anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Device: Gynecological brachytherapy requiring an Interstitial or ring and tandem insert involves insertion of the needle and applicators with no standard real-time image guidance. Occasionally 2-dimensional ultrasound is used, but it greatly limited by its flat nature, preventing a volumetric view of the needle pathways. Interstitial brachytherapy is done under general anesthesia. The trans-abdominal and trans-rectal standard 2D ultrasound that are used in some cases, will be expanded to 3D dimensional imaging through the use of an investigational device. Pre-procedure imaging in the form of MRI is used to help guide needles insertion as well as the clinical exam. Post-procedure CT is done for radiation planning.
By the time Alzheimer's Dementia (AD) and related disorders are diagnosed, the brain has sustained substantial insult that limits the efficacy of current treatments. Preventive interventions are urgently needed but the majority of prevention studies require large numbers of participants, long follow-up periods, and frequent study visits. It is not feasible for many geriatric patients to attend clinics for treatment on a daily basis due to mobility and transportation restrictions, associated costs, and lack of rural clinic locations. Interventions delivered remotely, or administered within an individual's home, allow for preventative treatments to be made accessible to a wider range of individuals. Thus, the overall goals of this project are to assess the feasibility and impact of designing and implementing an at-home intervention aimed at preventing long-term cognitive decline and improving cognition in individuals currently at-risk for developing AD. These high-risk individuals that will be targeted in this proposal are: (1) older adults with Mild Cognitive Impairment (MCI), (2) older adults with Major Depressive Disorder (MDD), and (3) older adults with MCI and MDD.

The proposed intervention combines cognitive remediation (CR) and non-invasive brain stimulation - transcranial Direct Current Stimulation (tDCS), to be delivered in the participants' home environment. Twenty couples (40 participants) will be recruited, with one member defined as the "patient" and the second member defined as the "caregiver" to the patient. These caregivers will facilitate the delivery of the study intervention (i.e., CR+tDCS). Participants with a diagnosis of MCI or MDD or both, who have a caregiver, will receive open-label, active CR+tDCS over a period of 8 weeks. Both CR and tDCS have been shown to induce neuroplasticity and improve cognition. The aim of this pilot study is to assess the feasibility of delivering these combined interventions at home.
The recommended dose based on controlled trials (see CLINICAL STUDIES) is outlined in the Table below. Ibutilide infusion should be stopped as soon as the presenting arrhythmia is terminated or in the event of sustained or nonsustained ventricular tachycardia, or marked prolongation of QT or QTc.

In a trial comparing ibutilide and sotalol (see CLINICAL STUDIES), 2 mg ibutilide fumarate administered as a single infusion to patients weighing more than 60 kg was also effective in terminating atrial fibrillation or atrial flutter.

In the post-cardiac surgery study (see CLINICAL STUDIES), one or two intravenous infusions of 0.5 mg (0.005 mg/kg per dose for patients weighing less than 60 kg) was effective in terminating atrial fibrillation or atrial flutter.

Patients should be observed with continuous ECG monitoring for at least 4 hours following infusion or until QTc has returned to baseline. Longer monitoring is required if any arrhythmic activity is noted. Skilled personnel and proper equipment (see WARNINGS, Proarrhythmia), such as a cardioverter/defibrillator, and medication for treatment of sustained ventricular tachycardia, including polymorphic ventricular tachycardia, must be available during administration of CORVERT and subsequent monitoring of the patient.
Bupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone. It has the following structural formula:

MARCAINE is available in sterile isotonic solutions with and without epinephrine (as bitartrate) 1:200,000 for injection via local infiltration, peripheral nerve block, and caudal and lumbar epidural blocks. Solutions of MARCAINE may be autoclaved if they do not contain epinephrine. Solutions are clear and colorless.

Bupivacaine is related chemically and pharmacologically to the aminoacyl local anesthetics. It is a homologue of mepivacaine and is chemically related to lidocaine. All three of these anesthetics contain an amide linkage between the aromatic nucleus and the amino, or piperidine group. They differ in this respect from the procaine-type local anesthetics, which have an ester linkage.

