anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
To provide a composition for external use having an excellent skin roughing preventing efficacy.SOLUTION: There is provided a composition for external use which comprises a rice fermentation liquid by Bacillus coagulans and dipotassium glycyrrhizinate. The rice preferably is unpolished brown rice. In addition, the rice preferably is black rice. The Bacillus coagulans preferably is Monascus purpureus. The percentage content of the fermentation liquid in the composition for external use is preferably 1.0 mass% or more and 10.0 mass% or less. The percentage content of the dipotassium glycyrrhizinate in the composition for external use is preferably 0.0001 mass% or more and 0.0150 mass% or less.SELECTED DRAWING: None
The present invention discloses a microcapsule encapsulating a solid sunscreen and preparation and use thereof. The microcapsule comprises the solid sunscreen and a natural polymer. The solid sunscreen is encapsulated in a microcapsule formed of the natural polymer, wherein the solid sunscreen is an inorganic ultraviolet screening agent, an organic ultraviolet absorbent, or a mixture thereof. The natural polymer is agar, agarose, cellulose, chitosan, or a derivative thereof. The microcapsule of the present invention is useful in cosmetics, effectively prevents the solid sunscreen from decomposition, and reduces skin irritation as a result of the separation of the solid sunscreen from the skin. The natural polymer with hydrophilicity can cover blemish, improve skin feeling, and enhances the compatibility in the cosmetics.
Patients will receive best supportive care. Patients randomized to best supportive care may receive plasma should they require hospitalization for progression of COVID-19 disease.
One or more biomarkers (as listed in Table A at pages 4-22) are useful for predicting or identifying an increased risk of ovarian cancer. For instance, there is an expansion of SOX2 expressing cells in the normal fallopian tubes of subjects with ovarian cancer. The expression of other genes listed in Table A is found to be responsive to SOX2 ectopic expression. SOX2 and the other genes in Table A can act as biomarkers for the prediction and early diagnosis of ovarian cancer. A method for predicting ovarian cancer or identifying an increased risk of developing ovarian cancer in a subject comprises determining the expression level of one or more biomarkers from Table A. The determined expression level is used to predict ovarian cancer or identify an increased risk of developing ovarian cancer.
Evaluation criteria are left ventricular dimensions and function measured by echocardiography, aerobic capacity measured as peak oxygen uptake, quality of life, and the level of physical activity by questionnaires. Assessments will be made before and after the training program and at one year follow-up. Safety of HIIT will be assessed as incidence of adverse effects during the training program. Clinical events will be recorded as worsening of heart failure requiring intensified drug therapy (diuretics), ventricular arrhythmia, hospitalization due to cardiovascular disease, and all-cause mortality at one year follow-up. The core study has been initiated and endorsed by the European Association for Cardiovascular Prevention and Rehabilitation, Section for Basic and Translational Research, under the European Society of Cardiology, and allows for sub-studies involving one or more of the participating centers. Preliminary calculations suggest that a total number of 200 patients randomized 1:1:1 to the three intervention groups is needed to detect larger beneficial effects with HIIT with a p-value of 0.05 and statistical power of 0.90 (primary endpoint is reverse remodeling, assessed by comparison between groups of change in left ventricular end-diastolic dimension from baseline to 12 weeks).
Embodiments of the present invention described and shown in the specification and drawings include an apparatus and method of controlling pulmonary ventilation for a ventilator supplying a breathing gas to a patient via a breathing circuit that is in fluid communication with the lungs of the patient. The ventilator has a plurality of selectable ventilator setting controls governing the supply of ventilation support from the ventilator, each setting control selectable to a level setting. The ventilator preferably receives at least one ventilator setting parameter signal, each ventilator setting parameter signal indicative of the level settings of one ventilator setting control, monitors a plurality of output signals to determine the sufficiency of the ventilation support received by the patient, and controls the level settings of the ventilator setting controls in response to the received ventilator setting parameter signal and the output signals. The ventilator preferably utilizes a trainable neural network to determine the desired level settings of the ventilator setting controls. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims. 37 C.F.R. §1.72(b).
A method for cognitive brain training, psychological motivation, and recovery to be used in conjunction with physical exercise in order to reduce the effects of mental and physical fatigue and improve athletic performance. A plurality of input devices integrate ergonomically with different sports so as not to limit movement, eye -hand coordination or negatively impact physical training. Software, executable on a portable computing device is configured for a sport, enabling an athlete to perform physical and cognitive tasks at the same time. Metrics, formulas and algorithms combine the athlete's self-rated performance with real-time cognitive and physiological output metrics to provide reports of the athlete's performance for each workout and for all workouts overtime. Mental recovery and motivation protocols used to help athletes stay on task and recover from the physical training. Cognitive fatigue self-assessment tests used to help athletes determine their current level of mental fatigue and readiness to train.
