anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention comprises pyridyl-(2)-lower alkyl guanidines in which the lower alkyl radical separates the pyridine nucleus from the guanido group by 2 to 7 carbon atoms, or an acyl derivative, a quaternary ammonium compound or an acid addition salt thereof and their preparation by reacting a pyridyl-(2)-lower alkylamine or a salt thereof with an S-lower alkyl-isothiourea or a salt thereof and, if desired, acylating the product or forming the quaternary ammonium compound or acid addition salt.  (By "lower" is meant containing 1-7 carbon atoms).  Acyl derivatives are those of organic carboxylic acids, such as acetic, propionic, pivalic, dichloracetic, trifluoracetic, glycollic, methoxyacetic, cyclopentylpropionic, acrylic, benzoic, hydroxybenzoic, aminobenzoic, 1- or 2-naphthoic, nicotinic, isonicotinic or 2-furancarboxylic acids.  Quaternary compounds are derived from the esters of lower alkanols and aralkanols.  The guanidino group may be substituted, especially by aliphatic hydrocarbon radicals.  Pyridyl-(2)-lower-alkylamines are prepared by reduction of the corresponding alkyl cyanide. Pyridyl-2-ethylamine may also be prepared by reacting 2-vinylpyridine with phthalimide and splitting the N-substituted phthalimide with hydrazine.ALSO:Pharmaceutical compositions comprise pyridyl-(2)-lower alkyl guanidines in which the lower alkyl radical separates the pyridine nucleus from the guanido group by 2-7 carbon atoms or their acyl derivatives, quaternary ammonium or acid addition salts in admixture or in conjunction with a pharmaceutically suitable carrier. "Lower alkyl" groups contain 1-7 carbon atoms; the guanido radical may be substituted by an aliphatic hydrocarbon radical; acyl derivatives are prepared from organic acids acyl derivatives are prepared from organic acids such as acetic, propionic, pivalic, dichloracetic, trifluoracetic, glycollic, methoxyacetic, cyclopentylacetic, acrylic, benzoic, aminobenzoic, hydroxybenzoic 1- or 2-naphthoic nicotinic, isonicotinic or 2-furan-carboxylic acids; quaternary ammonium salts from esters of lower alkanols or aralkanols; and acid addition salts from inorganic and organic acids. Compositions may be in the form of tablets, dragees, capsules, solutions, suspensions or emulsions for enteral or parenteral administration.  The compositions may contain other therapeutically useful substances.  The compounds are hypotensive agents.
FIELD: medicine, stomatology. SUBSTANCE: composition represents a double-component caries-dissolving liquid in which one of the components consists of sodium hypochlorite, and another one consists of a substance capable to decrease aggressive influence of sodium hypochlorite upon mucous membranes. Said component is a gel-like one consisted of a gelatinous substance mixed with one or more amino acids. Said composition provides pain-free treatment of caries and requires no investments into expensive equipment. EFFECT: higher efficiency. 5 cl
Systemic immune responses caused by chronic hypercholesterolaemia contribute to atherosclerosis initiation, progression and complications1. However, individuals often change their dietary habits over time2, and the effects of an alternating high-fat diet (HFD) on atherosclerosis remain unclear. Here, to address this relevant issue, we developed a protocol using atherosclerosis-prone mice to compare an alternating versus continuous HFD while maintaining similar overall exposure periods. We found that an alternating HFD accelerated atherosclerosis in Ldlr-/- and Apoe-/- mice compared with a continuous HFD. This pro-atherogenic effect of the alternating HFD was also observed in Apoe-/-Rag2-/- mice lacking T, B and natural killer T cells, ruling out the role of the adaptive immune system in the observed phenotype. Discontinuing the HFD in the alternating HFD group downregulated RUNX13, promoting inflammatory signalling in bone marrow myeloid progenitors. After re-exposure to an HFD, these cells produced IL-1β, leading to emergency myelopoiesis and increased neutrophil levels in blood. Neutrophils infiltrated plaques and released neutrophil extracellular traps, exacerbating atherosclerosis. Specific depletion of neutrophils or inhibition of IL-1β pathways abolished emergency myelopoiesis and reversed the pro-atherogenic effects of the alternating HFD. This study highlights the role of IL-1β-dependent neutrophil progenitor reprogramming in accelerated atherosclerosis induced by alternating HFD.
