anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Recurrence of disc herniation is a prevalent late-term complication among patients surgically treated for lumbar disc herniation. Differential diagnosis between recurrent disc herniation and granulation tissue can be achieved through signal intensity measurements on T2-weighted MRI examinations. This study aims to examine cases operated on for recurrence of lumbar disc herniation, assessing those presenting with either disc recurrence or granulation tissue. The objective is to demonstrate that differential diagnosis can be facilitated through signal intensity value measurements and radiological findings in MRI examinations of patients with disc herniation recurrence and granulation tissue.
METHODS: Analysis involved reviewing lumbar MRI T2 sequences of patients operated on with a presumptive diagnosis of lumbar disc herniation recurrence. Mean T2 signal intensity values in preoperative MRI images of cases with disc herniation recurrence and granulation tissue were examined and recorded on the Picture Archiving and Communication System. Mean T2 signal intensity values of recurrent disc herniation and granulation tissue were then compared.
RESULTS: Among the patients who underwent surgery, disc herniation recurrence was observed in 135 cases, while granulation tissue was found in 12 patients (8.89 %). The preopreative mean T2 signal intensity value for disc herniation was recorded as 54.82 ± 2.42, whereas the mean T2 signal intensity value for granulation tissue was 205.96 ± 5.62.
CONCLUSIONS: T2 sequences in MRI examinations offer the clearest evaluation of disc herniations. Mean T2 signal intensity value measurements conducted on the PACS system can aid in differentiating between recurrent disc herniation and granulation tissue. These findings serve to inform surgical protocols during the preoperative phase.
The present invention is generally directed toward the use of Factor VIIa (FVIIa) to achieve haemostasis in certain situations when the haemostatic system including the coagulation cascade and platelets is functioning normally. Thus FVIIa may be used to potentiate, or enhance, the normal haemostatic system in situations where bleeding can be foreseen and where prevention or treatment of such bleeding in needed or desirable. In spite of a normal haemostatic system, extensive bleedings may occur in association with surgery or other types of tissue damage, e.g. severe trauma. FVIIa may also be used when the bleeding is diffuse and poorly respondign to current haemostatic techniques and therapies (e.g. haemorrhagic gastritis and profuse uterine bleeding). FVIIa may also be suitable for the treatment of bleedings occurring in organs with limited possibility for mechanical haemostasis such as brain, inner ear region, eyes as well as in association with the process of taking biopsies from various organs and in laparoscopic surgery. According to the present invention, Factor VIIa may also be used in association with bleedings in patients who have been given anticoagulant therapy or in such patients in case of a need for re-establishing of a normal haemostasis (reversing the anticoagulant effect).
Viral infections are an important cause of morbidity and mortality in hospitalized patients. Viruses have also been identified as the probable cause of a number of malignancies including hepatocellular carcinoma and cervical carcinoma. The purpose of this study is to identify novel viruses (or known viruses) that are associated with diseases whose etiology is unknown. Blood samples, body fluids, or discarded tissues (e.g. previous biopsy or autopsy material) saliva swabs, nasopharyngeal swabs, skin biopsies, or mucosal biopsies will be obtained from patients with clinical syndromes or diseases whose etiology is unknown. Highly sensitive assays using the polymerase chain reaction will be performed to attempt to identify novel or known viruses that might be present in the blood, body fluids, or tissues. Knowledge gained from this study could provide important insights into the cause of diseases whose etiology is presently unknown.
The present invention relates to a method of purifying mammalian hematopoietic stem cells from a bone marrow cell population. The present invention also relates to a method of separating cycling HSCs from quiescent HSCs in a purified mammalian HSC sample. Further, the invention relates to a method of identifying an agent which is a fluorescent, vital dye which is lipophilic for use in purifying mammalian HSCs. The present invention also relates to a method of transplanting bone marrow in a mammalian host, such as a human, comprising introducing into the host the purified HSCs described herein. The invention further relates to a method of in vivo administration of a protein comprising transfecting a purified HSC with a construct comprising DNA which encodes a protein of interest and then introducing the stem cell into the host where the protein of interest is expressed. The present invention also relates to hematopoietic stem cells purified using the methods described herein.
