anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Approximately 500,000 infants are born prematurely in the United States every year. Premature birth prior to 27 weeks gestation currently accounts for approximately 40% of infant mortality within the United States. When compared to full term infants, premature infants have a higher risk of physical or cognitive impairment and prematurity care accounts for over 26 billion dollars annually. Parents of premature infants are placed under significant emotional, financial, and personal stress. However, parental education about prematurity is often not evidenced based, varies significantly between OB and Neonatology providers, and lacks educational aids to help parents comprehend the information provided.

Several medical societies (American Academy of Pediatrics (AAP), American Congress of Obstetrics and Gynecology (ACOG), National Institute of Child Health and Human Development (NICHD)) and parental advocates have voiced concern that the current practice is sub-optimal. Several studies have looked at this challenging situation from the family's perspective and have shown that parents find this counseling to be helpful but rarely reassuring and often stressful. Cognitive science research has recommended the use of multimedia information to simultaneously use both text and visual cognitive channels to improve information uptake and retention. Policy statements from the AAP, ACOG, and NICHD have all emphasized the importance of improving the prenatal counseling process to give our parents the most information possible so that they can make the best choices possible for their vulnerable infant.

Potential study participants will be identified after hospitalization at Froedtert Hospital for premature labor. As per current clinical practice all mothers and their support person will have a neonatology consult requested by the obstetrician. These potential participants will be screened for eligibility in the study. Mothers and their support person will then be consented for participation and will be randomized to receive either verbal counseling with printed gestational age handout or verbal counseling with the multimedia information regarding prematurity. Participation of the pregnant woman's support person will be allowed by not required. If both mother and support person consent to participate, the support person will be will be assigned the same group as the mother. Participants will take a baseline STAI (State-Trait Anxiety Inventory) at time of randomization. After prenatal counseling has been completed by a neonatal provider (neonatology attending or fellow) the participants will be provided the validated questionnaire (previously developed) to assess their knowledge of prematurity based on the AAP recommended information for parents anticipating a premature birth. Participants will also retake the STAI.
INTRODUCTION: Laparoscopic fundoplication remains the standard treatment for patients with severe gastro-oesophageal reflux disease (GORD). Multiple randomised controlled trials (RCTs) have compared the two most commonly performed surgical techniques, total and posterior partial fundoplication (Nissen [NF] and Toupet [TF]), in terms of symptom control and treatment failure in patients without subsequent dysmotility disorders. We aimed to conduct a systematic review and meta-analysis of these two techniques with regard to the long-term effect on reflux control and associated dysphagia.
METHODS: The MEDLINE®, Embase®, PubMed® and Cochrane Library databases were searched, and all the relevant published RCTs were shortlisted according to the inclusion criteria. The summated outcomes of long-term results relating to the recurrence of GORD and dysphagia were evaluated in a meta-analysis using RevMan software.
RESULTS: Eight studies (all RCTs) on 1,545 patients undergoing NF or TF were eligible for inclusion in this meta-analysis. There were 799 patients in the NF group and 746 in the TF group. In the random effects model analysis, the incidence of long-term recurrence of GORD was not statistically different between the NF and TF cohorts (odds ratio [OR]: 0.69, 95% confidence interval [CI]: 0.34-1.41, z=1.01, p=0.31). However, the incidence of long-term dysphagia was statistically lower in the TF group (OR: 2.92, 95% CI: 1.49-5.72, z=3.13, p=0.002) with low between-study heterogeneity (I2=0%).
CONCLUSIONS: The findings of this systematic review and meta-analysis on symptomatic GORD appear to be in favour of partial posterior fundoplication (TF) as the optimal treatment. It provides equivalent outcomes in reflux symptom control with a lower risk of postoperative dysphagia compared with total fundoplication (NF).