1. Technical Result Increase in efficiency of atherosclerosis treatment.         2. Essence Hypocholesterolemic sugar-substituted 2-azetidinones are dislcosed, as well as a method of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and/or introducing the combination thereof, cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.         3. Field of Application Medicine.
A method for nutritional counseling consists of the following steps. First, a user is allowed to connect remotely over a network. Next, baseline personal information is received from a user. The user is then provided with nutritional guidelines over the network connection in accordance with the baseline personal information. Once the nutritional guidelines are established, food consumption information is received over the network connection from the user, and preferably logged into a food diary. The received food consumption information is analyzed in accordance with the nutritional guidelines, and dietary feedback is provided to the user over the network connection in accordance with the performed analysis.
The potato, being an underground vegetable crop, faces consistent threats from soil- and tuber-borne fungal and bacterial pathogens. Black scurf and stem canker disease caused by the fungal pathogen Rhizoctonia solani Kuhn is a critical global concern in the potato cultivation system. In this study, we evaluated the disease mitigation potential of five systemic acquired resistance-inducing chemicals viz., salicylic acid, jasmonic acid, β-aminobutyric acid, γ-aminobutyric acid and hydrogen peroxide (H2O2). Two common methods, tuber dipping and foliar spray, were utilized in this experiment to evaluate pathogen inhibition on inoculated tubers. The results revealed that all the systemic acquired resistance inducing chemicals were effective in disease suppression in a concentration-dependent manner compared to an inoculated control. Significant differences (P < 0.005) were evident among the various treatment combinations, with salicylic acid being the most effective in alleviating black scurf disease. Maximum reduction in disease incidence compared to the control was observed with salicylic acid (57.89% and 73.68%), followed by jasmonic acid (52.63% and 65.78%) and H2O2 (49.99% and 60.52%) under the tuber dipping treatment combinations. Whereas, in the foliar application, the maximum reduction in disease incidence compared to the control was observed with salicylic acid (44.73 and 63.15%), followed by jasmonic acid (42.10 and 60.52%) and H2O2 (39.46 and 52.63%). The tuber dipping treatments were significantly more efficacious (P < 0.005) compared to foliar spray for all treatment combinations. The biochemical analysis of defense-related enzymes and metabolites demonstrated the induced resistance activation under these treatments. The activity of peroxidase, polyphenol oxidase, and phenyl ammonia-lyase was significantly higher in treated tubers as compared to inoculated and uninoculated control. The total phenol content was also elevated in treated tubers as compared to the respective control. Altogether, these resistance-inducing chemicals can be successfully included in integrated disease management programs.
PURPOSE:To obtain the titled cosmetic having peripheral vasodilating action, blood flow increasing action and metabolic activity promoting action and exhibiting excellent effect to prevent falling off of hair, by compounding adenosine triphosphate or its salt. CONSTITUTION:The objective cosmetic is produced by compounding adenosine triphosphate or its salt in combination with a surfactant, an oil, a moisture- retainer and/or thickener, etc., and, as necessary, a preservative, an ultraviolet absorber, a perfumery, etc. The base medium for the cosmetic is hydrated alcohol or water. The amount of the adenosine triphosphate to be compounded is 0.0001-5wt.%, preferably 0.001-3wt.%. The pH of the adenosine triphosphate is preferably adjusted to 6-8 with a neutralizing agent such as ammonia or sodium hydroxide from the viewpoint of stability. The preventive effect of the active component can be further improved by the combined use of a hair- tonic component such as carpronium chloride.
