anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A line-interactive single conversion uninterruptible power supply (UPS) utilizing a multiple tapped ferroresonant transformer and a square wave PWM inverter is presented. During normal utility line operation, the line voltage is not modified in any way, except for ferroresonant filtering and regulation. Tap control circuitry insures proper tap selection based on the utility input voltage. During tap transitions in utility out of specification operation, a second power source, such as an inverter, is operated to provide output power to the connected loads. The control of the inverter switching angles may be accomplished through a look-up table. This look-up table contains the converter pulse widths for monitored battery voltage. No output voltage feedback is required. Based on the inherent regulation provided by the ferroresonant transformer, the PWM control may be accomplished in course steps.
The device has a terminal (1) with a reading unit for reading drug and patient data, an input unit e.g. touchscreen, a display and a computer. An internet connector (7) is provided between the computer of the terminal and a server (5). Data communication connections (8, 9) are provided between the computer of the terminal and another server (6). The latter server has direct data lines (12) in computers in pharmacies (10, 11), and drug and patient data are stored on the latter server or directly sent, where the data is displayed, processed and printed in the selected pharmacy. An independent claim is also included for a method for purchasing drugs.
The use of dry needling is becoming widely used by Physical Therapists in the United States for a number of neuromusculoskeletal conditions including cervicogenic headache (CGH). Dry needling is performed by taking a mono-filament needle and inserting it into symptomatic soft tissue. In this trial, the dry needling will be performed segmentally in the neck and along the patient's headache distribution pattern. Orthopedic manual therapy (OMT) may include both thrust and non-thrust techniques applied to a targeted spinal level and has a well-established treatment effect for patients with CGH. In this trial, the OMT will be applied pragmatically to the cervical spine at the most symptomatic level of the headache. Other interventions used in this trial will include patient education, thoracic manipulation and exercise.

Patients will be randomized to receive either dry needling or OMT 2x/week for 2 weeks and then 1-2x/week for 2 weeks totaling 6-8 visits over the course of 1 month. The 1 week and 1 month outcomes collected will be reported on separately from the 3 and 12 months.
PROBLEM TO BE SOLVED: To obtain the subject composition useful for cancer treatment, by including an antibody consisting of an antigen-binding region of an antibody recognizing a cancer-specific mucin, and an constant region of an antibody of human origin as an active component. SOLUTION: This pharmaceutical composition useful for treatment of cancer, especially, pancreatic cancer, is obtained by including an antibody consisting of (A) an antigen-binding region of an antibody recognizing a cancer-specific mucin expressed in cancerous tissues (e.g. antigen-binding region of a mouse Nd2 monoclonal antibody recognizing pancreatic cancer-specific mucin, etc.), and (B) an constant region of an antibody, belonging to IgGl, of human origin (e.g. mouse-human chimera Nd2 monoclonal antibody, etc.), as an active component. The objective pharmaceutical composition can be administered by, e.g. intravascular, intraperitoneal, subcutaneous or intramuscular injection. A daily dose of this composition in human is preferably about 1-100 mg as antibody quantity.
This study explores the genetic risk associations with autism spectrum disorder (ASD) using graph neural networks (GNNs), leveraging the Sfari dataset and protein interaction network (PIN) data. We built a gene network with genes as nodes, chromosome band location as node features, and gene interactions as edges. Graph models were employed to classify the autism risk associated with newly introduced genes (test set). Three classification tasks were undertaken to test the ability of our models: binary risk association, multi-class risk association, and syndromic gene association. We tested graph convolutional networks, Graph Sage, graph transformer, and Multi-Layer Perceptron (Baseline) architectures on this problem. The Graph Sage model consistently outperformed the other models, showcasing its utility in classifying ASD-related genes. Our ablation studies show that the chromosome band location and protein interactions contain useful information for this problem. The models achieved 85.80% accuracy on the binary risk classification, 81.68% accuracy on the multi-class risk classification, and 90.22% on the syndromic classification.
