anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants received neoadjuvant treatment with dose-dense doxorubicin and cyclophosphamide (ddAC), with administration of doxorubicin 60 milligrams per square meter (mg/m\^2) intravenously (IV) once every 2 weeks (q2w) and cyclophosphamide 600mg/m\^2 IV q2w for 4 cycles, followed by paclitaxel 80mg/m\^2 IV once weekly (qw) for 12 weeks. Pertuzumab (840 milligrams \[mg\] IV loading dose then 420mg IV q3w) and trastuzumab (8 milligrams per kilogram \[mg/kg\] IV loading dose then 4mg/kg IV q3w) were administered along with paclitaxel for 4 cycles (8 cycles of chemotherapy in total prior to surgery). Following surgery, participants received adjuvant treatment with pertuzumab and trastuzumab IV q3w (up to 13 cycles), for a total of 17 cycles of pertuzumab and trastuzumab therapy during the study. Radiotherapy and adjuvant hormonal therapy were also given as clinically indicated. Following treatment completion/discontinuation, participants were followed for safety and efficacy for up to 5 years.
With this group, a yellow stress ball will be used which is 6cm in diameter, of medium hardness and made of high quality silicone, and which returns to its original shape after being squeezed. The researcher will explain to the individuals in the group how they should use the stress ball five minutes before beginning the vaccination and during the procedure. The individuals will be taught to take the stress ball in their right hand, the side on which the vaccination will not be given, and, counting from one to three, to squeeze and release the ball, continuing until the procedure is finished. It will be explained that during the procedure, they should give their attention to the stress ball and focus on squeezing it.
This study is a prospective, multicenter study on patients with a diagnosis of NHL, MM or CLL. All the patients with a diagnosis of NHL, MM or CLL in the participant centers will be purposed to participate. Each patient included will have an interview with a clinical study technician or doctor of occupational medicine. A specific detailed questionnaire has been created for the study. It focuses on specialized professional careers to spread occupational exposures to nuisances (substances and agents) suspected of being associated with NHL, MM or LLC risk. Each questionnaire will be evaluated by a physician expert in occupational disease, to conclude on the parameters exposure to the various suspected carcinogens. The study will cover 300 patients.
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterised by irreversible airflow limitation. The elderly are a vulnerable population for developing COPD. With the growth of age, physiological degenerative changes occur in the thorax, bronchus, lung and vascular wall, which can lead to age-related physiological attenuation of lung function in the elderly, so the prevalence of COPD increases with age. Its pathogenesis has not yet been truly clarified. Mitophagy plays an important role in maintaining the stability of mitochondrial function and intracellular environment by scavenging damaged mitochondria. Currently, studies have shown that trophoblast antigen 2 (TROP2) expression is up-regulated in airway basal cells of patients with COPD, suggesting that TROP2 is involved in the progression of COPD. However, whether it is involved in disease progression by regulating mitochondrial function remains unclear. In this study, compared with non-smoking non-COPD patients, the expression of TROP2 in lung tissues of smoking non-COPD patients and patients with COPD increased, and TROP2 expression in patients with COPD was higher than that in smoking non-COPD patients. To further explore the role of TROP2, we stimulated BEAS-2B with cigarette smoke to construct an in vitro model. We found that TROP2 expression increased, whereas TROP2 silencing reversed the cigarette smoke extract-induced decrease in mitochondrial membrane potential, increased reactive oxygen species content, decreased adenosine triphosphate (ATP) production, increased inflammatory factor secretion and increased apoptosis. In addition, we searched online bioinformatics and screened the gene dynamin-related protein 1 (DRP1) related to mitophagy as the research object. Co-IP assay verified the binding relationship between DRP1 and TROP2. Further study found that TROP2 promoted mitophagy and apoptosis of BEAS-2B cells by up-regulating the expression of DRP1. In addition, PTEN-induced putative kinase 1 (PINK1) is a potential binding protein of DRP1, and DRP1 accelerated mitophagy and apoptosis of BEAS-2B cells by promoting the expression of PINK1. We established a COPD SD rat model by cigarette smoke exposure and LPS instillation and treated it by intraperitoneal injection of si-TROP2. The results showed that TROP2 silencing restored lung function and reduced the secretion of inflammatory factors in bronchoalveolar lavage fluid. In conclusion, TROP2 can be used as a new reference for COPD treatment.
