anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The congenital Zika syndrome (CZS) has been characterized as a set of several brain changes, such as reduced brain volume and subcortical calcifications, in addition to cognitive deficits. Microcephaly is one of the possible complications found in newborns exposed to Zika virus (ZIKV) during pregnancy, although it is an impacting clinical sign. This study aimed to investigate the consequences of a model of congenital ZIKV infection by evaluating the histopathology, blood-brain barrier, and neuroinflammation in pup rats 24 h after birth, and neurodevelopment of the offspring. Pregnant rats were inoculated subcutaneously with ZIKV-BR at the dose 1 × 107 plaque-forming unit (PFU mL-1) of ZIKV isolated in Brazil (ZIKV-BR) on gestational day 18 (G18). A set of pups, 24 h after birth, was euthanized. The brain was collected and later evaluated for the histopathology of brain structures through histological analysis. Additionally, analyses of the blood-brain barrier were conducted using western blotting, and neuroinflammation was assessed using ELISA. Another set of animals was evaluated on postnatal days 3, 6, 9, and 12 for neurodevelopment by observing the developmental milestones. Our results revealed hippocampal atrophy in ZIKV animals, in addition to changes in the blood-brain barrier structure and pro-inflammatory cytokines expression increase. Regarding neurodevelopment, a delay in important reflexes during the neonatal period in ZIKV animals was observed. These findings advance the understanding of the pathophysiology of CZS and contribute to enhancing the rat model of CZS.
The invention discloses a construction method, an intervention target and application of a parent osteoarthritis animal model. The animal model is constructed by the steps that an adult male rat is subjected to gastric lavage by caffeine (60 mg/kg.d,2 months) before pregnancy, and then is mated with a female adult rat to obtain a offspring rat. These offspring rats exhibited dysplasia of articular cartilage and developed an osteoarthritis-like phenotype after long runs given a long distance in adulthood. On this model of parent osteoarthritis, it was found that increased methylation level and decreased expression of the promoter region of the imprinting gene Plagl1 in the articular cartilage of offspring rats mediated inhibition of tgfβ signaling pathway and cartilage matrix synthesis disorder. Furthermore, intervention in Plagl1 expression may partially ameliorate the articular cartilage matrix dyssynthesis and the osteoarthritis-like phenotype. Therefore, the model established by the invention has important significance for clarifying the occurrence mechanism of the parent osteoarthritis, determining the intervention target and early prevention and treatment application.
FIELD: medicine, phytotherapy, pharmacy. SUBSTANCE: invention relates to preparing medicinal agents from vegetable raw. Proposed antiburning agent comprises Iris pseudacorus roots in the ratio raw : : oil = 1:24. In proposed method of preparing of antiburning agent involving infusion of dried vegetable raw with unrectified vegetable oil followed by filtration Iris pseudacorus ground roots are used as raw in the ratio raw : oil = 1:24 and infusion is carried out in darkness for 14 days. Proposed antiburning agent can be used for treatment of sluggish burns, wounds, cuts, irritation, cracks and intertrigos on skin, erosion, furuncles, wrinkles (among them, in plastic surgery for post-operation skin healing) and in catarrhal diseases (angina, cold). Except for, the claimed composition is used as analgetic and antihemorrhagic agent. EFFECT: improved method of preparing, valuable medicinal properties. 2 cl, 5 ex
Risperidone tablets given during the screening period to check for sensitivity. Placebo administered by subcutaneous injection on Days 1 and 29 for a total of two injections.
Using findings from prior research, the investigators will design a manualized training protocol (EMIT) for establishing generalized imitation in autistic children that supervised behavior therapists can implement with a high degree of fidelity. The EMIT protocol will serve as a guide for behavior therapists to help them deliver high-quality, empirically derived imitation training to autistic children. The investigators will conduct a small pilot study to evaluate the effects of EMIT on the emergence of generalized imitation with young autistic children. Single-case experimental design and a 2x2 group design will be used. A multiple baseline across participants design is a single-case design that is common in imitation research with this population. In short, the start of the intervention is stagged across participants to systematically assess the effects of the intervention on each participant's behavior. In this experiment, confirmation that EMIT is responsible for any observed effects will be obtained when changes in each participant's behavior (i.e., correct imitation of novel responses) occur when, and only when, the intervention is introduced. The 2x2 design entails the assignment of participants to an intervention group and a waitlist control group. Participants will be matched across the two groups using the scores and information obtained during the screening process. Participants assigned to the EMIT group will receive the intervention immediately. Participants in the waitlist control group will begin participating in the research sessions when their assigned matched study participant has completed his/her participation in the sessions.
