anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
6-benzylaminopurine (6-BA), a multifunctional plant growth regulator, which is frequently used worldwide to improve qualities of various crops, is an important ingredient in production of "toxic bean sprouts." Although there is no direct evidence of adverse effects, its hazardous effects, as well as joint toxicity with other chemicals, have received particular attention and aroused furious debate between proponents and environmental regulators. By use of human umbilical vein endothelial cells (HUVECs), adverse effects of 6-BA to human-derived cells were first demonstrated in this study. A total of 25-50 mg 6-BA/L inhibited proliferation, migration, and formation of tubular-like structures by 50% in vitro. Results of Western blot analyses revealed that exposure to 6-BA differentially modulated the MAPK signal transduction pathway in HUVECs. Specifically, 6-BA decreased phosphorylation of MEK and ERK, but increased phosphorylation of JNK and P38. In addition, 6-BA exacerbated atorvastatin-induced cerebral hemorrhage via increasing hemorrhagic occurrence by 60% and areas by 4 times in zebrafish larvae. In summary, 6-BA elicited toxicity to the endothelial system of HUVECs and zebrafish. This was due, at least in part, to discoordination of MAPK signaling pathway, which should pose potential risks to the cerebral vascular system.
The application takes radix tetrastigme extract as a research object, particularly researches on protocatechuic acid methyl ester and isovitexin, searches for a component combination with synergistic anti-inflammatory action, verifies that the isovitexin and the protocatechuic acid methyl ester have synergistic anti-inflammatory action through a designed experiment, and has the action mechanism related to inhibiting excessive secretion of inflammatory factors such as TNF-alpha, IL-6, IL-10 and the like, inhibiting phosphorylation of inflammatory pathway proteins such as ERK, JNK, conclusion 53p65 and the like and promoting the expression of antioxidant related Nrf2 proteins. Experiments prove that the isovitexin and the protocatechuic acid methyl ester have synergistic anti-inflammatory effect, and the effect occurs in cytoplasm. Experiments find that 5 mu mol.L  ‑1  ‑250μmol·L  ‑1  The protocatechuic acid methyl ester in the concentration range has anti-inflammatory activity. Which is a kind ofIn 5. Mu. Mol.L  ‑1  Isovitexin +250 mu mol.L  ‑1  The CI value of the protocatechuic acid methyl ester is 0.13377, and the synergistic effect is excellent.
Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 diabetes and obesity, identified >20 associated loci. However, most loci were identified in populations of European ancestry, and many of the target genes underlying the associations remain unknown. We conducted a cross-ancestry adiponectin GWAS meta-analysis in ≤46,434 individuals from the Metabolic Syndrome in Men (METSIM) cohort and the ADIPOGen and AGEN consortiums. We combined study-specific association summary statistics using a fixed-effects, inverse variance-weighted approach. We identified 22 loci associated with adiponectin (p < 5×10-8), including 15 known and seven previously unreported loci. Among individuals of European ancestry, Genome-wide Complex Traits Analysis joint conditional analysis (GCTA-COJO) identified 14 additional distinct signals at the ADIPOQ, CDH13, HCAR1, and ZNF664 loci. Leveraging the cross-ancestry data, FINEMAP + SuSiE identified 45 causal variants (PP > 0.9), which also exhibited potential pleiotropy for cardiometabolic traits. To prioritize target genes at associated loci, we propose a combinatorial likelihood scoring formalism (Gene Priority Score [GPScore]) based on measures derived from 11 gene prioritization strategies and the physical distance to the transcription start site. With GPScore, we prioritize the 30 most probable target genes underlying the adiponectin-associated variants in the cross-ancestry analysis, including well-known causal genes (e.g., ADIPOQ, CDH13) and additional genes (e.g., CSF1, RGS17). Functional association networks revealed complex interactions of prioritized genes, their functionally connected genes, and their underlying pathways centered around insulin and adiponectin signaling, indicating an essential role in regulating energy balance in the body, inflammation, coagulation, fibrinolysis, insulin resistance, and diabetes. Overall, our analyses identify and characterize adiponectin association signals and inform experimental interrogation of target genes for adiponectin.
