anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
ETHNOPHARMACOLOGICAL RELEVANCE: The clinical efficacy of the Yiqi Kaimi prescription has been confirmed in slow transit constipation. However, the effects and biological mechanism of Yiqi Kaimi prescription are still unclear.
AIMS OF THE STUDY: To identify the effects of Yiqi Kaimi prescription on intestinal motility; To reveal the potential key targets and pathways of Yiqi Kaimi prescription for the treatment of slow transit constipation.
MATERIALS AND METHODS: The effects of Yiqi Kaimi prescription on slow transit constipation were investigated in a mouse model. The terminal ink propulsion experiment and fecal indocyanine green imaging was used to measure the intestinal transit time. Protein phosphorylation changes in colon tissues treated with Yiqi Kaimi prescription were detected using a Phospho Explorer antibody microarray. Bioinformatic analyses were performed using the Database for Annotation Visualization and Integrated Discovery (DAVID) and the Search Tool for the Retrieval of Interacting Genes (STRING). Western blot analysis and immunohistochemistry confirmed the observed changes in phosphorylation.
RESULT: s: Yiqi Kaimi prescription significantly increased the intestinal transit rate (P < 0.05 vs. model) and reduced the time to first discharge of feces containing fecal indocyanine green imaging in mice (P < 0.05 vs. model). The administration of Yiqi Kaimi prescription induced phosphorylation changes in 41 proteins, with 9 upregulated proteins and 32 downregulated proteins. Functional classification of the phosphorylated proteins with DAVID revealed that the critical biological processes included tyrosine protein kinases, positive regulation of calcium-mediated signaling and response to muscle stretch. The phosphorylation of the spleen tyrosine kinase (SYK) at Tyr348 increased 2.19-fold, which was the most significant change. The phosphorylation level of the transcription factor p65 (RELA) at Thr505 was decreased 0.57-fold. SYK was a hub protein in the protein-protein interaction network and SYK and RELA formed the core of the secondary subnetwork. The key protein phosphorylation after treatment with Yiqi Kaimi prescription were verified by Western blot analysis and immunohistochemistry.
CONCLUSION: Yiqi Kaimi prescription significantly enhanced intestinal motility. This effect was attributed to alterations in the phosphorylation levels of various target proteins. The observed changes in protein phosphorylation, including SYK and RELA, may serve as crucial factors in the treatment of slow transit constipation.
FIELD: biotechnology. SUBSTANCE: invention relates to agents used for prophylaxis and treatment of pathological processes in medicine and veterinary science, namely to suppurative-inflammatory diseases, gastroenteritis and colitis of different etiology, dysbacteriosis, food allergy. One liter of liquid sporobacterin contains: viable cells of the strain Bacillus subtilis 534 deposited in All-Union collection of microorganisms of Institute of biochemistry and physiology of microorganisms of AS USSR at = 1666 D, 10 7 -10 15  CFU/ml; sodium chloride, 30-250 g; distilled water, up to 1 l. Microorganisms of hay bacillus in sodium chloride solution retain viability and even tendency to moderate growth. Except for, such composite of the preparation prevents to pollution by foreign microflora and enhances curative effectiveness. Liquid form of sporobacterin is more suitable in using. EFFECT: valuable medicinal properties of preparation. 9 ex
PURPOSE:To make a titled capsule easily soluble in hot water by coating powder on the microcapsules produced by a coacervation method without hardening the same or without hardening thoroughly the same and drying the coated capsules. CONSTITUTION:Powder such as wheat flour is coated as a coating agent for preventing sticking on the microcapsules produced by a coacervation method at the amt. corresponding to 10-250% of the weight of the capsules without hardening the capsules or without hardening thoroughly the same, whereafter the capsules are dried. The powder for peventing sticking to be used is one kind among starch, solid powdered fats, celluloses, protein powder, inorg. salt powder, powder of org. acids and the salts thereof, powder of amino acids and the salts thereof, cane sugar, etc. or their combinations as powder for food. The microcapsules produced by the coacervation method which are heretofore not used so much in food are made easily soluble in water or hot water and are produced inexpensively.
