anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The objective of this research project is to map and clone genes that are important for the normal development or maintenance of the auditory system. One strategy for identifying some of the genes important for auditory processes is to ascertain large families each with several hearing impaired individuals. Initial contact will be made by family physicians, audiologist, supervisors in schools for the hearing impaired, and directly by the principal investigators during surveys of schools for the deaf and visits with hearing impairment self-help groups. Members of a family will be evaluated by an audiologist, and instances of hearing impairment will be documented and categorized. A clinician would then examine hearing impaired and unaffected members of the family for the presence of other clinical features so as to distinguish between nonsyndromic and syndromic forms of hearing impairment. Pedigrees of these families will be analyzed to determine the mode of inheritance of the hereditary hearing impairment segregating in each family. Families will be ascertained through audiologists and other clinicians, genetics clinics, schools for the hearing impaired and through linguists and medical anthropologists who study unique sign languages and the sociology of communities with a high proportion of hearing impaired individuals. The mutated gene will then be genetically mapped by a linkage or association based strategy, using DNA typing of highly polymorphic genetic markers distributed across the human genome.
One injection to be administered every 4 weeks up to 6 injections. The dose per injection is 50 kBq/kg body weight (55 kBq/kg after implementation of NIST update).
Participants will receive fenofibrate (FENO) 48 mg tablet orally once daily for 2 weeks in the pretreatment phase, then FIR 20 mg tablet + FENO 48 mg tablet orally once daily for 24 weeks in the treatment phase. Participants with compensated cirrhosis due to NASH will be accepted to participate in this cohort.
In HIV-endemic settings, many HIV-uninfected women choose to conceive with an HIV-infected or unknown-serostatus partner. For a woman who cannot depend on a partner to test, initiate and adhere to ART, sex without condoms puts her at high risk of acquiring HIV and increases the risk of perinatal transmission to her child. Daily, oral TDF/FTC PrEP dramatically reduces a woman's risk of HIV-acquisition and is the only female-controlled option for reducing the risk of periconception HIV-acquisition. Understanding whether daily, oral PrEP is feasible for uninfected women seeking pregnancy is critical to reducing HIV incidence among women and their children.

Placebo-controlled trials identified adherence as a major challenge to long-term PrEP use. However, women are eager for prevention strategies that allow for conception, and we hypothesize that adherence to a proven prevention strategy, for a limited time with the motivation to have a healthy child, will confer drug levels required to prevent HIV transmission. This project will inform whether daily, oral PrEP is a feasible HIV-prevention strategy for South African women who intend to conceive with risky partners. Given the repercussions of acquiring HIV during conception and pregnancy, this is an important step towards providing a key prevention strategy to women and their children.
PURPOSE: It is well known that the coronavirus disease 19 (COVID-19) epidemic had an adverse effect on the health-related quality of life (HRQOL) of patients with disabilities, or neurological or chronic conditions. The aim of this study was to examine the possible factors affecting HRQOL in patients with burn injuries during COVID-19 epidemic.
METHODS: The study included a total of 40 burns patients. The demographic and burn injury information of the patients were recorded. The active range of motion was measured with a goniometer. The HRQOL, community integration, scar tissue quality and anxiety level were evaluated using the Burn-Specific Health Scale (BSHS), the Community Integration Questionnaire Revised (CIQ-R), Patient and Observer Scar Assessment Scale, and the State-Trait Anxiety Inventory, respectively.
RESULTS: The history of COVID-19 infection, total burn surface area (TBSA), community integration level, work-related burns, the presence of trunk burn injury, the presence of face burn injury, and the presence of a major burn injury were determined to be significantly associated with the HRQOL of burns patients (p < 0.05).
CONCLUSION: The history of COVID-19 infection, community integration level, and burn-related parameters (TBSA, localization, severity etc.) were found to be factors associated with the HRQOL during the epidemic. The history of COVID-19 and community integration level should be evaluated in addition to the burn injury parameters to improve the quality of life of burn survivors. It can be recommended that these clinical parameters should be considered when planning the treatment program during and after the epidemic.
