anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition containing genipin for preventing or treating breast cancer is provided to suppress breast cell invasion. CONSTITUTION: A pharmaceutical composition for preventing or treating breast cancer contains genipin as an active ingredient. The pharmaceutical composition additionally contains an anticancer material or apoptosis inducer. The anticancer material is a cancer cell-specific antibody, a nucleic acid molecule which specifically suppresses expression of an anticancer gene, 5-fluorouracil, methotrxate, or doxorubicin. The antibody is a monoclonal antibody, a polyclonal antibody, a chimera antibody, a humanized antibody, or human antibody. A health food for treating breast cancer contains genipin as an active ingredient. [Reference numerals] (AA) Cell survival rate(% with respect to a control group); (BB) Genipin
This arm involves Robust Vocabulary Instruction, an explicit approach that emphasizes multiple and rich encounters in authentic contexts to promote depth of semantic knowledge of 20 words that pertain to scientific practices applicable to the FOSS lessons. The children receive a cumulative exposure of at least 20 times per word (a minimum of 5 times per each of four lessons) and at least 4 chances to produce the word (a minimum of 1 chance per each of four lessons).
Participants will use COMPLETE Multi-Purpose Solution to clean their contact lenses daily for 3 months. Participants will use Sensitive Eyes Rewetting Drops as needed during the study.
This study evaluates a recently piloted, self-administered, computerized tool for reducing prenatal drinking that added novel components of drink size assessment and drink size feedback to traditional screening and brief intervention (SBI). The bilingual (English and Spanish) electronic SBI or "e-SBI" will be adapted for use with non-pregnant women and a small trial of its efficacy will be conducted in two public health clinics. The effects of drink size assessment by itself and of depression as a modifier of e-SBI efficacy will also be studied. Study findings will help design a larger trial of e-SBI's efficacy for reducing prenatal alcohol use.

An experimental design will be used for the proposed small trial. Two hundred women, who have not been pregnant in the past year and report alcohol at risky levels will be randomly assigned to e-SBI or usual care. Participants will complete baseline, 3-month and 6-month follow-up assessments. These assessments will examine drinking and pregnancy as well as possible negative outcomes, such as increased drug use associated with the e-SBI. To address methodological limitations in prior research, the study design incorporates drink size assessment to better measure drinking outcomes, minimizes assessment reactivity for controls at baseline, and includes a booster e-SBI at the 3-month follow up. This allows for the examination of whether drink size assessment reduces drinking by itself and if its effects are equivalent to that of the full e-SBI. With these design innovations, the study is expected to provide information that can be more rigorously assessed in a subsequent multi-arm trial. Because it sets the stage for a Phase II trial of e-SBI efficacy for reducing prenatal alcohol use, our proposed study is of significance for improved maternal and child health. Findings will also impact the larger intervention literature on cost-effective strategies to reduce alcohol-related harm.
A pharmaceutical product is prepared from a pharmaceutically effective powder, e.g. a pulverized urea formic iodide and an organic liquid, e.g. a low-boiling petrol ether, ketone or acetate or a low-boiling halogenated hydrocarbon, e.g. a chlorinated and fluorinated hydrocarbon.ALSO:A method of preparing a pharmaceutical product comprises the steps of subjecting a pharmaceutically effective powder together with an organic liquid to serve as a carrier for the powder, to the action of a vibratory mill, Fig. 1 (not shown) and injecting the slurry produced into a container under pressure wherein the organic liquid serves as a pressurised propellant or as a constituent of a propellant for dispensing the liquid from the container.  The extra propellant is added to the slurry after grinding e.g. prior to the slurry being injected into the container.  A sample is taken of the slurry immediately after grinding.  The slurry is fed after grinding to a reservoir (18) Fig. 1 (not shown) and is fed from the reservoir to an injection apparatus, Fig. 2 (not shown) for injecting measured quantities of the slurry into pressured dispensing containers.  The slurry may be injected into a closed pressurised dispensing container by reverse flow through the valved head of the container.  A modified apparatus is described Fig. 3 (not shown) including two grinders. The powder may be pulverized urea formic iodide and the organic liquid a low boiling petrol ether, ketone or acetate or a low boiling halogenated hydrocarbon, e.g. a chrlorinated and fluorinated hydrocarbon.
