anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Loss of walking ability is a one of the major problem after stroke and recovery of walking is a priority goal for most patients. Several studies demonstrated that rehabilitation could be an effective treatment on improving gait following stroke. Learning to walk backwards correctly has been recommended to improve the movement components required for walking forwards. Backward walking, therefore, has been promoted as a treatment strategy to improve gait. During backward walking the same motor programme is used as during forward walking, but possibly running in reverse. It has been suggested that backward walking may offer some benefits beyond those experienced through forward walking alone. Backward walking appears to create more muscle activity in proportion to effort than forward walking. This suggests a greater level of energy expenditure in backward walking than in forward walking. Additionally, backward walking also demands a greater oxygen consumption, metabolic response and cardiorespiratory than forward walking. Up to our knowledge, only two studies demonstrated the positive effects of an additional backward walking training in post stroke patients. Yang and coll. examined the effectiveness of additional backward walking training on gait outcome of 25 subacute stroke patients and they demonstrated that asymmetric gait pattern could improve. In a recently study, a randomized control trail was conducted on 36 acute stroke patients evaluating the efficacy of a walk backwards on a treadmill. The patients were randomly allocated to three groups and they received 3 weeks of intervention: first group (n=12) underwent partial body weight support treadmill training in backwards, the second group (n=12) received partial body weight support treadmill training and the third group underwent conventional rehabilitation training. The results showed significant improvements in walking speed and in the rivermead Mobility Index, suggesting that Partial Body Weight Support treadmill backward training for patients in the early phase of acute stroke is effective at improving mobility.

Recently, gait rehabilitation methods in patients with neurological impairment have relied on technological devices, which drive the patient's gait in a body-weight support condition and emphasize the beneficial role of repetitive practice. The rationale for these approaches originates from animal studies which have shown that repetition of gait movements may enhance spinal and supraspinal locomotor circuits.

Two reviews concludes that treadmill training with partial body weight support is effective to improve walking speed and endurance without worsening gait quality
Photodynamic therapy (PDT), as a means of locally and rapidly inducing adipocyte death via light illumination, in combination with adipose browning induction, a more gradual and widespread effect that could transform white adipose tissue into thermogenic adipose tissue, manifests a promising approach to combat obesity. Herein, adipose-targeting ultra-small hybrid nanoparticles (Pep-PPIX-Baic NPs) composed of an adipose-targeting peptide, Fe3+, a photosensitizer (protoporphyrin IX), and a browning agent (baicalin) are introduced. Pep-PPIX-Baic NPs have been designed to simultaneously enhance the photodynamic effect and induce browning. After intravenous injection in obese mice, the hybrid nanoparticles can specifically accumulate in white adipose tissues, especially those rich in blood supply, and drive adipose reduction owing to the synergy of the PDT effect and baicalin browning induction. Overall, Pep-PPIX-Baic NPs exhibited superior anti-obesity potential through PDT synergistic with adipose browning induction. The designed multifunctional adipose-targeting hybrid nanoparticles present a prospective nanoplatform for obesity treatment.
OBJECTIVES: Subarachnoid haemorrhage (SAH) carries a high burden of morbidity and mortality. One in three patients develop vasospasm, which is associated with Delayed Cerebral Ischemia. The pathophysiology includes vasoconstrictor receptor upregulation in cerebral arteries. The protein kinase C - inhibitor RO-31-7549 reduces the expression of several vasoconstrictor receptors and normalizes cerebral blood flow in experimental SAH but functional and behavioural effects are unknown. This study was undertaken to analyse functional outcomes up to 14 days after experimental SAH.
MATERIALS AND METHODS: 54 male rats were randomised to experimental SAH or sham, using the pre-chiasmatic, single injection model, and subsequent treatment or vehicle. 42 remained for final analysis. The animals were euthanized on day 14 or when reaching a humane endpoint. The primary endpoint was overall survival, defined as either spontaneous mortality or when reaching a predefined humane endpoint. The secondary outcomes were differences in the rotating pole test, weight, open field test, novel object recognition and qPCR of selected inflammatory markers.
RESULTS: In the vehicle group 6/15 rats reached the humane endpoint of >20 % weight loss compared to 1/14 in the treatment group. This resulted in a significant reduced risk of early euthanasia due to >20 % weight loss of HR 0.15 (0.03-0.66, p = 0.04). Furthermore, the treatment group did significantly better on the rotating pole test, RR 0.64 (0.47-0.91, p = 0.02).
CONCLUSION: RO-31-7549 improved outcomes in terms >20 % weight loss and rotating pole performance after experimental SAH and could be investigated.
