anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Following the conclusion of SAD groups and after sufficient review of study data and approval by the SRC, a third set of healthy adult subjects will participate in the Food Effect cohort. Subjects will be randomized to Fed or Fasted on Days 1 and 12. Follow up visits will occur 7 days post Day 12 dose.
The present disclosure relates to a comprehensive patient biological information collection device (CPBICD). Each patient carries one CPBICD. The CPBICD uses a set of patient biological information collection sensors to collect and monitor patient's biological information constantly. In certain embodiments, CPBICD is used to monitor patients' wellbeing in an emergency response system. Biological information of each patient is collected and transmitted to CPBICD server for processing using artificial intelligence algorithms to detect early emergency signs before emergency occurs. When at least one of the patient biological information collection sensors detects certain type of biological information that exceeds a normal range of baseline biological information stored in the patient database, emergency response system determines the patient is near or in an emergency, and coordinates immediate medical assistance to the patient based on the patient information received and retrieved from the patient database.
Pediatric patients will undergo one MRI examination with gadopiclenol (V2). Gadopiclenol will be injected in a single intravenous (IV) bolus injection at a recommended rate of approximately 2 mL/second followed by a 0.9% saline flush via manual injection or power injector.
This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1) activity to the patient in need, including human patients. These methods do not require inhibition of fatty acid synthesis. In particular, this invention provides methods for development of therapeutics that selectively enhance fatty acid oxidation, increase energy production, and reduce adiposity while preserving lean mass, through the pharmacological stimulation of CPT-1 activity. In a preferred mode, the agent is administered in an amount sufficient to increase fatty acid oxidation. In another preferred mode, the agent is administered in an amount sufficient to antagonize malonyl CoA inhibition of CPT-1. In yet another preferred mode, the agent is administered in an amount sufficient to increase malonyl CoA level.
PURPOSE: To form the stripes of two different colors on a base material only by using small amounts of coloring materials by forming a first space between an insert and a tube, and forming a second space between a conical portion and a central cylinder in the insert. CONSTITUTION: A space (A) defined by a shoulder portion 18 of a tube, an upper tube wall 36 and a flange 30 is provided with a paste material of a first color. A space (B) defined by an inner surface of the flange 30, an outer surface of a central cylinder 22 and an inner surface of a truncated conical portion 28 is provided with a paste material of a second color. A space (C) inside W the tube 10 is filled with a basic paste material. When the tube 10 is squeezed, the paste material in the space (C) is filled into an upper part of the central cylinder 22 and extended through an outlet hole 16. Simultaneously the paste material in the space (A) receives the force in the direction of an arrow X to be directed into the guide grooves 24b, 24d for forming the surface stripes on the basic paste material. Simultaneously the paste material in the space (B) is also enters the grooves 24a, 24c for forming the surface stripes.
Patients in this arm only received Cognitive Behavioral Therapy (CBT). Six, 60 minute weekly sessions were followed by 4 bi-weekly sessions and 3 monthly booster sessions.
