anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Mast cell degranulation inhibitors having a carboxyl group have not been used as medicines for external application, because of their low transdermal permeatibility. If the inhibitors are administered through transdermal application, any adverse side effect on organs in the body which may be produced when administered via an oral route administration could be avoided. Further, some of the mast cell degranulation inhibitors have an extremely poor photostability. This contributes to the difficulty in the development of a medicine for external application comprising the inhibitor. The transdermal permeability and photostability of a mast cell degranulation inhibitor can be improved by using the inhibitor in the form of a salt with an organic amine. Thus, disclosed is a preparation for external application comprising a mast cell degranulation inhibitor. The mast cell degranulation inhibitor and a preparation comprising the mast cell degranulation inhibitor can be improved in photostability.
The invention relates to the technical field of medicines, in particular to an external washing medicine for hemorrhoids and fistula, a preparation method and an application method thereof. The external washing medicine for hemorrhoids and fistula comprises the following components in parts by weight: 40-60 parts of radix sophorae flavescentis, 15-25 parts of golden cypress, 30-50 parts of mirabilite, 10-30 parts of vinegar folium artemisiae argyi, 10-30 parts of lithospermum and 20-40 parts of alum. The medicine can be used for postoperative treatment of anorectal patients, and can effectively promote postoperative recovery of anorectal patients. The preparation method of the external washing medicine for hemorrhoids and fistula comprises the steps of weighing the raw materials according to the parts by weight, decocting the weighed raw materials with water to obtain a medicinal liquid, and bagging the medicinal liquid to obtain the external washing medicine for hemorrhoids and fistula. The preparation method is simple, and effective components in the traditional Chinese medicine can be effectively extracted. The application method of the external washing medicine for hemorrhoids and fistula is that the external washing medicine for hemorrhoids and fistula is adopted to carry out local ultrasonic atomization fumigation and washing treatment on the wound surface after the operation of a patient. The application method is simple, and effective components in the medicine can be effectively excited.
Disclosed is a temporary hair colour composition comprising an encapsulated liquid crystal, and optionally an iridescent component, and a coating composition comprising a thickening agent and a rheology modifier. The rheology modifier preferably comprises a glycol. Preferably, the thickening agent is poly(acrylate) based, a polyquaternium compound, a polyvinyl pyrollidone/vinyl acetate copolymer, or a hydrophobically modified starch. Preferably, the glycol is a polyalkylene glycol or a C2-C4 alkylene glycol, e.g. propylene glycol. Preferably, the liquid crystal comprises a cholesteric and/or a chiral nematic liquid crystal. Preferably, the encapsulated liquid crystal is incorporated into the composition as an aqueous slurry. Preferably, the iridescent component has a particle size of 1-50 micron or 50 to 200 micron. Also claimed is a method of colouring hair comprising adding the hair colour composition to hair. Further claimed is the use of a temporary hair colour composition for cosmetically treating hair.
BACKGROUND Acute exacerbations of COPD (AECOPD) are of major importance since they are associated with adverse effects on morbidity, health status, and costs. Conventional treatment includes the use of antibiotics and oral corticosteroids (OCS). However, OCS is associated with significant side effects. This is of considerable importance since exacerbation occurs on average 2 to 4 times per year in COPD patients. Alternative treatment such as high dose inhaled corticosteroids has also been shown to be effective in the treatment of AECOPD. Recently, studies have clearly demonstrated the effect of combination therapy (SFP) on key inflammatory cells and a marked enhance anti-inflammatory effect when compared to inhaled corticosteroids alone. Inhaled corticosteroids have a high level of topical anti-inflammatory activity and a low level of systemic. Additionally, combination therapy with inhaled corticosteroids and long-acting β2-adrenoceptor agonists (SFP) appears to produce significant anti-inflammatory effects in COPD airways that are not seen when inhaled or oral steroids are used alone. This could offer a potential for an alternative treatment to oral corticosteroids in AECOPD.

