anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Ulcerative colitis (UC) is a serious health problem with increasing morbidity and prevalence worldwide. The pathogenesis of UC is complex, currently believed to be influenced by genetic factors, dysregulation of the host immune system, imbalance in the intestinal microbiota, and environmental factors. Currently, UC is typically managed using aminosalicylates, immunosuppressants, and biologics as adjunctive therapies, with the risk of relapse and development of drug resistance upon discontinuation. Therefore, further research into the pathogenesis of UC and exploration of potential treatment strategies are necessary to improve the quality of life for affected patients. According to previous studies, Lactobacillus paracasei Jlus66 (Jlus66) reduced inflammation and may help prevent or treat UC.
METHODS: We used dextran sulfate sodium (DSS) to induce a mouse model of UC to assess the effect of Jlus66 on the progression of colitis. During the experiment, we monitored mouse body weight, food and water consumption, as well as rectal bleeding. Hematoxylin-eosin staining was performed to assess intestinal pathological damage. Protein imprinting and immunohistochemical methods were used to evaluate the protein levels of nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and tight junction (TJ) proteins in intestinal tissues. Fecal microbiota was analyzed based on partial 16S rRNA gene sequencing.
RESULTS: Jlus66 supplementation reduced the degree of colon tissue damage, such as colon shortening, fecal occult blood, colon epithelial damage, and weight loss. Supplementation with Jlus66 reduced DSS-induced upregulation of cytokine levels such as TNF-α, IL-1β, and IL-6 (p < 0.05). The NF-κB pathway and MAPK pathway were inhibited, and the expression of TJ proteins (ZO-1, Occludin, and Claudin-3) was upregulated. 16S rRNA sequencing of mouse cecal contents showed that Jlus66 effectively regulated the structure of the intestinal biota.
CONCLUSION: In conclusion, these data indicate that Jlus66 can alter the intestinal biota and slow the progression of UC, providing new insights into potential therapeutic strategies for UC.
Serrated lesions are common precancerous pathways in colorectal cancer (CRC), but the process by which they progress to malignancy remains unclear. We aimed to elucidate this progression through a single-cell RNA landscape. We conducted single-cell RNA sequencing on three normal colonic tissues and fifteen SLs (including HPs, SSLs, SSLD, and TSAs) and integrated these data with datasets containing tumor samples. We identified three invasive malignant epithelial cell subtypes related to CRC progression: SLC1, SLC2, and tumor cell. SLC1, specific to SSLs, is involved in cell proliferation and shows a continuum of malignancy in gene expression. TSA-specific SLC2 exhibited FOXQ1 upregulation and active EMT, indicating invasiveness. The trajectory analysis showed that HPs do not progress to cancer, and different SL types are linked to the MSI status of advanced CRCs. We validated molecular drivers in premalignant lesions and later carcinogenesis. In the tumor microenvironment, CAF and pre-CAF fibroblast subtypes associated with progression were identified. During the premalignant stage, SLC1 triggered CD8+ T cell responses, while at the advanced stage, CAFs promoted tumor invasion and metastasis via FN1-CD44, influencing tumor progression and the treatment response. Our findings highlight transcriptional changes across serrated pathway stages, aiding in early CRC diagnosis and treatment.
Recurrent laryngeal nerve (RLN) palsy is the most common and serious complication after thyroid surgery, and ranks among the leading reasons for medicolegal litigation of surgeons. Intraoperative neuromonitoring (IONM) are being applied to prevent RLN injury during thyroid surgery. IONM has been used as a means not only to localize and identify the RLN, but also to predict cord function and elucidate the surgical pitfalls during preparation of RLN.

