anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Different types of HPV have varying carcinogenic capabilities, and viral load is one of the key indicators of pathogenicity. Currently, there is a lack of clinical data on HPV26. This study analyzed the clinical characteristics of patients with HPV26 single infection.
METHODS: Exfoliated cervical cells were collected for HPV genotyping from women who attended gynecological outpatient clinics or physical examinations. The clinical characteristics of HPV26 single infections in both cross-sectional and follow-up studies were examined, and the association of viral load with HPV26 persistent infection and pathogenicity was investigated.
RESULTS: The HPV26 positive rate among women visiting hospitals for gynecological medical consultation or physical examination was approximately 0.09% (379/435,072). Among the HPV types tested, the detection rate of HPV26 was 0.37% (379/103,608). In the cross-sectional histopathological study of 101 patients with HPV26 single infection, 62.37% (63/101) presented lesion-free. The numbers of patients with cervical intraepithelial neoplasia (CIN) 1, CIN2, and CIN3 were 25, eight, and five, respectively. Cervical cancer was not detected in any patient. 71 patients attended follow-up examinations as well as HPV26 retesting up to two years, during which, 28.57% (6/21) of CIN1 patients have developed into high-grade lesions, and 9.61% (5/52) of lesion-free patients have progressed to CIN stage. The viral load in the CIN group was significantly higher than that in the lesion-free group (p = 0.012). Similarly, the viral load in the persistent infection group was significantly higher than that in the viral-clearance group (p < 0.001).
CONCLUSIONS: The pathogenicity of single HPV26 infections is moderate among high-risk types, warranting the inclusion of HPV26 in expanded screening for HPV. High viral load is an important factor in the persistent infection and pathogenicity of HPV26. Viral load is expected to serve as a screening risk factor for persistent infection and disease progression associated with HPV26.
NEW MATERIAL:An imidazolidinetrione derivative expressed by the formula (R is 5-7C cycloalkyl optionally having an alkyl group) and salt thereof. EXAMPLE:1-Cyclohexylimidazolidinetrione. USE:Useful as a remedy for allergic diseases, e.g. treating and preventing bronchial asthma, allergic rhinitis, allergic dermatosis, allergic conjunctivitis, etc., capable of being orally administered, particularly advantageous when applying to chronic diseases and having high safety with hardly any side effect. PREPARATION:Oxalyl chloride is reacted with an N-substituted urea in a solvent, e.g. tetrahydrofuran, etc., while cooling with ice - at room temperature to afford the compound expressed by the formula. As an alternative method, diethyl oxalate is reacted with the N-substituted urea in the presence of an organic base to provide the compound expressed by the formula.
An augmented reality display system and method for use during a surgical procedure are disclosed. An imaging device captures a real image of a surgical area during the surgical procedure generates a first data feed. A sensor device generates a second data feed. An augmented reality device including an augmented reality display generates an augmented overlay based on the first and second data feeds. The augmented overlay includes a visual portion and a non-visual visual portion. A processor receives the first and second data feeds and combines the first and second data feeds to generate the augmented overlay.
The invention discloses a traditional Chinese medicine pill containing herba dendrobii and herba stachyos, which is prepared from the following components in parts by weight: the invention relates to a traditional Chinese medicine composition for treating stomach diseases, which is prepared from 7 traditional Chinese medicines including dandelion, dendrobium, liquorice, thunberg fritillary bulb, trichosanthes root, perilla fruit, perilla leaf and the like. 1. Has no influence or little influence on normal physiological functions and no toxic or side effect. 2. The effect is nonspecific and broad-spectrum. 3. Has the effects of regulating normal mechanism of internal organs, nourishing stomach, clearing stomach, protecting stomach, invigorating qi, treating and recovering stomach heat, ascending the clear and descending the turbid, and regulating the five internal organs. 4. Can improve symptoms and signs of chronic stomach and stomach heat, strengthen body resistance and eliminate pathogenic factors.
