anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to an antibacterial color sky light peptide, which has the amino acid sequence as follows: trp-Asp-Cys. The invention also discloses a preparation method of the antibacterial zenithal peptide. The antibacterial zenithal can be prepared from marine shrimps by performing enzymolysis with protease, separating, purifying and freeze-drying to obtain antibacterial zenithal; the antibacterial color sky light peptide can also be synthesized by adopting a peptide synthesis method or a synthesis and modification method; the synthetic or modification methods include, but are not limited to: biosynthesis, chemical synthesis, enzyme-catalyzed synthesis, ligation, addition, coupling or derivatization. The invention also discloses an antibacterial application of the zenithal peptide. The natural antibacterial agent eliminates the possible side effects of residue, drug resistance and the like caused by artificially synthesized antibacterial agents and antibiotics, can replace the traditional artificially synthesized antibacterial agents, has high antimicrobial activity, and particularly has stronger inhibition capability on aquatic pathogenic bacteria. It can improve the condition of low utilization rate of aquatic byproducts in China, not only improves the utilization rate of aquatic resources, but also can relieve the concern of consumers on food safety of the antibacterial agent.
Subjects who are assigned to the DCD-control group will receive no TKD training during the study period. Instead, they will participate in jogging exercise daily (one hour per day) for 12 weeks. Participants will be encouraged to jog to school or other places every day, as appropriate. Pedometers will be used to monitor their exercise level and enhance habitual physical activity. The pedometer count (steps per day) will be documented in a log book by the parents. Signed log books will be returned to our research personnel after the intervention period. In addition, children with DCD in this group will receive an adapted TKD training menu and 12 training/demonstration sessions immediately after the follow-up testing is completed.
The costoclavicular approach, more recently described, proposes an insertion of the needle under the lower edge of the clavicle but in a lateral way to the axillary artery which makes it possible to reach the nerves at a place where the 3 main nerve bundles are still joined together. The clustering of nerve structures at the injection site may facilitate the spread of local anesthetics.
INTRODUCTION: Tube thoracostomy (TT) is used to drain the pleural cavity in the setting of both traumatic and nontraumatic pathologies. Literature has shown that inappropriate tube positioning occurs in 30% of patients, including TTs placed within the fissure, which may result in further interventions in these patients. Our goal was to compare the rates of TT placed into a lung fissure in a controlled model using a simple approach to direct the tube more toward the bed than the patient's head at the time of placement to validate further investigations of the clinical applicability of this technique.
METHODS: We performed 650 tube thoracostomies in 3 separate cadaver torsos with tracheal intubation and bag valve mask approximating a 50% pneumothorax. TTs were performed by experienced clinicians using a "more toward the head" direction and a "more toward the bed" direction while varying other factors, including side of the chest, tube size, and location on the chest wall, followed by lung re-expansion to better evaluate each approach in different common clinical scenarios. A power analysis was performed for our primary outcome of tube placement in a lung fissure by direction, not for any additional variables. Multivariate analysis was used to determine whether the "head" or "bed" direction was more likely to result in tube placement in a fissure when controlling for other changes.
RESULTS: A total of 650 TTs were placed in 3 cadavers by 2 experienced performers. The overall rate of tube placement in a fissure was 41% using the "head" direction and 13% using the "bed" direction. On multivariate analysis, the "bed" direction also was shown to have significantly decreased tube placement in a lung fissure when controlling for side, tube size, and location (P  <  0.01; odds ratio 0.22; 95% CI, 0.14 - 0.33).
CONCLUSIONS: Aiming more toward the bed than toward the head during TT placement is associated with a significantly decreased chance of placing the TT within a lung fissure in this highly controlled cadaveric proof-of-concept model. This technique requires no changes to standard TT placement set-up, time, cost, or equipment. We propose that it warrants further investigation as a potential intervention to decrease malpositioned tubes.
