anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients weighing 10 to \<15 kg received ATV powder, 200 mg, dosed in 50-mg sachet packets and RTV oral solution, 80 mg. Stage 1: Initial dose was determined by the patient's weight on the day of the first on-treatment study visit (Day 1). ATV dispersible powder was mixed with a small amount of food or beverage (water, milk, chocolate milk, liquid infant formula, applesauce, or yogurt). All of the mixture must have been consumed to obtain the full dose. The RTV oral solution was taken immediately before or after the ATV powder preparation. Stage 2: Patients who reached the age of 6 years or a weight of ≥25kg transitioned from the powder to the capsule formulation of ATV. Patients who weighed 15 to \<20 kg received ATV, 150 mg with RTV, 100 mg; those who weighed 20 to \<40 kg received ATV, 200 mg, and RTV, 100 mg; and those who weighed at least 40 kg received ATV, 300 mg with RTV, 100 mg. RTV capsules or tablets were ingested with food immediately before or after ATV intake.
PURPOSE OF REVIEW: The traditionally understated role of neural regulation in fracture healing is gaining prominence, as recent findings underscore the peripheral nervous system's critical contribution to bone repair. Indeed, it is becoming more evident that the nervous system modulates every stage of fracture healing, from the onset of inflammation to repair and eventual remodeling.
RECENT FINDINGS: Essential to this process are neurotrophins and neuropeptides, such as substance P, calcitonin gene-related peptide, and neuropeptide Y. These molecules fulfill key roles in promoting osteogenesis, influencing inflammation, and mediating pain. The sympathetic nervous system also plays an important role in the healing process: while local sympathectomies may improve fracture healing, systemic sympathetic denervation impairs fracture healing. Furthermore, chronic activation of the sympathetic nervous system, often triggered by stress, is a potential impediment to effective fracture healing, marking an important area for further investigation. The potential to manipulate aspects of the nervous system offers promising therapeutic possibilities for improving outcomes in fracture healing. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.
<P>PROBLEM TO BE SOLVED: To provide a hollow nanoparticle for specifically introducing a substance into a target cell or tissue and providing a stable amount of its production, and to provide a drug using the nanoparticle.  <P>SOLUTION: The hollow nanoparticle has a recognition ability for a specific cell such as hepatic cell and is composed of a first protein having a particle-forming ability (e.g. a hepatitis B virus surface antigenic protein). In the hollow nanoparticle, the first protein comprises a protein having an interaction with a second protein forming a capsid structure (e.g. a hepatitis B virus core antigenic protein).  <P>COPYRIGHT: (C)2004,JPO
The primary focus of the study is to understand the mechanisms of adopting safer sex practices among Haitian American (H-A) adolescents. We replicated a Cognitive-Behavioral HIV transmission risk reduction (CB-HIV-TRR) intervention entitled "Becoming A Responsible Teen" (BART, St. Lawrence, et al, 1995; St. Lawrence, 1998). This approach, which emphasizes building skills and self-efficacy in the process of risk reduction, was demonstrated to be highly effective with African American male and female adolescents in Mississippi. In a meta-analysis of published CB-HIV-RR intervention outcome studies (Kalichman, et al., 1996), the BART intervention was shown to have produced the highest effect not only for the published studies with adolescents, but also for HIV prevention interventions of all other populations studied. Based on its promising effects, the BART intervention has been officially designed as one of only four HIV risk "Programs that Work" by CDC Division of Adolescent and School Health (DASH). CDC designates programs as such based on reviewing programs in the literature using rigorous criteria. The proposed work focused on delineating theoretically important conditions associated with HIV transmission risk reduction (HIV-TRR) to address issues of mechanism of action and generalizability, respectively. Specifically, this 5 year study evaluates the effects of a version of the BART intervention that has been adapted to be appropriate to Haitian adolescents in Miami) as compared to a standard care (SC) condition among 160 male and 160 female high risk Haitian adolescents.
