anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Stoma site incisional hernias (SSIHs) are associated with substantial long-term morbidity, and the rate can be as high as 30% to 40%. Recent efforts using prophylactic mesh reinforcement (PMR) to reduce the development of hernias have shown encouraging outcomes. The objective of this study was to assess the use of prophylactic biosynthetic mesh at the time of stoma reversal on the overall SSIH rate.
METHODS: This is an observational retrospective cohort study. A review of 101 consecutive patients who underwent PMR in the retrorectus plane from 2015 to 2020 was compared to 73 consecutive patients who underwent primary stoma closure without mesh from 2011 to 2014. The primary endpoint was the presence of SSIH on clinical examination or computed tomography after ostomy takedown.
RESULTS: In total, 174 cases were analyzed with 101 patients in the treatment group (median follow-up 45.2 months) and 73 patients in the control group (median follow-up 43.2 months). There were no major differences in preoperative characteristics between the groups. Fourteen patients developed SSIHs with 1 (1.0%) in the treatment arm and 13 (17.8%) in the control arm (p = 0.001). The majority of stomas were loop ileostomies and end colostomies, and stoma type did not affect hernia rates. On univariate analysis, body mass index (p = 0.029) and chronic kidney disease < 3 (p = 0.003) were independent predictors of hernia formation, while mesh was significantly protective (p = 0.000057).
DISCUSSION: PMR with biosynthetic mesh at the time of stoma reversal and closure is an effective procedure to reduce the incidence of SSIHs and does not seem to be associated with an increased risk of complications.
ER+HER2+ breast cancer have low response to single endocrine therapy, however the efficacy was improved when treated with endocrine therapy combined with anti-HER2 target therapy. Palbociclib, to be a CDK4/6 inhibitor, has synergistic with tamoxifen and trastuzumab in ER+/HER2+ cells. In China, there is nearly 40000 new patients with ER+/HER2+ breast cancer every year. The encouraging results in NA-PHER2 study suggested the triple targeting of ER, HER2, and RB1 could be an effective chemotherapy-free treatment strategy in neoadjuvant therapy. However, pertuzumab is very expensive. The investigators plan to replace pertuzumab with pyrotinib. Pyrotinib, a new irreversible pan-Her inhibitor in China pharmaceutical company. The objective is to evaluate the efficacy and safety of Neoadjuvant treatment with trastuzumab and pyrotinib plus palbociclib and fulvestrant (TPPF) in this target population. 37 patients will enter the single-arm treatment group. The participants will receive an association of drugs (trastuzumab, pyrotinib, palbociclib plus Fulvestrant, TPPF) as neoadjuvant therapy. Surgery will be performed not earlier than 14 days and not later than 28 days after the last dose of any of the drugs in the combination. The primary endpoint is the rate of pathological complete response (pCR) defined as ypT0-ypTis ypN0 at surgery. The secondary endpoint include the change in Ki67 expression from baseline and at C2D15 of treatment and at surgery, objective response rate and safety.
Sepsis is a prevalent critical illness observed in emergency intensive care unit (ICU), characterized by life-threatening organ dysfunction caused by infection-induced inflammatory immune disorders in the body. The suppression of immune function plays a crucial role in the development and progression of sepsis. Traditional Chinese medicine theory of "acute deficiency syndrome" in sepsis shares similarities with the concept of "immunosuppression". According to this theory, ginseng is frequently utilized in clinical treatment of sepsis due to its ability to invigorate vitality and strengthen the body, playing a crucial role in tonifying deficiency and improving the overall health of patients. This paper provides a detailed discussion of the pathophysiological mechanisms of sepsis immune dysfunction and its correlation with "acute deficiency syndrome" in traditional Chinese medicine. It summarizes the current state of modern pharmacological research on ginseng's impact on the body's immune function, discusses relevant research progress and shortcomings regarding ginseng's therapeutic effects on immunosuppression in sepsis, and proposes future research directions.
