anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIM: To determine variations in allele and genotype frequencies between keratoacanthoma (KA) and common warts (CW), compared with the control group, in three single nucleotide polymorphisms (SNPs) within the TLR2, TLR3, and TLR9 genes.
METHODS: This case-control study involved samples from 161 patients with KA, 152 patients with CW, and 469 controls. DNA was isolated from formalin-fixed paraffin-embedded tissue sections. Three SNPs - rs4696480 in TLR2, rs7657186 in TLR9, and rs35213 in TLR3 - were genotyped with TaqMan Genotyping Assays on the 7500 Real-Time PCR System.
RESULTS: TLR2 rs4696480 and TLR3 rs7657186 were significantly overrepresented in KA and CW compared with controls (P<0.001). The association was stronger for CW than for KA, as evidenced by higher frequencies of the A allele and AA genotype for rs4696480. Both KA and CW patients had higher frequencies of the G allele and GG genotype for rs7657186 than controls. rs7657186 was moderately associated with KA and CW, with the G allele and GG genotype being more prevalent in CW cases, where no AA homozygotes were found.
CONCLUSION: Genetic variants in TLR2 (rs4696480) and TLR3 (rs7657186) genes may affect KA and CW development, influencing immune responses and susceptibility to these skin lesions. Further research is required to elucidate TLR expression patterns and their role in KA development.
Reading skills and developmental dyslexia, characterized by difficulties in developing reading skills, have been associated with brain anomalies within the language network. Genetic factors contribute to developmental dyslexia risk, but the mechanisms by which these genes influence reading skills remain unclear. In this preregistered study (https://osf.io/7sehx), we explored if developmental dyslexia susceptibility genes DNAAF4, DCDC2, NRSN1, and KIAA0319 are associated with brain function in fluently reading adolescents and young adults. Functional MRI and task performance data were collected during tasks involving written and spoken sentence processing, and DNA sequence variants of developmental dyslexia susceptibility genes previously associated with brain structure anomalies were genotyped. The results revealed that variation in DNAAF4, DCDC2, and NRSN1 is associated with brain activity in key language regions: the left inferior frontal gyrus, middle temporal gyrus, and intraparietal sulcus. Furthermore, NRSN1 was associated with task performance, but KIAA0319 did not yield any significant associations. Our findings suggest that individuals with a genetic predisposition to developmental dyslexia may partly employ compensatory neural and behavioral mechanisms to maintain typical task performance. Our study highlights the relevance of these developmental dyslexia susceptibility genes in language-related brain function, even in individuals without developmental dyslexia, providing valuable insights into the genetic factors influencing language processing.
Patients will have imaging studies (modality and frequency per treating physician, however at a minimum frequency of every 12 weeks) alone or in conjunction with STMs (frequency determined by treating physician). Patients will continue with usual care disease monitoring for up to 312 weeks in the absence of disease progression.
PURPOSE: A triterpenoid compound having activity of suppressing virus activity is provided to use as therapeutic agent to virus-relating disease. CONSTITUTION: A pharmaceutical composition for treating and/or preventing diseases caused by virus infection comprises a compound of chemical formula I, its isomer or pharmaceutically acceptable salt, their solvate, hydrate or protrude as an active ingredient. In the chemical formula I, R1, R2, R3, R4, R5, R6, R7, and R8 are independently hydrogen, hydroxyl, aldehide, ketone, carboxyl, amine, C1-C6 alkyl or C1-C6 alkoxy. The compound of chemical formula I is lupeol or betulinic aldehyde. The compound of chemical formula I is derived from Alnus japonica. The virus is avian influenza virus.
ARM B: Azacitidine 75 mg/m\^2 /day by vein over 15 - 30 minutes daily for 5 days (Days 1 - 5). Courses repeated every 3 to 8 weeks.
Newly diagnosed patients with colon, rectum, liver, pancreas or lung cancer, malignant melanoma, breast or other gynecological cancers, prostate, kidney, bladder or thyroid gland cancer, non-Hodgkin lymphoma or leukemia recruited approximately 6 months after diagnosis and followed up to 2 years post-diagnosis. No intervention.
