anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Clinically, the immune checkpoint inhibitor anti-PD-1 antibody has shown a certain effect in the treatment of hepatocellular carcinoma (HCC), which is limited to a small number of patients with HCC. This study aims to reveal whether carnosic acid nanocluster-based framework (CA-NBF) has a sensitization effect on anti-PD-1 antibody in the treatment of HCC at the cellular and animal levels. MHCC97H cells were treated with CA-NBF, anti-PD-1 and their combination. The effects of CA-NBF and anti-PD-1 on cell proliferation, cell cycle, apoptosis, invasion, and migration were evaluated by MTT assay, flow cytometry, and scratch test. The effects of CA-NBF and anti-PD-1 on Wnt/β-catenin signaling pathway in MHCC97H cells were detected. A BALB/C nude mouse model of hepatocellular carcinoma was established, and the tumor growth was observed at different time points. The expression of cytotoxic T lymphocyte and helper T lymphocyte markers CD8 and CD4 in tumor tissues was detected by immunohistochemistry. Western blotting was used to detect the Wnt/β-catenin signaling pathway proteins (Wnt-3a, β-catenin, and GSK-3β) level in tumor tissues after CA-NBF and anti-PD-1 treatment. CA-NBF activity was significantly higher than CA, which could prominently reduce the proliferation, migration and invasion of MHCC97H cells and enhance apoptosis by inactivating Wnt/β-catenin signaling pathway. CA-NBF combined with anti-PD-1 antibody further enhanced cell proliferation, migration, invasion and pro-apoptosis but had no significant effect on Wnt/β-catenin signaling pathway. CA-NBF in vivo improved the tumor response to PD1 immune checkpoint blockade in HCC, manifested by reducing tumor size and weight, promoting CD4 and CD8 expression. CA-NBF combined with anti-PD-1 have stronger immunomodulatory and anticancer effects without increasing biological toxicity.
Novel polyisoprenylated benzophenone derivatives isolated from the plant  Garcinia paucinervis . Among these new compounds, paucinones A-C (Compounds 1-3) contains an unexpected cyclohexane-spiro-tetrahydrofuran moiety. A 1-methylene-3,3-dimethylcyclohexane group never reported before was found in the structure of paucinone D (Compound 4). Structures of these compounds were elucidated with spectroscopic evidence. The relative stereochemistry of 1-4 was determined by NOESY correlations. These compounds a potent ability to activate caspase-3 in HeLa-C3 cells within 72 hours at a low concentration and significant cytotoxicity against HeLa-C3 cells.
Hemiplegic shoulder pain (HSP) is a common complication that occurs after stroke and has been reported in up to 84% of hemiplegic patients. One of the recommended treatment options for shoulder pain is high-intensity laser therapy (HILT). This study aimed to determine the effectiveness of high-intensity laser therapy on pain, function and hand grip strength in patients with hemiplegic shoulder dysfunction. Forty-four hemiplegic patients were randomly divided into two groups: Group 1 (study group, n = 22) received 3 HILT sessions a week for three weeks in combination with three sessions of therapeutic exercise per week for three weeks, and Group 2 (control group, n = 22) received a conventional exercise program for HSP three times a week for three weeks. Shoulder pain was evaluated using the McGill pain questionnaire (MPQ), the functional outcome of the shoulder was evaluated with the University of California-Los Angeles functional scale (UCLA), and handgrip strength was evaluated with a hydraulic hand dynamometer. The increase in the UCLA scores and the decrease in the MPQ scores after treatment were significant in the study group (p < 0.001) as well as in the control group (p < 0.05) in comparison with the pretreatment between-group comparison. Additionally, the increase in hand grip strength was significant in both groups after treatment (p < 0.001). The study group showed significant improvement over the control group with respect to the UCLA score, handgrip strength, and MPQ score (p < 0.001). HILT combined with therapeutic exercise provides greater improvement than therapeutic exercise alone in terms of hemiplegic shoulder pain, dysfunction, and handgrip strength.
The utility model aims to discloses a Valnemulin long-acting granular pill which comprises the following components: a substrate pill as a core, a medicine layer, a polymer slow-releasing coating layer and a color coating layer. The medicine layer is coated on the substrate pill. The polymer slow-releasing coating layer and the color coating layer are successively coated outside the medicine layer. The Valnemulin long-acting granular pill effectively settles the problems of short half-life period of Valnemulin and requirement for multiple times of medicine administration in prior art. A target of medicine slow-releasing is realized through mixed pelletizing between Valnemulin and a retarding agent. Half-life period of the medicine is greatly prolonged and the curative effect of the medicine is improved.
