anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A complex probiotic composition for livestock is provided to replace antibiotics using three strain producing antibacterial materials. CONSTITUTION: A complex probiotic composition for livestock contains: one or more selected from Lactobacillus sp. AP 116 (KACC 91396), culture containing fungus body thereof, fungus body-free culture thereof, and bacteriocin producing the same; one or more selected from Enterococcus faecium CB 712(KACC 91395), culture containing fungus body thereof, fungus body-free culture thereof, and bacteriocin producing the same; and Pediococcus pentosaceus K23-2 (KACC 91397), culture containing fungus body thereof, fungus body-free culture thereof, and bacteriocin producing the same. The Lactobacillus sp. AP 116 (KACC 91396) is derived from digestive organ of porcine. The Enterococcus faecium CB 712(KACC 91395) is derived from digestive organ of canine. The Pediococcus pentosaceus K23-2 (KACC 91397) is derived from Kimchi.
Histologic classification of pathology specimens through machine learning is a nascent field which offers tremendous potential to improve cancer medicine. Its utility has been limited, in part because of differences in tissue preparation and the relative paucity of well-annotated images. We introduce tissue recognition, an unsupervised learning problem analogous to human face recognition, in which the goal is to identify individual tumors using a learned set of histologic features. This feature set is the “tissue fingerprint.” Because only specimen identities are matched to fingerprints, constructing an algorithm for producing them is a self-learning task that does not need image metadata annotations. Here, we provide an algorithm for self-learning tissue fingerprints, that, in conjunction with color normalization, can match hematoxylin and eosin stained tissues to one of 104 patients with 93% accuracy. We applied this identification network's internal representation as a tissue fingerprint for use in predicting the molecular status of an individual tumor (breast cancer clinical estrogen receptor (ER) status). We describe a fingerprint-based classifier that predicts ER status from whole-slides with high accuracy (AUROC=0.90), and is an improvement over traditional transfer learning approaches. The use of tissue fingerprinting for digital pathology as a concise but meaningful histopathologic image representation enables a new range of machine learning algorithms leading to increased information for clinical decision making in patient management.
Intensive Lifestyle Intervention at Ubberup Folk High School for 10-14 weeks. Daily exercise for 1-3hrs. Calorie restriction (\~-700KCal/day). Education within nutrition, exercise and healthy living in general.
Intervention: daily baths with chlorhexidine wipes, oral spray and shampoo. This arm will receive daily bathing with chlorhexidine wipes at 2% (CLORHEXI-WIPES ONE-STEP, G70 Antisepsis, León, México) plus an oral spray application of chlorhexidine chlorhydrate at 0.12%. For scalp washing, a chlorhexidine shampoo at 0.12% concentration will be applied.
Ionisable or polarisable, carrier-free radionuclides may be separated by electrofixation, in a manner that is particularly well adapted to practical requirements, from a low electric conductivity liquid target material in a flow cell (1) fitted with a permanent electrode arrangement (2, 3). For that purpose, the target liquid is separated while the fixing voltage is maintained, then the fixed radionuclide is removed again from the electrode, if required by heating, after switching off or reversing the poles of the field, possibly after an intermediate rinsing. A cylindrical fixing electrode that forms the vessel casing with an axial counter-electrode shaped as capillaries that extend over the whole length of the cylinder and that at the same time supply the liquid medium are particularly appropriate. Field intensities in a range from 10 to 100 V/cm are appropriate. The flow cell may be integrated in the duct that extends from the nuclide generating station to the radiotracer synthesising apparatus, may form parts thereof or may be constituted by the reaction vessel of the synthesising apparatus. The apparatus is specially designed to extract 18F from H¿2?18O.
Traumatic brain injury (TBI) can be defined as an injury caused by an external force, particularly a direct blow to the head or exposure to a shock wave. In addition to the well-known consequences of TBI, including cognitive changes, motor deficits and sensory abnormalities, available evidence suggests that acute and chronic pain is also common after TBI. Obesity and TBI can be considered as public health problems with their increasing prevalence in recent years. Chronic pain adds to the already enormous clinical, psychological, social and economic burden of obesity. Developing mechanisms to prevent the development of pain after TBI has attracted the attention of researchers. Obesity is a preventable and modifiable clinical condition. The extent to which obesity may create adverse conditions after TBI remains unclear.
