anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Significant interindividual variability in spinal cord stimulation (SCS) outcomes exists. Due to its high cost and risks of complications, criteria to guide patient selection for SCS trials and their outcomes would be helpful. With increased focus on the use of patient-reported outcomes to improve care, we aim to evaluate the National Institute of Health Patient Reported Outcome Measurement Information System measures for an association with successful SCS trials in patients with persistent pain.
METHODS: Our prospective, observational study enrolled 60 patients with persistent pain who underwent an SCS trial. Patients completed demographic and Patient Reported Outcome Measurement Information System computer adaptive test (PROMIS CAT) assessments to measure self-reported pain interference, depression, anxiety, physical functioning, and sleep disturbance at the time they presented for placement of their trial device.
RESULTS: Of the 58 patients who underwent successful electrode placement, 11 had an unsuccessful trial. There were no differences in patient demographics between patients with a successful and an unsuccessful trial. Patients who had a successful SCS trial reported lower pre-trial levels of anxiety, depression, and sleep disturbance and decreased post-trial levels of depression, sleep disturbance, and pain interference.
CONCLUSIONS: We found that patients with high levels of depression, anxiety, and sleep disturbance using the PROMIS CAT were predictive of unsuccessful trials. In addition, we found that patients with successful SCS trials reported lower levels of these domains on PROMIS CAT administered at the end of the trial.
The invention relates to the technical field of medicine and pharmacy and discloses an injection solution of oxiracetam composition and a preparation method thereof. The injection solution of oxiracetam composition contains, per mL, 200 mg of oxiracetam, 0.05 mg of disodium ethylenediaminetetraacetate, 5 mg of sodium dihydrogen phosphate, 0.1 v/v% of chlorobutanol and the balance of water for injection. Chlorobutanol can not only relieve pain and inhibit reproduction of microorganisms but also enhance the memory-improving effect of oxiracetam. The trials show that the injection solution of oxiracetam composition can improve memory and learning capability and has good stability. The injection solution of oxiracetam composition can be widely applied to improve brain metabolism, relieve brain dysfunction and memory disorders in seniors and treat neurosis and mental and behavior disorders, particularly senile dementia. The injection solution of oxiracetam composition can also be used for rehabilitation of brain trauma, encephalitis and other brain diseases.
The intervention group will take part in a group-based mindfulness-based stress reduction (MBSR) program led by a certified MBSR instructor via Zoom. This MBSR program will have a shortened session length of 1.5 hours compared to the traditional 2 hours, to reduce caregiver burden. Caregivers will be trained in meditation practices, like awareness of one's breath, body scan, and loving kindness meditation. Participants will also learn about mindfulness and stress theory, and have group discussions covering topics such as self-compassion.
This research was conducted to evaluate the impact of the Problem Solving and Decision Making Training program, which was developed to enhance the problem-solving and decision-making skills of nurse managers at the lower, middle, and upper levels, by the subordinates and superiors of nurse managers. To assess the problem-solving and decision-making skills of nurse managers as perceived by their subordinates, the Problem-Solving Inventory-Managerial Version (PSI-MV) and Decision-Making Styles Scale-Managerial Version (DMSS-MV) underwent adaptation, validity, and reliability studies. These studies aimed to enable the evaluation of nurse managers' problem-solving and decision-making abilities from the perspective of their subordinates. The study was carried out using a systematic and randomized controlled design, incorporating elements such as pre-test-post-test, experimental, and control groups. In the initial phase of the research, the target population comprised 2,108 nurses employed at a city hospital in Istanbul, while the actual sample included 328 nurses. The validity and reliability studies of PSI-MV and DMSS-MV were carried out. In the scale analyses, psycholinguistic and psychometric properties were examined. In the second part of the research, a sample of 300 nurses, including 60 nurse managers and their subordinates (30 in the experimental group and 30 in the control group), was included using G\*Power analysis for sample calculation.
