anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Simple hepatic cysts (SHC) are generally asymptomatic and incidentally diagnosed using imaging studies. Asymptomatic SHC does not require treatment, but symptomatic SHC warrants treatment using different modalities, including intravenous antibiotic therapy, ultrasound-guided percutaneous catheter drainage (PCD) with sclerotherapy, and surgery. The dissemination of endoscopic ultrasonography (EUS) intervention techniques has enabled the performance of puncture and drainage via the transgastrointestinal route for intra-abdominal abscesses. Despite the development of an EUS-guided drainage method for treating symptomatic SHC, only a few case reports using this method have been reported. This study retrospectively analyzed the safety and feasibility of EUS-guided drainage of symptomatic SHC as well as its clinical outcomes and compared it with combined therapy using PCD and minocycline sclerotherapy. The records of 10 consecutive patients with 11 symptomatic SHCs treated with either EUS-guided drainage or PCD combined with minocycline sclerotherapy at the Musashino Tokushukai Hospital from August 2019 to January 2024 were retrospectively examined. All cases in both groups achieved technical and clinical success, with no reported adverse events. The median reduction rates of the major cyst diameters in the EUS-guided drainage and PCD with sclerotherapy groups were 100% (interquartile range [IQR]: 94%-100%) and 67% (IQR: 48.5%-85%). The length of hospital stay was 7 and 22.5 days in the EUS-guided and PCD with sclerotherapy groups (P = .01). EUS-guided drainage of symptomatic SHC is a safe and effective therapeutic alternative to percutaneous drainage with sclerotherapy and surgery for treating symptomatic SHC.
The invention discloses a tilmicosin submicron powder water soluble preparation and a preparing method thereof, and belongs to the technical field of veterinary medicine preparing. The tilmicosin submicron powder water soluble preparation is soluble powder. The tilmicosin submicron powder water soluble preparation is prepared from, by mass, 15%-35% tilmicosin, 15%-35% PVPK30, 15-35% of PEG6000, 5%-20% L-arginine and 1%-5% Tween-80. The tilmicosin submicron powder water soluble preparation does not degrade, specific surface area is increased, the preparation can be well dispersed and easier to be absorbed, the dissolution rate of the tilmicosin is greatly increased, and the preparation has low moisture and few impurities. An acceleration test and long-term test inspection show that the preparation has good stability. A pharmacodynamic test is conducted on the prepared tilmicosin submicron powder water soluble preparation and finds that therapeutic effect for respiratory disease of the preparation is significantly higher than that of ordinary tilmicosin water soluble powder, the cure rate reaches up to 89.6%, and the effective rate reaches up to 94.6%.
Preparations for repelling insects are obtained by incorporating coumarin or a substitution product thereof, or phthalic acid diethyl ester, with a water-soluble salt of an alkaline earth metal or magnesium in an organic solvent such as ethyl or isopropyl alcohol or glycerin.  A small amount of water may also be present.  It is stated that double compounds are probably formed.  Salts specified are the bromides of strontium, calcium and magnesium, the chlorides of calcium and magnesium, and magnesium sulphate.ALSO:Preparations for warding off insects are obtained by incorporating coumarin or a substitution product thereof, or phthalic acid diethylester, with a water-soluble salt of an alkaline earth metal or magnesium in an organic solvent, preferably an alcohol such as ethyl alcohol, isopropanol or glycerin.  Water may be present in an amount not exceeding 15 per cent and perfumes or cosmetics may be added.  It is stated that probably double compounds are formed between the organic compound and the salts when these are dissolved in the solvent.  When an emulsion, paste or powder is required solution is effected in presence of agents such as kieselguhr, talcum, plaster of Paris, wax, starch, or octodecyl alcohol.  According to examples coumarin may be mixed with calcium chloride and 96 per cent alcohol; or with clove oil, strontium bromide, calcium chloride and 85 per cent alcohol; or with calcium chloride, magnesium chloride, alcohol and water; or with 96 per cent alcohol, octodecyl alcohol, and calcium chloride; or phthalic acid diethyl ester may be mixed with magnesium bromide, calcium bromide, isopropanol and water.
