anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Periodontitis is one of the most common oral diseases, which is characterized by alveolar bone resorption and destruction. In 2010, severe periodontitis (severe periodontitis,SP) had become the sixth largest epidemic disease in the world, affecting 10.8% of the global population or 743 million people . In China, as a major country in the incidence of periodontitis, there is a huge population of patients with severe periodontitis, and the incidence rate is as high as 12.1-16.1% . The fourth National Oral Health Epidemiological Survey also found that the oral health of residents aged 35-44 is generally poor , which has become a major obstacle to the implementation of the "Healthy China 2030" strategy. Previous studies have suggested that the prevalence and severity of periodontal disease increase with age . The possible reasons for this phenomenon are as follows.First, the cumulative effect of attachment level and bone loss with age.Second, changes related to the aging process, such as drug intake, decreased immune function, and changes in nutritional status interact with risk factors can increase the susceptibility to periodontitis. However, recent articles on meta analysis and related epidemiological investigations suggest that the prevalence of severe periodontitis does not increase with age, and the prevalence of SP remains at about 10% even in the elderly. In addition, the global meta analysis with large sample size showed that the prevalence of SP increased sharply between 30 and 40 years old, peaked at about 38 years old. This trend of severe periodontitis with age is not consistent with our traditional cognition, and there is no related research to explain this trend. However, it is found that 30-40 years old patients with severe periodontitis account for a large proportion, so it is of great significance to analyze the risk factors of this group and carry out targeted prevention and control. In order to comprehensively analyze the risk factors of this population, it is inseparable from the analysis of gene polymorphism. Studies related to severe periodontitis gene polymorphism are mainly focused on Toll-like receptor (Toll-likereceptors), interleukin (interleukin,IL), immunoglobulin receptor (Immunoglobulinreceptors), formyl peptide receptor (Formylpeptide receptor), vitamin D receptor (VitaminDreceptor, VDR) and matrix metalloproteinases (matrixmetalloproteinase,MMP). At present, it is considered that the main genes that may be related to the severity of periodontitis are IL-1 α-889, rhIL-talk 1 β + 3953, 6-174, 10-597, CD14-260, CD14-159, MMP1-1607 and so on, which may be related to the severity of periodontitis.
The diet programme will be characterized by carbohydrates (50%),total lipids (30%) and proteins (20%). After calculating the patient's energy need, the amount of calories will be successively adjusted to create an 800 kcal deficit per day.
Chronic kidney disease (CKD) is a progressive and irreversible decline in the function of many nephrons and glomerular filtration rate due to kidney diseases. This decline leads to increased serum levels of urea and creatinine. Patients with CKD often exhibit various oral manifestations, such as an ammonia-like odor, gingival enlargement due to drug therapy, enamel hypoplasia, dental calculus, dry mouth, uremic stomatitis, and oral mucosal lesions. Interestingly, children with CKD tend to have a lower prevalence of dental caries, likely due to the high urea content in their saliva, which has antibacterial properties. CKD is also associated with salivary gland dysfunction and increased oxidative damage. Furthermore, CKD patients have reduced bone quality, making them more susceptible to fractures. A study on the quality of life (QoL) in children with CKD and their parents reported significantly lower physical and social QoL scores in children undergoing hemodialysis compared to healthy controls. This study aims to comparatively evaluate and analyze children diagnosed with different stages of chronic kidney disease (CKD) and healthy children without any systemic conditions, focusing on their age, gender, and oral health habits such as tooth brushing frequency, dental floss usage, and annual dentist visits. Disease-related information such as the stage of CKD, dialysis, and transplantation, as well as oral findings, will be examined using DMFT/dft, ICDAS II, DDE, BAKH, DI, CI, OHI-S, and MGI indices. The study will assess general disease-related quality of life from both the child's and the parent's perspectives using the KINDLR scale. Additionally, salivary samples collected from children with CKD and healthy children will be analyzed for salivary flow rate, pH, buffering capacity, total oxidant and antioxidant capacities, urea, calcium, potassium, and phosphorus levels. Serum urea, calcium, and phosphorus values will also be examined.
