anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: To introduce a novel technique of transvaginal extraperitoneal single-port laparoscopic sacrocolpopexy (ESLS) for apical prolapse and to evaluate the feasibility and short-term outcomes of this technique.
METHODS: Sixteen patients were enrolled to undergo ESLS between January 2020 and May 2021. Perioperative outcomes were included. Short-term results were assessed by Pelvic Floor Distress Inventory-20 (PFDI-20), Pelvic Organ Prolapse Quantification (POP-Q) scores, mesh exposure and prolapse recurrence.
RESULTS: A total of 14/16 cases (87.5%) were successfully completed. The mean operation time was 118 min (range 85-160), and the mean blood loss was 68 ml (range 20-100). The mean postoperative visual analog scale (VAS) pain score at 24 h was 0.7. No intraoperative complications occurred except for one patient who developed subcutaneous emphysema. All patients gained a significant improvement in both physical prolapse and quality of life at 12 months after surgery, and there was no mesh exposure or prolapse recurrence.
CONCLUSIONS: Our experience showed that transvaginal ESLS is a feasible and effective technique for apical prolapse with a previous hysterectomy. However, this technique should be performed by surgeons with extensive experience both in vaginal surgery and laparoscopic single-port surgery.
The designated health center staff will receive a web interface that will allow them to offer job aid for supervision, including real-time information about VHSGs' performance in the form of process indicators and coverage of MCH services. The tool will also support health center staff in their daily tasks, such as high-risk patient tracking, low-supply-inventory alerts, supply chain management, electronic health records, vital events tracking, and automatic calculation of performance-based incentives and motivation for VHSGs. The mobile application will be offered to two female VHSGs from each of the 200 villages connected to their respective health centers in the intervention arm. The mobile application will provide job aid to VHSGs for scheduling home visit tasks, including ANC, home-based newborn care, reporting outcomes of pregnancies, and follow-up visits of complicated cases.
Steroid-naïve asthma (randomized to 8 weeks of no inhaled corticosteroid treatment). Asthmatics not on inhaled corticosteroids, randomized to no change in treatment for 8-10 weeks. These subjects will undergo bronchoscopy and T-cell miRNA measurement at baseline and again after 8 weeks without treatment with inhaled corticosteroids.
The present invention relates to a recombinant vector for enhancing the stem cell function of neural stem cells. The neural stem cells with increased the expression and/or activity of GNG2 are completed that self-production and self-replication abilities are improved. Specifically, the present inventors confirmed that when the GNG2 recombinant vector was overexpressed in the neural stem cells obtained from a mouse fetus, the neural cell sphere-forming ability of the neural stem cells increased, and the expression of Pax6, which is a stem cell ability marker, increased. In addition, as a result of confirming the distribution of the neural stem cells in the brains after introducing the GNG2 recombinant vector into the brain of the mouse fetus, the cells expressing the recombinant vector according to the present invention were concentrated in the ventricle/subventricular zone of the cerebrum. In other words, the effect of enhancing the stem cell function of the neural stem cells by increasing the expression and/or activity of the GNG2 was confirmed both in vitro and in vivo. Therefore, the recombinant vector for enhancing the stem cell function of the neural stem cells according to the present invention is expected to be used in various fields in the treatment of traumatic encephalopathy and/or neurodegenerative diseases.
BACKGROUND/AIM: Non-steroidal anti-inflammatory drugs (NSAIDs), the most widely used pharmaceuticals, induce various adverse effects, including gastrointestinal injuries, such as ulcers and bleeding. Animal models of NSAID-induced small intestinal injury (NSI) have been extensively employed for the development of preventive and therapeutic agents. However, some experimental variations related to feeding times have been observed following NSI induction. This study aimed to investigate the impact of feeding time on an NSI mouse model.