Beverages are provided and administered for producing LIS samples containing cells exfoliated from throughout the gut in sufficient numbers and free of interfering substances such as formed fecal particles for chemical assays and biologic assays for nucleic acid sequence information, and medical diagnosis. A kit is also provided for use by patients without assistance to produce a LIS sample suitable for analysis. A collection kit employs a sequence of the beverages and other ingested substances to produce preserved cells for medical diagnosis, allowing cytologic analysis of the LIS for diagnosis of foregut and hindgut disease. A preliminary cathartic lavage is used to cleanse a patient's digestive tract; at least one stool induced by the preliminary cathartic lavage is collected; and a final cathartic lavage is used to exfoliate and preserve cells from a patient's digestive tract. Time release capsules containing a cathartic medicament can also be used after completing preliminary lavage administration. The kit also provides apparatus for collection, sealing, and packing of the collected LIS specimen for analysis.
The cognitive trance-based intervention will consist of a two-day workshop in groups of approximately 10 participants, where they will learn how to induce the cognitive trance, with the use of different sound-loops that can induce trance in untrained people in a safe way. After two weeks of home practice, participants will redo a two-day consolidation training. At-home practice is encouraged between sessions.
The invention relates to a traditional Chinese medicine enema. The traditional Chinese medicine enema is prepared from the following raw materials in parts by mass: 30-50 parts of rhubarb, 32-48 parts of safflower, 22-36 parts of prepared rhizoma typhonii, 22-38 parts of Radix Aconiti Lateralis Preparata, 35-60 parts of taraxacum, 38-45 parts of calcined dragon bone, 45-58 parts of calcined oyster shell and 25-35 parts of pasqueflower. In use, the traditional Chinese medicine enema is added into 300ml of warm water of 15-20 DEG C, filled in a disposable enema bag and inserted into the anus for 15-20cm at a speed of 15-30 drops per minute, and retention enema is performed. 30 minutes later, a patient can relieve the bowels. The traditional Chinese medicine enema is used once every other day, and the dosage can be increased to once every day if the creatinine and urea nitrogen levels of the patient are high. The traditional Chinese medicine enema is scientific and reasonable in composition and simple in preparation process, can effectively regulate the creatinine and urea nitrogen indexes, and has a remarkable curative effect for chronic renal failure. The preparation has the advantages of high effective component concentration, convenient use, no pharmaceutical untoward reaction and favorable clinical curative effect. Through traditional Chinese medicine enema, the drug can be directly guided to the focus and quickly take effect; and meanwhile, pain caused by dialysis treatment is avoided.
An intravascular ultrasound (IVUS) analysis system and method is provided which determines luminal and medial-adventitial boundaries of a blood vessel. Ultrasonic data is acquired by a rotating transducer mounted to a tip of a catheter which is inserted into the blood vessel. An intravascular image is reconstructed from the ultrasound data. To determine the luminal boundary of a vessel, a user selects boundary points on the image believed to be locations of the luminal boundary. A boundary contour is generated based on the boundary points. The boundary contour is then optimized by adjusting the boundary points based on a radially determined edge of the luminal boundary performed on the image in polar format. Once the final luminal boundary contour is generated, the process is repeated to determine the medial-adventitial boundary contour. With the contour data, properties of the blood vessel are analyzed including determining the area of the lumen and percent of occlusion caused by plaque.
INTRODUCTION: Obesity affects four in ten US adults. One of the most prevalent health-related social risk factors in the US is housing instability, which is also associated with cardiovascular health outcomes, including obesity. The objective of this research brief is to examine the association between housing instability with obesity status among a representative sample of insured adults across seven integrated health systems.
