anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides Pu'er and bitter gourd tea and a production method thereof, belonging to the health care drink technology. The product is prepared by 50-55% of dry bitter gourd pieces and 45-50% of Pu'er ripe tea by weight. The production method comprises the following steps: taking ripe bitter gourds, cleaning the ripe bitter gourds, removing the pulps, slicing the ripe bitter gourds, mixing the slices with the Pu'er tea leaves, rolling the mixture, drying the mixture and naturally storing the mixture in the warehouses for more than one year, thus obtaining the finished product. The tea has brown red and clear infusion after brewing and filtration and has special and highly sharp aroma. After drinking, the faint fragrance of the bitter gourds ensures the taste of the Pu'er tea to be more mellow and fuller. The natural physiologically-active components in the product are complete; therefore, the tea has more obvious pharmacological effect of lowering blood sugar level, blood pressure and blood fat. The cold and cool nature of the bitter gourds is moderately neutralized with the partially warm nature of the Pu'er tea; therefore, the tea overcomes the defect that people with weaker tolerance can not singly drink the tea for a long time. The Pu'er and bitter gourd tea is suitable for wider range of people and long-time drink as a health care functional drink.
OBJECTIVES: Measuring pain self-efficacy is suggested as relevant in patients with musculoskeletal disorders (MSDs) in a primary care setting. However, there is no pain self-efficacy questionnaire (PSEQ) available in Swedish. The aim of this study was to translate and culturally adapt PSEQ-2 to Swedish and evaluate reliability and validity in a population of patients with MSDs.
METHODS: A translation and cultural adaptation together with psychometric evaluation of reliability and validity were performed according to guidelines with three groups of participants with MSDs. First, a convenient sample of 25 individuals were interviewed in the translation process. Next, 61 participants completed the test-retest survey via social media or QR codes in waiting rooms in rehabilitation clinics. Finally, to evaluate construct validity questionnaires were obtained from 132 participants with MSDs in an ongoing randomized controlled trial.
RESULTS: The Swedish version of PSEQ-2 showed adequate face and content validity. The results of 0.805 on Cohen's weighted kappa indicate that the reliability of PSEQ-2SV in a group of adults with MSDs is on the border between substantial and almost perfect. The point estimate regarding relative rank variance, measuring the individual variation within the group, and relative concentration, the systematic change in how the assessments are concentrated on the scale's categories, shows minor systematic differences and some random differences not neglectable. The construct validity of pre-defined hypotheses was met to some degree.
CONCLUSION: The PSEQ-2SV has been accurately linguistically translated and tested for reliability and validity, in a population of MSDs, and is deemed to be able to be used in the clinic and in research. As there were some concerns regarding measurement error and systematic bias, more research could be of value.
Participants receive 16 hours of Father Factor curricula, 4 hours of The New Playbook curricula, 4 hours of Money Smart curricula over the course of five weeks. Participants also receive on-going job readiness support and post-employment support.
The utility model relates to an extraction separator, which is composed of a storage tank, a storage tank outer clamping sleeve, a liquid inlet pipe, a material inlet, a stirrer, a pipe wire type high shearing spreader, a tee switch valve, a storage tank discharge port, a film separating pump, a film separating component, an extraction liquid outlet, a slurry cycle pipe, a separation membrane return pipe, a tee reversing valve, a slag removing pipe and a thermostat. The high shearing spreader and the stirrer are used for carrying out extraction to powder materials, therefore extraction speed is high. Effectively components can be extracted completely in five to ten minutes under ordinary condition, which is one tenth to one twentieth of a traditional method. Extraction temperature is low, such as radix paeoniae alba, the utility model is used under 20 DGE, the extraction rate of the effective components is 15 percent higher than the extraction rate of heating extraction effectively components. The extraction rate of effective components is high, such as ganoderma, the technology is used under the same 100 DGE, the extraction rate of ganoderma polysaccharide is 200 200 percent higher than the extraction rate of traditional extraction. A cross flow film separator carries out separation to slurry which is extracted, impurities can be removed completely and extraction liquid which is obtained by using the technology is clear and transparent without any visible impurities.
Asymptomatic individuals between the ages of 18-65 who have not experienced neck pain during the last 1 year will be included in the control group. Within the scope of the evaluation for the assessment of pain by visual analog scale (VAS), standard evaluation posture Postural Analysis, range of motion for the evaluation of Elektrogonyometer, Nov stabilizer and force evaluation for a hand-held Dynamometer, Nov for brevity, brevity reviews left internal rotator muscles of the pectoral muscles with standard, fear of movement kinezyofobi Tampa scale for the assessment of the neck in apology etc.
