anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Renal biopsy remains the gold standard for diagnosing membranous nephropathy (MN). Recent studies have suggested that renal biopsy can be replaced with the serum phospholipase A2 receptor (PLA2R) antibody test for MN diagnosis in patients with nephrotic syndrome. However, this test has not been validated in the Chinese population. In this study, we investigated whether renal biopsy provides additional diagnostic information on patients with proteinuria who are seropositive for PLA2R antibodies (SAb +). We retrospectively reviewed the clinicopathological characteristics of SAb + adult patients (aged ≥ 18 years) with proteinuria (≥ 0.5 g/24 h) assessed at the Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, from June 2021 to March 2022. Among a total of 801 SAb + patients who received renal biopsy, those with incomplete pathological data, diabetes or any potential cause of secondary MN were excluded. Among the 491 remaining patients, 474 had primary MN (PMN), 16 had atypical MN (AMN, 9 patients with "full house" and 2 patients with HBsAg + /HBcAg + immunofluorescence results), and 1 had focal segmental glomerulosclerosis. In patients with an eGFR of ≥ 60 mL/min/1.73 m2 (n = 451), 436 had PMN, and 71 (16.3%) exhibited additional biopsy findings, with obesity-related glomerulopathy being the most common. In patients with an impaired eGFR (n = 40), 38 had PMN, and 31 (81.6%) showed additional findings, with acute tubular injury being the most common. In conclusion, anti-PLA2R antibody positivity is highly predictive of PMN in Chinese adults but often coexists with other pathological diagnoses. The advantages of renal biopsy for detecting other pathologies should be weighed against the potential risks of the biopsy procedure.
INTRODUCTION: Previous studies have demonstrated the benefits of tranexamic acid (TXA) administration in combination with packed red blood cell (PRBC) transfusion in trauma patients without increasing the risk of venous thromboembolism (VTE). However, the effect of TXA in combination with whole blood (WB) has not been studied. Injury, abbreviated injury severity scores (ISS and AIS) and the need for blood transfusions are historically associated with VTE. The objective of this study was to determine the relationship between VTE and the combination of TXA administration and transfusion of PRBCs vs. WB.
METHODS: Our institutional trauma registry was queried for trauma patients between 2015 and 2022 who received either WB ​+ ​TXA or PRBC ​+ ​TXA either prehospital or within 4 ​h of arrival. Multivariate analysis was utilized to determine independent risk factors for VTE, which were defined as either a deep vein thrombosis (DVT) or a pulmonary embolism (PE). Model covariates included age, mechanism of injury (MOI), ISS, lower extremity AIS, comorbid conditions, and shock index (SI). Additional outcomes analyzed were hospital length of stay (LOS), ICU LOS, and ventilator days.
RESULTS: Three hundred and five patients had complete data and were included in the analysis. Of those, 251 received WB ​+ ​TXA and 54 received PRBC ​+ ​TXA. A total of 34 patients were found to have VTE event (11.1 ​%); 28 (11.2 ​%) and 6 (11.1 ​%) from the WB ​+ ​TXA and PRBC ​+ ​TXA groups, respectively. An elevated pre-hospital SI was independently associated with increased VTE rate (OR 1.85, 95 ​% CI 1.07-3.20). WB transfusion, TXA administration, ISS, and MOI did not influence the rate of VTE.
CONCLUSION: These data demonstrate that the combination of WB ​+ ​TXA administered to trauma patients has no higher risk of VTE than patients who receive PRBC ​+ ​TXA, a comparison that has not been studied clinically to date. Despite the pro thrombotic state enhanced by TXA and the decreased dilutional coagulopathy seen in WB resuscitation, there was no increased risk of VTE compared to TXA ​+ ​PRBC. There is no evidence that TXA combined with whole blood transfusion is associated with an increased risk of VTE. However, higher pre-hospital SI was associated with an elevated rate of VTE. These clinical features provide insight into patients who may be at an increased risk of developing VTE and may benefit from targeted prevention strategies.
