anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Method for producing and purifying protein antigens (Ag) of Mycobacterium bovis BCG (esp. the strain 1173 P2) in Sauton medium deficient in zinc, includes the step of adding, during prepn. of the medium, a quantity of zinc equal to about 10% of the amt. of zinc normally added, i.e. 0.1425 mg of ZnSO4.7H2O. 7H2O per l. After fermentation, the cell-free medium is recovered after filtration and Ag purified from the filtrate. Also new are mono- or poly-clonal antibodies (Ab) against Ag.
<P>PROBLEM TO BE SOLVED: To provide a system for automatically, sterilely and safely refining and retrieving a glycoprotein such as fibronectin from plasma in high yield.  <P>SOLUTION: This system has the following construction: A plasma receptacle 45, a receptacle 44 filled with a 1st buffer solution, a receptacle 43 filled with an eluate, and a receptacle 42 filled with a 2nd buffer solution are unified into a solution cartridge 4. The solution cartridge 4 is mounted on a corresponding mount 21 of a cartridge mount 2 provided in the system body 1. A column cartridge 5 is mounted on a corresponding mount 22, and a flow path cartridge 6 is mounted on a corresponding mount 23. In this system, a control unit C works as follows: Based on a program data stored in advance, the objective glycoprotein is automatically refined by controlling an injection needle insertion driving means, a tube-pressing type liquid feeder and a tube-pressing type electric valve.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
A system comprising a user interface and a controller operating to receive an input at a control interface. The system generates a control signal associated with the control interface. The system operates one or more filters to select a first set of food items from a proximal food distributor database and a menu rules control. The system generates a menu generation control signal utilizing the first set of food items selected and the menu rules control. The system sends the menu generation control signal to a menu generator and in response receive a menu control signal from the menu generator, the menu control signal associated with a second set of food items in the proximal food distributor database, wherein the second set of food items is a subset of the first set of food items. The system alters the machine display based on the menu control signal.
BACKGROUND: In this study, we aimed to establish a stable and standardized animal model of peritoneal adhesions.
METHODS: Forty-eight male Sprague-Dawley rats were randomly divided (n = 12 each) into blank control, classic cecum sidewall, ischemic button, and cecum-sidewall suture groups. The modified American Fertility Society adhesion score was used on postoperative day 7 to evaluate adhesions. Sixty male Sprague-Dawley rats were used to dynamically observe the adhesion characteristics of cecum-sidewall ischemic injury suture model at different time points (n = 60, randomly divided into groups a-e with 12 rats each). The modified American Fertility Society and Zühlke histologic scoring systems, hematoxylin-eosin staining, Masson staining, and computed tomography of the abdomen were used to evaluate adhesions on postoperative days 1, 3, 5, 7, and 14.
RESULTS: No peritoneal adhesions were observed in the blank control group on postoperative day 7. In the classic cecum sidewall group, 8 rats had inconsistent adhesions, which had a modified American Fertility Society adhesion score of 2.25 ± 1.96. All rats in the ischemic button and cecum-sidewall suture groups developed significant adhesions with modified American Fertility Society scores of 3.08 ± 1.31 and 4.67 ± 0.78, respectively. When the modified American Fertility Society score was used, statistically significant differences were observed between the classic cecum sidewall groups and cecum-sidewall suture groups and between the ischemic button groups and cecum-sidewall suture groups. All animals in groups a-e developed adhesions; adhesion scores increased gradually with time.
CONCLUSIONS: The cecum-sidewall ischemic injury suture model is a stable and standardized animal model of peritoneal adhesions.
