anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Intervention with diaphragmatic breathing exercises will take place in the last 15 minutes of Physical Education classes, focusing on diaphragmatic breathing. This breathing is also characterized by reducing the respiratory cycle or rate, and it can use the count of seconds in a progressive way, either in the inhalation through the nose while the abdomen expands, in the support or blockage or also called pause, and finally in the expiration, also performed by the nostrils. The creation of an inhalation and exhalation pattern becomes important as it has a direct relationship with the reduction of the activities of the sympathetic nervous system and the increase of the activity of the parasympathetic nervous system, also influencing the motor activities, the brain mass, the quality of the sleep and the attenuation of stressors.
Patients receive abiraterone acetate PO QD on days 1-21, prednisone PO BID on days 1-21. Courses of abiraterone acetate and prednisone repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients receive cabazitaxel IV over 1 hour on day 1, and treatment with cabazitaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive standard of care antiandrogen therapy with either LHRH agonist or antagonist, or surgical castration with bilateral orchiectomy.
A GPS tracker will be placed on the wheelchairs of 25 individuals who consent to participate in this arm of the project. Using a GPS tracker will provide a direct measure of the community locations these participants go. The GPS location is collected every minute, and mapped to Google Maps, which would allow calculation of speed of movement.
<P>PROBLEM TO BE SOLVED: To provide a vector forming a nucleic acid as an aggregate, arranging the vector containing a cationic polymer around the aggregate, protecting the nucleic acid from an enzyme, making the vector itself visualizable with fluorescence and visualizing a polyplex.  <P>SOLUTION: The vector is obtained by introducing a fluorescent substance into the terminals of branched chains in the vector composed of a polymer having the cationic branched chains. In the vector, the 3, 4 or 6 branched chains are preferably bound to the benzene ring. The more the number of the branched chains is, the more preferable. The branched chains are preferably a vinylic acrylic polymer. An o-phthalaldehyde derivative etc., can be used as the fluorescent substance to be introduced into the branched chains.  <P>COPYRIGHT: (C)2008,JPO&INPIT
This study involves using a novel computational task (the volatility task, designed by Dr Michael Browning) to examine differences in adaptive learning in terms of sensitivity to environmental change in those who are in eating disorder 'risk' groups (defined as those with a previous diagnosis of AN, and those who score highly in the EAT-26 for eating disorder symptoms. This study allows us to investigate whether or not these individuals are able to pick up key environmental statistics and adapt their behaviour accordingly. We hypothesise that those in eating disorder risk groups will show a deficit in this area, which might begin to explain why the cognitive phenotype of 'cognitive inflexibility' is found so commonly in these patients. Using pupillometry measures will also allow us to putatively form links between this behaviour and the norepinephrine system in these participants, as pupil dilation measures are thought to track environmental statistics of this kind. Additionally, this task allows us to identify whether there is a particular deficit in tracking and learning about positive or negative environmental information. We will be using standard clinical interviews and questionnaires to define the groups and to record key variables (e.g. mood information) within groups. This study will consist of a single visit, including these interviews and questionnaires, the volatility task with pupillometry measures, and the Wisconsin Card Sort Task, which we hope to use to demonstrate a baseline difference between groups on cognitive flexibility.
Investigational drug quarter dose strength (acetaminophen125mg + Ibuprofen 37.5mg) i.e. 2 tablets equating to ¼ the dose in the standard investigational drug.
The invention relates to agents for dyeing keratinic fibers. Said agents contain at least one oxidizable coupling component while being virtually free of developer-type components. The inventive coupling components carry no hydroxy groups or optionally substituted amino groups that are in ortho or para position relative to an optionally substituted amino group. Aromatic compounds that are selected among the group comprising m-phenylenediamine derivatives, m-aminophenol derivatives, quinoline derivatives, pyridine derivatives, and tri(C1-C6)-alkoxyphenol derivatives are used as a coupling component. Surprisingly, keratinic fibers can be oxidatively dyed without utilizing the aromatic compounds that contain amino groups in para position  and are known as being allergenic. The properties of the obtained dyes can be improved by additionally using oxidation activators.
Patients receive ONY-P1 vaccine with BCG intradermally on days 1 and 15. Patients then receive ONY-P1 vaccine alone on day 29 and then every 4 weeks for up to 12 months in the absence of disease progression or unacceptable toxicity.
A smart patch includes a computing device to monitor user health metrics. The smart patch also includes an adhesive coupled to a cradle with an opening and coupled to at least two electrodes capable of electrically coupling to the user. The computing device contains one or more sensors, a battery and a sensor window. The sensors are configured to interface with the user to generate physiological data associated with the user's health. The battery is configured to power the sensors. The computing device is removably coupled to the cradle. The cradle is configured to engage the computing device securing the computing device to the adhesive. The electrodes electrically couple to the user's skin and conduct electrical signals between the user and the computing device.
