anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicine for treating cardio-cerebral vascular stagnation, which mainly consists of the following raw medicinal materials: monarch medicinal material: dried astragalus root; ministerial medicinal materials: Chinese angelica, Szechuan lovage rhizome, red paeony root, safflower, salvia miltiorrhiza and panax pseudoginseng; adjuvant medicinal materials: leech, lumbricus and Chinese polyphaga; and conductant medicinal materials: cassia twig and the root of bidentate achyranthes. All symptoms cured by using the traditional Chinese medicine are caused by qi deficiency and blood stasis; dried astragalus root is prized in the prescription for tonifying qi so as to flourish qi and promote blood circulation and removing stagnation to dredge collaterals and not hurt the vital essence, and is used as the monarch medicinal material matched with Chinese angelica to invigorate the circulation of blood under the combinational function of all the other medicinal materials, such that the stagnation is removed as well as good blood is not damaged. The Chinses angelica is used for invigorating the circulation of blood, removing stagnation, eliminating blood stasis and stopping bleeding with the help of the Szechuan lovage rhizome, the red paeony root, the safflower, the salvia miltiorrhiza and the panax pseudoginseng to serve as the ministerial medicinal materials together. The lumbricus, the leech and the Chinese polyphaga have the medicinal property of high walking ability and have the enhanced effects on clearing and activating channels and collaterals. The cassia twig is used for warming channels and promoting blood circulation. The root of bidentate achyranthes is used for removing the blood stasis, promoting the blood stasis and ensuring proper downward flow of the blood; therefore, qi and blood go up and down in order under the rising and declining functions alternatively.
A preparation method for a dual-drug-linker of an ADC and a use thereof. Specifically provided are a dual-drug link assembly unit represented by formula III, or a stereoisomer thereof, or an optical isomer thereof. The dual-drug link assembly unit can be linked to a targeting linker to obtain a dual-drug targeting linker-drug conjugate represented by formula I. The specific structure can effectively reduce the aggregation of the dual-drug targeting linker-drug conjugate, which facilitates process amplification, thereby improving the efficiency of the targeting effect on tumor cells, reducing the toxic and side effects on normal cells, and at the same time, effectively overcoming drug resistance and achieving a synergistic anti-tumor effect. Compared with ADC: Ds-8201 which is already on the market, the ADC provided significantly improves the inhibition effect on HER2 positive cell strains N87 and SK-BR-3d. The dual-drug link assembly unit and the dual-drug targeting linker-drug conjugate have broad application prospects in the preparation of anti-tumor drugs for prevention and/or treatment.
This article aims to assist practitioners in understanding dyslexia and other reading difficulties and assessing students' learning needs. We describe the essential components of language and literacy, universal screening, diagnostic assessments, curriculum-based measurement and eligibility determination. We then introduce four diagnostic assessments as examples, including norm-referenced assessments (i.e. the Comprehensive Test of Phonological Processing second edition and the Woodcock-Johnson IV Tests of Achievement) and criterion-referenced assessments (i.e. the Gallistel-Ellis Test of Coding Skills and the Dynamic Indicators of Basic Early Literacy Skills). Finally, We use a makeup case as a concrete example to illustrate how multiple diagnostic assessments are recorded and how the results can be used to inform intervention and eligibility for special education services.
PURPOSE:To provide a remedy for swelling and pain, by using leaf of ARIJIKU- BIWA as an active component. CONSTITUTION:Fresh leaf of fig tree or INUBIWA (Ficus erecta) shown in Fig. I (oblique projection drawing of the obverse face) and Fig. 2 (oblique projection drawing of the reverse face) is used as an active component of a remedy for swelling and pain. It is effective in remedying lumb ago, arthralgia, shoulder discomfort and pain in muscle and swelling, etc. The remedying effect can be attained simply by applying the fresh leaf to the diseased part. Concretely, a leaf dried in the shade is moistened for about 3-4hr and applied to the diseased part. The remedy works within 4-5hr. When the leaf is applied after bath before going to bed, the pain is eliminated in the morning. The pain can be eliminated by repeating the treatment twice or so or 4-5 times in the case of grave patient. The obverse face of the leaf is made to contact with the skin.
