anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The emergence of carbapenem-resistant Escherichia coli strains poses a considerable challenge to global public health, and little is known about carbapenemase-producing E. coli strains in Tianjin, China. This study aimed to investigate the risk factors for infections with carbapenem-resistant E. coli (CREC) strains. This retrospective case-control study was conducted at a tertiary teaching hospital. A total of 134 CREC clinical isolates were collected from the General Hospital of Tianjin Medical University between 2013 and 2020. The control group was selected at a ratio of 1:1 from patients with nosocomial carbapenem-susceptible E. coli infection. Risk factors for nosocomial CREC infection and clinical outcomes were analyzed using univariate and multivariate analyses. Multivariate analysis revealed that cephalosporin exposure (odd ratio OR = 2.01), carbapenem exposure (OR = 1.96), glucocorticoid exposure (OR = 32.45), and surgical history (OR = 3.26) were independent risk factors for CREC infection. The in-hospital mortality rate in the CREC group was 29.1%, and age >65 years (OR = 3.19), carbapenem exposure (OR = 3.54), and central venous catheter insertion (OR = 4.19) were independent risk factors for in-hospital mortality in patients with CREC infections. Several factors were identified in the development of nosocomial CREC infections. The CREC isolates were resistant to most antibiotics. Reducing CREC mortality requires a comprehensive consideration of appropriate antibiotic use, underlying diseases, and invasive procedures.IMPORTANCEEscherichia coli is an opportunistic pathogen that causes severe hospital-acquired infections. The spread of carbapenem-resistant E. coli is a global threat to public health, and only a few antibiotics are effective against these infections. Consequently, these infections are usually associated with poor prognosis and high mortality. Therefore, understanding the risk factors associated with the causes and outcomes of these infections is crucial to reduce their incidence and initiate appropriate therapies. In our study, several factors were found to be involved in nosocomial carbapenem-resistant E. coli (CREC) infections, and CREC isolates were resistant to most antibiotics. Reducing CREC mortality needs a comprehensive consideration of whether antibiotics are used appropriately, underlying diseases, and invasive interventions. These findings provide valuable evidence for the development of anti-infective therapy, infection prevention, and control of CREC-positive infections.
Pathologists use digital pathology for diagnosis by using full-section images (WSI). Interpretable AI (xai) is a new approach to AI that can reveal the root cause of its results. It can thus be seen that xAI can improve the safety, reliability, and interpretability of machine learning for critical tasks such as pathological diagnosis. HistoMapr provides the pathologist with intelligent xAI guidance to improve the efficiency and accuracy of pathological diagnosis. HistoMapr may preview WSI for an entire pathological case, identify critical diagnostic regions of interest (ROIs), determine one or more conditions associated with each ROI, temporarily mark each ROI with the identified conditions, and may shunt them. The ROI is presented to the pathologist in an interactive, interpretable manner for rapid interpretation. The pathologist can control and can go through "why "interface access xAI analysis. HistoMapr can track the pathologist's decisions and compile pathology reports using suggested, standardized terms.
Affective symptoms (e.g., depression, anxiety, shame) are a potent risk factor for binge eating. However, less is known on the role of loneliness as a moderator of affective symptoms and binge eating. This objective of the current study was to investigate main effects and interactions of affective symptoms and loneliness in relation to binge eating in college women. A sample of 556 undergraduate women completed self-report questionnaires of affective symptoms, loneliness, and binge eating. Results revealed significant interactions between each affective symptom variable and loneliness in relation to binge eating, such that loneliness strengthened the positive association of affective symptoms and greater binge eating. The findings of this study demonstrate an important role of loneliness to binge eating among college women, especially those with underlying affective vulnerabilities. More theoretical and treatment-oriented work on the role of loneliness in binge eating is needed to understand mechanisms and interventions/preventions.
