anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This observational study will include 240 participants (80 participants per country) from IGI region (Italy, Greece and Israel), children adolescents and young adults (12\> years old) with T1D that are on multiple daily injections or insulin pump and are scheduled to start using MiniMed 780G system. After a 7-day run-in period, participants will be evaluated with food intake log and adherence to Meditteranean Diet (MD) with PREDIMED questionnaire. One hour session on MD and healthy impact on Diabetes will be provided to all participants and will be assigned to initiate MiniMed 780G and followed for 12 weeks. HbA1c, CGM and Insulin Metrics, anthropometric measurements, body composition, blood pressure and lipid leves as well a gut microbioma will be performed at baseline and 12 weeks, after MiniMed 780G initiation. A 7-day food diary logbook will be collected to identify the amount and type of the food at baseline and at the end of the study. At baseline, at 6 and at 12 months, markers of endothelial and cardiovascular function will also be assessed. An extension phase will include additional 3 and 6, which concludes one year of follow-up.
PROBLEM TO BE SOLVED: To obtain a tape preparation excellent in percutaneous absorption, mucous membrane-permeating property and attaching property and having low irritation to skin by adding a rubber component or other copolymer, a liquid component and a medicine to a specific copolymer. SOLUTION: This tape preparation is obtained by providing a tacky agent layer formed of (A) 100 pts.wt. copolymer comprising (i) 25-90wt.% (meth)acrylic acid alkyl ester having 4-18C alkyl, (ii) 0-70wt.% (meth)acrylic acid alkyl ester having <=3C alkyl and (iii) 2-40wt.% N-vinyl-2-pyrrolidone, (B) 1-100 pts.wt. copolymer of a rubber component or (meth)acrylic acid with methyl (meth) acrylate, (C) 1-100 pts.wt. liquid component (especially preferably isopropyl myristate or isopropyl palmitate) compatible with the component A and (D) a medicine on one side of a support. Furthermore, a material capable of percutaneously permeating a biomembrane is used as the component D.
Patients receive paclitaxel albumin-stabilized nanoparticle formulation IV over 30 minutes and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Patients also receive WEE1 inhibitor AZD1775 PO daily on days 1, 2, 8, 9, 15, and 16.
The invention relates to a fully humanized single-domain antibody for resisting Galectin-3 and application thereof. The antibody has at least one of a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR 3. The antibody can be used for preparing cells or conjugates, diagnostic reagents or diagnostic kits, drugs or pharmaceutical compositions; the medicine or the medicine composition has the anti-tumor effect aiming at the positive tumor of human Gal-3. The invention obtains a fully human single-domain antibody of the targeted Galectin-3 by a phage display technology, and the antibody can specifically recognize human Gal-3 protein with high affinity. The antibody can be applied to flow detection and specifically recognizes human Gal-3 positive cells. The antibody can also be applied to immunohistochemical staining, specifically identifies human Gal-3 protein expressed in tumor tissues and pulmonary vascular tissues, and has potential application values in basic research and clinical pathological detection.
PURPOSE: Data regarding treatment options and their efficacy for metastatic paragangliomas (mPPGL) is limited. This study aims to report a single center experience in treating mPPGL, comparing the efficacy and safety of various treatment approaches.
METHODS: Retrospective analysis of patients with mPPGL treated at an Endocrinology Department of a cancer institute between January 2000 and October 2022.
RESULTS: We analyzed 25 patients with mPPGL, 8 pheochromocytomas and 20 paragangliomas (12% multifocal), followed for a median of 9 [4; 14] years. Surgical approach, aimed at the primary tumor or at debulking of metastases, was the only treatment achieving complete response: 87% in primary tumor and 87.5% with debulking of metastases. These were long-lasting results with a duration of 69 (23.8; 136.8) months in primary tumor removal and 35.1 (15.3; 41) months in metastases debulking. As for other therapeutic approaches, such as radioactive isotopes, tyrosine kinase inhibitors, chemotherapy and external beam radiotherapy, the main outcome was stable disease, with few partial responses. At the last follow-up, 66% of the patients were alive, 15.4% were in remission and 84.6% had stable disease. Median overall survival was 14 years. The 5-year and 10-year survival rates from primary tumor diagnosis were 77.9% and 66.9% respectively, and from metastasis diagnosis were 67.4% and 55.6%, respectively.
