anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain an agent capable of suppressing the formation of tyrosinase beforehand in place of inhibiting the action and activity of the enzyme, and useful in the fields of pharmaceuticals, cosmetics, etc., by using acetic acids, lactic acids and pyruvic acids as active components. CONSTITUTION:The objective agent can be produced by using an active component comprising one or more compounds selected from acetic acids, lactic acids and pyruvic acids which are tyrosinase-formation inhibiting substances having high safety and stability and forming the active component in the form of a drug by conventional method. The concentration of the tyrosinase-formation inhibiting substance is usually 0.002-10M and the pH of the agent is adjusted to 2.5-9.0. The daily dose of the tyrosinase-formation inhibiting substance is 0.01-1,000g for adult. It can be formed in the form of a drug such as injection, medicine for internal use, external medicine or bathing agent or a cosmetic such as milky lotion, pack or cream. The tyrosinase-formation inhibiting agent has strong effect to suppress the formation of melanin and gives fair skin.
The invention relates to a medicament for treating rheumatism, in particular to a medicament for treating rheumatism, which is prepared from animal and plant Chinese herbal medicines as raw materials, and a preparation method thereof. The invention solves the problems that the medicament in the prior art has a poor curative effect and only cures the symptoms but not the root causes. The medicament is used for treating rheumatism, has a high effect taking speed and is suitable for patients suffering from chronic rheumatism to take for a long time. The medicament is prepared from the following raw materials in parts by weight: 30-50 parts of gentiana macrophylla, 30-50 parts of dipsacus asper, 30-50 parts of cibotium barometz, 30-50 parts of homalomena rhizoma, 20-40 parts of chuanxiong rhizome, 5-15 parts of radix aconiti agrestis, 7-18 parts of radix aconiti, 30-50 parts of garter snake, 30-50 parts of berba aristolochiae mollissimae and 30-50 parts of angelica. The medicament is a water-floating pill which is formed by drying in the shade or directly putting medicinal powder into a capsule, or honey is added so as to prepare a honeyed pill. The medicament provided by the invention, which is prepared from pure natural animal and plant Chinese herbal medicines, has mild medicinal properties and does not have toxic or side effects and adverse reactions, thereby being suitable for patients suffering from rheumatism to take for a long time.
Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains under-explored. Here, we used CRISPR-based screening in human iPSC-derived astrocytes to identify mTOR activation a driver of cytokine-induced endolysosomal system remodeling, manifesting as alkalinization of endolysosomal compartments, decreased autophagic flux, and increased exocytosis of certain endolysosomal cargos. Through endolysosomal proteomics, we identified and focused on one such cargo-IL-32, a disease-associated pro-inflammatory cytokine not present in rodents, whose secretion mechanism is not well understood. We found that IL-32 was partially secreted in extracellular vesicles likely to be exosomes. Furthermore, we found that IL-32 was involved in the polarization of inflammatory reactive astrocyte states and was upregulated in astrocytes in multiple sclerosis lesions. We believe that our results advance our understanding of cell biological pathways underlying inflammatory reactive astrocyte phenotypes and identify potential therapeutic targets.
PALFORZIA is an oral immunotherapy indicated for the mitigation of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut. PALFORZIA is approved for use in patients with a confirmed diagnosis of peanut allergy. Initial Dose Escalation may be administered to patients aged 4 through 17 years. Up-Dosing and Maintenance may be continued in patients 4 years of age and older [see Dosage and Administration (2.4)] . 

PALFORZIA is to be used in conjunction with a peanut-avoidant diet.

Limitation of Use: Not indicated for the emergency treatment of allergic reactions, including anaphylaxis.
