anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The main objective of this study is to assess the level of motivation towards physical activity and psychosocial outcomes (i.e., internalizing and externalizing behavioral symptoms, self-concept and academic achievement as assessed through recent grade) among young adolescents and to develop intervention to enhance motivation towards physical activity among young adolescents. Randomized Control Trial design will be used in this study to examine the impact of school-based intervention on motivation towards physical activity and psychosocial outcomes. After assessing their motivation toward physical activity and psychosocial outcomes intervention will given for 10 weeks, in which participants will be asked to participate in 10 minutes exercise activity on regular basis from Monday to Friday during school timings. Assessment will be done to find out that whether the school based intervention will be effective for them in motivation towards physical activity and reduction psychosocial outcomes (i.e., internalizing and externalizing behavioral symptoms, self-concept and academic achievement (as assessed through recent grade)) among adolescents or not. This results of this study will be used in promoting active lifestyle may help the adolescent to develop long-term positive healthy habits and targeting adolescents through encouraging physical activity in school or educational setting and social surrounding. To make decision about effective programs and policies to promote physical activity should be taken in account, by providing empirical support for public health messages that encourage participation in school spots as a mean to reduce the burden of poor mental health. Physical activity programming must align with the predictable developmental changes in adolescent exercise capacity and motor skills, which affect the activities in which they can successfully engage. These programs specifically designed to improve psychosocial outcomes, such as self-concept, social behavior and self-efficacy of adolescents as these are the most important determinants of participation in physical activities.
AIMS: Increasing numbers of overweight and obese patients undergo pulmonary vein isolation (PVI), despite the association between higher body mass index (BMI) and adverse PVI outcomes. Evidence on complications and quality of life in different bodyweight groups is limited. This study aims to clarify the impact of BMI on repeat ablations, periprocedural complications, and changes in quality of life.
METHODS AND RESULTS: This multi-centre study analysed prospectively collected data from 15 ablation centres, covering all first-time PVI patients in the Netherlands from 2015 to 2021. Patients were categorized by BMI: normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obesity (≥30 kg/m2). Quality of life was assessed using the Atrial Fibrillation Effect on QualiTy-of-life questionnaire at baseline and 1-year post-PVI. Among 20 725 patients, 30% were of normal weight, 47% overweight, and 23% obese. Within the first year after PVI, obese patients had a higher incidence of repeat ablations than normal-weighing and overweight patients (17.8 vs. 15.6 and 16.1%, P < 0.05). Obesity was independently associated with repeat ablations (odds ratio 1.15; 95% confidence interval 1.01-1.31, P = 0.03). This association remained apparent after 3 years. Complication rates were 3.8% in normal weight, 3.0% in overweight, and 4.6% in obese, with weight class not being an independent predictor. Quality of life improved in all weight groups post-PVI but remained lowest in obese patients.
CONCLUSION: Obesity is independently associated with a higher rate of repeat ablations. Pulmonary vein isolation is equally safe in all weight classes. Despite lower quality of life among obese individuals, substantial improvements occur for all weight groups after PVI.
PURPOSE:To shorten a wait time by providing a medical computer installed in a medical institution and computers for pharmacies which are installed in the pharmacies and connected to the medical computer, and receiving prescription data at the computers for the pharmacies from the medical computer and issuing temporary prescriptions according to the received data. CONSTITUTION:The medical computer 1 which is installed in the hospital and the computers 2 which are installed in the pharmacies A and B are connected through a telephone line 4. After a patient is consulted and treated, header data and consulting data are inputted to the medical computer 1 and stored in a header file 12 and a consulting file 13. A processing part 6 transfers the header data on the patient and the prescription data in the consulting data to a transmitting buffer 9, from which the data are sent. One pharmacy computer receives the prescription data and issues a temporary prescription according to the data. Consequently, when the patient visits the pharmacy with the prescription, the patient can receive prepared medicines immediately or in a slight wait time.
