anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses a pure biological product capable of increasing longevity. It is prepared from (wt. portion) soft-shelled turtle 100, herba agastachis 2-5, ginseng 2-5, glucose 2-5. These components are ground into powder respectively. then mixing powders according to proportion, adding water to the mixed powders and decocting, filtering them obtains aqueous agent, or the filtrate is dried to obtain powder, tablet or pill. It can increase the immunity of human body, promote cell disintegration and regeneration, quicken then metabolism of human body, thereby achieve the aim of preventing and treaitng cancer and increasing longevity.
This arm will start with a 6 week delay (no vision therapy) after baseline assessment to evaluate natural recovery. After 6 weeks, the first outcome assessment will be attained by a masked optometrist. The participant will have two sessions of one hour each for 8 weeks (16 office-based vergence and accommodative therapy sessions). The second and final outcome measurement will be attained. Assessments include a masked optometric vision exam, objective eye movement recordings and an functional MRI scan.
Excessive beta‑adrenergic stimulation has been associated with seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, palpitation, nausea, dizziness, fatigue, malaise, and insomnia [see Overdosage (10)]. Therefore, AIRDUO RESPICLICK, like all products containing sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension.

Salmeterol, a component of AIRDUO RESPICLICK, can produce a clinically significant cardiovascular effect in some patients as measured by pulse rate, blood pressure, and/or symptoms. Although such effects are uncommon after administration of salmeterol at recommended doses, if they occur, the drug may need to be discontinued. In addition, beta‑agonists have been reported to produce electrocardiogram (ECG) changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The clinical significance of these findings is unknown. Large doses of inhaled or oral salmeterol (12 to 20 times the recommended dose) have been associated with clinically significant prolongation of the QTc interval, which has the potential for producing ventricular arrhythmias. Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs.
The case group will consist of newborns born between 32 and 41 weeks gestation diagnosed with a congenital cardiac anomaly requiring surgical repair during their hospitalization and managed in the Mount Sinai Neonatal Intensive Care Unit. The control arm will include newborns born between 32 and 41 weeks without congenital cardiac anomalies. Both groups will undergo a neurological screening assessment and receive an AEEG to look at sleep wake cycles.
In aim 1, the study team will compare 129Xe MRI signatures to lung explant pathology, cellular identity from single-cell RNA sequencing, and cellular phenotypes in gas exchange defects to areas that are spared, which the team will hypothesize are exposed to lower levels of hemodynamic shear stress. This will be done by performing 129Xe MRI scans in fifteen subjects (cohort 1) with PAH awaiting a lung transplant, followed by a pathologic assessment (with usual histopathology and single cell RNA sequencing) of the subject's explanted lung after transplant. The study team expect that areas of proliferation and fibrosis will correlate with 129Xe MRI gas exchange and spectroscopic defects

In aim 3, The study team will test whether directly monitoring lung pathology with 129Xe MRI will provide additional prognostic information to standard-of-care clinical monitoring in 45 subjects (cohort 2). At 6-month follow-up appointments, standard-of-care assessments including labs, echocardiography, and six-minute walk distance and 129Xe MRI will be collected. The study team expect that In aim 1, the study team will compare 129Xe MRI signatures to lung explant pathology, cellular identity from single-cell RNA sequencing, and cellular phenotypes in gas exchange defects to areas that are spared, which the study team hypothesizes are exposed to lower levels of hemodynamic shear stress. This will be done by performing 129Xe MRI scans in fifteen subjects (cohort 1) with PAH awaiting a lung transplant, followed by a pathologic assessment (with usual histopathology and single-cell RNA sequencing) of the subject's explanted lung after transplant. The study team expect that areas of proliferation and fibrosis will correlate with 129Xe MRI gas exchange and spectroscopic defects
BACKGROUND: Early detection of long-term, often asymptomatic, middle ear infection in young Aboriginal and Torres Strait Islander children is more likely to be achieved when ear health and hearing checks are routinely undertaken in primary healthcare. Evidence consistently demonstrates the adverse impacts of this condition on the development and wellbeing of children and their families. We aimed to develop feasible, evidence- and consensus-based primary healthcare recommendations addressing the components and timing of ear health and hearing checks for Aboriginal and Torres Strait Islander children aged under 6 years, not already known to have, nor being actively managed for, ear and hearing problems.
METHODS: A 22-person working group comprising Aboriginal and Torres Strait Islander and non-Indigenous members from the primary healthcare, ear, hearing, and research sectors provided guidance of the project. A systematic scoping review addressed research questions relating to primary health ear health and hearing checks for Aboriginal and Torres Strait Islander and other populations at increased risk of persistent ear health problems. Twelve primary studies and eleven guidelines published between 1998 and 2020 were identified and reviewed. Quality and certainty of evidence and risk of bias ratings were completed for studies and guidelines. In the absence of certain and direct evidence, findings and draft recommendations were presented for consensus input to a 79-member expert panel using a modified e-Delphi process. Recommendations were finalised in consultation with working group members and presented to expert panel members for input on considerations relating to implementation.
