anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Many patients treated with ZANOSAR have experienced renal toxicity, as evidenced by azotemia, anuria, hypophosphatemia, glycosuria and renal tubular acidosis. Such toxicity is dose-related and cumulative and may be severe or fatal. Renal function must be monitored before and after each course of therapy. Serial urinalysis, blood urea nitrogen, plasma creatinine, serum electrolytes and creatinine clearance should be obtained prior to, at least weekly during, and for four weeks after drug administration. Serial urinalysis is particularly important for the early detection of proteinuria and should be quantitated with a 24 hour collection when proteinuria is detected. Mild proteinuria is one of the first signs of renal toxicity and may herald further deterioration of renal function. Reduction of the dose of ZANOSAR or discontinuation of treatment is suggested in the presence of significant renal toxicity. Adequate hydration may help reduce the risk of nephrotoxicity to renal tubular epithelium by decreasing renal and urinary concentration of the drug and its metabolites.

Use of ZANOSAR in patients with preexisting renal disease requires a judgment by the physician of potential benefit as opposed to the known risk of serious renal damage.

This drug should not be used in combination with or concomitantly with other potential nephrotoxins.

When exposed dermally, some rats developed benign tumors at the site of application of streptozocin. Consequently, streptozocin may pose a carcinogenic hazard following topical exposure if not properly handled. (See DOSAGE AND ADMINISTRATION.) See additional warnings at the beginning of this insert.
The present invention provides a network system for storage of medical records.                                              The records are stored in a database on a server. Each record includes two main parts, namely a collection of data elements containing information of medical nature for the certain individual, and a plurality of pointers providing addresses or remote locations where reside other medical data for that particular individual.  Each record also includes a data element indicative of the basic type of medical data found at the location pointed to by a particular pointer. This arrangement permits a client workstation to download the record along with the set of pointers which link the client to the remotely stored files.  The identification of the basic type of information that each pointer points to allows the physician to select the ones of interest and thus avoid downloading massive amounts of data where only part of that data is needed at that time.                     In addition, this record structure allows statistical queries to be effected without the necessity of accessing the data behind the pointers.                                                     For instance, a query can be built based on keys, one of which is the type of data that a pointer points to. The query can thus be performed solely on the basis of the pointers and the remaining information held in the record.
In this study, the investigators are going to compare two preparations of oral iron in treatment of iron deficiency anemia with pregnancy. a total of 300 pregnant women will be randomly divided into two equal groups (each containing 150 pregnant woman). one group will receive amino acid chelated iron and the other group will receive iron salt (ferrous fumarate). All pregnant women attending the obstetrics outpatient clinic of kasr al aini hospital at 14-18 weeks gestation will be submitted to complete blood picture and serum ferritin. those who prove to have iron deficiency anemia (hemoglobin less than 11g/dl and serum ferritin less than 12ug/l) will be included in the study. All eligible women will be followed up at 22-23, 29-30 and 36-37 weeks' gestation for the change in hemoglobin level and ferritin level. all women will be also enquired about different side effects during treatment period.
FIELD: medicine, experimental biology. SUBSTANCE: invention is devoted to the new class of compound of vitamin D 3 , - analogs of α-hydroxy-19-nor-vitaminD 3 , and the general method of synthesis of these compounds. These compounds show increased activity in relation to inhibition of non-differentiated cells proliferation including malignant ones, and also in relation to stimulation of proliferation. Proposed compounds are new drugs for cure of malignant neoplasm and other diseases showing proliferation of non-differentiated cells. Also, medicinal prescriptions using these compounds and methods of treatment are proposed. EFFECT: improved method of treatment. 2 cl
The invention belongs to the field of nano catalytic material preparation, and particularly relates to a preparation method of a CeO  2 /CuO 2  composite nano material with a synergistic catalytic function, an obtained product and application. According to the invention, inorganic nano-material cerium oxide (CeO  2 ) is combined with copper peroxide (CuO  2 ), and then a chemotherapeutic drug Doxorubicin (DOX) is loaded and Hyaluronic Acid (HA) is further modified, so that the CeO  2 /CuO 2  composite nano-material with the synergistic catalytic function is prepared. The CeO  2 /CuO 2  composite nano material provided by the invention can solve the problem of hypoxia in tumor treatment and improve the chemotherapy effect. CeO  2  has better catalase activity, and can catalyze H  2 O 2  in cells to decompose to generate a large amount of O  2  in an acidic environment of tumors, so that the anoxic condition of the tumors is relieved, and the chemotherapeutic effect of DOX is improved. The CeO  2 /CuO 2  composite nano material provided by the invention can solve the problem of insufficient H  2 O 2  content and improve the catalysis effect of Fenton-like reaction. The CuO  2  nano particles loaded by CeO  2  can be decomposed and released to release H  2 O 2  in the slightly acidic environment of tumor cells, so that the H  2 O 2  content of tumor tissues can be improved, the concentration of OH is improved through Fenton reaction, and the CDT effect is enhanced.
