anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a means which can be effectively and beneficially applied in a wide range of various situations requiring stimulation, regulation or induction of immunological reaction.  <P>SOLUTION: The present invention relates to a pharmaceutical composition comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention, the above problem was solved by the fact that introduction of the pharmaceutical composition into vertebrates achieved regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical composition is useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit (e.g. sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity).  <P>COPYRIGHT: (C)2010,JPO&INPIT
TENS with a frequency of 2-125 Hz for 30 minutes. FITT guidelines for flexibility; frequency: 5 times per week, intensity: stop before it becomes painful, time: 10-15 minutes,hold for 15 secs and type: major muscle groups( latissmus dorsi, trapezius, gluteus maximus, gluteus medius, gatrocnemius, soleus, hamstringsand paraspinals( errector spinae and multifidus through static stretching technique.
The floss is comprised of a texturized yarn that has been coated and impregnated with a water-soluble polymer and the water-soluble polymer coating cured and set while the yarn is stretched and is under tension. The yarn while stretched and tensioned is at a reduced width, which allows for easier insertion of the yarn floss between teeth. The yarn floss is wound onto a spool in the decreased width condition. For use, a length of floss is removed from the spool and placed between teeth. The saliva in the mouth dissolves the cured and set water-soluble polymer with the floss expanding to fill the space between the teeth. The floss is optionally coated with flavors, medicants and other substances. These can be synthetic or naturally occurring substances such as herbal substances.
BACKGROUND: Approximately 15% of patients who undergo total shoulder arthroplasty (TSA) have diabetes mellitus, and this group is particularly at risk for perioperative complications. The objective of this study was to quantify the effects of insulin dependence on the risk of 30-day perioperative adverse events after TSA in patients with diabetes mellitus using a large national database.
MATERIALS AND METHODS: We retrospectively identified patients with diabetes mellitus who underwent TSA in the National Surgical Quality Improvement Program (NSQIP) database from 2011 to 2020. Patients were grouped as having insulin-dependent or non-insulin-dependent diabetes mellitus. The primary outcome was 30-day complication, and secondary outcome variables included 30-day readmission, reoperation, and death. Multivariable logistic regression analyses adjusted for baseline differences were performed. The cohort included 5888 patients with diabetes mellitus who underwent TSA, with 1705 patients in the insulin-dependent group and 4183 patients in the non-insulin-dependent group.
RESULTS: The 30-day postoperative complication rate was higher in patients with insulin-dependent diabetes mellitus (8.7%) than in patients with non-insulin-dependent diabetes mellitus (5.6%). The 30-day hospital readmission rate was higher in patients with insulin-dependent diabetes mellitus (4.8%) than in patients with non-insulin-dependent diabetes mellitus (3.3%). These significant differences in complication and readmission rates persisted in the multivariable logistic regression analyses after adjusting for baseline differences between the two groups. Reoperation and death were not associated with insulin dependence.
CONCLUSION: Patients with insulin-dependent diabetes mellitus have higher odds of episode-of-care complication and readmission compared with patients with non-insulin-dependent diabetes mellitus, even after adjusting for between-group baseline differences. [Orthopedics. 2024;47(5):295-300.].
BACKGROUND/AIMS: Metabolic dysfunction-associated steatohepatitis (MASH) is an unmet clinical challenge due to the rapid increased occurrence but lacking approved drugs. Autophagy-related protein 16-like 1 (ATG16L1) plays an important role in the process of autophagy, which is indispensable for proper biogenesis of the autophagosome, but its role in modulating macrophage-related inflammation and metabolism during MASH has not been documented. Here, we aimed to elucidate the role of ATG16L1 in the progression of MASH.
METHODS: Expression analysis was performed with liver samples from human and mice. MASH models were induced in myeloid-specific Atg16l1-deficient and myeloid-specific Atg16l1-overexpressed mice by high-fat and high-cholesterol diet or methionine- and choline-deficient diet to explore the function and mechanism of macrophage ATG16L1 in MASH.
