anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Bilateral ultrasound guided erector spinae plane catheter placement for the administration of lidocaine. Dose will be 2 mg/kg ideal body weight. Bolus will be divided equally between the two ESP catheters. This is followed by lidocaine infusion via ESP catheter at 2 mg/kg/hr for 48 hours after catheter placement.
Cardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic predisposition and corresponding endophenotypes contributing to SUD remain incompletely understood. In this study, we aimed to investigate the involvement of Coenzyme Q (CoQ) deficiency in SUD. First, we re-analyzed the exome sequencing data of 45 SUD and 151 sudden infant death syndrome (SIDS) cases from our previous studies, focusing on previously overlooked genetic variants in 44 human CoQ deficiency-related genes. A considerable proportion of the SUD (38%) and SIDS (37%) cases were found to harbor rare variants with likely functional effects. Subsequent burden testing, including all rare exonic and untranslated region variants identified in our case cohorts, further confirmed the existence of significant genetic burden. Based on the genetic findings, the influence of CoQ deficiency on electrophysiological and morphological properties was further examined in a mouse model. A significantly prolonged PR interval and an increased occurrence of atrioventricular block were observed in the 4-nitrobenzoate induced CoQ deficiency mouse group, suggesting that CoQ deficiency may predispose individuals to sudden death through an increased risk of cardiac arrhythmia. Overall, our findings suggest that CoQ deficiency-related genes should also be considered in the molecular autopsy of SUD.
FIELD: medicine, phytotherapy, pharmacy. SUBSTANCE: preparation shows anticoagulative, antioxidative, actoprotective, neuroprotective, analgetic, capillary-strengthening, anti-alterative, anti-exudative, antiproliferative, wound-healing and immunomodulating effect. Preparation is based on medicinal sweet clover herb extractive substances and comprises the following components, wt.-%: extractive substances, 0.1-40; 20-95% ethyl alcohol or purified water, the balance. Method for preparing involves extraction of vegetable raw by fractional maceration with purified water at temperature 80-90 C or percolation with ethyl alcohol of different concentration for 1-168 h in the ratio raw : extractant = 1 : (5-100) followed by condensing alcoholic or aqueous extraction of extractive substances as coumarins and flavonoids and their drying up to preparing dry extract. Invention provides maximal extraction of extractive substances and their retention for a long time also. EFFECT: improved preparing method, valuable medicinal properties of preparation. 4 cl, 2 tbl, 6 ex
The present disclosure provides an "automated triage nurse system in a vehicle. Exemplary embodiments described in this disclosure generally relate to automated triage nurse systems in vehicles. In an exemplary scenario, the system issues a set of questions to assess the severity of a medical emergency associated with an occupant of the vehicle. The problem may be issued by an audio system in the vehicle and the medical emergency may be caused by a vehicle accident or may be a medical trauma inflicted on the occupant. The system provides a medical recommendation to the occupant if the occupant provides a response indicating to the system that it is not necessary to summon the first responder. The medical advice may be first aid instructions. On the other hand, if the occupant of the vehicle does not provide a response or provides a response indicating a serious medical problem, the system may contact a first responder located in a medical facility.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, and the prognosis for its recurrence after surgery is very poor. Here, we report a case of metachronous oligo-hepatic and peritoneal metastases in a patient who survived without recurrence for 3 years after conversion surgery combined with perioperative sequential chemotherapy using gemcitabine plus nab-paclitaxel (GnP) and modified FOLFIRINOX (mFOLFIRINOX). The patient was a 70-year-old man with pancreatic ductal carcinoma, classified as cT3N0M0, cStage IIA, who underwent a distal pancreatosplenectomy. At 1 year and 4 months later, two liver metastases and one peritoneal metastasis were detected. A systemic 9-month course of chemotherapy was administered with GnP and mFOLFIRINOX as the first- and second-line chemotherapeutic agents, respectively. The two liver metastases were judged as showing a partial response, but one dissemination was considered stable disease. After receiving informed consent from the patient, we performed resection of the disseminated tumor and lateral segmentectomy of the liver. Adjuvant chemotherapy using mFOLFIRINOX and GnP was administered for 10 months. The patient has now been alive for 5 years and 6 months after the initial pancreatosplenectomy, and 3 years and 3 months after the conversion surgery, without subsequent tumor recurrence. Thus, a multidisciplinary treatment approach including surgery and perioperative sequential chemotherapy using GnP and mFOLFIRINOX may be beneficial for treating metachronous oligo-hepatic and peritoneal metastases, depending on the patient's condition.
