anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Excessive opioid prescribing following surgery contributes to the growing opioid crisis. Prescribing practices are modifiable, yet data to guide appropriate prescription of opioids at surgical discharge remain sparse. This study aimed to evaluate factors associated with opioid consumption following discharge from surgery.
METHODS: An international prospective multicentre cohort study was performed recruiting adult patients undergoing common general, orthopaedic, gynaecological and urological surgery, with follow-up 7 days after discharge. The primary outcome measures were the quantities of prescribed and consumed opioids in oral morphine milligram equivalents. Descriptive and multivariable analyses were performed to investigate factors associated with the primary outcome measures.
RESULTS: This analysis included 4273 patients from 144 hospitals in 25 countries. Overall, 1311 (30.7%) patients were prescribed opioids at discharge. For those patients prescribed opioids, mean (SD) 179 (240) oral morphine milligram equivalents were prescribed, yet only 81 (145) oral morphine milligram equivalents were consumed within the first 7 days after discharge. An increased dose of opioids prescribed at discharge was associated with an increased dose of opioids consumed during the follow-up period (β = 0.33 (95%CI 0.31-0.34), p < 0.001). The risk of prescribing more opioids than patients consumed increased as quantities of opioids prescribed at discharge exceeded 100 oral morphine milligram equivalents, independent of patient comorbidity, procedure and pain. Patients were prescribed more than twice the quantity of opioids they consumed in the first 7 days following discharge from surgery.
CONCLUSIONS: Our data suggest that the current quantities of opioids provided at discharge exceed patient needs and may contribute to increasing community opioid use and circulation.
Neonatal adrenal haemorrhage affects approximately 0.17%-0.21% of babies, although, usually, it remains asymptomatic, and therefore, the exact incidence is probably greater. The increased vascularity and relatively large size of the adrenal glands in neonates increases their vulnerability to haemorrhage during labour. There have been few cases that have presented with bowel obstruction.A term neonate was admitted with bilious vomiting, dehydration and mottled skin. He was afebrile but hypoglycaemic. Dark green aspirations were present on placement of a nasogastric tube, and emergent upper gastrointestinal contrast study demonstrated failure of contrast to pass and deviation of the duodenum. Together these features raised concern of malrotation with volvulus promoting surgical exploration. Intraoperatively, a left suprarenal mass was discovered, causing bowel obstruction. An ileostomy was created, and a biopsy was taken. Adrenal haemorrhage was diagnosed, which is an extremely rare cause of bowel obstruction. Serial ultrasound scans have been done since, showing reduction of the haemorrhage and his ileostomy has been reversed.Adrenal haemorrhage is rarely reported to cause bowel obstruction. A neonate with bilious vomiting and an abnormal contrast may represent malrotation; however, adrenal haemorrhage is an uncommon, but important, differential to consider in these scenarios.
According to randomization, the patients in the reiki/sham reiki group were taken to a quiet single room and reiki/sham reiki was applied for approximately 25-30 minutes. will be applied. Reiki application will be applied by a researcher who has Reiki I and Reiki II level training.
Subjects ingest placebo (glycerin) daily beginning with a dose of 0.000165 mcg, followed by a build-up phase (escalating placebo doses every 2 weeks, achieving a maintenance dose by 36 weeks). Thereafter, subjects are on a maximally tolerated maintenance dose (165 mcg to 1,386 mcg) for \>= 8 weeks. After Week 44, subjects are given a 5,000 mg Oral Food Challenge (OFC) using peanut powder. Subjects/study staff are unblinded following this OFC and subjects no longer receive placebo dosing but are crossed over and receive open label high dose peanut SLIT; the study procedures and schedule are the same as for the Low Dose Peanut SLIT group, the only difference is the maximum maintenance dose is almost 3-fold higher at 3,696 mcg/day. DB=Double Blind, SLIT=Sublingual Immunotherapy, OL=Open Label.
Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1. Patients may also receive bevacizumab IV over 90 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Parents in the iPEACE condition will receive an 8-week text-messaging intervention to build skills in mental health literacy and self-efficacy. Texts will be delivered several days per week over an 8-week period. The intervention is fully automated.
