anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: There is limited study that illuminates the relationship between obesity indices and prognosis in patients with heart failure with preserved ejection fraction, nor has it been examined whether the obesity paradox persists when using these metrics.
METHODS AND RESULTS: This study is a post hoc analysis of data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. A total of 3114 individuals were included in our final analysis, and a total of 481 (15.4%) all-cause deaths, and 389 (12.5%) heart failure hospitalizations were recorded. In a multivariable Cox regression model, compared with patients with a body mass index (BMI) <24.9 kg/m2, those with a BMI of 25.0-29.9, 30.0-34.9, and 35-39.9 kg/m2 were associated with a decreased risk of all-cause death, with hazard ratio (95% CI) of 0.59 (0.45-0.78), 0.61 (0.46-0.82), and 0.66 (0.47-0.92), respectively. Conversely, patients with a BMI ≥40 kg/m2 showed an increased risk of heart failure hospitalization, compared with BMI <24.9 kg/m2. Furthermore, patients in the highest quintile of obesity indices exhibited a significantly elevated hazard ratio for both all-cause death and heart failure hospitalization, compared with the lowest quintile.
CONCLUSIONS: An elevated BMI over a certain range was associated with a reduced risk of all-cause death in heart failure with preserved ejection fraction, displaying a U-shaped relationship, with no mortality reduction observed in cases of extreme obesity. In contrast, higher values of novel obesity indices were positively correlated with all-cause death and heart failure hospitalization without the obesity paradox.
INTRODUCTION: As the population ages and more patients experience medical emergencies during dental treatments, dentists must competently and confidently manage these situations. We developed a simulation training course for medical emergencies in the dental setting using an inexpensive vital sign simulation app for smartphones/tablets without the need for an expensive simulator. However, the duration for which this effect is maintained is unclear. This study was performed to evaluate the long-term educational effect at 3, 6, and 12 months after taking the course.
MATERIALS AND METHODS: Thirty-nine dental residents participated in this course. Scenarios included vasovagal syncope, anaphylaxis, hyperventilation syndrome, and acute coronary syndrome, each of which the participants had to diagnose and treat. The participants were evaluated using a checklist for anaphylaxis diagnosis and treatment skills immediately after and 3, 6, and 12 months after the course. The participants were also surveyed about their confidence in diagnosing and treating these conditions by questionnaire before, immediately after, and 3, 6, and 12 months after the course.
RESULTS: The checklist scores for anaphylaxis were significantly lower at 3, 6, and 12 months after the course than immediately after the course. The percentage of participants who provided a correct diagnosis and appropriate treatment for vasovagal syncope, hyperventilation syndrome, and acute coronary syndrome was lower at all reassessments than immediately after the course.
CONCLUSION: Because medical emergency management skills and confidence declined within 3 months, it would be useful to introduce a refresher course approximately 3 months after the initial course to maintain skills and confidence.
Those randomized to this condition focused on reducing their overall sitting time by two hours per day (a goal achieved in similar studies \[17,18\] that represented approximately a 25% reduction in daily sitting time). Participants were encouraged to reach this goal by standing in bouts of roughly 10 minutes per hour. The purpose of this arm was to investigate whether we could replicate improvements in sitting time achieved in other worksite studies in our cohort of older adults, which included both workers and non-workers.
Designed Physical Therapy Program Down syndrome children will receive the designed physical therapy program for 1 hour. The duration of treatment will be 3 times/week for 12 weeks.
The present invention includes a method that applies computer vision to detect annotation, coloring, and markup performed on paper forms that may include diagrams, typed language, fields, codes such as QR codes, orientation markers, images, workflow initiators (such as checkboxes), form information such as a version number, and language indicators, all of which are also detected. The invention automatically detects, categorizes, aligns, and converts the detections to digital annotation, coloring, markup, and coordinates. The detected annotation, coloring (including intensity, shades, and patterns), and markup includes labels, pins, areas, regions, characters, symbols, shapes, drawings, text, handwriting, codes such as QR codes. The detections are all digitized and refined in alignment with coordinate normalization. Workflow initiators like checkboxes, when checked, may trigger a digital event like a refill on a medication. An electronic record may be started or appended with digital information detected, aligned, and placed from the paper form, and the electronic record can then be modified or augmented with additional details. The application of digital information extracted from the paper form can be as simple as overlaying the detections on a digital copy of the form, or as complicated as applying neural networks for dropping pins, distribution segments, and health data onto multidimensional anatomic maps to automatically document anatomic locations, anatomic distributions, medical procedures, and diagnoses with automatic application of the documentation to calculate the correct code sets based on country and language. The digital documentation can then be modified or augmented with additional details, photos, and attachments linked directly to the anatomic site, diagnostic, or other record elements. In one such iteration, adding photographs to biopsy sites that are already mapped, labeled with correct anatomic site descriptions, and ordered with a diagnosis in place from markup on a paper map. This process being called "Augmented Documentation."
An aneurysm is most commonly defined as a permanent focal dilatation of an artery to 1.5 times its normal diameter. While the abdominal aorta is the most common site of aneurysm formation, the popliteal artery (PA) represents the second most common site of aneurysm formation, accounting for more than 70 percent of all peripheral aneurysms. A popliteal artery aneurysm (PAA) is a focal dilatation of the popliteal artery (red arrow). PAAs are rare in the general population but more commonly found in patient populations with other aneurysms, such as abdominal aortic aneurysm (AAA). Within the general population, PAAs are predominantly found in men and are extremely rare in women. There are few studies on the prevalence of PAAs in healthy individuals, but 14-19% of male and 12% of female AAA patients have PAAs. There is no clear correlation between the diameter of the AAA and the prevalence of PAA. There is furthermore a lack of consensus of the precise arterial diameter that defines a PAA.