Brain imaging and genomics are critical tools enabling characterization of the genetic basis of brain disorders. However, imaging large cohorts is expensive and may be unavailable for legacy datasets used for genome-wide association studies (GWASs). Using an integrated feature selection/aggregation model, we developed an image-mediated association study (IMAS), which utilizes borrowed imaging/genomics data to conduct association mapping in legacy GWAS cohorts. By leveraging the UK Biobank image-derived phenotypes (IDPs), the IMAS discovered genetic bases underlying four neuropsychiatric disorders and verified them by analyzing annotations, pathways, and expression quantitative trait loci (eQTLs). A cerebellar-mediated mechanism was identified to be common to the four disorders. Simulations show that, if the goal is identifying genetic risk, our IMAS is more powerful than a hypothetical protocol in which the imaging results were available in the GWAS dataset. This implies the feasibility of reanalyzing legacy GWAS datasets without conducting additional imaging, yielding cost savings for integrated analysis of genetics and imaging.
The ability of the neuromuscular and musculoskeletal systems to generate force at a specific velocity, in a particular direction, appears to be critical for many sports that involve sprinting, jumping and throwing. In light of the above, plyometric training can be used to enhance the ability of skeletal muscle to exert maximal force in as short a time as possible. Plyometric training typically includes various unilateral and bilateral jumps, hops and bounds with coaches often prescribing these in a multidirectional fashion to reflect the unpredictable nature of field and court sports. The rationale of this approach is founded on the well-accepted principle that adaptations to vertically (VPT) and horizontally orientated PT will transfer better to athletic tasks that are carried out in the same direction as they are performed. Plyometric consists of a rapid stretching of a muscle (eccentric action) immediately followed by a concentric or shortening action of the same muscle and connective tissue, the stored elastic energy within the muscle is used to produce more force than can be provided by a concentric action alone. Though aerobic capacity is important during a soccer game high-intensity single-bout efforts also play an important role for physical performance. in this sense, aside from endurance activity, female soccer players must also perform numerous explosive action including jumping, kicking, accelerating, decelerating and changing of direction, with most of these preceding goal opportunities in competitive leagues. specifically, the straight sprint (45%) followed by vertical jumps (16%) have shown to be the two most frequent actions in goal situations during professional soccer matches. Studies also suggest that changes in motor performance skills resulting from the performance of combined resistance training and plyometric training are greater than with either type of training alone. Six weeks of combined resistance training and plyometric training would lead to greater improvements in fitness performance in healthy boys than resistance training and static stretching. Plyometric training has been proposed for the development of explosive power performance and specifically for the improvement of vertical jump ability. he main finding of this study was the improvement of either vertical- and horizontal jump performance in basketball players as a consequence of a multipurpose plyometric training intervention.
To investigate the safety and feasibility of gasless total endoscopic resection of deep lobe parotid gland tumors via a postauricular hairline plus temporal approach. The approach was designed as: a 4 to 5 cm main incision was designed at the postauricular hairline, and a 0.5 cm auxiliary incision was designed in the temporal hairline. The operating cavity was established with the assistance of a special retractor. "Anterograde" dissection of the facial nerve was performed throughout the procedure, along with partial or total gland removal of the tumor. All 16 operations were successfully completed without conversion to open surgery. During the operation, the trunk and branches of the facial nerve were completely preserved, the tumor was completely removed, and the incision healed. Six patients had mild facial paralysis after operation, and recovered completely after 3 to 6 months. There was no salivary fistula, Frey syndrome, infection, or other complications. The postoperative incision was concealed and the aesthetic effect was good. The postauricular hairline plus temporal approach gasless total endoscopic parotidectomy is safe and feasible. This technique can achieve the complete dissection of the total trunk to the branches of the facial nerve, and has good access to the tumors located in any part of the parotid gland region. On the basis of radical resection of the tumor, it achieves minimally invasive and aesthetic improvement.
In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with clomipramine hydrochloride capsules either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7,000 mg. The second death involved a patient suspected of ingesting a dose of 5,750 mg. The 10 nonfatal cases involved doses of up to 5,000 mg, accompanied by plasma levels of up to 1,010 ng/mL. All 10 patients completely recovered. Among reports from other countries of clomipramine hydrochloride capsules overdose, the lowest dose associated with a fatality was 750 mg. Based upon postmarketing reports in the United Kingdom, CMI's lethality in overdose is considered to be similar to that reported for closely related tricyclic compounds marketed as antidepressants.