We prospectively and consecutively enrolled 75 patients suffering from a SAH (n=44) or a NSAH (n=31). Inclusion criteria were patients aged between 18 and 75 years with an acute hepatitis defined by an abrupt rise in serum aminotransaminase levels during the 15 previous days (AST or ALT greater than 500 IU/L or greater than 10 times the upper normal value); the acute hepatitis was considered as severe if the prothrombin index was lower than 50% and as non-severe if it was greater than 50%. We excluded patients with the following conditions: a history of hypothalamic-pituitary or adrenal disease, corticosteroids treatment within the previous 6 months, ketoconazole intake, oral candida infection, any visible bleeding in the oral cavity, liver transplanted patients, acute alcoholic hepatitis and night workers. Twenty-nine healthy controls (HC) were thereafter enrolled and similarly distributed with the SAH group on age, sex and estrogen pill intake, estrogen therapy being the most common cause for changes in CBG levels. HC were without any known illnesses and were not receiving any medications. To evaluate the range of the SFC concentrations, eight patients with a known AD caused by impairment of hypothalamic-pituitary-adrenal axis (n=5) and adrenal gland (n=3) and followed at the Endocrinology Department of Besancon were also studied.

STC, SFC and salivary cortisol concentrations were measured blindly before (T0 between 8am and 9am) and 60 minutes after (T60) an intravenous injection of 250 µg tetracosactrin (synacthenÒ, Sigma-Tau laboratory, France). Serum CBG, albumin and ACTH were also measured
PURPOSE:To provide an antitumor agent exhibiting cytocidal activity against cancer cells in vitro, by using 1,25-dihydroxycholecalciferol as an active component. CONSTITUTION:1,25-Dihydroxycholecalciferol of formula is used as an active component. The compound exhibits proliferation inhibiting effect and cytocidal effect in vitro to tumor cells such as K-562 cell derived from human leukemia, LICR-LON-HMy2 cell derived from human myeloma, etc. Furthermore, an antitumor effect can be observed by the test conducted by using mouse and rat as the host. Dose: 0.1-10,000mug, preferably 0.5-1,000mug daily for adult by parenteral or oral administration. The compound of formula is preferably 1alpha,25-dihydroxycholecalciferol.
The present application relates to the technical field of artificial intelligence. Provided are a health scheme recommendation method and apparatus based on deep learning, and a device and a medium. The method comprises: acquiring an initial similarity between an initial tongue image and a standard tongue image; extracting an initial tongue coating image and an initial tongue nature image from the initial tongue image, and inputting same into a preset tongue coating checking model and a preset tongue nature checking model, so as to obtain a tongue coating state and a tongue nature state; determining tongue association information, and thereby determining a plurality of health schemes to be selected; and determining a mental state of a user, so as to determine a recommended health scheme from among the health schemes to be selected. Further provided in the present application are a health scheme recommendation apparatus based on deep learning, and a device and a medium. A tongue nature state and a tongue coating state are obtained by means of a preset tongue coating checking model and a preset tongue nature checking model, and a suitable health scheme is recommended by combining two factors, i.e. a physical health condition and a mental state of a user, such that consideration dimensions are more comprehensive, thereby improving the user satisfaction degree. The present application is simple and feasible.
The invention relates to a use of progesterone in preparation of a drug for treating and recovering infant encephalopathy. The drug containing progesterone can be processed into an intravenous injection, a muscle injection or a subdermal implant by different methods and is used for treating anomaly encephalopathy such as hypoxic-ischemic brain damages, cerebral palsy and epilepsia caused by infant birth injuries or extruded cerebral trauma. The use of progesterone in preparation of a drug for treating and recovering infant encephalopathy is a novel use. The invention also provides the dosage forms, administration methods and dosages of the drug containing progesterone. Progesterone is safe and non-toxic, has obvious pharmacological effects, greatly reduces a mortality rate of babies having birth injuries, and reduces and even prevents cerebral palsy and disability caused by injuries. Therefore, the progesterone has a great clinical application meaning.
