anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In cataract surgery, the opaque lens is replaced by an artificial intraocular lens. Based on a preoperative measurement of the eye (biometry) the power of the artificial lens is calculated so that refractive errors may be corrected. If high corneal astigmatism is present a correction of this astigmatism is also possible and offered to the patients. This may lead to a certain degree of spectacle independence. The astigmatism is corrected by the implantation of a special toric lens (spherical and cylindrical correction). This toric lens has to be positioned in the eye so that the axis of the IOL-cylinder aligns 90° to the axis of the corneal cylinder. The axis of the corneal cylinder has to be measured and marked before the intervention. Usually, the intended axis of placement for the toric IOL is marked with ink at the slitlamp or with the aid of a manual axis instrument. Anatomical landmarks without preoperative marking are also used. A clinical trends survey of the European society of cataract and refractive surgery (ESCRS) for 2021 has revealed that in 15% of all cataract cases (totally 550'000 cases assessed) a special toric IOL was implanted to correct a clinically significant astigmatism. About 75% use manual marking with ink. Only 25% of cases were operated using a digital image registration.

The manual marking using a marking device is currently the gold standard. However, the manual marking might be not very precise. The thick ink-marks on the cornea and the limbus are not very well visible. Sometimes the marks are not perfectly centred on the optical axis of the eye. Head tilt and rotation of the eyeball if patients are not fixating may lead to a deviation up to several degrees.

One possible solution of this problem are digital imaging technologies. The Cassini topography instrument for example provides additional to the measurement of the axis and the cylindrical power of the cornea a digital image of the iris. If the cataract surgery is performed assisted by a femtosecond laser (FLACS), this digital image is transferred to the femtosecond laser. Based on this image the software of the laser is capable to determine the correct position of the axis of the cylinder of the cornea and the femtosecond laser can make two intrastromal marks in the cornea. These marks allow the surgeon to align the toric IOL without any preoperative manipulations with ink and marking tools.

The aim of this study is to assess the accuracy of topography guided automatic marking of the intended IOL-axis in toric IOL-implantation in femtosecond laser assisted cataract surgery (FLACS)
Peripheral artery disease (PAD) is a prevalent age-related vascular pathology and the third leading cause of cardiovascular morbidity and mortality among older adults. Accumulating evidence indicates that PAD is associated with generalized endothelial dysfunction that expands from the periphery to central circulation and from macro- to microcirculation. One of the mechanisms that contributes to vascular dysfunction in aging and age-related diseases is the decline in the Nicotinamide Adenine Dinucleotide (NAD) levels. Importantly, recent reports indicate that age-associated decreases in NAD are exacerbated in age-related diseases, including in patients with PAD. Clinical data demonstrate that NAD levels can be increased via per os supplementation with the NAD precursor nicotinamide riboside (NR). Although few ongoing studies provide initial evidence that NAD supplementation with NR may benefit vascular health in older adults, including potential improvements in blood pressure and aortic stiffness, the effects of NR supplementation on vascular health in PAD is understudied. This pilot open-label clinical trial was designed to investigate whether 4-week supplementation with 1g daily NR impacts endothelial function in peripheral circulation, cerebrovascular hemodynamics, cognitive function in older adults with peripheral artery disease.
The study will test the independent and moderating effects of a multilevel intervention and the community environment on physical activity among rural residents. The multilevel intervention consists of community, interpersonal, and intrapersonal aspects. The community level intervention consists of community events. The interpersonal level intervention consists of walking group formation. The intrapersonal level intervention consists of cues provided by short message service messages (i.e., text messaging). A dose response relationship is expected in the intervention communities.
Three intramuscular injections of LEISH-F3 + GLA-SE at Days 0, 28, and 56. Low dose of antigen and high dose of GLA-SE adjuvant.