Abstract A pesticide for delivering a physical mode of action kill comprising an active ingredient, a surfactant, a co-solvent and a diluent. The active ingredient comprises xanthan gum in a concentration of from about 0.10 wt. % to about 1.0 wt. % based on the total weight of said pesticide. The surfactant is selected from the group consisting of hydrocarbons, ethers, phenols, glycols, lactones, chlorinated hydrocarbons, aromatic hydrocarbons, nitrated hydrocarbons, dibasic esters, mono-esters such as ethyl acetate, butyl acetate, ethyl-3-ethoxy-propionate, propylene glycol propanediol, propylene glycol butyl ether acetate, dipropylene glycol methyl ether acetate, tetrahydrofurfuryl alcohol and combinations thereof. The diluent comprises water. The xanthan gum is in the form of a micelle in a colloid suspension, and has a weight average molecular weight of about 10,000 to 25,000,000 and is present in an amount sufficient to cause a physical mode of action kill in insects. C REPRESENTATION OF POLYSACCHARIDE CHAINS IN COLLOIDAL - SPRAY DROPLET -- - -ENCAPSULATING A - WHITEFLY NYMPH
1322671 Globulin antibody antivenin fractions ABBOTT LABORATORIES 18 June 1971 [22 June 1970] 28805/71 Heading A5B A globulin antibody antivenin fraction is isolated by precipitating a globulin antibody antivenin fraction from clarified serum obtained from a hyperimmunized host by the addition of ethanol, suspending the resulting precipitate in a physiologically isotonic aqueous solution having a pH of at least 4.7 but less than neutral at a temperature of 1‹C. or less, removing insoluble material therefrom and adding ethanol to the solute until precipitation of said globulin antibody antivenin is complete. The finally precipitated globulin antibody antivenin may be, whilst still moist, redissolved in an aqueous phosphate buffered saline of neutral pH optionally containing a preservative and a stabiliser. Preferably each volume of clarified serum is diluted with from 1 to 3 volumes of water, the pH adjusted to from 7.4 to 7.8 and the resulting solution aged at a temperature of 1‹C. or less for 12 hours prior to the initial precipitation with ethanol. The resulting precipitate may be suspended in the isotonic solution in a concentration of from 0.5% to 1.0% by weight. The suspended buffered solution may be lyophilized.
PURPOSE:To obtain a hydroxyl radical scavenger useful as a treating agent of diseases caused by hydroxyl radical and the protection and preservation of organs by using nicorandil or its salt as an active component. CONSTITUTION:The objective scavenger capable of effectively eliminating hydroxyl radical in living body without exerting adverse effect on the living body is produced by using N-(2-hydroxyethyl)-nicotinic acid amide nitrate ester (nicorandil) or its salt as an active component. The diseases caused by hydroxyl radical are e.g. malignant tumor, radiation damage, inflammation, rheumatism, ulcer of digestive organs and pulmonary edema. The agent is preferably administered in the form of an injection to enable the rapid increase of the nicorandil concentration in blood. Preferably, an injection having a nicorandil concentration of 10<-9>-10<-2>M (especially 10<-5>-10<-3>M) is administered at a rate of 1-20ml/h (especially 4-6ml/h).
Participants will attend two in-clinic sessions per week with either a licensed Physical Therapist or Exercise Physiologist and complete three sessions per week independently outside of the clinic. Each session will be 1 hour in duration, 5 days a week for 8 weeks, for a total of 40 hours. The stretching exercises are designed not to increase heart rate or have excessive head motion consist of static stretching and yoga based movements.
INTRODUCTION: Surgical site infection (SSI) poses a substantial postoperative challenge, affecting patient recovery and healthcare costs. While surgical wound irrigation is pivotal in SSI reduction, consensus on the optimal method remains elusive. We developed a novel device for surgical wound irrigation and conducted preclinical and clinical evaluations to evaluate its efficacy and safety.
METHODS: Two preclinical experiments using swine were performed. In the washability test, two contaminated wound model were established, and the cleansing rate between the device and the conventional method were compared. In the contamination test, the irrigation procedure with a fluorescent solution assessed the surrounding contamination of drapes. Subsequently, a clinical trial involving patients undergoing abdominal surgery was conducted.
RESULTS: The washability test demonstrated significantly higher cleansing rates with the device method (86.4% and 82.5%) compared to the conventional method (65.2% and 65.1%) in two contamination models. The contamination test revealed a smaller contaminated region with the device method than the conventional method. In the clinical trial involving 17 abdominal surgery cases, no superficial SSIs or adverse events related to device use were observed.
CONCLUSIONS: Our newly developed device exhibits potential for achieving more effective and safe SSI control compared to conventional wound irrigation.
BACKGROUND: The optimal multimorbidity measures for predicting disability trajectories are not universally agreed upon. We developed a multimorbidity index among middle-aged and older community-dwelling Chinese adults and compare its predictive ability of disability trajectories with other multimorbidity measures.
