anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients with attention-deficit/hyperactivity disorder (ADHD) suffer from inattention, hyperactivity, and impulsivity. Clinicians often assume that the specific difficulties associated with ADHD are bound to affect sexual behaviors, and favor risky sexual behaviors, thereby increasing the frequency of sexually transmitted diseases (STDs). This review provides an up-to-date synthesis of the literature concerning STDs in patients with ADHD. A systematic review of the literature was performed using the PubMed, PsychInfo, and Embase databases, with STDs as the main outcome measure. Patients with ADHD report more STDs than the general population. Results are limited by the small number of existing studies, as well as the heterogeneity of the outcome measures. Findings from this first systematic review of data on STDs in individuals with ADHD suggest that ADHD affects sexual health and sexual behaviors. Clinicians treating patients with ADHD should explore risky sexual behaviors in their patients and raise awareness about the risk of contracting STDs. Further studies are warranted to better evaluate the risk of contracting an STD in patients with ADHD.
Participants will receive escalating doses of loncastuximab tesirine (initial dose of 60 μg/kg and highest dose possibly tested of 150 µg/kg) in combination with R-CHOP (rituximab 375 mg/m\^2, cyclophosphamide 750 mg/m\^2, doxorubicin 50 mg/m\^2, vincristine 1.4 mg/m\^2, and prednisone 100 mg/day) according to a standard 3+3 dose escalation design. The dose escalation part will be completed once the maximum tolerated dose (MTD)/recommended dose for expansion (RDE) has been identified.
Subjects will receive oral ORH-2014 at a planned starting dose of 5 mg once daily (QD) in the fasted state. If escalation criteria are met, the administered dose will increase by 5 mg increments to a maximum of 50 mg QD. The starting daily dose is approximately half the typical IV dose (0.15 milligram per kilogram \[mg/kg\]) extrapolated to a 70-kg person.
Material and Method: Total of 54 American Society of Anesthesiologist Grade 1-2, Mallampati score 1 or 2, age between 18 to 65 patient planned to undergo nonopthalmic surgery will be included to study. Patients with glaucoma, diabetes mellitus, cardiovascular and pulmonary diseases, American Society of Anesthesiologist Grade III and IV, body mass index more than 35, difficult intubation, undergo obstetrical surgery and propofol, fentanyl, rocuronium contraindicated will be excluded from the study. Patients will be divided randomly into 2 groups as direct laryngoscopic and fiberoptic intubation group. Patients will be preoxygenated with %100 O2 for 3 minutes then anesthesia will be induced using propofol 2 mg / kg, fentanyl 1 mcg/kg, and rocuronium 0,5 mg / kg in both groups. After 3 minutes mask ventilation, patients will be intubated (women with No:7-7,5, men with No:8-8,5 intubation tube). Systolic blood pressure, diastolic blood pressure, mean arterial pressure, peripheral oxygen saturation,perfusion index will be recorded and intraocular pressure measured by ophthalmologist by tonopen device will be recorded pre-induction (basal), after induction, 1,2,3,5 minutes after intubation, respectively. Period between handling of laryngoscope or fiberoptic device after termination of mask ventilation and obtain end tidal CO2 will be accepted as application time and recorded. Study will be terminated after 5th minute values taken.
Bronchiectasis is characterized pathologically by permanent bronchial dilatation and airway inflammation, and clinically by productive cough, hemoptysis and periodic infectious exacerbations. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully understood. Current available therapeutic options have shown only a modest impact on disease outcomes in randomized clinical trials. The concept of "treatable traits" was proposed as biomarker-directed approach, based on the recognition of clinical phenotype and endotypes, help to personalized treatment options. Potential treatable traits of airways disease into four broad categories: pulmonary, extra-pulmonary, etiological, and behavior and lifestyle treatable traits. Airway microbiota, including bacteria, NTM and fungus, have important but different inflammatory process in bronchiectasis. Our study will provide a new concept that airway microbiota might involve in the airway and systemic inflammation, mucus hypersecretion, as well as the airway damage, remodeling, and frequent exacerbations in bronchiectasis, thus leading to the deterioration of disease severity.

