anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most prevalent hereditary kidney disease, affecting 12.5 million people worldwide in all ethnic groups. ADPKD is caused by a gene mutation in either PKD1 or PKD2, that leads to the formation and growing of multiple fluid-filled cysts in the kidneys and often the liver, leading to chronic kidney injury and ultimately end-stage renal disease. In ADPKD, kidney function may remain normal for several decades and is therefore not fully informative. The identification of early biomarkers able to accurately monitor and predict disease progression in order to take prompt action and select targeting treatment options is urgently needed. Total kidney volume has been recognized as a prognostic biomarker to select patients for clinical trials and is acknowledged by the scientific community as a relevant biomarker to monitor disease progression and response to therapy, and to predict ADPKD course. Total kidney volume can be quantified using medical images, such as Ultrasound, Computed Tomography, and Magnetic Resonance Imaging (MRI). Renal non-contrast enhanced MRI, denoted by high resolution and with no need for contrast agents or ionizing radiation, is the most suited to monitor total kidney volume progression over time and clearly detect kidney cysts. Since many ADPKD patients also have polycystic livers, total liver and liver cyst volume may provide additional relevant information.

Total kidney, liver, and cyst volume measurements are based on kidney segmentation, which is generally performed by manual contouring, an operator-dependent and time-consuming task requiring dedicated expertise. Automatic or semi-automatic methods for kidney and cysts segmentation have been proposed in the past based on traditional approaches and artificial intelligence (AI) techniques. However, the low explainability and the need of large and curated datasets allowing to obtain accurate and generalized models have so far hampered their wide adoption in clinical research. A fully automatic segmentation method for the accurate identification of kidneys, liver, and cysts would be highly desirable.

Beyond kidney, liver, and cyst volume quantification, the characterization of non-cystic renal tissue may provide additional relevant information on ADPKD pathophysiology. Few years ago, a contrastenhanced CT study revealed the presence of peritubular interstitial fibrosis in the non-cystic component of ADPKD kidneys, that was associated with renal function and its decline over time, confirmed more recently by an independent study on dynamic contrast-enhanced T1-weighted MRI. Advanced image processing techniques, such as radiomics, which aims to compute high throughput information from radiological images for the characterization of tissue spatial heterogeneity, show potential to characterise tissue microstructure. Preliminary attempts on ADPKD patients were performed on T1-weighted and T2-weighted MRI scans. Besides, radiomics could be helpful to build multiparametric stratification and prediction models including image-based features.
Under local or general anesthesia, autologous fat will be harvested by using a manual aspiration or syringe-assisted technique. SVF and ASCs isolation from autologous lipoaspirates will be done by enzymatic digestion method (collagenase Type-1 solution for 45 minutes at 37°C). Cell quality assessment will be done prior to transplantation by trypan blue exclusion assay and total populations and fractions of cells identified by immunocytochemistry / flow cytometry. PRP will be derived by centrifugation from 50-100ml blood collected in anticoagulant carrying bag, from patient at the day of transplantation. The injection volume will depend on the wound area of each patient. 2 million cells/ 0.5 ml PRP will be mixed, transferred to 1 cc syringes and injected / cm2 intradermally at the border zone \& inside of wound surface bed.
Stimulation frequency is set similar to that of the tremor and the amplitude is set up to 5 mA peak amplitude (with the help of local anesthetic cream and amplitude is reduced if not uncomfortable). A set of 4\*1 gel-filled cup-electrodes is placed over each of motor cortex and the occipital cortex respectively. Each subject follows three sessions of 12 min length each. During each session the tremor is measured while interleaving between Motor cortex stimulation, Occipital cortex stimulation and No stimulation. By the end of each session we get 3 min of Motor Cortex stimulation, 3 min of occipital Cortex stimulation and 6 min of No stimulation.
