anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To purify economically the titled substance useful as an effect enhancer, e.g. urokinase pharmaceutical, by removing proteins, e.g. plasmin, from blood plasma and urine, and subjecting the resultant material to the steps through affinity chromatography, ion exchange and adsorption chromatography. CONSTITUTION:For example, blood plasma is passed through lysinesepharose gel, and plasmin, plasminogen, etc. are removed therefrom. The resultant liquid after passing through the gel is then subjected to affinity chromatography, and the adsorbed proteins are then eluted with a buffer solution and then dialyzed. The eluate after the dialysis is then subjected to ion exchange chromatography and gel filtration to purify stably urokinase converted protease in high purity and yield. The resultant purified protease can be supplied as an effect enhancer, e.g. urokinase pharmaceutical, tissue plasminogen activator pharmaceutical, etc. The method is useful for purifying a high polymer urokinase of high quality obtained by removing the titled substance utilizing the above-mentioned method.
The STIMUL Group participants in the Adaptive Physical Activity Focus (APA) program receive access to an online digital Platform, as well as a starter kit consisting of a connected pedometer measuring several physical activity indicators including the number of steps, number of so-called active minutes, sleep time, and distance travelled; a tape measure and a starter guide. They then conduct a remote assessment and motivational interview by videoconference or telephone, followed by 15-20 minute support interviews (month 1, month 3, month 6). Between these interviews, during months 1, 2, and 3, participants exchange weekly written messages with an educator on their platform. A planner of their physical activity objectives is provided.
PURPOSE: Several descriptions of the anatomy of the pectoralis major (PM) have been published. However, the precise description of its distal humeral insertion, which is involved in traumatic tears, remains controversial. The distal tendon is classically described as being made of two layers, one anterior (ALPM) and one posterior (PLPM), which regroup at their distal edge. The clavicular head (CH) participates in the ALPM according to most authors. However, others describe a more superficial termination in a close relationship with the deltoid humeral insertion. The objective of this anatomical work is to precisely describe the anatomy of the CH and its relationship with the rest of the distal PM tendon and the distal deltoid tendon.
MATERIALS: Twenty-three fresh cadaveric specimens were dissected (41 shoulders). The entire PM as well as the deltoid were exposed. Several measurements were collected to establish the relationships between the distal tendon of the CH and the PM, the deltoid and the bony landmarks.
RESULTS: In all cases, the CH muscular portion sits on the ALPM but does not participate in the connective structure of the PM distal tendon. The inferolateral part of its distal end gives a thin tendinous portion that inserts lower on the humerus in conjunction with the distal tendon of the deltoid. In 24.4%, this tendon was more difficult to isolate but was always observed.
CONCLUSIONS: The distal tendon of the PM only comes from the muscle fibres of its sternal head. The CH fibres do not contribute to this tendon but appear to terminate in a separate tendon fusing with the humeral insertion of the deltoid: the deltopectoral tendon. This could explain the different patterns of tears observed in clinical practice.
Epilepsy, a neurological disorder affecting over 50 million individuals globally, is characterized by an enduring predisposition and diverse consequences, both neurobiological and social. Acquired epilepsy, constituting 30% of cases, often results from brain-damaging injuries like ischemic stroke. With one third of epilepsy cases being resistant to existing drugs and without any preventive therapeutics for epileptogenesis, identifying anti-epileptogenic targets is crucial. Stroke being a leading cause of acquired epilepsy, particularly in the elderly, prompts the need for understanding post-stroke epileptogenesis. Despite the challenges in studying stroke-evoked epilepsy in rodents due to poor long-term survival rates, in this presented study the use of an animal care protocol allowed for comprehensive investigation. We highlight the role of matrix metalloproteinase-9 (MMP-9) in post-stroke epileptogenesis, emphasizing MMP-9 involvement in mouse models and its potential as a therapeutic target. Using a focal Middle Cerebral Artery occlusion model, this study demonstrates MMP-9 activation following ischemia, influencing susceptibility to seizures. MMP-9 knockout reduces epileptic features, while overexpression exacerbates them. The findings show that MMP-9 is a key player in post-stroke epileptogenesis, presenting opportunities for future therapies and expanding our understanding of acquired epilepsy.
