anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The sociomedical report is an essential basis for making decisions about benefits from social insurance providers. As an instrument of medical information, the sociomedical assessment can be based on very different questions, such as the question of ability to work, earning capacity, participation in professional or social life, or the need for medical treatment. It is important to obtain a comprehensive picture of the individual situation in order to create the basis for decisions about benefit entitlements and support measures. The various issues in the respective sociolegal context may require not only the sociomedical report but also other expertise. The international classification of functioning, disability, and health (ICF) and the World Health Organization (WHO) bio-psycho-social model on which it is based enable health problems and their effects to be considered in the context of life and work. The components of functional ability and disability are assessed in their interaction from a sociomedical perspective. What is important is not the diagnosis but rather the person and the individual impact of the health disorders on their activities and participation.In the case of fatigue and burnout, a medical symptom complex with (psychophysical) exhaustion and the resulting attention and concentration disorders are in the focus of the sociomedical assessment. It can be difficult to objectify symptoms and complaints in these diseases, which can lead to particular challenges during assessment, especially when validating complaints.
PURPOSE:To provide the titled agent useful for the remedy of osteoporosis and having high safety, by using 24,25-dihydroxycholecalciferol as an active component. CONSTITUTION:The objective agent contains the 24,25-dihydroxycholecalciferol of formula [24,25-(OH)2-D3] as an active component. There are many potential causes of osteoporosis, e.g. endocrinic cause, nutritional cause, physical cause, genetic cause, etc., and above all, the postmenopausal osteoporosis takes the largest portion. The present drug is effective not only to the postmenopausal osteoporosis but also to the osteomalacia osteoporosis complicated with osteomalacia, the secondary osteoporosis complicated with accessory thyroid function exasperation, etc., the local osteoporosis of arthrorheumatism, and the abnormality in the bone. The component is especially preferably 24R,25-(OH)2-D3 of formula II. The agent is free from the side effect of hypercalcemia inherent to the conventional active vitamin D3 preparation, and has extremely high safety.
Nearly 4 billion people live in a dengue risk area worldwide. The prevalence of dengue-related mucocutaneous manifestations and their association with severe dengue differ across studies. The aim of the study was to describe the characteristics of patients with dengue-related mucocutaneous manifestations and to investigate those were associated with severe dengue. A retrospective study was conducted in 2019 among patients with a positive RT-PCR for dengue at the University Hospital of Reunion, which has been experiencing a re-emergence of dengue since 2018. Of 847 patients with confirmed dengue, 283 (33.4%) developed mucocutaneous manifestations. Only manifestations of dehydration such as glossitis, dysgeusia, or conjunctivitis were associated with severe dengue, unlike pruritus and rash, in bivariate analysis but not in multivariate analysis. The rash and pruritus of dengue appear to be accompanied by a pronounced flu-like syndrome in younger people without comorbidity or severity, although careful examination of mucous membranes would better identify signs of dehydration and thus cases likely to worsen.
The invention discloses an anti-flavivirus envelope E protein monoclonal antibody and application thereof. The anti-flavivirus envelope E protein monoclonal antibody of the invention is secreted by a mouse source hybrid tumour cell strain D2-2A10G6 with the preservation number of CGMCC No. 3292. The anti-flavivirus monoclonal antibody of the invention can be specifically combined with the function epitope of flavivirus envelope E protein. The amino acid sequence of the functional epitope of envelope E protein is SEQ ID NO: 17. The monoclonal antibody of the invention is subject to screening by indirect immunofluorescent method, and indirect enzyme-linked immunization is used for evaluating the specificity and affinity when being combined with antigen. By adopting the monoclonal antibody or immunoconjugate of the invention, flavivirus infection cell can be blocked and suckling mouse can be protected from virus attack, thus achieving the effect of inhibiting virus infection. The monoclonal antibody or immunoconjugate of the invention also can be used for flavivirus envelope E protein detection.
