anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a health-care food of a bee glue and wood frog lecithin capsule, which comprises the following components in parts by mass: 100 parts of bee glue powder with the purity greater than 90 w%, 100-120 parts of wood frog lecithin powder and 40-60 parts of astragalus root powder. Bee glue contains more than 200 flavonoid and terpene active substances and has the functions of lowering the blood pressure, lowering the blood sugar and lowering the blood fat. Wood frog lecithin has the functions of resisting arteriosclerosis, lowering the blood fat, resisting lipid peroxide, resisting cell senescence, resisting senile dementia, reinforcing the immunity of an organism and the like and can be widely used for treating cardiac angiopathy. Astragalus root has the effects of invigorating qi, invigorating the vital function, consolidating superficial resistance and suppressing sweating, can enhance the absorption of the effective component of the wood frog lecithin and enhances the health-care effect of the bee glue capsule comprehensively. The capsule does not contain auxiliary materials, has high content of the effective component and utilizes the waste of the wood frog lecithin, so that the cost is low. The bee glue powder can prolong the storage period of the wood frog lecithin. The combined wood frog lecithin has quick acting, and the condition that the taken wood frog oil acts after three months is changed to the condition that the taken wood frog oil acts after one month.
The invention relates to a preparation method of a preparation for treating diabetes. Diabetes is a chronic disease caused by a long-term effect of genetic factors and environmental factors. The main pathological basis of diabetes is absolute or relative insufficiency of insulin secretion in vivo and rise of blood glucose caused by reduction of cells on insulin sensitivity, and urine sugar appears to lead to fat, protein, mineral substance, water and acid-base unbalance in severity. Diabetes is an endocrine metabolic disease. The history of treating diabetes by traditional Chinese medicines is over thousand years, and the traditional Chinese medicines have outstanding contribution to treatment of diabetes. According to the preparation method provided by the invention, the effective substances for treating diabetes in traditional Chinese medicinal materials are prepared by applying a biotechnology at low temperature. As the effective substances are prepared at low temperature, the low molecular components which are easy to affect by temperature in the medicinal materials are not damaged and can be effectively extracted. The substances have outstanding contribution to treatment of diabetes. The low molecular substances can promote metabolism and immunity, so that the preparation is an innovative product of a traditional Chinese medicine preparation and has a positive effect for improving treatment of diabetes.
Older adults show decline in visual search performance, but the underlying cause remains unclear. It has been suggested that older adults' altered performance may be related to reduced spatial attention to peripheral visual information compared with younger adults. In this study, 18 younger (M = 21.6 years) and 16 older (M = 69.1 years) participants performed pop-out and serial visual search tasks with variously sized gaze-contingent artificial central scotomas (3°, 5°, or 7° diameter). By occluding central vision, we measured how attention to the periphery was contributing to the search performance. We also tested the effect of target eccentricity on search times and eye movements. We hypothesized that, if attention is reduced primarily in the periphery in older adults, we would observe longer search times for more eccentric targets and with central occlusion. During the pop-out search, older adults showed a steeper decline in search performance with increasing eccentricity and central scotoma size compared with younger adults. In contrast, during the serial search, older adults had longer search times than younger adults overall, independent of target eccentricity and scotoma size. Longer search times were attributed to higher cost-per-item slopes, indicating increased difficulty in simultaneously processing complex symbols made up of separable features in aging, possibly stemming from challenges in spatially binding individual features. Altogether, our findings point to fewer attentional resources of simultaneous visual processing to distribute over space or separable features of objects, consistent with decreased dorsal visual stream functioning in aging.
Everyone aged 65 years or over, who visits the GP practice will be screened for AF with the MyDiagnostick. When the device indicates a positive result, the single lead ECG will be assessed to confirm/reject the diagnosis. Every new case of diagnosed AF will be evaluated for further treatment by the general practitioner.
BACKGROUND: Recent developments in surgical devices, including left atrial appendage closure, have enabled surgeons to perform aggressive operations for atrial fibrillation (AF). However, the outcomes of AF surgery in emergent cases have not been extensively studied.
