anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Phenohytro™ Tablets can cause fetal harm when administered to a pregnant woman. Animal reproduction studies have not been conducted with Phenohytro™. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.

In the presence of a high environmental temperature, heat prostration (fever and heatstroke due to decreased sweating) can occur with belladonna alkaloids.

Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. Administration of Phenohytro™ Tablets to a patient exhibiting diarrhea would be inappropriate and possibly harmful.

Phenohytro™ Tablets may produce drowsiness or blurred vision. Should these occur, the patient should be warned not to engage in activities requiring mental alertness, such as operating a motor vehicle or other machinery, and not to perform hazardous work.

Phenobarbital may decrease the effect of anticoagulants, and necessitate larger doses of the anticoagulant for optimal effect. When the phenobarbital is discontinued, the dose of the anticoagulant may have to be decreased.

Phenobarbital may be habit forming and should not be administered to individuals known to be addiction prone or to those with a history of physical and/or psychological dependence upon drugs.

Since barbiturates are metabolized in the liver, they should be used with caution and initial doses should be small in patients with hepatic dysfunction.
Long-term musical training induces adaptive changes in the functional representation of the motor cortex. It is unknown if the maladaptive plasticity associated with chronic pain, frequently affecting trained musicians, may alter the use-dependent plasticity in the motor cortex. This study investigated the interaction between adaptive and maladaptive plasticity in the motor pathways, in particular how chronic pain influences long-term use-dependent plasticity. Using transcranial magnetic stimulation (TMS), corticospinal excitability was assessed by measuring the amplitude of the motor-evoked potential (MEP), area of the motor map, volume, and center of gravity of the first dorsal interosseous muscle in 19 pain-free musicians, 17 upper limb/neck pain chronic pain musicians, and 19 pain-free non-musicians as controls. Motor map volume and MEP amplitude were smaller for both pain-free and chronic pain musicians compared to pain-free controls (P < 0.011). No significant differences were found between musicians with and without chronic pain. These findings confirm that long-term musical training can lead to focalized and specialized functional organization of the primary motor cortex. Moreover, the adaptive use-dependent plasticity acquired through fine-motor skill acquisition is not significantly compromised by the maladaptive plasticity typically associated with chronic pain, highlighting the potential of long-term sensorimotor training to counteract the effects of chronic pain in the motor system.
Pharmaceutical compsns. contain, apart from a diluent or vehicle, a flavylium salt of formula (I) as active ingredient. In the formula, each Y is independently OH or 1-6C alkoxy; m = 0-6; n = 0-5; m+n = 1-11; and X is a pharmaceutically acceptable anion. The use of cyanidin; peonidin; delphinidin; petunidin; malvidin and pelargonidin is excluded. (I) induce cicatrisation and epithelial regeneration so are useful in treating wounds and gastric or duodenal ulcers. They also have antiinflammatory, vasoprotecting, hypolipidaemic, hypocholeserolaemic and hypoglycaemic activities.
PURPOSE: A low irritative cleansing composition is provided to lower irritation to skin and use for patient of atopic dermatitis and acne. CONSTITUTION: A low irritative cleansing composition contains non-ionic surfactant, anionic surfactant, amphiprotic surfactant and rhodiola extract. The non-ionic surfactant is alcohol ethoxylate, amide ethoxylate, amine oxide, alkyl glucoside, or their mixture. The anionic surfactant is phosphate ester, soap, isothionate, sulfate, sulfonate, taurate or their mixture. The amphiprotic surfactant is betaine, glycinate, alkylamido alkyl amine or their mixture. The cleansing composition further contains polyol selected from glycerin, diprotyleneglycol, propyleneglycol, 1,3-butyleneglycol, polyethyleneglycol or their mixture.
