anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A pharmaceutical composition containing bis-(2-ethylhexyl) phthalate for anti-cancer is provided to suppress activation of Akt protein in cancer cells and suppress cancer cell proliferation. CONSTITUTION: An anti-cancer composition contains bis-(2-ethylhexyl) phthalate of chemical formula 1. The composition suppresses cancer cell proliferation and induces apoptosis. The bis-(2-ethylhexyl) phthalate is isolated from Aeromonas hydrophila. A method for isolating bis-(2-ethylhexyl) phthalate comprises: a step of extracting Aeromonas hydrophila culture medium using solvent; a step of filtering and concentrating; and a step of isolating through chromatography. The solvent is alcohol including methanol, ethanol, isopropanol, and ethyleneglycol, and halogen-substituted hydrocarbon including methylene chloride, chloroform, and carbon tetrachloride.
PURPOSE: To create a simple model using standard BI-RADS® descriptors from pre-treatment B-mode ultrasound (US) combined with clinicopathological tumor features, and to assess the potential of the model to predict the presence of residual tumor after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients.
METHOD: 245 female BC patients receiving NAC between January 2017 and December 2019 were included in this retrospective study. Two breast imaging fellows independently evaluated representative B-mode tumor images from baseline US. Additional clinicopathological tumor features were retrieved. The dataset was split into 170 training and 83 validation cases. Logistic regression was used in the training set to identify independent predictors of residual disease post NAC and to create a model, whose performance was evaluated by ROC curve analysis in the validation set. The reference standard was postoperative histology to determine the absence (pathological complete response, pCR) or presence (non-pCR) of residual invasive tumor in the breast or axillary lymph nodes.
RESULTS: 100 patients (40.8%) achieved pCR. Logistic regression demonstrated that tumor size, microlobulated margin, spiculated margin, the presence of calcifications, the presence of edema, HER2-positive molecular subtype, and triple-negative molecular subtype were independent predictors of residual disease. A model using these parameters demonstrated an area under the ROC curve of 0.873 in the training and 0.720 in the validation set for the prediction of residual tumor post NAC.
CONCLUSIONS: A simple model combining standard BI-RADS® descriptors from pre-treatment B-mode breast US with clinicopathological tumor features predicts the presence of residual disease after NAC.
Collagenase clostridium histolyticum will be used to treat participants in this arm of the study. Affected cords will be treated with 1-3 collagenase injections at 4 week intervals, based on clinical response of the contracture. Cords will be treated until motion of the joint is within 0-5 degrees of normal, for up to 3 total injections. Metacarpophalangeal cords will be injected with 0.58mg (10 000 units) of collagenase in 0.25ml of sterile diluent. Proximal interphalangeal cords will be injected with 0.58mg (10 000 units) of collagenase in 0.20ml of sterile diluent.
The investigators will test the efficacy of our proposed intervention to reduce embodied stress in four racial/ethnic groups (Black, Latinx, Pilipinx, and Pacific Islander) as a preventative intervention for health disparities found in these communities. The intervention is comprised of two phases. The first consists of community nature walks in a pristine redwood forest for six months. This is followed by chosen nature activities with family and/or friends for three months. The investigators will test the ability of these activities in nature to reduce chronic stress that underpins many health disparities using validated biological, behavioral, and sociocultural measures. The use of these measures is in alignment with the National Institute of Minority Health and Health Disparities (NIMHD) Research Framework, and will increase understanding of individual, interpersonal, community, and social level factors that lead to, and that can eliminate health disparities.
Aging is a life phenomenon that occurs in most living organisms and is a major risk factor for many diseases, including cancer. Cellular senescence is a cellular trait induced by various genomic and epigenetic stresses. Senescent cells are characterized by irreversible cell growth arrest and excessive secretion of inflammatory cytokines (senescence-associated secretory phenotypes, SASP). Chronic tissue microinflammation induced by SASP contributes to the pathogenesis of a variety of age-related diseases, including cancer. Senolysis is a promising new strategy to selectively eliminate senescent cells in order to suppress chronic inflammation, suggesting its potential use as an anticancer therapy. This review summarizes recent findings on the molecular basis of senescence in cancer cells and senolysis.
