anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Metal parts in orthodontic and pedodontic fittings are coated with a scratch-resistant flexible coating which will blend in colour with natural teeth, the material used for the coating being non-toxic and not affected by acids in the mouth.  Braces and bands used for straightening children's teeth, and crowns, e.g. of stainless steel, may be coated (e.g. by spraying, dipping or brushing) with a stoving enamel comprising epoxy resin and urea-formaldehyde resin, and heated.ALSO:Metal parts in orthodontic and pedodontic fittings are coated with a scratch-resistant flexible coating which will blend in colour with natural teeth, the material used for the coating being non-toxic and not affected by acids in the mouth.  Braces and bands used for straightening children's teeth, and crowns e.g. of stainless steel, may be coated (e.g. by spraying, dipping or brushing) with a stoving enamel comprising epoxy resin and urea-formaldehyde resin and heated.
Autologous bone marrow derived stem cells have a promising potential in regenerative medicine. In particular the past decade has garnered a great interest in cellular therapy for treating Type2 diabetes mellitus. The pertinent questions in regenerative medicine today are to know about the homing, survival, differentiation and functionality of the cells and based on these to find out the adequate administration methods and choose the optimal dose and cell types. Various modalities have been used in the preclinical and clinical trials. These include MRI,optical imaging in the form of bioluminescence and fluorescence, quantum dots, SPECT and PET/CT imaging. However the methods which are suitable for stem cell tracking in small animals are not easily translated for human trials. In humans PET/CT imaging with its reasonable resolution and unique ability to combine anatomical and functional imaging is considered to be the best bet yet. Hence we intend to label the autologous bone marrow derived stem cells with PET tracer F18-FDG and carry out biodistribution studies, our ultimate aim being to study how in vivo distribution of the cells affect therapeutic efficacy.
Treatment options for symptomatic cartilage loss in the ankle are not consistently effective. This study documents initial outcomes for patients undergoing bipolar OCAT in the ankle after advances in tissue preservation, transplantation techniques, and patient management strategies were implemented. Patients were prospectively enrolled into a registry designed to follow outcomes after OCAT in the ankle. Fourteen patients were included for analyses (12 primary OCAT, 2 revision OCAT). Four patients underwent Bipolar OCAT (tibia, talus) and 10 Bipolar+ OCAT (tibia, talus, fibula). Short-term (median follow-up 43, range 13-73 months) success was documented for 13 patients. Radiographic assessments indicated OCA integration and maintenance of joint space in 12 patients. Statistically significant (p < .030) and clinically meaningful improvements in AAOS and VAS pain scores were noted at 3 months, 6 months, 1 year, and 2 years following OCA transplantation when compared to preoperative measures. For patients that were nonadherent to postoperative restriction and rehabilitation protocols, all 1-year postoperative PROs were significantly lower (p < .050) than for patients who were adherent. The successful outcomes documented in 13 of 14 patients in conjunction with significant and clinically meaningful improvements in patient-reported measures of pain and function support OCA transplantation as an appropriate treatment option in indicated patients. These improvements in outcomes were associated with advances in OCA preservation, preimplantation treatment, transplantation techniques, and patient management strategies, suggesting this shift in practice be considered for OCA transplantation in the ankle.
For group 1, participants do not have intervention as groups 2 and 3. This group consists of reviewing the medical history of the year 2000 to determine the variables of the study and then compare them with groups 2 and 3. This group of participants they were from the year 2000 and whose information will be strictly taken from their medical history was based on initial training with warm-up and walking, after that, aerobic training was performed from 50 to 70% of their maximum heart rate and they finished their session training with breathing exercises, coordination, balance and walking.
