anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention belongs to the technical field of tumor diagnosis. Disclosed in the present invention are circPOLK as a therapeutic target and diagnostic biomarker for tumors and the use thereof. The nucleotide sequence of circPOLK is as shown in SEQ ID NO: 10, and circPOLK is a circular RNA formed by means of the reverse splicing of the exons 1-3 of POLK mRNA. Compared with normal patients, circPOLK in the blood exosome in patients with tumors shows a high expression. The expression of circPOLK is positively correlated with the migration, invasion and metastasis capacity of lung cancer cells, and lung cancer cells can secrete circPOLK by means of exosomes to promote the migration and invasion capacity of vascular endothelial cells. Therefore, circPOLK can be used as a therapeutic target and diagnostic biomarker for tumors, providing a new school of thought and direction for the development of therapeutic drugs and diagnostic products.
In cholinergic urticaria (CholU), small, itchy wheals are induced by exercise or passive warming and reduced sweating has been reported. Despite the described reduced muscarinic receptor expression, sweat duct obstruction, or sweat allergy, the underlying pathomechanisms are not well understood. To gain further insights, we collected skin biopsies before and after pulse-controlled ergometry and sweat after sauna provocation from CholU patients as well as healthy controls. CholU patients displayed partially severely reduced local sweating, yet total sweat volume was unaltered. However, sweat electrolyte composition was altered, with increased K+ concentration in CholU patients. Formalin-fixed, paraffin-embedded biopsies were stained to explore sweat leakage and tight junction protein expression. Dermcidin staining was not found outside the sweat glands. In the secretory coils of sweat glands, the distribution of claudin-3 and -10b as well as occludin was altered, but the zonula occludens-1 location was unchanged. In all, dermcidin and tight junction protein staining suggests an intact barrier with reduced sweat production capability in CholU patients. For future studies, an ex vivo skin model for quantification of sweat secretion was established, in which sweat secretion could be pharmacologically stimulated or blocked. This ex vivo model will be used to further investigate sweat gland function in CholU patients and decipher the underlying pathomechanism(s).
The present disclosure provides methods and materials related to MANP. In an aspect, the present disclosure provides methods of treating hypertension with metabolic syndrome in a patient in need thereof by administering MANP. In an aspect, the present disclosure provides methods comprising administering an MANP to a patient to reduce blood pressure (BP). In an aspect, the methods of the present disclosure are employed to treat a patient having a low baseline cGMP. In an aspect, the present disclosure provides methods of treatment using MANP to increase plasma cGMP, plasma ANP-like peptides, insulin sensitivity, or plasma NEFA. In an aspect, the present disclosure provides methods of treatment using MANP to decrease plasma glucose level.
Iatrogenic adrenal insufficiency (IAI) is the most common form of adrenal insufficiency in adult patients, although its overall exact prevalence remains unclear. IAI is associated with adverse clinical outcomes, including adrenal crisis, impaired quality of life and increased mortality; therefore, it is imperative that clinicians maintain a high index of suspicion in patients at risk of IAI to facilitate timely diagnosis and appropriate management. Herein, we review the major causes, clinical consequences, diagnosis and care of patients with IAI. The management of IAI, particularly glucocorticoid-induced (or tertiary) adrenal insufficiency, can be particularly challenging, and the provision of adequate glucocorticoid replacement must be balanced against minimizing the cardiometabolic effects of excess glucocorticoid exposure and optimizing recovery of the hypothalamic-pituitary-adrenal axis. We review current treatment strategies and their limitations and discuss developments in optimizing treatment of IAI. This comprehensive Review aims to aid clinicians in identifying who is at risk of IAI, how to approach screening of at-risk populations and how to treat patients with IAI, with a focus on emergency management and prevention of an adrenal crisis.
A method for imaging and three-dimensional modeling portions of the heart, particularly the left ventricular endocardial and epicardial surfaces, using imaging data. Preferably, a transesophageal ultrasound probe is inserted into an esophagus of a patient to provide multiple plane imaging data at end systole and end diastole during a cardiac cycle. The image planes are then traced along the boundaries of the epicardial and endocardial surfaces to produce sets of data points, which are further processed and expanded through interpolation. These data points are used for modeling the endocardial and epicardial surface at the end systole and end diastole extremes of the cardiac cycle. A center surface is constructed between an inner and outer surface of the modeled surfaces of the left ventricle and either an average template of tiled sections is mapped onto this center surface, or a mesh of triangular tiled sections representing the inner surface is projected on the center surface to define corresponding numbered tiled sections on the center surface. The tiled sections of the center surface are then projected onto the inner and outer surfaces, defining triangular prisms. By determining the volume of the triangular prisms and an average area for their ends, the range of movement, which is equal to the volume divided by the average area, is determined. Similarly, for changes in wall thickness between the endocardial and epicardial surfaces at end diastole and end systole, the thickening of the cardiac wall is determined.
