anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cholangiocarcinoma (CCA) displays enhanced glycolysis, pivotal for fulfilling the heightened energy demands intrinsic to its malignant progression. Recent research has indicated that endogenous glycogen rather than exogenous glucose acts as the major carbon source for glycolysis, highlighting the need to better understand the regulation of glycogen homeostasis in CCA. Here, through comprehensive integrative analysis, we identified that glycogen phosphorylase brain form (PYGB), the main enzyme involved in glycogen homeostasis, was markedly upregulated in CCA tissues, serving as an independent prognostic indicator for human patients with CCA. Moreover, elevated PYGB expression potentiated cholangiocarcinogenesis and augmented CCA cell proliferation in both organoid and xenograft models. Hypoxia stimulated PYGB activity in a phosphoglycerate kinase 1-dependent manner, leading to glycogenolysis and the subsequent release of glucose-6-phosphate (G6P) and thereby facilitating aerobic glycolysis. Notably, a virtual screening pinpointed the β-blocker carvedilol as a potent pharmacologic inhibitor of PYGB that could attenuate CCA progression. Collectively, these findings position PYGB as a promising prognostic biomarker and therapeutic target for CCA.  Significance: Cholangiocarcinoma cells exhibit high glycogen phosphorylase activity under hypoxic conditions that mediates metabolic reprograming to promote glycolysis and support tumor development.
Twenty-five participants will complete five weeks of heart rate variability biofeedback using emWave software (HeartMath®Institute, 2020). Participants will receive a weekly 30-minute heart rate variability biofeedback session for five weeks at the University Parkway Center, Brigham Young University. The heart rate variability biofeedback protocol will be based on Lehrer et al., 2013 and Yoo et al., 2022. This format will aid participants in implementing and learning breathing and heart rate variability biofeedback skills (Lehrer et al., 2020). All participants will wear an ear sensor to measure their pulse. The heart rate variability biofeedback will focus on autonomic balance through slow breathing at a resonance frequency of approximately 6 breathes per minute. The best approximate breathing pace for resonance frequency will be estimated and participant's resonance frequency will be provided and used for their homework and subsequent training sessions.
The invention provides a fresh garlic volatilizing agent. The volatilizing agent is prepared from the following raw materials in parts by weight: trichosanthes kirilowii maxim, apricot kernels, fritillaria cirrhosa, roasted flos farfarae, dendranthema morifolium and ammonium salt. The richosanthes kirilowii maxim, apricot kernels, fritillaria cirrhosa, roasted flos farfarae and dendranthema morifolium are aired and powdered, and are uniformly mixed with the ammonium salt according to the proportion. The volatilizing agent further comprises trollius chinensis bunge, cauda equina and platycodon grandiflorum. The fresh garlic volatilizing agent with a simple formula is mixed with mashed garlic to reduce the irritation of garlic gas, and enables quick and efficient release of garlic molecules, so that the utilization rate of garlic is improved; and the released garlic gas directly acts on the lung of a human body to achieve a good treatment effect on pulmonary diseases and a good assistant treatment effect on tumors. The fresh garlic volatilizing agent is especially suitable for old people and children.
PURPOSE:To obtain albumin in high purity and in high yield from a protein solution containing albumin derived from human plasma, by heat-treating the solution under a specific condition. CONSTITUTION:A protein solution containing albumin derived from human plasma, especially from alpha- and beta-globulin fraction is adjusted in 0.5-3W/V% protein concentration in the presence of 3-10mM organic acid having 3-10C or a salt thereof (e.g. butyric acid, caprylic acid, mandelic acid, etc.) and 1-10W/V% ammonium sulfate to pH 4.5-5.5, preferably pH 4.9-5.4, more preferably pH 5.0-5.3 and heat-treated at 65-70 deg.C, preferably at 68 deg.C for 15-60min, preferably 30min. After the heat treatment, the solution is cooled to 10-20 deg.C, filtered, centrifuged (5,000-15,000rpm for 10-30min) and the supernatant liquid is recovered to give albumin. Consequently high-quality albumin preparation is obtained and this method can be applied to treatment of crude albumin fraction having undergone ammonium sulfate fraction treatment.