PURPOSE: An antibacterial composition which is prepared using plants is provided to ensure excellent antibacterial activity with safety and fewer side effects and to be used in pharmaceutical products, cleaning agents, or cosmetic materials. CONSTITUTION: An antibacterial pharmaceutical composition contains a light-irradiated material of a plant extract or a fraction of the extract, which is prepared from a plant selected from the group consisting of Euphorbia supina, Paulownia coreana Uyeki, Ranunculus sceleratus, Ficus carica L., Pueraria thunbergiana, Apios americana Medikus, Catalpa ovata, Angelica tenuissima, Illicium religiosum, Phytolacca esculenta, Pteridium aquilinum var. latiusculum, Lythrum anceps, Juglans sinensis, Sophora japonica L., Kalopanax pictus, and Orostachys japonica (Maxim.) A. Berger. An antibacterial cleaning agent contains the light-irradiated material as an active ingredient. The light is irradiated at 2,000-18,000 lux for 1-24 hours.
Stress substantially increases the risk of developing painful temporomandibular disorders (TMDs) by influencing the release of endogenous catecholamines. Propranolol, an antagonist of β-adrenergic receptors, has shown potential in alleviating TMD-associated pain, particularly when the level of catecholamines is elevated. The aim of this study was to explore whether intra-articular propranolol administration is effective in diminishing temporomandibular joint (TMJ) pain during repeated stress situations. Additionally, we investigated the effect of repeated stress on the expression of genes encoding β-adrenoceptors in the trigeminal ganglion. In the present study, rats were exposed to a stress protocol induced by sound, then to the administration of formalin in the TMJ (to elicit a nociceptive response), followed immediately afterward by different doses of propranolol, after which the analgesic response to propranolol was evaluated. We also assessed the levels of beta-1 and beta-2 adrenergic receptor mRNAs (Adrb1 and Adrb2, respectively) using reverse transcription-quantitative PCR (RT-qPCR). Our findings revealed that propranolol administration reduces formalin-induced TMJ nociception more effectively in stressed rats than in non-stressed rats. Furthermore, repeated stress decreases the expression of the Adrb2 gene within the trigeminal ganglion. The findings of this study are noteworthy as they suggest that individuals with a chronic stress history might find potential benefits from β-blockers in TMD treatment.
During the 12 weeks of the internship, the experimental group took a pre-test after a case report-1 in weeks 4-5, which included completing the holistic thinking case analysis form and the personal learning self-efficacy questionnaire, followed by a 2-hour structured holistic thinking course. At the end of the session, subjects took the first post-test, revised the case analysis form completed in the pre-test based on the case report-1 observed in the pre-test, and completed the personal learning self-efficacy questionnaire and the satisfaction questionnaire again. During weeks 6-11 of the internship, participants continue to receive clinical practice training in assessment, intervention planning, and patient intervention skills. In weeks 11-12 of the internship, subjects took a second post-test after reading case report-2, which included completing the holistic thinking case analysis form and again completing the personal learning self-efficacy questionnaire.
Participants in the sequential condition will increase F/V consumption and decrease Sed behavior (weeks 1-6), then increase physical activity (weeks 7-12). Smartphones are equipped with customized real-time goal thermometers that provide objective feedback on target behaviors (FV, Sed, and PA). At the start of prescription, the FV and Sed goal thermometers are activated. During week 1-2, participants will close 1/3 of the gap between their baseline behaviors and target behaviors. During week 3-4 they will close 2/3 of the gap, and in weeks 5-6 they will achieve 100% of their goals. Participants will maintain these goals for the remainder of the 12-week intervention. At week 7, a real-time PA goal thermometer wirelessly linked to accelerometers will be activated. Similarly, in weeks 7-8 participants will be asked to close 1/3 of the gap between their baseline PA and target, in week 9-10 they will close 2/3 of the gap, and finally they will reach 100% of their PA goal in weeks 11-12.