The present invention relates to a multifunctional molecule which is capable of initiating first and/or second strand DNA synthesis of a retroviral RNA genome or derivatives thereof. The multifunctional molecule comprises a first part complementary to a part of the retroviral RNA genome or derivatives thereof. A second part of the multifunctional molecule comprises genetic elements and/or labels. The genetic elements may be gene cassettes for the expression of proteins, peptides or polypeptides or for example functional RNA elements such as shRNA, siRNA, miRNA and the like. The multifunctional molecule represents a novel tool for insertion of genes into host cell genomes. The present invention therefore relates to the field of gene delivery and methods employed therefore.
The arms of the study involves determining the haplotype of individuals enrolled. Then participants were divided into two groups based on their genotype. The groups include a genotype with an EGT alle and a group of genotype without an EGT alle. All subjects first took a low dose of DCA 2.5ug/kg for 5 days then wait 30 days and take a therapeutic dose of DCA 25mg/kg for 5 days On the first day and on the 5th day of taking DCA kinetics were be done. A total of 16 blood samples were obtained through an intravenous catheter. Urine collection will also occur.

Population pharmacogenetic analysis of MAI allelic frequencies and the GC or LC-MS/MS techniques for blood or urinary metabolites were used in this investigation. Pharmacokinetic data was used to determine metabolism rate of DCA for each allele
The invention discloses a preparation used for treating chronic endometritis. The preparation is prepared from, by weight, 6 to 9 parts of radix bupleuri, 5 to 13 parts of root of common oxyspora, 7 to 10 parts of seedling of mapleleaf excoecaria, 9 to 13 parts of gentiana davidii Franch., 5 to 11 parts of Livistona chinensis (Jacq.)R. Br. Seed, 7 to 12 parts of cacumen biotae, 4 to 7 parts of edible fat made from milk, 6 to 10 parts of herb of manystem stonecrop, 8 to 13 parts of herba houttuyniae, 5 to 10 parts of rotala rotundifola (Buch.-Ham.) Koehne, 7 to 13 parts of flos sophorae, 9 to 12 parts of scabrous doellingeria rhizome and root, 4 to 10 parts of herb of cuneate lespedeza, 2 to 6 parts of herb of tall rattlesnake plantain, 7 to 11 parts of tripterospermum cordatum, and 6 to 12 parts of root of bodinier beautyberry. The preparation is capable of replenishing blood and nourishing yin, promoting qi circulation to relieve pain, and promoting blood circulation to remove blood stasis, and possesses excellent curative effects on chronic endometritis symptoms such as pelvie cavity pain, leukorrhagia, and hypermenorrhea; effects are achieved quickly; treatment course is short; and cure rate is high.
The depletion of visceral and subcutaneous adipose tissue (AT) during chemotherapy significantly correlates with diminished overall survival and progression-free survival. Despite its clinical significance, the intricate molecular mechanisms governing this AT loss and its chemotherapy-triggered initiation remain poorly understood. Notably, the evaluation of AT remodeling in most clinical trials has predominantly relied on computerized tomography scans or bioimpedance, with molecular studies often conducted using animal or in vitro models. To address this knowledge gap, a comprehensive narrative review was conducted. The findings underscore that chemotherapy serves as a key factor in inducing AT loss, exacerbating cachexia, a paraneoplastic syndrome that significantly compromises patient quality of life and survival. The mechanism driving AT loss appears intricately linked to alterations in AT metabolic remodeling, marked by heightened lipolysis and fatty acid oxidation, coupled with diminished lipogenesis. However, adipocyte stem cells' lost ability to divide due to chemotherapy also appears to be at the root of the loss of AT. Notably, chemotherapy seems to deactivate the mitochondrial antioxidant system by reducing key regulatory enzymes responsible for neutralizing reactive oxygen species (ROS), thereby impeding lipogenesis. Despite FDG-PET evidence of AT browning, no molecular evidence of thermogenesis was reported. Prospective investigations unraveling the molecular mechanisms modulated in AT by chemotherapy, along with therapeutic strategies aimed at preventing AT loss, promise to refine treatment paradigms and enhance patient outcomes.
