anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
On their scheduled day, participants will be instructed to come to the clinic after an overnight fast of a minimum of 8 hours (subjects can drink water). The participants will be asked to refrain from drinking alcohol for a period of 24 hours before the study days and to not perform strenuous exercise for a period of 48 hours before the study days. The participants will be directed to avoid alcohol and strenuous exercise for the duration of the study.

On days 1 and 3 of the study period, participants will be checked into the clinic. A physical examination, including height, weight and waist circumference, and finger-stick glucose will be performed. A 75-g OGTT will be performed with venous samples for measurement of glucose, insulin and C-peptide levels obtained at 0, 30 and 60 minutes starting immediately after the ingestion of the 75 g glucose solution. After samples are collected on day 1, participants will be administered their first dose of steroid, prednisone 40 mg, and be given a packet of two additional doses for the rest of the study period. The investigators may only give 1 additional dose to them and have the participants take the last dose in clinic on day 3 two hours before the OGTT. Subjects will take prednisone 40 mg once daily for three days to be consumed around 8:00am on days 2 and 3. This dose was chosen as a typical high-dose glucocorticoid regimen. On the third day, the participants will again visit the clinic after an overnight fast of a minimum 8 hours and undergo a physical examination and OGTT just as on day 1.

Participants will be instructed to check pre-prandial (before breakfast, lunch and dinner), and bed time (around 10:00 pm) blood glucose (BG) levels and to record all values for a total of five days (three days while on prednisone and for two days after the second study visit). A member of the study staff will call each participant daily around 7:00 pm to obtain BG values. Compliance with the study protocol will be assessed at this time as well. Any subject not compliant with study medications will be excluded from the study.
Active rTMS will be administered with a MagPro X100 stimulator (MagVenture, Denmark), using a 70 mm figure-of-eight liquid cooled coil capable of doing active or sham stimulation (e.g. the Cool B70 coil or the Cool B65 A/P coil). Active rTMS will be delivered at 80% of a patient's active motor threshold. rTMS will be administered in an excitatory iTBS pattern. Stimulation parameters will remain well within established safety guidelines (Rossi et al. 2009).
OBJECTIVES: To observe the functional differences in the key brain areas in patients with different levels of consciousness after severe brain injury, and provide reference for confirming the objective diagnosis indicators for prolonged disorders of consciousness (pDoCs).
METHODS: This prospective study enrolled patients with pDoCs hospitalized in the department of rehabilitation medicine of our Hospital. Levels of consciousness and clinical outcomes were assessed according to diagnostic criteria and behavioral scales. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) of 30 patients with different levels of consciousness was performed. The patients were grouped as conscious or unconscious according to whether they regained consciousness during the 12-month follow-up.
RESULTS: Thirty patients were enrolled, including eight with unresponsive wakefulness syndrome/vegetative state, eight with minimally conscious state, six with emergence from the minimally conscious state, and eight with a locked-in syndrome. There were 19 and 11 patients in the conscious and unconscious groups. Compared with the unconscious group, the left basal nucleus was activated in the conscious group, and there were significant differences in white matter fiber bundles. Correlations were observed between the regional homogeneity (ReHo) value of the cerebellum and the Glasgow coma scale score (r = 0.387, P = 0.038) and between the ReHo value of the left temporal and the coma recovery scale-revised score (r = 0.394, P = 0.035).
CONCLUSIONS: The left insula and cerebellum might be important for regaining consciousness. The brain function activity and structural remodeling of the key brain regions and the activation level of the cerebellum are correlated with clinical behaviors and have potential application value for the prognosis prediction of pDoCs patients.
A patch comprising a layer of material (4) that reflects the infra red radiation generated by the human body, a matrix (3) of a self-adhesive material which is of an acrylic or vinyl polymer in which the adhesive properties increase with temperature in the range 20 - 40  deg C, and within this matrix at least one active material having an effect on the skin. The matrix (3) is preferably joined to a support sheet (2), the reflecting layer (4) being attached to the other side of the support, preferably formed by metallization of this support, though where the support is a metal, especially aluminum, a separate reflecting layer is not necessary.  The reflecting layer may be either smooth or undulating.  The matrix (3) is preferably protected on the surface that will contact the skin by means of a removable protective sheet, (5a) and (5b).   If desired the matrix may further contain, at least partially, a permeable structure (6) within its mass to modify the adhesive power of the matrix.  The matrix (3) of one or more acrylic or vinyl polymers has an adherence (measured parallel to the contacting surface), of 50-800 g/cm<2>. Its thickness is preferably in the range 0.1 - 3 mm.
