anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to an enteric release system for releasing glucosinolate in the colon to increase bioavailability of allyl-isothiocyanate in the body of human subject. It comprises of a) a solid core made of glucosinolate obtained from the extract prepared from prepared from mustard seed, mustard cake or mustard bran or a combination thereof and b) an enteric protective coating over said core. The glucosinolate derived from mustard extract contains 20% to 90% sinigrin which is proved to have anticancer activity. The delivery systems used here includes excipients. It is dispensed in the form of hard gel capsule, soft gel capsule, tablet, beadlets, mini tablet, granule, powder and pills and the dosage ranges from 200 mg to about 2000 mg to a human subject. The enteric coating targets the sinigrin for release in large intestine where sinigrin is converted to AITC and increases its bioactivity.
A method performed by a first microservice processor includes receiving a first user indication from a first computing device from a plurality of computing devices of a second user that indicates that a first user requested a service of the second user. A first user-specific data container object is generated that includes first user-specific data elements associated with the service provided to the first user. First user-specific service-necessity information data objects are obtained from electronic resources. The first user-specific data elements and the first user-specific service-necessity information data objects are inputted into a machine learning engine to obtain ranked reference-claim data objects. A chosen reference-claim data object from the ranked reference-claim data objects is chosen by the second user to justify providing the service to the first user. A first user-specific service-specific-claim data object is built, stored in the first user-specific data container object, and submitted to a second microservice.
It is considered that diabetes-associated dementia is mainly caused by insulin resistance and relative insulin deficiency in the brain. Meanwhile, delivery of drugs to the brain is inhibited by the blood-brain barrier, and therefore, there has been so far no drug that provides excellent drug delivery to the brain. Therefore, there has been no wonder drug for diabetes-associated dementia. LPSs have a high molecular weight and therefore do not pass through the blood-brain barrier. A prophylactic drug or therapeutic drug for diabetes-associated dementia according to the present invention is characterized by containing a lipopolysaccharide as an active ingredient. According to the present invention, it is possible to provide a composition for a drug, food, or the like that has the effect of preventing and treating impairment due to diabetes-associated dementia, by means of a lipopolysaccharide derived from a bacterium belonging to the genus Pantoea. A lipopolysaccharide derived from a bacterium belonging to the family Enterobacteriaceae is confirmed to be safe when used for oral or transdermal administration in the form of food, cosmetics, feed, or the like, and thus can be expected to provide prophylactic and therapeutic effects with a low risk of side effects.
The neuroimaging mechanisms underlying differences in the outcomes of sound therapy for tinnitus patients remain unclear. We hypothesize that abnormal hierarchical architecture is the neuro-biomarker for treatment outcome explanation. We conducted functional connectome gradient analyses on resting-state functional MRI images that acquired before intervention to investigate differences among the patients with effective treatment (ET, n = 27), ineffective treatment (IT, n = 41), and healthy controls (HC, n = 59). General linear models were used to analyze the associations between intergroup differential regions and clinical characteristics. Partial least squares regression was employed to reveal correlations with gene expression. Compared to HC, both ET and IT groups displayed significant differences in the default mode network. Moreover, the ET group exhibited wider gradient range and greater gradient variance. Also, the gradient scores of the differential regions between the ET and HC groups were significantly correlated with Self-rating Anxiety Scale and Self-rating Depression Scale scores, and exhibited positive correlations with the transcriptional profiles of genes related to depression and anxiety. Our results indicated that the abnormalities of ET group, may be more relevant to psychiatric disorders, bringing a higher possible therapeutic potential due to the plasticity of the nervous system. Connectome gradient dysfunction with genetic evidence may serve as an indicator for identifying diverse treatment outcomes of the sound therapy for tinnitus patients before treatment.
Stop Finzala if an arterial or deep venous thrombotic event (VTE) occurs. Stop Finzala if there is unexplained loss of vision, proptosis, diplopia, papilledema, or retinal vascular lesions. Evaluate for retinal vein thrombosis immediately. 

If feasible, stop Finzala at least 4 weeks before and through 2 weeks after major surgery or other surgeries known to have an elevated risk of VTE. 

Start Finzala no earlier than 4 weeks after delivery, in women who are not breastfeeding. The risk of postpartum VTE decreases after the third postpartum week, whereas the risk of ovulation increases after the third postpartum week.

