anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to the preparation of a chemical medicine preparation, which is a compound artemether methyl ether droping pill used for curing malaria. The present invention has the advantages that: 1. Serving as main ingredients, antimalarial lumefantrine and artemether are sufficiently dispersed by water-soluble auxiliary-ingredient polyethylene glycol or poloxamer, thus being favorable for absorbing the main ingredients. 2. The dropping pill preparation can be taken under tongue and also can be swallowed with very short disintegration (dissolve) time limit. And the invitro dissolve quantities are greatly improved and the peak value of the blood concentration can be reached rapidly, thus being beneficial to the improvement of the curative effect; 3. The main ingredients and the auxiliary ingredients are equably mixed at the temperature of 80 to 90 DEG C and insulated for some time, and then are dropped into methylsilicone oil or liquid paraffin at the temperature ranging from 5 to10 DEG C; 4. The method is simple in production process and short in production cycle. The cost can be decreased; 5. As the medicine is left in stomach for a short time or maybe the first-pass effect of the stomach can be avoided, so the generation of drug resistance and other side effects decreases.
Two physiotherapists will evaluate stroke patients' balance using the berg balance scale and the Tinetti balance test. Before the evaluation, patients will be informed about the mask, distance, and hygiene issues, which will be considered in the assessment. On the first day, information about the patient and the disease, filling in the patient data form, and face-to-face assessment will be made face to face with the patients. The next day, one synchronous and asynchronous tele-evaluation method will be applied. Evaluations will be made at the same time zone of the day, determined by the randomization method, one day apart. For the learning effect to not positively impact a technique in the assessments, the order of the checks applied to each will change. The first physiotherapist will conduct face-to-face interviews and evaluations in a clinical setting. In the meantime, necessary measures will be taken due to the pandemic. The synchronous tele-assessment will be evaluated online in real-time by the second physiotherapist. At the same time, the first physiotherapist will make their evaluations online without giving instructions during this evaluation. For asynchronous tele-assessment, a reference evaluation video will be sent to the patients. Relatives of the patients will be asked to watch this video, make the evaluation and take a video recording at the same time. Then, these video recordings will be evaluated separately by the first and second physiotherapists, and the results will be compared. Each assessment will take approximately 30 minutes. The test evaluation will be performed again. Asynchronous tele-evaluation videos will also be re-evaluated in 25% of individuals after ten days. This way, instead of having the patients repeat the same tests, the test will be repeated on the first test.
BACKGROUND: In this substudy of the Value of Gated-SPECT MPI for Ischemia- Guided PCI of non-culprit vessels in STEMI Patients with Multi vessel Disease after primary PCI trial after primary PCI we aim to assess if infarct size affects conventional measures of dyssynchrony at rest. Additionally, we explore if there is an independent correlation of stress-inducible ischemia with dyssynchrony at rest.
METHODS: The 48 patients with imaging at randomization were analyzed. Gated-single-photon emission computed tomography (SPECT) MPI with vasodilator stress and technetium-99m-labeled tracers was performed. The phase histogram bandwidth (HBW), phase SD, and entropy were obtained with the QGS software. Correlation between dyssynchrony at rest and infarct size and inducible ischemia was performed using the Spearman test.
RESULTS: According to normal database limits dyssynchrony parameters at rest were abnormal for men. In women only HBW was abnormal. Correlation between the summed rest score with dyssynchrony was significant only for entropy ( P  = 0.035). No correlation was observed for dyssynchrony and stress-induced ischemia.
CONCLUSION: Entropy, as a measure of dyssynchrony, has potential in the assessment of patients with STEMI and multivessel disease after primary PCI. Smaller residual myocardial scars in PCI-reperfused patients with STEMI may contribute to the lack of correlation between dyssynchrony at rest and infarct size and stress-induced ischemia, respectively.
NEW MATERIAL:The compound of formula (R1 and R2 are H or alpha-methyl- butanoyl; R3 is H, alpha-methylbutanoyl or isobutanyol). USE:An evacuant. PREPARATION:Seed of Ipomoea muricata (L) Jacq. is crushed, extracted with a lower alcohol preferably at normal temperature for 1-10 days and, if necessary, defatted with hexane, etc., and the solvent is distilled off. The extracted fraction is subjected to normal-phase column chromatography and then gel- filtration to remove foreign materials. The product is subjected further to normal-phase chromatography to obtain several fractions having different R1-R3, which are purified by high-performance liquid chromatography.