PURPOSE: Glioma-associated epilepsy affects a significant proportion of glioma patients, contributing to disease progression and diminished survival rates. However, the lack of a reliable preoperative seizure predictor hampers effective surgical planning. This study investigates the potential of Alpha B crystallin protein (CRYAB) plasma levels as a predictive biomarker for epilepsy seizures in glioma patients.
METHODS: Plasma samples were obtained from 75 participants, including 21 glioma patients with pre-operative epilepsy, 14 glioma patients without pre-operative epilepsy, and 21 age- and sex-matched control subjects. Additionally, 11 idiopathic epilepsy patients and 8 intractable epilepsy patients served as positive disease control groups. The study utilized ELISA to accurately quantify the circulating levels of CRYAB in the plasma samples of all participants.
RESULTS: The analysis revealed a significant reduction in plasma CRYAB levels in glioma patients with pre-operative epilepsy and idiopathic epilepsy. The receiver operating characteristic (ROC) curve analysis displayed an impressive performance, indicating an AUC of 0.863 (95% CI, 0.810-0.916) across the entire patient cohort. Furthermore, plasma CRYAB levels exhibited a robust diagnostic capability, with an AUC of 0.9135, a sensitivity of 100.0%, and a specificity of 73.68%, effectively distinguishing glioma patients with preoperative epilepsy from those without epilepsy. The Decision Curve Analysis (DCA) underscored the clinical relevance of plasma CRYAB levels in predicting pre-operative epilepsy in glioma.
CONCLUSION: The findings imply that the reduced levels of CRYAB may assist in prediction of seizure occurrence in glioma patients, although future large-scale prospective studies are warranted.
Breast cancer is the most commonly diagnosed cancer among African American women in the United States, and in North Carolina (NC), African American women are more likely to die from breast cancer compared to women of other races/ethnicities. Given this disparity and with approximately 90,000 African American breast cancer survivors in NC, it is important to identify modifiable factors that can help improve survival among this population. Behavioral interventions that promote weight management among breast cancer survivors can help reduce risks for prevalent comorbidities, such as cardiovascular disease and diabetes, and potentially improve prognosis and survival. While lifestyle interventions have shown promise in improving body weight in breast cancer survivors, none have focused on weight gain prevention in African American breast cancer survivors, nor evaluated the use of frequent self-weighing as a self-regulation strategy.

Regular self-weighing has been effectively used as an approach for weight maintenance that helps individuals monitor daily weight fluctuations and make small changes in energy balance behaviors. Given that the frequency of self-weighing among breast cancer survivors is unknown, and the importance of self-regulation behaviors for weight maintenance is well established, extending previous work to prevent weight gain among breast cancer survivors is a critical next step for optimizing cancer outcomes. It is unknown whether self-weighing and activity monitoring is a feasible strategy for breast cancer survivors to monitor weight changes and regulate their energy balance. Thus, this three-arm, pilot randomized controlled trial will evaluate two behavioral self-regulation interventions for weight gain prevention (self-regulation or self-regulation plus activity monitoring) compared to a delayed control group among 45 female African-American post-treatment breast cancer survivors. Participants will be randomly assigned to one of three groups: Self-regulation intervention with activity monitoring (n=15); Self-regulation intervention (n=15); and Delayed control (n=15).
The invention discloses application of circSLC8A1 in preparation of a medicament for treating chronic kidney disease, wherein the nucleotide sequence of the circSLC8A1 is shown as SEQ ID NO. 1. The first time the use of CircSLC8A1 and its cognate mouse CircSLC8A1 for the treatment of CKD renal interstitial fibrosis was proposed. Overexpression of circSLC8A1 reduces the extent of pathological damage to the kidneys and the extent of fibrosis in the renal interstitium by reducing the EMT-related index and the expression of COL 1. In vivo overexpression of circSlc8a1 significantly reduced the extent of mouse renal interstitial fibrosis unilateral ureteral obstruction (UUIO) and unilateral renal ischemia reperfusion (UIRI) model mouse renal interstitial fibrosis. The circSLC8A1 is expected to be used as a drug target for delaying the progress of CKD and improving prognosis and a new target for anti-fibrosis treatment.
