anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To provide a skin coloring agent for giving a color which resemble naturally suntanned color and last over a long term. CONSTITUTION: The skin coloring agent is prepd. by incorporating a hydroxycarbonyl compd. having a natural sunburn characteristic, more preferably dihydroxyacetone and methylglyoxal into a cosmetologically permissible carrier and incorporating at least one kind of coloring agents sticking to the skin, more preferably red coloring agents, more particularly eosine G and erythrosine I therein. The skin coloring compds. are preferably incorporated at 0.1 to 10% (weight), more particularly 1 to 6% and the coloring agents at 0.01 to 0.1%, more particularly 0.05% into this agent. Any selected from water, a mixture composed of the water and >=1 kinds of org. solvents, fates and a mixture composed of >=1 kinds of the org. solvents are used as the carrier described above. A UV filter for protection of UV-A and/or UV-B light is preferably incorporated into this agent.
The enrolled individuals with HCC would receive serum DNA methylation test before their treatment (including all kinds of recommened HCC treatment). Then regularly serum DNA methylation test would be done at 4th\~8th weeks, 16th week, 32th week and 48th week. If the enrolled patients did not have HCC recurrence during at 48th week. The regular check of serum DNA methylation would be canceled. The enrolled patients would be observed till 96th week. If there is any recurrence during 48\~96th week, one time of serum DNA methylation would be checked at the time of recurrence. The observation and intervention would be completed at 96th week.
PURPOSE:To remedy and preventive for ulcers of digestive organs, having protecting action on mucous cell of stomach with a small amount of administration without causing inhibition of secretion of acid in the stomach, containing a specific compound extracted and separated from a water-soluble fraction derived from cinnamon or its derivative as an active ingredient. CONSTITUTION:A remedy and preventive for ulcers of digestive organs containing at least one compound selected from a compound shown by the formula I(R is H or organic residue) extracted and separated from a water-soluble fraction derived from cinnamon, its nontoxic salt and a compound shown by the formula II as an active ingredient. The compounds shown by the formulas I and II are effective against wide ulcer model (e.g., stress ulcer, serotonin ulcer, etc.) with 10-200mug/kg/day. The remedy and preventive develops antiulcer activity with a small amount hardly to develop inhibition of secretion of acid in the stomach. Especially it has protecting action on mucous cell of stomach and is effective for damage of the mucosa caused with ethanol.
Health-related quality of life (HRQOL) is a patient-reported outcome that assesses the impact of a disease or illness on different domains of a patient's life. Different general and disease-specific measures can be used to evaluate HRQOL. This article aimed to summarize the evidence for HRQOL among patients with transfusion-dependent (TDT) and non-transfusion-dependent thalassemia (NTDT). We included HRQOL data related to standard therapy with blood transfusions, iron chelation, and/or luspatercept in TDT and NTDT, as well as curative therapies for TDT, including hematopoietic stem cell transplant (HSCT) and gene therapy. Patients with thalassemia had worse HRQOL scores compared to the general population, and chronic pain was seen to increase in frequency and severity over time with age. NTDT patients reported worse physical health and functioning, mental health, general health, and vitality than TDT patients. However, TDT patients reported worse pain, change in health, and social support than NTDT. Most therapies improved overall HRQOL among thalassemia patients. Deferasirox, an oral iron chelator, was associated with more HRQOL benefits compared to deferoxamine, an intravenous iron chelator. Luspatercept showed clinically meaningful improvement in physical functioning among TDT and NTDT. Furthermore, HSCT and gene therapy were associated with better physical, emotional, and mental domains scores.
Demands from society on stroke patients of younger age are in most cases higher than for elderly stroke patients, because of occupational obligations and often their role as a caregiver for a young family. For example, return to their former workplace may be impossible even if cognitive deficits, e.g., in the memory domain, are only "minor" according to standardized tests. Thus, cognitive function after stroke is of utmost importance for activities of daily life and quality of life in young stroke patients. In order to prevent or at least reduce post-stroke cognitive decline, the mechanisms underlying the decline need to be further elucidated, to eventually develop new preventive and therapeutic approaches.