The present invention is directed to an effective HIV vaccine will most likely require the induction of strong T-cell responses, broadly neutralizing antibodies (bNAbs), and the elicitation of antibody-dependent cellular cytotoxicity (ADCC). Previously, we demonstrated the induction of strong HIV/SIV cellular immune responses in macaques and humans using synthetic consensus DNA immunogens delivered via adaptive electroporation (EP). However, the ability of this improved DNA approach to prime for relevant antibody responses has not been previously studied.Here, we investigate the immunogenicity of consensus DNA constructs encoding gp140 sequences from HIV-1 subtypes A, B, C and D in a DNA prime protein boost vaccine regimen. Mice and Guinea pigs were primed with single and multi-clade DNA via EP and boosted with recombinant gp120 protein. Sera were analyzed for gp120 binding and induction of neutralizing antibody activity. Immunization with recombinant Env protein alone induced low-titer binding antibodies with limited neutralization breath. In contrast the synthetic DNA prime protein boost protocol was induced significantly higher antibody binding titers. Furthermore, sera from DNA prime-protein boost groups were able to neutralize a broader range of viruses in a panel of tier 1 clade B viruses as well as multiple tier 1 clade A and clade C viruses. Further investigation of synthetic DNA prime + adaptive EP plus protein boost appears warranted.
The invention relates to the technical field of molecular biology and tumor marker medicine, in particular to SNORD60 serving as an endometrial cancer diagnosis marker and application thereof. An application of a molecular marker in preparing products for diagnosing endometrial cancer is disclosed, wherein the molecular marker is SNORD60, and the nucleotide sequence of the molecular marker is shown as SEQID No. 1. The marker shows high expression in human clinical endometrial cancer tissues and is specifically and highly expressed in human intimal cancer cell lines HEC-1B and Ishikawa. The invention provides application of SNORD60 in preparation of a medicine or a medicine composition for treating endometrial cancer. SNORD60 is used as a marker for endometrial cancer diagnosis, provides a molecular target for endometrial cancer treatment, and can be applied to preparation of antitumor drugs.
Antioxidants exert a paradoxical influence on cancer prevention. The latest explanation for this paradox is the different target sites of antioxidants. However, it remains unclear how mitochondria-targeted antioxidants trigger specific p53-dependent pathways in malignant transformation models. Our study revealed that overexpression of mitochondria-targeted catalase (mCAT) instigated such malignant transformation via mouse double minute 2 homolog (MDM2) -mediated p53 degradation. In mouse epithelial JB6 Cl41 cells, the stable expression of mCAT resulted in MDM2-mediated p53 degradation, unlike in catalase-overexpressed Cl41 cells. Further, we demonstrated that mCAT overexpression upregulated ubiquitin-specific protease 28 (USP28) expression, which in turn stabilized c-Jun protein levels. This alteration initiated the activation of the miR-200b promoter transcription activity and a subsequent increase in miR-200b expression. Furthermore, elevated miR-200b levels then promoted its binding to the 3'-untranslated region of protein phosphatase 2A catalytic subunit (PP2A-C) α-isoform mRNA, consequently resulting in PP2A-C protein downregulation. This cascade of events ultimately contributed to increased MDM2 phosphorylation and p53 protein degradation. Thus, the mCAT overexpression triggers MDM2/p53-dependent malignant transformation through USP28/miR-200b/PP2A-Cα pathway, which may provide a new information for understanding mitochondria-targeted antioxidants facilitate the progression to the tumorigenic state.
