anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study attempted to compare the prognostic performance of lymph node ratio (LNR) staging system with different cutoff values relative to American Joint Committee on Cancer (AJCC) pN staging system in stage III colorectal cancer (CRC). Overall, 45,069 patients from the SEER dataset and 69 patients from the Second Affiliated Hospital of Nanjing Medical University (the External set) who underwent surgical resection of the primary tumor and were diagnosed with stage III CRC by postoperative pathology were included. Patients were divided into three subgroups based on the LNR cutoff used in previous studies, Kaplan-Meier curves were plotted, and log-rank test was used to compare the differences among groups in terms of cancer-specific survival (CSS). Cox regression model was applied for survival analysis. To evaluate the discriminatory power of different lymph node staging systems, Harrell's C statistic(C-index) and Akaike's Information Criterion (AIC) were applied. A set of optimal cutoff values (0.11; 0.36; 0.66) of LNR staging system with the most considerable discriminatory power to the prognosis in patients with stage III CRC (SEER set: C-index = 0.714; AIC = 58,942.46, External set: C-index = 0.809; AIC = 164.36) were obtained, and both were superior to the AJCC pN staging system (SEER set: C-index = 0.708; AIC = 59,071.20, External set: C-index = 0.788; AIC = 167.06). For evaluating the prognostic efficacy of patients with stage III colorectal cancer, the cutoff value (0.11; 0.36; 0.66) of LNR staging system had the best discrimination and prognostic ability, which was superior to LNR staging system under other cutoff values and AJCC pN staging system.
PURPOSE: Graves' disease (GD) is an auto-immune cause of hyperthyroidism. First-line treatment often consists of a 12-18 month course of antithyroid drugs (ATD). After discontinuation of ATD, GD relapses in approximately 50% of patients. The 'Graves recurrent event after therapy+ ' (GREAT+) score may predict individual relapse chances after ATD discontinuation more accurately based on clinical and laboratory parameters at diagnosis. We investigated the need for the GREAT+ score through an online questionnaire among GD patients and physicians treating GD.
METHODS: An anonymous online questionnaire was distributed to patients and physicians between June 2022 and August 2023.
RESULTS: The questionnaire was completed by 532 patients and 44 physicians. Results showed that 94% of patients were interested in knowing their GREAT+ score at the start of treatment. 55% would consider definite treatment (radioiodine/thyroidectomy) as first-line treatment in case of a high relapse chance. 98% of the physicians indicated the GREAT + score would support patient counseling. 84% may change their advice for first-line treatment if a patient has a high relapse chance based on the score.
CONCLUSION: Patients and physicians considered the GREAT+ score as a valuable addition to the current available information which could change treatment decisions. Therefore, external validation of the GREAT+ score is justified to implement this score in clinical practice.
Cystic fibrosis (CF), the most common autosomal recessive disorder in Western countries, is caused by mutations of the cystic fibrosis transmembrane conductance regulator molecule (CFTR) and affects approximately 40.000 patients in Europe. The majority of CF patients develop chronic pulmonary infections with Pseudomonas aeruginosa. These are normally treated with single antibiotics, administered orally, intravenously or inhalatively. Once the infection becomes chronic, eradication of the pathogen is not any more possible due to biofilm formation of the pathogen and increasing resistance. However, inhalative antibiotic combination therapy might be more efficient than single antibiotic therapy in chronically infected CF patients. This notion is supported by previous in vitro and animal studies using Tobramycin/Colistin combination therapy. Importantly, a pilot study in five CF patients who inhaled consecutively Colistin and Tobramycin solutions for 4 week, revealed a decrease of log10 2.52 ± 2.5 cfu of P. aeruginosa in sputum specimens during the course of the treatment compared to baseline values (p=0.027). The treatment was shown to be safe and well tolerated. However, forced expiratory volume in 1 sec (FEV1) did not differ significantly.

Taking advantage of the new development of dry powder inhalation (DPI) antibiotics, specifically TOBI© Podhaler, a larger randomised trial has been performed in which the combined TOBI© Podhaler and Colistin treatment is compared to the monotherapy with Colistin.