The invention discloses an external Chinese herbal medicine composite for simply treating phalacrosis. The Chinese herbal medicine composite consists of drugs with the following weight proportions: 100-120 grains of sheep feces, 140-160g of white stone flower, and 40-60ml of benne oil. The thought of medicinal compatibility of the invention is taking the sheep feces as the most important component, followed by the white stone flower and the benne oil. The invention is the external Chinese herbal medicine composite for simply treating phalacrosis. The raw materials thereof are easy to find, the preparation method is simple, the use is convenient, the using effect is particularly obvious. Normally, after using the medicine for 5 to 6 times, hairs of the patients with phalacrosis begin to grow; and after using the medicine for 8 to 10 times, the patients can recover.
Study patients assigned to this arm will use PreviDent 5000 plus or Tom's of Maine Children's (age 6 years and younger) toothpaste for daily teeth brushing from day 1 to day 14. Study participants will be encouraged to continue use study toothpaste and monitored up to 44 days after study enrollment.
Unexplained euploid embryo transfer failure (UEETF) is a frustrating and unanswered conundrum accounting for 30 to 50% of failures in in vitro fertilization using preimplantation genetic testing for aneuploidy (PGT-A). Endometriosis is thought by many to account for most of such losses and menstrual suppression or surgery prior to the next transfer has been reported to be beneficial. In this study, we performed endometrial biopsy in a subset of women with UEETF, testing for the oncogene BCL6 and the histone deacetylase SIRT1. We compared 205 PGT-A cycles outcomes and provide those results following treatment with GnRH agonist versus controls (no treatment). Based on these and previous promising results, we next performed a pilot randomized controlled trial comparing the orally active GnRH antagonist, elagolix, to oral contraceptive pill (OCP) suppression for 2 months before the next euploid embryo transfer, and monitored inflammation and miRNA expression in blood, before and after treatment. These studies support a role for endometriosis in UEETF and suggest that medical suppression of suspected disease with GnRH antagonist prior to the next transfer could improve success rates and address underlying inflammatory and epigenetic changes associated with UEETF.
BACKGROUND AND PURPOSE: The interleukin (IL)-36 pathway is a critical player in the pathogenesis of pustular psoriasis. However, therapies targeting this pathway are limited or unaffordable (e.g. the anti-IL-36 receptor antibody). AMP-activated protein kinase (AMPK), a regulator of cellular energy and metabolism, is known to participate in inflammatory diseases. However, its role in IL-36-induced skin inflammation remains unclear. Therefore, we sought to investigate the role of AMPK signals in regulating IL-36-induced responses in the skin.
EXPERIMENTAL APPROACH: IL-36-stimulated primary normal human epidermal keratinocytes (NHEKs) and IL-36-injected (intradermally) BALB/c mice served as the cell and animal models, respectively. Additionally, 5-aminoimidazole-4-carboxamide riboside (AICAR) and A769662 served as AMPK activators.
KEY RESULTS: AICAR and A769662 significantly suppressed the IL-36-induced IL-8 (CXCL8) and CCL20 production from NHEKs. IL-36-induced IκBζ protein expression was prominently reduced and IKK/IκBα phosphorylation was attenuated by AICAR and A769662. Conversely, AMPKα knockdown increased IκBζ protein expression and IKK/IκBα phosphorylation in IL-36-treated NHEKs. Furthermore, AICAR and A769662 enhanced IL-36-induced-IκBζ protein degradation via the proteasome-dependent but not the lysosome-dependent pathway. Pretreatment of NHEKs with IL-36 slightly suppressed the AICAR- and A769662-triggered phosphorylation of AMPK and acetyl-CoA carboxylase. In the mouse model, topical application of AICAR significantly reduced ear swelling, redness, epidermal thickening, neutrophil infiltration and inflammatory and antimicrobial peptide gene expression.
CONCLUSION AND IMPLICATIONS: AMPK activation suppresses IL-36-induced IL-8 and CCL20 release by regulating IκBζ expression in keratinocytes and reduces IL-36-induced skin inflammation in mice, suggesting that AMPK activation is a potential strategy for treating patients with IL-36-mediated inflammatory skin disorders.