High-resolution and high-throughput genotype-to-phenotype studies in fish are rapidly advancing, driven by innovative technologies that aim to address the challenges of modern breeding models. In recent years, machine vision and deep learning techniques, particularly convolutional neural networks (CNNs), have achieved significant success in image recognition and segmentation. Moreover, qualitative and quantitative analysis of disease resistance has always been a crucial field of research in genetics. This motivation has led us to investigate the potential of large yellow croaker visceral white-nodules disease (VWND) in encoding information on disease resistance for the task of accession classification. In this study, we proposed an image segmentation framework for the feature extraction of the spleen after VWND infection based on machine vision. We utilized deep CNNs and threshold segmentation for automatic feature learning and object segmentation. This approach eliminates subjectivity and enhances work efficiency compared to using hand-crafted features. Additionally, we employed spleen-related traits to conduct genome-wide association analysis (GWAS), which led to the identification of 24 significant SNPs and 10 major quantitative trait loci. The results of function enrichment analysis on candidate genes also indicated potential relationships with immune regulation mechanisms. Furthermore, we explored the use of genomic selection (GS) technology for phenotype prediction of extreme individuals, which further supports the predictability of spleen-related phenotypes for VWND resistance in large yellow croakers. Our findings demonstrate that artificial intelligence (AI)-based phenotyping approaches can deliver state-of-the-art performance for genetics research. We hope this work will provide a paradigm for applying deep learning and machine vision to phenotyping in aquaculture species.
Few studies have examined diabetes impact on total joint arthroplasty (TJA) outcomes, with variable findings. We investigated the association between diabetes and post-TJA physical function and pain, examining whether diabetes impact differs by sex and BMI. Patient sample completed questionnaires within 3 months prior to hip or knee TJA for osteoarthritis (OA) and 1-year post-surgery. Surgical 'non-response' was defined as < 30% improvement in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and physical function at 1-year. Two adjusted logistic regression models were estimated: (1) excluding, (2) including an interaction between diabetes, sex and BMI. The sample (626 hip, 754 knee) was 54.9% female, had mean BMI of 30.1, 13.0% reported diabetes. In adjusted models excluding an interaction, diabetes was not associated with non-response. However, a significant 3-way interaction (physical function: p = 0.003; pain: p = 0.006) between diabetes, sex, and BMI was found and was associated with non-response: non-response probability increased with increasing BMI in men with diabetes, but decreased with increasing BMI in women in diabetes. Findings suggest uncertainty in diabetes impact may be due to differential impacts by sex and BMI. A simple consideration of diabetes as present vs. absent may not be sufficient, with implications for the large TJA population.
Subjects were primed with 3 doses of ActHIB co-administered with Pediarix and boosted with 1 dose of PedvaxHIB, with co-administration of M-M-R II and Varivax. Subjects received vaccination at approximately 2, 4, 6 months and the fourth dose at 12-15 months of age. ActHIB, PedvaxHIB vaccines were administered intramuscularly in the right upper thigh and Pediarix vaccine in the left upper thigh. M-M-R II and Varivax vaccines were administered subcutaneously respectively in the upper left arm and the upper right arm.
The 12-week program included a 60-minute session. Participants filled out a Physical Activity Readiness Questionnaire and completed pre-exercise fitness tests. The fitness tests included the curl up, pushup, and a 1.5 mile walk test. The session involved a warmup which included stretching followed by a 5-min walk for a total of 10 minutes. Functional bodyweight and resistance training exercises were implemented and supervised by the principal investigator (PI) who specializes in program design and implementation. The exercises targets major muscle groups such as legs, chest, back, and shoulders. The resistance training portion took 30-35 minutes. Steady-state aerobic activity which included walking took place at the end of the session for 10-15 minutes. The intensity was monitored using self-rated RPE scores which participants would report to the PI following each session.
