anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Two 3-hour laboratory visits (separated by 6 to 18 days) will be conducted. During the first laboratory visit, anthropometric measurements, pulmonary function tests and CPET on a cycle ergometer will be performed. During the second laboratory visit, spirometry will be repeated to ensure stability of the participants health state (particularly relevant for individuals with COPD). Thereafter, the 6MST and 6MWT will be performed in a randomized order, separated by a rest period of at least 30 minutes.
The aim of the study is to perform contrast-enhanced (CE) magnetic resonance imaging (MRI) at OHSU on subjects with diagnosed prostate cancer. This pilot project will study 20 subjects prior to their next scheduled clinical procedures (biopsy or radical prostatectomy). Data from this project will be used to explore new capabilities of the software platform developed under current SBIR funding. CE-MRI will involve the use of an extracellular (Gadolinium based, Gd) contrast agent. When Gd is used, (dynamic-contrast-enhanced) DCE-MRI signal intensity time-course data will be analyzed analytically using the so called "shutter-speed" paradigm which takes into account of the effects of finite water exchange kinetics. Region of interest (ROI) and high resolution (\~millimeter) parametric maps of pathophysiologic quantities, such as tumor vessel permeability, tumor perfusion, extracellular extravascular volume fraction, will be generated from the DCE-MRI data. All parameters will be compared to literature results for software validation and correlated with pathology for clinical potential.
Patients receive selpercatinb PO BID on days 1-28. Treatment repeats every 28 days for up to 7 cycles in the absence of disease progression or unacceptable toxicity. Patients then undergo standard of care surgery.
Epidural and intrathecal administration of this product is not recommended. Reports of serious medical events, including death, have been associated with epidural and intrathecal routes of corticosteroid administration (see ADVERSE REACTIONS: Gastrointestinal and  Neurologic/Psychiatric). 

Ophthalmic 

Use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to bacteria, fungi, or viruses. The use of oral corticosteroids is not recommended in the treatment of optic neuritis and may lead to an increase in the risk of new episodes. Corticosteroids should not be used in active ocular herpes simplex. 

Adequate studies to demonstrate the safety of triamcinolone acetonide injectable suspension use by intraturbinal, subconjunctival, sub-Tenons, retrobulbar and intraocular (intravitreal) injections have not been performed. Endophthalmitis, eye inflammation, increased intraocular pressure and visual disturbances including vision loss have been reported with intravitreal administration. Administration of triamcinolone acetonide injectable suspension intraocularly or into the nasal turbinates is not recommended. 

Intraocular injection of corticosteroid formulations containing benzyl alcohol, such as triamcinolone acetonide injectable suspension is not recommended because of potential toxicity from the benzyl alcohol.
The participants will perform exercises (balance and resistance training) like hydrotherapy group but out of the aquatic environment, during a 12 weeks training period (3sessions/week). Training volume and intensity we will increase systematically over 12 weeks.
The invention discloses medicinal liquor for treating osteoproliferation and femoral head necrosis. The preparation method is that 50-150g of dry elm root is added in 500g of drinking spirit with alcoholic strength of 38-60, the dry elm root is soaked in the drinking spirit for 15-60 days to obtain 500g of soak solution, and 0.5-10g of cartialgenous and 1-25g of ginseng are added and soaked in the 500g of soak solution for 10-30 days to obtain the medicinal liquor. 75g-100g of medicinal liquor is drunken everyday at a plurality of times by the principle that liquor fume is kept uninterrupted. Fifteen days belong to one treatment course. The number of treatment courses is three to five according to the seriousness of the illness. The used amount of cartialgenous and ginseng can be discretionarily reduced according to the physical conditions of patients. The medicinal liquor has the functions of ablating bone spur, repairing periosteum, tonifying kidney yang, benefiting essence and blood, strengthening bones and muscles, reinforcing vital energy, relieving depletion, promoting production of body fluid and inducing sedation of mind, no relapse occurs after the medicinal liquor is taken and toxic side effect is not caused.
