anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The study participants will be randomly assigned to receive Tiotropium bromide,single dose (inhalation capsule - 18 mcg) over the course of 24 hours on day one of visit 1 or during visit 3.On the day of the first scheduled visit ( visit 1 ),study participants will be asked to arrive between 12-1 pm at the pulmonary laboratory at the JJPVAMC (7A-13). Baseline blood pressure (BP) and heart rate (HR) measurements will be obtained prior to drug administration. Tiotropium bromide capsule containing active ingredients will be orally inhaled through a SPIRIVA HandiHaler. Measurements of exhaled nitric oxide, pulmonary function ( spirometry , static lung volumes and specific airway conductance) will be performed at 20 and 24 hours. The same schedule will be followed for visits 3 and 4;vists 3 and 4 will be scheduled between 14 and 21 days after visit 2.
The interaction between bacteria and the intestinal mucus is crucial during the early pathogenesis of many enteric diseases in mammals. A critical step in this process employed by both commensal and pathogenic bacteria focuses on the breakdown of the protective layer presented by the intestinal mucus by mucolytic enzymes. C. perfringens type G, the causative agent of necrotic enteritis in broilers, produces two glycosyl hydrolase family 18 chitinases, ChiA and ChiB, which display distinct substrate preferences. Whereas ChiB preferentially processes linear substrates such as chitin, ChiA prefers larger and more branched substrates, such as carbohydrates presented by the chicken intestinal mucus. Here, we show via crystal structures of ChiA and ChiB in the apo and ligand-bound forms that the two enzymes display structural features that explain their substrate preferences providing a structural blueprint for further interrogation of their function and inhibition. This research focusses on the roles of ChiA and ChiB in bacterial proliferation and mucosal attachment, two processes leading to colonization and invasion of the gut. ChiA and ChiB, either supplemented or produced by the bacteria, led to a significant increase in C. perfringens growth. In addition to nutrient acquisition, the importance of chitinases in bacterial attachment to the mucus layer was shown using an in vitro binding assay of C. perfringens to chicken intestinal mucus. Both an in vivo colonization trial and a necrotic enteritis trial were conducted, demonstrating that a ChiA chitinase mutant strain was less capable to colonize the intestine and was hampered in its disease-causing ability as compared to the wild-type strain. Our findings reveal that the pathogen-specific chitinases produced by C. perfringens type G strains play a fundamental role during colonization, suggesting their potential as vaccine targets.
According to various aspects of the present disclosure, a system and associated method and functions to anticipate a need of a user are disclosed. In some embodiments, the disclosed system includes a data acquisition unit, a prediction unit, and an operation unit. The data acquisition unit is configured to detect user information, the user information including physiological and non-physiological data associated with the user. The prediction unit is operatively connected to the data acquisition unit to receive the user information, and is configured to anticipate a user need (e.g., need for medical assistance, need for language translation support, etc.) based on pre-defined user preferences, as well as on the physiological data or the non-physiological data or both. And, the operation unit is configured to automatically perform an operation, without user input, to address the user need (e.g., contact a medical facility, provide a language translation application to the user, etc.).
CMG901 will be administered in treatment cycles once every 3 weeks (Q3W). Dose escalation will be carried out according to a modified 3+3 dose-escalation design. Accelerated dose titration design will be used for the first 2 dose levels (0.3mg/kg and 0.6mg/kg), and then traditional 3+3 dose escalation design will be used for the following levels (1.2mg/kg, 1.8mg/kg, 2.2mg/kg, 2.6mg/kg and 3.0mg/kg).
