anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Each year about 18000 persons in Sweden suffer from a hip fracture. These people are often among the oldest and have many complicating diseases. The one-year mortality after hip fracture is 20%. Due to the complexity including many comorbidities in these patients, it is of great value that the care of these patients is optimal.

Today, most of the patients with suspected hip fracture in the catchment area of Sahlgrenska University hospital, Gothenburg, are transported directly to the radiology unit. Thereafter, the patient waits in the emergency room (ER) for an othopedic examination before being admitted to primarily a geriatric medicine ward where they wait for the operation. The average waiting time in the ER is today around four hours. The current scientific evidence for fast-tracking hipfracture patients is limited. The aim of our randomized controlled trial is to determine the effect of fast-tracking hip fracture patients at geraitric medicine wards compared to standard care regarding complication rate (primary endpoint), lenght of hospital stay and time to operation (secondary outcomes).
Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.
PROBLEM TO BE SOLVED: To provide a blood sampling apparatus containing a molded granular additive by specifying a mesh size of additive particle consisting of a low-soluble component and a high-soluble component dissolving and dispersing the low- soluble component in a blood sample by the high-soluble component to expose and increase a surface area of the low-soluble component. SOLUTION: A blood sampling tube 10 has an aperture terminal 16, an aperture terminal 18 and a stopper 14. The stopper 14 contains a bent bottom site or a skirt 15 that enlarges against a sidewall 12 of the tube and projects. A blood sample is transferred to the tube 10 containing a granular additive 20, wherein the granular additive 20 is dissolved rapidly in the blood by bringing the blood sample into contact with the granular additive 20 efficiently. Thereby, glycolysis and blood coagulation can be inhibited for a specified period. Herein, the granular additive 20 consists of a low-soluble component and a high-soluble component, and the additive has a mesh size of about 20-120. The low-soluble component is dissolved in the blood sample by the high-soluble component, to expose and increase the surface area of the low-soluble component.
OBJECTIVES: X-linked hypophosphatemia (XLH) is characterized by increased concentrations of circulating fibroblast growth factor 23 (FGF-23) resulting in phosphate wasting, hypophosphatemia, atypical growth plate and bone matrix mineralization. Epidemiologic studies suggest a relationship between FGF-23, obesity, and metabolic dysfunction. The prevalence of overweight and obesity is high in children with XLH. We aimed to evaluate the prevalence of obesity and metabolic complications in adults with XLH.
METHODS: We conducted a prospective cohort study in adult XLH patients from a single tertiary referral center. The proportion of patients with a BMI >25 kg/m2 was the main outcome measure. Body fat mass percentage (FM%) and adipose tissue surfaces were secondary outcome measures. Glucose homeostasis (plasma glucose and insulin concentrations after fasting and 2 hours after an oral glucose tolerance test) was explored in a subgroup of patients and compared with age-, sex-, and BMI-matched healthy controls.
RESULTS: Among 113 evaluated patients, 85 (75%) were female and 110 (97%) carried a PHEX mutation. Sixty-three (56%) patients were overweight or obese, with a median BMI of 25.3 [IQR, 22.7; 29.2] kg/m2. BMI was correlated with FM%, abdominal and thigh subcutaneous and intra-abdominal adipose tissue surfaces. The prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetes was not different between XLH patients and matched controls.
CONCLUSION: The prevalence of overweight and obesity is high among XLH patients and is associated with excess fat mass. However, the prevalence of glucose homeostasis abnormalities is not increased in patients compared to healthy controls, suggesting that metabolically healthy overweight or obesity predominates.
At the University of Bristol, we established a novel dissection course to complement our anatomy degree. Students enrolled in this undergraduate course are trained as comparative anatomists, with equal time given to both human and veterinary anatomy. Historically, students opted to dissect either human or veterinary donors as part of the course. To fully reflect the comparative nature of the degree, the dissection course was redesigned so students could dissect both human and veterinary specimens as part of the same course. This facilitated a wide-ranging experience of anatomy, encouraging detailed knowledge of a multitude of species and allowing for multifaceted anatomy graduates to be ready for employment in a wide and competitive job market. Across three iterations of the amended version of the course, median marks ranged from 58.7% to 62.0%, with between 22 and 39 students enrolled. In comparison to the course prior to the introduction of the change, median marks ranged from 59.8% to 62.8%, with between 16 and 24 students enrolled. There was no significant difference between marks before or after the introduction of the concurrently comparative aspect. This paper describes the course, with learning materials and assessments considered, along with some reflection on its value. The course offers benefits to students by widening their perspective on anatomical knowledge and making them more equipped for the job market. It also broadens their understanding of form-function relationships. However, student feedback implied that having the choice between human or veterinary dissection was preferable, and this may outweigh the perceived benefits of the course.
