anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PCT No. PCT/EP91/01108 Sec. 371 Date Feb. 11, 1993 Sec. 102(e) Date Feb. 11, 1993 PCT Filed Jun. 14, 1991 PCT Pub. No. WO91/19785 PCT Pub. Date Dec. 26, 1991The present invention relates to a retrovirus isolated from a chimpanzee and designated as SIVcpz-ant and to variants of this virus, having the following essential morphological and immunological properties: the virus exhibits a tropism for T4 lymphocytes, the virus does not exhibit cytopathic effect with the formation of giant cells in the lymphocytes that it infects, the virus has a diameter of approximately 130 nm, the virus possesses a magnesium dependent reverse transcriptase activity, it can be cultivated in T4 receptor-bearing immortalized cell-lines, lysates of the virus containing a p27 protein that is immunologically distinct from the p25 of HIV-1 and p19 protein of HTLV-1 on Western Blot, lysates of the virus containing a gp140 protein which is immunologically distinct from the gp120 of HIV-1 and gp140 of HTLV-1 by Western Blot analysis, the lysate of the virus contains an additional transmembrane glycoprotein with a molecular weight of 44,000 to 50,000 kD.
A resin composition for denture base, which the impact resistance is strengthened, is provided to prevent the transparency and ensure excellence of compatibility with PMMA and impact resistance. A resin composition for denture base comprises a liquid component containing a sensual monomer and a solid component containing a cross-linking agent, PMMA(Poly methyl methacrylate), initiator, and core-shell particle for impact resistance. The core-shell particle comprises a core of urethane resin, PMMA, and a shell of high affinity, and is mixed in a 5% by weight. The molecular weights of core and shell materials are 100,000-1,000,000 and 100,000-1,000,000, respectively. The size of the core-shell is 20-400 nm. The core-shell particle is manufactured by emulsion polymerization.
Participants will undergo 6 months of gonadotropin releasing hormone agonist (GnRHag) therapy (intramuscular injection of leuprolide acetate 3.75 mg for depot suspension; Lupron; TAP Pharmaceutical Products, Inc.; Lake Forest, IL) to chronically suppress ovarian hormones. A single injection of leuprolide acetate produces an initial stimulation (for up to 3 wk) followed by a prolonged suppression of pituitary gonadotropins and ovarian hormones. Repeated monthly dosing suppresses ovarian hormone secretion.
1335181 Antineoplastic substance E M COBB 19 April 1971 [8 Nov 1969] 54800/69 Heading A5B An antineoplastic substance is obtainable from plants of the Compositae family Tribe: Cynareae. Subtribe: Centaureineae, by fractionating juice or a solvent extract of the plant. The preferred species is Carduus benedictus. The leaves, stem, flowers, fruit, seeds or roots may be used. The original plant material or juice is preferably stored under refrigeration or deep freezing and/or with the addition of a conservation substance. The juice may be obtained by macerating the plant and separating the solid and liquid portions. The solvent extract may be obtained by grinding fresh or dried plant material and extracting it with successive portions of solvent, steeping it in the solvent or allowing warm solvent to percolate through it. The solvent may be chloroform or ethanol. Where ethanol is used, it is subsequently partitioned with chloroform. The juice or solvent extract may be concentrated by vacuum distillation. The fractionation may be by chromatography or electrophoresis guided by in vitro or in vivo test. The product may be mixed with a carrier or diluent to provide tablets, capsules, cachets, granules, powder or an injectable dispersion of pharmaceutical use.
A pharmaceutical composition for oral administration comprising as an active ingredient a combination of materials derived from plants. The combination includes plants from the following species - Andrographis paniculata, Tinospora Cordifolia, Eclipta alba, Tephrosia purpurea, Vitex negundo, Zingiber officinale, Terminalia chebula and VVithania somnifera. Fragments of whole plant may be used, such as stem, root, leaf, seed or bark. Extracts obtained from such plants may also be used. The composition may take the form of a powder, pellets, a liquid or be made into a feed or chew for animals. Methods for preparing such a composition and the use of such a composition in therapy of animals are also provided. The composition has been found to be active against liver disease, arthritis, urinary tract infection and respiratory disease.