The method for treating onychomycosis involving more than three nail plates or more than 50 % of each nail plate comprises the systemic and topical antimycotics. The treatment starts in 4 weeks preceding the systemic antimycotics. The pathogenetic drugs are also prescribed. Xanthinol nicotinate is taken per os at a dose of 150 mg thrice a day, Biotin is taken at a dose of 5 mg once a day, and Heparsil – at a dose of 70 mg thrice a day for 90 days. Since the 5th week, Lamifen is provided per os at a dose of 250 mg once a day until the complete recovery of the nail plates. The paste is administered onto the nail plates throughout the course of the treatment.
This study aimed to investigate clinical features, influencing factors and neurobiochemical mechanisms of olfactory dysfunction (OD) in Parkinson disease (PD). Total 39 patients were divided into the PD with OD (PD-OD) and PD with no OD (PD-nOD) groups according to overall olfactory function, including threshold, discrimination and identification, assessed by Sniffin' Sticks test. Motor function and non-motor symptoms were rated by multiple scales. Dopamine, acetylcholine, norepinephrine and 5-hydroxytryptamine levels in cerebrospinal fluid (CSF) were measured. We found that the PD-OD group showed significantly lower score of Montreal Cognitive Assessment Scale, higher scores of rapid eye movement sleep behavior disorder (RBD) Screening Questionnaire and Epworth Sleepiness Scale than the PD-nOD group (p < 0.05). RBD Screening Questionnaire score was independently associated with the scores of overall olfactory function and discrimination (p < 0.05). Dopamine and acetylcholine levels in CSF from the PD-OD group was significantly lower than that from the PD-nOD group (p < 0.05). Dopamine and acetylcholine levels in CSF were significantly and positively correlated with the scores of overall olfactory function, threshold, discrimination and identification in PD patients (p < 0.05). RBD Screening Questionnaire score was significantly and negatively correlated with acetylcholine level in CSF in PD patients with poor olfactory detection (p < 0.05). This investigation reveals that PD-OD is associated with cognitive impairment, probable RBD and excessive daytime sleepiness. PD-OD is correlated with the decreased levels of dopamine and acetylcholine in CSF. RBD is an independent influencing factor of overall olfactory function and discrimination, and the decreased acetylcholine level in CSF may be the common neurobiochemical basis of RBD and OD in PD patients.
Approximately 60-75% of children with severe/profound sensorineural hearing loss (SNHL) also have vestibular hypofunction (VH), resulting in delayed gross motor development, poor postural control, and gaze instability. Although clinical practice guidelines provide recommendations for adults with VH, no statements exist for children due to a paucity of high- level studies. The long-term objective of this proposal is to assess feasibility of a home-based vestibular balance therapy (VBT) program for children so that a larger well-powered controlled study can be designed. The specific aims are to assess the intervention's feasibility (Aim 1), estimate its preliminary impact on functional outcomes (Aim 2), and assess participant engagement (secondary Aim). To accomplish this, we will use a prospective single arm feasibility design. We will enroll 15 children with SNHL, aged 6-12 years; 12 with confirmed VH for the VBT, and 3 with normal vestibular function to test the sham intervention. All children will be tested on the functional outcomes: computerized dynamic visual acuity, modified functional gait assessment, and sensory organization test at baseline, 4, and 8 weeks. A physical therapist (PT) will train children/caregivers in the 8-week structured VBT home program consisting of 4 categories of exercises (Times 1 viewing, gaze shifting, static and dynamic balance) done 5 times/week, 5 minutes/exercise. The PT will meet weekly with the child/caregiver in person to systematically progress the exercises. The children in the sham intervention (10 minutes of reading, 10 minutes of play) will also receive weekly meetings with the PT to control for attention bias. To assess Aim 1 (Feasibility) metrics will include process (e.g., recruitment rates), resources (e.g., communication needs), management (e.g., data collection/entry), experience (e.g., barriers). To assess Aim 2 (impact) we will analyze within group changes and effect sizes to design the larger study.