An optical physiological signal sensor and a health monitoring device are provided. The optical physiological signal sensor includes a module substrate, a light emitting module, and a detecting module. The module substrate includes a substrate, an electrode group, and a conductive path. The substrate has an emitting area, a receiving area, and an organism contacting area between the emitting area and the receiving area. The electrode group is disposed on the organism contacting area and includes a first sensing electrode, a second sensing electrode, and a grounding electrode. The conductive path is configured to allow for electrical conduction between the first sensing electrode and the second sensing electrode. The light emitting module is disposed on the emitting area and includes at least one light 
emitting unit and a first packaging layer covering the at least one light emitting unit. The detecting module is disposed on the emitting area and includes at least one detecting unit and a second packaging layer covering the at least one detecting unit.
The present invention relates to a biocellulose having reinforced tensile strength, and to a method for producing the same. More specifically, the present invention relates to a culture medium additive for culturing a biocellulose production strain, in which beans for reinforcing biocellulose tensile strength are contained; a culture medium containing the culture medium additive; a biocellulose produced by a biocellulose production strain in the culture medium and having tensile strength reinforced by 1.5 times; and a method for producing the biocellulose. When the method for producing the biocellulose is used, time in producing a biocellulose is reduced, and a biocellulose produced through the method has reinforced tensile strength compared to a conventional biocellulose. When the biocellulose of the present invention is produced into the shape of a mask pack sheet, a product can be produced although a fine operation is not performed. Also, when the mask pack sheet is used, the mask pack is not easily broken and can be conveniently used. Moreover, the biocellulose produced through the method of the present invention has high moisture retentivity, thereby having an excellent moisturizing effect.
Phyto-based treatments for anxiety and depression are gaining attention. The efficacy of the water-soluble Moringa oleifera seed lectin (WSMoL) in reducing acute anxiolytic and depressive-like behaviors in mice has been previously demonstrated. In the present study, it was evaluated the effects of WSMoL on reducing anxiety and depressive-like symptoms in a mouse model of unpredictable chronic mild stress (UCMS). The animals were divided into groups and exposed to a four-week UCMS regimen. Following this, the mice received daily intraperitoneal injections of vehicle (non-stressed and UCMS control groups), WSMoL (2 or 4 mg/kg), or fluoxetine (10 mg/kg) for 21 days. Neurobehavioral tests included the open field test and elevated plus maze test to assess anxiety-like behavior, and the tail suspension test and sucrose preference test to evaluate depression-like behavior. Biochemical analyses measured serum corticosterone and cytokines as well brain levels of cytokines and monoamines. All tests indicated that WSMoL significantly (p < 0.05) reversed the anxiety and depression-like behaviors induced by UCMS. The stress protocol increased serum corticosterone levels and WSMoL treatment was not able to normalize corticosterone secretion. WSMoL treatment reduced serum and brain levels of IL-2, IL-6, and TNF-α, indicating reduced neuroinflammation, and increased brain levels of dopamine, serotonin, and noradrenaline. In summary, WSMoL mitigated UCMS-induced anxiety and depression-like behaviors by reducing neuroinflammation and modulating brain monoamine levels.
Introductory Statement: Our laboratory has found that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have insufficient levels of vitamin D3. This is a proposal to conduct a placebo controlled trial on the use of vitamin D3 (5,000IU/day for 6 weeks) to determine clinical and immunologic outcomes in these patients.

General Investigational Plan: We routinely examine vitamin D levels in all patients with CRSwNP. Those that are insufficient (less than 32 ng/ml) and have agreed to undergo sinus surgery will be randomized to placebo or vitamin D3 supplementation (5,000IU/day) for 6 weeks prior to surgery. Blood will be drawn pre- and post-supplementation to examine systemic immune parameters such as dendritic cell and T cell expression and cytokine levels. Sinus tissue will be collected at the time of surgery to analyze local immune parameters (dendritic cell, T cell and cytokine levels) between supplemented and placebo groups. Clinical outcomes will be analyzed using quality of life questionnaires, endoscopic grading and nasal peak inspiratory flow pre- and post- supplementation. IRB approval for this research project is pending.
The invention relates to biophosphate ceramic materials for medicine, more specifically for traumatology, orthopedics, reconstructive surgery, cosmetology and dentistry, and to a drug delivery system. The porous microspheres are granules based on calcium phosphate, obtained from biological hydroxyapatite, and magnesium orthophosphate. The mixture from which the granules are formed by electrospinning also contains 1-3% sodium alginate solution in distilled water, and a curing agent, namely a saturated solution of calcium chloride. The granules are heat treated. The granules have a size within the range of from 10 μm to 1000 μm and exhibit biocompatibility, biodegradability and osteoinductive and osteoconductive properties. The granules have through pores with a size of 1-100 μm and have a total porosity of 40-75%.