Intravenous L-citrulline (Turnobi) administration will safely restore the homeostasis of nitric oxide synthase by increasing both plasma citrulline and arginine levels. Investigators also reason that restoration of citrulline/arginine balance through citrulline administration will safely re-establish homeostasis of NOS, lower oxidative stress, and reduce inflammation, thereby delaying and potentially preventing the need for invasive mechanical ventilation in participants hospitalized with COVID-19 infection (SARS-CoV-2). The body lives in a delicate balance of homeostasis. The urea/NO cycle plays a critical role in maintaining redox homeostasis and as such, also plays a role in regulating inflammation. The biochemical relationships are complex and depend on inter-organ transfer, membrane transport, and intracellular compartmentation. However, data above demonstrate that citrulline, arginine, and NO are critical in maintaining this homeostasis through their regulation of NOS. Inflammation, especially from infection, results in decreased activity of CPS1 and increased activity of arginase, which decreases levels of both citrulline and arginine. These decreased levels result in dysregulated and uncoupled NOS, which drives both overexuberant NO production and formation of ROS. Both the NO production and ROS further exacerbate the inflammatory cascade, resulting in other organ dysfunctions, including acute lung injury. Both inflammation and oxidative stress have been shown to be driving forces for the development of ALI and regulated NOS function is vital to reducing both. Both plasma citrulline and arginine are deficient in sepsis and levels are inversely associated with development of ALI. Furthermore, citrulline replacement safely increases plasma levels of both citrulline and arginine in healthy volunteers, BMT patients, adults with sepsis, children with sickle cell disease, and children after congenital heart surgery. It seems highly likely that citrulline therapy in the setting of COVID-19 (SARS-CoV2) induced acute hypoxemic respiratory illness will safely increase citrulline and arginine levels and help re-establish NOS homeostasis, resulting in NO production in compartments that are more homeostatically appropriate so as to reduce pulmonary vascular resistance and enhance coupling of NOS to minimize superoxide production thus reducing free radical mediated ALI.
The present invention discloses composition(s) for increasing the levels of tyrosine hydroxylase in the mammalian brain of human subjects and thus increasing the levels of brain catecholamines, in treating neurological related disorders. The composition(s) comprise(s) a biological extract obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. In an embodiment, the extract is obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. The extract is water-soluble. In another embodiment, the extract further comprises one or more organic compounds. The one or more organic compounds are selected from the group consisting of but not limited to sugars, phenolic compounds, flavonols, stilbenoids, dihydroflavonols, anthocyanins, shikimic acid, soluble fibres and peptides.
The invention provides traditional Chinese medicine medicinal liquor for treating rheumatism. The medicinal liquor is prepared from the following traditional Chinese medicine raw materials: willow branches, golden cypress, rhizoma atractylodis, honeysuckle stems, loofah sponge, caulis sinomenii, radix stephaniae tetrandrae, polygonum cuspidatum, caulis spatholobi, kadsura pepper stems, Chinese starjasmine stems, large-leaved gentian, lycopodium clavatum, liquidambar formosana hance, berba aristolochiae mollissimae, polygonum multiflorum, bighead atractylodes rhizome, semen coicis, hematoxylon and euphorbia pekinensis. The traditional Chinese medicine medicinal liquor for treating rheumatism, which is provided by the invention, based on the therapeutic principle of traditional medicine to bone diseases, follows the theory of traditional Chinese medicine to comprehensively treat rheumatism with reference to modern pharmacological research. The medicinal liquor provided by the invention is suitable for treating various rheumatisms and free from toxic and side effects. The selected traditional Chinese medicinal materials have the effects of promoting blood circulation to remove blood stasis, curing wounds and relieving pains, stopping bleeding and promoting granulation, activating stagnation and eliminating swelling, dissipating stagnation and promoting the circulation of qi, inducing astringency and calming, nourishing the blood and tranquilizing and removing stasis and relieving pains. The medicinal liquor is unique in formula and preparation method and reasonable in formula, and the treatment time is shortened, so that the pains of patients are fundamentally eradicated.
Microvascular function was assessed using caIMR, and 460 coronary arteries were analyzed. CMD was identified with caIMR\>25U, in line with prior research.
<P>PROBLEM TO BE SOLVED: To provide a system which diagnoses a medical condition of a respondent from answers of the respondent to one set of questions.  <P>SOLUTION: In one execution form, the invention is a diagnosis system 100, which contains a first overlay 20 equipped with one or more questions for diagnosis, a due form 3 equipped with one or more answers possible for each diagnosis question and a first overlay 20 equipped with one or more windows 26 and one or more diagnosis columns 27. When the overlay is positioned on the due form 3, answers to the diagnosis question indicating a user having a first medical condition come visible through a window of the first overlay. The due form 3 and the first overlay 20 are provided. The due form 3 and one or more diagnosis columns contain a standard for diagnosing the user having a first medical condition from the user's option on the due form capable of visually seeing through the first overlay window. In another execution form, the invention is the diagnosis system constituted from computer judgement and the diagnosis system.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
OBJECTIVE: We aimed to explore the characteristics of OYST, particularly for persistent and recurrent OYST, in order to explore potential treatment options and thereby improve patient outcomes.
