anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments. This was originally described in Japan but is increasingly recognized all over the world especially in older women. There is evidence to support that excess sympathetic activation and catecholamine surges are potential mechanisms that cause this temporary myocardial 'stunning'. The amount of catecholamines in circulation of patients with SC was 2 to 3-fold higher when compared to subjects with acute myocardial infarction related equivalent cardiac dysfunction \[Wittstein, et al. NEJM, 2005\].

In this institution over the last two to three years the investigators have identified more than a dozen patients with stress cardiomyopathy. This diagnosis has been confirmed by echocardiographic documentation of normalization of left ventricular function over a course of few days to weeks. The investigators' overarching goal is to further characterize these individuals with the hope of identifying risk factors and developing strategies to prevent the occurrence of SC in situations where the likelihood in susceptible individuals may be high.
The “Artificial Intelligence-Based Virtual Assistant for Hospital Management” is a transformative system revolutionizing healthcare administration. Employing adaptive machine learning algorithms, the virtual assistant dynamically optimizes appointment scheduling, considering historical data, real-time factors, and patient preferences. Natural language processing ensures seamless communication with patients and facilitates dynamic rescheduling. An intelligent patient record management module securely organizes unstructured data, enhancing access for healthcare professionals. The system automates billing and insurance processing with AI oversight, identifying discrepancies and ensuring regulatory compliance. Real-time resource allocation dynamics optimize bed utilization based on predictive analytics. An emergency response coordination module interprets and prioritizes messages, initiating protocols during critical events. The system offers an adaptable user interface with real-time analytics. This invention marks a significant leap in healthcare technology, fostering efficiency, accuracy, and patient-centricity in hospital management.
Disclosed are branched water-soluble polymers that allow two or more water-soluble polymers to be conjugated to another species. Particularly disclosed is an amino acid having the formula (I), wherein: A is a member selected from O, NH and S; R11, R11', and R12 are independently selected from H, alkyl groups, and water-soluble polymer moieties, with the proviso that at least two of R11, R11', and R12 are water-soluble polymer moieties; and R14 is a member selected from an OH group, a group comprising a saccharide moiety, s is an integer selected from between 1 and 5. The branched polymers provide access to therapeutic agents that are conjugated at a single site to two or more water-soluble polymers. The branched polymers are based upon branch points that are simple branched alkyl structures, reactive side-chain amino acids and small peptides of reactive side-chain amino acids, and saccharides. Also disclosed is a method for preparing mono-disperse poly(ethylene glycol) of a well-defined and determinable molecular weight, and a method for the rational end-functionalization of poly(ethylene glycol). Conjugates of the branched water-soluble polymers with diverse species, e.g., peptides, lipids, glycolipids and small molecules are also provided.
No intervention during 6 months after inclusion. After the 6 month follow-up evaluation the study subjects are offered to participate in the interventional arm.
BACKGROUND: Developing countries have a significantly higher incidence of breast cancer in patients younger than 40 years as compared to developed countries. This study aimed to examine if young age at diagnosis is an independent prognostic factor for worse survival outcomes in breast cancer as well as the effect of age on Disease-free survival (DFS) and local recurrence free survival (LRFS) after adjusting for various tumor characteristics, local and systemic treatments.
METHODS: This is a secondary analysis of prospective cohort of patients from two existing databases. We identified patients with breast cancer aged 40 years or less and we matched them to those older than 40 years. We also matched based on stage and molecular subtypes. In cohort 1, we matched at a ratio of 1:1, while in cohort 2 we matched at a ratio of 1:3.
RESULTS: In cohort 1, Disease-free survival (DFS) at 5 years was significantly shorter for those younger than 40 years (75.6% and 92.7% respectively; p < 0.03). On multivariate analysis, only chemotherapy was found to be significant, while age was not found to be an independent predictor of prognosis. Local recurrence free survival at 5 years was similar between both age categories. Only hormonal therapy is a significant predictor for LRFS at 5 years. In the second cohort, DFS and LRFS at 3 years were similar between those younger and those older than 40 years. On multivariate analysis, no factor including age was found to be an independent predictor of prognosis.
