anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A pirfenidone sustained-release oral solid preparation, comprising a sustained-release preparation. The sustained-release preparation contains a swelling material, a shaping material and an adhesive material. The weight percentage of the swelling material in the solid preparation is 10-25%; the weight percentage of the shaping material in the solid preparation is 10-25%; and the weight percentage of the adhesive material in the solid preparation is 1-8%. The solid preparation only needs to be administered once per day, and there is no restriction on before or after meals. After administration, the solid preparation can quickly take effect, and stable and effective release can be achieved for 24 hours. The present solution provides a pirfenidone product having remarkably improved compliance and stable plasma concentration.
This is a multi-center, prospective, single-arm study, aimed to observe the safety and effectiveness of ImageReady™ MR conditional defibrillation system in a Chinese population.It will enroll 20 subjects in 5 sites in China.The primary safety endpoint is MR scan-related Complication-free rate between the MR Scan and the MRI + 1 Month Visit. The primary effectiveness endpoints include:1.Abnormal increase in RV shocking impedance from the pre-MR scan to the 1 Month post-MR scan. 2.Increase in RV pacing threshold from the pre-MR scan to the 1 Month post-MR scan. 3.Decrease in RV sensed amplitude from the pre-MR scan to the 1 Month post-MR scan. 4.Increase in LV pacing threshold from the pre-MR scan to the 1 Month post-MR scan. 5.Decrease in LV sensed amplitude from the pre-MR scan to the 1 Month post- MR scan.
The present invention relates to a drug delivery carrier comprising: (a) a ZZ domain; and (b) a targeting moiety which comprises the Fc site of an antibody and which binds to the ZZ domain for binding to a cell surface molecule. The drug delivery carrier can deliver drugs to a variety of cells by replacing only the targeting moiety, which can be achieved if the characteristics of a ZZ domain, which binds to the Fc site of an antibody (e.g. IgG), are employed to bind the ZZ domain to the targeting moiety (e.g. an antibody) which binds to a target cell surface substance (e.g. a receptor), and to thereby deliver the targeting moiety. Depending on the cargo to be transported, the drug delivery carrier of the present invention can be used in treatment of disease or illness, detection of specific cells, diagnosis of diseases (e.g. cancer), tracking of specific cells, and in-vivo imaging.
Efficient and effective workspace condition analysis systems and methods are presented. In one embodiment, a method comprises: accessing information associated with an activity space, including information on a newly discovered previously unmodeled entity; analyzing the activity information, including activity information associated with the previously unmodeled entity; forwarding feedback on the results of the analysis, including analysis results for the updated modeled information; and utilizing the feedback in a coordinated path plan check process. In one exemplary implementation the coordinated path plan check process comprises: creating a solid/CAD model including updated modeled information; simulating an activity including the updated modeled information; generating a coordinated path plan for entities in the activity space; and testing the coordinated path plan. The coordinated path plan check process can be a success. The analyzing can include automatic identification of potential collision points for a first actor, including potential collision points with the newly discovered object. The newly discovered previously unmodeled entity interferes with an actor from performing an activity. The newly discovered object is a portion of a tool component of a product.
Three doses of the vaccine will be administered, each with one month interval. RTS,S is a subunit vaccine that includes a portion of the circumsporozoite protein (CSP) co-expressed with Hepatitis B surface antigen. The adjuvant is AS01.
Bipolar disorder is a chronic mood disorder which is characterized by repetitive episodes, usually manifests through adolescence or early adulthood. It has a prevalence of approximately 2,5% with a 1:1 ratio of male and female. It is a disorder that may disrupt central nervous system functions such as cognition, thought, perception, affect, judgement, adaptation to the environment and behavioural regulation. It may manifest with various clinical onsets. Although etiology of bipolar disorder is still unknown, some biological factors such as BDNF, oxidative stress and structural changes of brain are proven to have a role in etiology.

