anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Combat sports, such as boxing and mixed martial arts [MMA], have the unique objective to finish a bout by way of knockout [KO] or technical knockout [TKO]. There are potentially both short- and long-term neurological injuries that can happen as a result of the repeated head trauma sustained in bouts, and thus it is imperative to identify the athletes that are at increased risk. Using an online database of professional boxing bouts [boxrec.com] over a 6-month period, KO/TKO rates were calculated across different states, weight classes, sex, and Fight Exposure Score [FES] categories. There was found to be a significant association between KO/TKO rates and weight class, sex, and FES category with heavyweights, males and FES 0 boxers having higher KO/TKO rates. KO/TKO rates were increased in winless boxers. KO/TKO rates across the states are documented in the study.
NEW MATERIAL:The compound of formula I [X is group of formula IV (Y is oxy, thio or imino; R is H, amino, 1-4C alkylamino, etc.), or group of formula V]and its salt. EXAMPLE:4-(4-Aminophenyl)-2-aminothiazole. USE:A cardiotonic agent. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II (Z is halogen) with the compound of formula III according to the reaction formula, in a proper solvent such as DMF, phenol, dioxane, etc. at 50-200 deg.C for 1-15hr. Copper or a copper compound may be used as the catalyst. The compound of formula I is e.g. the compound of formula VI, etc. The compound of formula I can be used as a cardiotonic for oral for parenteral administration.
This study consisted of 6 visits. Visit 1 was the Medical Screening Visit (skin prick test). Visit 2 and Visit 3 consisted of 2 consecutive EEC Visits (3 hours in the EEC followed by 7 hours in the Clinic, 10 hours total, each visit) followed by 7 days of wash-out. Visit 2 and Visit 3 occurred prior to dispense and the measures obtained during these visits were used as baseline. At Visit 4 patients were randomized and dispensed the assigned study medication for 7 days of at-home dosing. Visit 5 (Day 8 of treatment) and Visit 6 (Day 9 of treatment) consisted of 2 additional consecutive EEC Visits (3 hours in the EEC followed by 7 hours in the clinic, 10 hours total, each visit). During each EEC visit, patients were exposed to either ragweed or cat allergen, depending on their skin prick test results. Of the 180 participants enrolled, 170 received at least one dose of study treatment and were randomized to one of the three study treatments.
<P>PROBLEM TO BE SOLVED: To obtain a beautiful skin promoter that improves moisture and firmness of the skin and has preventing/ameliorating action on chapped skin, fine wrinkles, etc., by oral intake or skin application.  <P>SOLUTION: N-Acetyllactosamine and/or lactosamine is used as the active ingredient of the beautiful skin promoter. Further at least one kind selected from N-acetylglucosamine, glucosamine, chondroitin sulfate, hyaluronic acid, vitamin C, etc., may be used. The form of the beautiful skin promoter is preferably tablet, capsule, powder, granule or liquid. In the beautiful skin promoter, N-acetyllactosamine and/or lactosamine being the active ingredient is quickly absorbed and a part of it is used as a raw material for an acidic mucopolysaccharide such as hyaluronic acid, chondroitin sulfate, etc., by oral intake or skin application. Consequently, moisture and firmness of the skin are improved, a bleaching effect is exhibited and chapped skin, fine wrinkles, etc., are prevented/ameliorated.  <P>COPYRIGHT: (C)2007,JPO&INPIT
PROBLEM TO BE SOLVED: To easily obtain a granulated composition capable of sufficiently suppressing its offensive taste even without the need of enlarging its granular size and capable of easily flavoring itself as well by coating with gelatin a support with a physiologically active ingredient borne on a crosslinked type polymeric compound. SOLUTION: This granulated composition is obtained by coating a support where (A) a physiologically active ingredient having offensive taste (e.g. aspirin, valproic acid, ketoprofen, ibuprofen) is borne on (B) a crosslinked type polymeric compound (e.g. carmellose calcium, crosscarmellose sodium, polyvinylpyrrolidone crosslinked product, pref. being 1-100 μm in average granular size) with (C) gelatin (alkali-treated or acid-treated gelatin may be used, being pref. 50-350 bloom in jelly strength). It is preferable that the weight ratio A/B is (1:50) to (1:3), the component C accounts for 5-20 wt.% of the whole composition, and the weight ratio of the support to gelatin is (100:1) to (3:1).
Participants will exercise in simulated altitude start at a minimum of 2,000ft and will increase to no greater than 16,400ft with each visit. The increase will be in accordance to maintaining 40-60% of max work rate during room air work rate and based upon saturation of oxygen of between 70-80%.
Diester diterpenoid alkaloids (DDAs) are the main active ingredients of herbaceous perennial plants Aconitum. DDAs possess cardiotoxic and neurotoxic properties. Although most deaths caused by DDA poisoning are accidental, a few instances of suicide and homicide have been reported. Presented is a case of an acute aconitine (AC) poisoning following the ingestion of approximately 50 mL of homemade medicinal liquor. We described the clinical manifestations after poisoning and detailed postmortem changes, and detected the concentrations of AC and hypaconitine (HA) by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The decedent experienced a burning sensation in the gastrointestinal tract after poisoning, followed by flushing and paralysis of the face and limbs, and severe cardiac arrhythmia. An autopsy revealed cyanosis of the lips and nail beds; conjunctival hemorrhage in both eyes; pulmonary edema; tissue hemorrhage and congestion in multiple organs; and inflammatory cell infiltration in the stomach, duodenum, pancreas, and cardiac muscle. The concentrations of AC and HA were as follows: cardiac blood, 38.4 ng/mL and 7.1 ng/mL; pericardial fluid, 7.3 ng/mL and 41 ng/mL; urine, 28.1 ng/mL and 574 ng/mL; bile, 38.5 ng/mL and 108 ng/mL; gastric contents, 0.06 mg and 0.56 mg; liver tissue, 10.7 ng/g and 109.6 ng/g; and medicinal liquor, 0.568 mg/mL and 0.664 mg/mL, respectively. The clinical manifestations, anatomy findings, and quantitative data on the concentrations of AC and HA in body fluids and tissues will aid forensic investigations of deaths caused by acute AC poisoning.
