anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1520819 Protein hydrolysate H J ROBERTSON 3 Aug 1976 [10 May 1976] 32302/76 Heading C3H A therapeutic agent comprises a non-antigenic protein hydrolysate containing polypeptides and amino acids obtained by: commingling the feet of young freshly killed poultry or the feet of other young freshly killed animals (other than human beings) with a dilute organic acid solution containing 1-1À5% by weight of acid at an elevated temperature up to 155‹ F., removing the fat constituent and removing the solubilized protein and dissolved minerals at the elevated temperature. By the feet of young freshly killed poultry or the feet of other young freshly killed animals (other than human beings) are meant feet of poultry and animals that are sufficiently young that the resulting protein substantially lacks antigenic properties and that the feet are in prime or undeteriorated condition. The said poultry feet may be obtained from chickens not more than 9 weeks old whilst the organic acid is preferably acetic acid. The poultry feet may be ground and pretreated with an organic acid at 70-90‹ F. The fat removing step preferably includes cooling the solution and separating out the fat layer. The agent may be in the form of a dehydrated gel which is obtained by reheating the cooled solution, after removal of the fat, and subsequently air drying the reheated solution. Alternatively the agent may be a powder which is obtained by spray drying the resultant solution from which the fat material has been removed. In an Example specific percentages of the following aminoacids, as making up the material of the invention, are specified: Asp, Glu, His, Lys, Arg, HLys, HPro, Thr, Se, Tyr, Gly, 2Cys, Pro, Al, Va, Met, leu, ileu, Phe.
Emerging evidence suggests that the gut microbiota is closely related to psychiatric disorders. However, little is known about the role of the gut microbiota in the development of obsessive-compulsive disorder (OCD). Here, to investigate the contribution of gut microbiota to the pathogenesis of OCD, we transplanted fecal microbiota from first-episode, drug-naive OCD patients or demographically matched healthy individuals into antibiotic-treated specific pathogen-free (SPF) mice and showed that colonization with OCD microbiota is sufficient to induce core behavioral deficits, including abnormal anxiety-like and compulsive-like behaviors. The fecal microbiota was analyzed using 16 S rRNA full-length sequencing, and the results demonstrated a clear separation of the fecal microbiota of mice colonized with OCD and control microbiota. Notably, microbiota from OCD-colonized mice resulted in injured neuronal morphology and function in the mPFC, with inflammation in the mPFC and colon. Unbiased metabolomic analyses of the serum and mPFC region revealed the accumulation of succinic acid (SA) in OCD-colonized mice. SA impeded neuronal activity and induced an inflammatory response in both the colon and mPFC, impacting intestinal permeability and brain function, which act as vital signal mediators in gut microbiota-brain-immune crosstalk. Manipulations of dimethyl malonate (DM) have been reported to exert neuroprotective effects by suppressing the oxidation of accumulated succinic acid, attenuating the downstream inflammatory response and neuronal damage, and can help to partly improve abnormal behavior and reduce neuroinflammation and intestinal inflammation in OCD-colonized mice. We propose that the gut microbiota likely regulates brain function and behaviors in mice via succinic acid signaling, which contributes to the pathophysiology of OCD through gut-brain crosstalk and may provide new insights into the treatment of this disorder.
Some patients with metastatic prostate cancer carry a pathogenic germline variant (PV) in a gene, that is mainly associated with an increased risk of breast cancer in women. If they test positive for such a PV, prostate cancer patients are encouraged to disclose the genetic test result to relatives who are at risk in case the carrier status changes the relatives' medical care. Our study aimed to investigate how men who learned they carry a PV in BRCA1, BRCA2, PALB2, CHEK2 or ATM disclosed their carrier status to at-risk relatives and to assess the possible psychological burden for the carrier and their perception of the burden for relatives. In total, 23 men with metastatic prostate cancer carrying a PV completed the IRI questionnaire about family communication; 14 also participated in a semi-structured interview. Patients felt highly confident in discussing the genetic test result with relatives. The diagnosis of prostate cancer was experienced as a burden, whereas being informed about genetic testing results did in most cases not add to this burden. Two patients encountered negative experiences with family communication, as they considered the genetic test result to be more urgent than their relatives. This mixed-methods study shows that metastatic prostate cancer patients with a PV in genes mainly associated with increased risk of breast cancer feel well-equipped to communicate about this predisposition in their families. Carriers felt motivated to disclose their genetic test result to relatives. Most of them indicated that the disclosure was not experienced as a psychological burden.
