anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Hair-fixing compositions comprise as film-forming substance a polyvinyl acetal the 5% butanol solution of which has a viscosity of less than 50 centipoises and which has so high a content of hydroxyl groups that it has only a limited capacity for absorbing water but is nevertheless soluble or dispersible in dilute aqueous solutions of wetting agents, i.e. shampoos. Specified acetals are those of acetaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, caproaldehyde and caprylaldehyde. Minor proportions of residual acylate, e.g. acetate, groups and acetal groups derived from higher aldehydes may be present. Specified solvents are ethanol and isopropanol, and the compositions may also comprise wetting agents, softening agents, perfumes, dyes and propellants, e.g. trichlorofluoromethane, dichlorodifluoromethane and dichlorotetrafluoroethane. Examples describe compositions comprising perfume and a propellant and (1) polyvinyl butyral, alcohol-soluble lanoline and isopropanol; (2) polyvinyl acetal, isopropanol and methylene chloride; and (3) polyvinyl butyral, ethanol and methylene chloride.ALSO:A method of fixing hair comprises spraying on to the hair a solution containing, as film forming substance, a polyvinyl acetal, the 5% butanol solution of which has a viscosity of less than 50 centipoises and which has so high a content of hydroxyl groups that it has only a limited capacity for absorbing water but is soluble or dispersible in dilute aqueous solutions of wetting agents, i.e. in shampoos.  The glossy films obtained remain unchanged by humid atmospheres, are undamaged by combing and minimize electrostatic charging.  Specified acetals are those of acetaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, caproaldehyde and caprylaldehyde.  Minor proportions of residual acylate groups, e.g. acetate groups, and acetal groups derived from higher aldehydes may be present.  Specified solvents are ethanol and isopropanol, and the compositions may also comprise wetting agents, softening agents, perfumes, dyes and propellants, e.g. trichlorofluoromethane, dichlorodifluoromethane and dichlorotetrafluoroethane.  Examples describe spraying hair with compositions comprising perfume and a propellant and (1) polyvinyl butyral, alcoholsoluble lanoline and isopropanol; (2) polyvinyl acetal, isopropanol and methylene chloride; and (3) polyvinyl butyral, ethanol and methylene chloride.
OBJECTIVES: Invasive fungal super-infection (IFSI) is an added diagnostic and therapeutic dilemma. We aimed to develop and assess a nomogram of IFSI in patients with healthcare-associated bacterial infection (HABI).
METHODS: An ambispective cohort study was conducted in ICU patients with HABI from a tertiary hospital of China. Predictors of IFSI were selected by both the least absolute shrinkage and selection operator (LASSO) method and the two-way stepwise method. The predictive performance of two models built by logistic regression was internal-validated and compared. Then external validity was assessed and a web-based nomogram was deployed.
RESULTS: Between Jan 1, 2019 and June 30, 2023, 12,305 patients with HABI were screened in 14 ICUs, of whom 372 (3.0%) developed IFSI. Among the fungal strains causing IFSI, the most common was C.albicans (34.7%) with a decreasing proportion, followed by C.tropicalis (30.9%), A.fumigatus (13.9%) and C.glabrata (10.1%) with increasing proportions year by year. Compared with LASSO-model that included five predictors (combination of priority antimicrobials, immunosuppressant, MDRO, aCCI and S.aureus), the discriminability of stepwise-model was improved by 6.8% after adding two more predictors of COVID-19 and microbiological test before antibiotics use (P<0.01).And the stepwise-model showed similar discriminability in the derivation (the area under curve, AUC=0.87) and external validation cohorts (AUC=0.84, P=0.46). No significant gaps existed between the proportion of actual diagnosed IFSI and the frequency of IFSI predicted by both two models in derivation cohort and by stepwise-model in external validation cohort (P=0.16, 0.30 and 0.35, respectively).
CONCLUSION: The incidence of IFSI in ICU patients with HABI appeared to be a temporal rising, and our externally validated nomogram will facilitate the development of targeted and timely prevention and control measures based on specific risks of IFSI.
INTRODUCTION: Osteoporotic vertebral compression fracture (OVCF) is a common complication in elderly patients with osteoporosis. Despite undergoing percutaneous kyphoplasty (PKP) treatment, a significant percentage of OVCF patients (1.8% to 31.9%) continue to experience residual low back pain. While acupuncture has shown promise in relieving this pain, there is currently no systematic review on its efficacy specifically for residual low back pain after PKP in OVCF patients. This project aims to evaluate the effectiveness and safety of acupuncture as a treatment for this condition.
