anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: cosmetic industry; may be used as creams for skin care (day and night) and cosmetic masks. SUBSTANCE: cosmetic maricream includes gel-forming base, sodium salt of desoxyribonucleic acid prepared from fish milt, biologically active substances of vegetable and animal origin. Used as sodium salt of desoxyribonucleic acid is fragmentated acid prepared from milt of salmon family fish with average mol.m. not less 0.1MD. Composition has the following ratio of components, mas.%: sodium salt of desoxyribonucleic acid received from milt of salmon family fish with mol.m. not less 0.1MD, 0.05-0.3; base with biologically active substances of vegetable and animal origin, up to 100%. EFFECT: higher absorption through epiderma. 3 cl, 1 tbl
After 2 days of up-titration, participants who received FK949E 150 mg once daily at bedtime for 8 weeks in Treatment Period I and were evaluated against the transition criteria to transfer to Treatment Period II. If transition criteria were not met, participants underwent to a dose-tapering period (1 week) and a follow-up period (1 week) thereafter. If transition criteria were met, participants went into Treatment Period II.
Abacavir Oral Solution USP: It is a clear to opalescent, yellowish, strawberry-banana-flavored liquid. Each mL of the solution contains abacavir sulfate USP equivalent to 20 mg of abacavir. It is packaged in opaque bottles with child-resistant closure. This product does not require reconstitution.

  


Bottles of 240 mL NDC 65862-089-24

  


