anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The 12-week resistance training program consisted of three supervised sessions per week, each lasting approximately 55-60 minutes. Sessions were structured as follows: 5-7 minute dynamic warm-up, 35-40 minutes of resistance training, and 4-5 minutes of stretching for active recovery. Participants were paired based on similar strength fitness levels and progressed according to the principle of periodized progressive overload.
Each subject will receive both treatments A and B in either of period 1 or 2 with a washout period of 28 days between treatment periods. Subjects will receive the study treatments under fasting conditions.
<P>PROBLEM TO BE SOLVED: To provide a server for integrally managing medical data of a plurality of types of data formats without causing information degradation.  <P>SOLUTION: An integrated management server 30 receives DICOM reference image data from an image management server 50, and receives HL7-compliant inspection data from an inspection management server 70, and receives HL7-compliant pathology diagnostic data from a pathology department information management device 90. The integrated management server 30 analyzes the received medical data, and generates key information which is common to each of the data formats. The integrated management server 30 adds the key information to the medical data. The integrated management server 30 stores the medical data, and integrally manages the medical data as integrated management medical data based on the added key information.  <P>COPYRIGHT: (C)2010,JPO&INPIT
In a process for the production of dental prostheses by the powder-liquid process the liquid comprises an acrylic and/or a methacrylic acid ester containing at least one free hydroxyl group in the molecule, methyl methacrylate and a free-radical producing polymerization catalyst, e.g. benzoyl peroxide.  Powders used are polymethyl methacrylate, a copolymer of methyl methacrylate and ethyl acrylate, or mixtures of the two.  Suitable free hydroxyl group containing esters are hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, dihydroxypropyl methacrylate, diethylene glycol monomethacrylate, glycerine monoacrylate, and glycerine monomethacrylate. Cross-linking agents, e.g. glycol dimethacrylate may be included in the liquid. The powder-liquid mixture is formed into dental protheses in the conventional manner.
Administer infliximab intravenously to patients with DVB aneurysms (3 mg/kg at 0, 3 and 7 weeks, then at 8-week intervals x 7) for a total of 12-months. Patients will undergo MR imaging at 0, 12, and 24-month time points.
Intervention Group (Group 2; Pamphlet and video Only). Parents in this intervention group will receive a pamphlet containing evidence-based information on needle pain management and a pamphlet summarizing memory reframing principles. The pamphlet will have a link to a video summarizing the memory reframing strategies.
Blindness affects millions of people around the world. A promising solution to restoring a form of vision for some individuals are cortical visual prostheses, which bypass part of the impaired visual pathway by converting camera input to electrical stimulation of the visual system. The artificially induced visual percept (a pattern of localized light flashes, or 'phosphenes') has limited resolution, and a great portion of the field's research is devoted to optimizing the efficacy, efficiency, and practical usefulness of the encoding of visual information. A commonly exploited method is non-invasive functional evaluation in sighted subjects or with computational models by using simulated prosthetic vision (SPV) pipelines. An important challenge in this approach is to balance enhanced perceptual realism, biologically plausibility, and real-time performance in the simulation of cortical prosthetic vision. We present a biologically plausible, PyTorch-based phosphene simulator that can run in real-time and uses differentiable operations to allow for gradient-based computational optimization of phosphene encoding models. The simulator integrates a wide range of clinical results with neurophysiological evidence in humans and non-human primates. The pipeline includes a model of the retinotopic organization and cortical magnification of the visual cortex. Moreover, the quantitative effects of stimulation parameters and temporal dynamics on phosphene characteristics are incorporated. Our results demonstrate the simulator's suitability for both computational applications such as end-to-end deep learning-based prosthetic vision optimization as well as behavioral experiments. The modular and open-source software provides a flexible simulation framework for computational, clinical, and behavioral neuroscientists working on visual neuroprosthetics.
