anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This arm receives wearable device and mobile application-supported nutritional counseling for four months. The nutritional counseling consists of both calorie restriction (500kcal below estimated energy requirement) and time-restricted eating (an 8-hour period (from 10 a.m. to 6 p.m.) each day).
Disclosed is a method performed in a health study management system for configuring the collection of health-related data from a plurality of user devices associated with participants in a health study. The health-related data may comprise one or more of: data indicative of user health, and source data from which data indicative of user health can be derived. The method comprises maintaining in a database a catalogue of predefined data collection activities, each data collection activity performable at user devices for obtaining health-related data. A health study configuration for a health study is received, the health study configuration identifying a selected group of data collection activities from the catalogue, each of the group of data collection activities for acquiring respective health-related data for the health study. Based on the catalogue and the selected group of data collection activities, a data collection configuration is generated for each of a plurality of user devices associated with study participants, the data collection configuration specifying the data collection activities to be performed at a user device. The generated data collection configuration is transmitted to each user device to configure the user device to perform the specified data collection activities.
The first component is stem cell transplant. Goal is to administer more than 3 x 106 CD34+ cells/kg of peripheral blood progenitor cells (PBPC). The second component is the planned DLI infusion. iCasp9 (BPZ-1001)-Modified T-cells) of 3 X 10\^6/kg in 100 ml infused over approximately a one hour period between Day + 56 to Day +64. The transplant day is referred to as day zero (D0), treatment plan activities prior or after D0 are denoted as day minus (D-) or day plus (D+). Patients receive standard reduced intensity regimen using fludarabine, melphalan, and alemtuzumab to achieve engraftment with a low risk of GVHD. At approximately 60 days post transplant patients who are alive and without GVHD, receive DLI to enhance graft-vs.-malignancy and immune reconstitution.
Recruitment of twenty depressive subjects will be conducted within the hospital service adult psychiatry.These patients are referred for indication of ECT sessions for severe resistant depression. Four MRI evaluations (3T MRI examination) are programmed in such patients to analyze structural changes in the hippocampus.
The management of cardiogenic shock is an ongoing challenge. Despite all efforts and tremendous use of resources, mortality remains high. Whilst reversing the underlying cause, restoring/maintaining organ perfusion and function are cornerstones of management. The presence of comorbidities and preexisting organ dysfunction increases management complexity, aiming to integrate the needs of vital organs in each individual patient. This review provides a comprehensive overview of contemporary literature regarding the definition and classification of cardiogenic shock, its pathophysiology, diagnosis, laboratory evaluation, and monitoring. Further, we distill the latest evidence in pharmacologic therapy and the use of mechanical circulatory support including recently published randomized-controlled trials as well as future directions of research, integrating this within an international group of authors to provide a global perspective. Finally, we explore the need for individualization, especially in the face of neutral randomized trials which may be related to a dilution of a potential benefit of an intervention (i.e., average effect) in this heterogeneous clinical syndrome, including the use of novel biomarkers, artificial intelligence, and machine learning approaches to identify specific endotypes of cardiogenic shock (i.e., subclasses with distinct underlying biological/molecular mechanisms) to support a more personalized medicine beyond the syndromic approach of cardiogenic shock.
Tetracaine Hydrochloride Ophthalmic Solution 0.5% STERI-UNITS® is supplied as single patient use, 4 mL filled in 4-mL natural medium- or low-density polyethylene plastic DROP-TAINER® dispensers and natural low-density polyethylene tips with white polypropylene caps in a carton of 12. Each sterilized DROP-TAINER® dispenser is packaged in a clear PVC and Tyvek blister. This product does not contain a preservative; discard unused portion.

NDC 0065-0741-14   
Storage: Store at 2°C to 25°C (36°F to 77°F). Protect from light. Do not use if solution contains crystals, is cloudy, or discolored.