A bioartificial liver (30) to provide liver function to patients with liver insufficiency or failure is disclosed. The bioartificial liver is based on a bioreactor of the type having two fluid paths (42, 46) separated by a permeable medium (38). The bioreactor can be of either hollow fiber or flat-bed configuration. In the configuration using hollow fibers (40), the two fluid paths correspond to the cavity (36) surrounding the hollow fibers (the extracapillary space), and to the lumens of the hollow fibers themselves. Both fluid paths have inlet and outlet ports. Communication between the two fluid paths is across the permeable medium - the hollow fiber material. Hepatocytes (34) are inoculated into the hollow fibers in a solution which quickly forms a highly porous gel. The gel subsequently contracts, leaving an open channel within the hollow fiber adjacent to the gel core entrapped hepatocytes. This channel can be perfused with nutrient media for the hepatocytes.
The usual initial dosage of timolol maleate is 10 mg twice a day, whether used alone or added to diuretic therapy. Dosage may be increased or decreased depending on heart rate and blood pressure response. The usual total maintenance dosage is 20 to 40 mg per day. Increases in dosage to a maximum of 60 mg per day divided into two doses may be necessary. There should be an interval of at least 7 days between increases in dosages. 

Timolol maleate tablets may be used with a thiazide diuretic or with other antihypertensive agents. Patients should be observed carefully during initiation of such concomitant therapy.
Reconstitute the lyophilized levothyroxine sodium for injection by aseptically adding 5 mL of 0.9% sodium chloride injection, USP only. Shake vial to ensure complete mixing. The resultant solution will have a final concentration of approximately 20 mcg per mL, 40 mcg per mL and 100 mcg per mL for the 100 mcg, 200 mcg and 500 mcg vials, respectively. Reconstituted drug product is preservative free and is stable for 4 hours. Discard any unused portion. DO NOT ADD LEVOTHYROXINE SODIUM FOR INJECTION TO OTHER IV FLUIDS. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
OBJECTIVE: To examine the expression and function of necroptosis-associated miRNAs in esophageal squamous cell carcinoma.
METHODS: A total of three microarray datasets, i.e., GSE122497, GSE114110, and GSE43732, were selected from the GEO database for differential analysis of necroptosis-related miRNA expression. The differentially expressed miRNAs were screened for target miRNAs using Kaplan-Meier survival analysis in the OncomiR database. The expression of the target miRNAs in the HEEC, KYSE-450, TE-1, and KYSE-410 cell lines was measured via qPCR. The expression of the target miRNAs in esophageal cancer cells was regulated by transfection with Lipofectamine 2000, and cell proliferation, cell migration, cell apoptosis and the cell cycle were detected by CCK-8, Transwell, and flow cytometry.
RESULTS: The tumor tissue and peripheral blood of esophageal squamous cell cancer patients showed differential expression of 7 miRNAs related to necroptosis. Survival analysis revealed that miR-425-5p and miR-16-5p were negatively correlated with patient survival. The esophageal squamous cell carcinoma cell lines exhibited increased expression of miR-425-5p and miR-16-5p, with KYSE-410 exhibiting the most significant increase. Inhibition of miR-425-5p and miR-16-5p expression in the KYSE-410 cell line resulted in increased apoptosis, decreased proliferation, and decreased migration of esophageal cancer cells as well as a significant increase in the S phase and a decrease in the G2/M phase according to the cell cycle assay.
CONCLUSION: The pro-carcinogenic role of miR-425-5p and miR-16-5p has been observed in esophageal squamous cell carcinoma.