Patients will be enrolled before cardiac surgery with cardiopulmonary bypass (CPB) and monitored until after the surgery. Patients enrolled will undergo diffusion weighted magnetic resonance imaging and will be administered with cognitive tests one day before surgery and within one week after surgery. Cerebral blood flow velocity as derived from transcranial Doppler recordings will be acquired from the middle cerebral artery synchronously with arterial pressure, invasively derived from the radial artery, and with the electrocardiogram as derived from patient's monitor. Signals will be acquired before anesthesia induction (BASAL), after anesthesia induction and intubation of the chest (ANESTH) and during CPB (CPB). Each acquisition will last at least 5 minutes and will be prolonged to the maximum possible length in keeping with clinical scheduling. Partial pressure of carbon dioxide and other clinical parameters will be acquired too during the intervention.
OBJECTIVE: Aim: The aim of this article is to present and discuss the conclusions of a fi nalized pilot project implementing telemedical solutions for COPD management within the senior population in Wrocław and the Lower Silesian Voivodeship during 2022-2023. It also aimed to contribute to the development of innovative strategies to improve care for individuals with COPD through the use of telemedical technologies.
PATIENTS AND METHODS: Materials and methods: An interdisciplinary and comprehensive pilot project in pulmonology was applied, dividing it into health, organizational, and tech-nological areas. The steps and data collection strategy were presented, enabling the implementation of telemedical solutions among COPD patients in Poland.
RESULTS: Results: The implementation of telemedical solutions in COPD represented an innovative approach to improving care. Among the main goals of the project were to reduce patient waiting times, enhance disease progress monitoring, and provide access to specialized healthcare through the use of modern telemedical technologies. Various telemedical solutions were implemented, including remote monitoring of health parameters, online consultations with pulmonology specialists, and patient education on self-monitoring of symptoms. The fi nal summary of the materials collected within the described methodology allowed for a holistic view of the implementation of telemedicine in pulmonary healthcare in Poland, using the discussed pilot project as an example.
CONCLUSION: Conclusions: The analysis of the pilot project implementing telemedical solutions in the fi eld of pulmonology in the Polish healthcare sector has shown that telemedicine can improve care for COPD patients. The project's outcomes indicate the potential for reducing patient waiting times and better monitoring of disease progression. However, these aspects require improvement and ref i nement, particularly in terms of systemic solutions.
Alzheimer's disease (AD) involves aggregation of amyloid β and tau, neuron loss, cognitive decline, and neuroinflammatory responses. Both resident microglia and peripheral immune cells have been associated with the immune component of AD. However, the relative contribution of resident and peripheral immune cell types to AD predisposition has not been thoroughly explored due to their similarity in gene expression and function. To study the effects of AD-associated variants on cis-regulatory elements, we train convolutional neural network (CNN) regression models that link genome sequence to cell type-specific levels of open chromatin, a proxy for regulatory element activity. We then use in silico mutagenesis of regulatory sequences to predict the relative impact of candidate variants across these cell types. We develop and apply criteria for evaluating our models and refine our models using massively parallel reporter assay (MPRA) data. Our models identify multiple AD-associated variants with a greater predicted impact in peripheral cells relative to microglia or neurons. Our results support their use as models to study the effects of AD-associated variants and even suggest that peripheral immune cells themselves may mediate a component of AD predisposition. We make our library of CNN models and predictions available as a resource for the community to study immune and neurological disorders.
