anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The prevalence of cardiovascular disease (CVD) has surged in recent years, making it the foremost cause of mortality among humans. The Electrocardiogram (ECG), being one of the pivotal diagnostic tools for cardiovascular diseases, is increasingly gaining prominence in the field of machine learning. However, prevailing neural network models frequently disregard the spatial dimension features inherent in ECG signals. In this paper, we propose an ECG autoencoder network architecture incorporating low-rank attention (LRA-autoencoder). It is designed to capture potential spatial features of ECG signals by interpreting the signals from a spatial perspective and extracting correlations between different signal points. Additionally, the low-rank attention block (LRA-block) obtains spatial features of electrocardiogram signals through singular value decomposition, and then assigns these spatial features as weights to the electrocardiogram signals, thereby enhancing the differentiation of features among different categories. Finally, we utilize the ResNet-18 network classifier to assess the performance of the LRA-autoencoder on both the MIT-BIH Arrhythmia and PhysioNet Challenge 2017 datasets. The experimental results reveal that the proposed method demonstrates superior classification performance. The mean accuracy on the MIT-BIH Arrhythmia dataset is as high as 0.997, and the mean accuracy and F 1  -score on the PhysioNet Challenge 2017 dataset are 0.850 and 0.843.
The invention belongs to the technical field of medicines and particularly relates to a self-microemulsifying soft capsule content combination of ciclosporin A. The self-microemulsifying soft capsule content combination of ciclosporin A comprises 1-12 parts of ciclosporin A, 1-12 parts of phosphatidylcholine, 5-20 parts of anhydrous ethanol, 5-20 parts of propylene glycol, 30-80 parts of polyoxyethylene hydrogenated castor oil, 5-30 parts of span 80 and 10-30 parts of medium-chain triglycerides. The invention further provides a preparation method of the self-microemulsifying soft capsule content combination of ciclosporin A. The raw materials selected by the invention are easily available and low in cost, and the preparation process is simple, so that the self-microemulsifying soft capsule content combination of ciclosporin A is suitable for large-scaled industrialized production. The bad character that ciclosporin A is low in bioavailability can be overcome and the disparity of bioavailability of individuals can be reduced as far as possible. Dissolubility of water insoluble medicines is greatly improved, and the bioavailability of the medicines is improved. Particularly, combination with phosphatidylcholine increases the clinical curative effect of ciclosporin and reduces severe side effects of renal toxicity and hepatotoxicity in clinical application of ciclosporin.
Placebo oral capsules administered once daily. Double dummy used for blinding i.e. 2 x 50mg size + 1 x 200mg size placebo capsules equal in total 3 capsules administered daily.
Consecutive patients aged 16 years and over, who had exhausted conservative treatment and subsequently underwent primary correction of hallux valgus (of any deformity severity) were included. Patients who underwent additional forefoot procedures eg. hammer toe corrections, distal metaphyseal metatarsal osteotomy, were included. Patients who had previously had hallux valgus surgery, or first ray degenerative joint disease were excluded.
It has been repeatedly demonstrated that African-American renal allograft recipients have worse graft outcomes when compared with Caucasians. This has been attributed to various immunologic and non-immunologic factors, including a greater rate of acute rejection, resistance to standard doses of calcineurin inhibitors (CNIs) and corticosteroids, different pharmacokinetic and pharmacodynamic profiles, and noncompliance. It has therefore been suggested that quadruple immunosuppression, including antilymphocyte antibodies for induction, should be used in this high-risk population to improve graft survival. CNIs are currently the mainstay of immunosuppressive regimens. Tacrolimus has been shown to be significantly more effective than Cyclosporine A in preventing acute rejection. As a result, Tacrolimus has become the CNI of choice in preventing acute rejection, and has produced similar graft survival rates at one year, with higher creatinine clearances. However, there is no report examining the efficacy of Sirolimus in improving renal function and its side effect profile when compared with Tacrolimus in renal allograft recipients, particularly in African-Americans with immediate graft function in a steroid-free environment.