Reduction in beds coupled with the increased need for health care services has led to a supply and demand struggle or capacity management challenge for health care facilities. This is now recognized as a major public health issue. The impact is readily seen as overcrowding in emergency departments. At present 76% of hospitals' emergency departments (ETDs) are at or over capacity with 33% reporting ambulance diversions, the most common sign of overcapacity within a health care facility. Compounding the physical capacity problem is the "human capacity strain" as admitted patients remain in the ETD for prolonged periods waiting for beds. Delayed admission to patient care units significantly strains the financial resources, impedes "patient flow" ultimately impacting the quality of care, patient satisfaction and the "bottom line." Discharge before 11 am optimizes the availability of hospital beds to meet admission demands thereby avoiding a surge over capacity or "patient back log", ambulance diversions in ETD; the post anesthesia recovery unit, admissions office and critical care units. Conversely competing needs for the attending physician's physical presence off of the hospital premises; off of the unit (private practice and meetings) often delays patient discharge from before 11 am to the afternoon and evening.
PURPOSE: The study's aims were (a) to evaluate hearing status and (b) word recognition ability of Hmong speakers using four validated monosyllabic word recognition tests in the White Hmong dialect and (c) to assess the relationship between the participant's language and the average word recognition percent correct scores, adjusting for age, gender, and degree of hearing loss.
METHOD: Participants listened to two randomly assigned validated Hmong word lists (male/female talker) for each ear. Pure-tone air- and bone-conduction thresholds as well as word recognition ability were measured. Descriptive statistics were calculated to analyze the percent correct of word lists and classify hearing status. A nonparametric regression analysis was used to assess the relationship between the participant's language and the average word recognition percent correct scores, adjusting for age, gender, and degree of hearing loss.
RESULTS: Forty-eight Hmong (25 females, 23 males; Mage = 44.4) participated in this study. Thirty-three participants had hearing loss in at least one ear, and 15 had hearing within normal limits bilaterally. Participants with normal, mild, or steeply sloping hearing loss reached an average word recognition score of > 94% on Hmong lists by both male and female talkers. Participants with moderate-to-severe hearing loss scored 68% on average for the male talker Hmong lists and 60% on average for the female talker Hmong lists. Gender was significantly positively associated with average word recognition percent correct on the female word lists (b = -0.224, p = .047) but not statistically significant for the male word lists (b = 7.579, p = .141).
CONCLUSION: Findings provide support for the use of the four Hmong word lists in clinical settings.
Pembrolizumab will be given for two doses every 3 weeks starting on day 8 (ie days 8 and 29). Antibiotics will continue throughout the entire four week pre-operative period.
PURPOSE:To provide blood preparation producer of simple operation in which the blood is separated into individual components and the closed system can be maintain to produce various kinds of blood preparations. CONSTITUTION:The producer is shown in the figure and the closed circuit 21 is formed between the blood tank 10 for collected blood sample and treatment parts. A part of the closed circuit 21 is composed of the storing tank 10, the blood treatment unit 20 aseptically connectable to the tank 10 and the inlet 26 for introducing sterilized fluid into the closed circuit 21. The closed circuit preferably forms a recyclable path from the storing tank back to the tank and the germ-free conditions can be maintained without contact with the outer air and the circulation is continuously repeated. The means for fluid introduction is used for recovery of the blood in the closed system, particularly the treated blood in the treatment unit, into the storing tank. The germ-free fluid is preferably a gas.
One subcutaneous vaccination with a 10\^5 PFU dose of LGT(TP21)/DEN4 vaccine given in the deltoid region of either arm. A second booster vaccination will be given 6 months after the first vaccination. This arm may enroll after Arm 1 depending on the immunological response of Arm 1.
