anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention leads sulphuric acid galactosan and a derivative thereof to be used for preparing antiviral agents, antitumour agents, antioxidants, immunomodulators and bacteriostatic agents. Experiments prove that the sulphuric acid galactosan has strong biological activity. Because the biological activity of the sulphuric acid galactosan have a close relation to the molecular weight, the structure, the content of sulphur and an existence position, a possible reason is that the spatial structure of polysaccharide has the important function for the biological activity, and the recognition reaction of many receptors is on the basis of the spatial structure. The sulphuric acid galactosan which has high polymerization degree is not easily absorbed by organisms, the sulphuric acid galactosan can not enter a purpose tissue, and a segment which has too low polymerization degree does not easily form an effective spatial structure which can cause the recognition reaction of the organism. The present invention obtains oligosaccharide which has the proper polymerization degree and obtains a derivative through specific chemical modification. The oligosaccharide and the derivative can be rapidly absorbed by the organism, and therefore, the oligosaccharide and the derivative can enter a purpose tissue to exert functions. In addition, the safety is high.
ATP depletion plays a central role in the pathogenesis of kidney diseases. Recently, we reported spatiotemporal intracellular ATP dynamics during ischemia reperfusion (IR) using GO-ATeam2 mice systemically expressing an ATP biosensor. However, observation from the kidney surface did not allow visualization of deeper nephrons or accurate evaluation of ATP synthesis pathways. Here, we established a novel ATP imaging system using slice culture of GO-ATeam2 mouse kidneys, evaluated the ATP synthesis pathway, and analyzed intracellular ATP dynamics using an ex vivo IR-mimicking model and a cisplatin nephropathy model. Proximal tubules (PTs) were found to be strongly dependent on oxidative phosphorylation (OXPHOS) using the inhibitor oligomycin A, whereas podocytes relied on both OXPHOS and glycolysis using phloretin an active transport inhibitor of glucose. We also confirmed that an ex vivo IR-mimicking model could recapitulate ATP dynamics in vivo; ATP recovery in PTs after reoxygenation varied depending on anoxic time length, whereas ATP in distal tubules (DTs) recovered well even after long-term anoxia. After cisplatin administration, ATP levels in PTs decreased first, followed by a decrease in DTs. An organic cation transporter 2 inhibitor, cimetidine, suppressed cisplatin uptake in kidney slices, leading to better ATP recovery in PTs, but not in DTs. Finally, we confirmed that a mitochondria protection reagent (Mitochonic Acid 5) delayed the cisplatin-induced ATP decrease in PTs. Thus, our novel system may provide new insights into the energy dynamics and pathogenesis of kidney disease.
The invention discloses a foot bath liquid for relaxing tendons and activating collaterals, and a production method thereof. The foot bath liquid is prepared from the following raw materials in parts by weight: 15-30 parts of ginger, 3-6 parts of folia perillae acutae, 10-20 parts of radix cudramiae, 10-20 parts of parabarium micranthum pierre, 1-3 parts of cassia twig and 200 parts of white spirit. The preparation method comprises the following steps: crushing the radix cudramiae, the parabarium micranthum pierre and the cassia twig to be below 50 meshes; adding 3-5fold clean water to boil for 20-30 minutes according to the total weight of the raw materials; mashing the ginger and the folia perillae acutae, and then merging; adding 200 parts of alcohol or white spirit of 40-60 degrees, soaking for over 30 days by a sealed container, so as to obtain the foot bath liquid product. By using the method, hot water of 60-80 DEG C is contained in a vat; 0.2-0.3kg of filtered foot bath liquid is poured into 10kg of hot water; the water is cooled to a proper temperature, so as to soak the feet. The foot bath liquid product disclosed by the invention does not need to be decocted by a traditional Chinese medicine pot. Thus, time and labor are saved, and the foot bath liquid is convenient to use.