Cigarette smoking is the most significant preventable cause of death and disease, causing 6 million deaths annually worldwide. Despite the fact that tobacco use in Hong Kong has been decreased from 23.3% in 1982 to 10.1% in 2017, the remaining 620 600 daily smokers\[3\] cannot be overlooked or undervalued.

Hong Kong is a predominantly Chinese society, but it has a sizeable South Asian ethnic minority (EM). According to the Census \& Statistics Department, the number of ethnic minorities in Hong Kong increased significantly by 70.8% over the past 10 years. Nevertheless, few smoking and health promotion activities and smoking cessation services have been tailor-made for ethnic minorities in Hong Kong. The barrier of supplying smoking cessation service to the ethnic minority group is that their smoking motivation, willingness to quit, obstacles of quit smoking, attitude towards Hong Kong tobacco law and smoking cessation services are not sure. This will be the first research exploring their knowledge, attitude and experience of cigarette smoking.
Spinal anesthesia was administered to the patients for anesthetic support of the surgical intervention.Intrathecal injections were performed with a 24G or 25G "Pencil point" needle in the L3-L4 interval. Spinal puncture was performed while the patient was sitting on the table.Spinal anesthesia was performed with 3 ml of 0.5% bupivacaine. Then the patient was placed on his back.Surgery was allowed to start after 40 minutes if the upper level of the sensory block reached the Th10 segment.
Patients who exhibit a lung lesion with size and location amenable to SBRT receive pembrolizumab IV on day 1 and SBRT on days 44-47 or IMRT, PBT, or 3D-CRT on days 43-61. Treatment with pembrolizumab repeats every 21 days for up to 16 courses in the absence of disease progression or unacceptable toxicity.
PURPOSE:To obtain the titled essence consisting essentially of saccharides and amino acids advantegeously, by hydrolyzing powder of coix seed with hydrochloric acid, reacting the hydrolyzate with trichlorofluoroethane, followed by concentrating the top layer part and the middle layer part of the divided three parts under reduced pressure. CONSTITUTION:Powder of coix seed is hydrolyzed with ten times amount of 2N hydrochloric acid. The prepared muddy substance is stirred with the same amount of trichlorotrifluoroethane and allowed to stand so that the solution is separated into three layers. The top layer and the middle layer are concentrated under reduced pressure, to give an essence obtained by hydrolysis of coix seed useful as an improved humectant. The blend of it and a cosmetic prevents the dryness of the skin and hair, and provides softness. The blend has tyrosinase inhibiting actions, and prevents the formation of melanine. When the bottom layer of the divided three layers is concentrated under reduced pressure, a liquid oil consisting essentially of free fatty acis is obtained. This oil is not viscous and has no tackiness, its application to the skin and hair provides gloss.
PURPOSE: A radiation inducible cyoA promoter is provided to promote an anticancer protein and to effectively treat cancer. CONSTITUTION: A radiation inducible cyoA promoter contains a base sequence of sequence number 1. The promoter is derived from Salmonella typhimurium. An expresion vector contains the promoter. A gene construct has the promoter which is operately linked to a gene encoding foreign proteins. A composition for preventing and treating cancer contains the recombinant vector or cells which is transformed by the recombinant vector.
Title: A prospective, multicenter, single-arm clinical trial to evaluate the safety and efficacy of pEGASUS stent system for assisted endovascular treatment of intracranial aneurysms Device: pEGASUS stent system Design: Prospective, Multicenter, Single Arm Clinical Study. Purpose: To assess safety and effectiveness of the pEGASUS stent system. Study duration: 31 months. Sample Size: 130 patients. Number of sites: ≤10. Follow-up time: 12 months.
