anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Melanoma is a type of tumor skin with high metastatic potential. Reconstructed human skin, development for pre-clinic assay, are make using primary human cells, but with same limitations. The aim this study was to characterize a cell culture model, with structure similar to human skin containing melanoma cells entirely from cell lines. Reconstructed skin with melanoma were development using human fibroblasts (MRC5), human epidermal keratinocytes (HaCat), and human melanoma (SK-MEL-28) embedded in collagen type I. The structure was characterized by hematoxylin-eosin stained, as well as points of melanoma cell invasion, which was associated with activity of MMPs (MMP-2 and MMP-9) by zymographic method. Then, the gene expression of the target molecular mechanisms involved in melanoma progression were evaluated. Here, the model development showed a region epidermis organized and separated from the dermis, with fibroblast cells confined and melanoma cells form delimited area invasion. MMP-2 and MMP-9 were identified during of cell culture and gene expression of BRAF, NRAS, and Vimentin was confirmed. The proposed model provides one more opportunity to study in vitro tumor biology of melanoma and also to allows the study of new drugs with more reliable results then whats we would find in vivo.
We conducted a pilot prospective multicenter study in five French centers (Strasbourg University Hospital, Strasbourg Sainte Anne Hospital, Colmar, Mulhouse, Valenciennes) designed to evaluate the feasibility and effects of a 3 month treatment regimen with rapid-acting insulin and basal long-acting insulin analogues (i.e., aspart and detemir, respectively) along with CGM on glucose level control in diabetic hemodialyzed patients.

All patients who were admitted to the nephrology departments and matched the inclusion criteria between January 1st, 2010, and June 30th, 2012, were consecutively included in the study. CGM was used to analyze blood glucose excursions at baseline and 1 and 3 months of treatment. It was started during the first dialysis session and then continued for the next two days at home under ambulatory conditions. The CGM was continued during the next dialysis session. Therefore, in total, CGM (Navigator®; Abbott, Rungis, France) was performed for 54 hours, including two consecutive hemodialysis sessions and at 0, 1, and 3 months of treatment. The probe for the system was subcutaneously inserted at the beginning of the first dialysis session to analyze interstitial glucose, and it was removed at the end of the second dialysis session. Due to the time required for CGM calibration, plasma glucose levels were only partially recorded during the first dialysis session.
PURPOSE:A drug, containing sialosylcholesterol as an active ingredient and useful for treating various diseases caused by disorder in peripheral nervous or central nervous systems. CONSTITUTION:A remedy containing sialosylcholesterol expressed by formulas I and II as an active ingredient. Most of the diseases caused by disorder in nervous systems are intractable and there are few kinds of treating drugs therefor. Although cobalamin (common name) is typical at present, the effect thereof is insufficient yet. As a result of a test on activity thereof in cultivation of neuroblastomatous cells (Neuro 2a) derived from mice using the sialosylcholesterol, action of promoting growth of neurites is recognized. Thereby the sialosylcholesterol is useful as a remedy for neuropathy and is capable of increasing water solubility by converting into Na silate and used in the form of eye drip, inhalant, intravenous injection, intramuscular injection or subcutaneous injection.