Lack of knowledge about nutrition is one of the most important causes of nutritional problems. accordingly, wrong eating practices and habits can lead to many complications and health problems. Especially adolescent eating habits form the basis of adult eating habits. The habits acquired during this period can lead to behaviors and attitudes that persist for a long time and are difficult to change.The aim of this study is to determine the effect of nutrition education on nutritional literacy, nutritional status, eating habits and eating behavior in high school students. The research will be conducted in six high schools, three of which are intervention schools and three of which are control schools. Schools in the district will be divided into 3 layers as 1- Anatolian High Schools, 2- Technical and Vocational High Schools, 3- Imam Hatip High Schools, and a control school will be determined from each layer by means of a random numbers table. It is planned that a total of 1000 students will be included in the study from the intervention school and 1000 students from the control school. At the beginning of the study (June 2022), an introductory form (sociodemographic characteristics, body image (Stunkart scale), dietary habits, knowledge about weight status) was applied to all students. Adolescent Nutrition Literacy Scale (ANLS), Instrument of Nutrition Literacy, Mediterranean Diet Quality Index (KID-MED), Eating Attitudes Test 26 (EAT-26), International Physical Activity Questionnaire Short Form (IPAQ) were applied, anthropometric measurements and three-day food consumption records were taken. During the study, nutrition initiatives consisting of 8 modules (powerpoint supported classroom lesson, video demonstration, role-play, healthy plate model game, poster preparation, bookmarks, refrigerator magnets, etc. preparation of reminder messages, competitions such as slogan-painting contest, activities such as sports and nutrition festival) will be made to the intervention schools. Control schools will not be interfered with during this period.At the end of the study, the procedures applied at the beginning (anthropometic measurements, introductory form, scales, food consumption record) will be repeated.
The proposed single-center, participant-blind, two arms, randomized, sham-controlled clinical trial is to evaluate the efficacy and safety of electroacupuncture (EA) combined with standard Intensive Care Unit (ICU) therapy on organ dysfunction and other clinical outcomes in sepsis patients. We planned to conduct this single-center trial in Tongji Hospital, affiliated to Huazhong University of Science and Technology (HUST). Patients, who are initially diagnosed with sepsis, will be assessed for eligibility within 24 hours of their ICU admission. Then, eligible participants will be informed and randomly assigned to one of the two groups: the EA group or the sham EA group, in a 1:1 ratio using block randomization. Patients will receive the first EA/sham EA therapy within 24 hours after randomization. The treatment will be administered once daily for 6 days continuously, and followed by 28 days after randomization. The primary outcome will be the SOFA score at Day 7 after randomization. Secondary outcomes include mortality, ICU-free days, hospital-free days, organ-support-free days at Day 28. SOFA score components and related serological results will also be included. Data collection will be conducted by an electronic data management system. Data analyses will be performed on a full analysis set and a per protocol set.
The present invention provides a biological bandage, comprising an envelope enclosing cells which secrete biologically active cellular products such as growth factors, which promote the healing of wounds. The envelope is further comprised of a permeable bottom membrane through which the cellular product diffuses, and a top membrane. Preferably the bandage has a separator interposed between the two membranes. One embodiment of this separator is seen in the figure. This invention also relates to a method for treating wounds. The bandage provides a continuous, uniform source of fresh cellular product.
BACKGROUND: Coercion is rare in cancer treatment. We present a case where a young woman received gamma knife radiosurgery and immunochemotherapy under compulsory institutional care.
CASE PRESENTATION: A previously healthy patient in her thirties was admitted to hospital due to confusion, apathy, weight loss and sleep disturbance. She had difficulties expressing herself and spoke with considerable latency. A brain MRI revealed a tumour of 23 mm in the left-side centrum semiovale and perifocal oedema, while a CT scan showed a 5.6 cm tumour in the right upper lobe and enlarged mediastinal lymph nodes. She was diagnosed with non-small cell lung cancer, no actionable mutations, PD-L1 <75 %. When she did not wish to return to the hospital to undergo gamma knife radiosurgery, she was readmitted under a formal decision to use coercion, and remained under institutional care for over six months. Today she is fully recovered and has no cancer progression almost five years after diagnosis.
INTERPRETATION: This case report illustrates the challenges of brain metastases and use of coercion during cancer treatment, both for the patient and healthcare personnel. There is a need for thorough interdisciplinary discussions and to establish as early as possible a shared understanding of the intention and scope of the forced treatment.
Healthy normal volunteers will be recruited from friends and family of the investigators, and staff at the INCMNSZ. They will consume the fish oil equivalent to 4.8 g/day of EPA and DHA for 3 months, followed by a one-month period without treatment.