Aplastic anemia (AA) is a group of clinical syndromes caused by a significant decrease in bone marrow hematopoietic tissue from different etiologies, resulting in hematopoietic failure. Treatment options for patients with aplastic anemia are very limited. By binding to the thrombopoietin (TPO) receptor, thrombopoietin receptor agonists (TPO-RAs) can cause conformational changes in the TPO receptor, activate the JAK2/STATS pathway, and increase megakaryocyte progenitor cells proliferation and platelet production. At present, TPO-RAs including eltrombopag, lusutrombopag, romiplostim, and avatrombopag have been approved by FDA. In a phase II/III, multicenter, open-label study exploring the efficacy and safety of romiplostim, 31 patients with refractory AA were enrolled. The primary endpoint for the proportion of patients who achieved any hematological (platelet, neutrophil, and red blood cell) response at week 27 was 84% \[95% CI 66-95%\]. At week 53, the three-line response rate was 39% (95% CI 22-58%). However, there are no prospective clinical data exploring whether romiplostim combined with ciclosporin (CsA) can further improve efficacy than ciclosporin monotherapy in newly diagnosed NSAA. Since romiplostim and CsA have good safety, if it is proved that the combination of the two drugs is superior to ciclosporin monotherapy, it can quickly improve blood patterns in NSAA, avoid the use of more expensive ATG, and provide some help to reduce the economic burden of AA patients.
PURPOSE:To collect a novel antibiotic showing antibacterial activity against Gram-positive bacteria, and to use it as a remedy or a preventive, by cultivating a new strain belonging to the genus Streptomyces. CONSTITUTION:Strain KA-5905 belonging to the genus Streptomyces is aerobically cultivated by a culture method of common ray fungus. Novel antibiotic KA- 5905 is obtained from the culture solution by a well-known method. This novel antibiotic can be optionally made into its salt. KA-5905 has the following physical and chemical properties. Molecular weight: 220-300, melting point: 66-69 deg.C, specific rotatory power [alpha]D<20>+205 deg. (Cl, methanol), soluble in methanol, acetone, etc., and insoluble in water, hexane, etc.
Colourless, palatable, aqueous solutions of choline salicylate are prepared by forming a solution of choline bicarbonate, adding thereto a small quantity (e.g. 0.001 to 1%) of a sequestering agent, e.g. a salt of ethylene diamine tetraacetic acid and then adding the stoichiometric quantity of salicylic acid.  The preparation may be performed at temperatures between 10 and 40 DEG  C., e.g. at room temperature.  Reference has been directed by the Comptroller to Specification 869,553.
In China, Europe and America, colorectal cancer is one of common malignant tumors. It is very important for treatment of colorectal cancer to enhance the quality of treatment, increase patients' survival rate and improve the life quality. So far, surgical resection is optimal treatment for patients with colorectal cancer. As a result, increasing the quality of surgery and improving the perioperative managements have a great influence on patients received a coloproctectomy. Investigators have spent over ten years studying enhanced recovery after surgery programs for colorectal cancer and have got some successful experience. Investigators found enhanced recovery after surgery can accelerate patients' recovery without increasing complications. This study is the first multi-center study of enhanced recovery after surgery for colorectal cancer in China. During this period, the study is aimed to evaluate the safety of applying enhanced recovery after surgery for colorectal cancer.
BACKGROUND: The impact of acute aortic dissection of the chronically dissected distal aorta is unknown. This study sought to describe the incidence and characteristics of the triple-lumen aortic dissection and its impact on survival.
METHODS: From 2010 to 2021, a query of a single-institution aortic database identified 1149 patients with chronic distal aortic dissection. Thirty-three (2.9%) patients with at least 3 distinct lumens and 2 separate "primary" intimal tears were identified by analysis of contrast-enhanced cross-sectional imaging. Triple-lumen patients were exactly matched with a cohort of double-lumen patients on a 1:1 ratio using 5 preoperative variables, and outcomes between the groups were assessed.
