anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pelvic floor dysfunction encompasses a group of disorders that negatively affect the quality of women's lives. These include pelvic organ prolapse (POP), urinary incontinence, and sexual dysfunction. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being post-menopausal women over 65. Prolapse recurrence rates following surgery were reported to be as high as 30%. This may be attributed to ineffective healing in the elderly. Autologous stem cell transplantation during surgery may improve surgical results. In our previous studies, we showed that the transplantation of bone marrow-derived mesenchymal stem cells (MSCs) from young donor rats improved the healing of full-thickness vaginal surgical incision in the vaginal wall of old rats, demonstrated by both histological and functional analysis. In order to translate these results into the clinical reality of autologous MSC transplantation in elderly women, we sought to study whether stem cells derived from old donor animals would provide the same effect. In this study, we demonstrate that MSC transplantation attenuated the inflammatory response, increased angiogenesis, and exhibited a time-dependent impact on MMP9 localization. Most importantly, transplantation improved the restoration of the biomechanical properties of the vagina, resulting in stronger healed vaginal tissue. These results may pave the way for further translational studies focusing on the potential clinical autologous adjuvant transplantation of MSCs for POP repair for the improvement of surgical outcomes.
A computer system referred to as a Database Management System with Nested Time Axes (DBMS with NTA), which cooperates with a Computed Medical File and Chart System (CMFCS), employs data processing techniques to solve problems related to data collection and analysis in daily medical practice. It reconstructs irregularly or regularly collected data and places it into a database table with a standardized time axis acceptable for the CMFCS. Multiple records of an original database at irregular intervals are correlated to a progeny database with a standardized time axis by averaging, maximizing and minimizing. The DBMS with NTA consists of several database tables, each of which has a relational time axis, and corresponding programs to reconstruct a root database table to a progeny database table in hierarchical order. The DBMS with NTA cooperating with the CMFCS allows users to automatically create computer displayed medical charts from the short range view (microscopic view) via the standard view to the long range view (wide angle view) serially using several different time axes. It also creates a computer displayed medical chart showing the maximum and minimum values along with the average value in the same time axis.
BACKGROUND: Delirium, marked by acute cognitive decline, poses a life-threatening issue among older individuals, especially after cardiac surgery, with prevalence ranging from 15 to 80%. Postoperative delirium is linked to increased morbidity and mortality. Although clinical trials suggest preventability, there is limited research on intranasal insulin (INI) for cardiac surgery-related delirium. INI has shown promise in managing cognitive disorders. It rapidly elevates brain hormone levels, enhancing memory even in non-impaired individuals. While effective in preventing delirium in gastrointestinal surgery, its impact after cardiac surgery remains understudied, especially for middle-aged patients.
METHOD: This is a prospective randomized, double-blind, single-center controlled trial. A total of 76 eligible participants scheduled for elective on-pump cardiac surgery will be enrolled and randomly assigned in a 1:1 ratio to either receive Intranasally administered insulin (INI) or intranasally administered normal saline. The primary outcome of our study is the incidence of postoperative delirium (POD). Secondary outcomes include duration of ICU, postoperative hospital length of stay, all in-hospital mortality, the change in MMSE scores pre- and post-operation, and incidence of postoperative cognitive dysfunction at 1 month, 3 months, and 6 months after operation. Moreover, we will subjectively and objectively evaluate perioperative sleep quality to investigate the potential impact of nasal insulin on the development of delirium by influencing sleep regulation.
DISCUSSION: Our study will aim to assess the impact of intranasal administration of insulin on the incidence of postoperative delirium in middle-aged patients undergoing on-pump elective cardiac surgery. If intranasal insulin proves to be more effective, it may be considered as a viable alternative for preventing postoperative delirium.
TRIAL REGISTRATION: ChiCTR ChiCTR2400081444. Registered on March 1, 2024.
