anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1312918 Veterinary treatment BEECHAM GROUP Ltd 6 July 1970 [8 July 1969] 34256/ 69 Heading A5B Mammary disorders in non-human animals are treated by administering an antibacterial agent in the form of sustained release beadlets to the animal by the intramammary route during the animals dry period. The antibacterial agent may be an antibiotic such as a penicillin or non-toxic salt or ester thereof such as cloxacillin, benzathine cloxacillin, ampicillin, carbenicillin; neomycin (especially the sulphate thereof) streptomycin, novobiocin, tetracycline, chlorotetracycline, oxytetracycline and salts thereof. The sustained release beadlets may be administered, particularly for the treatment of bovine mastitis, in the form of a suspension in an aqueous medium or an emulsifiable oily vehicle. The sustained release beadlets may consist of the antibacterial agent dispersed in a matrix of water-soluble or disintegrable protective material such as a waxy substance e.g. carnauba wax, montan wax, beeswax, glycerides such as hydrogenated castor oil and hydrogenated lard, fatty amides such as myristamide and stearamide. The matrix containing the antibacterial agent may be encapsulated with a further protective coating e.g. waxes with lower melting points than the primary matrix material such as paraffin wax and spermaceti wax, proteins such as gelatin, fatty alcohols such as stearyl and cetyl alcohol, glycerides such as glyceryl monostearate and lacquers.
[GB1312918A]
NEW MATERIAL:The polyoxyalkylene derivative of formula I (B is residue of a compound having 3-20 hydroxyl groups; AO is 2-18C oxyalkylene; R is 1-24C hydrocarbon group or acyl; a is even number of 2-18; b is 0-18; c is 0-18; b and c are not 0 at the same time; m is 1-100; n is 1-100). EXAMPLE:The compound of formula II. USE:Useful as a raw material for polyester and polyurethane and as a surfactant. It can be used also as a modifier for carbonyl compound such as perfumery. The activity of the perfumery can be maintained over a long period by the use of the modifier. PREPARATION:The compound of formula I can be produced by reacting a compound having 3-20 hydroxyl groups e.g. with formaldehyde in the presence of an acidic catalyst, adding an alkylene oxide to the product in the presence of an alkaline catalyst at 80-200 deg.C under <=10kg/cm<2> pressure and subjecting the addition reaction product to dehydration, etc.
The invention provides a medicine which is used for regulating liver, nourishing kidney, nourishing yin and reducing pathogenic fire and has significant improving function to the liver and kidney syndrome with yin asthenia belonging to menopausal syndrome TCM, hotness and red face, dizziness and tinnitus, soreness and weakness of waist and knees, heel pain, dreaminess, irritability, vaginal dryness or skin itching and the like, and a preparation method thereof. The medicine is prepared from five Chinese medicines, i.e. rehmannia, tortoiseshell plastic, cork (salt), anemarrhena (salt) and white peony root. Among the five Chinese medicines, the tortoiseshell plastic is crushed into fine powder for backup use. The anemarrhena is soaked by three times of 1 percent of phosphoric acid for 4h, added with water to 12 times and decocted for twice together with the rehmannia, the anemarrhena and the white peony root (1.5h for every time), the decoction is combined and filtered; when the filtrate is concentrated to 1.10 to 1.15 (50 to 60DEG C), ethanol is added in until the alcohol content is 70 percent; the intermediate product stays still overnight, and the supernatant fluid is recovered until the ethanol has no alcohol taste. Liquid medicine is added into the tortoiseshell plastic powder to be molten, the liquid medicine continues to be concentrated into extract with the relative density of 1.32 to 1.35 (50 to 60DEG C), is prepared into grains so as to prepare the granular preparation.
