anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to Chinese medicine and a preparing method thereof for treating acute or purulent otitis media. The Chinese medicine is composed of 50 to 60% of alum, 20 to 25% of periostracum cicadae and 30 to 15% of coptis according to the compounding ratio of the medicine. A prescription and a making method are simple. The present invention has the advantages that the recipe is a recipe handed down from an ancestor and is used for curing many otitis media patients. The recipe is used for curing the otitis media and has good curative effects on curing stomatocace and inflammation caused by trauma, namely skin ulcers by clinic practice. The medicine is used for only once for an acute disease and is used for two to three times for curing a chronic disease.
<P>PROBLEM TO BE SOLVED: To provide a double-stranded RNA exhibiting an antiproliferative effect specifically to cancer cells, and to provide a medicine.  <P>SOLUTION: The double-stranded RNA is homologous to the fixed target sequence of an anticancer agent target gene and inhibits expression of the anticancer agent target gene by an RNA interference. The target sequence contains a polymorphic site. The anticancer agent target gene is, for example, a thymidylate synthase gene. The polymorphic site is 6 bases each successive at three parts of specific base sequences. The medicine against a cancer contains the double-stranded RNA or vector. The method for designing the double-stranded RNA is provided.  <P>COPYRIGHT: (C)2008,JPO&INPIT
The investigators will recruit and conduct a cross-sectional online survey through ResearchMatch (www.researchmatch.org) with 600 tobacco users across the country. The survey will ask participants for their preferences regarding hypothetical tobacco treatment programs. Participants will be randomized to 12 conditions (n=50 per condition). Each condition has a different combination of treatment options. The survey will also assess sociodemographics and tobacco use behaviors. All participants will be asked if they would like to receive information about the state's smoking cessation quitline. Participants who would like to receive information will be given the 1800-QUIT-NOW number and smokefree.gov website address.
OBJECTIVE: To explore clinical efficacy of proximal femoral nail anti-rotation(PFNA),InterTan and proximal femoral bionic intramedullary nail (PFBN) in treating femoral intertrochanteric fracture.
METHODS: Clinical data of 120 patients with intertrochanteric fracture who were underwent closed reduction intramedullary nail-internal fixation from January 2020 to January 2021 were retrospectively analyzed. According to methods of internal fixation,patients were divided into 3 groups. There were 25 patients in PFBN group,including 16 females and 9 males,aged from 69 to 79 years old with an average of (73.67±5.16) years old. There were 55 patients in PFNA group,including 38 females and 17 males,aged from 68 to 80 years old with an average of (74.23±5.57) years old. There were 40 patients in InterTan group,including 26 females and 14 males,aged from 68 to 79 years old with an average of (73.45±5.34) years old. Operative time,intraoperative blood loss,incision length,hospital stay,weight-bearing time,fracture healing time and complications among 3 groups were compared,and clinical effect was evaluated by Harris score of hip function before operation,1,6 and 12 months after opertaion,respectively.
RESULTS: Patients among 3 groups were successfully completed operation and were followed up for more than 12 months. There were no significant difference in hospital stay,operative time,intraoperative blood loss and incision length among 3 groups (P>0.05). Weight bearing time of PFBN group (7.98±1.34) d and InterTan group (8.22±0.46) d were earlier than that of PFNA group (10.27±0.66) d(P<0.01). Fracture healing time of PFBN group (10.14±2.33) weeks and InterTan group (11.87±2.48) weeks were earlier than that of PFNA group (13.68±2.36) weeks (P<0.01). One month after operation,Harris score in PFBN group (70.52±5.34) and InterTan group (69.81±6.17) was higher than that of PFNA group (51.46±5.36),and there was no significant difference between PFBN group and InterTan group (P>0.05). There were no significant difference in Harris scores among 3 groups before operation,6 and 12 months after opertaion(P>0.05). Cases of complication of InterTan group and PFNA group were lower than that of PFNA group (P<0.05).
