anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An anal fistula is an abnormal communication between the anal or rectal lumen and the perianal skin. Anal fistulae are described according to the level at which they transgress the anal sphincter. If the internal opening begins above the anal sphincter then the fistula is described as 'high'. Traditional surgery for high-type anal fistulae often requires staged operations with fistulotomy and seton insertion. The surgery usually results in large and deep wounds which can take months to heal. Moreover, risk of faecal incontinence is inevitable because part of the anal sphincter is divided during the surgery.

The Surgisis® anal fistula plug is a minimally invasive and sphincter-preserving alternative to traditional fistula surgery. It is a newly developed biomaterial made from complex collagen obtained from pigs - animals that have a collagen structure almost identical to that of human tissue. During manufacturing of the plug, living cells are removed by special processes to help ensure that no transmittable diseases are present in the tissue. The plug is a conical device and is placed by drawing it through the fistula tract and suturing it in place. As pig collagen is so similar to human collagen, the plug, once implanted, incorporates naturally over time into the human tissue (human cells and tissues will 'grow' into the plug), thus facilitating the closure of the fistula. Preliminary clinical data from USA showed a high fistula closure rate of 87%. The anal fistula plug can also avoid protracted postoperative wound care and minimise the risk of faecal incontinence.

We would like to carry out a pilot study, the aim of which is to evaluate the efficacy and safety of this new anal fistula plug in the management of high-type anal fistulae. This is believed to be the first study of its kind in Hong Kong.

Patients with high-type anal fistulae confirmed by MRI will be recruited into this study. Patients with previous history of fistula surgery, patients with Crohn's disease, and patients with known allergy to porcine material will be excluded. EUA + anal fistula plug will be performed. Outcome measures include fistula healing rate, recurrence rate, and morbidity. Follow-up MRI will be arranged at 3 months and 6 months after the operation to objectively evaluate the healing of the fistulae.
Neck circumference (NC) is associated with various diseases. However, its association with pulmonary diseases remains unclear. This study aimed to investigate the association between NC and pulmonary function in Korean adults. Data from the 2019 Korean National Health and Nutrition Examination Survey were used, including forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). A total of 3818 adults aged 40 to 79 years were included in the analysis. Multivariable logistic regression models were used to examine factors associated with low pulmonary function (<80% of the predicted value) and calculate odds ratios (ORs) and 95% confidence intervals (CIs) for decreased lung function per 1-cm increase in NC. A negative correlation was observed between the NC and pulmonary function in both sexes. In multivariate logistic regression analyses, in contrast to men, women exhibited a notable relationship between increased NC and impaired pulmonary function, with a more pronounced effect observed in FVC (OR, 1.14; 95% CI, 1.05-1.24). Central obesity may play a role in pulmonary function decline. Understanding this relationship can inform preventive strategies and interventions to improve the respiratory health of individuals with central obesity.
Good pain management practice dictates that the dose be individualized according to patient need using the lowest beneficial dose. Studies with tramadol in adults have shown that starting at the lowest possible dose and titrating upward will result in fewer discontinuations and increased tolerability.

