anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To facilitate setting of a received light quantity, and a return operation to the initial state after light emission, by providing a means for automatically varying a received light quantity level which stops a flash in response to flash light emission, to a prescribed value. CONSTITUTION:An electric power supply E1charges a main capacitor C1 through a charging current limiting resistance R22. When charge voltage reaches a prescribed value, an indicating neon lamp Ne is turned on. After it has been turned on, when a synchro-contact X is turned on, a xenon flash lamp Xe emits light. A photodetector TR4 makes an optical current flow in accordance with the quantity of reflection from an object to be photographed, and stops light emission of the lamp Xe through a voltage comparator IC1. When the contact X is turned on three thims at short prescribed intervals, one-shot multivibrators OS1, OS2 and OS3 are operated, capacitors C8, C9 are charged, and voltage for variably controlling a received light quantity level to a prescribed value automatically at every flash can be applied to the comparator IC1. Also, after a prescribed time has passed by flash light emission, it can be returned to the initial state automatically.
Subjects who are randomized to this arm will receive treatment for 39 weeks and post-treatment followup for 65 weeks. Participants may take as long as 47 weeks to complete all doses of a 39-week treatment regimen. Dosing of experimental regimens will be oral and weight based. Subjects will undergo a linezoilid dose reduction randomization to either 300mg daily or 600mg three times a week after 16 weeks of treatment or after a linezolid-related AE requiring dose reduction, whichever is earlier.
In the first 2 weeks, sessions were held with all patients once a week. In these two sessions, the basic information of scoliosis were explained to both groups. Postural corrections were explained to the patients, including the basic elements of clinical pilates.It was stated that they should breathe towards the concave side of the major curve (weak breathing zone) during exercises and postural corrections.In the Pilates-based exercise program, sessions are planned as 10 minutes of warm-up, 10 minutes of cool-down and 40 minutes of scoliosis-specific pilates-based exercises for approximately 1 hour. Total number of exercises is 12 for one session. After a 2-week joint training week, the training group switched to hybrid type telerehabilitation and continued their exercise sessions with a physiotherapist 3 days a week via synchronous video conferences (Zoom Application) and by themselves at home on the rest of the week.
Epidemiological evidence of familial predispositions to myeloid malignancies and myeloproliferative neoplasms (MPN) has long been recognised, but recent studies have added to knowledge of specific germline variants in multiple genes that contribute to the familial risk. These variants may be common risk alleles in the general population but have low penetrance and cause sporadic MPN, such as the JAK2 46/1 haplotype, the variant most strongly associated with MPN. Association studies are increasingly identifying other MPN susceptibility genes such as TERT, MECOM, and SH2B3, while some common variants in DDX41 and RUNX1 appear to lead to a spectrum of myeloid malignancies. RBBP6 and ATM variants have been identified in familial MPN clusters and very rare germline variants such as chromosome 14q duplication cause hereditary MPN with high penetrance. Rarely, there are hereditary non-malignant diseases with an MPN-like phenotype. Knowledge of those genes and germline genetic changes which lead to MPN or diseases that mimic MPN helps to improve accuracy of diagnosis, aids with counselling regarding familial risk, and may contribute to clinical decision-making. Large scale population exome and genome sequencing studies will improve our knowledge of both common and rare germline genetic contributions to MPN.
PROBLEM TO BE SOLVED: To obtain a slimming agent comprising the extract of a non- photosynthetic mold and useful for beauty treatments for obtaining the topical or whole slimming and/or thinning effects of the skins or styles of human being or animals. SOLUTION: This slimming agent comprises at least one extract of at least one non-photosynthetic mold. It is preferable that the extract contains lipopolysaccharides in a large amount. The mold preferably belongs to the order Beggiatoales (preferably the genus Beggiatoa, Vitreoscilla, Flexithrix or Leucothrix). The mold extract is preferably contained in an amount of 0.1-80 wt.% based on the total amount of the composition. The composition preferably contains the mold extract and a compound selected from among medicines for controlling the transfer of fatty acids, neuropeptide Y(NPY) antagonists capable of blocking neuropeptide Y(NPY) receptors on fat cells, such as the extracts of plants or bacteria, β-adrenalinep-like agonists, glucose transfer agonists, etc.