Current evidence demonstrates that women with hypertensive disorders of pregnancy have 2-fold higher risk for the later development of cardiovascular disease (CVD) compared to women with healthy pregnancies. CVD prevention is a high priority for women's health, as it is the leading cause of death among women in the United States. In order to improve women's cardiovascular health, interventions for cardiovascular prevention could be initiated shortly after a pregnancy complicated by a hypertensive disorder. However, patient-centered interventions to promote preventive care engagement among postpartum women are lacking. Our objective is to address current gaps in knowledge regarding needs, values, and barriers regarding cardiovascular prevention among postpartum women with hypertensive disorders of pregnancy, and to remedy the lack of available evidence-based interventions for this at-risk population. To this end, we will conduct a pilot study to demonstrate feasibility and preliminary efficacy of a patient decision aid to improve patient knowledge and self-efficacy regarding CVD prevention during the postpartum period
PURPOSE:To obtain a detergent composition, having foaming functions in addition to makeup removing functions and capable of providing a refreshing feeling of washing the bare skin by combining a polyoxtethylene hardened caster oil ester of a fatty acid with an amphoteric surfactant and/or a semipolar surfactant. CONSTITUTION:This skin detergent is obtained by blending a polyoxyethylene hardened castor oil ester of a fatty acid having a fundamental structure expressed by the formula (at least one of R1 to R3 is a saturated or an unsaturated aliphatic hydrocarbon and the rest are H; l, m and n each higher is an integer) with an amphoteric surfactant and/or a semipolar surfactant at a weight ratio of preferably within the range of (1:1) to (1:8). Isostearic acid and oleic acid are preferred as the fatty acid species of the ester expressed by the formula. The average degree of polymerization of ethylene oxide in one molecule of the polyoxyethylene hardened castor oil ester of the fatty acid is preferably within the range of 20 to 50. The surfactant is a betaine type (a carboxybetaine or a sulfobetaine), an amidobetaine type amphoteric surfactants, etc. This detergent is foamed by addition thereof to water.
PROBLEM TO BE SOLVED: To produce a uricosuric agent useful for the treatment of gout and other hyperuricacidemia by including a specific compound having uricosuric action as an active component. SOLUTION: The objective agent contains a compound having uricosuric action and expressed by formula I (A is O or the like; B is O or the like; R1 is H or the like; R2 is a lower alkyl or the like; R3 is H or the like; R4 is nitro or the like) or its pharmacologically permissible salt (e.g. 4'-methyl-1,1'- biphenyl-2-carbonitrile) as an active component. The compound of formula I can be produced e.g. by reacting a compound of formula II (e.g. 2- bromobenzonitrile) with a compound of formula III (B is baron) (e.g. 4- methylbenzeneboronic acid) in the presence of a catalyst such as tetrakistriphenylphosphinepalladium chloride and a base such as potassium carbonate in a solvent such as toluene at room temperature or under heating. The daily administration rate of the compound of formula I for adult is preferably 5-200 mg.
The invention relates to a targeting hepatoma cell preparation and a preparation method thereof. Particularly, the invention provides an isolated polynucleotide which comprises a nucleotide sequence encoding a polypeptide, and the polypeptide comprises a structural domain, a spacer domain, a transmembrane domain and a T cell activation structural domain which are used for identifying antigens on the surfaces of hepatitis B viruses. The invention also provides a eukaryotic expression vector which comprises the polynucleotide. The invention further comprises a method for preparing a cell preparation of a T cell including a targeting hepatoma cell. The method comprises the step of utilizing the eukaryotic expression vector to convert and isolate a peripheral blood mononuclear cell. The invention also relates to application of the cell preparation to preparation of a medicine composition used for treating liver cancer.
Subjects received placebo tablets, administered orally once daily for 12 weeks. Subjects continued taking stable anti-hypertensive regimen throughout the study.
