anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A substance containing sulphur in a chemically active condition is made by mixing bentonite with selenium sulphide, for example in equal parts, heating, for example, to a temperature of approximately 125-150 DEG  C., until the selenium sulphide is fused, cooling the mass and converting it to a powder.  For use the powder may be suspended in water to a consistency varying from a paste to a colloidal suspension.  Specification 351,188 is referred to.  The Specification as open to inspection under Sect. 91 (3) (a) comprises also the use of any combination of selenium and sulphur and hydrophilic substances such as fuller's earth and silica gel. This subject-matter does not appear in the Specification as accepted.ALSO:A substance containing sulphur in a chemically active condition is made by mixing bentonite with selenium sulphide, for example in equal parts, heating, for example to a temperature of approximately 125 DEG  to 150 DEG  C., until the selenium sulphide is fused, cooling the mass and converting it to a powder.  The product may be used, with or without accelerators, as a vulcanizing agent for rubber.  Specification 351,188 is referred to.  The Specification as open to inspection under Sect. 91 (3) (a) comprises also the use of any combination of selenium and sulphur and hydrophilic substances such as fuller's earth and silica gel. This subject-matter does not appear in the Specification as accepted.ALSO:A substance containing sulphur in a chemically active condition is made by mixing bentonite with selenium sulphide, for example in equal parts, heating for example to a temperature of approximately 125-150 DEG  C., until the selenium sulphide is fused, cooling the mass and converting it to a powder.  For use the powder may be suspended in water to a consistency varying from a paste to a colloidal suspension.  The paste may be used as a therapeutic agent in the treatment of skin diseases such as eczema, or as a skin cream for protection against, for example, mercury.  Aqueous dispersions may be used as fungicides and the substance may also be used, with or without accelerators, as a p  vulcanizing agent for rubber.  Specification 351,188 is referred to.  The Specification as open to inspection under Sect. 91 (3) (a) comprises also the use of say combination of selenium and sulphur and hydrophilic substances such as fuller's earth and silica gel. This subject-matter does not appear in the Specification as accepted.
PROBLEM TO BE SOLVED: To obtain the subject extract not having a problem on color, smell and safety, giving effects for improving skin roughness, improving keratin, beautifying skins, restroring hair, etc., and useful as a medicine for treating heart diseases, reciprocatory organ diseases, central nervous system diseases, etc., by subjecting the body of a labiate: Coleus forskolhii Brig., to a supercritical extraction method. SOLUTION: This forskolin-containing extract is obtained by subjecting the whole body or root portions of a labiate: Coleus forskolhii Brig., to a supercritical extraction method using a supercritical fluid. The extract is preferably obtained by subjecting the labiate: Coleus forskolhii Brig. to a supercritical extraction method using carbon dioxide as a supercritical fluid at a pressure of 73-200 kg/cm<2> , removing the first extract and again subjecting the residue to the supercritical extraction method using carbon dioxide at a pressure 200-500 kg/cm<2> . A solvent for assisting the extraction is an organic solvent (preferably ethanol). In the supercritical extraction method, the plant is heated at the critical temperature of the supercritical fluid or higher, preferably at 40-100 deg.C. The extract is administered at a daily dose of 0.1-10 mg (as forskolin) per adult.
The Non-group dance intervention is designed to capture the same dance movement and auditory stimuli as the group class without social interaction. Recordings of the dance instructor teaching a dance class will be played. This will ensure participants hear comparable music and receive comparable verbal auditory cues to prompt dance movements that students in the group class will hear, without interacting with other people. Improvisational dance is particularly suited for this means of delivery because the primary method of instruction is verbal auditory cueing. Participants will be asked to follow the same schedule as participants in the Dance Group arm and complete 2 one-hour dance sessions each week.
All participants will complete two measures of social harm at monthly research appointments for a three month period. The social harms assessments will be (1) the ACASI-SHQ that was developed in Phase 1 and (2) the HIV Vaccine Trials Network (HVTN) Social Impact Assessment.
In surgical group, coverage with a bipedicled palmar island flap will be performed ambulatory, either on admission if patients are directly oriented to the Hand Surgery department, or within 48h of initial visit for patients addressed from the Emergency department. The flap group will be evaluated on admission, at 48h, and 6 weeks.
A total 10 acupoints of bilateral PC6, PC5, SP3, KI3, and ST36 will be chosen for the intervention group, also known as the acupuncture group. The depth of acupuncture will be varied by participant by participant. After acupuncture needles be inserted, the needles will be manually manipulated to obtain pre-determined sensation, the De Qi. Then, acupuncture will remain inserted for 20 minutes.