PURPOSE:To obtain the title investment material by blending a mixture of cristobalite of refractory and/or quartz and hemihydrate of binder with natural starch and a specific transition metal compound as an expanding agent and aluminum phosphate as a cast cavity inhibitor. CONSTITUTION:100 pts.wt. mixture of cristobalite of refractory and/or quartz and hemihydrate as binder is blended with 0.1-5 pts.wt. natural starch and 0.1-10wt.% one or more of carbide, nitride, boride, silicide and sulfide of transition metal of groups IV, V and VI of the periodic table as an expanding agent and aluminum phosphate as cast cavity inhibitor to give a gypsum-based investment material having large thermal expansion and improved heat resistance of gypsum. The investment material is preferably blended with 0.1-1 pt.wt. soluble starch. The investment material is safe because of no evolution of toxic gas.
Eligible subjects will be randomized to wavelength sequence 770 +/- 9nm/ 830 +/- 15nm/ 900 +/- 15nm. Within each wavelength, subjects will be further randomized to a pupil size sequence (3mm, 4mm, 6mm). Study endpoints will be measured at 3 different pupil sizes.
Adapt ePNa-CheXED for Instacares and after in silico testing, pilot it among "super user" clinicians during Instacare shifts and assess its usability. ePNa needs adaptation for more limited patient data available in Instacare clinics, calibration of severity measures for lower observed mortality, and a chest imaging prompt in patients with pneumonia signs and symptoms. ePNa-CheXED will incorporate Stanford University's artificial intelligence CheXED model to provide electronic classification of chest images in \<1 second for elements of pneumonia diagnosis and treatment (radiographic pneumonia, single vs multiple lobes, and pleural effusion).
Cold-inducible RNA binding protein (CIRBP), a stress response protein, protects cells from mild hypothermia or hypoxia by stabilizing specific mRNAs and promoting their translation. Neurons subjected to hypobaric hypoxia insult trigger various cell death programs. One of these is ferroptosis, a novel non-apoptotic form of programmed cell death, which is characterized by excessive iron ion accumulation and lipid peroxidation. Here, we establish that CIRBP can regulate neuronal ferroptosis both in vivo and in vitro. We observe that hypoxia leads to neuronal death via intracellular ferrous iron overload and impaired antioxidant systems, accompanied by suppressed CIRBP expression. Genetic enrichment of CIRBP in hippocampal neurons CIRBPTg mice bred with Emx1-Cre mice attenuates hypoxia-induced cognitive deficits and neuronal degeneration. Mechanistically, CIRBP alleviates neuronal ferroptosis and intracellular ferrous ion accumulation by binding to the mitochondrial ferritin (FTMT) 3'UTR to stabilize mRNA and promote its translation. Our novel study shows the critical role of CIRBP in the progression of ferroptosis, and provides promising therapeutic target for hypoxia-induced neurological diseases.
Patients receive \[18F\]FTT IV and undergo PET scan 60-75 minutes later on day 1 of initiating SOC PARP inhibitor ± ICI therapy and again at 12 weeks. At least 1-7 days later, patients undergo SOC FDG PET/CT and follow up scans at 12 weeks and 6 months. Patients may also undergo tissue biopsy during screening and during follow up.
BACKGROUND: The interplay between serum bicarbonate levels and kidney outcomes is not fully understood. We conducted a prospective cohort study in three intensive care units (ICUs) to evaluate the association of serum bicarbonate levels with acute kidney injury (AKI) and kidney function recovery in critically ill patients.
METHODS: A prospective cohort study in three intensive care units (ICUs) was performed. The serum bicarbonate level in the first 24 h after ICU admission was categorized as low (< 22 mEq/L), normal (22-26 mEq/L), or high (> 26 mEq/L). Serum creatinine (SCr) levels according to the KDIGO AKI guideline were used for defining AKI within the first 7 days of ICU stay. At ICU admission, SCr ≥ 1.1 for women and ≥ 1.3 mg/dL for men were indicative of impaired kidney function. Mortality outcome was tracked up to 28 days, and kidney function recovery was assessed at hospital discharge.