RESULTS: The median age at time of initial dissection in patients with a triple-lumen dissection was 46 years. Initial dissection was a type A in 33% and a type B in 67% of patients. The median time from initial dissection to triple-lumen diagnosis was 4.2 years. On diagnosis of the triple-lumen aorta, 85% of patients required urgent aortic repair for rapid growth (36%), aortic diameter ≥55 mm (30%), malperfusion (6%), intractable pain (6%), and rupture/type A (6%). Thirty-day mortality after triple lumen dissection was 12%.
CONCLUSIONS: Acute-on-chronic distal dissection resulting in a triple-lumen aorta should be classified as a "complicated" type B dissection as these patients typically have large aneurysms and a high incidence of rapid false lumen expansion requiring urgent surgical repair.
Owing to the continuing gap in cancer burden between Indigenous and non-Indigenous peoples, reducing health disparities has drawn worldwide attention. Evidence indicates that the gastric cancer incidence and mortality rates in Indigenous peoples are much higher than those of non-Indigenous counterparts living in the same areas. Exposure to more risk factors from social habits, lifestyle, and Helicobacter pylori infection has been considered the cause. However, even though gastric cancer has been repeatedly shown to be preventable by eliminating risk factors, eradication policies are rarely designed for Indigenous peoples. Possible obstacles may include the lack of Indigenous health statistics, inadequate access to care, difficulty in modifying social habits and lifestyles, and the presence of environmental and cultural barriers. Developing and implementing a preventive strategy following the evidence-based principle remains a challenge.

In Taiwan, the number of Indigenous peoples has grown; however, their life expectancy remains substantially lower than that of the non-Indigenous population. Cancer is the most prevalent cause of death for Indigenous peoples and a disproportionate prevalence of certain kinds of cancer is noted for Indigenous peoples. These observations provide an opportunity to establish a plan of action, in which a specific intervention is developed to decrease the threat from each specific cancer so that the overall disparate burden can be reduced in a stepwise manner.
Those randomized to CPAP will be fitted with CPAP face mask or nasal device by the respiratory therapist and permitted to trial the machine to ensure proper use and fit. CPAP settings: CPAP AUTO 5-20 cm H20 will be utilized. The CPAP device will then be removed. The subject will then be placed in the supine position with a standard roll placed under the right maternal hip. Those randomized to CPAP will have the device applied and machine turned on. For those randomized to routine airway management, nasal cannula with oxygen 2L/min will be applied and this will be titrated to achieve a maternal SpO2 \> 95%. End tidal CO2 monitors will be applied to both patient groups.
Protein supplementation will be provided through isolated whey protein, commonly known as whey protein isolate, which was generously donated by the Heroes Science Institute (HSI), as stated in the attached declaration. This whey protein isolate, with a vanilla flavor, is packaged in 25-gram sachets, each providing a total of 20 grams of protein per dose/sachet.
A hair coloring composition for oxidative dyeing of keratin-fiber is provided to suppress oxidation of green during storage, to decrease damage of hair by the green tea and to relieve stimulating odor and in dyeing surgical operation. A hair coloring composition for oxidative dyeing of keratin-fiber comprises the first agent and the second agent. The first agent comprises oxidation dye precursor, coupler, alkaline chemicals, green tea powder, water-soluble anti-oxidizer and reducing agent. The second agent comprises oxidizer. The water-soluble anti-oxidizer is one or more selected from a group consisting of ascorbic acid, erythorbic acid and salts thereof. The reducing agent is one or more selected from a group consisting of sodium nitrite, sodium metabisulphite, thioglycolic acid, thiolactic acid, cystein and salts thereof.
