anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a cervical vertebra acupuncture pillow. The cervical vertebra acupuncture pillow comprises a pillowcase and a pillowfillow. The pillowcase is a rectangular cavity which is 25 centimeters long, 10 centimeters wide and 9 centimeters high. A closure zipper is arranged on one side of the pillowcase. The pillowfillow is a rectangular cavity which is 25 centimeters long, 10 centimeters wide and 9 centimeters high. The pillowfillow is used for filling the pillowcase. The central section of a upper surface on the pillowfillow is a concave arc shape. The cervical vertebra acupuncture pillow also comprises an inflatable airbag. The inflatable airbag is arranged on the upper surface of the pillowfillow. A number of independent small airbags are arranged in the inflatable airbag. Each small airbag is connected with a main airline which is connected with an air pump through a branch airline. All of the branch air lines are provided with an electromagnetic valve, an electromagnetic valve, an air pressure sensor, a storage used for storing the air pressure value of the small airbag and a controller connected with the air pressure sensor, the electromagnetic valve and the air pump. The cervical vertebra acupuncture pillow has the advantages of being convenient, comfortable, attractive, being capable of being unpicked, washed and disinfected and being capable of exposing the location of the acupuncture well, which is beneficial to be operated.
PURPOSE:A white cosmetic having improved storage stability, absorbing capacity of the skin, whitening and anti-sunburn effects free from side effects undesirable to the human body, comprising quercetin as an active ingredient. CONSTITUTION:A white cosmetic comprising 0.01-10wt% of a quercetin shown by the formula as an active ingredient. Exhibiting extremely controlling action of melanin formation, antioxidant action, ultraviolet light absorbing capacity, etc., quencetin has improved whitening and anti-sunburn effects. Because of the stability to pH, light, heat, etc. the cosmetic has improved keeping quality, and its oil solubility enables it to dissoble easily in an oil loyer, e.g., cream and to exhibit absorbing capacity of the skin. Quercetin is quite harmless to the human body and all the cosmetic raw materials have been available conventionally can be used directly.
The active comparator group was comprised of 15 patients who submitted to the routine expansion procedure with a bonded RME as anchorage in the maxillary arch. The Face mask was used.
For equity, parents or guardians of children in the usual diet arm will be given 2 bags of maize meal(4Kg) for family consumption instead of RUSF. All parents and carers in both arms will also receive standard nutritional advice as specified in the current WHO IMCI handbook.
The secondary purposes are to investigate the correlation between cervical region biomechanics and posture, functional exercise capacity, depression \&anxiety level,neck disability, cough severity. In accordance with this purposes, 17 patients with COPD who have Global Initiative for Chronic Obstruction Lung Disease (GOLD) stage 1-2-3-4, being clinically stable for 4 weeks and 17 healthy controls will be included ages\>40. Tests and questionnaires will be used in order to determine the severity of COPD and to evaluate posture. Photographical analysis in lateral and posterior views will be used for evaluation of cranioservical region static and dynamic biomechanics. To analyze of chest wall, radiographic evaluation will be performed. Goniometry will be used for evaluation dynamic craniocervical kinematic analysis. Cranioservical region muscle strength and endurance tests will be performed. Respiratory muscle strength tests and cough evaluation test will be performed. Neck disability index, cough evaluation test questionnare, beck depression and anxiety questionnares, Nordic Musculoskeletal questionnare will be used. 6 Minute Pegboard and Ring Test, 6 Minute Walk Test will be performed. According to the results to be obtained, relationship between cranioservical region biomechanics and posture will be investigated based on the severity of disease in patients with COPD. It will guide professional working in the field.
BACKGROUND: The cGAS-STING pathway emerges as a pivotal innate immune pathway with the potential to profoundly influence all facets of tumor initiation and progression. The prognostic significance and immunological role of cGAS-STING pathway-related genes (CRGs) in individuals diagnosed with bladder cancer (BLCA) have not yet been fully elucidated.
