anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Safety and effectiveness in pediatric patients below the age of 12 years have not been established. This product contains benzyl alcohol as a preservative. Benzyl alcohol, a component of this product, has been associated with serious adverse events and death, particularly in pediatric patients. The “gasping syndrome”, (characterized by central nervous system depression, metabolic acidosis, gasping respirations, and high levels of benzyl alcohol and its metabolites found in the blood and urine) has been associated with benzyl alcohol dosages >99 mg/kg/day in neonates and low-birth-weight neonates. Additional symptoms may include gradual neurological deterioration, seizures, intracranial hemorrhage, hematologic abnormalities, skin breakdown, hepatic and renal failure, hypotension, bradycardia, and cardiovascular collapse. Although normal therapeutic doses of this product deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. Premature and low-birth-weight infants, as well as patients receiving high dosages, may be more likely to develop toxicity. Practitioners administering this and other medications containing benzyl alcohol should consider the combined daily metabolic load of benzyl alcohol from all sources.

Premature neonates given doxapram have developed hypertension, irritability, jitteriness, hyperglycemia, glucosuria, abdominal distension, increased gastric residuals, vomiting, bloody stools, necrotizing enterocolitis, erratic limb movements, excessive crying, disturbed sleep, premature eruption of teeth, and QT prolongation that has resulted in heart block. In premature neonates with risk factors such as a previous seizure, perinatal asphyxia, or intracerebral hemorrhage, seizures have occurred. In many instances, doxapram was administered following administration of xanthine derivatives such as caffeine, aminophylline or theophylline.
Pain management can be one of the most challenging aspects of care for total joint arthroplasty patients. Poor post-operative pain control can lead to poor patient satisfaction and functional outcomes. Moreover, prolonged post-operative opioid utilization for post-operative pain is associated with substantial adverse sequelae. Identifying patients at high risk for poor post-operative pain control, and implementing strategies to improve pain management in this population is of utmost importance. One patient feature that has been shown to reliably predict poor post-operative pain management is pain catastrophizing. Currently available self-reported metrics such as the pain catastrophizing scale allow for pre-operative identification of patients who exhibit high levels of pain catastrophizing. Furthermore, there currently exist strategies which may effectively improve post-operative pain management in this population. One such strategy is "pre-emptive" analgesia utilizing ketamine administered at the time of surgery. Ketamine is commonly utilized in the treatment of both acute and chronic pain, and is believed to reduce pain intensity through a complex mechanism involving opioid receptors and excitatory neurotransmitters. It has been utilized in a variety of surgical procedures and has consistently been shown to reduce acute post-operative pain and analgesic consumption as long as 6 months after surgery, without a significant incidence of medication related side effects. To date, no study has evaluated the use of ketamine for total joint arthroplasty patients who demonstrate high levels of pain catastrophizing. We aim to study the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total hip and total knee arthroplasty who demonstrate high levels of pain catastrophizing.
The invention relates to a biomedical hemostasis material, in particular to a composite medical bio-fiber hemostasis modified material and a preparation method thereof. The material is prepared from collagen, lasiosphaera seu calvatia spore powder and hemostasis traditional Chinese medicine extract. Collagen can be rapidly combined with hemoglobin in blood to form hemostasis clots. A large amount of micro porous fiber is stored in lasiosphaera seu calvatia spore powder and can rapidly absorb moisture in blood so that blood vessel cracks and blood capillary blood oozing can be mechanically blocked. A physical barrier is formed by the two substances, isolates wounds and plays a role in adhesion prevention and immediate hemostasis. Extract of the hemostasis traditional Chinese medicine extract has the effects of hemostasis, inflammation resistance, bacterium resistance, analgesia, blood cooling, stasis eliminating, swelling reducing, convergence, coagulation system activation and wound healing promotion. The three substances are organically combined, and the material is remarkable in hemostasis effect, is used for wound surface blood oozing of various types of wounds and fresh tissue, small blood vessel bleeding and hemostasis in bleeding areas, can prevent adhesion and is particularly suitable for hemostasis in surgery.
