anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Uric acid (UA) is the most powerful antioxidant found among human body fluids. With this effect, UA protects neurons from oxidant effects and ensures the continuation of the structure and functions of neuronal tissue. However, UA has effects on the immune system. This study aims to explain the relationship between UA, cognitive level and inflammation in cases with a wide spectrum of cognitive function.
METHODS: A total of 67 women and 62 men who applied to the psychiatry outpatient clinic to obtain a health report were evaluated. The cognitive states of the individuals were determined with the mini-mental state examination test (MMSE). Additionally, serum uric acid levels and simple inflammatory parameters such as CRP, sedimentation, neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were measured. According to the MMSE results, two groups were created. Those with an MMSE score of 24 or above formed the first group, and those with an MMSE score below 24 formed the second group.
RESULTS: While a statistically significant positive strong correlation was found between UA and MMSE in all individuals, negative correlations were found between UA and NLR and MLR in men. UA was found to be significantly lower in the group with MMSE scores below 24 and NLR values were higher in the same group.
CONCLUSION: According to these results, UA seems to have a protective effect on cognitive functions. This situation manifests itself more clearly in men. At physiological concentrations, UA may have an anti-inflammatory effect. It appears that there are complex interactions between UA, cognition, and inflammation. Particularly, men appear to be more susceptible to UA effects.
Lorlatinib 100mg once daily. Carboplatin AUC 5 or Cisplatin 75 mg/m\^2 for an induction phase of four cycles. Pemetrexed 500 mg/m\^2 during the maintenance phase.
Oxygen deficiency is a major problem in the Baltic Sea. To study the impact of hypoxia on the functional diversity of benthic fauna and the possibility of macrozoobenthos recovery, data were analyzed in a gradient of oxygen conditions in the Gdańsk Basin. The research conducted on the basis of biological traits analysis enabled us to analyze the number, type and spatial distribution of biological traits-a proxy for functions performed by macrozoobenthos. A significant depletion of macrofauna was already observed under conditions of reduced oxygen above the bottom, both in terms of functional diversity and biomass. Although taxa observed in hypoxia (DO < 2 mL L-1) perform a number of functions, the remaining species do not form complex structures in the sediments or cause deep bioturbation and bioirrigation. Moreover, their extremely low biomass plays an irrelevant role in benthic-pelagic coupling. Thus, benthic fauna under hypoxia is not an element that ensures the functioning of the ecosystem. We assess that traits important for species dispersal and the presence of taxa resistant to short-term hypoxia in the oxic zone above the halocline provide a "backup" for ecosystem functioning under altered diverse oxygen conditions below the halocline after cessation of hypoxia in the southern Baltic Sea.
OBJECTIVES: Undertreated pediatric postsurgical pain negatively affects health-related quality of life (HRQOL) and functioning and may lead to chronic postsurgical pain (CPSP). Predictors of recovery have been identified but more research is needed, particularly regarding resilience, social factors, and long-term effects. The aim of the present study was to investigate child and parent risk and resilience factors as predictors of long-term postsurgical recovery for adolescents.
METHODS: Participants were patients with Adolescent Idiopathic Scoliosis (AIS), 12 to 18 years old, undergoing spinal fusion, and their parents. Recruitment occurred at the orthopedic units at 4 hospitals in Belgium. Data were collected before surgery (T0), at 3 (T1) and 6 weeks (T2), 6 months (T3), and 1 year (T4) post surgery. Multiple regression models were used to evaluate the predictive effect of pain intensity, pain catastrophizing, psychological flexibility, and pain acceptance on long-term functioning, HRQOL, and pain.
RESULTS: The sample comprised 100 adolescents and 61 parents. Pain at T0, T1, and T3 and adolescent pain catastrophizing (T0) predicted health-related quality of life, functioning, and pain at T4 (while pain at T2 predicted HRQOL and pain). Parent pain catastrophizing predicted pain at T4. Adolescent and parental psychological flexibility predicted HRQOL, and parent psychological flexibility also predicted pain at T4. Adolescent acceptance at T1 predicted pain, and acceptance at T2 predicted HRQOL, at T4.