Patients will receive certolizumab with 6 cycles of cisplatin \& pemetrexed. Cycle of chemo will be 3 weeks. Certolizumab will be adm in the following fashion: first dose administered at the time of treatment initiation, second dose will be given after 2 weeks of treatment, third dose after four weeks of treatment, \& subsequent doses given every 4 weeks thereafter. Patients will be monitored for progression of disease using RECIST 1.1 with scans to be performed every 6 weeks. Posttreatment biopsies will be performed at the time of treatment discontinuation. Two dose levels of certolizumab will be tested, 200mg \& 400mg. A non-therapeutic cohort of 10 patients with adenocarcinomas who will be undergoing standard of care treatment with platinum based chemotherapy + pemetrexed +/- bevacizumab will be consented for blood draws before each cycle of treatment. This blood will be analyzed for cytokines and will serve as a reference for the experimental arm.
PURPOSE:To provide an intestine-controlling food containing extract and/or powder of KIDACHI-ALOE (Aloe arborescens) and/or HABUSO (Cassia torosa) as essential component. CONSTITUTION:KIDACHI-ALOE (a fleshy perennial low plant of Liliaceae family) and/or HABUSO (annual grass of Leguminosae family; aboveground part except for seeds; the aboveground part except for seeds of HOSOHABUSO (Cassia sophera), EBISUGUSA (Cassia obtusifolia), etc. which are family of HABUSO can be used suitably for the purpose) is washed e.g. by bleaching, cut to fine pieces, and freeze-dried, or is dried immediately after washing (by spontaneous drying, or hot-air drying), and pulverized. The objective intestine- controlling agent free from side effects can be produced by using the crushed product as an essential component. The content of the component in the composition is >=40wt%. It can be administered in the form of refreshing beverage, particle, granule, pill, powder, etc., at a dose of 500-10,000mg (powdery extract) per dose. The agent is effective to mildly stimulate the peristaltic movements of the intestines.
Conditions such as acute pancreatitis, ulcerative colitis, delayed graft function and infections caused by a variety of microorganisms, including gram-positive and gram-negative organisms, increase the risk of sepsis and therefore mortality. Immune dysfunction is a characterization of sepsis, so timely and effective treatment strategies are needed. The conventional approaches, such as antibiotic-based treatments, face challenges such as antibiotic resistance, and cytokine-based treatments have shown limited efficacy. To address these limitations, a novel approach focusing on membrane receptors, the initiators of the inflammatory cascade, is proposed. Membrane receptors such as Toll-like receptors, interleukin-1 receptor, endothelial protein C receptor, μ-opioid receptor, triggering receptor expressed on myeloid cells 1, and G-protein coupled receptors play pivotal roles in the inflammatory response, offering opportunities for rapid regulation. Various membrane receptor blockade strategies have demonstrated efficacy in both preclinical and clinical studies. These membrane receptor blockades act as early stage inflammation modulators, providing faster responses compared to conventional therapies. Importantly, these blockers exhibit immunomodulatory capabilities without inducing complete immunosuppression. Finally, this review underscores the critical need for early intervention in acute inflammatory and infectious diseases, particularly those posing a risk of progressing to sepsis. And, exploring membrane receptor blockade as an adjunctive treatment for acute inflammatory and infectious diseases presents a promising avenue. These novel approaches, when combined with antibiotics, have the potential to enhance patient outcomes, particularly in conditions prone to sepsis, while minimizing risks associated with antibiotic resistance and immune suppression.
Each 50 mL glass vial contains 50 mg of argatroban (1 mg/mL); and, as supplied, is ready for intravenous infusion. Dilution is not required.

Argatroban in Sodium Chloride injection is a clear, colorless to pale yellow solution. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Do not use if the solution is cloudy, contains precipitates, or if the flip off seal is not intact.

Vial may be inverted for use with a medical infusion set.
Participants received placebo for 2 days. modafinil on the third day and did not participate in the TRIER social stress task on the third day.
The application relates to the technical field of biological medicine, and provides an application of a DLAT gene as a target spot in preparing or screening a medicine for preventing and/or treating non-small cell lung cancer (NSCLC). Wherein the nucleotide sequence of the DLAT gene is shown as SEQ ID No. 1. The expression level of the DLAT gene in NSCLC cell line and NSCLC cancer tissue is obviously higher than that of normal epithelial cell line of lung and cancer tissue. High DLAT expression in NSCLC cancer tissues is significantly associated with poor prognosis in patients. DLAT has obvious functions of promoting NSCLC tumor cell proliferation and inhibiting apoptosis, and when the expression of DLAT is knocked down, the proliferation of NSCLC cells is inhibited and the apoptosis is promoted. Thus, the DLAT gene as a target can be used for screening or preparing a medicament for preventing and/or treating NSCLC.