Two innovative series derived from nicotinic acid scaffold were synthesized and evaluated for their anti-inflammatory activity. Ibuprofen, celecoxib and indomethacin were used as standard drugs. All the newly synthesized compounds were in vitro screened for their anti-inflammatory activity adopting 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide dye (MTT), as well as Griess assays. The results showed that all compounds exhibited significant anti-inflammatory activity without affecting the viability of the macrophages compared to ibuprofen. In addition, compounds 4d, 4f, 4g, 4h and 5b exhibited the most potent nitrite inhibition activity and consequently superior anti-inflammatory activity with MTT results ranging between values 86.109 ± 0.51 to 119.084 ± 0.09. The most active compounds were subjected to evaluation of TNF-α, IL-6, iNOS and COX-2 levels in LPS/INF γ-stimulated RAW 264.7 macrophage cells in comparison to ibuprofen as a reference compound. The five compounds showed comparable inhibition potency of these inflammatory cytokines compared to ibuprofen. Same compounds were further in vivo evaluated for their anti-inflammatory activity via carrageenan induced arthritis in rats. Regarding the ulcerogenic profile, compound 4h showed mild infiltration of gastric mucosa superb to compound 5b displayed severe gastritis. Molecular docking of 4h and 5b in the COX-2 active site was performed to evaluate their preferential COX-2 inhibitory potency. The docking results were in accordance with the biological findings.
PURPOSE:To obtain a solid powder cosmetic having excellent appearance, extensibility, adhesion and touch free from coagulation of elastic powder, comprising mixed powder prepared by mutually uniformly dispersing and mixing elastic powder and different powder. CONSTITUTION:Elastic powder is premixed with at least one different powder while stirring, then treated by a closed multi-stage shear extruder to give mixed powder, which is subjected to a conventional production process to give a solid powder cosmetic. Silicone rubber, fluorosilicon rubber, etc., having 0.1-100mum average particle diameter is used as the elastic powder. Talc, mica, sericite, kaolin, etc., may be cited as the different powder. The blending ratio of the elastic powder and the powder to be sheared and mixed is preferably 10:90-70:30 by weight. This cosmetic has uniform appearance, excellent slip and adhesion and a smooth feeling in use.
A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
The invention belongs to field of health-care beverage, particularly a kind of Chinese medicine composition for the preparation of health liquor, health liquor and preparation method thereof. Should comprise for the preparation of the Chinese medicine composition of health liquor: saline cistanche 10-150 part, American Ginseng 10-50 part, matrimony vine 10-50 part, sealwort 10-50 part, safflower 1-5 part. By alcoholic strength, the white wine between 38-65%vol and aforementioned arbitrary proportioning Chinese medicine composition are prepared from the weight ratio of 6-40:1 this health liquor. Health liquor provided by the invention, adopts plurality of Chinese, and compatibility is coordinated mutually, respectively gets the chief, safe and effective, has ensured good taste and the security of product, has avoided the pained smell of medicine, and the people who drinks even uncomfortable also can accept. This health care vina of modern pharmacology test prompting has the function of alleviating physical fatigue. This health liquor can significantly improve the content of active ingredient in product, greatly enhances productivity, and has good commercial application prospect.
Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.
Considering the variability in individual responses to opioids and the growing concerns about opioid addiction, prescribing opioids for postoperative pain management after spine surgery presents significant challenges. Therefore, this study undertook a novel pharmacogenomics-based in silico investigation of FDA-approved opioid medications. The DrugBank database was employed to identify all FDA-approved opioids. Subsequently, the PharmGKB database was utilized to filter through all variant annotations associated with the relevant genes. In addition, the dpSNP ( https://www.ncbi.nlm.nih.gov/snp/ ), a publicly accessible repository, was used. Additional analyses were conducted using STRING-MODEL (version 12), Cytoscape (version 3.10.1), miRTargetLink.2, and NetworkAnalyst (version 3). The study identified 125 target genes of FDA-approved opioids, encompassing 7019 variant annotations. Of these, 3088 annotations were significant and pertained to 78 genes. During variant annotation assessments (VAA), 672 variants remained after filtration. Further in-depth filtration based on variant functions yielded 302 final filtered variants across 56 genes. The Monoamine GPCRs pathway emerged as the most significant signaling pathway. Protein-protein interaction (PPI) analysis revealed a fully connected network comprising 55 genes. Gene-miRNA Interaction (GMI) analysis of these 55 candidate genes identified miR-16-5p as a pivotal miRNA in this network. Protein-Drug Interaction (PDI) assessment showed that multiple drugs, including Ibuprofen, Nicotine, Tramadol, Haloperidol, Ketamine, L-Glutamic Acid, Caffeine, Citalopram, and Naloxone, had more than one interaction. Furthermore, Protein-Chemical Interaction (PCI) analysis highlighted that ABCB1, BCL2, CYP1A2, KCNH2, PTGS2, and DRD2 were key targets of the proposed chemicals. Notably, 10 chemicals, including carbamylhydrazine, tetrahydropalmatine, Terazosin, beta-methylcholine, rubimaillin, and quinelorane, demonstrated dual interactions with the aforementioned target genes. This comprehensive review offers multiple strong, evidence-based in silico findings regarding opioid prescribing in spine pain management, introducing 55 potential genes. The insights from this report can be applied in exome analysis as a pharmacogenomics (PGx) panel for pain susceptibility, facilitating individualized opioid prescribing through genotyping of related variants. The article also points out that African Americans represent an important group that displays a high catabolism of opioids and suggest the need for a personalized therapeutic approach based on genetic information.