The aim of this study was to investigate how self-rated health (SRH) reflects ongoing ill-health and how SRH is associated with previous ill-health and/or predicts future ill-health such as burnout, disturbed sleep, and somatic symptoms. The study used two waves from the population-based Västerbotten Environmental and Health Study in which 2 336 adult persons participated by answering a questionnaire at two time points three years apart. Hierarchical and logistic regression analyses were conducted, thus treating all variables both continuously (degree) and categorically (case). The analyses were performed both cross-sectionally and longitudinally. The results showed bidirectionality between suboptimal SRH and burnout, disturbed sleep and somatic severity caseness. Moreover, degree of poor SRH was more likely to occur simultaneously to high degrees of burnout and somatic severity than to degree of poor sleep quality. Also, caseness of burnout, disturbed sleep and somatic severity increased the risk of simultaneous suboptimal SRH. Finally, the results showed that degree of burnout three years earlier, predicted degree of poor SRH, and that degree of poor SRH predicted degree of sleep three years later. In conclusion, in a population-based, normal adult sample there is a bidirectional relationship between suboptimal SRH and caseness of burnout, disturbed sleep quality and somatic symptoms, but not between degree of these symptoms. The results can have implications for health care meeting patients complaining about poor general health.
A release particle composition for forming a release particle, having a mixture of an organic solid, a non-volatile silicone, and a cosmetic ingredient that is different than the organic solid and the non-volatile silicone. The organic solid is a fatty ester, a fatty ether, or a fatty alcohol. Each release particle has a softening point of about 32°C to about 60°C. The cosmetic ingredient is present at up to about 80wt% based on the total weight of the composition. The organic solid is present at about 10wt% or more based on the weight of the composition. The non-volatile silicone is present at about 10wt% or more based on the total weight of the composition.
The hernia is defined as the passage of an organ or tissue from one anatomical region to another. Hernia sacs are sent to the pathology department, although there is a difference between clinics. Routine microscopic examination of the hernia sac is controversial. While some centers do not recommend a routine microscopic examination in inguinal hernias in adult patients, they recommend them in abdominal wall hernias. Here, the investigators aimed to discuss the pathology results and unexpected histopathological findings who underwent abdominal wall and inguinal hernia operation in the light of the literature. Patients who have operated hernia and sent hernia sac for histopathological examination were retrospectively screened. Emergency and elective operated patients were included. Hernia repairs without pathology were excluded from the study. Patients' gender, age, operation notes, and pathology results were analyzed. Pathology results were analyzed in two groups as expected findings and unexpected findings. In our study, the probability of encountering an unexpected pathological result was found to be quite low in the pathological evaluation of the hernia sac. Although it may cause additional workload and cost, all hernia sacs should be sent to routine pathological examination. The investigators believe that making savings in these areas through further investigation after the decision of the pathologist.
Nearly 1 million patients with atrial fibrillation (AF) who meet guideline criteria for anticoagulation (AC) are being left untreated, often due to providers over-estimating risks of bleeding and falling and under-estimating risks of stroke. The objective of this project is to improve rates of adherence to AC guidelines by creating supportive and educational materials for cardiology as well as primary care providers to evaluate the risks and benefits of prescribing AC to patients with AF. The investigators will email providers individual auto-updating reports containing their AC prescription rate compared to their peers and compared to practice level AC prescription goal. This report will also contain a list of the provider's AF patients who are eligible to receive AC based on their CHA2DS2-VASc stroke risk score ≥ 2 and a list of eligible AF patients with upcoming appointments to focus providers on an actionable group of patients with whom they might review the use of AC. The investigators will also message providers through the EHR prior to an upcoming appointment with an eligible patient reminding them to discuss AC if they deem appropriate. In addition, the investigators will directly engage with providers through academic teledetailing to educate providers on AC and address misconceptions and barriers to initiating or resuming AC in AF patients.
