anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Voluntary information form will be read to those who want to participate in the research, verbal and written permissions will be obtained and information will be given about fetal development and Leopold maneuvers in the pregnant follow-up room of the family health center. This transaction is 28-32. 32-38 at the next follow-up at gestational weeks. Pregnancy will be carried out with the same procedure.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to veterinary science, and can be used in preparing the rabies virus antigen for serological diagnosis. That is ensured by preparing a suspension of brain white mice experimentally infected with rabies virus. Brain tissue is homogenised in 0.1 M phosphate-buffer solution at pH 7.2–7.4. Obtained cerebral suspension is held in test tubes for at least 5 minutes until complete precipitation of silicon carbide balls. Supernatant is taken and 0.1 M phosphate-buffer solution is added to the test tubes, then shaken 3 times, held for at least 5 minutes and centrifuged for 50 minutes at 5,000 rpm. Supernatant is concentrated by ultracentrifugation at 37,000 rpm for 4 hours. Supernatant is then removed and the resulting resuspended residue is layered on a step gradient of 10–60 % sucrose. Ultracentrifugation for 3 hours at 30,000 rpm at temperature of +40 °C viral material is then fractionated by gel filtration. Immunoblot results are used to select active fractions, re-precipitate them with alcohol and obtain an antigen of rabies virus.EFFECT: invention increases specificity and sensitivity of the obtained antigen and increases output of the active antigen.1 cl, 1 tbl, 6 dwg
CLINICAL REGISTRY OBSERVATION NATURE

This serves as a registration trial evaluating short, intermediate, and long-term outcomes of patients treated with targeted laser ablation of biopsy confirmed prostate cancer. The primary outcome measure is 1-year oncological control of the targeted ablated area. The following secondary aims are sought: PROCEDURE RELATED: tolerability, feasibility, pain during this office-based procedure. PERIOPERATIVE: Adverse Events (AEs) and Series AEs profile during the initial 90 days after the procedure. ONCOLOGIC - In addition to primary aim, determine risk and rate of emergence of de-novo tumors (so called Outfield Recurrence) at the 1 year fusion biopsy mark and overtime. Will also observe rate of progression locally and systemically. Conversion to whole gland treatment - surgery extraction, radiation or whole gland cryoablation is of particular interest as is the initiation of androgen suppression (castration). Moreover, the investigators will evaluate the impact of MRI in assessing tumor locations and of software registration guiding the location and extent of ablation of the laser ablation over fixed time intervals. Finally, incidence of metastatic disease - non castrate and castrate - as well as cancer specific and overall survival at 5, 10 and 15 years post procedure. FUNCTIONAL OUTCOMES - determine urinary function and sexual function including incidence of ejaculation, and climacturia at months 3, 6 and 12. These outcomes will then measured yearly for the extent of the study
MJ users assigned to this condition will participate in 4 individualized intervention sessions that are based on Motivational Interviewing principles. They will only receive personalized feedback on their MJ use.
Age-Related Macular Degeneration (AMD) is a disease that affects central part of the retina, called macula, and is associated with progressive central vision loss. Moreover, AMD is known to be a leading cause of blindness in developed countries. In wet form of AMD, new abnormal blood vessels start to grow from the choroid towards the retina that leads to leakage from these vessels and, in turn, to impaired retinal structure and rapid vision loss.

Genetic factors were found to be important in development of wet AMD. Our previous research showed the association between some genetic polymorphisms and the risk of wet AMD as well as with specific clinical features of the disease. At present, anti-vascular endothelial growth factor (anti-VEGF) therapy with intravitreous ranibizumab (Lucentis) is considered to be the most effective treatment for wet AMD. However, treatment outcomes may vary significantly from improved vision to no effect. The aim of this research is to study how ranibizumab treatment outcomes depend on genetic factors.
