anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
We previously showed that knockdown or deletion of Fos downstream transcript (FosDT; a stroke-induced brain-specific long noncoding RNA) is neuroprotective. We presently tested the therapeutic potential of FosDT siRNA in rodents subjected to transient middle cerebral artery occlusion (MCAO) using the Stroke Treatment Academic Industry Roundtable criteria, including sex, age, species, and comorbidity. FosDT siRNA (IV) given at 30 min of reperfusion significantly improved motor function recovery (rotarod test, beam walk test, and adhesive removal test) and reduced infarct size in adult and aged spontaneously hypertensive rats of both sexes. FosDT siRNA administered in a delayed fashion (3.5 h of reperfusion following 1 h transient MCAO) also significantly improved motor function recovery and decreased infarct volume. Furthermore, FosDT siRNA enhanced post-stroke functional recovery in normal and diabetic mice. Mechanistically, FosDT triggered post-ischemic neuronal damage via the transcription factor REST as REST siRNA mitigated the enhanced functional outcome in FosDT-/- rats. Additionally, NF-κB regulated FosDT expression as NF-κB inhibitor BAY 11-7082 significantly decreased post-ischemic FosDT induction. Thus, FosDT is a promising target with a favorable therapeutic window to mitigate secondary brain damage and facilitate recovery after stroke regardless of sex, age, species, and comorbidity.
A special sachet formulation containing 20 meq K/sachet will be made for the study by Meta Pharm Development. The contents of a sachet will be added to 250 ml water and drunk with breakfast and dinner, to deliver 40 meq K (as citrate) per day during the Potassium Citrate Phase for 4 weeks.
In this paper, we propose Varying Effects Regression with Graph Estimation (VERGE), a novel Bayesian method for feature selection in regression. Our model has key aspects that allow it to leverage the complex structure of data sets arising from genomics or imaging studies. We distinguish between the predictors, which are the features utilized in the outcome prediction model, and the subject-level covariates, which modulate the effects of the predictors on the outcome. We construct a varying coefficients modeling framework where we infer a network among the predictor variables and utilize this network information to encourage the selection of related predictors. We employ variable selection spike-and-slab priors that enable the selection of both network-linked predictor variables and covariates that modify the predictor effects. We demonstrate through simulation studies that our method outperforms existing alternative methods in terms of both feature selection and predictive accuracy. We illustrate VERGE with an application to characterizing the influence of gut microbiome features on obesity, where we identify a set of microbial taxa and their ecological dependence relations. We allow subject-level covariates, including sex and dietary intake variables to modify the coefficients of the microbiome predictors, providing additional insight into the interplay between these factors.
Yoga exercises performed asynchronously accompanied by videos. Exercise videos will be broadcast to the participants in this group through the "YouTube program". The shooting of the exercise videos will be completed in advance and uploaded to a channel opened on YouTube. All posts made in this channel will only be open to individuals participating in the research during the duration of the study. Yoga exercises were created with reference to studies in the literature. It will be applied for 8 weeks, 3 days a week and 40-45 minutes. Participants will be able to access the exercise videos at a time they want (Table 2). Participants will be encouraged to achieve weekly targeted training sessions and to keep an exercise diary.
Biomass-related airborne fine particulate matter (PM2.5) is an important risk factor for chronic obstructive pulmonary disease (COPD). Macrophage polarization has been reported to be involved in PM2.5-induced COPD, but the dynamic characteristics and underlying mechanism of this process remain unclear. Our study established a PM2.5-induced COPD mouse model and revealed that M2 macrophages predominantly presented after 4 and 6 months of PM2.5 exposure, during which a notable increase in MMP12 was observed. Single cell analysis of lung tissues from COPD patients and mice further revealed that M2 macrophages were the dominant macrophage subpopulation in COPD, with MMP12 being involved as a hub gene. In vitro experiments further demonstrated that PM2.5 induced M2 polarization and increased MMP12 expression. Moreover, we found that PM2.5 increased IL-4 expression, STAT6 phosphorylation and nuclear translocation. Nuclear pSTAT6 then bound to the MMP12 promoter region. Furthermore, the inhibition of STAT6 phosphorylation effectively abrogated the PM2.5-induced increase in MMP12. Using a coculture system, we observed a significantly reduced level of E-cadherin in alveolar epithelial cells cocultured with PM2.5-exposed macrophages, while the decrease in E-cadherin was reversed by the addition of an MMP12 inhibitor to the co-culture system. Taken together, these findings indicated that PM2.5 induced M2 macrophage polarization and MMP12 upregulation via the IL-4/STAT6 pathway, which resulted in alveolar epithelial barrier dysfunction and excessive extracellular matrix (ECM) degradation, and ultimately led to COPD progression. These findings may help to elucidate the role of macrophages in COPD, and suggest promising directions for potential therapeutic strategies.