The invention provides an optical radiation resistant eye-protection traditional Chinese medicine buccal tablet, which includes the following components including, by weight, 5-10 parts of Arctium lappa L., 4-8 parts of cassia seed, 4-8 parts of mulberry, 4-8 parts of semen euryales, 5-10 parts of Poria cocos, 5-10 parts of chrysanthemum, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of fructus mume, and 5-10 parts of fructus lycii. The Arctium lappa L., the cassia seed, the mulberry, the semen euryales and the Poria cocos are added with purified water and decocted and concentrated. Ethanol is added and a mixture is deposited. The ethanol is removed and a first mixture is prepared. The chrysanthemum, the pericarpium citri reticulatae, the fructus mume, and the fructus lycii are added with the purified water and decocted and concentrated, and a second mixture is prepared. The first mixture and the second mixture are mixed uniformly with an accessory which may be cane sugar or lactose. A tablet machine is used to make tablets, and an aluminum-plastic blister machine is used for packaging. The optical radiation resistant eye-protection traditional Chinese medicine buccal tablet has the beneficial effect that the optical radiation resistant eye-protection traditional Chinese medicine buccal tablet performs traditional Chinese medicine conditioning on the eye damage from optical radiation, the symptoms and the root can be treated simultaneously, and the carry is convenient. The optical radiation resistant eye-protection traditional Chinese medicine buccal tablet is suitable for city white-collar workers facing computer screens for a long time.
Systems, methods, and compositions generate cross-linking activity for treatment of eye disorders. Various agents, additives, buffers, etc., may be employed in formulations with a cross-linking agent to enhance treatment. For example, a composition for applying treatment to a cornea of an eye includes a cross-linking agent that generates cross-linking activity in the cornea in response to exposure to a photo-activating light. The composition also includes an iron additive and citrate buffer. In some cases, the cross-linking agent may include riboflavin. In other cases, the iron additive may include FeSO 4 . In further cases, the iron additive may be dissolved in the citrate buffer.
Rifaximin will be initiated post-LT, once the subject is able to tolerate oral medications/diet. Rifaximin will be dosed at 550mg twice daily for 90 days (+/- 10 days) post-LT.
Anxiety is highly prevalent in individuals with ASD with lifelong impact. In this population, anxiety often emerges when children are very young, yet there are no evidence-based treatments for this age group. Cognitive-behavioral treatment (CBT) successfully reduces anxiety levels in young, typically developing children and older children with ASD. This study pilots the DINO Strategies for Anxiety and fear of Uncertainty Reduction (DINOSAUR) program, which is an integrated treatment program that utilizes CBT modified for young children with ASD. The treatment includes heavy doses of parent training to reduce accommodation of the child's anxiety symptoms and interventions targeting fear of uncertainty, a common fear in children with ASD. The feasibility, acceptability, and preliminary efficacy of this treatment program will be studied.
Human pluripotent stem cells (hPSCs) are a concrete source of hepatic cells for regenerative medicine applications and are largely contributing to the study of liver diseases, toxicity, and drug efficacy. However, hP SC-derived hepatocyte-like cells possess morphological and functional features typical of foetal hepatocytes rather than post-natal or adult hepatocytes. By self-assembling hepatic progenitors into spheroids and by refining the maturation step of their differentiation protocol, the inventors aim at generating hPSC-derived hepatocyte-like cells with an improved maturation degree, showing morphological and functional features of adult hepatocytes. More particularly, they adjusted the morphogen cocktail used for the maturation step by the regular administration of vitamin Kl, a daily regulation of glucocorticoid supply, and a progressive decrease of Oncostatin M (OSM) supply in the last days. They demonstrated that the hepatocytes produced with their protocol have reached the highly functional ability of primary human hepatocytes, an improved maturation stage compared to previously reported data on hPSC-derived hepatocytes. Thus the invention relates to a new method for improving the differentiation of hepatoblasts into hepatocytes.
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia is an ion channelopathy, caused by mutations in genes coding for calcium-handling proteins. It can coexist with left ventricular non-compaction. We aim to investigate the clinical and genetic characteristics of this co-phenotype.
METHODS: Medical records of 24 patients diagnosed with catecholaminergic polymorphic ventricular tachycardia in two Chinese hospitals between September, 2005, and January, 2020, were retrospectively reviewed. We evaluated their clinical and genetic characteristics, including basic demographic data, electrocardiogram parameters, medications and survival during follow-up, and their gene mutations. We did structural analysis for a novel variant ryanodine receptor 2-E4005V.
