anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a making method for a sweet wine, especially a making method for a spleen invigorating and blood generating sweet wine. Traditional sweet wine is made from the single raw material glutinous rice, and based on glutinous rice, the raw materials of the sweet wine are added with longan pulp, dried red dates, and ginger brown sugar water. The wine has improved quality, and is not added with artificial synthetic pigment, spice, preservative or other chemical substances. Being sweet and mellow, and heavily fragrant, the sweet wine also has the due pleasant style of traditional sweet wine, and has the efficacy of invigorating spleen and generating blood, supporting Yang and strengthening energy, warming meridians and relieving pain. The making method includes: steaming glutinous rice, then spreading the glutinous rice, and stirring it loosely for cooling; loading the longan pulp and dried red dates (torn and pitted) into a container; scattering half of a bag of distiller's yeast by a small amount of cold boiled water; preparing ginger brown sugar water; adding the glutinous rice and distiller's yeast into the container loaded with the longan pulp and dried red dates, and mixing the materials evenly; digging a round hole at the center of the glutinous rice, and beating the glutinous rice around the round hole and on the upper surface flatly, then adding the ginger brown sugar water into the container; then spraying a small amount of the distiller's yeast of sweet wine on the glutinous rice surface, and covering the container with a lid. A few days later, the spleen invigorating and blood generating sweet wine can be obtained.
Subjects will undergo inhaled challenge, either with lipopolysaccharide or saline in a 2:1 ratio, prior to imaging assessments. Assessments will be performed during one study day on an outpatient basis.
Whenever possible, give infusions of epinephrine into a large vein. Avoid using a catheter tie-in technique, because the obstruction to blood flow around the tubing may cause stasis and increased local concentration of the drug. Avoid the veins of the leg in elderly patients or in those suffering from occlusive vascular diseases.

To provide hemodynamic support in septic shock associated hypotension in adult patients, the suggested dosing infusion rate of intravenously administered epinephrine is 0.05 mcg/kg/min to 2 mcg/kg/min and is titrated to achieve a desired mean arterial pressure (MAP). The dosage may be adjusted periodically, such as every 10 to 15 minutes, in increments of 0.05 mcg/kg/min to 0.2 mcg/kg/min, to achieve the desired blood pressure goal.

After hemodynamic stabilization, wean incrementally over time, such as by decreasing doses of epinephrine every 10 minutes to determine if the patient can tolerate gradual withdrawal.
Aim: This study investigated RAP1 immunostaining variation in different cell types during CC progression.Methods: Paraffin-embedded cervical tissues from 101 patients were categorized into control, pre-neoplastic and neoplastic groups. RAP1 immunolocalization, HPV detection and genotyping were performed. A semiquantitative immunoreactive score was employed to compare labeling intensity, cellular localization, nuclear labeling, percentage and distribution of reactive cells.Results: 73% (72/99) of cervical specimens were HPV+. RAP1 was localized in the nucleus and cytoplasm of all samples. Cytoplasmic RAP1 immunoscore was higher than nuclear score in all CC groups. RAP1 intensity increased with lesion severity. SCC samples exhibited predominantly intense RAP1 immunostaining.Conclusion: RAP1 is an efficient biomarker for detecting invasive CC lesions but has limited utility in distinguishing SCC grades.
Low molecular weight siloxane fluids are thickened by silicone elastomers. The silicone elastomers are made by crosslinking reactions of ≡Si-H containing siloxanes and an unsaturated hydrocarbon such as an alpha, omega-diene, in the presence of a low molecular weight siloxane fluid. The ≡SiH siloxane is first partially reacted with a mono-alkenyl functionalized polyether. It is then crosslinked by the alpha, omega-diene, in the presence of the low molecular weight siloxane fluid. An elastomer, i.e. gel, with polyether groups is produced. The elastomer can be swollen with the low molecular weight siloxane fluid under shear force, to provide a uniform silicone paste. The silicone paste has excellent spreadability upon rubbing and possesses unique rheological properties in being thixotropic and shear thinning. The silicone paste can be easily emulsified with water to form a stable uniform emulsion, without using a surfactant to allow normally immiscible materials to become intimately mixed.