A stem cell is capable of forming various tissue under definite signals received from the body. Stem cell research in animals has been an ongoing program in the west with fruitful results. Current challenges with the use of stem cells in clinical practice will be solve the many unanswered queries. To study the potential therapeutic effects of local Mesenchymal Stem cell injection in children presenting with fecal incontinence (FI) after posterior sagittal ano-rectoplasty (PSARP) operation for high imperforate anus. Children whom suffering from FI after PSARP for high imperforate anus will included in this study. Autologous MSC from the upper posterior iliac crest bone marrow sample will be extracted from patients under general anesthesia, in a suitable clean operation room. Will be Cultured and injected into the external anal sphincter defect using direct pena stimulator or ultra sound guidance. Then followed up for 180 days post injection, to assess the ability of mesenchymal stem cells to induce myogenesis of the anal Sphincter of patients with FI after PSARP.
Cosmetic agents and methods for temporarily shaping keratin-containing fibers using the cosmetic agents are provided herein. In one embodiment, the cosmetic agent includes a cosmetic carrier. The cosmetic agent further includes at least one chitosan or derivative thereof. The cosmetic agent further includes at least one hydrophobic pyrogenic silicic acid. The cosmetic agent also includes at least one non-ionic, anionic, or amphoteric film-forming polymer. In another embodiment, the method includes the step of using the cosmetic agent for temporarily shaping keratin-containing fibers.
A single oral dose of fezolinetant will be administered with water under fasting conditions on day 1 (low dose), day 4 (medium dose) and day 7 (high dose). From day 10 to day 15, the medium dose of fezolinetant will be administered with water after breakfast once daily. On day 16, the medium dose of fezolinetant will be administered with water under fasting conditions.
BACKGROUND: To the best of our knowledge, no study has investigated the potential joint effect of large for gestational age (LGA) and assisted reproductive technology (ART) on the long-term health of children.
METHODS: This was a prospective cohort study that recruited children whose parents had received ART treatment in the Center for Reproductive Medicine, Shandong Provincial Hospital, affiliated to Shandong University, between January 2006 and December 2017. Linear mixed model was used to compare the main outcomes. The mediation model was used to evaluate the intermediary effect of body mass index (BMI).
RESULTS: 4138 (29.5%) children born LGA and 9910 (70.5%) children born appropriate for gestational age (AGA) were included in the present study. The offspring ranged from 0.4 to 9.9 years. LGAs conceived through ART were shown to have higher BMI, blood pressure, fasting blood glucose, fasting insulin, and homeostatic model assessment of insulin resistance values, even after controlling for all covariates. The odds of overweight and insulin resistance are also higher in LGA subjects. After adjusting for all covariates, LGAs conceived through ART had BMI and BMI z-scores that were 0.48 kg/m2 and 0.34 units greater than those of AGAs, respectively. The effect of LGA on BMI was identified as early as infancy and remained consistently significant throughout pre-puberty.
CONCLUSIONS: Compared to AGA, LGA children conceived from ART were associated with increased cardiovascular-metabolic events, which appeared as early as infancy and with no recovery by pre-puberty.
NEW MATERIAL:A compound shown by formula I (1 is 0-3; m is 0 or 1; R<1> is OH, alkoxy or amino; R<2> is halogen, trihalomethyl, alkyl, alkoxy or OH; A is heterocyclic). EXAMPLE:Ethyl 2-(1-imidazolyl)methyl-1,4-benzodioxane-6-carboxylate. USE:An inhibitor of blood platelet aggregation, anti-inflammatory drug and analgesic. PREPARATION:A compound shown by formula II (R is methyl, ethyl, n-propyl, etc.) is treated with methanesulfonyl chloride in pyridine to give a mesylate shown by formula III. Further this compound is reacted with a compound shown by formula V in the presence of a base in a solvent such as DMF to give a compound shown by formula VI and then this compound is hydrolyzed in the presence of an inorganic base to give a compound shown by formula I.
