anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: To determine and compare the opportunistic respiratory pathogenic index (ORPI) and prevalence of respiratory pathogens between clean and unclean removable prostheses.
METHODS: A cross-sectional study was conducted among 97 removable prosthesis wearers at a teaching dental hospital. Participants' prosthesis hygiene was grouped into clean and unclean. After prosthesis plaque samples were sequenced using the Type IIB Restriction-site Associated DNA Sequencing for Microbiome method, the prevalence was assessed for the presence of respiratory pathogens on each sample. The ORPIs for clean and unclean prostheses were quantified based on the sum of the relative abundance of respiratory pathogenic bacteria in a microbiome using a reference database that contains opportunistic respiratory pathogens and disease-associated information.
RESULTS: A total of 30 opportunistic respiratory pathogens were identified on the removable prostheses. Eighty-one (83.5 %) removable prostheses harboured respiratory pathogenic bacteria. Stenotrophomonas maltophilia (34.0 %), Pseudomonas aeruginosa (27.8 %), and Streptococcus agalactiae (27.8 %) were the top three prevalent respiratory pathogens detected in plaque samples. There was a significantly higher prevalence of respiratory pathogens residing on unclean than clean prostheses (P = 0.046). However, the ORPIs in both groups showed no statistically significant difference (P = 0.516).
CONCLUSIONS: The ORPIs for both clean and unclean prostheses demonstrated a similar abundance of respiratory pathogens. However, the high prevalence of respiratory pathogens residing on unclean prostheses should not be underestimated. Therefore, maintaining good prosthesis hygiene is still important for overall oral and systemic health, even though the direct link between prosthesis cleanliness and reduced abundance of respiratory pathogens has not been established.
CLINICAL SIGNIFICANCE: The association between the prevalence of respiratory pathogens and unclean removable prostheses has been demonstrated and might increase the theoretical risk of respiratory disease development.
The Plantar Fascia (PF) is a thick, fibrous sheath located in the middle of the sole of the foot, starting from the tuber calcanei in the calcaneus and extending to the level of the middle phalanges. It is a tendinous aponeurosis rather than a true layer of fascia and is an important static support for the longitudinal arch of the foot. Plantar Fasciitis (PFs) is inflammation and thickening of the PF where it attaches to the calcaneus. PFs are the most common cause of heel pain. It has been reported to occur in 10% of people during their lifetime. It is more common between the ages of 40-60. Although its main etiology is not fully understood, the most common theory is; microscopic tears as a result of mechanical overstretching of the fascia followed by chronic inflammation, but histological studies lack evidence to support inflammation. Diagnosis is made by physical examination and radiological examinations (ultrasonography, radiography). On physical examination, there is localized tenderness medial to the calcaneal tuberosity. In the treatment of plantar fasciitis, there are many applied methods such as anti-inflammatory agents, orthostotic supports, night splints, physical therapy, corticosteroid applications, night splint use, plastering, rest, lifestyle modification, laser, taping, exercise and ESWT.

Kinesio tapes, which have been used in the conservative treatment of plantar fasciitis in recent years, are elastic tapes similar to the structural properties and flexibility of human skin, without limiting joint movements. Kinesio taping technique provides physiological effects on skin, fascia, muscle and joint. After applying kinesio tape, it raises the skin in the taped area, increasing the space between it and the muscles and relieving the pressure in that area. It also helps to reduce tension and sensitivity by increasing blood circulation and prevents stimulation of pain receptors.

Peloids (medical mud) are organic or inorganic substances formed as a result of geological and/or biological events. They can be found in nature as fine particles, or they are made into small, fine particles by some preliminary preparation processes. Peloidotherapy is a special balneotherapy method made with natural mud. It is used in the treatment of diseases such as degenerative joint diseases, soft tissue rheumatism, lumbardiscopathy, cervical discopathy, chronic low back and neck pain, joint pain. In both national and international scientific studies on peloid treatment, it has been shown that pain in patients decreases, physical functions improve, quality of life increases, and the amount of painkillers use decreases.