Diffusion tensor magnetic resonance imaging (DTI) is a neuroimaging technique that elucidates abnormalities of brain white matter (WM), based on structural investigation of a tissue via measurement of diffusion rate and direction of water molecules. This method lets imaging of white matter tracts, whole anatomical extent and structural integrity of the brain tissue. So, it can provide data about anatomical connectivity of brain. There are some parameters used for indicating microstructural integrity of white mat-ter such as fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in DTI. FA is a measure which reflects directional coherence of water diffusion, and it is sen¬sitive to microstructural WM differences. It is defined on a scale ranging from mostly isotro¬pic (when approaching to zero) indicating poor integrity of the axons to mostly anisotropic (when approaching to 1) indicating intact WM integrity. ADC is a scalar index of the rate of water diffusion among different dif¬fusion directions under a Gaussian distribution. A higher value of ADC indicates lesser restricted diffusion, and it implies fewer organized structures in WM which supports presence of abnormalities in the structural in¬tegrity of white matter. As it has a complicated literature, in this study, we aimed to investigate neuronal integrity and its abnormalities by DTI, which may contribute to the etiology of bipolar depression.
This is a Phase 1, open-label, multicenter, dose escalation, and dose optimization study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of ZE46-0134 in adult patients with relapsed or refractory AML with FLT3-ITD and/or FLT3-TKD mutations. Patients with AML that are out-patients or hospitalized due to their AML can be enrolled in the study. The study will be run in 2 parts: Part 1 will be dose escalation and determination of the maximum tolerated dose, and Part 2 will be dose expansion.
INTRODUCTION: Chronic kidney disease (CKD) has always been a complicated global challenge, ranking as the 12th leading cause of death worldwide. Hemodialysis, being one of the most opted renal replacement therapies (RRTs) for patients with end-stage renal disease (ESRD), still possesses some limitations in preventing complications, such as malnutrition and mineral bone disease (CKD-MBD). While efforts have focused on controlling CKD-MBD parameters like calcium and phosphate, less attention has been given to dietary interventions. Moreover, the adoption of low-phosphorus diets for hemodialysis patients is very complex due to potential conflicts with the guideline-recommended high-protein dietary approach. This study sought to investigate the relationship between dietary phosphorus intake and nutritional status in CKD patients undergoing regular hemodialysis.
METHOD: This non-randomized cross-sectional study comprising 88 patients was conducted at the Hemodialysis Unit, RSUD Dr. Soetomo, Surabaya, East Java, using a three-day dietary record in March 2022. Relationships between variables were analyzed using Spearman and ANOVA tests.
RESULT: No significant positive association was found between dietary calcium with corrected calcium levels (p = 0.988; rs = -0.002) and between dietary phosphorus with plasma phosphate levels (p = 0.082; rs = 0.187). However, Spearman's analysis revealed a weak but positive correlation between dietary phosphorus and nutritional status (p = 0.022; rs = 0.215*).
CONCLUSION: Our study highlights a positive relationship between dietary phosphorus and nutritional status among hemodialysis patients, offering insights into potential strategies for optimizing patient care and outcomes.
Psychoeducational Group Intervention on Alcohol Drinking Related to Stress: Psychological group intervention with 3 sessions of 60 min (Odenwald \& Semrau, 2012). Contains psychoeducation on alcohol drinking related to stress and PTSD.
The present invention relates to correlating a position of a radiation beam with a position of a target to be irradiated which is contained in a structure having a repetitive motion comprising a plurality of successive motion cycles. External position data is acquired, which describes a position the structure during different motion cycles and/or time periods. Target data is acquired, which describe a position of the target during the motion cycles and/or time periods. A correlation model is generated, which correlates the external position and the target position. A predicted target position during a motion cycle is determined based on the correlation model and acquire external position data. Primary verification data is determined that describes an difference between actual and predicted target position. When the prediction is accurate, a further prediction and verification of the target position in later motion cycles can be performed.
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension contains hydrocodone, an opioid agonist; and chlorpheniramine, a histamine-1 (H1) receptor antagonist.

Each 5 mL of Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release (ER) Suspension contains hydrocodone polistirex equivalent to 10 mg of hydrocodone bitartrate and chlorpheniramine polistirex equivalent to 8 mg of chlorpheniramine maleate. Hydrocodone is a centrally-acting narcotic antitussive. Chlorpheniramine is an antihistamine.

