anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Runting and stunting syndrome (RSS) is an enteric viral disease in commercial poultry that directly affects gut health; however, its influence on gut microbiota remains unknown. This study aimed to investigate the compositional changes in the bacterial community of the ileum of 7-day-old broiler chicks naturally affected or not affected by RSS, using next-generation sequencing (NGS) technology. Twenty-one samples were obtained from the ileal contents and mucosa of 11 chicks with RSS and 10 healthy chicks, raised in a dark house system located on a farm in the state of Minas Gerais, Brazil. The results revealed overall changes in the gut microbiota of the chicks with RSS, including a decrease in microbial richness and diversity. In particular, there was a decrease in Lactobacillus and an increase in Candidatus Arthromitus and Clostridium sensu stricto 1. These results indicate a relationship between viral infection and the gut microbial composition, which can cause gut dysbiosis and may influence inflammation in this organ.RESEARCH HIGHLIGHTS RSS causes dysbiosis of the gut microbiota of the ilea of chicks.A difference was found in gut microbiota between chicks with or without RSS.Candidatus Arthromitus was predominant in chicks with RSS.Clostridium sensu stricto 1 was strictly associated with chicks with RSS.
Many patients diagnosed with Early Rectal Cancer (ERC) are currently over-treated. Most patients with confirmed ERC will undergo an MRI, but some are not correctly identified in endoscopy and immediately removed. Of those who undergo MRI, 69% are over-staged and undergo major surgery or unnecessary radiotherapy when local excision surgery to preserve the patients rectum, and quality of life, would have been possible. \<10% of patients with ERC are staged accurately and offered local excision, with the majority who are staged as ERC on MRI still undergoing major surgery, likely due to uncertainty in the staging report.

Prof Gina Brown developed a more accurate radiological staging system (PRESERVE) or ERC, whereby T2 tumours are identified and classified according to the degree of preservation of the individual layers of the rectal wall. It has been shown that PRESERVE enabled better identification of ERC suitable for local excision from the expected 30% to 89% accuracy. This improved accuracy was replicated in a further study by training a cohort of 12 radiologists. It is predicted that wider adoption of PRESERVE will result in increased organ-preserving surgery from the current rates of 10% to \>50%.
Background: Hematologic conditions such as hereditary spherocytosis, sickle cell disease, and idiopathic thrombocytopenic purpura are frequently linked to cholelithiasis. In instances where symptoms are present, simultaneous cholecystectomy and splenectomy are commonly recommended. Our aim was to assess the outcomes of robotic-assisted procedures conducted for simultaneous surgical issues involving the spleen and gallbladder in pediatric patients. Materials and Methods: We have made a simultaneous retrospective study of children with hereditary hematological diseases who underwent combined robotic-assisted splenectomy and cholecystectomy at our institution from January 2010 to December 2021. Demographics, clinical features, intraoperative data, length of hospital stay, postoperative complications, and follow-up outcomes were analyzed. Results: A total of 11 patients (6 male; 5 female) were included, with a mean age of 13.9 ± 4.4 years (range 8-17). Hereditary spherocytosis was the most common disease (7 cases), followed by sick cell disease (4 cases), with associated symptomatic gallbladder litiasis in all of them. Both operations were carried out using the da Vinci® Surgical Si System in a single docking robotic platform (four robotic arms). Median total surgery time was 145 minutes (Q1-Q3: 115-162). Minimal intraoperative bleeding was recorded (mean 45 ± 15 mL), with no intraoperative complications or conversion. Median length of hospital stay was 3 days (Q1-Q3: 2-4). There were no cases of surgical wound infections or postoperative bleeding documented. Conclusion: Simultaneous robotic-assisted splenectomy and cholecystectomy can be considered safe and feasible interventions in children with hematological diseases that affect both the spleen and the gallbladder. However, further research is needed to enhance the existing evidence and establish a standardized approach.