PURPOSE:To provide the titled composition containing an oil composed of a vegetable oil, an animal oil and a synthetic oil and a branched-chain fatty acid cholesteryl ester, effective to keep the skin around the anus to a clean state, and prevent the aggravation of hemorrhoids, etc. CONSTITUTION:The objective composition for wiping and cleaning the skin contains a vegetable oil (e.g. magnolia oil, olive oil, etc.), an animal oil (e.g. squalane, lanolin, etc.) and a synthetic oil (e.g. glycerol tri-2-ethylhexanoate, liquid paraffin, etc.) in combination with an ester of formula (R is 1-23C saturated aliphatic hydrocarbon group having at least one alkyl substituent group between the carboxyl-bonded site and the middle of the main chain). The oil may be used singly or as a mixture. The amount of the ester is preferably 20-80wt% based on the whole composition, and the composition is preferably compounded further with 10-80wt% of silicone oil.
Subjects will be American Indian, between the ages of 18-68. Approximately 66% will be female, 33% male, which conforms to the distribution of PTSD in this population. Study group subjects will be PTSD positive. Overt CVD is exclusionary.
A process for the concentration of hepatitis B antigen (HBsAg) from clarified plasma of a human hepatitis donor is described. In this process, the clarified plasma is subjected to ultracentrifugation with isopycnic band formation in a sodium bromide density gradient, the sodium salt of the HBsAg being formed. A fraction is obtained from this which contains the enriched HBsAg. This fraction can be subjected to a zonal ultracentrifugation step, a salt of the HBsAg being formed when using a salt density gradient and a complex of the HBsAg being formed when using a non-salt density gradient. In this way, purified HBsAg can be prepared. The products obtained by the process according to the invention can be employed as a preventive vaccine or for the production of a vaccine against hepatitis B.
The Synergy Disc is a cervical disc prosthesis that can be inserted between C3-C7 in skeletally mature patients after anterior discectomy to provide restoration of motion to the functional spinal unit. The Synergy Disc is designed to restoring kinematics to the cervical spine. The Synergy Disc is intended for use in the cervical spine for reconstruction of the disc following a single level discectomy for intractable radiculopathy and/or myelopathy.
IBD-patients (age at enrollment: 18-80 years) receiving a newly introduced Vedolizumab (VDZ) therapy (n=1.800). A former therapy with other biologics is allowed. More than 30% of these Vedolizumab patients will be biologics-naiv.
Routine physical therapy and exercise program will be applied to all patients for a total of 4 weeks, 5 days a week, 1 hour/day. A total of 20 sessions of treatment will be given to each patient.
Hearing loss (HL) is one of the most common health problems worldwide. Autosomal recessive non-syndromic sensorineural hearing loss (ARNSHL) represents a large portion of congenital hereditary HL. Our study was conducted on 13 patients from 13 unrelated families. The majority of patients presented with congenital severe to profound bilateral sensorineural HL. All patients were subjected to detailed family history and three-generation pedigree analysis to exclude any environmental cause and to ensure an autosomal recessive mode of inheritance. Molecular analysis was performed using the whole exome sequencing (WES) technique for the recruited patients. Three variants in the MYO7A and OTOF genes were reported for the first time in patients with ARNSHL (one nonsense, one frameshift, and one splice variant). Ten previously reported variants were detected in seven genes (GJB2, MYO15A, BSND, OTOF, CDH23, SLC26A4, and TMIE). They varied between missense, nonsense, frameshift, and splice variants. This study expands the molecular spectrum of two types of autosomal recessive deafness (types 2 and 9).
