anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a medicine composition. The medicine composition is composed of a gastric acid secretion inhibitor, antibiotics and vitamin U. Due to the synergistic effect of the vitamin U and other several kinds of medicine, the fact that peptic ulcer is healed and pylorus helicobacter is eradicated through the medicine composition is superior in the fact that compared with the prior medicine composition which does not contain the vitamin U. A side effect can be reduced. Possibility of the occurrence of chemical reaction exists among each component in the medicine composition. Dry particles or enteric micropelets are firstly made from parts of the components. The medicine composition can be used for producing the medicine for curing the peptic ulcer combining the pylorus helicobacter infection.
The investigators plan to study the response to influenza vaccines much more broadly and deeply across different age groups and with different vaccine formulations and to probe the influence of genetics on these responses using monozygotic and dizygotic twins. On an investigational basis, investigators plan to compare various immunological responses, identify age-specific biomarkers or clusters of markers, quantify the frequency of influenza-specific T-cells pre- and post-vaccination, and determine the effective breadth of T-cell repertoire to an influenza vaccine within an individual as a function of age and to what degree this is genetically determined.

Twin Groups A-E will receive a single administration of the 2010-2011 formulation of seasonal trivalent inactivated influenza vaccine (TIV). Group F, elderly monozygotic twin participants, will be randomly assigned to receive a single dose of inactivated vaccine, either the usual dose or the High-Dose TIV. Blood samples to conduct the assays described will be taken at pre-immunization, Days 7-10 and 28 post-immunization. Each twin is counted as a single participant. All reporting numbers reflect the number of participants, not the number of twin pairs.
The aim of this study was to examine the impact of maternal obesity on the reproductive capacity of the female offspring (F1) and on the early development of the second generation (F2). To this end, rats were fed either standard (SD) or cafeteria (CD) diet. CD rats and their offspring were divided into 2 groups: rats with 18% and ≥25% overweight (CD18 and CD25, respectively) and offspring from CD18 and CD25 rats (OCD18 and OCD25, respectively). Both OCD groups achieved greater weight gain than controls, without changes in the serum levels of glucose, cholesterol or triglycerides. However, they showed increased gonadal cholesterol concentration and fat content compared to controls. Female OCD groups showed a slight prolongation of the estrous cycle and different pattern of changes in the weight gain during pregnancy. The OCD25 group displayed an increased fertility index and preimplantation losses, and changes in some fetal measurements. Some OCD25 dams gave birth to a larger litter of pups and displayed a lower viability index and lactation rate than controls. OCD25 dams also showed an increase in estradiol and a decrease in testosterone and anti-Müllerian hormone. OCD25 rats showed increased mRNA levels of steroidogenenic enzymes. The offspring from OCD25 females (F2OCD25 offspring) showed early vaginal opening and higher ovulation rate in females, and lower ano-genital distances in males, compared to controls. In conclusion, these results reflect that maternal obesity impacts on the reproductive health of successive generations, probably as a result of epigenetic changes in different systems, including germ cells.
The invention discloses an epidemic situation monitoring and emergency disposal device and system. The invention has the beneficial effects that: 1. the identity of personnel is identified through the face identification system, the body temperature of the personnel is rapidly detected through the body temperature monitoring system, and the identity information and the body temperature information of the abnormal body temperature personnel are sent to the cloud data center; and emergency disposal materials are provided for abnormal body temperature personnel and surrounding personnel through the epidemic situation monitoring and emergency disposal device, and corresponding help is provided for monitoring of the epidemic situation and subsequent tracing and control. 2. The invention can also be added into an attendance system to provide personnel attendance service for units. 3. The goods delivery bin is internally provided with a disinfection device, and after personnel take emergency treatment materials, the goods delivery bin is disinfected.
A system prevents the creation of duplicate records and identifies, groups, and consolidates duplicate records and manages the associated workload. A method consolidates multiple records that are associated with a single entity and are stored in at least one record repository. The method involves identifying first and second records and applying record matching criteria to compare data element content of the first and second identified records to determine commonality data. The commonality data is indicative of a likelihood the first and second records are associated with a common entity. The first and second record content is merged into a composite record in response to the determined commonality data. One of the first and second records are selected as a surviving record based on earliest date of record creation or relative content of the first and second records.
A URL processing system and associated communication protocol enables network compatible applications to be securely integrated into any process involving concurrent operation of applications. A system employed by an application for encoding URL link data for use in detecting unauthorized URL modification includes a link processor for processing URL data. The link processor adaptively identifies and encrypts an address portion of a URL and incorporates the encrypted address portion of the URL together with the non-encrypted portion of the URL into a single processed URL data string. The system also includes a communication processor for incorporating the processed URL data string into formatted data for communication to a request device. The link processor compresses the identified URL address portion (e.g., with a hash function) prior to encryption. A system for decoding encoded URLs applies a hash function to a corresponding URL derived from a source different to the source of the received URL to provide a second hash value for comparison with a first received hash value for URL validation.