Takotsubo syndrome (TTS) is a particular form of acute heart failure that can be challenging to distinguish from acute coronary syndrome at presentation. TTS was previously considered a benign self-limiting condition, but it is now known to be associated with substantial short- and long-term morbidity and mortality. Because of the poor understanding of its underlying pathophysiology, there are few evidence-based interventions to treat TTS. The hypotheses formulated so far can be grouped into endogenous adrenergic surge, psychological stress or preexisting psychiatric illness, coronary vasospasm with microvascular dysfunction, metabolic and energetic alterations, and inflammatory mechanisms. Current evidence demonstrates that the infiltration of immune cells such as macrophages and neutrophils play a pivotal role in TTS. At baseline, resident macrophages were the dominant subset in cardiac macrophages, however, it underwent a shift from resident macrophages to monocyte-derived infiltrating macrophages in TTS. Depletion of macrophages and monocytes in mice strongly protected them from isoprenaline-induced cardiac dysfunction. It is probable that immune cells, especially macrophages, may be new targets for the treatment of TTS.
Solubilizing, or improving solubility of, a peptide (I) in aqueous medium comprising covalent attachment of at least 3 residues of Lys, in L or D form, distributed over the N and/or C termini in the form of a linear or branched chain, is new. Independent claims are also included for: (1) peptide ligand (Ia) of MHC (major histocompatibility complex) modified by attachment of at least 3 residues of Lys, in L or D form, distributed over the N and/or C termini in the form of a linear or branched chain; and (2) vaccine containing at least one peptide that contains at least one hydrophobic epitope derived from an antigenic protein of a microbial pathogen or tumor and modified by the new method or is (Ia). ACTIVITY : Virucide; Antibacterial; Parasiticide; Fungicide; Cytostatic. The modified influenza matrix M1 peptide (4K-FluM1) of sequence (Arg) 4-Glu-Ile-Leu-Gly-Phe-Val-Phe-Thr-Leu was administered (twice, 100 Microg plus 300 Microg of the P40 adjuvant) subcutaneously to mice. Ten days later, spleen cells were recovered and cultured in presence of interleukin-2 and of fixed antigen-presenting cells loaded with FluM1. The effector cells were restimulated after 7 days, then after a further 5 days they were tested in a chromium release assay against EL4 A2/kb cells loaded with peptide. At an effector:target ratio 100, the specific lysis was about 75%. MECHANISM OF ACTION : Vaccine; Gene Therapy.
We aimed to analyze the association between the average lumbar subcutaneous fat tissue thickness (LSFTT) at each intervertebral level and the presence of hernias in patients with low back pain from an insurance network hospital in Mexico. This observational prospective study included 174 patients with non-traumatic lumbago who underwent magnetic resonance imaging with a 1.5T resonator. Two independent radiologists made the diagnosis, and a third specialist provided a quality vote when needed. The sample size was calculated with a 95% confidence interval using random order selection. Anonymized secondary information was used. Percentages and means with confidence intervals were tabulated. The area under the curve, specificity, and sensitivity of LSFTT were calculated. A regression analysis was performed to analyze the presence of hernias with LSFTT using each intervertebral level as a predictor. The odds of herniation at any intervertebral level increased directly with LSFTT. The average LSFTT predicted the overall presence of hernias; however, the LSFTT at each intervertebral level better predicted hernias for each intervertebral space. The area under the curve for LSFTT in predicting hernias was 68%. In conclusion, the average LSFTT was associated with the overall presence of hernias; patients with more hernias had higher LSFTT values.
Earlier research at the Faculty of Economics and Business (FEB) has demonstrated generalization of reward sensitivity after sensory stimulation in a different domain. As increased sensory stimulation in the sexual domain (Van den Bergh et al. 2008) or the power domain (Briers et al. 2007), the preference for immediate small financial reward increased deferred pay. Hongda, DeWitte \& Warlop (2008) were able to neutralize this effect by domain-specific financial satiation. In this research, The investigators investigate the possible influence of (subliminal) intragastric administration of fatty acids in reward sensitivity in the power domain, and whether this effect generalizes to financial and sexual domain. Previous research at the Translational Research Center for Gastrointestinal Disorders (TARGID) showed that such administration can neutralize the effects of mood-priming (Van Oudenhove et al., 2011). This study aims to examine the implications of those findings in the motivational domain.

