anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A unique medication distribution system for compliance packaging of medications, designed to contain each individual's unique daily medications and supplements and enhance the timely administration of the medications. The production and distribution of the system is automated and highly integrated with the database software as well as business software managed and operated by a pharmacy. The system comprises of a card made up of plastic, paper or composite materials with blister components containing the medication. The card can be bipartite or multipartite according to the medication needs of a user, with foldable side panels. An array of the timing corresponding to each medication is printed on the card. Corresponding to each medication is also an array listing the name of the doctor, the name of the medication and the rationale for its administration. A side panel may have sleeves or pockets containing salves, ointments, patches, lotions or milks, when prescribed to the user. A side panel may be customized to advertising targeting the market defined by individuals who take several medications in a day.
Participants will view short video narratives of community members speaking about why they chose to get vaccinated against Coronavirus Disease of 2019 (COVID-19) and how they overcame hesitancy. Participants will also view the informational videos described below.
622,530. Glass manufacture. CORNING GLASS WORKS. March 19, 1947, No. 7601. Convention date, March 28, 1946. [Class 56] A substantially pure silica article comprising a skeleton with intercommunicating sub-microscopic pores (formed by melting and shaping glass of a lower silica content and extracting the soluble constituents therefrom by lixiviation, e.g., as in Specification 442,526), is consolidated by heating to a temperature below its melting point while maintaining a partial pressure of oxygen in its pores at substantially zero. Tubes for medium pressure mercury arc lamps made in this way do not evolve gas internally in use, are transparent to u.v. light down to 2,540A (due to reduction of any residual Fe 2 O 3  to FeO), and if a vacuum is used as the means for eliminating the oxygen, are free from any arsenic (used as a fining agent) which might otherwise remain. An electric resistor type vacuum furnace may be used in which the article is heated slowly to 600-900‹C. in a reducing atmosphere, e.g. of 92 per cent N and 8 per cent H, held at about 1,000‹ in vacuo for half an hour, and then heated still in vacuo, to 1,225‹ to complete consolidation to a non-porous state.
NEW MATERIAL:An antibiotic KA-6643-B shown by the formula and its salt. USE:An antibiotic effective against Gram-positive and Gramnegative bacterial, and effective against bacteria having resistance to various kinds of beta-lactam antibiotics. PROCESS:A streptomyces sp KC-6643(FERM-P 4467) is cultured aerobically at 3-35 deg.C, preferably at 27-33 deg.C by liquid cultivation, especially deep part cultivation, and the culture solution is subjected to centrifugation or filtration to remove the mold. The culture filtrate is made to flow through a basic anion exchange resin, and substance KA-6643 is adsorbed. The substance KA-6643 is eluted with s salt solution or an aqueous methanol solution of salt. The solution is made to flow a strongly basic ion exchange resin, and the substance FA-6643 is eluted by changing a salt concentration in a buffer solution of phosphoric acid stepwise. The substance KA-6643-A is eluted at early stage, and the substance KA-6643-B shown by the formula is then eluted. Both substance are separated.
The ABSORB Everolimus-eluting Bioresorbable Vascular Scaffold (BVS 1.1, Abbott Vascular, California, USA, CE approved) is Device marked CE, currently the most studied PLA (Polylactic acid) based scaffold. It consists of PLLA (Poly I-lactic acid) backbone with 1:1 PDLLA (Poly-DL Lactic Acid) drug surface coating and a total strut thickness of 156 μm.
FIELD: cosmetology. ^ SUBSTANCE: invention refers to cosmetic industry, particularly to skin whitening composition. Cosmetic method of skin whitening involves covering the skin with the composition containing a certain amount of extract Nigrospora sphaerica and cosmetically acceptable carrier. The cosmetic composition includes a certain amount of extract Nigrospora sphaerica, cosmetically acceptable carrier and an agent good for skin, and/or a sunscreen agent where the agent good for skin is chosen from the group consisting of alpha-hydroxy acids, beta- hydroxy acids, polyhydroxy acids, hydroquinone, tert-butylhydroquinone, vitamin B and/or C derivatives, dicarboxylic acids, retinoids, resorcin derivatives, vanillic acid, betulinic acid, hydrolactine and their mixtures. ^ EFFECT: method and composition described above effectively whiten the skin. ^ 17 cl, 8 tbl, 12 ex