T-cell activation is associated with destruction of brain tissue. In neurodegenerative diseases that primarily impair cognitive functions, e. g., Alzheimers Disease, T-cells were identified as important mediators of disease pathology. Activation of cells of the adaptive immune system, most importantly T-cells, has been also investigated in experimental stroke. Here, these cells significantly contribute to secondary brain tissue damage. Stroke is associated with massive changes of the central and peripheral immune response. The investigators and other groups demonstrated that despite an overall lymphopenia, T-cells are functionally intact and pro-inflammatorily polarized, for at least two weeks post-stroke. Depletion of T cells has been shown to reduce infarct volume and to improve outcome in mice post-experimental stroke.
Overactive bladder is a common problem that follows chronic prostatic bladder outlet obstruction and is part of the benign prostatic hyperplasia syndrome (BPH) in men. Unfortunately, it does not often resolve after treatment (TURP, etc) of the obstruction from enlarged prostate gland. Patients with obstructive BPH typically commence treatment with alpha-blockers or anticholinergic agents; the former being used to treat enlarged prostate medically, and the latter to treat overactive bladder symptoms. However, as mentioned, anticholinergics cause many intolerable side effects leading to discontinuation in many patients. Furthermore this class of drug is still considered a relative contraindication in this population by some clinicians. Therefore other modalities need to be studied in these men.

Based on numerous studies in overactive bladder (OAB), we hypothesize that these patients will experience significant improvement (particularly if their symptoms of urgency and frequency) without significant side effects from intradetrusor injections of BOTOX® even though they have were refractory to systemic anticholinergics.
Tri-Circulator (TC) is a product comprising coenzyme Q10 (CoQ10), Salvia miltiorrhiza, and Panax notoginseng. Individually, each of these constituents has demonstrated protective effects on myocardial injury. The purpose of this study is to evaluate the protective efficacy of TC on heart function and compare the differential effects between CoQ10 and TC. Two myocardial injury models of zebrafish, the hypoxia-reoxygenation model (H/R) and the isoproterenol (ISO, a β-receptor agonist) model, were used in this experiment. The zebrafish subjects were divided into 4 groups: control, H/R, TC, and CoQ10. Heart rate, stroke volume (SV), cardiac output (CO), ejection fraction (EF), fractional area change (FAC), and pericardial height were monitored to assess changes in heart function. The gene expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) was studied as markers of injury/stress. TC significantly suppresses elevated heart rate induced by H/R and prevents the decrease of heart rate induced by ISO. It alleviates the pericardial infusion induced by ISO, whereas CoQ10 does not possess a similar effect. Both TC and CoQ10 significantly inhibit the decline in SV, CO, EF, and FAC induced by H/R and ISO, and suppress the expression of ANP and BNP in cardiomyocytes induced by ISO. It is noteworthy that TC demonstrates a more pronounced effect on EF, FAC, ANP, and BNP gene expression compared to CoQ10. Both TC and CoQ10 have a protective effect on myocardial injury of zebrafish. However, TC exhibits a greater efficacy compared to CoQ10 alone in mitigating myocardial injury.
INTRODUCTION: due to the inability of low-income populations to access nutritious foods or basic education, these groups usually consume unhealthy diets, which frequently lead to nutrition issues like obesity, malnutrition, and other health morbidities. The purpose of the study was to evaluate the nutritional knowledge, dietary practices, nutritional status, and factors influencing the dietary habits of low-income persons living in a rural constituency in Southern Nigeria.
METHODS: a cross-sectional study was carried out on 419 consenting low-income adults (18 years and older) using a simple random technique, in order to collect data on their socio-demographic traits, nutritional knowledge, dietary practices, and nutritional status. Statistical Package for Social Sciences (SPSS) version 22.0 was used to analyze the data generated.
