anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a preparation method of graphene quantum dots and application of the graphene quantum dots in preparation of a medicine for treating non-alcoholic fatty liver disease. The invention takes the graphene quantum dots as active ingredients, and has the following advantages in the medicines for preventing, relieving and/or treating fatty liver and related diseases: 1. the drug effect is obvious, the graphene quantum dots can obviously inhibit lipid accumulation in L02 cells, and obvious change can be seen at 20 mu g/ml. 2. The graphene quantum dots can regulate lipid metabolism related genes of Fasn and Scd1, have an inhibition effect on inflammatory factors such as Il6 and Tnf alpha, and show an anti-inflammatory effect. 3. The graphene quantum dots have good biocompatibility, show no obvious toxic or side effect in long-term administration pathology and blood biochemical indexes, and overcome the problem of high toxicity of graphene materials in biological application.
In the Phase III, 1000 adult subjects will be assigned to receive the vaccine against COVID-19 BNT162b2 30μg/0.3mL intramuscular (deltoid), booster, 1 dose. All the population will be evaluated for safety. Of them, 250 will be evaluated for immunogenicity only.
BACKGROUND: Existing models for predicting that biochemical recurrence (BCR) will occur in patients after radical prostatectomy (RP) vary in their predictive results from magnetic resonance imaging (MRI). This study aimed to assess the predictive value of preoperative prostate-specific antigen (PSA) levels combined with MRI features in determining BCR following radical prostatectomy.
METHODS: A retrospective analysis was conducted on a cohort comprising 102 patients who underwent radical prostatectomy at our hospital between January 2019 and December 2019. On the basis of the outcomes observed during a 4-year follow-up after surgery, the patients were categorised into BCR group (n = 52) and non-BCR group (n = 50). Differences in preoperative PSA levels and MRI characteristics between the two groups were compared, and factors influencing postoperative BCR were analysed. The receiver operating characteristic curve was drawn, and the sensitivity, specificity, area under the curve (AUC) and Youden index were calculated to observe the predictive value of the combination of preoperative PSA level and MRI features for BCR following radical prostatectomy.
RESULTS: Logistic regression analysis showed that preoperative PSA level, postoperative Gleason score, data system (Prostate Imaging-Reporting and Data System (PI-RADS)) score and clinical T stage were independent risk factors for BCR in patients following radical prostatectomy, with odds ratio (OR) greater than 1. The AUC value of preoperative PSA level combined with PI-RADS score was 0.921, surpassing the AUC values of 0.783, 0.822, 0.617 and 0.608 predicted by preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage alone, respectively.
CONCLUSIONS: Postoperative BCR in patients with prostate cancer undergoing radical prostatectomy is associated with preoperative PSA level, postoperative Gleason score, PI-RADS score and clinical T stage. The combination of preoperative PSA level and MRI features can improve the predictive efficiency for postoperative BCR.
A substance capable of stimulating the movement of digestive tract, comprisi ng a compound of the formula: (I) (active substance .alpha. and active substanc e .beta. being stereoisomers), which substance is derived from natural product s and hence causes no side effects, is highly safe even when continuously used for a prolonged period of time and can be widely employed as additives to refreshments, etc.; and a refreshment containing an additive comprising the stimulating substance. In particular, a digestive tract movement stimulating substance capable of acting on muscarine M3 receptor, obtained from beer through isolation and purification, which substance is one having drinkabili ty stimulating effect; and a composition from natural products or natural processed products, comprising the above substance. The thus provided substance or composition is used as an additive to refreshment, thereby providing a refreshment capable of stimulating the movement of digestive tra ct.
The role of wound protectors in laparoscopic surgeries is highly controversial in the literature. Some studies demonstrate their benefit in reducing the rate of surgical site infections; however, these results are not reproducible across all procedures. In addition to protecting the operative wound, these devices can be used at sites of surgical specimen extraction in laparoscopic procedures. Several commercially available devices serve this purpose but are scarcely available in resource-limited settings. One of the reasons for this limitation is the cost of the device. In this technical note, we aim to provide a cost-effective option utilizing materials readily available in the operating room and with a simple fabrication process.