This study aims to monitor and predict biofeedback therapy based on mechanism-based and highly integrated data using a new medical device. This study is specifically for patients with dyssynergia before, during, and after biofeedback therapy. The balloon-like Fecobionics device (10 cm long and 1 cm in diameter) will be inserted into the participant's rectum and will record data before and during the expulsion of the device. The participant will be asked to do different motions like cough, squeeze, or push during the procedure. The novel data obtained in this study may help the investigators to identify the patients who will benefit or not benefit from biofeedback therapy before the therapy is done. This will determine the effectiveness of treatments for anorectal disorders.
BACKGROUND: We aim to use Natural Language Processing to automate the extraction and classification of thyroid cancer risk factors from pathology reports.
METHODS: We analyzed 1410 surgical pathology reports from adult papillary thyroid cancer patients from 2010 to 2019. Structured and nonstructured reports were used to create a consensus-based ground truth dictionary and categorized them into modified recurrence risk levels. Nonstructured reports were narrative, while structured reports followed standardized formats. We developed ThyroPath, a rule-based Natural Language Processing pipeline, to extract and classify thyroid cancer features into risk categories. Training involved 225 reports (150 structured, 75 unstructured), with testing on 170 reports (120 structured, 50 unstructured) for evaluation. The pipeline's performance was assessed using both strict and lenient criteria for accuracy, precision, recall, and F1-score; a metric that combines precision and recall evaluation.
RESULTS: In extraction tasks, ThyroPath achieved overall strict F-1 scores of 93% for structured reports and 90% for unstructured reports, covering 18 thyroid cancer pathology features. In classification tasks, ThyroPath-extracted information demonstrated an overall accuracy of 93% in categorizing reports based on their corresponding guideline-based risk of recurrence: 76.9% for high-risk, 86.8% for intermediate risk, and 100% for both low and very low-risk cases. However, ThyroPath achieved 100% accuracy across all risk categories with human extracted pathology information.
CONCLUSIONS: ThyroPath shows promise in automating the extraction and risk recurrence classification of thyroid pathology reports at large scale. It offers a solution to laborious manual reviews and advancing virtual registries. However, it requires further validation before implementation.
Younger adults (ages 18-30) randomized to this arm will receive 2 sessions of sham tDCS stimulation (Soterix Medical) delivered to either the left dorsolateral prefrontal cortex (area F3 using the 10-20 EEG system, n = 25), or the left parietal cortex (area P5 using the 10-20 EEG system, n = 25). One session will occur in the morning (8 or 9am) and one will occur on a separate day in the afternoon (3 or 4pm).
OBJECTIVE: Black Americans have a greater risk of type 2 diabetes than White Americans. The proinflammatory cytokine interleukin-6 (IL-6) is implicated in diabetes pathogenesis, and IL-6 levels are higher in Black individuals. This study investigated associations of IL-6 with incident diabetes and metabolic syndrome in a biracial cohort.
RESEARCH DESIGN AND METHODS: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study enrolled 30,239 Black and White adults age ≥45 years in 2003-2007, with a follow-up ∼9.5 years later. Baseline plasma IL-6 was measured in 3,399 participants at risk of incident diabetes and 1,871 at risk of metabolic syndrome. Relative risk (RR) by IL-6 was estimated with modified Poisson regression for both groups.
RESULTS: Incident diabetes occurred in 14% and metabolic syndrome in 20%; both rates rose across IL-6 quartiles. There was a three-way interaction of IL-6, race, and central adiposity for incident diabetes (P = 8 × 10-5). In Black participants with and without central adiposity, RRs were 2.02 (95% CI 1.00-4.07) and 1.66 (1.00-2.75) for the fourth compared with first IL-6 quartile, respectively. The corresponding RRs were 1.73 (0.92-3.26) and 2.34 (1.17-4.66) in White participants. The pattern was similar for IL-6 and metabolic syndrome.