Vascular endothelial cells have important tissue-specific functions in fibrosis and regeneration. In the salivary gland, endothelial cells are required for proper development, but their roles within adult glands are largely unknown. To identify ligand-receptor interactions between endothelial cells and other cell types that may be important during fibrosis and regeneration, we used a reversible ductal ligation injury. To induce injury, a clip was applied to the primary ducts for 14 d, and to induce a regenerative response, the clip was subsequently removed for 5 d. To identify endothelial cell-produced factors, we used single-cell RNA sequencing of stromal-enriched cells from adult female submandibular and sublingual salivary glands. Transcriptional profiles of homeostatic salivary gland endothelial cells were compared to endothelial cells of other organs. Salivary gland endothelial cells expressed many unique genes and displayed the highest overlap in gene expression with other fenestrated endothelial cells from the colon, small intestine, and kidney. Comparison of the 14-d ligated, mock-ligated, and 5-d deligated stromal-enriched transcripts and lineage tracing revealed that endothelial cells retain their identity following ligation and recovery from injury. CellChat and NATMI were used to predict changes in ligand-receptor interactions from endothelial cells to other cells in response to ligation and deligation. CellChat and NATMI predicted that after ligation, interactions with fibroblasts, epithelial cells, and glial cells were increased, and following deligation, interactions with pericyte, glia, fibroblasts, and immune cells were increased. Some of the highest-ranked interactions predicted in ligated compared to mock endothelial cells were between glial cells via Col4a2-Cd93 and Jag2-Notch1, as well as epithelial cells via Pecam1-Cd38, while in deligated compared to ligated endothelial cells, the top interactions were between fibroblasts via Ntf3-Ntrk2, glial cells via Hspg2-Itgb1, and pericytes via Jam2-F11r. Understanding salivary gland endothelial cell signaling will inform future endothelial cell-based regenerative therapies.
PURPOSE: A composition and a health functional food containing a Pharbitidis Semen extract are provided to suppress the growth of renal cancer cells, and to induce renal cancer cell apoptosis. CONSTITUTION: A composition and a health functional food for treating renal cancer contain an organic solvent of Pharbitidis Semen as an active ingredient. The organic solvent is ethanol. The extract is prepared at 50 deg. C. for 24 hours, and dried and concentrated by a reduced pressure at 45 deg. C. The composition also contains a pharmaceutically acceptable carrier or diluents. [Reference numerals] (AA) Relative cellular viability
The invention relates to development of ganoderma lucidum bud functional foods and medicines, in particular to a preparation method of ganoderma lucidum bud protein with immunoregulatory activity. Extracting Ganoderma lucidum bud protein by ultrasonic extraction method, purifying by saturated ammonium sulfate, and separating by DEAE-52 column chromatography to obtain 3 components of Ganoderma lucidum bud proteins GLBP-0, GLBP-1 and GLBP-2. Particle size and potential show that GLBP-0 has the smallest Zeta potential and the largest particle size. Ultraviolet light shows a characteristic absorption of proteins at 280 nm. The infrared shows that GLBP-0 has characteristic absorption of typical amide bands of proteins, SDS-PAGE electrophoresis shows that GLBP-0 has 5 protein bands, is a mixed protein, has a molecular weight distribution of mainly 10-30kDa, and obtains that the GLBP-0 component has better activity. The prepared ganoderma lucidum bud protein has good activity and is expected to be used as a potential immunomodulator for developing functional foods and medicines.
Our previous research has confirmed differences in macroscopic and microscopic aspects between the imaging of lesioned dorsal root ganglia (DRG) in patients with postherpetic neuralgia (PHN) and healthy controls. Additionally, our study revealed that while lesioned skin localization is a classic method in clinical practice, there is still a certain rate of discrepancy with the lesioned DRG observed in magnetic resonance imaging (MRI). This suggests the significant value of MRI in diagnosing lesioned DRG in PHN patients. For patients with zoster sine herpete neuralgia, it is even more crucial to identify the lesioned DRG through MRI. However, due to the small size and varied morphology of DRG lesions, diagnosing lesioned DRG through MRI requires specialized knowledge in neuroanatomy and imaging, posing a challenge to clinical practitioners. Identifying lesioned DRG rapidly and accurately is crucial for interventional therapy, as it serves as an essential treatment target for neuropathic pain.

