anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study aims to investigate the causal relationship between primary Sjögren's syndrome (SS) and multiple sclerosis (MS) using a two-sample Mendelian randomization (MR) analysis to provide insights into their common mechanisms and implications for therapeutic strategies. We utilized data from Genome-Wide Association Studies (GWAS) for primary SS (1,290 cases and 213,145 controls) and MS (4,888 cases and 10,395 controls), restricted to European ancestry. Instrumental variables (IVs) were selected based on genetic variants associated with primary SS. The primary MR method was Inverse Variance Weighted (IVW), supplemented by MR Egger, Weighted Median, Simple Mode, and Weighted Mode algorithms to assess the bidirectional causal relationships between MS and primary SS. Sensitivity analyses, including MR-PRESSO and leave-one-out analysis, were conducted to ensure the robustness of our findings. After excluding SNPs with pleiotropic effects, 42 and 5 SNPs were identified as robust IVs for primary SS and MS, respectively. Our analysis revealed a significant protective effect of MS on primary SS, with IVW showing an OR of 0.896 (95% CI: 0.841-0.954, P = 0.001). No significant heterogeneity or horizontal pleiotropy was detected, supporting the reliability of the results. Our findings suggest a potential protective effect of MS against primary SS, indicating a negative causal association between these two autoimmune diseases. This adds valuable genetic evidence to the understanding of the complex interplay between primary SS and MS, offering new avenues for research and therapeutic interventions.
A method for preparing aerosols of water-sensitive medicaments and a pharmaceutical kit for aerosol administration are disclosed. The kit includes (a) a solid state open matrix network of a medicament in a first container;  and (b) an aqueous vehicle in a second container. The first and second containers may be separate or they may be chambers within a single housing.  The solid state network may be a unit dose of medicament, and the quantity of aqueous vehicle will then be that quantity needed to deliver one unit dose by aerosol; alternatively, the solid state network may contain a plurality of unit doses of medicament, in which case the quantity of aqueous vehicle will be that quantity needed to deliver the number of unit doses in the network.  The kit may also include a metered dose nebulizer. A preferred medicament for use in the method is formoterol.
BACKGROUND: Coronary artery calcium testing using noncontrast cardiac computed tomography is a guideline-indicated test to help refine eligibility for aspirin in primary prevention. However, access to cardiac computed tomography remains limited, with carotid ultrasound used much more often internationally. We sought to update the role of aspirin allocation in primary prevention as a function of subclinical carotid atherosclerosis.
METHODS AND RESULTS: The study included 11 379 participants from the MESA (Multi-Ethnic Study of Atherosclerosis) and ARIC (Atherosclerosis Risk in Communities) studies. A harmonized carotid plaque score (range, 0-6) was derived using the number of anatomic sites with plaque from the left and right common, bifurcation, and internal carotid artery on ultrasound. The 5-year number needed to treat and number needed to harm as a function of the carotid plaque score were calculated by applying a 12% relative risk reduction in atherosclerotic cardiovascular disease (ASCVD) events and 42% relative increase in major bleeding events related to aspirin use, respectively. The mean age was 57 years, 57% were women, 23% were Black, and the median 10-year ASCVD risk was 12.8%. The 5-year incidence rates (per 1000 person-years) were 5.5 (4.9-6.2) for ASCVD and 1.8 (1.5-2.2) for major bleeding events. The overall 5-year number needed to treat with aspirin was 306 but was 2-fold lower for individuals with carotid plaque versus those without carotid plaque (212 versus 448). The 5-year number needed to treat was less than the 5-year number needed to harm when the carotid plaque score was ≥2 for individuals with ASCVD risk 5% to 20%, whereas the presence of any carotid plaque demarcated a favorable risk-benefit for individuals with ASCVD risk >20%.
CONCLUSIONS: Quantification of subclinical carotid atherosclerosis can help improve the allocation of aspirin therapy.