BACKGROUND: Growth references play a crucial role in the screening, evaluation, and surveillance of children, aiding in the early identification of the requirement for diverse growth-promoting interventions. Variations in human growth across distinct ethnic cohorts arise from genetic disparities, lifestyle variances, nutritional diversity, and diverse social and environmental contexts. Consequently, the selection of growth references markedly influences the prevalence of developmental disorders and nutritional imbalances in children. The study aims to assess the growth percentile of children in the north-east of Iran and establish population-specific reference charts for length, weight, and head circumference spanning from birth to 24 months.
METHODS: This cross-sectional population-based research conducted in the north-east of Iran, from 2016 to 2023. The Data extracted from the electronic health records of Mashhad University of Medical Sciences. All apparently healthy children aged from birth to 24 months who were measured at least once by health staff at the ages of birth,1,2,4,6,7,9,12,15,18,24 months were included. The target population of the study were 479,089 children (96.21%), encompassing 233,565 girls (48.75%) and 245,524 boys (51.25%). Gender-specific percentile curves for length, weight, and head circumference concerning age, as well as weight concerning length, were derived using the GAMLSS approach.
RESULTS: From the anthropometric information of 479,089 children (245,524 boys and 233,565 girls), growth charts were constructed. In comparison to the standard WHO chart, Iranian neonates displayed lower weight across all percentiles during the first month after birth, exhibited decreased head circumference at the 3rd percentile, and boys showed reduced length across all percentiles. After this age, Iranian children demonstrated increased weight, length, and head circumference.
CONCLUSIONS: This research introduces the inaugural large-scale endeavor for indigenous reference charts. Through the noted distinctions from the international reference, the utilization of this novel resource offers the potential to enhance the surveillance of children's growth within the area. Moreover, by accurately assessing growth anomalies such as underweight, stunting, and wasting, it expands the domain of impactful policies in this sphere. Simultaneously, it enables the exploration of the secular trend of children's growth in the forthcoming years.
The invention relates to a pure plant moisturizing facial cleanser. The invention belongs to the technical field of daily facial cleansers. The facial cleanser comprises components of, by mass: 20 to 30 parts of pure natural plant chamomile, 10 to 15 parts of aloe gel, 3 to 8 parts of lavender essential oil, 5 to 10 parts of sweet almond oil, 3 to 5 parts of green tea, 10 to 15 parts of radix notoginseng, 5 to 10 parts of coconut oil, 10 to 15 parts of natural propolis, 5 to 10 parts of fresh milk, and 10-15 parts of pure water. No chemical substance is added to the formula provided by the invention. The materials of the facial cleanser are extracted from natural plants. The facial cleanser is gentle to the skin, and causes no irritation. The facial cleanser provides an effect of moisturizing. With the facial cleanser, rich foam can be produced, and the cleansing capacity is high. Natural propolis is rich in physiologically active substances, and provides a natural health care effect on skins.
The invention relates to disinfectant compositions, containing (a) at least one amine and/or quaternary ammonium salt of the general formula (Ia) or (Ib), wherein R1 represents C¿6-18? alkyl, R?2¿ represents benzyl or C¿6-18? alkyl, R?3¿ represents C¿1-18? alkyl or-[(CH2)2-O]nR?6¿, where n=1-20, R?4 and R5¿ independently of one another represent C¿1-4? alkyl, R?6¿ represents hydrogen or optionally substituted phenyl and A- is a monovalent anion or the equivalent of a multivalent anion of an inorganic or organic acid; b) at least one alkanolamine of the general formula (II), wherein m and, if present, o and p independently of one another have the values 2 or 3 and x and y independently of one another have the values 0 or 1, or a corresponding salt. The mass ratio of the components in the formulas (I):(II) is between 20:1 and 1:20. The inventive compositions are characterised by an excellent bactericidal and in particular fungicidal action even in small application concentrations and are suitable for use as both disinfectants and preservative agents.
