anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Stroke was a major global public health challenge, and its prognosis was remarkably associated with inflammation levels and nutritional status. The advanced lung cancer inflammation index (ALI) was a comprehensive indicator that combined inflammation and nutritional status. Currently, the relationship between ALI and the prognosis of stroke patients was not yet known. The purpose of the current study was to estimate their relationship.
METHODS: Cohort data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were collected. The association between ALI and all-cause and cardiovascular disease (CVD) mortality in stroke patients was estimated using a multivariable adjusted Cox model. Their non-linear relationship was analyzed by restricted cubic spline analysis. Sensitivity analysis was constructed through stratified analysis and interaction analysis.
RESULTS: 1,440 stroke patients were included in this study. An elevated ALI was significantly related to a reduced risk of all-cause mortality in stroke patients but not related to CVD mortality. A reverse J-shaped non-linear association between ALI and all-cause mortality in stroke patients, with an inflection point at 83.76 (the lowest of the mortality risk). On the left side of the inflection point, for each 10 U increase in ALI, there was a 16% reduction in the risk of all-cause mortality. However, on the right side, the risk increased by 6%. There was no remarkable interaction between stratified variables and ALI.
CONCLUSION: This was the first study on the relationship between ALI and all-cause and CVD mortality in stroke patients. Elevated ALI was closely associated with a reduced risk of all-cause mortality. A reverse J-shaped non-linear relationship existed between the two, with an inflection point at 83.76. These findings implied that controlling the ALI of stroke patients within an appropriate range was crucial for their prognosis (such as weight management, albumin supplementation, anti-inflammatory treatment). The dynamic variation in ALI was also advantageous for clinicians in establishing personalized ALI criteria to maximize the long-term survival of stroke patients.
Participants will be administered reference product (placebo to match Paracetamol 665mg sustained release tablets). Two tablets will be taken orally once with 200 mL of water.
Interventions include the following: All participants will have a loading dose of Ticagrelor (Brilinta) 180 mg administered in the office at the time of enrollment. Thereafter, for 28 days, Ticagrelor 90 mg tablet will be taken once in the morning and once in the evening, as close to 12 hours apart as possible. Each day, the subject will receive a text message reminder to login to the website, to record her/his headache activity.
Residual neuromuscular blockade during the immediate postoperative period is an important patient safety issue. Although used to facilitate the technical performance of surgery, clinical studies have associated neuromuscular blockade (NMB) with increased incidence of postoperative respiratory complications. This effect is likely mediated by residual neuromuscular blockade interfering with airway tone and respiratory effort, leading to postoperative pneumonia, atelectasis or aspiration. However, the vast majority of these studies have involved non-cardiac patient populations, yet patients undergoing cardiac surgery are even more susceptible to the detrimental effects of residual neuromuscular blockade for a number of reasons. Despite widespread utilization of paralysis during cardiac surgery, very little is known about residual neuromuscular blockade in patients following cardiac surgery. Previously published clinical studies date from over a decade ago or are based on retrospective databases from non-cardiac surgery patients, precluding generalizable conclusions. Given the substantial role of neuromuscular blockade in the traditional management of cardiac surgical patients, prospective data is needed to determine the veracity of this association as well as the surgical tolerability of protocols that minimize intraoperative paralysis. The investigators will conduct a prospective, randomized trial to assess impact of neuromuscular blockade on early (\<72 hours post-ICU admission) postoperative respiratory complications.
[PROBLEMS] To provide a denture stabilizer that without feeling of unpleasant sweet, enables fitting of a denture in the oral cavity. [MEANS FOR SOLVING PROBLEMS] There is provided a denture stabilizer comprising water, ethanol and 11 to 25% of cellulose derivative wherein the cellulose derivative exhibits a 2% viscosity at 25°C of 30 to 45 mPa s. Examples of the cellulose derivatives include water-soluble cellulose ethers, such as methylcellulose, ethylcellulose, hydroxylated alkylcelluloses (hydroxypropylmethylcellulose, hydroxyethylcellulose, etc.), carboxymethylcellulose, alkali metal carboxymethylcelluloses (sodium carboxymethylcellulose, potassium carboxymethylcellulose, etc.) and alkali metal cellulose sulfate salts. Among them, hydroxylated alkylcelluloses, carboxymethylcellulose and alkali metal carboxymethylcelluloses are preferred. Sodium carboxymethylcellulose is still preferred.
Participants will receive baseline testing to confirm a diagnosis of Parkinsonism and to determine eligibility in the research study. Half of the participants in this study will be in a group that will receive the study drug (rasagiline), and half will be in a group that will receive a placebo. A placebo is a pill that is made to look like the study drug, but it does not contain any active ingredients. A computer algorithm will randomly decide group assignment (like the flip of a coin). The study drug will be provided at the end of the first visit. The participants will not know which study drug is received, placebo or rasagiline.

