anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A patient management system includes a device, an interactive display, a repeater unit, and a host. The device assesses at least one dietary condition of a patient. The interactive display receives patient input related to the patient's dietary conditions and communicates dietary feedback to the patient. The system may also include at least one sensor configured to assess at least one dietary condition of the patient. The repeater unit collects information from the device, the interactive display and the sensors. The host communicates with the repeater through a network. The patient's own input of dietary information into the system can be useful for verifying sources of measured data and enhancing feedback given to the patient. The system is configured to perform accurately even in the absence of patient input or the input of incorrect information by the patient.
Liugan Shuangjie Heji, take orally, 4 times a day, 100 ml each time (i.e. two doses per day), for a course of five days.
AIMS: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment. AD pathology involves protein acetylation. Previous studies have mainly focused on histone acetylation in AD, however, the roles of nonhistone acetylation in AD are less explored.
METHODS: The protein acetylation and expression levels were detected by western blotting and co-immunoprecipitation. The stoichiometry of acetylation was measured by home-made and site-specific antibodies against acetylated-CaM (Ac-CaM) at K22, K95, and K116. Hippocampus-dependent learning and memory were evaluated by using the Morris water maze, novel object recognition, and contextual fear conditioning tests.
RESULTS: We showed that calmodulin (CaM) acetylation is reduced in plasma of AD patients and mice. CaM acetylation and its target Ca2+ /CaM-dependent kinase II α (CaMKIIα) activity were severely impaired in AD mouse brain. The stoichiometry showed that Ac-K22, K95-CaM acetylation were decreased in AD patients and mice. Moreover, we screened and identified that lysine deacetylase 9 (HDAC9) was the main deacetylase for CaM. In addition, HDAC9 inhibition increased CaM acetylation and CaMKIIα activity, and hippocampus-dependent memory in AD mice.
CONCLUSIONS: HDAC9-mediated CaM deacetylation induces memory impairment in AD, HDAC9, or CaM acetylation may become potential therapeutic targets for AD.
Total intravenous anesthesia (TIVA) is a common anesthesia method used today as an alternative to inhalation anesthesia. Loss of consciousness is two important components of general anesthesia, in order to give the patient safe analgesia and not to remember any adverse events related to the operation. While the depth of anesthesia can be controlled by monitoring the minimum alveolar concentration (MAK) in the ventilator devices in the operating room we use modernly, there was no more objective method than measuring the plasma level of drugs in intravenous anesthesia. The schemes created by the anesthetists according to plasma drug levels were used when administering total intravenous anesthesia. Target Controlled Anesthesia (TCI) devices, on the other hand, are pumps that have been used more frequently recently and that can deliver the required blood concentration of a drug in bolus and infusion form according to pharmacokinetics models calculated with personal data. In TCI anesthesia, intravenous infusion of anesthetics provides a more stable drug concentration in the plasma and at the site of action compared to repeated bolus techniques. Thus, it is ensured that the drug remains in the therapeutic range, avoiding the consequences such as over- or under-administration of the drugs. The subject of the study is to determine which of the 2 routinely used methods in rhinoplasty operations affects respiratory functions less.
Patients receive lutetium Lu 177 dotatate IV over 30 minutes. Cycles repeat Q6W for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive gallium Ga 68-dotatate IV during screening then undergo PET/CT scan at baseline and collection of blood throughout the trial.
1. Animal data. Phenobarbital sodium is carcinogenic in mice and rats after lifetime administration. In mice, it produced benign and malignant liver cell tumors. In rats, benign liver cell tumors were observed very late in life. 
  2. Human data. In a 29-year epidemiological study of 9,136 patients who were treated on an anticonvulsant protocol that included phenobarbital, results indicated a higher than normal incidence of hepatic carcinoma. Previously, some of these patients were treated with thorotrast, a drug that is known to produce hepatic carcinomas. Thus, this study did not provide sufficient evidence that phenobarbital sodium is carcinogenic in humans. Data from one retrospective study of 235 children in which the types of barbiturates are not identified suggested an association between exposure to barbiturates prenatally and an increased incidence of brain tumor. (Gold, E., et al., "Increased Risk of Brain Tumors in Children Exposed to Barbiturates," Journal of National Cancer Institute, 61:1031-1034, 1978).
