anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Behavioural Therapy (CBT) with Motivational Interviewing (MI) techniques. It comprises six individual sessions delivered via real-time video (Zoom) on mobile or computer platforms. Sessions last approximately 45 to 60 minutes each.
A substrate has or is provided on a surface with a first porosity. A  dispersion with low-viscosity liquid is applied to the surface in order to form a ceramic layer with a second porosity having preferably larger and/or more pores than in the first porosity. The liquid has the ability to be sucked by capillary force into the first pore formation and, in a first stage, to retain on the surface material and/or liquid particles which do not penetrate into this first pore formation, and which contribute to the continued construction of the layer. In a second stage, the substrate is subjected to sintering in which the particles finally forming the layer are held together with intermediate spaces which consist of or are included in the second porosity, the spaces being formed either by the fact that material and liquid particles separate from the particles finally forming the layer are driven off during the sintering and/or by the fact that the particles forming the layer are chosen with a particle size which means that the last-mentioned particles are held together after the sintering despite the intermediate spaces. The invention also relates to an arrangement. By means of the invention, a dental product can be provided with excellent porosity which is advantageous in connection with dental installations.
In sleep-related dissociative disorders, phenomena of the psychiatrically defined dissociative disorders emerge during the sleep period. They occur during sustained wakefulness, either in the transition to sleep or following an awakening from sleep. Behaviors during episodes vary widely, and can result in injury to self or others. Daytime dissociative episodes and a background of trauma are almost always present; there is typically major co-existing psychopathology. Diagnosis is based on both clinical history and polysomnography; differential diagnosis primarily involves other parasomnias and nocturnal seizures. Information available about treatment is limited; in a few reported cases, psychological interventions have proven effective.
This phase 2 study assessed the anti-neovascularization activity of intravitreal bevacizumab, as determined by regression of neovascular vessels of retinopathy of prematurity (ROP), in neonates with acute stage 3 ROP in zone I or posterior zone II with plus disease. This study enrolled 150 confirmed cases of vision threatening ROP which have definite plus disease \[ranging from Early Treatment for Retinopathy of Prematurity, to Cryotherapy for Retinopathy of Prematurity . This was done because of the controversy regarding determining plus disease and the increasing concern that many infants are being treated whose ROP would spontaneously regress. Bevacizumab will be administered intravitreally using 0.625 mg (0.025 ml) injections into each eye. There was no intent to give additional doses unless there was a recurrence of vision threatening stage 3 ROP with plus disease since the disease is self limited by completion of vascularization. Clinical response and any evidence of ocular toxicities were documented by retinal imaging system (manufactured by Clarity Medical Systems, Inc.) taken pre-injection, one week and one month post injection, and at 6 months of age (54 weeks postmenstrual age)(window of 50 to 70 weeks PMA)(primary outcome) and at 12 months of age (80 weeks postmenstrual age)(window of 75 to 100 weeks PMA)(structural documentation). Using the same retinal imaging system, fluorescein angiograms have been taken when possible to document structural outcomes in greater detail. No evidence of systemic toxicities were documented by appropriate clinical and laboratory tests.
Patients submitted to general anesthesia and abdominal laparoscopic surgery (number=10) or open surgery (number=10) will be submitted to a recruitment maneuver followed by a PEEP titration procedure EIT. In this arm, the ventilator will be set with a PEEP=4 cmH2O ("Low PEEP") and FIO2 of 0.5 during intraoperative period.
Induction of anesthesia: Chloralhydrat intraperitoneal 300 mg/kg. This provides complete suppression of animal responses to pain, fixation, tracheal intubation. After fixation of the animal in the supine position trachea is intubated and mechanic ventlation with air using an animal respirator is performed.
An isolated and purified nucleic acid comprising a nucleotide sequence which consists of GAT CCA CTG TGC GAC AGC TCG GRG ATC (Seq. Id. No. 1) included in the proto-oncogene RET, which sequence in normal cells has the following sequence in the region defined by position 1810 and adjacent nucleotides including position 1845 and adjacent nucleotides: GAT CCA CTG TGC GAC GAG CTG TGC CGC ACG GTG ATC. Information derived from the altered nucleotide sequence found in a tissue or fluid sample, taken from a patient, can be used for determining the type and character of the rumor. The nucleotide sequence or information derived therefrom is used for the manufacture of reagents for the diagnosing of cancer and for the manufacture of pharmaceutical compositions for prevention and/or treatment of cancer.
Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and the programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) pathway might induce inflammatory potentially serious and even lethal immune related Adverse Events (irAEs). Diarrhea and/or colitis are ones of the most frequently reported irAEs in patients taking ICI, occurring after an average of three infusions. The incidence is higher among patients taking combination anti-CTLA-4/ anti-PD-1 therapy (44%) than those receiving anti-CTLA-4 (23-33%) or anti-PD-1 (≤19%) monotherapy. The most common autoimmune and musculoskeletal irAEs reported in clinical trials are represented by arthralgia and arthritis. The incidence of arthralgia and/or inflammatory arthritis secondary to nivolumab therapy ranges from 5% to 16% and 5%, respectively. Although the immune mechanisms underlying irAEs have not been fully elucidated, studies suggest that Th17 and Tregs cells, increases in expression of immunologically-related genes, eosinophilia, microbiome among others and cytokines may be involved in the pathophysiology of immune-related complications in some diseases that resemble irAEs, such as colitis and rheumatic manifestations. Previous studies report Th-17, that drives interleukin-17 (IL-17) production, as a key mediator of many immune diseases, including inflammatory bowel disease and ICI-induced colitis, and IL-17 elevations have been observed in experimental colitis. Importantly, interleukin-6 (IL-6) promotes the differentiation of naïve CD4+ T cells into Th17 cells (17), and IL-6 inhibition may rebalance the altered Th17-Treg axis without inhibiting the Th1-CD8+ T-cell subsets that govern antitumor immunity. An imbalance of Th17/Treg may cause the onset and progression of immune-mediated side effects. Thus, a 3-fold increase of IL-17 and IL-6 by week 12, concomitant with the development of fulminant colitis has been reported in a patient who developed presumed ipilimumab-induced colitis. These findings raise the possibility of using IL-6 blockade as a strategy for treating colitis and arthritis induced by immune checkpoint blockade.
The invention discloses a kind of methods of the integrated extraction of multiple biological activities ingredient in turmeric, including：S1. curcuma powder homogenization obtains the first homogeneous solid and the first homogeneous liquid；S2. homogenization obtains homogeneous solid and the second homogeneous liquid to the first homogeneous solid again, and the first and second homogeneous liquids of mixing obtain homogeneous liquid；S3. homogeneous solid adds ethyl alcohol extracting and developing to obtain the first solid product and the first product liquid；S4. the first solid product handles to obtain turmeric polysaccharide, and the first product liquid handles to obtain turmeric flavones；S5. isolated second solid product of homogeneous liquid and second liquid product, the isolated third solid product of the second solid product and third product liquid, third solid product it is dry turmeric starch；S6. mixing second and third product liquid post-process to obtain curcumin.Method for integrated extraction provided by the invention improves the utilization rate of turmeric material, improves the recovery rate of multiple biological activities ingredient, economic and environment-friendly.
The invention discloses sesterterpine compounds, and a preparation method and an application thereof. The sesterterpine compounds are compound 1, compound 2, and compound 3. The structural formula is represented as the formula (I). The sesterterpine compounds provided by the invention can be used for preparing acetylcholinesterase inhibitor medicines, wherein the medicines can be used for treating senile dementia. The compound 1 is represented as the following. In the compound 2, R1=H, and R2=OH. In the compound 2, R1=H, and R2=OAc (I).
BACKGROUND: Changed body composition with increased fat content and decreased muscle mass is seen in renal transplantation recipients (RTRs). Increased fat mass might mask underlying muscle mass loss; measuring low body mass index and weight reduction alone may not be sensitive enough to diagnose malnutrition in RTRs. We aimed to determine the prevalence of malnutrition in stable RTRs using the Global Leadership Initiative on Malnutrition (GLIM) criteria and to assess the use of muscle ultrasonography (US) to compare the performance of various muscle US measurements in the diagnosis of reduced muscle mass.
METHODS: Ninety-one patients who had renal transplantation >6 months ago were enrolled in the study. GLIM criteria were performed for all patients, but not those at risk of malnutrition. Bioelectrical impedance analysis and muscle US were performed to identify reduced muscle mass.
RESULTS: The prevalence of malnutrition according to GLIM criteria was 25.3% (n = 23). All muscle US measurements were lower in the malnourished group than the well-nourished group; however, the malnourished group had substantially lower muscle thicknesses in abdominal muscles, specifically the external oblique (EO) and internal oblique (IO) muscles, than the well-nourished group (P = 0.001 and P = 0.007, respectively). There was a significant association between malnutrition and EO (odds ratio [OR] = 0.338, 95% CI = 0.163-0.699; P = 0.003) and IO (OR = 0.620, 95% CI = 0.427-0.900; P = 0.012) regardless of age and sex.
CONCLUSION: One in four RTRs experience malnutrition. Muscle US could be used effectively for the diagnosis of reduced muscle mass and malnutrition in RTRs according to GLIM criteria.