There is no experience with acute overdose of zolmitriptan. Clinical study subjects who received single 50 mg oral doses of zolmitriptan commonly experienced sedation.

There is no specific antidote to zolmitriptan. In cases of severe intoxication, intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.

The elimination half-life of zolmitriptan is 3 hours [see Clinical Pharmacology (12.1)]; therefore, monitor patients after overdose with zolmitriptan for at least 15 hours or until symptoms or signs resolve. It is unknown what effect hemodialysis or peritoneal dialysis has on the plasma concentrations of zolmitriptan.
PURPOSE:To provide the title novel derivative having high affinity for and specificity to delta-receptor, as a psychotropic agent effective for depression and mania etc. CONSTITUTION:The objective compound of formula I (Ar is phenyl or thienyl; n is 2-6; R is hydroxyl, etc.), e.g. 1,[3-{4-(3,4-dichlorophenyl)-1,2,5,6- tetrahydropyridine-1-yl}-propylcarbamoyl]-2-oxopyrrolidine. The present compound can be obtained by the following process: a compound of formula II is reacted with a compound of formula III in an appropriate organic solvent such as methanol or THF into a compound of formula IV, which is then dehydrated pref. in the presence of an acid.
FIELD: medicine, gynecology. SUBSTANCE: method proposes the administration of an acid fraction of electrochemically active water at pH 3.3-4.1 into uterus cavity after operation immediately and before coagulation of the uterus cavity. Administration is carried out by needle having an external diameter not above one-half of diameter of expanded cervical channel after abortion. This water is used for additional spraying the external vulva. Method ensures to optimize regenerative processes in uterus endometrium. EFFECT: enhanced effectiveness of the method. 2 cl, 2 ex
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction, cognitive impairment, and other non-motor symptoms. Here, we propose to use "Bio Electro Stimulation Therapy" (B.E.S.T.) using the "e-Tapper TT-R1"owned by Immumax International Co. Ltd., a Hong Kong based company. The "e-Tapper" is a non-invasive, handheld electronic device designed to apply micro current stimulation to a person's hand at specified points representing various body parts, such as the head, leg, or foot. This is one form of Bio Electro Stimulation Therapy, known as "11-point Hand Treatment System". The current delivered is less than one milliampere. Anecdotal evidence suggests that this micro current stimulation may reduce resting tremor, restore facial expressions, and improve ease of movement, mood, and sleep quality in patients with PD. Scientific evidence for the effectiveness of the B.E.S.T. Hand Therapy appears to be lacking in the English language (Western) literature. The goal of this pilot device feasibility study is to examine whether B.E.S.T. can increase physical activity and functional fitness, enhance cognition, improve mood and subjective sleep quality, and modulate resting tremor and gait parameters in PD patients over a 6-week period.
The intervention product was a full fat (80%) margarine. The active intervention product contained 590 mg docosahexaenoic acid (DHA) and 650 mg eicosapentaenoic acid (EPA) per 10-g daily serving.
FIELD: medicine.SUBSTANCE: method involves preliminary assessment of the reversible abnormal changes of enamel accompanying early cariosity. That is ensured by diagnostic tests of solid dental tissues conducted by using light-induced fluorescence and electrometric measurement techniques followed by therapy involving daily applications of the Radogel-GABA preparation. If observing visually detected changes with a current intensity of 0.21-1.99 mcA in the lesion and the presence of fluorescence, the preclinical changes of enamel are diagnosed requiring 5 therapeutic procedures with the above preparation. Visualised tarnishing of enamel accompanied by a current intensity of 2.00-3.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a dead spot is diagnosed, and 7 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 4.00-5.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a white spot is diagnosed, and 10 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 6.00-7.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of an intense white spot is diagnosed, and 15 therapeutic procedures with the Radogel-GABA preparation are required.EFFECT: method provides the high-effective therapeutic exposure on caries by the timely recovery of the protein dental matrix with simplicity and ease of use at massive dental visits.2 tbl
Often in emergencies and other medical situations, doctors must gain vascular access (access to the blood stream) in order to give drugs and/or fluids to patients. The most common way to gain vascular access is to place a needle into a vein through the skin, but sometimes this is not possible. Another way to gain vascular access is to insert a needle through the skin, into the bone and give drugs and/or fluids to patients through the center of the bone, which is hollow and contains blood vessels. This is called intraosseous (IO) vascular access. One device used to gain intraosseous vascular access is called the EZ-IO® Intraosseous Vascular Access System and it can be used in the proximal humerus (upper arm bone), proximal tibia (upper shin bone), and the distal tibia (lower shin bone). The EZ-IO has been cleared by the FDA to establish IO vascular access in the sites identified above for the infusion of drugs and fluids anytime vascular access is difficult to obtain in emergent, urgent, or medically necessary cases.