In this case report, we present the unique and intriguing case of a 57-year-old man who experienced exertional palpitations and shortness of breath for 5 years. He was diagnosed with idiopathic heart failure three years ago, leading to diuretic treatment. Physical examination revealed notable left lower extremity swelling, severe varicose veins, and cardiac murmurs. Echocardiography showed significant cardiac enlargement and severe functional mitral and tricuspid valve regurgitation. Computed tomography (CT) imaging uncovered a 10 mm left common iliac arteriovenous fistula, causing abnormal early filling of the inferior vena cava (IVC) and marked IVC dilation. Open surgical repair of the arteriovenous fistula resulted in symptom relief and improved cardiac function. This case underscores the importance of considering unusual causes in heart failure patients and highlights the value of early diagnosis and intervention in complex cardiac-vascular interactions.
1. Technical Result Increase in efficiency of treatment of diseases caused by angiotensin and endothelin receptors.           2. Essence A compound is presented by a structural formula wherein R1, R2 and R3 have the values indicated in the specification; the mentioned compounds are used for treatment of endothelin-dependent and angiotensin-dependent diseases and conditions such as hypertension; methods for their production, and pharmaceutical compositions containing such compounds.         3. Field of Application Medicine.                Tabl.: 3
This group will receive Abdominal KT tape (From initial 4 h to 72 h of menstruation). General physio session will also be given to this group.
OBJECTIVES: Researchers suggested that the interruptive effects of chronic pain on cognitive functions may be modulated by the level of pain catastrophizing (PC). However, in individuals with chronic low back pain (CLBP), domains of cognitive function that may be affected by the level of PC remain largely unclear. Therefore, this study aimed to compare cognitive functions between individuals with CLBP with high and low PC and pain-free controls.
MATERIALS AND METHODS: This cross-sectional study examined cognitive functions of 42 individuals with CLBP and 21 pain-free controls. The PC scale was used to stratify participants with CLBP into high and low PC. Participants performed 5 cognitive tests from the Cambridge Neuropsychological Test Automated Battery, namely 5-choice reaction time, rapid visual processing, spatial working memory, attention switching task, and stop signal task.
RESULTS: The statistical analyses revealed that compared with individuals with CLBP with low PC and pain-free controls, individuals with high PC demonstrated greater values of the between errors ( P =0.01), reaction latency ( P <0.001), and stop signal reaction time variables ( P =0.004, 0.003, respectively) but lower values of probability of hit ( P =0.02, 0.01, respectively), A' ( P =0.01, <0.001, respectively), and percent correct trials variables ( P =0.002, <0.001, respectively).
DISCUSSION: The results of the current study showed deficits in sustained attention, working memory, cognitive flexibility, and inhibitory control in individuals with CLBP with high PC. From a clinical perspective, therapeutic interventions targeting PC should be considered to decrease catastrophic thinking about pain in individuals with CLBP. Additional research is warranted to explore cognitive functioning as an outcome of these interventions in individuals with CLBP.
PURPOSE:To obtain a higher aliphatic alcohol preparation containing higher aliphatic alcohol, tocopherol and trigriceride, having good absorption and capable of exhibiting sufficient physiological activity by a small amount of administration. CONSTITUTION:This preparation contains 0.0001-2wt.% 22-38C higher aliphatic alcohol (e.g. octacosanol), 0.0001-10wt.% tocopherol and 88-99.99wt.% trigriceride as essential ingredients. The preparation allows the higher aliphatic alcohol to coexist with tocopherol and keeps so as to dissolve these compounds in trigriceride. Although the preparation is generally used as a food, the preparation is useful also as a medicine. The higher aliphatic alcohol preparation has low viscosity of when dissolved as a solution, suitable for administration, can quickly absorb a large amount of higher aliphatic alcohols and is rapidly metabolied and readily emulsifiable and blendable.
In the diagnosis of migraine, which is a neurovascular disease, gadolinium-based contrast agents (GBCAs) are used to rule out more serious conditions. On the other hand, it remains unclear as a scientific gap whether GBCAs may trigger migraine-related pain. The aim of this study was to investigate the effect of GBCAs on mechanical and thermal pain behaviour in a nitroglycerin (NTG)-induced migraine model in mice. NTG (10 mg/kg) was administered intraperitoneally to adult (6-8weeks old) BALB/c mice 2 h before behavioral tests 5 times every other day on days 1st, 3rd, 5th and 9th to induce migraine model (N = 50). As GBCAs, gadobenate dimeglumine (linear-ionic), Gadodiamide (linear-nonionic), and gadobutrol (macrocyclic-nonionic) were delivered intravenously through the tail vein of mice for 5 days on test days. Mechanical pain threshold (plantar and facial withdrawal threshold) was evaluated by plantar von Frey and periorbital von Frey tests on days 1st, 5th, and 9th, and thermal pain threshold (latency) was evaluated by hot plate and cold plate tests on days 3rd and 7th. There was a statistically significant increase in mechanical and thermal hyperalgesia in NTG administered groups compared to the control group. Gadodiamide, gadobutrol and gadobenate dimeglumine administration significantly decreased latency, paw and facial withdrawal threshold (0.18 ± 0.05, 0.17 ± 0.07, 0.16 ± 0.09; 9th day values respectively) compared to NTG group (0.27 ± 0.05). The results of this in vivo study show that GBCAs produce effects that may trigger migraine attacks in migraine. It is recommended that these effects be further investigated and supported by further clinical studies.