INTRODUCTION: Operative volume is associated with improved outcomes across many surgical specialties, but this relationship has not been illustrated clearly in trauma. This study sought to evaluate the relationship between operative trauma volume and mortality, hypothesizing that increased volume would be associated with improved survival.
MATERIALS AND METHODS: The National Trauma Data Bank was queried for patients ≥18 y undergoing hemorrhage control surgery at level I or II trauma centers from 2017 to 2020. Hierarchical logistic regression was performed to evaluate the association between operative volume and in-hospital mortality, controlling for demographic and clinical characteristics.
RESULTS: 55,469 patients were included and treated at 516 centers. After adjustment, the operative volume was significantly associated with reduced mortality (OR 0.999, 95% CI 0.997-0.999, P = 0.018). However, there was considerable variability in volumes, with the busiest 5% of centers performing 90-294 operations per year, compared to 7-35 in the middle 50% of centers. To evaluate whether volume exhibited a uniform effect, the top 5% of trauma centers were excluded on subset analysis, with operative volume becoming nonsignificant in the remaining 491 centers (OR 0.999, 95% CI 0.996-1.001, P = 0.274).
CONCLUSIONS: Higher operative trauma volume is associated with reduced mortality for patients undergoing hemorrhage control surgery, but this mortality benefit appears to arise solely from very high-volume centers. The time-sensitive nature of hemorrhage control surgery makes centralization at this level impractical. Future efforts should focus on investigating the relationship between patient proximity to trauma centers and center volume as well as identifying modifiable factors common to high-volume centers that may be widely implemented.
PCT No. PCT/GB94/02447 Sec. 371 Date May 7, 1996 Sec. 102(e) Date May 7, 1996 PCT Filed Nov. 8, 1994 PCT Pub. No. WO95/13046 PCT Pub. Date May 18, 1995A water-insoluble porous cross-linked polymeric matrix contains an antiperspirant in its pores, the pores being interconnected to permit the antiperspirant to be leached therefrom with water, with zero order release without change in pore geometry. The pores may additionally contain one or more other materials such as deodorants, moisturizers, lubricants and perfumes. The matrix can be shaped for application to the skin. An antiperspirant dispenser can comprise a matrix of the invention with a water reservoir therefor.
Interventions to increase physical activity through aerobic exercise are some of the only known treatment options to improve domains of cognition such as executive function. While increased physical activity is associated with preserved cortical functioning during exogenous executive functioning tasks in older adults, little is known about the relationship between physical activity and executive functioning in multiple sclerosis. Thus, the investigators propose to conduct a randomized 6-month accelerometry-based intervention designed to increase overall physical activity in sedentary relapsing-remitting multiple sclerosis with known cognitive challenges. The overall objective is to determine how a 6-month activity tracking intervention impacts the behavioral, neural and mechanistic associations between physical activity and cognitive functioning. All individuals who contact the Clinical Neuroscience Laboratory (CNL) with interest in this study will undergo a phone/online screening assessing inclusion/exclusion criteria. Those participants meeting I/E criteria will be invited to the lab for 2 pre-assessment sessions, one session at midpoint, and 2 post-assessment sessions at the completion of the 6 month intervention. Participants will also be asked to complete a number of online questionnaires following the first assessment session. The two pre-assessments will involve a through measure of cognitive functioning, both through the use of neuropsychological batteries and neuroimaging, and inflammatory markers through collection of a blood sample. Following the pre-assessment sessions, conducted by blind personnel, participants will be randomized to one of the two groups. Participants will be asked to self-monitor their assigned health behavior with the aid of a behavioral tracker (accelerometer or smart water bottle). Via a mobile application designed by the laboratory, participants will receive daily and weekly summaries of their health behavior progress, and motivational materials to encourage goal attainment. The 6-month intervention will involve minimal contact from study coordinators. Participants who do not adhere to study goals will be contacted by a study coordinator via phone who will use motivational interviewing to promote behavior change. Following the 6-month intervention the 2 assessment sessions will be repeated to obtain post-intervention data for comparison.
Both couple members offered incentives and tracked across 12 months. Both targets and partners will be offered financial incentives for abstinence. Thus, in this condition, the total financial incentives offered to the dyad are twice the amount as offered to participants in the SFIT condition.
