anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
How stable a total knee replacement is depends on the correct and precise rotation of the femoral component. Abnormal femoral component rotation has been associated with numerous adverse conditions including knee instability, knee pain, scar tissue, and abnormal knee motion. Controversy exists, however, regarding the most favorable surgical technique to determine accurate femoral component rotation. Some doctors prefer a measured resection technique in which landmarks on the femur bone are used to determine where to place the femoral component. Others recommend a gap-balancing technique in which the femoral component is positioned by balancing the ligaments of the knee and placing it in the position where each ligament is equally strained.

The purpose of this study is to examine the impact of the measured resection and gap-balancing surgical technique on how the total knee replacement moves and patient knee outcome scores. Knee outcome scores are assessed from the responses given by patients to questions about outcomes associated with total knee replacement related to pain, symptoms, activities of daily living, sport and recreational function, and knee-related quality of life.
Cholestyramine for oral suspension, USP powder, the chloride salt of a basic anion exchange resin, a cholesterol lowering agent, is intended for oral administration. Cholestyramine resin is quite hydrophilic, but insoluble in water. Cholestyramine resin is not absorbed from the digestive tract. Nine grams of cholestyramine for oral suspension, USP powder contain 4 grams of cholestyramine resin. It is represented by the following structural formula:

Cholestyramine for oral suspension, USP powder contains the following inactive ingredients: acacia, anhydrous citric acid, D&C Yellow No. 10 Aluminum Lake, orange flavor (containing; modified food starch [with added corn syrup], maltodextrin, citric acid, silicon dioxide and natural tocopherols), propylene glycol alginate and sucrose.
PURPOSE: To review the safety and efficacy of Lap-re-Do technique in the treatment of large parastomal hernia.
METHODS: We retrospectively analyzed the recurrence and complications of 81 patients with large parastomal hernia who underwent Lap-re-Do technique in Huashan Hospital of Fudan University from May 2010 to December 2019. And the patients should be able to complete follow-up. With such criteria, we included 40 Lap-re-Do Keyhole patients and 41 Lap-re-Do Sugarbaker patients. Observation time was defined as time to recurrence, death, or last nonevent visit.
RESULTS: In large parastomal hernias, Lap-re-Do had a recurrence rate of 25.9% and complication rate of 16.0%, and reoperation rate of 9.9% during the average follow-up time of 41.1 ± 17.8 months. Recurrence rates were 40% (16/40) after Lap-re-Do Keyhole repair and 12.2% (5/41) after Lap-re-Do Sugarbaker repair. Complication rates were 12.5% after Lap-re-Do keyhole and 19.5% after Lap-re-Do Sugarbaker repair Re-operation rates referred to Lap-re-Do keyhole repair were 15% and Lap-re-Do Sugarbaker repair 4.9% during follow-up.The majority of reoperations were indicated by recurrence.
CONCLUSIONS: Large parastomal hernias are still difficult to be treated. Lap-re-Do Sugarbaker is recommended as an appropriate procedure to close the hernia ring, removing the lengthy colostomy, and effectively reduce recurrence and complication rates.
Infant will be booked for a 4-nut butter (Almond, Hazelnut, Walnut, and Cashew) graded and supervised OFC in the allergy clinical trials unit at the Murdoch Children's Research Institute. The nut butter contains a 1g dose of each nut protein in a total weight of 20g. Doses will be administered every 15minutes (1. Smear to inside of lip, 2.1/8 teaspoon, 3.1/4 teaspoon, 4.1/2 teaspoon, 5.1 teaspoon, 6.remainder of 20g nut butter paste) If challenge negative, infants continue home introduction of tree nuts as per written instructions provided. If challenge positive, infants will have additional SPT (for full tree nut panel) and single tree nut OFC as per protocol to determine tolerance/allergic status (and +/- home introduction recommendation) for each tree nut.