It is paramount to identify and treat PAA patients before acute symptoms develop, given the high risk of major complications associated with acute presentation, such as major amputation. Unfortunately, there is a lack of knowledge of the natural history for PAAs, which is why surgical procedures are recommended mainly based on clinical experience and guidelines developed from insufficient scientific information. The preventive purpose, more specifically to prevent the risk of acute symptom development, should be evaluated against the frequency of complications inflicted by surgical treatment, so called "surgical risk". For this reason, it is important to evaluate the patients' health-related quality of life (HRQoL) before and after treatment in order to determine how the surgical treatment affect patients. In general, the Health-Related Quality of Life (HRQoL) is therefore emerging as an important outcome measure for interventions designed to improve patient's health, well-being, or both. There is very limited prior knowledge of HRQoL outcomes following surgical treatment of PAAs and the PAA patient's HRQoL, and whether-and to what extent- it becomes affected by the surgical treatment, is yet unknown. The surgical treatment in PAA patients and patients with peripheral arterial disease (PAD), are comparable whereas the underlying pathologies are distinct. Thus, peripheral arterial disease patients commonly experience substantial symptom relief following a surgical intervention (i.e. lower limb pain is alleviated, or ischemic wound healing is promoted). By contrast, PAA patients are often asymptomatic prior to surgery. It is therefore conceivable that a surgical intervention in PAA patients translates to a lower HRQoL after surgery than what is observed following bypass surgery for PAD. However, this needs to be further explored and confirmed in prospective studies.

Aim To investigate whether the QoL of PAA patients compared to PAD patients after surgical and potential changes over time.

