anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
All Patients taking doxycycline should be advised:

\- to avoid excessive sunlight or artificial ultraviolet light while receiving doxycycline and to discontinue therapy if phototoxicity (e.g., skin eruptions, etc.) occurs. Sunscreen or sunblock should be considered. (See WARNINGS.)

\- to drink fluids liberally along with doxycycline to reduce the risk of esophageal irritation and ulceration. (See ADVERSE REACTIONS.)

\- that the absorption of tetracyclines is reduced when taken with foods, especially those which contain calcium. However, the absorption of doxycycline is not markedly influenced by simultaneous ingestion of food or milk. (See Drug Interactions.)

\- that the absorption of tetracyclines is reduced when taking bismuth subsalicylate. (See Drug Interactions.)

\- not to use outdated or poorly stored doxycycline.

\- that the use of doxycycline might increase the incidence of vaginal candidiasis.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

Patients should be counseled that antibacterial drugs including doxycycline should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When doxycycline tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by doxycycline or other antibacterial drugs in the future.
Oral contraceptives containing 0.030 mg ethinyl estradiol and 3mg drospirenone will be administered. One tablet a day for the duration of the trial.
This comparison study is performed to show equivalence of CEUS with CECT or CEMR to diagnose noninvasively focal liver masses. This is a multi-center prospective cohort study of 250 subjects, which will be performed at four institutions in Canada. Subjects with a focal liver mass, measuring at least 2.5 centimeters in maximal diameter, will undergo a conventional baseline sonogram followed by a contrast enhanced ultrasound (CEUS). CEUS will be performed on standard ultrasound scanners with contrast specific imaging capability. The contrast agent used is Definity (Lantheus Medical Imaging, Billerica,MA) All subjects will have either a dedicated hepatic contrast enhanced CT or MR scan within 60 days of the CEUS as per the standard of care in the institution. Anonymized image files from all imaging will be shown independently to two readers, blinded to all clinical and demographic data, who will predict malignancy and diagnosis.
Bupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone. It has the following structural formula:

Epinephrine is (-)-3,4-Dihydroxy-α-[(methylamino)methyl] benzyl alcohol. It has the following structural formula:

MARCAINE is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1:200,000 for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks. Solutions of MARCAINE may be autoclaved if they do not contain epinephrine. Solutions are clear and colorless.

Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. It is a homologue of mepivacaine and is chemically related to lidocaine. All three of these anesthetics contain an amide linkage between the aromatic nucleus and the amino, or piperidine group. They differ in this respect from the procaine-type local anesthetics, which have an ester linkage.

MARCAINE—Sterile isotonic solutions containing sodium chloride. In multiple-dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 4 and 6.5 with sodium hydroxide or hydrochloric acid.

