anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
As one of the most widely used medical devices, sutures face challenges related to surgical site infections (SSIs) and lack of subcutaneous traceability. In the present study, a facile and effective approach using peptide-AIE nanofibers (NFs-K18) to create fluorescent-traceable antimicrobial sutures, which have been applied to four commercially available sutures is developed. The functionalized sutures of PGAS-NFs-K18 and PGLAS-NFs-K18 exhibit fluorescence with excellent penetration from 4 mm chicken breasts. They also demonstrate remarkable stability after 24 h of white light illumination and threading through chicken breasts 10 times. These sutures efficiently generate ROS, resulting in significant suppression of four clinical bacteria, with the highest antimicrobial rate of ≈100%. Moreover, the sutures exhibit favorable hemocompatibility and biocompatibility. In vivo experiments demonstrate that the optimized PGLAS-NFs-K18 suture displays potent antimicrobial activity against MRSA, effectively inhibiting inflammation and promoting tissue healing in both skin wound and abdominal wall wound models, outperforming the commercially available Coated VICRYL Plus Antibacterial suture. Importantly, PGLAS-NFs-K18 exhibits sensitive subcutaneous traceability, allowing for accurate in situ monitoring of its degradation. It is believed that this straightforward strategy offers a new pathway for inhibiting SSIs and monitoring the status of sutures.
PURPOSE:To produce a large amt. of liposome by depositing a membrane forming lipid on a porous material and bringing the surface of the material into contact with an aq. soln. CONSTITUTION:A membrane forming lipid alone or its soln. in an org. solvent is injected into a device packed with a porous material to sufficiently impregnate the material, and the excess lipid is discharged outside the system. An inert gas such as nitrogen is passed through the device or the device is evacuated to remove the solvent, and the lipid is dried to solid. After the lipid is sufficiently dried, an aq. soln. is supplied and brought into contact with the dried lipid, and a dispersion of liposome in water is obtained. The dispersion is forcedly passed through the porous material repeately or vibrated by an ultrasonic wave or vibrator, hence the swelling of lipid and the separation of lipid from the porous material are promoted, and a large amt. of uniform liposome is efficiently produced.
BACKGROUND/AIM: Cervical cancer is the third leading cause of cancer-related death in women worldwide. Nearly all cases of cervical cancer are due to infection with human papillomavirus (HPV). Nowata110 has shown breakthrough therapeutic efficacy in phase II clinical study against plantar warts, with no reported side effects. This study evaluated the effectiveness of Nowarta110 in killing cultured HPV-transformed cancer cells and its anti-cancer effects in mice, using both vaginally engrafted and subcutaneously implanted animal cancer models.
MATERIALS AND METHODS: Nowata110 is a novel compound composed of colloidal silver and fig extract. The cytotoxic properties of Nowarta110 were evaluated on HPV-16 and HPV-18-transformed human cancer cells (ARPE-19/HPV-16 and HeLa cells, respectively). The therapeutic potential of Nowarta110 in vivo was evaluated following the engraftment of ME-180 epidermoid carcinoma cells in the mouse vagina or their subcutaneous implantation. Nowarta110 treatment was initiated when the tumor reached an approximate volume of 65 mm3 Results: Our data showed that HPV16-expressing human retinal pigmented epithelial cells are susceptible to Nowarta110-induced cell death, with a reduction in cell viability observed at 1% Nowarta110 and a complete absence of viable cells at 5% Nowarta110. In HPV18-expressing HeLa cells, Nowarta110 caused significant and rapid cell death at a dose of 5%, whereas lower doses of 1% did not produce the same effects. The results from animal studies indicated that Nowarta110 effectively induced tumor regression in both the intravaginal and subcutaneous tumor models.
CONCLUSION: Nowarta110 effectively induced cell death in HPV-16 and HPV-18-transformed human cancer cells. It also effectively induced tumor regression in mouse models with intravaginally engrafted or subcutaneously implanted cancer cells. Considering the high prevalence of HPV-induced cervical dysplasia and cancer and the lack of treatment, clinical studies to promote the implementation of Nowarta110 are warranted.