To provide an aerosol spray hairdressing agent for simply making pompadour hair.SOLUTION: Provided is an aerosol spray hairdressing agent. The composition of the hairdressing agent can be sprayed in the form of a mist. The hairdressing composition comprises a film-forming polymer (component A), a polyoxyethylene hardened castor oil having an average number of added moles of ethylene oxide of 35 to 120 (component B), a polyoxyethylene alkyl ether having an average number of added moles of ethylene oxide of 10 to 50 and having a cetyl group or a stearyl group (Component C), water (component D), and ethanol (component E). The composition comprises 0.5 to 10.0 mass% of Component A, 9.0 to 45.0 mass% of Components B and C in total, and 35.0 to 90.5 mass% of Components D and E in total. The mass ratio (Component C/Component B + Component C) is 0.4 or more, and the mass ratio (Component D/Component D + Component E) is 0.05 to 0.45. Propellants include liquefied petroleum gas.SELECTED DRAWING: Figure 1
The population of people in federal custody in Canada is aging. Those in custody report experiencing poorer health and high rates of chronic health conditions. Two health concerns that are disproportionately higher among those in custody are mood disorders and pain. This cross-sectional study examined health indicators associated with pain and depressive symptoms among older people (50 years and above) from multiple facilities and security levels in federal custody in Canada. Participants were assessed using the interRAI Emergency Department Contact Assessment, which captures key health indicators. Chi square and logistic regression analyses were conducted to describe the population and identify health indicators associated with mood- and pain-related outcomes, respectively. Of the 1,422 participants in this study, the majority (55%) experienced pain and at least 1 out of 5 experienced depressive symptoms. Health indicators associated with depressive symptoms and/or pain were functional measures, including mobility, managing medication(s), and dyspnea. Depressive symptoms and pain are highly prevalent among older adults in federal custody. The relationship between functional health, depressive symptoms, and pain highlights the importance of interprofessional health care and biopsychosocial intervention(s).
PCT No. PCT/EP96/01654 Sec. 371 Date Jan. 28, 1998 Sec. 102(e) Date Jan. 28, 1998 PCT Filed Apr. 19, 1996 PCT Pub. No. WO96/33192 PCT Pub. Date Oct. 24, 1996The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, halogen, CF3, amino, nitro, cyano, acylamino, alkoxy, acyl, phenyl, and monocyclic heteroaryl, and one of R6 and R7 is hydrogen and the other is pyrrolyl which may be substituted one or more times with substituents selected from halohen, alkyl, phenyl, and alkoxy. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
Bilateral abdominal sacral hysteropexy will be perform in 10 patients. One month after patients will be evaluate by MRI and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) form.
Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R, 7R)-7-[2-(2-Amino-4-thiazolyl) glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.

The chemical formula of ceftriaxone sodium is C18H16N8Na2O7S3•3.5H2O. It has a calculated molecular weight of 661.60 and the following structural formula:

Ceftriaxone sodium is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of ceftriaxone solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used.

Each Pharmacy Bulk Package is supplied as a dry powder in Pharmacy Bulk Package bottles containing sterile Ceftriaxone Sodium, USP equivalent to 10 grams of ceftriaxone and is intended for intravenous infusion only. Ceftriaxone sodium contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity.

A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. FURTHER DILUTION IS REQUIRED BEFORE USE. (See DOSAGE AND ADMINISTRATION, and DIRECTIONS FOR PROPER USE OF PHARMACY BULK PACKAGE.)
<P>PROBLEM TO BE SOLVED: To obtain an immunotherapeutic agent effective for treatment and prevention of metastasis and recurrence of malignant tumors of hematopoietic organs such as multiple myeloma, leukemia, malignant lymphoma, etc., and solid cancers such as lung cancer, breast cancer, etc., and to provide an immunotherapy using the preparation.  <P>SOLUTION: The synthetic peptide is derived from human myeloma HM1.24 protein. The antigen has the peptide. The DNA molecule encodes the peptide. The dendritic cells are sensitized with the peptide or the antigen presenting cells are derived from the antigen. The cytotoxic T lymphocyte is derived from the peptide. The immunotherapeutic agent is excellently effective for treatment and prevention of metastasis and recurrence of malignant tumors of hematopoietic organs such as multiple myeloma, leukemia, malignant lymphoma, etc., and solid cancers such as lung cancer, breast cancer, etc., and is safe.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
OBJECTIVES: This study aimed to identify the risk factors and construct the diagnostic model associated with pneumocystis pneumonia (PCP) in pediatric patients.
