anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The diversity of structural variants (SVs) in melanoma and how they impact oncogenesis are incompletely known. We performed harmonized analysis of SVs across melanoma histologic and genomic subtypes, and we identified distinct global properties between subtypes. These included the frequency and size of SVs and SV classes, their relation to chromothripsis events, and the impact on cancer-related genes of SVs that alter topologically associated domain (TAD) boundaries. Following our prior identification of double-stranded break repair deficiency in a subset of triple-wild-type cutaneous melanoma, we identified MRE11 and NBN loss-of-function SVs in melanomas with this mutational signature. Experimental knockouts of MRE11 and NBN, followed by olaparib cell viability assays in melanoma cells, indicated that dysregulation of each of these genes may cause sensitivity to PARP inhibitors in cutaneous melanomas. Broadly, harmonized analysis of melanoma SVs revealed distinct global genomic properties and molecular drivers, which may have biological and therapeutic impact.
PURPOSE: Kinesio taping (KT) is an approach that has been used in the rehabilitation of patients with chronic stroke. The aim of this review is to evaluate the effectiveness of KT alone or combined with other interventions for patients with chronic stroke.
MATERIALS AND METHODS: The search was performed on CENTRAL, EMBASE, PEDro, and five other databases and two trial registries up to July 2022. We included randomized controlled trials that evaluated the effectiveness of KT compared to control interventions. The primary outcomes were upper limb function and gait. We assessed the risk of bias in the included studies using the PEDro scale. The certainty of the evidence was assessed using the GRADE approach.
RESULTS: We included 14 RCTs undertaken in six different countries. PEDro score ranged from 4 to 9 points. There is very-low certainty evidence that KT has no effect on gait, balance, and postural control. We found very-low certainty evidence of a slightly benefit when used in addition to other therapies for gait, balance and postural control, and pain intensity.
CONCLUSIONS: Our study findings show KT does not have enough robust evidence for improving upper limb function, gait, balance and postural control, and pain intensity in chronic stroke patients.
The invention concerns a method for preparing recombinant heterocarpine. The invention concerns in particular the complete heterocarpine sequence (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding heterocarpine, host cells transformed or transfected by said expression vectors and a method for obtaining heterocarpine using said transformed or transfected host cells. The resulting recombinant heterocarpine can in particular be used for preparing a medicine for treating cancer.
The third group will contain healthy women. Measurements will be done at baseline, 6th month and 12th month. Tissue dielectric constant measurement will be applied to upper extremity both affected and unaffected. 6 cm lower point of cubital crease, 8 cm upper point of cubital crease and 10 cm lower point of armpit will be marked on two sides with a soft pen before measurement. Bio Impedance Analysis measurement will be done at both side. Self-adhesive electrodes will be applied related side's foot dorsum and hand dorsum.Impedance ratios will be calculated for each side then dividing process is conducted for determining L-dex ratio.
This is a Phase 1b, open-label, single-arm, multicenter clinical trial for evaluation of safety, tolerability and chemoprotection effects of ALRN-6924 combined with chemotherapy in patients with TP53-mutated, HER2 negative breast cancer without distant organ metastases. All patients will receive the neoadjuvant or adjuvant chemotherapy regimen known as TAC. TAC consists of doxorubicin 50 mg/m2 IV infusion, docetaxel 75mg/m2 IV infusion and cyclophosphamide 500 mg/m2 IV infusion, given on Day 1 of every 3-week cycle for a total of 4-6 treatment cycles according to each patient's individual needs, individual institutional policies and standards of care, as well as investigator discretion. ALRN-6924 1.2 mg/kg will be administered on 3 consecutive days in each treatment cycle, Days 0-2. Prophylactic administration of G-CSF prior to the first instance of Grade 4 neutropenia is not allowed in Cycle 1. Myeloid growth factor support with filgrastim should be administered immediately if a patient is diagnosed with Grade 4 neutropenia.