MARCAINE—Sterile isotonic solutions containing sodium chloride. In multiple-dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 4 and 6.5 with sodium hydroxide or hydrochloric acid.
The invention discloses a pulse data classification method and device based on semi-supervised discrimination projection. The specific classification method comprises the following steps: 1. pressure pulse data is collected. 2. Preprocessing and extracting features of the data acquired in the step 1. 3. And establishing a semi-supervised discriminating projection model, searching an optimal subspace by using a projection matrix, clustering in the space, marking a non-marked sample, and adding the next training round to realize semi-supervised learning of pulse data. 4. And analyzing the projection matrix, and obtaining the contribution degree of each feature to the current task by solving the 'line normalization two norms' of the projection matrix. The pulse data classifying device is used for realizing the classifying step. The invention provides a tool for classifying the pulse data with high precision through judging the projection method, thereby quantifying the feature importance and obtaining good experimental effect.
Chronic kidney disease is globally recognized as a highly impactful non-communicable disease. The inability of early identification contributes to its high mortality rate and financial burden on affected individuals. Chronic kidney disease of uncertain etiology (CKDu) constitutes a significant global public health concern. This condition does not arise from traditional risk factors such as diabetes, hypertension, or glomerulonephritis. More than 150 articles were analysed to understand risk factors of CKDu. This study aimed to investigate the potential association between dissolved organic compounds, such as Polycyclic Aromatic Hydrocarbons and Humic Acid, and the incidence of CKDu. Through a comprehensive literature review, we identified CKDu clusters worldwide, including notable nephropathies, and explored their potential links with organic compounds. Our analysis revealed that organic compounds can leach from sediments and low-rank lignite deposits into groundwater, subsequently contaminating water supplies and food. These compounds have been implicated in the development of diabetes and increased heavy metal mobility, both of which are risk factors for kidney disease. Our findings suggest that exposure to organic compounds may contribute to the etiology of CKDu, underscoring the need for regular monitoring and establishment of baseline and threshold values in water and soil. We also emphasize the importance of analyzing organic compounds in groundwater in CKDu hotspots and establishing distinct registries for CKD and CKDu implementation.
Folliculitis decalvans and lichen planopilaris phenotypic spectrum has been described as a form of cicatricial alopecia. The aim of this study is to describe the clinical and trichoscopic features and therapeutic management of this condition in a series of patients. A retrospective observational unicentre study was designed including patients with folliculitis decalvans and lichen planopilaris phenotypic spectrum confirmed with biopsy. A total of 31 patients (20 females) were included. The most common presentation was an isolated plaque of alopecia (61.3%) in the vertex. Trichoscopy revealed hair tufting with perifollicular white scaling in all cases. The duration of the condition was the only factor associated with large plaques (grade III) of alopecia (p = 0.026). The mean time to transition from the classic presentation of folliculitis decalvans to folliculitis decalvans and lichen planopilaris phenotypic spectrum was 5.2 years. The most frequently used treatments were topical steroids (80.6%), intralesional steroids (64.5%) and topical antibiotics (32.3%). Nine clinical relapses were detected after a mean time of 18 months (range 12-23 months). Folliculitis decalvans and lichen planopilaris phenotypic spectrum is an infrequent, but probably underdiagnosed, cicatricial alopecia. Treatment with anti-inflammatory drugs used for lichen planopilaris may be an adequate approach.
The invention discloses a traditional Chinese medicine composition for treating chronic cystitis. According to the traditional Chinese medicine, chronic cystitis belongs to the category of stranguria in the medicine. The stranguria is mainly caused by dysfunction of bladder qi transformation due to bladder damp-heat, deficiency of spleen and kidney, kidney yin loss and the like. Therefore, the traditional Chinese medicine composition is prepared by the following raw materials: rust-colored crotalaria herb with roots, jasminum laurifolium, Guangdong lysimachia christinae hance, golden cypress, poria cocos, garden burnet, bighead atractylodes rhizome, rhizoma polygonati, dogwood, fructus alpiniae oxyphyllae and rhizoma dioscoreae. The raw materials are decocted into decoction. According to clinical experiment, the curing rate and the total effective rate respectively reach 70.0% and 97.8% and are obvious better than those of a matched group, so that the traditional Chinese medicine composition is worthy of popularization and application.