TDF has been selected for investigation as prophylaxis against HIV in high-risk men because of its unique pharmacologic profile. In addition to the convenience of being a once daily single tablet, TDF's safety profile is comparable to placebo among HIV infected persons, it has striking anti-HIV potency, and it has low potential for selection of resistant viruses. TDF is cleared from the body by the kidneys and is not metabolized by the liver. Therefore, TDF has limited potential to have pharmacokinetic interactions with other hepatically metabolized drugs. Each of these properties is necessary given the realities of the intended target populations. Moreover, initial prevention studies in simian models have provided encouraging results. Finally, the drug's sponsor is supportive of investigating the potential use of TDF as a preventive, as well as therapeutic agent, will provide TDF for the study, and is willing to make a good faith effort to make TDF available for public health use should it prove to be effective for HIV prevention.
STUDY OBJECTIVE: The manner in which an individual experiences a polycystic ovary syndrome (PCOS) diagnosis may affect prognosis and vary with age. This study aimed to evaluate and compare the diagnosis experiences of adolescent and young adult PCOS patients.
METHODS: PCOS patients from the same institution were divided into two groups according to age and clinic (adolescents diagnosed in the adolescent medicine clinic and young adults diagnosed in the obstetrics and gynecology clinic). Patients completed a questionnaire designed to assess the information and support received during diagnosis, their satisfaction with this information, existing concerns regarding PCOS symptoms, and support requirements.
RESULTS: Thirty-six patients were included in each group. Among the participants, 52.8% of the adolescents and 63.9% of the young adults reported that they had consulted more than one specialist before receiving a diagnosis. We found that 83.3% of adolescents and 63.9% of young adults were satisfied with their overall PCOS diagnosis experience. The highest ratio of information given in both groups was related to medical treatment (88.9% in both groups), and the lowest ratios were associated with emotional support (13.9% vs 5.6%). Irregular menstruation was reported to be the most disturbing concern in both groups (94.4% vs 86.1%), and the biggest difference between the two groups was related to body dissatisfaction, which was observed more in adolescents (33.3% vs 5.6%).
CONCLUSION: While overall diagnosis experiences and satisfaction levels were similar across both groups, we identified distinct differences that may warrant attention to address age-specific needs and preferences.
1,200,220. Germicides; dentifrices. UNILEVER Ltd. 4 Dec., 1967 [7 Dec., 1966], No. 55044/ 67. Headings A5B and A5E. A toothpaste, tooth powder or mouthwash comprises particles of a water-insoluble synthetic resin, inorganic abrasive or protein fibre having an average diameter of from 1-50 microns, which particles have been pretreated with a substantially water-insoluble germicide whereby the germicide is adsorbed on the particles. Germicidal compositions comprise particles of a water-insoluble synthetic resin, inorganic abrasive or protein fibre having an average diameter of from 1-50 microns and having a substantially water-insoluble solid organic germicide adsorbed thereon, the weight of the particles relative to the weight of the germicide being at least 5:1. Suitable germicides specified are hexachlorophene, halogenated salicylanilides (e.g. tribromosalicylanilide), halogenated carbanilides and tyrothricin.
During the 12-week intervention the participants will only take part in an online delivered EXCEL exercise class and will not have access to the ZI app. After completion of the 24-week test, the participants will be granted access to the ZI app.
PURPOSE:To read out effective picture information over a wide density range by changing the quantity of incident light in stages in accordance with the dynamic range of a photodetector system, dividing the picture information into proper density areas to read out the information and then synthesizing the divided pictures. CONSTITUTION:Optical beam scanning is adjusted so as to be executed twice during the sending of one picture element width of a film 9 and low density incident light and high density incident light are held in the 1st and 2nd scanning respectively. In each scanning, light corresponding to the density of a film is inputted to a photoelectric vonverter 12 and converted into an electric signal, which is logarithmically amplified, inverted and inputted to an A/D converter 15. The output of the converter 15 is switched by a switch 16 and stored in a low or high density data buffer 17 or 18. The output of the buffer 17 is compared with a constant by a comparator 21 and switched by a switch 23 to select data in each picture element. The value of low-density incident light can be calculated by adding a constant A corresponding to the difference between low density and high density to high-density data. Thus, effective picture information can be read out over a wide density range.