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to urology. Method involves endoscopic recanalization of the posterior urethra with introducing into the urethra a suspension of a fragmented autograft of buccal mucosa and a fibrin-thrombin glue. Area of the buccal mucosa Sb taken up is 1/6 of the surface area of the wound surface in the urethra after recanalization of Su; the area Su is calculated by formula: Su=πl, where l is length of obliteration in cm, determined radiologically +1 cm, area Sb is rounded to tenth of obtained value. Produced flap of buccal mucosa is washed in a solution of antibiotics with volume of 2 ml. Flap is fragmented to particles sized to 1 mm; the graft fragments in the antibiotic solution are subjected to centrifugation in mode of 1,700 rpm for 5 minutes. Obtained precipitate is resuspended in 1 ml of said antibiotic solution and divided into 2 parts, each of which is mixed with one of two components of fibrin-thrombin glue, equal in volume, wherein total volume of glue is calculated by formula: V=0.18πl, where l is length of obliteration in cm, determined radiologically +1 cm, performing endoscopic recanalization of posterior urethra, installing urethral catheter with diameter of 16 Ch, parallel to urethral catheter to incision is a two-way ureteral catheter, through which two components of glue with a suspension of buccal mucosa fragments are simultaneously introduced by two syringes, the urethral catheter is removed 28 days after the operation.EFFECT: method provides higher effectiveness and reduced intraoperative injuries ensured by minimally invasive intervention and formation of a whole, seam-free fragment of neo-urethra in postoperative recovery.1 cl, 3 dwg, 1 ex
Disclosed is an antibacterial functional lotion composition with excellent antibacterial persistence. The antibacterial functional lotion composition comprises a base lotion component and an antibacterial essential oil component mixed with the base lotion component, wherein the antibacterial essential oil component includes Melissa officinalis leaf oil. In addition, the antibacterial essential oil component further includes at least one of thyme oil, clove leaf oil, and cinnamon bark oil. In the antibacterial essential oil component, the weight ratio (A : B) of the Melissa officinalis leaf oil (A) and the thyme oil (B) is about 1 : 4 to 4 : 1. In the antibacterial essential oil component, the weight ratio (A : C) of the Melissa officinalis leaf oil (A) and the clove leaf oil (C) is about 1 : 4 to 4 : 1. In the antibacterial essential oil component, the weight ratio (A : D) of the Melissa officinalis leaf oil (A) and the cinnamon bark oil (D) is about 1 : 4 to 4 : 1. In the antibacterial essential oil component, the weight ratio [A : (B + C + D)] of the Melissa officinalis leaf oil (A) and the total amount of the thyme oil (B), the clove leaf oil (C), and the cinnamon bark oil (D) is about 1 : 4 to 4 : 1.
Apparatus and methods comprise examination of a subject using images of the subject. The images can provide a non-invasive analysis technique and can include a plurality of images of a portion of the subject at different times a temperature stimulus applied to the subject. An image of the portion of the subject can be aligned such that each pixel of the image corresponds to the same point on the subject over a sequence of images of the portion. The sequence of images can be processed after aligning the images such that data is extracted from the images. The extracted data can be used to make decisions regarding the health status of the subject. Additional apparatus, systems, and methods are disclosed.
In the controlled portions of the clinical trials in Dupuytren’s contracture (Studies 1 and 2), a greater proportion of XIAFLEX-treated patients (15%) compared to placebo-treated patients (1%) had mild allergic reactions (pruritus) after up to 3 injections. The incidence of XIAFLEX-associated pruritus increased after more XIAFLEX injections in patients with Dupuytren’s contracture. 

In the double-blind, placebo-controlled portions of the clinical trials in Peyronie’s disease (Studies 1 and 2), a greater proportion of XIAFLEX-treated patients (4%) compared to placebo-treated patients (1%) had localized pruritus after up to 4 treatment cycles (involving up to 8 XIAFLEX injection procedures). The incidence of XIAFLEX-associated pruritus was similar after each injection regardless of the number of injections administered.

Because XIAFLEX contains foreign proteins, severe allergic reactions to XIAFLEX can occur. Anaphylaxis was reported in a post-marketing clinical trial (Study 3) in one patient who had previous exposure to XIAFLEX for the treatment of Dupuytren’s contracture. Some patients with Dupuytren’s contracture developed IgE-anti-drug antibodies in greater proportions and higher titers with successive XIAFLEX injections. Healthcare providers should be prepared to address severe allergic reactions following XIAFLEX injections.
The invention discloses an abrasion-resisting foot protecting agent and a preparing method thereof. The abrasion-resisting foot protecting agent comprises, by weight, 40-70 parts of hydrogenated vegetable oil, 10-40 parts of medium alkanol, 2-10 parts of shea butter, 10-30 parts of plasticizer, 0.1-1 part of antiseptic substance and 0.1-1 part of essence. According to the feature of foot abrasion, through well-designed design and experiments, a brand-new mode is used. and foot abrasion and blisters are avoided. Before high-heeled shoes are worn, a small quantity of the agent is smeared to easily-abraded parts of feet, and a colorless invisible protecting layer is formed, so that direct friction between the shoes and the skin is avoided, and scratching and blisters are avoided. Meanwhile, the abrasion-resisting foot protecting agent has the function of moistening the foot skin, and foot abrasion is further prevented.