An herbal composition reducing inflammation in bones and joints by inhibiting the enzyme cyclooxygenase-2 is prepared from holy basil, turmeric, ginger, green tea, rosemary, huzhang, Chinese goldthread, barberry, oregano and  scutellariae baicalensis . More particularly, the herbal composition of the present invention contains therapeutically effective amounts of the supercritical extracts of ginger, rosemary and oregano, and therapeutically effective amounts of extracts of holy basil, turmeric, green tea, huzhang, Chinese goldthread, barberry, rosemary and  scutellariae baicalensis . The herbal composition can be administered orally, topically or parenterally. Particularly preferred embodiments are soft gel capsules for oral administration and creams for topical application. In addition to reducing inflammation, the herbal composition also promotes healthy joint function and, because it inhibits cyclooxygenase-2 (COX-2), the composition also promotes normal cell growth. Furthermore, the herbal composition contains organic anti-aging constituents that inactivate oxygen free radicals, thereby providing antioxidant benefits in addition to anti-inflammatory benefits.
Participants will continue to take the study drug they were taking in the parent study, B/F/TAF. Participants who are diagnosed with HIV-1 infection in parent study CO-US-380-5578 and complete the study drug will continue to take the study drug they were taking in the parent study, B/F/TAF. The dose of B/F/TAF will be based on the weight of the participant.
A pharmaceutical composition having antitumour activity and consisting of certain mutually synergistic para-substituted phenols. The composition is prepared, within certain quantitative limits, from the following six para-substituted phenols: 0-95 % gamma-L-glutaminyl-4-hydroxybenzene (GHB), 0-90 % hydroquinone, 0-90 % methol, 0-60 % amidol, 0-90 % paracetamol and 0-85 % N,N-1,4-diethyl-phenylenediamine. The composition is formulated according to the desired therapeutical use such that one composition may contain fewer components, although GHB is present in all the compositions. The composition may be administered orally, parenterally or in an intracavitary manner. As the composition has no major toxic effects and no leucopenic activity, extended and repeated courses of treatment are possible, whereby excellent therapeutic results may often be achieved. The composition has synergistic activity with respect to cytostatic agents, reversers and ionising radiation therapy, so combining the novel composition with conventional therapy leads to substantially enhanced results.
Poliosis is defined as the absence of melanin in hair, and hair graying typically occurs with hair melanin reduction. Poliosis can occur at any age but presents in childhood in certain genetic and acquired conditions, with many families seeking evaluation from a pediatric dermatologist. Poliosis presents as white hair typically restricted to a certain location of the scalp. Children may also present with a reduction of expected hair pigmentation, referred to as pigment dilution, or the development of hair graying. This review aims to provide a streamlined diagnostic approach for pediatric dermatologists when presented with these hair findings. Poliosis should be recognized as a potential diagnostic feature or initial sign in many syndromes and thus can guide clinicians in diagnosing and managing conditions earlier in a patient's care. Since many of the genetic and acquired conditions that present with poliosis or hair pigment dilution have extracutaneous manifestations, early diagnosis is vital in establishing multidisciplinary care.
Ground-glass nodules (GGNs) are generally considered an early stage of lung cancer. The imaging characteristics and curative efficacy of multiple GGNs as metastases remain unclear. Microsatellite instability-high (MSI-H) is a biomarker for immunotherapy. The therapeutic effect and prognosis for patients with MSI-H and Epidermal Growth Factor Receptor (EGFR)-sensitive mutation stays uncertain. Here, we report a case of a lung adenocarcinoma patient presenting with ground-glass metastases, MSI-H, and EGFR-sensitive mutation and provide clinical data on the efficacy and prognosis. We describe the predictive significance of carcinoembryonic antigen (CEA) for disease progression when there is inconsistency between treatment effectiveness and CEA changes.
RFID-enabled medical devices and related systems are disclosed herein that include an RFID transmitter configured to provide an interrogation signal that impinges on an RFID tag associated with the medical device to trigger a response signal. The response signal may indicate the presence or absence of a medical device in proximity to the RFID transmitter. A console communicatively coupled to the RFID transmitter may determine, record, and analyze procedure or usage information about the medical device. Further information about the medical device may be encoded within the response signal and provided to the console. The console settings may be automatically updated based on information in the response signal. Additional modes are also contemplated, including optical image recognition of the medical device kit. In addition, the AR viewer may provide image overlays to guide the user through the correct procedure. Program compliance may be automatically recorded and monitored.