COVID-19 is an emergency situation which broke out from China in 2020. Health commitees and goverment set some rules and limit people's freedom to leave from their houses and it is called as 'social isolation'. With social isolation people were restricted to go outside from house and with that they had to stay at home. Staying at home and disease bring about sedentary lifestyle, anxiety and depression and changed eating habits of all person. It was very dangerous especially chronically ill persons. Physical activity and exercise are keystones for managing cardiovasculary disease risk factors. Hypertension is important risk factor all around the world. Disease control is important to prevent complications. In that study, we aimed to assess hypertensive and healhty individuals' physical activity, anxiety, healthy lifestyle habits and quality of life with changed life condition during COVID-19 social isolation.
The groups are inverted due to the crossover design, so the previous sham group becomes the active group for Chlorella p consumption after the washout . So, this group must consume 10 tablets per day of Chlorella p for 30 days. (5g/day) and must return within 30 days for evaluation.
The invention discloses a compound feed for chicken and a preparation method of the compound feed for chicken. The compound feed comprises the following raw materials: bran, millet, sesame powder, table salt, shrimp powder, fish powder, bean dregs, rapeseed dregs, soybean meal, mountain flour, a compound enzyme, a vitamin additive, an amino acid additive, beet, choline, calcium hydrogen phosphate, a trace element additive and sorbic acid. The compound feed for chicken further comprises traditional Chinese medicine additives. The preparation method comprises the following steps: a smashing step, a material preparing step, a proportioning step and a drying step. The compound feed for chicken disclosed by the invention has the benefits that the compound feed disclosed by the invention contains the traditional Chinese medicine additives which have the functions of promoting blood circulation to remove blood stasis, relieving swelling and pain, dredging the veins and dispelling cold, warming the blood and promoting granulation and diminishing inflammation and reducing internal heat. Syndrome differentiation and treatment are carried out on the basis of holistic view. The compound feed is relatively strong in target and the efficacy can directly reach the focus, so that the pathogenetic condition is effectively controlled and the curative effect is remarkable. Moreover, as the compound feed is prepared from pure natural traditional Chinese medicines, the compound feed is low in price, safe and effective and free of medicine residues, and can improve the appetite of the chicken and satisfy the nutritional requirements of the chicken.
BACKGROUND: Foreign bodies (FBs) are a common emergency in medical institutions, that can occur in any area and among people of any age, which are common public health problems. Understanding the epidemiological characteristics of FBs is crucial for their prevention and control. The purpose of this study was to analyze the epidemiological characteristics of FBs worldwide through the data from the Global Burden of Disease Study 2019 (GBD 2019).
METHODS: We obtained data from the GBD 2019, which is an important public database to understand the disease burden of FBs. Joinpoint was used to analyze temporal trends in the incidence and death trends of FBs, which is widely used to study the long-term temporal trend of the burden of diseases. SaTScan was used to detect spatial-temporal clusters of pulmonary aspiration and foreign body in the airway (PAFBA), which is based on a Poisson model, scanning the number of people and diseases in the study area to obtain the spatial-temporal clusters of diseases.
RESULTS: Globally, the age-standardized incidence rate (ASIR) and the age-standardized death rate (ASDR) of FBs in 2019 were 869.23/100,000 (679.92/100,000-1120.69/100,000) and 1.55/100,000 (1.41/100,000-1.67/100,000), respectively. The ASIR and ASDR showed downtrends with average annual percent changes (AAPCs) of -0.31% and - 1.47% from 1990 to 2019. Of note, the ASIR showed an uptrend during 2010-2019, especially in high, high-middle, and middle SDI regions. Stratified analysis by age group showed that ASIR increased in each age group in recent years. From 1990 to 2019, the ASDR in the over-70 age group showed an uptrend worldwide, especially in high and high-middle SDI regions. In different types of FBs, the ASDR of PAFBA was the highest. The death burden of PAFBA was mainly clustered in 82 countries during 1993-2007, such as Canada, Cuba, and Mexico.
