anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine; clinical stomatology; production of tooth-filling materials. SUBSTANCE: proposed tooth-filling composition traditionally contains calcium oxide hydrate. Inventive novelty of composition resides in fact that it further contains feedstock used for making aluminofluorosilicate glass; 2,3-bis-(hydroxymethyl) quinoxaline 1,4-di-N-oxide and 40%-aqueous polyacrylic acid solution, said components being taken in following weight ratio, wt. %: Calcium oxide hydrate 3.10-4.60 Aluminofluorosilicate glass feedstock 94.20-96-10 2,3-bis-(hydroxymethyl) quinoxaline 1,4-di-N-oxide 0.10-0.70 Polyacrylic acid in form of 40%-aqueous solution balance. In order to ensure complete reaction between aluminofluorosilicate glass feedstock and polyacrylic acid solution without formation of residual products and to thereby obtain material harmless for patient's teeth, it is recommended to use aluminofluorosilicate glass containing quartz sand, aluminium hydroxide, aluminium orthophosphate, synthetic cryolite, calcium fluoride, and aluminium fluoride, said components being taken in following weight ratio, wt.%: Quartz 16.40-16.80 Aluminium hydroxide 29.30-29.70 Aluminium orthophosphate 12.90-13.30 Synthetic cryolite 16.00-16.40 Calcium fluoride 12.30-12.70 Aluminium fluoride 11.90-12.30. EFFECT: proposed composition possesses all merits of conventional tooth-filling compositions and, in addition, produces bactericidal effect and has self-hardening base, thereby providing good sealing for filled teeth, reducing occurrence rate of recidives and carious complications. 2 cl
In the last decades, neurofeedback has been established as a promising scientific tool. Learning voluntary control over their own brain activity allows for establishing causal links between brain activity and mental functions. However, patients participants differ in their ability to learn control over their own brain activity with neurofeedback. It is thus crucial to understand why some participants are more successful in regulating their own brain activity than others. The objective of the present study is thus to identify predictors for successful learning self-regulation with real-time fMRI neurofeedback. To achieve this goal, we will evaluate the introspection ability of healthy participants using standardized psychological questionnaires and tasks. These scores will then be correlated with how well they learned self-regulation skills using established real-time fMRI neurofeedback protocols.
The present invention relates to the preparation and the application of a granule adjuvant for suppressing bacteria, and belongs to the technical field of biologic vaccines. One of bacterial suspension liquids in long bifidus bacilli and subtilis bacilli APCC9372 is selected; dry bacilus bodies are prepared after the bacterial suspension liquid is washed, centrifuged, thrown in supernatant liquid, dried, etc.; then, the bacilus bodies are washed by 5% glacial acetic acid, centrifuged and thrown in supernatant liquid, and is suspended by 1% glacial acetic acid, centrifuged and thrown in supernatant liquid again; and the process is repeated for one time. The bacilus bodies are suspended again by 1% glacial acetic acid, incubated at 100 DEG C, sterilized, centrifuged and thrown in supernatant liquid, and then is washed with 0.9% NaCl and distilled water, centrifuged and thrown in supernatant liquid. The granule adjuvant for suppressing bacteria is prepared after the bacilus bodies are frozen and dried. The method is used for preparing weak antigen vaccines, such as HBV, HIV, HCMV, etc., and is also used for making hepatitis treatment vaccines and preventive vaccines, or is used as a candidate medicine for resisting tumors. The granule adjuvant for suppressing bacteria has the function for strongly stimulating the immune performance of body cells.
The present invention discloses an antivirotic medicine composition, and the preparation process and the purpose thereof. According to the weight percentage, the antivirotic medicine composition comprises 1 percent to 9 percent of honeysuckle flower extract, 2 percent to 10 percent of coptis root extract, 3 percent to 15 percent of hypericum perforatum extract and supplementary materials. The present invention has the preparation process that the honeysuckle flower extract, the coptis root extract and the hypericum perforatum extract are respectively crashed and sieved. The honeysuckle flower extract, the coptis root extract and the hypericum perforatum extract after sieved are weighed to take according to the weight percentage, and the rest is the supplementary materials. The antivirotic medicine composition is made up after mixing the medicine materials. The antivirotic medicine composition of the present invention is applied for the preparation of medicines preventing and curing the familiar virosis of poultries, the preventing and curing rate of the virosis can reach more than 90 percent, wherein the curing rate of infectious bursal disease of chickens reaches up to 98.6 percent. The present invention has little toxicity, low cost and convenient use, and can be directly added in animal feed and drinking water.
