anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study compares whether or not a safety difference exists between delivering antibiotics via the IV push or IV piggyback method. It will be a single center, prospective, double-blinded, double-dummy, randomized controlled trial on a convenience sample of patients presenting to the ED receiving select beta-lactam antibiotics. Patients will be randomized to IV push antibiotic plus IV piggyback placebo or IV push placebo plus IV piggyback antibiotic. Patients will only be enrolled when a pharmacist who is familiar with the study is available to prepare medications. Treatment group assignment will be predetermined using an Excel random number generator. An investigator will conduct an informed consent with the patient. Only the pharmacist will have access to the randomization records and will not reveal the randomization until the end of the study. If the patient consents to the study, a pharmacist involved in the study will prepare the IV push syringe and IV piggyback. The IV push syringe and IV piggyback will be prepared in a manner that makes the contents blinded. Preparation of the IV push syringe and IV piggyback are standardized. The syringe and piggyback will be handed to the nurse for administration. The IV push antibiotic will be administered over 2-3 minutes and the IV piggyback antibiotic will be administered over 30 minutes. The IV push and IV piggyback will be administered at the same time. A research assistant will conduct surveys with the patient at the start of administration and every 15 minutes for a total of 90 minutes to observe for any adverse drug reactions. During the 90-minute observation period, other medications will be allowed to be administered to the patient. All medications received during this time period will be documented in the patient data sheet. If an adverse drug reaction occurs, the attending physician or medical resident caring for the patient will be notified to come evaluate the patient. Adverse drug reaction severity will be determined by the attending physician or medical resident based on a predetermined scale. Adverse drug reaction information will be collected to determine correlation of adverse drug reaction to drug administration. Adverse drug reactions deemed as serious will be reported to the Institutional Review Board (IRB) within 5 days of the event.
Biologically-active copolymers and compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the T-lymphocyte population. When injected into an animal or human with an antigen, the biologically-active copolymers cause immunosuppression to the antigen. The biologically active copolymers are also useful as growth promoters for animals. Compounds within the biologically-active copolymers of the present invention are effective tumoricidal agents. The biologically-active copolymer of the present invention is a safe and non-toxic formulation that can effectively be administered to animals or humans. The biologically-active copolymer can be mixed in an oil and water emulsion and administered to an animal or human by injection.
Individuals in the deep oscillation group will be treated by the researcher. During the application, individuals will be positioned face down on the stretcher. After the powder is applied to the lumbar region, deep oscillation treatment with a frequency of 80% -100% with a frequency of 145-150 Hz for the first 10 minutes and 55-60 Hz for 5 minutes will be applied with the Physiomed Deep Oscilation device. Each individual will be given a home exercise program (stretching and strengthening for waist, back and abdominal) consisting of stretching and strengthening. Individuals will be asked to come to the center where the research will take place, for a total of six sessions for two weeks, three times a week.
Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure2,3 requires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 15 mcg azithromycin to test the susceptibility of bacteria to azithromycin. The disk diffusion interpretive criteria are provided in Table 3.

A report of “susceptible” indicates that the pathogen is likely to be inhibited if the antimicrobial compound reaches the concentrations usually achievable. A report of “intermediate” indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of “resistant” indicates that the pathogen is not likely to be inhibited if the antimicrobial compound reaches the concentrations usually achievable; other therapy should be selected.
Psoriasis is a chronic, relapsing, inflammatory, multisystem disease characterized by infiltration of inflammatory cells, hyperplasia of epidermal keratinocytes, and abnormal differentiation. Latest data estimate that the prevalence of psoriasis in adults has increased to 11.43%, which shows that the control and treatment of psoriasis is still insufficient. Recent studies showed that traditional Chinese medicine (TCM) is one of the effective methods for the treatment of psoriasis. More and more evidences support the recognition of psoriasis not only affects the skin, but also suffers a chronic multisystem inflammation. Chinese medicine believes that the blood heat is the root of the onset of psoriasis, so the treatment of psoriasis should focus on the method of clearing heat and cooling blood. Therefore, the method of promoting clearing heat and cooling blood. has always been the focus of TCM treatment and prevention of psoriasis. This multicenter, randomized, double-blind, placebo-controlled trial will provide high-quality clinical evidences for evaluating the efficacy, safety and recurrence rate of Jueyin granule, a representative prescription for the treatment of psoriasis with blood heat syndrome, in the treatment of psoriasis.
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need for endoscopic and surgical interventions and in general improved patients' outcomes. A trend towards reduced mortality associated with the use of high-dose intravenous PPI was also observed. Recent clinical trials from Asia have provided evidence that high-dose oral PPIs are associated with a reduction in rebleeding. Current meta-analysis suggests that both high dose (intravenous) and low dose (oral) PPIs effectively reduce rebleeding vs placebo. However, there has been no clinical study to compare IV infusion to oral PPI in this patient population.

