anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicine formula for treating rheumatism and a preparation method thereof. The formula is formed by elaborately selecting natural Chinese herbal medicine raw materials and compounding the raw materials repeatedly through clinical tests. The dialectic guiding principles of the exterior and the interior, the cold and heat, deficiency and excess and the eight principal syndromes related to yin and yang are put forward according to traditional Chinese medicine and used for conducting comprehensive analysis on disease. According to the traditional Chinese medicine formula for treating exterior and interior rheumatism and the preparation method thereof, the interior qi and blood and viscera physiological functions of the human body are adjusted on the whole, and corresponding drug therapy is conducted on correlated symptoms. Homalomena occulta, lycopodium clavatum, rhizoma typhonii, elecampane, sargent gloryvine, felwort, peach kernels, codonopsis pilosula, Chinese holly leaves, licorice roots and safflower carthamus work as a group to eliminate anemofrigid-damp arthralgia inside the human body, damp toxin is removed, and muscles and bones are strengthened. Epimedium herbs, mulberry twigs, radix sileris, fructus psoraleae, herba siegesbeckiae, three-nerved spicebush roots, cortex albiziae, rhizoma smilacis glabrae,cinnamon, akebiaquinata and licorice roots work as a group to eliminate exterior rheumatism and rheumatic pyretic arthralgia and wind-cold syndromes. The two groups of formulas cooperate with each other, various rheumatic type diseases are treated in a dialectical and comprehensive mode, the formula works on the nidus directly, and a good cure effect is achieved on a rheumatism patient.
INTRODUCTION: The eyelids are a common site for skin tumours and account for 5-10% of all skin tumours. Treatment is mainly surgical and aims to preserve the anatomical structure of the eyelid, its function and not least its aesthetic appearance.
AIM: Presentation of recurrence and complication rates of tumour-related eyelid surgery in a cohort of 450 tumours.
RESULTS: Analysis of a cohort of 450 tumours operated on revealed 13 (2.8%) operations with recurrences and 32 (7%) with complications. The statistical significance of recurrences was observed for the involved and uninvolved ciliary margin. At the temporal canthus, 23.1% of recurrences occurred compared to 7.7% at the medial canthus. SGC has the highest recurrence rate. Complications include the following: ectropion, dehiscence, gross cicatrix with normal function, retraction, post-radiation damage, sub-graft haemorrhage and graft rejection.
CONCLUSIONS: The recurrence rate of eyelid tumours is lower than that of complications. The choice of surgical technique determines the frequency of complications and histological control of the excised tissue, as well as the frequency of recurrences.
The plants of the Opuntia genus mainly grow in arid and semi-arid climates. Although the highest variety of wild species is found in Mexico, Opuntia spp. is widely distributed throughout the world. Extracts of these cacti have been described as important sources of bioactive substances that can have beneficial properties for the prevention and treatment of certain metabolic disorders. The objective of this review is to summarise the presently available knowledge regarding Opuntia ficus-indica (nopal or prickly pear), and some other species (O. streptacantha and O. robusta) on obesity and several metabolic complications. Current data show that Opuntia ficus-indica products used in preclinical studies have a significant capacity to prevent, at least partially, obesity and certain derived co-morbidities. On this subject, the potential beneficial effects of Opuntia are related to a reduction in oxidative stress and inflammation markers. Nevertheless, clinical studies have evidenced that the effects are highly contingent upon the experimental design. Moreover, the bioactive compound composition of nopal extracts has not been reported. As a result, there is a lack of information to elucidate the mechanisms of action responsible for the observed effects. Accordingly, further studies are needed to demonstrate whether Opuntia products can represent an effective tool to prevent and/or manage body weight and some metabolic disorders.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to the field of pharmaceutical industry and medicine and is intended for treatment of wounds and burns. Hemostatic and wound healing agent is described, having the following composition, wt %: polyvinylpyrrolidone - 2.0-10.0, agar - 1.0-3.0, polyethylene oxide - 1.0-3.0, aminocapronic acid - 0.01-5.0, water - balance. Agent is produced by linkage of medical-purpose polymers under action of ionising radiation. ^ EFFECT: agent has elasticity, tensile strength, sorbtion effect relative to wound exudate, transparency, which makes it possible to follow course of wound process, painless removal from wound surface, creates optimal microclimate in wound (humidity, temperature), provides for hemostatic and wound healing effects. ^ 3 ex
