anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine. SUBSTANCE: present invention describes tetrazole derivatives of general formula I:   wherein A is single bond or oxygen, alkenyl having 2-7 carbon atoms, phenylalkyl having 7-10 carbon atoms or alkyl having 1-6 carbon atoms optionally substituted with -COOR 2  in which R 2  is hydrogen or alkyl having 1-6 carbon atoms optionally substituted with CONR 3 R 4  in which R 3  and R 4  are the same or different and each is hydrogen or alkyl having 1-4 carbon atoms, or pharmaceutically acceptable salts thereof. The present invention also describes antiallergic composition which comprises compound of formula I in effective amount. Compounds have antiallergic and antiinflammatory activities and are useful as therapeutic agent for treating bronchial asthma, allergic rhenite, or the like. Besides, compounds are low toxic. EFFECT: improved properties of the antiallergic composition. 9 cl, 135 ex, 1 tbl
The present invention discloses small disturbance RNA for inhibiting theexpression of a multiple-effect growth factor gene and an application thereof. The aim of the present invention is to provide small disturbance RNA for inhibiting theexpression of a multiple-effect growth factor gene and an application of the small disturbance RNA as tumor treating drugs. The small disturbance RNA is a double-strand RNA sequence whose the positive-sense strand is SEQ ID No. 1 in a sequence list and the antisense strand is SEQ ID No. 2 in the sequence list. The coded sequence of the small disturbance RNA is the following double-strand nucleotide sequence: the positive-sense strand is SEQ ID No. 3 in the sequence list, and the antisense strand is SEQ ID No. 4 in the sequence list. The present invention has great practical meanings and wide application prospects in the fields of medicine and biologic pharmacy.
Participants will receive Methotrexate(MTX)+prednisolone. All participants in intervention arm will receive an initial dose of MTX 10 mg. The MTX will be increased to 15 mg the following week. Participants weighing less than 60 kg will continue to receive 15 mg of MTX weekly thereafter. Individuals weighing 60 kg or more will receive MTX 20 mg from week 8. At week 48 the MTX will be reduced to 10 mg for two weeks followed by 5 mg for two weeks and then stopped. In total participants will receive 52 weeks of MTX along side prednisolone, which will be the same as the control arm.
Patients will receive pulsed laser therapy using the HIRO 3 device (ASA Laser, Arcugnano, Italy) five times a week for 3 weeks, one session per day for a total of 15 sessions. The HILT device offers pulsed emission (1064 nm), very high peak power (3 kW), high fluence (energy density 360-1780 mJ/cm2), short duration (120-150 μs), average power of 10.5 W, low frequency (10-40 Hz), duty cycle of approximately 0.1%, a 0.5 cm diameter probe and a spot size of 0.2 cm. A standard handpiece equipped with fixed spacers is used to maintain the same distance from the skin. The 3-stage treatment program is planned to be applied to the 1st CMC joint area in each session.
Listening to natural auditory scenes leads to distinct neuronal activity patterns in the early visual cortex (EVC) of blindfolded sighted and congenitally blind participants.1,2 This pattern of sound decoding is organized by eccentricity, with the accuracy of auditory information increasing from foveal to far peripheral retinotopic regions in the EVC (V1, V2, and V3). This functional organization by eccentricity is predicted by primate anatomical connectivity,3,4 where cortical feedback projections from auditory and other non-visual areas preferentially target the periphery of early visual areas. In congenitally blind participants, top-down feedback projections to the visual cortex proliferate,5 which might account for even higher sound-decoding accuracy in the EVC compared with blindfolded sighted participants.2 In contrast, studies in participants with aphantasia suggest an impairment of feedback projections to early visual areas, leading to a loss of visual imagery experience.6,7 This raises the question of whether impaired visual feedback pathways in aphantasia also reduce the transmission of auditory information to early visual areas. We presented auditory scenes to 23 blindfolded aphantasic participants. We found overall decreased sound decoding in early visual areas compared to blindfolded sighted ("control") and blind participants. We further explored this difference by modeling eccentricity effects across the blindfolded control, blind, and aphantasia datasets, and with a whole-brain searchlight analysis. Our findings suggest that the feedback of auditory content to the EVC is reduced in aphantasic participants. Reduced top-down projections might lead to both less sound decoding and reduced subjective experience of visual imagery.