Children assigned to this arm will brush/clean teeth with a standard children's toothpaste containing 1500 ppm fluoride twice a day for up to 12 months. They will undergo a dental exam by a trained dentist including caries assessment (at baseline, 1, 3, 6, 9 or 12 months), dental plaque photograph, (at baseline, 1, 3, 6, 9 or 12 months), and swab samples for dental plaque and saliva will be collected at all study visits. A questionnaire will be given to address dentifrice and brushing experience at each study visit. A monthly phone call will be made to assess compliance with the study protocol, and to answer any questions or concerns. Data on compliance and side-effects of toothpastes will be collected at each of the calls.
A substituted chroman compound includes R 1a  and R 1b  as substituents selected from hydrogen and phenyl optionally substituted with 1-3 substituents. R 2a  and R 2b  are hydrogen atoms. R 3a  and R 3b  are C1-C4 alkyls, or represent an oxo group, or are C5-C8 alkylene substituents. R 3a  and R 3b  with their attached carbon atom form a ring. Nitrogen atoms replace two non-adjacent carbon atoms in the main chain to the C5-8 alkylene, which is optionally substituted by a thioxo group. n is the number of the substituents Rz. z is the sequence number of the substituent R z . (R z ) is a substituent on the benzene ring attached to a non-nodal carbon atom selected from hydroxyl, halogen, C2-C6 alkenyl, C1-C4 alkoxy, C1-4 alkanoyloxy, heterocyclic C4-C7 alkyloxy having an oxygen atom in the ring and optionally substituted with 1-3 substituents. The compound is used as a tautomer, enantiomer, diastereomer, mixture of enantiomers and/or mixture of diastereomers.
Orthopedic procedures have become increasingly common in clinical practice. With the increasing elderly population, there have been significant developments in recent years in the field of perioperative pain management and anesthesia strategies for patients scheduled for hip surgery. Patients undergoing hip surgery may experience severe pain both postoperatively and during the positioning of the patient during surgery. This leads to increased sympathetic activation such as tachycardia and hypertension in patients, especially in the elderly population, and some undesirable complications due to the patients' existing comorbidities. Therefore, pain management strategies for patients undergoing hip surgery are based on a range of anesthesia techniques, including the use of opioids, neuraxial anesthesia (spinal, epidural, or a combination of them), nerve blocks, especially pericapsular nerve block (PENG), fascia iliaca compartment block (FICB) and femoral block). Reducing patients' pain and improving the quality of postoperative recovery has become increasingly important. The Quality of Recovery-15 (QoR-15) is a 15-question questionnaire validated to assess postoperative recovery. This questionnaire assesses patients' pain, physical comfort, physical independence, psychological support, and emotional status in the early postoperative period. The aim of this study was to evaluate the effect of ultrasound-guided PENG block, FICB block, and femoral block on the quality of recovery as part of multimodal analgesia before hip surgery under spinal anesthesia.
The invention discloses an intelligent blood sampling management system. The system comprises an intelligent hemostix, a mobile device application, a server and a database. The intelligent blood sampling instrument acquires a blood sample by adopting a needleless technology, so as to realize automatic blood sampling management; the mobile equipment application realizes remote monitoring; the server receives and analyzes the blood sampling data; the database stores blood sampling data. The system improves the blood sampling safety and the informationized management level. The intelligent blood sampling instrument automatically calibrates and disinfects, so as to ensure the blood sampling quality; the mobile application displays blood sampling data analysis, so that monitoring is facilitated; the server adopts a cloud computing technology to ensure the processing speed; the database adopts a block chain technology, so that the data security is ensured. In general, the system realizes noninvasive, accurate and efficient intelligent blood sampling management.
Patients will be treated with a single PRP injection, where 8 mL of whole blood will be collected and 2.5 mL of PRP will be given to the patient. Routine physiotherapy regimens will be implemented, similar to placebo arm.
STUDY DESIGN: A cross-sectional and observational study.
OBJECTIVE: To investigate the incidence of bidirectional lumbar facet tropism and its relationship with lumbar spine disease in adolescents.
SUMMARY OF BACKGROUND DATA: There is limited information on facet joint asymmetry in the sagittal plane in adolescents.