IV fluids and medicines must be infused into a patient's blood stream at different speeds depending upon what is being infused. Some IV fluids and medications must be given slowly and some must be given quickly. How fast IV fluids and medicines are infused into the blood stream is called infusion flow rate. One way to increase the infusion flow rate is to apply pressure to (squeeze) the IV fluid bag being used. This is done by applying a pressure bag around the IV fluid bag, which acts like a blood pressure cuff and inflates when pumped up. The purpose of this study is to see how quickly IV fluids can be infused into your blood stream through the proximal humerus (upper arm bone) and the proximal tibia (upper shin bone) by measuring the infusion flow rate. We want to see how fast IV fluids can be infused into your blood stream at different infusion pressures. We will also look at the route the fluid travels from the IO needle in your arm and leg to the heart.

Another purpose of the study is to determine if blood drawn from the bone can be used for laboratory tests the same as blood drawn from a vein or collected using a finger stick.
The invention relates to bath powder for treating neurasthenia. The bath powder is prepared by the steps of mixing 50 parts of zizyphus jujube tree roots, 35 parts of salviae miltiorrhizae, 30 parts of longspur epimedium, 30 parts of lily, 30 parts of tuber fleeceflower stem, 20 parts of coptidis rhizome, 30 parts of rhizoma sparganii, 30 parts of earthworm, 50 parts of agilawood, 25 parts of mint, 30 parts of cortex albiziae, 20 parts of radix curcumae, 45 parts of mirabilite, 20 parts of liquorice and 20 parts of polygala tenuifolia together; performing heating drying the above drugs with an intake air temperature of 180-290 DEG C and outlet air temperature of 80-90 DEG C; grinding the above drugs into powder; and subpackaging quantitatively. In the above composition, the composition can be made into 80-100 g per bag if being weighed in grams. When the bath powder is in use, the drug formula is put in bath water with stirring. The water consumption of the bath is between 80 L and 100 L; an immersing time is 1-2 hours every day; and 10 days is a course of treatment. Usually, neurasthenia is healed after three to five courses. The effective rate is 97%. The usage amount can be adjusted according to conditions of patients. The bath powder has the main functions for treating neurasthenia, intractable insomnia, disturbed consciousness and dysphoria and impatience.
The investigators surgically remove the infected implant and all soft tissue infection. Instead of a total of 2 week's of antibiotic therapy, they administer a total of 4 weeks of systemic antibiotic therapy targeted to the pathogen(s).
The investigators conducted a randomized double-blind crossover trial among 60 healthy college students in Shanghai, China from November to December, 2015. These students lived in dormitories that were randomized into two groups and alternated the use of true or sham air purifiers for 9 consecutive days with a 2-week wash-out interval. All participants and research staffs were blinded to the group assignment. All participants were required to stay in their dormitory with the windows/doors closed for at least 50% of the time on weekdays and for 80% on weekends throughout the 9-day intervention period. All interventions started at 7 a.m. to avoid issues related to diurnal variation. Health endpoints, including blood pressure, fractional exhaled nitric oxide were evaluated and biological samples such as morning urine, fast blood and buccal cells were collected at baseline and immediately after the completion of each intervention period.
PURPOSE: To provide a stick-like alum which can be fixed to an existing package. CONSTITUTION: A hole 3 in a diametral direction is formed at the stick-like alum 1 as a deodorant. A cylindrical body consisting of an elastic plastic material or rubber is arranged in this hole and lock pins or studs 4 are arranged by one piece each at both ends of this cylindrical body. These lock pins or studs 4 are brought into pressurized contact with the inside wall of a case 2 into which the stick-like alum is inserted. The stick is fixed into the case by friction. The insertion and fixation of the stick-like alum into the existing case of a standard type are made possible by using such case even if the case of a specific shape is not designed.
This is an assessment only control condition. Participants complete all of the same measures as do youth in the other two conditions at the same time points (i.e., baseline, post-intervention (about 10 weeks after baseline) and at a six-month follow-up.
Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.
This invention designs and builds multiple layers (two layers or more) of various dental devices, specifically denture base or denture, where printed multiple layered denture base with teeth cavities to receive artificial denture tooth materials to form final dental devices, such as partial and full dentures. It can also print denture teeth. This invention also designs and prints multiple layers (two layers or more) of denture base with artificial denture teeth to form final dental devices, such as partial and full dentures. Methods and materials are provided for printing a denture base and/or artificial denture teeth comprised of multiple layers. Highly shape adjustable or shape memory polymer layer(s) may be used in these multiple layered denture base forms. Different layer of material has different mechanical and physical properties to meet different need, which provide added benefits to the patients, dental professional and dental laboratory.