FIELD: cosmetology. SUBSTANCE: invention deals with cosmetic compositions containing in cosmetically acceptable aqueous medium: a polysaccharide and a triple acryl copolymer and, also, the method for treating keratin materials. A triple acryl copolymer contains: (a) about 20-70 wt.% carboxylic acid with α,β- monoethylene saturation; (b) about 20- 80 wt.% monomer with monoethylene nonsaturation not revealing any surface-active properties being distinct against (a) component, and (c) about 0.5-60% nonionic urethan monomer being the product of reaction of nonionogenic monatomic SAS with monoisocyanate with monoethylene nonsaturation. Polysaccharide is represented by guar resin. Compositions reveal target viscosity, they are not paste-like ones and demonstrate good distribution along skin and hair by providing them softness and capacity to be well combed along with high fixing properties. EFFECT: higher efficiency. 21 cl
Under aseptic precautions 20 ml of venous blood was drawn and added to a test tube containing acid citrate dextrose in a ratio of 9:1 (blood: Acid citrate dextrose), centrifuged at 5000 rpm for 15 min to separate the red blood cells from the platelets and plasma. Then the supernatant and the buffy coat composed of platelets and plasma were collected and centrifuged again at 2000 rpm for 5-10 min. The bottom layer about 1.5 ml was taken and 10% calcium chloride was added (0.3 ml for 1 ml of PRP). Then the activated PRP was applied to the wound after proper surgical debridement and was dressed with a non-absorbent dressing (paraffin gauze). This process was repeated once weekly for 6 weeks.
The present invention belongs to the field of biologic medicine, and particularly relates to a superoxide dismutase conjugate and a preparation method thereof. The modification rate of free amino groups of superoxide dismutase on the conjugate is from 11.1% to 88.8%. The preparation method comprises: low molecular heparin activated by sodium periodate is used for modifying the free amino groups on the superoxide dismutase. The prepared conjugate has the characteristics of low antigenicity, long half life, high stability, etc.; the proper characteristics of thrombus resistance, inflammation relieving, microcirculatory promotion, etc. of the low molecular heparin can be fully exerted. The conjugate has the functions of preventing and curing reperfusion injury in ischemic cerebral apoplexy and can be used as an additive in cosmetics.
Drug: GamCovidVac-M vector vaccine for the prevention of COVID-19 with altered antigenic composition. A total of 50 people will be randomized and receive the study drug. Two intramuscular injections of GamCovidVac-M vector vaccine for the prevention of COVID-19 with altered antigenic composition will be performed. 1st injection - component I, 2nd injection - component II.
1,158,725. Process for N-carboxyanhydrides of amino acids. MERCK & CO. Inc. 22 June, 1966 [24 Oct., 1965], No. 9279/69. Divided out of 1,158,721. Heading C2C. Hydroxylated N-carboxy amino acid anhydrides are prepared by reacting a metallic chelate of a hydroxylated α-amino acid with a transition metal with COCl 2 . Suitable amino acids are tyrosine, threonine, serine and hydroxyproline, and suitable metals are selected from Groups IB, IIB, IIIB and VIII of the Periodic Table. The process may be combined with one wherein the chelate is formed by reaction of a salt or base of the metal with the amino acid.