INTRODUCTION: Tonsillectomy is a frequently performed otolaryngological procedure and is associated with significant postoperative pain and bleeding. A number of studies have investigated methods to reduce pain and bleeding. Coblation and BiZact devices have both been claimed to have favourable pain outcomes following tonsillectomy. This study was designed to investigate these two techniques in a direct comparison of postoperative pain and bleeding.
METHODS: In this single blinded, randomized control trial, 61 patients were randomly assigned to undergo tonsillectomy with either the BiZact or Coblation device. Pain scores were collected for 14 days postoperatively using a Visual Analogue Score scale. Secondary outcome data was collected for duration of surgery, intra-operative bleeding, return to normal, and secondary bleeding rates.
RESULTS: Coblation was found to have lower postoperative pain on day 1 (P < 0.05). BiZact was found to have lower postoperative pain on day 7 (P < 0.05) and day 11 (P < 0.05). Pain scores for other days were not significant. There was no significant difference in set-up time, procedural time and return to normal activities. The BiZact group had a longer time to achieve haemostasis (P < 0.001) and greater intraoperative blood loss (P < 0.01). There was a trend towards more significant secondary bleeding in the BiZact arm, however, this study was not adequately powered to assess this finding.
CONCLUSION: Both Coblation and BiZact devices appear to provide a safe and effective method for tonsillectomy in adults. Reduced pain on day 1 may make Coblation more suitable for day-case surgery.
OBJECTIVE: The lack of indicators to measure tumor's invasive biological behavior is an important issue. The aim of this study was to examine the effect of miRNAs 129 and 145 on tumor progression as well as patient survival.
METHOD: Seventy five breast cancer (BC) patients and 75 controls were included in this research. Two miRNA expressions were estimated using real-time PCR. Biomarkers for BC detection was tested using ROC curves and AUC.
RESULT: miR-129 and miR-145 expressions were significant. miR-129 and miR-145 classifiers (AUC = 0.943 and 0.748, respectively) help diagnose BC. Unlike miR-145, miR-129 did not affect the Kaplan-Meier survival curve analysis for progression-free survival at the end of the trial. The development of transitional cell carcinoma disease was found to have a strong correlation with miR-145 in both univariate and multivariate Cox regression analyses. Additionally, infiltrating + invasive urothelial carcinoma was also found to be correlated with miR-145. Conversely, elevated miR-129 expression in BC patients did not lead to an increase in cancer-specific recurrence or mortality, as observed in both univariate and multivariate Cox regression studies.
CONCLUSION: The miRNA signature can help detect survival-associated miRNAs and develop BC miRNA therapeutics.
The invention discloses a drug for treating chronic maxillary sinusitis. The drug as a traditional Chinese medicine composition comprises, by weight, 1-30 parts of cocklebur fruit, 1-20 parts of flos magnoliae liliflorae, 1-20 parts of notopterygium root, 1-15 parts of asarum herb, 1-50 parts of dahurian angelica root, 1-50 parts of balloonflower root, 1-40 parts of radix scutellariae, 1-60 parts of honeysuckle flower, 1-80 parts of gypsum, 1-20 parts of mint and 1-30 parts of licorice root. The drug can treat chronic maxillary sinusitis by treating cold, relieving stuffy nose and treating respiratory tract infection and can relieve symptoms by cleaning heat and removing toxins, and diminishing swelling and pus. Through compatibility, all the raw materials of the drug mutually cooperate and produce the optimal curative effects. The preparation method of an oral liquid containing the drug for treating chronic maxillary sinusitis has simple processes. The leached oral liquid can be fast absorbed by the human body and produce effects fast. Through a condensation technology, an oral liquid dosage is reduced and the oral liquid is convenient for carrying, preservation and taking.
NEW MATERIAL:The piperidine compound of formula I [R1m R3 and R4 are H or acyl; R2 is group of formula II-IV (each bonding at the left end)]. USE:A calmodulin-inhibitor useful as a biochemical reagent or antitumor agent. PREPARATION:An ascidian is disintegrated, homogenized and extracted with a mixture of methanol and toluene (3:1). The extracted liquid is added with 1M of saline water, extracted with toluene and separated into toluene layer and water layer. The water layer is extracted with cholorform and the chloroform layer is concentrated and dried under reduced pressure. The obtained residue is dissolved in chloroform, adsorbed to a column filled with silica gel and subjected to reverse-phase high-performance liquid column chromatography to effect the separation of the compound of formula I.
