anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a preparation method of a sustained-release medicine film. Sea buckthorn oil, glycerine, chitosan and bletilla striata are prepared into a circular medicine film, which is used for treatment for various tympanic membrane perforation, thus allowing the patients to avoid the operations, reducing the medical cost and being popularized in all levels of hospitals. The treatment cost of the tympanic membrane perforation by the medicine film is about one tenth of the operation cost, and the medicine film can promote the good healing of the tympanic membrane perforation, which can essentially replace the operation treatment. The operation treatment for the tympanic membrane perforation has high medical cost and is difficult to achieve the good healing of the tympanic membrane. The western region of China is rich in sea buckthorn resources which can maintain water and soil, green the environment, keep the ecological balance, and is in line with the policy of returning farmland to forest in the western loess plateau region of China. Thus, the development and the utilization of the sea buckthorn resources have important economic value and social significance. The research and development of the medicine film has great social and economic benefits, and promising prospects of popularization and application. The invention opens up the medicine film for the treatment for tympanic membrane perforation which is in line with the China's actual conditions.
Process comprises mixing at pH 1.2-1.6, ferric chloride and alkali carbonate solns., and then e.g. dextran soln. Mixt. is neutralised with alkali soln. to pH 2-2.2, and then 4-4.5. - Dextran polymer gel microsphere columns exclude the free hydrocarbon and the complex, and the complex only, respectively, based on the gel pore sizes.
OBJECTIVE: Pigtail thoracostomy (PT) has become the mainstay technique for the drainage of pediatric pleuropneumonic effusions (PLPe). However, its efficacy and complication profile has been questioned when compared with video-assisted thoracoscopic surgery and larger bore traditional tube thoracostomy. The aim of this study was to assess the efficacy, safety, and complications associated with PT.
METHODS: A cross-sectional study at a freestanding tertiary children's hospital. We extracted the medical records of all children aged younger than 18 years treated with PT for PLPe from June 2016 to June 2020. The primary efficacy outcome was treatment failure defined as the need for a repeat drainage procedure, thoracostomy, or video-assisted thoracoscopic surgery. Secondary efficacy outcomes were length of hospital stay (LOS) and duration of in situ PT. The primary safety outcomes were adverse events during or after insertion. We also recorded any associated complications.
RESULTS: During the study period, 55 children required PT. The median age was 25 months (interquartile range, 14-52) and 58.2% were boys. Eight (14.4%) were bacteremic or in septic shock. There were no adverse events related to insertion. Forty-two (76.3%) children were treated with fibrinolysis. There were 2 (3.6%) treatment failures. The median LOS and PT durations were 13 and 4 days (interquartile ranges, 10-14.8, 3-6.7), respectively. Eight (14.4%) children experienced complications that were nonoperatively managed.
CONCLUSIONS: Our findings suggest that PT drainage offers a safe and highly effective option for managing PLPe and carries a very low failure rate.
Cefuroxime is excreted unchanged in the urine; in adults, approximately 50% of the administered dose is recovered in the urine within 12 hours. The pharmacokinetics of cefuroxime in the urine of pediatric patients have not been studied at this time. Until further data are available, the renal pharmacokinetic properties of cefuroxime axetil established in adults should not be extrapolated to pediatric patients.

Because cefuroxime is renally excreted, the serum half-life is prolonged in patients with reduced renal function. In a study of 20 elderly patients (mean age = 83.9 years) having a mean creatinine clearance of 34.9 mL/min, the mean serum elimination half-life was 3.5 hours. Despite the lower elimination of cefuroxime in geriatric patients, dosage adjustment based on age is not necessary (see PRECAUTIONS: Geriatric Use).