Hypothesis Compared to PAD patients, femoropopliteal/femorodistal bypass surgery interventions undertaken on PAA patients result in a more pronounced negative HRQoL impact.
A method for health assessment and nutritional fortification during pregnancy enables a mother to interactively work with a caregiver to manage pregnancy from preconception through the period of breastfeeding, so as to enhance the mother's maternal health and achieve an appropriate birth weight for the baby. The method provides a battery of health tests designed to identify needs and special conditions of the mother. The health test includes genomics analysis. A customized nutritional plan and supplemental program supply both the mother and the baby with the necessary vitamins and nutrients during and after birth. The mother records information pertinent to food intake and general pregnancy. The recorded information is used by the caregiver for analysis, and also to educate the mother and network of mothers. The mother and caregiver interact to formulate an individual pregnancy plan during the duration of the pregnancy based on the health assessments and supplements.
Eligible patients will be randomised in the pre-hospital setting or on admission to the Emergency Department. POLAR study trained paramedics and physicians will screen patients in the pre-hospital setting. Eligible patients will be randomised if they fulfil the inclusion criteria with no pre-hospital exclusion criteria. Those randomised to the normothermia group will follow standard care. For those randomised to the "cooling arm", pre-hospital prophylactic hypothermia will be induced by exposure and by infusing up to 2 litres intravenous cold (4°C) 0.9% sodium chloride aiming for a core temperature of 35°C during transport. In the emergency department the "cooling arm" patients will be assessed to exclude significant bleeding and, once significant bleeding has been excluded, surface cooling vests/wraps will be applied to reach the target core temperature of 33°C. The patient will be then maintained at this temperature for a further 72 hours. Patients with significant bleeding will have cooling withheld until it is safe to decrease the temperature to the target core temperature of 33°C. Patients who have not been randomised pre-hospital will be re-screened in the ED. Eligible patients will be randomised if they fulfil the inclusion criteria with no ED exclusion criteria. Hypothermia will be induced by administration of up to 2L intravenous ice-cold (4°C) 0.9% sodium chloride followed by application of the surface cooling vests/wraps to achieve the target core temperature of 33°C. Patients allocated to standard 'normothermic' care will be maintained at a core temperature of 37°C ± 0.5°C.
<P>PROBLEM TO BE SOLVED: To obtain a composition suitable as an easily usable foamy sterilizing, disinfecting and cleaning agent having sufficiently high frothing property.  <P>SOLUTION: This composition for the foamy sterilizing, disinfecting and cleaning agent contains a nonionic surfactant selected from polyalkylene glycol ethers and polyglycerol fatty acid esters, a sterilizing component and water as essential components. Preferably, the nonionic surfactant has an HLB of ≥10 and is selected from polyglycerol fatty acid esters, and the sterilizing component is selected from hinokitiol, a hinokitiol salt and a hinokitiol complex. The composition is free from lower alcohols, anionic surfactants, amphoteric surfactants and cationic surfactants. The composition is especially suitable as a pump-foam type agent.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patient will decide which group is best for him/her. The patient will be followed at the same points as Group 1.
1414076 Preparaing viral vaccines MERCK & CO INC 1 March 1973 [6 March 1972 14 June 1972] 9978/73 Heading A5B [Also in Division C6] In processes for the controlled manufacture of a virus for human and animal vaccines by replicating virus on sheets of tissue cells in a liquid nutrient medium and harvesting the virus produced, real-time assays are performed to monitor glucose utilisation until the glucose concentration in the medium has decreased to a level in the range 20-60 mg/100 cc, the cell sheet is infected with the desired virus when the foregoing glucose concentration is reached, and then real-time assays are performed to monitor the level of isocitric dehydrogenase in the medium and the virus is harvested when the level of isocitric dehyrogenase has reached the maximum rate of change, whereby the virus is harvested at its maximum titre. According to a modification in processes for the controlled manufacture of tissue cells real-time assays are performed to monitor glucose utilization until the glucose concentration in the medium has decreased to a level in the range 5-15 mg/100 cc and the cells are then harvested, whereby the cell harvest is maximised. Examples 1 to 4 are directed to the propugation of mumps, measles or rubella virus in chick or duck embryo cells. In certain of these the use of glutamic-oxalacetic transaminase assays is disclosed in connection with achieving maximum titre of virus (c.f. the isocitric dehydrogenase assays given above). Examples 5 to 7 are directed to the culturing of WI-33, chick embryo and duck embryo cells, respectively.
The original STOP-PD study established that the combination of olanzapine and sertraline was significantly better than olanzapine alone in achieving remission of psychotic depression. This STOP-PD-II Sustaining Remission study aims to assess the long-term tolerability of taking this combination of medications and their efficacy at preventing a relapse of the symptoms. The acute phase of the study will monitor the efficacy and tolerability of the olanzapine and sertraline combination, including investigation of weight and metabolic variables, age effects on treatment response and tolerability, and the association of genetic polymorphisms to response or relapse. When subjects are stabilized on these medications for a period of 8 weeks they will be invited to participate in the randomized phase of the research: the olanzapine will be placebo-controlled, meaning half of the subjects will continue to take the olanzapine/sertraline combination and half will take a sertraline/placebo combination, for a period of 36 weeks. Symptoms and side effects will be monitored regularly throughout this phase. Randomization will be stratified on a 1:1 basis by age 60 and above.
Informed consent is an essential element of clinical research. Obtaining consent, however, may be challenging. The use of the telephone for giving information and obtaining consent may be practical but little formal research has been done.

This study examined the use of the telephone for the purpose of informing expectant mothers about a randomized clinical trial assessing neonatal Bacille Calmette-Guérin vaccination. Expectant mothers who were contacted for participation in the Calmette Study were randomised to receive information by telephone or at a face-to-face consultation. The primary outcome was a communication score, consisting of comprehension of information about the study and satisfaction with the information process. The outcome was measured using a questionnaire two days after the information was provided and two and a half months after birth.
Elevated Liver Enzymes

Chateal EQ is contraindicated in females with acute viral hepatitis or severe (decompensated) cirrhosis of liver (see CONTRAINDICATIONS). Discontinue Chateal EQ if jaundice develops. Acute liver test abnormalities may necessitate the discontinuation of COC use until the liver tests return to normal and COC causation has been excluded.

Liver Tumors

Chateal EQ is contraindicated in females with benign or malignant liver tumors (see CONTRAINDICATIONS). COCs increase the risk of hepatic adenomas. An estimate of the attributable risk is 3.3 cases/100,000 COC users. Rupture of hepatic adenomas may cause death from abdominal hemorrhage.

