anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing or treating colitis. The traditional Chinese medicine composition is suitable for treating the colitis, is particularly suitable for spleen-kidney deficiency cold type chronic colitis, and can effectively solve the problem that chronic colitis is difficult to cure due to chronic diarrhea. The medicines are combined to play the roles of invigorating spleen and warming, eliminating dampness and stopping diarrhea. The prescription is strict, the compatibility is precise and appropriate, and the medicinal threads are screwed according to the characteristics of pathogenesis. Has the advantages of treating both principal and secondary aspect of disease, obvious curative effect, small side effect, convenient administration, low price and the like. The production process is advanced and is beneficial to industrial production.
(see formula I) The present invention provided a PIM kinase inhibitor - a compound with a general structural formula represented by Formula I. Also provided are isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts represented by Formula 1. E, J, Q, X, Y, Z and m in Formula I are defined in Claim 1. A PIM biochemical assay shows that the compounds (1-96) of the present invention can significant inhibit PIM-1 kinase activity. At 3 micromolar concentration, the compounds of the present invention can inhibit PIM-2 and PIM-3 activities by as much as 100%.  Therefore, the PIM kinase inhibitors of the present invention can be used to prepare drugs to treat PIM kinase mediated diseases such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection, thus have great clinical value. Also provided are preparation methods for the compounds represented by Formula I.
For the first 2 weeks of the study participants received 5 mg ramipril orally once a day and were then forced titrated to ramipril 10 mg once a day for 52 weeks. Participants also received placebo to aliskiren for the duration of the study.
It was determined that schizophrenia was seen in 19.78 million people in 2017 and constituted 0.51% of "disability adjusted life years" due to all causes. It has been determined that patients with schizophrenia have care needs in many areas related to daily care such as self-care, relationships and coping even in the early period after discharge. This situation shows that they need support to continue their daily life independently. In this context, families are the closest accessible support elements to the patients. Living with schizophrenia is a difficult situation to deal with for the family as well as for the patient. Caregivers in schizophrenia are dealing with an uncertain future accompanied by hope, fear, or both during the illness process.

Theorist Merle H. Mishel's Uncertainty in Illness Theory (UIT) emerged within the framework of the concept of "uncertainty in illness". The Reconceptualized Uncertainty in Illness Theory (RUIT) was developed to explain chronic conditions that cause individuals to experience uncertainty. "Uncertainty in illness" arises when disease-related processes have characteristics such as complexity, inconsistency, unpredictability, and lack of knowledge. RUIT provides a framework for nurses to develop interventions to improve psychological and behavioral outcomes that occur under uncertainty.Interventions for managing uncertainty help individuals gain knowledge, solve problems, see their health conditions manageable, and improve communication and coping skills. When RUIT based interventions are applied to cancer patients, many positive results have been reported in psychosocial aspects, especially in managing uncertainty.

This study that randomized controlled single blinded experimental nature, was conducted between April 2019 and August 2020 at psychiatry clinic with hospitalized schizophrenia patients caregivers, total of 54 including 27 interventions and 27 control groups. The data were collected by "Caregiver Information Form, Visual Analogue Scale, Intolerance to Uncertainty Scale, Psychological Well-being Scale, Stress Coping Styles Scale". The Uncertainty Management Psychoeducation Program, consisting of a total of five sessions was applied to the intervention group. No intervention was applied to the caregivers in the control group. The psychoeducational intervention, which was individually designed consisting of one session per day for each caregiver and five sessions with a gap of at least two days between sessions, was completed within two weeks. Pre-test and post-test measurements were also carried out during this period, and scales were applied for the pre-test at the beginning of the first session and for the post-test at the end of the last session. Mann-Whitney U and Wilcoxon tests were used for hypotheses.
Postoperative pain is often severe following total knee arthroplasty. Spinal anesthesia is a common method in total knee arthroplasty. Adding morphine to the local anesthetic injected intrathecally prolongs the analgetic effect, but may give the usual opioid side effects. The Local Infiltration Analgesia (LIA) technique has proven effective in reducing postoperative pain in total knee arthroplasty. In the LIA technique a long-acting local anesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac), and epinephrine are infiltrated intraoperatively and via an intraarticular catheter postoperatively.

The aim of this study is to evaluate if spinal anesthesia together with the LIA technique provide better postoperative pain relief and mobilization than spinal anesthesia with addition of morphine to the local anesthetic intrathecally. Primary end-point is morphine consumption the first 48 postoperative hours. Secondary end-points are pain intensity, knee function, time to home readiness, hospital stay, side effects and patient satisfaction. Patients are followed up to 3 months after surgery.