Bronchiectasis remains a major cause of respiratory morbidity and treatment is generally only partly successful. Our study will give more clues about the mechanisms by which the immunomodulatory medications (macrolides) on the inflammatory pathway and the probably different response among patients with different isolated microbiota from airways. Thus, our results will not only shed light on the airway microbiota inflammatory mechanisms responsible for disease severity, but also provide a new therapeutic direction.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel tetrasubstituted derivatives of imidazole of the formula (I)   where R 1  is alkyl or alkylthio-group; R 2  is C 1 -C 8 -alkylthio-group possibly substituted with one or some halogen atoms or radical -CO-Z where Z is a free carboxyl radical or that converted to salt or ester; R 3  is radical   where X means oxygen atom or radical of the formula (a)   (radicals D 1 ,D 2  and R 5  have values given in p. 1 of the invention claim) and also their acid addition salts. Synthesized compounds show antagonistic properties to receptors of angiotensin-II, in part, they inhibit vasoconstrictive effect and trophic effect at the level of myocytes. Invention describes 3 methods of synthesis of compounds of the formula (I), pharmaceutical composition and intermediate compounds. EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 11 cl, 66 ex
The present invention relates to a use of a flavonoid morin compound for alleviating nuclear deformation of aged cells by inhibiting progerin-lamin A/C binding, and it has been confirmed that the flavonoid morin, a natural substance, interferes with the direct binding between progerin and normal lamin. As a result, it has been found that morin returns an abnormal nucleus shape to a normal nucleus shape, eventually giving old cells the properties of young cells. The action of morin is not due to antioxidant action, but is due to the combination with progerin, so it has a novel mechanism. In other words, the present invention has focused on nuclear dysfunction, rather than antioxidant activity, among human aging factors. To this end, a natural product, morin, has been found as a substance which inhibits the combination of progerin and lamin, and an anti-aging mechanism of morin has been identified through follow-up studies. Accordingly, the present invention may be used as a useful pharmaceutical composition and health functional food for preventing and treating Hutchinson-Gilford progeria syndrome (HGPS).
Patients receive nivolumab IV over 30 minutes on day 1 and paclitaxel IV over 1 hour on days 1, 8, and 15. Cycles repeat every 4 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of blood at baseline and on study, CT scan, spiral CT, or MRI, or FDG-PET scan throughout the trial.
Eccentric aerobic exercise group: Participants in this group will participate in an eccentric aerobic exercise rehabilitation program for a total of eight weeks, two sessions per week. Outcome measurements will be taken post exercise program and also after a 3 month follow-up period. Each session will be approximately 60 minutes in duration and include approximately 10 minutes of warm up (stretches), eccentric stepper aiming for 20 minutes, walking and light weights, followed by a five minute cool-down period.
OBJECTIVES: Tinnitus in children and adolescents is relatively unexplored territory. The available literature is limited and the reported prevalence of tinnitus suffering varies widely due to the absence of a definition for pediatric tinnitus. The impact on daily life seems to be lower than in the adult population. It is unclear if children who suffer from tinnitus, like adults, also experience psychological distress like anxiety or depressive symptoms. A better understanding of tinnitus in children and its impact on daily life could provide more insight into the actual size of the problem and could give direction for future studies to investigate the cause of progression of tinnitus.
DESIGN: A cross-sectional study was performed using the Dutch Lifelines population-based cohort of people living in the north of the Netherlands. A total of 4964 children (4 to 12 years of age) and 2506 adolescents (13 to 17 years of age) were included. The presence of tinnitus suffering and behavioral outcomes were assessed with a single-item question and the Child Behavioral Checklist or the Youth Self Report questionnaire respectively. The associations of behavioral outcomes and tinnitus suffering were analyzed using univariate binary regressions.
RESULTS: The prevalence of tinnitus suffering in children was 3.3 and 12.8% in adolescents. Additionally, 0.3% of the children and 1.9% of the adolescents suffered a lot or extremely of their tinnitus. Externalizing and internalizing problems were associated with tinnitus in adolescents. Internalizing problems were associated with tinnitus in children.
CONCLUSIONS: The prevalence of tinnitus suffering in this sample of the general population is comparable to other population-based studies. A low percentage of children (0.3%) or adolescents (1.9%) suffered a lot or extremely of their tinnitus. Tinnitus suffering is associated with all behavioral outcome subscales in adolescents and with internalizing problems in children, although the effect sizes were very small. Future research should focus on achieving a consensus for the definition of pediatric tinnitus and on the development of a validated outcome measure.