Participants randomized to the control group will receive a dose of placebo enterally twice daily for 5 days (a total of 10 doses). The placebo pills will be as similar as possible to the hydroxychloroquine pills to ensure blinding.
BACKGROUND: In 2015 our centre introduced a nurse-led renal cell cancer follow-up protocol and clinic for patients who have undergone partial or radical nephrectomy for organ-confined kidney tumours. The main aims of this clinic were to improve healthcare efficiency and standardize follow-up processes.
OBJECTIVES: The primary objective was to assess the effectiveness of a nurse-led renal cell cancer follow up clinic in regard to surveillance protocol compliance and the timely identification and appropriate management of recurrences. A secondary objective was to evaluate this locally developed follow up protocol against the current European Association of Urology (EAU) guidelines surveillance protocol.
PATIENT AND METHODS: All patients who underwent a partial or radical nephrectomy between 2015 and 2021 at a single Western Australia institution for a primary renal malignancy were included. Data was collected from local clinical information systems and protocol adherence, recurrence characteristics and management were assessed. The current EAU guidelines were applied to the cohort to assess differences in risk-stratification and theoretical outcomes between the protocols.
RESULTS: After a mean follow up period of 31.2 months (range 0-77 months), 75.5% (185/245) of patients had all follow up imaging and reviews within 1 month of the timeframe scheduled on the protocol. 17.1% (42/245) had a delay in their follow up of more than a month at some stage, 5.7% (14/245) did not attend for follow up but had documented attempts to facilitate their compliance, and 0.4% (1/245) were lost to follow up with no evidence of attempted contact. 15.5% (38/245) of patients had recurrence of malignancy detected during follow up and these were all discussed in a multi-disciplinary team (MDT) meeting. The recurrence rate was 2.5% (3/119) for low risk, 17.7% (14/79) for intermediate risk, and 44.7% (21/47) for high risk patients when they were re-stratified according to EAU risk categories. No recurrences were detected through ultrasound (USS) or chest x-ray (CXR) in this cohort and our protocol tended to place patients in higher risk-stratification groups as compared to current EAU guidelines.
CONCLUSION: Nurse-led renal cell cancer follow up is a safe, reliable and effective clinical framework that has significant benefits in regard to resource utilization. USS and CXR are ineffective in detecting recurrence and Computerized tomography (CT) should be considered the imaging modality of choice for this purpose. The EAU surveillance protocol appears superior to our protocol, and we have therefore transitioned to the EAU guideline protocol going forward.
Human tissue plasminogen activator (t-PA) mutant (I) is produced by recombinant cells and is resistant to specific enzymatic cleavage. (I) is esp. in single-chain form, stabilised by site-directed mutagenesis at a 2-chain cleavage site. Partic. the matural Arg at position 275 is replaced by Gly or Glu, or Ila at position 276 is replaced. Also new are (1) DNA sequences coding for (I); (2) expression vectors able to express (I) and (3) microorganisms and cell cultures transformed with these vectors. A native t-PA gene, contg. the sequence to be mutated, is inserted into the phage M13mp8, and the single-strand form of the prod. annealed to a synthetic oligonucleotide, co-ng. 1 or more triplets coding for the amino acid(s) to be substd. forming a double-strand region. Expression vectors contg. the new DNA sequences can be expressed in E.coli or partic. cultures of Chinese hamster ovary (using vectors which include the SV40 origin of replication as promoter).
