anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory and scarring disease with a wide spectrum of disease severity. The amount of scarring is proportional to the preceding tissue damage and poses a challenge to patients. Severe HS is most often treatment recalcitrant, but hypothetically avoidable through early biologic treatment. Early prediction of individual risk of disease progression is therefore essential for patient management.
OBJECTIVES: To investigate risk factors associated with disease progression and to design an algorithm capable of predicting disease -progression.
METHODS: A prospective cohort study of 335 Hurley III-naïve patients with HS, not treated with biologics, was followed for a median of 2 years. Potential risk factors covered basic demographics, HS anamnestic factors and clinical HS factors collected during physical examination. Two separate Cox proportional hazard regression (CPHR) analyses were conducted. A summated 'progression score' was calculated and used in the predictive algorithm of severe disease. Subsequent bootstrap sampling was used to validate the predictability of the predictive algorithm.
RESULTS: The CPHR analysis of Transition to severe disease found that active smoking [hazard ratio (HR) 4.01, 95% confidence interval (CI) 1.71-9.40, P = 0.001]; body mass index (BMI) points > 25 at baseline (each point: HR 1.06, 95% CI 1.02-1.09, P < 0.001); active disease in 2 (HR 4.26, 95% CI 1.23-14.84, P = 0.02) and ≥ 3 areas (HR 6.54, 95% CI 1.89-22.72, P = 0.003) all constituted substantial risk factors. Conversely, the CPHR analysis of Disease progression did not yield results of clinical relevance. A 'progression score' of 3.04 was used as a threshold in the predictive algorithm of Transition to severe disease and achieved the following test specifics: sensitivity = 0.51, specificity = 0.86, positive predictive value = 0.50, negative predictive value = 0.86.
CONCLUSIONS: We found a disparity between factors increasing the risk of simple Disease progression and those increasing the risk of Transition to severe disease. For the latter, active smoking, BMI points > 25, active disease in 2 or ≥ 3 areas were all shown to be the clinically relevant factors that could be used to construct an algorithm that correctly predicted progression to severe HS in more than half of all instances.
The patient will be positioned supine. The operating limb may be positioned abducted or adducted by side depending on operator preference and patient factors. After standard preparation, the needle will be directed towards the target area using an in-plane, short-axis technique. Local anaesthetic (lidocaine 2% with epinephrine 1:200.000) will be injected posterior to the artery with the intention achieving the U shape, cranio-postero-caudal spread. Local anaesthetic will be deposited to the lateral and medial cords as well, if required. The total dose of the local anaesthetic will be 20-30 ml, as clinically indicated.
BACKGROUND: Day-case laparoscopic cholecystectomy (DCLC) has gained traction globally due to its benefits, including shorter hospital stays, reduced costs, and enhanced patient experience. While concerns about patient safety, particularly related to bleeding and bile duct injury persist, the literature supports the efficacy and advantages of DCLC highlighting the need for its wider adoption in healthcare settings to optimise resources and improve patient outcomes.
METHODS: This was a literature review that aims to assess the feasibility and safety of day-case laparoscopic cholecystectomy for symptomatic gallstone patients, focusing on incidence and aetiology of unexpected admissions and readmissions, as well as conversion-to-open rates. PubMed was searched for all studies focusing on DCLC between 2014 and 2024. The timeframe was specifically selected to identify recent trends and practices in this evolving field. By focusing on this specific period, the review aims to provide a comprehensive analysis of current practices, emerging trends, and the evolving standard of care in this area.
RESULTS: This review highlights that the main causes of unexpected admission post DCLC were postoperative nausea, vomiting, and pain, while the implementation of anaesthetic pathways notably increased day-case rates. Studies addressing complication rates postoperatively consistently found no significant difference between day-case and in-patient procedures.
CONCLUSIONS: DCLC for symptomatic gallstone patients is supported by research as safe and effective, with high success rates and patient satisfaction. Studies show minimal complications and acceptable readmission rates, suggesting that DCLC can be the standard approach for selective patients, improving outcomes and healthcare efficiency.