RESULTS: the respondents´ the average age was 40.9 ± 15.68 years while 224 (53.5%) of those surveyed were females. The proportion of responders with a secondary education was highest 279 (66.6%). The most common occupation among respondents was farming 151 (36.1%) and petty trading 135 (32.2%). Overall, 314 (74.9%) of low-income adults had poor dietary habits, and 245 (60.6%) had poor nutrition knowledge. Occupation and gender were significantly associated with nutritional status P<0.05. The majority of respondents 56.2% (235) were overweight or obese, and multivariate logistic regression analysis shows that respondents with concern about gaining weight were more likely to be overweight or obese (OR=1.065, 95% CI=0.832-1.363).
CONCLUSION: the findings from the study indicate that inadequate nutritional knowledge and poor dietary habits, reflected in respondents' body weight are likely to increase the risk of non-communicable diseases, necessitating the need for nutritional education among rural populations.
CPI-naïve SCC of the head and neck (SCCHN) (20 response-evaluable participants), mandatory biopsies. Participants in cohort K Part III will receive simlukafusp alfa QW in combination with atezolizumab Q2W for 4 weeks followed by simlukafusp alfa in combination with atezolizumab Q2W. Simlukafusp alfa will be administered at a 10 mg flat dose. Atezolizumab IV infusion will be administered at a dose of 840 mg. Tumor biopsies: one mandatory fresh tumor biopsy will be collected at baseline. Additional on-treatment biopsies will be optional. Biopsies are not applicable to participants presenting with a single target lesion and absence of any non-target lesion.
Systems and methods for the validation and transform of data for processing by an algorithm is provided. Additionally, systems and methods for data obfuscation are provided. Data obfuscation is needed when protecting an algorithm from reverse engineering attempts. Other embodiments relate to systems and methods for validating algorithms across different parties' systems by generating synthetic data for operation on algorithms. The synthetic data may include real data that has been de-identified, data that had been altered by pseudo-random deviations (range and distribution bound), or via generation by a ML algorithm that has been trained on real datasets. In yet other embodiments, annotation validation can be performed. In some embodiments, it is possible to receive sensitive data from a plurality of data sources and combine such data before processing.
The invention belongs to the technical field of medicines, and discloses a first-aid spray for patients with myocardial infarction and cerebral infarction as well as a preparation method and application thereof. According to the traditional Chinese medicine, the myocardial infarction belongs to the syndrome of qi stagnation and blood stasis and is caused by congealing cold in the heart pulse to cause heart-yang collapse. The disease can be relieved by using a medicine formula which can promote blood circulation to remove blood stasis, dispel cold to remove arthralgia, dredge collaterals to relieve pain and restore yang to rescue collapse. The first-aid spray is prepared from camphor: pungent-heat enters heart meridian. Dispelling cold, relieving pain, inducing resuscitation and refreshing brain; cassia twig: the sexual warmth enters heart, lung and bladder meridians, relieves muscles, warms meridians and helps yang and regulate qi. Ginseng: the sexual warm property is good for the channels of heart, lung, spleen and kidney, and can tonify primordial qi, strengthen heart, remove blood stasis, induce tranquilization, restore yang and relieve depletion. Ligusticum wallichii: the pungent and warm natured herbs enter the pericardium meridian of liver and gallbladder to promote the circulation of qi and relieve depression. The curative effect of the traditional Chinese medicine can be doubled by soaking the traditional Chinese medicine in 30-degree white spirit. The white spirit has strong penetrating power and strong alcohol pungency, can stimulate skin to generate a series of stress reactions, can promote the absorption and utilization of blood vessels to medicaments, and can also activate blood circulation to dissipate blood stasis, refresh mind and restore yang.