The present invention consists in a composition of products resulting from Mexican herbs, from a plant commonly known as tree chrysamtemum, (Montanoa grandiflora montanoa bipinnatitida), which is intended to accelerate the healing process, the superficial tissue repair in ulcers with vesicular compromise originated by pressure or diabetic or anastomotic causes, the use of the invention being indicated in acute or chronic diseases mainly in diabetic patients. The product may be applied as a liquid solution, ointment, powder or in greasy sterile and humid forms with the healing product. The preparation of the healing solution includes the following products: 50 g of fresh leaves and 50 g of stalks of the plant, 1000 ml of distilled water and 500 ml of ethanol at 50%. The preparation of the semisolid presentation (ointment) includes the following products: 45 g of virgin wax, 45 cc of vegetable oil and 45 cc of the extract in liquid presentation. The powder presentation includes the foll owing products: 100 g of leaves and 100 g of stalks of the plant, 50 g of rice starch and 50 g of talc. The humid greases are prepared with the following ingredients: each sterile gauze is wet with 2ml of the healing solution.
Participants with PD-L1 Tumor Proportion Score (TPS) ≥ 50% receive Pembrolizumab 200mg intravenous (IV) for one dose alone, beginning on cycle 1 day 1 (C1D1). On Cycle 2 Day 1 (C2D1), participants receive Pembrolizumab 200mg intravenous (IV) once every 3 weeks (Q3w) and Sitravatinib 100mg PO (by mouth) daily.
OBJECTIVE: Unruptured posterior communicating artery (Pcom) aneurysms cause oculomotor nerve palsy (ONP). However, the time course of recovery after aneurysm repair remains unclear. We aimed to evaluate the ONP course after clipping and coiling for unruptured Pcom aneurysms.
METHODS: We retrospectively reviewed the medical records of 25 consecutive patients with ONP due to unruptured Pcom aneurysms, undergoing aneurysm repair at our institution during 2010-2022. We analyzed the clinical data, angiographic results, and surgical complications. The time to ONP recovery was evaluated using the Kaplan-Meier method.
RESULTS: This study included 14 patients undergoing surgical clipping and 11 undergoing endovascular coiling. The two groups exhibited no significant differences in complete or partial ONP percentage or in symptom presentation (ptosis, diplopia, ocular paralysis, pupillary light reflex disorder, or mydriasis). All patients achieved complete or partial recovery during the follow-up period. The median time to partial or complete improvement in ONP was significantly shorter for clipping compared to coiling (2 days vs. 33 days; P = 0.009). Preoperative partial and complete ONP were stratified; clipping improved significantly earlier than coiling in the complete ONP group (P = 0.010). In the early treatment group (based on the median duration of treatment), clipping resulted in earlier improvement than coiling (P = 0.014). In the small aneurysm group (based on the median of the aneurysm maximum diameter), clipping resulted in earlier improvement than coiling (P = 0.005).
CONCLUSION: In ONP caused by an unruptured Pcom aneurysm, clipping may provide faster recovery than coiling, particularly in cases of early onset, complete palsy, and small aneurysms.
Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evaluation of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents.
Acupuncture pretreatment (AP) has a good skeletal muscle protective effect. The present study investigated whether acupuncture pretreatment could improve ultrastructural changes and skeletal muscle inflammation in exercising skeletal muscle injury. Eighty-eight male SD rats were randomly divided into a blank group (C), an exercise group (E), and an acupuncture pretreatment group (AP). Among them, the E and AP groups were divided into five subgroups of 0h, 12h, 24h, 48h, and 72h according to the extraction time after exercise, with 11 groups and eight rats in each group. The study involved simulating skeletal muscle injury caused by intermittent downhill running centrifugal exercise. The researchers used various methods to observe changes in mitochondrial structure and cGAS-STING-NF-κB p65 protein content of classical inflammatory response signaling pathway. These methods included transmission electron microscopy to observe skeletal muscle, Western Blot to detect changes in protein content, and reverse transcription polymerase chain reaction (RT-qPCR method) to detect cytoplasmic mtDNA gene fragment ND1, D-LOOP and cGAS-STING- NF-κB p65 protein RNA. The aim was to investigate the changes in NF-κB p65 protein RNA. Changes in NF-κB p65 protein RNA content and mtDNA gene fragment ND1 and D-LOOP content; changes in serum IL-8 and IFN-β content were detected by enzyme-linked immunosorbent assay (ELISA); WB, RT-qPCR, ELISA assays aimed to study the skeletal muscle injury and mitochondrial structural damage in group E relationship skeletal muscle tissue level, cytoplasmic mtDNA fragment gene ND1, and D-LOOP content in skeletal muscle tissue of group E. In comparison to group C, the levels of cGAS-STING-NF-κB p65 protein expression and mRNA, and the serum levels of IL-8 and IFN-β were significantly higher in group E . However, the acupuncture pretreatment group (AP) reduced the extent of damage to skeletal muscle mitochondria and the levels of cytoplasmic mtDNA fragment genes ND1 and D-LOOP. Also, the high expression of cGAS-STING-NF-κB p65 protein, mRNA, and the levels of IL-8 and IFN-β were inhibited in the AP group. The results indicated that AP ameliorated exercise-induced skeletal muscle injury and reduced skeletal muscle inflammation produced after centrifugal exercise. This was achieved by inhibiting the overexpression of the cGAS-STING-NF-κB signaling pathway.