METHODS AND ANALYSIS: A comprehensive search will be conducted, including manual and electronic searches of literature published. Various databases such as MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library, International Clinical Trial Registration Platform, China National Knowledge Network, China Biomedical Literature Database, China Scientific Journal Database and Wan-fang Database will be explored. Additional sources like bibliographies and meeting minutes will also be searched. All randomised controlled clinical trials related to acupuncture for treating residual low back pain after PKP in OVCF patients will be included. Two researchers will independently perform study selection, data extraction and quality assessment. The primary outcome measure will be pain relief assessed using a visual analogue scale (VAS) or other validated scales. Secondary outcomes include effectiveness, Oswestry dysfunction index (ODI), quality of life questionnaire (QUALEFFO-41), follow-up relapse rate and adverse events. If feasible, a meta-analysis using RevMan V.5.3 software will be conducted. Otherwise, descriptive or subgroup analyses will be performed. Database searches will commence after the publication of this agreement, with an estimated commencement date of 1 August 2024.
ETHICS AND DISSEMINATION: Ethical approval is not required since this review does not involve individual patient data. The findings will be disseminated through peer-reviewed journals or relevant conferences.
PROSPERO REGISTRATION NUMBER: CRD42023478838.
The invention discloses a preparation method and application of a hollow procyanidine wall material microcapsule. Procyanidins are a plant polyphenol compound with good antibacterial, antioxidant and anticancer cell activities. Procyanidins are widely found in the bark of darker fruits and plants. However, procyanidins do not have a fixed spatial stereo-morphology and are readily soluble in polar solvents, so that the use of ordinary procyanidins in encapsulation applications is limited. The hollow procyanidin microcapsule provided by the invention is prepared by taking ZIF-8 as a sacrificial template and procyanidin as an etching agent to etch the ZIF-8, and finally the hollow procyanidin wall material microcapsule with the particle size of about 200 nanometers is obtained. The cedar essential oil is embedded by hollow procyanidin wall material microcapsules, and finally the cedar essential oil slow-release microcapsules with the loading capacity of about 26% are obtained. The invention successfully constructs the hollow microcapsule taking the procyanidin as the wall material, and can be used in the field of embedding of medicaments or essential oil which are easy to oxidize and deteriorate.
The Human Papilloma Virus (HPV) causes cervical cancer. HPV is an infectious disease. Currently, safe and effective HPV vaccines are available for women 9-45 years of age in China. The transition between grade school and middle school is a particularly good time to think about the HPV vaccine.
A system for determining patient eligibility and compliance with a medical protocol includes a medical protocol library containing information relating to a plurality of medical protocols. The information includes eligibility rules and compliance rules for each of the plurality of medical protocols. Each compliance rule has one or more parameters. The system has a sensor and medical device interface. The received patient data relates to the eligibility rules and/or the compliance rules for at least one of the medical protocols. A protocol eligibility module is configured to determine patient eligibility as a function of the received patient data and the eligibility rules relating to the at least one protocol. A protocol compliance module is configured to determine, after the at least one patient is enrolled in an active protocol, a dynamic concordance rate of the at least one patient.
Recent studies demonstrated that in-hospital emergencies are linked to a higher mortality in patients. In total, 1 out of 10 patients is suffering from an unexpected incident during the hospital stay. Therefore, establishing and developing medical emergency teams (MET) is getting more important in the future. Aim of the present study was an analysis of medical documentation, operational tactics and procedures taken by MET in a 4-year-period, ranging from 2013 to 2016. A retrospective analysis of 1,664 emergency forms from MET activities, ranging from January 2013 to December 2016. Every MET activation call via the emergency telephone number ("5555") and following emergency treatment was recorded by a standardized documentation form.
PURPOSE: To obtain a cosmetic compsn. which is prepared by incorporating a cosmetic component into polymer latex particles of a specified particle size and which is excellent in adhesion property to hair and skin and useful for a hair shampoo and the like. CONSTITUTION: This cosmetic compsn. is prepared by incorporating or depositing (A) one or more kinds of cosmetic components such as a sunscreen, occlusion oil, dermatologic palliative, and humectant to be deposited on hair or skin into or on (B) polymer latex particles having <1 μm particle size, preferably 0.01 to 1 μm particle size. The amt. of the polymer latex particles used is preferably 2 to 20 wt.% of the compsn.
OBJECTIVE: To investigate the long-term outcomes of fornix reconstruction and cicatricial entropion repair in patients with ocular mucous membrane pemphigoid (MMP) and secondary MMP.
METHODS: Retrospective chart review of patients with MMP undergoing either fornix reconstruction (with amniotic membrane or buccal mucosal graft) or Wies cicatricial entropion repair between January 1, 2000, and September 1, 2020. Patients had a positive mucosal biopsy and (or) clinical features of MMP or secondary MMP. The primary outcome was overall success of fornix reconstruction based on fornix depth maintenance at latest follow-up. Secondary outcomes included resolution of trichiasis, visual acuity, and improvement of subjective symptoms.