Breast cancer (BCa) is a prevalent form of cancer in women, exhibiting varying rates and distribution across different ethnic groups. Among these groups, African American (AA) women have the highest incidence of BCa and the lowest levels of Vitamin D (VD). Numerous studies have explored the connection between variations in the VDR gene and BCa risk, particularly in different populations, but research on the AA population remains limited. Epigenetic modifications, including specific microRNAs (miRNAs), can influence gene expression without altering the genetic code and have been implicated in cancer initiation and progression. Our hypothesis suggests that VDR gene variations may increase BCa risk in AA women and that changes in miRNA expression profiles could contribute to BCa development. Using data from the 1000 Genome Project, we identified five VDR gene variants with significant frequency differences between AA and European-American (EA) populations. We genotyped 404 African American BCa cases and controls for five variants using TaqMan® assays. SNPstats assessed their association with BCa risk. The rs1544410 variant's recessive model (A/A) showed a decreased BCa risk in AA (odds ratio 0.33, 95% CI: 0.15-0.73, p-value 0.0041). Conversely, the rs2853563 variant's recessive model (A/A) was linked to an increased BCa risk (odds ratio 4.04, 95% CI: 1.49-10.95, p-value 0.0022). We investigated miRNA expression influenced by VD in HCC1806 Triple-Negative Breast Cancer (TNBC) cell lines with the A/A allele for rs2853563. nCounter® Nanostring technology assessed miRNA profiles after calcitriol treatment. Our results indicated that calcitriol treatment led to reduced expression of six miRNAs, four of which are associated with tumor suppression in the presence of the AA genotype in TNBC cell lines. These findings suggest that specific VDR genotypes could have a potential effect on the miRNAs expression which could potentially serve as markers for cell proliferation in TNBC.
Efficacious hypertension therapies are well-documented, yet 40% of treated patients do not meet the blood pressure goals set by the Joint National Committee. This gap between scientific evidence and clinical outcomes in part reflects low patient adherence to lifestyle recommendations (e.g., physical activity, weight and diet), as well as medication non-adherence. Accordingly, growing attention is focused on the need to provide patients with effective self-management support tools. In addition to finding ways to help patients adhere to currently prescribed hypertension care, it is useful to consider the range of treatment options that are offered. Evidence-based reviews have identified stress reduction as an effective tool for reducing blood pressure, yet such approaches are typically not implemented in practice. This omission represents a chance to improve the quality of hypertension care by adding stress management self-management tools. Furthermore, since patients have demonstrated a clear interest in mindfulness, the incorporation of a holistic mind-body intervention is an innovative approach to inherently patient-centered care. Increasing data supports the use of mindfulness for treating health concerns. Its holistic nature may be particularly well-suited to developing and maintaining healthy lifestyles, since lifestyle impacts diverse aspects of physical and psychological health. Yet the potential for mindfulness in health self-management has not been realized.

Limited but promising data demonstrate the effectiveness of web-based counseling for behavior modification to improve common chronic disease risk factors. It is an ideal solution to provider time constraints and a potential solution to patient non-adherence to lifestyle recommendations. Health information technology provides a way to make self-management support affordable, convenient and feasible. The investigators have developed a convenient behavioral self-management support platform, "Goal-oriented Online Access to Lifestyle Support" (GOALS) for primary care patients, which has promoted weight loss and improved blood pressure control among primary care patients with weight-related cardiovascular risk factors. To maximize the ability of patients to achieve blood pressure goals, the investigators propose to add an online mind-body-behavior program to GOALS: "Minding GOALS." The investigators will evaluate the feasibility of using this program for self-management support, in coordination with primary care, in a group of 76 patients with uncontrolled hypertension. In preparation for a randomized clinical trial comparing the online tool to online traditional self-management support, the investigators will assess implementation and determine 1) the availability of eligible and willing subjects using the proposed recruitment methods, 2) the feasibility of delivering the proposed interventions in the population of interest, and 3) the viability of the proposed measurement protocols.
