anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among females of reproductive age. The main manifestations of this syndrome are ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology. Noticeably, PCOS is associated with several metabolic disturbances such as insulin resistance, compensatory hyperinsulinemia, dyslipidemia and central obesity, which increase the risk for long-term complications like type 2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Moreover, previous data demonstrated that, compared to normo-ovulatory women, PCOS patients might exhibit a dysregulation in the IGF system represented as an elevation in the serum levels of free Insulin-like growth factor-1 (IGF-1) and a reduction in the serum levels of Insulin-like growth factor binding protein-1 (IGFBP-1). However, the exact aetiology of PCOS remains unclear and current treatments are only moderately effective at controlling PCOS symptoms and preventing its complications. Growing evidence suggests a role of vitamin D in female reproductive diseases as the expression of Vitamin D Receptors (VDR) was identified in many organs throughout the female reproductive tract. On the top of that, vitamin D regulates over 300 genes, including genes that are important for glucose and lipid metabolism. Moreover, vitamin D deficiency is a common condition among women with PCOS, and several studies indicated an association between low levels of serum 25-hydroxyvitamin D (25-OH-Vitamin D) and manifestations of PCOS including insulin resistance, hyperandrogenism, and infertility. Further, a recent in-vitro study showed that vitamin D regulated steroidogenesis and IGFBP-1 production in cultured human ovarian cells, and many reports have suggested an interrelation between IGF-1 and vitamin D.
A significant number of children (\>30%) are malnourished upon admission to the Pediatric Intensive Care Unit (PICU). In addition, critically ill children are at risk to develop new or worsened malnutrition during their PICU stay. Adequate nutritional support of critically ill children reduces mortality and morbidities, such as hospital acquired health care infections. Inadequate nutrition during hospitalization results in poor healing, increased risk for hospital acquired conditions, and prolonged length of stay, all of which contribute to increased health care costs. Even previously healthy children experiencing critical illness are at high risk for malnourishment because of increased protein and/or caloric needs at a time when oral intake is inadequate to meet their metabolic needs. A gap in the literature exists regarding the effectiveness of 2 delivery modes for gastric enteral nutrition: continuous gastric (stomach) feeding (CGF), the steady infusion of liquid nutrition is delivered at an hourly volume via an infusion pump, and bolus gastric feeding (BGF), whereby nutrition is intermittently delivered over a prescribed period of time, followed by a period of rest.

Enteral nutrition (EN, or tube feeding) in the PICU is commonly given via continuous gastric feeding. However, feeding by bolus or intermittent methods better mimics normal body function and may minimize interruptions to feedings improving nutritional intake. This study proposes to address the gap in the literature regarding the best method to deliver EN to achieve prescribed nutritional goals and avoid feeding interruptions in the mechanically ventilated, critically ill pediatric population.

This multi-center, prospective, randomized, controlled study includes children 1-month to 12-years who are on a ventilator and have EN started within 48-hours of admission. Subjects are randomized to CGF or BGF. Feeding volume is advanced in a weight-based manner every 3-hours to target volume; caloric density is then increased to goal. Feeding intolerance measures are assessed every 3-hours. Study sites are assigned to follow one of two feeding intolerance criteria to better define the measures and thresholds necessary to halt and resume feeds for safety purposes. Incidence, duration and category of feeding interruptions are recorded. Statistical significance is defined as p \< 0.05. The findings will be submitted for oral and poster presentation and manuscripts submitted for publication.

As the focus of nursing remains not on disease and cure, rather on healing and health, nutrition is embedded in this philosophy. Our vision of nursing is to put the patient in the best position to heal him or herself. Mitigating existing malnutrition and/or avoiding newly acquired nutritional deficits decreases the risk of mortality and hospital acquired adverse events in this population. This study seeks to optimize delivery of nutrition as therapy as imperative to optimize clinical and functional outcomes in the critically ill child.