Patients should be counseled that antibacterial drugs including clarithromycin should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When clarithromycin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by clarithromycin or other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

Clarithromycin tablets may interact with some drugs; therefore patients should be advised to report to their doctor the use of any other medications.

Clarithromycin tablets can be taken with or without food and can be taken with milk.
This is a prospective, randomised pilot study comparing the health economic outcomes between TKA using standard instrumentation and TKA using a patient-matched cutting guide. The primary indication for this study is degenerative arthritis of the knee requiring unilateral primary total knee arthroplasty. Patients requiring TKA who are eligible and have consented to participate will be randomised to TKA with The Genesis II™ Total Knee Implant System or the Legion™ Primary Total Knee System using either Visionaire™ patient-matched cutting guides or standard instrumentation. The study will recruit for 1 year and patients will have a final follow up at the six week post-operative assessment.

The primary objective of this study will evaluate the cost of the episode of care from hospital admission to discharge. This will include pre-operative costs, anesthetic costs, operative and theatre costs, costs of instruments and resources. The study will also measure length of stay as well as blood transfusion requirements. The secondary objectives of this study are to compare the safety and early readmission rates between the two techniques, by measuring the complication rates intra-operatively and post-operatively as well as the number of patients readmitted to hospital prior to the six week post-operative assessment.
MACS patients with AVS-confirmed lateralisation the left adrenal gland and CT showing left-sided tumour will be included in this study group after signed consent. EUS will be performed, and a EUS-guided fine needle tissue sampling of the adenoma will be performed, before a subsequent EUS-RFA treatment procedure. Follow-up after 2 weeks, 3 months and 12 months for evaluation of clinical and biochemical outcome, and procedural complications.
PROBLEM TO BE SOLVED: To obtain a compsn. for the preparation of a chitosan soln. which enables a chitosan soln. to be prepd. in a job site when required in a necessary amt. in a simple and quick manner and causes no change in quality by oxidation by mixing a fine powder of chitosan having a specified particle size with a fine powder of an org. acid having a specified particle size. SOLUTION: A fine powder of chitosan having a size exceeding 60 mesh and a fine powder of an org. acid, pref. vitamin C (ascorbic acid), having a size exceeding 60 mesh are mixed together pref. in a wt. ratio of chitosan to the org. acid of 1:(0.8 to 3.0). That is, addition of water to the compsn. just before use enables a chitosan soln. to be prepd. in a short time. For both chitosan and org. acid, the particle size is pref. small because the solubility increases with decreasing the particle size so far as the particle size exceeds 60 mesh. The org. acid is not limited to ascorbic acid so far as it can be brought to a fine powder, and other org. acids usable herein include acetic acid, malic acid, citric acid, citric anhydride, and tartaric acid.  The chitosan soln. is useful for application on a leaf surface, soil irrigation, seed overhead flooding and the like in the production of crops.
Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5'untranslated region (5'UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans, can bind to the cellular proteins and antagonize their binding to the viral IRES, thereby inhibiting HCV IRES-mediated translation. We have found that an RNA molecule corresponding to SL III of the HCV IRES could efficiently inhibit HCV IRES-mediated translation in a dose-dependent manner without affecting cap-dependent translation. The SL III RNA was also found to bind efficiently to most of the cellular proteins which interacted with the HCV 5'UTR. A smaller RNA corresponding to SL e+f of domain III also strongly and selectively inhibited HCV IRES-mediated translation. This RNA molecule showed strong interaction with the ribosomal S5 protein and prevented the recruitment of the 40S ribosomal subunit by the HCV IRES. In conclusion our results demonstrate a novel approach to selectively block HCV RNA translation using a small RNA molecules mimicking the structure of the stem-loop IIIe+f subdomain of the HCV-IRES. The discovery provides a basis for developing a potent antiviral therapy targeting the interaction between the ribosome and the HCV-IRES RNA.
Automated workflow by software executing on at least one processor includes receiving a plurality of echocardiographic images taken by an ultrasound device. A first filter separates the plurality of echocardiographic images from the 2D image and the doppler modality image based on analyzing the image metadata. The first neural network classifies the 2D image by view type, and the second neural network classifies the doppler modality image by view type. The third neural network segments a heart chamber in the 2D image, and the fourth neural network segments the doppler mode image to generate a waveform trajectory, producing a segmented 2D image and a segmented doppler mode image. Using these two sets of images, measurements of cardiac features are calculated for both the left and right sides of the heart. The calculated measurements are compared to an international cardiac guideline to generate a conclusion, and a report highlighting measurements beyond the guideline is output.
SCOPE: Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non-alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF-β is a multifunctional polypeptide molecule that acts as a pro-fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro-carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF-β can induce epithelial-to-mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF-β pathway can be a promising therapeutic option against HCC.