OBJECTIVE: To determine the rate of nodal metastasis in dogs with thyroid cancer and evaluate whether immunohistochemistry (IHC) identifies additional metastases beyond evaluation with H&E.
ANIMALS: 70 prospectively enrolled client-owned dogs with thyroid cancer managed with thyroidectomy.
METHODS: Dogs underwent thyroidectomy with concurrent elective bilateral medial retropharyngeal (MRP) ± deep cervical lymphadenectomy. Thyroid tumors and associated lymph nodes were reviewed by a single board-certified pathologist. Immunohistochemistry was used for all primary tumors (thyroid transcription factor-1 and calcitonin) to support a diagnosis of follicular or medullary carcinoma. Lymph nodes without evidence of metastasis after H&E review were labeled with the antibody associated with the wider uptake in the primary tumor.
RESULTS: 77 thyroid cancers were resected from the 70 dogs enrolled, including 61 (79.2%) follicular, 8 (10.7%) medullary, and 7 (9.3%) mixed follicular/medullary carcinomas, with 1 (1.3%) carcinosarcoma. Twelve dogs had evidence of nodal metastasis following H&E review. Occult micrometastasis was identified in 1 dog following nodal IHC, resulting in documented metastasis in 13 of 70 (18.6%) dogs. Metastasis was more common with medullary (5/8) and follicular/medullary carcinoma (3/7) than follicular carcinoma (5/61). All MRP metastases were ipsilateral (7/77 [9.1%]), without contralateral MRP metastases (0/62). Fourteen of 41 (34.1%) deep cervical lymph nodes were metastatic.
CLINICAL RELEVANCE: Nodal metastasis was uncommon for follicular carcinoma but was seen in > 50% of dogs with thyroid cancer involving a medullary component. Routine nodal IHC appears to be low yield for thyroid carcinoma. Extirpation of ipsilateral MRP and identifiable deep cervical lymph nodes is recommended with thyroidectomy until detailed preoperative risk stratification becomes available.
The Chronic Kidney Disease Engagement System is currently in place for 1700 adults receiving care from Empire Physicians Medical Group (EPMG), an Independent Practice Association located in Palm Desert, California. The system monitors routine clinical laboratory test results and send messages to patients and providers when action is indicated, such as when tests are overdue or results require extra clinical attention. Patients receive first class letters directing them to call their provider. Providers receive fax or electronic messages directing them to reach out to the patient to arrange follow-up care. It has been used for over three years and appears to have improved adherence to Chronic Kidney Disease (CKD) treatment guidelines by influencing both patient and provider actions. EPMG wishes to restrict the service to those patients with advanced CKD and discontinue it for CKD stages 1-3. The investigators propose implementing this new policy in a randomized fashion with one half of the current early stage patients continuing to receive the service while the other half will no longer receive messages. The investigators will monitor laboratory results and health care utilization for both groups to determine what effect, if any, discontinuation has on quality of care.

Human subjects will either continue to receive letters from the service when their tests are overdue or require additional clinical attention, or will no longer receive the service. All subjects will continue to receive care from their providers. The main outcomes include the frequency of recommended tests for CKD, the level of those tests, and utilization of health care services as indicated by claims data provided by EPMG. No additional data collection will occur beyond that which has been routinely done for clinical care. The study will continue for 36 months.
A novel fibrinogen-based tissue adhesive patch is disclosed. The patch comprises a backing made from a non-permeable biocompatible polymer film into which a fibrinogen-based sealant is incorporated. In preferred embodiments of the invention, the fibrinogen-based sealant comprises fibrinogen, thrombin, and CaCl 2 . The polymer backing serves to seal the tissue to which the patch is applied, and the sealant acts only to bind the patch to the affected tissue. The patch does not include any mesh or woven component. Methods of production of the patch are also disclosed.
The subject invention relates to compositions and methods useful for the in vivo delivery of substantially water-insoluble drugs, like taxol. The use of specific composition and preparation conditions enables the reproducible production of unusually water-soluble formulation, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a re-dispersible dry powder comprising nanoparticles of drug. The innovation is also based on the fact that complementary partner is also an active drug but may have a different mode action with respect to primary molecule of the hybrid drug. The complementary molecule has multiple properties like antioxidant, antimicrobial, anti-inflammatory, anti-allergic, cox-2 inhibitors, etc. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable.