Composition and methods for affecting cell proliferation, metabolism or sensitization, including the potentiation of proteasome inhibitor therapy for the treatment of disease caused by deregulation of ubiquitin-proteasome systems, in a cell or subject. The composition includes a compound in combination with a ubiquitin-proteasome inhibitor. In one embodiment, the compound has the formula C42H35N5O3 and the ubiquitin-protease inhibitor is a proteasome inhibitor or an inhibitor of another component of the ubiquitin-proteasome pathway such as an E3 ubiquitin ligase. In one embodiment of the method, the compound is administered to a cell or subject and a therapeutically effective amount of a ubiquitin-protease inhibitor is also administered. In another embodiment, the compound is administered to a cell or subject to inhibit cell proliferation. In yet another embodiment, the compound is administered to a cell or subject to increase, or augment, glucose utilization.
The importance of the immune microenvironment in poorly cohesive carcinoma (PCC) has been highlighted due to its limited response rate to conventional therapy and emerging treatment resistance. A combination of clinical cohorts, bioinformatics analyses, and functional/molecular experiments revealed that high infiltration of Interferon Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) + tumor-associated neutrophils (TANs) is a distinguishing feature of PCC patients. Upregulation of IFIT1 + TANs promote migration and invasion of gastric cancer (GC) cell lines (MKN45 and MKN74) and stimulates the growth of cell-derived xenograft models. Besides, by promoting macrophage secreted phosphoprotein 1 (SPP1) expression and facilitating cancer-associated fibroblast and endothelial cell recruitment and activation through TANs, IFIT1 promotes a mesenchymal phenotype, which is associated with a poor prognosis. Importantly, compared to non-PCC (NPCC), PCC tumors is more immunosuppressive. Mechanistically, IFIT1 can be stimulated by IFN-γ and contributes to the expression of Programmed Cell Death 1 Ligand (PDL1) in TANs. We demonstrated in mouse models that IFIT1 + PDL1 + TANs can induce acquired resistance to anti-PD-1 immunotherapy, which may be responsible for the difficulty of PCC patients to benefit from immunotherapy. This work highlights the role of IFIT1 + TANs in mediating the remodeling of the tumor immune microenvironment and immunotherapeutic resistance and introduces IFIT1 + TANs as a promising target for precision therapy of PCC.
Atrial fibrillation (AF) characterized by a fast and anarchic electrical activation of the atria, results in uncoordinated and inefficient atrial contractions that increases the risks of heart failure and strokes. Besides being a major source of morbidity and mortality, AF is one of the most common heart condition and its prevalence increases with age. Radiofrequency catheter ablation of AF has become one of the treatment of choice in AF resistant to conventional antiarrhythmic drugs. For paroxysmal AF, the ablation strategy is clear and consists in complete pulmonary veins isolation (PVI). However, if this strategy works well in paroxysmal AF, the recurrences rate remains high in persistent AF. Beyond PVI, the ablation strategy that has prevailed over the past two decades remains controversial: the left atrium partition using linear lesions ("cox-maze" strategy); the mapping of the left atrium in AF to identify and localize the arrhythmia sources. Both methods have, besides favoring atrial flutters, failed to demonstrated superiority compared to PVI alone (as showed by the clinical trial STAR AF 2). The investigators aims to test a new method of ablation for patients suffering from persistent AF in order to decrease post ablation recurrence. They propose a strategy targeting the native structures facilitating reentries including the ligament of Marshall (LOM), an embryological remnant. Indeed, two studies have demonstrated that LOM could be the source of focal activities, the substrate of reentries and a strong parasympathetic modulator. For these reasons, LOM may represent a major target in AF treatment besides PV isolation. To date, ablation techniques do not ensure the complete destruction of the Marshall's musculature and parasympathetic ganglia that surround it, largely isolated by a sheath of adipose tissue. To overcome this technical limitation, LOM elimination can be achieved by alcohol injection into the vein of Marshall. This innovative approach will then consist in 3 consecutive steps: 1) the destruction of Marshall bundles by ethanol infusion followed by the ablation of the distal and proximal muscular ramification (coronary sinus and ridge); 2) the standard PV isolation; 3) the linear lesions: the mitral, the roof and of the cavo-tricuspid isthmus, main causes of recurrence in atrial flutter.