Coral polyps are composed of four tissues; however, their characteristics are largely unexplored. Here we report biological characteristics of tentacles (Te), mesenterial filaments (Me), body wall (Bo), and mouth with pharynx (MP), using comparative genomic, morpho-histological, and transcriptomic analyses of the large-polyp coral, Fimbriaphyllia ancora. A draft F. ancora genome assembly of 434 Mbp was created. Morpho-histological and transcriptomic characterization of the four tissues showed that they have distinct differences in structure, primary cellular composition, and transcriptional profiles. Tissue-specific, highly expressed genes (HEGs) of Te are related to biological defense, predation, and coral-algal symbiosis. Me expresses multiple digestive enzymes, whereas Bo expresses innate immunity and biomineralization-related molecules. Many receptors for neuropeptides and neurotransmitters are expressed in MP. This dataset and new insights into tissue functions will facilitate a deeper understanding of symbiotic biology, immunology, biomineralization, digestive biology, and neurobiology in corals.
PROBLEM TO BE SOLVED: To improve the strength and unravelling and matching properties of a reinforcing material by forming the reinforcing material from an orthoblend fiber made of a superhigh strength resin material which expands long vertically and narrow laterally and is oriented diagonally to the longitudinal direction of a ribbon. SOLUTION: A material 30 is formed from a knitted product or a knit-like texture of a high strength polymer fiber. This high strength polymer contains trains of a pair of parallel yarns 31 and 32 which are positionally oriented at an angle 34 of about 35 deg. respectively and exist alternately. The parallel yarns 31 and 32 are the same in thickness and positioned in the opposite direction to each other with respect to the axis 33 of a ribbon, the direction of the length thereof or the vertical direction thereof. This knitted fabric is formed by a knitting machine from a strand of continuous filament yarns combined on fibers or an odd number of support bodies.
INTRODUCTION: Efforts to reduce primary cesarean birth may include supporting longer second stages of labor. Although midwifery-led care is associated with lower cesarean use, little has been published on associated outcomes of prolonged second stage (≥3 hours of pushing) for nulliparous individuals in US hospital-based midwifery care. Epidural analgesia and the role of passive descent in midwifery-led care are also underexplored in relation to the second stage. In this study, we report the incidence of prolonged second stage stratified by epidural analgesia and/or passive descent. Secondary aims included calculating the odds of cesarean birth, obstetric anal sphincter injury (OASI), postpartum hemorrhage (PPH), and neonatal complications.
METHODS: Data were collected prospectively from a single academic center in the United States from 2012 through 2019. Our cohort analysis of labors attended by midwives for nulliparous, term, singleton, and vertex pregnancies included both descriptive and inferential statistics comparing outcomes between prolonged versus nonprolonged pushing groups. We stratified the sample and quantified second stage outcomes by epidural analgesia and by use of passive descent.
RESULTS: Of the 1465 births, 17% (n = 247) included prolonged pushing. Cesarean ranged from 2.2% without prolonged pushing to 26.7% with prolonged pushing. Fetal malposition, epidural analgesia, and longer passive descent were more common among those with prolonged active pushing. Despite these factors, neither odds for PPH nor poor neonatal outcomes were associated with prolonged pushing. Those with more than one hour of passive descent in the second stage who also had prolonged active pushing had lower odds for cesarean but higher odds for OASI relative to those who had little passive descent before pushing for more than 3 hours.
DISCUSSION: Prolonged pushing occurred in nearly 2 of 10 nulliparous labors. Fetal malposition, epidural analgesia, and prolonged pushing were commonly observed with longer passive descent, cesarean, and OASI. Passive descent in these data likely reflects individualized midwifery care strategies when pushing was complicated by fetal malposition or other complexities.