Muscle relaxant is necessary for general anesthesia; it can facilitate tracheal intubation and stable conditions for surgery. However, the use of muscle relaxant might diminish the EMG response during IONM and interfere with the interpretation of IONM results. Eighty patients were randomized to receive one (group 1, n=40) or two (group 2, n=40) effective dose (ED95) of rocuronium to facilitate EMG endotracheal tube insertion. Evoked potentials were obtained per 5 minutes by stimulating vagus nerve from the time point of 30 to 70 minutes after administration of rocuronium. The magnitude of evoked potential at each time point and tracheal intubating condition were compared between groups. Accelerometry \[twitch (% TW)\] was used to monitor the quantitative degree of neuromuscular transmission. The aim of this study was to explore an alternative non-depolarizing muscle relaxant (Rocuronium) and its optimal dosage to replace succinylcholine for IONM. The ED95 of rocuronium is 0.3mg/kg and 2×ED95 is generally recommended as a standard intubation dosage.
Multiple doses of QBW251 750 mg qd in Healthy Volunteers. 14-day treatment period, follow-up study visits (Days 18, 22 and 29) and one End-of-Study evaluation (Day 36).
Individually, metabolic variations can significantly influence predisposition to obesity in the form of the obesity-prone (super-responders) and obesity-resistant (non-responders) phenotypes in response to modern calorie-dense diets. In this study, C57BL/6J mice (n = 76) were randomly assigned to either a low-fat diet (LFD) or a high-fat diet (HFD) for 6 weeks, followed by selection of the normally obese (HFD), non-responders (NR), super-responders (SR), or super-responders switched back to the low-fat diet (SR-LFD) for an additional 8 weeks. SR mice showed the highest gains in body weight, lean and fat body mass, and total and free water, in part due to increased feed efficiency, despite having a respiratory exchange ratio (RER) similar to that of NR mice. A switch to the LFD was sufficient to revert most of the observed physiological changes in the SR-LFD mice; however, voluntary physical activity and exercise capacity did not return to the basal level. NR mice showed the highest food intake, lowest feed efficiency, increased oxygen consumption during the light (rest) cycle, increased physical activity during the dark (active) cycle, and increased heat production during both cycles. These variations were observed in the absence of changes in food intake and fecal parameters; however, NR fecal lipid content was lower, and the NR fecal microbiome profile was characterized by reduced abundance of Actinobacteria. Taken together, our findings suggest that NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study. These findings underscore the need for further comprehensive investigations into the mechanisms of obesity resistance, as they hold potential implications for weight-loss strategies in human subjects.
Dermatoses are an increasingly common problem, particularly in developed countries. The causes of this phenomenon include genetic factors and environmental elements. More and more scientific reports suggest that the gut microbiome, more specifically its dysbiosis, also plays an important role in the induction and progression of diseases, including dermatological diseases. The gut microbiome is recognised as the largest endocrine organ, and has a key function in maintaining human homeostasis. In this review, the authors will take a close look at the link between the gut-skin axis and the pathogenesis of dermatoses such as atopic dermatitis, psoriasis, alopecia areata, and acne. The authors will also focus on the role of probiotics in remodelling the microbiome and the alleviation of dermatoses.
To evaluate the association of standardized phase angle (SPA) with nutritional status, functional parameters, and postoperative outcomes in surgical cancer patients. This prospective study includes 59 cancer patients from Pelotas (Brazil) admitted for elective cancer surgery. We obtained the phase angle through Bioelectrical Impedance Analysis (BIA) and standardized it according to the population's reference values. We estimated the muscle mass using BIA for later calculation of the Skeletal Muscle Index (SMI) and performed handgrip strength (HGS) and gait speed (GS) tests. We used the Patient-Generated Subjective Global Assessment (PG-SGA) to assess the nutritional status. Postoperative complications and duration of hospital stay were evaluated as the outcomes. The prevalence of malnutrition in the sample was 28.8%, according to ASG-PPP. SPA was statistically lower in patients with malnutrition, with lower HGS and reduced GS. For postoperative outcomes, patients with severe complications and those with prolonged hospitalization also had lower SPA values. The greater the number of functional alterations in patients, the lower the SPA value, mainly when associated with reduced muscle mass assessed by BIA, suggesting that muscle mass reduction plays an important role in the association between functional alterations and phase angle in patients with cancer. According to the parameters used in this study, low SPA value was associated with impaired nutritional and functional status and negative outcomes in the analyzed sample.
