anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
S-Carboxymethylcysteine <FORM:1071807/C2/1> is prepared by alkylating cysteine with an alkali metal monochloroacetate, in the presence of a proton acceptor, preferably NaOH the reaction is carried out in aqueous solution at about 5 DEG C., under inert gas (nitrogen) and when complete the product is precipitated by acidifying the reaction mixture and recrystallized from alkaline solution by addition of acid. The product is afterwards converted to its sodium salt in aqueous solution, for use in a pharmaceutical composition (see Divisions A5-A6).ALSO:Pharmaceutical compositions for topical application comprise a water-in-oil emulsion of a solution of a non-toxic, water-soluble salt of S-carboxymethyl cysteine in an aqueous phase uniformly dispersed throughout a non-toxic topically applicable unguent lipid carrier as the non-aqueous phase. The composition preferably includes one or more surface active agents, such as polyoxyethylene sorbitan monooleate, alkali metal lauryl sulphonates, and triethanolamine stearate. The preferred soluble salts are those of alkali metals or ammonium organic bases such as mono-or tri-ethanolamine, or basic aminoacids such as lysine or arginine. The lipid medium may contain one or more of glyceryl mono-stearate or-palmitate, lanolin or hydrogenated lanolin, perhydrosqualene, polyethylene glycols, propylene glycol stearate, hydrogenated oils and mixed esters of glycerol and polyoxyethylene glycol obtained by subjecting oils such as almond p oil to alcoholysis in the presence of polyoxyethylene glycols, cholesterol or its palmitate, sorbital, preservatives, (benzalkonium chloride or sorbic acid), and suitable coloring agents. Other active ingredients may be present, such as thyroxin and vitamin A. The compositions are useful for treating fragility of human nails.
The Translational Health in Nutrition and Kinesiology (THINK) program will have education and fitness sessions lasting two hours, five times a week for a total of 10 weeks. Sessions will include theory, clinical laboratory activities, and physically active games to facilitate a fun environment to enhance physical and health-related fitness, improve nutrition and exercise knowledge and behaviors, and exercise enjoyment and self-confidence.
Healthy participants will receive single oral dose of Aticaprant (Dose 1) (Treatment A) in Treatment Period 1, followed by Moxifloxacin (Dose 2) (Treatment D) in Treatment Period 2, followed by Aticaprant (Dose 3) (Treatment B) in Treatment Period 3 and then placebo (Treatment C) in Treatment Period 4, on Day 1 of each treatment period. There will be a wash-out period up to 7-15 days between each treatment period.
The aim of the study is to examine whether the pilot intervention can reduce mistrust and improve coping responses to discrimination among HIV positive Black men who have sex with men (MSM). We will conduct a small randomized pilot trial to test the feasibility of evaluation methods. All participants will attend a baseline, a first follow-up visit, and a final follow-up visit (each 3 months apart) at which they will take computer assessments. Participants who are assigned to the intervention will attend 9 weekly intervention sessions after baseline and before the first follow-up. Using a wait-list control design, control group participants from the first two cohorts will be offered the intervention after they complete the final follow-up visit. Control group participants from the third cohort will be offered the intervention after they complete the first final-up visit and before they complete their final follow-up due to timing and budgetary restraints. We will hold three consecutive groups for our small randomized control trial. This means that we will be recruiting continuously; once we finish recruiting for the first group, we will start recruiting for the second group, and so on. Each group has about 12 or 13 intervention and 7-11 control participants.
Power and control systems for a drug delivery device allow for the activation, control of, and communication with the drug delivery device. The power and control system allows for a delay between device activation, and optionally needle insertion, and commencing drug delivery. The delay may be for a predetermined time. In addition, the power and control system may communicate with one or more external sensors and devices. The inputs from the sensors and devices may automatically, or on demand, adjust the delivery parameters of the device. The power and control systems may control a drive system that delivers a fluid at a variable rate or profile, allowing for the delivery to be tailored to maximize the effectiveness of the treatment.