Primary biliary cirrhosis (PBC) is often associated with abnormalities in serum lipids. Hypercholesterolemia is an established risk factor for cardiovascular morbidity and mortality. Since many PBC patients have a very slow progression of their underlying liver disease cardiovascular risk factors may become more relevant as prognostic facors. Whether statins lower serum cholesterol levels and reduce the cardiovascular risk in PBC patients remains to be determined. Statins are generally well tolerated and are not associated with an increased risk of hepatotoxicity in patients with nonalcoholic fatty liver disease (NAFLD). However only limited data on safety on statins in chronic cholestatic liver diseases are available. In a recent pilot study at the Medical University of Graz atorvastatin did not statistically increase liver enzymes in PBC patients. However, data on long-term treatment with atorvastatin in these patients are not yet available. Moreover, long-term treatment with statins may have potential beneficial immunomodulatory effects on the disease course of PBC in analogy to other immune-mediated disorders such as rheumatoid arthritis and multiple sclerosis.
Mental illness poses a challenge to public mental health services because of its high prevalence, symptom chronicity, and impacts on patients and society. Although there is a huge amount of need to serve people with mental illness, there is insufficient manpower. There is much empirical evidence to support the volunteer programs for people with mental illness. However, the literature on hybrid volunteer training is mainly focused on teaching and learning in education, and the effectiveness of the hybrid volunteer training in Hong Kong is under-studied. Therefore, The present study aims to compare the efficacy of hybrid volunteer training with the wait-list control group. We hypothesize that (1) participants who receive hybrid volunteer training will increase their self-efficacy of volunteering after the intervention as compared with the wait-list controls; (2) participants from hybrid volunteer training will have better mental health knowledge and less mental health-related stigmatized beliefs and behavior after the intervention as compared with the wait-list controls.

The volunteer training will consist of a 6-module online course, followed by 5 face-to-face courses, incorporating the key volunteer training components, including Keyes theory, bio-psycho-social model, stress bucket model, recovery model and CHIME model. Each module will consist of the key volunteer training component presented in in written or video format. Materials will be presented interactively to facilitate engagement.
Patients in the non-comparative historical reference cohort (with less sensitization and negative XM) randomly selected from the CTS registry have been transplanted and treated in accordance with standard-of-care for kidney transplanted patients. Patients transplanted in 2010 and onwards will be selected to optimize the probability that these patients will have received about the same maintenance immunosuppressive treatment as the patients in the current trial will receive.
Participants received DTG 50 mg + RPV 25 mg together, once daily, at approximately the same time, with a meal, in an open-label fashion up to Week 52, during the Early Switch Phase. Participants continued to receive DTG 50 mg + RPV 25 mg up to Week 148 during the Late Switch Phase. Participants who successfully completed 148 weeks of treatment were given the opportunity to continue to receive DTG + RPV once daily in the Continuation Phase (after Week 148).
The invention relates to a method, a signal processing unit and a ventilator, which automatically set a target value for the frequency with which the ventilator performs a breathing stroke and thereby artificially breathes a patient. The alveolar or proximal minute volume is pre-defined. A lung time constant of a patient's lung is determined. The volume of dead space in the fluid connection between the lung and the treatment device is determined. The forced nominal frequency of forced breathing of the patient is calculated (f  set,mand ). The ideal frequency (f  spon ) at which the patient can reach the minute volume by spontaneous breathing is calculated. The nominal respiratory rate is calculated as a weighted average of the forced nominal frequency (f  set,mand ) and the ideal frequency (f  spon ). The average depends on the determined actual intensity of spontaneous breathing of the patient.
PROBLEM TO BE SOLVED: To prevent the wastage of a domestic animal by reinforcing immune activity, preventing infections disease such as a cold and also protecting stress by feeding an oil and fat-coated vitamin C to the domestic animal. SOLUTION: This method for protecting the wastage of a domestic animal is provided by feeding (A) 5-50 (g/day head) oil and-fat-coated vitamin C, and preferably (B) 1-20 (g/day head) chromium yeast and (C) 10-500 (g/day head) theriac for reinforcing immune activity, preventing infectious disease such as a cold, protecting stress and improving the amount of eating of a feed. The oil and fat of the component A is a hardened oil and fat and especially a hardened soybean oil and fat is preferable. The heardened oil and fat preferably has <=5 acid value, <=3 iodine value and 60-65 deg.C melting point. The component B is a beer yeast and contains 1,000-1,600 ppm non-toxic trivalent chromium. Also it is preferable to use 10-100 pt.wt. coating oil and fat based on 100 pts.wt. vitamin C.