  * In all patients with creatinine clearance less than 30 mL/min, it is recommended that the dosing interval of tramadol hydrochloride be increased to 12 hours, with a maximum daily dose of 200 mg. Since only 7% of an administered dose is removed by hemodialysis, dialysis patients can receive their regular dose on the day of dialysis. 
  * The recommended dose for adult patients with cirrhosis is 50 mg every 12 hours. 
  * In general, dose selection for an elderly patient over 65 years old should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. For elderly patients over 75 years old, total dose should not exceed 300 mg/day.
The cohort data of patients with NSCLC will follow up from diagnosis, treatment response and final survival. Fibrocytes will be checked on the date of diagnsis (before treatment), re-staing (3months after treatment) and disease progression.
The invention relates to traditional Chinese medicine for relieving coughs and reducing sputum. Salty rhizoma anemarrhenae is used for tonifying the spleen and the kidney. Chinese fevervine herbs and roots, ageratum conyzoides, pterocephalus hookeri and coptes teeta are used for clearing away lung heat. Chinese forgetmenot roots, medicine terminalia fruits, siegesbeckia orientalis, herba gerberae piloselloidis, shortleaf kyllinga herbs, mountain ebony, lindley eupatorium herbs and lilac daphne flower buds are used for moistening the lung to arrest coughs. Pinellia ternate, Japanese inula herbs, vernonia cinerea, lindley eupatorium herbs and justicia adhatoda are used for resolving sputum and relieving asthma. Japanese inula herbs are used for inhibiting bacteria. Carpesium abrotanoides and lilac daphne flower buds are used for eliminating sputum, and the good curative effect is achieved in clinical application.
Giant cell arteritis (GCA), the most common primary vasculitis in adults, is a granulomatous systemic vasculitis usually affecting the aorta and its major branches, particularly the carotid and vertebral arteries. Although remission can be achieved in most patients with GCA using high-dose glucocorticoids (GC), relapses are frequent, occurring in >40% of GC-only treated patients, mostly during the first two years after diagnosis. Relapsing courses lead to high GC exposure, increasing the risk of treatment-related adverse effects. Although tocilizumab is an efficacious GC-sparing therapy that allows increased sustained remission and reduced cumulative GC doses, relapses are common after drug discontinuation. This narrative review examines the most relevant features of relapses in GCA, including its definition, classification, frequency, clinical, laboratory, and imaging characteristics, chronology, probable pathophysiology, and predictive factors. In addition, we discuss treatment options for relapsing patients and the effect of relapses on patient outcomes.
FIELD: chemistry.SUBSTANCE: described is a method of producing a dispersible nonwoven substrate in an aqueous medium comprising, consisting of or consisting essentially of bringing into contact a fibrous substrate with an aqueous nonwoven binder containing an emulsion polymer, having a polydispersity coefficient of at least 10, weight average molecular weight of less than 1,000,000 and 8 wt. % to 22 wt. % of acid monomer by weight of emulsion polymer. Aqueous nonwoven binder can be obtained by a method involving the following steps: a) emulsion polymerisation of at least one monoethylenically unsaturated monomer and at least one acidic monomer in an aqueous solution using an initiator, wherein the initiator is present in the aqueous solution in amount of 0.5 wt. % to 1.5 wt.  % of total weight of monomers, to obtain an emulsion polymer; and b) neutralizing the emulsion polymer with a neutraliser selected from a group consisting of an amine having pKb from 4 to 7, hydroxide of an alkali metal and combinations thereof to obtain an aqueous nonwoven binder.EFFECT: dispersible non-woven substrates can be used to produce dispersible napkins, such as baby napkins, sanitary napkins, cleaning napkins, or any other wet non-woven materials containing lotion with pH less than 5 or 6.13 cl, 13 tbl
Disease perception is the cognitive aspect of the disease state. Although they experience the same disease in a certain period of their lives, the methods of meeting the disease and coping with the disease differ. Patients try to explain their illnesses in the light of their personal experiences, knowledge, values, beliefs and needs. People create cognitive models to explain and predict events in the outside world. Patients also develop similar patterns of symptoms of transient or long-term disease. Leventhal et al. suggested that patients formed their own coping mechanisms with these cognitive models and developed the self-regulation theory. According to this theory, people create schemas about illness and life-threatening situations in their minds with the information presented to them from concrete and abstract sources. These cognitive models also include beliefs about treatment and control of the condition.

The World Health Organization (WHO) has classified more than 200 musculoskeletal diseases, the most common being rheumatoid arthritis and osteoarthritis. The biopsychosocial model has been drawing attention in rheumatological rehabilitation in recent years. This model acknowledges that the experiences and symptoms of the disease are affected by biological, psychological and social factors. The dysfunction is not only related to the severity of the disease, but also to how the disease is perceived. The patient's beliefs and perceptions about his illness show how the illness affects him both physically and emotionally. Disease perception is based not only on symptoms but also on disease-related consequences, concerns, and past illness experiences of the patient. Recent studies emphasize the importance of disease perception in explaining the difference in treatment outcomes in chronic diseases, including rheumatic diseases.