During clinical development, the number of patients with myoclonic seizures exposed to levetiracetam was considerably smaller than the number with partial seizures. Therefore, underreporting of certain adverse events was more likely to occur in the myoclonic seizure population. In adult and adolescent patients experiencing myoclonic seizures, levetiracetam is associated with somnolence and behavioral abnormalities. It is expected that the events seen in partial seizure patients would occur in patients with JME.

In the double-blind, controlled trial in adults and adolescents with juvenile myoclonic epilepsy experiencing myoclonic seizures, 11.7% of levetiracetam-treated patients experienced somnolence compared to 1.7% of placebo patients. No patient discontinued treatment as a result of somnolence. In 1.7% of levetiracetam-treated patients and in 0% of placebo patients the dose was reduced as a result of somnolence.

Non-psychotic behavioral disorders (reported as aggression and irritability) occurred in 5% of the levetiracetam-treated patients compared to 0% of placebo patients. Non-psychotic mood disorders (reported as depressed mood, depression, and mood swings) occurred in 6.7% of levetiracetam-treated patients compared to 3.3% of placebo patients. A total of 5.0% of levetiracetam-treated patients had a reduction in dose or discontinued treatment due to behavioral or psychiatric events (reported as anxiety, depressed mood, depression, irritability, and nervousness), compared to 1.7% of placebo patients.
This is a multi-center, prospective, real-world observational study. Patients who have completed 6 months of induction therapy (YISAIPU 50mg / week ± csDMARDs) and achieved clinical remission or low disease activity will be observed for 2.5 years. During the maintenance period, through full communication between doctors and patients, YISAIPU 50 mg/wk or YISAIPU 25 mg/wk will be chosen as maintenance treatment. The clinical efficacy evaluation parameters include DAS28, HAQ-DI, modified Sharp score, continuous medication rate, and the recurrence rate of rheumatoid arthritis. Drug safety evaluation will include the incidence of adverse drug reactions and adverse drug events, the incidence of serious adverse events, and the incidence of adverse events leading to the reduction or withdrawal of YISAIPU due to adverse events. Exploratory observations wil include: (1) the incidence, clinical characteristics and disease changes of Interstitial Lung Disease, (2) the baseline abnormal rate and 3-year change of carotid intima-media thickness.
This is a first-in-human Phase 1 study to determine the safety, tolerability, and immunogenicity of UB-312 in healthy participants and in participants with Parkinson's disease (PD). UB-312 is a UBITh®-enhanced synthetic peptide-based vaccine and may provide an active immunotherapy option for treating synucleinopathies including the most prevalent form, PD.

The study consists of two parts. Part A of the study with healthy participants will consist of dose escalation and cohort staggering for up to seven planned dose levels or placebo. Part B of the study will consist of two cohorts of participants with Parkinson's disease (PD). Dosing for Part B will be based on safety, tolerability and immunogenicity from Part A. All eligible participants will be enrolled in a 44-week study consisting of 20 weeks of treatment and 24 weeks of follow-up.
Participants will observe actions with a standard reference. In this case, a basic digitally designed faceless doll will be used. A total of 16 different videos will be used, with 4 new videos each week. The videos will gradually increase in difficulty as the study progresses. All exercises are exercises used to improve balance.
BACKGROUND: In the Peruvian Amazon, Plasmodium vivax malaria transmission is maintained due to the high frequency of recurrences. By understanding the recurrence rates of submicroscopic and asymptomatic cases, we can develop informed strategies to prevent transmission more efficiently and disrupt the silent transmission cycle.
METHODS: A three-year, population-based cohort study was conducted in two sites, Cahuide and Lupuna, within the Loreto region in Peru from 2013 to 2015. The study included 385 individuals and aimed to examine the temporal dynamics of malaria recurrences and their impact on transmission and control.
