anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Meticulous antimicrobial management is essential among critically ill patients with acute kidney injury, particularly if renal replacement therapy is needed. Many factors affect drug removal in patients undergoing continuous renal replacement therapy CRRT. In this study, we aimed to compare current databases that are frequently used to adjust CRRT dosages of antimicrobial drugs with the gold standard. The dosage recommendations from various databases for antimicrobial drugs eliminated by CRRT were investigated. The book 'Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by the Kidneys' was chosen as the gold standard. There were variations in the databases. Micromedex, UpToDate, and Sanford had similar rates to the gold standard of 45%, 35%, and 30%, respectively. The Micromedex database shows the most similar results to the gold standard source. In addition, a consensus was reached as a result of the expert panel meetings established to discuss the different antimicrobial dose recommendations of the databases.
BACKGROUND: Missed opportunities to reduce numbers of primary major lower-limb amputation and increase limb-salvage procedures when treating chronic limb-threatening ischaemia have previously been identified in the literature. However, the potential economic savings for healthcare providers when salvaging a chronic limb-threatening ischaemia-affected limb have not been well documented.
METHODS: A model using National Health Service healthcare usage and cost data for 1.6 million individuals and averaged numbers of primary surgical procedures for chronic limb-threatening ischaemia from England and Wales in 2019-2021 was created to perform a budget impact analysis. Two scenarios were tested: the averaged national rates of major lower-limb amputation (above the ankle joint), angioplasty, open bypass surgery or arterial endarterectomy in the National Vascular Registry (current scenario); and revascularization rates adjusted based on the lowest amputation rate reported by the National Vascular Registry at the time of the study (hypothetical scenario). The primary outcome was the net impact on costs to the National Health Service over 12 months after the index procedure.
RESULTS: In the current scenario, the proportions of different index procedures were 10% for lower-limb major amputation, 55% for angioplasty, 25% for open bypass surgery and 10% for arterial endarterectomy. In the hypothetical scenario, the procedure rates were 3% for major lower-limb amputation, 59% for angioplasty, 27% for open bypass surgery and 11% for arterial endarterectomy. For 16 025 index chronic limb-threatening ischaemia procedures, the total care cost in the current scenario was €243 924 927. In the hypothetical scenario, costs would be reduced for index procedures (-€10 013 814), community care (-€633 943) and major cardiovascular events (-€383 407), and increased for primary care (€59 827), outpatient appointments (€120 050) and subsequent chronic limb-threatening ischaemia-related surgery (€1 179 107). The net saving to the National Health Service would be €9 645 259.
CONCLUSION: A shift away from primary major lower-limb amputation towards revascularization could lead to substantial savings for the National Health Service without major cost increases later in the care pathway, indicating that care decisions taken in hospitals have wider benefits.
The experimental group received additional NMES during exercise. According to a previous study, the unit's electronics created electrical impulses with an output frequency of 80 Hz and a duration of 200 ms. The synchronous (S) mode and asymmetrical rectangular wave-pulse were used throughout the experiment. The amplitude was set as muscle motor-level contraction with the self-perception of maximal tolerable intensity. A rise and fall time of 2s with a tetanic muscle stimulation lasting 8 seconds and a 3s duration between stimulations were used for all participants.
Commonly consumed vegetable fats and oils are comprised predominantly of TAG, and small amounts of DAG and monoacylglycerol. TAG consists of 3 fatty acid ester, whereas diacylglycerol oil has 2 fatty acid esters linked to a glycerol backbone. Recently, Watanabe et al., developed a process by which the ratio of glycerides found in plant oils such as soybean, canola (rapeseed), or corn can be shifted from TAG to DAG, leading to the formation of oil composed largely of DAG. Commercially, DAG oil is produced by esterification of fatty acids derived from natural edible plant oils in the presence of lipase enzyme. Commercially produced vegetable DAG oil contains \>80% DAG, \<20% TAG, \<5% monoacylglycerols, and small amounts of emulsifiers and antioxidants to maintain quality. The main constituent fatty acids of DAG oil are oleic (C18:1), linoleic (C18:2), and linolenic (C18:3) acids, present as 1,3- and 1,2 (or 2,3)-DAGs in a ratio of 7:3, respectively. These structural differences may be responsible for the purported metabolic effects of DAG compared to TAG oil, DAG oil has fewer fatty acids than TAG, and DAG-oil with a greater proportion of DAG in the sn-1,3 versus sn-1,2 form may be more readily oxidized. Thus, the effects of DAG oil on increasing LDL-C would be expected to be less than TAG oil.
Store famotidine injection, USP at 2° to 8°C (36° to 46°F). If solution freezes, bring to room temperature; allow sufficient time to solubilize all the components. Protect from light. Retain in carton until time of use.