PURPOSE:To obtain a cyclic inulooligosaccharide deriv. which, having a high solubility in an org. solvent, is widely applicable in the fields where its clathrate action is utilized and in the fields of food, medicines, cosmetics, catalysts, and separation and purification. CONSTITUTION:The deriv. is obtd. by the sulfonylation, dehydration, dehydration and alkylation, or sulfhydrylatin of at least one hydroxyl group of a cyclic inulooligosaccharide of the formula (wherein n is an integer of 6-8).
BACKGROUND AND PURPOSE: Caveolin-1 (Cav-1) is reported to mediate blood-brain barrier integrity after ischaemic stroke. Our purpose was to assess the role of circulating Cav-1 levels in predicting symptomatic intracranial haemorrhage (sICH) amongst ischaemic stroke patients after endovascular thrombectomy (EVT).
METHODS: Patients with large-vessel occlusive stroke after EVT from two stroke centres were prospectively included. Serum Cav-1 level was tested after admission. sICH was diagnosed according to the Heidelberg Bleeding Classification.
RESULTS: Of 325 patients (mean age 68.6 years; 207 men) included, 47 (14.5%) were diagnosed with sICH. Compared with patients without sICH, those with sICH had a lower concentration of Cav-1. After adjusting for potential confounders, multivariate regression analysis demonstrated that the increased Cav-1 level was associated with a lower sICH risk (odds ratio 0.055; 95% confidence interval 0.005-0.669; p = 0.038). Similar results were obtained when Cav-1 levels were analysed as a categorical variable. Using a logistic regression model with restricted cubic splines, a linear and negative association of Cav-1 concentration was found with sICH risk (p = 0.001 for linearity). Furthermore, the performance of the conventional risk factors model in predicting sICH was substantially improved after addition of the Cav-1 levels (integrated discrimination index 2.7%, p = 0.002; net reclassification improvement 39.7%, p = 0.007).
CONCLUSIONS: Our data demonstrate that decreased Cav-1 levels are related to sICH after EVT. Incorporation of Cav-1 into clinical decision-making may help to identify patients at a high risk of sICH and warrants further consideration.
The safety and efficacy of maraviroc have been established in pediatric patients aged from aged 2 to less than 18 years. The use of maraviroc in pediatric patients was supported by pharmacokinetic and safety data described below and by previous demonstration of efficacy in adult patients [see Indications and Usage (1)], Dosage and Administration ( 2.4)] .   
HIV-1–Infected Pediatric Patients Aged 2 to Less Than 18 Years: The safety, pharmacokinetic profile, and antiviral activity of maraviroc were evaluated in treatment-experienced, CCR5- tropic, HIV-1–infected pediatric subjects aged 2 to less than 18 years weighing at least 10 kg in an open-label, multicenter clinical trial, A4001031 [see Adverse Reactions ( 6.1), Clinical Studies ( 14.2)]. Pharmacokinetics were evaluated in a total of 98 pediatric subjects: 85 subjects received maraviroc and concomitant medications that included potent CYP3A inhibitors with or without potent CYP3A inducers, 10 subjects received maraviroc and noninteracting medications (not containing potent CYP3A inhibitors or potent CYP3A inducers), and three subjects received maraviroc and medications that included potent CYP3A inducers without potent CYP3A inhibitors [see Clinical Pharmacology ( 12.3)].    
There are insufficient data to make dosing recommendations for use of maraviroc in pediatric patients concomitantly receiving potent CYP3A inhibitors and weighing less than 10 kg, or in any pediatric patients concomitantly receiving potent CYP3A inducers without a potent CYP3A inhibitor [see Dosage and Administration ( 2.4, 2.5)].    
Maraviroc is not recommended in pediatric patients weighing less than 10 kg.