Schizophrenia is a polygenic complex disease with a heritability as high as 80 %, yet the mechanism of polygenic interaction in its pathogenesis remains unclear. Studying the interaction and regulation of schizophrenia susceptibility genes is crucial for unraveling the pathogenesis of schizophrenia and developing antipsychotic drugs. Therefore, we developed a bioinformatics method named GRACI (Gene Regulation Analysis based on Causal Inference) based on the principles of information theory, a causal inference model, and high order chromatin 3D conformation. GRACI captures the interaction and regulatory relationships between schizophrenia susceptibility genes by analyzing genotyping data. Two datasets, comprising 1459 and 2065 samples respectively, were analyzed, and the gene networks from both datasets were constructed. GRACI showcased superior accuracy when compared to widely adopted methods for detecting gene-gene interactions and intergenic regulation. This alignment was further substantiated by its correlation with chromatin high-order conformation patterns. Using GRACI, we identified three potential genes-KCNN3, KCNH1, and KCND3-that are directly associated with schizophrenia pathogenesis. Furthermore, the results of GRACI on the standalone dataset illustrated the method's applicability to other complex diseases. GRACI download: https://github.com/liuliangjie19/GRACI.
The invention relates to amphiphilic block or graft copolymers comprising radio-opaque hydrophobic blocks and having a high heavy metal content. Said copolymers consist of, or are formed by, the structural units (A) = [C(R1R2)-CHR3] and (B) = [C(R4R5)-CHR6], the proportion thereof being at least 70 wt. %. The blocks poly(A) and blocks poly(B) respectively contain a repeating unit consisting of two carbon atoms, at least one of said atoms carrying a substituent. Block A is a hydrophilic block carrying at least one hydrophilic substituent per C2 carbon unit, while block B is a hydrophobic block, the C2 carbon unit thereof carrying at least one hydrophobic radical. Block B also carries a high proportion of covalently bonded heavy metals. The inventive copolymers can be used to produce micelle suspensions that are suitable as x-ray contrast agents.
In the present invention, there are disclosed HIV protease novel inhibitors comprising substituted borane, carborane or metallacarborane clusters having 6 to 12 boron atoms in each individual cluster, wherein charge of each individual borane, carborane or metallacarborane cluster is 0. -1 or -2. The borane, carborane or metallacarborane clusters are substituted on periphery with groups increasing interaction energy between HIV protease and the inhibitor, wherein number of the borane, carborane or metallacarborane clusters in the inhibitor molecule ranges from 1 to 9, wherein the carborane clusters in the metallacarborane inhibitors are coordinated to a transient metal atom being selected from the group consisting of Co, Fe, Ni and Ru. Disclosed is also the use of these inhibitors in vitro as well as in vivo. Introduction of the derivative of the boron cluster compounds as a novel structural element provides inhibition properties for HIV protease and mutants thereof that are resistant to other inhibitors. Low toxicity, stability and biocompatibility along with high efficiency make these boron compounds suitable for AIDS therapy.
Transplantation of pluripotent stem cell-derived cardiomyocytes is a novel promising cell-based therapeutic approach for patients with heart failure. However, engraftment arrhythmias are a predictable life-threatening complication and represent a major hurdle for clinical translation. Thus, we wanted to experimentally study whether impulse generation by transplanted cardiomyocytes can propagate to the host myocardium and overdrive the recipient rhythm. We transplanted human induced pluripotent stem cell-derived cardiomyocytes expressing the optogenetic actuator Bidirectional Pair of Opsins for Light-induced Excitation and Silencing (BiPOLES) in a guinea pig injury model. Eight weeks after transplantation ex vivo, Langendorff perfusion was used to assess electrical coupling. Pulsed photostimulation was applied to specifically activate the engrafted cardiomyocytes. Photostimulation resulted in ectopic pacemaking that propagated to the host myocardium, caused non-sustained arrhythmia, and stimulated the recipient heart with higher pacing frequency (4/9 hearts). Our study demonstrates that transplanted cardiomyocytes can (1) electrically couple to the host myocardium and (2) stimulate the recipient heart. Thus, our results provide experimental evidence for an important aspect of engraftment-induced arrhythmia induction and thereby support the current hypothesis that cardiomyocyte automaticity can serve as a trigger for ventricular arrhythmias.
