anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a preventive agent little causing environmental pollution with hardly affecting bad effects to salmons and trout.  <P>SOLUTION: The agent for preventing Ichtyobodo of salmons and trout contains a tea extract. The method for preventing Ichtyobodo of salmons and trout includes a process for preventing Ichtyobodo, a parasite of salmons and trout, by using the preventive agent. The tea extract is used to suppress or inhibit growth of Ichtyobodo, the parasite of salmons and trout. The tea extract is also used for preventing and treating parasitic diseases of salmons and trout caused by Ichtyobodo.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The invention relates to medicine and is directed at developing means and methods for narcological practice and for preventive measures in order to reduce the risk of falling sick with such menacing modem diseases like dependence diseases, in particular alcoholism, narcomania and toximania. Said invention provides for using already known chemical compounds, i.e. vicinal dithioglycols for developing medical agents exhibiting properties for preventing contraction or development or reducing the speed of pathological processes forming a base for dependence diseases, in particular withdrawal syndromes. The inventive substances reduce or block pharmacological effects resulting from ethanol injection and/or narcotics, thereby directly influencing pathogenic mechanisms of the dependence diseases, in particular alcoholism. It is stated that said agents are particularly efficient when they are perorally administered. Said invention is accompanied by experimental material which proves the large perspective of the inventive agents and of a prophylactic method which provides for the use thereof before and after consuming alcohol-containing beverages or narcotics. The use of the invention makes it possible to reduce the degree of falling sick with alcoholism and narcomania and to reduce the toxic action of alcohols during the household use thereof.
BACKGROUND: Uveal melanoma (UM) is the most common primary ocular tumour in adults. The most used eye-preserving treatments are charged-particle therapy (CPT) and brachytherapy. We performed a systematic review and meta-analysis to compare efficacies and complications of these two radiotherapies.
METHODS: We searched EMBASE, PubMed, MEDLINE, and the Cochrane Library from January 2012 to December 2022. Two independent reviewers identified controlled studies comparing outcomes of CPT versus brachytherapy. Case series that utilize either treatment modality were also reviewed.
RESULTS: One hundred fifty studies met the eligibility criteria, including 2 randomized control trials, 5 controlled cohort studies, and 143 case series studies. We found significant reduction in local recurrence rate among patients treated with CPT compared to brachytherapy (Odds ratio[OR] 0.38, 95% Confidence interval [CI] 0.24-0.60, p < 0.01). Analysis also showed a trend of increased risks of secondary glaucoma after CPT. No statistically significant differences were found in analyzing risks of mortality, enucleation, and cataract.
CONCLUSIONS: Our study suggested no difference in mortality, enucleation rate and cataract formation rate comparing the two treatments. Lower local recurrence rate and possibly higher secondary glaucoma incidence was noted among patients treated with CPT. Nevertheless, the overall level of evidence is limited, and further high-quality studies are necessary to provide a more definitive conclusion.
PROBLEM TO BE SOLVED: To obtain an excellent ultraviolet absorber having no thickness feeling even if being blended in a composition by using a multiple phosphate of Fe, Mn and one or more kinds of metals selected from Cr, Ce, Mg, Al, Ti, Zn, K, Ca and Na. SOLUTION: This multiple phosphate is water-insoluble or hardly soluble, and exhibits ultraviolet absorption action even in a water based carrier. As the concrete multiple phosphate, (Fe, Mn, Cr)PO4 , (Fe, Mn, Ce)PO4 and the like are exemplified. Though the multiple phosphate is produced by an ordinal phosphate producing method, a closed system liquid phase method is particularly preferable. Concretely the method for mixing an aq. solution of a Fe and a Mn water soluble salt and a solution of water soluble salts of one or more kinds of metals selected from Cr, Ce, Mg, Al, Ti, Zn and K with a solution of a water soluble phosphate such as sodium phosphate in an autoclave and drying a precipitate produced by the reaction is exemplified.
