anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The recognition of sensory signals from within the body (interoceptive) and from the external environment (exteroceptive), along with the integration of these cues by the central nervous system, plays a crucial role in maintaining metabolic balance. This orchestration is vital for regulating processes related to both food intake and energy expenditure. Animal model studies indicate that manipulating specific populations of neurons in the central nervous system which influence these processes can effectively modify energy balance. This body of work presents an opportunity for the development of innovative weight loss therapies for the treatment of obesity and type 2 diabetes. In this overview, we delve into the sensory cues and the neuronal populations responsible for their integration, exploring their potential in the development of weight loss treatments for obesity and type 2 diabetes. This article is the first in a series of Perspectives that report on research funded by the American Diabetes Association Pathway to Stop Diabetes program.
BACKGROUND: Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be determined. We aimed to estimate the population attributable fraction of death from ARDS (PAFARDS) in hypoinflammatory and hyperinflammatory sepsis, and to determine the primary cause of death within each phenotype.
METHODS: We studied 1737 patients with sepsis from two prospective cohorts. Patients were previously assigned to the hyperinflammatory or hypoinflammatory phenotype using latent class analysis. The PAFARDS in patients with sepsis was estimated separately in the hypo and hyperinflammatory phenotypes. Organ dysfunction, severe comorbidities, and withdrawal of life support were abstracted from the medical record in a subset of patients from the EARLI cohort who died (n = 130/179). Primary cause of death was defined as the organ system that most directly contributed to death or withdrawal of life support.
RESULTS: The PAFARDS was 19% (95%CI 10,28%) in hypoinflammatory sepsis and, 14% (95%CI 6,20%) in hyperinflammatory sepsis. Cause of death differed between the two phenotypes (p < 0.001). Respiratory failure was the most common cause of death in hypoinflammatory sepsis, whereas circulatory shock was the most common cause in hyperinflammatory sepsis. Death with severe underlying comorbidities was more frequent in hypoinflammatory sepsis (81% vs. 67%, p = 0.004).
CONCLUSIONS: The PAFARDS is modest in both phenotypes whereas primary cause of death among patients with sepsis differed substantially by phenotype. This study identifies challenges in powering future clinical trials to detect changes in mortality outcomes among patients with sepsis and ARDS.
Lidocaine and tetracaine cream 7% / 7% is a topical local anesthetic cream that forms a pliable peel on the skin when exposed to air. The drug formulation is an emulsion in which the oil phase is a 1:1 eutectic mixture of lidocaine 7% and tetracaine 7%. The eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals.

The net weight of lidocaine is 2.1 g and of tetracaine is 2.1 g per 30 g tube.

Lidocaine, an amide local anesthetic, is chemically designated as acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl) and has an octanol:water partition ratio of 182 at pH 7.3. The molecular weight of lidocaine is 234.3, and the molecular formula is C 14H 22N 2O. The structural formula is: 

Tetracaine, an ester local anesthetic, is chemically designated as 2-dimethylaminoethyl 4-n-butyl-aminobenzoate and has an octanol:water partition ratio of 5370 at pH 7.3. The molecular weight of tetracaine is 264.4, and the molecular formula is C 15H 24N 2O 2. The structural formula is: 

Each gram of lidocaine and tetracaine cream contains lidocaine 70 mg and tetracaine 70 mg in a 1:1 eutectic mixture and it also contains the following inactive ingredients: anhydrous dibasic calcium phosphate, methylparaben, polyvinyl alcohol, propylparaben, purified water, sorbitan monopalmitate, and white petrolatum.
Gemcitabine on Day 1 followed by Oxaliplatin on Day 2. The regimen is given every 2 weeks to a maximum of 12 cycles.
Carboplatin, Pemetrexed and Bevacizumab are given day 1 every 3 weeks for 6 cycles and will be continued if patient tolerates treatments and has stable disease. The Bevacizumab will be continued every 3 weeks for 1 year if the patient tolerates treatment and has stable disease.