MARCAINE with epinephrine 1:200,000 (as bitartrate)—Sterile isotonic solutions containing sodium chloride. Each mL contains bupivacaine hydrochloride and 0.0091 mg epinephrine bitartrate, with 0.5 mg sodium metabisulfite, 0.001 mL monothioglycerol, and 2 mg ascorbic acid as antioxidants, 0.0017 mL 60% sodium lactate buffer, and 0.1 mg edetate calcium disodium as stabilizer. In multiple-dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 3.4 and 4.5 with sodium hydroxide or hydrochloric acid. The specific gravity of MARCAINE 0.5% with epinephrine 1:200,000 (as bitartrate) at 25°C is 1.008 and at 37°C is 1.008.
The basic service package offers a mixture of recreational and non-formal education activities over a twelve-week period. Each session lasts around 1.5 - 3 hours. Structured activities offered include basic literacy and numeracy lessons, life skills exercises, health and hygiene sessions, and traditional song and dance. Many activities are centered around various forms of play that enable expression and age-appropriate skill development. Unstructured free play and playground time is allocated throughout the daily session.
The invention provides a method of preparing a dog food composition formulated for a small dog having a certain body conformation type, the method comprising categorizing the small dog expected to consume the food composition. Preferably the small dog is classified as a robust or athletic body conformation type. The method further comprises formulating a dog food composition to comprise feeding ingredients and in amounts based on the classification of the small dog. The protein and fat content of the food composition can be adjusted according to the robust or athletic category of a particular dog or type of dog. The classification uses a modified body mass index, i.e. body weight/[ (height-height of sternum to floor) × body length ]. In some embodiments, the classifying can use skin fold measurements.
BFR cuff will not be deflated at the end of each of the 4 BFR exercises. Cuff remains inflated start exercise 1 thru completion exercise 4.
Between 2% and 15% of pregnant women unknowingly experience asymptomatic bacteriuria (ASB), defined as ≥105 CFU per milliliter of urine in the absence of symptoms. ASB increases the risk of adverse pregnancy outcomes including pyelonephritis, preterm labor, and low-birth weight infants. While pregnant women in the United States are routinely screened for ASB, those in developing countries with limited resources and funding lack an accurate mechanism for ASB screening. Aquagenx water quality test kits detect Escherichia coli, the most common causative agent of ASB, and total coliform bacteria in drinking water via colorimetric and fluorescent indicators. We found that the Aquagenx system is compatible with human urine and then proceeded to develop an ASB screening protocol using disposable inoculating loops. Our protocol diagnosed artificial ASB- samples (104 CFU/mL E. coli) with a false positive (FP) rate of 33% (n = 18) and ASB+ (105 CFU/mL E. coli) with a false negative (FN) rate of 5.6% (n = 18). Clinical sample testing with our protocol revealed a FP rate of 0% in ASB- samples (n = 28) and a FN rate of 0% in ASB+ samples caused by coliforms (n = 13). Aquagenx did not detect ASB in nine clinical samples with non-coliform etiological agents due to the limitations of the technology. However, with very high accuracy for detection of E. coli and other causative agents that collectively account for 90.1% of ASB cases, these kits could be used as a diagnostic ASB screening tool in developing countries in which there is currently no alternative to urine culture.IMPORTANCEAsymptomatic bacteriuria (ASB) affects 2%-15% of pregnant women and can result in adverse maternal and fetal outcomes if left undetected and untreated. In the United States and other developed nations, pregnant women are regularly screened for ASB via urine culture. However, in low-resource countries where bacterial culture is not available, dipstick testing is used. Although accurate in cases of symptomatic bacteriuria, dipstick detection is ineffective for detecting ASB. Here, we made use of an existing water quality field test for ASB urine screening, which would be readily deployable in low-resource settings. We optimized a dilution protocol for sampling patient urine within the detection limits of the Aquagenx kit technology. Overall, we were able to detect ASB samples with Gram-negative pathogens that collectively account for 90% of all ASB cases. Utilization of this repurposed technology for proactive medical screening may help prevent adverse pregnancy and birth outcomes due to ASB.