The thin endometrium is detrimental to embryo implantation, probability of clinical pregnancy for an endometrial thickness ≤ 7 mm was significantly lower compared with cases with endometrial thickness \> 7 mm. It has been reported the granulocyte colony stimulating factor (G-CSF) increased the endometrial thickness and pregnancy rate of infertile women with thin endometrium during IVF cycle. However, most of the researches were retrospective and small sample size, and the results were conflicted among them. GM-CSF is another member of CSF superfamily, recalling more macrophage than G-CSF, which could be more effective in local homeostasis maintain and wound repair. GM-CSF has been widely used in skin repair after burn. It was also found the GM-CSF and its receptor in endometrium. In the past year, the investigators tried GM-CSF irrigation in 21 women with thin endometrium and most of them received GM-CSF after hysteroscopic examination or slight adhesion relaxing, and the preliminary data suggested that the GM-CSF may promote the endometrial growth. Does the GM-CSF gel can improve the endometrial thickness? Therefore, this study was conducted.
Parents in the intervention group will receive 1 electronic message per month in addition to the baseline and final assessments which equates to 8 contacts over a 7 month period. Specifically, intervention group participants will receive 4 education messages, 2 reminder/education messages, as well as 1 baseline and 1 final assessment survey.
PURPOSE:To provide a bathing agent composition containing an antiinflammatory agent and a silicone oil, having excellent effect to keep the moisture and prevent the dryness of the skin, free from tacky feeling of the skin after bathing and giving moist skin. CONSTITUTION:The objective composition contains (A) 0.005-20wt.% of an anti-inflammatory agent (e.g. dipotassium glycyrrhizinate) and (B) 1-50wt.% of a silicone oil (e.g. methylphenylpolysiloxane) based on the total composition as active components. The active components are compounded with oily component, dispersing agent or emulsifying agent for the oily component and conventional component for ordinary bathing agent and formed in the form of powder, granule, tablet, liquid, etc. The agent is thrown into bath water before bathing. The amount of the agent is selected to give the bath water containing 0.01-200ppm (preferably 0.02-160ppm) each of the components A and B.
FIELD: medicine.SUBSTANCE: invention relates to medicine and namely to surgery and anesthesiology and can be used for supraepineural blockade of the tibial nerve during amputation of the lower limb at the level of the upper third of the leg in patients with contraindications to the use of regional anesthesia before surgery. During amputation of the lower limb at the level of the upper third of the leg, a local anesthetic is administered through a catheter installed supraepineurally. During the operation, the tibial nerve is isolated, 5 ml of a 2% solution of lidocaine is injected subepineurally above the expected level of transection of the nerve and the nerve is transected. Without pulling the end of the nerve, in the cranial direction along the course parallel to the nerve with a 22G needle for intramuscular injections, the adventitia of the nerve is infiltrated with 5 ml of 2% lidocaine solution. Under visual control, a 20G epidural catheter is inserted in the adventitia parallel to the nerve in the cranial direction supraepineurally in the adventitia until the perforated catheter holes disappear in the tissues. The opposite end of the catheter is brought out onto the skin of the lower leg using a Tuohy needle inserted into the wound through a separate puncture in the skin on the lateral surface of the lower leg. After connecting the port for the injection of the anesthetic to the catheter, it is fixed on the skin of the thigh and a bolus of 10 ml of 0.5% ropivacaine solution is injected.EFFECT: method provides adequate anesthesia both during the operation and for a long time in the postoperative period, helps to avoid an increase in intraneural pressure and ischemia of the nervous tissue as well as additional tissue injury during catheterization both due to visual control and due to the implementation of supraepineural catheterization of the tibial nerve performed taking into account the successive preparatory stages and separation of tissues due to infiltration of the adventitia of the nerve.1 cl, 5 dwg
This cohort includes patients who developed necrotizing skin infections following venomous snakebites. These patients were treated at three hospitals in Guangdong Province between January 2020 and April 2024. The study aims to identify key risk factors, including Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels, that are associated with the development of necrotizing skin infections in these patients.
* Elitek must be reconstituted with the diluent provided in the carton.
