anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: In patients who require complex abdominal wall reconstruction (CAWR), the need for a bowel anastomosis could impact procedure choice and outcome. In this retrospective cohort study, we examine the effect of bowel anastomosis on complications and hernia recurrence.
METHODS: All patients who underwent CAWR between 2011 and 2021 by the senior author were reviewed in a retrospective cohort analysis. Patients were included if they met the above criteria. Patients were excluded if they did not undergo the above procedure or if they underwent a different procedure simultaneously. Univariate analysis was performed for patients who underwent bowel anastomosis, and multiple variable logistic regression analysis was performed with respect to overall complications.
RESULTS: A total of 264 patients underwent CAWR over a 10-year interval. A total of 41 patients underwent bowel anastomosis (16%), and 223 patients (84%) underwent CAWR without bowel anastomosis. Mean patient age was 55.50 ± 11.55 years. Mean patient body mass index was 32.36 ± 7.31 kg/m 2 . Mean follow-up time was 10.20 months. There was a significant difference in hernia repair etiology, with higher rates of recurrent hernia repair among patients receiving bowel anastomosis (odds ratio, 2.98; 95% confidence interval, 1.49-5.95; P = 0.0018). Acellular dermal matrix was used more frequently in patients who required a bowel anastomosis (odds ratio, 3.74; 95% confidence interval, 1.75-8.00; P = 0.0018). Major and minor complications were also significantly higher in this cohort. Regression analysis for overall complications revealed the presence of bowel anastomosis, fascial repair technique, and follow-up time as independent predictors of overall complications.
CONCLUSION: Bowel anastomosis performed at the time of CAWR significantly increased the rate of overall and major complications but did not predict hernia recurrence. Plastic surgeons should utilize this information in counseling patients and in deciding the most appropriate hernia repair technique.
Hypertension is one of the most important risk factors of ischemic cerebrovascular disease (ICVD), while various blood pressure variability (BPV) indices are immerging as novel prognostic indicators independent of the blood pressure level. However, the BPV profiles without hypertension have not been specifically observed. Considering the great importance of blood pressure management in ICVD, more research is needed to clarify whether and how BPV will increase the vascular risk in non-hypertensive patients with ICVD. This prospective cohort study will be helpful to invoke an early management of blood pressure in patients with ICVD before the clinical establishment of hypertension.

All eligible non-hypertensive patients hospitalized for ICVD will be consecutively enrolled in this cohort. Blood pressure measurements are obtained with ambulatory 24-hour blood pressure monitoring (ABPM) every 20 minutes during day-time (6:00-22:00) and every 30 minutes during night-time (22:00-6:00) at baseline and one year after the enrollment. The clinical, imaging and laboratory information will be collected at baseline. During an estimated 3-year follow-up, the vessel-related diagnostic or monitoring procedures, treatment, functional status and new vascular events will be recorded by web-based patients' self-reports and investigators' regular telephone visits.
This study aims to build upon the findings of the earlier randomized controlled trial (RCT) conducted at the Columbia University Medical Center (CUMC) comparing effects, both physiological and emotional, of the current standard method of encouraging contact between mothers and their babies in the NICU with the more specific approach of Family Nurture Intervention (FNI). In addition to receiving standard care, NICU families assigned to FNI received added intervention that focused on supporting the parents and facilitating emotional connection between mother and infant during the infant's NICU stay.

The investigators wish to conduct an effectiveness trial to evaluate if the family nurture intervention's findings can be replicated on a unit-wide level. This effectiveness trial will take place over two parts. There will be two groups; standard care (SC) and intervention (FNI). Phase 1 of the effectiveness study will evaluate the standard care (SC) group in the unit as a baseline measurement and point of comparison to determine if unit-wide FNI reproduces its prior findings (Phase 2). The standard care group (Phase 1) will receive the current standard of care in the NICU. In Phase 2, FNI will be implemented unit-wide, but infants born between 26 weeks and 0 days to 33 weeks 6 days gestation will be eligible to be enrolled into the study. In addition to receiving standard care, patients enrolled during phase 2 will receive added interventions from the trained FNI nursing staff. These added interventions will include supporting the parents and facilitating contact between mother and infant during their infant's NICU stay.
