anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
POETRY is an 8-week study of 30 post-menopausal women with Parkinson's disease (PD) who will be enrolled at six clinical sites in the United States. The study is designed to measure the safety and tolerability of estrogen replacement therapy (ERT). The study will also measure how ERT affects thinking and behavior, movement and activities of daily living, as well as motor fluctuations and dyskinesias. Although we know there are gender differences in PD, no studies have assessed their impact on symptom management. Women with PD usually require less levodopa, are more likely to experience drug-related dyskinesia, and commonly report changes of their symptoms with menstruation, menopause and use of hormones, implying that hormonal changes may impact PD symptoms. All perimenopausal women face the decision whether or not to use estrogen replacement therapy (ERT) and for women with PD, information about estrogen's effects in PD may facilitate decision-making.
Participants will go through an initial washout maintaining a low-fiber diet for 14 days. After washout, participants will be instructed to consume 100 grams of durian pulp every day following their breakfast or dinner for 1 week. Participants will then continue to consume 200 grams of durian pulp every day during the 2nd week of intervention and then will go through another washout for 2 weeks. During the intervention period, participants will be informed to maintain low-fiber diet. All participants will be required to note down their stool consistency and stool frequency and 3-days dietary records. Stool and blood samples will be collected at 4 time points during the study period (baseline, 1-week of intervention, 2-weeks of intervention and 2-weeks washout) and will be stored at -80 °C until analysis.

The first outcomes of this study will provide insights into the interplay between durian consumption, gut microbiome, and host metabolome, as well as whether durian consumption can improve the clinical parameters (plasma glucose levels, lipid profiles and HbA1c levels) of healthy subjects. The interplay between diets, gut microbiome, host metabolome and genetic polymorphism data in healthy population will lay the groundwork to develop the precision nutrition strategy based on our regional food. These findings have potential to improve the health and well-being of the communities in our region.
PURPOSE: The extracts of natural substances for cosmetic are provided which is used as the raw material of cosmetic and obtained by the purification after heating and extracting natural substances. CONSTITUTION: The extracts of natural substances for cosmetics are obtained by the following steps. They are as follows: 1)The natural substances such as a delay seed coat, Lingusticum chuanxiong root, apricot stone, licorice, Scutellaria baicalensis, Angelica gigas root, mung bean, A gelicae dahuricae, Saururus chicness, ginseng leaf, Aconitum koreanum, Trichosanthis Radix, Eucommia ulmoides, Ledebouriella seseloides, Angelica tenuissima, Ampelopsis Radix, Cortinellus shiitake mushroom are mixed in the suitable mixing ratio, and 4-5 volumes of 1,3-butyleneglycol being 10% are added into the above raw materials. 2)The mixture is firstly heated at 65°C for 3-5 hours and then heated at 100-120°C for 3-5 hours again. 3)The mixture is extracted under the reduced pressure. 4)The extracts are filtrated using glass-filter-4G and con condensed under the reduced pressure. 5)The con condensed extracts are purified by column chromatography which is consisted of activated carbon and zeolite in a weight ratio of 3: 1 using water or ethanol as mobile phase.
This invention provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein which expresses on the surface of one cell type but not the other. This invention also provides a method for preparing a hybridoma cell line which produces an antibody capable of specifically binding to a cell surface-expressed protein. This invention provides a method to prepare a hybridoma cell line which specifically recognizes and binds to a tumor associated antigen associated with a neoplastic, human cell. This invention also provides a method of preparing DNA encoding a cell surface antigen associated with a neoplastic, human cell. This invention further provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Carcinoma Tumor Antigen Gene-1. This invention also provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-1. This invention provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-2. Finally, this invention provides an isolated mammalian nucleic acid molecule having the sequence of Prostate Tumor Inducing Gene-1.
BACKGROUND: Left ventricular diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes including atrial fibrillation. Whether DD is independently associated with incident stroke and transient ischemic attack (TIA) and with bleeding events is not known. We performed this observational cohort analysis to examine the impact of DD on the risk of stroke/TIA and major bleeding.
METHODS: Patients who underwent at least 1 cardiac echocardiogram and were followed for at least 3 months were included in this study. Patients with a prior history of stroke, TIA, or major bleeding, as determined by International Classifications of Diseases codes, were excluded. Smart key-phrase search was applied to echocardiographic reports to classify patients into 4 groups based on the most severe DD assessment. Patients in whom the presence of DD could not be determined were excluded. The final study cohort was followed to the end point of hospital admission for stroke/TIA and major bleeding, and independent predictors of these events were evaluated using the multivariable Cox proportional hazards method.