A portable device capable of communicating with a patient monitoring device is disclosed. The portable device comprises a processor configured to receive medical content presented by the patient monitoring device. The medical content is associated with physiological parameters of a patient monitored using the patient monitoring device. The processor emulates the medical content for presentation. A display of the portable device is configured to present the emulated medical content to the user. The portable device is also configured present guidance information received from the patient monitoring device. The user can access the guidance information for operating the patient monitoring device through the portable device.
FIELD: medicine, microbiology. SUBSTANCE: invention relates to the development of diagnosticum designated for identification of E. coli 0157:H7 for epidemiological inspection and diagnosis of hemorrhagic colitis. Diagnosticum comprises a carrier and sensitine. As a carrier the diagnosticum comprises polystyrene latex stained by lipid-soluble blue antraquine dye with activated amino-groups having particles size 0.502 mcm, variation coefficient is 4.1-4.5%, dispersion coefficient is 1.003-1.005, concentration of amino-groups is 2.3 x (10 -3  - 10 -4 ) mole/g and as sensitine the diagnosticum comprises protein A and rabbit immunoglobulins showing specificity raised to polysaccharide fraction LPS 0157 and protein flagellar antigen H7. For preparing the indicated diagnosticum 1-% suspension of preliminary washed out particles used as a carrier of polystyrene latex is incubated with protein A in concentration 55 mcg/ml as a sensitine in their equal ratio 1:1 and then washed out particles are incubated with rabbit specific immunoglobulins raised to polysaccharide fraction of lipopolysaccharide 0157, protein flagellar antigen H7 in concentration 180 mcg and 210 mcg, respectively, in their volume ratio 1:1. After incubation latex particles are treated with glycine buffer at pH 8.2 and incubated repeatedly. The prepared diagnosticum presents 0.5-% suspension of latex particles that are bound covalently with indicated rabbit specific immunoglobulins. Diagnosticum can be used for laboratory diagnosis of hemorrhagic colitis and for identification of E. coli 0157: H7 in foodstuffs. EFFECT: high sensitivity and specificity of diagnosticum. 2 cl, 2 tbl
FIELD: biotechnology.SUBSTANCE: invention relates to the field of microbiology and pertains to a method for cultivating toxocara larvae for diagnosing toxocariasis in cats. The substance of the method consists in the fact that eggs are embedded in 0.9% saline solution, the preparation is washed with saline solution into a Petri dish, the suspension is subjected to thermostating and centrifugation at a temperature of 39 to 40° for 7 hours with periodic stirring. In the course of evaporation, 0.9% saline solution is added, and after holding in a thermostat, 2% glutamine is added to the suspension in an amount of 1.5 g/2.5 ml. Further, in the process of changing the stages of larvae formation, at the stage of mobile larvae, the dosage of glutamine is increased to 1.9 g. 125 mg of nystatin and 250 mg of amoxicillin are therein added to the suspension at the initial stage of larval development once every 3 to 5 days. The preparations are added at intervals of 45 minutes. Then, in the process of larvae cultivation, after adding nystatin and amoxicillin and further in the course of activation of objects suppressed by nystatin and amoxicillin, the resulting suspension is daily exposed to an infrared lamp for 25 to 35 minutes for 4 weeks until 95% of the specimens are stabilised, followed by settling the suspension containing invasive mobile T.cati larvae in egg shells for 18 hours. To destroy the egg shell, an ultrasonic disintegrator microprobe with a voltage of 20 kHz is placed in the resulting precipitate for 15 minutes, and after the L2 stage larvae of feline toxocara are released from the egg shell structures, the resulting culture is centrifuged for 10 minutes.EFFECT: invention provides a possibility of cultivating toxocara eggs in a short time with a maximum yield of viable larvae.3 cl, 1 ex
PURPOSE:To provide the titled material adhesive to biological hard tissues, especially teeth, comprising a novel acrylate compound, specific polymer and radical initiator. CONSTITUTION:The objective adhesive film-forming material comprising (A) a novel acrylate compound of formula I (R1 and R3 are each H or alkyl, R2 is alkylene; n is 1 or 2) (e.g. a compound of formula II or III), (B) pref. 0.3-5pts. wt. per pt.wt. of the component A, of a polymer having both carboxyl group and polymerizable unsaturated double bond (e.g. a polymer containing monomer unit of formula IV), and (C) pref. 0.1-2wt% based on the whole monomer, of a radical initiator (e.g. diacetyl, benzoin methyl ether). The novel compound of the formula I can be prepared by reaction, for example, between a vinyl compound of formula V (Z is OH or halogen) and an alcohol compound of formula VI.