Animal tissue is extratced with a non-ionic surfactant solution, is extracted with a fat solvent, is extracted with a non-ionic surfactant solution and is then washed with water; it is stated that the thus-treated tissue is more likely to be compatible with a tissue to which it is subsequently grafted and is far easier to store for long periods.  In a preferred procedure, animal bone is exercized under sanitary conditions, the bone is soaked in a sterilising solution of about 0.5 to 5.0% salt concentration, the bone is extracted with an aqueous surfactant solution containing about 0.5 to 2.0% of a pastial ester of a higher unsaturated fatty acid with an anhydride of a polyhydroxy alcohol surfactant, the bone is extracted with chleroform-methanol solution for about 20 to 30 hours, the bone is extracted with a further non-ionic aqueous surfactant solution, the bone is washed with continuously changing water for about 48 to 200 hours, and the washed bone is sterilized and then byophilized. Animal tissue includes bone, cartilage, tendon or fascia.  Fat solvents: chloroform, acetone, lower aliphatic alcohols such as methanols or mixtures of these.  Surfactants: partial esters of higher unsaturated fatty acids with anhydrides of polyhydroxy alcohols and polyoxyethylene derivatives thereof, particularly sorbitan mono-oleate polyoxyethylene and specified proprietary products.  For sterilisation there may be employed inter alia solutions containing, liquid b -propiolactone, or cathode irradiation.  Examples disclose detailed procedures.
The patient we present here had many clinical, morphological, and laboratory findings characteristic of acute leukemia. During the course of the disease, the diagnosis changed from acute leukemia to chronic small B-cell lymphoproliferative disease, a blastoid variant of mantle cell lymphoma, and finally to atypical plasma cell leukemia. Atypical plasma cell leukemia is a rare condition with aggressive biological behavior. Our patient relapsed a short time after achieving complete remission, in spite of aggressive therapy and autologous stem cell transplantation. During relapse, it was possible to morphologically identify malignant cells as being of plasma cell origin, although immature and atypical. Atypical plasma cell leukemia presents a diagnostic challenge as it may mimic other neoplasms both morphologically and clinically. It is also recognized that plasma cell neoplasm immunophenotype may not be entirely specific for its lineage where common diagnostic biomarkers are applied by immunohistochemistry or flow cytometry. Where this is the case, only focused investigation for plasma cell lineage will be more informative. This patient has unusual clinical presentation, a nondescript morphology of the circulating plasma cells, as well as an immunophenotype, detected by the initial panels used for flow cytometry and immunohistochemistry, that was not entirely specific for plasma cells. Such cases present a good reminder of the diagnostic complexity of atypical plasma cell leukemia and emphasize that plasma cell differentiation needs to be interrogated in cases where the initial work-up shows unusual results.
MCI is defined as an early stage of cognitive decline that lies between normal age-matched cognitive function and the onset of very mild forms of dementia, and is associated with a slight but noticeable decline in abilities such as memory and thinking skills. Listening effort testing (with pupillometry) and cognitive testing will be administered for this group - and after a 6-week period of hearing aid use, these measures will be re-tested.
PURPOSE:To provide a bath liquid capable of easily emulsifying the component of seasame in a bath, exhibiting excellent warmth keeping property, and having remarkable effect especially to an anemic woman, by grinding and kneading seeds of seasame, and putting a definite amount of the obtained paste in a bag made of filter cloth. CONSTITUTION:100pts. of sesame seed is ground and kneaded to obtain a paste, added with 0-30pts. of a crude drug and other additive, kneaded, and put into a bag made of filter cloth to obtain the objective bath liquid composed mainly of sesame. Since the fat or oil of the finely ground sesame is dispersed further finely in the bath uniformly by the emulsifying action of lecithin and arginine existing in the oil or fat component, and at the same time, the oxidation of vitamins can be suppressed by the sesamol contained in the component, the warmth keeping effect of vitamin E can be maintained stably even after the storage for a long period. The bathing component can be dispersed in water easily only by pressing the bag in the bath without using an emulsifier and dispersing agent.
The device useful in a shower device for regulating properties of flowing water, comprises a housing (20) having an inlet (21) and outlet (22) for conducting the water through the housing, and a water-impermeable mold body (40) arranged in the water flow and containing an active substance (41). The mold body is massive and the active substance is evenly distributed in the mold body. The mold body is removable and rotatable in a storage (30, 32). The mold body is rotatable around its longitudinal axis (L), which is corresponding to the direction of flow of the water. The device useful in a shower device for regulating properties of flowing water, comprises a housing (20) having an inlet (21) and outlet (22) for conducting the water through the housing, and a water-impermeable mold body (40) arranged in the water flow and containing an active substance (41). The mold body is massive and the active substance is evenly distributed in the mold body. The mold body is removable and rotatable in a storage (30, 32). The mold body is rotatable around its longitudinal axis (L), which is corresponding to the direction of flow of the water. A base plate is arranged with an opening perpendicular in the direction of flow behind the inlet. A storage in the form of a recess is arranged in the base plates at both points of the mold body. The mold body has the form of an octahedron, where the bottom surface of the octahedron arranged between the points has four edges, where the length of the edge is shorter than the length of the eight edges between the sides. The surface area of the octahedron is turned opposite to the points of the octahedron around the longitudinal axis. The eight edges of the sides of the octahedron are arranged between the surface area and the pointed ends at 25-30[deg] around the longitudinal axis of the octahedron. A magnet is arranged in the direction of flow behind the inlet and before the base plate. The mold body is formed from a duroplastic with the active substance. The housing is formed out of a thermoplastic. The active substance is a metal, a precious metal, a precious gem, a semi-precious stone, a vegetable component and/or a vegetable extract e.g. from medicinal plants, a mineral and/or a powder. The device is arranged between an armature and a shower line guiding to a shower head of the shower device. An independent claim is included for a mold body for a device for regulating properties of flowing water.