In US studies, dose escalation started at a 25 mg BID dose and subsequent dose-escalation groups included: 50 mg BID, 100 mg BID, 150 mg BID, 225 mg BID and 325 mg BID. In this study, the actual dose escalation will be based on a priming dose one level below the highest safe dose or two levels below the MTD that has been tested in US clinical trials when the enrolment of the China study actually initiates, and subsequent escalated doses may be adjusted as appropriate (e.g., the escalated doses following 150 mg BID in the China study may be adjusted to 200 mg BID, 250 mg BID and 300 mg BID. The actual priming dose and subsequent escalated doses for the China study are determined by the SMC) The dose expansion stage in this study will be initiated at the MTD or the optimal dose determined by the SMC as a fixed dose level (MTD or the optimal dose needs to be reviewed by the SMC and subjects are safe and tolerable at that dose level).
Will receive 6 sessions of modified usual physiotherapy care that can consist of any physiotherapeutic modalities normally provided except exercise. this may consist of postural advice, taping, electrotherapy, acupuncture, manual joint mobilizations of the shoulder, cervical or thoracic spine.
Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a gas. The patient is scanned using ultrasound imaging to obtain a visible image of the region. In embodiments of the invention, the scanning step may comprise applying a first quantity of ultrasound energy to the patient to provide a first image, followed by the application substantially immediately thereafter of a second quantity of ultrasound energy to provide a second image. The first and second images are then processed. The methods are particularly useful for obtaining on-line images of the cardiovascular region which may be employed, for example, to diagnose the presence of diseased tissue in the cardiovascular region of a patient.
A 10-week stroke-specific rehabilitation education program for stroke patients in usual care at specialized stroke rehabilitation units. The lessons will include information on spinal cord injury rehabilitation: 1)stroke basics, 2)mental health after stroke, 3)pain after stroke, 4)understanding rehabilitation 5)summary of lessons through an online platform. A Guide will check in with participants once a week to answer any content-related questions. The Guide will spend approximately 15 minutes per week/per client.
Despite higher positive end-expiratory pressure (PEEP) being associated with multiple physiologic benefits, randomized clinical trials comparing higher vs. lower PEEP levels failed to show improved survival of ARDS patients. Higher PEEP should fully exploit its benefits only when implemented in patients with higher potential for alveolar recruitment (i.e., the decrease of non-aerated lung tissue at higher airway pressure) or in patients with airway closure. Retrospective analysis of randomised clinical trials with PEEP suggests that when high PEEP is used in responders (oxygenation), survival may be better. Conversely, in the absence of significant recruitment, higher PEEP should be avoided and lower PEEP might be recommended.

Titration of PEEP provided by the mechanical ventilator in patients with severe lung injury should thus be based on bedside information on lung recruitability. However, no valid method exists to define the best PEEP to optimize recruitment and minimize lung overdistention. Recruitability varies and is often not assessed. Electrical impedance tomography (EIT) is a non-invasive bedside imaging technique for measuring the potential for lung recruitment in ARDS patients. By performing lung (de)recruitment maneuvers and in-depth analyses, we will define lung recruitability indices and develop methods for real-time and personalized PEEP selection. This study will prove the feasibility of minimizing risks associated with inadequate mechanical ventilation by EIT.
A value of a specimen is defined so as to monotonically increase with respect to a time axis, and the value of the specimen is compared with a cost for taking a countermeasure by using a redundancy to determine the start timing of the redundancy. The start timing of the redundancy is thus adjusted, so that it is possible to reduce the period during which the countermeasure by using the redundancy is employed, thereby reducing cost. If the start timing of the countermeasure by using the redundancy is thus adjusted according to the invention, the countermeasure by using the redundancy is not always taken from the beginning of testing as shown in FIG. 2(b) but is started after, say, 19 months have passed as shown in FIG. 2(c). Accordingly, it is possible to prevent overinvestment (in this example, overinvestment of 18 months) as compared to the case in FIG. 2(b).
