anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: Patients with acute ST-segment elevation myocardial infarction (STEMI) are at high risk for recurrent coronary events (RCE). Non-culprit plaque progression and stent failure are the main causes of RCEs. We sought to identify the incidence and predictors of RCEs.
METHODS: Eight hundred thirty patients with STEMI were enrolled and followed up for 5 years. All patients underwent blood test analysis at hospital admission, at 1-month and at 12-month follow-up times. Patients were divided into RCE group and control group. RCE group was further categorized into non-culprit plaque progression and stent failure subgroups.
RESULTS: Among 830 patients with STEMI, 63 patients had a RCE (7.6%). At hospital admission, HDL was numerically lower in RCE group, while LDL at both 1-month and 12-month follow-up times were significantly higher in RCE group. Both HDL at hospital admission and LDL at 12-month follow-up were independently associated with RCEs (OR 0.90, 95% CI 0.81-0.99 and OR 1.041, 95% CI 1.01-1.07, respectively). RCEs were due to non-culprit plaque progression in 47.6% of cases, while in 36.5% due to stent failure. The mean time frame between pPCI and RCE was significantly greater for non-culprit plaque progression subgroup as compared to stent failure subgroup (27 ± 18 months and 16 ± 14 months, P  = 0.032).
CONCLUSION: RCEs still affect patients after pPCI. Low levels of HDL at admission and high levels of LDL at 12 months after pPCI significantly predicted RCEs. A RCE results in non-culprit plaque progression presents much later than an event due to stent failure.
Water is passed over substances, soluble or miscible in water before passing through a spary or jet. The physiochemical properties of the water may thus be modified. Suitable substances e.g. carboxymethylcellulose, polysiloxane, PVA, colloidal silica, sodium polyphosphates may be placed in interchangeable or rechargeable containers situated before the spray. May be used in bathroom showers, shampoos and car washes. Substances may be used successively which would be incompatible in a bath.
Children with Cerebral Palsy have weakness in thier muscles due to cortical lesions leading to deficiencies in motor control, balance and functional abilities. All children with Cerebral Palsy have shown to present with foot and ankle disorders; the ankle dorsi and plantar flexor muscles are both problematic; the plantarflexors are usually spastic and the dorsiflexors are usually not active enough and usually these muscle problems lead to problems in the childrens' gait abilities. When rehabilitation programs are examined, the results of exercises addressing these problems do not have precise answers. Functional strengthening exercises have been proven to be effective in patients with spastic cerebral palsy. However, which exercise is the most effective is unknown. Which muscle goup has the most effect on gait, balance and functional activities is still unclear. Therefore, the investigator's aim in planning this study is to examine the effectiveness of three progressive functional exercise programs in children with unilateral and bilateral spastic cerebral palsy.
BACKGROUND: The Latarjet procedure transfers the coracoid process to the anterior glenoid. This prevents recurrent anterior humeral dislocation but alters the origins of the coracobrachialis (CBR) and short head of the biceps (SHB). The impact of this alteration on the moment arms of these muscles has not been examined.
METHODS: The Newcastle Shoulder Model was updated with 15 healthy cadaveric bone models to create customized shoulder models. The CBR and SHB muscles were attached to the anterior glenoid via an elliptical wrapping object. Muscle moment arms were calculated for abduction, forward flexion, scapular plane elevation, and internal rotation with 20° and 90° of abduction. Statistical comparison of moment arms between native and Latarjet shoulders was performed using spm1D.
RESULTS: By transferring the origins of the CBR and SHB to the anterior glenoid, both muscles had extension moment arms during glenohumeral elevation in the coronal, sagittal, and scapular planes. Their average moment arms during abduction (-30.4 ± 3.2 mm for CBR and -29.8 ± 3.0 mm for SHB) and forward flexion (-26.0 ± 3.1 mm for CBR and -26.2 ± 3.2 mm for SHB) suggested that their role after the Latarjet procedure changed compared with their role in the native shoulder (P < .001). At higher abduction levels, both the muscles had higher internal rotation moment arms compared with the native shoulder.
CONCLUSION: The Latarjet procedure affected the moment arms of the CBR and SHB. Both muscles had increased extension and internal rotation moment arms at higher degrees of elevation compared with the native shoulders. This finding suggests that these muscles act as dynamic stabilizers after the Latarjet procedure.