Studies have shown an increased risk of developing hepatocellular carcinoma in long-term (> 8 years) COC users. The attributable risk of liver cancers in COC users is less than one case per million users.
The invention discloses a multimode magnetic resonance imaging probe for fluorine-19, phosphorus-31 and chemical exchange saturation transfer and application thereof. Belongs to the technical field of medical imaging. The probe belongs to lipid nano-particles, is prepared from lipid and buffer water solution, and can realize multi-mode magnetic resonance imaging of heteronuclear ( 19 F, 31  P) spectrum and CEST MRI. The lipid nanoparticle probe can form a stable wrapping structure and has good biocompatibility. The lipid part comprises carboxylic acid betaine type fluorinated lipid and phospholipid, and  19 F, 31  P heteronuclear and CEST multimode detection can be realized on the same magnetic resonance scanning platform. The buffered aqueous solution contains one or more hydrophilic fluorochemicals that provide  19  F MRI-specific imaging of single or multiple magnetic resonance frequencies on  19  F MRI images. This multi-modality MRI detection provides complementarity of various image information, providing a new solution for lipid nanoparticle in vivo detection.
Stearoyl-CoA desaturase-1 (SCD1) is a pivotal enzyme in lipogenesis, which catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated fatty acids, whose ablation downregulates lipid synthesis, preventing steatosis and obesity. Yet deletion of SCD1 promotes hepatic inflammation and endoplasmic reticulum stress, raising the question of whether hepatic SCD1 deficiency promotes further liver damage, including fibrosis. To delineate whether SCD1 deficiency predisposes the liver to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC), we employed in vivo SCD1 deficient global and liver-specific mouse models fed a high carbohydrate low-fat diet and in vitro established AML12 mouse cells. The absence of liver SCD1 remarkably increased the saturation of liver lipid species, as indicated by lipidomic analysis, and led to hepatic fibrosis. Consistently, SCD1 deficiency promoted hepatic gene expression related to fibrosis, cirrhosis, and HCC. Deletion of SCD1 increased the circulating levels of Osteopontin, known to be increased in fibrosis, and alpha-fetoprotein, often used as an early marker and a prognostic marker for patients with HCC. De novo lipogenesis or dietary supplementation of oleate, an SCD1-generated MUFA, restored the gene expression related to fibrosis, cirrhosis, and HCC. Although SCD1 deficient mice are protected against obesity and fatty liver, our results show that MUFA deprivation results in liver injury, including fibrosis, thus providing novel insights between MUFA insufficiency and pathways leading to fibrosis, cirrhosis, and HCC under lean non-steatotic conditions.
During clinical routine, intraoperative handover of anaesthesia care occurs frequently. This handover between two anaesthesiologists requires the transmission of all relevant information concerning the patient and the ongoing procedure. Studies regarding the influence of such handovers on patient outcome are inconclusive and mostly of retrospective nature. Some studies report a negative effect of handovers on patients mortality and outcome, however studies exist reporting no effect. A positive effect of intraoperative handovers as a result of a "second man" effect ist also possible. To increase handover quality, the German Society of Anaesthesiology and Intensive Care Medicine (DGAI) recommends the application of the situation, background, assessment and recommendation (SBAR) concept. Information are arranged in those four groups with the goal of structuring the handover and incorporating all relevant information. Studies show increased accuracy of transferred information and improved comprehensibility when using the SBAR concept. Whether an intraoperative handover according to the SBAR concept reduces the rate of postoperative complications is not yet investigated. Due to lack of information regarding feasibility and effect size, the investigators plan a prospective pilot study to answer these questions. Initially, patients undergoing major surgery are recruited where handover is performed without a standardized handover. After the implementation of a checklist using the SBAR concept, this checklist will be used during intraoperative handover in recruited patients where a handover occurs. The primary endpoint is a combined endpoint consisting of all-cause mortality, readmission to any hospital, or major postoperative complications. Additionally, implementation rate and efficacy of the checklist will be evaluated.
A cosmetic composition comprising block polymer and non-volatile silicone oil is provided, which composition has improved depositing activity on the keratin materials such as skin or lip, and does not easily wiped from the keratin materials. The cosmetic composition comprises the block polymer and a cosmetically acceptable organic liquid medium containing non-volatile fatty phase liquid, wherein the block polymer is film forming linear ethylene polymer; the non-volatile fatty phase liquid comprises 30 wt.% or more of non-volatile silicone oil; the block polymer is free from styrene; the block polymer is not elastomer; the block polymer comprises at least one first block and at least one second block having different vitreous transition temperature(Tg), and the first and second blocks are connected between them by an intermediate block including at least one constitutive monomer of the first block and at least one constitutive monomer of the second block; and the first block has a Tg temperature selected from 40 deg. C or more, 20 deg. C or less, and between 20 deg. C to 40 deg. C.