As rates of opiate misuse rise in the United States, there areso do significant associated health, and financial consequences to afflicted individuals, their families, and society at large. Methadone Maintenance Therapy (MMT) is one evidence-based approach to treating individuals with opiate addiction, yet supplemental psychosocial treatment to support this approach is lacking. Mindfulness-Based Relapse Prevention (MBRP) has shown to be efficacious in various substance use populations, but has yet to be assessed with MMT clients. The current study was designed to inform protocol adaptation for to MMT clients, and to evaluate the feasibility, acceptability, and preliminary efficacy of a MBRP for this population. The sample consisted of adults (N=15) recruited from a methadone clinic to participate in a 6-week MBRP course. Indices of feasibility, including recruitment, retention, data from focus groups and course satisfaction surveys, supported feasibility of the intervention. Outcome measures were self-report, and included self-compassion, depression, craving, PTSD symptoms, and experiential avoidance, and were assessed at baseline, postcourse, and 1-month follow-up. Data were analyzed using qualitative and quantitative approaches. Mean scores on all primary outcomes changed in the expected direction at both postcourse and 1-month follow-up assessment, although only depression and experiential avoidance reached significance. Results from this initial pilot support feasibility and acceptability, and provide preliminary data on outcomes for future trials of mindfulness-based approaches within the MMT community.
Most gestational diabetes mellitus (GDM) can be well controlled by health education and life style management, expecting a better pregnancy outcome. But standard clinic prenatal care which consist of clinic visit every two weeks may not give full play to the effects of GDM management. Telemedicine shows its potential to fill this gap. A multicenter, randomized controlled trial was designed to investigate whether health education and life style management through WeChat group chat was more effective in controlling blood glucose (BG) than standard clinic prenatal care in women with GDM. Women with GDM diagnosed by oral glucose tolerance test between 23-30+6 gestational weeks were randomized to a WeChat group chat-based blood glucose management group or routine clinic prenatal care. In PUMCH, investigators also equip CGM for m-health group allowing a more detailed BG information. The primary outcome was change of glycemic qualification rate during follow up period in both groups. The second outcome was pregnancy outcomes. Also, a case-control study is designed to compare the glucose control status between rice-richen meal and wheaten-richen meal, and all other macronutrients and micronutrients are all calculated and same between two groups, which may provide more clues for type of carbohydrate recommendation for Chinese women with GDM.
Participants will receive the intervention first. Caregivers will attend a one-off training session on how to deliver the intervention. Then the participants will follow the sessions in the intervention manual (8 sessions weekly).
To report the frequency of hyphema after PRESERFLO® MicroShunt (PMS) surgery using double-step knife in patients with glaucoma and to investigate its relationship with the tube insertion position. Glaucoma patients who underwent PMS surgery were reviewed. Hyphema was defined as visible hemorrhage in the anterior chamber. The insertion position of PMS was confirmed via gonioscopy. Patient backgrounds in the hyphema and non-hyphema groups were compared, and the course of visual acuity (VA), intraocular pressure (IOP), and time to resolution of hyphema were investigated. 65 of 66 eyes were eligible for consideration. Hyphema had occurred in 23 (35%) eyes. At the end of surgery, anterior chamber bleeding was observed under the microscope in 8 of 23 cases (35%). The tube fixation position was on the scleral spur (25 eyes), on the trabecular meshwork (27 eyes), on the Schwalbe line (10 eyes) and on the corneal side (3 eyes). There was no significant difference of the site of tube insertion between the two groups. All cases of hyphema spontaneously resolved within a few weeks, with stable IOP and recovered VA. It is worth noting that in PMS surgery using the double-step knife, hyphema may occur high frequency even if the tube insertion site is accurately positioned. Patients should be informed of the risk of hyphema before the surgery.
PCT No. PCT/US82/00763 Sec. 371 Date Jun. 3, 1982 Sec. 102(e) Date Jun. 3, 1982 PCT Filed Jun. 3, 1982 PCT Pub. No. WO83/00018 PCT Pub. Date Jan. 6, 1983.There is disclosed a novel immunogen which can be used for immunological protection against acute diarrheal disease caused by enterotoxigenic strains of Escherichia coli. The novel immunogen is provided by cross-linking the E. coli heat-stable enterotoxin with the E. coli heat-labile enterotoxin (either the complete holotoxin or just the B subunit of this toxin) by a conjugation process in the presence of a conjugating agent, typically the water soluble carbodiimide, 1-ethyl-3-(3-diamethylaminopropyl) carbodiimide. This results in a unique new molecule in that the toxic properties of each individual toxin are greatly reduced, the heat-labile toxin (or its B subunit) retains its antigenicity, and the heat-stable toxin acquires immunogenicity as a function of the reaction. Immunization with the cross-linked immunogen provides immunological protection in mammals against water secretion induced by strains of E. coli which produce the heat-labile or heat-stable enterotoxins, either singly or together.