A composition containing black seed ingredients in water or liquid, solution or compound grows and regrows hair on body. With application of this water or liquid, solution or compound caring inherent ingredients of black seeds on body, existing or thinning hair become thick, healthy and long. Black seed possess inherent natural ingredients to grow and regrow hair. Black seed can be processed with any liquid in multiple ways to help grow and regrow hair. When black seed's inherent ingredient is fed to hair, follicles or hair roots it provides the nutritional boost that they need to grow and regrow to their natural full growth potential. Bald spots on area of body where hair existed once, starts re-growing hair once again. In addition, Black seed also possess inherent natural ingredients that can cure cancer, kill AIDS, bird flu viruses or other viruses in body. Black seed can be processed in multiple ways to deal with cancer cells. It gives nutritional boost needed to improve immune system of body. The crude oil, thymoquinone (TQ) and other oils extracted from black seeds are effective against many diseases like cancer, cardiovascular, diabetes, asthma, kidney disease, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza, eczema etc. It is also effective against cancer in blood system, lung, kidney, liver, prostate, breast, cervix, skin and other organs safely. TQ has antioxidant helps body defences, influence apoptosis and handles P13K-Akt pathway of cells.
PURPOSE:To provide a diagnostic composed of an antinuclear antibody labeled with radioisotope and useful for the imaging diagnosis of cancer. CONSTITUTION:A diagnostic composed of an antinuclear antibody labeled with a radioisotope (e.g. <99m>Tc, <123>I, <131>I, etc.). A remarkable progress in the imaging diagnosis with radioisotope has been achieved by the use of a monoclonal antibody, and the imaging diagnosis of cancer is being attempted by using a cancer- specific monoclonal antibody. However, it is necessary to prepare various kinds of monoclonal antibodies according to the kind of cancer, and there occurs the problems of specificity taking account of the heterogeneity of cancer antigen, antigen modulation, masking of cancer antigen, etc., and accordingly, the accurate diagnosis is difficult. Imaging diagnosis of cancer can be carried out by labeling an antinuclear antibody with a radioisotope since an antinuclear antibody is not accumulated in a normal tissue but accumulated in a necrotic tissue of cancer. The diagnostic is administered parenterally in a dose of about <=60mCi.
Participants will receive the following treatment regimens: LDRT concurrent cisplatin/carboplatin + etoposide + atezolizumab. Induction treatment will be administered on a 21-day cycle for four cycles. Concurrent radiation therapy will be conducted from Day 1 - Day 5 in the first cycle. Following the induction phase, participants will continue maintenance therapy with atezolizumab. Participants will be treated until loss of clinical benefit, or unaccepted toxicity, or withdrawal of consent, or death (whichever occurs first).
Background. In cases with pleural effusion, tissue samples can be obtained through Abrams' needle pleural biopsy, thoracoscopy, or cutting-needle pleural biopsy under the guidance of computerized tomography or ultrasonography for histopathological analysis. This study aims to compare the diagnostic efficiency and reliability of Abrams' needle pleural biopsy under computerized tomography guidance with that of cutting-needle pleural biopsy under ultrasonography guidance in patients with pleural effusion.

Methods. Patients with exudative pleural effusion, who could not be diagnosed by cytological analysis, will be included in the study. All patients were randomized following the thoracic computerized tomography with contrast enhancement. Patients either underwent Abrams' needle pleural biopsy under computerized tomography guidance or the cutting-needle pleural biopsy under ultrasonography. The two groups will be compared in terms of diagnostic efficiency and in terms of complications associated with the methods used.
BACKGROUND: Ulcerative colitis (UC) is a lifelong inflammatory disease affecting the rectum and colon with numerous treatment options that require an individualized treatment plan. Histone modifications regulate chromosome structure and gene expression, resulting in effects on inflammatory and immune responses. However, the relationship between histone modification-related genes and UC remains unclear.
