anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The investigators will study the variation in the impact of coffee on metabolic rate and investigate the impacts of age, sex, body composition and regularity of habitual coffee consumption on this effect. The investigators will recruit healthy participants, half male and half female. Participants will be required to perform no strenuous exercise for 14 hours and no moderate of vigorous exercise for 2 hours before the measurements. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. Participants will be randomly allocated into 3 groups and given 180mls of coffee to consume containing 100, 200 or 300 mg of caffeine. A fourth group will be dosed with 100 mg of caffeine containing 13C uniform labelled caffeine to trace the pattern of caffeine degradation via the appearance of 13CO2 in the breath and labelled compounds in the urine. The primary outcome is the change in resting metabolic rate from before and after coffee drinking. Secondary outcome measures are heart rate, electrocardiogram, blood pressure, body temperature which will be measured before and after the coffee consumption. Professional nurses will take 8ml of venous blood from all participants as genotyping blood samples. Genomic DNA will be extracted from whole blood samples and analysed for single nucleotide polymorphisms (SNPS).
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to oncology, and can be used for treatment of cancer of rectum. For this purpose during operation in presacral space till its complete filling-in introduced is medication - "hydrogel napkins with 5-fluoruracyl and sodium alginate "Coletex -5-ftur" with addition of 50 mg of carboplatin. Two drainages of different diameter are installed into presacral space. After that, peritonisation with uninterrupted suture is carried out tightly. On 5-6 day after operation hydrogel "Coletex-gel-DNA" is introduced through drainages into presacral space until it is completely filled. ^ EFFECT: method ensures reduction of frequency of local recurrences and metastases after cancer of rectum surgery due to efficient intraoperative local chemical therapy in combination with reparative therapy after operation. ^ 1 ex
The invention discloses a traditional Chinese medicine composition capable of improving ovarian function injury caused by chemotherapeutics, and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 3-30 parts of mulberry, 4-40 parts of kudzuvine root, 5-50 parts of poria cocos, and 5-50 parts of medlar. A method of preparing a traditional Chinese medicine composition comprising: weighing radix Puerariae and Mori fructus, decocting in water, collecting decoction, filtering decoction, and precipitating with ethanol to obtain extract 1; weighing Poria and fructus Lycii, decocting in water, collecting decoction, filtering decoction, and precipitating with ethanol to obtain extract No. 2; mixing the 1# extract and the 2# extract to obtain the traditional Chinese medicine composition. The application of the traditional Chinese medicine composition in improving ovarian endocrine dysfunction and ovarian fertility dysfunction caused by chemotherapeutics. According to the traditional Chinese medicine composition provided by the invention, according to the guiding thought of the edible homology of traditional Chinese medicine in traditional medicine, the traditional Chinese medicine is reasonably matched with four qi and five flavors, and the traditional Chinese medicine is lifted, floated and assisted and guides. Has effects in relieving ovarian function injury caused by chemotherapy.
It is well established that mindfulness meditation interventions improve a wide-range of mental and physical health outcomes in stressed patient populations, although the underlying mechanisms are currently unknown. It has been suggested that mindfulness training may reduce reactivity to stimuli and improve regulation, although these mechanisms have not been examined (using functional neuroimaging). Additionally, it is well-established that loneliness and inflammation are major risk factors for morbidity and mortality in older adults, although it is currently unknown whether mindfulness meditation training may reduce these risk factors. The purpose of the proposed study is to test if mindfulness meditation training (vs a wait-list control condition) reduces neurobehavioral reactivity and improves affect regulation in a sample of healthy older adults, as measured by functional magnetic resonance imaging. Additionally, we will examine whether mindfulness meditation training reduces loneliness and markers of inflammation.

Participants will be recruited in the Los Angeles area and randomly assigned to the 8-week Mindfulness-Based Stress Reduction (MBSR) intervention or to a wait-list. All participants will provide a blood sample and complete a psychosocial survey before and after the intervention, and complete a 60-minute neuroimaging assessment before and after the MBSR program. All participants who are randomly assigned to the wait-list will be offered the MBSR intervention after the 8-week intervention period and then complete an additional post-test assessment after completing the MBSR program (which will include a blood sample, psychosocial survey, and a neuroimaging assessment). Participants will complete neuroimaging tasks (where they will be presented with words, pictures, and sounds) before and after receiving the MBSR intervention, which will assess neural activity and regulation responses before and after mindfulness meditation training.
A phantom for simulating fetal heartbeat. The phantom includes a housing and a fetal heartbeat simulator. The housing has an exterior shaped like a female human pelvic region and surrounds an interior. The fetal heartbeat simulator includes a tube having a proximal end and a distal end, the distal end being positioned within the interior of the housing. The tube is filled with a first fluid having a first compressibility. A second fluid, having a compressibility that is greater than the compressibility of the first fluid, is disposed at the distal end of the tube. A pressure mechanism operably coupled to the proximal end of the tube is configured to selectively compress and decompress the first and second fluids.
LUNSUMIO can cause serious or fatal infections [see Adverse Reactions (6.1)].