A glandular extract for subcutaneous injection in treating carcinoma, sarcoma, &c., is prepared from the isolated cortical portion of suprarenal glands by means of a solvent, such as water, which is non-irritating to normal body tissue.  The glands are separated from fat and adhering tissue, placed for 3-4 minutes in a normal saline solution, then cut from pole to pole.  The medullary portion is dissected away with the inner third of the cortex.  The remainder of the cortex with the envelope, is macerated with 2 1/2 volumes of water, and the temperature gradually raised to 85 DEG  C. and then reduced to 65 DEG  C.  The mixture is slightly acidified with hydrochloric, acetic, or other acid, allowed to cool to 55 DEG  C. and strained into 95 per cent alcohol. A further quantity of alcohol is added to precipitate colloidal and other matter and after standing at room temperature the clear liquid is decanted and filtered. Filtration is repeated at intervals, and the alcohol is then distilled off, leaving an aqueous solution which is allowed to stand and filtered.  A preservative such as thymol or tricresol may be added, and the extract bottled for storage.
The aging process is followed by metabolic and body composition changes, increasing the risk of obesity and sarcopenia. The coexistence of these conditions acts synergistically on each other and is known as sarcopenic obesity. Beige adipose tissue is a tissue type that emerges from subcutaneous white adipose tissue (WAT), altering its phenotype to resemble the thermogenic functions of brown adipose tissue (BAT) in response to beta-adrenergic stimuli. Some in vitro and animal studies suggest that taurine supplementation and physical exercise are effective interventions in stimulating the aforementioned tissue, promoting what is known as WAT darkening, improving energy metabolism and showing benefits on the maintenance of muscle mass via stimulation of the coactivating protein PGC1α. These investigations are scarce in humans and could help health professionals in the adjuvant treatment of sarcopenic obesity. Therefore, the aim of the present study is to analyze the effects of taurine supplementation associated or not with physical exercise on the darkening of the WAT in sarcopenic obese elderly women. Volunteers with low appendicular lean mass (\<15 kg) and body mass index (BMI) between 30 and 40 kg/m² will be recruited. These will be subdivided into 4 groups: control group (Cont), taurine (Tau), exercise (Exe) and exercise and taurine (Exe +Tau) and the duration of the intervention for all groups will be 16 weeks. Data related to anthropometry, body composition, biochemical tests, and food intake will be collected. To evaluate the effects on the darkening, a biopsy of the abdominal subcutaneous white adipose tissue will be performed to analyze protein, lipidomic and genetic parameters of this tissue pre and post intervention. Data will be analyzed by Analysis of Variance (ANOVA) or Kruskal-Wallis test depending on the normality of the data that will be tested by Shapiro-Wilk. A significance level for p \<0.05 will be admitted. All analyzes will be performed in SPSS version 20 software.
BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization (MR) analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC.
PATIENTS AND METHODS: We conducted a GWAS meta-analysis of 6176 EOCRC cases and 65 829 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT), the Colon Cancer Family Registry (CCFR), and the UK Biobank. We then used the EOCRC GWAS to investigate 28 modifiable risk factors using two-sample MR.
RESULTS: We found two novel risk loci for EOCRC at 1p34.1 and 4p15.33, which were not previously associated with CRC risk. We identified a deleterious coding variant (rs36053993, G396D) at polyposis-associated DNA repair gene MUTYH (odds ratio 1.80, 95% confidence interval 1.47-2.22) but show that most of the common genetic susceptibility was from noncoding signals enriched in epigenetic markers present in gastrointestinal tract cells. We identified new EOCRC-susceptibility genes, and in addition to pathways such as transforming growth factor (TGF) β, suppressor of Mothers Against Decapentaplegic (SMAD), bone morphogenetic protein (BMP) and phosphatidylinositol kinase (PI3K) signaling, our study highlights a role for insulin signaling and immune/infection-related pathways in EOCRC. In our MR analyses, we found novel evidence of probable causal associations for higher levels of body size and metabolic factors-such as body fat percentage, waist circumference, waist-to-hip ratio, basal metabolic rate, and fasting insulin-higher alcohol drinking, and lower education attainment with increased EOCRC risk.