METHODS: We retrospectively reviewed the clinical records of all patients with OYST at Fudan university Shanghai Cancer Center from December 3, 2005 to November 27, 2020. Furthermore, and performed whole-exome sequencing on 17 paired OYST (including 8 paired persistent and recurrent OYST) tumor and blood samples to elucidate the aberrant molecular features.
RESULTS: Totally, 87 OYST patients were included between 2007/03/13 and 2020/11/17. With a median follow-up of 73 [3-189] months, 22 patients relapsed or disease persisted. Overall, 17 patients died with a median overall survival of 21 [3-54] months. Univariate and multivariate analysis revealed tumor histology and residual lesions were independently associated with event free survival and overall survival, cycles to AFP normalization were another independent risk factor for overall survival. For the 8 persistent and recurrent OYST: cancer driver genes including ANKRD36, ANKRD62, DNAH8, MUC5B, NUP205, RYR2, STARD9, MUC16, TTN, ARID1A and PIK3CA were frequently mutated; cell cycle, ABC transporters, HR, NHEJ and AMPK signal pathway demonstrated as the most significantly enriched pathways; TMB, DNA MMR gene mutation and MSI were significantly higher. Mutation signature 11, 19 and 30 were the dominant contributors in persistent and recurrent OYST mutation.
CONCLUSION: Persistent and recurrent OYST associated with poor prognosis, and probably susceptible to immune checkpoint blockade therapy. Molecular characteristics contributed to predict the persistence and recurrence of OYST.
Q-Griffithsin (Q-GRFT) nasal spray (7.5mg/mL). Two metered doses of 100μL into each nostril, total of 3mg Q-GRFT per administration, administered once daily for 14 consecutive days.
The intervention group will immediately receive the Ola Mau i ka Hula intervention after randomization for 12 months. The intervention program is 8 months with a 4 month self-monitoring period.
Participants randomized into chemotherapy arm can receive up to 4 cycles of pemetrexed + cisplatin (pemetrexed 500 mg/m\^2 + cisplatin 75mg/m\^2, IV infusion, every 3 weeks) as the initial treatment. Participants whose disease has not progressed after 4 cycles of first-line platinum-based doublet chemotherapy may receive pemetrexed maintenance monotherapy until a treatment discontinuation criterion is met.
PURPOSE: To provide a water-based cosmetic or dermal compsn. or a vehicle for this compsn. without using an oil or fat or an emulsifier which gives uncomfortable touch more or less to a user so that even after the water is vaporized, the compsn. does not give a tacky or dry touch to the user. CONSTITUTION: Expanded hollow microspheres comprising a thermoplastic material are added to a water-based gel to obtain such a cosmetic compsn. or a vehicle of the cosmetic compsn. as shows exceptional characteristics with creamy touch and mildness when it is used although it does not contain an oil or fat. For example, the compsn. can be used to prepare a makeup foundation compsn., face or body care products, sun-gel including a face mask type one, eye shadows and skin cleaning products.
The biopsy needed is inserted to the prostate through the perineal skin, with the assistance of an access system device known as PrecisionPoint. It utilises a single access needle cannula mounted directly on to the ultrasound probe, which acts as an access point traversing through the perineal skin. 4 - 5 cores are obtained from the anterior, mid and posterior zone of each side of the prostate.
Patients participate in three 15-minute CE sessions, comprising empathic attention with an interventionist who allows patients to direct the flow of conversation and provides supportive comments according to standardized procedures. Patients also receive CDs with recorded information related to coping with colorectal cancer similar in length to the suggested practice time in Arm I.
The disclosed systems and methods manage multiple notifications between medical devices. A method includes obtaining information corresponding to a clinician and determining whether the information meets coordination criteria. The method includes detecting first and second notifications generated by respective medical devices based on a determination that a clinician is associated with the first and second medical devices. The method includes identifying alert information based on detecting the respective notifications, the alert information including medical information of a patient receiving medical treatment from the first and second medical devices. The method includes determining notification priorities between respective notifications based on the identified information. The method includes adjusting at least one human-perceptible presentation of the respective notification based on the determined notification priority, and presenting the adjusted human-perceptible presentation of the respective notification to the user via one of the first medical device or the second medical device.
