anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Medical item identification information is stored in association with information indicating locations at which medical items are placed in a medical item tray. An RFID reader acquires tray identification information from an RFID tag on the tray. An RFID reader also acquires item identification information from an RFID tag on the medical item to be placed in the tray. A database stores medical item identification information in association with tray identification information and tray zone information. The tray zone information indicates particular zones of the tray in which particular items are to be placed. A computer processor processes the medical item identification information, the tray identification information and the tray zone information, and executes instructions to generate a first image depicting a type of medical item tray as indicated by the tray identification information, and a second image that depicts a zoomed in portion of the first image as indicated by the tray zone information.
This is a prospective, quality improvement study that evaluated critically ill patients initiated on intravenous vancomycin. Between January 2012 through October 2013, vancomycin was dosed at 15-20mg/kg at an interval guided by creatinine clearance using the Cockcroft Gault equation (control arm). Steady state trough concentrations were assessed prior to the 4th dose of a consistent regimen and compared to the individualized target trough range (10-15mg/L or 15-20mg/L) appropriate for the suspected or documented source of infection. Given low overall trough achievement observed with standard care, a quality improvement project was undertaken. After approval by local clinical practice committees with representation from the Division of Infectious Diseases, Pharmacy and Critical Care, a quality improvement project was undertaken to implement a new vancomycin dosing nomogram with dosing intervals based on the Chronic Kidney Disease Epidemiology Collaborative (CKD-EPI) creatinine-cystatin GFR equation, expressed in mL/min. After structured education was provided, the dosing algorithm was rolled out from December 2013 through May 2015 (intervention arm). Steady state target vancomycin trough achievement was compared between study arms with and without adjustment for potential confounders.
It is recommended that liver enzyme tests be performed before the initiation of CRESTOR, and if signs or symptoms of liver injury occur.

Increases in serum transaminases [AST (SGOT) or ALT (SGPT)] have been reported with HMG‑CoA reductase inhibitors, including CRESTOR. In most cases, the elevations were transient and resolved or improved on continued therapy or after a brief interruption in therapy. There were two cases of jaundice, for which a relationship to CRESTOR therapy could not be determined, which resolved after discontinuation of therapy. There were no cases of liver failure or irreversible liver disease in these trials. 

In a pooled analysis of placebo-controlled trials, increases in serum transaminases to >3 times the upper limit of normal occurred in 1.1% of patients taking CRESTOR versus 0.5% of patients treated with placebo. 

There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including rosuvastatin. If serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment with CRESTOR, promptly interrupt therapy. If an alternate etiology is not found, do not restart CRESTOR. 

CRESTOR should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease [see Clinical Pharmacology (12.3)]. Active liver disease, which may include unexplained persistent transaminase elevations, is a contraindication to the use of CRESTOR [see Contraindications (4)].
Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof. The benzoxazines (I) wherein Xb is halogen and R1 is H, alkyl or alkylene up to 6 C atoms or aryl, may be obtained by cyclazation of a compound having the formula (II) by reaction with triphenylphosphin and azodicarboxylate of ethyl. The compounds of formula (II) may be obtained by reaction of a compound (III) with an appropriate epoxy. By using the appropriate chiral epoxy, the enantiomerically desired intermediate may be obtained, and consequently it is possible to selectively obtain the desired final product with the appropriate enantiomer form without having to go through a resolution step. The compounds (I) are valuable and key intermediates for the synthesis of antimicrobial agents such as floxacin and levofloxacin. <CHEM>
To understand the role and stability of food derived bacteria in impacting microbiome composition, 20 healthy participants will be recruited for this single site double blinded randomised controlled crossover pilot trial. The study is divided into four 14 day diet phases - baseline habitual, specified diet 1, habitual washout and specified diet 2. Participants will be randomly assigned to receive a microbial or non-microbial diet in specified diet 1 phase. Each participant will then crossover to receive the alternative diet in the specified diet 2 phase. The microbial and non-microbial diets will be identical except for the removal of naturally occurring food derived bacteria in non-microbial diet. At the commencement of the study and at the end of each diet phase, participants will attend a research clinic to undergo comprehensive clinical and anthropometric assessment and dietary evaluation.
Adverse reactions with different phenothiazines vary in type, frequency and mechanism of occurrence, i.e., some are dose-related, while others involve individual patient sensitivity. Some adverse reactions may be more likely to occur, or occur with greater intensity, in patients with special medical problems, e.g., patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses of certain phenothiazines.

