anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
As the proportion of prime carcasses originating from dairy herds increases, the focus is shifting to the beef merit of the progeny from dairy herds. Several dairy cow total merit indexes include a negative weight on measures of cow size. However, there is a lack of knowledge on the effect of genetic selection, solely for lighter or smaller-sized dairy cows, on the beef performance of their progeny. Therefore, the objective of this study was to quantify the genetic correlations among cow size traits (i.e., cow BW, cow carcass weight [CW]), cow BCS, cow carcass conformation (CC), and cow carcass fat cover (CF), as well as the correlations between these cow traits and a series of beef performance slaughter-related traits (i.e., CW, CC, CF, and age at slaughter [AS]) in their progeny. After data editing, there were 52,950 cow BW and BCS records, along with 57,509 cow carcass traits (i.e., CW, CC, and CF); carcass records from 346,350 prime animals along with AS records from 316,073 prime animals were also used. Heritability estimates ranged from moderate to high (0.18-0.62) for all cow and prime animal traits. The same carcass trait in cows and prime animals were strongly genetically correlated with each other (0.76-0.85), implying that they are influenced by very similar genomic variants. Selecting exclusively for cows with higher BCS (i.e., fatter) will, on average, produce more conformed prime animal carcasses, owing to a moderate genetic correlation (0.30) between both traits. Genetic correlations revealed that selecting exclusively for lighter BW or CW cows will, on average, result in lighter prime animal carcasses of poor CC, while also delaying slaughter age. Nonetheless, selective breeding through total merit indexes should be successful in breeding for smaller dairy cows and desirable prime animal carcass traits concurrently, because of the nonunity genetic correlations between the cow and prime animal traits; this will help to achieve a more ethical, environmentally sustainable, and economically viable dairy-beef industry.
Continuous wound infusion device used in this study was ON-Q Painbuster Silver Soaker (I-Flow Corporation, Lake Forest, CA, USA) comprised an elastomeric pump maintaining constant pressure to infuse 2ml/hour of analgesic to the wound through a catheter for 50 hours. In all participants, the surgeon inserted a 20-gauge, 6.5-cm, multi-holed soaker catheter through an introducer needle after closure of the transumbilical fascia. The catheter was located in the deep subcutaneous space, above the fascia near the skin incision. In the experimental group, an elastomeric pump filled with local analgesic solution (total volume 100ml) containing 750mg ropivacaine .
BACKGROUND: Madelung's deformity is a congenital or acquired growth disorder of the forearm that can lead to significant impairments in the quality of life of affected patients. Various surgical treatment options for the condition have been described in the literature. This study aimed to investigate whether physiolysis with resection of the Vickers ligament can successfully halt the progression of the disease in a cohort of young patients, as would be expected based on existing literature on this topic.
MATERIAL AND METHODS: An analysis was performed on the records of all patients with Madelung's deformity who were primarily treated with physiolysis with resection of the Vickers ligament between January 2001 and June 2017. Patients were invited for follow-up examinations, and surgical outcome was assessed. Parameters evaluated included pain at rest and under load, range of motion of the wrists, and activity level. Additionally, standard X-rays and radiological measurements were performed for each operated wrist. The collected data was compared with the preoperative data from patient records.
RESULTS: Nine wrists were included in the study. The average age at the time of surgery was 13.2 years, and the average follow-up period was five years. Extension and ulnar abduction showed a slight decrease from preoperative to follow-up, while flexion improved minimally, and radial abduction and forearm rotation showed noticeable improvement. The visual analogue scale score for pain at rest increased from preoperative 0.25 points to 1.88 points at follow-up. Under load, the average pain score increased from 2.00 to 4.25 points. The mean DASH score increased from 6.04 points before the surgical procedure to 12.20 points at follow-up. The average values of two out of the five measured McCarroll parameters increased, the increase being statistically significant for lunate subsidence. A follow-up procedure was required in one wrist.
CONCLUSION: In our cohort, the progression of Madelung's deformity was only partially halted by physiolysis with resection of the Vickers ligament, and a significant increase in pain symptoms during the study period could not be avoided. Therefore, this procedure should be used cautiously in skeletally immature patients.