The proposed trial comparing the two different meditation protocols is expected to have two phases: 0-month to 4.5-month period where we compare the Kundalini Yoga protocol with Relaxation Response meditation technique, both on the primary efficacy variable using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and some if not most of the secondary variables using The Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS), Clinical Global Impressions (CGI), Profile of Mood States (POMS), Beck Anxiety Inventory (Beck-A), Beck Depression Inventory (Beck-D), and SF-36 Health Status Questionnaire (SF36). Participants will go to the hospital once a week for a 1,5 hour meditation class.After 4.5-months, all patients will be evaluated and merged together into a single group. Patients will then receive 09 to 12 more months of the meditation protocol. The investigators are expecting to recruit 50 to 60 patients to start. Patients will be blinded to the content of the protocol in the other group at baseline and until one group shows greater efficacy on the primary efficacy variable. The intake physician will be blinded to the treatment groups of the patients.
BACKGROUND: The transition to menopause is a significant event affecting health, well-being, and quality of life. Menopause typically occurs between the ages of 44-57, accompanied by symptoms such as hot flashes, mood changes, and sleep disturbances. Being postmenopausal also increases the risk of cardiovascular disease, stroke, and osteoporosis. Despite its importance, menopause is under-researched and under-discussed, particularly concerning the impact of chronic psychosocial stress.
METHODS: A scoping review of qualitative, quantitative, and mixed methods research was conducted to map existing literature on the transition to menopause among populations experiencing chronic psychosocial stress in the United States. The review followed the PRISMA-ScR methodology, systematically searching literature in PubMed and SCOPUS databases using MeSH terms. Studies were included which focused on menopausal symptoms and psychosocial stressors. Data extraction and charting were performed using Covidence software.
RESULTS: Fifteen studies were included, highlighting relationships between socioeconomic status, intimate partner violence, childhood abuse, and racial disparities which influenced menopausal experiences. Lower- income, higher perceived stress, and negative attitudes towards menopause were associated with increased psychological and somatic symptoms and early onset of menopause (prior to age 45). African American women were found to experience earlier onset and more severe vasomotor symptoms compared to their White counterparts. Women veterans used hormone therapy more frequently than the general population, particularly those with mood or anxiety disorders. The review also identified a geographic bias, with most studies conducted in the Northeast, Midwest, and Western regions of the United States.
CONCLUSIONS: This review underscores the necessity of considering social, cultural, and environmental factors in understanding menopausal experiences and addressing health disparities. Future research should aim to include diverse populations and adopt longitudinal and qualitative study designs to capture the dynamic nature of menopausal experiences. Policies and interventions directed at improving the well-being of women experiencing menopause in the context of chronic psychosocial stress are warranted.
TRIAL REGISTRATION: N/A.
History and the 2009 H1N1 influenza pandemic suggest that both seasonal and pandemic influenza infections impart disproportionate morbidity and mortality among gravidas. The influenza vaccine represents a viable, preventive health intervention to mitigate disease burden for gravidas and their neonates. Despite the safety and efficacy of influenza vaccines, suboptimal maternal vaccination rates (13-24%) persist nationwide. Barriers to influenza vaccination during pregnancy include patient concerns about vaccine safety and unappreciated risk of influenza infection. Cellular phone text messaging has emerged as an innovative technology with advantages of ubiquity, rapid, confidential information transmission, and low cost. Text messaging may represent an effective way to educate pregnant women about their particular vulnerability to influenza infection and enhance influenza vaccine uptake. We propose a randomized, controlled clinical trial to assess whether text messaging to an outpatient obstetric population can improve maternal influenza vaccine uptake.
The invention provides a DNA nano composition, a preparation method and application thereof. The DNA nano composition consists of a triangular DNA paper folding structure, a nucleic acid drug miR155 and a nucleic acid aptamer GS24. miR155 and GS24 were loaded onto the triangular DNA origami structure by base-pairing. The prepared DNA nano composition can be used for the immunotherapy of glioblastoma. GS24 helps the nanomedicine cross the blood brain barrier by specifically binding to transferrin receptor overexpressed on the surface of cerebrovascular endothelial cells. Subsequently, the nano-drugs are taken up by tumor-associated microglia and macrophages, and the miR155 is released into the cytoplasm to play a role. miR155 promotes the production of pro-inflammatory cytokines and other mediators by down-regulating the expression of anti-inflammatory protein SOCS-1 in microglia and macrophages, ultimately resulting in reprogramming of tumor-associated microglia and macrophages from a pro-tumor M2 type to an anti-tumor M1 type.