Endoscopic stigmata in bleeding peptic ulcers are prognostic and allow risk stratification. Patients with a clean ulcer base have a \< 5% risk of rebleeding; this increases progressively with a flat spot, adherent clot, non-bleeding visible vessel and active bleeding (55%). Early endoscopy in patients with bleeding peptic ulcers selects the high risk ulcers for therapy and evaluation of adjuvant PPI use.
Global chickpea production is restricted by Ascochyta blight caused by the necrotrophic fungi Ascochyta rabiei. Developing locally adapted disease-resistant cultivars is an economically and environmentally sustainable approach to combat this disease. However, the lack of genetic variability in cultivated chickpeas and breeder-friendly markers poses a significant challenge to Ascochyta blight-resistant breeding efforts in chickpeas. In this study, we screened the mini-core germplasm of Cicer reticulatum against a local pathotype of A. rabiei. A modified mini-dome screening approach resulted in the identification of five accessions showing a high level of resistance. The mean disease score of resistant accessions ranged between 1.75 ± 0.3 and 2.88 ± 0.4 compared to susceptible accessions, where the mean disease score ranged between 3.59 ± 0.62 and 8.86 ± 0.14. Genome-wide association study revealed a strong association on chromosome 5, explaining ∼58% of the phenotypic variance. The underlying region contained two candidate genes (Cr_14190.1_v2 and Cr_14189.1_v2), the characterization of which showed the presence of a DNA-binding domain (cl28899 and cd18793) in Cr_14190.1_v2 and its orthologs in C. arietinum, whereas Cr_14190.1_v2 carried an additional N-terminal domain (cl31759). qPCR expression analysis in resistant and susceptible accessions revealed ∼3- and ∼110-fold higher transcript abundance for Cr_14189.1 and Cr_14190.1, respectively.
A system that applies a hair remover to human skin and the hair remover. The system includes a depilatory and an applicator. The depilatory removes hair from the human skin. The applicator applies the depilatory to the human skin. The depilatory is a combination of various all natural ingredients including bees wax, rosin, and natural plant-based oils. The applicator is a brush, rather than a wooden stick as a result of viscosity and properties of the combination of various all natural ingredients of the depilatory versus prior art depilatory waxes.
(See also ADVERSE REACTIONS.)  
Symptoms   
Primarily symptoms of central nervous system depression to the point of somnolence or coma.  
Hypotension and extrapyramidal symptoms.  
Other possible manifestations include agitation and restlessness, convulsions, fever, autonomic reactions such as dry mouth and ileus. EKG changes and cardiac arrhythmias.  
Treatment   
It is important to determine other medications taken by the patient since multiple drug therapy is common in overdosage situations. Treatment is essentially symptomatic and supportive. Early gastric lavage is helpful. Keep patient under observation and maintain an open airway, since involvement of the extrapyramidal mechanism may produce dysphagia and respiratory difficulty in severe overdosage. Do not attempt to induce emesis because a dystonic reaction of the head or neck may develop that could result in aspiration of vomitus. Extrapyramidal symptoms may be treated with anti-parkinsonism drugs, barbiturates, or diphenhydramine hydrochloride. See prescribing information for these products. Care should be taken to avoid increasing respiratory depression.   
If administration of a stimulant is desirable, amphetamine, dextroamphetamine, or caffeine with sodium benzoate is recommended. Stimulants that may cause convulsions (e.g., picrotoxin or pentylenetetrazol) should be avoided.   
If hypotension occurs, the standard measures for managing circulatory shock should be initiated. If it is desirable to administer a vasoconstrictor, norepinephrine and phenylephrine are most suitable. Other pressor agents, including epinephrine, are not recommended because phenothiazine derivatives may reverse the usual elevating action of these agents and cause a further lowering of blood pressure.   
Limited experience indicates that phenothiazines are not dialyzable.
Intervention group will perform physiotherapeutic scoliosis specific exercises for a 60-min period for 2 or 3 times a week under the guidance of experienced physiotherapists with expertise in scoliosis in an outpatient clinic and for a 20-min period per day under the supervision of the parents at home. Physiotherapeutic scoliosis specific exercises consist of patient and family education, 3D self-correction, stabilizing exercises, balance training, breathing exercises, and training in activities of daily living.