PCT No. PCT/EP95/00155 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed Jan. 17, 1995 PCT Pub. No. WO95/22333 PCT Pub. Date Aug. 24, 1995The invention concerns a method for producing a sterile prednisolone gel. The method is characterized in that prednisolone or its pharmaceutically acceptable ester is sterilized and incorporated into a sterile polyacrylate gel, which has been per se conventionally produced, in appropriate amount under aseptic conditions, or else the sterile prednisolone or its pharmaceutically acceptable ester is suspended in a part of the amount of water required for producing the polyacrylate suspension and is then homogenously incorporated into the polyacryate, which is then made into a gel.
BACKGROUND: Interleukin (IL)-17A is essential for intestinal mucosal integrity, contributing to the prevention of detrimental immunity such as infectious colitis and inflammatory bowel disease (IBD). Indeed, neutralization of IL-17A has been abandoned as a therapeutic principle in IBD because of increased disease activity. However, it is controversial whether IL-17A inhibitors increase the risk of developing colitis in patients who do not have underlying IBD. Here, we present two cases of different forms of colitis that occurred during treatment with two IL-17A inhibitors, secukinumab and ixekizumab.
CASE PRESENTATIONS: We report the case of a 35-year-old female with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome who was admitted due to severe colitis with bloody diarrhea, fever, abdominal pain and weight loss after receiving secukinumab for 3 months as well as the case of a 41-year-old male with psoriatic arthritis who presented himself to the outpatient clinic with bloody stools, abdominal pain and nausea 5 months after changing his therapy from secukinumab to ixekizumab. In both patients, treatment with IL-17A-inhibitors was stopped and tumor necrosis factor inhibitors were started. Both patients recovered, are clinically stable and show no more signs of active colitis.
CONCLUSION: The role of IL-17A inhibitors in the pathogenesis of infectious colitis and new-onset IBD is not fully understood and requires further research. Patients receiving IL-17A-inhibitor therapy should be carefully screened and notified of the possible side effects.
Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery (CD). Many vasopressors have been used for prevention of post-spinal hypotension (PSH) during CD; however, the optimum protocol for prophylaxis is not established yet. Phenylephrine (PE) is a popular vasopressor used in obstetric anesthesia; however, its use is limited by its marked cardiac depressant nature. Norepinephrine (NE) is a potent vasopressor characterized by both α adrenergic agonistic activity in addition to a weak β adrenergic agonistic activity; thus, NE is considered a vasopressor with minimal cardiac depressant effect; these pharmacological properties would make NE an attractive alternative to PE. In this study, the investigators will compare continuous variable infusion of both drugs (PE and NE) with doses of 0.75 mcg/Kg/min and 0.05 mcg/Kg/min respectively for prophylaxis against PSH during CD. We used Norepinephrine Bitartrate 8 mg ampules which contains norepinephrine base of 4 mg.
The invention comprises a sublimable, crystalline substance, m.p. 258-60 DEG , having the effect of eliminating sodium from the human or animal organism, and its preparation by separating by further distribution chromatography and/or with the aid of carboxyl reagents the amorphous fractions remaining after the almost complete separation of the known steroids from extracts of urine or suprarenal glands, and isolating the active substance in crystalline form from the biologically active fractions or the carbonyl portion.  In examples, extracts from urine or adrenal, glands are purified by distribution and adsorption chromatography, the remaining amorphous fractions subjected to paper chromatography, e.g. using formamide/benzene-chloroform or propylene glycol/toluene or benzene-ligroin-methanol-water and the product preferably further purified with Gignard T reagent to yield the carbonyl containing active substance.ALSO:Pharmaceutical compositions for restoring a disturbed sodium balance contain as active principle a sublimate, crystalline substance C21H34O3, melting-point 258-260 DEG  C. (having the effect of eliminating sodium from the human or animal organism, and isolated from urine and suprarenal glands), together with a solid or liquid carrier.  The active substance is substantially free from other active compounds occurring in urine and suprarenals, and is administered by enteral, parenteral or topical methods, e.g. in the form of aqueous or oleaginous solutions, suspensions, emulsions, implantates, tablets, dragees, salves or creams.  The compositions may include auxiliaries, e.g. preserving, wetting, stabilizing, emulsifying and buffering agents and other therapeutic compounds. Examples 4-6 detail specific compositions.