RESULTS: The patients included 19 with catecholaminergic polymorphic ventricular tachycardia mono-phenotype and 5 catecholaminergic polymorphic ventricular tachycardia-left ventricular non-compaction overlap patients. The median age of onset symptoms was 9.0 (8.0,13.5) years. Most patients (91.7%) had cardiac symptoms, and 50% had a family history of syncope. Overlap patients had lower peak heart rate and threshold heart rate for ventricular tachycardia and ventricular premature beat during the exercise stress test (p < 0.05). Sudden cardiac death risk may be higher in overlap patients during follow-up. Gene sequencing revealed 1 novel ryanodine receptor 2 missense mutation E4005V and 1 mutation previously unreported in catecholaminergic polymorphic ventricular tachycardia, but no left ventricular non-compaction-causing mutations were observed. In-silico analysis showed the novel mutation E4005V broke down the interaction between two charged residues.
CONCLUSIONS: Catecholaminergic polymorphic ventricular tachycardia overlapping with left ventricular non-compaction may lead to ventricular premature beat/ventricular tachycardia during exercise stress test at lower threshold heart rate than catecholaminergic polymorphic ventricular tachycardia alone; it may also indicate a worse prognosis and requires strict follow-up. ryanodine receptor 2 mutations disrupted interactions between residues and may interfere the function of ryanodine receptor 2.
Tart cherries are an excellent course of phenolic compounds and anthocyanins, and in pre-clinical studies have been shown to prevent age-related bone loss. Based on these findings, this pilot study was designed to investigate the effects of three months of tart cherry juice supplementation on improving markers of oxidative stress and bone metabolism in older women. Women (n=30), aged 65-80 yrs, will be recruited for the study and randomly assigned to one of two doses of tart cherry juice (8 or 16 fl oz) per day prepared from a Montmorency cherry concentrate (King Orchards, Central Lake, MI). Study participants will complete two study visits to the Nutritional Sciences Clinical Research Center. At the first visit, informed consent will be obtained and relevant medical history and anthropometric measures will be taken by the research team. A blood draw will be performed to assess baseline, biochemical markers of bone metabolism and inflammation as well as indicators of oxidative status. A physical activity and food frequency questionnaire will be completed by each study participant. Whole body, hip and spine bone density (DXA) scan will be performed by certified bone densitometrist. A 3-month final visit will be scheduled for all study participants in which most of the procedures described at baseline (except DXA) will be repeated. Change in primary and secondary outcome measures (i.e., bone, inflammation and oxidative stress biomarkers) will be assessed.
During standing CAP meetings, partnership investigators present their ongoing research to members of the CAPs. Researchers who receive U54 funding in the proposed renewal period including Full, Pilot, and Developmental projects can request CAP feedback on topics along the research continuum from concepts for new research projects, ideas for recruitment, or dissemination of fundings.
Prepn. of a mixt. of gangliosides comprises (a) subjecting ganglioside-contg. tissue to lipid elimination with acetone to produce an acetone ppte., (b) suspending the acetone ppte. in a first solvent mixt. (e.g. CH2Cl2, MeOH an NaOH) capable of partitioning hydrophobic substances from hydrophilic substances, (c) filtering the partitioning mixt. to obtain a first liquid phase, (d) subjecting the first liquid phase to pptn. (e.g. by adding CaCl2 and acetone) to obtain a first raw material, (e) solubilising the first raw material (using e.g. a mixt. of water, CHCl3 and MeOH) and subjecting the solubilised first raw material to heating at a pH of about 12, (f) subjecting the heated solubilised first raw material to a second partitioning in a second solvent mixt. (e.g. water, CHCl3 and n-butanol) capable of partitioning hydrophobic substances from hydrophilic substances, (g) sepg. the second partitioning mixt. to remove an organic phase and retain an aqs. phase, (h) subjecting the aqs. phase to pptn. (e.g. by adding acetone and NaCl) to produce a second raw material, (j) solubilising the third raw material in a base, e.g. 1N NaOH, (k) neutralising the solubilised third raw material and (l) subjecting the neutralised solubilised third raw material to dialysis through a membrane with a mol. wt. cut off of about 10 kD to produce a ganglioside mixt.. Also claimed is a ganglioside mixt. prepd. by the method.
