anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Biologically pure cultures of human enteric coronaviruses A-14 and C-14 have been prepared. The serial cultivation of viruses from fecal samples of infant patients suffering from necrotizing enterocolitis resulted in the obtainment of the biologically pure cultures. This serial cultivation was in an antibiotic-supplemented medium for mammalian cell culture preferably Leibovitz L-15 medium (pH 6.8), which contained fetal human intestinal pieces. Infections by human enteric coronavirus may be immunochemically diagnosed by use of antibodies against the A-14 and C-14 coronaviruses. Such antibodies have been prepared and found to bind strongly to coronavirus A-14 or C-14 and not to OC43, 229E, MHV-A59 and Breda 1 and 2 viruses. Fecal samples from patients suffering from enteric disease can be interacted with antibody and the amount of binding between the antibody and antigens of the sample measured by any of several means well-known in the art. When the binding between the antibody and antigens of a patient's fecal sample is determined to be significantly greater than that found between the antibody and antigens of a fecal sample from a control uninfected individual which usually demonstrate no interaction, a positive diagnosis of infection by human enteric coronavirus is obtained.
Understanding the molecular mechanisms underlying the generation of absence seizures is crucial for developing effective, patient-specific treatments for childhood absence epilepsy (CAE). Currently, one-third of patients remain refractive to the antiseizure medications (ASMs), previously called antiepileptic drugs (AEDs), available to treat CAE. Additionally, these ASMs often produce serious side effects and can even exacerbate symptoms in some patients. Determining the precise cellular and molecular mechanisms directly responsible for causing this type of epilepsy has proven challenging as they appear to be complex and multifactorial in patients with different genetic backgrounds. Aberrant neuronal activity in CAE may be caused by several mechanisms that are not fully understood. Thus, dissecting the causal factors that could be targeted in the development of precision medicines without side effects remains a high priority and the ultimate goal in this field of epilepsy research. The aim of this review is to highlight our current understanding of potential causative mechanisms for absence seizure generation, based on the latest research using cutting-edge technologies. This information will be important for identifying potential targets for future therapeutic intervention.
This scoping review synthesizes evidence on metformin's use during pregnancy, encompassing diverse conditions like gestational diabetes, type 1 and type 2 diabetes, polycystic ovary syndrome (PCOS), and obesity. Metformin demonstrates comparable efficacy to insulin in gestational diabetes, positive outcomes in type 2 diabetes pregnancies, and potential benefits in reducing complications. The review highlights nuances in its effects across conditions, indicating advantages such as reduced risk of macrosomia and cesarean section in gestational diabetes. However, its prophylactic role in preventing gestational diabetes and associated complications remains inconclusive. In obese pregnant women, mixed results are observed, with potential benefits in reducing pre-eclampsia risk. Metformin shows promise in preventing preterm birth and late miscarriage in PCOS pregnancies. Categorizing patient subgroups is crucial for identifying advantages, especially in gestational diabetes and type 2 diabetes. Challenges arise from study heterogeneity, necessitating standardized indications for dosage, timing, and postpartum follow ups. Efforts to identify patient characteristics influencing metformin efficacy are crucial for tailored therapy. Although metformin emerges as a viable option in complicated pregnancies, comprehensive research, standardized protocols, and subgroup identification efforts will enhance clinical utility, ensuring evidence-based therapies and optimal maternal and fetal outcomes. Bridging existing knowledge gaps remains imperative for advancing metformin's role in pregnancy management.
Following the enrollment period, subjects will enter a six-week randomized treatment period with either lithium or paroxetine. Lithium carbonate will be commenced at 600mgs hs, with increase to 900mgs at day 7. Dose will be flexibly titrated to give a serum level between 0.5 and 1.1mmol/l. At visit 4, the dose of lithium may be adjusted (within the range of 0.6 and 1.1 mmol/l).