This article delves into the intricate interplay between tumors, particularly gynecologic malignancies, and neutrophil extracellular traps (NETs). The relationship between tumors, specifically gynecologic malignancies, and NETs is a multifaceted and pivotal area of study. Neutrophils, pivotal components of the immune system, are tasked with combating foreign invaders. NETs, intricate structures released by neutrophils, play a vital role in combating systemic infections but also play a role in non-infectious conditions such as inflammation, autoimmune diseases, and cancer. Cancer cells have the ability to attract neutrophils, creating tumor-associated neutrophils, which then stimulate the release of NETs into the tumor microenvironment. The impact of NETs within the tumor microenvironment is profound and intricate. They play a significant role in influencing cancer development and metastasis, as well as modulating tumor immune responses. Through the release of proteases and pro-inflammatory cytokines, NETs directly alter the behavior of tumor cells, increasing invasiveness and metastatic potential. Additionally, NETs can trigger epithelial-mesenchymal transition in tumor cells, a process associated with increased invasion and metastasis. The interaction between tumors and NETs is particularly critical in gynecologic malignancies such as ovarian, cervical, and endometrial cancer. Understanding the mechanisms through which NETs operate in these tumors can offer valuable insights for the development of targeted therapeutic interventions. Researchers are actively working towards harnessing this interaction to impede tumor progression and metastasis, opening up new avenues for future treatment modalities. As our understanding of the interplay between tumors and NETs deepens, it is anticipated that novel treatment strategies will emerge, potentially leading to improved outcomes for patients with gynecologic malignancies. This article provides a comprehensive overview of the latest research findings on the interaction between NETs and cancer, particularly in gynecologic tumors, serving as a valuable resource for future exploration in this field.
Participants received a single 0.5 milliliters (mL) dose of FluBlok vaccine from any of the Lots A, B, or C, intramuscularly on Day 0 (Visit 1). Participants were followed up to 6 months after vaccination.
Automatic test tracking analysis and reporting are provided by an automated process and computer system, which can provide a global communications network, for the convenience of patients, health care providers and public health agencies to lower health care costs. Advantageously, the speedy accurate process and system can be used to detect many types of infectious diseases, chronic diseases, genetic diseases, nutritional deficiency, environmental and general health problems, fertility, mental disorders, drug abuse, allergies, etc., as well as to automatically administer non-invasive tests, such as vision tests, hearing tests, and cognitive function tests to monitor the progress of Alzheimer's disease. Samples to be tested can be conveniently collected by the patient or by others and placed in a test kit at the patient's home or other location remote from a medical facility. The sample can be tested in a laboratory or at the patient home or other remote site. The test results and patient profile medical history can be inputted into the system or network and compared with data bases of diseases, disorders, treatments, care plans, nutritional supplements, and medicine. The process and system can transmit an analysis and proposed treatment to the patient's physician or health care provider for approval or change before the test report and recommended medicine and treatment are sent to the patient. The process and system are also useful for automatic test tracking and reporting to public health organizations.
BACKGROUND: Spleen preserving distal pancreatectomy is achieved by either splenic vessel resection or splenic vessel preservation. However, the long-term outcomes of spleen-preserving distal pancreatectomy with splenic vessel resection and spleen-preserving distal pancreatectomy with splenic vessel preservation are not well known. This study aimed to evaluate the long-term outcomes of spleen-preserving distal pancreatectomy with splenic vessel resection and spleen-preserving distal pancreatectomy with splenic vessel preservation.
METHODS: The study included a total of 335 patients who underwent spleen-preserving distal pancreatectomy during the study period and underwent computed tomography or magnetic resonance imaging 3 and 5 years after surgery in the Japan Society of Pancreatic Surgery member institutions. We evaluated the diameter of the perigastric and gastric submucosal veins, patency of the splenic vessels, and splenic infarction. Preoperative backgrounds and short- and long-term outcomes were compared between the 2 groups.
RESULTS: Forty-four (13.1%) and 291 (86.9%) patients underwent spleen-preserving distal pancreatectomy with splenic vessel resection and spleen-preserving distal pancreatectomy with splenic vessel preservation, respectively. There were no significant differences in short-term outcomes between the 2 groups. Regarding long-term outcomes, the prevalence of perigastric varices was higher (P = .006), and platelet count was lower (P = .037) in the spleen-preserving distal pancreatectomy with splenic vessel resection group. However, other complications, such as gastric submucosal varices, postoperative splenic infarction, gastrointestinal bleeding, reoperation, postoperative splenectomy, and other hematologic parameters, were not significantly different between the 2 groups 5 years after surgery. In terms of the patency of splenic vessels in spleen preserving distal pancreatectomy with splenic vessel preservation cases, partial or complete occlusion of the splenic artery and vein was observed 5 years after surgery in 19 (6.5%) and 55 (18.9%) patients, respectively.