The invention relates to a Chinese medicinal herb composition of essence replenishment paste used for treating soreness-tired of the waist and the knee, mental sluggishness. The paste aims to provide an externally used paste using completely natural Chinese crude drug as raw material. The technical problems to be solved are that a plurality of kidney invigorating drugs can lead to weak and obesity through oral administration and a series of unhealthy symptoms are shown including cerebrovascular diseases, diabetes mellitus, figure variation, fat and overweight. The invention changes the original dosage form into external applied paste to be directly pasted on Guanyuan acupoint and Shenshu acupoint. The drug action directs to the focus, solving the problem of administration every day and inhibiting roots of inducing cerebrovascular diseases and diabetes mellitus. The prescription is an ancient royal secret recipe transmitted among folks, which is a recipe especially for treating infertility of emperors due to essence lassitude and acratia. Drugs for recovering peripheral nerves, permeating blood capillary and repairing damaged cells are added during the spread of this prescription; according to the nature, the preparation is named as essence replenishment cataplasm.
A system ( 100 ) for providing multiple facility healthcare corporations the ability to assign and maintain shared medical record numbers ( 43 ) across multiple entities. The system establishes a parent/child relationship among the entities to share medical record number ranges, formats, and data. A patient record identifier database ( 102 ) contains patient records in a searchable unit record file ( 50 ) and an identification number file ( 3 ). A search processor ( 105 ) locates relevant records and a rules processor ( 104 ) applies various tests to the returned data in order to assign a medical record number ( 43, 13 ) to a single unique unit reference number ( 2, 5, 11 ) to a person without duplication or conflict with identifiers used at other entities ( 4, 9, 190 ). The reference numbers and their associated medical records are shared among the various entities. The sharing relationships may be altered by authorized users accessing on line file maintenance ( 312 ) and programs ( 311 ).
BACKGROUND: Obesity is a known risk factor for the development of osteoarthritis and the subsequent need for joint replacement. Weight loss has been shown to reduce pain, disability, and the need for joint replacement, particularly in patients with knee osteoarthritis. The aim of this study was to investigate pre-operative weight change in patients with hip, knee, and shoulder osteoarthritis at a regional, public hospital in Australia, to identify opportunities for pre-operative weight-loss intervention.
METHODS: A retrospective review of patients who underwent elective primary total hip (THR), knee (TKR), and shoulder (TSR) replacement for osteoarthritis was conducted between December 2019 and December 2022. BMI data were collected at three time points: (1) general practitioner (GP) referral; (2) orthopaedic clinic review; and (3) pre-admission clinic (PAC) assessment.
RESULTS: A total of 496 patients were included in the study, of which 205 underwent THR, 251 underwent TKR, and 40 underwent TSR. The mean patient age was 67 years, and 46.4% were female. At the time of GP referral, the mean body mass index (BMI) was 31.4 kg/m2. Across the study period, only 2% of patients experienced clinically significant weight loss pre-operatively (≥5% of total body weight).
CONCLUSION: This study has demonstrated that very few patients lose weight prior to undergoing joint replacement in the public sector in Australia. This highlights the need for targeted non-surgical weight loss interventions for patients currently awaiting joint replacement.
Recombinant poxvirus (I) contg. DNA from Morbilli-virus in a nonessential region of the poxvirus genome is new. Also described are: (1) a vaccine for inducing an immunological response in a host animal inoculated with the vaccine, the vaccine comprising a carrier and (I); and (2) a method for protecting a dog against canine distemper, which comprises inoculating the dog. with (I). In (I) the Morbillivirus is the measles virus and the DNA codes for measles virus haemagglutinin glycoprotein and/or measles virus fusion protein. DNA is expressed in host by the prodn. of a measles virus glycoprotein. Poxvirus is a vaccinia, avipox or canarypox virus and contains a promoter for expressing the Morbillivurs DNA.
BACKGROUND: The early impact of type 1 diabetes mellitus (DM1), increased blood pressure and glomerular hyperfiltration (GHF) on kidney damage in adolescents using two urinary markers of kidney injury - neutrophil gelatinase-associated lipocalin (uNGAL) and transferrin (uTransf) - was assessed.