PURPOSE:To obtain the subject compound having an angiotensin transferase- inhibiting action by separating and collecting the nicotianamine from the extraction solution of soybean with a synthetic adsorption resin. CONSTITUTION:Soybean capable of being stably supplied as a raw material as such is extracted with water or 45-130 deg.C hot water without crushing the soybean. Nicotianamine in the extraction solution is separated and collected with a synthetic adsorption resin (e.g. DIAON HP.20 resin, produced by Mitsubishi Kasei Co.) to obtain the nicotianamine. Since soybean-boiled waste solutions or soybean-immersed waste aqueous solutions by-produced in a process for producing soybean processed foods can be utilized for the production of the nicotianamine, the nicotianamine can be obtained at a greatly low cost. Since the nicotianamine is further has excellent water solubility, the nicotianamine can be added to various beverages and foods, thereby giving healthy foods having antihypertensive actions and having good tastes.
Background/Objectives: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems, which persist for a long time. The aim of the study was to assess the effect of a multidisciplinary personalized lifestyle intervention for depressive and anxiety symptoms, as evaluated by psychometric questionnaires, and their effect and association with cardiometabolic parameters in children and adolescents with overweight and obesity before and after the intervention. Methods: Six hundred and eleven (n = 611) children and adolescents (mean age ± SE: 10.39 ± 0.10 years; 51.5% females, 46.6% pubertal) were studied prospectively. Subjects were classified as being obese (50.2%), overweight (33.5%), or having a normal BMI (16.2%) according to IOTF criteria. All participants entered a 1-year lifestyle intervention program; laboratory investigations were obtained at the beginning and end of the study and two psychometric questionnaires were completed, the CDI and SCARED, which evaluate symptoms of depression and anxiety, respectively. Results: Following the lifestyle intervention, a significant decrease was noted in anxiety scores in all subjects and in depression scores in youth with obesity, as well as in adolescents with obesity, while females displayed a reduced response to the intervention. Insulin resistance and metabolic syndrome parameters, cortisol, PRL, and LH concentrations were positive predictors for depressive and anxiety symptoms. Conclusions: The implementation of a multidisciplinary personalized lifestyle intervention program in the management of childhood obesity is associated with a significant decrease in cardiometabolic and psychosocial comorbidities in children with and without excess adiposity. The improvement in mental health is likely mediated by an improvement in energy metabolism with subsequent improvement in neuroinflammation owing to lifestyle changes.
UNLABELLED: The role of mast cell (MC), a common myeloid-derived immune cell, in the development of oral squamous cell carcinoma (OSCC) is unclear. The aim of this study was to investigate MC infiltration in oral precancer and oral cancer. The evaluation of immune cell infiltration and its association with prognosis in OSCC used RNA sequencing and multiple public datasets. Multiplex immunofluorescence was used to explore the infiltration of MC in the microenvironment of OSCC and oral precancer and the interaction with CD8+ cells. The role of MC in OSCC progression was verified by in vivo experiments. The resting MC infiltration was mainly present in oral precancer, whereas activated MC infiltration was significantly higher in OSCC. Activated MC was associated with malignant transformation of oral precancer and poor prognosis of OSCC. In vivo studies showed that MC promoted the growth of OSCC. The infiltration of activated MC was negatively correlated with the infiltration of CD8+ T cells. The subtype of MC containing tryptase without chymase (MCT) was significantly higher in OSCC compared with oral precancer and was associated with poor survival. Furthermore, spatial distance analysis revealed a greater distance between MCT and CD8+ cells, which was also linked to poor prognosis in OSCC. Cox regression analysis showed that MCT could be a potential diagnostic and prognostic biomarker. This study provides new insights into the role of MC in the immune microenvironment of OSCC. It might enhance the immunotherapeutic efficacy of OSCC by developing targeted therapies against MC.
SIGNIFICANCE: In this study, we investigated the role of mast cells (MC) in oral precancer and oral cancer and demonstrated that MCs are involved in oral cancer progression and may serve as a potential diagnostic and prognostic marker. It might improve the immunotherapeutic efficacy through developing targeted therapies against MCs.