The application relates to a group of inventions, which are unitary, with technical relationship between the two inventions, method- 1 and method- 2. Method- 1- Three new ecological antimicrobial, antiviral extract preparations of natural products are invented: extract- (A)- from walnut leaf, extract- (B)- from specific vine leaves and extract- (C)- a mixture of the two extracts. This is an opportunity the chemical preparations to be replaced by ecologically biopreparations (Fig. 5). Method- 2- a new type constructive-biotechnological andmounth system is invented, where trough a wall (fence) (Fig. 1 and Fig. 2) is prevented the passing of infected animals and the virally infected wind flow is directed at an angle in order to fall in depth walnut plantation, which is sprayed with antiviralextracts- (Fig. 5)- for inactivation and destruction of the viral infection. Besides its ecologically-biological essence, the invention provides a perspective for economic and industrial development as a result of the existence and development of a comprehensive, synergistic, constructive-biotechnological system.
Transplantation of porcine xenografts into human recipients is a realistic option to overcome the growing worldwide shortage of suitable allogeneic organs. However, there remains the risk of infection by porcine endogenous retroviruses (PERVs) that cannot be eliminated like that by other microorganisms by breeding pigs under specified pathogen free conditions. To reduce the release of PERVs by porcine transplants a new approach, RNA interference (RNAi), was applied. Here we show significant reduction of PERV expression by synthetic short interfering RNAs (siRNAs) corresponding to different parts of the viral genes gag, pol and env. The most inhibitory sequences were selected and expressed as short hairpin RNAs (shRNAs) by a polymerase III vector system leading to persistent suppression of PERV replication. Cells or organs from transgenic pigs producing such shRNAs should increase the safety of xenotransplantation.
The capsule is stable in storage in a concentrated medium and on dilution is ruptured by slight mechanical stressing. Its core is completely enclosed by a matrix. The core is surrounded by multilayers. The casing includes a layer which is bonded electrostatically or covalently with the adjacent layer(s). Layer(s) are applied by solids coating and by membrane-forming fluid coating. At least one layer is formed by coating and complex formation. The core is a spherical droplet formed by precipitation, ionic effects or a temperature gradient. An oil or other material non-miscible with it, e.g. a hydrocarbon or hydrocarbon mixture, surrounds immobilized material in the core matrix. The substance to be immobilized forms a suspension with a second substance in the capsule interior, which forms a phase boundary with the matrix material. Other corresponding forms, e.g. a fluid/fluid emulsion or a solid phase are described. Cells or microorganisms may be contained in the core. Coating is carried out in a fluidized bed or flowing bed process. During drying in this process, additional solid is blown in. This forms a membrane on the capsule surface. All substances involved are food-compatible. Further variants and developments of the microcapsule are described in accordance with the foregoing principles.
The neurobiological underpinnings of gender differences in pain perception, and how these differences may be modified by age, are incompletely understood, placing patients at risk of suboptimal pain management. Using functional magnetic resonance imaging, we examined brain responses in the descending pain modulatory system (DPMS, specifically, dorsolateral prefrontal cortex, anterior cingulate cortex, insula, hypothalamus, amygdala, and periaqueductal gray, during an evoked pain task. We investigated the interaction of age and gender in our sample of healthy adults (27 females, 32 males, 30-86 years) on DPMS response. In a perceptually matched thermal pain paradigm, we investigated pain unpleasantness and neural responses for 3 heat pain percepts: just noticeable pain, weak pain, and moderate pain (MP). Females reported just noticeable pain at a lower temperature, but reported less unpleasantness at weak pain and MP percepts, compared to males. There was a significant age-by-gender interaction during moderate pain in the right anterior cingulate cortex and bilateral insula, such that, males had a stronger positive relationship between DPMS response and age compared to females in these regions. Our results indicate that differences in DPMS responses may explain some gender differences in pain perception and that this effect may change across the adult lifespan. PERSPECTIVE: Gender differences in pain have been well-documented but the brain mechanisms for these differences are still unclear. This article describes potential differences in brain functioning during different levels of pain that could explain differences in pain responses between men and women across the adult lifespan.