Both groups will come back to the hospital weekly in order to assess items such as patient's level of anxiety, depression, your adherence, and also to monitor for side effects. The patient's will complete questionnaires during your visit. These will take approximately 15 minutes to complete. This will continue for 6 total weeks for patient's on the control arm.
PURPOSE:To obtain a composition containing antibacterial agent and having improved absorbability and durability, by compounding an antibacterial agent selected from quinolonecarboxylic acid compound and pyridonecarboxylic acid compound with a phospholipid, cyclodextrin, etc. CONSTITUTION:The objective composition containing an antibacterial agent is produced by compounding at least one kind of antibacterial agent selected from quinolonecarboxylic acid compound having the structural formula I and pyridonecarboxylic acid compound having the structural formula II with at lease one kind of component selected from phospholipid, cyclodextrin (abbreviated as CD) and collagen. The CD, collagen and phospholipid added to the above component promote the absorption of the antibacterial agent and prolong the antibacterial activity. The amount of CD, etc., is 10-2,000 pts.wt. each, preferably 50-1,000 pts.wt. each per 100 pts.wt. of the antibacterial agent. The antibacterial effect of the composition can be further improved by the addition of an antibiotic substance.
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.
The clinical utility of hemoglobin-based oxygen carriers (HBOC) is limited by adverse heme oxidative chemistry. A variety of tyrosine residues were inserted on the surface of the γ subunit of recombinant fetal hemoglobin to create novel electron transport pathways. This enhanced the ability of the physiological antioxidant ascorbate to reduce ferryl heme and decrease lipid peroxidation. The γL96Y mutation presented the best profile of oxidative protection unaccompanied by loss of protein stability and function. N-terminal deletions were constructed to facilitate the production of recombinant hemoglobin by fermentation and phenylalanine insertions in the heme pocket to decrease the rate of NO dioxygenation. The resultant mutant (αV1del. αL29F, γG1del. γV67F, γL96Y) significantly decreased NO scavenging and lipid peroxidation in vitro. Unlike native hemoglobin or a recombinant control (αV1del, γG1del), this mutation showed no increase in blood pressure immediately following infusion in a rat model of reperfusion injury, suggesting that it was also able to prevent NO scavenging in vivo. Infusion of the mutant also resulted in no meaningful adverse physiological effects apart from diuresis, and no increase in oxidative stress, as measured by urinary isoprostane levels. Following PEGylation via the Euro-PEG-Hb method to increase vascular retention, this novel protein construct was compared with saline in a severe rat reperfusion injury model (45% blood volume removal for 90 minutes followed by reinfusion to twice the volume of shed blood). Blood pressure and survival were followed for 4 h post-reperfusion. While there was no difference in blood pressure, the PEGylated Hb mutant significantly increased survival.
The present invention discloses a loratadine orally disintegrating tablet used for treating anaphylactic diseases and a preparation method thereof. The loratadine orally disintegrating tablet comprises loratadine active ingredients and medical acceptable auxiliary material. The loratadine orally disintegrating tablet is characterized in that the weight percentage of loratadine is from 2 to 25%, and the weight percentage of the auxiliary material is from 75 to 98%; the auxiliary material contains disintegrating agents, bulk additive, corrigent and sweetening agents, wherein the weight percentage of the disintegrating agents is from 5 to 40%, the weight percentage of the bulk additive is from 10 to 60%, the weight percentage of the corrigent is from 0.1 to 1%, and the weight percentage of the sweetening agents is from 1 to 30%. The preparation method can adopt a freezing drying method, a powder pressing tablet method and a wet granulation pressing tablet method. According to the different preparation methods, the partial auxiliary material or the whole auxiliary material which has various purposes can be selected from the ingredients. Compared with other loratadine preparations, the present invention has the advantages of rapid disintegration, convenient administration and good mouth feel. Various ingredients and preparation methods can be selected. A market prospect is wide.
A specific clinical protocol for use toward therapy of defective, diseased and damaged neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative conditions such as Parkinson's disease and Alzheimer's disease. The protocol is practiced by delivering a definite concentration of recombinant neurotrophin, such as glial cell-derived neurotrophic factor), into a targeted region of the brain (such as the substantia nigra) using a lentiviral expression vector. The neurotrophin is delivered to, or within close proximity of, identified defective, diseased or damaged brain cells. The concentration of neurotrophin delivered as part of a neurotrophic composition varies from 10<SUP>10 </SUP>to 10<SUP>15 </SUP>neurotrophin encoding viral particles/ml of composition fluid. Each delivery site receives from 2.5 mul to 25 mul of neurotrophic composition, delivered slowly, as in over a period of time ranging upwards of 10 minutes/delivery site. Each delivery site is at, or within 500 mum of, a targeted cell, and no more than about 10 mm from another delivery site. The method stimulates growth of targeted neurons, and reversal of functional deficits associated with the neurodegenerative disease being treated.
