anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Traditional Chinese exercises (Taichi, Wuqinxi, Liuzijue, and Baduanjin) are considered effective alternative treatments for improving symptoms in the stable phase of COPD. However, the most effective exercise remains unknown. This study compared the effectiveness of different traditional Chinese exercises on pulmonary function in patients with stable chronic obstructive pulmonary disease (COPD) using a network meta-analysis.
METHODS: From database establishment until September 2023, eligible randomized controlled trials (RCTs) were searched. Two reviewers performed the risk of bias assessment of the included studies using the Cochrane Collaboration tool, and the evidence level was suggested using the GRADE system.
RESULTS: Fifty-seven studies comprising 4294 patients were included. The results of the network meta-analysis show that Baduanjin was most effective in improving the forced expiratory volume in the first second (FEV1). However, Liuzijue significantly improved the first-second forced vital capacity percentage of expected value (FEV1%) and the ratio of the forced expiratory volume in the first second to the forced vital capacity (FEV1/FVC). The probability ranking results indicated that Liuzijue was the most effective, followed by Baduanjin, Wuqinxi, and Taichi. Subgroup analysis in conjunction with intervention duration revealed that Liuzijue had a significant advantage over other interventions for improving FEV1, FEV1%, and FEV1/FVC within 6 months and improved FEV1% and FEV1/FVC for ≥ 6 months. Moreover, Subgroup analysis based on baseline pulmonary function revealed that Liuzijue had a significant advantage over other interventions for improving FEV1% within severe and moderate groups. Finally, Subgroup analysis based on the frequency of interventions showed that Liuzijue was still more effective in improving FEV1, FEV1%, and FEV1/FVC in the ≥ three times one week.
CONCLUSION: Liuzijue was more effective than Taichi, Wuqinxi, Liuzijue, and Baduanjin in improving pulmonary function in patients with stable COPD.
Unlike classical protein kinase A, with separate catalytic and regulatory subunits, EPACs are single chain multi-domain proteins containing both catalytic and regulatory elements. The importance of cAMP-Epac-signaling as an energy provider has emerged over the last years. However, little is known about Epac1 signaling in chronic kidney disease. Here, we examined the role of Epac1 during the progression of glomerulonephritis (GN). We first observed that total genetic deletion of Epac1 in mice accelerated the progression of nephrotoxic serum (NTS)-induced GN. Next, mice with podocyte-specific conditional deletion of Epac1 were generated and showed that NTS-induced GN was exacerbated in these mice. Gene expression analysis in glomeruli at the early and late phases of GN showed that deletion of Epac1 in podocytes was associated with major alterations in mitochondrial and metabolic processes and significant dysregulation of the glycolysis pathway. In vitro, Epac1 activation in a human podocyte cell line increased mitochondrial function to cope with the extra energy demand under conditions of stress. Furthermore, Epac1-induced glycolysis and lactate production improved podocyte viability. To verify the in vivo therapeutic potential of Epac1 activation, the Epac1 selective cAMP mimetic 8-pCPT was administered in wild type mice after induction of GN. 8-pCPT alleviated the progression of GN by improving kidney function with decreased structural injury with decreased crescent formation and kidney inflammation. Importantly, 8-pCPT had no beneficial effect in mice with Epac1 deletion in podocytes. Thus, our data suggest that Epac1 activation is an essential protective mechanism in GN by reprogramming podocyte metabolism. Hence, targeting Epac1 activation could represent a potential therapeutic approach.
Tyramine Challenge Test

Results of a tyramine challenge study indicate that rasagiline at recommended doses is relatively selective for inhibiting MAO-B and can be used without dietary tyramine restriction. However, certain foods (e.g., aged cheeses, such as Stilton cheese) may contain very high amounts of tyramine (i.e., 150 mg or greater) and could potentially cause severe hypertension caused by tyramine interaction in patients taking rasagiline due to mild increased sensitivity to tyramine at recommended doses. Relative selectivity of rasagiline for inhibiting MAO-B diminished in a dose-related manner as the dose progressively increased above the highest recommended daily dose (1 mg) [ see Warnings and Precautions ( 5.1) and Drug Interactions ( 7.7) ] . 