The Rehabilitation treatment group will receive rehabilitation training once per day, 3 days per week, for 12 weeks. The duration of each session is about 1 hour. Participants will first receive relaxation exercises, positioning and self-stretch exercises (emphasizing on spinal mobility and flexor muscle groups of limbs and trunk) for 15 minutes. Then they will have balance training for 20 minutes. The investigators will use goal-directed tasks, such as different types of ball games, for balance training. At the end, participants will receive walking exercise for 20 minutes, and cool down exercises for 5 minutes.
The embodiment of the invention provides a doctor-patient common decision proxy negotiation method and device based on a genetic algorithm, and relates to the technical field of doctor-patient common decisions. The doctor-patient common decision agent negotiation method comprises steps S1 to S4. S1, acquiring preference information of doctors and patients. Wherein the preference information includes weights and utility functions of doctors and patients for various negotiation topics. S2, constructing a doctor Agent proxy model and a patient Agent proxy model according to preference information of doctors and patients. Wherein the proxy model comprises an opponent model constructed based on a genetic algorithm. S3, constructing an SDM automatic negotiation model by adopting an alternative quotation protocol according to the doctor Agent model and the patient Agent model. S4, performing simulation negotiation according to the SDM automatic negotiation model to obtain a negotiation result. The method can express uncertainty information of the user. And effectively predicting opponent information to construct an opponent model, and optimizing and negotiating model performance by using the opponent model. The negotiation success rate and convergence speed are good.
Stress and stress-associated disease are considered the health epidemic of the 21st century. Interestingly, despite experiencing similar amounts of stress than those falling ill, some individuals are protected against the "wear and tear of daily life". Based on the notion that mindfulness training strengthens stress resilience, we explored whether facets of trait mindfulness, prior to training intervention, are linked to acute psychosocial stress reactivity and chronic stress load. To assess different mindfulness facets, over 130 participants completed the Five Facet Mindfulness Questionnaire (FFMQ) and the Freiburg Mindfulness Inventory (FMI). For acute stress induction, a standardized psychosocial stress test was conducted. Subjective stress, sympathetic and parasympathetic activity, and levels of the hypothalamic-pituitary-adrenal axis end hormone cortisol were assessed repeatedly. Additionally, levels of hair cortisol and cortisone as indices of the long-term physiological stress load were collected. We found differential associations of different facets of mindfulness with subjective stress, cortisol, and hair cortisone levels. Specifically, the trait mindfulness facets FMI "Acceptance" and the ability to put one's inner experience into words (FFMQ "Describing") were associated with lower acute subjective and cortisol stress reactivity. Contrarily, monitoring-related trait mindfulness facets (FFMQ "Acting with Awareness" and "Observing") were associated with higher acute cortisol and marginally higher long-term cortisone release. Our results suggest granularity of the mindfulness construct. In accordance with the "Monitor and Acceptance Theory", especially acceptance-related traits buffered against stress, while monitoring-related traits seemed to be maladaptive in the context of stress. The current results give valuable guidance for the conceptualization of mindfulness-based interventions geared towards stress reduction.
