anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Inflammation involving adipose macrophages is an important inducer of obesity. Regulating macrophages polarization and improving the inflammatory microenvironment of adipose tissue is a new strategy for the treatment of obesity. An amphiphilic chondroitin sulfate phenylborate derivative (CS-PBE) was obtained by modifying the main chain of chondroitin sulfate with the hydrophobic small molecule phenylborate. Using CS-PBE self-assembly, macrophage targeting, reactive oxygen species (ROS) release and celastrol (CLT) encapsulation were achieved. The cytotoxicity, cellular uptake, internalization pathways and transmembrane transport efficiency of CS-PBE micelles were studied in Caco-2 and RAW264.7 cells. Hemolysis and organotoxicity tests were performed to assess the safety of the platform, while its therapeutic efficacy was investigated in high-fat diet-induced obese mice. Multifunctional micelles with macrophage targeting and ROS clearance capabilities were developed to improve the efficacy of CLT in treating obesity.In vitrostudies indicated that CS-PBE micelles had better ability to target M1 macrophages, better protective effects on mitochondrial function, better ability to reduce the number of LPS-stimulated M1 macrophages, better ability to reduce the number of M2 macrophages, and better ability to scavenge ROS in inflammatory macrophages.In vivostudies have shown that CS-PBE micelles improve inflammation and significantly reduce toxicity of CLT in the treatment of obesity. In summary, CS-PBE micelles could significantly improve the ability to target inflammatory macrophages and scavenge ROS in adipose tissue to alleviate inflammation, suggesting that CS-PBE micelles are a highly promising approach for the treatment of obesity.
The use of a cardiac glycoside and/or a diuretic in a solvent or carrier in the formulation of pharmaceutical composition for the therapeutic treatment of neuropathic pain. The cardiac glycoside is selected from digoxin, digitoxin, ouabain, strophanthia, but preferably is digoxin. The diuretic is a loop diuretic, thiazide diuretic or sulphonyl urea, but preferably is furosemide. The carrier is preferably a topical medicament, and is in the form of a gel, a patch, lacquer or paint. Also claimed is a method of manufacturing a gel based composition comprising mixing propylene glycol, ethanol and water, adding cardiac glycoside and/or diuretic to excess, and then adding a gelling agent to the saturated solution. The gelling agent is preferably hydroxypropylcellulose.
Colonic cleansing through 3 interventions of Modern Colon Hydrotherapy. In addition, a daily intake of a placebo for 30 days.
Upon exposure to UVB, the epidermal component trans-urocanic acid is not only photoisomerized into cis-urocanic acid, but will also, at least in part, be photooxidized into urocanic acid oxidation products. We hypothesized that urocanic acid oxidation products can mimic UV-induced systemic immunosuppression comparable to the suppressive properties already established for cis-urocanic acid. A crude mixture of urocanic acid oxidation products showed a significant suppression of the sensitization phase of the systemic contact hypersensitivity response to picryl chloride. Three of the urocanic acid oxidation products were selected for this study: imidazole-4-carboxylic acid, imidazole-4-carboxaldehyde and imidazole-4-acetic acid. Effects on the sensitization-, elicitation- and post-elicitation phase of contact hypersensitivity to picryl chloride in BALB/c mice were studied and compared to the effects of cis-urocanic acid. Imidazole-4-carboxaldehyde was equally effective at suppressing the sensitization phase as cis-urocanic acid. The triplet combination of the imidazoles showed more pronounced suppression than that induced by cis-urocanic acid. The most effective compounds for the suppression of the elicitation phase appeared to be imidazole-4-acetic acid and cis-urocanic acid. Significant suppression of the post-elicitation phase was only obtained with the triplet combination of imidazole-4-carboxaldehyde, imidazole-4-carboxylic acid and imidazole-4-acetic acid, which combination appeared to be effective at all three tested phases, Because these three urocanic acid oxidation products are present in UVB-exposed human stratum corneum, these compounds may play a role in UVB-induced immunosuppression.
