anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of the current application is to examine the utility and validity of National Institute on Alcohol Abuse and Alcoholism's (NIAAA)new definition of recovery within the context of a novel theoretical model. The proposed study will recruit participants seeking treatment for Alcohol Use Disorder (AUD) from the community. Participants will complete a structured clinical interview and provide information on their current alcohol use and related behaviors. All participants will receive 12 weeks of AUD psychotherapy and complete brief assessments at the end of each treatment session and biweekly during the first 12-months post treatment. In addition, participants will complete in-person interviews at 3-month and 6-month intervals post-treatment for the duration of the study (for up to 24-54 months post treatment depending on time of enrollment). Findings from the proposed research have the potential to increase understanding of the dynamic nature of recovery and thereby improve clinical decision-making and generate future research. Specifically, our goal is to address the question of "Are the constructs of relapse, recurrence remission, or recovery useful heuristics for clinical practice and research, and if so, how?"
Subjects aged 6 to 10 weeks at the time of first vaccination received 3 doses of Tritanrix™ HepB/Hib and Polio Sabin™ at Months 0, 1 and 2, 3 doses of GSK 257049 vaccine at Months 0, 1 and 7, and a single dose of Rouvax™ and Stamaril™ at Month 7. The GSK 257049 and Tritanrix™ HepB/Hib vaccines were administered intramuscularly in the left and right antero-lateral thigh, respectively. Rouvax™ and Stamaril™ were administered intramuscularly in the left and right arm respectively. Polio Sabin™ was administered orally. Stamaril™ was not administered to subjects from Tanzania as this vaccine was not foreseen at the time to be introduced to the EPI vaccination schedule in Tanzania.
PCT No. PCT/EP94/03937 Sec. 371 Date Jun. 10, 1996 Sec. 102(e) Date Jun. 10, 1996 PCT Filed Nov. 28, 1994 PCT Pub. No. WO95/15953 PCT Pub. Date Jun. 15, 1995   <IMAGE>  (I)  The invention relates to novel substituted oxazolidines of formula (I) wherein R1 and R2 are simultaneously hydrogen or both together are the identical lower alkyl radical, and to the salts thereof in racemic and chiral form, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments. The compounds have a stimulating effect on beta-adrenergic receptors and can be used, inter alia, for the treatment of diseases associated with reversible obstruction of the respiratory tract, typically asthma and chronic bronchitis, and also for inflammation of different origin.
Sigmoid volvulus is frequently seen in male patients over 60 years old. Here, the investigators aimed to investigate the causes of sigmoid volvulus developing in patients under 60 years of age. Patients diagnosed with sigmoid volvulus between 2009 and 2018 were retrospectively screened. The patients were divided into two as under 60 years old and above. The co-morbidity, mortality, morbidity, complications, age and gender data of the patients were analyzed. In the sigmoid volvulus \<60 age groups, the male/female ratio is close to each other. If sigmoid volvulus develops in \<60 age groups, it is more likely to be another underlying organic pathology.
Patients receiving intraoperative dexmedetomidine infusion. Infusion duration: from 10 minutes after anesthetic induction to the end of surgery.
For CFP counting, insulin dose will be calculated according the carbohydrate content (1 carb unit = 10 g carbohydrate) as well as fat/protein content (1 FPU = 100 kcal from fat and protein) of the meal. The insulin-to-carbohydrate ratio will be applied according to the current individual therapy of the patient. The insulin-to-FPU ratio is the same as the insulin to carb ratio.
The present invention relates to the field of pharmaceutical preparations. Specifically disclosed is a compound amino acid enteric-coated tablet for dogs. Raw materials for preparing active ingredients of the tablet comprise leucine, isoleucine, valine, glycine, proline, alanine, lysine hydrochloride, arginine hydrochloride, serine, threonine, histidine hydrochloride, methionine, phenylalanine, tryptophan, starch, sodium carboxymethyl starch, magnesium stearate, sodium carboxymethyl cellulose, a suspension A, and a suspension B. The steps for preparing the compound amino acid enteric-coated tablet for dogs comprise: preparing a tablet core, preparing an isolation layer, and preparing an enteric coating layer. The compound amino acid enteric-coated tablet for dogs reduces adverse reactions caused by stimulation to the stomach and supplements the requirements of dogs for amino acids, and the preparation method thereof is simple to operate. The preparation method is suitable for preparing the compound amino acid enteric-coated tablet for dogs, and the prepared compound amino acid enteric-coated tablet for dogs is suitable for dogs.
BACKGROUND: Spontaneous or non-traumatic bladder rupture is rare but can be life-threatening. Bladder rupture caused by a diverticulum is extremely rare, with only a few case reports in medical literature.