PROBLEM TO BE SOLVED: To obtain the subject preparation for external use, enabling topical narcosis only by the adhesion of the preparation by adding a moisturizing agent, a topical anesthetic, an Al compound and water to a copolymer produced from N-vinylacetamide and a monomer having a carboxyl (salt) group as main monomers. SOLUTION: This topical narcotic for external use is obtained by adding 10-70 wt.% of a moisturizing agent (e.g. polyethylene glycol), 0.01-5 wt.% of a topical anesthetic (e.g. lidocaine), 0.001-5 wt.% of an aluminum compound (e.g. aluminum glycinal) and 10-70 wt.% of water, wherein the total amount of the water and the moisturizing agent is 65-99 wt.%. The topical narcotic is excellent in shape retainability and percutaneous absorbability, and easily gives a topical narcotic action only by the adhesion of the preparation.
A Phase 2 Single-Arm Clinical Study in Relapsed Mantle Cell Lymphoma after Prior Therapy

The safety and efficacy of bortezomib in relapsed or refractory mantle cell lymphoma were evaluated in an open-label, single-arm, multicenter study (NCT00063713) of 155 patients with progressive disease who had received at least one prior therapy. The median age of the patients was 65 years (42, 89), 81% were male, and 92% were Caucasian. Of the total, 75% had one or more extra-nodal sites of disease, and 77% were Stage 4. In 91% of the patients, prior therapy included all of the following: an anthracycline or mitoxantrone, cyclophosphamide, and rituximab. A total of thirty seven percent (37%) of patients were refractory to their last prior therapy. An intravenous bolus injection of bortezomib 1.3 mg/m2/dose was administered twice weekly for two weeks on Days 1, 4, 8, and 11 followed by a ten-day rest period (Days 12 to 21) for a maximum of 17 treatment cycles.Patients achieving a CR or CRu were treated for four cycles beyond first evidence of CR or CRu. The study employed dose modifications for toxicity [see Dosage and Administration  (2.4, 2.5)] . 

Responses to bortezomib are shown in Table 13. Response rates to bortezomib were determined according to the International Workshop Response Criteria (IWRC) based on independent radiologic review of CT scans. The median number of cycles administered across all patients was four; in responding patients the median number of cycles was eight. The median time to response was 40 days (range 31 to 204 days). The median duration of follow-up was more than 13 months.
For patients not adequately controlled on GLUCOVANCE, a thiazolidinedione can be added to GLUCOVANCE therapy. When a thiazolidinedione is added to GLUCOVANCE therapy, the current dose of GLUCOVANCE can be continued and the thiazolidinedione initiated at its recommended starting dose. For patients needing additional glycemic control, the dose of the thiazolidinedione can be increased based on its recommended titration schedule. The increased glycemic control attainable with GLUCOVANCE plus a thiazolidinedione may increase the potential for hypoglycemia at any time of day. In patients who develop hypoglycemia when receiving GLUCOVANCE and a thiazolidinedione, consideration should be given to reducing the dose of the glyburide component of GLUCOVANCE. As clinically warranted, adjustment of the dosages of the other components of the antidiabetic regimen should also be considered.
Studies assessing the use of ground-penetrating radar (GPR) for locating unmarked human graves commonly use pigs as proxies, with recent concerns about the adequacy of pigs as substitutes for humans. Also, there is little agreement on how to identify and describe GPR signals associated with graves. Hence, this project's aim is to compare GPR signals acquired over simulated clandestine graves with pig and human remains. We established human, pig, and control graves at the REST[ES] human decomposition facility in May 2022 and monitored the graves over 17 months using a 250 MHz antenna GPR system. Our results showed the presence of perturbed and V-shaped reflectors, diffraction hyperbolas, and reflectors with amplitude loss at depth between 0.6 and 0.75 m in the radargram for graves with human and pig remains. We corroborate recent studies which concluded that the use of proxies is a viable alternative to human cadavers. The observed radar signatures were classified into five key patterns, which are characteristic of similar data collected with 250 MHz above graves reported in the literature. These classes are: V-shaped dipping reflections from grave walls (class A), small hyperbolic reflections superimposed onto a near-linear reflector (class B), hyperbolic reflections from remains within the grave (class C), new high-amplitude reflection patterns (class D) and significant loss or interruption of reflections (class E). Our proposed classification can help streamline future investigations where the goal is to interpret burials within large GPR datasets and provide language to communicate these results to the broader scientific community.
