anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Contrasting findings on the mechanisms of chronic pain and hypertension development render the current conventional evidence of a negative relationship between blood pressure (BP) and pain severity insufficient for developing personalized treatments. In this interdisciplinary study, patients with fibromyalgia (FM) exhibiting clinically normal or elevated BP, alongside healthy participants were assessed. Different pain sensitization responses were evaluated using a dynamic 'slowly repeated evoked pain' (SREP) measure, as well as static pain pressure threshold and tolerance measures. Cardiovascular responses to clino-orthostatic (lying-standing) challenges were also examined as acute re- and de-hydration events, challenging cardiovascular and cerebrovascular homeostasis. These challenges involve compensating effects from various cardiac preload or afterload mechanisms associated with different homeostatic body hydration statuses. Additionally, hair cortisol concentration was considered as a factor with an impact on chronic hydration statuses. Pain windup (SREP) and lower pain threshold in FM patients were found to be related to BP rise during clinostatic (lying) rehydration or orthostatic (standing) dehydration events, respectively. These events were determined by acute systemic vasoconstriction (i.e., cardiac afterload response) overcompensating for clinostatic or orthostatic cardiac preload under-responses (low cardiac output or stroke volume). Lower pain tolerance was associated with tonic blood pressure reduction, determined by permanent hypovolemia (low stroke volume) decompensated by permanent systemic vasodilation. In conclusion, the body hydration status profiles assessed by (re)activity of systemic vascular resistance and effective blood volume-related measures can help predict the risk and intensity of different pain sensitization components in chronic pain syndrome, facilitating a more personalized management approach.
At least one activity history for a plurality of entities is received. The at least one activity history comprises at least two events. An inter-event gap distribution is learned using the at least one activity history for the plurality of entities. A current activity history for a current entity is received. A probability of at least one of an onset and a termination related to the current activity history is determined based on the learned inter-gap distribution. An output is produced based on the determined probability.
The PMT was performed by the two physiotherapists using an OUTSO 06® Fascia Gun equipped with a 5 cm diameter soft attachment head. Throughout the PMT, the physiotherapists carefully maintained a consistent level of moderate pressure on the skin, and followed the direction of the muscle fibers. In the L-PMT group, the treatment was applied for 40 minutes.
Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent progression of OA. In this sense, detecting and quantifying synovitis of OA by imaging modalities may be valuable in predicting OA progressors as well as in improving our understanding of OA progression. Of the several imaging modalities, molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) has an advantage of visualizing the cellular or subcellular events of the tissues. Depending on the radiotracers used, molecular imaging method can potentially detect and visualize various aspects of synovial inflammation. This narrative review summarizes the recent progresses of imaging modalities in assessing inflammation and OA synovitis and focuses on novel radiotracers. Recent studies about imaging modalities including ultrasonography (US), magnetic resonance imaging (MRI), and molecular imaging that were used to detect and quantify inflammation and OA synovitis are summarized. Novel radiotracers specifically targeting the components of inflammation have been developed. These tracers may show promise in detecting inflamed synovium of OA and help in expanding our understanding of OA progression.
The invention belongs to the technical field of separation of plant active components, and relates to a separation method of anti-inflammatory active components of lycium ruthenicum fruits. At present, pharmacodynamic studies on lycium ruthenicum mill are mainly focused on anthocyanin, and no report is found on pharmacodynamic studies on other components. Therefore, the screening and separation of the anti-inflammatory active ingredients of the lycium ruthenicum have important significance for preventing and treating various diseases caused by inflammation. The invention is realized by the following technical scheme: 1) mixing the lycium ruthenicum fruit alcohol extract with polyamide powder; 2) separating the mixed powder with MCI open chromatographic column to obtain components Fr1, Fr2 and Fr 3; 3) separating the component Fr1 with macroporous resin column to obtain components Fr1-1 and Fr 1-2. Through establishing an LPS-induced RAW264.7 cell inflammation model and screening the anti-inflammatory activity of the obtained components, the active site Fr1-2 in the lycium ruthenicum fruit is found to have better anti-inflammatory effect. The invention provides a new method for separating anti-inflammatory components from lycium ruthenicum fruits.
The study aims to investigate the role of candidate biomarkers in the diagnosis and prognosis of AA and AD. In the diagnosis part, we begin with a discovery phase where individually matched case-control study. Patients within each disease outcomes (i.e. AD, AMI, PE, AA without AD and healthy controls) are age and sex matched and retrospectively included.In the prognosis part of the study, patients with confirmed AA and AD are enrolled. The primary outcome is the all-cause mortality based on the death certificates. The secondary outcome is the in-hospital mortality according to the patients'medical records.
