anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine, microbiology, food industry. SUBSTANCE: probiotic composition promises live non-lyophilized bacterial mass of the strain Enterococcus faecium L-3 in the amount 1 x x 10 5  CFU per a single dose, not less, or its mixture with strain or strains of useful microorganisms and fatty component of a base that comprises additionally a friable component in the ratio = (1:1)-(1:10) with a fatty component. Bacterial mass and fatty component of a base are taken in the ratio providing high content of useful microflora, 1 x 10 5  CFU per a single dose, not less. For culturing the bacterial mass the isolated soybean protein "Supro Plus 2640" is taken, medium is centrifuged, precipitate is separated and dried by contact drying method that is carried out on starch and/or talc, and/or rice meal, and/or other small-dispersed powder-like mass at temperature below +45 C up to formation of friable mass that is mixed with neutral fats that are useful for microflora and for human skin and mucosa tissues. Invention provides preparing probiotic composition for new curative-prophylactic agents and foodstuffs using vigorous and active bacterial mass of live microorganisms as components of the composition that confers to these agents high therapeutic effect due to ability to suppress pathogenic microflora and to normalize human body microbiocenosis, among them, after severe infections, antibiotics treatment and others. EFFECT: valuable medicinal properties of composition. 10 cl, 1 tbl
BACKGROUND: Previous studies have highlighted the crucial role of macrophages in the post-acute myocardial infarction (AMI) inflammatory response. This study specifically focused on investigating macrophage-related targets involved in the inflammatory response after AMI.
METHODS: Bioinformatics methods were applied for identifying differentially expressed genes (DEGs) in datasets GSE163465, GSE236374, and GSE183272 obtained from the Gene Expression Omnibus (GEO) database. Communication analysis was conducted to analyze macrophages in AMI. Subsequent analyses encompassed functional enrichment analysis of Co-DEGs using Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG). Gene set variation analysis (GSVA) and immune infiltration analysis were carried out for screening key genes. Validation of the bioinformatics analysis results involved original and GSE114695 datasets, supported by quantitative real time polymerase chain reaction (qRT-PCR). Animal experiments confirmed the upregulation of Saa3, Acp5, and Fcgr4 genes in AMI mouse myocardial tissues.
RESULTS: A total of 80 and 1,907 DEGs were respectively identified by analyzing scRNA-seq and bulk RNA-seq data. The overlapping Co-DEGs were found to be closely associated with inflammation-associated pathways, specifically the PI3K-Akt-mTOR pathway. Screening based on GSVA scores and macrophage-associated scores highlighted four key genes (Saa3, Ms4a4c, Acp5, and Fcgr4). Immunoinfiltration analysis revealed their close association with macrophages. Dataset validation corroborated these findings. Experimental validation focused on Saa3, Ms4a4c, Acp5, and Fcgr4, demonstrating the upregulation of their expression in cardiac macrophages in the AMI group, consistent with previous reports.
CONCLUSION: This study provides new perspectives on AMI treatment. In addition, Saa3, Acp5, and Fcgr4 exhibit potential as biomarkers for improving cardiac repair and slowing down the development of heart failure after AMI.
Chronic pancreatitis (CP) is a progressive inflammatory disease with an increasing global prevalence. In recent years, a strong association between CP and metabolic bone diseases (MBDs), especially osteoporosis, has been identified, attracting significant attention in the research field. Epidemiological data suggest a rising trend in the incidence of MBDs among CP patients. Notably, recent studies have highlighted a profound interplay between CP and altered nutritional and immune profiles, offering insights into its linkage with MBDs. At the molecular level, CP introduces a series of biochemical disturbances that compromise bone homeostasis. One critical observation is the disrupted metabolism of vitamin D and vitamin K, both essential micronutrients for maintaining bone integrity, in CP patients. In this review, we provide physio-pathological perspectives on the development and mechanisms of CP-related MBDs. We also outline some of the latest therapeutic strategies for treating patients with CP-associated MBDs, including stem cell transplantation, monoclonal antibodies, and probiotic therapy. In summary, CP-associated MBDs represent a rising medical challenge, involving multiple tissues and organs, complex disease mechanisms, and diverse treatment approaches. More in-depth studies are required to understand the complex interplay between CP and MBDs to facilitate the development of more specific and effective therapeutic approaches.