Atrial fibrillation (AF) is a very common cardiovascular disease. Symptoms include dizziness, palpitations, lightheadedness, shortness of breath, fatigue and exercise intolerance. AF is also associated with a high risk of complications like thrombo-embolism and stroke, heart failure, dementia. The presence and severity of these symptoms and complications adversely affect a patient's health related quality of life. Improvement in quality of life (QOL) is an important measure for evaluating response to treatment in AF patients. Depression and anxiety are significant part of the psychosocial burden faced by approximately one-third of AF patients, and are important components that effect QOL in these patients. In this study the investigators will apply the 3RP (Relaxation Response Resiliency Program - developed at the Benson Henry Institute at Massachusetts General Hospital) intervention among AF patients to assess the reduction in their stress, anxiety and depression levels and the reduction in AF symptom burden and severity.
The present invention provides a manufacture method of acetic acid bacteria membrane and the applications. This manufacture method adopts a stage-culture technique which includes two different stages of proliferating the acetic acid bacteria to a mass quantity and synthesizing the cellulose, and uses different culture media. The first stage adopts a fermentation tank culture or a shaking method to culture the acetic acid bacteria to have a quick proliferation. The second stage adopts a stillness culture so as to make the acetic acid bacteria use the components in the culture media to synthesize massive cellulose and cross-link to be an acetic acid bacteria membrane. This manufacture process can shorten the forming time of acetic acid bacteria membrane and substantially lower the production cost. This acetic acid bacteria membrane can be prepared to be a substrate of acetic acid bacteria bio-mask by a heat treatment process. The substrate can be further processed to be an acetic acid bacteria bio-mask which has the merits of tenderness, excellent moisturization, good skin adhesion and bio-degradable environment protection.
Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their distinct and shared neurophysiological mechanisms remain elusive. In this study, we conducted a comparative analysis of the effects of KET and ISO on c-Fos expression across the mouse brain, utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the responses of individual brain regions to each anesthetic. Our findings reveal that KET activates a wide range of brain regions, notably in the cortical and subcortical nuclei involved in sensory, motor, emotional, and reward processing, with the temporal association areas (TEa) as a strong hub, suggesting a top-down mechanism affecting consciousness by primarily targeting higher order cortical networks. In contrast, ISO predominantly influences brain regions in the hypothalamus, impacting neuroendocrine control, autonomic function, and homeostasis, with the locus coeruleus (LC) as a connector hub, indicating a bottom-up mechanism in anesthetic-induced unconsciousness. KET and ISO both activate brain areas involved in sensory processing, memory and cognition, reward and motivation, as well as autonomic and homeostatic control, highlighting their shared effects on various neural pathways. In conclusion, our results highlight the distinct but overlapping effects of KET and ISO, enriching our understanding of the mechanisms underlying general anesthesia.
The present invention provides a micromolecular organic gel for orthotopic injection and a preparation method and application thereof. A technical scheme is as below: a micromolecular organic gel comprises a dicarboxylic acid derivative and polyethylene glycol. The preparation method of the micromolecular organic gel for orthotopic injection is as below: 1) preparing the dicarboxylic acid derivative; 2) taking the above dicarboxylic acid derivative, adding polyethylene glycol (PEG), properly heating under ultrasonic condition, dissolving and standing to obtain a stable clarified solution. The stable clarified solution can be used for orthotopic injection and form stable hydrogel with water. The temperature for heating under ultrasonic condition is 80-90 DEG C, and a water-bath is employed for heating. The prepared micromolecular organic gel for orthotopic injection can be used as a slow-release medicament. The invention has the advantages of small application amount of organic matter, and good stabilization, mechanical property and extremely low toxicity of the formed gel.