We aim to share our experience of the removal of cranio-orbital lesions (COLs) and propose a novel classification to guide the tailored approach selection. We retrospectively reviewed 45 consecutive patients with COLs who underwent surgery performed by the same neurosurgeon between November 2010 and November 2022. The surgical approach was selected according to the anatomical region classification of the COLs. For lesions limited to space A (lateral superior orbital fissure, SOF), the pterion or extended pterion approach (PA or EPA) was used. For lesions limited to space B (extraconal compartment medial SOF, and cavernous sinus CS) and C (intraconal compartment, medial SOF, and CS), the pretemporal transcavernous approach (PTCA) was used. For lesions limited to space D (intraconal compartment and optic canals), the subfrontal approach (SA) was used. For lesions extending into the infratemporal fossa (ITF), the cranio-orbito-zygomatic approach (COZA) was used. For lesions involving pterygopalatine fossa (PPF), the endoscopic transnasal approach (ETNA) was used. We analyzed the clinical manifestations, imaging data, surgical approaches, surgical outcomes, neurological outcomes, and follow-up data. Gross total resection was performed in 35 patients (35/45, 77.8%). SA, PA, EPA, PTCA, COZA, and ETNA were performed in 9, 9, 10, 10, 6, and 1 case(s), respectively. Progression of the residual tumor was observed in 6 cases (1 adenoid cystic carcinoma and 5 meningiomas). Surgical approach selection plays a vital role in patient prognosis. This novel classification based on the involvement of anatomic space could help surgeons select an appropriate approach to remove the COLs.
Participants will receive weekly injections of 180 mcg PEG-IFN alfa-2a at the clinic for 12 weeks. After Week 12, participants will be followed off-treatment until Week 18.
<P>PROBLEM TO BE SOLVED: To provide a method for production related to a substance containing citrus fruit pericarp.  <P>SOLUTION: Each site such as exocarp, mesocarp, endocarp and juice sacks of various citrus fruits is collected. The collected exocarp and mesocarp are coarsely pulverized with, e.g. a commercial available mixer. An aqueous solution prepared by adding a prescribed amount of an organic acid salt to the pulverized pericarp or juice sacks covered with the residual endocarp and a mixture obtained by adding the organic acid salt to the juice sacks or a fruit juice are then stirred for a further prescribed time and allowed to stand at normal temperature or in a refrigerator. Thereby, the mixture is coagulated to produce the colored translucent agar-like substance containing the citrus fruit pericarp.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The invention provides a novel composite iodine disinfectant as well as a preparation method and an application thereof. The novel composite iodine disinfectant is prepared from raw materials, including quaternary ammonium salt, iodine, potassium iodate, inorganic acid and water, in percentage by weight. The preparation method comprises steps as follows: firstly, the quaternary ammonium salt, the inorganic acid and the water are mixed, heated and heat-insulated, then the iodine and the potassium iodate are added, and a continuous heat-insulation mixing reaction is conducted until the iodine is completely dissolved. The composite iodine disinfectant has characteristics of the high sterilization speed and the high efficiency of iodine disinfectants as well as the characteristic of long sterilization and bacteriostatic duration of quaternary ammonium salt disinfectants, so that the usage frequency can be reduced. The preparation method is simple, the technological process is simple and easy to control, the production cycle is short, the production cost is low, and the method is suitable for industrial production. The composite iodine disinfectant can be used as a sterilization product applied to preparation of main components and is good in stability, non-toxic and non-irritating; the composite iodine disinfectant can also be applied to sterilization of animal husbandry and aquaculture and is good in sterilization and bacteriostatic effect.
Gestational diabetes is the development of diabetes during pregnancy. According to the National Institutes of Health, gestational diabetes occurs in about 5 percent of all pregnancies in the United States, resulting in about 200,000 cases a year. Treatment involves dietary measures, exercise and, in some cases, insulin injections. All pregnant women should be taking a prescribed pre-natal vitamin, and should also supplement with fish oil or another source of omega-3 fatty acids to help support the nervous system of their developing child.

Left untreated, gestational diabetes and preeclampsia can lead to serious -- or even fatal -- complications for both mother and child. In diabetic pregnancies there is an increased risk of birth defects. Some evidence suggesting omega-3 fatty acids might help protect women from two serious pregnancy complications -- gestational diabetes and preeclampsia. Omega-3 fatty acids, in particular Docosahexaenoic acid (DHA), help a pregnant woman give her developing baby every advantage in life starting in-utero. In general the omega-3 fatty acids found in fish help the cardiovascular system, the brain (including moods), and even the brain and eyes of a developing baby. The risk of pre-term delivery and low birth weight is three and a half times higher when mothers are deficient in DHA. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. In this study the investigators aimed to examine the effect of fish oil supplementation in women with gestational diabetes mellitus on newborn outcomes and insulin like growth factor 1 DNA methylation.
