anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Oral microbiota; While it is associated with systemic diseases such as obesity, diabetes and cancer, it is also associated with oral diseases such as oral cancers, tooth decay and gum diseases. Nutrition is seen as an important factor in maintaining oral health. In particular, the amount and frequency of sugar consumption, the type and consistency of food, the frequency of eating, the consumption of cariogenic foods with other foods and the duration of carbohydrates remaining on the teeth are among the factors that affect oral health. The aim of this study is to examine the relationship between oral microbiota and eating habits, sleep quality and hedonic hunger in adolescents. The study is planned to be carried out in 4 stages. First stage; A survey form will be filled out that questions general information about children, oral health practices, nutritional habits and frequency of food consumption. In the second stage; Children's anthropometric measurements (body weight (kg), height (cm), waist circumference (cm) will be taken and bioelectrical impedance analysis (BIA) results will be recorded. In the third stage, oral examinations of the children will be performed. In the final stage, saliva samples of the children will be collected. Bacteria Logarithmic values will be used when comparing the concentrations between groups. The suitability of the parameters to normal distribution will be evaluated with q-q graphs and Shapiro-Wilk test. Student t test will be used for variables that comply with normal distribution and Mann Whitney U test will be used for changes that do not comply with normal distribution. The relationship will be evaluated with the Spearman or Pearson correlation test according to the normality distribution. IBM SPSS (Statistical Package for Social Sciences) 22.0 package program will be used when evaluating the data obtained as a result of the study. While examining the hypothesis tests, α = 0.05 and accordingly the confidence interval will be determined as 95%. It will be evaluated at p\<0.05 level. In order to enable healthy adolescents to reach a good standard of living, there is a need for a more accurate understanding of the relationship between oral microbiota, nutrition and sleep. As a result of this study, it is aimed to reveal the relationship between oral microbiota and eating habits, sleep quality and hedonic hunger in adolescents.
Treatment duration will be 8 weeks. Conventional treatment will include education about defecation and physiology, dietary advices and laxative therapy. In the first session education and dietary advices will be given to patient. Dietary advices will be given by dietitian. Laxative therapy will be given by pediatric surgery.
Patients will receive a SSRI (sertraline or citalopram) for 12 weeks. Dose will be adjusted every 4 weeks according to medical criteria.
AIM: A treatment strategy for patients with a significant polyp or early colon cancer (SPECC) of the rectum presents a challenge due to the significant rate of covert malignancy and lack of standardized assessment. For this reason, NICE recommends multidisciplinary meetings to improve outcomes. The primary aim of the present study was to report the performance of our specialist early rectal cancer (SERC) multidisciplinary team (MDT) in correctly substratifying the risk of cancer and to discuss the limitations of staging investigations in those patients with "poor outcomes".
METHOD: This was a retrospective review of patients referred to our SERC MDT from 2014 to 2019. Lesions were assigned by the MDT to three pre-resection categories (low, intermediate, high) according to the risk of covert malignancy. Resection method and final histology were compared to the pre-resection categories.
RESULTS: Of 350 SPECC lesions, 174 were assessed as low-risk, 108 intermediate-risk and 68 high-risk. The cancer incidence was 4.8%, 8.3% and 53%, respectively (15.5% overall). Eight lesions were categorized as low-risk but following piecemeal resection were found to be malignant. Five lesions, three of which were categorized as high-risk, were ultimately benign following conventional surgery. One pT1sm1 cancer, removed by anterior resection, may have been treated by local excision.
CONCLUSION: A total of 83% of malignant polyps were triaged to an en bloc resection technique and surgical resection avoided for nearly all benign lesions. However, 12 patients from this cohort were deemed to have a poor outcome because of miscategorization. Further comparative research is needed to establish the optimum strategy for rectal SPECC lesion assessment.
ORIGINALITY STATEMENT: There is currently no consensus for staging significant polyps of the rectum. This paper reports the effectiveness of a specialist early rectal cancer MDT to correctly risk-stratify significant rectal polyps. It underscores the importance of accurate categorization for treatment decision-making, while acknowledging the limitations of current staging modalities.