Participants: Sixty 18-75 years-old patients with acquired brain injury, will be randomly assigned to 30 sessions of competitive versus non-competitive cognitive attentional training (see inclusion-exclusion criteria). Material and Methods: Randomized clinical trial comparing two different attentional training strategies. Attentional measures, usability data and caregiver/family perception of change, will be compared after completing both conditions. Competitive training will include a new computer based training program that involve using attentional skills under different competitive scenarios. Attentional exercises were designed according to the instructions of two experts neuropsychologists and included game-based situations simulating different olympic disciplines.Neuropsychological protocol: An assessment before the beginning of the intervention and pos-treatment will be done by a trained blinded neuropsychologist using measures of selective, sustained, divided and alternating attention (see primary outcome measures). Usability and Motivation: It is well-known that game-based cognitive exercises can increase motivation to treatment which in turn can increase learning strategies and improve outcomes after rehabilitation processes. Competitive tasks can also improve the effort and interest of the players and the intensity of the task through increasing motivation to win, get a reward and beat the others. Since motivation was an important element of our research, we assessed this capacity at the end of the treatment with the Intrinsic Motivation Scale. Also, the revised Competitiveness Index was used to measure the subject's preference for competitive situations. Finally, usability was considered a secondary outcome of our study since most of the games employed here were designed to be played in a new virtual reality system which was build to facilitate competitive strategies among 2-4 players (see secondary outcomes). Sample Size Calculation: There was any previous study that used the design proposed in this investigation. Considering a reduction bigger of 20% on the Hit-Reaction Time of the CPT-II scores in the active group intervention, sample size in both groups of 27 participants and standard-deviation in the magnitude of half of the medium score in each group (moderate variability), the study will be able to detect a moderate effect size (ES = 0,4). Calculating a sample loss of 10% each group, we define a sample size per group of 30 individuals. Statistical methods Statistical analyses will be performed with Statistical Package for the Social Sciences (SPSS) 12.0. The univariate analyses will be performed with the t student test / Mann-Whitney to continuous variables or Chi-Square test (X²) / Fischer test to categorical variables. The effective of the intervention over time will be assess through analyses of mixed models (repeated measures ANOVA).
PURPOSE:The titled remedy, containing an isoflavone derivative, and capable of treating hypoovarianism such as climacteric disturbance or infertility by enhancing the action of estrogen. CONSTITUTION:A remedy for hypoovarianism obtained by incorporating a compound of the formula (R is H, or lower alkyl), e.g. 7-hydroxy-isoflavone; white or yellowish brown crystal compound, soluble readily in dimethylformamide (DMF), etc., somewhat easily in ethanol, etc. and sparingly in water. The compound of the formula individually has no action of estrogen (hereinafter abbreviated to E) but effect on enhancement of the E action and is capable of enhancing the overial E action with reduced secretion in patients with climacteric disturbance or infertility and usable for treating the diseases. The dose thereof is 1-30mg/ kg/day, preferably 5-10mg/kg/day for oral administration and administered once a day. The dose is, if necessary, divided into two or three portions.
Neosporin will be distributed by the Yale Investigational Pharmacy. Subjects are to use Neosporin twice a day for 7 days.
Ticagrelor is associated with more prompt and potent antiplatelet effects compared with clopidogrel, leading to better clinical outcomes, including reduced cardiovascular mortality, across the spectrum of patients with acute coronary syndrome, including those with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). However, in this latter setting a delay in the onset of its antiplatelet effects has been shown. Morphine has been identified as a cause of delayed P2Y12 inhibition in patients with STEMI. In fact, opiates are known to inhibit gastric emptying, leading to delayed absorption and potentially decreasing peak plasma levels of orally administered drugs. Methylnaltrexone is a parenteral peripheral opioid receptor antagonist which has the potential to prevent or reverse opioid-induced peripherally mediated side effects (i.e. gastric emptying inhibition) without affecting analgesia. Studies have shown that methylnaltrexone effectively prevented morphine-induced gut motility change. However, whether the use of intravenous methylnaltrexone may overcome the effects of morphine administration on the pharmacokinetic (PK) and pharmacodynamics (PD) profiles of ticagrelor has not been investigated yet. The proposed investigation will include patients with coronary artery disease and will have a prospective, randomized, cross-over design. Patients will be randomized to receive either intravenous methylnaltrexone or placebo. Immediately after methylnaltrexone administration, patients will receive intravenous morphine and then will receive a 180-mg ticagrelor loading dose 15 minutes after morphine administration. After a 7 ± 2 days wash-out period, patients will cross-over to the alternate study-treatment arm. At each visit, blood samples for PK and PD assessments will be collected at several time points. This study will provide insights on a possible treatment strategy to overcome the impaired P2Y12 inhibition induced by morphine.