anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cancer metastasis, the leading cause of cancer-related deaths, remains a complex challenge in medical science. Stephen Paget's "seed and soil theory" introduced the concept of organotropism, suggesting that metastatic success depends on specific organ microenvironments. Understanding organotropism not only offers potential for curbing metastasis but also novel treatment strategies. Microphysiological systems (MPS), especially organ-on-a-chip models, have emerged as transformative tools in this quest. These systems, blending microfluidics, biology, and engineering, grant precise control over cell interactions within organ-specific microenvironments. MPS enable real-time monitoring, morphological analysis, and protein quantification, enhancing our comprehension of cancer dynamics, including tumor migration, vascularization, and pre-metastatic niches. In this review, we explore innovative applications of MPS in investigating cancer metastasis, particularly focusing on organotropism. This interdisciplinary approach converges the field of science, engineering, and medicine, thereby illuminating a path toward groundbreaking discoveries in cancer research.
Pneumonia is a lung infection that is a common complication in people with cancer, because of a weak immune system. Fiberoptic bronchoscopy is a test that is commonly used to help doctors diagnose the type of lung infection and treat it appropriately. It involves passing a thin tube with a camera at the end inside the lungs, and taking some fluid samples which are sent for analysis. While this procedure is being performed, a small amount of oxygen is delivered into the nose (low flow nasal cannula). Occasionally during this procedure, the blood oxygen of the patient may drop (even if the patient is receiving oxygen, and especially if the patient has severe pneumonia), and the procedure may have to be interrupted or prematurely stopped. If the oxygen level drops significantly, an intervention such as increasing the oxygen flow, or in the worst-case scenario temporarily placing the patient on a breathing machine is required. An alternative device called 'Optiflow' can provide high flow oxygen through nasal cannula, and is comfortable for patients. Optiflow was approved by Health Canada in 2006, and is commonly used in hospitals in Ontario and around the world to support patients whose blood oxygen is low. If Optiflow is used during bronchoscopy, it may prevent the blood oxygen from dropping.
Formulations for oral care products that incorporate coconut oil for effectively removing bacteria from the mouth and methods for making these products are disclosed herein. A preferred mouth rinse contains alkaline water, coconut flavor oil extract, sodium lauryl sarcosinate, zinc chloride, 30% xylitol solution, glycerin, aloe barbadensis leaf juice, and optionally, sodium benzoate, de ionized water, and mint flavor extract. A preferred toothpaste contains alkaline water, coconut oil, hydrated sylica sident 9, hydrated silica sident 22s, glycerin, xylitol, Irish moss, sodium coco sulphate, aloe babadensis leaf juice, titanium dioxide, and flavor. The percentage of the coconut oil content in the preferred products is in the range of 20%-80%, but most preferably 40%-60%. Drawing t Holstic and Healthy Coconut Akcohot Free Mouth Rinse Alkaline Water 40,375 Pure Coconut Flavor Oil Etract 12.626 Alkaline Water 2178 Sodiurm -auryl Sarcosinate 0,22 Zinc Chlorid-1. 30% Xylito! Solution.0 Glycerin 1 Aloe Barbadensis L.eaf julce SodIurn Senat 09 De~ ionizedWae9. Natural Mint Flavor Extract 0.3
Efficient removal of fibrillar collagen is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we used mice to further define the mechanism for this collagenolytic process. We show that loss of collagen type-1 (CT1) and increased CT1-fragment levels in expanding SAT are associated with proliferation of resident M2-like macrophages that display increased CD206-mediated engagement in collagen endocytosis compared to chow-fed controls. Blockage of CD206 during acute high-fat diet-induced weight gain leads to SAT CT1-fragment accumulation associated with elevated inflammation and fibrosis markers. Moreover, these SAT macrophages' engagement in collagen endocytosis is diminished in obesity associated with elevated levels collagen fragments that are too short to assemble into triple helices. We show that such short fragments provoke M2-macrophage proliferation and fibroinflammatory changes in fibroblasts. In conclusion, our data delineate the importance of a macrophage-collagen fragment axis in physiological SAT expansion. Therapeutic targeting of this process may be a means to prevent pathological adipose tissue remodeling, which in turn may reduce the risk for obesity-related metabolic disorders.