Facilitating the dissemination of disease risk information and promoting engagement in healthful behaviors within families may be enhanced by using network-based interventions. Network-based interventions are innovative in that they are tailored to the structure of the social system within which individuals are embedded. Understanding the social and relational factors associated with processes of family risk dissemination, family encouragement, and support is essential to developing network-based intervention tools targeting the family. The first objective of the current project is to ascertain those key social pathways that can be used in a family-centered network-based intervention that promotes disease prevention and health promotion in at-risk families. To this end, efforts will be focused on assessing whether there is a consistent, small set of relational characteristics associated with the dissemination of family risk information and processes of both behavioral and emotional adaptation to disease risk across various disease and cultural contexts. The second objective is to examine the feasibility of using cognitive network approaches to assess social interactions among family members as a means to enhance the implementation of a network-based intervention. A cognitive network is an individual's perception of the relationships among their family (or network) members. Thus, cognitive network approaches can potentially be used to capture an accurate representation of family social structure based on the information provided by a small subset of optimally situated family members. Those key social pathways identified within the first objective of this research will be used to address the second objective. Families affected by diseases and disorders that span the spectrum of genetic penetrance, ranging from highly penetrant, monogenetic disease to less penetrant, common complex conditions, will be recruited for the study. Further, the current effort will seek to engage samples from diverse cultural backgrounds to address our limited knowledge regarding risk communication and adaptation in such families and to facilitate generalization of results. Study participants will be recruited from established cohorts, outreach events, or ongoing studies, both at the NIH and at extramural institutions. Family members will be recruited using a snowball sampling approach and will be asked to complete an in-person, web-based and/or telephone survey/interview. Interviews will have a semi-structured format to allow for slight deviations in prompts and probes to address participant questions. The research addressed in this protocol will lead to the development of an innovative methodology with the potential to improve the design and implementation of family-based interventions that promote disease prevention.
Upper tract urothelial carcinoma (UTUC) is a relatively rare yet aggressive malignancy. While radical nephroureterectomy (RNU) remains the cornerstone treatment, UTUC has high local and metastatic relapse rates, leading to a dismal prognosis. To identify the clinicopathological factors associated with an increased risk of local and metastatic relapse in UTUC, we conducted a retrospective analysis of 133 consecutive UTUC patients who underwent RNU from 1998 to 2018. Patients lost to follow-up or with a history of bladder cancer were excluded from the study. The remaining 87 patients were categorized into two subgroups: those with tumor recurrence/relapse (40 cases) and those without recurrence/relapse (47 cases). Clinical and pathological characteristics were compared across the two groups. Multiple factors are associated with UTUC recurrence/relapse including larger tumor size, histology divergent differentiations/subtypes, high tumor grade, advanced pathologic T stage, positive margin, lymphovascular invasion (LVI), positive lymph node status, and preoperative hydronephrosis. Multivariate Cox regression analysis revealed that squamous differentiation predicted recurrence/relapse (p = 0.012), independent of tumor stage. Moreover, compared to the conventional histology type, UTUC with squamous differentiation had a significantly higher relapse rate (p = 0.0001) and poorer survival (p = 0.0039). This observation was further validated in invasive high-grade UTUC cases. Our findings suggest that many pathological factors contribute to UTUC recurrence/relapse, particularly, squamous differentiation may serve as an independent risk predictor for relapse and a potent prognosticator for adverse cancer-specific survival in UTUC patients. Recognizing and thoroughly assessing the pathological factors is essential for better oncologic management of UTUC.
PURPOSE:A cosmetic, containing a water-insoluble water absorbing polymer consisting of fibroin, a crosslinking monomer, an anionic monomer or further a nonionic monomer as an emulsifying agent, having improved emulsion stability, etc. without irritant action on the skin, and capable of giving improved properties to hair. CONSTITUTION:A cosmetic containing 0.05-5.0wt% water-insoluble water absorbing polymer consisting of 1-40wt% fibroin (regenerated), 0.1-5wt% crosslinking monomer, e.g. ethylene glycol dimethacrylate, 60-95wt% anionic monomer, e.g. acrylic acid, and 0-20wt% nonionic monomer, e.g. an acrylic ester, as an emulsifying agent. The cosmetic has improved emulsion stability, viscosity stability, humectant property in use, water resistance, touch, make-up durability, etc. without irritant action on the skin and is capable of giving softness, smoothness and gloss to the hair. The water absorption of the polymer is at least 60ml/g, and the cosmetic may further contain ethanol.