MATERIALS AND METHODS: The mice were divided into eight groups: normal, sham, and model groups (with feeding times of 2 h, 6 h, 10 h, 14 h, 18 h, and 22 h; n=10 in each group). The mice were fasted for 18 h before the injection of indomethacin (15 mg/kg, subcutaneously), except for the normal group. Food supply was halted at specific time points (2 h, 6 h, 10 h, 14 h, 18 h, and 22 h); however, the normal and sham groups were continuously fed throughout the experiment. The length of the small intestine was measured, and histological analysis was performed 24 h after induction.
RESULTS: Up to 14 h after induction, NSI, indicated by small intestine shortening, remained consistent, with a reduction in length of approximately 10-20%. However, feeding for more than 14 h significantly exacerbated NSI, both anatomically and histologically.
CONCLUSION: The ulcerative changes observed in the small intestine 14 h after indomethacin injection may be closely associated with the influence of food on NSI.
Active cTBS will be administered with a Magventure MagPro Stimulator R30 using a butterfly coil. TBS consists of bursts of 3 pulses separated by 20ms (i.e. 50 Hz), with each triplet being repeated every 200 ms (i.e. 5 Hz). Stimulus intensities will be set at 80% of AMT. The investigators will use 2 trains of 600 pulses each separated by 1 minute (a total of 1200 pulses).
The present invention relates to methods and compositions for regulating lectin complement pathway (LCP)-associated complement activation. In particular, the invention relates to methods and compositions for inhibiting LCP-associated complement activation in order to inhibit hyperglycemic myocardial damage. The invention also relates to the treatment of cardiomyopathy and/or hypertrophy, such as cardiac hypertrophy. The invention also relates to methods and compositions for inhibiting the loss of cardiac progenitor cells by inhibiting LCP-associated complement activation. The methods include both in vitro and in vivo methods. The methods can be accomplished by contacting a mammalian cell having a surface exposed mannose binding lectin (MBL) ligand, such as a cardiac cell, with an effective amount of a MBL inhibitor to inhibit LCP-associated complement activation.
Objective: To evaluate the physical performance of women during different phases of the ovarian cycle and the influence of photobiomodulation therapy in this setting. Methods: The research will be conducted in two subprojects - Subproject I is a cross-sectional study. Initially the participants will be evaluated in two phases separately, being the first and second day within the ovarian cycle in the follicular phase (FF) and the third and fourth day in the luteal phase (FL). The aspects of body composition, body water volume and skin temperature by infrared thermography will be evaluated, and the physical performance evaluation will be constituted by the evaluation of the muscular performance by isokinetic dynamometer, and by a treadmill supramaximal effort test. , together with analysis of VO2max and blood lactate levels. Subproject II is a double-blind placebo-controlled randomized clinical trial. After completion of subproject I, during the next ovarian cycle within the participants will return to conduct the second part of the study, which will analyze the influence of photobiomodulation therapy on the physical performance of women within their menstrual cycle, related to low hormone rate ( FF). 200 J of energy will be applied before each evaluation, which is muscle performance and endurance. The tests will be performed in the same order, following the same protocol in both phases of the study. For data analysis, a normality test will be used to verify the distribution and statistical tests consistent with the appropriate intra and intergroup comparisons, being considered two factors in the comparisons, time and group. A significance level of 5% will be adopted. The effect size will be calculated by Cohens'd.