METHODS: The study group consisted of 80 adolescents with DM1, of whom 42 were patients with increased blood pressure (IBP), and 38 were patients with normal blood pressure (NBP). Blood pressure was assessed by 24-hour ambulatory blood-pressure monitoring. All patients showed estimated glomerular-filtration rates (eGFRs) above 90 mL/min/1.73 m2. The control group consisted of 19 healthy, age and gender-matched adolescents.
RESULTS: All diabetic children showed a significant increase in uNGAL (P<0.001). This increase was not related to blood pressure. The uNGAL was elevated in all patients with normal albuminuria, normal eGFR and NBP. The concentration of uTransf was not increased in the entire studied group and was not related to blood pressure. Children with GHF had significantly higher levels of both uTransf (P=0.010) and uNGAL (P<0.001). In patients with GHF, blood pressure was normal. Patients with IBP showed a significantly higher value for triglycerides (r=0.247; P=0.032) and a longer duration of diabetes (r=0.264; P=0.019).
CONCLUSIONS: Diabetes is the leading risk factor for early kidney injury. However, increased blood pressure does not lead to kidney damage, at least in the early stage of DM1. The uNGAL is the early indicator of kidney injury and increases in patients with normal albuminuria, normal glomerular filtration and normal blood pressure. Glomerular hyperfiltration seems to be a marker of diabetic-kidney involvement.
This is an open-label, randomized, multi-center, phase 2 study that will evaluate the efficacy of incorporating mNGS in the management of severe pneumonia on accuracy and efficiency of achieving definite diagnosis of identifying causative pathogens of pneumonia, appropriate antimicrobial therapy and patient outcomes. The diagnosis of pneumonia requires radiological evidence of pneumonia and at least two of the following clinical criteria: new, or worsening cough, new or worsening expectoration of sputum, new or worsening dyspnea, hemoptysis, pleuritic chest pain, and fever (≥38.0°C). Severe pneumonia is defined as pneumonia with hypoxemia requiring orotracheal intubation and mechanical ventilation support.

Written informed consent is needed from the eligible subjects or from their legal guardian at the time of recruitment. After completing informed consent, subjects will be randomized with a 1:1 allocation ratio via a web-based randomization system to receive standard of care (SOC) using culture and serology based work-up for pathogen detection or SOC with additional mNGS method using APGseq ® (Asia Pathogenomics, New Taipei City, Taiwan) for pathogen detection. The treatment for pneumonia is suggested following the Taiwan Guidelines for the Management of Pneumonia published in 2018. After randomization, the subjects will be followed until death, discharged from the hospital or 28 days after randomization whichever comes first. The total study duration is expected to be two years from the first subject enrolled to the final analysis.
Participants in the meditation program will be provided with guided meditation and relaxation audio clips to spend approximately 20 minutes per day on the meditation and relaxation activities and participate each week in a 20-30 minutes online meditation webinar with a certified meditation trainer. All meditation and relaxation exercises can be performed in the comfort of your own home or other place of your choosing. The intervention will be entirely online.
The invention discloses polyethylene glycol dendritic polymers and a preparation method thereof. The polyethylene glycol dendritic polymers are prepared with organic diamine as an initiation core, polyethylene glycol and acrylate as repeated branching units, and double bond or primary amine as a surface functional group. The invention also prepares different algebraic polyethylene glycol dendritic polymers by an enzyme-catalyzed transesterification and then a Michael addition reaction with polyethylene glycol, acrylate and primary amine as starting monomers. The prepared polyethylene glycol dendritic polymers have large cavity inside the molecules which can imbed other small molecules such as drug molecules and the like, and a large number of functional groups on the molecular surface can react with other molecules. The reaction raw materials are safe and non-toxic, and can be excluded from the human bodies quickly. The preparation method adopting the enzyme-catalyzed transesterification and the Michael addition reaction is mild in reaction conditions, green and environment-friendly, low in cost and easy to realize industrialization.
