anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sepsis and septic shock are frequent and severe clinical pictures in intensive care medicine that result from a dysregulated immune response to an infection and cause a high mortality rate. This article provides an overview of the various extracorporeal procedures used to treat sepsis. Various procedures are used to treat sepsis and septic shock. These include high-volume hemofiltration (HVHF), very high-volume hemofiltration (VHVHF), high cut-off filter (HCO), polymyxin B hemoperfusion and cytokine adsorption filters. The HVHF and VHVHF remove inflammatory mediators but show no significant benefit in terms of stabilization and survival in sepsis patients. The HCO filters effectively eliminate cytokines but so far there is no evidence of a survival benefit. Polymyxin B hemoperfusion shows promising results in initial studies in certain patient groups, while evidence for cytokine adsorption filters is limited. Combined plasma filtration and adsorption (CPFA) and therapeutic plasma exchange (TPE) have so far shown promising results in small studies. Although CPFA shows no survival benefit, TPE may have protective effects on the vascular glycocalyx. Extracorporeal procedures carry risks such as thrombosis and loss of proteins and clotting factors. The therapeutic benefit of these procedures in the treatment of sepsis remains unclear and further prospective randomized multicenter studies are needed to evaluate their efficacy and safety. There are currently no guideline recommendations for the routine use of these procedures in sepsis.
Risk Summary

Available data from a lactation study in 8 women indicates that lemborexant is transferred into the breastmilk of nursing mothers, and the results have established a mean daily infant dose of 0.0029 mg/kg/day and a relative infant dose of less than 2% of the maternal dose. These data support that transfer of lemborexant into breastmilk is low (see Data). There are no data on the effects of lemborexant on the breastfed infant, or the effects on milk production. Infants exposed to DAYVIGO through breastmilk should be monitored for excessive sedation. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for DAYVIGO and any potential adverse effects on the breastfed infant from DAYVIGO or from the underlying maternal condition.

Data

A single dose milk-only lactation study was conducted in 8 healthy adult lactating women. The mean amount of lemborexant recovered in human milk was 0.0174 mg following a 10 mg maternal dose. The mean calculated daily infant oral dosage was 0.0029 mg/kg/day based on nominal infant body weight of 6 kg. Approximately 70% of the total amount of lemborexant excreted in milk was excreted by 24 hours after a single maternal dose administration. There are no data on the effects of lemborexant on the breastfed infant, the effects on milk production, or infant exposure after repeated maternal dosing of lemborexant.
Most physicians do not adopt a strategy of complete suction of fluid from the intestinal lumen during colonoscopy. There are both concerns about the time required for colonoscopy and the possibility of inability to thorough cleannig up. Some endoscopists believe that the visual field for partial cleaning of fecal water is acceptable and does not affect observation. This study aims to make an observation and comparison based on the existing problems mentioned above. With the help of direct water injection system, the investigators plan to adopt a thorough flushing strategy when withdrawing the endoscope, and have zero tolerance for the liquid and foam in the intestinal lumen. Observe and compare the impact of this strategy with traditional limited degree suction methods on the results of colonoscopy. The research group and the control group respectively adopted a thorough flushing strategy and a limited flushing strategy, and compared the total time of colonoscopy examination, the time of withdrawal, the detection rate of polyps, the detection rate of small polyps, and the amount of flushing fluid between the two groups. Analyze the value of thorough flushing strategy for the efficiency and quality of colonoscopy examination.
Participants allocated to this group will receive the interactive e-book of EducaDor program in their smartphone devices and e-mail, in addition to usual care. Before receiving the e-book, the users will also participate in an individual or group synchronous meeting of up to 12 participants on the Whereby® platform to receive a guidance for the use of interactive e-book over the 10 weeks.