This research study involves 5 visits for the breast cancer subjects and 3 visits for the healthy controls. The first visit includes the informed consent and a screening and the second and third visit for the study days before chemotherapy and the fourth and fifth visit for the study days after chemotherapy. For the first test day, 2 hours of the subjects time will be for urine and blood sample collection, and to ingest the deuterated water. Subjects are allowed to go home after and eat normally. On the second study day, subjects will arrive early that morning and a DXA scan will be performed first. For the duration of the study, subjects have to lie in the bed (except for bathroom privileges). They can watch tv or bring and use a book/tablet. The research nurse or study staff will be present in the human subject area to assist the subject if necessary. Subjects are not allowed to eat or drink during the second test day, except for the test drink (meal) and water. One IV catheter will be placed in a vein of the arm/hand for blood draws. The hand will be placed in a hot box during blood collection. Another IV catheter will be placed in the contra-lateral forearm for a primed and continuous infusion of 2H5-glycerol. Over the two day time period, a total of 100-120 ml of blood will be obtained over approximately 19 samples. Stable isotopes will be ingested on the first test day, added to the test drinks on the second test day after the second hour, and infused on the second day. On the second test day, subjects will fill out questionnaires and perform muscle function tests. After completion of the study, we will provide the subject with a meal.
BACKGROUND: Coexistent sarcopenia and frailty is more strongly associated with adverse health outcomes than each condition alone. As the importance of coexistent sarcopenia and frailty increases, exploring their underlying mechanisms is warranted. Recently, noncoding ribonucleic acids (RNAs) have been suggested as potential biomarkers of sarcopenia and frailty. This systematic review aimed to summarize noncoding RNAs commonly expressed in sarcopenia and frailty, and to search the predicted target genes and biological pathways of them.
METHODS: We systematically searched the literatures on PubMed, Embase, Cochrane Library, Web of Science, and Scopus for literature published till November 15, 2023. A total of 7,202 literatures were initially retrieved. After de-duplication, 34 studies (26 sarcopenia-related and 8 frailty-related) were full-text reviewed, and 15 studies (11 sarcopenia-related and 4 frailty-related) were finally included.
RESULTS: miR-29a-3p, miR-29b-3p, and miR-328 were identified as commonly expressed in same direction in sarcopenia and frailty. These microRNAs (miRNAs), identified in the literature search using PubMed, modulate transforming growth factor-β signaling via extracellular matrix components and calcineurin/nuclear factor of activated T cells 3 signaling via sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a, which are involved in regulating skeletal muscle fibrosis and the growth of slow-twitch muscle fibers, respectively. miR-155-5p, miR-486, and miR-23a-3p were also commonly expressed in two conditions, although in different or conflicting directions.
CONCLUSION: In this systematic review, we highlight the potential of shared miRNAs that exhibit consistent expression patterns as biomarkers for the early diagnosis and progression assessment of both sarcopenia and frailty.
BACKGROUND: The aim of this study was to investigate the experiences, barriers, and solutions in communication during the provision of care for people with intellectual developmental disabilities in Germany. As there are approximately 350,000 people living with intellectual or developmental disabilities in Germany, who rely on assistance when communicating with healthcare providers, this study was conducted to examine the communication challenges and potential solutions in this population. The analysis especially focused on the potentials of digital applications facilitating information transfer.
METHODS: Thirteen expert interviews were conducted using a structured interview guide with caregivers and medical providers to people with intellectual developmental disabilities. The interviews were analyzed using an inductive and deductive content analysis approach, according to Meuser and Nagel.
RESULTS: The results revealed that the provision of care for people with intellectual developmental disabilities was characterized by time constraints and uncertainty when caregivers lack experience in caring for this population. Additionally, information transfer increased in complexity due to an overload of individual information provided by caregivers verbally or paper-based as well due to the passive role of patients who were usually not actively involved in the communication process. With regard to the potential for integrating digital applications for information transfer, a controversy between opportunity and risk emerged.
CONCLUSION: The findings demonstrate that there is a need to implement training programs for professionals to enable them to offer improved health care for people with intellectual developmental disabilities. It is essential that caregivers are given sufficient time to communicate with patients, and that digital applications are utilized to support information transfer. Moreover, other research shows that digital applications offer new possibilities to communicate with people with intellectual developmental disabilities, such as the use of simplified or pictorial language. By addressing these communication challenges, healthcare professionals may be able to provide more effective and efficient care to this population. However, this requires further research, which addresses the controversial results regarding digital applications outlined in this paper.
