anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Excessive or insufficient gestational weight gain (GWG) leads to diverse adverse maternal and neonatal outcomes. There is evidence that pregestational body mass index (pBMI) plays a role in GWG, but no genetic cause has been identified. In this review, we aim to analyze genotype variants associated with GWG. Results: We identified seven genotype variants that may be involved in GWG regulation that were analyzed in studies carried out in Brazil, Romania, the USA, Turkey, Ukraine, and Canada. Some genetic variants were only associated with GWG in certain races or depending on the pBMI. In women who were obese or overweight before gestation, some genetic variants were associated with GWG. Environmental and genetic factors together showed a greater association with GWG than genetic factors alone; for example, type of diet was observed to have a significant influence. Conclusions: We found little scientific evidence of an association between genotype variants in countries with a high prevalence of women of reproductive age who are overweight and obese, such as in Latin America. GWG may be more dependent on environmental factors than genetic variants. We suggest a deeper study of genetic variants, cytokines, and their possible association with GWG, always with the respective control of potential cofounding factors, such as pBMI, diet, and race.
Patients with infections and a SOFA score of 1 will be screened and confirmed by a physician to meet the inclusion criteria. After obtaining informed consent, a nurse will collect a 4 cc blood sample within 24 hours of qualification. Within 7 days of ICU admission, physicians will assess whether patients with non-sepsis infections progress to sepsis. If so, these patients will be categorized into the sepsis patient group. One week post-discharge and on the 28th day post-diagnosis, a nurse will follow up to inquire about their health status.
The other half of the health facilities will implement the standard of care (SoC). Enrolled mothers will not receive immediate PoC VL at delivery, but infants deemed to be at high risk using clinical criteria (e.g. no or late initiation of maternal ART) will be offered ePNP. EID testing will follow the national algorithm with testing at 4-8 weeks, followed by referral for immediate ART initiation for all HIV-infected infants. As PoC EID testing is expected to be nationally implemented on a programme level we will facilitate the availability of PoC testing at these sites.
Brentuximab vedotin 1.4 mg/kg, 30-minute IV infusion, Day 1 of every 21-day cycle, until there was evidence of disease progression or unacceptable toxicity. Dose was escalated up to 1.8 mg/kg using a 3 + 3 dose escalation design to determine a maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) depending upon the dose limiting toxicity (DLT).
The specification discloses a method, a device, a storage medium and electronic equipment for information display. First, the patient's visit text data and the patient's medical image data are acquired. And secondly, selecting a knowledge graph corresponding to a target operation scheme to be executed of the patient from knowledge graphs corresponding to various operation schemes constructed in advance, and taking the knowledge graph as a target knowledge graph. Then, for each surgical risk corresponding to the target surgical scheme, the diagnosis text data, the medical image data and the target knowledge graph are input into a pre-trained prediction model corresponding to the surgical risk, and the probability that the surgical risk occurs to the patient when the target surgical scheme is executed is predicted. And then constructing a fusion knowledge graph corresponding to the patient. And finally, displaying the fusion knowledge graph. The method can improve the communication efficiency between doctors and family members.
Background: Despite excellent survival rates, health-related quality of life detriments are common in differentiated thyroid cancer survivors and can be driven by fear of cancer recurrence (FCR). This review aims to report the incidence of FCR in thyroid cancer survivors and synthesize evidence regarding contributing factors. An overview and appraisal of the range of tools used to measure FCR is presented. Methods: A systematic review of the English literature was performed. The search across six electronic databases generated 3414 studies. Two reviewers independently screened the citations and full-text articles, of which 31 were included. The data were extracted independently by two reviewers. Results: The incidence of FCR was reported in 27/31 studies and ranged from 15% to 91%. Direct comparisons regarding incidence and severity of FCR were not possible due to heterogeneity in cut-points used to define FCR. A total of eight validated tools were used to measure FCR across all studies, with five studies using self-developed nonvalidated items. There was minimal repetition of validated tools and no clear consensus as to a preferred survey tool. Factors influencing FCR were reported in 11 studies. There was minimal overlap of factors influencing FCR. Risk factors contributing to increased FCR reported in more than one study included young age and an upcoming clinical appointment. Male gender and higher education levels were reported in more than one article as protective. No literature evaluating interventions to address FCR in thyroid cancer survivors was found. Conclusion: FCR is common in thyroid cancer survivors, but significant heterogeneity in the current evidence base limits assessment of incidence, severity, or risk factors. There is a need to use validated tools to assess FCR in both research and clinical contexts. Reliable assessment of FCR may permit routine assessment of FCR in clinical practice and allow interventions to be prospectively evaluated to optimize the holistic well-being of thyroid cancer survivors.