Congenital heart defects (CHD) are among the most common major congenital anomalies with an incidence of about 8-12/1,000 live births worldwide. The mechanism of CHD is still unclear. Many studies indicated that the level of key nutrients (eg.folic acid and vitamins) during peri-conceptional period might affect the incidence of CHD, but the evidence is limited. The study aimed to explore the association between serum key nutrients during peri-conceptional period and the incidence of CHD in newborn. All couples attending pre-pregnancy physical examination from 11 districts (Minhang District, Huangpu District, Xuhui District, Changning District, Jingan District, Putuo District, Yangpu District, Jiading District, Pudong District，Songjiang District, Qingpu District) in Shanghai from March 2016, are recruited and their blood samples and questionnaires about the supplementation of key nutrients are collected. During the gestation, venous blood of pregnant women at all of three trimesters is taken. Besides, questionnaires about the supplementation of key nutrients at the first antenatal visit are also obtained. The level of serum folic acid, vitamin A and vitamin B12 at preconception and during gestation are measured. Finally, investigators identifies those whose newborns developed CHD during follow-up as the cases. Then, investigators selects four controls for each case from the rest of the cohort by matching on constitutional determinants of CHD such as age and sex. Participants are identified by national identification number during the follow up. The level of serum key nutrients is compared in cases and controls. Univariate and multivariate association analyses will be performed to identify risk factors to CHD by using multivariate logistic regression model.
BACKGROUND: Parameters obtained from two-dimensional (2D) cross-sectional images have been used to determine body composition. However, data from three-dimensional (3D) volumetric body images reflect real body composition more accurately and may be better predictors of patient outcomes in cancer. This study aimed to assess the 3D parameters and determine the best predictive factors for patient prognosis.
METHODS: Patients who underwent surgery for colorectal cancer (CRC) between 2010 and 2016 were included in this study. Preoperative computed tomography images were analysed using an automatic segmentation program. Body composition parameters for muscle, muscle adiposity, subcutaneous fat (SF) and abdominal visceral fat (AVF) were assessed using 2D images at the third lumbar (L3) level and 3D images of the abdominal waist (L1-L5). The cut-off points for each parameter were determined using X-tile software. A Cox proportional hazards regression model was used to identify the association between the parameters and the treatment outcomes, and the relative influence of each parameter was compared using a gradient boosting model.
RESULTS: Overall, 499 patients were included in the study. At a median follow-up of 59 months, higher 3D parameters of the abdominal muscles and SF from the abdominal waist were found to be associated with longer overall survival (OS) and disease-free survival (all P < 0.001). Although the 3D parameters of AVF were not related to survival outcomes, patients with a high AVF volume and mass experienced higher rate of postoperative complications than those with low AVF volume (27.4% vs. 18.7%, P = 0.021, for mass; 27.1% vs. 19.0%, P = 0.028, for volume). Low muscle mass and volume (hazard ratio [HR] 1.959, P = 0.016; HR 2.093, P = 0.036, respectively) and low SF mass and volume (HR 1.968, P = 0.008; HR 2.561, P = 0.003, respectively), both in the abdominal waist, were identified as independent prognostic factors for worse OS. Along with muscle mass and volume, SF mass and volume in the abdominal waist were negatively correlated with mortality (all P < 0.001). Both AVF mass and volume in the abdominal waist were positively correlated with postoperative complications (P < 0.05); 3D muscle volume and SF at the abdominal waist were the most influential factors for OS.
CONCLUSIONS: 3D volumetric parameters generated using an automatic segmentation program showed higher correlations with the short- and long-term outcomes of patients with CRC than conventional 2D parameters.