Hemodynamic coherence plays a critical role in the outcomes of septic shock. Due to the potential negative consequences of microcirculatory disorders on organ failure and clinical outcomes, the maintenance of a balance between the macrocirculation and microcirculation is a topic of significant research focus. Although physical methods and specialized imaging techniques are used in clinical practice to assess microcirculation, the use of monitoring devices is not widespread. The integration of microcirculation research tools into clinical practice poses a significant challenge for the future. Consequently, this review aims to evaluate the impact of septic shock on the microcirculation, the methods used to monitor the microcirculation and highlight the importance of microcirculation in the treatment of critically ill patients. In addition, it proposes an evaluation framework that integrates microcirculation monitoring with macrocirculatory parameters. The optimal approach should encompass dynamic, multiparametric, individualized, and continuous monitoring of both the macrocirculation and microcirculation, particularly in cases of hemodynamic separation.
Glioblastoma (GBM) is the most aggressive and life-threatening brain tumor, characterized by its highly malignant and recurrent nature. DNA damage-regulated autophagy modulator 1 (DRAM-1) is a p53 target gene encoding a lysosomal protein that induces macro-autophagy and damage-induced programmed cell death in tumor growth. However, the precise mechanisms underlying how DRAM-1 affects tumor cell proliferation through regulation of lysosomal function and autophagic flux stability remain incompletely understood. We found that DRAM-1 expressions were evidently down-regulated in high-grade glioma and recurrent GBM tissues. The upregulation of DRAM-1 could increase mortality of primary cultured GBM cells. TEM analysis revealed an augmented accumulation of aberrant lysosomes in DRAM-1-overexpressing GBM cells. The assay for lysosomal pH and stability also demonstrated decreasing lysosomal membrane permeabilization (LMP) and impaired lysosomal acidity. Further research revealed the detrimental impact of lysosomal dysfunction, which impaired the autophagic flux stability and ultimately led to GBM cell death. Moreover, downregulation of mTOR phosphorylation was observed in GBM cells following upregulation of DRAM-1. In vivo and in vitro experiments additionally illustrated that the mTOR inhibitor rapamycin increased GBM cell mortality and exhibited an enhanced antitumor effect.
Subjects identified as having a clinically relevant strength deficit will be asked to participate in physical therapy sessions 3 times per week for 3 weeks. The strengthening program will consist of an individualized, progressive exercise program with an emphasis on increasing lower extremity strength, power, and biomechanics.
UCP participants will receive the same clinical and educational management for candidates for insulin pump or continuous glucose monitoring that is received by similar patients who are not enrolled in this study. The respective endocrinology practices at the enrolling sites all strive to meet or exceed the current American Diabetes Association Standards for Clinical Practice in the management of type 1 diabetes in this population. Thorough patient education is the cornerstone of that care, especially regarding the incorporation of insulin pumps and continuous glucose monitors into the treatment regimen for a given patient.
The research group cooperated with the implementation of narrative nursing. The detailed measures are as follows: ① Establish a narrative nursing special group. ② Narrative data collection. ③ Pay attention to the scientific evaluation of narrative content. ④ Edit the narrative reasonably. ⑤ Strengthen interview intervention. Continuous care for 2 months.
OBJECTIVE: Fungal balls (FB) are the main form of non-invasive fungal rhinosinusitis found in immunocompetent hosts. Bacterial coinfection affects clinical symptoms. We investigated the sinonasal microbiome and inflammatory profiles in FB and chronic rhinosinusitis (CRS) patients.
METHODS: Thirty-three participants were prospectively recruited. Nasal swab samples and sinonasal tissues were collected from controls, and FB and CRS patients. DNA extraction and microbiome analysis using V3-V4 region 16S rRNA sequencing were performed. Inflammatory cytokine levels in the sinonasal tissues, blood eosinophil counts, and serum total IgE were measured.
RESULTS: No significant differences were observed in species richness or evenness measures. The phylogenetic tree demonstrated that the FB samples were different from the controls. The sinus bacteria composition differed among the groups. At the phylum level, Firmicutes in FB were significantly depleted compared with those in CRS, while Proteobacteria were more enriched in FB than that in controls and CRS. At the genus level, in FB, Staphylococcus and Corynebacterium were significantly decreased compared to those in the controls. The prevalence of Haemophilus was the highest in FB. Blood eosinophil counts and IL-5 and periostin levels in the sinonasal tissue of the FB group were significantly lower than those in the CRS group.
