anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The use of intrathecal drug delivery systems for the management of chronic non-cancer pain has been in practice for over 30 years. A recently published study from the University of Texas Medical Branch performed a retrospective review on the morphine microdose method in community-based clinics. The goal of the study was to examine the morphine microdose method in an outpatient setting and assess success of therapy, pain scores and dose escalation. Patients were successfully weaned off their systemic opioids, maintained in an opioid-free period for 4-6 weeks, and then underwent a microdose trial and implantation. The majority of patients were successfully managed on morphine monotherapy, with a significant reduction in pain scores, and dose escalations comparable to prior studies. No prospective studies have examined the microdose method in correlation with changes in pain sensitivity.

Several studies have looked at the use of various pain testing models to investigate the effects of chronic opioid therapy and changes in pain perception. A systematic review of the literature identified clinical studies incorporating measures of hyperalgesia in patients on chronic opioid therapy. This review was aimed at finding the optimal testing modality to evaluate pain threshold and tolerance to external stimuli, including mechanical (pressure, touch, injection), thermal (cold/heat), and electrical. Although the results did not reveal any one method with sufficient power, several prospective studies evaluating hyperalgesia with heat pain ratings have shown some promising results; two studies revealing significant changes in heat responses for opioid treatment groups, and one study demonstrating lower heat pain perception values following an opioid taper. The latter study of research pertaining to pain sensitivity changes following an opioid taper is lacking, and only recently was a study performed investigating changes in pressure threshold following transition from full mu agonist to buprenorphine. Little is known at this juncture how pain thresholds change due to opioid dose changes and/or route of delivery changes such as oral to intrathecal routes.
BACKGROUND Chylous ascites is defined as the development of lipid-rich ascitic fluid in the peritoneal cavity. The formation of chylous ascites revolves around non-portal-based and portal-based etiologies, and the diagnosis is made via paracentesis revealing an elevated triglyceride level and milky-white appearance. Chylous ascites is often reported as a postoperative complication in surgical procedures, but it has also been documented in cases of cirrhosis, malignancy, and tuberculosis. However, chylous ascites is rarely seen in chronic pancreatitis and non-cirrhotic portal hypertension. This report presents the case of a 65-year-old man with a history of necrotizing pancreatitis and portal hypertension amidst an incidental finding of chylous ascites upon elective umbilical hernia repair. CASE REPORT We present the case of a patient with chylous ascites discovered during hernia repair. A 65-year-old man with no alcohol or tobacco use and a history of recurrent episodes of acute necrotizing pancreatitis was admitted for umbilical hernia repair. However, upon entering the abdominal cavity, an enlarging mass of ascitic fluid was encountered and tracked into the hernia sac. The fluid was drained via paracentesis and cytology revealed chylous ascites. The patient was discharged in stable condition and was advised to consume a high-protein, low-fat diet. Postoperative computed topography (CT) demonstrated an unchanged necrotic mass in the head of the pancreas. CONCLUSIONS This report demonstrates that when dealing with unexpected findings, it is important to consider the existence of multiple pathologies as the driving cause. We describe a complex cause of chylous ascites, along with a review of the literature on the relationship between chylous ascites and chronic pancreatitis.
The invention discloses a glucosamine chondroitin collagen tablet which comprises raw materials and auxiliary materials. The raw materials contain the following ingredients, by weight, 175-185 parts of D-glucosamine hydrochloride, 195-205 parts of calcium carbonate, 80-90 parts of chondroitin sulfate, 55-65 parts of collagen and 0.4-0.5 part of vitamin D3. The auxiliary materials contain starch and magnesium stearate, and the total weight of the auxiliary materials is 170-180 parts. The invention also discloses a preparation method of the glucosamine chondroitin collagen tablet. The preparation method comprises steps as follows: receiving of raw materials, feeding, crushing, sieving, weighing, mixing, preparation of a soft material, pelletizing, drying, particle shaping, total blending, tabletting and the like. The glucosamine chondroitin collagen tablet provided by the invention is prepared by a scientific technological method according to a certain weight ratio. By the use of the glucosamine chondroitin collagen tablet, osteoporosis can be prevented and treated safely and effectively, and bone mineral density can be increased.
BACKGROUND: Clinical T4 (cT4) stage gastric cancer presents with frequent postoperative recurrence and poor prognosis. This study is to evaluate the oncological efficacy of laparoscopic radical total gastrectomy combined with postoperative prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with cT4N + M0 gastric cancer who received neoadjuvant chemotherapy.
METHODS: We reviewed the clinicopathological data of 174 patients with clinical T4 gastric cancer who underwent neoadjuvant chemotherapy followed by laparoscopic radical total gastrectomy between June 2017 and December 2021. Among them, 142 were included in the non-HIPEC group, and 32 in the HIPEC group. Patients in both groups were paired based on propensity score in a 2:1 ratio to assess disparities in tumor recurrence and long-term survival.