METHODS: Kaiser Permanente National Social Needs Survey used a multistage stratified sampling framework to administer a cross-sectional survey across seven integrated health systems (administered Jan.-Sept. 2020). Survey data were linked with electronic health records (EHR). Housing instability was categorized into levels of risk: (1) "No Risk"; (2) "Moderate Risk"; and (3) "Severe Risk." Based on established BMI thresholds, obesity, and severe obesity served as the primary outcome variables. In 2023, weighted multivariable logistic regression accounted for the complex sampling design and response probability and controlled for covariates.
RESULTS: The analytic cohort comprised 6,397 adults. Unadjusted weighted prevalence of obesity and severe obesity was 31.1% and 5.3%, respectively; and 15.5% reported housing instability. Adjusted regression models showed that the odds of severe obesity was nearly double among adults exposed to severe housing instability (Adjusted OR=1.93; 95% CI 1.14-3.26). Other BMI categories were not associated with housing instability.
CONCLUSIONS: Among a representative cohort of insured adults, this study suggested increasing levels of housing instability are associated with increasing levels of obesity. Future research should further explore the temporal, longitudinal, and independent association of housing instability with obesity.
A randomized controlled trial with real-world sleep extension in adults with overweight and obesity who habitually obtain short sleep duration will be conducted. Group allocation will be 1:1 and research staff and participants will be blinded until the conclusion of the baseline segment. The sleep extension group will receive counseling and instruction to increase nightly time in bed by 2 hours per night. Participants randomized to control will maintain their habitual sleep habits in their home environment. The intervention segment will last 8 weeks regardless of group assignment. Both groups will have equal contact time with the study team.

Prior to enrollment participants will complete a clinical overnight sleep disorders screening. Baseline consists of an \~1-week ambulatory real-world monitoring segment. Following baseline, participants will be randomized 1:1 to either the sleep extension or control group for 8 weeks at home (intervention segment). Throughout the study, sleep duration will be monitored using an actiwatch wrist-device and a daily electronic sleep log. Following the baseline and intervention segments participants will complete rigorous overnight laboratory visits to assess plasma ceramides (targeted metabolomics assay) and insulin sensitivity (hyperinsulinemic-euglycemic clamp).
Solanum nigrum L. (SN) berry is an edible berry containing abundant polyphenols and bioactive compounds, which possess antioxidant and antiinflammatory properties. However, the effects of SN on alcohol-induced biochemical changes in the enterohepatic axis remain unclear. In the current study, a chronic ethanol-fed mice ALD model was used to test the protective mechanisms of SN berries. Microbiota composition was determined via 16S rRNA sequencing, we found that SN berries extract (SNE) improved intestinal imbalance by reducing the Firmicutes to Bacteroides ratio, restoring the abundance of Akkermansia microbiota, and reducing the abundance of Allobaculum and Shigella. SNE restored the intestinal short-chain fatty acids content. In addition, liver transcriptome data analysis revealed that SNE primarily affected the genes involved in lipid metabolism and inflammatory responses. Furthermore, SNE ameliorated hepatic steatosis in alcohol-fed mice by activating AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), peroxisome proliferator-activated receptor α (PPAR-α). SNE reduced the expression of toll-like receptor 4 (TLR4), myeloid differentiation factor-88 (MyD88) nuclear factor kappa-B (NF-κB), which can indicate that SNE mainly adjusted LPS/TLR4/MyD88/NF-κB pathway to reduce liver inflammation. SNE enhanced hepatic antioxidant capacity by regulating NRF2-related protein expression. SNE alleviates alcoholic liver injury by regulating of gut microbiota, lipid metabolism, inflammation, and oxidative stress. This study may provide a reference for the development and utilization of SN resources.
Participants in this group will receive cognitive remediation training in addition to supported education. Cognitive remediation has two components: computer-based cognitive exercise sessions held on a twice weekly basis for 10 weeks as well as 10 weekly group discussion sessions (approximately 60 minutes in duration).