Although diluted famotidine injection, USP has been shown to be physically and chemically stable for 7 days at room temperature, there are no data on the maintenance of sterility after dilution. Therefore, it is recommended that if not used immediately after preparation, diluted solutions of famotidine injection, USP should be refrigerated and used within 48 hours (see DOSAGE AND ADMINISTRATION).
The present invention relates to a plaster for treating hyperosteogeny, which has the formula of raw sichuan axonite root, raw wild aconite, long-noded pit viper, frankincense, myrrh, trogopterus dung, chuanxiong rhizome, notopterygium root, himalayan teasel root, safflower, panpax notoginseng, pangolin, asarum herb, pubescent angelica, garden balsam stem and camphor. The medicine materials (except for the camphor) are pulverized into powder of 120 meshes. Sesame oil is heated until the sesame oil is refined to the degree of dripping water into pearls, and lead monoxide is added for being stirred into a plaster shape. The temperature of the sesame oil is reduced to 70 DEG C, and medicine powder is added for being evenly stirred into a plaster of which the temperature is then reduced to 40 DEG C. The camphor is added into the plaster for even stirring, and then, the plaster is spread out. Each plaster weights 30g. The plaster of the present invention is used for treating hyperosteogeny, old injuries, rheumatism arthralgia pain and hypertrophic spondylitis.
Chronic myeloid leukemia (CML) treatment with Bcr-Abl tyrosine kinase inhibitors (TKIs) has significantly improved patient outcomes, yet challenges such as drug resistance and persistence of leukemic stem cells persist. This study explores the potential of naringenin, a natural flavonoid, to enhance the efficacy of Bcr-Abl TKIs in CML therapy. We showed that naringenin reduces viability of a panel of CML cell lines regardless of varying cellular origin and genetic mutations, and acts synergistically with dasatinib and ponatinib. Importantly, naringenin is effective in targeting blast crisis CML CD34+ cells by decreasing their colony formation, self-renewal and viability. Compared to CML, naringenin is significantly less effective against normal bone marrow (NBM) counterparts. In addition, naringenin significantly enhances the inhibitory effects of dasatinib in CML but not NBM CD34+ cells. Mechanism studies showed that naringenin's inhibitory effects were associated with the induction of oxidative stress and lipid damage, as evidenced by increased reactive oxygen species (ROS) and malondialdehyde (MDA) levels. Notably, naringenin upregulated genes related to mitochondrial biogenesis while downregulating antioxidant defense genes. Pretreatment with α-tocopherol, which inhibits lipid-mediated ROS production, completely abolished the ROS increase and restored cell viability, indicating that lysosomal lipid peroxidation plays a crucial role in naringenin's mechanism of action. In a CML xenograft mouse model, the combination of naringenin and dasatinib resulted in remarkably more tumor growth suppression compared to single drug alone. Importantly, this combination was well-tolerated, with no adverse effects on body weight observed. These findings suggest that naringenin, by inducing oxidative lipid damage, enhances the anti-leukemic effects of Bcr-Abl TKIs, offering a promising therapeutic strategy for CML.
Increasing complexity of medical interventions and critical care treatment in an elderly getting population requires precise and accurate hemodynamic monitoring.(1) However, advanced invasive hemodynamic monitoring is often combined with complications by arterial or central venous catheterization. Complications such as vessel harming, infection, cardiac arrhythmias and nervous lesions are likely to occur.(2-4) Therefore, in the past various techniques of minimal- or non-invasive hemodynamic monitoring devices have been evaluated.(5, 6) One of the very promising technique is continuous non-invasive blood pressure monitoring by applanation tonometry. Published data revealed efficacy of this technique. (7) However, ability of this technique remains unclear in patients suffering from cardiological pathologies leading to changing stroke volumes as in arterial fibrillation, to highly reduces stroke volume as in severe impaired left-ventricular function or in severe aortic valve stenosis. Further, ability of applanation tonometry in patients without having pulsatile blood flow such as in patients with left-ventricular assist device remains unclear. Therefore, validation of this technique should be performed in the presented study.

Further development of applanation tonometry including pulse contour analysis now enables assessment of cardiac output. However, till now there is limited data assessing validation cardiac output measurement by this method. Cardiac output validation should also be performed in the planed clinical study.
BACKGROUND: Attention Deficit/Hyperactivity Disorder (ADHD) is one of the most common disorders in school-aged children. Learning disorder (LD) is also one of the most important psychiatric disorders in children, which can often be associated with ADHD. In this study, we sought to compare self-esteem and quality of life in 8 to 12-year-old children with attention deficit/hyperactivity disorder with and without co-occurring learning disorders in order to emphasize the importance of attention and diagnosis in children with ADHD.