CONCLUSIONS: Although IL-6 was higher in Black than in White participants and those with central adiposity, the association of IL-6 with diabetes risk was statistically significant only among White participants without central adiposity. The association with metabolic syndrome risk was similarly stronger in low-risk groups. The results support the concept of interventions to lower inflammation in diabetes prevention, but to reduce race disparities, better biomarkers are needed.
An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in septic cardiomyopathy. By analyzing the mouse myocardial transcriptome from sepsis induced by cecum ligation and puncture (CLP), we identified four distinct k-means clusters. Further analysis of human myocardial datasets using Weighted Gene Co-expression Network Analysis (WGCNA) revealed a strong correlation between the MEturquoise module and septic cardiomyopathy (cor = 0.79, p < .001). Through the application of Cytoscape plug-in MCODE and comprehensive analysis, we pinpointed two signature genes, THBS1 and TIMP1. These genes demonstrated significant involvement in immune cell infiltration, as detected by CIBERSORT, and displayed promising prognostic potential as validated by external datasets. Our experimental validation confirmed the up-regulation of both THBS1 and TIMP1 in septic murine hearts, underscoring their positive association with septic cardiomyopathy.
A system and method for offering medical information for protecting personal information and supplying a medical research is provided to separate the personal information and the medical examination information. A medical information system includes a patient terminal(100), a hospital server(200), and a personal information managing server(300). A personal ID database(140) stores personal information of each patient such as a name, address, telephone number, and so on. A non-ID information database(120) stores information, which is not able to exactly know the person, for a medical research among the personal information of the patients. An insurance information database(130) stores an insurance organization and a number of an insurance policy. A medical examination code generator(240) codes details of the medical examination of the patient. The codes generated in the medical examination code generator(240) are stored in the hospital server(200), the patient terminal(100), and a medical examination code list database(110, 210, 310) of the personal information managing server(300). A medical examination information database(220) stores information of medical treatment performed to the patients in the hospital.
Noncoding RNAs have been shown to play essential roles in hypoxic pulmonary hypertension (HPH). Our preliminary data showed that HPH is attenuated by fibroblast growth factor 21 (FGF21) administration. Therefore, we further investigated the whole transcriptome RNA expression patterns and interactions in a mice HPH model treated with FGF21. By whole-transcriptome sequencing, differentially expressed mRNAs, miRNAs, lncRNAs, and circRNAs were successfully identified in normoxia (Nx) vs. hypoxia (Hx) and Hx vs. hypoxia + FGF21 (Hx + F21). Differentially expressed mRNAs, miRNAs, lncRNAs, and circRNAs regulated by hypoxia and FGF21 were selected through intersection analysis. Based on prediction databases and sequencing data, differentially co-expressed mRNAs, miRNAs, lncRNAs, and circRNAs were further screened, followed by functional enrichment analysis. MAPK signaling pathway and epigenetic modification were enriched and may play fundamental roles in the therapeutic effects of FGF21. The ceRNA regulatory network of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA was constructed with miR-7a-5p, miR-449c-5p, miR-676-3p and miR-674-3p as the core. In addition, quantitative real-time PCR experiments were employed to verify the whole-transcriptome sequencing data. The results of luciferase reporter assays highlighted the relationship between miR-449c-5p and XR_878320.1, miR-449c-5p and Stab2, miR-449c-5p and circ_mtcp1, which suggesting that miR-449c-5p may be a key regulator of FGF21 in the treatment of PH. Taken together, this study provides potential biomarkers, pathways, and ceRNA regulatory networks in HPH treated with FGF21 and will provide an experimental basis for the clinical application of FGF21 in PH.
Concomitant use of benzodiazepines, including alprazolam tablets, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. 