A base or saddle for artificial dentures comprises a rubber derivative prepared by treating rubber with a halogen containing compound of an amphoteric metal.  The halogen compound may be either a chloride of the metal, in which case a hydrocarbon product with the empirical formula (C5H8)x results, or it may be chlorostannic acid, in which case the rubber derivative formed contains chlorine. Fillers and colouring matters may also be incorporated into the composition.  The experimental procedure necessary to produce the chlorostannic acid derivative is described in detail in an example. Metal chlorides mentioned which may be used to react with the rubber are stannic chloride, aluminium chloride, or chromic chloride.ALSO:A base or saddle for artificial dentures comprises a rubber derivative prepared by treating rubber with a halogen containing compound of an amphoteric metal.  Fillers and colouring matters may also be incorporated in the composition.
BACKGROUND: Islet transplantation is a promising therapy for patients with type 1 diabetes. However, ischemic injury to the donor islets during cold preservation leads to reduced islet quality and compromises transplant outcome. Several studies imply that liraglutide, a glucagon-like peptide-1 receptor agonist, has a positive effect on promoting islet survival, but its impact on islet cold-ischemic injury remains unexplored. Therefore, the aim of this study was to investigate whether liraglutide can improve islet transplantation efficacy by inhibiting cold-ischemic injury and to explore the underlying mechanisms.
METHODS: Liraglutide was applied in a mouse pancreas preservation model and a human islets cold-preservation model, and islet viability, function, oxidative stress levels were evaluated. Furthermore, islet transplantation was performed in a syngeneic mouse model and a human-to-nude mouse islet xenotransplantation model.
RESULTS: The supplementation of liraglutide in preservation solution improved islet viability, function, and reduced cell apoptosis. Liraglutide inhibited the oxidative stress of cold-preserved pancreas or islets through upregulating the antioxidant enzyme glutathione levels, inhibiting reactive oxygen species accumulation, and maintaining the mitochondrial membrane integrity, which is associated with the activation of Akt signaling. Furthermore, the addition of liraglutide during cold preservation of donor pancreas or donor islets significantly improved the subsequent transplant outcomes in both syngeneic mouse islet transplantation model and human-to-nude mouse islet xenotransplantation model.
CONCLUSIONS: Liraglutide protects islets from cold ischemia-related oxidative stress during preservation and hence improved islet transplantation outcomes, and this protective effect of liraglutide in islets is associated with the activation of Akt signaling.
The invention relates to a medicine field, in particular to an aspartic acid amlodipine series salt, the preparation, and composition, preparation and tablet thereof. The invention provides a new compound-aspartic acid amlodipine series salt and the preparations. The preparation method is as follows: under the normal temperature, amlodipine is dissolved in organic solvents, and aspartic acid dissolved in organic solvent is dripped into the organic solvent. Then, they are mixed for complete reaction. At last, the obtained solution is cooled for crystallization, and the crystal is filtered to produce aspartic acid amlodipine series salt. The product of the invention is suitable for preventing or curing ischemia and hypertension.
The invention provides a quinoxaline derivative containing a phenylhydrazide skeleton, a preparation method thereof and application thereof in preparing an antitumor drug. The structural formula of the quinoxaline derivative containing the phenylhydrazide skeleton is shown as a formula X: r is selected from hydrogen, halogen, alkyl, nitryl, alkoxy and halogenated alkyl. The preparation method comprises the step of reacting the phenylhydrazide and the quinoxaline derivative to obtain the compound. The quinoxaline derivative containing the phenylhydrazide skeleton has obvious inhibition effect on cervical cancer cells (Hela), lung cancer cells (A549), melanoma cells (F10) and liver cancer cells (HepG 2). The quinoxaline derivative containing the phenylhydrazine skeleton is obtained by effectively integrating the pharmacodynamic groups quinoxaline and the hydrazide. The synthesis method has the advantages of strong repeatability, good stability, simple reaction conditions, mild experimental environment and good yield, and can be used for mass production under the condition of small investment.