The invention discloses a biflavone-zinc complex as well as a preparation method therefor and a use thereof. The invention takes amentoflavone as a ligand, zinc ion as a central ion, and amentoflavone-zinc complex is obtained through reaction. The structure of the complex is characterized with infrared spectrometry, ultraviolet-visible absorption spectrometry and high-resolution mass spectrometry. Meanwhile, the invention studied the anti-tumor activity and the anti-oxidation activity of the amentoflavone-zinc complex. An MTT assay proves that the amentoflavone-zinc complex has better anti-tumor activity which is superior to that of amentoflavone; a pyrogallol auto-oxidation method and an ABTS method prove that the anti-oxidation activity of the amentoflavone-zinc complex is superior to that of amentoflavone. By means of the formation of the amentoflavone-zinc complex, the anti-tumor activity and the anti-oxidation activity of amentoflavone are improved, and the complex is expected to be used for developing drugs.
Chemotherapy induced peripheral neuropathy (CIPN): CIPN is a debilitating and often irreversible toxicity associated with various chemotherapy agents widely used in the treatment of both solid tumors and hematologic malignancies. Clinical trials with Taxane-based forms of chemotherapy, commonly used in the adjuvant treatment of breast cancer, have reported up to 33% grades 2-3 sensory neuropathy and up to 14% of motor neuropathy. Severity is closely related to chemotherapy dose and schedule. CIPN may also develop in up to 64% of patients treated with 12 cycles of Oxaliplatin based adjuvant chemotherapy, when assessed clinically and electro physiologically. Patients develop an axonal, predominately sensory peripheral neuropathy, of mild to moderate severity. Thermal hyperalgesia with cold allodynia was found to be a clinical marker of early oxaliplatin neurotoxicity and may predict severe neuropathy
PURPOSE:To obtain water and oil repellent powder, having high safety, excellent in water absorbency and water and oil repellency and capable of providing a cosmetic good in feeling of use without any makeup disorder by treating starch with a specific perfluoroalkylsilane. CONSTITUTION:(A) This water and oil repellent powder is obtained by treating starch (e.g. rice starch or dextrin) with a perfluoroalkylsilane of the formula (n is an integer of 1-15; Y<1> to Y<3> are alkyl, alkoxy or halogen, with the proviso that Y<1> to Y<3> are not simultaneously alkyl) in an amount of 0.2-50wt.%, preferably 1-20wt.% based on the starch. The powder is produced by dissolving, e.g. the perfluoroalkylsilane of the formula in a solvent (e.g. hexane or ethanol), adding the starch thereto, mixing both at 20-150 deg.C, preferably 40-130 deg.C and filtering the obtained mixture or distilling away the solvent. (B) A cosmetic is prepared by blending the water and oil repellent powder (A) in an amount within the range of 20-70wt.%, preferably 30-60wt.% based on a cosmetic (e.g. a foundation or a rouge) therewith.
You will be assigned randomly (like tossing a coin) to receive either antibiotics or a placebo (sugar pill). Neither you nor your doctor will know which you are receiving. You will learn to give yourself the injection, and you will remain on your study drug for 28 days. A home health care nurse will visit you twice a week to check the injection site, and at weeks 1 and 3 the nurse will draw blood for laboratory tests. At months 1 and 6, you will be examined to see if you have fewer chronic fatigue symptoms after the antibiotics. This will include a fatigue questionnaire, a test of your mental processing speed, and a test of your cerebrospinal fluid.
Myelosuppression, including pancytopenia, leukopenia and anemia, some with fatal outcomes, have occurred with temozolomide [see Adverse Reactions (6.1, 6.2)]. Geriatric patients and women have been shown in clinical trials to have a higher risk of developing myelosuppression. 

Prior to dosing, patients must have an ANC of 1.5 x 109/L or greater and a platelet count of 100 x 109/L or greater. 

For the concomitant phase with radiotherapy, obtain a complete blood count prior to initiation of treatment and weekly during treatment [see Dosage and Administration (2.1)]. 

For the 28-day treatment cycles, obtain a complete blood count prior to treatment on Day 1 and on Day 22 of each cycle. Perform complete blood counts weekly until recovery if the ANC falls below 1.5 x 109/L and the platelet count falls below 100 x 109/L [see Dosage and Administration (2.1, 2.2)].