Pre-surgical evaluations (Six-minute walk test, sit and lift test 30 in seconds, and Piper fatigue scale) Intensity used will be mild / moderate, ie 60% of the maximum load reached in the incremental test. The pedaling speed should be maintained between 30-60rpm. The execution time, from this exercise regime will be 20 minutes, and assessments at discharge.
Participants performed a Low-load, high-rep resistance exercise (LL-HR) bout which includes a whole body resistance exercise bout, 3 sets at 30% maximum strength (1RM) for leg press, knee extension, hamstring curl, lat pulldown, shoulder press, chest press, 20-25 reps, last set to failure. 90mins following the exercise bout participants will undergo another oral glucose tolerance test.
The invention relates to an ScFv antibody VH-VL lambda 11 for resisting African swine fever virus and a preparation method thereof. The amino acid sequence of the heavy chain variable region of the ScFv antibody is shown in SEQ ID NO. 1, and the amino acid sequence of the light chain variable region of the ScFv antibody is shown in SEQ ID NO. 2. The invention separates lymphocytes from peripheral blood of naturally infected African swine fever immune tolerant pigs, extracts and separates total mRNA of the lymphocytes, obtains total cDNA fragments by an RT-PCR method, obtains a swine ScFv antibody gene sequence by an SOE-PCR method under the action of corresponding primers with Linker joints by taking cDNA as a template, constructs the ScFv antibody gene sequence to a PET-30a vector, converts BL21(DE3) competent cells, screens to obtain an ScFv antibody VH-VL lambda 11 aiming at African swine fever viruses, and performs primary activity identification on the screened ScFv antibody VH-VL lambda 11 to find that the antibody has African swine fever reaction activity. The invention provides a new material for early diagnosis and prevention and control of the African swine fever and provides a new technical support for controlling epidemic spread of the African swine fever as soon as possible.
This invention belongs to the field of medical technology and it can be used to perform personal halotherapy at room temperature in personal halotherapy assembly or in salt chamber in the treatment and prophylaxis of respiratory tract diseases, allergies and psoriasis, carried out in spas, health centres, sanatoria, hotels as well as at home or in outpatient health institutions. The salt aerosol in the salt chamber is mixed in a continuous process with freshly crushed salt crystals, thus saturating the salt aerosol with salt particles activated with kinetic energy. The therapy mode is adjusted in real-time in the course of the therapy process in the salt chamber by the operator or the patient with the help of the control desk. The personal halotherapy assembly is a small hermetically sealed salt chamber or salt capsule and is intended for one person or an adult along with a child. The whole dry salt aerosol saturation device along with the patient is in a hermetically sealed capsule ensures an individually prescribed and uniformly distributed environment of a salt aerosol, consisting of freshly ground dry salt crystals of NaCl with a size of 0,5-5 μm at a concentration of 0,5-80 mg/m3, around the body of the patient during a 10 to 45 minute salt procedure. During the performance of a salt procedure, the salt capsule is hermetically isolated from the surrounding environment and the saturation of the salt aerosol is carried out autonomously. The control desk (5)is duplicated to the lower part (A) of the personal therapy assembly as well as to the personal console of the patient in the salt therapy room (C). The personal halotherapy assembly may be equipped with wheels that make it easy to transport.
PURPOSE:To provide the cultured fish treatment agent containing a cyanine pigment having a nitrogen-containing heterocyclic nucleus such as benzothiazole, benzoselenazole, pyridine, etc., as an active component, and effective to accelerate the intrinsic respiration and promote the growth of the fish at an extremely, low dose. CONSTITUTION:A cyanine pigment such as the compound of formula I (the group of formula II and formula III is a nitrogen-containing heterocyclic nucleus such as benzothiazole, benzoselenazole, benzoxazole, naphthothiazole, thiazole, pyridine, etc.; R1-2 are residue of quaternarizing agent minus anion; n is 0 or positive integer) as an active component. A concrete example of the compound is the compound of formula IV. It accelerates the intrinsic respiration of fish, develops its strength and promotes the healthy growth of fish at an extremely low dose. For example, it resists to the diseases with viruses such as IPN, IHN, etc., accelerates the remedy of wound of the skin, prevents the parasitism of water mildew, and improves the yield of the cultured fish. There is no adverse effect to the quality of water or the fish.