It was planned to determine the validity and reliability of the Disease Perception Scale in Rheumatic Diseases due to the importance of treatment in rheumatic diseases and the evaluation of disease perception in terms of the course of the disease.
INTRODUCTION: Doctors with disability are likely to face major life crises, challenges and distressing emotions from unforeseen circumstances that threaten their physical well-being. We aimed to identify the existence of work-related pain and discomfort that may cause surgeon's disability. Surgeons who were struck with unpredictable disasters leading to disabilities were also reviewed.
METHODS: We conducted a 10-year literature review. In addition, citations about surgeons' physical disabilities were complemented with commentaries about disabled surgeons from gray literature. The quantitative citations were quality assessed by MERSQI scores and evidence graded according to GRADE. For the qualitative study part, the severely traumatized surgeons were analysed by means of Cullberg's crisis phases (CCP) and analysed from Tedeschi and Calhoun's post-traumatic growth perspective (PTG).
RESULTS: Altogether 3593 citations from PubMed were studied, and 10 citations met inclusion criteria with a total of 11591 participants. We included 6 surgeons subjected to highly traumatic events complicating their medical career. Our quantitative citations' mean MERSQI score was 11.73 (SD .79) and the citations' evidence value completed grade II (moderate quality: 11.26 to 12.00 scores). Work-related musculoskeletal pain and occupational injuries may lead to physical disabilities. The accidentally traumatized surgeons fought through the four CCP phases and reached successfully the PTG stage.
CONCLUSIONS: The surgical workforce is at high risk of work-related musculoskeletal morbidity which can progress to chronic pain and disruption of surgeon's career. Surgeons with disabilities faced serious barriers in their career. Institutions and healthcare systems must urgently develop support strategies for surgeons with disabilities.
Patients undergo high-dose-rate brachytherapy over 2 fractions. Patients also receive ADT comprising bicalutamide PO QD. Patients may also receive LHRH agonist therapy comprising leuprolide acetate IM or SC, goserelin acetate SC, triptorelin pamoate IM, or degarelix SC for 4-6 months (intermediate-risk patients receiving ADT) or 6-36 months (high-risk patients) at the discretion of the treating physician.
Diabetes is a long-term chronic disease. The patients need to correct "knowledge and action" lifestyle in order to achieve effective blood glucose control. Upon the general control of diabetic patients in Taiwan, however, glycosylated hemoglobin (HbA1c) is not satisfactory. One of the important reasons is the low rate of insulin injection. For the use of insulin, the patient has many misconception. The patients in the clinic need to spend a lot of time to explain and description, but the results are not necessarily good. So we hope that in this part of the health education activities through organized groups Videos to assist doctors and patients as a bridge of communication, to enhance diabetes doctor thus contributing to glycemic control results.
The invention disclosed a traditional Chinese medicine used for treating radiodermatitis. The traditional Chinese medicine is characterized in that: the medicine is prepared from raw medicines of: 8 to 10 parts of ginseng, 6 to 10 parts of mongolian milkvetch root, 8 to 10 parts of ligusticum, 8 to 12 parts of amur corktree bark, 6 to 10 parts of philippine violet herb, 8 to 12 parts of honeysuckle flower, 6 to 12 parts of weeping forsythia fruit, 6 to 10 parts of ligusticum chuanxiong hort, 6 to 10 parts of salvia miltiorrhiza, 6 to 8 parts of Tuckahoe, 6 to 8 parts of oriental waterplantain tuber, and 6 to 10 parts of licorice. The raw medicines are selected, mixed, infused, and are decocted into decoctions with water. The specification of the decoctions is 200ml/decoction. The decoctions are orally taken twice a day and 100ml each time. A treatment course comprises 15 days. The traditional Chinese medicine has functions of qi and blood replenishing, heat clearing, detoxicating, blood circulation activating, stasis removing, granulation promoting, and wound healing. The traditional Chinese medicine is applied clinically according to differentiated symptoms. The materials of the medicine are easy to obtain, the preparation method is simple, the medicine is economic and cheap, and the medicine brings no toxic and side-effect. The traditional Chinese medicine is suitable for acute and chronic radiodermatitis patients.
Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.
PROBLEM TO BE SOLVED: To obtain an analog useful for treatment, etc., of osteoporosis by independently synthesizing precursor peptide fragments of a parathroid hormone or its related peptide, then mutually condensing the resultant fragments and subsequently removing the amino acid-protecting groups. SOLUTION: This method is a synthetic one for a synthetic polypeptide analog of a parathroid hormone (PTH) or a parathroid hormone related peptide (PTHrP) or its salt. An amphiphilic α-helix is formed from amino acid residues selected from among formula I (Xaal and Xaa4 are each Glu, His, Phe, etc.; Xaa2 is Leu or Phe; Xaa5 is Lys or His; Xaa7 and Xaa10 are each Leu or Ile; Xaa8 is Ala, Arg, etc.; Xaa9 is Lys or Glu), formula II (Xaa8 is Glu or Arg), formulae III to V, etc., and precursor peptide fragments of the polypeptide are synthesized and mutually condensed. The amino acid protecting groups are then removed to thereby afford the objective analog of the hormone and its related peptide.
PURPOSE:To obtain an anti-inflammatory analgesic agent for external use containing glycol salicylate in stable state, suppressing the interaction of the glycol salicylate used as a principal drug with a humectant, by adjusting the amount of the humectant relative to the principal drug, and adjusting the pH of the mixture. CONSTITUTION:An anti-inflammatory analgesic agent for external use containing glycol salicylate and a humectant in stable state can be produced by using glycol salicylate as a principal drug component, adding a humectant thereto, and adjusting the pH of the mixture to 4.0-6.5, preferably 5.0-6.4. The humectant is e.g. polyhydric alcohol (e.g. ethylene glycol, PEG, propylene glycol, etc.) and its amount is preferably 0.5-10pts. per 1ph. of the principal drug. Glycol salicylate effective for the preparation of an odorless or odorizable anti- inflammatory analgesic agent for external use can be compounded stably to the agent.
The intervention was guided by the Health Belief model. The topics to be covered and the content of the educational program were designed with input from dietitians working with PLHIV to ensure the relevance for the target participants. Participants randomized into the intervention group received individualized sessions with a registered dietitian once a month for 6 months. During the sessions, the dietitian elaborated on the medical nutrition therapy for each participant which consists of nutritional diagnosis and nutritional counseling services. Topics covered include general nutrition knowledge, MyPlate food groups, immune-boosting foods and nutrients, improving physical activity levels, the nutritional aspects of the existing co-morbidities such as hypertension, diabetes, etc. The intervention provided by the dietitian (primary investigator) which was guided by the Health Belief Model (HBM) which suggests that an individual's beliefs about health threats, perceived benefits of acting, and perceived barriers to acting are key determinants of health-related behaviors. Each session lasted for approximately 30-45 minutes through virtual platforms or in-person, or a combination of both, using several teaching tools such as discussions, demonstrations, educational materials, and educational videos.