Tumor recurrence and metastasis are important factors affecting postoperative survival in hepatocellular carcinoma (HCC) patients. ADP Ribosylation factor-like GTPase 8B (ARL8B) plays a crucial role in many biological processes, including lysosomal function, immune response, and cellular communication, all of which are related to the occurrence and development of tumors. However, its role in HCC remains unclear. Herein, we revealed that ARL8B is consistently elevated in HCC tissues compared to normal liver tissues, suggesting an unfavorable outcome in HCC patients. Increased ARL8B levels promoted the malignant phenotype of HCC in vitro and in vivo. Notably, ARL8B also induced epithelial-to-mesenchymal transition (EMT) in HCC cells. Mechanistically, the results of bioinformatics analysis combined with mass spectrometry revealed the potential downstream target molecule RAB2A of ARL8B. ARL8B directly interacted with RAB2A and increased the levels of GTP-bound RAB2A, thereby contributing to the activation of the extracellular signal-regulated kinase (ERK) signaling pathway. Interestingly, knockout of ARL8B in Hep3B cells enhanced the antitumor activity of lenvatinib in vitro and in vivo. Furthermore, AAV-shARL8B enhanced the inhibition of HCC growth through lenvatinib, providing new insights into its mechanism of action in lenvatinib-insensitive patients. In conclusion, ARL8B promotes the malignant phenotype of HCC and EMT via RAB2A mediated activation of the MAPK/ERK signaling pathway and is expected to be a valuable prognostic indicator and therapeutic target for HCC patients.
Identifying and resolving molecular complexities underlying chronic neuropathic pain is a significant challenge. Among the numerous classes of histone deacetylases, Class I (HDAC 1-3) and Class III (sirtuins) have been best studied in experimental pain models where inhibitor pre-treatments but not post-treatments abrogate the development of pain-related behaviors. Post-treatment here in week 3 with less well-studied Class IIa HDAC4/5 selective inhibitor LMK235 diminishes the trigeminal ganglia increases of HDAC5 RNA and protein in two chronic orofacial neuropathic pain models to levels measured in naïve mice at week 10 post-model induction. HDAC4 RNA reported in lower limb inflammatory pain models is not evident in the trigeminal models. Many other gene alterations persisting at week 10 in the trigeminal ganglia (TG) are restored to naïve levels in mice treated with LMK235. Important pain-related upregulated genes Hoxc8,b9,d8; P2rx4, Cckbr, growth hormone (Gh), and schlafen (Slfn4) are greatly reduced in LMK235-treated mice. Fold increase in axon regeneration/repair genes Sostdc1, TTr, and Folr1 after injury are doubled by LMK235 treatment. LMK235 reduces the excitability of trigeminal ganglia neurons in culture isolated from nerve injured mice compared to vehicle-treated controls, with no effect on neurons from naïve mice. Electrophysiological characterization profile includes a shift where ∼20% of the small neurons recorded under LMK235-treated conditions are high threshold, whereas none of the neurons under control conditions have high thresholds. LMK235 reverses long-standing mechanical and cold hypersensitivity in chronic trigeminal neuropathic pain models in males and females (5,10 mg/kg), preventing development of anxiety- and depression-like behaviors. PERSPECTIVE: Data here support HDAC5 as key epigenetic factor in chronic trigeminal neuropathic pain persistence, validated with the study of RNA alterations, TG neuronal excitability, and pain-related behaviors. HDAC5 inhibitor given in week 3 restores RNA balance at 10 weeks, while upregulation remains for response to wound healing and chronic inflammation RNAs.
Due to the necessity of collecting data from a large sample to test the research's hypotheses, the questionnaire was chosen as the data collection instrument. The Physiotherapy Mobile Acceptance Questionnaire (PTMAQ) scale developed by Blumenthal et al. \[6\] was translated into Turkish and used for data collection on the variables of the study. In this scale, it was seen that a total of 8 expressions belonging to the Perceived usefulness (4 expressions) and Perceived ease of use (4 expressions) variables were used by making use of the TAM model to reveal the attitudes of the participants (physiotherapist) that could affect their intentions towards mHealth practice. Then, a question consisting of 4 statements was asked to reveal the effect of these variables on the intention to use of early adopters. Finally, 18 statements were used to measure the effect of intention to use on intention/likelihood to recommend an mHealth tool for specific clinical purposes.