The utility model discloses a pair of latex gloves or butyronitrile gloves having a skin protection function. The gloves comprise glove bodies. Skin protection layers are arranged on the glove bodies. The skin protection layers are arranged on the glove bodies so that when the gloves are in use, the hand skin of a user can be moistened and can continuously absorb nutrition, and therefore the hands of the user are protected. The using effect of the gloves is increased. Furthermore, the skin protection layers are arranged on the inner surfaces of the glove bodies, so that the gloves have the skin protection function and the processing cost of the gloves is reduced. Moreover, the skin protection layers are thin film layers formed by spraying skin protection liquid, so that the gloves in use are ensured to be flexible.
The invention relates to a hand pad capable of relaxing muscles and stimulating blood circulation. As rapid development of the current society, computers have become an inseparable tool in people life, bring convenience and happiness to us, and simultaneously bring a plurality of computer diseases. In a computer using process, the hand holds a mouse for a long time so as to cause long-time compression on joints, nerves and blood vessels at the wrist. Wrist pins and needles, head swimming and other feelings are presented. Under the condition of nervous spirit and attention of a user, the symptoms are ignored by the user often. If things go on like this, great damage is brought to the body.
Three districts in Ife North Local County with an estimated screening population (women 40-70 years) of 5,800 will be randomly selected to serve as the intervention community. Women in the intervention community will receive iBreast and clinical breast examinations by the community health nurses and get navigated to have ultrasound, mammography, biopsy and referral for treatment to the tertiary hospital if indicated within their community.
Opioid peptides and their G protein-coupled receptors are important regulators within the cardiovascular system, implicated in the modulation of both heart and vascular functions. It is known that naloxone-an opioid antagonist-may exert a hypertensive effect. Recent experimental and clinical evidence supports the important role of inflammatory mechanisms in hypertension. Since opioids may play a role in the regulation of both blood pressure and immune response, we studied these two processes in our model. We aimed to evaluate the effect of selective and non-selective opioid receptor antagonists on blood pressure and T-cell activation in a mouse model of high swim stress-induced analgesia. Blood pressure was measured before and during the infusion of opioid receptor antagonists using a non-invasive tail-cuff measurement system. To assess the activation of T-cells, flow cytometry was used. We discovered that the non-selective antagonism of the opioid system by naloxone caused a significant elevation of blood pressure. The selective antagonism of μ and κ but not δ opioid receptors significantly increased systolic blood pressure. Subsequently, a brief characterization of T-cell subsets was performed. We found that the blockade of μ and δ receptors is associated with the increased expression of CD69 on CD4 T-cells. Moreover, we observed an increase in the central memory CD4 and central memory CD8 T-cell populations after the δ opioid receptor blockade. The antagonism of the μ opioid receptor increased the CD8 effector and central memory T-cell populations.
PURPOSE:To provide a new compound useful as a therapeutic agent for infectious diseases by viruses, having high activity and low toxicity. CONSTITUTION:SO-75R1 of the formula. The compound of the formula has the following physical and chemical properties. Elemental analysis: C29H34O11. Molecular weight: 559. Melting point: 121-122 deg.C. Specific rotatation; +216 deg.C (c1.0, CHCl3). Solubility in solvent,: soluble in methanol, ethyl acetate, chloroform or acetonitrile and insoluble in n-hexane and water. Color of substance: showing red prism crystal. The compound of the formula is obtained by subjecting a bacterium belonging to the genus Nocardia brasiliensis IFM-0075 (FERM P-13,071) to shaking culture preferably at about 37 deg.C for 1-6 days and extracting SO-75R1 accumulated in the cells with methanol, acetone, etc.