Administered once daily over 30 days, using a sham coil that reproduces auditory and tactile sensations of stimulation and has an identical external appearance. Each session will deliver 600 pulses of sham iTBS in triplet 50Hz bursts, repeated at 5Hz 2s on 8s off for a total time of \~3 minutes, 9 seconds at a target intensity of 120% of the subject's resting motor threshold.
Up to 4 dose levels of subcutaneous AKB-9778 will be evaluated. Doses will be administered daily for 28 days.
The invention relates to a dietotherapy medicament for treating gastric ulcer and duodenal ulcer and a preparation method thereof. The dietotherapy medicament is prepared by the following materials by weight: 3-12 portions of sepium and 30-80 portions of honey. The preparation method of the medicament comprises the steps as follows: (1) the honey is steamed for standby; (2) the sepium is washed and disinfected; (3) the crust of the disinfected sepium is removed and the sepium is crushed; (4) the crushed sepium powder is filled into capsules for standby; and (5) the steamed honey is drunk in limosis situation, and then the sepium capsule is taken. The dietotherapy medicament is health-care medicine, has important breakthrough in treating the gastric ulcer and the duodenal ulcer and efficacy of resisting ulcer and tumor, restricting acid, relieving pain, astringing and stopping bleeding, astringing dampness and sore, clearing away heat and toxic material, promoting the circulation of qi and diminishing inflammation as well as the efficacy of astringency, hemostasis and hygroscopic nature without any toxic side effect, and is used safely and effectively. The dietotherapy medicament is used for treating more than 90 medical cases of gastric ulcer and duodenal ulcer. The curative effect is determined after the dietotherapy medicament is used for four weeks, and the effective rates are respectively 98 percent and 96.6 percent for gastric ulcer and duodenal ulcer. Followed visit to patients after half year shows that gastric ulcer and duodenal ulcer are not recur to the patients.
Pregnancy Category C. Dexamethasone has been shown to be teratogenic in mice and rabbits following topical ophthalmic application in multiples of the therapeutic dose.

In the mouse, corticosteroids produce fetal resorptions and a specific abnormality, cleft palate. In the rabbit, corticosteroids have produced fetal resorptions and multiple abnormalities involving the head, ears, limbs, palate, etc.

There are no adequate or well-controlled studies in pregnant women. Neomycin and polymyxin B sulfates and dexamethasone ophthalmic suspension should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be observed carefully for signs of hypoadrenalism.
Exploration of the intricate connections between long noncoding RNA (lncRNA) and diseases, referred to as lncRNA-disease associations (LDAs), plays a pivotal and indispensable role in unraveling the underlying molecular mechanisms of diseases and devising practical treatment approaches. It is imperative to employ computational methods for predicting lncRNA-disease associations to circumvent the need for superfluous experimental endeavors. Graph-based learning models have gained substantial popularity in predicting these associations, primarily because of their capacity to leverage node attributes and relationships within the network. Nevertheless, there remains much room for enhancing the performance of these techniques by incorporating and harmonizing the node attributes more effectively. In this context, we introduce a novel model, i.e., Adaptive Message Passing and Feature Fusion (AMPFLDAP), for forecasting lncRNA-disease associations within a heterogeneous network. Firstly, we constructed a heterogeneous network involving lncRNA, microRNA (miRNA), and diseases based on established associations and employing Gaussian interaction profile kernel similarity as a measure. Then, an adaptive topological message passing mechanism is suggested to address the information aggregation for heterogeneous networks. The topological features of nodes in the heterogeneous network were extracted based on the adaptive topological message passing mechanism. Moreover, an attention mechanism is applied to integrate both topological and semantic information to achieve the multimodal features of biomolecules, which are further used to predict potential LDAs. The experimental results demonstrated that the performance of the proposed AMPFLDAP is superior to seven state-of-the-art methods. Furthermore, to validate its efficacy in practical scenarios, we conducted detailed case studies involving three distinct diseases, which conclusively demonstrated AMPFLDAP's effectiveness in the prediction of LDAs.