The invention discloses an auxiliary diagnosis and doctor advice success tracking system for sleep disorder. The system comprises a physiological sign data collection device, a patient end operation device and a server. The server includes a network communication interface, an application program interface module, an analysis data module, a database module and an order module. Through the physiological sign data from the patient end operation device, the reply data of the corresponding questionnaire and the patient log are analyzed by the doctor's advice module, doctors can know the instant condition of the patient and the effect of executing the doctor's advice. If the effect is out of the best, the auxiliary treatment course of self-healing of other self-discipline learning of the patient can be provided. The invention effectively strengthens the doctor-patient interaction and can strengthen the diagnosis and treatment of sleep disorder.
The intervention consists of 80mg of liquid gentamicin diluted in 5 mL normal saline (16mg/mL). The solution is injected by inserting a 22-gauge needle down to bone through an anteromedial approach at the level of the fracture site such that the injected solution fills the wound cavity. A total of 5mL of study solution will be administered.
This study is an adaptive, randomized, double-blinded, controlled trial to evaluate the safety and efficacy of therapeutic agents in hospitalized adult patients diagnosed with COVID-19. The study is a single-center trial that will be conducted in Shebin Elkom teaching hospital. The study will be a series of 3-arm comparisons between two different investigational therapeutic agents (Ivermectin and Hydroxychloroquine) and a placebo. There will be interim monitoring to allow early stopping for futility, efficacy, or safety. Because of the possibility that background standards of supportive care may evolve/improve over time as more is learned about the successful management of COVID-19, comparisons of safety and efficacy will be based on data from concurrently randomized participants. An independent data and safety monitoring board (DSMB) will actively monitor interim data to make recommendations about early study closure or changes to study arms.
The usual starting dose of glimepiride as initial therapy is 1-2 mg once daily, administered with breakfast or the first main meal. Those patients who may be more sensitive to hypoglycemic drugs should be started at 1 mg once daily, and should be titrated carefully. (See PRECAUTIONSSectionforpatientsatincreasedrisk.) 

No exact dosage relationship exists between glimepiride and the other oral hypoglycemic agents. The maximum starting dose of glimepiride should be no more than 2 mg. 

Failure to follow an appropriate dosage regimen may precipitate hypoglycemia. Patients who do not adhere to their prescribed dietary and drug regimen are more prone to exhibit unsatisfactory response to therapy.
Examples relate to surgical microscope systems, and to corresponding systems, methods, and computer programs for surgical microscope systems. The system includes one or more processors and one or more storage devices. The system is configured to track the progress of the surgical procedure. The system is configured to select two or more of the plurality of functions of the surgical microscope system based on the progress of the surgical procedure. The system is configured to assign two or more functions to two or more input modalities of the surgical microscope system. The system is configured to generate a visual overlay of a visual representation having two or more functions. The two or more functions are displayed in relation to visual representations of the two or more input modalities. The system is configured to provide a display signal to a display device of the surgical microscope system, the display signal including a visual overlay.
A method of diagnosing glaucoma using machine learning methods comprises determining a labeled training data set. The labeled training data set comprises electroretinography (ERG) signals measured from a group of subjects. The ERG signals are labeled either glaucomatous or non-glaucomatous based on the subject from which each ERG signal was measured. The training data set is used to train a machine learning model, such as a decision tree model, a discriminant model, a support vector machine, a nearest neighbor algorithm, or an ensemble classifier. The resulting trained machine learning model is configured to classify an ERG signal input as glaucomatous or non-glaucomatous. The model can be employed by measuring an ERG from a subject and inputting the measured ERG into the trained machine learning model. The subject can be diagnosed as having glaucoma based on an output classification of glaucomatous.
PURPOSE: To investigate how commonly adolescent psychiatric outpatients with symptoms of depression and anxiety report having been subjected to sexual harassment, and to explore how symptoms and functional abilities differ between adolescent psychiatric outpatients with symptoms of depression and anxiety who do report and those who do not report having been subjected to sexual harassment.
METHODS: Swedish adolescent psychiatric outpatients with symptoms of depression or anxiety (n = 324; 66 boys and 258 girls, aged 12-19 years, M = 15.6, SD = 1.7) answered the PROMIS paediatric measures. Logistic regression analyses were performed to assess differences between the respondents classified as 'Sexually harassed' and 'Not sexually harassed' based on these self-report questionnaires.
