anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: To evaluate margin positivity at apex utilizing preoperative magnetic resonance imaging [MRI], micro-ultrasound [MUS], prostate specific membrane antigen positron emission tomography PSMA PET] scan, biopsy location and intraoperative timing of deep venous complex [DVC] ligation during robot assisted radical prostatectomy [RARP].
METHODS: Institution review board approved retrospective study underwent RARP between November 2022 to March 2024. All patients underwent preoperative MRI, MUS and PSMA PET scan. Patients underwent RARP using either standard DVC [done prior apical dissection] ligation or delayed DVC [after prostate removal] technique. All patients underwent intra operative frozen section analysis by an experienced genitourinary pathologist. Descriptive statistics were performed. Data analyzed using R software version 4.3.3.
RESULTS: Total 619 prostate cancer patients underwent RARP. Of these, 365 men underwent RARP using delayed DVC ligation technique and 254 men using standard DVC ligation technique. There was no statically significant difference in 2 groups on demographic parameters, MRI, MUS and PSMA-PET scan features. Sensitivity of MRI, MUS, PSMA-PET and prostate biopsy for detection of apical positive margin were 66%, 81%, 81% and 73% respectively. Specificity of MRI, MUS, PSMA-PET and prostate biopsy for detection of apical positive margin were 45%, 14%, 16% and 30% respectively. When all modalities are used accumulatively, apical cancer was missed only in 1% of cases.
CONCLUSIONS: With proper preoperative understanding of apical lesion location, timing of DVC ligation [standard vs delayed] doesn't impact apical positive surgical margins. Combination of MRI, MUS, PSMA-PET and prostate biopsy reduce apical positive surgical margin rates significantly.
OBJECTIVES: Recurrent Clostridioides difficile infection (CDI) poses healthcare challenges and morbidity. Preventing recurrence with prophylactic oral CDI antibiotics lack consensus.
METHODS: We used data from the largest healthcare provider in Israel to identify all adults aged 18 years or older diagnosed with a first episode of CDI (Index CDI) between February 2018 and December 2022 and subsequently received a non-CDI antibiotic within 2-8 weeks. Patients who received a concurrent prophylactic CDI antibiotic constituted the CDI prophylaxis group. Multivariable Cox proportional hazard regression models were used to examine the association of secondary CDI prophylaxis with CDI recurrence according to the severity of the index CDI (primary objective) and with 4- and 8-week all-cause mortality (secondary objective).
RESULTS: A total of 434 eligible patients were included. Among them, 327 did not receive CDI antibiotic prophylaxis, while 107 did. CDI antibiotic prophylaxis was associated with a significant risk reduction of CDI recurrence with an adjusted HR of 0.51 (95% CI, 0.27-0.97). The magnitude of the association was modified by the severity of the index CDI episode (P for interaction 0.0182). Specifically, the HR for recurrence was 0.163 (95% CI 0.045-0.593) for non-severe CDI, and 1.242 (95% CI 0.524-2.946) for severe CDI. No significant association was found between CDI antibiotic prophylaxis and 4-8 weeks mortality.
CONCLUSION: Secondary prophylaxis with CDI antibiotics appears to be associated with a reduced risk of recurrence in patients with previous non-severe CDI episode. Further studies are needed to confirm this finding.
Psychiatric symptoms ranging from anxiety, paranoia, and depression to hallucinations and psychotic behavior can occur with mefloquine use. Symptoms may occur early in the course of mefloquine use. In some cases, these symptoms have been reported to continue for months or years after mefloquine has been stopped. Cases of suicidal ideation and suicide have been reported.

Mefloquine should not be prescribed for prophylaxis in patients with active depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders. Mefloquine should be used with caution in patients with a previous history of depression.

During prophylactic use, the occurrence of psychiatric symptoms such as acute anxiety, depression, restlessness or confusion suggest a risk for more serious psychiatric disturbances or neurologic adverse reactions. In these cases, the drug should be discontinued and an alternative medication should be substituted.
At W0, ADA administration will be continued every 14 days. At W24, the control arm will continue to receive ADA every 14 days regardless of serum ADA concentration.