RESULTS: Individuals from Lupuna presented a higher risk of P. vivax infections compared to Cahuide, where most recurrences were asymptomatic and submicroscopic. It is estimated that a great proportion of these recurrences were due to relapses in both communities. The application of molecular diagnostic method proved to be significantly more effective, detecting 2.3 times more episodes during the follow-up (PCR, 1068; microscopy, 467). PCR identified recurrences significantly earlier, at 151 days after an initial infection, compared to microscopy, which detected them on average after 365 days. Community, occupation and previous malaria infections were factors associated with recurrences. Finally, potential infection evolution scenarios were described where one frequent scenario involved the transition from symptomatic to asymptomatic infections with a mean evolution time of 240 days.
CONCLUSIONS: This study explores the contrast in malaria recurrence risk among individuals from two endemic settings, a consequence of prolonged exposure to the parasite. Through the analysis of the evolution scenarios of P. vivax recurrences, it is possible to have a more complete vision of how the transmission pattern changes over time and is conditioned by different factors.
A system and method for automating record keeping is disclosed. A client transmits patient information to a remote database via the Internet. The database stores the patient information and provides it to other clients as authorized. In some embodiments, the client inputs patient information in forms that have been pre-populated with known patient information or have only fields that need patient information. In other embodiments, a user completes modules for each patient. One set of modules may be used for all patients or the specific modules used for each patient may be customized. In further embodiments, the invention may be used in a behavioral healthcare services environment.
The invention discloses dendrobium instant powder and a preparation method thereof. The preparation method of the dendrobium instant powder comprises the following steps: preparing dendrobium candidum powder, preparing concentrated solution, preparing licorice extract and spray drying. The preparation method of the dendrobium candidum powder comprises the following steps: and (3) taking dendrobium candidum, drying, crushing and sieving to obtain dendrobium candidum powder. The preparation method comprises the following steps: adding Dendrobium officinale powder into ethanol solution, performing ultrasonic-assisted extraction, filtering, and concentrating to obtain Dendrobium nobile concentrated solution. The preparation method of the licorice extract comprises the following steps: decocting Glycyrrhrizae radix with water, and filtering to obtain Glycyrrhrizae radix extractive solution. The spray drying process comprises the following steps: mixing herba Dendrobii concentrated solution, the Glycyrrhrizae radix extract and beta-cyclodextrin, and spray drying to obtain powder which is the herba Dendrobii instant powder. The dendrobium instant powder prepared by the invention is easy to dissolve in water, rich and coordinated in aroma and good in taste.
In prior trials evaluating alternative methods of vaccine administration, scarification has been found to be an imprecise method of administration and allows only 1.0 - 2.5 microliters of immunogen to be given. Since it is not feasible to produce vaccine at concentrations higher than 10 to the 10th pfu/ml, this method limits the maximum deliverable dose. Intradermal and subcutaneous injection routes allow larger volumes of vaccinia to be given, i.e.: up to 200 microliters intradermally and up to 100 ml subcutaneously. In the present study, the initial priming dose will be the same administered by all 3 methods; however, the second priming dose administered at 2 months intradermally and subcutaneously will be 2 logs higher in order to achieve boosting of immune responses, particularly to gag and pol components of TBC-3B.

After volunteers are recruited, screened and enrolled in the study, they will be randomized to group C, D, or E. Each group will enroll 10 patients and 2 controls. The placebo control for TBC-3B will be standard vaccinia vaccination administered at doses no higher than that administered by scarification; the placebo control for MN rgp120 will be alum. Group C will receive undiluted TBC-3B by scarification, at months 0 and 2. Group D will receive diluted TBC-3B intradermally at month 0 and undiluted TBC-3B at month 2. Group E will receive diluted TBC-3B subcutaneously at month 0 and undiluted TBC-3B at month 2. At months 8 and 12 all groups will receive MN rgp 120/HIV-1 in alum intramuscularly.