Thunderclap headache is a sudden severe headache with onset to peak within one minute. Multiple excruciating, short-lived thunderclap headaches over a few days to weeks are highly suggestive of reversible cerebral vasoconstriction syndrome (RCVS). RCVS can be primary or secondary to several factors, but it is rarely described after neuro-endovascular procedures using onyx material. A 10-year-old child presented with RCVS heralded by recurrent thunderclap headache following endovascular embolization of pial arteriovenous malformation with onyx material (contains organic solvent dimethyl sulfoxide). Dimethyl sulfoxide is an angiotoxic material that can cause dysregulation of cerebral vascular tone triggering reversible cerebral vasoconstriction syndrome. Recurrent thunderclap headache after embolization procedures using onyx material should prompt for the diagnosis of reversible cerebral vasoconstriction syndrome.
<P>PROBLEM TO BE SOLVED: To provide an extract-containing composition for moisture dispersion that is powdered and easily handleable and becomes dispersion having excellent transparency when dissolved in water, never degenerates under refrigeration/freezing and provide beverage using the same.  <P>SOLUTION: Two pts.wt. of moisture ethanol is added to 1 pt.wt. of crushed propolis and they are stirred, extracted and filtered to obtain a propolis extracted solution. The propolis extraction solution in an amount of 586 g is mixed with saponin in 100 g, lecithin in 45 g and polyglycerol fatty acid ester in 197 g and they are stirred and emulsified to obtain clear and water-soluble propolis solution. Two grams of this water-soluble propolis solution is mixed with 10 g of sugar powder and the mixture is dried in a dryer.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Adaptive expertise is the ability to apply existing skills to novel situations. Adaptive expertise enables physicians to reduce preventable medical errors when managing clinical scenarios not encountered during training. However, residency curricula rarely address this learning outcome. Error Management Training improves transfer of skills to new contexts and develops adaptive expertise. Although this methodology has been shown to improve adaptive expertise in procedural skills, its impact on cognitive skills in medical training remains underexplored. Error Management Training promises to improve patient care by developing emergency physicians' adaptive expertise. However, the investigators need further evidence for its efficacy with cognitive skills in residency training. The investigators aim to demonstrate that Error Management Training improves adaptive expertise in a cognitive skill, using head computed tomography interpretation as a model.
AIM: To develop a radiomics signature applied to magnetic resonance imaging (MRI)-images to predict cytogenetic abnormalities in multiple myeloma (MM).
MATERIALS AND METHODS: Patients with newly diagnosed MM were enrolled retrospectively from March 2019 to September 2022. They were categorised into the high-risk cytogenetics (HRC) group and standard-risk cytogenetics (SRC) group. The patients were allocated randomly at a ratio of 7:3 into training and validation cohorts. Volumes of interest (VOI) was drawn manually on fat suppression T2-weighted imaging (FS-T2WI) and copied to the same location of the T1-weighted imaging (T1WI) sequence. Radiomics features were extracted from two sequences and selected by reproducibility and redundant analysis. The least absolute shrinkage selection operation (LASSO) algorithm was applied to build the radiomics signatures. The performance of the radiomics signatures to distinguish HRC with SRC was evaluated by ROC curves. The area under the curve (AUC), specificity, and sensitivity were also calculated.
RESULTS: A total of 105 MM patients were enrolled in this study. The four and 11 most significant and relevant features were selected separately from T1WI and FS-T2WI sequences to build the radiomics signatures based on the training cohort. Compared to the T1WI sequence, the radiomics signature based on the FS-T2WI sequence achieved better performance with AUCs of 0.896 and 0.729 in the training and validation cohorts respectively. A sensitivity of 0.833, specificity of 0.667, and Youden index of 0.500 were achieved for the FS-T2WI radiomics signature in the validation cohort.
CONCLUSIONS: The radiomics signature based on MRI provides a non-invasive and convenient tool to predict cytogenetic abnormalities in MM patients.