FIELD: cardiology. SUBSTANCE: invention, in particular, relates to preventing recurrent cardiac infarction in persons not suffering from hypertonic disease. On 16-18th day after the beginning of infarction, patient receives 12,5 mg Atenolol in the morning and 2.5 mg Enap in the evening. In the second week, dose of Atenolol is increased to 12.5 mg in the morning with the evening dose of Enap as before. In the third week, Atenolol and Enap are continued to be administered both in the morning and in the evening in doses 12.5 mg and 2.5 mg, respectively. If hypotonia is not present, in the 4-5th week, morning and evening doses of Atenolol are increased to 25 mg. Such therapy is continued for 2 years combined with simultaneous administration of single 125 mg doses of aspirin and prolonged nitrates in conventional dosages. EFFECT: enhanced efficiency of cardiac infarction prevention. 5 cl, 2 tbl, 4 ex
PURPOSE:To produce the titled polypeptide useful for the detection of anti- ATLA antibody and the prevention of the ATLV infection, in large quantities at a low cost, by culturing a microorganism having a recombinant plasmid integrated with a DNA fraction coding the env gene of ATLV. CONSTITUTION:The DNA coding the surface antigen peptide gene (env gene) of adult T-cell leukemia virus (ATLV), e.g. the DNA from PATK100, is integrated in a vector DNA (e.g. PAM82) by the method of recombinant DNA to obtain a recombinant plasmid (e.g. PATYE307). The recombinant plasmid is integrated in a microbial cell (preferably yeast belonging to Saccharomyces cerevisiae by transformation, and the obtained transformed strain is cultured in a medium to produce and accumulate the ATLV antigen polypeptide coded with env gene in the cultured product. The objective antigen polypeptide is separated from the cultured product.
Patients receive azacitidine and GO as in Arm B. Patients also receive avelumab IV over 60 minutes on days 1 and 14. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
PURPOSE: To obtain a medicinal composition consisting of a combination of a ranitidine compound (histamine H2 antagonistic agent), alginic acid compound (therapeutic agent for gastrointestinal disorders) and (bi)carbonate (carbon dioxide source), and improved in the therapeutic effect on gastrointestinal disorders. CONSTITUTION: This medicinal composition is obtained by formulating (A) ranitidine or its physiologically permissible salt, esp. ranitidine hydrochloride, (B) alginic acid or its physiologically permissible salt, esp. alginic acid, sodium or magnesium salt thereof, and (C) a carbonate or bicarbonate, esp. NaHCO3 , KHCO3 , MgCO3 or CaCO3 , as the essential ingredients. The respective ingredients play the following roles: the ingredient A forms suspended matter on the upper part of gastric contents so as to protect the esophageal mucosa from the backflow of the gastric contents, the ingredient B reduces the volume and acidity of gastric juice (this is effective, in combination with the action of the ingredient A, for symptom mitigation and cure promotion), and the ingredient C controls the density of the suspended matter and renders its mechanical strength optimum.  The above three effects interact with one another, thus improving the therapeutic effect of this medicinal composition on gastrointestinal disorders.
<P>PROBLEM TO BE SOLVED: To obtain a new axonal regenerating agent for central nervous system cells comprising β-cryptoxanthin having lower toxicity and a high activity at a lower concentration as an active ingredient.  <P>SOLUTION: The axonal regenerating agent for the central nervous system cells is characterized by comprising the β-cryptoxanthin as the active ingredient. An antidement agent is characterized by comprising the β-cryptoxanthin as the active ingredient and has inhibitory actions on apoptosis of the central nervous system cells. A functional food product is characterized in that a prescribed amount of the β-cryptoxanthin is formulated as the active ingredient to prepare the functional food product. Furthermore, the functional food product has the inhibitory actions on the apoptosis of the central nervous system cells. The β-cryptoxanthin has the excellent axonal regenerating actions on the nervous system cells, especially matured central nervous system cells. A drug comprising the compound as the active ingredient is useful as a therapeutic agent, or the like, for neurodegenerative diseases including the antidement agent.  <P>COPYRIGHT: (C)2004,JPO
The invention provides Chinese olive restlessness relieving and alcohol effect dispelling tea and a production method thereof. Chinese olive, suffrutescent securinega twigs, ulmus macrocarpa hance, trapa incisa var. sieb., madder, sunflowers, semen celosiae, radix paeoniae rubra, round cardamom fruit, radix cyathulae, cynanchum mooreanum hemsl. and tribulus terrestris serve as raw materials. The method mainly includes the following steps of firstly, preparing materials according to the formula, and washing the materials; secondly, conducting drying and sterilizing; thirdly, selecting the dried raw materials according to the ratio; fourthly, grinding, mixing and frying the raw materials; fifthly, soaking the raw materials, conducting decoction multiple times, and extracting filtered fluid multiple times; sixthly, mixing filtered fluid, concentrating filtered fluid to obtain concentrated fluid, and drying concentrated fluid to obtain mixed powder; seventhly, conducting bagging and disinfecting to obtain the finished product. The Chinese olive restlessness relieving and alcohol effect dispelling tea has the functions of relieving restlessness, dispelling alcohol effects, tonifying spleens, invigorating stomachs and clearing away heat and toxic materials after being used for a long time.