CONCLUSION: PFBN and InterTan for the treatment of intertrochanteric fracture have advantages of faster fracture healing,earlier weight-bearing time and fewer postoperative complications than traditional PFNA,but three operations could achieve higher effective rates without significant difference in long-term results.
BACKGROUND: Iatrogenic injury to the infrapatellar branches of saphenous nerve is a common complication following tibial nailing. This lesion seems to be directly related to the surgical approach adopted for nail insertion. The aim of the present study was to systematically review the current literature in order to assess the eventual superiority of one surgical approach for tibial nailing over the others in limiting the neurological impairment related to infrapatellar branch injury.
MATERIALS AND METHODS: The available literature was systematically screened searching papers dealing with iatrogenic injury to the infrapatellar branch of saphenous nerve after intramedullary tibial nailing. The terms "Saphenous" and "Infrapatellar branch" were used in combination with "intramedullary nailing" and "tibial fractures", supplying no limits regarding the publication year. Only publications in English were considered. Case reports, technical notes, instructional course, literature reviews, biomechanical and/ or in vitro studies were all excluded. Coleman methodological score was performed in all the retained articles.
RESULTS: Four articles matched the inclusion criteria. There were one original article and three retrospective study. Hypoesthesia and a larger extension of the area of sensory-loss were more frequently observed after vertical incision approach in three out of four articles. A trend towards a lower rate of iatrogenic nerve damage using a transverse incision was found in the remaining one, without any statistical significance.
CONCLUSIONS: In order to avoid infrapatellar nerve lesion, horizontal or oblique incisions or percutaneous approaches should be favored, although in some cases a longitudinal incision is required. Limited-extension incisions could minimize the risk and the incidence of this complication.
Persons with spinal cord injury (SCI) are at increased risk of developing a Stage III or IV (full-thickness) pressure ulcer (PU). These wounds are associated with a tremendous personal and financial cost. An intervention that proves efficacious in the facilitation of healing this chronic medical condition would be of enormous medical, social, and economic benefit to persons with SCI and other cohorts with a difficult to heal PUs. From preliminary studies, it appears that hypodermoclysis (i.e., an interstitial infusion) with an antibiotic (i.e., cefazolin; a first generation cephalosporin) and subsequent dispersion with ultrasound throughout the wound recently has been shown in preliminary work to be efficacious in the treatment of infection, both recognized pathogenic organisms and those that have colonized the wound bed), which then appears to facilitate wound closure and success of standard surgical intervention. This approach to wound care represents a paradigm shift because previously it was assumed that nonpathogenic organism did not impede wound healing or skin graft survival. The investigators will test this novel approach to wound healing in persons with SCI who have a chronic PU of the pelvic region.
<P>PROBLEM TO BE SOLVED: To provide a sustained release fine particle preparation which uses granulated particles having a high bulk density and inhibiting adhesion and coagulation and has stable solubility, and to provide a method for producing the same.  <P>SOLUTION: The sustained release fine particle preparation is characterized in that theophylline-containing granulated particles prepared by spray-drying a dispersion comprising theophylline, a water-insoluble polymer such as a cellulose derivative or a (meth)acrylate-based polymer, and an aqueous solvent comprising water and a water-soluble organic solvent are coated with the water-insoluble polymer such as the cellulose derivative or the (meth)acrylate-based polymer. The sustained release fine particle preparation does substantially not contain a higher fatty acid glycerol ester. The ratio of the water to the water-soluble organic solvent may be about 100 pts. wt. to about 0.1 to 60 pts. wt.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patients below 60 years in intermediate clinical stages I or II with at least one risk factor are treated with 2 cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) escalated and 2 cycles of ABVD in PET-4 negative cases. Involved site radiotherapy of 30 Gy is indicated in PET-4 positive patients with intermediate stages after chemotherapy.