Dental filler mixt. contains (a) a metallic component, present as a coherent structure having open cavities, and (b) a non-metallic liq. or plastic component solidifying at 15-40 deg.C, pref. a standard dental resin, dental cement or adhesive. The metallic component can be a porous body, prepd. by sintering metal powders or by dissolving less noble constituents from their alloys. Wire coils or netting, produced from fine wires having dia. below 0.1 mm, can also be used. The metal materials are esp. Au, Ag, Pt, their alloys, or corrosion-resistant and dental tissue-compatible Fe-, Ni, Co, Al and Ti alloys. Use of a coherent metal structure, in place of a powdered metal component, improves mechanical properties, e.g. compressive- and flexural strength, creep and edge tensile strength.
Marketed product applied following manufacturer's recommendation. The product is 15% zinc oxide with petrolatum.
The work will evaluate the metabolic costs for daily activities across the lifespan and evaluate the influence of having functional impairments. The project will simultaneously conduct a cross-sectional and a case-control study. The primary aim will investigate cross-sectional association between older age and the energy expenditure of daily activities by recruiting approximately 25 adults in each of 7 age groups (20-30,30-40,40-50,50-60,60-70,70-80,80+) for a total of 180 individuals. A secondary aim will investigate the effect of functional impairments on the energy expenditure of daily activities by conducting a case-control study. An additional 25 older adults with functional impairment will be recruited in each age decade (60-70, 70-80, and 80+ years old) to accomplish this aim. Additional outcomes will evaluate rating of perceived exertion differences in daily activities. A tertiary aim will investigate using accelerometers to predict the metabolic costs of daily activities.
The heat shock response is a critical component of the inflammatory cascade that prevents misfolding of new proteins and regulates immune responses. Activation of clusters of differentiation (CD)4+ T cells causes an upregulation of heat shock transcription factor, heat shock factor 1 (HSF1). We hypothesized that HSF1 promotes a pro-regulatory phenotype during inflammation. To validate this hypothesis, we interrogated cell-specific HSF1 knockout mice and HSF1 transgenic mice using in vitro and in vivo techniques. We determined that while HSF1 expression was induced by anti-CD3 stimulation alone, the combination of anti-CD3 and transforming growth factor β, a vital cytokine for regulatory T cell (Treg) development, resulted in increased activating phosphorylation of HSF1, leading to increased nuclear translocation and binding to heat shock response elements. Using chromatin immunoprecipitation (ChIP), we demonstrate the direct binding of HSF1 to foxp3 in isolated murine CD4+ T cells, which in turn coincided with induction of FoxP3 expression. We defined that conditional knockout of HSF1 decreased development and function of Tregs and overexpression of HSF1 led to increased expression of FoxP3 along with enhanced Treg suppressive function. Adoptive transfer of CD45RBHigh CD4 colitogenic T cells along with HSF1 transgenic CD25+ Tregs prevented intestinal inflammation when wild-type Tregs did not. Finally, overexpression of HSF1 provided enhanced barrier function and protection from murine ileitis. This study demonstrates that HSF1 promotes Treg development and function and may represent both a crucial step in the development of induced regulatory T cells and an exciting target for the treatment of inflammatory diseases with a regulatory T-cell component. SIGNIFICANCE STATEMENT: The heat shock response (HSR) is a canonical stress response triggered by a multitude of stressors, including inflammation. Evidence supports the role of the HSR in regulating inflammation, yet there is a paucity of data on its influence in T cells specifically. Gut homeostasis reflects a balance between regulatory clusters of differentiation (CD)4+ T cells and pro-inflammatory T-helper (Th)17 cells. We show that upon activation within T cells, heat shock factor 1 (HSF1) translocates to the nucleus, and stimulates Treg-specific gene expression. HSF1 deficiency hinders Treg development and function and conversely, HSF1 overexpression enhances Treg development and function. While this work, focuses on HSF1 as a novel therapeutic target for intestinal inflammation, the findings have significance for a broad range of inflammatory conditions.
JC virus infection resulting in PML and death can occur in rituximab product-treated patients with hematologic malignancies or with autoimmune diseases. The majority of patients with hematologic malignancies diagnosed with PML received rituximab in combination with chemotherapy or as part of a hematopoietic stem cell transplant. The patients with autoimmune diseases had prior or concurrent immunosuppressive therapy. Most cases of PML were diagnosed within 12 months of their last infusion of rituximab.