PURPOSE:To provide an agent having slow and mild action to promote the production of nitrogen monoxide and applicable without inducing shock by the excessive depression of blood pressure. CONSTITUTION:This agent for promoting the production of nitrogen monoxide contains one or more kinds of crude drugs selected from KOJOKON (root of Polygonum reynoutria), OUGI (root of Astragalus huantchy), JASHOSHI (fruit of Cnidium monnieri), malt, SOHAKUHI (bark of Morus bombycis), nonglutinous rice, SANSHO (peel of Zanthoxylum schinifolium), FUHYOU (whole grass of Lemna polyrrhiza), KYOOU (rhizome of Curcuma aromatica), ENGOSAKU (rhizome of Corydalis turtschaninovii), BOREI (shell of Ostrea gigas), YAKUMOSOU (Whole grass of Leonurus sibiricus), SEIMOKKO (root of Aristolochia debilis), NINJIN (root of Panax ginseng) and OUGON (root of Scutellaria baicalensis) or their extract as active component. The crude drug extract can be prepared by adding 10-40 pts.wt. of a solvent to 1 pt.wt. of the crude drug and boiling for 10min to 2hr or boiling until the volume of the solvent is decreased to half and filtering the obtained extract liquid. The agent can be administered in the form of a peroral drug or a parenteral drug such as injection or an agent for drip transfusion. The amount of the agent for oral administration is about 1-10g in terms of the dried extract in l-3 divided doses. The agent has strong nitrogen monoxide production promoting action on vascular smooth muscle cell and macrophage.
PURPOSE: A composition containing Aster Subulatus Michx. extract, fraction or compound is provided to prevent oxidative stress and to prevent and treat cell oxidation. CONSTITUTION: A compound extracted and purified from Aster Subulatus Michx. is denoted by chemical formula 1. A method for preparing the compound comprises: a step of extracting Aster Subulatus Michx. with water, alcohol of C1-C3 or mixture solvent thereof to obtain Aster Subulatus Michx. extract; a step of fractioning the Aster Subulatus Michx. extract with water, n-hexane, methylene chloride, ethyl acetate, or n-butanol to obtain Aster Subulatus Michx. fraction; and a step of performing column chromatography. A composition for preventing and treating diseases caused by cell oxidation contains the compound of chemical formula 1 as an active ingredient.
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation and also for human and livestock health. The structures of infectious prions that cause CWD and other natural prion diseases of mammalian hosts have been poorly understood. Here we report a 2.8 Å resolution cryogenic electron microscopy-based structure of CWD prion fibrils from the brain of a naturally infected white-tailed deer expressing the most common wild-type PrP sequence. Like recently solved rodent-adapted scrapie prion fibrils, our atomic model of CWD fibrils contains single stacks of PrP molecules forming parallel in-register intermolecular β-sheets and intervening loops comprising major N- and C-terminal lobes within the fibril cross-section. However, CWD fibrils from a natural cervid host differ markedly from the rodent structures in many other features, including a ~ 180° twist in the relative orientation of the lobes. This CWD structure suggests mechanisms underlying the apparent CWD transmission barrier to humans and should facilitate more rational approaches to the development of CWD vaccines and therapeutics.
The invention discloses a fuming and washing type medicament for treating rheumatoid arthritis and a using method thereof. The fuming and washing type medicament is prepared from 14 herbal medicines according to proportions; stems of Chinese wisteria, dalbergia dyeriana, roots of montane baliospermum, roots or stems of commom epipremnum, roots or leaves of rourea microphylia Planch. and roots of sabia schumanniana Diels have the effects of warming tendons, dredging collaterals, promoting blood circulation to remove blood stasis, dispelling the wind and removing numbness and serve as monarch drugs; roots of euphorbia erythraea Hemsl., leaves of potts waxplant, all-grass of scutellaria orthocalyx Hand.-Mazz. and all-grass of dregea sinensis Hemsl. have the effects of clearing heat, removing toxicity and removing swellings and dampness and serve as minister drugs; rhizomes of buddleia davidii Franch. and roots and stem vines of clematis courtoisii Hand.Mazz. have the effect of narcotizing skin and serve as adjuvant drugs; bark of camphortree and roots and stems of dalbergia hancei Benth. have the effects of promoting qi circulation to relieve pain, relaxing muscles and tendons and destroying accumulation and serve as guide drugs; the medicament with the effects of warming the tendons, resolving lumps, activating the blood, removing blood stasis, dispelling the wind and promoting diuresis to eliminate dampness is composed of the traditional Chinese medicines and used for fuming and soaking the affected parts, so that circulation is improved, metabolism is removed, aggravated numbness is expelled, and the effects of dredging the channels, softening the swelling and gradually improving the joint function are achieved. The medicament is pure natural plant medicine liquid which is externally used and has the advantages of being low in preparation cost, convenient to use, good in treatment effect and free of toxic and side effects.
