anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain an intravenous infusion liquid preparation, excellent in stability in heat sterilization and storage and capable of rapidly administrating by simple operation in clinical trial and continuously administering without causing lactic acidosis. SOLUTION: This intravenous infusion liquid preparation contains glucose, amino acids, electrolytes and vitamin B1 . The preparation is obtained by housing an infusion liquid agent containing one or more kinds of compounds selected from component of glucose, amino acids and electrolytes in each chamber of a flexible container (e.g. made of plastic) having plural chambers partitioned by a communicatable isolation means. The heat-sterilized infusion liquid preparation is obtained by housing vitamin B1 in at least one chamber of the flexible container. The each blend amount of vitamin B1 , glucose and total amount of amino acids is 0.1-300mg/l, 25-500mg/l and 10-45g/l, respectively. The preparation is applicable to patients undergoing a radical operation for malignant tumor, patients having serious infectious diseases, patients, disordered in lever function, etc.
Subjects in the Supportive therapy group will attend the Royal Brompton Hospital weekly for 10 weeks to meet with person of equal status to the hypnotherapist (e.g. a research assistant, not a medical practitioner) trained to provide counseling and support. Visits will last 50-60 min. Patients will be encouraged to talk about their physical symptoms and any emotional issues, and to discuss how these might be coped with in a better way.
PURPOSE:A permanent waving solution containing a thioglycolic acid salt and a specific orthophosphoric acid salt without a bad irritating smell nor causing excessive phenomenon of forming waves even with passage of time after the application thereof. CONSTITUTION:A permanent waving solution containing 3-10% thioglycolic acid salt and 1-10% orthophosphoric acid salt having any salt of sodium, potassium and ammonium in the first acid group and ammonium salts in the second and third acid groups. The above-mentioned solution is kept at a weakly alkalinity of 8-9.6pH, and the ammonia is converted into ammonium salts to eliminate the volatility and make the solution almost odorless. When the above-mentioned solution is applied to the hair, ammonium ions are dissociated into free ammonia due to the low dissociation constant of the acid groups to which the ammonium ions are bonded and slowly volatilized. The pH of the solution is slowly reduced. After the lapse of time necessary for forming waves, the pH is reduced to 8 or below. Thus, the reductive reaction on the hair is almost stopped, and the hair is not damaged even on allowing to stand.
Drug: Ozone (O3/O2). Treatment: Usual treatment + Ozone therapy by rectal insufflation. O3/O2 concentration progressively increased from 10 to 30 μg/ml; 40 sessions in 16 weeks.
Transcranial direct current stimulation (tDCS) targeting Broca's area has shown promise for augmenting language production in post-stroke aphasia (PSA). However, previous research has been limited by small sample sizes and inconsistent outcomes. This study employed a double-blind, parallel, randomized, controlled design to evaluate the efficacy of anodal Broca's tDCS, paired with 20-minute speech and language therapy (SLT) focused primarily on expressive language, across 5 daily sessions in 45 chronic PSA patients. Utilizing the Western Aphasia Battery-Revised, which assesses a spectrum of linguistic abilities, we measured changes in both expressive and receptive language skills before and after intervention. The tDCS group demonstrated significant improvements over sham in aphasia quotient, auditory verbal comprehension, and spontaneous speech. Notably, tDCS improved both expressive and receptive domains, whereas sham only benefited expression. These results underscore the broader linguistic benefits of Broca's area stimulation and support the integration of tDCS with SLT to advance aphasia rehabilitation.