Coadministration of carbamazepine extended-release capsules with delavirdine may lead to loss of virologic response and possible resistance to delavirdine or to the class of non-nucleoside reverse transcriptase inhibitors (see CONTRAINDICATIONS). 

Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.

Given the anticonvulsant properties of carbamazepine, carbamazepine extended-release capsules may reduce the thyroid function as has been reported with other anticonvulsants. Additionally, anti-malarial drugs, such as chloroquine and mefloquine, may antagonize the activity of carbamazepine. Thus if a patient has been titrated to a stable dosage on one of the agents in this category, and then begins a course of treatment with carbamazepine extended-release capsules, it is reasonable to expect that a dose adjustment may be necessary.

Because of its primary CNS effect, caution should be used when carbamazepine extended-release capsules are taken with other centrally acting drugs and alcohol.
Understanding perturbations in circulating lipid levels that often occur years or decades before clinical symptoms may enhance our understanding of disease mechanisms and provide novel intervention opportunities. Here, we assessed if polygenic scores (PGSs) for complex traits could detect lipid dysfunctions related to the traits and provide new biological insights. We constructed genome-wide PGSs (approximately 1 million genetic variants) for 50 complex traits in 7,169 Finnish individuals with routine clinical lipid profiles and lipidomics measurements (179 lipid species). We identified 678 associations (P < 9.0 × 10-5) involving 26 traits and 142 lipids. Most of these associations were also validated with the actual phenotype measurements where available (89.5% of 181 associations where the trait was available), suggesting that these associations represent early signs of physiological changes of the traits. We detected many known relationships (e.g., PGS for body mass index (BMI) and lysophospholipids, PGS for type 2 diabetes and triacyglycerols) and those that suggested potential target for prevention strategies (e.g., PGS for venous thromboembolism and arachidonic acid). We also found association of PGS for favorable adiposity with increased sphingomyelins levels, suggesting a probable role of sphingomyelins in increased risk for certain disease, e.g., venous thromboembolism as reported previously, in favorable adiposity despite its favorable metabolic effect. Altogether, our study provides a comprehensive characterization of lipidomic alterations in genetic predisposition for a wide range of complex traits. The study also demonstrates potential of PGSs for complex traits to capture early, presymptomatic lipid alterations, highlighting its utility in understanding disease mechanisms and early disease detection.
Radial nerve palsy is associated with serious disability jeopardizing the grasp and power grip accountable to the loss of thumb and fingers extension and loss of active wrist extension respectively. There are three aims in the treatment of radial nerve palsy which comprise the restoration of thumb extension and abduction, finger extension and restoration of wrist extension. In this study we measured the functional outcome after tendon transfer for radial nerve palsy aimed to restore the wrist extension, finger extension and thumb extension/abduction. Investigators' objective was to assess the functional outcome after tendon transfer surgery for radial nerve palsy. So investigators conducted a retrospective study at Aga Khan University Hospital Karachi comprising records of patients operated for irreversible high radial nerve palsy. Investigators concluded that tendon transfer surgery for radial nerve palsy provides excellent results to restore the lost function and therefore must be considered for patients with no signs of recovery after the nerve repair.
Background Crowding and readmissions are common challenges in Emergency departments across Europe. The decision whether to admit or discharge the patient is challenging and is often based on clinical signs and symptoms e.g. blood pressure, pulse, respiratory rate, oxygen saturation and temperature. But some patients are unnecessarily admitted and may have been better off if sent home. Other patients may be discharged without - and one out of five patients are readmitted within a month raising the question whether the patient should have been admitted at first presentation in the ED. suPAR is a strong prognostic biomarker measured routinely in acute medical patients in some emergency department (ED) settings.suPAR is a broadly applicable biomarker of risk, and it has been developed an algorithm for simple interpretation of suPAR in clinical decisions for the study.

Objective To evaluate the use of a clinical decision algorithm in the ED with the aim of improving discharge or admission decisions.