Study 205013 is a Phase 1 FTIH study of GSK3145095 alone and in combination with other anticancer agents including pembrolizumab in subjects with pancreatic ductal adenocarcinoma (PDAC) and other selected tumors. The study includes up to 4 parts: Part 1 dose escalation will be conducted in approximately 30 adult subjects with advanced or metastatic PDAC using escalating doses of GSK3145095 as monotherapy only. Part 2 will combine escalating doses of GSK3145095 with 200 milligram (mg) pembrolizumab. Dose escalation of GSK3145095 will begin at least one level below the highest dose shown to have an acceptable toxicity profile in at least 3 subjects in Part 1. Part 2 may be conducted in a broader population of selected solid tumors using a combination of escalating doses of GSK3145095 and 200 mg pembrolizumab. Part 3 will enroll subjects treated with one or more dose levels of GSK3145095 in combination with 200 mg pembrolizumab. Part 4 will investigate the combination of additional anticancer agents with one or more doses of GSK3145095 identified as safe in Part 1. Up to approximately 220 subjects will be treated in the study. Parts 1 and 2 will each treat up to approximately 30 subjects. Parts 3 and 4 will treat up to approximately 160 subjects (up to 80 subjects in each Part). The total duration of the study is expected to last up to 2 years.
PURPOSE: To obtain an oral cavity composition containing alumina trihydrate as a polishing cleaner. CONSTITUTION: This composition is obtained by formulating 20-70wt.% of nonabrasive precipitated alumina trihydrate having 3-15μm particle size with 0.1-2wt.% of sodium monofluorophosphate, 0.02-5wt.% of a water-soluble zinc compound (e.g. zinc citrate), a humectant, a surfactant, a binder, a thickening agent, a perfume, etc., and preparing. The composition is prepared as a dentifrice in a creamy or gelatinous state. The stability of monofluorophosphate in the dentifrice is improved and compatibility with the soluble zinc is bettered by using the nonabrasive precipitated alumina abradant. Zinc citrate as the soluble zinc has inhibitory action on tartar and dental plaque.
The Da Vinci single port® (SP) robotic platform heralds a new era of minimally invasive surgery (MIS). The primary objective of this study was to assess short-term outcomes in patients undergoing SP robotic hysterectomy with concomitant sacrocolpopexy for pelvic organ prolapse (POP). We performed a retrospective case series at two tertiary care centers between January 2021 and August 2023. Patients with POP electing to undergo SP robotic hysterectomy with concomitant sacrocolpopexy were included. Chart abstraction was used to collect patient demographics and clinical outcomes. Recurrent POP was defined as new bothersome vaginal bulge symptoms and evidence of POP beyond the hymen on postoperative examination. 69 patients were included. Median operative time was 209 min (135-312) and estimated blood loss was 100 mL (20-2000). 1 (1.4%) patient sustained a major vascular injury resulting in laparotomy. Median pain score and morphine equivalents administered in PACU were low at 3 (0-7) and 3.2 (0-27) respectively. At 3 months, 60 (86.9%) patients were seen either in person or via telemedicine for their follow up appointment. 59/60 (98.3%) reported no vaginal bulge symptoms and 50/51 (98.0%) had stage 0 or 1 prolapse on exam. One (1.4%) patient had recurrent prolapse and underwent an additional repair. Postoperative complications included 2 (2.9%) cases of ileus/small bowel obstruction, 1 (1.4%) pelvic hematoma requiring a blood transfusion, and 1 (1.4%) umbilical hernia. The SP robotic platform is a safe and feasible platform for MIS hysterectomy and sacrocolpopexy with good short term anatomic and symptomatic outcomes.
