anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the study, 68 knee arthroplasty patients were randomly assigned to the study and control groups. The mobilization protocol was applied to the study group (34). The mobilization protocol starts on the day of the operation and is completed on the day of discharge. The patient is mobilized within the first 24 hours after surgery. Mobilization protocol includes six levels. Level 1: Repositioning should occur every two hours. Level 2: Range of motion (PROM) should occur at least three times a day. Level 3: The head of bed (HOB) \>30 degrees. Duration goal: 5-15 minutes. HOB 65≥ degrees with patient sit in the bed. Duration goal: 5-15 minutes. Progress to level 4. Level 4: HOB 65≥ degrees with legs in dependent position (recliner chair). Duration goal: 5-15 minutes. Progress to level 5. Level 5: Stand/pivot/step to chair. Sitting in chair. Duration goal: 5-15 minutes. Progress to level 6. Level 6: Patient is able to ambulate at least three times a day. No intervention was applied to the control group. The primary outcome of the study is the effect of mobilization protocol on the state anxiety level, pain, mobility and physical function of knee arthroplasty patients. The results collected before the mobilization protocol, postoperative first day, second day, the discharged day and the 3rd week after discharge.
The invention relates to the technical field of medicines. Aims to provide the application of the astragalus root nucleotide in the preparation of antithrombotic medicaments. The invention discloses an application of astragaloside in preparing antithrombotic medicaments. The astragaloside can obviously prolong the blood coagulation time of blood and effectively prevent the formation of thrombus. Pharmacological experiments show that the astragalus nucleotide has more reliable and effective prevention effect on thrombus than the astragaloside and the medicinal property of the astragalus nucleotide is obviously enhanced compared with the astragaloside. Meanwhile, the astragaloside is obtained by processing a natural compound astragaloside, the processing method is simple, the yield is high, the physicochemical property is stable, the storage condition is simple, the preparation is convenient, the astragaloside can be prepared into various dosage forms and is convenient to take, the astragaloside is developed as an antithrombotic drug, the application prospect is wide, and the astragaloside has great market potential and social value.
A couples-based intervention to support perinatal women who are experience symptoms of depression. We will adapt the WHO Problem Management Plus manual for this study. There are 5 sessions that deal with stress management, problem-solving, behavioral activation, and skills to strengthen social support. The final session will be modified to enhance couple communication skills. Because many of our participants will be dealing with food scarcity, we will develop a priori strategies to help couple brainstorm dealing with this issue.
Intervention 2 will consist of eight 60-minute sessions conducted by phone over eight weeks (1 session/week on average), scheduled at times convenient for participants (including evenings and weekends if necessary). The sessions will cover a variety of topics, including the definition of chronic pain, the physiological processes underlying chronic pain, common pain-related conditions such as sleep disturbance, and the effects of chronic pain.
The study is a multi-center randomized control study.The enrollment period is 3 months. Patients who is in 6-17 years of age will be randomized recruited into two groups: the App-based asthma action plan group and the written CCAAP group. Patients in App group will receive written CCAAP and mobile phone-based asthma self-management APP (Youran Respiratory) which includes an electronic asthma action plan, peak expiratory flow monitor system and Peak Expiratory Flow Meter. Patients in written CCAAP management group will write down the symptoms and PEF in asthma diary. The data of the number of asthma episodes, the improvement of FEV1 , the number of unscheduled medical visits, the score of children's quality of life, the questionnaire of asthma knowledge, ACT / C-ACT score, the absent days of parental work, the absent days of children study, and the cost of health economics will be collected regularly in a year with the interval of 3 months to assess the efficacy of CCAAP in asthma management. The study will recruit 400 cases for each group from ten children's hospitals. The study will be completed in a year.
Rehabilitation group will be provided multidisciplinary interventions online and individually by ExorLive app. The screening with self-scored questionnaires and physical tests will be performed before and after 8 weeks rehabilitation.