BACKGROUND: With the introduction of novel surgical robots and surgical microscopes for the special needs of open microsurgery, the concept of robotic-assisted microsurgery is gaining popularity. While initial preclinical studies indicate a steep learning curve, favourable ergonomics and improved precision, albeit with an increased operating time, data on the clinical application of the new systems is still limited. This study describes our first clinical experience with robotic-assisted autologous breast reconstruction and outlines the opportunities and limitations of the approach.
PATIENTS AND METHODS: Our retrospective data analysis included a total of 28 patients who underwent unilateral robotic-assisted autologous breast reconstruction between July 2022 and August 2023. We applied a combined approach using the Symani Surgical System together with the RoboticScope. Descriptive evaluation of patient characteristics, surgical data and complications was performed.
RESULTS: Average patient age was 54.3±11.1 years and average BMI was 26.5±3.5 kg/m2. Twenty-six patients received a DIEP flap and 2 patients received a PAP flap, the flaps being connected to the internal mammary artery in 22 cases, to a perforator of the internal mammary artery in 5 cases, and to a branch of the thoracodorsal artery in one case. The average incision-suture time was 267±89 min, with an average ischaemia time of 86±20 min and duration of the arterial anastomosis of 29±12 min. In two cases, immediate intraoperative anastomosis revision was performed, but no flap loss occurred.
CONCLUSION: The results of this study demonstrate the safe feasibility of robot-assisted autologous breast reconstruction using a combination of Symani and RoboticScope. In the future, special attention should be paid to minimally invasive techniques of flap harvest and connecting vessel preparation.
Hemangioblasts in adult bone marrow participate in new blood vessel formation. By modulating the differentiation of hemangioblasts into blood vessel cells, angiogenesis in a particular tissue can be increased or decreased. The present invention features compositions and methods for reducing tumor vasculogenesis, treating leukemia, and/or treating or preventing leukemia relapse. In particular, the invention provides an SDF-1 binding agent (e.g., antibody, antisense, ribozyme) for the treatment or prevention of a neoplasia, such as leukemia. Intravitreal injection of antibodies that block SDF-1 activity inhibited induced retinal neovascularization mediated by hemangioblasts. Anti-SDF-1 ribozymes and SDF-1 anti-sense RNA expression constructs significantly reduced migration of cells that create new vessels in the eye.
The posterior acetabular wall fracture is one of the simpler acetabular fracture patterns and the most common type, accounting for approximately one quarter of all acetabular fractures. Most patients achieve excellent outcomes after anatomical reduction and rigid internal fixation with standard screws and buttress plates.However,it is well known that the reconstruction plate need remould in the surgery. So it does not only lead to the extension of operation time, but also cause poor attach of acetabular posterior wall. Moreover, the angulation of the screw placement for the holes of the reconstruction plate in the danger zone was determined with only caution. The intraoperative fluoroscopy was employed frequently to help determine the periacetabular screw location. If the operator lack of experience, intraarticular screw penetration and prolonged operative duration is inevitable. The investigators now introduce a new type of internal fixation device of acetabular posterior wall fracture that improve the shortcomings of existing technology.The plate itself can be thought to consist of three regions: the iliac region, the danger zone region, and the ischial tuberosity region. The organization of these regions causes the plate to resemble the English alphabet letter ''W''.The contour and zygomorphy of the W-shaped plate matched the surface of the posterior column of the acetabulum. There are two rows of drill holes in the danger zone region. A special safe-angled drilling guide was used to assist in the operation. A retrospective study has been indicated that this kind of new plate produce good results. This device may help to avoid intraarticular screw penetration and reduce operative duration and blood loss. The device further provides a stable fixation of the posterior wall that is amenable to early range of motion and weight bearing postoperatively, and results in a good clinical outcome.