INTRODUCTION: The neutrophil-percentage-to-albumin ratio (NPAR), a novel inflammatory biomarker, has been used to predict the prognosis of patients with cancer and cardiovascular disease. However, the relationship between NPAR and chronic kidney disease (CKD) remains unknown. The purpose of this study was to investigate the possible association between NPAR and CKD.
METHODS: The cross-sectional study included participants with complete information on NPAR, serum creatinine (Scr), or urinary albumin-to-creatinine ratio (UACR) from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). CKD was defined as the presence of either low estimated glomerular filtration rate (eGFR) or albuminuria. Univariate and multivariate logistic regression and restricted cubic spline regression were used to assess the linear and nonlinear associations between NPAR and renal function. Subgroup and interactive analyses were performed to explore potential interactive effects of covariates. Missing values were imputed using random forest.
RESULTS: A total of 25,236 participants were enrolled in the study, of whom 4518 (17.9%) were diagnosed with CKD. After adjustment for covariates, the odds ratios (ORs) for prevalent CKD were 1.19 (95% CI = 1.07-1.31, p <0.05) for the Q2 group, 1.53 (95% CI = 1.39-1.69, p < 0.001) for the Q3 group, and 2.78 (95% CI = 2.53-3.05, p < 0.001) for the Q4 group. There was a significant interaction between age and diabetes mellitus on the association between NPAR and CKD (both p for interaction < 0.05). And there was a non-linear association between NPAR levels and CKD in the whole population (p for non-linear < 0.001). All sensitivity analyses supported the positive association between NPAR and CKD.
CONCLUSIONS: NPAR was positively correlated with increased risk of CKD. The NPAR may serve as an available and cost-effective tool for identifying and intervening the individuals at risk of CKD.
Participants will complete 8-week course (75-minute, weekly yoga classes) delivered online via videoconferencing software. Participants will complete patient-reported outcomes at baseline (prior to class 1) and post-intervention (after class 8), as well as post-intervention measures of feasibility/acceptability.
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see CITATIONS) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia. The goal of this project is to assess the limits and mechanisms of neural plasticity in amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in adults with amblyopia. Research participants will be asked to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.
PURPOSE: An anionic drug delivery system containing cationic lipid and a method for preparing the same are provided to enhance anionic drug stability in the body and improve treatment efficiency. CONSTITUTION: A drug delivery system for delivering anionic drugs contains a cationic lipid of chemical formula 1. The anionic drug is an antisense oligonucleotide, aptamer, or siRNA. A method for preparing the drug delivery system comprises a step of reacting oligoalkylene amine of chemical formula 2 with acryl halide of fatty acid of chemical formula 3 and acyl halide of fatty acid of chemical formula 4. A pharmaceutical composition contains the anionic drug and cationic lipid of chemical formula 1. The composition is prepared in the form of a liposome, micelle, emulsion, or nanoparticle. A pharmaceutical composition with a micelle formulation contains the anionic drug, cationic lipid, and amphiphilic block copolymers.