PURPOSE: An imaging and carrying dual functional nano-particle-based vaccine carrier is provided to not show toxicity and side effects in vivo. CONSTITUTION: A vaccine carrier comprises a gold nano-particle or magnetic nano-particle as imaging and carrying dual functional particle and an antigen combined in the surface of the imaging and carrying dual functional particle. The vaccine carrier traces the delivery of antigen and delivers antigen. The antigen is microorganism originated antigen, virus originated antigen, parasite originated antigen, plant originated antigen, animal originated antigen, endogenous antigen or synthetic antigen. The vaccine carrier additionally includes adjuvant. The vaccine carrier is combined with the surface of an immunoadjuvant or an antigen. The immunoadjuvant is CpG oligodeoxynucleotide, and unmethylated cystein-phosphate-guanine DNA, duplex RNA, microorganism originated DNA or RNA, nucleic acid derivative, lipid, lipopolysaccharide, lipoprotein, lipopeptid, glycolipid, glycopeptide, protein, recombinant protein, flagellin, virosome, saponin, squalene, or nucleic acid derivative.
Xiaopi granules have a dosage of 18 g per bag, 18 g per administration, twice daily, for a total of 8 days per treatment course. The duration of the treatment course will align with that of the chemotherapy regimen. The neoadjuvant chemotherapy is developed based on the National Comprehensive Cancer Network (NCCN) guidelines. Different treatments and doses are according to the standard recommendations outlined in the guidelines. Treatment options may include AC-T, ECT, EC, TC, AC, TAC, TP, etc.
PURPOSE: To create and evaluate prediction models of local tumor recurrence after successful conventional transcatheter arterial chemoembolization (c-TACE) via radiomics analysis of lipiodol deposition using cone-beam computed tomography (CBCT) images obtained at the completion of TACE.
MATERIALS AND METHODS: A total of 103 hepatocellular carcinoma nodules in 71 patients, who achieved a complete response (CR) based on the modified Response Evaluation Criteria in Solid Tumors 1 month after TACE, were categorized into two groups: prolonged CR and recurrence groups. Three types of areas were segmented on CBCT: whole segment (WS), tumor segment (TS), and peritumor segment (PS). From each segment, 105 radiomic features were extracted. The nodules were randomly divided into training and test datasets at a ratio of 7:3. Following feature reduction for each segment, three models (clinical, radiomics, and clinical-radiomics models) were developed to predict recurrence based on logistic regression.
RESULTS: The clinical-radiomics model of WS showed the best performance, with the area under the curve values of 0.853 (95% confidence interval: 0.765-0.941) in training and 0.752 (0.580-0.924) in test dataset. In the analysis of radiomic feature importance of all models, among all radiomic features, glcm_MaximumProbability, shape_MeshVolume and shape_MajorAxisLength had negative coefficients. In contrast, shape_SurfaceVolumeRatio, shape_Elongation, glszm_SizeZoneNonUniformityNormalized, and gldm_GrayLevelNonUniformity had positive coefficients.
CONCLUSION: In this study, a machine-learning model based on cone-beam CT images obtained at the completion of c-TACE was able to predict local tumor recurrence after successful c-TACE. Nonuniform lipiodol deposition and irregular shapes may increase the likelihood of recurrence.
We describe the case of a 64-year-old woman with haemoptysis due to a mycotic thoracic aneurysm, with probable fistulation into the lung and oesophagus. Continuous subcutaneous tranexamic acid was used at the end of life to minimise bleeding associated with this, once the oral route was lost. A 1.5 g of tranexamic acid was administered, diluted with 23 mL water for injection in a 30 mL syringe, as a continuous subcutaneous infusion over 24 hours. Bleeding ceased rapidly following administration. There was no further bleeding in the last days before death and no site reaction noted. This case report adds to the growing evidence base for the use of subcutaneous tranexamic acid in a palliative care setting. However, further research is needed to support this practice both in terms of efficacy and safety, but also terms of compatibility and stability when administered by continuous subcutaneous infusion.