<P>PROBLEM TO BE SOLVED: To develop endocytosis-sensitive probes, and to provide a remote measuring method of cellular endocytosis.  <P>SOLUTION: The probes are based on a nanoparticle or liposomal delivery system of the reduced water permeability, and inherent degradability or disruption of barrier integrity upon endocytosis. There are also provided for liposomes combinedly having therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. There are provided for imaging methods of therapeutic liposomes by inserting a lipopolymer anchoring the remotely sensing reporter molecules into liposomal lipid layer. There are provided for an integrated delivery system enabling the imaging of molecular fingerprints in diseased tissues, the treatment, and the treatment monitoring.  <P>COPYRIGHT: (C)2011,JPO&INPIT
317,327. I. G. Farbenindustrie Akt.- Ges. Aug. 13, 1928, [Convention date]. Addition to 302,337. Medicines for internal use.-The process described in the parent Specification for the manufacture of a stable liquid preparation of tribromoethyl alcohol which is soluble in water, by adding amylene hydrate thereto, is modified by replacing the amylene hydrate by another tertiary alcohol or by a secondary alcohol. Preparations specified contain respectively trimethyl carbinol 1 part, tribromoethyl alcohol 3 parts; and isopropyl alcohol 1 part, tribromoethyl alcohol 4 parts. The preparations may be exposed to light and to a temperature of 100‹ C. without decomposition. Preparations made with ethyl alcohol, glycol, or glycerine are referred to, but are stated to be unstable.
The invention relates to a method for treating skin diseases using live "Penicillium notatum" fungus. There is still little known about the "Penicillium notatum" fungus. Live "Penicillium notatum" fungus acts in the following ways in the treatment process: 1) as a biological producer of the most effective antibiotic against (particular) pathogenic microorganisms which act as the causative agents of a particular disease; 2) as a biological therapeutic vehicle for the efficient delivery of an antibiotic individually to each pathogenic microorganism; 3) as a biological vehicle for the removal of dead and infected human body tissue; 4) as a biological immunizing agent that protects young, regenerating skin; 5) as a biological immunizing agent that protects young skin tissue that has not established immunity against repeated attack from the disease following regeneration. The treatment period for certain infectious skin diseases using live "Penicillium notatum" fungus lasts from three to five days. In the future, it is possible that the live fungus "Penicillium notatum" is used to augment the immunity lost by people under various specific circumstances, such as specific conditions of work and day-to-day activity, a prolonged period in space, loss or reduction in constant gravitational weight, impaired individual immunity caused by space-related factors, and the emergence of new diseases. It can supplement or replace the immunizing microflora of human internal organs. It is likely that the fungus will be domesticated and new species thereof artificially derived specifically for each organ of the human body. It is essential that mankind learns how to use the live fungus "Penicillium notatum" in the field of medicine in view of the fact that its resilience exceeds that of all life forms known to mankind, including the resilience of the microorganisms of the immunizing human microflora.
OBJECTIVES: Children born with moderate hearing loss present with speech and language outcomes at both ends of the spectrum. To explore reasons for this, the objective of this study was to follow up a group of children born with moderate sensorineural hearing loss at 6 years of age (n = 7) by investigating their outcomes in hearing, speech, and language development from time point of hearing aid fitting at 6 months. Another objective was to investigate the relationship between earlier outcomes on precursing variables to the current status in auditory, speech and language development.
METHOD: Earlier data from a project with the same participants of auditory variables, speech, and language development were compared to the current study outcomes at 6 years of age. Children in this study performed standardized tests of phonology (SVANTE), expressive vocabulary (BNT), and speech-in-noise test (Hagerman's sentences). Parents reported on their child's functional auditory performance in everyday life (PEACH), and demographics and general development (questionnaire). Etiology and frequency of speech and language-directed intervention from time point of diagnosis to 6 years of age were collected through medical journals.
RESULTS: Hearing levels were stable over time in all children but one, who had received bilateral cochlear implants. Performance on speech-in-noise testing varied in aided condition (-0.8 to 8, mean 2.65, SD 3.09) and unaided condition (7.2 dB-21.2 dB, mean 12.06, SD 4.82). Scores on the PEACH indicated further review in four of the seven children. Mean group score on consonant proficiency had increased from 3 to 6 years of age and were within age norms. Vocabulary scores were below the norms of children with typical hearing. Outcomes on vocabulary measures at 2.5 years showed strong correlations that were significant to scores on the BNT at 6 years of age (r = 0.87, p = 0.05). Correlations between hours of hearing aid use and vocabulary was not significant at 6 years of age. The frequency of intervention sessions in the first 6 years varied between participants (4-55, mean 19.1, SD 17.1).
CONCLUSION: Despite homogeneous hearing and other background variables in the participants from birth, large individual variations in speech and language outcomes at 6 years of age were found. Considering the many factors involved that impact the development of children with moderate hearing loss, the results suggest that monitoring early precursors in auditory, speech and language development may be helpful in setting commensurate goals for each child. Detecting additional conditions that may pose challenges in future speech and language as early as possible is important. There is ample room for improvement in terms of increasing the frequency of intervention for children with moderate hearing loss and their families.