The present invention relates to a traditional Chinese medicine for treating hypertension emergency, which is derived from a clinical empirical prescription. The traditional Chinese medicine is composed of 6 to 15g of buffalo horn, 6 to 12g of tree peony bark, 6 to 15g of cyathula root, 15 to 60g of plaster stone, 10 to 15g of common selfheal fruit-spike, 3 to 12g of radix et rhizoma rhei, 0.2 to 0.5g of calculus bovis, 3 to 10g of tall gastrodis tuber, 15 to 30g of nacre and 10 to 20g of kudzuvine root. A prescription is formed by selecting medicines according to the viewpoints that hypertension emergency is treated from qi and blood and the principles that manifestations are treated in case of emergency, the medicine properties of traditional Chinese medicines are combined with the modern theories of traditional Chinese medicines, etc. The present invention has the main efficacy of removing pathogenic heat from blood, detoxifying toxic material, regulating and tonifying the blood, purging pathogenic fire, lowering adverse-rising energy, ensuring the proper downward flow of blood, dispersing wind, stopping spasmodic cough, tranquilizing mind, promoting urination, expanding blood vessels, lowering blood pressure, etc. Endogenous toxic material refers to liver catharsis and malfunction, the failure of the liver to store blood, the upward invasion of liver-qi, the hyperactivity of liver yang, the hyperpyrexia of the liver, endogenous liver wind and endogenous wind, fire and heat toxic material. The endogenous toxic material causes pyrosyndrome involving both qi and blood, hemopyretic bleeding, the accentuation and even the reverse disorder of qi and blood and the upward invasion of qi and blood, and further causes hypertension emergency. Root causes lie in the liver, and the manifestations lie in the qi and blood. The present invention emphasizes on the treatment of the manifestation, and also treats the root cause. The present invention quickly reverses the.
Provided herein are compounds that react with reactive lipid species to form non-toxic products or active products. Methods of reducing reactive lipid species are also provided. Further provided are methods of treating mitochondria in a patient suffering from mitochondrial dysfunction. In other embodiments, a compound is provided that reacts with an activator present in mitochondria to form an active product that inhibits or enhances opening of Mitochondrial Permeability Transition Pore (MPTP). In further embodiments, methods of inhibiting or enhancing the patency of MPTP are provided. Also provided are non-polar compounds capable of crossing the Blood Brain Barrier (BBB) into the Central Nervous System (CNS).
The mortality of acute renal failure (ARF) remains high despite advances in supportive care. There are no established effective drug therapies, and dialysis may promote renal injury via hypotension or neutrophil activation. Many agents \[e.g., mannitol, furosemide, dopamine, Atrial Natriuretic Peptide (ANP), Insulin-like Growth Factor (IGF-1), thyroid hormone, etc.\] are effective in animal models but ineffective in treating or preventing human ARF. The failure of these agents in human ARF may be due to late enrollment into the trial; effective therapy will likely require earlier detection.

The objective of this clinical study is to identify new biomarkers of renal injury, progression or recovery by analyzing urinary proteins during ARF. We will enroll patients with ARF, patients at high risk of ARF, patients with volume depletion, patients with urinary tract infection, patients with chronic kidney disease, and normal subjects. The diagnosis of pre-renal versus renal ARF will be made by routine clinical and laboratory testing. The level of renal dysfunction will be determined by creatinine clearance. Those patients at high risk for ARF will be followed prospectively and will undergo additional testing if ARF does develop. Patients will also be studied after creatinine levels return to normal. We will identify protein and/or microRNA biomarkers that are unique to patients with ARF,but not found in normal subjects or patients with volume depletion. It is hoped that some of these proteins may form the basis of new diagnostic tests for ARF.