The present invention relates to a method for processing tea tree product, in particularly, a method for processing tea flower. The process comprises of the following steps: picking, dehydrating, steaming, drying, quick-freezing and pulverizing of the tea flowers. The picking step is preferably carried out in the time interval beginning from 2-3 days before the pollination of the tea flower to 2-3 days after the pollination of the tea flower. Hollow baskets made of bamboo or plastics are used to accommodate the picked tea flowers during the picking and the said tea flowers must be immediately graded and spread. In the dehydrating step, the said tea flowers should be spread at a thickness of 2-5 cm on bamboo mat or cement floor and should be gently turned over once every 1 hour. The time of dehydrating for the spread fresh flowers does not exceed 10 hours and the most preferred spreading time is 6 hours. Having been dehydrated, the tea flowers are steamed. A steamer for tea preparation is used directly and the temperature heating the flowers is controlled in a range of 80-100° C.; The drying step is carried out in several times and most preferably in 3-4 times. The temperature of drying is controlled in a range of 60-180° C. The thickness of the flower on the baking plate of the dryer is in the range of 2-3 cm. After every drying, the tea flowers are taken out of the dryer and spread until cool. The time for spreading cool should be getting longer and longer each time. In the quick-freezing step, the tea flowers are quick-frozen at −20° C. to −40° C. for 20 minutes. In the pulverizing step, the quick-frozen flowers are taken out of the freezer and immediately put into pulverizer to be pulverized. The whole production process is conducted in a natural way and no chemical reaction or chemical extraction is involved. Therefore natural nutrients and different kinds of effective ingredients of the tea flowers could be preserved to a maximum degree.
he present invention describes an obesity (OB) polypeptide having about 145 to 167 amino acids, capable of modulating body weight in an animal, or allelic variants or analogs and relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight. The nucleotide sequences in object represent the genes corresponding to the murine and human OB gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial or a mammalian cell transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above-mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the OB polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human OB polypeptides are provided.
This group will receive three 45-minute whole body vibration training sessions for 10 consecutive weeks. The vibration will be of low intensity (frequency: 20 Hertz, amplitude: 1mm).
The Healing Accelerator is a bio-absorbable device that takes internal wound healing to a new dimension. The Healing Accelerator supplies otherwise nutrient-deprived connective tissues of a animals, i.e. ligaments and tendons, with the necessary growth factors to begin the regeneration and growth process that must occur for healing to successfully take place. The Healing Accelerator cannot only be used for the storing and diffusion of growth factors, but it also can be used to deplore drugs in specific regions of the body. The Healing Accelerator shall take various shapes and forms dependent upon the location of the area of concern in the body, i.e. wound. The Healing Accelerator shall be a permeable membrane that allows the diffusion of growth factors such as VEGE or drugs/medicine into the damaged blood vessels and tissue. By deploying these factors into nutrient-starved regions of the body, the healing process is initiated earlier and the time needed for full recovery is thus lessened. This reduction in healing time will in consequence, reduce costs incurred by the insurance companies and the like.
Sepsis is the most common cause of death from infection in the world. Unfortunately, there is no specific treatment for patients with sepsis, and management relies on infection control and support of organ function. A better understanding of the underlying pathophysiology of this syndrome will help to develop innovative therapies. In this regard, it has been widely reported that endothelial cell activation and dysfunction are major contributors to the development of sepsis. This review aims to provide a comprehensive overview of emerging findings highlighting the prominent role of mitochondria in the endothelial response in in vitro experimental models of sepsis. Additionally, we discuss potential mitochondrial targets that have demonstrated protective effects in preclinical investigations against sepsis. These promising findings hold the potential to pave the way for future clinical trials in the field.
Following enrollment, patients will undergo leukapheresis of peripheral blood for further T cell enrichment, activation and genetic modification using a retroviral vector encoding a CD19targeted CAR, the co-stimulatory ligand 4-1BBL and the EGFRt safety system (EGFRt/19-28z/4-1BBL). These T cells will be expanded and after the appropriate number of cells is generated, the modified T cells may be infused fresh or frozen for later use according to standard operation procedures. Modified T cell infusions will be administered 2-7 days following completion of the treating investigator's choice of conditioning chemotherapy. Serial sampling of blood and bone marrow will be performed following treatment to assess toxicity, therapeutic effects, and survival of the genetically modified T cells.
The invention relates to the application of propylene glycol as a prophylactic agent for dairy cow postpartum ketosis. According to the technical scheme of the invention, on the parturition day, the second day and the third day, a dairy cow is successively perfused with 300 ml to 500 ml propylene glycol for three days. In this way, the morbidity of the dairy cow postpartum ketosis is obviously reduced, while the energy negative balance and the liver function of a dairy cow herd are obviously improved. Meanwhile, the reproductive performance of the dairy cow herd is obviously improved through the perfusion process of propylene glycol after delivery, which shows up as the significant reduction in insemination times, breeding days and calving interval. Moreover, the reproductive performance of the dairy cow herd is further improved through the perfusion process of 500 ml propylene glycol. The energy negative balance of the dairy cow herd is effectively relieved through the perfusion process of propylene glycol after delivery, which shows up as the significant increasing in blood glucose and the significant reduction in BHBA and NEFA. In addition, the perfusion effect of 500 ml propylene glycol is better in increasing blood glucose and reducing blood ketone.