Between July 2009 and December 2021, all women with storage lower urinary tract symptoms (LUTS) who visited the urogynecological department of a medical center were included. Women without complete data of a 3-day bladder diary (BD) were excluded from this study. The women were allocated into 12 groups according to the study flowchart based on their LUTS, including urinary urgency, stress urinary incontinence, urgency urinary incontinence, nocturia and frequency. MedCalc software was used for statistical analysis. Analysis of variance (ANOVA) was applied, and a P-value of less than 0.05 was considered as statistically significant. Post-hot analyses by the Student-Newman-Keuls test were performed only in those comparisons with p \< 0.05 after ANOVA.
The present invention relates to a traditional Chinese medicine composition for treating avian influenza, which can be used for preventing or treating the avian influenza of chicken and duck. The traditional Chinese medicine composition is prepared by mixing a traditional Chinese medicine compound A, a traditional Chinese medicine compound B and a traditional Chinese medicine compound C, wherein the proportioning ranges are respectively as follows: 180g-420g, 80g-100g and 260-510g. The method for preparing the traditional Chinese medicine mainly comprises four steps of mixing, grinding, stirring and placing in an oxygen-deficient environment. In the specific application process, the proportion of the three pure traditional Chinese medicines by weight is 4: 1:3. The medicine of the invention which is prepared by natural plant has the advantages of no side effect, ideal function, strong function, excellent safety, ideal effectiveness, convenient using and no effect for the egg laying rate of domestic birds of chicken, duct, etc. Furthermore the color of the egg is red and bright and the egg shell is smooth. The immunity of the domestic bird can be increased when the traditional Chinese medicine is used periodically. The traditional Chinese medicine of the invention develops a novel path for preventing the avian influenza virus.
PROBLEM TO BE SOLVED: To obtain a diarrheal symptom-improving agent capable of improving the diarrheal symptom accompanied by the oral ingestion of nutrients after the stoppage of a digestive tract function for a long period, and enabling the smooth transfer to the oral ingestion by compounding a specific amino acid as an active ingredient. SOLUTION: This diarrheal symptom-improving agent contains at least one kind of compound selected from L-glutamine, oligopeptides each containing an L-glutamine residue and their pharmacologically acceptable salts as an active ingredient. The oligopeptides each containing the L-glutamine residue are, e.g. dipeptides and tripeptides, such as glycyl-L-glutamine, L-alanyl-L-glutamine and L-glytaminyl-L-arginine. The diarrheal symptom-improving agent is administered, e.g. at a daily dose of 0.02-0.40 g/kg, when the active ingredient is L-glutamine.
Group 2 will receive sham stimulation (S-tDCS). In the sham stimulation, the same helmet and electrode that is used in the active stimulation will be placed but, in this case, we will apply only a slight current at the beginning and end of the session with the objective of simulating the effects that are experienced with the active stimulation without producing significant cortical stimulation. The active electrode will be placed in the region of the lower right frontal rotation and the reference electrode in the extraencephalic zone (left clavicle). Combined rehabilitation sessions (REGIAplus/tDCS) will be conducted, as indicated above, in weeks 9 and 10 of the assay.
Participants will undergo 4 Transcranial Photobiomodulation (t-PBM) treatment visits and receive 1 irradiance dose per visit. The order of dose administration is randomized so patients receive each irradiance dose (50 mW/cm2; 300 mW/cm2; 770 mW/cm2), as well as a sham dose (0 mW/cm2), once over the 4 treatment visits.
PURPOSE:To obtain a treating agent for osteoporosis containing monocyte- macrophage colony formation stimulating factor as an active ingredient and capable of normally advancing bone formation reduced in side effects. CONSTITUTION:The objective treating agent containing a monocyte-macrophage colony formation stimulating factor (hereinafter referred to as M-CSF) as an active ingredient. M-CSF is e.g. dissolved in sodium chloride solution or distilled water for injection so as be become 10<3> to 10<6> units/ml and the solution is administered by intravenous injection, dropping injection, intramuscular injection, subcutaneous injection, etc. The agent is administered at an amount of 100000 to 20000000 units/adult/each time and daily once to several times continuously for 1-14 day. M-CSF can be prepared by purification of human urine, culture of M-CSF producing cells, gene optical method, peptide fragmentation of peptides having CSF activity, etc.