RESULTS: About 60% of the adolescents reported having been subjected to sexual harassment, and reported higher levels of suicidal ideation, disturbed sleep, fatigue, anxiety, depression, anger, and pain interference, as well as lower functional ability in terms of school problems, alcohol consumption, and poor family relationships. Logistic regression analyses showed that the strongest associations were with suicidal ideation, disturbed sleep, anger, and alcohol consumption.
CONCLUSIONS: About 60% of the adolescents in the studied psychiatric cohort reported having been subjected to sexual harassment. Reported experiences were high in all three subtypes, with the most reports on having been subjected to verbal harassment. Clinicians should ask about experiences of sexual harassment and give information about the consequences of sexual violence and treatment options. Alcohol consumption should be addressed and tested for. Structured assessment of suicidality should always be done.
BACKGROUND: The aim of this study is to examine the relationship between the frequency of use of non-medication coping strategies with urinary incontinence (UI) and depression in older adults.
METHODS: This study followed a descriptive design and was conducted with 345 older adults over the age of 65. The data of the study were collected using the Geriatric Depression Scale Short Form and the Frequency of Non-Medication Coping Strategies with Urinary Incontinence Scale. The data analysis of the study was conducted using descriptive statistics, Pearson correlation analysis, and hierarchical multiple regression analysis. The significance level was accepted as P < 0.05.
RESULTS: The mean age of the participants was 71.86 ± 5.43 years. Among the older adults, 58.8% were male and 50.2% were primary school graduates. It was determined that 43.8% of the participants experienced the frequency of UI more than once a week, 36.2% experienced stress incontinence, 51.9% consulted a physician due to UI, 53.6% received treatment for UI, and 47.8% reported that UI had an impact on their social life. The relationship between the frequency of use of non-medication coping strategies with UI and geriatric depression (β = -0.017; P = 0.043) was found to be significant and negative. It was found that there was a significant and positive relationship between age, frequency of UI, type of UI, the impact of UI on social life, and geriatric depression (P < 0.05).
CONCLUSION AND SUGGESTIONS: The older adults in this study were found to have moderate depression. It was determined that the level of depression was higher in the older adults who experienced UI more than once a week, those who experienced stress UI, those whose social lives were impacted, and those who had a higher frequency of non-medication coping strategies.
PURPOSE: A composition containing emodin for preventing and treating alcoholic-induced teratogenesis is provided to recover value of cGPx(glutathione peroxidase) and SOD1(superoxide dismutase1). CONSTITUTION: A composition for preventing and treating alcohol-induced teratogenesis contains emodin(1,3,8-trihydroxy-6-methylanthraquinone) as an active ingredient. The emodin is isolated from aloe. The composition recovers organogenesis and growth of fetus. A daily dose of emodin is 0.001~100 mg/kg. A food composition for preventing and treating alcohol-induced teratogenesis contains 0.0001-10 weight% of emodin as an active ingredient.
Age-Matched Controls without immune mediated skin diseases. Peripheral blood and/or check swabs will be collected from participants ages 12- 85 years old. These samples will then be used to characterize the inflammatory cells as described above.
Within the United States, approximately 330 000 military veterans die annually, but only 5% of deaths occur in Veterans Health Administration (VHA) facilities. To help provide end-of-life care for veterans, the VHA built community partnerships with community hospice and palliative care (HPC) organizations. Veterans experience unique psychosocial factors making it vital to ensure HPC organizations have access to veteran-specific knowledge and resources to reduce suffering. To better understand the strengths and limitations of these partnerships, community HPC staff (N = 483) responded to quantitative and qualitative survey questions developed using an access to care theory for veterans. Survey responses demonstrated variable perceptions of access to VHA care and resources. Respondents reported excellent experiences (44%) and relationships with their local facility (50%) and had a reliable contact who provided needed assistance (92%). Thematic analysis identified a need for VHA care and barriers to access, which were associated with technical characteristics, and geographical and cultural issues. These findings can help inform future research and policy regarding access to VHA resources for end-of-life care for veterans in the community and guide resource development for community HPC providers.
The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibility to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and follow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti-CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL.
Laparoscopic appendectomy is a common procedure in pediatric surgery. For single incision laparoscopic appendectomy (SILA), the laparoscope and other instruments are inserted with the aid of a large trocar through a single umbilical incision. Laparoscopic appendectomy via a single umbilical incision is a less invasive procedure associated with minimal or no scarring compared to the traditional laparoscopic operation. Postoperative pain, nausea and vomiting are common problems encountered with laparoscopic appendectomy and other abdominal operations. As an established standard practice at Texas Children's Hospital, pain control in these patients is achieved by intravenous opioids via a patient controlled device along with ketorolac tromethamine, as well as local anesthetic infiltration (LAI) performed by surgeon or bilateral rectus sheath blocks as described below.