Consider the diagnosis of PML in any patient presenting with new-onset neurologic manifestations. Evaluation of PML includes, but is not limited to, consultation with a neurologist, brain MRI, and lumbar puncture.

Discontinue RIABNI and consider discontinuation or reduction of any concomitant chemotherapy or immunosuppressive therapy in patients who develop PML.
Patients in this arm receive Durvalumab alone. Durvalumab is administered intravenously (IV) at a dose of 1500 mg every 4 weeks. This arm is designed to evaluate the efficacy and safety of Durvalumab monotherapy in patients with colorectal or endometrial cancer.
The present invention relates to drug field, in particular to a kind of little Hua Asystasia gangetica (L) Anders.(A. Coromandelihas Nees)s prepare prevent and/or the medicine for the treatment of nerve degenerative diseases in application and medicine.Application of the little Hua Asystasia gangetica (L) Anders.(A. Coromandelihas Nees)s in the medicine for preparing prevention and/or treatment nerve degenerative diseases.Inventor has found that little Hua Asystasia gangetica (L) Anders.(A. Coromandelihas Nees)s and its extract can protect neuron to make its injury-free, so as to prevent or postpone nerve cell death.Confirm that medicine that raw material contains little Hua Asystasia gangetica (L) Anders.(A. Coromandelihas Nees)s can make the nerve cells of HT 22 keep fit form and propagation；Illustrate that little Hua Asystasia gangetica (L) Anders.(A. Coromandelihas Nees)s can be used for preparing treatment or prevention axoneuron gradually occurs to be denatured, in the medicine of apoptosis.
PURPOSE:To simplify various types of processing and also to improve the file processing efficiency by controlling en bloc the superscription data of each patient and the data on compounding of medicines at plural medical institutions of the same patient. CONSTITUTION:A patient superscription file 7 is retrieved and the superscription data is displayed after the name of a patient is supplied. Then an identification code A corresponding to a medical instruction T1 is supplied for retrieval of a master file for medical institutions, and the name of the medical institution is displayed. When the data on compounding of medicines is supplied, the data on compounding of medicines of medical institutions following the institution T1 are shifted downward with reference to the contents of a pointer 12a corresponding to the code A and the following pointer 12b. Then data D11 and D12 on compounding of medicines of that day are written after the final data D4 of the institution T1, and the contents of each pointer are rewritten. A full statement of fee for compounding of medicines is produced to the T1 by reading the data on compounding of medicines stored in addresses between pointers 12a and 12b of the T1 out of a file 8 for compounding of medicine of each patient.
FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to ophthalmology. To produce a corneal graft for a layer-by-layer keratoplasty, treating the cornea of the donor eyeball with a solution containing riboflavin and dextran, subsequent ultraviolet (UV) radiation with wavelength of 370 nm, output 3 mW/cmwith simultaneous instillation containing riboflavin solution. For treatment, the corneal epithelium is removed with diameter of 10 mm. De-epithelised stroma of the cornea is followed by the installation of a solution containing, wt. %: riboflavin mononucleotide 0.14–0.15; dextran 18.0–22.0; tris-(hydroxymethyl)-methylamine 0.08–0.12; nipagin 0.0075–0.0125; Trilon B 0.005–0.01; sodium chloride 0.8–0.9 and distilled water purified to 100 for 40 minutes. UV radiation is performed with radiation fluence of 7.2 J/cmin pulsed accelerated mode: 1 s - light, 1 s is pause of 8 minutes with simultaneous instillation of the same solution, and the graft is formed with thickness of 125 ± 35 mcm, which is represented by a posterior portion of the stroma, a descemet membrane and an endothelium in its central part with a limbal-skeletal rim.EFFECT: method provides higher engraftment of the corneal graft, reduced antigenicity and potential risk of developing infectious complications in the postoperative period.1 cl, 1 ex