The invention discloses a functionalized chitosan porous microsphere for repairing cartilage injury and a preparation method thereof. Adding a chitosan acetic acid solution into an organic solvent, stirring to form a W/O emulsion, dropwise adding the W/O emulsion into a precooled glass plate containing the same organic solvent, adding absolute ethyl alcohol for dehydration after emulsion droplets are solidified into balls, and finally adding a sodium hydroxide solution to neutralize the acetic acid remained in the microspheres. Adding glutaraldehyde into the microspheres washed to be neutral for further chemical crosslinking, removing free glutaraldehyde by using glycine, cleaning, and freeze-drying to obtain the chitosan porous microspheres. The micromolecular drug KGN is connected with the chitosan porous microsphere in a chemical bonding mode, so that the differentiation bioactivity of the bone marrow mesenchymal stem cells is endowed. The chitosan porous microsphere prepared by the invention has a three-dimensional network porous structure with a bionic structure, and provides space and conditions for the formation and growth of new cartilage cells. The preparation method is simple, has a controllable structure and good sphericity, and has a wide application prospect in the field of cartilage tissue regeneration.
BACKGROUND: Sepsis not only causes inflammation, but also damages the heart and increases the risk of death. The glycolytic pathway plays a crucial role in the pathogenesis of sepsis-induced cardiac injury. This study aims to investigate the value of bisphosphoglycerate mutase (BPGM), an intermediate in the glycolytic pathway, in evaluating cardiac injury in septic patients and predicting poor prognosis in sepsis.
METHODS: This prospective study included 85 patients with sepsis. Serum BPGM was measured at the time of enrollment, and the patients were divided into a BPGM-positive group (n = 35) and a BPGM-negative group (n = 50) according to their serum BPGM levels. Baseline clinical and echocardiographic parameters, and clinical outcomes were analyzed and compared between the two groups. Kaplan-Meier analysis was used to compare the 28-day survival rate between BPGM-negative and BPGM-positive patients. Multivariate logistic regression analysis was conducted to explore the independent risk factors for 28-day mortality in septic patients. The predictive value of serum BPGM for sepsis-induced myocardial injury and poor prognosis in sepsis was evaluated using receiver operating characteristic (ROC)curve analysis.
RESULT: The serum level of BPGM was significantly higher in patients who died within 28 days compared to survivors (p < 0.001). Kaplan-Meier analysis showed that serum BPGM-positive sepsis patients had a significantly shorter 28-day survival time (p < 0.001). Multivariate logistic regression analysis showed that serum BPGM (OR = 9.853, 95%CI 1.844-52.655, p = 0.007) and left ventricular ejection fraction-simpson(LVEF-S) (OR = 0.032, 95% CI 0.002-0.43, p = 0.009) were independent risk factors for 28-day mortality in sepsis patients. Furthermore, BPGM levels was negatively correlated with LVEF-S (p = 0.005) and positively correlated with the myocardial performance (Tei) index (p < 0.001) in sepsis patients. ROC curve analysis showed that serum BPGM was a good predictor of septic myocardial injury and 28-day mortality in sepsis patients.
CONCLUSION: The level of BPGM in the serum of sepsis patients can serve as a monitoring indicator for myocardial injury, with its high level indicating the occurrence of secondary myocardial injury events and adverse outcomes in sepsis patients.
Subjects received 0.05% atropine eye drops (0.1% sodium hyaluronate as a solution) both eyes once every night. Eye drops are prepackaged with identical eye drops bottle, pasted with number and shelf life, and stored in 4℃.