Paediatric trigger finger is rare compared to adult trigger finger or paediatric trigger thumb, and the aetiology is unclear. Proposed causes include local trauma, anatomical anomalies and systemic conditions. The aim of the present study was to detail the anatomical causes of surgically treated paediatric trigger fingers and provide an operative algorithm based on the anatomical findings. A total of 76 trigger fingers in 38 patients were identified retrospectively at our institution between 1975 and 2022. In total, 41 fingers in 26 patients had anatomical variations. A nodular thickening on the tendon, similar to Notta's nodule in trigger thumbs, was the most common anatomical cause. Abnormal decussation of the flexor digitorum superficialis tendon was the second most common variation. The recurrence rate was significantly lower after resection of one slip of the flexor digitorum superficialis tendon compared to other surgical techniques in these patients. We recommend that surgeons assess for possible anatomical variation during surgery for the trigger finger.Level of evidence: IV.
Four hundred thirty-one (431) patients greater than or equal to 65 years of age were studied in clinical trials of deferasirox in the transfusional iron overload setting. Two hundred twenty-five (225) of these patients were between 65 and 75 years of age while 206 were greater than or equal to 75 years of age. The majority of these patients had myelodysplastic syndrome (MDS) (n = 393). In these trials, elderly patients experienced a higher frequency of adverse reactions than younger patients. Monitor elderly patients for early signs or symptoms of adverse reactions that may require a dose adjustment. Elderly patients are at increased risk for toxicity due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range. In elderly patients, including those with MDS, individualize the decision to remove accumulated iron based on clinical circumstances and the anticipated clinical benefit and risks of deferasirox tablets for oral suspension therapy.
In the disclosed methods for manufacturing a regenerated tooth unit, regenerated tooth buds can be cultivated in vivo without pressure or space restricting the shape of the teeth, and the extension of the teeth can be controlled. Said methods allow the transplant of regenerated teeth even in cases in which the missing tooth region is large. One disclosed method includes a step in which a regenerated tooth bud is disposed and cultivated inside a spacer in vivo in a mammal. Said spacer is configured so as to be able to: prevent excessive pressure from being applied to the regenerated tooth bud from tissues inside the body of the mammal; and prevent the regenerated tooth bud from extending more than a maximum tolerance. Furthermore, said spacer is configured such that the regenerated tooth bud disposed inside can connect with the area outside the spacer. Another disclosed method includes a step in which a plurality of regenerated tooth buds are disposed and cultivated inside a spacer in vivo in a mammal.
The invention relates to a hepatocyte growth-promoting factor. Due to the adoption of high performance liquid chromatography analysis, the hepatocyte growth-promoting factor has 12 chromatographic component peaks; the number-average molecular weight of the hepatocyte growth-promoting factor is 10,685 daltons, and the weight-average molecular weight is 11,350 daltons; and the hepatocyte growth-promoting factor comprises 18 kinds of amino acid and 10 trace elements. The concentration of the hepatocyte growth-promoting factor is 15.0 to 22.5mg/ml, and the content of active protein in the hepatocyte growth-promoting factor is 71 to 75 percent. In an in-vitro cell 7721 proliferation-promoting test, the proliferation multiple of the hepatocyte growth-promoting factor which is measured by a methyl thiazolyl tetrazoliym (MTT) assay is 4.5 to 6.0. The invention relates to a preparation and application of the hepatocyte growth-promoting factor. The hepatocyte growth-promoting factor has high activity and high active substance content and is safely used.
The initial dose of idarubicin is 10 mg and the maximum tolerated dose is 20 mg. Idarubicin is first dissolved in water for injection to make a solvent of 2mg/ml, which is then mixed with lipiodol to make an emulsion with a ratio of 1:2. Lipiodol-idarubicin emulsion is slowly injected, followed by embolization with embolic agents.
<P>PROBLEM TO BE SOLVED: To display the medical records of a patient continuously, and to create the medical records at any time during a medical examination.  <P>SOLUTION: When a patient is selected on a patient selection screen (not shown), a screen 40 for the medical records of the patient is displayed. A patient basic information display section 41 for indicating the related information of the patient, a section 42 for displaying observation information for entering the observations of a doctor, and an order display section 43 for entering a prescription, guidance, or the like are provided on the medical records screen 40. References, such as patient information and inspection results, to be referred to in a medical examination are superposingly displayed on the order display section 43 as a reference display section 45, and the section 42 for displaying information on the observations is being displayed as it is. As a result, the doctor can create medical records while seeing the references.  <P>COPYRIGHT: (C)2007,JPO&INPIT
OBJECTIVE: To determine if there is a correlation between maternal short stature and neonatal birth weight among women with adverse outcomes related to labor dystocia.
METHODS: The medical records of singleton deliveries with adverse obstetric outcomes related to labor dystocia during 2014-2020, in a single tertiary center, were reviewed. Outcomes included at least one of the following: cesarean delivery (CD) due to cephalopelvic disproportion (CPD), prolonged second stage, shoulder dystocia, third- or fourth-degree perineal tear. Maternal short stature was defined as height below the 10th centile (short stature group) and normal stature was defined as maternal height between the 10th and 90th centiles (normal stature group). Maternal and neonatal characteristics were compared between the groups.
