anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A cardiac output probe assembly is disclosed wherein the assembly includes a chest tube which carries a cardiac output probe therein. The chest tube includes a main lumen for draining fluids from the thoracic cavity of the chest and a secondary lumen which carries leads attached to the probe. The probe is attached to the pulmonary artery or aorta vessel with detachable tines and/or sutures. The tines are uniquely configured to ensure that good contact between the probe and vessel is maintained. When cardiac output monitoring is complete, a pulling force is applied to the probe leads extending out through a proximal end of the tube. The pulling force detaches the tines and sutures, releasing the probe from connection with the vessel. Further withdrawal of the leads through the tube retracts the probe within the tube, where it is housed until the tube is removed from the thoracic cavity.
Repetitive transcranial magnet stimulation (rTMS) over the dorsomedial prefrontal cortices at 90% of the resting motor threshold of the foot flexors. The rTMS is given in 20 trains to the left and right dmPFC, respectively. Each train consists of 10 bursts at 5 Hz (theta-frequency), and each burst consists of 3 pulses at 50 Hz. The stimulation is intermittent with 2 seconds of stimulation, 8 seconds off. After a 15 minute break the whole protocol i applied again, resulting in 2400 pulses/day. Treatment is delivered daily at 10 week days.
BACKGROUND: Despite the end of the COVID-19 lockdown and reopening of schools, the long-term effects of quarantine on the weight status, eating habits, and lifestyle of children and adolescents remain unknown. This study aimed to determine the long-term effects of the lockdown on the weight status, eating habits, and lifestyle changes of children and adolescents in Iran.
METHOD: This descriptive cross-sectional study was conducted from April to May 2022. The target population comprised one hundred students aged between 10 and 16 years old. Our study obtained students' weight and height data from records maintained by school principals or physical education instructors before and after the quarantine period. The BMI z-score (zBMI) was calculated for each time point. The researchers also provided a questionnaire to collect the students' demographic and lifestyle status changes during school closures.
RESULTS: We found that the zBMI increased significantly from - 0.02 ± 1.64 to 0.36 ± 1.12, and the number of individuals with overweight and obesity increased by 3% during quarantine (P ≤ 0.05). These changes were more pronounced in males and students aged 14-16 years old. We also found that eating habits, sleeping time, sleeping patterns, screen time (time spent on social media per day), and physical activity had significant negative changes during quarantine, and a significant increase in zBMI was observed among students who experienced negative eating behaviors, altered sleeping patterns, and decreased physical activity during school closures.
CONCLUSION: As prolonged school closures due to the COVID-19 lockdown aggravated students' health and lifestyle status, our findings can aid in proper planning to establish an appropriate framework for the diet, physical activity, and sleeping quality of students during extended school closures.
Surgery offers the advantage of immediate and permanent stone removal, but carries a fairly high risk. In some patients, about 5% of cholecystectomized patients have residual symptoms or retained common duct stones. The spectrum to surgical risk varies as a function of age and the presence of disease other than cholelithiasis. Selected tabulation of results from the National Halothane Study (JAMA, 1968, 197:775-778) is shown below: the study included 27,600 cholecystectomies.  
  


  
  
Women in good health, or having only moderate systemic disease, under 49 years of age have the lowest rate (0.054%); men in all categories have a surgical mortality rate twice that of women; common duct exploration quadruples the rates in all categories; the rates rise with each decade of life and increase tenfold or more in all categories with severe or extreme systemic disease.  
Relatively young patients requiring treatment might be better treated by surgery than with chenodiol, because treatment with chenodiol, even if successful, is associated with a high rate of recurrence. The long-term consequences of repeated courses of chenodiol in terms of liver toxicity, neoplasia and elevated cholesterol levels are not known. Watchful waiting has the advantage that no therapy may ever be required. For patients with silent or minimally symptomatic stones, the rate of moderate to severe symptoms or gallstone complications is estimated to be between 2% and 6% per year, leading to a cumulative rate of 7% and 27% in five years. Presumably the rate is higher for patients already having symptoms.