During liver fibrogenesis, the reciprocal crosstalk among capillarized liver sinusoidal endothelial cells (LSECs), activated hepatic stellate cells (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating the disease condition and weakening therapeutic effect. Limited by the malignant cellular interactions, the previous single-cell centric treatment approaches show unsatisfactory efficacy and fail to meet clinical demand. Herein, a vicious cycle-breaking strategy is proposed to target and repair pathological cells separately to terminate the malignant progression of liver fibrosis. Chondroitin sulfate-modified and vismodegib-loaded nanoparticles (CS-NPs/VDG) are designed to efficiently normalize the fenestrae phenotype of LSECs and restore HSCs to quiescent state by inhibiting Hedgehog signaling pathway. In addition, glycyrrhetinic acid-modified and silybin-loaded nanoparticles (GA-NPs/SIB) are prepared to restore hepatocytes function by relieving oxidative stress. The results show successful interruption of vicious cycle as well as distinct fibrosis resolution in two animal models through multiregulation of the pathological cells. This work not only highlights the significance of modulating cellular crosstalk but also provides a promising avenue for developing antifibrotic regimens.
This cohort study used prospectively collected data from the Swedish national quality registry, SwedAD, to investigate weight gain as a possible side effect of dupilumab treatment for atopic dermatitis. Patients on dupilumab were compared with patients on other systemic medications, e.g., methotrexate, cyclosporine, or Janus kinase inhibitors, and possible risk factors for weight change during treatment with dupilumab were analysed. All patients aged 18 years or above, included in SwedAD between March 2018 and April 2023, who initiated systemic treatment at or after inclusion and had data on weight at baseline and at least 1 follow-up weight measurement were included (n  =  157). After 2 years on dupilumab, patients had a mean weight gain of 1.6 kg (p = 0.007, 95% confidence interval [CI] 0.4-2.7). In the multivariable analysis, controlling for age at start, sex, asthma, and body mass index at start, dupilumab was associated with higher weight gain than other systemic treatments (3.3 kg, p = 0.005 [95% CI 1.0-5.6]). Asthma was associated with weight loss; male sex tended to be associated with weight gain.
There is only one arm to the study. All subjects will receive NicVax, \[123I\]5-I-A-85380,and Nicotine bitartrate.
Evolution has fostered robust DNA damage response (DDR) mechanisms to combat DNA lesions. However, disruptions in this intricate machinery can render cells overly reliant on the remaining functional but often less accurate DNA repair pathways. This increased dependence on error-prone pathways may result in improper repair and the accumulation of mutations, fostering genomic instability and facilitating the uncontrolled cell proliferation characteristic of cancer initiation and progression. Strategies based on the concept of synthetic lethality (SL) leverage the inherent genomic instability of cancer cells by targeting alternative pathways, thereby inducing selective death of cancer cells. This review emphasizes recent advancements in structural investigations of pivotal SL targets. The significant contribution of structure-based methodologies to SL research underscores their potential impact in characterizing the growing number of SL targets, largely due to advances in next-generation sequencing. Harnessing these approaches is essential for advancing the development of precise and personalized SL therapeutic strategies.
PURPOSE:To improve resistance to water, perspiration and sebum by preparing an emulsion composition by mixing an outer phase contg. fluorine modified silicone compound, an inner phase contg. water or alcohol and a lipophilic surfactant. CONSTITUTION:An emulsion composition is prepd by mixing an outer phase (component A) contg. at least one kind of fluorine modified silicone compounds shown by the formula I (wherein (n) and (m)are the average of 1-150 and 0-150, respectively, (a) is an integer of 0-5 and Rf represents 1-8C perphloroalkyl group) an inner phase (component B) contg. water and/or alcohol and lipophilic surfactant (component C). The above mixture is made, preferably with the ratio of the components A to B ranging from 5:1 to 1:5 and with the component C added thereto in an amt. of 0.5-20wt.% (per emulsion composition). As a suitable example for the component C, 14-22C sorbitam monofatty acid ester is available.