PROBLEM TO BE SOLVED: To obtain the subject preparation producible by a simple method for production and excellent in feeling of administration even if the amount of an additive such as a gelling agent is small by including a cation exchange resin and the gelling agent. SOLUTION: This preparation is obtained by including (A) a cation exchange resin having preferably 5-500 μm average particle diameter (e.g. calcium polystyrenesulfonate or sodium polystyrenesulfonate) and (B) a gelling agent [e.g. carmellose sodium (CMC-Na), hydroxypropyl methyl cellulose(HPMC) or methyl cellulose(MC)] and, as necessary, (C) a binder [e.g. dextrin, crystalline cellulose, hydroxypropyl cellulose(HPC) or ethyl cellulose(EC)]. In the above preparation the amounts of the contained ingredients are preferably 0.5-20 wt.% of the ingredient B and 0.1-20 wt.% of the ingredient C.
After signing the informed consent, they are screened to meet the inclusion criteria. After receiving the standard dose of adebrelimab combined with DOS regimen for 3 courses of treatment before surgery, and within 3-6 weeks after the completion of the third administration, preoperative imaging examination is used to evaluate the efficacy of new adjuvant treatment and the possibility of radical D2 resection, The patient underwent radical surgical treatment for gastric cancer and observed pCR.
Patients receive autologous HER2(EQ)BBzeta/CD19t+ Tcm cells via intratumoral/intracavitary catheter over 5 minutes weekly for 3 weeks. Beginning as early as 1 week later, patients may receive additional T cell infusions as long as patients remain eligible and there is product available. Patients who progress on intracavitary or intratumoral administration may move to alternative delivery routes for the optional infusions.
For patients after cardiac surgery, antiplatelet drugs or anticoagulants are usually used for preventing thrombosis. Use of those drugs is associated with increased risk of bleeding. Any invasive procedures may put those patients at additional risk of bleeding. Ultrasound (US) has become widely accepted to guide safe and accurate central venous catheterization. Ultrasound-guided axillary vein catheterization can be performed via the oblique-axis and long-axis approaches of the axillary vein. The aim of our study is to compare the first puncture success rate and safety between the two approaches of ultrasound-guided axillary vein catheterization in cardiac surgical patients with high bleeding risk
A computer-implemented method of determining pathogenicity of a combination of double-or oligogenic variations associated with a disease is described. The method first includes defining a set of variations for which pathogenicity must be determined. Such variation refers to a mutation in one or both alleles of a corresponding gene in at least two genes, wherein each gene is associated with two corresponding alleles. The method then comprises the step of determining what is likely to happen with respect to the presence or absence of the aforementioned variations in the alleles of the at least two genes under consideration. Each occurrence is associated with a respective combination in which each variation is present in a respective set of all possible sets of alleles for all genes under consideration, or in all alleles for all genes under consideration. For each defined case, i.e., for each combination and each gene, the method then includes calculating a pathogenicity index or score that is adapted to estimate how much the corresponding mutation(s) alters the function of the corresponding gene. The method further comprises the steps of: the patient's phenotypic trait is described by standardized phenotypic terms, i.e. standardized information suitable for describing phenotypic abnormalities found in the patient, and input information for pathogenicity determination is calculated or prepared. This information includes the following four types of features: gene-phenotype association characteristics, calculated separately for each gene considered, and adapted to measure how much overlap the above-mentioned phenotypic trait of a patient overlaps with a phenotype known to be associated with a single gene; a dual-or oligogenic feature calculated for each of the above combinations of genes and adapted to capture interactions between the genes forming each combination; a priori attribute characteristics of the genes, calculated for each of the above genes considered; variation-related features are calculated for each gene under consideration based on the above-described pathogenicity index or score associated with all combinations under consideration. The method further comprises providing said input information for pathogenicity determination to at least one trained algorithm and processing said input information for pathogenicity determination by said at least one trained algorithm. The trained algorithms are algorithms trained by artificial intelligence and/or machine learning techniques. The algorithm is trained in a preliminary training step based on a training dataset of known cases, the above-described input information calculated for each known case is provided to the algorithm to be trained, and the algorithm is trained based on knowledge of the pathogenicity/benign nature of the corresponding known case. Finally, the method comprises the step of obtaining output information from the trained algorithm, the output information being indicative of the pathogenicity of each combination of the considered variations or mutations.