RESULTS: The final study cohort (age, 56±18 years; 56% women) had 96 702 patients with no DD and 18 164, 5881, and 1340 patients with DD grades I, II, and III, respectively. Over a median follow-up of 3.4 years, 2938 (2.4%) patients were hospitalized for stroke/TIA and 5567 (4.6%) for major bleeding. After adjusting for age, the CHA2DS2-VASc score, chronic kidney disease, use of antiplatelet agents, use of anticoagulation agents, the year of echocardiographic testing, household income, and history of atrial fibrillation, DD remained a strong predictor of incident stroke/TIA (hazard ratio, 1.22 per grade increase in DD [95% CI, 1.16-1.29]; P<0.001) and major bleeding (hazard ratio, 1.20 per grade increase in DD [95% CI, 1.16-1.25]; P<0.001).
CONCLUSIONS: DD is independently associated with a higher risk of cerebrovascular accidents and major bleeding. DD should be considered when counseling patients regarding their risk profile and management options.
Anaesthesiologists commonly use intravenous labetalol to adjust patient haemodynamics during surgical procedures. Cases of profound hypotension after continuous labetalol infusions have been reported; however, there is limited evidence regarding the safety of intraoperative labetalol boluses. This audit examined the frequency of postoperative hypotension and bradycardia in 292 adult non-cardiac surgery patients treated with intraoperative labetalol boluses. Blood pressure and heart rate data were collected from the post-anaesthesia care unit and on the floor units for 24 hours after surgery. The median total intraoperative labetalol dose was 10mg. A total of 30/292 patients had all-cause postoperative hypotension within 24 hours of surgery, 26 of which had other medical or surgical precipitants. Fifteen patients developed bradycardia. There were no deaths or intensive care unit admissions attributed to labetalol. This audit demonstrates a low risk of all-cause postoperative hypotension (10%) and bradycardia (5%) after the use of small IV doses of intraoperative labetalol.
Patients receive trastuzumab IV over 90 minutes on day in course 1. Patients receive docetaxel IV, carboplatin IV, and trastuzumab IV over 30 minutes on day 1 in course 2-7. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
<P>PROBLEM TO BE SOLVED: To provide a combination of amphipatic substances forming aggregate suspensions in a polar liquid.  <P>SOLUTION: Judicious choice of system components, which differ at least 2-times to 10-times in solubility, ensures the aggregates to have extended, unusually adaptable surfaces. This is due to simultaneous action on the aggregates of at least two soluble substances amongst three system components, at least one of which is an active ingredient and preferably a drug; the third component, alternatively, can take the role of a drug. The application further deals with the use of the combinations in pharmaceutical preparations transporting drugs into the body of warm blood creatures. This is made possible by the drug loading capability of the aggregates with the highly flexible and deformable coating, which renders the resulting drug carriers highly adaptable. The application finally reveals suitable methods for manufacturing and usage of the carriers.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Extracellular vesicles (EVs) are tools for intercellular communication, mediating molecular transport processes. Emerging studies have revealed that EVs are significantly involved in immune processes, including sepsis. Sepsis, a dysregulated immune response to infection, triggers systemic inflammation and multi-organ dysfunction, posing a life-threatening condition. Although extensive research has been conducted on animals, the complex inflammatory mechanisms that cause sepsis-induced organ failure in humans are still not fully understood. Recent studies have focused on secreted exosomes, which are small extracellular vesicles from various body cells, and have shed light on their involvement in the pathophysiology of sepsis. During sepsis, exosomes undergo changes in content, concentration, and function, which significantly affect the metabolism of endothelia, cardiovascular functions, and coagulation. Investigating the role of exosome content in the pathogenesis of sepsis shows promise for understanding the molecular basis of human sepsis. This review explores the contributions of activated immune cells and diverse body cells' secreted exosomes to vital organ dysfunction in sepsis, providing insights into potential molecular biomarkers for predicting organ failure in septic shock.
Automated control of oxygen therapy partnered with bCPAP delivered as per standard practice. The automated oxygen control set-up (OxyMate) will consist of: continuous pulse oximetry input, a computer algorithm (VDL1.1) that calculates changes to delivered FiO2 based on the input SpO2, and a mechanism to automatically effect changes to delivered FiO2. The system will target an SpO2 of 93% (mid-point of the target range). There will be several embedded safety mechanisms, including the ability to manually over-ride OxyMate at any stage. Pulse oximeter alarms will be as for the manual control arm, with additional automated system alarms in place.