  


Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. If a decision is made to prescribe alprazolam tablets concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose of alprazolam tablets than indicated in the absence of an opioid and titrate based on clinical response. If an opioid is initiated in a patient already taking alprazolam tablets, prescribe a lower initial dose of the opioid and titrate based upon clinical response. 

  


Advise both patients and caregivers about the risks of respiratory depression and sedation when alprazolam is used with opioids. Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined [see Drug Interactions (7.1)].
<P>PROBLEM TO BE SOLVED: To provide a therapeutic or a preventive agent for allergic conjunctivitis or eye pruritus, which consists of a combination of levocabastine or its salt and pemirolast or its salt.  <P>SOLUTION: The first invention is the therapeutic or the preventive agent for allergic conjunctivitis or eye pruritus, which consists of the combination of levocabastine or its salt and pemirolast or its salt. The second invention is the therapeutic or the preventive agent for allergic conjunctivitis or eye pruritus which is characterized in that it consists of the combination of levocabastine or its salt and pemirolast or its salt, and in that both of them are supplementarily acting each other and/or mutually reinforced. According to the invention, through administrating in combination of levocabastine hydrochloride and potassium pemirolast, an anti-pruritus action and an anti-allergic action are reinforced. Thus, the invention is useful for the therapy or the prevention of allergic conjunctivitis or eye pruritus.  <P>COPYRIGHT: (C)2004,JPO
Calcitonin acts primarily on bone, but direct renal effects and actions on the gastrointestinal tract are also recognized. Calcitonin-salmon appears to have actions essentially identical to calcitonins of mammalian origin, but its potency per mg is greater and it has a longer duration of action.

The information below, describing the clinical pharmacology of calcitonin, has been derived from studies with injectable calcitonin. The mean bioavailability of calcitonin-salmon nasal spray is approximately 3% of the injectable calcitonin in normal subjects and, therefore, the conclusions concerning the CLINICAL PHARMACOLOGY of this preparation may be different.

The actions of calcitonin on bone and its role in normal human bone physiology are still not completely elucidated, although calcitonin receptors have been discovered in osteoclasts and osteoblasts.

Single injections of calcitonin cause a marked transient inhibition of the ongoing bone resorptive process. With prolonged use, there is a persistent, smaller decrease in the rate of bone resorption. Histologically, this is associated with a decreased number of osteoclasts and an apparent decrease in their resorptive activity. In vitro studies have shown that calcitonin-salmon causes inhibition of osteoclast function with loss of the ruffled osteoclast border responsible for resorption of bone. This activity resumes following removal of calcitonin-salmon from the test system. There is some evidence from in vitro studies that bone formation may be augmented by calcitonin through increased osteoblastic activity.

Animal studies indicate that endogenous calcitonin, primarily through its action on bone, participates with parathyroid hormone in the homeostatic regulation of blood calcium. Thus, high blood calcium levels cause increased secretion of calcitonin which, in turn, inhibits bone resorption. This reduces the transfer of calcium from bone to blood and tends to return blood calcium towards the normal level. The importance of this process in humans has not been determined. In normal adults, who have a relatively low rate of bone resorption, the administration of exogenous calcitonin results in only a slight decrease in serum calcium in the limits of the normal range. In normal children and in patients with Paget's disease in whom bone resorption is more rapid, decreases in serum calcium are more pronounced in response to calcitonin.