The World Health Organization (WHO) defines the stroke as a brain injury that causes rapid and noticeable changes in cerebral function, lasting 24 hours or longer, or resulting in death. Strokes can be caused by vascular issues and include cerebral infarction, intracerebral hemorrhage, and subarachnoid hemorrhage. Stroke is a syndrome characterized by acute neurological deficits caused by vascular injury in the central nervous system. It's a major cause of disability and mortality globally, resulting from various risk factors, diseases, and mechanisms. Dual-task training refers to the ability to simultaneously perform multiple cognitive and motor activities while maintaining postural control. Divided attention is the capacity to do more than one thing at the same time. Dual-task training innovatively combines motor and cognitive rehabilitation in a comprehensive module. TST, or task-specific training, is a popular rehab approach that emphasizes function and is commonly used for stroke patients. It's all about targeting specific tasks to help with recovery.

RCT conducted on two groups, Dual Task Training and Task Specific training. interventions applied with a frequency of three times a week for eight weeks protocol. Participants will be divided into 2 groups. 1st group will receive Dual task training for motor and cognition simultaneously. 2nd group will receive task specific training for motor and cognition functioning.
PURPOSE: The purpose of this therapeutic update is to provide pharmacists with a general overview of the pathophysiology of hyperchloremia and describe strategies to help prevent development of this electrolyte abnormality in hospitalized patients.
SUMMARY: Hyperchloremia is an electrolyte abnormality associated with an increased incidence of acute kidney injury and metabolic acidosis. Intravenous (IV) fluids utilized for volume resuscitation, medication diluents, and total parental nutrition all may contribute to the development of hyperchloremia. Current evidence suggests that administration of balanced crystalloids for either fluid resuscitation or maintenance fluids may impact serum chloride levels and patient outcomes. In multiple randomized controlled trials, administering balanced crystalloids for fluid resuscitation in critically ill patient populations did not decrease mortality. However, further analyses of subpopulations within these trials have demonstrated that patients with sepsis may benefit from receiving balanced crystalloids for initial fluid resuscitation. Results from several small studies suggest that altering the composition of these IV fluids may help prevent development of hyperchloremia.
CONCLUSION: Management of hyperchloremia is preventative in nature and can be mitigated through management of resuscitation fluids, medication diluents, and total parenteral nutrition. Inpatient pharmacists should be aware of the potential risk of fluid-associated hyperchloremia and assist with optimal fluid management to prevent and manage hyperchloremia.
1385086 Insulin complexes ELI LILLY & CO 28 April 1972 [30 April 1971] 19741/72 Heading A5B Insulin salt-protamine complexes containing an alkali metal e.g. sodium, potassium, lithium or caesium, or ammonium salt of insulin and from 0.2 mg to 1.5 mg of protamine for each 100 units of insulin have a rapid onset and a prolonged duration of hypoglycaemic action. A suspension of the complex in an aqueous medium e.g. water or an isotonic solution is prepared by combining in an aqueous medium protamine and an alkali metal or ammonium salt of insulin in proportions so that for each 100 units of insulin there is present from 0.2 to 1.5 mg of protamine. The insoluble complex may be separated from the aqueous medium and the moisture content thereof reduced to less than 10% by weight. The alkali metal salt of insulin may be prepared by subjecting crude insulin to treatment in the presence of alkali metal ions e.g. from an alkali metal hydroxide to effect crystallization of the salt.
###  Risk Summary

The Centers for Disease Control and Prevention recommend that HIV-1 infected mothers in the United States not breastfeed their infants to avoid risking postnatal transmission of HIV-1 infection. Published data report that nevirapine is present in human milk [see Data]. There are limited data on the effects of nevirapine on the breastfed infant. There is no information on the effects of nevirapine on milk production. Because of the potential for (1) HIV-1 transmission (in HIV-negative infants), (2) developing viral resistance (in HIV-positive infants), and (3) serious adverse reactions in nursing infants, mothers should not breastfeed if they are receiving nevirapine. 