BACKGROUND: Knobloch syndrome (KNO, OMIM # 267,750) is a rare ciliopathy group sydrome characterized by a collagen synthesis disorder. It represents an uncommon cause of pediatric retinal detachment. This report presents two cases with different COL18A1 gene mutations, complicated by retinal detachment.
CASE PRESENTATION: Both cases exhibited high myopia and various degrees of occipital skull defect. The first case, a female, had bilateral congenital retinal detachment, posterior embryotoxon, and strabismus. The second case, a male, had unilateral congenital retinal detachment and neuromotor developmental delay. The first case, diagnosed in the early months of life, underwent successful retinal reattachment surgery. However, surgery was not performed on the second case, who presented with late-stage unilateral retinal detachment and pre-phthisis.
CONCLUSIONS: The report describes two patients with Knobloch syndrome, one of whom responded favorably to surgery for retinal detachment in both eyes. Successful anatomical results were achieved with early surgical interventions. It is essential to recognize the phenotypic and genetic heterogeneity within KNO.
Accidental removal of IV catheters delay patient care and can cause additional medical anxiety and pain that is heightened in the pediatric population. Moreover, such failed catheters create an increased burden economically and emotionally to patients, hospitals, and clinicians. To facilitate the most accurate, consistent results, a calibrated hand wheel test stand with a force gauge will be used to obtain force measurements. We will obtain the amount of force is required to remove the IV catheter form the skin of the subjects to compare the three taping measurements in two different directions. The retrograde direction will be pulling the IV distally from the IV site, towards the participant's wrist. The 90-degree angle will be pulling the IV medially away from the IV site.
Children aged 8-12 and at least one caregiver will meet for 10 weekly face-to-face and online intervention sessions (1.5 hours per session). Four biweekly maintenance sessions will follow the main program.
Systems, methods, and computer program products are provided for ranking plant-based products based on consistency of formulation. In various embodiments, a method is provided where a plurality of plant-based products are read from a datastore. Each plant- based product is characterized by a product feature vector comprising a prevalence of a plurality of cannabinoids, terpenes, and other active ingredients. The feature vectors are clustered into a plurality of clusters. Each cluster is labeled with a disease or wellness indication. The plant-based products are ranked for a selected disease or wellness indication based on the consistency of each formulation.
A method for treating chronic recurrent aphthous stomatitis in the patients with celiac disease comprises the use of vitamins of B group, the diet, the topical therapy with glucocorticoid ointment. Cutiveit is applied for this purpose for 15-20 minutes. The drug is applied with the aid of the sterile cotton swab 3-5 times a day. The mouthwash Lysodent is used 4-5 times a day for 7-14 days. The toothpaste Argital is used 2-3 times a day for 3-5 minutes. Gluten-free diet is provided.
NEW MATERIAL:The tetrahydro-2H-1,3,5-thiadiazine-2-thione derivative of formula I (R<1> is methyl or ethyl; X is S, O or N-R<3>-N=CH-; R<2> is H or lower alkyl; R<3> is lower alkyl). EXAMPLE:3,5-Dimethyl-4,6-di(2-thienyl)-tetrahydro-2H-1,3,5-thiadiazine -2-thione. USE:The compound has antibacterial activity and hypolipemic action and is useful as a drug. PREPARATION:The objective compound of formula I can be produced by the cyclization reaction of the compound of formula II with carbon disulfide. The starting compound of formula II can be synthesized by reacting a primary amine of formula III with a heterocyclic aldehyde of formula IV at 0-30 deg.C in a solvent such as benzene, toluene, etc., and distilling out produced water by azeotropic distillation. The amount of carbon disulfide is 1mol or 2-3mol per 1mol of the compound of formula II.