An efficient and stable anionic polysaccharide calcium phosphate nanoparticle, and its preparation method and application are provided. The invention belongs to the groupThe field of transfection reagents and preparation thereof. In order to overcome the defects of a calcium phosphate non-viral gene vector, the invention designs and constructs a high-efficiency stable anionic polysaccharide calcium phosphate nanoparticle modified by diphosphonate and glycosaminoglycan. The anionic polysaccharide calcium phosphate nanoparticles are composed of calcium phosphate, bisphosphonate and glycosaminoglycan. The method comprises the following steps: s1: preparing a calcium phosphate nanoparticle solution; s2: adding biphosphonate solution dropwise into calcium phosphate nanoparticle solution, stirring, adding glycosaminoglycan solution dropwise, stirring, high-speed centrifuging after reaction, and adding ddH  2  And (O) repeatedly washing. The anionic polysaccharide calcium phosphate nanoparticles are used for preparing in-vivo and in-vitro transfection reagents of DNA and RNA. The transfection reagents are used to deliver deoxyribonucleic acid, plasmid DNA, ribonucleic acid, or functional proteins.
The invention relates to the technical field of microneedles, in particular to a Cu based on chitosan  2‑x  Se micro needle and preparation method thereof, including synthesizing Cu  2‑x  Se and Cu preparation  2‑x  Se-chitosan micropins. Cu of chitosan disclosed by the invention  2‑x  Se micro needle is a patch loaded with biocompatible nano enzyme, the nano enzyme is composed of microelements selenium and copper required by human body, PVP is used for assisting water precipitation method to prepare Cu  2‑   x  Se nanocrystals. Then, cu is added  2‑x  Se nanocrystalline is dissolved in chitosan matrix to prepare nano enzyme microneedle patch, and the nano enzyme microneedle patch is inserted into residual tumor. The patch can keep the continuous action for more than 10 days in the operation wound, and the microneedle can greatly reduce the recurrence rate of the residual tumor model and inhibit the growth of the re-inoculated tumor. The microneedles also have superior biocompatibility. The method provides a simple and effective preparation for convenient and safe tumor vaccination.
PURPOSE: A method for producing a snapping turtle extract using germanium-containing water and Chinese herbal medicines is provided. Whereby, the extract has effects on improving physical constitution, prevents aging of human skin and reducing stress. CONSTITUTION: A snapping turtle is washed with underground water disposed at a depth of 120m below the ground level containing germanium, mixed with Chinese herbal medicines containing Paeonia lactiflora Pall., Atractylodes macrocephala Koidz., Glycyrrhiza uralensis Fisch., Ligusticum chuanxiong Hort., Pueraria thunbergiana(Sieb. et Zucc.) Benth., Rehmanniae glutinosa Liboschitz, Pleuropterus multiflorus Turcz. and Zizyphus jujuba Mill var. inermis Rehder, aged for 240hr, extracted for 6hr or more and sterilized at 95deg.C or more for 1hr in the first stage. Thereafter, the extract is packed and sterilized at 90deg.C for 20min in the second stage.
Since many years the use of infant formulae manufactured from hydrolysed proteins are recommended for infants at risk for developing allergies if they cannot be exclusively breast-fed. Although the use of such formulae manufactured from hydrolysed protein is legally authorized according to the respective legal framework since many years (currently: Directive 2006/141/EC), the safety of each hydrolysed protein has to be substantiated by additional clinical data according to new legal requirements (Del. Regulation (EU) 2016/127). This study is intended to generate clinical safety data: demonstrating adequate growth of infants fed a formula manufactured from hydrolysed protein in comparison to infants fed a formula manufactured from intact protein. As formula manufactured from hydrolyzed proteins is known to have beneficial effects on gastrointestinal comfort, it is also fed to infants not at risk for developing allergies. Therefore, this study additionally investigates the impact of hydrolysed protein on gastrointestinal tolerance.
