anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Stabilised compsns. capable of releasing an active agent (I) on contact with the skin contain at least two precursors capable of simultaneously releasing (I) by different enzymatic reactions at a rate greater than the sum of the rates of the individual reactions. Also claimed is a compsn. as above where (I) is vitamin C. (I) is pref. selected from vitamins, lipopeptides, lipoamino acids, alpha- or beta-hydroxy acids, antioxidants and hydrating agents, esp. ascorbic acid, retinol, tocopherol, quercetin, lactic acid or glycerol. (II) is a palmitate, acetate, propionate, nicotinate, sulphate ester, phosphate ester (esp. ascorbyl phosphate), glyceride or ferulate and (III) is a glycosylated deriv. (esp. glucosylated ascorbic acid)
Lung cancer has a high prevalence, incidence and mortality in France and worldwide. Surgical treatment, possible only at an early stage, improves the prognosis of patients. In addition, the increasing accessibility of chest CT scans allows early detection and monitoring of small pulmonary nodules. As a result, more conservative surgical techniques are becoming increasingly important, including segmentectomy.

Among patients for whom it is indicated, the preoperative assessment involves the evaluation of pulmonary function and the prediction of postoperative pulmonary function in order to validate the feasibility of surgery. To do this, several methods have been described: anatomical methods (segment counting), radiological imaging methods (CT, DECT, perfusion MRI), and nuclear imaging methods (planar perfusion and/or ventilation pulmonary scintigraphy, SPECT pulmonary perfusion scintigraphy), some of which are hybrid (SPECT/CT). The use of SPECT/CT to predict postoperative pulmonary function is routinely practiced, and its reliability, accuracy, and concordance with measured postoperative pulmonary function are well demonstrated for pneumectomy and lobectomy. For more conservative surgeries, the data in the literature remain uncertain. However, being able to predict pulmonary function is essential, both to justify the feasibility of the intervention, but also to target the most fragile patients and intensify their postoperative respiratory rehabilitation.
Prognosis in relapsing malignant brain tumors is poor. Those in brain stem gliomas is dismal; median survival of these children does not exceed 9 months. Radiation therapy may result in early and transient amelioration of symptoms, but have not contributed to increase or prolong survival. Moreover, chemotherapy has not increased this outcome to date.Prados et al. reported encouraging results from a phase I study of TarcevaTM/OSI-774 alone or with temozolomide (TMZ) in patients with malignant gliomas. Of 25 evaluated patients, 6 experienced PR: 4 GBM (glioblastoma multiforme) and 1 grade 3 astrocytoma treated with TarcevaTM alone, 1 GBM treated with TarcevaTM/TMZ; 2 had minor responses, and 3 stable diseases. These results in malignant glioma and the lack of efficacy in brain stem glioma with current treatment suggests the evaluation of this new therapeutic agent in children with relapsed brain tumors and upfront at diagnosis in brain stem glioma in combination with radiation therapy.
The investigation design will include an enrolment and randomisation visit followed by an at home in-use period and a final follow up phone call. The enrolment visit will include confirmation of eligibility and collection of baseline data, including baseline pain scores using the Visual Analogue Scale (VAS), medical history, demographics, and baseline Patient Reported Outcomes (PRO) assessments. Baseline data collected will be assessed to confirm eligibility before randomisation, first product application (treatment group only), initial pain (VAS) Participant Perceived Questionnaires (PPQ) and PRO assessments. During the at home in-use period, those participants randomised to the treatment group will reapply the product daily, complete pain assessments using the VAS (morning and evening), PPQs and PROs (Day 3 evening only). For participants randomised to the no-treatment group, they will complete pain assessments using the VAS (morning and evening) and PROs (Day 3 evening). All participants will continuously record Adverse Events (AE) and changes to concomitant medication throughout this period. During the follow up phone call, the participants will be contacted to establish any further AEs and/or changes to concomitant medication, additionally any queries related to diary entries will be made during this phone call. Participants will not need to return to the site unless advised to do so by the Principal Investigator (PI) or delegate.