Counseled to consume a diet with a low or higher intake of carbohydrate sources that cause rapid or significant intakes in blood glucose. The average glycemic load of the diet should be less than 55 per 1000 calories or greater than 55 per 1000 calories.
INTRODUCTION: Three recent randomised controlled trials have demonstrated that pulmonary vein isolation as an initial rhythm control strategy with cryoablation reduces atrial arrhythmia recurrence in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drug (AAD) therapy. The aim of this study was to evaluate the cost-effectiveness of first-line cryoablation compared with first-line AADs for treating symptomatic PAF in an English National Health Service (NHS) setting.
METHODS: Individual patient-level data from 703 participants with PAF enrolled into Cryo-FIRST (Catheter Cryoablation Versus Antiarrhythmic Drug as First-Line Therapy of Paroxysmal Atrial Fibrillation), STOP AF First (Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation) and EARLY-AF (Early Aggressive Invasive Intervention for Atrial Fibrillation) were used to derive the parameters applied in the cost-effectiveness model (CEM). The CEM comprised a hybrid decision tree and Markov structure. The decision tree had a 1-year time horizon and was used to inform the initial health state allocation in the first cycle of the Markov model (40-year time horizon; 3-month cycle length). Health benefits were expressed in quality-adjusted life years (QALYs). Costs and benefits were discounted at 3.5% per year. Model outcomes were generated using probabilistic sensitivity analysis.
RESULTS: The results estimated that cryoablation would yield more QALYs (+0.17) and higher costs (+£641) per patient over a lifetime than AADs. This produced an incremental cost-effectiveness ratio of £3783 per QALY gained. Independent of initial treatment, individuals were expected to receive ~1.2 ablations over a lifetime. There was a 45% relative reduction in time spent in AF health states for those initially treated with cryoablation.
DISCUSSION: AF rhythm control with first-line cryoablation is cost effective compared with first-line AADs in an English NHS setting.
Preparation of 1,1,2,2 - tetrachloroethyl sulphenyl chloride by reacting trichloroethylene with sulphur dichloride at a temperature in the range of from 50 DEG  to 200 DEG  C. in the presence of at least one promoter compound, which may be present in an amount of from 20 parts per million to 5 weight per cent of the reaction mixture, selected from a trialkyl-phosphate, a dialkyl-phosphochloridate, a saturated aliphatic secondary or tertiary amine or a nuclear hetero cyclic amine.  Suitable trialkyl-phosphates and dialkyl-phosphochloridates may have alkyl or haloalkyl substituents each containing from 1 to 12 carbon atoms and preferably have C2- 4 alkyl substituents, e.g. triethyl- or tri-butyl-phosphate or diethyl-phosphochloridate.  Speci fied saturated amines are represented by the formula <F\1> wherein R1 is hydrogen or an alkyl group having from 1 to 12, preferably 1 to 6, carbon atoms and R2 and R3, which may be the same or different, are saturated alkyl groups of from 1 to 12, preferably 1 to 6, carbon atoms or, when R1 is hydrogen, poly(alkyleneamine) groups represented by the formula -(CH2CH2NH)m(CH2CH2)nH where m is an integer from 1 to 6 and n is 0 or 1. In the preferred dialkylamines the alkyl groups have a combined total of 2 to 12 carbon atoms, e.g. di-iso-propylamine, and in the preferred trialkylamines, the alkyl groups have a com bined total of from 3 to 18 carbon atoms, e.g. tri-ethylamine.  The preferred heterocyclic amines have a single nitrogen atom and from 4 to 8 carbon atoms, 4 or 5 of these being in the ring nucleus, and may be aromatic or saturated. The reaction may be carried out at or above atmospheric pressure optionally in the presence of an inert diluent.