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes in chromosomes. CIN arises from errors in DNA replication and chromosome segregation during cell division, leading to the formation of cells with abnormal number and/or structure of chromosomes. Errors in DNA replication result from abnormal replication licensing as well as replication stress, such as double-strand breaks and stalled replication forks; meanwhile, errors in chromosome segregation stem from defects in chromosome segregation machinery, including centrosome amplification, erroneous microtubule-kinetochore attachments, spindle assembly checkpoint, or defective sister chromatids cohesion. In normal cells, CIN is deleterious and is associated with DNA damage, proteotoxic stress, metabolic alteration, cell cycle arrest, and senescence. Paradoxically, despite these negative consequences, CIN is one of the hallmarks of cancer found in over 90% of solid tumors and in blood cancers. Furthermore, CIN could endow tumors with enhanced adaptation capabilities due to increased intratumor heterogeneity, thereby facilitating adaptive resistance to therapies; however, excessive CIN could induce tumor cells death, leading to the "just-right" model for CIN in tumors. Elucidating the complex nature of CIN is crucial for understanding the dynamics of tumorigenesis and for developing effective anti-tumor treatments. This review provides an overview of causes and consequences of CIN, as well as the paradox of CIN, a phenomenon that continues to perplex researchers. Finally, this review explores the potential of CIN-based anti-tumor therapy.
FIELD: medicine. ^ SUBSTANCE: invention relates to veterinary. Pharmaceutical composition for treatment of ear infection in animals contains orbifloxacin or one of its pharmaceutically acceptable salts, efficient amount of antifungal pharmaceutically acceptable triazole compound, mometasone furoate monohydrate and at least one pharmaceutically acceptable carrier, where said composition represents suspension. Pharmaceutical composition for treatment of infection in animals contains orbifloxacin or one of its pharmaceutically acceptable salts, efficient amount of antifungal compound, represented by chemical structural formula I: mometasone furoate monohydrate and at least one pharmaceutically acceptable carrier, where said composition represents suspension. Pharmaceutical composition for treatment of ear infection in animals contains quinol antibiotic, efficient amount of antifungal pharmaceutically acceptable triazole compound, mometasone or one of its pharmaceutically acceptable salts, and at least one pharmaceutically acceptable carrier, where said composition represents suspension. ^ EFFECT: said pharmaceutical compositions ensure increase of animal treatment efficiency and reduction of irritating action in place of introduction. ^ 17 cl, 1 ex, 1 dwg, 1 tbl
A compound comprising (I) or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein. A  compound having an .omega. chain comprising (II) or a derivative thereof, or a pharmaceutically acceptable salt or a prodrug thereof, is disclosed.  Derivatives, salts and prodrugs are identified and described in detail.  Methods of treating certain conditions or diseases, and compositions and medicaments related thereto are also contemplated.
Two schools (all students grades 9-12) will serve as the intervention group.Participants will complete a baseline survey that will take no longer than 30 minutes. Afterwards, a trained facilitator will delivery a game-based bystander intervention program aimed at teaching students the knowledge and skills to prevent or intervene in instances in sexual harassment and violence among peers. This will last for 4 class periods (approximately 45 minutes each period, 180 minutes total). Afterwards, participants will complete an immediate post-program survey lasting no more than 30 minutes. Three months later, students will fill out an a follow up survey lasting no more than 30 minutes. School staff and administrators will be interviewed to gather their insights on the program's feasibility and acceptability.
Higher OT temperature with placebo This group will receive one non-pharmacological intervention, which is higher OT temperature 19-22 degree celsius. The aim of this intervention is to reduce heat loss therefore incidence of PSS for obstetric population coming for lower segment cesarean section (LSCS) by reducing the temperature gradient between the body and environment.
Atherosclerosis is a chronic vascular disease. Its prevalence increases with aging. However, atherosclerosis may also affect young subjects without significant exposure to the classical risk factors. Recent evidence indicates clonal hematopoiesis of indeterminate potential (CHIP) as a novel cardiovascular risk factor that should be suspected in young patients. CHIP represents a link between impaired bone marrow and atherosclerosis. Atherosclerosis may present with an acute symptomatic manifestation or subclinical events that favor plaque growth. The outcome of a plaque relies on a balance of innate and environmental factors. These factors can influence the processes that initiate and propagate acute plaque destabilization leading to intraluminal thrombus formation or subclinical vessel healing. Thirty years ago, the first autopsy study revealed that coronary plaques can undergo rupture even in subjects without a known cardiovascular history. Nowadays, cardiac magnetic resonance studies demonstrate that this phenomenon is not rare. Myocardial infarction is mainly due to plaque rupture and plaque erosion that have different pathophysiological mechanisms. Plaque erosion carries a better prognosis as compared to plaque rupture. Thus, a tailored conservative treatment has been proposed and some studies demonstrated it to be safe. On the contrary, plaque rupture is typically associated with inflammation and anti-inflammatory treatments have been proposed in response to persistently elevate biomarkers of systemic inflammation. In conclusion, atherosclerosis may present in different forms or phenotypes. Vulnerable patient phenotypes, identified by using intravascular imaging techniques, biomarkers, or even genetic analyses, are characterized by distinctive pathophysiological mechanisms. These different phenotypes merit tailored management.