anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To provide an adjuvant containing abrine-a and applicable as an injection. CONSTITUTION:The objective adjuvant effective for the remedy and preventive of infectious diseases caused by microorganisms such as bacteria, viruses, etc. or cancer, is obtained by using abrine-a (a component of abrines separated from the seed of a leguminous plant, Abrus cantoniensis) as a component. The necessary minimum amount of abrine-a in the preparation is 0.1ng per a man or animal, and the maximum dose is 10mug. Since abrine-a is soluble in water, it can be administered for immunization as a mixture with an antigen or vaccine by the subcutaneous, intramuscular, peritoneal or intrathoracic infusion. Furthermore, since the activity of abrine-a is maintained stably in the presence of galactose, it is preferable to add 1-100mM of galactose to the preparation for improving the stability of the injection and for providing a diluent for freeze- drying.
CARD is being used for the 1st time as the vaccination delivery framework in participating pharmacies (2024-2025 fall/winter vaccinations only). CARD comprises of education, environment, engagement and evaluation components.
BACKGROUND AND OBJECTIVES: Several studies are currently exploring the anatomical origins of superior longitudinal fascicule (SLF) 2 and SLF-3, which are components of the frontoparietal network. This study aimed to achieve optimum visualization of the anatomical corridors of these fibers using Photoshop filters.
METHODS: Four postmortem brain hemispheres were dissected in accordance with the method proposed by Klingler and Ludwig. Dissections were performed under a surgical microscope (Carl Zeiss AG, Oberkochen, Germany) at 4× and 40× magnification. All dissections were documented at each stage using a professional digital camera (Canon EOS 600D) with a macro 100 mm lens (Canon), ring-flash attachment (Canon), and professional tripod (Manfrotto 808 C4). We aimed to improve the visual quality of the images by avoiding monotone using various the features and filters in Photoshop.
RESULTS: SLF-2 originates from the angular gyrus (Brodmann area [BA] 39) in the right hemisphere and has been observed to project fibers from BA7 and BA19 and toward BA8, 9, 10, and 46. Further, these fibers traverse from the depths of BA40, 2, 3, 1, and 6 as they progress. SLF-2 also projects fibers from the supramarginal gyrus in the left hemisphere. SLF-3 lies between the supramarginal gyrus and the inferior frontal lobe in both the right and left hemispheres.
CONCLUSIONS: The visual descriptions of the dissections were enriched after using Photoshop to avoid monotony. Increasing the visual quality with Photoshop features enable us to gain a better understanding of these pathways. Additionally, it facilitates the comprehension of the symptoms associated with pathology. We hope these results will further aid in reducing the occurrence of postoperative complications.
PROBLEM TO BE SOLVED: To make it possible to form an antimicrobial polymerizable cyanoacrylate film on the skin of mammals on the spot by compounding polymerizable cyanoacrylate ester and a composite of iodine molecules and biocompatible polymer at effective antimicrobial rations, thereby constituting the compsn. SOLUTION: This compsn. is prepd. by adding the iodine/biocompatible polymer composite to the cyanoacrylate ester compsn. As such cyanoacrylate ester, n-butyl-2-cyanoacrylate is preferably used. Polymers which are suitable for use as the cyanoacrylate ester compsn. on the skin of the mammals as the iodine composite; for example, polyvinyl pyrrolidone, etc., are used as the biocompatible polymer. The antimicrobial composite is formed by adding iodine thereto and is used. This compsn. is applied on the skin surface of the mammals. the antimicrobial polymer films is formed on the spot and the contamination with microorganisms is suppressed.
INTRODUCTION: The purpose of this study was to evaluate whether intramedullary nail contact with physeal scar improves construct mechanics when treating distal tibial shaft fractures.
METHODS: Axially unstable extra-articular distal tibia fractures were created in 30 fresh frozen cadaveric specimens (15 pairs, mean age 79 years). Specimens underwent intramedullary nailing to the level of the physeal scar locked with one or two interlocks or short of the physeal scar locked with two interlocks (reference group). Specimens were subjected to 800N of axial load for 25,000 cycles. Primary outcomes were stiffness before and after cyclic loading. Secondary outcomes were load to failure, load at 3 mm displacement, plastic deformation, and total deformation.