Coronary artery bypass graft (CABG) is the process of creating a bridge (grafting) to narrowed or clogged coronary arteries using artery and/or vein grafts. Discharge training has many effects such as pain management, reduction of home care visits, reduction of re-admissions to the hospital, acceleration of the recovery process, improvement of self-care agency, reduction of cost, reduction of anxiety level, enhancement of coping and adaptation, and patient satisfaction. Self-care, coping and adaptation remain important in promoting health. Self-care is defined as the decisions and practices made by individuals, who face health concerns, to cope with these concerns, improve their health, and enhance their adaptation. With these improved decisions and practice skills, patients can protect their health more actively. Besides self-care, coping and adaptation are other important issues in patient follow-up. The concept of coping and adaptation is defined as the cognitive and behavioral efforts of the individual to eliminate the necessities and obligations that occur in the inner and outer world, take them under control, and reduce the tension. These efforts may differ according to variables such as family support and spirituality. Patients who are insufficiently informed and not followed up in the postoperative period experience deficits in self-care and difficulties in coping and adaptation. Today, with the increase in the technology use, patient counseling by telephone can be provided for patient follow-up at home, monitoring drug side effects, counseling, sudden situations, appointment reminder, evaluation of the effectiveness of discharge training, determining training needs, performance evaluation, providing communication between hospital and home, increasing participation in training, improving self-care, increasing quality of life, ensuring coping and adaptation. Postoperative care outcomes and the patient's medical condition can be improved by ensuring continuity in telephone counseling. Postoperative mobile health applications are important in terms of evaluating changes, that may occur in the home environment, on time. Today, the rapid development of medicine and technology and the development of products that facilitate monitoring patients can help individuals who have undergone CABG surgery through telephone counseling and patient training. Training and telephone counseling services may reduce the number of hospital admissions, increase self-care agency, improve the quality of life, and enhance coping and adaptation.
<P>PROBLEM TO BE SOLVED: To provide an external preparation for decreasing fat and a fat decreasing apparatus, both locally decreasing fat by a simple means such as sticking/coating, etc.  <P>SOLUTION: The external preparation for decreasing fat contains at least one of lipolysis components such as capsaicin, its homologues, its derivatives, or a nonylic acid vanillylamide and of adipogenesis suppressive components. The external preparation includes an agent drug including a base material and a drug layer which is formed on the base material, contacts with skin, and includes a lipolysis component and/or an adipogenesis suppressive component. The base material can include a material capable of transmitting ultrasonic sound, a perforate or a large number of small openings, and an ultrasonic acoustic binder which makes ultrasonic wave impregnated into the base material to be transmissive. When the drug layer of the attachable external preparation contacts with a skin or is applied to the skin as a coated external preparation containing a lipolysis component and/or an adipogenesis suppression component, a physical stimulus granting means imparting physical irritation from the body surface can be used at the same time. The physical stimulus granting means for the living body is at least one of ultrasonic wave, electromagnetic wave, or mechanical vibration.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Pain and depression comorbidity affects patients' physical and mental health, as well as quality of life. Comorbid depressive symptoms in cancer pain have a severe impact on the recognition and treatment of pain. Similarly, cancer pain patients with depression are inclined towards more despair and greater impairment. The mechanisms responsible for the comorbid depressive symptoms in bone cancer pain (BCP) have not been fully delineated. Here, it was reported that the implantation of carcinoma cells into the femoral cavity of mice led to the upregulation of major histocompatibility complex class I (MHC-I) in the hippocampus. This was associated with the activation of microglial signaling pathway mediated by the triggering receptor expressed on myeloid cells 2 protein (TREM2) and DNAX-activating protein of 12 kDa (DAP12). Pain and depression-like behaviors were reversed by the knockdown of hippocampal MHC-I via a lentiviral vector harboring ribonucleic acid interference (RNAi) sequence. Moreover, MHC-I knockdown exhibited a marked reduction in the expression of TREM2 and DAP12. These results suggested that hippocampal MHC-I was involved in BCP and depression comorbidity via upregulating the signals mediated by TREM2/DAP12 in microglia. The suppression of MHC-I could be a potential therapeutic target for BCP.