This study will demonstrate using measures of effectiveness, the feasibility of partnering with the community to create, disseminate, implement and evaluate Shape Up Somerville: Eat Smart. Play Hard., a community-based environmental change intervention to prevent obesity in culturally diverse, high-risk, early elementary school children. Based on formative work with parents, children, teachers, school food service, school officials, and community members, a community-wide campaign will be developed with targeted environmental change strategies for early elementary school children within the before-, during-, and after-school environments reinforced by changes within the home and community to support behavioral action and maintenance. The intervention targeting children will bring the energy equation into balance by offering numerous physical activity options that total up to 125 kcals per day and by improving the composition of the food served and the dietary options, particularly snack foods, available throughout the day. This study will measure awareness and participation of the partners and residents within the community. In addition the temporal change in BMI z-score will be monitored internally in 700 Somerville children and externally in 1000 control children from 2 demographically-matched communities for one year and will be compared to the change in BMI z-score in children participating in Shape Up Somerville with children from control communities over the one-year intervention and for one year of follow up. If successful, Somerville will serve as the model community that paves the way for cost-effective nationwide environmental action to prevent obesity at the community level.
PROBLEM TO BE SOLVED: To provide an electronic filing system capable of efficiently registering the image of a prescription or the like. SOLUTION: A processing control part acquires a patient list file from a reception computer (step S11) and stores the acquired patient list file in a memory. An image reader reads the prescription (step S12). The read prescription image is stored in the memory. A processing control part acquires the character data of a reception number by recognizing the characters of character images contained in the prescription image stored in the memory (step S13). With the acquired reception number as a retrieval key, the processing control part retrieves the patient information from the patient list file stored in the memory (step S14). Then, the acquired patient information and the prescription image are correspondently registered in a storage part (step S15). The processing control part repeats processing as much as all prescriptions.
Spinocerebellar ataxia type 3 (SCA3), or Machado-Joseph disease, presents as a cerebellar cognitive affective syndrome (CCAS) and represents the predominant SCA genotype in Taiwan. Beyond cerebellar involvement, SCA3 patients exhibit cerebral atrophy. While prior neurodegenerative disease studies relied on voxel-based morphometry (VBM) for brain atrophy assessment, its qualitative nature limits individual and region-specific evaluations. To address this, we employed fractal dimension (FD) analysis to quantify cortical complexity changes in SCA3 patients. We examined 50 SCA3 patients and 50 age- and sex-matched healthy controls (HC), dividing MRI cerebral gray matter (GM) into 68 auto-anatomical subregions. Using three-dimensional FD analysis, we identified GM atrophy manifestations in SCA3 patients. Results revealed lateral atrophy symptoms in the left frontal, parietal, and occipital lobes, and fewer symptoms in the right hemisphere's parietal and occipital lobes. Focal areas of atrophy included regions previously identified in SCA3 studies, alongside additional regions with decreased FD values. Bilateral postcentral gyrus and inferior parietal gyrus exhibited pronounced atrophy, correlating with Scale for the Assessment and Rating of Ataxia (SARA) scores and disease duration. Notably, the most notable focal areas were the bilateral postcentral gyrus and the left superior temporal gyrus, serving as imaging biomarkers for SCA3. Our study enhances understanding of regional brain atrophy in SCA3, corroborating known clinical features while offering new insights into disease progression.
CNS stimulants have been associated with weight loss and slowing of growth rate in pediatric patients.

In a 4-week, placebo-controlled trial of lisdexamfetamine dimesylate capsules in pediatric patients ages 6 to 12 years old with ADHD, there was a dose-related decrease in weight in the lisdexamfetamine dimesylate groups compared to weight gain in the placebo group. Additionally, in studies of another stimulant, there was slowing of the increase in height [see Adverse Reactions (6.1)].