METHODS: Performed unsupervised cluster analysis to identify distinct clusters. Utilizing LASSO and multivariate Cox regression analysis to construct a prognostic risk model. The IMvigor210, GSE13507 and GSE78220 cohorts were utilized to explore the potential value of risk score in immune therapy response and survival prediction.
RESULTS: A risk model was developed utilizing four CRGs in order to forecast the overall survival (OS) of BLCA patients. The risk score to be a standalone risk factor, which was further corroborated by the external validation set obtained from the GEO database (GSE13507). We established an integrated nomogram that combined risk scoring and clinical information, exhibiting commendable clinical practicality in predicting the overall survival period of BLCA patients. It is noteworthy that risk score could differentiate tumor microenvironments among different risk groups and individuals who were more responsive to immunotherapy in IMvigor210 and GSE13507 cohorts. In vitro experiments, we noted an up-regulation of IRF3 and IKBKB upon the activation of the cGAS-STING pathway. Conversely, the activation of the cGAS-STING pathway resulted in a down-regulation of POLR3G and CTNNB1.
CONCLUSIONS: CRG risk model shows promise as a potential stratification approach for bladder cancer patients.
The various embodiments of the present invention provide an Internet-of-things (IOT) based system for health monitoring. The system comprising a wearable device, a local server, a computer readable medium and a central server. The wearable device comprises a plurality of physiological sensors and is connected to a set of IOT based devices. The wearable device is connected to the local server for controlling a plurality of household devices connected to the local server through IOT. The computer readable medium acts as an interface between a user device and a first responder device. The central server provides an interconnection between the user device and the first responder device and records a data exchange between the user device and the first responder device. -1-
Primary root canals(n=20) were instrumented using Fanta AFTM-Baby rotary system (Shanghai Fanta Dental Materials, SUNGO Certification Company Limited, London, England) at 350 rpm and 2 N cm torque. Four files were used sequentially in the following order; open file #17/0.08, #20/0.04 yellow, #25/0.04 red and #30/0.04 blue. The rotary files were used with an Endo-Mate DT endodontic motor (NSK, Tokyo, Japan) and EDTA gel 17% (Meta Biomed Co. Ltd, Chungbuk, Korea) was used before instrumentation.
Participants first utilized one drop of Refresh Optive MEGA-3 in each eye before taking lipid layer thickness measurements occurring at 15 minutes and 1 hour after instillation. After a washout period, they returned to repeat the testing using one drop of Refresh Optive before taking lipid layer thickness measurements.
Chronic Obstructive Pulmonary Disease (COPD) is one of the most common exacerbating, non-communicable diseases. It is the third leading cause of death worldwide, causing 3.23 million deaths in 2019. Given the above, there is an international need to develop appropriate strategies for its management. COPD affects both the physical and psychosocial well-being of patients. Studies have shown that anxiety, depression, lack of social support and poor financial status are associated with more frequent exacerbations, hospital readmissions, nonadherence to treatment and worse quality of life for patients. Therefore, socioeconomic and psychological factors play a critical role in COPD. The psychosocial support of patients with COPD it is likely to be an important method for improving their health status and therefore their quality of life. The aim of this PhD thesis is to assess the psychosocial status and the impact of psychosocial information-interventions in patients with COPD. For this purpose, a prospective study of mixed methodology design (questionnaires, interviews) as well as psychosocial interventions will be conducted in patients with COPD who are attended by Pulmonary Departments of Hospitals (Outpatient Clinics, Clinics), by Local Health Units (TOMY), Regional Clinics in the prefecture of Heraklion. Interventions will include counseling for 6 months/information about services, patient benefits, support, and patients will receive a relevant form. For the implementation of the study, they will use the investigative tools (questionnaires) for the patient's health status/quality of life (SF-12-CCQ), treatment adherence (TAI), mental status (PHQ-4 includes PHQ-2 for depression and GAD-2 for anxiety) and socioeconomic status (MSPSS, FAS). Then a qualitative part will take place with an interview. At the end of 6 months the participants will be asked to answer again the same questionnaires and a partially modified interview, so that the effectiveness of the psychosocial interventions they received. Their responses will be recorded and the results will be analyzed. This study is expected to contribute to a better management of patients with COPD.