The use of hydroxyzine (I), or its optical isomer or salt, is claimed in the production of a medicament for preventing the onset or reducing the intensity and severity of post-traumatic stress syndrome. ACTIVITY : Tranquilizer. Patients subjected to a traumatic event (as defined by known severity and response criteria), showing arterial hypertension, tachycardia and increased salivary cortisol symptoms, were treated orally at random with 0.75 mg/kg of (I) or placebo for one month. Results, evaluated 1-3 months after the event using the clinician-administered PTSD scale (see J. Trauma-Stress, Jan. 1995, Vol. 8 (1), 75-90), showed that administration of (I) for a short period with (I) immediately after the event significantly reduced the risk of development of post-traumatic stress syndrome. MECHANISM OF ACTION : None given.
ETHNOPHARMACOLOGICAL RELEVANCE: Sa-Tri-Lhung-Klod (ST) remedy is a Thai traditional remedy used in obstetrics and gynecology to reduce inflammation and nourish the body post-partum. In Thai traditional medicine (TTM), there is a theory of formulating drugs based on the four elements and the tastes of herbs for use in treating diseases.
AIMS OF STUDY: To determine relationships between taste theory and pharmacological properties for the anti-inflammatory effect of ST remedy and its chemical constituent components. To evaluate anti-inflammatory activity and also investigate the HPLC fingerprint of ST extracts.
MATERIALS AND METHODS: ST remedy was extracted by maceration in 95% ethanol (STE) and decoction in distilled water (STW). ST extracts were evaluated for anti-inflammatory activity by nitric oxide inhibitory assay in RAW264.7 cells, carrageenan-induced rat paw edema, and prostaglandin E2 inhibitory assay in inflamed rat paw tissue. In addition, the chemical constituent fingerprints of ST extracts were examined using HPLC.
RESULTS: STE contained seven main chemical compounds, and STW demonstrated only one identifiable chemical compound. The STE and STW displayed potent NO inhibitory activity with an IC50 value of 20.59 ± 0.03 and 52.93 ± 0.90 μg/mL, respectively. Moreover, the STE and STW (at doses of 100 - 400 mg/kg) promoted significant inhibition of inflammation in carrageenan-induced paw edema in rats (20.81 - 38.25%). Additionally, the STE (200 - 400 mg/kg) and STW (100 - 400 mg/kg) significantly reduced PGE2 levels in inflamed rat paw tissue.
CONCLUSION: These findings suggest that the spicy, astringent, sweet, and fragrant taste of the ST remedy used to treat post-partum inflammation encompass constituents with potent anti-inflammatory activity. STE and STW possess anti-inflammatory properties and effectively inhibit the production of NO and PGE2. Results confirm the use of the ST remedy for treating inflammatory diseases in the post-partum period according to TTM knowledge.
A system and method for automatically interpreting EEG signals is described. In certain aspects, the system and method use a statistical model trained to automatically interpret EEGs using a three-level decision-making process in which event labels are converted into epoch labels. In the first level, the signal is converted to EEG events using a hidden Markov model based system that models the temporal evolution of the signal. In the second level, three stacked denoising autoencoders (SDAs) are implemented with different window sizes to map event labels onto a single composite epoch label vector. In the third level, a probabilistic grammar is applied that combines left and right context with the current label vector to produce a final decision for an epoch. A physician's report with diagnoses, event markers and confidence levels can be generated based on output from the statistical model. Systems and methods for dealing with channel variation or a missing EEG electrode valve are also disclosed. A feature-space boosted maximum mutual information training of discriminative features or an iVectors technique to determine invariant feature components can be implemented for generating a plurality of EEG event labels. An optional GUI allows scrolling by EEG events.
Prebiotics (inulin), 10g per day. Vitamin D3 placebo.
BACKGROUND: Increased intestinal permeability and dysbiosis are related to obesity. Nuts can provide nutrients and bioactive compounds that modulate gut microbiota and inflammation, enhancing the beneficial effects of weight loss.
OBJECTIVES: To evaluate the effect of consuming cashew nuts (Anacardium occidentale L.) and Brazil nuts (Bertholletia excelsa H.B.K) on intestinal permeability and microbiota, fecal SCFAs and pH, inflammation, and weight loss in energy restriction condition.