Hydrocodone Polistirex and Chlorpheniramine Polistirex ER Suspension is for oral use only.

Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended-Release Suspension also contains the following inactive ingredients: Ascorbic acid, D&C Yellow No. 10, flavors, high fructose corn syrup, modified food starch, methylparaben, polysorbate 80, polyvinyl acetate, propylene glycol, propylparaben, purified water, sodium ascorbate, sodium metabisulfite, sodium polystyrene sulfonate, sucrose, triacetin, xanthan gum.

Hydrocodone Polistirex

The chemical name for hydrocodone, a centrally-acting narcotic antitussive, is 4,5α-epoxy-3-methoxy-17- methylmorphinan-6-one. Hydrocodone polistirex is a complex of sulfonated styrene-divinylbenzene copolymer. The molecular weight for hydrocodone and the polistirex resin is 298.364 g/mol and n x 315 g/mol- 1, respectively. The molecular formula for hydrocodone and the polistirex resin is C18H21NO3 and (C18SO3H19)n, respectively. It has the following structural formula:

Chlorpheniramine Polistirex

The chemical name for chlorpheniramine, an antihistamine, is 2-[p-chloro-α-[2-(dimethylamino)ethyl]- benzyl]pyridine. Chlorpheniramine polistirex is a complex of sulfonated styrene-divinylbenzene copolymer. The molecular weight for chlorpheniramine and the polistirex resin is 274.79 g/mol and n x 315 g/mol-1, respectively. The molecular formula for chlorpheniramine and the polistirex resin is C16N2H19Cl and (C18SO3H19)n, respectively. It has the following structural formula:
Document-level interaction extraction for Chemical-Disease is aimed at inferring the interaction relations between chemical entities and disease entities across multiple sentences. Compared with sentence-level relation extraction, document-level relation extraction can capture the associations between different entities throughout the entire document, which is found to be more practical for biomedical text information. However, current biomedical extraction methods mainly concentrate on sentence-level relation extraction, making it difficult to access the rich structural information contained in documents in practical application scenarios. We put forward SSGU-CD, a combined Semantic and Structural information Graph U-shaped network for document-level Chemical-Disease interaction extraction. This framework effectively stores document semantic and structure information as graphs and can fuse the original context information of documents. Using the framework, we propose a balanced combination of cross-entropy loss function to facilitate collaborative optimization among models with the aim of enhancing the ability to extract Chemical-Disease interaction relations. We evaluated SSGU-CD on the document-level relation extraction dataset CDR and BioRED, and the results demonstrate that the framework can significantly improve the extraction performance.
Age-Matched Healthy Controls will undergo MRI Brain and Spinal Cord. A subset will also be invited to undergo interval imaging at 3-6 months.
Athletes will undergo a 4-days sleep monitoring with the use of the Sleep Profler. At the same time, they will fill the Total Quality of Recovery (TQR) scale and the Pittsburgh Sleep Quality Index (PSQI).
Hip pain is a prevalent degenerative joint symptoms, imposing a significant global health burden. Hip pain is experiencing an increase in incidences in Korea due to its aging society, and the social burden of hip pain continues to rise as the hip joint is crucial for gait and balance. This study assessed the epidemiology of hip pain in Korea using data from the fifth version of Korea National Health and Nutrition Examination Survey (KNHANES V-5). The research analyzed data from 8,898,044 Koreans to evaluate the prevalence and characteristics of hip pain and abnormal hip X-ray. Variables encompassed medical, demographic, mental, social, and musculoskeletal factors. Descriptive analysis and propensity score matching analyses unveiled characteristics of Koreans experiencing hip pain or showing abnormal hip x-ray. The study provides insights into the epidemiology of hip pain in the entire Korean population, and further suggesting the effective management of hip pain.