CD23 is a low affinity receptor for IgE. The extracellular part of this molecule has been linked to a modified leucine zipper. This results in a trimeric configuration, since the stalk region of the CD23 molecule is itself a weak leucine zipper. This chimeric protein, designated LZ-CD23, interacts with IgE in a much stronger fashion than either simply the extracellular domain alone or the intact membrane CD23. This is the result of an increased avidity due to the stable trimeric configuration. The chimera has approximately at 10,000 fold increased ability to block IgE binding to mast cell/basophils, compared to native soluble CD23. At approximately equal concentrations to added IgE, 80% inhibition of IgE binding to Fc+531 RI on mast cells was obtained. Thus, the LZ-CD23 chimera provides a new means for blocking and binding which provides benefits in the treatment of IgE-mediated asthma and allergic diseases.
The control group treatment will consist of a daily one-hour session of 30 minutes of task-oriented training (TOT) and 30 minutes of robotic-assisted therapy (RAT), for 5 days per week, to which the repetitive Transcranial Magnetic Stimulation (rTMS) placebo treatment will be added. To achieve the placebo, the localisation of the area to be stimulated will be carried out but the coil will be placed in a vertical position so the current wil not go through the skull and the patient will just feel the vibration, communicating to the participant that it is likely that during the stimulation process he/she will not feel anything.
Provided is a method for producing a cartilage cell not undergoing hypertrophic differentiation and a cartilage cell sheet not undergoing hypertrophic differentiation which are to be used for repairing a damaged cartilage site due to, for example, arthrosis deformans.  Also provided are a cartilage cell sheet which can promote cartilage regeneration and a method for producing the same.  Also provided is an agent which promotes cartilage regeneration. It is found out that dedifferentiated cartilage cells can be redifferentiated by administering a compound represented as a thienoindazole derivative (hereinafter abbreviated as TM) to the dedifferentiated cartilage cells or undifferentiated mesenchymal cells.  Also, it is found out that TM induces the initial differentiation of a cartilage and does not promote the hypertrophic differentiation of cartilage cells.  Moreover, it is found out that TM enhances the expression of type 2 collagen that is a cartilage differentiation marker.
The invention provides a method for constructing a digital twin zebra fish nervous system based on a calcium wave imaging signal, which comprises the following steps: step 1, estimating probability distribution of neuron connection between different brain areas of zebra fish based on experimental data, and generating a network connection structure. And 2, calculating a neuron excitation inhibition index based on the zebra fish calcium wave imaging signal to obtain neuron type information. And 3, constructing a zebra fish neural network model based on the connection data and the neuron type information, and defining parameters needing assimilation. And 4, assimilating the parameters needing assimilation by using the cluster Kalman filtering until the correlation between the calcium wave data generated by the system and the experimental data is high enough. And 5, performing simulation test by using the assimilated system parameters, and repeating the step 4 if the correlation between the calcium wave signals generated by the system and the experimental data is weak until the conditions in the step 4 are met. And 6, taking the iterated assimilation parameters as system parameters to complete the construction of the zebra fish neuron system.
Depression is among the main causes of disability, and its protracted manifestations could make it even harder to treat metabolic diseases. Obesity is linked to episodes of depression, which is closely correlated to abdominal adiposity and impaired food quality. The present review is aimed at studying possible links between obesity and depression along with targets to disrupt it. Research output in Pubmed and Scopus were referred for writing this manuscript. Obesity and depression are related, with the greater propensity of depressed people to gain weight, resulting in poor dietary decisions and a sedentary lifestyle. Adipokines, which include adiponectin, resistin, and leptin are secretory products of the adipose tissue. These adipokines are now being studied to learn more about the connection underlying obesity and depression. Ghrelin, a gut hormone, controls both obesity and depression. Additionally, elevated ghrelin levels result in anxiolytic and antidepressant-like effects. The gut microbiota influences the metabolic functionalities of a person, like caloric processing from indigestible nutritional compounds and storage in fatty tissue, that exposes an individual to obesity, and gut microorganisms might connect to the CNS through interconnecting pathways, including neurological, endocrine, and immunological signalling systems. The alteration of brain activity caused by gut bacteria has been related to depressive episodes. Monoamines, including dopamine, serotonin, and norepinephrine, have been widely believed to have a function in emotions and appetite control. Emotional signals stimulate arcuate neurons in the hypothalamus that are directly implicated in mood regulation and eating. The peptide hormone GLP-1(glucagon-like peptide- 1) seems to have a beneficial role as a medical regulator of defective neuroinflammation, neurogenesis, synaptic dysfunction, and neurotransmitter secretion discrepancy in the depressive brain. The gut microbiota might have its action in mood and cognition regulation, in addition to its traditional involvement in GI function regulation. This review addressed the concept that obesity-related low-grade mild inflammation in the brain contributes to chronic depression and cognitive impairments.
