anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The rich nutrients contained in breast milk ensure the survival and healthy growth of the newborn . Apart from being a nutrient for the mother and the newborn, breast milk and breastfeeding have many benefits in terms of psychological, social development, immune system, developmental, spiritual, social and financial benefits . It is recommended that the baby should not be breastfed without additional food for the first 6 months . However, although the rate of breastfeeding in Turkey is 98%, the rate of babies being fed only breast milk for the first 6 months is reported to be 41% in the Turkey Population and Health Survey (TDHS)-2018 report. It is very important that breastfeeding begins and continues successfully. However, the breastfeeding process can be affected by many factors related to mother and baby. The mother may not be able to cope alone with some challenging factors such as breast rejection, frequent crying, dissatisfaction after breastfeeding, small amounts of defecation, and insufficient breast milk. In case of possible or real problems with breastfeeding, breastfeeding counseling is required . Providing breastfeeding education and counseling is one of the most important roles and responsibilities of midwives during pregnancy, birth and postpartum . The breastfeeding support that the mother receives from midwives greatly affects breastfeeding decisions. Effective breastfeeding support increases breastfeeding duration and success . Midwifery students are given training on breast milk and breastfeeding in accordance with the Midwifery National Core Education Program (EUÇEP). The purpose of breastfeeding counseling training is to train people to evaluate and manage breastfeeding problems . During the breastfeeding consultancy process; The aim is to support mothers in breastfeeding, to reveal the causes of breast milk insufficiency and to implement practices to increase breast milk However, it has been emphasized in the literature that midwives' breastfeeding counseling is not at the desired level . Breastfeeding counseling course is not included in the curriculum of midwifery departments of every university in Turkey . Studies have also shown that mothers are not always satisfied with the breastfeeding support they receive from midwives after birth A quality education based on evidence-based breastfeeding counseling is required for midwives and midwifery students to provide effective breastfeeding support to breastfeeding women tfeeding is effective in successfully maintaining the self-efficacy and breastfeeding behavior of mothers during the lactation process . It is thought that with this research, the curriculum of the midwifery department of the breastfeeding counseling course will be reviewed and will contribute positively to the increase in breastfeeding rates in our country in the future. The purpose of this research is to determine the effect of breastfeeding counseling training on midwifery students' perception of breast milk and infant feeding attitudes.
All participants will be identified via the geriatrician of the mobile geriatric team with the following inclusion criteria: age ≥ 75 years, ≥ 5 medications per day and being hospitalised either in emergency room, short-stay medicine unit or in a surgery department. For each patient, the pharmacist will detect potentially inappropriate prescribing (based on explicit criteria and an implicit approach) and liaise with the geriatrician for drug optimisations. The pharmaceutical advice will be added to the geriatrician's written report, and then addressed to the relevant physician. The implementation of the proposals will be evaluated immediately at the end of hospitalisation, and then reassessed three months later by calling the patient and/or his community pharmacist. A total of 250 patients will be enrolled over a 12 month-period. The evolution of potentially inappropriate prescribing will be assessed and their cost evaluated.
This study aimed to investigate the association between non-traditional lipid profiles and the risk of 1-year vascular events in patients who were already using statins before stroke and had admission LDL-C < 100 mg/dL. This study was an analysis of a prospective, multicenter, nationwide registry of consecutive patients with acute ischemic stroke patients who treated with statin before index stroke and LDL-C < 100 mg/dL on admission. Non-traditional lipid profiles including non-HDL, TC/HDL ratio, LDL/HDL ratio, and TG/HDL ratio were analyzed as a continuous or categorical variable. The primary vascular outcome within one year was a composite of recurrent stroke (either hemorrhagic or ischemic), myocardial infarction (MI) and all-cause mortality. Hazard ratios (95% Cis) for 1-year vascular outcomes were analyzed using the Cox PH model for each non-traditional lipid profiles groups. A total of 7028 patients (age 70.3 ± 10.8years, male 59.8%) were finally analyzed for the study. In unadjusted analysis, no significant associations were observed in the quartiles of LDL/HDL ratio and 1-year primary outcome. However, after adjustment of relevant variables, compared with Q1 of the LDL/HDL ratio, Q4 was significantly associated with increasing the risk of 1-year primary outcome (HR 1.48 [1.19-1.83]). For the LDL/HDL ratio, a linear relationship was observed (P for linearity < 0.001). Higher quartiles of the LDL/HDL ratio were significantly and linearly associated with increasing the risk of 1-year primary vascular outcomes. These findings suggest that even during statin therapy with LDL-C < 100 mg/dl on admission, there should be consideration for residual risk based on the LDL/HDL ratio, following stroke.