Misophonia is a condition characterized by intense affective and/or physical responses to auditory triggers. Negative affective states, including significant distress and avoidance are characteristic of misophonia. These negative emotional responses to trigger sounds, which result in behavioral problems and impairment, may be the primary targets for effective psychosocial intervention for misophonia. Transdiagnostic treatment approaches address clinically-significant distress through the use of evidence-based, cognitive-behavioral techniques (e.g., mindful awareness, problem-solving, and opposite action strategies) that allow for flexible and personalized treatment of core dysfunctions that cut across emotional disorders and lead to on-going impairment. This type of evidence-based, transdiagnostic approach includes skills applicable for problems observed frequently in misophonia including adaptability, problem solving, emotional (arousal) dysregulation and poor distress tolerance. The hypothesized mechanism of change of these core-dysfunction focused treatments is increased tolerance of distress in response to strong or intense emotion states. A secondary target is the reduction of maladaptive emotional behaviors (e.g., avoidance, aggression, escape) that may reinforce distress over time. To that end, this proposal aims to evaluate the feasibility and preliminary efficacy of the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) for youth with misophonia. We will compare UP-C/A in a 2:1 ratio against a comparison condition (PRT: psychoeducation plus relaxation training), a behavioral approach that represents usual treatment in the community and has been utilized in clinical trials (35% response rate).
The Wellness Lifestyle Program (WLP) is a comprehensive lifestyle program that consists of 30 minutes of educational information covering various topics, such as nutrition, healthy living, stress reduction, and more will be followed by 30 minutes of low-intensity exercise such as walking. The duration of the intervention will be 12 months. Participants will engage in the 60 minute WLP session twice a week for the first 12 weeks (3 months) of the project. The following 12 weeks, participants will engage in WLP sessions once a week. The remainder of the study (6 months), participants will engage in WLP sessions once a month.
Umbilical cord care will be carried out using soap at least 3 times a day. Firstly, there must be a proper hand hygiene. Then, with sterile gauzes alcohol will be applied from the abdominal part to the end of the stump.
PURPOSE:To obtain an anti-inflammatory agent having high safety and activity, easily, by extracting and purifying a thiol protease inhibitor from human urine using a combination of two or more extraction means such as molecular filter, ion exchange material, adsorbent, etc., and using the purified substance as an active component. CONSTITUTION:A thiol protease inhibitor is extracted and purified from human urine by a combination of two or more extraction means selected from molecular filter (e.g. sephadex), ion exchange material (e.g. DEAE-cellulose), adsorbent (e.g. hydroxyapatide) and affinity chromatography (e.g. trypsine-sephalose). The obtaind inhibitor improves the inflammation caused by thiol protease, and is also useful as a remedy for muscular dystrophy and renal hypertension in which thiol protease is participated. The extraction and purification can be carried out by a relatively simple process, and the method can be applied to mass production. There is no problem of antigenicity.
This disclosure provides a protein oleogel comprising plant protein dispersed in a liquid oil phase. The oleogel has a microstructure in the form of fibrils, sheets, or other particles with a high aspect ratio that are substantially not interconnected. It can be manufactured by a process that includes solubilizing and denaturing the protein in an aqueous liquid, flash freezing and drying the protein, and then gradually and gently adding a suitable oil or oil mixture. The protein microstructure releases some but not all of the oil when heated. The oleogel forms a spreadable emulsion in an aqueous liquid that is stable for at least six weeks without evidence of creaming. The oleogel may substitute for oils and fats of animal origin in food, food ingredients, cosmetics, and personal care products. This lessens the impact of food manufacturing on the environment, which helps mitigate climate change.
