anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving glyburide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glyburide, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving glyburide, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving glyburide, the patient should be observed closely for hypoglycemia.

A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide. The mechanism for this interaction is not known.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical or vaginal preparations of miconazole is not known.

### Metformin

In a single-dose interaction study in NIDDM subjects, decreases in glyburide AUC and Cmax were observed, but were highly variable. The single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effects, makes the clinical significance of this interaction uncertain. Coadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics.
Near infrared spectroscopy (NIRS) is a noninvasive tool used for continuous monitoring of regional tissue oxyhemoglobin saturation. Sensors are placed on the head and abdomen or flank and use light to measure the percent oxygen levels in tissues. Head NIRS has been correlated with oxygen levels of the blood returning from the brain, and an abrupt decline in post-operative cardiac patients has been shown in retrospective studies to predict an impending event such as cardiac arrest. Animal studies have demonstrated that somatic NIRS monitoring is able to detect flow-induced changes in regional oxygen levels of the kidney and gut directly under the sensor. Unlike cerebral NIRS monitoring, there is no data regarding the clinical utility of NIRS over the abdomen and flank in predicting outcomes. Children are at risk of decreased organ perfusion following cardiac surgery, and is a phenomenon termed low cardiac output syndrome (LCOS). It occurs in approximately 25% of neonates and young children following cardiac surgery. The effects of LCOS on end organ function, specifically the kidney may result in acute kidney injury, thereby increasing morbidity and mortality. The incidence of acute kidney injury (AKI) following cardiac surgery is reported as high as 40%. The use of NIRS in the operating room to detect AKI in pediatric patients undergoing cardiac surgery is the focus of this proposal Specific Aim 1: Determine if a reduction in renal NIRS intra-operatively identifies patients with AKI Hypothesis: Reduced intra-operative renal NIRS will precede the diagnosis of acute kidney injury by an increase in serum creatinine within 1 to 3 days post-cardiopulmonary bypass Specific Aim 2: Determine if a reduction in renal NIRS intra-operatively correlates with increases in emerging biomarkers of AKI.

Hypothesis: Reduced intra-operative renal NIRS will precede the development if AKI as detected by neutrophil gelatinase-associated lipocalin, IL-6 and IL-18 by at least 2 hours.
IV placement is necessary for lidocaine infusions. Unfortunately, some patients say that placing an IV is painful. The investigators are conducting this study to evaluate two techniques that could make the placement of the IV more comfortable. Currently, some medical providers administer the IV without any pain-relieving techniques. Some medical providers place a device called Buzzy® on a patient's arm prior to the IV placement. The Buzzy® device is the combination of an ice pack and a vibrator in the shape of a bumble bee. Literature shows that the Buzzy® device makes IV placement more comfortable for children, but there is minimal data in regard to whether it is helpful for adult patients. The investigators are conducting this study to compare the effectiveness of the Buzzy® device with that of no pain relief method for IV placement in adults with chronic pain receiving lidocaine infusions. The use of the Buzzy® device in adults is the investigational part of the study. This device has been FDA approved for use.
A randomized controlled trial design will be employed to investigate the effectiveness, feasibility, and acceptability of a technology-based weight loss pilot intervention for the reduction of overweight and obesity in college students. Participants will be randomly assigned to one of two conditions: (1) 8-week intervention group, or (2) 8-week attention control group. Both conditions include 8 weekly lessons over 8 weeks. Undergraduate students (n=100) age 18-22 years who are overweight or obese (BMI ≥ 25 kg/m2) will be recruited from the University of Tennessee Knoxville. Measurements will be taken at baseline and 8 weeks. Since the study is a technology-based intervention, research staff will collect height and weight measures for BMI through a novel approach, utilizing Skype video conferencing.
PURPOSE:To provide a gypsum mold material obtained by compounding colloidal silica to a mixture of beta-type gypsum hemihydrate, resistant to the compression molding at a temperature to soften and melt a thermoplastic resin, and capable of giving a plastic denture base having the accurate shape of the original model. CONSTITUTION:The objective material is obtained by mixing (A) 100pts.wt. of a mixture composed of (i) 10-90(wt)%, preferably 20-80% beta-type hypsum hemihydrate and (ii) 90-10%, preferably 80-20% silicon dioxide (preferably crystabalite in view of the thermal expansion) with (B) 10-200pts.wt., preferably 10-100pts.wt. of colloidal silica. The expansion of the mold at the softening temperature of the used thermoplastic resin can be adjusted to the desired level by properly selecting the ratio of gypsum to silicon dioxide. The strength of the mixture can be improved remarkably the addition of colloidal silica, and a denture base resistant to the compression molding of the thermoplastic resin and replicating the accurate shape of the original model can be produced by this process.