RESULTS: A total of 2732 patients (66 ± 19 years and 55% men) were analyzed, with 32% having impaired kidney function at ICU admission. Overall, 26% of patients had low bicarbonate levels, while 32% had high bicarbonate levels. Notably, patients with preserved kidney function showed a lower prevalence of low bicarbonate levels compared to those with impaired kidney function (20% vs. 39%, p < 0.001), while higher rates were observed for high bicarbonate (35% vs. 24%, p < 0.001). Compared with patients with normal serum bicarbonate levels, those with low bicarbonate were 81% more likely to develop AKI (OR = 1.81; 95% CI 1.10-2.99), whereas those with high bicarbonate were 44% less likely (OR = 0.56; 95% CI 0.32-0.98) in the adjusted model for confounders. Neither those with high nor low serum bicarbonate levels were associated with an increased risk of mortality (HR = 1.03; 95% CI 0.68-1.56 and 0.99; 95% CI 0.68-1.42, respectively). In subgroup analysis, regardless of the kidney function at ICU admission, serum bicarbonate levels were not associated with the development of AKI and all-cause mortality. Regarding kidney function recovery, higher non-recovery rates were found for those with low bicarbonate.
CONCLUSION: In critically ill ICU patients, low bicarbonate levels were associated with the more likely development of AKI and subsequent non-recovery of kidney function, while high bicarbonate levels showed no such association. Therefore, low bicarbonate levels may be considered a risk factor for adverse kidney outcomes in critically ill patients.
The invention provides traditional Chinese medicine externally applied preparation for treating psoriasis and a preparation method thereof. The traditional Chinese medicine externally applied preparation comprises the following traditional Chinese medicine raw materials with same weight: kuh-seng, Shrubalthea Barks, Argy wormwood leaves, Coptis chinensis, pericarpium zanthoxyli, Rhizoma et Radix Notopterygii, Angelica dahurica, Cimicifuga foetida, honeycombs, realgar, calcined alum and urea. The traditional Chinese medicine raw materials can also comprise dittany barks, Chinese angelica and Schizonepeta tenuifolia. The preparation method comprises the following steps: taking various traditional Chinese medicine raw materials with the same weight, adding water into the kuh-seng, the Shrubalthea Barks, the Argy wormwood leaves, the Coptis chinensis, the pericarpium zanthoxyli, the Rhizoma et Radix Notopterygii, the Angelica dahurica, the Cimicifuga foetida and the honeycombs first, cooking the raw materials for 3 times by the prior method, concentrating the raw materials into paste, adding water according to the proportion that 50 milliliters of water is added into each 1 gram of one packet of the traditional Chinese medicine raw materials, and placing the realgar, the calcined alum and the urea into the paste for uniform mixing. When the traditional Chinese medicine raw materials comprise the dittany barks, the Chinese angelica and the Schizonepeta tenuifolia, lotion can be prepared and decocted for scouring bath or bubble bath. The traditional Chinese medicine externally applied preparation is pure traditional Chinese medicine preparation, has low cost, has the functions of clearing away the heat-evil and expelling superficial evils, eliminating dampness and killing insects, regulates blood and qi and gives judicious guidance in the internal aspect, has catharsis function in the external aspect, treat both principal and secondary aspect of diseases.
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a complication of measles, occurring after a latency of 4-10 years. It continues to occur in developing countries although resurgence is being reported from developed countries. Characteristic features include progressive neuropsychiatric issues, myoclonus, seizures, movement disorders and visual impairment. Electroencephalography (EEG) typically shows periodic generalized discharges, and elevated CSF anti-measles antibodies are diagnostic. Movement disorders are being increasingly recognized as part of the clinical spectrum, and range from hyperkinetic (chorea, dystonia, tremor, tics) to hypokinetic (parkinsonism) disorders and ataxia.