Store at 20° to 25°C (68° to 77°F). [see USP Controlled Room Temperature]. DO NOT FREEZE. May be refrigerated.
Patients will receive sirukumab 50 mg SC at Weeks 0, 4, and every 4 weeks through Week 52. Between sirukumab injections, placebo SC administrations will be made at Weeks 2, 6, and every 4 weeks through Week 52.
The invention discloses a Chinese medicinal composition for treating nephrotic azotemia, which belongs to the field of Chinese medicaments. The Chinese medicinal composition comprises the following twelve medicaments: fineleaf schizonepeta herb, divaricate saposhnikovia root, garden burnet root, red paeony root, radix salviae miltiorrhizae, India madder root, scorch-fried crataegus, fructus polygoni orientalis, reed rhizoma; common cephalanoplos herb, areca peel, and areca seed. The red paeony root, the radix salviae miltiorrhizae and the scorch-fried crataegus are ground into fine powder forstandby; and the rest nine medicaments are soaked by water and then decocted for 2 hours, the residual liquor is filtered, and the filter residue is added with water and is boiled for 1 hour and thenis filtered. The decoction is mixed, decompressed and concentrated into thick paste. The fine powder is added into the thick paste for uniform mixing. The mixture is dried and ground at a low temperature and then is packed into capsules. The Chinese medicinal composition has the effects of clearing away heat and dampness, cooling blood and dissolving stasis, dredging fu-organs and eliminating turbid, detoxicating and resolving mass, and eliminating slough and promoting a new system. The Chinese medicinal composition is suitable for azotemia caused by various kidney diseases and has excellent effect.
Poverty alleviation remains an urgent issue in China's rural areas, with health poverty being a critical dimension. This study analyzed the multidimensional health poverty status of 9,052 rural residents in Ningxia in 2019 and 7,910 in 2022, aiming to provide a reference for optimizing health poverty alleviation strategies. The A-F dual cutoff method was used to identify and measure multidimensional health poverty through dimensions such as health status, health service utilization capacity poverty, and health spending and security poverty. Logistic regression analysis was further applied to examine the influencing factors of multidimensional health poverty. The results indicate that when the k-value is set at 0.3, the incidence of multidimensional health poverty was 22.3% in 2019 and 7.7% in 2022. The corresponding multidimensional health poverty indices were 0.091 and 0.028, respectively. Furthermore, the level of multidimensional health poverty was higher among women than men. Chronic diseases were identified as a significant indicator of multidimensional health poverty. At the individual level, gender, age, education, government subsidies, family size, housing, and digital divide significantly effected health poverty. Although multidimensional health poverty has improved in rural northwest China, targeted measures remain essential, especially for rural women, individuals with chronic illnesses, and those facing challenges in accessing healthcare and digital connectivity. Sustainable multidimensional health poverty alleviation should prioritize remote rural areas, especially by enhancing healthcare resource utilization for rural women and individuals with chronic diseases. Additionally, increasing medical subsidies for marginalized groups is essential. Improving rural housing conditions, strengthening digital infrastructure, and raising digital health literacy are also critical steps.
PURPOSE:To obtain a novel, safe peptide having opioid activity such as anes thetic or analgesic activity from a hydrolyzate prepared by hydrolyzing wheat protein with an acidic protease followed by further hydrolysis with a neutral or alkaline protease. CONSTITUTION:Firstly, wheat protein is hydrolyzed with an acidic protease (e.g. aspartic proteinase of Aspergillus origin) followed by further hydrolysis with a neutral protease (pref. thermolysin) or alkaline protease (pref. serine protease of Bacillus origin). Then, the resulting hydrolyzate is fractionated pref. by reversed-phase chromatography using high-performance liquid chromatography to obtain the objective peptide. The amount of each of the above proteases to be used is pref. 5000-100000 units per 100 g of dry gluten. The objective peptide is e.g. of formula I or II.
BACKGROUND AND STUDY AIMS: Endoscopic submucosal excavation (ESE) and endoscopic full-thickness resection (EFTR) are common endoscopic minimally invasive methods for treatment of gastric submucosal tumors (SMTs). However, it is sometimes difficult to expose the tumor optimally. This study aimed to explore the safety and effectiveness of tumor traction using orthodontic rubber band (ORB) combined with clips to assist ESE and EFTR of gastric SMTs.
PATIENTS AND METHODS: The data of patients with gastric SMTs who underwent ESE or EFR at the Endoscopy Center of the 900th Hospital of PLA from January 2021 to May 2022 were retrospectively analyzed. Baseline characteristics and clinical outcomes, including operation time and postoperative adverse events, were compared between patients receiving ORB-ESE/EFTR and conventional ESE/EFTR.
RESULTS: A total of 52 patients were enrolled: 16 patients who underwent ORB-ESE /EFTR and 36 patients who underwent conventional ESE/EFTR. Median procedure time was significantly shorter in the ORB-ESE/EFTR group than in the conventional ESE/EFTR group (32 [IQR, 23.8, 38.0] minutes vs. 39.0 [IQR, 34.6-67.3] minutes, P = 0.002). Baseline characteristics, en bloc resection rate, incidence of postoperative adverse events, and postoperative pathology results were comparable between the two groups (P > 0.05).
CONCLUSION: Use of ORB with clips-assisted traction during ESE/EFTR of gastric SMT can shorten the surgical time. Further large prospective studies are needed to confirm the findings of this study.
A system and method for tracking and monitoring persons. To begin, the presence of a user at a location is determined when the userID is identified in the primary input data. The user's motion are determined using the primary input data and the secondary input data when the presence of the user at the location is determined. The position of the user is determined using the secondary input data when the presence of the user is determined. A matching algorithm is used to identify reference data that is similar to the primary input data or secondary input data and thereby determines completion of a user task of the user. transmit, via a communications device communicatively coupled to the control circuit, a notification is transmitted to a user computing device for conveyance via the user interface when completion of the user task is determined.
OBJECTIVE: In this study, we aimed to evaluate the combined diagnostic value of procalcitonin (PCT), C-reactive protein (CRP), and serum amyloid A (SAA) in sepsis caused by urinary tract infection.
METHOD: A total of 80 patients with urosepsis who were hospitalized were included in the study group, and 80 patients with urinary tract infection without sepsis were included in the control group. We collected the PCT, SAA, and CRP levels of patients following admission. Subsequently, we conducted a comparative analysis to assess the specificity, accuracy, and sensitivity of combined diagnostic approaches in contrast to individual diagnostic methods for blood PCT, SAA, and CRP.
RESULTS: The levels of PCT, SAA, and CRP in the study group were significantly higher than those in the control group, and the differences were statistically significant (P < 0.01). Multi-factor logistic regression analysis revealed that the levels of PCT (P = 0.003) and SAA (P = 0.014) were associated with urosepsis. The sensitivity of PCT was 87.133% and the specificity was 93.066%, which were higher than that of SAA and CRP. The specificity of the combined detection of the three was 95.670%, which was higher than that of PCT, SAA, and CRP alone. Correlation analysis revealed that PCT had a significant positive correlation with CRP and SAA (P < 0.01), and a weak correlation with white blood cell count (WBC) and fibrinogen (FIB) (P = 0.03 for WBC, P = 0.04 for FIB).
CONCLUSION: PCT, SAA, and CRP indicators in patients with urosepsis are significantly elevated, and all three are valuable in the diagnosis of urosepsis. PCT alone has good diagnostic efficiency for urosepsis, and a certain correlation with other inflammatory factors. The diagnostic efficacy of the three indicators in combination is better than that of any one of the three, and is worthy of widespread clinical application.
To determine the effect of augmenting serotonin A1 receptor activity on breathing during sleep. The investigators hypothesize that administration of PAP and buspirone, a serotonin A1 receptor agonist; will reduce the propensity to central apnea during sleep in Veterans with CSA compared to PAP plus placebo.
Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. 

Average and large doses of cortisone or hydrocortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Patients with a stressed myocardium should be observed carefully and the drug administered slowly since premature ventricular contractions may occur with rapid administration. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. 