60 healthy heterosexual men come to the lab twice, once for the fatty acid condition, once for the control condition (counterbalanced, and randomly assigned to sequence condition). In each session the same dv's are measured (first three tasks counterbalanced, progressive ratio task always at the end). At the end of the second session, participants also compete a series of interindividual difference measures (scales).

This research forms the start of a collaboration between TARGID and the Center for Research in Marketing and Consumer Science at KU Leuven Faculty of Business and Economics. The current paradigm is largely based on an earlier study by Prof. Dr. Lukas Van Oudenhove showing the effect of intragastric administration of an identical fatty acid solution tested for mood regulation (Van Oudenhove et al., 2011). The procedure performed in this study, which is placing a thin nasogastric tube is frequently used in the TARGID research and other research and is absolutely proven to be safe, with no mention of any adverse reactions during numerous previous studies. Similar studies by our research group had already been approved by the Medical Ethics Committee, and as always sees Prof. Tack ensure that the study conducted by researchers who have received adequate training and have acquired sufficient experience in this specific procedure before the start of the study. The procedure can be carried out in healthy volunteers in a perfectly safe manner.
Psoriasis is a common autoimmune disease. It affects women of all ages including reproductive years. Almost 75% of patients are diagnosed before the age of 40. There is also increased evidence on autoimmune disease and their link to premature ovarian failure.Ovarian reserve is important for the reproductive period. The measurements of serum hormones including follicle stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL), estradiol (E2) and anti-mullerian hormone (AMH) will give us an idea about the ovarian reserve. The investigators aim is to measure ovarian reserve parameters in patients newly diagnosed with psoriasis and to compare them to healthy controls. Serum FSH,LH,E2,PRL and AMH will be measured on the 3rd day of the cycle.The serum hormone levels will be compared between women with psoriasis and women without psoriasis
The goal of the main study is to test the hypothesis that messages promoting promising smoking-related belief themes identified by the Hornik and Woolf (1999) method will increase anti-smoking intentions to a greater extent than less-promising belief themes. This hypothesis will be tested by exposing research participants to messages based on a range of belief themes and comparing their anti-smoking intentions across conditions. Using the method described by Hornik and Woolf (1999), promising and less-promising smoking-related beliefs are identified using cross-sectional survey data that examines the association between smoking-related beliefs and intentions. The research team has previously used this method to advise campaign developers as to which smoking-related beliefs they should target in anti-smoking campaigns, although our cross-sectional evidence was only suggestive because it could not tease apart the causal order of beliefs and intentions (i.e., do people with anti-smoking beliefs have intentions not to smoke, or do people who don't intend to smoke develop more anti-smoking beliefs). Because our evidence has been cross-sectional, it is currently unknown whether anti-smoking messages based on promising smoking-related beliefs are indeed more likely to increase intentions not to smoke. Therefore, there are two parts to the study that we will conduct experimentally. First, in the pilot study, we will pretest a larger set of themes than will be used in the main study to ensure that the themes we do use (whether promising or unpromising) are equally convincing. Otherwise, there may be a difference in intentions based on treatment group simply because the manipulation did not work in one group and did in another, not because holding promising beliefs is actually more effective at increasing intentions. Our claim is that if it were possible to convince people of both types of beliefs (promising and less-promising), they would be less likely to smoke in the promising case than in the less-promising case because those beliefs are more powerful at changing intentions. For the main study, we will therefore use a smaller set of themes and experimentally manipulate which respondents are exposed to promising smoking-related messages and which are exposed to less-promising smoking-related messages. We expect that the randomly assigned groups will endorse promising and less-promising smoking-related beliefs to different extents. This will allow us to test our hypothesis that promising beliefs are more effective at increasing anti-smoking intentions by examining differences in smoking-related intentions based on treatment group (exposure to either promising or less-promising messages).