Based on the clinical usefulness of MWT, these 18 statements want to determine the probability of physiotherapists recommending MWT to patients based on the clinical usefulness of using MWT in 3 dimensions (gait speed, gait quality and balance, pain/cognitive status). Responses were requested in a 5-point Likert format to the statements in the scale, according to which "1=Strongly Disagree" means "5=Strongly Agree". For the scale adaptation procedure, Blumenthal et al., the creators of the PTMAQ scale, were contacted via email and permission was secured. After that, five academics who had an excellent command on English translated it into Turkish. Attempts were made to establish language validity using the back translation technique. It was translated into the target language by an expert in the field of English, and the similarity was determined by translating it from the target language into English. Consequently, it was determined that the forms created independently in the two languages are comparable. Before conducting field research, a draft questionnaire was administered to forty physiotherapists, who were then interviewed face-to-face about concepts and expressions. In this manner, the potential miscommunication-causing wording errors in the questionnaire were reviewed, and the questionnaire was finalized.
PURPOSE: A pharmaceutical composition containing Ampelopsis japonica Makino extract is provided to prevent and treat dementia and Parkinson's disease. CONSTITUTION: A pharmaceutical composition for preventing and treating dementia or Parkinson's disease contains Ampelopsis japonica Makino extract as an active ingredient. The extract is isolated using water, C1-C2 low alcohol or a mixture thereof. The dementia includes Alzheimer's disease, vascular dementia, or (MCI)(mild cognitive impairment). A health food for preventing and treating dementia or Parkinson's disease contains the extract as an active ingredient. A method for preparing the extract comprises: a step of adding an extraction solvent to dry Ampelopsis japonica Makino and extracting; a step of filtering the extract; and a step of concentrating the extract by reduced pressure.
Fludarabine 10 mg/m2 over 1 hour. Clofarabine 40 mg/m2 diluted in normal saline to produce a final concentration of 0.4 mg/mL, infused over 1 hour. Busulfan dose calculated to achieve a systemic exposure dose of 6000 µMol-min IV over 3 hours every 24 hours, immediately after Clofarabine. All delivered on 4 consecutive days (days -6 through -3). Stem cell transplant Day 0.
Being poikilohydric, lichens are inherently exposed to alternating desiccation and hydration cycles. They can exhibit extraordinary resistance to extreme temperatures in a dehydrated state but thermal thresholds for hydrated lichens are lower. The ability of the lichen Cetraria aculeata to recovery after high temperature treatment (40°C, 60°C) at different air humidity levels (relative humidity [RH]: <15%, 25%, 50%, 75%, ≅100%) was examined to find a linkage between passive dehydration of the lichen and its physiological resistance to heat stress. The response to heating was determined by measuring parameters related to photosynthesis and respiration after 2- and 24-h recovery. A higher RH level resulted in a slower decline in relative water content (RWC) in hydrated thalli. In turn, the stress resistance of active thalli depended on the ambient humidity and associated RWC reduction. Elevated temperature had a negative impact on bioenergetic processes, but only an unnatural state of permanent full hydration during heat stress resulted in a lethal effect. Hydrated lichen thalli heated at 40°C and 50% relative humidity (RH) tended to be least susceptible to stress-induced damage. Although atypical climatic conditions may lead lichens to lethal thresholds, the actual likelihood of deadly threat to lichens due to heat events per se is debatable.