A polymer having a recurring structural unit of formula <FORM:1102237/C3/1> wherein R1 and R3, which may be the same or different, each represent hydrogen or C1- 4 alkyl or hydroxyalkyl, R2 is hydrogen or methyl, q is 2-6, p is 0 or 1, R1 and R11, which may be the same or different, each represent hydrogen, C1- 4 alkyl, phenyl or C1- 4 alkoxy and R111 represents hydrogen, -O-CO-CH3, -CN or -COOCH3, may be obtained by condensing a starting polymer having a recurring structural unit of formula <FORM:1102237/C3/2> in solution with a mercapto-amide amine of formula:  <FORM:1102237/C3/3> The polymers preferably have a molecular weight of at most 6000 and are soluble in aqueous alkaline media.  The quantity of mercapto-amide amine starting material is suitably employed in stoichiometric proportion to the anhydride function of starting polymer and the carboxylic acid group formed during the condensation may be neutralized with a base. The above starting polymers are suitably (a) copolymers of maleic anhydride and vinyl-methyl ether, vinylethyl ether or divinylphenyl ether; (b) copolymers of styrene and maleic anhydride; (c) copolymers of ethylene and maleic anhydride; (d) a copolymer of vinyl acetate and maleic anhydride; (e) a copolymer of maleic anhydride and methyl acrylate, methyl methacrylate or acrylonitrile.  The polymer may be compounded with water, urea and ammonia.ALSO:Mercapto-amide amines of the formula <FORM:1102237/C2/1> where R1 and R3, which may be the same or different, each represent a hydrogen atom, C1- 4 alkyl or C1- 4 hydroxy alkyl, R2 is hydrogen or methyl, p is 0 or 1 and q is 2-6, may be obtained condensing an alkyl (C1- 4) ester of a mercapto carboxylic acid of the formula <FORM:1102237/C2/2> in solution with an aliphatic diamine of the formula R1-NH-(CH2)q-NH-R3 The reaction may be effected at ambient temperatures or under reflux, suitable mercaptocarboxylic acids whose esters may be used in the process being thioglycolic, thiolactic and b -mercaptopropionic acids, and suitable diamines are, for example, ethylenediamine, trimethylenediamine and hydroxyethylethylene diamine.ALSO:A hair-treatment composition for use in the waving of hair comprises an alkaline aqueous solution of a polymer having a recurring structural unit of the formula:  <FORM:1102237/D1-D2/1> where R1 and R3, which may be the same or different, represent hydrogen or C1-4 alkyl or hydroxyalkyl, R2 is hydrogen or methyl, q is 2-6, p is 0 or 1, R\sv and R\yF, which may be the same or different represent hydrogen, C1-4 alkyl, phenyl or C1-4 alkoxy and R\yG represents hydrogen or the radicals -O-CO-CH3 -CN or -COOCH3. The polymers suitably have a molecular weight of at most 6000 and the p  hair may be impregnated with said composition, constrained to the desired shape and any undesired excess of said composition removed, after which the hair may be rinsed and treated with a hair-treatment oxidising agent.  The compositions may also be employed to impregnate keratinic textile fibres such as wool, which may thereafter be dyed with direct dyes.