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately 1% of the global population, with a higher prevalence in women than in men. Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of RA. Anethole, a prominent compound derived from fennel (Foeniculum vulgare), possesses a spectrum of therapeutic properties, including anti-arthritic, anti-inflammatory, antioxidant, and tumor-suppressive effects. However, its specific impact on RA remains underexplored. This study sought to uncover the potential therapeutic value of anethole in treating RA by employing an H2 O2 -induced inflammation model with HIG-82 synovial cells. Our results demonstrated that exposure to H2 O2 induced the inflammation and apoptosis in these cells. Remarkably, anethole treatment effectively countered these inflammatory and apoptotic processes triggered by H2 O2 . Moreover, we identified the aquaporin 1 (AQP1) and protein kinase A (PKA) pathway as critical regulators of inflammation and apoptosis. H2 O2 stimulation led to an increase in the AQP1 expression and a decrease in p-PKA-C, contributing to cartilage degradation. Conversely, anethole not only downregulated the AQP1 expression but also activated the PKA pathway, effectively suppressing cell inflammation and apoptosis. Furthermore, anethole also inhibited the enzymes responsible for cartilage degradation. In summary, our findings highlight the potential of anethole as a therapeutic agent for mitigating H2 O2 -induced inflammation and apoptosis in synovial cells, offering promising prospects for future RA treatments.
Veterinary compositions suitable for oral administration to domestic livestock comprise not less than 0.1% by weight of cyanacethydrazide, at least one additional component selected from stabilizing agents for cyanacethydrazide and compounds of known veterinary utility when administered orally, and optionally a non-toxic diluent or diluent mixture. The stabilizing agent which may be present between 0.05% and 5% by weight, is one or more water-soluble sulphur oxyacids and/or the salts thereof which possess reducing properties, e.g. sulphur dioxide in the form of sulphurous acid, sulphites, metabisulphites, hydrosulphites, particularly the alkali metal, e.g. sodium, or alkaline earth metal salts. The compounds of known veterinary utility may be an antibacterial, e.g. sulphonamides such as sulphadimidine, an antibiotic, e.g. penicillin, potassium penicillin V, an antihelmintic agent, e.g. phenothiazine, hexachloroethane, piperazine and its derivatives such as tripiperazine dicitrate, 1-diethyl carbamyl-4-methyl piperazine and the dihydrogen citrate thereof, piperazine diacetate, piperazine dihydrochloride and mineral salt mixtures, e.g. mixtures containing sodium and magnesium salts. Suitable diluents may be liquid, e.g. water or milk, or solid which may be soluble or insoluble in water, e.g. chalk, kaolin, talc, urea, lactose, other known pharmaceutical excipients and animal foodstuff, e.g. maize starch paste, ground oats, mucilage of tragacanth. Other adjuvants include dispersing agents such as phenol-ethylene oxide condensation products, e.g. condensation product of p-cresol with 8-10 molecular proportions of ethylene oxide, of formaldehyde and naphthalene sulphonic acids, e.g. sodium di-isopropyl naphthalene sulphonate, disodium methylene-bis-naphthalene-2-sulphonate fatty acid esters of glycerol, e.g. polyglyceryl ricinoleate anti-caking agents, e.g. calcium phosphate, magnesium sulphate and stearate suspending agents, e.g. hydrated aluminium silicate, sodium chloride. The composition may take the form of aqueous solutions or suspensions, powders or premixes suitable for admixture with animal feeding stuff, tablets or capsules, e.g. gelatin capsules, and in animal feeding stuffs. Specifications 817,143, 817,358, 817,380 and 818,467 are referred to.
Text4Baby automated texts sent to participants' cellular phones 3-5 times per week from Week 25 of pregnancy through the postpartum period from the national Text4Baby system. Messages provide general prenatal and postpartum support, including breastfeeding.
A cleaning agent system comprising a foam dispenser and a cleaning agent in which the surfactant content of the cleaning agent comprises 95-100 wt.%. biosurfactant. The cleaning agent may be provided as a concentrate and may be provided in a bag. The foam dispenser may be a foam pump. The biosurfactant may comprise glycolipids, such as rhamnolipid, sophorolipid or mannosylerythritol lipid, or lipopeptides such as surfactin, fatty acyl glutamates or fatty acyl glycinates or combinations thereof. The carrier may be water. The cleaning agent may be a cosmetic cleaning agent, in particular for the face, body or hands. Other ingredients including thickeners, preservatives, perfumes or caring substances may be present.