Though echinocandins are the first line of therapy for C. auris candidemia, there is little clinical data to guide the choice of therapy within this class. This was the first study to compare the three echinocandins in terms of efficacy and outcomes for C. auris candidemia. This was a retrospective analysis of 82 episodes of candidemia caused by C. auris comparing outcomes across the three echinocandins. Majority patients in our study were treated with micafungin. Susceptibility rates were the lowest for caspofungin (35.36% resistance), with no resistance reported for the other two echinocandins. When a susceptible echinocandin was chosen, caspofungin resistance was not a factor significantly associated with mortality. Also, when a susceptible echinocandin was used for therapy, the choice within the class did not affect clinical cure, microbiological cure, or mortality (P > 0.05 for all). Failure to achieve microbiological cure (P = 0.018) and receipt of immune-modulatory therapy (P = 0.01) were significantly associated with increased mortality. Significant cost variation was noted among the echinocandins. Considering the significant cost variation, comparable efficacies can be reassuring for the prescribing physician.
PURPOSE OF REVIEW: There is increasing incidence of renal cell carcinoma (RCC) with multiple treatment options currently available. The purpose of this review is to outline patient selection and technical approaches and present the current literature for percutaneous ablation of T1b (4.1-7 cm) RCC.
RECENT FINDINGS: An increasing number of retrospective studies and meta-analyses have evaluated the use of percutaneous ablation for T1b RCC. Overall, these studies tend to show that percutaneous ablation in this patient population is feasible. However, rates of major adverse events and local recurrence after percutaneous ablation for T1b RCC are both higher than when ablation is used for smaller tumors. As such, a multi-disciplinary, patient-centered approach is required. Due to the increasing literature in this area, the most recent National Comprehensive Cancer Network (NCCN) guidelines include percutaneous ablation as an option for non-surgical patients with T1b RCC.
Following surgery, patients start adjuvant radiotherapy 4-6 weeks after the operation, with a radiation dose of 45Gy/25F/5W, completed no later than 8 weeks post-surgery. Two weeks after completing radiotherapy, patients continue with immunotherapy maintenance therapy for up to 1 year (17 cycles Q3W) or until tumor progression.
During Phase 2a, participants in cohorts based on cancer type will receive oral cerdulatinib at starting doses of 35, 30, or 20 mg BID on Day 1 in 28-day cycles for up to 10 cycles. Doses of cerdulatinib can be reduced to a minimum dose of 15 mg BID or increased to a maximum dose of 30 mg BID at the discretion of the Investigator based upon clinical judgment and with Sponsor Medical Monitor approval.
PURPOSE:A vitamin C pharmaceutical, obtained by incorporating vitamin C with catalase, and having reduced and eliminated mutagenicity and cytotoxicity developed and increased by the reaction of the vitamin C with table luxuries. CONSTITUTION:A vitamin C pharmaceutical, obtained by incorporating vitamin C with catalase, and having reduced and eliminated mutagenicity and cytotoxicity. Any catalase derived from either one of animals such as the liver of cattle or horses or erythrocytes, etc. or plants may be utilized, and the ratio of the catalase to be incorporated may be 5-25 units based on 1mg vitamin C. The catalase is capable of reducing remarkably and eliminating the mutagenicity and cytotoxicity developed and increased by the reaction of the vitamin C with table luxuries, e.g. coffee, black tea or Bourbon whisky. The vitamin C pharmaceutical of this invention can be widely used in food industry and medical fields.
