anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This invention provides an isolated nucleic acid molecule encoding a Tumor necrosis factor Receptor-Associated Factor (TRAF) protein-interacting hereditary multiple extoses (TREX) protein. This invention also provides vectors comprising the isolated nucleic acid molecule encoding a TREX protein. This invention further provides a purified TREX protein and antibodies thereto. This invention provides oligonucleotides comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of an isolated nucleic acid molecule encoding TREX protein. This invention provides an antisense oligonucleotide comprising a sequence capable of specifically hybridizing with a unique sequence included within a genomic DNA molecule encoding a Tumor necrosis factor Receptor-Associated Factor (TRAF) protein-interacting hereditary multiple extoses (TREX) protein. This invention provides a monoclonal antibody directed to an epitope of a TREX protein. This invention provides methods of inhibiting TREX protein interaction with a TRAF protein; of inhibiting overexpression of TREX protein; of inhibiting growth of a tumor; of treating abnormalities in a subject associated with overexpression of TREX. This invention provides pharmaceutical compositions comprising oligonucleotides effective to prevent overexpression of a TREX protein or antibodies effective to block binding of a TREX protein to a TRAF protein; screening for compounds which inhibit TREX protein and TRAF protein binding; of detecting predispositions to cancers comprising TREX mutations; and of diagnosing cancer comprising TREX mutations.
The invention discloses a medicine for treating obsolete sprain and bruise. The medicine is prepared by traditional Chinese medicine raw materials by weight percent as follows: 10g of fried Eucommia ulmoides, 15g of parasitic loranthus, 10g of fox, 10g of pseudo-ginseng, 10g of peach kernel, 10g of flowers carthami, 10g of dried body of ground beetle, 15g of Caulis Spatholobi, 15g of Angelica sinensis, 10g of Ligusticum wallichii, 15g of Rehmannia Glutinosa, 15g of the fruit of Chinese wolfberry, 15g of pulp of dogwood fruit, 10g of poria, 10g of poria and 10g of liquorice. The traditional Chinese medicines disclosed by the invention are obtained by clinical component compatibility for several times. The taken medicine can directly reach the affected part to treat both symptoms and root causes. The medicine has the effects of strengthening the bones and muscles, filling marrow, removing blood stasis, continuing muscles and bones, invigorating the circulation of blood and dredging the muscle, dissipating blood stasis and relieving pain and the like, and can quickly relieve pain and swelling, promote blood circulation to remove blood stasis, and set bone and continue muscle so as to treat. Clinical experiments of over 100 cases show that the medicine is remarkable in curative effect for treating obsolete sprain and bruise and high in cure rate.
The present invention discloses a preparation which contains cetirizine hydrochloride and hydrochloric pseudoephedrine and a preparation method thereof. The preparation is a double-layer coating core, wherein a core of the preparation contains hydrochloric pseudoephedrine whose quantity reaches the treatment effective dose and a carrier which can be medically accepted, and an outer layer of the preparation contains a preparation which contains cetirizine hydrochloride whose quantity reaches the treatment effective dose and a carrier which can be medically accepted. An inner layer tablet which contains the hydrochloric pseudoephedrine is firstly prepared, and the inner layer tablet is then coated with an outer layer tablet which contains the cetirizine hydrochloride. The present invention solves the problem that cetirizine hydrochloride is quickly released. Simultaneously, the requirement that hydrochloric pseudoephedrine is slowly released is satisfied. The released quantity of the cetirizine hydrochloride can reach more than 70%(90%) in half an hour (an hour), and the hydrochloric pseudoephedrine can be slowly released in 12 hours or 24 hours. The drug effect is stably kept, and therefore, the number of medication times can be reduced. The preparation which contains the cetirizine hydrochloride and the hydrochloric pseudoephedrine and is prepared according to the method is taken for once or twice every day.
Individuals with MS in the fourth group will be given balance exercises for 15 minutes under the supervision of a researcher physiotherapist. Exercises will be selected in accordance with the functional level of the individual and will progress according to the individual's condition. In each session, 3-5 different exercises will be performed, taking into account the functional status of the individual.
Cancer invasion and migration play a pivotal role in tumor malignancy, which is a major cause of most cancer deaths. Rotating magnetic field (RMF), one of the typical dynamic magnetic fields, can exert substantial mechanical influence on cells. However, studying the effects of RMF on cell is challenging due to its complex parameters, such as variation of magnetic field intensity and direction. Here, we developed a systematic simulation method to explore the influence of RMF on tumor invasion and migration, including a finite element method (FEM) model and a cell-based hybrid numerical model. Coupling with the data of magnetic field from FEM, the cell-based hybrid numerical model was established to simulate the tumor cell invasion and migration. This model employed partial differential equations (PDEs) and finite difference method to depict cellular activities and solve these equations in a discrete system. PDEs were used to depict cell activities, and finite difference method was used to solve the equations in discrete system. As a result, this study provides valuable insights into the potential applications of RMF in tumor treatment, and a series of in vitro experiments were performed to verify the simulation results, demonstrating the model's reliability and its capacity to predict experimental outcomes and identify pertinent factors. Furthermore, these findings shed new light on the mechanical and chemical interplay between cells and the ECM, offering new insights and providing a novel foundation for both experimental and theoretical advancements in tumor treatment by using RMF.