PURPOSE: A multicore-shell nanoparticle includes a manganese-magnetic nanoparticle(Mn-MNP) multicore, and is provided to have hydrophilic, non-toxic, and easy surface deformability while having high saturation magnetization(Ms) value and transverse relaxivity(R2) value. CONSTITUTION: A multicore-shell nanoparticle comprises a manganese-magnetic nanoparticle(Mn-MNP) multicore, a silica shell coating the multicore, and an antibody conjugated on the surface of the silica shell. The conjugation is formed by a click reaction between a norbornene chemical bonded with the antibody and a tetrazine chemical bonded with the silica shell. The multicore-shell nanoparticle additionally includes organic fluorescent dye inside of the silica shell. The thickness of the silica shell is 9-90 nanometers. The size of the core-shell nanoparticle is 15-100 nanometers. The Mn-MNP is existed in forms of nanoparticles inside of the silica shell, and 30-150 Mn-MNP nanoparticles form the multi-core.
Asthma is the most common chronic health condition of childhood, and continues to be associated with morbidity and mortality. Many children with persistent asthma follow a treatment plan including a prescription to take a daily inhaled corticosteroid (controller), often in conjunction with a daily oral controller medication, and a dose of an albuterol (rescue) inhaler before activity or exercise. Young people with asthma must add to this treatment plan in response to a flare in symptoms by taking additional medication and contacting their asthma provider or getting to a hospital. Adherence to daily medications is essential for maintaining lung health and reducing symptom flares, but asthma treatment is complex, requiring regular decision-making in response to symptoms and environmental issues like symptom triggers. As a result consistent adherence is a challenge for families and young people. It is recommended to provide an Asthma Action Plan (AAP) to all people diagnosed with asthma, summarizing their treatment plan using a traffic light format; Green Zone for daily, symptom-free management, Yellow Zone for symptom flare, and Red Zone for extreme symptom flare. Despite evidence for the effectiveness of AAPs, they are often not prescribed for reasons including readability and accessibility for families and young people, and asthma provider perceptions of their utility and suitability. In this study, young people with persistent asthma will be given a Written (WAAP) or Pictorial Asthma Action Plan (PAAP) to compare the differential impact on AAP knowledge, adherence to daily inhaler use, and asthma control. Software developed for the study, in collaboration with providers, young people with asthma and their parents, will be used to generate personalized PAAPs. Quantitative and qualitative data will be collected to explore perceptions of providers, parents and young people of different versions of AAPs, the influence of AAPs on asthma understanding and management, and the experience of taking part in the study, as well as to assess the impact of different AAPs on the asthma and psychosocial outcomes mentioned. The findings will inform the development of the PAAP software and as the basis for a definitive Randomized Controlled Trial of the efficacy of PAAPs.
PURPOSE:The titled complex in a solid phase obtained by supporting a substance such as protein A, etc. to be linked specifically to a Fc part of immunoglobulin on fine powder of a carrier to give a bonded substance, linking the bonded substance to an immunoglobulin molecule, which is a specific antibody. CONSTITUTION:An Fc part of an immunoglobulin molecule constituting an antibody corresponding to an antigen to be measured is linked to bonded protein A-sephalose CL4B on which a substance such as protein A, etc. is supported on fine powder of a carrier (e.g., particles insoluble in aqueous medium: polystyrene, silica, metallic powder, staphylococcus, etc.), to give a stabilized immune complex in a solid state wherein the Fc part is masked specifically and Fab or Fd site, a site of a specific antigen bond, remains in a free type. EFFECT:In the complex, an extremely small amount of antigen and antibody can be measured by a simple operation, and, especially in the antibody, anti-D activity can be measured in a level classified by class, subclass, and type of the immunoglobulin constituting the antibody.
Adult PK of Metoclopramide Hydrochloride Orally Disintegrating Tablets