PURPOSE: A composition containing miRNA or antisense nucleic acid molecules for preventing grey hair or improving a skin whitening effect is provided to regulate the expression of genes expressing tyrosinase, tyrosinase-related proteins, and melan-A. CONSTITUTION: A composition for regulating the expression of pigmentation-related genes contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among base sequences of sequence number 1, and contains 15-22 continuous base sequences including ugaaaug. The pigmentation-related genes express tyrosinase, tyrosinase-related protein 1, or melan-A. A method for screening a material which regulates the expression of the pigmentation-related genes among test materials comprises: a step of transfectioning the miRNA of sequence number 1 or antisense nucleic acid molecules of sequence number 2 into cells; a step of treating the test materials to the cells; and a step of identifying if the test materials promote or suppress the expression of the pigmentation-related genes. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
The present invention relates to liposome for local skin and preparation thereof. Imiquimod or a derivative thereof, a fat phase, acid and alkali solution and a rack agent are prepared into liposome of imiquimod or a derivative thereof. The liposome for local skin can be used for treating virus infection, wart, eczema, etc. of the skin. The liposome for local skin can mainly be used for treating melanoma, basal cell carcinoma and other dermatoma diseases. The liposome for local skin can also be used for treating many other diseases. Imiquimod liposome and cream are applied to the par. Aff of animals which have the melanoma; after 4 weeks, the death rate/the death time is used as the assessment index; a preliminary result shows that after 29 days, the death rate of a control group is 74%, the death rate of a cream group is 70%, and the death rate of a liposome group is 38%.
PURPOSES: This study explored the association between the nutritional status and survival outcomes after pancreatic cancer surgery and reconsidered surgical indications in octogenarians.
METHODS: Three hundred and ninety-three consecutive pancreatic cancer patients who underwent resection were analyzed and grouped according to age (< 70 years old; septuagenarians [70-79 years old], and octogenarians [80-89 years old]). The Charlson age comorbidity index and nutritional parameters were recorded. Survival outcomes and their association with nutritional parameters and prognostic factors were examined.
RESULTS: The overall survival was worse in the octogenarians than in other patients. The median overall survivals in the < 70 years old group, septuagenarians, and octogenarians were 27.2, 26.4, and 15.3 months, respectively (P = 0.0828). DUPAN-2 ≥ 150 U/mL, borderline resectable/unresectable tumors, blood loss volume ≥ 500 mL, and blood transfusion were predictors of the overall survival among octogenarians. Nutritional parameter values were worse in the octogenarians than in other patients. The octogenarian age group was not an independent predictor of postoperative complications in a univariate analysis.
CONCLUSIONS: Survival outcomes were poor in octogenarians. However, an age ≥ 80 years old alone should not be considered a contraindication for pancreatic cancer surgery. The maintenance of perioperative nutritional status is an important factor associated with the survival.
The placebo used for this study is 0.9% Sodium Chloride (NaCl). Participants that are randomized to the control arm will receive a placebo injection of 0.1ml 0.9% NaCl, which is the same volume and has the same colour as the suspended BCG vaccine.
INTRODUCTION AND OBJECTIVE: The aim of this study was to enhance the understanding of the tensor vastus intermedius (TVI), a recently recognized addition to the quadriceps femoris muscle group, by conducting a systematic literature review with empirical cadaveric research to provide comprehensive data on its anatomical features, including dimensions, topography, variations, and prevalence.
MATERIAL AND METHODS: An exhaustive literature review was conducted using medical databases such as PubMed, MEDLINE, and Scopus. This review was complemented by original cadaveric research involving 30 autopsied adult bodies, encompassing 60 lower limbs, to empirically investigate the TVI's anatomical characteristics.