Pain invalidation involves the dismissal or lack of understanding of another's pain, undermining their subjective experience. Frequent exposure to invalidation negatively impacts mental and physical health as well as pain-related behaviors, potentially leading people to conceal their pain from others in the future and/or withdraw from potential sources of support. It is therefore possible that experiencing pain invalidation may also impact pain-reporting behavior in clinical settings. Across 2 separate samples of emerging adults, we examined whether exposure to invalidation of one's pain was associated with cognizant modulation of one's subjective acute pain ratings within routine medical and dental settings. Drawing upon social psychological theories of impression management and self-presentation, we hypothesized that exposure to pain invalidation would be associated with the under-rating of one's pain. In Study 1, previous experiences of invalidation were associated with under-rating of one's pain when visiting the doctor and the dentist. Study 2 found that invalidation from family and medical professionals-but not from friends-was associated with under-rating pain in both settings. Findings provide further evidence for the harmful effects of pain invalidation, particularly for emerging adults, as the dismissal of one's subjective experience may sow self-doubt while reinforcing cultural stigmas against pain, leading to alterations in pain communication that ultimately creates barriers to efficacious clinical treatment and care and increase pain-related suffering. PERSPECTIVE: Pain invalidation imparts harm to those who already suffer from pain, be it mentally, physically, and/or behaviorally. We show that people who have encountered invalidation are more likely to under-rate their pain when seeking care, impeding assessment and treatment, and further highlighting the importance of clinical validation of pain experiences.
The packaging contains a propellant under press. and a hair treatment composition in two parts which are admixed only when they are distributed by the packaging. One part comprises an aqs. oxidising dyeing base contg. an oxidising intermediate dyestuff or modifier selected from o-aminophenol, p-aminophenol, methyl-p-aminophenol, 5-nitro-2-aminophenol, 2:4-diaminophenol, N-(p-hydroxyphenyl)glycine, 8-hydroxyquinoline, 3-hydroxydiphenylamine, m-phenylenediamine, p-phenylenediamine, p-tolylenediamine, 2,4-diaminoanisole, pyrocatechol, resorcinol, hydroquinone pyrogallol, 1:3:5-trihydroxybenzene, 1:2:4:5-tetrahydroxybenzene, propyl gallate, beta-naphthol, 1:5-naphthalenediol, 2:7-naphthalenediol or their mixtures, the other part comprises an aqs. peroxide soln. At least one of these parts contains an alkalizations agent in amt. sufficient to give a pH of 7-12 to the mixed compsn the total amt. of dyestuff intermediate and modifier being sufficient to prevent the pressure due to liberated O2 becoming >10 atms of the two parts become mixed in the package. The two parts of the dyeing composition are separated by a membrane which ruptures more easily than the external walls of the packaging.
The left atrial appendage (LAA) is well known as a source of cardiac thrombus formation. Despite its clinical importance, the LAA neck is still anatomically poorly defined. Therefore, this study aimed to define the LAA neck and determine its morphometric characteristics. We performed three-dimensional reconstructions of the heart chambers based on contrast-enhanced electrocardiography-gated computed tomography scans of 200 patients (47% females, 66.5 ± 13.6 years old). The LAA neck was defined as a truncated cone-shaped canal bounded proximally by the LAA orifice and distally by the lobe origin and was present in 98.0% of cases. The central axis of the LAA neck was 14.7 ± 2.3 mm. The mean area of the LAA neck walls was 856.6 ± 316.7 mm2 . The LAA neck can be divided into aortic, arterial (the smallest), venous (the largest), and free surfaces. All areas have a trapezoidal shape with a broader proximal base. There were no statistically significant differences in the morphometric characteristics of the LAA neck between LAA types. Statistically significant differences between the sexes in the main morphometric parameters of the LAA neck were found in the central axis length and the LAA neck wall area. The LAA neck can be evaluated from computed tomography scans and their three-dimensional reconstructions. The current study provides a complex morphometric analysis of the LAA neck. The precise definition and morphometric details of the LAA neck presented in this study may influence the effectiveness and safety of LAA exclusion procedures.