Eight exercises will be used to include large upper and lower body muscle groups. The baseline 1 repetition maximum (RM) will be used to set initial training loads. All exercise sessions will be performed under the supervision of an exercise physiologist. Vital signs and body weight will be recorded before each session. The workload during training will be adjusted to reflect 80% of the most recent 1 RM (approximately 8-12 RM set). In addition, patients' workloads will be progressively increased if the patients can lift the weight more than 12 repetitions. Participants will perform three sets of 8-12 repetitions on each machine per session.
INTRODUCTION: After two-stage exchange due to prosthetic joint infection (PJI), the new prosthesis carries a high risk of reinfection (RePJI). There isn`t solid evidence regarding the antibiotic prophylaxis in 2nd-stage surgery. The objective of this study is to describe what antibiotic prophylaxis is used in this surgery and evaluate its impact on the risk of developing RePJI.
METHODS: Retrospective multicenter case-control study in Spanish hospitals. The study included cases of PJI treated with two-stage exchange and subsequently developed a new infection. For each case, two controls were included, matched by prosthesis location, center, and year of surgery. The prophylaxis regimens were grouped based on their antibacterial spectrum, and we calculated the association between the type of regimen and the development of RePJI using conditional logistic regression, adjusted for possible confounding factors.
RESULTS: We included 90 cases from 12 centers, which were compared with 172 controls. The most frequent causative microorganism was Staphylococcus epidermidis with 34 cases (37.8%). Staphylococci were responsible for 50 cases (55.6%), 32 of them (64%) methicillin-resistant. Gram-negative bacilli were involved in 30 cases (33.3%), the most common Pseudomonas aeruginosa. In total, 83 different antibiotic prophylaxis regimens were used in 2nd-stage surgery, the most frequent a single preoperative dose of cefazolin (48 occasions; 18.3%); however, it was most common a combination of a glycopeptide and a beta-lactam with activity against Pseudomonas spp (99 cases, 25.2%). In the adjusted analysis, regimens that included antibiotics with activity against methicillin-resistant staphylococci AND Pseudomonas spp were associated with a significantly lower risk of RePJI (adjusted OR = 0.24; 95% IC: 0.09-0.65).
CONCLUSIONS: The lack of standardization in 2nd-satge surgery prophylaxis explains the wide diversity of regimens used in this procedure. The results suggest that antibiotic prophylaxis in this surgery should include an antibiotic with activity against methicillin-resistant staphylococci and Pseudomonas.
Virtual site inspections to support clinical trials is disclosed. A frame and glasses subsystem has at least a global positioning system (GPS) and is associated with a first computing device at a physical site where an inspection is conducted. A session is opened in a web-based application on a second communication device that is in communication with, but that is physically remote from, the first computing device. Location tracking using GPS allows for a location of the frame and glasses subsystem to be continuously tracked. A script from the web-based application to the first computing device enables association with a video stream and locations within the physical site. The script enables responses to be provided from the first computing device at the locations. The locations, time stamps, video stream, the responses from the script, and a device identifier is provided immutably to the web-based application.
Dental bridge framework parts are made in the mouth on framework parts, or on working models using a paste-form hardenable mixt. of precious metal solder powder and a combustible binder. The solder powder is composed of (wt.%); Au 40-90; Ag 5-50; Pt or Pd 2-20; and Rh or Ir 0-10 and is of spherical or splinter shaped particles of average particle size 10-250 microns. The binder is a wax or thermoplastic which softens on heating. The hardenable solder is applied via a spray nozzle, then in the second stage a fixing paste is applied. This is a fibrous structured material based on Al2O3 and stable up to 1300 deg.C, which when mixed has a highly tenacious consistency and hardens on drying. The fixing paste is applied in strand form from a nozzle (dia. 1.5mm) to mechanically retain the framework and make it stress free. USE/ADVANTAGE - Simple and economic method, avoids the labour intensive features of other processes, also avoids high mechanical pressure, point welding, and a stressed structure.