The invention discloses rhodiola crenulata toner with whitening and moisturizing effects. The rhodiola crenulata toner is mainly prepared from black tea extract, rhodiola crenulata root extract, blueberry fruit extract and corresponding adjuvants. Rhodiola crenulata can nourish and moisturize skin and keep constant moisture and elasticity of the skin, has anti-oxidation and whitening functions and is called 'gold plant' in the Compendium of Materia Medica. Blueberry is honored as a 'skin cosmetic taken orally' and rich in anthocyanin which is a purely natural anti-aging nutrition supplement. Black tea can moisturize skin, promote blood circulation and activate cells, and also has antibacterial and refreshing functions and the like. The rhodiola crenulata toner, taking rhodiola crenulata as 'monarch', blueberry as 'minister' and black tea as 'assistant', can promote skin metabolism, enhance activity, keep moisture, effectively contract pores, smoothen rough skin, improve skin gloss and enable the skin to become young, fine and smooth.
Data from a plurality of sensors representing a patient's condition, including the measurement signals and also secondary parameters derived from the measurement signals, are displayed in a simple way by mapping them from the multidimensional measurement space to a two-dimensional visualisation space. This can be achieved using a mapping which preserves the topography of the data points, for instance by ensuring that the inter-point distances in the visualisation space match as closely as possible the corresponding inter-point distances in the measurement space. Such a mapping, for instance Sammon's mapping is achieved by a suitably trained artificial neural network. The parameters are normalised before the mapping process and the normalisation and mapping are such that mapped points from a patient whose condition is normal appear in the centre of the visualisation space, whereas points from a patient whose condition is abnormal appear at the edge of the visualisation space. The artificial neural network may be trained using data points from a single patient or from a group of patients, and data may be thinned out using a pre-clustering algorithm. <IMAGE>
The present invention relates to a Jiuweimingmuzhujing powder for improving eyesight, which is made from traditional Chinese medicine. The present invention contains powder which is made from nine peculiar traditional Chinese medicine recipes of papermulberry fruit, dodder, schisandra, barbary wolfberry fruit, etc. The present invention does not contain sugar or preservative. The present invention has good effects for essence and blood deficiency of the liver and the kidney, losing of nutrition of eyes without clear sight, liver dysfunction, blocking of sweat pore, blindfold of eyes of not distinguishing of color. Through clinical observation, the present invention has the obvious curative effect for center type serosity chorioretinopathy, optic neuropathy, senile cataract (initial stage), retinitis pigmentosa, presbyopia, etc. The present invention is the ideal medicine for supplementing the liver, tonifying the kidney, coursing the liver and removing depression in ophthalmology.
Both mouse and rat lifetime carcinogenicity studies were conducted. There was no significant difference in the incidence of tumors between the indapamide-treated animals and the control groups.

Pregnancy: Teratogenic Effects: Reproduction studies have been performed in rats, mice and rabbits at doses up to 6,250 times the therapeutic human dose and have revealed no evidence of impaired fertility or harm to the fetus due to indapamide. Postnatal development in rats and mice was unaffected by pretreatment of parent animals during gestation. There are, however, no adequate and well-controlled studies in pregnant women. Moreover, diuretics are known to cross the placental barrier and appear in cord blood. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. There may be hazards associated with this use such as fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in the adult.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because most drugs are excreted in human milk, if use of this drug is deemed essential, the patient should stop nursing.

Pediatric Use: Safety and effectiveness of indapamide in pediatric patients have not been established.

Geriatric Use: Clinical studies of indapamide did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.  
  


Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of indapamide in elderly females (see WARNINGS).
Psycho-education video + an attention training consisting of 10 sessions of ±12 minutes each (during an intervention period of two weeks) will be administered. The training task is a positively directed scrambled sentences task with online contingent feedback on how much attention was paid to positive vs. negative words (emotional attention), along with feedback on the speed with which the sentences were made.
A computer-based system designed to support socialization and access to resources; knowledge and prospective memory. The system is placed in the homes of those randomized to the condition for 12 months.
Participants received carfilzomib 20 mg/m² administered by intravenous bolus on Cycle 1 Days 1, 2, 8, 9, 15 and 16, then 27 mg/m² in all subsequent cycles, for up to 12 cycles. Participants also received 20 mg dexamethasone (DEX) administered before each dose of carfilzomib (i.e. 40 mg weekly).