The LNG-IUS is a contraceptive method with high efficacy, long acting, reversible with contraceptive failure between 0.1 and 0.5/100 women/year. It released 20 mcg/day of LNG with a life span duration of 5 years. LNG is a synthetic progestin, 19-northestosterone, six times more potent than progesterone, with androgenic properties and with binding with sexual hormones, receptors of human steroids, including receptors of glucocorticoids and mineralocorticoids, with minimal capacity of binding with estrogen receptors. At endometrium level it induce antiproliferative effect and strong expression of local markers and endometrial decidualization, including the prolactin receptor and insulin-like growth factor. The mechanism of action includes effect upon cervical mucus which affects the sperm movements through the reproductive tract which affects fertilization. In some women could be ovulation inhibition. One of the main reason for discontinuation is breakdown bleeding, increase bleeding or abnormal bleeding including heavy menstrual bleeding (HMB) and spotting which is common at the first six month of use. Despite the fact that it is the main cause of discontinuation, there is no effective treatment for these cases. An effective treatment could help in the reduction of reduce the rates of discontinuation, improved the cost-effectiveness and quality of life of users.

A selective progesterone receptor modulator (SPRM) is Ulipristal Acetate (UPA) is approved in the European Union as Esmya® as a tretament to reduce the ueterine leiomyomas at te dose of 5 mg/day and it under evaluation at the dose of 5-10 mg as oral contraceptive.

This could be an option of treatment for HMB or abnormal bleeding induced by the LNG-IUS. UPA is agonist/antagonist and binding with progesterone to the receptor level. It has ovarian and endometrial activity, with dose-dependent effect in inhibition of ovulation and maturation of the endometrium. There are restricted evidences, that the administration of UPA induce a quick endometrial atrophy and stop the abnormal bleeding.
Glucocorticoid-induced osteonecrosis of the femoral head (GONFH) is a common refractory joint disease characterized by bone damage and the collapse of femoral head structure. However, the exact pathological mechanisms of GONFH remain unknown. Here, we observed abnormal osteogenesis and adipogenesis associated with decreased β-catenin in the necrotic femoral head of GONFH patients. In vivo and in vitro studies further revealed that glucocorticoid exposure disrupted osteogenic/adipogenic differentiation of bone marrow mesenchymal cells (BMSCs) by inhibiting β-catenin signaling in glucocorticoid-induced GONFH rats. Col2+ lineage largely contributes to BMSCs and was found an osteogenic commitment in the femoral head through 9 mo of lineage trace. Specific deletion of β-catenin gene (Ctnnb1) in Col2+ cells shifted their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of GONFH in adult mice. Overall, we uncover that β-catenin inhibition disrupting the homeostasis of osteogenic/adipogenic differentiation contributes to the development of GONFH and identify an ideal genetic-modified mouse model of GONFH.
1. Water-soluble, low molecular lignoid active agent, characterized in that it shows a) as solid an ESR spectrum according to Fig. 1, b) in aqueously neutral solution an ESR spectrum according to Fig.2, in aqueously alkaline solution at pH 10 an ESR spectrum according to Fig.3, c) in aqueous solution a fluorescence spectrum according to Fig.4 to 6, d) in the chromophoric group test with increase of the pH value from the acid to the basic range a decline of transparency from 100 % to about 20 % and e) in the glutathione redox status test according to Hohorst et al., 1959, Biochem. Z. 332, 18-46, beginning with 60 sec. after the application a characteristic increase of the reduced glutathione with simultaneous decline of the oxidized glutathione and the mixed glutathionedisulfides according to table (cf. page 12).
The invention discloses a gemini quaternary ammonium salt bactericide containing naphthalene ring rigid connecting groups, and a preparation method and application thereof, and relates to a surfactant bactericide and a preparation method thereof. The invention aims to solve the technical problem that the addition amount of the existing surfactant is large when the surfactant is used as a bactericide. The structural formula of the bactericide of the invention is as follows: wherein R ═ C n H 2n+1 N is 10 to 18, and X is halogen. The preparation method comprises the following steps: reacting N-acetyl- (1, 5-naphthalenedioxy) -N, N-dimethylethylenediamine with halogen acetylalkylamine, evaporating, and recrystallizing to obtain the final product. The application of the bactericide is to kill bacteria. The minimum inhibitory concentration of the bactericide on escherichia coli and salmonella reaches 0.17-0.66 mu M, the minimum inhibitory concentration on streptococcus reaches 0.17-1.32 mu M, and the minimum inhibitory concentration on staphylococcus aureus reaches 0.043-0.085 mu M. Can be used in the field of livestock and poultry, livestock houses and livestock carrying disinfection.