A retrospective analysis of above-mentioned data, covering the period January-April 2019 and January-April 2020, was carried out. The evaluation of the staff's absence included all workers employed under an employment contract: 713 workers in 2019 and 747 workers in 2020. The variable number of employees was a result of the employment dynamics in the subsequent 2 years, due to variable quantity of healthcare services that were contracted with the national payer and changes in the form of employment of some hospital workers.Three types of analyses were carried out: global analysis, analysis taking into account division into specific professions and the analysis of absence in different hospital organizational units/areas. The absences due to medical reasons, holidays or childcare were analyzed together. The analysis of performing the contracted tasks was shown in relative values ( %). The analysis included the structure of contracted services dividing them into: Orthopedics (alloplasty and others), rehabilitation (person-day), rheumatology (drug trials and others). Considering the rehabilitation unit, it was subdivided into inpatient and outpatient wards due to temporary closure of the outpatient ward.
The active agent-application device (1) for application in a gastro-intestinal tract, in a bladder or in uterus, comprises application mechanism (2) loaded with the agent, and a holding mechanism (6) for the application mechanism. The holding mechanism holds the application mechanism in a normal position as long as the mechanism is in an application position and enables to displace the application mechanism of the application position into delivery position of the agent. In the delivery position, the mechanism exhibits a typical cross section extending. The active agent-application device (1) for application in a gastro-intestinal tract, in a bladder or in uterus, comprises application mechanism (2) loaded with the agent, and a holding mechanism (6) for the application mechanism. The holding mechanism holds the application mechanism in a normal position as long as the mechanism is in an application position and enables to displace the mechanism of the application position into delivery position of the agent. In the delivery position, the mechanism exhibits a typical cross section extending, which is 5-times of a minimum cross section extending in the application position. The mechanism is formed in such a way that it stands in connection with less than 5% of the interior wall area of the target organ, in the delivery position. The Application mechanism in the delivery position is present as net, whose maximal interior volume is larger than the interior volume of a target organ of the gastro-intestinal tract. A light width of meshes of the net is half of a largest organ-inlet opening of the target organ. The Application mechanism in the delivery position is present as spiral, whose maximum cross section extending is larger than the interior cross section of the target organ. The distance between adjoining windings of the spiral is a multiple diameter of a single strand developing the spiral. The mechanism is formed from mucoadhesive-single strand, which has rectangular cross section and which is carried out by multilayers. One of the layers of the single strand exhibits an active substance and a function material different from the active substance. The application mechanism is formed in such a way that in the delivery position, a central section of an interior lumen of the target organ is kept free.
Arterial pressure (AP) is one of the most important physiological variables. Particularly in emergency medicine, AP needs to be monitored repeatedly or even better, continuously. This is usually done using an oscillometric pressure device (NIBP). A number of studies emphasise the importance of continuous AP monitoring as more than 20% of all hypotensive episodes may be missed by NIBP and another 20% are detected with delay. Prolonged hypotension precedes 56% of perioperative cardiac arrests and is associated with a significant increase of the 1-year mortality rate, indicating that NBP monitoring especially in patients with cardiovascular diseases might be insufficient independent from the clinical setting. Recently, a monitor for continuous non-invasive AP monitoring (CNAP™ Monitor 500) was introduced. It was shown that during procedures with high risk of hypotension NIBP missed significant more hypotensive episodes than CNAP. At the moment we have no evidence of the performance of CNAP in the preclinical emergency medicine. The evaluation against the gold standard of invasive pressure measurement in this study will help us to evaluate the performance of CNAP in the preclinical setting.
The experiment group will be applied with the Z technique. While applying the medicine with the Z technique, the tissue will be lifted with the thumb and forefinger of the left hand and pulled to the right, and the medicine will be slowly applied after the injector needle enters the tissue. When the application is finished, first the injector will be withdrawn, then the tissue will be released and the tissues will be restored (Altun, 2018).
PURPOSE:To obtain a cosmetic having excellent quality characteristics in addition to sufficient antistatic properties. CONSTITUTION:At least either one in spongy powder and spongy fiber surface- treated with a hydrophobic agent is blended in cosmetic. As the spongy powder, powder having <=15mum average particle diameter and <=50mum maximum diameter is preferably adopted. As the spongy fiber, a fiber having 0.1-5.0mm fiber length is preferably adopted. Fine-particle or fibrous crushed material obtained by crushing a spongy tissue has action capable of preventing charge of pigment or powder as well as action capable of improving fitness with oily content, action capable of shielding ultraviolet rays and action (antibacterial properties) capable of suppressing proliferation, etc., of bacteria. The crushed material of the spongy tissue is compounded in the cosmetic to provide the object cosmetic having excellent quality characteristics.