Sham Reiki will be administered for 5 consecutive days even if the subject is transferred to the floor from the ICU. Thirty minutes before and after the daily sham Reiki, session, the bedside nurse will obtain a set of baseline vital signs (heart rate, respiratory rate, blood pressure; non-invasively) for safety monitoring data.
A method, computer program product, and system include a processor(s) obtains various data relevant to one or more infected individuals (e.g., location data and infection data. The processor(s) identifies relationships and physical proximity between people comprising the one or more infected individuals and additional individuals, based on the various data. The processor(s) generates, based on the various data, a geofence. The processor(s) utilizes the geofence, the relationships, the physical proximity, and the various data, to predict that a portion of the additional individuals are more likely than not to be infected with the infection. The processor(s) generates a scoring model to identify a source of the infection. The processor(s) applies the scoring model to a group consisting of the one or more individuals, the portion of the additional individuals, and the physical locations, to identify the source of the infection (i.e., a person or physical locations).
The present invention relates to a method for preparing kidney-benefiting fatigue-reducing soybean milk sheet with micron pilose antler, safflower, cactus and dodder powder. Various kinds of traditional soybean milk sheets are added with micron pilose antler powder, micron rhodiola root powder, micron bee pollen, micron cactus powder, micron dodder powder and xylitol which are crushed into ultrafine powder by high-tech air stream, all kinds of raw material are combined and processed, and the kidney-benefiting fatigue-reducing soybean milk sheet is obtained. The kidney-benefiting fatigue-reducing soybean milk sheet has the obvious efficiency for benefiting a kidney, strengthening yang, resisting fatigue, enhancing immunity, etc. Middle-age people and old people who have deficiency of the kidney and debility can obtain hundreds of kinds of nutrient substances, such as rich proteins, vitamins, minerals, active ferments, etc. Simultaneously, because the soybean milk sheet is added with the micron rhodiola root powder which is called as a good product for reducing fatigue in the east, health care functions of the soybean milk sheet, such as fatigue resistance, ageing resistance, cancer resistance, mutation resistance, oxygen deficit resistance, low temperature resistance, hypoglycemic activity, radiation resistance, etc., are intensified. Therefore, the soybean milk sheet prepared by the present invention is a good kidney-benefiting fatigue-reducing soybean milk sheet which is especially designed for middle-age people and old people who have deficiency of the kidney and debility all over the world, has Chinese characteristics and has the functions of health care and service life prolonging.
Subjects aged between 6 and 12 weeks at the time of first vaccination received by intramuscular injection a 3-dose vaccination course of Engerix-B® vaccine at days 14, 44 and 74 and a 3-dose of TETRActHib™ vaccine at days 0, 30 and 60. The Engerix-B® vaccine was administered in the left anterolateral thigh, and the TETRActHib™ vaccine in the right anterolateral thigh.
We describe a method for opening the blood-brain barrier (BBB) using ultrasound and preformed microbubbles. With this method, diagnostic or therapeutic agents may be administered to the brain. This method can open a focal region of the BBB and administer agents in a targeted fashion or the method can open large regions (or the entirety) of the brain for more global administration of agents. In one embodiment, the method can be used to administer contrast agents (e.g., agents that increase or decrease the magnetic resonance imaging signal) to the brain and thereby improve the quality or information content of imaging data. In another embodiment, a standard clinical diagnostic ultrasound scanner can be used to open specific regions of the BBB and administer diagnostic or therapeutic agents. Importantly, this invention can open the BBB in a non-destructive/non-invasive fashion, allowing the subject to be awake and suffer no detectable side effects.