Periodontitis is a complex disease characterized by distinct inflammatory stages, with a peak of inflammation in the early phase and less prominent inflammation in the advanced phase. The insulin-like growth factor 2-binding proteins 2 (IGF2BP2) has recently been identified as a new m6A reader that protects m6A-modified messenger RNAs (mRNAs) from decay, thus participating in multiple biological processes. However, its role in periodontitis remains unexplored. Here, we investigated the role of IGF2BP2 in inflammation and osteoclast differentiation using a ligature-induced periodontitis model. Our findings revealed that IGF2BP2 responded to bacterial-induced inflammatory stimuli and exhibited differential expression patterns in early and advanced periodontitis stages, suggesting its dual role in regulating this disease. Depletion of Igf2bp2 contributed to increased release of inflammatory cytokines, thereby exacerbating periodontitis after 3 d of ligature while suppressing osteoclast differentiation and ameliorating periodontitis after 14 d of ligature. Mechanistically, we demonstrated that IGF2BP2 directly interacted with Cd5l and Cd36 mRNA via RNA immunoprecipitation assay. Overexpression of CD36 or recombinant CD5L rescued the osteoclast differentiation ability of Igf2bp2-null cells upon lipopolysaccharide stimulus, and thus the downregulation of Cd36 and Cd5l effectively reversed periodontitis in the advanced stage. Altogether, this study deepens our understanding of the potential mechanistic link among the dysregulated m6A reader IGF2BP2, immunomodulation, and osteoclastogenesis during different stages of periodontitis.
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive 100 mg MDMA.
Other short-acting sympathomimetic aerosol bronchodilators or epinephrine should be used with caution with XOPENEX HFA Inhalation Aerosol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects. 

  1. Beta-blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-adrenergic agonists, such as XOPENEX HFA Inhalation Aerosol, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers should be considered, although they should be administered with caution. 
  2. Diuretics: The ECG changes and/or hypokalemia that may result from the administration of non–potassium-sparing diuretics (such as loop and thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with non–potassium-sparing diuretics. 
  3. Digoxin: Mean decreases of 16% to 22% in serum digoxin levels were demonstrated after single-dose intravenous and oral administration of racemic albuterol, respectively, to normal volunteers who had received digoxin for 10 days. The clinical significance of these findings for patients with obstructive airway disease who are receiving XOPENEX HFA Inhalation Aerosol and digoxin on a chronic basis is unclear. Nevertheless, it would be prudent to carefully evaluate the serum digoxin levels in patients who are currently receiving digoxin and XOPENEX HFA Inhalation Aerosol. 
  4. Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: XOPENEX HFA Inhalation Aerosol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of albuterol on the vascular system may be potentiated.
PURPOSE:To diagnose easily and quickly the mastitis by detecting immunologically the lactoferrin in the lac. CONSTITUTION:The IgG fraction of the antiserum obtd. by treating the lactoferrin isolated and refined from the colostrum or the whey of the mastitis milk with the perfect adjuvant of Freund and immunizing the same several times with a mammal (rabbit, cattle, hog, etc.) is mainly used for the antibody to be used for diagnosis, and the IgM fraction is also used. The fraction having such antibody activity is adsorbed to latex particles having 0.1-1.0mu grain size to prepare the latex liquid sensitized with the antilactoferrin antibody. Such liquid is used as a diagonosing reagent. A dye agent such as bromophenol blue, malachite green, etc. is added at 0.001-5.0% thereto to permit easy checking of the clot formed by the antigen-antibody reaction.
PURPOSE:To obtain a new compound useful as a phospholipase A2 inhibitor, an antiinflammatory agent or an antipancreatitic agent. CONSTITUTION:This compound is expressed by formula I (X is trifluoromethyl or halogen; R is hydrocarbon or heterocyclic ring), e.g. N-[4,5-bis(trifluoromethyl)-2-pyridyl]--ethanesulfonamide. The compound expressed by formula I is obtained by reacting a compound expressed by formula II (Hal is halogen) with a compound expressed by the formula H2N-SO2R in the presence of a base (e.g. anhydrous potassium carbonate) in a solvent (e.g. dimethylsulfoxide) at 80-150 deg.C for 1-10hr. The compound is useful for treating diseases such as inflammatory, nasal and bronchial airway disorder symptoms, immediate hypersensitive reaction or pancreatitis related to phospholipase A2. In formulating a pharmaceutical preparation, the compound expressed by formula I is contained in an amount of 1-95wt.% and the daily dose for an adult is 0.01-10g.