RESULTS: Macrophage-specific Atg16l1 knockout exacerbated MASH and inhibited energy expenditure, whereas macrophage-specific Atg16l1 transgenic overexpression attenuated MASH and promotes energy expenditure. Mechanistically, Atg16l1 knockout inhibited macrophage lipophagy, thereby suppressing macrophage β-oxidation and decreasing the production of 4-hydroxynonenal, which further inhibited stimulator of interferon genes(STING) carbonylation. STING palmitoylation was enhanced, STING trafficking from the endoplasmic reticulum to the Golgi was promoted, and downstream STING signaling was activated, promoting proinflammatory and profibrotic cytokines secretion, resulting in hepatic steatosis and hepatic stellate cells activation. Moreover, Atg16l1-deficiency enhanced macrophage phagosome ability but inhibited lysosome formation, engulfing mtDNA released by pyroptotic hepatocytes. Increased mtDNA promoted cGAS/STING signaling activation. Moreover, pharmacological promotion of ATG16L1 substantially blocked MASH progression.
CONCLUSION: ATG16L1 suppresses MASH progression by maintaining macrophage lipophagy, restraining liver inflammation, and may be a promising therapeutic target for MASH management.
Naproxen \& Omeprazole Subjects randomized to this arm will be asked to discontinue their current pain medications and take one 500mg naproxen capsule and one 40mg omeprazole capsule twice a day for the length of the study. This arm is double-blind, as neither participants nor study staff will know what medication the participants is receiving (blind to active versus placebo treatment).
The invention discloses single-wall carbon nano tube temperature-sensitive gel and a preparation method and application of the gel. The single-wall carbon nano tube temperature-sensitive gel (SWNT-GEL) is synthesized through copolymerization reaction of a combination product of  gelatin and oxidization single-walled carbon nanotubes (SWNT)-trimethoxy silane (APTS) and pNIPAM-NH2. The single-wall carbon nano tube temperature-sensitive gel is used for preparing an injection medicine delivery system and is used for preparing a light and heat conduction medium. The invention further provides a medicine for treating the cancer. The medicine comprises a medicine carrier prepared by the single-wall carbon nano tube temperature-sensitive gel and a cancer treatment medicine on the medicine carrier. The gel shows the good application prospect of temperature-sensitive hydrogel with the SWNT as the basis as the injection medicine delivery system and an over-high heat treatment medium, and particularly shows the effect of the temperature-sensitive hydrogel in gastric cancer treatment.
Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly effective specific therapies have recently become available for the 2 most frequent forms of cardiac amyloidosis: immunoglobulin light chain amyloidosis and transthyretin (ATTR) amyloidosis. Nevertheless, initiation of specific therapies requires recognition of cardiac amyloidosis and appropriate characterization of the amyloid type. Although noninvasive diagnosis is possible for ATTR cardiac amyloidosis, histological demonstration and typing of amyloid deposits is still required for a substantial number of patients with ATTR and in all patients with light chain amyloidosis and other rarer forms of cardiac amyloidosis. Amyloid histological typing can be performed using different techniques: mass spectrometry, immunohistochemistry, and immunoelectron microscopy. This review describes which patients require histological confirmation of cardiac amyloidosis along with when and how to type amyloid deposits in histologic specimens. Furthermore, it covers the characteristics and limitations of the different typing methods that are available in clinical practice.
QTc Prolongation

The effect of a single 25 or 50 mg dose of tetrabenazine tablets on the QT interval was studied in a randomized, double-blind, placebo-controlled crossover study in healthy male and female subjects with moxifloxacin as a positive control. At 50 mg, tetrabenazine caused an approximately 8 msec mean increase in QTc (90% CI: 5.0, 10.4 msec). Additional data suggest that inhibition of CYP2D6 in healthy subjects given a single 50 mg dose of tetrabenazine does not further increase the effect on the QTc interval. Effects at higher exposures to either tetrabenazine tablets or its metabolites have not been evaluated [see Warnings and Precautions (5.8), Drug Interactions (7.5)].

Melanin Binding

Tetrabenazine or its metabolites bind to melanin-containing tissues (i.e., eye, skin, fur) in pigmented rats. After a single oral dose of radiolabeled tetrabenazine, radioactivity was still detected in eye and fur at 21 days post dosing [see Warnings and Precautions (5.11)].