OBJECTIVE: As an indolent malignant tumor, the long-term management of low-grade endometrial stromal sarcoma (LGESS) patients required awareness, especially the management of recurrences. Unfortunately, few studies focused on the treatment of recurrent LGESS. Our study aimed to investigate the prognostic factors and the value of recurrent surgery on recurrent LGESS.
METHODS: This retrospective study consecutively recruited patients with pathologically diagnosed recurrent LGESS at our center from April 1, 2004 to April 1, 2020.
RESULTS: After a median follow-up of 137.0 months (95% confidence interval=85.4-188.6), the 5-year cumulative survival rate of the cohort of 38 patients with recurrent LGESS was 71.1%. The median overall survival (OS) and post-recurrence survival (PRS) was 156 and 89.0 months. Survival analysis showed that patients with younger age, positive estrogen receptor (ER) and optimal abdominopelvic debulking in the first recurrent surgery had better prognosis (p<0.05). Multivariate analysis showed that optimal abdominopelvic debulking in the first recurrent surgery was the only independent prognostic factor for OS and PRS (OS=216.0/35.0 months, hazard ratio [HR]=5.319, p=0.034; PRS=not reached/4.0 months, HR=10.900, p=0.006). There was no significant difference in OS and PRS between patients recurred only once and those recurred at least twice (p>0.05).
CONCLUSIONS: The prognosis of recurrent LGESS was favorable. Optimal debulking of no residual tumor in abdominal and pelvic cavity should be the first choice of treatment for recurrent patients, while preservation of ovary or fertility should not be recommended.
Usual care (TAU) for adults with SMI in Massachusetts consists of rehabilitation services publicly funded by the state and traditional fee for service outpatient medical and psychiatric care. Importantly, medical care is not programmatically integrated with the psychiatric rehabilitation services. Participants in this arm will receive no other study-related intervention.Cohort 1 (AD-eligible) comprised participants seen in primary care clinics serving ≥3 enrolled participants.
The invention discloses an application of dimethyl fumarate in preparing a medicament for treating periapical periodontitis. Use of dimethyl fumarate for the treatment of disease by placing it in the root canal of an infection. Dimethyl fumarate can inhibit non-classical focal death of dental pulp cells and periodontal ligament cells caused by transfection of lipopolysaccharide. Dimethyl fumarate can inhibit pro-inflammatory polarization of macrophages by acting on glycolysis on the one hand, and can inhibit pyrosis of macrophages and fibroblasts on the other hand, reducing the release of inflammatory factors. Dimethyl fumarate can also regulate bone metabolism. Chronic periapical periodontitis usually results in absorption of periapical alveolar bone, and application of dimethyl fumarate may slow bone destruction of periapical periodontitis, thereby achieving the effect of treating diseases. Therefore, the dimethyl fumarate can be used as a medicine for the inter-diagnosis sealing medicine for treating the suffering teeth of root canal treatment, and plays roles of regulating immunity and slowing down the bone destruction of periapical periodontitis.
Fosinopril sodium tablets are indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Fosinopril sodium tablets are indicated in the management of heart failure as adjunctive therapy when added to conventional therapy including diuretics with or without digitalis (see DOSAGE AND ADMINISTRATION).

In using fosinopril sodium, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that fosinopril sodium does not have a similar risk (see WARNINGS).

In considering use of fosinopril sodium, it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients (see WARNINGS: Head and Neck Angioedema and Intestinal Angioedema).