BACKGROUND: Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of chronic inflammation with consequent metabolic disturbances. This study evaluated the association of NE and PR3 with GDM development and adverse fetal outcomes.
METHOD(S): This was a prospective cohort study. Serum PR3 and NE concentration was measured in all enrolled pregnant women in the first and the second trimester to determine the connection between NSPs and GDM and adverse fetal outcomes. Logistic regression, spline regression and linear regression analyses were applied to investigate the association of NE or PR3 with GDM development and adverse fetal outcomes. The concentration of NE and PR3 in placental biopsies was evaluated by semi-quantitative analysis of immunohistochemistry staining.
RESULT(S): NE or PR3 concentration in the first trimester, rather than the second, increased more significantly in women with GDM than in those without, regardless of pre-pregnancy body mass index and age. There was a stepwise increase in GDM occurrence as well as comprehensive adverse fetal outcomes across tertiles of NE and PR3. NE and PR3 were positively associated with neutrophil count, pre-pregnancy BMI, plasma glucose level and newborn weight. Logistic regression revealed NE or PR3 to be independent risk factors for the development of GDM and comprehensive adverse fetal outcomes. Spline regression showed a significant increased risk of GDM occurrence and comprehensive adverse fetal outcomes when serum NE concentration exceeded 417.60 ng/mL and a similar result for PR3 and GDM occurrence when the latter exceeded 88.52 ng/mL. Immunohistochemistry data confirmed that enriched NE and PR3 content in placental tissue may have contributed to the development of GDM.
CONCLUSION(S): This work demonstrates that excessive first-trimester NE and PR3 increase the risk of GDM development and comprehensive adverse fetal outcomes.
Spinocerebellar ataxia 3 (SCA3) is a rare form of inherited neurodegenerative disease involving progressive degeneration of spinocerebellar tract. SCA3 is characterised by increasingly worsening cerebellar function leading to gait abnormalities and poor coordination, dysarthria, and abnormal eye movements. Non-ataxia features include pyramidal and extrapyramidal manifestations, sensorimotor, neuropsychological and psychiatric symptoms. This is attributed to the role of cerebellum in motor, cognitive and affective processing (i.e. cerebellar cognitive and affective syndrome; CCAS), as well as its extensive connection with cerebral structures.

Trehalose is an omnipotent disaccharide molecule found in lower and higher life forms except in vertebrates. It has an amorphous (i.e. non-reducing) property, which is shown in its high hydrophilicity, chemical stability and strong resistance to denaturation / breakdown by heat, acid or enzyme. It is also shown to help refold partially denatured protein, thereby stabilizes protein aggregates, including those of polyglutamine, in vivo as well as in vitro. This has provided an avenue in which trehalose as a therapeutic agent for neurodegenerative disorders with pathological changes of protein aggregates.

In this study, a double-blinded randomised controlled trial (RCT) will be employed. A total of 40 patients with SCA3 will be randomly allocated to oral trehalose group and a placebo group (20 participants for each arm). With regards to clinical outcomes, motor and cognitive performances will be assessed to infer the efficacy of trehalose. Likewise, structural, resting-state fMRI (i.e. functional connectivity), and MR spectroscopy (i.e. metabolism), will be used as imaging biomarkers in this study.
INTRODUCTION: Postoperative delirium in older people may result from the interaction between intrinsic brain vulnerability (e.g. neurodegeneration) and precipitating factors (e.g. surgery induced cytokines). Intrinsic brain vulnerability may be overt (e.g. Alzheimer's disease) or preclinical. In cognitively intact older people presenting for surgery, identification of preclinical neurodegeneration using bedside tools could aid postoperative delirium risk stratification. Thinning of the circumpapillary retinal nerve fibre layer thickness is associated with neurodegenerative disorders e.g. Alzheimer's disease. We propose that thinning of the retinal nerve fibre layer may be present some older people with postoperative delirium due to preclinical neurodegeneration, albeit to a lesser extent than in overt dementia.