Objective: To investigate the association between psoas muscle mass (PMM) and failure of ureteral access sheath (UAS) insertion and complications from retrograde intrarenal surgery (RIRS). Materials and Methods: A multicenter retrospective case-control study was conducted that included patients who underwent RIRS despite failure of UAS insertion (Cohort 1) and confounder-matched control patients who underwent RIRS after successful UAS insertion (Cohort 2). For morphometric analysis of PMM, ipsilateral psoas muscle areas (iPMAs) were measured using the coreslicer.com webkit. After comparing demographic, clinical, and complication rates and iPMAs between cohorts, gender-specific median iPMAs were also determined to further subdivide patients in each cohort as either low iPMAs or high iPMAs. Thereafter, patients were also compared in terms of RIRS complications. Results: Cohort 1 included 86 patients whereas Cohort 2 consisted of 124 matched cases. The median (interquartile range) iPMAs were similar between the cohorts: Cohort 1, 11.05 (6.82-14.44) cm2 versus 11.12 (6.97-13.69) cm2 for Cohort 2 (P ˃ .05). There was a significant inverse relationship between iPMAs with age (r = -0.222) and Charlson comorbidity index (r = -0.180) for all patients (P ˂ .05). Perioperative and postoperative complication rates were 8.1% and 16.3% for Cohort 1 and 6.5% and 21% for Cohort 2, respectively. The complication rates were not statistically different between patients with high iPMAs and those with low iPMAs, in male or female patients (P > .05). Conclusions: These results show that failure of UAS was not associated with PMM. Furthermore, since the complication rates were similar between patients with high PMM and low PMM, RIRS may be a reliable treatment choice for sarcopenic patients as well as in nonsarcopenic patients.
The trial is designed to help us to choose the maintain treatment regiment for the patients with effective first-line salvage therapy. After inorelbine and gemcitabine (NG) or vinorelbine and platinum (NP) regiments for 6 cycles, patients will be assess the effect of treatment. As for the patients with complete response (CR), partly response (PR) and stable disease(SD), the investigators will randomly assign them to receive 3 cycles of original regiment, or 6 cycles of vinorelbine, or 6 cycles of capecitabine. Trasuzumab will be used to patients if HER-2 positive. Endocrine therapy will be used if the hormone receptors positive after the chemotherapy. The effectiveness of therapy will be estimated after the maintain therapy. The first two years the patient was prescribed every 3 months to review the disease, then review the disease every six months. The primary endpoint is to assess disease-free survival (DFS), the secondary endpoint is to assess the overall survival (OS).
The procedure commences with local disinfection and anesthesia, followed by a percutaneous right femoral artery puncture, performed using a modified Seldinger technique. A 5-F Simmons Ⅰ catheter was introduced through a vascular sheath and positioned in the common hepatic artery with the guidance of digital subtraction angiography to identify the tumor-supplying vessels. A 2.8-F microcatheter catheter was advanced into the vessel supplying the hepatic tumor. In cases of bilobar disease, the initial treatment focus was on the lobe with the greatest tumor burden, with the contralateral lobe addressed in a subsequent TACE session scheduled 4-6 weeks apart. In the standard TACE protocol ( hepaspheres are loaded with Irinotecan at 50 mg for colon metastases and Idarubicin at 10 mg for breast metastases), Bevacizumab 50 mg-loaded hepaspheres was added. The procedure was monitored under fluoroscopy until arterial flow stasis was achieved.
The present invention provides for the novel method for the inhibition of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (Apo B) secretion having Formulas I-XI in lowering serum lipids and in the prevention and treatment of related disease. Regulation of the VLDL/LDL pathway as a therapeutic means to reduce hyperlipidemia is supported from studies in liver cells and in an animal model. Accordingly, the inhibition of regulation described herein is identified as a new therapeutic target for treatment of cardiovascular disease or diseases associated with cardiovascular disease such as hyperlipidemia. Treatment of cardiovascular disease and associated conditions or diseases with the novel TTP inhibitors of the invention reduces MTP protein associated lipid production without side effects that occur with other methods of MTP protein associated lipid inhibition. We describe small molecules (disubstituted tetrahydro-tetrazolo(l,5a)pyrimidine (TTP) and a method of their use to inhibit the secretion of ApoB and LDLs from liver derived cells in tissue culture and in animal models. We further describe how to use these small molecules in the management of diseases associated with elevations of circulating LDLs.