There is synthesised a new heterocyclic compound 3-morfolinobenzanontrone ABM with phosphorous properties. The use of ABM as phosphorous probe has allowed the creation of a new method for qualitative evaluation of cell membrane structures and organism immunity. The invention offers a new approach to the solution to the recording of AMB spectral parameters in suspension of immunocompetent lymphatic cells. Correlation has been established in ABM spectral characteristics of donor and patient cells suspensions, the indices of blast transformation reaction, anisotropy index, as well as contents of subpopulations and their relations in the peripheral lymphatic cells. It has been discovered that intensity of ABM fluorescence characterises state of immune system, allows evaluating changes in specific parameters of immune system as well as describe relations between these parameters. It must be pointed out that changes of parameters are directly related to development of disease. The method reduces time requirements, amplifies the amount of acquired information. Besides, there is no need to use expensive chemicals and equipment.
In Group B (retrograde intrarenal surgery cases), a 0.035 Fr guidewire will be inserted into the ureteric orifice under fluoroscopic guidance. Ureteric dilatation will be done with serial semi-rigid dilators 6- 16 Fr (Nidhi Meditech) followed by 14-16 Fr access sheath. Stone disintegration will be done with the LithoVue Flexible URS (Boston Scientific, Massachusetts, U.S.) which has a shaft length of 68 cm, distal tip diameter is 7.7-10 F, working channel inner diameter is 3.6 F, and the angle of deflection of distal tip is 270 degrees.
Most suicide attempts are a sign of great distress, often originating from depression; physical and sexual abuse; substance abuse; or family history of suicide, violence, or mental disorder. Risk factors for suicidal behavior are diverse, differing with gender, age, and ethnicity. Since the mid-1980s, the number of reported suicides and suicidal thoughts among young black individuals has increased alarmingly. The higher rates may be caused by high stress living situations attributed to poverty, abuse, discrimination, racism, and difficult family life. Therefore, cultural environments, social situations, and intrapersonal influences are important considerations in developing an effective therapy to prevent suicide. This study will evaluate the effect of culturally competent psychoeducational empowerment sessions in treating suicidal African-American women who are in abusive relationships.

The participants in this single-blind study will be randomly placed in one of two treatment groups. One group will receive psychoeducational intervention (PEI) and the other will receive enhanced treatment as usual (ETAU). After screening, eligible participants will complete a 2-hour survey about life events, concerns, and feelings with a research team member. One week later, participants will complete a second 1-hour survey. Participants will then be randomly placed in the treatment groups. Participants in both groups will receive treatment at Grady Health System, but those in the PEI group will also attend 10 weekly, 90-minute group sessions. The PEI empowerment group sessions will incorporate cultural, social, and intrapersonal elements. The ETAU group will be given mental health treatment as usual plus an adherence enhancement protocol. Follow-up surveys will occur at Week 10 (after treatment completion) and at Months 6 and 12 post-treatment.
The invention discloses a tissue pathology image classification method based on image Bert, and relates to a problem of classification of normal and abnormal tissue sections in tissue pathology detection. The tissue pathology images are classified through the deep neural network, so that the workload of a pathologist can be effectively reduced, and the accuracy and efficiency of diagnosis are improved. The abnormal tissue classification depends on the local and global characteristics of tissue slices, and the traditional image classification network is limited by the size and the computing capacity of a model, can only process smaller images and is difficult to classify by combining the global characteristics. Meanwhile, when the classification model is trained, a large amount of labeled data is needed, and data acquisition is difficult. Aiming at the problems, a histopathology image classification method based on image Bert is provided. Test results show that the method can effectively utilize the label-free information for training, and combines the global characteristics to code the small images, thereby effectively improving the classification effect. The method is mainly applied to tissue pathology image classification.
OBJECTIVE: To estimate the catastrophic health expenditure and distress financing of breast cancer treatment in India.