112,498. Bart, H. Jan. 9, 1917. Fermenting.-Organic substances are treated with nitrous oxide gas for the purpose of destroying or rendering inactive micro-organisms, ferments, enzymes, &c., contained therein. The nitrous oxide may be employed alone at various specified temperatures at pressures exceeding 25 atmospheres, or may be employed at temperatures below 8‹ C., or in conjunction with other sterilizing or preserving media, at pressure as low at 5 atmospheres. Crystals of hydrated nitrous oxide (N2O, 6H2O) may be used in place of the gas and in corresponding quantities. The following materials are specified for use in conjunction with the nitrous oxide as preservatives &c., viz. alcohols, sugars, tartaric, malic, or citric acids, hydrogen peroxide, benzoic acid, boric acid, oxygen and carbon dioxide. The process is applied to the sterilization, preservation &c. of fresh or fermenting beer wort, musts, and fruit juices.
The purpose of this study is to determine if quetiapine decreases marijuana relapse in a controlled lab setting. For the purposes of this model, relapse is defined as a return to marijuana use after a period of abstinence. The study will utilize an inpatient/outpatient, counter-balanced design, with each participant maintained on placebo and quetiapine (200 mg/day) for 18 days. Participants will begin taking capsules as outpatients so that the dose can be incremented prior to the inpatient phase. While inpatient, participants will have the opportunity to self-administer placebo (0.0%) or active marijuana (6.2%) 6 times per day, depending on the study day. Our laboratory model, which has distinguished the effects of a range of medications on marijuana withdrawal and relapse, will provide important information on the effect of quetiapine as a potential short-term pharmacotherapy to facilitate abstinence in the initial stages of marijuana treatment.
Haloperidol should be initiated with the dose range from 5 mg/day to 15 mg/day from Day 1 to Day 5 (using injection) according to the clinical experience and prescribe information. After Day 7, the dose of haloperidol should be adjusted between 8 mg/day to 20 mg/day (change from injection to oral formulation between Day 6 to Day 7) at the discretion of the investigator.
In acetaminophen overdosage, dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma, and coagulation defects also may occur. Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting, diaphoresis, and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. 

In the treatment of acetaminophen overdosage, gastric decontamination with activated charcoal should be administered just prior to N-acetylcysteine (NAC) to decrease systemic absorption if acetaminophen ingestion is known or suspected to have occurred within a few hours of presentation. Serum acetaminophen levels should be obtained immediately if the patient presents 4 or more hours after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading. To obtain the best possible outcome, NAC should be administered as soon as possible where impending or evolving liver injury is suspected. Intravenous NAC may be administered when circumstances preclude oral administration.

Vigorous supportive therapy is required in severe intoxication. Procedures to limit the continuing absorption of the drug must be readily performed since the hepatic injury is dose-dependent and occurs early in the course of intoxication.
The present invention has the first technical scheme that 1 part by weight to 30 parts by weight of fructus momordicae, 1 part by weight to 10 parts by weight of sterculia and 1 part by weight to 5 parts by weight of Chinese white olive are pulverized and are orderly lixiviated for four times by 80 to 100 parts by weight of spirit at the temperature of 0 to 60 DEG C, each lixiviation lasts for 24 to 96 hours, lixiviating liquid is merged, and impurities are filtered off. 0.001 to 0.3 share of bovine calculus powder and 0.01 share to 5 shares of snake bile can be added to the obtained spirits to blend products with different alcoholicity. The present invention has the second technical scheme that 1 part by weight to 30 parts by weight of fructus momordicae, 1 part by weight to 10 parts by weight of sterculia and 1 part by weight to 5 parts by weight of Chinese white olive are pulverized and are orderly lixiviated for four times by 0.1 to 60%Vol spirit at an ordinary temperature, each lixiviation lasts for 10 to 30 hours, and lixiviating liquid is merged. 0.001 to 0.3 share of bovine calculus powder and 0.01 share to 5 shares of snake bile can be added. The present invention can resist respiratory tract infection of human bodies, and has obvious auxiliary therapeutic effect on tussis, asthma, toothache, bronchitis, etc. Serial products with different alcoholicity are suitable for different users.