A conditioning chemotherapy regimen of fludarabine and cyclophosphamide will be administered followed by investigational treatment, CAR-T cells. CAR-T cells targeted CD19/BCMA/CD123/CD7 are autologous genetically modified T cells.
PURPOSE: Cisplatin-based chemoradiotherapy (CRT) is standard treatment for head and neck squamous cell carcinoma (HNSCC). However, IMRT may increase chemotherapy-induced nausea and vomiting (CINV). The purpose of this study is to investigate the effect of fosaprepitant in preventing CINV.
METHODS: An infusion of 150 mg fosaprepitant was given through a 30 min. We assessed acute toxicity using CTCAE v.4 and the incidence of CINV using the FLIE questionnaire. The evaluation of CINV was done at the second and fifth weeks of CRT and 1 week after the end. The EORTC QLQ-HN 43 questionnaire was administered before treatment beginning (baseline), at second (T1) and fifth (T2) weeks. A dosimetric analysis was performed on dorsal nucleus of vagus (DVC) and area postrema (AP).
RESULTS: Between March and November 2020, 24 patients were enrolled. No correlation was found between nausea and DVC mean dose (p = 0.573), and AP mean dose (p = 0.869). Based on the FLIE questionnaire, patients reported a mean score of 30.5 for nausea and 30 for vomiting during week 2 and 29.8 for nausea and 29.2 for vomiting during week 5. After treatment ended, the mean scores were 27.4 for nausea and 27.7 for vomiting. All patients completed the EORTC QLQ-HN 43. Significantly higher scores at T2 assessment than baseline were observed.
CONCLUSIONS: The use of fosaprepitant in preventing CINV reduced incidence of moderate to severe nausea and vomiting. No correlation has been found between nausea and median dose to DVC and AP.
Participants received Placebo for upadacitinib administered orally once a day (QD) as tablets for 24 weeks during Period 1. Participants then received upadacitinib 22 mg administered orally once a day (QD) as tablets for 28 weeks during Period 2.
Nanoparticles produced by and isolated from a fungus of the genus  Arthrobotrys  are disclosed and can comprise at least about 1% by weight of a glycosaminoglycan. Also disclosed are fractions obtained from the nanoparticles. Methods of preparing and isolating these nanoparticles and fractions are also disclosed. The disclosed nanoparticles and fractions are suitable as carries in a variety of medical formulations. Thus, in a further aspect, the present disclosure relates to compositions comprising the disclosed nanoparticles and fractions with carriers, excipients, and/or therapeutic agents. Methods of treating subjects with these compositions are also disclosed.
The proposed prospective, randomized, controlled trial will investigate the effect of osteopathic manipulative treatment (OMT) on sacral base asymmetry as assessed by ultrasound. The study will be conducted between July 2016 - June 2017 with data collection planned for August and September 2016. Forty men and women ages 20 to 55 years with at least one or more episodes of LBP in the past two weeks will be recruited from the Kirksville area. Participants will be randomly assigned into two groups, control or OMT using a random number generator. Males and females will be randomized separately to ensure equal distribution into the two study groups. Demographics including sex, age, and body mass index (BMI) will be collected on all participants. All participants will complete a brief medical history questionnaire, receive an initial palpatory assessment of the sacral base asymmetry, and then an initial ultrasound evaluation of sacral base asymmetry. After the ultrasound assessment, the control group will wait in another room for approximately 30 minutes. Participants in the OMT group will receive OMT to address sacral base asymmetry after the initial ultrasound assessment. Following the treatment period for the OMT group, all participants will receive a second ultrasound assessment of sacral base asymmetry. The ultrasonographer will be blinded on whether the subject received an OMT or not. After the second ultrasound measurement, the participants in the control group will be offered an OMT treatment consistent with that of the OMT group.
Warning: for emergency use only when administered by properly trained personnel for oxygen deficiency and resuscitation. For all other medical applications Rx Only. Uninterrupted use of high concentrations of oxygen over a long duration without monitoring oxygen content of arterial blood may be harmful. Uninterrupted use of high concentrations of oxygen for more than 5 hours may be harmful. Do not attempt to use on patients who have stopped breathing, unless used in conjunction with resuscitative equipment.