The intervention group will receive a 4-week laughter yoga programme (8 sessions). This group also receives routine care provided by the special school as usual.
Ferroptosis is a novel form of programmed cell death that is iron-dependent and distinct from autophagy, apoptosis, and necroptosis. It is primarily characterised by a decrease in glutathione peroxidase 4 (GPX4) activity, or by the accumulation of lipid peroxidation and reactive oxygen species (ROS). Renal fibrosis is a common pathological change in the progression of various primary and secondary renal diseases to end-stage renal disease and poses a serious threat to human health with high morbidity and mortality. Multiple pathways contribute to the development of renal fibrosis, with ferroptosis playing a crucial role in renal fibrosis pathogenesis due to its involvement in the production of ROS. Ferroptosis is related to several signalling pathways, including System Xc-/GPX4, abnormal iron metabolism and lipid peroxidation. A number of studies have indicated that ferroptosis is closely involved in the process of renal fibrosis caused by various kidney diseases such as glomerulonephritis, renal ischaemia-reperfusion injury, diabetic nephropathy and renal calculus. Identifying the underlying molecular mechanisms that determine cell death would open up new insights to address a therapeutic strategy to renal fibrosis. The review aimed to browse and summarise the known mechanisms of ferroptosis that may be associated with biological reactions of renal fibrosis.
The invention discloses a cortex choerospondias proanthocyanidins and a preparation method and application thereof. The cortex choerospondias proanthocyanidins is extracted and purified from an effective part of cortex choerospondias. The invention discloses that cortex choerospondias contains high content of procyanidins. The plant extract prepared from cortex choerospondias by purification has antioxidant activity at a low concentration higher than that of Pycnogenol in the same concentration. Chemical composition analysis shows that the extract the contents of antioxidant components such as flavonoids, phenolic compounds and iconic flavanone-3-alcohol are higher than thos in Pycnogenol. The extract has the advantages of easily available raw materials, simple extraction process and low cost, and has a very broad market prospects and economic values.
The constitution of blood relies upon hematopoietic stem cells (HSCs), which stay in the bone marrow and differentiate to all lineages of peripheral blood cells. HSC transplantation is the only curative option currently available for sickle cell disease (SCD) patients either via allogeneic HSC transplantation or HSC-targeted gene therapy. Granulocyte-colony stimulating factor (G-CSF)- mobilized HSCs are frequently utilized in the adult setting of HSC transplantation because of the faster hematologic recovery as compared to bone marrow. As an autologous HSC source for gene therapy, bone marrow harvest has been generally employed since G-CSF has been prohibitive in SCD patients due to granulocyte stimulation and the associated reports of vaso-occlusive crises, multi-organ failure, and death. However, when bone marrow harvest is used, the amounts of collected cells are limited and anesthesia is required. In order to obtain HSCs in large numbers without anesthesia, patients will undergo mobilization followed by large volume apheresis. Plerixafor is an alternative treatment for mobilization without direct stimulation to granulocytes, and it is theoretically applicable for SCD patients. The primary endpoint of this study is to obtain sufficient amounts of HSCs collected from the peripheral blood in SCD patients after plerixafor mobilization with an acceptable safety profile. The harvested products will be stored as backup for patients undergoing gene therapy as well as allogeneic HSC transplantation.
A parallel group, cluster randomized controlled trial. The study population is adult participants of a cardiac rehabilitation programme in Norway with home Internet access and mobile phone, who in monthly clusters are randomized to the control or the intervention condition. Participants have access to a website with information regarding cardiac rehabilitation, an online discussion forum and an online activity calendar. Those randomized to the intervention condition, receive in addition tailored content based on models of health behaviour, through the website and mobile text messages. The objective is to assess the effect of the intervention on maintenance of self-management behaviours after the rehabilitation stay. Main outcome is the level of physical activity one month, three months and one year after the end of the cardiac rehabilitation programme. The randomization of clusters is based on a true random number online service, and participants, investigators and outcome assessor are blinded to the condition of the clusters.

The study suggests a theory-based intervention that combines models of health behaviour in an innovative way, in order to tailor the delivered content. The users have been actively involved in its design, and because of the use of Open-Source software, the intervention can easily and at low-cost be reproduced and expanded by others. Challenges are the recruitment in the elderly population and the possible underrepresentation of women in the study sample
Wraparound is a 12-month intervention including a family-centered discovery process to identify values, needs, and strengths to help the family be successful in reaching family functioning and parental recovery goals; weekly or twice weekly family meetings with the Wraparound coordinator; intensive care coordination among systems and providers (substance use disorder, mental health, schools, pediatrics, homeless shelters, etc.); and bi-monthly family-centered team meetings (including the family's natural and professional supports) to discuss strategies, progress and continued needs. Wraparound coordinators (2) work with up to 10 families at a time and receive extensive training (including observation) and supervision by expert trainers at University of New Hampshire.
