anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to an antiviral, antibacterial and anti-inflammatory herbal injection for treating infectious diseases of livestock and fowls. Honeysuckle, forsythia, coptis, phellodendron, scutellaria, gardenia, indigowood leaves and isatis roots are grouped, are decocted by water for extracting effective parts, and are refined for removing impurities such as tannin, protein, starch, resin, etc. The present invention has the advantages of no side effect and safe use. The cure rate of the injection to virulent infectious diseases and bacterial infectious diseases achieves more than 98%. Moreover, the infectious diseases are difficult to recur. Bacteria are difficult to generate medicine resistance performance. The present invention avoids the residue of veterinary medicine and social public hazard.
FIELD: cosmetology. SUBSTANCE: the suggested innovation deals with cosmetic compositions containing sutured copolymer of metacrylic acid with C 1 -C 4 -alkylacrylate, cationic or amphoteric polymer at density of cationic charge being either above or equal to 1 meq/g, and polydialkylsiloxane with trimethylsilyl terminal groups. These compositions are applied, in particular, for washing and/or conditioning keratin materials, such as either hair or skin. The present innovation, also, deals with conditioning agent. The suggested composition provides high cosmetic properties for hair, such as softness, smoothness, tractability and aesthetic appearance. EFFECT: higher efficiency. 41 cl, 1 tbl
Youth with TD will receive four, 2-hour long sessions of evidence-based behavior therapy delivered in an intensive format. Participants will arrive an hour early for each session to take the d-cycloserine pill prior to starting each session of behavior therapy. Participants, therapists, and outcome assessors will be masked to pill condition.
The following relates to medical equipment technology, and in particular to radiology report technology. In one embodiment, an original radiological report and an addended radiological report are received. The original radiological report and the addended radiological report may be part of the same or separate documents. The original radiological report and the addended radiological report may be compared. Each difference may be classified and scored. A display device may be controlled to display at least one of the scores.
FIELD: food products. ^ SUBSTANCE: mentioned cacao components with increased content of polyphenol are obtained from unfermented cacao beans with fermentation factor 275 or lower. The method of crude cacao preparation includes frying cacao-beans or their kernels with fermentation factor 275 or lower. Fried cacao kernels or their parts or crude cacao obtained from cacao-beans or their mixtures have fermentation factor 275 or lower. The extract containing cacao polyphenol including cacao procyanidins is obtained be extraction with solvent of partially defatted cacao solids. The solids are obtained from cacao-beans or their kernels with fermentation factor 275 or lower fried till internal bean or kernel temperature of 95C-160C. The partially defatted cacao solids for edible composition usage have the concentration of total cacao polyphenol of over 20 000 mcg for gram of nonoleaginous cacao solids. The edible composition containing partially defatted cacao solids have the concentration of total cacao polyphenol of over 20 000 mcg for gram of nonoleaginous cacao solids. Chocolate contains at least 3 600 mcg of cacao polyphenol for gram of chocolate. Milk chocolate contains at least 1500 mcg of cacao polyphenol for gram of milk chocolate. Chocolate contains (i) cacao component chosen from partially defatted cacao solids, fully defatted cacao solids, crude cacao, cacao kernels and their mixtures and (ii) at least one fat; and also it contains at least 7 300 mcg of cacao polyphenol for a gram of cacao component. ^ EFFECT: sampling methods of development and processing cacao-beans for cacao components obtaining is provided with increased level of cacao polyphenol; cacao-beans processing method development with substantial quantity of cacao polyphenol that are contained in unprocessed beans is kept in processed beans and cacao components development including cleaned cacao-beans and their parts, crude cacao and partially or fully defatted cacao solids with increased level of cacao polyphenol. ^ 22 cl, 5 dwg, 12 tbl, 31 ex
In this condition, the participant will first have to do a mental imagery exercise where he imagines his best possible self, having accomplished all his big life goals, as vividly as possible. He will then have to think about 4 activities he will plan to do during the next 2 weeks, in line with the imagery exercise. He will then complete a questionnaire about all the activities he identified. He then will proceed to go home and repeat the imagery practice every day for the next two weeks, and do the planned activities. He will report in a booklet ratings of the mental imagery exercise and the activities he did.