RESULTS: Eight patients (10 eyes) with a diagnosis of MMP (3 males and 5 females; median age, 71 years) and 4 patients (4 eyes) with a diagnosis of secondary MMP (2 females and 2 male; median age, 87 years) were enrolled. Mean follow-up was 22.7 months (range, 0.3-87.5 months) for MMP patients and 15.4 months (range, 3.0-43.9 months) for secondary MMP patients. For MMP eyes, 30.0% underwent fornix reconstruction, 60.0% underwent entropion repair, and 10.0% received both. Re-formation of symblepharon and loss of fornix depth occurred in all MMP eyes at an average of 6.4 ± 7.0 months postoperatively, and trichiasis recurred in all patients at the last follow-up visit. In secondary MMP patients, 75.0% of the eyes showed recurrence of symblepharon, and 66.7% re-formed trichiasis. Both MMP and secondary MMP patients had short-term symptom improvements.
CONCLUSIONS: Fornix reconstruction and cicatricial entropion repair in our cohort of MMP and secondary MMP patients resulted in short-term symptomatic improvement, but recurrence was seen, on average, at 6 months postoperatively.
OBJECTIVES: Back pain during pregnancy is a common issue that impacts the quality of life for many women. YouTube has become an increasingly popular source of health information. Pregnant women often turn to YouTube for advice on managing back pain, but the quality of available videos is highly variable. This study aimed to assess the quality and comprehensiveness of YouTube videos related to back pain during pregnancy.
METHODS: A YouTube search was conducted using the keyword "back pain in pregnancy", and the first 100 resulting videos were included in the study. After a thorough review and exclusion of ineligible videos, the final sample consisted of 71 videos. Various parameters such as the number of views, likes, viewer interaction, video age, uploaded source (healthcare or nonhealthcare), and video length were evaluated for all videos.
RESULTS: Regarding the source of the videos, 44 (61.9%) were created by healthcare professionals, while 27 (38%) were created by nonprofessionals. Videos created by healthcare professionals had significantly higher scores in terms of DISCERN score, Journal of the American Medical Association (JAMA) score, and Global Quality Scale (GQS) (P < 0.001). Our findings indicate a statistically significant and strong positive correlation among the three scoring systems (P < 0.001).
CONCLUSION: Videos created by healthcare professionals were generally of higher quality, but many videos were still rated as low-moderate quality. The majority of videos focused on self-care strategies, with fewer discussing other treatment options. Our findings highlight the need for improved quality and comprehensiveness of YouTube videos on back pain during pregnancy.
Spit tobacco presents as many health risks to its users as smoking tobacco. Although a significant number of ST users recognize the importance of quitting, many either do not want to quit or feel it is impossible. For these individuals, tobacco reduction may be an important transitional goal, either prior to quitting or as a treatment endpoint. However, approaches to help ST users reach this goal have not been studied. This study will assess the effectiveness of using tobacco-free snuff in reducing levels of exposure to tobacco and associated toxicity, as well as enhancing motivation to either quit or sustain lower levels of nicotine intake.

Participants will be randomly assigned to receive either treatment with tobacco-free snuff or treatment without it. All participants will be encouraged to reduce nicotine intake by 50% during the first four weeks and by 75% the following four weeks. Participants receiving the tobacco-free snuff will be asked to alternate the use of their usual brand of ST with tobacco-free snuff in order to achieve the targeted reduction. Participants not receiving the tobacco-free snuff will only be informed to try to cut down their tobacco use to the targeted reduction. Study visits will occur once weekly during the 8-week treatment period. Assessments will include vital signs, physiological measures related to tobacco use, and measures of motivation and self-efficacy to quit ST. The number of participants who either do not complete treatment, reduce nicotine intake, or quit completely will be assessed at the Week 8 study visit and at follow-up visits, which will be held at Weeks 12 and 26.
This is a prospective, non-randomized, non-blinded comparative study.

There will be no changes to the anesthetic or surgical plan to accommodate this study. Patients undergoing anesthesia will be induced per their anesthetic team. Following endotracheal intubation, the patient will be placed on air (FiO2 21%) at 4 liters per minute fresh gas flow. After a minimum of 3 minutes has elapsed, the anesthesia team will obtain an arterial blood sample of approximately 1 mL. This can be obtained from an arterial line if one is planned for the procedure or already in place by accessing the line per standard procedure. If an arterial line is not placed, the arterial sample will be obtained by percutaneous arterial puncture using ultrasound guidance and a 25-gauge blood gas syringe. The patient's SpO2 will be noted using a pulse oximetry probe placed on the right index finger when the arterial sample is drawn, along with the date/time of sample acquisition. Once the sample is drawn, the patient's anesthetic and surgery will proceed as per his anesthesia team. The arterial sample will be immediately delivered to the Nationwide Children's Hospital laboratory for simultaneous ABG and ABG-CoOx analysis to obtain SaO2S and SaO2C, respectively.