Twenty nine female recreational dancers from a University dance team volunteered to take part in the study. A 3-day food diary and activity log completed prior to testing determined that there were no differences in physical activity levels or energy and macronutrient intakes between participants. Subjects were asked to replicate their reported diets as closely as possible throughout the testing period. A menstrual cycle questionnaire was also completed in order to determine menstrual cycle phase; all testing took place during the early/mid luteal phase.

Participants were randomly assigned to two exercise groups designed to induce EIMD; either a dance-specific protocol (DPFT) or a sport-specific repeated sprint protocol (SSRS). Participants completed the DPFT (n=15) or SSRS (n=14) and a battery of commonly used muscle damage indices were measured pre, immediately post and 24-, 48-, and 72 h post muscle damage. These were; delayed onset muscle soreness (DOMS), limb girth, countermovement jump height (CMJ), reactive strength index (RSI), maximal voluntary isometric contraction (MVC) sprint performance, and total creatine kinase (CK) activity. Participants were tested at the same time on subsequent days (± 1 h) to account for diurnal variation. Participants were asked to avoid strenuous exercise, alcohol, caffeine, nutritional supplements and any anti-inflammatory drugs or alternative treatments for the duration of the study.

Statistical software (IBM SPSS v21, IBM, USA) was used for inferential analysis and significance was accepted at the P \< .05 a priori. Mauchley's test assessed the sphericity of the data and where appropriate, violations were corrected using the Greenhouse-Geisser. To explore our first objective, a one-way analysis of variance (ANOVA) with repeated measures (group, 1; time, 5) was performed on all variables in order to analyse the muscle damage response to the DPFT. For the second aim a two-way ANOVA with repeated measures (group, 2; time, 5) was used for all variables to allow for comparison of the muscle damage response between the DPFT and the SSRS. Where appropriate LSD post-hoc analysis was performed.
The present invention relates to medicine capable of tranquilizing and relieving trouble for treating depression, which takes natural Chinese herbal medicine compositions as raw materials and is prepared by extracting and preparing. The present invention is characterized in that components of the medicine contain herba hyperici sampsonii extracts and borneol medicine raw materials. The weight proportion of the components is 30 to 60 of the herba hyperici sampsonii to 0.2 to 0.5 of the borneol. The present invention can be prepared into decoction mixtures and capsules. Compared with the prior art, the present invention has functions of depression and anxiety resistance, has curative effects which are equivalent to the medicine in the prior art, and has a certain functions for improving emotions of patients, increasing activity, increasing appetite and improving sleep. The present invention has little bad reaction degree, can be accepted by patients, and is safe medicine of which the safety is obviously better than the traditional antidepressant medicine because the medicine has little toxicity and does not need special treatment. The present invention is especially suitable for the treatment of light and moderate depression patients. The present invention can largely reduce the economic burden of patients who has a long course of treatment and large dosages in medical care cost aspect because the daily treating cost is only about 1 yuan RMB.
BACKGROUND: Microbial infection and colonization are frequently associated with disease progression and poor clinical outcomes in bronchiectasis. Identification of pathogen spectrum is crucial for precision treatment at exacerbation of bronchiectasis.
METHODS: We conducted a prospective cohort study in patients with bronchiectasis exacerbation onset and stable state. Bronchoalveolar lavage fluid (BALF) was collected for conventional microbiological tests (CMTs) and metagenomic Next-Generation Sequencing (mNGS). Bronchiectasis patients were monitored for documenting the time to the next exacerbation during longitudinal follow-up.
RESULTS: We recruited 168 eligible participants in the exacerbation cohorts, and 38 bronchiectasis patients at stable state at longitudinal follow-up. 141 bronchiectasis patients at exacerbation onset had definite or probable pathogens via combining CMTs with mNGS reports. We identified that Pseudomonas aeruginosa, non-tuberculous mycobacteria, Haemophilus influenzae, Nocardia spp, and Staphylococcus aureus were the top 5 pathogens with a higher detection rate in our cohorts via combination of CMTs and mNGS analysis. We also observed strong correlations of Pseudomonas aeruginosa, Haemophilus influenzae, non-tuberculous mycobacteria with disease severity, including the disease duration, Bronchiectasis Severity Index, and lung function. Moreover, the adjusted pathogenic index of potential pathogenic microorganism negatively correlated (r = -0.7280, p < 0.001) with the time to the next exacerbation in bronchiectasis.