The present invention relates to a preparing method of a natural anti-ageing preparation and a technology thereof. The existing anti-ageing preparation has various varieties, but lacks of obviously strengthening curative effect. The natural anti-ageing preparation aims to develop the natural anti-ageing preparation which has peculiarly and obviously strengthening curative effects by using the medical heritage of China. The natural anti-ageing preparation is mainly prepared from yunnan rhodiola, animal brain tissue, mineral water, urina hominis, baby's lanugo hair charcoal, glucose, etc. for regulating functions of each large system of a human body. The natural anti-ageing preparation has the characteristics of disease prevention, cure of disease and rejuvenation, and has the advantages of little investment, obvious effect and wide prospects.
Patients with Chronic Obstructive Pulmonary Disease with Chronic Bronchitis will be randomized in a 1:1 ratio to receive GDC-6599 or placebo for 14 days during the first study period (Treatment Period 1, Study Visits 2-4). Following a 14-day washout period, patients will cross over to the second study period (Treatment Period 2, Study Visits 5-7) and will receive the alternate treatment (GDC-6599 or placebo) for 14 days starting at Study Visit 5.
BACKGROUND: Surgical site infection (SSI) is not rare after loop ileostomy reversal. This study assessed the effects of a subcutaneous closed suction drain on reducing SSIs after loop ileostomy reversal with purse-string skin closure.
METHODS: This retrospective study included 229 patients who underwent loop ileostomy reversal with purse-string closure at the Pusan National University Yangsan Hospital between January 2017 and December 2021. We divided the patients into those with a subcutaneous drain (SD group) and those without it (ND group). We analyzed variables that affected SSI occurrence in both groups.
RESULTS: The SD and ND groups included 109 and 120 patients, respectively. The number of incisional SSIs was significantly lower in the SD than in the ND group (0 vs. 7 events). An average of 35.7 mL of fluid was collected in the drainage bulb during hospitalization. The C-reactive protein level on postoperative day 4 was significantly lower in the SD group than in the ND group. The insertion of a subcutaneous drain was the only factor associated with a reduced incidence of SSIs (p = 0.015).
CONCLUSIONS: Subcutaneous closed suction drain with purse-string skin closure in loop ileostomy reversal can reduce incisional SSI occurrence.
Recruitment of 100 healthy controls (HC) by public announcements (i.e. advertisement/flyer) on the University Hospital's and the University's notice board.
In the end of the surgery, gradual withdrawal of remifentanil was prescribed until the endotracheal tube was extubated. Following by drip-infusion of remifentanil for 30 minutes was administered immediately after tracheal extubation.
Secretory diarrhea has many causes as infection with bacteria, viruses or protozoa. It results from increased chloride secretion, decreased sodium absorption, or increased mucosal permeability . Parasitic pathogens induce Secretory diarrhea as they infect and damage the absorptive villus tips, leaving Secretory crypts unbalanced, to cause net secretion and diarrhea. Parasitic causes include Cryptosporidium parvum or hominis ,Capillaria philippinensis and Giardia lamblia. Cryptosporidiosis is also recognized as a cause of prolonged and persistent diarrhea in children and persons with impaired immunity. The disease is transmitted via the fecal-oral route from infected hosts. It can be also transmitted following animal contact, ingestion of water (mainly during swimming), or through food. Cryptosporidium has emerged as the most frequently recognized cause of water-associated outbreaks of gastroenteritis. This is because of the oocyst stage in its life cycle; Cryptosporidium can resist disinfection, including chlorination, and can survive for a prolonged period in the environment.
<P>PROBLEM TO BE SOLVED: To modulate effect of GDF-8 on a cell.  <P>SOLUTION: Provided is a use of a protein, GASP1, comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, it relates to the use of GASP1 for treating disorders that are related to modulation of the level or activity of GDF-8. It is useful for treating muscular disorders and diseases, particularly those in which an increase in muscle tissue is therapeutically beneficial. It is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Participants who have completed the double-blind period will be eligible to receive mitapivat for up to 5 years in the OLE period. Participants entering the OLE period will first receive blinded mitapivat and placebo for 8 weeks to maintain the double-blind treatment assignment before being transitioned to only receive active, open-label drug (mitapivat).