Thirty HCC patients (24 male, 6 females) Child A cirrhotics with branch PVT. Follow up was done at 1, 3, 6 and 12 months after first TACE. All patients underwent laboratory investigations including liver function tests to assess deterioration in liver functions, triphasic spiral CT to assess radiological response according to mRECIST criteria. Survival analysis was performed using Kaplan-Meier estimations.
The purpose of this study is to assess the effectiveness of an interdisciplinary intensive therapy program for ambulatory and non-ambulatory children with neurodevelopmental disorders across the ICF and to explore caregiver experiences and perspectives of the program. Research questions include: 1.) What are the effects of an intensive program on postural control and functional mobility for children with neurodevelopmental disorders? 2.) What are the effects of an intensive therapy program on dual tasking for children with neurodevelopmental disorders? 3.) What are the perceptions of caregivers of a multidisciplinary intensive therapy program for their children with neurodevelopmental disorders? Data will be gathered before and after the intensive program as part of usual care and ambulatory children will be further assessed in the motion analysis lab. Caregivers will complete a questionnaire about satisfaction with services and also a 4 question open-ended question survey about their experience with intensive therapy.
PICO14 device from Smith and Nephew. It is a Single-Use Negative Pressure Wound Therapy Device that provides an effective negative pressure of -80 mmHg for 14 days. It is an easily applied all-in-one system that ensures uniform application each time it is applied. The dressing consists of 4 distinct layers that reduce the risk of skin trauma, applies equal negative pressure to the skin and manages fluid transport away from the wound through a combination of absorption and evaporation through an airlock layer. The device is approved for the treatment of open wounds, closed surgical incisions and skin grafts. Both PICO-VAC and soft dressing are applied immediately postoperatively and removed after 12 days.
BACKGROUND: Menopause is typically accompanied by significant systemic and oral manifestations, including hormonal changes and increased susceptibility to periodontal disease, which may involve inflammatory biomarkers like aspartate aminotransferase (AST) and osteocalcin in gingival crevicular fluid (GCF). The study is aimed at evaluating the effectiveness of regular inoculation of polyunsaturated fatty acids (PUFAs) as an adjunctive treatment for menopausal women's periodontitis.
METHODS: Twenty elderly women with chronic periodontitis were split evenly into two groups by random assignment. Patients in group II (the research group) were given soft gelatin capsules containing PUFAs to be consumed directly once daily for 12 months, as opposed to group I (the control group), who received soft gelatin capsules containing some olive oil (placebo). Scaling and root planning (SRP) were used to address periodontal disease in all cases.
RESULTS: At baseline, six and twelve months after treatment, clinical indicators and AST and osteocalcin amounts in the GCF were noted. By the conclusion of the research period, all observed clinical measurements had changed significantly and improved. In addition, there had been a significant decrease in AST levels and a nonsignificant decrease in osteocalcin levels in group II compared to group I.
CONCLUSIONS: Menopausal women with periodontitis who take omega-3 fatty acid supplements in addition to SRP have better oral health. Significant improvements in clinical indicators and a notable decrease in AST levels within the GCF were observed. However, further research with larger cohorts and extended duration is needed to validate these findings and explain potential mechanisms. This trial is registered with NCT06254118.
BACKGROUND: Several studies indicate that people who stutter show greater variability in speech movements than people who do not stutter, even when the speech produced is perceptibly fluent. Speaking to the beat of a metronome reliably increases fluency in people who stutter, regardless of the severity of stuttering.
OBJECTIVES: Here, we aimed to test whether metronome-timed speech reduces articulatory variability.