The present invention discloses external-application medicine for treating lipsotrichia and a preparing method thereof. The external-application medicine comprises the following elements calculated by weight portions: solid powder of sodium bicarbonate, the solid powder of heavy magnesium carbonate, the solid powder of lead-acid bismuth, licorice powder, talcum powder, safflower oil, etc. Lipsotrichia is easy to diagnose and is difficult to cure. The external-application medicine for treating lipsotrichia of the present invention does not need massage treatment or the match of the administration of other medicine. The external-application medicine for treating lipsotrichia has the advantages of portability and convenient use. If the external-application medicine for treating lipsotrichia is smeared thrice every day, hair can grow after a half month. The product has the functions of generating energy for nourishing blood, nourishing the blood, promoting blood circulation, and nourishing the blood for growing the hair, and can be used without the tabu of diets.
Human cytomegalovirus (HCMV) is the most common medically significant infection in transplant patients. HCMV is usually a serious and even fatal infection in newborn SCID infants requiring hematopoietic stem cell transplant. HCMV is also the leading cause of congenital viral infection, with an incidence in the United States of 1-3% of live births. Primary HCMV infection during early pregnancy poses a 30-40% risk of intrauterine transmission. Approximately 10-15% of congenitally infected infants are symptomatic, presenting with intrauterine growth restriction and permanent birth defects, including neurological deficiencies, retinopathy, and sensori-neuronal deafness; of the infected but asymptomatic infants, 15-20% will later develop permanent sequelae. Trellis Bioscience is developing TRL345, a fully human monoclonal antibody that has specificity to the AD-2 site I in gB of HCMV, both for transplant patients and for the prevention of maternal HCMV infection during pregnancy.

Antibody therapy provides an alternative to antiviral drugs with an expectation of qualitatively lower toxicity. The leading small molecule antiviral effective against HCMV, ganciclovir (and its oral prodrug formulation valganciclovir), has side effects (including neutropenia, nephrotoxicity, and potential mutagenicity) that make its use problematic for major indications, including congenital transmission or the early post-transplant period for HCT. Although the recently approved small molecule antiviral letermovir has reduced neutropenic activity and is therefore useful in hematopoietic cell transplantation (HCT), it has not eliminated CMV reactivation in adult HCT patients.
Described herein are systems and methods for the detection and monitoring of delirium in a subject. Other neurological conditions may also be detected and monitored. The systems may include a data module configured to obtain a plurality of electroencephalography (EEG) signals collected from a subject. The systems may also include a processing module in communication with the data module. The processing module may be configured to process the data to detect and monitor delirium and/or one or more other neurological conditions that the subject is experiencing or likely to experience. The processing module may also generate indications or assessments for delirium and/or for each neurological condition at an individual level, or optionally, between two or more related neurological conditions.
Lung fibrosis is a dysregulated repair process caused by excessive deposition of extracellular matrix that can severely affect respiratory function. Macrophages are a group of immune cells that have multiple functions and can perform a variety of roles. Lung fibrosis develops with the involvement of pro-inflammatory and pro-fibrotic factors secreted by macrophages. The balance between M1 and M2 macrophages has been proposed to play a role in determining the trend and severity of lung fibrosis. New avenues and concepts for preventing and treating lung fibrosis have emerged in recent years through research on mitochondria, Gab proteins, and exosomes. The main topic of this essay is the impact that mitochondria, Gab proteins, and exosomes have on macrophage polarization. In addition, the potential of these factors as targets to enhance lung fibrosis is also explored. We have also collated the functions and mechanisms of signaling pathways associated with the regulation of macrophage polarization such as Notch, TGF-β/Smad, JAK-STAT and cGAS-STING. The goal of this article is to explain the potential benefits of focusing on macrophage polarization as a way to relieve lung fibrosis. We aspire to provide valuable insights that could lead to enhancements in the treatment of this condition.