Human Adenoviruses (HAdV) are nearly ubiquitous pathogens comprising numerous sub-types that infect various tissues and organs. Among many encoded proteins that facilitate viral replication and subversion of host cellular processes, the viral E4orf1 protein has emerged as an intriguing yet under-investigated player in the complex interplay between the virus and its host. E4orf1 has gained attention as a metabolism activator and oncogenic agent, while recent research is showing that E4orf1 may play a more important role in modulating cellular pathways such as PI3K-Akt-mTOR, Ras, the immune response and further HAdV replication stages than previously anticipated. In this review, we aim to explore the structure, molecular mechanisms, and biological functions of E4orf1, shedding light on its potentially multifaceted roles during HAdV infection, including metabolic diseases and oncogenesis. Furthermore, we discuss the role of functional E4orf1 in biotechnological applications such as Adenovirus (AdV) vaccine vectors and oncolytic AdV. By dissecting the intricate relationships between HAdV types and E4orf1 proteins, this review provides valuable insights into viral pathogenesis and points to promising areas of future research.
INTRODUCTION: Premature death is a global health indicator, significantly impacted by obesity, especially in young and middle-aged population. Both body mass index (BMI) and waist circumference (WC) assess obesity, with WC specifically indicating central obesity and showing a stronger relationship with mortality. However, despite known associations between BMI and premature death, as well as the well-recognized correlation between WC and adverse health outcomes, the specific relationship between WC and premature death remains unclear. Therefore, focusing on young and middle-aged individuals, this study aimed to reliably estimate independent and combined associations between WC, BMI and premature death, thereby providing causal evidence to support strategies for obesity management.
METHODS: This study involved 49,217 subjects aged 18-50 years in the United States from 1999 to 2018 National Health and Nutrition Examination Survey (NHANES). Independent and combined associations between WC and BMI with premature death across sex and age stratum were examined by Cox regression. Survey weighting and inverse probability weighting (IPW) were further considered to control selection and confounding bias. Robustness assessment has been conducted on both NHANES and China Health and Retirement Longitudinal Study (CHARLS) data.
RESULTS: A linear and positive relationship between WC and all-cause premature death was found in both males and females, with adjusted HRs of 1.019 (95%CI = 1.004-1.034) and 1.065 (95%CI = 1.039-1.091), respectively. Nonlinear relationships were found with respect to BMI and all-cause premature death. For females aged 36-50 with a BMI below 28.6 kg/m2, the risk of premature death decreased as BMI increased, indicated by adjusted HRs of 0.856 (95%CI = 0.790-0.927). Joint analysis showed among people living with obesity, a larger WC increased premature death risk (HR = 1.924, 95%CI = 1.444-2.564).
DISCUSSION: WC and BMI exhibited prominent associations with premature death in young and middle-aged population. Maintaining an appropriate WC and BMI bears significant implications for preventing premature death.
AIM: Language difficulties in children can have enduring impacts on their academic and emotional well-being. Consequently, early identification and intervention are critical. This study aimed to investigate the impact of introducing Språkfyran, a language screening tool, on the identification and referral rates for speech and language assessment compared to the previous method.
METHODS: An observational study was conducted in Gotland, Sweden, using the medical records of 3537 children (53% boys) who were 3-4 years of age. The study period lasted between 5 January 2016 and 29 April 2022, encompassing data collection both before and after the introduction of Språkfyran.
RESULTS: Following the introduction of Språkfyran, 15% failed the screening, compared to 20% with the previous speech test. However, referrals for assessment increased significantly with Språkfyran, rising to 7% compared to 3% with the speech test.