Swallowing refers to the process by which food enters the stomach from the mouth. It is the physiological mechanism by which humans take in water and nutrients. It is a vital activity for individual survival. The physiological mechanism of swallowing has four major stages, oral preparation, oral cavity, pharynx, and esophagus. Each stage has its physiological mechanism, which depends on the different nerve and muscle structures. In the oral stage, our tongue plays an important role. Whether in the formation or transition of the food bolus, it must rely on the tongue to perform its normal functions. The main topic of the research is to explore the strength of the tongue when swallowing. The purpose is to discuss the influence of gender and age on swallowing tongue pressure. We expect to recruit 80 subjects and divide them into three groups according to their age: 20 to 39 years old, 40 to 59 years old, and 60 to 79 years old, with 13 to 14 males and females in each group, using Iowa Oral Performance Instrument measures the subject's maximum tongue pressure, average swallowing tongue pressure, and the ratio of the maximum tongue pressure used when swallowing, to explore whether age and gender affect tongue strength when swallowing.
Tai chi elements in incorporated into the exercise component of standard pulmonary rehabilitation program. The exercise content was totally identical to the PRP group except 15 minutes of Tai Chi exercises was substituted to 15 minutes of relaxation exercise. The 5 forms of Sun Style of Tai Chi were taught.
PCT No. PCT/EP93/01661 Sec. 371 Date Mar. 28, 1994 Sec. 102(e) Date Mar. 28, 1994 PCT Filed Jun. 28, 1993 PCT Pub. No. WO94/03595 PCT Pub. Date Feb. 17, 1994The present invention is concerned with a genetically modified live herpesvirus vaccine of which the live herpesviruses are not shed into the environment by a vaccinated animal. This can he achieved by deleting a gene encoding a gD homolog, such as gp50 of pseudorabies virus, and propagating this deletion mutant in a cell line expressing the gene product. The reduced shedding characteristic of such a vaccine is particularly advantageous in a vector vaccine. The present invention also concerns a quadruple mutant pseudorabies virus vaccine, and a live cell bound vaccine containing gp50 mutant pseudorabies virus and cells which do not complement the mutation.
Excessive neointimal hyperplasia (NIH) of coronary vessels in patients is the main cause of restenosis (RS) after percutaneous coronary intervention (PCI). This study aimed to identify the regulatory genes related to NIH in a rat carotid artery balloon injury model.We established a rat model and performed RNA sequencing to identify differentially expressed long non-coding RNAs (DElncRNAs) and differentially expressed message RNAs (DEmRNAs). Immune cells were analyzed using a murine Microenvironment Cell Population counter. The Pearson correlation between DEmRNAs, DElncRNAs, and immune cells was analyzed, followed by function enrichment analysis. Core DEmRNA was identified using Cytoscape. Next, a core lncRNAs-mRNAs-immune cell regulatory network was constructed. NIH-related gene sets from the Gene Expression Omnibus and GeneCards databases were used for validation.A total of 2,165 DEmRNAs and 705 DElncRNAs were identified in rat carotid artery tissue. Four key immune cells were screened out, including mast cells, vessels, endothelial cells, and fibroblasts. Based on the Pearson correlation between DEmRNAs, DElncRNAs and 4 key immune cells, 246 DEmRNAs and 93 DElncRNAs were obtained. DEmRNAs that interact with lncRNAs were mainly involved in the cell cycle, MAPK signaling pathway, and PI3K-Akt signaling pathway. A core lncRNA-mRNA-immune cell regulatory network was constructed, including 9 mRNAs, 4 lncRNAs, and fibroblasts. External datasets validation confirmed the significant correlation of both these mRNAs and lncRNAs with NIH.In this study, an lncRNA-mRNA-immune cell regulatory network related to NIH was constructed, which provided clues for exploring the potential mechanism of RS in cardiovascular diseases.