The evaluation of chest pain patients in the emergency department remains a costly and difficult challenge, because a large proportion of them do not suffer from an acute coronary syndrome (ACS). The adequate ruling out of ACS in patients with chest pain is crucial, as the erroneous discharge of a patient with ACS is associated with a high risk of cardiac events. Rapid assessment of these patients is critical to direct further diagnostic and therapeutic strategies. Electrocardiography (ECG) and cardiac troponin (cTn) are the current diagnostic cornerstones and complement clinical assessment in current AMI guidelines1. They allow to rule in an acute myocardial infarction (AMI) within the first 3 hours after presentation in the majority of patients and offer the opportunity to initiate appropriate, evidence-based treatment. The vast majority of patients presenting to the Emergency Department (ED) with suspected AMI, however, finally prove not to have AMI. The current process of ruling out AMI is time-consuming and expensive. One fourth to one-third of patients with AMI present without significant ECG changes indicative of acute ischemia; therefore, the ECG is of little help to rule out AMI, especially in the setting of non-ST elevation ACS (NSTE-ACS). High-sensitivity (hs)-cTn assays have been developed recently, enabling measurements of concentrations that are ∼10-fold lower than those previously measurable. Recent studies have confirmed the increased accuracy of these high-sensitivity assays compared with conventional assays in the early detection of AMI and in the safely ruling in or out of coronary causes of chest pain. However, concerns have been raised about a possible specificity deficit with these new assays. In addition, a second measurement of hs-cTn may be warranted in order to increase the accuracy of the assay.

Copeptin, the C-terminal part of the vasopressin pro-hormone, and a marker of acute endogenous stress, has been demonstrated to be useful for a more rapid ruling out of acute myocardial infarction. Current evidence for the diagnostic validity and performance of a combination of high sensitivity-cardiac troponin and copeptin is limited and controversial. A Bayesian probabilistic approach is likely to be the correct way to evaluate the possible incremental value of copeptin in the detection of ACS. Thus, we aim at prospectively evaluating the diagnostic accuracy of copeptin, hs-cTn, CK-MB and myoglobin, alone or in combination with hs-cTn, for the early diagnosis and ruling out of Non-ST-Elevation (NSTE) ACS versus non-cardiac causes of chest pain in a selected cohort of Emergency Department (ED) chest pain patients according to their pre-test probability, as assessed through a combination of two validated clinical risk score systems (i.e. Chest Pain Score and TIMI Risk Score).
The invention comprises substituted-benzoic acid esters of Vitamin-A in which the substitution consists of one or two amino groups which may be alkylated or acylated.  Specified compounds are Vitamin-A p-amino-benzoate, and the corresponding m-amino, o-amino, 3,5-diamino, p-dimethylamino, and p acetamino-derivatives.  These compounds may be made by esterifying Vitamin-A or a derivative such as Vitamin-A alcohol or Vitamin A-acetate with a benzoic acid, or a reactive functional derivative thereof, carrying one or two amino groups, which may be alkylated or acylated, or one or two radicals which may be transformed into amino groups, transforming the said radicals (if present) into amino groups and, if desired, acylating any amino group or groups present.  In the case of alkylated and acylated amino-benzoic acid compounds the substituents on the amino groups are preferably lower alkyl radicals such as methyl or ethyl radicals, and acyl radicals derived from lower alkanoic acids such as acetyl radicals, or aromatic carboxylic acid radicals such as benzoyl. In a typical Example (No. 1), Vitamin A alcohol was added to a solution of p-nitro-benzoyl chloride in absolute pyridine in an atmosphere of nitrogen and allowed to stand to produce Vitamin-A p-nitro-benzoate which was subsequently dissolved in alcohol and toluene and reduced in the presence of hydrogen and nickel to produce Vitamin-A p-amino benzoate.
30-50 subjects aged from 20 to 80 years old without sleep apnea or with low arousal threshold obstructive sleep apnea will be enrolled in this randomized, double-blind, cross-over, and placebo-controlled 8-week period experiment.

At the treatment period (0th to 8th week of the experiment), subjects will receive 2 placebo or capsules of sesame complex (37-56mg sesamin per capsule). The 9th to 11th week will be the washout period. The control and sesamin group will be cross-over at 11th week to 12th week of the experiment. Sleep quality, life quality examination and anti-oxidative functions will be carried out in this study. The basic anthropometric examination will be carried out at the beginning, 4th, 8th, 11th, 15th, and 19th week of the study. Routine laboratory parameters including liver function, kidney function, blood sugar, lipid profile, and anti-oxidative status will be investigated at the beginning, 8th, 11th and 19th week of the study. The questionnaire evaluation including the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, and Short form-12 items health survey will be investigated at the beginning, 8th, 11th, and 19th week of the study. We expect that sesame complex including 37-56mg sesamin may improve oxidative status which in turn ameliorates the sleep quality, life quality, and anti-oxidative functions in patients with sleep disorder.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. 

Epidural Use in Labor and Delivery

Epidural sufentanil was tested in 340 patients in two (one single-center and one multicenter) double-blind, parallel studies. Doses ranged from 10 to 15 mcg sufentanil and were delivered in a 10 mL volume of 0.125% bupivacaine with and without epinephrine 1:200,000. In all cases sufentanil was administered following a dose of local anesthetic to test proper catheter placement. Since epidural opioids and local anesthetics potentiate each other, these results may not reflect the dose or efficacy of epidural sufentanil by itself. 