PTBP1 is an oncogene that regulates the splicing of precursor mRNA. However, the relationship between PTBP1 expression and gene methylation, cancer prognosis, and tumor microenvironment remains unclear. The expression profiles of PTBP1 across various cancers were derived from the TCGA, as well as the GTEx and CGGA databases. The CGGA mRNA_325, CGGA mRNA_301, and CGGA mRNA_693 datasets were utilized as validation cohorts. Immune cell infiltration scores were approximated using the TIMER 2.0 tool. Functional enrichment analysis for groups with high and low PTBP1 expression was conducted using Gene Set Enrichment Analysis (GSEA). Methylation data were predominantly sourced from the SMART and Mexpress databases. Linked-omics analysis was employed to perform functional enrichment analysis of genes related to PTBP1 methylation, as well as to conduct protein functional enrichment analysis. Single-cell transcriptome analysis and spatial transcriptome analysis were carried out using Seurat version 4.10. Compared to normal tissues, PTBP1 is significantly overexpressed and hypomethylated in various cancers. It is implicated in prognosis, immune cell infiltration, immune checkpoint expression, genomic variation, tumor neoantigen load, and tumor mutational burden across a spectrum of cancers, with particularly notable effects in low-grade gliomas. In the context of gliomas, PTBP1 expression correlates with WHO grade and IDH1 mutation status. PTBP1 expression and methylation play an important role in a variety of cancers. PTBP1 can be used as a marker of inflammation, progression and prognosis in gliomas.
The present invention relates to a preparation for treating fatty liver and alcoholic liver and a preparation method thereof. The preparation comprises the following crude drugs of 10 to 43 portions of Chinese white olive, 10 to 43 portions of giant knotweed rhizome, 29 to 70 portions of malt, 5 to 20 portions of radish seed and 3 to 14 portions of rice sprout by weight. The fresh Chinese white olive is crushed, pressed, taken with juice, filtered, concentrated and dried to make powder which is uniformly mixed with extract of four kinds of traditional Chinese medicine of giant knotweed rhizome, radish seed, malt and rice sprout. The mixed materials are dried, pulverized, sieved and encapsulated. The Chinese white olive extract of the present invention can be used for suppressing or inactivating 68 to 1 strains of influenza virus, the giant knotweed rhizome has inhibiting effects to seven typical virus strains in different degrees, and the Chinese white olive extract and the giant knotweed rhizome have direct antiviral activity through the verification of pharmacology. The present invention has good effects on treating fatty liver and alcohol liver. The present invention has the advantages of therapy effect on hyperlipemia and fatty liver, functions of sobering up and protection of the liver, low cost, convenient administration and safety.
Breast density is an established physical risk factor for breast cancer, applicable to the entire female population in a pre-breast-screening program and, unlike other risk factors, was shown to be affected by an intervention treatment. High breast tissue density is associated with increased risk of breast cancer. Transillumination Breast Spectroscopy (TIBS) uses a white light to provide spectral information on breast tissue density and composition (e.g. water, lipid, hemoglobin and other biomolecules). The overall goal of the TIBS program is to develop a technique that can identify individuals at high risk for breast cancer who would benefit most from improved screening methods and a risk reducing intervention (e.g. diet and lifestyle changes) and can monitor the efficacy of the risk reducing intervention itself in an individual. In a previous study, we demonstrated a high correlation between breast density assessed by TIBS and density identified by x-ray mammography. The current study is testing TIBS ability to monitor changes in an individual's breast density over time
The utility model discloses a traditional Chinese medicine external plaster for aphthous stomatitis, relating to the traditional Chinese medicine external plaster. The traditional Chinese medicine external plaster for aphthous stomatitis is a rectangular or square sheet, a sticking layer is arranged on the periphery at the bottom layer of the plaster, the center of the bottom layer is provided with medicine area for placing traditional Chinese medicine for aphthous stomatitis, and an outer film layer is covered on the sticking layer and the medicine area. The periphery of the medicine area arranged in the center of the bottom layer is provided with or not provided with upward heaves or downward concave parts with heights of one to six millimeters. The medicine liquid inside the medicine storage area is wrapped in an inner film. The medicine powder inside the medicine storage area is put between the bottom layer and the outer film layer or wrapped in the inner film. The size of the plaster is 6 to 8*7 to 11 centimeters. The utility model has reasonable design, a simple structure, easy implementation, convenient use, reliable healing effect, convenient carryover, simple operation, easy clinical application, ensures that the ancient prescription is popularized and applied, and the tradition of the Chinese medicine is carried forward.