The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. While transporter-dependent efflux of some lipophilic substrates across the BBB shows circadian variation due to rhythmic transporter expression, basal transporter-independent permeability and leakage is nonrhythmic. Whether daily timing influences BBB permeability in response to inflammation is unknown. Here, we induced systemic inflammation through repeated LPS injections either in the morning (ZT1) or evening (ZT13) under standard lighting conditions; we then examined BBB permeability to a polar molecule that is not a transporter substrate, sodium fluorescein. We observed clear diurnal variation in inflammatory BBB permeability, with a striking increase in paracellular leak across the BBB specifically following evening LPS injection. Evening LPS led to persisting glia activation as well as inflammation in the brain that was not observed in the periphery. The exaggerated evening neuroinflammation and BBB disruption were suppressed by microglial depletion or through keeping mice in constant darkness. Our data show that diurnal rhythms in microglial inflammatory responses to LPS drive daily variability in BBB breakdown and reveal time of day as a key regulator of inflammatory BBB disruption.
Participants in this group will be given combined exercises consisting of aerobic exercise, strengthening exercise and stretching exercise. They will rest for 10-15 minutes in a relaxation position only. The studies will be carried out under the supervision of a physiotherapist.
<P>PROBLEM TO BE SOLVED: To provide medical charcoal being provided with sufficient adsorption and deodorization functions even in a small quantity and having guaranteed source and quality and a method for producing such medical charcoal and to specifically provide medical charcoal comprising activated bincho charcoal and a method for producing such medical charcoal.  <P>SOLUTION: Kishu bincho charcoal used as a charcoal material is coarsely crushed (within 4 meshes) with a ceramic knife. Steam at a temperature of between 500 to 1,300°C is sprayed to 50,000 g of the charcoal material with partial pressure of between 100 and 200 kPa for 5 to 30 minutes. The composition ratios of the steam gas are steam (H<SB>2</SB>O) ranging from approximately 5 to 100 vol.%, carbon dioxide ranging from approximately 5 to 100 vol.%, and nitrogen ranging from approximately 0 to 95 vol.%. Subsequently, air at normal temperature is sprayed for approximately 1 to 10 minutes. These procedures are determined to be one set that is repeated 10 to 120 sets. After washing, the products are finely crushed to have a particle size (average diameter of 12 microns) appropriate for use as cosmetic using a ceramic knife.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The goal of this study is to evaluate two sets of interventions to increase acceptance of hepatitis B virus (HBV) vaccination in patients attending sexually transmitted disease (STD) clinics. The 1st specific aim is to assess the effect of message-framing on vaccine acceptance. Framing theory suggests that positively framed messages (i.e., benefits of getting vaccine) are more effective than negatively framed messages (i.e., dangers of not getting vaccine) in stimulating preventive health behaviors. Research on Framing Theory and engagement in health behaviors suggests also that the effects may be moderated by other attitudinal factors, including perceived risk of the behavior and degree of involvement in the message. The 2nd aim is to evaluate the effect of provider-based interventions. Prior research suggests that recommendations by health providers are very important in patients' decisions regarding acceptance of health care procedures. Patients (18 years and older) will be recruited and followed from Chicago and Indianapolis STD clinics during routine medical visits. An audio computer-assisted self-interview (A-CASI) will cover demographics, risk behaviors, and perceived risk associated with vaccination. Subjects then will be randomized to receive a gain-framed, loss-framed, or information only message regarding HBV immunization (also delivered by A-CASI). Upon completion of the message-framing intervention, subjects will complete additional attitude questions via A-CASI. Upon completion of the A-CASI subjects will be randomly assigned to one of two provider intervention conditions: 1. vaccine offered or 2. vaccine recommended. For both conditions free HBV immunization will be provided by a nurse practitioner. Subsequently, postcard reminders will be sent and phone call reminders made for follow-up appointments for those receiving the first and second doses of vaccine. The primary outcome measure is HBV vaccination.