Traumatic brain injury (TBI) is a leading cause of disability worldwide, characterized by a complex interplay of primary and secondary injury mechanisms. Microglia, the resident immune cells of the central nervous system, play a crucial role in the inflammatory response following TBI. To review the current understanding of microglia-mediated neuroinflammation in TBI, exploring its dual nature as a protective and detrimental process. A comprehensive literature review was conducted using databases such as PubMed, Scopus, and Google Scholar. Relevant studies investigating the role of microglia in TBI were included. In the early stages of TBI, microglia exhibit a protective response, releasing cytokines and chemokines to promote neuronal survival and tissue repair. However, prolonged or excessive microglial activation can lead to neurotoxicity and exacerbate secondary injury. Microglia-mediated neuroinflammation involves complex signaling pathways, including Toll-like receptors, purinergic receptors, and the complement system. Microglia-mediated neuroinflammation in TBI is a double-edged sword. While acute microglial activation can promote repair, chronic or excessive inflammation contributes to neuronal damage and functional deficits. Understanding the temporal and molecular dynamics of microglial responses is crucial for developing therapeutic strategies to modulate neuroinflammation and improve outcomes after TBI.
Control of the HIV pandemic can only be achieved with the development of a safe and effective preventive HIV vaccine. A vaccine that will prevent HIV infection will elicit a strong immune response from both CD4 and CD8 cells. Recombinant adenovirus serotype vectors have been shown to elicit just such a response. The purpose of this study is to determine the safety and immunogenicity of the recombinant adenovirus serotype 5 preventive HIV-1 vaccine.

This study will last 18 to 24 months. Participants will be randomly assigned to one of four arms that will receive vaccine or placebo administered via intramuscular injection. Participants in Arms 1, 2, and 3 will all receive 3 injections. Participants in Arm 4 will receive one injection. For most participants, there will be 10 study visits in this study; for participants in Arm 4, there will be only 7 visits. For Arms 1, 2, and 3, study visits will occur at baseline and on Days 0, 14, 28, 42, 56, 168, 182,196, and 365. Participants in Arms 1, 2, and 3 will receive injections on Days 0, 28, and 168. For participants in Arm 4, study visits will occur at baseline and on Days 0, 14, 28, 56, 168 and 365. Participants in Arm 4 will receive one injection only, on Day 0. Participants will be asked to record their temperature and other side effects in a symptom log for 3 days after each injection. Risk reduction/pregnancy prevention counseling and physical exams will occur at all visits. At most visits, blood, urine, and oral swab collection will occur. Samples collected will be stored for future testing. HIV testing and pregnancy testing will occur at select visits. At Years 2, 3, 4, and 5, participants will be followed-up by telephone, e-mail, or study visit to collect vital status, and information about any development of significant disability or incapacity, hospitalizations, or congenital anomalies. At these follow-up visits, blood collection will be optional.
BACKGROUND: Endoscopic papillectomy (EP) is less invasive than surgery but procedure-related adverse events (AEs) still frequently occur. This study compared the benefits of EP using a new optimal endoCUT setting on the VIO (Erbe) electrosurgical unit (VIO-EP) with those using the conventional electrosurgical unit setting (ICC-EP, Erbe).
METHODS: This multicenter, retrospective, comparative cohort study included 57 patients who underwent VIO-EP and 91 who underwent ICC-EP. The primary outcome was occurrence of EP-related AEs. Secondary outcomes were pathological findings (the resection margins, the R0 resection, and residual lesions).
RESULTS: Pancreatitis tended to be less common in the VIO-EP group (5.3% vs. 9.9%, p = .248). Evaluation of computed tomography images showed that pancreatitis was confined to the pancreatic head in 77.8% of cases in the ICC-EP group and in 33.3% of those in the VIO-EP group. After exclusion of cases of delayed bleeding, pancreatitis tended to be less common in the VIO-EP group; this finding was not statistically significant (2.3% vs. 8.2%, p = .184). In pathological findings, residual lesions were significantly less common in the VIO-EP group.