Ocular Rosacea (OR) is a chronic inflammatory and neurovascular diseases of the ocular surface and eyelids, associated with abnormal tear film lipids that can lead to corneal neovascularization, loss of transparency and ulceration. Here, the inventors show that the combination of mineralocorticoid receptor blockade in association with local ocular glucocorticoids that have high GR binding affinity, have superior effects as compared to MR blockade alone, without the side effects of glucocorticoids on corneal wound healing. The combination of MR antagonist and low dose of a GR activator further reduces corneal edema, corneal neovascularization and improves corneal wound healing. The combination of MR antagonist and triamcinolone that has a strong GR binding affinity reinforces the beneficial effects of MR antagonists. Finally, the inventors show that MR is overexpressed in ocular surface tissues and Meibomian glands of patients with ocular rosacea, and that transgenic rats that over express the human MR have molecular markers in their meibomian glands, similar to those of patients with OR. Thus, MR antagonists and GR agonist with strong GR affinity is a suitable combination for the treatment of OR.
A unique topical treatment for diseases of joints and soft tissues with a proven scientific basis. The carrying agent is DMSO or (dimethyl sulfoxide) in purified form. This has ability to carry molecules of molecular weight 1000 Daltons or less through the skin. DMSO is also a proven anti-inflammatory for the treatment of joint and soft tissue diseases. By adjusting the acidity one can prepare a unique stable topical gel containing 5% glucosamine (molecular weight 200 Daltons) for the treatment of joint and ligament diseases. By adding 5% MSM we include a powerful anti-oxidant of sufficient low molecular weight to also be delivered through the skin. No other topical application presently available for the treatment of joint and soft tissue disorders can make such claims with scientific fact. No other topical can claim glucosamine, MSM, an anti-inflammatory and anti-oxidant in sufficient concentrations through the skin to have a beneficial affect on joints and soft tissues.
Swedish massage session of 30 minutes duration, twice weekly for four weeks followed by once weekly for four weeks over a eight (8) week period. Total intervention = 12 sessions for 360 minutes.
This study aimed to appraise effectiveness and tolerability of lidocaine 5% spray in treatment of patients with premature ejaculation (PE). The current study has been designed as a randomized single-blind placebo-controlled clinical trial. It was done on 150 lifelong PE patients with normal erection. They were randomized evenly categorized into two treatment groups. Group 1 (n₌75); was given on demand lidocaine 5% spray for 8 weeks. Group 2 (n₌75); was given placebo in form on demand alcohol spray for 8 weeks. All medications were applied on the glans penis for 10-20 minutes and then cleaned before planed sexual intercourse. Patients were evaluated with Arabic Index of Premature Ejaculation (AIPE) scores, intravaginal ejaculatory latency times (IELTs), and frequency of sexual intercourse before and after treatments.
The present invention relates to a method for producing a wild ginseng callus having a polyphenol extraction yield increased by using an ultrahigh pressure emulsifier, and to a method for producing a composition containing the same to protect UV rays, ensure anti-inflammation, and ensure anti-oxidation. A wild ginseng callus is mass-cultured and produced by using a bioreactor, and a culture medium is removed. Then, the wild ginseng callus is mixed with distilled water, and is made to have an increased polyphenol extraction yield by using an ultrahigh emulsifier. Then, a wild ginseng callus extract having effects in protecting UV rays, ensuring anti-inflammation, and ensuring anti-oxidation is produced. By using human body-derived corneum generating cells, the wild ginseng callus extract has effects in reducing cell toxicity, protecting UV rays, and inhibiting expression of interleukin 6. The wild ginseng callus extract, as a material having a superoxide removing enzyme activity increased dependently on concentration, can be used for a composition for protecting UV rays, ensuring anti-inflammation, and ensuring anti-oxidation, and thus can be used as skin external application cosmetic product materials having various shapes.