CONCLUSION: The most important goal is to improve public awareness and emergency knowledge of FBs through publicity methods, such as the internet or offline activities, and to improve laws and regulations. Additionally, different age groups need different targeted measures, such as strengthening the care of children, caring for elderly individuals, improving necessary monitoring programs and reporting systems, conducting effective hazard assessments, and publicity and education activities.
A low pressure aerosol foam composition consists of a vehicle, a surfactant blend and a propellant, said vehicle being a mono-alcohol having one to three carbon atoms in the amount of 30 to 55% and water in sufficient amount in the concentrate to make 100%, said surfactant blend being present in amount of 0.4 to 5.0%, soluble at temperatures of about 6 DEG  C. in said composition being a fatty alcohol having 12 to 22 carbon atoms combined with a non-ionic surfactant which is a polyethylene oxide derivative of said fatty alcohols, fatty acids, lanolin acids or lanolin alcohols, said propellant being present in amounts of 2 to 18%, being butane, monochlordifluoroethane, difluoroethane, trichloromonofluoromethane, dichloromonofluoromethane, dichlorodifluoromethane or tetrafluorodichloroethane, the pressure thereof being 10 to 40 p.s.i.g. at ambient temperatures. Preferred surfactant blends include ethers of sorbitan fatty acid esters and ethoxylated saturated C16- 20 fatty alcohols and ethoxylated lanolin alcohols.  Optional additives include glycerol, polyethylene glycol, di- and tri-ethoxy oleyl ether and tetraethoxy lauryl ether, hexachlorophene, polyvinyl pyrrolidone, guaiazulene, cetyl trimethyl ammonium bromide, menthol, allantoin and perfumes.  Examples are given of aftershave lotions, body fresheners and medicated skin products.ALSO:A low pressure aerosol foam cosmetic composition consists of a vehicle, a surfactant blend and a propellant, said vehicle being a mono-alcohol having one to three carbon atoms in the amount of 30 to 55% and water in sufficient amount in the concentrate to make 100%, said surfactant blend being present in amount of 0.4 to 5.0%, soluble at temperatures of about 6 DEG C. in said composition being a fatty alcohol having 12 to 22 carbon atoms combined with a non-ionic surfactant which is a polyethylene oxide derivative of said fatty alcohols, fatty acids, lanoline acids or lanoline alcohols, said propellant being present in amounts of 2 to 18%, being butane, monochlor difluoroethane, difluoroethane, trichloromonofluoromethane, dichloro monofluoromethane, dichloro difluoromethane or tetrafluoro dichloroethane, the pressure thereof being 10 to 40 p.s.i.g. at ambient temperatures. Preferred surfactant blends include ethers of sorbitan fatty acid esters and ethoxilated saturated C16-20 fatty alcohols and ethoxilated lanoline alcohols.  Optional additives include glycerol, polyethylene glycol, di- and tri-ethoxy oleyl ether and tetraethoxy lauryl ether, hexachlorophene, polyvinyl pyrollidone, guaiazulene, cetyl trimethyl ammonium bromide, menthol, allantoin and perfumes.  Examples are given of after-shave lotions, body fresheners and medicated skin products.
The study will enroll 90 adult subjects with transfusion independent sickle cell disease (70 SS, 10 SC, 10 Sβ0) and 60 patients with transfusion-dependent sickle cell disease. It will also include 10 transfusion independent thalassemia patients and 20 transfusion dependent thalassemia patients. Diamox (acetazolamide) will be administered during MRI.
Participants: Healthy overweight females with BMI \>25 kg/m2 and 25-45 years of age were recruited through advertisements and word of mouth on the campus of the University of Glasgow or from other public places. Participants were required to be sedentary, non-smokers, with stable body weight for two months prior to the study enrollment, not pregnant, free of medication, nutritional supplementation or following any specific diet and with no antibiotic use for the past three months. Participants with chronic illness, eating disorders and history of gastrointestinal operations were excluded.