Adult patients (≥ 18 years of age) with acute coronary syndrome which are diagnosed under International Classification of Disease (ICD-10) coding of I24.9 were included in this study. The inclusion criteria are patients with primary diagnosis of I24.9 and with a complete record of prior medical and treatment history, electrocardiographic findings, cardiac marker results and outcomes. Participants were grouped into 2 groups - diabetic and non-diabetic based on history of diabetes prior to ACS. Diagnosis of ACS was made based on clinical, electrocardiographic and cardiac marker findings found in the medical record.

Data such as age, sex, ethnic, education, prior medical and treatment history, electrocardiographic and cardiac enzyme results as well as outcomes were collected from the patients' medical records. Outcomes of interest were defined as either concomitant heart failure, acute lung edema, malignant arrhythmia, mortality or combinations of them as diagnosed in the medical records. Heart failure is defined based on echocardiographic findings from the medical records. Acute Lung Edema is defined based on medical records or reported clinical findings of lung edema - rhonchi reported in 1/3 of the lungs with oxygen saturation \<90%. Whereas malignant arrhythmia is defined as the presence of ventricular tachycardia (VT) or ventricular fibrillation (VF).
The invention relates to a manufacturing method of a single and isometric gastric ulcer model induced by acetic acid in a rat. The method comprises procedures as follows: the rat is fasting but drinks freely for 24 hours; the chloral hydrate of 10 percent (0.3nl/100g weight) is used for anesthetizing the rat by muscle administration; lodophor is used for sterilizing the abdomen skin of the rat; a cut is made on the side wall of the abdomen and a stomach is pulled out slightly; the nipper with an annular front end (with the inner diameter of 9mm) clamps a corpus ventriculi part 3mm away from a pyloric part; after a distal stomach-antrum is penetrated, 0.81ml of the mineral oil and the acetic acid solution of 160 percent of 0.02ml ( with the total volume of 0.2ml) are injected into a lumen; after 45 seconds, the mixed solution of acetic acid and the mineral oil is absorbed from stomach; afterwards, the physiological saline of 2ml is injected into a gastral cavity for flushing and is drained off after 1min; and at last, the stomach is put back and the abdomen is sewed up. After an operation, the rat is carried out usual care. The method is easy to be handled and can make a single round ulcer with the inner diameter of 9mm. The area and the depth of the ulcer can be controlled. In addition, the problem of adhesion can be solved; the ulcer is extremely similar with the human ulcer in pathological features and healing mechanism; and the ulcer model is very sensitive to various anti-ulcer drugs.
Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular or CNS disorders, wherein the rAAV comprises one or more amino acid substitutions that interact with a heparan sulfate proteoglycan. The present invention provides methods for improved transduction of retinal cells, and methods of treating ocular diseases with improved compositions of rAAV particles. Also provided herein are improved recombinant adeno-associated viruses (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for use in enhanced gene therapy of CNS disorders. The present invention provides methods for delivering rAAV to the CNS, methods of treating CNS disorders with improved compositions of rAAV particles, and kits for delivering rAAV to the CNS and/or treating CNS disorders.
OBJECTIVE: The study of caries lesions of children 7 and 12 years old with different degrees of severity of autism and concomitant intellectual disabilities, in comparison with a control group of neurotypical patients of similar age.
MATERIALS AND METHODS: The main study group included children with ASD ages 7 and 12 (n=214), and the comparison group included neurotypical children of the same age (n=140). To assess the incidence of dental caries, indicators of the prevalence and intensity of the process were used.