CONCLUSION: Data in the literature is controversial on the effect of young age on breast cancer prognosis. Our findings could not demonstrate that age is an independent prognostic factor in our population. There is a need for outcomes from larger, prospective series that have longer follow-ups and more data from our region.
The present invention relates to a fleece flower root product with no bitter and astringent flavor and a preparation method. The present invention relates to a granular or powdery product prepared by soaking, fumigating and stir-frying fleece flower root. Soaking liquid of water or wine of the product is used for preparing oral medicinal liquid, beverage wine, beer or blended wine, and can be used as food additives directly used for fermenting roast wine or being prepared into single fleece flower root medicines in the mode of tablets or powder. The preparation method comprises the steps that fleece flower root is cleaned, sliced and soaked in water for 1 to 3 days, and then the fleece flower root is taken out and cleaned; the fleece flower root is fumigated for 6 to 8 hours, and after being taken out and aired to the dryness of 70 to 80%, the fleece flower root is fumigated for the second time for 6 to 8 hours; the process is repeated in this way, multiple times until no bitter or astringent odor exists in the fleece flower root, and then the fleece flower root is dried in the sun, pulverized and stir-fried with fragrance; the fleece flower root is cooled, packaged and put in a warehouse. The product of the present invention has multiple functions: when soaked in water and drunk, the product has the function of reducing weight, and distilled wine brewed by fermentation has the advantages of good transparence, heavy wine fragrance and excellent mouth feel. The present invention provides a new technical choice for developing fleece flower root resources.
BACKGROUND: Dilated cardiomyopathy (DCM) is characterized by enlarged, weakened heart ventricles due to chronic fibrosis. Dysfunctional senescent myofibroblasts and excessive citrullination have been implicated in fibrotic diseases. Peptidylarginine deiminases (PADs) are involved in the citrullination of ECM proteins. However, their role in regulating the cellular functions of cardiac myofibroblasts in DCM, is not well understood. This study aimed to evaluate the role of PADs in the cellular biology and fibrotic behavior of myofibroblasts in DCM.
RESULTS: Aged cardiac myofibroblasts derived from dilated cardiomyopathy (DCM, N=5) and healthy (HCF, N=3) participants (35-60 years), were cultured in TGFB-conditioned medium and treated with an irreversible pan-PAD inhibitor BB-Cl-amidine. Our findings showed that, compared with HCFs, DCM myofibroblasts showed high expression of PAD-2, PAD-3, citrullinated proteins and ECM proteins (vimentin, fibronectin, actin, and b-Tubulin). BB-Cl-amidine-mediated PAD inhibition directly affected the cell biology of DCM myofibroblasts, as shown by the reduced migration and invasion of DCM myofibroblasts. It also augmented the apoptosis by activating caspase-3 and decreased senescence by regulating p-53. PAD inhibition did not affect the citrullination of vimentin or fibronectin; however, it decreased collagen 1 A expression.
CONCLUSIONS: This study revealed that elevated PAD expression facilitates cellular processes mainly senescence, migration, and invasion. PAD inhibition resulted in the downregulation of these cellular functions, thereby reducing the fibrotic behavior of DCM myofibroblasts.
The ketone bodies acetoacetate, β-hydroxybutyrate (βHB) and acetone are small lipid-derived molecules that are produced in the liver under certain conditions such as starvation, very low carbohydrate intake and prolonged glycogen-depleting exercise. Ketone bodies serve as an alternative energy substrate for the brain and other metabolically active tissues under periods of low glucose availability, and can modulate carbohydrate and lipid metabolism. Previously, controlled physiological ketosis required a low carbohydrate diet, starvation or administration of acetoacetate (AcAc) salts which were all unpleasant or potentially harmful. The development of ketone esters provides an alternative method to increase βHB levels, and has been shown to be well tolerated in rodents and humans. Two examples are the R,S-1,3-butanediol acetoacetate diester and the (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester. Ingestion of either have been shown to result in short-term (0.5-6 hours) nutritional ketosis (βHB \>1mM). Nutritional ketosis can therefore be achieved without the need for the impracticality of ketogenic dieting or fasting.

