anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A nanocomposite material and a preparation method therefor and use thereof. The nanocomposite material uses a platelet membrane as a shell to wrap Prussian blue nanoparticles. The surface of the platelet membrane is modified with aptamers of cancer cells and horseradish peroxidase. According to the nanocomposite material, by using the ability of platelets to specifically target cancer cells and inflammatory sites, the accumulation of nanoparticles at tumor sites can be effectively enhanced, and Prussian blue-based photothermal therapy is achieved under the irradiation of near-infrared light. The horseradish peroxidase modifying the surface of the nanocomposite material can decompose hydrogen peroxide to generate oxygen bubbles to drive active transport of nanocomposites, and the accumulation of the nanocomposite material in the cancer cells is enhanced. The surface of the platelet membrane is modified with the aptamers of the cancer cells, so that the targeting effect on the cancer cells is enhanced.
PROBLEM TO BE SOLVED: To produce a readily drinkable nourishing supplementary food utilizing Lentinus edodes Sing. abundantly containing various nutrients and provide a method for producing the food without deteriorating and reducing the contained ingredients. SOLUTION: This tablet comprises ingredients of Lentinus edodes Sing., a shape retaining agent and a shape stabilizer. The moisture content is regulated to a prescribed value. The tablet of the Lentinus edodes Sing. of a prescribed shape and size is obtained by mixing the ingredients of the Lentinus edodes Sing. with the shape retaining agent and shape stabilizer, drying the resultant mixture at a relatively low temperature, regulating the moisture content to the prescribed value, then cooling the regulated mixture to normal temperatures and subsequently compression forming the cooled mixture.
Composition (A) for treating malignant myeloma, by activating an antitumor immune response through stimulation of the NKG2D receptor, comprises the protein ULBP2 (UL16-binding protein 2)/anti-CD138 (I), in a carrier material. An independent claim is also included for use of ULBP2-encoding DNA or RNA for preparing a construct analogous to (I) but with the CD138-binding component replaced by an antibody fragment directed against another selected tumor antigen (Ag) for treating malignant disease in which Ag is expressed. ACTIVITY : Cytostatic. Natural killer (NK) cells from healthy donors were used as effector cells (EC) in a europium-release assay. Target cells (TC) were human multiple myeloma cells U266 and were labeled with Eu; then incubated with NK and the amount of EU released into the supernatant determined as a measure of NK-induced tumor cell lysis. In presence of 5 mu g/ml of the fusion protein between ULBP2 and anti-CD138 single-chain antibody fragment, lysis was 50% at EC:TC ratio 10:1; compare 30% for 15 mu g/ml of the antibody fragment alone. A similar result was found for RPMI-8226 cells, also positive for CD138, but not for 293T cells, negative for CD138. MECHANISM OF ACTION : Activation of an anti-tumor immune response by stimulation of the NKG2D receptor (present on natural killer cells, for which ULBP2 is a ligand), resulting in lysis of target cells.
This retrospective study examines the surgical and antibiotic treatment of diabetic foot syndrome infections treated at the University Hospital Basel since 2019. (In 2019 the departments of infectiology and orthopedics at the University Hospital Basel published recommendations with regard to the duration of antibiotic therapy in infections of the diabetic foot syndrome. This depends on whether a surgical intervention was performed and takes into account both the microbiological and the histopathological samples). Data that are routinely collected in everyday clinical practice and stored in the hospitals' medical records will be evaluated. The aim of this research project is to check the implementation of these recommendations.

Inadequate use of antibiotics should thus be recognized. The study has the aspect of quality control.
Group B: 18-30 years old, who did not receive the 20l2-2013 seasonal influenza vaccine. Given intramuscular,inactivated influenza vaccine-trivalent (IM IIV3) - Fluzone.