RESULTS: After matching, there were no significant differences in the clinicopathological data between the two groups. The peritoneum (16.1%) and distant organs (10.9%) were the most frequent locations for recurrence. Prior to matching, the recurrence rates were similar at all sites for both groups. Compared with those in the non-HIPEC cohort, the recurrence rates at all sites, the lung, and the peritoneum were notably lower in the HIPEC cohort. Prior to matching, the 3-year overall survival and disease-free survival rates were similar between the two groups; following matching, the HIPEC group exhibited notably greater survival rates than did the non-HIPEC group. The disparities in survival rates between the groups became even more pronounced after conducting a stratified analysis among patients with stage III disease.
CONCLUSIONS: Neoadjuvant chemotherapy combined with prophylactic HIPEC after laparoscopic radical gastrectomy can effectively reduce the rate of peritoneal metastasis in patients with cT4N + M0 advanced gastric cancer and significantly improve the prognosis of such patients, which is of great clinical value.
A composition and its method of preparation that is suitable for vegetarians, providing calcium supplementation as well as gout prevention and treatment. The composition offers functionalities such as calcium replenishment, bones strengthening, and osteoarthritis relief and treatment. It is effective in preventing and treating osteoarthritis in various body parts such as the knee, hip, wrist, spine, hand, shoulder, and ankle. The composition is safe and highly effective in replenishing calcium. Besides, it replenishes calcium, prevents calcium deficiency, and treats calcium deficiency diseases. The composition can be fabricated into tablets, plant-based capsules, dispersible tablets, chewable tablets, effervescent tablets, buccal lozenges, or other oral dosage forms. The composition comprises a mixture of calcium L-aspartate, soybean extract, methyl-sulfonyl-methane (MSM), lecithin, and any one or a combination of  Sambucus williamsii  Hance and Diynaria fortunei (Kunze) J. Sm. The composition may further comprise  Morinda officinalis  extract,  Epimedium grandiflorum  extract, and turmeric root extract. The mixture is sieved and formulated into a dosage form with 0.10g to 1.50g of the mixture per plant-based capsule. As compared to the prior art, the present invention offers advantages such as simple processing method, explicit functional components, and minimal side effects. The composition helps in preventing gout and relieving knee joint pain.
A system and method for securing authenticated patient communication through a device that is able to trigger a patient related event through a simple online communication process. The trigger(s) determined by the device are preferably controlled through a separate application, which may be controlled through a medical user computational device and/or a server. The separate application sets the one or more triggers accessible to the device and also determines one or more conditions for activating the one or more triggers. Upon detection of one or more conditions by the device, one or more triggers are activated. The medical user computational device receives a notification of the activation of the trigger. The medical user computational device may modify the trigger, the activation of the trigger or the one or more downstream actions which occur upon activation of the trigger. Such modification may occur before activation of the trigger or after activation of the trigger. The trigger causes a patient related action to be taken, for example to call the patient back on a separate telephonic device. Preferably the device features a plurality of buttons or other simple, easy to use initiators. Each initiator preferably activates a trigger.
The present invention relates to the administration of an effective amount of Turmeric for corona virus—The sticky turmeric syrup products with benefit use as the trap for all virus. Whiten Turmeric products are safety use treatment for many cases of chronic infection on skin and wherein at many deep areas inside the eye, ear, nose, throat, king and organs, etc. . . . . Combine oral, topical and inhale of effective whiten turmeric products for all infection issues. They can stay at the wet gland and infection area very well. Work for many chronic infections with medic method treatment technique plan and program step to step. The sticky ingredients help to trap all kind in their track then process to collect them into a group as the waste or body trash in 20 days. Then process push these out the body by detox detoxing steps. This treatment experiences look so simply but it works as miracle for many disease and chronic infection in 20 years. It is not much different if we have the Covid-19, corona virus will be getting in the trap and have the same process to get out the body as all bacteria and virus were experience in 20 years. The simple way for the treatment, protection and prevention for deadly corona virus and as a food supplement to promote health and vitality.
Primary tumors of the spine are exceedingly rare and therefore the literature has been limited to case series of limited size and significant heterogeneity. These tumors comprise 11% of all Primary Musculoskeletal Tumors and 4.2% of all spine tumors. Of all primary spine tumors only 6% are malignant, but it is the malignant tumors that present the greatest therapeutic challenges. Through this multi-center retrospective cohort study performed at 13 spine oncology referral, data on at least 2.000 patients with specific primary benign and malignant spine tumors will be collected. This will provide power to determine the influence of many previously hypothesized variables on outcome.