The umbilical area is innervated by the bilateral 9th, 10th and 11th intercostal nerves, which run between the internal oblique and transversus abdominis muscle. At the lateral edge of the rectus muscle, the nerves perforate the rectus sheath and innervate the rectus muscle. Anterior cutaneous branches cross the muscle supplying the skin of the umbilical area. Successful blockade of the relevant intercostal nerves within the rectus sheath can provide effective pain relief for umbilical and other midline surgical incisions. Rectus sheath block has also been shown to give better pain control when compared with intra-incisional infiltration and intra-peritoneal injection in patients undergoing laparoscopic gynecologic surgery. Recently, it has been shown that there is improved efficacy and a decreased local anesthetic requirement when ultrasound is used to guide rectus sheath block in children undergoing umbilical hernia repair. However, data comparing pain after ultrasound guided bilateral rectus sheath block (UGBRSB) and peri-umbilical local anesthetic infiltration (LAI) for SILA are not available. The incidence of postoperative nausea and vomiting (PONV) is high after laparoscopic surgery, with a dose-related increase noted when opioids are used in the postoperative period. Effective regional anesthesia may decrease opioids use and consequently reduce the incidence of PONV and improve patient satisfaction.
An apparatus and method for a feature extraction network based brain machine interface is disclosed. A set of neural sensors sense neural signals from the brain. A feature extraction module is coupled to the set of neural sensors to extract a set of features from the sensed neural signals. Each feature is extracted via a feature engineering module having a convolutional filter and an activation function. The feature engineering modules are each trained to extract the corresponding feature. A decoder is coupled to the feature extraction module. The decoder is trained to determine a kinematics output from a pattern of the plurality of features. An output interface provides control signals based on the kinematics output from the decoder.
150 HCC patients with tumor \>5cm, multiple tumor and who cannot accept R0 resection will be randomized divided into 3 groups. Group A (50 cases) will be implanted 600mg sustained released 5-FU into liver incisal margin after tumor is resected. Group B (50 cases) will be implanted 600mg sustained released 5-FU and 60mg sustained released cisplatin. Group C (50 cases) will be the controlled one which will not be implanted any chemotherapeutic drugs. All patients will accepted TACE 30 days after liver resection. We will follow up all patients until they are dead or missed connected. Related adverse reaction will be recorded. Total survival time (TST) and disease free survival time (DFST) will be calculated too. At the end of the study we will compare the difference of adverse reaction, complication, TST and DFST between the 3 groups. According to the result we will estimate these drugs' antitumor effect and safety.
FIELD: medicine. SUBSTANCE: method involves administering Akonit or Belladonna or Ferrum phosphoricum during the initial period of illness when high temperature is observed, Baptisia when intoxication phenomena are observed. The preparations are changed according to patient state. Wet fine bubbling rale taking place, tartarius emeticus is to be administered. Medium or large bubbling rale taking place, ipecacuanha is to be administered. Spastic cough paroxysms taking place, Drosera is to be administered. Weak breathing above the medium and inferior lobes being detected, Kali carbonicum, phosphorus or Arsenicum or its derivatives are to be administered. Weak breathing above the inferior lobe to its left being detected, Sodium sulfuricum or other sulfur derivatives are to be administered. Weak breathing above the apex pulmonis to the right being detected, Ferrum phosphoricum is to be administered. Weak breathing above the apex pulmonis to the left being detected, ammonium preparations or Hepar sulfuricum are to be administered. Diffuse breathing weakening being detected over the whole lung surface, Drosera preparations or Alumina or tartarius emeticus are to be administered. Lingering process and weak sputum discharge being observed, Asclepias tuberosa is to be administered. Rumex or pulmonary Sticta or Senega are to be administered during the resolution phase of the illness. Camphora is administered during the whole treatment course to every patient. EFFECT: enhanced effectiveness of treatment course.
Group 3 will receive standing retraining with BWS with electrical stimulation, followed by 15 min of overground training. Locomotor training consists of (step training and stand retraining) on the treadmill, over ground training, and community ambulation. BWS will be given when a subject can not maintain his/her body weight while executing limb locomotion. Electrical stimulation will start while participant is seated and before he/she is brought up to full standing. There will be 60 sessions/3x week for 20 weeks.