PROBLEM TO BE SOLVED: To have steady abundance of salicylic acid glycol in a sacciform body even in long-term preservation by enclosing a sacciform body and a plaster in wrapping whose top internal layer is made of one or more than two kinds of polyolefin, polyacrylonitrile and denatured PET. SOLUTION: A plaster is made of a sacciform body and a support. Combining water and salicylic acid glycol, which is widely used as embrocation, makes the sacciform and the support's contacting part with the sacciform is made of polypropylene. The plaster is enclosed in wrapping whose top internal layer is made of one or more than two kinds of polyolefin, polyacrylonitrile and denatured PET. In this case, an ideal combination quantity of salicylic acid glycol is 0.5% to 2% of the sacciform body's weight, and an ideal quantity of water is 40% to 85% of the sacciform body's weight. Ideal wrapping's top internal layer is Polyethylene and it has thickness of 20 μm to 40 μm. One provided with aluminum evaporated film layer is deal as a wrapping material.
PURPOSE:To improve softness for the absorption of the oozing tissue liquid and improve the adhesiveness with a broken surface and accelerate the skin formation by carrying out the reducing agent treatment after the reconstruction of a soluble collagen into tissue and carrying out preparation by introducing bridges in artificial ways according to necessity. CONSTITUTION:Soluble collagen, and collagen from which the hetero peptide in the particle terminal part is removed, or the collagen added with the joining composition, e.g., bone forming protein, hyaluronic acid, chondroitin sulfate, viscous protein fibronectine, osteonectine, etc. is dissolved into a neuitrallizing buffer solution, and the pH is adjusted to neutral. Said solution is filtered and sterilized, and poured into a flat plate vessel placed horizontally, and formed into a gel form. The obtained gel is kept in the neutral buffer solution, and treated by the weak reducing agent such as hydrogenated boric composition, preferably the hydrogenated sodium borate. In order to increase the strength and softness of a bridged collagen sheet 6, bridge is introduced in artificial ways by the bridging agent such as hexamethylene diisocyanate, besides the stabilization of the biological bridge by the reducing agent.
Patients receive temsirolimus IV over 30-60 minutes and cetuximab IV over 1-2 hours once weekly. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
BACKGROUND: Acute pancreatitis (AP) is a potentially lethal acute disease highly involved in coagulation disorders. Pyroptosis has been reported to exacerbate coagulation disorders, yet this implication has not been illustrated completely in AP.
METHODS: RNA sequencing data of peripheral blood of AP patients were downloaded from the Gene Expression Omnibus database. Gene set variation analysis and single sample gene set enrichment analysis were used to calculate the enrichment score of coagulation-related signatures and pyroptosis. Spearman and Pearson correlation analysis was used for correlation analysis. Peripheral blood samples and related clinical parameters were collected from patients with AP and healthy individuals. A severe AP (SAP) model of mice was established using caerulein and lipopolysaccharide. Enzyme-linked immunosorbent assay, chemiluminescence immunoassay and immunohistochemical analysis were employed to detect the level of coagulation indicators and pyroptosis markers in serum and pancreas tissues. Additionally, we evaluated the effect of pyroptosis inhibition and NLRC4 silence on the function of human umbilical vein endothelial cells (HUVECs).
RESULTS: Coagulation disorders were significantly positively correlated to the severity of AP, and they could be a predictor for AP severity. Further analyses indicated that six genes-DOCK9, GATA3, FCER1G, NLRC4, C1QB and C1QC-may be involved in coagulation disorders of AP. Among them, NLRC4 was positively related to pyroptosis that had a positive association with most coagulation-related signatures. Data from patients showed that NLRC4 and other pyroptosis markers, including IL-1β, IL-18, caspase1 and GSDMD, were significant correlation to AP severity. In addition, NLRC4 was positively associated with coagulation indicators in AP patients. Data from mice showed that NLRC4 was increased in the pancreas tissues of SAP mice. Treatment with a pyroptosis inhibitor effectively alleviated SAP and coagulation disorders in mice. Finally, inhibiting pyroptosis or silencing NLRC4 could relieve endothelial dysfunction in HUVECs.
CONCLUSIONS: NLRC4-mediated pyroptosis damages the function of endothelial cells and thereby exacerbates coagulation disorders of AP. Inhibiting pyroptosis could improve coagulation function and alleviate AP.