OBJECTIVE AND METHODS: The present study aimed to investigate the effectiveness of AF surgery in emergency surgery cases associated with cardiovascular events. We enrolled 18 patients who underwent various types of AF surgery due to emergencies, including acute aortic dissection (n = 6), acute myocardial infarction (n = 5), bleeding due to perforation from radiofrequency catheter ablation (n = 4), acute mitral regurgitation (n = 2), and cardiac tumor (n = 1). Four and ten patients underwent the full maze procedure and pulmonary vein isolation, respectively. Ganglionated plexi ablation was also performed in three patients as part of a combined procedure. The left atrial appendage was solely closed in four patients.
RESULTS: There was no surgical mortality or major adverse cardiac and cerebrovascular events in our patient series. The rates of freedom of recurrence of AF or atrial tachycardia at 1 and 3 years were 92.9% and 82.5%, respectively. After a mean follow-up period of 46.7 ± 25.8 months, no thromboembolism events were observed in the patients. Furthermore, no cardiovascular death was recorded.
CONCLUSION: The surgical procedures for AF are safe and effective in cases requiring emergency surgery.
Provided herein are compositions and methods for eliciting an immune response against . The compositions and methods relate to polypeptides and fragments and variants thereof and the corresponding polynucleotides which are useful in the diagnosis, prevention and therapy of infections (e.g. periodontitis). Antibodies against the polypeptides and compositions and methods including these antibodies are also disclosed. The disclosure also describes methods for the detection, prevention and treatment of infection (e.g. periodontitis).
PURPOSE: The optimal choice of distal locking modes remains a subject due to limited available data, and therefore, this study aims to investigate the relationship between distal locking mode and postoperative mechanical complications in an intertrochanteric fracture (ITF) population who underwent closed reduction and intramedullary fixation with a PFNA-II.
METHODS: Patients aged 65 years or older who underwent surgery with PFNA-II fixation in a university teaching hospital between January 2020 and December 2021 were potentially eligible. Based on the distal locking mode, patients were classified into static, dynamic, and limited dynamic groups, among which the differences were tested using univariate analysis. Multivariate logistic regression was used to examine whether the distal locking mode was independently associated with the risk of postoperative one year mechanical complications, adjusting for covariates and potential confounders. Subgroup analyses were performed to evaluate the robustness of the findings.
RESULT: Among 507 eligible patients, 33 (6.5%) developed postoperative mechanical complications. In the univariate analysis, sex (P = 0.007), fracture type (P = 0.020), LAT Parker ratio (P = 0.023), and lateral femoral (P = 0.003) wall showed that the differences were significant. Compared to the static group, the limited dynamic group and the dynamic group showed higher odds of postoperative mechanical complications (OR = 3.314, 95% CI: 1.215-9.041; and OR = 3.652, 95% CI: 1.451-9.191, respectively). These associations were robust across a series of analyses, including adjusting for confounders and subgroup analyses.
CONCLUSION: Using a distal non-static locking mode significantly increases the risk of postoperative mechanical complications, and static locking could be a preferable option when treating an intertrochanteric fracture.
The invention relates to an aspirin enteric-coated tablet with low salicylic acid and a preparation method thereof. Specifically, the aspirin enteric-coated tablet of the invention consists of a tablet core, an isolation coating layer and an enteric coating layer. Wherein the core comprises aspirin or a salt thereof as an active ingredient and a filler; the isolating coating layer comprises an enteric material, a plasticizer and an anti-sticking agent; the enteric coating layer comprises an enteric material, a plasticizer and an anti-sticking agent. The invention adopts powder mixing and direct tabletting and adopts the coating layer, thereby avoiding the degradation reaction of aspirin after meeting water and greatly reducing the salicylic acid content of the aspirin enteric-coated tablet in the production and storage processes. The enteric-coated tablet has the advantages of no release in acid, basically complete release in buffer solution and the like, and has better quality compared with the existing preparation. The invention provides an improved preparation process, and the preparation method is simple, convenient and feasible and is easy for industrial production.