RESULTS: The physeal scar with one interlock cohort demonstrated 3.8% greater stiffness before cycling ( P = 0.75) and 1.7% greater stiffness after cycling ( P = 0.86) compared with the reference group. The physeal scar with two interlocks group exhibited 0.3% greater stiffness before cycling ( P = 0.98) and 8.4% greater stiffness after cycling ( P = 0.41) in relation to the reference group. No differences were identified regarding load to failure or load at 3 mm displacement. In specimens with two interlocks, those in contact with the physeal scar demonstrated significantly less plastic ( P = 0.02) and total ( P = 0.04) deformation.
CONCLUSIONS: Constructs ending at the physeal scar demonstrated stiffness and load to failure similar to those without physeal scar contact. Less plastic and total deformation was noted in two-interlock constructs with physeal scar contact, suggesting a possible protective effect provided by the physeal scar. These data argue that physeal scar contact may offer a small mechanical benefit in nailing distal tibia fractures, but clinical relevance remains unknown.
OBJECTIVE: Though initially protected from vessel dilation by estrogen, women may experience rapid abdominal aortic aneurysm (AAA) growth post-menopause. The rate of growth has been poorly defined in prior literature. Here, we describe aneurysm growth in a cohort of women found through an AAA screening program.
METHODS: Women with AAAs were retrospectively identified. Aortic imaging was reviewed, and measurements of maximum transverse and anterior-posterior diameters were completed. Growth was stratified by the type of aortic pathology (fusiform aneurysm, aortic ectasia, dissection with aneurysmal degeneration, saccular aneurysm) as well as size category (<3 cm, 3.0-3.9 cm, 4.0-4.9 cm, ≥5.0 cm) at diagnosis.
RESULTS: A cohort of 488 women was identified; 286 had multiple scans for review. The mean age of the entire cohort was 75 ± 9.9 years. Stratified by type of pathology, the mean age was 76 ± 8.9 years in patients with a fusiform AAA, 74 ± 9.8 years in ectasia, 65 ± 13.7 years in dissection, and 76 ± 5.6 years in saccular aneurysms. The maximum growth was highest in women with fusiform AAAs, followed by dissection, ectasia, and saccular pathology (9.7 mm, 7.0 mm, 3.0 mm, and 2.2 mm, respectively; P < .001). Comparing mean growth by year, the highest mean growth was in fusiform AAAs (3.6 mm vs 1.75 mm in dissection; P < .001). The Shapiro-Wilk test demonstrated that mean growth per year was non-normally distributed with a right skew. Stratified by aortic diameter at the time of diagnosis, mean growth/year increased with increasing size at diagnosis in fusiform AAAs and dissection (0.91 mm for <3 cm, 2.34 mm for 3.0-3.9 cm, 2.49 mm for 4.0-4.9 mm, and 6.16 mm for ≥5.0 cm in patients with fusiform AAAs vs 0.57 mm, 0.94 mm, 1.87 mm, and 2.66 mm, respectively, for patients with dissection). Smoking history was associated with a higher mean growth/year (2.6 mm vs 3.3 mm; P < .001). Conversely, patients with a family history of AAA had a lower mean growth/year (3.2 mm vs 1.5 mm; P < .001).
CONCLUSIONS: The rate of aneurysm growth in women varies based on pathology and aneurysm size, and women experience rapid aneurysm growth at sizes greater than 4.5 cm. Current screening guidelines are inadequate, and our results demonstrate that the rate of growth of fusiform aneurysms in women is faster than in men at a smaller size and may warrant more frequent surveillance than current Society for Vascular Surgery recommendations to prevent risk of increased morbidity.
