anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To provide a tissue transfer method for reconstruction and augmentation of soft tissue.SOLUTION: With a method according to the present invention, adipose tissue is harvested from a patient. The harvested tissue is processed using a centrifugal machine 244 to isolate a purified subset 250 of the adipose tissue, with the processing including separation and removal of a substantial amount of triglycerides from the harvested adipose tissue. The centrifugation may be performed to cause separation of water from the purified adipose tissue 250 and to cause separation of oil from mature adipocytes. Specifically, a spin rate may be selected to be high enough to cause lesions in the mature adipocytes that results in release of the oil. The method continues to implantation of the purified adipose tissue 250 into the patient at a breast or another area identified for reconstruction or augmentation. The implantation is performed based on an injection pathway model that defines injection point locations and a plurality of injection pathway directions from each point.
Depressive disorders are the most prevalent mental health conditions in the world. The commonly prescribed antidepressant medications can have serious side effects, and their efficacy varies widely. Thus, simple, effective adjunct therapies are needed. Vinegar, a fermented acetic acid solution, is emerging as a healthful dietary supplement linked to favorable outcomes for blood glucose management, heart disease risk, and adiposity reduction, and a recent report suggests vinegar may improve symptoms of depression. This randomized controlled study examined the 4-week change in scores for the Center for Epidemiological Studies Depression (CES-D) questionnaire and the Patient Health Questionnaire (PHQ-9) in healthy overweight adults ingesting 2.95 g acetic acid (4 tablespoons vinegar) vs. 0.025 g acetic acid (one vinegar pill) daily. A secondary objective explored possible underlying mechanisms using metabolomics analyses. At week 4, mean CES-D scores fell 26% and 5% for VIN and CON participants respectively, a non-significant difference between groups, and mean PHQ-9 scores fell 42% and 18% for VIN and CON participants (p = 0.036). Metabolomics analyses revealed increased nicotinamide concentrations and upregulation of the NAD+ salvage pathway for VIN participants compared to controls, metabolic alterations previously linked to improved mood. Thus, daily vinegar ingestion over four weeks improved self-reported depression symptomology in healthy overweight adults, and enhancements in niacin metabolism may factor into this improvement.
PURPOSE:To obtain the subject tablet controlling the release of a medicine by blending a specified amount of water-soluble polymer and water-insoluble polymer and coating the blended polymer mixture to a constant thickness. CONSTITUTION:A composition obtained by blending a water soluble polymer (e.g. polyethylene glycol) with a water-insoluble polymer (e.g. ethylcellulose) in an amount of equivalent-3 times weight based on the former polymer is coated. Coating is carried out in a solvent such as ethanol at 40-70 deg.C using a spray coater so that the coating thickness may be 100-1000mum. The coated material is subjected to preparation into a tablet, thus obtaining the objective material. As for the strength of the tablet, the wet strength directly after 12hr' dissolution test is preferably >=0.2kg and releasing time of the medicine is preferably 4-18hr. The resultant tablet has a high strength enough to resist against mechanical stress due to motions, etc., of the digestive tube and can be applied for a sustainingly releasable fertilizer, agricultural chemical, bath agent, etc.
Has tested negative for SARS-CoV-2 within appropriate timeframe (criteria vary for different study stages, and in phase 2 part 1, 2 and 4 enrolment may be accepted using symptoms-based criteria). Aged 16 years or older, willing and able to provide informed consent.
Participants received 5 intramuscular injections of AGN-151586 in the glabellar complex on Day 1. Based on meeting the retreatment criteria, participants may also have received 1 open-label treatment of AGN-151586 on Day 43.
Moderate-intensity continuous training consists of periods followed by 50 minutes of exercise - bicycling, running, jogging, marching, paddling, etc. - at a recorded frequency of 70-75 percent maximal heart rate.
The invention belongs to the technical field of antiviral drugs, and particularly relates to application of CNPY3 protein as a target for treating dengue fever. The invention discloses and identifies an important host protein CNPY3 related to dengue virus infection. The host gene is significantly down-regulated in dengue patient blood and in dengue virus infected dendritic cells and THP-1 cells. Its expression is negatively correlated with dengue disease progression and positively correlated with the expression of most Toll-like receptors. Further studies indicate that down-regulation of this gene in THP-1 cells inhibits IFN- β production and ISGs gene expression, promoting infection with DENV-2. And the expression of the gene is up-regulated in Vero and HEK293T cells, so that the infection of DENV-2 can be inhibited. These results indicate that CNPY3 is involved in the innate immune response signaling pathway, has an anti-dengue virus effect, and is a potential therapeutic target for dengue.
PURPOSE: To create a preference-based value set scoring system for the MobQoL-7D outcome measure, and to examine differences in the health state preferences of the general population and individuals with impaired mobility.