<P>PROBLEM TO BE SOLVED: To provide a product having bactericidal effect and healing effect of an ozonized oil while reducing ozone odor.  <P>SOLUTION: Means to incorporate the ozonized oil into soap is used. The soap is produced by an oil/fat saponification method or a fatty acid neutralization method while using a raw material prepared by mixing ozone gas with natural fat and oil 7 including oleic acid and ozonizing the mixture. Alternatively, the soap is produced by using oil and fat, with which ozonized oil is mixed, as a raw material, or the soap containing ozonized oil is produced by mixing the ozonized oil to unsolidified soap during a saponification process or a neutralization process as soap manufacturing processes or after these processes. Furthermore, the soap containing ozonized oil is produced when the ozonized oil is mixed to chip-shaped soap, liquid soap and the like manufactured by an ordinary method.  <P>COPYRIGHT: (C)2009,JPO&INPIT
The bear gall cooling cream is a kind of external medicine for skin disease. It consists of menthol, perpermint oil, camphor, eucalyptus oil, clove oil, cassia bark oil and adjuncts. The characteristic lies in that the beargall is added in, the adjuncts consist of stearic acid, glyceryl monostearate, glycerin, potassium hhdroxide, anti-septic and water. It can heighten the actions of cool and refreshing, expelling heat, keeping cooling head, refreshing oneself, stopping itch and pain. It can also increase the functions of clearing a way heat and toxic material, subducing swelling, stopping pain and curing sore. The water absorbability is good which is beneficial to the medicine-releasing and the skin absorption and makes the dose of medicine relatively decrease. It can mix or absorb the effusion of the surface of the wound and be stimulationless to the skin and easy to clear and wash away.
Clubroot disease caused by the infection of Plasmodiophora brassicae is widespread in China, and significantly reduces the yield of Chinese cabbage (Brassica rapa L. ssp. pekinensis). However, the resistance mechanism of Chinese cabbage against clubroot disease is still unclear. It is important to exploit the key genes that response to early infection of P. brassicae. In this study, it was found that zoospores were firstly invaded hair roots on the 8th day after inoculating with 1 × 107 spores/mL P. brassicae. Transcriptome analysis found that the early interaction between Chinese cabbage and P. brassicae caused the significant expression change of some defense genes, such as NBS-LRRs and pathogenesis-related genes, etc. The above results were verified by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Otherwise, peroxidase (POD) salicylic acid (SA) and jasmonic acid (JA) were also found to be important signal molecules in the resistance to clubroot disease in Chinese cabbage. This study provides important clues for understanding the resistance mechanism of Chinese cabbage against clubroot disease.
Drugs characterized by containing hydroxamic acid derivatives as the active ingredient which are efficacious in treating and/or preventing allergies, in  particular, type I and/or type II allergies, etc. These drugs exert therapeutic and/or preventive effects on inflammation, rhinitis, conjunctivitis, bronchial asthma, atopic dermatitis (dermatitis, enteritis, etc.) and allergic digestive inflammation. Use of these drugs achieves the effects of: (A) inhibiting the proliferation of colonies of blood cells (lymphocytes, etc.) in an affected part; and/or (B) relieving inflammation caused by the migration, infiltration, accumulation, etc. of blood cells (lymphocytes, etc.) into an affected part; and/or (C) regulating the pathophysiological functions of cells such as blood cells (lymphocytes, etc. ), Langerhans cells and dendritic cells; and/or (D) regulating the production o f antibodies, in particular, IgE in the plasma, thus being useful in treating and/or preventing diseases or pathological conditions in the affected parts.