Cardiovascular disease is the leading cause of death in women. It remains underdiagnosed, undertreated, and portends worse outcomes in women than men. Disparities exist in every stage of science, from bench research to the editorial board of major journals and in every cardiovascular subspecialty. This review summarizes differences in cardiovascular risk factors and disparities in management and outcomes of ischemic heart disease, heart failure, aortic stenosis, and atrial fibrillation. It also provides an overview of female representation as participants and leaders of clinical trials, editorial boards, and academic institutions. Strategies to overcome these disparities are proposed with examples of successful programs.
XL281 administered once a day. Subjects in this arm will be dosed under fed conditions, fasted conditions, and with a concomitant single dose of 40 mg famotidine, during the second, third, and fourth week of the first cycle.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by pulmonary fibroblast overactivation, resulting in the accumulation of abnormal extracellular matrix and lung parenchymal damage. Although the pathogenesis of IPF remains unclear, aging was proposed as the most prominent nongenetic risk factor. Propionate metabolism undergoes reprogramming in the aging population, leading to the accumulation of the by-product methylmalonic acid (MMA). This study aimed to explore alterations in propionate metabolism in IPF and the impact of the by-product MMA on pulmonary fibrosis. It revealed alterations in the expression of enzymes involved in propionate metabolism within IPF lung tissues, characterized by an increase in propionyl-CoA carboxylase and methylmalonyl-CoA epimerase expression, and a decrease in methylmalonyl-CoA mutase expression. Knockdown of methylmalonyl-CoA mutase, the key enzyme in propionate metabolism, induced a profibrotic phenotype and activated co-cultured fibroblasts in A549 cells. MMA exacerbated bleomycin-induced mouse lung fibrosis and induced a profibrotic phenotype in both epithelial cells and fibroblasts through activation of the canonical transforming growth factor-β/Smad pathway. Overall, these findings unveil an alteration of propionate metabolism in IPF, leading to MMA accumulation, thus exacerbating lung fibrosis through promoting profibrotic phenotypic transitions via the canonical transforming growth factor-β/Smad signaling pathway.
PURPOSE: To obtain arteriosclerosis suppressor containing an anti-endothelial cell growth factor as an active ingredient and preventing arterialization in arteriosclerosis nest. CONSTITUTION: This suppressor contains an anti-endothelial cell growth factor (anti-VEGF) as an active ingredient. A human-derived polyclonal antibody, monoclonal antibody, etc., is used as an antibody against VEGF. The agent is preferably parenterally administered and the daily dose is 0.5-10mg/kg. day as a composition composed of the effective amount of VEGF monoclonal antibody and a proper diluent and a carrier pharmacologically usable carrier. The anti-VEGF antibody is useful as a diagnosing agent for arteriosclerosis and can detect VEGF in arteriosclerosis nest. The polyclonal antibody is obtained by expressing cDNA of VEGF isolated from human front myelocytic leukemia cell HL-60 as a fused protein with glutathione S-transferase in Escherichia coli to afford a protein used as an antigen and using the resultant protein as an antigen and preparing according to an ordinary method.
A microorganism belonging to Beauveria sp. and being capable of producing FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366, FERM BP-08459) is cultured in a medium and thus the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are accumulated in the culture medium. Then the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are collected from the culture medium. The thus obtained FKI-1366 substance A, FKI-1366 substance B and FKI-1366 substance C or compositions thereof have an effect of potentiating the activity of azole antifungal agents. Thus, they act against various fungal infections such as deep-seated fungal infection at a low concentration and within a short time. Therefore, they are useful in lowering the appearance frequency of tolerant strains and overcoming tolerance, thereby being expected as useful drugs.
BACKGROUND: Metabolic and bariatric surgery (MBS) is the most effective treatment for obesity and improvement of obesity-associated comorbidities. However, a proportion of these patients may suffer from weight recurrence and recurrence of obesity-associated comorbidities.