MATERIALS AND METHODS: The orientation of all lumbar facet joints was measured in the bidirectional planes on computed tomographic images for 191 patients with low back pain. The patients were divided into 4 groups according to age (<15 or ≥15 yr) and sex. The facet joint angle and tropism rate were compared among the groups. Facet tropism was defined as a difference in bilateral angle of >10° in the axial plane and >5° in the sagittal plane. Facet joint orientation was compared among groups using a one-way analysis of variance and Tukey honestly significant difference test or Games-Howell post hoc test and the incidence of facet tropism using the Kruskal-Wallis test with Bonferroni correction. The association of facet tropism with disease was investigated further by analyzing facet joint orientation and the incidence of facet tropism in 116 patients with single-level lumbar disease.
RESULTS: Facet tropism was observed in 8.7% of axial views and 7.5% of sagittal views. The incidence of axial facet tropism was significantly higher in male patients aged ≥15 years, especially at L4/5. Facet joint morphology in the axial plane was more coronal at L3/4 and L4/5 in male patients ≥15 years than in those <15 years. Facet joint morphology in the sagittal plane was unchanged at around 15 years of age in both sexes. Axial facet tropism was found at L4/5 in 55.6% of patients with herniated nucleus pulposus. There was a significant difference in sagittal facet orientation in patients with spondylolysis at L5. The facet angle was significantly larger in patients with L5 spondylolysis at L3/4 and L4/5.
CONCLUSIONS: Facet tropism in adolescents is similar in the axial and sagittal planes. Facet tropism and specific morphology may be related to lumbar disk herniation and spondylolysis in this age group.
An apparatus comprises a communication channel comprising a plurality of disparate sequential communication links configured to facilitate bi-direction communication between an implantable medical device (IMD) and a programmer. A transceiver is configured to communicate with the programmer via a first communication link of the plurality of disparate communication links. A telemetry device is configured to communicate with the IMD via a second communication link of the plurality of disparate communication links. A third communication link communicatively couples the transceiver and the telemetry device. A power source is coupled to the transceiver and to the telemetry apparatus. An operational status of at least the first and second communication links can be individually determined in real-time.
Healthcare transaction validation systems and methods are presented. Healthcare transactions associated with a stakeholder are compiled into a chain of healthcare transaction blocks. The chain can be considered a chronicle of person's healthcare path through life. When a transaction is conducted, the corresponding healthcare parameters (e.g., inputs, outputs, clinical evidence, outcomes, etc.) are sent to one or more validation devices. The devices establish a validity of the transaction and generate a new block via a proof-of-work principle. Once the new block has been calculated it can be appended to the stakeholder's health care blockchain.
A veterinary preparation for the treatment of mastitis comprises one or more of the following antibiotics: novobiocin and salts thereof, dihydronovobiocin and salts thereof and chloramphenicol, in a medium consisting of a mineral oil gelled with a parenterally acceptable metal soap.  Specified salts of novobiocin and dihydronovobiocin are the potassium and sodium salts.  The metal soaps are commercial aluminium or lithium stearate or soaps of these metals with long chain aliphatic acids containing 10 to 28 carbon atoms and mixtures thereof.  Aluminium stearate is used in a concentration of 1 to 8% and preferably 3% of the final product and lithium stearate in a concentration of 0.1 to 10% and preferably 0.6 to 1%.  The term mineral oil covers mixtures of hydrocarbons known as liquid and light liquid paraffin and mixtures of the same with white or yellow soft paraffins or petroleum jellies.  The amount of antibiotic used in the preparation is 3.5 to 18% and preferably 8.6% for novobiocin, dihydronovobiocin or their salts, 5 to 15% and preferably 10% for chloramphenicol.  Additional antibiotics may be included e.g. penicillin, streptomycin and dihydrostreptomycin or their salts such as procaine penicillin G and streptomycin or dihydrostreptomycin sulphate and in particular chlorotetracycline, oxytetracycline or tetracycline in a concentration of 2.5-10%. Specifications 665,367, 678,823 and 792,559 also are referred to.
