anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Poor diet, physical inactivity, and sedentary behaviors among low-income, minority populations have been linked to greater risk of chronic health conditions such as overweight/obesity, cardiovascular disease, and type 2 diabetes. Low-income clinics that serve these populations often represent an untapped opportunity for health promotion in impoverished individuals. Few studies have examined the feasibility of using brief physician advice and multi-level, clinic-based interventions to change poor dietary habits, physical inactivity, and sedentary lifestyle behaviors among these culturally diverse populations that comprise the clinic population. This exploratory project proposes to address this scientific gap by introducing and piloting a Self-Care Stimulating Disease Prevention Program (SCSDPP) to address poor dietary habits, physical inactivity, and sedentary lifestyle behaviors among low income, uninsured patient populations (primarily Latinos) served by the community clinics of the Venice Family Clinic (VFC) health center in Los Angeles County. The program will include the development of 1) a simple-to-use patient Health Priority Assessment (HPA) tool designed to assess patient preferences for behavior change; 2) a standard protocol for physicians to provide brief health advice using motivation interviewing (\< 2 minutes per visit); 3) a protocol for distributing self-help aids for patient use (e.g., pedometer, exercise videos); and 4) a series of monthly follow-up counseling sessions by lay health educators (e.g., promotores) to help patients address their lifestyle change priorities over time. We will conduct a randomized controlled pilot of the SCSDPP in approximately 100 patient cases at two community health clinics within the VFC health center system. The pilot will utilize precise outcome measures, including commonly-accepted biomarkers (e.g., HgbA1c, fasting blood glucose) and psychometrically-validated measures of process and health status, to accurately assess the magnitude of changes in diet and physical activity among patients over a 12-month observation period. The feasibility of integrating the SCSDPP into the community health clinic setting will be evaluated, and is the primary aim of this project. The results will inform efforts to plan a larger, successor study. Relevance to Public Health: this study evaluates a clinic-based brief intervention to help prevent overweight/obesity, a public health problem that has been linked to the development of the metabolic syndrome and other precursors of diabetes.
Participants will receive a 6-month regimen with oral ibandronate, 150 mg once monthly. Group 1 will receive a physician consultation after 4 months of treatment to review bone turnover test results.
This protocol seeks to analyze patient outcomes of two standard of care, time-efficient, monitored group exercise regimens of high-load resistance training to improve hypertrophy in women who have been treated for ductal carcinoma in situ or invasive carcinoma of the breast.

As part of the standard exercise program, patients will undergo a fitness evaluation at the AHNCI Exercise Oncology and Resiliency Center before the start of the exercise program. This evaluation will be used to customize the patient exercise program. The exercise program consists of small group training sessions held approximately 3 times per week at the center for 12 weeks (3 months). The fitness evaluation and exercise program are standard of care. Participation in this study will last the duration of the exercise program, about 3 months. All group exercise sessions will be closely monitored by the center staff who are Certified Strength and Conditioning Specialists (CSCS).
Prospective memory allows us to remember to perform an action in the future in response to environmental cues (event-based) or predetermined times (time-based). It is often impaired in individuals with mild cognitive impairment. These deficits are related to various cognitive functions such as episodic memory and executive functions and are particularly affected in pathological ageing. In this article, we propose a literature review of non-pharmacological interventions with the elderly with MCI and neurodegenerative diseases. This article explores different strategies for managing prospective memory, including cognitive training, mnemonic strategies, and external aids. In all cases, it is important to design personalized interventions that take account of patients' individual characteristics. Research into the long-term effectiveness of these strategies is still limited, and further studies are needed to properly assess their benefits.