Therapeutic hypothermia will be achieved using a servo-controlled temperature regulating blanket that is approved for use in neonates and is currently used for the treatment of neonates with moderate-severe HIE. The goal target temperature is 33.5°C ± 0.5°C for 72 hours and the subject will then be rewarmed at a rate of 0.5°C per hour to a goal of 36.5°C.
BACKGROUND AND OBJECTIVES: Slow-burning inflammation at the edge, and chronic demyelination at the core, of established multiple sclerosis (MS) lesions are potential mediators of disease progression. However, their relative contribution to progressive axonal damage has not been explored. Therefore, in this study, we investigated the comparative contribution of slow-burning inflammation and chronic demyelination to axonal attrition within MS lesions by measuring progressive tissue rarefaction. In addition, we use the visual system as a model to investigate the effect of chronic demyelination on the acceleration of axonal death in a sub-group of patients with unilateral optic neuritis.
METHODS: Pre- and post-gadolinium 3D-T1, 3D FLAIR, diffusion tensor images, Optical Coherence tomography and multifocal visual evoked potentials were acquired from 52 relapsing-remitting MS patients who completed at least 5 years follow-up. Lesion expansion was measured using custom software, and the rate of tissue rarefication inside lesion core was assessed by measuring increase of normalized mean diffusivity (nMD). Axonal loss was also examined in eyes with severe optic nerve demyelination.
RESULTS: Among the 361 lesions analyzed, 104 were expanding (a minimum of 4 % expansion per year) and 257 were stable. Expanding lesions showed a significantly higher rate of progressive tissue rarefication inside lesion (1.12 % per year) core compared to stable lesions (0.21 % per year, p = 0.01). The magnitude of nMD change was significantly correlated with the rate of lesion expansion (r = 0.4, p < 0.001). Analysis of retinal ganglion cells in eyes with severe optic nerve demyelination (Inter-eye latency delay of >10 ms) revealed a similar rate of axonal loss (0.19 %) to the degree of tissue rarefaction observed in stable lesions (0.21 %).
DISCUSSION: The results of the study suggest that the slow-burning inflammation at the lesion's edge (as measured by lesion expansion), is likely to have a greater impact on tissue damage (as measured by nMD change), when compared to stable chronically demyelinated lesions. The similar modest degree of tissue damage was also observed in chronically demyelinated fibers of the optic nerve.
A method for prognosticating risk of a clinical outcome for a patient comprises receiving 51 clinical data relating to the patient; generating 52 a histological index based on infrared absorption data gathered 61 from a sample e.g. tissue of the patient; and generating 53 a prognosticated risk score based on the histological index and the clinical data. The clinical outcome may be death, disease-specific death, recurrence or complete pathological response. The patient may be a breast, colon, prostate or renal cancer patient, and the clinical data may be age when diagnosed, menopausal status, tumour size or grade. The method may use a multivariate logistic model, and may calculate a hazard ratio using a logistic regression model. The IR absorption data may be at selected wavelengths. The index may be a ratio of the energy absorbed attributable to an amide moiety and the energy absorbed attributable to a phosphate moiety. The IR data may be obtained with an interferometer, Raman spectroscopy spectral imager, spectral detector or wavelength tuneable light source.
OBJECTIVE: The primary objective was to establish a radiomics model utilizing longitudinal +cross-sectional ultrasound (US) images of lymph nodes (LNs) to predict cervical lymph node metastasis (CLNM) following differentiated thyroid carcinoma (DTC) surgery.
METHODS: A retrospective collection of 211 LNs from 211 postoperative DTC patients who underwent neck US with suspicious LN fine needle aspiration cytopathology findings at our institution was conducted between June 2021 and April 2023. Conventional US and clinicopathological information of patients were gathered. Based on the pathological results, patients were categorized into CLNM and non-CLNM groups. The database was randomly divided into a training cohort (n = 147) and a test cohort (n = 64) at a 7:3 ratio. The least absolute shrinkage and selection operator algorithm was applied to screen the most relevant radiomic features from the longitudinal + cross-sectional US images, and a radiomics model was constructed. Univariate and multivariate analyses were used to assess US and clinicopathological significance features. Subsequently, a combined model for predicting CLNM was constructed by integrating radiomics, conventional US, and clinicopathological features and presented as a nomogram.