<P>PROBLEM TO BE SOLVED: To provide a safe and lightly ingestible food and drink carrying out amelioration and prophylaxis of symptoms of pollinosis without adverse effects, etc.  <P>SOLUTION: The food and drink is composed of a pink shrimp, a soup stock-containing Miso and water. That is, about 200 ml of the pink shrimp Miso soup is continuously drunk in the morning, in the afternoon and at night. Thereby, the ingestion can lightly be carried out without the adverse effects, etc. The amelioration and prophylaxis of the pollinosis are carried out with the safe and easily drinkable shrimp Miso soup.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Patients receiving intercostal nerve cryoanalgesia. The cryoanalgesia technique will be performed by the surgeon before the closure of the minithoracotomy, at the level of the 3rd, 4th and 5th intercostal spaces on the right hemithorax.
We systematically reviewed observational and Mendelian randomization (MR) articles that evaluated the association between obesity and 17 gastrointestinal (GI) diseases to integrate causal and observational evidence. A total of 594 observational studies from 26 systematic reviews and meta-analyses and nine MR articles were included. For every 5 kg/m2 increase in body mass index (BMI), there was an increased risk of GI diseases ranging from 2% for rectal cancer (relative risk [RR]: 1.02, 95% confidence interval [CI]: 1.01 to 1.03) to 63% for gallbladder disease (RR: 1.63, 95% CI: 1.50 to 1.77). MR articles indicated that risks of developing GI diseases elevated with each 1 standard deviation increase in genetically predicted BMI, ranging from 11% for Crohn's disease to 189% for nonalcoholic fatty liver disease. Moreover, upper GI conditions were less susceptible, whereas hepatobiliary organs were more vulnerable to increased adiposity. Among the associations between obesity and the 17 GI conditions, causal relationships were inferred from only approximately half (10/17, 59%). This study reveals a substantial gap between observational and causal evidence, indicating that a combined approach is necessary to effectively inform public health policies and guide epidemiological research on obesity and GI diseases.
The invention relates to a children swelling-subsiding pain-relieving external paste, and belongs to an external traditional Chinese medicine prescription of the medical field. The invention aims at solving problems of poor swelling-subsiding and pain-relieving effect, irritation, itchy skin causing, and children scratching causing of traditional Chinese medicine external preparations. The paste provided by the invention adopts a technical scheme that the paste is composed of 12g of rhubarb, 12g of salvia miltiorrhiza, 10g of peach seed, 15g of safflower, 12g of myrrh, 15g of frankincense, 5g of dragon's blood, and 200g of honey. According to the invention, 12g of rhubarb, 12g of salvia miltiorrhiza, 10g of peach seed, 15g of safflower, 12g of myrrh, 15g of frankincense, and 5g of dragon's blood are crushed and are sieved by using a 120-mesh sieve; and the materials are well mixed with the 200g of honey, such that the paste is prepared. The paste is applied at an afflicted part of a child, such that good swelling-subsiding, pain-relieving, and itching-relieving effects are achieved, and scratching is not caused. The external paste is mainly used in local swelling subsiding, pain relieving, and itching relieving after an external injury of a child, and is used for preventing scratching.
Systems and methods are provided for improving skincare product formulations to address predicted skin trends. A biomarker analysis system is used to determine concentrations of various protein biomarkers of a user. A skin diagnosis computing device uses the protein biomarker concentrations to determine one or more skin trends, and determines one or more skincare product ingredients to address the skin trends. A skincare product is compounded that includes the one or more skincare product ingredients. In some embodiments, protein biomarker concentration information for a subject is obtained, and is used to determine one or more skin trends likely to be experienced by the subject. Skincare product recommendations are generated based on the protein biomarker concentration information. Feedback on the recommended skincare products may be received, and may be used to improve future recommendations for skincare products for the subject or for other subjects.
Liposomes have been used in technologies in biological, pharmaceutical, medical and nutritional applications because they can offer biocompatibility, biodegradability, reduced toxicity, and capacity for size and surface modifications. Traditionally, liposomes are prepared by multiple steps. However, multiple steps of preparation may cause a number of problems including low yield, high polydispersity, and poor morphology. Here, we synthesized liposomes containing magnetic iron oxide nanoparticle using one-pot, single step synthesis under ultra-sonication. We optimized the lipid compositions, sonication power, concentration of iron oxide nanoparticles, and antibody conjugation using Cu-free click chemistry. Furthermore, we incorporated doxorubicin inside magnetic liposomes for combined antibody targeting and magnetic guidance. Fluorescence imaging and quantification confirmed that antibody conjugated magnetic liposome showed high cell specific targeting that was enhanced by magnetic delivery.