The invention discloses a lozenge treating chronic pharyngitis. The lozenge is prepared from 10-15 parts of radix ophiopogonis, 10-15 parts of momordica grosvenori, 10-15 parts of hen egg membranes, 6-8 parts of fritillary bulbs, 6-8 parts of liquorice, 8-10 parts of scrophulariae, 8-10 parts of platycodon grandiflorum, 8-10 parts of oroxylum indicum, 15-18 parts of dried radix rehmanniae and auxiliary materials. The auxiliary materials are one or more of dextrin, mannitol, powdered sugar and menthol. The auxiliary materials include 30-50 parts of dextrin, 10-20 parts of mannitol, 10-20 parts of powdered sugar and 2-3 parts of menthol. The traditional Chinese medicine treating chronic pharyngitis is summarized through many years of practices of medical staff and forms lozenges capable of being taken by people conveniently through processing, and the lozenge can be completely dissolved and released within 15 min in the oral cavity. Besides, the lozenge is convenient to take and carry, and a good drug is provided for clinical prevention, chronic pharyngitis treatment and oral cavity sterilization and is very worthy of application and popularization.
Nanjing Medical University analyzed a systematic review article 7 of 14 randomized trials of traditional Chinese medicine in improving WBC count, Card-type physical function and quality of life scale (Karnofsky Performance Scale, KPS), infectious dose, and G-CSF use. According to statistics on the rate and incidence of leukopenia, it was found that CHM chemotherapy was adjusted to use western medicine plus chemotherapy. However, clinical considerations suggest that some patients with low leukocytes have poor cosmetics and are unable to meet the three-times-a-day dosage. A review of the literature found that traditional Chinese medicine powder is applied to acupoints to treat various diseases, such as primary menstrual pain 8 and chronic obstructive pulmonary disease 9 , Vomiting after general anesthesia for orthopedic surgery 10 may be treated. There are 4 articles on the Chinese Journal online using traditional Chinese medicine to treat adverse reactions after chemotherapy, including grinding traditional Chinese medicine into paste and applying it to acupoints to improve mixed leukopenia11; analysis of the correlation between traditional Chinese medicine acupoint application in the treatment of malignant tumors from 2010 to 2020 Literature, statistics on commonly used Chinese medicines, acupoints and preparation methods, found that acupoint application can improve leukopenia, constipation, vomiting and other adverse reactions in cancer patients after chemotherapy12; Chinese medicine powder mixed with petroleum jelly and applied to acupoints combined with Chinese medicine liquid injection can improve platinum Chemotherapy drugs cause vomiting, ointment, constipation, low liver function and low blood cells13; using Guilu Erxian glue patch directly improves low white blood cells and neutrophils after chemotherapy for intestinal cancer14. Therefore, local topical traditional Chinese medicine application therapy is not used for research design.
Phytophthora infestans is a notorious oomycete pathogen that causes potato late blight. It secretes numerous effector proteins to manipulate host immunity. Understanding mechanisms underlying their host cell manipulation is crucial for developing disease resistance strategies. Here, we report that the conserved RXLR effector Pi05910 of P. infestans is a genotype-specific avirulence elicitor on potato variety Longshu 12 and contributes virulence by suppressing and destabilizing host glycolate oxidase StGOX4. By performing co-immunoprecipitation, yeast-two-hybrid assays, luciferase complementation imaging, bimolecular fluorescence complementation and isothermal titration calorimetry assays, we identified and confirmed potato StGOX4 as a target of Pi05910. Further analysis revealed that StGOX4 and its homologue NbGOX4 are positive immune regulators against P. infestans, as indicated by infection assays on potato and Nicotiana benthamiana overexpressing StGOX4 and TRV-NbGOX4 plants. StGOX4-mediated disease resistance involves enhanced reactive oxygen species accumulation and activated the salicylic acid signalling pathway. Pi05910 binding inhibited enzymatic activity and destabilized StGOX4. Furthermore, mutagenesis analyses indicated that the 25th residue (tyrosine, Y25) of StGOX4 mediates Pi05910 binding and is required for its immune function. Our results revealed that the core RXLR effector of P. infestans Pi05910 suppresses plant immunity by targeting StGOX4, which results in decreased enzymatic activity and protein accumulation, leading to enhanced plant susceptibility.
Individuals known to carry or at risk for carrying non-EGFR germline mutations (e.g., HER2, BRCA2, MET, YAP1, and others that will be identified). Patients with lung cancer with a somatic variant suggestive of a possible hereditary lung cancer risk are also eligible.
