anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a high quality image matching a monitor screen and having high resolution by fetching detailed images and residual images from a storage and processing the images by applying the inverse of decomposition and conversion. CONSTITUTION: A reading-out device 1 and a processing module 7 are connected to a workstation 11 and a related review console 12 which perform off-line processing. Namely, in a high-speed interactive off-line processing method, a radiographic image is stored after the image is converted into a series of decomposed images containing detailed images and residual images. Then the decomposed images are fetched from the storage to a predecided resolution level and the fetched decomposed images are processed by taking a series of processing parameters into consideration. Namely, a processed image is reproduced by inversely applying decomposition and conversion performed on the processed images and residual images. The processed image is displayed for evaluation.
BACKGROUND: Prior MRI studies on vestibular migraine (VM) have revealed abnormalities in static regional intrinsic brain activity (iBA) and dynamic functional connectivity between brain regions or networks. However, the temporal variation and concordance of regional iBA measures remain to be explored.
METHODS: 57 VM patients during the interictal period were compared to 88 healthy controls (HC) in this resting-state functional magnetic resonance imaging (fMRI) study. The dynamics and concordance of regional iBA indices, including amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), were examined by utilizing sliding time-window analysis. Partial correlation analyses were performed between clinical parameters and resting-state fMRI indices in brain areas showing significant group differences.
RESULTS: The VM group showed increased ALFF and ReHo dynamics, as well as increased temporal concordance between ALFF and ReHo in the bilateral paracentral lobule and supplementary motor area relative to the HC group. We also found decreased ReHo dynamics in the right temporal pole, and decreased ALFF dynamics in the right cerebellum posterior lobe, bilateral angular gyrus and middle occipital gyrus (MOG) in the VM group compared with the HC group. Moreover, a positive correlation was observed between ALFF dynamics in the left MOG and vertigo disease duration across all VM patients.
CONCLUSION: Temporal dynamics and concordance of regional iBA indices were altered in the motor cortex, cerebellum, occipital and temporoparietal cortex, which may contribute to disrupted multisensory processing and vestibular control in patients with VM. ALFF dynamics in the left MOG may be useful biomarker for evaluating vertigo burden in this disorder.
PROBLEM TO BE SOLVED: To prepare a vitamin K supplementary food containing vitamin K at a high concentration and a food for preventing or treating osteoporosis capable of preventing or treating the osteoporosis. SOLUTION: This vitamin K supplementary food comprises a bacterium, containing vitamin K at a high concentration and belonging to the genus Lactococcus or the genus Leuconostoc. The bacterium belonging to the genus Lactococcus is Lactococcus lactis ssp. lactis or Lactococcus lactis ssp. cremoris or the bacterium belonging to the genus Leuconostoc is Leuconostoc lactis. The food for preventing or treating osteoporosis comprises the vitamin K supplementary food.
A method and system for generating a treatment plan are disclosed herein. A computing system receives a plurality of dose volume histograms for a plurality of patients and a plurality of volumetric dose distributions corresponding to the plurality of dose volume histograms. The computing system generates a volumetric dose prediction model using a neural network by learning, by the neural network, a relationship between a plurality of dose volume histograms for the plurality of patients and the corresponding plurality of volumetric dose distributions. The computing system receives a candidate dose volume histogram for a target patient. The computing system infers, via the volumetric dose prediction module, a volumetric dose prediction distribution matching the candidate dose volume histogram. The computing system generates a recommendation based on the inferred volumetric dose prediction distribution.
The sample size of the research was calculated using G\*Power 3.1.9.4 software as a minimum of 34 with 95% power, 0.01 alpha, and 0.9 effect size. The sample size was planned as experimental (n=34) and control (n=34) groups. To ensure the equality of the samples in both groups, a simple randomization method was used, where pregnant women with odd hospital protocol numbers will be included in the experimental group and those with even numbers will be included in the control group. Pregnant women who are admitted for pre-cesarean section care will be informed about the study, and their voluntary consent will be obtained both in written and verbal form. Pre-tests will be administered to both the experimental and control groups at 08:00, and blood samples will be taken to measure cortisol levels. Subsequently, an intervention will be applied to those in the experimental group, while those in the control group will receive routine nursing care. At 09:00, post-tests will be administered to both the experimental and control groups, and blood samples will be taken again to measure cortisol levels. The pre-test and post-test results, as well as the mean cortisol levels, will be compared between the experimental and control groups.