During the 12-week study period, patients were prescribed ziprasidone at 20 to 160 mg/day flexibly based on their effectiveness and tolerability. Fifty to one hundred percent of the past antipsychotic dose was maintained in the first week; during next 3 weeks, flexible dosing of 0-100% was used; then, ziprasidone was discontinued. This study included four visits: baseline, week 4, week 8, and week 12. Concomitant benzodiazepines (oral formula or injection) were allowed up to a dose of 4 mg of lorazepam-equivalents per day for anxiety and agitation.
Consistent with the potentially immunogenic properties of medicinal products containing peptides, administration of calcitonin salmon may trigger the development of anti-calcitonin antibodies. Circulating antibodies to calcitonin-salmon after 2 to 18 months of treatment have been reported in about one-half of the patients with Paget's disease in whom antibody studies were done. In some cases, high antibody titers are found; these patients usually will have a loss of response to treatment [see Warnings and Precautions (5.4)]. 

The incidence of antibody formation is highly dependent on the sensitivity and specificity of the assay. Additionally, the observed incidence of a positive antibody test result may be influenced by several factors, including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. For these reasons, comparison of antibodies among different calcitonin-salmon products may be misleading.
The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a personalized treatment plan may become a breakthrough point. On this basis, the concept of "Humanistic Health Management" (HHM) is proposed. This concept is a healthcare plan that focuses on self-health management, providing an accurate and comprehensive evaluation of individual lifestyle habits, psychology, and health status, and developing personalized and targeted comprehensive cancer prevention and treatment plans. This review will provide a detailed explanation of the relationship between psychological status, dietary, and exercise habits, and the regulatory mechanisms of cancer. Intended to emphasize the importance of HHM concept in cancer prevention and better prognostic efficacy, providing new ideas for the new generation of cancer treatment.
Falling Asleep During Activities of Daily Living and Somnolence

Patients taking SINEMET alone or with other dopaminergic drugs have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (includes operation of motor vehicles). Road traffic accidents attributed to sudden sleep onset have been reported. Although many patients reported somnolence while on dopaminergic medications, there have been reports of road traffic accidents attributed to sudden onset of sleep in which the patient did not perceive any warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event. Sudden onset of sleep has been reported to occur as long as one year after the initiation of treatment.

Falling asleep while engaged in activities of daily living usually occurs in patients experiencing pre-existing somnolence, although some patients may not give such a history. For this reason, prescribers should reassess patients for drowsiness or sleepiness especially since some of the events occur well after the start of treatment. Prescribers should be aware that patients may not acknowledge drowsiness or sleepiness until directly questioned about drowsiness or sleepiness during specific activities. Patients should be advised to exercise caution while driving or operating machines during treatment with SINEMET. Patients who have already experienced somnolence or an episode of sudden sleep onset should not participate in these activities during treatment with SINEMET.

Before initiating treatment with SINEMET, advise patients about the potential to develop drowsiness and ask specifically about factors that may increase the risk for somnolence with SINEMET such as the use of concomitant sedating medications and the presence of sleep disorders. Consider discontinuing SINEMET in patients who report significant daytime sleepiness or episodes of falling asleep during activities that require active participation (e.g., conversations, eating, etc.). If treatment with SINEMET continues, patients should be advised not to drive and to avoid other potentially dangerous activities that might result in harm if the patients become somnolent. There is insufficient information to establish that dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living.
