anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The application is a divisional application of the invention patent application, which is named 'a compound medicine composition for improving the oral bioavailability of paclitaxel and an application thereof', and has the application number of 201110004638.9 and the application date of Jan. 11, 2011. The invention discloses a compound medicine composition for improving the oral bioavailability of paclitaxel and an application thereof. The invention further discloses a medicine composition containing the compound medicine composition and a paclitaxel monomeric compound. The compound medicine composition disclosed by the invention can be used for improving the oral bioavailability of paclitaxel, and can improve the anti-cancer effect of paclitaxel in case of being used for preparing an anti-cancer medicine. In the compound medicine composition disclosed by the invention, paclitaxel is a main anti-cancer ingredient, and the monomeric compound extracted from traditional Chinese medicines improves the oral bioavailability and anti-cancer effect of paclitaxel via inhibiting a first-pass effect of paclitaxel. Experimental research indicates that the compound medicine composition disclosed by the invention can improve the blood concentration and anti-tumour effect of paclitaxel after oral administration in case of being prepared into an oral medicine.
Non-alcoholic fatty liver disease (NAFLD) has emerged as the primary risk factor for hepatocellular carcinoma (HCC), owing to improved vaccination rates of Hepatitis B and the increasing prevalence of metabolic syndrome related to obesity. Although the importance of innate and adaptive immune cells has been emphasized, the malignant transformation of hepatocytes and their intricate cellular network with the immune system remain unclear. The study incorporated four single-cell transcriptomic datasets of liver tissues covering healthy and NAFLD-related disease status. To identify the subsets and functions of hepatocytes and macrophages, we employed differential composition analysis, functional enrichment analysis, pseudotime analysis, and scenic analysis. Furthermore, an experimental mouse model for the transformation of nonalcoholic steatohepatitis into hepatocellular carcinoma was established for validation purposes. We defined CYP7A1+ hepatocytes enriched in precancerous lesions as 'Transitional Cells' in the progression from NAFLD to HCC. CYP7A1+ hepatocytes upregulated genes associated with stress response, inflammation and cancer-associated pathways and downregulated the normal hepatocyte signature. We observed that hypoxia activation accompanied the entire process of inflammation-cancer transformation. Hepatocyte-derived HIF1A was gradually activated during the progression of NAFLD disease to adapt to the hypoxic microenvironment and hepatocytes under hypoxic environment led to changes in the metabolism, proliferation and angiogenesis, promoting the occurrence of tumours. Meanwhile, hypoxia induced the polarization of RACK1+ macrophages that enriched in the liver tissues of NASH towards immunosuppressed TREM2+ macrophages. Moreover, immunosuppressive TREM2+ macrophages were recruited by tumour cells through the CCL15-CCR1 axis to enhance immunosuppressive microenvironment and promote NAFLD-related HCC progression. The study provides a deep understanding of the development mechanism of NAFLD-related HCC and offers theoretical support and experimental basis for biological targets, drug research, and clinical application.
The invention discloses a traditional Chinese medicine composition for treating stomach bleeding and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 8-12 parts of Polygonum suffultum Maxim. rhizome, 4-6 parts of Rhizoma Paridis, 4-6 parts of coptis chinensis, 6-8 parts of Cockscomb flowers, 6-8 parts of dry leaves of Callicarpa formosana Rolfe. and 6-10 parts of liquorice roots. An appropriate amount of water is added to the materials to be decocted for 30-40 minutes. The composition has the effects of achieving astringency and hemostasis, activating blood, promoting tissue regeneration, reducing swelling, relieving pain and removing heat to cool blood, and has the advantages of being quick in effect, good in treatment effect, simple in formula, free of toxic and side effects and the like for stomach bleeding caused by stomach heat, anabrosis and other situations.
LY2523355: Five milligrams per meter squared per day (mg/m\^2/day) (dosage determined by calculating participant's body surface area) administered intravenously as a 1-hour infusion on Days 1, 2, and 3 of a 21-day Cycle for 2 Cycles. Pegfilgrastim or Filgrastim: Dosage is determined by standard of care and is administered intravenously on Day 4 of 21-day Cycle for 2 Cycles. If at the end of 2 Cycles the participant was receiving benefit, the participant may have remained on study drug for additional cycles until a criterion for study discontinuation was met.