Methods are provided for selecting parental plants having disease resistance and for using these plants in breeding programs. In one method of the invention, lesion mimic mutants are screened for either resistance to a pathogen of interest or for the expression of systemic acquired resistance (SAR) genes. Such mutants having the desired traits or expressing the desired genes are then used in breeding programs. Parent plants can also be selected based on the constitutive expression of SAR genes. These mutants are phenotypically normal yet exhibit a significant level of disease resistance. Also disclosed are plant mutants that do not express systemic acquired resistance genes even when induced by a pathogen and methods of use for such mutants.
Pencillin salts which are stable and active are prepared by converting penicillin into its salt with an inorganic base under substantially anhydrous conditions.  The preferred salt is the ammonium salt, and the preferred way of preparing the salt is to dissolve the free pencillin in an organic solvent and to add the inorganic basic substance.  In the case of the ammonium salt free dry ammonia is passed through the solution, in this case the dry ammonium salt will precipitate.  If desired the precipitation may be repeated to obtain a purer product.  Moreover the solution to be used for precipitation of the salts may be pre-purified by reextracting the solution in an organic solvent with a buffer solution whereby the active principle goes into the aqueous buffer solution, which is then acidified and re-extracted with organic solvents.  Other preliminary purification methods such as treatment with fuller's earth may also be used.  In examples: (1) Culture fluid is extracted with chloroform, reextracted with a phosphate buffer, acidified and re-extracted with chloroform.  Dry ammonia gas is passed in to the dried chloroform solution and the precipitated salt filtered.  (2) The chloroform solution obtained by extraction of the culture fluid is diluted with petroleum ether, the precipitate centrifuged, dissolved in benzene, extracted with a phosphate buffer and treated as in example (1). (3) Culture fluid is extracted with chloroform as in examples (1) and (2).  The chloroform solution is dried and treated with sodium bicarbonate and filtered.  The filtrate is treated with magnesium oxide which is separated, decomposed with sulphuric acid and the solution so obtained extracted with chloroform.  The extract is diluted with benzene and the ammonium salt formed by passing in ammonia gas.  The Specification as open to inspection under Sect 91 includes also a process for the extraction of penicillin from a pencillin culture fluid by treatment of the fluid with chloroform and the extraction of the penicillin from the chloroform.  The invention disclosed in the Specification as open to inspection is also stated to comprise in general the production of highly purified concentrates of the anti-bacterial principle or principles of moulds, and particularly of moulds of the penicillin group.  The extraction of the penicillin from the chloroform is preferably carried out by adding thereto an aliphatic hydrocarbon such as petroleum ether to precipitate the penicillin.  An additional feature of the extraction process is that of adding ammonium sulphate to the culture fluid to aid in the extraction of the penicillin.  It is also stated that the ammonium sulphate may, if desired be replaced by practically any soluble salt such as sodium chloride or ammonium chloride.  The process of forming salts of penicillin extends also to the use of organic bases, of which b -naphthylamine is specified.  An additional example is also included.  This subject-matter does not appear in the Specification as accepted.
Our study aimed to investigate the effects of an enhanced recovery after surgery (ERAS) nursing program on surgical site wound infections (SSWI) and postoperative complications in patients undergoing laparoscopic hepatectomy (LH) for hepatocellular carcinoma. Computer searches of the PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure and Wanfang databases were conducted to gather randomised controlled trials (RCTs) that were published from inception to September 2023. The target studies evaluated the effects of the ERAS nursing program in patients undergoing LH for hepatocellular carcinoma. Two independent authors screened the literature, extracted the data and performed quality assessments. Dichotomous variables were analysed using odds ratios (ORs) and 95% confidence intervals (CIs), as effect analysis statistics. Stata software (version 17.0) was used for data analysis. Eleven RCTs with 765 patients were included, with 383 patients in the ERAS group and 382 in the control group. The results revealed that the incidence of SSWI (OR = 0.32, 95%CI:0.15-0.71, p = 0.004) and postoperative complications (OR = 0.23, 95%CI:0.15-0.34, p < 0.001) were both significantly reduced in the ERAS group, compared with the control group. The ERAS nursing program, when applied to patients undergoing laparoscopic hepatic cancer resection, can effectively reduce the incidence of SSWI and postoperative complications, thus promoting postoperative recovery.
