anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study examines a social media based peer-led and delivered intervention focused on increasing PrEP adoption in young men of color who have sex with men (YMCSM). While prior efficacy trials have included YMCSM 18-29, we will focus on PrEP in YMCSM outside clinical trial settings. Rather than an alternative medium for implementation of existing interventions designed for in-person contact, social media may be a true 'game changer' to engage hard to reach individuals. While many online behavioral interventions exist, including some that use social media, this will be one of the few studies to use and test social media to facilitate uptake of a biomedical intervention. E-PrEP will connect the target population (YMCSM) to a new prevention tool (PrEP) through rapid linkage to medical care, accelerating diffusion of PrEP. Given the paucity of data regarding social media-based interventions to change health-related behavior, E-PrEP may have a marked impact on future bio-behavioral interventions, especially those that include diffusion of innovation. Social media offers the power of scale and efficiency for large potential impact, even with relatively low-intensity interventions. Similarly, PrEP, if widely adopted in high-risk populations and offered with behavioral interventions, could markedly decrease HIV infection rates. Social media-based, peer-led approaches like E-PrEP could be used to enhance efforts by community-based and other organizations that employ internet-assisted or peer-outreach strategies to improve health.

Primary Aim: To test the feasibility and preliminary efficacy of E-PrEP for increasing PrEP adoption in a cluster-randomized controlled trial.
A planned ventral hernia after open abdomen therapy is a rare hernia entity because the fascial closure rate has been increased due to established concepts for open abdominal treatment. Nevertheless, fascial closure is not always successful, and a planned ventral hernia has to be treated later. Preoperative optimisation and planning are essential for such challenging abdominal wall repairs.In a single centre retrospective analysis, all incisional hernias from 2013 to 2023 (n = 632) were identified and planned hernias after a laparostomy were selected (n = 11). The data on surgical management were obtained from the patient files for the operation reports. Literature search was conducted with PubMed (Medline).In all cases a physical examination, abdominal sonography, CT abdomen and a colonoscopy were carried out preoperatively. The median size of the abdominal wall defects were horizontally 13 cm (6-35 cm) and vertically 18 cm (10-28 cm). Botulinum toxin A has been used preoperatively since 2018. Median fascial closure was successful intraoperatively in all 11 patients. The surgical techniques included sublay, IPOM, sandwich technique, intraoperative fascial traction, and component separation.Planned ventral hernias after open abdomen treatment should always be considered complex hernias for which the entire expertise in hernia surgery is required. Comprehensive preoperative optimisation with botulinum toxin A infiltration is essential to facilitate anatomically appropriate reconstruction through midline closure with mesh augmentation.
The invention provides an oxidation resistant polyose extracted from fomitiporia punctata (P.Karst.) Murrill and a preparation method for the oxidation resistant polyose. The oxidation resistant polyose is prepared through the following steps: after fomitiporia punctata (P.Karst.) Murrill fruiting bodies are smashed into powder, hot water extraction, ethanol precipitation, deproteinization, dialysis, lyophilization and ion-exchange are conducted. A molecular sieve is adopted. The oxidation resistant polyose is straw yellow powder, and 151 KDa in molecular weight, comprises four monosaccharides namely arabinose, laevulose, galactose and glucose with the ratio of 1:6:29:43, has two configurations, namely alpha and beta, is dissolved in water easily, and not soluble in organic solvents such as ethanol, diethyl ether and acetone. The polyose has a relatively high rat erythrocyte hemolysis resistance, and certain effects of cleaning DPPH, superoxide anion and hydroxyl radical; the fomitiporia punctata (P. Karst.) Murrill oxidation resistant polyose provided by the invention is a natural extractive; meanwhile, the preparation method is simple, the cost is relatively lower, and the purity is high.
