anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: It is known that cerebral palsy (CP) children's caregivers suffer from burden, depression, and stress, impairing their quality of life (QoL). The more severe the CP, the more burden the caregiver has. Psychosocial support, education, therapies, and financial support are inversely related to the level of stress of the caregiver. Most parents of CP patients submitted to selective dorsal rhizotomy (SDR) report improvement not just on spasticity, but also in the functional role of the children, what can impact on caregiver's QoL. Our objective was to evaluate the burden of CP children's caregivers with and without previous SDR.
METHODS: Spastic CP children caregivers were divided into two groups: those who take care of children without previous SDR (control group) and those that children were previously submitted to SDR (surgical group). The burden index was compared between groups using Burden Interview Questionnaire (BIQ). For statistical analysis, we used SPSS.
RESULTS: The control group had enrolled 31 participants and the surgical group 36. The mean GMFCS level on the control and surgical groups was 3.94 ± 1.26 and 3.74 ± 1.12 (p = 0.61), respectively. The surgical group caregivers presented less burden related to the feeling that they should be doing more to their child (p = 0.003) and if they could do a better job in caring (p = 0.032), compared to controls. The total BIQ index was not significantly different between groups (surgical 32.14 ± 12.34 vs. control 36.77 ± 12.77; p = 0.87). Low economic status had a weak correlation to a higher BIQ index (R2 = 0.24). After age-matching, there was a significative higher BIQ index in the control group (p = 0.008).
CONCLUSION: Caregivers of spastic CP children who were previously submitted to SDR presented less burden related to feeling of the amount of given care than those without previous surgery. The impression that they could do a better job with their kids was higher in the control group. The severity of CP and low economic status were related to more burden in both groups. After pairing groups by age, the control group had a significative higher BIQ index compared to the SDR group.
CLINICAL TRIAL REGISTRATION: Trial registration number: CAAE 73407317.6.0000.0068 (Ethical and Research Committee of University of Sao Paulo, Sao Paulo, Brazil, approved on 08/06/2021). All the subjects were freely given an informed consent to participate in the study that was obtained from all participants. Non-consented ones were excluded from the study.
In the past, various technologies for eliminating a virus or inhibiting replication of a virus have been proposed. Such proposals, for examples, includes a proposal of using silver, a proposal of using a quaternary ammonium, a proposal of using a metal hydroxyl pyrithione, a proposal of using a sulfonic acid group and so on. However, these proposals may not be satisfied in performance for solving problems such as discoloration, heat resistance, anti-virus and others. In view of this status, the present invention is completed accordingly. The purpose of the present invention is to provide: an anti-virus material which has no problem of discoloration due to silver, but having excellent heat resistance, and high antiviral properties for a wide range of virus patterns, and to provide an anti-viral material-containing anti-virus product. The solution according to the present invention is an anti-viral material comprising a polymer having a H-type carboxyl group and H-type sulfonic acid group, or a mixture of a polymer having H-type carboxyl group, and a polymer having a H-type sulfonic acid group.
The primary care physicians will receive access to an online course on hypertension management based on the ACC/AHA and ESC guidelines. They will also receive feedback reports on their performance on hypertension management for 16 weeks.
PURPOSE: A micro composite particle containing crystalline celecoxib and pharmaceutically acceptable polymers is provided to improve release property, physiochemical stability, and processability. CONSTITUTION: A micro composite particle contains crystalline celecoxib and pharmaceutically acceptable polymers. The shape of the particle is spherical form. The average size of the particle is 20-400 um. The melting point of the composite is 150-165°C. The content of the polymers is 5-50wt%. The polymers are polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylic acid, or pluronic F-127. A method for preparing the micro composite particles comprises: a step of mixing a celecoxib solution and the polymers to prepare a mixture solution; and a step of mixing the mixture solution and cerecoxib non-solvent and crystallizing.
Atherosclerosis (AS) is a chronic inflammatory disease caused by the deposition of lipoproteins and sequent immune responses. Within the atherosclerotic plaque, macrophages are the most abundant immune cells and play a great part as protagonists and promoters of AS. In the past decade, the concept of 'trained immunity' has emerged, which highlights the memory characteristics of innate immunity, thus opening up a new avenue of research. Evidence suggests that trained immunity may regulate the onset and progression of AS with trained macrophages playing an important and dynamic role in atherogenesis. The present review provided a summary of concepts related to trained immunity and its relationship with AS. Furthermore, different phenotypes of macrophages responding to various stimuli within the atherosclerotic plaque were presented, along with the complex mechanisms of metabolic and epigenetic reprogramming in the cells. Finally, several promising therapeutic approaches for AS cardiovascular disease were discussed, which may shed light on new clinical strategies.