During the research study the following test may occur: (1) questionnaires about quality of life and depression; (2) tests to measure strength and motor function; (3) tests to measure cognition; (4) orientation session to learn a precision gripping task; (5) functional MRI scan of the brain; (6) structural MRI scan of the brain.
Managing burn scars in children presents significant challenges. This study investigates effective treatment methods for burn scars, focusing on efficacy, safety, standard protocols and tolerability. Major databases such as PubMed, Scopus and Web of Science were thoroughly searched up to August 2024, emphasizing procedural treatments for burn scars in children. Key data collected included participant demographics, sample sizes, intervention methods, follow-up protocols, treatment effectiveness and reported adverse events. A total of 256 children were assessed, with all procedural treatments yielding satisfactory outcomes. Among the various methods, trapeze-flap plasty and percutaneous collagen induction showed improvements in all patients. In the laser treatment group, which included 161 children, the Vancouver Scar Scale (VSS) score reduction ranged from 55.55% to 76.31%, with outcomes rated as good (24.61%) to excellent (60%). Laser treatment using local anaesthesia proved to be well tolerated by children. Our findings indicate that various methods-including trapeze-flap plasty, percutaneous collagen induction, phototherapy and fractional CO2 laser-demonstrate a relatively good response and an acceptable safety profile. Notably, light-based therapies/lasers may serve as safe, effective and tolerable options for scar treatment in this age group, often eliminating the need for general anaesthesia.
The invention discloses a sciatica treatment Yao People medicine plaster. The plaster comprises, by weight, 80-120 parts of root or total plant of Piper boehmeriaefolium Wall. var. tonkinense C. DC, 80-120 parts of whole plant of Cissus hastata (Miq.) Planch, 40-60 parts of Asian Toddalia, 80-120 parts of Nux Vomica, 70-90 parts of stem and branch of Uncaria rhynchonphylla(Miq.)Miq.ex Havil., 70-90 parts of seed of Croton tiglium L., 70-90 parts of whole plant of Plumbago zeylanica L., 70-90 parts of Torricellia angulata Oliv.var.intermedia(Harms) HuT.inetrmedia, 4-6 parts of Boswellia carteri and 4-6 parts of myrrh. The invention also discloses a production method of the sciatica treatment Yao People medicine plaster. The plaster capable of dispelling wind and cold, eliminating dampness and dredging collaterals is produced through selecting appropriate Yao People medicines and an appropriate ratio, and has the advantages of fast effect, short treatment course and high cure rate.
Due to the typical peritoneal spread of the disease, together with cytoreductive surgery and adjuvant platinum-based chemotherapy, the role of hyperthermic intraperitoneal chemotherapy (HIPEC) is gainig more interest in advanced ovarian cancer (AOC) treatment. Indeed, the addition of hyperthemia seems to enhance the cytotoxic effect of chemotherapy directly delivered on peritoneal surface. So far, data on HIPEC administration during the primary debulking surgery (PDS) have been controversial. Indeed, despite flaws and biases, a survival advantage in a subgroup analysis of a prospective randomized trial of PDS+HIPEC treated patients was not demonstrated, whilst positive results are coming from a large retrospective cohort of patients treated with HIPEC after upfront surgery. In this setting, larger prospective data from an ongoing trial are expected by 2026. Contrariously, the addition of HIPEC with cisplatin 100mg/m2 at the time of interval debulking surgery (IDS) has shown to prolong both progression-free and overall survival by prospective randomized data, despite few controversies on the methodology and the results of this trial arose among the experts. So far, available high quality data on HIPEC treatment after surgery for disease recurrence failed to demonstrate a survival benefit in this group of patients, however few trials are ongoing and results are awaited. With this article, we aim to discuss the main findings of available evidence and the objectives of ongoing trials on the addition of HIPEC to various timing of cytoreductive surgery in AOC, also in view of the development of precision medicine and targeted therapies in AOC treatment.
NEW MATERIAL:A compound of formula I (R<1>-R<3> are H, halogen, OH which may be protected, nitro, carboxyl, lower alkyloxy or lower acyloxy; R<4> is H, -CH=CH-CH3; n is 0 or 1) and a salt thereof. EXAMPLE:2-Hydroxy-3,5-dibromophenylbutenone. USE:A drug. An effective component for delayed allergy remedies. The usage thereof is 10mg-5g/day as the effective component, when the drug is administered as an ointment. The ointment is suitably applied to an affected portion over one-several times. PREPARATION:The compound of formula I is obtained by reacting a substituted benzaldehyde of formula II with acetone of formula III in the presence of a basic catalyst such as NaOH at 0-100 deg.C for 0.5-48hr in excess acetone or an inert solvent as a reaction solvent.