The invention belongs to food products; precisely, emphasizing special purpose food supplements. The purpose of the invention is to expand the supplement's usage indications, to improve its stability and increase efficiency. The food supplement consists of the following elements in grams: dense propolis extract 40, ascorbic acid 5, and natural honey up to 1,000. Crystallized honey is heated in the reactor up to 35 degrees; 5 grams of ascorbic acid inserted and 40 grams of dense propolis extract are added in small portions. The produced mass is dispensed in containers and kept for 2 days at 10 - 12 degrees. This food supplement is used to cure and prevent immunostimulator diseases.<IMAGE>
The invention discloses a medicament for treating angiitis which belongs to the Chinese traditional medicine field. The medicament for curing angiitis is prepared by following compositions by weight: angelica, Astragalus root, hemlock parsley, radix clematidis, red sage root, cassia twigs, frankincense, dandelion, achyranthes, safflower and asarum. The crude drugs are mixed in a bellied stew pan and are soaked totally by adding adequate water; the materials are fried to boil by large fire and then is fried by soft fire for half an hour, the liquid medicine is filtered off, and adequate water is added in the dregs of a decoction for second frying for half an hour, then the liquid medicine is filtered off again. The two times of liquid medicine mixing and cooling are at half an hour before breakfast and half an hour after supper. The invention adopts the formula that light and severe patients can get good treatment after taking the medicine in the clinical treatment; and the illness state and pain of acute necrosis patients can be controlled and released after taking the medicine, thereby greatly encouraging patients. The clinical observation shows that: severe patients with partially necrotic limbs can have the necrotic parts shedding off automatically in about six months and being healed with the total effectiveness ratio reaching 98.33 percent.
PURPOSE:To provide a new tetrahydrobenzazepine derivative having excellent arginine vasopressin antagonistic actions such as water diuretic action, urea secretion promoting action, factor VIII secretion suppressing action, vasodilating action and cardiac function promoting action and useful as an antagonist for arginine vasopressin. CONSTITUTION:The tetrahydrobenzazepine derivative of formula I [R is formyl or group of formula IV (one of R<1> and R<2> is H and the other is alkoxy, alkoxycarbonyl or phenyl); R<3> is H or alkyl], e.g. (E)-5-methoxymethylidene-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-t etrahydro-1H-benzazepine. The compound of formula I, e.g. the compound of formula Ia can be produced by reacting a compound of formula II with a phosphonium salt of formula III a (X is halogen) or phosphonate of formula IIIb (R<4> is alkyl). The compound is useful as a water diuretic agent, urea secretion promoting agent vasodilator, hypotensor, agent for cardiac insufficiency, agent for renal failure, blood coagulation suppressing agent, etc.
The present invention relates to a carrier of livestock and poultry castration vaccine genes and recombination genes, which belongs to the hi-tech field of biotechnology. The carrier of castration vaccine genes and recombination genes is used for producing subunit vaccines of castration gene engineering of livestock and poultry. A preparation method comprises the following steps: LHRH gene segments for livestock or poultry or both livestock and poultry are artificially synthesized, wherein NcoI and XhoI restriction enzyme sites are added to the 5' end and the 3' end of the LHRH gene segments; pET-32c plasmid is inserted into the LHRH gene segments so as to construct 4 kinds of pET-32c-LHRHn-N/X recombinant plasmid for expressing LHRH-Trx fusion protein; the recombinant plasmid is converted into escherichia coli BL21(DE3). The product of the expression is soluble protein. The present invention with convenience of extraction and purification and effective castration can be used by both livestock and poultry and can be used for immunizing animals, such as chickens, pigs, sheep, rabbits, dogs, cats, etc. The construction of the recombinant plasmid of pET-32c-LHRHn(L1, L2, L3, L4)-N/X is disclosed in the specification.
The patients will be instructed to irrigate once daily at a fixed time for 6 weeks. The patients will be instructed to use the irrigation 30 min after breakfast, capitalizing on the gastrocolic response; however, should this not fit in with the individual's lifestyle, then an alternative time of the day may be used. Preferably shortly after a large meal. The patients should fill the pump with 180 milliliters (a full pump) and irrigate with a volume of 160 milliliters of water.