A method of suppressing bacteria that cause infections of the throat, sinuses, heart and arteries, and joints (arthritis) by delivering xylitol in a human mouth. The method is effective with troches of pure xylitol or with xylitol chewing gum or liquid, provided sufficient quantities of xylitol are delivered.  Streptococcus mutans  and  Staphylococcus aureus  in the blood are important contributors to plaque in arteries and on heart valves and bacterial arthritis. For people whose blood is not already infected with significant levels of these bacteria, every day use of xylitol sufficient to suppress these bacteria in the oral cavity will reduce their risk of subsequent cardiovascular disease, arthritis, and sinus infections. Strep throat is a common throat infection caused by  Streptococcus pyogenes . Frequent bathing with xylitol, such as from time release in the mouth, will speed recovery from strep throat.
Data about the incidence, optimal management and outcome of AOF is sparse. The largest national and international surveys report on less than 50 AOF. The latest worldwide survey was conducted in 2015 and managed to include 31 patients who developed AOF after atrial fibrillation ablation procedure. In the meanwhile, the total number of AF ablation procedures increased significantly. Additionally, AF ablation technology changes significantly with e.g. increasing numbers of cryoballoon ablation and contact force guided radiofrequency ablation.

The study is designed as a worldwide, multi-centre, anonymised registry study to evaluate the incidence, optimal management and outcome of this AOF. More than 50 patients with AOF following percutaneous catheter ablation will be included in the register.
Group A streptococcal (GrAS) infections are responsible for a wide spectrum of clinical syndromes, ranging from uncomplicated throat infections to life-threatening invasive infections. Some cases of uncomplicated and untreated pharyngitis may trigger the onset of acute rheumatic fever (ARF) accompanied by rheumatic heart disease (RHD). ARF is the most common cause of heart disease in children around the world and is associated with early morbidity and mortality. The most cost-effective method of preventing ARF and RHD would be vaccine prevention of the streptococcal infections that trigger the disease. Unfortunately, the overall burden of RHD in developing countries is unknown. This information is needed to adequately assess the potential risk- and cost-benefits of a GrAS vaccine that may eventually be introduced in countries where ARF and RHD are prevalent. The primary objective of this study is to determine the prevalence of RHD among children aged 5-15 in Leon. The secondary objective is to determine the sensitivity and specificity of clinical examination of the heart in an area of suspected high prevalence of RHD (Leon). This is an uncontrolled, observational, community-based study designed to provide detailed information about the prevalence of RHD in children in León, Nicaragua. Children and adolescents between the ages of 5 and 15 will be eligible for enrollment. Centro de Investigación en Demografía y Salud (CIDS - Center for Investigation of Demography and Health) staff will visit randomly selected dwellings with children between the target ages of 5 and 15 years, explain the nature and purpose of the study, and obtain signed informed consent from the parents or guardians of the children to collect demographic information. The study will also be discussed with all children 13 years of age or older, and their verbal agreement to participate in the study will be sought. After informed consent has been obtained and children are enrolled, CIDS staff will administer a questionnaire to capture the children's demographics. All enrolled children and their parent(s) from a given area will be offered transportation to the rheumatic heart disease clinic at HEODRA by van. CIDS staff will arrange the examinations and transportation and will inform the families appropriately. All children whose parent(s)/guardian provide informed consent will have at least one study visit at HEODRA. On the day of the scheduled clinic visit, the families will be informed again in detail about the RHD research study and written informed consent will again be obtained. All children who participate in the study will have an auscultation and a screening echocardiogram as part of the study. Those children who are identified by auscultation and/or by echocardiography to be in the "probable or possible rheumatic heart disease" groups will be asked to return for repeat echocardiography 6 months after their first examination. The primary and secondary endpoints of the study will be clinical diagnosis of RHD as confirmed by echocardiogram.
INTRODUCTION: The purpose of this study is to utilize a representative national sample to investigate the factors associated with margin positivity after attempted surgical resection. Given the changes in surgical approaches to lung cancer for the last 10 years, margin positivity and outcomes between robotic, video assisted thoracoscopic surgery (VATS) and open surgical resections may vary.