The intervention arm (target enrollment; n=180) will receive personalized dietary guidelines created by machine learning algorithms using their personal anthropometric, gut, dietary and medical information as inputs. The guidelines will be delivered in the form of a smartphone/ smart device app.
Resistance training will consist of a supervised circuit training 3 sessions/week for approximately 45-50 min/session. The circuit will include 7 strength exercises engaging the major muscle groups (leg press, rows, back squats, weighted crunches, deadlifts, bench press, and squat jumps with weights). The participants will perform 3 sets of 10 repetitions with resting periods of 30 seconds between exercises, and 2 minutes between sets. The overall OMNI-Resistance Exercise Scale per set will range between 8-10. Heart rate and exercise energy expenditure during the workout will be monitored. The load will be changed depending on the participants' perception when needed. In addition, the intensity will be monitored assessing Lactate concentrations at baseline and at the end of each session. Circuit will be repeated until meeting the targeted exercise energy expenditure of 450-500 kcal/session.
Carcinogenesis

Rats were dosed with levetiracetam in the diet for 104 weeks at doses of 50, 300 and 1800 mg/kg/day. The highest dose is 6 times the maximum recommended daily human dose (MRHD) of 3000 mg on a mg/m basis and it also provided systemic exposure (AUC) approximately 6 times that achieved in humans receiving the MRHD. There was no evidence of carcinogenicity. In mice, oral administration of levetiracetam for 80 weeks (doses up to 960 mg/kg/day) or 2 years (doses up to 4000 mg/kg/day, lowered to 3000 mg/kg/day after 45 weeks due to intolerability) was not associated with an increase in tumors. The highest dose tested in mice for 2 years (3000 mg/kg/day) is approximately 5 times the MRHD on a mg/m basis. 22

Mutagenesis

Levetiracetam was not mutagenic in the Ames test or in mammalian cells in the Chinese hamster ovary/HGPRT locus assay. It was not clastogenic in an analysis of metaphase chromosomes obtained from Chinese hamster ovary cells or in an mouse micronucleus assay. The hydrolysis product and major human metabolite of levetiracetam (ucb L057) was not mutagenic in the Ames test or the mouse lymphoma assay. in vitroin vitroin vivoin vitro

Impairment of Fertility

No adverse effects on male or female fertility or reproductive performance were observed in rats at oral doses up to 1800 mg/kg/day (6 times the maximum recommended human dose on a mg/m or systemic exposure [AUC] basis). 2
INTRODUCTION: Untreated hearing loss is reported to negatively impact on an individual's quality of life, affecting their psychological and physical health and placing them at greater risk of developing dementia. Despite this, hearing loss management is often delayed by up to a decade. This is likely due to difficulties in navigating the hearing care pathway, and the absence of a central, unbiased reference point for consumer-friendly hearing health information and resources. We intend to co-design an online support service for adults with hearing loss with the following aims: 1) to understand unmet needs and consumer barriers to accessing hearing health information, 2) to identify solutions to these unmet needs that can be developed into prototype ideas, 3) to incrementally build on iterations of a prototype until a usable online support service is developed and ready for real-life testing with end-users, and 4) to test and evaluate the usability, accessibility, and effectiveness of the prototype from the consumer's perspective, so that the prototype can be refined into the final product.