RESULTS: The TVI was consistently identified in the medial aspect between the vastus lateralis (VL) and vastus intermedius (VI) in all examined cases. Detailed documentation covered its anatomical specifics, e.g. location, origin, and fascial connections, categorized using the criteria of Grob et al. Measurements of the muscle belly - length, width, and thickness - showed no significant lateral differences, but revealed gender-based disparities in TVI's size.
CONCLUSIONS: The review not only confirms the consistent presence of the TVI, but also addresses the discrepancies in existing literature about its anatomical distribution and dimensional metrics. The observed methodological variations in previous studies underscore the need for standardized research methodologies in muscle anatomy. This in-depth review analysis significantly contributes to a deeper understanding of TVI, proving particularly beneficial for professionals in rehabilitation and related medical fields.
Parkinson's disease (PD) is a central nervous system disease that results in deficits in motor activities such as walking. Gait speed and step length are frequently reduced. Aquatic physiotherapy serves as a form of complementary treatment to promote improvements in the disease's motor symptoms. The purpose of this study was to examine the effect of an aquatic physiotherapy training program on gait in individuals with PD. This is an interventional clinical study in which a group of participants with PD participated in an assessment on the ground of their usual and maximum gait speed using the 10-m Walk Test and complex activities related to gait using the Dynamic Gait Index (DGI) at baseline and 12 weeks of an aquatic physiotherapy intervention, twice a week for 50 min. For statistical analysis, the paired t-test and the Wilcoxon test were used. The study included 10 individuals with PD, in the intermediate stage of PD - H&Y 2 (60%) and 3 (40%), of both sexes with a mean age of 65.8 ± 13.69 years. There was a significant increase in usual gait speed (p = 0.001) and in the DGI score (p = 0.05), but there was no improvement in maximum gait speed (p = 0.119). The aquatic physiotherapy exercise program improved habitual gait speed and the performance of complex activities related to gait in this group individuals with PD.
The invention discloses an intestinal medicine-release preparation taking a thymopertin PEGylation derivative as an active composition and application. The oral preparation of the thymopertin PEGylation derivative employs an enteric form, so that the degradation of the preparation caused by pepsin is avoided. Thymopertin linked with polyethylene glycol is increased in molecular weight, the kidney clearance is reduced and the in-vivo retention time is increased. Thymopertin linked with polyethylene glycol is degraded by in-vivo protease and amino-peptidase with a reduced speed and is retained in blood for an increased time, so that the treatment effect is improved. Injection is replaced by oral administration or a suppository, the compliance of patients is increased, and the treatment cost is reduced. The polyethylene glycol derivative of thymopertin can be used as an immunomodulator.
The invention provides a specific sgRNA for targeted knockout of a human OC-2 gene and application thereof. The invention takes OC-2 gene on human genome as target, designs and obtains sgRNA molecule capable of efficiently, specifically and accurately targeting human OC-2 gene through a series of screening and analysis, as shown in SEQ ID No. 2-4. The invention also provides a lentiviral vector and a lentivirus containing the specific sgRNA. Meanwhile, the invention also provides a method for knocking out human OC-2 gene by using CRISPR-Cas9 system, and a stable OC-2 gene knock-out strain can be obtained. The specific sgRNA can block the expression of OC-2 gene in ovarian cells through a CRISPR/Cas system, obviously inhibit the proliferation, migration and invasion capacities of ovarian cancer cells, provide a new direction and thought for the research and clinical treatment of ovarian cancer, and have good application prospect.
A bifidobacterium longum subsp. longum i772, an isolation and purification method therefor and use thereof. The strain has been deposited in the China General Microbiological Culture Collection Center, with the deposit number of CGMCC NO. 19856. The bifidobacterium longum subsp. longum is obtained by enriching, screening and continuously purifying a target strain in the feces of breast-feeding infants or young children. Compared with the existing bifidobacterium longum subsp. longum, the screened bifidobacterium longum subsp. longum has the functions of regulating the intestinal flora balance and relieving the liver injury caused by alcohol. The strain is used for preparing beverages, foods, medicines or probiotic products having an intestinal regulation function.