The present invention relates to the use of topical interferon-.alpha. for the treatment of various forms of fibrosis in and around the eye arising from various ophthalmic diseases and procedures.  Specifically the invention relates to alleviation of corneal scarring after laser photoablative refractive keratectomy (PRK). It aslo relates to the alleviation of posterior (lens) capsular opacification after extracapsular cataract surgery with lens implant;  the alleviation of wound scarring following glaucoma filtration surgery. Interferon-.alpha. may also be used to coat the lens implant prior to or during implantation. It may also possibly be injected into the eye during eye surgery for inhibiting posterior capsule opacification after cataract surgery and in addition may be injected into the vitreous body to prevent retinal fibrosis and proliferative vitreo-retinopathy, and injected subconjunctivally to inhibit fibrosis and scarring following glaucoma filtration surgery.
BACKGROUND: As populations live longer, there is a progressive increase in chronic degenerative diseases, particularly those related to the musculoskeletal system. Sarcopenia is characterized by loss of skeletal muscle mass, muscle strength, and loss of physical function. It is a common disease in older adults associated with various adverse health outcomes. There is a lack of bioindicators to screen for sarcopenia. Albumin and lymphocyte counts are commonly used to assess the degree of malnutrition, and blood routine, lipids, and thyroid function are relatively easy to obtain as part of a routine physical examination. Therefore, finding blood markers that can screen for sarcopenia is essential. Our primary aim was to explore whether the bioindicators of body composition, lymphocytes, albumin, lipids, and thyroid hormones are associated with sarcopenia, and a secondary aim was to investigate changes in these indicators after an intensive lifestyle intervention preliminarily.
METHODS: 60 subjects were selected from Runda and Bailian community health centers in Suzhou, China. They underwent body composition analysis and tested lymphocyte, albumin, lipid, and thyroid hormone levels. The 30 sarcopenia subjects underwent a 3-month intensive lifestyle intervention program. At the end of the intervention, we rechecked the bioindicators. Statistical analyses were performed in IBM SPSS v26.0.
RESULTS: The blood indices of sarcopenia subjects were generally lower in albumin, non-high-density lipoprotein cholesterol (non-HDL-C), and free triiodothyronine (FT3). Body mass index (BMI)(r = 0.6266, p < 0.0001), fat-free mass (r = 0.8110, p < 0.0001), basal metabolism (r = 0.7782, p < 0.0001), and fat mass (r = 0.3916, p = 0.0020) were positively correlated with appendicular skeletal muscle index (ASMI). Higher BMI and FT3 were associated with lower odds of sarcopenia, while higher fat mass was associated with higher odds of sarcopenia. After a 3-month intensive intervention, sarcopenia subjects had a significant increase in BMI, ASMI, lymphocyte, and albumin levels, and an increase in FT3, but with a non-significant difference (p = 0.342).
CONCLUSIONS: Low BMI, FT3, and high fat mass were associated with sarcopenia. Intensive lifestyle intervention can significantly improve ASMI, BMI, lymphocytes, albumin, and FT3 in sarcopenia subjects, which is favorable for delaying the progression of sarcopenia.
TRIAL REGISTRATION: This study was retrospectively registered on ClinicalTrials.gov, registration number NCT06128577, date of registration: 07/11/2023.
The colonoscope will be passed transanally into the left colon. It will be identified the endoscopic transilluminating point to the abdominal wall. Percutaneous anterior colopexy will be performed, using a gastropexy device that is included in the percutaneous endoscopic gastrostomy (PEG) kit . This technique involves the placement of a threaded nylon fastener into the colon through a needle.

The endoscope will be manipulated until the light approaches the premarked site. A small skin disc will then be removed at this location and a loop colostomy will be made. The colonoscope will also be used as a guide to identify the proximal and distal limbs of the loop colostomy.