RNA N6-methyladenosine (m6A) readers mediate cancer progression. However, the functional role and potential mechanisms of the m6A readers in prostate cancer tumorigenicity remain to be elucidated. In this study, we demonstrate that YTHDF3 expression is elevated in castration-resistant prostate cancer (CRPC) and positively correlated to high grade, bone metastasis and poor survival. YTHDF3 expression promoted CRPC cell proliferation, epithelial to mesenchymal transition (EMT) and tumour progression. Mechanistically, YTHDF3 promoted the RNA degradation of SPOP and NXK3.1 but stabilized RNA expressions of TWIST1 and SNAI2 dependent on m6A to facilitate cell proliferation and EMT. Additionally, YTHDF3 expression enhanced AKT activity via degrading SPOP in an m6A-dependent manner. Importantly, we found that melatonin can compete with m6A to occupy the m6A-binding cage of YTHDF3, leading to inhibition of YTHFD3 and its target expressions as well as CRPC tumour growth. Our findings uncover an essential role of YTHDF3 in the progression of CRPC and highlight the role of melatonin in anti-CRPC activity.
This group will receive the standard specialist physiotherapy intervention for bladder pain syndrome for 6 weeks, but will also be provided with an intra-vaginal therapeutic wand and taught how to use it. They will then be asked to use the therapeutic wand at home twice a week to release and relax their pelvic floor muscles for 5 minutes.
BACKGROUND: Balance and mobility deficits are major concerns in stroke rehabilitation. Virtual reality (VR) training and Swiss-ball training are commonly used approaches to improve balance and mobility. However, no study has compared the efficacy of VR training, Swiss-ball training, and their combination in improving balance and mobility function or investigated cortical activation and connectivity in individuals with stroke.
METHODS: A prospective, single-blinded, parallel-armed, multi-center randomized controlled trial with factorial design will be conducted. Seventy-six participants aged 30-80 years with stroke will be recruited. Participants will be allocated to one of the four groups: (A) the VR training + Swiss-ball training + conventional physical therapy group; (B) the Swiss-ball training + conventional physical therapy group; (C) the VR training + conventional physical therapy group; or (D) the conventional physical therapy group. All participants will receive 50 min of training per day, 5 times per week, for a total of 4 weeks. The primary outcomes will be balance and mobility measures. Secondary outcomes will include the 10-min walk test, dynamic gait index, and cortical activation. Outcomes will be measured on three occasions: at baseline, after the training, and at the 4-week follow-up.
DISCUSSION: This trial will provide evidence to determine whether there are differences in clinical outcomes and cortical activation following two different types of exercise programs and their combination, and to elucidate the recovery mechanisms of balance and mobility function in individuals with stroke.
TRIAL REGISTRATION: Chinese Clinical Trial Registry reference: www.chictr.org.cn (No. ChiCTR2400082135). Registered on May 24, 2024.
After selective carious tissue removal, the universal adhesive (Adper Universal; 3M ESPE, St. Paul, MN, EUA) will be applied on the cavity walls. The cavity will be restored using a single increment of Filtek One Bulk Fill (3M ESPE, St. Paul, MN, EUA).
PURPOSE:To provide a hair tonic containing the extract of herb drugs SANSHO (peel of Zanthoxylum piperilum), SANZASHI (fruit of Crataegus pinnatifida), TOUKI (root of Angelica acutiloba), TOUGARASHI (fruit of Capsicum annum) and SHOKYO (rhizome of Zangiber officinale), having hair-tonic and hair- growing effect, increasing the peripheral blood flows by dilating the local peripheral vessel of bald part and effective in promoting the activation of hair root. CONSTITUTION:The objective hair tonic contains the extract of 5 kinds of herb drugs consisting of SANSHO, SANZASHI, TOUKI, TOUGARASHI and SHOKYO. The weight ratios of the extracts of the above 5 kinds of herbs are 2-10pts. (preferably 3-9pts.) of SANSHO, 10-30pts. (preferably 15-25pts.) of SANZASHI, 5-10pts. of TOUKI, 1-6pts. of TOUGARASHI and 5-20pts. (preferably 6-15pts.) of SHOKYO. These components are easily available and the present agent can be produced extremely easily at a low cost.