Central sarcopenia is associated with the prognosis of various orthopedic surgeries in the elderly. This study aims to investigate its impact on the outcomes of single-segment lumbar fusion surgery in elderly patients. Retrospective analysis was conducted on 314 patients aged 60 to 80 who underwent single-segment posterior lumbar fusion surgery due to degenerative lumbar diseases. Patients were categorized into high psoas and L4 vertebral index (PLVI) and low PLVI groups according to the MRI-measured PLVI for central sarcopenia. Basic patient data, surgery-related parameters, functional assessments at preoperative and postoperative 3, 6, and 12 months, and X-ray-based fusion status were compared. The basic data of the two groups showed no significant differences. Parameters including the operative segment, preoperative hemoglobin levels, surgical duration, and intraoperative blood loss exhibited no significant variances. However, notable differences were observed in postoperative initial hemoglobin levels, transfusion requirements, and length of hospital stay between the two groups. During the postoperative follow-ups at 3, 6, and 12 months, the VAS scores for lower back pain and ODI scores in the lower PLVI group were significantly higher compared to the high PLVI group. Additionally, the EuroQoL 5D scores were notably lower in the low PLVI group. There were no significant differences between the groups in terms of leg pain VAS scores at each time point and the fusion status at 12 months postoperatively. MRI-based central sarcopenia has a negative impact on the therapeutic effectiveness following single-segment lumbar fusion surgery in elderly patients.
INTRODUCTION: From 2008 and following the withdrawal of rosiglitazone, obligatory cardiovascular outcomes trials are performed for glucose lowering drugs introduced to the market to ensure their cardiovascular (CV) safety. Paradoxically, these studies have demonstrated CV safety but also shown additional cardio-reno-vascular protection of some therapeutic agents. Additionally, nonsteroidal mineralocorticoid receptor antagonists (ns-MRA) have emerged as novel drugs for cardio - and renoprotection in type 2 diabetes (T2D) and chronic kidney disease (CKD). In addition to atherosclerotic CV disease, heart failure (HF) and CKD are important clinical problems in T2D leading to poor quality of life and premature death as such cardio-reno-vascular protection is an important clinical issue.
AREAS COVERED: We provide new insights into pharmacotherapeutic cardio-reno-vascular protection in T2D based on the new glucose lowering drugs and ns-MRA. PUB MED/CINAHL/Web of Science/Scopus were searched (May 2024).
EXPERT OPINION: The conventional glucose lowering approach alone which was implemented for decades is now replaced by the use of disease modifying drugs which lower the rates of CV events, HF decompensation, hospitalization due to HF, slow progression of CKD and all-cause mortality. Indeed, the choice of medications in T2D should be focused on underlying co-morbidities with cardio-reno-vascular protection rather than a gluco-centric approach.
The control population will include 20 adult volunteers (age 18-65 years) who meet the in the American Society of Anesthesiologists (ASA) Physical Status (PS) Classes 1 criteria. Exclusion criteria will be refusal, volunteers on any medication or significant history of bleeding.
Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer's disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused by the aggregation and peripheral deposition of the acute-phase reactant serum amyloid A (SAA) in chronic inflammatory conditions. Using super-resolution microscopy, we found that ASC colocalized tightly with SAA in human AA amyloidosis. Recombinant ASC specks accelerated SAA fibril formation and mass spectrometry after limited proteolysis showed that ASC interacts with SAA via its pyrin domain (PYD). In a murine model of inflammatory AA amyloidosis, splenic amyloid load was conspicuously decreased in Pycard-/- mice which lack ASC. Treatment with anti-ASCPYD antibodies decreased amyloid loads in wild-type mice suffering from AA amyloidosis. The prevalence of natural anti-ASC IgG (-logEC50 ≥ 2) in 19,334 hospital patients was <0.01%, suggesting that anti-ASC antibody treatment modalities would not be confounded by natural autoimmunity. These findings expand the role played by ASC and IL-1 independent inflammasome employments to extraneural proteinopathies and suggest that anti-ASC immunotherapy may contribute to resolving such diseases.