METHODS: Transcriptomic data from GSE59071 and GSE66407 were obtained from the Gene Expression Omnibus (GEO), encompassing colonic biopsy expression profiles of UC patients in inflamed and non-inflamed status. Differentially expressed gene (DEG) analyses, functional enrichment analyses, weighted gene co-expression network analysis (WGCNA), and random forest were performed to identify histone modification-related core genes associated with UC inflammation. Features were screened through the least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE), establishing a molecular inflammatory predictive model using logistic regression. The model was validated in the GSE107499 dataset, and the performance of the features was assessed using receiver operating characteristic (ROC) and calibration curves. Immunohistochemistry (IHC) staining of colonic biopsy tissues from UC patients treated with infliximab was used to further confirm the clinical application value. Univariate logistic regression on GSE14580 highlighted features linked to infliximab response.
RESULTS: A total of 253 histone modification-related DEGs were identified between inflammatory and non-inflammatory patients with UC. Seven key genes (IL-1β, MSL3, HDAC7, IRF4, CAMK2D, AUTS2, and PADI2) were selected using WGCNA and random forest. Through univariate logistic regression, three core genes (CAMK2D, AUTS2, and IL-1β) were further incorporated to construct the molecular inflammatory predictive model. The area under the curve (AUC) of the model was 0.943 in the independent validation dataset. A significant association between CAMK2D protein expression and infliximab response was observed, which was validated in another independent verification set of GSE14580 from the GEO database.
CONCLUSION: The molecular inflammatory predictive model based on CAMK2D, AUTS2, and IL-1β could reliably distinguish the mucosal inflammatory status of UC patients. We further revealed that CAMK2D was a predictive marker of infliximab response. These findings are expected to provide a new evidence base for personalized treatment and management strategies for UC patients.
Epilepsy in children is a major public health issue. It is the first neurological disease of the child. The specific incidence of epilepsy rates were highest during the first year of life, between 75,105 and 250,105 hab.an hab. year and remain high in the age group between 0 and 10 years. Epilepsies predictions are varied. They can be spontaneously benign, drug-, chemically dependent or drug-resistant. These, refractory epilepsies, represent 20% of epilepsy as a child and adolescent than adult is about 1200 children and 1200 adults Picardy. The validation of non-invasive investigative tools is becoming a necessity in the management of drug-resistant epilepsies especially when a surgical decision is envisaged. The aftermath (motor, cognitive, sensory) appear to rule early; but they are sometimes limited to learning deficits detected later in the school curriculum. The investigators know that defects in neuronal electrical activity (eg critical discharges) induce a metabolic response and conversely metabolic disturbances can cause abnormal electrical activity. It is therefore important to have tools to better characterize the interactions between these two mechanisms to better understand brain function in the brain during development and during pathological situations. The investigators lack quantitative criteria regarding the impact of crises on the metabolic activity and thus predictive criteria consequences of crises on brain function. The deleterious hazard must be considered at all ages in both structures to causing seizures than in those where the crisis spread. The functional characterization, electrical, metabolic and anatomic pathology of these networks is necessary and contributes to a better understanding of physiological and pathological brain function, and helps to define the most appropriate treatment strategy.

About childhood epilepsy, analysis of the EEG allows in 75% of cases to find predictive patterns characteristic of becoming. However in 25% of cases, we lack predictive objective criteria. This highlights the importance of developing analysis tools for more accurate and efficient brain function and to improve the management and evaluation of the prognosis of these children.
The invention provides a foot bath health-care traditional Chinese medicine benefiting Qi and activating blood and relates to the field of traditional Chinese medicines. The traditional Chinese medicine is prepared from 10-15 g of folium artemisiae argyi, 8-10 g of cassia twigs, 8-10 g of ligusticum chuanxiong hort, 10-15 g of notopterygium roots, 10-15 g of Chinese parsnip roots, 15-20 g of fresh ginger, 8-10 g of Chinese prickly ash, 10-15 g of safflower carthamus, 10-15 g of motherworts and 8-10 g of ginseng. By means of many years of practiced medicine experience analysis of an inventor, qi deficiency of a human body is mostly caused by natural endowment deficiency or postnatal malnutrition or loss caused by excessive fatigue, or aeipathia or viscera function hypofunction of lungs, spleens, kidneys and the like, or biochemistry insufficiency of qi and the like. Thus, conditioning is important, medicines benefiting Qi and activating blood should be used, the traditional Chinese medicine is prepared, and the blood and the qi of a human body can be full from inside to outside. According to the formula of the traditional Chinese medicine, a patient can fill a prescription by himself/herself to prepare a foot bath medicine bag through a foot bath method. The effects of benefiting Qi and activating blood and making a user full of energy can be achieved when the traditional Chinese medicine is taken for a long time.