This study assessed whether symptoms of muscle damage could be reduced by a combination of therapeutic ultrasound and electrical stimulations, and whether this could be enhanced by blood flow restriction. Before and 48 h after performing eccentric elbow flexion exercises, individuals completed assessments of muscle damage. A 10-min therapeutic ultrasound and electrical stimulation treatment was then applied with and without blood flow restriction to assess short (5 min) and long-term (24 h) improvements. Twenty-three individuals completed the study (11 females). Data were analysed using Bayesian repeated measures ANOVAs. The damaging exercise increased discomfort (BF10 = 2.93e14) and relaxed joint angle (BF10 = 2425.90) while decreasing pain pressure threshold (BF10 = 289.71). Each of these variables was acutely improved with the combination treatment protocol (all BF10 ≥ 74) with no added effect of blood flow restriction. A combination of therapeutic ultrasound and interferential electrical stimulations appeared effective at acutely alleviating symptoms of muscle damage with no additive effect of blood flow restriction.
ORA-BLEND SF® (sugar-free flavoured suspending vehicle). Final volume in the oral syringe will be 9 mL.
The anterior thalamic nuclei are important for cognition, and memory in particular. However, little is known about how the anterior thalamic nuclei are affected in many neurological disorders partly due to difficulties in selective segmentation in in vivo scans, due to their size and location. Post-mortem studies, therefore, remain a valuable source of information about the status of the anterior thalamic nuclei. We used post-mortem tissue to assess the status of the anteroventral thalamic nucleus in Down syndrome using samples from males and females ranging from 22-65 years in age and comparing to tissue from age matched controls. As expected, there was increased beta-amyloid plaque expression in the Down syndrome group. While there was a significant increase in neuronal density in the Down syndrome group, the values showed more variation consistent with a heterogeneous population. The surface area of the anteroventral thalamic nucleus was smaller in the Down syndrome group suggesting the increased neuronal density was due to greater neuronal packing but likely fewer overall neurons. There was a marked reduction in the proportion of neurons immunoreactive for the calcium-binding proteins calbindin, calretinin, and parvalbumin in individuals with Down syndrome. These findings highlight the vulnerability of calcium-binding proteins in the anteroventral nucleus in Down syndrome, which could both be driven by, and exacerbate, Alzheimer-related pathology in this region.
Mouth-wash powders comprise a stabilized oxygen-yielding compound admixed with a silver-containing compound, and preferably also with an acid substance.  The powders are mixed with water for use and yield free oxygen and free silver in the mouth.  The oxygen-yielding compound, such as urea-hydrogen peroxide, alkali peroxide-pyrophosphate, alkali perborate or alkali percarbonate is preferably free from water of crystallization and is stabilized in known manner, for example with magnesium silicate.  The silver compound may be an inorganic salt such as the nitrate or sulphate or the silver chloride-ammonia compound, or an organic salt such as the acetate, benzoate, salicylate, or p-hydroxybenzoate. Acids such as citric, tartaric, boric or phosphoric or acid compounds such as acid phosphates are employed preferably in such proportion as to neutralize only 40 to 60 per cent of the alkalinity of the oxygen-yielding compound.  Flavourings or perfumes may also be added. According to an example, 30 gms. of dehydrated sodium perborate are mixed with 1,6 grms. of the silver salt of p-hydroxybenzoic acid and 11,25 gms. of tartaric acid.
The emerging model of obesity and diabetes is characterised by sub-acute chronic inflammation and insulin resistance. Mechanistic data indicates inflamed adipose tissue with increased infiltration of immune cells that generate pro-inflammatory cytokines. With childhood obesity in Ireland increasing at a rapid pace, it is important to establish the role of a non-pharmacological dietary approach to decreasing the sub-acute chronic inflammation seen in overweight and obese children. Several foods contain nutrients that are known to have anti-inflammatory properties. Such foods including fish, fruits and vegetables are known to be deplete in the adolescent diet. The aim of this project is to investigate whether a nutritional supplement containing anti-inflammatory nutrients, n-3 polyunsaturated fatty acids (found in fish oil), vitamin C, vitamin E, and polyphenols found in green tea and tomato; will improve metabolic phenotype in 13-18 year old teenagers over an 8-week period. Further, to provide insight into the role of genetics in the development of metabolic dysregulation and response to dietary treatment.