METHOD: Among the 8- to 12-year-old outpatients referred to the child and adolescent psychiatry clinic of Omid Babol Clinic, 120 children aged 8 to 12 years with attention deficit/hyperactivity disorder whose disease was diagnosed by a child and adolescent psychiatry subspecialist. Among the tools used to collect information was the Colorado Learning Difficulties Questionnaire by Wilcott et al. (CLDQ), five-scale self-esteem test of Pepe et al. (1989) for children and quality-of-life questionnaire for 8-12-year-old children (PedsQL).
RESULTS: This study investigated self-esteem and quality of life in children with ADHD (n = 120, 51.7% boys). Children with ADHD and learning disabilities reported significantly lower self-esteem and quality of life compared to those with ADHD alone.
CONCLUSION: Considering the relatively high probability of co-occurrence of ADHD and learning disorders, if one of them is diagnosed in a child, it is possible to look for other disorders in the child in order to avoid the more severe negative effects that this co-occurrence can have on the child by diagnosing it as soon as possible.
Uses for treating, preventing and/or managing amyloidosis. Specific embodiments encompass the use of an immunomodulatory compound alone or in combination with an additional active ingredient. The invention further relates to reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the use of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and commercial packages suitable for use of the invention are also disclosed. In one embodiment, immunomodulatory compound is a compound of the formula (see formula I).  In another embodiment, the immunomodulatory compound is a compound of the formula (see formula II).
Gas-related symptoms (GRS) such as abdominal bloating, flatulence, and belching are some of the most common gastrointestinal complaints posed by the general population. These are hallmark symptoms in patients with functional gut disorders like irritable bowel syndrome but have also been linked to conditions such as gut hypersensitivity, altered gut microbiota and altered gut motility. The main issue with grasping the full impact of these symptoms on a patients' quality of life is that they are largely subjective and thus almost impossible to standardize. However, given their pervasiveness there is merit attempting to gauge their severity in as objective a manner as possible in order to track disease progress and response to treatment. GRS can be widely irregular and requiring patients to call into the office to answer questionnaires post treatment or keep handwritten logs to turn in later can lead to inaccurate data collection that can hinder accurate diagnosis and management. The ubiquitous nature of smartphones and user-friendly interfaces of electronic applications allow for information to be logged/accessed remotely and securely, each log would have their own time stamp and be recorded in an organized, consistent manner.
Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.
The present invention relates to a health record system for simply and accurately organizing, in one place, medical information existing across several hospitals and enabling a patient to transmit symptom information of the patient to a medical institute (H) even without knowing medical terms. The health record system according to the present invention comprises: a reception module (100) for receiving medical data (210) comprising medical information generated by the medical institute (H); a data conversion module (200) for extracting letter-type data (220) from the medical data (210); a visualization module (300) for generating image-type data (310) by using the letter-type data (220) extracted by the data conversion module (200); a display module (400) for displaying the image-type data (310) to a user; and a storage and transmission module (500) which stores and transmits data generated by the reception module (100), the data conversion module (200), and the visualization module (300). The image-type data (310) generated by the visualization module (300) is characterized in being a preset two-dimensional or three-dimensional model. The data conversion module 200 is characterized in collecting the medical data (210) by receiving data from one or more of a mobile file, a hospital, a cloud server, and a personal device. The visualization module (300) is characterized in expressing, by one or more of a color, brightness or transparency, a pattern, and a texture (320) of visualization data, the name of a disease, the severity, the degree of acuteness and chronicity, and the degree of malignancy of the disease, various types of test results, a function test result, and a data result extracted from a machine. The visualization module (300) is characterized in using, as the texture (320), an image or anatomical pathology picture extracted from a medical image.
The invention belongs to the technical field of farm chemicals, and relates to a pyrithiobac sodium-paraquat weeding composition, and application thereof. The paraquat-pyrithiobac sodium compounded herbicide has a wide herbicide controlling spectrum, a long lasting period and an obvious weeding effect. The weeding composition comprises two active ingredients of pyrithiobac sodium and paraquat on the mass ratio of (10-50):(1-10). A dosage form of the weeding composition can be wettable powder, soluble powder or water dispersible granules. According to the invention, the herbicide controlling spectrum of the simplex pyrithiobac sodium or the simplex paraquat is broadened, the weeding efficiency is enhanced, and the resistance of some weeds to the paraquat is relieved. The pyrithiobac sodium-paraquat weeding composition is applicable to ploughing-free weeding in non-cultivated lands, forests and fruit gardens and before seeding dry-land crops such as cotton, soybeans, wheat, rapeseed, corn and the like, and is also applicable to inter-row weeding of the cotton, the corn, sugarcane and the like after seedling.