ACE-Seniors is designed as a single-site trial of four randomly assigned interventions, Tai Chi exercise, autobiographical writing, both Tai Chi and autobiography (dual intervention), and general health education. Participants are relatively healthy adults aged 70 years or older, who are not regular practitioners of Tai Chi or regular writers. They are without medical or neurological disorders that would substantially limit the ability to participate in study interventions, without dementia or mild cognitive impairment, relatively sedentary, able to walk unassisted, and able to score 4 or better on the Short Physical Performance Battery. Interventions are administered over a 6 month period of time, with similar exposure times among the four groups. The prespecified primary endpoint is derived from a composite neuropsychological measure, based on three tests of executive function and three tests of episodic memory. The planned sample size is 96 (24 per group). Intention-to-treat analysis will include all eligible participants who complete baseline assessments.
PURPOSE: Intraoperative acetabular fracture (IAF) is a non-common complication of primary total hip arthroplasty (THA). Despite the prevalence of intraoperative periprosthetic fractures are increasing, little has been written about this type of fracture. The main objective is to analyze possible risk factors, treatment options and functional outcomes associated with IAF.
METHODS: Between 2006 and 2020, 4 senior arthroplasty surgeons performed 5540 uncemented primary THA. We reviewed our Total Joint Registry and found 18 cases with an IAF. We analyzed demographic factors, medical history, preoperative diagnose, acetabular cups designs, anatomic location of the fracture, treatment, associated complications and functional outcomes. The minimum duration of follow-up was 12 months.
RESULTS: The prevalence of an IAF was 0,3%. All the acetabular cups were hemispherical modular. The most frequent acetabular cup associated with an IAF was the CSF Plus (JRI). In two cases the acetabular components were judged to be stable and no additional treatment was done. In the other sixteen patients, various surgical procedures were carried out. Almost 30% of patients that sustained an IAF had some complication during their follow up. Moreover, poor functionality outcomes were obtained (12.1 ± 4.1). in the final follow up accordance to Postel Merle d'Aubingé score.
CONCLUSION: Although IAF is a rare complication of THA, maintaining a high index of suspicion is important as they can be difficult to identify. Still with an adequate early treatment they have poor functionality and high risk of associated complications.
PURPOSE: To maintain a sculptural object permanently in a durable and aesthetic way by coating an external surface and, if necessary, an inner surface of a sculptural object with a thin radiation-setting color layer and then setting the external surface with a properly thin and almost colorless or translucent layer. CONSTITUTION: An especially desiable manner of sealing up the sculptural object is to use setting compounds filled up to about 50% with methacryloylsilanized silica gel sintered at a high temperature. These compounds possess thin consistency, are easy to apply, and show high hardness. In addition, they are highly abrasion resistant and can be scraped to give a high gloss. A sealing up layer is applied to an external layer of a sculptural part whose color properties have been determined up to 0.5mm in thickness, and, after being set, a surface treatment is given. That is to say, the last layer of a sealed-up compound to be applied is given the final coat with a special dry- setting and radiation-setting coating. When it is applied as a thin layer from 0.01 to 0.02mm in thickness, its oxygen protection is achieved and the layer beneath it is optimally and completely polymerized.
PURPOSE: To efficiently obtain the subject compd. useful as an antibacterial agent by subjecting a novel intermediate to hydrogenation treatment in a ketone solvent to acylate the hydrogenated intermediate, and applying a specified treatment to the formed compd. to couple the treated compd. with a specified compd.  
     CONSTITUTION: At first, a salt compd. represented by formula I (wherein Z is benzoleoxycarbonyl, X is H or alkaline earth metal A 1  is -HN- or a group represented by formula II, and R 2  and R 3  are H or alkyl) is treated with hydrogen in a ketone solvent represented by formula III (wherein R and R' are alkyl or combined with a C-atom of them to form 5-7-membered cycloalkyl) in the presence of a catalyst, and the hydrogenated compd. is subsequently acylated to obtain a compd. represented by formula IV (wherein R 1  is acyl derived from carboxylic acid). Subsequently, an alkylidene group is eliminated from the compd. represented by the formula IV and the resulting compd. and a compd. represented by formula V (wherein Prot is a protective group) are subjected to coupling reaction and, further, the protective group is eliminated from the formed compd. to obtain the objective compd. represented by formula VI. The compd. represented by the formula II is a novel substance. 