DO NOT REMOVE THIS PRODUCT LABEL
Placebo treatment following the same schedule as Arm 1 (i.e. Hydroxychloroquine).
Patients receiving neuraxial treatment with morphine for pain relief often experience a distressing pruritus. Neuroinflammation-mediated plasticity of sensory synapses in the spinal cord is critical for the development of pain and itch. Caspase-6, as an intracellular cysteine protease, is capable of inducing central nociceptive sensitization through regulating synaptic transmission and plasticity. Given the tight interaction between protein kinase Mζ (PKMζ) and excitatory synaptic plasticity, this pre-clinical study investigates whether caspase-6 contributes to morphine-induced itch and chronic itch via PKMζ. Intrathecal morphine and contact dermatitis were used to cause pruritus in mice. Morphine antinociception, itch-induced scratching behaviors, spinal activity of caspase-6, and phosphorylation of PKMζ and ERK were examined. Caspase-6 inhibitor Z-VEID-FMK, exogenous caspase-6 and PKMζ inhibitor ZIP were utilized to reveal the mechanisms and prevention of itch. Herein, we report that morphine induces significant scratching behaviors, which is accompanied by an increase in spinal caspase-6 cleavage and PKMζ phosphorylation (but not expression). Intrathecal injection of Z-VEID-FMK drastically reduces morphine-induced scratch bouts and spinal phosphorylation of PKMζ, without abolishing morphine analgesia. Moreover, intrathecal strategies of ZIP dose-dependently reduce morphine-induced itch-like behaviors. Spinal phosphorylation of ERK following neuraxial morphine is down-regulated by ZIP therapy. Recombinant caspase-6 directly exhibits scratching behaviors and spinal phosphorylation of ERK, which is compensated by PKMζ inhibition. Also, spinal inhibition of caspase-6 and PKMζ reduces the generation and maintenance of dermatitis-induced chronic itch. Together, these findings demonstrate that spinal caspase-6 modulation of PKMζ phosphorylation is important in the development of morphine-induced itch and dermatitis-induced itch in mice.
PURPOSE: During the COVID-19 pandemic, home-based and remote learning-particularly using electronic devices-was rapidly pushed out. Increased near-work, screen time exposure and lack of outdoor time are risk factors that contribute to childhood myopia, but it is difficult to adopt recommendations from prior publications as a consistent limitation in the literature is the heterogeneity of research methodology. This review seeks to systematically evaluate how observational studies published during the pandemic have quantified and measured risk factors and myopia in school-going children and adolescents.
METHODS: Three scientific databases (PubMed, CINAHL, Scopus) were systematically searched from March 2020 to April 2022. Findings from relevant studies were descriptively summarised in relation to the PICOS-based objective of the review.
RESULTS: The final sample of 13 studies included research from six countries and comprised 1 411 908 children and adolescents. The majority of studies (N = 10; 76.9%) used spherical equivalent refraction (SER) of -0.5 dioptres or lower as a common definition of myopia. Most studies (77.8%) measuring screen time exposure found it higher during COVID-19 compared to pre-COVID, but only one study used objective measurement of screen time. The average critical appraisal score of the sample was only 66.1%, with a considerable number of studies failing to identify and adjust for potential confounders.
CONCLUSION: Future studies should consider emergent objective and validated measures of risk factors, account for potential a priori confounders and covariates and ensure more representativeness in the sociodemographic makeup of their samples.
PURPOSE: To obtain a lip stick with reproducible hardness by completely esterifying fatty acids in a wax to be used, mixing an aluminum salt as a coloring agent into the wax, and forming the mixture into a colored stick-type cosmetic product. CONSTITUTION: A wax such as candelilla wax, carnauba wax, beewax, lanolin and spermaceti wax or a mixture of them is made to react with an alcohol (preferably 1 to 60C alcohol) to convert 12 to 60C fatty acids in the wax to respective esters. Then a coloring agent comprising an aluminum salt is mixed with the wax by about 0.001 to 20% (especially Red-3 aluminum lake. Red-21 aluminum lake and Blue-1 aluminum lake are preferable). Then the mixture is formed into a stick. Thus, the obtd. colored stick cosmetic product has improved rigidity for use. The wax is preferably included by 10 to 50 wt.% in the mixture. This method is economical, and yellow and red coloring agents having a good chromatic effect can be used for the product while keeping structural and visual completeness.