Patients receive veliparib by mouth (PO) twice a day (BID) on days 1-7 and temozolomide PO every day (QD) on days 1-5. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
TAK-925, Intravenous single administration. Dose level will be determined by targeted plasma level of TAK-925 (Dose level 5). Healthy adults will be enrolled in non-blinded manner.
PURPOSE: A pharmaceutical composition and a health functional food containing Curcuma longa L. and Hovenia dulcis Thunb. extract for preventing and treating obesity are provided to lower body weight, fat weight, ATL in blood, HDL cholesterol, and fatty liver. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity contains extracts of 0.1-80 parts by weight of Curcuma longa L., 0.1-40 parts by weight of Hovenia dulcis Thunb., and 0.1-40 parts by weight of Massa Medicata Fermentata as an active ingredient. The extract is prepared using water, low carbon number alcohol of C1-C4, or a mixture thereof. The dose of the composition is 0.01-1000 mg/kg(body weight). A health functional food for preventing and treating obesity contains the extracts as an active ingredient.
Once a week injection of Semaglutide (a GLP-1 receptor agonist) in addition to standard of care insulin for the first six months in 2/3 of patients (76 patients). Semaglutide is a clear, colorless solution that contains 2 mg of semaglutide in a 1.5 mL (1.34 mg/mL) pre-filled, disposable, single-patient-use pen injector. Semaglutide will be started at the 0.25 mg dose for the first two weeks, then increased to 0.5 mg at week 2, and then yet again increased to 1.0 mg at week 4.
The invention provides a memory card device with a data uploading function and a data uploading method applied to the memory card device. The memory card device comprises a processing chip and a memory module. The processing chip is used for switching between a data access mode and a data uploading mode. The memory module is used for storing a first data set generated by a medical device at a first time and a second data set generated by the medical device at a second time. Under the data access mode, the processing chip establishes a first storage list according to the first data set and updates the first storage list into a second storage list according to the second data set. When the processing chip judges that the second data set conforms to a preset condition, the processing chip enters the data uploading mode and uploads the corresponding data of the second data set to a back-end host. The invention can automatically upload the data generated by the medical device to the remote device, so that the remote user can know the condition of the patient in real time.
Eltrombopag will be administered orally once daily for 24 weeks (6 months) and the dose will be adjusted according to race, age and weight. Patients who achieve at least partial remission may continue treatment for up to one year.
Imaging cohort All study participants will be allocated to this arm (single-arm study). Study participants will undergo 68Ga-N188 PET/CT scan.
A device for insertion into a body cavity (15) e.g. the rumen of an animal for example a cattle beast is in the form of a resilient helical coil (1) with bio degradable portions (2,3). The device is deformable to have a smaller dimension to enable insertion through a body passage (17) into the animal cavity. The device carries a drug eg. progesterone and is retained in the body cavity (15) for a time during which the drug is active. After time has passed the device is broken up by biodegrading activity into pieces small enough to be discharged naturally by the animal. An applicator is provided.
The invention discloses a traditional Chinese medicine preparation for treating psoriasis and neurodermatitis. The traditional Chinese medicine preparation comprises the raw material medicine in parts by weight: rhizoma smilacis glabrae, cortex dictamni, subprostrate sophora, paris polyphylla Sm, airpotato yam rhizome, selfheal, radix paeoniae alba, cocklebur fruit, crude rehmannia, tribulus ferrertris and radix sophorae flavescentis. The preparation comprises pills, powder, tablets, oral liquid preparation and capsule preparation prepared by the traditional preparation process or modern preparation process. The medicine has the functions of clearing heat, cooling blood, invigorating the circulation of blood, eliminating stagnate, stopping the wind and asmolysis, killing bug and stopping urticant. The invention improves the immunity function of an engine body via oral taking and has favorable effect for treating paoriasis caused by various pathogenesis. The clinic application proves that the invention has the advantages of rapid action, obvious curative effect, good tolerance, low cost and no toxic and side effect.