RESULTS: Overall, the quality, certainty, and directness of evidence in the studies and guidelines reviewed was low. However, the findings provided a basis and structure for the draft recommendations presented during the consensus-building process. After two e-Delphi rounds, seven goals and eight recommendations on the components and timing of Ear Health and Hearing Checks in primary healthcare for young Aboriginal and Torres Strait Islander children were developed.
CONCLUSIONS: The systematic scoping review and consensus-building process provided a pragmatic approach for producing strong recommendations within a reasonably short timeframe, despite the low quality and certainty of evidence, and paucity of studies pertaining to primary healthcare settings.
Participants who had received Placebo in Part 1, received Gantenerumab at doses up to 1200 mg by SC injection Q4W for up to 2 years. Additionally, participants were given the option to continue receiving open-label gantenerumab treatment for 3 years.
PROBLEM TO BE SOLVED: To efficiently obtain an alum block having exclusive transparency, impact resistance, shearing strength, preservable property, etc., by adding a specific amt. of aluminum sulfate to a hot soln. of alum and cooling this soln, thereby crystallizing the soln. to a block form. SOLUTION: The aluminum sulfate is added and dissolved at 0.05 to 20wt.%, more preferably 5 to 15wt.% in terms of the aluminum sulfate of aluminum oxide concn. of 17% to the alum to and in the hot soln. prepd. by dissolving the alum. The alum to be used is preferably the 12-hydrated salt, etc., of potassium aluminum sulfate. This hot soln. is then injected into a molded vessel and thereafter, the hot soln. is cooled while the evaporation of the moisture from the open surface is prevented by sealing the open surface of the hot soln., by which the alum crystal is grown to the block form and the alum block is obtd. The method of sealing the open surface of the hot soln. includes a method of covering the open surface with a thermally and chemically stable low-sp. gr. liquid, such as silicone oil, a method of covering the open surface with a film, wrap, etc., and other methods.
Despite abundant clinical innovation and burgeoning scientific investigation, pulmonary embolism (PE) has continued to pose a diagnostic and management challenge worldwide. Aging populations, patients living with a mounting number of chronic medical conditions, particularly cancer, and increasingly prevalent health care disparities herald a growing burden of PE. In the meantime, navigating expanding strategies for immediate and long-term anticoagulation, as well as advanced therapies, including catheter-based interventions for patients with more severe PE, has become progressively daunting. Accordingly, clinicians frequently turn to evidence-based clinical practice guidelines for diagnostic and management recommendations. However, numerous international guidelines, heterogeneity in recommendations, as well as areas of uncertainty or omission may leave the readers and clinicians without a clear management pathway. In this review of international PE guidelines, we highlight key areas of consistency, difference, and lack of recommendations (silence) with an emphasis on critical clinical and research needs.
Schoolchildren received enriched cookies containing a multiple micronutrients formula. Enriched cookies (20g) with a daily dose of 0.33g of organic mix formula were given in the morning during 4-weeks. The formulation is an industrial secret of UNAM.
Pathogenic variants in solute carrier family 34, member 3 (SLC34A3), the gene encoding the sodium-dependent phosphate cotransporter 2c (NPT2c), cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Here, we report a pooled analysis of clinical and laboratory records of 304 individuals from 145 kindreds, including 20 previously unreported HHRH kindreds, in which two novel SLC34A3 pathogenic variants were identified. Compound heterozygous/homozygous carriers show above 90% penetrance for kidney and bone phenotypes. The biochemical phenotype for heterozygous carriers is intermediate with decreased serum phosphate, tubular reabsorption of phosphate (TRP (%)), fibroblast growth factor 23, and intact parathyroid hormone, but increased serum 1,25-dihydroxy vitamin D, and urine calcium excretion causing idiopathic hypercalciuria in 38%, with bone phenotypes still observed in 23% of patients. Oral phosphate supplementation is the current standard of care, which typically normalizes serum phosphate. However, although in more than half of individuals this therapy achieves correction of hypophosphatemia it fails to resolve the other outcomes. The American College of Medical Genetics and Genomics score correlated with functional analysis of frequent SLC34A3 pathogenic variants in vitro and baseline disease severity. The number of mutant alleles and baseline TRP (%) were identified as predictors for kidney and bone phenotypes, baseline TRP (%) furthermore predicted response to therapy. Certain SLC34A3/NPT2c pathogenic variants can be identified with partial responses to therapy, whereas with some overlap, others present only with kidney phenotypes and a third group present only with bone phenotypes. Thus, our report highlights important novel clinical aspects of HHRH and heterozygous carriers, raises awareness to this rare group of disorders and can be a foundation for future studies urgently needed to guide therapy of HHRH.