CONCLUSIONS: FB patients had different microbiome compositions and fewer type 2 inflammatory profiles than CRS patients did. However, whether these findings cause FB or result from bacterial and/or fungal infection remains unclear. Further studies are needed to reveal how these differences occur and affect the development of FB and clinical symptoms.
PURPOSE:To solubilize a biomembrane protein without denaturing the protein and separate and purify the above-mentioned protein in high purity without damaging the biomembrane, by carrying out gel electrophoresis in the presence of a specific sulfuric acid ester type anionic surfactant at a specified temperature or below. CONSTITUTION:A biomembrane protein, e.g. thylakoid membrane protein of spinach, is subjected to the gel electrophoresis in the presence of an alkyl(alkylphenyl) sulfuric acid ester salt type anionic surfactant, having at least one N atom as a counter ion in the molecule thereof and expressed by the formula ROSO3M (R is 6-22C alkyl or alkylphenyl; M is cation having one or N atoms), e.g. triethanolamine salt of dodecylsulfuric acid, preferably in 0.1-3wt% concentration expressed in terms of aqueous solution concentration, at <=15 deg.C, preferably 0-10 deg.C. Preferably, polyacrylamide gel is used as the gel for the electrophoresis and a buffer solution containing the same ion species as the above-mentioned counter ion is used as the buffer solution. The pH is preferably 4-9, particularly preferably 7.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to oncothoracic surgery, and can be used in treating the patients with metastatic lesion of the lungs. That is ensured by lung perfusion with a solution consisting of blood corpuscles and plasma excluded from blood circulation dissolved in an isotonic solution containing 50 mg of melphalan. The perfusion is enabled at space velocity 180-220 ml/min in the hyperoxic conditions ensured by a membrane oxygenator included in the perfusion loop and receiving oxygen supplied FiO2 100% at space velocity 180-220 ml/minutes. It is combined with high-frequency perfusion lung ventilation with a humidified oxygen mixture FiO2 40 %, Peep+5 cm H2O at frequency 50 to 100 inhales per minute. ^ EFFECT: method allows to intensify antineoplastic activity of the treatment considerably ensured by a combination of cytostatic agents in high doses and pulmonary tissue hyperoxia promoting apoptosis induction preventing potential development of bronchial tubes and pulmonary parenchyma ischemia. ^ 1 dwg, 2 ex
The invention provides an anti-leukemia oral liquid and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The liquid is characterized by comprising, by weight, 4-8 parts of Sculellaria barbata, 2-4 parts of Herba Hedyotis, 6-9 parts of Polygonum cuspidatum, 6-10 parts of Rhizoma Menispermi, 5-8 parts of hairyvein agrimony, 4-7 parts of patrinia scabiosaefolia link, 3-4 parts of Sophora flavescens, 3-6 parts of Patrinia heterophylla, 1-3 parts of  placenta hominis, 7-8 parts of turtle shell, 7-11 parts of indigo naturalis, 8-10 parts of black nightshade, 4-7 parts of Lycium chinensis and 3-6 parts of hawthorn. The preparation method comprises the steps of crushing, drying, extracting, adding culture medium, sealing, fermenting, filtering, separating and purifying. The liquid unprecedentedly solves the difficult problem of leukemia from the aspect of gene repair of cellular molecules. The material of the liquid is easy to find. The prepared liquid can be portable, and can be orally served directly, thus relieving the pain of surgical operation and the side effect brought by the chemical and radiation therapies.