PROBLEM TO BE SOLVED: To obtain a hyaluronidase inhibitor hopeful of hyaluronidase degradation inhibitory effect by including, as active ingredient, a polyisoprenylated benzophenone derivative having high hyaluronidase inhibitory activity and high safety as well. SOLUTION: This hyaluronidase inhibitor contains, as active ingredient, a polyisoprenylated benzophenone derivative (e.g. a polyisoprenylated benzophenone derivative, garcinol or isogarcinol, found in plants belonging to the genus Garcinia, family Guttiferae). The above derivative is afforded, for example, by appropriately grinding the fruits, fruit skins, tree or bark of a plant containing the above derivative followed by subjecting the resultant ground product or sap of the plant to extraction with an organic solvent such as ethanol, acetone or hexane. The daily dose of this inhibitor in terms of the above derivative is, for example, 10 mg to 10 g, pref. 50 mg to 5 g or so per adult.
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a serious health issue because of its rising global prevalence and its complications, such as kidney failure and cardiovascular disease (CVD). CKD is mainly diagnosed late or undiagnosed, delaying or missing the initiation of preventive interventions. Screening can prevent or delay progressive kidney function decline and CVD. This article reviews diagnostic tests and risk prediction developments for patients with CKD, highlights key evidence for targeted screening, and provides new insights into population-wide screening.
RECENT FINDINGS: Large cohort studies and clinical trial data established the strong association of albuminuria with CKD outcomes, supporting the role of albuminuria as target of CKD screening and treatment. Significant advances in both risk prediction of CKD and CVD in CKD patients and treatment options provided new evidence for the relevance and implications of CKD screening. Guidelines recommend targeted screening in high-risk patients, but evidence suggests limited adherence to guideline recommendations. More recently, population-wide screening has been investigated as another approach, showing potential effectiveness and cost-effectiveness.
SUMMARY: There is increasing evidence for the methods, implications, and effectiveness of CKD screening. Implementing and optimizing screening strategies requires enhanced awareness and understanding of the possibilities for CKD screening within different healthcare systems.
C-C chemokine receptor 5 (CCR5) is a chemokine receptor involved in immune responses and a co-receptor for HIV infection. Recently, CCR5 has also been reported to play a role in synaptic plasticity, learning and memory, and cognitive deficits associated with normal aging, traumatic brain injury (TBI), and HIV-associated neurocognitive disorder (HAND). In contrast, the role of CCR5 in cognitive deficits associated with other disorders, including Alzheimer's disease (AD), is much less understood. Studies have reported an increase in expression of CCR5 or its ligands in both AD patients and AD rodent models, suggesting a correlation between AD and CCR5 expression. However, whether blocking CCR5 in specific brain regions, such as the hippocampus, could improve memory deficits in AD mouse models is unknown. To study the potential causal role of CCR5 in cognitive deficits in AD, we injected soluble Aβ1-42 or a control (Aβ42-1) oligomers in the dorsal CA1 region of the hippocampus and found that Aβ1-42 injection resulted in severe memory impairment in the object place recognition (OPR) and novel object recognition (NOR) tests. Aβ1-42 injection caused an increase in Ccr5, Ccl3, and Ccl4 in the dorsal hippocampus, and the expression levels of CCR5 and its ligands remained elevated at 2 weeks after Aβ1-42 injection. Knocking down Ccr5 in the CA1 region of dorsal hippocampus reversed the increase in microglia number and size in dorsal CA1 and rescued memory deficits. These results indicate that CCR5 plays an important role in modulating Aβ1-42-induced learning and memory deficits, and suggest that CCR5 antagonists may serve as a potential treatment to improve cognitive deficits associated with AD.