This study plans to use 1.0×108PFU/day per cycle, intratumoral injection administration for 3 consecutive days, and 28 days as a cycle. Tumor imaging evaluation was performed every 8±1 weeks from the first dose of C1D1 until an event that met the criteria for treatment discontinuation occurred. If the subject VG161 injection target lesion shrinks after treatment and can no longer receive intratumoral injection administration of this administered dose of VG161, after evaluation by the investigator, it is allowed to reduce the dosing dose or suspend the administration as appropriate according to the size of the injectable lesion. After the end of treatment, there will also be an end-of-treatment visit and a post-treatment safety visit. Subjects who end the study for reasons not attributable to disease progression will undergo imaging evaluation at the end of treatment (if no imaging evaluation is performed within 4 weeks) and have imaging every 3 months after the end of treatment until disease progression or death or initiation of new anti-tumor therapy (whichever occurs first) to assess the time to disease progression. After the end of treatment, the subjects will also receive survival follow-up once every 3 months, and the survival status of the subjects and subsequent anti-tumor therapy will be collected and recorded until death, loss to follow-up or 1 year after the last dose (whichever occurs first).
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology and radiation diagnostics, and can be used for assessing the effectiveness of chemotherapy for malignant lymphomas. One-photon emission computed tomography (OPECT) is performed twice: before and two weeks after completion of chemotherapy in patients with initially high accumulation of radiopharmaceutical (RP) in the tumor. That is ensured by administering a radiopharmaceutical preparation based on technetium-99m-labeled glucose derivative prepared immediately before administration. For this purpose 4 ml of sodium pertechnetate NaTcOfrom a generator under aseptic conditions is introduced by means of a syringe into a bottle with a reagent consisting of: 1-thio-D-glucose sodium salt of hydrate 0.625 mg, tin dichloride 2-water 0.044–0.052 mg, ascorbic acid not more than 0.125 mg, sodium chloride 8.0–10.0 mg, water for injection up to 1 ml. Content of the vial is mixed by shaking, incubated at room temperature for 30 minutes until complete dissolution of the reagent. Intravenous is administered RP in dose of 500 MBq. In 40 minutes after administration RP one-photon emission computed tomography is carried out on a two-detector gamma camera. Obtained images are subjected to postprocessing. In the absence of hyperfixation foci RP repeated reassessment involves complete remission of malignant lymphoma. Presence of hyperfixation areas RP in tissue of lymph nodes and extranodally indicates resistance of malignant lymphoma to chemotherapy.EFFECT: high information value and accessibility of the method.1 cl, 2 dwg, 2 ex
The invention relates to impression compositions based on vulcanizable polyether materials, which are characterized in that the ready-mixed pastes comprise a) approx. 30 to 70 wt. % of aziridino-polyether, b) approx. 5 to 20 wt. % of a triacyl glyceride of non-animal origin which has a stearoyl content of >/=70 wt. %, based on the acyl content of the triacyl glyceride, or, in the case of a lower stearoyl content and if this adversely influences the storage stability of the impression composition, has been esterified in itself beforehand, and c) approx. 10 to 65 wt. % of customary catalysts, auxiliaries and additives, in each case based on the total weight of the composition. The impression compositions are distinguished by consistently good mechanical properties of the polymerized materials, have a comparatively low proportion of aziridino-polyether, which has a favourable effect on their preparation costs, and can easily be mixed. During storage of the compositions over long periods of time, no noticeable increase in viscosity occurs, even at elevated temperatures.
The invention discloses a cetuximab mutant and application thereof. The amino acid sequence of the heavy chain variable region of the cetuximab mutant is shown in any one of SEQ ID No. 1-6. The Cetuximab mutant with the amino acid sequence of the heavy chain variable region of the antibody shown in SEQ ID No.1-5 is effective to EGFR S492R, and the Cetuximab mutant with the amino acid sequence of the heavy chain variable region of the antibody shown in SEQ ID No.1 and 2 has better effect than Panitumumab. The Cetuximab mutant with the amino acid sequence of the heavy chain variable region of the antibody shown in SEQ ID NO.6 is effective to EGFR G465R and has obvious effect. The Cetuximab mutant of the amino acid sequence of the heavy chain variable region of the antibody obtained by the invention is shown in SEQ ID NO.1, 2 and 6, and still maintains the affinity to the wild type EGFR.
The invention discloses a pharmaceutical composition, and a preparation method, preparation and application thereof. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 200-400 parts of Yushu, 800-1200 parts of Tinospora crispa, 800-1200 parts of belamcanda rhizome, 225-450 parts of curcuma, 225-450 parts of Rhizoma Zedoariae, 225-450 parts of curious kadsura root or stem, 100-300 parts of pepper and 200-400 parts of dried ginger. The preparation method comprises the following steps: respectively extracting, concentrating and drying to obtain the pharmaceutical composition. Pharmaceutically acceptable adjuvants can be added into the pharmaceutical composition to prepare powder, tablets, capsules, granules, dripping pills or honeyed pills. The invention also relates to application of the pharmaceutical composition for treating limpness, numbness and crymodynia of limb joints. The Yushu used as the main drug has the effects of tonifying fire, strengthening the body, eliminating wind, promoting blood circulation, alleviating pains, promoting the subsidence of swelling and dissipating blood stasis; the dried ginger and pepper used as the adjuvants promote the main drug to enhance the curative effect; the curcuma, Rhizoma Zedoariae and curious kadsura root or stem has the effects of activating blood circulation to dissipate blood stasis and inducing menstruation to relieve menalgia; and the Tinospora crispa and belamcanda rhizome replenish water for moistening, replenish essence and tonify the marrow. The combination of the whole formula can treat limpness, numbness and crymodynia of limb joints.