Participants will take part in a community building program in which Cherokee cultural, linguistic, and historical experts will met with the self-selected community groups approximately 1 x month for 5 months. Participants will complete homework assignments for each meeting and will complete a final presentation on the history and culture of their families and communities.
FIELD: cosmetics. SUBSTANCE: shampoo contains detergent basis and odorant and also, additionally, thickening stabilizer in the form of diethanolamide from vegetable oils, 40% lactic acid, genuine honey, edible salt, sodium styrene as opalescence agent, preservative, and lactoserum. Detergent basis is a surfactant with 68-73% of weight fraction of active substance. Liquid surfactant has 30-40% of active substance in the form of aminobetaines. Shampoo also contains L. caprifolium as odorant. All components are taken in specified proportions. Product shows high therapeutic and prophylactic effect and prevents dandruff. EFFECT: improved foaming characteristics providing washing and degreasing effects. 1 tbl
The invention discloses a producing method of a cosmetic skin lotion produced by pear juice and glycerin in proportion through mixing and sterilization. According to the record of a practical Chinese herbal medicine cyclopedia, the pear juice can be used for washing and spreading on faces to beautify features and serves as a natural cosmetic. The glycerin can moisturize skins, retain water and absorb moisture from the air. Skins look full and glossy only through full moisture nourishment. The pear juice and the glycerin are combined to achieve the effect of beautifying and moisturizing. The production method includes subjecting a snow pear to washing, juice squeezing and filtering, mixing with the glycerin, and performing bottling and sterilization to obtain the lotion, wherein the ratio of the snow pear and the glycerin is 1:1. Because preservatives are not added, only 30-40g of the cosmetic skin lotion can be filled into each bottle, and the lotion can be used up within 7-10 days after decapped because the pear juice contains sugars and is easy to ferment and deteriorate after decapped. If preservatives which have no effects on skins are added, 50g or more can be filled into each bottle, and the service life can be prolonged. The cosmetic skin lotion is easy to produce, low in price, free of toxic and side effects, and capable of being accepted by vast consumers easily; and raw materials are easy to obtain.
FIELD: medicine. SUBSTANCE: method involves taking central lymph sample in the amount of 1000-2000 ml from III-IV phase ovarian carcinoma patients in the presurgical and/or antitumor treatment period. The lymph is divided into two equal portions. One portion is incubated during 30-60 min with cytostatic agents at a dose of cyclophopsphane 500 mg/m 2 , adriablastine 40 mg/m 2 , cis-platinum 100 mg/m 2  and intravenously administered by dripping at the same day on the background of hyperhydrataion, forced diuresis, antiemetic therapy. The other lymph portion is incubated with 2 mln units of Roncoleykine during 24 h at 37 C in complete culturing medium. Washing from the culturing medium is carried out and intravenously administered by dripping at the second day after carrying out chemotherapy treatment. EFFECT: enhanced effectiveness in reducing tumor propagation process scale, the number of metastases and tumor size. 2 tbl
A device and method for therapeutical treatment of disorders in the oral cavity and a process for manufacturing of said device is disclosed. The device comprises a nitric oxide (NO) eluting polymer. The nitric oxide (NO) eluting polymer is configured to elute a therapeutic dosage of nitric oxide (NO) when used in the oral cavity. The device allows for target treatment of infections or wounds in the oral cavity. The device comprising the nitric oxide (NO) eluting polymer is arranged to contact an infected area in the oral cavity, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO).