This group will consume a beetroot juice supplement (Beet It Shot®, James White Drinks, UK) that has had the nitrate removed from the beverage by the manufacturer. Patient's diet will be supplemented once daily with one 70 ml bottle while hospitalized up to 14 days.
Considering the shortcomings of known medical hemostatic materials such as bone wax for bleeding bone management, it is essential to develop alternative bone materials capable of efficient hemostasis and bone regeneration and adaptable to clinical surgical needs. Thus, in the current work, a calcium sulfate hemihydrate and starch-based composite paste was developed and optimized. Firstly, it was found that the use of hydroxypropyl distarch phosphate (HDP) coupled with pregelatinization could generate an injectable, malleable and self-hardening paste with impressive anti-collapse ability in a dynamic aqueous environment, suggesting its potential applicability in both open and minimally invasive clinical practice. The as-hardened matrix exhibited a compressive strength of up to 61.68 ± 5.13 MPa compared to calcium sulfate cement with a compressive strength of 15.16 ± 2.42 MPa, making it a promising candidate for the temporary mechanical stabilization of bone defects. Secondly, the as-prepared paste revealed superior hemostasis and bone regenerative capabilities compared to calcium sulfate cement and bone wax, with greatly enhanced bleeding management and bone healing outcomes when subjected to testing in in vitro and in vivo models. In summary, our results confirmed that calcium sulfate bone cement reinforced with the selected starch can act as a reliable platform for bleeding bone treatment, overcoming the limitations of traditional bone hemostatic agents.
A unit to treat inflammation of hemorrhoids, vulvo-vaginitis and similar conditions has a suppository and a multi-piece pad at a proximal end of the suppository. A first piece of the pad is adjacent the suppository so that medication can be applied concurrently to both. A second piece of the pad is a non-permeable layer disposed against the first piece. A third piece is an absorbent layer disposed against the second piece. A fourth piece is another non permeable layer disposed against the third piece. Medication from a container is applied to the unit through an adapter.
The AI group scanned their own mouths at home once a week for 6 months, with each scan taking approximately 5 min. After scanning, they uploaded the results to the AI system for evaluation. The AI system then selected and sent a message to each patient depending on their intraoral conditions.
BACKGROUND: Cystic, sporadic hemangioblastomas (HBLs) represent a unique, therapeutically challenging subset of central nervous system tumors, mainly due to their unpredictable growth patterns and potential for symptomatic progression. This study aims to explore the complexities surrounding the diagnosis, treatment, and long-term management of these lesions.
METHODS: A comprehensive literature review was performed, and a detailed case study of a 56-year-old patient with a cystic, sporadic cerebellar HBL was produced.
RESULTS: The case highlights the multiphasic growth pattern typical of cystic, sporadic HBLs, characterized by periods of dormancy and subsequent rapid expansion. An initial surgical intervention offered temporary control. Tumor recurrence, mainly through cystic enlargement, was treated by SRS. A subsequent recurrence, again caused by cystic growth, eventually led to the patient's death. The intricacies of treatment modalities, focusing on the transition from surgical resection to stereotactic radiosurgery (SRS) upon recurrence, are discussed. Parameters indicating impending tumor growth, coupled with symptomatic advances, are also explored.
CONCLUSIONS: The management of cystic, sporadic cerebellar HBLs requires a strategic approach that can be informed by radiological characteristics and tumoral behavior. This study underscores the importance of a proactive, individualized management plan and suggests guidelines that could inform clinical decision making.