The etiology of bronchiectasis, known as permanent, abnormal, and localized development of bronchi, varies. However, most of them are responsible for infections during childhood. The prevalence of bronchiectasis is particularly high in advanced COPD patients. This phenomenon, called COPD-bronchiectasis overlap syndrome, affects the clinic of COPD patients negatively. In this study; bronchiectasis in respiratory function, exercise capacity, dyspnoea and quality of life in COPD patients.

Torax CTs of patients with COPD who are admitted to the outpatient clinic will be examined. There will be two groups, group 1 in patients with COPD accompanied by bronchiectasis and group 2 in COPD patients without bronchiectasis. In both groups, respiratory function tests, exercise capacities, dyspnea perceptions and quality of life will be evaluated. The data will be compared between the two groups.
OBJECTIVE: Owing to the ageing population the implantation rate of total knee arthroplasty (TKA) continues to rise. Aseptic revisions in primary TKA are one of the main causes of revision. The aim of the following study was to determine the incidence of and reasons for aseptic revision in constrained and unconstrained TKA and in unicondylar knee arthroplasty (UKA).
METHODS: The data collection was carried out with the help of the German Arthroplasty Register (EPRD). The reasons for aseptic revision surgery were worked out using this. The incidence and the comparison of aseptic revisions were analysed with the aid of Kaplan-Meier estimates. A multiple Chi-squared test with the Holm method was used to identify group differences in collateral ligament deficiencies.
RESULTS: In total, 300,998 cases of knee arthroplasties were analysed, of which 254,144 (84.4%) were unconstrained TKA, 9993 (3.3%) were constrained TKA and 36,861 (12.3%) were UKA. The rate of aseptic revisions was significantly increased compared with unconstrained and constrained TKA (p < 0.0001). In constrained TKA, a revision rate of 2.0% for aseptic reasons was reported, whereas in unconstrained TKA 1.1% and in UKA 2.7% revision surgeries were identified. After 7 years the rates of aseptic revisions amounted to 3.3% for constrained TKA, 2.8% for unconstrained TKA and 7.8% for UKA. Ligament instability was the most common cause of aseptic revisions and accounted for 13.7% of unconstrained TKA. In constrained TKA ligament instability led to a revision in 2.8% of cases. In UKA, tibial loosening was identified to be the most common cause of revisions at 14.6%, whereas the progression of osteoarthritis was responsible for 7.9% of revisions. Ligament instability was observed in 14.1% of men compared with 15.9% of women in unconstrained TKA and in UKA in 4.6% of cases for both sexes.
CONCLUSION: In patients with UKA the rates of aseptic revision are significantly higher than in unconstrained and constrained TKA. Ligament instability was the most common cause of aseptic revision in unconstrained TKA. In UKA, tibial loosening was the most common cause of revision surgery, whereas the progression of osteoarthritis was the second most common cause. Comparable levels of ligament instability were observed in both sexes.
LEVEL OF EVIDENCE: III, cohort study.
The current lack of a tool to measure the overall quality of neuraxial pain relief provided in labour analgesia trials has produced studies unable to provide clear direction to clinical care and research. Our previous work explored and described the underlying dimensions and attributes of quality neuraxial analgesia from the perspectives of labouring women as the initial phase of development of an Index to measure this as an outcome in research. We now seek to confirm our findings as well as to generate additional items (descriptors) of quality neuraxial analgesia from the perspectives of parturients and experts (obstetrical anesthesiologists and experienced labour nurses). Once generated, the full list of items will be used to in a subsequent study involving only parturients (Item Reduction phase) to develop a scale permitting global measurement of quality neuraxial labour analgesia. The resulting scale, once validated, will provide researchers with a simple global measure for quality in labour analgesia research. This scale will be used later in our program of research to assist with validation studies of the larger Multi-attribute Health Index we are developing.