  * Reconstitute the 1.5 mg vial of Elitek with 1 mL of diluent. Reconstitute the 7.5 mg vial of Elitek with 5 mL of diluent. Mix by swirling gently. Do not shake or vortex.
  * Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Discard solution if particulate matter is visible or product is discolored.
Use Electrico-acupuncture device to therapy. Four acupoints:Tianshu,Zigong,Guanyuan and Sanyinjiao. Every patient are supposed to have 24 times acupuncture treatment. 30 minutes per time.
BACKGROUND: Frailty has been identified as a risk factor for adverse outcomes in older adults with diabetes. This study aimed to investigate the impact of frailty on the prognosis of older adults with diabetes through a systematic review and meta-analysis, with the goal of offering insights for clinical decision-making.
METHODS: PubMed, Web of Science, Embase, Cochrane were systematically searched from inception to September 10th, 2023. Reviewers independently selected studies, extracted data and evaluated the quality of studies. Stata 15.1 Software was used to perform the meta-analysis. The primary outcomes of this study were mortality, hospitalization and disability, and the secondary outcomes were diabetes complications (including nephropathy, microvascular complications, macroangiopathy, cardiovascular events, hypoglycemia) and urolithiasis.
RESULTS: A total of 14 studies were included in this study, with low risk of bias and moderate to good quality. The results showed that frailty increased the risk of mortality (HR 1.91, 95% CI 1.55-2.35, P < .001), hospitalization (HR 2.19, 95% CI 1.53-3.13, P < .001), and disability in older adults with diabetes (HR 3.84, 95% CI 2.35-6.28, P < .001). In addition, frailty was associated with diabetes complications (including nephropathy, microvascular complications, macroangiopathy, cardiovascular events, hypoglycemia), urolithiasis.
CONCLUSIONS: Frailty is an important predictor of adverse outcomes, such as mortality, hospitalization, and disability in older adults with diabetes. Accurate assessment of the frailty in older adults with diabetes can help improve the adverse outcomes of patients.
The present invention started when a λgt11 cDNA library of normal human melanocytes was screened with antibodies directed against purified hamster tyrosinase. Two important cDNA clones were isolated: cDNA λmel 34 and λmel 17-1. It is concluded that λmel 34 contained cDNA encoding human tyrosinase. Moreover, the cDNA gene for human tyrosinase was recovered from the λmel 34 and can be used for many purposes including the production of pure human tyrosinase. This gene and its promoter are characterized herein. Studies suggested that λmel 17-1 gene product act on melanin biosynthesis's pathway distal to tyrosinase. Melanocytes preferentially express an mRNA species, Pmel 17, whose protein product cross reacted with anti-tyrosinase antibodies and whose expression correlated with the melanin content. The deduced protein structure has been analyzed and its chromosomal location in mouse and man has been mapped. The human Pmel 17 gene, designated D12S53E, maps to Chromosome 12, region 12pter-q21; and the mouse homologue, designated D12S53Eh, maps to the distal region of mouse Chromosome 10, a region also known to carry the coat color locus si (silver).
PURPOSE: A composition containing an extract of Fuscoporia obliqua useful for treatment of prostatomegaly as an effective component is provided, which has effects of preventing and treating constipation without causing the irritation to intestines and has a high analgesic effect without side effects. CONSTITUTION: The composition for treating prostatomegaly, preventing and treating constipation, reducing pain and healing a wound contains an extract of Fuscoporia obliqua(Fr.) Aoshima. For an example, Fuscoporia obliqua is cultured in a liquid medium at 27deg.C for about 25 days to produce the mycelium of Fuscoporia obliqua, which is dried and ground. Thereafter, 200g Fuscoporia obliqua powder is heated in 1,200ml water for 1hr and filtered. Or 200g Fuscoporia obliqua powder is heated in 1,000ml ethanol for 30min and filtered.
OBJECTIVES: Spontaneous pneumothorax in young patients has a high recurrence rate, even after surgical treatment, and bulla neogenesis around stapled lesions has been reported as a cause of postoperative recurrence. We investigate the clinical safety and long-term outcome of non-stapling thoracoscopic surgery for spontaneous pneumothorax in young patients.