RATIONALE None of the inhaled treatments is likely to be adopted and to replace the use of OCS for the treatment of AECOPD unless it is used promptly at the onset of symptom worsening. Early treatment has been shown to have clinical importance in accelerating symptom recovery and reducing hospital admission. Recently, the investigators have demonstrated that the early treatment of AECOPD can be achieved by the implementation of a written action plan as part of a self-management education.

The use of action plans helps COPD patients recognize symptom changes, implement self-care and self-initiate a customized prescription (antibiotics \& oral steroids) in the event of an exacerbation. Self-management education programs with a written action plan that includes standing prescriptions with combination therapy (SFP) in the event of an exacerbation may be promising in reducing the use of prednisone in AECOPD, the conventional treatment.
Maternal exposure to particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) is believed to be a risk factor of developmental origins of health and disease (DOHaD), but its effect on offspring's susceptibility to obesity, a common target disease of DOHaD, remains controversial. To pinpoint the effect of maternal PM2.5 exposure on offspring's energy homeostasis, female C57BL/6J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) for 12 weeks and mated with normal male mice to produce offspring. After parturition, a cross-fostering strategy was exploited to determine whether prenatal and/or postnatal mothering by CAP-exposed dams program offspring's energy homeostasis and susceptibility to obesity. Moreover, oocytes were collected from FA- or CAP-exposed mice and subjected to in vitro fertilization (IVF) to determine whether maternal pre-conceptional exposure to PM2.5 programs energy homeostasis. Results showed that prenatal mothering by CAP-exposed dams increased suckling's milk intake and weight gain, decreased normal diet (ND)-fed offspring's adulthood food intake and body weight, and did not influence offspring's diet-induced obesity (DIO). Postnatal mothering by CAP-exposed dams did not influence suckling's milk intake and weight gain, increased ND-fed offspring's adulthood food intake and body weight and did not influence offspring's DIO. Prenatal plus postnatal mothering by CAP-exposed dams increased suckling's milk intake and weight gain, increased ND-fed offspring's adulthood food intake and body weight, and aggravated offspring's DIO. IVF study revealed that male offspring derived from CAP-exposed mice versus controls had significantly decreased adulthood food intake and body weight. RNA sequencing showed that CAP exposure influenced oocyte estrogen signaling and histone methylation. This study thus clearly reveals that timing determines programming of energy homeostasis by maternal PM2.5 exposure.
This study aimed to develop polysorbate 80-coated chitosan nanoparticles (PS80/CS NPs) as a delivery system for improved brain targeting of α-Melanocyte Stimulating Hormone analog (NDP-MSH). Chitosan nanoparticles loaded with NDP-MSH were surface-modified with polysorbate 80 ([NDP-MSH]-PS80/CS NP), which formed a flattened layer on their surface. Nanoparticle preparation involved ionic gelation, followed by characterization using scanning electron microscopy (SEM) for morphology, dynamic light scattering (DLS) for colloidal properties, and ATR-FTIR spectroscopy for structure. Intraperitoneal injection of FITC-PS80/CS NPs and [NDP-MSH]-PS80/CS NP in rats demonstrated their ability to cross the blood-brain barrier, reach the brain, and accumulate in CA1 neurons of the dorsal hippocampus within 2 h. Two experimental models of neuroinflammation were employed with Male Wistar rats: a short-term model involving high-fat diet (HFD) consumption for 5 days followed by an immune stimulus with LPS, and a long-term model involving HFD consumption for 8 weeks. In both models, [NDP-MSH]-PS80/CS NPs could reverse the decreased expression of contextual fear memory induced by the diets. These findings suggest that [NDP-MSH]-PS80/CS NPs offer a promising strategy to overcome the limitations of NDP-MSH regarding pharmacokinetics and enzymatic stability. By facilitating NDP-MSH delivery to the hippocampus, these nanoparticles can potentially mitigate the cognitive impairments associated with HFD consumption and neuroinflammation.