In the present invention, an inspection image storage unit 28 stores a plurality of inspection images having imaging time information. An audio processing unit 32 recognizes audio input to a microphone 17, and extracts opinion-related information. An extracted information storage unit 34 stores the extracted opinion-related information in association with time information of the audio input to the microphone 17. A grouping processing unit 74 divides the plurality of inspection images into one or more image groups on the basis of the imaging time information. An association processing unit 76 associates, on the basis of the audio time information, the opinion-related information stored in the extracted information storage unit 34 with an image group. When a user selects one inspection image, an opinion selection screen generation unit 68 generates a screen for displaying the opinion-related information associated with the image group that includes the selected inspection image.
1. Obtain a Baker-Flex Aluminum Oxide coated, plastic TLC plate, #1 B-F, pre-cut to 2.5cm x 7.5cm.
  2. Dry the plate or plates at 100°C for 1 hour and store in a desiccator. Remove pre-dried plate from the desiccator just prior to use.
  3. Apply 1 drop of ethanol* using a 1 mL syringe with a 22 to 26 gauge needle, 1.5cm from the bottom of the plate. THE SPOT SHOULD NOT BE ALLOWED TO DRY.
  4. Add 2 drops of Technetium Tc 99m Sestamibi solution, side by side on top of the ethanol* spot. Return the plate to a desiccator and allow the sample spot to dry (typically 15 minutes).
  5. The TLC tank is prepared by pouring ethanol* to a depth of 3 to 4 mm. Cover the tank and let it equilibrate for ~10 minutes.
  6. Develop the plate in the covered TLC tank in ethanol* for a distance of 5 cm from the point of application.
  7. Cut the TLC plate 4 cm from the bottom and measure the Tc 99m activity in each piece by appropriate radiation detector.
  8. Calculate the % Tc 99m Sestamibi as:



*The ethanol used in this procedure should be 95% or greater. Absolute ethanol (99%) should remain at ≥ 95% ethanol content for one week after opening if stored tightly capped, in a cool dry place.
Participants will receive placebo vaccine at Day 0. They will receive the rDEN2Δ30-7169 vaccine at Day 270.
<P>PROBLEM TO BE SOLVED: To provide a new percutaneous administration apparatus, more specifically, to provide a percutaneous administration apparatus having micro-protrusions for a percutaneous drug delivery system (DDS).  <P>SOLUTION: The percutaneous administration apparatus 1 is provided with a substrate 2 and a plurality of protrusion parts 3 provided on the substrate. The main component of the protrusion part is a sugar or biodegradable polymer, and the height of the protrusion part is 10 μm to 3 μm. The tip of the protrusion part is flat, round, or flat and furthermore having a plurality of microprotrusions. Even if the protrusion parts do not penetrate the inside of a stratum corneum, only when the skin can be stretched, protection property of the skin can be degraded, so that a compound such as cosmetic, medicine, sugars stuck to or included in the protrusions can be administered.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The present invention relates to an external application medicine for treating many kinds of gynecological diseases, namely Fuyanyu. An NO. 1 medicinal powder capsule mainly treats many kinds of gynecopathy of vulvitis, vaginitis, cervical erosion, cervicitis, etc., and comprises traditional Chinese medicines of raw pinellia tuber, bleached pinellia tuber, common andrographis herd, vietnamese sophora root, arnebia root, climbing groundsel, giant knotweed rhizome, solanum nigrum, common cnidium fruit, dried alum and borneol. An NO. 2 capsule of suppository mainly treats early cervical carcinoma and metaphase cervical carcinoma and comprises traditional Chinese medicines of rattlebox, rhizoma sparganii, rhizoma zedoariae, edible tulip, honey-fried arsenic trioxide, realgar, common cnidium fruit, sodium tetraborate decahydrate, moschus, dried alum, borneol and corium stomachium galli. The present invention has a healing rate of more than 99% on early gynecological cancer and various kinds of phlogosis.