PURPOSE:To prepare a composition for oral cavity, having high aseptic activity and excellent storage stability, by adding a surface active agent to a base containing a water-soluble calcium salt. CONSTITUTION:A water-soluble calcium salt having a solubility of >=0.3wt%, especially >=1wt% in distilled water at 25 deg.C (preferably calcium lactate or calcium gluconate) is dissolved or dispersed in water or a water-containing liquid, and the solution or dispersion is mixed with other ingredients to obtain a base of the composition for oral cavity. The obtained base is incorporated with a surface active agent, preferably an anionic surface active agent (especially alkyl sulfuric acid ester metal salt) or a nonionic surface active agent (especially sucrose fatty acid ester). The preferable amounts of the calcium salt and the surface active agent are 0.5-5wt% and 0.1-5wt%, respectively, based on the whole composition. Addition of 0.01-1wt% of p-hydroxybenzoic acid alkyl ester (especially methyl ester) improves the aseptic activity without deteriorating the taste, etc. of the product.
Long-course chemoradiation followed by PD-1 inhibition (Sintilimab 200mg, 3 times, 2-week interval) starting on Day 15 after completion of radiation therapy. TME surgery is scheduled in 6 weeks after completion of radiation.
BACKGROUND: Little is known about the long-term impact of hearing and vision impairment on social isolation. This study quantifies the association between hearing, vision, and concurrent hearing and vision impairment (dual sensory impairment) and social isolation over 8 years among older adults.
METHODS: Data were from the National Health and Aging Trends Study (NHATS), a cohort study (2011 - 2019) of U.S. Medicare beneficiaries aged 65 years and older. Social isolation was measured by a binary indicator incorporating four domains: living arrangement, core discussion network size, religious attendance, and social participation. Hearing, vision, and dual sensory impairments were measured by self-report and modeled categorically (no impairment [ref.], hearing impairment only, vision impairment only, dual sensory impairment). Associations between sensory impairments and odds of social isolation over 8 years were assessed using multivariate generalized logistic mixed models and adjusted for demographic and health characteristics.
RESULTS: Among 5,552 participants, 18.9% self-reported hearing impairment, 4.8% self-reported vision impairment, and 2.3% self-reported dual sensory impairment. Over 8 years, hearing impairment only was associated with 28% greater odds of social isolation. Participants with hearing impairment only were more likely to live alone and have limited social participation.
CONCLUSION: Greater clinical awareness of hearing impairment as a risk factor for social isolation can increase opportunities to identify and aid older adults who may benefit from resources and interventions to increase social connection and mitigate social isolation.
Potassium nitrate (KNO3) is a superior desensitizer for hypersensitive teeth. Used with polycarboxylate cement, it serves as an effective liner for deep carious lesions. Also when placed under deep restorations with less than 1 mm of protective dentin remaining, it was effective in preserving pulpal vitality and it diminished the incidence and severity of post-restoration pain. As temporary cement (Kno3/zinc oxide eugenol \[ZOE\]) It reduced pain following full crown preparation.
Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 28 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI and collection of blood samples throughout the trial.
Aripiprazole oral solution (1mg/mL) for 12 weeks. dosages range from 2-10mg per day.
Anticoagulant therapy can significantly reduce the incidence of stroke and peripheral embolism events in patients with atrial fibrillation (AF). Although warfarin is widely used as an anticoagulant drug, a wrong dose can lead to increased risks of bleeding or blood clots. The aim of this study was to assess whether nuclear factor-erythroid-2-related factor 2 (Nrf2) can improve the efficacy of warfarin through the regulation of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) using a rat model of AF. Results showed that AF significantly reduced Nrf2 in myocardial tissue of sham-operated rats. Furthermore, Nrf2 overexpression effectively reduced AF-induced atrial fibrosis by reducing collagen in the left atrium, inhibiting the expression of the fibrosis-related genes collagen I and transforming growth factor-β1 in rats with AF. Nrf2 overexpression can activate CYP2C9, decrease the serum concentration of warfarin, and decrease prothrombin time and international normalized ratio in AF rats. In this article, Nrf2 overexpression protects against fibrosis, increased survival in AF rats, and activated CYP2C9 expression, thus broadening the therapeutic range of warfarin in AF rats.
28 year old male patient previously healthy presented with diarrhea and diffuse abdominal pain of 1 week duration that exacerbated 1 day prior to presentation. CT showed anterior abdominal mass possibly from the outer gastric wall. Gastroscopy suspected a submucosal tumor in the body and antrum. Patient's pain exacerbated and developed drop in hemoglobin. Urgent CT scan showed a bleeding gastric tumor. Urgent laparotomy identified a bleeding gastric lesion at greater curvature. Partial gastrectomy done with abutting mesocolon resection. Surgical specimen pathology showed gastric intramural hematoma that was considered spontaneous.