Inj. Cisplatin 40 mg /m2 intravenous infusion delivered concurrently with radiotherapy on a weekly basis.
The trial is designed as an individually randomized, controlled, and non-blinded multicenter prevention trial with a baseline period and a primary endpoint of proportion of patients meeting one or more criteria for the Major Adverse Kidney Events within 30 days (MAKE30) composite of death, new renal replacement therapy, or persistent creatinine elevation ≥ 200% of baseline, all censored at the first of hospital discharge or 30 days. The trial will evaluate the efficacy of a machine learning algorithm for AKI prediction, in approximately 8,574 patients aged ≥ 18 years admitted to one of three participating study hospitals. Individual patient randomization will be performed at the time of the alert with a 1:1 allocation ratio. Patients will be evaluated for inclusion in the trial upon admission, and will be automatically enrolled upon meeting inclusion criteria. Because data collection will be conducted through noninvasive procedures that are routinely employed in clinical practice, it will require a waiver of informed consent. Trial efficacy will be assessed at regularly scheduled study visits, and safety will be monitored on an ongoing basis for all patients. Safety will be assessed through the collection of adverse events, laboratory tests, vital signs, and physical examinations throughout the study. An independent Data Monitoring Committee (DMC) will be formed to assist in the periodic monitoring of safety, data quality, and integrity of study conduct. In addition, the DMC will review the interim efficacy analysis performed to determine whether the primary endpoint has been met. Total trial duration is expected to be approximately 12 months.
OBJECTIVE: To investigate the life, sleep quality and anxiety of rosacea patients in Yunnan and the improvement of these aspects after treatment.
METHODS: A total of 141 patients with rosacea and 123 healthy controls were included in our study. The quality of life, sleep quality and anxiety of patients with rosacea and healthy controls were investigated by the Rosacea Severity Scores (RSSs), the Medical Outcomes Study 36-item short-form health survey (SF-36), the Pittsburgh Sleep Quality Index (PSQI) and Self-rating Anxiety Scale (SAS). The quality of life, sleep quality and anxiety of patients with rosacea were assessed again after treatment.
RESULTS: Compared with healthy controls, patients with rosacea had significantly lower physical component scores (PCS) and mental component scores (MCS) but higher PSQI and SAS scores. After treatment, rosacea patients showed significantly higher MCS but lower PSQI and SAS scores. Correlation analysis showed a significant correlation between PCS, MCS, PSQI, SAS and RSSs.
CONCLUSIONS: Patients with rosacea have a lower quality of life and sleep quality and tend to be more anxious than healthy controls. In addition, the mental quality of life, sleep quality and anxiety of rosacea patients can be significantly improved after treatment. Therefore, it is important to pay attention to the psychological status of rosacea patients. Psychological counseling and intervention are necessary to better prevent and treat rosacea.
Daily 240 mg Magnesium Nycomed Pharma. Intervention day 0 - day 28.
Chimeric antigen receptor (CAR) T cells enable T cells to recognize and kill tumor cells that express specific antigens through genetic engineering. CD19 is expressed on the membrane surface of pre-B cells and mature B cells, but not on the surface of T cells and normal granulocytes. It is an ideal therapeutic target for B cell-derived tumors. A large number of previous studies have confirmed that CD19 CAR-T cells are a safe and effective method for the treatment of ALL. In 2019, Locke FL\[1\] et al. reported a clinical study of CD19 CAR-T for r/r DLBL. 119 patients were enrolled. The objective response rate was 83%, the CR rate was 58%, and the median progression-free survival was 5.9. Months. Greatly improved the patient's prognosis.