A method using a specially configured computer display support structure reduces occurrences of medical errors by facilitating real-time, synchronous review of medical data by rounding professionals during patient rounds. The support structure includes an upright column assembly that has a column assembly base and six sides. Mounting brackets fixed to non-contiguous sides of the column assembly receive back plates of a system device mounting assembly, each of which includes a pivot arm that receives a system device arm. The system device arm is pivotable at opposing ends and terminates in a coupling member at its distal end. The coupling member is connected to a video display that has an angularly positionable display screen. In some embodiments, a keyboard tray, on which a keyboard and computer mouse rest, is connected to the coupling member.
FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of aminothiazole of the formula (I)   and their pharmaceutically acceptable salts wherein R 1  and R 2  mean independently each of other hydrogen, fluorine atom or lower alkyl; R 3  means heteroaryl taken among oxazolyl that is substituted with one or some substituents taken among a lower alkyl, halogen atom, carbamoyl, alkyloxycarbonyl, alkyl- carbonyloxy or benzoxazole; R 4  means hydrogen atom, CO-alkyl that can be optionally substituted with halogen atom, alkoxy, hydroxy, alkyl- oxycarbonyl, alkylcarbonyloxy, amino, carbamoyl; CO-cycloalkyl; CO-aryl wherein aryl represents phenyl that can be optionally substituted with halogen atom, lower alkyl, alkoxy, amino, cyano or naphthyl group and so on; or COO-alkyl; COO-cycloalkyl; COO-phenyl; COO-alkyl- phenyl; SO 2 -alkyl; SO 2 -phenyl; C(NCN)NH-phenyl wherein phenyl can be optionally substituted with halogen atom; R 5  means hydrogen atom; m means a whole number from 0 to 2; n = 0. Invention relates also to a pharmaceutical composition eliciting as an inhibitor of protein kinase that comprises compound of the formula (I) and a pharmaceutically acceptable carrier and to a pharmaceutical composition eliciting effect of protein kinase inhibitor containing compound of the formula (I), a pharmaceutically acceptable carrier and an anticancer agent. Invention relates also to method for inhibition of activity of cyclin-dependent kinases involving administration of effective dose of compound of the formula (I) in mammal needing in such treatment. Invention provides preparing novel derivatives of isothiazole carboxylic acid. EFFECT: valuable medicinal properties of compounds. 26 cl, 2 tbl, 639 ex
Although oxycodone may cross-react with some drug urine tests, no available studies were found which determined the duration of detectability of oxycodone in urine drug screens. However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure.

Urine testing for opiates may be performed to determine illicit drug use and for medical reasons such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug rehabilitation efforts. The preliminary identification of opiates in urine involves the use of an immunoassay screening and thin-layer chromatography (TLC). Gas chromatography/mass spectrometry (GC/MS) may be utilized as a third-stage identification step in the medical investigational sequence for opiate testing after immunoassay and TLC. The identities of 6-keto opiates (e.g., oxycodone) can further be differentiated by the analysis of their methoximetrimethylsilyl (MO-TMS) derivative.
Standard support for 12 months (HAS 2010, EULAR 2016) 3 fibromyactiv workshops per week during the first 6 months, or 72 sessions. Each workshop lasts 2 hours of physical activity.
Chronic pain presents significant personal, psychological, and socioeconomic hurdles, impacting over 30% of adults worldwide and substantially contributing to disability. Unfortunately, current pharmacotherapy often proves inadequate, leaving fewer than 70% of patients with relief. This shortfall has sparked a drive to seek alternative treatments offering superior safety and efficacy profiles. Cannabinoid-based pharmaceuticals, notably cannabidiol (CBD), hold promise in pain management, driven by their natural origins, versatility, and reduced risk of addiction. As we navigate the opioid crisis, ongoing research plunges into CBD's therapeutic potential, buoyed by animal studies revealing its pain-relieving prowess through various system tweaks. However, the efficacy of cannabis in chronic pain management remains a contentious and stigmatized issue. The International Association for the Study of Pain (IASP) presently refrains from endorsing cannabinoid use for pain relief. Nevertheless, evidence indicates their potential in alleviating cancer-related, neuropathic, arthritis, and musculoskeletal pain, necessitating further investigation. Crucially, our comprehension of CBD's role in pain management is a journey still unfolding, with animal studies illustrating its analgesic effects through interactions with the endocannabinoid, inflammatory, and nociceptive systems. As the plot thickens, it's clear: the saga of chronic pain and CBD's potential offers a compelling narrative ripe for further exploration and understanding.