In a randomized, two-arm, two-way crossover study in 44 healthy adult (male and female) fasted subjects, Metoclopramide Hydrochloride Orally Disintegrating Tablet was bioequivalent to Reglan Tablets.

In a food-effect study with 28 subjects, Metoclopramide Hydrochloride Orally Disintegrating Tablets taken immediately after a high-fat meal had a 17% lower peak blood level than when taken after an overnight fast. The time to peak blood levels increased from about 1.75 hours under fasted conditions to 3 hours when taken immediately after a high-fat meal. The extent of metoclopramide absorbed (area under the curve) was comparable whether Metoclopramide Hydrochloride Orally Disintegrating Tablets was administered with or without food. The clinical effect of the decrease in peak plasma level if Metoclopramide Hydrochloride Orally Disintegrating Tablet is inadvertently taken with food is unknown.

Adult PK of Metoclopramide

Metoclopramide is rapidly and well absorbed. Relative to an intravenous dose of 20 mg, the absolute oral bioavailability of metoclopramide is 80% ± 15.5% as demonstrated in a crossover study of 18 subjects. Peak plasma concentrations occur at about 1 to 2 hr after a single oral dose. Similar time to peak is observed after individual doses at steady state. A single dose study of 12 subjects showed that the area under the drug concentration-time curve increases linearly with doses from 20 to 100 mg (results summarized in Table 2). Peak concentrations increase linearly with dose; time to peak concentrations remains the same; whole body clearance is unchanged; and the elimination rate remains the same. The average elimination half-life in individuals with normal renal function is 5 to 6 hr. Linear kinetic processes adequately describe the absorption and elimination of metoclopramide.

Table 2: Adult Pharmacokinetic Data

Approximately 85% of the radioactivity of an orally administered dose appears in the urine within 72 hr. Of the 85% eliminated in the urine, about half is present as free or conjugated metoclopramide.

The drug is not extensively bound to plasma proteins (about 30%). The whole body volume of distribution is high (about 3.5 L/kg) which suggests extensive distribution of drug to the tissues.

The in vivo disintegration time (time reported between placing the tablet on the tongue and it completely disintegrated into fine particles) was approximately one minute (with a range of 10 seconds to 14 minutes). In the two clinical trials (N = 96) with a mean ± SD being 76.8 ± 110.6 seconds and a median of 53.5 seconds.