PROBLEM TO BE SOLVED: To obtain a bathing material composition excellent in refreshed feeling of the skin and warm feeling of the body by blending a plant of the family Menispermaceae. SOLUTION: This bathing material composition contains a plant of the family Menishpermaceae and preferably contains inorganic salts, organic acids, carbonates and oil-based components. The composition is used for bathing by applying or sticking it to the body. As the plant of the family Menispermaceae, Sinomenium actum Rehder et Wilson, Ccculus trilobus DC, Cocculus laurifolius DC., etc., are preferable. Especially Sinomeni Caulis et Rgizoma, which are roots and stems of Sinomenium actum Rehder et Wilson, are preferable. The plant is used in an untreated state, a squeezed juice, a solvent extract, etc. The blending amount of the plant is preferably >=0.005wt.%, especially 0.01-20wt.% of the dried solvent extract based on the composition.
UNLABELLED: This study was designed to evaluate serum LC3-II, BCL-2, IL-1β, TGF-β1, and podocin levels in. type 2 diabetes (T2DM) patients with renal dysfunction.
MATERIALS: 176 Turkish subjects were enrolled, of whom 26 were healthy, and 150 had T2DM.
PATIENTS: were classified according to albumin urea ratio: 88 patients had macroalbuminuria, 20. patients had microalbuminuria, and 42 had normoalbuminuria. T2DM patients were also. classified into three groups according to proteinuria and eGFR stages.
RESULTS: Increased serum LC3-II levels in patients with T2DM with increased urinary albumin. extraction and impaired renal functions. There was a strong relationship between serum. LC3-II levels and serum BCL-2, IL-1β, TGF-β1, and Podocin levels. The efficiency of LC3- II as a diagnostic biomarker in the differential diagnosis of DM patients with. macroproteinuria from DM patients with normoproteinuria was 75.4%.
CONCLUSIONS: It was thought that increased serum LC3-II levels in T2DM patients with impaired renal. functions may cause renal podocyte damage. In these patients, serum LC3-II levels can be. evaluated as a new biomarker to follow the development of renal damage.
A new, structured education for heart healthy food choices and low glycemic index in type 1 diabetes. The education is called "My Wellness-LADDER" (Lifelong Adult Diet \& Diabetes Education Resource) and it is specifically designed to provide high long-term adherence through improved empowerment and transformative life style change.
A perineal infiltration of a 5-ml of the drug (100 mg of lignocaine) in the margins of the episiotomy. Careful aspiration before and during injection of the product should be performed to prevent intravascular injection. The entire contents will then be injected slowly at several points of infiltration. All planes will be infiltrated (vagina, muscle, and skin) before episiotomy repair.
Promotant comprises microgranules having a core consisting of one or more enzymes selected from: (i) protein digesting enzymes, (ii) carbohydrate digesting enzymes, (iii) fat digesting enzymes and (iv) fibre digesting enzymes, the core being encapsulated within a water soluble film and coated with an enteric coating comprising an alkali soluble, acid insoluble polymer or a high mol. wt. polymer whose structure is substd. with or contains windows of fatty acid or other material capable of being solubilised by intestinal juices. Pref. the core comprises enzyme(s) immobilised within a gel-like matrix of e.g. K-carrageenan, gelatin, alginates, cellulose or its derivs. or gel forming synthetic polymers. Pref. the water soluble film is gelatin and the alkali soluble acid insoluble polymer is cellulose acetate phthalate. The high mol. wt. polymer is pref. butyl methacrylate.
Impaired Liver Function 

Do not use ELINESTTM in women with liver disease, such as acute viral hepatitis or severe (decompensated) cirrhosis of the liver [see Contraindications]. Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal and COC causation has been excluded. Discontinue ELINESTTM if jaundice develops.

Liver Tumors 

ELINESTTM is contraindicated in women with benign and malignant liver tumors [see Contraindications]. Hepatic adenomas are associated with COC use. An estimate of the attributable risk is 3.3 cases/100,000 users. Rupture of hepatic adenomas may cause death through intra-abdominal hemorrhage.

Studies have shown an increased risk of developing hepatocellular carcinoma in long-term (>8 years) COC users. However the risk of liver cancers in COC users approaches less than one case per million users.

