anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The subject of the course is Mind/Body medicine. This course is learning about the mind and the body through lectures. The course will meet once every week, for a total of 8 weeks, for roughly 2 hours per class. You will be provided with a schedule of the weekly classes, which will occur on the same day every week, at the same time. Weekly sessions will be run by a teacher and will include other participants in the class. You will also be given homework assignments that are intended to reinforce what you learn in the program. The assignments will require up to 45 minutes, 6 days/week. Following the 6th class, and before the 7th class, there is a voluntary all day Saturday program. Participation in this program is optional. You are expected to continue to incorporate what you learned in the class in your daily routine after you are done with the classes.
The invention belongs to the technical field of medicine and in particular relates to a traditional Chinese medicine composition for treating mind confusion type hyperthyroidism combined nodal tachycardia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 4 to 8 parts of finelydivided phtheirospermum, 4 to 8 parts of rhizoma angiopleris officinalis, 4 to 8 parts of vernonia parishii hook, 4 to 8 parts of vernonia parishii Hook. f, 4 to 8 parts of triplostegia glandulifera Wall. ex DC., 4 to 8 parts of satyrium henryi schlecht tuber, 4 to 8 parts of citrus aurantium, 4 to 8 parts of cyperus rotundus, 4 to 8 parts of calastrus flagellaris rupr, 4 to 8 parts of ziziphora clinopodioides lam and 4 to 8 parts of radix glycyrrhizae. All the drugs are combined to have the effects of nourishing heart and tranquilizing mind, and promoting qi and resolving stagnation. The traditional Chinese medicine composition has the effects of lowering average heart rate, converting sinus rhythm and recovering a thyroid function level.
Musculoskeletal ageing is an inevitable process associated with profound morphological and functional changes that will ultimately transition an individual from independent, to dependable living, relying heavily on personal health care for survival. The United Kingdom (UK) population aged over 65 years is expected to rise from 8.8 to 11.3 million by 2025. As life expectancy increases due to advances in medical treatment, an age-related disease termed sarcopenia, has become more prevalent in the elderly. Sarcopenia, described as the loss of musculoskeletal mass, strength and/or physical functioning with age, manifests after the 6th decade and rapidly increases after the 8th decade, resulting in a deterioration of health status and quality of life. To manage the looming health and economic consequences of sarcopenia, suitable therapeutic strategies to manage the condition are warranted. Therefore, this randomised control trial (RCT) will investigate the effects of 16-weeks of exercise and nutritional interventions in inactive senior citizens (60 - 90 years old).
<P>PROBLEM TO BE SOLVED: To provide an anti-aging agent containing a natural extract and having excellent safety, a laminin 5 production promoter, an agent for damage recovery action by ultraviolet (UV-B) irradiation, an I type collagen production promoter, a profilaggrin production promoter, a filaggrin production promoter or a skin cosmetic.  <P>SOLUTION: The anti-aging agent includes an extract from Caragana korshinskii and/or Camellia oleifera as an active ingredient. The laminin 5 production promoter, or the agent for damage recovery action by ultraviolet (UV-B) irradiation includes an extract from Caragana korshinskii as an active ingredient. The I type collagen production promoter, the profilaggrin production promoter or the filaggrin production promoter includes an extract from Camellia oleifera as an active ingredient. The skin cosmetic includes an extract from Caragana korshinskii and/or Camellia oleifera.  <P>COPYRIGHT: (C)2010,JPO&INPIT
The subjects in this arm will receive Cyclophosphamide 300mg/m2/d and Fludarabine 30mg/m2/d d-4\~-2. Then anti- MESO CAR-T cells will be injected by a dose of 5×106/kg once at d1(rang from d1-3).
FIELD: virology. SUBSTANCE: african equine plague virus is grown in cell culture or organ animal tissue. Virus-containing suspension is frozen once at -40 C, thawed out at the room temperature and cleared by centrifugation at 3000 rev/min for 20 min. Supernatant is controlled for activity and specificity for reaction of long boudiny of complement. Then virus is inactivated by methylenebismorpholine addition at the final concentration 0.1-0.2% for 48-72 hr at 36-38 C at periodic stirring. After inactivation antigen with titer in reaction of long boudiny of complement 1:8 is concentrated with 4% polyethylene glycol of molecular mass 6000-20000 Da by 35-100 fold and used for donor immunization of specific sera or as diagnostic antigen after preserving with sodium azide 1:5000 or lyophilic drying. EFFECT: improved method of antigen preparing. 3 tbl
In the RAT group, it was planned to perform robotic rehabilitation with a hand-finger robot \[Amadeo (Tyromotion, Graz, Austria)\] for 30 minutes for both upper extremities, accompanied by a physiotherapist who is trained in robotic rehabilitation and has at least 5 years of experience. In robotic rehabilitation, continuous passive range of motion (CPM), active assistive exercises and assistive continuous passive range of motion (CPM Plus) programs will be used.