BACKGROUND: The proposed trial is to examine the feasibility of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT)-guided cytoreduction plus apalutamide and androgen deprivation therapy (ADT) for newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) at oligometastatic state.
METHODS: CHAMPION (NCT05717582) is an open-label, single-arm, phase II trial, planning to enroll newly diagnosed mHSPC cases with oligometastases (≤ 10 distant metastatic sites in conventional imaging). Patients will receive 6 cycles of apalutamide plus ADT. Patients with oligometastatic disease at PSMA PET/CT after 3 treatment cycles will receive cytoreductive radical prostatectomy. PSMA PET/CT-guided metastasis-directed external radiation therapy will be determined by the investigators. Apalutamide plus ADT will be continued for 2 weeks postoperatively. The primary endpoint is the proportion of patients with undetectable prostate-specific antigen (PSA), no disease progression, and no symptom deterioration after 6 cycles of apalutamide plus ADT. Secondary endpoints include the percentage of patients with PSA ≤ 0.2 ng/mL and oligometastases by the end of 3 treatment cycles, PSA response rate, and safety. Fleming's two-stage group sequential design will be adopted in the study, where the null hypothesis is that the rate of patients with an undetectable PSA is ≤ 40% after 6 cycles of treatment, while the alternate hypothesis is an undetectable PSA of > 60%; with one-sided α = 0.05, power = 0.80, and an assumed dropout rate of 10%, the required number of patients for an effective analysis is 47. Enrolment in the study commenced in May 2023.
DISCUSSION: The multi-modal therapy based on treatment response may improve the prognosis of newly diagnosed mHSPC patients with oligometastases.
TRIAL REGISTRATION: The study is registered with Clinical Trials.Gov (NCT05717582). Registered on 8th February 2023.
PURPOSE: To enable to moisten the surface of skin, to absorb moisture to restore the natural flexibility to fit in dents of eyes or wrinkles, by including a flexible net to reinforce the activity in a thin film composed of hydrophilic gel. CONSTITUTION: A net is composed of woven fabric with thickness of 0.01-2mm and about 2-100 meshes/cm. In this case, especially, the ratio of the area of the net meshes to the whole area is to be 5-80%. It is preferable to compose gel of water soluble or water swelling polymer with dry extracts of 0.5-50wt.%. Polyvinyl alcohol, alkali metal salts of cross-linked carboxymethylcellulose, alkali metal salts of polyacrylate, etc., are used as the polymer. Thus, as the combination of net/gel is made flexible, a mask is made to quickly absorb moisture in a wet treated part and, consequently, the mask can be fit to a part of a face or a body.
The Coronavirus Disease-19 (COVID-19) pandemic is one of the biggest medical challenges in recent years. Whilst COVID-19 primarily affects the lungs, causing interstitial pneumonitis and severe acute respiratory distress syndrome, it also affects multiple organ systems, including the cardiovascular system(1-3). There are documented associations between severity of disease/mortality risk and advancing age, male sex and associated comorbid disease (hypertension, ischaemic heart disease, diabetes, obesity, COPD and cancer).(4,5) The most common complications include cardiac dysrhythmia(6,7), cardiac injury(8,9), myocarditis, heart failure, pulmonary embolism10 and disseminated intravascular coagulation(11).