PROBLEM TO BE SOLVED: To obtain a new compound having platelet aggregation-inhibiting action and useful as an active ingredient for medicinal composition used for treatment or proplylaxis of thrombotic diseases. SOLUTION: This compound is represented by formula I (R<1> is H or a 1-4C lower alkyl), e.g. 4- 2-[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]-1- hydroxyethyl}phenoxyacetic acid. The compound of formula I can be obtained by reducing, e.g. a ketone which is a compound represented by formula II (P is a protecting group of amino) to hydroxyl group to afford a compound of formula III and as necessary, removing a protecting group. Reduction reaction can be carried out by reacting the compound of formula II with a reducing agent in a solvent at -20 to 180 deg.C, preferably -10 to 100 deg.C for 30 min to 24 hr, preferably for 1-10 hr. A metal hydride such as sodium borohydride or aluminumlithium hydride or a compound for catalytic reduction using palladium- carbon, platinum oxide, etc., can be used as the reducing agent.
The invention provides a health cortex lycii oral solution with blood pressure and blood sugar reducing effects. The health cortex lycii oral solution comprises the following raw materials in parts by weight: 10-50 parts of cortex lycii, 10-20 parts of parasitic loranthus, 10-20 parts of poria peel, 10-20 parts of white mulberry root barks, 10-20 parts of selfheal, 10-20 parts of salvia miltiorrhiza, 10-20 parts of ligusticum chuanxiong, 10-20 parts of herba epimedii, 10-20 parts of hedyotis diffusa, 10-20 parts of mulberries, 10-20 parts of schisandra chinensis, 10-20 parts of radix trichosanthis, 10-20 parts of semen cassiae, 10-20 parts of flos sophorae and 10-20 parts of radix rehmanniae. The cortex lycii can be used for treating polydipsia as well as day and night thirst and is capable of inducing urination. Modern pharmacological researches prove that the cortex lycii contains guanidine derivatives and has a blood sugar reducing effect. The health cortex lycii oral solution also has blood lipid and blood pressure reducing effects, the blood pressure reducing effect is related to central nerves, and the health cortex lycii oral solution can be used for blocking sympathetic nerve endings and directly relaxing blood vessels. The health cortex lycii oral solution is fragrant, bitter a little as well as sweet and mellow; and due to the addition of traditional Chinese medicines which have the effects of promoting blood circulation to remove blood stasis, are light in taste and cannot destroy the sweet taste of the cortex lycii, the taste is not influenced, the health cortex lycii oral solution is easily accepted by people, and the blood pressure and blood sugar reducing effects can be better improved.
Levosimendan is given as Bolus (12 µg/kg over 10 min i.v.), starting 10 min before recanalization and additionally as continuous infusion (0.1-0.2 µg/kg/min i. v. for 24 hours).
Arm 11 will be given access to interventions 2, and 3. Video and text content will focus on confidentiality and education about identity.
The invention discloses cereal oil and sweet potato skin care cream which is prepared from pure natural raw materials as well as processed matters thereof. The cereal oil and sweet potato skin care cream comprises the following main raw materials in parts by weight: 10-40 parts of rice bran oil, 20-80 parts of sweet potatoes, 3-10 parts of selectable sesame oil, 3-10 parts of walnut oil and 1-5 parts of perilla oil. The cereal oil and sweet potato skin care cream comprises the following auxiliary raw materials in percentage by weight: 10-40% of pectin, glycerinum and/or water, and 0.1-0.5% of selectable sweet-scented osmanthus oil, litsea cubeba oil, cinnamomum camphora oil, orange peel oil and/or shaddock peel oil, respectively. The formula synthesizes excellent health-care effects of rice bran oil and sweet potatoes and alleviates the flavor of the rice bran oil and converts the original pure liquid state to cream, so that the cream is more suitable and convenient for use. The invention discloses a processing method which comprises the following steps: firstly, steaming and mashing the sweet potatoes; and uniformly stirring, heating, and emulsifying and the like. The processing method is simple and easy to implement without damaging the original effects and functions of the raw materials. If all raw materials are food level raw materials, the cream is a nutritional health-care natural food which can be eaten.