PROBLEM TO BE SOLVED: To obtain an oily cosmetic which gives little greasy touch and feeling of wrongness to skins and is excellent in the wetting effect for preventing skins from drying and its sustainability or the effect for improving chapped skins by including a water-soluble polyhydric alcohol, an oil-soluble monohydric alcohol and a specific glucopyranoside derivative. SOLUTION: This oily cosmetic is obtained by including (A) 0.1-50 wt.% of a water-soluble polyhydric alcohol (e.g. 1,3-butylene glycol, dipropylene glycol or the like), (B) 0.1-50 wt.% of an oil-soluble monohydric alcohol (e.g. a higher aliphatic alcohol or the like such as cetyl alcohol, lauryl alcohol or the like) and (C) 0.01-5 wt.% of a glucopyranoside derivative (e.g. ethyl glucoside, propyl glucoside or the like) of the formula (wherein R is a 2-8C alkyl). The components B and C are preferably blended in proportions of 0.5-10 fold and 0.01-2 fold amounts, respectively, based on the component A, respectively.
Polymers comprising reversible hydrophobic functionalities are disclosed. The preferred embodiment polymers comprise Lewis acid segments and Lewis base segments. The polymer segments are, by themselves, hydrophilic and will either swell or dissolve in water. When the segments are incorporated into a polymer according to the present invention, the segments form water-insoluble or hydrophobic complexes. Upon changes in pH, temperature or solvent type, these complexes may dissociate, giving large transitions in polymer viscosity, emulsification ability, mechanical strength or transport properties. These polymers are useful as reversible emulsifiers which form stable emulsions at acidic pH and unstable emulsions at basic pH, as water-borne thickeners having low viscosity at low pH and high viscosity at high pH, as superabsorbing resins, or as coatings for pharmaceutical or agricultural agents.
Disclosed are the micronized poorly soluble medicine bicyclol, its preparation process and the skeleton slow release formulation of bicyclol for oral administration, as well as the preparation process thereof. Its dissolution rate in-vitro and absorbability in-vivo can be significantly improved after bicyclol gets micronized. By adding the micronized bicyclol as active component to the gel skeleton material, an oral slow release formulation of high bioavailability is obtained. The micronized bicyclol together with the mixture of slow release material and blocking agent can be made into skeleton slow release tablets, slow release micropills and the like. Alternatively, it’s possible to incorporated both the slow release and the immediate release components into bilayer tablets, core tablets, or to make them into micropills individually and then pack into hard capsules. This formulation has a more stable blood drug level, and is more beneficial to the treatment against chronic hepatitis of type B and the display of its antiviral action.
OBJECTIVE: To investigate the prevalence and risk factors of psychological symptoms and quality of life (QoL) in early patients with inflammatory bowel disease (IBD).
METHODS: From September 2021 to May 2022, a unified questionnaire was developed to collect clinical data from early patients with IBD from 42 tertiary care hospitals. The influencing factors of psychological symptoms and poor QoL are screened by logistic regression analysis for constructing model in predicting poor QoL. The consistency index, receiver operating characteristic (ROC) curve, area under the ROC curve (AUC), net reclassification improvement (NRI), integrated discrimination improvement (IDI), calibration curve, and decision curve analysis (DCA) were used to evaluate the performance of the model.
RESULTS: A total of 939 early patients with IBD were surveyed, Among them, 20.3% exhibited anxiety, 21.7% had depression, 57.3% experienced sleep disturbance, and 41.9% reported poor QoL. The factors influencing psychological symptoms varied between ulcerative colitis (UC) and Crohn's disease (CD) patients. The QoL was primarily affected by disease activity, income level and depression. The AUC value of the model in the training group was 0.781 (95% CI: 0.748-0.814). The calibration diagram of the model closely matched the ideal curve. Compared to other prediction models, our model showed superior predictive capability, with NRI and IDI values of 0.324 (95%CI:0.196-0.4513) and 0.026 (95%CI:0.014-0.038), respectively. DCA indicated that the nomogram model could provide clinical benefits.
CONCLUSION: Early patients with IBD exhibit a high prevalence of psychological symptoms and poor QoL. The nomogram prediction model we constructed demonstrates high accuracy and performance in predicting QoL in early patients with IBD.