The patient uses the Brain Computer Interface (BCI) device in the ICU for communication for 2 hours a day for 3 consecutive days. The patient then uses a communication picture board for 2 hours a day for 3 consecutive days on the same days that the BCI device is used for comparison.
A preparation method of a traditional Chinese medicine lotion for treating spontaneous perspiration bedsore belongs to the technical field of traditional Chinese medicine preparation methods. Present methods for treating spontaneous perspiration bedsore are to use sulfanilamide and antibiotic but have an disadvantage of great toxic and side effect. The technical scheme provided by the invention comprises the following steps of: taking wheat, polyghace seche, longan aril, glehnia root, bighead atractylodes rhizome, Radix Paeoniae Alba, Dolichos lablab L, American ginseng, Radix ophiopogonis, red bayberry, hen egg yolk, wolfberry, Radix Codonopsis, mulberry fruit, Radix Astragali, Polygonatum sibiricum Red., Sarcandra glabra, ovate tylophora root and rhizome, cudweed herb, Asiatic Toddalia Root, pawpaw, roughhair fig root, cortex acanthopanacis, achyranthes root, gartersnake, Blumea balsamifera, Chinese Photinia Leaf Folium Photiniae, serissa serissoides, cerealose and licorice; immersing the above traditional Chinese medicines into water; decocting on slow fire and removing slag. The decocted liquid medicine is the traditional Chinese medicine lotion for treating spontaneous perspiration bedsore. The preparation method has advantages of simple preparation, little toxic and side effect of the prepared liquid medicine and short treatment course. The traditional Chinese medicine can be applied to simultaneously avoid adverse reaction, anaphylactic reaction and toxic response caused by western medicines.
Microglia, the CNS-resident immune cells, are implicated in many neurological diseases. Nearly one in six of the world's population suffers from neurological disorders, encompassing neurodegenerative and neuroautoimmune diseases, most with dysregulated neuroinflammation involved. Activated microglia become phagocytotic and secret various immune molecules, which are mediators of the brain immune microenvironment. Given their ability to penetrate through the blood-brain barrier in the neuroinflammatory context and their close interaction with neurons and other glial cells, microglia are potential therapeutic delivery vehicles and modulators of neuronal activity. Re-engineering microglia to treat neurological diseases is, thus, increasingly gaining attention. By altering gene expression, re-programmed microglia can be utilized to deliver therapeutics to targeted sites and control neuroinflammation in various neuroinflammatory diseases. This review addresses the current development in microglial engineering, including genetic targeting and therapeutic modulation. Furthermore, we discuss limitations to the genetic engineering techniques and models used to test the functionality of re-engineered microglia, including cell culture and animal models. Finally, we will discuss future directions for the application of engineered microglia in treating neurological diseases.
PROBLEM TO BE SOLVED: To prevent the colouring of the hair tonic blended with minoxidil, with the lapse of time, by substantially constituting the material of a container, which includes mninoxidil as a content of polyethylene terephthalate plastic. SOLUTION: The material of a container is a polyethylene terephthalate plastic mainly composed of a base polymer including not less than 50% of a polymer component using a terephthalic acid or a dimethyl ester thereof, and ethylene glycol as the starting materials. The plastic of a degree satisfying the standard reference of food additives, a ministerial ordinance related to dairy products or FDA standard in U.S.A can be used. The plastic of the other polyester can be blended, and any polyethylene terephthalate can be substantially used. The minoxidil has high pharmacological activity, so that the dose per day requires accuracy, so that a quantitative extraction type container is needed. The polyethylene terephthalate is also preferable for the quantitative extraction type container.