Fat-soluble drugs refer to drugs that are insoluble in water but soluble in fats and organic solvents such as carbon tetrachloride, glycerol, oils and other organic solvents. They can fuse with the phospholipid bilayer of cell membranes, are easily absorbed, and are easier to pass compared to water-soluble drugs. It is metabolized by the liver, and the metabolites are excreted by the kidneys, so it has a high clinical use rate. However, in recent years, due to the improper use of fat-soluble drugs by patients, fat-soluble benzodiazepines sedative and hypnotic drugs, fat-soluble calcium channel blockers and β-blocker drugs, fat-soluble tricyclic drugs have often occurred. Poisoning such as antidepressants poses a serious threat to the lives of patients.In addition, organophosphorus pesticides (fat-soluble) have a high usage rate in China. Severe organophosphorus poisoning can cause multiple organ damages, and delays in treatment can cause disability or even death. Clinical treatment is mainly based on routine gastric lavage and oxygen inhalation. Treatment is the mainstay, combined with medical drugs, hemodialysis, hemoperfusion, etc., and has achieved certain curative effects, but the mortality rate is still high, so it is of great significance to explore safer and more effective treatment methods.Intravenous lipid emulsion (ILE) was originally used to treat overdose of local anesthetics such as bupivacaine, and later also used to treat a variety of other lipophilic drug poisonings. The research on the treatment of ILE is still in the preliminary stage and relatively limited. A systematic review of fat emulsions for the treatment of acute poisoning found that the overall quality of the studies supporting this treatment is low or very low, but the included case reports indicate that fat emulsions are effective against verapamil, beta blockers, and certain Tricyclic antidepressants, bupivacaine, chlorpromazine, and certain antiarrhythmic drugs (eg, flecainide) poisoned patients have certain benefits. ILE may help treat patients who are hemodynamically unstable due to poisoning by these drugs.In view of the fact that the research on the treatment of ILE still needs to be further improved and related adverse reactions need to be further explored related countermeasures, the investigators plan to launch a registration research program related to the application of fat emulsion.
PROBLEM TO BE SOLVED: To improve the stability on application to the living body by controlling the free moisture content of a heat generating material composition enclosed in an air-permeable container. SOLUTION: A metal powder in an amount of 100 pts.wt. is blended with 1-15 pts.wt. metal chloride, 15-100 pts.wt. water, 0.05-15 pts.wt. water absorbent whose water absorbency reversibly changes depending on temperature rise or fall due to a heat generating reaction, and if necessary, a heat generating aid in an amount of 1-20 pts.wt. based on 100 pts.wt. iron powder, 0.1-5 pts.wt. pH adjustor, and 1-10 pts.wt. water-retentive agent or 0.5-5 pts.wt. surfactant to give a heat generating material composition 2. This composition 2 is enclosed in an air-permeable container, bag or sheet-form bag 3 having a moisture permeability of 50-5,000g/m<2> .24hr to give a heat generating article 1.  The free moisture content of the composition 2 is altered so that the heat generating reaction is slowed down when the temperature realized by heat generation rises above a prescribed temperature while the reaction is accelerated when the temperature realized by heat generation drops below a prescribed temperature.
FIELD: cosmetics industry. SUBSTANCE: skin care cosmetic can be used in the form of evening creams and also in the form of cosmetic masks. Cosmetic means has base in the form of gel, extract from embryos of mammals, biologically-active additives of natural and chemical origin. Used in function of mammals embryos is extract of human embryos. Proportioning of base and biologically-active additives of natural and chemical origin is as follows (0.59-5.3): 1.0, and ratio of components is as follows, mas.%: extract of human embryos 0.5-4.0, base and biologically-active additives of natural and chemical origin are proportioned as (0.59-5.3):1.0 - the balance up to 100%. Application of aforesaid compound ensures more effective regenerative action on skin connected with preventing fading and ageing of skin, retention and increasing its elasticity and maintaining good condition during long period of time. EFFECT: higher efficiency. 2 cl, 4 ex
250,230. Macdonald, W. J. April 3, 1925, [Convention date]. Hypodermic injections.-Substances for injection to reduce arterial hypertension are prepared by making an extract or liver or related glands, purifying the extract, and fractionally precipitating two active substances therefrom. In an example, calf liver is ground in the presence of chloretone, and extracted with Locke's solution containing a trace of sulphuric acid. The solution is filtered and evaporated to dryness under reduced pressure. The residue is extracted with alcohol and the solution filtered and evaporated to dryness in an air current. The substance so obtained is taken up in physiological salt solution and sterilized by filtration through a Berkefeld filter. Two active substances are separated from the extract by adding an equal volume of alcohol and then gradually adding acetone to precipitate first an oily substance, which is then removed, and finally a solid white substance. The oily substance is centrifuged, decanted off from any solid material present, purified if necessary by re-solution and precipitation, taken up in normal saline and passed through a Berkefeld filter. The solid precipitate obtained on adding more acetone after removal of the oily substance is removed from the solution by filtration, purified if necessary by re-solution and precipitation, dried in an air current, dissolved in normal saline, and the solution passed through a Berkefeld filter. To prevent precipitation on standing, the hydrogen ion concentration of the solution is adjusted by addition of sulphuric acid. The two active substances may be employed separately or mixed together. The Specification as open to inspection under Sect. 91 (3) (a) relates also to the preparation of the active substances from blood, lung, spleen, pancreas, thymus, heart, kidney or muscle. This subject-matter does not appear in the Specification as accepted.