The invention comprises sulphonamides of the formula <FORM:1004582/C2/1> in which (a) R1 is hydrogen and R2 is a halogen atom or a methyl group or (b) R1 is a halogen atom or a methyl group and R2 is hydrogen or a halogen atom.  The invention comprises also salts of the sulphonamides.  The compounds may be prepared by reacting 3,4-dichlorobenzene sulphonic acid chloride with an appropriately substituted aniline at atmospheric temperature in an aqueous medium in the presence of an acid-binding agent or in a non-polar organic solvent.  The examples describe the preparation of the 3- and 4-chloranilide, the m- and p-toluidide, the 3-methyl-4-bromanilide and the 4-bromanilide of 3,4-dichlorobenzene sulphoric acid.  The products are useful as bacteriostats and fungistats (see Division A5).ALSO:Bacteriostats and fungistats for medicinal or veterinary use contain sulphonamides of the formula <FORM:1004582/A5-A6/1> in which (a) R1 is hydrogen and R2 is a halogen atom or a methyl group or (b) R1 is a halogen atom or a methyl group and R2 is hydrogen or a halogen atom (see Division C2). Salts of the sulphonamides may also be used.  Specified compounds are the 3- and 4-chloranilide, the m- and p-toluidide, the 3-methyl-4-brom-anilide and the 4-bromanilide of 3, 4-dichlorobenzene sulphonic acid.  The products may be formulated as compositions for oral, parenteral or topical use and may be put up as tablets, coated pills, suspensions, solutions, granules, capsules, emulsions, powders and ointments with the aid of known pharmaceutical diluents.  Other pharmaceutical products may be included in the compositions.
Part 1: Part 1A: Single dose administered in the morning on Day 1 under fasted conditions. Part 1B: Single dose administered in the morning of Day 1 under fed conditions.
The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions. A priority GENOPROFILE is measured and directs the customization of a subsequent nutraceutical to act as a therapeutic modality. Specifically the treatment includes slow attenuation of the pain medication by incorporating orals (shakes, liquid beverages, pills, tablets, troche, ointments etc.), Intramuscular, Intravenous, intra-rectal and any form necessary to deliver a sufficient amount of an anti-craving and anti-stress nutraceutical. Moreover, the invention includes examples of novel analgesic ointments coupling Synaptamine and such analgesic and other anesthetic compounds including but not limited to Gabapentin, Ketamine, Baclofen, Ketoprofen, Amitriptyline, Lidocaine, Cyclobenzapine, Diclofenac, Menthol, Camphor and Capsaicin. The GENOPROFILE will be used to determine pain sensitivity Intolerance.
The present invention discloses a hydrogel eye-care mask comprising medical marine organism components, which comprises a backing layer, a hydrogel layer and an anti-sticky layer. The backing layer is prepared by pharmaceutical-grade non-woven fabrics. The hydrogel layer comprises the following components in mass part: 0.1-0.5 part of carbomer, 0.03-0.06 part of carboxymethyl chitosan, 0.01-0.1 part of plant essential oil, 0.01-0.03 part of peppermint oil, 0.01-0.03 part of borneol, 8-10 parts of propylene glycol, 3-5 parts of alcohol, 0.4-0.6 part of polyvinylpyrrolidone, 0.4-0.6 part of carboxymethylcellulose sodium, 0.1-0.2 part of disodium ethylene diamine tetraacetate, and 0.08-0.12 part of sodium benzoate. The anti-sticky layer is prepared by PC release paper. According to the technical scheme of the invention, the carbomer is adopted as the main gel skeleton of the hydrogel eye-care mask. Meanwhile, the carboxymethyl chitosan having the bacteriostasis effect is added, and the plant essential oil, the peppermint oil, the borneol and other components are added at the same time to prepare the hydrogel layer. Therefore, the hydrogel eye-care mask is capable of relieving the eye fatigue.
Gemcitabine : 1000/m2 will be administered on days 1 and 8 at every 3 weeks . TS-1 will be administered orally according to body surface area (BSA) as follows : BSA\<1.25 M2, 80 mg/day; 1.25 M2≤BSA\<1.5 M2, 100 mg/day; 1.5 M2≤BSA, 120 mg/day for 14 consecutive days followed by a 7-day rest.
Depression and injection drug use often come hand-in-hand. This is especially true in populations with limited access to mental health care and with a high risk of illness and HIV transmission. Depressed injection drug users in these populations usually continue their drug use for extended periods of time, thereby further promoting the spread of HIV. This cycle has created a significant public health problem. It is necessary to explore new approaches to facilitate and maintain long-term behavior changes within this population. This study will evaluate the effectiveness of treatment with antidepressant medications in reducing HIV risk behaviors in depressed intravenous drug users.