The invention relates to a B subgroup adenovirus 11 vector carrying IL-15R/IL-15 fusion genes and construction and application of the same. The promoter region of the virus E1A is replaced by telomerase gene promoters. The virus E318.5K is replaced by therapeutic genes mIL-15R/IL-15. The Ad11- Tel- mIL-15R/IL-15 vector which can be utilized for treating lung has specificity, safety and high effectiveness of lung cancer and can target tumors by the telomerase promoters with tumor specificity. The Ad11-Tel- mIL-15R/IL-15 vector adopts the highly-efficient fusion genes mIL-15R/IL-15 as the therapeutic genes and has tumor targeting and anti-tumor effects. The Ad11-Tel-mIL-15R/IL-15 vector lays the foundation for the transformation from recombinational gene engineering products to clinic and may provide lung cancer patients with an effective therapeutic method.
Procedure for obtaining fenilquinolicidinas, racemate or enantiomer and their salts addition acid of formula (I), wherein x, y, r and r can be various types of radical. It comprises reacting a compound oxo, of formula (II) wherein x, y, r, r and r have the same meaning as in the formula (I), phosphorus pentachloride. The reaction is carried out following conventional methods. The racematos obtained can be resolved in the optical antipodas. These compounds have pharmacological applications for their neuroletic, antimimetic and/or analgesic activities. (Machine-translation by Google Translate, not legally binding)
An excess of insulin relative to food intake, energy expenditure, or both may lead to severe and sometimes prolonged and life-threatening hypoglycemia and hypokalemia [see Warnings and Precautions (5.3, 5.6)]. Mild episodes of hypoglycemia usually can be treated with oral glucose. Lowering the insulin dosage, and adjustments in meal patterns or exercise may be needed. More severe episodes of hypoglycemia with coma, seizure, or neurologic impairment may be treated with a glucagon for emergency use or concentrated intravenous glucose. After apparent clinical recovery from hypoglycemia, continued observation and additional carbohydrate intake may be necessary to avoid reoccurrence of hypoglycemia. Hypokalemia must be corrected appropriately.
IMPORTANCE: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD.
OBJECTIVES: To perform the first large-scale X chromosome-wide association study (XWAS) of AD.
DESIGN, SETTING, AND PARTICIPANTS: This was a meta-analysis of genetic association studies in case-control, family-based, population-based, and longitudinal AD-related cohorts from the US Alzheimer's Disease Genetics Consortium, the Alzheimer's Disease Sequencing Project, the UK Biobank, the Finnish health registry, and the US Million Veterans Program. Risk of AD was evaluated through case-control logistic regression analyses. Data were analyzed between January 2023 and March 2024. Genetic data available from high-density single-nucleotide variant microarrays and whole-genome sequencing and summary statistics for multitissue expression and protein quantitative trait loci available from published studies were included, enabling follow-up genetic colocalization analyses. A total of 1 629 863 eligible participants were selected from referred and volunteer samples, 477 596 of whom were excluded for analysis exclusion criteria. The number of participants who declined to participate in original studies was not available.
MAIN OUTCOME AND MEASURES: Risk of AD, reported as odds ratios (ORs) with 95% CIs. Associations were considered at X chromosome-wide (P < 1 × 10-5) and genome-wide (P < 5 × 10-8) significance. Primary analyses are nonstratified, while secondary analyses evaluate sex-stratified effects.
RESULTS: Analyses included 1 152 284 participants of non-Hispanic White, European ancestry (664 403 [57.7%] female and 487 881 [42.3%] male), including 138 558 individuals with AD. Six independent genetic loci passed X chromosome-wide significance, with 4 showing support for links between the genetic signal for AD and expression of nearby genes in brain and nonbrain tissues. One of these 4 loci passed conservative genome-wide significance, with its lead variant centered on an intron of SLC9A7 (OR, 1.03; 95% CI, 1.02-1.04) and colocalization analyses prioritizing both the SLC9A7 and nearby CHST7 genes. Of these 6 loci, 4 displayed evidence for escape from X chromosome inactivation with regard to AD risk.
CONCLUSION AND RELEVANCE: This large-scale XWAS of AD identified the novel SLC9A7 locus. SLC9A7 regulates pH homeostasis in Golgi secretory compartments and is anticipated to have downstream effects on amyloid β accumulation. Overall, this study advances our knowledge of AD genetics and may provide novel biological drug targets. The results further provide initial insights into elucidating the role of the X chromosome in sex-based differences in AD.
Replace meals with a plant-based meal replacement and self-prepared Meditteranean meals for a max 1200 calorie per day. Enroll in a 12 week intensive lifestyle intervention program.