In addition to medication using SSRIs, patients will be also treated with Neuro-Training. The process will be guided under fNIRS and monitored by EGG. Treatment will last 4 weeks.
There is proposed herein a process for production of composite antimicrobial and vulnerary preparations for external administration, featuring a higher therapeutic efficiency in case of skin and soft tissues infections treatment. The proposed compositions include an active agent being fosfomycin and finely dispersed nanostructured silica dioxide, with a weight ratio of (25-75 mass. %):(75-25 mass. %) respectively. The mentioned production process includes mixing fosfomycin with finely dispersed nanostructured silica dioxide. The process is distinct in that the mixture of aforementioned substances with the mentioned weight ratio is exposed to mechanical processing by blow impact and abrasive actions until a portion of the fine powder fraction with particles smaller than 5 micrometers, contained in the mixture, increases to at least 40%.
UNLABELLED: Understanding the cardiac risks of antipsychotic use is crucial for clinicians managing psychiatric conditions in children and adolescents. However, the effects on the QT interval in pediatric populations have been poorly investigated. We performed a systematic review to provide clinicians an updated source on the effects of antipsychotic medications on QTc and guide drug's choice. A literature search on the PubMed and Scopus databases was conducted from April 22, 1989, to May 28, 2023, for all studies investigating the effects of antipsychotic medications on the QTc interval in patients aged 0-18 years. A total of 10 articles including 523 patients and 7 different antipsychotic drugs met our search criteria. Among the included articles were three randomized clinical trials, five controlled trials without randomization or prospective comparative cohort trials, and two retrospective cohort studies. Clinical data emerging from these studies were classified according to the Oxford Centre for Evidence-Based Medicine. Risperidone and aripiprazole showed minimal to no significant QTc prolongation, whereas quetiapine, olanzapine, and ziprasidone showed variable effects on QTc. Haloperidol did not demonstrate significant QTc prolongation. In a prospective comparative cohort trial, pimozide exhibited significant QTc prolongation in a cohort with Tourette syndrome.
CONCLUSION: Only 10 studies have carefully addressed the effect of antipsychotic medications on QTc among pediatric patients, underscoring the need for further research. Personalized risk assessment and regular cardiac monitoring should be integrated into clinical management of pediatric and adolescent patients receiving antipsychotics to facilitate early detection of repolarization abnormalities and potential intervention.
WHAT IS KNOWN: • QT interval prolongation is a reported side effect of antipsychotics among adults especially with first-generation antipsychotics and parenteral infusion. • Understanding the effect of antipsychotics on QT is essential for clinical monitoring and avoidance of complications.
WHAT IS NEW: • Risperidone and aripiprazole were the most studied antipsychotics in pediatric patients and showed minimal QT prolongation. • The absence of a standardized protocol for assessing the effects on the QT interval makes comparisons between studies challenging and emphasizes the need for further research.
Participants receive placebo to MK-1167 oral QD from Days 1 to 31. Participants also receive 10 mg oral Donepezil QD on Days -3 to 31.
In the oropharyngeal rehabilitation (OPR) group, the participants will receive 12-week OPR. The OPR for the OPR group included three 30-minute sessions of OPR per day, and the exercise would be performed 3-5 days per week for 3 months. The performance of the home exercise will also be recorded by the force-sensing resistor. In addition to home exercise sessions, there will also be twice-weekly clinical visits to adjust the contents of OPR program and monitor training progress. To evaluate the effect of treatments on the severity of OSA, tongue muscle strength and the space of the upper airway, the participants will receive polysomonogrphy test, tongue muscle strength test and computed tomography. The time of evaluation will include baseline, 3 and 6 months after treatment.