###  Data

Based on five publications, immediate-release nevirapine was excreted in breast milk at median concentrations ranging from 4080 to 6795 ng/mL, and the median maternal breast milk to maternal plasma concentration ratio range was 59 to 88%. Reported infant nevirapine median plasma concentrations were low, ranging from 734 to 1140 ng/mL. The estimated nevirapine dose of 704 to 682 mcg/kg/day for infants fed exclusively with breast milk was lower than the daily recommended nevirapine dose for infants. Published literature indicates that rash and hyperbilirubinemia have been seen in infants exposed to nevirapine through breastmilk.
The overarching goal of the proposed research is to learn how to optimize group-based psychological treatments for chronic pain delivered over video telehealth to the homes of older Veterans. Chronic pain is a critical healthcare challenge for VA, because the condition affects 50% of Veterans and is notoriously difficult to treat. Older Veterans are affected with chronic pain even more commonly and severely than younger Veterans, and older Veterans are more susceptible to side effects from pain medications and invasive procedures. Psychological chronic pain treatments do not usually have severe side effects, but tend to produce only modest benefits. To increase the effectiveness of psychological treatments, VA experts have recommended testing standardized treatments with larger and more durable benefits, testing group and video telehealth delivered treatments to improve access, identifying mechanisms of response so that the most powerful mechanisms may be targeted, and determining what Veteran characteristics may predict response to the various treatment options. The proposed randomized clinical trial will address all the recommendation of VA experts. First, the project will evaluate the effects of standardized formats of Mindfulness Meditation (MM) and Emotional Awareness and Expression Therapy (EAET) compared to the VA standard psychological chronic pain treatment, Cognitive Behavioral Therapy (CBT). Many Veterans are interested in MM, but a standardized protocol so far has not been established. EAET is a newer treatment that addresses painful stress and emotions to reduce or eliminate chronic pain. These two approaches are hypothesized to have larger benefits than CBT. Second, the project will deliver all treatments in groups and over video telehealth to the homes of Veterans to enhance access. Third, the project will test shared and specific (unique) mechanisms of response for each treatment. Fourth, the project will evaluate a set of demographic and clinical characteristics (e.g., trauma history) to see whether Veterans with certain characteristics are more likely to respond to one treatment or another. The Investigators plan to enroll up to 216 multi-ethnic/multi-racial older Veterans (age 60-95 years) with chronic musculoskeletal pain at VA Greater Los Angeles Healthcare System and VA Connecticut Healthcare System.
Camomile with high chamazulene and bisabolol content is produced from chamomile varity H-29. The chamomile flower heads are pref. harvested at the stage of growth at which only 50% of the tubular florets have opened, the harvested flower heads being dried at an air temp. of not >50 degrees C. The antiinflammatory activity of camomile is attributable to chamazulene and (-)-alpha-bisabolol. Normally, high chamazulene concns. are accompanied by low bisabolol concn. and vice-versa. Surprisingly, chamomile (Matricaria chamomilla) variety H-29 (endemic in the Lerida province of Spain) has high content of both chamazulene and bisabolol, and is partic. suitable for camomile prodn.
The present invention relates to slow-release 5-aminosalicylic acid in a magnetic supermolecule intercalation structure and a preparing method thereof. The present invention uses spinel NFe2O4 as a magnetic ingredient, an anionic-layer-shaped material LDHs as a main body, and the 5-aminosalicylic acid as an intercalation guest body. Spinel nano powder is added into a soluble mixed salt solution containing divalent and trivalent metal ions, and the mixture of the spinel nano powder and the soluble mixed salt solution is treated with intercalation assembly with an alkali solution containing the 5-aminosalicylic acid to obtain a supermolecular structure 5-ASA-LDHs/NFe2O4. The magnetic 5-aminosalicylic acid slow-release agent is composed of a putamen-type structure, which is that a coating-shaped material 5-ASA-LDHs is wrapped outside NFe2O4 nanometer particles. The specific saturation magnetized strength of the NFe2O4 nanometer particles is from 1.0 to 4.0 emu/g, and the particle size is about 25 to 120 nm. The present invention provides magnetism to the medicine. The medicine can target a focus part under the guidance of outer magnetism. The treating time can be shortened, and the treating effect can be improved.