Individual doses of 10 to 15 mcg sufentanil plus bupivacaine 0.125% with epinephrine provided analgesia during the first stage of labor with a duration of 1 to 2 hours. Onset was rapid (within 10 minutes). Subsequent doses (equal dose) tended to have shorter duration. Analgesia was profound (complete pain relief) in 80% to 100% of patients and a 25% incidence of pruritus was observed. The duration of initial doses of sufentanil plus bupivacaine with epinephrine is approximately 95 minutes, and of subsequent doses, 70 minutes. 

There are insufficient data to critically evaluate neonatal neuromuscular and adaptive capacity following recommended doses of maternally administered epidural sufentanil with bupivacaine. However, if larger than recommended doses are used for combined local and systemic analgesia, e.g. after administration of a single dose of 50 mcg epidural sufentanil during delivery, then impaired neonatal adaption to sound and light can be detected for 1 to 4 hours and if a dose of 80 mcg is used impaired neuromuscular coordination can be detected for more than 4 hours.
The utility model relates to a self-heating medicinal plaster, which belongs to a thermotherapy apparatus and is composed of an ointment plaster and a self-heating bag. The ointment plaster is composed of a piece of backing cloth, a medicinal adhesive layer and a protective film of the medicinal layer. The self-heating bag is provided with a plurality of air holes that are glued with sealing covers. The self-heating bag is fixed at the upper side of the backing cloth of the ointment plaster, which is opposite to the medicinal adhesive layer. The self-heating bag can be divided into a plurality of small bags that are respectively fixed on the backing cloth. The self-heating medicinal plaster has the functions of medicinal therapy, acupuncture therapy and health care as well.
Patients in 9-minute withdrawal group will be carefully observed for 9 minutes during the colonoscopy withdraw. A stop watch will be utilized to remind endoscopists the withdrawal time. The time to perform polyp biopsy will not be included in the 9 minutes.
Receive two cycles of cisplatin-based adjuvant chemotherapy 50mg/m2 D1 and gemcitabine 1000mg/m2 D1 and D8 at every 21 days. After that, patients will be followed with plasma cfDNA-HPV, computed tomography (CT) scan of the thorax and magnetic resonance (MRI) of abdomen and pelvis and clinical and gynecological examination at every four months.
FIELD: medicine. SUBSTANCE: polypeptide is isolated from venum of spider Agelenopsis aperta by chromatography at the range 20-230 nm on column type Vidac R  C-18 22x250 mm, pore size is 300  , particle size is 10 mcm. Column is eluted with a mixture of acetonitrile and 0.1% aqueous trifluoroacetic acid at gradient concentration of acetonitrile by the following programm: 0-30 min - 5-20% acetonitrile, 30-35 min - 20-70% acetonitrile in 0.1% trifluoroacetic acid. Rate flow is 15 ml/min. At 41.5 min fraction is collected which is subjected for chromatography on the same type column 10x250 mm with particle size 5 mcm. Column is eluted at the flow rate 3.5 ml/min with isocratic system of solvents consisting of 70% 0.1% aqueous trifluoroacetic acid and 30% acetonitrile at the same wavelength range. Fraction is collected at 7.5 min which is subjected for lyophilization. Polypeptide with mol. mass 5201 is obtained, and its amino-terminal amino acid sequence is determined. EFFECT: improved method of polypeptide preparing.
Hiatal hernia (HH) is a common disease in the general population. It is often asymptomatic, but if it does present clinical manifestations, these are usually gastrointestinal. Gastroesophageal reflux is the main symptom that accompanies it. Depending on the severity of the hernia, it is classified into several subtypes from I-IV. Especially, IV type (giant HH) can lead to various cardiopulmonary symptoms with several degrees of severity. It is necessary to keep this possibility in mind among the various differential diagnoses that may occur in this clinical setting. The current paper aims to review the literature on classic and novel information on the HH - cardiovascular system relationship. Epidemiological data, physiological aspects of the heart compressed by HH, cardiovascular symptoms, electrocardiographic changes, echocardiographic alterations and clinical implications are discussed.
INTRODUCTION: Ultrasonography (US) is used as a real-time dynamic imaging modality during neurosurgery. A novel Doppler US technique, Superb Microvascular Imaging (SMI), can be used to visualize low-velocity flow of small vessels at high resolution with high frame rates. We visualized vessel flow using this US SMI technique and contrast agent during cerebrovascular surgery.