After completion of the investigation, the Investigator will make an Assessment of Tolerance for each subject based on their pain scores (VAS), PPQ responses and AEs reported.
The public health workforce continues to experience staff shortages, which hampered the ability of US state, tribal, local, and territorial health departments to respond to the COVID-19 pandemic. In April 2020, the US Centers for Disease Control and Prevention (CDC) awarded $45 million to the CDC Foundation to provide field assignees to support these health departments. To expand these efforts, the CDC provided an additional $20 million in May 2021 for vaccination efforts and $200 million in June 2021 to support COVID-19 response and general infrastructure support. The CDC Foundation worked with jurisdictions across the United States to develop job descriptions based on need and recruit nationally for positions. This expanded project, called the Workforce/Vaccine Initiative, hired 3,014 staff in 91 jurisdictions, with 2,310 (77%) hired by January 2022. Most assignments were fully remote (55%) or hybrid (28%). The largest number of staff (n=720) supported COVID-19 response work in schools. Other common functions included contact tracing/case investigation (n=456), program coordination (n=330), epidemiology (n=297), data and surveillance (n=283), and administrative support (n=220). To advance health equity and improve response efforts, 79 health equity staff were assigned to 30 jurisdictions. To support the needs of tribes, 76 field staff supported 22 tribal entities. This project demonstrated the important role of a flexible, centralized approach to rapid placement of staff in public health departments during an emergency response. While the goal of the Workforce/Vaccine Initiative was to meet short-term staffing needs, lessons learned could provide insights for building a sustainable and scalable public health workforce.
The invention discloses an antiviral traditional Chinese medicine composition, a preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The composition takes honeysuckle and weeping forsythiae capsule as monarch drugs and is used for clearing heat and detoxicating and dispelling wind and heat; radix Platycodi, parched fructus Arctii and herba Menthae are used as ministerial drugs for dispelling pathogenic wind, dispersing lung qi and relieving sore throat; with the addition of fineleaf schizonepeta herb for dispelling wind and relieving exterior syndrome, thunberg fritillary bulb for clearing heat and removing blood stasis, and vinegar schisandra chinensis, figwort root and red paeony root, the Chinese medicinal composition has the effects of tonifying qi and promoting the production of body fluid, nourishing yin and cooling blood and detoxifying; the licorice enters lung meridian, has the effects of detoxifying, clearing heat, resolving phlegm and relieving pain, and harmonizing various medicines. The above medicines are combined together to play a role in clearing heat and detoxicating, dispelling wind and dissipating heat. Has effects in clearing away heat and toxic materials, relieving inflammation and fever, eliminating pathogenic factors, and relieving exterior syndrome. Can be used for treating wind-heat invading lung type acute upper respiratory tract infection and influenza. Is mainly used for treating wind-heat type common cold and influenza. The preparation is a mixture, so that the effective storage time of the product is prolonged, and the convenience in use and carrying is improved.
Do not initiate venlafaxine treatment, titrate by doses less than 112.5 mg, or taper treatment with Venlafaxine Extended-Release Tablets, as dosing is not possible in these scenarios because Venlafaxine Extended-Release Tablets are only available in a 112.5 mg strength. Use another venlafaxine extended-release product for dosage initiation, titration, administration of dosages below 112.5 mg once daily, and to taper during discontinuation [see Dosage and Administration (2.6, 2.7, 2.8)]. Refer to the Prescribing Information of other venlafaxine extended-release products for the recommended dosage of those products in these dosing scenarios.

Venlafaxine Extended-Release Tablets can be initiated in patients who have received at least 75 mg per day of another venlafaxine extended-release product for at least 4 days [see Dosage and Administration (2.2, 2.3)].

Administer Venlafaxine Extended-Release Tablets as once daily with food, either in the morning or in the evening at approximately the same time each day [see Clinical Pharmacology (12.3)]. Swallow tablets whole with fluid. Do not divide, crush, chew, or place in water.
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3beta or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3beta protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3beta protein or GSK-3beta protein complexes.
Deoxynivalenol (DON) can induce endoplasmic reticulum (ER) stress, mitochondrial ROS burst, and macrophage polarization. Here, we investigated the mechanism linking the above three aspects with the dose range relevant to low-level exposure in children. At 0.5 μg/kg bw/day, we found remarkable liver and gut inflammatory responses after 6-week exposure in mice age comparable to humans 7-12 years old. Through antioxidant intervention, we found that ROS played a driver role in macrophage polarization and inflammatory responses induced by DON in the liver and gut. Further bioinformatics analysis uncovered that ER stress-associated protein MAPK7 (ERK5) may bind with AhR to initiate a mitochondrial ROS burst and macrophage M1 polarization. The downstream cellular events of MAPK7-AhR interaction may be mediated by the AhR/STAT3/p-STAT(Ser727) pathway. This mechanism was further supported by DON toxicity mitigation using cyanidin-3-glucoside (C-3-G), which docks to MAPK7 oligomerization region 200-400 aa and disrupts MAPK7-AhR interaction. Overall, our study provides novel evidence and mechanism for DON-induced inflammatory responses in the liver and gut system. Our findings call attention to the health risks associated with low-level DON exposure in the prepuberty children population.
The present technique provides a novel method and apparatus for generating a multi-media patient summary which integrates patient information including a wide range of information having disparate formats and originating from isolated systems. The multi-media may be delivered to care providers and patients for use in medical diagnosis and care. The contents of the multi-media patient summary may be tailored to meet the needs of the specific care provider, and may include, for example, clinical data, patient demographics, and reference materials. The summary may be a digital file that encapsulates patient information having formats, such as text, images, sound files, video, waveforms, hypertext links, and so forth. The file may be encrypted and require a proprietary or non-proprietary reader to view. Additionally, the flow of information may be bi-directional between the multi-media patient summary and users of the summary.
CHARISMA 