Described herein are methods for preventing a relapse of cancer in a subject. The methods involve administering to the subject in need thereof a sulfated glycosaminoglycan or the pharmaceutically acceptable salt or ester thereof. In one aspect, the methods described herein prevent the growth or self-renewal of cancer stem cells in a subject. In another aspect, the methods described herein kill active or dormant cancer stem cells in a subject. The methods described herein can be used in combination with chemotherapy and/or radiation. The methods described herein are versatile with respect to preventing the relapse of a number of different cancers.
PROBLEM TO BE SOLVED: To obtain the subject composition to be used through applying onto the coating surface of bonding material cured products so as to prevent the adhesion of the coating surface to an instantaneously polymerized resin and be easily removable thereafter by including a polymerization inhibitor and a water-soluble polymer. SOLUTION: This composition is obtained by including (A) a polymerization inhibitor (e.g. 2,6-t-butylcresol) and (B) a water-soluble polymer with a weight- average molecular weight of pref. 100-2,000,000, esp. 300-1,500,000 (e.g. polyethylene glycol), and (C) as necessary, water and/or a water-miscible organic solvent (e.g. ethyl alcohol); wherein the amount of the component A to be formulated is pref. 3-50 (more pref. 5-30) wt.% based on the total weight of the components A to C; when the component is used, it is preferable that this composition is in the form of a uniform solution and its viscosity being 10-100 p.
Subjects will immediately be prepared for a casting of their residual limb. On the second visit, subjects will return to be fitted with a definitive rigid carbon fiber socket. At this time, a questionnaire and physical assessments will determine subjects comfort and safety. The physical assessment consists of a ten minute walk on a treadmill, at a self-selected pace. A balancing test on a SMART Balance Master will also be used to assess subject safety, by utilizing the limits of stability protocol. Subjects' will be required to wear the prosthesis given to them for one week before returning for a follow-up appointment. On the third visit, the subjects' will return the first prosthesis to the investigators of the study, where an additional socket will be given to the subject for the second portion of this study. Subjects will be evaluated with a questionnaire and physical assessments to determine comfort and safety. Participants will be required to wear the prosthesis given to them for one week before returning for a follow-up appointment. During the final appointment, the subjects will return all devices given to them to an investigator of the study.
BACKGROUND: Patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with radiation-based therapy suffer from short- and long-term toxicities that affect quality of life (QOL). Transoral robotic surgery (TORS) has an established role in the management of early OPSCC but adjuvant treatment is often indicated postoperatively due to the high incidence of nodal metastasis associated with advanced human papillomavirus (HPV)-related OPSCC. To overcome the need for adjuvant radiation therapy (RT), neoadjuvant chemotherapy followed by TORS and neck dissection (ND) is proposed. This study aimed to assess if QOL in HPV-associated OPSCC receiving neoadjuvant chemotherapy followed by TORS and ND returns to baseline within 12 months of completing treatment.
METHODS: A 12 month longitudinal study was carried out at McGill University Health Centre in Montreal, Canada, among a convenience sample of patients with American Joint Committee on Cancer Seventh Edition stage III and IVa HPV-related OPSCC who were treated with neoadjuvant chemotherapy followed by TORS and ND. QOL data were obtained pretreatment and at 1, 3, 6, and 12 months following treatment completion using the European Organisation for Research and Treatment of Cancer Core and Head and Neck extension modules. Paired t tests and mixed models for repeated measures analysis were used to assess changes in QOL from baseline to 12 months postoperatively and over time, respectively.