Teratogenic Effects

Pregnancy Category B. There are no adequate and well-controlled studies with dexlansoprazole in pregnant women. There were no adverse fetal effects in animal reproduction studies of dexlansoprazole in rabbits. Because animal reproduction studies are not always predictive of human response, DEXILANT should be used during pregnancy only if clearly needed.

A reproduction study conducted in rabbits at oral dexlansoprazole doses up to approximately 9 times the maximum recommended human dexlansoprazole dose (60 mg per day) revealed no evidence of impaired fertility or harm to the fetus due to dexlansoprazole. In addition, reproduction studies performed in pregnant rats with oral lansoprazole at doses up to 40 times the recommended human lansoprazole dose and in pregnant rabbits at oral lansoprazole doses up to 16 times the recommended human lansoprazole dose revealed no evidence of impaired fertility or harm to the fetus due to lansoprazole [see Nonclinical Toxicology (13.2)].
Diseases of joints are among the most frequent causes of chronic pain. In the course of joint diseases, the peripheral and the central nociceptive system develop persistent hyperexcitability (peripheral and central sensitization). This review addresses the mechanisms of spinal sensitization evoked by arthritis. Electrophysiological recordings in anesthetized rats from spinal cord neurons with knee input in a model of acute arthritis showed that acute spinal sensitization is dependent on spinal glutamate receptors (AMPA, NMDA, and metabotropic glutamate receptors) and supported by spinal actions of neuropeptides such as neurokinins and CGRP, by prostaglandins, and by proinflammatory cytokines. In several chronic arthritis models (including immune-mediated arthritis and osteoarthritis) spinal glia activation was observed to be coincident with behavioral mechanical hyperalgesia which was attenuated or prevented by intrathecal application of minocycline, fluorocitrate, and pentoxyfylline. Some studies identified specific pathways of micro- and astroglia activation such as the purinoceptor- (P2X7-) cathepsin S/CX3CR1 pathway, the mobility group box-1 protein (HMGB1), and toll-like receptor 4 (TLR4) activation, spinal NFκB/p65 activation and others. The spinal cytokines TNF, interleukin-6, interleukin-1β, and others form a functional spinal network characterized by an interaction between neurons and glia cells which is required for spinal sensitization. Neutralization of spinal cytokines by intrathecal interventions attenuates mechanical hyperalgesia. This effect may in part result from local suppression of spinal sensitization and in part from efferent effects which attenuate the inflammatory process in the joint. In summary, arthritis evokes significant spinal hyperexcitability which is likely to contribute to the phenotype of arthritis pain in patients.
The present invention discloses a medicating moxibustion musk bolus which is formed by preparing main musk, homalomena rhizoma, cinnamon, radix aconiti, wild aconite, liquorice, kapur and tide brains according to certain weight proportions to form the bolus with the diameter of 2 to 3cm. The present invention comprises all kinds of medicine and can treat various diseases. Medicinal powder directly permeates into acupoints, skin, channels and pathologic change areas. The present invention has the advantages of strong medicinal effect, obvious curative effect, long moxibustion exerting time, flexible moxibustion exerting mode, large moxibustion exerting range and easy invigoration. The medicating moxibustion musk bolus of the present invention has the advantages of pleasant aroma, no smoking, no foreign odour and no cicatrice. The present invention is widely used for treating common diseases such as inner diseases, woman diseases, child diseases, skin diseases, five sense organ diseases, etc., by moxibustion, and can also be used for rescuing emergency patients and treating special puzzled disease symptoms by the moxibustion.
PURPOSE: This study retrospectively assessed blood loss during cesarean deliveries for twin and singleton pregnancies using two distinct methods, quantitative estimation measured during cesarean sections and hematocrit-based calculated estimation.
METHODS: We included scheduled cesarean deliveries for twin or singleton pregnancies at ≥ 34 weeks of gestation. Quantitative blood loss was recorded based on the blood volume in the graduated collector bottle and by weighing the blood-soaked textiles during cesarean sections. The blood loss was calculated using the change in hematocrit levels before and after the cesarean delivery.
RESULTS: We evaluated 403 cases including 44 twins and 359 singletons. Quantitative blood loss during cesarean section was significantly higher in twin pregnancies than that in singleton pregnancies (1117 [440] vs 698 [378] mL; p < 0.001). However, no significant differences were observed in the calculated blood loss between the two groups on the day after delivery (487 mL [692 mL] vs 507 mL [522 mL]; p = 0.861). On post-delivery days 4-5, twin pregnancies were associated with a significantly higher calculated blood loss than singleton pregnancies (725 [868] mL vs 444 [565] mL, p = 0.041). Although a significant moderate correlation between quantitative and calculated blood loss was observed in singleton pregnancies (r = 0.473, p < 0.001), no significant correlation was observed between twin pregnancies (r = 0.053, p = 0.735).