METHODS: This retrospective cohort study utilized the National Cancer Database. Patients with non-small-cell lung cancer, 18 or older and who had a surgical lung resection between 2010 and 2019 were included. Demographic data, along with patient-level clinical variables were extracted. Patient-level outcome variables including 30-day, 90-day mortality and readmission rates were analyzed. Univariable and multivariable logistic regression was utilized to assess factors associated with margin positivity.
RESULTS: A total of 226,884 patients were identified. Of the total cohort, 9229 had positive margins (4.2%). Patients with positive margins had statistically significant increased 30-day, 90-day mortality, as well as increased readmission rate. Older age, male sex, patients undergoing an open resection, patients who underwent a wedge resection, higher clinical stage, larger tumor size, squamous and adenosquamous histologies, and higher Charlson-Deyo Comorbidity Index were all associated with having a positive margin after resection.
CONCLUSION: In conclusion, there was no difference in margin positivity when comparing robotic and VATS resection, however, open resection had increased rates of margin positivity. Increasing tumor size, clinical stage, squamous and adenosquamous histologies, male sex, and patients undergoing a wedge resection were all associated with increased rates of margin positivity.
PURPOSE: DNA-dependent protein kinase (DNA-PK) plays a key role in the repair of DNA double strand breaks via nonhomologous end joining. Inhibition of DNA-PK can enhance the effect of DNA double strand break inducing anticancer therapies. Peposertib (formerly "M3814") is an orally administered, potent, and selective small molecule DNA-PK inhibitor that has demonstrated radiosensitizing and antitumor activity in xenograft models and was well-tolerated in monotherapy. This phase 1 trial (National Clinical Trial 02516813) investigated the maximum tolerated dose, recommended phase 2 dose (RP2D), safety, and tolerability of peposertib in combination with palliative radiation therapy (RT) in patients with thoracic or head and neck tumors (arm A) and of peposertib in combination with cisplatin and curative-intent RT in patients with squamous cell carcinoma of the head and neck (arm B).
METHODS AND MATERIALS: Patients received peposertib once daily in ascending dose cohorts as a tablet or capsule in combination with palliative RT (arm A) or in combination with intensity modulated curative-intent RT and cisplatin (arm B).
RESULTS: The most frequently observed treatment-emergent adverse events were radiation skin injury, fatigue, and nausea in arm A (n = 34) and stomatitis, nausea, radiation skin injury, and dysgeusia in arm B (n = 11). Based on evaluations of dose-limiting toxicities, tolerability, and pharmacokinetic data, RP2D for arm A was declared as 200 mg peposertib tablet once daily in combination with RT. In arm B (n = 11), 50 mg peposertib was declared tolerable in combination with curative-intent RT and cisplatin. However, enrollment was discontinued because of insufficient exposure at that dose, and the RP2D was not formally declared.
CONCLUSIONS: Peposertib in combination with palliative RT was well-tolerated up to doses of 200 mg once daily as tablet with each RT fraction. When combined with RT and cisplatin, a tolerable peposertib dose yielded insufficient exposure.
Pain occurs due to the intervertebral disc; ligaments in the region; or degeneration, strain, and sprains in the muscles, neurogenic, inflammatory, infectious, or neoplastic problems caused by structures in and around the spine . Low back pain is a serious health problem, with a lifetime prevalence of 84% . According to the American Society of Pain's clinical practice guidelines, low back pain is classified into three categories: nonspecific low back pain, radiculopathy-induced low back pain, and low back pain associated with another specific cause. A multidisciplinary approach is recommended for the treatment of low back pain. Before pharmacological treatments, cognitive behavioral therapy, physiotherapy exercise programmes, electrical physical therapy modalities, manual therapy, and psychological therapy are frequently referenced treatment options. Taping is one of the conservative physical therapy methods that is often a preferred treatment in clinics. Rigid (athletic) taping and kinesiological taping are the most preferred taping techniques . Non-elastic taping material is used in the rigid taping application. It is used to position soft tissue and ensure that the tissues come together, are protected from contact, create compression, and prevent local swelling. Studies supporting the sensorimotor and proprioceptive sensory enhancing effects of rigid tape, which provides very good sensory input over the skin, are found in previous studies \[7-9\]. Unlike rigid tape, kinesio tape can be stretched up to 140% of its resting length due to its structure, which is the approximate stretching capacity of normal skin .