Participants do an initial call for baseline data. Then the active assessment period (pre / post dietary change) begins. Pre - dietary change procedure is 5 days of standard high HP diet while completing daily electronic assessments of withdrawal, ecological momentary assessments, and a phone appointment. Post - dietary change is 5 days of lower HP diet (food provided for 3 of 5 days) while completing daily electronic assessments of withdrawal, ecological momentary assessments, and a phone appointment. Daily assessments of affect, craving, and withdrawal are all virtual. On day 4-5 of post assessment, participants complete a food journal to report foods they ate to ensure compliance to low HP food diet. The pre / post-dietary change phone appointments include 1) psychosocial stress task, 2) cue reactivity task, 3) questionnaires 4) self-reported weight. Participants may also complete a follow up period of questionnaires every other day and self-report weight at the end of follow up.
The investigators will implement the pancreaticoduodenectomy using the standard lymphadenectomy. The lymph node include 5,6,8a,12b1,12b2,12c,12a-b,14a-b,17a-b of the abdominal lymph node.
Participants are randomized to receive household and personal cleaning products from one of 2 arms: products that either do not contain triclosan or that may contain triclosan. Participants select products from an arm-specific list of commercially available items.
FIELD: medicine, otorhinolaryngology. SUBSTANCE: method is carried out by administration of staphylococcus anatoxin in one of tonsile. This route of immune preparation administration increases its contact with organism immune system and shows favorable action on local and total process course. Method can be used in surgery and therapy for conservative treatment of chronic tonsillitis and other inflammatory diseases of otorhinolaryngology organs. EFFECT: enhanced effectiveness of treatment. 1 tbl
Artificial salivary gland devices and assemblies are provided. The present disclosure provides artificial salivary pump/gland devices and assemblies, and related methods of use. One embodiment utilizes the interstitial/marrow fluid reservoir within the underlying mandibular or maxillary bone as a source for replacement saliva. The salivary pump/assembly, which is implantable in the mandibular or maxillary bone as a dental implant and driven by incidental tooth contact and masticatory forces, harvests interstitial/marrow fluid and treats it via semi-permeable membrane technology and soluble particles as a continuously available saliva replacement. Masticatory forces and tooth contact power the pump to both harvest interstitial/marrow fluid and drive flow through a bed of ion-exchange resins and/or soluble particles to adjust fluid chemistry providing a continuously available saliva-like solution. Exemplary devices and assemblies can also be utilized to introduce beneficial bacteria into the oral cavity and/or be utilized as a delivery system for drugs/therapeutic agents.
A mesembrine alkaloid for use in the treatment of diseases and conditions associated with anxiety and/or mood disorders, is provided. Preferably the mesembrine alkaloid is mesembrenol and/or mesembranol. The diseases or conditions associated with anxiety and/or mood disorders are preferably selected from the group including: generalised anxiety disorder, panic disorder, social anxiety disorder, phobia related disorder, major depressive disorder (MDD) or clinical depression, bipolar I disorder or manic depression, bipolar II disorder or hypomania, cyclothymic disorder, bipolar and related disorder due to another medical condition, depressive disorder due to another medical condition, substance or medication induced bipolar disorder, substance or medication induced depressive disorder, disruptive mood dysregulation disorder, persistent depressive disorder, and premenstrual dysphoric disorder. The disease or condition associated with anxiety and/or mood disorders is preferably treatment resistant. Preferably the mesembrine alkaloid is administered as a single dose or multiple daily doses preferably comprising at least 0.001mg of the mesembrine alkaloid. The mesembrine alkaloid is for improving symptoms associated with anxiety and/or mood disorders, or a disorder where anxiety and/or depression are comorbid.
This review aims to provide hospitalists with a streamlined understanding of the evaluation of syncope, a commonly encountered complaint in hospital medicine. Authors conducted a literature review using the keyword 'syncope' to compile current evidence and recommendations regarding the categorization, risk stratification, and diagnostic evaluation of syncope. The review outlines the categorization of syncope into cardiac, neurally mediated, and orthostatic types, detailing the clinical features, etiologies, and differential diagnoses of each. It provides a structured framework for history-taking, physical examination, orthostatic vital sign assessment, and risk stratification to guide clinicians in efficiently identifying high-risk patients requiring urgent intervention. Additionally, diagnostic modalities including electrocardiography, echocardiography, and point-of-care ultrasound are discussed, along with their respective indications and limitations. By embracing standardized approaches and evidence-based practices outlined in this review, hospitalists can optimize resource utilization, streamline patient care, and improve outcomes in patients presenting with syncope.