The purpose of this study is to determine clinical, imaging and treatment factors that influence patient survival, local recurrence rate, and peri-operative/post-operative morbidity. Most surgical options carry significant morbidity and consume vast resources. In contrast, there is emerging evidence that incomplete or oncologically inappropriate resection increases local recurrence rate and decreases overall survival. These data will be used to refine existing study questions regarding patient outcomes and to develop new study questions that will be assessed in the future using prospectively collected data.
A method of promoting the health of a user is provided. The method includes obtaining input from a user through the use of a website that is health related. Participation points are assigned for the user based upon the input obtained from the user. The participation points may be pooled with participation points of additional users. A participation point may be selected from the pool of participation points. The selected participation point is linked to a user such that a user is selected.
BACKGROUND: Health and education are interrelated and influence social, economic and lifestyle perspectives. Children with chronic illnesses experience barriers in the educational system regarding school attendance and social isolation. Gaining knowledge of compulsory education and how children with chronic illnesses are supported is crucial for the implications of future education policy and legislation in Scandinavia. This study compares Scandinavian legislation frameworks on compulsory education, chronic illness and school absence to form the basis of future research on education for children with chronic illness.
METHODS: The study uses a comparative approach to explore the support of children with chronic illnesses in compulsory education across Norway, Sweden and Denmark. The documents included are 3 education acts and 15 secondary documents, which are notes and guidelines for the education acts. The data were analysed using a manifest content analysis.
FINDINGS: We found four categories and six subcategories: (1) school obligation and rights; (2) chronic illness; (3) school absence: (a) categorisation of absence; (b) registration of absence; and (c) sanction; and (4) education support: (a) Hospital school support; (b) Home instruction support; and (c) technological support.
CONCLUSION: This study's findings demonstrate the similarities and differences in the Scandinavian compulsory education legislation and guidelines regarding chronic illness and school absence. We found similarities across the countries regarding chronic illness and school absence. Still, the findings showed differences in the systematic registration of school absence and requirements for attendance with compulsory education in Norway and Denmark compared with compulsory schooling in Sweden. This knowledge will inform and enlighten future discussions and decisions in education and public health. The results can contribute to awareness of the opportunities for educational support and perspectives about education for children with chronic illnesses. Future research focusing on the experience of children with chronic illness and educational support is needed.
First, the AMBU Aura-I LMA will be inserted. Then, the patient will be intubated with assistance of the AMBU aScope 2 disposable fiberoptic system.
Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects. Tremor, choreiform movements, mental aberrations, and convulsions may occur rarely. These have occurred most often when large doses of Mecamylamine HCl were used, especially in patients with cerebral or renal insufficiency.

When ganglion blockers or other potent antihypertensive drugs are discontinued suddenly, hypertensive levels return. In patients with malignant hypertension and others, this may occur abruptly and may cause fatal cerebral vascular accidents or acute congestive heart failure. When Mecamylamine HCl is withdrawn, this should be done gradually and other antihypertensive therapy usually must be substituted.

On the other hand, the effects of Mecamylamine HCl sometimes may last from hours to days after therapy is discontinued.
The identification and subsequent management of amblyopia are major consumers of health service resource, and within the hospital sector account for around 80-90% of visits to the children's eye service. Occlusion of the better eye is the mainstay of treatment and because we have little understanding of the dose-response relationship this may continue for many months and sometimes for many hundreds of hours. This is demanding for the child and family as a whole and yet the outcome is frequently unsatisfactory. Currently, there is no reliable data on the kinetics of visual improvement, so occlusion tends to be prescribed on an ad hoc basis. Recent pilot research has shown that 75% of the treatment-generated improvement occurs within the first 4 weeks when 6 hours/day occlusion is prescribed.