Purpose: To investigate the impact of animal-assisted activity (AAA) involving a dog (play therapy) on reducing the pain experienced by children during the administration of local anesthetic (LA). Methods: Children between the ages of eight and 12 years who required LA administration were randomized into an AAA group and a control group. Baseline data for the simplified Modified Child Dental Anxiety Scale-Faces version (MCDAS[f]) was recorded, followed by the implementation of either AAA with standard care or standard care alone. The conventional protocol was followed for the administration of LA. Procedural pain was evaluated using both the Faces Pain Scale-Revised (FPS-R) and the Faces, Legs, Activity, Cry, and Consolability Scale (FLACC). All variations in pulse were also recorded. After the procedure, a simplified MCDAS(f) was recorded once again. The data were tabulated and statistically analyzed. Results: The children in the AAA group reported lower pain scores, as measured by FPS-R, compared to the control group (P =0.009). Pain, as observed in the FLACC scores, was also low in the experimental group (P <0.001). A notable reduction in anxiety scores (P <0.001) was observed among children assigned to the AAA group. Conclusion: AAA involving a dog led to a reduction in the pain experienced by children undergoing LA administration, subsequently decreasing anxiety.
PURPOSE:The titled dental tape, obtained by forming an application layer on the undersurface of a drug-containing layer obtained by applying and impregnating the upper layer of a sheetlike support with a dentifrice component, convenient for portable use, simply usable, and having dentifrice effect almost equal to that of a toothbrush. CONSTITUTION:A dental tape obtained by applying and impregnating the upper layer of a sheetlike support 2 partially or wholly with a dentifrice component 3 to form a drug-containing layer 1, and forming an application layer 6 on the undersurface of the above-mentioned drug-containing layer 1. In use, the above- mentioned application layer 6 is applied to a finger 5 to wet the drug-containing layer 1 with water, and the finger 5 is used in place of a toothbrush. Thus, teeth or gingivae can be easily and precisely polished and cleaned to give the dentifrice effect almost equal to that of a toothbrush. The upper layer of the drug-containing layer 1 is covered with a surface protective sheet 7, and a release layer 8 is applied to the undersurface of the application layer. Therefore, the cleaning of the interior of the oral cavity can be easily carried out by the sanitary tape convenient for portable use regardless of the place.
Breast cancer (BC) is the most frequent neoplasm in women; the lifetime probability of developing invasive breast cancer is estimated to be 12.8%. Ovarian cancer (OC) represents the second most common type of gynecologic neoplasm, with an incidence of about 1.5%. A sedentary lifestyle and being overweight seem to play a role in the development of these diseases; an increase in body mass index (BMI) of 5 units is correlated with a 12% increased risk of developing BC and 7-10% increased risk of developing OC. Exposure to environmental toxic factors, such as Cadmium (Cd), has also been found to play a role in the development of BC and OC. Indeed, it has been shown that Cd is involved in the pathogenesis of these neoplasms as it would act as an endocrine disruptor: through binding to the estrogen receptor it would determine its activation thereby promoting cell proliferation. Cd is released into the soil, water and air from natural sources but, most importantly, as a result of industrial processing the processing of nonferrous metals, the production of batteries and paints, the production and application of phosphate-based artificial fertilizers, the use of coal and petroleum, incineration and waste disposal. The general population may be exposed to Cd through: contaminated food and drinking water; cigarette smoking (active and passive), as tobacco leaves accumulate Cd from the soil; and inhalation of dust and fumes, especially for people living near industries that process or emit Cd. At the same time, it is well known that genetic factors are also related to the pathogenesis of BC and OC. In about 20% of patients with triple-negative BC and 20-25% of women with high-grade serous OC, a pathogenetic variant of these genes can be found. In subjects carrying constitutional pathogenetic variants (VPs) in the BRCA1/2 (BRCA1/2m) genes, the absence of repair of damage to the DNA double helix causes its accumulation favoring the development of neoplasms. This results in individuals carrying these variants having a cumulative risk of developing BC of 72% in the case of BRCA1 and 62% in the case of BRCA2. With regard to OC, the risk associated with the presence of VP in the case of BRCA1 is 44% and 17% in the case of BRCA2. These observations are consistent with the hypothesis that genetic risk related to cancer development is modified by environmental or other molecular factors. Several studies have evaluated factors such as lifestyle, overweight, weight gain, and physical inactivity as potential risk elements of BC or OC in BRCA1/2m mutation carriers. The aim of this study is to evaluate the possible interference of environmental factors in the development of BC or OC in women VP carriers of BRCA 1 and BRCA 2
The invention discloses a fusion interferon and application thereof in preparation of a mucosal immunopotentiator. The invention firstly provides a protein, which comprises the following two sections: porcine PoIFN λ 1 protein and porcine IL2 protein. The protein also includes a linker peptide between the porcine PoIFN λ 1 protein and the porcine IL2 protein. The invention also protects the application of the protein in preparing the vaccine for the porcine viral infectious diseases. The invention also protects a vaccine for porcine viral infectious diseases, which comprises the protein. The invention has great application and popularization value for preventing and controlling the porcine viral infectious diseases.
