anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: As an emerging infectious disease with a heterogenous and uncertain transmission pattern, coronavirus disease 2019 (COVID-19) has created a catastrophe in healthcare-associated infections (HAIs) and posed a significant challenge to infection control practices (ICPs) in healthcare settings. While the unique characteristics of psychiatric patients and clinical settings may make the implementation of ICPs difficult, evidence is lacking for compliance with ICPs among healthcare workers (HCWs) in a psychiatric setting during the COVID-19 pandemic.
METHODS: A cross-sectional multi-method study based on participant unobtrusive observation coupled with the completion of a self-administered ICP survey was conducted to assess compliance with ICPs among HCWs in a psychiatric inpatient ward in a regional hospital. An online checklist, called eRub, was used to record the performance of HCWs in hand hygiene (HH) and other essential ICPs. Furthermore, a well-validated questionnaire (i.e., Compliance with Standard Precautions Scale, CSPS) was used to collect the participants' self-reported ICP compliance for later comparison.
RESULTS: A total of 2,670 ICP opportunities were observed from January to April 2020. The overall compliance rate was 42.6%. HCWs exhibited satisfactory compliance to the wearing of mask (91.2%) and the handling of clinical waste (87.5%); suboptimal compliance to the handling of sharp objects (67.7%) and linen (72.7%); and poor compliance to HH (3.3%), use of gloves (40.9%), use of personal protective equipment (20%), and disinfection of used surface/area (0.4%). The compliance rates of the nurses and support staff to HH were significantly different (χ2 = 123.25, p < 0.001). In the self-reported survey, the overall compliance rate for ICPs was 64.6%.
CONCLUSION: The compliance of HCWs in a psychiatric inpatient ward to ICPs during the COVID-19 pandemic ranged from poor to suboptimal. This result was alarming. Revisions of current ICP guidelines and policies that specifically target barriers in psychiatric settings will be necessary.
Maxillary expansion was performed for adult female patients suffering from maxillary constriction with bilateral posterior cross-bite \& dental arch discrepancy average 12 mm using fixed Quad-helix appliance, for about 8 months. The appliance was delivered and activated at the day of corticotomy and bone graft (demineralized freeze-dried bone allograft). The activation was made half-molar unit each side. The patient was scheduled each month to activate the appliance or reactivate if needed. Corticotomy was performed at area of maxillary 1st premolar, 2nd premolar and first molar. Cone beam computed tomography was performed at three stages.

T1 (baseline) Before appliance activation and corticotomy. T2 At the end of expansion. (about 8 months of expansion). T3 At the finishing stage of orthodontic treatment (average 2.5 years from start of treatment).
PCT No. PCT/GB95/03039 Sec. 371 Date Dec. 3, 1996 Sec. 102(e) Date Dec. 3, 1996 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/20199 PCT Pub. Date Jul. 4, 1996A di-clavulanate salt derived from clavulanic acid and a diamino ether of the formula   <IMAGE>   wherein R1 is an alkylene group, optionally having one or more inert substituents: and each of R2 and R3 is a hydrogen atom or an alkyl group, optionally having one or more inert substituents, or R2 and R3 together complete a heterocyclic ring having four to seven carbon atoms, again optionally having one or more inert substituents. A process for preparing the clavulanic acid salt includes the steps of preparing a substantially water free solution of clavulanic acid, or a salt thereof, in an organic solvent which solution is at a maintained temperature of 0 DEG  to 15 DEG  C. and then reacting the clavulanic acid, or salt thereof, with diamino ether in the organic solvent.
The invention provides a bovine viral diarrhea virus BVDV-BJ175170 and application thereof. The preservation number of BVDV-BJ175170 is CGMCC NO. 18339. Expression of E thereof by cloning rns The protein is used for ELISA detection of BVDV and preparation of a kit. The kit is convenient to operate,The kit has low cost and good repeatability, can detect the viral diarrhea virus antibody with the serum dilution of 1:6400, makes up the defect that the BVDV-PI cattle is diagnosed by lacking single antigen at present, has higher sensitivity, reduces the omission factor, has higher precision, and can be used for monitoring the antibody level. The method combines the high specificity reaction of antigen and antibody, and can more accurately detect E in the serum rns The protein antibody provides a sensitive detection means for the epidemiological investigation of BVDV in China, and can be used for early diagnosis of bovine viral diarrhea virus infection.