The diagnostic agent can be injected intravenously and contains a fragment, which is labelled with a gamma- or positron-emitter, of human plasminogen, e.g. <123>I-neoplasmin. The radiolabelled plasminogen fragment which has been introduced into the veins collects at the site of a thrombus so that an increased radioactive emission occurs there and can be detected by one of the known techniques of nuclear medicine only 15 to 30 minutes after injection of the diagnostic agent. To prepare the diagnostic agent, human plasminogen is cleaved with elastase, and neoplasminogen is obtained from the reaction mixture and is then labelled with a radioactive halogen or metal ion so that a chemical bond between the radioactive atom and free tyrosine groups or amino groups of the neoplasminogen is produced. Only about 15 minutes before the intravenous injection is the labelled neoplasminogen biologically activated by addition of urokinase, and thus the formation of radiolabelled neoplasmin initiated. This diagnostic agent not only makes rapid, non-invasive and relatively accurate diagnosis of a thrombosis possible, but also achieves avoidance of unpredicted side effects during the subsequent breakdown in the human body.
Previous studies have reported that oxytocin administration intranasally and orally (spray on the tongue) can modulate neural and behavioral responses during processing of face emotions and can influence top-down attention to social stimuli. However, no research has directly compared the neural and behavioral effects of the two different administration routes on the processing of emotional scenes. In the current randomized, double-blind, between-subjects, placebo-controlled study, 160 healthy male subjects will be recruited and receive treatment either oxytocin (24IU, orally/intranasally) or placebo (orally/intranasally). Prior to treatment, all subjects will complete a number of questionnaires to control for potential group differences in potential confounders in terms of personality traits and mood, including: Beck Depression Inventory-II (BDI), Autism Spectrum Quotient (ASQ), Liebowitz Social Anxiety Scale (LSAS), State-Trait Anxiety Inventory (STAI), Childhood Trauma Questionnaire (CTQ), Interpersonal Reactivity Index (IRI). Additionally, the Positive and Negative Affect Schedule (PANAS) is administered before the treatment and before and after completing the implicit emotional scanning task to measure any changes in mood. Forty-five minutes after receiving treatment, subjects will be required to undergo and MRI scanning session including structural scans and resting-state fMRI followed by an implicit emotional scene processing task (picture source: Nencki affective picture system, including positive, neutral, and negative-valence social and non-social scenes). After fMRI scanning, subjects will be required to rate emotional stimuli presented during the scan on valence, intensity, and arousal using 1-9 point Self-Assessment Manikin (SAM) scales.
BACKGROUND: The recurrence rate of Oral squamous cell carcinoma is between 26.5% and 56.3% of cases. The majority of handling failures are confined & local-regional. However, there is debate regarding the best course of action for these patients with recurring oral Malignancy. The objective of the study was to assess the efficacy of the flap in the reconstruction of oral cancer patients and the complications that can result from it.
METHODS: The study was conducted in Zia-Uddin Hospital, Karachi, Pakistan from 2020 to 2022. Forty patients of recurrent oral cancer, who underwent salvage surgery with a pectoralis major myocutaneous flap were included in the study. Information was taken from the case notes, & the clinical follow-up of the patients were done between one month and one year.
RESULTS: The surgery had an 80% overall success rate. Twenty patients (57.1%) experienced difficulties, including 17 (48.6%) who had flap-related issues. Seven patients (20%) experienced problems unrelated to the flap, such as temporomandibular joint pain and haemorrhage of the chest incision. 9 patients (25.7%) experienced major difficulties, compared to 8 patients (22.9%) who experienced minor complications.
CONCLUSIONS: For the dependable restoration of significant soft tissue abnormalities brought on by the excision of recurrent oral cancer, the pectoralis major myocutaneous flap was found to be a good option. The main issues were related to the reconstruction site. Salvage surgery helps a lot of patients, and some of them can live for two to four years after the procedure.