In the last two decades or so, a spectrum of benign, premalignant and malignant cervical glandular lesions exhibiting gastric differentiation has been described, with gastric-type adenocarcinoma representing the most common human papillomavirus (HPV)-independent cervical adenocarcinoma. More recently, limited literature has reported a variety of gastric-type glandular lesions at other sites within the female genital tract and, as in the cervix (the most common site for these lesions), a spectrum of benign, premalignant and malignant lesions has been proposed. We provide an update and review of the emerging spectrum of gastric-type glandular lesions at female genital tract sites other than the cervix. In the endometrium, putative gastric-type glandular lesions include mucinous metaplasia of gastric-type, atypical mucinous proliferation of gastric-type and gastric-type adenocarcinoma. Similarly in the vagina, gastric-type adenosis, atypical adenosis and adenocarcinoma have been described. There have also been occasional reports of gastric-type lesions involving the ovary and fallopian tube. We provide guidance on how to recognise gastric-type lesions morphologically and immunophenotypically and stress that sometimes these lesions occur at more than one site within the female genital tract (synchronous/multifocal gastric-type lesions of the female genital tract), sometimes in association with Peutz-Jeghers syndrome.
The invention provides a drug cessation medicine. The invention is characterized in that the medicine consists of the raw material medicines by weight proportion as follows: 15 to 30 portions of radix astragali, 15 to 25 portions of angelica, 10 to 20 portions of largehead atractylodesrhizome, 15 to 20 portions of epimedium, 15 to 20 portions of dandelion, 5 to 10 portions of manchurian wildginger, 5 to 10 portions of ephedra herb, 10 to 20 portions of dried ginger, and 10 to 25 portions of liquoric root. The invention has the functions of clearing away heat and toxic material, calming liver and activating blood, eliminating dry, curing wind, eliminating bruise and toxicity, warming spleen and stomach, getting through the blood vessels, nourishing the blood and reinforcing qi, promoting sperm production, calming five internal organs, strengthening physique, and promoting consciousness. The invention has a relatively good treatment effect for symptoms such as yin-yang floating, waist and knee cold pain, heat-syndrome in the upper part but cold in the lower, heart and rib pain, cholera, headache and lung qi weak, lacking of ordering the nervus centralis. As a traditional Chinese medical preparation, the invention comprises no materials which can cause craving, so that repeated use is unable to produce new dependence. Besides, the invention has the advantages of nontoxic and no side effect, and is safe and reliable. After application of the medicine, the drudgers can restrain the drug craving quickly, with quick cessation, low rebound rate and quick physical strength recovery.
Individuals with severe-to-profound hearing impairment, who no longer benefit from hearing aids, are candidates for cochlear implantation. In many cases these devices provide access to sound and are successful in restoring speech understanding; however, there are instances where individuals might need additional assistance in the form of auditory training (AT). This study will involve comparison of two groups of individuals. Participants will be randomly assigned to the standard of care group OR the remote care group. Individuals who meet eligibility criteria will be contacted to assess their willingness to participate in additional auditory training (AT) sessions. These sessions will be conducted either face-to-face or via the Ontario Telehealth network as per random assignment. AT sessions will occur over the first 3 months following activation of the cochlear implant. Outcomes will be assessed using performance measures and questionnaires.
PURPOSE:To obtain an antimicrobial and deodorizing material by blending Japanese horseradish as an active ingredient with other ingredients. CONSTITUTION:An antimicrobial and deodorizing material obtained by dissolving (including floating) a small amount of Japanese horseradish which is a plant belonging to the family Cruciferae in (a) a liquid, such as water or an alcohol, (b) mixing a small amount thereof with fats and oils, etc., to provide an ointment form or (c) mixing the small amount thereof with toothpaste, tooth powder or chewing gum. In the case of (a), an object, such as cloth, leather or processed product thereof, is sprayed with the resultant liquid or dipped therein to provide clothes, shoes, boots or hats, etc., processed from the liquid antimicrobial and deodorizing material capable of homogeneously applying the Japanese horseradich to the afore-mentioned object or material treated with the above- mentioned antimicrobial and deodorizing material. In the case of (b), a pasty antimicrobial and deodorizing material facilitating uniform application to objects including human bodies is obtained. Furthermore, in the case of (c), the toothpaste, tooth powder or chewing gum having antimicrobial and deodorizing effects is provided. In addition, powdery Japanese horseradish is used for the tooth powder.
Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.