<P>PROBLEM TO BE SOLVED: To provide a polyphenol having little side effects and excellent action of fibroblast activation and to provide an excellent food supplement and an excellent cosmetic each containing a polyphenol and having little side effects.  <P>SOLUTION: The polyphenol having action of fibroblast activation contains an epigallocatechin derivative. The derivative is composed of a parent nucleus of a polyphenol and any one of teaflavin, ellagic acid, betaine, ascorbic acid, dehydrokraepellic acid, 6-oxooctadecanoic acid, γ-linolenic acid, linoleic acid, oleic acid, palmitic acid, and stearic acid and bonded through an ester linkage to position 3 of ring A of the parent nucleus. A polyphenol is also provided which is obtained by adding cellulase to a pulverized plant material and extracting the product with liquefied carbon dioxide or hexane. The food supplement and the cosmetic each contains the polyphenol having action of fibroblast activation.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Bipolar II disorder (BDII) is a serious condition characterized by depressive and hypomanic episodes. The disability and suicide risk associated with BDII is equal to bipolar I disorder. However, there are no clinical trials for BDII, nor is the treatment of BDII addressed in current treatment guidelines. Data suggest that Li and LTG may be effective treatment options for BDII. This study will determine the safety, effectiveness, and tolerability of the two drugs in people with BDII.

Participants in this study will be randomly assigned to receive either Li or LTG for 16 weeks. Participants will be assessed every 2 weeks. One week after study completion, participants will have a follow-up visit. Measures of depression, mania, quality of life, functioning, and participant satisfaction will be taken.
BACKGROUND: Fusarium circinatum is the causal agent of pine pitch canker disease, which affects Pinus species worldwide, causing significant economic and ecological losses. In Spain, two Pinus species are most affected by the pathogen; Pinus radiata is highly susceptible, while Pinus pinaster has shown moderate resistance. In F. circinatum-Pinus interactions, phytohormones are known to play a crucial role in plant defense. By comparing species with different degrees of susceptibility, we aimed to elucidate the fundamental mechanisms underlying resistance to the pathogen. For this purpose, we used an integrative approach by combining gene expression and metabolomic phytohormone analyses at 5 and 10 days post inoculation.
RESULTS: Gene expression and metabolite phytohormone contents suggested that the moderate resistance of P. pinaster to F. circinatum is determined by the induction of phytohormone signaling and hormone rearrangement beginning at 5 dpi, when symptoms are still not visible. Jasmonic acid was the hormone that showed the greatest increase by 5 dpi, together with the active gibberellic acid 4 and the cytokinin dehydrozeatin; there was also an increase in abscisic acid and salicylic acid by 10 dpi. In contrast, P. radiata hormonal changes were delayed until 10 dpi, when symptoms were already visible; however, this increase was not as high as that in P. pinaster. Indeed, in P. radiata, no differences in jasmonic acid or salicylic acid production were found. Gene expression analysis supported the hormonal data, since the activation of genes related to phytohormone synthesis was observed earlier in P. pinaster than in the susceptible P. radiata.
CONCLUSIONS: We determine that the moderate resistance of P. pinaster to F. circinatum is in part a result of early and strong activation of plant phytohormone-based defense responses before symptoms become visible. We suggest that jasmonic acid signaling and production are strongly associated with F. circinatum resistance. In contrast, P. radiata susceptibility was attributed to a delayed response to the fungus at the moment when symptoms were visible. Our results contribute to a better understanding of the phytohormone-based defense mechanism involved in the Pinus-F. circinatum interactions and provide insight into the development of new strategies for disease mitigation.
Trained facilitators and coaches will deliver the programme over eight weekly sessions at the Udon Thani Regional Hospital during the feasibility pilot and the RCT. During the RCT, the 60 parents/primary caregivers in the intervention group will be divided into 4 groups of 15 participants, with each group overseen by 2 facilitators and 1 coach. Core session activities may include discussion about assigned home activities, core parenting principles, illustrated stories, role-plays, and problem solving. Home visits will be conducted by facilitators to those parents/primary caregivers who miss sessions or require additional support, and SMS/LINE messages will be delivered to all participants twice per week with relevant parenting tips and reminders to attend the upcoming session.
