anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Procedure for the obtaining of derivatives of phosphinic and phosphonic acids and of their salts, of formula (I), in which r is rent and r is hydrogen or lower rent, or together with the carbon atomo to which they are united form a cyclocal ring c <003>; r and r are lower rent; and x is hydrogen, hydroxyl, rent or aril. It consists in the reaction of a compound of formula (II) with a cetone of formula r cor, in which all symbols have the same meaning as in formula (I). The reaction is carried out in an aqueous-organic medium, at the reflux temperature of the reaction mixture. Diastereomeric mixing can be separated diastereomeric racematos or resolve the optical isomers. These compounds have pharmacological applications for the treatment of inflammatory states, degenerative articular diseases and wilson's disease. (Machine-translation by Google Translate, not legally binding)
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. The beneficial effects of lisinopril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase of serum potassium. In hypertensive patients with normal renal function treated with lisinopril alone for up to 24 weeks, the mean increase in serum potassium was approximately 0.1 mEq/L; however, approximately 15% of patients had increases greater than 0.5 mEq/L and approximately 6% had a decrease greater than 0.5 mEq/L. In the same study, patients treated with lisinopril and hydrochlorothiazide for up to 24 weeks had a mean decrease in serum potassium of 0.1 mEq/L; approximately 4% of patients had increases greater than 0.5 mEq/L and approximately 12% had a decrease greater than 0.5 mEq/L [see CLINICAL STUDIES ( 14.1)] . Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity. 

ACE is identical to kininase, an enzyme that degrades bradykinin. Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of lisinopril remains to be elucidated. 

While the mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, lisinopril is antihypertensive even in patients with low-renin hypertension. Although lisinopril was antihypertensive in all races studied, Black hypertensive patients (usually a low-renin hypertensive population) had a smaller average response to monotherapy than non Black patients. 

Concomitant administration of lisinopril and hydrochlorothiazide further reduced blood pressure in Black and non-Black patients and any racial differences in blood pressure response were no longer evident.
Neonate 26 weeks to 36 weeks + 6 days of gestation, without congenital heart defects and/or hemodynamically significant fetal circulation, any respiratory therapy, nor need of supplemental oxygen. Subjects had no clinically and laboratory-identified infections.
The "Kuilyongwon" medicament is prepared by the following method. (1) Powder 93.75    of Korean angelica root, 93.75   of deer antlers and 18.75   of mume fruit flesh in respective or mixed state. Each component is pre-treated and measured before powdering. (2) Degrease the produced powder in nonpolar solvent and obtain the extract. And reflux and extract the residue in low polarizable solvent and obtain the extract. (3) Obtain the extraction liquid from extract residue in solvent mixing alkali inorganic salts as extraction supplementary agent, cyclodextrines as stabilizer and nonionic surfactant with soluble low-level alcohol. (4) Mix the extract from nonpolar solvent, the extract from low polarizable solvent and solvent extraction liquid from halogen hydrocarbon with the obtained low-level alcohol extraction liquid. And concentrate this with decreasing pressure and obtain the herb medicines extract.
The present invention discloses a highly effective annonaceous acetogenins part medicine-idarubicin hydrochloride for injection, the preparation method and application thereof. The principal ingredient comprises alpha, beta-unsaturation gamma-double tetrahydrofuran loop type annonaceous acetogenins compound with lactone structure -bullatacin and shikemoxin. The ingredients of the type account for 90 percent or above of the total mass number. The preparation method of the present invention causes little environmental pollution, is simple and can be easily implemented. Large scale production can be realized. The highly effective annonaceous acetogenins part medicine-idarubicin hydrochloride for injection presented by the invention can be used for preparing medicines for curing malignant tumor, HIV infect/AIDS, resembling rheumatism, psoriasis and lupus erythematosus autoimmune disease. In the preliminary clinical test of treating malignancy, and HIV infect / AIDS, the idarubicin hydrochloride for injection shows the predominance beyond compare of the Chinese and Western medicine medication.
Report of pancytopenia including aplastic anemia have been reported with TNF blocking agents. Cases of leukopenia, neutropenia, thrombocytopenia, and pancytopenia, some with a fatal outcome, have been reported in patients receiving infliximab products. Clinically significant events of neutropenia were noted in the clinical trials of ZYMFENTRA. The causal relationship to infliximab product therapy remains unclear. Although no high-risk group(s) has been identified, avoid ZYMFENTRA in patients who have ongoing or a history of significant hematologic abnormalities. Advise all patients to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias or infection (e.g., persistent fever) during treatment with ZYMFENTRA. Consider discontinuation of ZYMFENTRA therapy in patients who develop significant hematologic abnormalities.