Coronavirus 19 (Covid-19) emerged as a global pandemic with over 12,900 deaths in Israel alone. On average, more than 40,000 tests to detect the virus daily were performed in Israel. According to the US Centers for Disease Control and Prevention (CDC), the recommended methods for testing are nasopharyngeal swab, mid-turbinate, or anterior nasal swab specimen. Although these methods are generally safe, they are not without risks. Particularly, traumatic or improperly angled test may injure the skull base and lead to a cerebrospinal fluid leak. This rare condition presents with headache, unilateral nasal discharge with a metallic taste, and is aggravated when bending forward. It is essential to recognize this condition since there is an increased risk of meningitis, brain abscess, sepsis, and death. In addition, one should know how to perform nasal swab tests to avoid this complication. This paper presents a case of a five-year-old girl diagnosed with cerebrospinal fluid rhinorrhea following a nasal swab test for Covid-19. In addition, a summary of the clinical, radiological and treatment aspects was prepared.
Adopting a healthy dietary pattern may be an initial step in combating inflammation-related chronic diseases; however, a comprehensive synthesis evaluating current evidence is lacking. This umbrella review aimed to summarise the current evidence on the effects of dietary patterns on circulating C-reactive protein (CRP) levels in adults. We conducted an exhaustive search of the Pubmed, Scopus and Epistemonikos databases, spanning from their inception to November 2023, to identify systematic reviews and meta-analyses across all study designs. Subsequently, we employed a random-effects model to recompute the pooled mean difference. Methodological quality was assessed using the A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2) checklist, and evidence certainty was categorised as non-significant, weak, suggestive, highly suggestive or convincing (PROSPERO: CRD42023484917). We included twenty-seven articles with thirty meta-analyses of seven dietary patterns, fifteen of which (50 %) exhibited high methodological quality. The summary effects of randomised controlled trials (RCT) found that the Mediterranean diet was the most effective in reducing circulating CRP levels, followed by Vegetarian/Vegan and Energy-restricted diets, though the evidence was of weak quality. In contrast, Intermittent Fasting, Ketogenic, Nordic and Paleolithic diets did not show an inverse correlation with circulating CRP levels. Some results from combined interventional and observational studies, as well as solely observational studies, also agreed with these findings. These dietary patterns show the potential in reducing CRP levels in adults, yet the lack of high-quality evidence suggests future studies may alter the summary estimates. Therefore, further well-conducted studies are warranted.
The study aimed at evaluating how sires, classified for their additive genetic effects on residual feed intake (RFI) of ad libitum-fed progeny, influence growth performance, tissue accretion, and gain composition in restricted-fed offspring (96-168 kg body weight, BW). A total of 416 purebred C21 Goland pigs, offspring of 23 sires, were randomly allocated to three feeding groups: ad libitum, restricted medium-protein, or restricted low-protein. Empty BW, body lipid mass and body protein mass were estimated from individual BW and backfat measures using literature equations. Residuals of a linear regression of average daily feed intake on average empty BW, body lipid and protein daily gains were used as estimates of individual RFI in ad libitum-fed pigs. Additive genetic effects of sires on RFI of ad libitum-fed pigs were estimated with a linear animal model and solutions of the model were used to allocate the sires to low- (LRFI), medium- (MRFI), or high-RFI (HRFI) groups. Restricted-fed progeny of LRFI sires exhibited reduced average daily feed intake (-3%) compared to MRFI and HRFI progeny. This indicates that LRFI progeny make a more efficient use of energy intake and implies that variation in RFI across families, assessed under ad libitum feeding, is related to the across-family variation in feed efficiency detected under restricted feeding. LRFI progeny exhibited also a lower feed conversion ratio (-11%), partially resulting from of a 3% increase in growth rate compared with HRFI. Thus, LRFI progeny consumed less feed, while growing at a similar or slightly higher rate than MRFI or HRFI. No significant differences across sire classes were observed for daily tissue accretion and gain composition. Hence, we can hypothesise that efficient sires would not affect carcass leanness of heavy pig progeny fed restricted.
5% Dextrose and Electrolyte No. 48 Injection (Multiple Electrolytes and Dextrose Injection, Type 1, USP) has value as a source of water, electrolytes and calories. They are capable of inducing diuresis depending on the clinical condition of the patient.

5% Dextrose and Electrolyte No. 48 Injection (Multiple Electrolytes and Dextrose Injection, Type 1, USP) produce a metabolic alkalinizing effect. Lactate ions are metabolized ultimately to carbon dioxide and water, which requires the consumption of hydrogen cations.