METHOD: We analysed vocal tract MRI data from 24 people who stutter and 16 controls. Participants repeated sentences with and without a metronome. Midsagittal images of the vocal tract from lips to larynx were reconstructed at 33.3 frames per second. Any utterances containing dysfluencies or non-speech movements (e.g. swallowing) were excluded. For each participant, we measured the variability of movements (coefficient of variation) from the alveolar, palatal and velar regions of the vocal tract.
RESULTS: People who stutter had more variability than control speakers when speaking without a metronome, which was then reduced to the same level as controls when speaking with the metronome. The velar region contained more variability than the alveolar and palatal regions, which were similar.
CONCLUSIONS: These results demonstrate that kinematic variability during perceptibly fluent speech is increased in people who stutter compared with controls when repeating naturalistic sentences without any alteration or disruption to the speech. This extends our previous findings of greater variability in the movements of people who stutter when producing perceptibly fluent nonwords compared with controls. These results also show, that in addition to increasing fluency in people who stutter, metronome-timed speech also reduces articulatory variability to the same level as that seen in control speakers.
The application of a 5% topical lidocaine gel to one of the identified areas within the participants mouth using a microneedle patch. The microneedle patch will be applied to the oral mucosa of the identified site for 3 minutes, followed by infiltration with local anaesthetic to one of the identified areas within the participants mouth.
The invention relates to the field of biochemistry, in particular to an enzyme coexpression system and application thereof in sialic acid synthesis. The invention provides an N-acetylneuraminic acid aldolase (NAL) mutant which has an amino acid sequence shown as SEQ ID NO. 1; or a sequence in which 1 or more amino acids are substituted, deleted, added and/or substituted on the basis of the above amino acid sequence; or a sequence having a homology of 90% or more with the above amino acid sequence. The co-expression system of the double promoters adopted by the invention adopts a molecular biology means for increasing expression, realizes simultaneous over-expression of two enzymes, and realizes one-time bacteria breaking process to prepare enzyme liquid, thereby improving the reaction efficiency of enzyme catalytic reaction. Meanwhile, for Clostridium difficile: ( Clostridium scindens ) The NAL is modified, so that the synthesis efficiency of sialic acid produced by forward reaction is improved. The yield of the enzyme catalysis process in the invention meets the requirement of industrial production.
AIM OF STUDY: The study aims to assess the growing public health threat posed by Oropouche virus (OROV), focusing on its epidemiology, transmission patterns, and the challenges in diagnosis and control. By analyzing the recent spread of OROV to new regions, including Cuba and Colombia, the study seeks to highlight the need for improved surveillance, enhanced diagnostic capabilities, and research into potential treatments and vaccines. Additionally, the study investigates the clinical similarities between Oropouche fever and other arboviruses, which often lead to diagnostic difficulties and mismanagement in affected regions.
RESULTS: The virus has caused over 500,000 cases in Brazil alone, with recent outbreaks reporting fatalities, suspected vertical transmission, and potential associations with microcephaly in newborns. Underreporting and limited surveillance have likely led to the underestimation of the true burden of Oropouche fever. Current diagnostic methods, such as serology and RT-PCR, are often inaccessible in low-resource settings, further complicating efforts to control the spread of the virus. The study highlights the importance of improving diagnostic capacity, enhancing surveillance, and conducting further research into vector control, antiviral treatments, and vaccine development.
CONCLUSION: This study emphasizes the urgent need for coordinated international efforts to address the rising threat of Oropouche virus. Considering its rapid spread and potential for global transmission, comprehensive public health measures are necessary to protect vulnerable populations and mitigate the impact of this emerging disease. Enhanced surveillance and the development of accessible diagnostics, vaccines, and treatment options are critical to containing OROV and preventing further outbreaks.