The CHARISMA trial was a 15,603 subject, randomized, double-blind, parallel group study comparing Plavix (75 mg daily) to placebo for prevention of ischemic events in patients with vascular disease or multiple risk factors for atherosclerosis. All subjects were treated with aspirin 75–162 mg daily. The mean duration of treatment was 23 months. The study failed to demonstrate a reduction in the occurrence of the primary endpoint, a composite of CV death, MI, or stroke. A total of 534 (6.9%) patients in the Plavix group versus 573 (7.4%) patients in the placebo group experienced a primary outcome event (p=0.22). Bleeding of all severities was more common in the subjects randomized to Plavix.
Chronic pain is a debilitating condition for many military Veterans and is associated with posttraumatic stress disorder (PTSD). This study examined the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) in 144 Veterans (88.2% male, mean age = 57.95 years) recruited from a VA outpatient pain clinic and associations with self-reported pain severity, pain-related interference in daily activities, prescription opioid use, and objective metrics of physical performance on tasks impacted by pain (walking, stair climbing, grip strength, indexed by a single latent variable). Among the cohort with valid responses on the MMPI-2-RF (n = 117) and probable PTSD, mean Somatic Complaints (RC1) and Ideas of Persecution (RC6) scores were clinically elevated. All MMPI-2-RF scales were more strongly correlated with self-reported pain interference than severity. Regressions revealed associations between self-rated pain interference (but not pain or PTSD severity) and physical performance scores (β = .36, p = .001). MMPI-2-RF overreporting Validity and Higher-Order scales contributed incremental variance in predicting physical performance, including Infrequent Psychopathology Responses (β = .33, p = .002). PTSD severity was associated with prescription opioid use when accounting for the effects of over-reported somatic and cognitive symptoms (odds ratio 1.05, p ≤ .025). Results highlight the role of symptom overreporting and perceptions of functional impairment to observable behaviors among individuals with chronic pain.
BACKGROUND: Magnetic resonance (MR) imaging is the most common modality for assessment of the rotator cuff before and after surgery. Several classifications have been described aiming to define main tear characteristics. However, there is still confusion when it comes to the reliability of those classifications.
PURPOSE: (1) To identify all MR classifications available in the literature for preoperative assessment of rotator cuff tears, (2) to summarize available data on the reliability of identified classifications, and (3) to assess the methodological quality of reliability studies.
STUDY DESIGN: Systematic review; Level of evidence, 4.
METHODS: This systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. All studies reporting MR assessment in patients with a superior or posterosuperior rotator cuff tear were included. After identification of the available MR criteria, reliability studies were analyzed. Descriptive statistics were used to summarize findings. Methodological quality was assessed using the Quality Appraisal of Reliability Studies checklist.
RESULTS: A total of 75 studies were included in this review. Eight categories of outcomes could be identified. Of the total, 62 studies reported interobserver reliability whereas 32 reported intraobserver reliability of some of the identified criteria. Each category reflected a variety of reliability, ranging from poor to excellent agreement. MR proved to be a reliable imaging modality to detect the structural integrity of the posterosuperior cuff, especially in cases of full-thickness tear; it was also reliable in terms of tear width and length and muscle atrophy based on a tangent sign or Thomazeau classification. All other classifications did not prove acceptable reliability. Methodological quality was high for 23 articles and moderate for 14.
CONCLUSION: Preoperative MR is a reliable imaging modality to identify full-thickness tears, measure tear size and morphology, and identify muscle atrophy with tangent sign or Thomazeau classification. All other outcomes and classifications did not show acceptable reliability; therefore, caution is needed when using them for preoperative evaluation of a rotator cuff tear.
The present invention relates to an edible pumpkin canned food suitable for diabetics, which aims to solve the problems that pumpkin blocks in the existing pumpkin canned food have soft texture, pumpkins are easy to dissolve in water in the can, and the canned food is easily turbid. The present invention is manufactured by that pumpkin blocks after being peeled and diced are soaked by discolor cinquefoil herb water and processed by adding xylose or proteoglycan according to conventional sweet water canned food technology. The discolor cinquefoil herb water is an aseptic edible water solution or a purified water solution in which the discolor cinquefoil herb is soaked. The discolor cinquefoil herb water is the discolor cinquefoil herb water solution which is prepared by a method that 0.5 to 6 wt% of discolor cinquefoil herb is added in 100 portions of water of 70 to 80 DEG C to be soaked for 20 to 60 minutes. The soaking time of the pumpkin blocks in the discolor cinquefoil herb water is 20 to 40 minutes, and the temperature is 70 to 80 DEG C. The pumpkin canned food is suitable for diabetics and also has health care action. The present invention has the advantages of good pumpkin block texture, difficult dissolution and turbidity, high clear degree, good appearance and mouth feeling and long shelf life. The pumpkin canned food is suitable for diabetics as well as for healthy people.
Aims Agonal breathing ("gasping for air") has previously been found to be associated with the outcomes of out-of-hospital cardiac arrest (OHCA) patients on which resuscitation was attempted. On the other hand, little is known, about agonal breathing with regard to whether it is a positive factor for survival after hospital admission and how it relates to the patient's future quality of life. For this reason we have undertaken a retrospective study using a comprehensive emergency medical service (EMS) database from the Central Bohemian region of the Czech Republic. The primary endpoint of the study was to assess if agonal breathing present when EMS arrives has a positive impact on the six-month survival of OHCA patients, which was independent of other factors like EMS response time and BLS provision. The secondary endpoints sought to determine if agonal breathing positively impacts ROSC and an evaluation of various factors that can influence agonal breathing, specifically response time and provision of BLS.