Cosmetic and/or dermatological composition for treating keratinic fibres comprises a carrier, at least one 2-electron oxidoreductase enzyme, at least one substrate for the enzyme, and at least one anionic amphiphilic polymer derived from at least one hydrophilic monomer and at least one fatty alkyl allyl ether. Preferably the enzyme is an animal, microbial or recombinant uricase and is present in an amount of 0.01-20 (preferably 0.1-5) wt.%. The substrate is selected from uric acid and its salts and is present in an amount of 0.01-20 (preferably 0.1-5) wt.%. The hydrophilic monomer is acrylic acid and/or methacrylic acid. The allyl ether is of formula CH2=CR'CH2OBnR; R' = H or Me; B = CH2CH2O; n = 0-100; and R = 8-30C alkyl, aralkyl, aryl, alkaryl or cycloalkyl, preferably 10-24C alkyl or alkaryl. The allyl ether is especially steareth-10 allyl ether. The polymer is prepared by emulsion polymerisation of 20-60 wt.% (meth)acrylic acid, 5-60 wt.% lower alkyl (meth)acrylate, 2-50 wt.% of the allyl ether and 0-1% of a crosslinking agent. The polymer is a crosslinked copolymer of 40 wt.% methacrylic acid, 50 wt.% ethyl acrylate and 10 wt.% steareth-10 allyl ether. The composition contains 0.05-10 (preferably 0.2-5) wt.% of the polymer. Used for bleaching human hair by applying the composition, optionally containing an auxiliary oxidising agent, and then rinsing; for dyeing human hair by applying a composition as above containing an oxidation dye precursor and optionally a coupler; for permanent waving of human hair by applying a reducing composition, putting the hair under tension, optionally rinsing the hair, applying a composition as above, and optionally rinsing the hair.
OBJECTIVE: To explore a method for establishing a model of ocular accommodative spasm in guinea pigs by using different concentrations of carbachol eye drops and different frequency of administration.
METHODS: Eighteen healthy guinea pigs were selected to establish models for both eyes. Guinea pigs were randomly divided into two groups. Group A was modeled with carbachol eye drops at a concentration of 2 ml:0.1 mg, and group B was modeled with carbachol eye drops at a concentration of 4 ml:0.1 mg. The two groups were further randomly divided into three groups according to the random number table method. Three groups of guinea pigs were established: In the A1, B1 group, the drug was administered one time/day; in the A2, B2 group, the drug was administered two times/day; and in the A3, B3 group, the drug was administered three times/day. Before modeling, retinoscopy optometry was performed on the guinea pigs without mydriasis and mydriasis, and a refractive state was recorded. On subsequent days, modeling was performed again, and carbachol eye drops were administered using the same administration times. Retinoscopy was performed in a dark room without mydriasis on days 1, 3, 7, 14 and 21, and the data were recorded. After optimizing the modeling method, the ciliary muscle tissue of the model guinea pig and normal guinea pig were obtained for hematoxylin and eosin (H&E) staining of paraffin sections to compare the morphological differences under a light microscope.
RESULTS: (1) There was no statistical significance in the interaction of time*0 d and time*drug frequency between group A and group B (P > 0.05). However, the main effect of different dose times varied between group A and group B (P < 0.05), and the modeling effect of three drops was better. (2) The overall modeling methods of groups A and B were not affected by the time factor, but three doses of carbachol eye drops achieved the best modeling effect on the 7th day, and the diopter of guinea pigs stabilized on the 14th and 21st days. (3) To further optimize the medication, the A and B groups were given three drops. On the 7th day, the refractive data of guinea pigs were compared between the groups, and the refractive status of the two groups of guinea pigs before modeling was compared within the groups. There was no statistical difference between the groups (P > 0.05), and there was a statistical difference within the groups (P < 0.05). (4) In the H&E staining of paraffin sections, the color of the ciliary muscle of the guinea pig with spasm of accommodation was darker than that of the normal guinea pig, and the myofilaments were more closely arranged.
CONCLUSION: (1) Carbachol has the effect of contracting the ciliary muscle; (2) Three drops of 2 ml:0.1 mg or 4 ml:0.1 mg of carbachol eye drops can be selected for seven days for modeling.
In low-risk women, probiotic group will be treated with the Active ingredient containing Lactobacillus rhamnosus (LGG) (\> 10x8 CFU) during all pregnancy until delivery. Capsules contain maltodextrin, LGG and vegetal magnesium stearate.