INTRODUCTION: Spontaneous arteriovenous fistulas (AVF), in contrast to iatrogenic or post-traumatic ones, are extremely rare and only sporadically published in the literature. In the absence of exposure risk, the diagnosis of AVF can be challenging, especially if it is an incidental finding.
CASE HISTORY: An 80-year-old female patient presented to our vascular consultation because of swelling of the left leg due to varicosis. For years, she had also noticed that the right foot seemed to be cooler. Percutaneous catheter examinations via the groin had not been performed, and she could not remember any groin injuries.
EXAMINATION AND FINDINGS: Truncal varicosis of the great saphenous vein confirmed clinically and sonographically. In addition, with peripheral pulses obtained, the right foot appeared slightly cooler but not discolored. On auscultation, a systolic-diastolic murmur accompanied by palpable buzzing was heard in the right groin. Color duplex sonography showed a coarse color mosaic pattern between the common femoral artery (AFC) and the anterior saphenous vein (VSAA) in the sense of aliasing ("confetti phenomenon"). A fistula channel between the AFC and VSAA could be visualized, in which very high systolic-diastolic flow velocities prevailed; pulsatile and turbulent flow was present in the region of the crosse-near femoral vein.
THERAPY AND COURSE: Endovenous laser ablation was performed for symptomatic truncal varicosis of the left leg. Under ultrasound-guided compression of the afferent artery and fistula at the right groin, the fistula flow did not stop. The patient was reluctant to undergo a proposed interventional closure of the AVF. In follow-up over 4 years, no signs of cardiac insufficiency or critical limb ischemia developed.
DISCUSSION: Spontaneous femoral AVF is a rarity. Characteristic clinical findings lead to a targeted use of color duplex sonography with correct interpretation of artifacts that can otherwise be easily missed.
Circulating α1-acid glycoprotein (AGP) and C-reactive protein (CRP) are commonly measured to assess inflammation, but these biomarkers fail to reveal the complex molecular biology of inflammation. We mined the maternal plasma proteome to detect proteins that covary with AGP and CRP. In 435 gravida predominantly in <12-week gestation, we correlated the relative quantification of plasma proteins assessed via a multiplexed aptamer assay (SOMAScan®) with AGP and CRP, quantified by immunoassay. We defined a plasma inflammasome as protein correlates meeting a false discovery rate <0.05. We examined potential pathways using principal component analysis. A total of 147 and 879 of 6431 detected plasma proteins correlated with AGP and CRP, respectively, of which 61 overlapped with both biomarkers. Positive correlates included serum amyloid, complement, interferon-induced, and immunoregulatory proteins. Negative correlates were micronutrient and lipid transporters and pregnancy-related anabolic proteins. The principal components (PCs) of AGP were dominated by negatively correlated anabolic proteins associated with gestational homeostasis, angiogenesis, and neurogenesis. The PCs of CRP were more diverse in function, reflecting cell surface and adhesion, embryogenic, and intracellular and extra-hepatic tissue leakage proteins. The plasma proteome of AGP or CRP reveals wide proteomic variation associated with early gestational inflammation, suggesting mechanisms and pathways that merit future research.
Research Question: Will the addition of cast iron pots to the standard of care (nutrition counseling, food recall, prenatal vitamin, +/- iron and vit c) improve the hematocrit of pregnant women with anemia? Study Intervention: To provide a cast iron pot to those pregnant women with anemia who are randomized to intervention group and an aluminum pot to those women in the control group. Women will be blinded to their allocation. Women with a qualifying hemoglobin will meet with our nutritionist (as they would if not enrolled in the study), and she will perform a standardized 24 hour food recall and nutrition counseling according to the standard of care, as well as perform written informed consent. The 24 hour food recall will be submitted to the manufacturer (Nutrition Quest) to calculate the baseline iron intake of each subject. Subjects will be enrolled only if they can agree to incorporate the provided pot into their cooking (in any capacity) 3x/week. Subjects will be called 1x/month and asked about the frequency of pot use over the past month as well as their compliance with iron and vitamin C supplements, if prescribed. Subjects will then also be contacted postpartum to determine satisfaction with the intervention.