Public transport disruptions are conducive to disorientation narratives in which the temporal aspects of the experience are central, but it is difficult to collect psychometric data at the moment of disruption to quantify the occurring underlying feelings. We propose a new real-time survey distribution method based on travellers' interaction with disruption announcements on social media. We analyse 456 responses in the Paris area and find that travellers experience time slowing down and their destination feeling temporally farther away when undergoing traffic disruptions. Time dilation is more pronounced for people filling out the survey while still presently experiencing the disruption, suggesting that over time people remember a compressed version of their disorientation. Conflicted time feelings about the disruption, e.g., both faster and slower feelings of the passage of time, appear the longer the recollection delay. Travellers in a stopped train seem to change their itinerary not because the alternative journey feels shorter (it does not), but because it makes time pass faster. Time distortions are phenomenological hallmarks of public transport disruptions, but these distortions are poor predictors of confusion per se. Public transport operators can alleviate the time dilation experienced by their travellers by clearly stating whether they should reorient or wait for recovery when incidents occur. Our real-time survey distribution method can be used for the psychological study of crises, where a timely and targeted distribution is of paramount importance.
Carestream Health, Inc. will investigate the imaging performance of the CARESTREAM Vue PACS v12.2 Magnetic Resonance (MR) Perfusion and Diffusion Weighted Imaging ("investigational device") performance. Evaluation of MR Dynamic Susceptibility Contrast-Enhanced Perfusion Weighted Imaging (DSC-Perfusion), MR Diffusion Weighted Imaging (DWI) and MR Diffusion Tensor Imaging (DTI) was compared to the predicate device, the Olea Sphere PACS with Perfusion and DWI Modules. MR DSC-Perfusion of the brain is a method for evaluating blood flow in the brain and producing optimized parametric maps that help visualize this blood flow. MR DWI is a method to evaluate the motion of water molecules within bodily tissues. MR DTI is an extension of DWI that allows extraction of the diffusion tensor. The purpose of this study is to demonstrate equivalent clinical quality between the investigational and predicate devices using a radiologist evaluation of key metrics which are applicable to MR DSC-Perfusion, MR DWI, and MR DTI images.
Systems, computer readable instructions, and methods for dispensing and tracking medical products in various medical locations are disclosed. For example, the system may include a server that receives one or more requests for various types of medical products from one or more client devices, determines whether the requested types and quantities are available in a dispenser, and issues instructions to the dispenser to automatically dispense the requested medical products and quantities. The server may receive confirmation and update the database after dispensing the types of medical products from the dispenser. The server may receive unused and used medical product information from the client device and check the information against the re-catalogued medical product information from the dispenser. The available types of medical products and quantities, usage reports, and recommendations may be viewable by one or more client devices via the platform. The dispenser may receive a request for a medical product directly from a client device.
AIMS: Heart failure with reduced ejection fraction (HFrEF) significantly impacts health-related quality of life (HR-QoL). Existing HR-QoL questionnaires can show inconsistencies, potentially misrepresenting patient self-reports. This study examines the variation in HR-QoL measurement tools for HFrEF patients, identifying related determinants.
METHODS AND RESULTS: We retrospectively analysed 134 hospitalized patients with acute decompensated HFrEF at a Taiwanese tertiary centre's Heart Failure Post-Acute-Care (HF-PAC) programme. Participants completed the EuroQol-5 dimension (EQ-5D) questionnaire, the EQ-5D visual analogue scale (VAS), and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Utility values were obtained from the EQ-5D questionnaire. Demographic features were depicted using descriptive statistics, while multivariate regression was used to ascertain relationships between HR-QoL measurements and determinants. Average scores for EQ-5D, MLHFQ, EQ-5D utility, and VAS were 6.1 ± 1.6, 21.8 ± 21.3, 81.7 ± 27.0, and 59.5 ± 14.6, respectively. Significant correlations were observed among the three tools. The New York Heart Association functional class showed a notable association with all tool scores. Other associations encompassed EQ-5D with coronary artery disease, mineralocorticoid receptor antagonists, and the 6 min walk test; EQ-5D VAS with chronic kidney disease; and MLHFQ with age.