Participants in this group will receive a single injection for calot's triangle block combined with PCIA post-operatively. CTB will be conducted by bile duct needle and 1.0% 10 ml ropivacaine will be injection in calot's triangle when before surgical dissection.Participants in this group will also receive PCIA after surgery,the regimens of PCIA are included tramadol 800 mg, flurbiprofenaxetil 100 mg with normal saline added up to a volume of 80 ml in total.
Low income women are at greater risk of both obesity and food insecurity (not having consistent access to nutritious and adequate amounts of food). Most weight loss programs targeted at low income women do not focus on gaining skills and knowledge to reduce food insecurity.

Eligible participants will be randomized into one of two groups. The two groups will follow different weight management programs. One group will follow a standard weight management program. The other group with follow the investigations program, the $ensible Weigh Program. Participation in the study will last about 9 months.
PURPOSE: An Echinochloa utilis extract containing alkaloid-based and flavonoid-based compounds is provided to suppress glycosidase. CONSTITUTION: An Echinochloa utilis extract suppresses glycosidase. The extract is prepared using methanol or ethanol. A composition for preventing and treating diabetes or obesity contains the extract as an active ingredient. A functional food contains the extract as an active ingredient. A solvent fraction of the extract is prepared by adding hexane, ethyl acetate, and butanol to the ethanol extract of Echinochloa utilis in order. The solvent fraction contains a compound of chemical formulas 1-4.
PRCIS: Bleb revision procedures for hypotony maculopathy (HM) following glaucoma filtering surgery show promising outcomes, including notable improvements in visual acuity and IOP.
PURPOSE: This study assesses morphologic characteristics using SD-OCT in patients with HM following glaucoma filtering surgery and evaluates the results of its treatment.
MATERIALS AND METHODS: A retrospective analysis of all HM patients between January 2019 and March 2023. Inclusion criteria consisted of both preoperative and postrevision SD-OCT images of the macula and the presence of HM as observed on OCT images preoperatively. HM was graded according to its appearance in OCT both prerevision and postrevision surgery. Changes in visual acuity and IOP were assessed.
RESULTS: A total of 45 eyes of 45 patients were included. In all, 21 eyes had HM limited to retinal pigment epithelium (RPE), 18 eyes had involvement of RPE and photoreceptor layers, and 6 eyes had additional intraretinal or subretinal edema. After revision surgery with IOP elevation, 64% of eyes had complete HM regression with no HM signs in OCT imaging. Overall, 80% of patients achieved at least 1 grade improvement in HM. Preoperative visual acuity increased from 0.7±0.4 (logMAR) to 0.4±0.4 at 2 weeks postoperatively, over the course of an increase of IOP from 3.5±1.8 to 17.1±10.6 mm Hg at day 1. Eyes with complete HM regression had higher IOP at day 1 compared with those without improvement ( P =0.04). The median time between HM onset and revision was 10.0 days for those with complete regression and 27 days for those without improvement ( P =0.04).
CONCLUSIONS: Bleb revision procedures for HM following glaucoma filtering surgery show promising outcomes, including notable improvements in visual acuity and IOP. The timing of revision surgery appears to influence the outcome. In our study, earlier intervention was associated with better results. Even delayed surgeries can lead to an improvement, although complete morphologic restoration may not be achieved in advanced grades of HM.
The present invention relates to anti-coccidial phytogenic formulations. Specifically, anti-coccidial compositions and use thereof are disclosed. An anti-coccidial composition comprises (a) an effective amount of Artemisia indica extract; and (b) an effective amount of Bidens pilosa extract. The composition may further comprise a pharmaceutically acceptable vehicle, excipient, or carrier, and/or an animal feed. The anti-coccidial compositions may be used in the manufacture of a medicament for killing coccidian oocysts, inhibiting oocyst sporulation, reducing sporozoite invasion, and lessening bloody stools, or for alleviating or treating coccidiosis, in a subject in need thereof. In another aspect, the invention relates to use of an anti-coccidial formulation comprising an effective amount of Artemisia indica extract, and a pharmaceutical acceptable vehicle in the manufacture of a medicament for killing coccidian oocysts and inhibiting coccidian oocyst sporulation, and sporozoite invasion.
The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that have transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an .alpha.4 gene, methods for inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections. Further, the present invention discloses that the HSV-1 mutant lacking the .alpha.4 gene, has a secondary mutation in the gene US3 specifying a protein kinase. Thus a functional US3, a viral gene encoding a protein kinase known to phosphorylate serine/threonine within a specific arginine rich consensus sequence, is required in order to block apoptosis. Also disclosed are methods for inhibition of apoptosis using US3 or an US3 encoding gene, methods for inhibiting US3's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.