Within Latin America, there is a significant lack of data about the medical management and self-care for patients with non-communicable diseases (NCDs), such as diabetes and hypertension. In an effort to improve availability of such data in the Latin American region, the World Health Organization (WHO) created and tailored a survey tool that has been used in various countries throughout Central and South America. Our own research team has extensive experience surveying clinic-based populations in Latin America regarding their chronic disease burden and the potential effectiveness of novel approaches to self-care support via mobile phones. The objective of the planned project is to gather baseline surveillance data for non-communicable diseases in urban and peri-urban Bolivian communities, using the WHO instrument as a foundation with modifications to reflect local public health priorities and the goal of developing mobile health services that improve self-management support.

This project will be conducted by investigators and students of the University of Michigan Schools of Medicine, Public Health, and Information, in partnership with the Catholic University of Bolivia, San Pablo (UCB-San Pablo). The over-arching aim is to conduct a longitudinal survey of health indicators in a variety of primary and ambulatory care sites within clinics associated with Universidad Católica Boliviana, including SEDES La Paz and Universidad Mayor San Andres, in La Paz and El Alto, Bolivia. The survey is based on: a) the World Health Organizations' Division of Disease Prevention and Control's Program on Non-Communicable Diseases' (NCD) Surveillance Toolkit: Risk Factors for Non-Communicable Diseases, with the addition of b) the 8 Item Patient Health Questionnaire (PHQ-8) to screen for Depression, c) the Alcohol Use Disorders Identification Test (AUDIT), d) the Patient Assessment of Chronic Illness Care (PACIC) Questionnaire, e) questions developed by our research team regarding the feasibility and desirability of mobile health monitoring and self-care support and f) 8 item Morisky Medication use questions. By using validated survey instruments, the investigators will be able to compare health indicators across countries and provide the participating Bolivian government agencies and universities information crucial to understanding the factors contributing to the development and maintenance of NCD services in Bolivia. Specifically, this study will provide baseline data, which does not exist to date, identifying the prevalent risk factors for NCDs and the barriers to those patients' care. More generally, the investigators will gain invaluable experience regarding the feasibility of enrolling large representative samples in various outpatient sites for use in subsequent observational studies of NCD management and in randomized trials.
INTRODUCTION: Artificial intelligence and large language models (LLMs) have emerged as potentially disruptive technologies in healthcare. In this study GPT-3.5, an accessible LLM, was assessed for its accuracy and reliability in performing guideline-based evaluation of neuraxial bleeding risk in hypothetical patients on anticoagulation medication. The study also explored the impact of structured prompt guidance on the LLM's performance.
METHODS: A dataset of 10 hypothetical patient stems and 26 anticoagulation profiles (260 unique combinations) was developed based on American Society of Regional Anesthesia and Pain Medicine guidelines. Five prompts were created for the LLM, ranging from minimal guidance to explicit instructions. The model's responses were compared with a "truth table" based on the guidelines. Performance metrics, including accuracy and area under the receiver operating curve (AUC), were used.
RESULTS: Baseline performance of GPT-3.5 was slightly above chance. With detailed prompts and explicit guidelines, performance improved significantly (AUC 0.70, 95% CI (0.64 to 0.77)). Performance varied among medication classes.
DISCUSSION: LLMs show potential for assisting in clinical decision making but rely on accurate and relevant prompts. Integration of LLMs should consider safety and privacy concerns. Further research is needed to optimize LLM performance and address complex scenarios. The tested LLM demonstrates potential in assessing neuraxial bleeding risk but relies on precise prompts. LLM integration should be approached cautiously, considering limitations. Future research should focus on optimization and understanding LLM capabilities and limitations in healthcare.