Cognitive disorders continue to be a common complication of HIV disease even though potent antiretroviral drugs can reduce HIV below detectable levels and restore immune function. Concentrations of most antiretrovirals in the nervous system are only a fraction of concentrations in blood. As a result, HIV can continue to be present in the nervous system when it is below detection in blood. A recently approved drug, raltegravir, reaches therapeutic concentrations in cerebrospinal fluid and may be effective at controlling HIV replication in the primary target cells in the brain, macrophages and microglia. Based on this, raltegravir may be a particularly effective drug for treating HIV disease in the nervous system. The purpose of this study is to determine the effects of raltegravir in the nervous system by measuring HIV in the CSF (via lumbar puncture, also known as spinal taps) before and after initiation of raltegravir-containing antiretroviral therapy. CSF is an accessible fluid that provides a window into brain processes, including HIV replication and inflammation. The potency of raltegravir will be estimated by calculating the change in HIV viral load in CSF over time. These changes will be compared to those following initiation an efavirenz-containing regimen in a separate group of individuals. Two additional drugs (tenofovir disoproxil fumarate, emtricitabine) will be combined with either raltegravir or efavirenz. Neuropsychological performance, mood, sleep and quality of life assessment will also be compared. Participants will be randomly assigned to either raltegravir- or efavirenz-containing therapy.
Group 1: sentinel lymph node procedure with or without select removal of clipped (clinically involved) lymph nodes. Patients who have more than 5 sentinel lymph nodes removed will be stratified into group 2.
All subjects eligible for inclusion in this study receive usual care physiotherapy as prescribed by the physician. The number of treatment sessions and content of physiotherapy treatment sessions will depend on the diagnosis and needs of the individual patient. This study will not interfere with the content of the usual care physiotherapy treatment. Patients in the control group will receive an accelerometer, measuring PA, which is applied by the physiotherapist during the first treatment. They receive no other additional intervention. Usual care physiotherapy sessions will take approximately 20-30 minutes per session.
FIELD: biochemistry, food and pharmaceutical industry. SUBSTANCE: invention describes the use of oligomeric proanthocyanidins as regulator of acetaldehyde metabolism in mammal body in the process of oxidation of ethyl alcohol. Invention describes also agent containing indicated regulator of acetaldehyde metabolism and liquor comprising ethyl alcohol and effective amount of oligomeric proanthocyanidins. Invention provides reduction of acetaldehyde concentration in body in massive oxidation of ethyl alcohol by effect on alcohol dehydrogenase activity and softening the damage effect of acetaldehyde on body. EFFECT: valuable properties of regulator. 4 cl, 2 tbl
OBJECTIVES: To assess the risk variables related to the types of candidemia for each patient, who was admitted into the intensive care unit regardless of the patient with or without complete diagnosis of COVID-19, during the period of March 2019 to December 2022.