CONCLUSIONS: Our novel findings indicate inherited susceptibility to EOCRC and suggest modifiable lifestyle and metabolic targets that could also be used to risk-stratify individuals for personalized screening strategies or other interventions.
Patients in the control group will continue to have usual scheduled outpatient follow-up visits at the hospital initiated by the physician every 3 months. These patients do not use the clinical PRO questionnaire, but complete the research questionnaires.
BACKGROUND: Exposure to excessive noise volumes is an occupational health and safety risk. Australian guidelines recommend a time weighted exposure maximum of 85 dB (dB) or a maximum peak noise level of up to 140 dB, as chronic and repeated high dB exposure can result in significant hearing impairment. The aim of this study was to assess the volume of noise generated by common surgical instruments while utilizing the National Institute for Occupational Safety and Health (NIOSH) app.
METHODS: Sound levels were measured using the NIOSH app. The NIOSH app was used to take equivalent continuous A-weighted sound levels (LAeq) and the C-weighted peak sound pressure (LCpeak) measurements for specific instruments while in use in theatre. A minimum of three readings per instrument were taken at immediate and working distances.
RESULTS: LAeq measurements ranged from 62.9 to 89.3 dB. The Padgett Dermatome and Frazier Sucker exceeded recommended exposure limits with an averaged LAeq reading of 85.7 dB(A) and 85.1 dB(A) respectively. LCpeak readings ranged from 89.9 to 114.7 dB(C) with none of the instruments exceeding a peak sound level beyond the recommended level of 140 dB(C).
CONCLUSION: The cumulative effect of loud surgical instruments across prolonged or combined operations may result in theatre staff being exposed to hazardous noise levels, impacting the health and wellbeing of staff, staff performance and patient care. Utilization of a phone app can improve the awareness of noise pollution in theatres, thereby empowering staff to be proactive about their health and improvement of their work environment.
The primary objective of the data analysis will be to measure the rate of smoking cessation in the two treatment groups. Smoking cessation will be measured weekly through a composite measure of self-reported abstinence, end expired carbon monoxide (CO) of less than C10 ppm and urine cotinine dipstick measure of \< 30 ng/ml. The primary endpoint will be point prevalence at 12 weeks. The four week continuous abstinence rate for the last four weeks of the treatment phase will also be evaluated. The point prevalence abstinence rates will also be obtained. The secondary objective is to determine whether smoking cessation is associated with a worsening of cognition and psychiatric symptomology. We hypothesize that subjects who achieve abstinence in the varenicline group will not show worsening on neurocognitive and symptom measures compared to abstinence subjects in the placebo group. Lastly, we will attempt to identify any clinical or topographic markers which predict cessation.
Described are methods for detecting and/or diagnosing systemic sympathetic nervous system dysfunction or disease in a subject. One embodiment comprises using a topical apraclonidine eye drop to detect an ocular condition indicative of sympathetic dysfunction or disease in a subject with Guillain-Barré syndrome (GBS). Embodiments can be used to detect and/or diagnose systemic sympathetic nervous system dysfunction or disease early, prior to development of substantial symptoms. Embodiments can also be used to unmask either bilateral ptosis or bilateral Horner's syndrome in GBS patients with the application of the drop to one eye. Also described are dosage forms suitable for use in the methods described herein. The dosage forms comprise an alpha receptor agonist with alpha-1 receptor activity. In one embodiment the dosage form comprises apraclonidine packaged as a single-use eye drop.