CONCLUSION: The proportion of children who failed the Språkfyran screening was consistent with findings from previous studies. Children who failed the screening were more likely to be referred for speech and language assessment after the introduction of Språkfyran. This indicates that Språkfyran is a clinically relevant tool that promotes children's language development through increased referral rates.
A decision support engine allows defining multiple events and corresponding actions. An event could be, for example, a decision that is at variance with what the professional usually suggests, or at variance with standard practice of other professionals. Suitable action can be taken when an event occurs. Examples of suitable actions include, for example, to notify the professional, to notify the customer or patient, to notify an administrator, and to log all data related to the decision that caused the event. The decision support engine receives biometric input from one or more biometric sensors worn by the professional, and can thus log the physical state of the professional at the time the event occurs. For each event, the professional's biometric data is logged and can be analyzed to determine statistical correlations between the events corresponding to the professional and the professional's physical state.
OBJECTIVES: Addressing substance use in psychiatric care encounters significant barriers, but the emergence of specialized services offers an opportunity to advance and scale up the integration of addiction services within psychiatric settings. However, research gaps still exist in this field, particularly in understanding the substance relapse rates of people with co-occurring disorders after a psychiatric hospitalization. This study aimed to investigate and compare the relapse rates of patients under inpatient care with exclusively addiction-related issues and those with co-occurring disorders after a hospitalization in a psychiatric ward and gain insights into differences in outcomes for these two patient groups.
METHODS: This retrospective analysis examined electronic medical records of patients admitted to the Acute Psychiatry Ward of the Hospital Clinic of Barcelona with a substance use disorder diagnosis between January 2019 and February 2021. Cox regression was used to identify variables independently associated with the first relapse episode.
RESULTS: From a total of 318 admissions (79.2% with psychiatric comorbidity), 76.1% relapsed during the study follow-up, with a median survival time of 54 days. Younger age, female gender, voluntary admission, and outpatient follow-up were independently associated with relapse. The presence of a co-occurring disorder was not associated with relapse.
CONCLUSION: This study highlights the need for interventions aimed at improving post-discharge abstinence rates for addiction-related hospitalizations. It also challenges the notion that co-occurring disorders automatically imply a worsened prognosis and emphasizes the importance of addressing addiction and psychiatric comorbidity in a comprehensive, integrated, and specialized manner.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic having a massage function and a cleansing function which can independently exist, respectively.  <P>SOLUTION: This oil-in-water emulsion type cosmetic containing a fatty acid soap is characterized by containing at least two polyglycerol monofatty acid esters. The cosmetic preferably contains a diglycerol monofatty acid ester and a decaglycerol monofatty acid ester as the at least two polyglycerol monofatty acid esters. The cosmetic preferably contains diglycerol monolaurate as the diglycerol monofatty acid ester. The cosmetic preferably contains decaglycerol monooleate as the decaglycerol monofatty acid ester.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
In closed kinetic chain exercises extremities are fixed and weight bearing is done. Subjects performed group of exercises, 3sets with 10 repetitions for each exercise after warm up and stretching exercises. The closed kinetic chain exercise program consisted of 1) seated leg presses, 2) one-third knee bends on one leg and on both legs, 3) stationary bicycling, 4) rowing-machine exercises, 5) step-up and step-down exercises. Each exercise in the closed kinetic chain protocol was performed dynamically with a 3-second rest between repetitions.
Compositions and methods for suppressing cancer cell growth by a synthetic chromatin effector. For example, a synthetic histone-binding regulator protein, polycomb-based transcription factor (PcTF), is utilized to activate suppression of cancer cell growth. Accordingly, an exemplary method disclosed herein may directly target a generally conserved feature, such as elevated trimethyl-lysine 27 on histone H3 (H3K27me3), with PcTF. In addition, a set of 19 PcTF-upregulated genes, or PUGs, that were consistent across three distinct breast cancer cell lines, were identified. These genes are associated with the interferon response pathway. The results demonstrate for the first time a chromatin-mediated interferon-related transcriptional response driven by an engineered fusion protein that physically links repressive histone marks with active transcription.