Not all of the following adverse reactions have been observed with every phenothiazine derivative, but they have been reported with 1 or more and should be borne in mind when drugs of this class are administered: extrapyramidal symptoms (opisthotonos, oculogyric crisis, hyperreflexia, dystonia, akathisia, dyskinesia, parkinsonism) some of which have lasted months and even years- particularly in elderly patients with previous brain damage; grand mal and petit mal convulsions, particularly in patients with EEG abnormalities or history of such disorders; altered cerebrospinal fluid proteins; cerebral edema; intensification and prolongation of the action of central nervous system depressants (opiates, analgesics, antihistamines, barbiturates, alcohol), atropine, heat, organophosphorus insecticides; autonomic reactions (dryness of the mouth, nasal congestion, headache, nausea, constipation, obstipation, adynamic ileus, ejaculatory disorders/impotence, priapism, atonic colon, urinary retention, miosis and mydriasis); reactivation of psychotic processes, catatonic-like states; hypotension (sometimes fatal); cardiac arrest; blood dyscrasias (pancytopenia, thrombocytopenic purpura, leukopenia, agranulocytosis, eosinophilia, hemolytic anemia, aplastic anemia); liver damage (jaundice, biliary stasis); endocrine disturbances (hyperglycemia, hypoglycemia, glycosuria, lactation, galactorrhea, gynecomastia, menstrual irregularities, false-positive pregnancy tests); skin disorders (photosensitivity, itching, erythema, urticaria, eczema up to exfoliative dermatitis); other allergic reactions (asthma, laryngeal edema, angioneurotic edema, anaphylactoid reactions); peripheral edema; reversed epinephrine effect; hyperpyrexia; mild fever after large I.M. doses; increased appetite; increased weight; a systemic lupus erythematosus-like syndrome; pigmentary retinopathy; with prolonged administration of substantial doses, skin pigmentation, epithelial keratopathy, and lenticular and corneal deposits.

EKG changes-particularly nonspecific, usually reversible Q and T wave distortions-have been observed in some patients receiving phenothiazine tranquilizers.

Although phenothiazines cause neither psychic nor physical dependence, sudden discontinuance in long-term psychiatric patients may cause temporary symptoms, e.g., nausea and vomiting, dizziness, tremulousness.