PURPOSE: To obtain a nail enamel capable of manifesting an excellent local release of active materials to a morbid part of a nail as an easily removable coating without attaching healthy nail substance. The nail enamel used for therapy of nail mycosis. CONSTITUTION: This nail enamel contains a polymeric film forming material, especially a cellulose derivative, at least one kind of antifungal material such as tioconazole, econazole, especially clotrimazole, etc., and urea, releases the antifungal material and urea from the enamel after applying to a topical part and drying. The enamel is preferably containing 5-30wt.% of the antifungal material, and 15-60wt.% of urea based on the nonvolatile component. The enamel preferably contains 5-30wt.% of softener selected from the group comprising ester of phthalic acid, glycol or ricinus. The enamel preparation contains at least 80wt.% of solvent which is a mixture of component swelling the film forming material and a component dissolving urea and the antifungal material.
Volunteers will receive dietary protein at 2.0 ± 0.2 g/kg/d within a 40% energy deficit diet. During aerobic performance testing, volunteers will receive a beverage containing 80 g glucose + 65 g fructose consumed at a rate providing \~1.8 g carbohydrate/min.
Pulmonary rehabilitation (PR) plays a crucial role in improving outcomes for individuals with chronic respiratory diseases. The most outstanding challenge in PR is the low referral, uptake, and adherence that is dramatically low in the post-hospitalization period in rural, minority, and low-income populations. Research efforts to increase the portfolio of PR through the testing and implementation of new and effective options for home-based and community-based programs are potential research targets. Other potential foci of research efforts are the pursuit of behavior-change techniques to achieve a lifestyle change during PR and the referral process to increase uptake and adherence rates. Creating new rehabilitation options for chronic lung disease that can reach more people may require expanding the definition of PR for chronic lung disease to one more flexible and perhaps concordant with the World Health Organization's definition of rehabilitation as "a set of interventions designed to optimize functioning and reduce disability in individuals with health conditions in interaction with their environment." While efforts to augment access to conventional PR are warranted, it is time to devote research efforts to reach many more individuals with chronic lung disease, particularly minorities, rural, and low-income individuals that currently have no access to any rehabilitation, a social injustice that requires action. This manuscript outlines suggested future directions in rehabilitation research with the pursuit of evidence to support feasible and effective programs that may increase the rehabilitation portfolio to accommodate most individuals with chronic lung disease.
BACKGROUND: Sarcopenia and frailty are common among elderly individuals and present substantial health hazards. Exploring their relationship is essential for optimizing geriatric healthcare, particularly within the context of China.
METHODS: A population-based cross-sectional design was employed using data from the China Health and Retirement Longitudinal Study (CHARLS). The study enrolled 5,714 participants aged ≥60 years who underwent assessment for sarcopenia following the criteria established by the Asia Working Group for Sarcopenia (AWGS 2019) in 2019. Frailty status was determined using a frailty index that categorized participants into robustness, pre-frailty, and frailty stages. Multivariable logistic regression models were employed to examine the relationship between sarcopenia and frailty and pre-frailty conditions. Subgroup and interaction analyses were performed to explore the robustness of the associations between sarcopenia and frailty across different subgroups.
RESULTS: Among the participants, 1,028 (18.0%) were identified as frailty, 2,987 (52.3%) as pre-frailty, and 645 (11.3%) had sarcopenia. Sarcopenia demonstrated an independent association with higher risks of frailty (OR = 2.13, 95% CI: 1.52-2.99) and pre-frailty (OR = 1.42, 95% CI: 1.20-1.81) in the multivariable logistic analysis. Subgroup and interaction analyses consistently demonstrated significant associations across nearly all demographic and health-related subgroups.
CONCLUSIONS: This study highlights that sarcopenia is significantly and independently associated with frailty and pre-frailty among older adults in China. Early detection and targeted interventions for sarcopenia are crucial to mitigate frailty and its adverse health outcomes in aging populations, emphasizing the need for tailored healthcare strategies to promote healthy aging.