Initially, ZOLADEX, like other GnRH agonists, causes transient increases in serum levels of testosterone in men with prostate cancer, and estrogen in women with breast cancer. Transient worsening of symptoms, or the occurrence of additional signs and symptoms of prostate or breast cancer, may occasionally develop during the first few weeks of ZOLADEX treatment. A small number of patients may experience a temporary increase in bone pain, which can be managed symptomatically. 

As with other GnRH agonists, isolated cases of ureteral obstruction and spinal cord compression have been observed in patients with prostate cancer. If spinal cord compression or renal impairment secondary to ureteral obstruction develops, standard treatment of these complications should be instituted. For extreme cases in prostate cancer patients, an immediate orchiectomy should be considered.
OBJECTIVE: This study is aiming to compare the results of early and late removal of urinary catheters after rectal cancer surgery.
MATERIALS AND METHODS: Patients who undergone rectal cancer surgery in a single center were included in this prospective randomized study. The timing of the urinary catheter removal was randomized by a computer-assisted program and divided into 2 groups, which are early (first 48 h) and late (after 48 h). The primary outcome of this study was to compare the urinary retention and re-catheterization rates between patients with early and those with late catheter removal.
RESULTS: Sixty-six patients were included in this study. The median age was 60 (31-88 years), and the patient group was predominantly male (n: 40, 60.9%). Urinary retention after catheter removal developed in 8 (12%) of 66 patients. There was no difference between the two groups in terms of the need for re-catheterization (14% vs. 10%, p: 0.63). All the patients who required re-catheterization (n: 8) and were discharged with a urinary catheter (n: 4) were male. When the male and female patients were evaluated separately, there was no difference in urinary retention in the early or late groups.
CONCLUSIONS: Early or late removal of the catheter does not play a role in the development of urinary retention in patients undergoing rectal cancer surgery.
An initial cohort of 13 participants will receive 2 cycles of drug or placebo per the schedule below under carefully monitored conditions, including examinations to observe and document administration site reaction following consecutive administration cycles of the drug. 10 participants will receive drug and 3 will receive placebo. The safety stopping rule is to implement an enrollment pause if 2 dose limiting toxicity (DLT, see section 5.1) out of the first six or 3 DLTs out of the first 10 participants receiving drug are observed in either cycle 1 or cycle 2. The independent DSMB will conduct a review of the safety data to determine the relatedness of the DLTs to the drug exposure and provide a recommendation to continue. Thus, if safety events are determined to be not (or unlikely) related to drug exposure the trial may resume. The independent DSMB will review safety and tolerance data before the study can continue.

If at most 2 DLTs out of the 10 participants receiving drug are observed, then a Phase Ib expansion cohort will open. The expansion cohort will receive 3 cycles of therapy. A total of 30 participants will be accrued and randomized 4:1 to receive drug (N=24) or placebo (N=6). There will be extensive assessment of toxicity and an early stopping rule to implement an enrollment pause and independent DSMB review of safety data to determine relatedness to drug exposure for recommendation of trial continuation, will be employed as above. Safety and tolerability will be the primary endpoint but secondary endpoints include changes in immunological parameters.
The invention relates to a pure traditional Chinese medicine composition, in particular to a Chinese herba preparation of momordica grosvenori tea for relieving coughs and reducing sputum. The Chinese herba preparation of the momordica grosvenori tea comprises, by weight, 10-80 parts of momordica grosvenori, 5-30 parts of radix ophiopogonis and 5-50 parts of mussaenda pubescens ait.f., and preferably the Chinese herba preparation of the momordica grosvenori tea comprises, by weight, 50 parts of momordica grosvenori, 10 parts of radix ophiopogonis and 15 parts of mussaenda pubescens ait.f.. Clinical applications show that the Chinese herba preparation can be used for clearing away heat and toxic materials, cooling blood and subsidence of a swelling. The Chinese herba preparation is used for quickly clearing heat, moistening lungs, relieving coughs and reducing sputum. The Chinese herba preparation is used for the symptoms such as coughs, excessive phlegm, sun drying, fever, toothache, hot eyes and constipation caused by phlegm-heat obstructing lungs of acute bronchitis. There is no need for patients to take medicine for a long time, and no obvious side effect can be caused. The Chinese herba preparation of the momordica grosvenori tea is definite in curative effect, and the symptoms treated by the Chinese herba preparation are common diseases and frequently-occurring diseases caused by internal heat. The Chinese herba preparation of the momordica grosvenori tea is wide in application people, suitable for both the young and the old, good in product mouthfeel, and capable of being taken (taken after being mixed with water or taken in a sublingual mode), carried and stored conveniently.