Glesatinib is an orally administered multi-targeted tyrosine kinase inhibitor (TKI) that primarily targets the Axl and Mesenchymal-Epithelial Transition (MET) receptors. Sitravatinib is an orally-available, potent small molecule inhibitor of a closely related spectrum of receptor tyrosine kinases (RTKs) including MET, Axl, MERTK, VEGFR family, PDGFR family, KIT, FLT3, Trk family, RET, DDR2 and selected Eph family members. Mocetinostat is an orally administered histone deacetylase (HDAC) inhibitor. Nivolumab is a human IgG monoclonal antibody that binds to the programmed cell death-1(PD-1) receptor and blocks its interaction with programmed cell death ligand-1 (PD-L1) and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response including anti-tumor immune response. Combining an immunotherapeutic PD-L1 checkpoint inhibitor with an agent that has both immune modulatory and antitumor properties could enhance the antitumor efficacy observed with either agent alone.

The study will begin with a lead-in dose escalation evaluation of two dose levels of each investigational agent in combination with nivolumab. Following completion of the lead-in dose escalation, enrollment into the Phase 2 study will proceed.
BACKGROUND: Obesity is a worldwide public health problem associated with cognitive and mental health problems in both humans and rats. Studies assessing the effect of fiber supplementation on behavioral deficits and oxidative stress caused by high-fat diet (HFD) consumption in female rats are still scarce. We hypothesized that HFD consumption would lead to anxiety-related behavior and hepatic oxidative stress and that inulin would protect against these changes. We analyzed the impact of HFD-induced obesity combined with fiber supplementation (inulin) on anxiety-related defensive behavior and hepatic oxidative stress.
RESULTS: Female rats were fed a high-fat diet (HFD; 45%) for nine weeks to induce obesity. The administration of inulin was found to decrease the adiposity index in both the control and obese groups. The consumption of a HFD combined with inulin supplementation resulted in a reduction in both CAT activity and carbonylated protein levels, leading to a shift in the hepatic redox balance. Interestingly, the behavioral data were conflicting. Specifically, animals that consumed a high-fat diet and received inulin showed signs of impaired learning and memory caused by obesity. The HFD did not impact anxiety-related behaviors in the female rats. However, inulin appears to have an anxiolytic effect, in the ETM, when associated with the HFD. On the other hand, inulin appears to have affected the locomotor activity in the HFD in both open field and light-dark box.
CONCLUSION: Our results show that consumption of a HFD induced obesity in female rats, similar to males. However, HFD consumption did not cause a consistent increase in anxiety-related behaviors in female Wistar rats. Treatment with inulin at the dosage used did not exert consistent changes on the behavior of the animals, but attenuated the abdominal WAT expansion and the hepatic redox imbalance elicited by high-fat diet-induced obesity.
INTRODUCTION: "Subureteric Teflon INGection" (STING) of polytetrafluoroethylene (PTFE/polytef) paste to treat vesicoureteral reflux (VUR) in children was popularised in 1984. It was later abandoned as an implantation material because of the possibility of migration from the injection site. Giant-cell foreign-body granuloma to Polytef in the bladder is a rare cause of ureteric obstruction. Only a handful of cases have been reported in the literature.
METHODS: We performed a prospective analysis of a series of 6 adult patients who had childhood STING and presented with foreign-body granuloma to Polytef in the bladder. We report their clinical presentation, findings and treatment.
RESULTS: 1 male and 5 females with a history of STING procedure in childhood for VUR presented in later life with foreign-body granuloma to Polytef. The median age at first STING procedure and at presentation to the Urology Department was 3 and 34 years respectively. The most common clinical presentations were flank pain and urinary tract infection (UTI) and all patients had radiological findings of calcified lesions at the vesicoureteric junction(s). 4 patients had histological findings of giant-cell foreign-body granuloma. 4 patients required definitive ureteric reimplantation.