<P>PROBLEM TO BE SOLVED: To provide a drug which effectively and selectively silences a gene in a JC virus using a RNAi mechanism of a cell itself, has both high biological activity and biostability, and effectively inhibits a replication of the JC virus used for a treatment during a pathological process mediated by a JC virus infection.  <P>SOLUTION: The invention relates to a double stranded ribonucleic acid (dsRNA) for inhibiting an expression of a JC virus gene (JC virus genome). The dsRNA includes an antisense strand having a nearly complementary nucleotide sequence in at least part of a JC virus gene. The nucleotide sequence is less than 30 nucleotides in length and usually 19-25 nucleotides. The invention also relates to: a pharmaceutical composition including the dsRNA together with a pharmaceutically acceptable carrier; methods of treating diseases caused by the expression of a JC virus by using the pharmaceutical composition; and methods of inhibiting the expression of a JC virus in a cell.  <P>COPYRIGHT: (C)2011,JPO&INPIT
The study is aimed at determining the effects of ELDOA in treating disc protrusion at lumbar region and is being conducted in Max Rehab \& Physical Therapy Centre Islamabad and Pakistan Railway General Hospital, Rawalpindi (March 2019-June 2019). Sample size of the study is 34 with confidence interval of 95% and power of 0.8. 30 patients were screened and 29 were included in the study on the basis of inclusion criteria. Sealed envelope contained total 34 questionnaires, 17 for each group. Patients were allocated randomly on the basis of group mentioned on the Performa. Similar conservative rehabilitation protocol was designed for both control and experimental group except for experimental group had ELDOA Exercises in addition. Patients were examined at 1st visit before administration of any treatment and at 4th visit which was also the last one (after completing 4 sessions at alternate days). Baseline evaluation for demographics and symptomatology was taken. Self-reported questionnaire, ODI, NPRS, lumbar ROM and SLR were recorded at first and fourth visit for comparison. 26 patients completed the study while 1 patient from control group and 2 patients from experiment group were lost to follow up and were considered drop outs.
After screening and standard of care hematopoietic stem cell transplantation (HCT) and any standard treatment before and after the HSCT, Ivosidenib will be given orally (PO) once daily (QD) in 28-day continuous cycles. Ivosidenib is administered at a pre-determined dose with a goal of 500mg daily. Participants begin study treatment 45 to 90 days after HCT, and treatment will continue for up to 24 months. Study visits and assessments occur throughout study treatment and in follow-up. After the 24-month treatment period, participants are followed for up to 12 additional months.
This invention refers to medicine, in particular to pharmacology and concerns to method for preparing preserved medicinal means containing human protein and to medicinal means.      Technical result of the invention is to avoid immune reaction and to increase the stability of the medicinal means.    To human protein there are added auxiliary agents and at least one preservative selected from the group of chlorobutanol, benzyl alcohol, benzalko¬niu¬michloride or the combination thereof with the concentration of the preservative 0,001-2,0%.    Medicinal means comprises an effective quantity of human protein, auxiliary agents and at least one preservative selected from the group of chloro¬bu¬tanol benzyl alcohol, benzalkoniu¬michlo¬ride or from the combination of these agents the concentration of the preservative being 0,001-2,0%.    2ind. cl. 9 dep. cl.
The present invention discloses a traditional Chinese medicinal feed additive for preventing avian influenza. The feed additive comprises the following raw materials: 20-30 parts of radix bupleuri, 20-30 parts of solidago decurrens, 20-25 parts of coptidis rhizoma, 15-20 parts of sunflower plates, 20-25 parts of radix angelicae, 20-40 parts of radix isatidis, 25-30 parts of magnolia liliflora, 20-30 parts of radix astragali and 15-20 parts of dandelions. The ingredients are ground into powder, the powder is stirred evenly with the feed, and the feed additive can be used in the daily feeding of domestic poultries, can effectively reduce the incidence of the avian influenza, and also have obvious treatment effects in the avian influenza onset. Due to no use of any antibiotics, people are safer to eat the domestic poultries. After the domestic poultries eat the Chinese herbal medicines, the meat of the domestic poultries contains fragrance of parts of the Chinese herbal medicines and is rich in medicinal ingredients of the Chinese herbal medicines. The mouthfeel is better after the eating and the feed additive also has supplementing functions of the traditional Chinese medicines for human body.