The Interrelationship Between Women's Involvement In Decision Making In Labor And Their Perception Of The Labor Experience Labor is one of the most significant events in women's lives. The process and outcome of labor may have long term effects on the way women perceive the parenting role and their personal, emotional and physical capability. Each woman arrives to labor with a planned construct of beliefs, expectations and fantasies regarding the labor process and outcomes, which are driven from different cultural values and personal beliefs. The clinical reality does not always correlate with this emotional construct and with a woman's anticipated level of involvement in decision making at labor. Discrepancy between women's desired or expected labor processes and what happens in actuality may have a substantial impact on women's lives and on the way they will experience future births. The main goal of this research is to investigate the effects of labor process on women by examining the question whether women's involvement in decision making during labor has an effect on their perceived labor process.

The perceived labor process is a combination of a woman's level of engagement in decision making at labor, her perceived level of control in the labor process and the level of satisfaction from the obstetric caregivers (gynecologists and midwives). The participants of this research project shall be comprised of 100 women who were hospitalized during the two days immediately following labor and delivery in the maternity unit at Hillel Yaffe hospital, who gave birth in a normal delivery, at term (37 weeks of gestation) with no surgical or instrumental intervention and had no complications either to them or their babies. The participants will be given a self-replying questionnaire constructed especially for the purposes of this research project. The questionnaire is comprised of seven parts: (1) social-demographic information,(2) health background,(3) obstetric background,(4) the woman's perspective of labor process in general,(5) the woman's perspective of the progression of her actual labor,(6) the woman's evaluation of the attitude of obstetric caregivers (gynecologists and midwives) and (7) the level of control the woman had in decision making during labor and her perception of the labor experience. The research findings will be analyzed statistically using Statistical Package for the Social Sciences (SPSS) format. In addition to understanding the way women perceive their labor and delivery in terms of the level of involvement in decision making, these findings may also contribute to develop a therapeutic intervention tool to assist accommodating specific treatment to women in labor and childbirth according to the level of her desired involvement in decision making at birth, her viewpoint of therapeutic intervention and her expectations of the labor process.
The incidence of acute myocardial infarction is increasing in younger age groups, with differences in treatment and outcomes based on gender. ST-elevation myocardial infarction (STEMI) in young adults, however, is incompletely understood as most of the current studies were performed in homogenous populations, did not focus on STEMI, and lack direct comparisons with older adults. We performed a retrospective observational study using the Statewide Planning And Research Cooperative System for all admissions in New York State with a principal diagnosis of STEMI from 2011 to 2018. There were 58,083 STEMIs with the majority being male (68.2%) and non-Hispanic White (64.8%), with an average age of 63.9 ± 13.9 years. Of these, 8,494 (14.6%) occurred in patients aged <50 years. The proportion of STEMIs in women increased with age, from 19.2% in the <50-year-old age group to 48.9% in the ≥70-year-old age group. Young adults with STEMI had greater prevalence of obesity, current tobacco use, other substance use, and major psychiatric disorders, were more likely to receive revascularization, and had lower 1-year mortality than older age groups. Revascularization was associated with at least a 3 times lower odds ratio of 1-year mortality in all age groups. In conclusion, young adults with STEMI had a unique set of risk factors and co-morbidities and were more likely to undergo revascularization than older age groups. In all age groups, female gender was associated with a higher burden of co-morbidities, decreased use of revascularization, and increased 1-year mortality.
Diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease and one of the significant complications of diabetes. This study aims to identify the main differentially expressed genes in DKD from transcriptome sequencing results and analyze their diagnostic value. The present study sequenced db/m mouse and db/db mouse to determine the ALOX12 genetic changes related to DKD. After preliminary validation, ALOX12 levels were significantly elevated in the blood of DKD patients, but not during disease progression. Moreover, urine ALOX12 was increased only in macroalbuminuria patients. Therefore, to visualize the diagnostic efficacy of ALOX12 on the onset and progression of renal injury in DKD, we collected kidney tissue from patients for immunohistochemical staining. ALOX12 was increased in the kidneys of patients with DKD and was more elevated in macroalbuminuria patients. Clinical chemical and pathological data analysis indicated a correlation between ALOX12 protein expression and renal tubule injury. Further immunofluorescence double staining showed that ALOX12 was expressed in both proximal tubules and distal tubules. Finally, the diagnostic value of the identified gene in the progression of DKD was assessed using receiver operating characteristic (ROC) curve analysis. The area under the curve (AUC) value for ALOX12 in the diagnosis of DKD entering the macroalbuminuria stage was 0.736, suggesting that ALOX12 has good diagnostic efficacy. During the development of DKD, the expression levels of ALOX12 in renal tubules were significantly increased and can be used as one of the predictors of the progression to macroalbuminuria in patients with DKD.
Busulfan may cause additive myelosuppression when used with other myelosuppressive drugs.

In one study, 12 of approximately 330 patients receiving continuous busulfan and thioguanine therapy for treatment of chronic myelogenous leukemia were found to have portal hypertension and esophageal varices associated with abnormal liver function tests. Subsequent liver biopsies were performed in 4 of these patients, all of which showed evidence of nodular regenerative hyperplasia. Duration of combination therapy prior to the appearance of esophageal varices ranged from 6 to 45 months. With the present analysis of the data, no cases of hepatotoxicity have appeared in the busulfan-alone arm of the study. Long-term continuous therapy with thioguanine and busulfan should be used with caution.

Busulfan-induced pulmonary toxicity may be additive to the effects produced by other cytotoxic agents.

The concomitant systemic administration of itraconazole to patients receiving high-dose MYLERAN may result in reduced busulfan clearance (see CLINICAL PHARMACOLOGY). Patients should be monitored for signs of busulfan toxicity when itraconazole is used concomitantly with MYLERAN.
PURPOSE:A composition useful in the field of cosmetic, drug, food, dye, etc., having improved storage stability to temperature and liht rays, containing aspartic acid, shikonin and/or its derivative. CONSTITUTION:A composition having improved storage stability to temperature and light, containing shikonin and/or its derivative, and aspartic acid in a weight ratio of (1:1)-(1:100). The use of shikonin and its derivative together with aspartic acid keeps beautiful color tone of shikonin or its derivative and medicinal effect. Shikonin and its derivative is usually obtained by extraction from cell of the root of Lithospermum officinale Linne var. erythrorhizon Maximowicz by callus cultivation method or the rhizome of it with an organic solvent such as ethanol, etc. and used. Aspartic acid is preferably L-form.
PURPOSE: A Streptomyces driven thrombolytic enzyme is provided to be used for thrombolytic agent by having a decomposing function without toxicity. CONSTITUTION: A Streptomyces driven thrombolytic enzyme is refined from Streptomyces SP. CS628 which has an accession number of KCTC18202p, and 2011.11.15. The Streptomyces driven thrombolytic enzyme is moved by SDS-PAGE as a single polypeptide corresponding to 17,600 Da. The maximum activation temperature is 50-55 deg. Celsius and the optimum PH is pH 8.0. The Streptomyces driven thrombolytic enzyme is most stable at pH 8.0-12.0 and under 40 deg. Celsius.
Tetrasomy 9p is a rare genetic syndrome resulting from two additional copies of the short arm of chromosome 9. Symptoms often present in the form of congenital abnormalities including cognitive disabilities, growth retardation, abnormal earlobes, congenital heart disease, and dysmorphia of the skull and face. Current literature suggests patients with tetrasomy 9p may exhibit any combination of these symptoms or, in rare instances, none at all. Although karyotyping, chromosomal microarray, and galactose-1-phosphate uridyltransferase activity analyses are the definitive diagnostic methods used, there remains a need for more robust clinical recognition in cases of mild phenotypic expression. Herein, we present a rare case of mosaic tetrasomy 9p in a long-term survival patient with multiple and recurrent pilomatrixomas, rare benign growths more commonly found in individuals under the age of 20. To our knowledge, only two previous reports have noted concurrent tetrasomy 9p with pilomatrixomas. We are the first to identify this phenotype in an adult tetrasomy 9p patient. Dermatopathology evaluation was conducted to verify our diagnoses. Our aim is to present a unique, additional case suggesting multiple pilomatrixomas as a new defining clinical presentation of mosaic tetrasomy 9p and to review the literature underlying the genetic changes associated with this syndrome.