The invention discloses a salmonella typhimurium X3337 and applications of the salmonella typhimurium X3337 in living body imaging. The bacterial strain is preserved in depositary authority designated by the state intellectual property office, the preservation data is 13 March, 2012, the depositary authority is China general microbiological culture collection center, and the preservation number is CGMCC No.5894. The salmonella typhimurium X3337 is the bacterial strain after the elimination of virulent plasmids, and can be taken as a reference to be used for researching the functions of the virulent plasmid of salmonella typhimurium. X3337lux is salmonella typhimurium bacterial strain with a stable biological luminescence property. The salmonella typhimurium X3337 complements have the defects that an excitation light source is needed by the detection of bioluminescence bacteria, the specificity of the salmonella typhimurium X3337 in a body is low, the background is high, the quantity is difficult to determine and the like. The salmonella typhimurium X3337 can be widely applied to establishing an in-vitro cell infection model and an in-vivo experiment model. A convenient tool is provided for the intensive study of the pathogenic mechanism of salmonella typhimurium, drug researching and screening and related disease preventing strategy researching and the like.
<P>PROBLEM TO BE SOLVED: To provide a composition containing a visual marker, used for observing medication compliance of a patient with a medication plan, and to provide a method for the same.  <P>SOLUTION: The marker is made to adhere to an orally administrable pharmaceutical, or ingested with the pharmaceutical, by being together prescribed with a rapidly soluble layer. The marker is released, when the pharmaceutical is ingested, so that detectable marker induction properties are brought about in the patient's oral cavity and/or pharyngeal cavity. Whether the pharmaceutical is ingested or not is determined based on existence or nonexistence of the properties, by testing the patient's oral and/or pharyngeal cavity and a site belonging to the patient. Further, the composition is used for tracking a position in which the pharmaceutical is not ingested.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Major depressive disorder (MDD) is a devastating and heterogenous disorder for which there are no approved biomarkers in clinical practice. We recently identified anticipatory hypo-arousal indexed by pupil responses as a candidate mechanism subserving depression symptomatology. Here, we conducted a replication and extension study of these findings. We analyzed a replication sample of 40 unmedicated patients with a diagnosis of depression and 30 healthy control participants, who performed a reward anticipation task while pupil responses were measured. Using a Bayesian modelling approach taking measurement uncertainty into account, we could show that the negative correlation between pupil dilation and symptom load during reward anticipation is replicable within MDD patients, albeit with a lower effect size. Furthermore, with the combined sample of 136 participants (81 unmedicated depressed and 55 healthy control participants), we further showed that reduced pupil dilation in anticipation of reward is inversely associated with anhedonia items of the Beck Depression Inventory in particular. Moreover, using simultaneous fMRI, particularly the right anterior insula as part of the salience network was negatively correlated with depressive symptom load in general and anhedonia items specifically. The present study supports the utility of pupillometry in assessing noradrenergically mediated hypo-arousal during reward anticipation in MDD, a physiological process that appears to subserve anhedonia.
OBJECTIVE: Pediatric neuro-oncological surgery is often associated with significant risk; however, comprehensive data on surgical morbidity remain limited. The purpose of this study was therefore to provide national population-based data on both the incidence and characteristics of poor postoperative outcomes following pediatric intracranial neuro-oncological surgery. Additionally, the authors aimed to evaluate key risk factors for poor postoperative outcomes including overall morbidity, significant morbidity, and the most frequent types of morbidity.
METHODS: The authors conducted a registry-based, nationwide, retrospective study including all children receiving surgical treatment for a CNS tumor over a 10-year period. Patients were identified using the Danish Childhood Cancer Registry, and 30-day morbidity was assessed through manual review of electronic health records. Significant morbidity was defined as complications in need of treatment under general anesthesia, ICU admission, or persistent neurological deficits at 30 days following surgery or death. Risk factors including sex, age, tumor location, tumor malignancy grade, and preoperative hydrocephalus were investigated using multivariate logistic regression analysis.