In this study we explore the possibility that by intensive treatment the period of amblyopia therapy can be shortened - i.e. made both more efficient and hopefully more effective. The purpose of the present study, the Randomized Occlusion Treatment of Amblyopia Study (ROTAS), is to compare two frequently employed patching regimens: 'substantial' (6 hrs/day) against 'maximal' (12 hrs/day) patching. Our experimental design incorporates objective occlusion monitoring and is able to discriminate the beneficial effect of refractive correction from that of occlusion. The study comprises three phases: 'baseline', 'refractive adaptation' and 'occlusion.' Our aim is to provide guidelines for patient management based, for the first time, on experimentally determined and statistically verifiable relationships between treatment and outcome.
The present invention relates to a kind of Chinese medicine preparation and preparation method for improving body immunity, it is made by the following method：A. culture medium mixed liquor is prepared；B. sterilization treatment；C. cool down；D. it is inoculated with：Zymotic fluid is made；C. stewing process is made with the Chinese medicine preparation for improving body immunity.The present invention improves the Chinese medicine preparation of body immunity, internal micro-ecological environment can be improved, balance conditioning intestinal beneficial flora, various active biology enzyme, amino acid, nucleic acid and trace element etc. in damaged cell added body is repaired, improve immunity, the prevention disease of human body.Meanwhile it is alkalescent constitution that can improve acidic constitution.It can be used for preparing a variety of formulations such as pill, paste, aqua, there is good auxiliary therapeutic action to improving body immunity.
Impaired Hepatic Function: may diminish metabolism of labetalol.

Following Coronary Artery Bypass Surgery: In one uncontrolled study, patients with low cardiac indices and elevated systemic vascular resistance following intravenous labetalol experienced significant declines in cardiac output with little change in systemic vascular resistance. One of these patients developed hypotension following labetalol treatment. Therefore, use of labetalol should be avoided in such patients. 

High-Dose Labetalol: Administration of up to 3 g/d as an infusion for up to 2 to 3 days has been anecdotally reported; several patients experienced hypotension or bradycardia (see DOSAGE AND ADMINISTRATION).

Hypotension: Symptomatic postural hypotension (incidence 58%) is likely to occur if patients are tilted or allowed to assume the upright position within 3 hours of receiving labetalol injection. Therefore, the patient's ability to tolerate an upright position should be established before permitting any ambulation.

Jaundice or Hepatic Dysfunction: (see WARNINGS).
Purpose: Specialized pressure transducers for arterial pulse waveform analysis (S-APWA) devices are dedicated kits connected to an arterial pressure catheter that monitors hemodynamic parameters, such as cardiac output, pulse pressure variation, and stroke volume variation, less invasively. While the association between the use of S-APWA devices and clinical outcomes in perioperative patients has been previously evaluated, its assessment in patients with septic shock remains inadequate. Materials and Methods: This retrospective cohort study utilized a nationwide Diagnosis Procedure Combination database in Japan. Adult patients with septic shock admitted to the intensive care unit (ICU) with arterial pressure catheter placement on the admission day from August 2012 to February 2021 were included. Hospitalizations meeting the eligibility criteria were categorized into groups based on S-APWA device usage. The primary outcome, evaluated using Cox regression analysis, was 30-day all-cause mortality in the propensity score overlap-weighted population. Secondary outcomes included in-hospital mortality, ICU duration, and overall hospital stay. Results: Among 5130 eligible hospitalizations, 643 were in the S-APWA group and 4487 were in the conventional pressure transducer group. Cox regression analysis within the propensity score overlap-weighted population showed no significant difference in 30-day mortality (adjusted hazard ratio: 0.94; 95% confidence interval: 0.9-1.38; P = .58). Logistic regression analysis indicated no significant differences in the in-hospital mortality. While the S-APWA group had prolonged ICU stays, no significant difference in the overall hospital stay was observed according to linear regression analyses. Conclusions: Our study found no significant association between S-APWA use and 30-day mortality in patients with septic shock. These findings offer insights into optimizing monitoring systems in ICUs.
Ciclesonide, is a prodrug, that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1) following oral inhalation. Des-ciclesonide has anti-inflammatory activity with affinity for glucocorticoid receptors that is 120 times greater than the parent compound and 12 times greater than dexamethasone. The clinical significance of these findings is unknown. 

The precise mechanisms of corticosteroid action in asthma are unknown. Inflammation is recognized as an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of inhibitory activities against multiple cell types (e.g., mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in the asthmatic response. These anti-inflammatory actions of corticosteroids may contribute to their efficacy in asthma. Though effective for the treatment of asthma, corticosteroids do not affect asthma symptoms immediately. Individual patients will experience a variable time to onset and degree of symptom relief. Maximum benefit may not be achieved for four weeks or longer after starting treatment. When corticosteroids are discontinued, asthma stability may persist for several days or longer.