METHODS: In this 8-week randomized controlled trial, 40 women with overweight or obesity were assigned to energy-restricted groups (-500 kcal/d): control group (free of nuts) or Brazilian nuts group (BN: 30 g of cashew nuts and 15 g of Brazil nuts per day). Permeability was analyzed by the lactulose/mannitol test and the microbiota by sequencing the 16S gene in the V3-V4 regions. Plasma concentrations of inflammatory cytokines (TNF, IL-6, IL-10, IL-8, IL-17A) and C-reactive protein were analyzed.
RESULTS: In total, 25 women completed the intervention. Both groups lost weight without statistical differences. Lactulose excretion increased only in the control group (P < 0.05). The BN consumption increased fecal propionic acid and potentially beneficial bacteria, such as Ruminococcus, Roseburia, strains NK4A214 and UCG-002 from the Ruminococcaceae family, but also Lachnospiraceae family, Bacteroides, and Lachnoclostridium, when compared to the control group. Changes in intestinal permeability were correlated to a greater reduction in body fat (kg), and IL-8, and increases in Ruminococcus abundance.
CONCLUSION: Our findings demonstrate a positive impact of BN consumption within an energy-restricted context, linked to the augmentation of potentially beneficial bacteria and pathways associated with body fat reduction. Besides, BN consumption mitigated increased intestinal permeability, although its capacity to diminish permeability or enhance weight loss proved limited. This trial was registered at the Brazilian Registry of Clinical Trials as ReBEC (ID: RBR-3ntxrm).
FIELD: food industry. SUBSTANCE: product may be used as general-restorative nourishing additive designed for activization of immune system and prophylaxis of oncodiseases; product may be used for introduction in food products applied for improvement and prophylaxis of diseases of osteomuscular system and connective tissues. The proposed product is fermentative hydrolyzate from cartilaginous tissue of sharks of the following species: Lamna ditropis, Halaerurus buergeri, Galeocerdo cuvier, Sgualus acanthias, Somniosus antarcticus, Somniosus pacificus. The product contains free amino acids in the amount no less 20 mas.% including aromatic amino acids: tryptophan, tyrosine and phenylalanine which total content is no less 22%; diamino acids: lysine and agrinine, no less 19%; dicarboxylic amino acids - aspartic and glutamic ones, no less 17%; glycine, no less 6%; taurine, no less 1.5% from total quantity of amino acids; the product also includes hyaluronic acid in the amount of 2.1-5.5 mg/g of dry product. Method of product preparation involves homogenization of tissue, extraction of ground raw material and separation of final product. Extraction is conducted by 0.9-2.0-% solution of sodium chloride for 10-18 h at temperature 5-10 C. Then fermentative hydrolysis is carried out by proteolytic ferment preparations at temperature 30-45 C for 15-24 h. Inactivization of ferments is carried out by heating up to 70-80 C for 15-20 min, and separation of prepared product after inactivization is conducted through calico filter. EFFECT: broadened assortment of food treatment-and-prophylactic products with higher biological activity. 9 cl, 3 ex
<P>PROBLEM TO BE SOLVED: To provide a new approach for the therapy of allergic responses.  <P>SOLUTION: The chimeric protein comprises a cell targeting moiety for FcεRI expression cells, preferably, Fc site of a mouse IgE molecule and a cell killing moiety. Preferably, the chimeric protein contains a bacterial toxin Pseudomonas exotoxin (PE). The chimeric protein specifically and efficiently kills mouse mast cell lines expressing the FcεRI receptor, as well as primary mast cells derived from bone marrow. The pharmaceutical composition for the treatment of allergic diseases and for the treatment of hyperplasia and malignant tumor utilizes the chimeric protein.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Ear acupuncture is a affordable, easy and non-invasive method with good evidence of effectiveness in the scope of physical training. Several previous studies has proven the effectiveness of acupuncture in physical exercise, including helping increases oxygen absorption and reduces lactic acid after exercise, lowering chronic musculoskeletal pain. Lin's 2011 research found that in the third minute twenty and sixty after exercise, the auricle acupuncture group had levels blood lactic acid was lower than the sham ear acupuncture control group. In reducing pain after physical activity, ear acupuncture has been shown to reduce VAS leg intensity is 2 scores. This shows that ear acupuncture can helps athletes recover after intense training faster. At the Defense University of the Republic of Indonesia (UNHAN RI), Study Program students Bachelor of Medicine (cadet) has both academic demands and military training. Spring education The military demands high stamina and physical fitness. To make sure the cadets are in a fit condition to face daily activities with a busy and numerous schedule physical activity, a physical fitness assessment is carried out at the end of each semester using the 12 run test. By doing this test, we can get an idea regarding the cadet's ability to carry out physical activities. For this reason, this research aims to observe the effect of giving ear press needle acupuncture on running 12 minutes in Indonesian Defense University student of medical faculty.