In 2016, Hao and Friedman developed a deterministic model of Alzheimer's disease progression using a system of partial differential equations. This model describes the general behavior of the disease, however, it does not incorporate the molecular and cellular stochasticity intrinsic to the underlying disease processes. Here we extend the Hao and Friedman model by modeling each event in disease progression as a stochastic Markov process. This model identifies stochasticity in disease progression, as well as changes to the mean dynamics of key agents. We find that the pace of neuron death increases whereas the production of the two key measures of progression, Tau and Amyloid beta proteins, decelerates when stochasticity is incorporated into the model. These results suggest that the non-constant reactions and time-steps have a significant effect on the overall progression of the disease.
The invention discloses a medicament for treating hyperosteogeny and lumbar intervertebral disc herniation. The medicament can be a separate powder preparation for external application and can also consist of a powder preparation for external application and a water preparation for oral administration. The powder preparation for external application is prepared from the following ingredients in parts by mass: prepared Sichuan aconite root, prepared wild aconite root, evodia, cinnamon, white mustard seed, schisandra fruit, psoralea fruit, rhizome of drynaria, achyranthes vine, borneol, vomic nut and wheat bran. All the ingredients for preparing the powder preparation are subjected to fine grinding together and are mixed uniformly, and the powder mixture is taken by 20g per time, is homogenized by using 10ml of alcohol and 10ml of vinegar, is spread in the middle of a gauze sandwich and is then applied to an affected part. The ingredients of the medicament are readily available in pharmacies, the powder preparation is prepared when the application is required, and the water preparation is simple to brew and convenient to take. The medicament has the advantages of good treatment effect and difficulty in recurrence; and shown by clinical use, the treatment effect is quick, the cure rate reaches up to 90%, and the recurrence is rare.
Inadequate dosing or discontinuation of treatment may lead to hyperglycemia and, in patients with type 1 diabetes, diabetic ketoacidosis. The first symptoms of hyperglycemia usually occur gradually over a period of hours or days. They include nausea, vomiting, drowsiness, flushed dry skin, dry mouth, increased urination, thirst and loss of appetite as well as acetone breath. Untreated hyperglycemic events are potentially fatal.

LEVEMIR is not intended for intravenous or intramuscular administration. The prolonged duration of activity of insulin detemir is dependent on injection into subcutaneous tissue. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycemia. Absorption after intramuscular administration is both faster and more extensive than absorption after subcutaneous administration.

LEVEMIR should not be diluted or mixed with any other insulin preparations (see PRECAUTIONS, Mixing of Insulins).

Insulin may cause sodium retention and edema, particularly if previously poor metabolic control is improved by intensified insulin therapy.

Lipodystrophy and hypersensitivity are among potential clinical adverse effects associated with the use of all insulins.

As with all insulin preparations, the time course of LEVEMIR action may vary in different individuals or at different times in the same individual and is dependent on site of injection, blood supply, temperature, and physical activity.

Adjustment of dosage of any insulin may be necessary if patients change their physical activity or their usual meal plan.
Patients randomized to the PVC-RAM-2 intervention will take biophysical measurements with the RAM technology and complete a daily recovery survey for 14 days after index hospital discharge, and nurses will review these results daily. Through scheduled video visits, patients will virtually interact with a nurse on days 1, 3, 7 and 14, and a physician on days 1 and 14. Patients will take a photograph of their wound daily for the first 7 days on the program, and nurses will review these pictures. If the patient's RAM measurements exceed predetermined thresholds, the patient reports specific symptoms (e.g., shortness of breath), a drug error is identified, or the virtual nurse has concerns about the patient's health that they cannot resolve, they will escalate care to a pre-assigned and available physician. Two 7-day extensions to the intervention will be possible, based on the patient's need for continued support. This decision will be based on standardized criteria.