CONCLUSION: We have revealed the pathogenic microbial spectrum in lower airways and the negative correlation of PPM colonization with the time to the next exacerbation in bronchiectasis. These results suggested that pathogens contribute to the progression of bronchiectasis.
Hypoglycemic soluble granules containing alfalfas. The invention relates to the field of beverage. Alfalfa, radix astragali and corn stigma are employed as raw materials and are combined together to obtain a cooperative effect among each drug so that diabetes can be prevented and an immunity of a human body can be improved. The soluble granules have effects of reducing blood fat and blood glucose, alleviating digestion rate in the human body and most quickly excreting cholesterol so that the blood glucose and the cholesterol in blood can be controlled under a most ideal level. With pure plants as raw materials, a pharmacologic damage caused by side effect since a diabetes patient takes a western medicine. Meanwhile, the soluble granules are low in raw material cost so that common people are capable of purchasing the soluble granules. The soluble granules not only are an excellent health-caring product to the diabetes patients but also have a good health-caring effect on the common people.
The invention relates to a lotus seed facial mask. The active ingredients in a formula are essence extracted from pygmy water lily petals, marine organism complex enzymes, aloe juice, grape seed oil, natural citric acid, and the like. The lotus seed facial mask is prepared by compounding the active ingredients through special processes. The lotus seed facial mask belongs to the technical field of cosmetic making. The lotus seed facial mask is mainly used for intensive care of facial skins, including oxidation resistance, dimness prevention and skin brightening, and can go deep into the dermis of the skins to resist free radicals of cells and improve skin elasticity. The lotus seed facial mask has the advantages that (1) the lotus seed facial mask is unique in ingredients and has obvious oxidation resistance effects by using the essence extracted from pygmy water lily petals as a main oxidation resistant ingredient; (2) as an oil matrix, the grape seed oil has small molecules and is easy to absorb; (3) as a colloidal matrix, the natural aloe juice is easy to absorb and has obvious moisturizing effects; (4) the lotus seed facial mask has good antibacterial effects and long shelf life by using natural antibacterial agents extracted from marine organisms; (5) the lotus seed facial mask is a pure natural environment-friendly product, has a wide range of application to the crowd and is non-toxic and non-irritant.
The invention provides a traditional Chinese medicine formula for treating rheumatism. The traditional Chinese medicine formula comprises rhizomes of Chinese atractylodes, clematis roots, notopterygium roots, Chinese taxillus twigs, fineleaf schizonepeta herb, lindera angustifolia Cheng, schisandra rubriflora (Franch.) Rehd.etWils., trident maple, common clubmoss herb, piper wallichii (Miq.) Hand.-Mazz. var hupehense (DC.) Hand.-mazz., rhizomes of Chinese atractylodes, roots of cudrania cochin chinensis (Lour.) Kudo et Masam., Japanese saussurea herb, glutinous rice and pig bones. The invention further provides a preparation method of the traditional Chinese medicine formula for treating the rheumatism. The traditional Chinese medicine formula has the advantages that based on the fact that the clematis roots are capable of well dispelling wind, eliminating dampness and activating meridians to stop pain and the schisandra rubriflora (Franch.) Rehd.etWils. is capable of treating rheumatic arthritis effectively, the traditional Chinese medicine formula added with the Chinese atractylodes, the notopterygium roots, the Chinese taxillus twigs, the fineleaf schizonepeta herb, the lindera angustifolia Cheng, the trident maple, the common clubmoss herb, the piper wallichii (Miq.) Hand.-Mazz. var hupehense (DC.) Hand.-mazz., roots of cudrania cochin chinensis (Lour.) Kudo et Masam. and the Japanese saussurea herb is capable of dispelling wind, eliminating dampness and promoting qi and blood circulation and free from any toxic or side effect. Additionally, the preparation method has the advantage that a patient can absorb decoction effectively after eating the glutinous rice containing the decoction.