Although there are various studies related to this topic, there is still no consensus on the effectiveness of taping in patients with low back pain who have disc degeneration. The reason for this is that some studies show the positive effect of kinesio taping on the reduction of low back pain, but some cannot show the effect of taping or find any changes . The healing mechanisms of different taping treatments have not been fully clarified. Moreover, local temperature, which is one of the indicators of vascularization and tissue healing, has not been investigated widely. Our study aims to examine the effects of different taping materials and techniques on pain, functionality, and local tissue temperature in patients with lumbar radiculopathy.
Subjects will receive LEE011 200 mg daily, in combination with everolimus 5 mg daily; in the setting of toxicity, everolimus dosing will be changed to 2.5 mg daily or 2.5 mg every other day. Subjects will continue treatment until meeting one of the criteria for removal from study.
A method of detecting and diagnosing cancers characterized by the presence of at least one nodule/neoplasm from an imaging scan is presented. To detect nodules in an imaging scan, a 3D CNN using a single feed forward pass of a single network is used. After detection, risk stratification is performed using a supervised or an unsupervised deep learning method to assist in characterizing the detected nodule/neoplasm as benign or malignant. The supervised learning method relies on a 3D CNN used with transfer learning and a graph regularized sparse MTL to determine malignancy. The unsupervised learning method uses clustering to generate labels after which label proportions are used with a novel algorithm to classify malignancy. The method assists radiologists in improving detection rates of lung nodules to facilitate early detection and minimizing errors in diagnosis.
PURPOSE:To improve the deodorizing power by suppressing the propagating of microorganisms which cause the generation of discomfortable odor by constituting the title agent from the water-soluble constituents contained in bamboo or the activated bamboo. CONSTITUTION:An absorptive/releasing liquid agent is made of bamboo or activated bamboo as raw material, and manufactured by extracting the water-soluble constituent. The bamboo as raw material may be raw bamboo or dried bamboo. In order to activate bamboo, steam boiling by the overheated steam having a temperature of 80-180 deg.C and a high pressure is carried out, and then the bamboo is dried and pulverized, and the produced powder is used. As the powdered substance of the activated bamboo, can be used the dry-distilled bamboo. Further, even in the case where the raw bamboo is used as raw material, the bamboo is pulverized or division-processed to form the small granules and used. When the water-soluble constituent is extracted, the air passing through an aero-magnetizer is introduced into water, and the powdered material of bamboo or the activated bamboo is immersed into the water, and the extracted liquid is obtained by filtering the solid portion.
In classical surgical circumcision, foreskin was hung up with the clamp. The outer skin and secondly the mucosa was cut by using scissors. Following the hemorrhage intervention, the skin-mucosa integrity was sutured by using the 5/0 absorbable suture. Medical dressing was done.
The aim of this study was to compare the operative parameters and complication rates between the umbilical (UMB) and right upper quadrant (RUQ) skin incisions for Ramstedt's pyloromyotomy for the treatment of infantile hypertrophic pyloric stenosis (IHPS). PubMed, EMBASE, Web of Science and Scopus databases were systematically searched. The studies where any one of the main outcomes of interest, i.e., operative time, wound infection rate, mucosal perforation rate were reported were eligible for inclusion. The statistical analysis was performed using a random-effects model. The methodological quality of the studies was assessed utilizing the Newcastle-Ottawa Scale. Fifteen studies comprising 2964 infants were included. As compared to the UMB group, the RUQ group showed a significantly lower mean operative time (p = 0.0004), wound infection rate (p < 0.0001) and mucosal perforation rate (p = 0.02). Although UMB incision produces an almost undetectable scar, this approach results in significantly more complications. Therefore, the risks and benefits must be weighed and discussed with the caregivers in deciding the surgical approach in patients with IHPS. However, due to a poor methodological quality of nine out of fifteen studies, further studies need to be conducted for an optimal comparison between the two groups.