Iodine is an essential component of thyroid hormone, which is necessary for many metabolic processes as well as the maturation of the CNS. Deficiencies of iodine have deleterious effects on both pregnant women and infants. The iodine status of the population after implementation of the universal salt iodization program in Zhejiang province has not been known. This study was to determine whether pregnant women show evidence of iodine deficiency, and to examine the correlation between maternal urine iodine concentration and newborn thyroid function.

Healthy women at 12 weeks' gestation and over from four different areas in Zhejiang province were enrolled to participate this program from May 2007 to May 2010. Women consented to provide urine samples and salt samples during pregnancy (12, 16, 24 weeks' gestation and before delivery), and give permission to access their newborn's TSH value. Urinary iodine concentration (UIC) was determined by ammonium persulfate digestion microplate method, and TSH was determined by a time resolved fluoro-immunoassay (TRFIA). The diagnostic standard for congenital hypothyroidism was: TSH ≥ 20 mU/L and declined FT4 levels. Compare the correlation to effects with different level of iodine content in salt, maternal UIC and neonatal TSH. Investigate the optimal level of iodine content in salt in different areas in ZheJiang province.
Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are the primary factors that regulate IMF content. Intramuscular adipocytes can be derived from either in situ or ectopic migration. In this study, it was discovered that the regulation of IMF levels is achieved through the chemokine (C-C motif) ligand 5 (CCL5)/chemokine (C-C motif) receptor 5 (CCR5) pathway by modulating adipocyte migration. In coculture experiments, C2C12 myotubes were more effective in promoting the migration of 3T3-L1 preadipocytes than C2C12 myoblasts, along with increasing CCL5. Correspondingly, overexpressing the CCR5, one of the receptors of CCL5, in 3T3-L1 preadipocytes facilitated their migration. Conversely, the application of the CCL5/CCR5 inhibitor, MARAVIROC (MVC), reduced this migration. In vivo, transplanted experiments of subcutaneous adipose tissue (SCAT) from transgenic mice expressing green fluorescent protein (GFP) provided evidence that injecting recombinant CCL5 (rCCL5) into skeletal muscle promotes the migration of subcutaneous adipocytes to the skeletal muscle. The level of CCL5 in skeletal muscle increased with obesity. Blocking the CCL5/CCR5 axis by MVC inhibited IMF deposition, whereas elevated skeletal muscle CCL5 promoted IMF deposition in obese mice. These results establish a link between the IMF and the CCL5/CCR5 pathway, which could have a potential application for modulating IMF through adipocyte migration.NEW & NOTEWORTHY C2C12 myotubes attract 3T3-L1 preadipocyte migration regulated by the chemokine (C-C motif) ligand 5 (CCL5)/ chemokine (C-C motif) receptor 5 (CCR5) axis. High levels of skeletal muscle-specific CCL5 promote the migration of subcutaneous adipocytes to skeletal muscle and induce the intramuscular fat (IMF) content.
One PD P 506 A-patch will be administered to each great toenail for 4 hours. After removal of the study medication the study nail(s) s will be illuminated with red light of defined wavelength (PDT).
PURPOSE:To obtain a multi-layer cosmetic emulsifiable by shaking to exhibit beautiful appearance, quickly separable into multiple layers when left at rest and having excellent safety to skin, etc., by using pyroglutamic acid peptide, dipropylene glycol, a surfactant and water as main components. CONSTITUTION:The objective multi-layer cosmetic is composed mainly of 28-75wt% compound of formula I (R is H, CH3, isopropyl, hydroxymethyl, benzyl, group of formula II, HOOC-CH2-, group of formula III, etc.; n is 1-5; M is H or alkali metal), 4-32% dipropylene glycol, 5-33% surfactant and 11-47% water. The cosmetic is separated into transparent multiple layers when left at rest and is emulsified by shaking to exhibit beautiful appearance. Furthermore, it has excellent practical properties such as affinity, spreadability and moistening feeling to the skin and is free from skin irritation. The surfactant is preferably a nonionic surfactant having an HLB value of 8-12.