PURPOSE: To obtain a gelatinized product which is formed by gelatinizing starch without using a high pressure and imparts excellent gustatory sensation and color characteristics to confectionery by mixing pregelatinized high-amylose starch, sweetener, etc., at specific ratios, heating and dispersing the mixture and extruding the mixture as a rigid gel by a kettle extruder. CONSTITUTION: The fluid mixture is prepd. by mixing (A) 10 to 90% (in 100wt.% dry solid) blend obtd. by compounding modified starch consisting of the spray dried pregelatinized high-amylose starch (e.g.: amylose starch consisting of high-amylose corn hybrids and contg. at least 40wt.% amylose) or high-amylose starch and other derived starch up to 8 pts.wt. (in 10 parts total weight), (B) 70 to 90% sweeteners and (C) 0 to 20% water and heating the mixture up to 93 deg.C. This mixture is put into the kettle extruder and is heated and dispersed at 93 to 149 deg.C and the dispersion is extruded as the solidified gel from the kettle extruder, by which the desired product is obtd.
A system for regulating the expression of a gene in a eukaryotic cell is provided, in which the expression of a desired gene can be activated or deactivated according to deliberate intentions (i.e., via an inducible signal) and in which regulation of gene expression occurs at the level of translation of the gene. This regulation is accomplished by, first, the introduction of at least one mutation into the coding sequence of the gene of interest. This mutation(s) causes a decrease or alteration of translation, and, hence, a decrease or alteration of expression of the desired gene. The method of the invention further involves contacting the eukaryotic cell containing the now mutated gene of interest with an agent that is able to suppress the effect of the mutation, thus allowing translation, and, hence, expression of the desired gene. Preferably, the method involves introduction of a stop codon mutation, which is suppressed by an aminoglycoside. Nucleic acid compositions for use in the system of the invention, and kits for carrying out the methods of the invention, are also provided.
Invasive monitoring is a common method used in intensive care units to measure cardiovascular status. These parameters include central venous pressure (CVP), pulmonary artery pressure (PAP) cardiac output (CO) and arterial blood pressure (BP). There is a general understanding that these parameters vary with the position of the patient with the expectation that, as the patient goes from supine to sitting, these parameters decrease to some extent due to decreased venous return to the heart. Furthermore, the extent to which a patient might be reclining in bed can vary greatly from just having the head slightly raised to being totally upright. Different policies exist with respect to patient position when these measurements are made. The policies vary from no specified position to placing them completely flat for making the measurement and then returning them to a more upright position, usually 30 or 45 degrees. Decisions are based upon the supine measurements despite no clear correlation to the patient's usual position. This study will investigate the correlation between position and these parameters.

Patients in the HVICU will be approached by a member of the research team and asked for their verbal approval to record measurements made by their nurse. After receiving verbal consent to record the measurements, a member of the study team will record BP. CVP, PAP and CO as measured by the patient's nurse. These measurements will be recorded with the patient lying on the bed with the back of the bed raised to 30o and with the patient supine when the back of the bed is at 0o. The transducers will be leveled with the anterior axillary by zeroing of the transducer. After each position change, the team member will ask the nurse to wait 5 minutes to allow stabilization of these parameters before measuring and recording the parameters at that position. These parameters will be recorded on an hourly basis using the day for as many days as the required measurements are being made for clinical care. Other patient information recorded will be date, ejection fraction, BMI, height, weight, age, and PEEP, if the patient is intubated.

Sixty patients between 18 and 85 years of age will be recruited in HVICU by means of convenience sampling. The sample size was calculated based on the initial measurement of CVP where our preliminary data shows a mean difference 1.28±2.93 mmHg, and assuming that values with a difference \< 3 are equivalent, with an α = 0.05 and a power of 90. The calculation was done at the following website: http://www.sealedenvelope.com/power/continuous-equivalence. Data will be analyzed using a test of equivalence on the initial measurements (test of equivalence between two means) and then over time (repeated measurements) with a linear mixed-effects model.