A total of 668 consecutive patients (77.2% male, mean age 61.3±13.3 years) with STEMI underwent primary PCI were analyzed. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or by antihypertensive prescription. Type 2 diabetes was defined by hypoglycemic agents or insulin prescription, fasting plasma glucose ≥126 mg/dL, glycosylated hemoglobin (HbA1c) ≥6.5%, or known but untreated hyperglycemia. Dyslipidemia was defined by total cholesterol ≥240 mg/dL, LDL cholesterol ≥130 mg/dL, HDL cholesterol\<40 mg/dL, triglycerides ≥200 mg/dL, and/or by lipid-lowering prescription.STEMI was defined as typical chest pain lasting for \>30 min within the last 24h, with electrocardiographic findings of ST elevation \>1 mm in at least two consecutive leads or new-onset left bundle branch block, and 2-fold elevation of serum levels of troponin-I or the creatine kinase-MB above the upper normal limit. Obstructive CAD was defined as ≥50% luminal narrowing and the extent of obstructive CAD was categorized according to the number of vessels involved (1, 2, or 3). CI-AKI was defined as increase in serum creatinine of ≥0.5 mg/dl or 25% relative rise, within 48h after index procedure. HLI was defined as ≥2-fold increase of serum aspartate transaminase above upper normal limit at admission. Patients were divided into four groups according to their CI-AKI and HLI states. Major adverse cardiovascular and cerebrovascular events (MACCE) defined as composite of all-cause mortality, non-fatal MI, non-fatal stroke, ischemia-driven target lesion revascularization and target vessel revascularization were recorded. Continuous data were expressed as a mean value ± standard deviation or median value (interquartile range) as appropriate. Categorical data were presented as a percentage or absolute number. Analyses of continuous data were performed using analysis of variance (ANOVA) test or Kruskal-Wallis test as appropriate and analyses of categorical data were performed using chi-square test to assess differences among the four groups. Cumulative event rates as a function over time were estimated using the Kaplan-Meier method.
<P>PROBLEM TO BE SOLVED: To provide a sleep-introducing drug having an excellent therapeutic effect on insomnia that remarkably solves problems of oral sleeping drugs (or sleep-introducing drugs).  <P>SOLUTION: The nasal sleep-introducing drug contains a medicinal component having a hypnotic function and an antihistamine function and introduces one into sleep by nasal administration (or nasal systemic administration). The medicinal component may be diphenhydramine hydrochloride, chlorpheniramine maleate, promethazine hydrochloride, hydroxyzine hydrochloride, ketotifen fumarate, azelastine hydrochloride or the like. The sleep-introducing drug has an immediate effect even in a low dosage by means of nasal systemic administration. The dosage of the medicinal component is 0.1-50 mg a day for adults.  <P>COPYRIGHT: (C)2010,JPO&INPIT
PURPOSE: This study aimed to investigate the incidence of hyperuricemia in obese individuals with or without metabolic syndrome and assess the impact of sleeve gastrectomy surgery on the amelioration of hyperuricemia and metabolic syndrome.
MATERIALS AND METHODS: A prospective study was conducted on patients with obesity who were candidates for laparoscopic sleeve gastrectomy. These patients were diligently followed for 1 year after the surgical procedure. The assessment of hyperuricemia and metabolic syndrome was carried out both before and one year after the surgery.
RESULTS: A total of 198 patients (30 males and 168 females) underwent sleeve gastrectomy. After 1 year, there was a notable decline in the prevalence of hyperuricemia, decreasing from 77 to 36 cases (a reduction of 46.75%) among females and from 18 to 8 cases (a reduction of 44.44%) among males. Prior to the surgery, 60.6% of patients (120 out of 198) were diagnosed with metabolic syndrome, and 36.7% of these patients exhibited improvements in their metabolic syndrome status. Among individuals with metabolic syndrome, significant enhancements were observed in various anthropometric and laboratory measurements, including reductions in hypertriglyceridemia, hyperuricemia, and hypercholesteremia. A logistic regression analysis revealed that in females, changes in creatinine, glomerular filtration rate (GFR), weight loss, body mass index (BMI), and triglyceride reduction all had a notable impact on the likelihood of recovering from hyperuricemia.
CONCLUSION: These findings underscore the clinical relevance of this surgical intervention in managing obesity-related conditions.