An empty medicine and food capsule is disclosed,  in which the capsules are continuously and mechanically produced, and the trademark,  the content of the medicine and the like are printed on the outside of the capsule,   before filling the medicine into the capsule.  A plurality of function protuberances are formed on the annular projection of the conventional type cap at certain intervals, such that the function protuberances would protrude more deeply inwardly.   The structure of the function protuberances is simple,  and therefore,  the designing of the die is simple and can be precisely carried out.   Consequently, precise capsules can be manufactured.    Further,    the semi-locking and the final locking can be prevented during the pre-coupling,   while,  after the final coupling,   an inadvertent separation of the capsule can be prevented.   Thus the problem of the non-separation of the capsule during the filling of the medicine and the problem of the inadvertent separation of the capsule after the final coupling are solved.  Therefore,   a high quality medicine and food hard capsule is provided.
FIELD: medicine, microbiology. SUBSTANCE: method involves administration in patient the silver electrolytic solution in concentration 0.5-5.0 mg/l for 2-9 days. This solution can be used both independently and with antibiotics simultaneously. Method provides to neutralize the effect of hemolysin of pathogenic strains of colon bacillus. Invention can be used for inhibition of hemolytic activity of pathogenic strains of colon bacillus. EFFECT: enhanced effectiveness of treatment of patients. 3 cl, 3 tbl, 2 ex
OBJECTIVES: This study assessed the effectiveness of a virtual mindfulness-based stress reduction (MBSR) program to improve quality of life and pain in people with endometriosis.
METHODS: This was a multiple-method, before and after study design. Fifteen patients with a clinical or surgical diagnosis of endometriosis were recruited from a Canadian outpatient gynaecology clinic. Participants completed the Endometriosis Health Profile, a validated survey tool, and a pain medication use questionnaire before and after a virtual 8-week MBSR program run by an experienced social worker. A focus group was held upon completion of the program to assess participants' experiences using mindfulness for management of endometriosis symptoms. Quantitative data was analyzed with paired-samples t tests. Qualitative data was thematically analyzed.
RESULTS: A total of 67% of people enrolled completed the MBSR course (10/15). Following the MBSR program, participants had a statistically significant decrease in 4 components of the Endometriosis Health Profile: control and powerlessness (P = 0.012), emotional well-being (P = 0.048), social support (P = 0.030), and self-image (P = 0.014). There was no change in pain scores or medication use. Participants felt the program's benefits came from a sense of community, education about their condition, and application of mindfulness tools when approaching pain. Participants felt more comfortable with the virtual format over in-person sessions.
CONCLUSIONS: A virtual MBSR course can improve quality of life domains in people with endometriosis. The virtual format was effective and preferred by participants. Virtual MBSR programs may increase access to this type of care.
The utility model discloses a medicinal plaster for promoting menstrual flow and blood circulation. The utility model comprises a cotton cloth layer. A paper supporting layer is stuck to one surface of the cotton cloth layer and a medicine layer is arranged on the other surface of the cotton cloth layer. A covering layer is arranged on the medicine layer. The utility model has the advantage of novel and reasonable structure. The hardness of the cotton cloth layer can be increased by means of the paper supporting layer and the coating medicine layer is convenient and reliable. The covering layer can effectively prevent medicine from pollution. Patient clothing contamination caused by the fall of the medicinal plaster can be effectively prevented through arranging a fixing adhesive tape. Used medicine has obvious effects of menstrual flow and blood circulation. The utility model is particularly suitable for patients with diseases of lumbocrural pains.
Posttraumatic headache (PTH) is common following traumatic brain injury and impacts quality of life. We investigated descending pain modulation as one possible mechanism for PTH and correlated it to clinical measures. Pain-related evoked potentials (PREP) were recorded in 26 PTH-patients and 20 controls after electrical stimulation at the right hand and forehead with concentric surface electrodes. Conditioned pain modulation (CPM) was assessed using painful cutaneous electric stimulation (PCES) on the right hand as test stimulus and immersion of the left hand into 10 °C-cold water bath as conditioning stimulus based on changes in pain intensity and in amplitudes of PCES-evoked potentials. All participants completed questionnaires assessing depression, anxiety, and pain catastrophising. PTH-patients reported significantly higher pain ratings during PREP-recording in both areas despite similar stimulus intensity at pain threshold. N1P1-amplitudes during PREP and CPM-assessment were lower in patients in both areas, but statistically significant only on the hand. Both, PREP-N1-latencies and CPM-effects (based on the N1P1-amplitudes and pain ratings) were similar in both groups. Patients showed significantly higher ratings for anxiety and depression, which did not correlate with the CPM-effect. Our results indicate generalized hyperalgesia for electrical stimuli in both hand and face in PTH. The lacking correlation between pain ratings and EEG parameters indicates different mechanisms of pain perception and nociception.