INTRODUCTION: Speech and language therapists (SLTs) worldwide report challenges with providing recommended, evidence-based intervention intensity for children with speech sound disorder (SSD). Challenges such as service constraints and/or family contexts impact on access to optimal therapy intensity. Existing research indicates that empowering and training parents to deliver intervention at home, alongside SLT support, offers one possible solution to increasing the intensity of intervention children with SSD receive. Digital health could increase accessibility to intensive home practice and help sustain engagement with therapy activities. Further exploration is needed around what makes parent-implemented interventions for children with SSD effective, for who and in which situations. This paper outlines the protocol for a realist review which aims to explore the active ingredients and contextual factors of effective digital parent-led interventions.
METHODS AND ANALYSIS: A realist review will explore the research question, following six stages. The scope of the review will be determined, and initial programme theories will be developed about what works in digital parent-implemented interventions for SSD, for whom, how, why and in what circumstances. Relevant secondary data, identified through a formal search strategy, will be selected, appraised, analysed and synthesised using realist principles to test and further refine the initial programme theories. This process will develop refined underpinning explanatory theories which capture the interaction between contexts, mechanisms and outcomes of the intervention. An expert steering group will provide insight to inform explanatory theories, searches, and dissemination.
ETHICS AND DISSEMINATION: Ethical approval is not required for this review. The refined programme theories from the review will inform the next stages of a wider study. A subsequent realist evaluation will test and further refine theories with key stakeholders. Following this, the underpinning programme theory will be used to coproduce a digital tool, to support parents to deliver home intervention alongside SLT support.
The experimental group will be provided a pressure injury prediction of the patient and personalized care information of pressure injury by a smart care platform. The participants (primary caregivers) will fill out the questionnaires online at admission (baseline-T0) and before the patient is discharged(T1). The questionnaires will collect the following data, including demographic information(only T0), knowledge, self-efficacy, anxiety, depression of wound care(T0\&T1), and satisfaction of the smart care platform(only T1). The time to fill out the questionnaires will be about 10 minutes.
The multidimensional etiology of pain may explain the beneficial effects of regular physical activity, as evidenced by increased pain tolerance. Physically active people find it easier to exert themselves, which enables them to increase their physical activity, which in turn leads to a reduction in pain. However, no study investigated the physical activity and exercise tests as modulators of pain sensitivity in pregnant women. Therefore, this study aimed to investigate the changes in pain perception in pregnant women during pregnancy, with a particular interest in the effects of maximal progressive exercise test (CPET) and self-performed physical activity (PA). Thirty-one women with an uncomplicated singleton pregnancy (aged 23-41 years; M = 31.29, SD = 4.18) were invited to participate in pain sensitivity measurements before and after CPET twice during pregnancy (with an 8-week break). We found that pregnant women had a significantly lower pain threshold after a maximal exercise test than before, regardless of whether the test was performed in the second or third trimester of pregnancy. This effect was most pronounced in women with low levels of physical activity. Second, women with high physical activity had higher pain tolerance than women with moderate and low physical activity. In addition, physical activity levels predicted changes in pain tolerance over the course of pregnancy, with negative changes in women with low physical activity and positive changes in women with moderate physical activity. Finally, these associations were not reflected in differences in the subjective pain experience.