In recent years there has been considerable interest in ketone body food supplements due to their potential for improved exercise performance and therapeutic glucose lowering effects in people with type 2 diabetes. Exogenous ketone supplements may be of particular interest for individuals living with type 1 diabetes by serving as an alternative fuel substrate to reduce the reliance on glucose utilisation and spare endogenous glycogen and reduce the risk of hypoglycaemia in certain situations, such as exercise. Stubbs et al. (2017) found that drinks containing exogenous ketones were a practical and efficacious way to raise blood βHB levels with only a modest change in acid-base balance in healthy individuals without diabetes (after 60 min, blood pH declined from 7.41 to 7.31 following a ketone ester drink). To date, no studies have investigated the metabolic effects of ketone in people with type 1 diabetes.
A hair treatment process for improved and milder oxidative treatment of hair, especially human hair. It was found out that when commonly used oxidative treatment compositions are mixed with another composition comprising predominantly carboxylic acids, the dyeing and/or bleaching effects of the compositions are improved, homogeneous dyeing/bleaching of hair fibres is achieved and natural cosmetic properties of hair is maintained. A process comprises applying onto hair a ready-to-use composition obtained by mixing compositions A comprising one or more alkalising agents and having a pH of 7.5 to 12, B being an aqueous composition comprising one or more oxidising agents and having a pH of 1.5 to 5 and C comprising (i) one or more carboxylic acids or salts thereof having 3 or more carboxyl groups and (ii) one or more additional organic acids and/or salts thereof having one or two carboxyl groups. Composition C comprises (i) and (ii) at a concentration of 10 to 100% by weight. The ready-to-use composition has a pH of 8 to 11, comprises (i) and (ii) at a concentration of 1 to 10% by weight and is prepared by mixing A, B and C in a weight ratio in the range of 1:2:0.2 to 1:1:1. A kit for hair comprises compositions A, B and C.
BACKGROUND AND OBJECTIVES: Pregnant women commonly experience challenging nausea and vomiting, which significantly affect their general well-being and daily life. Although medication is often used for relief, it may not alleviate symptoms completely, emphasizing the need for complementary therapies. Acupuncture is one of the complementary treatments for nausea and vomiting of pregnancy (NVP). Studying the outcomes of acupuncture for NVP can shed light on this issue and inform treatment guidelines. Therefore, we systematically evaluated the effectiveness and safety of acupuncture in managing NVP, considering the traditional meridian and acupoint theories.
METHODS: PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, ClinicalTrials.gov, and the Chinese Clinical Trial Registry were searched on May 1, 2024. Randomized controlled trials (RCTs) that compared acupuncture for NVP with sham acupuncture, placebo, and Western medicine (WM) or acupuncture plus WM with WM alone were included. The risk of bias was assessed using the Cochrane risk-of-bias tool. A meta-analysis was conducted using RevMan 5.4.1, and the quality of evidence for each outcome was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation approach.