CONCLUSIONS: The risks of pancreatitis and residual lesions after EP may be lower when the VIO electrosurgical unit is used with the optimal setting.
The proteasome inhibitors of this invention are peptide-based compounds with a short linear sequence of amino acids. A cyclic oxo or thio group is attached to the N-terminal amino acid. A protein-reactive electrophilic group such as an epoxyketone, an aziridinylketones, or a beta-lactone is attached to the C-terminal amino acid. Upon contact with a proteasome complex in a target cell, the electrophilic group reacts with a functional group in or near a binding pocket or active site of the proteasome, forming a covalent bond and thereby inactivating the proteasome. These and other proteasome inhibitors can be screened for inhibition activity and an ability to selectively eliminate senescent cells or cancer cells. Compounds with the requisite activity can be developed for the treatment of conditions such as osteoarthritis, ophthalmic disease, pulmonary disease, and atherosclerosis.
PROBLEM TO BE SOLVED: To obtain the subject composition extremely effective to proliferative acanthosis, dryness accompanied by erythema, and change of squamous properties, having effective activities for inhibiting dandruff and safe to the scalp by formulating a specific plant extract as an active ingredient. SOLUTION: This composition for a head is obtained by formulating one or more kinds selected from plant extracts of Kayu rapet (Parameria laevigata), Kemukus (Piper cubeba), Tempuyung (Sonchus arvensis L.), Belantas (Pluchea indica L.), Mesoyi (Massoia aromatica Becc.), Pule (Alstonia scholaris), Pulowaras (Alycia reindwartii Bl.) and Sintok (Cinnamomum sintoc Bl.). These eight kinds of plants are the plants growing in dry grassland, pasture, etc., in Indonesia. The formulating amount of the plant extract is 0.001-10 wt.% based on the total amount of the composition.
The application relates to two optimization methods of probe orientation during detection of a simulated traditional Chinese medicine pulse feeling device. The position of the pressure probe is optimized when the pulse feeling device detects, and the position, the direction and the basic pressure of the cun-guan-position pressure probe on the wrist are adjusted to record pulse wave signals with better or optimal quality. The existing methods for adjusting the orientation of the pressure probe are manually operated by a certain mechanism, and are driven by a servo motor wholly or partially. Whether manual adjustment or motor drive, the basis for the adjustment is the quality of the recorded pulse signal. Every time the orientation of the pressure probe is adjusted, a section of pulse signal needs to be recorded, and the quality of the pulse signal is evaluated. The pressure probe orientation adjustment is essentially a solution to the search optimization problem with recorded signal quality as an objective function. The application provides 2 kinds of pulse signal quality evaluation indexes, can well represent the quality of the pulse signal, and is efficient.
Patients will receive AZD2171 (cediranib maleate) 30mg by mouth once a day. Treatment may continue for as long as benefit is shown. Patients will undergo MRI and CT scan of the liver before beginning treatment, 3 days after the first dose of AZD2171, and after finishing course one. Patients will also undergo blood collection periodically for laboratory studies. Laboratory biomarker analysis, computed tomography, dynamic contrast-enhanced magnetic resonance imaging, and pharmacological study will be performed.
(1) Background: A healthy lifestyle has a protective role against the onset and management of asthma and chronic obstructive pulmonary disease (COPD). Therefore, combined lifestyle interventions (CLIs) are a potentially valuable prevention approach. This review aims to provide an overview of existing CLIs for the prevention and management of asthma or COPD. (2) Methods: A systematic literature search was conducted using PubMed, EMBASE, and PsycInfo. Studies were included if CLIs targeted at least two lifestyle factors. (3) Results: Among the 56 included studies, 9 addressed asthma and 47 addressed COPD management, with no studies focusing on prevention. For both conditions, the most prevalent combination of lifestyle targets was diet and physical activity (PA), often combined with smoking cessation in COPD. The studied CLIs led to improvements in quality of life, respiratory symptoms, body mass index/weight, and exercise capacity. Behavioural changes were only measured in a limited number of studies and mainly showed improvements in dietary intake and PA level. (4) Conclusions: CLIs are effective within asthma and COPD management. Next to optimising the content and implementation of CLIs, these positive results warrant paying more attention to CLIs for persons with an increased risk profile for these chronic respiratory diseases.