PURPOSE:To provide the title instillation containing an isoquinolinone derivative and, as stabilizer, a phenolic hydroxyl group-contg. compound and/or glycol. CONSTITUTION:The objective instillation can be obtained by dissolving in an appropriate base (A) as active ingredient, an isoquinolinone derivative of the formula (R1 is H or lower alkyl; R2 is lower alkyl) or its acid-added salt so as to be 0. 1-5w/v% in the content and (B) as stabilizer, a phenolic hydroxyl group-contg. compound (e. g. phenol) and/or glycol so as to be 0. 02-10w/v% in the content, followed by sterilization treatment. The present instillation can be additionally incorporated with such ingredient(s) as dissolution aid, thickening agent, buffering agent, antioxidant or preservative. For the present instillation, 0. 005-2.5mg per adult/day of the active ingredient should be administered once or in several portions a day.
OBJECTIVES: Severe deficiency of growth hormone (GHD) of the newborn is a rare but potentially life-threatening disease. GH measured during the first week of life, using dried blood spots (DBS), may offer several advantages. Aim of the study was to estimate the reference values for GH in newborns by a new analytical method using DBS.
METHODS: Using a new developed analytical method, GH was estimated from DBS of 1,036 healthy newborns attending the Neonatology Unit of Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico of Milan in the period July-October 2021. Reference values for GH deficiency were estimated by the Harrell-Davis bootstrap method, with 90 %CI calculated by the bias-corrected and accelerated bootstrap method.
RESULTS: All GH measurements required 33 analytical sessions (8 months) with a CV% for calibration curve slopes equal to 6.9 %. Intermediate precision evaluated by measurement of low (3 μg/L) and high (10 μg/L) quality controls was, respectively, 14 and 6.5 %. GH reference values, estimated at percentiles 1.0st, 2.5th and 5.0th, and their 90 %CI, were, respectively, 4.5 μg/L (90 %CI 3.8-5.1), 5.9 μg/L (90 %CI 5.4-6.4) and 7.0 μg/L (90 %CI 6.7-7.3). GH levels were not associated with sex, standard deviation scores, birth weight, gestational age, type of delivery or mother's variables (age, smoking habit, gestational diabetes).
CONCLUSIONS: Validation data suggest that this method can be used to measured GH in newborns using DBS. The reference values estimated in this study are in accordance with previous published works using ELISA and may help confirming the clinical suspicion of neonatal GHD.
Cricket fast bowlers require a unique blend of speed, strength, power, and agility to excel in their role on the field. In recent years, Complex training has emerged as a popular training method to enhance these critical qualities among fast bowlers. Complex training involves combining strength exercises with explosive, sport-specific movements in a single training session, aiming to improve overall athletic performance. This study will be a randomized controlled trial and the data will be collected from National Cricket Academy and domestic cricket clubs. The sample size will be calculated by conducting a pilot study. There will be three groups. Group-A will be receiving Complex training, Group-B will be receiving Conventional training and Group C as a Control Group. Athletes with same physical fitness level will be recruited. There will be parallel assignment of the participants. Assessor will be kept blinded. All the parameters would be assessed at Baseline, 6 Weeks, 12 Weeks. Physical fitness will be assessed through Field Testing. Bowling performance will be assessed through speed machine and Kinovea Software. Work capacity will be assessed through step testing. Muscle strength will be assessed through Dynamometer. Lastly, BMD will be assessed though Bone Densitometer.
Case presentation: Scientific documentation on lifelong repeated cycles of long-term fasting doesn't exist. We report the case of a 92-year-old man who fasted 3 weeks yearly for 45 years. Results: Body weight and clinical parameters showed cyclic variations, returning to baseline after food reintroduction. Biological age analysis indicated that the patient was 5.9 years younger than his chronological age. Mental and physical health tests documented the absence of frailty, that the patient could function independently, had excellent cognitive functions, and a good mobility. Conclusion: It can be reasonably assumed that this subject have had protective effects from his yearly fasting.
BACKGROUND: Work-related pain is a known risk factor for vascular surgeon burnout. It risks early attrition from our workforce and is a recognized threat to the specialty. Our study aimed to understand whether work-related pain similarly contributed to vascular surgery trainee well-being.