Angiotensin receptor neprilysin inhibitor Sacubitril / Valsartan: The treatment period begins on day 1 with initial dosing of sacubitril/valsartan, followed by uptitration every 2 to 4 weeks to the target dose of 97/103 mg twice daily. 3 doses of sacubitril/valsartan available throughout the study are 24/26 mg, 49/51 mg, and 97/103 mg, each taken by mouth twice daily. If the patient discontinues the study medication, the patient is advised to return to the clinic for an end-of-study visit. Patients undergo treatment for 4 months.
Hereditary Breast and Ovarian Cancer (HBOC) is a genetic condition associated with increased risk of cancers. The past decade has brought about significant changes to hereditary breast and ovarian cancer (HBOC) diagnostic testing with new treatments, testing methods and strategies, and evolving information on genetic associations. These best practice guidelines have been produced to assist clinical laboratories in effectively addressing the complexities of HBOC testing, while taking into account advancements since the last guidelines were published in 2007. These guidelines summarise cancer risk data from recent studies for the most commonly tested high and moderate risk HBOC genes for laboratories to refer to as a guide. Furthermore, recommendations are provided for somatic and germline testing services with regards to clinical referral, laboratory analyses, variant interpretation, and reporting. The guidelines present recommendations where 'must' is assigned to advocate that the recommendation is essential; and 'should' is assigned to advocate that the recommendation is highly advised but may not be universally applicable. Recommendations are presented in the form of shaded italicised statements throughout the document, and in the form of a table in supplementary materials (Table S4). Finally, for the purposes of encouraging standardisation and aiding implementation of recommendations, example report wording covering the essential points to be included is provided for the most common HBOC referral and reporting scenarios. These guidelines are aimed primarily at genomic scientists working in diagnostic testing laboratories.
Subjects in this group will be submitted to the WBV for 5 to 20 minutes, 2 or 3 times a week while 12 months. The training included light squats at 35-50 Hz and ended up by stretching and relaxation exercises.
In this group, serratus anterior plane block (SAPB) was performed before extubation with injection of 30 ml of 0.25% bupivacaine hydrochloride followed by 0.1ml/kg/hr of 0.12% bupivacaine hydrochloride. In addition to SAPB, intravenous patient-controlled-analgesia morphine was used. Morphine solution was prepared at a concentration of 0.5 mg/mL with the device programmed to 2 mg of bolus dose and 10 min of locking time.
BACKGROUND: Chronic Low Back Pain (cLBP) poses a significant health challenge, leading to functional disability and reduced quality of life. Osteopathic Manipulative Treatment (OMT) is emerging as a therapeutic option for cLBP, but the brain mechanisms underlying its analgesic effect remain unclear.
MATERIALS AND METHODS: Thirty cLBP patients were randomly exposed to either four weekly sessions of OMT (N=16) or Sham treatment (N=14). Resting-state Magnetic Resonance Imaging (rs-MRI) scans and pain perception questionnaires were collected before and after treatment. A voxel-wise, rs-fMRI data-driven analysis was conducted to identify changes in the intrinsic functional connectivity across the whole brain that were associated with the OMT. Spearman's correlations were used to test for the association between changes in intrinsic connectivity and individual reports of pain perception.
RESULTS: Compared to the Sham group, participants who received OMT showed significant alterations in the functional connectivity of several regions belonging to the pain matrix. Specifically, OMT was associated with decreased connectivity of a parietal cluster that includes the somatosensory cortex and an increase of connectivity of the right anterior insula and ventral and dorsal anterolateral prefrontal areas. Crucially, the change in connectivity strength observed in the ventral anterolateral prefrontal cortex, a putative region of the affective-reappraisive layer of the pain matrix, correlates with the reduction in pain perception caused by the OMT.
CONCLUSIONS: This study offers insights into the brain mechanisms underlying the analgesic effect of OMT. Our findings support a link between OMT-driven functional cortical architecture alterations and improved clinical outcomes.