During extensive periods without rain, known as dry-downs, decreasing soil moisture (SM) induces plant water stress at the point when it limits evapotranspiration, defining a critical SM threshold (θcrit). Better quantification of θcrit is needed for improving future projections of climate and water resources, food production, and ecosystem vulnerability. Here, we combine systematic satellite observations of the diurnal amplitude of land surface temperature (dLST) and SM during dry-downs, corroborated by in-situ data from flux towers, to generate the observation-based global map of θcrit. We find an average global θcrit of 0.19 m3/m3, varying from 0.12 m3/m3 in arid ecosystems to 0.26 m3/m3 in humid ecosystems. θcrit simulated by Earth System Models is overestimated in dry areas and underestimated in wet areas. The global observed pattern of θcrit reflects plant adaptation to soil available water and atmospheric demand. Using explainable machine learning, we show that aridity index, leaf area and soil texture are the most influential drivers. Moreover, we show that the annual fraction of days with water stress, when SM stays below θcrit, has increased in the past four decades. Our results have important implications for understanding the inception of water stress in models and identifying SM tipping points.
Group B will receive hot packs along with Hip abductors strengthening. A baseline assessment will be done on eligible participants. 3 sessions were given 3 days per week, Outcome measures will be taken at baseline, in 3rd week, and at the end of the 6th week.
Rheumatism treating nectar is special effect nutritional wine developed according to a modern traditional Chinese and western medicine combination theory and used for strengthening human body adaptability, restraining immunoreactions, resisting inflammation and irritability, resisting rheumatism and opening up meridians. The rheumatism treating nectar is suitable for being drunk by patients suffering chronic cold allergic and immune rhinitis, rheumatism, rheumatoid, intermittent headache, vasculitis, angiitis, arthritis, nephritis, urticaria, dermatitis and the like. The technical scheme for solving the technical problem is that traditional Chinese medicine for strengthening human body adaptability, restraining immunoreactions, resisting inflammation and irritability, resisting rheumatism and opening up meridians, white spirit and white granulated sugar are adopted in a formula theory according to etiology and pathology of chronic cold anaphylaxis and immune diseases of a human body. A formula specifically consists of the white spirit, eucommia ulmoides, negundo chastetree fruits, cortex acanthopanacis, radix clematidis, evergreen mucuna roots and leaves, suberect spatholobus stems, bighead atractylodes rhizome, codonopsis pilosula, liquorice, cuttle bones and the white granulated sugar. The traditional Chinese medicine is smashed in the production process and is manufactured into bottled edible nutritional wine by means of a modern wine production technology. Habits of Chinese traditional wine culture are preserved, and a traditional Chinese and western medicine combination theory combining the rheumatism treating nectar name and etiology and pathology and clinical effects of chronic cold anaphylaxis and immune diseases, and a modern novel mechanical wine manufacture technical characteristics are further embodied.
1,144,225. Medicinal capsules. DOW CHEMICAL CO. 2 Sept., 1966 [7 Sept., 1965(2)], No. 38397/66. Heading B8C. [Also in Division C3] A process for preparing medicinal capsules from hydroxyalkyl-alkyi cellulose ethers comprises forming them from a solution having an operational viscosity of 1000-4,500 cps. and comprising (1) 10-30 weight per cent of a water soluble C 2 -C 4  hydroxyalkyl-alkyl cellulose ether which has a C 2 -C 4  hydroxyalkoxyl content of 4-15 weight per cent, a C 1 -C 2  alkoxyl content of 18-32 weight per cent and a capillary viscosity of 2-20 cps. as a 2 weight per cent solution in water at 20 C. and (2) an aqueous solvent. The former consists of 15-100 weight per cent water and from 0-85 per cent C 1 -C 3  alcohol; the latter of 15-50 weight per cent of a C 1 -C 3  alcohol and 85-50 weight per cent either of a C 1 -C 3  chlorinated aliphatic hydrocarbon or a C 6 -C 7  aromatic hydrocarbon and not more than 4 weight per cent water. An example of solvent is a mixture of methanol and methylene chloride, or of water and methanol or isopropanol. The capsule forming material may be hydroxypropyl methyl cellulose. Pigment e.g. charcoal or titanium dioxide and/or dyes may be added. Also may be added plasticizers such as glycerine or propylene glycol. The capsules are prepared by dipping conventional pins in the solution, withdrawing them and rotating them during formation of a non-flowing film after which drying may be achieved in a warm air oven.
BACKGROUND AND OBJECTIVES: This study aimed to determine the frequency of laparoscopic inguinal hernia repair (LIHR) and how surgeons managed complications such as intraoperative bleeding, organ damage, and peritoneal injury that may develop during this procedure.