Preclinical and clinical studies of CD19 CAR-T in r/r B-NHL have been extensively carried out. At the beginning of 2020, MorphoSys submitted its company-targeted CD19 monoclonal antibody to the FDA for r/r DLBL treatment and obtained FDA priority approval. It further confirms the safety and effectiveness of CD19 as a therapeutic target in r/r B-NHL. However, these CAR-T cells are constructed from patients' autologous T cells, and the production and preparation time is long; on the other hand, most patients have received multiple chemotherapy before CAR-T treatment, and the quantity and quality of T cells often cannot meet the needs of clinical treatment. It is also an important factor leading to the failure of CAR-T cell therapy, which limits the large-scale clinical application of CAR-T.

T cells sourced from healthy people are not only sufficient in quantity and quality guaranteed, but also available at any time. In December 2020, lancet\[2\] reported a clinical study of 19 patients receiving allogeneic CAR-T cell therapy for B-ALL. 14 patients were evaluated as CR/CRi (67%) 28 days after treatment, with a median sustained remission Time 4.1 months. Allogeneic CAR-T cells are safe and effective for the treatment of B-cell malignant diseases, and their clinical application range is expected to further improve the remission rate and survival rate of patients with R/R B-cell non-Hodgkin's lymphoma.
Abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. Misuse is the intentional use, for therapeutic purposes, of a drug by an individual in a way other than prescribed by a health care provider or for whom it was not prescribed. 

Gabapentin does not exhibit affinity for benzodiazepine, opioid (mu, delta or kappa), or cannabinoid 1 receptor sites. Gabapentin misuse and abuse have been reported in the postmarketing setting and published literature. Most of the individuals described in these reports had a history of polysubstance abuse. Some of these individuals were taking higher than recommended doses of gabapentin for unapproved uses. When prescribing gabapentin, carefully evaluate patients for a history of drug abuse and observe them for signs and symptoms of gabapentin misuse or abuse (e.g., self-dose escalation and drug-seeking behavior). The abuse potential of gabapentin has not been evaluated in human studies.
OBJECTIVES: To assess the impact of educational intervention by nurses guided by Orem's theory to reinforce the self-care abilities of patients experiencing myocardial infarction.
METHODS: The prospective, quasi-experimental case-control study was conducted from September 2020 to April 2021 at Dr. Ruth K.M. Pfau Civil Hospital, Karachi, and comprised myocardial infarction and heart failure patients with comorbidities diabetes mellitus and hypertension. The patients were randomised into experiment group A and control group B. Group A received educational intervention one day before and one day after discharge in line with the American Heart Association guidelines. Two 30-45-minute sessions of seven modules were conducted. Group B received routine information from ward staff. Assessment was done at baseline and first month and second month post-intervention using the Heart Failure Self-Care Index version 6.2. Data was analysed using SPSS 21.
RESULTS: Of the 80 patients, 40(50%) were in group A; 27(76.5%) males and 13(32.5%) females. The remaining 40(50%) patients were in group B; 20(50%) males and 20(50%) females. The overall age of the sample ranged 36-65 years and 48(60%) had a previous history of heart failure. The mean score of maintenance, management, confidence and overall self-care were significantly higher in group A compared to group B (p<0.05).
CONCLUSION: Nursing self-care educational intervention based on Orem's theory was found to be highly effective among patients of myocardial infarction and heart failure with respect to their self-efficacy ability.
The invention provides application of licochalcone A and a composition of glabridin and licochalcone A in preparing a medicine for treating colorectal cancer. Belongs to the technical field of anti-tumor biological medicines. The CCK-8 method is used for verifying the inhibitory activity of LCA and CMC on human colon cancer cells, and the survival rate is obviously reduced. The influence of LCA and CMC high and medium dose groups on the apoptosis of human colon cancer cells is detected by adopting a flow cytometry technology, and the apoptosis rate is increased. The influence of LCA and CMC on the migration of human colon cancer cells is researched through a cell scratch experiment, and the cell migration capability can be obviously inhibited. Through Transwell experiments, the influence of LCA and CMC on the invasion capacity of human colon cancer cells is researched, and the number of the invaded cells is obviously reduced. LCA and CMC can inhibit the proliferation of human colon cancer cells in vitro and induce the apoptosis of tumor cells, and the action mechanism of the LCA and the CMC is probably related to the inhibition of the signal pathway of PI 3K/AKT/mTOR.