The invention discloses aqueous strippable nail enamel and a preparation method thereof. The aqueous strippable nail enamel comprises a strippable aqueous polyurethane dispersion, a coalescing agent, an aqueous wetting dispersant, an aqueous base material wetting agent, deionized water, aqueous color paste/pearl powder and a rheological additive. The preparation method comprises the steps of dispersing, stirring, adjusting viscosity, filtering and packaging. The aqueous strippable nail enamel disclosed by the invention takes strippable aqueous polyurethane dispersion resin as a film forming substance of the nail enamel; due to a special structure of the aqueous polyurethane dispersion, a whole piece of film can be formed, is strippable and cannot be torn apart; and the film is harmless to nails when applied to the aqueous nail enamel and is healthy and environment-friendly, and the nail enamel can be stripped at any time to change the nail enamel with other colors and is more popular with consumers. The aqueous strippable nail enamel can be used as daily disposable nail enamel on finger nails, can be kept for more than 7 days without shedding on toenails, and is excellent in adhesive force. The aqueous strippable nail enamel can achieve a balance between strippability and the adhesive force.
PREPIDIL Gel (dinoprostone) administered endocervically may stimulate the myometrium of the gravid uterus to contract in a manner similar to contractions seen in the term uterus during labor. Whether or not this action results from a direct effect of dinoprostone on the myometrium has not been determined. Dinoprostone is also capable of stimulating smooth muscle of the gastrointestinal tract in humans. This activity may be responsible for the vomiting and/or diarrhea that is occasionally seen when dinoprostone is used for preinduction cervical ripening.

In laboratory animals, and also in humans, large doses of dinoprostone can lower blood pressure, probably as a result of its effect on smooth muscle of the vascular system. With the doses of dinoprostone used for cervical ripening this effect has not been seen. In laboratory animals, and also in humans, dinoprostone can elevate body temperature; however, with the dosing used for cervical ripening this effect has not been seen.

In addition to an oxytocic effect, there is evidence suggesting that this agent has a local cervical effect in initiating softening, effacement, and dilation. These changes, referred to as cervical ripening, occur spontaneously as the normal pregnancy progresses toward term and allow evacuation of uterine contents by decreasing cervical resistance at the same time that myometrial activity increases. While not completely understood, biochemical changes within the cervix during natural cervical ripening are similar to those following PGE2-induced ripening. Further, it has been shown that these changes can take place independent of myometrial activity; however, it is quite likely that PGE2 administered endocervically produces effacement and softening by combined contraction-inducing and cervical-ripening properties. There is evidence to suggest that the changes that take place within the cervix are due to collagen degradation resulting from collagenase secretion as a response, at least in part, to PGE2.

Using an unvalidated assay, the following information was determined. When PREPIDIL Gel was administered endocervically to women undergoing preinduction ripening, results from measurement of plasma levels of the metabolite 13,14-dihydro-15-keto-PGE2 (DHK-PGE2) showed that PGE2 was relatively rapidly absorbed and the Tmax was 0.5 to 0.75 hours. Plasma mean Cmax for gel-treated subjects was 433 ± 51 pg/mL versus 137 ± 24 pg/mL for untreated controls. In those subjects in which a clinical response was observed, mean Cmax was 484 ± 57 pg/mL versus 213 ± 69 pg/mL in nonresponders and 219 ± 92 pg/mL in control subjects who had positive clinical progression toward normal labor. These elevated levels in gel-treated subjects appear to be largely a result of absorption of PGE2 from the gel rather than from endogenous sources.

PGE2 is completely metabolized in humans. PGE2 is extensively metabolized in the lungs, and the resulting metabolites are further metabolized in the liver and kidney. The major route of elimination of the products of PGE2 metabolism is the kidneys.