Patients will be administered an Introduction Form and Spielberg State-Trait Anxiety Scale before surgery. The Vital Signs Record Form will be filled out on the patient's operating table. Then, therapeutic touch will be applied for 15-20 minutes during the surgery. After the procedure, the Vital Signs Record Form, Spielberg State Anxiety Scale and Perianesthesia Comfort Scale (PCS) will be administered.
OBJECTIVE: This study aimed to analyse the characteristics of biochemical recurrence after radical prostatectomy via bi-parametric magnetic resonance imaging.
METHODS: A total of 200 patients with radical prostatectomy admitted to our hospital from January 2016 to January 2021 were retrospectively enrolled as observation objects. According to whether there was biochemical recurrence after surgery, the patients were divided into the abnormal group (n = 62) and normal group (n = 138). Clinical data, encapsulation infiltration, seminal vesicle infiltration and prostate imaging report and data system (PI-RADS) were collected and compared between the two groups. Propensity score matching (PSM) was used to balance the baseline data of the two groups. Student's t-test and Chi-square test were used to analyse the data.
RESULTS: PSM was performed in a 1:1 ratio, and a total of 72 patients were included in the abnormal and normal groups. The baseline data of the patients in each group were not statistically significant. The incidence of extraperitoneal invasion and seminal vesicle invasion was higher in the abnormal group than in the normal group, and we observed a significant difference in PI-RADS scores between the two groups (p < 0.05). Extracapsular invasion, seminal vesicle invasion, PI-RADS score and biochemical recurrence were significantly correlated (p < 0.05). The PI-RADS score has a high value for predicting biochemical recurrence, with an area under the curve value of 0.824, sensitivity of 0.667, specificity of 0.861 and Youden index of 0.528.
CONCLUSIONS: Bi-parametric magnetic resonance imaging has a high predictive value in biochemical recurrence after radical prostatectomy, which can provide reference for early intervention measures.
Infectious urolithiasis is a type of urolithiasis, that is caused by infections of the urinary tract by bacteria producing urease such as Proteus mirabilis. Lactobacillus spp. have an antagonistic effect against many pathogens by secreting molecules, including organic acids. The aim of the study was to determine the impact of Lactobacillus strains isolated from human urine on crystallization of urine components caused by P. mirabilis by measuring bacterial viability (CFU/mL), pH, ammonia release, concentration of crystallized salts and by observing crystals by phase contrast microscopy. Moreover, the effect of lactic acid on the activity of urease was examined by the kinetic method and in silico study. In the presence of selected Lactobacillus strains, the crystallization process was inhibited. The results indicate that one of the mechanisms of this action was the antibacterial effect of Lactobacillus, especially in the presence of L. gasseri, where ten times less P. mirabilis bacteria was observed, compared to the control. It was also demonstrated that lactic acid inhibited urease activity by a competitive mechanism and had a higher binding affinity to the enzyme than urea. These results demonstrate that Lactobacillus and lactic acid have a great impact on the urinary stones development, which in the future may help to support the treatment of this health problem.
Health organizations recommend fiber-rich and whole-grain foods for healthy diets due to their physiological beneficial effects on human health. But, little information is available between these 2 food categories, i.e. fiber added to foods versus fiber naturally present in foods. The present study investigated the effect of enriching white wheat flour with wheat bran at 2 levels (15 and 30%) to produce 15% fiber-rich bread (15FRB) and 30% fiber-rich bread (30FRB) and compared them with white bread (WB) and whole-grain bread (WGB) in terms of bread quality, palatability, satiety, and glycemic response. Ten healthy subjects were studied on 4 separate days with each subject testing all 4 types of bread. On each test day subjects came to the test center after an overnight fast. After 2 fasting finger-prick blood samples 5 minutes apart, they ate a portion of one of the breads containing 50g available carbohydrate and had further blood samples at 15, 30, 45, 60,90 and 120 min after starting to eat. After each blood sample also rated their feelings of satiety on a 7-point scale from extremely hungry to extremely full.