The invention provides siRNA for specifically inhibiting chicken CTGF gene expression and application thereof. The sequences of the sense strand and the antisense strand of the siRNA are respectively shown as SEQ ID NO.1 and SEQ ID NO. 2. The CTGF target sequence of the siRNA interference is shown as SEQ ID NO. 3. The antisense strand of the siRNA molecule can be specifically combined with mRNA for inhibiting chicken CTGF gene to degrade the mRNA, thereby interfering the posttranscriptional translation process and promoting chicken preadipocyte differentiation. The siRNA provided by the invention has the advantages of high interference efficiency and good specificity on transcription level, high sensitivity, simple and convenient operation, short experimental period and low price compared with the gene knockout technology, and provides a direct and effective experimental tool for researching the functions and regulation mechanisms of the avian CTGF genes.
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors and responds to such changes remains unclear. Here, we describe a protective mechanism by which mucosal-associated invariant T (MAIT) cells detect microbiota metabolites produced upon intestinal inflammation and promote tissue repair. At steady state, MAIT ligands derived from the riboflavin biosynthesis pathway were produced by aerotolerant bacteria residing in the colonic mucosa. Experimental colitis triggered luminal expansion of riboflavin-producing bacteria, leading to increased production of MAIT ligands. Modulation of intestinal oxygen levels suggested a role for oxygen in inducing MAIT ligand production. MAIT ligands produced in the colon rapidly crossed the intestinal barrier and activated MAIT cells, which expressed tissue-repair genes and produced barrier-promoting mediators during colitis. Mice lacking MAIT cells were more susceptible to colitis and colitis-driven colorectal cancer. Thus, MAIT cells are sensitive to a bacterial metabolic pathway indicative of intestinal inflammation.
Intermediate filaments are one of three polymeric structures that form the cytoskeleton of epithelial cells. In the epithelium, these filaments are made up of a variety of keratin proteins. Intermediate filaments complete a wide range of functions in keratinocytes, including maintaining cell structure, cell growth, cell proliferation, cell migration, and more. Given that these functions are intimately associated with the carcinogenic process, and that hyperkeratinization is a quintessential feature of oral leukoplakias, the utility of keratins in oral leukoplakia is yet to be fully explored. This scoping review aims to outline the current knowledge founded on original studies on human tissues regarding the expression and utility of keratins as diagnostic, prognostic, and predictive biomarkers in oral leukoplakias. After using a search strategy developed for several scientific databases, namely, PubMed, Scopus, Web of Science, and OVID, 42 papers met the inclusion and exclusion criteria. One more article was added when it was identified through manually searching the list of references. The included papers were published between 1989 and 2024. Keratins 1-20 were investigated in the 43 included studies, and their expression was assessed in oral leukoplakia and dysplasia cases. Only five studies investigated the prognostic role of keratins in relation to malignant transformation. No studies evaluated keratins as a diagnostic adjunct or predictive tool. Evidence supports the idea that dysplasia disrupts the terminal differentiation pathway of primary keratins. Gain of keratin 17 expression and loss of keratin 13 were significantly observed in differentiated epithelial dysplasia. Also, the keratin 19 extension into suprabasal cells has been associated with the evolving features of dysplasia. The loss of keratin1/keratin 10 has been significantly associated with high-grade dysplasia. The prognostic value of cytokeratins has shown conflicting results, and further studies are required to ascertain their role in predicting the malignant transformation of oral leukoplakia.
Chronic rhinosinusitis (CRS) is a highly prevalent disease and up to 83% of CRS patients suffer from olfactory dysfunction (OD). Because OD is specifically seen in those CRS patients that present with a type 2 eosinophilic inflammation, it is believed that type 2 inflammatory mediators at the level of the olfactory epithelium are involved in the development of this olfactory loss. However, due to the difficulties in obtaining tissue from the olfactory epithelium, little is known about the true mechanisms of inflammatory OD. Thanks to the COVID-19 pandemic, interest in olfaction has been growing rapidly and several studies have been focusing on disease mechanisms of OD in inflammatory conditions. In this paper, we summarize the most recent data exploring the pathophysiological mechanisms underlying OD in CRS. We also review what is known about the potential capacity of olfactory recovery of the currently available treatments in those patients.