A method for the Internet of Things refers to objects to exchange information over the Internet. An IoT system refers to one or more IoT objects that exchange information and, through those exchanges, produces information that meets an objective or purpose, including the actuation of mechanical systems. An IoT system that refers to a single IoT object may also be referred to as an IoT device. The capability of an IoT systems refers to the information produced by the system to achieve its objective or purpose. The present embodiments may be implemented by computer software on a networked digital computer or a dedicated microprocessor, connected to a digital network. The embodiments create descriptions of IoT systems and provides a means of searching over these descriptions for those satisfying search criteria and a means of composing two or more descriptions to form a description of the composition of IoT systems.
This is a single-site, unblinded, historically controlled, first use in humans study of a stoma barrier with a new formulation. Approximately 34 subjects who are currently using a 2-piece tape bordered product and able and willing to wear a product will be enrolled. Each participant is provided with one box containing 20 of the test barriers to be used consecutively according to their normal routine. Each participant is also provided with a box containing 30 pouches selected to most closely resemble their current product. Participants are asked to record the time of application and time of removal of each test barrier and their assessment of relevant characteristics for each test barrier. A clinical evaluation of the peristomal skin is conducted at study entry, at approximately mid way through the study and again at its conclusion. Photographs are taken of the peristomal skin at each visit using a digital camera. Individual participation in terms of wearing the barrier is for 30 days or until the test barrier has been used up, whichever comes first. The study is comprised of 3 visits, an enrolment visit, a mid-study visit and a completion visit and a phone call at approximately day 7.
A system for controlling a device includes a remote control and a safety control that communicate with each other through a wireless connection. The remote control device may be configured to remotely control the apparatus and include a switch, a motion-enabling unit, and a manual control unit. The motion enabling unit may be configured to generate the processed information by processing the information using the first key. The manual control unit is capable of acquiring the processed information from the motion-enabling unit only when the switch is in the closed state. The manual control unit may be configured to transmit the processed information to the safety control device via a wireless connection. The safety control device may include a communication unit and a safety control unit. The communication unit may be configured to receive the processed information over a wireless connection. The security control unit may be configured to verify a closed state of the switch by processing the processed information using a second key matching the first key, and to initiate control of the device when the closed state of the switch is verified.
The active group shall consist of a minimum of 40 patients with a confirmed diagnosis of COPD and osteoporosis or osteopenia. All patients shall receive a 16-week twice weekly PR programme which shall be followed by a 36-week maintenance home exercise programme. All patients were medically stable and referred by their caring respiratory consultant.
A liquid, water-repellent, substantially anhydrous, spray-pumpable skin protectant composition is disclosed. The composition is designed for spraying directly onto skin, has suitable adherence to the skin, and resists running. The composition contains one or more actives, one or more rheology modifiers, and a carrier. The rheological modifiers can be waxes and/or associative thickeners such as some forms of silica. The carrier can be mineral oil or a mineral oil replacement (e.g., isohexadecane, cyclomethicone). Film-forming components also help the composition resist running. One indication for which the composition may be formulated is diaper rash. The active ingredient for diaper rash may be dimethicone and preferably also zinc oxide.
Typical-hearing controls. Speech recognition testing: Listening to and repeating speech in the free field in a sound-attenuated booth. We track percent-correct scores for whole sentences and words within each sentence. Changes in the participant's pupil size will be monitored by an Eyelink eye tracker placed 50 cm from the eyes. Phasic pupil dilations are linked with experiment timing landmarks interpreted as changes in listening effort.
The invention provides a method for preparing a traditional Chinese medicine (TCM) for treating pus and blood type colitis, belonging to the technical field of TCM preparation methods. At present, norfloxacin is generally adopted to treat pus and blood type colitis, but such adverse reactions as gastrointestinal symptoms, reduction of rash and leukocyte and elevation of transient transaminase areeasy to occur after norfloxacin is used. The method is characterized by taking radix scutellariae, coptis root, amur corktree bark, broomjutre sida herb, starwort root, creeping oxalis, buckthorn, veronicastrum herb, Daghestan sweet clover herb, coix seed, coffee senna, common alstonia bark leaf, common lophatherum herb, pale butterflybush flower, mung beans, dandelion, orpine, thalictrum simplexL. var. brevipes hara, shrubby breynia, small-leaved desmodium, wintercherry, jeffersonia dubia, uniflower swisscentaury root, olive, small-leaved lemmaphyllum, creeping rostellularia herb, garcinia, potentilla discolor bge, ilex rotunda thunb and liquorice, soaking the above 30 TCMs into water and then decocting the TCMs with slow fire, thus obtaining the decocted soup, namely the TCM for treating pus and blood type colitis. The method has the following advantages that the prepared liquid TCM has low toxic or side effect, short course of treatment and high recovery rate and avoids the adverse reactions, allergic reactions and toxic reactions caused by the antibacterial western medicines.