METHODS AND RESULTS: We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF-β pathway against liver cancer.
CONCLUSION: Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation-induced HCC and they also have the maximum number of ongoing in-vivo and in-vitro studies.
An ECG-synchronized, contrast-medium enhanced CT study of the heart for the evaluation of the aortic root complex and general cardiac morphology will be obtained. This is immediately followed by a CT angiographic study of the chest, abdomen, and pelvis (beyond the femoral heads), which utilizes the same contrast bolus that is injected for evaluating the heart. This latter vascular study serves to evaluate the TAVR deployment catheter access route through the femoral, iliac, and aortic vascular stations. In clinical routine, we have been performing this type of study with total contrast media volumes ranging from 40-120 mL of iodinated contrast material.
This is the treatment B by continuous subcutaneous hydrocortisone infusion. Solu-cortef infusion will be given as Solu-Cortef Act-o-Vial 50mg/ml, , produced by Pfizer. Pump designed for subcutaneous insulin infusion can be used for subcutaneous administration.
Standard prophylaxis dose anticoagulation will be the anticoagulation of choice in the control arm. Enoxaparin will be the primary agent for anticoagulation, with unfractionated heparin reserved only for patients with creatinine clearance of ≤15 mL/min according Cockcroft-Gault Formula.
The invention provides a method and a system for reducing noise of a deep learning image special for a patient. Systems and methods for improving image noise reduction using a deep learning network model are disclosed. An exemplary system includes an input data processor for processing a first patient image of a first patient to add first noise to the first patient image to form a noisy image input. An exemplary system includes an image data noise reducer for processing a noisy image input using a first deep learning network to identify first noise. The image data noise reducer is used to train a first deep learning network using noisy image inputs. When the first deep learning network is trained to identify first noise, the image data noise reducer is to deploy the first deep learning network as a second deep learning network model to apply to a second patient image of the first patient to identify second noise in the second patient image.
PURPOSE: A process for preparing a medical composition for the prevention and treatment of allergy by mixing a suitable amount of specified herb medicines is provided. Whereby, the composition can inhibit allergy and reduce catching a cold as well as treating rhinitis by stimulating immunity of an infant. CONSTITUTION: The titled composition contains a Chinese bellflower, Scutellaria baicalensis George, Trifoliate orange, Schizonepeta tenuifolia Briq., Bupleurum falcatum L., Angelica dahurica (Fisch.) Benth. et Hooker f., Paeonia lactiflora Pall. var. trichocarpa Bunge, Cnidium officinale Makino, Angelicae Gigantis Radix, Ledebouriella seseloides (Hoffm.) Wolff, Forsythia koreana Nakai, Glycyrrhizae radix, Taraxacum mongolium Hand.-Mazz, Trichosanthes kirilowii Max., Ulmus parvifolia Jacq., Astragalus membranaceus Bunge, Atractylodes japonica, Rubia akane Nakai, Magnolia kobus DC. Morus alba L., Pinellia ternata (Thunb.) Breitenb, Cimicifuga heracleifolia Kom., Pueraria thunbergiana Benth and Mentha arvensis var. piperascens Malinv.
Homozygous familial hypercholesterolemia (FH) is a serious life-threatening genetic disease. Total plasma cholesterol levels are generally over 500 mg/dl and markedly premature cardiovascular disease is the major consequence. Untreated, most patients develop atherosclerosis before age 20 and generally do not survive past age 30. The primary goal of therapy involves reducing cholesterol (specifically, LDL cholesterol) and preventing coronary artery disease. Unfortunately, patients with homozygous FH are minimally responsive or unresponsive to available drug therapy and thus there are limited treatment options. The current standard of care is LDL apheresis, a physical method of removing the plasma of LDL cholesterol which can transiently reduce cholesterol by more than 50%. However, there is rapid re-accumulation of LDL cholesterol in plasma, and therefore apheresis has to be repeated frequently (every 1-2 weeks) and requires 2 separate sites for IV access. Although anecdotally this procedure may delay the onset of atherosclerosis, it is laborious, expensive, and not readily available. Furthermore, although it is a procedure that is generally well tolerated, the fact that it needs frequent repetition and IV access can be challenging for many of these young patients. Therefore, there is a tremendous unmet medical need for new medical therapies for this orphan disease.

AEGR-733 is a novel oral therapeutic agent for hypercholesterolemia. Its mechanism involves inhibition of microsomal triglyceride transfer protein, resulting in a reduction of LDL cholesterol. Earlier studies in patients with homozygous FH reveal AEGR-733 is highly effective in lowering LDL cholesterol, yet long term safety and efficacy need to be established.