METHODS AND MATERIALS: A preference elicitation study was undertaken to ascribe utility weights to all health states (i.e., all unique combination of answers) described by the MobQoL-7D. The elicitation exercise was developed using the Online Elicitation of Personal Utility Functions (OPUF) tool. Two UK sample groups were recruited; firstly a representative general population sample (N = 504), secondly a balanced sample of individuals with impaired mobility (N = 368). Distinct preference-based value sets were developed for each sample. Differences in dimension ranking, weighting, and overall utility values were assessed.
RESULTS: The general population sample considered most health states, especially the more severe states, to be worse than the mobility impaired sample comparatively. Statistically significant differences between the samples were observed in four of the seven MobQoL-7D dimensions.
CONCLUSIONS: This study is the first to provide preference-based value sets for the MobQoL-7D, ready for use in economic evaluations, QALY calculation, and other clinical or research applications. The study demonstrates how the general public and individuals with impaired mobility value health states differently.
Subjects with iEEG electrodes implanted will perform an eye-tracking memory task in which they view arrays of everyday objects arranged as a grid and later undergo memory testing for these object image arrays. Half of the object-image arrays are studied actively (subjects view objects in any order they wish) and half are studied passively (viewing patterns are predetermined and subjects must follow along). For the memory test, subjects attempt to pick studied objects from among novel (foil) objects and replace them at studied locations using the computer mouse. Eye movements will be remotely (noninvasively) tracked using a camera during the study phases. This memory task will take about 1.5 hours to complete. 20 subjects undergoing iEEG recordings as part of epilepsy treatment will be assigned to this study experiment condition.
Actin is a globular protein present in every cell with a 42 kilodalton molecular mass. It plays an important role in muscle contraction while being an essential component of the cytoskeleton as well. Several proteins (e.g. gelsolin, Gc-globulin) bind actin in the circulation during the physiological cell turnover, thus making its urinary appearance unlikely. However, recent studies indicate that actin could be detected in the urine of kidney-transplant patients with acute kidney injury. Therefore, the main focus of our research was the detection and measurement of actin in the blood and urine in patients with sepsis or sepsis-related acute kidney injury, as the early recognition of kidney injury - especially in sepsis - is essential in the aspect of therapy and survival.
Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a  beta -blocker are provided, wherein the  beta -blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
BACKGROUND: A history of SARS-CoV-2 infection has been reported to be associated with an increased risk of postoperative pulmonary complications (PPCs). Even mild PPCs can elevate the rates of early postoperative mortality, intensive care unit (ICU) admission and prolong the length of ICU and/or hospital stays. Consequently, it is crucial to develop perioperative management strategies that can mitigate these increased risks in surgical patients who have recently been infected with SARS-CoV-2. Accumulating evidence suggests that nitric oxide (NO) inhalation might be effective in treating COVID-19. NO functions in COVID-19 by promoting vasodilation, anticoagulation, anti-inflammatory and antiviral effects. Therefore, our study hypothesises that the perioperative use of NO can effectively reduce PPCs in patients with recent SARS-CoV-2 infection.
METHOD AND ANALYSIS: A prospective, double-blind, single-centre, randomised controlled trial is proposed. The trial aims to include participants who are planning to undergo surgery with general anaesthesia and have been recently infected with SARS-CoV-2 (within 7 weeks). Stratified allocation of eligible patients will be performed at a 1:1 ratio based on the predicted risk of PPCs using the Assess Respiratory Risk in Surgical Patients in Catalonia risk index and the time interval between infection and surgery.The primary outcome of the study will be the presence of PPCs within the first 7 days following surgery, including respiratory infection, respiratory failure, pleural effusion, atelectasis, pneumothorax, bronchospasm and aspiration pneumonitis. The primary outcome will be reported as counts (percentage) and will be compared using a two-proportion χ2 test. The common effect across all primary components will be estimated using a multiple generalised linear model.
ETHICS AND DISSEMINATION: The trial is approved by the Institutional Review Board of Xijing Hospital (KY20232058-F1). The findings, including positive, negative and inconclusive results, will be published in scientific journals with peer-review processes.
TRIAL REGISTRATION NUMBER: NCT05721144.