Platelet MAO Activity in Clinical Studies

Studies in healthy subjects and in Parkinson’s disease patients have shown that rasagiline inhibits platelet MAO-B irreversibly. The inhibition lasts at least 1 week after last dose. Almost 25-35% MAO-B inhibition was achieved after a single rasagiline dose of 1 mg/day and more than 55% of MAO-B inhibition was achieved after a single rasagiline dose of 2 mg/day. Over 90% inhibition was achieved 3 days after rasagiline daily dosing at 2 mg/day and this inhibition level was maintained 3 days postdose. Multiple doses of rasagiline of 0.5, 1, and 2 mg per day resulted in complete MAO-B inhibition.
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation of Mecp2 gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett syndrome (RTT) both in patients and in mouse models of this disorder and can affect synaptogenesis, glial metabolism and inflammation. Here we assessed whether treatment of adult (5-6 months old) symptomatic Mecp2-heterozygous female mice with N-acetyl cysteine conjugated to dendrimer (D-NAC), which is known to target glia and modulate inflammation and oxidative injury, results in improved behavioral phenotype, sleep and glial inflammatory profile. We show that unbiased global metabolomic analysis of the hippocampus and striatum in adult Mecp2-heterozygous mice demonstrates significant differences in lipid metabolism associated with neuroinflammation, providing the rationale for targeting glial inflammation in this model. Our results demonstrate that treatment with D-NAC (10 mg/kg NAC) once weekly is more efficacious than equivalently dosed free NAC in improving the gross neurobehavioral phenotype in symptomatic Mecp2-heterozygous female mice. We also show that D-NAC therapy is significantly better than saline in ameliorating several aspects of the abnormal phenotype including paw clench, mobility, fear memory, REM sleep and epileptiform activity burden. Systemic D-NAC significantly improves microglial proinflammatory cytokine production and is associated with improvements in several aspects of the phenotype including paw clench, mobility, fear memory, and REM sleep, and epileptiform activity burden in comparison to saline-treated Mecp2-hetereozygous mice. Systemic glial-targeted delivery of D-NAC after symptom onset in an older clinically relevant Rett syndrome model shows promise in improving neurobehavioral impairments along with sleep pattern and epileptiform activity burden. These findings argue for the translational value of this approach for treatment of patients with Rett Syndrome.
The initial means of detecting right ventricular (RV) dilatation is often transthoracic echocardiography (TTE), and once the presence of RV dilatation is suspected, there is the possibility of RV volume overload, RV pressure overload, RV myocardial disease, and even nonpathological RV dilatation. With respect to congenital heart disease with RV volume overload, defects or valvular abnormalities can be easily detected with TTE, with the exception of some diseases. Volumetric assessment using three-dimensional echocardiography may be useful in determining the intervention timing in these diseases. When the disease progresses in patients with pulmonary hypertension as a result of RV pressure overload, RV dilatation becomes more prominent than hypertrophy, and RV functional parameters predict the prognosis at this stage of maladaptive remodeling. The differential diagnosis of cardiomyopathy or comparison with nonpathological RV dilatation may be difficult in the setting of RV myocardial disease. The characteristics of RV functional parameters such as two-dimensional speckle tracking may help differentiate RV cardiomyopathy from other conditions. We review the diseases presenting with RV dilatation, their characteristics, and echocardiographic findings and parameters that are significant in assessing their status or intervention timing.
14,471. Szendeffy, A. de. June 19. Iod- and brom-terpene derivatives are prepared by combining terpenes or allied bodies with iodine or bromine or their compounds. According to one example, menthol is dissolved in olive oil and layered over with a solution of iodine in potassium iodide. The fat solution takes up the iodine. In other examples, iodine and terpin hydrate are rubbed up together; or a mixture of iodoform and menthol is sublimed
Patients will be provided a prescription for low dose opioids for 5 days postoperatively (Hydrocodone/Acetaminophen 5/325mg or Oxycodone/Acetaminophen 5/325mg) to be taken every 6 hours as needed for pain. Refills may be provided (Hydrocodone/Acetaminophen 5/325mg or Oxycodone/Acetaminophen 5/325mg) if requested by the patient at the providers discretion. In addition, patients will also be prescribed Gabapentin 300mg q8 hours or Pregabalin 75mg twice daily and a muscle relaxer (Methocarbamol 750mg BID or Flexeril 5-10 mg TID) as needed for spasms. Alternative muscle relaxers (Metaxalone 800 mg TID or Tizanidine 2-6 mg TID) may be utilized if contraindications to methocarbamol and cyclobenzaprine exist.
