anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Interpersonal bias based on weight and race is widespread in the clinical setting; it is crucial to investigate how emerging genomics technologies will interact with and influence such biases in the future. The current study uses a virtual reality (VR) simulation to investigate the influence of apparent patient race and provision of genomic information on medical students' implicit and explicit bias toward a virtual patient with obesity. Eighty-four third- and fourth-year medical students (64% female, 42% White) were randomized to interact with a simulated virtual patient who appeared as Black versus White, and to receive genomic risk information for the patient versus a control report. We assessed biased behavior during the simulated encounter and self-reported attitudes toward the virtual patient. Medical student participants tended to express more negative attitudes toward the White virtual patient than the Black virtual patient (both of whom had obesity) when genomic information was absent from the encounter. When genomic risk information was provided, this more often mitigated bias for the White virtual patient, whereas negative attitudes and bias against the Black virtual patient either remained consistent or increased. These patterns underscore the complexity of intersectional identities in clinical settings. Provision of genomic risk information was enough of a contextual shift to alter attitudes and behavior. This research leverages VR simulation to provide an early look at how emerging genomic technologies may differentially influence bias and stereotyping in clinical encounters.
Adverse reactions to succinylcholine consist primarily of an extension of its pharmacological actions. Succinylcholine causes profound muscle relaxation resulting in respiratory depression to the point of apnea; this effect may be prolonged. Hypersensitivity reactions, including anaphylaxis, may occur in rare instances. The following additional adverse reactions have been reported: cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia, tachycardia, hypertension, hypotension, hyperkalemia, prolonged respiratory depression or apnea, increased intraocular pressure, muscle fasciculation, jaw rigidity, postoperative muscle pain, and rhabdomyolysis with possible myoglobinuric acute renal failure, excessive salivation, and rash.  
  
There have been post-marketing reports of severe allergic reactions (anaphylactic and anaphylactoid reactions) associated with use of neuromuscular blocking agents, including succinylcholine. These reactions, in some cases, have been life threatening and fatal. Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency (see WARNINGS and PRECAUTIONS).

To report SUSPECTED ADVERSE REACTIONS, contact Indoco Remedies Limited at +1-855-642-2594 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Despite increasing recognition of the significance of mild traumatic brain injury (mTBI), the long-term cognitive consequences of the injury remain unclear. More sensitive measures that can detect subtle cognitive changes and consideration of individual variability are needed to properly characterise cognitive outcomes following mTBI. Here, we used complex behavioural tasks, individual differences approaches, and electrophysiology to investigate the long-term cognitive effects of a history of mTBI. In Experiment 1, participants with self-reported mTBI history (n=82) showed poorer verbal working memory performance on the operation span task compared to control participants (n=88), but there were no group differences in visual working memory, multitasking, cognitive flexibility, attentional control, visuospatial ability, or information processing speed. Individual differences analyses revealed that time since injury and presence of memory loss predicted visual working memory capacity and visuospatial ability, respectively, in those with mTBI history. In Experiment 2, participants with mTBI history (n=20) again demonstrated poorer verbal working memory on the operation span task compared to control participants (n=38), but no group differences were revealed on a visuospatial complex span task or simpler visual working memory measures. We also explored the electrophysiological indices of visual working memory using EEG during a change detection task. No differences were observed in early sensory event-related potentials (P1, N1) or the later negative slow wave associated with visual working memory capacity. Together, these findings suggest that mTBI history may be associated with a lasting, isolated disruption in the subsystem underlying verbal working memory storage. The results emphasise the importance of sensitive cognitive measures and accounting for individual variability in injury characteristics when assessing mTBI outcomes.