EndoArt NiTi Pedo Gold file is specially designed for primary teeth. 18mm length consists of 4 different rotary tools: (15/06) white, (20/04) yellow, (25/04) red, (30/04) blue. The cross-sections of the files are triangular, and Gold wire technology is used in the production phase. were produced using Thus, a titanium oxide layer on the surface of the instrument Happened. Thus, it is more flexible and more flexible than conventional NiTi alloys. resistant and 2 times better cyclic fatigue resistance than conventional files exists. EndoArt NiTi Pedo Golf File; EndoArt NiTi Pedo Gold #15, #20, and #30 files were used with the crown down technique with the appropriate speed and torque values recommended by the manufacturer (350 rpm and 2.0 Ncm).
The present invention relates to a method for producing a shampoo using Thymus quinquecostatus Celak. The method comprises: a freezing step (S10) of rapidly cooling extracted Thymus quinquecostatus Celak. at 30-50C below zero; a drying step (S20) of sublimating and drying the frozen Thymus quinquecostatus Celak. in a vacuum state for 15-25 hours; a preparing step (S30) of pulverizing a dried ingredient of the Thymus quinquecostatus Celak. to 100-300 mesh, and composing a powder-state Thymus quinquecostatus Celak. extract raw ingredient (2a) or a liquid crude oil-state Thymus quinquecostatus Celak. extract raw ingredient (2b); and a producing step (S40) of producing a final shampoo liquid (45) by mixing the powder-state Thymus quinquecostatus Celak. extract raw ingredient (2a) and the liquid crude oil-state Thymus quinquecostatus Celak. extract raw ingredient (2b) at a ratio of 0.1-3 wt% versus 97-99.9 wt%. Accordingly, hair and scalp are cleaned, so freshness is ensured and scalp irritation and scalp stress are alleviated and soothed. Thus, the health of the scalp is maintained. Also, bodily waste is removed, so a balance in sebum secretion is maintained. Nutrition and moisture are supplied to hair, and the health of the hair is maintained. Dandruff or pruritus is alleviated, and domestic native plants having strong flower fragrances are processed while being extracted. Therefore, shampoos can be mass-produced, and a fragrance emitting function and a predetermined sterilizing effect are shown when the shampoo of the present invention is used.
PURPOSE: A composition containing an anti-diabetic peptide-PEG-albumin conjugate is provided to reduce renal clearance rate and to improve blood glucose reduction. CONSTITUTION: An anti-diabetic peptide-PEG-albumin conjugate is prepared using polyethylene glycol(PEG) as a leakage compound. PEG is modified to succinimidyl succinate, succinimidyl propionate, succinimidyl butanoate, N-hydroxy succinimide, or benzotriazole carbonate at one end and is modified to maleimide or OPSS at the other end. The anti-diabetic peptide is synthetic type or gene recombination type. The anti-diabetic peptide is GLP-1, exendin-4, insulin or agonist, derivative, fragment, variant, or mixture thereof. A composition for reducing blood glucose contains the diabetic peptide-PEG-albumin conjugate as an active ingredient.
Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across proteomes in all kingdoms of life, help to shape biological functions and are involved in numerous diseases. IDRs populate a diverse set of transiently formed structures and defy conventional sequence-structure-function relationships1. Developments in protein science have made it possible to predict the three-dimensional structures of folded proteins at the proteome scale2. By contrast, there is a lack of knowledge about the conformational properties of IDRs, partly because the sequences of disordered proteins are poorly conserved and also because only a few of these proteins have been characterized experimentally. The inability to predict structural properties of IDRs across the proteome has limited our understanding of the functional roles of IDRs and how evolution shapes them. As a supplement to previous structural studies of individual IDRs3, we developed an efficient molecular model to generate conformational ensembles of IDRs and thereby to predict their conformational properties from sequences4,5. Here we use this model to simulate nearly all of the IDRs in the human proteome. Examining conformational ensembles of 28,058 IDRs, we show how chain compaction is correlated with cellular function and localization. We provide insights into how sequence features relate to chain compaction and, using a machine-learning model trained on our simulation data, show the conservation of conformational properties across orthologues. Our results recapitulate observations from previous studies of individual protein systems and exemplify how to link-at the proteome scale-conformational ensembles with cellular function and localization, amino acid sequence, evolutionary conservation and disease variants. Our freely available database of conformational properties will encourage further experimental investigation and enable the generation of hypotheses about the biological roles and evolution of IDRs.