The invention discloses wine ganoderma pollen anti-aging cream and a manufacture method thereof. The cream comprises the following components, by mass part, 30-50 parts of ganoderma pollen, 3-5 parts of stearic acid, 6-8 parts of higher alcohol, 6-10 parts of glycerin, 10-12 parts of a tuber fleeceflower stem extract, 10-12 parts of lanolin, 5-7 parts of distilled glycerol monostearate, 5-15 parts of ethanol, 13-15 parts of corn oil, 6-10 parts of a pollen cold extract, 6-8 parts of a lactuca formosana extract, 20-30 parts of rape pollen and 6-8 parts of a bezoar extract. The cream can replenish the body with natural elements, improve elemental balance in the body, and improve the disease resistance of the human body and the cell activity. The cream can treat internal diseases through external treatment. The cream can effectively clean free radicals in the body, filter and absorb poison, resist heavy metal, prevent cancer and resist radiation. The cream can beautify and protect the skin, resist aging, and keep the skin vigorous and graceful for a long time.
To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.
Without intervention, a considerable proportion of patients with metabolism-associated fatty liver disease (MAFLD) will progress from simple steatosis to metabolism-associated steatohepatitis (MASH), liver fibrosis, and even hepatocellular carcinoma. However, the molecular mechanisms that control progressive MAFLD have yet to be fully determined. Here, we unraveled that the expression of the N6-methyladenosine (m6A) methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD, whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation, liver injury, and fibrosis. Conversely, hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet (HFD). Notably, in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner, which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1+Ccr2+ monocyte-derived macrophages (Mo-macs). In detail, Cx3cr1+Ccr2+ Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells (HSCs) to promote liver fibrosis. Further experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1+Ccr2+ Mo-macs. Restoration of METTL14 or GLS2, or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and fibrosis. Taken together, these findings indicate potential therapies for the treatment of MAFLD progression.
Beginning 7-14 days prior to start of pembrolizumab, nivolumab, or atezolizumab, patients receive nelfinavir mesylate PO BID on days 1-7 or 1-14 (dependent upon when treatment is started) up to 11-12 weeks. Patients also receive pembrolizumab, nivolumab or atezolizumab IV over 30-60 minutes on day 1. Cycles repeat every 21-28 days in the absence of disease progression or unacceptable toxicity. Patients then undergo hypofractionated radiation therapy over 3-14 days starting after cycle 1 and before cycle 3 of pembrolizumab, nivolumab or atezolizumab. The study will exclude irradiation of liver metastases as an added precaution.
Neuroinflammation is a major driver of postoperative cognitive dysfunction (POCD). The cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) signaling is a prominent alarming device for aberrant double-stranded DNA (dsDNA) that has emerged as a key mediator of neuroinflammation in cognitive-related diseases. However, the role of the cGAS-STING pathway in the pathogenesis of POCD remains unclear. A POCD model was developed in male C57BL/6J mice by laparotomy under isoflurane (Iso) anesthesia. The cGAS inhibitor RU.521 and caspase-3 agonist Raptinal were delivered by intraperitoneal administration. BV2 cells were exposed to Iso and lipopolysaccharide (LPS) in the absence or presence of RU.521, and then cocultured with HT22 cells in the absence or presence of Raptinal. Cognitive function was assessed using the Morris water maze test and novel object recognition test. Immunofluorescence assays were used to observe the colocalization of dsDNA and cGAS. The downstream proteins and pro-inflammatory cytokines were detected using the Western blot and enzyme-linked immunosorbent assay (ELISA). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was used to assess the degree of cell death in the hippocampus following anesthesia/surgery treatment. Isoflurane/laparotomy and Iso + LPS significantly augmented the levels of cGAS in the hippocampus and BV2 cells, accompanied by mislocalized dsDNA accumulation in the cytoplasm. RU.521 alleviated cognitive impairment, diminished the levels of 2'3'-cGAMP, cGAS, STING, phosphorylated NF-κB p65 and NF-κB-pertinent pro-inflammatory cytokines (TNFα and IL-6), and repressed pyroptosis-associated elements containing cleaved caspase-3, N-GSDME, IL-1β and IL-18. These phenotypes could be rescued by Raptinal in vivo and in vitro. These findings suggest that pharmacological inhibition of cGAS mitigates neuroinflammatory burden of POCD by dampening caspase-3/GSDME-dependent pyroptosis, providing a potential therapeutic strategy for POCD.