The SARS-CoV-2 virus uses the ACE2 receptor (ACE2) to enter type 2 pneumocytes, macrophages, perivascular pericytes, and cardiomyocytes.(12) This may lead to myocardial dysfunction and damage, endothelial dysfunction, microvascular dysfunction, plaque instability, and myocardial infarction.(12) In addition, ACE2 is expressed in several other organs including cells lining the blood vessels (endothelial cells), ACE2 is a key player in the renin-angiotensin system (RAS) which is important in blood pressure regulation and is a target for some of the commonly used drugs used in the treatment of blood pressure. While ACE2 is essential for viral invasion, it is unclear if the use of the common antihypertensive drugs ACE inhibitors or angiotensin receptor blockers (ARBs) alter prognosis in those with COVID-19 infection.(12) Furthermore, there is evidence that the normally occurring bacteria in the gut (gut microbiome) directly influences the makeup of the human immune system and has been implicated in severity of COVID-19 as well as in the magnitude of the immune system response to SARS-CoV-2 infection(13).

This study (LOCHINVAR) is based on the pilot study "COVID-19 blood pressure endothelium interaction study" (OBELIX), funded by the Chief Scientific Office. Preliminary results showed that participants who had COVID-19 infection had an 8.6mmHg increase in their average 24hr systolic blood pressure, compared to those that did not have COVID-19 infection. The investigators will increase our recruitment of potential participants to meet our sample size of 150 participants (75 SARS-CoV-2 +ve cases and 75 SARS-CoV-2 -ve cases) built on OBELIX. This study will allow us to have a better understanding of the risks of developing high blood pressure or uncontrolled blood pressure following COVID-19 infection. This will allow doctors to be able to make a recommendation on the current/long term management of people with high blood pressure beyond the pandemic.
Ride-On Cars with Standing Postures (ROC-stand) The training guidelines and time are the same as the ROC-sit group, except for the posture of driving. The 70-minute standing session can be divided into two 30-minute sessions with 10-minute break, depending on the child's condition with the standing posture.
Epiretinal membranes are a disease of the retinal surface, that may affect visual acuity and cause metamorphopsia, occurring in approximately 20% of the population older than 60 years, as reported by Mitchell et al.. Using vitrectomy with membrane peeling, postoperative improvement of visual acuity and metamorphopsia may be achieved in a majority of patients. The surgical method has been used for some time, the first report on the surgical method of vitrectomy with membrane peeling was published by Machemer and dates back to 1978. Since the introduction of intraoperative optical coherence tomography (iOCT), intraoperative iatrogenically induced changes in retinal tissue can be detected and correlated with postoperative changes. Leisser et al. has been able to record "stretching" of the retinal tissue using this technique and has also been able to record the rarely occurring subfoveal and extrafoveal elevations of the ellipsoidal zone due to membrane peeling. These changes did not significantly affect postoperative visual acuity, according to Leisser et al., but did affect the development of postoperative microscotomas. Nevertheless, iOCT has the potential to document instrument tissue interactions such as dipping into retinal tissue with the forceps during grasping of the ERM at the starting point of membrane peeling. Diaz et al. demonstrated that there are postoperative changes in the "nerve fiber layer" after ILM peeling, but in that study, no recording of instrument/tissue interactions was performed using iOCT.

The aim of this study is to examine dipping into retinal tissue with the forceps during grasping of the epiretinal membrane at the starting point of peeling with iOCT.
The present invention is directed to a novel probiotic oronasopharyngeal formulation of spray-dried bacteria comprising saccharides as protectants, for administration in the oronasopharyngeal cavity. Resuscitation of the formulation of the present invention gives rise to rapid deployable and viable microorganisms with preserved antimicrobial activity, and was found particularly useful for nasopharyngeal administration to treat respiratory conditions in humans and animals. In a further aspect, the present invention is directed to the probiotic microorganisms used in the aforementioned formulation. As evident from the examples hereinafter, spray-dried compositions comprising  Lactobacillus  strains, in particular comprising  Lactobacillus rhamnosus  proved optimal in the oronasopharyngeal applications of the present invention. The application also provides the use of  Lactobacillus  strains as anti-pathogenic and antibiofilm agents, in particular against the common nasopharyngeal pathogens (whereby produced acids such as lactic acid are important antimicrobial factors). Also disclosed are the processes associated with the manufacture of the spray-dried probiotic formulations of the present invention, as well as the use thereof in treating or preventing of infections of the oronasopharyngeal cavity.