The present invention relates to the extracting method of a kind of Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti phenolic compound, pulverize including by dry Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti, obtain Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti dry powder；Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti dry powder is soaked with ethanol water；Mixture after soaking carries out supersound process；Mixture after ultrasonic is filtered, obtains the first filter liquor and the first filtering residue；First filtering residue is scattered in ethanol water, filters after supersound process, obtain the second filter liquor and the second filtering residue；Second filtering residue is scattered in ethanol water, filters after supersound process, obtain the 3rd filter liquor and the 3rd filtering residue；First filter liquor, the second filter liquor and the 3rd filter liquor are merged, obtains extracting solution；By extracting solution concentrating under reduced pressure, obtain concentrated solution；Concentrated solution is dried.According to the extracting method of a kind of Hylotelephium erythrostictum (Miq.) H.Ohba Herba hylotelephii erythrosticti phenolic compound that the present invention provides, process is simple, extracts content high, effectively raises the extraction efficiency of phenolic compound, have good using value.
OBJECTIVES: Acute pancreatitis (AP) has a high incidence of hospitalizations, morbidity, and mortality worldwide. A growing number of studies on AP pathogenesis are based on cerulein-induced experimental model, which simulates human AP in vivo. It has been demonstrated that both pancreatic acinar cells and peritoneal macrophages are involved in pancreatic inflammation and damage. However, their connection has not been well understood.
METHODS: A cerulein-induced AP model was established on the pancreatic acinar cell line AR42J. Rat macrophages were isolated from the peritoneal cavity. The effects of cerulein-induced pancreatic exosomes on the peritoneal macrophage and pancreas in vivo and in vitro were examined. The underlying molecular mechanism was investigated by exploring the regulatory role of downstream molecules.
RESULTS: We found that exosomes derived from cerulein-treated AR42J cells induced rat peritoneal macrophage M1 polarization and pyroptosis. miR-24-3p was upregulated in cerulein-stimulated exosomes, whereas the miR-24-3p inhibitor counteracted the effect of pancreatic exosomes on peritoneal macrophage M1 polarization and pyroptosis. Furthermore, miR-24-3p inhibited March3 expression, whereas MARCH3 mediated NLRP3 ubiquitination in rat peritoneal macrophages, which, in turn, contributed to the apoptosis, reactive oxygen species production, and inflammation in AR42J cells.
CONCLUSIONS: Exosomes derived from cerulein-stimulated pancreatic acinar cells mediate peritoneal macrophage M1 polarization and pyroptosis via an miR-24-3p/MARCH3/NLRP3 axis in AP.
In animal studies with olanzapine, the principal hematologic findings were reversible peripheral cytopenias in individual dogs dosed at 10 mg/kg (17 times the daily oral MRHD based on mg/m 2body surface area), dose-related decreases in lymphocytes and neutrophils in mice, and lymphopenia in rats. A few dogs treated with 10 mg/kg developed reversible neutropenia and/or reversible hemolytic anemia between 1 and 10 months of treatment. Dose-related decreases in lymphocytes and neutrophils were seen in mice given doses of 10 mg/kg (equal to 2 times the daily oral MRHD based on mg/m 2body surface area) in studies of 3 months' duration. Nonspecific lymphopenia, consistent with decreased body weight gain, occurred in rats receiving 22.5 mg/kg (11 times the daily oral MRHD based on mg/m 2body surface area) for 3 months or 16 mg/kg (8 times the daily oral MRHD based on mg/m 2body surface area) for 6 or 12 months. No evidence of bone marrow cytotoxicity was found in any of the species examined. Bone marrows were normocellular or hypercellular, indicating that the reductions in circulating blood cells were probably due to peripheral (non-marrow) factors.
Consecutive civilian trauma survivors will be contacted, by phone, within five days of admission to Hadassah University Hospital in Jerusalem and asked about their early psychological responses to the event. A short telephone interview will be administered to consenting subjects, to evaluate the presence of acute stress disorder (ASD). Subjects with ASD (full or partial) and those who so desire will be invited to clinical assessment, which will take place within the next two weeks. Survivors with significant symptoms of post-traumatic stress disorder will be randomized to five arms of twelve-week long treatment: CBT, CT, SSRI/placebo and waiting list (WL) and start treatment immediately. Subjects will be allowed to decline one form of therapy. WL subjects will start therapy 12 weeks later. All subjects who had clinical interview will be interviewed again at four and seven months - and 14 months following trauma (phone interview).