METHODS: Twenty-seven non-stapling thoracoscopic surgeries for pneumothorax in 24 patients younger than 25 years were retrospectively reviewed. The non-stapling surgical techniques used to treat bullae included thoracoscopic suture plication, soft-coagulation, covering, and ligation. Long-term follow-up was conducted by telephone or by a mailed questionnaire.
RESULTS: In 22 (81.5%) operations, suture plication, soft-coagulation, and covering procedures were used in combination. The median number of bullae treated in one operation was 2 (range, 0-6). The median operative time was 97 min, and the median postoperative drainage and postoperative hospital stay periods were 1 and 3 days, respectively. No complications of grade 2 or higher were observed. Patients were followed for at least 30 (median, 37) months. The postoperative recurrence rate was 3.7%, with one case of recurrence due to bulla neogenesis at a distant site.
CONCLUSION: Non-stapling thoracoscopic surgery with covering procedure for pneumothorax in young patients might reduce postoperative recurrence.
Participants will receive cyclophosphamide 500 mg/m\^2/day intravenously (IV) and fludarabine 30 mg/m\^2/day IV conditioning chemotherapy for 3 days followed by axicabtagene ciloleucel administered as a single IV infusion at a target dose of 2 x 10\^6 anti-cluster of differentiation (CD) 19 chimeric antigen receptor (CAR) transduced autologous T cells/kg on Day 0. For participants weighing ≥ 100 kg, a maximum flat dose of axicabtagene ciloleucel at 2 x 10\^8 anti-CD19 CAR T cells will be administered. Participants also will receive utomilumab 10 mg on Day 1, IV infusion, once every 4 weeks (Q4W) for 6 months or until progressive disease, whichever came first.
Insulin resistance is a key underlying factor promoting hyperglycemia and hypertension in people with type 2 diabetes (T2D), who have a 3-fold greater cardiovascular disease (CVD) risk when compared with healthy controls. Despite several therapeutic approaches that favor insulin sensitivity through a variety of purported mechanisms (e.g. weight loss, incretins, AMPK activation, reduction in bioactive lipids: DAG/ceramides, etc.), long-term progression of glucose deterioration occurs. This suggests adjunctive targets may be important to prevent/reverse T2D. Studies show that extracellular vesicles (EVs) obtained from plasma are involved in obesity-induced insulin resistance at levels of adipocytes, muscle, and liver. However, little is known how plasma EVs affect vascular insulin action in humans. This is of clinical relevance as EVs enhance the Framingham Risk Score, suggesting EVs are a unique factor promoting CVD. This proposal will fill this knowledge gap by conducting a translational study in 3 distinct groups of people separated by obesity and T2D. The investigators hypothesize that 1) insulin will promote EV uptake and modify insulin signaling in endothelial cells, 2) EVs from adults with T2D will impair vessel reactivity compared to controls; 3) insulin will alter circulating EV insulin signaling and cargo, and 4) exercise training will change EV uptake and cargo as well as EV mediated vascular reactivity to insulin as well as relate to improved vascular function in humans.
Non-operative treatment with six weeks in a below-the-knee cast. Partial weight-bearing (15 to 20 kilograms) for the first four weeks and then weight-bearing as tolerated for the remaining two weeks.
During home visits in the 3rd trimester, mothers in the neonatal stimulation clusters will be taught 3 core messages pertaining to neonatal stimulation. First, mothers will be taught how to make eye contact and talk to their child. This type of interaction encourages social inclusion, attachment, and development of social-communication skills. Second, mothers will be taught techniques to foster responsive feeding and caregiving. Finally, mothers will be encouraged to sing songs and nursery rhymes, including those with gentle touch in order to support the development of communication skills, and introduce a tactile component to caregiving. These messages will be reiterated at subsequent home visits by the CHW after the baby is born.