Pediatric patients usually experience high levels of pain and distress due to venipuncture. This randomised study aimed to evaluate the effects of virtual reality-based preprocedural education in comparison with video-based education in terms of pain and distress experienced by children scheduled to undergo venipuncture. Ninety children aged 4-8 years who were scheduled to undergo venipuncture surgery were randomly assigned to either a video or virtual reality group. Children in the video group received preprocedural education on venipuncture via a video displayed on a tablet and those in the virtual reality group received the same education via a head-mounted virtual reality display unit. The educational content for the two groups was identical. An independent assessor blinded to the group assignment observed the children's behavior and determined their Children's Hospital of Eastern Ontario Pain Scale scores, parental satisfaction score, procedure-related outcomes, venipuncture time, number of repeated procedures and difficulty score for the procedure. The virtual reality group experienced less pain and distress, as indicated by their Children's Hospital of Eastern Ontario Pain Scale scores compared with the video group (5.0 [5.0-8.0] vs. 7.0 [5.0-9.0], P = 0.027). There were no significant intergroup differences in parental satisfaction scores or procedure-related outcomes. For pediatric patients scheduled to undergo venipuncture, preprocedural education via a head-mounted display for immersive virtual reality was more effective compared with video-based education via a tablet in terms of reducing pain and distress.
Various treatment modalities have been applied to atrophic scars. Fractional CO2 laser treatment has attracted increasingly more attention because of its quicker recovery time and fewer side effects. However, its limitation of sculpting the edge is an urgent shortcoming. In order to achieve a more effective result with fewer complications, we have integrated ultrapulse CO2 and fractional CO2 lasers to for the treatment of facial atrophic scars. The study included 25 patients (10 males and 15 females) diagnosed with moderate to severe atrophic scars between August 2020 and July 2022. All subjects underwent the same surgical treatment. The effects were assessed at baseline, 1 week, 1 month, and 3 months using photographic evidence. Objective evaluation of the results was conducted using a quartile grading scale, while the subjects' satisfaction and any adverse events were also recorded. The patients in the study underwent more than two laser sessions (2-5), resulting in substantial improvement in their appearance. The time interval between each session was 3-6 months. The majority of the patients (19/25, 76%) had a significant or even excellent improvement. Any adverse events observed, such as erythema, superficial crusting, and PIH, were of a mild nature and temporary in duration. This treatment combined two CO2 lasers is an effective and safe choice for atrophic scars in Asians.
The safety of Panretin® gel has been assessed in clinical studies of 385 patients with AIDS-related KS. Adverse events associated with the use of Panretin® gel in patients with AIDS-related KS occurred almost exclusively at the site of application. The dermal toxicity begins as erythema; with continued application of Panretin® gel, erythema may increase and edema may develop. Dermal toxicity may become treatment-limiting, with intense erythema, edema, and vesiculation. Usually, however, adverse events are mild to moderate in severity; they led to withdrawal from the study in only 7% of the patients. Severe local (application site) skin adverse events occurred in about 10% of patients in the U.S. study (versus 0% in the vehicle control). Table 2 lists the adverse events that occurred at the application site with an incidence of at least 5% during the double-blind phase in the Panretin® gel-treated group and in the vehicle control group in either of the two controlled studies. Adverse events were reported at other sites but generally were similar in the two groups.

  


TABLE 2: Adverse Events with an Incidence of at Least 5% at the Application Site in Either Controlled Study in Patients Receiving Panretin® Gel or Vehicle Control 

To report SUSPECTED ADVERSE REACTIONS, contact Concordia Pharmaceuticals at 1-877-370-1142 or FDA at 1-800-FDA-1800 or www.fda.gov/medwatch
PURPOSE: To obtain an aqueous solution of a clathrate complex stable to hydrolysis which is formed by combining, which a dextrin, an organic ion compound instable to hydrolysis, esp. a mono- or bis-quaternary pryidinium compound. CONSTITUTION: A storage-stable aqueous solution is obtained by forming a clathrate complex stable to hydrolysis by use of a cyclodextrin in combination with an organic ion compound instable to hydrolysis. The organic ion compound is a quaternary pyridinium oxime of the formula [R1 is a 2- or 4-substituted oxime substituent, being CH=NOH; R2 is a 3- or 4-substituent such as CH= NOH, NC(CH3 )2 or SC2 H5 ; R3 is O or H2 ], esp. quaternary pyridinium oxime or aldoxime to be used in treating nervous poisoning due to organophophorus; while the dextrin is 2-hydroxypropyl β-cyclodextrin. The above aqueous solution is produced using a hypodermic autoinjector.