METHODS: A confidential, voluntary survey was administered after the 2022 Vascular Surgery In-Service Examination to trainees in all Accreditation Council for Graduate Medical Education-accredited vascular surgery programs. Burnout was measured by a modified, abbreviated Maslach Burnout Inventory; pain after a full day of work was measured using a 10-point Likert scale and then dichotomized as "no to mild pain" (0-2) vs "moderate to severe pain" (3-9). Univariable analyses and multivariable regression assessed associations of pain with well-being indicators (eg, burnout, thoughts of attrition, and thoughts of career change). Pain management strategies were included as additional covariables in our study.
RESULTS: We included 527 trainees who completed the survey (82.2% response rate); 38% reported moderate to severe pain after a full day of work, of whom 73.6% reported using ergonomic adjustments and 67.0% used over-the-counter medications. Significantly more women reported moderate to severe pain than men (44.3% vs 34.5%; P < .01). After adjusting for gender, training level, race/ethnicity, mistreatment, and dissatisfaction with operative autonomy, moderate-to-severe pain (odds ratio, 2.52; 95% confidence interval, 1.48-4.26) and using physiotherapy as pain management (odds ratio, 3.06; 95% confidence interval, 1.02-9.14) were risk factors for burnout. Moderate to severe pain was not a risk factor for thoughts of attrition or career change after adjustment.
CONCLUSIONS: Physical pain is prevalent among vascular surgery trainees and represents a risk factor for trainee burnout. Programs should consider mitigating this occupational hazard by offering ergonomic education and adjuncts, such as posture awareness and microbreaks during surgery, early and throughout training.
Patients will receive doses of vaccine at 2 week intervals for 5 doses and at 4 week intervals for doses 6-16. The injection will be performed subcutaneously in the deltoid region of the upper arm.
PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity capable of manifesting antiseptic effects sufficient to prevent the secondary contamination and having low irritation by blending a propolis extract in the composition for the oral cavity containing an irritating antiseptic agent. SOLUTION: This composition for the oral cavity is obtained by blending a propolis extract and a preservation agent. The composition for the oral cavity is used as a dentifrice composition such as a toothpaste and a powder dentifrice, a paste for the oral cavity, a troche agent, a mouth wash, etc. The propolis extract is an extract of a gum-like material gathered and produced by honeybees from a plant, by an organic solvent. The blending percentage of the propolis extract is preferably 0.1-10wt.% and the one of preservation agent is preferably 0.01-0.5wt.%. A low irritation is accomplished thereby and also the composition manifests an excellent antiseptic efficacy against the secondary contamination of microbes.
The Health Living Program (HeLP) is a manualized community-delivered program tailored specifically for Latino families and children at-risk for adult obesity. HeLP includes 6 weekly 2-hour nutrition/cooking sessions and 6 weekly 2-hour Multidisciplinary Sessions, that include parent education on nutrition, fitness, goal-setting, and parenting, a teen group physical fitness class, and a teen health knowledge curriculum derived from a health education curriculum called Hey DURHAM.
ABSTRACT OF THE DISCLOSURE         There is disclosed a system and apparatus for purifying a fluid stream which employ a fixed ligand to absorb a ligate carried in the fluid stream.  The system and apparatus each includes a bed of ligands affixed to a semipermeable membrane.  The ligand has a binding constant which, in the environment normally present in the fluid stream, will predictably bind the ligate and thus remove it from the fluid stream.  An agent which regenerates the ligand is conveyed to the ligand bed by diffusion across the semi-permeable membrane.  The diffused agent breaks the ligate-ligand bond.  The ligand is regenerated for subsequent use, and the ligate is freed for disposal.