The Pre-trained group (Group 2) will receive the exact same information as Group 1 on how to optimally perform the ORSI chicken anastomosis task but they are not required to study the material to a pre-defined proficiency benchmark. The time they spend on the task and effort expended will be logged. Once the online course is completed, participants have to perform the orsi chicken anastomosis task.
Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammation. However, the relationship between intestinal microbiota metabolites and the circadian rhythm of the intestinal barrier was still unclear. Urolithin A (UA), a kind of intestinal microbial metabolite, was selected in this study. Results showed UA influenced on the expression rhythm of the clock genes BMAL1 and PER2 in intestinal epithelial cells. Furthermore, the study investigated the effects of UA on the expression rhythms of clock genes (BMAL1 and PER2) and tight junctions (OCLN, TJP1, and CLND1), all of which were dysregulated by inflammation. In addition, UA pre-treatment by oral administration to female C57BL/6 mice showed the improvement in the fecal IgA concentrations, tight junction expression (Clnd1 and Clnd4), and clock gene expression (Bmal1 and Per2) in a DSS-induced colitis model induced using DSS treatment. Finally, the Nrf2-SIRT1 signaling pathway was confirmed to be involved in UA's effect on the circadian rhythm of intestinal epithelial cells by antagonist treatment. This study also showed evidence that UA feeding showed an impact on the central clock, which are circadian rhythms in SCN. Therefore, this study highlighted the potential of UA in treating diseases like IBD with sleeping disorders by improving the dysregulated circadian rhythms in both the intestinal barrier and the SCN.
Participants newly diagnosed with depression will be presented with a series of sugar solutions of 9 different concentrations in pseudo-random order. The threshold at which each participant reliably detects the sugar taste is determined before and after a first antidepressant. Mood Questionnaires will be used to determine whether a participant is clinically depressed at the time of the taste test and 6 to 8 weeks later.
An apparatus for refilling an implanted delivery device has a needle connected to an output port of a three-way valve. One input port is sealed and the other is connected to a fluid source. When the valve is in a fluid delivery position, fluid from the fluid source flows through the needle, and when the valve is in a stylet insertion position, fluid from the fluid source is prevented from flowing through the needle. When the valve is in the stylet insertion position, a stylet can be inserted through the second input port and into the lumen of the needle, thereby occluding the needle's lumen. In this configuration, a practitioner inserts the needle with stylet therein into the body of the patient to engage the devices's refill port. The stylet is removed, the fluid delivery path is opened, and medication is delivered to the device's reservoir without being contaminated with tissue.
The use of home preoperative chlorhexidine wash has been used in various surgical fields for the prevention of perioperative infections. However, it's use in shoulder surgery has not been published up to this point. The shoulder has a unique microbial flora due to the prevalence of Propionibacterium acnes, a bacteria implicated in surgical site infections after shoulder surgery. This study is designed to examine the efficacy of using a preoperative Sage 2% chlorhexidine cloth in reducing bacterial load in the pre-operative area as well as in reducing post-operative surgical site infections after shoulder surgery. This study will compare the rate of post-operative infections and also the rate of positive skin cultures. The skin cultures will be obtained in the preoperative area from subjects who used the Sage 2% Chlorhexidine cloth protocol pre-operatively (n=50) versus those who used only soap and water (n=50).
OBJECTIVE: To determine the rate of delivery within 15 days of admission among patients with an asymptomatic short cervix (ASC) compared to those admitted for threatened preterm labor (TPL).
MATERIAL AND METHODS: This retrospective study conducted in a tertiary maternity hospital, included patients with a singleton pregnancy admitted with a cervical length of less than 25 mm between 24 and 34 weeks. The population was divided into two groups, patients with ASC (i.e., with no contractions at admission) and patients with TPL. The primary outcome was the delivery rate within 15 days of admission. Secondary outcomes included gestational age at delivery, preterm delivery rate before 37°/7 weeks and before 34°/7 weeks, admission to delivery interval, 5 min Apgar score and transfer to neonatal intensive care unit rate. The characteristics of the two groups and the primary and secondary outcomes were compared between the two groups using univariate analysis. Two subgroup analysis were performed, one restricted to patients with a mildly modified CL (15 ≤ CL < 25 mm), and one excluding patients at high risk of preterm birth.