METHODS: This study included 17,649 participants aged ≥50 years from the China Health and Retirement Longitudinal Survey 2011-2018. Two disability trajectory groups were estimated using the total disability score differences calculated between each follow-up visit and baseline. A weighted index was constructed using logistic regression models for disability trajectories based on the training set (70 %). The index and the condition count were used, along with the pattern identified by the latent class analysis to measure multimorbidity at baseline. Logistic regression models were used in the training set to examine associations between each multimorbidity measure and disability trajectories. C-statistics, integrated discrimination improvements, and net reclassification indices were applied to compare the performance of different multimorbidity measures in predicting disability trajectories in the testing set (30 %).
RESULTS: In the newly developed multimorbidity index, the weights of the chronic conditions varied from 1.04 to 2.55. The multimorbidity index had a higher predictive performance than the condition count. The condition count performed better than the multimorbidity pattern in predicting disability trajectories.
LIMITATION: Self-reported chronic conditions.
CONCLUSIONS: The multimorbidity index may be considered an ideal measurement in predicting disability trajectories among middle-aged and older community-dwelling Chinese adults. The condition count is also suggested due to its simplicity and superior predictive performance.
Standard care and twice-daily nebulised HTS (MucoClear 6%, PARI Pharma). Participants will be instructed to administer a 1 x 4 mL ampoule twice daily for 52 weeks using the eFlow rapid nebuliser and eTrack controller (PARI Pharma).
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ ID NO. 3 or SEQ ID NO.5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
The invention discloses a traditional Chinese medicine transdermal agent for treating prostate diseases and a preparation method thereof. The traditional Chinese medicine transdermal agent is prepared from an emulsion matrix and a transdermal absorption enhancer, wherein the mass ratio of the emulsion matrix to the transdermal absorption enhancer is 18:1. The emulsion matrix is prepared from traditional Chinese medicine extract liquor and emulsion raw materials in the mass ratio of 11:4. The traditional Chinese medicine extract liquor is prepared from, by weight, 90-110 parts of flos carthami, 290-310 parts of spreading hedyotis herb, 90-110 parts of radix rehmanniae, 70-80 parts of divaricate serpentroot herb and roots, 70-80 parts of Aquilegia viridiflora Pall, 50-60 parts of herba pogostemonis, 50-60 parts of Parameria lagvigata(Juss)Moldenke, 40-48 parts of Deeringia amaranthoides Merr, 40-45 parts of Youngia stenoma Ledeb, 32-40 parts of flowers of Meconopsis quintuplinervia, 30-35 parts of Elatostema cyrtandrifolium, 25-30 parts of Boraginaceae and 25-30 parts of Cremanthodium angustifolium. The technological process is short, and the cost is low. The traditional Chinese medicine transdermal agent has the multiple effects of clearing away heat and toxic materials, inducing diuresis for removing edema, tonifying the kidneys and soothing the nerves and the like.
Prodn. of variant parasite strains of reduced infectivity comprises treating, in vitro, a virulent protozoal strain with at least one chemical mutagen so as to form clones. The pref. parasites are Trypanosoma cruzi, T.rhodesiense, T.gambiense, T.brucei, T.vivax, T.congolense, Leishmania donovani, L. tropica and Plasmodium falciparum and the mutagens are N-methyl-N'-nitro-N-nitrosoguanidine (I), ethyl methanesulphonate and-or N-methyl-N-nitrosourea. Also new are the variant parasite strains thermselves and live or killed vaccines contg. them. These clones have intact viability but reduced infectivity and are not derived from mouse tumours and are the known variants of reduced infectivity.
PURPOSE:To obtain a capsule which discharges little core substance and has excellent shelf stability and solubility characteristics and used as the capsule for an aromatizing agent by using polyvinyl alcohol having the specified mean degree of polymerization and the mean degree of saponification for a microcapsule wall involved with a hydrophobic substance. CONSTITUTION:Polyvinyl alcohol having 700-1,300 mean degree of polymerization and 75-95% mean degree of saponification is used as an essential agent for a microcapsule wall involved with a hydrophobic substance. As a result, the release of a core substance is made little and the storage for a long period is enabled by protecting safely the microcapsule wall and its handling is made easy. Therefore a volatile substance such as a perfume and the agricultural chemicals and a fertilizer can be utilized as the core substance. Furthermore since the dissolving velocity of a capsule film in the period of the use is quick and it horelly remain the aq. soln. introduced with the capsule is not polluted.