Method The data were recorded using the Utstein protocol. Only anonymized data were used for analysis. The data were derived from the EMS registry of the Central Bohemian Region, which is the largest EMS in the Czech Republic. The study sample included all OHCA cases, of presumed cardiac origin, that where resuscitated by the EMS between 1st July 2013 and 30th June 2014 (n = 584). Two subsequent patient outcomes: (1) return of spontaneous circulation (defined as spontaneous circulation at hospital admission) and (2) six-month survival were assessed in patients with and without agonal breathing. Six-month survival data of OHCA patients of presumed cardiac origin was derived from administrative insurance registries or medical records of patients, with only aggregated data being available.

Factors that may influence the presence of agonal breathing, specifically BLS provision before a professional EMS team reached the patient and second, EMS team response times, were also examined. BLS provision by lay persons was reported by the first-on-scene EMS team as (yes/no) and phone assisted CPR was registered by the dispatcher as (yes/no). BLS was considered to have been provided if any of the following activities (1) resuscitation by a bystander, (2) phone assisted CPR, or (3) both were recorded as having been performed. The response time was calculated as the elapsed time between recorded activation of an EMS team and the on scene arrival time.

Other covariates such as age and sex were also available and analyzed. The initial difference in response time between the groups was assessed using the T-test. For categorical variables, the chi-square test was used. Simple and multivariate logistic regression models were used to assess relationships between factors related to the presence of agonal breathing and ROSC. A p-value of \< 0.05 was considered statistically significant.
Klebsiella pneumoniae is a Gram-negative bacterium associated with a wide range of community- and hospital-acquired infections. The emergence of clonal hypervirulent strains resistant to last-resort antimicrobial agents has become a global concern. The Kingdom of Saudi Arabia (KSA), with its diverse population and high tourism traffic, serves as a platform where the spread of multidrug-resistant (MDR) strains are facilitated. However, the knowledge of epidemiology and population diversity of MDR K. pneumoniae in KSA is scarce. We conducted a comprehensive genomic survey on 352 MDR K. pneumoniae isolates systematically collected from bloodstream and urinary tract infections in 34 hospitals across 15 major cities in KSA during 2022 and 2023. Whole-genome sequencing on the isolates was performed, followed by genomic epidemiology and phylodynamic analysis. Our study revealed a dynamic population characterized by the rapid expansion of several dominant clones, including, ST2096, ST147, and ST231, which were estimated to have emerged within the past decade. These clones exhibited widespread dissemination across hospitals and were genetically linked to global strains, particularly from the Middle East and South Asia. All major clones harboured plasmid-borne ESBLs and carbapenemase genes, with plasmidome analysis identifying multiple IncH, IncA/C and IncL plasmids underlying the MDR-hypervirulent phenotype. These plasmids were shared between major clones and became acquired on the same time scales as the expansion of the dominant clones. Our results report ST2096 as an emerging MDR-hypervirulent clone, emphasizing the need for monitoring of the circulating clones and their plasmid content in the KSA and broader West Asia.
Participants are given quadrivalent live, attenuated influenza vaccine (LAIV4)/ FluMist® . For children requiring 2 doses of vaccine, a second immunization will be given at Day 28-32 after Dose 1. All participants in this group will be asked to return annually for repeat immunization per ACIP guidelines and blood sample collection.