were differentially affected across tasks. The optimal task-feature combinations, which were further clustered into three composite factors reflecting temporal variability, coarser-grained duration, and finer-grained duration, differentiated ALS from controls with an F1 score of 0.86 (precision = 1.00, recall = 0.75).
CONCLUSIONS: Temporal oral DDK deficits are likely attributed to a hierarchy of interrelated neurophysiological and biomechanical factors associated with the neuromotor pathology of ALS. These deficits, as assessed crossmodally, provide previously unavailable insights into the multifaceted timing impairment of oromotor performance in ALS. The optimal task-feature combinations targeting these deficits show promise as quantitative markers for (early) detection of speech impairment in ALS.
Participants will receive an assigned dose of AC699 monotherapy during dose escalation. One cycle is defined as 28 days.
BACKGROUND: Frailty is a dynamic syndrome characterized by reduced physiological reserve to maintain homeostasis. Prospective studies have reported frailty worsening in women with breast cancer during chemotherapy, with improvements following treatment. We evaluated whether the Faurot frailty index, a validated claims-based frailty measure, could identify changes in frailty during chemotherapy treatment and identified predictors of trajectory patterns.
METHODS: We included women (65+ years) with stage I-III breast cancer undergoing adjuvant chemotherapy in the SEER-Medicare database (2003-2019). We estimated the Faurot frailty index (range: 0-1; higher scores indicate greater frailty) at chemotherapy initiation, 4 months postinitiation, and 10 months postinitiation. Changes in frailty were compared to a matched noncancer comparator cohort. We identified patterns of frailty trajectories during the year following chemotherapy initiation using K-means clustering.
RESULTS: Twenty-one thousand five hundred and ninety-nine women initiated adjuvant chemotherapy. Mean claims-based frailty increased from 0.037 at initiation to 0.055 4 months postchemotherapy initiation and fell to 0.049 10 months postinitiation. Noncancer comparators experienced a small increase in claims-based frailty over time (0.055-0.062). We identified 6 trajectory patterns: a robust group (78%), 2 resilient groups (16%), and 3 nonresilient groups (6%). Black women and women with claims for home hospital beds, wheelchairs, and Parkinson's disease were more likely to experience nonresilient trajectories.
CONCLUSIONS: We observed changes in a claims-based frailty index during chemotherapy that are consistent with prior studies using clinical measures of frailty and identified predictors of nonresilient frailty trajectories. Our study demonstrates the feasibility of using claims-based frailty indices to assess changes in frailty during cancer treatment.
The invention discloses curcumin dicaprate and a derivative nano suspension agent, a preparation method of freeze-dried powder thereof and an application in the treatment of depression and tumor. A surfactant serves as a main pharmaceutical adjunct, particularly poloxamer, and curcumin dicaprate nano granulation is successfully realized by employing the wet grinding combined freeze drying technology. The curcumin dicaprate is prepared into a pharmaceutically acceptable oil diluent, and the reconstructed curcumin dicaprate and derivative nano suspension agent can be prepared into a nano suspension agent for injection with the particle size of about 500nm. The nano suspension agent consists of the following components: curcumin dicaprate and/or derivatives thereof and the surfactant. The nano suspension agent preparation can be applied to treating depression and tumors. The nano suspension agent preparation is simple in composition, high in stability, high in needle penetration, economic and reliable in preparation method and easy to industrialize.
Background: Surgical site complications (SSCs) are common, yet preventable hospital-acquired conditions. Single-use negative pressure wound therapy (sNPWT) has been shown to be effective in reducing rates of these complications. In the era of value-based care, strategic allocation of sNPWT is needed to optimize both clinical and financial outcomes. Materials and Methods: We conducted a retrospective analysis using data from the Premier Healthcare Database (2017-2021) for 10 representative open procedures in orthopedic, abdominal, cardiovascular, cesarean delivery, and breast surgery. After separating data into training and validation sets, various machine learning algorithms were used to develop pre-operative SSC risk prediction models. Model performance was assessed using standard metrics and predictors of SSCs were identified through feature importance evaluation. Highest-performing models were used to simulate the cost-effectiveness of sNPWT at both the patient and population level. Results: The prediction models demonstrated good performance, with an average area under the curve of 76%. Prominent predictors across subspecialities included age, obesity, and the level of procedure urgency. Prediction models enabled a simulation analysis to assess the population-level cost-effectiveness of sNPWT, incorporating patient and surgery-specific factors, along with the established efficacy of sNPWT for each surgical procedure. The simulation models uncovered significant variability in sNPWT's cost-effectiveness across different procedural categories. Conclusions: This study demonstrates that machine learning models can effectively predict a patient's risk of SSC and guide strategic utilization of sNPWT. This data-driven approach allows for optimization of clinical and financial outcomes by strategically allocating sNPWT based on personalized risk assessments.