Among patients who received LUNSUMIO at the recommended dose in the clinical trial, serious infections, including opportunistic infections, occurred in 17%, with Grade 3 or 4 infections in 14%, and fatal infections in 0.9% of patients. The most common Grade 3 or greater infections were pneumonia, sepsis, and upper respiratory tract infection.

Monitor patients for signs and symptoms of infection prior to and during treatment with LUNSUMIO and treat appropriately. LUNSUMIO should not be administered in the presence of active infection. Caution should be exercised when considering the use of LUNSUMIO in patients with a history of recurring or chronic infections (e.g., chronic, active Epstein-Barr Virus), with underlying conditions that may predispose to infections or who have had significant prior immunosuppressive treatment. Administer prophylactic antimicrobials according to guidelines.

Withhold LUNSUMIO or consider permanent discontinuation of LUNSUMIO based on severity [see Dosage and Administration (2.4)].
OBJECTIVES: This study used National Health Insurance claims data from Korea to report the prevalence of sleep disorders and treatment status, including traditional Korean medicine, in the last 10 years.
METHODS: This is a retrospective cohort study in Korea. All diagnosis and prescription data, including herbal medicine claims, from the Health Insurance Review and Assessment Service from 2011 to 2020 were reviewed. Prevalence estimation, direct medical expenses and prescribed amounts for sleep disorders were recorded.
RESULTS: The prevalence of sleep disorders increased from 3 867 975 (7.62%) in 2011 to 7 446 846 (14.41%) in 2020, nearly doubling over 10 years. Insomnia was observed in 91.44% (n=9 011 692) of the patients. The mean number of hospital visits per patient for sleep disorders was 11.5 (±26.62). Benzodiazepines are the most commonly prescribed medications for sleep disorders, and gamma-isoyosan is the most frequently prescribed herbal medicine.
CONCLUSIONS: Sleep disorders are continuously increasing, as is the use of medical services-personal and social medical expenses are also increasing accordingly. Sleep disorders should be recognised as a significant health problem that needs to be actively addressed to improve quality of life.
High-density lipoprotein (HDL), known as good cholesterol, is named because of its protective effects on the cardiovascular system. in order to summarize the mechanism of the event, cholesterol is transported from the liver to the cells and from the cells back to the liver via blood. Cholesterol and other fats are carried in packets called lipoprotein to dissolve in the blood. Those with these are two kinds of cholesterol, these low-density lipoproteins and good cholesterol can help to lower the cholesterol as well. LDL cholesterol is the main package that carries cholesterol in the blood. When the blood is high, it sticks to the inside of the veins and forms plaques around here. With the addition of cholesterol, a blood clot that formed in cracks that occur on these plaques grow the arteries and clogs them. If the blockage occurs in the heart vessels, it can cause a heart attack and stroke. Cholesterol in the blood is a part of a package called HDL-cholesterol is carried in. HDL-cholesterol prevents the accumulation of cholesterol in the veins.

It collects the cholesterol circulating in the blood and brings it to the liver to get rid of it from the body. Thus, it reduces the exposure of blood vessels to the harmful effects of cholesterol. All these effects of HDL cholesterol in the paraoxonase enzyme owes. This may be the reason why Dolat may even use another nomenclature instead of HDL in future years. A paraoxonase-1 enzyme, which is known to decrease blood level with age, is found to be significantly lower in patients with myocardial infarction at a young age compared with the healthy control group in this study, and the measurement of this enzyme level can be used as a screening test in people with risk factors.
The present invention relates to a microorganism of which the extract of the fermenting product has the medicinal function, particularly to a fungi grifola frondosa GF-932 [Grifola frondosa (Dichs. ex Fr.) S. F. Gray] which is used as the food or the medicine. The culture method of the microorganism and the production of the microorganism, the grifola frondosa amylose and particular the grifola frondosa beta-1, 3-glucan comprises the application of the grifola frondosa amylose on the production aspect of capsules, hydro-acupuncture, lyophilized powder, etc. for tablets, soft capsules, hard capsules, etc. The grifola frondosa strain is preserved by the common microorganism center of the CCCCM, and the preservation number is CGMCC No. 1709. The grifola frondosa strain of the present invention is obtained from the natural sporophore in wild environment by separation, selection and domestication for a long time, has stable genetic character, and can produce the amylose of the grifola frondosa beta-glucan, etc. in an artificial fermentation way; the present invention has the advantages of fast growth, short period, and high yield for the mycelium and the amylose, and is suitable for large-scale liquid deep culture.
One aspect of the invention relates to a water-dispersible granulate having a mass weighted average diameter of at least 100 m, said granulate comprising: 40-90 wt. % of carbohydrates; 2-30 wt. % of lipids containing at least 1% unsaturated fatty acids by weight of the granulate and at least 30 mg/kg of a pro-oxidative metal selected from the group consisting of iron, copper and combinations thereof; wherein at least 50 wt. % of the lipids is present as non-dispersed lipids. Despite the fact that the present granulate contains a substantial amount of unsaturated fatty acids as well as a high level of iron and/or copper, said granulate is nonetheless very stable against oxidation. The granulate of the present invention is easy to manufacture by a process that does not employ emulsification or pro-oxidative conditions. The present invention also provides a process for the manufacture of the aforementioned granulate.
Pantoprazole sodium in 0.9% sodium chloride injection is supplied as a frozen, premixed, iso-osmotic, sterile, nonpyrogenic single-dose solution packaged in GALAXY container. The single-dose GALAXY plastic containers are available as follows:

Storage and Handling 

Store frozen at or below -20°C /-4°F. Protect from light when stored frozen.

Handle frozen product containers with care. Product containers may be fragile in the frozen state. Storage conditions for the thawed solution are described in another section of the prescribing information. [see Dosage and Administration (2.3)].
Dyspnea is the most common and activity-limiting symptom for those with chronic obstructive pulmonary disease (COPD). Treatment is complex, palliative care (PC) dyspnea relief interventions are poorly understood, and PC remains underutilized in COPD despite national guidelines and recommendations. The purpose of this rapid review was to explore the concept of dyspnea and role of PC through the lens of providers, caregivers, and patients with COPD. A systematic approach for synthesis was used to identify 13 articles published between January 2018 and October 2023. Team members compared data via visualization and theme clustering to identify key conclusions describing operationalization of dyspnea, management, and PC implications. Dyspnea operationalization was challenging, with inconsistent measurement and terminology. Dyspnea was a significant burden in COPD and contributed to complexity of treatment. Opioids were used most often to treat dyspnea, but provider perspectives and biases can influence treatment decisions and perceptions of opioid therapy by the patient and caregiver. Evidence-based clinical practice guidelines and policies are needed to clarify the use of opioid therapy for dyspnea management to reduce stigmatization and barriers to treatment. Provider education should emphasize a multipronged approach to treatment of dyspnea in COPD with integration of PC early in the care continuum.
Multiple sclerosis (MS) is a chronic autoimmune disease with an unknown etiology. The purpose of this research was to assess miR-223, miR-146a, and miR-193a in acute and chronic phases of experimental autoimmune encephalomyelitis (EAE) mice to consider the possible role of these genes in the pathogenesis of MS. EAE induction was given by myelin oligodendrocyte glycoprotein peptide on female C57BL/6 mice. Clinical scores and other criteria were followed daily until day 21 for the acute group and day 77 for the chronic group. At the end of the course, inflammation and demyelination of the central nervous system (CNS) were assessed by histological analysis. MicroRNA expression levels were assessed by real-time PCR. EAE development attenuated in the chronic group, and histological analysis showed less infiltration and demyelination in the chronic group compared to the acute group. The upper expression of miR-223 is demonstrated in the acute phase of EAE. Moreover, the expression levels of miR-146a and miR-193a decreased in the chronic phase of EAE. MiR-223 showed a highly coordinated elevation in the acute phase both in vivo and in vitro. MiR-146a shares a pathway with miR-223 through effecting IL-6 expression. Further studies are needed to reveal their impact on EAE and possible applications as drug targets and biomarkers.
An interactive system for exchanging information about an individual's sexual health status and method for confirming sexual health status of individuals. Basically the system involves means for registering and storing an individual's sexual health status along with his/her personal identity and means for online access to an individual's sexual health status based on said individual's personal identity to ascertain whether the particular individual is STD free or not. Also disclosed is a method for confirming the sexual health status of an individual involving the steps of (a) inputting and recording after proper registration procedures the (b) personal identification; and (c) on-line access to interested persons to the information recorded on an individual's sexual health status on proper submission of personal identification. The system and method would provide for safe guarding the interest of persons free of such diseases to continue to live a safe and healthy life. People can be made more conscious about the needs and purposes of checking of sexual health status without the complexity of delay and time involved in carrying out instant tests. The society at large can benefit by way of having a non-public yet confirmatory source for confirming individual's sexual status.
Patients are first titrated to an optimal dose of stimulant medication. They then undergo the 12 weeks of group cognitive behavioral therapy.
Get Social participants will receive a weight loss intervention in a "protected" Twitter group. The intervention content will be structured to deliver in an online context. The online coaches will post daily content, respond to questions, address concerns, and encourage engagement. The weight loss intervention is based on the Diabetes Prevention Program (DPP), an evidence-based weight loss program focused on lifestyle changes. The goals for the intervention are 175 minutes of moderate physical activity per week and an overall weight loss of 7%. Each participant will get an individualized calorie goal that would facilitate a 1-2 lbs. weight loss weekly. Participants will also be encouraged to use an app such as MyFitnessPal to track daily diet.