This study proposes to provide the reference range of cortisol results when the ACTH stimulation test is done under stressful conditions. This important information is currently not available in the literature. To achieve this, we will perform the ACTH stimulation test in a cohort of patients who are booked for elective surgery. By choosing elective surgery patients, we afford ourselves the opportunity of performing the test once before surgery. The test is then repeated within 12 hours of surgery. The first test will be done on an out-patient basis under usual conditions (minimal stress) while the second will be done under intense physical stress. The 2 sets of results will be compared and the effect of stress on test results will be determined. For the sake of uniformity, we have chosen patients who are booked to undergo repair of an abdominal aortic aneurysm (AAA) as our study cohort.

The ACTH stimulation is an important test that suffers from limitations resulting from lack of clear guidelines for the interpretation of results done under stressful conditions. This study will thus improve the usefulness of an important tool in the evaluation of the hypothalamic-pituitary-adrenal axis in stressed patients.
The invention relates to a production technology of purslane polysaccharide. The production technology comprises the following steps that: impurities in purslane are removed; purslane is washed, cut into segments, and dried; processed purslane is immersed in water for 30 minutes, and is extracted 3 times through microwave auxiliary extraction; in a vacuum heating condition, pressure reduction concentration is carried out on the purslane extract, such that a condensed purslane extract is obtained; a small amount of ethanol is added to the condensed purslane extract, and the mixture is stirred and well-mixed; the mixture is then stood for 24 hours, and a precipitate is obtained; the precipitate is diluted with a proper amount of water; chloroform and n-butanol are added to the diluted precipitate, and the mixture is mixed and oscillated for 30 minutes. Obtained protein-removed crude purslane polysaccharide is diluted with a small amount of water, and the diluted crude purslane polysaccharide is eluted in macroporous adsorption resin; active carbon is added to a polyamide eluate for adsorbing, and active carbon is removed; hydrogen peroxide is added to the obtained material, the mixture is well-mixed, decolored, and heated; residual hydrogen peroxide is then removed; the obtained material is vacuum-dried, such that purslane polysaccharide with a relatively high purity is obtained. The produced purslane polysaccharide has functions of immunity improving, tumor resisting, oxidation resisting, and aging resisting. The purslane polysaccharide has a hypoglycemic effect, and can be used for changing diabetes symptoms. Purslane polysaccharide has a good anti-tumor function, and can be applied in the development of anti-tumor medicines.
SAPB single injection (placebo). 30ml of SodiumChloride 0.9 is injected above m. serratus anterior after thoracoscopic lung surgery. Infection is done under ultrasound guidance.
Short gestational intervals are known to be directly associated with adverse pregnancy outcomes, such as gestational diabetes, maternal obesity, anemia, maternal mortality, severe maternal morbidity, preterm delivery, low birth weight, and infant mortality. The most important step in establishing optimum pregnancy intervals can be achieved by meeting the contraceptive needs of postpartum women. Motivational interviewing incorporates components of contraception counseling best practices, such as building trust, optimizing the decision-making process, improving self-efficacy, and protecting the autonomy of the individual, which allows it to be actively used in the counseling process. Therefore, this study aimed to investigate the effects of transtheoretical model-based motivational interviewing on postpartum contraception. In this study, the intervention group will receive two motivational counseling sessions in the antenatal period and one motivational interviewing session in the postnatal period in addition to routine care, while the control group will receive only routine care. The data will be coded as A and B in SPSS (Statistical Package for the Social Sciences) and analyzed by an independent statistical expert.