A digital web-based education platform is provided for delivering targeted and individual training (e.g., to patients on injection technique to help with medical condition management). An associated website is accessible by users via computers and mobile devices. The platform has several short learning modules (e.g., animations, videos that can include knowledge assessment) on various topics. Healthcare providers (HCPs) can prescribe or recommend which topics each patient should follow and prescribes a selected product having a code. Patients access the learning modules using the website by entering the code found in the box or packing for a product, or provided by an HCP, and review learning modules and topics of their choice or recommended by an HCP using a product code and the website URL. The platform collects patient usage data and metrics that can be used to provide incentives to patients,
Oral teriflunomide was given at a starting dose of 7 mg once daily and danazol was given at a dose of 200mg twice daily for 24 weeks. Treatment was discontinued if very severe or life-threatening adverse events developed or at the patient's request.
The proposed research aims to evaluate the effects of a school-based nutrition policy initiative on prevalence, incidence and remission of overweight (BMI \> 95th percentile). It is a partnership between the Food Trust, the School District of Philadelphia and the University of Pennsylvania. Participants are approximately 1500 students from ten schools in grades four through eight. Half of the schools were randomized to a comprehensive School Nutrition Policy Initiative (SNPI) based on CDC's Guidelines to Promote Lifelong Healthy Eating. The SNPI is a community-based intervention administered by the Comprehensive School Nutrition Policy Task Force that is comprised of 40 individuals representing the public and private sectors. The goal of the SNPI is to change the school environment to: support healthy eating, increase physical activity, and decrease the prevalence of childhood overweight and diet-related diseases. The remaining study participants are in five control schools, matched for ethnicity, SES, and type of food service. Most students are African American and qualify for free and reduced meals at school (household income \< 185% of the poverty level adjusted for household size). Assessments of weight, height, intake, activity, inactivity and eating disorder symptomatology are being conducted at baseline and 1 and 2 years.
PURPOSE: Chronic diseases in older age are major sources of burden for healthcare systems. Compliance with medications is the key to treatment success for these patients, especially for frail individuals living in community settings. However, adherence to long-term medications in this population is not optimal, which leads to the need for frequent screening of compliance within large-scale public health surveys. In this context, a brief, simple and valid measure capturing medication adherence is not yet available. This study aims to develop and psychometrically test the Therapeutic Adherence Scale, a brief four-item tool that measures medication adherence in community-dwelling older adults affected by chronic diseases.
METHODS: We conducted a three-phase process of instrument development, content validity assessment and psychometric testing.
RESULTS: Of the candidate nine items derived from a review of the literature, only four were deemed essential to capture intentional and nonintentional nonadherence. These items underwent structural validity, convergent and known-groups validity, and internal consistency on a sample of 269 participants (mean age = 7.91 years, SD = 7.26). Confirmatory factor analysis confirmed satisfactory fit indices (RMSEA = 0.000, CFI = 1.00, TLI = 1.00). Scores of the TAS were higher for those perceiving loneliness (ρ = 0.33, p < 0.001), those declaring memory loss in the last year (ρ = 0.29, p < 0.001), and those exhibiting worse mental quality of life (ρ = -0.15, p = 0.03) compared with the other groups. Cronbach's alpha and split-half reliability coefficients were acceptable, with values of 0.68 and 0.77, respectively.
CONCLUSION: The Therapeutic Adherence Scale is a brief, valid and reliable self-report measure of medication adherence that can be used in practice and research to screen patients living in community settings. This tool is also free to use, which contributes to advancing knowledge on the field of medication adherence of older adults affected by chronic diseases.
Up ontil now, only low reactivity Tzs can be radiolabeled via direct aliphatic S<sub>N</sub>2. Unfortunately, these structures display too low reactivity for in vivo bioorthogonal chemistry approaches. Highly reactive structures such as mono-unsubstituted tetrazines (H-Tzs) have been reported to be highly sensitive to base. Extensive degradation is observed which prevents isolation of meaningful amounts for imaging studies.In the present invention there is provided a method providing the possibility to radiolabel base sensitive tetrazine structures with significantly improved RCYs. Even tetrazines that were previously not accessible by applying "standard" aliphatic <sup>18</sup>F-labeling strategies can be radiolabeled. This places new classes of <sup>18</sup>F-fluorinated compounds within reach for application in PET imaginge studies such as for diagnosis of cancers.
In 40 male U.S. Veterans, who have had chronic mTBI for at least six months, the effect of HBOT will be measured in this pilot study with online questionnaires before and after HBOT to measure mental health issues (e.g. depression) and brain function (e.g. memory). The questionnaires will be repeated at 6 and 12 months after HBOT. Brain SPECT (single-photon emission computerized tomography) scans, will measure blood flow to the brain's injured areas before and after HBOT. Quantitative Electroencephalography (QEEG)) will measure brain electrical signals before and after HBOT. An overnight sleep study will measure the quality and stages of sleep pre- and post-HBOT. Blood tests will measure inflammation and cellular mitochondrial function (energy production by the cell) before and after HBOT.