The participants were met with online once per month and they were followed up on weekly basis on Whatsapp to reinforce the last session message.
Antimicrobial treatment of a bacterial corneal ulcer is generally effective in eradicating infection. However, "successful" treatment is not always associated with a good visual outcome. The scarring that accompanies the resolution of infection leaves many eyes blind. Some cornea specialists advocate the use of topical corticosteroids along with antibiotics in an effort to reduce immune-mediated tissue damage and scarring. Others fear using steroids to reduce the cornea's immune response will prolong or even exacerbate infection. Ophthalmologists have been divided on this issue for more than 30 years, and both approaches are acceptable according to the American Academy of Ophthalmology's Preferred Practice Patterns. Evidence from animal and human reports is mixed. A single randomized trial saw a non-significant benefit to steroids but was drastically underpowered (20 patients per study arm).

The study is a randomized, double-masked, placebo-controlled trial to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers. Five hundred bacterial corneal ulcers presenting to the Aravind Eye Hospitals, the University of California, San Francisco (UCSF) Proctor Foundation, and the Dartmouth-Hitchcock Medical Center will be randomized to receive antibiotic plus steroid or antibiotic plus placebo. Participants will be followed closely until re-epithelialization and then rechecked at three weeks, three months and 12 months post enrollment. A subset of patients will be contacted for a follow-up visit four years post enrollment. The primary outcome is best spectacle-corrected visual acuity three months after enrollment, using best spectacle-corrected enrollment visual acuity as a co-variate.

A pilot study was conducted from January 2005 to August 2005 at Aravind Eye Hospital to assess the feasibility and safety and to estimate the sample size of a larger main trial. Forty-two patients with culture-proven bacterial keratitis were enrolled. They were treated and followed up as in the main trial, up to three months from enrollment.
A digestion helping and appetite stimulating pill belongs to the technical field of healthy foods. The digestion helping and appetite stimulating pill is formed by eleven raw medicines comprising Fructus Amomi, Radix Pseudostellariae, cinnamon, malt, chicken's gizzard membrane, dried orange peel, hawthorn fruit and other raw medicines, and is processed by using pharmaceutical apparatus to prepare a capsule, a tablet, a pill, a granule and an oral liquid for later use. The digestion helping and appetite stimulating pill has the efficacies of spleen invigorating, appetite stimulating, fat eliminating, stasis dissolving, qi moving, retention breaking, middle warmer regulating and food digesting. The digestion helping and appetite stimulating pill has good effects on impairment by overeating, apocleisis, poor appetite, dyspepsia, hyperlipidemia and other symptoms. The digestion helping and appetite stimulating pill is especially suitable for children to administrate. The digestion helping and appetite stimulating pill is a food, also has medicinal effects, and also has appetizing, food retention eliminating, appetite increasing, blood fat reducing and health maintaining effects. The digestion helping and appetite stimulating pill has the advantages of convenient administration, safety and no toxic side effects.
Apraclonidine should not be used in patients receiving MAO inhibitors (see CONTRAINDICATIONS). Although no specific drug interactions with topical glaucoma drugs or systemic medications were identified in clinical studies of apraclonidine ophthalmic solution 0.5%, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, anesthetics) should be considered. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine. It is not known whether the concurrent use of these agents with apraclonidine can lead to a reduction in IOP lowering effect. No data on the level of circulating catecholamines after apraclonidine withdrawal are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.

An additive hypotensive effect has been reported with the combination of systemic clonidine and neuroleptic therapy. Systemic clonidine may inhibit the production of catecholamines in response to insulin-induced hypoglycemia and mask the signs and symptoms of hypoglycemia.

Since apraclonidine may reduce pulse and blood pressure, caution in using drugs such as beta-blockers (ophthalmic and systemic), antihypertensives, and cardiac glycosides is advised. Patients using cardiovascular drugs concurrently with apraclonidine ophthalmic solution 0.5% should have pulse and blood pressures frequently monitored. Caution should be exercised with simultaneous use of clonidine and other similar pharmacologic agents.