OBJECTIVES: This article aims to comprehensively review the spectrum of movement disorders associated with SSPE.
METHODS: A literature search was conducted in PubMed and EMBASE databases in December 2023 and articles were identified for review.
RESULTS: Movement disorders reported in SSPE included hyperkinetic (chorea, dystonia, tremor and tics), hypokinetic (parkinsonism), ataxia and extraocular movement disorders. Myoclonus, a core clinical feature, was the most frequent "abnormal movement." Movement disorders were observed in all clinical stages, and could also be a presenting feature, even sans myoclonus. Hyperkinetic movement disorders were more common than hypokinetic movement disorders. An evolution of movement disorders was observed, with ataxia, chorea and dystonia occurring earlier, and parkinsonism later in the disease. Neuroradiological correlates of movement disorders remained unclear.
CONCLUSION: A wide spectrum of movement disorders was observed throughout the clinical stages of SSPE. Most data were derived from case reports and small case series. Multicentric longitudinal studies are required to better delineate the spectrum and evolution of movement disorders in SSPE.
The invention discloses a method for extracting ganoderma lucidum fruit body polysaccharides by using superpressure; the ganoderma lucidum fruit body polysaccharides are new endogenetic active materials extracted from the ganoderma lucidum fruit bodies. The ingredients of the ganoderma lucidum polysaccharides can improve the phagocytosis of phagocytes, the humoral immunity and cellular immune function, which can improve the SOD activity of superoxide dismutases in red blood cells in human bodies. However, the ganoderma lucidum cells are compact, and the polysaccharides are difficult to be extracted from ganoderma lucidum. The methods of extraction which are most used currently are defective. The method for extracting ganoderma lucidum fruit body polysaccharides comprises the steps of selecting ganoderma lucidum fruit bodies, adding extracting solution, sealing and immersing the ganoderma lucidum fruit bodies in the extracting solution, treating the ganoderma lucidum fruit bodies under superpressure, filtration and condensation, drying the condensed filtrate, getting the polysaccharides from the ganoderma lucidum fruit bodies. High temperature does not occur during the extraction; active ingredients in the ganoderma lucidum fruit bodies can be preserved; the extraction takes little time with high yield and low impurity content. In addition, some microbes can be killed through pressurization to complete extraction and sterilization at one step. The method for extracting ganoderma lucidum fruit body polysaccharides overwhelms the defects of the prior methods for extracting polysaccharides from ganoderma lucidum.
PULSE is a non-specific multi-component intervention in which participants will receive flexibility exercises, active range of motion (AROM) for the upper and lower extremities, breathing exercises, and transcutaneous electrical nerve stimulation (TENS). Participants receive 32 visits of approximately 60 minutes in duration from a study PT. Participants will receive up to three visits a week, on non-consecutive days, for 16 weeks. Visits will take place in the participant's place of residence. Participants will also receive the nutritional intervention for the duration of the 16-week study.
Children and adolescents who met the Diagnostic and Statistical Manual IV Text Revision (DSM-IV-TR) diagnostic criteria for ADHD and needed pharmacotherapy. Subjects will be taking Methylphenidate or Atomoxetine for 52 weeks.