BACKGROUND: Cardiovascular diseases (CVDs) stand as the foremost global cause of mortality, prompting a growing interest in using the potential of immune cells for heart injury treatment. This study aims to assess the causal association between immune cells and CVDs.
METHODS: A total of 731 immune cells were derived from a previously published genome-wide association study (GWAS), which included approximately 22 million genetic variants among 3,757 individuals of Sardinian ancestry. Genetic associations with atrial fibrillation (AF), heart failure, coronary artery disease, myocardial infarction and stroke were extracted from large-scale GWAS. A two-sample Mendelian randomization (MR) analysis was used to assess the causal association between immune cells and CVDs. Replication MR analysis based on FinnGen dataset and meta-analysis are sequentially conducted to validate causal relationships.
RESULTS: Collectively, genetically predicted 4 immune cell traits were associated with AF and 5 immune cell traits were associated with stroke. Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. Additionally, an elevated susceptibility to stroke was linked to an increase in the percentage of CD39+ resting Tregs and heightened CD27 expression on IgD- CD38+ cells. Conversely, a decreased susceptibility to stroke was associated with increased CD40 expression on monocytes, particularly on CD14+ CD16+ and CD14+ CD16- monocytes, with the latter two showing the most compelling evidence.
CONCLUSION: This study identified several immune cell traits that have a causal relationship with CVDs, thus confirming that immune cells play an important role in the pathogenesis of these diseases.
BACKGROUND: The English schools-based human papillomavirus (HPV) vaccination programme has the potential to eliminate HPV-related cancers if high uptake is achieved. However, unmet information needs among some parents may contribute to persisting lower uptake among minority ethnic groups. Through this study we aimed to understand the information needs of vaccine-hesitant, ethnically diverse parents during decision-making about the HPV vaccine for their adolescent child, to inform the future development of tailored communication materials.
METHODS: Recruitment was facilitated thorough healthcare and community organisations within London and the South West of England. Semi-structured interviews took place between April and August 2023. Thematic analysis was undertaken, assisted by NVivo software.
RESULTS: Of the 29 parents interviewed, the majority were mothers (79%), belonged to a minority ethnic group (88%), and had an adolescent child unvaccinated against HPV (72%). Five of the interviews were undertaken in the participants' primary language with translation support. Most parents interviewed had limited knowledge about the HPV vaccine and appeared conflicted as to whether vaccines could offer benefits to health. Misunderstanding around the potential of developing serious side-effects (e.g. fertility issues, developing cancer) were factors that could negatively impact decision-making by parents. Stigma associated with the sexual transmissibility of HPV did not always negatively impact decision-making. However, some parents chose not to vaccinate on the basis of perceptions of low risk and a preference to provide education about sexual behaviours to their adolescent child.
CONCLUSIONS: Tailoring communication materials to address misunderstandings could support informed decision-making by vaccine hesitant parents for their adolescent children to be vaccinated against HPV. Future communication materials about the HPV vaccine should highlight the benefits of protection against cancer to increase parents' motivation for protect their adolescent child; provide accurate convincing information in relation to the excellent safety profile; and emphasise the importance of providing HPV vaccine at the recommended age, all alongside communicating the universality and commonality of HPV infection.
TRIAL REGISTRATION: N/A.
Approximately 30 individuals whose loved ones are experiencing FEP and receiving services from three of the five FEP clinics (Encompass, Eagle, and AEGIS) will be recruited to participate in treatment as usual offered by their respective clinic. Participants will then be asked to complete the same battery of measures as the experimental group at baseline, 3-months, and 6 months.