     COPYRIGHT: (C)1990,JPO
PURPOSE:To provide the subject substance composed of an avian egg white- derived sialoglicoprotein capable of directly acting on an animal or human tumor cell, exhibiting a cell membrane-modifying activity and an inhibitory effect on the growth function of a tumor cell and useful as an antitumor agent. CONSTITUTION:An unfertilized egg immediately after egg production of a white leghorn chicken is used and its egg white is collected, sieved and subsequently centrifuged. The resultant gel-state part is washed with a 2wt.% KCl solution, then suspended in a buffer solution and solubilized by ultrasonic treatment so as to obtain a solubilized ovomucin. The obtained solubilized ovomucin is subjected to anion-exchange column chromatography treatment to give beta- ovomucin. The resultant fraction is dialyzed by using deionized water and, after substitution with a 10mM tris-hydrochloric acid buffer solution (pH7.2), subjected to WGA-agarose column treatment. The adsorbate is eluted by using a 0.1wt.% sodium azide and desalted by ultrafiltration. Thereby, there is obtained the objective antitumor substance composed of an avian egg white- derived sialoglicoprotein, capable of directly acting on an animal or human tumor cell and exhibiting a cell membrane-modifying activity.
OBJECTIVE: To evaluate the clinical efficacy and imaging outcomes of percutaneous endoscopic lumbar discectomy (PELD) combined with platelet-rich plasma (PRP) for the treatment of lumbar disc herniation (LDH).
METHODS: A total of 155 patients with LDH between January 2020 and June 2022 were retrospective analyzed, of which 75 underwent PELD with PRP and 80 underwent PELD only. Clinical functional scores and imaging data were compared. Clinical functional scores included visual analog scale of leg pain (VAS-LP) and back pain (VAS-BP), Japanese Orthopedic Association score (JOA), Oswestry Disability Index (ODI) and modified MacNab criteria. Imaging data included disc height index (DHI), spinal cross-sectional area (SCSA), disc protrusion size (DPZ), and ratio value of disc grey scales (RVG).
RESULTS: Both groups showed clinical improvement, and VAS-LP, VAS-BP, JOA and ODI were significantly improved in the PRP group compared with the control group at 3, 6 and 12 months postoperatively (P < 0.05). At the last follow-up, the differences in SCSA, DPZ and RVG between the two groups were statistically significant (P < 0.05), with the PRP group being superior to the control group. The excellent and good rates of the modified Macnab criteria in the PRP group and control group were 93.3% and 90%, respectively, with no statistically significant difference (P > 0.05). No serious complications occurred during the follow-up period.
CONCLUSION: PELD combined with PRP is a safe and effective method for treating patients with LDH. PRP injection was beneficial for delaying disc degeneration and promoting disc remodeling.
The invention discloses a traditional Chinese medicine combination for treating neonatal jaundice. The combination comprises oriental wormwood and bamboo charcoal. Under the catalytic action of the bamboo charcoal, the oriental wormwood which has a treating effect quickly achieves the effect of bilirubin lowering. The combination has obvious effects on treating of neonatal jaundice, especially pathologic jaundice; the number of side effects is small; stability is good. Meanwhile, the combination also has the treating effect on physiologic jaundice. Using is safe; untoward effects and toxic and side effects are avoided. When the combination is used and skin jaundice fades away, serum bilirubin reaches the normal range; the illness state of a sick child is effectively controlled; after neonatal jaundice fading away, the recurrence rate is very low, and the curative effect is positive. The overall response rate reaches at least 83.3%. Using is convenient and safe. Medicine sources are wide. Preparation machining is easy. Price is economical. Clinical application is safe and effective. Stability is good. A patient can accept the combination easily. Promoting is easy.