The use of COCs increases the risk of VTE. However, pregnancy increases the risk of VTE as much or more than the use of COCs. The risk of VTE in women using COCs is 3 to 9 per 10,000 woman-years. The risk of VTE is highest during the first year of use of a COC. The risk of thromboembolic disease due to oral contraceptives gradually disappears after COC use is discontinued.

Use of COCs also increases the risk of arterial thromboses such as strokes and myocardial infarctions, especially in women with other risk factors for these events. COCs have been shown to increase both the relative and attributable risks of cerebrovascular events (thrombotic and hemorrhagic strokes), although, in general, the risk is greatest in older (greater than 35 years of age), hypertensive women who also smoke. COCs also increase the risk for stroke in women with underlying risk factors. 

Use COCs with caution in women with cardiovascular disease risk factors.
Almonertinib, as a third-generation EGFR-TKI, has been used for the treatment of advanced non small cell lung cancer. How to improve the progression free survival in advance was a challenge. Our previous study showed that first-line EGFR-TKIs plus microwave ablation had PFS survival advantage versus EGFR-TKIs alone. So we conducted this prospective study to verify the efficacy and safety of the combination in a randomized, controlled, phase II clinical trial. Patients were assigned into two groups.In the experiment group, patients were treated with both Almonertinib and microwave ablation. In the control group, patients were treated with Almonertinib alone. The primary end point was progression free survival. Second endpoints included overall survival and safety.
Starting dose of 500mg rociletinib, taken orally twice daily, with 8 oz (240 mL) of water and with a meal or within 30 minutes after a meal. Tablets should be swallowed whole. Treatment with rociletinib is continuous and each cycle will comprise of 28 days.
Multi-analyte blood test screen in participants with a recent confirmed negative diagnosis of HCC by ultrasound. Participants will be scheduled for a 6 month visit (at least 5 months but no more 9 months form enrollment) for a confirmatory ultrasound.
Both rigid and flexible 3D printed boluses made for each patient. Each is used on alternate days during radiation therapy.
A method for training a machine learning image segmentation algorithm to segment structural features of a blood vessel in a computed tomography (CT) image is described herein. The method comprises receiving a labelled training set for the machine learning image segmentation algorithm. The labelled training set comprising a plurality of CT images, each CT image of the plurality of CT images showing a targeted region of a subject, the targeted region including at least one blood vessel. The labelled training set further comprises a corresponding plurality of segmentation masks, each segmentation mask labelling at least one structural feature of a blood vessel in a corresponding CT image of the plurality of CT images. The method further comprises training a machine learning image segmentation algorithm, using the plurality of NCT images and the corresponding plurality of segmentation masks, to learn features of the CT images that correspond to structural features of the blood vessels labelled in the segmentation masks, and output a trained image segmentation model. The method further comprises outputting the trained image segmentation model usable for segmenting structural features of a blood vessel in a CT image. Further methods are described herein for using the trained image segmentation model to segment structural features of blood vessels, and to establish the training set for training the machine learning image segmentation model. Computing apparatuses and computer readable media are also described herein.
There is a single intervention arm in this study. Target accrual for the intervention is 30 subjects. Subjects receive supplementation with Lactobacillus plantarum strains 299 and 299v.
Background and Purpose: Incidence rates of esophageal cancer vary internationally with the higher rate found in Eastern Asia. Preoperative concurrent chemoradiation therapy (CCRT) for resectable esophageal cancer has been shown to improve overall survival in meta-analyses. Preoperative pulmonary function and functional capacity are known predictive factors for the development of postoperative pulmonary complications in patient undergoing major cancer surgery. Little is known concerning the impacts of preoperative CCRT on pulmonary function and functional capacity in patients with esophageal cancer. The aim of this study is to examine changes of respiratory performance and functional exercise capacity during RT or CCRT, the relations between these changes, and the impacts of these changes on the postoperative outcomes in patients with esophageal cancer.

Method: Patients with newly diagnosed esophageal cancer without metastasis will be recruited from the Far Eastern Memorial Hospital. Demographic data will be obtained from the chart. Respiratory muscle strength will be measured by maximal inspiratory and expiratory pressure. Spirometric variables will be tested by force expiratory volume in one second and forced vital capacity. Dyspnea will be measured using modified Borg scale. Functional exercise capacity will be measured by six minute walk distance. Quality of life will be measured using EORTC QOL-C30 and QOL-OES18 instruments. All the measurements will be repeated weekly during the concurrent therapy period. Repeated measure ANOVA will be used for analyzing difference among various time points. Spearman correlation coefficient will be used to test relationship between multiple variables. For patients who are receiving esophagectomy after CCRT or RT, pulmonary complications and total length of hospital stay will be documented.