Although the molecular mechanisms underlying congenital heart disease (CHD) remain poorly understood, recent advances in genetic analysis have facilitated the exploration of causative genes for CHD. We reported that the pathogenic variant c.1617del of TMEM260, which encodes a transmembrane protein, is highly associated with CHD, specifically persistent truncus arteriosus (PTA), the most severe cardiac outflow tract (OFT) defect. Using whole-exome sequencing, the c.1617del variant was identified in two siblings with PTA in a Japanese family and in three of the 26 DNAs obtained from Japanese individuals with PTA. The c.1617del of TMEM260 has been found only in East Asians, especially Japanese and Korean populations, and the frequency of this variant in PTA is estimated to be next to that of the 22q11.2 deletion, the most well-known genetic cause of PTA. Phenotype of patients with c.1617del appears to be predominantly in the heart, although TMEM260 is responsible for structural heart defects and renal anomalies syndrome (SHDRA). The mouse TMEM260 variant (p.W535Cfs*56), synonymous with the human variant (p.W539Cfs*9), exhibited truncation and downregulation by western blotting, and aggregation by immunocytochemistry. In situ hybridization demonstrated that Tmem260 is expressed ubiquitously during embryogenesis, including in the development of cardiac OFT implicated in PTA. This expression may be regulated by a ~ 0.8 kb genomic region in intron 3 of Tmem260 that includes multiple highly conserved binding sites for essential cardiac transcription factors, thus revealing that the c.1617del variant of TMEM260 is the major single-gene variant responsible for PTA in the Japanese population.
OBJECTIVES: In congenital hemolytic anemias (CHA), it is not always possible to determine the specific diagnosis by evaluating clinical findings and conventional laboratory tests. The aim of this study is to evaluate the utility of next-generation sequencing (NGS) and clinical-exome-based copy number variant (CNV) analysis in patients with CHA.
METHODS: One hundred and forty-three CHA cases from 115 unrelated families referred for molecular analysis were enrolled in the study. Molecular analysis was performed using two different clinical exome panels in 130 patients, and whole-exome sequencing in nine patients. Exome-based CNV calling was incorporated into the traditional single-nucleotide variant and small insertion/deletion analysis pipeline for NGS data in 92 cases. In four patients from the same family, the PK Gypsy variant was investigated using long-range polymerase chain reaction.
RESULTS: Molecular diagnosis was established in 86% of the study group. The most frequently mutated genes were SPTB (31.7%) and PKLR (28.5%). CNV analysis of 92 cases revealed that three patients had different sizes of large deletions in the SPTB and six patients had a deletion in the PKLR.
CONCLUSIONS: In this study, NGS provided a high molecular diagnostic rate in cases with rare CHA. Analysis of the CNVs contributed to the diagnostic success.
There are many mindfulness-based interventions protocol that can be implemented and practice by healthcare organization. In the current study, the intervention protocol the investigators will use is based on Smiths version of mindfulness meditation (Smith, 2005). This version is compromised of several components includes being mindful of breathing, thought, sounds, taste, body scan, and sitting. The initial educational session by power point presentation will be given to the participant to explain the intervention rationale and procedure of mindfulness in daily life. In addition to giving opportunity for the participant to ask questions during the educational session.
BACKGROUND: Perioperative neurocognitive disorder and postoperative depressive symptoms are significant complications after surgery. Studies have indicated that esketamine possesses neuroprotective and antidepressant qualities.
METHODS: This trial included 209 patients aged 60 to 86 years undergoing tumor resection who received esketamine (Group E) or not (Group C) during and after surgery. In group E, patients were given an intravenous dose of 0.5 mg/kg of esketamine 10 minutes after induction of general anaesthesia. In addition, esketamine (2 mg/kg) in combination with sufentanil was used for PCIA during 48 hours postoperatively. On the other hand, saline was used as a substitute for esketamine in group C. Cognitive function was evaluated using neuropsychological tests and telephone interview for cognitive status-modified, and symptoms of depression were assessed using Hamilton Depression Rating Scale 17.