FIELD: medicine; bioengineering. SUBSTANCE: method involves detecting natural antibodies, recognizing proteins extracted from goat liver. The proteins have molecular mass of approximately 14 kDa, show antitumor activity when administered to xenogenic species. Composition contains effective quantity of antibodies or hyperimmune sera induced by immunizing human beings or animals with the proteins extracted from goat liver and having molecular mass of 14 kDa. EFFECT: high quality of compositions having cytotoxic activity. 4 cl, 2 dwg 1 tbl
Participants will be administered with KP104 dose regimen 2 for 24 Weeks. After the last participant completes 6 weeks of treatment, all available data, including safety, PK, PD, and modeling results, will be reviewed by the IDRC to determine Dosing Regimen 3.
BACKGROUND: Progressive multiple sclerosis (MS) is a chronic immune-mediated disease with a poorly understood pathophysiology. This bibliometric analysis of the literature aims to gain an overview of the current state of research on progressive MS.
METHODS: The Scopus database was searched using the terms "progressive" and "multiple sclerosis" in the title. The search was done till the 7th of January 2023. We analyzed annual trends, countries, institutions, authors, journals, articles, and keywords based primarily on the citation count.
RESULTS: One thousand nine hundred ninety-one studies out of 1993 search results were included. The included studies had 65,788 citations with a mean of 33 citations per study. Most studies were published between the years 2016 and 2020 (n = 607) with a mean number of 20 citations. The United States of America had the highest number of publications (n = 547) and citations (n = 24,921). The top 3 authors were Thompson A.J., Miller D.H., and Filippi M., and Multiple Sclerosis Journal had the most publications (n = 227) and citations (n = 6849).
CONCLUSION: To our knowledge, this is the first bibliometric study to address the topic of progressive MS in particular and potentially emphasize the direction of progressive MS research.
The oral cavity houses one of the most diverse microbiota in the human body. There are nearly 800 unique oral bacterial species identified with more species expected to be added with further sampling and identification. As with microbiota of other sites in the body, a balanced oral microbiota is essential to maintaining the health of the human host. Streptococcus salivarius is a pioneer species that colonizes the human oral cavity from birth, and remains a predominant member of the commensal microbiota throughout life. The commensal microbiota provides protection against pathogenic species associated with conditions such as dental caries, periodontal disease, and oral malodor (halitosis). This randomized, double-blind, placebo-controlled study is conducted to investigate the effect of a Streptococcus salivarius DB-B5 strain on oral bacteria levels and halitosis. Doses of 2 billion and 10 billion colony forming units (CFU) per day are tested.
The present invention generally relates to microgel compositions and methods and, in some cases, to compositions and methods for drug release and/or scavenging. One aspect of the invention is generally directed to a composition comprising a microgel. 5 The composition may be capable of binding and/or releasing a drug or other material. The composition may be used, in some embodiments, to reduce the amount of a material in a solution In other embodiments, the composition may be used to release a material (ι e, a drug) In another aspect, the invention is directed to microgel aggregates. In some embodiments, the aggregates may form in response to a change in temperature. An 10 aggregate may be used, for example, to immobilize microgel particles, entrap cells, encapsulate a material, and the like
This study is a randomized controlled trial in which patients will be randomly assigned into one of four groups: those receiving onabotulinumtoxinA (Botox, Allergan, Irvine, California), abobotulinumtoxinA (Dysport, Ispen Biopharmacueticals Inc.Cambridge, MA), incobotulinumtoxinA (Xeomin, Raleigh, NC) or prabotulinumtoxinA (Jeuveau, Evolus, Newport Beach, California). Each patient will receive FDA approved dosages in which they are assigned in to treat rhytids within the glabella, as per FDA approved indications. All injections will be performed by a blinded single trained physician according to a preset injection plan per FDA approved administration guidelines. Prior to injection patients will be imaged with 3-dimensional photogrammetry. All pre-procedure images will be evaluated for absolute strain performing two types of facial animation: 1) relaxed, and 2) frowning. Subjects will return Day 3, 30, 90, and 180, post intervention for re-imaging with the same expressions. Strain will be calculated using the same metrics.