We could not find any study comparing Peloidotherapy and Kinesioband methods routinely used in the treatment of PF in the literature.
Allogeneic transplant using human leukocyte antigen (HLA) matched donors, both related and unrelated, has proven curative for patients with various immunodeficiencies, including those with ongoing infections. However, donor availability remains a limiting factor in the application of this treatment modality. For this protocol, a haploidentical donor is a related donor with more than 1 HLA antigen mismatch. The use of haploidentical related donors has in the past been fraught with a greater rate of complications related to both higher rates of graft versus host disease (GvHD) and delayed immunorecovery. Newer transplant regimens appear to have diminished these risks and improved outcomes. We propose using a reduced intensity novel conditioning regimen using alemtuzumab, targeted busulfan, and low dose total body irradiation (see schema below) followed by post-transplant cyclophosphamide for patients with chronic granulomatous disease (CGD) who do not have an HLA matched donor but whose circumstances necessitate the use of a potentially curative, albeit high-risk treatment modality. However, patients with CGD have high rates of Crohn s Disease-like inflammatory bowel disease, predominantly colitis, where uncontrolled severe IBD may increase risk of GvHD. For this reason, the first 10 patients enrolled will exclude those deemed to have intestinal inflammation in the severe category.

As part of the study design, the protocol will enroll patients sequentially.
Participants in Arm B will receive one subcutaneous injection of pegylated interferon-alpha2a on day 0. The dose of pegylated IFN-alpha2a will be 180 mcg. Simultaneously with interferon-alpha2a, a 15 mg tablet of panobinostat will be administered on day 0. Participants will also receive panobinostat as an oral tablet on days 2 and 4 of the treatment week.
NEW MATERIAL:A compound shown by the formula I (Z is H or OH; R is 3- 7C alkyl). EXAMPLE:2,2- Dimethyl- 4-[3'-( t-butyldimethylsilyloxy )- 1'- octenyl]- cyclopentanone. USE:A drug for hypotension. An antihypertensive agent. An inhibitor for secretion of acid in the stomach. An inhibitor for bronchospasm. Useful as a remedy and preventive for thrombosis. PROCESS:A compound shown by the formula II [Z is H, OP, CH3, CH2OP (P is H or protecting group removable independently of the reside molecule)] is condesned with a copper complex shown by the formula III to give a compound shown by the formula IV. This compound is then condensed with a compound shown by the form V, the protecting group P is removed, and the ester group is hydrolyzed, to give a compound shown by the formula I .
PURPOSE: A composition containing an ethylacetate extract of sea urchin shells as an effective ingredient which is obtained by extracting and purifying the shells of sea urchin with ethylacetate is provided. Therefore, the composition can be effectively used as an antithrombotic pharmaceutical and food composition against diseases such as hypertension, heart disease, cerebral apoplexy, myocardial infarction, etc. caused by coagulation of thrombus and platelet because the sea urchin shell extract inhibits thrombus formation. CONSTITUTION: The shells of sea urchin are freeze dried, extracted at 20 to 25deg.C for 30 to 120min by a successive solvent extracting method and then purified using guanidium HCl, urea, EDTA, etc., wherein the solvent is hexane, ethylether, ethylacetate, acetone, methanol, water, etc. and the extraction yield thereof is 0.1 to 0.3%. The shell extract of sea urchin shows excellent inhibition activity against in-vitro and in-vivo formation of a thrombus.
BACKGROUND: RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C modification on breast cancer (BC) remains unclear. Our study aims to elucidate the molecular mechanism underlying how NSUN2 regulates the target gene HGH1 (also known as FAM203) through m5C modification, thereby promoting BC progression. Additionally, this study targets at preliminarily clarifying the biological roles of NSUN2 and HGH1 in BC.