FIELD: chemistry.SUBSTANCE: invention relates to a new simple ether of formula (I), which can be used as an additive to detergents and cleaning agents used, for example, for washing fabrics at low temperatures. In formula (I)Formula (I), R=H or ethyl, k=0 or 1, A is a linear or branched alkylene group having C-Ccarbon atoms, A may be the same or different from each other, at least one A represents a linear or branched C-alkylene group, the sum of x, y and z is in the range from 5 to 10, x≥1, y≥1 and z≥1, Z=NH. Such etheramines are preferred, where at least three A are linear or branched C-alkylene group, especially compounds where all A groups are linear or branched C-alkylene group. Further, the process for preparing the ether of formula (I) comprises the steps a) interaction of glycerine or 1,1,1-trimethylolpropane with C-alkylene oxide and optionally with C-Calkylene oxide, where the molar ratio of glycerol or 1,1,1-trimethylolpropane and C-alkylene oxide is in the range from 1:3 to 1:10, and b) aminating the alkoxylated glycerine or alkoxylated 1,1,1-trimethylolpropane with ammonia. While the preferable molar ratio of glycerine or 1,1,1-trimethylolpropane and C-alkylene oxide is in the range from 1:3 to 1:6, and the alkylene oxide is ethylene oxide, propylene oxide, or a mixture thereof. Amination is carried out in the presence of a catalyst containing copper, nickel or cobalt. While the catalytically active substance in the catalyst before its reduction with hydrogen contains oxygen-containing compounds of aluminum, copper, nickel and cobalt and possibly a compound of tin in an amount of from 0.2 to 5.0 wt.% of oxygen-containing compounds in terms of SnO. This method allows to obtain ethers with a degree of amination of 95.66–99.31 %.EFFECT: proposed compounds, when added to known detergents, significantly increase the effectiveness of the detergent when washing, for example, cotton jersey with grease and oil stains.8 cl, 7 tbl, 5 ex
In addition to standard care, participants randomized to the intervention arm will also receive the CardioPrevent® Program. This is a 1-year, evidence-based behaviour change lifestyle program that consists of 25 contacts (in person, by phone and in groups) with a trained lifestyle counsellor to facilitate desired lifestyle behaviours within the participants' own social context. Participants in both arms will receive educational material about the risk of CVD, and CVD prevention for women with HDP from the Preeclampsia Foundation.
Cochlear implants (CIs) provide a solution for individuals with severe sensorineural hearing loss to regain their hearing abilities. When someone experiences this form of hearing impairment in both ears, they may be equipped with two separate CI devices, which will typically further improve the CI benefits. This spatial hearing is particularly crucial when tackling the challenge of understanding speech in noisy environments, a common issue CI users face. Currently, extensive research is dedicated to developing algorithms that can autonomously filter out undesired background noises from desired speech signals. At present, some research focuses on achieving end-to-end denoising, either as an integral component of the initial CI signal processing or by fully integrating the denoising process into the CI sound coding strategy. This work is presented in the context of bilateral CI (BiCI) systems, where we propose a deep-learning-based bilateral speech enhancement model that shares information between both hearing sides. Specifically, we connect two monaural end-to-end deep denoising sound coding techniques through intermediary latent fusion layers. These layers amalgamate the latent representations generated by these techniques by multiplying them together, resulting in an enhanced ability to reduce noise and improve learning generalization. The objective instrumental results demonstrate that the proposed fused BiCI sound coding strategy achieves higher interaural coherence, superior noise reduction, and enhanced predicted speech intelligibility scores compared to the baseline methods. Furthermore, our speech-in-noise intelligibility results in BiCI users reveal that the deep denoising sound coding strategy can attain scores similar to those achieved in quiet conditions.
The invention relates to a hair care and scalp moistening shampoo and its preparation method. The shampoo is prepared from the following raw materials, by weight, 5-15 parts of Germany pearl concentrate, 3-10 parts of cortex dictamni, 2-8 parts of Adenosma glutinosum (Linn.) Druce, 4-9 parts of Spora Lygodii, 5-10 parts of cassia seed, 0.1-0.3 parts of pumpkin seed essential oil, 0.2-0.4 parts of peach seed essential oil and 100-600 parts of water. The shampoo can care hair, makes hair easy to wash, soft and bright, and can moisten scalp. The preparation method comprises the following steps: crushing cortex dictamni, Adenosma glutinosum (Linn.) Druce, Spora Lygodii and cassia seed, adding water 2 times the amount of the above obtained powder, boiling with strong fire for 5min, boiling with slow fire for 10min, filtering, taking the obtained filtrate, cooling to 30DEG C, adding the Germany pearl concentrate, stirring for 3min, adding water, the pumpkin seed essential oil and the peach seed essential oil, uniformly stirring to form a dew, and bottling. The method is simple and suitable, and is easy to operate.