METHODS: This retrospective observational study analyzed 34 cases of PCP and 51 cases of other types of pneumonia treated at Children's Hospital Affiliated to Shandong University between January 2021 and August 2023. Multivariate binary logistic regression was used to identify the risk factors associated with PCP. Receiver operating characteristic curves and calibration plots were constructed to evaluate the diagnostic model.
RESULTS: Twenty clinical variables significantly differed between the PCP and non-PCP groups. Multivariate binary logistic regression analysis revealed that dyspnea, body temperature>36.5°C, and age<1.46 years old were risk factors for PCP. The area under the curve of the diagnostic model was 0.958, the P-value of Hosmer-Lemeshow calibration test was 0.346, the R2 of the calibration plot for the actual and predicted probability of PCP was 0.9555 (P<0.001), and the mean Brier score was 0.069. In addition, metagenomic next-generation sequencing revealed 79.41% (27/34) and 52.93% (28/53) mixed infections in the PCP and non-PCP groups, respectively. There was significantly more co-infection with cytomegalovirus and Streptococcus pneumoniae in the PCP group than that in the non-PCP group (p<0.05).
CONCLUSIONS: Dyspnea, body temperature>36.5°C, and age<1.46 years old were found to be independent risk factors for PCP in pediatric patients. The probability of co-infection with cytomegalovirus and S. pneumoniae in the PCP group was significantly higher than that in the non-PCP group.
This is an open-label, feasibility study comparing the tissue temperature profile of a 950 nm LED device and a 1060 nm diode laser for non-invasive lipolysis of the flanks. The study will enroll up to 10 subjects requesting non-invasive lipolysis of the flanks. Each subject will receive a single treatment with each device on opposite flanks. Tissue temperatures in the treated areas will be recorded at various tissue depths and compared. Subjects will be asked to assess their discomfort and pain of the study treatment using a 10 cm visual analog scale (VAS). In addition, the safety (number of treatment related adverse events) of the LED device will be compared to the reference device at the time of treatment and one week later.
BACKGROUND: As a minimally invasive technique, robot-assisted hysterectomy (RAH) offers surgical advantages and significant reduction in morbidity compared to open surgery. Despite the increasing use of RAH in benign gynaecology, there is limited data on its cost-effectiveness, especially in a European context. Our goal is to assess the costs of the different hysterectomy approaches, to describe their clinical outcomes, and to evaluate the impact of introduction of RAH on the rates of different types of hysterectomy.
METHODS: A retrospective single-centre cost-analysis was performed for patients undergoing a hysterectomy for benign indications. Abdominal hysterectomy (AH), vaginal hysterectomy (VH), laparoscopic hysterectomy (LH), laparoscopically assisted vaginal hysterectomy (LAVH) and RAH were included. We considered the costs of operating room and hospital stay for the different hysterectomy techniques using the "Activity Centre-Care program model". We report on intra- and postoperative complications for the different approaches as well as their cost relationship.
RESULTS: Between January 2014 and December 2021, 830 patients were operated; 67 underwent VH (8%), 108 LAVH (13%), 351 LH (42%), 148 RAH (18%) and 156 AH (19%). After the implementation and learning curve of a dedicated program for RAH in 2018, AH declined from 27.3% in 2014-2017, to 22.1% in 2018 and 6.9 % in 2019-2021. The reintervention rate was 3-4% for all surgical techniques. Pharmacological interventions and blood transfusions were performed after AH in 28%, and in 17-22% of the other approaches. AH had the highest hospital stay cost with an average of €2236.40. Mean cost of the hospital stay ranged from €1136.77-€1560.66 for minimally invasive techniques. The average total costs for RAH were €6528.10 compared to €4400.95 for AH.