CONCLUSION: Polytef granuloma causing distal ureteric obstruction may give rise to significant morbidity and renal damage. Due to the likelihood of progression of the granuloma, excision and ureteric reimplantation is considered the standard approach in the management of patients with viable kidneys.
LEVEL OF EVIDENCE: Level 5.
BACKGROUND: Fibromyalgia is a common condition characterised by chronic widespread musculoskeletal pain and central sensitivity features. Appropriate management requires a multidisciplinary approach prioritising non-pharmacological strategies. Evidence-based fibromyalgia medications are not always easily available, effective or tolerated.
AIM: To characterise actual medication usage in Australian fibromyalgia patients.
METHODS: Demographic and clinical data, including medication use information, were gathered by chart review from patients attending the Monash Fibromyalgia Clinic between January 2019 and June 2022. Eligible patients were invited to complete an anonymous questionnaire between June and August 2022 to assess current therapeutic use. The questionnaire assessed fibromyalgia clinical features by using the Revised Fibromyalgia Impact Questionnaire and the 2016 modified American College of Rheumatology Fibromyalgia criteria.
RESULTS: The chart review included 474 patients, and 108 participants completed the questionnaire. Most chart review (78.7%) and questionnaire participants (85.2%) reported using at least one medication for their fibromyalgia. 48.5% of chart review patients and 58.3% of questionnaire participants reported using at least one evidence-based medication, usually amitriptyline, duloxetine or pregabalin. However, the most common individual medications for questionnaire participants were non-steroidal anti-inflammatory drugs (48.2%), paracetamol (59.3%) and opioids (34.3%), with most opioids being typical opioids. Among questionnaire participants, 14.8% reported using cannabinoids, and 70.4% reported using at least one supplement, vitamin or herbal/naturopathic preparation. Not all medication or substance use was recorded during clinic appointments.
CONCLUSION: Fibromyalgia patients engage in various pharmacotherapeutic strategies that are not always evidence-based or disclosed to their treating clinicians.
A method for treating or preventing the diseases of periodontal tissues in the children living in the xenobiotic-contaminated areas comprises the measures for prophylaxis and the use of medicinal products. The oral bath containing 15 % aqueous antiseptic solution is provided 3-4 times a day for 10 days. The composition of antiseptic solution is such as follows: the flowers of chamomile – , the bark of the oak – , the leaves of the sage – , the herb of the arnica – , the rhizomes of the sweet flag – , the herb of the peppermint – , the herb of the thyme – . 10 mL of the composition is diluted in 50 mL of water (previously boiled). In one hour after the oral bath, the combined drug containing Lysozyme and Dequalinium chloride is taken for sucking. Starting from the first day, the sorbent hydrogel of methyl silicic acid is provided at a dose of thrice a day in 1.5-2 hours prior to meals. The sorbent should be kept in the oral cavity for a time. The maintenance therapy is also provided for 30 days using multivitamin complex in a form of a gel containing (per ) retinol palmitate – 2.75 mg, thiamine hydrochloride – 0.33 mg, riboflavin – 0.33 mg, nicotine amide – 5 mg, pyridoxine hydrochloride – 1.5 mg, cyancobalamine – 1 µg, ascorbic acid – 100 mg, calcium pantothenate – 1 mg, cholecalcipherol – 600 IU, alpha-tocopherol acetate – 1.65 mg, manganese (II) hydrocitrate soluble – 6 mg, sodium molybdate – 0.25 mg, calcium phosphinate – 2.5 mg, lecithin – 200 mg. The combined calcium and vitamin Dcomposition is also provided (1250 mg of calcium carbonate and 200 mg of cholecalcipherol).