The present invention provides a novel natural botanical herbal preparation based on the synergistic effect of 20 plant part extracts. It can be used for preventing and treating various coronary heart disease risk factors, including vascular inflammation process causing cardiovascular events. The plant extract comprises the following parts: salvia, sage, walnut, horse chestnut and ginger root, cinnamon bark, sesame, papaya, black grass, pomegranate seeds, cornflower leaves, frankincense pistacia resin, coconut nuts, cocoa beans, date palm dried pulp and kernels, olive, fig, walnut, blueberry dried pulp, garlic cloves and rose petals. The present invention treats the above plant parts with 70% ethanol at 70-80 deg.C and maintains the pH of the solution between 7-10, separates the active compounds using chromatography and spectroscopy and detects the molecular characterization of the plant extract. The formula has been proved to have the effects of reducing blood fat, resisting obesity, atherosclerosis, oxidation, anxiety and cysteine through experiments. The test drug may also ameliorate endothelial dysfunction, and is therefore suggested as an effective remedy for preventing/reducing adverse cardiac disease.
Non-specific neck pain is defined as pain in the posterior and lateral part of the neck between the superior nuchael line and the spinous process of the 1st thoracic vertebra, without neurological findings and obvious structural pathology. It is more common in women than in men. Neck pain is thought to affect upper extremity functions. Although the exact cause is unknown, it has been reported that mechanical loading, minor peripheral nerve damage and deconditioning negatively affect upper extremity functions in individuals with neck pain and reduce the quality of life. Although it is stated in the literature that patients with neck pain often experience upper extremity problems, there are a limited number of studies evaluating the relationship between the neck and upper extremity.

This study was planned to determine upper extremity functions and their impact on health-related quality of life in female patients with NSHP. Female patients with NSHP over the age of 18 who apply to Tarsus State Hospital Physical Therapy and Rehabilitation Clinic, meet the inclusion criteria, and agree to participate in the study will be included in the study. With our research, patients' upper extremity functions (hand skills, hand and finger grip strength, reaction time, position sense, upper extremity strength and endurance) and health-related quality of life will be evaluated and interpreted.
The present invention relates to a functional carbonic acid fermentation enzyme, a fermentation method, and a composition thereof. Fruits, vegetables, grains, and medicinal plants are fermented by an enzyme, and are consumed as beverages by being mixed in water. However, the beverages are extracts in which sugar is not smoothly fermented and which is not sufficiently fermented. According to the present invention, fermented enzyme ingredients are secondly to fifthly fermented to age and ferment sugar, and fructooligosaccharide is added, sealed, and fermented during second fermentation. When gas is filled, the gas is discharged, and the fermented ingredients are fermented by carbonic acid. To ensure fresh and savory tastes, 1-3 fermented materials of firstly fermented lemon, citron, pine needles, pomegranate, Schisandra, quince, and blueberries are made into mixed tea, and the mixed tea is added. Thistles are added as a basic material for ensuring a detoxifying function by a liver function activity. Catbrier is added as a material for discharging inter-material side effect heavy metals. Japanese apricots are added to improve gastrointestinal functions and to prevent wrinkles on elastic skin. Raspberry leaves are added as a material for managing inflammation of oral diseases. Cornus fruits are added as a material for improving immunity. A thermal extract is added, and the ingredients are fermented into a beverage. A fermented enzyme composition of the present invention is used in relieving fatigue, improving a liver function, managing skin and scalp aging, improving immunity, improving gastrointestinal functions, sterilizing oral gum, and alleviating oral diseases. The fermented enzyme composition is used as a carbonic acid fermentation enzyme beverage (alcohol) for comprehensively managing health and as a cosmetic product raw ingredient.