MES is a web-based, mobile asthma management intervention delivered to participants' personal mobile devices. There are 4 sessions, completed over 10 weeks, with each session taking approximately 15-20 minutes. During Session 1, participants will identify asthma-related problems they may encounter and will receive asthma information and motivation. Between Session 1 and Session 2, participants will be asked to complete an electronic daily diary for 7 days. Session 2 allows participants to select up to 2 goals to address. Session 3 occurs over the course of 4 weeks and provides tailored messages based on problem and goal selection. The final session (Session 4), asks participants for feedback on how well they feel they accomplished their goal. Additionally, participants will be asked to track their daily and weekly step totals as well their total minutes of moderate to vigorous physical activity using a wearable activity tracker provided by the study.
The study is a prospective 2 year multimodal follow-up study of initially antipsychotic-naïve first-episode psychotic patients involving a standardized intervention with monotherapy with aripiprazole during the first 6 weeks. Patients and matched healthy controls will be examined at baseline and after 6 weeks, 6 months and 2 years.

Levels of glutamate and gamma-aminobutyric acid (GABA) are measured by proton magnetic resonance spectroscopy (1H-MRS) in the anterior cingulate cortex ACC and thalamus. Presynaptic Dopamine level is measured with Positron Emission Tomography Computed Tomography (PET/CT)-scanning using 3,4-dihydroxy-6-\[18F\]fluoro-L-phenylalanine (18F-DOPA). Disturbances of the reward system is measured with functional magnetic resonance imaging (fMRI) . Regional cerebral blood flow and activity in the same regions are measured with Pseudo-continuous arterial spin labelling (pCASL). The default mode network, functional and structural connectivity in the associated macro circuits are measured with resting state fMRI, EEG, and diffusion tensor imaging. Structural brain changes (in grey and white matter) are measured with MRI. Cognitive functions are measured with a neuropsychological test battery, and early information processing with event related EEG and electromyography (EMG) (psychophysiological examinations). Further patients psychopathology will be rated.
Participants will receive supervised, moderate intensity (50-75% maximum heart rate) aerobic exercise sessions, 3 times per week for 50 minutes in duration. After the exercise portion of each session, participants assigned to the HEAT condition will be asked to sit quietly on the bench in the steam-room within their same-sex locker room for no more than 20 minutes. They will start at 11 minutes to get acclimated to the mild heat stress, and gradually work up to 20 minutes. A trained research staff member will be stationed outside the room.
The overall goals of this study are to evaluate patients with acute respiratory failure from the time they are orally intubated in the ICU to: 1) investigate tongue weakness and other pathophysiological aspects of dysphagia, and 2) evaluate, in a Phase II clinical trial, a novel, multimodal, sensorimotor intervention conducted during intubation to reduce or prevent dysphagia after extubation. Patients who are expected to be intubated with mechanical ventilation for \>96 hours will be consecutively enrolled shortly after intubation. Laryngeal function, tongue strength, swallowing pathophysiology, and breathing-swallowing coordination will be evaluated with valid and reliable standardized measures. While orally intubated, patients in the treatment group will receive a novel, early, sensorimotor intervention for 60-minutes daily, 5 times per week, targeting improved swallowing physiology and kinematics to reduce aspiration and dysphagia. These daily sessions will continue until the completion of a modified barium swallow study conducted within approximately 2 days after extubation, and thereafter standard clinical care will resume. Patients in the control group will receive standard clinical care during intubation and throughout their hospital stay. All patients will be followed to hospital discharge to determine the pathophysiological and clinical impact of the proposed intervention. Knowledge from this study will provide important data for this novel intervention and provide a critical foundation for understanding the physiological mechanisms of dysphagia and aspiration after intubation in patients with acute respiratory failure. With success, this investigation will help shift clinical practice patterns to consider early intervention with the goal of reducing the frequency and severity of swallowing impairment leading to aspiration and additional medical complications.