A high-fat diet (HFD) is a major risk factor for cardiovascular disease. However, the specific effects of a HFD on vascular inflammation and the protective role of vitexin, a bioactive compound derived from food, require further research. This study investigated the protective effects of vitexin intervention against HFD-induced vascular inflammation and its underlying mechanism. The results demonstrated that vitexin intervention significantly reduced body weight, serum total cholesterol, and low-density lipoprotein cholesterol levels in HFD-fed mice. Vitexin also improved vascular pathological changes and the inflammatory status in the mice. Furthermore, vitexin intervention reduced serum TMAO levels in HFD-fed mice by altering the gut microbiota composition. The HFD significantly increased N6-methyladenosine (m6A) levels in aorta tissues, while vitexin intervention reversed this abnormal m6A level. Through metabolite affinity responsive target fluorescence quenching and molecular docking assays, it was found that vitexin could directly bind to fat mass and obesity-associated protein (FTO), potentially promoting m6A demethylation. The dose-response relationship between TMAO and inflammation/m6A was further validated in HUVEC cells and in vivo mouse experiments. Specifically, TMAO increased m6A levels and inflammation, while vitexin inhibited TMAO-mediated m6A modification, exhibiting anti-inflammatory effects. In conclusion, this study demonstrates the protective role of vitexin against HFD-induced vascular inflammation by inhibiting TMAO-mediated RNA m6A modification, laying the foundation for the development of functional foods.
<P>PROBLEM TO BE SOLVED: To generate useful text document summary with high accuracy by a text summarizer using a suitability measurement technology and a potential semantic factoring technology.  <P>SOLUTION: A conventional IR technology is applied in a particular method to carry out the creation of the summary. The measurement of the compatibility, selection of the sentence and the deletion of terms are successively repeated. In a substitute embodiment, a singular value decomposition method is applied to term versus-sentence matrixes so that all sentences from documents are projected to a singular vector space. The text summarizer selects the sentence having the maximum index value in the most significant singular value vector as a part of text summary.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Obesity continues to rise in prevalence and financial burden despite strong evidence linking it to an increased risk of developing several chronic diseases. Dopamine response and receptor density are shown to decrease under conditions of obesity. However, it is unclear if this could be a potential mechanism for treatment without drugs that have a potential for abuse. Therefore, the aim of this study was to investigate whether moderate-intensity exercise could reduce body weight gain and the associated decreases in dopamine signaling observed with high-fat diet-induced adiposity. We hypothesized that exercise would attenuate body weight gain and diet-induced inflammation in high-fat (HF)-fed mice, resulting in dopamine signaling (release and reuptake rate) comparable to sedentary, low-fat (LF)-fed counterparts. This hypothesis was tested using a mouse model of diet-induced obesity (DIO) and fast-scan cyclic voltammetry to measure evoked dopamine release and reuptake rates. Although the exercise protocol employed in this study was not sufficient to prevent significant body weight gain, there was an enhancement of dopamine signaling observed in female mice fed a HF diet that underwent treadmill running. Additionally, aerobic treadmill exercise enhanced the sensitivity to amphetamine (AMPH) in this same group of exercised, HF-fed females. The estrous cycle might influence the ability of exercise to enhance dopamine signaling in females, an effect not observed in male groups. Further research into females by estrous cycle phase, in addition to determining the optimal intensity and duration of aerobic exercise, are logical next steps.
There is no specific antidote to duloxetine, but if serotonin syndrome ensues, specific treatment (such as with cyproheptadine and/or temperature control) may be considered. In case of acute overdose, treatment should consist of those general measures employed in the management of overdose with any drug.

An adequate airway, oxygenation, and ventilation should be assured, and cardiac rhythm and vital signs should be monitored. Induction of emesis is not recommended. Gastric lavage with a large-bore orogastric tube with appropriate airway protection, if needed, may be indicated if performed soon after ingestion or in symptomatic patients.