Participants the Enhanced Implementation (SI) model complete the 6 week structured Walk with Ease group exercise program designed to build capacity and function in older adults. Sessions are held 3 days a week for an hour each session. Each session includes a 10 minute warmup including strength/flexibility exercises, a 30 minute bout of walking and a 10 minute cool-down including strength/flexibility exercises. Participants complete personalized exercises prescribed by a licensed Physical Therapist to help reduce potential risks of falling.
Benign prostatic hyperplasia (BPH), a change in the size composition, and function of prostate gland, leads to obstruction of the bladder and urethra in middle-aged and elderly males. Clinically α 1A-adrenoceptor antagonists and 5 alpha reductase inhibitors are applied to the treatment of BPH. KMUP-1 is a synthetic xanthine-based derivative and has been demonstrated to raise cyclic nucleotides, to inhibit phosphodiesterases (PDEs), and to activate potassium channels, resulting in relaxations of aortic, corporeal carvenosa, and tracheal smooth muscles. In this study we found that KMUP-1 has high selective α 1A-adrenoceptor binding property in the prostae. On the other hand, in isolated male rat prostate, preconstricted with phenylephrine(10 μM), KMUP-1 (0.001 - 100 μM) caused a concentration-dependent relaxation. Moreover, the relaxation of KMUP-1 was attenuated by pretreatments with a soluble guanylyl cyclase (sGC) inhibitor ODQ, a PKG inhibitor Rp-8-CPT-cGMPs, a K+ channel blocker TEA, a KATP channel blocker glibenclamide, a voltage-dependent K+ channel blocker 4-AP and Ca2+ -dependent K+ channel blockers apamin and charybdotoxin ChTX in the rat isolated prostate. In conclusion, KMUP-1 inhibit α 1A-adrenoceptor and induce K+channel opening to enhance prostate relaxation.
Cognitive impairment in Parkinson's disease (PD) is associated with changes in the brain anatomical structures. The objective of this study, is to identify the atrophy patterns based on the severity of cognitive decline and evaluate the disease progression. In this study, gray matter alterations are analysed in 135 PD subjects under 3 cognitive domains (91 Cognitively normal PD (NC-PD), 25 PD with Mild Cognitive Impairment (PD-MCI) and 19 PD with Dementia (PD-D)) by comparing them with 58 Healthy Control (HC) subjects. Voxel Based Morphometry (VBM) is used to segment the gray matter regions in magnetic resonance images and analyse the atrophy patterns statistically. Significant patterns of gray matter variations observed in the middle temporal and medial frontal region differentiate between HC and PD subject groups based on the severity of cognitive decline. Abnormalities in gray matter is substantiated through radiomic features extracted from the significant gray matter clusters. Significant radiomic features of the clusters are able to differentiate between the HC and PD-D subjects with an accuracy of 81.82%. Higher atrophy levels identified in PD-D subjects compared to NC-PD and PD-MCI group enables early diagnosis and treatment procedures. The combined and comprehensive analysis of gray matter alterations through VBM and radiomic features gives better assessment of cognitive impairment in PD.
Enrollment for group 2 was closed. Renal transplant recipients with functioning allografts (not on dialysis) who had not received immunosuppressive medications for at least 1 year (or at investigator's discretion) but who had moderately impaired or gradually deteriorating renal function, defined as creatinine clearance (CrCl) \< 40 mL/min and/or creatinine \> 50% above baseline value, and thus did not qualify for group 1.