DISCUSSION: The study identified pain and adolescent pain catastrophizing as risk factors, and adolescent and parental psychological flexibility and adolescent pain acceptance as resilience factors, for long-term recovery in youths undergoing spinal fusion. Postsurgical pain management targeting these factors may therefore promote recovery for these adolescents.
The invention discloses a traditional Chinese medicine lotion for treating psoriasis. The traditional Chinese medicine lotion belongs to the pharmaceutical field. The traditional Chinese medicine lotion is prepared by a stewing process with honeycomb, folium artemisiae argyi, acorus calamus, cortex phellodendri, herba schizonepetae, radix sophorae flavescentis, saposhnicovia divaricata, radix angelicae, realgar, broussonetia papeyrifera, christina loosestrife herb, galla chinensis, rhizoma smilacis glabrae, wild chrysanthemum flower, fructus kochiae, liquidambar formosana hance, fructus cnidii, fructus xanthii and tribulus terrestris as raw materials. The traditional Chinese medicine lotion is used for medicated bath of psoriasis; medicine can be absorbed through skin surface during the medicated bath. High concentration medicine active ingredients permeate the outside of cuticular cell membranes, folliculus pili, glandula sebacea, sweat duct orifices and the like gently and uniformly, and enter the body rapidly through systemic capillaries from the outside to the inside. The traditional Chinese medicine lotion has good effects for regulating of qi and blood, balancing yin and yang, dredging channels and collaterals, warming channels and expelling cold, dispelling wind and eliminating dampness, clearing heat and removing toxicity, reducing swelling and removing stasis, dredging collaterals and relieving itching, nourishing and promoting tissue regeneration, and detoxifying to remove spots.
Disseminated head and neck cancer is a serious, often life-threatening medical problem that requires immediate and heroic therapeutic intervention. Treatment typically begins with extensive surgery followed as soon as possible by an intense series of radiation and chemotherapy treatments. Typically the patient has recovered sufficiently from the surgery by 2-4 weeks to withstand the new assaults that will result from chemoradiation therapy (CRT), which kills cancer cells, but also causes muscle atrophy and scarring that can permanently ruin the swallowing apparatus. Thus, the majority of patients who undergo CRT develop severe swallowing problems, called dysphagia, that typically becomes worse by about 3-4 weeks following the beginning of CRT. In anticipation of all of these problems, subjects have a tube placed in the stomach (gastrostomy tube) so that they can be fed through the tube in the immediate postoperative period when the incision is fragile and when dysphagia develops during CRT. Clearly the management of dysphagia during CRT is of primary importance to the prognosis of the patient. Recent studies have shown that electrical activation of swallowing muscles during and after CRT can improve the prognosis by reducing dysphagia, but currently available technology requires the current to be applied transcutaneously. Thus, large electrical currents must be applied to the damaged skin, and the electrical stimulation that results is uncomfortable, diffuse and uncontrolled. It is difficult with this approach to stimulate the deepest muscles that are the preferred targets for the stimulation. The primary goal of the proposed study is to improve the long-term swallowing capabilities of subjects undergoing radical or modified radical neck surgeries followed by CRT, by more selective stimulation of the swallowing muscles using implanted microstimulators called BIONs. The mechanism of the electrical stimulation is thought to be the same as that for other rehabilitative approaches to muscle, i.e.,to help maintain strength and mobility of these muscles during the post-operative treatment period when the muscles are not being used and are particularly vulnerable to scarring and atrophy.

Two different paradigms of stimulation will be employed in order to compare and gain insight into the mechanisms involved in the remediation. This study also presents the opportunity to examine directly the changes in muscle produced by stimulation. Thus, a secondary research goal of the study that takes advantage of the opportunity presented by this intervention is to gain insight into the cellular changes that are thought to underlie the effects of radiation and subsequent electrical stimulation. By implanting these devices at the time of the neck surgeries, it is possible to target the nerves that supply specific muscles and thus ensure the excitation of specific muscles using current strengths much lower than those required with transcutaneous stimulation.