1. Technical Result Increase in efficiency of treatment of proliferative diseases.         2. Essence A compounds of formula (I),    wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of proliferative diseases such as cancer.         3. Field of Application Medicine.
During the anesthesia outpatient consultation, patients proposed for minor abdominal surgery, known hypertensive patients are selected. If the blood pressure figures are balanced in the previous 12 months, they are included in the study and the anesthesiologist informs them of the study protocol and obtains their consent.

On the day of the procedure, the patient is admitted to the operating room. We begin warming the patient and carry out standard monitoring, then, we check the blood pressure figures. If the numbers are high: SBP ≥ 180 and/or PAD≥110: we start by a filling as well as a dose of 1 mg Midazolam IV and the blood pressure figures are re-evaluated. If 3 measurements blood pressure figures remain above the threshold values: Surgery is postponed and the patient will be included to group (A) for canceled. If the blood pressure figures are correct, the surgery is accepted and the patient will be included in the group (NA) for not canceled.
The invention discloses traditional Chinese medicine for treating allergic skin disease and a preparing method thereof. The traditional Chinese medicine comprises a first composition and a second composition. The first composition is prepared from, by weight, 40-60 parts of radix sophorae flavescentis, 10-12 parts of cortex phellodendri, 5-6 parts of rhizoma coptidis, 8-10 parts of rhizoma atractylodis macrocephalae, 8-10 parts of radix ophiopogonis, 5-6 parts of fructus cnidii, 8-10 parts of elaeagnus angustifolia, 10-15 parts of codonopsis pilosula, 2 parts of inula britannica, 2 parts of flos pyrethri tatsienensis and 5 parts of lac; the second composition is prepared from, by weight, 50 parts of straw ash, 10-12 parts of longhairy antenoron herb ash and 2 parts of tobacco stick ash. The traditional Chinese medicine for treating allergic skin disease has an exact effect of treating the allergic skin disease, and the healing efficiency is high; in addition, the symptoms of some patients can be improved. The invention further discloses a preparing method for the traditional Chinese medicine. The preparing method is simple.
FIELD: medicine, dermatology. SUBSTANCE: invention relates to a composition used for skin care containing saturated hydroxyacid amide in combination with retinol or retinyl ester that results to synergistic inhibition of differentiation of keratinocytes. This effect is similar with that of retinoic acid. Invention relates to also a method of mimicking effect of retinoic acid on skin and method of skin care. EFFECT: enhanced effectiveness of composition, improved method of care and mimicking. 5 cl, 3 tbl, 8 ex
A dentifrice comprises an inorganic water-soluble fluoride capable of retarding caries, an insoluble alkali-metal metaphosphate abrasive, and a sacrificial metal ion-free dentifrice vehicle, the dentifrice being buffered at an acid pH which can be tolerated by oral tissues with either a phosphate buffer capable of adjusting pH to the acid side or an hydroxy carboxylate buffer, the latter being used when the water-soluble fluoride tends to form insoluble salts with the phosphate buffer. The water-soluble fluoride component may comprise HF in aqueous solution, or an alkali metal (e.g. Na, K or Li), ammonium, or transition metal (e.g. Mn or Sn) salt thereof. Insoluble Na, K or ammonium metaphosphates e.g. Maddrell's salts may be used as the abrasive, optionally with other non-calcium-containing abrasives e.g. Al2O3, TiO2, ground pumice, powered nylon, ground melamine-aldehyde resins, calcined aluminium silicate, and micro-crystalline cellulose.  The phosphate buffer may be H3PO4, or one of its alkali metal salts, ammonium salts, or salts of an organic base e.g. ethanolamine.  The salts may be in the mono-, di- or tri-basic forms.  Either aliphatic or aromatic mono- or poly-hydroxy carboxylic acids or salts thereof may be used.  Specified hydroxy carboxylates are sodium malate, malic acid, citric acid, tartaric acid, tartronic acid, and salicylic acid.  The dentifrice may also contain one or more surface active agents, flavouring agents, and sweeteners.  The dentifrice may be formulated as a toothpaste or toothpowder with conventional carriers, softeners, binders, and/or humectants.