Laryngeal microsurgery is mainly performed by a conventional method of general anesthesia with endotracheal intubation (ET), which may have difficulty accessing the lesion behind the larynx, and may be limited in securing space for surgical manipulation. To compensate for these shortcomings, a method of maintaining general anesthesia without using an endotracheal tube has been introduced, and high-flow nasal oxygen(HFNO) and transnasal humidified rapid insufflation ventilatory exchange(THRIVE) enable tubeless anesthesia due to apnea oxygenation and apnea ventilation effect during laryngeal microsurgery. Coughing and straining can be accompanied by emergence after general anesthesia. Forceful vocal cord adduction especially after upper respiratory surgery such as laryngeal microsurgery can cause damage and bleeding of surgical tissue, delaying wound healing. If a small amount of remifentanil is continuously injected during emergence after total intravenous anesthesia(TIVA), airway complications such as coughing can be reduced during emergence without delay in recovery time, and hemodynamic stability can be promoted. In this study, the effect of endotracheal intubation and high-flow nasal oxygen on the emergence cough and postoperative sore throat is compared when total intravenous anesthesia(TIVA) using propofol and remifentanil is performed in patients undergoing laryngeal microsurgery. This study hypothesizes that in general anesthesia for laryngeal microsurgery, high-flow nasal oxygen without endotracheal intubation reduces cough during the emergence period compared to endotracheal intubation.
All COPD patients living in the southern part of Rogaland county in Western Norway, with a habitual value of FEV1 \< 50%, who were monitored at home by TVC following discharge after emergency hospitalization for COPD exacerbation at Stavanger University Hospital, or who had tele-monitoring at home under outpatient treatment for acute COPD deterioration during the pilot project period (16th April 2010 - 31st December 2011). The telemedicine equipment consisted of a computer with a web camera with a microphone, through which the patient at home and the specially trained nurse in hospital were able to communicate, and also comprised requisites to measure the patient's oxygen saturation and heart rate, and to perform a spirometry.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to cosmetology. The inventive subject matter is a keratin fibre dyeing composition containing at least 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-one as a first oxidising base, p-toluylenediamine or p-phenylenediamine as a second oxidising base, and substituted m-aminophenol of specified formula as a first condensation ingredient, bearing in mind that the mole ratio of the first condensation ingredient to the first oxidising base exceeds 1, while the mole ratio of the first oxidising base to the second oxidising base is within 0.5 to 1.5, and the mole amount of the first oxidising base is 2.510-3 mole and more per 100 g of the compositions. The inventive subject matter is also dyeing technique implying application of such composition. According to the present invention, it is possible to ensure intensive, aesthetically attractive, low selective and resistant dyeing of keratin fibres with especially visible deep, red shades. ^ EFFECT: present invention allows ensuring intensive dyeing with neutral pH. ^ 16 cl, 2 ex
SUBOXONE and SUBUTEX should be administered with caution in elderly or debilitated patients and those with severe impairment of hepatic, pulmonary, or renal function; myxedema or hypothyroidism, adrenal cortical insufficiency (e.g., Addison's disease); CNS depression or coma; toxic psychoses; prostatic hypertrophy or urethral stricture; acute alcoholism; delirium tremens; or kyphoscoliosis.

The effect of hepatic impairment on the pharmacokinetics of buprenorphine and naloxone is unknown. Since both drugs are extensively metabolized, the plasma levels will be expected to be higher in patients with moderate and severe hepatic impairment. However, it is not known whether both drugs are affected to the same degree. Therefore, dosage should be adjusted and patients should be watched for symptoms of precipitated opioid withdrawal.

Buprenorphine has been shown to increase intracholedochal pressure, as do other opioids, and thus should be administered with caution to patients with dysfunction of the biliary tract.

As with other mu-opioid receptor agonists, the administration of SUBOXONE or SUBUTEX may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
Cyclic glycerophosphates as well as some analogs thereof (CGs) are shown to increase phosphorylation of intracellular proteins in various cells. Such activity is not found with linear .alpha. or .beta. glycerophosphates. The phospharylating activity of the CGs render them useful in the prevention and treatment of various disorders and diseases such as, for example, different kinds of malignancies as well as disorders involving hormone and hormone-like signaling. The CGs are also useful for promotion of target cell differentiation and for detection of abnormal conditions in target cells.