anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Idiopathic intracranial hypertension is a neurological condition characterized by a raised intracranial pressure and papilledema, leading to chronic headaches and visual disturbances. By recognizing modifiable risk factors and deploying evidence-based interventions, healthcare providers have the potential to mitigate the burden of the disease and improve patient outcomes.
AREAS COVERED: It is well known that the condition occurs in predominantly pre-menopausal females who live with obesity particularly in the context of recent weight gain. This review discusses what risk factors may contribute to the metabolic underpinnings of cerebrospinal fluid dysregulation. There are a number of disease associations that are important to screen for as they can alter management.
EXPERT OPINION: There is emerging evidence to suggest that idiopathic intracranial hypertension is a systemic metabolic disease and it is unknown what are all the risk factors are that precipitate the condition. Targeting certain hardwired risk factors is unachievable. However, as recent weight gain has been identified as a predominant risk factor for the development of the disease and relapse, modification of body weight should be the primary aim of management. Insightful research into the involvement of the neuroendocrine axis driving cerebrospinal fluid dysregulation now has the potential for the development of therapeutic targets.
Systems and methods are disclosed for generating a personalized care path for a patient. The method includes receiving, by one or more processors, relevant data associated with the patient from a plurality of data sources. The relevant data includes demographic data and medical data associated with the patient. The one or more processors using a graph convolutional neural network-based model determine the personalized care path for the patient based on the relevant data associated with the patient. The graph convolutional neural network-based model is trained based on a plurality of care paths of a plurality of patients represented by a patient-bucket-procedure (PBP) graph. The one or more processors provide data associated with the determined personalized care path for the patient to a device associated with a user.
To disclose a dye dispensing device including a controller and a tray.SOLUTION: The tray communicates with a controller 116 and is configured with at least one opening. At least one canister is configured with an identifier and a dye. The dye is associated with the identifier. A reader communicates with the controller 116. A dispenser comprises an actuator communicating with the controller 116 and a lever arm. The lever arm is coupled to the actuator and configured with a projection. The reader, based on the identifier, identifies a selected dye in a selected canister associated with a dye formulation. When the selected canister is positioned at a dispensing area, the dispenser applies a downward force to the selected canister and dispenses the selected dye.SELECTED DRAWING: Figure 2
PROBLEM TO BE SOLVED: To prepare an emulsion-type skin ointment having an excellent moisture retention by including a specified amount of oleic acid triglyceride. SOLUTION: This emulsion-type skin ointment includes 1.0-6.5wt.%, especially 2.5-5.5wt.% oleic acid triglyceride based on the total skin ointment. The oleic acid triglyceride is existing in a vegetable fat and oil such as Camellia sasanuqua, camellia, avocado, almond and sesame oils, a mink oil and a beef tallow and the one obtained by linking an oleic acid to glycerin with an ester bond can be also used. A dosage form of the emulsion-type skin ointment is e.g. an emulsified liquid, a cream and a lotion. The emulsion-type skin ointment can be blended with a base component such as vaseline, a surfactant such as a fatty acid monoglyceride, etc., in addition to the oleic acid triglyceride and according to demand of a use, the dosage form, a purpose, etc.
Innate inflammation promotes tumor development, although the role of innate inflammatory cytokines in established human tumors is unclear. Herein, we report clinical and translational results from a phase Ib trial testing whether IL1β blockade in human pancreatic cancer would alleviate myeloid immunosuppression and reveal antitumor T-cell responses to PD1 blockade. Patients with treatment-naïve advanced pancreatic ductal adenocarcinoma (n = 10) were treated with canakinumab, a high-affinity monoclonal human antiinterleukin-1β (IL1β), the PD1 blocking antibody spartalizumab, and gemcitabine/n(ab)paclitaxel. Analysis of paired peripheral blood from patients in the trial versus patients receiving multiagent chemotherapy showed a modest increase in HLA-DR+CD38+ activated CD8+ T cells and a decrease in circulating monocytic myeloid-derived suppressor cells (MDSC) by flow cytometry for patients in the trial but not in controls. Similarly, we used patient serum to differentiate monocytic MDSCs in vitro and showed that functional inhibition of T-cell proliferation was reduced when using on-treatment serum samples from patients in the trial but not when using serum from patients treated with chemotherapy alone. Within the tumor, we observed few changes in suppressive myeloid-cell populations or activated T cells as assessed by single-cell transcriptional profiling or multiplex immunofluorescence, although increases in CD8+ T cells suggest that improvements in the tumor immune microenvironment might be revealed by a larger study. Overall, the data indicate that exposure to PD1 and IL1β blockade induced a modest reactivation of peripheral CD8+ T cells and decreased circulating monocytic MDSCs; however, these changes did not lead to similarly uniform alterations in the tumor microenvironment.
The invention provides a method and means for dietary control. <??>The method provides information to a person under dietary prior and during a meal regarding item positioned before the person in real time. <??>The system comprises in combination a video photographic means connected to a computer provided with a suitable database and further provided with a display unit connected to the computer. <IMAGE>
It will include 30 patients of both sexes, recovered from COVID-19 infection. In addition to medical drugs, they will receive respiratory training for 6 weeks.
The invention provides a preparation method of traditional Chinese medicine for curing middle energizer intrinsic heat type hyperthyroidism, belonging to the technical field of a traditional Chinese medicine preparation method. In the prior art, the cure of the middle energizer intrinsic heat type hyperthyroidism generally adopts propylthiouracilum and can have the maculopapule prurigo and the constitutional symptom such as the fever. The technical scheme of the preparation method comprises the steps of: taking 23 traditional Chinese medicines such as gypsum, rhizoma anemarrhenae, cape jasmine, radix trichosanthis, rhizoma phragmitis, lotus plumule, pig bile, nightshade, vivipara, ampelopsis japonica, cynanchum atratum, solanum vine, Chinese honey locust, momordica grosvenori, caragana sinica rehd, coloured crotalaria herb with root, kelp, sargassum, concha arcae, concha meretricis seu cyclinae, bryozoatum, bamboo shavings and scutellaria baicalensis; putting the raw materials in 1100ml of water to soak for 35min; decocting by slow fire for 30min; and filtering out medicine dreg to obtain 560ml of medicine liquid, i.e. the traditional Chinese medicine for curing the middle energizer intrinsic heat type hyperthyroidism. The traditional Chinese medicine has the advantage that the poor effects caused by the application of the western medicine are avoided. Furthermore, the middle energizer intrinsic heat type hyperthyroidism is cured or improved.
Drugs that interfere with serotonin reuptake, including levomilnacipran, may increase the risk of bleeding events. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anticoagulants may add to this risk. Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. Based on data from the published observational studies, exposure to SNRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Use in Specific Populations (8.1)]. Bleeding events related to SSRIs and SNRIs have ranged from ecchymosis, hematoma, epistaxis, and petechiae to life-threatening hemorrhages.