Pulsatile gonadotropin-releasing hormone (GnRH) release is critical for reproduction. Disruptions to GnRH secretion patterns may contribute to polycystic ovary syndrome (PCOS). Prenatally androgenized (PNA) female mice recapitulate many neuroendocrine abnormalities observed in PCOS patients. PNA and development induce changes in spontaneous GnRH neuron firing rate, response to synaptic input, and the afterhyperpolarization potential of the action potential. We hypothesized potassium currents are altered by PNA treatment and/or development. Whole-cell patch-clamp recordings were made of transient and residual potassium currents of GnRH neurons in brain slices from 3-week-old and adult control and PNA females. At 3 weeks of age, PNA treatment increased transient current density versus controls. Development and PNA altered voltage-dependent activation and inactivation of the transient current. In controls, transient current activation and inactivation were depolarized at 3 weeks of age versus in adulthood. In GnRH neurons from 3-week-old mice, transient current activation and inactivation were more depolarized in control than PNA mice. Development and PNA treatment interacted to shift the time-dependence of inactivation and recovery from inactivation. Notably, in cells from adult PNA females, recovery was prolonged compared to all other groups. Activation of the residual current occurred at more depolarized membrane potentials in 3-week-old than adult controls. PNA depolarized activation of the residual current in adults. These findings demonstrate the properties of GnRH neuron potassium currents change during typical development, potentially contributing to puberty, and further suggest PNA treatment may both alter some typical developmental changes and induce additional modifications, which together may underlie aspects of the PNA phenotype. There was not any clinical trial involved in this work.
Antigenically distinct SARS-CoV-2 variants increase the reinfection risk for vaccinated and previously exposed population due to antibody neutralization escape. COVID-19 severity depends on many variables, including host immune responses, which differ depending on genetic predisposition. To address this, we perform immune profiling of female mice with different genetic backgrounds -transgenic K18-hACE2 and wild-type 129S1- infected with the severe B.1.351, 30 days after exposure to the milder BA.1 or severe H1N1. Prior BA.1 infection protects against B.1.351-induced morbidity in K18-hACE2 but aggravates disease in 129S1. H1N1 protects against B.1.351-induced morbidity only in 129S1. Enhanced severity in B.1.351 re-infected 129S1 is characterized by an increase of IL-10, IL-1β, IL-18 and IFN-γ, while in K18-hACE2 the cytokine profile resembles naïve mice undergoing their first viral infection. Enhanced pathology during 129S1 reinfection cannot be attributed to weaker adaptive immune responses to BA.1. Infection with BA.1 causes long-term differential remodeling and transcriptional changes in the bronchioalveolar CD11c+ compartment. K18-hACE2 CD11c+ cells show a strong antiviral defense expression profile whereas 129S1 CD11c+ cells present a more pro-inflammatory response upon restimulation. In conclusion, BA.1 induces cross-reactive adaptive immune responses in K18-hACE2 and 129S1, but reinfection outcome correlates with differential CD11c+ cells responses in the alveolar space.
To study the changes of lymphocyte subsets in children with acute lymphoblastic leukemia (ALL) at initial diagnosis and compare them with those of healthy children and patients who have achieved complete remission (CR). Furthermore, we aim to analyze the prognostic significance of lymphocyte subsets in these patients. From May 2011 to December 2015, 405 children with ALL were enrolled in this study. Peripheral blood was collected at the time of diagnosis, and lymphocyte subsets were detected by flow cytometry. Then, the percentages of lymphocyte subsets in each group were compared. In addition, survival and prognostic factor analyses were performed to determine the prognostic value of lymphocyte subsets. Lymphocyte subsets in children with ALL were dramatically different from those in healthy children and patients achieving CR. Additionally, lymphocyte subsets were correlated with different minimal residual disease and risk parameters. Furthermore, percentages of CD3+ T cells and CD4+ T cells and the ratio of CD4/CD8 were associated with different clinical outcomes. Multivariate analysis demonstrated the percentage of CD4+ T cell as an independent predictor for clinical prognosis. Lymphocyte subsets in pediatric ALL undergo dramatic changes and were related to prognosis, especially CD4+ T cells.
Enhanced Problem-Solving Training (E-PST) arm. E-PST is a combined treatment that is comprised of brief problem-solving training and compensatory cognitive skills training. Randomized participants were assigned 1:1 to E-PST or HLM.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed 'long COVID' (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC. Understanding these disease pathologies and how they influence each other is key to developing effective therapeutics and diagnostic tests. Given that ME/CFS typically has a longer disease duration compared with LC, with symptoms and pathologies evolving over time, ME/CFS may provide insights into the future progression of LC.