Vitamin D has been shown as an important marker of prognosis in a variety of clinical settings, including overall mortality, acute respiratory distress syndrome (ARDS), infection/sepsis, asthma, cardiovascular disease, diabetes, and pediatric/medical/surgical intensive care unit outcomes. Vitamin D not only plays a role in bone maintenance, but also a variety of extra-axial functions including immune-dysregulation and systemic inflammation. In addition, a number of randomized clinical trials support the supplementation of vitamin D as improving outcome in critical care patients. While the evaluation of vitamin D levels remains a standard-of-care at our institution, the widespread use of vitamin D monitoring and impact on neurocritical care patients remains limited. The investigators' recent prospective observational study of vitamin D levels in neurocritical patients showed that deficiency (\<20ng/dL) was highly associated with prolonged hospital stay and increased in-hospital mortality for emergent patients. Moreover, a number of limitations arise from this study due to its observational nature. This study proposes a randomized, double-blinded, placebo-controlled, single center evaluation of vitamin D supplementation in the neurocritical care patient population. Patients admitted to the neurocritical care unit for emergent cases and with vitamin D deficiency (\<20ng/dL) will undergo vitamin D serum draw on admission and be randomized to receive cholecalciferol/vitamin D3 supplementation (540,000 IU once orally) or placebo. The primary outcome measured will be hospital length-of-stay. Secondary outcomes will include length of ICU course, complications, medication adverse events, discharge Glasgow Outcome Score, in-hospital and 30-day mortality, as well as quality-of-life. Power analysis estimates 198 patients will be needed for each subgroup to determine a 2 day difference in length-of-stay, and the study plans to recruit 218 patients per treatment arm to account for dropout, which will take approximately 6-9 months to recruit. Interim analysis and safety monitoring will be performed. The investigators hypothesize that vitamin D supplementation may make a significant impact on reducing morbidity and mortality in the neurocritical care population. The possibility of reducing hospital length of stay and mortality from a simple, safe, and cost-effective intervention such as vitamin D supplementation may be a useful adjuvant treatment in the neurocritical care population.
OBJECTIVE: To (i) investigate the goals and expectations of participants enrolled in a clinical trial of physiotherapist-led treatment for femoroacetabular impingement (FAI) syndrome and (ii) explore associations between their expectations and self-reported hip burden and kinesiophobia. METHODS: Data from 150 participants with FAI syndrome who participated in a clinical trial were analysed. Participants described their most important treatment goal and the expectation of achieving this goal throughout physiotherapy treatment. The International Hip Outcome Tool (iHOT-33) subscales were used to assess self-reported hip burden. The Tampa Scale for Kinesiophobia was used to assess kinesiophobia. Participants goals were qualitatively analysed using content analysis. Linear regression was used to explore associations between patient expectations and iHOT and Tampa Scale for Kinesiophobia scores. RESULTS: Participants with FAI syndrome reported goals relating to exercise (52%), improving activities of daily living quality (23%), improving physical function (15%), and reducing pain (10%). Negative expectations regarding physiotherapist-led treatment were reported by 68% of participants. Those with negative expectations reported worse scores for the iHOT-Total score (mean difference = 12 points, 95%CI = [4 to 19]), and iHOT-Symptoms (14 points, [7 to 21]) and iHOT-Social (11 points, [2 to 21]) subscales compared to those with positive expectations. Treatment expectations were not associated with iHOT-Sport, iHOT-Job, and Tampa Scale for Kinesiophobia scores (p > 0.05). CONCLUSION: Patients with FAI syndrome had a generally negative expectation of physiotherapist-led treatment. There was a mismatch between patients' goals and current treatment approaches. Participants with FAI syndrome and negative expectations reported worse quality of life, symptoms, and social concerns than those with positive expectations.
Many pathogenetic mechanisms have been proposed for amyotrophic lateral sclerosis (ALS). Recently, there have been emerging suggestions of a possible role for the gut microbiota. Gut microbiota have a range of functions and could influence ALS by several mechanisms. Here, we review the possible role of gut-derived neurotoxins/excitotoxins. We review the evidence of gut symptoms and gut dysbiosis in ALS. We then examine a possible role for gut-derived toxins by reviewing the evidence that these molecules are toxic to the central nervous system, evidence of their association with ALS, the existence of biochemical pathways by which these molecules could be produced by the gut microbiota and existence of mechanisms of transport from the gut to the blood and brain. We then present evidence that there are increased levels of these toxins in the blood of some ALS patients. We review the effects of therapies that attempt to alter the gut microbiota or ameliorate the biochemical effects of gut toxins. It is possible that gut dysbiosis contributes to elevated levels of toxins and that these could potentially contribute to ALS pathogenesis, but more work is required.