We will train Swope providers in contraceptive counseling before intervention. We will recruit up to 85 women with substance abuse disorder (or opioid abuse disorder) from recovery centers. Eligible women will complete a baseline survey. Study staff will provide a referral for participants to seek more information on contraception and services. Women will have direct access to contraceptive counseling and services on-site via the mobile medical unit if they choose to use it. Counseling will focus on presenting the most effective contraceptive methods first (i.e., LARC). If women participate in contraceptive counseling, study staff will record the uptake of contraceptive medication and clinic referral at the time of enrollment and conduct follow-up surveys at 2-weeks, 1-month, and 3-months post-enrollment. If the participant refuses contraceptive counseling on MMU, a referral will be given.
Introduction. Dengue has been the most widespread mosquito-borne disease worldwide in recent years. It develops with a broad spectrum of clinical manifestations and sometimes progresses to a critical condition known as severe dengue. It is managed with supportive treatment. Available information about its clinical, epidemiological, and laboratory characteristics in the pediatric population is limited. Objective. To describe the clinical, epidemiological, and laboratory characteristics of dengue. Population and methods. Descriptive, observational, and retrospective study. It included patients aged 1 to 180 months seen due to probable or confirmed dengue at a children's hospital between 1/1/2020 and 5/31/2020. Results. A total of 85 patients with positive microbiological or clinical-epidemiological criteria were included. Of these, 25 (29%) were confirmed by RT-PCR; all corresponded to DENV-1 serotype. Patients' median age was 108 months (interquartile range: 84-144). The main clinical manifestations were fever, headache, and myalgia. The most important laboratory findings were leukopenia, thrombocytopenia, and high transaminase levels. Conclusion. The recognition and understanding of clinical and laboratory alterations that occur during dengue disease may allow an effective approach and help to reduce the more severe clinical form in children.
A four year prospective non-randomized feasibility implementation study for lung cancer screening in a targeted high-risk population of heavy (ex-)smokers by low-dose CT, combined with a smoking cessation intervention. It will be coordinated by a consortium of researchers from UZA and UAntwerpen.

Lung cancer (LC) remains the leading cause of cancer mortality, worldwide and in Belgium. Prevention and early detection are considered the cornerstones to increase the chances of successful treatment and improved outcomes. There is strong scientific evidence that screening for lung cancer through an annual low-dose CT scan (LDCT) in a high-risk population of (ex-)smokers significantly reduces lung cancer mortality and is cost-effective. This implementation study will investigate the participation rate of eligible high risk (ex-)smokers in the First Line Zone (ELZ) South East Region of Antwerp (ZORA) in a LDCT screening program, combined with smoking cessation. Besides, other indicators of compliance, quality and turn-around-time will be estimated. It will give insights in the feasibility and potential challenges of implementing a LDCT lung cancer screening program in our region. This implementation project is in line with the European Commission Council recommendation of December 2022 to explore the feasibility and effectiveness of LDCT in a high-risk population. Findings from this study will contribute valuable evidence for policymakers and stakeholders. Furthermore, an implementation pilot is a prerequisite for a future high-quality population-based screening program.