The medium-dose group was treated with medium-dose capecitabine: 1,000 mg/m2 orally twice daily (once in the morning and once in the evening; equivalent to a total daily dose of 2,000 mg/m2). Treatment was given for 2 weeks, followed by a 1 week of discontinuation, with each cycle lasting 3 weeks, and there were a total of 4 cycles. Administration: Swallow the tablet whole with water 30 min after breakfast and dinner every day.
As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome. Here, by analyzing whole-genome sequencing data in a non-gene-centric manner, we identify 881 duplication hotspots in 13 major cancer types, most of which do not contain protein-coding genes. We show that the hotspots are enriched with distal enhancer elements and are highly lineage-specific. We develop a HiChIP-based methodology that navigates enhancer-promoter contact maps to prioritize the target genes for the duplication hotspots harboring enhancer elements. The methodology identifies many novel enhancer duplication events activating oncogenes such as ESR1, FOXA1, GATA3, GATA6, TP63, and VEGFA, as well as potentially novel oncogenes such as GRHL2, IRF2BP2, and CREB3L1 In particular, we identify a duplication hotspot on Chromosome 10p15 harboring a cluster of enhancers, which skips over two genes, through a long-range chromatin interaction, to activate an oncogenic isoform of the NET1 gene to promote migration of gastric cancer cells. Focusing on tandem duplications, our study substantially extends the catalog of noncoding driver alterations in multiple cancer types, revealing attractive targets for functional characterization and therapeutic intervention.
To provide preventive agents against infectious diseases caused by fine droplets such as the novel coronavirus.SOLUTION: Provided is a preventive agent against infectious diseases. The agent comprises an effective amount of one or more selected from the group consisting of benzalkonium chloride and hypochlorous acid components and titanium-catalyzed water. The hypochlorous acid component exists as hypochlorous acid and/or sodium hypochlorite. The concentration of benzalkonium chloride is 0.01 to 0.2 w/v%, and the effective chlorine concentration of the hypochlorous acid component is 1 to 7500 ppm. Titanium-catalyzed water is produced as a result of forced flow contact of water with metallic titanium, and the concentration thereof is 0.001% v/v or more as a 1000-fold reference diluent. The preventive agent against infectious diseases has a pH of 5 to 10 and can be sprayed on nose, throat, hands/fingers, etc., and may also be imparted with a mosquito repellent effect.SELECTED DRAWING: Figure 3
The invention discloses a body fluid small molecule metabolic marker of Amphioxus bacteria, which is at least one of alanine, aspartic acid, aminobutyric acid and glutamine, preferably glutamine. The application of the body fluid micromolecule metabolic marker of the amphioxus infectious bacteria in detecting the amphioxus infectious bacteria and in preparing the medicines for treating the amphioxus infectious bacteria. Application of glutamine in regulating and controlling immune gene expression of branchiostoma. Use of glutamine to improve the immunity of a fish or mammal against bacterial infection. Experiments show that alanine, aspartic acid, aminobutyric acid and glutamine play an important role in the response of the amphioxus to bacterial infection, play an extremely important role in the innate immune response of the amphioxus, and can be used for research on the functions of a metabolome, detection and treatment of the amphioxus infected bacteria and the like. The invention has important reference value for researching the metabonomics related to the immune response of the amphioxus responding to bacterial infection.
In this study, children (6 months -18 years) undergoing all endoscopic procedures that includes an upper endoscopy including but not limited to Esophagogastroduodenoscopy (EGD/ upper endoscopy), EGD/ Colonoscopy, Endoscopic Retrograde Cholangiopancreatography (ERCP), Endoscopic ultrasound (EUS) e.t.c after appropriate consent, will be randomized 1:1 to either Air or CO2 gas for endoscopic insufflation. We will record demographics (name, age, sex, MRN, race/ethnicity), anthropometrics including weight, height/length, weight for length (WFL), WFL z score, BMI, BMI z score, indication/ reason for scope, other co-morbidities (other medical problems), personnel involved (faculty only, vs faculty + trainee), minute by minute end tidal CO2 levels, minute by minute minute ventilation levels, baseline blood pCO2, and blood pCO2 after each procedure. Pre and post procedure patient reported abdominal pain, bloating and flatulence. Pre and post procedure nurse assessed pain. Pre and post procedure vital signs. Patients will be randomized using a sealed envelope method by the endoscopy technician. Both patients and providers will be blinded to arm of enrollment.