This study aims to analyse the volumetric changes in brain MRI after cochlear implantation (CI), focusing on the speech perception in postlingually deaf adults. We conducted a prospective cohort study with 16 patients who had bilateral hearing loss and received unilateral CI. Based on the surgical side, patients were categorized into left and right CI groups. Volumetric T1-weighted brain MRI were obtained before and one year after the surgery. To overcome the artifact caused by the internal device in post-CI scan, image reconstruction method was newly devised and applied using the contralateral hemisphere of the pre-CI MRI data, to run FreeSurfer. We conducted within-subject template estimation for unbiased longitudinal image analysis, based on the linear mixed effect models. When analyzing the contralateral cerebral hemisphere before and after CI, a substantial increase in superior frontal gyrus and superior temporal gyrus (STG) volumes was observed in the left CI group. A positive correlation was observed in the STG and post-CI word recognition score in both groups. As far as we know, this is the first study attempting longitudinal brain volumetry based on post-CI MRI scans. We demonstrate that better auditory performance after CI is associated with structural restoration in central auditory structures.
PROBLEM TO BE SOLVED: To obtain a composition for external use, capable of reducing characteristic skin irritation by an antiphlogistic-sedative medicine, having sufficient antiphlogistic and analgesic effect, by formulating an antiphlogistic-sedative medicine of phenylacetic acid base, indole-base, etc., with a diphenylimidazole. SOLUTION: This composition comprises any antiphlogistic-sedative medicine of an anthranilic acid base, phenylacetic acid base, indole base, propionic acid base, pyrazolone base, benzothiasin base and sulfonamide base and (B) diphenylimidazole. When indomethacin of indole base is especially used as the component A, reducing effects on skin irritation are shown. The amount of the component A formulated is preferably 0.1 to 6wt.% in the composition (in a stock solution in the case of aerosol). That of the component B is preferably 0.001-6wt.%. The amount of the component B is 0.001-5 pt.wt.% based on 1 pt.wt.% of the component A. The composition for external has preferably pH4-6.5 with respect to reduction of skin irritation and the stability of the formulated agents.
This is a 10-year multi-center, global, observational study to further characterize the safety profile of pegvaliase, including hypersensitivity reactions, long-term safety and tolerability, and the effectiveness of the aRMMs (EU only) in subjects receiving pegvaliase for the treatment of PKU. Subjects for whom a clinical decision has been made that they will receive pegvaliase to treat their PKU within 30 days following the date of enrollment (incident-users) or have previously started treatment with pegvaliase at the date of enrollment (prevalent-users) are eligible for participation in this study. Once the subject has been enrolled, the investigator (ie, subject's primary physician) will be asked to provide information about the subject's medical history, treatment(s) received to manage their blood Phe levels, treatment with pegvaliase, and concomitant medication use. The investigator will also be asked to provide evaluation of the following safety concerns: Acute systemic hypersensitivity reaction, Anaphylaxis, Angioedema, Serum sickness, Severe hypersensitivity reaction, Severe or Persistent arthralgia, Severe injection site reaction, Hypophenylalaninemia and other protocol-defined safety events, following the initiation of pegvaliase therapy. There are no protocol-mandated visits or procedures associated with this study. Enrolled subjects should be followed per routine clinical practice at the institution based upon their diagnosis, with clinical outcomes assessed at regular intervals (typically every month during the induction and titration phases of pegvaliase treatment and every 6 months once the maintenance phase is reached). No experimental treatment or assessments are planned as part of this observational study. An Independent Adjudication Committee (IAC) will periodically review protocol-defined safety events, including Acute systemic hypersensitivity reaction and Serum sickness.
Macrophage polarization divides macrophages into two main cell subpopulations, classically and alternatively activated macrophages (M1 and M2, respectively). M1 polarization promotes osteoclastogenesis, while M2 polarization promotes osteogenesis. The physiological homeostasis of bone metabolism involves a high dynamic balance between osteoclastic-mediated bone resorption and formation. Reportedly, M1/M2 imbalance causes the onset and persistence of inflammation-related bone diseases. Therefore, understanding the research advances in functions and roles of macrophages in such diseases will provide substantial guidance for improved treatment of bone diseases. In this review, we underscore and summarize the research advances in macrophage polarization, and bone-related diseases, such as rheumatoid arthritis, osteoarthritis, and osteoporosis, over the last 5 years. Our findings showed that targeting macrophages and balancing macrophage polarization can effectively reduce inflammation and decrease bone destruction while promoting bone formation and vascular repair. These results indicate that regulating macrophage and macrophage polarization to restore homeostasis is a prospective approach for curing bone-related diseases.