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade chronic inflammatory disease and has associated comorbidities. Different nutritional strategies are used for the purpose of weight loss, highlighting low-carbohydrate (LC) diets, ketogenic diets, and intermittent fasting (IF). These strategies can lead to metabolic and behavioral changes as they stimulate different biochemical pathways. Therefore, this study evaluated memory, energy metabolism, neuroinflammation, oxidative stress, and antioxidant defense parameters in mice subjected to an LC diet, ketogenic diet (KD), or IF. Eighty male Swiss mice, 60 days old, were divided into 4 groups: control, LC, KD, or IF. Body weight was measured weekly, and food intake every 48 h. After 15 days of nutritional interventions, the animals were subjected to the behavioral object recognition test and subsequently euthanized. Then, visceral fat was removed and weighed, and the brain was isolated for inflammatory and biochemical analysis. We concluded from this study that the LC and KD strategies could damage memory, IF improves the production of adenosine triphosphate (ATP), and the LC, KD, and IF strategies do not lead to neuroinflammatory damage but present damage at the level of oxidative stress.
The present invention relates to a process for preparing hydrophobized hyaluronate (of the general formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of the hydrophobized hyaluronate serving as a carrier of biologically active hydrophobic substances. The hydrophobization of hyaluronate is carried out through an esterification reaction of hyaluronate with long-chain carboxylic acids, the latter being activated by a halide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronate. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication. Hyaluronic nanomicelles support the penetration of bound substances in topical applications and enable the bound substances to be transferred into the individual cells. The nanomicelles obtained from hydrophobized hyaluronate derivatives are usable in cosmetic and pharmaceutical applications.
FIELD: medicine, microbiology. SUBSTANCE: invention relates to a medicinal preparation prepared from the strain Staphylococcus aureus C2 GISK N 222 after preliminary the development stage. An agent shows biological activity 19%, not less, by an index of elimination of an inflammatory response containing protein in concentration 0.0063-0.063 mg/ml in an inhalation form and providing a size of inhaling particles 2-5 mcm that ensures to treat diseases affecting low respiratory ways bronchi, bronchioles, alveoles, in part, bronchial asthma. The preparation has a low protein load on patient and in distinction with other similar preparations has nonhormonal origin. EFFECT: enhanced effectiveness of agent, valuable medicinal properties. 3 tbl, 2 ex
Patients receive cyclophosphamide IV over 30-45 minutes on day 1 and fludarabine IV over 10-20 minutes on days 1-5. Treatment repeats every 28 days in the absence of disease progression for a minimum of 4 courses and a maximum of 6 courses.
Between 10 percent and 20 percent of patients with hypercortisolism (Cushing syndrome) have ectopic production of adrenocorticotropin hormone (ACTH) that causes cortisol excess. In approximately 50 percent of these patients, the source of ACTH cannot be found despite very detailed and extensive examination including imaging studies such as computed tomography scanning, magnetic resonance imaging, and octreotide scan (octreoscan) using the conventional low dose of indium-111 pentetreotide. The sensitivity and specificity of these imaging studies depends on anatomic alterations and/or the dose and adequate uptake of radiopharmaceutical. In contrast, positron emission tomography (PET) has the ability to detect pathologic tissue based on physiologic and biochemical processes within the abnormal tissue. This protocol tests whether fluorine-18 dihydroxyphenylalanine (F-DOPA) or use of a higher dose of indium-111 pentetreotide (Octreoscan) can be used to localize successfully the source of ectopic ACTH production. In addition the study examines whether administration of the glucocorticoid antagonist mifepristone can improved the sensitivity of the standard dose Octreoscan. Eligible patients participating in this arm of the study will have a second standard dose scan. Others will receive a higher dose octreoscan instead.
NEW MATERIAL: Aluminum salt of acylated dibasic amino acid expressed by formula I (R is a 5-10C hydrocarbon chain; R' is main chain of an α-amino acid). EXAMPLE: Aluminum dihydroxy undecylenoyl collagenate. USE: This compound has perspiration preventing properties useful for perspiration preventing agent. Also has anti-inflammatory properties useful for medicine. This compound is insoluble in water and manifests 4-6pH when dispersed in water by using a humectant, free from coagulation of protein, denaturation and no stimulation on user. PROCESS: The compound is obtained by carrying out a reaction of an alkaline metal salt of the acylated amino acid of formula II (M is an alkali metal) and aluminum sulfate or aluminum chloride in water solution while keeping the pH of the reaction medium roughly to neutral by addition of a base. Then the reaction medium is controlled to 4-5pH at the end of the reaction by the addition of aluminum sulfate or a mineral acid allowing to obtain the compound of the formula I.