Bone biopsy and radial bone mass studies at baseline and after 26 months of daily injectable calcitonin indicate that calcitonin therapy results in the formation of normal bone.
Endometrial sampling is performed using the standard technique in the outpatient department. Similarly, superovulation with gonadotrophins will be performed according to our standard practice.Endometrial sampling will be done in the follicular phase not later than day 10 of the cycle. Endometrial sampling will be performed using Pipelle sampling catheter. The Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator. Then, the piston is withdrawn to create negative suction and gentle movement of Pipelle up and down in the uterine cavity is performed while it is against the uterine wall. The Pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.
OBJECTIVE: This study aimed to explore the association between occupational psychosocial exposures and chronic low-back pain (LBP) by conducting a systematic review and meta-analysis.
METHODS: The research protocol was registered in PROSPERO. A systematic literature search was performed in six databases, identifying articles complying with predefined inclusion criteria. In our PECOS, we defined outcome as chronic LBP ≥3 months, exposures as occupational psychosocial exposures, and restricted study design to case-control and cohort studies. Two authors independently excluded articles, extracted data, assessed risk of bias, and graded evidence levels. Meta-analyses were performed using random-effects models.
RESULTS: The 20 included articles encompassed six different occupational psychosocial exposures (job control, demand, strain, support, stress, and satisfaction), only 1 had low risk of bias. For all occupational psychosocial exposures, odds ratios ranged from 0.8 to 1.1. Sensitivity analyses based on risk of bias was conducted for two outcomes ie, job control and job demand, finding no differences between high and low-to-moderate risk of bias studies. Using GRADE, we found a very low level of evidence of the association for all occupational psychosocial exposures.
CONCLUSION: In this study, we found no association between occupational psychosocial exposures and chronic LBP. However, it is important to underline that the level of evidence was very low. High quality studies are highly warranted.
BACKGROUND: Magtrace is a supraparamagnetic iron lymphatic tracer that has had increasing use in sentinel node biopsy (SNB) for breast cancer and has theoretical logistical benefits in centres where nanocolloid use may be associated with such issues. We describe our initial experience with the introduction of Magtrace into our routine practice by dual localisation with nanocolloid, comparing performance, and concordance.
MATERIALS AND METHODS: This was prospective study of the first patients undergoing axillary SNB using Magtrace in a single centre. These patients had dual localisation with nanocolloid and Magtrace. Subjective global assessments of Magtrace and nanocolloid performance as well as objective signal strength and anatomical concordance were compared across multiple timepoints in the operative journey.
RESULTS: A total of 30 consecutive patients underwent SNB within the timeframe of this study. While there were no failed SNB, 8 issues were reported including 4 issues of perceived imperfect localisation on global assessment. No patient had a failed or abandoned SNB, and only 1 case had a potential challenge in subsequent management after histopathological examination of the retrieved nodes. The majority of these issues occurred in the first half of the study period. There was overall weak to moderate positive correlation between Magtrace and nanocolloid signals of the retrieved sentinel nodes (Spearman's ρ = 0.392, P = .043).
CONCLUSION: This study suggests that introducing Magtrace was feasible and safe in the context of a rural breast cancer service. A possible strategy to ameliorate the learning curve associated with these procedures is the routine dual localisation in the initial phases of performing Magtrace localisation.
We developed an evidence-based bundle of care to address current gaps in care. The bundle: 1) brings together multiple evidence-based assessment tools (ASQ, HEADS-ED) to ensure efficient, high-value ED-based care; 2) removes barriers to assessment and builds connections to care: Assessments are conducted by a mental health care provider and families have access to urgent follow-up care; and 3) prioritizes family engagement: A shared decision-making framework (Choice and Partnership) is used to promote children and youth as stewards of their care and support partnership between EDs and follow-up services with the duration of care determined collaboratively by the patient and their provider.
PROBLEM TO BE SOLVED: To produce a new antibiotic substance capable of effectively controlling the aflatoxin contamination, and provide medicinal uses thereof, and a method for producing the antibiotic substance. SOLUTION: This antibiotic substance aflastatin A is represented by the formula or its salt. The aflatoxin contamination preventing agent, antimicrobial agent, antifungal agent and antitumor agent comprise the antibiotic substance aflastatin A utilized as an active ingredient. The antibiotic substance aflastatin A or its salt is obtained by culturing a microorganism, belonging to the genus Streptomyces and capable of producing the aflastatin A, e.g. a Streptomyces sp. MRI 142 strain (FERM P-15376) and collecting the antibiotic substance aflastatin A from the resultant cultured solution.