Lynch syndrome (LS) is the most common inherited colorectal cancer syndrome, and results from germline mutations in mismatch repair genes that confer a high lifetime risk of colorectal cancer (CRC) (60 to 70%). Most CRCs arise from asymptomatic polyps. Development of such polyps into cancer can be prevented if polyps are detected early by endoscopy and removed. Colonoscopy is proposed every 2 years in LS patients more than 25 years old, and every year when colonic neoplasia has been detected. Efficient chemoprevention has the potential to represent a cost-effective intervention in these patients and could allow a delay in colonoscopic surveillance.

Several epidemiological studies have shown that regular use of low dose aspirin (75 to 300 mg/d) is associated with a 20 to 30 % reduction in the risk of sporadic colonic polyps and CRC. Four randomised controlled trials (RCT) have also shown a decrease in colorectal polyp recurrence. In a pooled analysis of cardio-vascular prevention RCTs, as well as in a meta-analysis, daily aspirin was associated with a reduced risk of CRC and CRC associated mortality. Aspirin preventive benefit is expected to outweigh its putative side effects in high risk patients. The CAPP2 study in Lynch syndrome patients showed that aspirin (300 mg x2/d) did not reduce significantly the risk of colorectal neoplasia after 29 months, but an extended follow-up (mean 56 months) showed a reduction in colorectal cancer in the aspirin group. In this study, the endoscopic follow-up was not optimal with a relatively low detection rate of colorectal neoplasia according to usual reported rate when chromo-endoscopy is performed. So, the real effect and clinical benefit of aspirin are still to be characterised in Lynch syndrome patients.
1315424 Producing semi-synthetic penicillins ALFA FARMACEUTICI SpA 8 Nov 1971 [7 Nov 1970] 51807/71 Heading C2A A process for producing penicillins of Formula I wherein R is an α-aminobenzyl group, an α- carboxybenzyl group, a 2- or 3-thienylmethyl group, a 2- or 3-thienylaminomethyl group or an isoxazole group of Formula III in which R 1  is phenyl, 2-chlorophenyl or 2,6-dichlorophenyl or R is a group of Formula IV wherein R 2  is aryl, aryloxy or arylmercaptyl which may optionally be substituted with one or more halogen atoms, R 3  is hydrogen, an alkyl group having one to ten carbon atoms, an amino group or a monoalkyl or dialkylamino group wherein the alkyl moieties have from 1 to 6 carbon atoms, a carboxyl group, a carboxyalkyl group wherein the alkyl moiety has from 1 to 8 carbon atoms, a carboxymethylacetoxy group or a carboxybenzyl group, or R 2  and R 3  together form a cycloaliphatic ring having 5 to 7 carbon atoms, R 4  is an amino group or a monoalkyl or dialkylamino group wherein the alkyl moieties have from 1 to 6 carbon atoms and non-toxic salts and esters thereof, comprises the enzymatic dephenylacetylation of a diacylpenicillin of Formula II by means of penicillin acylase. The dephenylacetylation may be carried out at a temperature of from 30‹ to 42‹ C. at a pH of from 7À5 to 8À0. The penicillin acylase used may be produced by a micro-organism of the genus Alternatia, Aspergillus, Botritis, Cephalosporium, Cryptococcus, Emericellopsis, Eipcoccum, Epiolermophyton, Fusarium, Mucor, Penicillum, Phoma, Trichoderma, Trichophyton, Trichosporon, Streptomyces, Aerobacter Alcaligenes, Bordetella, Cellulomonas, Corynebacterium, Erwinia, Escherichia, Flavobacterium, Micrococcus, Proteus, Pseudomonas, Salmonella, Sarcina, Xantomonas, Torulopsis, Rhodotorula or Arthrobacter. Specific strains which may be used include Escherichia coli and Aerobacter aerogenes. Penicillins which may be produced by this process include oxacillin, cloxacillin, dicloxacillin, ampicillin, phenethicillin and methicillin. Reference has been directed by the Comptroller to Specification 922,278, 978,229, 1,004,670, 1,017,615 and 1,227,042.