Step 1 of the intervention includes educational materials related to asthma. Step 2 includes electronic monitoring of adherence and a text messaging intervention personally tailored to the participant. Step 3 includes problem solving telehealth sessions with a trained clinician.
A method of combatting colour loss from a dyed material, the method comprising contacting the material with a composition comprising an amine salt of a carboxylic acid wherein the carboxylic acid has 4 to 10 carbon atoms. Preferably the material to be treated is keratinous fibres, especially wool or human hair. The preferred carboxylic acids are hexanoic and octanoic acids, preferably the triethanolamine or diethanolamine salts thereof. Compositions suitable for use with the methods are also disclosed. In a preferred embodiment the carboxylic acid is the triethanolamine salt of octanoic acid and the composition is applied to human hair as a shampoo which may contain anionic surfactants. In some embodiments the composition may be applied as part of a hair colouring process. In a further embodiment, the method is used to prevent colour loss from dyed wool textiles during a laundry process.
In the control group, intramuscular injection will be performed by the clinic nurse. All intramuscular injections will be performed by a single nurse and the ventrogluteal region will be used as the injection site. Patients will first fill out the Voluntary Information and Consent Form, and then the Descriptive Characteristics Form and State Anxiety Scale. After the injection site is assessed, the nurse will enter the tissue at a 90-degree angle and administer the medication slowly (1 ml/10 seconds). After removing the needle from the tissue, the nurse will apply pressure with dry cotton. After the procedure, the Numerical Pain Scale and State Anxiety Scale will be filled in within 1 minute.
PURPOSE:To obtain an excipient for direct tableting, having improved moldability, by spray-drying an aqueous solution or slurry of D-mannitol and starch hydrolyzate in a specific temperature range. CONSTITUTION:99.8-75pts.wt. D-mannitol and 0.2-25pts.wt. starch hydrolyzate are spray-dried at 110-150 deg.C exhaust heat temperature to give an excipient for direct tableting. If the aqueous solution or slurry of D-mannitol and the starch hydrolyzate has <=5 DE value [quality indication of starch sugar shows direct reducing sugar (as glucose)/total solid contentX100] are used, and the spray drying are carried out under the condition, the excipient for direct tableting having improved fluidity, disintegration properties, and moldability can be prepared without losing improved characteristics of D-mannitol. The excipient has d value at 5.33Angstrom  and 5.15Angstrom  in X-ray diffractionmetry as well, so correlation between moldability and the d value at 5.33A and 5.15A is ob served.
PURPOSE:To obtain an agent capable of preventing ascites of broiler and improving the rearing rate by using a specific quinone compound as an active component. CONSTITUTION:A quinone compound of formula (Y and Z are H, CH3 or together form one covalent bond of the double bond between C and C<2>; n is 1-11) is used as an active component of an agent for preventing ascites of broiler and an agent for improving the rearing rate of broiler. A feed for broiler is produced by compounding one or more kinds of the compound of formula I. The ascites of broiler is prevented and the rearing rate is improved by feeding a broiler of >=4 weeks old with one or more kinds of agents selected from the agent for preventing ascites of broiler, an agent for improving the rearing rate of broiler and the feed for broiler. When the agent is administered to a broiler having especially high oxygen demand, the energy requirement of the heart of the broiler is satisfied, the ascites is prevented and, as a result, the rearing rate is improved. The quinoline compound is preferably administered to a broiler at a rate of 0.05-50mg/kg body weight per day.
Systems and electronic displays with improved contrast even under bright-light conditions are provided. Such an electronic display may include a self-emissive pixel (e.g., OLED or μ-LED) with a corresponding liquid crystal switchable retarder pixel. A liquid crystal layer of the switchable retarder pixel may be tuned to an “on” state or an “off” state. In the “on” state, the switchable retarder pixel may allow outside light that enters the pixel to reflect back out of the pixel. This may add to the amount of light that appears to be emitted from that pixel. In the “off” state, the switchable retarder pixel may block the outside light that enters the pixel from reflecting back out of the pixel. This may reduce the amount of light that appears to be emitted from that pixel. Selectively controlling the switchable retarder pixels may allow for increased contrast even under bright-light conditions.