The utility model discloses a multifunctional bed head, including head of a bed body, still include a display screen, No. two display screens, wireless communication module, singlechip, user side, backend server, head of a bed body one side sliding connection has the fixed block, fixed block upper end fixed mounting has the support, head of a bed body opposite side is provided with temperature sensor, humidity transducer, No. one display screen, No. two display screens, megaphone and camera are installed to head of a bed body front side gomphosis, through internet access between wireless communication module, user side, the backend server, wireless communication module, temperature sensor, humidity transducer, a display screen, No. two display screens, megaphone, camera and singlechip signal connection. The utility model has the advantages of can inquire the expense of being in hospital, can long-range spy, can inquire in real time patient health, can prevent the state of an illness from worsening, can collect fee by oneself.
DOSAGE MUST BE INDIVIDUALIZED (SEE INDICATIONS). NADOLOL AND BENDROFLUMETHIAZIDE TABLETS MAY BE ADMINISTERED WITHOUT REGARD TO MEALS.

Bendroflumethiazide is usually given at a dose of 5 mg daily. The usual initial dose of nadolol is 40 mg once daily whether used alone or in combination with a diuretic. Bendroflumethiazide in nadolol and bendroflumethiazide tablets is 30 percent more bioavailable than that of 5 mg bendroflumethiazide tablets. Conversion from 5 mg bendroflumethiazide tablets to nadolol and bendroflumethiazide tablets represents a 30 percent increase in dose of bendroflumethiazide.

The initial dose of nadolol and bendroflumethiazide tablets may therefore be the 40 mg/5 mg tablet once daily. When the antihypertensive response is not satisfactory, the dose may be increased by administering the 80 mg/5 mg tablet once daily.

When necessary, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure.
This study aimed to systematically review the literature to evaluate the effectiveness of virtual reality in reducing anxiety and pain in patients undergoing third molar surgeries. Clinical trials evaluating patients who used virtual reality (VR) compared with no VR in the management of pain or anxiety after third molar extractions were included. A literature search was conducted in five electronic databases to identify relevant articles: Medline (PubMed interface), Web of Science, Virtual Health Library, Embase, and Scopus. There were no restrictions on the time or language of publication. The risk of bias was assessed using the Cochrane Risk of Bias Tool for Randomised Trials (RoB 2.0). A total of six studies were included in the qualitative analysis and three in the quantitative analysis. The results of the meta-analyses on anxiety revealed that patients in the intervention group before VR already showed less anxiety compared to those in the control group (-0.28 [-0.44 to -0.13, 95%CI] I²=24.51%. In the post-intervention evaluation, the group that received VR remained with a lower level of anxiety and a slight reduction compared to the pre-intervention. (-0.34 [-0.49 to -0.19, 95%CI] I²=36.61%. Virtual reality can be a clinical resource in dental care because it seems to cause a small reduction in anxiety, and with still uncertain results in the reduction of postoperative pain in extractions of third molars.
Objective: To analyze the clinical efficacy of intrathyroid thymic carcinoma (ITTC). Methods: This study retrospectively analyzed the clinical data of 21 patients with ITTC diagnosed and treated at the First Affiliated Hospital of Zhengzhou University from January 2018 to July 2023, including 9 males and 12 females, with a median age of 52 years (40-60 years old). Results: There is a correlation between the maximum diameter of the tumor (≥40 mm) and lymph node metastasis (P=0.044). Seventeen patients received surgical treatment, and 4 patients only received chemotherapy. During the follow-up period, a total of 4 patients experienced death or progression, with a 2-year mortality or progression free survival rate of 74.8%. Conclusions: The prognosis of ITTC is good, and surgical treatment is the preferred treatment option, lymph node metastasis is significantly correlated with prognosis. The radiotherapy and chemotherapy of ITTC need to be determined based on the patient's condition.
333,155. I. G. Farbenindustrie Akt.- Ges. Feb. 5, 1929. Addition to 305,475. Medicines for internal use. - The process described in the parent Specification for obtaining active substances from the whole hypophysis is modified by substituting for the hydrolysis by means of acid or alkali a treatment with a ferment; either autolysis or digestion with an added ferment being employed. According to examples (1) fresh whole hypophysis is treated with a suspension of succus caricae papayas in water containing toluene, the mass is acidified with hydrochloric acid, allowed to stand in an incubator for four hours and then for a short time at room temperature, and centrifuged to obtain a clear liquid which is neutralized to precipitate albuminates and may be further treated with a water-soluble organic solvent to precipitate remaining ballast substances; (2) fresh whole hypophysis is twice agitated for periods of three hours with water containing a little cresol and centrifugal to obtain filtrates containing the hormone of the posterior lobe, and the remaining solid is steeped in water for three days at 35‹ C. to obtain a solution of the anterior lobe hormone from which ballast substances precipitate on adjustment of the hydrogen ion concentration and which may be further purified as in the first example; (3) fresh whole hypophysis is twice treated for periods of two hours at refrigerator temperature with water containing toluene to obtain solutions of the posterior lobe hormone, and the residue is treated with succus caricae papayae at pH 5 to 6.5 for several hours at 38‹ C., centrifuged and the liquid further purified as in the first example.