METHODS: The data for the study were collected through an electronic survey created using Google Forms and sent using WhatsApp in May 2024.
RESULTS: The study included 220 of 250 surgeons (88%) working in 25 healthcare centers located in different regions where the survey was distributed. Fourteen respondents with missing data were excluded from the study. The mean age of the remaining 206 participants was 39.6 (27-69) years. The rate of surgeons using laparoscopic techniques in inguinal hernia surgery was 89.3%. The method most preferred by the surgeons performing LIHR was total extraperitoneal (TEP) repair (60.9%), followed by transabdominal preperitoneal (TAPP) repair (39.1%). The surgeons preferred open procedures in patients with a history of lower abdominal surgery, those with scrotal hernia, and elderly patients. Additionally, in cases of intraoperative complications that developed at different stages of TEP, it was observed that participants mostly convert to the TAPP technique (43.5-46%), and in some cases, almost all participants continued the procedure with the same technique, i.e., TEP repair (94.6%).
CONCLUSION: This study revealed that surgeons preferred open procedures in some specific patient groups, but they mostly preferred LIHR in the remaining cases. Young surgeons, in particular, seem more inclined to employ laparoscopic methods. In cases of intraoperative complications, most surgeons chose to continue with laparoscopic techniques.
The purpose of the study is to examine the effectiveness of the Headspace Health Sleep Program for improving both subjective sleep quality (i.e., self-reported surveys) as well as objective sleep quality (i.e. actigraphy) in a population with sleep disturbances. The study will employ a 2-arm app-based intervention involving 1 active intervention (i.e., Headspace Health Sleep Program) and a waitlist control for a duration of 18 days.

A set of outcome measures will be used to evaluate the Headspace Health Sleep Program vs. a waitlist control group. The Insomnia Severity Index (ISI) will be used as a primary outcome measure as well as the Sleep Diary, and actigraphy. In addition, secondary outcome measures include Pittsburgh Sleep Quality Index (PSQI), Perceived Stress Scale (PSS-10), Patient Health Questionnaire-8 (PHQ-8), General Anxiety Disorder-7 (GAD-7) and Mindful Attention Awareness Scale (MAAS). Baseline measures will be taken prior to randomization, and at post-intervention. 2 weeks following the post-intervention assessment, participants will again be asked to report sleep quality using self-reported surveys.

Eligible participants will complete a 1-week baseline assessment period. Participants will be supplied with a wrist actigraph and sleep diary. On the first day of the assessment period, participants will be instructed to start wearing the wrist actigraph. They will also be instructed to complete the sleep diary the following morning. Participants will continue this procedure of filling in the sleep diary every morning for the 1-week baseline assessment period and wearing the wrist actigraph. Following the 1-week baseline assessment period, participants will be asked to return the sleep diary, wrist actigraph, and complete baseline questionnaires (i.e., ISI, PSQI, PSS-10, PHQ8, GAD7, MAAS). They will then be randomized into one of two groups (Headspace Health Sleep Program or waitlist control). Having completed the intervention, participants will be scheduled for the 1-week post-intervention assessment period. Participants will again be supplied with a wrist actigraph, and sleep diary. At the end of this 1-week post-intervention assessment period, participants will return the sleep diary, wrist actigraph, and complete questionnaires (i.e., ISI, PSQI, PSS-10, PHQ8, GAD7, MAAS). 2 weeks following the post-intervention, participants will be asked to complete the sleep diary for a 1-week follow-up assessment period and in addition the ISI, PSQI, PSS-10, PHQ8, GAD7 and MAAS.
The participants will be divided to 2 groups of 50 each. One group will receive 5 days period of 20 min 2mA tDCS over the lt M1 and the other will receive sham stimulation. X week later the groups will switch to the other arm.
Patients undergo RT 5 days a week for 6 weeks and receive vorinostat at the maximum-tolerated dose determined in the feasibility study. Patients receive Maintenance therapy of bevacizumab 10mg/kg/dose every 2 weeks and temozolomide 200 mg/m2/dose Days 1-5, for up to twelve cycles in the absence of progressive disease and unacceptable toxicities.
BACKGROUND: 1,25(OH)2D3 is a fat-soluble vitamin, involved in regulating Ca2+ homeostasis in the body. Its storage in adipose tissue depends on the fat content of the body. Obesity is the result of abnormal lipid deposition due to the prolonged positive energy balance and increases the risk of several cancer types. Furthermore, it has been associated with vitamin D deficiency and defined as a low 25(OH)2D3 blood level. In addition, 1,25(OH)2D3 plays vital roles in Ca2+-Pi and glucose metabolism in the adipocytes of obese individuals and regulates the expressions of adipogenesis-associated genes in mature adipocytes.