The study duration is approximately 2 hours per participant. First, the screening will be done and the participant does a warmup (\~30 min). After that, the participant gets ready for testing, which will last for approximately 90 minutes. In each test, the participants have trial rounds to familiarize with the test procedure. The testing consist of three different exercises, the isometric strength test (IsoMST), the maximum initial push propulsion (MIPP) and the sprint. In the IsoMST a pull setup which was already used in literature and a push setup which has yet to be validated will be used. For the pull setup, the chair of the athlete is fixated on the wall which results in a static situation and allows for an isometric effort. For the push setup, a bumper is installed on the wall, against which the athletes can push with their chair. Different grip position will be measured. In the MIPP test the participants are instructed to accelerate as quickly as possible from standstill with only one push on the rim. The MIPP will be executed with several different grip positions, equal to the IsoMST. For the sprint, 20m will be marked out on a playing court. The athletes are instructed to complete the distance as quickly as possible. Several split times as well as the total time will be measured.
During childhood, cognitive aspects of the prefrontal cortex are in the maturation phase. This process is associated with improvements in executive functions, in a continuous process, and although differentiated by its multiple aspects, it seems to correspond with the development peaks of the prefrontal cortex, which occur between 7 and 9 years of age. In addition to the biological alterations arising from the growth and development of the brain, physical activity performed regularly indicates a simple and effective way to improve the executive functions of children. Contreras-Osorio and colleagues stated that physical activity performed at moderate and vigorous intensities is positively related to working memory, reaction time, executive attention, cognitive flexibility, and planning in children and adolescents aged 10 to 12 years. Other authors highlight that activities involving cardiorespiratory fitness and motor coordination provide an increase in cognitive performance, with improvements in planning capacity, memory, self-control, and value judgment, among other fundamental components for social interaction and academic performance In a previous study, Visier-Alfonso and colleagues evaluated 186 school-age children aged 9 to 11 years and demonstrated positive effects on cardiorespiratory fitness, with increased physical activity, and positive changes in inhibitory control, working memory, and brain structure. Additionally, good levels of motor coordination are associated with complex movements and sport-specific skills, and are also essential for the development of higher levels of cognitive function. The relationships between motor skills and executive functions during childhood are based on coactivation events between the prefrontal cortex, the cerebellum, and the basal ganglia during different motor and cognitive tasks, especially when the task is complex, is a new task, or requires speed and concentration. This is because neural regions typically associated with cognitive operations can also be recruited during the performance of motor tasks.
The invention relates to a method for extracting phyllanthus, whereby (a) phyllanthus constituents are extracted with an ethanol/water mixture of 5-85 % m/m, to which a heavy metal chelating agent in a concentration of 0.001-3 % m/m is added; (b) the primary extract obtained in step (a) is mixed and concentrated with (ba) indian sterculia gum in a final concentration of 0.5-5.0 % mm, in relation to the sum of the extractive matter, or (bb) at least one polymer and substances which can form a suspension and/or are soluble; and (c) the concentrated extract obtained in step (b) is dried. The inventive method enables particularly high yields of pharmacologically active plant ingredients to be obtained and is thus of particular interest for therapeutic uses. In a preferred form of embodiment, the inventive method comprises a step for filtering the primary extract. It is also preferable to add a lipoid during the extraction method. The phyllanthus is preferably phyllanthus amarus. The invention further relates to pharmaceuticals containing extracts obtained by means of the inventive method.
The beginning of the COVID-19 pandemic was marked by a sharp decline in syphilis infections in many countries worldwide, including Greece. However, a resurgence of positive cases started to appear in the second half of 2020. The aim of this study was to explore the impact of the pandemic on the incidence of new syphilis infections and reinfections and analyze the sociodemographic characteristics associated with recurrent episodes. We analyzed medical records from a 14-month period after the beginning of the pandemic and compared them with the respective period before the start of the pandemic. Our participants consisted mainly of men, with a median age of 43 years, homosexual orientation, and higher education. During COVID-19, more HIV patients presented for syphilis testing (38.0% vs. 34.6%, p = 0.025). Overall, we observed almost a two-fold increase in positive syphilis cases during COVID-19 (21.1% vs. 12.4%, p < 0.001), with new infections rising from 8.4% to 13.2% and reinfections from 4.0% to 7.9%. Multivariable logistic regression analysis revealed that the COVID-19 pandemic, among different parameters (such as age, gender, sexual orientation, HIV status, and educational level), was the only factor associated with higher positive syphilis rates (OR 1.47, 95% CI: 1.07-2.01, p = 0.003). Our results highlight the need to ensure enhanced prevention and undisrupted healthcare services, with a focus on future pandemics.
FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology. A method for manufacturing an inactivated aluminum hydroxide vaccine against pig salmonellosis is proposed, including separate cultivation in a liquid nutrient medium in fermenters of salmonella cultures of vaccine strains Salmonell choleraesuis No. 370, Salmonella typhimurium No. 371, Salmonella abortusovis No. 372 and Salmonella dublin No. 373, followed by inactivation with formaldehyde, adsorption on aluminum hydroxide, decanting clear supernatant with the preparation of a given concentration of microbial bodies in the sediment of each salmonella strain 15.0-25.0×109mb/cm3; then cultures of salmonella strains in the vaccine are mixed in equal volumes.EFFECT: invention provides protection of productive animals from diseases of salmonella etiology.1 cl, 1 tbl, 5 ex
The invention discloses a proved prescription used for treating influenza. Cold is an acute upper respiratory tract inflammation caused by viruses. Cold occurs most frequently when weather changes. Influenza, also called as flu, is characterized by strong epidemicity and acute onset and has the symptoms consisting of fever, chill, headache, nasal obstruction, runny nose, red, swollen and sore throat, nausea and vomiting and severe coughing. The proved prescription adopts Chinese herbal medicines as raw materials for treatment of influenza; a decoction is extracted from the raw materials by using a traditional herbal medicine decocting method and taken orally; the prescription realizes treatment of influenza based on nosogenesis, has no toxic and side effects and exerts a unique treatment effect on fever, chill, headache, nasal obstruction, runny nose, red, swollen and sore throat, nausea and vomiting and coughing. The prescription is developed on the basis of years of repeated research and healing of considerable cases of patients in tens of years; according to clinical observation of curative effects, a total effective rate of the prescription is 96%, and a cure rate of the prescription is 92%. The proved prescription for treating influenza has a strong anti-cold effect, exerts a substantial curative effect on prevention of influenza, can enhance antibiotic, antiviral and immunologic functions of a human body, has the advantages of a short treatment course, fast action, good consolidation performance and convenience in administration and is the only integral therapy prescription for treatment and prevention of influenza.
INTRODUCTION: Rectal bleeding commonly occurs in elderly patients using blood thinners, posing management challenges due to limited guidance on reversal agents and medication restart criteria. This study aims to review the demographics and management of elderly patients with rectal bleeding while on blood thinners.
METHODS: A retrospective analysis of patients aged 60 or older presenting with rectal bleeding at West Suffolk Hospital's emergency department was conducted from January 2018 to December 2020. Data were extracted from electronic records, focusing on patients using blood thinners and adhering to British Society of Gastroenterology guidelines. All patients ceased blood-thinning medications upon admission. The hospital's ethics committee approved the study, which focused on demographics, diagnosis, and management, particularly regarding re-initiation of blood-thinning medicines.
RESULTS: During the study period, 170 patients were admitted to the emergency department of West Suffolk Hospital. 93 (54.71%) patients were included in the study. The average age of the participants was 82 years, and 62.3% were male. All patients were followed up for three months. Atrial fibrillation accounted for 52% of patients, while previous strokes accounted for 20%. The most typical pathology was diverticulosis.Regarding restarting of anticoagulants, Among patients on DOAC (Direct oral anticoagulant), 39% were restarted on discharge, 23% were switched to warfarin, and another 23% were not restarted; 15% planned to restart after seven days. For those on Warfarin, 62% were restarted on discharge, 22% stopped the medication, and the rest were switched to Dual Oral Anticoagulant. Among aspirin patients, 60% were restarted at discharge, while the remaining discontinued. All patients receiving clopidogrel and dual antiplatelet therapy were started at discharge. None of the patients were readmitted during the follow-up period of 3 months.