Rationale: Each year, approximately 34,500 adults in The Netherlands sustain a fracture of the distal radius (wrist fracture). Incidence peaks in the elderly. The currently preferred treatment is closed reduction and nonoperative treatment by immobilization in a plaster cast for 4-6 weeks. Surgery is only performed if closed reduction fails or redislocation occurs. Plaster immobilization is inconvenient and interferes with daily activities. More importantly, standard nonoperative treatment often fails; in 40-60% of the fractures, redislocation requires surgery. Surgical treatment is about 9 times more expensive than nonoperative treatment and not without risks. This project aims to develop an innovative nonoperative treatment option. The central idea is to produce a 3D-printed brace for the fractured wrist using a mirrored CT-scan of the contralateral, unfractured wrist as a model. This innovative approach has the advantage that it does not depend on surgery and provides a better and potentially more durable positioning than the currently applied plaster cast. We expect that redislocation will occur less frequently, so surgery may be avoided. In contrast to a traditional plaster cast, the newly developed brace is water resistant/repellant, lighter, and enables movement of the hand. It enables daily activities and improves independency in the elderly with a wrist fracture. The treatment has been successfully evaluated in an ex vivo model. The clinical implementation will follow a step-wise approach.

Objective: Part 1 aims to determine the tolerability of the 3D-printed brace when worn by healthy volunteers (50 years of order), performing their normal daily activities. In part 2, the objective is to determine tolerability of the 3D-printed brace in patients (50 years or older) with an extra-articular distal radius fracture with dorsal displacement, performing their normal daily activities.
Disclosed is a device for preparation of liposomes, comprises a reaction tank and an infusion unit. The reaction tank comprises a collector mounted in a predetermined position of the reaction tank; Two inlet ports are included: the first inlet port for infusing an aqueous solution; and the second inlet port for infusing an organic solution. The infusion unit can introduce a bioactive agent containing-aqueous solution into the reaction tank. The infusion unit comprises a filter connected to one end of the infusion unit and being adjacent to the collector. The method using the device comprises the steps of infusing an aqueous solution and an organic solution into the reaction tank of the device and thus forming an interface between the filter and the collector; infusing a bioactive agent containing-aqueous solution and being filtered by the filter, the bioactive agent is encapsulated to form a water-in-oil emulsion; the water-in-oil emulsion is passing through the aqueous solution and thus to form a water-in-oil-in-water double emulsion. Finally the removal of the organic phase of water-in-oil-in-water double emulsion enables the harvest a plurality of liposomes. It has advantages such that simple-used and automation production. Thus nano size or sub-micro size liposomes can be prepared with high encapsulation efficiency without sonicators or delicate microfluidic systems.
PBN (α-phenyl-tert-butylnitrone), and its derivatives nitrone-based free radical traps, significantly reduce preneoplastic nodule development as well as inhibit hepatocellular carcinoma (HCC) formation at very low levels. The involvement of reactive oxygen speices (ROS) in cancer development has been strongly implicated for many years. The involvement of ROS has been strongly implicated in cancer development in a model system where feeding a choline deficiency (CD) diet to rats leads to hepatocellular carcinoma (HCC) development. Administering PBN in the drinking water inhibits HCC formation. Preneoplatic nodule growth in the liver is significantly suppressed by administering PBN, or some of its natural metabolites, in the diet. The effectiveness of PBN in preventing HCC development in the CD liver model is considered due to its prevention of tumor development after the target cells have already been initiated, i.e. genetically changed into tumor cells. Administration of PBN (or its potent derivatives) to humans that may already have microscopic tumor preneoplastic nodules should prevent the eventual frank tumor formation.
A randomized (4:1) expansion cohort will receive 3 cycles of drug (N=24) or placebo (N=6). A total of 30 patients will be accrued.
Technical advances over the past few years have rapidly increased the possibilities for filmless radiology services provided by picture archiving and communication systems (PACS). PACS is technology to eliminate film from radiology tests in the same way a desktop scanner is technology to eliminate paper in the radiology department. Paperless workflow will allow the radiology department to reduce medical errors, to improve access to critical information, to promote dynamic workload balancing across the department, to support decentralization, and to decrease interruptions. To move from the analog workflow (film, paper) to the digital (filmless, paperless) is main purpose of this workflow. Also it is focused on accelerating productivity for the radiology department and specialty practices, imaging centers, clinics, and hospitals. Paperless workflow will allow manager to reduce administration expenses such as paper, ink, and faxing. The number of employees who currently support a paper environment can drop dramatically after implementation of the new paperless workflow. New workflow can help healthcare organizations to reduce their cost and improve efficiencies.