The invention relates to a discovery of a novel effective ingredient in a sporocarp of Cordyceps militaris (Yue96-18) bacterial classification, a structural identification of the effective ingredient, a confirmation of a structural formula and an application. The invention belongs to the biology field. The compound is obtained by extracting and purifying the Cordyceps militaris sporocarp. The Cordyceps militaris Ascomycotina, Pyrenomycetes, Sphaerinles, Claviticpitaceae and Cordyceps sp. are type species of Cordyceps. The Cordyceps militaris sporocarp through artificial cultivation employs a chromatogram and wave spectrum technology and a chemical method for chemical composition research from Cordyceps militaris(L.) Link, The invention confirms that the Cordyceps militaris sporocarp through artificial cultivation contains unique effective component and main effect, and provides a base for research of the drug effect.
PURPOSE:To obtain an impression material having improved moisture resistance and insensitive to moisture in atmosphere, by adding an additive such as a hydrocarbon having specific carbon number, a silane coupling agent, etc. to an impression material composed mainly of an alginic acid salt. CONSTITUTION:(A) An algenic acid salt is compounded with (B) a curing agent consisting of calcium sulfate and/or lead silicate, (C) a filler such as diatomaceous earth, talc, silica, etc., and (D) an additive selected from (i) a >=8C hydrocarbon, (ii) a silane coupling agent, (iii) a titanate coupling agent and (iv) a hydrophobic polymer having a contact angle of >=45 deg., preferably >=80 deg. (e.g., PE, PP, PVC, nylon, etc.). The amount of the additive is preferably 0.01-5.0wt%, especially 0.05-1.0wt% based on the impression material. The effect is especially remarkable when a phosphoric acid salt or an oxalic acid salt is added to the composition for the control of the gelation time within a proper range (e.g. 1- 5min) to improve the workability.
Compositions, including albumin compositions, which inhibit or reduce epithelial- mesenchymal transition (EMT) are described. In embodiments, such compositions comprise albumin and either i) no pro-EMT agent or a low concentration of pro-EMT agent; ii) a content of pro-EMT agent and anti-EMT agent in a ratio of pro-EMT agent : anti-EMT agent that is from 7:3 to 0:10; or iii) both. The pro-EMT agent is octanoic acid, octanoate salt or a combination thereof. The anti-EMT agent is a C9-C14 fatty acid, a salt of C9-C14 fatty acid, a monoglyceride of C9-C14 fatty acid, a diglyceride of C9-C14 fatty acid, a triglyceride of C9-C14 fatty acid, or a combination thereof. Use of such albumin compositions for various therapeutic applications based on albumin, and more particularly for the treatment of diseases or conditions in which EMT should be prevented or minimized. These albumin compositions can advantageously be used in combination with known active ingredients. Also, described are composition of an anti-EMT agent for use in the treatment of various therapeutic indications, and more particularly for the treatment of diseases or conditions where EMT should be prevented or minimized.
PURPOSE: Although the treatment of abdominal wall desmoid-type fibromatosis (DF) has evolved over the past decades, surgical treatment remains an important approach. Previously, surgeries for abdominal DF were mostly performed by laparotomy, which involves massive dissection and significant trauma. Here, we report our single-center experience of the laparoscopic management of abdominal wall DF in young female patients.
METHODS: The clinical data of nine patients diagnosed with abdominal wall DF during January 2020-April 2022 at the Qilu Hospital of Shandong University were retrospectively analyzed. All patients underwent laparoscopic resection of abdominal wall DF and immediate abdominal wall reconstruction (AWR) with mesh augmentation via the intraperitoneal onlay mesh (IPOM) technique.