Methods are provided for producing a population of substantially purified CD4+ Thl lympbocytes. The method includes stimulating a population of substantially purified CD4+ T cells isolated from a subject by contacting the population with an anti-CD3 monoclonal antibody and an antibody that specifically binds to a T cell costimulatory molecule in the presence of a Th1 supportive environment to form a stimulated population ofT cells. The stimulated population of CD4+ T cells is allowed to proliferate in a Th1 supportive environment. In one example, the Thl supportive environment includes at least 20 IU/ml ofIL-2, for example about 1000 I.U./ml ofIL-2, and a neutralizing amount of an IL-4, an IL-13, and/or an IL-4/IL-13 neutralizing agent. In other examples, the supportive environment further includes at least I ng/ml ofIL-12, for example about 2.5 ng/ml of IL-12. Purified populations ofTh1 cells are disclosed herein, as are methods for their use.
Intracerebral hemorrhage (ICH) is a fatal brain injury, but the current treatments for it are inadequate to reduce the severity of secondary brain injury. Our study aims to explore the molecular mechanism of Egr1 and Phlda1 in regulating hemin-induced neuronal pyroptosis, and hope to provide novel therapeutic targets for ICH treatment. Mouse hippocampal neuron cells treated with hemin were used to simulate an in-vitro ICH model. Using qRT-PCR and western blot to evaluate mRNA and protein concentrations. MTT assay was utilized to assess cell viability. LDH levels were determined by lactate Dehydrogenase Activity Assay Kit. IL-1β and IL-18 levels were examined by ELISA. The interaction of Egr1 and Phlda1 promoter was evaluated using chromatin immunoprecipitation and dual-luciferase reporter assays. Egr1 and Phlda1 were both upregulated in HT22 cells following hemin treatment. Hemin treatment caused a significant reduction in HT22 cell viability, an increase in Nlrc4 and HT22 cell pyroptosis, and heightened inflammation. However, knocking down Egr1 neutralized hemin-induced effects on HT22 cells. Egr1 bound to the promoter of Phlda1 and transcriptionally activated Phlda1. Silencing Phlda1 significantly reduced Nlrc4-dependent neuronal pyroptosis. Conversely, overexpressing Phlda1 mitigated the inhibitory effects of Egr1 knockdown on Nlrc4 and neuronal pyroptosis during ICH. Egr1 enhanced neuronal pyroptosis mediated by Nlrc4 under ICH via transcriptionally activating Phlda1.
When used for contrast enhancement in computed tomographic brain scanning, the degree of enhancement is directly related to the amount of iodine administered. Rapid injection of the entire dose yields peak blood iodine concentrations immediately following the injection, which fall rapidly over the next five to ten minutes. This can be accounted for by the dilution in the vascular and extracellular fluid compartments which causes an initial sharp fall in plasma concentration. Equilibration with the extracellular compartments is reached by about ten minutes; thereafter, the fall becomes exponential. Maximum contrast enhancement frequently occurs after peak blood iodine levels are reached. The delay in maximum contrast enhancement can range from five to forty minutes, depending on the peak iodine levels achieved and the cell type of the lesion. This lag suggests that the contrast enhancement of the image is at least in part dependent on the accumulation of iodine within the lesion and outside the blood pool. 

In brain scanning, the contrast medium (Conray) does not accumulate in normal brain tissue due to the presence of the “blood brain barrier.” The increase in x-ray absorption in the normal brain is due to the presence of the contrast agent within the blood pool. A break in the blood brain barrier, such as occurs in malignant tumors of the brain, allows accumulation of contrast medium within the interstitial tumor tissue; adjacent normal brain tissue does not contain the contrast medium. 

The image enhancement of non-tumoral lesions, such as arteriovenous malformations and aneurysms, is dependent on the iodine content of the circulating blood pool. 

When used for cranial computerized angiotomography, rapid bolus injection and/or infusion combined with rapid CT scanning will provide clear delineation of the cerebral vessels.