RESULTS: Nineteen of 23 patients (median age 58 years) who received the study treatment fulfilled the eligibility criteria. OPSCC subsites were palatine tonsil (n = 12) and base of tongue (n = 7). All 19 patients were treated per protocol and none required adjuvant RT as per pathology review and protocol requirements at a postoperative multidisciplinary team tumor board discussion. No significant differences were found when comparing 12 month QOL follow-up scores to pretreatment scores in measures that would likely be affected by RT [eg, swallowing (P = .7), social eating (P = .8), xerostomia (P = .9)].
CONCLUSION: In HPV-related OPSCC, neoadjuvant chemotherapy followed by TORS and ND as definitive treatment is associated with excellent QOL outcomes. Postoperative QOL scores returned to baseline by 3 months and were maintained for all measures, indicating a return to normal function.
Veterans Health Administration (VHA) patients are at a significantly elevated risk for fatal and non-fatal suicide attempts and identifying strategies to reduce the risk of suicidal behavior among members of the military and Veterans is a high national priority. The VHA has invested extensively in suicide prevention and, as part of these efforts; the Veterans Crisis Line was developed as an important resource for Veterans and their families. Utilization of the Veterans Crisis Line has expanded steadily since it first opened and, currently, it receives over 20,000 calls per month. Despite high utilization of the Crisis Line, no data are currently available on whether use of the Veterans Crisis Line reduces an individual's likelihood of a suicide attempt or death and it is not feasible to test the efficacy of the Crisis Line in a randomized controlled trial because it is nationally available to all Veterans and their families. More importantly, the Veterans Crisis Line may not reach those individuals at most acute risk for suicide. The investigators' study team conducted a small survey of Veterans treated for recent suicidal crisis in a VHA inpatient psychiatric unit and found that less than half had ever utilized the Veterans Crisis Line and less than a third had used it within the past year. Consequently, the investigators have developed and gathered pilot data on a brief intervention designed to increase utilization of the Veterans Crisis Line among high risk patients, called Crisis Line Facilitation (CLF). This single-session intervention involves a discussion of the patient's perceived barriers of crisis line use during periods of suicidal crisis. The CLF session ends with the patient calling the Crisis Line with the therapist in the room as a way for Veterans to practice the logistics of making the call and to have direct experiences that may counter any negative beliefs about Veterans Crisis Line use. This study recruited 301 participants who were treated for a suicidal crisis in VHA inpatient psychiatric but had not recently used the Veterans Crisis Line. This study is a randomized controlled trial of the impact of CLF compared to enhanced usual care (EUC) on utilization of the Veterans Crisis Line and other mental health services as well as suicide attempt(s). All participants will be re-assessed at 3-, 6- and 12-months post baseline. Analyses will also examine the extent to which post-baseline Crisis Line use mediates the effect of random assignment to CLF on subsequent suicidal behaviors. Qualitative interviews at the end of the study will help understand barriers and facilitators of future implementation of the CLF intervention. If successful, the proposed study will provide key data on the potential efficacy of a brief intervention to improve the utilization of an existing resource, the Veterans Crisis Line, to reduce suicidal behaviors in VHA patients. Developing a brief and effective approach to encourage use of the Crisis Line has the potential to have a significant and substantial impact on suicide rates within the VHA and could be modified and exported to other populations and settings.
Prepn. of immunogenic agents against swine fever and vaccines containing them, comprises inactivation of cultures of swin fever pathogenic virus using an alkylating agent. The nature and concn. of the agent are chosen so that the kinetics of the inactivation reaction can be controlled and inactivation may be completed without causing denaturation of the virus; the inactivation reaction is then stopped by neutralising the excess alkylating agent. The use of an inactivated virus avoids the risks of development of modified strains of the virus, which may occur when living virus vaccines are used. The process leads to an effective vaccine, free from all pathogenic risk and having well defined, reproducible characteristics. The pref. virus used is known as A-19 isolated by Laboratoire Central de Recherches Veterinaires at Maisons-Alfort.