Study Design: This is a randomized study with a parallel design. Study participants underwent 4 week supervised moderate intensity exercise training combined either with IPE (EX/IPE) or cellulose as placebo (EX/Placebo) supplementation at doses of 10g / day. Supplements were provided as sachets containing white powder and participants were asked to consume one sachet per day with breakfast in a way convenient for each participant. Before the start of the study and at the end of the 4-week intervention, participants were asked to conduct a submaximal exercise test. Prior to the first and after the second submaximal exercise test, participants of both groups conducted a 7-hour experimental trial which involved collection of expired air and blood samples in fasted and postprandial states. Body weight and body composition were measured in the fasted state. Prior to the first 7-hour experimental trial, participants were asked to record their diet for 3 days and replicate this intake prior to the second 7-hour experimental trial.
The effectiveness of ischemic postconditioning (iPoC) in patients with ST-elevation myocardial infarction (STEMI) without ischemic preconditioning has not been determined. Therefore, we investigated the impact of iPoC and its potential mechanism related to heat shock protein 72 (HSP72) induction on myocardial salvage in patients with STEMI without prodromal angina (PA).We retrospectively analyzed data from 102 patients with STEMI with successful reperfusion among 323 consecutive patients with acute coronary syndrome. Among these, 55 patients with iPoC (iPoC (+) ) underwent 4 cycles of 60-second inflation and 30-second deflation of the angioplasty balloon. Both the iPoC (+) and iPoC (-) groups were divided into 2 further subgroups: patients with PA (PA (+) ) and those without (PA (-) ). We analyzed HSP72 levels in neutrophils, which were measured until 48 hours after reperfusion. I-123 β-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) scintigraphy was performed within a week of reperfusion therapy. In 64% of patients, thallium-201 (TL) scintigraphy was performed 6-8 months after STEMI onset.Using BMIPP and TL, in the PA (-) subgroups, the iPoC (+) group had a significantly greater myocardial salvage ratio than the iPoC (-) group. iPoC was identified as an independent predictor of the myocardial salvage ratio. The HSP72 increase ratio was significantly elevated in the iPoC (+) PA (-) group. Importantly, the myocardial salvage effect in patients without PA was significantly correlated with the HSP72 increase ratio, which was greater in patients with iPoC.These results suggest the potential impact of iPoC via HSP72 induction on myocardial salvage; however, the effects may be limited to patients with STEMI without PA.
Autophagy is central to the benefits of longevity signaling programs and to hematopoietic stem cell (HSC) response to nutrient stress. With age, a subset of HSCs increases autophagy flux and preserves regenerative capacity, but the signals triggering autophagy and maintaining the functionality of autophagy-activated old HSCs (oHSCs) remain unknown. Here, we demonstrate that autophagy is an adaptive cytoprotective response to chronic inflammation in the aging murine bone marrow (BM) niche. We find that inflammation impairs glucose uptake and suppresses glycolysis in oHSCs through Socs3-mediated inhibition of AKT/FoxO-dependent signaling, with inflammation-mediated autophagy engagement preserving functional quiescence by enabling metabolic adaptation to glycolytic impairment. Moreover, we show that transient autophagy induction via a short-term fasting/refeeding paradigm normalizes glycolytic flux and significantly boosts oHSC regenerative potential. Our results identify inflammation-driven glucose hypometabolism as a key driver of HSC dysfunction with age and establish autophagy as a targetable node to reset oHSC regenerative capacity.