It is unclear whether protein intake during dieting influences bone density. This information is important for determining optimal nutrient requirements during weight loss. This study will compare the effects of weight loss with a lower-carbohydrate, high-protein (HP) diet to a high-carbohydrate, moderate protein (HC) diet on bone mass and quality in postmenopausal women (ages 50-70 years) with the hypothesis that bone turnover and loss of bone will be reduced on the HP compared to the HC weight loss diet. In a secondary aim, we will examine bone markers, hormones and the impact of protein intake on diet quality.

Participants will be randomly assigned to one of 2 groups: A) weight loss with recommended level of protein intake, and B) weight loss with higher protein intake. All participants will attend regular counseling sessions (about 50 minutes per session) with a dietitian for approximately 1 year, and will be asked to take a daily vitamin/mineral supplement. Also, depending on their usual food intake, they may be asked to take a calcium tablet to meet the recommended intake throughout the study period. Bone, mineral, protein and lipid markers, and hormones that influence bones will be measured. These measurements will provide information about body composition (fat, muscle mass, and bone mineral density). Participants will be asked to attend 8 diet counseling sessions, with the opportunity to attend a total of approximately 28 diet counseling sessions during the year.
Disclosed are an adaptive recommendation apparatus for context aware-based physical activities and a method thereof. In this apparatus, a preference collection unit collects preferences for each situation and physical activity from a plurality of users. An integrated preference generation unit generates an integrated preference by integrating the preferences of the plurality of users for each situation and physical activity. A context information collection unit collects context information corresponding to the users. A cross-context-based recommendation unit generates cross-context preferences corresponding to the context information, which is collected by the preference collection unit, based on the preferences of the plurality of users for each situation and physical activity that correspond to the context information and the integrated preference that corresponds to the context information, and recommends, to the users, physical activities that are determined to be active in the generated cross-context preferences. Therefore, physical activities can be accurately recommended according to user preferences and context.
Massive overdosing or acute poisoning by ZYLOPRIM has not been reported.

In mice, the 50% lethal dose (LD50) is 160 mg/kg given intraperitoneally (IP) with deaths delayed up to 5 days and 700 mg/kg orally (PO) (approximately 140 times the usual human dose) with deaths delayed up to 3 days. In rats, the acute LD50 is 750 mg/kg IP and 6000 mg/kg PO (approximately 1200 times the human dose).

In the management of overdosage there is no specific antidote for ZYLOPRIM. There has been no clinical experience in the management of a patient who has taken massive amounts of ZYLOPRIM.

Both ZYLOPRIM and oxipurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of ZYLOPRIM is unknown.
As part of their treatment, lung cancer patients frequently endure thoracic oncological surgery, with preoperative chemotherapeutic interventions being the common approach. However, the potential impact of these chemotherapeutic regimens on cutaneous wound healing outcomes following surgery remains the topic of considerable clinical interest. This meta-analysis sought to evaluate comprehensively the effect of preoperative chemotherapeutic regimens on cutaneous wound healing in lung cancer patients following thoracic oncological surgery. Extensive literature searches were conducted using the leading databases PubMed, Embase, Cochrane Library and Scopus. Eight studies out of 1342 identified satisfied the inclusion criteria. Consideration was given to both randomized controlled trials (RCTs) and observational studies. Data pertaining to study characteristics, patient demographics, chemotherapeutic regimens and wound healing outcomes were extracted with great attention to detail. The examination of these varied studies provided insights into the fluctuations in rates of recovery following treatment, incidences of wound infections and frequencies of surgical complications. The research studies provided odds ratios for recovery that varied significantly in magnitude from 0.95 to 0.38, with regard to the probability of wound infection. Furthermore, a range of odds ratios for complications were disclosed, with certain odds ratios displaying narrow confidence intervals. The complexity of the effect of preoperative chemotherapy on wound closure subsequent to thoracic oncologic surgery is highlighted by our findings. The results underscore the need for individualized treatment strategies for lung cancer patients undergoing surgical procedures that strike a balance between patient safety and optimal clinical outcomes.