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to application in biomedicine, cell technologies, substituting and restorative surgery, in particular for manufacturing matrix-carrier, implanted together with cells into human organism in order to restore functioning of affected organ. Method lies in preparation of solution of polyoxybutirate-polyoxyvalerate (POB/POV) in dichloroethane, after which into solution introduced is icy acetic acid with the following component ratio, g: POB/POV - 1-2, dichloroethane- 10-12, icy acetic acid - 10-15; obtained solution is frozen in form at temperature minus (25-30)C and sublimation drying of obtained semi-product of matrix is performed in vacuum chamber. Freezing of solution and sublimation drying of obtained semi-product of matrix are performed on padding, made from polytetrafluorethylene fiber and plate from water ice. Thickness of water ice plate is selected on condition of its complete sublimation during drying in vacuum chamber, sublimation drying of matrix semi-product on padding being performed on mesh from plastic threads. Initial pressure in vacuum chamber must be not lower than 100 Torr, and after dichloroethane evaporation from matrix semi-product pressure in vacuum chamber is reduced to ~0.01 Torr. Polymer matrix with bimodal structure of simply connected pores is produced. ^ EFFECT: simplification and cheapening of technology due to refuse from low temperature of performing vacuum sublimation drying. ^ 7 cl, 4 dwg
The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, the intradermal compartment of a subject’s skin. The present invention provides an improved method of delivery of biologically active agents, such as therapeutic agents, through lymphatic vasculature accessed by intradermal delivery. Therapeutic agents to be delivered in accordance with the present invention include, but are not limited ton antineoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenesis agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present invention have improved bioavailability, including improved systemic distribution and improved delivery to particular tissues. Therapeutic agents, delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over convention drug delivery methods including dose sparing, increased drug efficacy, reduced side effects, reduced metastatic potential and prolonged survival.
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) has high mortality rates. The osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL)/receptor activator of nuclear factor-κB (RANK)/Toll-like receptor 4 (TLR4) pathway and its potential role in SA-AKI pathogenesis remain to be fully understood. Herein, we addressed this issue using mouse models.
METHODS: An SA-AKI mouse model was established using the cecal ligation and puncture method (CLP). Mice were grouped into sham, CLP model, CLP + recombinant RANKL, and CLP + anti-RANKL groups. Serum creatinine (Scr) and blood urea nitrogen (BUN) levels were measured to assess kidney function. ELISA was used to detect serum IL-1β, TNF-α, and IL-6 levels. Real-time quantitative PCR and Western blot were used to detect the mRNA and protein expression levels of OPG, RANKL, RANK, and TLR4 in kidney tissues. HE staining was performed to evaluate the pathological changes.
RESULTS: The CLP model group showed higher levels of Scr and BUN, indicating impaired kidney function in SA-AKI, compared to the sham group. Treatment with recombinant RANKL in the CLP + recombinant RANKL group reduced Scr and BUN levels, while anti-RANKL treatment in the CLP + anti-RANKL group elevated their levels. Moreover, the CLP model group had significantly increased IL-1β, TNF-α, and IL-6 than the sham group, indicating elevated inflammation in SA-AKI. The CLP + recombinant RANKL group demonstrated decreased cytokine levels, whereas the CLP + anti-RANKL group showed an increase. Additionally, the histopathological evaluation revealed distinct kidney tissue damage in the CLP model group. Recombinant RANKL treatment reduced this damage, while anti-RANKL treatment exacerbated it. Mechanically, the mRNA and protein expression of RANKL were significantly decreased, while those of OPG, RANK, and TLR4 were significantly increased in the CLP model group and the CLP + anti-RANKL group. Interestingly, treatment with recombinant RANKL reversed these changes, as evidenced by significantly increased RANKL but decreased OPG, RANK, and TLR4.
CONCLUSION: The OPG/RANKL/RANK/TLR4 pathway is involved in SA-AKI pathogenesis. Recombinant RANKL treatment attenuates the inflammatory response and kidney tissue damage in SA-AKI, possibly via regulating this pathway. This pathway shows promise as a therapeutic target for SA-AKI.