Despite the developments in the surgical field, the treatment of anal fistula is still a challenging problem, especially in complex, transsphincteric cases. The surgical treatment aims to avoid recurrences and also to preserve normal sphincter functions. The FiLaC procedure was recently reported non-invasive technique in perianal fistulas for treatment and preserving anal sphincter function with a good success rate. In 2018, one of our colleagues published a 40% complete healing rate by using only FiLaC technique in 103 consecutive perianal fistula patients (Prof. Cem Terzi). Some authors advocated that the closure of the internal orifice increasing the success rate. Therefore, the investigators decided to modify the surgical technique focusing closure of the internal opening associated with the FiLaC procedure.
The invention relates to a computer-implemented method for determining a similarity measure, the similarity measure describing a similarity between a first patient and a second patient. The method is based on receiving a first patient data record and a second patient data record, the first patient data record being assigned to the first patient and the second patient data record being assigned to the second patient.
Furthermore, a medical ontology is received or determined. In this context, the medical ontology is independent of the first patient data record and of the second patient data record. Furthermore, a patient ontology is determined on the basis of the medical ontology, and further on the basis of the first patient data record and/or the second patient data record. Furthermore, a similarity measure is determined on the basis of the patient ontology. Optionally, the similarity measure is moreover provided, the provision possibly encompassing storage, transmission and/or representation of the similarity measure. The invention furthermore relates to a determination system, a computer program product, and a computer-readable storage medium for determining a similarity measure, the similarity measure describing a similarity between a first patient and a second patient.
Chronic myeloid leukemia (CML), caused by BCR::ABL1 fusion gene, is known to regulate disease progression by altering the expression of genes. However, the molecular mechanisms underlying these changes are largely unknown. In this study, we identified RNA Exonuclease 5 (REXO5/LOC81691) as a novel gene with elevated mRNA expression levels in chronic myeloid leukemia (CML) patients. Additionally, using the REXO5 knockout (KO) K562 cell lines, we revealed a novel role for REXO5 in the DNA damage response (DDR). Compared to wild-type (WT) cells, REXO5 KO cells showed an accumulation of R-loops and increased DNA damage. We demonstrated that REXO5 translocates to sites of DNA damage through its RNA recognition motif (RRM) and selectively binds to R loops. Interestingly, we identified that REXO5 regulates R-loop levels by degrading mRNA within R-loop using its exonuclease domain. REXO5 KO showed ATR-CHK1 activation. Collectively, we demonstrated that REXO5 plays a key role in the physiological control of R-loops using its exonuclease domain. These findings may provide novel insights into how REXO5 expression changes contribute to CML pathogenesis.
The invention belongs to the field of biological pharmacy, and particularly relates to a cinnamon extract and a traditional Chinese medicine compound for preventing and treating cold injury and application thereof. The cinnamon extract comprises six compounds, and is prepared by firstly extracting crude cinnamon extract and then extracting the cinnamon extract in a refined manner. The cinnamon extract Chinese herbal compound I for preventing and treating cold injury comprises cinnamon, honey-fried licorice root, cortex acanthopanacis, radix puerariae, caulis spatholobi, fructus evodiae, radix codonopsitis, rhizoma zingiberis, cassia twig and cinnamon extract; is prepared by mixing the medicinal liquids of ethanol extraction and liquid-phase water extraction, concentrating, and adding cortex Cinnamomi extract. Cortex Cinnamomi extract Chinese medicinal composition II comprises Zingiberis rhizoma, cortex Cinnamomi, and cortex Cinnamomi extract; cortex Cinnamomi extract Chinese medicinal composition III comprises cortex Cinnamomi, radix Paeoniae alba, and cortex Cinnamomi extract; the compound Chinese medicinal materials include cortex Cinnamomi, Glycyrrhrizae radix, and cortex Cinnamomi extract. The cinnamon extract can be used for preparing medicines for increasing heat production of organisms and preventing cold injury. The Chinese herbal compound can be used for preparing a medicament for improving energy metabolism and preventing and/or treating metabolic syndrome.