Vitamins are extracted from natural materials such as fats and oils by acting directly on the raw material with a solution of acetone and hydrocarbons either simultaneously with, or subsequent to, the addition of a saponifying agent, and without the previous separation of the saponifiable and unsaponifiable matter. Modifications of the above process which are described comprise: (1) the saponification of the raw materials in the presence of acetone, followed by extraction with a hydrocarbon solvent after saponification is completed; (2) the saponification of the raw materials in the presence of a hydrocarbon solvent, followed by addition of acetone after the saponification is completed, and the removal of the hydrocarbon layer containing the vitamins; (3) the saponification of the raw materials in the presence of both acetone and a hydrocarbon solvent, followed by the removal of the hydrocarbon layer containing the vitamins when the saponification has been completed.  The term " hydrocarbons" includes any hydrocarbon spirit liquid at ordinary temperatures and having a boiling point not exceeding 175 DEG  C.  Examples are benzene, benzine, and petroleum ether.  It is preferred that the hydrocarbon oils used for extraction purposes in the present invention should be first subjected to a purification treatment comprising mixing the hydrocarbon with heavy oils and then distilling off the hydrocarbons ready for use.  It is stated that noxious impurities may be removed in this way.  A preferred purification comprises the addition of 20 kilos. of a vegetable or animal oil, or a pure heavy mineral oil to 80 kilos. of hydrocarbon, followed by the distillation of 70--75 kilos. of the hydrocarbon.  The residue is rejected.  In examples: (1) liver oil is saponified with aqueous potassium hydroxide in the presence of acetone either under pressure or under reflux.  After saponification, the vitamins are extracted by a hydrocarbon solvent such as benzine, preferably added in the proportion of one volume of benzine to one volume of solution.  On the second and subsequent extractions it is usually necessary to add more acetone to avoid the formation of emulsions; (2) the saponification is performed in the absence of acetone, which is then added in an amount sufficient to dissolve all the soap.  The solution is then treated as in example (1); (3) the raw material is dissolved in benzine, saponified, acetone added and then the extraction performed as in example (1); (4) the oil is saponified in the presence of acetone and petroleum ether.  After saponification, the extraction is carried out as in example (1).  Specifications 362,023 and 393,883 are referred to.
The present invention belongs to a ruminant trace element supplementary feeding technology and the field of a rumen slow release technology, which relates to a heat treatment method for a slow release material and a bullet molding technology. The formula components of the nutrient slow release bullet has the weight percentages that 0.02 to 0.06% of cobalt, 1.9 to 6.0% of copper, 0.02 to 0.3% of iodine, 8.25 to 30% of iron, 5 to 13% of manganese, 0.02 to 0.06% of selenium, 5 to 18% of zinc, and excipient which is used as the rest amount. 20 to 30% of the mixture of trace elements with the compounding ratios is taken, and 20 to 30% of excipient beewax, 20 to 30% of sodium stearate and 30 to 40% of red clay are added into the mixture. Reasonable formula is realized according to prescriptions of different livestock kinds. A livestock slow release bullet for ruminant is formed by grinding, mixing, heating, melting, casting and shaping in a bullet die. The present invention has the purposes of reducing the generation of livestock nutrient metabolic diseases by feeding nutrient slow release bullets to pasture livestock, and improving the yield efficiency of pasture animal husbandry. The present invention is a high efficient and low-priced supplementary feeding product which is invented by aiming at serious contradiction of livestock in pastoral areas. The present invention has good economic and social benefit.
The invention belongs to the technical field of processing of Chinese herbal medicines and discloses a stasis eliminating and swelling relieving medicine. The medicine is prepared from herba linderniae antipodae, radix paeoniae alba, herba clinacanthi nutantis, herba peristrophi, radix stellariae yunnanensis, radix perillea acutae, semen artemisiae ordosicae, rice wine and the like. Herba linderniae antipodae has efficacies of heat clearing, detoxifying, diuresis promoting, stranguria treating, blood circulation promoting and swelling relieving; herba clinacanthi nutantis has efficacies of heat clearing, damp eliminating, blood circulation promoting, muscle and tendon relaxing and stasis removing, and contained lupeol, betulin and sitosterol have a cancer growth inhibition function and have prevention and treatment effect on various carbuncles and tumors. Radix paeoniae alba has efficacies of blood nourishing, harmonizing, pain relieving, Yin restraining, liver calming, and herba clinacanthi nutantis, herba linderniae antipodae, herba peristrophi, radix stellariae yunnanensis, radix perillea acutae and the like have efficacies of heat clearing, diuresis promoting, detoxifying, pain relieving, Qi circulation promoting, blood activating, stasis eliminating and swelling relieving, so that optimal efficacies are achieved by compatibility. Radix paeoniae alba with unique functions of Yin-Yang balancing, Yang inhibiting, liver calming, heat toxin and pathogenic factor eliminating and blood circulation promoting improves medicinal healing effects in compatibility. By oral administration and external application, symptoms of blood stasis, swelling, ulcerative carbuncles, pyogenic infections, tumors and the like can be treated, and remarkable curative effects and convenience, simplicity and feasibility in use are realized.
The invention provides a drug sustained-release preparation, which has good patient compliance, small side effect, durable and stable efficacy, and can further be produced into tablets. The drug sustained-release preparation comprises a main drug and macromolecular polymer which is sensitive to pH. The macromolecular polymer is used as a framework material, and has different physical properties in the gastrointestinal tract under different pH values, and the drug release is benefited when the molecular weight of the macromolecular polymer is larger than 5000. Moreover, the macromolecular polymer contains anion or cation, and comprises but is not limited to alginic acid and salt thereof or chitosan or carbomer or poloxamer. The drug sustained-release preparation further comprises hydrophobic matrix. The hydrophobic matrix can be selected according to the preparation requirement, i.e. the hydrophobic matrix can be not only a filling agent, a lubricating agent and the like but also a sustained-release framework material; and moreover, the hydrophobic matrix can be further used with the macromolecular polymer to control the drug release together.