Group 1 consists of 20 RP patients (40 eyes) who received combined rEMS with PRP. In this group, patients received rEMS for 30 minutes before subtenon PRP injections. In this group, 3 loading doses were applied at 3-week intervals. Then 2 booster dose were applied at 6-month intervals.
a -6-Deoxytetracycline is prepared by contacting 6-deoxy-13-mercaptotetracycline, or an acid addition salt thereof, with at least an equivalent amount of tri- C1- 4 alkyl-phosphite in the presence of 0.1 to 1.0 parts by weight, based on the tetracycline, of a free-radical-generating catalyst at a temperature of 50-150 DEG C. and isolating the a -6-deoxytetracycline or an acid addition salt thereof from the reaction mixture. a -6-Deoxy-5-oxytetracycline is prepared from 6-deoxy-13-mercapto-5-oxytetracycline in a similar manner. The 13-mercaptotetracycline sulphosalicylate is a preferred salt anda ,a -azobis-isobutyronitrile is a preferred catalyst. Other catalysts are inorganic and organic peroxides, e.g. hydrogen peroxide, diethyl peroxide, t-butyl hydroperoxide, acetyl peroxide and coconut oil acid peroxide and other azo compounds, e.g. 1-azobis-(cyclohexancarbonitrile).
Glycogen-storing so-called clear cell kidney tubules (CCTs), precursor lesions of renal cell carcinoma, have been described in diabetic rats and in humans. The lesions show upregulation of the Akt/mTOR-pathway and the related transcription factor carbohydrate responsive element binding protein (ChREBP), which is supposedly pro-oncogenic. We investigated the effect of ChREBP-knockout on nephrocarcinogenesis in streptozotocin-induced diabetic and normoglycemic mice. Diabetic, but not non-diabetic mice, showed CCTs at 3, 6 and 12 months of age. Glycogenosis was confirmed by periodic acid schiff reaction and transmission electron microscopy. CCTs in ChREBP-knockout mice consisted of larger cells and occurred more frequently compared to wildtype mice. Progression towards kidney tumors was observed in both diabetic groups but occurred earlier in ChREBP-knockout mice. Proliferative activity assessed by BrdU-labeling was lower in 1-week-old but higher in 12-month-old diabetic ChREBP-knockout mice. Surprisingly, renal neoplasms occurred spontaneously in non-diabetic ChREBP-knockout, but not non-diabetic wildtype mice, indicating an unexpected tumor-suppressive function of ChREBP. Immunohistochemistry showed upregulated glycolysis and lipogenesis, along with activated Akt/mTOR-signaling in tumors of ChREBP-knockout groups. Immunohistochemistry of human clear cell renal cell carcinomas revealed reduced ChREBP expression compared to normal kidney tissue. However, the molecular mechanisms by which loss of ChREBP might facilitate tumorigenesis require further investigation.
The invention discloses a preparation technology of an oral vaccine for resisting salmonella. The preparation technology comprises the following steps of constructing escherichia coli for expressing antigens of salmonella SEF14 and SEF21 fimbriaes, carrying out fimbrial antigen purification by a protein purification technology, dissolving dipalmitoyl phosphatidyl choline, dipalmitoyl phosphatidylserine and cholesterol in an organic solvent, fully mixing, drying mixed lipid, adding a certain amount of the antigens of SEF14 and SEF21 into a mixed lipid membrane, fully mixing, and carrying out lipid membrane vortex-type dispersion to obtain the oral vaccine. The preparation technology greatly improves the purity of salmonella antigens, and realizes stable, simple and controllable production having a high yield and high purity. The oral vaccine obtained by the preparation technology has effects of effectively resisting an acid environment and a damage caused by a body enzyme system. Through the preparation technology, SEF14 and SEF21 fimbriae protein antigens can be applied by an oral method. The preparation technology realizes complete detoxification and high immunogenicity and does not produce environmental pollution.