Multi-layer reaction mixtures that includes exothermic generating particles having a water soluble coating encasing a portion of the particles, a volatile component and, optionally, a buffer, an aqueous solution or both. At least two layers of the reaction mixture contain exothermic generating particles and at least one layer of the reaction mixture contains a portion of the exothermic generating particles suspended in a gel that includes the water soluble coating. These multi-layer reaction mixtures are especially suited to generate heat in a controllable manner. In one such controlled reaction, the reaction components are mixed together and the reaction mixture increases in temperature to a Set Temperature within a predetermined time, and the mixture remains at the Set Temperature for a longer period of time. In this manner, volatile components can be controllably released to the surrounding environment. The volatile components can be, for example, a perfume, a fragrance, an insect repellent, a fumigant, a disinfectant, a bactericide, an insecticide, a pesticide, a germicide, an acaricide, a sterilizer, a deodorizer, a fogging agent and mixtures of these. Apparatuses and methods that use these multi-layer reaction mixtures are also disclosed.
This study aims to investigate the factors affecting the stone-free rate (SFR) of flexible ureteroscopy and laser lithotripsy (fURSL) for renal stones and establish predictive models by identifying their prognostic factors. We retrospectively examined 252 patients with renal stones who were treated with fURSL between July 2020 and April 2022. We analyzed the relationship between the patient's clinical data (sex, age, and body mass index), stone status (side, size, location, stone/transverse process pixel ratio [STPR], and the CT value of stone [SCTV]), and SFR to determine the relevant factors and analyze their influence. Additionally, a nomogram was constructed based on these prediction results. A total of 252 patients were enrolled based on the inclusion and exclusion criteria. They were reviewed 7, 30, and 90 days postoperatively, with 46, 23, and 10 patients failing to discharge stones, respectively. Univariate Cox proportional hazard regression results revealed that the SFR was correlated with stone location, diameter (D1, diameter of stone measured by computed tomography [CT]; D2, diameter of stone measured by kidney-ureter-bladder abdominal radiography), SCTV, STPR, and operation time. Multivariate Cox proportional hazard regression was used to develop 2 predictive models for the SFR. The influencing factors of model 1 included D1, location, and SCTV, whereas those of model 2 were D2, location, and STPR. The results are shown in the nomogram. Receiver operating characteristic curves showed no significant difference between models 1 and 2 (P = .498), indicating that the nomogram was highly predictive. After 1000 resamples and internal self-validation, the C-indices of models 1 and 2 were 0.924 and 0.895, respectively, showing that the stone clearance predicted by the nomogram matched the actual situation. Stone location, size, and density (SCTV and STPR) were significant predictors of SFR after fURSL. The scoring system based on these factors may be used to guide optimal treatment strategy selection.
PURPOSE:To obtain the titled drug preparation, by dialyzing urine of healthy person with running water and distilled water, artificially drying in air to attain a prescribed sugar protein concentration and adding a proper amount of the product to a liquid or ointment, etc., such as water, alcohol or saline water. CONSTITUTION:The titled drug preparation is produced by dialyzing urine of a healthy person (having a pH of about 6.5) with running water for 48hr and then with distilled water for 24hr, artificially drying the dialysis product in air to adjust the sugar protein concentration to 1,000mg/dl and mixing the dried product into a base such as liquid or ointment (e.g. water, alcohol or saline water) at a concentration of 100mg/100g. The drug is extremely effective against dermatic and mucomembranous diseases supposed to be caused by an autoantigen-antibody reaction with an atypical antibody. The urine used as a starting raw material is preferably obtained from a male adult of 10-35 years old. Urine negative to sulfo test is collected in early morning, put into a sterilized cellophane membrane bag, dialyzed with running water and stored in frozen state. It is used after filtration under pressure and sterilization treatment.