The invention relates to a skin care product, in particular to an A-Fib aloe extract composition, which belongs to the field of cosmetics. The aloe extract comprises aloe ferox miller extract, paeoniflorin, fresh water pearl solution, grape seed oil, beta-glucosan, pollen, leucine and lysine. The skin care product can be used every day as a cream, facial cleaner, facial essence or lotion. The skin care product has the double functions of surface layer moistening and dermis water replenishing, and can replenish the skin deep layer with water, promote skin water metabolism, effectively prevent the electromagnetic radiation of a computer and the like from damaging the skin, effectively improve skin elasticity while moistening the skin, and avoid skid premature aging. The skin care product is particularly suitable for the daily use of people living in the environments of computer radiation and air conditioning. The aloe extract composition can prevent skin dryness and winkles, and the long-term use of the aloe extract composition can achieve whitening effect.
Patients undergo apheresis to obtain T cells for product manufacturing. Patients receive lymphodepleting chemotherapy with fludarabine IV on days -4 to -1 and cyclophosphamide IV on days -4 and -3. Patients receive FH-FOLR1 CAR T IV on day 0. Patients undergo ECHO at screening, undergo collection of CSF and blood samples and bone marrow aspiration/biopsy throughout the study, and may undergo PET scan on study and during follow up.
The RAB interacting factor (RABIF) is a putative guanine nucleotide exchange factor that also functions as a RAB-stabilizing holdase chaperone. It has been implicated in pathogenesis of several cancers. However, the functional role and molecular mechanism of RABIF in hepatocellular carcinoma (HCC) are not entirely known. Here, we demonstrate an upregulation of RABIF in patients with HCC, correlating with a poor prognosis. RABIF inhibition results in decreased HCC cell growth both in vitro and in vivo. Our study reveals that depleting RABIF attenuates the STOML2-PARL-PGAM5 axis-mediated mitophagy. Consequently, this reduction in mitophagy results in diminished mitochondrial reactive oxygen species (mitoROS) production, thereby alleviating the HIF1α-mediated downregulation of glycolytic genes HK1, HKDC1, and LDHB. Additionally, we illustrate that RABIF regulates glucose uptake by controlling RAB10 expression. Importantly, the knockout of RABIF or blockade of mitophagy sensitizes HCC cells to sorafenib. This study uncovers a previously unrecognized role of RABIF crucial for HCC growth and identifies it as a potential therapeutic target.
ISSUE ADDRESSED: Obesity in children is one of the most significant public health issues globally. Given the high prevalence of overweight and obesity in children, there is a need to identify effective obesity prevention efforts that can be delivered at scale to improve child health. We aimed to (i) identify obesity prevention interventions targeted at children aged 0-2 that have been scaled-up, and their relative efficacy compared to their pre-scale trial, (ii) describe adaptations made, and the extent to which factors related to scalability have been reported.
METHODS: We conducted a rapid review of pre-scale randomised controlled trials targeting nutrition, physical activity and obesity prevention in infants, and calculated the relative effect size for relevant outcomes in the corresponding scaled up trial. We documented adaptations made to the pre-scale trial for scale up, and explored how different components of scalability had been reported according to the Intervention Scalability Assessment Tool.
RESULTS: Of the 14 identified pre-scale trials, only one formal evaluation of the scale-up trial was identified. For body mass index, <10% of the effect was retained, however for nutrition and behavioural outcomes, the proportion of effect retained varied from -11.1% to 144%. Significant adaptations to modality were made in the scaled up trial primarily to reduce cost and increase reach of the intervention. Reporting of scalability components varied across the 14 trials, with only one trial reporting information for all assessed components.
CONCLUSIONS: The majority of effective interventions targeting obesity prevention in infants have not been evaluated in a scaled up form. The magnitude of effect retained for the single trial that was scaled up was variable. In general, reporting of components of scalability was sub-optimal. SO WHAT?: The findings suggest that there is substantial need for the development and rigorous evaluation of obesity prevention interventions in children aged 0-2 which are amenable for scale.
Acupuncture will be provided up to once daily for one or more days till the day of discharge or 5 days, whichever occurs first. Patients will continue to receive their standard pain management regime including IV opioids, ketorolac and fluids. Minimum number of sessions received by the acupuncture group will be one.
BACKGROUND AND OBJECTIVE: Acute Kidney Injury (AKI) is a common and severe complication in patients diagnosed with sepsis. It is associated with higher mortality rates, prolonged hospital stays, increased utilization of medical resources, and financial burden on patients' families. This study aimed to establish and validate predictive models using machine learning algorithms to accurately predict the occurrence of AKI in patients diagnosed with sepsis.