A prospective randomized controlled study with 54 patients in each of the two arms. Group S (control) will undergo the standard laparoscopic procedure and the patients will be placed in supine head up position postoperatively. In group T (interventional); the patients will be positioned in Trendelenburg position once fully awake and cooperative in the post-anesthesia case unit (PACU) and will remain in this position for the first 24 hours postoperatively. Postoperative NRS(numeric rating scale) score for shoulder pain and nausea will be collected at arrival to PACU, \& 4, 6, 12 and 24 hours postoperatively. In addition, total amount of rescue pain and nausea medication used by the patient will be recorded. Data collected will be analyzed and compared between the two groups. The independent t- test will be used to compare postoperative shoulder pain, with NRS scores treated as continuous variable, between the two groups.
The present invention relates to: a polymer carbon nitride; a specific crystal form of the polymer carbon nitride; and a cosmetic composition, an ultraviolet ray-blocking composition, and an external use skin preparation composition which include the polymer carbon nitride. The polymer carbon nitride according to one aspect of the present invention and a crystal form prepared by a specific preparation example thereof can absorb both UVA and UVB, and thus can effectively protect the skin from ultraviolet rays while also being non-toxic and thus suitable for living bodies and lacking photoactivity. Therefore, the polymer carbide nitride and the crystal form can be utilized in a cosmetic composition, an ultraviolet ray-blocking composition and an external use skin preparation composition which are applied to living bodies. In addition, the specific crystal form of the polymer carbon nitride has different characteristics according to the preparation method, and thus can be variously utilized according to the characteristics thereof. Particularly, the crystal form of the polymer carbon nitride according to one aspect can be adjusted to various colors according to the preparation method, and thus can be utilized to obtain a composition having a desired color. Therefore, the crystal form can be suitably utilized to produce products of various colors suitable for the skin tones of individuals.
Oligofructose (OF) is a fructose- based oligosaccharide and defined in the European Union as a dietary fibre. Enzymatically derived from the longer chain inulin in chicory, it is commonly used in processed food to improve mouth feel in fat-free products. OF is poorly digested and absorbed in the small bowel so passes to the colon where it is fermented by the bacteria usually resident in the colon, termed the microbiota. This process produces gases such as hydrogen and sometimes methane, and short-chain fatty acids (SCFAs) which have a variety of roles including nutrition to colonocytes, immunological effects and modulation of intestinal motility. Its presence in the colon alters the composition of the microbiota, with reported potential benefits to health, leading to its description as a 'prebiotic'.

Recently, however, such poorly digested carbohydrates grouped together by the term FODMAP (fermentable oligo-, di-, mono-saccharides and polyols) have been proposed to exacerbate symptoms of irritable bowel syndrome (IBS) such as abdominal discomfort and bloating. Dietary exclusion of foods containing FODMAPs, such as wheat, dairy and certain fruit and vegetables, has been proposed as a treatment for IBS, with some evidence to support this. FODMAPs are thought to induce symptoms either by drawing water into the small bowel by osmosis, or through gaseous distension of the large bowel or a combination of these along with metabolite effects on motility.

The Nottingham GI MRI group has been at the forefront of elucidating the actual effects of FODMAPs on gastrointestinal (GI) physiology. We have published techniques to measure small bowel water content, colonic volume and gas volume and whole gut transit time. We have recently demonstrated that a single, large (40g) dose of inulin leads to an increase in colonic volume, mainly through an increase in colonic gas. Such a dose is beyond the usual range of dietary variation, however. Last year we piloted a model more similar to dietary practice. Participants supplemented their usual diet with 5g OF twice daily for a week. The most striking result was an 18% increase in fasting colonic volume. This could not be explained by changes in colonic gas and may represent proliferation, and increased mass, of the microbiota. That study was an open label, uncontrolled case series so we now wish to test the hypothesis in a double-blind, randomised controlled trial. For explanatory purposes we will also measure whole gut transit, colonic gas volume and hydrogen and methane expired in the breath. For exploratory purposes we will also collect stool and urine samples to allow assessment of the effect on microbiota and their metabolic output.