CONCLUSIONS: This study illuminates the variance in HR-QoL measurement tools for Taiwanese HFrEF patients. Using a range of these tools is beneficial in unveiling diverse determinants and approaching comprehensive patient-centred care. However, for a more precise HR-QoL assessment in Taiwanese HFrEF patients, recalibrating the EQ-5D-derived utility scores might be necessary, emphasizing the importance of patient-specific considerations within the HF-PAC programme.
According to the present invention, scrubbing colored salt or colored sugar coated with natural vegetable pigments, that have various physiological effects such as antioxidant and anti-cancer effects, are coated with water-soluble natural pigments that have various physiological activities. Thus, when the scrubbing colored salt or colored sugar is dissolved in water, the coated natural pigments are dissolved in water to exhibit various physiological effects on skin and to have a skin protection effect of preventing oxidation. Also, due to the coating of the natural pigments, the dissolution rate of the salt or sugar in water is adjusted, and thus it is possible to remove dead skin cells despite a small amount due to the presence of the salt or sugar in the form of particles. The scrubbing colored salt or colored sugar coated with natural vegetable pigments that have various physiological effects such as antioxidant and anti-cancer effects according to the present invention can be produced to have one color selected from the group consisting of yellow, red, purple, orange, turquoise, and green, or a mixed color of two or more thereof. In addition, when the scrubbing colored salt or colored sugar is used for a scrub composition, a skin antioxidant effect, a skin exfoliation effect, a skin moisturizing effect, and a skin mineral supply effect are ensured due to the natural pigments. Also, functional colored scrub agents with a variety of colors that meet consumer preferences can be produced.
Neuromuscular electrical stimulation (NMES) is to be applied using a custom-built, two-channel stimulator, Bioelectronics Research Cluster, National University of Ireland, Galway) with a frequency of 36 Hz, a balanced biphasic waveform with a pulse width of 350μs, a ramp up time of 500ms, a contraction time of 1s and a ramp down time of 500ms. Stimulation is to be applied every 20 seconds over a period of 90 minutes. Its affect on oedema reduction, joint mobility and skin oxygenation will be assessed both before and after its application.
Speed of response in the treatment of sepsis is crucial for the patient. The time from the collection of a positive haemoculture to the identification of the causative agent of sepsis is around 2 days; therefore, physicians in intensive care units deploy combined empiric antibiotic and antifungal therapy immediately when acute phase markers such as procalcitonin, interleukin-6, Presepsin, C-reactive protein are elevated. A new acute phase marker is lipopolysaccharide-binding protein, which, together with Presepsin, appears to be a suitable marker to distinguish invasive candida infections from bacterial infections. But its kinetics needs to be further analyzed.

At the same time, the causative agent of sepsis, G-/G+ bacteria or yeast, must be identified as soon as possible. Haemoculture and culture of the established drain is the gold standard, but the disadvantage is the low sensitivity and the time delay to obtain the result. It is therefore advisable to combine haemoculture with molecular biology-based tests that can identify the causative organism within hours. Conversely, the disadvantage of these tests is that they identify only the most common sepsis pathogens and do not determine susceptibility to antibiotics and antifungals, but the advantage is that with prophylaxis in place, these tests are often positive when haemoculture is negative. The T2Candida test can detect Candida albicans, Candida tropicalis, Candida glabrata, Candida krusei and Candida parapsilosis, which are the more common causative agents of mycotic bloodstream infections.
BACKGROUND: Human papillomavirus (HPV), the most common pathogen causing sexually transmitted diseases worldwide, is also an oncogenic virus. Due to the inadequacy of serologic tests in the diagnosis of HPV, NAATs (nucleic acid amplification tests), such as PCR (polymerase chain reaction), represent the gold standard today. Endocervical brush sampling in women has been successfully used for HPV genotyping for many years. The aim of this study was to determine the diagnostic efficacy for PCR HPV genotyping of multisite samples taken simultaneously with a swab from the external genitalia in addition to endocervical brush sampling in women applying for Hr-HPV screening.