The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold ('HPPS') nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a- helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.
Childhood obesity (CO) negatively affects one in three children and stands as the fourth most common risk factor of health and well-being. Clarifying the molecular and structural modifications that transpire during the development of obesity is crucial for understanding its progression and devising effective therapies. The study was indeed conducted as part of an ongoing CO treatment trial, where data were collected from children diagnosed with CO before the initiation of non-drug treatment interventions. Our primary aim was to analyze the biochemical changes associated with childhood obesity, specifically focusing on concentrations of lipids, lipoproteins, insulin, and glucose. By comparing these parameters between the CO group (n = 60) and a control group of healthy children (n = 43), we sought to elucidate the metabolic differences present in individuals with CO. Our biochemical analyses unveiled lower LDL (low-density lipoproteins) levels and higher HDL (high-density lipoproteins), cholesterol, triglycerides, insulin, and glucose levels in CO individuals compared to controls. To scrutinize these changes in more detail, we employed Fourier transform infrared (FTIR) spectroscopy on the serum samples. Our results indicated elevated levels of lipids and proteins in the serum of CO, compared to controls. Additionally, we noted structural changes in the vibrations of glucose, β-sheet, and lipids in CO group. The FTIR technique, coupled with principal component analysis (PCA), demonstrated a marked differentiation between CO and controls, particularly in the FTIR region corresponding to amide and lipids. The Pearson test revealed a stronger correlation between biochemical data and FTIR spectra than between 2nd derivative FTIR spectra. Overall, our study provides valuable insights into the molecular and structural changes occurring in CO.
PURPOSE:To secure safety and to enhance fixability, by coating the surface of an artificial medical material composed of a shape memory alloy with a substance having bone replaceability such as beta-TCP. CONSTITUTION:A bone bonding material 1 is composed of a shape memory alloy and a plurality of pins 2 are provided to the under surface thereof in a protruding state. The outer surface of the bone bonding material 1 is coated with a substance having bone replaceability such as beta-TCP 3. The bone bonding material 1 is preliminarily subjected to shape memory processing so as to be contracted by a predetermined amount in the long axis direction at arbitrary temp. in the vicinity of 30-40 deg.C. When a fractured bone 5 is treated, the bone bonding material 1 is applied to the side surface of the bone 5 across the fracture part 6 and the pins 2 are embedded in the bone 5. Heat is applied to the bone bonding material 1 so as to reach the temp. restoring the memory shape and the bone bonding material 1 restores the memory shape to certainly fix the fracture part 6. The outer surface of the bone bonding material is coated with beta-TCP 3 having bone replaceability and beta-TCP 3 is rapidly replaced with a bone and the bone bonding material 1 is certainly fixed to the bone 5.
A method for automatically generating notes summarizing a conversation between a patient and a healthcare provider is disclosed. The workstation is provided with means for rendering an audio recording of the dialog, and a display for displaying a text recording of the audio recording obtained from the speech-to-text engine. The display of the workstation includes a first text entry area for displaying the text entries and a second note area for simultaneously displaying elements of notes summarizing a conversation. With the aid of a trained machine learning model, words or phrases in a word record relating to a medical topic related to a patient are extracted. The extracted word or phrase is highlighted in the text record and displayed in the note area. Links or mappings between the extracted words or phrases in the note area and portions of the word record from which the extracted words or phrases originated are provided, thereby enabling verification of the origin and accuracy of the extracted words or phrases in the note area by a user of the workstation.
Current childhood obesity treatment programs do not address medically underserved populations or settings where all members of an interdisciplinary team may not exist-either within one organization or within the community. In this paper, we describe the use of a community-academic partnership to iteratively adapt Epstein's Traffic Light Diet (TLD), into Building Healthy Families (BHF), a community-placed evidence-based pediatric weight management intervention (PWMI) and evaluate its effectiveness in reducing BMI z scores. Nine cohorts of families completed BHF. Participants included children aged 6-12 years with obesity (M = 9.46, SD = 1.74). The Framework for Reporting Adaptations and Modifications-Expanded guided our classification of modifications across BHF cohorts. Using the FRAME reporting structure, the changes that were documented were (1) planned and occurred pre-implementation, (2) based on decisions from local stakeholders (e.g., school administrator, members of the implementation team), and (3) specific to changes in content and context-with a focus on implementation and potential for local scale-up. The nature of the adaptations included adding elements (whole of family approach), removing elements (calorie counting), and substituting elements (steps for minutes of physical activity). Across 9 cohorts, 84 families initiated the BHF program, 69 families successfully completed the 12-week program, and 45 families returned for 6-month follow-up assessments. Results indicated that the BMI z score in children was reduced by 0.31 ± 0.17 at 6 months across all cohorts. Reduction in BMI z score ranged from 0.41 in cohort 4 to 0.13 in cohort 5. Iterative adaptations to BHF were completed to improve the fit of BHF to the setting and participants and have contributed to a sustained community PWMI that adheres to the underlying principles and core elements of other evidence-based PWMIs. Monitoring adaptations and related changes to outcomes can play a role in long-term sustainability and effectiveness.