CONCLUSION: Restarting of blood-thinning drugs in patients with rectal bleeding is subject to individual patient variation. Necessitates more extensive trials to achieve greater standardization.
PEG (Compound polyethylene glycol electrolyte powder) group: 3LPEG. At 18:00 1d before the inspection, dissolve a package of contents into 200ml with water, and drink 250ml of water every half hour after that, drinking a total of 6 cups; On the day of the examination (6 hours before the colonoscopy) repeat the same medication as the previous evening.
OBJECTIVE: Ventilation is the main respiratory support therapy for acute respiratory distress syndrome, which triggers acute lung injury (ALI). Macrophage polarization is vital for the resolution of inflammation and tissue injury. We hypothesized that transforming growth factor (TGF)-β1 may attenuate inflammation and ventilator-induced ALI by promoting M2 macrophage polarization.
METHODS: C57BL/6 mice received 4-hour ventilation and extubation to observe the resolution of lung injury and inflammation. Lung vascular permeability, inflammation, and histological changes in the lungs were evaluated by bronchoalveolar lavage analysis, enzyme linked immunosorbent assay, hematoxylin and eosin staining, as well as transmission electron microscope. TGF-β1 cellular production and macrophage subsets were analyzed by flow cytometry. The relative expressions of targeted proteins and genes were measured by immunofuorescence staining, Western blot, and quantitative polymerase chain reaction.
RESULTS: High tidal volume-induced injury and inflammation were resolved at 3 days of post-ventilation (PV3d) to PV10d, with increased elastic fibers, proteoglycans, and collagen content, as well as higher TGF-β1 levels. M1 macrophages were increased in the acute phase, whereas M2a macrophages began to increase from PV1d to PV3d, as well as increased M2c macrophages from PV3d to PV7d. A single dose of rTGF-β1 attenuated lung injury and inflammation at end of ventilation with polymorphonuclear leukocyte apoptosis, while nTAb pretreatment induced the abnormal elevation of TGF-β1 that aggravated lung injury and inflammation due to the significant inhibition of M1 macrophages polarized to M2a, M2b, and M2c macrophages.
CONCLUSIONS: Precise secretion of TGF-β1-mediated macrophage polarization plays a crucial role in the resolution of ventilator-induced inflammatory lung injury.
Ingested beetroot contains inorganic nitrate (NO3-) which is later converted to nitric oxide (NO) in the bloodstream. NO is an important signaling molecule with several physiological functions in the body including acting as a vasodilator, expanding arteries and improving blood flow. These functions mean that beetroot juice has become of strong interest in the field of exercise and is a recommended supplement for athletes to improve performance in recent consensus statements by the International Olympic Committee on dietary supplements. Importantly, the consumption of beetroot has been shown to improve skeletal muscle contractility and metabolism, hence, enhancing high-intensity exercise performance . Isotonic sports drinks contain carbohydrates and sodium, which also improve exercise performance by providing exogenous glucose for energy to the working muscle and central nervous system and enabling faster absorption of fluid into the bloodstream. The ingestion of exogenous nitrate and isotonic-carbohydrate drink are recognized strategies for promoting exercise performance but whether they can be effectively combined has not been shown. This study will compare the salivary nitrite response, muscle oxygenation and time-trial performance after ingestion of two drinks either high in nitrate or with no nitrate. Participants will ingest the two drinks in a randomised, crossover double-blind trial. One hour after drink ingestion they will undertake high intensity intermittent exercise for 30 minutes followed by a 10 km time trial on a cycle ergometer. Time trial will be compared between trials as the main outcome. It is hypothesised that the drink high in nitrate will lead to faster time trial completion.