RESULTS: Laparoscopic DF resection and AWR were successfully performed in all patients. The mean operation time was 175.56 ± 46.20 min. The width of abdominal wall defect was 8.61 ± 3.30 cm. Full- and partial-thickness myofascial closure and reapproximation were performed in five, two, and two patients, respectively. The average mesh size was 253.33 ± 71.01 cm2. The total and postoperative lengths of hospital stay were 11.00 ± 3.46 and 4.89 ± 2.03 days, respectively. Tumor recurred in one patient after 20 months of the resection. Nonetheless, death, herniation, or bulging were not observed in any patient during a mean follow-up of 16.11 ± 8.43 months.
CONCLUSION: Laparoscopic resection of abdominal wall DF and immediate AWR with IPOM mesh reinforcement is safe and reliable for young female patients. Management of such patients should be decided according to the biological behavior, size, and location of tumors.
Methods for the production of steroids (sapogenins) and steroidal glycosides (saponins) from cell, root-cell and shoot tissue cultures of the Yucca plant. The cultures were established and maintained in a suitable nutrient plant cell medium supplemented with growth regulators. The desired products are extracted from the cultures using conventional extraction techniques. Greater total production of steroidal glycosides occurred in root-cell, cell, and shoot tissue cultures in that order. Although the cultures may be grown under conditions ranging from total darkness to total light, steroidal glycoside production was highest in root-cell cultures grown continuously in the light as compared to those grown in the dark. Root-cell culture senescence also enhanced the yield of total steroidal glycosides. Steroids are obtained from the steroidal glycosides by acid hydrolysis to remove the sugar moieties. The production of radio-labeled steroids and steroidal glycosides is disclosed.
The patients in the experimental arm will receive radical resection of the primary lesion only, with neck observation, the safety margins of the primary lesion are 1.0-1.5cm far away from the palpable margins of the lesion. Ultrasonography, CT scan, and/or MRI examination will be used to detect lesions.
PURPOSE:To obtain a safe composition for the head, containing magnesium (meta)silicate aluminate and having deodorant effects, skin waste product adsorptivity, peroxide lipid adsorptivity, etc., and excellent in usability without swelling even if water is contained. CONSTITUTION:A composition for the head obtained by blending magnesium (meta)silicate aluminate, magnesium silicate aluminate or coated powder prepared by coating the surface of a powder core with the aforementioned compound or the above-mentioned compound and one or two or more other powders in an amount of 0.1-100wt.% in the composition. The particle diameter of the aforementioned compound is preferably 0.005-500mum and the coated powder has preferably 0.1-500mum particle diameter. In preparing the coated powder, the above-mentioned compound having a particle diameter of <=1/5, especially <=1/10 based on that of the powder to be a core is used in an amount of preferably 1-200 pts.wt. based on 100 pts.wt. powder to be the core.
A diagnosis of COPD was made by a clinical history, examination and spirometer (forced expiratory volume in 1st second/forced vital capacity (FEV1/FVC)ratio of \<0.7). The severity of COPD was graded according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. \[9\] (Stage I, mild COPD: FEV1≥80.0% predicted; Stage II, moderate COPD: FEV1 80-50.0%; Stage III, severe COPD: FEV1 50- 30.0%; Stage IV, very severe COPD: FEV1\< 30.0%). The exacerbation of COPD was defined as the patient being diagnosed with COPD with two or more of the following three symptoms of exacerbations: new or worsening cough, worsened dyspnea, and worsened sputum volume and/or change in its color.
The invention discloses a method for preparing a powdery nanoscale traditional Chinese medicine microecological regulator by a double coating low-temperature freeze-drying technology. The method provided by the invention comprises the following steps of adding a microecological regulator into starch, carrying out first coating and fragmentation by an ultrasonic fragmentation method, adding silk fibroin and chitosan into slurry obtained by the first coating, carrying out ball milling, and carrying out secondary coating so that nanocrystallization is realized. The powdery nano-traditional Chinese medicine microecological regulator coats the microecological regulator having effects of inhibiting bacteria and agglomeration and growth of nano-traditional Chinese medicine particles, can improve immunity and can promote nano-traditional Chinese medicine absorption. The used microecological regulator is a microecological regulator solution obtained by active ingredient extraction and through ultrasonic fragmentation and ball milling, nanocrystallization is realized and absorption effects and efficacy are improved. The powdery nanoscale traditional Chinese medicine microecological regulator is prepared by the double coating low-temperature freeze-drying technology. Particle sizes of the powdery nanoscale traditional Chinese medicine microecological regulator are in a range of 20 to 100nm. The powdery nanoscale traditional Chinese medicine microecological regulator can be utilized for microecological regulation of a dose. The powdery nanoscale traditional Chinese medicine microecological regulator has uniform components, a low raw medicine loss and a low moisture adsorbability by multilayer coating of particles, can contain particles having different sizes by technical control, is crisp, and can be processed into medicinal particles and medicinal tablets.