NEW MATERIAL:A (meth)acrylate monomer shown by the formula (R is H or methyl). EXAMPLE:4-Methacryloxysalicylic acid. USE:An adhesive for metals and the teeth and a coating compound having high bond strength, water resistance and adhesion durability. PREPARATION:For example, 2,4-dihydroxybenzoic acid is dissolved in water in the presence of sodium hydroxide and reacted with a solution of methacrylic acid chloride in chloroform by dripping the solution in a nitrogen gas flow in an iced water bath while stirring. After the reaction is over, the reaction solution is separated into a chloroform layer and a water layer and chloroform is distilled away to give crude crystal, which is recrystallized to give a compound shown by the formula. The compound is blended with a comonomer and a radical polymerization initiator and a curable composition for adhesive, etc., can be obtained.
This information processing system comprises a portable terminal. The portable terminal detects sensor information for assessing a user's emotions. It would be permissible, as an example, for the sensor information to be sound information which is detected by a microphone, or image information which is captured by a camera. The information processing system assesses the user's emotions on the basis of the sensor information. The portable terminal detects the sensor information in a period when the said portable terminal is in a standby state. As an example, the said standby state is a state wherein a display of the portable terminal is off.
In DMD; as a result of mutations in the Xp21.2 region of the dystrophin gene, which encodes the dystrophin protein, which plays an important role in the normal contraction and relaxation of the muscle, progressive weakness starting from the proximal extremity muscles, chronic degeneration, replacement of the muscle with fat and connective tissue occurs due to the production of deficient or fully functional dystrophin. Although motor performance is one of the most prominent features in children with DMD, it has been reported that cognitive functions are also significantly affected in one third of children compared to their healthy peers. In addition, the physical activity levels of children with DMD show a significant decrease in physical activity levels after the age of 5, when motor problems are more pronounced than their healthy peers. Recently, interest in studies on physical activity level and cognitive skills in pediatric neuromuscular diseases such as DMD has increased, and studies have revealed the relationship between cognitive functions and motor performance. There are also studies showing that the effect on motor performance over time is associated with a decrease in physical activity level. However, there are no publications that directly examine the relationship between cognitive functions and physical activity level in children with DMD. Therefore, the primary aim of our study is; to investigate the relationship between physical activity level and cognitive functions in children with DMD. The secondary aims of our study are to reveal the relationship between balance and body mass index and physical activity level in children with DMD.
Toripalimab 240mg,d1,q3w+Anlotinib 12mg/d,d1-14,q3w+Etoposide 100mg/m2,d1-3,q3w+Cisplatin 75mg/m2 or Carboplatin AUC=5, d1, q3w,4-6 cycles in total. After the end of the first-line treatment, patients with CR, PR, and SD can continue to maintenance treatment with Toripalimab 240mg,d1,q3w+Anlotinib 12mg/d, was taken orally for 2 weeks and stopped for 1 week until the disease progressed.
PURPOSE:To facilitate the business procedure for delivery of drugs by providing a bar code reader which describes previously a bar code including the identification information on drugs onto a 2nd order slip and inputs the bar code information at ordering of drugs. CONSTITUTION:A bar code shows the identification information on drugs written previously on a 2nd order slip, and bar code reader 6 inputs the bar code infor mation. In other words, a bar code 2Y showing a drug to be delivered is previ ously displayed on a slip (e.g., a statement of delivery) attached to the drug to be delivered out of those order slips 2 against the drug to be delivered from a deliverer. The reader 6 fetches the code 2Y after delivery and reception. Thus the reception of the drug is through. In such a constitution, a drug receiv ing operation is simplified and no keyboard nor its operator are required for input of the delivery/reception information.
Despite the worldwide prevalence and huge burden of pain, pain is an undertreated phenomenon. Currently used analgesics have several limitations regarding their efficacy and safety. The discovery of analgesics possessing a novel mechanism of action has faced multiple challenges, including a limited understanding of biological processes underpinning pain and analgesia and poor animal-to-human translation. Computational pharmacology is currently employed to face these challenges. In this review, we discuss the theory, methods, and applications of computational pharmacology in pain research. Computational pharmacology encompasses a wide variety of theoretical concepts and practical methodological approaches, with the overall aim of gaining biological insight through data acquisition and analysis. Data are acquired from patients or animal models with pain or analgesic treatment, at different levels of biological organization (molecular, cellular, physiological, and behavioral). Distinct methodological algorithms can then be used to analyze and integrate data. This helps to facilitate the identification of biological molecules and processes associated with pain phenotype, build quantitative models of pain signaling, and extract translatable features between humans and animals. However, computational pharmacology has several limitations, and its predictions can provide false positive and negative findings. Therefore, computational predictions are required to be validated experimentally before drawing solid conclusions. In this review, we discuss several case study examples of combining and integrating computational tools with experimental pain research tools to meet drug discovery challenges.