The YOLO (You Only Look Once) series of algorithms are currently widely used single-stage real-time object detection algorithms, including YOLOv1-YOLOv8. Due to their extremely high detection speed, they enable real-time object detection. YOLOv5 and YOLOv8 are now extensively employed in various applications such as autonomous driving, video surveillance, and object tracking. Moreover, the YOLO series is increasingly being applied in the medical field, including tumor and joint capsule lesion detection, demonstrating good accuracy, recall rates, and detection efficiency. This study aims to utilize the YOLOv8 algorithm to develop a fast and accurate object detection model, simultaneously evaluating its performance. It seeks to validate the feasibility and effectiveness of detecting lesioned dorsal root ganglia (DRG) in real-time postherpetic neuralgia using this model, providing a basis for early diagnosis for clinical practitioners and enabling rapid and precise localization of lesioned DRG.
<P>PROBLEM TO BE SOLVED: To solve the problems that, conventionally, in eyelash growth-promoting liquids, chemically synthesized agents as the active ingredients have been mostly uses as a mixture for almost all substances, being unsuitable to weak-skinned and/or sensitive-skinned persons, the effects are various, and the odors of them give mental stress on the relevant users.  <P>SOLUTION: An eyelash growth-promoting liquid is produced by the following process: Sho-chu (Japanese white distilled liquor) is mixed with Aloe arborescens Miller, pine bark, momordica charantia and Guinea pepper followed by sealing up the ingredients for a predetermined period to effect maturing until the Aloe arborescens Miller becomes brown from green. The resultant Sho-chu, after filtering off the Aloe arborescens Miller, the pine bark, momordica charantia and Guinea pepper, is mixed with grape fruit seed extract, jojoba oil, collagen, hyaluronic acid and ylang-ylang essential oil. Without these natural components' burdening on eyelashes, their active ingredients markedly promote eyelashes' growth, the jojoba oil, the hyaluronic acid and the collagen confine the active ingredients firmly, promoting eyelashes' growth further. Besides, as the ylang-ylang essential oil's scent gives no mental stress, the problems may be solved.  <P>COPYRIGHT: (C)2010,JPO&INPIT
A dental prosthesis includes polymeric material formed by heat curing a polymerizable composition having at least 5 percent by weight of at least one polymerizable Monomer having at least one acrylic moiety and a gram molecular weight of at least 200. The polymeric material is preferably formed by heat curing and has an unnotched izod impact strength of at least 2.5 and more preferably at least 3.0 ft.cndot. lb/in as measured by a Modified ASTM D256, and a flexural fatigue life of at least 20,000 flexes to failure at 0.1 inch deflection. Preferably the polymerizable monomer has a vapor pressure less than 5 mm Hg at 23°C. A method of making a denture is provided which includes molding and polymerizing the polymerizable composition to form a denture. Preferably the polymerizable composition includes polymerizable compounds made up of at least 5 percent by weight of the acrylic Monomer having a gram molecular weight of at least 300 and less than 5 percent by weight of Volatile compounds and less than 2 percent by weight of Low Molecular weight acrylic compounds having a gram molecular weight of less than 200.
Churches in the delayed treatment control condition will receive information on various health topics relevant to African Americans, such as strokes, lupus, sickle cell, etc. via text message during the first six months. Participants in this group will not receive any behavioral strategies designed to alter weight, physical activity, or diet during this time. They will receive the community health coach delivered church based weight loss intervention after 6 months.
The present invention relates to a novel anticoagulant protein mediated by a human placenta anticoagulant protein. The novel anticoagulant protein fuses a human placenta anticoagulant protein and polypeptide molecules, wherein the human placenta anticoagulant protein has affinity for activating blood platelets and has anticoagulant activity; the polypeptide molecules have fibrin resistance and fibrin guidance. The novel anticoagulant protein mediated by the human placenta anticoagulant protein simultaneously has bioactivity for resisting the generation of fibrin and resisting the activation of blood platelets, and has high affinity and selectivity for thrombus. The novel anticoagulant protein can be designed by protein engineering, and can be prepared by a genetic engineering method. The novel anticoagulant protein mediated by a human placenta anticoagulant protein has an application of being used as anticoagulant medicine for resisting thrombosis. The novel anticoagulant protein molecules of Gly-Pro-Arg-Pro-human placenta anticoagulant protein in a hirudin C terminal structural domain simultaneously have blood platelet affinity and bioactivity for thrombin inhibitors, and the Gly-Pro-Arg-Pro-human placenta anticoagulant protein is one kind of the novel anticoagulant protein. The present invention can be used as safe anticoagulant medicine with high efficiency.