CONCLUSION: This is the only European single center analysis addressing outcomes of different therapies in mPGL. The results support surgery as a first-line treatment, being the only approach that may achieve complete response with satisfactory and long-lasting results.
The invention provides a disposable kit and an automatic chemical synthesis main machine. The disposable kit and the automatic chemical synthesis main machine are used for synthesizing a short-life radio-labeling medicine for disease diagnosis. The invention comprises two parts of the main machine and the kit. The kit is characterized in that a pipe communicated with a reagent or container is provided with a valve piece set which can be conveniently connected and disconnected with a valve piece of the chemical automatic synthesis main machine; the kit comprises a gas channel sealing interface which can be conveniently connected and disconnected with a gas channel sealing interface of the main machine; a container for holding the reagent and the container or pipe needing to be sealed in storage and transportation are provided with sealing devices which can be quickly opened; and the spatial position and the communication relation of the structure correspond to the particular synthetic reaction and the corresponding main machine structure. The main machine has corresponding characteristics. Under conditions of larger cost-performance ratio, the invention reduces the complex manual operation procedures before and after the synthesis and facilitates the in-site synthesis of the short-life chemicals.
This study will be assessing the treatment response using HP 129Xe MRI for patients undergoing Target Lung Denervation (TLD) in COPD patients. Subjects eligible to participate in this study are those who agree and have already consented to participate in the AIRFLOW-3 clinical trial for TLD treatment at Temple University Hospital. The intent of this study is to image lung function using HP 129Xe MRI in ten TLD subjects before and approximately three months post TLD procedure as an observational sub-study. Subjects willing to participate in this sub-study will have to consent to this study and plan for two MRI imaging sessions: one prior TLD and a follow-up at approximately three months post TLD procedure.

As part of this companion protocol at Penn, the aim is to image each subject twice, using a total of 2.5L of HP 129Xe gas administered over approximately 50 breaths during each visit. Using the dynamic image set acquired, the investigators will characterize each imaging voxel (approximately 4mm x 4mm x 4mm) in terms of its tidal volume (in mm3), functional residual capacity (in mm3), fractional ventilation (efficiency of gas exchange via ventilation, unit less), and what is defined as "arrival time", which can be also shown as 'tidal volume hysteresis', and corresponds to the area enclosed when the local tidal volume is plotted against the inhaled gas volume. The latter parameter is zero in a region that inflates and deflates perfectly in sync with the inhaled gas volume but grows in magnitude when the two are out of sync: e.g., in cases obstructed ventilation or air trapping. The subject will be coached to maintain a reasonably steady breathing cadence of 10-15 breaths per minute, depending on their size and natural breathing rate, but will be otherwise unconstrained with respect to breath timing and volume. Each imaging session will take approximately 30 minutes, including positioning in the MRI and inhalation of a small HP 129Xe dose for scanner calibration. The proposed dynamic HP 129Xe MRI technique allows for the quantification of fractional ventilation (FV), tidal volume (TV), functional residual capacity (FRC), arrival time (τ), apparent diffusion coefficient (ADC), and dissolved phase HP 129Xe information. Obtaining all of these parameters in a single scan session reduces the necessary amount of imaging gas while increasing accuracy by correcting artifacts associated with collateral ventilation and the slow filling of parenchyma in diseased lungs. Following the two imaging sessions, data will be analyzed and compared, including comparison with other lung function measuring techniques.
The oral health educational method of this group comprised a total of 63 adolescentes aged between 14 and 19 years who received oral health information through an audiovisual material produced especially to this research to offer a teaching medium capable of arousing the attention of its audience. The participants of this group also received an App for smartphone containing messages of reinforcement in oral health which was sent during a period of 30 days.