Pulmonary fibrosis is a debilitating lung disease marked by excessive fibrotic tissue accumulation, which significantly impairs respiratory function. Given the limitations of current therapies, there is an increasing interest in exploring traditional herbal formulations like Jie Geng Tang (JGT) for treatment. This study examines the potential of JGT and its bioactive component, quercetin, in reversing bleomycin (BLM)-induced pulmonary fibrosis in mice. We employed a BLM-induced MLE-12 cell damage model for in vitro studies and a bleomycin-induced fibrosis model in C57BL/6 mice for in vivo experiments. In vitro assessments showed that JGT significantly enhanced cell viability and reduced apoptosis in MLE-12 cells treated with BLM. These findings underscore JGT's potential for cytoprotection against fibrotic agents. In vivo, JGT was effective in modulating the expression of E-cadherin and vimentin, key markers of the epithelial-mesenchymal transition (EMT) pathway, indicating its role in mitigating EMT-associated fibrotic changes in lung tissue. Quercetin, identified through network pharmacology analysis as a potential key bioactive component of JGT, was highlighted for its role in the regulatory mechanisms underlying fibrosis progression, particularly through the modulation of the IL-17 pathway and Il6 expression. By targeting inflammatory pathways and key processes like EMT, JGT and quercetin offer a potent alternative to conventional therapies, meriting further clinical exploration to harness their full therapeutic potential in fibrotic diseases.
NEW MATERIAL:A compound expressed by formula I [R is alkyl, OH, carboxy, halogen or oxo; m is 2-7; X and Y are Cl, nitric acid radical or both together -OCOCH(R<1>)O-, -OCOCOO, formula VII or formula VIII (R<1> is H, alkyl, etc.; R<2> is H or alkyl; n is 2-5). EXAMPLE:(Ammine) (glycolate-O,O') (pyrrolidine)platinum (II) 10a, 10b. USE:An antiulcer agent having higher solubility than other platinum complex antiulcer agent. PREPARATION:For example, according to the reaction equation, a compound expressed by formula VI is reacted with KI in water to afford a compound expressed by formula V, which is then reacted with an aqueous solution of alicyclic amine expressed by the formula Am added and the resultant compound expressed by formula IV (Am is formula IX) is reacted with silver nitrate in water under light-sielding states to a compound expressed by formula III, whose aqueous solution is successively treated with an anion exchange resin to give the compound expressed by formula II. Further the above-mentioned compound is reacted with a reagent A (e.g. KCl) to provide the aimed compound.
PURPOSE: A cosmetic composition containing persimmon extract and ginseng extract is provided to ensure anti-atopy and anti-aging performance without side effect. CONSTITUTION: A cosmetic composition for anti-atopy and antiaging contains persimmon extract and ginseng extract. The persimmon extract is persimmon polyol extract or ethanol extract. The extract is stabilized with a nanoliposome. The nanoliposome is prepared by passing liposome containing phospho lipid, glutathione, 95% denaturated ethanol, glycerin, and polysorbate 20 through a high pressure emulsifier. The cosmetic composition is manufactured in the form of a lotion, gel, water soluble liquid, cream, essence, oil in water(O/W) type or water in oil(W/O) type basic cosmetic formulation, foundation, skin cover, lip stick, lip gloss, and face powder.
This study adopt a method of multicenter, open-labeled, self-paired design. Each subject will be randomly assigned to two different detective sequence groups. In one group, the investigators will detect the same calcaneus of each subject by experimental ultrasound bone strength device firstly and then by control device. In another group, the investigators will detect the same calcaneus of each subject by control ultrasound bone strength device firstly and then by experimental device. Experimental ultrasound bone strength device is developed by Wuxi Huajian Hengchuang Medical Equipment Science and Technology Co., Ltd.. This device's model number is Oste-scan 500A and report number is Z-Y-2009-2014, Z-E-0530-2014(G). Control ultrasound bone strength device which has same clinical indications and action mechanism with the experimental one, is manufactured by Osteosys Co., Ltd.. This device's model number is SONOST3000.