The work is one-armed. It consists of only those in the intervention group. After the study was announced, informed consent was obtained from those who agreed to participate in the study. Afterwards, the participants filled out the Demographic Data Form, Repetitive Behavior Scale-Revised (RBS-R), Social Communication Checklist-Revised (SCC-R), Child Behavior Checklist-Dysregulation Profile (CBCL-DP) forms before the intervention program started. When the 8-week online group-based parent mediated intervention program was over, they filled out formsRepetitive Behavior Scale-Revised (RBS-R), Social Communication Checklist-Revised (SCC-R), Child Behavior Checklist-Dysregulation Profile (CBCL-DP) again in the first week.
Subjects in this arm will consume a placebo twice daily for four weeks, mixed into their food/drink. This is followed by four weeks of 500mg sodium propionate powder, twice daily.
PURPOSE:To obtain a medicine capable of sufficiently inhibiting the excessive response of a living body causing allergic diseases and autoimmune diseases. CONSTITUTION:This agent for inhibiting the excessive response of a human body contains a Chinese medicine having a blood-activating action as an active ingredient preferably in an amount of 1-50wt.%, especially 5-30wt.%. The Chinese medicine includes Ligusticum wallichii, Salvia miltiorrhiza, Millettia reticulata, Irex pubescens Hook. et Arn. Corydalis bulbosa DC., Curcuma aromatica Salisb., Curcuma longa L., Lconurus heterophillus Sweet, Leonurus heterophillus Sweet, Lycopus lucidus Turcz, Camsis gradiflora (Thunb.) Loisei, natural copper, Daemonorops draco Bl., Caesalpinia sappan L., Impatiens balsamina L., Petaurista xanthotis Milne-Edwards, Area granosa L., Manispentadactyla L., Whitmania pigra Whitman, Eupolyphaga sinensis Walk., Naemorhedusgoral Hardwicke, Bas taurusdomesticus Gmelin, and the like. The inhibiting agent is effective for the therapy or preventive therapy of allergic diseases such as pollinosis, hay fever, atopic dermatitis and delayed contact dermatitis, and autoimmune diseases such as systemic lupus erythematosus, periarteritis nodosa, scleroderma, dermatomyositis and chronic articular rheumatism.
The specific objectives of this study are to determine the change in the following indicators during the course of the TIPTOP project: 1) Proportion of women who have had a pregnancy that ended in the past 12 months and have received 1 or more, 2 or more and 3 or more doses of IPTp-SP; proportion of women with pregnancy in the past 12 months who attended ANC clinics at least once, and who attended at least four times; proportion of pregnant women attending the first ANC visit before or at week 14; proportion of women who have had a pregnancy that ended in the past 12 months who know about the IPTp service provided by CHWs; and acceptability of C-IPTp for community delivery of IPTp (note: results will be disaggregated by provider type, age, gravidity and distance from facility). To assess these changes, the study will implement structured household surveys targeting potential beneficiaries of the project (pregnant women) in the intervention and comparison areas, implemented at three time points: baseline, mid- and end-points. In each country an initial implementation area (Phase I) and two expansion areas (Phase II) have been selected for the project. This study will establish if community deliver of IPTp is effective and feasible and whether it influences antenatal care service coverage rates. It is expected that the study will provide information to scale up the approach the 4 study countries for the prevention of malaria in pregnancy. This information is also meant to inform global guidelines on community IPTp delivery and may also be used by other countries.
This arm will receive two 20-minutes sessions of NET 1 week apart. NET (Neuro Emotional Technique) is a non-invasive stress reduction technique.
Patients randomized to the intervention group will be equipped with a real-time CGM sensor (Dexcom G6 sensor, a small flexible device that records interstitial glucose levels every five minutes). The sensor will be inserted into the subcutaneous tissue of the anterior abdomen wall. Additionally, patients will be advised to record capillary blood glucose values if glucose alerts or readings do not match with symptoms or expectations. Participants will be educated how to exchange the sensor (has to be exchanged every ten days) and will be equipped with a real-time CGM monitor and instructed in its use. The monitor provides the user with information about current glucose levels and notifies the patient before she reaches her upper or lower glucose threshold and when glucose levels change rapidly. All patients in the intervention group will specifically trained how to use the system.