A patient's image data and associated metadata describing the image data and characteristics of the patient are received and stored in a memory area. Information that describes one or more imaging analysis services and associated service criteria is accessed and compared to the metadata. Based on matches between the image metadata and service criteria, services are selected and executed, producing an output. Iterative rounds of service matching based on the metadata and the output of previous services and service execution proceed. The output of the services is associated with the image data and metadata, stored in the memory area, and made available to the user. A data repository, including the original images, metadata, and service output is accessible via the services for use in comparative analyses. Such services can utilize the repository to dynamically update indices and algorithms used in the comparative analyses.
Reproduction studies have been performed in rats and mice at exposures up to 17 times the MRHD of 40 mg and have revealed no evidence of impaired fertility or harm to the fetus because of tadalafil. In addition, there was no evidence of teratogenicity, embryotoxicity, or fetotoxicity when tadalafil was given to pregnant rats or mice at exposures up to 7 times the MRHD during the period of major organ development.

In a rat prenatal and postnatal development study at doses of 60, 200, and 1000 mg/kg, a reduction in postnatal survival of pups was observed. The no-observed-effect-level (NOEL) for maternal toxicity was 200 mg/kg/day and for developmental toxicity was 30 mg/kg/day. This gives approximately 8- and 5-fold exposure multiples, respectively, of the human AUC for the MRHD of 40 mg. Tadalafil and/or its metabolites cross the placenta, resulting in fetal exposure in rats.

Tadalafil and/or its metabolites were secreted into the milk in lactating rats at concentrations approximately 2.4–fold greater than found in the plasma.
PURPOSE: Pathophysiological hallmarks of Alzheimer's disease (AD) include extracellular amyloid plaques and intracellular neurofibrillary tangles. Recent studies also demonstrated a role of neuroinflammation in the progression of the disease. Clinical trials and animal studies using low-dose radiation therapy (LDRT) have shown therapeutic potential for AD. This systematic review summarizes the current evidence on the use of LDRT for the treatment of AD, outlines potential mechanisms of action, and discusses current challenges in the planning of future trials.
METHODS AND MATERIALS: A systematic review of human and animal studies as well as registered clinical trials describing outcomes for RT in the treatment of AD was conducted. We followed the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles published until July 1, 2023, were included.
RESULTS: The initial search yielded 993 articles. After the removal of duplicates and ineligible publications, a total of 16 (12 animal, 4 human) studies were included. Various dose regimens were utilized in both animal and human trials. The results revealed that LDRT reduced the number of amyloid plaques and neurofibrillary tangles, and it has a role in the regulation of genes and protein expression involved in the pathological progression of AD. LDRT has demonstrated reduced astro- and microgliosis, anti-inflammatory and neuroprotective effects, and an alleviation of symptoms of cognitive deficits in animal models. Most studies in humans suggested improvements in cognition and behavior. None of the trials or studies described significant (>grade 2) toxicity.
CONCLUSIONS: Preclinical studies, animal studies, and early clinical trials in humans have shown a promising role for LDRT in the treatment of AD pathologies, although the underlying mechanisms are yet to be fully explored. Phase I/II/III trials are needed to assess the long-term safety, efficacy, and optimal treatment parameters of LDRT in AD treatment.
The exposure of interest is Dayingpian. Patients in this group take Dayingpian as monotherapy for bipolar disorder. The psychiatrist does not assign specific interventions to the study participants. The course of observation is 12 weeks.
The aim of the study is to investigate proprioceptive exercises training combined with aerobic exercises and resistive exercises training combined with aerobic exercises on dynamic balance and superficial sense. The study included 30 volunteers with Type 2 Diabetes Mellitus(T2DM) who were referred to Fitness Center Arif Nihat Asya Kültür Merkezi Istanbul, Turkey by a medical doctor between December 2016- March 2017 and got diagnosed and followed up at least 6 month before. Glycemic control of all the participants were assessed according to fasting blood glucose and glycolated hemoglobin (HbA1c). Waist and hip circumference was recorded in centimeters. Six minute walking test (6MWT) was used to determine functional capacity of participants. We evaluated the dynamic balance of patients by Prokin PK200, Italy. Five parameters were obtained from Prokin as; Perimeter Length (PL), Area gap percentade (AGP) Medium Speed (MS), Anteroposterior equilibrium (AP) and Mediolateral equilibrium (ML). Proprioception assessment was done with angle reproduction test in direction of dorsiflexion and plantar flexion and deviations were recorded. Superficial sense was assessed with two point discrimination test and vibration threshold was evaluated by biothesiometer. Lower extremity muscles strength were assessed with handheld dynamometer (PowerTrack II commander, JTech Medical, Midvale, UT). The patients were randomly divided into Proprioceptive Exercise Training Group (PG) and Resistive Exercise Training Group (RG). All subjects were included exercise education program and both groups had trained aerobic exercise program for walking on treadmill (2times/wk. 6 week duration). The proprioceptive exercise program was applied in PG and the resistive exercise program was applied in RG twice a week and for duration 6 week.