BACKGROUND Bone cement displacement (BCD), which has received increasing attention from scholars, is a serious complication following vertebroplasty in patients with osteoporotic vertebral fractures (OVFs), and percutaneous kyphoplasty (PKP) might promote its occurrence. However, few studies have systematically explored the risk factors of BCD after PKP. This research aimed to study the risk factors for BCD following PKP. MATERIAL AND METHODS The clinical data of patients with OVFs treated with PKP from June 2016 to August 2022 in our department were retrospectively reviewed. Patients were categorized into the bone cement displacement group and the bone cement non-displacement group. Data on the subjects and their radiologic images were gathered for univariate analysis and binary logistic regression analysis. The receiver operating characteristic (ROC) curve and confusion matrix were utilized to assess the discrimination ability. RESULTS We included 181 patients, of which 12 had BCD after PKP. Binary logistic regression analysis revealed that independent risk factors associated with BCD after PKP were: high BMI, high restoration rate of the Cobb angle, high distance between the bone cement and the vertebral endplates, and presence of bone cement leakage. The ROC curve and confusion matrix indicates that logistic regression exhibited a strong predictive value for BCD. CONCLUSIONS Patients with a high BMI, a high restoration rate of the Cobb angle, a high distance between the bone cement and the vertebral endplates, and bone cement leakage have an increased risk of BCD after PKP.
The present invention discloses mole cricket fatty oil and a supercritical CO2 extracting method thereof. The extraction technology of the fatty oil comprises the following steps: a dry mole cricket is put in a supercritical extraction kettle after being pulverized, and then, CO2 in a supercritical state is continuously led into the extraction kettle to extract the dry mole cricket; the pressure of the CO2 which dissolves the fatty oil is reduced, the CO2 enters an analyzing kettle, and then, the CO2 is precipitated from the bottom of the analyzing kettle to obtain mole cricket fatty oil. The mole cricket fatty oil is in a light yellow transparent oil shape under the condition of room temperature; the extraction conditions are selected through the orthogonal design method with four factors and three levels; the purity of the total fatty acid in the mole cricket fatty oil which is extracted is from 60 to 95%, which is superior to other extracting methods. The present invention has the advantages of simple and convenient operation and high product purity; CO2 which has the advantages of low cost, easy acquisition, no toxicity and safety is used as an extraction agent, and can be circularly used; thus, the cost is greatly reduced, and the present invention is convenient to realize industrialization. In the process of extraction, no waste is discharged, no environmental pollution occurs, no harmful solvents remain, etc. The occupation ground area is small, the extraction efficiency is high, and energy sources are saved.
Low blood pressure (BP) is associated with poor outcomes in patients with heart failure (HF). We investigated the influence of initial BP on the prognosis of HF patients at admission, and prescribing patterns of HF medications, such as angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARB), and beta-blockers (BB). Data were sourced from a multicentre cohort of patients admitted for acute HF. Patients were grouped into heart failure reduced ejection fraction (HFrEF) and HF mildly reduced/preserved ejection fraction (HFmrEF/HFpEF) groups. Initial systolic and diastolic BPs were categorized into specific ranges. Among 2778 patients, those with HFrEF were prescribed ACEi, ARB, or BB at discharge, regardless of their initial BP. However, medication use in HFmrEF/HFpEF patients tended to decrease as BP decreased. Lower initial BP in HFrEF patients correlated with an increased incidence of all-cause death and composite clinical events, including HF readmission or all-cause death. However, no significant differences in clinical outcomes were observed in HFmrEF/HFpEF patients according to BP. Initial systolic (< 120 mmHg) and diastolic (< 80 mmHg) BPs were independently associated with a 1.81-fold (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.349-2.417, p < 0.001) and 2.24-fold (OR 2.24, 95% CI 1.645-3.053, p < 0.001) increased risk of long-term mortality in HFrEF patients, respectively. In conclusion, low initial BP in HFrEF patients correlated with adverse clinical outcomes, and BP < 120/80 mmHg independently increased mortality. However, this relationship was not observed in HFmrEF/HFpEF patients.