Inform patients about the increased risk of bleeding associated with the concomitant use of levomilnacipran and NSAIDs, aspirin, or other drugs that affect coagulation [see Drug Interactions (7.1)].
Oral baricitinib is given at a dose of 2 mg daily for 6 consecutive months. Dexamethasone is administrated at 40 mg per day for 4 consecutive days (the 4-day course of dexamethasone will be repeated in the case of lack of response by day 10). Treatment will be discontinued if very severe or life-threatening adverse events developed or at the patients' request.
The ketogenic diet (KD) and regular exercise (EX) are both capable of orchestrating circadian metabolism homeostasis during losing weight. However, the combined effects of these two factors on circadian metabolism remain poorly understood. To determine if the combined treatment yields a superimposed physiological phenotype, we measured weight loss, white adipose, the respiratory exchange ratio (RER), heat production, and activity parameters in individual and combined treatment groups. Surprisingly, none of these metrics displayed a cumulative effect when administered in the combined treatment approach. Additionally, we investigated the impact of combination therapy on molecular homeostasis through using high-throughput liver transcriptomic approaches. The results revealed that individual and combined treatments can reprogram the circadian rhythm; yet, the combined group exhibited a minimum quantity of cyclic transcript genes. Noteworthy, the amplitude of 24 h circadian expression genes was not significantly increased in the combination treatment, indicating that the combined approach has non-overlapping effects on maintenance peripheral metabolism homeostasis. This may be due to the liver requiring less ketogenic and gluconeogenic potential during metabolic processes. This research suggests that combined treatment may have adverse effects on the body's homeostasis and provide crucial insights for the homeostatic health of athletes or individuals who wish to lose weight.
The LUM Imaging Device will not be used to guide additional tissue removal. Patients in this arm will receive the study drug, LUM015.
BACKGROUND/AIM: The global obesity epidemic has seen a dramatic increase in prevalence since 1975, posing significant health and economic challenges worldwide. Robotic-assisted single anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) has emerged as a promising surgical intervention for morbid obesity, offering potential advantages over traditional laparoscopic approaches in terms of precision, safety, and recovery outcomes. This study aimed to evaluate the efficacy and safety of robotic-assisted SADI-S, focusing on perioperative and postoperative outcomes including intraoperative complications, operative time, conversion rates, mortality, length of hospital stay, weight loss, and postoperative complications.
MATERIALS AND METHODS: A comprehensive literature search was conducted on PubMed, Scopus, and Cochrane Library, adhering to inclusion and exclusion criteria focused on obese adult humans undergoing robotic SADI-S. Seven studies, published between 2015 and 2024, involving 204 patients, were ultimately included for analysis.
RESULTS: The analysis revealed a low rate of intraoperative complications (0.49%), no mortality, and varied operative times (138 to 205.7 min). The median hospital stay ranged from 2 to 6.7 days, with minimal readmission rates. Postoperative complications occurred in 6.37% of patients, but no late complications (>30 days) were reported. Notably, significant weight loss outcomes were documented, with mean excess weight loss (EWL) up to 113.74% at 24 months follow-up.
CONCLUSION: Robotic-assisted SADI-S demonstrates a favourable safety profile with promising weight loss outcomes, highlighting its potential as a primary or revisional treatment for morbid obesity. Further research, including randomized controlled trials, is needed to establish its long-term efficacy and cost-effectiveness compared to traditional laparoscopic methods.
A system for storing medical records (15) which is comprised of a global communications network (12), a personal computer or terminal (14) linked to the global communications network (12) including a first connection port and a portable data access device connected to the first connection port is disclosed. The portable storage device preferably contains a processor, a memory, and an input device. An electronic patient record (15) is also disclosed. The patient record is carried by the portable data access device and may be updateable via the global communications network (12), the personal computer (14), or the input device acting in communication with the storage device. The patient record (15) contains personal patient information, such as disease/treatment history, and health insurance/medication information. The storage device may also generate patient reminders instructing a patient to schedule appointments. The input device is used to log into the portable device or terminal (14).
Manifestations of amphetamine overdose include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia and rhabdomyolysis. Fatigue and depression usually follow the central nervous system stimulation. Serotonin syndrome has also been reported. Cardiovascular effects include arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Fatal poisoning is usually preceded by convulsions and coma.