Toe deformities may cause prominence of the metatarsal heads (MTH) and distal displacement of fat-pad cushion beneath the MTH, resulting in the metatarsal pain. Foot pain frequently leads to limitation of activities of daily life and deterioration of life quality. Foot orthoses have been commonly used in clinical practice to reduce plantar pressure and subsequent pain. However, the therapeutic efficacies of custom molded insoles with a metatarsal support vary widely with their designs and materials. We designed a simple and effective method that a dynamic impression insole was made by sequential padding of foams with different compressibility under successive dynamic impression in daily walking. A piece of metatarsal pad and arch support made of EVA was attached to the bottom of impressed insole just proximal to the first, second, and third MTH according to the foot impression. Fifty participants with metatarsal pain were recruited from the podiatry outpatient clinic of Taipei Veteran General Hospital. The plantar pressure measurements were carried out under a comfortable and stable walking speed preferred by the participants one month after the dynamic impression and custom molded insoles were well fabricated. All pressure data were processed with the Novel-Win Multimask analysis software. The purposes of this study were to investigate the biomechanics of dynamic impression insole in plantar pressure and pain reduction.
Interventional neuroradiology procedure under general anesthesia requiring a continuous monitoring of mean arterial pressure and cardiac output, including electrocardiogram, pulsated oxygen saturation, endtidal CO2, respiratory rate, tidal volume and monitoring of neuromuscular function. In addition, for all patients, data from trans-oesophageal Doppler, trans-thoracic echocardiography (TTE) and hemodynamic data are collected at the end of the procedure. During catheter withdrawal, pressure waveforms are recorded in the descending thoracic aorta just in front of the esophageal Doppler probe.
The invention provides fluid-increasing decoction formula granules. The fluid-increasing decoction formula granules contain extracts prepared by the step of decocting radix scrophulariae, radix ophiopogonis and radix rehmanniae recen. The invention also provides a preparation method, application and a detection method of the fluid-increasing decoction formula granules. According to the fluid-increasing decoction formula granules, the defect that various herbal medicines are simply added when the conventional single-component formula granules are taken is overcome, the compatibility advantages of traditional Chinese medicine are fully exerted, the holistic thinking of traditional Chinese medicine is reflected, the aim of reducing toxicity and enhancing efficacy is ensured, the fluid-increasing decoction formula granules are quasi steady and controllable in quality and convenient to store and carry by patients, and the decoction trouble is avoided. The preparation method of the fluid-increasing decoction formula granules is simple, the herbal medicines are decocted together according to the traditional method, and the characteristics of the traditional Chinese medicine are met. According to the detection method of the fluid-increasing decoction formula granules, the perfect quality standard of the fluid-increasing decoction formula granules is established, and the quality of the formula granules can be effectively controlled.
PURPOSE:To obtain the title remedy containing an antitryptase antibody capable of specifically reacting with tryptase as an active ingredient and having action strongly suppressing infection of human immunodeficiency virus. CONSTITUTION:The antibody obtained form serum obtained by immunizing tryptase, being a trypsin type new protease, isolated and purified form human lung mast cell, intraperitoneal mast cell, etc., of rat, consisting of tetramer having about 35000 subunit and having about 140000 molecular weight to an animal. The remedy containing the above-mentioned antibody or fragment containing antigen binding site thereof, e.g. F(ab')2 fragment obtained by pepsin treatment as an active ingredient. The dose of the antibody or the fragment is preferably 50-1000mg/kg weight/day as IgG fr fragment thereof. Vaccine for AIDS patient can be prepared using the above-mentioned tryptase alone or together with adjuvant.
Early detection of colon adenomatous polyps is pivotal in reducing colon cancer risk. In this context, accurately distinguishing between adenomatous polyp subtypes, especially tubular and tubulovillous, from hyperplastic variants is crucial. This study introduces a cutting-edge computer-aided diagnosis system optimized for this task. Our system employs advanced Supervised Contrastive learning to ensure precise classification of colon histopathology images. Significantly, we have integrated the Big Transfer model, which has gained prominence for its exemplary adaptability to visual tasks in medical imaging. Our novel approach discerns between in-class and out-of-class images, thereby elevating its discriminatory power for polyp subtypes. We validated our system using two datasets: a specially curated one and the publicly accessible UniToPatho dataset. The results reveal that our model markedly surpasses traditional deep convolutional neural networks, registering classification accuracies of 87.1% and 70.3% for the custom and UniToPatho datasets, respectively. Such results emphasize the transformative potential of our model in polyp classification endeavors.