BACKGROUND: Little attention has been given to the risk of high-risk human papillomavirus (hr-HPV) infection and cervical precancerous lesions among female migrant head porters (kayayei) in Ghana, as a vulnerable group, and to promote cervical screening in these women. This pilot study aimed to determine the prevalence of hr-HPV infection and cervical lesions among kayayei in Accra, the capital of the Greater Accra Region of Ghana and to describe our approach to triaging and treating these women.
METHODS: This descriptive cross-sectional cohort study involved the screening of 63 kayayei aged ≥ 18 years at the Tema Station and Agbogbloshie markets in March 2022 and May 2022. Concurrent hr-HPV DNA testing (with the MA-6000 platform) and visual inspection with acetic acid (VIA) was performed. We present prevalence estimates for hr-HPV DNA positivity and VIA 'positivity' as rates, together with their 95% confidence intervals (CIs). We performed univariate and multivariable nominal logistic regression to explore factors associated with hr-HPV infection.
RESULTS: Gross vulvovaginal inspection revealed vulval warts in 3 (5.0%) and vaginal warts in 2 (3.3%) women. Overall, the rate of hr-HPV positivity was 33.3% (95% CI, 21.7-46.7), whereas the VIA 'positivity' rate was 8.3% (95% CI, 2.8-18.4). In the univariate logistic regression analysis, none of the sociodemographic and clinical variables assessed, including age, number of prior pregnancies, parity, past contraceptive use, or the presence of abnormal vaginal discharge showed statistically significant association with hr-HPV positivity. After controlling for age and past contraceptive use, only having fewer than two prior pregnancies (compared to having ≥ 2) was independently associated with reduced odds of hr-HPV infection (adjusted odds ratio, 0.11; 95% CI, 0.02-0.69).
CONCLUSION: In this relatively young cohort with a high hr-HPV positivity rate of 33.3% and 8.3% of women showing cervical lesions on visual inspection, we posit that kayayei may have an increased risk of developing cervical cancer if their accessibility to cervical precancer screening services is not increased.
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles, and nucleic acid-protein complexes. The invention provides methods of assessing microvesicles in a biological sample. The invention also provides an aptamer to a microvesicle surface antigen. The aptamer may be used for therapeutic purposes.
1390131 Scented coatings G WILBERT and T BROWN 16 Feb 1972 [20 Feb 1971] 7233/72 Heading B2E [Also in Division C3] A polymer is coated with a polymer or copolymer in an aqueous or non aqueous emulsion which, contains from 1% to 45% by weight of an essential oil. The polymer or copolymer of the emulsion may be polyethylene-styrene, polymaleic anhydride, vinyl acetate-ethylene copolymer, vinyl latex, chlorinated polyolefin, butadiene-acrylonitrile copolymer, a vinyl chloride-acrylic latex copolymer, or a mixture thereof with polyethylene in emulsion in a polymer wt. ratio of 5:1 to 1:5 or it may be an ethylene-styrenemaleic anhydride copolymer or polyethylene alone. The emulsion may be anionic or non- ionic and contain fillers, which may be preimpregnated with the oil, such as diatomaceous earth, calcium silicate, aluminium silicate, montimorrilonite, bentonite, fullers earth, Al 2 O 3 -SiO 2 , talc, SiO 2 , CaCO 3  or mixtures thereof. An aqueous emulsion of an adhesive may be mixed with the polymer emulsion in the range ratio with respect to the polymer or copolymer of 10:1 to 1:10 by weight. Oils mentioned are rose oil, carnation perfume oil, and oils having the fragrance of grape, strawberry, peach, apple spice, lemon, orange, cucumber, pine, jasmine, and the oils are mixed with antioxidants and a u.v. light absorber before addition to polymer emulsions. The oil containing emulsions are preferably applied to part of the surface of film formed, injection moulded or cast polyethylene flower petals or artificial fruits made from plastisols such as those containing polyvinyl chloride. The substrates may be optionally coated with an adhesive sub layer such as nitrile latex, vinyl latex, vinyl-acetate-ethylene copolymer or chlorinated polyolefins.