Renal impairment affects the clearance of metoclopramide. In a study with patients with varying degrees of renal impairment, a reduction in creatinine clearance was correlated with a reduction in plasma clearance, renal clearance, non-renal clearance, and increase in elimination half-life. The kinetics of metoclopramide in the presence of renal impairment remained linear. The reduction in clearance as a result of renal impairment suggests that reduction of maintenance dosage should be done to avoid drug accumulation.
To provide a medical skill training device that efficiently trains the skills of a responder.SOLUTION: A medical skill training device 1 is a device that performs medical skill training for training the skills of a responder who deals with a patient. A response DB 200 stores response data 210-1 to 210-n for each of inquiry item. An item selection unit 100 obtains selection results of the inquiry item and selects response data 210 of the inquiry item corresponding to the selection results stored in the response DB 200. A voice recognition unit 110 acquires a voice signal of the responder, performs voice recognition, and outputs recognition data 220. A response generation unit 120 generates the patient's response based on the response data 210 acquired by the item selection unit 100 based on the recognition data 220 voice-recognized by the voice recognition unit 110. A response output unit 130 outputs the patient's response generated by the response generation unit 120.SELECTED DRAWING: Figure 2
The invention discloses a graphene-gold nanoparticle composite carrying microRNA. The composite is prepared from three parts, namely, gold nanoparticles, microRNA and graphene, from inside to outside. The invention further discloses a preparation method of the graphene-gold nanoparticle composite carrying microRNA. The invention further discloses application of the graphene-gold nanoparticle composite carrying microRNA in preparation of a nano-drug delivery system for inducing drug-resistant ovarian carcinoma cell apoptosis in a targeted mode. The invention further discloses the nano-drug delivery system for inducing drug-resistant ovarian carcinoma cell apoptosis in the targeted mode. The nano-drug delivery system is loaded with microRNA of non-chemotherapeutic medicine, toxic and side effects are reduced, multidrug resistance is avoided, and therefore the treatment effect on drug-resistant ovarian carcinoma is improved. In addition, the nano-drug delivery system can deliver anti-cancer drugs in a targeted and release controlled mode, and a multi-element therapy for drug-resistant ovarian carcinoma is achieved through the combination with the photo-thermal therapy.
Caudal regression syndrome is a form of segmental spinal dysgenesis involving the caudal spinal column, ranging from segmental coccygeal agenesis to extensive thoracolumbar agenesis with varying degrees of spinal cord dysgenesis. A majority of caudal regression cases are sporadic but maternal pre-gestational diabetes mellitus is an important risk factor. Imaging is an integral part of management of caudal regression syndrome. Antenatal diagnosis on obstetric ultrasound and evaluation with fetal MRI is ideal. Early postnatal diagnosis and/or detailed evaluation with MRI is essential for early management to improve outcomes. Pang classification categorizes caudal regression syndrome into two categories based on the position of the conus while Renshaw classification is based on the degree of vertebral column agenesis. Caudal regression syndrome may be associated with several additional anomalies, both spinal and extraspinal. A number of genitourinary and gastrointestinal anomalies have been described in association with caudal regression syndrome. The field of view of MRI of the lumbosacral spine in caudal regression syndrome needs to be extended to visualize the retroperitoneal structures without the use of a saturation band. Syndromic associations may be suspected, and additional imaging performed, based on findings of extended field of view MRI of the spine. Associated sacral masses and filar abnormalities need to be identified and may also require surgical treatment. The multisystem nature of this disease necessitates a multimodality approach to the evaluation and management of caudal regression syndrome with close cooperation between pediatric neuroradiologists and body radiologists as well as multiple clinical teams. Appropriate early management with surgical correction as necessary can significantly improve prognosis and survival in caudal regression syndrome.
BACKGROUND: Tongue necrosis is a rare and relatively uncommon condition, usually caused by vasculitis, thrombosis, severe hypotension due to septic or cardiogenic shock, vasopressor use, or intubation. Following damage such as necrosis, dystrophic calcification, a type of soft tissue calcification, can occur.
CASE PRESENTATION: Herein, we present a unique case of bilateral tongue necrosis in a patient with nonintubated septic shock. A 70-year-old East Asian man with no significant medical history presented to the emergency department with postprandial epigastric pain. The patient was admitted to the intensive care unit with hypotension due to septic shock and disseminated intravascular coagulation. After a short course of vasopressors, the patient developed tongue discoloration and swelling without limb ischemia. Computed tomography was performed to observe the tongue necrosis, and calcification of the tongue was found. The patient was successfully treated by wiping the area with a hexamidine-soaked gauze.
CONCLUSION: Tongue necrosis remains a rare finding, and its occurrence as a complication of vasopressor use is even rarer. Therefore, even with relatively short courses of vasopressors in the intensive care unit, daily visualization of the tongue to check for discoloration, along with daily inspection and pulse checks of the limbs, can help identify vasospasms. These measures allow for prompt intervention, minimizing permanent damage and shortening the recovery time.
A dental all-ceramic restoration and manufacturing method thereof; the outer surface of the dental all-ceramic restoration has neither visible marks remaining from the removal of the connecting bars (7) nor local grinding traces and chipping, and is smooth with uniform structure. The manufacturing method thereof is wet-forming or milling. No connecting bars are needed to connect the dental restoration bodies (3) with a surrounding mould blank or ceramic blank. This eliminates the need for manually cutting off the connecting bars (7) to separate the forming body from the surrounding ceramic blank, further grinding and polishing process to treat the excessively rough outer surface, and thereby reducing the risk of chipping and premature failure. In the manufacturing processes thereof, the hardened ceramic green body (2) made by wet-forming technique has more homogenous microstructure and less particle packing defects than the dry-pressed blanks and partially sintered blanks. Furthermore, higher surface smoothness can be obtained by milling unsintered hardened ceramic green body than by milling partially sintered blanks. The dental all-ceramic restoration has a high degree of surface finish, and can be directly used without polishing, veneering or glazing.
An active gaming exercise workout will be provided with QoL measured at baseline and following the 8 week workout schedule. The workout will use the Microsoft Kinect (TM) system with EA Sports Active 2 program.
Methods and systems for controlling parameters of fluid management and medical device systems. An illustrative method may include initiating a command to acquire a plurality of data signals from a sensor of a fluid management system or a medical device at predetermined time intervals. At the time of acquisition, the data signals may be stored in a buffer until a predetermined minimum number of data signals are acquired. A plurality of data signals may be utilized to generate the curve. The curve may be filtered with an adaptive data filter configured to perform one or more passes on the curve. Each of the one or more passes of the adaptive data filter may monitor and analyze a different characteristic of the data signal, and the one or more passes may vary depending on one or more settings received from a subsystem of the fluid management system.