The present invention provides a Funingkang thin-coating tablet and a preparation method thereof. The Funingkang thin-coating tablet belongs to a medicinal composition. The present invention particularly relates to a medicine prepared by using plant Chinese medicines as raw materials and a preparation method thereof. The medicinal composition is a preparation prepared from medicines such as ginseng, barbary wolfberry fruit, Chinese angelica, prepared rehmannia root, red peony root, cornel, common anemarrhena rhizome, phellodendron bark, tree peony bark, grassleaf sweetflag rhizome, etc. The preparation method comprises steps such as pulverization, volatile oil extraction, concentration by aqueous extract, granulation, tablet press, the fabrication of film-coating solution, film coating, etc. The medicine has the advantages that the medicine reduces production cost and is favorable to environmental protection; the medicine enlarges applicable people range and is particularly suitable for diabetic patients; by improving the quality standard, the medicine is favorable to quality control.
The invention provides a healthcare wet tissue with antimicrobial and anti-acne functions. The invention belongs to the technical field of wet tissues. The wet tissue comprises high-quality non-woven fabric and an impregnating liquid, wherein the impregnating liquid comprises components of, by weight: 20-30 parts of a pure natural plant chamomile, 15-20 parts of natural aloe juice, 5-10 parts of weeping forsythia fruit, 3-6 parts of nano-grade pearl powder, 1-5 parts of mung bean powder, 5-10 parts of lavender essential oil, 5-8 parts of natural propolis, and 10-15 parts of pure water. According to the invention, no chemical substance is added to the formula. The materials are all extracted from natural plants. The wet tissue is mild, and causes no irritation to skins. Natural propolis has a natural healthcare function upon skins.
The antirheumatic agent (I) is obtd. from the juice of cabbage leaves and also contains olive oil to give the mixt. the right consistency. It is pref. in the form of a salve, which contains (in addition to the olive oil) an emulsifier and a preservative. Preferred amts. are: 10-80 wt.% leaf extract/juice and 10-80 wt.% olive oil; ideally the salve contains a total of 5-80 (10-40) wt.% olive oil and emulsifier. The olive oil is pref. cold-pressed. USE/ADVANTAGE - (I) alleviates inflammation and pain associated with rheumatism. It can also be used in cases of lumbago, migraine, headache, tendon inflammation, dislocation and swelling. If necessary the salve can be wrapped in tissues and used overnight as a compress.
Aim: The purpose of this clinical study is to investigate the effect of a non-resorbable polytetrafluoroethylene (PTFE) membrane on immediate implant placement in the esthetic zone.

Material and Methods: Systemically healthy subjects presenting with a hopeless tooth in the maxillary premolar or anterior region will be recruited in the study. Following a minimally traumatic tooth extraction, subjects will be randomly distributed into one of two treatment groups, a Membrane (Test) or a No Membrane (Control) group. Both groups will receive immediate placement of an implant along with placement of a bone graft material to fill the spaces around the implant. Sites in the test group will receive a non-resorbable PTFE membrane over the socket, whereas those in the control group will receive a collagen dressing over the socket. At sites in the test group, the membrane will be removed at 4 weeks. A second stage surgery and placement of a provisional restoration will be carried out 4 months after implant placement. Final restorations will be placed 3 months after placement of the provisional restoration. Clinical and radiographic measurements will be performed at baseline, implant placement, placement of provisional and final restorations and at the 5-month recall visit.
* Take amiodarone hydrochloride tablets exactly as prescribed by your doctor.
  * The dose of amiodarone hydrochloride tablets you take has been specially chosen for you by your doctor and may change during treatment. Keep taking your medicine until your doctor tells you to stop. Do not stop taking it because you feel better. Your condition may get worse. Talk with your doctor if you have side effects.
  * Your doctor will tell you to take your dose of amiodarone hydrochloride tablets with or without meals. Make sure you take amiodarone hydrochloride tablets the same way each time.
  * Do not drink grapefruit juice during treatment with amiodarone hydrochloride tablets. Grapefruit juice affects how amiodarone hydrochloride tablets are absorbed in the stomach.
  * Taking too many amiodarone hydrochloride tablets can be dangerous. If you take too many amiodarone hydrochloride tablets, call your doctor or go to the nearest hospital right away. You may need medical care right away.
  * If you miss a dose, do not take a double dose to make up for the dose you missed. Continue with your next regularly scheduled dose.