PURPOSE:The titled promoter consisting essentially of a bile acid. CONSTITUTION:A lipid metabolic promoter for fishes consisting essentially of a bile acid, e.g. hydroxy acid, cholic acid, deoxycholic acid or lithocholic acid of steroid which is derived from cholanic acid as a parent material. The above- mentioned promoter promotes the absorption of lipid through the small intestine by dissolving the promoter in water or mixing it with a feed for natural or forced administration, or promotes the excretion of lipid deposited on the surface of the body or internal organs to the outside of the body and improves the health of the fishes. The above-mentioned promoter has a wide range of effective dose, and the bile acid is present originally in the animal bodies without side effects. Thus, the lipid metabolism can be promoted with a high percentage of success.
Angiotensin II (Ang II) is formed by the action of angiotensin-converting enzyme (ACE) in the renin-angiotensin system. This hormone is known to induce cardiac hypertrophy and heart failure and its actions are mediated by the interaction of both pro- and antihypertrophic Ang II receptors (AT1R and AT2R). Ang II is also metabolized by ACE 2 to Ang-(1-7), which elicits the activation of Mas receptors (MasR) for inducing antihypertrophic actions. Since heart failure under different pathophysiological situations is preceded by adaptive and maladaptive cardiac hypertrophy, we have reviewed the existing literature to gain some information regarding the roles of AT1R, AT2R, and MasR in both acute and chronic conditions of cardiac hypertrophy. It appears that the activation of AT1R may be involved in the development of adaptive and maladaptive cardiac hypertrophy as well as subsequent heart failure because both ACE inhibitors and AT1R antagonists exert beneficial effects. On the other hand, the activation of both AT2R and MasR may prevent the occurrence of maladaptive cardiac hypertrophy and delay the progression of heart failure, and thus therapy with different activators of these antihypertrophic receptors under chronic pathological stages may prove beneficial. Accordingly, it is suggested that a great deal of effort should be made to develop appropriate activators of both AT2R and MasR for the treatment of heart failure subjects.
The invention belongs to the technical field of molecular virology and immunology, and provides an alpaca source nano antibody specifically combined with Human Papilloma Virus (HPV) and application thereof, wherein the alpaca source nano antibody is provided with a heavy chain variable region (VHH) which comprises the following CDRs: CDR1 with an amino acid sequence shown as SEQ ID NO. 1, CDR2 with an amino acid sequence shown as SEQ ID NO. 2 and CDR3 with an amino acid sequence shown as SEQ ID NO. 3, wherein the VHH comprises 4 framework regions of FR1-4, and the FR1, FR2, FR3 and FR4 and the CDR1, CDR2 and CDR3 are staggered in sequence. The nano antibody can effectively inhibit HPV pseudovirus infection. The HPV nano antibody has clinical application value in prevention, treatment and/or detection of HPV infection.
A system includes a computer system, data storage media and a user application. The user application is associated with a user device. The processing device is in communication with the user application and includes an account creation module, an event creation module and an event trigger module defined by the computer program. The account creation module allows a user to create a user account using the user interface of the user application. The event creation module allows the user to access a user account and to create an event associated with the user account. The event includes an event trigger and digital asset access information associated with a digital asset. The event trigger module performs the steps of receiving an indication that the event trigger has occurred and responsively providing access to the digital asset to a recipient using the digital asset access information.
Baseline measurement will be done in the rehabilitation center. Prescription for rehabilitation will be determined based on the result of baseline measurement. Participants will be given instruction how to do proper exercise training at home. Participants will attend a regular check up at the center once a month. After 12 weeks post intervention measurement will be taken.
AIMS: This study aims to evaluate the histopathological features and prognostic parameters of tumors with microsatellite instability (MSI) compared with those without MSI in patients who underwent surgery for colorectal cancer (CRC).
SETTING AND DESIGN: Follow-up for CRC at Istanbul Sultan 2. Abdulhamid Han Training and Research Hospital was retrospectively evaluated between March 2017 and March 2021.
METHODS AND MATERIAL: The patients were divided into two groups: those with and without MSI. Groups were compared in survival parameters. As a secondary result, groups were compared in pathological parameters such as stage, tumor diameter, degree of differentiation, and lymphovascular, and perineural invasion.