A vaccine produced in edible plant and/or animal products, as well as a method of second-generation vaccine development through the production of at least one complete structure of a pathogen in a transgenic plant or animal is described. Preferably, the present invention enables the production of virus-like particles in edible food plants, through the co-expression of a plurality of proteins and/or of a plurality of portions of such proteins. The co-expression of viral structural proteins should enhance the immunogenicity of the transgenic antigen by providing all elements necessary to induce a protective immune response. In one variation of the method the immune response to the transgenic vaccine would be induced by presenting the transgenic proteins as part of an edible plant structure, utilizing this to stimulate the mucosal immune system. Alternatively, the vaccine produced in transgenic plant/animal products could be purified and used as an immunogen in other vaccination strategies. A corollary to this claim is the use of transgenic plant-derived viral vaccines as recombinant vectors to shuttle host or therapeutic genes to the liver or other tissues of the body utilizing the natural trophism of the virus. A second method of vaccination, that involves the stimulation of mucosal immunity, includes the use of conventional vaccines that are applied to the surface of the rectum to induce an immune response that is manifest both locally (in the intestinal mucosa) and systemically (blood and other body tissues).
PROBLEM TO BE SOLVED: To perform the design of a stent graft while three-dimensionally observing the installing state of the stent graft in a blood vessel by providing a means to calculate the length of an obtained stent graft model, and a means to store the information regarding the obtained stent graft model. SOLUTION: In this stent graft designing device, for the outline of the overall processing procedures, which are performed by a CPU, based on a blood vessel region extracting program, a blood central axis determining program and a stent graft designing program, first, the extracting process for a blood vessel region including an aneurysm section is performed (S1). That is, based on the blood vessel image of a patient, a blood vessel region including the aneurysm section is extracted, and a three-dimensional blood vessel model is formed. Then, the determining process for the blood vessel central axis is performed (S2). That is, the blood vessel central axis is determined, based on the three- dimensional blood vessel model. Then, the stent graft designing process using the stent graft model is performed (S3).  That is, a stent graft in response to the blood vessel of the patient is designed.
FIELD: splinter ammunition. SUBSTANCE: base charge of explosive, tail fuse with detonator and graze percussion mechanism with delay member are located in housing. Front part of housing is carried out with conic or curved surface, directed by top to shell bottom. Head hood is filled by low-dense material. Contact reaction unit connected to the tail fuse by means of electrical communication with member for regulated delay of explosion of base charge is disposed in front part of head hood. Case is positioned between front part of housing and head hood. Block of prepared injuring members is located in case, it can be provided with charge of explosive with detonator. In addition injuring members are carried out in the form securing their compact placing into block. Housing can be carried out with assigned crushing or with meniscus members for forming of blow cores. Version of charge provides carrying out of housing with stagger in front part and front bottom installed with stop in stagger. EFFECT: simultaneous axial and circular injury. 15 cl, 8 dwg
Hallux rigidus and hallux valgus are chronic forefoot conditions associated with pain, inflammation and functional impairment. While operative interventions exist, nonoperative modalities are the mainstay of treatment for most patients. Options include shoe wear modification, manual and physical therapy, intraarticular injection of corticosteroids or sodium hyaluronate, oral nonsteroidal anti-inflammatories, and foot orthoses. Oral anti-inflammatories are the most effective non-operative strategy, but unfortunately, are associated with major adverse side effects and are contraindicated in many patients. Topical cannabidiol (CBD) cream has been shown to decrease inflammation, swelling, and pain response in arthritis models with minimal side effects, although the intervention has never been studied in hallux valgus or hallux rigidus. This prospective randomized trial will compare topical CBD cream vs placebo cream for the treatment of pain secondary to hallux valgus and hallux rigidus. The primary outcome of interest in the change in pre and post-treatment Visual Analog System (VAS) pain scores. VAS pain score is a measurement on a continuum of values of pain intensity. The purpose of this study is to determine if topical CBD cream is an effective treatment for pain secondary to hallux rigidus and hallux valgus.