Dental caries is a major public health problem. It has been estimated that 621 million children in the world have untreated dental caries . Dental caries always manifests with significant pain, affecting oral health-related quality of life (OHRQoL) and well-being. Several measures were widely used to comprehensively evaluate the effect of oral diseases and disorders on children's OHRQoL. However, most of these measures were 'generic' measures, and they may fail to detect small, clinically important changes related to specific oral diseases. Gilchrist et al recently developed the Caries Impacts and Experiences Questionnaire for Children (CARIES-QC) in order to address this issue. Preliminary findings have confirmed that Caries Impacts and Experiences Questionnaire for Children measure had good reliability, validity, and responsiveness. However, The original CARIES-QC was an English measure; so appropriate translation and cultural adaptation should be done in order to be used in other culture and language.

Arabic is one of the most spoken languages in the world; however, the CARIES-QC has not yet been validated in Arabic speaking children. So the purpose of this study was to translate the CARIES-QC into Arabic and test the measurement properties of the Arabic version of the CARIES-QC for use in children with dental caries who speaks Arabic .
Most of the studies published so far about lumbar fusion surgery have been interested in surgical procedure itself or in comparison of conservative or operative treatment. Less information is available about long-term outcome and exercise programs for operated patients. Therefore the investigators have developed "Spine fusion register", which include data on surgery procedure and outcome (pain, disability, back muscle function, quality of life, working capacity, reoperations and complications etc.) before and after surgery up to 5 years (started in January 1st, 2008). The main purpose of the present study is to analyze the significance of 12-month strength and aerobic training for outcome of the lumbar fusion patients compared to usual care. Patients (N=100) with lumbar fusion because of isthmic or degenerative olisthesis will be will be stratified by catchments area and randomized into combined strength and aerobic training group or into the control group.
PURPOSE:To provide a preparation such as a suppository comprising cyclodextrin and polyacrylic acid, sufficiently staying at an administered site or an inserted site such as rectum, and excellent in the sustained release property of a medicine. CONSTITUTION:The preparation comprises cyclodextrin and polyacrylic acid (preferably having a number-average mol.wt. of 1000-10000000). 100 pts.wt. of the cyclodextrin is preferably compounded with 150-1000 pts.wt. of the polyacrylic acid. The preparation is preferably obtained by a method in which the cyclodextrin is kneaded with a medicine and another base material, or a method in which the polyacrylic acid is kneaded with the cyclodextrin, a medicine, another base material and water or various kinds of aqueous solutions and, if necessary, subsequently dried. The medicine to be added to the preparation is a medicine easily adsorbed on or included in the cyclodextrin, such as 5-FU or tegafur.
The placement of cervical cerclage is standard of care for women who experience incompetent cervix. Treadwell et al, published the largest retrospective review of 482 patients receiving cerclage (364 elective and 118 emergent). They found premature rupture of membranes (PROM) in 38% of the subjects with 9% delivering \<27 weeks. Preterm birth is the cause of at least 75% of neonatal deaths that are not due to congenital malformations. The question of whether to remove cerclage after preterm premature rupture of membranes (PPROM) is one of the unresolved controversies in obstetrics because the few available studies are retrospective, all have small numbers of patients, and the studies have given conflicting results regarding the safety of retaining a cerclage after preterm premature rupture of the membranes. It is unclear from the retrospective studies whether latency (the interval from membrane rupture to the onset of labor) is prolonged with retention of the suture. Furthermore, some, but not all studies suggest an increase in major infectious maternal morbidity and possibly neonatal morbidity. For this reason, clinicians vary greatly in deciding on whether to remove a cerclage in a patient with PPROM and either practice is currently an acceptable standard. This is a fairly rare complication, the combination of PPROM in a patient with cerclage in place only occurs in about 1-3/1000 pregnant women. Thus it has been impossible to study this problem prospectively in any single institution. The establishment of the Obstetrix Collaborative Research Group affords the unique opportunity to study this rare complication. Obstetrix manages 19 practices of Perinatologists around the U.S. and Mexico and is comprised of nearly 100 such subspecialists. This problem is most often referred to a Perinatologist when it occurs, so it is not unusual for these practices to see 5 - 10 such patients per year. Obstetrix fully funds the infrastructure of this research group and inclusion in this study will not alter the cost of patient care in either group as there is virtually no cost in removing the cerclage and all these patients are kept in hospital until delivery when membranes rupture as standard of care.

This is a multicenter trial. The purpose is to determine whether retention of cerclage after preterm premature rupture of the membranes improves latency (without a significant increase in chorioamnionitis) and lessens neonatal morbidity.
In active comparator group, n= 44 study participants will be enrolled. Pre-formed metal crowns will be selected according to the tooth size and filled with low viscosity glass ionomer cement and seated using digital/ finger pressure.