PURPOSE:A preventing agent for carious teeth containing at least one of an extract of a plant source material, e.g. ginger, cumin or celery seed, with an organic solvent or steam distillation product as an active constitutent. CONSTITUTION:A preventing agent for carious teeth, obtained by incorporating 0.001-5wt%, preferably 0.1-2wt%, at least one of an extract obtained by extracting a plant source material shown in the table with an organic solvent or a steam distillation product with a composition for the oral cavity. A dentifrice, e.g. toothpaste, troche, mouthwash, solid mouth refrigerant, liquid mouth refrigerant, chewing gum or embrocation, etc. may be cited as the composition for the oral cavity suitable for the incorporation. A dentine reinforcing agent, e.g. sodium monofluorophosphate, a germicide, e.g. chlorohexidine, an anti-inflammatory agent, e.g. dihydrocholesterol, a tissue activating agent, e.g. hinokitiol, and lysozyme or common salt, etc. may be incorporated with the composition.
Embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for training a machine learning model comprising a hidden module and an output module and configured for identifying one of a plurality of original labels for an input. In accordance with one embodiment, a method is provided that includes generating sufficiently-labeled data comprising example-pairs each associated with a sufficient label. The sufficient label of an example-pair indicates whether a first and a second input example have the same original label. The method further includes training the hidden module using the sufficiently-labeled data, and subsequently, training the output module using a plurality of input examples each having an original label. The plurality of input examples may be a plurality of fully-labeled data. The method further includes automatically providing the resulting trained machine learning model for use in prediction tasks.
BACKGROUND: Avoiding excessive antibiotic treatment duration is a fundamental goal in antimicrobial stewardship. Manual collection of data is a time-consuming process, but a semi-automated approach for data extraction has been shown feasible for community-acquired infections (CAI). Extraction of data however may be more challenging in hospital-acquired infections (HAI). The aim of this study is to explore whether semi-automated data extraction of treatment duration is also feasible and accurate for HAI.
METHODS: Data from a university-affiliated hospital over the period 1-6-2020 until 1-6-2022 was used for this study. From the Electronic Health Record, raw data on prescriptions, registered indications and admissions was extracted and processed to define treatment courses. In addition, clinical notes including prescription instructions were obtained for the purpose of validation. The derived treatment course was compared to the registered indication and the actual length of treatment (LOT) in the clinical notes in a random sample of 5.7% of treatment courses, to assess the accuracy of the data for both CAI and HAI.
RESULTS: Included were 10.564 treatment courses of which 73.1% were CAI and 26.8% HAI. The registered indication matched the diagnosis as recorded in the clinical notes in 79% of treatment courses (79.2% CAI, 78.5% HAI). Higher error rates were seen in urinary tract infections (UTIs) (29.0%) and respiratory tract infections (RTIs) (20.5%) compared to intra-abdominal infections (7.4%), or skin or soft tissue infections (11.1%), mainly due to incorrect specification of the type of UTI or RTI. The LOT was accurately extracted in 98.5% of courses (CAI 98.2%, HAI 99.3%) when compared to prescriptions in the EHR. In 21% of cases however the LOT did not match with the clinical notes, mainly if patients received treatment from other health care providers preceding or following the present course.
CONCLUSION: Semi-automatic data extraction can yield reliable information about the indication and LOT in treatment courses of hospitalized patients, for both HAI and CAI. This can provide stewardship programs with a surveillance tool for all in-hospital treated infections, which can be used to achieve stewardship goals.
Participants in the control group will receive a weekly 3-hour group-based (group of 5 participants) programme containing stretching exercise, stress reduction and health education on dementia and stroke prevention for 6 months. The programme consists of low-intensity seated stretching, psychoeducation on stress management, various relaxation methods with practice as well as education on the causes, identification, treatment and prevention of stroke and dementia. Benefits of physical exercise will also be discussed but will its weight will be evenly balanced with other forms of evidence-based preventive strategies.
FIELD: food industry. SUBSTANCE: preparation containing polyvitamins, macro- and trace elements has adaptogens and/or detoxicants taken at amount 0.5-97 wt.-%. Adaptogens were used from plant and/or animal origin and preparation can contain additionally ethanol, apiculture products and binding substances. Preparation can be used in parapharmacology. EFFECT: enhanced effectiveness of preparation proposed. 9 cl
The invention relates to a medicine for treating onychomycosis. The medicine comprises the following components by weight: 10g of cortex acanthopanacis, 10g of chaulmoogra seed, 10g of laminaria japonica, 10g of clove, and 10g of fennel. A preparation method comprises the following steps: the above components are weighed according to the weight amount, and the components are boiled to a proper temperature. The obtained liquid can be used for soaking fingernails. Each soaking process lasts for 15 to 30 minutes and three soaking processes are required per day. The medicine can solve the problem of large side-effect, addiction, long treatment time and high recurrence rate after medicament discontinuance, and difficult radical treatment of the diseases and the like, and is applied to treating onychomycosis.
Patients walk for minimum 30 minutes per day and mobility is tracked with Xsens over 5-10 minutes up to discharge from hospital. Patients also mobilize (walk out of the bed) on first day post-surgery under supervision and assistant of attending nurse in the floor if the clinical situation allows.