Upon examining the literature, it was found that the incidence of delirium after open heart surgery ranged from 3% to 70% (Tomakin et al., 2020). Postoperative delirium has numerous risk factors, including predisposing and accelerating factors. Predisposing risk factors comprise malnutrition and electrolyte imbalance, cognitive impairment, depression, and other psychiatric disorders such as dementia (Velayati et al., 2019; Wilson et al., 2020). This study aims to investigate the relationship between the nutritional status of patients undergoing open heart surgery and the development of postoperative delirium. The study will be conducted in the Cardiovascular Surgery Intensive Care Unit of Bursa Uludag University Health Application and Research Centre Hospital between September 2023 and February 2024. Data will be collected using the Personal Information Form, Nutritional Risk Screening Score 2002 (NRS-2002), Delirium Risk Assessment Form, Visual Analogue Scale for Pain Levels, Richmond Agitation Sedation Scale, Glasgow Coma Scale, and Confusion Assessment Scale in Intensive Care Unit.
The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Speci fically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least (5) percent by weight of alprazolam, estazolam, midazolam or triazolam. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least (5) percent by weight of alprazolam estazolam, midazolam, or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route to a mammal is provided which comprises : a) a composition comprising at least (5) percent by weight of alprazolam, estazolam, midazolam or triazolam; and, b) a device that forms an alprazolam, estazolam, midazolam or triazolam containing aerosol from the composition, for inhaltion by the mammal.
The present invention relates to alpha la and/or alpha id adrenergic receptor antagonists of formula (I). Compounds described herein can function as alpha la and/or alpha id adrenergic receptor antagonists and can be used to treat. diseases or disorders mediated through alpha la and/or alpha id adrenergic receptors. Compounds described herein can also be used to treat benign prostatic hyperplasia or related symptoms thereof. Compounds described herein can also be used to treat lower urinary tract symptoms associated with or without benign prostatic hyperplasia. Also described herein are processes to prepare the described compounds, as well as pharmaceutical compositions thereof and methods of treating benign prostatic hyperplasia or related symptoms thereof.
Same as USUAL CARE arm, plus financial incentive as follows: groups (or "cohorts") of 6 smokers each will be formed on a rolling basis, linking individuals with target quit dates (day "0's") near each other. If participants quit smoking by their target quit date, and that is confirmed by cotinine or anabasine tests, they will receive a monetary award from the study investigators. On top of that, participants will receive an additional monetary amount for each member of their group who also quits smoking. These participants will interact through a chat room, which will help motivate them to quit smoking.
The invention belongs to the technical field of medicines, and particularly discloses application of picrorhizin nitrone in preparation of a medicine for preventing and treating asthma. The invention establishes an OVA-induced mouse asthma animal model, and researches the anti-inflammatory, anti-oxidation and trachea-relaxing effects of the picrorhizin nitrone by using research methods such as an integral animal experiment, an in-vitro trachea experiment and the like. Test results prove that the picrorhizin nitrone can obviously improve the lung tissue inflammation and the lung tissue injury caused by the lung tissue inflammation of an asthma model mouse, inhibit the generation of inflammatory cytokines and reduce the lung wet/dry weight ratio and the lung permeability index. Increasing the level of superoxide dismutase and glutathione in lung tissue homogenate, reducing the level of lipid peroxidation product malondialdehyde, and improving the oxidative stress state of lung. Reduce the tension of smooth muscle of isolated trachea and improve the tracheal spasm. The picrorhizin nitrone can be used as an active ingredient to be mixed with a pharmaceutically acceptable carrier or excipient to prepare a pharmaceutical composition for preventing and treating asthma.
PURPOSE:To obtain testosterone-5alpha-reductase inhibitor containing a plant extract of Rosa rugosa Thunb., Saxifraga stolonifera Meerburg, Garcinia mangostana L., etc., as active ingredients and useful for androgenic alopecia, acne, prostatic hypertrophy, etc. CONSTITUTION:The objective inhibitor containing one or two or more kinds of extracts from Rosa rugosa Thunb, Saxifraga stolonifera Meerburg, Garcinia mangostana L., Nephelium lappaceum L., Pyrola japonica Klenza, Trichosanthes cucumeroides Maxim, Kadsura japonia Dunal, Cuscuta australis R. Br., Cuscuta japonica Choisy, Euchresta japonica Benth., Lilium makinoi Koidzumi and balbatimone, a wild herb as active ingredients. The extracts are extracted using water or hydrophilic organic solvent (e.g. methanol). The inhibitor can be prepared in a form of lotion, tonic, spray, solution, ointment, etc. The inhibitor is administered at a dose of 1mg to 1g/human once to several times daily in the case of treating prostatic hypertrophy and administered at a dose of 10mug to 50mg/human once to several times daily in the case of treating alopecia and acne.