Resistance to chemotherapy remains the main challenge for cancer treatment. One of the mechanisms of tumor escape from cytotoxic agents could be the formation of cell-in-cell (CIC) structures, in which the outer cell protects the inner cell from unfavorable environment. Such structures have been found in many tumor types, however, their link to chemosensitivity is elusive. Here, we tested whether the CIC structures can promote resistance of colorectal cancer cells to chemotherapy. To identify CIC structures in cell cultures and in tumor xenografts, both transmission electron microscopy and confocal fluorescence microscopy of live and fixed cells as well as tissue slices and histopathology were used. Cytogenetic analysis was performed to detect chromosome instability associated with the drug resistance. It was found that in the five colorectal cancer cell lines intrinsic chemoresistance positively correlated with the ability of cells to spontaneously form CIC structures. Cultured cells treated with oxaliplatin and Irinotecan and tumor xenografts treated with FOLFOX or FOLFIRI regimens displayed an increased number of CICs after the treatment. The release of the inner cell from CIC structure was observed after removal of the drug. The number of CICs in the cell lines and tumors with acquired resistance to oxaliplatin was higher than in the drug-naive counterparts. The development of chemoresistance was also accompanied by the changes in the cell's ploidy. These preliminary data clearly demonstrate the associations of CIC structures with chemoresistance of colorectal cancer in cultured cells and tumor xenografts and show the prospect of further clinical validation of CICs as a potential prognostic marker for treatment efficiency.
Visual illusions have been studied in many non-human species, spanning a wide range of biological and methodological variables. While early reviews have proved useful in providing an overview of the field, they have not been accompanied by quantitative analysis to systematically evaluate the contribution of biological and methodological moderators on the proportion of illusory choice. In the current meta-analytical study, we confirm that geometrical visual illusion perception is a general phenomenon among non-human animals. Additionally, we found that studies testing birds report stronger illusion perception compared to other classes, as do those on animals with lateral-positioned eyes compared to animals with forward-facing eyes. In terms of methodological choices, we found a positive correlation between the number of trials during training or testing and the effect sizes, while studies with larger samples report smaller effect sizes. Despite studies that trained animals with artificial stimuli showing larger effect sizes compared with those using spontaneous testing with naturalistic stimuli, like food, we found more recent studies prefer spontaneous choice over training. We discuss the challenges and bottlenecks in this area of study, which, if addressed, could lead to more successful advances in the future.
Pre-assessment of active and passive range of motion in the paretic ankle, and five strides of gait assessment on a pressure-sensitive mat. Intervention will be moderate grade III anterior-to-posterior directed ankle mobilization for 2 minutes while supine, ankle muscle stretch for 75 seconds in standing, ankle muscle training for 3 minutes while seated. Post-assessment is repeated in the same sequence and content as pre-assessment.
The intervention group trained bimanual coordination once a day for about 31 minutes on a total of ten days using a tablet game. A ball is to be moved on a circular line.
The present invention belongs to the pharmaceutical field, and relates to a pharmaceutical composition for preventing and treating NITM and a pharmaceutical use thereof. Specifically, the pharmaceutical composition is an ophthalmic pharmaceutical composition, such as an ophthalmic formulation. Specifically, the present invention relates to a pharmaceutical composition comprising 0.001% - 0.2% of atropine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable adjuvants. The pH value of the pharmaceutical composition is 4.0 - 6.5. The pharmaceutical composition comprises 0.5% - 5% of a pH adjusting agent selected from any one or more of sodium dihydrogen phosphate, disodium hydrogen phosphate, citric acid, citrates, boric acid and borates. The pharmaceutical compositions of the present invention are capable of treating and/or preventing NITM effectively, having good application prospects.
<P>PROBLEM TO BE SOLVED: To provide an immunostimulating composition which can be prepared from rice bran at high yield and has high immunostimulating performance.  <P>SOLUTION: The immunostimulating composition contains as an effective ingredient, a water-soluble fraction obtained through the processes of: (1) performing a sterilizing treatment of the rice bran after adding water thereto; (2) inoculating the yeast derived from the rice bran and lactic acid bacteria into the sterilization-treated rice bran to ferment; (3) treating the fermented rice bran with a polysaccharide-degradative enzyme; and (4) extracting and collecting the water-soluble fraction from the resultant treated substance. The polysaccharide-degradative enzyme is preferably at least one selected from the group consisting of cellulase, hemicellulase and pectinase. Further, it is preferable that the yeast is Pichia sp-01 (accession No. FERM P-21702) and lactic acid bacterium is Enterococcus sp-L3 (accession No. FERM P-21703).  <P>COPYRIGHT: (C)2010,JPO&INPIT
PEX168,200µg,Subcutaneous injection,once a week. Metformin,0.5mg, tid,oral.