FIELD: medicine, oncology. SUBSTANCE: method deals with treating the widely spread form of uterine body cancer of stage III. In preoperative period, it is suggested to incubate with a patient's autolymph and introduce a standard total course dosage of cytostatics being increased by 2 times as: cyclophosphane, 5-fluouracil and metotrexate intravenously, by drops for 2 h, twice a week, at 2-3-d long interval for 2 wk, 4 procedures, totally. The method enables to decrease the size of tumor and the degree of tumor process distribution. EFFECT: higher efficiency. 2 ex
The continuous release of municipal and industrial products into the environment poses a growing concern for public health. Among environmental pollutants, polystyrene (PS) stands out as a primary constituent of environmental plastic waste, given its widespread use and high production rates owing to its durability and user-friendly properties. The detection of polystyrene microparticles (PS-MPs) in various living organisms has been well-documented, posing a serious threat due to their potential passage into the human ecosystem. In this manuscript, we aimed to study the toxicological effects of low concentrations of pristine and photoaged PS-MPs in a murine macrophage cell line. To this purpose, PS-MPs were photoaged by indoor exposure to visible light to simulate environmental weathering due to solar irradiation (PS-MPs3h). Physical characterization revealed that the irradiation treatment results in particle degradation and the possible release of nanoparticles. Monocultures of the RAW264.7 cell line were then exposed to PS-MPs and PS-MPs3h at concentrations comparable to experimental measurements from biological samples, to assess cytotoxicity, intracellular oxidative stress, primary genotoxicity, and inflammatory effects. Significant toxicity-related outcomes were observed in cells treated with both pristine PS-MPs and PS-MPs3h even at low concentrations (0,10 μg/ml and 1 μg/ml). PS-MPs3h exhibited greater adverse effects compared to PS-MPs, including reduced cell viability, increased ROS production, elevated DNA damage, and upregulation of IL-6 and NOS2 gene expression. Therefore, we can conclude that changes induced by environmental aging in the physicochemical composition of PS microplastics play a crucial role in the adverse health outcomes associated with microplastic exposure.
Preoperative HBV DNA level is less than 1000 IU/ml, intraoperative intravenous drip of 2500 IU HBIG static note type, postoperative 1 and 15 days respectively to give 2500 IU HBIG static note type, a total of three times, then no longer apply. Preoperative HBV DNA level greater than 1000 IU/ml, the use of HBIG solution for: intraoperative intravenous drip of 5000 IU HBIG static note type, postoperative day 1, 15 days and 30 days respectively to give 2000-2500 IU HBIG static note type, a total of four times, since then no longer apply. Preoperative HBV DNA level of the unknown, preoperative immediate detection of DNA, intraoperative intravenous drip of 5000 iu HBIG static note type, choose according to test results after dosing frequency.
The tumor-vascular interface is a critical component of the tumor microenvironment that regulates all of the dynamic interactions between a growing tumor and the endothelial lining of the surrounding vasculature. In this paper, we report the design and development of a custom-engineered tumor-vascular interface system for investigating the early stage tumor-mediated pro-angiogenic dysfunctional behavior of the endothelium. Using representative endothelial cells and triple negative breast cancer cell lines, we established a biomimetic interface between a three-dimensional tumor tissue across a mature, functional endothelial barrier using a magnetically hybrid-integrated tumor-vascular interface system, wherein vasculature-like features containing a monolayer of endothelial cell culture on porous microfluidic channel surfaces were magnetically attached to tumor spheroids generated on a composite polymer-hydrogel microwell plate and embedded in a collagen matrix. Tumor-mediated endothelial microdynamics were characterized by their hallmark behavior such as loss of endothelial adherens junctions, increased cell density, proliferation, and changes in cell spreading and corroborated with endothelial YAP/TAZ nuclear translocation. We further confirm the feasibility of drug-mediated reversal of this pro-angiogenic endothelial organization through two different signaling mechanisms, namely, inhibition of the vascular endothelial growth factor pathway and the Notch signaling pathway, thereby demonstrating the utility of the tumor-vascular interface platform for rapid, early stage prediction of antiangiogenic drug efficacy. Overall, our work emphasizes the importance of our strategic engineering approach for identifying some unique, physiologically relevant aspects of the tumor-vascular interface, which are otherwise difficult to implement using standard in vitro approaches.