Many individuals with Alcohol Dependence do not receive treatment, despite effective treatments being available. A significant healthcare challenge is to find ways to bring people who have alcohol dependence into treatment programs. Drinking drivers are a group that has been shown to have high rates of alcohol dependence. In Ontario, all convicted drinking drivers who want to obtain a drivers license must complete Ontario's remedial program for convicted drinking drivers called Back on Track (BOT). In this program, those with more serious alcohol-related problems are assigned to a group treatment program. While it is likely that many of the individual in this group are experiencing alcohol dependence, currently there is no formal linkage to any medical services for these problems. In this study, the investigators will provide those in the BOT treatment group with information about a 24-week study assessing the effectiveness of naltrexone vs. placebo. This study will also assess the feasibility and level of interest among this population to obtain treatment for alcohol dependence.
There are 9 participants currently being followed in the faculty sponsor's clinic that carry the clinical and histologic diagnosis of RRP. The 9 participants meet one or more of the following criteria: Surgery requirement of more than 4 procedures per year, distal multisite spread of disease, and rapid regrowth of papilloma disease with airway compromise.
Disclosed is a compound represented by the general formula (1) below, wherein A is a benzene ring which may be substituted, a salt thereof or a prodrug thereof, which is an effective compound for the prevention and/or treatment of fibrosis. B is an aryl group which may be substituted or a heteroaryl group which may be substituted. X is an oxygen atom or a sulfur atom. Y is a nitrogen atom or a carbon atom. R 1 Independently of one another, lower alkyl, or 2R 1 Can be bonded to each other to form a spiro or bridged structure, or 2R 1 May be bonded to each other and form a saturated fused heterocyclic ring together with the carbon atom and nitrogen atom constituting the ring containing Y. p is 0, 1 or 2. Or (R) 1 ) p Is an oxo group. In that In (1), a single bond or a double bond when Y is a carbon atom, and a single bond when Y is a nitrogen atom.
Participants assigned to the standard care arm will receive standard oncology care and attend regular clinic visits. Participants on the standard care arm will complete questionnaires from baseline up to 6 months following enrollment.
Subjects will be given with a dose of 5 mg/day donepezil. All drugs will be administered orally.
Despite the availability of the human papillomavirus (HPV) vaccine, non-Latinx (NL) Southeast Asian Americans have the highest incidence of HPV-associated cervical cancer in the US. Little is known about NL-Southeast Asian Americans' HPV vaccination coverage due to being categorized under the "Asian American" monolith. Therefore, this study uses restricted data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES) to disaggregate NL-Southeast Asian Americans and compare this population's age-specific probabilities of initiating HPV vaccinations to two Asian American subgroups (NL-East Asian and NL-South Asian Americans) and NL-White, NL-Black, and Latinx Americans. Multinomial logistic regression models examine the differences in the timing of initiating the HPV vaccine series, late (ages 13-26) or never, relative to on-time vaccination (by age 12). NL-Southeast Asian Americans are significantly more likely to never vaccinate and to vaccinate late than NL-White, NL-Black, and Latinx Americans, relative to on-time vaccination. NL-Southeast Asian American boys/men are significantly more likely to never initiate the HPV vaccine than Latinx boys/men, relative to on-time vaccination. NL-Southeast Asian American girls/women are significantly more likely to never vaccinate and vaccinate late than NL-White, NL-Black, and Latinx girls/women, relative to on-time vaccination. There are significant gender differences in uptake among all racial and ethnic groups, except among NL-Southeast and NL-East Asian Americans. Disaggregated data on NL-Southeast Asian Americans helps scholars and public health officials uncover health disparities and improve health interventions. Targeted HPV vaccine promotion and services for this population are needed to mitigate current and future health disparities and promote health equity.
The participants in the controlled intervention group are assigned to have an attention routine in a relaxed position. They are required to sit comfortably and relax in a quiet area to put on their MUSE headband, set it up, and use the same practices on MUSE app but they will mute all the neurofeedback sounds and instructions. Instead, on their smartphone the participants will check their emails, the news, or their preferred social media platform for 10 minutes. Once the session is over, the participants receive the graphical feedback of their brain activities. The feedback includes a timeline indicating their brain states (active, or relaxed) during the 10-minute session.
Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence of FBR poses a heavy burden on both the medical and socioeconomic systems. This review seeks to elucidate the protein "fingerprint" of implant materials, which is generated by the physiochemical properties of the implant materials themselves. In this review, the activity of macrophages, the formation of foreign body giant cells (FBGCs), and the development of fibrosis capsules in the context of FBR are introduced. Additionally, the relationship between various implant materials and FBR is elucidated in detail, as is an overview of the existing approaches and technologies employed to alleviate FBR. Finally, the significance of implant components (metallic materials and non-metallic materials), surface CHEMISTRY (charge and wettability), and physical characteristics (topography, roughness, and stiffness) in establishing the protein "fingerprint" of implant materials is also well documented. In conclusion, this review aims to emphasize the importance of FBR on implant materials and provides the current perspectives and approaches in developing implant materials with anti-FBR properties.
Small molecules that can restore the action of legacy antibiotics toward drug-resistant bacteria represent an area of ongoing research interest. We have previously reported indole-3-glyoxylamido and indole-3-acetamido-polyamine conjugates that exhibit intrinsic activity toward bacterial and fungal species, and the ability to enhance the action of doxycycline toward the Gram-negative bacteria Pseudomonas aeruginosa; however, these desirable activities were commonly associated with unfavorable cytotoxicity and/or red blood cell hemolytic properties. In this paper, we report the synthesis and biological investigation of a new class of α,ω-di(indole-3-carboxamido)polyamine derivatives, leading to the identification of several analogues that exhibit antimicrobial- and antibiotic-potentiating activities without detectable cytotoxic or hemolytic properties. 5-Bromo-substituted indole analogues 3 and 12-18 were generally more broad-spectrum in their activity than others in the set, with 13b (polyamine PA-3-6-3) being particularly notable for its anti-Staphylococcus aureus, Acinetobacter baumannii, and Cryptococcus neoformans activities (MIC ≤ 0.28 µM). The same analogue also restored the action of doxycycline toward P. aeruginosa with a 21-fold enhancement, while the corresponding 5-bromo-indole-3-carboxamide-PA3-7-3 analogue was able to enhance the action of both doxycycline and erythromycin toward P. aeruginosa and Escherichia coli, respectively. The analogue 13b was capable of disrupting the bacterial membrane of both S. aureus and methicillin-resistant S. aureus (MRSA) and the outer membrane of P. aeruginosa, suggesting that membrane perturbation could be a mechanism of action of both intrinsic antimicrobial activities and antibiotic potentiation.
The invention discloses a biological type drug membrane and a preparation method thereof. The main components of the biological type drug membrane are leaven and additives including film-forming material, plasticizer, aromatic and so on. The making process flow of the drug membrane is as follows: firstly the slurry of the film-forming material is prepared; inactivated leaven and the additives are added and evenly mixed, and then the processes of deaeration, coating, drying, deciduation and packing are carried out. Compared with the prior art, by adopting the leaven as the main component, the drug membrane not only plays a role of protecting a wound surface but also improves the nutrient metabolism of oral mucosa, protects various cell injuries and enhances body immunity. In addition, the drug membrane has the characteristics of small volume and light weight and is also more convenient for being easy to be packed, stored, transported, carried over and used. The biotype-drug membrane is mainly used for treating various congestion, erosion and ulcerous lesion. And the biological type drug membrane has good effect on treating recurring Aphthous ulcer and oral lichen planus (congestive and erosive type).
Belonging to the field of fine chemicals, the invention relates to a natural plant shampoo with natural plants as the main raw materials. The main ingredients include: saponin and sapindus. At the same time, in order to strengthen the hair cleaning and hair care effects, ginseng, Chinese angelica, cypress leaf, Fallopia multiflora, ginger and the like are adopted as the auxiliary raw materials. The main and auxiliary raw materials are added into water in certain proportion to prepare an extracted solution, i.e. the natural plant shampoo, or the following accessories, i.e. a hard water agent, a thickening agent and an anti-dangdruff agent are added into the extracted solution, and then the mixture is applied. The main raw materials saponin and sapindus can be used in collaboration, or can be used separately, and the auxiliary raw materials can be combined arbitrarily according to different performance requirements. Obviously, the raw materials can form a variety of formula combinations that all belong to the category of the invention. The natural plant shampoo provided by the invention can replace petrochemical ingredient shampoos, is natural and environment-friendly, has no pollution to the environment, and is harmless to the human body.
Participants will receive an e-pamphlet on physical exercise developed by The Arthritis Society, and will be invited to complete a yoga training program. The yoga training program is a structured low-intensity Vishwas-Raj. Participants will be asked to complete three individual 1-hour sessions per week for 12 consecutive weeks by watching a previously filmed session led by a qualified yoga instructor and posted on Facebook. They will also take part in a 1-hour virtual group session per week using a video-conferencing platform. Participants will also participate in weekly e-consultations with a research coordinator and discussions on Facebook with other participants.