Wnt (wingless-type) signaling pathway (WSP) alterations have been identified in patients with prostate cancer and are implicated in disease progression and hormonal resistance. In this study, we utilized a multi-institutional dataset to characterize molecular alterations in the canonical and noncanonical WSPs in prostate cancer. Patients with prostate cancer who underwent tissue-based genomic sequencing were investigated. Tumors with somatic activating mutations in CTNNB1 or RSPO2 or inactivating mutations in either APC or RNF43 were characterized as having aberrant canonical Wnt signaling (WSP-activated). Overall survival analyses were restricted to microsatellite-stable (MSS) tumors lacking RNF43 G659fs* mutations. We also investigated noncanonical WSP by evaluation of ROR1, ROR2, and WNT5 in WSP-activated versus WSP wild-type (WSP-WT) tumors. Of 4,138 prostate cancer samples, 3,684 were MSS. Among MSS tumors, 42.4% were from metastatic sites, of which 19.1% were WSP activated, and 57.6% were from the prostate, of which 10.1% were WSP activated. WSP-activated tumors were more prevalent in metastatic sites than in primary prostate cancer. WSP-activated prostate cancer exhibited more SPOP mutations and higher expression of canonical WSP activators than WSP-WT tumors. ROR1 gene expression was elevated in WSP-activated tumors from both primary and metastatic sites. M2 macrophages predominated the tumor microenvironment in WSP-activated tumors. There was no significant difference in overall survival between patients with WSP-activated and WSP-WT prostate cancer. WSP-activated prostate cancer demonstrated a more immunosuppressed tumor microenvironment and a pronounced upregulation of ROR1 gene expression, underscoring its potential involvement in the crosstalk between canonical and noncanonical WSPs. Implications: Our findings may provide a rationale for developing novel therapeutic strategies targeting Wnt-activated prostate cancer.
Subjects aged \>60 years received 1 dose of Fluarix™ Tetra (Southern Hemisphere) vaccine at Day 0. The vaccine was administered intramuscularly in the deltoid of the non-dominant arm.
BACKGROUND/AIMS: The evaluation of visceral hypersensitivity and gastric accommodation in patients with gastroparesis (GP) is difficult. CT-scan gastric volumetry allows to test the distension of different regions of the stomach. We aimed to study gastric volumes and patient's sensitivity to gastric distension between in patients with GP compared to patients with GERD.
METHOD: Retrospective study including patients who had CT-scan volumetry for GP or GERD. Two CT-scan series were made after gastric distension: left lateral decubitus 30° (LLD30) for antrum and right lateral decubitus (RLD) for body. Pain and discomfort were assessed using visual analogue scale (VAS). Gastric volumes were measured for LLD30 and RLD.
RESULTS: 13 patients (7 GP and 6 GERD) were included. Mean age was 35.6+/-7.3 years. Median gastric volume in the RLD was lower in GP vs GERD (927+/-208 ml vs. 1115+/-163 ml; p = 0.046) while it was similar for LLD30 (1053+/-228 ml vs. 1054+/-193 ml; p = 0.603). GP patients had significantly more pain and discomfort during the procedure: pain VAS for GP was 6[0-9] versus 0[0-2] for GERD, p = 0.004, discomfort VAS for GP was 7[4-10] versus 4[0-5] for GERD, p = 0.007. 66.7% of GERD patients felt no pain vs. 14.3% in GP, p = 0.053.
CONCLUSION: This pilot study suggests that GP could be associated with a reduced gastric volume compared to GERD in RLD after gaseous distension. In contrast, patient self-assessment of pain related to gastric distension was greater int GP patients. A lack of fundus accommodation and visceral hypersensitivity could explain some mechanisms in the genesis of GP symptoms.
NEW MATERIAL:The tannin of formula I (l and n are integer of 0-6; m is 0 or 1; l+m+n=6; R1 is H or G; G is group of formula II; 3 G groups are present in one molecule; there is no bond between 4-site and 4-site; the black point represents the bonding site; X is group of formula III-IV; R2 is group of formula V-VII). USE:Antipsychotic agent useful for the remedy of acute schizophrenia and chronic schizophrenia. PREPARATION:DAIO (rhizome of Pheum palmatum) is extracted with water or an aqueous solution of a water-soluble organic solvent, and the extract or its concentrate is subjected to the gel-filtration chromatography, and eluted successively with water, an aqueous solution of ethanol, ethanol, and methanol to obtain a methanol fraction. After optional concentration, the fraction is subjected to gel-filtration chromatography, and then eluted with a mixture of two or more solvents selected from methanol, ethanol, water and acetone. The eluate is subjected to high-performance liquid chromatography under specific condition, and a fraction eluted at a retention time of 10-25 min is collected. The objective compound of formula I is obtained by distilling out the solvent form the eluate.