### Teratogenic Effects

Pregnancy category C: Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels.

Betamethasone dipropionate has been shown to be teratogenic in rabbits when given by the intramuscular route at doses of 0.05 mg/kg. This dose is approximately 0.03 fold the estimated maximum human dose based on a mg/m2 comparison. The abnormalities observed included umbilical hernias, cephalocele and cleft palates.

Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.
The invention belongs to the technical field of Chinese herbal medicine atomized products, and discloses a Chinese eaglewood sleep-aiding herbal atomized composition and a preparation method and application thereof. The composition is prepared from pure plant Chinese herbal medicines. The medicine mainly takes sweet taste, neutral nature, spleen, lung, stomach and kidney meridians as the medicine channels. The lucid ganoderma has the effects of tonifying qi and soothing nerves; gastrodia elata has the effect of calming liver-yang; flos Caryophylli has effects of warming middle-jiao and tonifying yang; dark plum fruit has the effects of astringing lung and relieving cough; hyacinth dolichos flower has the functions of strengthening spleen and stomach; the jujube kernel can nourish heart and calm mind; the bunge cherry seeds can expel qi and promote urination; herba Moslae can resolve dampness and regulate the middle warmer; rhizoma Polygonati has effects of invigorating spleen and replenishing qi; american ginseng tonifies qi and nourishes yin. The above formula is an integral formula, and after compatibility, the formula is helpful for soothing the nerves, helping sleep, nourishing the heart, benefiting the liver, tonifying qi, nourishing yin, warming the middle-jiao and eliminating dampness. The preparation method reduces the loss of effective components, avoids the influence on the effective components in the raw material treatment, and is easy to store the extract. The distillation can purify the effective components in the extract again, so as to ensure the quality of the product, the purification process also has the sterilization effect, and the use fragrance of the composition is improved.
PROBLEM TO BE SOLVED: To obtain the subject composition, having excellent sustainability and water resistance, capable of producing coating films which give comfortability and useful for makeup or skin care for keratinous matter, by including an aqueous dispersion containing film-forming polymer particles and specific polyorganosiloxane particles. SOLUTION: This composition is obtained by including (A) an aqueous suspension of elastomeric polyorganosiloxane particles which is a partially crosslinked solid, [e.g. BY 29-122 (trade name) (Dow-Corning Toray Co. Ltd.)], and (B) an aqueous dispersion of particles of a film-forming polymer (e.g. polyvinylpyrrolidone copolymer). The component A is obtained by an addition reaction and crosslinking reaction between a poly-organosiloxane such as polydimethylsiloxane and an organosiloxane containing at least one H bound to Si per molecule in the presence of a catalyst. It is desirable that the particle diameter of the polymer in the component A is 0.1-500 μm, and the solid content of the component A is 0.5-65 wt.%.
The present invention makes use of Chinese herbal medicine such as radix astragali 30g, codonopsis pilosula 30g, Chinese stractylodes 15g, fruit of Chinese magnoliavine 15g, rhizoma anemarrhenae 15g, fruit of the Chinese wolfberry 20g, white dead silkworms 20g, dry glutinous Romania 20g, pulp of dogwood fruit 20g to boil tisane, tea and health-care drinks. Or the above Chinese medicine configuration are used to make the pill, the pellet, the injection, the medicinal powder, the oral, the aerosol, the oil emulsion, the sponginum, and the capsule. The present invention has new use of treating diabetes. The present invention mainly treats diabetes, invigorating the spleen to help the kidney and sending up the lucid yang to eliminate dampness. The present invention is suitable to patients who are in diabetes. The root of trichosanthes kirilowii, the corn tassel or American ginseng are added for patients who are with deep thirsty. The Dictamnus albus skin is added for patients who are with pruritus. The four wonderful peaceful soups are added for patients who are with canker in the skin.
A group with spinal cord injury will be trained in a 30-minute session 5 times weekly for 6 weeks. Each session will be supervised by qualified staff. Patients will undergo training with gradual increase in load and speed, according to the tolerance of each patient. The body weight support progression will start at 50 % of the patient body weight. It will be changed every 2 weeks and the load will decrease 10%. The progression of speed may be accompanied during the training period. For the robot locomotion therapy, the Lokomat system (Hocoma AG Switzerland) will be used.
The present invention relates generally to a method for the treatment and/or prophylaxis of renal-related disorders. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of glomerulosclerosis and/or end stage renal failure and/or related conditions. The method of the present invention is preferably practised by the administration of a derivative of angiotensin I. Generally, but not exclusively, the angiotensin I derivative exhibits anti-angiotensin II properties. In a preferred embodiment, the angiotensin I is des-Aspartate-angiotensin I or a derivative, homologue or analogue thereof. The present invention further contemplates compositions for use in the treatment and/or prophylaxis of renal-related disorders such as but not limited to glomerulosclerosis and/or end stage renal failure.