PROBLEM TO BE SOLVED: To obtain the subject preparation expected to have anticancer effects, having extremely high practicality, and useful for the therapy of progressive cancer and last stage cancer, and the improvement of quality of life by including a specific cytokine inducer. SOLUTION: This preparation contains an interleukin 12 inducer. The inducer is preferably (A) a component derived from a mycelium of a mushroom. The inducer preferably contains further (B) the mycelium component of the mushroom, and (C) a microbial cell component of hemolytic streptococcus. The component A is a physiologically active substance obtained by treating the mycelium of the mushroom with an enzyme, and preferably contains a β3-(1→3)D-glucan, a β-(1→6)D-glucan, a heteroglycan, a peptidoglycan, a proteoglycan, a lectin, an indigestive polysaccharide or the like. The daily dose of the preparation as an anticancer agent is usually 100-20,000 mg, especially 1,000-10,000 mg per adult as the amount of the orally administered active ingredient.
Risk of Contamination: Advise patients not to touch the dropper tip to any surface to avoid contaminating the contents.

Concomitant Use of Contact Lenses: Advise patients not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

Potential for Hypersensitivity Reactions: Systemically administered quinolones including moxifloxacin have been associated with hypersensitivity reactions, even following a single dose. Instruct patients to discontinue use immediately and contact their physician at the first sign of a rash or allergic reaction. [see Warnings and Precautions (5.2)].

Rx Only
OBJECTIVE: To describe the incidence, etiology, clinical signs, diagnostics, treatments, and outcome of noniatrogenic traumatic pneumomediastinum (TPM) in dogs and cats.
DESIGN: Retrospective study of cases (2005-2022).
SETTING: University veterinary teaching hospital.
ANIMALS: Fifty-two patients (29 dogs, 23 cats).
MEASUREMENTS AND MAIN RESULTS: Data collected from the medical records included signalment, physical examination findings, animal trauma triage (ATT) score, clinicopathological data, imaging data, surgical intervention, length of hospitalization, supportive care, complications, and outcome. Most dogs presented with tachycardia and tachypnea, while cats presented with hypothermia and tachypnea. Subcutaneous emphysema, pneumothorax, and dyspnea were the most common clinical signs for both species. The median calculated ATT score was 3.5 in dogs and 4 in cats. The most common radiographic abnormalities other than pneumomediastinum were pneumothorax and lung contusions. The overall mortality rate was 18%, with a significantly higher survival rate in dogs (26/28 dogs [93%], 15/22 cats (68%); P = 0.03). Outcome was unknown in 1 dog and 1 cat. The only significant difference in treatment between survivors and nonsurvivors was the requirement in dogs for positive pressure ventilation. The median hospitalization period was 2 days for both species, with a shorter hospitalization in the nonsurvivors (0.6 vs 2 days, respectively; P = 0.006).
CONCLUSIONS: TPM is an infrequent pathology in veterinary medicine and may be seen without an externally obvious injury. The most common causes for TPM in dogs were vehicular trauma and bite wounds, while high-rise syndrome was the most common cause in cats. Most of the cases have concurrent pneumothorax and require thoracocentesis; however, direct intervention to treat TPM is not usually required. The vast majority of cases did not undergo surgery to treat TPM. The prognosis for dogs with TPM was good but was guarded for cats.