694,469. Furniture frames. KNOLL ASSOCIATES, Inc. July 11, 1951, No. 16404/51. Class 52(ii) A chair &c. construction comprises a seat connected with a shell-like . body having an aperture in its centre portion and shaped so as to include a back rest and means or parts adapted to underlie the seat, at least part of the body surface adjacent to the aperture presenting unidimensional curves which are traceable by a straight line generatrix perpendicular t'o the edge of the aperture. Fig. 1 shows a chair with a shell-like body 32 with parts 40, 42 underlying the seat 20 which is mounted on a support 22. The body may be formed from two blanks 32a, 32b, Fig. 3, of bendable material such as metal, plywood or plastic which after being bent to the forms shown in Fig. 1, are connected at 46 and if desired at 48, the curves bordering the central aperture 44 being generated by straight lines G. Arm rests are formed by the parts 36 and the seat 20 projects rearwardly through the central aperture 44. Fig. 5 shows another construction in which the shell-like body 132 is formed from a single blank or may be moulded. Arm rests are omitted in this form. Upholstery in the form of foam rubber pads secured to the surfaces and covered by slip-on material may be provided.
Frailty is a disorder of several inter-related physiological systems, including genetic and environmental factors in combination with epigenetic mechanisms, which regulate the differential expression of genes in cells and could be especially important in ageing. Frailty syndrome characterized by a progressive decline in health and clinical symptoms of exhaustion, weight loss, a feeling of slowing down, and a decrease in functional capacity. Current interventions focus on interdisciplinary approaches which include nutritional supplementation, physical exercise, and cognitive intervention. The lack of standardized treatment of the disease resulted in the increasing number of elders diagnosed with frailty. Therefore, development of new therapeutic modalities to improve the clinical outcomes and prognosis of frailty syndrome in adult patients is of urgent need. Recently, preclinical and clinical studies support a cell-based, regenerative treatment strategy i.e., allogenic umbilical cord mesenchymal stem cell therapy may represent a novel therapy for aging frailty. This clinical trial is a phase I/II study. Phase I is an open-label study and all eligible subjects will receive a single-dose IV infusion of UMC119-06-05. Phase II study is a randomized, placebo-controlled, single-blind study and half of eligible subjects will receive a single-dose IV infusion of UMC119-06-05, the others will receive placebo.
The research title is the effect of hot footbath on the sleep quality of patients with chronic schizophrenia. The research was a randomized controlled trial. The setting was the chronic inpatient wards at a psychiatric teaching hospital in Northern Taiwan. A total of 63 participants, 30 in the hot footbath group and 33 in the control group, were completed the study from November 2019 to June 2020. Participants were randomly allocated to the experimental group and the control group. The experimental group was given a hot footbath with a temperature of 41℃±1℃ for 20 minutes at about 1-2 hours before sleep, and this was repeated five times a week for four weeks; the control group was given routine care for four weeks. The CPSQI was used to collect the pre- and post-test data. Through this method, we explored whether the trial could effectively improve patients' sleep quality.
The invention relates to a transdermal delivery system comprising at least two components. For example, a thin layer made of a soft solid material and a vehicle solution comprising solvents and other components. A drug that is unstable in solvent but requires solvent for delivery to the skin may be impregnated into the sheet. Other components, such as fixatives for fixing drugs to the sheet, may also be impregnated into the sheet. The two components are stored separately and joined to each other before or at the time of application. In use of the system, the vehicle solution may be applied to the target skin and the sheet, and the sheet is then placed over the target skin such that the vehicle solution is between the sheet and the skin and in contact with the ingredients in the sheet. After the sheet and vehicle solution are combined by this method, the components contained in the sheet and solvent combine to form a formulation that delivers the drug to the skin at a desired rate. The thin layer may have sufficiently low solvent and water vapor permeability to control the time for the solvent to evaporate from the thin layer. When a suitable local anesthetic, such as tetracaine, is a drug, some embodiments of the system of the present invention may have a very broad application in anesthesia and analgesia.