METHODS: The evaluation comparison of demographic and clinical data of COVID-19 positive and negative patients with candidemia confirmed in blood, 113 cases were assessed. Variables such as gender, age, age of hospitalization, history of hospitalization, concurrently infection, The acute physiology and chronic health evaluation-II scores, comorbidity checking, intubation, central venous catheter use, parenteral nutrition use, steroid use, antibiotic use, lymphopenia, and laboratory variables were evaluated. Candida species distribution, antifungal susceptibility in blood culture were determined.
RESULTS: Coronavirus disease-19 was present in 62.8% of cases confirmed candidemia, and these cases were significantly different from COVID-19 negative cases. Significance was found in more intubation, central venous catheter use, parenteral nutrition, and steroid therapy in Group 2. There was no significance with species distribution and associated infection. In total, COVID-19 positive had higher hemoglobin, aspartate aminotransferase, alanine transaminase, and white blood cell levels, which may be associated with the possibility of revealing and controlling candidemia.
CONCLUSION: Candida albicans and Candida Parapsilosis (C. parapsilosis) are the species seen in infected COVID-19 patients, while C. parapsilosis and Candida tropicalis are found in non-COVID-19 ones. Risk factors were intubation, parenteral nutrition, central venous catheter, and steroid in the COVID-19 group.
Age and gender specific growth charts for Indian children with Down syndrome (DS) based on longitudinal data have not been published. To establish percentile growth charts for DS children inhabiting northwestern parts of India, body weight and length/height of 1125 (Male: 752, Female: 373) children with DS aged <1 month to 10 years, enrolled from the "Genetics Clinic" were measured at half yearly age intervals in the "Growth Clinic" of the Institute from August 1994 to November 2018. A total of 2089 observations were made on these children using standardized anthropometric techniques and instruments following a prospective mixed-longitudinal growth research design. Using the LMS method, age and sex-specific percentile growth charts (<1 month to 10 years) for weight, and length/ height were generated. Unpaired t-test was used to compare mean growth attainments of study children with those of DS patients representing other population groups as well as their normal Multicentre Growth Reference Study (MGRS and Indian Academy of Pediatrics (IAP) counterparts. The 50th percentile growth curves for both weight and length/height of Indian children with DS demonstrated a regular increase. As compared to their normal MGRS and Indian (IAP) counterparts, the children with DS had lower weight and height attainments. The boys and girls with Down syndrome showed short stature (height < 3rd centile) from the age of 1 year till 10 years and also became underweight beyond 5 years. As compared to their normal counterparts, children with Down syndrome exhibited compromised auxological attainments. The use of growth charts presented herein may be used to compare and monitor growth and nutritional status of Indian children with Down syndrome.
A patch material comprising a layer structure having a base material layer provided on its one major surface with an adhesive layer.  The base material layer is an elastomer film of 1 to 10 μm thickness.  The adhesive layer has a thickness of 1 to 15 μm.  The total thickness of the base material layer and adhesive layer is in the range of 2 to 20 μm.  The 10% tensile loads of the patch material in the length and breadth directions are simultaneously in the range of 0.01 to 1.2 N/10mm.  When the 10% tensile load of the patch material in the length direction is referred to as X (N/10mm), the value of thickness of the patch material as Y (μm) and the value of thickness of the base material layer as Z (μm), the patch material satisfies the relationship XY=0.02 to 15, or XZ=0.01 to 7.  The adhesive layer exhibits an adhesive strength of 0.1 N/10mm or greater.
### Prevention of Initial Attacks of Rheumatic Fever

Penicillin is considered by the American Heart Association to be the drug of choice in the prevention of initial attacks of rheumatic fever (treatment of Streptococcus pyogenes infections of the upper respiratory tract e.g., tonsillitis, or pharyngitis). Erythromycin is indicated for the treatment of penicillin-allergic patients. The therapeutic dose should be administered for ten days. 4

### Prevention of Recurrent Attacks of Rheumatic Fever

Penicillin or sulfonamides are considered by the American Heart Association to be the drugs of choice in the prevention of recurrent attacks of rheumatic fever. In patients who are allergic to penicillin and sulfonamides, oral erythromycin is recommended by the American Heart Association in the long-term prophylaxis of streptococcal pharyngitis (for the prevention of recurrent attacks of rheumatic fever). 4