METHODS: Tumor and adjacent tissues from 5 BC patients were collected, and the m5C modification target HGH1 in BC was screened through RNA sequencing (RNA-seq) and single-base resolution m5C methylation sequencing (RNA-BisSeq). Methylation RNA immunoprecipitation-qPCR (MeRIP-qPCR) and RNA-binding protein immunoprecipitation-qPCR (RIP-qPCR) confirmed that the methylation molecules NSUN2 and YBX1 specifically recognized and bound to HGH1 through m5C modification. In addition, proteomics, co-immunoprecipitation (co-IP), and Ribosome sequencing (Ribo-Seq) were used to explore the biological role of HGH1 in BC.
RESULTS: As the main m5C methylation molecule, NSUN2 is abnormally overexpressed in BC and increases the overall level of RNA m5C. Knocking down NSUN2 can inhibit BC progression in vitro or in vivo. Combined RNA-seq and RNA-BisSeq analysis identified HGH1 as a potential target of abnormal m5C modifications. We clarified the mechanism by which NSUN2 regulates HGH1 expression through m5C modification, a process that involves interactions with the YBX1 protein, which collectively impacts mRNA stability and protein synthesis. Furthermore, this study is the first to reveal the binding interaction between HGH1 and the translation elongation factor EEF2, providing a comprehensive understanding of its ability to regulate transcript translation efficiency and protein synthesis in BC cells.
CONCLUSIONS: This study preliminarily clarifies the regulatory role of the NSUN2-YBX1-m5C-HGH1 axis from post-transcriptional modification to protein translation, revealing the key role of abnormal RNA m5C modification in BC and suggesting that HGH1 may be a new epigenetic biomarker and potential therapeutic target for BC.
Set-based association analysis is a valuable tool in studying the etiology of complex diseases in genome-wide association studies, as it allows for the joint testing of variants in a region or group. Two common types of single nucleotide polymorphism (SNP)-disease functional models are recognized when evaluating the joint function of a set of SNP: the cumulative weak signal model, in which multiple functional variants with small effects contribute to disease risk, and the dominating strong signal model, in which a few functional variants with large effects contribute to disease risk. However, existing methods have two main limitations that reduce their power. Firstly, they typically only consider one disease-SNP association model, which can result in significant power loss if the model is misspecified. Secondly, they do not account for the high-dimensional nature of SNPs, leading to low power or high false positives. In this study, we propose a solution to these challenges by using a high-dimensional inference procedure that involves simultaneously fitting many SNPs in a regression model. We also propose an omnibus testing procedure that employs a robust and powerful P-value combination method to enhance the power of SNP-set association. Our results from extensive simulation studies and a real data analysis demonstrate that our set-based high-dimensional inference strategy is both flexible and computationally efficient and can substantially improve the power of SNP-set association analysis. Application to a real dataset further demonstrates the utility of the testing strategy.
Prospective, multicenter, single-arm (non-randomized) study. All patients will undergo a run in period on optimal medical therapy as part of eligibility testing. Final determination to initiate treatment will be made after initial airway inspection. A total of 20 patients will be treated. Inflammatory biomarkers (washes and brushes) will be collected in all patients and bronchial biopsies will be collected from the last 10 patients at the time of treatment and at 90-days post-treatment. All patients will be prescribed peri-procedural antibiotics and steroids to minimize procedural risks. All patients will be provided a mobile handheld spirometer to measure and record daily peak expiratory flow both before and after treatment to monitor lung function. Patient follow-up will be conducted out to 3 years.
The invention relates to traditional Chinese medicine for treating cutaneous pruritus. The traditional Chinese medicine comprises, by weight, 10-15 parts of leonurus, 10-12 parts of fructus kochiae, 6-15 parts of Chinese prickly ash, 10-30 parts of radix sophorae flavescentis, 5-15 parts of snake slough, 5-20 parts of fructus cnidii, 10-20 parts of cortex dictamni, 6-15 parts of cuttlebone, 5-20 parts of caltrop, 10-20 parts of astragalus membranaceus and 10-20 parts of wolfiporia extensa. The traditional Chinese medicine has the functions of heat-clearing and damp-drying, sterilization and bacteriostasis, wind-dispelling and itching-arresting, dampness astringing and sore closing, apocenosis and analgesia. A good therapeutical effect on skin itch is achieved. Skin sebum secretion can be balanced, pores are dredged and astringed, and toxins impurities in skin are removed. The growth and repair of damaged blood vessel nerve cells are promoted, and the cell viability of subcutaneous blood capillary is recovered. The traditional Chinese medicine has a good therapeutic effect on skin itch, eczema and prurigo.