Chronic testicular pain (CTP) is testicular pain that persists for more than 3 months, and the cause of the pain is often unknown, sometimes requiring differentiation from varicocele (VC). In this study, the shortform McGill pain questionnaire (SF-MPQ), which allows a detailed assessment of pain, was used to examine the clinical differences between CTP and scrotal pain due to VC. A retrospective study (IRB# : TeiRin21- 036) was conducted on 77 patients who visited our clinic between 2018 and 2022 with the chief complaint of scrotal pain. Of the 77 patients, 19 were diagnosed with CTP and 58 patients with VC. All patients were evaluated for marital status, smoking, alcohol consumption, body mass index, and duration of pain. In addition, comorbidities were assessed using the Charlson Comorbidity Index (CCI). All patients were asked to complete the Numerical Rating Scale (NRS), Verbal Rating Scale (VRS), and SF-MPQ. With respect to the patient background, the CTP group was significantly older than the VC group, had a higher percentage of married patients, and had higher CCI. Concerning pain assessment, the CTP group had significantly higher NRS and VRS than the VC group. In terms of pain sensation and character, the CTP group experienced significantly more throbbing, shooting, stabbing, sharp, burning, and tender pain than the VC group. Regarding, the emotional aspects of pain, they significantly felt the pain tiring- exhausting, sickening, fearful, and punishing-cruel. These results suggest that the SF-MPQ may be a useful questionnaire in the evaluation of CTP.
Systems and methods for communicating a dose history configured for representing an average and a variability of a distribution of injections with a blood glucose regulating medicament applied by a subject with a treatment regimen. Past records are obtained from insulin pens applying the treatment regimen. Each record specifies an amount and type of medicament injected, the type being one of a blood glucose regulating medicament, and a timestamp. Assigning single-shape polygons (231) to each record, wherein single-shape polygons (231) is configured for visualizing a polygon (261) with a two-dimensional shape, in a displayed mode. The single-shape polygons are used to create a set of multi-shape data structures comprising corresponding multi-shape polygons (244), configured for visualizing a polygon (265) with a two-dimensional shape, in the displayed mode (260). The multi-shape polygons are configured to be displayed with an increasing intensity, depending on the number of overlapping single-shape polygons used to define the multi-shape polygon. The method also comprises communicating display data (247), comprising (i) the plurality of sets of medicament records, and (ii) the set of multi-shape data structures (240).
The invention relates to the use of longstamen onion bulb as a medicament for preventing intestinal adhesion. In the invention, longstamen onion bulb decoction is used as a medicament for preventing celiac adhesion and intestinal adhesion, wherein the weight ratio of the longstamen onion bulb and water is 1:2-2.5. In the invention, the functions and actions of activating yang, dissipating stagnation, promoting the circulation of qi and removing food retention of the longstamen onion bulb are used to strengthen enterocinesia, stimulate the rhythmization of the peristalsis of the small intestine and the entire digestive tract and prevent adhesion; therefore, the longstamen onion bulb has a function of preventing intestinal adhesion and can prevent intestinal adhesion and intestinal obstruction due to adhesions. For proving the use of invention, the applicant has conducted animal experiments and clinic applications of the longstamen onion bulb decoction. Clinic applications prove that early use of the longstamen onion bulb has an excellent prevention effect on the post-operation intestinal adhesion of patients receiving abdominal operation and helps the patients to restore quickly and start to eat and leave hospital early. The longstamen onion bulb is edible, so the preparation can be used as both medicine and food. The decoction is cheap and convenient to prepare and take; and after the decoction is taken, adverse effects are avoided, so the decoction is safe and effective. Animal experiments and clinic applications show that the longstamen onion bulb decoction has no adverse effects.
When fluorouracil topical solution USP, 5% is applied to a lesion, a response occurs with the following sequence: erythema, usually followed by vesiculation, desquamation, erosion, and re-epithelialization.  
Fluorouracil topical solution USP, 5% should be applied preferably with a nonmetal applicator or suitable glove. If fluorouracil is applied with the fingers, the hands should be washed immediately afterward.  


Actinic or Solar Keratosis:   
Apply solution twice daily in an amount sufficient to cover the lesions. Medication should be continued until the inflammatory response reaches the erosion stage, at which time use of the drug should be terminated. The usual duration of therapy is from 2 to 4 weeks. Complete healing of the lesions may not be evident for 1 to 2 months following cessation of fluorouracil therapy.

Superficial Basal Cell Carcinomas:   
Only the 5% strength is recommended. Apply solution twice daily in an amount sufficient to cover the lesions. Treatment should be continued for at least 3 to 6 weeks. Therapy may be required for as long as 10 to 12 weeks before the lesions are obliterated. As in any neoplastic condition, the patient should be followed for a reasonable period of time to determine if a cure has been obtained.