Because injuries to the PCL and posterolateral structures occur with less frequency than other structures in the knee joint (such as the anterior cruciate ligament and menisci), fewer studies are available to assist the surgeon and patient with appropriate decision-making regarding conservative versus surgical treatment. The majority of patients who sustain injury to these structures are treated conservatively. Unfortunately, several investigations describe noteworthy symptoms and functional limitations following conservative management, and a high percentage of patients develop knee osteoarthritis that can be disabling for both recreational and daily activities. The investigators of this study have nearly three decades of experience and have extensively studied the effects of this injury in both the laboratory and clinic settings. It is our opinion that surgical reconstruction provides significant benefit when appropriately indicated, as has been demonstrated in our previous studies. Especially in athletic individuals, PCL and posterolateral reconstructive procedures have advanced to the point where more predictable results can be expected to restore sufficient knee function. Studies have demonstrated, at least in the short-term, that the majority of patients with acute ligament ruptures treated with reconstruction are able to return to various levels of sports activities.12 Whether these procedures will decrease the risk of the patient developing future osteoarthritis is unknown and requires further study.
A significant number of the genetic alterations observed in cancer patients lie within nonprotein-coding segments of the genome, including regions coding for long noncoding RNAs (lncRNAs). LncRNAs display aberrant expression in breast cancer (BrCa), but the functional implications of this altered expression remain to be elucidated. By performing transcriptome screen in a triple negative BrCa (TNBC) isogenic 2D and 3D spheroid model, we observed aberrant expression of >1000 lncRNAs during BrCa progression. The chromatin-associated lncRNA MANCR shows elevated expression in metastatic TNBC. MANCR is upregulated in response to cellular stress and modulates DNA repair and cell proliferation. MANCR promotes metastasis as MANCR-depleted cells show reduced cell migration, invasion, and wound healing in vitro, and reduced metastatic lung colonization in xenograft experiments in vivo. Transcriptome analyses reveal that MANCR modulates expression and pre-mRNA splicing of genes, controlling DNA repair and checkpoint response. MANCR promotes the transcription of NET1A, a Rho-GEF that regulates DNA damage checkpoint and metastatic processes in cis, by differential promoter usage. Experiments suggest that MANCR regulates the expression of cancer-associated genes by modulating the association of various transcription factors and RNA-binding proteins. Our results identified the metastasis-promoting activities of MANCR in TNBC by cis-regulation of gene expression.
Hepatocellular carcinoma (HCC) is one of the most common malignancies and ranks fourth in terms of cancer-related mortality worldwide . Unfortunately, the diagnosis of HCC is often made late in the cure of the disease when the tumour has spread outside the liver parenchyma as portal vein invasion or distant metastases. In the history of HCC patients, a significant proportion will sooner or later face systemic therapies as they are no longer eligible for radical or locoregional therapies. Cytotoxic chemotherapy and hormonal therapies have never shown significant benefit on overall survival (OS) . The first systemic therapy to show a significant beneficial impact on HCC outcome was the tyrosine kinase inhibitor (TKI) sorafenib, an anti-angiogenic agent (AAA) with anti-proliferative properties on HCC . For nearly a decade, all systemic therapies tested in randomised controlled trials as first-line systemic therapy (1L) head-to-head with sorafenib, or as 2L after sorafenib failure have not shown significant benefit. In 2018, Kudo et al. showed that lenvatinib, another TKI with anti-angiogenic properties, was at least equivalent to sorafenib in 1L in the REFLECT non-inferiority trial \[5\]. Other AAA TKIs with anti-cancer properties on HCC cells have demonstrated efficacy in 2L: regorafenib after progression on sorafenib in 2017 , and cabozantinib after progression on or intolerance to sorafenib in 2018 . In addition, ramucirumab, a monoclonal antibody targeting VEGFR-2, has shown significant benefit in a specific subpopulation of HCC patients with high baseline alpha-fetoprotein levels ≥ 400 ng/ml . However, all these options were strictly palliative with no long-term survivors and lack of potential recovery. Immuno-oncology (IO) approaches have completely revolutionised the paradigm of systemic HCC therapies with nonetheless a significant increase in median OS in IO-based combination strategies, but also the emergence of the possibility of long-term survivors and, for some patients, hope for a complete response and possibly a final cure.