BACKGROUND: Application of accumulated experience and management measures in the prevention and control of coronavirus disease 2019 (COVID-19) has generally depended on the subjective judgment of epidemic intensity, with the quality of prevention and control management being uneven. The present study was designed to develop a novel risk management system for COVID-19 infection in outpatients, with the ability to provide accurate and hierarchical control based on estimated risk of infection.
METHODS: Infection risk was estimated using an auto regressive integrated moving average model (ARIMA). Weekly surveillance data on influenza-like-illness (ILI) among outpatients at Xuanwu Hospital Capital Medical University and Baidu search data downloaded from the Baidu Index in 2021 and 22 were used to fit the ARIMA model. The ability of this model to estimate infection risk was evaluated by determining the mean absolute percentage error (MAPE), with a Delphi process used to build consensus on hierarchical infection control measures. COVID-19 control measures were selected by reviewing published regulations, papers and guidelines. Recommendations for surface sterilization and personal protection were determined for low and high risk periods, with these recommendations implemented based on predicted results.
RESULTS: The ARIMA model produced exact estimates for both the ILI and search engine data. The MAPEs of 20-week rolling forecasts for these datasets were 13.65% and 8.04%, respectively. Based on these two risk levels, the hierarchical infection prevention methods provided guidelines for personal protection and disinfection. Criteria were also established for upgrading or downgrading infection prevention strategies based on ARIMA results.
CONCLUSION: These innovative methods, along with the ARIMA model, showed efficient infection protection for healthcare workers in close contact with COVID-19 infected patients, saving nearly 41% of the cost of maintaining high-level infection prevention measures and enhancing control of respiratory infections.
This hospital-based, cross-sectional study aimed to explore the association between diet and fluctuating intestinal bacteria in early-stage colorectal cancer (CRC) (Atopobium parvulum, Actinomyces odontolyticus, Solobacterium moorei, and Bifidobacterium longum). Healthy participants (n = 212) who underwent total colonoscopy at National Cancer Center Hospital (Tokyo, Japan) were divided into two groups according to the relative abundance of bacteria in their feces: those in the top 25% of relative bacterial abundance as cases and the bottom 25% as controls. The participants were divided into three groups (low, medium, and high) according to their intake of food groups associated with CRC. Multivariable logistic regression analysis was conducted to estimate the association between dietary intake and higher relative abundance of bacteria. Dairy products were inversely associated with a higher relative abundance of A. parvulum, A. odontolyticus, and S. moorei, with odds ratios (high vs. low) and 95% confidence interval as follows: 0.16 (0.06-0.44), 0.25 (0.08-0.82), and 0.29 (0.11-0.78), respectively. Additionally, dietary fiber was inversely associated with a higher relative abundance of S.moorei (0.29 [0.11-0.78]). No association was observed between diet and B.longum. In conclusion, healthy adults with a higher intake of dairy products and fiber had lower odds of having a higher relative abundance of CRC-associated microbiota.
Arm II:At the 4-week dose-titration phase, will receive one capsule of placebo twice daily from Day 1 to Day 7, and two capsules of placebo twice daily from Day 8 to Day 14. From Day 15 to Day 28, patients will perform dosage adjustments based on the pain relief and tolerability. At maintenance phase, patients will take the optimized dosage of placebo.
PROBLEM TO BE SOLVED: To improve convenience when prescriptions and medicine notebooks are computerized.SOLUTION: After a diagnosis of a patient, an in-hospital device 32 transmits information on prescriptions to a data server 91, allows the data server to record them, and further transmits, to the data server 91, a dispensing reservation request including a prescription ID and a transmission destination pharmacy ID representing a pharmacy to which the dispensing is requested. The data server 91, in response to the dispensing reservation request, records dispensing reservation information including the prescription ID and the transmission destination pharmacy ID. An in-pharmacy device 62 periodically monitors the data server 91, acquires the dispensing reservation information and detects whether or not there is a dispensing request of medicine. When there is a request of dispensing, the in-pharmacy device 62 acquires the information related to the prescriptions from the data server 91. The pharmacy side can thus start the dispensing before a visit of the patient. This invention can be applied to an information processing system.