While on corticosteroid therapy patients should not be vaccinated against smallpox. Other immunization procedures should not be undertaken in patients who are on corticosteroids, especially in high doses, because of possible hazards of neurological complications and lack of antibody response. 

The use of dexamethasone sodium phosphate injection in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate anti-tuberculosis regimen. 

If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis. 

Because rare instances of anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any drug.
Participants receive anetumab ravtansine IV over 60 minutes and atezolizumab IV over 30-60 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Primary graft dysfunction (PGD) is a severe form of acute lung injury resulting from lung ischemia/reperfusion injury (I/R) in lung transplantation (LTx), associated with elevated post-transplant morbidity and mortality rates. Neutrophils infiltrating during reperfusion are identified as pivotal contributors to lung I/R injury by releasing excessive neutrophil extracellular traps (NETs) via NETosis. While alveolar macrophages (AMs) are involved in regulating neutrophil chemotaxis and infiltration, their role in NETosis during lung I/R remains inadequately elucidated. Extracellular histones constitute the main structure of NETs and can activate AMs. In this study, we confirmed the significant involvement of extracellular histone-induced M1 phenotype of AMs (M1-AMs) in driving NETosis during lung I/R. Using secretome analysis, public protein databases, and transwell co-culture models of AMs and neutrophils, we identified Cathepsin C (CTSC) derived from AMs as a major mediator in NETosis. Further elucidating the molecular mechanisms, we found that CTSC induced NETosis through a pathway dependent on NADPH oxidase-mediated production of reactive oxygen species (ROS). CTSC could significantly activate p38 MAPK, resulting in the phosphorylation of the NADPH oxidase subunit p47phox, thereby facilitating the trafficking of cytoplasmic subunits to the cell membrane and activating NADPH oxidase. Moreover, CTSC up-regulated and activated its substrate membrane proteinase 3 (mPR3), resulting in an increased release of NETosis-related inflammatory factors. Inhibiting CTSC revealed great potential in mitigating NETosis-related injury during lung I/R. These findings suggests that CTSC from AMs may be a crucial factor in mediating NETosis during lung I/R, and targeting CTSC inhition may represent a novel intervention for PGD in LTx.
Abstract [solated cells are described that are not embryonic stem cells, not embryonic germ cells, and not genn cells. The cells can differentiate into at least one ce type of each of at least two of the endodermal, ectodermal, and mesodennal lineages. The cells 5 do not provoke a harmful immune response, The cells can modulate immune responses. As an. example, the celis can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjuncively, to treat subjects, For instance, the cells can be used adjunc tively for immunosnppression in transplant therapy. Methods for obtaining the 10 cells and compositions for using them also are described,
The Canadian Diabetes Association 2018 Clinical Practice Guidelines state that moderate to high levels of physical activity and cardiorespiratory fitness are associated with substantially lower morbidity and mortality in people with diabetes. The recommendations include a combination of aerobic, resistance, and flexibility exercises. The Guidelines specifically advocate for strategies that increase self-efficacy and motivation in order to increase physical activity uptake and maintenance.

Similarly, the importance of exercise counselling in primary care is widely recognized. Exercise is frequently identified as a key intervention for many chronic conditions, yet it remains under-prescribed. Physical activity counselling during routine diabetes care often takes a back seat to other issues, or lacks specific, actionable details that are important for patients to successfully integrate regular physical activity into their lifestyle. Moreover, even when prescribed, the successful implementation of physical activity behaviour changes remains a challenge for patients.

Eligible Rosemount Family Health Organization adult patients age \>=18 years with type 2 diabetes mellitus will receive an email or mail invitation to self-refer to a structured, facility-based, supervised aerobic and resistance exercise program. Interested patients will be invited to attend a 1-hour information session at the exercise facility at the time of implementation start up where they will complete an initial survey. Patients will then be free to attend up to 6 regularly-scheduled, group, free classes per week at a local exercise facility for a period of 3-months. Classes will be supervised by experienced trainers.