A longitudinal pre-post design with random assignment of the participants to one of three experimental groups or the control group was used. Quadriceps femoris (QF) function and cortical excitability were assessed on four occasions: prior to the intervention (pre-test), after 3 weeks of training (served for the adjustment of exercise intensity), after 6 weeks of training (post-test), and three weeks after the competition of training intervention (detraining) (Figure 1). Isometric strength training involves activation of QF applying EMS, VOLUNTARY, or the combination of both EMS and VOLUNTARY (COMBINED). The pre-test also served to familiarize participants with the training protocols and to determine the intensity of EMS needed to achieve 60%MVC. Quadriceps femoris (QF) function was assessed by MVC and RFD-SF. Cortical excitability was assessed with transcranial magnetic stimulation applied over the M1 region. Prior to the pretest, body mass and percent of body fat were assessed using a bioelectric impedance method (In Body 720; USA) and body height with a standard stadiometer. After the pretest, the participants were randomly assigned to either one of the experimental groups (EMS, VOLUNTARY, or COMBINED) and the control group (CONTROL). Experimental groups performed unilateral isometric strength training three times per week for 6 weeks. All participants were advised to refrain from all resistance training targeting the legs between pre-test and post-test.
The observed incidence of anti-drug antibodies is highly dependent on the sensitivity and specificity of the assay. Differences in assay methods preclude meaningful comparisons of the incidence of anti-drug antibodies in the trials described below with the incidence of anti-drug antibodies in other trials. 

During the 40- to 104-week treatment periods with ADA sampling conducted up to 44 to 108 weeks in seven clinical trials in adults with type 2 diabetes mellitus [see Clinical Studies (14)], 51% (2,570/5,025) of MOUNJARO-treated patients developed anti-tirzepatide antibodies. In these trials, anti-tirzepatide antibody formation in 34% and 14% of MOUNJARO-treated patients showed cross-reactivity to native GIP or native GLP-1, respectively. 

Of the 2,570 MOUNJARO-treated patients who developed anti-tirzepatide antibodies during the treatment periods in these seven trials, 2% and 2% developed neutralizing antibodies against tirzepatide activity on the GIP or GLP-1 receptors, respectively, and 0.9% and 0.4% developed neutralizing antibodies against native GIP or GLP-1, respectively. 

There was no identified clinically significant effect of anti-tirzepatide antibodies on pharmacokinetics or effectiveness of MOUNJARO. More MOUNJARO-treated patients who developed anti-tirzepatide antibodies experienced hypersensitivity reactions or injection site reactions than those who did not develop these antibodies [see Adverse Reactions (6.1)].
Physiotherapy and physical activity interventions can reduce fatigue, improve balance, walking, HRQoL, and may improve neuromuscular and physical functioning in people with MS. However, these interventions lack coordination between health care levels and sectors and rarely address vital employment adaptations. Optimizing function and physical activity, when disability is low and neuroplasticity is optimal, can be valuable for maintaining work as levels of fatigue, mobility related symptoms and cognitive disturbances are associated with current employment.

People with an MS-diagnosis who reside in the North of Norway will be identified from patient lists from the neurological out-patient clinics in the participating hospitals. Upon the provision of written informed consent, all participants will undergo baseline testing prior to randomization into either the intervention or the control group. The intervention group will receive a physiotherapy assessment at the hospitals focusing on opportunities for change. Following this assessment they will participate in group training with a municipality physiotherapist twice weekly for six weeks followed by independent training for six weeks. In addition, both participants and their employers will get access to information films on opportunities for work adaptations and the importance of physical activity. Structured meetings with a specially trained employment consultant, the participant and their employer will be held to discuss possible work adaptations. Goals will be set and formally evaluated. Retests will be carried out at week 9, 16 and 52. Registry data on employment will be obtained from the Norwegian labour and welfare administration as a part of a cost-benefit analysis of the intervention.