CONCLUSION: Implementation of RAH resulted in a substantial decrease of open surgery rate. However, RAH remains the most expensive technique in our cohort, mainly due to high material and depreciation costs. Therefore, RAH should not be considered for every patient, but for those who would otherwise need more invasive surgery, with higher risk of complications. Future prospective studies should focus on the societal costs and patient reported outcomes, in order to do cost-benefit analysis and further evaluate the exact value of RAH in the current healthcare setting.
FIELD: medicine, neurology. SUBSTANCE: one should conduct acupuncture reflexotherapy, postisometric relaxation of spasmodic muscles, after vacuum evaporation it is necessary to puncture neuroosteofibrous foci and periosteal incisions in the projection of palpationally revealed indurations. After hemorrhage stoppage a leech should be put onto a site of puncture. About 3-10 leeches are put onto the area of affected disks. A course is finished with a complex including a medicinal blockade, curative physical culture, applications of dimexide-curative mixture onto both gluteal and lumbar areas. In the course of therapy it is necessary to measure cutaneous potential. EFFECT: higher efficiency of therapy. 2 ex
The present invention relates to an anti-anoxia medicinal compound. The utility model is characterized in that the components of medicine comprise the combination of at least two kinds of taurine, vitamin C and arginine according to the proportioning relation of 0 to 5 weight parts of taurine, 0 to 6 weight parts of vitamin C and 0 to 5 weight parts of arginine. The components are prepared into acceptable oral-administration preparations and health foods on the pharmacy according to conventional technique. The present invention has the characteristic that the medicinal compound has the effects of resisting anoxic damage, inhibiting lipid peroxidation, increasing NO yield, relieving the anoxic hypertension of pulmonary arteries and reducing the hypertrophy degree of a right ventricle. The medicine has the function of promoting the adaptation of anoxic namely promoting acclimatization. The medicine is ideal medicine for preventing mountain anoxia and prevention and curing the hypertension of pulmonary arteries.
Impaired sleep affects millions of people each year representing an important public health issue. This project will utilize metabolomics approaches to identify potential mechanisms underlying increased cardiometabolic risk associated with insufficient sleep and to identify potential biomarkers in the blood that respond to insufficient sleep. Investigators will conduct a controlled in-laboratory insufficient protocol where participants will sleep in the lab for one night with sleep timing based on their habitual insufficient sleep schedule. In the morning, plasma will be collected for metabolomics analyses and participants will complete an oral glucose tolerance test for insulin sensitivity analyses. Participants will then complete a 4 -week increased sleep duration intervention targeting the recommended 7 hours of sleep per night. Following this intervention participants will again sleep in the lab for one night on their new sleep schedule. In the morning, plasma will be collected for metabolomics analyses and participants will complete an oral glucose tolerance test for insulin sensitivity analyses. Investigators anticipate these findings will be the first step in developing biomarkers of impaired sleep under free-living sleep conditions, and to determine how such biomarkers relate to insulin sensitivity changes associated with sleep loss.
Since 1998, University of Connecticut (UCONN) undergraduate students have volunteered as part of a service- learning course to deliver a program called Husky Reads. Inspired by the nationally accepted American Academy of Pediatrics' program "Reach Out and Read," Husky Reads was first designed for promotion of health, nutrition habits and literacy by reading health-oriented books to young children in pediatric and health clinics. The Husky Reads curriculum now includes a series of 10 lessons designed to introduce preschool-age children to MyPlate while improving fruit and vegetable literacy. Each lesson includes reading at least one children's book, an activity or game, and food tasting to complement learning objectives related to MyPlate and fruit/vegetable literacy. Undergraduate students enrolled in the Husky Reads service- learning course at UConn or college students participating in the paid summer internship program deliver the preschool lessons. Each team of 2-3 undergraduate students is assigned 2-3 early care classrooms to visit and deliver Husky Reads lessons to on a weekly basis. This series targets children at an early age because early childhood is a pivotal time to influence the path towards healthy behaviors and away from obesity. Providing food tastings and increasing exposure to foods like fruits and vegetables is especially relevant because food preferences are developed in early childhood. Early childhood is also an important time for introducing healthy behaviors because once obesity is established in childhood; it often tracks through to adulthood and is difficult to reverse through interventions.