Measures of program success will focus around four themes, informed in part by the Institute for Healthcare Improvement's Triple Aim: (i) adherence to CDA guidelines for physical activity, (ii) patient experience, and (iii) health impact. Our balancing measure will be potential costs incurred by patients. Adherence measures, including percentage uptake (i.e. attend introductory session and one class), retention (at 1, 2 and 3-months), and percentage who meet CDA recommendations for exercise will be collected. Reasons for declined or discontinued participation will also be collected voluntarily from patients to help identify concrete or perceived barriers to structured exercise programs. Health-related measures will include quality of life (EQ-5D-5L) and exercise self-efficacy (Basic Psychological Needs in Exercise Scale, BP-NES). These will be measured by patient-report at 0, 1, 2, and 3-months. Participants will be asked to rate their "willingness to recommend" (Likert scale 1-10) the program to other individuals with T2DM. Additionally, pre- and post-exercise program hemoglobin A1c and blood pressure measurements (both of which are routinely collected for all patients with T2DM) will be obtained from patient charts. Finally, while this program will be free to patients, a hypothetical cost per patient will be estimated in order to gain an understanding of the financial costs compared to the value added through patient experience and health outcome measures.
Platelets are necessary for maintaining haemostasis. Separately, platelets are important for the propagation of inflammation during the host immune response against infection. The activation of platelets also causes inappropriate inflammation in various disease pathologies, often in the absence of changes to haemostasis. The separate functions of platelets during inflammation compared with haemostasis are therefore varied and this will be reflected in distinct pathways of activation. The activation of platelets by the nucleotide adenosine diphosphate (ADP) acting on P2Y1 and P2Y12 receptors is important for the development of platelet thrombi during haemostasis. However, P2Y1 stimulation of platelets is also important during the inflammatory response and paradoxically in scenarios where no changes to haemostasis and platelet aggregation occur. In these events, Rho-GTPase signalling, rather than the canonical phospholipase Cβ (PLCβ) signalling pathway, is necessary. We describe our current understanding of these differences, reflecting on recent advances in knowledge of P2Y1 structure, and the possibility of biased agonism occurring from activation via other endogenous nucleotides compared with ADP. Knowledge arising from these different pathways of P2Y1 stimulation of platelets during inflammation compared with haemostasis may help therapeutic control of platelet function during inflammation or infection, while preserving essential haemostasis. LINKED ARTICLES: This article is part of a themed issue on Platelet purinergic receptor and non-thrombotic disease. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.4/issuetoc.
NEW MATERIAL:The compound of formulaI(R<1> is halogen; R<2> is H or halogen; R<3> is methyl, ethyl, or hydroxyethyl). EXAMPLE:1-(4-Chlorophenylthio)-2-methylaminopropane fumarate. USE:Preventive and remedy for obesity and diabetes. It has low toxicity and is free from stimulating action to central vervous system. It can be administered safely for a long period. PROCESS:The compound of formulaIis prepared by reacting the thiophenol derivative of formula II with chloroacetone according to the reaction formula, and subjecting the resultant compound of formula III to the reductive amination reaction with R<3>NH2 using LiBH3CN or NaBH3CN as a reducing agent. The reaction is carried out in a solvent such as methanol, in the presence of 1-3mol of an acid such as HCl, using 2-20mol of R<3>NH2 based on 1mol of the compound of formula III.
Prodn. of a vaccine against leptospirosis is carried out by culturing a virulent strain of the serogroup icterohaemorrhagiae (serotype copenhageni and/or icterohaemorrhagiae) in a Reiter-Ramme medium contg. NaCl, phosphate buffer, rabbit serum and a small amt. of haeimmoglobin, at ca. 30 degrees C for 4-6 days. The harvested cultures are then inactivated and centrifuged at low temp. (>=10,000 G). The sediment is washed with formolated Sorensen buffer and recentrifuged to remove any remaining proteins. The product is pref. taken up in a physiological soln. to obtain a stock soln. from which doses of the vaccine can be made up. The vaccine is effective against the most prevalent (in France) pathogenic serotypes of the Leptospira spirochaete, and does not cause allergic reactions.
INTRODUCTION: Circulating tumor cells (CTCs) and Programmed death-ligand 1 (PD-L1) play pivotal roles in cancer biology and therapy response. This exploratory study aimed to elucidate the influence of neoadjuvant radiotherapy on PD-L1 expression in tumor tissues and CTCs of patients with inoperable locally advanced breast cancer.
METHODS: We conducted a prospective cohort study at Universitas Andalas Hospital Padang from January to December 2022 with 27 patients. Biopsies and blood draws were executed before and after the tenth fractions of neoadjuvant radiotherapy. Following radiotherapy, CTCs were isolated using magnetic beads enrichment, followed by an RT-PCR analysis for PD-L1 expression. Correlations between PD-L1 expression and tumor response, evaluated via local response and RECIST criteria before and after radiotherapy breast CT scan, were examined using Fisher's exact and chi-square tests.
RESULTS: Our data revealed no significant alterations in PD-L1 expression in either tumor tissues or CTCs during radiotherapy (p=0.848 for tissue, p=0.548 for CTCs). Notably, PD-L1 expression in tumor tissue before treatment was significantly associated with RECIST (p=0.021), while other correlations with local response and RECIST were not statistically significant.
CONCLUSION: The study implies radiotherapy may not significantly influence PD-L1 expression in tumor tissue and CTCs. However, pre-treatment PD-L1 expression in tumor tissue correlates with RECIST criteria. These findings highlight the need for additional, comprehensive studies to elucidate further the interplay between PD-L1, CTCs, and radiotherapy response.