The most common clinical toxicity of nevirapine is rash, which can be severe or life threatening [see Boxed Warning and Warnings and Precautions (5.2)]. Rash occurs most frequently within the first 6 weeks of therapy. Rashes are usually mild to moderate, maculopapular erythematous cutaneous eruptions, with or without pruritus, located on the trunk, face and extremities. In controlled clinical trials (Trials 1037, 1038, 1046 and 1090), Grade 1 and 2 rashes were reported in 13% of subjects receiving nevirapine compared to 6% receiving placebo during the first 6 weeks of therapy. Grade 3 and 4 rashes were reported in 2% of nevirapine recipients compared to less than 1% of subjects receiving placebo. Women tend to be at higher risk for development of nevirapine-associated rash [see Boxed Warning and Warnings and Precautions (5.2)].

Treatment-related, adverse experiences of moderate or severe intensity observed in greater than 2% of subjects receiving nevirapine in placebo-controlled trials are shown in Table 2.
In MeLiM minipigs, melanomas develop around birth, can metastasize, and have histopathologic characteristics similar to humans. Interestingly, MeLiM melanomas eventually regress. This favorable outcome raises the question of their malignancy, which we investigated. We clinically followed tens of tumors from onset to first signs of regression. Transcriptome analysis revealed an enrichment of all cancer hallmarks in melanomas, although no activating or suppressing somatic mutation were found in common driver genes. Analysis of tumor cell genomes revealed high mutation rates without UV signature. Canonical proliferative, survival and angiogenic pathways were detected in MeLiM tumor cells all along progression stages. Functionally, we show that MeLiM melanoma cells are capable to grow in immunocompromised mice, with serial passages and for a longer time than in MeLiM pigs. Pigs set in place an immune response during progression with dense infiltration by myeloid cells while melanoma cells are deficient in B2M expression. To conclude, our data on MeLiM melanomas reveal several malignancy characteristics. The combination of these features with the successful spontaneous regression of these tumors make it an outstanding model to study an efficient anti-tumor immune response.
Un-supervised exercise will be held 3 times a week for 60 minutes in the participant's home. Those who are unable to do a 60-minute session would instead complete it in two 30-minute sessions to reach the goal of exercising 150 minutes per week.
Method of utilizing ezetimibe-glucuronide (EZE-Gluc) as a diagnostic biomarker for a hepatic disorder is described herein. Non-alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease, affecting 25% people worldwide and 64 million people in the United States. The initial stage of NAFLD is simple steatosis, which is characterized by microvesicular fat deposition. Approximately 10% of patients with steatosis progress to non-alcoholic steatohepatitis (NASH), which has significant clinical implications. At present, a liver biopsy is the only definitive way of diagnosing patients with NASH. Therefore, an alternate method of delineating NASH patients from those with steatosis is needed. EZE-Gluc can provide a non-invasive, specific, and selective way of identifying patients with NASH.
The invention provides a composition consists based on garlic oil, garlic total polysaccharide and garlic total saponin as raw materials. The composition is integrated with water-soluble and fat-soluble effective components of garlic, so that the anti-cancer activity of the garlic is sufficiently played. The composition has excellent anti-tumor activity and has the effects of strengthening body resistance to eliminate pathogenic factors and reducing toxicity, has wide application prospect, and can be prepared into a tumor prevention medicament or health-care product with remarkable curative effect and small toxic or side effect. The invention also provides a method for preparing the composition. The method comprises the following steps: preparing the garlic oil from the garlic through double extraction; preparing garlic total polysaccharide from decoction dreg through water extraction and alcohol precipitation; and carrying out alcohol extraction and macroporous resin purification on the decoction dreg to obtain the garlic total saponin. The preparation method is simple to operate, low in cost and controllable in quality, realizes sufficient utilization of each part of garlic raw materials, and can be industrialized.
Participants will perform 6 weeks of face perception training (5 x 40 min sessions/week) that require discriminating faces based on external facial features (e.g., hair). As training progresses, the faces will become more challenging and the face sizes will vary.