A therapeutic preparation for the treatment of mental diseases comprises 2-amino-1,3,3-tricyano-2-propene dispersed in or dissolved in a pharmaceutically acceptable carrier.  The preparations are preferably administered in unit dosage forms such as tablets, capsules, pills, powders, packets, granules, wafers, cachets, sterile parenteral solutions or suspensions, or oral solutions or suspensions.  For solid compositions e.g. tablets, adjuvants such as corn starch, lactose, sucrose, sorbitol, talc, stearic acid, magnesium stearate, dicalcium phosphate or gums are used.  The tablets or pills may be laminated, the inner dosage component being separated from the outer by an enteric layer consisting of materials such as polymeric acids or mixtures of polymeric acids with shellac, shellac and cetyl alcohol or cellulose acetate.  A particularly useful enteric layer contains styrene maleic acid copolymer with other known enteric materials. Specified liquid forms are aqueous solutions, flavoured syrups, aqueous or oil suspensions, flavoured emulsions with edible oils such as cottonseed, sesame, coconut or peanut oil and elixirs. Suitable suspending agents for aqueous suspensions are synthetic or natural gums, e.g. tragacanth, acacia, alginate, dextran, sodium carboxy methyl cellulose, methyl cellulose, polyvinyl pyrrolidone or gelatine.  In aqueous preparations antioxidants may be included, e.g. 0.1% ascorbic acid or 0.1% of a sulphur containing reducing agent, e.g. sulphur dioxide, sulphur containing acids which may yield sulphur dioxide, soluble non-toxic salts of such sulphur containing acids or aldehyde addition products thereof.  The preparations may contain other medicaments such as tranquilizers, e.g. reserpine, chlorpromazine, promethazine benactyzine, ectylurea, imipramine, or meprobamate; sedatives, e.g. phenobarbital, pentobarbital or amobarbital; analgesics, e.g. aspirin, phenacetin, salicylamide or N-acetyl-p-aminophenol; stimulants, e.g. amphetamine, cleanol, pipradol, methyl phenidyl or improniazed; Vitamins A1, D1 B,1, B2, B6, B12, pantothenate, folic acid or nicotinamide; and hormones e.g. oestradiol or methyl testosterone.  The therapeutic compositions may contain 25 to 3000 mg. per unit dose of the principal active ingredient and preferably 125 to 500 mg.  Addititional ingredients are calcium stearate, mineral oil, methyl and propyl paraben, sodium saccharin, sodium cyclamate, glycerine, orange and cherry flavours, orange and red dyes, alcohol, propylene glycol, sodium metabisulphite, sodium bisulphite, chlorobutanol or aluminium stearate.
An externally applied plant composition having a whitening effect, an externally applied plant extract composition prepared from the plant composition, an externally applied skincare composition preparation prepared from the plant composition, and preparing methods of the plant extract composition and the skincare composition preparation are provided. The externally applied plant composition comprises following raw material medicines by weight: 10-40 parts of reed rhizome, 10-40 parts of liquorice root, 10-40 parts of Chinese angelica, 10-40 parts of danshen root, 10-40 parts of asiatic cornelian cherry fruit and 10-40 parts of Chinese wolfberry root-bark. The compositions and the preparation are proved to be safe and nonirritant to skin and to have effective whitening effects. Raw materials are easily available. The preparing methods are simple and convenient. The compositions and the preparation are green, safe, and easily acceptable by persons and have good application prospects and market prospects.
The present invention discloses hypnotic body-building bath lotion for hypnotism. The present invention uses high concentration distillation grain spirit raw juice which is not mixed is used as a solvent. Various traditional Chinese medicine solutes having the functions of heart nourishing, tranquilization, yin nourishing, blood nourishing, dysthesia elimination, etc. are selected to be prepared in certain proportion to obtain the hypnotic body-building bath lotion. The present invention also discloses a method for preparing the hypnotic body-building bath lotion. The present invention provides a new approach for treating insomnia and various pathological forms which are caused by the insomnia.