PURPOSE: This study aimed to determine the association between functional impairment in small airways and symptoms of dyspnea in patients with Long-coronavirus disease (COVID), using imaging and computational modeling analysis.
PATIENTS AND METHODS: Thirty-four patients with Long-COVID underwent thoracic computed tomography and hyperpolarized Xenon-129 magnetic resonance imaging (HP Xe MRI) scans. Twenty-two answered dyspnea-12 questionnaires. We used a computed tomography-based full-scale airway network (FAN) flow model to simulate pulmonary ventilation. The ventilation distribution projected on a coronal plane and the percentage lobar ventilation modeled in the FAN model were compared with the HP Xe MRI data. To assess the ventilation heterogeneity in small airways, we calculated the fractal dimensions of the impaired ventilation regions in the HP Xe MRI and FAN models.
RESULTS: The ventilation distribution projected on a coronal plane showed an excellent resemblance between HP Xe MRI scans and FAN models (structure similarity index: 0.87 ± 0.04). In both the image and the model, the existence of large clustered ventilation defects was not identifiable regardless of dyspnea severity. The percentage lobar ventilation of the HP Xe MRI and FAN model showed a strong correlation (ρ = 0.63, P < 0.001). The difference in the fractal dimension of impaired ventilation zones between the low and high dyspnea-12 score groups was significant (HP Xe MRI: 1.97 [1.89 to 2.04] and 2.08 [2.06 to 2.14], P = 0.005; FAN: 2.60 [2.59 to 2.64] and 2.64 [2.63 to 2.65], P = 0.056).
CONCLUSIONS: This study has identified a potential association of small airway functional impairment with breathlessness in Long-COVID, using fractal analysis of HP Xe MRI scans and FAN models.
Sterile paper points will be inserted into the root canal at 3 time points: (i) before instrumentation, (ii) after washing the canal with 10% sodium thiosulfate, and (iii) after the EdgePro Laser root canal therapy has been completed. The paper points will collect bacteria, which will be analyzed via real-time Polymerase Chain Reaction to assess bacterial counts.
Phantom pain is a chronic painful condition that affects patients with amputations. Treatment for phantom pain is often disappointing. In amputees, hyperexcitability of the posterior parietal cortex area (PPC) contralateral to the side of the amputation has been linked with the presence of phantom sensations. PPC is an area overactive in different forms of chronic pain too. It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain, a condition poorly responsive to available treatments. We have previously demonstrated that low frequency TMS (1 Hz) results in decreased excitability of the stimulated cortical regions. We plan to apply low-frequency TMS to PPC cortical areas contralateral to the side of the amputated limb. We expect that this intervention will result in amelioration of the phantom pain. Stimulation of the PPC area (target intervention) will be compared with a control intervention in which TMS is directed slightly away from the head.
Provided is a host factor specific for hepatitis B virus (HBV) infection. The specific host factor CREBH can remarkably enhance HBV infection. The specific host factor can, on the one hand, enhance entry of HBV, and on the other hand, enhance transcription of HBV to some extent. In the CREBH regulatory pathway there is a specific host factor SCARF2. During HBV infection, an N-terminus EGF-like domain of SCARF2 plays a crucial role in the infection and entry of HBV. The two correlated specific host factors provide a new target for inhibiting HBV infection.