Real-time diagnosis of intracerebral hemorrhage after thrombectomy is crucial for follow-up treatment. However, this is difficult to achieve with standard single-energy CT (SECT) due to similar CT values of blood and contrast agents under a single energy spectrum. In contrast, dual-energy CT (DECT) scanners employ two different energy spectra, which allows for real-time differentiation between hemorrhage and contrast extravasation based on energy-related attenuation characteristics. Unfortunately, DECT scanners are not as widely used as SECT scanners due to their high costs. To address this dilemma, in this paper, we generate pseudo DECT images from a SECT image for real-time diagnosis of hemorrhage. More specifically, we propose a SECT-to-DECT Transformer-based Generative Adversarial Network (SDTGAN), which is a 3D transformer-based multi-task learning framework equipped with a shared attention mechanism. In this way, SDTGAN can be guided to focus more on high-density areas (crucial for hemorrhage diagnosis) during the generation. Meanwhile, the introduced multi-task learning strategy and the shared attention mechanism also enable SDTGAN to model dependencies between interconnected generation tasks, improving generation performance while significantly reducing model parameters and computational complexity. In the experiments, we approximate real SECT images using mixed 120kV images from DECT data to address the issue of not being able to obtain the true paired DECT and SECT data. Extensive experiments demonstrate that SDTGAN can generate DECT images better than state-of-the-art methods. The code of our implementation is available at https://github.com/jiang-cw/SDTGAN.
1,153,061. Hair lacquers &c. L'OREAL. 13 May, 1966 [13 May, 1965; 20 April, 1966], No. 21393/66. Heading ASB. [Also in Divisions C3 and C4] Hair lacquers and wave-setting lotions comprise an alcoholic or aqueous alcoholic solution of at least one coloured addition copolymer of (a) at least one monomer free from epoxy groups and (b) at least monomer having an epoxy group, said copolymer having bonded thereto at least one dyestuff containing an extra nuclear primary or secondary amine group, and said amine group being condensed with said epoxy group. Monomer component (a) may be selected from vinyl acetate, N- vinyl-pyrrolidone, alkyl acrylates and methacrylates, and acrylamide, methacrylamide and their substituted derivatives. Component (b) is preferably selected from glycidyl acrylate, glycidyl metnacrylate and allyl glycidyl ether. The compositions may additionally include a colourless polymer such as polyvinyl pyrrolidone or a vinyl pyrrolidone/vinyl acetate copolymer. Other optional components include plasticisers, perfumes, surface-active or wetting agents, penetrating agents, and aerosol propellants.
PURPOSE:To obtain a new phospholipidic ascorbic acid derivative, excellent in beautifying and whitening action on the skin and preventive action on skin roughening and useful as a skin medicine for external use and its salt. CONSTITUTION:A compound, e.g. 1-palmitoyl-sn-glycero-3-phosphoascorbic acid expressed by formula I (R<1> is fatty acid residue). The aforementioned compound is obtained by reacting a 1,2-diacyl-sn-glycero-3-phosphoascorbic acid expressed by formula II (R<2> is fatty acid residue; R<1> and R<2> may be the same or different) with phospholipase A2 (E.C. 3.1.1.4) in an organic solvent (e.g. diethyl ether) at 27-33 deg.C for 2-4hr. The resultant compound expressed by formula I is included as an active ingredient in an amount of 0.1-10wt.% based on the total amount to prepare the objective skin medicine for external use. Since the obtained skin medicine for the external use has also emulsifiability, skin penetrating and oxidation resistance, it can also be applied to the fields of foods and medicines.