FIELD: medicine, pharmacy. SUBSTANCE: invention proposes novel agent against common cold diseases and composition based on thereof. Agent represents mixture of sugar alcohols containing 6-O-α-D-glucopyranosyl-D-sorbitol and 1-O-α-D- glucopyranosyl-D-mannitol known early as agent for prophylaxis and treatment of caries or diabetes mellitus that shows antiviral and antibacterial effect. Composition based on thereof comprises also 0.5- 10 mg of zinc represented as it inorganic or organic salt per 1 g of indicated mixture of agent. Agent shows the enhanced effectiveness as regards to rhinovirus as compared with effect of zinc acetate or zinc gluconate. EFFECT: expanded assortment of agent of claimed designation, valuable medicinal properties of agent. 17 cl, 2 dwg, 1 tbl
STUDY OBJECTIVES: Sleep issues are common for people with neurodegenerative conditions, yet research has focused on specific aspects of sleep. While important, a more holistic approach to investigating sleep, termed "sleep health," considers sleep's positive and negative aspects. Current studies exploring sleep health have lacked a control group for reference. For the first time, this study investigated the sleep health of people living with multiple sclerosis and Huntington's disease (HD) and compared it with a community sample.
METHODS: 111 people, including 43 with multiple sclerosis, 19 with HD, and 49 from a community sample, participated in this study. The data, including actigraphy, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale, were collected as part of ongoing research studies. Seven sleep health domains were determined from the collected data, and a composite sleep health score was developed. Analysis of variance and independent t tests were performed to identify population and sex differences.
RESULTS: The HD group had higher sleep regularity and lower sleep rhythmicity than the multiple sclerosis and community sample groups. The HD group had significantly less sleep duration than the multiple sclerosis group. No significant differences between the groups were observed in the sleep health composite score. Males had significantly higher sleep regularity within the HD group but significantly lower sleepiness scores in the community sample.
CONCLUSIONS: These findings indicate that people with HD may experience greater variance in their wake times, therefore decreasing the consistency of being awake or asleep 24 hours apart. Understanding the mechanisms for this should be explored in people with HD.
CITATION: Turner M, Griffiths M, Laws M, Vial S, Bartlett D, Cruickshank T. The multidimensional sleep health of individuals with multiple sclerosis and Huntington's disease and healthy controls. J Clin Sleep Med. 2024;20(6):967-972.
47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of a supernumerary X chromosome in affected females and is associated with a variable cognitive, behavioral, and psychiatric phenotype. The effect of a supernumerary X chromosome in affected females on intracortical microstructure is currently unknown. Therefore, we conducted 7 Tesla structural MRI and compared T1 (ms), as a proxy for intracortical myelin (ICM), across laminae of 21 adult women with 47,XXX and 22 age-matched typically developing females using laminar analyses. Relationships between phenotypic traits and T1 values in 47,XXX were also investigated. Adults with 47,XXX showed higher bilateral T1 across supragranular laminae in the banks of the superior temporal sulcus, and in the right inferior temporal gyrus, suggesting decreases of ICM primarily within the temporal cortex in 47,XXX. Higher social functioning in 47,XXX was related to larger inferior temporal gyrus ICM content. Our findings indicate an effect of a supernumerary X chromosome in adult-aged women on ICM across supragranular laminae within the temporal cortex. These findings provide insight into the role of X chromosome dosage on ICM across laminae. Future research is warranted to further explore the functional significance of altered ICM across laminae in 47,XXX.
The invention discloses a canned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy. The canned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy is developed through adopting Metaplexis japonica (Thunb.) Makino and Miichthys miiuy as raw materials and adding Goodyera kwangtungensis Tso., Radix Ophiopogonis and fruit of Swida alba Opiz. Metaplexis japonica (Thunb.) Makino and Miichthys miiuy which are scarce are used to make the canned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy, the Miichthys miiuy is aired to reach unique mouthfeel, and air drying of the Miichthys miiuy and boiling of perfumery oil prolong the shelf life of cans; the nutritional values of the Metaplexis japonica (Thunb.) Makino and Miichthys miiuy are fully used; and the mutual compatibility of the Metaplexis japonica (Thunb.) Makino and Miichthys miiuy with traditional Chinese medicines makes the canned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy have synergism and have cough relieving and phlegm resolving effects. The anned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy is eaten for a long term to obviously improve the discomfort of people with cold induced coughs and much phlegm. A making method of the canned Metaplexis japonica (Thunb.) Makino flavor Miichthys miiuy has the advantages of simplicity, easiness in realization, and realization of batch production.