anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in early-stage intramucosal esophageal squamous carcinoma (EIESC).
METHOD: A total of 104 samples were collected from 31 patients with EIESC and 21 healthy controls. The compositions of oral and gastric microbiota were analyzed using 16 S rRNA V3-V4 amplicon sequencing. Linear discriminant analysis effect size (LEfSe) analysis was performed to assess taxonomic differences between groups. The correlation between oral microbiota and clinicopathological factors was evaluated using Spearman correlation analysis. Additionally, co-occurrence networks were established and random forest models were utilized to identify significant microbial biomarkers for distinguishing between the EIESC and control groups.
RESULTS: A total of 292 oral genera and 223 species were identified in both EIESC and healthy controls. Six oral genera were remarkably enriched in EIESC groups, including the genera Porphyromonas, Shigella, Subdoligranulum, Leptotrichia, Paludibacter, and Odoribacter. LEfSe analysis identified genera Porphyromonas and Leptotrichia with LDA scores > 3. In the random forest model, Porphyromonas endodontalis ranked the top microbial biomarker to differentiate EIESC from controls. The elimination rate of Porphyromonas endodontalis from the oral cavity to the stomach was also dramatically decreased in the EIESC group than controls. In the microbial co-occurrence network, Porphyromonas endodontalis was positively correlated with Prevotella tannerae and Prevotella intermedia and was negatively correlated with Veillonella dispar.
CONCLUSION: Our study potentially indicates that the dysbacteriosis of both the oral and gastric microbiome was associated with EIESC. Larger scale studies and experimental animal models are urgently needed to confirm the possible role of microbial dysbacteriosis in the pathogenesis of EIESC. (Chinese Clinical Trial Registry Center, ChiCTR2200063464, Registered 07 September 2022, https://www.chictr.org.cn/showproj.html?proj=178563).
A reciprocal relationship between perceptual learning and functional brain changes towards perceptual learning effectiveness has been demonstrated previously; however, the underlying neural correlates remain unclear. Further, visual perceptual learning (VPL) is implicated in visual field defect (VFD) recovery following chronic stroke. We investigated resting-state functional connectivity (RSFC) in the visual cortices associated with mean total deviation (MTD) scores for VPL-induced VFD recovery in chronic stroke. Patients with VFD due to chronic ischemic stroke in the visual cortex received 24 VPL training sessions over 2 months, which is a dual discrimination task of orientation and letters. At baseline and two months later, the RSFC in the ipsilesional, interhemispheric, and contralesional visual cortices and MTD scores in the affected hemi-field were assessed. Interhemispheric visual RSFC at baseline showed the strongest correlation with MTD scores post-2-month VPL training. Notably, only the subgroup with high baseline interhemispheric visual RSFC showed significant VFD improvement following the VPL training. The interactions between the interhemispheric visual RSFC at baseline and VPL led to improvement in MTD scores and largely influenced the degree of VFD recovery. The interhemispheric visual RSFC at baseline could be a promising brain biomarker for the effectiveness of VPL-induced VFD recovery.
Patients who have undergone bariatric surgery and are followed in the Department of Endocrinology and Metabolism of Istanbul University Faculty of Medicine will be included in this study. Pre-treatment evaluation of the participants will be made and then individuals will be divided into two groups as Exercise Group (EG) and Control Group (CG) with a computer-assisted randomization program. The study will be conducted in accordance with the Declaration of Helsinki and a consent form will be obtained from the patients. Before the study, the purpose of the study will be explained and detailed information will be provided to the patients. CG will receive online physical activity counselling by a physiotherapist only once. EG will do online clinical pilates exercises under the supervision of a physiotherapist. The exercise program will last for 1 hour with a warm-up and cool-down period and the program will be continued twice a week for a total of 6 weeks. At the end of the treatment, individuals will be evaluated again. The primary aim is to examine the effect of online clinical pilates exercises on functionality and physical fitness in patients undergoing bariatric surgery. The secondary aim is to examine the effectiveness of telerehabilitation program after bariatric surgery.