A medicine for treating giddiness due to wind phlegm and blood stasis is prepared from rhizoma Gastrodiae, rhizoma Pinelliae Preparata, pericarpium Citri Tangerinae, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, fructus Vitics Simplicifoliae, radix Puerariae, and radix scrophulariae. The gastrodia elata enters liver meridian and is a key medicine for treating wind; rhizoma Pinelliae Preparata enters spleen, stomach and lung channels, and has the functions of eliminating dampness and phlegm, lowering adverse qi and relieving vomiting, and is mainly used for treating vertigo caused by phlegm-dampness; the rhizoma ligustici wallichii is mainly used for entering liver channels, ascending head and eyes, promoting qi and activating blood circulation to dissipate blood stasis, and the rhizoma ligustici wallichii, the liver channels, the head and eyes and the blood circulation are used as monarch drugs for calming endogenous wind and reducing phlegm, and activating blood and stopping dizziness. The tangerine peel, the kudzuvine root and the red sage root are ministerial drugs, the tangerine peel can invigorate the spleen and reduce phlegm, the kudzuvine root can promote blood circulation and remove meridian obstruction, particularly the meridian passage of bladder meridian, the red sage root can promote blood circulation, nourish blood and tranquilize mind, and the ligusticum wallichii can promote blood circulation and remove meridian obstruction at the top of the mountain. The three drugs can enhance the effect of the ministerial drugs in promoting blood circulation and reducing phlegm. Xuan Shen is sweet and cold in nature and can nourish yin, and is an adjuvant drug for dryness in some prescriptions. Vitex rotundifolia is used as a guiding drug for directing various herbs upward to the disease origin, dispelling wind-heat and clearing head and eyes. The medicines are combined to eliminate dampness and phlegm, calm the liver and stop endogenous wind, activate blood and dredge collaterals and stop dizziness.
1506016 Encapsulated digoxin solution WELLCOME FOUNDATION Ltd 21 Feb 1975 [22 Feb 1974 19 March 1974] 7327/75 Heading A5B An orally ingestible digoxin preparation of improved properties comprises a capsule soluble in the stomach or duodenum contaming a solution of digoxin, the amount of digoxin in the capsule being less than that in a conventional tablet but nonetheless providing the same physiological effect as the conventional tablet. The capsule may contain 0.05-0.4mg. digoxin. Solvents specified include ethanol, isopropanol, propylene glycol, glycerol and polyethylene glycol of molecular weight 190-1000. The solvent may include up to 60 % water. The capsule may be a soft gelatin capsule including a plasticizer, preservative, colouring and/or opacifier.
INTRODUCTION AND HYPOTHESIS: Self-efficacy for pelvic floor exercises, i.e. confidence in achieving pelvic floor contractions, may predict adherence to treatment. However, there is a paucity of literature investigating the clinical relevance of this outcome. The aim was to determine the relationship between self-efficacy for pelvic floor exercise and symptom severity, pelvic floor distress and impact on quality of life, as well as sociodemographic characteristics and pelvic floor muscle strength in women with stress urinary incontinence (SUI).
METHODS: A cross-sectional study was conducted in women with SUI. The Spanish version of the Broome Pelvic Muscle Self-Efficacy Scale was used to assess self-efficacy for pelvic floor exercise. The dependent variables were: urinary incontinence symptoms using the International Consultation on Incontinence Questionnaire, short form (ICIQ-SF), pelvic floor distress symptoms using the Urogenital Distress Inventory-6, impact on quality of life using the Incontinence Impact Questionnaire (IIQ-7), leakage using the 1-h pad test, number of SUI episodes per week and pelvic floor muscle strength.
RESULTS: A total of 56 women with a median age of 44.5 years were included. Self-efficacy for pelvic floor exercise correlated negatively and moderately with the ICIQ-SF (r = -0.529; p < 0.001), IIQ-7 (r = -0.442; p = 0.001), 1-h pad test (rs = -0.467; p < 0.001); and number of SUI episodes/week (rs = -0.489; p < 0.001). Correlation with the other outcomes was weak or non-existent. Linear regression with forward selection showed that the ICIQ-SF was the variable most related to self-efficacy (β: -3.01, 95% CI: -4.03 to -1.69).
CONCLUSIONS: These findings highlight the importance of assessing self-efficacy for pelvic floor exercise in the treatment of women with SUI. Future prospective studies are needed to confirm these findings.