High protein enteral tubefeeding solution. NICE guidelines regarding refeeding syndrome, based on a very cautious refeeding regime reaching estimated calorie and protein needs within 7 days, compared to a protocol at Diakonhjemmet Hospital using a higher starting rate, reaching estimated needs within 3 days.
Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent death, plays a crucial role in diseases such as stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level of ROS has been revealed to be pivotal for the occurrence of pyroptosis, establishing a close relationship between the two. This review primarily focuses on the molecular mechanisms of ROS and pyroptosis in tumors and inflammatory diseases, exploring key proteins that may serve as drug targets linking ROS and pyroptosis and emerging fields targeting pyroptosis. Additionally, the potential future development of compounds and proteins that influence ROS-regulated cell pyroptosis is anticipated, aiming to provide insights for the development of anti-tumor and anti-inflammatory drugs.
NEW MATERIAL:The compound of formula I [X is CH, CF or N; R1 is group of formula II or III (R3 and R4 is H or lower alkyl); R2 is lower alkyl or lower cycloalkyl] and its salt. EXAMPLE:1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-( 1-pyrazolidinyl )-quinoline-3-carbo xylic acid. USE:An antibacterial agent having low toxicity, weak side effect and excellent absorbability and resistant to metabolism. The compound is especially useful as a remedy for infectious disease of urinary tract because of high excretion rate of the compound into urine. PREPARATION:The objective compound can be produced e.g. by reacting the carboxylic acid of formula TV (Y is group which can be substituted with pyrazolidines) or its ester with a pyrazolidine derivative of formula V or VI.
FIELD: organic chemistry, medicine, neurology, pharmacy. SUBSTANCE: invention relates to 1-(3- heteroarylpropyl or prop-2-enyl)-4-benzylpiperidines of the formula (I)   wherein X means oxygen atom, NR 1 , sulfur atom or CH 2 ; Y means CH; Z means CH; Y and X in common can mean C=C; R 1 , R 2 , R 3  mean hydrogen atom; R 4  means fluorine atom. Invention describes also method for preparing these compounds, pharmaceutical composition for treatment and prophylaxis of cerebral disorders based on these compounds and method for preparing pharmaceutical composition. Invention provides preparing new compounds eliciting valuable biological properties. Invention can be used in medicine as medicinal agent for treatment and prophylaxis of cerebral disorders. EFFECT: improved preparing method, valuable medicinal properties of compounds. 6 cl, 1 tbl, 3 ex
PURPOSE:To obtain a blood serum level lowering agent, containing a diglyceride as an active ingredient and having high safety without affecting taste of a food, etc., even in its addition thereto at all. CONSTITUTION:A blood serum level lowering agent containing a diglyceride, e.g. a compound expressed by the formula (two of R<1> to R<3> are acyl derived from a 12-22C saturated fatty acid or unsaturated fatty acid and the rest is H), preferably a compound having an acyl group derived from a 16-20C unsaturated fatty acid as an active ingredient. The aforementioned diglyceride is obtained by transesterification of, e.g. a mixture of fats and oils (e.g. rape seed oil) with glycerol in the presence of an alkali (earth) metallic hydroxide or reacting a lipase with a mixture of a fatty acid or its ester with the glycerol and conducting esterifying reaction.
PURPOSE: Occupational asthma is commonly observed in bakers and confectioners. Endogenous and exogenous risk factors contribute to bakers' asthma. A heightened awareness of this and early diagnosis can be helpful in terms of prevention. The aim of the study was to identify a temporal relationship between the years of training, as well as possible technical, procedural, and individual risk factors for the development of flour-exposure related atopic symptoms such as rhinitis, cough, and rash in young professionals.
METHODS: 127 bakers and confectioner trainees were observed over a one-year period. Two questionnaires served as test instruments. It was investigated whether the rates of atopic symptoms change over the course of a school year and which conditions in the workplace could be responsible for this. Descriptive statistics were used to answer the research questions concerning flour exposure and symptom rates. The Pearson-Chi-Square test was used for testing statistical differences between different groups (e.g. year of training, working conditions).