1,254,935. Treatment of seborrheic dermatitis. R. G. VAN SANT. 5 Feb., 1969, No. 6145/69. Heading ASB. Hair and/or scalp treatment packs comprise N, N-diethyl-m-toluamide together with instructions requiring that it be applied to the hair and/or scalp for the control or treatment of seborrheic dermatitis. The N, N-diethyl-mtoluamide may be in the form of a 5 to 20% by volume solution in a carrier or vehicle, preferably aqueous isopropanol. Compositions for the treatment of seborrheic dermatitis comprise 7 or 12% by volume N, N-diethyl-mtoluamide dissolved or dispersed in a carrier or vehicle suitable for application to the scalp.
The present invention discloses a preparation process of glycyrrhiza flavonoid dispersible tablet and the application of the tablet as the active component in decreasing blood sugar. The activity test proves three dosage groups of the glycyrrhiza flavonoid dispersible tablet all play a significant role in decreasing blood sugar of hyperglycemic model mice caused by alloxan, adrenalin and dextrose; the role in decreasing blood sugar is equal to or more significant than similar sugar-reducing medicines in clinical use. At the same time, the 'three more and one less' symptom of the diabetic model mouse is obviously relieved and especially the drinking amount is obviously reduced. The mouse acute toxicity test proves that under the maximum dosage, the mouse has no toxic side effect and the weight growth is normal. The source of raw materials is wide, the main sugar-reducing component is taken from natural medicines and the sugar-reducing effect is obvious; therefore, the present invention is suitable for long-term use. The present invention with simple preparation technology and low production cost is suitable for large-scale industrial production.
Patients assigned to the CHRP-BB will receive a weekly HIV risk reduction and PrEP adherence group level intervention led by two facilitators trained and supervised by the PI, a licensed clinical psychologist. It is a substantially shortened version of the comprehensive Holistic Health Recovery Program (HHRP)-based interventions that have been identified as demonstrating evidence of effectiveness in two randomized clinical trials. The CHRP-BB, which includes four 50-minute groups (1 group per week), will contain only content that relates explicitly to drug- or sex-related HIV risk reduction and PrEP adherence. Participants in both conditions will receive routine clinical services (i.e., daily methadone and case management).
BACKGROUND: Early post-stroke seizures (EPSS) are associated with an increased risk of mortality and post-stroke epilepsy. This study aimed to identify potential risk factors for EPSS, focusing on blood parameters, such as the neutrophil-to-lymphocyte ratio (NLR), which is a biomarker for inflammation.
METHODS: Patients treated for ischemic stroke between 2017 and 2019 were retrospectively identified. 44 of them had a first epileptic seizure within 7 days after the stroke. They were matched 1:2 for age and sex with controls who had a stroke but no EPSS. Information on demographics, stroke characteristics, and blood parameters were collected on admission. Logistic regression was used to identify variables associated with EPSS and the area under the receiver operating characteristic curve (AUROC) to estimate their predictive accuracy.
RESULTS: The NLR value (p = 0.035), National Institutes of Health Stroke Scale (NIHSS) (p = 0.016) and cortical localization of stroke (p = 0.03) were significantly correlated with the occurrence of EPSS in univariate logistic regression. In multivariable logistic regression, after adjusting for age, sex, baseline NIHSS, and stroke localization, the NLR values [adjusted odds ratio 1.097, 95% confidence interval (CI): 1.005-1.197; p = 0.038] were independently associated with the occurrence of EPSS. The AUROC for NLR was 0.639 (95% CI: 0.517-0.761) with 2.98 as the best predictive cut-off value. There was a significant positive relationship between NLR and NIHSS, rS(87) = 0.383, p = <0.001.
CONCLUSION: Higher NLR values were associated with increased risk of EPSS. This biomarker appears useful to assess the risk of developing EPSS.
Patients will receive 1 to 3 preparation sessions (which will include psychoeducation and preparation exercises before EMDR), followed by up to 12 EMDR sessions, delivered over encrypted Zoom videoconferencing. EMDR is an evidence based trauma therapy. These EMDR sessions will focus on the experiences, urges or negative thoughts associated with their suicidal thoughts. The sessions will be 90 minutes in length and occur twice per week. This group will also have access to usual psychiatric care, which usually includes a family doctor or psychiatrist, mental health therapist and having access to Edmonton's community mental health programs.