PA will be administered once daily according to body weight: granule ( 60 mg pyronaridine + 20 artesunate), one in children 5 \< 7kg, two in children 8 \< 15kg and three in children 15 \< 20kg. Tablets ( 180 mg pyronaridine+ 60 mg artesunate), one in children 20 \< 24Kg and two in children 24 \< 45Kg.
In two double-blind, vehicle-controlled clinical studies, 436 subjects with AK were randomized to treatment with either Imiquimod Cream or vehicle cream 2 times per week for 16 weeks. The studies enrolled subjects with 4 to 8 clinically typical, visible, discrete, nonhyperkeratotic, nonhypertrophic AK lesions within a 25 cm2 contiguous treatment area on either the face or scalp. The 25 cm2 contiguous treatment area could be of any dimensions e.g., 5 cm × 5 cm, 3 cm by 8.3 cm, 2 cm by 12.5 cm. Study subjects ranged from 37 to 88 years of age (median 66 years) and 55% had Fitzpatrick skin type I or II. All Imiquimod-treated subjects were Caucasians.

On a scheduled dosing day, the study cream was applied to the entire treatment area prior to normal sleeping hours and left on for approximately 8 hours. Twice weekly dosing was continued for a total of 16 weeks. The clinical response of each subject was evaluated 8 weeks after the last scheduled application of study cream. Efficacy was assessed by the complete clearance rate, defined as the proportion of subjects at the 8-week post-treatment visit with no (zero) clinically visible AK lesions in the treatment area. Complete clearance included clearance of all baseline lesions, as well as any new or sub-clinical AK lesions which appeared during therapy.

Complete and partial clearance rates are shown in the table below. The partial clearance rate was defined as the percentage of subjects in whom 75% or more baseline AK lesions were cleared.

Sub-clinical AK lesions may become apparent in the treatment area during treatment with Imiquimod Cream. During the course of treatment, 48% (103/215) of subjects experienced an increase in AK lesions relative to the number present at baseline within the treatment area. Subjects with an increase in AK lesions had a similar response to those with no increase in AK lesions.
Aim: To assess the effectiveness of implementing evidence-based recommendations using a continuous quality improvement cycle model on patient outcomes and healthcare quality. Design: Quasi-experimental, multicentre, before-and-after. Methods: NHS units and Nursing Homes, patients attended by them and professionals implementing the recommendations. Intervention: implementation of evidence-based recommendation with a continuous quality improvement cycle's model (process of improvement by reference to a prior baseline clinical audit). Variables: Process and outcome criteria with respect to assessment and management of pain, management of urinary incontinence, prevention of child obesity, promotion of breastfeeding, promotion of hand hygiene, competencies in evidence-based practice, barriers to the implementation and strategies for overcoming them. Data will be collected at baseline and, during the first year of follow-up, at months 3, 6 and 12, with data on patients and indicators being drawn from clinical histories and records. Descriptive analysis and comparison of the effectiveness of the intervention by means of inferential analysis and analysis of trends across follow-up. 95% confidence level. This project is partially funded by The Spanish Centre for Evidence Based Nursing and Healthcare. Project duration 2022-2024.

This project is a second edition of The SUMAMOS EXCELENCIA Project: Assessment of Implementation of Best Practices in a National Health System (NCT03725774), with a similar design but with changes in some of the themes.
Background and Purpose: Conventional rehabilitation does not restore normal, upper limb function or normal gait to many stroke survivors. Functional neuromuscular stimulation (FNS) has shown promise for functional enhancement of both upper and lower limb motor control following stroke. Gains included muscle activation latencies, strength, coordination, upper limb functional tasks, gait kinematics, walking endurance, and quality of life. The purpose of the proposed work is to test the radio frequency-controlled (RF) Microstimulator (RFM) Gait System regarding system performance and subject response to treatment.

Methods: This is a feasibility study in which up to four subjects will receive the (RFM) Gait System. Up to ten RFMs will be placed for a given subject. An RFM ankle muscle system will be used to train ankle gait components. A separate RFM system will be used to train knee gait components. Subjects will be treated for 6 months, four sessions/wk. Primary outcome measures for the RFM Gait System will be: kinematic swing phase gait components and walking endurance. Secondary outcome measures will include: strength, coordination, spasticity, function, and quality of life. Data collections will occur at months 1, 3 and 6, and for follow-up times up to a year after the end of treatment. The results of the RFM ankle system have the potential to provide a new technology for ankle muscle gait components.