RESULTS: An increase in rates of self-reported rhinitis, coughing, and rashes throughout the duration of traineeship was shown (e.g. rhinitis of bakers at work: 0% in the first year of training, 20% in the second and 33% in the third year of training). The installation of vapour extraction systems and low-dust transfer of baking agents led to fewer symptoms in the workplace (30% of participants with rhinitis symptoms worked with no installed vapour extraction systems). A medical history of atopy was positively correlated with the occurrence of symptoms.
CONCLUSION: To prevent the development of asthma in bakers, methods to improve occupational health and safety should be developed. Creating low dust working conditions e.g., due to the use of vapour extraction systems should be considered.
<P>PROBLEM TO BE SOLVED: To provide a lipstick production installation by which a lipstick element can be prevented from being damaged carelessly because the lipstick includes a structure stably fixing the lipstick element, and a sliding base in a lipstick element housing can effectively be engaged with the lipstick element.  <P>SOLUTION: The lipstick production installation mainly includes an elastic mold device. The elastic mold device has a molding hole for forming a shape of the lipstick element by being filled, and three or more bent members to be installed in the upper part of the elastic mold device by a movable method. When the bent members moves in the radius direction to face to each other, an opening is formed in the mold member to enable a lipstick material to be filled therein and to form a bottom part of the lipstick element. When the bent members are mutually separated, the lipstick element is exposed to enable the lipstick sliding base to be simply engaged with the bottom part of the exposed lipstick element at any time.  <P>COPYRIGHT: (C)2008,JPO&INPIT
OBJECTIVE: To evaluate the prediction value of Dual-energy CT (DECT)-based quantitative parameters and radiomics model in preoperatively predicting muscle invasion in bladder cancer (BCa).
MATERIALS AND METHODS: A retrospective study was performed on 126 patients with BCa who underwent DECT urography (DECTU) in our hospital. Patients were randomly divided into training and test cohorts with a ratio of 7:3. Quantitative parameters derived from DECTU were identified through univariate and multivariate logistic regression analysis to construct a DECT model. Radiomics features were extracted from the 40, 70, 100 keV and iodine-based material-decomposition (IMD) images in the venous phase to construct radiomics models from individual and combined images using a support vector machine classifier, and the optimal performing model was chosen as the final radiomics model. Subsequently, a fusion model combining the DECT parameters and the radiomics model was established. The diagnostic performances of all three models were evaluated through receiver operating characteristic (ROC) curves and the clinical usefulness was estimated using decision curve analysis (DCA).
RESULTS: The normalized iodine concentration (NIC) in DECT was an independent factor in diagnosing muscle invasion of BCa. The optimal multi-image radiomics model had predictive performance with an area-under-the-curve (AUC) of 0.867 in the test cohort, better than the AUC = 0.704 with NIC. The fusion model showed an increased level of performance, although the difference in AUC (0.893) was not statistically significant. Additionally, it demonstrated superior performance in DCA. For lesions smaller than 3 cm, the fusion model showed a high predictive capability, achieving an AUC value of 0.911. There was a slight improvement in model performance, although the difference was not statistically significant. This improvement was observed when comparing the AUC values of the DECT and radiomics models, which were 0.726 and 0.884, respectively.
CONCLUSION: The proposed fusion model combing NIC and the optimal multi-image radiomics model in DECT showed good diagnostic capability in predicting muscle invasiveness of BCa.
FIELD: biotechnology, medicine, pharmacy, veterinary science. SUBSTANCE: invention proposes the preparation based on genetic engineering gamma-interferon (molecular mass is 16.7 kDa) consisting of 144 amino acid residues and exhibiting high purity. Preparation is obtained by microbiological synthesis followed by chromatography purification. Specific antiviral activity of preparation is 2 x 10IU/mg protein (not less), content of the basic substance is 95% (not less) as monomer and 5% (not above) of dimer. Preparation has biologically inert low-molecular polymeric filling agent-stabilizing agent (polyvinylpyrrolidone or dextran) and salt buffer system, pH = 4.5-7.5; preparation can contain also amino acid argentine, histidine or lysine or its physiologically acceptable salt at amount 0.5-3%, and nonionogenic surface-active substance. Dry preparation can be stored for at least one year without inactivation. EFFECT: high antiviral activity, good stability.