METHODS AND ANALYSIS: This will be a mixed method study. Consumers will be involved in all stages of the design of the project following the Hasso Plattner model of design thinking. The qualitative component will involve sprints and semi-structured interviews to access the consumer perspective and understand unmet needs and challenges regarding the access of online hearing health information. For the quantitative component, an online survey will be administered prior to prototype testing as part of the remote usability study to collect self-efficacy and eHealth literacy outcome measures via validated questionnaires. Data collection will also be performed post-prototype testing for evaluation purposes. Finally, heuristic evaluation of the prototype will be conducted by an eLearning expert to help refine the prototype into the final product.
BACKGROUND: The quest for dependable biomarkers to predict responses to immune checkpoint inhibitors (ICIs) combined with chemotherapy in advanced non-small cell lung cancer remains unfulfilled. HOXC9, known for its role in oncogenesis and creating a suppressive tumor microenvironment (TME), shows promise in enhancing predictive precision when included as a TME biomarker. This study explores the predictive significance of HOXC9 for ICI plus chemotherapy efficacy in lung adenocarcinoma (LUAD).
METHODS: Following the bioinformatic findings, assays were performed to ascertain the effects of Hoxc9 on oncogenesis and response to programmed death 1 (PD-1) blockade. Furthermore, a cohort of LUAD patients were prospectively enrolled to receive anti-PD-1 plus chemotherapy. Based on the expression levels, baseline characteristics, and clinical outcomes, the predictive potential of HOXC9, PD-L1, CD4, CD8, CD68, and FOXP3 was integrally analyzed. HOXC9 not only mediated oncogenesis, but also corelated with suppressive TME. CMT167 and LLC cell lines unveiled the impacts of Hoxc9 on proliferation, invasion, and migration. Subsequently, tumor-bearing murine models were established to validate the inverse relationship between Hoxc9 expression and effective CD8+ T cells.
RESULTS: Inhibition of Hoxc9 significantly curtailed tumor growth (P<0.05), independent of PD-1 blockade. In patient studies, while individual markers fell short in prognosticating survival, a notable elevation in CD8-positive expression was observed in responders (P=0.042). Yet, the amalgamation of HOXC9 with other markers provided a more distinct differentiation between responders and non-responders. Notably, patients displaying PD-L1+/HOXC9- and CD8+/HOXC9- phenotypes exhibited significantly prolonged progression-free survival.
CONCLUSIONS: The expression of HOXC9 may serve as a biomarker to amplifying predictive efficacy for ICIs plus chemotherapy, which is also a viable oncogene and therapeutic target for immunotherapy in LUAD.
Randomized trial to investigate the impact of different stent designs on the target lesion restenosis rate in femoro-popliteal arteries. Immediately after stent implantation, sets of three orthogonal angiographic views (separated by an angle of \> 25°) of the stented region (TL) will be obtained with the leg in supine position. This will be followed by intra-arterial imaging using Optical Coherence Tomography (OCT). OCT images (one pullback if the lesion length is \< 75 mm, 2 pullbacks otherwise) of the TL will be acquired using the Dragonfly catheter. In addition, duplex ultrasound (DU) of the TL will be performed, including the arterial segments 10cm at proximal and distal edge of the TL. Thereafter, a bending cast will be used to obtain a knee/hip flexion of approximately 70°/20°. In this position the angiographic, OCT, and DU measurements will be repeated.

The OCT images will provide the shapes of the arterial lumen which will be used to generate 3D surface models (in .stl format). The X-ray images will be utilized to construct the 3D arterial centerline for the supine and flexed leg positions. These arterial centerlines will be used to quantify the axial deformation (in mm), twisting (in °), and curvature changes (in mm-1) along the length of the investigated segment. Additionally, the lumen profiles obtained from OCT images will be used to accurately estimate the radial deformations (in mm) in the lumen and define instances of arterial pinching during leg flexion (as the difference in lumen diameters between straight and flexed leg positions).