RESULTS: A total of 349 children undergoing 473 tumor procedures were included, with an overall morbidity rate of 66.0% and a significant morbidity rate of 34.2%. The most frequent complications included neurological deficits (41.4%) and CSF-related morbidity consisting of CSF leaks, pseudomeningoceles, and postoperative hydrocephalus. Highly significant associations between infratentorial tumor location and both significant morbidity (OR 1.26, 95% CI 1.11-1.43; p < 0.001) and neurological deficits (OR 1.38, 95% CI 1.21-1.57; p < 0.001) were identified. In addition, younger age was revealed as a major risk factor of both postoperative CSF leakage and CSF-related morbidity in general.
CONCLUSIONS: In this large, population-based cohort, the authors show that postoperative morbidity is frequent, occurring in about two-thirds of all patients, largely driven by neurological deficits and CSF-related complications. In addition, infratentorial tumor location and younger age emerged as key risk factors for poor postoperative outcomes.
The ProTaper Next (PTN) system is produced by adding M-Wire alloy to the ProTaper Universal (PU) system. With the M-Wire alloy, it is aimed to increase the flexibility and cyclic fatigue resistance of the files. The combination of three important design features in PTN files, including changing taper on a single file, M-wire technology and offset design, is one of the important features that distinguish it from other files. PTN X1 and X2 files have both an ascending and a descending conical design on a single file; PTN X3, X4 and X5 files have a constant taper from D1-D3, then taper design that tapers off over the rest of their active segments.
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. The soluble form (sFKN) has chemotactic properties and strongly attracts T cells and monocytes. The membrane-bound form (mFKN) facilitates diapedesis and is responsible for cell-to-cell adhesion, especially by promoting the strong adhesion of leukocytes (monocytes) to activated endothelial cells with the subsequent formation of an extracellular matrix and angiogenesis. FKN signaling occurs via CX3CR1, which is the only known member of the CX3C chemokine receptor subfamily. Signaling within the FKN-CX3CR1 axis plays an important role in many processes related to inflammation and the immune response, which often occur simultaneously and overlap. FKN is strongly upregulated by hypoxia and/or inflammation-induced inflammatory cytokine release, and it may act locally as a key angiogenic factor in the highly hypoxic tumor microenvironment. The importance of the FKN/CX3CR1 signaling pathway in tumorigenesis and cancer metastasis results from its influence on cell adhesion, apoptosis, and cell migration. This review presents the role of the FKN signaling pathway in the context of angiogenesis in inflammation and cancer. The mechanisms determining the pro- or anti-tumor effects are presented, which are the cause of the seemingly contradictory results that create confusion regarding the therapeutic goals.
BACKGROUND: CircRNAs have been demonstrated to play a crucial role in regulating the growth and progression of various cancers, including hepatocellular carcinoma (HCC). Nevertheless, the circRNA's expression pattern and function in HCC need more investigation.
METHODS: Bioinformatics techniques were used to identify differentially expressed circRNAs in HCC. CircASH2L expression in HCC tissues was assessed through qRT-PCR and ISH analysis. To assess circASH2L's impact on HCC progression, a variety of experiments were carried out both in vitro and in vivo, such as CCK8, colony formation, EdU assay, flow cytometry, transwell assay, and xenograft mouse model. Various experimental techniques including qRT-PCR, dual luciferase reporter assay, FISH, RNA pull-down, and RIP experiments were utilized to evaluate the relationship between circASH2L, miR-525-3p, and MTUS2. Additionally, experiments were conducted to explore the impact of m6A modification on circASH2L expression, including RNA stability assay, m6A RNA immunoprecipitation assay (MeRIP), and Co-IP experiments.