CASE PRESENTATION: We report the case of a 32-year-old woman admitted to hospital complaints of abdominal pain, oliguria and ascites with no history of trauma. Laboratory tests revealed an elevated serum urea nitrogen(UN) level of 33.5 mmol/l and an elevated creatinine levels of 528 umol/l. X-ray cystography confirmed the rupture of a bladder diverticulum. Subsequent transurethral catheterization led to a prompt increase in urinary output, and serum creatinine level returned to 40 umol/l within 48 h. The patient was successfully treated with laparoscopic diverticulectomy.
CONCLUSION: Clinicians should maintain a high level of suspicion for urinary bladder rupture in cases presenting with acute lower abdominal pain, urinary difficulties, and oliguria. When acute renal failure, complicated ascites, and an elevated peritoneal fluid creatinine or potassium level exceeding serum levels are observed, intraperitoneal urine leakage should be suspected without delay. This case emphasizes the importance of early diagnosis and intervention in managing this rare but serious condition.
Radiation therapy - 60 Gy in 6 weeks (2 Gy once a day, 5 x a week) plus Cisplatin-100 mg/m2 i.v. on days 1,22 and 43 with radiation therapy.
FIELD: medicine, particularly, medicaments on vegetable base. SUBSTANCE: skin oil may be used as softening, disinfecting and nourishing agent in cosmetology. Polyvitamin oil contains coniferous provitamin concentrate and fir-tree oil at the following ratio of components, mas.%: coniferous provitamin concentrate, 30-70; fir-tree oil, 30-70. The oil stimulates perspiration after bath house and sauna, and intensifies discharging of metabolic products together with sweat. The oil has no allergic action. EFFECT: improved skin stimulation. 2 tbl
PRADAXA Capsules should be swallowed whole. PRADAXA Capsules should be taken with a full glass of water. Breaking, chewing, or emptying the contents of the capsule can result in increased exposure [see Clinical Pharmacology (12.3)].

If a dose of PRADAXA Capsules is not taken at the scheduled time, the dose should be taken as soon as possible on the same day; the missed dose should be skipped if it cannot be taken at least 6 hours before the next scheduled dose. The dose of PRADAXA Capsules should not be doubled to make up for a missed dose.

Consider administration with food if gastrointestinal distress occurs with PRADAXA Capsules.
Peripheral artery (PAD) disease in association with renal artery stenosis is an important association which predicts the severity of the disease. An increase in the number of vessels affected by peripheral artery disease increases the chances of renal artery stenosis. In our case, the patient had primarily presented with anginal chest pain with complaints of claudication which on further investigation was diagnosed to be a triple vessel coronary artery disease along with bilateral subclavian and bilateral renal stenosis. On detailed history taking, risk factors like hypertension and chronic smoking was found to be present in our case which predisposed to peripheral artery disease secondary to atherosclerosis which was diagnosed on further investigations. Although the association of renal artery stenosis is not very rare in cases of severe peripheral vascular diseases, the presence of a triple vessel coronary artery disease in synchrony is what makes it unique. Take away lesson from this case report is importance of early diagnosis of dyslipidemia causing atherosclerosis and its complications. Multiple atherosclerotic lesions in synchrony i.e, bilateral renal artery stenosis with bilateral subclavian artery stenosis with coronary artery triple vessel atherosclerotic disease like in our case and its severity should create awareness among health care individuals and early treatment measures including lifestyle modifications should be considered to avoid such drastic events.
The present invention relates to a cosmetic composition for inhibiting skin damage caused by ultraviolet rays containing fermented mycelium of Leatiporus sulphureus var. miniatus of a Scutellaria baicalensis extract. The fermented mycelium of Leatiporus sulphureus var. miniatus of the Scutellaria baicalensis extract is confirmed to inhibit the thickening of the skin during the development of the skin damage induced by ultraviolet irradiation. Therefore, a cosmetic composition having an excellent skin damage inhibiting effect is expected to be developed by using the fermented mycelium of Leatiporus sulphureus var. miniatus of the Scutellaria baicalensis extract.
Glioblastoma (GBM) is a highly aggressive primary malignant brain tumor with a dismal prognosis despite current treatment strategies. Inflammation plays an essential role in GBM pathophysiology, contributing to tumor growth, invasion, immunosuppression, and angiogenesis. As a result, pharmacological intervention with anti-inflammatory drugs has been used as a potential approach for the management of GBM. To provide an overview of the current understanding of GBM pathophysiology, potential therapeutic applications of anti-inflammatory drugs in GBM, conventional treatments of glioblastoma and emerging therapeutic approaches currently under investigation. A narrative review was carried out, scanning publications from 2000 to 2023 on PubMed and Google Scholar. The search was not guided by a set research question or a specific search method but rather focused on the area of interest. Conventional treatments such as surgery, radiotherapy, and chemotherapy have shown some benefits, but their effectiveness is limited by various factors such as tumor heterogeneity and resistance.