The genome duplication program is affected by multiple factors in vivo, including developmental cues, genotoxic stress, and aging. Here, we monitored DNA replication initiation dynamics in regenerating livers of young and old mice after partial hepatectomy to investigate the impact of aging. In young mice, the origin firing sites were well defined; the majority were located 10-50 kb upstream or downstream of expressed genes, and their position on the genome was conserved in human cells. Old mice displayed the same replication initiation sites, but origin firing was inefficient and accompanied by a replication stress response. Inhibitors of the ATR checkpoint kinase fully restored origin firing efficiency in the old mice but at the expense of an inflammatory response and without significantly enhancing the fraction of hepatocytes entering the cell cycle. These findings unveil aging-dependent replication stress and a crucial role of ATR in mitigating the stress-associated inflammation, a hallmark of aging.
Matrix metalloproteinases (MMPs) play an important role in morphogenesis, angiogenesis, wound healing, and in certain disorders such as rheumatoid arthritis, tumor invasion and metastasis. MMPs are thought to be regulated by a variety of cytokines, growth factors, hormones and phorbol esters. This regulation occurs on three levels;  alteration of gene expression, activation of the latent zymogen and inhibition by the tissue inhibitors of metalloproteinases (TIMP). We report here a new agent that regulates the level of MMPs in patient. More particularly, members of the PSP94 family, when administered to patients having metastatic hormone resistant prostate cancer, promote a significant decrease in MMP plasma levels. The invention therefore relates to the use of a PSP94 family member for the treatment of a condition related to the activity or expression of MMPs.
This is a phase 1 randomized (study medication is assigned by chance), open-label (all people know the identity of the intervention), parallel-group, sequential study in healthy adult participants to investigate the effect of different storage conditions for RPV-LA on the single-dose pharmacokinetics of rilpivirine (RPV) after intramuscular injection. A total of 60 healthy adult participants will be enrolled in this study. The study will consist of 2 treatment sessions in a fixed sequential order : session 1 of up to day 8, all participants will receive a single oral dose of rilpivirine 25 milligram (mg) tablet on day 1, session 2 will consists of 2 treatment groups. The participants will be randomized in session 2 on Day 1 in a 1:1 ratio to Treatments A and B. Each treatment group will receive one IM injection of RPV LA on Day 1 of session 2. Session 1 and 2 will be separated by a washout period of at least 14 days. The total study duration for each participant will be approximately 6.5 months. Safety will be monitored throughout the study.
The invention provides an application of gypenoside XLV Ed in preparation of a hepatoma resisting medicine, and relates to gypenoside. The gypenoside XLV Ed is named as 2-hydroxy-3-O-beta-D-glucopyranose-20(S)-protopanoxadiol-20-O-beta-D-glucopyranoside which is of white powder and has a molecular formula of C42H72O14 and a molecular weight of 800. The gypenoside XLV Ed can be obtained by carrying out separation and purification step by step by utilizing a method of enzymatic conversion of gynostemma total saponins. The gypenoside XLV Ed is simple in preparation method and low in cost. By taking the hepatoma as a model, the testing of the in-vitro liver cancer resisting model shows that the gypenoside XLV Ed has an obvious effect for inhibiting the growth of human hepatoma cells SMMC7721 and Bel7402 and can used for degrading DNA in the human hepatoma cells Bel7402 into tiny fragments to promote the death of the human hepatoma cells so as to inhibit the growth of the hepatoma. Thus, the gypenoside XLV Ed can be applied to the preparation of the hepatoma resisting medicine.
Infectious diseases may lead to ocular complications including uveitis, an ocular inflammatory condition with potentially sight-threatening sequelae, and conjunctivitis, inflammation of the conjunctiva. Emerging infectious pathogens with known ocular findings include Ebola virus, Zika virus, Avian influenza virus, Nipah virus, severe acute respiratory syndrome coronaviruses, and Dengue virus. Re-emerging pathogens with ocular findings include Toxoplasma gondii and Plasmodium species that lead to malaria. The concept of One Health involves a collaborative and interdisciplinary approach to achieve optimal health outcomes by combining human, animal, and environmental health factors. This approach examines the interconnected and often complex human-pathogen-intermediate host interactions in infectious diseases that may also result in ocular disease, including uveitis and conjunctivitis. Through a comprehensive review of the literature, we review the ophthalmic findings of emerging infectious diseases, pathogenesis, and One Health perspectives that provide further insight into the disease state. While eye care providers and vision researchers may often focus on key local aspects of disease process and management, additional perspective on host-pathogen-reservoir life cycles and transmission considerations, including environmental factors, may offer greater insight to improve outcomes for affected individuals and stakeholders.