Cohorts of participants will receive increasing doses of BT5528 and a standard dose of nivolumab. It is expected that up to 24 participants will participate in this dose-escalation combination arm.
A blood glucose meter with a low cost user interface has a color glucose scale that is indexed by indicators programmed according to the user's blood glucose target range through a separating computing device due to the limited meter user interface. The color glucose scale is static and placed adjacent to the indicator such as by being molded into the housing, printed on the housing, or attached to the display. The low cost user interface has a monochrome segmented display with certain segments serving as a plurality of indicators. An indicator scaling module uses the target blood glucose range of the person with diabetes to calculate the blood glucose ranges for each indictor to index the color glucose measurement scale. The indicator scaling module can also assign attributes to the indicator such as flashing. The graphic representation of the user's blood glucose measurement aids in user interpretation.
Male and female subjects with moderate hepatic impairment defined by a Child-Pugh score of 7-9 will be included. The subjects will be administered 40 mg oral doses of darapladib (SB-480848) enteric-coated tablets daily for 10 consecutive days.
<P>PROBLEM TO BE SOLVED: To clarify causal agent mechanisms underlying CNS cancer and other types of cancer and to provide tumor-specific therapy approach and diagnostics, as protopathic malignant central nervous system (CNS) neoplasia (especially neuroblastoma) originates in ruggedness to offensive and wide range cerebral seepage and anti-cancer disposition and is very crucial.  <P>SOLUTION: Mammal-derived biological fluid is forced to contact antibody combining with human aspartyl(asparaginyl)β-hydroxylase (HAAH) polypeptide to diagnose neoplasm of mammal, and by impeding HAAH. neoplasm is dispose. The tumor cell is forced to contact HAAH anti-sense nucleic acid to impede multiplication of neoplasm. On the methods for diagnosing neoplasm of mammal, antibody combined with human aspartyl(asparaginyl)β-hydroxylase (HAAH) polypeptide is forced to contact under sufficient conditions to form antigen-antibody complex and process is comprehend detecting the antigen-antibody complex concerned.  <P>COPYRIGHT: (C)2009,JPO&INPIT
The management of lymphatic fistulas following surgical procedures, in particular after inguinal lymphadenectomy, represents a significant clinical challenge. The current case report shows the novel use of the superficial circumflex iliac perforator (SCIP) pedicle vein for lymphovenous anastomosis (LVA) to treat a chronic inguinal lymphatic fistula in a 58-year-old male patient. This patient had developed a persistent lymphorrhea and wound dehiscence after a right inguinal lymph node biopsy performed for oncological reasons 1.5 months before. Pre-operative assessment with indocyanine green (ICG) lymphography confirmed a substantial lymphatic contribution to the wound discharge, thus guiding the surgical strategy. During the procedure, a pedicled tissue segment containing the SCIV was dissected and utilized to fill the wound's dead space and facilitate LVA with the leaking lymphatic vessel. Notably, a coupler device was employed for the anastomosis due to the large caliber of the lymphatic vessel involved, a technique not commonly reported in lymphatic surgeries. The result of the procedure was successful, with intra-operative ICG imaging confirming the patency of the anastomosis. After surgery the wound healed without complications. This case illustrates the potential of SCIV employment in lymphatic fistula repair in the inguinal region. While further research is needed to validate these findings, this report provides an unconventional approach to a relatively common problem in clinical practice.
Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis protective antigen; and cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to B. anthracis lethal factor. The invention further provides expression vectors that contain one or more cDNAs isolated according to the methods of the invention, host cells expressing one or more inventive cDNAs, and transgenic plants and animals that express one or more inventive cDNAs. In certain embodiments of the invention the expression system is a plant-based expression system. The invention further provides antibody compositions comprising one or more antibodies produced by expressing a cDNA isolated according to the methods of the invention in a suitable expression system. Additionally encompassed in the invention are kits containing one or more of provided compositions, as well as methods of production and use of provided compositions.