PROBLEM TO BE SOLVED: To provide a patch material which exhibits necessary tacky adhesive power for a specified period of time and is easily peelable after lapse of the specified period of time by providing one surface of a base with an acrylic tacky adhesive layer into which magnesium silicates are incorporated. SOLUTION: This patch material is formed by using a plastic film as the base and providing the one surface thereof with the acrylic tacky adhesive layer consisting of an independent polymer or copolymer of an alkyl acrylate monomer. The magnesium silicates are incorporated into this tacky adhesive layer at about 3 to 50 pts.wt. per about 100 pts.wt. tacky adhesive. The magnesium silicates include the magnesium silicates further bonded with metals, such as Li and Na, and water of crystallization, etc. The degradation in the tacky adhesive power does not arise if the amt. of the magnesium silicates to be used is below the range described above. The tacky adhesive power is insufficient if the amt. exceeds the range. The amt. of the use is determined according to the kinds and compsn. of the tacky adhesive and the time when the necessary tacky adhesive power is maintained, etc.
Frailty reflects the heterogeneity in aging and may lead to the development of hypertension and heart disease, but the frailty-cardiovascular relationship and whether physical activity modifies this relationship in males and females are unclear. We tested whether higher frailty was positively associated with hypertension and heart disease in males and females and whether habitual movement mediated this relationship. The relationship between baseline frailty with follow-up hypertension and heart disease was investigated using the Canadian Longitudinal Study on Aging at 3-year follow-up data (males: n = 13,095; females: n = 13,601). Frailty at baseline was determined via a 73-item deficit-based index, activity at follow-up was determined via the Physical Activity Scale for the Elderly, and cardiovascular function was self-reported. Higher baseline frailty level was associated with a greater likelihood of hypertension and heart disease at follow-up, with covariate-adjusted odds ratios of 1.08-1.09 (all, P < 0.001) for a 0.01 increase in frailty index score. Among males and females, sitting time and strenuous physical activity were independently associated with hypertension, with these activity behaviors being partial mediators (except male-sitting time) for the frailty-hypertension relationship (explained 5-10% of relationship). The strength of this relationship was stronger among females. Only light-moderate activity partially mediated the relationship (∼6%) between frailty and heart disease in females, but no activity measure was a mediator for males. Higher frailty levels were associated with a greater incidence of hypertension and heart disease, and strategies that target increases in physical activity and reducing sitting may partially uncouple this relationship with hypertension, particularly among females.NEW & NOTEWORTHY Longitudinally, our study demonstrates that higher baseline frailty levels are associated with an increased risk of hypertension and heart disease in a large sample of Canadian males and females. Movement partially mediated this relationship, particularly among females.
This study will investigate whether preoperative CSVD and CyTOF will help to predict the occurencce of Postoprative Cognitive Dysfunction(POCD) in 1 year after surgery. The investigators perform a prospective cohort study among selective cardiac surgery patients between 50 to 85 years old. All participates have pre-operative head multimodel MRI in Renji Hospital Affiliated to Shanghai Jiaotong University. Incusion and exclusion criteria and relevant data were collected. Patients' age, gender, specific surgical methods, educational background, BMI, tobacco and alcohol history, and systematic medical history were collected before surgery, specific history (heart disease, heart failure, arrhythmia, cornoary artery stent implantation, and history of cardiac surgery), medical history (blood pressure medication, anti-arrhythmic drugs, diuresis, anti-arrhythemic drugs, diuresis, anticoagulant drugs), laboratory examination, auxiliary examination(blood routine, blood coagulation, liver and kidney function, etc.), and Cognitive Function Assessment Scale(MMSE, MOCA, ADL, GDSS). Perioperative indicators were also collected, including use of anesthetics, anestetic time,vital signs, etc. Blood sample should be taken before and after surgery. Postopeative data including: POD whithin 5 days after surgery, cardiovascular drugs use in ICU, mechanical ventilation time, length of stay in ICU, occurrence of complicatiosns of patients, Cognitive function Assessment Scale 1 year after surgery. POD was assessed by a professionally trained clinician twice daily at 8-12 hour intervals, using CAM-ICU scale, if diagnosis with POD, DRS-98 is used to evaluate th severity of POD. POCD was assessed by a professionally trained clinican at 1 year after surgery. The incidence of POD and POCD was analyzed between groups, and the association between each index and delirium and POCD was analyzed by logistic regresssion. The waste blood from routine peripheral blood examination was collected before operation, at the end of operation, on the second day after operation and one year after opertion for the detection of biomarkers by CyTOF, and the composite model of MRI and biomarkers was established.