METHOD: A retrospective cohort study of patients who underwent SG between January 2008 and August 2022 and sought treatment for weight recurrence with semaglutide or tirzepetide from January 2022 onwards.
RESULT: A total of 115 patients were included, of which 70 had SG and treated for weight recurrence with semaglutide and 45 had SG and treated with tirzepatide. The mean age of patients was 38.8 (10.4) and 80.9% of patients were female. The mean pre-treatment weight and BMI was 94.0 (23.8) kg and 35.1 (6.0) kg/m2. Following treatment with semaglutide and tirzepatide, the mean post-treatment weight at 6 months was 81.0 (19.0) kg from 90.1 (19.6) kg and 87.6 (28.3) kg from 100.2 (28.5) kg respectively, corresponding to a clinically significant mean weight loss from baseline to 6 months of 10.3 (5.9)% (p < 0.05) and 15.5 (6.3)% (p < 0.05). Weight loss in tirzepatide patients was significantly greater than the semaglutide patients at 6 months (p < 0.02). There were no reported severe adverse events to the treatment.
CONCLUSION: Short-term outcomes show that semaglutide and tirzepatide can be an effective treatment for managing weight recurrence after SG. Studies with longer follow-up are needed to determine the durability, as weight regain after discontinuation of the medication is highly likely, and the high cost of these medications can limit their use.
The primary cause of mortality in colorectal cancer (CRC) patients is tumor metastasis. The epithelial-mesenchymal transition (EMT) stands out as a crucial factor promoting the metastasis of CRC. Previous findings suggest a potential inhibitory effect of docosahexaenoic acid (DHA) on CRC metastasis, but the precise mechanism remains unknown, this study aims to explore this issue. We assessed metastasis and recurrence, all-cause mortality, and cancer-related mortality rates according to DHA intake in independent CRC cohorts (n = 367) by survival analysis. The ability of DHA to block CRC cell migration and invasion was tested using transwell and wound-healing assays. The regulation of EMT marker genes in CRC by DHA was detected by quantitative real-time PCR (qPCR) and immunoblotting, and the effect of DHA on the TGF-β1/Smad signaling pathway was further investigated. These cellular findings were validated using a subcutaneous CRC mouse model. Survival analyses showed that lower DHA intake was associated with a higher risk of CRC metastasis and a poorer prognosis. In vitro experiments showed that DHA inhibits the TGF-β1/Smad signaling pathway and regulates downstream transcription factors, thereby reversing the EMT and inhibiting invasion and migration. In the mouse model, dietary DHA supplementation effectively increased blood DHA concentrations and inhibited CRC metastasis. Our study demonstrated that DHA inhibits CRC invasion and metastasis by inhibiting the TGF-β1/Smad signaling pathway. Increased intake of DHA among CRC patients may provide additional benefits to the prognosis of colorectal cancer.
Under-perception of asthma symptoms in children is a major risk factor for emergency department visits, hospitalizations, and near-fatal/fatal asthma attacks. Puerto Rican and Black children have greater asthma morbidity and mortality rates than all other racial/ethnic groups. Interventions targeting asthma symptom perception and medication adherence may help close this asthma health disparities gap.

The baseline visit for all families consists of standardized asthma education followed by 3 weeks of PEF prediction without feedback using a programmable, electronic spirometer. Participants then will be randomized to intervention group or control feedback group and receive a brief feedback session. For the next 6 weeks, all adolescents will predict their PEF, which will be locked in before blowing into the device. Families will return at mid-intervention and post-intervention to receive feedback sessions. All adolescents will play an interactive asthma educational game to reinforce the baseline asthma education. At the post-intervention visit, the spirometer will be reprogrammed for the next 4 weeks. These symptom perception data will be downloaded at 1-month post-intervention. Controller medication adherence will be monitored by electronic devices. Post-intervention sessions will take place at 3, 6, 9, and 12 months to collect adherence data and conduct spirometry. Physicians will be blinded to group assignment and rate asthma severity using national guidelines. A 12-month retrospective medical record abstraction will compare emergency health care use for asthma between groups.