A compsn. for colouring skin comprising a vehicle containing an alcohol component and an acid dye component; (a) the alcohol component is selected from the gp. consisting of aromatic alcohols, aliphatic alcohols, and mixtures of these, being capable of penetrating the skin to alter the hydrophobic or hydrophilic structures. (b) The acid dye component comprises an acid dye selected from the gp. consisting of ext. D and C Violet number 2, FD and C Blue number 1, D and C Orange number 4, FD and C Yellow number 6, D and C Yellow number 10, D and C Green number 5, FD and C Red number 4, FD and C Yellow number 5 mixtures of these having a max. pH 4. Process for colouring skin comprising applying to the area of skin to be coloured, a sufficient quantity of the compsn. in which the alcohol component is a combination of benzyl alcohol and ethanol, or the acid dye component is a combination of ext. D and C Violet number 2, D and C Orange number 4 and FD and C Yellow number 6, or the alcohol comprises 1-40 wt.% based on total wt. of compsn. and the dye comprises 0.01-1 wt.%, to colour the skin, allowing the compsn. to remain in contact with the area of skin for enough time to get the degree of skin colouring desired and then removing the excess of compsn. are individually claimed.
A sprayable emulsion is provided. The emulsion can be used in the treatment of various skin conditions. The emulsion includes a hydrofluoro-based propellant, an emulsification system, an oil phase, a water phase, and active agent particles. Further, the emulsification system includes at least one nonionic emulsifier. The emulsion has a viscosity ranging from about 500 centipoise to about 10,000 centipoise and a hydrophilic to lipophilic balance (HLB) value of from about 2 to about 12. The present inventors have found that by selectively controlling the nature of the emulsification system and the viscosity of the emulsion, the active agent particles resist settling such that a substantially homogeneous distribution of the active agent particles is maintained and can be evenly sprayed onto a surface without running once applied.
<P>PROBLEM TO BE SOLVED: To provide a container for a foaming agent that can easily produce foam on hot water surface by soap component or the like and to supply a foaming agent to contain the agent.  <P>SOLUTION: The container includes floating parts 22 and 34 that float on the water surface and discharge outlets 33 that are provided above the waterline of the floating part 34 to discharge foam produced by a surfactant component from the inside to the outside. An almost inverse conical bag member 12 is provided on the lower side of the floating part 22 and an inlet 14 is provided near the top 12a of the bag member 12 to take water from the outside into the inside. Multiple discharge outlets 33 are provided almost at regular intervals along the circumferences of the floating parts 22 and 34. The foaming agent 42 contains a bubble generation agent 44 that generates CO<SB>2</SB>and a soap component that is a surfactant component.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Participants will receive pembrolizumab and vibostolimab via an IV infusion Q3W for up to 35 cycles. Each cycle is 21 days.
The patient underwent postoperative adjuvant radiotherapy. CTV : 40Gy/15fx/3w, sequential GTV： 8.7-10Gy/3-4 Fx.
This is a multicenter randomized open-label clinical study in patients with Wagner grade 1 and 2 DFUs. Diabetic patients presenting with chronic nonhealing ulcers will be screened for eligibility. At least 50% of the eligible population will be drawn from patients ≥ 65 years of age. All patients will complete a 2-week run-in period prior to treatment allocation to Amnio-Maxx and standard of care (SOC) or SOC alone. Patients will be seen at weekly intervals (± 3 days) for the 12 weeks treatment period. If additional dressing changes are required between the scheduled visits, the occurrence of these visits will be recorded. Primary efficacy endpoints include percentage change in ulcer size at 12 weeks along with the proportion of participants achieving complete wound closure. Additionally, pain and safety will be assessed as secondary endpoints.
Procedure for the obtaining of phenylquinolicidins, formula (I), in which x, y, r, r and r can be several types of radicals. It consists of the reaction of a formula (II) phenylendiamine, in which all symbols have the same meaning as in formula (I), thiophosene, tiocarbonildiimidazole or carbon disulfide. The reaction is carried out following conventional methods. The racematos obtained can be resolved in the optical antipodas. These compounds have pharmacological applications for their neuroletic, antimimetic and/or analgesic activities. (Machine-translation by Google Translate, not legally binding)
This study aimed to compare the structural features and functional properties of polysaccharides from single-clove garlic (SGPs) and multiclove garlic (MGPs) and to establish their structure-function relationships. Both SGPs and MGPs were identified as fructans consisting mainly of →1)-β-d-Fruf (2→ and →6)-β-d-Fruf (2→ residues but differed in average molecular weights (6.76 and 5.40 kDa, respectively). They shared similar thermodynamic properties, X-ray diffraction patterns, and high gastrointestinal digestive stability. These two purified fructans could dose-dependently scavenge free radicals, reduce oxidized metals, and effectively alleviate metronidazole-induced oxidative stress and CuSO4-induced inflammation in zebrafish via inhibiting the overexpression of inflammation-related proteins and cytokines. SGPs showed lower free radical scavenging activity in vitro than MGPs but higher antioxidant and anti-inflammatory activities in vivo. Taken together, the molecular weight was the main structural difference between the two garlic fructans of different varieties, which is a potential reason for their differences in biological activities.