Nipple discharge is the third most common breast related symptom for which women seek medical care, accounting for 37% of all breast complaints. Pathologic nipple discharge (PND) is defined as spontaneous or easily expressible single duct nipple discharge, which contributes to 5% of referrals to breast surgeons. Patients with PND represent a diagnostic and therapeutic challenge for the surgical clinician. The most frequent causes of PND in these cases are intraductal papilloma (IP) in 36% to 66%, ductal carcinoma in situ (DCIS) in 3% to 20% and other benign causes in up to 23%. The evaluation of women with PND usually involves radiological(mammography, ultrasound, ducto (galacto)graphy and cytological (nipple smear, ductal lavage) examinations; however, each of these procedures has found to have low sensitivity and specificity. A ductoscope is an instrument which allows visualization of abnormalities and polypoid lesions within the ductal system with access via the nipple orifice to aid in evaluation of PND. Moreover, it is currently being used to improve localization of lesions in patients with PND. Ductoscopically guided excision is an improvement over standard surgical approaches with terminal duct excision which removes a large volume of tissue with potential cosmetic deformity and for young women may make breast feeding not possible. Ductoscopy also allows retrieval of intraductal cells for diagnostic purposes using brush cytology.
Only the test side that will be intervened with i-PRF will be obtained from the upper liquid layer and will be placed in dental injectors using a 27 mm gauged needle. During the first application the amount of i-PRF will be standardized as 4 mL and injected through intra-ligamental into the disto-buccal and disto-palatal side of the canine tooth (2 mL for each side) and at the time of second intervention i.e 8th week form the baseline intramucosal injection will be administered equidistant from the maxillary canine and second premolar, 2ml on buccal side and 2ml on palatal side) after anesthetizing the region with local anesthesia (2% Lignocaine).
PURPOSE: Quantitative MRI techniques such as T2 mapping are useful in comprehensive evaluation of various pathologies of the knee joint yet require separate scans to conventional morphological measurements and long acquisition times. The recently introduced 3D MIXTURE (Multi-Interleaved X-prepared Turbo-Spin Echo with Intuitive Relaxometry) technique can obtain simultaneous morphologic and quantitative information of the knee joint. To compare MIXTURE with conventional methods and to identify differences in morphological and quantitative information.
METHODS: Phantom studies were conducted, and in vivo human scans were performed (20 patients) presented with knee arthralgia. MIXTURE is based on 3D TSE without and with T2 preparation modules in an interleaved manner for both morphology with PDW and fat suppressed T2W imaging as well as quantitative T2 mapping within one single scan. Image quality and lesion depiction were visually assessed and compared between MIXTURE and conventional 2D TSE by two experienced radiologists. Contrast-to-noise ratio was used to assess the adjacent tissue contrast in a quantitative way for both obtained PDW and fat suppressed T2W images. Quantitative T2 values were measured in phantom and from in vivo knee cartilage.
RESULTS: The overall diagnostic confidence and contrast-to-noise ratio were deemed comparable between MIXTURE and 2D TSE. While the chosen T2 preparation modules for MIXTURE rendered consistent T2 values comparing to the current standard, measured cartilage T2 values ranged from 26.1 to 50.7 ms, with significant difference between the lesion and normal areas (p < 0.05).
CONCLUSIONS: MIXTURE can help to provide high-resolution information for both anatomical and pathological assessment.
The course of Common Elements Treatment Approach (CETA - the intervention under study) is built to be flexible depending on need. Mild symptoms could result in fewer sessions (e.g., 5), while greater severity may require 8-12 sessions.
NEW MATERIAL:A compound expressed by formula I (m and n are 2-5, provided that when either of m and n is 2, the other is 3-5) or salts thereof. EXAMPLE:Calcium 2-[4-(2,4-dihydroxy-3,3-dimethylbutylamino) butyrylamino]ethylthiosulfonate. USE:A cosmetic material, excellent both in moisture absorbing and humectant action and in tyrosinase inhibitory action and especially useful as cosmetic materials for preventing aging. PREPARATION:A 2,4-dihydroxy-3,3-dimethylbutylaminoalkylcarboxylic acid expressed by formula II or salt thereof is reacted with an aminoalkylthiosulfonic acid expressed by formula III in the presence or absence of a condensing agent (e.g. dicyclohexylcarbodiimide) in or without a solvent (e.g. water or pyridine) at ambient temperature or while being heated to afford the compound expressed by formula I.