The effectiveness of the Husky Reads curriculum on a preschool age child's MyPlate knowledge and correct identification and liking of fruits and vegetables has not been established. A more comprehensive evaluation is needed to establish if the program is effective and contributes to quality improvement efforts. Findings from a prior evaluation suggest the ability of preschoolers to identify blueberries, strawberries, carrots and broccoli increased significantly after participation in one Husky Reads lesson. Although the findings were promising, the evaluation design lacked a control group and relied on a classroom wide assessment with hands raised as a response rather than measuring whether the ability to identify the produce items changed for a given child after participation in Husky Reads. Therefore, a more thorough evaluation of whether Husky Reads helps children learn to identify select fruits and vegetables is still needed. Questions also remain whether Husky Reads increases the odds of a child tasting and/or liking select fruits and vegetables as well as recognition of MyPlate and foods in different food groups. The proposed evaluation uses a pre-test/post- test control group design with paired data at the child level to explore whether children who participate in Husky Reads have increased odds of identifying MyPlate and food group concepts , and correctly identifying,trying or liking select fruits and vegetables.
Our research team has established a polysomnography (PSG) quantified population-based paediatric sleep cohort in 2003 for a childhood OSA prevalence study. Subjects were recruited from 13 randomly selected primary schools. In each school, two randomly chosen classes from each grade were invited to participate. In the first phase, all parents of children in the randomly selected schools were invited to attend an education forum during which full explanation of the purpose and flow of the study was given. An envelope containing a validated parent proxy OSAS screening questionnaire and consent was then distributed to parents within a week after the forum. From our previous research, a composite symptom score (summation of the scores of these three questions) of 7 or more has 75.4% sensitivity and 80.5% specificity, compared with polysomnography, to detect OSAS among children aged 5-15 years who had attended our paediatric clinics. Children with a composite symptom score of less than 7 were assigned a computer-generated random number and were invited as a control group with a ratio of 1:2 in the second phase. All children belonging to the high risk of OSAS group and the randomly selected subjects at low risk of OSAS were invited to participate the baseline epidemiological study. In total 619 children aged 5-13 years underwent detailed assessments including anthropometric measurements, airway examination, ambulatory blood pressure recording and overnight PSG. 67 children had moderate-to-severe OSA (obstructive apnoea hypopnoea index, OAHI ≥5/h), 199 had mild OSA (OAHI 1 to \<5/h), 103 were primary snorers (OAHI \<1/h but snore ≥3 nights per week in the past 12 months) and 250 were normal controls (OAHI \<1/h and snore \<3 nights per week in the past 12 months).(1) All subjects from this original cohort will be invited to join this 18-year follow-up study to repeat the following data collection: questionnaires, anthropometric measurement, sleep study, 24-hour ambulatory blood pressure (ABP) measurement, echocardiography and neurocognitive assessment.
PCT No. PCT/US93/05176 Sec. 371 Date Mar. 7, 1995 Sec. 102(e) Date Mar. 7, 1995 PCT Filed Jun. 7, 1993 PCT Pub. No. WO93/25238 PCT Pub. Date Dec. 23, 1993A stable powder composition comprising an anti-fungal effective amount of an imidazole antifungal compound and talc coated with a hydrophobic coating is described. A method for stabilizing an imidazole antifungal compound in a talc composition is also described which comprises either using talc coated with a hydrophobic coating or coating talc with a hydrophobic coating, prior to adding the imidazole antifungal compound to the talc.