Normoresponsive participants (with baseline epoetin alfa dosage 25-115 IU/kg/dose at study entry) will receive tiered, weight-based initial doses of roxadustat (approximately 1.3 mg/kg/dose TIW). Low weight (40 to 60 kg), medium weight (\>60 to 90 kg), and heavy weight (\>90 to 140 kg) participants will receive roxadustat 70 mg, 100 mg, and 150 mg, respectively, administered as oral capsules for 19 weeks. Dose adjustment to achieve correction and subsequent maintenance of target Hb values (11.0-13.0 g/dL) will be based upon regular monitoring of Hb.
PROBLEM TO BE SOLVED: To obtain the subject teprenone-containing pharmaceutical preparation that causes no trouble, for example, sticking, cracking, capping and the like, when they are tableted, has good appearance without bleeding of teprenone and shows high safety of the teprenone in the tablets by allowing teprenone to be adsorbed to silicon dioxide or the like. SOLUTION: (A) Teprenone is allowed to be adsorbed to (B) silicon dioxide or calcium silicate, preferably in an amount of 0.6-3 pts.wt. of the component B per 1 pt.wt. of the component A. This pharmaceutical preparation is produced by emulsifying the component A in an aqueous solution of a water-soluble polymer, for example, gum arabic, or emulsifying with (D) a surfactant such as a glycerol fatty acid ester and the resultant emulsion is allowed to be adsorbed to the component B. The amounts of the components C and D are usually 0.1-0.8 pt.wt. in case of the gum arabic and 0.02-2 pts.wt. in case of the glycerol fatty acid ester, per 1 pt.wt. of the component A, respectively.
The invention relates to a medicament for treating migraine. The medicament is prepared from the following components in parts by weight: 350 parts of kyllinga monocephala, 320 parts of Scfhisandra bicolor Cheng., 300 parts of tongking pepper, 300 parts of Radix Osterici Grosseserrati, 280 parts of Leontopodium wilsonii Beauvd., 260 parts of Pteridium revolutum (Bl.)Nakai, 250 parts of Paphiopedilum concolor, 270 parts of Ampelopsis grossedentata, 250 parts of salvia chinensis, 260 parts of gardenia, 230 parts of narrowleaf fig roots and leaves, 210 parts of Saxifraga pasumensis Marq. etShaw. f. integrifolia Jeeir, 180 parts of gmelin sealavender herb, 200 parts of Indian lettuces, 170 parts of Dicliptera chinensis and 150 parts of liquorice. All components of the medicament for treating migraine provided by the invention are natural materials, so that the medicament is relatively good in safety and suitable for clinically large-scale popularization.
Religiosity is a multidimensional construct known to influence the occurrence of hallucinations. However, it remains unknown how different religiosity types affect clinically relevant phenomenological features of hallucinations. Therefore, we wished to explore associations between intrinsic and extrinsic (non-organizational and organizational) religiosity and hallucinations severity, distress or impact on daily function in a non-clinical Muslim population. We recruited a representative sample of full-time students at Qatar's only national university via systematic random sampling and administered the Questionnaire of Psychotic Experiences online. The study design was cross-sectional. Using structural equation modeling, we estimated effects of the religiosity types on hallucinations severity, distress or impact on daily function in the past week while accounting for sociodemographic variables, anxiety, depressive symptoms, and, delusions. Extrinsic non-organizational religiosity (ENORG) was associated with experiencing reduced distress or impact on daily function from hallucinations both directly and indirectly through intrinsic religiosity. In contrast, extrinsic non-organizational religiosity (EORG) was associated with increased hallucinations distress or impact albeit only through higher intrinsic religiosity. We found no association between any religiosity types and hallucinations severity. Younger and married participants from lower socio-economic class had comparatively more severe hallucinations and more distress from them. Qatari nationality was positively associated EORG and negatively associated with hallucinations distress or impact. Evidence of differential associations between the religiosity types, socioeconomic and cultural groups, and distress or impact from past week's hallucinations supports the importance of alignment between religious, mental health, and well-being education.