STATISTICAL ANALYSIS USED: Survival calculations were performed using the Kaplan-Meier analysis method. The effects of various prognostic factors related to tumor and patient characteristics on disease-free and overall survival (OS) were investigated by log-rank test.
RESULTS: Two hundred fourteen patients were analyzed. The median age of the patients was 66 (30-89), and 59.3% (n = 127) were male. There were 25 patients in the MSI group and 189 patients in the non-MSI group. We found that MSI tumors had a significantly higher differentiation degree than non-MSI tumors and larger tumor diameters. MSI tumors frequently settled in the proximal colon, and more lymph nodes were removed in the resection material. MSI tumors had longer disease-free survival, cancer-specific survival, and overall survival.
CONCLUSIONS: By diagnosing microsatellite instability, CRCs can be divided into two groups. The histopathological features of the tumor and the prognosis of the disease differ between these groups. MSI can be a predictive marker in the patient's follow-up and treatment.
The present disclosure relates to methods and compositions to ameliorate or treat at least one symptom of colorectal cancer and/or adenomatous polyposis coli (APC). For example, some embodiments of the methods and compositions may reduce recurrence of colorectal adenomas and/or extend the life of a subject having colorectal cancer and/or APC. Some embodiments of the disclosure include maintaining the total body weight in a subject having colorectal cancer and/or APC. According to some embodiments, a method of the disclosure may include administering a bile acid composition to a subject. A bile acid composition may include, in some embodiments, an aqueous solution that is free or substantially free of precipitates or particles. An aqueous solution may include (1) a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and/or 7-ketolithocholic acid, (2) a carbohydrate, and (3) water. An aqueous composition may further include an alkali.
In controlled clinical trials, the effectiveness of piroxicam has been established for both acute exacerbations and long-term management of rheumatoid arthritis and osteoarthritis.

The therapeutic effects of piroxicam are evident early in the treatment of both diseases with a progressive increase in response over several (8–12) weeks. Efficacy is seen in terms of pain relief and, when present, subsidence of inflammation.

Doses of 20 mg/day piroxicam display a therapeutic effect comparable to therapeutic doses of aspirin, with a lower incidence of minor gastrointestinal effects and tinnitus.

Piroxicam has been administered concomitantly with fixed doses of gold and corticosteroids. The existence of a "steroid-sparing" effect has not been adequately studied to date.
STABLE NUTRITIVE AND THERAPEUTIC FLAX SEED COMPOSITIONS, METHODS OF PREPARING THE SAME, AND    THERAPEUTIC METHODS EMPLOYING THE SAME               ABSTRACT OF THE DISCLOSURE A method for producing a stable dry composition of flax seed comprising grinding the flax seed in the presence of vitamin B-6 and zinc ion at a temperature of about 160°F to just above freezing.  A stable dry composition   of   flax   seed   produced   by   the aforementioned  method.   A method  for producing  a stable  emulsion  or suspension of flax  seed comprising:  (1)   grinding the  flax  seed  in  the presence of vitamin B-6 and zinc ion at a temperature of about 160°F to just above freezing;  (2)  soaking the flax seed in an aqueous solution for about 10 minutes to overnight at a temperature of about 160°F to just above freezing; and   (3)   blending    or homogenizing said soaked, ground flax seed, with or without further additives, to form a stable emulsion or suspension; provided that the steps (1)  and (2) can be conducted in any order.  A stable emulsion or suspension of flax seed.  A method of lowering serum triglycerides    and/or    cholesterol   comprising administering a therapeutically effective amount of the stable emulsion or suspension of flax seed.  A method  of  treating  the  symptoms  of  psoriasis comprising  administering  topically  to  an  affected area the stable emulsion or suspension of flax seed.