OBJECTIVES: The primary objective: Feasibility of acquiring usable retinal images with the hand-held optical coherence device, at the bedside of older, hip fracture surgery patients. Secondary objective: Comparison of the circumpapillary retinal nerve fibre layer thickness between people who did/did not have postoperative delirium. Proportion of exclusions due to retinal pathology.
METHOD: Feasibility study involving 30, cognitively intact, older people recovering from hip fracture surgery. Retinal images were obtained using the hand-held optical coherence tomography device at the participants' bedside. Imaging was deferred in participants who had postoperative delirium.
RESULTS: Retinal images that could be assessed for circumpapillary retinal nerve fibre layer thickness were obtained in 26 participants (22 no postoperative delirium, 4 postoperative delirium). The mean circumpapillary retinal nerve fibre layer thickness was lower in the participants who had postoperative delirium compared to those who did not experience postoperative delirium (Mean (95% CI) of 76.50 (62.60-90.40) vs 89.19 (85.41-92.97) respectively).
CONCLUSION: Retinal imaging at the patient's bedside, using hand-held OCT is feasible. Our data suggests that the circumpapillary retinal nerve fibre layer may be thinner in older people who experience postoperative delirium compared to those who do not. Further studies are required.
After enrollment patients receive 'Health Education'. Then patients receive weekly follow up monitoring over phone call for 3 months. After 3 months, patients are requested to visit the Primary Health Care Center (PHC) for follow-up by physician and lab test. From 4-6 months, they receive bi-weekly follow up over phone call and at the end of 6 month, group evaluation for 1 hour and endline data will be collected by the nurses at the PHC.
Multisensory reading strategies, which recruit one or more of the five senses, are routinely used in general education classrooms as well as with children who are struggling readers. Despite their wide use in schools, little research exists to substantiate the utilizing these strategies to enhance literacy. One type of multisensory reading strategy, articulatory gestures, is of particular interest to speech-language pathologists (SLPs) as they are uniquely positioned to provide speech sound placement cues. Limitations of the few prior studies that exist have prevented the isolation of the articulatory gestures themselves as the main contributor to the gains seen in literacy. This study aims to control for factors such as motivation, engagement, and time on task to explore the specific contribution of articulation strategies during phonemic awareness training on phoneme segmentation, reading of phonemically spelled words, and nonword reading in typically developing four-year old children. Using an experimental design, participants will be randomly assigned to one of three conditions: 1) phonemic awareness training with articulatory gestures, 2) phonemic awareness training with general mouth pictures, and 3) phonemic awareness training with no mouth/articulation pictures at all. Interventions will focus on phoneme-letter correspondence and phonemic segmentation using strategies specific to each group and differences between groups will be considered for pre and posttest measures.
To provide analysis of images for clinical use.SOLUTION: In some embodiments, a process and a system are provided for generating a user interface for classification of a sample image of a cell. The classification includes receiving a sample image of a sample particle from a biological sample, and selecting reference images that each portray a reference particle of a biological sample. The reference images can be ordered based on similarity, and the reference images can be selected based on the order. A first selected reference image can be aligned with the sample image and expanded such that the adjacent edges of the reference image and sample image are the same. The expanded image can be dynamically filled. The sample image and the expanded reference image can be displayed in a user interface.SELECTED DRAWING: None
Participants will perform an instructor-led mind-body exercise regimen 1 day per week during this arm of the study for a total of 8 weeks. Home practice will be logged. At the completion of the TCMMMRT Condition, participants will perform an instructor-led low impact aerobic exercise regimen 1 day per week for a total of 8 weeks. Home exercise will be logged.