The adrenal gland is a retroperitoneal organ with intimate relationships with neighboring organs but also with the large retroperitoneal vessels. Our aim was to study the vascular relationships of the adrenal gland with the large abdominal vessels. Our work is an anatomical dissection of 80 fresh cadaveric adrenals. The subjects didn't have a history of retroperitoneal surgery. Dissection conditions were similar to those in the living. All measurements were made in situ. On the right side, the average distance between the adrenal gland and the renal vein (DR) was 13 mm (0-20). In one case, the adrenal gland laid directly on the right renal vein (DR = 0). The average length L, over which the right adrenal gland entered behind the inferior vena cava (IVC), was 8 mm (0-12). In 4 cases, the right adrenal was lateral to the IVC and in 6 cases the length L exceeded 10 mm. On the left side, the mean distance DL, separating the adrenal gland from the left renal vein was 8 mm with extremes ranging from 0 mm to 18 mm. In eleven cases, the adrenal gland laid directly on the left renal vein. The right adrenal gland has a close relationship with the IVC and is often located behind it. This close relationship helps to explain the increased incidence of IVC lesions during surgery. The left adrenal gland has an intimate relationship with the left renal vein and often lies on top of it. This explains the risk of injury to the left renal pedicle during left adrenal surgery.
Bipolar disorder is a complex mental illness. Pharmacological therapy, including antipsychotics and mood stabilizers, is the primary treatment approach for manic episode. The study aimed to analyze prescribing patterns over a 14-year period for patients with bipolar mania discharged from a psychiatric hospital in Taiwan. Patients with bipolar mania discharged from the study hospital between 2006 and 2019 (n = 2956) were included in the analysis. Prescribed drugs for the treatment of manic episode, included mood stabilizers (i.e., lithium, valproate, carbamazepine) and any antipsychotics (i.e., second- and first-generation antipsychotics; SGAs & FGAs). Monotherapy, simple polypharmacy, and complex polypharmacy were also examined. Simple polypharmacy was defined as being prescribed 2 different bipolar drugs (lithium, valproate, carbamazepine, and any antipsychotics), while complex polypharmacy at least 3 bipolar drugs. Temporal trends of each prescribing pattern were analyzed using the Cochran-Armitage Trend test. The prescription rates of valproate, SGAs, and complex polypharmacy significantly increased over time, whereas the prescription rates of any mood stabilizers, FGAs, and simple polypharmacy significantly decreased. Prescription rates of lithium and monotherapy did not significantly change. The study highlights the shifts in prescribing practices for bipolar mania. SGAs were prescribed more while FGAs declined, likely due to SGAs' favorable properties. Complex polypharmacy increased, reflecting the complexity of treating bipolar disorder. Long-term outcomes of these changes require further research.
Ventilated patients with ARDS criteria (Berlin criteria) will be recruited in 3 ICU (2 from Bichat Hospital and 1 from Tenon Hospital, Paris) during the first 48 hours of their evolution. The patients will considered in 2 groups during analysis by taking into account their vital status at day-28 of inclusion.
Single-centre, double-blind, placebo-controlled, cross-over study in 33 healthy volunteers with 2 sessions. Each session consisted of a run-in day for baseline assessments, 8 treatment days and 5 additional days for followup assessments. Subjects were randomised to start with either the prucalopride or placebo session. The prucalopride dose was consecutively escalated in 2 mg steps per day, starting from 2 mg up to 10 mg once daily If a subject did not tolerate the 10- or 8-mg dose, 1 step back in the dosage scheme was allowed, from 10 to 8 mg on Day 6, or from 8 to 6 mg on Day 5. Subjects with intolerance for doses of less than 6 mg, were withdrawn from the study. Repeated dosing (6, 8 or 10 mg) was continued once daily until Day 8, to achieve steady-state. During placebo, the number of placebo tablets was consecutively escalated in an identical way as described for prucalopride. Between the 2 sessions, there was a washout period of 14 to 21 days, to avoid any carry-over effect.