In the face-to-face health care system, especially due to the pandemic period, the problem of personnel need to provide health care can be solved with mobile health applications; thus, mobile health applications can indirectly help workforce problems. Mobile applications allow the provision of high quality, useful services with less energy and cost to large audiences. In addition, mobile health applications allow patients to be followed remotely, allowing patients to access health services wherever, whenever and as often as they want. It is stated that well-structured mobile applications have a positive impact on the health sector. In this context, it is seen that the use of mobile applications in primary, secondary and tertiary healthcare services is becoming increasingly common all over the world.

In researches planned study, it is aimed to develop a mobile application in Turkish in order to raise awareness about cervical cancer and to evaluate its effectiveness. In the content of the mobile application to be developed, information about cervical cancer such as information about cervical cancer, symptoms, findings, diagnosis, screening, treatment, practical explanations with video, frequently asked questions about the subject; It is planned to have interim notifications, reminders, pay attention warning messages. There are a limited number of practices related to cervical cancer awareness in the world. In Turkey, there is no e-health mobile application for cervical cancer awareness. Unlike the applications in the world; In the application, which is aimed to be developed in this study, there is an area where the participants can ask questions to the researcher from the "Request Support" section and there is a field. The information provided by mobile health applications was found to be educational, appropriate, original and on-site, and it was found useful to be reliable. Studies have shown that mobile health applications contribute to positive health outcomes.

The study conducted through the mobile health application developed to raise awareness about cervical cancer; It is thought that it is important in terms of raising the awareness of participants, easing the work-time burden of health personnel in this period, and reducing the cost of health care through early diagnosis and treatment, and will set an example for future studies. Positive outputs from the mobile application will allow the application to be used on national and international platforms.
The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions ( e.g. , nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared,  e.g. , by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.
Chromosomal translocation of the MLL (Mixed-Lineage Leukemia) gene is observed for infant leukemia and some poor-prognosis leukemia cases. MLL, as a result of chromosomal translocation, fuses with 70 or more various translocation partner genes at the amino terminus thereof to express an MLL fusion protein. Wild-type MLL constructs a transfer regulation complex that modifies the chromatin structure, and specifically methylates lysine at position 4 of histone H3, playing a very important role in the transcription regulation of gene clusters (for example, HOX gene cluster, etc.) involved in hematogenesis and neogenesis. Meanwhile, the MLL fusion protein, the expression thereof being induced by chromosomal translocation, has lost the histone methylation enzyme activity, but activates gene clusters (for example, HOX and MEIS1 genes, etc.) involved in the cell differentiation control permanently. As a result, abnormal cell proliferation and inhibition of differentiation induction of hematopoietic cells are triggered, which leads to onset of leukemia. Leukemia involving a mutant MLL gene has poor prognosis, and the standard treatment used for leukemia treatment today does not demonstrate full effectiveness. For this reason, the development of new regimen of therapy is in strong demand. Menin is a tumor-suppressor protein identified as a causal factor of multiple endocrine neoplasia type 1 (MEN1), which is one of autosomal dominant inherited neoplasia syndromes, characterized by the tumor formation in multiple endocrine organs. Menin is a ubiquitously expressed nucleoprotein, interacts with a wide variety of proteins, and is involved in various cellular processes. It is considered that the biological functions of menin can be tumor-suppressing or tumor-promoting, depending on the cell context. Menin interacts with the amido terminus of MLL1, and functions as carcinogenic cofactor that increases the transcription of gene clusters such as HOX and MEIS1. It is known that the interaction between menin and an MLL fusion protein is essential for abnormal activation of a series of gene clusters and onset of leukemia caused by the MLL fusion protein (non-patent documents 1 and 2). Thus, it is expected that inhibition of the interaction between menin and an MLL fusion protein contributes to the treatment and/or prevention of leukemia involving MLL gene chromosomal translocation and other leukemia/hematological cancer accompanied by constant expression of HOX and MEIS1 genes. Accordingly, for example, the creation of a drug that inhibits the interaction between menin and an MLL fusion protein is of great significance from the perspective of providing a novel option for cancer treatment. A plurality of compounds are already known to exhibit inhibitory activity against the interaction between menin and an MLL protein (patent documents 1 to 4, non-patent documents 3 to 5).