Polyps are well-known cancer precursors identified by colonoscopy. However, variability in their size, appearance, and location makes the detection of polyps challenging. Moreover, colonoscopy surveillance and removal of polyps are highly operator-dependent procedures and occur in a highly complex organ topology. There exists a high missed detection rate and incomplete removal of colonic polyps. To assist in clinical procedures and reduce missed rates, automated methods for detecting and segmenting polyps using machine learning have been achieved in past years. However, the major drawback in most of these methods is their ability to generalise to out-of-sample unseen datasets from different centres, populations, modalities, and acquisition systems. To test this hypothesis rigorously, we, together with expert gastroenterologists, curated a multi-centre and multi-population dataset acquired from six different colonoscopy systems and challenged the computational expert teams to develop robust automated detection and segmentation methods in a crowd-sourcing Endoscopic computer vision challenge. This work put forward rigorous generalisability tests and assesses the usability of devised deep learning methods in dynamic and actual clinical colonoscopy procedures. We analyse the results of four top performing teams for the detection task and five top performing teams for the segmentation task. Our analyses demonstrate that the top-ranking teams concentrated mainly on accuracy over the real-time performance required for clinical applicability. We further dissect the devised methods and provide an experiment-based hypothesis that reveals the need for improved generalisability to tackle diversity present in multi-centre datasets and routine clinical procedures.
We conducted the study to assess the effect of patient-tailored diet counseling on the nutritional status of chronic respiratory disease (CRD) patients under the pulmonary rehabilitation program from June 2021-May 2022. These patients completed 2 months of patient-tailored diet counseling sessions under the pulmonary rehabilitation program, which consisted of 4-5 interactive diet counseling sessions fortnightly. The pre- and postassessment was done using standardized outcomes: Malnutrition Universal Screening Tool (MUST), body mass index (BMI), and ideal body weight. The study enrolled 110 CRD patients. There was a statistically significant improvement in pre- and postassessment in MUST score, appetite, and unintentional weight loss (P < 0.001). Most of the patient's BMI normalized. In prenutritional assessment, most of the patients were malnourished and in postassessment, the number of malnourished and anemic patients was reduced. This study concludes that nutritional counseling effectively improves nutritional status and anemia.
A dry powder inhalation device includes a guiding housing, a suction nozzle assembly, a accommodating chamber, an acupuncture assembly and a sliding sleeve. The suction nozzle assembly is disposed on one side of the guiding housing. The accommodating chamber is disposed in the guiding housing, and the accommodating chamber includes a first accommodating part and a second accommodating part. The acupuncture assembly includes an acupuncture and a base. The acupuncture is connected to the base, and part of the acupuncture is located in the first accommodation part of the accommodating chamber. The sliding sleeve is disposed on the opposite side of the guiding housing and is connected to the base of the acupuncture assembly, and the sliding sleeve can move relative to the guiding housing. When the sliding sleeve moves relative to the guiding housing and moves toward the suction nozzle assembly, the sliding sleeve simultaneously drives the base to move toward the suction nozzle assembly, and during the movement of the base, it drives the acupuncture from the first accommodating part to move into the second accommodating part.