Provided are health care potato chips. The invention relates to a kind of health care potato chips for preventing and treating hyperlipemia diseases. The health care potato chips are characterized in that the health care potato chips comprise the following raw materials: corydalis decumbens traditional Chinese medicine fluid extract dry power, honey and potatoes at a weight ratio of 10-20:1-2:100; The preparation of the corydalis decumbens traditional Chinese medicine fluid extract dry powder is as follows: fluid extract is prepared from corydalis decumbens and phyllostachys glauca roots at a weight ratio of 10:7-10, and the fluid extract is then subjected to freeze drying and crushed into dry powder. A new taste and health care effects of reducing blood fat of potato chips are additionally provided. The corydalis decumbens traditional Chinese medicine is pungent and warm in nature and is easy to harm yin blood, phyllostachys glauca roots are employed to overcome the shortage, thus the taste is mellow, fresh and sweet. The health care potato chips can relax muscles and activating blood, and have effects of reducing blood fat. The health care potato chips are suitable for auxiliary health care for preventing and treating hyperlipemia diseases.
All participants are advanced NSCLC without druggable gene mutation (EGFR, ALK, ROS-1, Met, Ret. BRAF, etc), who would receive platinum-based chemotherapy.
Stress urinary incontinence (SUI) is a common disease of female. The inconvenience caused by SUI affects the patients' quality of life and health seriously. To date, there has not specific therapy on SUI. Former research showed acupuncture may work for SUI. This multi-center randomized controlled clinical trial of acupuncture for simple female stress urinary incontinence is designed to confirm the efficacy and safety of EA. This project is conducted by Chinese researchers, supported by the Chinese Government. The research result is expected to provide high quality evidence of EA for simple female stress urinary incontinence.
Idiopathic CD4+ lymphocytopenia (ICL) is a disorder characterized by decreased numbers of circulating CD4+ T lymphocytes in the absence of known causes of CD4+ lymphocytopenia. ICL is defined as an absolute CD4+ T cell count of less than 300 cells/microL in a patient with no human immunodeficiency virus infection or known immunodeficiency syndrome. The causes and frequency of the disorder remain unknown. The condition is typically diagnosed when patients present with a serious infection. In this natural history protocol, we will evaluate patients with CD4+ T cell counts below 300 cells/microL. We propose to follow 300 ICL patients for a minimum of 4 and maximum of 20 years, with a particular focus on the association between ICL and autoimmune disease. In addition to the ICL patients, we will enroll blood relatives and household contacts to better understand pathogenesis and etiologies of the syndrome. We will collect blood and other tissues for immunologic, rheumatologic, and genetic testing in an effort to identify and understand the underlying defects that cause ICL and follow its course in a cohort of patients who will receive best standard therapy for opportunistic infections.
A prescription and a method for treating kidney meridian and lung meridian associated disease by the use of a traditional Chinese medicine. The medicinal prescription is as follows: 3g of Asarum Herb, 3g of anemarrhena, 3g of Meadowrue Root and Rhizome, 3g of Humulus scandens, 3g of radix scrophulariae, 1g of morning glory seeds, 2g of levisticum, 2g of Herba Siegesbeckiae, 3g of wrinkled giant hyssop, 3g of cucurbit, 3g of rhizoma drynariae, 3g of alkali halide, 2g of clove, 3g of combined spicebush, 1g of tarragon, 3g of pumex, 3g of polygala root, 3g of muscardine silkworm, 2g of borneol, 2g of american ginseng, 3g of polygonatum rhizome, 3g of gecko, 2g of Cordyceps sinensis, 2g of donkey-hide gelatin and 3g of asparagi radix. Selected acupoints are as follows: Rangu, Zhaohai, Fuliu, Zhubin, Dahe, Siman, Huangshu, Yindu, Shufu, Yuji, Taiyuan, Lieque, Xiabai, Tianfu and Yunmen. Auxiliary devices are as follows: a barrel for discharging foreign substances, a barrel for introducing medicaments, an auxiliary barrel, an ozone generator, a supersonic generator for discharging foreign substances and the like. Auxiliary articles are as follows: purified water, Asarum Herb and Chinese gall. The prescription provided by the invention can be used to treat the kidney meridian and large intestine meridian associated disease and can be applied in clinic.