The application provides mycoplasma bovis protein and application thereof. The application provides mycoplasma bovis protein (SBP-2) in mycoplasma bovis lipoprotein family, the gene encoding the protein is P48 gene, and the nucleotide sequence is shown in SEQ ID NO. 1 of the sequence table. The amino acid sequence of the mycoplasma bovis protein SBP-2 is shown as SEQ ID NO. 2. The application adopts a prokaryotic expression technology to construct pET-28a-P48 recombinant plasmid and introduce BL21 escherichia coli, then selects IPTG high-efficiency expression conditions, and utilizes a nickel column affinity chromatography technology to purify SBP-2 protein. The results showed that SBP-2 was a soluble membrane protein with a protein size of 51kDa. Western blot results show that the prokaryotic expression SBP-2 protein has good reactivities. The application provides a mycoplasma bovis vaccine which can excite calves to generate obvious specific immune response and reach high antibody level.
The goal of this American Rhinologic Society expert practice statement (EPS) is to summarize the best available evidence regarding postoperative precautions for patients following endoscopic skull base surgery for intradural pathology. These topics include the administration of postoperative nasal hygiene; patient mobilization and activity level; the resumption of continuous positive airway pressure in patients with obstructive sleep apnea; and the timing and capacity with which a patient may be subjected to barotrauma, such as air travel postoperatively. This EPS was developed following the recommended methodology and approval process as previously outlined. Given the diverse practices and limited agreement on the accepted principles regarding postoperative precautions for patients following skull base surgery, this EPS seeks to summarize the existing literature and provide clinically relevant guidance to bring clarity to these differing practice patterns. Following a modified Delphi approach, four statements were developed, all of which reached consensus. Because of the paucity of literature on these topics, these statements represent a summation of the limited literature and the experts' opinions. These statements and the accompanying evidence are summarized below, along with an assessment of future needs.
A composition which comprises an animal cell population, and which contains immature animal cells. The immature animal cells are characterized by expression of alpha-fetoprotein or lack of essential expression of alpha-fetoprotein and albumin, and at least a portion of said immature animal cells or at least a portion of the progeny of said immature cells is capable of differentiating into cells which express albumin. The cell population is cultured under conditions which result in expansion of the cells. Expansion of the cells may be achieved by culturing the cells in the presence of an extracellular matrix and liver stromal cells; and preferably in the presence of growth factors. Such cells may be used for liver transplantation, artificial livers, and for toxicology and pharmacology studies. Such cells may also be genetically engineered to express proteins or polypeptides of interest.
A remote sensing system for time-of-flight measurements may comprise an array of laser diodes with Bragg reflectors operating in the near-infrared wavelength range synchronized to a detection system comprising lenses, spectral filters and a photodiode array coupled to a processor. The time-of-flight depth information may be combined with various camera imaging systems. The camera system may comprise a lens system, prism and a sensor. In another embodiment, the data from two cameras may be combined with the time-of-flight depth information. Yet another embodiment comprises an imaging system with another array of laser diodes followed by a beam splitter and a detection system. The remote sensing system may be coupled to a smart phone, tablet or wearable device, and the combined data may provide three-dimensional information about at least some part of an object. Also, artificial intelligence may be used in the processing to make decisions regarding the depth and images.
The pathogen Agrobacterium tumefaciens is known for causing crown gall tumours in plants. However, it has also been harnessed as a valuable tool for plant genetic transformation. Apart from the T-DNA, Agrobacterium also delivers at least five virulence proteins into the host plant cells, which are required for an efficient infection. One of these virulence proteins is VirD5. F-box proteins, encoded in the host plant genome or the Ti plasmid, and the ubiquitin/26S proteasome system (UPS) also play an important role in facilitating Agrobacterium infection. Our study identified two Arabidopsis F-box proteins, D5BF1 and D5BF2, that bind VirD5 and facilitate its degradation via the UPS. Additionally, we found that Agrobacterium partially suppresses the expression of D5BF1 and D5BF2. Lastly, stable transformation and tumorigenesis efficiency assays revealed that D5BF1 and D5BF2 negatively regulate the Agrobacterium infection process, showing that the plant F-box proteins and UPS play a role in defending against Agrobacterium infection.