Edentulism is prevalent in elderly people and the current care is the use of removable denture based on edentulous jaw regions. Nevertheless, the close and extended contact of denture base with mucosa and the transmission of chewing movement trough the complete denture leads to a weakening of supporting tissues in the medium to long term. This embrittlement may be accompanied by pain, compromising the proper integration of complete denture. In geriatrics, the peculiar weakness of bearing surfaces, connected to physio-pathological conditions as well as the decrease of adaptability and resistance further complicate the biomechanical integration of this kind of prosthesis. It has been shown that chronical ageing induces a decrease of resiliency and hydration of oral mucosa, associated with a decrease of epithelium thickness; nevertheless few studies have been performed at the molecular and supramolecular level to characterize this mucosa. Techniques of material characterization (Fourier transform Infrared spectroscopy, Differential scanning calorimetry (DSC), Thermostimulated currents (TSC), have shown their ability to follow hydric, molecular and structural modification of dermis upon ageing. In accordance with this study, the distribution of thermal, vibrational and dielectric markers of oral mucosa will be extracted in two age groups. The principal hypothesis of the research is the possibility to identify specific markers and to follow molecular and organizational changes induced by ageing (intrinsic ageing or extrinsic ageing due to prostheses wearing). The characterization of saliva by Fourier transform infrared spectroscopy (FTIR) shows promise in quantifying the biochemical components of this biofluid. Some vibrational saliva biomarkers have high diagnostic potential (physiological stress, diabetes, salivary lithiasis, carcinomas, periodontitis).This study is a first step to redefine the specification for the most appropriate biomaterial in removable prostheses.
The investigator propses a 23-week prospective, open label, single center, environmental remediation intervention study in 5-16 year old children with poor asthma control. At visit 1, wristbands will be dispensed and collected to estimate exposure to a suite of common organic contaminants including phthalates, organophosphate esters, several pesticides and polyaromatic hydrocarbons (PAH). During the initial home visit, the Healthy Homes Housing Specialist will conduct an environmental home assessment to identify asthma triggers in accordance with the EPA's recommendations for helping children with asthma. The Housing Specialist will follow the EPA document Home Characteristics and Asthma Triggers, and will provide the family with a Breathe Easy at Home Kit. The Specialist will provide training and instructions on how to use each of the supplies provided in the kit. If the Housing Specialist identifies necessary home repairs during the assessment process, the Housing Specialist can refer the family to organizations that offer home repairs, modifications, and weatherization services. The specialist will discuss the importance of clean air for maintaining lung health for all family members and will discuss the importance of banning of any indoor smoking, smoking anywhere around the household and smoking in any household automobiles (even when the child is not present). Follow up phone calls will be conducted to answer questions, complete questionnaires and complete a household environmental interview.
PURPOSE:The titled remedy having protecting actions on cells in the tissue of an organism, containing a specific prostaglandin analog compound such as 15- cyclobutyl-16,17,18,19,20-pentanoyl-6-oxo-prostaglandin E1, etc. as an active ingredient. CONSTITUTION:A remdy for cell disorder containing a prostaglandin analog compound shown by the formulaI(R<1> is H or 1-12 C alky; R2 is H or 1-6 C alkyl; n is interger of 3-5) or formula II (...X-Y-Z- is a group shown by the formula III, formula IV, formula V, etc.; the coordinations of 5-position and 6- position are S-coordination, R-coordination or their mixture when it is the group shown by the formula IV, etc., and the double bonds of the 5-position and 6-position are E-coordination, Z-coordination or their mixture when it is the group shown by the formula V, etc.), or a nontoxic salt of its acid when R<1> is H, or its cyclodextrin inclusion compound as an active ingredient. The remedy is effective for remedying hepatic diseases, pancreatic diseases, urinary diseases, etc. resulting from cell disorder.
Participants with TNBC-positive metastatic breast cancer in the immunotherapy run-in group (cNTBC) will receive pembrolizumab 200mg IV on day 1 of the first 21-day treatment cycle. nab-paclitaxel 100 mg/m2 on days 1 and 8 of the first 21-day cycle. On the second 21-day cycle, the participants will receive nab-paclitaxel 100 mg/m2 on days 1 and 8 of the cycle, in addition to pembrolizumab 200mg IV on day 1 of the cycle.