In this project, we propose to conduct an exploratory clinical trial to investigate the effectiveness of this novel imaging device in detecting small lesions and lymph node involvements in the head and neck region, and compare its results to those obtained from a clinical PET/CT scanner. More specifically, we propose to (1) recruit 5 patients who have confirmed head and neck cancer and are scheduled to receive a whole-body PET/CT scan followed by surgical operation to remove the primary tumor and the regional lymph nodes. These patients will be imaged by a state-of-the-art PET/CT scanner using the standard whole-body PET/CT imaging protocol as standard of care for initial staging. On another day, following consent to participate in this research protocol, A patient will undergo images of the head and neck region using the same type scanner with and without our novel PET insert device attached; (2) The images obtained from the PET insert device will be reviewed by experienced nuclear medicine physicians to identify the extent of lymph node involvement. The PET insert images will be compared to the standard clinical PET/CT images. A detailed image obtained for purposes of research, centered at the level of the head and neck, acquired for approximately 3 times the length of time the standard clinical image is obtained for will also be compared to the PET insert image. Images will also be compared to the pathology report of the surgically removed specimen. (3) Estimate the performance of lesion detection for different sizes of tumors using the standard PET/CT scanner as well as the PET insert device.
PURPOSE: A composition containing carbohydrate or derivatives is provided to relieve skin irritation due to dye and to prevent skin inflammation due to dye. CONSTITUTION: A composition for relieving skin irritation due to dye contains carbohydrate or derivatives as an active ingredient. The carbohydrate or derivatives contain one or more selected from the group consisting of monosaccharides, polysaccharides, and oligosaccharides. The monosaccharides are rhamnose, glucose, galatose, fructose, or xylose. The oligosaccharides are lactose, sucrose, or maltose. The polysaccharides are dextran, starch, xylan, inulin, levan, or galactan.
Hydrogen peroxide 1% (Oximen® 3%) (Reig Jofré, S.A., Spain). The concentration was adjusted to those previously indicated by diluting commercial formulas with distilled water minutes before rinsing (5 mL of hydrogen peroxide 3% - Oximen© with 10 mL of distilled water).
Stratum 2 will include patients who have progressive lesions other than VS (including non-vestibular schwannomas, meningiomas, and spinal cord lesions). Participants will receive continuous twice daily dosing of selumentinib. Dosing is based on BSA calculated at the beginning of each course. One course is equivalent to 28 days. Therapy may continue for up to two years (26 courses) in the absence of disease progression or unacceptable toxicity.
DNA methylation, a crucial biochemical process within the human body, fundamentally alters gene expression without modifying the DNA sequence, resulting in stable changes. The changes in DNA methylation are closely related to numerous biological processes including cellular proliferation and differentiation, embryonic development, and the occurrence of immune diseases and tumor. Specifically, abnormal DNA methylation plays a crucial role in the formation, progression, and prognosis of chronic myeloid leukemia (CML). Moreover, DNA methylation offers substantial potential for diagnosing and treating CML. Accordingly, understanding the precise mechanism of DNA methylation, particularly abnormal changes in the methylation of specific genes in CML, can potentially promote the development of novel targeted therapeutic strategies. Such strategies could transform into clinical practice, effectively aiding diagnosis and treatment of CML patients.
The subjects of this study were chronic subjective tinnitus patients and normal controls who were treated with music therapy combined with cognitive behavioral therapy (music-CBT) in the Department of Otolaryngology of Sun Yat-sen Memorial Hospital from December 2016 to March 2024 and who had completed re-examination. The pre- and post-music-CBT data of past patients who met our study conditions were collected for retrospective statistics. The complete sample data included medical history, pure tone audiometry, tinnitus matching, tinnitus questionnaires (Tinnitus Handicap Inventory, Visual Analog Scales, tinnitus Functional Index), sleep quality questionnaire (Pittsburgh Sleep Quality Index), and depression questionnaire (Hamilton Depression Scale -24 items). The resting state electroencephalogram (rs-EEG). Retrospective statistical analysis was conducted to determine the clinical efficacy and influencing factors of music-CBT for chronic subjective tinnitus at 3 months and long term. Finally, the neural mechanism of music-CBT for tinnitus treatment was analyzed based on rs-EEG results.