Background and Objectives: Timor‑Leste is a lower‑middle‑income country in Southeast Asia. To control the significant local threat from infectious diseases, it is imperative to strengthen the knowledge and practice capabilities of the primary care workforce. Methods: We report and reflect on the development and delivery of a national training programme in infectious diseases called the Advancing Surveillance and Training to Enhance Recognition of Infectious Diseases (ASTEROID) programme, developed by the medical non‑governmental organisation (NGO) Maluk Timor and other Timorese stakeholders. The 1-week training course delivered by local doctors is multi‑modal, combining lectures with educational videos, interactive sessions and a mobile application. The ongoing training was delivered to every Timorese municipality in the participants' place of work and involved 540 healthcare professionals from 37 facilities. Training covered infectious diseases most relevant to the Timorese workforce, and focused on disease detection, management, prevention (including infection prevention and control issues) and notification. Findings: Multiple choice question (MCQ) assessment during the training has shown an average improvement in test scores from 45% to 64%, improving to 71% and 79% at 3- and 12-month follow‑up respectively. The programme has been well‑received, with participants appreciating the use of local specialists in video content, the tailoring of content to the local context and the variety of educational methods. Difficulties have been faced when it comes to delivering adequate content in a week‑long format to a workforce which has not previously received significant professional development. Conclusions: This approach could provide a model for delivering training to national healthcare workforces in low- and middle‑income countries (LMIC) and could be further refined on the basis of the lessons detailed here.
The invention discloses a cefazolin sodium compound prepared according to a novel intelligent crystallization technology and a preparation of the cefazolin sodium compound. 'Research, development and industrialization projects of high-end medical product refined crystallization technologies' won second prize of 2015th National Science and Technology Progress Award, and the novel intelligent crystallization technology is among the high-end medical product refined crystallization technologies. The cefazolin sodium compound is determined through X-ray powder diffraction, and main characteristic peaks represented by diffraction angles 2theta in an atlas are 12.24+-0.2 degrees, 16.23+-0.2 degrees, 18.94+-0.2 degrees, 19.26+-0.2 degrees, 19.80+-0.2 degrees, 20.61+-0.2 degrees, 21.05+-0.2 degrees and 23.57+-0.2degrees. Cefazolin sodium is recrystallized by combining a supercritical fluid extraction technology with a traditional crystallization technology. In a whole crystallization system, the process including extraction, adsorption, crystallization and drying is completed to recrystallize the cefazolin sodium at a specific temperature and at specific pressure under the joint action of supercritical fluid, a solvent, an extraction pond and a crystallizing pond. The preparation technology is high in separation efficiency with few impurities, so that preparation product quality is greatly improved.
The present invention relates to veterinary medicine. An extra-renal blood purification procedure is performed to remove toxins from the blood. Measuring baseline parameters of urea and creatinine in serum during blood purification; the Dialytic Intensity Index (DII), i.e. the ratio of the total volume of the body fluid of the diseased animal to the volume of the fluid cleared of toxins, and the Uremic Toxin Accumulation Index (UTAI), i.e. the rate of urea or creatinine accumulation per unit time, are determined based on the data obtained. Furthermore, if the UTAI value of urea is greater than 0.5, and/or the UTAI value of creatinine is greater than 8, and/or the DII value is less than 0.9, then it is deemed necessary to repeat hemodialysis. In particular, to prevent thrombosis, the animal was intravenously infused with the anticoagulant dalteparin sodium at a dose of 35 IU/kg body weight, followed by intravenous drip of dalteparin sodium at 15 IU/kg/h. With this method, UTAI values for urea and creatinine can be determined during dialysis intervals, changes in renal filtration capacity observed, and a prediction made as to whether hemodialysis should be repeated; the life expectancy of the animals can be significantly increased using the procedure described above.