Coronary microvascular dysfunction (CMD) is among pathophysiological states of significance in hypertrophic cardiomyopathy (HCM). The index of microcirculatory resistance (IMR) has been recognized as an indicator of CMD and considered of important prognostic value in various conditions. The angiography-derived index of microcirculatory resistance (angio-IMR) is a novel guidewire-free method to assess IMR and proved to have favourable correlation with it. In this study, patients who met the inclusion criteria were collected from two centers, and the angio-IMR of three coronary arteries was measured to monitor their microcirculation. Then, explore the prognostic value of the angio-IMR of the left anterior descending artery (LAD). At the same time combined with the sum of three coronary arteries' angio-IMR, analysis of its prognostic value. In conclusion, this study was designed to assess prognostic impact of CMD in HCM patients, using angio-IMR as a novel non-invasive assessment tool.
The invention relates to a propafenone hydrochloride sustained-release capsule and a preparation method thereof. The propafenone hydrochloride sustained-release capsule is prepared by filling sustained-release micro-tablets with the diameter of 2-3 mm, and has good dosage dispersion and uniformity. The micro tablets are composed of propafenone hydrochloride, a framework material, a lubricant and a diluent. The framework material is one or more of methyl cellulose, ethyl cellulose, hydroxypropyl methylcellulose and povidone; and a usage amount of the framework material is 1%-10%. The lubricant is one or more of sodium stearyl fumarate, magnesium stearate, micro-powder silica gel, talcum powder, calcium stearate and polyethylene glycol; and a usage amount of the lubricant is 0.1%-1.5%. The diluent is one or more of sucrose, mannitol, microcrystalline cellulose, lactose and polyethylene glycol; and a usage amount of the diluent is 2%-12%. According to the propafenone hydrochloride sustained-release capsule, the usage amount of a main drug is 77%-98%; and propafenone level in blood plasma reaches the maximum value 3-8 hours after drug delivery. The propafenone hydrochloride sustained-release capsule is stable in drug release and has a good sustained-release effect. An object of the invention is to provide a preparation method of the propafenone hydrochloride sustained-release capsule. The preparation method is simple in process, high in yield, good in stability and suitable for large-scale production.
This is a single-center, randomized controlled pilot clinical trial (n=20) assessing the efficacy, feasibility and safety of acupuncture in reducing the severity of chemoradiation-induced oral mucositis (CRIOM) in patients with oropharyngeal cancer. Participants will be randomized to receive either usual medical care or acupuncture treatment plus usual medical care once a week for 8 weeks coinciding with their chemoradiation treatments. The length of the study will be 16 weeks: 8 weeks of treatment and two follow up visits at 4 weeks and 8 weeks after radiation (weeks 12 and 16). All subjects will receive usual medical care in addition to the study intervention. The Oral Mucositis Daily Questionnaire for Head and Neck Cancer patients (OMDQ) will be used to assess patients' self-reported chemoradiation-induced mucositis severity at baseline (before 1st acupuncture session), and daily throughout the course of radiation, as well as at the 12 and 16 week follow up visits. At baseline, weekly during radiation therapy, and at the 12 and 16 week follow up appointments, patients will complete the Functional Assessment of Cancer Therapy (FACT-G), Esophagus Cancer subscale (ESC) QOL, and the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue subscale questionnaires. Oral mucositis will also be assessed objectively by a trained member of the research team using both the Oral Mucositis Assessment Scale (OMAS) and the National Cancer Institute- Common Toxicity Criteria for Adverse Events (NCI-CTCAE) v3.0 measurement scale once a week for the first two weeks of chemoradiation treatment, then twice a week during weeks three through seven, and additionally once during week 8 and once at the 12 and 16 week follow up visits. Twice weekly measurements correspond to peak severity of mucositis during weeks three to seven, based on previous reports in the literature. Patients will be given a weekly diary to record oral analgesic intake. Lastly, 8 milliliters of blood and a saliva sample will be taken from the subjects at baseline (before 1st acupuncture session), weekly through radiation treatment, and at the week 12 and 16 follow up visits to measure changes in proinflammatory cytokines concentrations.