In this study we will be administering from 1 x 10\^6 to 1 x 10\^9 transduced autologous VZV-specific CTLs, derived from VZV-specific memory T cells, so there will be no risk of alloreactivity. 6.1.1 Pre-infusion lymphodepletion for dose levels 9-11: Patients will receive 3 daily doses of cyclophosphamide together with fludarabine to induce lymphopenia, finishing at least 24 hours before T cell infusion. Cyclophosphamide will be given at a dose of 500 mg/m2/day followed by Fludarabine 30 mg/m2/day.
INTRODUCTION: Heart failure (HF) is associated with significant morbidity, mortality, and health care costs. Stage B HF is defined as structural heart disease prior to developing symptomatic HF. If identified early in the disease process, preventative measures may be implemented to slow disease progression to Stage C (symptomatic) or Stage D (refractory) HF. Previous research has focused on outpatient screening for HF in the primary care setting; however, there are limited data on Stage B HF screening in the Emergency Department (ED) setting. The objective of this study was to determine the prevalence of undiagnosed Stage B HF among those with cardiovascular risk factors in the ED setting and identify which risk factors were associated with a greater risk of having Stage B HF.
METHODS: A prospective, observational study was performed in a single, urban academic ED from 07/2023 to 05/2024. Inclusion criteria were age ≥ 45 years with hypertension, diabetes, obesity, coronary heart disease, previous cardiotoxic chemotherapy, or family history of HF. Exclusion criteria included signs or symptoms of HF, known history of HF, valvular disease, current atrial fibrillation, or primary language other than English. A focused cardiac ultrasound was performed and interpreted by ultrasound-fellowship trained emergency physicians. Sonographers assessed systolic function as ejection fraction <50 % using visual assessment in at least two different views. Sonographers assessed diastolic dysfunction as an E/A ratio < 0.8, or if ≥2 of the following were present: septal e' < 7 cm/s or lateral e' < 10 cm/s, E/e' ratio > 14, or left atrial volume > 34 mL/m2. Descriptive statistics were performed, followed by comparative analyses and regression modeling.
RESULTS: 209 participants were included in the study, with a mean age of 60 years and 51.7 % women. Of these, 125 (59.8 %) had undiagnosed Stage B HF, with 13 (10.4 %) having systolic dysfunction and 112 (89.6 %) having isolated diastolic dysfunction. Among those with isolated diastolic dysfunction, 44 (39.3 %) were grade I, 66 (58.9 %) were grade II, and 2 (1.8 %) were grade III. Predictors of undiagnosed Stage B HF included age (odds ratio 1.06; 95 % CI 1.02 to 1.10) and BMI (odds ratio 1.06; 95 % CI 1.01 to 1.10).
CONCLUSION: A large majority of ED patients with cardiovascular risk factors had undiagnosed Stage B HF. Age and obesity were associated with a higher risk of Stage B HF. This provides an opportunity for early identification and intervention for patients with undiagnosed Stage B HF to reduce progression to more severe HF.
The present invention relates to wrinkle eliminating cream and a preparation method thereof. All the raw materials are natural raw materials of food. The main ingredients comprise starch, milk powder, honey, white sugar, rapeseed and edible essence and white spirit. The wrinkle eliminating cream is prepared through proportioning, grinding, fermenting and regrinding the raw materials. The wrinkle eliminating cream has abundant nutrition and no side effect. The wrinkle eliminating cream can rapidly eliminate deep wrinkles on the whole face and wrinkles at the canthus. When used for an emaciation child's face with sallow complexion, the wrinkle eliminating cream also has a certain effect.
Patients will exercise three times per week for 6 months home-based exercise intervention. Session duration will vary between 20 minutes and 45 minutes.