Subjects, aged 6 months - 9 years, male or female, received 2 doses of Arepanrix™-formulation 2 (F2) vaccine administered at a 21-day interval. The first dose was administered intramuscularly in the deltoid region of the non-dominant arm (or left arm if dominance was not yet identified) or left anterolateral thigh (for children \< 12 months of age). The second vaccine dose was administered in the deltoid region of the dominant arm (or right arm) or right anterolateral thigh (children \< 12 months of age).
Sepsis is the number one cause of mortality in US hospitals. An aim of this study was to evaluate the ability of resident physicians with different training backgrounds to recognize SIRS, sepsis, and severe sepsis. A survey assessment of the definition of SIRS, sepsis, and severe sepsis was administered to internal medicine, emergency room, orthopedic, neurosurgery, and general surgery residents. Then, an intensive educational campaign designed to improve recognition of the patient with sepsis was launched. For approximately 1 year, posters with this educational information were displayed in the hospital, one-on-one educational sessions were provided to residents, and didactic sessions focusing on sepsis were conducted. The survey was then redesigned and administered it to the same groups as described previously.
This is a prospective, observational, non-significant risk study. The study involves using non-invasive devices that measure fetal depth and tissue light scattering on the maternal abdomen. Ultrasound assessment will be performed, and five images taken at the locations indicated on Figure 1. Depth to fetus will be recorded along with measurement of all distinctive layers. All images will be captured with minimal probe pressure applied to allow accurate ascertainment of depth. Images will be anonymized, and all study data will be coded with a unique identifier. Key maternal descriptive statistics will be recorded from the medical record including BMI, height, weight (kg), parity, age and gestational age. The ISS device is a customized commercial frequency domain oximeter (Imagent, ISS Inc.; http://www.iss.com/biomedical/instruments/imagent.html) with multiple laser sources and multiple detectors. This instrument is safe, uses non-ionizing radiation. The Raydiant Oximetry Sensing System (ROSS) device is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy. The combination of these two devices makes up the Raydiant Oximetry GEN 3 device. This GEN 3 device will be positioned on the maternal abdomen of women volunteers in the late 3rd trimester. This sensor will measure light scattering and absorption for a period of about 10-20 minutes. A second measurement may be obtained for an additional site on the maternal abdomen. The Sponsor anticipates this study will require about 6-12 months to enroll all study subjects at all study sites, and another month to complete primary analyses.
Distancing is an emotion regulation skill that relies in part on self-projection, or the ability to shift perspective from the here and now to a simulated time, place, or person. Based on prior review and meta-analysis of the distancing literature, a new model has been developed of the neurocognitive processes that support distancing. The proposed experiment will test the model causally through a neural intervention that should impair or enhance the ability of healthy adults to successfully apply distancing to down-regulate negative affect. In the model, it is hypothesized that the temporoparietal junction (TPJ) was a key region mediating the self-projection aspect of distancing. Leveraging recent functional magnetic resonance imaging (fMRI) work, the experiment will functionally modulate this region through inhibitory transcranial magnetic stimulation (TMS) to test its causal role in distancing. Importantly, the proposed work shifts emphasis from traditional models of emotion regulation, which implicate frontal executive control mechanisms, to new cognitive processes and brain targets that can ultimately lead to novel approaches to treat affective disorders.
BACKGROUND: Patients with head and neck cancer often experience impaired sleep. Moreover, the treatment may negatively affect sleep quality. The aim of this observational study was to evaluate the sleep quality after treatment for head and neck cancer, and its relationship with quality of life and psychological distress.
METHODS: A total of 151 patients who underwent treatment for head and neck cancer at our department were included in the study. Quality of life, sleep quality, risk of sleep apnea, sleepiness, pain, and psychological distress were assessed by means of specific questionnaires.
RESULTS: The median follow-up was 30 months. Poor sleep quality was observed in 55.6% of the cases. An association between PSQI global sleep quality and EORTC global health status was found. The DT, HADS anxiety, and HADS depression scores were associated to PSQI global score, sleep quality, sleep latency, sleep disturbances, and daytime dysfunction.
CONCLUSIONS: Sleep disturbances, particularly OSA and insomnia, are frequent in HNC patients, and significantly impact their quality of life and psychological well-being. Given the effect of sleep on overall well-being, addressing sleep disorders should be a priority in the care of HNC patients.
In this arm of the study, participants will receive nebulized Salbutamol, a bronchodilator commonly used in the management of bronchospasm associated with respiratory conditions, including bronchiolitis. The objective is to evaluate the effectiveness of Salbutamol in comparison to 3% hypertonic saline in improving the clinical outcomes of infants with bronchiolitis.