Current first-line therapies for seizure management recommend benzodiazepines, which target gamma-aminobutyric acid type A channels to stop the seizure activity. However, seizures may be refractory to traditional first-line therapies, transitioning into status epilepticus and becoming resistant to gamma-aminobutyric acid type A augmenting drugs. Although there are other antiseizure medications available for clinicians to use in the intensive care unit, these options can be less readily available outside of the intensive care unit and entirely absent in the prehospital setting. Instead, patients frequently receive multiple doses of first-line agents with increased risk of hemodynamic or airway collapse. Ketamine is readily available in the prehospital setting and emergency department, has well-established antiseizure effects with a favorable safety profile, and is a drug often used for several other indications. This article aimed to explore the utilization of ketamine for seizure management in the prehospital setting, reviewing seizure pathophysiology, established treatment mechanisms of action and pharmacokinetics, and potential benefits of early ketamine use in status epilepticus.
The invention relates to a method of treating dermatological conditions or symptoms associated therewith in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the affected area of skin on the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier. The invention relates to a method of treating dermatological conditions or symptoms associated therewith in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the affected area of skin on the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier. A blood pressure cuff is defined by a first sheet and a second sheet. The first sheet has a first interior-inflatable surface attached to a second interior-inflatable surface of the second sheet to form an interior-inflatable portion between the first sheet and second sheet. The interior-inflatable portion is in communication with an opening to fluidly interconnect the interior inflatable portion with an exterior of the cuff. A textured surface is included on the second interior-inflatable surface.
Nitrofurantoin capsules, USP (monohydrate/macrocrystals) are indicated only for the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus.

Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of nitrofurantoin capsules (monohydrate/macrocrystals)and other antibacterial drugs, nitrofurantoin capsules (monohydrate/macrocrystals)should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections. Consequently, many patients who are treated with nitrofurantoin capsules (monohydrate/macrocrystals) are predisposed to persistence or reappearance of bacteriuria. (See CLINICAL STUDIES.) Urine specimens for culture and susceptibility testing should be obtained before and after completion of therapy. If persistence or reappearance of bacteriuria occurs after treatment with nitrofurantoin capsules (monohydrate/macrocrystals), other therapeutic agents with broader tissue distribution should be selected. In considering the use of nitrofurantoin capsules (monohydrate/macrocrystals), lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized.
We present a rare pediatric case of cardiac inflammatory pseudotumor (IPT) with a unique presentation of fever of unknown origin with markedly elevated inflammatory markers. A right atrial mass was discovered incidentally by echocardiography. The cardiac magnetic resonance (CMR) signal characteristics and mass location were not consistent with any of the common benign cardiac tumors of childhood. The presence of high signal intensity on T2 imaging and late gadolinium enhancement, in conjunction with intense metabolic activity at the mass site on positron emission tomography (PET), raised the possibility of an inflammatory or malignant mass. The diagnosis of IPT was confirmed by biopsy. Our case highlights the utility of PET imaging to confirm the inflammatory nature and extent of an IPT.
The invention relates to penicillium chrysogenum producing immunoregulatory active extracellular polysaccharide, a preparation method and application thereof. The Penicillium chrysogenum (Penicillium chrysogenum) MS-02 was deposited at the China general microbiological culture Collection center, address: the preservation number of the Beijing city Chaoyang area North Chen Xili No. 1 and 3 is CGMCC No.40652. The invention also provides a method for preparing the extracellular polysaccharide PPS2-A by using the penicillium chrysogenum MS-02 and application of the extracellular polysaccharide PPS 2-A. The penicillium chrysogenum MS-02 provided by the invention can stably and efficiently produce extracellular polysaccharide, and the yield can reach 812mg/L. The extracellular polysaccharide PPS2-A has good immunoregulatory activity, can obviously promote the proliferation of spleen lymphocytes of mice, promote the cell proliferation and phagocytic capacity of macrophages, obviously promote the release of NO, IL-1 beta, TNF-alpha and IL-6 cytokines of the macrophages, and shows that the extracellular polysaccharide PPS2-A has good immunoregulatory activity and has great development and application prospects.
Women will receive an initial dose of oral nifedipine 10mg. If blood pressure exceeds 155mmHg systolic OR 105 mmHg diastolic after 1h, an additional 10mg dose can be provided each hour for two additional doses (30 mg total).