Primary care patients with a current COPD diagnosis who visit the GP team for their COPD are eligible to participate in the study. Patients with COPD will be recruited from 10-15 primary care practices in the Netherlands. The population includes men and women ≥35 years of age with clinically diagnosed COPD. The diagnosis of COPD is allowed to be a clinical diagnosis rendered by a member of the GP team, without the requirement to conduct additional confirm- atory testing. Furthermore, a limited number of in- and exclusion criteria will be adopted, to make sure the research population closely resembles the real world.
The invention provides an evaluation device for cerebral dysfunction with the capability of adjusting the prompt cycle of a task for body motion based on individual differences. The evaluation device comprises a body motion prompt unit, a body motion detection unit, an operation input unit, an output unit, a storage unit and a data processing unit. The body motion prompt unit is used for prompting the task for body motion to a person to be tested. The body motion detection unit is used for detecting data of body motion of the person to be tested. The operation input unit is used for receiving inputted information. The output unit is used for outputting information to the outside. The storage unit is used for storing various data. The data processing unit comprises a body motion task selecting part used for selecting the task for body motion, a data obtaining part used for obtaining various data, an indication data generating part used for generating an indication cycle by accuracy of body motion obtained from information inputted by the operation input unit and from accuracy of body motion calculated by a calculating part for body motion accuracy and then generating indication data by utilization of the above indication cycle, the calculating part for body motion accuracy used for calculating accuracy of body motion and an evaluation part for degree of dysfunction for cognition used for evaluating degree of dysfunction for cognition based on accuracy of body motion.
Opioid-induced constipation (OIC) is a rising problem due to the progressive increase in opioid prescription. In contrast to functional constipation, opioid-induced constipation is not a functional gut disorder but a side effect of opioid use. Opioids produce constipation due to a decrease in gastrointestinal motility and a reduction in gastrointestinal secretions. The treatment of OIC focuses on three basic pillars: optimizing opioid drug indication, preventing constipation onset, and treating constipation should it develop. As with any other cause of constipation, lifestyle adjustments and laxatives should be the first-line option in the pharmacological management of OIC. Osmotic laxatives such as polyethylene glycol (PEG) are the agents of choice. PEG is inert and is neither fermented nor absorbed in the gastrointestinal tract. Furthermore, it has broad clinical applicability due to its favourable safety profile. If first-line treatments fail, peripheral μ-opioid receptor antagonists (PAMORA) are the drugs of choice. They reduce the peripheral effects of OIC with a minimal potential to diminish analgesia or induce a centrally mediated withdrawal syndrome. Different PAMORA are available in the market both for oral and subcutaneous administration, with demonstrated efficacy for the management of OIC in different clinical trials.
Establishment of sterile areas and cleaning of the skin around the knee with a povidone-iodine solution. This was followed by an intraarticular injection containing 4 mL of a bioengineered hyaluronic acid.
INTRODUCTION: Non-coding RNAs (ncRNAs), which are incapable of encoding proteins, are involved in the progression of numerous tumors by altering transcriptional and post-transcriptional processing. Recent studies have revealed prominent features of ncRNAs in pyroptosis, a type of non-apoptotic programmed cellular destruction linked to an inflammatory reaction. Drug resistance has arisen gradually as a result of anti-apoptotic proteins, therefore strategies based on pyroptotic cell death have attracted increasing attention. We have observed that ncRNAs may exert significant influence on cancer therapy, chemotherapy, radio- therapy, targeted therapy and immunotherapy, by regulating pyroptosis.
AREAS COVERED: Literatures were searched (December 2023) for studies on cancer therapy for ncRNAs-mediated pyroptotic cell death.
EXPERT OPINION: The most universal mechanical strategy for ncRNAs to regulate target genes is competitive endogenous RNAs (ceRNA). Besides, certain ncRNAs could directly interact with proteins and modulate downstream genes to induce pyroptosis, resulting in tumor growth or inhibition. In this review, we aim to display that ncRNAs, predominantly long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), could function as potential biomarkers for diagnosis and prognosis and produce new insights into anti-cancer strategies modulated by pyroptosis for clinical applications.