Cardiac arrest (CA) management remains challenging. As fewer than 20% of patients survive to discharge, early prognostication of functional outcome needs accurate prediction.Survivors outcome depends on initial CA conditions (cause, duration and severity of ischemic injury) that may lead to the post-cardiac arrest syndrome, associated with high mortality. Hypoxic-ischemic encephalopathy is the second cause of poor outcome after CA. Indeed, most survivors remain comatose or in a vegetative state leading to decisions to withdraw life support. Thus, the American Academy of Neurology had proposed a decision algorithm for use in prognostication of comatose survivors published in 2006.Before the widespread use of therapeutic hypothermia (TH), predictor factors of neurological outcome were: serum neuron-specific enolase (NSE), N20 somatosensory-evoked potentials (SSEP), status epilepticus, pupil and corneal reflexes and Glasgow coma score motor response (GCS-M). Therapeutic hypothermia is recommended in the management of CA.It has been associated with improved outcome after ventricular fibrillation out-of-hospital cardiac arrest (OHCA). However, TH may interfere with clinical examination and electrophysiological predictors (EEG, SSEP) making prognostication of functional outcome hardiest.The use of sedative drugs and muscle paralysis during TH is another cause of delayed neurological assessment and prognostication.The NSE cutoff values to predict poor neurological outcome are not well defined and can be influenced by TH either.The present study aims at identifying clinical, electrophysiological and biological prognostication predictors of 6-month neurological outcome in survivors at day 3 after CA treated by TH. Neurological functional status was assessed using the 5-item scale Cerebral Performance Category (CPC). Neurological status was retrospectively assessed at 6 months: CPC of 1 or 2 was defined as good neurological outcome and CPC of 3 to 5 were defined as poor neurological outcome. Deaths in the first 3 days and decisions to withdraw or to withhold life support were also collected. The following prognostication factors were tested: neurological examination at day 3 and 7 including corneal and pupillary reflexes, GCS-M, status epilepticus, electro-encephalogram (EEG), SSEPs and NSE levels between day 2 and day 3.
Better communication with older people requires not only improving speech intelligibility but also understanding how well emotions can be conveyed and the effect of age and hearing loss (HL) on emotion perception. In this paper, emotion discrimination experiments were conducted using a vocal morphing method and an HL simulator in young normal hearing (YNH) and older participants. Speech sounds were morphed to represent intermediate emotions between all combinations of happiness, sadness, and anger. Discrimination performance was compared when the YNH listened to normal sounds, when the same YNH listened to HL simulated sounds, and when older people listened to the same normal sounds. The results showed that there was no significant difference between discrimination with and without HL simulation, suggesting that peripheral HL may not affect emotion perception. The discrimination performance of the older participants was significantly worse only for the anger-happiness pair than for the other emotion pairs and for the YNH. It was also found that the difficulty increases with age, not just with hearing level.
<P>PROBLEM TO BE SOLVED: To provide a medical intelligent server architecture for computer-assisted detection, in which extension is possible to cope with an ever increasing number of patients, and service detection can be easily varied or added based on various modalities.  <P>SOLUTION: The architecture comprises dedicated server configuration, providing disease detection service when a set of medical images are provided. The architecture can be combined with an existing medical information system. The architecture for computer-assisted detection is adaptable to variation required by the computer-assisted detection service, and is easily extensible to include new or varied detection service. It is thus extensible to adapt to images from an ever increasing number of patients of various types.  <P>COPYRIGHT: (C)2008,JPO&INPIT
BACKGROUND: Severe obesity impairs renal function and outcomes in kidney transplant recipients. Bariatric surgery benefits those unresponsive to medical treatments. Limited case reports exist on its efficacy and long-term prognosis for transplant candidates. Thus, this study aims to present a case in which laparoscopic sleeve gastrectomy was safely performed on a patient with severe obesity awaiting kidney transplantation.
CASE PRESENTATION: This study included a dialysis patient with a body mass index of 47 kg/m2. Living-donor kidney transplantation using his younger sister as a donor was considered, but it was determined that the risk of complications during and after surgery was high. Medical treatment was first performed, but the obesity did not improve; therefore, a laparoscopic sleeve gastrectomy was performed. Although postoperative bleeding occurred, the patient was discharged from the hospital on the 14th postoperative day. Subsequently, his weight steadily decreased, and living-donor kidney transplantation was performed 13 months after laparoscopic sleeve gastrectomy was performed. Furthermore, the patient's progress after kidney transplantation was good, and he was freed from hemodialysis.
CONCLUSION: Improving severe obesity before kidney transplantation is effective in improving prognosis, and bariatric surgery should be considered when medical treatment is ineffective. Future research are needed to determine the optimal time between the performance of this procedure and kidney transplantation, as well as the long-term prognosis after kidney transplantation.