Compounds, methods, compositions, uses and kits that allow for the treatment of cancer are disclosed. In some embodiments, the compounds are used to treat a disease or disorder. The compounds can treat cancer by targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, lymphoma, liver cancer, endometrial cancer, leukemia, or multiple myeloma. Compounds, methods, compositions, uses and kits useful in regenerative medicine are disclosed. In this disclosureThe compounds used have the formulae (0) and (I).
PURPOSE:To test the drug sensitivity of cancer cells by bringing the cells contg. the cancer cells into reaction with antihuman fibroblast antibodies and complement and subjecting the same to cell culture together with a drug. CONSTITUTION:The drug sensitivity of the cancer cells is tested without being affected by the fibroblast or macrophage by bringing the cells contg. the cancer cells into reaction with the antihuman fibroblast antibodies or antihuman macrophage antibodies and complement. The bactericide having an effect is determined by culturing the desired bacteria in media contg. various bactericides and investigating the presence or absence of colony formation. As a result, the bactericide contained in the culture liquid in which colonies are not formed is used as the sensitive drug for the bacteria. A liquid monolayer culture method with which the culture is relatively easy is preferably adopted at this time.
At each well-child check from 2- to 24-months, a trained bilingual facilitator from the CommUnityCare Centering Parenting program will present curriculum in person during 2-hour visits in a room with 3-8 mother-baby pairs per group. During each session, each mother-baby pair will be pulled out to a private medical room for a brief individual well child appointment with the pediatrician. During this appointment, infant measurements, physical exam, and discussion of unique concerns will take place before the pair returns to the session. There are 8 scheduled well child checks by the age of two, where regular parenting topics will be covered (i.e. discipline, safety, co-parenting, sibling relationships, childcare, development). Each Centering session is expected to last approximately 2 hours, for a total commitment of approximately 16 hours across 8 group sessions over the course of 22 months for each participant. Total time of enrollment should be approximately 22-24 months.
Hair treatment compositions containing about 0.1 to about 8 wt. % of xylan or derivatives thereof; about 0.2 to about 23 wt. % of gluconic acid; about 2 to about 45 wt. % of sorbitol; and water, wherein all percentages by weight are based on the total weight of the cosmetic composition. The weight fraction of the total amount of xylan or derivatives thereof to the total amount of gluconic acid is greater than 0.2 to less than 1. Example hair treatment compositions may form a film of xylan or derivatives thereof and gluconic acid on an individual's hair after the hair treatment composition has been rinsed from the hair. Methods for producing and using such hair treatment compositions are also provided.
Coating contains (i) a mixt. of cellulose ether and saccharose in ratio 90:10-40-60 as binder and (ii) conventional fillers and pigments, i n (i):(ii) ratio of 1:1-1:3. The coating protects the tablets and pellets against air, light moisture, loss of taste and crumbling during handling, and gives them a characteristic colour. Tablets require fewer coatings so the coating is quick Toxic and inflammable solvents are not used and there is no need to vapourise the solvent (water. The coating gives especial protection from air moisture. The cellulose ether is esp. methyl hydroxypropyl cellulose or methyl hydroxyethyl cellulose, a 2% soln. of which has viscosity 10 cP at 20 degrees C.
Intensive therapy for aphasia has been demonstrated to improve language functioning after stroke or other neurological injury. However, recovery is generally not complete and new therapies are needed to improve outcomes. Transcranial direct current stimulation (tDCS) has been shown to improve outcomes with motor therapy after stroke. This study will examine the feasibility of using tDCS supplementing clinically determined intensive language therapy as a way of enhancing language outcomes in aphasia. Eligible clients enrolled in the University of Michigan Aphasia Program (UMAP) will be invited to participate in the study. Clients will receive 20 minutes of tDCS every day along with their usual treatment protocol. Pre and post testing will be completed to assess for improvement in language functioning. This is a feasibility and proof of concept study to determine if a randomized control trial should be pursued
Speech-language pathologists and board-certified behavior analysts both provide important support services to children who are candidates for augmentative and alternative communication. Current assessment practices neglect critical socioecological factors that are necessary to inform communication-based interventions. By leveraging the unique knowledge, research, and expertise of both disciplines, an interprofessional approach to assessment may help realize individualized or precision interventions and personalized supports that address the unique communication needs of each person. The purpose of this article is to introduce a process-based approach to assessment called the "Applied Model of Interprofessional Collaboration-Assessment (AMIC-A)." The AMIC-A will be defined and detailed including the rationale for development, a description of the approach, and recommendations for implementation. A case study example is provided to illustrate implementation of the AMIC-A.
Collagenase Injection (CI) involves the injection of collagenase clostridium histolyticum (0.58 mg), directly into the Dupuytren's cord. The patient then returns to see the surgeon within one week, has local anaesthetic is administered, and an extension force is applied to the affected digit to rupture the already weakened cord.