INTRODUCTION: Acute type A aortic dissection (ATAAD) is one of the most critical emergencies in cardiovascular surgery. Additional complications such as organ malperfusion can significantly decrease the chances of survival. Despite promptly performed surgical treatment, impaired organ perfusion may persist, thus close postoperative monitoring is recommended. But, is there a surgical consequence due to the existence of a preoperatively known malperfusion and is there a correlation between pre-, peri- and postoperative levels of serum lactate and proven malperfusion?
METHODS: Between 2011 and 2018, 200 patients (66% male; median age: 62.5 years; interquartile range: +/-12.4 years) that received surgical treatment at our institution for an acute dissection DeBakey type I were enrolled in this study. The cohort was divided into two groups according to the preoperative existence of malperfusion and non-malperfusion. At least one kind of malperfusion occurred in 74 patients (Group A: 37%), while 126 patients (Group B: 63%) showed no evidence of malperfusion. Furthermore, lactate levels of both cohorts were differentiated into four periods: preoperative, intraoperative, 24 hours after surgery, and 2-4 days after surgery.
RESULTS: The patients' status differed significantly prior to surgery. Group A (malperfusion) showed an elevated requirement for mechanical resuscitation (A: 10.8%; B: 5.6%; p: 0.173), were significantly more often admitted in an intubated state (A: 14.9%; B: 2.4%; p: 0.001) and showed higher incidences of stroke (A: 18.9% (n = 149); B: 3.2% (n = 4); p: 0.001). Levels of serum lactate from the preoperative period until days 2-4 were significantly increased in the malperfusion cohort at all times.
CONCLUSIONS: Preexisting malperfusion due to ATAAD may significantly increase the chance of early mortality in patients with ATAAD. Serum lactate levels were a reliable marker for inadequate perfusion from admission until day 4 after surgery. Despite this, early intervention survival in this cohort remains limited.
Subjects received Haloperidol Tablets 2 mg Test Product (Cycle Pharmaceuticals Ltd). Subjects also received as pre-medication Benztropine Mesylate Tablets, USP (1 mg every 10 to 12 hours), beginning 4 to 6 hours before dosing with IMP and continued for a total of 4 doses.
Initiation of everolimus (8-12 ng/mL) with discontinuation of CNI. Everolimus(RAD001) 4 mg initial daily dose.
Aiming to discover effective and safe non-steroidal anti-inflammatory agents, a new set of 1,2,4-triazole tetrahydroisoquinoline hybrids 9a-g, 11a-g and 12a-g was synthesized and evaluated as inhibitors of COX-1 and COX-2. In order to overcome the adverse effects of highly selective COX-2 and non-selective COX-2 inhibitors, the compounds of this study were designed with the goal of obtaining moderately selective COX-2 inhibitors. In this study compounds 9e, 9g and 11f are the most effective derivatives against COX-2 with IC50 values 0.87, 1.27 and 0.58 µM, respectively which are better than or comparable to the standard drug celecoxib (IC50 = 0.82 µM) but with lower selectivity indices as required by our goal design. The results of the in vivo anti-inflammatory inhibition test revealed that compounds 9e, 9g and 11f displayed a higher significant anti-inflammatory activity than celecoxib at all-time intervals. In addition, these compounds significantly decreased the production of inflammatory mediators PGE-2, TNF-ɑ and IL-6. Compounds 9e, 9g and 11f had a safe gastric profile compared to indomethacin, also compound 11f (ulcerogenic index = 1.33) was less ulcerous than the safe celecoxib (ulcerogenic index = 3). Moreover, histopathological investigations revealed a normal architecture of both paw skin and gastric mucosa after oral treatment of rats with compound 11f. Furthermore, molecular docking studies were performed on COX-1 and COX-2 to study the binding pattern of compounds 9e, 9g and 11f on both isoenzymes.