Participants randomized to the intervention group will receive six premade egg-containing breakfast meals per week in the form of a 3-day rotating menu. Each meal contains 2 eggs to provide 12 eggs per week for a duration of 12 weeks.
Tumor-associated macrophages (TAM) have been shown to have important roles in the malignant progression of various cancers. However, macrophages also possess intrinsic tumoricidal activity and can promote the activity of cytotoxic lymphocytes, but they rapidly adopt an alternative phenotype within tumors, associated with immune-suppression and trophic functions that support tumor growth. The mechanisms that promote TAM polarization in the tumor-microenvironment remain poorly understood, these mechanisms may represent important therapeutic targets to block the tumor-promoting functions of TAM and restore their anti-tumor potential. Here the inventors have characterized TAM in a mouse model of metastatic ovarian cancer. They show that ovarian cancer cells promote membrane-cholesterol efflux and the depletion of lipid rafts from macrophages. Increased cholesterol efflux promoted IL-4 mediated reprogramming while inhibiting IFN-induced gene expression. These studies reveal an unexpected role for tumor-induced membrane-cholesterol efflux in driving the IL-4 signaling and the tumor-promoting functions of TAM, while rendering them refractory to pro-inflammatory stimuli. Thus, preventing cholesterol efflux in TAM could represent a novel therapeutic strategy to block pro-tumor functions and restore anti-tumor immunity.
IN VITRO method to calculate the dosage of the drug adalimumab or biosimilars to be administered for the treatment of inflammatory bowel diseases. The invention relates to an in vitro method for calculating the appropriate dosage and dosage range of adalimumab or its biosimilars to be administered to a patient with inflammatory bowel disease. Said method comprises the application of a mathematical formula based on three individual patient factors: (i) the body mass index (BMI), (ii) the amount of fecal calprotectin and (iii) the presence or absence of anti-adalimumab antibodies. . This method allows the dosage to be adapted to the patient's situation, increasing the success of therapy by achieving therapeutic serum concentrations of the drug. The invention also proposes a dosage schedule for adalimumab or its biosimilars, preferably to be administered during the maintenance phase of the treatment, which allows reaching plasma therapeutic drug concentrations. (Machine-translation by Google Translate, not legally binding)
The patients with osteonecrosis of femoral head undergo total hip replacement. Femoral head specimens will be collected and ex vivo specimens numbered. Using RT-PCR, Runx2, BMP-2, BMP-7 and osteoprotegerin, mRNA expression levels will be quantitatively analyzed. Osteocalcin immunoreactivity will be detected using immunohistochemical staining.
<P>PROBLEM TO BE SOLVED: To provide hair follicle stem cells expressing nestin and the use thereof.  <P>SOLUTION: Hair follicle stem cells are separated from mammals by separating nestin expressing cells. The hair follicle stem cells have a pluripotent ability to differentiate to the other cell types containing neuron, astroglia, smooth muscle fiber, keratin generation cells and fat cells, and become the source of supply of adult stem cells for the self or interspecies stem cell treatment. The stem cells are systemically transplantable to mammals, or are directly transplantable to internal organs. Moreover, after making the stem cells further differentiate in vitro, it is possible to transplant the cells to mammals systemically or directly.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Cross-cultural differences in the association between neuropsychiatric symptoms and Alzheimer's disease (AD) biomarkers are not well understood. This study aimed to (1) compare depressive symptoms and frequency of reported apathy across diagnostic groups of participants with normal cognition (CN), mild cognitive impairment (MCI), and dementia, as well as ethnic groups of Hispanic Americans (HA) and European Americans (EA); (2) evaluate the relationship between depression and apathy with Aβ deposition and brain atrophy. Statistical analyses included ANCOVAs, chi-squared, nonparametric tests, correlations, and logistic regressions. Higher scores on the Geriatric Depression Scale (GDS-15) were reported in the MCI and dementia cohorts, while older age corresponded with lower GDS-15 scores. The frequency of apathy differed across diagnoses within each ethnicity, but not when comparing ethnic groups. Reduced volume in the rostral anterior cingulate cortex (ACC) significantly correlated with and predicted apathy for the total sample after applying false discovery rate corrections (FDR), controlling for covariates. The EA group separately demonstrated a significant negative relationship between apathy and superior frontal volume, while for HA, there was a relationship between rostral ACC volume and apathy. Apathy corresponded with higher Aβ levels for the total sample and for the CN and HA groups.
Each participant will stay in the calorimeter (\~24 hrs) on 2 different occasions. During the first visit, the participant will partake in an unguided exercise session.