BACKGROUND/OBJECTIVES: Capsinoids are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, this study aimed to investigate the effects of capsinoids on adiposity and biomarkers of cardiac oxidative stress in obese rats induced by a high-fat diet.
METHODS: Male Wistar rats were exposed to a high-fat diet for 27 consecutive weeks. After the characterization of obesity (week 19), some of the obese animals began to receive capsinoids (10 mg/kg/day) by orogastric gavage. Adiposity and comorbidities were assessed. In the heart, remodeling, injury, and biomarkers of oxidative stress were determined.
RESULTS: The treatment did not reduce obesity-induced adiposity but was efficient in reducing cholesterol levels. Capsinoid treatment did not cause a difference in heart and LV mass, despite having reduced troponin I concentrations. Furthermore, capsinoids did not reduce the increase in the advanced oxidation of protein products and carbonylated proteins caused by obesity in cardiac tissue. In addition, obese rats treated with capsinoids presented high levels of malondialdehyde and greater antioxidant enzyme activity compared to untreated obese rats.
CONCLUSIONS: In conclusion, treatment with capsinoids increases antioxidative enzyme activity and prevents obesity-induced cardiac injury without positively modulating body fat accumulation and cardiac oxidative biomarkers.
Acetaminophen (APAP) is the most commonly used over-the-counter medication throughout the world. At therapeutic doses, APAP has potent analgesic and antipyretic effects. The efficacy and safety of APAP are influenced by multifactorial processes dependent upon dosing, namely frequency and total dose. APAP poisoning by repeated ingestion of supratherapeutic doses, depletes glutathione stores in the liver and other organs capable of metabolic bioactivation, leading to hepatocellular death due to exhausted antioxidant defenses. Numerous genes, encompassing transcription factors and signaling pathways, have been identified as playing pivotal roles in APAP toxicity, with the liver being the primary organ studied due to its central role in APAP metabolism and injury. Nuclear factor erythroid 2-related factor 2 (NRF2) and its array of downstream responsive genes are crucial in counteracting APAP toxicity. NRF2, along with its negative regulator Kelch-like ECH-associated protein 1, plays a vital role in regulating intracellular redox homeostasis. This regulation is significant in modulating the oxidative stress, inflammation, and hepatocellular death induced by APAP. In this review, we provide an updated overview of the mechanisms through which NRF2 activation and signaling critically influence the threshold for developing APAP toxicity. We also describe how genetically modified rodent models for NRF2 and related genes have been pivotal in underscoring the significance of this antioxidant response pathway. While NRF2 is a primary focus, the article comprehensively explores other genetic factors involved in phase I and phase II metabolism of APAP, inflammation, oxidative stress, and related pathways that contribute to APAP toxicity, thereby providing a holistic understanding of the genetic landscape influencing susceptibility to this condition. SIGNIFICANCE STATEMENT: This review summarizes the genetic elements and signaling pathways underlying APAP-induced liver toxicity, focusing on the crucial protective role of the transcription factor NRF2. This review also delves into the genetic intricacies influencing APAP safety and potential liver harm. It also emphasizes the need for deeper insight into the molecular mechanisms of hepatotoxicity, especially the interplay of NRF2 with other pathways.
Esophageal atresia (EA) is a defect of the embryogenesis of the laryngotracheal tube. There are isolated forms of EA and combinations with a tracheoesophageal fistula (TPF). Esophageal plastic surgery with an isoperistaltic transplant from the transverse colon was performed in children with EA. After this surgical intervention children require observation in the intensive care unit (ICU). During this period, infusion therapy satisfies physiological needs and compensates for physiological and pathological losses. However, it is not always possible to compensate for the body's fluid needs and maintain a normovolemic state. Thus, fluid overload develops. It is based on a pathophysiological process when severe operational stress leads to the damage of glycocalyx in the vascular wall. As a result, albumin freely passes into the interstitium, and oncotic pressure rises in tissues. Fluid overload in the intra- and postoperative period can be a factor in an unfavorable outcome, leading to organ damage, as well as death.