OBJECTIVES: Low back pain (LBP) among caregivers in Japanese nursing homes has long been considered an occupational health issue. This study aimed to verify the reliability and validity of our developed Japanese version of the Movement and Assistance for Hospitalized Patients (J-MAPO) index, a risk assessment tool for LBP, in nursing homes.
METHODS: Two inspectors assessed 15 nursing homes using J-MAPO, and deduced 3 LBP risk levels as follows: low, moderate, and high risk. Caregivers in nursing homes responded to a self-administered questionnaire on LBP over the past 12 months. Data from 296 caregivers with no missing data were used. We further used logistic regression models to analyze the association between LBP as a dependent variable, and J-MAPO risk level as an independent variable. We used Cohen kappa coefficient to assess interrater reliability to further assess the agreement between the 2 inspectors.
RESULTS: The multivariate logistic regression analysis showed that the adjusted odds ratio and 95% CIs for LBP increased progressively with J-MAPO risk level (Low-risk: 1.00; Moderate-risk: 1.70 [0.74-3.91]; High-risk: 2.67 [1.28-5.56]). Furthermore, the J-MAPO risk levels assessed by the 2 inspectors were in perfect agreement (κ = 1) observed for interrater reliability using Cohen kappa coefficient.
CONCLUSIONS: There was high interrater reliability, and J-MAPO risk levels were associated with LBP. Therefore, our results suggest that the J-MAPO is a useful risk assessment tool for LBP in Japanese nursing homes.
Patients receive tamoxifen citrate PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients with disease progression and bone metastases may cross over to Arm I and receive z-endoxifen hydrochloride starting no later than 28 days after documentation of disease progression.
Risk Summary   
There is no information regarding the presence of bexagliflozin in human milk, the effects on the breastfed infant or the effects on milk production. Bexagliflozin is excreted in the milk of lactating rats (see Data) . When a drug is present in animal milk, it is likely that the drug will be present in human milk. Since human kidney maturation occurs in utero and during the first 2 years of life when lactational exposure may occur, there may be risk to the developing human kidney. Because of the potential for serious adverse reactions in a breastfed infant, including the potential for bexagliflozin to affect postnatal renal development, advise patients that use of bexagliflozin tablets is not recommended while breastfeeding. 

Data   
Bexagliflozin was present in rat milk at a milk:plasma ratio of approximately 2. The concentration of bexagliflozin in animal milk does not necessarily predict the concentration of bexagliflozin in human milk. 

Juvenile rats directly exposed to bexagliflozin showed a risk to the developing kidney (renal pelvic and tubular dilatation) during the period of renal development in rats corresponding to the late second and third trimester of human renal development.
Sepsis is recognized as a major contributor to the global disease burden, but there is a lack of specific and effective therapeutic agents. Utilizing Mendelian randomization (MR) methods alongside evidence of causal genetics presents a chance to discover novel targets for therapeutic intervention. MR approach was employed to investigate potential drug targets for sepsis. Pooled statistics from IEU-B-4980 comprising 11,643 cases and 474,841 controls were initially utilized, and the findings were subsequently replicated in the IEU-B-69 (10,154 cases and 454,764 controls). Causal associations were then validated through colocalization. Furthermore, a range of sensitivity analyses, including MR-Egger intercept tests and Cochran's Q tests, were conducted to evaluate the outcomes of the MR analyses. Three drug targets (PSMA4, IFNAR2, and LY9) exhibited noteworthy MR outcomes in two separate datasets. Notably, PSMA4 demonstrated not only an elevated susceptibility to sepsis (OR 1.32, 95% CI 1.20-1.45, p = 1.66E-08) but also exhibited a robust colocalization with sepsis (PPH4 = 0.74). According to the present MR analysis, PSMA4 emerges as a highly encouraging pharmaceutical target for addressing sepsis. Suppression of PSMA4 could potentially decrease the likelihood of sepsis.
Vitamin D sufficient patients receive no intervention. Vitamin D insufficient patients receive cholecalciferol PO once weekly for 12 weeks and then once monthly for a total of 36 months.