Studies have reported that the most common reason why patients require total knee arthroplasty before the age of 60 is a neglected or meniscectomized medial meniscus root tear. Overall, it has been noted that meniscal root repairs are cost effective and that the outcomes of meniscus root repairs are demonstrating patients have a significant improvement of their preoperative symptoms up to several years after surgery. Because most centers have only been preforming meniscus root repairs over the last five to ten years, we are now starting to recognize why some of the repairs do not function as well as others. The number one reason appears to be due to a postoperative meniscus extrusion. Meniscus extrusion has been seen in up to 50% of postoperative patients, and biomechanical studies have demonstrated that the cushioning effect of the medial meniscus does not function as well when there is a meniscus extrusion present. New biomechanical studies have demonstrated that the addition of a peripheral stabilization suture at the far posteromedial aspect of the medial tibial plateau helps to hold the meniscus better in the joint and that it also results in a significant decrease in load on the medial compartment. However, clinical studies are lacking to date as to whether a peripheral stabilization suture may or may not improve the protected function of the medial meniscus, decreased extrusion, and potentially lead to a less amount of progression of osteoarthritis in the medial compartment of the knee.

Therefore, this study strives to both assess the ability of a meniscus root repair to slow down the progression of arthritis of the medial compartment of patients with a 7-Tesla MRI scanner and also to concurrently assess the ability of the usage of a transtibial peripheral stabilization suture to decrease or eliminate meniscal extrusion. The importance of this study is that if the peripheral stabilization suture is noted to both decrease the progression of arthritis and also to decrease the meniscus extrusion, it will be a significant step forward in the treatment of these complex meniscal tears.
Placebo tablets will be administered for the first 4 weeks followed by a washout period of 2 weeks. After the washout period has been completed, losartan tablets will be administered for the next 4 weeks.
Cohort 1 will be guided through in-person meditation. Participants in all cohorts will be asked to attend one of the weekly sessions offered twice a week for the entirety of the 8 weeks for at least 1 hour. Participants will also be given access and asked to listen to virtual music-backed mindfulness guided meditations to listen to between in- person sessions.
Eligible participants received Fuzeon® (enfuvirtide) 90 milligram (mg) subcutaneously (SC) two times a day (bid) for 24 weeks plus new protease inhibitor (PI) (darunavir/ritonavir) plus other investigator-choice antiretrovirals (ARVs). Participants selected their preferred injection device among the following three options: 27 gauge (G) ½" needle/syringe, 31G 8 millimeter (mm) needle/syringe or Biojector 2000 (B2000) needle-free injection device (NFID).
The invention relates to a traditional Chinese medicine combination for treating eczema and belongs to the technical field of traditional Chinese medicine. An oral medicine of the traditional Chinese medicine combination is composed of the following traditional Chinese medicine ingredients (by weight): 5-10 parts of Scutellaria baicalensis, 5-15 parts of cortex phellodendri, 5-15 parts of rhizoma atractylodis, 10-15 parts of sophora flavescens, 10-20 parts of plantain herb, 5-15 parts of Polyporus umbellatus, 15-20 parts of rhizoma smilacis glabrae, 5-15 parts of seed of Job's tears, 10-20 parts of dandelion and 5-10 parts of liquorice. A drug for external use is composed of the following traditional Chinese medicine ingredients (by weight): 4-6 parts of sophora flavescens, 3-5 parts of folium artemisiae argyi, 2-5 parts of common cnidium fruit and 1-3 parts of fructus xanthii. A preparation method of the above traditional Chinese medicine combination for treating eczema comprises the following steps: decocting the oral medicine with water for twice according to a conventional decoction mode, and merging two medicinal filtrates; and decocting the drug for external use with water and scrubbing affected parts with the liquid medicine. The traditional Chinese medicine combination is a pure traditional Chinese preparation, is nontoxic and has no side effect. By combined treatment of the oral medicine and the drug for external use, curative effect is good and cure rate is high.