The PERSPeCT intervention smokers will receive all components of the Decide2Quit.org web service, but persuasive email messages will be selected by the PERSPeCT recommender system developed in Aim 2. PERSPeCT will use data (see Figure 1) to predict messages that would be most influential to the participant. Intervention smokers will receive one PERSPeCT-generated message per day for 30 days. With each message rating, the PERSPeCT system will further adapt to patient preferences.
The patients in the intervention group will be educated on the proper way to utilize the transcutaneous electrical nerve stimulation (TENS) unit. They will apply the the patches of the TENS unit around the C-section site. Starting 8 hours after C-Section, the TENS unit will be turned on and will remain on until the patient is discharged, to be removed for toilet and showering at the patient's discretion. Once the TENS unit is applied and turned on, the patient will not have to do anything else to maintain the therapy. Routine pharmacologic care will also be available.
In head and neck cancer, areas of tumours with low oxygen supply (called tumour hypoxia) harbour cells that are resistant to radiation and are prone to metastasize. Modern radiotherapy techniques are precise enough to deliver radiation to these small areas and could be used to target these areas to receive higher doses of radiation than the rest of the tumour to overcome resistance. Hypoxia can be "seen" in the body using special imaging such as \[F-18\]-FAZA-PET (\[F-18\]-Fluoroazomycin arabinoside positron emission tomography) but it has not been tested as a method for creating radiation treatment targets. As part of regular pathology tumour tissue is sliced extremely thinly (\<1/100th of a millimeter) and stained so that individual cells can be seen under a microscope. Immunohistochemistry (IHC) is a special type of "stain" that can specifically highlight hypoxic areas. This method is considered the most accurate way to inspect for the presence of hypoxia. There is not a specific staining target for hypoxia ordinarily, but when patients ingest a substance called pimonidazole hydrochloride (HCl) it builds up specifically in hypoxic areas and can be targeted for IHC staining. In this study participants with oral tongue cancer will have a \[F-18\]-FAZA-PET scan and take a single dose of oral pimonidazole-HCl before having surgery to remove their cancer. The whole tumour will be used to create microscope slides using very thin slices of the tumour. The slices will be stained using IHC to show where the pimonidazole has built up and digital scans of the slides will be made. The hypoxia seen on the FAZA-PET scan will be "matched" with hypoxia on the electronic slides to see if the FAZA truly shows where hypoxia is in tumours and if it could be used as a way to plan radiation treatments to deliver more radiation to just those areas.
A professional total health services provider and leader specialized in integrative medicine incorporating data collection tools, analysis tools, and health adjustment procedures. The data collection tools first detect, extract, monitor, and/or receive data from the patient. This data is then provided to the analysis tools according to various integrated medicine methods, from which patient reports with visual diagrams are created and shared with the patient. Each patient's data and relative analysis are individually saved in the respective patient's records and, as a whole, anonymously stored in a database. The anonymous data in this database undergoes comprehensive analysis, utilizing master analysis tools, where the results are employed to produce reliable study reports. Medical facility franchises under the provider send the collected patient data to a central facility for extensive analysis and reporting, after which the appropriate health adjustment procedures are then suggested to and performed on each patient.
Intervention: IPD Device: After randomization the patients in this arm will be subjected to fraxiparine 2850 IE daily and intermittent pressure devices for at least 48 hours or until mobilization. The intermittent pressure device is a leg pump delivered by Converis(R).
A method and apparatus for annotation of medical imagery to facilitate patient identification. diagnosis and treatment is characterized by an imaging device for producing a first signal representative of sensed characteristics of the individual and a minutiae generator which receives the first signal and produces a second signal representative of minutiae of the individual. the minutiae corresponding to specific branch points of blood vessels of the individual. A minutiae data generator analyzes the characteristics of minutiae and produces a third signal representative of the characteristics which is stored in a minutiae database for each of the plurality of known individuals and their medical conditions. The minutiae and minutiae data may be used to annotate medical imagery to facilitate subsequent image comparison byproviding standardized registration points and time-varying characteristics. A minutiae matcher pairs corresponding second signals and third signals from a current patient with those from a database record, and the paired signals are used to align the images and compare them. The minutiae analysis techniques of the invention can be used to identify medical patients, assist in the diagnosis of medical conditions and detect and monitor the use of alcohol and drugs including anesthesia.