Note: There have been occasional reports of sudden death in patients receiving phenothiazines. In some cases, the cause appeared to be cardiac arrest or asphyxia due to failure of the cough reflex.
109 psoriasis patients, referred for UVB phototherapy, participated in our study after given their written informed consent. After determining the minimal erythema dose (MED) patients were randomised in either group 1, erythematogenic scheme, or group 2, suberythematogenic scheme. Group 1 started with 70% of MED and every following irradiation with an increase of 40%. Group 2 started with 30% of MED and every next visit an increase of 20%. The study protocol was adjusted in case of erythema (sunburn) according to a standard erythema-phototherapy protocol, varying from skip one irradiation to lowering the percentage of increase. In case of clearance the study stopped. Clearance was defined as less than 10% of baseline body area of psoriasis.
PURPOSE: Verb tense production is known to be impaired in people with nonfluent aphasia. Selective past tense impairment in this population has been reported, but results are inconsistent and lacking at the discourse level. In addition, language production can be affected by discourse elicitation tasks depending on the cognitive linguistic demands and instructions unique to each task. There is limited evidence regarding whether verb tense production in people with nonfluent aphasia is impacted by discourse task demands. Understanding this potential impact is important for clinicians and researchers who are interested in assessing and then identifying effective clinical goals for this population. Therefore, this study aimed to investigate the trends of verb tense production across various discourse elicitation tasks in people with nonfluent aphasia compared to people without aphasia.
METHOD: Language samples for 23 people with nonfluent aphasia and 27 people without aphasia were obtained for six discourse tasks from the AphasiaBank database. We calculated ratios of past tense, present tense, future tense, imperative, and unknown verb types to compare which tense was used most frequently within and across the tasks and groups.
RESULTS AND CONCLUSIONS: Our findings revealed evidence of verb tense production deficits and a selective past tense impairment in people with nonfluent aphasia. Discourse task effects were shown for people without aphasia but were scarce in people with nonfluent aphasia. This finding could be explained by an overall reduction of verb production and overreliance on present tense production in nonfluent aphasia. These results suggest the potential methodological implications of using different discourse tasks to evaluate verb tense production in people with nonfluent aphasia. Future studies need to evaluate discourse task effects on other aspects of verb production (e.g., moods) and specific task factors (e.g., presence or absence of visual stimulus).
SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25146242.
1. Couch Grass works on the prostate gland to clear it of bacteria. If this bacteria is allowed to build up it could cause arthritis neuralgia, cancer, and neurological, problems. The blood is cleaned by the Magistral Viagra and hormones are activated. Couch Grass is in the carrot family, it is potent. The potency of Couch Grass is 10 to 1 it is 10× more potent than carrots. It is very high in potassium.
         2. Stale Red Clover, quantity of herb to be used is, judged on the weight of 150 pound man. This herb contains ammonia fixing bacteria, it works on the kidneys. The sodium, potassium cells of the kidneys are activated. Salts and potassium cells of the kidneys are activated. Salts and potassium work on the gut to produce a super abundant amount of energy, water is the catalyst for the production of hormones in the blood. These hormones travel through out the body in the blood. They work on the principle of vasodilation and vasoconstriction. I want to focus on the vasoconstriction.   3. Skull Cap works on the body using the volatile fixed oils, (essential oil) The main color titrated out is green, green works on the heart. In the Contraction phase the heart rests. There are seven botanical herbs in the Magistral Viagra. The synergistic effect causes the free flow of hormones in Endocrine system, (duct-less glands) to operate efficiently. It helps to rid the body of diseased bacteria and gives the patient confidence in coitus.
BACKGROUND: Studies demonstrate associations between low social activity in older adults and cognitive decline. Little has been investigated regarding which factors are associated with low social activity in older adults at increased risk of dementia.
OBJECTIVE: We investigate which sociodemographic, psychological, health-related, and environmental factors are associated with low social activity in older adults at increased risk of dementia. Additionally, we describe the stages of health behavior change, the types of social activities, and the duration of the current level of social activity.
METHODS: We used baseline data of 1,015 participants from the AgeWell.de trial. We conducted logistic and Poisson regression analyses to investigate factors associated with low social activity. We report descriptive statistics on the stages of change in the sample, the types of social activities most frequently pursued, and the duration of the current level of social activity.