Risk Of Liver Enzyme Elevations With Concomitant Hepatitis C Treatment 

During clinical trials with the Hepatitis C combination drug regimen that contains ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN), including some cases greater than 20 times the ULN, were significantly more frequent in women using ethinyl estradiol-containing medications such as COCs. Discontinue ELINESTTM prior to starting therapy with the combination drug regimen ombitasvir/paritaprevir/ritonavir, with or without dasabuvir [see Contraindications]. ELINESTTM can be restarted approximately 2 weeks following completion of treatment with the combination drug regimen.
PURPOSE: Caregivers of deaf/hard of hearing infants are faced with challenging decisions regarding their child's communication method. The purpose of the current research note is to characterize the advice that caregivers receive and value as well as the factors that influence caregivers' decision making.
METHOD: The current study enrolled 105 caregiver-child dyads, including children between 12 and 18 months of age with bilateral, congenital hearing loss. All children were exposed to spoken language, and 63.81% of children were also exposed to sign language. Caregivers completed the "Making Decisions About Sign, Speech, and Multilingualism Survey" (Crowe et al., 2014).
RESULTS: Caregivers most frequently received advice to use both speech and sign and highly valued advice from speech-language pathologists. When considering the use of speech, the factors that caregivers most frequently rated as very important were "My child's future academic success" (96.19%), "My child's future literary success" (95.24%), and "My child's future access to higher education" (95.19%). When considering the use of sign, the factors that caregivers most frequently rated as very important were "My child's ability to form friendships and future relationships" (82.52%), "My child's future literary success" (81.37%), and "My child's future academic success" (81.37%).
CONCLUSIONS: Results of the current study suggest that throughout the decision-making process, caregivers' highest priority is understanding how their decisions will influence their child's future access to opportunities and relationships. Providers may consider discussing these factors early in the decision-making process to support caregivers' ability to make an informed choice regarding their child's communication method.
A fluid base composition for use as a vehicle for toilet and cosmetic preparations contains in aqueous medium either ethyl alcohol or a mixture thereof with isopropyl alcohol; glycerine, and/or a monoglyceride; urea and/or a urethane; bile salts; and a thickening agent.  The thickening agent is preferably an aqueous quince seed extract, but solutions of methyl cellulose may also be used.  The bile salts may be in the form of commercial sodium taurocholate, or other preparations from ox gall.  Optional additions include fused bentonite-sulphur, salicylic acid synthetic oil of Rose Neil and colouring agents.  The composition may be in the form of a liquid, a cream or a paste and is compatible with soap solutions and creams to form shaving creams and shampoos.  The Specification as open to inspection under Sect. 91 refers to the preparation having medicinal properties.  This subject-matter does not appear in the Specification as accepted.
OBJECTIVE: Mouse models of hindlimb ischemia (HLI) are used to study peripheral arterial disease and evaluate novel therapies. Contrast-enhanced ultrasound (CEUS) is a noninvasive perfusion measurement technique that is increasingly being employed in these models. The objective of this study was to evaluate two models of severe HLI by CEUS to characterize perfusion recovery and muscle perfusion patterns.
METHODS: Mice undergoing double femoral artery ligation were measured by CEUS and laser Doppler perfusion imaging (LDPI) at baseline and 1-150 d postsurgery. A second group undergoing femoral artery ligation and excision was measured 1-28 d postsurgery.
RESULTS: By LDPI, both surgeries showed robust perfusion recovery by 14 d postsurgery. However, by CEUS only a ∼40% perfusion recovery plateau was reached in either group. These results are consistent with our previous work, employing a less severe single femoral artery ligation, that showed perfusion in the ischemic limb does not return to normal by 150 d postsurgery. Cluster analysis of muscle perfusion patterns indicated 3-5 different patterns at day 1 postsurgery. The double ligation model yielded significantly less variable perfusion patterns, suggesting that it can provide more reproducible results.
CONCLUSION: Contrary to LDPI, perfusion as measured by CEUS never fully recovers after hindlimb surgery, even when followed 28-150 d postsurgery. Individual mice can manifest different patterns of muscle perfusion to the same surgery, but these patterns are conserved within and between different surgical techniques. These results may have significant implications for the evaluation of novel therapeutics to treat PAD in mice.