Weekly escalation of cabergoline dose in macroprolactinomas Start with 1 mg/week. increase by 1mg/wk every week till 4 weeks. after 4 weeks Cabergoline dose would be increased @1mg/wk every 4 weekly till normalization of prolactin and \>50% decrease in tumor volume from baseline.
The participants will be individuals who apply to the Allergy and Immunology Clinic of Istanbul Sureyyapasa Chest Diseases and Surgery Training and Research Hospital, have been diagnosed with asthma for at least one year and agree to participate in the study. It will consist of people who are between the ages of 18-65, understand Turkish, know how to read and write. Twenty five people selected by the randomization table method will be in the control group. They will be given the Ministry of Health's asthma education brochure. As in the intervention group, pre-test and post-test will be conducted.
Subjects with diabetes (or parents/guardians, if applicable)and healthcare professionals (HCPs) use a new blood glucose monitoring system. Subjects were 4 to 24 years of age with type 1 and type 2 diabetes.
BACKGROUND: The antimicrobial ribonuclease RNase 7 is abundantly expressed in the epidermis of lesional skin of atopic dermatitis (AD). Host RNase inhibitor (RI) binds to RNase 7 and blocks its ribonuclease activity. This study aimed to evaluate the impact of RNase 7-RI interactions on AD.
METHODS: Cultured human primary keratinocytes, with siRNA-mediated downregulation of RNase 7 and RI, were stimulated with the synthetic RNA polyinosinic-polycytidylic acid (poly I:C). Induction of proinflammatory mediators was analyzed by real-time PCR and ELISA. RI expression in AD non-lesional and lesional skin biopsies and healthy controls was analyzed by real-time PCR and immunostaining. RI protein release in vivo on the AD skin surface was determined by western blot. Antimicrobial and ribonuclease assays were used to investigate the functional role of RI.
RESULTS: RNase 7 inhibited the RNA-induced expression of proinflammatory mediators in keratinocytes. Accordingly, downregulation of RNase 7 in keratinocytes enhanced RNA-mediated induction of proinflammatory mediators, whereas downregulation of RI had the opposite effect. RI was released by damaged keratinocytes and epidermis. In vivo expression and release of RI on the skin surface were enhanced in lesional AD skin. Rinsing solution from the surface of lesional AD skin blocked the ribonuclease activity of RNase 7. The anti-Staphylococcus aureus activity of RNase 7 was abrogated by RI.
CONCLUSIONS: Our data suggest a novel role of RI as a trigger factor of inflammation in AD by blocking the ribonuclease and antimicrobial activity of RNase 7, thereby enhancing RNA-mediated inflammation and S. aureus growth.
FF(100mcg)/Vilanterol(25mcg) in the morning (approx 09.00) for 14 days (± 2 days).; placebo in evening (approx 21.00) for 14 days (± 2 days).
PURPOSE:To use the titled matter as a detecting reagent of various antigens or antibodies without deterioration in spite of long store and reduction of detecting sensitivity by lyophilizing red blood cells, especially red blood cells sensitive for the antigens or antibodies, together with albumin at a specific rate. CONSTITUTION:In order to prepare 2%(w/v) or more solution, albumin is added to a suspended solution such as 5%(w/v) physiological saline solution of fixed blood cells treated with the blood cells of Mammaria (humans, horses, rabbits, etc.), birds (chickens, etc.), reptiles, etc. which are sensitive for antigents or antibodies, H2CO, tartardialdehyde, etc. or the mixture is lyophilized. The lyophilized matter is suspended again to use it for the blood sedimentation reaction. The sedimentation image is the same as that before the lyophilization. The image is not changed even when the lyophilized matter is used by suspending again after long storage and has superior sensitivity.