RESULTS: The prevalence of dental caries in children with ASD is lower than in the comparison group or comparable. The average caries prevalence was found in the 7- and 12-year-old groups in children with mild autism without concomitant intellectual deficits (80.89±3.40 and 76.65±4.24, respectively). In children with severe and extremely severe autism, regardless of the presence of intellectual disability, the prevalence of dental caries was high in both age groups, which is comparable with the same indicator and age of neurotypical children. Moreover, both age groups of neurotypical children were also comparable in caries prevalence (89.67±1.65 and 90.32±1.20 respectively). Caries intensity did not seem to be related to years of autistic disorder (significantly lower in the group of 12-year-old children with ASD, compared to 7-year-olds). Caries intensity in children with ASD increased with increasing severity of autism and concomitant intellectual disability.
CONCLUSION: Further comprehensive studies in terms of included variables are needed to identify contributing factors (impact of family socioeconomic opportunities, increased parental care, etc.).
The present invention relates to a ginseng stem leaf total saponin orally disintegrating tablet and a preparation process thereof. The ginseng stem leaf total saponin orally disintegrating tablet can invigorate the spleen and nourish qi and is used for treating palpitation, shortness of breath, weariness, asthenia, anorexia, etc. caused by qi deficiency. The present invention aims at making up for the preparation insufficiency of existing ginseng stem leaf total saponin preparation and providing a ginseng stem leaf total saponin orally disintegrating tablet and a preparation process thereof for all patients and medical workers; the ginseng stem leaf total saponin orally disintegrating tablet has the advantages of convenient use and rapid absorption and effect-taking. Ginseng stem leaf total saponin is used as raw material; filling agents, disintegrating agents, corrigents, flow aid, lubricating agents, etc. are used as auxiliary materials; adhesives or coating materials can also be used according to different situations; appropriate quantity of effervescent agents can be added on specific situation; the orally disintegrating tablet is prepared by a specific preparation method and obtained after tabletting by tabletting machines. The orally disintegrating tablet of the present invention has the characteristics of good friability, rapid disintegration, good taste, no gravel feel, no need of specific production condition, low production cost, convenient carry, storage, transportation and use, etc.; most of all, the orally disintegrating tablet can be taken without water and takes effect quickly, and therefore, the present invention improves the patient's compliance and enhances the curative effect of the medicine.
FIELD: organic chemistry. SUBSTANCE: products: mono- or polyunsaturated compound of the formula (II) CH 2 = CH-R where R 2-propylpentyl nonobligatory containing one internal double bond, or 2-substituted 2-propylpentyl where substituent is removal group at position 2 is interacted with morpholine nitron of the formula (III)  , and compound of the formula (IV)   is synthesized where R as indicated above as a mixture of syn- and anti-isomers followed by reductive ring disclosure in synthesized compound. Prepared mixture of compounds of the formula (Va)  , (Vb)   and (Vc)   where R 2-propylpentyl is treated with chlorinating agent. Prepared after chlorination mixture of compound of the formula (Va) with chloro-analogues of compounds (Vb) and (Vc) is subjected for dechlorination. Prepared compound of the formula (Va) is N-alkylated, and the end product is isolated. EFFECT: improved method of synthesis. 7 cl, 1 tbl
PURPOSE:To obtain a readily ingestible tonic beverage, containing drug effective ingredients beneficial to bodies and ingredients optimum for nutrition by using an extract of Houttuynia cordata Thunb. and acetic acid as principal ingredients. CONSTITUTION:Stems, leaves or roots of Houttuynia cordata Thunb. are washed with water, removed from sticking soil bacteria or molds, drained and then finely cut. The resultant stem, leaves or roots are subsequently dipped in acetic acid, kept at about 40 deg.C for 5 days and fermented. A sweetener is suitably added thereto and the obtained mixture is filtered to provide a solution, which is then thermally sterilized at 80 deg.C for 30min to afford a tonic beverage consisting essentially of an extract of the Houttuynia cordata Thunb. and acetic acid. A half-boiled egg, as desired, is dipped in the aforementioned tonic beverage, allowed to stand at about 35 deg.C liquid temperature for 2 days and the whole is then stirred to afford a mucilage, which is subsequently filtered and sterilized to afford a tonic beverage consisting essentially of the Houttuynia cordata Thunb., acetic acid and half-boiled egg.