This group will be recruited from an ongoing observational study at our centre. The patients in this group have all received the standard care for treating gastroschisis and any potentially associated bowel obstruction. They have not received Gastrografin. They will be recruited between May 2010 and May 2019.
This is a multi-center, randomized, double blinded, parallel-group study to assess the Immunogenicity and safety of NBP608 compared to Zostavax which are indicated for the prevention of herpes zoster. Total of 646 healthy subjects aged 50 and over are enrolled, and each subject is administered with single dose of vaccine which is randomly assigned to low, high potency of NBP608 group and Zostavax group in 1:1:2 ratio. Stratified randomization for age group is used to achieve the balance of treatment assignment within age strata.

Total of six visits are scheduled including two visits via telephone contact. Blood sampling is conducted for immunogenicity assessment before and 6 weeks, 52 weeks after vaccination at Visit 2, Visit 4, Visit 6 respectively. Safety is monitored 1 week, 6 weeks, 26 weeks and 52 weeks after vaccination through Visit 3\*, Visit 4, Visit 5\*, Visit 6. (\* telephone contact)
The invention discloses an externally applied paste of Chinese medicinal herbs used for treating cervical spondylosis, which is prepared by roughly grinding 3g of musk, 20g of safflower, 60g of garter snake, 100g of himalayan teasel root 100g of pubescent angelica root, 100g of suberect spatholobus Stem, 50g of earthworm, 10 centipede, 1 agkistrodon, 30g of coral ardisia roots, 50g of loquat leaves, 100g of rhizoma belamcandae, 50g of lonicera, 100g of european verbena, 60g of sanchi, 50g of myrrh, 100g of zedoary, 100g of common burreed rhizome, 80g of common floweringquince fruit, 80g of costustoot, 80g of akebia stem, 80g of ricepaperplant pith and 80g of beautiful sweetgum fruit, fully mixing the powder with 5kg of aged vinegar and 2kg of honey, uniformly mixing the mixture. The paste stands for 20 days. Then the paste is coated on a wound which is then wrapped by a cloth. After the paste is dry, the cloth is removed. The paste is coated in the morning and in the evening everyday. The paste has the positive effects of obvious curative effect in a short time, stable effect after the wound is healed, no relapse and no any toxic and side effect.
An herbal preparation for stimulation of hair growth and control of hair fall, dandruff and infections thereof using herbaceous plants, Ageratum spp. At least one compound of plants, Ageratum spp. such as, for example, N,N-bis(trimethylsilyl)-2-phenyl-7-(trifluoromethyl)quinolon-4-amine, 3',4',5,6,7,8-hexamethoxyflavone, Phytol, Precocene, Caryophyllene, Squalene, a-linolenic acid, 9,12-octadecadienoic acid (Z,Z)-, Hexadeconoic acid and Hydrocoumarin can be extracted utilizing a Common Plant Extraction Approach. The extraction of the compounds can be performed utilizing an ethanol solvent and a methanol solvent (i.e., alcoholic solvents) separately and the concentrated materials obtained at both the solvents are pooled together or used independently in order to obtain an herbal extract for simulating the follicles of the hair. The compounds of plants Ageratum spp. in combination with an acceptable carrier or diluent can be further prepared into an herbal extract formulations such as, aqueous (including shampoo), oil or gel for topical application. Such an herbal preparation using plants, Ageratum spp. can be utilized as an efficient hair care solution in a wide range of hair growth related problems of humans in a cost effective manner.
Participants will receive single oral dose of JNJ-64140284 Regimen 1 in fasted condition (Treatment A) followed by JNJ-64140284 Regimen 2 in fasted condition (Treatment B), then JNJ-64140284 Regimen 5 in fed condition (Treatment E) followed by JNJ-64140284 Regimen 3 in fed condition (Treatment C) and, then JNJ-64140284 Regimen 4 in fed condition (Treatment D) in Treatment Periods 1 to 5 respectively. All treatment periods will be separated by a wash out period of at least 5 days and maximally 12 days.