PURPOSE:To provide excellent infrared ray screening effects and thereby improve effects such as impartment of refreshing feeling or makeup durability and makeup effects such as uniformity of transparency or adhesion by obtaining a cosmetic containing an amorphous nano-complex in which a TiC phase is dispersed in a TiN phase therein. CONSTITUTION:A cosmetic is composed of a complex having a coating layer on a complex composed of at least two layers of a metallic nitride and a metallic carbide. The complex has 0.01-40mum average particle diameter and is preferably a nano-complex. The nano-complex is composed of a fine disperse phase and a matrix phase in which the fine disperse phase is dispersed. TiN with TiC, Si3N4 with SiC, TiC with WC, etc., are preferred combinations. The nano-complex may have a white coating layer such as a metal, e.g. gold or silver or a metallic oxide, e.g. In2O3 or Nb2O5 on the surface and is especially improved in near infrared ray screening effects. The cosmetic can be applied to lipsticks, foundations, eye products, etc., as a form of the cosmetic.
The present invention is to provide a use of breast cancer anti-estrogen resistance 4 (BCAR4) exon 4 to be used as a gene marker for diagnosing lung cancer and a fusion gene including the same. The BCAR4 exon 4 is significantly expressed in a cancer tissue of a lung or breast cancer patient, in comparison with a normal tissue. In particular, the BCAR4 exon 4 is expressed as a sequence of a CD63-BCAR4 fusion gene where BCAR4 exon 4 and a portion of a CD63 gene are fused. Thus, the BCAR4 exon 4 can be used as a marker for a lung cancer gene. In addition, regulation of the expression of the fusion gene, in which BCAR4 exon 4 and the CD63 gene sequences are fused, can reduce the growth rate and migration ability of cancer cells. Therefore, a medicine capable of suppressing the expression of BCAR4 exon 4 and the fusion gene including the same can be used as an active ingredient of a pharmaceutical composition for lung cancer treatment or metastasis suppression.
No application will be made to the control group. However, these patients will be included in the exercise program they want after the 8-week treatment period is completed.
At this time, Meds-in-Hand is not currently utilized for approximately 40% of patients admitted to the pediatric ward at Boston Medical Center. Currently patients do not receive their discharge medications via the delivery service for a variety of reasons, however they continue to receive the usual care standard employed by most hospitals, where prescriptions are sent to their home pharmacy for pickup after discharge. This study does not change the actual medications patients receive, but how and when they get them. Rigorous study of the relationship between Meds-in-Hand and patient satisfaction and clinical outcomes has not been performed to date, so there is equipoise about the value of the intervention, however observational data in the population in question, namely children admitted for an asthma exacerbation, suggest that patients who receive Meds-in-Hand prior to discharge have a reduced likelihood of a return visit to the Emergency Department in 30 days. The study will focus on parent-patient dyads admitted with an asthma exacerbation where the child is aged 2-17 years, however parents will be the exclusive study subjects. Parents of the patients will be asked a baseline, in-hospital survey as well as participate in phone follow-up interviews to report on the patient experience and parent-reported child health outcomes at approximately 3 and 30 days after leaving the hospital. 60 total parents will be enrolled, 30 in each arm of the study. This pilot study will also obtain empiric estimates of key study parameters to inform future study design and begin to examine trends between the groups of patients who are randomized to the Meds-in-Hand intervention and those randomized to usual care.
Systems and methods for personalizing medicine utilizing the true state of the patient are provided. A number of medical records for a patient are subjected to predictive modeling for various conditions (known as patient ‘true state’). The patient personal information, previous care, and true state may be provided into a state machine in order to determine the resources needed for the patient. The medical resources may be any of laboratory services, diagnostics, therapies and medications. Using the true state information, and number of activities may be performed for the patient based upon the patient's needs. These activities include scheduling lab or diagnostic procedures in advance of an appointment, filling in documentation gaps, identifying items that require additional documentation using the true state, and tracking follow-up. It may also be beneficial to validate the true state.