The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a preparation method of active total diterpene in a Thymelaeaceae plant and application thereof in pharmacy. The present invention relates to a method for enriching total diterpene components from Daphne genkwa (Daphne genkwa sieb. et Zucc), Wikstroemia canthus Wikstroemia canescens (Wall.) Meisn) and pseudo-langdu root (Stelleropsis tienschia Pobed) belonging to Thymelaeaceae (Thymelaeaceae), and the content of the main active component and anti-HIV activity of each component are measured. When the total diterpene content in the enriched component is more than 64 percent, the enriched component shows extremely strong anti-HIV activity, the EC50 value can reach 0.0047 mu g/mL, the Selection Index (SI) is more than 2000, the enriched component has high efficiency and low toxicity, and has obvious advantages compared with a positive control medicament zidovudine. The invention establishes a method for rapidly enriching the total diterpenoids from the Thymelaeaceae plants, the method is simple, the process is reasonable, the recovery rate is high, and the enriched total diterpenoids can be used for preparing anti-HIV drugs.
PURPOSE:To enable immediate quantitative determination of a specimen without culture by incroporating the antibody prepd. from the certain strain in the microorganism to be quantitatively determined and the insolubilized somatic component of the strain which conjugates thoroughly with said antibody but does not hinder the conjugation of the other strains and said antibody into a reagent. CONSTITUTION:A reagent for quantitative determination of microorganisms contains (a) an antibody prepd. from the certain strain in the microorganism to be quantitatively determined, (b) the insolubilized somatic component of the strain which conjugates thoroughly with said antibody in said microorganism but does not hinder the conjugation of the other strains and said antibody and (c) the component of the antibody labeled for said antibody. An excess and known amt. of the antibody (a) is added to a specimen contg. the microorganism to be quantitatively determined to effect antigen antibody reaction. The insolubilized antigen (b) is further added to effect reaction with the remaining antibody failing to react with the antigen in the specimen. The antibody- (b) complex is separated and the antibody (c) is added thereto. Labeling activity is measured after washing, by which the quantity of the antibody in the solid phase is known. The quantity of the antibody in the liquid phase is known therefrom and therefore the quantity of the microorganism in the specimen is determined.
The present invention provides combination therapy that includes an KRAS<sup>G12C </sup>inhibitor, such as (see Formula), or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRAS<sup>G12C</sup> inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.The present invention provides combination therapy that includes an KRAS<sup>G12C </sup>inhibitor, such as (see Formula), or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRAS<sup>G12C</sup> inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers. An indoor geolocation system for determining a location in three-dimensional space includes a plurality of base stations and a mobile device movable about an indoor environment in three dimensions. The mobile device detects electromagnetic signals in the indoor environment emitted by devices other than the base stations, and generates a signal profile based on the signals. The mobile device transmits the signal profile to one or more of the base stations, which forward the signal profile to a remote server. The system determines a location of the in three- dimensional space of the mobile device by comparing the signal profile to data regarding signal profiles at a plurality of locations in the indoor environment. The data regarding signal profiles in the indoor environment may have been captured by a detection device other than the mobile device at a time prior to the detection of the electromagnetic signals by the mobile device.
Patients randomly enrolled in this group will receive 10 sessions of anodal HD-tDCS stimulation on cortical representation zone of left diaphragmatic motor cortex associated to respiratory training; for 20 minutes (each session) with a 2mA intensity. The electrical current will be delivered with a ramp-up time of 30 s, held at 3mA for 20 min, and then ramped down over 30 s.
BACKGROUND: Anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4Ab+NMOSD) is an inflammatory disorder of the central nervous system with relapse-dependent progression. Few studies have reported the effects of prednisolone and biologics on disability progression in AQP4Ab+NMOSD, although it is established that they prevent clinical relapses. This retrospective study investigated long-term disability progression and the effects of therapeutic interventions on disability progression in AQP4Ab+NMOSD.
METHODS: This study included a total of 101 patients with AQP4Ab+NMOSD. Disease progression was investigated in the following two cohorts: (1) duration from disease onset to Expanded Disability Status Scale (EDSS) 3.0 in patients who did or did not receive oral prednisolone or biologics before reaching EDSS 3.0 and (2) duration from disease onset to EDSS 6.0 in patients who did or did not receive oral prednisolone or biologics before reaching EDSS 6.0.
RESULTS: Approximately half of the untreated patients reached EDSS 3.0 and 6.0 at 10 and 46 months after disease onset, respectively. In addition, 88% and 71% of the untreated patients reached EDSS 3.0 and 6.0 within 10 years after disease onset, respectively. Disability progression, clinical relapses and attack severity were suppressed by prednisolone and biologics.
CONCLUSIONS: AQP4Ab+NMOSD is a severely disabling disease. Treatment interventions using prednisolone and biologics are useful in suppressing disability progression in AQP4Ab+NMOSD.
For patients in this arm, daily measurements from the device will be revealed to the treating physician. Discharge can be planned when the clinical stability is achieved and the ReDS value is ≤35%. In case of a ReDS value \>35%, treating physicians will follow a predefined algorithm before discharge to improve the results of ReDS test.