The study of microcirculation can reveal important information related to pathology. Focusing on alterations that are represented by an obstruction of blood flow in microcirculatory regions may provide an insight into vascular biomarkers. The current in silico study assesses the capability of contrast enhanced ultrasound (CEUS) and super-resolution ultrasound imaging (SRU) flow-quantification to study occlusive actions in a microvascular bed, particularly the ability to characterise known and model induced flow behaviours. The aim is to investigate theoretical limits with the use of CEUS and SRU in order to propose realistic biomarker targets relevant for clinical diagnosis. Results from CEUS flow parameters display limitations congruent with prior investigations. Conventional resolution limits lead to signals dominated by large vessels, making discrimination of microvasculature specific signals difficult. Additionally, some occlusions lead to weakened parametric correlation against flow rate in the remainder of the network. Loss of correlation is dependent on the degree to which flow is redistributed, with comparatively minor redistribution correlating in accordance with ground truth measurements for change in mean transit time,dMTT(CEUS,R = 0.85; GT,R = 0.82) and change in peak intensity,dIp(CEUS,R = 0.87; GT,R = 0.96). Major redistributions, however, result in a loss of correlation, demonstrating that the effectiveness of time-intensity curve parameters is influenced by the site of occlusion. Conversely, results from SRU processing provides accurate depiction of the anatomy and dynamics present in the vascular bed, that extends to individual microvessels. Correspondence between model vessel structure displayed in SRU maps with the ground truth was>91%for cases of minor and major flow redistributions. In conclusion, SRU appears to be a highly promising technology in the quantification of subtle flow phenomena due ischaemia induced vascular flow redistribution.
Participants will receive 10-14 days of imipenem/cilastatin/relebactam every 6 hours with dose determined per renal function, with or without adjunctive aminoglycoside or fluoroquinolone therapy as determined by local study site. After receiving at least 3 doses (i.e. steady-state), a total of eight blood samples will be collected over one dosing interval to measure imipenem and relebactam concentrations. Data will be fit to a population pharmacokinetic model. The final model will be utilized in a Monte Carlo simulation to determine the probability of several different dosing regimens retaining both (1) free imipenem concentrations above the minimum inhibitory concentration (MIC) for at least 40% of the dosing interval and (2) free relebactam area under the concentration-time curve at least eight times greater than the MIC. These data will be utilized to determine an optimized dosing regimen for adults and adolescents with CF. Additionally, two weeks after treatment, as part of the exploratory clinical endpoint, patients will complete follow-up pulmonary function tests to determine relative percent increase in FEV1 and return to baseline FEV1 after treatment. These outcomes will be reported descriptively.
BACKGROUND: Ocular tension decreases with increasing postmortem interval (PMI) and eyes collapse with extreme progression of postmortem change; however, time-related changes in postmortem computed tomography (PMCT) findings have not been clarified. This study aimed to quantitatively evaluate the vitreous volume and CT values of the vitreous body to clarify time-related changes in PMCT.
METHODS: We retrospectively reviewed PMCT images of the eyes of subjects who underwent autopsy at our institution between July 2023 and February 2024. They were classified into four PMI groups: PMI-1: < 1 day, PMI-2: 1-2 days, PMI-3: 3-6 days, PMI-4: ≥ 7 days. The vitreous volumes and mean CT values of the vitreous chambers were measured. Additionally, the presence of intraocular gas and crystalline lens dislocation was observed.
RESULTS: The PMCT images of 131 eyes of 66 patients (41 males, 25 females) were analyzed. The mean age was 63.7 (22-99) years. The volume of the vitreous cavity was significantly decreased at PMI-3 and PMI-4, which indicated scleral depression. Intraocular gas appeared in PMI-4. Lens dislocation began at PMI-3 and was more frequently observed at PMI-4 and in the higher-temperature environment group.
CONCLUSION: Ocular findings on PMCT are useful for estimating the time of death.
The enfacement illusion is a facial version of the rubber hand illusion, in which participants experience tactile stimulation of their own faces synchronously with the observation of the same stimulation applied to another's face. In previous studies, participants have reported experiencing an illusory embodiment of the other's face following synchronous compared to asynchronous stimulation. In a series of three experiments, we addressed the following three questions: (i) how does similarity between the self and the other, operationalized here as being of the same or different gender to the other, impact the experience of embodiment in the enfacement illusion; (ii) does the experience of embodiment result from alterations to the self-concept; and (iii) is susceptibility to the experience of embodiment associated with interoceptive processing, i.e. perception of the internal state of the body? Results indicate that embodiment is facilitated by the similarity between the self and the other and is mediated by the incorporation of the other into the self-concept, but sensitivity to one's own internal states does not impact upon embodiment within the enfacement illusion. This article is part of the theme issue 'Minds in movement: embodied cognition in the age of artificial intelligence'.