PURPOSE:To obtain a medicine, effectively used for patients reduced in blood platelets or leukocytes, especially thrombocytopenia, leukopenia or hematopoietic dysfunction caused by chemotherapy or radiotherapy for cancer and having high safety and unconventional hematopoietic hyperfunction. CONSTITUTION:The objective therapeutic agent for thrombocytopenia and/or leukopenia comprises conagenin expressed by the formula or its salt, especially a phermaceutically permissible salt with an alkali metal such as sodium or potassium or an alkaline earth metal such as calcium or an ammonium salt as an active ingredient. This therapeutic agent has ultralow toxicity. The administration form of this therapeutic agent is preferably any of an oral agent, an injection and a rectal suppository. The dose varies with the disease to be treated and its symptom; however, it is usually preferably 2mg to 2g, especially 20 to 200mg expressed in terms of the conagenin for an adult. Furthermore, the conagenin can be produced by using Streptomyces.roseosporus (FERM P-2738) which is an actinomyces according to a well-known method.
This is a multicenter, prospective, observational clinical study for validation of a radiopathomics artificial intelligence (AI) system. Patients who have been diagnosed with gastric adenocarcinoma by pathology and defined as clinical stage II-IVa without distant metastasis by enhanced CT scan will be enrolled from the Second Affiliated Hospital of Zhejiang University, the First Affiliated Hospital of Zhejiang University, Shangyu People's Hospital of Shaoxing City and Zhejiang Cancer Institute \& Hospital. All participants should adhere to a highly standardized treatment protocol, which involves receiving either 2-4 courses of standard neoadjuvant chemotherapy based on 5-FU + platinum, or 2-4 courses of neoadjuvant chemotherapy based on 5-FU + platinum combined with trastuzumab, or 2-4 courses of neoadjuvant chemotherapy based on 5-FU + platinum combined with anti-PD-L1 therapy. Following the neoadjuvant treatment protocol, participants will undergo a D2 radical gastrectomy for gastric cancer. The enhanced CT and biopsy examination should be completed before the nCRT and the images will be subjected to the manual delineation of the tumor regions of interest (ROI) by experienced radiologists and pathologists. Subsequently, the enhanced CT and biopsy images outlined will be used in the radiological pathology AI system to generate predicted responses (predicted postoperative TRG grading) for individual patients, while actual responses (confirmed postoperative TRG grading) will be diagnosed in surgical resection specimens. Through comparisons of the predicted responses and true pathologic responses, investigators calculate the prediction accuracy, specificity, sensitivity as well as the Area Under Curve (AUC) of Receiver Operating Characteristic (ROC) curves. The aim of this study is to verify the high accuracy and robustness of the radiological pathology AI system in predicting postoperative TRG grading in individuals before nCRT, which will promote further precise treatment of locally advanced cancer patients.
The goal of this systematic review and meta-analysis is to evaluate the perioperative and oncologic results of natural orifice specimen extraction (NOSE) compared to conventional transabdominal specimen extraction (TASE) in robotic-assisted surgery for colorectal cancer. A comprehensive electronic search will be performed on PubMed, Embase, and the Cochrane Library to find research articles published from the beginning of the databases to July 2024 that focus on patients who have undergone robotic-assisted surgery for colorectal cancer. Specifically, this review will compare NOSE with conventional TASE. Only studies published in English will be considered. Literature screening will adhere closely to predetermined criteria for inclusion and exclusion, specifically targeting randomized controlled trials and cohort studies. The evaluation of quality will involve the use of the Newcastle-Ottawa Scale (NOS). Meta-analysis of the included studies' data will be performed using Review Manager 5.4.1. In the final analysis, 9 retrospective cohort studies comprising 1571 patients were included. Out of these, 732 patients opted for NOSE, while 839 patients chose conventional TASE in robotic colorectal surgery. Patients who received TASE experienced enhancements in hospital stay duration, time until first gas passage, wound infection rates, and time until the first intake of a liquid diet. Nevertheless, there were no notable distinctions noted between the two methods regarding surgery duration, projected blood loss, intestinal blockage, or frequency of anastomotic leakage. In patients undergoing robotic-assisted colorectal surgery, the safety and feasibility of NOSE are demonstrated. Compared to traditional TASE, it provides clear benefits including shorter hospital stays, earlier first flatus, quicker initiation of a liquid diet, and lower risk of wound infection.