Sound localization is essential to perceive the surrounding world and to interact with objects. This ability can be learned across time, and multisensory and motor cues play a crucial role in the learning process. A recent study demonstrated that when training localization skills, reaching to the sound source to determine its position reduced localization errors faster and to a greater extent as compared to just naming sources' positions, despite the fact that in both tasks, participants received the same feedback about the correct position of sound sources in case of wrong response. However, it remains to establish which features have made reaching to sound more effective as compared to naming. In the present study, we introduced a further condition in which the hand is the effector providing the response, but without it reaching toward the space occupied by the target source: the pointing condition. We tested three groups of participants (naming, pointing, and reaching groups) each while performing a sound localization task in normal and altered listening situations (i.e. mild-moderate unilateral hearing loss) simulated through auditory virtual reality technology. The experiment comprised four blocks: during the first and the last block, participants were tested in normal listening condition, while during the second and the third in altered listening condition. We measured their performance, their subjective judgments (e.g. effort), and their head-related behavior (through kinematic tracking). First, people's performance decreased when exposed to asymmetrical mild-moderate hearing impairment, more specifically on the ipsilateral side and for the pointing group. Second, we documented that all groups decreased their localization errors across altered listening blocks, but the extent of this reduction was higher for reaching and pointing as compared to the naming group. Crucially, the reaching group leads to a greater error reduction for the side where the listening alteration was applied. Furthermore, we documented that, across blocks, reaching and pointing groups increased the implementation of head motor behavior during the task (i.e., they increased approaching head movements toward the space of the sound) more than naming. Third, while performance in the unaltered blocks (first and last) was comparable, only the reaching group continued to exhibit a head behavior similar to those developed during the altered blocks (second and third), corroborating the previous observed relationship between the reaching to sounds task and head movements. In conclusion, this study further demonstrated the effectiveness of reaching to sounds as compared to pointing and naming in the learning processes. This effect could be related both to the process of implementing goal-directed motor actions and to the role of reaching actions in fostering the implementation of head-related motor strategies.
Our objective was to systematically examine the characteristics of exercise interventions on adherence and dropout in children and adolescents with obesity. PubMed, Embase, PsycINFO, Lilacs, Scielo, and The Cochrane Central Register of Controlled Trials and reference lists of relevant articles were searched. We included randomized controlled trials with exercise interventions for pediatric patients with obesity presenting data on dropout and/or adherence. Two reviewers screened the records independently for eligibility with disagreements being resolved by a third reviewer. Twenty-seven studies with 1268 participants were included. Because of high heterogeneity and poor reporting of adherence, it was not possible to perform a meta-analysis. Dropout prevalence was calculated, and subgroup analyses comparing different types of exercise and a meta-regression with potential moderators were performed. We found a dropout rate of 13%. Subgroup analyses did not identify significant differences. The duration of the exercise presented a moderating effect on dropout, suggesting that longer exercise sessions may lead to higher dropout in children and adolescents with obesity. Because of the poor adherence data, it is not clear which exercise characteristics may moderate adherence. To improve the quality of childhood obesity care, it is mandatory that future studies present adherence data. Systematic review registration: PROSPERO CRD42021290700.
BACKGROUND: Immune cell metabolism governs the outcome of immune responses and contributes to the development of autoimmunity by controlling lymphocyte pathogenic potential. In this study, we evaluated the metabolic profile of myelin-specific murine encephalitogenic T cells, to identify novel therapeutic targets for autoimmune neuroinflammation.
METHODS: We performed metabolomics analysis on actively-proliferating encephalitogenic T cells to study their overall metabolic profile in comparison to resting T cells. Metabolomics, phosphoproteomics, in vitro functional assays, and in vivo studies in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), were then implemented to evaluate the effect of metabolic targeting on autoreactive T cell pathogenicity. Finally, we confirmed the translational potential of our targeting approach in human pro-inflammatory T helper cell subsets and in T cells from MS patients.
RESULTS: We found that autoreactive encephalitogenic T cells display an altered coenzyme A (CoA) synthesis pathway, compared to resting T cells. CoA fueling with the CoA precursor pantethine (PTTH) affected essential immune-related processes of myelin-specific T cells, such as cell proliferation, cytokine production, and cell adhesion, both in vitro and in vivo. Accordingly, pre-clinical treatment with PTTH before disease onset inhibited the development of EAE by limiting T cell pro-inflammatory potential in vivo. Importantly, PTTH also significantly ameliorated the disease course when administered after disease onset in a therapeutic setting. Finally, PTTH reduced pro-inflammatory cytokine production by human T helper 1 (Th1) and Th17 cells and by T cells from MS patients, confirming its translational potential.
CONCLUSION: Our data demonstrate that CoA fueling with PTTH in pro-inflammatory and autoreactive T cells may represent a novel therapeutic approach for the treatment of autoimmune neuroinflammation.