Activated charcoal may be useful in limiting absorption of duloxetine from the gastrointestinal tract. Administration of activated charcoal has been shown to decrease AUC and Cmax by an average of one-third, although some subjects had a limited effect of activated charcoal. Due to the large volume of distribution of this drug, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be beneficial.

In managing overdose, the possibility of multiple drug involvement should be considered. A specific caution involves patients who are taking or have recently taken duloxetine delayed-release capsules and might ingest excessive quantities of a TCA. In such a case, decreased clearance of the parent tricyclic and/or its active metabolite may increase the possibility of clinically significant sequelae and extend the time needed for close medical observation [see Warnings and Precautions (5.4) and Drug Interactions (7)]. The physician should consider contacting a poison control center (1-800-222-1222 or www.poison.org) for additional information on the treatment of any overdose. Telephone numbers for certified poison control centers are listed in the Physicians' Desk Reference (PDR).
BACKGROUND: Pseudo-orthostatic tremor is a hyperkinetic movement disorder usually associated with other neurological comorbidities, mainly Parkinson's disease.
CASE REPORT: A 65-year-old male presented with unsteadiness and leg tremor while standing. Electrophysiological evaluation confirmed the presence of pseudo-orthostatic tremor. Blood test showed an undiagnosed Graves' disease. A complete remission of tremor was achieved with methimazole. Dopamine transporter scintigraphy showed a mild reduction of the striatal binding, bilaterally.
DISCUSSION: Graves' disease can be associated with pseudo-orthostatic tremor. Thyroid function should be assessed in patients complaining of unsteadiness. The causative role of hyperthyroidism in determining dopaminergic degeneration and uncovering subclinical parkinsonism warrants further investigations.
Carbohydrate suggestions based on standard MyPlate. 45-65% kcal intake from carbs.
SARS-CoV-2 causes tissue damage in the endothelium and epithelium, increased vascular permeability and increased plasma levels of IL-6, IL-2, IL-7, IL-10 causing interstitial fibrosis in the lung is considered. Considering these factors in pathogenesis, a picture with high mortality from acute respiratory failure to severe ARDS emerges in critically ill COVID-19 patients. However, despite numerous studies, an effective antiviral treatment has not yet been found in COVID-19 disease. The low level of evidence for the recommendations presented in the guidelines on both treatment and mechanical ventilation has brought supportive treatments to the agenda. Recently, many articles have been published on the potential effects of anti-inflammatory and antioxidant treatments such as high-dose vitamin C, vitamin D, zinc and ozone therapy. In particular, high-dose intravenous vitamin C treatment is inexpensive, easily accessible, and it reduces mortality in patients with sepsis and ARDS in studies, suggesting that it may be beneficial in COVID-19 disease. this is a retrospective cohort study. The main goal of the study; to compare patients who did not receive high-dose vitamin C treatment in the first period of the epidemic and those who received treatment in the next period. the investigator aimed to determine the effect of Vitamin C on short-term mortality and length of stay in intensive care in critically ill COVID-19 patients. All patients' data on age, gender, body mass index, comorbidities (diabetes mellitus, hypertension, coronary artery disease, chronic obstructive pulmonary disease, other), PaO2 / FiO2 ratios, SOFA scores, ferritin, C-Reactive Protein, procalcitonin, lactate, neutrophil and lymphocyte values will be collected by scanning the hospital information system.
FIELD: medicine. ^ SUBSTANCE: offered is subtilisin immobilised on a water-soluble pharmacologically acceptable polymer and produced of Bacillus licheniformis bacteria by deep fermentation. The immobilisation is enabled by exposing an aqueous solution containing subtilisin and the pharmacologically acceptable polymer to ionising radiation. The polymer is specified in a group: polyethylene oxide, polyvinylpyrrolidone, polyacrylimide, Pluronic, dextrane. Before the exposure, the reaction mixture is frozen to (-20) - (-140)C. ^ EFFECT: immobilised subtilisin exhibits anticoagulant and thrombolytic properties and has a less evident toxic effect. ^ 4 cl, 9 tbl, 3 ex