Overweight and obesity are leading causes of cardiometabolic dysfunction. Despite extensive investigation, the mechanisms mediating the increase in these conditions are yet to be fully understood. Beyond the endogenous formation of advanced glycation endproducts (AGEs) in overweight and obesity, exogenous sources of AGEs accrue through the heating, production, and consumption of highly processed foods. Evidence from cellular and mouse model systems indicates that the interaction of AGEs with their central cell surface receptor for AGE (RAGE) in adipocytes suppresses energy expenditure and that AGE/RAGE contributes to increased adipose inflammation and processes linked to insulin resistance. In human subjects, the circulating soluble forms of RAGE, which are mutable, may serve as biomarkers of obesity and weight loss. Antagonists of RAGE signalling, through blockade of the interaction of the RAGE cytoplasmic domain with the formin, Diaphanous-1 (DIAPH1), target aberrant RAGE activities in metabolic tissues. This review focuses on the potential roles for AGEs and other RAGE ligands and RAGE/DIAPH1 in the pathogenesis of overweight and obesity and their metabolic consequences.
A multicomponent behavioral intervention to support family caregivers of persons with dementia. The enrollment session (session 0) will be conducted face-to-face. Thereafter, participants will receive 4-6 intervention sessions by phone with either audio or video call over the course of 1-3 months. The sessions will occur every 1-2 weeks depending on the needs and availability of family caregivers.
No intervention is performed. Lung ultrasonography is performed within 4 hours after surgery for diagnostic purpose.
The investigators aim to improve the care of patients (pts) admitted to the Neuroscience Intensive Care Unit (NICU) and their family caregivers (cgs) by conducting a pilot feasibility randomized controlled trial (RCT; N=80 dyads; 60 completers) of the dyadic resiliency program ("Recovering Together") to prevent chronic emotional distress in both pts and their cgs. Eligible dyads include adult, English speaking pts with acute neurological injury (ANI) admitted to the NICU, cleared medically and cognitively for participation by the nursing team, and their primary cgs. Dyads who are randomly assigned to "Recovering Together" will receive 6 manualized sessions (2 in person at hospitalization and 4 through live video after discharge, to reduce burden and facilitate access to care) led by a clinical psychologist. Dyads who are randomly assigned to the attention placebo educational control condition will receive 6 manualized sessions (2 in person and 4 through live video with a clinical psychologist), modeled after the Recovering Together program that will control for the dose of the intervention and support from therapist. Dyads will complete assessment surveys before, after the intervention and 3 months later. Clinical data on demographics, diagnosis, ANI severity, and any medical complications will be extracted from electronic health records.
There has been recent progress in intraoperative fluid therapy. However, little is known about intraoperative fluid therapy in laparoscopic surgery. The purpose of this study is to determine whether there are differences in the basal fluid requirements during surgery between laparotomy and laparoscopic distal pancreatectomy. This study analyzed the records between June 2006 and March 2016. And 253 patients who underwent distal pancreatectomy via either laparotomy (73 patients) or laparoscopy (180 patients). This study was based on a retrospective review and analysis of the electronic medical records. The volume of intraoperative fluid administered, postoperative complications, length of hospital stay, and readmission rate were evaluated. The total volume of fluids was calculated as the sum of the volume of crystalloid plus the volume of colloid multiplied by 1.5 or 2.0.
The invention discloses a method for preparing vitamin D calcium soft capsules. For effectively absorbing calcium, the human body needs to have sufficient vitamin D. Usually, people thick the vitamin D can thick the vitamin D can be completely acquired from sunlight, but the it is not the case in face. Suppose sunscreen cream applied can greatly reduce the generation of vitamin D, vitamin D is basically not generated in parts covered by clothes. Thus, vitamin D shortage is inevitable particularly when females who love beauty are so reluctant to act in sunlight for fear of being black in sunlight. Meanwhile, mineral oil and smoke are also enemies of vitamin D. The formula of the vitamin D calcium soft capsules comprises the following components: 500 grams of calcium carbonate powder, 0.05 gram of vitamin D3, 460 grams of soybean salad oil, 20 grams of soyabean lecithin and 20 grams of beewax. The vitamin D calcium soft capsules are used for supply calcium to human bodies.