The present document discloses the formation of imine adducts, preferably between a primary amine of a biologically active polypeptide and a reactive aldehyde group of a physiologically acceptable carrier. The imine adduct of human growth hormone and dextran is specifically described. These adducts serve to release the biologically active polypeptide via the reversible reaction in the formation of the imine adduct bond. These adducts have a surprising degree of stability that permits the use of the complex as a sustained release preparation. A key advantage of this technology is that after hydrolysis the complex releases the unmodified pharmaceutical. Thus, these adducts can be used as pharmaceutical compositions useful for the sustained release of the biologically active polypeptide over a predetermined, desired period of time.
The aim of this study was to explore the efficacy and safety of Trastuzumab-Deruxtecan (T-DXd) in metastatic breast cancer (mBC). This retrospective observational study was conducted between January 2021 and 2023. Patients' clinical and pathological characteristics and previous medicinal treatments were reviewed. The efficacy of T-DXd and its influencing factors, as well as the adverse reactions of T-DXd were also observed. The median age of the patients was 43 years, and the median number of treatment lines was 4. In the overall population, the objective response rate (ORR) was 72.7%, the disease control rate (DCR) was 90.9%, and the median progression-free survival (mPFS) was six months. Among them, two patients temporarily discontinued treatment after two cycles of T-DXd due to financial reasons, but their disease remained stable for 5 and 8 months, respectively. Efficacy was better in patients with HER-2 amplification, who had not previously used antibody drug conjugates (ADC) drugs, were sensitive to anti-HER-2 treatment, and had ≤3 lines of therapy. Common adverse reactions during T-DXd treatment included gastrointestinal reactions such as nausea, vomiting, diarrhoea, and constipation, as well as haematological toxicities, decreased appetite, hair loss, and fatigue. Some patients experienced gastritis, abnormal liver function, and weight gain, but none of the patients developed interstitial pneumonia. T-DXd can achieve significant and durable survival benefits with controllable safety in patients with HER2-positive or HER2 low-expressing mBC. Key Words: Metastatic breast cancer, Trastuzumab-Deruxtecan, Efficacy, Safety.
Chronic physical illnesses (CPI) are highly prevalent among people with serious mental illnesses (PWSMI) yet people in this population experience significant challenges accessing healthcare. This study utilised a constructivist grounded theory approach to collect and analyse data related to the enablers and barriers to public healthcare access for PWSMI & CPI. Data were collected through semi-structured interviews conducted with fifty-seven participants comprising PWSMI &CPI and their caregivers, health policymakers, primary care physicians, psychiatrists, and mental health nurses. Enablers and barriers to healthcare access were represented using a socio-ecological model consisting of five levels: wider society, health system, clinician, family and community, and individual. Jamaica's free public healthcare system was the most pronounced enabler of healthcare access, while poverty, stigma, and discrimination were the most pronounced barriers. Factors such as social support, time, clinician beliefs, attitudes and training, and individual characteristics were identified as consisting of dimensions that were both enablers and barriers to healthcare access. These findings indicated that factors that influenced healthcare access for PWSMI & CPI were aligned with the social determinants of health. Improved healthcare access for PWSMI & CPI necessitates strategies that incorporate a multi-sectoral approach to address social and environmental factors influencing healthcare access across all levels of the socio-ecological model.
PURPOSE: An anti-atopic composition containing cell permeable peptide-conjugated nanoliposome is provided to maximize atopic dermatitis treatment effect. CONSTITUTION: A nanoliposome has an anti-atopy active material and has a cell permeable peptide which is coupled on the surface. The anti-atopy active material is taxifolin 3-O-beta-D-glucopyranoside. A lipid forming the nanoliposome is phospholipid. The phospholipid is phosphocholine of 3-24 carbon atoms. The nanoliposome contains polysorbate 80, span 80, sodium cholate, dipotassium glycyrrhizinate, lysophosphatidylcholine, or ethanol.