RESULTS: A total of 3295 women were included, among them, 307 in the short stature group (9.3%, height 1.52 ± 0.02 m) and 2988 in the normal stature group (90.7%, height 1.63 ± 0.04 m). Evaluating the entire cohort revealed similar neonatal birth weights comparing the short and normal stature groups. A subgroup analysis of women after CD due to CPD (n = 296) revealed lower neonatal birth weights in the short stature group (n = 31) compared with the normal stature group (n = 265) (3215 ± 411 vs 3484 ± 427 g, P = 0.001, respectively). Multivariable linear regression was performed for women who underwent CD due to CPD. After adjusting for obesity and diabetes mellitus, short stature and nulliparity were found to be independently associated with decreased neonatal birth weight (266 g less for short stature, P = 0.001, and 294 g less for nulliparity, P = 0.001).
CONCLUSIONS: Among women with short stature, CD due to CPD occurs at lower neonatal birth weights.
Follicular development was monitored dynamically by ultrasound from D8-D11of the menstrual cycle until the follicles developed to ≥16 mm in diameter and ≥7 mm in endothelial thickness, and the day of ovulation was determined by dynamic ultrasound monitoring and detection of serum sex hormone levels. Deferiprone 10 mg po tid was administered from the day of ovulation, and D2 or D3 cleavage stage embryos were transferred 2 or 3 days later, or blastocysts were transferred 5 days later. Deferiprone 10 mg po tid was continued for a total of 14 days after transfer. Cycles were canceled if endothelial thickness was \<7 mm on the day of ovulation or if serum progesterone levels were 5 nmol/L before ovulation.
Virtual group-based handcycling, twice per week for 12 weeks. Each 60-minute session of the intervention will begin with maximum 15 minutes of physiotherapist-led warm-up exercises. Next, a peer-facilitated handcycling session, lasting maximum 45 minutes, will proceed. The handcycling component involves the upper extremities cycling in tandem on a stationary exercise bike. The peer facilitator will be an individual with SCI aged \>50 years, who will co-lead participants alongside the physiotherapist through brief group discussion, maximum 40 minutes of moderate-vigorous handcycling, and maximum 5 minutes of cool-down.
The invention relates to external liquid liniment for treating acnes. Acnes are also called lung wind acnes and are caused by lung heat fumigating, box heating stasis on skins or spicy foot overeating, heat accumulation and dampness production of spleen and stomach and stagnation on skins. The course of the acnes is slowly progressive. As for the liniment, Chinese lobelia herb and radix scutellariae have the functions of clearing away heat and drying dampness, herba schizonepetae, divaricate saposhnikovia root, common scouring rush herb, belvedere fruit and white mulberry root-bark have the functions of diffusing the lung, dispelling wind and arresting itching, radix scrophulariae and radix rehmanniae have the functions of clearing away heat and cooling blood and diminishing swelling and removing stasis, radix stemonae and stiff silkworms have the functions of reducing phlegm and removing fluid retention and stasis, and liquorice has the functions of regulating the middle warmer and relieving internal heat or fever. The above drugs jointly have the functions of relieving internal heat or fever and removing dampness, clearing away heat and cooling blood, diminishing swelling and removing stasis and dispelling wind and arresting itching. Directly aiming at the focuses, the used drugs can heal the acnes quickly and achieve the curative effect of leaving no scars in combination with the external liquid liniment.
PURPOSE:To obtain the titled substance in high concentration and yield, independent of natural environmental condition, etc., by culturing a tissue or cell group of a plant belonging to a specific genus and accumulating an antitumor substance in the adventitious bud and/or adventitious root of the cultured plant. CONSTITUTION:Tissue or cell group of a plant belonging to Putterlickia, Camptotheca, Nothapodytis or Podophyllum genus is washed and sterilized. The sterilized cell group, etc., (e.g. Pterliquia genus) is inoculated in a medium composed of a base culture medium (e.g. White medium), sugars, vitamins, 10<-6>-10<-7>M of auxin and 10<-5>-10<-6>M of cytokinin, etc., and cultured by alternating the irradiation with light of 5,000-10,000 lux for 16-24hr and the maintenance in dark place for 8-0hr to effect the differentiation induction of an adventitious bud or root. The produced bud, etc., is extracted to obtain an antitumor substance such as maytansine from a plant of Putterlickia genus, camptothecin from a plant of Camptotheca genus or Nothapodytis genus or podopyllotoxin, etc., from a plant of Podophyllum genus.