Within the framework of a six-month observation period, the investigators intend to identify risk factors of the patient collective for the development of postoperative delirium. For this purpose, a preoperative risk assessment is performed, which includes cognitive and physical performance as well as premedication and concomitant diseases. Included are patients of at least 65 years of age of defined specialties. Postoperatively, patients who have undergone the assessment are tested for delirium once per shift until the third postoperative day and severity and duration are documented. After completion of the observation period, risk factors favoring the development of postoperative delirium will be identified. In the subsequent intervention period, patients from the age of 65 years with an additional identified risk factor will receive standardized, targeted perioperative care. This includes both adherence to preventive measures in accordance with guidelines and the recommendation of therapeutic measures if a delirium is diagnosed. Through the standardized, interprofessional and interdisciplinary application of the described approach, the investigator aim to reduce the incidence, duration and severity of postoperative delirium. Furthermore, the evaluation of the identification of the weighting of risk factors as well as the identification of risk factors by the tests performed, length of hospital stay, three-month mortality and daily living skills after three months. In addition, a baseline EEG (standardized awake EEG before initiation) is recorded in a subgroup to determine whether patients at risk for delirium can be identified and whether intraoperative EEG parameters support the delirium risk assessment.
Aortic valve stenosis is a disease in which the leaflets of the aortic valve become scarred and calcified. This leads to a severe narrowing of the valve orifice, which causes chest pain, heart failure and eventually death. The condition is currently treated with open chest surgical valve replacement on cardiopulmonary bypass. Heart Leaflet Technologies has developed an aortic valve prosthesis that can be delivered to the stenotic aortic valve through a catheter inserted in the femoral artery.

The purpose of this study is to confirm that the dimensions of the HLT valve are appropriate for patients with aortic valve stenosis. There is no animal model of aortic valve stenosis. Heart Leaflet Technologies has performed extensive device geometry and deployment testing on fixed cadaveric hearts with calcified cusps and aortic stenosis. HLT has also performed a number of preclinical animal experiments to verify deliverability and device function in vivo.
A medical device information technology ("IT") data transfer system in one embodiment includes a cluster domain, an external domain and an interface domain. Equipment belonging to the cluster domain may communicate in real time such that availability, safety, security, reliable integrity and performance are guaranteed. The external domain includes equipment not enabled for direct inclusion in the cluster domain, and may include equipment for external information systems, presentation equipment, personal computer equipment, shared medical equipment and bedside medical equipment. The interface domain enables external domain equipment to communicate with cluster equipment in a bidirectional manner. Communication may be via certain access nodes in the cluster. The access nodes enable exchange of information between the open external domain and the closed and private cluster domain.
In one aspect, a method for forming particles is provided. The method may allow biocompatible particles comprising an agent (e.g., pharmaceutically active agent) to be produced absent one or more purification step (e.g., removal of excess reagent). In certain embodiments, particles, produced as described herein, can be utilized in a pharmaceutical composition and/or administered to a subject without further purification. The lack of one or more purification step may simplify manufacturing and/or minimize or eliminate the loss of agent from the particle after formation. In some embodiments, the method comprises associating albumin with an agent and crosslinking to form particles, such that little or no cytotoxic molecules are produced and/or remain after particle formation. Cross-linked albumin particles formed via the methods described herein may serve as biocompatible carriers for a variety of agents.