RESULTS: Among the 247 included patients, 136 (55.1 %) had TPL, and 111 (44.9 %) ASC. There were no significant differences in the rate of patient who delivered within 15 days of admission between the groups, 13.2 % in the TPL group vs 8.0 % in the ASC group (p = 0.22). Patients in the TPL group had a significantly higher frequency of delivery before 34 weeks compared to those in the ASC group (19.9 % versus 9.0 %, p = 0.02 This finding persisted in the subgroup analysis excluding patients at high risk of preterm birth (16.5 % in the TPL subgroup vs. 6.9 % in the ASC subgroup, p = 0.04). There were no significant differences in the rates of preterm delivery before 37 weeks, the admission-to-delivery interval, or neonatal outcomes between the two groups or within the subgroup analyses.
CONCLUSION: The frequency of delivery within 15 days of admission was not statistically different between patients with an asymptomatic short cervix and those with TPL. Nevertheless, these asymptomatic patients delivered significantly later and less frequently before 34 weeks, with only one in ten requiring corticosteroids.
The present invention provides novel vectors, compositions and methods for treating neurological disorders characterized by defective UBE 3A. It has been found that the UBE3A gene, which encodes ubiquitin ligase E6-AP, causes the Angel Syndrome (AS). A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In most cases of AS, there is a mutation or deletion in the maternally inherited UBE3A gene, but other cases are the result of either mismethylation of the maternal gene or uniparental disomy. A UBE3A protein construct was generated with additional sequences that allow secretion from the cell and uptake by neighboring neuronal cells. The UBE3A vector can be used in gene therapy to confer a functional E6-AP protein into neurons and rescue disease pathology.
The invention provides a traditional Chinese medicine preparation for treating acute diarrhea. The traditional Chinese medicine preparation comprises the following components in parts by weight: 3 parts of kudzu vine root, 2 parts of coptis chinensis, 2 parts of scutellaria baicalensis, 1 part of liquorice, 1 part of cassia twig, 2 parts of poria cocos, 2 parts of atractylodes macrocephala, 2 parts of grifola, 2 parts of rhizoma alismatis, 2 parts of rhizoma atractylodis, 2 parts of purslane, 3 pars of semen plantaginis and 3 parts of the root of Chinese pulsatilla. According to the traditional Chinese medicine preparation for treating acute diarrhea, in the formula, the kudzu vine root has the effects of relieving muscle to smooth the surface, raising yang, promoting eruption and the like, when the kudzu vine root is prepared with coptis chinensis, scutellaria baicalensis and the like in the formula, well-known kudzu vine root, coptis chinensis and scutellaria baicalensis decoction is made, with the root of Chinese pulsatilla, Chinese pulsatilla decoction is made, and the decoction is a good formula for treating heat and dampness caused diarrhea. As cassia twig can warm and remove water dampness, when the cassia twig is used with atractylodes macrocephala, poria cocos, grifola, rhizoma alismatis, rhizoma atractylodis and the like, spleen-yang can be warmed, the dampness is removed, the water is guided, and the defects that the formula is bitter and cold because of scutellaria baicalensis and coptis chinensis can be overcome. The kudzu vine root and the cassia twig both have the function of relieving exterior syndrome. Purslane and semen plantaginis are both effective components for treating diarrhea.
After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Inhibitory concentrations were achieved in the epidermis and as deep as the middle region of the dermis. Less than 1% of the applied dose was recovered in the urine and feces.

Microbiology: Econazole nitrate has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.

Econazole nitrate exhibits broad-spectrum antifungal activity against the following organisms in vitro, but the clinical significance of these data is unknown.