Delirium is a distressing and common surgical complication, affecting approximately 20-50% of older surgical patients. Postoperative delirium is associated with increased mortality, cognitive and functional decline, and healthcare resource utilization. Prevention programs have been tested with variable success, but the Hospital Elder Life Program (HELP) has consistently been demonstrated to reduce the incidence and impact of delirium. However, substantial resources are needed for program operations, and complementary support systems may help with patient triage and assessment. Family members and caretakers may be able to provide supplementary support with delirium screening and prevention via targeted, therapeutic activities. Thus, an automated postoperative paging system, which elicits additional, focused support from HELP and family members, may augment delirium prevention activities and reduce associated risk.

The primary objectives of this study are to determine whether pager-based clinical decision support systems bolster HELP- and family-based therapeutic activities. A secondary objective will be to identify facilitators and barriers to delivering therapeutic interventions for both HELP and family members. Overall, this pilot trial will test the hypothesis that a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical patients. Patients (n=60) will be randomized to one of four groups in a factorial design: usual care (n=15), HELP-based paging system (n=15), family-based paging system (n=15), or both HELP- and family-based paging system (n=15). The support systems will consist of automated pager alerts to the HELP program and/or family members and caretakers, depending on group allocation, for providing additional delirium evaluation and therapeutic prevention activities. Outcomes will include various clinical, neurocognitive, and functional measures, and performance metrics will be collected regarding HELP- and family-based interventions.
The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.
The HAPNeSS method would offer caregivers the opportunity to find solutions to difficulties encountered (behavioral disorders, difficult care, etc.), to move away from pure technicality to reinvest in the relationship with the patient, and to find soothing, respectful and benevolent channels of communication. The aim of this study is to evaluate the effects of HAPNeSS (Hypnosis Adapted to People with Severe Neurocognitive Disorders) training on the care of residents over 75 with moderately severe to severe Alzheimer's disease or related disorders, who may present behavioral problems.

But also to measure, within each establishment, the effects of the HAPNeSS method, on the professional practices of caregivers (actions implemented, execution of missions, relationship with residents...) and to gather their feelings. These objectives therefore aim to collect and evaluate the effects of this method on the relationship between patients and caregivers, as well as on the latter's QWL. To achieve this, the research team organized 4 visits to the EHPADs participating in the study, spread over 6 months. Training takes place over 3 and then 2 days. Before and after the training, a visit at the beginning and end of the study will enable the scales to be administered and the interviews to be conducted. The data collected will be the subject of a mixed statistical analysis. Throughout the study, the research team will monitor the learning and development of each care professional.
Over the past decade, acute kidney injury (AKI) has acquired much attention because of their potentially devastating problems in clinical medicine. When kidneys lost their filtering function, a lot of dangerous metabolites were accumulated in the body, including urea, nitrogenous waste products and uremic toxins. Indoxyl sulfate (IS) is an anionic uremic toxin that is accumulated in the serum of patients with uremia. In previous study, the investigators successfully induced AKI animal model. IS enhanced intercellular adhesion molecule-1 (ICAM-1) expression in IL-1β-treated human umbilical vein endothelial cells (HUVECs) that this may play a critical role in the progression of AKI. However, the molecular mechanisms of ICAM-1 expression in IS-treated IL-1β-treated HUVECs need to be elucidated. HUVECs incubated with 0.2 or 1 mM IS for 24 h did not cause cytotoxicity. The IL-1β-induced ICAM-1 expression in HUVECs was significantly enhanced by IS pretreatment. Furthermore, the regulation of adhesion molecule expression involves a complex array of intracellular signaling pathways including mitogen-activated protein kinase (MAPKs), reactive oxygen species (ROS) and transcriptional factors. A better understanding of this might provide important insights into the prevention of AKI.
Subjects with heart failure with preserved ejection fraction will receive 140 mL of Nitrate-rich concentrated beetroot juice (containing 12 mmol of NO-3). This will be a cross-over study. Therefore all subjects will receive both interventions, but the order of the interventions will be randomized.
One of the many unresolved obstacles in the field of cardiovascular research is an uncompromising in vitro cardiac model. While primary cell sources from animal models offer both advantages and disadvantages, efforts over the past half-century have aimed to reduce their use. Additionally, obtaining a sufficient quantity of human primary cardiomyocytes faces ethical and legal challenges. As the practically unlimited source of human cardiomyocytes from induced pluripotent stem cells (hiPSC-CM) is now mostly resolved, there are great efforts to improve their quality and applicability by overcoming their intrinsic limitations. The greatest bottleneck in the field is the in vitro ageing of hiPSC-CMs to reach a maturity status that closely resembles that of the adult heart, thereby allowing for more appropriate drug developmental procedures as there is a clear correlation between ageing and developing cardiovascular diseases. Here, we review the current state-of-the-art techniques in the most realistic heart models used in disease modelling and toxicity evaluations from hiPSC-CM maturation through heart-on-a-chip platforms and in silico models to the in vitro models of certain cardiovascular diseases.