Many studies have shown that prior HSV-2 infection is associated with an increased risk for HIV infection. Acyclovir is the most widely studied and clinically utilized antiviral for the suppression of HSV-2 infection. This study will evaluate the efficacy of twice-daily dosing of acyclovir in preventing HIV infection in both WSM and MSM with genital herpes. For this study, WSM will be enrolled in Lusaka, Zambia; Harare, Zimbabwe; and Johannesburg, South Africa; MSM will be enrolled in Lima and Pucallpa, Peru; Seattle, Washington, USA; New York City, New York, USA; and San Francisco, California, USA.

Participants will be enrolled for 12 months in this study and will be randomly assigned to one of two study arms. The first arm will receive 400 mg acyclovir twice daily; the second arm will receive placebo. Follow-up visits will occur monthly. Participants will be tested for STDs, including HIV and syphilis, at each visit and treated as necessary; participants will also be given adherence and condom counseling, risk behavior and sexual history questionnaires, and genital symptoms questionnaires at all study visits. Medical history will be assessed and participants will undergo blood work at Months 3, 6, 9, and 12.
Each physician will receive 50% of their potential incentive based on group performance. Physicians will also receive information on the performance of physicians on key CI measures in their group.
BACKGROUND: Lumbar disc herniation (LDH) is a common spinal disease that can cause severe radicular pain. Massage, also known as Tuina in Chinese, has been indicated to exert an analgesic effect in patients with LDH. Nonetheless, the mechanism underlying this effect of massage on LDH remains unclarified.
METHODS: Forty Sprague-Dawley rats were randomly divided into four groups. A rat LDH model was established by autologous nucleus pulpous (NP) implantation, followed by treatment with or without massage. A toll-like receptor 4 (TLR4) antagonist TAK-242 was administrated to rats for blocking TLR4. Behavioral tests were conducted to examine rat mechanical and thermal sensitivities. Western blotting was employed for determining TLR4 and NLRP3 inflammasome-associated protein levels in the spinal dorsal horn (SDH). Immunofluorescence staining was implemented for estimating the microglial marker Iba-1 expression in rat SDH tissue.
RESULTS: NP implantation induced mechanical allodynia and thermal hyperalgesia in rat ipsilateral hindpaws and activated TLR4/NLRP3 inflammasome signaling transduction in the ipsilateral SDH. Massage therapy or TAK-242 administration relieved NP implantation-triggered pain behaviors in rats. Massage or TAK-242 hindered microglia activation and blocked TLR4/NLRP3 inflammasome activation in ipsilateral SDH of LDH rats.
CONCLUSION: Massage ameliorates LDH-related radicular pain in rats by suppressing microglia activation and TLR4/NLRP3 inflammasome signaling transduction.
PURPOSE: An agent containing an anti-NS5A antibody for preventing and treating hepatitis C virus-mediated liver diseases is provided to suppress replication of hepatitis C virus. CONSTITUTION: An anti-NS5A antibody specifically binds to middle epitope of hepatitis C virus NS5A protein. The antibody is a monoclonal antibody. The N-terminal epitope of NS5A protein is amino acids 66-70. A pharmaceutical composition for preventing and treating hepatitis C virus-mediated liver diseases contains N-terminal epitope of amino acids 60-80; or anti-NS5A antibody which specifically binds to the middle epitope of amino acids 221-236. A method for diagnosing hepatitis type C comprises: a step of preparing a biological sample; a step of contacting an antibody which specifically binds to the middle epitope; a step of quantitating an antibody-antigen complex; and a step of comparing detection result with a normal control group.