Blood specimens will be obtained for the model-assigned high risk cohort at each collaborating HCO, over two years of recruitment period. Data of each participant will be electronically followed for observation of outcome measures for up to 3 years.
The presentation of relevant data to users during a surgical procedure is disclosed. A system may include a plurality of displays present in an operating room. A medical personnel database may store data related to roles of users. A role gesture database may store gestures that may be made to store and retrieve data during the surgical procedure, based on respective roles of the users. A display tracking module may identify locations of the plurality of displays present in the operating room. A user tracking module may identify locations of the users and the occurrence of corresponding gestures of the users present in the operating room, to determine an identity of the user present in proximity to a display of the plurality of displays, and to display data related to the identity of the user based on a gesture during the surgical procedure.
A system and method for delivering patient information and clinical assistance. Information and related digest reports are delivered at a point in the care team workflow prior to patient arrival. Information is extracted from scheduling data and electronic health record information. Digest reports are generated by the inventive system on a daily or other customizable basis, and profile upcoming patients scheduled to be seen by a healthcare team or team member. Patient information compiled and delivered by the inventive system may include historical data and ongoing patient condition and complaints stored electronically outside of the inventive system. Clinical assistance compiled and delivered to the user may include published clinical guidelines and other clinical recommendations. The system and method of its use have the capacity to aid in the user's adherence to governmental criteria, and in the attainment of value based care goals. These goals may include care coordination, test-tracking, patient follow-up, and other clinical decision support needs that are currently not automated in an efficient manner. Health care providers may save time and money with the system, and are able to to manage an ever increasing burden of patient information more accurately effectively to treat their patients. Customizations of digest reports including specific types of information and data may be generated to accommodate individual healthcare practice group needs as well as value-based care models.
The process comprises intradermal immunisation with a mixt. of 3 vol. of HBs antigen, partly purified (1/64) and 3 vol. of Freund additive; intramuscular administration after 30 days of 5 vol. of partly purified antigen and, after a further 30 days, of 10 vol. of partly purified HBs antigen, is then carried out. Then, 7, 14 and 16 days after the final inoculation the serum obtained is adsorbed with an equal volume of human serum contg. anti HBs antibodies of up to 1.2 titre.
The invention relates to a method for directing a user (2) to a subject (1) in need of care, the method being of a controller of an electronic device. As a step (S1) the method comprises an outputting of information (i1) on the subject (1) in need of care to the user (2). In another step (S2) information on a current location of the user (2) are obtained. A further step (S3) is determining a route from the current location to a location of the subject (2) and in another step (S4) navigation information (n1, n2) is output based on the determined route to the user (2). Another aspect of the invention is a system comprising a controller configured to perform the method, at mobile device (20) and localisation means (30). The invention further relates to a controller that is configured to perform the inventive method and to a mobile device (20) comprising such a controller.
This is an open-label, multicenter, phase 2b, randomized study aiming to compare the efficacy and safety of venetoclax plus azacytidine Versus daunorubicin plus cytarabine (conventional 7+3 regimen) in adult acute myeloid leukemia (AML) patients with adverse risk featuress. Newly diagnosed AML patients with adverse risk features according to 2022 European Leukemia Net risk stratification will be enrolled. In the study, a novel second generation targeted sequencing panel for the fast screening of adverse mutations with 72-hours after the bone marrow samples will be utilized. Randomized participants will receive induction treatment . Participants will be 1:1 randomly assigned to the VA and DA groups. VA regimen comprises of azacytidine, 75mg/m2, subcutaneously, on days 1-7; venetoclax, orally, once a day, 100mg, d1; 200mg, d2; 400mg, days 3-28. DA regimen comprises of daunorubicin (60mg/m2) on days 1-3, intraveneously injection, and cytarabine (100mg/m2) on days 1-7, intraveneously injection, for 1 cycle. Once remission was achieved, consolidated chemotherapy will be performed and allogeneic hematopoietic stem cell transplantation is strongly recommended. After completion of the study intervention, participants will be followed-up every 1 to 2 months for up to 2 years.