The invention relates to commodity, in particular to a black mud beautification perfumed soap. The invention is prepared with the following raw materials according to the weight ratio: perfumed soap base metal is 60 to 80, glycerine is 1 to 5, black mud is 1 to 10, pearl powder is 1 to 2, furnace dust is 1 to 2, honeysuckle flower is 1 to 2 and dittany bark is 1 to 2. Compared with the prior art, the invention has the remarkable advantages that the selected materials of the perfumed soap is scientific and exquisite, the Chinese traditional medicine components of the pearl powder, aloe, the dittany bark, and the honeysuckle flower has the functions of beautifying and nourishing face, toxin cleaning and toxin expelling, the black mud can balance the secretion of the skin fat, to ensure the skin metabolism to take to in virtuous circles. The invention can clean the skin, and simultaneously also can achieve the purposes of balancing the secretion of the skin fat and nourishing the skin. The invention has good integrated matching performance, has no secondary effect, does not affect the skin, is clean, nourishes and moistens the skin, removes wrinkle and eliminates toxicant, has good skin nourishing and caring effects, good health protection effect, and is particularly suitable for the dry and cold season or region. The preparation method is simple, the implementation is easy, and the product performance can be ensured.
The present invention relates to an ultrasound stimulator attachable to a human body. The ultrasound stimulator transmits ultrasound waves and vibration to tissue of a human body to provide therapeutic and esthetic effects. Moreover, the ultrasound stimulator can be attached to a human body and can be closely attached to skin in an area of a human body having a three-dimensional curved surface. Therefore, the ultrasound stimulator can increase the therapeutic effect. The ultrasound stimulator is attached to skin of a human body and transmits ultrasound stimuli. The ultrasound stimulator comprises: a body (100) that is made of a soft material and includes an inner space (110) for generating negative pressure by compression and a cupping-type close contact piece (120) for making close contact on a skin contact surface by air; a pad (200) which is fixated on a lower portion of the inner space (110) of the body (100), emits ultrasound, and is made of a silicone material; and a piezoelectric element (300) built in an upper portion of the pad (200).
An artificial skin is prepared by impregnating a collagen matrix with a transforming growth factor- beta  having a collagen-binding site to bind the growth factor to the collagen matrix, incubating the impregnated matrix with a source of fibroblasts and mesenchymal stem cells to form a captured population of mesenchymal stem cells within the impregnated matrix and incubating the resultant matrix with a source of keratinocytes which epithelialize the matrix to form an artificial skin. The collagen matrix is preferably in the form of a collagen sheet. The transforming growth factor- beta  can be transforming growth factor- beta 1, transforming growth factor- beta 2 or transforming growth factor- beta 3. Preferably, the transforming growth factor- beta  having a collagen binding site is a fusion protein having a purification tag, at least one proteinase site, an extracellular matrix binding site and a transforming growth factor active fragment. The extracellular matrix binding site binds collagen, fibronectin or a cell surface. A method of preparing the fusion protein involves purifying and renaturing transforming growth factor- beta  protein to provide an active fusion protein.
Understanding mortality causes is important for the conservation of endangered species, especially in small and isolated populations inhabiting anthropized landscapes where both natural and human-caused mortality may hinder the conservation of these species. We investigated the mortality causes of 53 free-ranging brown bears (Ursus arctos) found dead between 1998 and 2023 in the Cantabrian Mountains (northwestern Spain), a highly human-modified region where bears are currently recovering after being critically threatened in the last century. We detected natural traumatic injuries in 52.63% and infectious diseases in 39.47% of the 38 bears for which the mortality causes were registered, with 21.05% of these cases presenting signs of both infectious diseases and traumas. More specifically, almost 30% of the bears died during or after intraspecific fights, including sexually selected infanticide (10.53%). In addition, primary infectious diseases such as infectious canine hepatitis, distemper, clostridiosis and colibacillosis caused the death of 15.79% of the bears. The number of direct human-caused deaths (i.e., shooting, poisoning, snare) decreased over the study period. This study also reveals three new mortality causes triggered by pathogens, two of which-Clostridium novyi and verotoxigenic Escherichia coli-not previously described in ursids, and the other one, canine distemper virus, never reported in brown bears as cause of death. New management strategies for the conservation of Cantabrian bears, which are urgently needed due to the rapid expansion of the population, should consider the mortality causes described in this study and must promote further research to elucidate how the high prevalence of infectious diseases may threaten the current recovery of the population.