PURPOSE: Toothpaste of a sheet type is provided to ensure portability and to prevent dental disorders. CONSTITUTION: Toothpaste of a sheet type is prepared by making toothpaste(100) in a sheet form. The toothpaste of sheet type is prepared by packing the toothpaste one by one. A material(110) for packing is paper, foil, or polymer films. The toothpaste contains abrasive as a main ingredient and contains wetting agent, foaming agent, excipient, binder, viscosity modifier, preserver, sweetener, flavoring agent, and additive. The toothpaste also contains sodium chloride, tocopherol acetate, pyridoxine hydrochloride, amino carproic acid, allantoin, or alantoin chlorohydroxy aluminum for preventing gingival diseases or periodontal diseases.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV-2 can enter the brain through different routes, including the olfactory, trigeminal, and vagus nerves, and through blood and immunocytes. SARS-CoV-2 may also enter the brain from the peripheral blood through a disrupted blood-brain barrier (BBB). The neurovascular unit in the brain, composed of neurons, astrocytes, endothelial cells, and pericytes, protects brain parenchyma by regulating the entry of substances from the blood. The endothelial cells, pericytes, and astrocytes highly express angiotensin converting enzyme 2 (ACE2), indicating that the BBB can be disturbed by SARS-CoV-2 and lead to derangements of tight junction and adherens junction proteins. This leads to increased BBB permeability, leakage of blood components, and movement of immune cells into the brain parenchyma. SARS-CoV-2 may also cross microvascular endothelial cells through an ACE2 receptor-associated pathway. The exact mechanism of BBB dysregulation in COVID-19/neuro-COVID is not clearly known, nor is the development of long COVID. Various blood biomarkers could indicate disease severity and neurologic complications in COVID-19 and help objectively diagnose those developing long COVID. This review highlights the importance of neurovascular and BBB disruption, as well as some potentially useful biomarkers in COVID-19, and long COVID/neuro-COVID.
Individuals in this group will be taught home exercises face-to-face in a single session as in the home-based exercise group and will be asked to perform the exercises themselves at home for 3 non-consecutive days a week for 6 weeks. In this group, home exercises will be monitored by phone and recorded with an exercise tracking chart. In addition to home-based exercises, a total of 12 sessions of face-to-face matrix rhythm therapy will be performed, 2 non-consecutive days a week for 6 weeks. Matrix rhythm therapy applications will be applied by a specialist physiotherapist who has received training with the matrix rhythm therapy vibromassage device.
Schizophrenia, a severe psychiatric, neurodevelopmental disorder affecting about 0.29-1 % of the global population, is characterized by hallucinations, delusions, cognitive impairments, disorganized thoughts and speech, leading to significant social withdrawal and emotional blunting. During the 1980s, considerations about diseases that result from complex interactions of genetic background and environmental factors started to appear. One of the critical times of vulnerability is the perinatal period. Concerning schizophrenia, obstetric complications that are associated with hypoxia of the fetus or neonate were identified as a risk. Also, maternal infections during pregnancy were linked to schizophrenia by epidemiological, serologic and genetic studies. Research efforts then led to the development of experimental models testing the impact of perinatal hypoxia or maternal immune activation on neurodevelopmental disorders. These perinatal factors are usually studied separately, but given that the models are now validated, it is feasible to investigate both factors together. Inclusion of additional factors, such as metabolic disturbances or chronic stress, may need to be considered also. Understanding the interplay of perinatal factors in schizophrenia's etiology is crucial for developing targeted prevention and therapeutic strategies.
Provided is a composition for improving male reproductive capability, containing extracts of Sedum sarmentosum BUNGE., Mori Fructus, Dioscorea batatas DECNE., and Rubus coreanus MIQ. as active ingredients. In the present invention, the mixed extracts of Sedum sarmentosum BUNGE., Mori Fructus, Dioscorea batatas DECNE., and Rubus coreanus MIQ. increase concentration of sperm in semen and enhance activities of the sperms. In addition, the mixed extracts increases secretion of sex hormones such as testosterones, luteinizing hormones, or follicle stimulating hormones, thereby exhibiting excellent effects of improving male reproductive capability. Moreover, the present invention provides cost effectiveness in production and user convenience by using natural ingredients.
For standard sleeve gastrectomy (SG), a sleeve was fashioned starting 4 cm proximal to the pylorus using serial applications of an 60 stapler over a 36Fr oro-gastric bougie. A security distance of 15 mm lateral to the esophagus is respected to reduce the risk of high leak.
Our plan is to analyze 3-5 tissue probes acquired from 30 patients with a variety of thoracic malignancies. The investigators will plan to acquire tissue from each type of malignancy including: lung cancer, esophageal cancer and pleural based tumors. Tissue will be acquired in the operating room. Impedance measurements will be collected on multiple sections of excised tissue and will be translated into dielectric properties. After acquisition of data, the investigators will assess the data and continue to acquire patients to obtain significant estimates of overall tissue properties in each type of tumor. After undergoing an informed consent process in accordance with IRB approval, patients with be formally enrolled. All tumor electric property data will be stored securely and remain anonymous of patient identifying data.
Short Physical Activity Assessment Tool was used for evaluating physical activity levels of the participants, mental health status by The Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). Gastrointestinal system symptoms were evaluated by using the Gastrointestinal Symptom Rating Scale (GSRS), sleep quality by the Pittsburg Sleep Quality Index (PSQI) and diet quality by the Healthy Eating Index-2015 (HEI-2015). Measurements were recorded prior to kefir intervention (initial measurement) and post kefir intervention (final measurement) for kefir and control groups.