Treatment 

Consult with a Certified Poison Control Center for up to date guidance and advice.

TREATMENT

Consult with a Certified Poison Control Center for up-to-date guidance and advice. Management of acute amphetamine intoxication is largely symptomatic and includes gastric lavage, administration of activated charcoal, administration of a cathartic, and sedation. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Acidification of the urine increases amphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. If acute, severe hypertension complicates amphetamine overdosage, administration of intravenous phentolamine (Bedford Laboratories) has been suggested. However, a gradual drop in blood pressure will usually result when sufficient sedation has been achieved.

Chlorpromazine antagonizes the central stimulant effects of amphetamines and can be used to treat amphetamine intoxication.

Since much of the dextroamphetamine sulfate extended-release capsule medication is coated for gradual release, therapy directed at reversing the effects of the ingested drug and at supporting the patient should be continued for as long as overdosage symptoms remain. Saline cathartics are useful for hastening the evacuation of pellets that have not already released medication.
An extract for abstaining from addiction to drugs, its composition, as well as process and quality control method thereof. The extract is extracted from stephania delavayi diels. The raw materials of the composition are radix ginseng, stephania delavayi diels, radix astragali, radix angelicae sinensis and radix ophiopogonis. The composition also can be prepared by using ethanol extract of radix ginseng, ethanol extract of radix angelicae sinensis, alkaloid of stephania delavayi diels, water extract of radix astragali and water extract of ophiopogonis. The quality control method of the composition include one or more of identification and content measurement. The use of the extract, the composition in the manufacture of a medicine for abstaining from addiction to drugs.
Self-monitoring of blood glucose (SMBG) can both facilitate and hinder adherence in patients with diabetes mellitus (DM). Readings provide real-time information on hypoglycemic and hyperglycemic excursions. These data are crucial to successfully managing this disease, as SMBG can help guide decisions on titrating medications, and can potentially encourage patient engagement. There are drawbacks. Piercing the skin to check glucose up to several times a day can be uncomfortable and obtrusive for a patient with DM. SMBG offers only a snapshot of the patient's glucose at the time of testing.

Continuous glucose monitoring (CGM) can reveal glucose trends. A subcutaneous sensor transmits interstitial glucose readings approximately every five minutes. Yet, sensor insertion requires a needle. Patients still must test SMBG about 4 times per day to calibrate the CGM sensor. This modality is less accurate with low or rapidly rising glucose. CGM is also not widely available, due to cost and insurance issues. A non-invasive glucose monitor, the GlucoWatch, was discontinued due to problems with accuracy and tolerability.

Compounding these challenges is the surging number of individuals with DM. Every 19 seconds, an American 20 years of age or older is diagnosed with DM. If current trends continue, 1 in 3 Americans could have DM by 2050.