NEW MATERIAL:A guanidinoethanethiosulfonic acid expressed by the formula. USE:With cholesterol lowering and high density lipoprotein (HDL)-cholesterol lowering action and useful as an antiarteriosclerotic and anticholesterol agent. PREPARATION:Guanidinoethanethiosulfonic acid is reacted with sulfur in the presence of a base, e.g. sodium hydroxide, to afford the aimed compound expressed by the formula. Powdery sulfur is preferably used as the sulfur and an alcohol, particularly lower alcohol, e.g. methyl alcohol, is preferably used as the solvent.
A method and apparatus for providing visual feedback to a user during a personal binding activity. A target area on a user's body where a personal binding operation is being performed is tracked. The progress of the personal binding activity of the user is monitored. At least one item of feedback relating to the user's personal binding activity is determined, and a relevant location on the user's body for visually projecting information representative of the item of feedback is determined. Feedback information is projected onto the relevant position of the user's body, which feedback information is observable by the user in a mirror. Because the user is focusing on the personal device activity by gazing at a target area of the body with a mirror, the feedback information will automatically coincide with the user's gaze direction, also focusing on the user's eyes. The dynamic occlusion function may track the user's eyes, ensuring that the light projection is performed without aligning the user's eyes.
OIS is very similar to conventional interrupted intradermal suture (IS), except that the suture in OIS is canted or angled relative to the vertical plane (Figure 1). To perform OIS, the needle is passed from deep to superficial dermis and canted 30°-60° from the normal vertical plane. The needle is then inserted into the opposite wound edge from superficial to deep dermis in a mirror-image fashion. The thread is tied with a square knot to finish the suture.
Consecutive women attending subfertility clinic at Queen Mary Hospital, University of Hong Kong who are scheduled for IVF treatment will be recruited. Women who have normal uterine cavity will be randomized into study and control groups in 1 to 1 ratio according to a computer-generated randomization list. Patients will be stratified according to the first or repeated cycle.

For patients in the study group, in the cycle immediately preceding the scheduled IVF treatment, LH surge will be determined by daily serum LH level starting from 18 days before the next expected period. LH surge is defined as an elevation of LH to 2 times the level of the average of the previous 3 days and the absolute level of the LH should be more than or equal to 20 IU/L. Women randomized into the study group will have endometrial biopsy performed by pipelle 7 days after the LH surge (LH+7) and they will be instructed to use non-hormonal means of contraception during that cycle. All patients will then proceed to IVF treatment in the next cycle as scheduled. They will receive standard ovarian stimulation according to the departmental protocol and have a maximum of two embryos replaced 2 days after the oocyte retrieval. On-going pregnancy rates between the two groups will be compared.
BACKGROUND: The proliferation antigen Ki-67 has been widely used in clinical settings for cancer staging for many years, but investigations on its biological functions have lagged. Recently, Ki-67 has been shown to regulate both the composition of the chromosome periphery and chromosome behaviour in mitosis as well as to play a role in heterochromatin organisation and gene transcription. However, how the different roles for Ki-67 across the cell cycle are regulated and coordinated remain poorly understood. The progress towards understanding Ki-67 function have been limited by the tools available to deplete the protein, coupled to its abundance and fluctuation during the cell cycle.