RESULTS: Compared to Group C, patients in Group E exhibited lower rates of depressive symptoms at 3, 7, and 90 days post-surgery (53.9% vs 67.7%, 26.3% vs 47.9%, and 13.3% vs 28.4%). Group E also showed decreased time for Trail Making Test on days 7 and 90. However, there were no significant differences in the incidence of delirium 1 to 5 days post-surgery or cognitive impairment 90 days post-surgery between the 2 groups (12.1% vs 10.9% and 8.4% vs 9.7%).
CONCLUSIONS: Intraoperative low-dose esketamine and postoperative low-dose esketamine combined with sufentanil for patient-controlled intravenous analgesia has been shown to improve postoperative analgesia, alleviate postoperative depressive symptoms, and aid in the recovery of social executive ability. However, this approach did not reduce the incidence of postoperative delirium or postoperative cognitive dysfunction.
Subjects will be enrolled in Cohort 3b only if required for further investigation. Subjects will receive GSK3039294 for 21 consecutive days and more than one dose level or regimen may be investigated, for example on the first 10 days the dose may be administered thrice daily, and on the last 11 days may be administered twice daily.
During menopause, up to 90% of women will experience symptoms of anxiety, such as nervousness, irritability, fatigue, muscle aches, depression, and low libido. Concern over the safety and effectiveness of hormone replacement therapy for relieving these symptoms has caused many women to seek alternative medical treatments. Data suggest that black cohosh has a direct effect on the neurotransmitters and receptors involved in anxiety. This study will determine whether black cohosh can effectively treat anxiety symptoms in menopausal women.

This study will last 12 weeks. Participants will be randomly assigned to receive either black cohosh or placebo daily for the duration of the study. Self-report scales will be used to assess participants' anxiety symptoms and quality of life at the beginning and end of the study.
Invasive ExPEC disease (IED) is defined as an acute illness consistent with bacterial infection that is microbiologically confirmed by the isolation and identification of E. coli from blood or other normally sterile body sites, or by the isolation and identification of E. coli from urine in a patient with signs and symptoms of invasive disease and no other identifiable source of infection. Adults aged 60 years or older have an increased risk of developing IED. To date, there is no vaccine available to prevent IED. ExPEC10V is a 10 valent vaccine candidate in development by Janssen R\&D for the prevention of IED in adults aged 60 years and older. A Phase 3 clinical study is planned to investigate the efficacy and safety of this vaccine. To obtain insight in the feasibility and design of the Phase 3 study, a pilot study is required.

This pilot study is a prospective, multicenter, observational study conducted in a maximum of eight countries in Europe, North-America and Asia. Participant recruitment will be done in primary care. In each participating country a local primary care network encompassing approximately 40,000 persons and a local hospital, where patients are referred to in case of a suspicion of IED, will participate in this study.

Database screening at the primary care centers will be performed to identify and invite potential eligible study participants. Upon consent, each study participant will be followed for a period of maximum 12 months after enrollment in the study. At baseline, demographic data and medical history data will be collected. During the follow-up period, any referral of study participants to a hospital for any reason including IED will be collected. IED identification and Medical Resource Utilization (MRU) during the follow-up period will be performed by regular telephone calls with all study participants. At the end of the study, the primary care files will also be checked for MRU. If a participant is diagnosed with IED and admitted to the hospital, the following data will be collected: medical history and treatment received 90 days prior to the IED, clinical and laboratory data, data on the treatment and outcome of IED and data on MRU related to IED. Data will be collected on Day 1 of IED diagnosis (signs/ symptoms) and Day 28 after IED diagnosis.