Days 22 to 42: After a 21 day period, the participants from Placebo + Formoterol (Sequential) Arm the will be dosed for 21 days with a combination of placebo revefenacin and formoterol administered as a combined solution. Formoterol will be administered again in the evening.
Patients in this arm also receive a combination of Durvalumab and Tremelimumab. Similar to Cohorte 1B, they receive Tremelimumab as a single dose of 300 mg IV, followed by Durvalumab administered at a dose of 1500 mg IV every 4 weeks. However, patients in this arm have tumors with microsatellite stability (MSS), unlike Cohorte 1B where patients have tumors with microsatellite instability (MSI). This arm aims to evaluate the efficacy and safety of the Durvalumab and Tremelimumab combination in patients with MSS tumors.
Levosimendan administered as a continuous infusion over a 24-hour period at the rate of 0.2μg/kg/min, with no bolus administration. The infusion will begin 24H to 48H before anesthetic induction.
Participants will receive intraperitoneal docetaxel combined with the standard of care. A standard 3 + 3 dose escalation design will be used according to the dose escalation plan.
BACKGROUND: Naoxueshu oral liquid is the only approved drug for acute treatment of cerebral hemorrhage in China. It has been used widely for the treatment of acute ischemic stroke and acute hemorrhagic stroke. However, safety and efficacy data on the early use of Naoxueshu oral liquid are lacking. The main purpose of this study is to observe the benefit and safety of early use of Naoxueshu oral liquid (< 72 h of cerebral hemorrhage) and offer evidence into the potential superiority of Naoxueshu oral liquid in patients with hemorrhagic stroke, and its healthcare costs.
METHODS: This registration study for the prevention and treatment of cerebral hemorrhage using Naoxueshu oral liquid will be a quantitative, prospective, multicenter, observational clinical registry study. We aim to register 2000 patients with cerebral hemorrhage within 7 days of disease onset. This study will be an observational study and not interfere with the medication regimen of participants. Hence, we will not allocate patients. The main observation indicators will be the hematoma volume and the proportion of reduction 14 days post-cerebral hemorrhage (or at hospital discharge), onset of new stroke (ischemic stroke, hemorrhagic stroke) within 12 months of disease onset, independence in everyday life activities (modified Rankin Scale score ≤ 2), total cost during hospitalization, and treatment costs.
CONCLUSION: This registration study will offer strong evidence for the efficacy and safety of Naoxueshu oral liquid for the prevention and treatment of cerebral hemorrhage, particularly with regard to early use (72 h after onset). It will offer evidence into the potential advantages of Naoxueshu oral liquid in patients with hemorrhagic stroke, including healthcare costs.
The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated secretory phenotype (SASP), which may regulate tumorigenesis. Senolytic therapy is considered a novel anticancer strategy that eliminates the deleterious effects of senescent cells in the TME. Here, we show that two different types of senolytic drugs, despite efficiently depleting senescent cells, have opposite effects on cancer-associated fibroblasts (CAFs) and their ability to regulate epithelial-mesenchymal transition (EMT). We found that senolytic drugs, navitoclax and the combination of dasatinib/quercetin, reduced the number of spontaneously senescent and TNF-induced senescent CAFs. Despite the depletion of senescent cells, the combination of dasatinib/quercetin versus navitoclax increased the secretion of the SASP pro-inflammatory cytokine IL-6. This differential effect correlated with the promotion of enhanced migration and EMT in MC38 colorectal cancer cells. Our results demonstrate that some senolytics may have side effects unrelated to their senolytic activity and may promote tumorigenesis. We argue for more careful and extensive studies of the effects of senolytics on various aspects of tumor progression and tumor resistance to therapy before the senolytic strategy is implemented in the clinic.
This group received treatment with lingual brackets with 0.018-inch slots (DTC Orthodontics, Hangzhou, China) applied with the aid of a special, indirect bonding technique, the "Modified HIRO® Technique." Individual lingual archwires (Forestadent®, Germany) were also used.