RESULTS: We found that circASH2L was downregulated in HCC tissues and the downregulation of circASH2L was significantly correlated with malignant characteristics as well as poor overall survival of patients with HCC. CircASH2L was found to inhibit cells growth, migration and invasion as well as tumorigenesis and metastasis in vivo. Mechanistically, we established that circASH2L directly interacted with miR-525-3p to enhance MTUS2 expression, subsequently leading to tumor suppression. Moreover, the influence of circASH2L on tumor suppression was attenuated by increasing miR-525-3p levels, and MTUS2 was recognized as an essential intermediary in circASH2L-induced tumor suppression. Additionally, N6-methyladenosine (m6A) modification was identified in circASH2L. Our data suggested that METTL3 was responsible for mediating m6A methylation of circASH2L, ultimately regulating circASH2L expression through the promotion of its degradation. These findings collectively highlight the role of circASH2L as a tumor suppressor through a unique circASH2L/miR-525-3p/MTUS2 axis, shedding light on the significance of m6A modification in regulating circASH2L function.
CONCLUSION: The work emphasizes circASH2L as a promising therapeutic target for treating HCC, offering new insights into the role of circRNAs in HCC development.
OBJECTIVE: Finding events of interest is a common task in biomedical signal processing. The detection of epileptic seizures and signal artefacts are two key examples. Epoch-based classification is the typical machine learning framework to detect such signal events because of the straightforward application of classical machine learning techniques. Usually, post-processing is required to achieve good performance and enforce temporal dependencies. Designing the right post-processing scheme to convert these classification outputs into events is a tedious, and labor-intensive element of this framework.
METHODS: We propose an event-based modeling framework that directly works with events as learning targets, stepping away from ad-hoc post-processing schemes to turn model outputs into events. We illustrate the practical power of this framework on simulated data and real-world data, comparing it to epoch-based modeling approaches.
RESULTS: We show that event-based modeling (without tailored post-processing) performs on par with or better than epoch-based modeling with extensive post-processing.
CONCLUSION: These results show the power of treating events as direct learning targets, instead of using ad-hoc post-processing to obtain them, severely reducing design effort. Significance The event-based modeling framework can easily be applied to other event detection problems in signal processing, removing the need for intensive task-specific post-processing.
1383004 Abrasive compositions COLGATEPALMOLIVE CO 25 May 1972 [3 June 1971] 8455/74 Divided out of 1383003 Heading C4V [Also in Division A5] Abrasive agglomerates suitable for cleaning teeth are produced by (a) dry mixing thermoplastic particles having a mean diameter between - 100 and 1000 Á and abrasive particles having a mean diameter between 0À1 and 10 Á and a Mohs hardness of at least 2, (b) tumbling the mixture whilst maintaining it at a temperature above the softening point of the thermoplastic and (c) cooling the mixture. Between steps (b) and (c) the mixture may be screened to remove fine particles and the agglomerates reheated before cooling. The products usually comprise a core of thermoplastic material with the abrasive concentrated in the surface. Some cores may be hollow. Thermoplastics specified include polythene, α-methyl styrene-vinyl toluene copolymer, gums, gels, paraffins and carnauba wax. Abrasives specified include zirconium silicate, silica, stannic oxide, feldspar, topaz, calcium silicate, silicon carbide, pumice, alumina, ilmenite, haematite, titanium dioxide, dicalcium phosphate dihydrate, calcium carbonate and ground glass.
Due to the increasing prevalence of childhood obesity and overweight, health problems may begin to appear at an early age. Overweight and obese people are at risk for medical conditions that can lead to greater morbidity and mortality. Lack of physical activity is a well-known risk factor for obesity and the relationship between them has been supported by many studies. It has also been reported by studies that obesity affects respiratory parameters. In overweight and obese adolescents, a relationship is likely between the affected respiratory parameters and the weakened core region. There are not enough studies on this subject in the literature. Therefore, the aim of the study is to examine the physical activity level, core performance, anthropometric measurements and peak expiratory flow in overweight and obese adolescents in comparison with normal weight adolescents.