RESULTS: Twenty-four RCTs (with 26 publications) involving 2390 women were included. Acupuncture plus WM significantly led to a reduction in Pregnancy-Unique Quantification of Emesis (PUQE) scores and ineffective rates compared with WM alone (PUQE: mean difference [MD] -1.95, 95 % confidence interval [CI] -3.08 to -0.81, P = 0.0008, I2 = 90 %, six studies; ineffective rates: risk ratio [RR] 0.27, 95 % CI 0.19 to 0.39, P < 0.00001, I2 = 7 %, 16 studies). It also resulted in a greater improvement in ketonuria, shorter length of stay, and lower scores on the NVP Quality of Life and Chinese Medicine Syndrome Scale. Acupuncture was superior to WM in terms of reduction in ineffective rates (RR 0.50, 95 % CI 0.30 to 0.81, P = 0.006, I2 = 0 %, five studies). Acupuncture and WM had comparable results in improvement in PUQE scores (MD -0.80, 95 % CI -3.06 to 1.46, P = 0.49, I2 = 89 %, three studies) and ketonuria negative rates. The evidence is not clear regarding the impact of acupuncture on depression and anxiety compared with that of sham acupuncture. The incidence of severe adverse events was not significantly different between acupuncture and WM or sham acupuncture. Evidence certainty ranged from moderate to very low. Of the 24 RCTs, 19 used the Neiguan (PC6) acupoint, 16 used the Zusanli (ST36) acupoint, and 13 used the Zhongwan (CV12) acupoint.
CONCLUSION: According to the current systematic review and meta-analysis, acupuncture combined with WM may be a more effective treatment for NVP than WM alone. Furthermore, acupuncture may be as effective as WM. PC6, ST36, and CV12 are the most commonly used acupoints. Although more robust and larger studies are required, the current evidence supports the use of acupuncture in NVP treatment, as it has been demonstrated to be safe.
The present disclosure relates to methods for preparing anti-TNF antibodies (e.g., anti-tnfa antibodies) (golimumab)), a method of operating a chromatographic column in a method of manufacturing the same, and a specific pharmaceutical composition of an antibody. The method involves collecting column outlet signals and cumulative flow parameters at two or more intervals of at least one flow phase transition front during operation of a chromatography column comprising column packing. A model γ cumulative distribution curve is determined based on the collected column outlet signals and the cumulative flow parameters of the at least one flow phase transition front. The parameters of the model gamma cumulative distribution curve are used to calculate theoretical plate equivalent Height (HETP) values for at least one flow phase transition front and the mass of the chromatographic column packing is estimated based on the calculated HETP values. If adverse trends in HETP or exceeding control limits are observed during conventional column monitoring, eluted product quality, column process performance and should be evaluatedAnd/or impurity removal data to ensure product quality of the identified lot. If either of the product quality or column performance fails to meet the standard setting, appropriate corrective actions, such as adjusting, recharging or replacing the column, and authenticating should be performed before releasing for further use.
MOTIVATION: Pediatric kidney disease is a widespread, progressive condition that severely impacts growth and development of children. Chronic kidney disease is often more insidious in children than in adults, usually requiring a renal biopsy for diagnosis. Biopsy evaluation requires copious examination by trained pathologists, which can be tedious and prone to human error. In this study, we propose an artificial intelligence (AI) method to assist pathologists in accurate segmentation and classification of pediatric kidney structures, named as AI-based Pediatric Kidney Diagnosis (APKD).
RESULTS: We collected 2935 pediatric patients diagnosed with kidney disease for the development of APKD. The dataset comprised 93 932 histological structures annotated manually by three skilled nephropathologists. APKD scored an average accuracy of 94% for each kidney structure category, including 99% in the glomerulus. We found strong correlation between the model and manual detection in detected glomeruli (Spearman correlation coefficient r = 0.98, P < .001; intraclass correlation coefficient ICC = 0.98, 95% CI = 0.96-0.98). Compared to manual detection, APKD was approximately 5.5 times faster in segmenting glomeruli. Finally, we show how the pathological features extracted by APKD can identify focal abnormalities of the glomerular capillary wall to aid in the early diagnosis of pediatric kidney disease.
AVAILABILITY AND IMPLEMENTATION: https://github.com/ChunyueFeng/Kidney-DataSet.
BACKGROUND: Care partners of people with serious illness experience significant challenges and unmet needs during the patient's treatment period and after their death. Learning from others with shared experiences can be valuable, but opportunities are not consistently available.
OBJECTIVE: This study aims to design and prototype a regional, facilitated, and web-based peer support network to help active and bereaved care partners of persons with serious illness be better prepared to cope with the surprises that arise during serious illness and in bereavement.