In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with ZETIA compared with the relevant control arm (placebo or statin alone). However, myopathy and rhabdomyolysis are known adverse reactions to statins and other lipid-lowering drugs. In clinical trials, the incidence of creatine phosphokinase (CPK) >10 × ULN was 0.2% for ZETIA vs 0.1% for placebo, and 0.1% for ZETIA co-administered with a statin vs 0.4% for statins alone. Risk for skeletal muscle toxicity increases with higher doses of statin, advanced age (>65), hypothyroidism, renal impairment, and depending on the statin used, concomitant use of other drugs.

In post-marketing experience with ZETIA, cases of myopathy and rhabdomyolysis have been reported. Most patients who developed rhabdomyolysis were taking a statin prior to initiating ZETIA. However, rhabdomyolysis has been reported with ZETIA monotherapy and with the addition of ZETIA to agents known to be associated with increased risk of rhabdomyolysis, such as fibrates. ZETIA and any statin or fibrate that the patient is taking concomitantly should be immediately discontinued if myopathy is diagnosed or suspected. The presence of muscle symptoms and a CPK level >10 × the ULN indicates myopathy.
Clear to opalescent, colorless to pale yellow or pale brown, and is supplied as a sterile, concentrated solution (1000mg/vial). GSK249320 is for IV use only.
Evidence suggests that the symptoms of obsessive-compulsive disorder (OCD) arise from dysfunction of both the serotonergic and dopaminergic neurotransmitter systems. These two neurotransmitter systems are presumed to play a key modulatory role at the limbic-motor interface of the fronto-subcortical circuitry. However, in vivo knowledge linking the serotonergic and dopaminergic systems to OCD and OCD-related disorders is limited. In the current protocol, we plan to use PET to image the serotonin transporter (SERT) within the new radioligand \[11C\]DASB, in order to delineate regional abnormalities in SERT binding in drug-naive or drug-free OCD patients in comparison to healthy volunteers. In addition, we plan to examine the relationship between the regional PET measures of SERT and clinical severity measures of OCD. The goal of the present study is, thus, to further our understanding of the role of the serotonergic system in the pathophysiology of OCD.
In Part A, 4 dosing cohorts will receive a single oral dose of LQT-1213. The highest dose of LQT-1213 to be administered is 1.67 mg/kg.
Patients should be informed that fesoterodine may produce angioedema, which could result in life-threatening airway obstruction. Patients should be advised to promptly discontinue fesoterodine therapy and seek immediate medical attention if they experience edema of the tongue or laryngopharynx, or difficult breathing.

Patients should be informed that Toviaz, like other antimuscarinic agents, may produce clinically significant adverse effects related to antimuscarinic pharmacological activity including constipation and urinary retention. Toviaz, like other antimuscarinics, may be associated with blurred vision, therefore, patients should be advised to exercise caution until the drug's effects on the patient have been determined. Heat prostration (due to decreased sweating) can occur when Toviaz, like other antimuscarinic drugs, is used in a hot environment.

Patients should also be informed that alcohol may enhance the drowsiness caused by Toviaz, like other anticholinergic agents. Patients should read the patient leaflet entitled "Patient Information TOVIAZ" before starting therapy with Toviaz.