BA is an evidence-based psychotherapy with more than 25 randomized trials showing effectiveness in depression. The therapy group will consist of an introductory in person 50-minute treatment session, followed by 12 weekly telephone 50-minute outpatient treatment sessions, then 3 monthly telephone 50-minute outpatient maintenance sessions. A typical BA session will last 50 minutes and include a review of the previous session and completed daily monitoring record forms, an in-depth discussion of life areas and value, and verbal reinforcement of activity engagement.
A randomized controlled clinical trial, a double-blind (patient and examiner) is conducted by one trained and calibrated operators who perform all restorative procedures. The restorations will be evaluated by a blind and calibrated two examiner using the FDI (World Dental Federation) criteria. A total of 25 subject will be randomly assigned to each group for a total of 50 subject. The randomization sequence will be generated (www.randomlists.com/team-generator) and to ensure the confidentiality of the allocation, this will be used opaque, sealed and numbered envelopes in series. These will be kept with an independent researcher for the moment of inclusion of the subjects.

Both groups will receive Inlay/Onlay preparation . Digital impression will be taken, wax pattern for the Inlay/Onlay restoration will be designed and milled using CAD/CAM(computer-aided design/computer-aided manufacturing) software. After that, the wax pattern will be invested and final Inlay/Onlay restoration will be constructed from VITA AMBRIA and IPS e.max press ingots according to manufacturing instructions.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely, to proctology, and is intended for low-invasive treatment of complete complex pararectal fistulas. Sinus tract is examined, its direction and presence of external and internal holes are determined. Successively, each sinus tract is treated through external hole, with obturation of external hole of untreated sinus tract, as minimum two times, with two-day interval. Treatment is carried out during 40-80 seconds by ultrasonic fluctuations with frequency 20-60 kHz with simultaneous supply of liquid phase. As liquid phase, used is alcohol solution in amount 10-20 ml, depending on sinus tract dimensions, which is supplied at rate 0.25 ml per second. As alcohol solution used is three percent alcohol iodine solution or seventy percent ethyl alcohol. ^ EFFECT: method is low-invasive, makes it possible to eliminate injury of anatomical structures of anal canal, reduce treatment cost, can be carried out on outpatient basis. ^ 2 ex, 2 dwg
Subjects will be asked to fast overnight. Upon presentation, FibroScan procedure with CAP will be conducted and baseline and postprandial bile acid profile will be assessed. Then, intravenous morphine will be administered and the pharmacokinetic profile will be assessed over 8 hours.
The proposed project will be an observational, case-series study. The investigators anticipate enrolling 40 study subjects. Treatment Procedures: Following initial treatment planning discussions between the dentists and their patients regarding all of their dental treatment options, those patients who opt to have dental implants placed will be approached to discuss participation in the current study. Before entry into the study, the Investigator or an authorized member of the investigational staff will explain to potential subjects the aims, methods, reasonable anticipated benefits, and potential hazards of the study, and any discomfort it may entail. Subjects will be informed that their participation is voluntary and that they may withdraw consent to participate at any time. They will be informed that choosing not to participate will not affect the care the subject will receive for the treatment of their condition. Subjects will be told that alternative treatments are available and that if they decline to take part in the present study that such a refusal will not prejudice future treatment. Those patients who are willing to participate will be scheduled for their initial and follow-up dental implant visits at the School of Dentistry. At the baseline visit the study outcome data will be collected; including: 1) measuring the bone-ridge width, before and after implant site preparation (drilling); 2) intraoral photographs of the prepared opening; 3) dental implant torque readings will be obtained; and 4) ISQ as measure of both initial and the dynamic development of osseointegration (the formation of a direct interface between the dental implant and bone) over time. The ISQ measurements will be collected again at three and six-weeks post treatment.
Plyometric training is an exercise method that has gained significant popularity in recent years for effectively enhancing explosive power in the lower limbs. It involves rapid and forceful muscle contractions following a quick stretch. This type of training enables the body to generate maximum muscle strength for short durations during exercise. As individuals age, their ability to produce explosive power decreases, particularly in the lower limbs. This decline in explosive power can result in reduced responsiveness to sudden balance disturbances, leading to falls among the elderly and greatly impacting their daily activities. Hence, the objective of this study was to investigate the effects of a 10-week plyometric training program on the balance ability of the lower limbs in elderly individuals.