Brain-computer interface (BCI) offers a novel means of communication and control for individuals with disabilities and can also enhance the interactions between humans and machines for the broader population. This paper explores the brain neural signatures of unmanned aerial vehicle (UAV) operators in emergencies and develops an operator's electroencephalography (EEG) signals-based detection method for UAV emergencies. We found regularity characteristics similar to classic event-related potential (ERP) components like visual mismatch negativity (vMMN) and contingent negative variation (CNV). Source analysis revealed a sequential activation of the occipital, temporal, and frontal lobes following the onset of emergencies, corresponding to the processing of attention, emotion, and motor intention triggered by visual stimuli. Furthermore, an online detection system was implemented and tested. Experimental results showed that the system achieved an average accuracy of over 88% in detecting emergencies with a detection latency of 431.95 ms from the emergency onset. This work lays a foundation for understanding the brain activities of operators in emergencies and developing an EEG-based detection method for emergencies to assist UAV operations.
Modeling Amyotrophic Lateral Sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation, and aging of spinal motor neurons (spMNs) in vitro. As the maturity of spMNs grown in vitro compared to spMNs in vivo remains largely unaddressed, it is unclear to what extent this in vitro system captures critical aspects of spMN development and molecular signatures associated with ALS. Here, the Inventors compared transcriptomes among iPSC-derived spMNs, fetal, and adult spinal tissues. The Inventors resolved gene networks and pathways associated with spMN maturation and aging. These networks enriched for familial ALS genetic variants and were affected in sporadic ALS. Altogether, the Inventors' findings suggest that developing strategies to further mature and age iPSC-derived spMNs will provide more effective iPSC models of ALS.
ZYLOPRIM (allopurinol) is a xanthine oxidase inhibitor. It has the following structural formula:

ZYLOPRIM is known chemically as 1, 5-dihydro-4H-pyrazolo [3, 4-d]pyrimidin-4-one and it has a molecular weight of 136.11 g/mol. Its solubility in water at 37°C is 80.0 mg/dL and is greater in an alkaline solution. It is a xanthine oxidase inhibitor which is administered orally.  
Each scored white hexagon-shaped tablet contains 100 mg allopurinol and the inactive ingredients lactose monohydrate, magnesium stearate, potato starch, and povidone.  
Each scored white round tablet contains 200 mg allopurinol and the inactive ingredients lactose monohydrate, magnesium stearate, corn starch, and povidone.  
Each scored peach tablet contains 300 mg allopurinol and the inactive ingredients corn starch, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, and povidone.
PURPOSE: The main purpose of this study is to compare the validity of transcervical embryoscopy method with standard uterine evacuation method in detecting more accurate karyotypes in miscarriages below tenth week of pregnancy. Additionally, the frequency and distribution of fetal morphological abnormality were evaluated.
METHODS: A prospective study was carried out at the Gazi University Faculty of Medicine, Department of Obstetrics and Gynecology. Patients with missed abortions between sixth and tenth gestational weeks were included in the study group, and fetal morphological examination and direct embryonic biopsy were performed by transcervical embryoscopy. The control group consisted of patients who experienced miscarriage and genetic material obtained from routine uterine evacuation between February and October 2023.
RESULT: A total of 60 patients in the study group and 189 patients in the control group were evaluated. The median ages, previous miscarriage numbers, median gravida numbers, and median gestational weeks were comparable between groups. Chromosomal abnormality was detected in 24 (42.8%) and 52 embryos (29.9%) in the study and control groups, respectively (p = 0.004). Culture failure rates were 6.6% (n = 4) and 7.9% (n = 15) in the study and control groups, respectively. In the study group, 12 embryos had a morphological abnormality in which 6 of them had normal karyotype.
CONCLUSION: Direct embryonic biopsy with transcervical embryoscopy is an effective method to exclude maternal decidual cell contamination and placental mosaicism in miscarriages for karyotype analysis. In addition, detecting anomalies in morphology might contribute our understanding in the process of miscarriages which arises independent from structural/numerical chromosomal abnormalities.