Imaging, object tracking, integration apparatus  100  has tracking system  1,  imaging system  3,  communication system  5  and integration system  7.  Tracking system  1  locates objects in 3-dimensions and determines respective poses. Imaging system  3  acquires object images. Integration system  7  correlates 3-dimensional poses. User communication system  5  provides information, such as images, sounds, or control signals to the user or other automated systems. Image acquisition techniques include X-ray imaging and ultrasound imaging. Images can be acquired from digital files. Imaging system  3  creates a calibrated, geometrically corrected two-dimensional image  110, 210 . Correlation system  7  can receive instructions from a practitioner to create, destroy, and edit the properties of a guard. Communications system  5  displays images and calculations to a practitioner, such as a surgeon. Methods can determine geometrical relations between guards and/or present to a practitioner projections of forms of guards.
SCANDONEST stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthesia.

SCANDONEST is rapidly metabolized, with only a small percentage of the anesthetic (5 to 10 percent) being excreted unchanged in the urine. SCANDONEST because of its amide structure, is not detoxified by the circulating plasma esterases. The liver is the principal site of metabolism, with over 50 percent of the administered dose being excreted into the bile as metabolites. Most of the metabolized Mepivacaine is probably resorbed in the intestine and then excreted into the urine since only a small percentage is found in the feces. The principal route of excretion is via the kidney. Most of the anesthetic and its metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation, which are detoxification reactions, play important roles in the metabolism of the anesthetic. Three metabolites of Mepivacaine have been identified from adult humans: two phenols, which are excreted almost exclusively as their glucuronide conjugates, and the N-demethylated compound (2', 6' - pipecoloxylidide).

The onset of action is rapid (30 to 120 seconds in the upper jaw; 1 to 4 minutes in the lower jaw) and SCANDONEST 3% (30 mg/mL) Plain will ordinarily provide operating anesthesia of 20 minutes in the upper jaw and 40 minutes in the lower jaw.

SCANDONEST 2% (20 mg/mL) L with Levonordefrin 1:20,000 provides anesthesia of longer duration for more prolonged procedures, 1 hour to 2.5 hours in the upper jaw and 2.5 hours to 5.5 hours in the lower jaw.

SCANDONEST does not ordinarily produce irritation or tissue damage.

Levonordefrin is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions. It has pharmacologic activity similar to that of Epinephrine but it is more stable than Epinephrine. In equal concentrations, Levonordefrin is less potent than Epinephrine in raising blood pressure, and as a vasoconstrictor.
This clinical study examined the impact of eight predictors (age at stroke, stroke type, lesion size, lesion location, time since stroke, neurologic severity, seizures post-stroke, and socioeconomic status) on neurocognitive functioning following pediatric stroke. Youth with a history of pediatric ischemic or hemorrhagic stroke (n = 92, ages six to 25) underwent neuropsychological testing and caregivers completed parent-report questionnaires. Hospital records were accessed for medical history. Spline regressions, likelihood ratios, one-way analysis of variance, Welch's t-tests, and simple linear regressions examined associations between predictors and neuropsychological outcome measures. Large lesions and lower socioeconomic status were associated with worse neurocognitive outcomes across most neurocognitive domains. Ischemic stroke was associated with worse outcome in attention and executive functioning compared to hemorrhagic stroke. Participants with seizures had more severe executive functioning impairments than participants without seizures. Youth with cortical-subcortical lesions scored lower on a few measures than youth with cortical or subcortical lesions. Neurologic severity predicted scores on few measures. No differences were found based on time since stroke, lesion laterality, or supra- versus infratentorial lesion. In conclusion, lesion size and socioeconomic status predict neurocognitive outcome following pediatric stroke. An improved understanding of predictors is valuable to clinicians who have responsibilities related to neuropsychological assessment and treatments for this population. Findings should inform clinical practice through enhanced appraisals of prognosis and the use of a biopsychosocial approach when conceptualizing neurocognitive outcome and setting up support services aimed at fostering optimal development for youth with stroke.