An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAm) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ. Methods are given for delivering Phenstatin to a cancerous tumor. In these methods, the drug delivery system is injected into a tissue or into a tumor where it forms a gel. Phenstatin is slowly released from the polymer and exerts its cytotoxic, tublin-related effects on the tumor. Tumors that may be treated by the present methods include, but are not limited to breast, prostate, lung and bowel cancerous tumors.
PLAYwithHEART Programme is a manualized mindfulness, acceptance, and compassionate-based group intervention for adolescent competitive athletes. It included 8 weekly group sessions, 45 minutes each, run in small groups (ranging from 8 to 12 participants). Participants of this group complete also self-report measures.
In Uganda, participants will receive management per Uganda Ministry of Health (MOH) guidelines. A reflex genotypic resistance test (GRT) is performed by MOH for individuals with a second viral load \>1,000 while on TLD. Participants will continue enhanced adherence counseling (EAC) and TLD while awaiting the GRT result. Participants will have an additional Week 24 visit for specimen collection. Participants will return for a visit after GRT results are received and a treatment decision has been made by the regional switch committee. In South Africa, participants will receive management per South Africa Department of Health guidelines. At enrollment, participants will undergo EAC and continue on TLD. At Week 24, participants will undergo repeat viral load testing. If viral load \>1,000, the participant will continue TLD and EAC. If resuppressed, participants will be maintained on TLD. All participants will undergo plasma HIV-1 RNA viral load testing at Week 48.
Progression of knee cartilage degenerative changes leads to necessary total knee arthroplasty in future, which is the most popular procedure for treating OA. HTO applied at early stages of osteoarthritis allow slow down cartilage degeneration process, but the choice of performed surgery depends on surgeons personal assessment. Patellofemoral Pain Syndrome often occurs with knee arthritis. Antero-medialisation of tibial tubercle is frequent procedures for patella maltracking. So far, both, HTO and Fulkerson osteotomy was performed separately, even if patient have symptoms from patellofemoral joint and OA. The investigators believe that simultaneously surgery of HTO and fulkerson Osteotomy provides better outcomes and significantly slow down knee degeneration.
OBJECTIVES: The changes of the extracellular matrix of the connective tissue have significantly contributed to the incidence of pelvic organ prolapse (POP). It seems reasonable that sonoelastography could be a useful tool to evaluate the elasticity of pelvic floor tissue in patients with POP and compare it to those without POP. The main aim of this pilot study was to determine if there are differences in the elasticity of the levator ani muscle (LAM) and vaginal tissue between patients with and without POP.
METHODS: Prospective observation study, including 60 patients (30 with POP and 30 without POP). Sonoelastography was performed to evaluate the elasticity (in kilopascals, kPa) of the following regions of interest: vagina at the level of middle third of the urethra; vagina at the level of the bladder trigone; vagina in the anterior and posterior fornix; vagina at the level of middle third of the anorectal canal; posterior third of the LAM.
RESULTS: A total of 60 patients completed the study (30 with POP, 30 without POP). In the POP group, 18/30 (60%) had an anterior vaginal wall prolapse, 3/30 (10%) a uterine prolapse, 15/30 (50%) a rectocele, and 6/30 (20%) a enterocele. Patients with POP had higher elasticity in all anatomical study areas, with statistically significant differences in the anterior fornix (13.6 vs 11.2 kPa; P: .012). A multiple regression (controlling age, menopausal stage, and parity) allowed to detect statistically significant differences in the elasticity of the middle third of the urethra (P: .03) and the middle third of the anorectal canal (P: .019).
CONCLUSION: It is possible to evaluate the elasticity of the LAM and vaginal tissue using sonoelastography, detecting a higher elasticity in patients with POP than in those without POP.