RESULTS: Here, we use a doxycycline-inducible E3 ligase together with an auxin-inducible degron tag to achieve a rapid, acute and homogeneous degradation of Ki-67 in HCT116 cells. This system, coupled with APEX2 proteomics and phospho-proteomics approaches, allows us to show that Ki-67 plays a role during DNA replication. In its absence, DNA replication is severely delayed, the replication machinery is unloaded, causing DNA damage that is not sensed by the canonical pathways and dependent on HUWE1 ligase. This leads to defects in replication and sister chromatids cohesion, but it also triggers an interferon response mediated by the cGAS/STING pathway in all the cell lines tested.
CONCLUSIONS: We unveil a new function of Ki-67 in DNA replication and genome maintenance that is independent of its previously known role in mitosis and gene regulation.
The present invention discloses a rhizoma gastrodiae beverage and a production method. The beverage contains Chinese herbal medicine ingredients. The Chinese herbal medicine in 1 kilogram of beverage is prepared from the components of the following proportion by weight: 3 to 10g of rhizoma gastrodiae, 3 to 10g of red sage root, 2 to 7g of hawthorn fruit, 1 to 5g of Chinese date, 1 to 5g of flos lonicera, 150 to 250g of sucrose, 300 to 700g of glutinous rice and 18 to 22g of Xiaoqu. The preparing method of the rhizoma gastrodiae beverage in the preparation claim 1 is characterized in comprising the following procedures: materials preparation, material immersion, material evaporation, addition of Xiaoqu, fermentation, water addition, filtration and flavouring to prepare a finished product. The rhizoma gastrodiae beverage is a biologic fermentative health-care beverage of natural medicine, and has the advantages of red color, sweet and acidulous taste and fragrant, soft and pure mouth feel. The rhizoma gastrodiae beverage is characterized in that the rhizoma gastrodiae beverage is prepared from pure natural Chinese herbal medicine to form an agent without any chemical additive, essence and pigment, and the glutinous rice is used as materials to brew a multifunctional beverage which is suitable for people taste and the requirement of the function of a human body and has the functions of thirst quenching, nutrition, disease prevention and the strengthening of the immunity of the human body by microorganism fermentation. The rhizoma gastrodiae beverage is suitable for the young and the old, and has no limitation in winter and summer; after being cooled and heated, the rhizoma gastrodiae beverage can be drunk by opening.
The invention discloses a hybridoma cell line for secreting foot-and-mouth disease virus shared monoclonal antibody 10B10 and application thereof. The invention firstly discloses a hybridoma cell line for secreting foot-and-mouth disease virus shared monoclonal antibody 10B10, and the microorganism preservation number is CGMCC No. 13841. The invention further discloses a foot-and-mouth disease virus shared monoclonal antibody 10B10 secreted by the hybridoma cell line. Indirect immunofluorescence detection shows that the monoclonal antibody 10B10 is a serotype shared monoclonal antibody, and the serotype shared monoclonal antibody and O, A and Asia1 type foot-and-mouth disease viruses are in specific reaction. The monoclonal antibody 10B10 of the invention is used as a detection antibody, and can be used for the specific detection of A, O and Asia1 type foot-and-mouth disease virus antigen or antibody. The foot-and-mouth disease virus shared monoclonal antibody 10B10 and the hybridoma cell line thereof have application prospects in diagnosis or prevention of foot-and-mouth disease.
Administer the first dose of HepaGam B during the grafting of the transplanted liver (the anhepatic phase) with subsequent dosing as recommended in Table 1. 

Calculate the dosing from the measured potency of the particular lot of HepaGam B as stamped on the vial label.

Administer by intravenous infusion (Table 2).

HepaGam B dose adjustments may be required in patients who fail to reach anti-HBs levels of 500 International Units per liter within the first week post-liver transplantation1. Patients who have surgical bleeding or abdominal fluid drainage (greater than 500 milliliters) or patients who undergo plasmapheresis are particularly susceptible to extensive loss of circulated anti-HBs. In these cases, the dosing regimen should be increased to a half-dose (10,000 International Units calculated from the measured potency as stamped on the vial label) intravenously every 6 hours until the target anti-HBs is reached.