Outcome measure: We will be looking at hemoglobin levels in the first, second, and third trimester as well as postpartum (which are all routinely collected labs in pregnancy). Ferritin will be added along with routine labs at approximately 19 weeks as this is often performed in the workup of anemia. No labs outside of routine maternal labs will be performed.
Following bowel surgery, infectious complications, including anastomotic leak (AL), remain major sources of morbidity and mortality. Bowel preparation is often administered with the assumption that gut decontamination reduces post-surgical complications. In this study, we tested this hypothesis using a murine model of colon surgery. The mice were fed either regular chow or a high-fat, high-sugar Western diet. The day before surgery, the mice received one of four interventions: water (control), mechanical bowel preparation (MBP), oral antibiotics (OA), or both MBP and OA. We found no differences in the rates of AL among the experimental groups, and diet did not appear to affect the outcomes. Exploratory analyses showed changes in the gut microbiome consistent with the different treatments, but investigations of fecal short-chain fatty acids and RNA sequencing of colonic tissue did not reveal specific effects of the treatments or the presence of AL. However, we did identify bacterial genera that may be causally associated with AL and developed a predictive index from stool samples as a marker for the presence of AL. Future research is needed to identify and validate a microbial predictive tool and to uncover the microbial-driven mechanisms that lead to AL.
Myocardial ischemia-reperfusion injury (MIRI) is an injury to cardiomyocytes due to restoration of blood flow after myocardial infarction (MI). It has recently gained much attention in clinical research with special emphasis on the roles of mitochondrial autophagy and inflammation. A mild inflammatory response promotes recovery of post-ischemic cardiomyocyte function and vascular regeneration, but a severe inflammatory response can cause irreversible and substantial cellular damage. Similarly, moderate mitochondrial autophagy can help inhibit excessive inflammation and protect cardiomyocytes. However, MIRI is aggravated when mitochondrial function is disrupted, such as inadequate clearance of damaged mitochondria or excessive activation of mitophagy. How to moderately control mitochondrial autophagy while promoting its balance with nucleotide-binding oligomerization structural domain receptor protein 3 (NLRP3) inflammasome activation is critical. In this paper, we reviewed the molecular mechanisms of mitochondrial autophagy and NLRP3 inflammasome, described the interaction between NLRP3 inflammasome and mitochondrial autophagy, and the effects of different signaling pathways and molecular proteins on MIRI, to provide a reference for future research.
OBJECTIVE: The study's objective was to examine whether adherence to three plant-based dietary indices (PDIs) mediated or moderated genetic susceptibility to obesity.
METHODS: Baseline participants were 7037 adults (57% women, aged 55.6 ± 7.7 years) from the CARTaGENE cohort of Quebec adults. Two polygenic risk scores for BMI (PRS-BMI), 92 single-nucleotide polymorphisms and 2 million single-nucleotide polymorphisms, and three plant-based scores were calculated (overall, healthy, and unhealthy). Follow-up participants were 2258 adults with data on obesity outcomes, measured 6 years later. General linear models were used to examine the relationships between PRSs and PDI scores on obesity outcomes. Causal mediation analyses were conducted to assess mediation and interaction models.
RESULTS: The overall- and healthy-PDIs and PRSs were significantly associated with obesity outcomes. Adherence to PDIs did not mediate or moderate genetic susceptibility to obesity. Associations between PRSs and obesity outcomes were partly mediated by meat intake cross-sectionally and whole grains intake among males both cross-sectionally and longitudinally. Higher meat intake had a positive association with obesity outcomes, whereas higher whole grains intake had an inverse association.
CONCLUSIONS: These findings suggest that components of a plant-based diet and a shift away from animal products, specifically meat, might be beneficial for nutrition interventions, particularly among individuals with higher genetic risk of obesity.