Clinical relevance: The results of this study will help to better understand the indications for chest physiotherapy (e.g., respiratory muscle weakness, reduced functional capacity, and their related sequels)
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent an innovative class of antidiabetic agents that have demonstrated promise in mitigating cardiac remodeling. However, the transcriptional regulatory mechanisms underpinning their impact on blood pressure and the reversal of hypertension-induced cardiac remodeling remain largely unexplored. Given this context, our study concentrated on comparing the cardiac expression profiles of lncRNAs and mRNAs between Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). To validate our results, we performed blood pressure measurements, tissue staining, and qRT-PCR. The treatment led to a significant reduction in systolic blood pressure and improved cardiac remodeling by reducing myocardial fibrosis and regulating the inflammatory response. Our examination disclosed that ventricular tissue mRNA, regulated by hypertension, was primarily concentrated in the complement and coagulation cascades and cytokine-cytokine receptor interactions. Compared with SHR, the SGLT2i treatment group was associated with myocardial contraction. Investigation into the lncRNA-mRNA regulatory network and competing endogenous RNA (ceRNA) network suggested that the potential roles of these differentially expressed (DE) lncRNAs and mRNAs were tied to processes such as collagen fibril organization, inflammatory response, and extracellular matrix (ECM) modifications. We found that the expression of Col3a1, C1qa, and lncRNA NONRATT007139.2 were altered in the SHR group and that SGLT2i treatment reversed these changes. Our results suggest that dapagliflozin effectively reverses hypertension-induced myocardial remodeling through a lncRNA-mRNA transcriptional regulatory network, with immune cell-mediated ECM deposition as a potential regulatory target. This underlines the potentiality of SGLT2i and genes related to immunity as promising targets for the treatment of hypertension.
FIELD: medicine. SUBSTANCE: the innovation deals with a disposable absorbing product including an adhesive polysiloxane composition which adheres directly to human skin and could be painlessly removed from it. It is suggested a polysiloxane adhesive composition to be used to adhere products to human skin. It is, also, used to obtain an absorbing disposable product including a polysiloxane adhesive composition and which is obtained due to application of a two-component adhesive composition, where one component contains polysiloxane with functional group of the lowest alkenyl, and the second one includes a hydrogen-bearing polysiloxane copolymer possessing active hydrogen groups. EFFECT: higher efficiency. 10 cl, 1 tbl, 2 dwg, 1 ex
The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition. Finally, the present invention provides an antibody which specifically reacts with BCNG protein.
The present study examined disfluencies in the narratives of Russian-Hebrew bilingual children with Developmental Language Disorder (DLD) and Typical Language Development (TLD) in both Russian (home language) and Hebrew (societal language), with a focus on the independent and combined effects of language disorder and cross-linguistic differences on the rates and loci of disfluencies. Narratives were collected from 44 bilingual children (14 with DLD), ages 5;7-6;6, using a story retelling procedure. The narrative coding system targeted ratios of the following disfluencies (per C-unit): silent pauses, repetitions, self-corrections, and filled pauses. Silent pauses longer than 0.25 sec were identified using PRAAT software© and were classified according to the following durations: more than 0.5 sec, 1 sec, 1.5 sec, and 2 sec. In addition, the loci of pauses (utterance-initial or utterance-internal) and repetitions (content or function words) were coded. Overall, children with DLD and TLD had comparable rates of disfluencies but differed for pauses longer than 0.5 sec and repetition of content words in both languages. For the overall ratio of pauses (more than 0.25 sec), children with and without DLD had more pauses in Russian. Long pauses and repetition of content words reflect difficulties for bilingual children with DLD in dealing with the demands of storytelling, in particular planning processes. A higher ratio of pauses in Russian suggests that they reflect lower proficiency in that language.
AIMS: Many studies demonstrated reproductive damage in men residing in plains who are exposed to hypoxia at high altitudes. However, little is known about mechanisms between male reproductive impairment and hypobaric hypoxia. Hypoxia is one of the reasons for the imbalance of cellular redox system. Ferroptosis, involved in many pathophysiological progresses, is an oxidative damage-related, iron-dependent regulated cell death, which needs exogenous inducer. In our study, we explored the mechanism between hypoxia and male reproductive dysfunction.
MATERIALS AND METHODS: Here, we established animal model simulating hypobaric hypoxia at an altitude of 5000 m and used ELISA, WB, qPCR, flow cytometry and etc. to obtain different results.