Closely monitor growth (weight and height) in lisdexamfetamine dimesylate-treated pediatric patients. Patients who are not growing or gaining height or weight as expected may need to have their treatment interrupted. Lisdexamfetamine dimesylate capsules are not approved for use in pediatric patients below 6 years of age [see Use in Specific Populations (8.4)].
To explore the developmental processes of epileptogenesis/ictogenesis, this study determined age-dependent functional abnormalities associated with purinergic transmission in a genetic rat model (S286L-TG) of autosomal-dominant sleep-related hypermotor epilepsy (ADSHE). The age-dependent fluctuations in the release of ATP and L-glutamate in the orbitofrontal cortex (OFC) were determined using microdialysis and ultra-high-performance liquid chromatography with mass spectrometry (UHPLC-MS). ATP release from cultured astrocytes was also determined using UHPLC-MS. The expressions of P2X7 receptor (P2X7R), connexin 43, phosphorylated-Akt and phosphorylated-Erk were determined using capillary immunoblotting. No functional abnormalities associated with purinergic transmission could be detected in the OFC of 4-week-old S286L-TG and cultured S286L-TG astrocytes. However, P2X7R expression, as well as basal and P2X7R agonist-induced ATP releases, was enhanced in S286L-TG OFC in the critical ADSHE seizure onset period (7-week-old). Long-term exposure to a modest level of P2X7R agonist, which could not increase astroglial ATP release, for 14 d increased the expressions of P2X7R and connexin 43 and the signaling of Akt and Erk in astrocytes, and it enhanced the sensitivity of P2X7R to its agonists. Akt but not Erk increased P2X7R expression, whereas both Akt and Erk increased connexin 43 expression. Functional abnormalities, enhanced ATP release and P2X7R expression were already seen before the onset of ADSHE seizure in S286L-TG. Additionally, long-term exposure to the P2X7R agonist mimicked the functional abnormalities associated with purinergic transmission in astrocytes, similar to those in S286L-TG OFC. Therefore, these results suggest that long-term modestly enhanced purinergic transmission and/or activated P2X7R are, at least partially, involved in the development of the epileptogenesis of ADSHE, rather than that of ictogenesis.
BACKGROUND: This study aimed to determine the nature, frequency, and characteristics of medical emergencies occurring at the King Abdulaziz University Dental Hospital.
MATERIALS AND METHODS: The incident reports of medical emergencies recorded at the King Abdulaziz University Dental Hospital from January 2008 to December 2022 were retrospectively reviewed. The annual/overall incidence of medical emergency events was calculated per 100,000 patients. The following characteristics of the patients/events were evaluated: age, gender, operator, procedure, location, timing of treatment, administration of local anesthesia, past medical history, symptoms, diagnosis, outcome, and disposition. Multivariable logistic regression models were used to investigate the associations of these characteristics with two outcomes: syncope and transfer to the emergency room (ER).
RESULTS: The incidence of emergency events was 17.4 per 100,000 patients. Syncope and hypoglycemia were the most common emergencies. Most incidents recovered, with only 13% requiring transfer to the ER. Undergoing no procedure and American Society of Anesthesiologists (ASA) class 2,3 were associated with syncope. Undergoing a general dental procedure, ASA class 2,3, and a diagnosis other than hypoglycemia and syncope were associated with transfer to the ER.
CONCLUSIONS: The incidence of medical emergencies was low. Dental practitioners need to remain aware of the contributing factors, such as past medical history and anxiety, but medical emergencies can occur in healthy individuals as well. Preparation of the dental office, training of the personnel, and proper recording of the events are essential components of a well-established medical emergency protocol in dental institutions.