OBJECTIVE: In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the thyroid isthmus. This method, hereinafter defined as high tracheostomy, has the advantage of facilitating immediate access to the trachea in a superficial position; moreover, it can be quickly replaced with cricothyrotomy in emergency situations. However, tracheotomies placed too high can potentially damage the cricoid cartilage, thereby causing subglottic granulation and tracheal stenosis. We aimed to validate the safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus.
METHODS: This was a retrospective cohort analysis. We analyzed the operative method and other relevant characteristics of 90 patients who underwent surgical tracheostomy between April 2016 and June 2022. For those who underwent high tracheostomies, we analyzed the duration of surgery, amount of intraoperative bleeding, occurrence of complications, problems with stoma closure, and perioperative mortality.
RESULTS: High tracheostomy was performed in 73 patients. Subglottic granulation occurred in one patient, and the granulation tissue spontaneously shrank. Subcutaneous emphysema occurred in two patients. No patient developed wound infection or tracheoinnominate artery fistula. Moreover, no patient experienced false route tracheotomy tube insertion because the thyroid glands were located under the stoma.
CONCLUSION: The frequency of complications was comparable to that reported in other studies on tracheostomy. Additionally, no patient developed tracheal stenosis secondary to tracheostomy above the thyroid isthmus. Therefore, high tracheostomy with inferior retraction and preservation of the thyroid isthmus is safe and advantageous.
In one embodiment, a stationary exercise station is provided. The stationary exercise station includes a computer which may run a computer program. The computer program simulates the motion of a first virtual bicycle and a second virtual bicycle. The first virtual bicycle and the second virtual bicycle riding through a predetermined landscape. The computer program simulates moving images seen by the virtual rider of the first virtual bicycle while riding through the predetermined landscape. 
     The stationary exercise station also include a video monitor in communication with the computer. The video monitor displays the moving images seen by the virtual rider of the first virtual bicycle while riding through the predetermined landscape. The stationary exercise station also includes steerable handlebars, rotatable pedals, a force resisting pedal rotation, and a movable gear-shifting member. The motion of the virtual bicycle is determined by the steering of the steerable handlebars, rotation of the rotatable pedals, and motion of the moveable gear-shifting member. The force resisting pedal rotation is proportional to the slope experienced by the virtual bicycle riding through the predetermined landscape.
The overall goal of this study is to determine if using high-intensity, short-duration, intermittent neuromuscular electrical stimulation (NMES) is better than volitional exercise in increasing quadriceps femoris and triceps surae force-generating potential and gross motor function in children with cerebral palsy. This study consists of a randomized controlled trial in which the effects of NMES applied to the quadriceps femoris and triceps surae are compared to the effects of volitional isometric exercise and a non-exercising control group. This project assesses the ability of NMES to increase muscle force generating ability, the mechanisms behind changes in force generating ability, and the effects of training on spatiotemporal parameters of gait and gross motor function in children with cerebral palsy.

Subjects is the NMES group will be implanted with percutaneous electrodes in the medial and lateral heads of the gastrocnemius and the quadriceps (3 electrodes in each lower extremity, implanted bilaterally). During the intervention phase, these subjects will undergo 15 electrically-elicited contractions in each of the implanted muscle groups three times/week (at home), while positioned on an exercise board to maintain good alignment and facilitate isometric contractions. Subjects in the volitional group will perform 15 isometric contractions in each muscle group (quadriceps, triceps surae), while positioned on an exercise board. The non-exercise control group will continue with typical activities, but no intervention will be administered. Subjects are assessed at baseline, 6 weeks into the intervention, 12 weeks into the intervention (at which point the intervention is withdrawn), and at a follow-up assessment 12 weeks after the withdrawal of the intervention.
Participants in the SOC will not meet in study groups, thus are more "at risk" for attrition. They will be contacted by the study team on a monthly basis to check in and ensure their documented contact information remains accurate. SOC may vary by site depending on clinic structure, referral systems, and group activities. These differences could potentially dilute the SYV intervention effect and introduce content spillover whereby participants randomized to the intervention discuss intervention content with participants randomized to SOC. As part of the study survey, participants will be asked if they had friends who attended the SYV intervention and if they discussed content. Additionally, as part of the implementation science outcomes (Aim 3), the SOC group structure, adherence counseling, and any mental health referrals offered as part of SOC will be documented.