A pain relieving liquid and pain relieving wine, XIAOTONG liquid and pain relieving wine, are provided. The pain relieving liquid comprises Carthami flos, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Lumbricus, Eupolyphaga Seu Steleophaga, lignum sappan, Myrrha, sanguis Draxonis, Olibanum, radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, and Chinese liquor. Pain relieving liquor comprises Saviae Miltiorrhizae radix, Carthami flos, and Chinese liquor. Second, efficacy detoxify and dissipate nodulation, soften hard mass and detumescence, calm wind and stop convulsion, promote blood circulation and remove blood stasis, dredge meridian passage, warm meridians and relieve pain. Thirdly, the medicine is mainly used for treating sciatica, muscle and bone pain and impotence. Fourthly, the using method comprises the following steps: 1. the pain relieving liquid medicinal liquor is lightly applied to the pain part 3-5 times a day for treating sciatica, muscle and bone pain, the application times can be increased when the pain part is serious, and 25-50 g of pain relieving liquor is orally taken every day. 2. For treating impotence, pain relieving liquid is applied to penis lightly 3-5 times a day, and 25-50 g of pain relieving wine is taken orally at the same time every day.
The invention discloses a mulberry and chrysanthemum tea beverage and a preparation method thereof, wherein the beverage comprises the following components in percentage by weight: 0.1 to 10 percent of mulberry leaf, 0.1 to 10 percent of chrysanthemum, 0.1 to 10 percent of black tea, 0.1 to 10 percent of liquorice, 0.1 to 10 percent of rehmannia root, 0.1 to 5 percent of sodium cyclamate, 0.1 to 5 percent of litsea cubeba or potassium sorbate and the balance of water. The preparation method comprises cleaning, soaking, decocting, and packaging. The beverage is preserved by using the litsea cubeba; no additional chemical preservative was added. The natural efficacy of the raw materials is kept, and the harm of the chemical preservative to human bodies is reduced. Meanwhile, the addition of the liquorice can also reduce the consumption of the sodium cyclamate. The invention has good taste, has the functions of clearing liver and improving vision, promoting digestion and relieving depression, promoting digestion and the like, and has better health-care effect.
The invention discloses a medical product which uses the traditional Chinese medicine external application and magnetotherapy to treat the trauma or tissue damages of a patient to achieve the effects of easing pains, stopping bleeding, hiding wounds and curing and preventing tetanus, and particularly relates to a band aid capable of easing pain and preventing tetanus by magnetotherapy. The preparation method comprises the steps of boiling Yuzhensan with water, soaking non-woven fabric in the solution, fixing the soaked non-woven fabric and a Nd-Fe-B permanent magnet block to a medical elastic plaster, and covering the product with a non-wound-sticking absorption pad. The medical elastic plaster is also used for adhering to a use part of a human body. The magnetic field intensity of the Nd-Fe-B permanent magnet block is 2500GS+2000GS, wherein the N pole points at the human body squarely. The band aid capable of easing pain and preventing tetanus by magnetotherapy does not need any specialized powered equipment. There is no restriction of use parts and use time. The pain-easing effect is excellent. The prevention of tetanus is also achieved as a bonus. The band aid can be used as the substitute especially for the patients which are positive in a tetanus skin test, and therefore unsuitable to accept tetanus toxoid injection.
ABSTRACT        The invention relates to a chimeric transforming growth factor-.beta.1/.beta.2 comprising the amino acid sequence sub-stantially as depicted in FIG. 1 from about amino acid number 279 to about amino acid residue number 390; a cell containing a nucleotide coding sequence for chimeric transforming growth factor-.beta.1/.beta.2 substantially as depicted in FIG. 1 from about nucleotide number 1 to about nucleo-tide number 1170; and a method for producing chimeric trans-forming growth factor-.beta.1/.beta.2 comprising culturing a host cell containing a nucleotide coding sequence for chimeric transforming growth factor-.beta.1/.beta.2, substantially as depicted in FIG. 1 from about nucleotide number 836 to about nucleo-tide number 1170, under the control of a second nucleotide sequence that regulates gene expression so that a peptide or protein having chimeric transforming growth factor-.beta.1/.beta.2 activity is produced by the host cell; and recovering the chimeric transforming growth factor-.beta.1/.beta.2 from the culture. The chimeric gene product possesses TGF-.beta. biological activity in that it regulates cellular differentiation and proliferation and may be useful in treating cancer and pro-moting wound healing.