BACKGROUND: In recent years, various robotic systems specifically designed for microsurgical tasks have been developed and approved. There is not much evidence for these systems to date. In our study, we examined the use of robot-assisted microsurgery in the reconstruction of the lower extremity.
PATIENTS/MATERIAL AND METHODS: Data was prospectively collected between February and November 2023. The Symani robotic system was used in 42 robot-assisted microsurgical procedures on the lower extremity, and the results were evaluated and documented.
RESULTS: The average age of the patients was 57±18 years. A total of 39 free flap reconstructions (95%), one lymphatic surgical procedure (3%) and two nerve transfers (5%) were performed. In total, 46 anastomoses and coaptations were carried out. This included six arterial end-to-end anastomoses (11%), seven arterial end-to-side anastomoses (13%), 36 venous end-to-end anastomoses (65%), two lymphovenous anastomoses (4%), and five epineural coaptations in the context of nerve transfers (9%). Arterial end-to-end anastomoses took an average of 26±12 minutes, and arterial end-to-side anastomoses took 42±21 minutes. The venous anastomoses took an average of 33±12 minutes. Epineural coaptations took an average of 24±13 minutes. In no procedure was there a need for a conversion to conventional hand suturing. There were two arterial thromboses (5%), one of which was successfully revised to save the flap. One total flap loss occurred, but there were no partial flap losses.
CONCLUSION: Using the Symani robotic system for microsurgical reconstruction of the lower extremity, we were able to demonstrate results that are comparable to conventional microsurgery.
<P>PROBLEM TO BE SOLVED: To provide a composition remarkably promoting equol production.  <P>SOLUTION: The composition contains, as active ingredient, lactobionic acid, a salt thereof or lactobionolactone. Food/drink, feed, pet food or pharmaceuticals, each containing the composition, are also provided, respectively. This composition has the effects of preventing/treating osteoporosis, increasing bone density and preventing breast cancer and prostatic cancer, and has hypocholesterolemic activity. This composition, when compounded in pharmaceuticals or food/drink, takes effect of preventing vascular diseases owing to its hypocholesterolemic activity, preventing breast cancer and prostatic cancer, and preventing and/or treating osteoporosis. Besides, this composition, when compounded in feed and pet food, increases bone density and takes effect of preventing swine leg weakness and strengthening laying hens' eggshells, preventing osteoporosis of dogs or the like, etc.  <P>COPYRIGHT: (C)2008,JPO&INPIT
PROBLEM TO BE SOLVED: To provide chronic pain therapeutic agents for alleviating chronic pain effectively.SOLUTION: Chronic pain is alleviated by a REV-ERB agonist. Chronic pain is involved in hyperexcitability of spinal cord glia cells, and a drug which controls the activity of a clock gene REV-ERB present in spinal cord glia cells serves as an analgesic. A REV-ERB agonist is e.g. SR9009. When the REV-ERB agonist SR 9009 was administered to the spinal of a neuropathic pain model intrathecally, an effect of alleviating the pain in a dose-dependent manner was observed after 3 hours. Even if SR9009 was administered to the control group, the threshold value of the pain was not affected.SELECTED DRAWING: Figure 1
BACKGROUND: The Nimbus stent-retriever (NSR) was developed for mechanical thrombectomy of wall-adherent thrombi in cerebral arteries. It features a novel geometry with a proximal spiral section and a distal barrel section. The new device is designed to retrieve tough clots with a micro-clamping technique. In the first case series reporting on the NSR, we share our initial experience about the first 12 treated cases.
METHODS: In total, 12 patients (5 men, 7 women; mean age 78 years) with occlusion of the internal carotid artery or the middle cerebral artery (M1 or M2 segment) were treated with the NSR, 11 after unsuccessful recanalization attempts with conventional stent-retrievers or aspiration thrombectomy.
RESULTS: Retrieving maneuvers with the NSR recovered a thrombus in 7 patients (58%), of which 6 resulted in vessel recanalization mTICI ≥ 2b. Successful recanalization improved the mTICI score by a median of 3 points. In 5 of 7 cases, this required only one thrombectomy maneuver. In 5 cases, no improvement of recanalization could be achieved with the NSR (1-3 attempts). No NSR-related complications occurred in this case series.
CONCLUSIONS: In our initial experience, the NSR appeared to be a safe and effective second-line stent-retriever after unsuccessful MT with conventional stent-retrievers or aspiration thrombectomy allowing for mTICI ≥ 2b rescue thrombectomy in ab 50% of cases. No NSR associated complications occurred in our case series.