A method for treating the duodenal ulcer and the chronic gastroduodenitis comprises the drugs, the diet, the physiotherapy, and the subcutaneous injections of the absorbed staphylococcus anatoxin: first, in the hip bilaterally, 7 days later in the shoulder bilaterally and finally 7 days later in the subscapular areas. Beforehand, the foci of the chronic infection are sanitized. Then the absorbed staphylococcus anatoxin is administered: first in a volume of 0.25 mL, the second time – 0.5 mL, and the third time –1.0 mL. The patients with blood groups 0 (І) and В (III) are immunized only twice: in the hip and in the shoulder. All the patients are reimmunized in 7-8 months with 0.5 mL of preparation administered in one subscapular area. In the case of the pronounced skin allergic reaction, the next injection is provided in 10-14 days with half a dose.
First-tier genetic investigations for patients with neurodevelopmental disorders (NDDs) may include chromosomal microarray, Fragile X testing, and screening for inherited metabolic diseases, but most remain undiagnosed upon completion of testing. Here, we report the diagnostic yields of genetic testing for 537 patients with at least one of autism spectrum disorder, global developmental delay, and/or intellectual disability. Patients were assessed in a single neurodevelopmental genetics clinic, and each underwent a standardized history and physical examination. Each patient was characterized as syndromic or nonsyndromic based on clinical features. Our results demonstrate that multigene sequencing (with an NDD gene panel or exome) had a higher diagnostic yield (8%; 95% confidence interval [CI]: 5%, 13%) than chromosomal microarray and Fragile X testing combined (4%; 95% CI: 3%, 7%). Biochemical screening for inherited metabolic diseases had a diagnostic yield of zero. The diagnostic yield of genetic testing was significantly higher for syndromic patients than for nonsyndromic patients (odds ratio [OR] 3.09; 95% CI: 1.46, 6.83) and higher for female patients than for male (OR 3.21; 95% CI: 1.52, 6.82). These results add to the growing evidence supporting a comprehensive genetic evaluation that includes both copy number analysis and sequencing of known NDD genes for patients with NDDs.
The utility model relates to a long-acting Chinese medicine waist line which is used for treating a chronic lumbocrural pain. The utility model comprises an oblong Chinese medicine waist line, a movable type fixing bridle and a bottle of concentrated synergistic agents. When Chinese medicine waist line is used for some time, and a medicine effect reduces to an unobvious treatment function, the number of old vinegar and spirits are added into the concentrated synergistic agents in a bottle to prepare regenerating synergistic liquid to be sprayed on the surface of a medicine core, so the Chinese medicine waist line can be continuously used. The surface of the medicine core is sprayed once every 4-5 days, so every waist line can be repeatedly used for 50-70 days. The utility model saves a resource, lightens the economic burden of a patient, and has the advantages of convenience, practicality, comfort wearing and no clothing pollution. The utility model can enforce painless treatment at any time in various sites. The utility model is used on the long term treatment of lumbar muscle strain, the prolapse of a lumbar intervertebral disc, etc. The patient easily accepts the utility model. The utility model is deeply appraised by the patient since the utility model has been applied to a clinic for two years. The effective rate of the utility model reaches 94.17% through the clinical observation of 120 examples.
1. Technical Result Increase in efficiency of treatment and prevention of infection by HIV. 2. Essence Hydroxypyrimidin-carboxamides of formula are described wherein the values of radicals are defined in the description. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. 3. Field of Application Medicine.
The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-.alpha.) and/or tumor necrosi s factor alpha receptor (TNFR). Preferably, the complexes comprise at least on e polypeptide selected from the group consisting of: NF-~B activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity o f the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-.alpha. related diseases.
A method is provided for obtaining a vaccine against the different pathogenic serotypes of group B Neisseria meningitidis characterized by starting from live microorganisms of any one of the known pathogenic serotypes of the B group without inactivation, from which the extractation of the vesicles of the outer membrane and the protein antigenic complex of 65 - 95 KD molecular weight is carried out using detergent, enzyme and ultrasound combined in the treatment. The resulting product, after treatment to eliminate the nucleic acids, is purified by a dissociating treatment with detergent, ultrasonic bath and column chromatography. The multi-antigenic material so obtained is purified to obtain the protein antigenic complex of 65 - 95 KD molecular weight for HPLC chromatography (TSK 3000 SWG column) or affinity chromatography with monoclonal antibodies, or hydrophobicity chromatography, or ionic exchange chromatography or a combination of any one of them. The protein antigenic complex is then added to the fraction that contains the vesicles by ultrasound treatment so that it will be anchored on then, in a proportion of 15 por cent +/- 3. The capsulr polysaccharide is also added, in a proportion of 1.1 - 1.4 with respect to the protein and the adjuvant in a relation ranging from 2 - 100 mcg/protein mcg. The different components ot the mixture may be sterilized by cobalt 60 inonizing radiations with doses from 5 - 25 Kgy and a temperature between 1 - 4 grade C before preparing the mixture or the resulting mixture may be sterilized by this procedure.