* Temozolomide capsules, USP for oral administration 



-5 mg capsules have opaque white bodies with opaque light green caps. The capsule body is printed with "604" in black ink and the cap is printed with "LP" in black ink.  
-20 mg capsules have opaque white bodies with opaque yellow caps. The capsule body is printed with "605" in black ink and the cap is printed with "LP" in black ink.  
-100 mg capsules have opaque white bodies with opaque pink caps. The capsule body is printed with "606" in black ink and the cap is printed with "LP" in black ink.  
-140 mg capsules have opaque white bodies with opaque blue caps. The capsule body is printed with "607" in black ink and the cap is printed with "LP" in black ink.  
-180 mg capsules have opaque white bodies with opaque swedish orange caps. The capsule body is printed with "608" in black ink and the cap is printed with "LP" in black ink.  
-250 mg capsules have opaque white bodies with opaque white caps. The capsule body is printed with "609" in black ink and the cap is printed with "LP" in black ink.
Our previous article has reported the method of colon TET. However, the investigators found that it was difficult to find the cavity because of the concentration of intestinal folds caused by the tube pulling after insertion of TET. It is well known that transparent cap-assisted colonoscopy is easier to flatten the semilunar folds and improve mucosal exposure. Here the investigators test the hypothesis that using transparent cap-assisted colonoscopy significantly decreases the second cecal intubation time which not only improve work efficiency, but also saves patients' anesthesia time and cost. Thus, the investigators design a prospective multicenter, randomized controlled trial. The aim of this study was to evaluate the methodology, efficiency, feasibility and safety of using transparent cap-assisted endoscopy for colon TET implantation.
Dose-finding study with 4 subjects per dose and a maximum of 40 parturients.To identify the dose to give for reaching the ED95 (effective dose for 95% subjects), Hyperbaric prilocaine 2%, associated with sufentanyl, will be administrated at the dose initial of 45 mg in the cohort 1 (4 subjects), then the dose will be adjusted in the next cohorts using the Continual Reassessment Method (CRM). Possible dose levels are 30, 35, 40, 45, 50, 55mg.
To evaluate the effect of different surgical approaches on the prognosis of patients with hypertensive intracerebral hemorrhage, hypertensive patients who met the diagnostic criteria of American guidelines for the treatment of adult spontaneous intracerebral hemorrhage (2015) were selected. The time from onset to admission was less than 8 hours. Blood routine examination, liver and kidney function, coagulation system, infectious diseases and other examinations were performed before operation, with emergency surgical indications, They were divided into two groups: transfrontal keyhole approach and transoccipital keyhole approach. Emergency endoscopic hematoma removal was performed. The patients were systematically evaluated and followed up at 1 week, 1 month, 3 months, 6 months and 12 months after operation to observe the improvement of consciousness, GCS score, postoperative rebleeding (appearance, bleeding volume, location, broken into ventricle, etc.), The prognosis was evaluated by ADL score, GCS score, gos score, modified Rankin scale, Mrs scale and ICH Score (GCS, hematoma volume, intraventricular hemorrhage, infratentorial source, patient age, etc.).
The invention provides cefdinir acid double salt. The double salt is obtained by a reaction among the cefdinir, acid and an alkali metal element or ammonium (including ammonia) compound or acid salt. When the acid or the acid salt is sulfate radical, cefdinir sulfuric acid double salt is obtained, and when the acid or the acid salt is phosphate radical, cefdinir phosphoric acid double salt is obtained. The method has the advantages of reasonable design, stable process and good production feasibility. The cefdinir acid double salt has the obvious advantages of good solubility, high bioavailability and the like, and can be prepared into oral solid preparation and injection to further exert advantages of wide antibacterial spectrum, strong activity and good drug effect of the cefdinir. The cefdinir acid double salt has the structural general formula.