Provided in the present invention are a preparation method for and the use of a CD70-specific integrated diagnosis and treatment molecular imaging probe. The probe comprises a tumor targeting group and radionuclides. The tumor targeting group is selected from a CD70-specific nanoantibody or a CD70-specific nanoantibody fusion protein, wherein the CD70-specific nanoantibody is B3 or B6, the amino acid sequences thereof being shown as SEQ ID NO. 1 and SEQ ID NO. 3, and the CD70 specific nanoantibody fusion protein is ABDB3 or ABDB6, the amino acid sequences thereof being shown as SEQ ID NO. 5 and SEQ ID NO. 7. The present invention achieves non-invasive visualization of human CD70 molecular expression and thus achieves noninvasive diagnosis of renal cell carcinoma. The probe has the advantages of simple preparation process, low cost, high specificity, high stability, short imaging period, low radiation dose, easiness in clinical conversion, etc.
A method for providing a medical second opinion includes receiving a first ICD-9 code from a physician at a computerized system. The first ICD-9 code is related to a clinical interest of the physician. A second ICD-9 code is received at the computerized system from a patient. The computerized system compares the first and second ICD-9 code values. By finding equivalent or equal ICD-9 codes, a physician having an appropriate clinical interest is automatically referred to the patient. The physician provides a second medical opinion.
A method for extracting the soluble calcium citrate by the manioc residue in a short period. The calcium citrate becomes more and more popular for the consumers as an ideal calcium supplement. The calcium citrate for sale in the market belongs to organic calcium, whose solubility is better than inorganic calcium and good for the absorption of human body to calcium, however, still belonging to the organic calcium with a low solubility, which restricts the absorption of human body to calcium. The inventive method mentioned above improves the absorption of the organic calcium and the mouthfeel by fermenting the manioc residue with Aspergillus niger. The produced organic calcium has a high solubility and tastes like lemon. The cost of the extracted soluble calcium citrate is equal to that of the citric acid with purity over 99.5%.
BACKGROUND: Detection of precachexia is important for the prevention and treatment of cachexia. However, how to identify precachexia is still a challenge.
OBJECTIVE: This study aimed to detect cancer precachexia using a simple method and distinguish the different characteristics of precachexia and cachexia.
METHODS: We included 3896 participants in this study. We used all baseline characteristics as input variables and trained machine learning (ML) models to calculate the importance of the variables. After filtering the variables based on their importance, the models were retrained. The best model was selected based on the receiver operating characteristic value. Subsequently, we used the same method and process to identify patients with precachexia in a noncachexia population using the same method and process.
RESULTS: Participants in this study included 2228 men (57.2%) and 1668 women (42.8%), of whom 471 were diagnosed with precachexia, 1178 with cachexia, and the remainder with noncachexia. The most important characteristics of cachexia were eating changes, arm circumference, high-density lipoprotein (HDL) level, and C-reactive protein albumin ratio (CAR). The most important features distinguishing precachexia were eating changes, serum creatinine, HDL, handgrip strength, and CAR. The two logistic regression models for screening for cachexia and diagnosing precachexia had the highest area under the curve values of 0.830 and 0.701, respectively. Calibration and decision curves showed that the models had good accuracy.
CONCLUSION: We developed two models for identifying precachexia and cachexia, which will help clinicians detect and diagnose precachexia.