PURPOSE: This study aimed to develop machine learning algorithms for identifying predictive factors associated with the risk of postoperative surgical site infection in patients with lower extremity fractures.
METHODS: A machine learning analysis was conducted on a dataset comprising 1,579 patients who underwent surgical fixation for lower extremity fractures to create a predictive model for risk stratification of postoperative surgical site infection. We evaluated different clinical and demographic variables to train four machine learning models (neural networks, boosted generalised linear model, naïve bayes, and penalised discriminant analysis). Performance was measured by the area under the curve score, Youdon's index and Brier score. A multivariate adaptive regression splines (MARS) was used to optimise predictor selection.
RESULTS: The final model consisted of five predictors. (1) Operating room time, (2) ankle region, (3) open injury, (4) body mass index, and (5) age. The best-performing machine learning algorithm demonstrated a promising predictive performance, with an area under the ROC curve, Youdon's index, and Brier score of 77.8%, 62.5%, and 5.1%-5.6%, respectively.
CONCLUSION: The proposed predictive model not only assists surgeons in determining high-risk factors for surgical site infections but also empowers patients to closely monitor these factors and take proactive measures to prevent complications. Furthermore, by considering the identified predictors, this model can serve as a reference for implementing preventive measures and reducing postoperative complications, ultimately enhancing patient outcomes. However, further investigations involving larger datasets and external validations are required to confirm the reliability and applicability of our model.
This invention relates to the preparation of liposomes with hydrophobic proteins. L-asparaginase (L-ASNase - l-asparagine amido hydrolase E.C.3.5.1.1.) is a protein with therapeutic action in the treatment of acute lymphoblastic leukaemias in human beings.  Its use is limited, however, by the severe side effects, principally acute allergic reactions which in some cases can go as far as anaphylactic shock and even death. Liposomes have been used as vehicles for transport of L- ASNase and have shown evidence of protecting against said allergic reactions.  The efficiency of encapsulation of the formulations developed hitherto, however, is low. With the development of a new derivative of L-ASNase, palmitoyl-L-ASNase, it has become possible to incorporate it into the lipid matrix of liposomes, increasing the activity of these vehicles while they remain in circulation in intact form.  The objective of this invention was to obtain a process for preparation of liposomes which would lead to palmitoyl-L-ASNase liposomal formulations with high encapsulation efficiency, maximum stable activity while in circulation in the blood, and high antitumoral activity.  This new preparation process can also be used in many other situations with other enzymes and drugs in which the same aims are sought. The present invention is based on the addition of freeze- dried hydrophobic protein to preformed liposomes, followed by a freeze-drying process.  After this the powder obtained is dissolved (hydration) and passed through polycarbonate filters, under nitrogen flow pressure.  The principal inventive characteristics of the process are the addition of empty multilamellar liposomes to modified freeze-dried protein and also the introduction of a step involving density gradient ultracentrifugation followed by another ultracentrifugation, the first with the aim of separating the protein not incorporated in the liposomes and the second with the aim of eliminating the gradient constituent from the final working medium.
The process comprises reaction of isobutyrophenone with sodamide and then with 1,3-dibromo-propane in aromatic hydrocarbon, e.g. benzene, for addition of water to give intermediate cpd. of formula (II). This cpd. is distilled for reaction with 2,5-dimethyl phenol in aq. soln. of e.g. an alkali hydroxide, to give a cpd. of formula (II) - This latter is then distilled, and reacted with excess of potassium tert.-butoxide in anisole at 150 deg.C, to give product of formula (I).