Evidence-based treatments (EBTs) for depression are often not available to persons needing them; this is particularly true of psychotherapies. Even when available, EBTs are often poorly delivered at less-than-optimal quality. High direct and indirect costs also limit the availability of EBTs. Together these barriers contribute to suboptimal treatment of depression in the community. In a preliminary step toward addressing these quality shortcomings, the investigators propose to conduct a blended efficacy- effectiveness randomized controlled trial (RCT) of high fidelity, Internet-delivered cognitive behavioral therapy (CBT) for depression, extending our previous research to maximize treatment availability and quality as well as to reduce costs. Over a 36-month recruitment period, the investigators will enroll 1,800 adults seeking care for depression from 3 rural healthcare clinics, 3 safety net federally qualified healthcare centers (FQHCs), and 2 non-profit HMOs. Participants will be randomized to: (a) a treatment as usual (TAU) control condition, typically antidepressants and/or psychosocial services; (b) TAU plus Pure self-help Internet CBT for depression, consisting of access to the Internet site without any contact with therapists; (c) TAU plus Guided self-help Internet CBT, consisting of access to the Internet site plus brief, periodic telephone contacts with therapists; or (d) a Stepped-Care Internet CBT condition, starting with TAU + Pure self-help CBT and progressing to Guided self-help CBT if adequate progress is not observed early on. Participants will be followed for one year. The primary hypothesis for which the study is powered is that Guided self-help CBT will result in greater depression symptom improvement than Pure self-help CBT. The investigators also expect secondary analyses to reveal this pattern of results: Guided CBT \> Pure CBT \> TAU. The investigators will conduct cost-effectiveness analyses (CEA), as the investigators project substantial differences in the direct costs of each study arm. The investigators will also examine TAU healthcare utilization (medications, visits, etc) from electronic medical records (EMR), billing systems, and participant report. The investigators hypothesize that cost per depression free days (DFDs) and quality- adjusted life years (QALYs) will be lowest for Pure CBT, relative to Guided and Stepped-Care CBT and TAU. The investigators also hypothesize that cost per unit of improvement in QALYs and DFDs will be better for Stepped-Care compared to Guided CBT. Additional aims include exploratory examination of secondary outcomes, and predictors and moderators of outcomes among the interventions. The investigators also will collect quantitative and qualitative data on patient, provider, and organizational factors that may impede or facilitate implementation of these interventions, to help prepare for future dissemination efforts. Finally, in this reapplication the investigators have added a non-research Reach Estimation Phase to better estimate acceptance and retention rates under conditions that closely match real-world dissemination
Psoriasis is an autonomous inflammatory disease caused irrespective of ages and races. The disease is known to occur because the breakdown of a balance in skin bacteria makes external bacteria easily penetrate, but such a concept is still controversial. The study relates to a method for treating an imbalance in the skin of a psoriasis patient, and has been conducted to confirm the possibility of whether bacteria of normal skin can be used. Experiments are divided into three. Bacteria are extracted from skin of a psoriasis patient and a normal person, and the bacteria are classified according to features. Then, correlation between skin bacteria is observed. Skin bacteria are extracted by being divided into a psoriatic part and a normal part with respect to a psoriasis patient, and skin bacteria are extracted from a 5 cm position in the left of the navel with respect to normal person skin. The extracted bacteria are classified according to the features of colonies generated after being cultured in NA or MRS Agar. Total eight kinds of bacteria are selected, and a bacteria extract liquid is produced by culturing the same. Each of the bacteria is cultured by inoculating skin bacteria in a broth media including the bacteria extract liquid according to the combination thereof. In normal skin, a large quantity of bacteria grown in an MRS culture medium rather than general bacteria is discovered. However, in psoriasis skin, the quantity of general bacteria is larger, and thus an imbalance is shown in the bacterial flora of psoriasis patient skin. In a step of confirming an antibacterial effect, Dp and Gn discovered in normal skin are shown to inhibit the proliferation of bacteria growing in the psoriatic part of a psoriasis patient. Accordingly, the useful properties of the bacteria are expected to be able to be clinically used in treating an imbalance in psoriasis patient skin.
Participants will receive a single dose of 300 mg inclisiran administered by SC injection on Day 1. Mild renal impairment is defined as CrCl ranging from 60 to 89 mL/min.
Previous studies have shown that isometric strengthening is beneficial in managing osteoarthritis of the knee. This type of exercise can decrease joint-related pain and stiffness while increasing strength and functional measures. However, individuals rarely adhere to isometric exercise for any lengthy period of time because there has not been a way to measure applied force and performance over time in the home setting. In addition, this type of exercise has often been described as "boring." We believe that being able to monitor one's progress is essential in maintaining adherence to an isometric exercise program. This study will examine the effectiveness of a portable isometric exercise device for home use that guides the user through an exercise protocol by means of various forms of feedback.