This commercially available program (Noom Weight) promotes clinically significant body weight loss and behavior change in multiple populations including our pilot study in individuals with MASLD. The program is delivered through a smartphone application and includes self-monitoring and feedback features for diet, physical activity, and body weight, as well as digital access to a 1:1 behavior change coach, a support group facilitated by a health coach, and a curriculum delivered via daily articles focused on nutrition, physical activity, and sustainable behavioral change.
PURPOSE: A urease inhibitor containing Oenothera odorata JACQ. extract and sea weed extract is provided to enhance the inhibition effect. CONSTITUTION: A urease inhibitor contains Oenothera odorata JACQ. extract and sea weed extract containing fucoidan as an active ingredient. The sea weed includes Laminaria japonica Areshoung or Undaria pinnatifida Harvey Suringar. The sea weed extract contains 0.5-3 parts by weight based on 1 part by weight of the Oenothera odorata JACQ. extract. The Oenothera odorata JACQ. extract is prepared using water, methanol, ethanol, isopropyl alcohol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, or ethyl acetate from Oenothera laciniata, Oenothera striata, Oenothera biennis, or Oenothera erythrosepala. The Oenothera odorata JACQ. extract contains a large amount of ellagic acid, pentagalloyl glucose, gallic acid, catechin, procyanidins, and proanthocyanidin.
The invention discloses a preparation for treating vasculitis, which is mainly characterized by treating osteonecrosis and black and surgery-induced disability. The formula of the nostrum comprises: hydrated lime, prepared common monkshood daughter root, sulfur, rehmanniae vaporata, Chinese angelica, white paeony root, szechuan lovage rhizome, codonopsis pilosula, largehead atractylodes rhizome, Indian Buead, peach seed, safflower, dragon's blood, astragalus root, vanillin, liquoric root, ephedra herb and steamed carp, wherein the hydrated lime, prepared common monkshood daughter root and sulfur serve as monarch medicaments; the rehmanniae vaporata, Chinese angelica, white paeony root, szechuan lovage rhizome, codonopsis pilosula, largehead atractylodes rhizome, Indian Buead, peach seed, safflower, dragon's blood and astragalus root serve as minister medicaments; the vanillin, liquoric root and ephedra herb serve as guide medicaments; and the steamed carp serves as an assistant medicine. The monarch medicaments account for 40 percent; the minister medicaments account for 40 percent; the assistant medicaments account for 20 percent; the monarch medicaments contain 40 percents of hydrated lime, 40 percents of prepared common monkshood daughter root and 20 percent of sulfur; and the components of the minister medicaments and the component of the guide medicaments are uniform in content. The components are divided uniformly, mixed and ground into powder, and the powder is filled into capsules. 3 to 30 capsules are taken each day after meals with steamed carp soup in an amount which is 3 times that of the capsules. The nostrum for treating vasculitis has functions of warming yang, tonifying qi, dispersing cold, relieving stagnation, activating blood and eliminating stasis. The west medicine can treat yang symptoms but not yin symptoms. Particularly, for treating stage III osteonecrosis, a lesion is cut off, which leads to disability.
Neck pain is a common complaint that can occur for different reasons and is common among the public. The most common musculoskeletal system pathology after low back pain is neck pain. Neck pain symptoms often do not provide a permanent solution. Chronic neck pain is a sensory and emotional experience that affects an individual's quality of life, behavior and professional life. In addition, psychosocial status is also affected due to problems such as health expenses, work attendance problems, and work efficiency. Early diagnosis and identification of risk factors are of great importance to prevent neck pain from turning into a chronic problem. 40-70% of the society complains of neck pain at least once in their lives. About ¼ of these are chronic neck pain. Today, many occupational and personal risk factors for neck pain have been identified. The purpose of the research; The aim of this study is to examine the positive and negative effects of kinesio tape application in addition to traditional treatment on pain, functional status and neck awareness in patients with neck pain.