This study aimed to compare the dietary factors related to sarcopenia and obesity status in 5458 elderly individuals (2391 men and 3076 women) aged ≥65 years from the Korean National Health and Nutrition Examination Survey (2016-2019). Participants were categorized into normal, sarcopenia, obesity, and sarcopenic obesity groups. Sarcopenic obesity showed a higher prevalence of diabetes and lower HDL cholesterol levels compared to obesity. Sarcopenic obesity exhibited a lower total KHEI score and lower adequacy, including meat/fish/eggs/beans, than normal or obesity. In women, sarcopenic obesity scored lower than obesity on the total KHEI, adequacy for most foods, and balance of energy intake, and lower than sarcopenia on the adequacy of breakfast and milk/milk products. Sarcopenic obesity showed no significant difference in energy intake compared to sarcopenia, and less physical activity compared to sarcopenia and obesity, with a BMI/waist circumference comparable to that of obesity. Low total KHEI scores and scores for meat/fish/eggs/beans were most closely associated with sarcopenia in men and with sarcopenic obesity in women. In conclusion, low dietary quality and inadequate protein-rich foods are possibly associated with the prevalence of sarcopenic obesity in elderly Koreans, especially in women. Adequate energy intake and dietary diversity may be effective in managing sarcopenic obesity.
Participants will undergo a diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption. Following the 12-week blinded trial period, these participants will be unblinded and offered Endoscopic per-oral pyloromyotomy (POP) if they remain symptomatic.
PURPOSE:To provide the title bandage of excellent performance, free from feeling of physical disorder, consisting of a laminate made up of a filmy mucous membrane-applicable base comprising a vinyl acetate resin, hydrophilic polymer and water insoluble plasticizer and a filmy base material comprising a vinyl acetate resin and water-insoluble plasticizer. CONSTITUTION:The objective bandage consisting of a laminate made up of (A) a filmy mucous membrane-applicable base comprising (1) a vinyl acetate resin, (2) a hydrophilic polymer (e.g. sodium alginate) and (3) a water-insoluble plasticizer (e.g. orange oil, sorbitan monolaurate) and (B) a filmy base material comprising (a) a vinyl acetate resin and (b) a water-insoluble plasticizer. This bandage gives excellent applicability on the oral mucous membrane, being flexible and high in resistance o water. Because of being in a sheet-like form, the present bandage is free from feeling of physical disorder, thus adequately protecting the applied area of the mucous membrane. It is effective in therapy and can also be used as a base for percutaneous absorption of medicinal ingredients.
Panobinostat was administered orally, once-a-day, on Monday-Wednesday-Friday (MWF), every other week, as part of a 28-day treatment cycle. Group Y is a sub-arm, based on disease indication.
BACKGROUND: This study describes an outbreak caused by multispecies carbapenemase-producing Enterobacterales (CPE) occurring in a pediatric ward at an academic medical center in Tokyo.
METHODS: The index case involved a 1-year-old boy with Klebsiella variicola (CPE) detected in anal swabs in June 2016. The second case was Klebsiella quasipneumoniae (CPE) occurred in March 2017 followed by further spread, leading to the declaration of an outbreak in April 2017. Extensive environmental and patient microbiological sampling was performed. The relatedness of the isolates was determined using draft-whole-genome sequencing.
RESULTS: CPE surveillance cultures of patients and environments were positive in 19 patients and 9 sinks in the ward. The sinks in hospital rooms uninhabited by CPE patients exhibited no positive CPE-positive specimen during the outbreak. All CPE strains analyzed using draft-whole-genome sequencing harbored blaIMP-1, except for one harboring blaIMP-11; these strains harbored identical blaIMP-1-carrying IncM1 plasmids. CPE was detected even after sink replacement; infection-control measures focused on sinks were implemented and the CPE outbreak ended after 7 months.
CONCLUSIONS: Multiple bacterial species can become CPE via blaIMP-1-carrying IncM1 plasmids of the same origin and spread through sinks in a hospital ward. Thorough infection-control measures implemented as a bundle might be crucial.
Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest and a gene encoding a receptor, the gene of interest operably linked to a genetic element capable of being induced by the receptor when bound to a ligand, and the receptor not naturally present in the species of the cell. The cells also comprise a caged ligand of the receptor. Additionally provided are methods of inducing a gene of interest in the above cells. Also provided are methods of repressing a gene of interest in a cell using caged ligands of receptors. Methods are additionally provided for inducing elimination of a target sequence in a cell of a species, using a caged ligand and a recombinase.
Neonate randomized to this group will be managed as per the standard protocol in the neonatal ward. The evaluation of respiratory distress will be done using Downe's score at hourly intervals till 24 hrs, followed by 2 hourly intervals till 72 hrs and finally 4 hourly intervals till resolution of clinical distress.
PURPOSE:The titled composition for raising absorption of a remedy for astham in blood and for improving durability of action time, obtained by blending the remedy for asthma with a phospholipid, collagen, cyclodextrin, etc. CONSTITUTION:A composition for remedying bronchial asthma comprising a remedy for asthma and at least one selected from a phospholipid (e.g., phosphatidyl choline), collagen and cyclodextrin. Collagen is albuminoid mainly comprising skin, bone, tendon, gristle or bonded tissue of young bovine, etc., and cyclodextrin is a non-reducing sugar wherein D-glucose is circularly bonded. Addition of these compounds raises absorption of the remedy for asthma, especially absorption from exodermis, has prolonging effect on durability of medicinal effects, reduces a does and lessens times of administration. The amount of these compounds blended is >=5pts.wt. calculated as the phospholipid alone or total amounts based on 100pts.wt. remedy for asthma.
BACKGROUND AND OBJECTIVES: Persistent neuropathic pain after brachial plexus avulsion (BPA) is common and generally nonresponsive to medical management. Dorsal root entry zone (DREZ) lesioning is the last resort for pain management in patients with BPA. This study aims to investigate and compare the outcomes and complications of DREZ procedures.
METHODS: A systematic literature search was conducted to identify all related studies. Comparisons were based on the number of patients with preoperative pain vs postoperative pain, with the effect size calculated using the risk ratio. Mean visual analog scale (VAS) scores were extracted and analyzed between interventions. A meta-regression analysis was performed to identify risk factors for final outcomes. The rates of complications were also assessed and analyzed between interventions.
RESULTS: A total of 30 studies with 917 patients (90.0% male and 10.0% female, mean age: 42.9 ± 16.6) were included in this systematic review. Of the 917 patients who underwent surgery, 655 (71.4%) patients had significant pain reduction at the last follow-up ( P < .05). The weighted mean preoperative VAS score was 8.3 ± 1.3, compared with postoperative VAS scores (1.9 ± 2.2); a significant improvement was observed ( P < .05). The subgroup analysis showed that microsurgical DREZotomy (MDT) is associated with better outcomes in terms of VAS score improvements compared with radiofrequency (RF)-assisted DREZ lesioning ( P < .05). Meta-analysis showed that the relative risk of motor deficits was significantly lower in the MDT group, compared with the RF-assisted group ( P < .05). Meta-regression showed that older age is correlated with an elevated risk of postoperative motor deficits compared with the incidence of sensory loss.
CONCLUSION: DREZ lesioning is effective for intractable pain alleviation after BPA. Compared with RF-assisted DREZ lesioning, MDT is associated with better VAS score improvements and a lower rate of postoperative motor weakness.
The present invention provides macromolecules comprising at least one thioether cross-link. A thioether cross-link comprising a single thioether bond between two residues of a macromolecule. The macromolecules of the invention can display enhanced stability, pharmaceutical properties and functional properties. In particular, the invention provides an isolated antibodies comprising at least one thioether cross-link that specifically bind to particular antigens. The present invention also provides a composition comprising a macromolecule substantially free of a denaturing reagent, wherein the macromolecule comprises at least one thioether cross-link. In addition, the present invention provides a method for producing the macromolecules and compositions of the invention.