The present invention relates to a method for classifying blood clots utilizing a machine learning-based gradient echo (GRE) image and a system thereof. The method comprises the following steps. An image obtaining unit obtains a GRE image. A lesion detecting unit detects a lesion region from the obtained GRE image using an artificial neural network model. A patch region setting unit sets the detected lesion region as a patch region in a constant size and resets the patch region through projection in a three-dimensional direction. A blood clot classifying unit classifies the blood clots in the patch region using the artificial neural network model.
Methodology:

The weight-bearing lunge test (WBLT) was used to evaluate the change in the ankle joint's range of motion. A simple forward bend test - the Thomayer test - was used to evaluate the therapy's effect on the Superficial fascial backline described by Myers. Both tests are non-invasive. Both tests can be used to evaluate the outcome of a given therapy objectively. Both tests are elementary to perform and highly standardized and commonly used in similar research.

After completing the entrance tests, the tissue flossing method is applied to each proband. The treatment alone does not typically last more than 20 minutes for any proband. As part of the tissue flossing treatment, both lower limbs of the proband will be treated. The "tissue flossing" method will be applied according to the authors' standard recommendations first to the plantar fascia area, then to the ankle joint. Finally, the last treated structure will be the area of fascia cruris. The duration of each application does not exceed 2 minutes. The order of individual applications is determined in advance as follows: right and then left plantar fascia, right and then left ankle joint and right and then left fascia cruris. Each application will be supplemented by the standard manual treatment or supplemented by the proband's active movement. After a total of 6 treatments, the therapeutic unit will be finished, and each proband will be re-examined using the same tests as before the treatment. If a given proband experiences any undesirable complications during the application of the "tissue flossing" method or applying the given method to the proband is subjectively unpleasant, the given treatment will be finished immediately.
<P>PROBLEM TO BE SOLVED: To obtain a composition for dry mouth having excellent activities for the increase of an amount of saliva in the oral cavity of a patient suffering from the dry mouth, the increase of resistivity of the saliva against decayed tooth, the amelioration of periodontal diseases, and the like.  <P>SOLUTION: This composition for the dry mouth contains a lactic bacterium and xylitol as active ingredients. The lactic bacterium is Lactobacillus salivarius. Live lactic bacteria (e.g. the live bacterial cells, wet bacteria and dried bacteria), a cultured product of the lactic bacteria (bacterial cells, supernatant of cultured liquid and medium components) can be used appropriately.  <P>COPYRIGHT: (C)2004,JPO
FIELD: veterinary microbiology. SUBSTANCE: deep anaerobic cultivation of B. anthracis strain upon nutritive medium containing sodium bicarbonate should be carried out in fermenter by continuously aerating culture liquid either with gas or mixture of several gases (argon, helium, nitrogen, etc.). Moreover, native protective antigen could be obtained in fermenters by mixing and surface aeration of culture liquid (CL) with different gases or at bubbling method of CL mixing, only. Moreover, gas expenditure corresponds to 0.05-0.40 l/min/l CL. The method enables to increase anthracic antigen output by 2-4 times and decrease terms of its accumulation at cultivation stage up to 15-20 h. EFFECT: higher efficiency. 2 ex, 2 tbl
Zika virus (ZIKV) infection was first reported in 2015 in Brazil as causing microcephaly and other developmental abnormalities in newborns, leading to the identification of Congenital Zika Syndrome (CZS). Viral infections have been considered an environmental risk factor for neurodevelopmental disorders outcome, such as Autism Spectrum Disorder (ASD). Moreover, not only the infection per se, but maternal immune system activation during pregnancy, has been linked to fetal neurodevelopmental disorders. To understand the impact of ZIKV vertical infection on brain development, we derived induced pluripotent stem cells (iPSC) from Brazilian children born with CZS, some of the patients also being diagnosed with ASD. Comparing iPSC-derived neurons from CZS with a control group, we found lower levels of pre- and postsynaptic proteins and reduced functional synapses by puncta co-localization. Furthermore, neurons and astrocytes derived from the CZS group showed decreased glutamate levels. Additionally, the CZS group exhibited elevated levels of cytokine production, one of which being IL-6, already associated with the ASD phenotype. These preliminary findings suggest that ZIKV vertical infection may cause long-lasting disruptions in brain development during fetal stages, even in the absence of the virus after birth. These disruptions could contribute to neurodevelopmental disorders manifestations such as ASD. Our study contributes with novel knowledge of the CZS outcomes and paves the way for clinical validation and the development of potential interventions to mitigate the impact of ZIKV vertical infection on neurodevelopment.