Participants in this open label study will be randomly assigned to receive either antidepressant treatment or no treatment. Participants in the treatment group will meet with a psychiatrist monthly for 12 months. Based on psychiatric evaluations and participants' medical histories, doctors will prescribe an appropriate antidepressant medication or a combination of medications. Participants in the treatment group may also receive referrals for other services if necessary. Participants assigned to receive no treatment will be contacted at Months 3 and 9 to verify their contact information; they will also receive any necessary referrals. All participants will partake in interviews at baseline and Months 6 and 12 to assess changes in HIV risk behavior and depressive symptoms.
PROBLEM TO BE SOLVED: To provide ultrasonic diagnostic equipment comprising plural report writing parts, capable of preventing plural kinds of different inspection reports, corresponding to a same inspection.SOLUTION: Report writing parts 32, 58 limit writing of duplicated inspection reports, for each inspection. When a report writing start instruction is given by a user on ultrasonic diagnostic equipment 10, the report writing part 32 is started up. For example, observation or the like is input to the inspection report by the user. When the user instructs a report writing finishing, the report writing part 32 writes the inspection report indicating contents at the time point of the instruction. When the inspection is finished, the inspection report is automatically sent to a work station 50. When the inspection report is not written at inspection finishing time, the report writing part 32 automatically writes the inspection report. At this time, the inspection report is automatically sent to the work station 50.SELECTED DRAWING: Figure 1
Acute fractures around the hip are prevalent injuries associated with potentially devastating outcomes. The growing utilization of arthroplasty for femoral neck fractures in the elderly is likely a result of improvements in reoperation rates and postoperative function. Compared to hemiarthroplasty, total hip arthroplasty is associated with a slight functional benefit that is unlikely noticeable for many patients, as well as minimal differences in complications and patient reported outcome measures. However, the evidence supporting cement use in femoral stem fixation is robust. Multiple high power randomized controlled trial-based studies indicate cement fixation brings more predictable outcomes and fewer reoperations. In the setting of acute acetabular fracture, total hip arthroplasty is a favorable approach for elderly patients and fracture patterns associated with increased risk of revision after open reduction and internal fixation. Variations in patient characteristics and fracture patterns demand careful consideration whenever selecting the optimal treatment. In fracture patient populations, comanagement is an important consideration when seeking to reduce complications and promote cost-effective quality care.
Abstract Systems and methods for purification and concentration of autologous alpha-2-macroglobulin (A2M) from whole blood are provided. Also provided are diagnostic methods for identifying sites in the synovial joints, spine, tendons or ligaments for treatment of pain, degeneration, or inflammation with autologous A2M. Methods for utilizing autologous A2M in combination with other autologous treatments (e.g. platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M  and/or to prolong the half life of the protein in joints and spine disc or epidural space. Date Recue/Date Received 2020-10-02
Mindfulness Meditation Training (MMT) has been used successfully to decrease stress, pain, and adverse health symptoms in a varied subject population. MMT has been described as "paying attention in a particular way." Although attention is a key component of meditation, little is known about the cognitive and neural changes within the human attention system that result from MMT. In this study, we examine the effects of MMT on the human attention system using neurobehavioral measures. Here MMT comprises participation in a Mindfulness-Based-Stress-Reduction (MBSR) course, while the comparison group participates in a nutrition education course, both 8 weeks long. We compare the performance and neural activity of these groups both before and after participation in the course.
OBJECTIVE: Hyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was to comprehensively describe the biologic characteristics (including genetic background) of clinically defined hyperuricemia subtypes in two large geographically independent gout cohorts.
METHODS: Hyperuricemia subtype was defined as renal uric acid overload (ROL), renal uric acid underexcretion (RUE), combined, or renal normal. Twenty single nucleotide polymorphisms (SNPs) previously identified as gout risk loci or associated with serum urate (SU) concentration in the East Asian population were genotyped. Weighted polygenic risk scores were calculated to assess the cumulative effect of genetic risks on the subtypes.
RESULTS: Of the 4,873 participants, 8.8% had an ROL subtype, 60.9% RUE subtype, 23.1% combined subtype, and 7.2% normal subtype. The ROL subtype was independently associated with older age at onset, lower SU, tophi, and diabetes mellitus; RUE was associated with lower body mass index (BMI) and non-diabetes mellitus; the combined subtype was associated with younger age at onset, higher BMI, SU, estimated glomerular filtration rate (eGFR), and smoking; and the normal subtype was independently associated with older age at onset, lower SU, and eGFR. Thirteen SNPs were associated with gout with 6 shared loci and subtype-dependent risk loci patterns. High polygenic risk scores were associated with ROL subtype (odds ratio [OR] = 9.63, 95% confidence interval [95% CI] 4.53-15.12), RUE subtype (OR = 2.18, 95% CI 1.57-3.03), and combined subtype (OR = 6.32, 95% CI 4.22-9.48) compared with low polygenic risk scores.
CONCLUSION: Hyperuricemia subtypes classified according to renal uric acid handling have subtype-specific clinical and genetic features, suggesting subtype-unique pathophysiologic mechanisms.
The purpose of the research is to establish whether body composition and body image perception are affected throughout the different phases of the menstrual cycle and if the perception can be modified through resistance training. To the best of our knowledge, only one study has analyzed the effects of the menstrual cycle on body image perception. However, research analyzing the effects of the menstrual cycle on both body image perception and, body composition is lacking. Furthermore, research in the effects of resistance training on menstrual cycle-related changes on both perceived and measured body composition are inexistent. Findings from this study have the potential to increase the knowledge about resistance training's effects in modulating body image perception throughout the menstrual cycle. Further understanding of these responses may set the groundwork to develop exercise intervention programs to reduce the risk of developing more serious mental conditions linked to unhealthy body image perception.
The first cohort will be administered 40 mg once daily (q.d). The second cohort will be administered 40 mg twice daily (b.i.d). The third cohort will be administered 40 mg three times daily (t.i.d).
Albumin is distributed throughout the extracellular space and more than 60% of the body albumin pool is located in the extravascular fluid compartment. Albumin has a circulating life span of 15-20 days, with a turnover of approximately 15 g per day. The balance between synthesis and breakdown is normally achieved by feedback regulation. Elimination is predominantly intracellular and due to lysosome proteases.

In healthy subjects, less than 10% of infused albumin leaves the intravascular compartment during the first 2 hours following infusion. There is considerable individual variation in the effect of albumin on plasma volume.

In some patients, the plasma volume can remain elevated for several hours. In critically ill patients, however, albumin can leak out of the vascular space in substantial amounts at an unpredictable rate.
Individuals in this condition will take part in a single 15-25 minute session focused on reducing health vulnerabilities in one of four areas: diet, exercise, sleep, or stress. This condition is designed to control for the effects of active interaction with a clinicians (e.g. common factors). As with the experimental condition, this session will utilize a motivational interviewing framework.