A 55-year-old woman suffered from diplopia and occipital pain after shoveling snow. She was diagnosed with the right vertebral artery dissecting aneurysm at the level of the axial vertebra and repeatedly had cerebral infarctions in the posterior circulation. She had subluxation of the atlantoaxial vertebra as an underlying disease. Right vertebral angiogram with the head rotated to the left showed the right vertebral artery occlusion and left vertebral angiogram with the head rotated to the right showed stenosis at the C1-C2 level, leading to the diagnosis of Bow hunter's stroke. After wearing a cervical collar and taking 100 ‍mg of aspirin, she had no recurrence of cerebral infarction and later underwent C1-C2 posterior fusion to prevent the recurrence of cerebral infarction. She finished taking aspirin 6 months after the surgery, and there has been no recurrence of cerebral infarction. We report here a case of Bow hunter's stroke, a rare disease, with good clinical outcomes after C1-C2 posterior fusion.
Ethics committee approval was received on 12 December 2019, numbered 19/344. The study was planned to include 90 adult patients undergoing diabetic foot surgery at Gülhane Training and Research Hospital between 12 December 2019 and February 2020. These patients were divided into three groups: sciatic nerve block (Group B), continuous nerve catheter (Group C). Group B patients underwent preoperative popliteal ultrasound guided peripheral nerve blockage. 20 ml of 0.25% bupivacaine was administered. In Group C patients, 20% bupivacaine 20 ml was applied to the sciatic nerve with a peripheral nerve catheter and continuous infusion was started with patient controlled analgesia device. Preoperative and postoperative blood flow of the popliteal and tibialis posterior arteries, pain scores of patients were evaluated with numeric rating scale and wound healing was monitored and recorded. The differences between the groups were compared statistically.
Tea tree oil is the essential oil obtained from the Australian plant Melaleuca alternifolia. The oil has been used in Australia for many decades as a topically applied antiseptic and has been used to treat bites, stings, cuts and grazes. Many studies have shown that tea tree oil has both antimicrobial and anti-inflammatory activity in the laboratory. In addition, clinical trials have demonstrated that the oil can help in treating conditions such as dandruff, tinea, colonisation with methicillin resistant Staphylococcus aureus (MRSA) in the nose and acne. Together, these laboratory and clinical studies indicate that tea tree oil can potentially be used to treat relatively minor skin infections or diseases.

This pilot study aims to investigate whether a commercially available gel containing tea tree oil is effective for treating mild to moderate facial acne. A minimum of 18 participants that meet the inclusion and exclusion criteria will be enrolled in the study. Participants will be instructed to apply the tea tree oil gel each morning and night for 12 weeks and their acne will be assessed after 4, 8 and 12 weeks of treatment. Acne severity will be measured by (1) counting the numbers of lesions (pimples) on the face and (2) assigning an overall acne severity score. The lesion counts and severity scores at 4, 8 and 12 weeks will be compared to the baseline count to evaluate whether the acne is improving.

Potential benefits to participants, and of the study, are that their acne may improve as a result of treatment and that the results of the study may provide evidence that a commercially available product is effective for treating acne. There are many over-the-counter topically applied products available for treating acne. Two of the most common active ingredients are benzoyl peroxide and salicylic acid. Benzoyl peroxide is an antibacterial agent that works by killing the P. acnes bacterium on the skin. Although it is relatively effective for treating acne, it can also be quite irritating, especially when patients first start to use it. Salicylic acid acts by helping to unblock pores and remove excess dead skin thus helping pimples to heal more quickly. However, it is generally not as effective as benzoyl peroxide. One previous study has shown that a gel containing 5% tea tree oil performed similarly to benzoyl peroxide for reducing pimples, suggesting that it warrants further study.

Since a small percentage of people (approximately 1.4%) are allergic to tea tree oil all participants will be monitored for any reactions to the study product. Tea tree oil allergy typically manifests as redness and swelling and the site of application. This is one of the possible risks to participants, however, given the small numbers of study participants the likelihood of one or more participants having a reaction to the oil is low. Another possible risk is that participants may not benefit from the treatment and that their acne may not improve.
Fiber pentose or a composition containing fiber pentose is used in the manufacture of foods or medicines for preventing and/or treating acidification of the body in diabetic patients. The composition comprises fiber pentose and substances that promote absorption in the body of fiber pentose. The substances that promote absorption of fiber pentose are selected from cellulose, vitamin B1, vitamin B5, vitamin B6, thyroxine, adrenalin, potassium ion, magnesium ion and sodium ion. The fiber pentose is xylose, ribose, arabinose, lyxose, ribulose and/or xylulose. The fiber pentose is prepared by mixing cellulose-containing biomass, water and catalyst, hydrolyzing and then fermenting with yeast. The catalyst is selected from hemicellulose hydrolase, organic acid, inorganic acid or biomimetic catalyst.