The present invention relates to systems and components for infusing a medicament, such as insulin. In general, the invention as used herein relates to systems and components for infusing a medicament, such as insulin. The system components typically include a cannula adapted for subcutaneous insertion into a diabetic patient. The system also includes a fluid conduit adapted to deliver the insulin solution from the drug reservoir to the infusion site, and a reservoir in operable contact with the fluid conduit. The reservoir comprises a selected material including a site loss mitigating agent (such as heparin) that inhibits inflammation at the infusion site and encapsulation of the cannula at the infusion site. A site loss mitigating agent is not pre-mixed with the insulin but is adapted to contact the insulin solution in the reservoir as it flows from the drug reservoir to the infusion site.
The effect of chronic overcrowding on the social behavior of adult male Wistar rats was studied. From postnatal day 30 (P30) to P180, the rats lived under standard (STND) or overcrowded (CRWD) conditions. Starting from P100, rat behavior was studied in the social preference and tube dominance tests, and aggressive behavior was investigated in the resident-intruder test. After decapitation of rats on P180, amygdala, dorsal hippocampus, ventromedial hypothalamus, and medial prefrontal cortex were collected and analyzed for expression of the IL-1β, TNF, TGF-β1, and IL-6 mRNAs by quantitative polymerase chain reaction. Compared to the STND group, rats from the CRWD group demonstrated shorter interaction time with a social object in the social preference test. They also had more wins in the tube test and initiated more attacks in the resident-intruder test. Expression of the IL1β gene in the hippocampus and medial prefrontal cortex and of the TGFβ1 gene in the hippocampus, amygdala, and prefrontal cortex was increased in the CRWD group. The stress induced by overcrowding increased social dominance and aggressiveness and decreased social motivation in rats. The changes in the social behavior of CRWD rats were accompanied by upregulation of expression of genes for the proinflammatory cytokine IL-1β and the anti-inflammatory cytokine TGF-β1 in a number of brain structures, which can be considered as manifestations of neuroinflammation and compensatory processes, respectively.
Participants will receive a single 0.5 mL subcutaneous injection of V114 administered at 2 to 6 months of age, and second and third dose is administered at an interval of ≥27 days from the prior dose. The fourth dose is administered at 12 to 15 months of age.
INTRODUCTION: Complexity in healthcare systems has been arbitrarily defined as tasks or systems ranging from complicated to intractable, with a general view of these not being 'simple'. Complexity in healthcare systems in first-world countries has been well elucidated, however, data from third-world countries is still scant. MATERIALS AND METHODS: We present four cases each from three different organ systems-chronic kidney disease, alcohol use disorder, and heart failure-in the backdrop of our healthcare organization. We present our analysis of the complexities faced clinically and, in our local healthcare system which led to these events.
RESULTS: Analysis of these cases showed that patients with chronic kidney disease had vertebral-spinal pathologies due to poor infection control measures during haemodialysis. All these patients were young with a long history of secondary hypertension. In patients with alcohol use disorder, a common theme of how government regulations and peer pressure promote alcohol use is analysed. In the four patients with unexplained heart failure, vascular health is viewed as a fractal dimension and the various factors affecting vascular health are elaborated.
CONCLUSION: Complexities exist clinically in making a diagnosis, and organizationally, in the variables and nodes dictating patient outcomes. Clinical complexities cannot be simplified but have to be navigated in an optimized way to improve clinical outcomes.
Alzheimer's disease (AD) is a condition initiated by the assimilation of β-amyloid plaques (Aβ) and tau tangles, leading to neurodegeneration. It involves frequently cognitive decline as well as memory impairment in patients. Efforts in therapeutic interventions are currently facing challenges in identifying targets within this scaffold that can significantly alter the clinical course for individuals with AD. Moreover, in AD, neurons release a protein called endostatin, which accumulates in Aβ plaques and enhances AD. This accumulation of Aβ in the triggers a cascade of events leading to synaptic dysfunction, neuroinflammation, and ultimately neuronal death. Environmental factors nowadays increase the risk of AD with prolonged exposure of heavy metals such as copper (Cu), lead (Pb), mercury (Hg), cadmium (Cd), and other pesticides. It has been observed that these factors can cause the aggregation of Aβ and tau which initiates the plaque formation and hence leads to enhanced pathogenesis of AD. This review summarizes the interlinking between heavy metals, environmental factors, pesticides, endostatin, and progression of AD has been deliberated with recent findings.