SCOPE AND APPROACH: The present contribution focused on the VDR mediated mechanisms interconnecting the obese condition and cancer proliferation due to 1,25(OH)2D3-deficiency in humans. This contribution also summarizes the identification and development of molecular targets for VDR-targeted drug discovery.
KEY FINDINGS AND CONCLUSIONS: Several studies have revealed that cancer development in a background of 1,25(OH)2D3 deficient obesity involves the VDR gene. Moreover, 1,25(OH)2D3 is also known to influence several cellular processes, including differentiation, proliferation, and adhesion. The multifaceted physiology of obesity has improved our understanding of the cancer therapeutic targets. However, currently available anti-cancer drugs are notorious for their side effects, which have raised safety issues. Thus, there is interest in developing 1,25(OH)2D3-based therapies without any side effects.
This retrospective controlled study conducted by Obstetrics and Gynecology clinics of Kayseri Training and Research Hospital.Pregnant women who delivered at the Kayseri Education and Training Hospital of Medicine, in Turkey, between January 2010 and September 2016 were identified.This study was carried out with two groups. The study group consisted of women hospitalized for Hyperemesis gravidarum (HEG) during first trimester of their pregnancy, whereas the control group included all other women who delivered in the same period.Screening for GDM was performed twice during pregnancy. The first screening was performed during the first trimester using the random plasma glucose test with a cutoff value of 109 mg/dl. Screening for GDM was performed for all women during their first prenatal visit, regardless of the presence or absence of hyperemesis-associated symptoms.The second screening was performed during the second trimester, between 24 and 27 weeks, using a 75-g oral glucose tolerance test (OGTT), after pregnant women with HEG got rid of hyperemesis. GDM was diagnosed on the basis of the universal criteria established by the International Association of Diabetes and Pregnancy Study Group: a plasma glucose level that met or exceeded the fasting cutoff value 92 mg/dl, the first-hour cutoff value 180 mg/dl, or the second-hour cutoff value 153mg/dl.

To be considered for diagnosis of pre-gestational diabetes mellitus, women had to meet at least one of the following criteria: the fasting plasma glucose test with a cutoff value of 126 mg/dl or the random plasma glucose test with a cutoff value of 200 mg/dl or the second-hour cutoff value 153mg/dl after 75 gram OGGT (American Diabetes Association) The delivery midwifery and medical records were retrospectively evaluated. All of the patient's body mass index (BMI,calculated as weight in kilograms divided by the square of height in meters), urine ketone levels and ages were recorded separately both in the initial exam and during performing 75 gram OGTT.
TEW-7197 100mg will be administered orally once a day 5days and rest 2days. Study treatment will be continued until objective disease progression.
Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl- cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl- cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
The present invention provides a magnetic nano composite for inhibition/treatment of tumor and method for preparing the same. The magnetic nano composite uses Fe3O4 magnetic nano particles as nuclei, a carboxylated polyaniline as a shell layer, and an anti-cancer drug fixed on the outside of shell layer. The invented method of preparation not only is simple and fast, but also capable of prolonging the half-life of drug and increasing the activity of drug. Furthermore, the thermal stability and storage stability of the anti-cancer drug can be significantly improved, and a drug insoluble in aqueous solution can be uniformly dispersed in an aqueous solution. As a result, the side-effect of rejection in an organism is reduced. Furthermore, a magnetic field can be guided to a diseased part for increasing the local concentration of drug, thereby achieving an objective of centralized treatment. Hence, the present invention has a high commercial value.
The invention relates to a preparation method of enemas for gynecological inflammation, which comprises the following steps. Firstly, select a plurality of pharmaceutical ingredients in weight ratio-sixty shares of red peony root, one hundred shares of rhizome smilacis glabrae, sixty shares of rhizoma sparganii, sixty shares of Szechwan chinaberry fruit, sixty shares of rhizome zedoariae, sixty shares of rhizome corydalis, one hundred shares of fried foxnut, one hundred shares of Chinese angelica, sixty shares of light yellow sophora root, forty shares of nutgrass galingale rhizome, sixty shares of amur corktree bark, one hundred shares of Danshen root, and one hundred and twenty shares of Chinese yam. Secondly, grind the rhizome zedoariae and the Chinese yam into fine powder of forty to one hundred meshes for future use, and decoct the rest medicinal herbs with water for three times: at the first time, add water by five to twenty times in weight and decoct for two hours; at the second time, add water by five to twenty times in weight and decoct for one hour; at the third time, add water by five to twenty times in weight and decoct for one hour, and then mix the three decoction solutions and get the filtrate after filtering. Thirdly, concentrate the filtrate. And finally add the fine powder of the rhizome zedoariae and the Chinese yam into the concentrated filtrate to sterilize, cool down and the enema is made. The preparation method can increase the active ingredients of the medicine remarkably, and the medicine combination in the preparation method is characterized in high content of crude drug, and a fast but good therapeutic effect.