There is thus an unmet need for a non-invasive glucose monitoring device. UCSD nanoengineers developed a flexible, ultra-thin sensor adherent to the skin, similar to a temporary tattoo. Preliminary data from seven individuals without DM demonstrated correlation between glucose measurements from this sensor and a glucometer. Evaluating this sensor in patients with DM will be critical: while hour-to-hour blood glucose fluctuates approximately 50% throughout the day in those without DM, it may vary up to 10-fold in patients with DM. This study would be the first to examine this sensor in individuals with DM. The investigators hypothesize that compared with a glucometer, a tattoo sensor can accurately measure glucose in patients with DM.
OBJECTIVE: To investigate if predictors of wound complications differed between patients undergoing excision and primary anastomosis urethroplasty (EPA) and augmented urethroplasty.
METHODS: The National Surgical Quality Improvement Program database from 2006 to 2018 was queried for male patients undergoing urethroplasty. Thirty-day wound complications were identified and categorized (superficial/deep/organ-space surgical site infections and dehiscence). Multivariable logistic regression was performed to determine risk factors associated with wound complications. Smoking history was defined as current smoker within the past year.
RESULTS: Urethroplasty was performed in 2251 males, with 25.46% (n = 573) using a flap or graft. There was no significant difference in wound complications for patients undergoing augmented urethroplasty (n = 17, 2.97%) or EPA (n = 45, 2.68%) (p = 0.9). The augmented group had a higher BMI, longer operative time, and longer length of stay. On multivariable logistic regression, risk factors associated with wound complications for patients undergoing EPA were diabetes (OR 2.56, p = 0.03) and smoking (OR 2.32, p = 0.02). However, these factors were not associated with wound complications in patients undergoing augmented urethroplasty.
CONCLUSIONS: Smoking and diabetes were associated with increased wound complications for men undergoing EPA, but not in patients undergoing augmented urethroplasty. Patients with comorbidities associated with worse wound healing may be more likely to have a wound complication when undergoing EPA.
This invention “Optimized Biomass Combustion (Burning) for Renewing Ecosystem, Environment, and Atmosphere” is a process in which pure cow ghee is burned using sticks of specific trees along with other biomass such as dried cow dung cakes, grains, metal dust, herbs, etc., in a specially designed open brazier (combustion chamber). The amount of ghee, biomass, dimensions of the combustor, and length of time depends on the purposes that are given below. Reduce indoor air pollution and outdoor (ambient) air pollution caused by vehicles, and industries. Reduce rainwater and waterbodies pollution, curtail agriculture soil pollution. Mitigate intensities of hurricanes, storms, and tornadoes. Recovery from droughts, suppression of forest wildfires, mitigate virus/bacteria count, increase immunity, and reduce mosquitoes (and mosquito eggs) in the proximity.
Preparation of plant extract, from the leaves of Prunus lusitanicus using organic or inorganic solvents, partic. water, trichloroethylene, benzene, petroleum ether, ether, chloroform and ethanol. Fungicide, bactericide. Air-dried leaves of Prunus lusitanicus are ground to a fine powder which is suspd. in water. The suspn., pref. consisting of 8 parts powder to 100 parts water, is allowed to soak whilst stirring for 48 hrs. The mixture is then steam-distilled, and the distillate collected in an ice-bath.
INTRODUCTION: Controversy remains as to whether pathologic complete response (pCR) and major pathologic response (MPR) represent surrogate end points for event-free survival (EFS) and overall survival (OS) in neoadjuvant trials for resectable NSCLC.
METHODS: A search of PubMed and archives of international conference abstracts was performed from June 2017 through October 31, 2023. Studies incorporating a neoadjuvant arm with immune checkpoint blockade alone or in combination with chemotherapy were included. Those not providing information regarding pCR, MPR, EFS, or OS were excluded. For trial-level surrogacy, log ORs for pCR and MPR and log hazard ratios for EFS and OS were analyzed using a linear regression model weighted by sample size. The regression coefficient and R2 with 95% confidence interval were calculated by the bootstrapping approach.
RESULTS: Seven randomized clinical trials were identified for a total of 2385 patients. At the patient level, the R2 of pCR and MPR with 2-year EFS were 0.82 (0.66-0.94) and 0.81 (0.63-0.93), respectively. The OR of 2-year EFS rates by response status was 0.12 (0.07-0.19) and 0.11 (0.05-0.22), respectively. For the 2-year OS, the R2 of pCR and MPR were 0.55 (0.09-0.98) and 0.52 (0.10-0.96), respectively. At the trial level, the R2 for the association of OR for response and HR for EFS was 0.58 (0.00-0.97) and 0.61 (0.00-0.97), respectively.
CONCLUSIONS: Our analyses reveal a robust correlation between pCR and MPR with 2-year EFS but not OS. Trial-level surrogacy was moderate but imprecise. More mature follow-up and data to assess the impact of study crossover are needed.
Double-Blind Study Phase (12 weeks): On Day 1, botulinum toxin Type A 300 U will be given by intramuscular injections into specified muscles of the lower limb, and an optional dose of 100 U may be injected into additional lower limb muscles. Open Label Study Phase: Up to 3 treatments with botulinum toxin Type A up to 400 U will be given by intramuscular injections to the lower limb approximately every 12 weeks over a 42 week period.