A composition for the regional/local delivery of chemotherapeutic (anti-proliferative) agents for treatment of cellular proliferative diseases such as cancer is described. Also described is the use of the composition in the manufacture of a medicament and a kit comprising the composition. The composition comprises at least one anti-proliferative agent in a substantially non-aqueous (less than 30% water) gel delivery vehicle that is capable of acting as a depot for the agent. The gel delivery vehicle is pharmaceutically acceptable and comprises at least one polar organic solvent (80-99.5% of vehicle) that provides a continuously liquid phase, and at least one thickening agent (0.5-20% of said vehicle). The vehicle must retain enough fluidity to be delivered via needle or catheter. The composition may also additionally comprise a vasoconstrictive agent.
Hybrid rendering systems for medical imaging applications are provided. In some embodiments, an indication of a viewing mode is received at a medical image viewer from a user. The viewing mode is a diagnostic mode or a referential mode. A plurality of characteristics of the medical image viewer are determined. Based upon the viewing mode and the plurality of characteristics of the medical image viewer, a rendering mode is determined. The rendering mode is a server-side rendering mode or a client-side rendering mode. A request for medical imagery is sent. The request conforms to the rendering mode. The medical imagery is rendered according to the rendering mode. The requested medical imagery is displayed on the medical image viewer.
This parallel, double blind, randomized, controlled, multi-center study will evaluate the efficacy and safety of salvianolate injection in elderly patients with unstable angina pectoris. Patients will treated with or without salvianolate injection on the basis of conventional therapy for 14 days. The primary measures of effectiveness include the change from baseline to the end of treatment in the angina scores.(Angina score table :sum of 4 items), the variation of EKG (level of the S-T segment)., Additional measures of effectiveness include the change from baseline to the end of the treatment in the Seattle Angina Questionnaire(SAQ),EuroQol-5 Dimensions(EQ-5D) will be performed throughout the study. Patients who complete the double-blind portion of the study will be followed up 28 days. Effectiveness will be assessed at 7 days, 14 days and 28 days. Safety evaluations (incidence of adverse events,, physical examinations, laboratory tests) will be performed at at 7 days, 14 days and 28 days of the study.
The present disclosure provides a method for formulating a composition of isolated and purified microbes. The present disclosure provides methods for formulating a composition for administration to a subject in need thereof. The method can comprise obtaining a mixture that is substantially dry and comprises about 10% or less residual moisture. The mixture can comprise a population of isolated and purified microbes and a pharmaceutically acceptable carrier. The population can comprise one or more obligate anaerobes that are oxygen-stable. The methods can further comprise encapsulating said mixture in an enteric-coated capsule for delivery to said subject.
PURPOSE:To provide a perfumery composition containing a straight-chain trans- 6-alkenoic acid, giving or promoting the milky smell when used as a perfume for cosmetics, foods, feeds, tobacco, etc., giving mildness to the smell, and free of toxicity. CONSTITUTION:The objective perfumery composition contains 0.01-10wt% compound of formula (n is integer of 1-4). The use of the compound of formula as a component of a perfume enables to give remarkably milky smell to the composition, and give the perfume note with mildness caused by the milky smell. Since it is nontoxic and has excellent milky smell, the effects can be exhibited more remarkably when used as a perfumery component of e.g. dairy products. The above perfume composition may be mixed with other perfumes, diluents,  etc. according to the use.
BACKGROUND: Psoriasis has a global prevalence of 1-3%, with variations observed across different ethnic groups and geographical areas. Disease susceptibility and response to anti-tumor necrosis factor-α (TNFα) drugs suggest different genetic regulatory mechanisms which may include NLR family pyrin domain containing 3 (NLRP3) polymorphism. Evaluation of the NLRP3 gene polymorphism, the serum level of CRP and TNFα in psoriasis patients and assessment of the NLRP3 (rs10754558) gene polymorphism, CRP and TNFα with disease severity and their role as biomarkers for response to Methotrexate and Adalimumab in psoriasis. The study had a total of 75 patients diagnosed with psoriasis vulgaris, who were compared to a control group of 75 healthy individuals.