RESULTS: Lower income, non-usage of public transport, depressive symptoms, cognitive, mobility, and hearing impairment were negatively associated with social activity. The majority of the sample was in the maintenance stage, followed by the precontemplation stage. The most common social activities were traveling and hobbies with others. Participants have maintained their current level of social activity for several years.
CONCLUSIONS: We identified a lack of resources (income, transport), depressive symptoms and poorer health (cognitive, mobility and hearing impairment) as barriers to social activity. Interventions promoting social activity in older adults at risk of dementia may specifically target individuals with these risk factors. Low-threshold opportunities for social activity may be particularly beneficial.
The invention provides a linear antibacterial peptide, a preparation method and application thereof, and the sequence of the linear antibacterial peptide is shown in SEQ ID No. 1. The invention designs a hydrophilic-hydrophobic alternative peptide template (RXKY) based on a linear beta-folding principle 2 (YRY) 2 ‑NH 2 Wherein, X is hydrophobic isoleucine, Y is hydrophobic leucine, the antibacterial peptide is named as RIKL, and the sequence is shown in SEQ ID No. 1. The application of the antibacterial peptide RIKL in preparing medicaments for treating infectious diseases of gram-positive bacteria or/and gram-negative bacteria. The antibacterial peptide has very low hemolytic activity and eukaryotic cytotoxicity. The antibacterial peptide can not cause 10% of erythrocyte hemolysis under the concentration of 128 mu mol/L and the survival rate of mouse macrophage RAW264.7 reaches more than 80%.
1. Synthesis of bitter principle derivatives based on the denatonium structure according to formula (1). 2.1. The aim of the invention is to introduce couplable carboxylic acid functionalities into the denatonium structure by means of simple synthesis. 2.2. According to the invention, lidocaine derivatives are reacted with carboxylated benzyl halogenides. 2.3. The carboxylated denatonium derivatives are particularly applicable in medicine, biology and medical engineering, and in the cosmetic, pharmaceutical, chemical and food industries.
Patients receive STI-3031 intra-lymphatically via the DoseConnect device over 1-8 hours QW on days 1, 8, 15, 22, 29, and 36 of cycle 1, and Q2W on days 1, 15, and 29 of cycle 2. Treatment repeats every 42 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients with CR at the end of cycle 2 receive 1-2 additional cycles in the absence of disease progression or unacceptable toxicity. Patients with PR or SD at the end of cycle 2 continue treatment for a total of 9 cycles in the absence of disease progression or unacceptable toxicity.
PURPOSE: A cosmetic product containing urethane foam of an ether polymer type is provided to improve reaction stability and to enhance formulation stability, portability, and simplicity. CONSTITUTION: A cosmetic composition contains urethane foam of an impregnated ether polymer type. The urethane foam has a net structure. The density of the urethane foam is 1.0-3.0 pcf. The urethane foam has an open cell structure. The cosmetic composition is a emulsion of W/O type or O/W type. The cosmetic composition is manufactured in the form of a makeup primer, makeup base, foundation, skin cover, lip stick, face powder, lip liner pencil, eyebrow pencil, eye shadow, cheek color, compact powder, powder pact, eye brow, blusher, powder foundation, or airless formulation. [Reference numerals] (AA) EZ93N (polyether type 1); (BB) ZH100KT (polyester type 4]); (CC) ZH100LG (polyester type 5)
PURPOSE: To provide a new monoclonal antibody capable of inhibiting blood coagulation and recognizing neutral glycolipids, having high specificity to malignant tumor, exhibiting high sensitivity even to early malignant tumor and useful e.g. as an agent for detecting malignant tumor by using blood, urine, tissue, etc., as a specimen. CONSTITUTION: A female BALB/c mouse of 8 weeks old is immunized by injecting LK-52 cell originated from human squamous cell carcinoma into the peritoneal cavity of the mouse 4 times with 2 weeks interval. Spleen cell is collected from the mouse 3 days after the final injection and fused with a mouse myeloma cell using polyethylene glycol. The fused cell is selectively cultured on a HAT medium to obtain a hybridoma. The product is screened by using a neutral glycolipid extracted from LK-52 cell originated from human squamous cell carcinoma to select a strain producing an antibody having specificity to neutral glycolipid. The strain is cloned by limited dilution method, etc., and the obtained monoclonized hybridoma is cultured to obtain the objective new monoclonal antibody cable of inhibiting the coagulation of blood and recognizing neutral glycolipids.
Patients receive 90 mg/m\^2 paclitaxel IV over 1 hour on days 1, 8, and 15. Patients may receive 10 mg/kg bevacizumab IV over 30-90 minutes on days 1 and 15.
Human associated microorganisms (the microbiota) inhabit virtually all surfaces of the human body. The gut is densely colonized by the microbiota which aids in the digestion. Animal and human observational and experimental evidence show a link between gut microbiota and the activation, regulation and function of the immune system. Pre-clinical studies in mouse models have linked the gut microbiota to efficacy of anticancer therapies. Microbial Ecosystem Therapeutics (MET) is a new treatment approach developed as an alternative to fecal transplantation. MET consists of a defined mixture of pure live cultures of intestinal bacteria isolated from a stool sample of a healthy donor.