The geometries of the arterial lumens will be combined with their corresponding 3D arterial centerlines to generate patient-specific arterial models. Along with patient-specific boundary conditions obtained from DU measurements, these models will be transferred to a commercial software, to perform Computational Fluid Dynamics analyses. The changes in these parameters due to leg flexion, as well as due to different stent designs, will be quantified.
The stress factors that nursing students encounter differ from other students. One of the reasons for this is that the nursing curriculum includes working simultaneously in both theoretical and clinical environments. In a study, it was determined that nursing students' lack of stress coping skills caused internal stressors to turn into external stressors. When these individuals cannot cope with situations that cause stress, they can express the stress they experience with somatic symptoms. Somatic symptom disorder is defined as the state of seeking help for mental problems with somatic symptoms. The inability to treat these somatic symptoms of individuals forces them to live with these symptoms for years and sometimes for a lifetime and continue to seek treatment. Acceptance and Commitment Therapy, which provides a new perspective for individuals to cope with stressful life events, aims to gain psychological flexibility, which is the capacity for individuals to experience challenging conditions at the moment they are in and to behave in a way that is compatible with their value areas under these conditions. The opposite of psychological flexibility is psychological inflexibility. Experiential avoidance is one of the basic components of the concept of psychological inflexibility. The state of escape and avoidance and actions that occur when an individual does not want to be in contact with situations that stress them are defined as experiential avoidance. When the relevant literature is examined, it has been reported that somatic symptoms are seen as experiential avoidance behaviors in individuals. The continuity of somatic symptoms as a reaction to stress, their inability to intervene, and their chronicity cause them to turn into a somatic somatic symptom disorder. Since nursing students are a highly stressed group, their reactions to stress should be observed, somatic symptoms in these students should be evaluated, and psychological flexibility should be increased before somatic symptoms turn into disorders and students start their professions, and healthier members of the profession should be trained in terms of mental and physical health. However, psychosocial intervention studies that will help with somatic symptoms continue to be the subject of very little research.
Randomized at daily time point to receive a maternal-focused message. Randomization probability for this arm is .40.
Using CO2, diode or similar wavelenght laser the stenotic tracheal segment will be vaporized allowing a less than 20% residual stenosis. Dilatation will not be performed after laser resection for residual stenosis.
This invention is related to in situ gel formation for ophthalmic delivery by combining Pluronic/Carbopol medic composition and its preparing method. A series of polymer solutions with different compositions were prepared in this invention, including Pluronic, Carbopol solution and Pluronic/Carbopol mixture. After discussing their rheological behavior and in vivo, in vitro drug release profile, the best in situ gel formation formulation for drug delivery system could be figured out. Carbopol is the polymer composed of polyacrylic acid (PAA) which will transform from sol to thick gel when pH value is higher than the pKa value of the solution (about 5.5). Pluronic is the copolymer composed of polyoxyethylene and polyoxypropylene in which gel formation will be produced with rising temperature. This invention discovers that: the most suitable concentration of Pluronic solution to be used as in situ gel formation ophthalmic delivery system is 14% (w/w). And that for Carbopol solution is 0.3% and 0.4% (w/w). Using Carbopol as viscosity intensifier could provide gel intensity of the combination formulation (14% Pluronic/0.3% Carbopol) under physiological condition. This combination formulation could flow freely at pH 4.0 and 25 DEG C. And its rheological behavior is also very stable after adding the drug substance (Pilocarpine). Results of in vivo and in vitro studies demonstrate that: this combination formulation is better than single solution formulation on the aspect of prolonging drug retention time on eye cornea. Therefore this combination formulation is suitable for ophthalmic drug delivery system and increases bioavailability of the drug.