NEW MATERIAL:The polypeptide of formula (X is L-norleucine residue or L- norvaline residue). USE:It has ACTH secretion accelerating activity and hypotensive activity comparable to corticotropin-releasing factor (CRF), and is useful as a diagnostic agent or a drug. The chemical structure of the polypeptide corresponds to that of CRF provided that the 21-methionine residue of CRF is substituted by norleucine residue or norvaline residue. It has high oxidation stability compared with CRF. PROCESS:The objective peptide can be prepared by bonding amino-protected alpha-amino acids and carboxyl-protected alpha-amino acids in the order of the amino acid sequence of the objective paptide by the conventional method for the synthesis of peptide (e.g. active ester process, mixed acid anhydride process, etc.). A solid-phase synthesis based on a synthetic resin (e.g. benzhydril synthetic resin) is most preferable as the bonding process. The resultant protected peptide resin is deprotected and purified to obtain the objective peptide.
A system and method for populating and processing prescription scripts to reduce human error and save time while filling prescriptions. A pharmacy e-pad and a local server are utilized by a pharmacy to receive prescription orders, process the prescription orders, and fill the prescription orders. The pharmacy e-pad utilizes a touchscreen, a processing unit, and in some embodiments a digital scanner. The touchscreen allows a pharmacist or technician to directly input information for filling a prescription, while the processing unit processes inputs and outputs through the pharmacy e-pad. Meanwhile, the digital scanner can be used to retrieve information from scannable codes. The local server provides a means for storing data, facilitating communication between the pharmacy e-pad and other pharmacy devices, and facilitating communication with other pharmacy or third-party servers.
It has been demonstrated that several neurologic and psychiatry disorders are associated with dysfunctional cortical inhibitory mechanisms and alterations in neurotrophins (biological markers involved in neuronal survival and plasticity) and that rTMS therapeutic effects are associated with changes in cortical excitability. CI produced by rTMS can be demonstrated through SICI, CSP and LICI. However it remains unclear which rTMS parameters induce the best CI. Exploring different rTMS stimulus conditions versus sham condition effects in CI of human motor cortex can be the way to identify the best rTMS therapeutic parameters. Also, evaluating the molecular effects produced by rTMS treatment on serum blood levels can help identify the mechanisms through which rTMS exerts its therapeutic effects and ultimately clarify mechanisms through which treatment effects are mediated.

This experiment intends to demonstrate the best rTMS parameters to acquire higher CI. If our hypotheses are correct, these parameters will help to obtain higher therapeutic effects, and consequently, improvement of rTMS treatments.
International Care Ministries (ICM) is a non-governmental organisation with a mission to reduce the burden of extreme poverty. ICM focused its work in the Philippines for more than 30 years and recently expanded to Uganda and Guatemala. The core poverty alleviation program at ICM is called Transform. Transform focuses on improving values, health and livelihood through a 15-week program (1 lesson per week). ICM has conducted three randomized controlled trials (RCT) in the Philippines. This RCT was designed in response to the expansion of ICM's work in Uganda. Realising the poverty issue that was exacerbated by the COVID-19 pandemic, ICM implemented its first Transform program in Uganda in 2020. As of May 2023, more than 210 communities and 5,921 participants received the Transform program in the regions of Kiboga and Kyankwanzi. Despite the fact that previous RCTs found a positive impact of Transform on certain poverty indicators in the Philippines, the effectiveness of Transform is not known in another context. The Philippines and Uganda are vastly different in terms of their economies, cultures and demographics. This study builds on the previous RCTs and aims to evaluate the Transform program on measures of economic outcomes, social capital, health, hope and spiritual well-being in a different context. Whether there will be similar results in Uganda will deepen perspectives in the universal elements of success that can be further adopted and scaled up in other countries. While a key challenge in poverty alleviation initiatives is the lack of high quality evidence to evaluate the effectiveness of programs, this study will use the gold standard of effectiveness research - RCT, to deepen understanding in the causal impact of the Transform program in another context.