<P>PROBLEM TO BE SOLVED: To provide a method for preserving microorganisms and materials originating from an animal.  <P>SOLUTION: This method for preserving the microorganisms or the materials originating from the animal is provided by placing them under an electrostatic field atmosphere for preservation. The electrostatic field atmosphere is formed by impressing 100-5,000 V alternate or direct electric voltage on electrodes. The preserving temperature under the electrostatic field atmosphere is -20 to 40°C, and it is possible to preserve the microorganisms or materials originated from the animal including human without freezing at -12 to -1°C at which temperature such organisms or materials can be frozen unless under the electrostatic field atmosphere. The method for preservation is useful for the preservation of organs, internal organs, tissues, cells, blood, plasma, serum, a blood preparation, a purified protein, a recombinant protein, cultured cells, cultured tissues, etc., and can be utilized especially in a transplanting field, blood transfusion field, regenerative medicinal field, basic experimental field, genetic therapeutic field, clinical test field, pharmaceutical field, diagnostic field, etc.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The use of CGMS (Sensor, receiver, transmitter) plus the uploading of results to the Internet-based software utility of CareLink Personal and generating reports that can be viewed and used at the patient's own preference. This group will send the uploaded data and receive feedback from their endocrinologist every 2 weeks.
Though considered a best practice, there is substantial variation in how integrated behavioral health (IBH) services are structured. This study examined the impact of IBH structure on health outcomes among individuals with serious mental illness (SMI) and chronic disease receiving care in community health centers (CHCs). Data from the ADVANCE network identified 8,548 individuals with co-occurring SMI diabetes and 16,600 with an SMI and hypertension. Logistic regression tested whether IBH type impacted disease specific health outcomes among these populations. Among those with diabetes or hypertension, colocated care was associated with better health outcomes related to HbA1c, blood pressure control, and BMI compared to less coordinated and unintegrated care, though there was significant variation in this relationship across SMI diagnoses. Results reflect that colocation of primary care and behavioral health may improve outcomes for individuals with bipolar disorder or major depression and chronic disease, but that CHC-based integrated care may not be optimized for individuals with schizophrenia.
Few previous review articles have focused on the associations between inadequate daily water intake (LOW) or urinary biomarkers of dehydration (UD; low urine volume or high urine osmolality) and multiple diseases. Accordingly, we conducted manual online searches (47 key words) of the PubMed, Embase, and Google Scholar databases with these inclusion criteria: English language, full-text, peer reviewed, no restriction on research design, and three publications minimum. Initially, 3,903 articles were identified based on their titles and abstracts. Evaluations of full length .pdf versions identified 96 studies that were acceptable for inclusion. We concluded that the evidence is insufficient or conflicting for seven disorders or diseases (i.e. suggesting the need for additional clarifying research) and it is lacking for all-cause mortality. Differential characterizations among women and men have been reported in the results of nine studies involving five diseases. Finally, the evidence for associations of LOW or UD is strong for both kidney stones and type 2 diabetes with hyperglycemia. This suggests that great public health value (i.e. reduced disease risk) may result from increased daily water intake-a simple and cost-effective dietary modification.
1450424 Increasing yields of crops HERSHEY FOODS CORP 2 Oct 1973 [13 Nov 1972 18 Sept 1973] 46001/73 Heading C1B The yield of a wide range of crops may be increased by treating a plant (defined) with active spores of Bacillus uniflagellatus (ATCC No. 15,134) which are defined as those spores which, after germination and growth in root exudate, release an antibiotic substance which is that produced by the procedure described in U.S.A. Specification No. 3,617,448 and which may be assayed by the method disclosed therein. The spores may be commingled with the plant seeds before planting and may be coated with the antibiotic derived from Bacillus uniflagellatus (ATCC No. 15,134) or the leaves of the plant may be sprayed with the active spores, which may be washed into the soil surrounding the plant. The spores may be applied in the form of a dried mixture with the culture medium in which the antibiotic material has been produced, or the spores may be dispersed on a powdered carrier.
Group 5, will consist of 8 healthy subjects enrolled to match the sex-, age-, and weight of the patients with mild, moderate, and severe renal impairment and patients with ESRD enrolled in the study. Healthy subjects will be administered a single 400 mg dose of pacritinib.