The invention relates to a medicament used for treating livestock virus and bacteria infections and prepared from traditional Chinese medicines. Raw material medicines including cardinal flowers, pericarpium granati, mangnolia officinalis, semen plantaginis and myrobalan are made into oral liquid or powder. The preparation method comprises the following steps of: removing impurities in the raw material medicines; frying the pericarpium granati with vinegar until the surface is yellowish-brown, and cooling the pericarpium granati; smashing the pericarpium granati fried with the vinegar, the cardinal flowers, the mangnolia officinalis, the semen plantaginis and the myrobalan; carrying out disinfection and sterilization to obtain raw material powder. Or the preparation method also comprises the following steps of: preparing the raw material medicines into a water extract according to a conventional method; preparing the water extract into the oral liquid according to a conventional method or preparing the water extract into water extract powder according to a conventional method. The medicament has reasonable compatibility, is warm but not dry, has moderate softness, has the function of strengthening the spleen and stomach, and can be widely suitable for pigeon and gallinaceous circovirus, porcine reproductive and respiratory syndrome, cough, piglet yellow, pullorosis, medium and small porcine enteritis, myocarditis and the like. The medicament prepared by pure traditional Chinese medicines has the advantages of scientific prescription, significant effect, safety and reliability, is convenient to use, has no toxic or side effect on liver, kidney, lung, stomach and spleen, and can be used for a long time.
A bacillus licheniformis/traditional Chinese medicine polysaccharide composition and preparations thereof, which are widely used in the technical field of microorganism, are disclosed. The composition comprises bacillus licheniformis, traditional Chinese medicine polysaccharides and auxiliary materials. The bacillus licheniformis relates to bacillus licheniformis CMCC63516 living bacteria powder. The weight ratio of the bacillus licheniformis CMCC63516 living bacteria powder to a traditional Chinese medicine extract product is 1:1.25-25. The traditional Chinese medicine polysaccharides are one of lycium barbarum polysaccharides, lentinan, astragalus polysaccharides, codonopsis pilosula polysaccharides, and acanthopanax senticosus polysaccharides. The polysaccharide content in the traditional Chinese medicine polysaccharides is 70-95%. In aerobic and anaerobic conditions, each traditional Chinese medicine polysaccharide has a multiplication effect for the bacillus licheniformis, and the multiplication effect of the traditional Chinese medicine polysaccharides is associated with the adding amount in a seed culture medium. The composition is prepared into an oral preparation and prepared into common tablets. The composition promotes significant multiplication of the bacillus licheniformis under aerobic and anaerobic conditions, enhances the capability of restoring intestinal flora balance, and rapidly enhances the intestinal colonization resistance. The composition is rapid to take effect and short in course of treatment when treating diarrhea and other intestine diseases.
BACKGROUND: This study aimed to investigate the utility of intensive triamcinolone acetonide (TA) injections after extensive esophageal endoscopic submucosal dissection (ESD).
METHODS: This retrospective study included 27 lesions in 27 consecutive patients who underwent ESD (ulcers encompassing ≥3/4 of the esophageal circumference) and received TA injections without oral steroid administration. Groups A and B included patients undergoing ESD with and without complete circumferential resection, respectively. All patients received TA injections (100 mg/session) immediately after ESD. In Group A, weekly based TA injections were performed until near-complete ulcer epithelialization. In Group B, patients did not receive additional injections or received weekly or biweekly TA injections. The primary outcome was stricture rate, and the secondary outcomes were the proportion of patients requiring endoscopic balloon dilation (EBD) and the number of TA injections.
RESULTS: Group A included 7 lesions, and Group B included 20 lesions. The median (range) tumor lengths were 40 (30-90) and 45 (30-110) mm in Groups A and B, respectively. In Group A, the median circumferential resection diameter was 40 (20-80) mm. The stricture rate and the proportion of patients requiring EBD were 0 (0%) in Group A and 1 (5.0%) in Group B. The number of TA injection sessions was significantly higher in Group A than in Group B (8 [5-25] vs 1.5 [1-3]; p < 0.001).
CONCLUSIONS: Intensive weekly or biweekly based TA injections might aid in preventing post-ESD stricture and the need for EBD in patients undergoing extensive resection involving the entire esophageal circumference.