BACKGROUND: The most frequent risks of noncommunicable diseases include tobacco use, harmful use of alcohol, unhealthy diet, and physical inactivity. In low-income countries, it is not fully understood how serious these risk factors are. To address the issue at the risk factor level, it is essential to produce evidence that aids in the development of policies and initiatives in the area. This review is aimed to estimate the pooled prevalence of noncommunicable disease behavioral risk factors in Sub-Saharan Africa.
METHODS: Studies published between 2016 and 2023 will be located using searches of the electronic databases PubMed, CINAHL, and African Index Medicus as well as Google and Google Scholar. Two authors will independently review the records, and information will be taken from studies that present statistics on the prevalence of tobacco use, alcohol use, unhealthy diet, and insufficient physical activity among people older than 18 years. Using the I2 and Q statistics, heterogeneity between studies will be evaluated, and it will be investigated using subgroup analyses and meta-regressions. Random effects meta-analysis model will be used and subgroup analysis will be performed by country, study design, and study year.
DISCUSSION: The burden of noncommunicable disease risk factors varies throughout the Sub-Saharan Africa. The review will be essential for both research and policy. The finding may even help to identify settings or subgroups of the population where noncommunicable diseases is of higher concern and help to set prevention priorities, to optimize resource allocation, and guide future research to fill knowledge gaps. The protocol has been registered in PROSPERO (CRD42023431348).
A sunscreen composition includes a metal oxide sunscreen active, an emollient including a benzoate ester, and optionally a humectant, an emulsifier, a film former, and one or more other ingredients. The metal oxide may be present in an amount between about 3.0 wt. % to about 20.0 wt. %, the benzoate ester may be present in an amount between about 5.0 wt. % to about 30.0 wt. %, the humectant may be present in an amount between about 1.0 wt. % to about 20.0 wt. %, the emulsifier may be present in an amount between about 2.0 wt. % to about 10.0 wt. %, the film former may be present in an amount between about 0.1 wt. % to about 5.0 wt. %, and the one or more other ingredients may be present in an amount between about 0.01 to about 45.0, based on the total weight of the composition.
The application was carried out by Graston Technique® (GT®) certified, a therapist with orthopedic rehabilitation and soft tissue treatments for over 12 years. GT® instruments were used to diagnose and treat the damaged soft tissue of gastrocnemius and plantar fascia. The application protocol and the instruments used according to the regions were determined with reference to the GT® manual. GT® treatment can be given to the same region twice a week. A minimum of 2 days break was given between the applications. Gastrocnemius and plantar fascia application completed in 5 minutes in one leg. GT2, GT4 and GT6 instruments used for application.The patient completed the plantar fascia and gastrocnemius stretching exercises right after treatment and also continue at home for 4 weeks, 2 sets per day. Completed 3 repetation for each exercise and stayed in the same position for 30 seconds.
Chronic non-cancer pain is a highly prevalent health issue with personal and societal consequences. Patients suffering from chronic non-cancer pain are mainly cared for by primary care physicians, but research shows that the latter perceive treating chronic pain as difficult. This qualitative descriptive study aimed to explore how primary care physicians in Switzerland manage patients with chronic non-cancer pain and what factors influence patient management. Data were collected through semi-structured interviews amongst primary care physicians in the German speaking part of Switzerland. A thematic analysis of the interviews allowed to identify four main themes: Investigation of chronic pain; patient-provider relationship; patient characteristics, and medical recommendations. These themes were closely interconnected and influenced each other. Physicians not only enquired about the origin of pain but also about the patients' beliefs and expectations towards it. They stressed the role of communication in fostering a good patient-physician relationship and to help patients cope with their pain. In addition to purely medical considerations, the psychological, social and economic situation of their patients and their possible impacts on the management of chronic non-cancer pain played a crucial role when recommending a treatment. This study highlighted the complexity of chronic pain management, which entails that primary care physicians need to figure out a unique strategy for each patient. By integrating patients' values and beliefs, as well as socioeconomic aspects, primary care physicians are in a position to take the lead in chronic non-cancer pain management. However, considering the burden of this disease, more continuous medical education on chronic pain is needed for primary care physicians, especially to better take into account the social determinants of pain.
Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous dose escalation to maintain analgesic effects. The peripheral mu-opioid receptor (MOR) is known to mediate these contradictory effects. Here, we show that the fms-like tyrosine kinase receptor 3 (FLT3) in peripheral somatosensory neurons drives morphine tolerance and hyperalgesia in a male rodent model. We found that chronic morphine treatment increases FLT3 and MOR co-expression, and that inhibiting FLT3 represses MOR-induced hyperactivation of the cyclic adenosine monophosphate (cAMP) signaling pathway, mitigating maladaptive excitatory processes engaged after chronic morphine treatment. Furthermore, in postsurgical or inflammatory models of chronic pain, co-administering morphine with a FLT3-specific inhibitor not only prevents or suppresses tolerance and hyperalgesia but also potentiates the analgesic efficacy of morphine, without aggravating other morphine-induced adverse effects. Our findings suggest that pairing morphine with FLT3 inhibitors could become a promising avenue for chronic pain management to safely harness the power of opioids, without the risk of dose escalation. By enhancing morphine analgesic potency through FLT3 inhibition, this approach could minimize opioid dosage, thereby curtailing the risk of addiction and other opioid-related side effects.
Rash, often with pruritus, and sometimes with fever, arthralgia, and eosinophilia, occurred in about 4 to 7 (depending on renal status and dose) of 100 patients, usually during the first four weeks of therapy. It is usually maculopapular, and rarely urticarial. The rash is usually mild and disappears within a few days of dosage reduction, short-term treatment with an antihistaminic agent, and/or discontinuing therapy; remission may occur even if captopril is continued. Pruritus, without rash, occurs in about 2 of 100 patients. Between 7 and 10 percent of patients with skin rash have shown an eosinophilia and/or positive ANA titers. A reversible associated pemphigoid-like lesion, and photosensitivity, have also been reported.

Flushing or pallor has been reported in 2 to 5 of 1000 patients.
For 6 months (24 weeks), triads of healthy and MCI Black adults aged 55 and over walk 3x/week (1 mile) in Portland's historically Black neighborhoods. Triads follow GPS-mapped routes accessible via the SHARP walking application on a group tablet device. At three points along each route, GPS-triggered "Memory Markers" (historical images of local Black culture and life from1940-2010) appear on the tablet screen serving as a conversational reminisce prompt as the triad walks. At baseline and 24 weeks, cognitive function is measured via the Montreal Cognitive Assessment (MoCA), and weight and blood pressure are measured. Pre-post health surveys rate activity levels, days feeling downhearted/blue, energy level, and health status. Program evaluation surveys at month 1, 3, 6 assess mood, pace and dose of walking, prompt effectiveness, program readiness, and liklihood to recommend program to others. Focus groups at month 1, 3, 6 evaluate participants' program experience and needed changes.
V-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-base homeostasis through H+ secretion in the renal collecting ducts. V-ATPase dysfunction is associated with hereditary distal renal tubular acidosis (dRTA). ATP6V1B1 encodes the B1 subunit of V-ATPase that is integral to ATP hydrolysis and subsequent H+ transport. Patients with pathogenic ATP6V1B1 mutations often exhibit an early onset of sensorineural hearing loss. However, the mechanisms underlying this association remain unclear. We employed morpholino oligonucleotide-mediated knockdown and CRISPR/Cas9 gene editing to generate Atp6v1ba-deficient (atp6v1ba-/-) zebrafish as an ortholog model for ATP6V1B1. The atp6v1ba-/- zebrafish exhibited systemic acidosis and significantly smaller otoliths compared to wild-type siblings. Moreover, deficiency in Atp6v1ba led to degeneration of inner ear hair cells, with ultrastructural changes indicative of autophagy. Our findings indicate a critical role of ATP6V1B1 in regulating lysosomal pH and autophagy in hair cells, and the results provide insights into the pathophysiology of sensorineural hearing loss in dRTA. Furthermore, this study demonstrates that the atp6v1ba-/- zebrafish model is a valuable tool for further investigation into disease mechanisms and potential therapies for acidosis-related hearing impairment.