The present invention relates to a phytochemical formulation for maintaining a healthy gut micro biota with controlling the inflammatory bowel disease symptoms. The phytochemical formulation comprises dietary fibers obtained from Curcuma longa at a concentration of 90%-95%, standardized curcuminoids obtained from Curcuma longa at a concentration of 2% to 5% and Ferula asafoeitida extract at a concentration of 1% to 3%. Curcuminoids and Ferula asafoeitida extract are encapsulated onto the dietary fibers to form a complex. The formulation of the present invention is a complex of polar and non-polar molecules prepared using the PNS technology, which increases the bio efficacy of nutraceutical ingredients. The formulation is prepared in powdered form using spray drying technology. The formulation is safe, effective in improving the gut health by maintaining gut microbiota in humans.
An apparatus to provide scent or other substances ( e.g.,  active agent) includes a thin profile delivery apparatus that includes an actuator ( e.g. , nebulizer) and drive circuit to generate a spray, aerosol or vapor. The apparatus may have a slot to removably a media cartridge that carries the scent or other substances. The apparatus may include two contacts  (e.g.,  buttons), opposed to one another across a dimension of the apparatus. Activation may require both engagement of both contacts, for instance concurrently, or even successive engagement of both contacts, in quick succession. Activation may further require a correct orientation of the apparatus. The apparatus may have a form factor similar to a conventional credit or debit card, and may be pliable or pliably resilient. The delivery apparatus can be used in entertainment ( e.g. , food or cooking programming), and in healthcare ( e.g.,  control of metabolism).
Endogenic factor which binds to the same site as benzodiazepines is isolated by grinding of brain or cortex which is either freshly removed or frozen, homogenising in water, centrifuging the obtd. suspension, followed by dialysis and/or ultrafiltration of the supernatant to obtain the desired endogenic factor having mole wt. 1000. The endogenic factor, DDS (diazepam displacement substance) may be the neuro-transmitter which controls anseiolytic activity and is able to displace benzodiazepines from their receptors. The brain or cortex may be obtd. from rats, cats, horses, monkeys, pigs or humans. It is homogenised in the cold with 10-50 vols. of distilled water. The suspension is centrifuged at 50,000 g for 60 mins. Ultrafiltration is effected in an Amicon type appts. with filters of appropriate pore size for the mol. wt. range.
ORIAHNN is contraindicated in women with known osteoporosis [see Contraindications (4)]. ORIAHNN may cause a decrease in bone mineral density (BMD) in some patients. BMD loss is greater with increasing duration of use and may not be completely reversible after stopping treatment [see Adverse Reactions (6.1)]. 

In the Phase 3 clinical trials (Studies UF-1, UF-2, and UF-3) [see Clinical Studies (14)], seven out of 453 (1.5%) ORIAHNN-treated women experienced fractures, including one (0.2%) with a fragility fracture, compared to one out of 196 (0.5%) placebo-treated women (patient had a non-fragility fracture). Five of the seven ORIAHNN-treated women reported these fractures in the post-treatment follow-up period. The impact of BMD decreases on long-term bone health and future fracture risk in premenopausal women is unknown. 

Consider the benefits and risks of ORIAHNN treatment in patients with a history of a low-trauma fracture or other risk factors for osteoporosis or bone loss, including taking medications that may decrease BMD (e.g., systemic or chronic inhaled corticosteroids, anticonvulsants, or proton pump inhibitors). 

Assessment of BMD by dual-energy X-ray absorptiometry (DXA) is recommended at baseline and periodically thereafter. Consider discontinuing ORIAHNN if the risk associated with bone loss exceeds the potential benefit of treatment. Limit the duration of use to 24 months to reduce the extent of bone loss [see Indications and Usage (1) and Dosage and Administration (2.1)]. 

Although the effect of supplementation with calcium and vitamin D was not studied, such supplementation for patients with inadequate dietary intake may be beneficial.
The GameDay Ready Program is a 12-week, football-themed, behavioral weight management intervention that promotes gradual increases in physical activity, reductions in sedentary time, and improvements in dietary habits through education, self-monitoring of physical activity and diet, personalized goal setting, group-based competition, social support, identifying and overcoming barriers, and including physical activity as a substantial component of meeting sessions. The program is sensitive to unique cultural influences surrounding gender, race, and rurality; and issues related to motivation are threaded throughout the program.