Background Endoscopic treatment of patients with chronic calcifying pancreatitis (CCP) is still challenging and controversially discussed. The goal is symptom control and relief of pain, which can be achieved by draining an obstructed main pancreatic duct (MPD) and/or removal of ductal stones. The 2012 European Society of Gastrointestinal Endoscopy (ESGE)- Guidelines recommends ESWL as a first step for patients with uncomplicated painful chronic pancreatitis and radiopaque stones ≥5mm obstructing the MPD. However, limitations of ESWL (extracorporeal shockwave lithotripsy ) include its limited availability, a likely need for multiple sessions and often repeated ERCP (endoscopic retrograde cholangiopancreatography) sessions for removal of stone fragments or treatment of associated strictures.

Pancreatoscopically guided management of pancreatic stones offers a potential alternative to ESWL. However, the numbers of studies and enrolled patients are still low. In 2015 single operator video cholangioscopy (SpyGlassDS, Boston Scientific) was introduced. Available data on its use for pancreatoscopy is limited. The technique provides digital imaging with a higher resolution and improved maneuverability compared to the legacy fiberoptic system. In addition, the working channel was enlarged to a diameter of 1.3 mm. Although SOVP have shown promise in CCP, studies to date generally have been limited by: retrospective design, relatively small and mixed patient populations, short follow-up periods, different clinical and technical endpoints, and, often, a single-center design. Therefore, the investigators designed a prospective multicenter cohort study to evaluate long-term clinical efficacy, technical success and safety of SOVP.
Biallelic mutation in the DNA-damage repair gene NBN is the genetic cause of Nijmegen breakage syndrome, which is associated with predisposition to lymphoid malignancies. Heterozygous carriers of germ line NBN variants may also be at risk for leukemia development, although this is much less characterized. By sequencing 4325 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL), we systematically examined the frequency of germ line NBN variants and identified 25 unique, putatively damaging NBN coding variants in 50 patients. Compared with the frequency of NBN variants in gnomAD noncancer controls (189 unique, putatively damaging NBN coding variants in 472 of 118 479 individuals), we found significant overrepresentation in pediatric B-ALL (P = .004; odds ratio, 1.8). Most B-ALL-risk variants were missense and cluster within the NBN N-terminal domains. Using 2 functional assays, we verified 14 of 25 variants with severe loss-of-function phenotypes and thus classified these as nonfunctional or partially functional. Finally, we found that germ line NBN variant carriers, all of whom were identified as heterozygous genotypes, showed similar survival outcomes relative to those with wild type status. Taken together, our findings provide novel insights into the genetic predisposition to B-ALL, and the impact of NBN variants on protein function and suggest that heterozygous NBN variant carriers may safely receive B-ALL therapy. These trials were registered at www.clinicaltrials.gov as #NCT01225874, NCT00075725, NCT00103285, NCI-T93-0101D, and NCT00137111.
FIELD: medicine, oncology. SUBSTANCE: method involves the use of interferon-regulating factor-1 (IRF-1) as a molecular marker. IRF-1-specific RNA is analyzed in blood sample or in another biomaterial using reverse transcription/polymerase chain reaction or content of biologically active polypeptide IRF-1 is determined in this sample. Unusual exon "skipping" leads to formation of RNA molecules that have lost exon 2 or exons 2 and 3. Relative amount of full length RNA and truncated molecules are distinct significantly in samples obtained from cancer patients and from health donors. Invention relates to IRF-1-specific oligonucleotides also. Method can be used for diagnosis of cancer, precancer state and predisposition to other forms of diseases. EFFECT: improved method of diagnosis.
Patients will receive a four probiotic preparation (LactoLevure, UniPharma, Athens, Greece).) in capsules containing: Lactobacillus acidophilus LA-5 \[1.75 × 109 colony-forming units (cfu)\], Lactobacillus plantarum (0.5 × 109 cfu), Bifidobacterium lactis BB12 (1.75 × 109 cfu) and Saccharomyces boulardii (1.5 × 109 cfu).
PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition useful for producing a liquid preparation having little side effect of hemolysis or the like, and local irritation, having excellent defoaming activity and depositing no compound of an active component as crystals by compounding a specific compound as the active component and a cyclodextrin as a stabilizer. SOLUTION: This composition is composed of (A) 2-amino-2-[2-(4-octylphenyl) ethyl]propane-1,3-diol or its pharmaceutically permissible acid adduct salt preferably in an amount of 0.1-10 wt.% based on the total amount of the composition as an active component and (B) a cyclodextrin (e.g. α-cyclodextrin) preferably in an amount of 1-50 pts.wt. based on 1 pt.wt. of the component A as a stabilizer. This composition has preferably a dosage form such as an injection, an eye drop or the like, and it is useful for suppressing rejection reaction after the transplantation of an organ or bone marrow, the maintenance immunotherapy for the transplantation, the treatment of an eye disease such as Behcet's disease or uveitis, or the like.
The early detection of classical swine fever (CSF) remains a key challenge, especially when outbreaks are caused by moderate and low-virulent CSF virus (CSFV) strains. Oral fluid is a reliable and cost-effective sample type that is regularly surveilled for endemic diseases in commercial pig herds in North America. Here, we explored the possibility of utilizing oral fluids for the early detection of CSFV incursions in commercial-size pig pens using two independent experiments. In the first experiment, a seeder pig infected with the moderately-virulent CSFV Pinillos strain was used, and in the second experiment, a seeder pig infected with the highly-virulent CSFV Koslov strain was used. Pen-based oral fluid samples were collected daily and individual samples (whole blood, swabs) every other day. All samples were tested by a CSFV-specific real-time RT-PCR assay. CSFV genomic material was detected in oral fluids on the seventh and fourth day post-introduction of the seeder pig into the pen, in the first and second experiments, respectively. In both experiments, oral fluids tested positive before the contact pigs developed viremia, and with no apparent sick pigs in the pen. These results indicate that pen-based oral fluids are a reliable and convenient sample type for the early detection of CSF, and therefore, can be used to supplement the ongoing CSF surveillance activities in North America.
Gastroesophageal varices \> 3mm in diameter will be treated with EUS guided cyanoacrylate injection for variceal obturation in standard fashion. A conventional 19G needle (19G-Echotip needle, Cook Medical, USA) will be advanced into the target varix under real-time EUS guidance. Cyanoacrylate injection (Histoacryl, B. Braun Surgical, Germany) will be performed according to established protocol. Each aliquot of cyanoacrylate injection will consist of 0.5ml of Histoacryl + 0.7ml of lipiodol. 1 - 3 aliquots of cyanoacrylate injection may be given depending on the number of varices needed to be treated. EUS with colour Doppler will be used to monitor obliteration of blood flow in varices during and after cyanoacrylate injection.
BACKGROUND: The implementation of the maternal perinatal death surveillance and response (MPDSR) policy is among the envisaged strategies to reduce the high global burden of maternal and perinatal mortality and morbidity. However, implementation of this policy across various contexts is inconsistent. Theoretically informed approaches to process evaluation can support assessment the implementation of policy interventions such as MPDSR, particularly in understanding what the actors involved actually do. In this article, we reflect on how the normalisation process theory (NPT) was used to explore implementation of the MPDSR policy in Uganda. NPT is a sociological theory concerned with the social organisation of the work (implementation) of making practices routine elements of everyday life (embedding) and of sustaining embedded practices in their social contexts (integration).
METHODS: This qualitative multiple case study conducted across eight districts in Uganda and among 10 health facilities (cases) representing four out of the seven levels of the Uganda health care system. NPT was utilised in several ways including informing the study design, structuring the data collection tools (semi-structured interview guides), providing an organising framework for analysis, interpreting and reporting of study findings as well as making recommendations. Study participants were purposely selected to reflect the range of actors involved in the policy implementation process. This included direct care providers located at each of the cases, the Ministry of Health and from agencies and professional associations. Data were collected using semi-structured, in-depth interviews and were inductively and deductively analysed using NPT constructs and subconstructs.
RESULTS AND CONCLUSION: NPT served useful for process evaluation, particularly in identifying factors that contribute to variations in policy implementation. Considering the NPT focus on the agency of people involved in implementation, additional efforts are required to understand how recipients of the policy intervention influence how the intervention becomes embedded within the various contexts.