Systems, methods, and other embodiments associated with a personal user dashboard are described. In one embodiment, a method includes extracting, from one or more databases, case processing information about adverse events processed by a group of users. The one or more databases store data about a plurality of adverse events processed by the group of users. The example method may also include calculating metrics using the case processing information. The metrics are performance indicators about processing of the plurality of adverse events by the group of users. The method includes displaying, on a graphical user interface (GUI), user metrics for a user of the group of users. The user metrics are displayed by filtering confidential data from the metrics. The access privileges of the user are limited to a user level access to prevent access to group level data.
A tele-health solution promotes patient wellness and reduces healthcare costs while improving patient compliance. To qualify for home oxygen or CPAP machines, a user must monitor their blood oxygen saturation (SpO 2 ), typically overnight. A DME provider is often used to provide the monitoring equipment, retrieve the monitoring equipment and get the data obtained to the physician. A system is discloses that allow the data obtained to be sent wirelessly, for example, via general packet radio service or the like, to a computer server that can generate the necessary report and electronic submit such report to the physician. This process can take minutes, rather than days. Moreover, the pulse oximeter can be outfitted with a good study indicator which monitors the time that data has been successfully measured by the device, allowing a determination of whether the data is adequate or if the device needs to be worn for another night.
The recommended daily dosage of REYATAZ for pediatric patients (6 to less than 18 years of age) is based on body weight and should not exceed the recommended adult dosage. REYATAZ Capsules must be taken with food. The data are insufficient to recommend dosing of REYATAZ for any of the following: (1) patients less than 6 years of age, (2) without ritonavir in any pediatric patient less than 13 years of age, and (3) patients less than 40 kg receiving concomitant tenofovir, H2-receptor antagonists, or proton-pump inhibitors. 

The recommended dosage of REYATAZ with ritonavir in pediatric patients at least 6 years of age is shown in Table 2.

For treatment-naive patients at least 13 years of age and at least 40 kg, who are unable to tolerate ritonavir, the recommended dose is REYATAZ 400 mg (without ritonavir) once daily with food. For patients at least 13 years of age and at least 40 kg receiving concomitant tenofovir, H2-receptor antagonists, or proton-pump inhibitors, REYATAZ should not be administered without ritonavir.
AIMS: Understanding the mechanisms underlying ascending aortic dilation is imperative for refined risk stratification of these patients, particularly among incidentally identified patients, most commonly presenting with tricuspid valves. The aim of this study was to explore associations between ascending aortic haemodynamics, assessed using four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR), and circulating biomarkers in aortic dilation.
METHODS AND RESULTS: Forty-seven cases with aortic dilation (diameter ≥ 40 mm) and 50 sex-and age-matched controls (diameter < 40 mm), all with tricuspid aortic valves, underwent 4D flow CMR and venous blood sampling. Associations between flow displacement, wall shear stress (WSS), and oscillatory shear index in the ascending aorta derived from 4D flow CMR, and biomarkers including interleukin-6, collagen type I α1 chain, metalloproteinases (MMPs), and inhibitors of MMPs derived from blood plasma, were investigated. Cases with dilation exhibited lower peak systolic WSS, higher flow displacement, and higher mean oscillatory shear index compared with controls without dilation. No significant differences in biomarkers were observed between the groups. Correlations between haemodynamics and biomarkers were observed, particularly between maximum time-averaged WSS and interleukin-6 (r = 0.539, P < 0.001), and maximum oscillatory shear index and collagen type I α1 chain (r = -0.575, P < 0.001 in cases).
CONCLUSION: Significant associations were discovered between 4D flow CMR derived whole-cardiac cycle WSS and circulating biomarkers representing inflammation and collagen synthesis, suggesting an intricate interplay between haemodynamics and the processes of inflammation and collagen synthesis in patients with early aortic dilation and tricuspid aortic valves.