Participants from clinics randomized to PL will get the patient smartphone app; clinic staff will receive the provider portal and provider smartphone app, the provider online LMS (learning management system), and the research assistant will use the administrative website to enroll participants. Patients randomized to PL will use it for 12 months or more; they can opt to use it as long as it is available during the study(access depending on enrollment date).
BACKGROUND: Chronic Kidney Disease (CKD) patients encounter many obstacles that affect their physical and psychological well-being. The primary objective of the present study was to investigate potential correlates of optimism/pessimism in a sample of patients with CKD, including socio-demographics, body appreciation and disordered eating symptoms. As a secondary objective, we proposed to examine the psychometric properties of an Arabic translation of the Optimism-Pessimism Short Scale-2 (SOP2) before its use in our sample.
METHODS: A cross-sectional study was carried out between April and May 2023, enrolling 108 participants from three hospitals in Lebanon providing insights into their sociodemographic characteristics, physical activity levels, body appreciation, optimism, pessimism, and eating attitudes.
RESULTS: Results indicated that the Arabic-language adaptation of the SOP2 has good reliability coefficients. The two facets of the scale displayed a strong correlation to each other, and highly similar correlations with external study variables (i.e., household crowding index, physical activity, body appreciation, disordered eating), suggesting that the SOP2 can be interpreted as a unidimensional measure for the psychological dispositional optimism as proposed by the developers. Furthermore, findings revealed a strong positive correlation between body appreciation and optimism, suggesting that CKD patients who appreciate their bodies tend to exhibit a more optimistic outlook on life. Conversely, higher body appreciation is associated with lower pessimism, indicating that a positive body image may mitigate feelings of hopelessness and despair in CKD patients.
CONCLUSION: This study contributes to the literature in two ways. First, it offers the Arabic SOP2 as an brief tool to administer, and psychometrically sound instrument that can be useful for clinical and research purposes. Second, it unveils a clear correlation between higher body appreciation and a more optimistic, less pessimistic mindset in patients with CKD.
EmoLED Group will be visited once a week. Therapy in this case includes, in addition to the standard therapy, a treatment with EmoLED device; it consists in irradiating each 5 cm diameter area of the lesion for 60 seconds, with the blue light emitted by the device. For lesions larger than 5 cm, several applications will be applied on adjacent areas, until the whole lesion is covered.
With the patient sitting upright in bed or a chair, the remote ischemic conditioning intervention will consist of 4 automatic cycles of upper arm blood pressure cuff inflation to 200 mm Hg for 5 minutes to induce transient, noninjurious, limb ischemia, followed by cuff deflation for 5 minutes, for a total of 35 minutes (autoRIC®, Cellaegis Devices, Mississauga, ON, Canada). The remote ischemic preconditioning cycles will be performed by trained research personnel prior to each cycle of chemotherapy (total treatments variable based on chemotherapy protocol).
Current body mass index (BMI) cutoff points (≥ 30 kg/m2) underestimate obesity prevalence in older adults. The aim of the present study was to propose new BMI cutoff points for identifying obesity in older Hispanic adults. In this study, new internally derived (ID) BMI cutoff point for obesity in older Hispanic adults was developed by analyzing data from the National Health and Nutrition Survey of 2018-2019 from Mexico. To evaluate the performance/validation of this newly proposed cutoff point, data from the "Study of the 1000", conducted in Northern Mexico, was utilized. Sensitivity, and negative predictive value (NPV) were assessed using receiver operating characteristic analysis, with obesity defined by fat mass index (FMI; ≥ 9.0 kg/m2 for men and ≥ 12.0 kg/m2 for women) as the reference method. The newly proposed ID BMI cutoff point was ≥ 27.2 kg/m2 which demonstrated high sensitivity (≥ 99.4%) and NPV (≥ 99.5%) in the total sample. Furthermore, the prevalence of obesity estimated by the new BMI cutoff point was comparable to that estimated by the FMI. The newly proposed BMI cutoff point provides a more accurate identification of obesity in older Hispanic adults. These findings have implications for improving obesity diagnosis and management in this population.