No LUM015 injection will be given to three (3) patients, in each indication, to measure baseline tissue fluorescence. Imaging with the LUM imaging device will be performed in vivo and ex vivo on surgical tissue.
Uneven rainfall and high temperature cause drought in tropical and subtropical regions which is a major challenge to cultivating summer mung bean. Potassium (K), a major essential nutrient of plants can alleviate water stress (WS) tolerance in plants. A field trial was executed under a rainout shelter with additional K fertilization including recommended K fertilizer (RKF) for relieving the harmful impact of drought in response to water use efficiency (WUE), growth, yield attributes, nutrient content, and yield of mung bean at the Regional Agricultural Research Station, BARI, Ishwardi, Pabna in two successive summer season of 2018 and 2019. Drought-tolerant genotype BMX-08010-2 (G1) and drought-susceptible cultivar BARI Mung-1 (G2) were grown by applying seven K fertilizer levels (KL) using a split-plot design with three replications, where mung bean genotypes were allotted in the main plots, and KL were assigned randomly in the sub-plots. A considerable variation was observed in the measured variables. Depending on the different applied KL and seed yield of mung bean, the water use efficiency (WUE) varied from 4.73 to 8.14 kg ha-1 mm-1. The treatment applying 125% more K with RKF (KL7) under WS gave the maximum WUE (8.14 kg ha-1 mm-1) obtaining a seed yield of 1093.60 kg ha-1. The treatment receiving only RKF under WS (KL2) provided the minimum WUE (4.73 kg ha-1 mm-1) attaining a seed yield of 825.17 kg ha-1. Results showed that various characteristics including nutrients (N, P, K, and S) content in stover and seed, total dry matter (TDM) in different growth stages, leaf area index (LAI), crop growth rate (CGR), root volume (RV), root density (RD), plant height, pod plant-1, pod length, seeds pod-1, seed weight, and seed yield in all pickings increased with increasing K levels, particularly noted with KL7. The highest grain yield (32.52%) was also obtained from KL7 compared to lower K with RKF. Overall, yield varied from 1410.37 kg ha-1 using 281 mm water (KL1; well-watered condition with RKF) to 825.17 kg ha-1 using 175 mm water (KL2). The results exhibited that the application of additional K improves the performance of all traits under WS conditions. Therefore, mung beans cultivating under WS requires additional K to diminish the negative effect of drought, and adequate use of K contributes to accomplishing sustainable productivity.
PURPOSE: A composition containing Loranthus yadoriki SIEB. extract is provided to suppress MAO enzyme activation in vitro and to enhance immunity. CONSTITUTION: A monoamine oxydase(MAO) inhibitor contains Loranthus yadoriki SIEB. extract. A pharmaceutical composition for preventing and treating MAO enzyme-related depression contains the extract with an effect of suppressing monoamine oxidase. The extract is a crude extract, polar solvent soluble extract, or non-polar solvent soluble extract. The crude extract is prepared using water, spirit, low alcohol of 1-4 carbon atoms, or a mixture solvent thereof.
PURPOSE: A cosmetic composition containing herb extract is provided to enhance and maintain skin moisturization with non-irritation and safety to the skin. CONSTITUTION: A cosmetic composition for skin moisturization contains fermentation extract of herb material which is fermented with yeast or lactobacillus. The herb materials are ulaca oleracea, Liriope platyphylla, Psoralea corylifolia, Rehmannia glutinosa, Papaver rhoeas, Nelumbo nucifera, Ponciruc trifoliate, Ligusticum officinale, Asparagus lucidus, or Cuscuta japonica. The herb extracts are contained in 0.0001-10 weight% based on total weight. The yeast is Saccharomyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., or Candida sp. The lactobacillus is Lactobacillus sp., Streptococcus sp., Leuconostoc sp., or Bifidobacteria sp. The cosmetic composition is used in the form of external use skin ointment, soft skin, nutrition cream, massage cream, essence, pack, emulsion, or oil gel.