METHODS: Forty-three patients with an unruptured cerebral aneurysm (control), ischemic and hemorrhagic moyamoya disease, carotid artery stenosis, hemangioblastoma, severe stenosis of the middle cerebral artery, venous angioma, and intracerebral hemorrhage (ICH) underwent neurosurgery with US SMI monitoring using a contrast agent. The diameter, length, and number of penetrating vessels were analyzed in patients with an unruptured cerebral aneurysm (control), moyamoya disease, and ICH.
RESULTS: Diameter and length of cerebral penetrating vessels were significantly increased in patients with moyamoya disease and ICH compared to control patients. The number of penetrating vessels was increased in moyamoya disease patients compared to control and ICH patients. In hemorrhagic moyamoya disease, flow in the penetrating vessels originated from a deep periventricular point and extended to the cerebral surface. Pulsatile cerebral aneurysms during clipping surgery and carotid artery stenosis during carotid endarterectomy were easily identified by SMI. Drastically increased vessel flow in patients with a hemangioblastoma or a venous angioma was observed.
CONCLUSION: Using the US SMI technique and contrast agent, we obtained useful flow information of the vascular disease structure and intracerebral deep small vessels during cerebrovascular surgery. Further quantitative analysis will be informative and helpful for cerebrovascular surgery.
PURPOSE:To impart heat resistance, water resistance, cold resistance or chemical resistance to a pressure-sensitive self-adhesive tape by providing a self-adhesive layer composed of an organopolysiloxane pressure-sensitive self-adhesive containing a specific amt. of an inorg. filler on one surface of a nonwoven fabric composed of a polyurethane elastic fiber. CONSTITUTION:A self-adhesive layer composed of an organopolysiloxane pressure-sensitive self-adhesive containing 1-10wt.% of an inorg. filler is provided on one surface of a nonwoven fabric composed of a polyurethane elastic fiber. A moisture-absorbable sheet is bonded to a part of the self-adhesive layer of a pressure-sensitive self-adhesive tape and a releasable sheet is further bonded to the entire surface of the self-adhesive layer. When the inorg. filler is added, the pressure-sensitive self-adhesive tape is bonded to an adherend at the time of use and, when the tape is peeled, no self-adhesive is left on the adherend. When an acrylic self-adhesive is added to the organopolysiloxane pressure- sensitive self-adhesive along with the inorg. filler, self-adhesive strength can be enhanced still more without leaving the self-adhesive on the adherend.
FIELD: medical engineering. SUBSTANCE: method involves combining at least two ingredients taken from animal tissues and/or being of human origin. Their denaturation is carried out mainly with carbamide applied to obtain homogeneous phase. The phase is divided into two parts. One of them is used for separating the given ingredient that is added to the rest portion next to it. Renaturation is carried out. EFFECT: improved properties; wider activity range. 5 cl
BACKGROUND AND PURPOSE: The choroid plexus contains specialized ependymal cells responsible for CSF production. Recent studies have demonstrated volumetric and perfusion changes in the choroid plexus with age and neurodegenerative disorders, however, volumetric changes in the choroid plexus in low pressure states is not known. The purpose of this study is to evaluate volumetric differences in choroid plexus size in patients with spontaneous intracranial hypotension (SIH) resultant from spinal CSF leaks compared with healthy controls.
MATERIALS AND METHODS: This was a retrospective, institutional review board-approved study. Patients with MRI evidence of SIH and a spinal CSF leak diagnosed on myelography and subsequently confirmed at surgery were included in this study. All patients included in this study including age-matched healthy controls had a brain MRI performed on a either a 1.5 or 3T scanner with acquisition of 3D T1 postcontrast (eg, BRAVO, MPRAGE, etc). In all patients, the trigonum ventriculi volume, in the atria of the lateral ventricles, was contoured by using Visage-7 segmentation tools on the volumetric postcontrast T1 sequence. A basic 2-tailed t test was used to compare choroid plexus volumes between the 2 groups.
RESULTS: Thirty-four patients were included with 17 patients with SIH with spinal CSF leak and 17 healthy control patients who were age- and sex-matched. The mean age of patients was 45 years, standard deviation 14 years. The mean volume of the choroid plexus for patients with SIH with spinal CSF leak was 1.2 cm3 (standard deviation = 0.26) compared with 0.63 cm3 (standard deviation = 0.31) in the control group (P < .0001).
CONCLUSIONS: Results of this study demonstrate a higher choroid plexus volume in patients with SIH with spinal CSF leak compared with age- and sex-matched healthy controls. This likely reflects compensatory mechanisms to counteract intracranial hypotension by increasing CSF production as well as increased vascularity of the choroid plexus through expansion of the intracranial blood pool.
Subjects will game for 2 hours sitting and take a 6 minute walking break at the one hour period before resuming game play. All subjects will undergo blood flow assessments before and after taking an active break (i.e. 6-minute walk) during their gaming session.