Due to the alcohol and propylene glycol content of this product, this cyclophosphamide product is not indicated for use in pediatric patients [see Indications and Usage (1) and Use in Specific Populations (8.4)]. If treatment with cyclophosphamide is indicated for a pediatric patient, use a different cyclophosphamide product.

The alcohol content in a dose of Cyclophosphamide Injection may affect the central nervous system and should be taken into account for patients in whom alcohol intake should be avoided or minimized. Consideration should be given to the alcohol content in Cyclophosphamide Injection on the ability to drive or use machines immediately after the infusion. Each administration of this cyclophosphamide product at 25 mg/kg/day delivers 146.2 mg/kg of ethanol. For a patient with a BSA of 70 kg, this would deliver 10.23 grams of ethanol. Other cyclophosphamide products may have a different amount of alcohol or no alcohol.

Monitor patients for signs of alcohol intoxication during and after treatment. Counsel patients about the possible effects of the alcohol content in this cyclophosphamide product, including possible effects on the central nervous system.
Epoxy resin systems are widely used materials in various industries due to their high mechanical, chemical, and thermal resistance. These systems are commonly employed as protective coatings, adhesives, and paints, as well as in the manufacturing of composites in the plastics industry. Epoxy components are well-known sensitizers of the skin. A high prevalence of skin sensitization and dermatitis have been reported among workers exposed to epoxy components. It is recommended to use comprehensive protective equipment when handling epoxy components. In the wind turbine industry, tasks involving epoxy handling, such as lamination and filling procedures, are frequently performed. Recent study have shown a sensitization prevalence of 8.9% among workers performing these tasks, while a previous study reported a high sensitization rate of 10.5% to epoxy resins. Despite efforts to find alternatives to epoxy resin systems and improve protective measures, the use of epoxy has increased, and some countries have implemented more stringent regulations, such as Denmark. In Portugal, there are currently no specific regulations regarding epoxy handling, and no certification is required for working with epoxy. Siemens Gamesa Renewable Energy, in Portugal, faces many skin problems among production workers, however numbers are unknown. Therefore, the main purpose of the study is to evaluate the prevalence of skin sensitization and dermatitis among epoxy-exposed workers in the wind Turbine Industry.
The present invention relates to a method for producing transgenic plants, which involves producing hemagglutinin proteins of the H5N1 virus in a highly efficient manner using a plant transformation recombinant vector, wherein said vector can express, in a highly efficient manner, hemagglutinin proteins of the H5N1 virus which is the highly pathogenic avian influenza virus, and can transport proteins expressed in plants to the endoplasmic reticulum and enable the retention of the proteins in the endoplasmic reticulum so as to accomplish glycosylation which is necessarily required for antigen activity.; The present invention also relates to a method for the mass production of hemagglutinin proteins of the antigenic H5N1 virus from the transgenic plants, and to a vaccine composition for the avian influenza virus comprising the transgenic plants or the hemagglutinin proteins produced from the plants. The method for producing hemagglutinin proteins of the H5N1 virus using transgenic plants according to the present invention enables the mass production of hemagglutinin proteins at a low cost. The plant transformation recombinant vector used in the present invention has a cellulose-binding domain inserted therein to separate proteins expressed in plants in a quick and easy manner. In addition, transgenic plants according to the present invention can be taken in the form of feed additives or the like, and therefore can be used as edible vaccines.; Further, antigenic hemagglutinin proteins produced by the method induce immune response when administered to an animal model, and therefore can be used not only as protein vaccines for the H5N1 avian influenza virus, but also as diagnostic reagents for avian influenza virus infection.