This study is designed to assess the safety, tolerability and engraftment (cumulative relative abundance) of MET-4 strains when given in combination with immune checkpoint inhibitors (ICIs).
This is a clinical trial study to evaluate and compare the effects of wrist ankle acupuncture and sham wrist ankle acupuncture as a therapy for post total hip arthroplasty pain. The subjects are 32 males/female who just undergone total hip arthroplasty surgery and has returned to inpatient ward. They will be randomly assigned to 2 groups: (1) wrist ankle acupuncture and (2) Sham wrist ankle acupuncture. The subjects will receive two sessions of treatment. The outcome will be assessed before treatment (baseline), after fist acupuncture session, after second acupuncture session and a day after the second session. Patients and the outcome assessors will be blinded to the group allocation.
PURPOSE OF REVIEW: The present study aims to review the existing literature to identify pathophysiological proteins in obesity by conducting a systematic review of proteomics studies. Proteomics may reveal the mechanisms of obesity development and clarify the links between obesity and related diseases, improving our comprehension of obesity and its clinical implications.
RECENT FINDINGS: Most of the molecular events implicated in obesity development remain incomplete. Proteomics stands as a powerful tool for elucidating the intricate interactions among proteins in the context of obesity. This methodology has the potential to identify proteins involved in pathological processes and to evaluate changes in protein abundance during obesity development, contributing to the identification of early disease predisposition, monitoring the effectiveness of interventions and improving disease management overall. Despite many non-targeted proteomic studies exploring obesity, a comprehensive and up-to-date systematic review of the molecular events implicated in obesity development is lacking. The lack of such a review presents a significant challenge for researchers trying to interpret the existing literature. This systematic review was conducted following the PRISMA guidelines and included sixteen human proteomic studies, each of which delineated proteins exhibiting significant alterations in obesity. A total of 41 proteins were reported to be altered in obesity by at least two or more studies. These proteins were involved in metabolic pathways, oxidative stress responses, inflammatory processes, protein folding, coagulation, as well as structure/cytoskeleton. Many of the identified proteomic biomarkers of obesity have also been reported to be dysregulated in obesity-related disease. Among them, seven proteins, which belong to metabolic pathways (aldehyde dehydrogenase and apolipoprotein A1), the chaperone family (albumin, heat shock protein beta 1, protein disulfide-isomerase A3) and oxidative stress and inflammation proteins (catalase and complement C3), could potentially serve as biomarkers for the progression of obesity and the development of comorbidities, contributing to personalized medicine in the field of obesity. Our systematic review in proteomics represents a substantial step forward in unravelling the complexities of protein alterations associated with obesity. It provides valuable insights into the pathophysiological mechanisms underlying obesity, thereby opening avenues for the discovery of potential biomarkers and the development of personalized medicine in obesity.
For three days, a combination of 500 mg of bitter melon fruit extract (Momordica charantia) and 325 mg of bitter melon fruit content (13.50 mg/kg body weight) was administered. those with Plasmodium falciparum and Plasmodium vivax malaria received a single dosage of primaquine (0.25 mg/kg body weight) once daily, with those with Plasmodium falciparum malaria receiving it for 14 days.
A placebo with an indistinguishable appearance and color. 3 times a day, 1 pack at a time, dissolve in warm water and take with meals or after meals.