The study population consists of 30 patients with stable angina pectoris (SAP, n = 30). The diagnosis is made according to the criteria of the American Heart Association (AHA, 2014 and 2015). Patients who had autoimmune diseases, malignancies,chronic or acute infections, severe heart failure (NYHA class 3and 4) and advanced liver or renal diseases are excluded.
To provide self-healing articles.SOLUTION: Self-healing articles such as self- healing capsules for administration to a subject are provided. The self-healing article may be configured such that the article may be oriented with respect to a tissue surface or the like of the subject. The self-healing article may comprise one or more tissue engaging surfaces configured to engage the tissue surface of subject. The self-healing article may have, for example, a specific shape and/or density distribution that allows for self-healing behavior of the article. The self-healing article may contain a tissue-connecting component and/or a pharmaceutical agent (e.g., to deliver a pharmaceutically active agent to a position in a body of the subject). The self-healing article may be configured to release one or more of the tissue connecting components when the tissue comes into contact with the tissue engaging surface of the article. The tissue connection component may accompany a self-acting component. The self-healing article may comprise the self-acting component configured to release the tissue connection component from the self-healing article when exposed to a fluid. The tissue connection component may include an agent.SELECTED DRAWING: Figure 4
The investigators will incorporate 100 confirmed cases of Brucella spondylitis (BS) patients diagnosed at Affiliated Hospital of Inner Mongolia Medical University. The patients receive routine scan with a Siemens Skyra 3.0T MRI scanner and the investigators collect clinical data and blood test results from the patients.The investigators segment the affected vertebral bodies by ITK-SNAP software on STIR images to create three-dimensional regions of interest. Then use Onekey software to extract radiomics features from the affected vertebral bodies. Employed t-tests and Lasso regression to select radiomics features. Then separately use radiomics features and combining it with clinical information to build random vector machine(SVM) and random forest(RF) models . All the models are constructed in the training set and their performance are evaluated on the validation set.
The control group will receive (be offered) usual care defined as written lifestyle advices based on the general recommendations for diet (Nordic Nutrition Recommendations, 2012. Integrating nutrition and physical activity. Copenhagen: Nordic Council of Ministers, 2014) and PA (World Health Organization. World Health Organization guidelines on physical activity and sedentary behavior, 2020), including a healthy and varied diet, aiming at 300 mins/week of medium intensity aerobic PA and strength training two times per week.
The present invention relates to eatable ant food and a preparation method thereof. Eatable ant can be used as main raw material and is prepared into concentration enzymolysis liquid by breaking walls, making enzymolysis and concentrating. The concentration enzymolysis liquid and traditional Chinese medicine complex liquid with medical and appetite dual-purpose performance are fermented to prepare ant liquor. Complex type ant oral liquid uses enzymolysis liquid as main and assists with beta-cyclodextrin or a tablet auxiliary agent to prepare ant functional food, such as ant extract oral liquid, capsules or ant extract tablets. The traditional Chinese medicine complex liquid comprises the components of the following proportion: 3 to 15/1000 of Chinese wolfberry leaching liquid, 5 to 18/1000 of Chinese date leaching liquid and 3 to 16/1000 of fresh ginger leaching liquid. Complex phosphoesterasum comprises the components of the following proportion: 1 to 3% of complex proteinase, 0.5 to 1% of lysozyme and 0.05 to 0.1% of beta-glucanase. 0.2 to 1.0/1000 of beta-cyclodextrin is added into the complex type ant oral liquid. 1 to 5% of beta-cyclodextrin is added into the capsules. 1 to 8% of beta-cyclodextrin and 5 to 15% of maltodextrin are added into buccal tablets. Nutrients and effective components in ant bodies are reserved farthest by a biologic extraction method. The present invention has the functions that immunity is enhanced, free radicals are cleared, sleep is improved, blood is nourished, skins are preserved, calcium is complemented and the bones and muscles are strengthened.