FIELD: chemical and pharmaceutical industry; medicine.SUBSTANCE: present invention relates to the field of chemical and pharmaceutical industry and medicine, namely, to a method for producing an immobilized enzyme preparation based on bromelain, polysaccharides modified with vinyl monomers, and hyaluronic acid. The method includes the dissolution of bromelain in an aqueous solution of low-molecular-weight hyaluronic acid 300 kDa or medium-molecular-weight hyaluronic acid 500 kDa or high-molecular-weight hyaluronic acid 800 kDa in a ratio of 10 mg of bromelain per 2 ml of an aqueous solution of low-molecular-weight hyaluronic acid 300 kDa or medium-molecular-weight hyaluronic acid 500 kDa or high-molecular-weight hyaluronic acid 800 kDa at a concentration of 1.5%. Mixing is carried out until complete dissolving at room temperature. Bromelain is then immobilized by adding to the resulting mixture of a graft copolymer of carboxymethylcellulose 50-100 kDa (CMC) or chitosan 50-100 kDa (CHTS) with N-vinylimidazole (VI) or N,N-dimethylaminoethylmethacrylate (DMAEMA) in an amount of 100 to 290 mg to obtain a liquid preparation or 300 to 500 mg to obtain a gel. Due to the invention, bromelain solutions can be stored at temperatures from 4 to 25ºC for 21 days, and the enzyme becomes more stable in comparison with the native one and it is able to penetrate into the deep layers of the skin. The introduction of modified polysaccharides into the composition of the preparation allows not only to vary the viscosity and consistency of the samples (from the liquid state to the gel with different fluidity), but also promotes the formation of conjugates with an enzyme with a large number of bonds and interactions between the polysaccharide and the enzyme, compared with unmodified carboxymethylcellulose and chitosan. This further increases the stability of the preparation and the concentration of the active substance in the affected area of the skin, and provides a controlled (portion) release of bromelain, maintaining its necessary concentration for a long time.EFFECT: increased stability of the preparation.1 cl, 3 dwg, 1 ex
PURPOSE:To obtain a prolonged release molded pharmaceutical material containing a uniformly mixed chemical, by incorporating a polylactic acid a copolymer thereof with the chemical by the solvent method, molding the resultant mixture, drying the molded material in an inert gas stream at the boiling point of the solvent under ordinary pressure, and drying the dried molded material under reduced pressure and heating. CONSTITUTION:Polyactic acid or a copolymer thereof is adjusted with a solvent to 3- 30wt% concentration, and then chemical powder is added and incorporated therewith and molded into a filmlike or sheetlike pharmaceutical material, which is then dried in an inert gas stream at the boiling point of the solvent or below under ordinary pressure and dried under reduced pressure and heating to remove completely the solvent. Thus, the titled prolonged release pharmaceutical material containing the polyactic acid or copolymer thereof as a base material is obtained. A halogenated aliphatic hydrocarbon, e.g. methylene chloride or chloroform, is preferred for the solvent. The chemical is uniformly incorporated with the solvent by the simple molding process without the residual solvent nor air bubble in the molded material.
The utility model discloses an oral insulin particle. The utility model uses the traditional Chinese medicine dragon's blood as a carrier, and uses a micro solid particle of the insulin as a core; the core is embedded in the carrier to form a nanometer insulin microsphere, and the average diameter of the nanometer insulin microspheres is smaller than 80 nanometer. Because the core (the micro solid particle) of the insulin is embedded in the carrier (the traditional Chinese medicine dragon's blood), when the utility model is taken orally, the core (the micro solid particle of the insulin is not directly contacted with buccal liquifying enzyme or gastrointestinal digestive enzyme, and the activity of the insulin can not be disturbed. After taken, the micro particle of the insulin can be directly absorbed by intestinal villi in intestinal tract, and can join blood circulation. In the process of degradation and absorption, the insulin becomes steady and begins to release slowly, the medicine comprises both western medicine and traditional Chinese medicine, and the utility model is the mixture of the two. The western medicine and the traditional Chinese medicine are matched with each other, and the disease can be completely cured. The utility model is convenient to take, and is an ideal medicine for curing diabetes.
PURPOSE: The purpose of this cadaver study was to examine the surface morphology of the osteochondral grafts harvested from the femoral condyles using the free-hand graft harvesting technique.