Hypoxia exposure applied to professional athletes has attracted attention and scientific debate due to its effects on improving physiological response through cardiovascular and hematological mechanisms. Presently, hypoxic training programs are developed to improve exercise performance in athletes, a useful training method for athletes that may improve their performance in future sea-level competitions. 12 males were divided into the hypoxic (H) and control (C) groups. Group H was living and sleeping in hypoxic rooms (method live high-train low) for 8-14h/d (FiO2≈14%). The implementation of the project was intended to: 1) assess the dynamics of changes in the concentration of pro-inflammatory indicators and hematopoiesis in athletes to variable training loads and hypoxia, 2) explain the usefulness of hypoxic exposure in adaptation to physical exercise, 3) observe the length of the hypoxic cycle necessary to maintain the effect of high-altitude training. In the blood serum the level of basic biochemical indicators of fatigue related to muscle damage, inflammation, and energy deficit, i.e. total creatine kinase (CK) activity, C-reactive protein (hsCRP) concentration, nitric oxide (NO). Moreover, basic hematological indicators: morphology, reticulocytes, lipid profile, and ferritin. Also, angiogenesis regulators: vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR2 and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined using a body analyzer. Further investigations into hypoxia methods while considering individual capabilities are necessary for gaining deeper insights, into how hypoxia affects blood count and different blood variables among athletes.
VR is an attention-distracting technology via visual and auditory signals by a computer-generated virtual engulfing environment. This technology has already been used in a variety of medical conditions and previous studies have demonstrated the benefit of using it as an additional tool for pain relief and as a substitute to sedation in invasive procedure. In this study we examined the use of VR as a substitute for sedation in colonoscopy. In this randomized control study, 60 patients were sequentially enrolled in a 1:1 ratio to either standard sedated colonoscopy or VR-unsedated procedure. The primary outcome was the overall satisfaction of patients who underwent unsedated colonoscopy with VR headset compared with patients who underwent standard sedation colonoscopy. Pain during the procedure, PDR, colonoscopy duration, post colonoscopy adverse events, post colonoscopy recovery and time-to-return to daily functions and turnaround time at the endoscopy unit were secondary outcomes.
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) constitutes a distinctive cytogenetic entity associated with challenging outcomes, particularly in adult patients. Current upfront chemotherapy-tyrosine kinase inhibitor (TKI)-based therapies include first, second and third-generation TKIs that have revolutionized patient outcomes including molecular remission and overall survival. Chemotherapy-free regimens such as blinatumomab-dasatinib or blinatumomab-ponatinib offer exciting possibilities, yet challenges arise, particularly in preventing central nervous system relapse. Monitoring measurable residual disease is now a cornerstone particularly using next-generation sequencing (NGS)-Clonoseq for accurate assessment. Controversy regarding the ability to omit consolidation with allogeneic stem cell transplantation, specifically for patients achieving early molecular remission, is related to the excellent survival achieved with novel combinations in the upfront setting, however challenged by the lower disease control when transplant is utilized beyond first remission. Post-transplant maintenance introduces new dilemmas: the optimal TKI, dosing, and duration of therapy are open questions. Meanwhile, a myriad of new combinations and cellular therapies are used for relapsed Ph+ ALL, prompting us to unravel the optimal sequencing of these promising regimen. In this review, we delve into the breakthroughs and controversies in Ph+ ALL with ten commonly asked questions.
Carotid artery stenosis is one of the most common diagnoses treated by vascular specialists in the United States. The optimal management of carotid stenosis remains controversial, however, with notable variation surrounding diagnostic imaging modalities, longitudinal surveillance, medical therapies, and procedural interventions. Data from high-quality randomized controlled trials and observational studies form the foundation for current management paradigms and societal guidelines that inform clinical practice. Presently, a diagnosis of carotid disease is most often established with duplex ultrasound and supplemental cross-sectional imaging using computed tomography or magnetic resonance angiography as needed to provide additional anatomic information. All patients with documented occlusive disease should receive goal-directed medical therapy with antiplatelet agents and a lipid-reduction strategy, most commonly with a statin. Those with severe carotid stenosis and an acceptable life expectancy may be considered for carotid artery revascularization. The proceduralist should optimally consider a shared decision-making approach in which the tradeoffs of revascularization can be carefully considered with the patient to optimize informed therapeutic decision making. In current practice, three distinct procedure options exist to treat carotid artery stenosis, including carotid endarterectomy, transfemoral carotid artery stenting, and transcarotid artery revascularization. It should be noted that each procedure, although often used interchangeably in most clinical settings, carry technical nuances and outcome disparities. In this review, each of these topics are explored and various approaches are outlined surrounding the appropriate use of treatments for patients with asymptomatic carotid artery stenosis.