This study uses EEG, EKG, computerized assessment, blood sampling, and driving simulation.

Individuals recruited will be normal, healthy individuals not currently taking the study drugs. The study will involve five visits, a screening visit as well as four dosing visits. The dosing visits will have a clean (double placebo) and three drugged visits (Xanax and Norco placebo, Xanax placebo and Norco, Xanax and Norco). The screening visit will last about two hours and will include drug and pregnancy testing as well as screening for physical/psychological health. Each of the dosing visits will last approximately five to six hours and will include sleep and food intake surveys, being dosed with study drugs or placebos, AMP assessments, a simulator drive, and wellness surveys. There will also be 4 mL blood sampling before dosing, before driving, and after driving.
PURPOSE:To obtain an osteoclast formation and bone resorption promoter effective in treating metabolic osteopathy for which there has not been any effective therapy up to the present. CONSTITUTION:This osteoclast formation and bone resorption promoter contain a cartilage growth factor having the following physico-chemical properties as an active ingredient: (1) about 16000 Da molecular weight measured by a sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis; (2) having activities in proliferating a cartilage alone or in the coexistence of a fibroblast growth factor and (3) having activities in promoting the differentiating functions of the cartilage. The cartilage growth factor preferably has an N-terminal amino acid sequence represented by formula I and a partial amino acid sequence represented by formulas II to IV. A substance having inhibiting actions on the bone resorption of the medicine is regarded as capable of suppressing the formation of an osteoclast and having effects on suppression of the bone resorption. Thereby, a suitable evaluation system is used to screen a substance capable of inhibiting biological activities of the cartilage growth factor. As a result, the medicine for osteopathy such as osteoporosis is simply obtained.
Amoxicillin and clavulanate potassium tablets (chewable) and amoxicillin and clavulanate potassium for oral suspension contain aspartame which contains phenylalanine. Each 200 mg/28.5 mg chewable tablet of amoxicillin/clavulanate potassium contains 3.4 mg phenylalanine. Each 400 mg/57 mg chewable tablet contains 6.7 mg phenylalanine. Each 5 mL of the 200 mg/28.5 mg per 5 mL oral suspension contains 0.67 mg phenylalanine. Each 5 mL of the 400 mg/57 mg per 5 mL oral suspension contains 1.12 mg phenylalanine. The other formulations of amoxicillin/clavulanate potassium do not contain phenylalanine.
This is a 15 week study, including 10 weeks of active diet intervention. Each participant will receive one dietician counseling session at the beginning of the diet intervention period, two brief follow up dietician phone calls, and 10 diet education handouts delivered via email each week. The main objective of this protocol is to test whether MPN patients can adhere to a diet intervention. The investigators will measure adherence in both arms with patient reported diet recall every two weeks via internet surveys. As exploratory endpoints the investigators will measure changes in inflammatory markers, symptom burden, physical activity level, sleep, and gut microbiome in participants over the course of the study. If successful, the investigators plan to use this intervention in a larger trial to assess whether a diet intervention can effectively change symptom burden and inflammation in MPN patients.
Patients receive letrozole PO QD and abemaciclib PO BID on days 1-14. Patients then undergo standard of care hysterectomy on day 15.
Subjects in both arms of the study will be receiving standard of care RCT and routine follow-up examinations/assessments at 6 months, 1 year, and 2 years post RCT. The difference between the two arms will be the root canal filler material used. The root canals for the treatment arm of the study will be filled with gutta percha at the apical third, gutta percha modified with nanodiamonds and amoxicillin (NDGX) will be used for the middle and coronal thirds.
BACKGROUND: The present study aimed to compare the outcomes of simultaneous bilateral total knee arthroplasty (simBTKA) and staged bilateral total knee arthroplasty (stgBTKA) across different age groups, with a specific focus on patients under and over 65 years old.
METHODS: A retrospective cohort study design was employed to analyze the medical records of patients who underwent simBTKA or stgBTKA between August 2018 and May 2023. Patients were categorized into 4 groups based on age and surgical approach. Various outcome measures including knee extension strength, patient-reported outcome measures (PROMs), length of stay (LOS), operating room time (ORT), and complication rates were evaluated.