SARS-CoV-2, the causative agent of COVID-19, can infect various tissues in the body apart from the lungs. Although placental infection remains controversial, COVID-19-associated placental abnormalities have been reported worldwide. Therefore, COVID-19 poses a significant risk for fetal distress as well. Scientists are currently debating whether such distress results from direct viral induced assault or placental damage caused by the mother's immune response. The placenta develops different histopathological lesions in response to maternal SARS-CoV-2 infection. While some studies support both theories, the transmission rate through the placenta remains low. Therefore, a more in-depth study is necessary to determine the primary cause of maternal SARS-CoV-2-induced fetal distress. This comprehensive review is aimed to shed light on the possible reasons towards fetal distress among mothers with COVID-19. This review describes the various mechanisms of viral entry along with the mechanisms by which the virus could affect the placenta. Reported cases of placental abnormalities and fetal distress symptoms have been collated to provide an overview of the current state of knowledge on vertical transmission of COVID-19.
Patients undergo standard of care hormone therapy and radiation therapy as in Arm I. Patients also receive apalutamide PO QD on days 1-90. Cycles repeat every 90 days for 8 cycles in the absence of disease progression or unacceptable toxicity.
The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by type I allergy and evaluates type III allergy inflammation individually, and a method of screening a reaction accelerating or inhibitory substance in a type III allergy reaction through Fc .gamma. RIII by using said experimental model animal. In order to eliminate Fc .gamma. RIIB that demonstrates suppressive action to response through Fr .gamma. RIII, a mouse wherein the deletion mutation of both molecules of Lyn and Fc .gamma. RIIB are homozygotic (Lyn-IIB-) was generated by mating Lyn knockout mouse (Lyn-/-) and Fc .gamma. RIIB knockout mouse (Fc .gamma. RIIB-/- ), and was used to measure and evaluate the deficiency of Fc .gamma. RIII function in systemic passive anaphylaxis and the reduction of Fc .gamma. RIII function in a bone marrow-derived mast cell, or the like.
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide, and endoplasmic reticulum stress (ERS) and mitochondrial Ca2+ overload have been involved in apoptotic cardiomyocyte death during MI. 13-Methylpalmatine (13-Me-PLT) is a natural isoquinoline alkaloid isolated from Coptis chinensis and has not been systematically studied for their potential pharmacological effects in cardiovascular diseases. We conducted the present study to elucidate whether 13-Me-PLT modulates MI pathology in animal MI and cellular hypoxic models, employing state-of-the-art molecular techniques. The results demonstrated that 13-Me-PLT preserved post-ischemic cardiac function and alleviated cardiomyocyte apoptosis. 13-Me-PLT decreased ERS and the communication between ER and mitochondria, which serves as a protective mechanism against mitochondrial Ca2+ overload and structural and functional injuries to mitochondria. Our data revealed mitigating mitochondrial Ca2+ overload and apoptosis by inhibiting CHOP-mediated Ca2+ transfer between inositol 1,4,5-trisphosphate receptor (IP3R) in ER and VDAC1 in mitochondria as an underlying mechanism for 13-Me-PLT action. Furthermore, 13-Me-PLT produced superior effects in alleviating cardiac dysfunction and apoptosis post-MI to diltiazem and palmatine. Collectively, our research suggests that the CHOP/IP3R/VDAC1 signaling pathway mediates ER-mitochondrial Ca2+ transfer and 13-Me-PLT activates this axis to maintain cellular and organellar Ca2+ homeostasis, protecting against ischemic myocardial injury. These findings may offer an opportunity to develop new agents for the therapy of ischemic heart disease.