CONCLUSION: Quantitative blood loss measurements during cesarean section may be clinically insufficient in twin pregnancies. Incorporating blood tests and continuous assessments are warranted for enhanced blood loss evaluation, especially in twin pregnancies, owing to the risk of persistent bleeding.
A surgical guide assembly having an attachment device configured to be coupled to a bone. A cut location indicator is coupled to the attachment device. The cut location indicator identifies a location where the bone is to be cut. An arm is coupled to the attachment device, tire cut location indicator, or both. A support structure is coupled to the arm. The support structure is configured to have a trackable feature coupled thereto.
An image data forming apparatus includes a storage unit storing original image data, a buffer unit temporarily storing a part of the original image data, an output unit, a priority setting unit, a control unit, and an analysis unit. The output unit forms image data from the original image data, outputs the image data, and uses, if data needed to form the image data is stored in the buffer unit, the stored needed data. The priority setting unit divides the original image data into a blocks and set priorities for blocks. The control unit performs control so that image data of those blocks having a high priority is stored in the buffer unit by priority. The analysis unit analyzes, if the original image data is accompanied by data of annotations, position information about the annotations. The priority setting unit sets the priorities based on an analysis result.
The invention discloses alkyl alcohol polyoxyethyl ether polysiloxane and its use. The alkyl alcohol polyoxyethyl ether polysiloxane has a general structural formula shown in the patent specification. A preparation method of the alkyl alcohol polyoxyethyl ether polysiloxane comprises the following step that 1, alkyl alcohol polyoxyethyl ether and an alkali compound undergo a heating reaction in methylbenzene to produce an alkali metal salt of alkyl alcohol polyoxyethyl ether; and the alkali metal salt and chloropropene undergo a reaction to produce allyl-terminated alkyl alcohol polyoxyethyl ether; and 2, in the presence of a platinum catalyst, the allyl-terminated alkyl alcohol polyoxyethyl ether and low-hydrogen content silicone oil undergo a reaction to produce the alkyl alcohol polyoxyethyl ether polysiloxane oil. The alkyl alcohol polyoxyethyl ether polysiloxane as an emulsifier can be added into W/O cream, and can effectively emulsify an oil phase containing silicone oil or a silicone oil-other oil compound. The cream with the alkyl alcohol polyoxyethyl ether polysiloxane has excellent stability under the conditions of a high temperature, freezing/unfreezing circulation, long-term storage and solarization. A W/O cream emulsion with the alkyl alcohol polyoxyethyl ether polysiloxane has high viscosity, high stability and good compatibility with the skin.
Functional abdominal pain is a disorder in which central and peripheral sensitization processes converge, leading to hypersensitivity and allodynia. Differential diagnosis is made with organic digestive, renal, gynecological, endocrine, or neurological diseases. Treatment should be individualized for each patient. In cases of debilitating pain, therapy combining drugs with different mechanisms of action can be initiated, while in less severe cases, therapy with a progressive introduction of drugs based on clinical response is advised. The first line includes general lifestyle advice and antispasmodic substances, like peppermint oil, anticholinergic/antimuscarinic, and calcium channels antagonists. In the second line of treatment, neuromodulating agents are added. Finally, when these measures fail, third-line treatments such as gabapentine and atypical antipsychotics are considered. Psychological interventions should be considered if specialized therapists are available to manage these disorders.
PROBLEM TO BE SOLVED: To obtain a manicure preparation which is easily applied to nails, possesses excellent drying property and gloss, gives slight oppressive feeling to nails and is difficult to be exfoliated even on over time by including a nitrocellulose, a solvent and a specific nonaqueous polymer dispersion. SOLUTION: This manicure preparation is obtained by including a nonaqueous polymer dispersion which is obtained by dispersing a polymer (e.g. a polymer or the like of acrylic ester or methacrylic ester) into a mixture of (A) a nitrocellulose (e.g. nitrocellulose HIG 1/4 second or the like), (B) a solvent (e.g. butyl acetate, ethyl acetate, isopropyl alcohol or the like) and (C) a volatile silicone, preferably a compound of formula I [(n) is 3-7] or formula II [(m) is 0-5] and preferably contains a sugar benzoate. On the above cosmetic, the components A, B and C are preferably included in proportions of 5-25 wt.%, 25-85 wt.% and 10-60 wt.%, respectively.
Delefilcon A multifocal contact lenses in Period 1, followed by subject's habitual multifocal contact lenses in Period 2. Each product worn bilaterally (in both eyes) for 14 ± 3 days.