Nintedanib 200mg twice daily days 2-21 every 21 days for 6 courses during simultaneous treatment with carboplatin-paclitaxel; afterwards in maintenance 200mg twice daily days 1-21 every 21 days. Treatment continues until progression or unacceptable toxicity.
Subjects in the Group were followed during the entire study period, from Day 0 up to study end 6 months post fourth dose vaccinationDuring Primary Phase (Study 101858), subjects in this group, aged 6-12 weeks at enrolment, received 3 doses of Menhibrix™ co-administered with Pediarix™ and Prevnar™ (at Day 0 and Months 2 and 4). During Fourth-Dose Phase (Study 102015), subjects primed with 3 doses of Menhibrix™ during the Primary Phase received one dose of Menhibrix™ and one concomitant dose of Prevnar™ at Month 10-13. During Primary Phase, Menhibrix™ was administered intramuscularly (IM) in the right upper thigh, and Pediarix™ and Prevnar™ IM in the left upper and lower thighs, respectively. During Fourth-Dose Phase, Menhibrix™ was administered by the same route and at the same site as during Primary Phase, and Prevnar™ was administered IM in the left upper thigh.
Medication Delivery System and Method Examples of the present application include an infusion device for controlling a medication delivery apparatus to deliver a pharmaceutical preparation to a patient, the infusion device comprising a processor and a memory storing instructions executable by the processor. The instructions include instructions to: determine, a number of infusion steps (?) that are to be performed within a time window, the time window comprising a first time window and a second time window, wherein a first number of infusion steps (?1) are to be performed within the first time window and a second number of infusion steps (?2) are to be performed within the second time window. To determine, for an infusion step of the first number of infusion steps (?1), a first infusion volume, using a cumulative delivery volume function. To determine, for an infusion step of the second number of infusion steps (?2), a second infusion volume, using a dose function. To control the medication delivery apparatus such that the first infusion volume of a fluid is expelled from the medication delivery apparatus during the infusion step of the first number of infusion steps (?1); and the second infusion volume of the fluid is expelled from the medication delivery apparatus during the infusion step of the second number of infusion steps (?2).
A complex salt of aluminium, penicillin and a p-aminobenzene sulphonamide is prepared by reacting a water-soluble salt of penicillin with a water-soluble salt of the p-aminobenzenesulphonamide and a water-soluble salt of aluminium in a solvent which is preferably water.  It is preferred to add a solution of the aluminium salt to mixed solutions of the penicillin salt and p-aminobenzenesulphonamide salt.  The temperature may be 0 DEG  to 100 DEG  C. but it is preferred to keep the temperature below 25 DEG C. and advantageously below 15 DEG  C. Preferred are compounds of formula Al(Pen)n(Sulph)3-n where Al represents a trivalent aluminium atom, Pen represents a monovalent radical of penicillin, sulph represents a monovalent p-aminobenzenesulphonamide radical and n represents a positive integer of less than three such as monopenicillin aluminium di - p - aminobenzenesulphonamide and di-penicillin aluminium mono-p-aminobenzenesulphonamide.  The proportions of penicillin and p - aminobenzenesulphonamide may be varied within the series disclosed by the above general formula while the aluminium remains constant.  A mixed-penicillin mixed-sulphonamide complex is possible, e.g. mono-penicillin G mono-penicillin - o - aluminium mono-sulphatiazole.  Specified penicillins are penicillins G, O, F, dihydro F, K and X.  Specified p-aminobenzene-sulphonamides are sulphamethazine, sulphacetamide, sulphamerazine, sulphadiazine, sulphapyridine, sulphathiazole, phthalylsulphathiazole and succinylsulphathiazole.  The penicillin water-soluble salts specified are those of sodium, potassium, calcium, barium, diethanolamine, 2-methyl-2-aminopropanol, methylamine, isopropylamine and ethanolamine.  The sulphonamide salts specified are those of sodium, potassium, calcium, diethanolamine, methylamine, 2-methyl-2-aminopropanol, isopropylamine and ethanolamine.  Many examples of specific compounds are given.