RESULTS: The area under the curves (AUCs) of the longitudinal + cross-sectional radiomics models were 0.846 and 0.801 in the training and test sets, respectively, outperforming the single longitudinal and cross-sectional models (p < 0.05). In the testing cohort, the AUC of the combined model in predicting CLNM was 0.901, surpassing that of the single US model (AUC, 0.731) and radiomics model (AUC, 0.801).
CONCLUSIONS: The US-based radiomics model exhibits the potential to accurately predict CLNM following DTC surgery, thereby enhancing diagnostic accuracy.
BACKGROUND AND PURPOSE: Neuropathic pain affects millions of patients, but there are currently few viable therapeutic options available. Microtubule affinity-regulating kinases (MARKs) regulate the dynamics of microtubules and participate in synaptic remodelling. It is unclear whether these changes are involved in the central sensitization of neuropathic pain. This study examined the role of MARK1 or MARK2 in regulating neurosynaptic plasticity induced by neuropathic pain.
EXPERIMENTAL APPROACH: A rat spinal nerve ligation (SNL) model was established to induce neuropathic pain. The role of MARKs in nociceptive regulation was assessed by genetically knocking down MARK1 or MARK2 in amygdala and systemic administration of PCC0105003, a novel small molecule MARK inhibitor. Cognitive function, anxiety-like behaviours and motor coordination capability were also examined in SNL rats. Synaptic remodelling-associated signalling changes were detected with electrophysiological recording, Golgi-Cox staining, western blotting and qRT-PCR.
KEY RESULTS: MARK1 and MARK2 expression levels in amygdala and spinal dorsal horn were elevated in SNL rats. MARK1 or MARK2 knockdown in amygdala and PCC0105003 treatment partially attenuated pain-like behaviours along with improving cognitive deficit, anxiogenic-like behaviours and motor coordination in SNL rats. Inhibition of MARKs signalling reversed synaptic plasticity at the functional and structural levels by suppressing NR2B/GluR1 and EB3/Drebrin signalling pathways both in amygdala and spinal dorsal horn.
CONCLUSION AND IMPLICATIONS: These results suggest that MARKs-mediated synaptic remodelling plays a key role in the pathogenesis of neuropathic pain and that pharmacological inhibitors of MARKs such as PCC0105003 could represent a novel therapeutic strategy for the management of neuropathic pain.
Patients receive eribulin mesylate IV over 2-5 minutes and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 courses in the absence of disease progression or unacceptable toxicity.
The application discloses a doctor recommendation method, which comprises the following steps: the method comprises the steps of obtaining a first message input by a user, wherein the first message is a message with a doctor query intention, and the first message comprises first professional skills. And determining the doctor corresponding to the first professional skill according to the corresponding relation between the doctor and the professional skill which the doctor excels in, and outputting the information of the determined doctor. The expert skills which are good for doctors and are included in the corresponding relation are determined according to first doctor information of the doctors, and the first doctor information at least comprises post information and/or scientific research academic information. The relevance between the job information and/or the scientific research academic information and the professional skills is high, and the influence of the subjective factors on the job information and/or the scientific research academic information is small, so that the credibility of the job information and/or the scientific research academic information is high. Therefore, the accuracy of the professional skills in the aforementioned correspondence relationship is relatively high. Therefore, the doctor meeting the user requirements can be accurately recommended to the user by utilizing the scheme.
<P>PROBLEM TO BE SOLVED: To provide a living body information control system which synchronizes measurement data by absorbing a time difference between characteristics among individuals in living body sensors and an internal clock.  <P>SOLUTION: Two kinds of modes such as a detection mode and a measurement mode are provided as an action mode in the living body information control system. In the detection mode, one of plural sensor terminals 1 is made to be a standard sensor terminal 1', and a time is set in the internal clock in the standard sensor terminal 1' from a data controlling device 3. In addition, an identical input is given to the standard sensor terminal 1' and the other sensor terminals 1, and output information in the sensors is compared by the data controlling device 3. Time difference information is calculated so that most coincident points of change in output information and the standard sensor terminal 1' become at the identical time, and stored in the data controlling device 3.  <P>COPYRIGHT: (C)2005,JPO&NCIPI