We hypothesize that individuals exercising with the device will achieve better outcomes in pain, stiffness, strength, and functional measures than a control group or a group exercising according to printed material from arthritis advocacy groups. We will randomly assign study participants meeting eligibility criteria to the exercise device group, exercise according to printed material group, or control group. We will conduct measures in all groups during a clinic visit at baseline, 2, 4, 6, and 8 weeks. As subjects in the exercise device group strengthen their leg muscles, a physical therapist will likely need to adjust upward the target force for different leg positions during every clinic visit, 2 weeks apart.
PURPOSE: To highly efficiently dry a granular article contg. a component tending to autolysis by heat and to uniformly mix a water-soluble component contained in the granular article in the article. CONSTITUTION: Crushed sodium bicarbonate is humidified and kneaded with a water-soluble component, and the kneaded material is granulated and then dried to obtain a granular article. In the drying stage, the granular article is rotated, and dry air is supplied from the lower part. A perforated plate 16 is eccentrically rotated, hot air is supplied through a hole 15a from below (in direction of the arrow B, hence the granular material in a drying shelf 201 is rotated in direction of the arrow A, moved and transferred to a lower-stage drying shelf 202 from a discharge port 17. The water-soluble component in the sodium bicarbonate is uniformly distributed in the sodium bicarbonate while being rotated and heated.
FIELD: pharmaceuticology for different purposes. SUBSTANCE: aerosol packages contain biologically pure substances, working medium, stabilizing agent and/or lubricant for the valve. They contain polyoxyethylene- glycerin - oleates as suspension stabilizing agents and/or lubricant for the valve. TG 227 and/or TG 134 is used as working medium in production of aerosol packages under pressure. EFFECT: improved quality. 9 cl
Current application rates suggest that more than half of Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans will eventually apply for some form of service-connection, with approximately 100,000 Veterans per year being evaluated for psychiatric conditions. Veterans applying for service-connection for psychiatric conditions are in distress, and often are having occupational difficulties, but these are unaddressed during a typical Compensation and Pension evaluation. Counseling that addresses beneficiaries' concerns about losing compensation payments if working for pay, when supplemented by vocational supports, has been associated with increased employment among people disabled by chronic psychiatric conditions. This group has developed an online Benefits Counseling intervention tailored to help Veterans applying for service-connection engage in work-related activities. The investigators have demonstrated the efficacy of a face-to-face version of Benefits Counseling in a completed Rehabilitation Research \& Development-funded six-month clinical trial in which Veterans assigned to Benefits Counseling worked significantly more days than controls,(p\<.05, effect size = 0.69), reflecting an average of three more days of employment at six month follow-up. The investigators then used a supplement from Rehabilitation Research \& Development to develop a web-based version of this counseling, so that the counseling could be delivered without a counselor on-site. The web-based intervention was modified based on user feedback, but the extent to which it will be used by Veterans at home and how it will impact their behavior is unknown. In the proposed clinical trial, Veterans working two or fewer days per week who are presenting for a Compensation \& Pension examination for a psychiatric disorder will be assessed at baseline and then urged to log in afterwards to a website for random assignment to either Remotely-Delivered Benefits Counseling (n=65) or Veterans Benefits Administration web sites (n=65), and will then be assessed at 4, 12, and 24 weeks after randomization in order to calculate standardized group mean differences between the slopes over time. The primary outcome measure will be the treatment-by-time slope of hours of paid work. Exploratory analyses will estimate associations of potential mediators of treatment response with this outcome. The proposed study will provide estimates of the efficacy of remotely-delivered Benefits Counseling initiated at Compensation and Pension examinations, a widely-used point of contact with VA.