METHODS: This study included 105 asymptomatic patients who came to the Gynecology Polyclinic of the University of Health Sciences Tepecik Training and Research Hospital between February 2023 and June 2023 for control purposes. Both the samples taken with a brush from the cervical area and the samples taken with a swab from the external genital area were sent to a screening laboratory for testing for Hr-HPV DNA. The samples were analyzed by real time PCR.
RESULTS: The success rate of positive detection of swab samples of HPV type 16 was significantly higher, with a difference of 17.6% (p < 0.0001). For HPV type 18, the swab sample had a significantly higher positive detection rate, with a difference of 60.0% (p = 0.002).
CONCLUSIONS: The results of this study show that HPV genotyping from the external genital area can be performed as an alternative to cervical sampling in sexually active women to increase the reach of a screening program.
The average diameter of the nanoparticles used can be close to or smaller than the diameter of the virus, resulting in a small size effect: A. suspension isolation effect: after the nanoparticles enter a human body, the nanoparticles can generate a nanometer suspension isolation effect, so that virus replication can be blocked to a certain extent. B. Surface adsorption effect: after the nano particles enter a human body, the surface area of the nano particles is greatly expanded, so that the adsorption effect of the nano particles is increased, and viruses, metabolites of the viruses and virus replication parts can be adsorbed. After adsorption, the product is metabolized and discharged. C. Rubbing effect: after the nano particles enter a human body, the nano friction mechanical effect of the particles generates friction with continuously rotating cells, so that viruses are difficult to attach to the surfaces of the cells, and the viruses are blocked from entering the cells. The virus attached to the cell surface can be scrubbed off by utilizing the mechanical effect of nano friction, so that the transcription opportunity is cut off and the virus is completely cured.
The intervention group is provided access to the dayzz app, a personalized digital sleep training program. The sleep training begins a sleep assessment questionnaire and ongoing sleep and activity data collection which is used to tailor an individualized sleep training program including behavioral and cognitive techniques to improve the insomnia concerns, sleep symptoms, and achieve sleep goals. The dayzz sleep program is composed of three main components, (1) a mobile digital program via the dayzz app, (2) guidance of a sleep trainer, and (3) an ambulatory sleep monitoring device.
OBJECTIVE: Among those with bulimia nervosa, weight suppression has been associated with illness severity and treatment prognosis. Although significant weight loss is known to reduce metabolic rate, the relation between weight suppression and resting energy expenditure (REE) in bulimia nervosa has not been examined. This study tested the hypothesis of an inverse relation between weight suppression and REE in a sample of women with bulimia nervosa (N = 84).
METHODS: In primary analyses, linear regressions were conducted between weight suppression and REE, corrected for fat-free mass. In follow-up, exploratory analyses, stepwise linear regressions were conducted to explore the main and interaction effects of weight history and weight suppression on REE.
RESULTS: Neither traditional (TWS) nor developmental weight suppression (DWS) correlated with REE. Results from exploratory analyses, however, revealed a medium-to-large inverse relation between several weight history variables and REE (highest past weight, sr2 = 0.05; lowest postmorbid weight, sr2 = 0.07; current weight, sr2 = 0.05). Additionally, DWS interacted with current (sr2 = 0.08) and highest premorbid (sr2 = 0.05) z-BMI to influence REE with a medium-to-large effect. For individuals low in current and premorbid z-BMIs, higher DWS associated with lower REE levels. However, for individuals at higher premorbid z-BMIs, higher DWS unexpectedly associated with greater REE levels.
DISCUSSION: In this sample of women with bulimia nervosa, reduced REE associated with higher weights across all timepoints. If the interaction effect between DWS and z-BMI history persists in future studies, this may indicate unique challenges faced by individuals low in z-BMI and high in DWS related to weight gain and normalization of eating.
Optional third mRNA-1273 vaccination sub-study. 100 mcg of mRNA-1273 administered through 0.5 mL intramuscular injection in the deltoid muscle no later than Day 394 in participants from Arm 2,3,5 and 8 from 18 years of age or older. N=50.