Patients with Alzheimer's disease were able to return to their normal lives when dapsone stopped the inflammation and protected the brain cells. These findings suggest that the cause of dementia syndrome, including Alzheimer's disease, is probably due to an inflammatory response. The NPI-Q and K-IADL items in the test for the presence of cognitive impairment can be checked by examining whether the patient has returned to his/her daily life. Inflammatory reactions are intensified by various causes in brain cells, and these cells are attacked by hypochlorite. Various foreign substances and intracellular components accumulate and cause brain cells to die. Here, dapsone was used as a prophylactic material for stopping neuronal death. From this invention, we will be able to prevent the development of a broad spectrum of dementia syndrome  18 .
Participants allocated to the yoga group will receive the yoga-based intervention through an internet-based video conference remotely in real-time. Each class will accommodate a maximum of 5 subjects. A qualified physiotherapist who was a certificated yoga instructor will teach in these classrooms. The 8-week exercise intervention consists of three times per week sessions of yoga.
The invention relates to hepatitis A viruses (HAVs) having a serotype displaying the immunological characteristics of the HAV strain RG-SB XA112 (CNCM I-1080). In particular, the invention relates to the new hepatitis A virus strain RG-SB XA112 (CNCM I-1080). The invention also relates to structural components of said HAVs. Furthermore, the invention relates to processes for the isolation of said HAVs. The HAVs of the present invention and the structural components thereof can be used for the production of vaccines and diagnostic compositions. Finally, the invention relates to polyclonal and monoclonal antibodies which are directed to said new HAVs.
Patients receiving Cannabidiol oil drops, administered sublingual, 3 times a day, while hospitalized. Dosing and administration frequency would be assessed bi-daily by the medical staff.
Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.
Patients will receive 300 mg of aspirin before PCI unless they have previously received this antiplatelet medication. A loading dose of clopidogrel 600 mg will be given before or after PCI as soon as possible following randomization, unless they have previously received the assigned medication. Aspirin 100 mg plus clopidogrel 75 mg once daily will be given for one year.
This definite and absolute cure against HIV and AIDS is based on facts that, in several biting and bloodsucking insects, HIV can neither reproduce nor survive. Therefore these insects never transmit HIV or AIDS from an infected host to the humans they next feed on or bite. Irrespective of the quantity of HIV in the bloodstreams of an infected host, and of whether insect mouthparts do or do not retain large amounts of blood on their surfaces, these antibodies or similar substances in the saliva or salivary glands of these insects will always render HIV inactive thereby making HIV unable to reproduce or survive, i.e. these substances will always destroy HIV outright. These substances are extracted and tested on HIV and AIDS. Following a successful result, extracted and / or artificially synthesized forms of the substances are used in preparing vaccines against HIV and medicines against AIDS.
Experimental Intervention: The CS shall be carried out in groups (5-7 participants), twice a week. Each session lasts 90 minutes. CS sessions begin with a training for temporal and spatial orientation in which participants are asked to recognize and recall the date and the place with the help of some environmental aids (calendars, clocks, pictures and maps). Then the participants complete an array of cognitive tasks for memory, attention, language, visuo-spatial functions and executive functions. These tasks range from individual paper-and-pencil exercises to verbal-learning exercises that have to be solved by the group.