Patients with low risk NPC( Stage III-IVa, except T4N2/AnyTN3, AJCC 8th and EBV DNA \<4000 copies/ml) are randomly assigned to receive CCRT alone or induction chemotherapy plus CCRT. Patients in both groups receive cisplatin 100 mg/m² every 3 weeks for 3 cycles, concurrently with intensity-modulated radiotherapy (IMRT). IMRT is given as 2.12 Gy per fraction with five daily fractions per week to a total dose of 70 Gy. The induction chemotherapy plus CCRT group receive gemcitabine (1000 mg/m² d1,8) and cisplatin (80mg/m² d1) every 3 weeks for three cycles before CCRT. Our primary endpoint is progress-free survival. Secondary end points include overall survival (OS), Locoregional progression, Distant progression and toxic effects. All efficacy analyses are conducted in the intention-to-treat population, and the safety population include only patients who receive their randomly assigned treatment.
INTRODUCTION: Minimally invasive ventral mesh rectopexy is considered the standard of care in the surgical management of rectal prolapse syndromes in fit patients. We aimed to investigate the outcomes after robotic ventral mesh rectopexy (RVR) and compare them with our laparoscopic series (LVR). Additionally, we report the learning curve of RVR. As the financial aspect for the use of a robotic platform remains an important obstacle to allow generalized adoption, cost-effectiveness was also evaluated.
PATIENTS AND METHODS: A prospectively maintained data set including 149 consecutive patients who underwent a minimally invasive ventral rectopexy between December 2015 and April 2021 was reviewed. The results after a median follow-up of 32 months were analyzed. Additionally, a thorough assessment of the economic aspect was performed.
RESULTS: On a total of 149 consecutive patients 72 underwent a LVR and 77 underwent a RVR. Median operative time was comparable for both groups (98 min (RVR) vs. 89 min (LVR); p = 0.16). Learning curve showed that an experienced colorectal surgeon required approximately 22 cases in stabilizing the operative time for RVR. Overall functional results were similar in both groups. There were no conversions or mortality. There was, however, a significant difference (p < 0.01) in hospital stay in favor of the robotic group (1 day vs. 2 days). The overall cost of RVR was higher than LVR.
CONCLUSIONS: This retrospective study shows that RVR is a safe and feasible alternative for LVR. With specific adjustments in surgical technique and robotic materials, we developed a cost-effective way of performing RVR.
The utility model discloses a clean system of operating room relates to medical field. The method aims to overcome the defects that the existing operation has low turnover rate, the cleaning process of an operation room after an operation is complicated, and a cleaning worker cannot well supervise the operation room, so that the operation room is not clean or the self-cleaning time is short, and a new operation is started. The utility model provides a clean system of operating room, include: the system comprises a processor, one or more than one first control panel, a second control panel and display screens with the same number as the first control panel. The utility model discloses an thereby identification system on first control panel and the second control panel discerns medical staff, the personnel's identity of keeping a public place clean authorizes, reads HIS system information production postoperative operation room cleanness requirement and timing warning etc. through the treater. The utility model relates to a clean system of operating room can improve operation turnover rate, reduces medical staff's work load, and accurate discernment personnel authorize, reduces the emergence of error accident.
Early detection of nonconvulsive status epilepticus (NCSE) in patients treated in neurological intensive care unit (NICU) is essential, as delayed treatment can aggravate their clinical situation and worsen the outcome. In this study in intensive care patients with severe brain injury due to malignant middle cerebral artery (MCA) infarction, subarachnoidal hemorrhage (SAH) or intracerebral hemorrhage (ICH) with suspected status epilepticus in the surface EEG the hybrid catheter Dialytrode will be implanted in the cortical brain tissue by neurosurgeons for short time continuous bedside multimodal neuro-monitoring. Dialytrode combines a microdialysis catheter and depth EEG probe. Ten subjects will be monitored by Dialytrode and an additional (intracranial pressure (ICP) probe. Subjects with an clinical indication of an external ventricular drain (EVD) or cerebral microdialysis alone serve as control. The monitoring period with the device is limited to the microdialysis phase with a maximum of 28 days. Subjects will be followed up for 7 days after end of intracerebral monitoring.