A total of 38 elderly participants, aged between 65 and 89 years, were randomly assigned to either the experimental group (N=19) or the control group (N=19). The experimental group underwent plyometric training three times a week, performing three rounds each session, for a total intervention period of 10 weeks. The control group, on the other hand, engaged in regular exercises during the same intervention period. Before and after the training program, both groups underwent assessments to evaluate their balance abilities, which included the 30-second sit-to-stand test, time up and go test (TUG), functional reach test (FRT), and lower extremity explosiveness test. To analyze the data, SPSS 18.0 statistical software was used. Independent sample t-tests were employed to compare the baseline values between the two groups and to determine the differences in the 30-second sit-to-stand test, TUG, FRT, and force plate maximum reaction force values after the intervention. Paired samples t-tests were conducted to assess changes in balance performance from pre-test to post-test. The statistical significance level (α) was set at 0.05.
PURPOSE: To obtain a skin cosmetic excellent in skin chapping-remedying effect by formulation of a pH-stabilized α-hydroxyacid aqueous solution prepared by adding a base to an α-hydroxyacid aqueous solution followed by heat treatment. CONSTITUTION: Firstly, a base (e.g. NaOH) is added to an α-hydroxyacid aqueous solution (e.g. an aqueous solution of glycolic acid) to adjust the solution to pH8-9 followed by heat treatment of the solution at 8-90 deg.C for one hour or longer to prepare a pH-stabilized α-hydroxyacid aqueous solution with pH5.5-6.5. The objective skin cosmetic having skin wrinkle-remedying effect can be obtained by formulating a skin cosmetic with this pH-stabilized a hydroxyacid aqueous solution. Besides, formulation of a hyaluronic acid (salt) in the above cosmetic improves the humectancy of the objective skin cosmetic; and formulation of the culture supernatant for lactic acid bacteria in the above skin cosmetic improves wrinkle-proofing effect, humectancy, and use feeling of the objective cosmetic.
The content of the approximately 20 minutes video is recorded in advance of the intervention by a certified teacher with teaching experience. The 20 minutes session consists of a series of body stretching exercises (around 17 different gentle and simple stretches from head to toe) with the incorporation of breathing technique (i.e. when to breathe in and breathe out). The whole body stretching exercise is performed with a sitting position, ideally on an exercise mat. As mentioned above, the participants are required to conduct the stretching exercise by following the guidance video for at least 5 days weekly for at least 2 weeks duration. The video will be uploaded onto a webpage which requires participants to log in and view the video. The webpage and video will be accessible through computers and mobile phones.
PURPOSE:To obtain the subject suppressive agent, containing a specific delta-opioid antagonist as an active ingredient with low toxicity and capable of exhibiting excellent immunosuppressive activity by oral administration. CONSTITUTION:The objective suppressive agent containing a delta-opioid antagonist expressed by formula I (R1 is 1-5C alkyl, 3-6C cycloalkylalkyl, etc.; R2 is H, hydroxy or 1-5C alkanoyloxy; R3 is H, 1-5C alkyl, etc.; X is O, S or N to which Y is bound; Y is H, 1-5C alkyl, etc.; R4 and R5 are H, F, Cl, Br, etc.) or a pharmacologically acceptable salt thereof as an active ingredient. Furthermore, naltreoxone is preferably allowed to react with a phenylhydrazine derivative in the presence of methanesulfonic acid in a solvent to afford an naltrindole derivative expressed by formula II (R7 is H, Cl, etc.).
Group of up to 50 patients will randomly allocated into an experimental group at a 4:1 ratio intervention to controls. The experimental group will receive all of the preliminary outcome measure testing (cardiovascular, musculoskeletal, and psychological screening) in addition to exercise intervention education, demonstration, and follow up to ensure compliance and safety.