RESULTS: The study included a total of 162 patients, with 48 patients in the simBTKA group and 114 patients in the stgBTKA group. Across all age groups, simBTKA resulted in a significantly shorter LOS and ORT than stgBTKA (p < 0.05). However, there were no significant differences in PROMs or in knee extension strength between the two surgical approaches. The complication rates were comparable between the groups, with no reported deaths within one year after surgery.
CONCLUSION: Compared with stgBTKA, simBTKA demonstrated superior efficacy in terms of reduced hospitalization duration and ORT, irrespective of age. Both surgical approaches yielded comparable clinical outcomes and complication rates across all age groups. Overall, the findings suggest that simBTKA is a viable option for appropriately selected patients, offering outcomes comparable to those of stgBTKA, with the added benefit of reduced hospitalization time and operating room utilization.
OBJECTIVE: To assess FEES findings in defining oral feeding safety in children with suspected dysphagia, comparing them with clinical feeding evaluation results.
METHODS: This study comprised a case series involving children with suspected dysphagia, referred for evaluation by otolaryngologists and speech-language pathologists (SLPs) at a Brazilian quaternary public university hospital. These children underwent both clinical evaluations and fiberoptic endoscopic evaluation of swallowing (FEES), with a comprehensive collection of demographic and clinical data. Subsequently, the authors performed a comparative analysis of findings from both assessments.
RESULTS: Most patients successfully completed the FEES procedure (93.7%), resulting in a final number of 60 cases included in the study. The prevalence of dysphagia was confirmed in a significant 88% of these cases. Suspected aspiration on clinical SLP evaluation was present in 34 patients. Of these, FEES confirmed aspiration or penetration in 28 patients. Among the 35 patients with aspiration or penetration on FEES, 7 (20%) had no suspicion on SLP clinical assessment. All seven patients in whom clinical SLP evaluation failed to predict penetration/aspiration had neurological disorders. The median age of the children was 2.8 years, and 49 (81.6%) had neurological disorders, while 35 (58.3%) had chronic pulmonary disease. The most prevalent complaints were choking (41.6%) and sialorrhea (23.3%).
CONCLUSION: FEES can diagnose structural anomalies of the upper aerodigestive tract and significantly contribute to the detection of aspiration and penetration in this group of patients with suspected dysphagia, identifying moderate and severe dysphagia even in cases where clinical assessment had no suspicion.
Vital Exhaustion (VE) refers to a physical and mental state of excessive fatigue, feelings of demoralization, hopelessness, and increased irritability. The short form of the Maastricht Vital Exhaustion Questionnaire (MVEQ) is a widely used measure to assess VE. Despite its utility is broadly recognized, the validity and reliability of the scale have yet to be examined in the Italian context. The present study aimed to evaluate the psychometric properties of the shortened MVEQ in a community sample of Italian older adults. A total of 722 older adults (Mage = 72.97, SD = 7.71; 60.4% females) completed the MVEQ, as well as other self-report questionnaires assessing anxiety, depression and stress in order to evaluate the criterion-related validity of the scale. A confirmatory factor analysis (CFA) was conducted to examine the original MVEQ latent structure. Internal consistency was assessed through model-based omega coefficient. Test-retest reliability was examined by re-administering the MVEQ after three months to a subsample of 568 participants. Factorial invariance tests across gender were conducted by means of multi-group CFAs. The one-factor model showed an acceptable fit to the data. The MVEQ yielded a reliable total score (ω = 0.822) and showed moderate-to-large correlations with measures of anxiety, depression, and stress (r range 0.30 to 0.75, ps < 0.001). Test-retest reliability was supported by an Intraclass Correlation Coefficient (ICC) of 0.661. Lastly, the scale was factorially invariant across gender. Overall, the MVEQ provided evidence of reliability and criterion-related validity in a sample of Italian older adults and may be useful for both clinical and research practices.