PURPOSE:To impart the resistances to acid, heat, salt, alkali, enzyme and freezing to food etc. and to cause thickening and gelation of the same in a small amount of use, by adding both a jellan gum and a saccharide derived from the seed of a tamarind to the same. CONSTITUTION:Both of a jellan gum and a saccharide derived from the seed of a tamarind are added to food etc. to cause thickening and gelation of the same. A solution of the saccharide alone has a very low viscosity, and so is a solution of the jellan gum alone. However, when the saccharide is used in combination with the jellan gum and they are heated and dissolved in each other, a solution having a very high viscosity can be obtd. An increase in the amount of use of the combination brings about gelation. When the aforesaid combination is used together with 0.01-0.5% other high-molecular polysaccharides, e.g., locust bean gum or carageenan, the thickening property is enhanced, so that a flexible gelation product can be prepd.
Evaluation of textual annotation models is provided. In various embodiments, an annotation model is applied to textual training data to derive a plurality of automatic annotations. The plurality of automatic annotations is compared to ground truth annotations of the textual data to determine overlapping tokens between the plurality of automatic annotations and the ground truth annotations. Weights are assigned to the overlapping tokens. Based on the weights of the overlapping tokens, scores are determined for the automatic annotations. The scores indicate the correctness of the automatic annotations relative to the ground truth annotations. Based on the scores of for the automatic annotations, an accuracy of the annotation model is determined.
Void-containing microcapsules are prepared by a method featuring gellation of an organic polymer with the simultaneous precipitation of an organic liquid non-solvent. The method involves the preparation of a solution containing an organic polymer, a good solvent for the polymer and an organic liquid non-solvent which is miscible with the polymer solvent. The solution is then atomized into a bath containing a liquid which is miscible with the good polymer solvent but which is immiscible with the organic liquid non-solvent. The bath liquid extracts out the good polymer solvent, causing gellation of polymer around discrete droplets of the organic liquid non-solvent, which simultaneously precipitates out of the solution as the good polymer solvent is extracted, thereby producing microcapsules having encapsulated therein the non-solvent. The organic liquid non-solvent can then be removed as by evaporation to provide void-containing microcapsules. These void-containing microcapsules may be employed as opacifying agents. In addition to producing void-containing microcapsules, this method can be utilized to produce microcapsules in which pigments are entrapped in the voids or the polymeric walls of the microcapsules or in which certain non-solvents which serve a secondary function remain entrapped in the microcapsules. Such non-solvents include, for instance, vitamins, minerals, biocides, perfumes, chemical reactants, fertilizers, and the like.
Living patients or their healthcare surrogates will provide informed consent prior to participation in the biorepository. Surrogate decision makers who cannot consent in person will be consented in accordance to the KUMC remote consent guidelines. Biospecimens to be collected include serum, plasma and whole blood. Blood samples will be collected during face-to-face encounters in the Post-COVID-19 clinic within the TUKHS pulmonary clinic or will be coordinated with other outpatient follow-up appointments (including separate procedure/lab-related visits) or separate study visits for ongoing, indepent studies. Samples will be collected at time of consent as well as at potential follow-up visits at approximately 3, 6, 12, and 12 months from enrollment. Blood samples will be processed, aliquoted, and stored at -80°C. A portion of the blood samples will be kept for DNA and RNA isolation, and a portion of plasma collected might be utilized to isolate peripheral blood mononuclear cells. Biospecimens will be labeled with the patient's study ID number, date of sample processing, and specimen type. Biospecimens will be stored through the duration of the study. If the patient chooses to withdraw consent, his or her samples in the biorepository will be destroyed. Biospecimens that have been previously used or disseminated will continue to be utilized. Future research may include whole genome testing, and these results will not be shared with the patient or their standard of care physician.

Patient data and historical radiographic imaging from after the date of consent will be collected using TUKHS medical records and stored in RedCap. The data to be collected is outlined in the data collection sheets.