Patients in the PRP group will receive both shoulder joint (GHJ) and SASD bursa injection for 2 times in 2-week interval. PRP will be prepared by taking 10ml venous blood which is then mixed with 2ml of thrombin and centrifuged in a specially designed tube at 3400 rotations per minute (rpm) for 15 minutes. About 2ml PRP and 3ml platelet poor plasma (PPP) will be extracted, then 4ml 1% xylocaine will be added to make 9ml injectate. 6ml injectate will be injected into the posterior GHJ with a 7 cm 23-gauge needle under ultrasound (US) guidance. Another 3ml injectate will be injected into the SASD bursa of the affected shoulder with a 3.8 cm 22-gauge needle under US guidance. Physical therapy will be conducted for 8 weeks.
The volunteers to be included in our study will be selected from chronic stroke patients who are receiving physical therapy at Bursa İlker Çelikcan Physical Therapy and Rehabilitation Hospital and have a history of falling. The study will consist of two separate groups, core stabilization and multifactorial education group. Patients who suitable the inclusion criteria will be randomized according to the order of initiation of the physical therapy program in the hospital and divided into groups. Both groups will participate in a multifactorial education program. In this program program, there are physical therapy and rehabilitation practices that are routinely applied in stroke rehabilitation and that patients will receive at the specified hospital. In the content of these applications; patient-specific upper and lower extremity stretching, relaxation and strengthening exercises; balance, coordination and gait training are included.In addition to these, patients in the intervention group will perform core stabilization exercises under the supervision of a physiotherapist. The exercises will be applied 5 times a week for 6 weeks. First of all, activation of the "transversus abdominis" muscle, which forms the basis of core stabilization, will be taught to patients. "Chattanooga Stabilizer Pressure Biofeedback Device" will be used in order to teach this activation and to observe whether the patient is doing it correctly during exercises. The exercises will be made more difficult by adding extremity movements to this activation. Evaluations will be made twice, at the beginning (0. week) and end of the treatment (13. week).In order to evaluate the effect of the treatment on the fall, the number of falls that occurred within 3 months after the end of the treatment will be questioned by phone.
BACKGROUND: Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinopathies with neovascularization (NV). Neuronal/glial-vascular interactions influence the release of angiogenic and neurotrophic factors. We hypothesized that botulinum neurotoxin serotype A (BoNT/A) modulates pathological endothelial cell proliferation through glial cell activation and growth factor release.
METHODS: A laser-induced choroidal NV (CNV) was employed to investigate the anti-angiogenic effects of BoNT/A. Fundus fluorescence angiography, immunohistochemistry, and real-time PCR were used to assess BoNT/A efficacy in inhibiting CNV and the molecular mechanisms underlying this inhibition. Neuronal and glial suppressor of cytokine signaling 3 (SOCS3) deficient mice were used to investigate the molecular mechanisms of BoNT/A in inhibiting CNV via SOCS3.
FINDINGS: In laser-induced CNV mice with intravitreal BoNT/A treatment, CNV lesions decreased > 30%; vascular leakage and retinal glial activation were suppressed; and Socs3 mRNA expression was induced while vascular endothelial growth factor A (Vegfa) mRNA expression was suppressed. The protective effects of BoNT/A on CNV development were diminished in mice lacking neuronal/glial SOCS3.
CONCLUSION: BoNT/A suppressed laser-induced CNV and glial cell activation, in part through SOCS3 induction in neuronal/glial cells. BoNT/A treatment led to a decrease of pro-angiogenic factors, including VEGFA, highlighting the potential of BoNT/A as a therapeutic intervention for pathological angiogenesis in retinopathies.
An improved cosmetic lotion having desirable rheology is disclosed as comprising a dissolved mannogalactan gum and as a dispersed phase swollen hydrated particles of algin salt containing cations selected from the group consisting of calcium and aluminum. The ratio by dry weight of the algin salt to the gum is from about 5:1 to about 3:1 and desired rheology is obtained by controlling the cation content selected from the group calcium and aluminum relative to the content of the algin salt so that the viscosity of the lotion at 25* C. is from about 5,000 to about 20,000 cps. when the concentration of the algin salt in the lotion is from about 0.5 percent to about 1.1 percent. The gum concentration is from about 0.14 percent to about 0.24 percent. The lotion may contain beneficiating materials such as glycerine and alcohol. It preferably contains boric acid which has a modifying effect on the gum and, in addition, an acid such as fumaric. The invention relates to the lotion and for use in making it a solid composition and a glycerine base slurry. Its production involves equilibrating cation concentration from suitable cation sources for obtaining desired rheology.