Depression affects around 50% of people with Multiple Sclerosis (pwMS) during their lifetime. PwMS are typically less physically active and spend twice as much time engaging in sedentary behaviour compared to the general population. Therefore, a better understanding of the factors associated with depression in pwMS, as well as the relationship between depression and sedentary behaviour and physical activity, is crucial for developing effective therapeutic strategies MS treatment. This study aimed to investigate whether the presence of depressive symptoms in pwMS is related to a longer duration of sedentary behaviour. Specially, the study assessed the relationship between depression and sedentary behaviour in women with relapsing-remitting MS (RRMS). The sample for this cross-sectional study consisted of 78 women, including 38 with relapsing-remitting MS (RRMS) (EDSS 1 to 3) and 40 healthy women. The study evaluated the depression and time in sedentary behaviour, levels of physical activity and subjective fatigue in three groups: women without MS (CG), women with MS and depression (MSD), and women with MS without depression (MSND). We found significant differences in sedentary behaviour time when comparing the group of women with MS to the group with MS and depression. The logistic regression analysis presents depression as a factor associated with sedentary behaviour in women with MS. This association became even stronger after adjustment in the multivariate model (odds ratio=1.62; 95% CI (1.13-2.64); p=0.021). Despite no differences in clinical disabilities (EDSS) or physical activity levels between the two MS subgroups (MSD and MSND), we observed a longer duration of sedentary behaviour among participants with MS and depression. There was no association with the level of physical activity. This suggests a relationship between depression and sedentary behaviour in women with MS, independent of the level of physical activity. Prolonged sedentary behaviour is a risk factor for other comorbidities, including cardiovascular disease, highlighting the importance of addressing both depression and sedentary behaviour in the management of MS. Studies that examine the amount of time pwMS spend in sedentary behaviour in various countries are crucial for developing more effective strategies tailored to different ethnicities and cultures.
FIELD: medicine, oncological pharmacology. SUBSTANCE: new preparation is elaborated based upon native squalene obtained out of deep-sea shark's oil or olive oil. Native squalene is activated by obtaining active derivatives of antitumor action. Activation is conducted due to heating, UV- or IR-irradiation, impact of oxygenous active form. EFFECT: new antitumor preparation based upon activated squalene with no cytostatic action upon healthy cells. 4 cl, 7 tbl, 5 ex, 13 fig
The invention relates to a preparation method of traditional Chinese medical lotion for treatment of dyspnea type ecthyma, belonging to the technical field of a preparation method of traditional Chinese medicine. At present, the dyspnea type ecthyma is treated generally with antibiotics and sulfonamides. If kanamycin is applied, toxicity can be caused to nerves and the kidney, respectively resulting in tinnitus, hearing loss and even permanent deafness related to the former and proteinuria, cylindruria and the like related to the latter. In the technical scheme, arillus longan, radix glehniae, rhizoma atractylodis alba, white lablab beans, radix panacis quinquefolii, radix ophiopogonis, red bayberry, egg yolk, medlar, codonopsis pilosula, mulberry fruit, astragalus mongholicus, rhizoma polygonati, polyporus lucidus, donkey-hide gelatin, polygonum multiflorum, angelica sinensis, radix rehmanniae preparata, radix paeoniae alba, triticum aestivum and liquorice are soaked in water and decocted by mild fire, and the prepared lotion is the traditional Chinese medical lotion for treatment of the dyspnea type ecthyma. The invention has the advantages that the traditional Chinese medical lotion can be manufactured easily and has small toxic and side effects, the treatment course is short, and the recovery rate is high. Moreover, adverse reactions of western medicine can also be avoided.
A 69-year-old woman had three syncopal events while flying on an airplane. She was found to be profoundly bradycardic. Two 12‑lead electrocardiograms (ECGs) showed ventricular rates in the thirties. In one, the QRS complexes were narrow. In the second ECG, there were wide negative deflections following the QRS complexes. Analysis of telemetry recordings revealed the underlying mechanism and helped establish appropriate programing of an implanted pacemaker.
Atherosclerosis stands out as one of the leading causes of global mortality. The inflammatory response against vascular wall components plays a pivotal role in the atherogenic process. The initiation of this process is notably driven by oxidized low-density lipoprotein (oxLDL) and a range of pro-inflammatory cytokines, with interleukin-1β (Il-1β) and tumor necrosis factor α (TNFα) emerging as particularly significant in the early stages of atherosclerotic plaque formation. In recent years, researchers worldwide have been diligently exploring innovative therapeutic approaches for metabolic diseases, recognizing their impact on the atherogenesis process. Our study aimed to investigate the influence of glucagon-like peptide 1 receptor agonists (GLP-1RA) on cytokine concentrations associated with the initiation of atherosclerotic plaque formation in a group of patients with type 2 diabetes and dyslipidemia. The study encompassed 50 subjects aged 41-81 (mean: 60.7), all diagnosed with type 2 diabetes, dyslipidemia and confirmed atherosclerosis based on B-mode ultrasound. Following a 180-day treatment with dulaglutide or semaglutide, we observed a statistically significant reduction in biochemical markers (oxLDL, TNFα and Il-1β) associated with the initiation of the atherosclerotic process (p < 0.001) within our study group. In addition to the already acknowledged positive effects of GLP-1RA on the metabolic parameters of treated patients, these drugs demonstrated a notable reduction in proinflammatory cytokine concentrations and may constitute an important element of therapy aimed at reducing cardiovascular risk.