Families with children in this study arm will not receive any herring during the 8-10 week period when Immediate Herring families receive a weekly ration of herring. After the 8-10 week (end line) measurements, an equal amount of herring will be distributed to the family.
OBJECTIVE: There were two objectives of this current study. (1) To understand the impacts of hearing loss for late-deafened adults and the experiences of support received both from hearing healthcare providers and peers. (2) To understand the types of support needed during and after a cochlear implant.
DESIGN: The study used mixed methods. A survey was posted to three cochlear implant social media groups and participants could self-select to participate in a semi-structured interview by leaving their email address.Study sample: Forty-four late-deafened adults who had also received at least one cochlear implant answered the survey and 16 people were interviewed.
RESULTS: A key finding was that most late-deafened adults did not have access to support through the progression of deafness. They often felt alone, making it difficult to maintain their sense of self while reconciling with the hearing changes forced on them. When participants had positive role models who had experienced hearing loss, or mentors who had undergone cochlear implantation, it assisted them in navigating their changing hearing status. Thus, improved connection to peers sustained self-esteem and improved coping strategies.
CONCLUSIONS: The findings suggest hearing healthcare providers need to introduce a mentoring and support structure for connected care.
BACKGROUND: The consequences of chronic kidney disease (CKD) can be addressed with a range of pharmacotherapies primarily prescribed by nephrologists. More accurate information regarding future CKD-related pharmacotherapy requirements could guide clinical decisions including follow-up frequency.
METHODS: Following assignment to derivation and validation groups (2,1), variables predicting individually future use of vitamin D receptor agonists (VDRA), phosphate binders, erythropoiesis stimulating agents (ESAs) and iron were identified using logistic regression in a prospective cohort study containing demography, comorbidity, hospitalization, laboratory, and mortality data in patients with CKD stage G4/G5 across six European countries. Discriminative ability was measured using C-statistics, and predicted probability of medication use used to inform follow-up frequency.
RESULTS: A total of 2196 patients were included in the analysis. During a median follow-up of 735 days 648 initiated hemodialysis and 1548 did not. Combinations of age, diabetes status and iPTH, calcium, hemoglobin and serum albumin levels predicted the use of ESA, iron, phosphate binder or VDRA, with C-statistics of 0.70, 0.64, 0.73 and 0.63 in derivation cohorts respectively. Model performance in validation cohorts were similar. Sixteen percent of patients were predicted to have a likelihood of receiving any of these medications of less than 20%.
CONCLUSIONS: In a multi-country CKD cohort, prediction of ESA and phosphate binder use over a two-year period can be made based on patient characteristics with the potential to reduce frequency of follow-up in individuals with low risk for requiring these medications.
Crystallized aescin or primulic acid are subjected to shearing forces in a grinding apparatus for a time sufficient to destroy the crystal structure and to convert the saponin to an X-ray amorphous state of increased water solubility. The saponins are ground in an agate or hard porcelain mortar.  The required shearing forces are not normally obtained in a ball or jet mill, but necessitate grinding in a mortar or mortarmill, or in a roll mill in which the rolls are rotated at different speeds.  The crystallized aescin or primulic acid may be mixed with a flavonoid glucoside such as hesperidin and then subjected to the above shearing forces to form a complex with the aescin or primulic acid.ALSO:A therapeutically valuable saponin preparation containing aescin or primulic acid having an X-ray amorphous state of increased water solubility is prepared by subjecting crystallised aescin or primulic acid to shearing forces for a time sufficient to destroy the crystal structure.  The crystallised aescin or primulic acid may also be mixed with a flavonoid glucoside such as hesperidin and then subjected to the above shearing forces, when a complex with the aescin or primulic acid is also formed.  The saponin preparations are suitable for oral application, e.g. as tablets or dragees.  For oral administration with resorption in the digestive tract, a preparation of x-ray amorphous aescin or of an aescin-hesperidin complex containing 1-30 parts by weight of hesperidin per 100 parts by weight of aescin may be used.