Metal-based nanomaterials have remarkable bactericidal effects; however, their toxicity cannot be disregarded. To address this concern, we developed a simple synthesis route for antibacterial catheters using metal-based nanomaterials to reduce toxicity while harnessing their excellent bactericidal properties. The grafting agent (3-aminopropyl)triethoxysilane (APTES) forms -NH2 groups on the catheter surface, onto which copper ions form a nanomaterial complex known as Cu2(OH)3(NO3) (defined as SA-Cu). The synthesized SA-Cu exhibited outstanding contact antibacterial effects, as observed through scanning electron microscopy (SEM), which revealed cell membrane crumbing and bacterial rupture on the catheter surface. Furthermore, SA-Cu exhibited excellent biosafety characteristics, as evidenced by the cell counting kit-8 (CCK-8) assay, which showed no significant cytotoxicity. SA-Cu demonstrated sustained antimicrobial capacity, with in vivo experiments demonstrating over 99% bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA) for two weeks. The transcriptome sequencing results suggested that SA-Cu may exert its bactericidal effects by interfering with histidine and purine metabolism in MRSA. This study presents a straightforward method for synthesizing antimicrobial silicone catheters containing copper nanomaterials using copper ions.
Blood transfusions have many risks including transfusion reactions and infections. Cord blood is accepted as an alternative method for red cell transfusions in low-birth weight (LBW) premature newborns. However, experience and scientific evidence concerning in-vivo efficacy and safety of red blood cell (RBC) concentrates derived from cord blood in very LBW premature newborns is still insufficient.

A total of 50 umbilical cord blood (UCB) collected from infants born before 32 weeks' gestational age and processed into autologous RBC products. Infants requiring blood transfusion were randomly assigned to an autologous or allogeneic product. Two randomized groups were compared on the 14th, 28th, 35th days and \>35th days with respect to hemoglobin levels, transfusion numbers, transfusion and phlebotomy volumes, and hemoglobin, reticulocyte counts and erythropoietin levels in the postconceptional 36th and 40th weeks' gestation, and hemoglobin levels at postnatal 6-months age. All transfused infants were developmentally assessed by the end of the postnatal first year.
Dysphagia, dysphonia, and loss of cervical range of motion (ROM) are common complications after anterior cervical spine surgery, specifically anterior cervical discectomy and fusion (ACDF). Despite their clinical importance, studies on the treatment and/or prevention of these complications are limited due to the lack of valid and reliable outcome measures. The majority of research is found in the otolaryngology literature and has focused on disease pathophysiology, diagnosis, and therapy.

Dysphagia and dysphonia are widely measured by patient self-reported questionnaires, including the MD Anderson Dysphasia Inventory and SWAL-QOL. However, these validated outcome tools are cumbersome to complete and, therefore, have not been widely accepted into clinical practice, including in postoperative ACDF patients. The Bazaz score, a subjective questionnaire that has not been validated in the literature, has also been used to evaluate dysphagia after ACDF. Assessment using the Bazaz score is based on clinical examination, with the surgeon listening to the patient's voice and documenting hoarseness in the post-operative period. Recently, new patient-centered outcomes, the Eating Assessment Tool (EAT-10) and Voice Handicap Index (VHI-10) have been developed. Both EAT-10 and VHI-10 have excellent validity and reliability in evaluating dysphagia and dysphonia, respectively, in post-operative ACDF patients and can be used to document the initial dysphagia or dysphonia severity and monitor the treatment response in people with a wide array of swallowing and voice disorders. However, these methods of evaluating dysphagia and dysphonia alone offer limited information about the severity and characteristic of dysphagia or dysphonia and do not provide continuous monitoring of swallowing or speaking function throughout the post-operative period.

The wearable sensors under investigation in this study offer a novel, noninvasive, and easy-to-use way to monitor dysphagia, dysphonia, cervical ROM, and overall recovery progress in post-operative ACDF patients. Previous testing has demonstrated the ability of our sensors to monitor vital signs (including heart rate and respiratory rate), swallow count, talking time, energy expenditure, cervical neck movement, and body orientation. Sensor-measured swallow count and talking time, in conjunction with EAT-10 and VHI-10 scores, can provide a comprehensive view of the progression of dysphagia and dysphonia. Cervical neck movements measured by the sensor can enable continuous assessment of cervical ROM. Other general metrics captured by the sensors, including heart rate, respiratory rate, energy expenditure, and body orientation can provide other meaningful measures of recovery in post-operative ACDF patients. These sensors have also received positive feedback from patients and physicians on their comfort, ease of use, and application, further demonstrating the potential value of these sensors in improving the quality of post-operative care for ACDF patients.