KEY FINDINGS: The results demonstrated decrease of plasma testosterone (T) and free testosterone (FT) levels under hypoxia, meanwhile there's decline in sperm counts and sperm motility, coupled with increase in sperm malformation rates. Flow cytometry confirmed significant reduction in Leydig cell numbers. Prussian blue staining showed iron depositions in interstitial testis. Features of ferroptosis such as increased MDA (malondialdehyde) levels, reduced solute carrier family 7 member 11 (SLC7A11, xCT) and glutathione peroxidase 4 (GPX4) expression were observed in testis after hypoxic exposure. Further in vitro experiments, we observed that hypoxia suppressed xCT-GPX4 pathway and enhanced cellular ROS accumulation to lead Leydig cell proliferation activity decline.
SIGNIFICANCE: Our findings firstly indicated that hypoxia leads to male reproductive dysfunction via inducing Leydig cell ferroptosis. This discovery may offer a potential intervention target for addressing male reproductive injuries under hypoxic conditions.
INTRODUCTION: IgA vasculitis diagnosis relies primarily on clinical features and is confirmed by pathological findings. To date, there is no reliable noninvasive diagnostic biomarker.
OBJECTIVE: We aimed to explore the baseline serum metabolome of adult patients with IgA vasculitis to identify potential diagnostic biomarkers.
METHODS: We performed a study comparing the serum metabolome of patients with IgA vasculitis to that of patients with inflammatory condition, namely spondyloarthritis. Serum analyses were performed by high-performance liquid chromatography-mass spectrometry.
RESULTS: Fifty-five patients with IgA vasculitis and 77 controls with spondyloarthritis (age- and sex-matched) were included in this study. The median age of IgA vasculitis patients was 53 years. Two-thirds of patients were female (n = 32). At the time of vasculitis diagnosis, 100% of patients had skin involvement and 69% presented with glomerulonephritis (n = 38). Joint and digestive involvement were observed in 56% (n = 31) and 42% (n = 23) of patients. Four discriminative metabolites between the two groups were identified: 1-methyladenosine, L-glutamic acid, serotonin, and thymidine. The multivariate model built from the serum metabolomes of patients with IgA vasculitis and spondyloarthritis revealed an accuracy > 90%. As this model was significant according to the permutation test (p < 0.01), independent validation showed an excellent predictive value of the test set: sensitivity 98%; specificity 98%, positive predictive value 97% and negative predictive value 98%.
CONCLUSION: To our knowledge, this study is the first to use the metabolomic approach for diagnostic purposes in adult IgA vasculitis, highlighting a specific diagnostic metabolome signature.
Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation. The washing-away type cosmetic composition according to the present invention has an emulsion-like or pearl-lustrous appearance and is mild to the skin owing to reduced adsorption, to the skin, of the surfactant contained in the composition.
Participants to receive 2 computed tomography (CT) scans that are part of their regular cancer care. One (1) scan performed before the start of chemotherapy, and the other at first restaging visit with oncologist. Participant to complete the MD Anderson Symptom Inventory for Gastrointestinal cancer (MDASI-GI) questionnaire at baseline visit, and follow up visit.
Chronic pain is a topic of discussion that is becoming increasingly prevalent among healthcare professionals. With the ever-growing opioid epidemic, there are a variety of discussions on different modes of treatment other than opioid prescription. Pain neuroscience education, or PNE, is one of these alternative treatment options. PNE focuses on a patient's understanding of pain itself and relates this to the current pain they are experiencing. PNE is often a discussion between provider and patient that utilizes a series of stories, metaphors, and examples where pain is described from a point of view that is not strictly medical. Recent literature suggests there is a lack of knowledge regarding pain in the United States, particularly in the Spanish-speaking population. This population is also less likely to seek a physician's advice for pain management. For these reasons, this study will focus on the Spanish-speaking population within the Winchester community. Due to success within prior PNE studies, this study will be conducted through a classroom lecture. The overarching purpose of this study is to examine the change in knowledge of pain in the Spanish-speaking population immediately following a PNE lecture composed of stories, metaphors, and examples about pain. Because Spanish-speaking individuals are less likely to seek out a medical provider, the study may support an additional treatment option for managing chronic pain. Not only will this provide further research to support the benefits of PNE, but there is the potential to modify a participant's perception of their own pain through this educational lecture.