PCT No. PCT/FR93/00879 Sec. 371 Date May 18, 1995 Sec. 102(e) Date May 18, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06407 PCT Pub. Date Mar. 31, 1994Cosmetic composition for the skin or skin appendages comprising a dispersion of solid particles in a binder and characterized in that at least a part of said particles is introduced into the composition in the form of particles having their surface coated with at least one amphoteric polymer. The coated particles are easily dispersible, even in fatty binders, and the cosmetic compositions have good stability properties and show good adhesion to the skin and skin appendages.
Dissolving the lipid droplets in tissue section with alcohol during a hematoxylin and eosin (H&E) stain causes the tumor cells to appear like clear soap bubbles under a microscope, which is a key pathological feature of clear cell renal cell carcinoma (ccRCC). Mitochondrial dynamics have been reported to be closely associated with lipid metabolism and tumor development. However, the relationship between mitochondrial dynamics and lipid metabolism reprogramming in ccRCC remains to be further explored. We conducted bioinformatics analysis to identify key genes regulating mitochondrial dynamics differentially expressed between tumor and normal tissues and immunohistochemistry and Western blot to confirm. After the target was identified, we created stable ccRCC cell lines to test the impact of the target gene on mitochondrial morphology, tumorigenesis in culture cells and xenograft models, and profiles of lipid metabolism. It was found that mitofusin 2 (MFN2) was downregulated in ccRCC tissues and associated with poor prognosis in patients with ccRCC. MFN2 suppressed mitochondrial fragmentation, proliferation, migration, and invasion of ccRCC cells and growth of xenograft tumors. Furthermore, MFN2 impacted lipid metabolism and reduced the accumulation of lipid droplets in ccRCC cells. MFN2 suppressed disease progression and improved prognosis for patients with ccRCC possibly by interrupting cellular lipid metabolism and reducing accumulation of lipid droplets.
All the Low dose computed tomography of lung was performed with 64 slices multidetectors CT in single hold breath covering entire lung. The protocol of scanning parameters (120KVp, 40-80 mA, 1.25 mm or less in thickness) was standardized. The raw data would be reconstructed to axial images (3 mm thickness and interval) and coronal images (3 mm thickness and interval). The scan should be finished in a single breath (15-20 second) from the thoracic inlet to adrenal glands.
No contact lens wear for the duration of the study. One 8-hour sleep at 1 week, followed by an 8-hour sleep 4 weeks later.
PROBLEM TO BE SOLVED: To form the skin having moisture and the hair having good luster when a beauty sheet used for moisture retaining of the human skin is brought into contact with the human skin and hair by carrying alginate on a fiber sheet. SOLUTION: This beauty sheet is used by cutting the sheet to a fixed shape and size and is formed by depositing the alginate 2 on the fiber sheet 1. At this time, the beauty sheet is preferably formed by fixing the plural fiber sheets 1 to each other and depositing the alginate 2 between the fiber sheets 1 and more adequately depositing the alginate 2 at 10 to 40wt.% thereon. The beauty sheet may otherwise be formed by thermally adhering the ends of the circumference of the sheets to a bag form and encapsulating the alginate 2 therein. According to such beauty sheet, water is included in the sheet and a required part is lightly rubbed and putted, by which the alginate 2 is imparted to the skin and the moisture is imparted to the skin as well. The sheet is also usable as a pack by sticking the sheet to a necessary part.