Over the last three decades, what is referred to as Brugada syndrome (BrS) has developed from a clinical observation of initially a few cases of sudden cardiac death (SCD) in the absence of structural heart disease with ECG signs of "atypical right bundle brunch block" to a predominantly electrocardiographic, and to a lesser extent genetic, diagnosis. Today, BrS is diagnosed in patients without overt structural heart disease and a spontaneous Brugada type 1 ECG pattern regardless of symptoms. The diagnosis of BrS is less clear in those with an only transient or drug-induced type 1 Brugada pattern, but should be considered in the presence of an arrhythmic syncope, family history of BrS, or family history of sudden death. In addition to survived cardiac arrest, syncope is probably the single most decisive risk marker for future arrhythmias. For asymptomatic BrS, risk stratification remains challenging. General recommendations to lower the risk in BrS include avoidance of drugs/agents known to induce and/or increase right precordial ST-segment elevation, including treatment of fever with antipyretic drugs. Several ECG markers that have been associated with an increased risk of SCD have been incorporated into a recently published risk score for BrS. The aim of this article is to provide an overview of the status of risk stratification and to illustrate open issues und gaps in evidence in BrS.
The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of the combination of two different experimental HIV vaccines-the DNA-HIV-PT123 vaccine and the AIDSVAX® B/E vaccine-administered in different sequences or simultaneously, in healthy adults who are not infected with HIV.

Participants will be randomly assigned to four groups. Depending on which group participants are in, they will receive different combinations of the DNA-HIV-PT123 vaccine, the AIDSVAX® B/E vaccine, a placebo for DNA-HIV-PT123 vaccine, and/or a placebo for AIDSVAX® B/E vaccine. Study visits will occur at study entry, Week 2, and Months 1, 1.5, 3, 3.5, 6, 6.5, 9, and 12. All participants will receive their assigned combinations of vaccines at study entry and Months 1, 3, and 6. At each vaccination visit, participants will receive one injection in each upper arm. Following each vaccination, participants will remain in the clinic for 30 minutes for monitoring. All study visits will include a physical examination, HIV risk reduction counseling, and questionnaires and assessments. Select study visits will also include a urine collection, a blood collection, a pregnancy test for participants who were born female, and HIV testing and counseling.
BACKGROUND: Regional block, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), or serratus anterior plane block (SAPB) has been recommended to reduce postoperative opioid use in recent guidelines, but the optimal options for intraoperative opioid minimization remain unclear. The aim of this study was to evaluate the intraoperative opioids-sparing effects of three regional blocks (TEA, TPVB, and SAPB) in patients undergoing video-assisted thoracoscopic surgery (VATs).
METHODS: This was a retrospective study of the adults undergoing VATs at a tertiary medical center between January 2020 and February 2022. According to the type of regional block used, patients were classified into 4 groups: GA group (general anesthesia without any regional block), TEA group (general anesthesia combined with TEA), TPVB group (general anesthesia combined with TPVB), and SAPB group (general anesthesia combined with SAPB). Cases were matched with a 1:1:1:1 ratio for analysis by age, sex, ASA physical status, and operation duration. The primary outcome was the total intraoperative opioid consumption standardized to Oral Morphine Equivalents (OME). Multivariable linear regression was used to estimate the association of the three regional blocks with the OME.
RESULTS: A total of 2159 cases met the eligibility criteria. After matching, 168 cases (42 in each group) were included in analysis. Compared with GA without any reginal block, the use of TEA, TPVB, and SAPB reduced the median of intraoperative OME by 78.45 mg (95% confidence interval [CI], -141.34 to -15.56; P = 0.014), 94.92 mg (95% CI, -154.48 to -35.36; P = 0.020), and 11.47 mg (95% CI, -72.07 to 49.14; P = 0.711), respectively.
CONCLUSIONS: The use of TEA or TPVB was associated with an intraoperative opioid-sparing effect in adults undergoing VATs, whereas the intraoperative opioid-sparing effect of SAPB was not yet clear.
Providing aquilaria sinensis (Thymelaeaceae, aquilaria) of Aquilaria Aquilaria    sinensis (Lour.)Spreng.]Pericarp extract (PGB-B), pharmaceutical composition thereof, preparation method thereof, and application thereof in preparing medicine for treating psoriasis. Belongs to the technical field of medicines. The invention extracts the dried aquilaria sinensis peel by using aqueous ethanol and prepares PGB-B by utilizing the water solubility difference. In the imiquimod-induced mice model of psoriasis, the score of the psoriasis skin lesion area and severity index (PASI) is obviously reduced, the skin thickness is reduced, and the spleen is reduced after PGB-B treatmentThe dirty coefficient is reduced, and the obvious treatment effect is shown. PGB-B and its various combinations are new options for the treatment of psoriasis.