Patients will receive continuous oral treatment with 800 mg of sorafenib daily (Nexavar, Bayer HealthCare Pharmaceuticals-Onyx Pharmaceuticals). Treatment interruptions and dose reductions (to 400 mg once daily) will be permitted for drug-related adverse effects. At the discretion of the investigator, the dose may be re-escalated to after the resolution of the adverse event.
Endometriosis is a disease marked by more than just pain and infertility, as it transcends the well-characterized physical symptoms to be frequently associated with mental health issues. This review focuses on the associations between endometriosis and anxiety, depression, sexual dysfunction, and eating disorders, all of which show a higher prevalence in women with the disease. Studies show that pain, especially the chronic pelvic pain of endometriosis, likely serves as a mediating factor. Recent studies evaluating genetic predispositions for endometriosis and mental health disorders suggest a shared genetic predisposition. Healthcare providers who treat women with endometriosis should be aware of these associations to best treat their patients. A holistic approach to care by gynecologists as well as mental health professionals should emphasize prompt diagnosis, targeted medical interventions, and psychological support, while also recognizing the role of supportive relationships in improving the patient's quality of life.
In a medical workspaces management method, a user identified in a users database ( 52 ) is authenticated. At a server computer ( 10 ), a virtual session is created including running instances ( 16 ) of a plurality of medical applications on the server computer with the instances associated with the authenticated user. Using at least one locating service ( 20 ), a current medical content presentation device ( 30, 32 ) is identified which is proximate to the authenticated user. At the server computer, a set of rules is applied to determine content of the instances to be presented. This content is pushed from the server computer to the current medical content presentation device. At the current medical content presentation device, the pushed content is presented on a display ( 40, 42 ) of the current medical content presentation device.
In the BNI plus standard booster arm, patients will receive the 5-30 minute brief negotiational intervention about their alcohol use as well as the standard discharge information and instructions. Then after discharge patients will receive a test focused on reducing alcohol use to a SMS capable cell phone weekly for a total of 6 months of follow up. The messages will be standard messages for all those in this arm.
This disclosure relates a composition for application to disordered tissue caused by a virus, bacteria, fungus or non-pathogenic toxin comprising at least one anti-infective agent comprising an organohalide, a liquid carrier comprising a tissue penetrating component and a topical anaesthetic. The organohalide may be an organochloride and more specifically may be a benzalkonium chloride. The anaesthetic may be benzocaine. The treatment composition is designed to penetrate more quickly into disordered tissue and have an increased residence time in the treatment area. The treatment compositions and methods may employ the use of an applicator. The disclosure also relates to the use of this composition for treatment of disorders caused by a virus, bacteria, fungus or non-pathogenic toxin.
Patients undergoing cardiac surgery are at risk of post-cardiotomy myocardial dysfunction. This condition causes delayed recovery, organ failure, prolonged intensive care unit and hospital stays, and an increased risk of mortality. These patients often require inotropic support, which has been associated with an increased risk of cardiovascular complications. Treatment of myocardial dysfunction includes optimization of myocardial contractility through appropriate fluid and pharmacologic management and mechanical support . Extensive use of inotropes in this situation is needed, but the optimal pharmacologic management of myocardial dysfunction in cardiac surgery is a matter of ongoing debate .Available inotropes including adrenaline may increase myocardial oxygen consumption, heart rate and risk of arrhythmia. An increase in myocardial oxygen consumption by inotropes in a state of inadequate oxygen delivery may further deteriorate underlying cardiac dysfunction and even lead to increased mortality . There are questions regarding the ideal inotrope to use during the post cardiopulmonary bypass (CPB) period in patients undergoing on-pump CABG surgery. The occurrence of myocardial dysfunction after cardiac surgery is a potential indication for the use of levosimendan, a calcium sensitizer with a unique mechanism of action. By binding to cardiac troponin C, it enhances myofilament responsiveness to calcium, thereby increasing myocardial contraction without increasing myocardial oxygen consumption. In addition, levosimendan activates adenosine triphosphate-dependent potassium channels, which are important mediators of ischemic and anesthetic cardioprotection. Levosimendan might thus have a potential benefit for patients with myocardial oxygen imbalance requiring inotropic drug support . The hypothesis of the present study is that levosimendan without loading dose can improve myocardial function and provide better hemodynamics as well as echocardiographic parameters compared with adrenaline in patients with low ejection fraction undergoing op-pump CABG