The invention comprises tetrahydro-isoquinoline derivatives of the formula <FORM:0995369/C2/1> wherein n stands for 1, 2 or 3, R1 is a halogen atom and R2 is a hydrogen atom or an alkyl group containing up to 4 carbon atoms, and the corresponding compounds in which the hydroxyl group in the 6- or 7-position is replaced by an alkoxy group containing at least 2 carbon atoms or an acyloxy group, and acid-addition salts thereof.  The compounds are prepared by reductively debenzylating, e.g. using hydrogen in the presence of a metal hydrogenation catalyst, a compound of the formula <FORM:0995369/C2/2> and, if desired, replacing the hydrogen atom of the hydroxyl group in the 6- or 7-position by an alkyl group containing at least 2 carbon atoms or an acyl group by etherification or esterification as the case may be, and also if desired, converting the product of any of the foregoing steps into an acid-addition salt. Pharmaceutical compositions for enteral and parenteral administration having analgesic, antitussive and antirheumatic activity comprise a compound of the invention together with a pharmaceutically acceptable carrier.  They may be formulated as tablets, dragees, suppositories, capsules, solutions, suspensions or emulsions.  Specification 995,370 is referred to.
A perfume fixative comprises: (a) polyvinylpyrrolidone (PVP); (b) hydroxypropyl cellulose (HPC); and (c) hydrophobic oil. The perfume fixative is used by being incorporated in a perfume-containing formulation or product. The fixative is found to be effective in enhancing perfume life, even when the fixative is used at low levels. The efficacy even at low levels is surprising and unexpected, and the reason for this efficacy is not yet known. For practical reasons, the PVP and HPC together should not constitute more than about 0.5% by weight of the perfume-containing product. If these materials are present at higher levels they are discernible by the user, either by sight or feel, which is undesirable. However, the fixative is found to be effective in an amount corresponding to this constraint and also at lower levels. The invention also covers mixtures of perfume and fixative, mixtures of product base and fixative, and perfumed products including perfume and fixative.
NEW MATERIAL:The compound of formula (X1 is Lys or Arg; X2 is Gly or Val; X3 is Leu or Ile; X4 is Ile or Val). USE:An edible antibacterial agent. PREPARATION:The body surface of a larva of an insect belonging to biptera or hymenoptera (e.g. Sarcophaga peregrina) is incised and the body fluid is squeezed out after about 2 days. The cells are removed by centrifugal separation, and the super- natant liquid is heated in water bath to remove the fat and centrifuged. The centrifuged supernatant liquid is treated with ion exchange resin, concentrated by ultrafiltration, and separated into constituent components by gel filtration, etc. After separating into each component, the component containing the objective compound is purified by properly combining an adsorption chromatography, electrophoresis, etc., to obtain the compound of formula.
Hydroquinone is a skin bleaching agent which may produce undesired effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this product.

Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people.

Avoid unnecessary sun exposure, use an effective broad-spectrum sunscreen agent or protective clothing should be worn to cover bleached skin to prevent re-pigmentation from occurring.

Hydroquinone may produce exogenous ochronosis, a gradual blue-black darkening of the skin. If this condition occurs, discontinue treatment and consult your physician.

Avoid contact with eyes and mucous membranes. Keep out of reach of children. In case of accidental ingestion, call a physician or a poison control center immediately.
The present invention relates to the use of compounds with at least one metal-sensitive chemical shift for determining metal concentrations and/or measuring metal concentration changes, wherein the compound is selected from the group of: pyro-EGTA, EGTA, EDTA, AATA, APTRA, BAPTA, HIDA, citrate, CarboxyGlutamate (CGlu), arylazo chromotopic acid, beta-diketone (crown-ether), mono-, di-, or tri-pyridyl aniline, mono-, di-, or tri-pyridyl amine, trimethylphenylammonium, or derivatives thereof. The present invention further relates to biosensors comprising at least one of the compounds. The present invention also relates to the use of the compounds for diagnosing and/or monitoring treatment of a disease causing changes in metal concentrations. The present invention is furthermore related  to in vitro  and  in vivo  methods for determining metal concentration and/or measuring metal concentration changes using the compounds or biosensors. The present invention also relates to methods of diagnosing and/or monitoring treatment of a disease causing changes in metal concentrations wherein the compounds or biosensors are applied. The present invention also relates to use of the compounds or biosensors in quality control of food or in the examination of plants and organisms or for monitoring of environmental resources. The present invention further relates to novel derivatives of pyro-EGTA, AATA, APTRA and BAPTA as well as their uses.