Unreduced megagametophytes via second-division restitution were confirmed through heterozygosity analysis, and four candidate physical centromeres of rubber were located for the first time. The evaluation of maternal heterozygosity restitution (MHR) is vital in identifying the mechanism of 2n gametogenesis and assessing the utilization value of 2n gametes. In this study, three full-sib triploid populations were employed to evaluate the MHR of 2n female gametes of rubber tree clone GT1 and to confirm their genetic derivation. The 2n female gametes of GT1 were derived from second-division restitution (SDR) and transmitted more than half of the parental heterozygosity. In addition, low recombination frequency markers were developed, and four candidate physical centromeres of rubber tree were located for the first time. The confirmation that 2n female gametes of rubber tree clone GT1 are derived from SDR provides insights into the molecular mechanisms of 2n gametogenesis. In addition, the identified centromere location will aid in the development of centromeric markers for the rapid identification of the 2n gametogenesis mechanism.
The global spread of the Omicron variant strain BA.5/BF.7 has led to an increase in breakthrough infections. The elderly population shows different immune responses after infection due to the aging of the immune system, which has not been fully studied. The aim of this study was to investigate the effect of aging on immune response after breakthrough infection of Omicron BA.5/BF.7 variant, especially the changes of protein immune mechanism. The study analyzed the concentration of antibodies in serum and their ability to neutralize the mutant strain by comparing the immune response of the elderly population and the young population after infection. Proteomics techniques were used to assess differences in the expression of key proteins in immune cells of different age groups. The study found that older subjects produced lower levels of antibodies after infection than younger subjects and showed a significantly reduced ability to neutralize against BA.5/BF.7. In addition, proteomic analysis showed that the expression of proteins related to inflammation and apoptosis significantly increased in the immune cells of the elderly, while the proteins related to antiviral response and cell repair significantly decreased. These findings provide new ideas for immune intervention strategies in the elderly population, and emphasize the targeted research of anti-virus vaccines.
The effectiveness of LAMICTAL XR as monotherapy for partial-onset seizures was established in a historical control trial in 223 adults with partial-onset seizures. The historical control methodology is described in a publication by French, et al. [see References (15)]. Briefly, in this study, patients were randomized to ultimately receive either LAMICTAL XR 300 or 250 mg once a day, and their responses were compared with those of a historical control group. The historical control consisted of a pooled analysis of the control groups from 8 studies of similar design, which utilized a subtherapeutic dose of an AED as a comparator. Statistical superiority to the historical control was considered to be demonstrated if the upper 95% confidence interval for the proportion of patients meeting escape criteria in patients receiving LAMICTAL XR remained below the lower 95% prediction interval of 65.3% derived from the historical control data.

In this study, patients aged 13 years and older experienced at least 4 partial-onset seizures during an 8-week baseline period with at least 1 seizure occurring during each of 2 consecutive 4-week periods while receiving valproate or a non–enzyme-inducing AED. LAMICTAL XR was added to either valproate or a non–enzyme-inducing AED over a 6- to 7-week period followed by the gradual withdrawal of the background AED. Patients were then continued on monotherapy with LAMICTAL XR for 12 weeks. The escape criteria were 1 or more of the following: (1) doubling of average monthly seizure count during any 28 consecutive days, (2) doubling of highest consecutive 2-day seizure frequency during the entire treatment phase, (3) emergence of a new seizure type compared with baseline (4) clinically significant prolongation of generalized tonic-clonic seizures or worsening of seizure considered by the investigator to require intervention. These criteria were similar to those in the 8 controlled trials from which the historical control group was constituted.

The upper 95% confidence limits of the proportion of subjects meeting escape criteria (40.2% at 300 mg/day and 44.5% at 250 mg/day) were below the threshold of 65.3% derived from the historical control data.

Although the study population was not fully comparable with the historical control population and the study was not fully blinded, numerous sensitivity analyses supported the primary results. Efficacy was further supported by the established effectiveness of the immediate-release formulation as monotherapy.