An edible vitamin A preparation in powder form is prepared by macerating animal livers, extracting the water soluble constituents by mixing the macerated livers with warm water at about 60 DEG  C. for about 20-30 minutes in the presence of lactic acid, separating the fluid from the water insoluble portion and drying the residue of water insoluble constituents in vacuo at low temperature.  The lactic acid in the extracting fluid is present in amounts from 1 per cent to 0.1 per cent by weight of the mixture.  The dried residue serves as a carrier for fish liver oil.  The fish oil is added in amounts up to one part of fish oil to 15 parts of dried liver residue.  It is preferred that the drying of the liver residue should take place in vacuo in a gaseous atmosphere such as nitrogen or carbon dioxide at a temperature of the order of 100 DEG  to 110 DEG  F., and when dry a small amount of tribasic calcium phosphate is added to keep it dry. It is stated that in the product the stability of the vitamin A potency is very high, the natural anti-oxidants of the liver are substantially intact and the enzymic activity is practically nil. Examples are given of the detailed procedure necessary to carry the invention into effect.ALSO:An edible vitamin A preparation in powder form is prepared by macerating animal livers, extracting the water-soluble constituents by mixing the macerated liver with warm water at about 60 DEG  C. for about 20-30 minutes in the presence of lactic acid, separating the fluid from the water-insoluble portion and drying the residue of water-insoluble constituents in vacuo at low temperature.  The lactic acid in the extracting fluid is present in amounts from 0.1 per cent to 1 per cent by weight of the mixture. The dried residue serves as a carrier for fish oil.  The fish oil is added in amounts up to one part of fish oil to 15 parts of dried liver residue.  It is preferred that the drying of the liver residue should take place in vacuo in a gaseous atmosphere such as nitrogen or carbon dioxide at a temperature of the order of 100 DEG  to 110 DEG  F., and when dry a small amount of tribasic calcium phosphate is added to keep it dry.  It is stated that in the product the stability of the vitamin A potency is very high, the natural anti-oxidants of the liver are substantially intact and the enzymic activity is practically nil.  Examples are given of the detailed procedure necessary to carry the invention into effect.
Placebo for montelukast 5-7 days 2 tablets bid. Efficacy of treatment is evaluated on airway responsiveness to inhaled leukotriene E4.
The invention relates to the technical field of biology, in particular to application of a CDK7 inhibitor THZ1 in radiotherapy resistant treatment of nasopharyngeal carcinoma. The invention firstly explores the difference of the phosphorylation levels of the RNA polymerase II C-terminal repetitive domain S5 in nasopharyngeal carcinoma radiotheraphy resistant and radiotheraphy sensitive cells and after the radiotheraphy irradiation. The inhibitor THZ1 of CDK7 target is adopted to detect the drug sensitivity of nasopharyngeal carcinoma radiotherapy resistant and sensitive cells. THZ1 and radiotherapy are combined to act on radiotherapy resistant cells, and whether THZ1 can increase the sensitivity of radiotherapy is researched. THZ1 is applied to a radiotherapy resistant mouse model, and the treatment effect of THZ1 on radiotherapy resistant tumors is explored. The CDK7 inhibitor THZ1 can effectively inhibit the growth of nasopharyngeal carcinoma radiotherapy resistant tumors in-vitro cell experiments and in-vivo nude mouse subcutaneous tumor experiments. From cellular and animal levels, THZ1 was shown to increase sensitivity to radiation therapy when used in combination with radiation therapy, indicating that THZ1 is feasible for the treatment of nasopharyngeal carcinoma against radiation therapy.
Background: This study evaluated the associations between inattention, impulsivity, and attention deficit hyperactivity disorder (ADHD) in women with premenstrual dysphoric disorder (PMDD) across the menstrual cycle. Methods: This study enrolled 58 women with PMDD and 50 controls. Symptoms were assessed using the Attention and Performance Self-Assessment Scale and the Dickman Impulsivity Inventory during the pre-ovulatory (PO), mid-luteal (ML), and late luteal (LL) phases of the menstrual cycle. Results: The chi-square analysis revealed a significant association between ADHD and PMDD. Women with PMDD experienced a greater increase in scores of prospective everyday memory problems and difficulties maintaining focused attention from the PO phase to LL phase than the controls; in addition, they had higher scores in dysfunctional impulsivity during the LL phase than the controls. Among women in the PMDD group, those with ADHD had higher scores in prospective everyday memory problems and dysfunctional impulsivity during the PO and ML phases than those without ADHD. Women in the PMDD group without ADHD had a greater increase in scores of prospective everyday memory problems, difficulties maintaining focused attention, and dysfunctional impulsivity from the PO phase to the LL phase than the controls. Conclusion: Our study demonstrated that women with PMDD were more likely to have comorbid ADHD and higher levels of inattention across the menstrual cycle. PMDD was associated with increased impulsivity during the LL phase, independent of ADHD, but it was not associated with a persistent elevation of impulsivity. Furthermore, PMDD women with comorbid ADHD experienced higher inattention and impulsivity during the PO and ML phases than those without it. Thus, ADHD comorbidity should be assessed when assessing or intervening in the symptoms of inattention and impulsivity in women with PMDD.
The purpose of this screening program is to identify people at high risk for developing celiac disease, which is due to the genetic intolerance of gluten - a protein found in wheat, rye and barley. When a person with celiac disease consumes gluten-containing foods, his immune system damages the mucous membrane of the small intestine. Inflammation develops and, as a result, the absorption of vitamins, minerals and other vital nutrients is disrupted. Studies have shown that timely diagnosis of celiac disease is important for the treatment or prevention of its complications. Left untreated, the disease can lead to impaired growth and development, diabetes, cancer, or other diseases. In Europe and the USA, celiac disease is a chronic disease that occurs in approximately one in 100 and one in 22 who have risk factors. There are frequent cases of an erased or low-symptom course of celiac disease. Unfortunately, ninety-seven percent of cases remain undiagnosed and, accordingly, do not receive proper treatment. A screening program will increase knowledge about the disease and contribute to the early detection of the disease.