PURPOSE:To provide a cosmetic having excellent moistening effect, emollient effect and skin-activation effect and high agestability, by compounding a neutral lipid produced by a mold belonging to Mortierella genus. CONSTITUTION:A mold belonging to Mortierella genus (e.g. Mortierella isabellina, Mortierella vinacea, Mortierella nana, etc.) is cultured in a medium containing glucose, saccharose, etc., as carbon source, urea, yeast extract, peptone, etc., as nitrogen source, potassium dihydrogen phosphate, sodium chloride, etc., as inorganic salt and other minor components as nutrient sources. The produced microbial cells are added with an organic solvent, disintegrated and extracted. The resultant neutral liquid is added to a cosmetic such as facial cosmetic, hair cosmetic, make-up cosmetic, aromatic cosmetic, etc., in an amount of preferably about 0.001-30wt% based on the total cosmetics.
Patients receive methylphenidate PO BID for up to 2 weeks in the absence of disease progression or unacceptable toxicity. Patients also complete physical activity consisting of walking and resistance exercise over 25-40 minutes QD 4 days a week. After 2 weeks, patients may continue methylphenidate at the discretion of the treating physician for up to 12 weeks in the absence of disease progression or unacceptable toxicity.
Stage 1 Safety Run-in Phase (SRP): Approximately 12 participants will receive cobimetinib 60 milligrams (mg) orally once daily for Days 1-21 with atezolizumab 840 mg and bevacizumab 5 milligrams per kilogram (mg/kg) administered by IV infusion on Days 1 and 15 of each 28-day cycle. Atezolizumab will be administered first, followed by bevacizumab, with a minimum of 60 minutes between dosing. Upon determination of the safety and tolerability of the treatment regimen, the study will proceed to Stage 2: dose expansion phase. If the results from the safety run-in phase require dose reduction in cobimetinib, then an additional Stage 1 cohort will be opened. Treatment will continue until the participant has disease progression according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1), unacceptable toxicity, death, participant or physician decision to withdraw, or pregnancy, whichever occurs first.
BACKGROUND: The traditional surgical procedures for upper lumbar disc herniation (ULDH) usually lead to frequent complications. We aim to investigate the clinical efficacy of the unilateral biportal endoscopy (UBE) technique in treating upper lumbar disc herniation (ULDH).
METHODS: From January 2020 to December 2021, the clinical data of 28 patients with ULDH treated with the UBE technique were collected and analyzed for surgery time under UBE, postsurgical drainage, postsurgical hospital stay, and complications. The clinical efficacy was evaluated according to the modified MacNab score, Oswestry disability index (ODI), and visual analogue scale (VAS) of low back pain and lower limb pain before the surgery; one week, one month, and three months after the surgery; and at the last follow-up.
RESULTS: All patients underwent the UBE surgery successfully. The surgery time under UBE for non-fusion cases was 47.50 ± 11.84 min (monosegment) and 75.00 ± 20.66 min (two segments), while that for fusion cases was 77.50 ± 21.02 min. The postsurgical drainage for non-fusion cases was 25.00 ± 13.94 mL (monosegment) and 38.00 ± 11.83 mL (two segments), while that for fusion cases was 71.25 ± 31.72 mL. The postsurgical hospital stay was 8.28 ± 4.22 days. The follow-up time was 15.82 ± 4.54 months. The VAS score for each time period after the surgery was significantly lower (P < 0.05), while the ODI was significantly higher than that before the surgery (P < 0.05). According to the modified MacNab scoring standard, the ratio of excellent to good was 96.43% at the last follow-up. Two patients experienced transient numbness and pain in their lower limbs and no activity disorder after the surgery, and they recovered after conservative treatment.
CONCLUSIONS: The clinical effect of UBE technique in treating ULDH was reliable. According to the needs of the disease, the interlaminar approach or paraspinal approach of the UBE technique was selected. This technique took into account the effect of treatment, achieved the purpose of minimal invasiveness, and did not require special instruments. Therefore, it has the potential for clinical application.