PURPOSE: To obtain the subject new monoclonal antibody reactive with oncopterin, non-reactive with biopterin and 1,3-diaminopropane and useful e.g. for the immunological determination for the diagnosis of solid cancer such as hepatic cancer, prostatic cancer and bladder cancer. CONSTITUTION: This new oncopterin monoclonal antibody is reactive with oncopterin expressed by the formula and non-reactive with biopterin and 1,3- diaminopropane. It can be used e.g. for the determination of oncopterin in a short determination time per one specimen without necessitating the pretreatment of the specimen and useful e.g. for the diagnosis of cancer, especially solid cancer such as hepatic cancer, prostatic cancer and bladder cancer. The monoclonal antibody can be produced by bonding oncopterin to bovine serum albumin(BSA) using an aqueous solution of glutaraldehyde, immunizing a mouse with the product, collecting spleen cell after the final immunization, fusing the cell with mouse myeloma cell to form a hybridoma, screening the hybridoma to select an antibody-producing strain, cloning the strain and culturing the cloned product.
PURPOSE:To rapidly decide an optimum medical treatment or an emergency measure by fixing a film in which owner's medical information is contracted and recorded with positive to a mounting sheet in which a type of a card and owner's full name are visibly described. CONSTITUTION:A medical card 10 is formed of a rectangular mounting sheet 12, a rectangular film 14 disposed on the sheet 12, and a transparent synthetic resin thin sheet 16 integrally covering the sheet 12 and the film 14 in a sandwich state. The sheet 12 has a rectangular cutout 18. The film 14 is disposed in the cutout 18. The cover 16 is operated as means for fixing the film 14 to the sheet 12. Characters 20 and a mark 22 for specifying a type of the card 10, a card owner's full name 24, a distinction 25 of sex, an identification symbol 28, a forming date 30 are visibly recorded together with the other necessary characters 30, 32 on a surface of the sheet 12 by printing, etc. A medical organization, etc., reads the information recorded on the card 10, and rapidly conducts a patient with optimum medical treatment.
The present invention relates to a medicine for treating poliosis, which belongs to an oral Chinese medicinal preparation. The medicine is characterized in that the dose for one day is prepared from the following Chinese medicinal raw materials: 12g of black sesame, 8g of fleeceflower root, 8g of walnut kernel, 7g of cochinchnese asparagus root, 7g of prepared rhizome of rehmannia, 10g of eclipta herba, 10g of tangshen, 10g of milkvetch root and 8g of incised notopterygium rhizome or root. The medicine has the efficiency of nourishing the liver and kidney, nourishing qi and blood, soothing channels, promoting blood circulation, dispelling wind, arresting itch, preventing alopecia and generating hair. The medicine has the advantages of no side effect, convenient administration and fast effect. The root of hoary hair turns black in one month, and poliosis can be healed in two to five treatment courses; the medicine has obvious therapeutic effects. The tracking data of 200 patients in clinic shows that the cure rate of the medicine is 95%; the medicine is suitable for various kinds of poliosis.
FIELD: medicine. ^ SUBSTANCE: group of inventions concerns ophthalmology and can be used for depression of level of serumal amyloid A protein (SAA) in tissues with glaucomatous changes, for diagnostics of glaucoma and determination of agents, potentially applicable for glaucoma treatment. The ways of SAA levels decrease provide contacting of glaucomatous tissues with agents which interact with a gene modulating SAA expression or inhibit interaction of the SAA protein with its receptor. Methods of diagnostics include obtaining of a biological material from the patient, analysis of the material and conclusion about glaucoma presence at detection of high level of bioactivity, mutation of genes or products of SAA genes. The method of determination agents, potentially applicable for glaucoma treatment includes modes of formation of the reactionary admixture containing cells, including the recombinant SAA protein or expression vectors, and an investigated bond; a stage of definition of effect of a signal transmission in the presence of a tested bond and conclusion formation about possibility of use of an agent for glaucoma treatment if there are changes of a signal transmission in the presence of a tested bond. ^ EFFECT: increase of efficiency of diagnostics and glaucoma treatment. ^ 13 cl, 5 dwg, 1 tbl, 5 ex