The invention relates to a preparation method of wheat tonic wine. The tonic wine is prepared from wheat wine as base wine by using angelica, ginseng, Chinese wolfberry and red date as auxiliary materials. The brewage process strictly complies with the traditional ancient brewage method; and the wine is sealed and stored in an underground natural solution cavity for several years, appears natural amber, tastes thick and sweet, and has thick and pure vinosity. When being boiled with fresh eggs and drunk by a woman in the confinement in childbirth, the wine can quickly supplement nutrients for the puerpera, regulate the puerpera, promote breast milk secretion and quickly provide a healthy milk source for infants, and thus, is a necessary health-care wine for breast feeding. The wheat tonic wine can revitalize the puerpera, and help the woman to restore the figure and maintain youth. When being drunk for a long time, the wine has the effects of nourishing yin, tonifying the kidney, strengthening the spleen, warming the liver, promoting salivation, moistening the stomach, relaxing the bowels, strengthening the body, resisting aging, beautifying the face, promoting blood flow to regulate menstruation and the like. The prepared wine product has unique characteristics, and thus, has excellent market prospects.
<P>PROBLEM TO BE SOLVED: To provide a protein including a Neisserial amino acid sequence.  <P>SOLUTION: The protein includes the Neisserial amino acid sequence. The protein includes an amino acid sequence selected from the group consisting of specific sequences. A nucleic acid molecule encodes the protein including the amino acid sequence selected from the group consisting of the specific sequences. The protein includes sequences homologous (i.e. having sequence identity) to the Neisserial amino acid sequence. The use of a composition including the Neisserial amino acid sequence in the manufacture of a medicament for treating or preventing infection due to Neisserial bacteria is provided.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Group A received access to the full "Time for Living \& Caring" (TLC) intervention for 8 weeks (calendar + coaching + resources), followed by an 8-week maintenance period where they could continue to use the TLC intervention. The TLC intervention turned off after 16 weeks of exposure for all participants.
It is recognized that primary infection with Pneumocystis, an opportunistic and transmissible fungus, occurs early in childhood. Early investigations of primary infection considering the detection of P. jirovecii in respiratory specimens suggests that primary infection in infants without immunodeficiency could be either asymptomatic or symptomatic. The infection may be identified as an apparently benign respiratory infection evolving on its own, but may also be contemporaneous with another viral or bacterial respiratory infection. In addition, there are little data available on the genotypic characteristics of P. jirovecii in infants developing primary infection.

In this context, the project will focus on the detection of P. jirovecii in hospitalized infants, presented with symptoms, and without overt immunodeficiency. The prospective collection of biological, clinical and epidemiological data in these infants will make it possible to identify risk factors for the acquisition of the fungus and to address its role in symptoms and clinical presentation. A second focus will be on the identification and comparison of genotypes in infants developing primary infection and in immunocompromised adults developing PPC or colonized by the fungus. These two approaches are the necessary steps to address the putative role of these patient populations (infants and adults) in the human reservoir of the fungus. A third focus will be the detection and genotypic identification of P. jirovecii in infants and the exhaled air of infants in their environment. The potential role of infants as potential infectious sources may be determined.
The study is approved by the Regional Committee for Medical and Health Research Ethics. Participation is voluntary, and informed consent will be requested. Outpatients will be recruited by doctors at the Rheumatology Department at Haukeland University Hospital (HUH). Patients recruited will be included consecutively. The recruitment period will last up to 12 months. Anthropometrical measurements, analysis of body composition, blood tests, clinical parameters, and dietary data will be collected at baseline, and after 12, 24, 36 and 52 weeks.