The invention discloses new application of Chukrasone B in preventing and treating osteoporosis. Osteoporosis is one of important diseases jeopardizing human health; and as the aging of population, osteoporotic patients increase progressively and bring about huge social, medical and economic burdens. Although related specialists and scholars at home and abroad attach great importance to osteoporosis, no effective therapeutic medicine can treat the disease. The in-vivo test detects that the Chukrasone B has obvious effect on resisting osteoporosis. The experimental result indicates that the Chukrasone B can inhibit the bone conversion rate enhancement caused by ovariectomy and cause less destruction of bones, and can also enhance the blood calcium concentration, thereby being beneficial to bone deposition. The Chukrasone B has therapeutic action on osteoporosis caused by estrogen deficiency, and does not have estrogen-like side effect.
PURPOSE: To obtain a medicinal agent with release of the active substance uniformly delayed overall in high reproducibility by bringing a medicinal agent comprising a compression-molded matrix composed of the powdery active substance and an auxiliary into contact with lower alcohol vapor. CONSTITUTION: A compression-molded mixture as solid matrix composed of a powdery active substance and a powdery acrylic ester polymer or vinyl ester polymer as auxiliary insoluble to the body fluid [at least gastric juice (pref. plus intestinal juice)] existing at a site to be applied to, is exposed to a vapor phase consisting of a lower alcohol, pref. a 2-4C alcohol, esp, ethanol to obtain the objective medicinal agent with release of the active substance uniformly delayed. The acrylic ester polymer is pref. a homopolymer or copolymer made from >=3wt.% of a (meth)acrylic 1-8C(pref. 1-4C)alkyl ester and <=70wt.% of an α,β-ethylenically unsaturated comonomer copolymerizable therewith.
BACKGROUND: No-reflow (NR) is characterized by an acute reduction in coronary flow that is not accompanied by coronary spasm, thrombosis, or dissection. Inflammatory prognostic index (IPI) is a novel marker that was reported to have a prognostic role in cancer patients and is calculated by neutrophil/lymphocyte ratio (NLR) multiplied by C-reactive protein/albumin ratio.
OBJECTIVE: We aimed to investigate the relationship between IPI and NR in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI).
METHODS: A total of 1541 patients were enrolled in this study (178 with NR and 1363 with reflow). Lasso panelized shrinkage was used for variable selection. A nomogram was created based on IPI for detecting the risk of NR development. Internal validation with Bootstrap resampling was used for model reproducibility. A two-sided p-value <0.05 was accepted as a significance level for statistical analyses.
RESULTS: IPI was higher in patients with NR than in patients with reflow. IPI was non-linearly associated with NR. IPI had a higher discriminative ability than the systemic immune-inflammation index, NLR, and CRP/albumin ratio. Adding IPI to the baseline multivariable logistic regression model improved the discrimination and net-clinical benefit effect of the model for detecting NR patients, and IPI was the most prominent variable in the full model. A nomogram was created based on IPI to predict the risk of NR. Bootstrap internal validation of nomogram showed a good calibration and discrimination ability.
CONCLUSION: This is the first study that shows the association of IPI with NR in STEMI patients who undergo pPCI.
PURPOSE:To obtain the titled cosmetic containing a pigment or extender pigment wherein hydrate titanium oxide is attached on the carrier surface as an active ingredient, having excellent ultraviolet ray-shielding effect, transparent feeling, good dispersibility as well as good extension to skin and smooth feel. CONSTITUTION:Hydrate titanium oxide is attached on the carrier surface. The objective cosmetic is prepared as follows. A extender pigment such as talc, kaolin, mica, etc., beads such as oxysalt of bismuth, acryl, etc., pigment such as yellow iron oxide, ultramarine blue, etc., is used as a carrier. A solution of hydrate titanium oxide sol to which as necessary a fixing agent such as a water soluble high polymer, e.g. polyvinylalcohol, etc., stabilizer, water, and the like is added to the carrier, uniformly mixed and dried. As the drying method, a spray dryer, etc., is preferably used. Then, as necessary, surface- treatment is carried out using a surface-treating agent. The titanium oxide sol is added preferably in a range of 0.05-10% based on the carrier.