PURPOSE:To provide a non-aqueous cosmetic containing an inorganic pigment coated with a water-soluble collagen (derivative) having an average molecular weight falling within a specific range, having excellent fittability and adhesivity to the skin and giving durable make-up and pleasant moist feeling to the skin. CONSTITUTION:The objective non-aqueous cosmetic contains an inorganic pigment coated with a water-soluble collagen or its derivative having an average molecular weight of 100,000-700,000 (e.g. succinylated collagen, methyl-esterified collagen, ethylesterified collagen, etc.). Since the coated pigment has high affinity to the skin and water-retainability, it is effective to maintain moistened skin. The water-soluble collagen is a protein extracted from the skin of calf, pigling, lamb, etc. The coated pigment can be produced by dispersing an inorganic pigment in an aqueous solution of the collagen, dehydrating and drying the obtained slurry under reduced pressure and pulverizing the dried product.
Activin A is known to impede tubular repair following renal ischemia, whereas exogenous follistatin, an activin A antagonist, has been shown to ameliorate kidney damage in rats. Despite these findings, the precise role of endogenous follistatin in the kidney has yet to be elucidated. In this study, we investigated the localization of follistatin in the normal human kidney and its potential utility as a marker for acute kidney injury (AKI). In a total of 118 AKI patients and 16 healthy adults, follistatin levels in serum and urine were quantified using ELISA, and correlations with clinical parameters were analyzed. Follistatin-producing cells were positive for Na-Cl co-transporter and uromodulin, but negative for aquaporin 1 and aquaporin 2. Unlike healthy adults, urinary follistatin significantly increased in AKI patients, correlating positively with AKI severity. Urinary follistatin levels were notably higher in patients needing renal replacement therapy. Significant correlations were observed with urinary protein, α1 microglobulin, and urinary NGAL, but not with urinary KIM-1, urinary L-FABP, urinary NAG, urinary β2 microglobulin, or serum creatinine. Interestingly, no correlation between urinary and serum follistatin levels was identified, indicating a renal origin for urinary follistatin. In conclusion, follistatin, produced by distal tubules, is detectable in the urine of AKI patients, suggesting its potential as a valuable marker for monitoring acute tubular damage severity in AKI.
The pulvurent effervescent topical treatment compositions comprise: at least 50%wt. of a gas generating system which comprises both a gas generating constituent as well as a complementary reactive acid constituent, which constituents, when combined in the presence of water or another largely aqueous medium generates a gas, preferably carbon dioxide; 5-50% wt. of an anionic soap and/or anionic surfactant constituent; 0.0001 – 1.5%wt. of an antimicrobial constituent; 0.0001 - 3 an exogenous product of  Sclerotium rolfsii , and, optionally one or more filler constituents, preferably based on materials which are inert with respect to the gas generating constituent and which also are inert with respect to the antimicrobial constituent; further optionally, one or more further constituents which may be included to provide a desired aesthetic benefit, e.g., a fragrance, colorant and/or a desired technical benefit, 15 e.g. an abrasive, to the pulvurent effervescent topical treatment compositions of which they form a part. The invention also provides effervescing, foamed topical treatment composition which are used as topical treatment compositions.
Anlotinib is an oral multi-targeted tyrosine kinase inhibitor (TKI) that strongly inhibits VEGFR, PDGFR, FGFR, and c-kit. Anlotinib (12 mg qd, d1-14; 21 days per cycle; total 5 cycles) Combined TAC×6 cycles.