Topical hydroalcoholic pharmaceutical composition for treatment of otitis externa and corresponding method and use. Hydroalcoholic pharmaceutical composition, for topical use, with a water concentration comprised between 20% and 40% by weight with respect to the total weight of the composition, and with a concentration of a surfactant comprised between 0.5% and 4% by weight with respect to the total weight of the composition. It is suitable for the prevention and/or treatment of otitis externa. The alcoholic fraction is preferably between 60% and 80% by weight with respect to the final composition. The method for preparing the composition comprises mixing the alcohol, the surfactant and the water at a temperature comprised between 20ºC and 35ºC and an agitation between 2,500 rpm and 3,500 rpm. (Machine-translation by Google Translate, not legally binding)
The invention relates to traditional Chinese medicine gecko-antler powder for treating impotence. The traditional Chinese medicine gecko-antler powder is mainly used for solving the problem that the current drugs for treating impotence are poor in treatment effect and have side effects. The traditional Chinese medicine gecko-antler powder is prepared through the steps of preparing 2 pairs of gecko (the head, feet and black skin are removed), 20g of antler, 10g of prepared rehmannia root and 20g of schisandra fruit, baking, grinding into fine powder, and sieving. The usage and dosage are as follows: the powder is orally taken by 10g once every day and is orally taken with a yellow wine before sleeping. The traditional Chinese medicine gecko-antler powder has the aims and advantages that the total effective rate for impotence treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine gecko-antler powder is free from toxic and side effects.
This study will evaluate the clinical efficacy and safety of the BTL-899M device for changes in muscular system function through muscle strength measurement by hand-held dynamometer. The study is a prospective, multi-center, open-label, single-arm study. The subjects will be enrolled and assigned to two groups - active and sham in a 3:1 ratio. All patients will be required to complete four (4) treatment visits receiving the treatment with the study device and two follow-up visits at 1 month and 3 months. The sham group will be treated with 5% of both energies only. The treatment administration phase will consist of four (4) treatments, delivered 5-10 days apart. The applicators of BTL-899M will be applied over the designated area. The device will induce visible muscle contractions along with heating by radiofrequency (RF). Each therapy session will last 30 minutes. At baseline, after the last treatment, and all follow-up visits, the strength measurement of the treated area will be performed by hand-held dynamometer in all subjects. At the last therapy visit, the patients will receive the Subject Satisfaction Questionnaire and Therapy Comfort Questionnaire to fill in. Subject satisfaction questionnaire will be given to the subjects at all follow-up visits. Safety measures will include documentation of adverse events (AE), which will be assessed after each procedure and at all follow-up visits. During the post-procedure visits (at 1-month and 3-month follow-up visits), all subjects will receive the Lifestyle Change Questionnaire to fill in.
Guardians of hospitalized children will receive the study intervention, viewing a 3 minute educational video about the importance of secure firearm storage from the Be SMART program. Additionally, a cable gun lock will be offered to families in the intervention group along with a Frequently Asked Questions handout from Be SMART.
PURPOSE: Non-alcoholic fatty liver disease (NAFLD), now termed metabolic dysfunction-associated fatty liver disease (MAFLD), is a growing health concern associated with obesity and type 2 diabetes. Bariatric surgery offers potential benefits, but its impact on MAFLD remains incompletely understood, with scarce long-term follow-up prospective studies. Moreover, being liver biopsy the gold standard for liver condition measurement, the need for non-invasive techniques that allow the assessment of MAFLD development after bariatric surgery is imperative. OWLiver® Care and OWLiver® represent two serum lipidomic tests, featuring panels comprising 11 and 20 triglycerides, respectively.
MATERIALS AND METHODS: We conducted a prospective study involving 80 Caucasians to assess the effects of bariatric surgery on MAFLD using non-invasive diagnostics and to identify baseline predictors of MAFLD remission. Serum samples were collected before surgery and at a 3-year follow-up.
RESULTS: After 3 years, the proportion of patients exhibiting a healthy liver escalated from 5.0% at baseline to 26.3%. Conversely, the percentage of steatohepatitis declined from 35.1% to a mere 7.6%. Younger age, female gender, and the absence of type 2 diabetes were associated with MAFLD remission. However, age stood as the only independent variable associated with this favorable liver evolution (R2 = 0.112).
CONCLUSION: Bariatric surgery demonstrates mid-term benefits in improving MAFLD, with younger age as a baseline predictor of remission. Non-invasive diagnostic methods, like OWLiver®, are valuable tools for monitoring MAFLD evolution. Further research with larger populations and longer follow-up periods is warranted to refine personalized treatment approaches.