RESULTS: There was a highly significant difference in NLRP3 genotypes and alleles distribution between psoriasis patients and controls (P = 0.002,0.004). The heterozygote genotype GC (OR = 3.67,95%CI:1.75-7.68, P = 0.0006), was linked with increased risk of psoriasis. Additionally, The GC genotype was significantly associated with nonresponse to psoriasis therapy (OR = 11.7,95%CI:3.24-42.28, P = 0.0002). Regarding serum CRP and TNFα levels, there was a highly statistically significant difference between psoriasis patients and controls (P < 0.0001), and there was also a highly statistically significant difference between responders and non-responders in psoriasis patients regarding PASI 50 (P < 0.0001).
CONCLUSIONS: The NLRP3 (rs10754558) genotypes GC was associated with the severe form of psoriasis and with nonresponse to psoriasis medication. Therefore, NLRP3 (rs10754558) gene polymorphism is an important prognostic biomarker in psoriasis patients. The serum TNFα can be used as a predictor for response to therapy in psoriasis patients. More research for evaluation of role of the NLRP3 gene polymorphism in the genetic risks and treatment outcomes associated with psoriasis is still required.
Anaphylaxis is a severe life-threatening systemic hypersensitivity reaction caused by release of mediators from mast cells and basophils, characterized by cutaneous, respiratory, cardiovascular, or gastrointestinal signs and symptoms. The most common specific causes of anaphylaxis are venom, drug, and food allergies (i.e. patients with specific anaphylaxis, SA), When a causative factor is not identified in patients are said to have idiopathic anaphylaxis (IA). Evidence of an underlying clonal mast cell disease has been found in about I in 15 patients with IA in our studies and in about 1 in 12 patientswith venom induced anaphylaxis in a European study. (1) The number of patients with anaphylaxis to foods or drugs who have a clonal mast cell disease is not known and the number or patients with venom induced anaphylaxis in the US with clonal mast cell disease has not been determined. Thus, a more complete understanding of the prevalence of clonal mast cell disease in those experiencing anaphylaxis and a better understanding of the associated laboratory abnormalities and disrupted molecular signaling pathways will have a substantial impact of the clinical management of patients who present with anaphylaxis.

This protocol thus focuses on determining the prevalence of clonal mast cell disorders in patients with the anaphylaxis, whether unexplained (IA) or associated with exposure to an antigen (SA), and attendant changes in the mast cell compartment. Subjects 13 - 75 years old will be evaluated to correlate both clinical and laboratory features of anaphylaxis and to identify genetic and molecular pathways that may predispose to these events. Subjects may undergo bone marrow examination in addition to supporting laboratory studies when indicated. We plan to enroll up to 200 subjects.
The cross talk between calcium (Ca2+), IP3 and buffer dynamics regulate various mechanisms in hepatocyte cells. The study of independent systems of calcium, IP3, and buffer signaling provides limited information about cell dynamics. In the current study, coupled reaction-diffusion equations are used to design a cross-talk model for IP3, buffer, and calcium dynamics in a hepatocyte cell. The one-way feedback of calcium, buffer, and IP3 in ATP production, ATP degradation, and NADH production rate is incorporated into the model. Numerical simulation has been done using the Finite Element Method (FEM) along the spatial direction and the Crank-Nicolson (C-N) method along the temporal direction. The numerical results are analysed to determine the effects of alterations in processes of cross-talking dynamics of IP3, buffer, and calcium on ATP and NADH production and degradation rate of ATP in a hepatocyte cell under normal and obesity conditions. The comparative analysis of these findings unveils notable distinctions induced by obesity in calcium dynamics, ATP and NADH synthesis, and ATP degradation kinetics.
The pseudomonas active protein is composed of corpuscle protein, endotoxic protein, mucus protein and etc. By adopting 11 pseudomonas i. e. pyocyaneus pseudomonas 1. 2. 3. 4. 5. 6 and 11 serotype standard strains and malt-philic pseudomonas, malodorous pseudomonas, alkaligenic pseudomonas etc. lyophilized standard strains to separate and extract corpuscle protein, toxoid of exotoxin and endotoxic protein, which possess of good immune active components (antigen components) to synthesize the pseudo monas active protein. Said product is used to prevent and cure the chronic pulmonaryinfection of pulmonary heart disease and infections due to pseudo monas.