The present invention relates to the treatment of type 2 inflammation. Based on the role of ILC2 in the induction of airway inflammation, the inventors investigate whether ILC2 could be influenced by sex hormones. In this study (effected on mice), they have unravelled a novel level of regulation of ILC2 responses. Analysis of multiple tissues from both sexes revealed a significantly increased presence of ILC2 in females compared with males. Interestingly, this difference was not due to an enhancing effect of estrogens in females, but rather to the inhibition of ILC2 development in males mediated by androgens through androgen receptor expression within the hematopoietic compartment. As a consequence, females developed exacerbated lung inflammation in response to house dust mite (HDM) extract or to IL-33 administration. These results demonstrate the interest of androgen receptor as a target on ILC2. Thus, the invention relates to an agonist of the androgen receptor express on group 2 innate lymphoid cells (ILC2) for use in the treatment of type 2 inflammation in a subject in need thereof.
The control group (I): The participants will follow the traditional pulmonary rehabilitation program including (active cycle of breathing technique, breathing control, deep breathing exercises, huffing). The session duration will be between 30 min twice/day for 15 days as guided by subject fatigue and comfort. (According to Borg scale of dyspnea for monitoring).
PURPOSE: A composition containing Gentiana scabra var. buergeri max extract is provided to reduce c-Fos expression and to prevent drug addiction. CONSTITUTION: A pharmaceutical composition for preventing and treating drug addiction contains 0.01-50 weight% of Gentiana scabra var. buergeri max extract as an active ingredient. The Gentiana scabra var. buergeri max extract is isolated using water, low alcohol of C1-C4, or mixture solvent thereof. A health food for preventing and treating drug addiction contains Gentiana scabra var. buergeri max extract as an active ingredient. The health food is manufactured in the form of powder, granule, tablet, capsule, syrup, or beverage.
The original MCT intervention was adapted to negative symptoms by incorporating psychoeducation and strategies to target the cognitions suggested by the cognitive model (Beck et al., 2009) to be implicated in the development and/or maintenance of negative symptoms. Although some of the strategies have traditionally been used to target positive symptoms, it is assumed that the same reasoning styles lead to negative symptoms through the dysfunctional cognitions discussed previously (e.g., jumping to conclusions in regard to social rejection and a dysfunctional attribution style reinforcing social withdrawal). Metacognitive training for negative symptoms consists of eight sessions, delivered individually as there is evidence indicating that this approach may lead to stronger effect sizes than delivery in a group format (Liu et al., 2018). The developer of MCT (Professor Steffen Moritz) approved the modification.
Written educational material was sent to individuals in the control group. Patient Descriptive Characteristics Form, S³-NIV Questionnaire and Insomnia Severity Index scales will be applied as pre-test data to the control group, which is not given any training other than written material. During the 8-week period, the scales will be applied to the control group again in the 4th week and the 8th week. After the 8th week data collection, web-based "NIV Survival Training" will also be given to individuals in the control group.
During sleep, while lying in supine position, the participant will be tilted sidewards by the bed. In practice, the experimenter activates the bed at timepoints during the night where the participant is lying in supine position. Activating the bed results in one half of the bed lifting 10 to 40 Degrees sidewards.
The present invention relates to the process of preparing a stable fixed dose composition of anti-infective agent with micro organism as active ingredients. The process includes preparation of various dosage forms for oral route like capsule, tablet and liquid formulation. The process comprises providing an appropriate barrier by way of selected coating procedure to one of the active ingredients in such a way that micro organisms are not affected by anti-infective agetns. This results in a stable composition. The ratio of micro organism to anti-infective agents in a composition can be 1:2 to 1:25 by weight. The amount of coating is dependent on the type of coating technique, dosage form i.e. capsule, tablet or liquid and desired self life. The compositions eliminate gastro intestinal disturbances associated with anti-infective agents. The anti-infective agent may be ampicillin, amoxycillin, cloxacillin cephalexin, cefuroxime or cefixime and the micro organism is preferably a Lacto bacillus.
Dasatinib (D) is given as (1) 100mg capsule daily for 2 consecutive days (Sprycel®, Bristol Myers Squibb). Quercetin (Q) will be given as (4) 250 mg capsules daily (total 1000 mg daily) for the same 2 consecutive days (Thorne Research). Both are administered orally.