The study will compare two approaches to pre-colonoscopy cleanout, one with traditional laxatives only, and one with laxatives + anti-emetic therapy. The medication to be added will be Ondansetron (brand name: Zofran). Classically, the bowel prep entails drinking large amounts of water with an osmotic laxative and being only on a liquid diet the day prior to the procedure. Drinking this mixture of water with an osmotic laxative may cause nausea and discomfort in some patients that may prevent them from finishing the bowel prep. This will therefore affect the visualization of the colon during the procedure, as there will still be retained, hard stool. Having large amounts of stool in the colon during the procedure can make the colonoscopy more difficult, takes a longer time to complete, can make the study inconclusive, unable to properly diagnose, and difficult to take biopsies. This study assesses the impact of anti-emetic medication (ondansetron) on the bowel prep experience with the goal of improving participant tolerance and preparation success. This will eliminate concern for retained stool and less chance of cancelling a procedure due to improper bowel prep.
Initiation of NIV treatment implies technical adjustments (choice of mask and ventilator), but also patient education by the nurses and medical staff. The settings are generally adjusted during the daytime in awake patients. The appropriateness of these settings is generally not optimal during sleep as many respiratory events (hypopnoea, apnea, leaks, desynchronization, and glottic closure) may occur under NIV then reducing the effectiveness of treatment. These nocturnal abnormalities are routinely evaluated by measuring their consequences, i.e. oxygen desaturation and the level of PaCO2 after wake up. Some teams are now proposing to better characterize what happens when using NIV during sleep using polysomnography (PSG). The precise characterization of residual events under treatment may allow optimizing ventilator settings.
PURPOSE: To provide a antitumor agent which contains a protein tyrosine phosphatase α inhibitor and has a high level of pp60<c-src> kinase activity. CONSTITUTION: This agent contains a protein tyrosine phosphatase(PTP) αinhibitor as an active ingredient. The PTP α inhibitor contains zinc ions, a vanadate such as sodium orthovanadate and an arsenite such as oxophenylarsine and is a polyclonal or monoclonal antibody and directly acts on PTP α. Intrinsic PTP α is inhibited by cDNA encoding mutant PTP α through gene transduction. The agent can be prepared in the form of an injection, tablets, granules, a powder, capsules, a suppository, or the like. The does is 0.05 to 500 mg/day at the time of performing injection administration, or 0.05 to 1,000 mg/day at the time of performing oral or intracetal administration. The agent is particularly useful for treating colon-rectum cancer.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic capable of efficiently removing an acidic dyeing agent without impairing hair by including a cationic surfactant, a specific organic solvent, a lower alcohol or a lower polyol and an alkali component. SOLUTION: This hair cosmetic comprises (A) a cationic surfactant [e.g. a compound of formula I (at least one of R<1> to R<4> is an 8-28C alkyl or the like and the residue is a 1-3C alkyl or the like; X is a halogen or a 1-2C alkylslfate group) or a compound of formula II (R<5> is an 8-28C alkyl; Y is a halogen), e.g. cetyltrimethyl ammonium chloride or stearyltrimethyl ammonium], (B) one or more kinds of organic solvents selected from an N- alkylpyrrolidone, a lower alkylene carbonate and an aromatic alcohol (e.g. benzyl alcohol or benzyloxyethanol), (C) a lower alcohol or a lower polyol (e.g. ethanol) and (D) an alkali component (e.g. triethanolamine).