The invention relates to a traditional Chinese medicine composition for treating lumbar disc herniation sciatica and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 2 parts of aconite tip, 2 parts of arisaema tuber, 1 part of realgar, 1.5 parts of camphor, 1.5 parts of clove, 1.5 parts of dried ginger and 1.5 parts of evodia. The invention also comprises the application of the traditional Chinese medicine composition in preparing a medicine for treating lumbar disc herniation sciatica. Its advantages are: 1. the selected raw material medicines accord with the compatibility principle of 'monarch, minister, assistant and guide' and have the advantages of good curative effect on treating the lumbar disc herniation sciatica and good curative effect on improving leg and waist pain. 2. The invention obtains the optimal proportion among the raw material medicines through experimental screening, and has good treatment effect. 3. The raw material medicine has no toxic or side effect, and the preparation method is simple and convenient, so that a new treatment scheme is provided for patients with lumbar disc herniation sciatica, and the practicability is strong.
BACKGROUND: Obstructive lung disease (OLD) is increasingly prevalent among persons living with HIV (PLWH). However, the role of proteases in HIV-associated OLD remains unclear.
METHODS: We combined proteomics and peptidomics to comprehensively characterize protease activities. We combined mass spectrometry (MS) analysis on bronchoalveolar lavage fluid (BALF) peptides and proteins from PLWH with OLD (n = 25) and without OLD (n = 26) with a targeted Somascan aptamer-based proteomic approach to quantify individual proteases and assess their correlation with lung function. Endogenous peptidomics mapped peptides to native proteins to identify substrates of protease activity. Using the MEROPS database, we identified candidate proteases linked to peptide generation based on binding site affinities which were assessed via z-scores. We used t-tests to compare average forced expiratory volume in 1 s per predicted value (FEV1pp) between samples with and without detection of each cleaved protein and adjusted for multiple comparisons by controlling the false discovery rate (FDR).
FINDINGS: We identified 101 proteases, of which 95 had functional network associations and 22 correlated with FEV1pp. These included cathepsins, metalloproteinases (MMP), caspases and neutrophil elastase. We discovered 31 proteins subject to proteolytic cleavage that associate with FEV1pp, with the top pathways involved in small ubiquitin-like modifier mediated modification (SUMOylation). Proteases linked to protein cleavage included neutrophil elastase, granzyme, and cathepsin D.
INTERPRETATIONS: In HIV-associated OLD, a significant number of proteases are up-regulated, many of which are involved in protein degradation. These proteases degrade proteins involved in cell cycle and protein stability, thereby disrupting critical biological functions.
Intravenous infusion of saline at a rate of 1.65 ml/kg BW and hour commencing at or up to 20 minutes before the release of aortic cross-clamp. The infusion is continued for two hours after declamping the aorta after which an additional 50 ml is given at a halved infusion rate.
Malnutrition is a critical concern among children living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), particularly in regions heavily affected by the HIV epidemic, such as sub-Saharan Africa. In 2019, nearly 2.84 million children under 19 years of age were living with HIV globally, with over 90% residing in sub-Saharan Africa. Concurrently, malnutrition remains prevalent in the region, with approximately 49 million children under the age of 5 experiencing stunting and 149 million suffering from wasting in 2018. This burden of malnutrition is exacerbated by factors such as poverty, food insecurity, and HIV/AIDS, which collectively contribute to adverse health outcomes among affected children. The bidirectional relationship between HIV/AIDS and malnutrition is well-established, with HIV infection increasing the risk of malnutrition and malnutrition worsening the progression of HIV/AIDS. Studies have consistently demonstrated higher rates of stunting, underweight, and wasting among HIV-infected children compared to their uninfected counterparts. Moreover, malnutrition significantly impacts the disease progression, morbidity, and mortality of HIV-infected individuals, further underscoring the importance of addressing this issue in pediatric HIV care. A total of 99 HIV-infected children, aged 2 to 16 years, were consecutively recruited from the pediatric infectious disease clinic of the Federal University Teaching Hospital Owerri. Anthropometric measurements, including weight and height, were obtained using a stadiometer (RGZ-160 England). Weight status was categorized as normal, underweight, overweight, or obese, while height status was classified as stunted, normal, or tall stature. The study participants ranged in age from 2 to 16 years. Approximately 20.2% of the children were underweight, and 6.1% were classified as obese. Stunting was observed in 29.3% of the participants. Notably, all forms of malnutrition, including underweight and overweight, were more prevalent among children residing in rural areas. In addition, stunting was more common among rural dwellers. This study highlights the high prevalence of malnutrition among HIV-infected children attending the pediatric infectious disease clinic at the Federal University Teaching Hospital Owerri. The findings underscore the urgent need for targeted nutritional interventions, particularly in rural areas, to improve the health outcomes of HIV-infected children.