The invention relates to a medicine for treating endometriosis, in particular to a Chinese medicine oral decoction for treating endometriosis, which is prepared by using Chinese herbal medicines as raw materials. The invention adopts the technical scheme that the Chinese medicine oral decoction comprises the following raw medicinal materials in parts by weight: 4-12g of bupleurum, 4-12g of salvia miltiorrhiza, 4-12g of achyranthes, 5-15g of red paeony roots, 5-15g of pollen typhae, 5-15g of hemlock parsley, 5-15g of barbary wolfberry fruits, 5-15g of herba epimedii and 5-15g of Chinese dodder seeds. In the invention, all the raw medicinal materials are reasonably mixed to achieve the efficacies of promoting blood circulation and removing blood stasis, clearing heat and detoxicating, relieving stasis and stopping pain, removing heat from the blood and dispersing swelling, calming the mind, relaxing bowel, and the like. By oral administration, the Chinese medicine oral decoction can regulate inner body, strengthen the body resistance to consolidate the constitution, regulate endocrine disturbance, enhance immune functions of human bodies, balance yin and yang, restore the Zang-Fu functions in dynamic balance, and effectively treat endometriosis. The invention has the advantages of no side effect, economy, practicability and simple method, and can be prepared independently. The invention is applicable to patients with slight endometriosis accompanied with luteal insufficiency or ovulation failure.
Needles will be inserted at 11 acupoints. Acupoints will be added electrical stimulation via a low-frequency neural regulator (electrical stimulator) respectively with a disperse-dense wave after insertion of all needles. Twenty-minute treatments will be delivered three times weekly for 8 weeks.
PURPOSE:To impart excellent safety for the skin and surface activity to the surfactant by synthesizing a surfactant consisting of the phosphoric ester of an alkyl glycoside expressed by a specified general formula. CONSTITUTION:Specified amts. of phosphorus pentoxide and water are added to a soln. of an alkyl glycoside in tetrahydrofuran, agitated at room temp. and uniformly dissolved, and the soln. is refluxed and agitated. Water is added after reaction to cause hydrolysis, and the surfactant is extracted with chloroform. A surfactant consisting of the phosphoric ester of an alkyl glycoside expressed by formula I (where R is 10-18C alkyls) is obtained in this way. The obtained ester is excellent in lowering surface tension and in foaming ability, and applied to the ordinary detergent such as a kitchen cleanser. Besides, a 10-14C alkyl group is especially appropriate for shampoo such as conditioning shampoo, hair treatment and body shampoo.
AIM: To investigate the effect of instrument-assisted soft tissue mobilization technique on pain, joint range of motion, functionality and quality of life in patients with lumbar disc herniation.
METHODS: This is a double blinded, randomized controlled trial. A total of 60 patients were randomly allocated to either an experimental group [n = 30, age = 46.33 ± 12.96 years] or a control group [n = 30, age = 57.03 ± 9.64 years]. The experimental group received instrument-assisted soft tissue mobilization [3 consecutive days a week for 4 weeks] in addition to conventional physiotherapy [five days a week for 4 weeks]. The control group only received the conventional physiotherapy [five days a week for 4 weeks]. Pain intensity, range of motion of the lumbar spine (flexion, extension, lateral flexion), functional disability related to low back pain and quality of life were assessed at the beginning and end of the study.
RESULTS: The experimental group showed statistically significant improvements in the range of motion in lumbar area (flexion, extension and lateral flexion values) compared to that shown in the control group (p < 0.05). The mean differences in Oswestry disability index were significantly better in experimental group than in the control group (p < 0.05). There were no significant differences between the two groups in terms of pain and quality of life (p > 0.05).
CONCLUSIONS: Instrument-assisted soft tissue mobilization, in addition to conservative treatment, can improve range of motion in lumbar area and reduce functional disability in patients with Lumbar Region Disc Herniations.
Interrogation of the exhaled breath metabolome will be performed by using an objective method of measurement for placebo effects in pain analgesia, known as Cold Pressure Test (CPT). CPT reactions can be measured objectively by blood pressure spikes as well as changes in continuous heart rate monitoring.To this end, probands will be continuously connected to a Heartrate \& Blood Pressure Monitor. First, baseline exhalation will be assessed. Then, the CPT is performed according to the 'CPT Guide' with subsequent post-pain exhalations analysis with or without self-administration of the placebo (NaCl nasal spray). After 15 minutes rest, probands will be submitted to a second post-pain exhalations set (+/- placebo). The process is completely non-invasive as the participant just exhales through a commercially available disposable bacterial/viral filter coupled to the ion source.