ABSTRACT OF THE DISCLOSURE:           A method of preparing a pharmaceutical composition for alleviation of uremic symptoms.  According to the invention, a species of urea, creatine, creatinine or uric acid degrading microorganism is selected and thereafter cultivated in order to determine that only one cell type grows in a culture medium containing thiamine, pyridoxine, Ca-pantothenic acid, nicotinic acid, p-amino benzoic acid, each in an amount of 0.25 mg, 0.05 mg of folic acid, 1 µg of B12 vitamin, 0.5 µg of biotine, 1.0 g of K2HPO4, 1.5 g of NaH2PO4 ? 4H2O, 0.05 g of MnC12 ? 4H2O, 0.1 g of MgSO4 ? 7H2O, 0.01 g of FeSO4 ? 7H2O, 1.0 g of yeast extract and 10 g/1000 ml of urea creatine, creatinine or uric acid as substrate at a pH value of 7.0 to 7.5, the bacterial culture being cultivated at + 28°C in a fermentation vessel, the cell mass is washed repeatedly until the substrate is removed, the washed pure cell mass is added to a 1 molar glucose solution at a ratio of 1:1 as stabilizer, whereafter the product is freezed in liquid nitrogen, thereafter lyophilized 48 to 72 hours at - 50°C and 0.03 torr, the freezedried cell mass is exposed to an inert gas, while being protected from atmospheric oxygen, and the product is mixed with a pharmaceutical carrier and then formed into an orally administra-ble composition. This composition is active in the gastro-intestinal tract of persons suffering from urea; in addition to having a specific non-protein nitrogen compounds degrading effect, it reduces the formation  and concentration of nitrogen containing waste products in the organism.
PROBLEM TO BE SOLVED: To detect an autoantibody found with a high ratio in a patient blood serum by using a reagent for detecting the autoantibody including myosillin or its fragment, bringing a living matter sample into contact with the myocilin or its fragment, and detecting an antibody bonded to the myocilin or its fragment. SOLUTION: Myocilin can be refined by using myocilin manifestation tissues such as retinas, thyroids or the like, or cultured cells of the tissues as a material. Or myocilin can be obtained as a recombinant by isolating a cDNA for encoding myocilin from the tissues and incorporating the cDNA into an appropriate manifestation system. Using the recombinant is preferred because myocilin can be obtained inexpensively by a large quantity. The myocilin for use in detecting an autoantibody is not only one with a complete amino acid sequence, but a fragment including its antigen determinant is utilizable. The autoantibody can be detected by bringing a body fluid sample originated from a patient in to contact with the myosillin or its fragment. The autoantibody bonded to the myocilin can be detected by a known immunoassay.
Neuropathic pain continues to be a significant problem that lacks effective solutions for every single patient. In 2015, international guidelines (NeuPSIG) were published, while the French recommendations were updated in 2020. The purpose of this minireview is to provide an update on the process of developing evidence-based recommendations and explore potential changes to the current recommendations. Primary treatments for neuropathic pain include selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine and venlafaxine, gabapentin, tricyclic antidepressants, as well as topical lidocaine and transcutaneous electrical nerve stimulation, which are specifically suggested for focal peripheral neuropathic pain. Pregabalin is a first line treatment according to international guidelines but second-line in the more recent French guidelines, due to lower efficacy seen in more recent studies and misuse risk. Additionally, tramadol, combination therapies, and psychotherapy as adjuncts are proposed second line; high-concentration capsaicin patches, and botulinum toxin A are proposed specifically for focal peripheral neuropathic pain. In cases where primary and secondary treatments prove insufficient, third-line options come into play. These include high-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the motor cortex, spinal cord stimulation, and the use of strong opioids when no alternative is available. To ensure optimal management of neuropathic pain in real-life situations, it is imperative to disseminate these recommendations widely and secure the acceptance of practitioners. By doing so, we can bridge the gap between theory and practice, and enhance the overall care and treatment of individuals suffering from neuropathic pain.
Awareness training based on the Health Belief Model will be given to the participants in the Intervention 1 group during home visits in order to eliminate the lack of information about the common female cancers in women and to increase their awareness. For 3 months, intervention 1 group will be given applications to reinforce their awareness in the education based on the Health Belief Model (for BSE and KKVM, erasable calendar magnets, booklets, phone cases and accessories themed as "common cancers awareness in women" as a reminder, phone call) will be made.