Because the study investigates a potentially beneficial effect of including the client directly in treatment decisions (by having the client determine the order of treatment modules together with the therapist), the patient-centred version of the treatment is compared with a control treatment, where the five treatment modules are delivered in a predefined order. The control treatment thus consists of the same treatment components as described above. It is only the aspect of co-decision that has been taken out. Instead, the therapist will just inform the client about the order of treatment modules in the programme. The order of treatment modules in the control treatment will be: 1) Affect dysregulation (6 sessions), 2) Disturbed relationships (6 sessions), 3) Negative self-concept (6 sessions), 4) PTSD symptoms (6 sessions) and 5) Insomnia and trauma-related nightmares (6 sessions).
Disclosed are sustained release oral pharmaceutical compositions which comprise dicycloverine hydrochloride (dicyclomine, [bicyclohexyl]-1-carboxylic acid 2-(diethylamine)ethyl ester), an anti-spasmodic, in both a core and a film coating of the composition. The core further comprises; one or more binders (e.g. celluloses, starches), one polymer present intragranular, one polymer present extragranular and one of more inactive excipients. The film coating comprises: dicycloverine or a salt thereof, a water soluble film forming polymer and one or more inactive excipients (e.g. plasticiser, opacifier, colouring agent). Both the intragranular polymer and the extragranular polymer may be either hydrophobic or hydrophilic. Preferably, the composition is in the form of a tablet. Also claimed is a method for preparing a sustained release oral pharmaceutical composition.
A monomolecular layer of first biological particles is absorbed on the surface of a non-reactive substrate. The coated substrate is exposed to a solution suspected of containing second biological particles specific to the first biological particles. Next, the coated substrate is subjected to a tagging step, following which it is exposed to a cleaving agent solution which cleaves the bond between the first and second biological particles. The used cleaving agent solution is then examined by a tag-sensing instrument following possible concentration thereof for determining whether tag-bearing second particles have been removed. The tags may, for example, be radioactive, fluorescent, etc. A supplement is described, wherein the coated substrate is studied with a tag-sensing instrument before and after exposure of the coated substrate to the cleaving agent solution to help provide said determination.
All patients with CAC scores of zero \> 5 years previous will be invited to enroll and undergo repeat CAC scanning. This group will include all patients who continue to have a CAC of zero.
INDETERMINATE DOMAIN (IDD) genes encode plant-specific transcription factors containing a conserved IDD domain with four zinc finger motifs. Previous studies on Arabidopsis IDDs (AtIDDs) have demonstrated that these genes play roles in diverse physiological and developmental processes, including plant architecture, seed and root development, flowering, stress responses, and hormone signaling. Recent studies have revealed important functions of IDDs from rice and maize, especially in regulating leaf differentiation, which is related to the evolution of C4 leaves from C3 leaves. Moreover, IDDs in crops are involved in the regulation of agriculturally important traits, including disease and stress resistance, seed development, and flowering. Thus, IDDs are valuable targets for breeding manipulation. This review explores the role of IDDs in plant development, environmental responses, and evolution, which provides idea for agricultural application.
PURPOSE:To obtain a core-containing granule for oral administration having high strength of granule and excellent disintegrability, by coating a powdery scattering agent composed of a principal drug and a hydroxypropyl cellulose having low substitution degree to a core granule while spraying an aqueous binder. CONSTITUTION:Core granules of 14-80 mesh size (e.g. sucrose coated with corn starch) is coated with a powdery scattering agent composed of a principal drug (e.g. drug for central nervous system, circulatory system, respiratory system, digestive system or antibiotic substance) at room temperature while spraying an aqueous binder to the granules. The binder is e.g. granulated sugar or hydroxypropyl cellulose. The powdery scattering agent may be further compounded with an excipient, binder, disintegrant, stabilizer, etc. The obtained core-containing granule may be further subjected to coating, encapsulation, etc., to mask the taste or impart enteric or gastric solubility and prolonged drug action.