The investigators will deliver an online intervention focused on safety planning (STARS). The intervention content includes life skills interactive modules across 14 domains, a goal tracker, referral to community resources, and scheduling of peer mentoring sessions.
NEW MATERIAL:A protein separated from body fluid of larva of an insect belonging to Polyphaga suborder, having a molecular weight of about 42,000 and an isoelectric point (pI) of 8.9-9.0, resistant to trypsin and having carcinostatic activity. USE:A chemotherapeutic agent for cancer having direct cytotoxicity to cancer cell. PREPARATION:A semitransparent viscous liquid is extracted by thrusting an injection needle to the dorsal vessel of larva of Allomyrina dichotoma (a beetle). The liquid is centrifuged to remove hematocyte, heated, dialyzed with water using a cellulose dialysis membrane and subjected to salting-out with an aqueous solution of ammonium sulfate having a concentration of >=40% saturation to precipitate >=90% of protein. The precipitate is separated by filtration and treated by ion-exchange chromatography. The unadsorged fraction is subjected to reversed phase liquid chromatography to obtain the objective purified protein.
<P>PROBLEM TO BE SOLVED: To search for and provide a new gene associated with multidrug resistance in cancer and its protein, elucidate functions of the gene and its protein and to provide a method for examining the gene and an antibody against the protein and further a method for examining and diagnosing the cancer using the gene and the antibody.  <P>SOLUTION: The new protein (RB1CC1) or a polypeptide and a gene thereof are present in the nucleus of a human or an animal cell and have transcription factor functions and/or functions to induce the expression of a retinoblastoma-1 gene (RB1 gene) or its gene product. An amino acid sequence and a cDNA sequence thereof are then determined and the gene is amplified and detected by using a primer hybridizable with the new gene. Thereby, the expression, mutation, etc., of the new gene are examined. The relationship thereof with proliferation of cancer cells is found out to thereby examine the cancer. The antibody against the new protein is prepared to detect the new protein with the antibody. As a result, the relationship between the new protein and the proliferation of the cancer cells is found out to thereby examine the cancer.  <P>COPYRIGHT: (C)2004,JPO
A computer-implemented system includes a treatment apparatus manipulated by a patient while performing an exercise session and a patient interface that receives a virtual avatar. The patient interface presents the virtual avatar. The virtual avatar uses a virtual representation of the treatment apparatus to guide the patient through an exercise session. A server computing device provides the virtual avatar of the patient to the patient interface and receives a message pertaining to a trigger event. The message includes a severity level of the trigger event. The server computing device determines whether a severity level of the trigger event exceeds a threshold severity level, and responsive to determining the severity level of the trigger event exceeds the threshold severity level, replaces on the patient interface the presentation of the virtual avatar with a presentation of a multimedia feed from a computing device of the medical professional.
Introduction and purpose: There are studies in the literature that associate oxytocin level with postpartum depression. This study was carried out to investigate the relationship between oxytocin levels measured during pregnancy and postpartum depression symptoms.

Method: The study was conducted with 70 women who met the research criteria. Data collection was done in two interviews. The first meeting is 30-38 at the week of gestation, the second interview is 4-12 at the week of postpartum. It was done between weeks. In each interview, a data collection form was applied first and then a saliva sample was taken. Data collection form; The questions prepared by the researchers consisted of the Edinburgh Postnatal Depression Scale (EPDS) and Beck Depression Inventory (BDI). The data were analyzed using SPSS 22.0 program and the significance value was taken as p \<0.05.