As part of the unit that specializes in eating disorders in adolescents, we see patients decreased taste and smell sensory abilities. Since 2006, we have implemented various sensory workshops: olfactory, tactile-kinesthetic and auditory. The establishment of this therapeutic practice that is centered on oral sphere and all respect, it was observed a decrease of 30% of the length of hospitalization. All the data we currently have in the field, suggests a rehabituation food odors and facilitate the recall of memories related to food in anorexic patients. However in the literature the use of olfactory dimension in the treatment of anorexia has not been verified experimentally. The investigator hypothesize that the therapeutic use of a dietary nature olfactory stimuli in anorexia nervosa promotes food recovery. The team propose a prospective study over a period of 12 months in which we use the Body Mass Index (BMI) as the primary endpoint of the state of anorexia nervosa patients.
FIELD: medicine. SUBSTANCE: composition has at least one oxidation predecessor in a medium appropriate for staining and, when required, one or several dye- forming agents. The composition additionally has non-ionic amphiphilic polymer having at least one hydrophilic link. The method involves applying the composition. EFFECT: reduced dye consumption; large set of colors. 28 cl
FIELD: medicine, gynecology. SUBSTANCE: topography of tubal obstruction is preliminarily determined by hysterosalpingography and bimanual vaginal inspection. Then distal end of light guide is deeply inserted into vaginal fornix tissues to approach necessary tubal part. Irradiation is conducted by helium-neon laser for 2-4 min at cyclic fluctuation of incoming power density ranged 20-60 milliwatt/cmcm 2  at first and vice versa at corresponding energy density of 2.4-7.2 J/cmcm 2  at 1-2 hertz frequency for 5-7 seances. Then treatment should be conducted in a day at incoming power density ranged 1-10 milliwatt/cm cm 2 and vice versa at energy density of 0.1-1.2 J/cm cm 2 at the same frequency for 6-8 seances by alternating with tubal hydrobougienage at 120-130 mm mercury column pressure using novocaine, kanamycine, lidase for 6-8 procedures. EFFECT: higher efficiency in treating female tubal infertility. 3 tbl
Virtual Diabetes Prevention Program: All participants will view the 16 Comcast on Demand episodes, weigh themselves, and track their progress weekly. Participants in the VOD arm of the study received access to a paper tracker to track food and activity during the program.
BACKGROUND: We administered Bushen Huoxue Huazhuo Formula (BSHXHZF) and transplanted bone marrow mesenchymal stem cells (BMSCs) into mice with Wilson's disease (WD)-related liver fibrosis to evaluate the liver-protecting mechanism of this prescription.
METHODS: Mice, randomly divided into different treatment groups, showed histopathological changes and degree of hepatocyte apoptosis. For hepatic hydroxyproline (Hyp) determination, transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) mRNA and protein were measured. Chemical profiling of the extract of BSHXHZF using The liquid chromatography-mass spectrometry (LC-MS/MS) and revealing its antifibrosis mechanism using metabolomics.
RESULTS: TCM+BMSC group livers exhibited few inflammatory cells. TUNEL revealed abundant brown apoptotic cells in model control groups, while the TCM+BMSC groups showed a significant increase in blue negative expression of liver cells. Hyp in toxic milk (TX) mice groups was significantly lower than that in model control groups (MG). Compared with MG, TGF-β1 expression was significantly lower than all other groups, while BMP-7 expression was significantly higher. Metabolic analysis identified 20 potential biomarkers and 10 key pathways, indicating that BSHXHZF+BMSC intervention has a significant regulatory effect on metabolic disorders of these small molecule substances.
CONCLUSION: BSHXHZF combined with BMSCs can inhibit liver fibrosis and hepatocyte apoptosis by improving related metabolic disorders, and achieving therapeutic effects in WD-related liver fibrosis.