METHODS: An 18-member co-design team included active care partners and those in bereavement, people who had experienced serious illness, regional health care and support partners, and clinicians. It was guided by facilitators and peer network subject-matter experts. We conducted design exercises to identify the functions and specifications of a peer support network. Co-design members independently prioritized network specifications, which were incorporated into an early iteration of the web-based network.
RESULTS: The team prioritized two functions: (1) connecting care partners to information and (2) facilitating emotional support. The design process generated 24 potential network specifications to support these functions. The highest priorities included providing a supportive and respectful community; connecting people to trusted resources; reducing barriers to asking for help; and providing frequently asked questions and responses. The network platform had to be simple and intuitive, provide technical support for users, protect member privacy, provide publicly available information and a private discussion forum, and be easily accessible. It was feasible to enroll members in the ConnectShareCare web-based network over a 3-month period.
CONCLUSIONS: A co-design process supported the identification of critical features of a peer support network for care partners of people with serious illnesses in a rural setting, as well as initial testing and use. Further testing is underway to assess the long-term viability and impact of the network.
The present invention belongs to the technical field of medicine. The present invention relates to a dual-targeting anti-hepatic fibrosis medicine carrier, namely pseudoglucoprotein nanoparticles. More specifically, the present invention relates to 6-phosphoric acid-mannitose derivative albuminoid nanoparticles and a preparation method thereof. The following figure shows the chemical structure general formula, wherein R represents a substituent group on an aromatic nucleus, and M represents thio carbonyldiamide an orazo group. The neoglycoprotein nanoparticles of the present invention can be used as a medicine carrier. Firstly, the nanoparticles carrying the anti-hepatic fibrosis medicine are passively targeted to the liver by the phagocytosis of macrophages of reticuloendothelial systems at the liver, the spleen, etc. The neoglycoprotein nanoparticles can enter the interior of cells under the action of athrocytosis particles by the specific combination of a specific ligand formed by structure qualification and a receptor of mannitose-6-phosphoric acid/insulin-like growth factor (M6 P/IGFII) in hepatic stellate cells (HSC). The effective transfer carrier of the neoglycoprotein nanoparticles, which is used as a medicine to arrive at the HSC, makes the hepatic fibrosis medicine fully exert the function in the HSC so as to greatly improve the therapeutic effect of the medicine.
BACKGROUND: Difficult airway, characterized by difficult mask ventilation and intubation, is common in obese patients undergoing surgery. The purpose of this study was to evaluate and compare the prognostic efficiency of ultrasound-measured anterior cervical soft tissue parameters as an indicator of difficult airway during anesthesia induction in obese patients.
METHODS: This prospective, double-blind, observational study was conducted at Balikesir University Faculty of Medicine Hospital between March 2020 and March 2022. A total of 157 patients age ≥ 18 (BMI ≥ 30 kg.m-2), without previous head and neck surgery were included in the study. Anterior cervical soft tissue measurements were performed at three levels; minimum distance between the hyoid bone and skin at the level of the hyoid bone; (DSHB), distance between the midpoint of the epiglottis and skin at the level of the thyrohyoid membrane; (DSE), distance between the anterior commissure of vocal cords and skin at the vocal cord level; (DSV). The Han scale was used to assess difficult mask ventilation and the Cormack-Lehane scale was used to assess difficult laryngoscopy.
RESULTS: In the difficult laryngoscopy group, the mean values of DSHB, DSE and DSV were 18.5 ± 3.5, 18.3 ± 3.8, and 18.6 ± 3.4, respectively. The AUC values for DSHB, DSE, and DSV were 0.845, 0.827, and 0.850, respectively. Anterior cervical measurements showed a better predictive value for difficult laryngoscopy compared to difficult mask ventilation.
CONCLUSION: Ultrasonographic measurements were predictive for difficult laryngoscopy and ventilation with better correlation in laryngoscopy.