METHODS: The unit data from a longitudinal survey that followed 500 breast cancer patients treated at Tata Memorial Centre (TMC), Mumbai from June 2019 to March 2022 were used. The catastrophic health expenditure (CHE) was estimated using households' capacity to pay and distress financing as selling assets or borrowing loans to meet cost of treatment. Bivariate and logistic regression models were used for analysis.
FINDINGS: The CHE of breast cancer was estimated at 84.2% (95% CI: 80.8,87.9%) and distress financing at 72.4% (95% CI: 67.8,76.6%). Higher prevalence of CHE and distress financing was found among rural, poor, agriculture dependent households and among patients from outside of Maharashtra. About 75% of breast cancer patients had some form of reimbursement but it reduced the incidence of catastrophic health expenditure by only 14%. Nearly 80% of the patients utilised multiple financing sources to meet the cost of treatment. The significant predictors of distress financing were catastrophic health expenditure, type of patient, educational attainment, main income source, health insurance, and state of residence.
CONCLUSION: In India, the CHE and distress financing of breast cancer treatment is very high. Most of the patients who had CHE were more likely to incur distress financing. Inclusion of direct non-medical cost such as accommodation, food and travel of patients and accompanying person in the ambit of reimbursement of breast cancer treatment can reduce the CHE. We suggest that city specific cancer care centre need to be strengthened under the aegis of PM-JAY to cater quality cancer care in their own states of residence.
TRIAL REGISTRATION: CTRI/2019/07/020142 on 10/07/2019.
NEW MATERIAL:A compound shown by the formula I [A is amino, acylamino, guanidino, etc.; n is integer of 1-3; B is group shown by the formula II (Y is phenyl, or substituted phenyl), group shown by the formula III, or group shown by the formula IV (Z is carboxy lower alkyl)] or its acid addition salt. EXAMPLE:2-Amino-4-(4-hydroxy, 4-phenylpiperidin-1-ylmethyl)-thiazole. USE:Having antihistaminic action, especially having extremely inhibitory action on secretion of gastric juice, useful as a drug. PROCESS:A compound shown by the formula V (X is halogen) is reacted with a compound shown by the formula H-B in the presence of a base such as sodium methoxide, etc. in a solvent such as THF, etc. at room temperature or under heating, to give a compound shown by the formula I .
In this combination therapy group, the participants will received 2 weeks of RT using the ArmeoSpring and followed by 2 weeks of distributed CIT. The treatment principles of RT and distributed CIT are the same with those described in the monotherapy of RT or dCIT, respectively. This combined intervention group may integrate proximal (shoulder and elbow) to distal (wrist and hand) training of the UL and help transfer from motor ability gained to functional performance improvement. That is, it appears to associate with the advantages/effects of each RT and dCIT intervention.
The present invention discloses a Chinese medicinal preparation for treating condyloma acuminatum. Traditional Chinese medicines, comprising realgar, java brucea fruit, raw natril sulfas and borneol, are adopted as raw materials and are prepared into paste or water liniment proportionally according to different characteristics of each traditional Chinese medicine. The Chinese medicinal preparation has the effects for resisting inflammation, disinfecting toxin, sterilizing bacteria, relieving itch, eliminating dampness, cooling blood, clearing heat to stop bleeding, purging fire for removing toxin, promoting flow of qi and blood circulation, alleviating pain, removing dampness by diuresis, moistening dryness, inducing diuresis to alleviate edema, removing stasis and stopping pain. The medicine directly acts on a focus, and has concentrated and lasting potency. Through clinical verification, the Chinese medicinal preparation has an obvious curative effect, and the cure rate of one course of treatment reaches 96.2%. The Chinese medicinal preparation has the advantages of convenience and comfortability for use, no cause of pain or wound, no toxic or side effect, unique formula and preparation method, low cost, convenient transportation, portability and easy storage. The Chinese medicinal preparation is suitable for various types of condyloma acuminatum.