OBJECTIVE: This study aimed to determine the impact of pregnancy weight gain above National Academy of Medicine (NAM) guidelines on cesarean delivery rates following induction.
STUDY DESIGN: This is a secondary analysis of a prospective cohort study of patients who underwent induction at a single tertiary care center between July 2017 and July 2019. Included in the primary study were patients undergoing term (≥37 weeks) labor induction with a singleton gestation, intact membranes, and unfavorable cervical examination (Bishop score of ≤6 and cervical dilation ≤ 2 cm). Eligibility for this analysis was limited to patients with a documented prenatal body mass index (BMI) < 20 weeks' gestation. The primary exposure was gestational weight gain greater than NAM guidelines (WGGG) for a patient's initial BMI category. The primary outcome was cesarean delivery for any indication.
RESULTS: Of 1,610 patients included in the original cohort, 1,174 (72.9%) met inclusion criteria for this analysis and 517 (44.0%) of these had weight gain above NAM guidelines. Of the entire cohort, 60.0% were Black and 52.7% had private insurance. In total, 160 patients (31%) with WGGG underwent cesarean compared with 127 patients (19.3%) without WGGG (p < 0.001), which equates to a 59% increased odds of cesarean when controlling for initial BMI category, parity, gestational diabetes, and indication for induction (Adjusted Odds Ratio [aOR] 1.58, 95% confidence interval [CI] 1.17-2.12). Among only nulliparous patients, WGGG was associated with an increased odds of cesarean (26.4 vs. 38.2%, aOR 1.50, 95% CI 1.07-2.10). In multiparous patients, however, there was no difference in cesarean between those with and without WGGG (8.8 vs. 14.1%, aOR 1.85, 95% CI 0.96-3.58).
CONCLUSION: This study demonstrates that weight gain above NAM guidelines is associated with more than a 50% increased odds of cesarean. Patients should be informed of this association as gestational weight gain may be a modifiable risk factor for cesarean delivery.
KEY POINTS: · Weight gain above NAM guidelines was associated with a 59% increased odds of cesarean delivery.. · Nulliparous patients with weight gain above NAM guidelines are at higher risk of cesarean delivery.. · No difference in cesarean delivery among multiparous patients regardless of gestational weight gain..
PROBLEM TO BE SOLVED: To obtain a cosmetic containing a colored pigment in a specific amount and useful as a skin color cosmetic. SOLUTION: This cosmetic contains 0.5-4.0wt.% of a coloring agent (e.g. titanium dioxide or zinc oxide), and has an appearance color comprising a hue of 5R to 10YR, a brightness of 3.0 to 8.5, and a chroma of 1.5-10.0 in Munsell color system. The coloring agent is preferably subjected to a water- repelling treatment comprising dispersing the coloring agent in the solution of a silicone oil (e.g. cyclic dimethyl polysiloxane) in a proper volume of hexane, etc., removing the solvent, treating the residue at 100-200 deg.C for 2-10hr and subsequently drying the treated agent. The cosmetic has a transparent appearance and simultaneously can correct the color tone of skin to finish the skin beautifully and naturally. The cosmetic can further give a bare skin touch excellent in the sense of use.
Patients assigned to the intervention group (60) will: 1) use the personalized mobile phone app in their preferred language for a duration of 6 months; and 2) receive assistance from a patient navigator. They will also continue to receive the usual EHT care provided at the MCC's breast clinic.
Preoperative antibiotic selection, method or preparation, draping, or technique;. the corpora, scrotum, and reservoir space will be irrigated with Irrisept only immediately after the space is created in all cases. An additional scrotal irrigation with Irrisept only after all components are placed will be performed, as well. The patients will be followed and monitored for penile prosthesis infection as well as any other surgical complications for 1 year post operatively.