A Modified Vaccinia Virus Ankara adapted for growing in a Vero cell line (Vero-MVA) obtained by a process comprising the following steps: a) infecting cells of the Vero cell line with a wild-type MVA; b) harvesting of the viruses produced from cells; and optionally c) infecting fresh cells of the Vero cell line with the newly produced viruses and harvesting the virus produced from the said cell.  This is repeated until the virus is adapted to growing in the cells. A method for producing a nucleic acid sequence, peptide and/or polypeptide, comprising: a) infection of a host cell with the recombinant Vero-MVA; b) cultivation of the infected host cell under suitable conditions; and optionally c) isolation and/or enrichment of the nucleic acid sequence, peptide and/or protein produced by said host cell. The Modified Vaccinia Virus Ankara (MVA) have a strongly reduced virulence for most mammals, especially humans.  The adapted MVA can be used e.g. for parenteral immunization, as a vector system, or in the active or inactivated from as an adjuvant or as a regulator of the unspecific components of the immune system.
OBJECTIVE: The main objective of this study was to analyse the prevalence and characteristics of subclinical GCA in patients with PMR.
METHODS: This was a cross-sectional multicentre international study of consecutive patients with newly diagnosed PMR without symptoms or signs suggestive of GCA. All patients underwent US of the temporal superficial, common carotid, subclavian and axillary arteries. Patients with halo signs in at least one examined artery were considered to have subclinical GCA. The clinical, demographic and laboratory characteristics of the PMR group without subclinical vasculitis were compared with subclinical GCA, and the pattern of vessel involvement was compared with that of a classical single-centre GCA cohort.
RESULTS: We included 346 PMR patients, 267 (77.2%) without subclinical GCA and 79 (22.8%) with subclinical GCA. The PMR patients with subclinical GCA were significantly older, had a longer duration of morning stiffness and more frequently reported hip pain than PMR without subclinical GCA. PMR with subclinical GCA showed a predominant extracranial large vessel pattern of vasculitic involvement compared with classical GCA, where the cranial phenotype predominated. The patients with PMR in the classical GCA group showed a pattern of vessel involvement similar to classical GCA without PMR but different from PMR with subclinical involvement.
CONCLUSION: More than a fifth of the pure PMR patients had US findings consistent with subclinical GCA. This specific subset of patients showed a predilection for extracranial artery involvement. The optimal screening strategy to assess the presence of vasculitis in PMR remains to be determined.
BACKGROUND: Evidence regarding the impact of nurse staffing on the health outcomes of older adult patients with cancer is scarce. Therefore, this study aimed to evaluate the impact of nurse staffing on long-term and short-term mortality in elderly lung cancer patients.
METHODS: This study analyzed data from 5,832 patients with lung cancer in Korea from 2008 to 2018. Nursing grade was considered to assess the effect of nursing staff on mortality in older adult patients with lung cancer. The Cox proportional hazards model was used to evaluate the effect of the initial treatment hospital's nursing grade on one- and five-year mortality. Additionally, economic status and treatment type of patients were analyzed.
RESULTS: Approximately 31% of older adult patients with lung cancer died within one year post-diagnosis. Patients in hospitals with superior nursing grades (lower nurse-to-bed ratios) exhibited lower mortality rates. Hospitals with nursing grades 2 and 3 exhibited approximately 1.242-1.289 times higher mortality than grade 1 hospitals. Further, the lower the nursing grade (higher nurse-to-bed ratio), the higher the five-year mortality rate.
CONCLUSION: Both short- and long-term mortality rates for older adult patients with lung cancer increased at inferior nursing grades. Treatment in hospitals having inferior nursing grades, upon initial hospitalization, may yield better outcomes. This study provides valuable insight into the quality of adequate staffing to improve the quality of care for elderly cancer patients.