<P>PROBLEM TO BE SOLVED: To provide a wound covering material, in which exudate such as viscous fluid and blood from a wound is sufficiently absorbed, and of which an application surface is so smooth that the surface of the wound is less stimulated when it is applied, and a method for manufacturing the same.  <P>SOLUTION: The wound covering agent comprises a sheet-shaped article as a layered combination of a water absorption layer comprising dried matter of gel containing water-soluble high polymer of molar weight of 50,000 or more with cloth. The water soluble high polymer contains mannan. The cloth is embedded on one surface side of the water absorption layer in an anchoring way, except one surface side of the cloth. The other surface of the water absorption layer is exposed on one surface of the sheet-shaped article, and the other surface of the water absorption layer is a releasable surface. In the wound covering material, the water absorption layer includes water-soluble polysaccharides of 30-70 wt.%, and water-soluble nonvolatile organic compound of molar weight of less than 50,000 of 30-55 wt.%. Preferably, 30-90 wt.% of the water-soluble polysaccharides is mannan.  <P>COPYRIGHT: (C)2011,JPO&INPIT
BACKGROUND: Asthma is a disease characterized by airway hyperresponsiveness and airway inflammation. Icaritin (ICT) is a plant hormone with various pharmacological activities such as anti-inflammatory, immune regulation, and anti-tumor. This study mainly explored the effects of nebulized inhalation of ICT on airway inflammation and airway remodeling in asthmatic mice.
METHOD: Different groups of ovalbumin (OVA)-induced asthma mice with acute and chronic airway inflammation received ICT. Asthmatic mice received budesonide (BDND) aerosol inhalation as a positive control, while normal control and asthma model mice received the same volume of saline. Following finishing of the study, analyses were conducted on behavioral tests, biochemical indices, and histological structures of lung tissues.
RESULTS: Aerosol inhalation of ICT can notably reduce inflammatory cells infiltration around the airways and pulmonary vessels, and suppressed goblet cell hyperplasia in asthmatic mice. Long-term inhalation of ICT can decrease airway collagen deposition and airway smooth muscle hyperplasia, and alleviate airway hyperresponsiveness, mirroring the effects observed with hormone employed in clinical practice.
CONCLUSION: Nebulized inhalation of ICT can effectively inhibit airway inflammation in asthmatic mice, improve airway remodeling, and reduce airway hyperresponsiveness, with effects similar to those of hormones. It may serve as a potential candidate used as a hormone replacement asthma treatment.
The infusions will be administered at the selected medical center or in the home care setup. The dose of intravenous (IV) infusions of Elelyso will be the same dose of the other ERTs . Bone parameters QCSI and BMD will be assessed at baseline, 12 months and 24 months.
An invention is afforded for providing ongoing health facility risk assessment. The invention includes subdividing a facility into a plurality of compartments, wherein each compartment defines a portion of the facility. A risk assessment score is assigned and stored in a database to each inspection point. The risk assessment score is a number indicating an importance and potential harm created when the inspection point fails inspection, and wherein each inspection point indicates a requirement of an element of performance (EP). During inspections, a sum of all risk assessment scores associated with failed inspection points within a particular compartment is calculated. When the sum is greater than a predetermined threshold value for the compartment, an Interim Life Safety Measure (ILSM) is issued by selecting a plurality of ILSM actions from a previously stored list and correlating them with the type of deficiencies to generate, document, and validate steps taken as Interim Life Safety Measures.
The initial starting dose of PEP02 is 60 mg/m2, and was escalated by increments of 20 mg/m2 between dose levels. 5-FU and LV were given as 24-hour infusion via an implanted central venous catheter, with dose fixed at 2000 mg/m2 and 200 mg/m2, respectively. PEP02 was administered on Day 1; 5-FU/LV was started after the end of PEP02 infusion on Day 1 and also on Day 8.
The AM group will be subjected to a diagnostic arthroscopy with a full inspection of the knee joint to ensure the inclusion criteria are fulfilled. The cartilage is cut sharp forming a rim of 90 degrees. The calcified layer is removed using a curette before an arthroscopic awl is then used to perform multiple holes ("microfractures") from the periphery towards the center. The microfractures are 3 - 4 mm apart and 2 - 4 mm deep into the subchondral bone. The correct and successful technique is confirmed by direct visualization: while reducing the fluid pump pressure, the release of marrow fat droplets and blood will be observed.