METHODS: This retrospective study utilized real observational data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. It included patients aged 18 to 90 years diagnosed with sepsis who were admitted to the ICU for the first time and had hospital stays exceeding 48 hours. Predictive models, employing various machine learning algorithms including Light Gradient Boosting Machine (LightGBM), EXtreme Gradient Boosting (XGBoost), Random Forest (RF), Decision Tree (DT), Artificial Neural Network (ANN), Support Vector Machine (SVM), and Logistic Regression (LR), were developed. The dataset was randomly divided into training and test sets at a ratio of 4:1.
RESULTS: A total of 10,575 sepsis patients were included in the analysis, of whom 8,575 (81.1%) developed AKI during hospitalization. A selection of 47 variables was utilized for model construction. The models derived from LightGBM, XGBoost, RF, DT, ANN, SVM, and LR achieved AUCs of 0.801, 0.773, 0.772, 0.737, 0.720, 0.765, and 0.776, respectively. Among these models, LightGBM demonstrated the most superior predictive performance.
CONCLUSIONS: These machine learning models offer valuable predictive capabilities for identifying AKI in patients diagnosed with sepsis. The LightGBM model, with its superior predictive capability, could aid clinicians in early identification of high-risk patients.
OBJECTIVE: The goal of this study was to analyze trends in treatment access for chronic superficial venous disease and to identify disparities in care.
METHODS: This retrospective study was exempt from institutional review board approval. The American College of Surgeon National Surgical Quality Improvement Program database was used to identify patients who underwent vein stripping (VS) and endovenous procedures for treatment of chronic superficial venous disease. Endovenous options included radiofrequency ablation (RFA) and laser ablation. Data was available from 2011 to 2018 and demographic information was extracted for each patient identified by Current Procedural Terminology codes. For all racial and ethnic groups, trend lines were plotted, and the relative rate of change was determined within each specified demographic.
RESULTS: There were 21,025 patients included in the analysis. The overall mean age was 54.2 years, and the majority of patients were female (64.8%). In total, 27.9%, 55.2%, and 16.9% patients underwent VS, RFA, and laser ablation, respectively. Patients who received laser ablation were older (P < .001). Hispanic ethnicity was associated with significantly lower odds of receiving endovascular thermal ablation (EVTA) over VS (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.64-0.78; P < .001). American Indian/Alaska Native patients were more likely to receive EVTA over VS (OR, 4.02; 95% CI, 2.48-6.86); similarly, Native Hawaiian/Pacific Islander patients were more likely to receive EVTA over VS, although this difference was not statistically significant (OR, 1.44; 95% CI, 0.93-2.27). On multinomial regression, Hispanic patients were less likely to receive RFA over VS, whereas American Indian/Alaskan Native patients were more likely to receive RFA over VS. In all racial and ethnic groups, the percentage of endovenous procedures increased, whereas vein stripping decreased.
CONCLUSIONS: Based on a hospital-based dataset, demographic indicators, including age, sex, race, and ethnicity, are associated with differences in endovenous treatments for chronic superficial venous insufficiency suggesting disparities in obtaining minimally invasive treatment options among certain patient groups.
Non-synthetic hair lotion for treatment of dandruff contains 81% cider vinegar, 9% orange flower extract, 5% rose extract and 5% of lavender extract. Other plant and fruit extracts obtained by cold pressing in a cold chamber and seiving, may be added. Pref. extracts are: bittersweet and rosemary; clematis; garlic and onion juices; olive oil, lemon juice and nettle extract. Amounts of these additives are e.g. 1-2%, based on cider vinegar. The first three compositions are esp. useful for brunette, blonde and bald people respectively.
The invention relates to an application of a natural compound, and relates to a new application of Shikonin, and an application of Shikonin in preparation of medicines for treating acute leukemia. The English name of the Shikonin is Shikonin, the CAS No. is 517-89-5, a molecular formula is C16H16O5, the molecular weight is 288.3, and a chemical name of the Shikonin is 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)naphthalene-1,4-dione. The employed Shikonin is extracted from plants or chemically synthesized according to the prior art, the prepared medicines are individual Shikonin or contain other antitumor drug, and an excipient or a carrier of the medicinal preparation. According to the invention, the effectively increased cell active oxygen and an appropriately activated Nrf2 approach to cause the differentiation of acute leukemia cells, so that the form and function of normal cells can be approached or completely possessed. In the provided concentration range, the Shikonin induces the abnormal leukemia cells to be obviously differentiated, and simultaneously appears nonlethal low toxicity effect, so that the Shikonin has good application prospect for preparing the medicines for anti-acute leukemia.