CONCLUSION: Perigastric varices and thrombocytopenia were observed more in spleen-preserving distal pancreatectomy with splenic vessel resection, yet late clinical events such as gastrointestinal bleeding and splenic infarction are acceptable for spleen-preserving distal pancreatectomy with splenic vessel preservation.
1,150,210. Surgical sutures. J. SATSUMA. 14 Dec., 1966 [12 Jan., 19661, No. 56082/66. Heading A5R. [Also in Division Dl] In the production of a suture which is opaque to X-rays, filamentary material is immersed for from 10 to 1.5 minutes in an emulsion of barium sulphate at a temperature of from 35‹ to 40‹C and, after removal from the emulsion, is subjected to successive twisting, drying, surface smoothing and sterilizing processes prior to being sealed in an ampoule. The filamentary material may be a thread of silk or of synthetic resin. Alternatively the filamentary material may be catgut, in which case a strip (for example 2 metres long and 7 millimetres wide) of salted mammalian intestinum tenue .may be subjected, prior to immersion in the barium sulphate emulsion, to successive treatments of cleaning, removal of fat, bleaching and sterilizing. The barium sulphate emulsion may optionally con tain gelatin. The barium sulipihate is stated both to permeate into, and to be deposited on, the filamentary material
After completing the spontaneous breathing trial (SBT), with the extubation decision defined by the physician in charge of the patient and maximal expiratory pressure (MEP) as usually measured greater than 30 centimeters of water (cmH2O). Following this, the patient was allowed to rest for 5 minutes in the same condition. With the patient in the supine position sitting 45 ° to 60 °, the closed suction catheter was removed, an elbow was placed at 90 ° and a bacterial filter in series with the endotracheal tube (ET), an adapter was also coupled with a outlet port to the aneroid pressure gauge. In series an inspiratory unidirectional valve was placed that did not allow expiration. Immediately 2 ml of physiological solution was slowly instilled through the port in the 90º elbow to trigger the cough reflex. The presence or absence of reflex cough and the MEP during induced cough (MEPic) value were verified.

As a safety method, the procedures were stopped if the patient presented signs of intolerance such as respiratory rate (RF)\> 35 breaths per minute, saturation \<90%, heart rate (HR)\> 140 beats per minute or increase of 20 % of resting levels.
TriageGo-MDW CDS will be made available during all ED patient encounters at two points in the ED care continuum: (1) shortly after arrival during initial ED triage (First Triage) and (2) after initial laboratory results have been populated within the EHR. General illness severity estimates will be provided to nurses at ED triage in the form of recommended triage acuity scores (CDS for First Triage). General illness severity estimates along with estimated risk for specific outcomes including sepsis and septic shock will be presented to clinicians after laboratory results have populated (CDS for Early Assessment). TriageGO-MDW risk estimates will be generated by machine learning algorithms using routinely available clinical data as predictor inputs. Nurses and clinicians will receive risk estimates within existing EHR workflows, along with brief and rapidly interpretable explanations of the logic driving each risk estimate.
Cytotoxic prod. is prepd. by forming a covalent disulphide bridge between a cytotoxic cpd., the A chain of ricin, and antibody, and immunoglobulin or a specific immunoglobulin fraction of a given antigen, according to the parent patent. The A chain of ricin is purified by chromatography to give a crystalline prod. Cytotoxic prods. as described in the parent patent but in which the antibody is either fragment F (ab)'2 of anti-DNP antibody, or it is IgM anti-Thy 1.2 are also new. This is an addn. to FR 7827838. The purified chain A is free from non-specific toxicity to the cell system or animal organism and so the specificity of the prod. is solely that of the antibody used.