The invention relates to the technical field of functional foods, and particularly discloses application of safflower honey in preparation of an anti-radiation product. The research shows that the safflower honey can improve the oxidation resistance of organism tissues, remove excessive free radicals generated by radiation in time and resist the damage of the radiation to organisms. Further provides the application of the safflower honey in preparing anti-radiation products. The active ingredient of the radiation-resistant product can be only safflower honey. Safflower honey contains syringaldehyde, 4-hydroxybenzoic acid, p-hydroxybenzaldehyde, p-coumaric acid, riboflavin, photochrome, and tri-p-coumaroyl spermidine. The safflower honey can improve the oxidation resistance of organism tissues, timely remove excessive free radicals generated by radiation, resist the damage of the radiation to organism and has wide food and medical application prospect.
Deafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown that Luzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance of Luzp2 in auditory function, we generated mice deficient in Luzp2. Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells. However, the loss of Luzp2 did not result in any changes in auditory threshold. HCs or synapse number and HC stereocilia morphology in Luzp2 knockout mice did not show any notable distinctions. This was the first study of the role of Luzp2 in hearing in mice, and our results provide important guidance for the screening of deafness genes.
FIELD: medicine. SUBSTANCE: method involves administering food additive to daily allowance of food to be taken within 21 days period before applying loading. The additive has protein aminoacid concentrate, vitamins, mineral substances, unsaturated fat acides and succinic acid with lactic bacteria. Dried Bifidobacteria or lactic bacillae are useable as the lactic bacteria. EFFECT: optimized metabolism processes; increased resistance and fitness for work. 7 tbl
BACKGROUND: Adherence to preoperative weight loss recommendations may serve as a surrogate for the level of engagement in hiatal hernia (HH) patients. This study aims to evaluate the relationship between achieving preoperative weight loss goals and outcomes after HH repair.
METHODS: A retrospective review of 235 patients undergoing laparoscopic HH repair at a single institution was performed. Patients were grouped based on the percentage of weight loss goal achieved. Low achievement was defined as the bottom quartile of goal achievement (≤75%); high achievement was defined as the top quartile (≥140%). Baseline characteristics, clinical outcomes, and patient reported outcomes (PROMs) were compared between groups.
RESULTS: 131/235 (55.7%) achieved their weight loss goal. No differences in baseline characteristics or clinical outcomes were observed between the low and high achievement groups. While both groups experienced improvements in PROMs postoperatively, patients in the high achievement group demonstrated significantly lower symptom burden at one-month postoperatively. Further, high-achievement patients were more likely to experience complete resolution of common HH symptoms at one-month postoperatively, including no difficulty swallowing food, no breathing difficulties or choking episodes, no choking when eating food, no choking when drinking liquid, and no regurgitation of food or liquid.
CONCLUSIONS: In patients undergoing laparoscopic HH repair, patients achieving their preoperative weight loss goals experienced less overall symptom burden and lower prevalence of common symptoms one-month postoperatively than those with low levels of goal achievement. These results demonstrate that patients can take an active role in improving their own surgical outcomes and health status.
Systems and methods are described that enable patching of security vulnerabilities in binary files. The detection and patching of vulnerable binary files is automatic, reliable, regression free, and comprehensive across networks on an unlimited scale. These advantages can be realized in various ways including, for example, by leveraging current anti-virus infrastructure that is widely deployed across the Internet. Reliable discovery of vulnerable binary files (e.g., in operating systems, application programs, etc.) is achieved through the use of binary signatures that have been associated with discovered security vulnerabilities. A divergence of security patches away from conventional service packs provides for the possibility of production of regression-free fixes for security vulnerabilities in binary files.
Subjects will receive GSK2245035 - 160 ng or placebo once per week, for four treatment weeks. There will be washout period of 7 days between treatment periods.
Inclusion Criteria: Angiogram Cohort. Patients who present 1) directly through the study site Emergency Department (ED) OR 2) as a transfer or referral patient from the ED of another institution OR 3) as a direct admission to the study site's Catheterization Laboratory by an ambulance service, who also met the following criteria: 1.Underwent urgent or emergent coronary angiography during the index presentation for suspected ischemic symptoms (including but not limited to chest pain \[CP\] and/or shortness of breath \[SOB\]) AND 2. Had a VPR ECG recorded during the index presentation prior to the angiogram AND 3. Had sufficient troponins to rule in or rule out acute myocardial injury, per the study site's institutional protocol. From this Angiogram Cohort, a group of patients will be identified who had angiographic evidence of ACO, defined as an acute lesion with TIMI flow 0 or 1 when evaluated by an experienced study-site adjudicator.
Lyumjev and pramlintide fully automated delivery system with no meal announcement. Ratio of 1 unit of insulin for 8 μg of pramlintide.
Special education pre-school services include 10-12 hours per week of special education preschool, occupational therapy, and speech and language therapy. No intensive intervention is provided.