The invention relates to a traditional Chinese medicine combination for treating the loss of appetite of pigs and belongs to the technical field of veterinary medicines. The traditional Chinese medicine combination is prepared from the following medicinal materials in parts by weight: 18-22 parts of costustoot, 18-22 parts of immature bitter orange, 18-22 parts of fructus aurantii, 27-33 parts of rhizoma curcumae, 27-33 parts of common burreed rhizome, 18-22 parts of endothelium corneum gigeriae galli, 4.5-5.5 parts of inula flower, 18-22 parts of fructus mume, 18-22 parts of akebia stem and 4.5-5.5 parts of fructus crotonis. The traditional Chinese medicine combination is a scientific composition which is obtained through careful screening and repeated verification according to basic theory of Chinese veterinary science and in combination with the yielded fruitful results of the modern pharmacology study. A large number of clinical trials prove that the traditional Chinese medicine combination has the technical advantages of good curative effect and fast effects on inability to eat or deficiency of food of pigs. In addition, the traditional Chinese medicine combination has the advantages of wide source of raw materials, low cost, simple preparation process and convenience in administration, and has a good marketing prospect. Meanwhile, the traditional Chinese medicine combination is a pure traditional Chinese medicine preparation, is highly safe for animal bodies, and is not likely to generate medicine residue.
BACKGROUND: Astragaloside IV has emerged as a pharmaceutical monomer with great medical applications and potential. Astragaloside IV has many effects such as improving myocardial ischemia, cerebral ischemia-reperfusion injury, anti-inflammatory, analgesic, antiviral, promoting lymphocyte proliferation, and antitumor effects. However, there are few bibliometric studies on astragaloside IV.
OBJECTIVES: We aim to visualize the hotspots and trends in astragaloside IV research through bibliometric analysis to further understand the future development of basic and clinical research. Methods The articles and reviews on astragaloside IV were screened from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace software. Bibliometric analysis was performed on 971 articles published from 1998 to 2022.
RESULTS: The number of articles on astragaloside IV increased yearly. These publications came from 42 countries/regions, with China being the largest. The primary research institutions were Shanghai University of Traditional Chinese Medicine and Guangzhou University of Traditional Chinese Medicine. Journal of Ethnopharmacology was the most studied journal and co-cited journal. A total of 473 authors were included, among which Hongxin Wang had the highest number of publications and Zhang Wd had the highest total citation frequency. After analysis, the most common keywords are astragaloside IV, expression, and oxidative stress. Cardiovascular disease, cerebral ischemia, cancer, and kidney disease are current and developing research fields.
CONCLUSION: This study used bibliometrics and visualization methods to analyze the research hotspots and trends of astragaloside IV. Astragaloside IV on ischemia-reperfusion injury, cancer, and tumor may become the focus of future research.
Compositions that include a phenol group conjugated to a lipid group to form a phenolic lipid. The lipid group may include a fluorophore and at least one lipid anchor. The lipid anchor may have a carbon number that ranges between 7 carbon atoms and 22 carbon atoms. Also, included are methods of making and using such phenolic lipids. Further included are methods of iodinating hydrophobic compounds such as phenolic lipids in aqueous based iodination protocols. Cosolvent formulations for use in such methods are also described.
The aim of this study is to determine if prolonged rinsing (30 minutes) of mouth without gargling using a Hypertonic Saturated Sodium Chloride solution would reduce/eliminate the Upper Respiratory viral load in Covid-19 infected patients compared to a placebo (Plain Water Rinse). Patients who have been tested positive for COVID-19 using Nucleic Acid Test via Nose or Throat Swabs within 7 days prior to the start of the trial will be instructed to use either of the two treatment arms (Active or Placebo) for 30 minutes twice daily for two days and retested for Covid 7 days after the last treatment

A randomized blinded controlled study, whereas a number of patients (at least 20) with clinically-confirmed Covid-19 infection within 7 days prior to the start of the study, are equally divided into 2 groups, Active and Control groups, using Active and Control Mouth rinses respectively. The Active Rinse is a 25 ml of Hypertonic Saturated Saline solution made by mixing 10 grams of Sodium Chloride (Table Salt) in 25 ml of Tap water with some salt crystals deposited. The Control Rinse is a 25 ml of Plain Tap Water. Each Patient of both groups will be asked to keep the solution still in his/her mouth, close to the back of the mouth, for 30 minutes without gargling and without swallowing. After 30 minutes the solution will be spit out and mouth will be rinsed with plain water several times. The process will be done twice a day for 2 days. Patients of both groups will be tested once for Covid-19 7 days after the last treatment.