AIM: This study aimed to explore the value of ultrasound (US) images in chronic kidney disease (CKD) screening by constructing a CKD screening model based on grey-scale US images.
METHODS: According to the CKD diagnostic criteria, 1049 patients from Tongde Hospital of Zhejiang Province were retrospectively enrolled in the study. A total of 4365 renal US images were collected from these patients. Convolutional neural networks were used for feature extractions and a screening model was constructed by fusing ResNet34 and texture features to identify CKD and its stage. A comparative analysis was performed to compare the diagnosis results of the model with physicians.
RESULTS: When diagnosing CKD or non-CKD, the receiver operating characteristic curve (AUC) of our model was 0.918 and that of the senior physician group was 0.869 (p < .05). For the diagnosis of CKD stage, the AUC of our model for CKD G1-G3 was 0.781, 0.880, and 0.905, respectively, while the AUC of the senior physician group for CKD G1-G3 was 0.506, 0.586, and 0.796, respectively; all differences were statistically significant (p < .05). The diagnostic efficiency of our model for CKD G4 and G5 reached the level of the senior physicians group. Specifically, the AUC of our model for CKD G4-G5 was 0.867 and 0.931, respectively, while the AUC of the senior physician group for CKD G4-G5 was 0.838 and 0.963, respectively (all p > .05).
CONCLUSIONS: Our deep learning radiomics model is more effective than senior physicians in the diagnosis of early CKD.
Considerably less attention has been paid to Plasmodium vivax epidemiology than Plasmodium falciparum. In areas of relatively low unstable transmission, which comprise the majority of P.vivax affected areas, vivax malaria is predominantly a disease of children (Luxemburger et al 1999). Chloroquine has long been the standard treatment for vivax malaria. Primaquine is recommended for radical cure of vivax malaria, but is difficult to administer due to dosing duration and side effects.

This study aims to characterize the epidemiologic history comparing the efficacy of 3 antimalarial regimens (chloroquine, artesunate, and chloroquine/primaquine) for plasmodium vivax in western Thailand. Chloroquine is currently the standard of treatment for Plasmodium vivax. Due to the long half-life or chloroquine, the first relapse of vivax malaria may be delayed. In contrast, artesunate has a very short half-life, thus, having no impact on first relapse. It is not known whether chloroquine reduces the overall number of relapses, or only delays the first relapse. There are many important questions about the biology of vivax malaria of relevance to treatment that remain unanswered. For example is the number of relapses per infection (i.e. per successful inoculation) predetermined or adaptive? If it is predetermined then suppression of the first relapse (as with chloroquine, mefloquine or piperaquine) will reduce the total number of relapses and this is a clear benefit. If it is adaptive then these drugs will simply delay the relapses and there is less clear benefit. These various uncertainties illustrate the importance of detailed comparative longitudinal evaluations. In order to characterize the biology of vivax malaria, it will be necessary to compare regimens with and without primaquine. Because of the challenges that face primaquine prescription (side effects, toxicity in G6PD deficient patients and duration of treatment), it is not commonly deployed along the Thai Burma border. In effect, we will be comparing usual practice (non primaquine regimens) with the recommended WHO and Thai MOPH practice (use of primaquine for 14 days). The information we will gather is crucial to the understanding of chloroquine and its effect on the vivax parasite. This will lead to future studies and invariably change the way we treat vivax malaria.
This 2 phase study first determines the prevalence of acute bilirubin encephalopathy (ABE) among newborns admitted for treatment of jaundice at 5 regional centers in Nigeria and identifies social/behavioral/medical factors associated with ABE. Information gained in phase 1 identified high risk sub-populations and guided selection of instructional materials for phase 2. Core data sheets submitted monthly by participating centers included clinical data, demographic information, number of antenatal clinic visits, birth place (hospital, clinic, home) and attendant, distance from care centers and reasons for delay, if any, in seeking care. Receipt of jaundice instruction by mothers is self-reported. Statistical analysis includes Chi square and logistic regression analysis of risk factors. Sample size: 1,000 subjects in each phase are required to demonstrate a 20% decrease in disease prevalence (baseline ABE incidence anticipated to be 15% of jaundiced babies) at 95% confidence level.