Bladder Cancer is the fifth most common cancer in the USA. The primary treatment for invasive bladder cancer is chemotherapy followed by RC. Patients undergoing this surgery are at risk for complications. Being malnourished can increase the risk of mortality by three times. The patients also suffer from taste alterations after chemotherapy and gastrointestinal disturbances such as diarrhea and constipation. These can lead to poor nutritional intake and malabsorption of nutrients.

This study is being done to develop an educational video series for patients undergoing RC and assess their impact. The videos are created to address the nutritional needs of these patients and improve their outcomes after surgery.
The present invention relates to a kind of anthraquinone derivative and preparation method thereof and application, first to soft coral endogenetic fungus Alternaria during preparation? sp. (ZJ-2008003) carries out spawn culture in bacterium culture medium, fermentation culture in the fermentation medium again, by gained filtering fermentation liquor, removing thalline obtains filtrate, gained filtrate is extracted with ethyl acetate; Silica gel column chromatography, Sephadex is carried out after extraction liquid is concentrated? LH-20 gel filtration chromatography and the preparation of half preparative high-performance liquid chromatographic, concentrate gained elutriant, obtain clear crystal, compound tetrahydroaltersolanols? C-E; Obtain pink powder, compound tetrahydroaltersolanol? F.The anthraquinone derivatives deriving from thalassiomycetes of the present invention has strong antivirus action, effectively can suppress porcine reproductive and respiratory syndrome virus (PRRSV), can be used as antiviral, and raw material can carry out scale operation, has a extensive future.
FIELD: medicine.SUBSTANCE: inventions group relates to medicine, namely to tissue engineering, regenerative medicine, traumatology and orthopedics, and can be used to restore bone tissue in the area of a bone defect. The method includes: installing a temporary insert-spacer corresponding to the size of the defect in the area of the bone defect; removal of the temporary spacer insert is performed 7-30 days after installation; installation of a perforated resorbable membrane with adhered cellular spheroids from the autologous periosteum deposited on its surface. In this case, the perforated membrane is folded in the form of a cylinder and is attached to the periosteum of the ends of the bone sawdust using surgical sutures. In special cases, the temporary spacer insert is made of polymethyl methacrylate, the resorbable membrane is made of a biodegradable material, the biodegradable material is selected from an allogeneic lyophilized periosteum. At the same time, when installing a perforated membrane with cellular spheroids, it is fixed at the edges with suture absorbable threads, the subject is a human, the bone defect is a defect in the tubular bone, a temporary spacer insert is installed in the form of a cylinder, and the cavity inside the membrane is filled with alginate gel. The resorbable membrane is collagen barrier membrane, holes of which have a diameter of 150-350 microns, the distance between the centers of the holes is 550-1000 microns and can be 10-50% of the total surface area of the entire membrane.EFFECT: invention provides the ability to restore bone tissue in the area of a bone defect by growing bone regenerate in the area of the de novo de novo on a perforated resorbable membrane with adhered cell spheroids from the autologous periosteum deposited on its surface.14 cl, 1 ex
The experimental group will be provided with smoking cessation training based on the transtheoretical model.Individuals will be required to use the mobile application for 6 months. Measurements will be made at 1, 3, and 6 months.
BACKGROUND/AIM: Esophagogastroduodenoscopy (EGD) is an effective screening method for early detection of gastric cancer. The GAGLESS mouthpiece has a structure that widens the pharyngeal cavity and suppresses the pharyngeal reflex. This study aimed to investigate the acceptability, safety, and feasibility of transnasal and peroral ultrathin endoscopy using GAGLESS mouthpieces (Clinical Trial Number: UMIN000036922).
PATIENTS AND METHODS: This study was a multicenter, prospective, randomized, open-label trial performed using a questionnaire. The study included 101 consecutive patients who visited the participating medical institutions between June 2019 and March 2022 (median age=47 years, range=24-87 years; all male). Patients aged ≥20 years at the time of consent acquisition who were the first to undergo EGD were included in the study. The primary endpoint was the degree of distress during EGD, as determined using a visual analog scale (VAS).
RESULTS: The VAS score during endoscopic passage through the pharynx was significantly better in the transnasal endoscopy group than in the oral endoscopy group (2.420 vs. 4.092, p=0.001). There was no significant difference in the VAS scores between the two groups during anesthesia or throughout the examination. Compared with nasal endoscopy, oral endoscopy with a GAGLESS mouthpiece did not reduce the VAS score but did significantly improve gastric visibility.
CONCLUSION: For patients in whom there was difficulty in inserting a nasal endoscope, using a GAGLESS mouthpiece rather than a conventional mouthpiece may be more useful in reducing pain.