Polysaccharides can benefit the liver via modulation of the gut microbiota, but the exact mechanism is still unclear. This study demonstrated that the effect of Scytosiphon lomentaria fucoidan (SLF) on alcohol-induced liver injury can be closely related to the level of Parabacteroides distasonis (Pd) via in vivo and in vitro models. Further mice experiment showed that Pd alleviated liver injury and inflammation by suppressing the NF-κB/MAPK pathways and activating Nrf2 pathway. The underlying mechanism can be closely associated with modulation of the gut microbiota, particularly an increase in microbiota diversity and beneficial bacteria and a reduction in Proteobacteria. Targeted metabolomics indicated that Pd ameliorated alcohol-induced dysbiosis of microbiota metabolites profile, primarily affecting amino acid metabolism. Moreover, Pd reduced the level of total bile acids (BAs) and improved BAs profile, affecting the expression levels of BA-associated genes in the liver and ileum involved in BA synthesis, transport, and reabsorption. This study suggests that SLF can benefit alcohol-induced liver injury via P. distasonis-mediated regulation of the gut-liver axis.
Chronic obstructive pulmonary disease (COPD) is a common lung disease that negatively affects health-related quality of life (QoL). Utility values, which measure QoL by weighting health states with societal preferences, are required for the cost-utility models that drive economic evaluations and policy decisions. Moayeri et al. published a systematic review and meta-analysis of utilities (EQ-5D) in COPD in June 2016. The current study investigated changes in mean utilities in more recent studies thereafter, exploring heterogeneity in utilities across diverse clinical and study characteristics. Systematic searches of databases, such as MEDLINE and Embase were undertaken from 1 July 2015 until 20 May 2024. A random-effects meta-analysis of utilities (EQ-5D) was performed which addressed inter-study heterogeneity and subgroup analyses. The pooled general mean (95% CI) utility value was 0.761 (0.726-0.795) from 43 studies, whereas Moayeri et al. reported 0.673 (0.653-0.693) from 32 studies. This improvement in mean utilities could be due to increased awareness, early detection, and better medical interventions over the past decade, but demonstrates that a general utility value should be approached with caution given significant heterogeneity. Four meta-regressions were performed on each subgroup: region, method of elicitation, reported comorbidities, and disease stage; of which, method of elicitation, disease stage, and region were found to be significant moderators of utilities. It is, therefore, important to use meta-analysed utilities for cost-utility analyses that reflect the context and patient population of the model. Moreover, these results provide additional evidence for the precision and sensitivity of EQ-5D-5L over EQ-5D-3L.
An antibiotic resin adsorbate comprises the reaction product of bacitracin and a particulate cross-linked cation-exchange resin consisting of a sulphonated styrene/divinyl benzene copolymer, or a monovalent cation salt thereof, e.g. a sodium, potassium or ammonium salt.  In examples bacitracin sulphate is reacted with a sodium salt of the resin.  The adsorbate finds application as a feed supplement in swine and poultry feeds.ALSO:In a process for the isolation and purification of bacitracin from aqueous solution, the pH of the solution is adjusted to from 3 to 7 (e.g. with sulphuric acid) and the solution is then contacted with a salt of a sulphonated copolymer of styrene with divinyl benzene, to cause adsorption of the bacitracin on the copolymer.  Elution of the bacitracin from the adsorbate obtained, may be effected with an aqueous base having a pH of 7.5 to 8.5, e.g. with 2% sodium carbonate solution.  In examples bacitracin sulphate is contacted with a sodium salt of the sulphonated copolymer.ALSO:An antibiotic feed supplement comprises a feed acceptable diluent together with an adsorbate of bacitracin on a salt of a sulphonated styrene/divinyl benzene copolymer, said adsorbate being present in from 5 to 50 grams of bacitracin activity per pound of supplement.  The adsorbates may be used in conjunction with other antibiotic or therapeutic agents such as penicillin, oxytetracycline, chlortetracyline, tetracycline, phenyl arsonic acid or sulphaquinoxaline and may be blended with grains, fish meal, bone meal, soybean meal, limestone, vitamins and amino acid ingredients. In examples specified feed ingredients are corn, soybean meal, corn gluten meal, alfalfa meal, animal fat, fish meal, corn solubles, whey, brewers' yeast, iodized salt, calcium carbonate, calcium phosphate, Delamix, methionine, Vitamins A, B12 and D3, riboflavin, calcium pantothenate, niacin, choline chloride, diphenylphenylenediamine, skim milk, sucrose, mineral mix and saccharin.  The feed supplements are of particular use for swine and poultry feeds.