MATERIALS AND METHODS: One hundred osteochondral grafts were harvested with 6.5 mm chisels at ten different donor sites using the free-hand technique in five paired knee specimens (Mean age: 56.4 years). The cartilage and subchondral bone surface angles were measured through multiplanar reconstruction computerized tomography examination. The cartilage thickness was measured with a MicroScribe G2X digitizer with an accuracy of 0.02 mm. An acceptable congruity could be obtained when these plugs were transferred to a perpendicular socket (articular step-off of less than 1 mm and 0.5 mm) was evaluated.
RESULTS: Four plugs were damaged or broken during harvesting due to technical difficulties; thus remaining 96 plugs were analyzed. The cartilage thickness varied between 1.36 mm and 3.26 mm across the donor sites. The cartilage was the thinnest in the medial intercondylar notch and thickest in the lateral supracondylar notch. Twenty of ninety-six plugs (20.8%) had unacceptable cartilage surface inclination according to the > 0.5 mm protrusion criteria. Of these plugs, 14 were harvested from the lateral intercondylar notch, whereas five of 96 plugs (5.2%) had unacceptable cartilage surface inclination according to the > 1 mm protrusion criteria. Of these plugs, all were harvested from the lateral intercondylar notch.
CONCLUSIONS: High rates of unacceptable plugs (up to 100%) might be harvested from the lateral intercondylar notch. In large chondral lesions that require multiple plugs, lateral and medial supracondylar ridges were the best donor sites for perpendicular plug harvesting, whereas lateral intercondylar notch should be avoided.
OBJECTIVE: The purpose of study was to report the subjective and objective results of different methods of surgical treatment of cystocele using the transvaginal Mesh-system.
METHODOLOGY: A prospective study was conducted from January 2017 to December 2020 comparing anterior colporrhaphy with vaginal mesh and two distinct types of vaginal wall repair sutures in the surgical treatment of cystocele. The primary endpoint was the incidence rate of vaginal wall erosion complications 12 months after surgery. Secondary endpoints were anatomic outcomes, TVM-related morbidity, and patient satisfaction measured using validated questionnaires.
RESULTS: In total, 102 patients with stage III-IV cystocele and the average age of 67.2 ± 3.1 years (age range of 47-79 years old) took part in the study. Of the 102 women initially enrolled, 102 (100%) were successfully followed up 12 months after primary surgery. The primary result, the objective erosion development, was radically different in the comparison groups (1.6% against 23.5%, respectively). Analysis of the improved method of operative treatment showed a prominent level of positive, uncomplicated, surgery results of 98.4% (60/61). The anatomic success rate of recovery from cystocele was 99.9% (101/102) 12 months after surgery.
CONCLUSION: The suggested method of restoring the anterior vaginal wall in stage III-IV isolated cystocele without signs of incomplete and complete prolapse of the uterus showed a radically positive result. The number of complications was relatively high in the comparison group, but no difference was observed in satisfaction with the anatomical results of the surgery. The percentage of the vaginal wall erosion when using a single-layer suture is 23.5%, when using a two-layer suture is 1.6.
The present invention discloses a method for extracting metal sulfur proteins from pork livers, which relates to an extraction method of metal sulfur proteins. The present invention more specifically relates to a method for extracting metal sulfur proteins from pork livers. Anthony pigs are used as donors of the present invention. The method comprises: trace element zinc is injected into the abdomen cavities of the anthony pigs for induction, the anthony pigs are slaughtered after five times of induction; a kind of metal sulfur proteins with good stability and high purity are separated and extracted from pork livers; the yield of the metal sulfur proteins is 2 to 3 times of that of metal sulfur proteins extracted from rabbit bodies. The metal sulfur proteins of pork livers induced by zinc have the advantages of low cost, good effect, high yield, wide source of inductive agents, no side effect, etc. Moreover, pigs are a kind of animals fed universally, and have wide sources. After metal sulfur proteins are induced and extracted, pork can be eaten normally. The product of the present invention is suitable for the antioxidation of fowl feed and the stress resistant effect of fowl.