PURPOSE:A cosmetic capable of beautifying the skin free from removal by water, ect., consisting of ume brandy which is blended with oil of a bird under stirring. CONSTITUTION:Oil of a bird (e.g., chicken oil) is added to ume brandy and stirred, and, if necessary, blended with sarcocarp of completely powdered unripe ume, to give a cosmetic. Ume, e.g., an unripe ume, and crystal sugar are immersed in a low-class distilled spirits to prepare ume brandy. Sarcocarp of completely powdered unripe ume is added to the ume brandy, if necessary. The resulting mixed liquid is blended with a proper amount of bird oil to give the cosmetic. Ume brandy has an effect to smooth fine wrinkles, and bird oil formes a tough film on the skin, which is unremovable by water and provides a good feeling.
The utility model relates to a no pressing silver amalgam capsule of a heat-sealing mercury packet, which relates to a preparation used in the dentistry. The alloy silver powder and a heat-sealing mercury packet in which the mercury is packed by a plastic film is arranged in a plastic capsule. The utility model can be directly put on a silver mercury mixing machine to mix without the need of pressing. Then, severe vibration is produced. The mercury packet is extremely easy to open because of the impact. The mercury and the alloy silver powder are caused to mix sufficiently. The time and the labour are saved. Because the mercury packet is rigorously packed, the utility model can be stored for a long time, and the danger caused by the release of the mercury vapour can not happen. Thereby, the utility model has the advantage of high safety, and can be popularized in a dentistry clinic.
PA21 chewable tablets standardised to contain 500 mg of iron. PA21 500 mg (iron) chewable tablet contains approximately 2.5 g PA21 drug substance (sucroferric oxyhydroxide). Starting dose will be 1,500 mg/day (3 tablets/day (1 tablet per meal)). Dose increases or decreases of 500 mg/day (1 tablet/day) are permitted. The maximum dose of PA21 will be 3,000 mg/day (6 x 500 mg tablets/day) and the minimum dose will be 1,000 mg/day (2 x 500 mg tablets/day).
We propose to conduct a multifactorial genetic study of cancer risk-related behaviors and other complex human characteristics. The main areas of interest are tobacco smoking, excess alcohol consumption, psychological traits, and HIV/AIDS susceptibility and progression. The subjects will be adult male and female probands who display one or more of the phenotypes of interest together with their brothers, sisters and parents. Information on tobacco and alcohol use, psychological and personality traits, sexual behavior, HIV status and progression, and other characteristics with possible genetic components will be obtained through structured interviews and questionnaires. DNA will be prepared from blood samples and typed for a series of candidate genes chosen for function and for random polymorphic markers. By correlating the genotypic and phenotypic information, we hope to identify individual loci that interactively contribute to many different aspects of human health and disease.
Patients receive veliparib orally PO QD and cyclophosphamide PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Disclosed are articles useful in cleansing, and particularly wet-like cleansing wipes and toilet tissue. These articles are essentially dry to the touch prior to use, but deliver liquid when subjected to in-use shear and compressive forces. In one aspect, the articles of the present invention comprise a carrier and an emulsion applied to the carrier, the emulsion comprising a continuous external nonpolar phase and an internal polar phase dispersed in the external nonpolar phase, wherein the article is capable of retaining fluid prior to use. In another aspect, the emulsion-treated articles exhibit improved ability to release fluid when subjected to in-use pressures.  The articles of the present invention offer a number of significant advantages over prior cleaning products when in the form of wet-like cleansing wipes such as those used for cleaning of hardsurfaces (e.g., floors, countertops, sinks, bathtubs, toilets, and the like) and wet-like toilet tissue. The articles can in general be used in any applications requiring the delivery of polar materials, in particular water and water-soluble or dispersible actives.