In this group, all subjects will have the Natrox™ ODS will be applied to the ulcer and attached to the active Natrox™ Oxygen Generator using the tubing provided or regular dressing will be used. Dressings according to the standard practice guidelines will be used. Patients in this group will continue to receive treatment as described by the diabetic foot ulcer standard of care. The ulcer will be photographed at biweekly intervals for a period of 8 weeks to analyze ulcer surface area using a standardized digital imaging software.
Objective: To explore the value of predicting shunt-dependent hydrocephalus (SDHC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) based on whole brain CT perfusion(CTP) and clinical data within 24 hours at admission. Methods: The clinical and imaging data of aSAH patients who received interventional embolization in our hospital were retrospectively collected from March 2018 to August 2022. All patients underwent one-stop whole brain CT examination within 24 hours after symptom onset, and the qualitative and quantitative CTP parameters were obtained after post-processing. Follow-up was conducted once every 2 months by consulting electronic medical records or by telephone for 6 months. According to whether SDHC occurred or not, the patients were divided into SDHC group and non-SDHC group. The differences between the two groups were compared. Logistic regression model was used to analyze and determine the predictive factors of SDHC, and the SDHC predictive model was established. The effectiveness of the predictive model was evaluated by drawing the receiver operating characteristic (ROC) curve of the subjects. Results: A total of 414 patients were included, including 132 males and 282 females, aged (59±11) years. 17.6%(73/414) patients had SDHC. There were significant differences in the occurrence of acute hydrocephalus, the World Neurosurgical League Scale (WFNS), the Hunt-Hess scale, the modified Fisher score (mFS), and the qualitative and quantitative parameters of CTP between the two groups (both P<0.001). Multivariate logistic regression analysis showed that acute hydrocephalus (OR=8.621, 95%CI: 4.237-17.542),old age (OR=1.107, 95%CI: 1.068-1.148), high mFS and high Hunt-Hess classification (OR=3.740, 95%CI: 1.352-10.342) were the risk factors of SDHC in aSAH patients, and high mean cerebral blood flow (mCBF) (OR=0.931, 95%CI: 0.885-0.980) was a protective factor of SDHC.The area under ROC curve (AUC) of the prediction model constructed by these five variables was 0.923(95%CI: 0.89-0.95), with 84.5% sensitivity and 87.7% specificity. Conclusion: The mCBF and acute hydrocephalus, age, mFS and Hunt-Hess classification within 24 hours at admission can be used to predict SDHC for aSAH patients.
Anorexia nervosa (AN) is a mental illness with high rates of mortality and relapse, and no approved pharmacotherapy. Using the activity-based anorexia (ABA) model of AN, we previously showed that a single sub-anesthetic intraperitoneal injection of ketamine (30 mg/kg-KET, but not 3 mg/kg-KET), has an immediate and long-lasting effect of reducing anorexia-like behavior among adolescent female mice. We also showed previously that excitatory outflow from medial prefrontal cortex (mPFC) engages hunger-evoked hyperactivity, leading to the ABA condition of severe weight loss. Ketamine is known to target GluN2B-containing NMDARs (NR2B). Might synaptic plasticity involving NR2B in mPFC contribute to ketamine's ameliorative effects? We addressed this question through electron microscopic immunocytochemical quantification of GluN2B at excitatory synapses of pyramidal neurons (PN) and GABAergic interneurons (IN) in mPFC layer 1 of animals that underwent recovery from a second ABA induction (ABA2), 22 days after ketamine injection during the first ABA induction. The 30 mg/kg-KET evoked synaptic plasticity that differed for PN and IN, with changes revolving the cytoplasmic reserve pool of NR2B more than the postsynaptic membrane pool. Those individuals that suppressed hunger-evoked wheel running the most and increased food consumption during recovery from ABA2 the most showed the greatest increase of NR2B at PN and IN excitatory synapses. We hypothesize that 30 mg/kg-KET promotes long-lasting changes in the reserve cytoplasmic pool of NR2B that enables activity-dependent rapid strengthening of mPFC circuits underlying the more adaptive behavior of suppressed running and enhanced food consumption, in turn supporting better weight restoration.
Systems and methods for monitoring medical perioperative time periods by surgical and non-surgical procedure steps. Particular embodiments relate to capturing and accumulating medical intraoperative procedure step durations. A method for valuing a surgery timeline may be based on surgeon(s), surgical team, CPT codes, patient comorbidities and other factors. The method may receive historical metrics from prior perioperative steps and intakes the surgeon's duration estimate or the organization administrative staffs duration estimate or both. The method displays the surgery timeline by applying the historical prior surgery metrics with input from the facility user.The facility provides transparency into how all the perioperative step's times are accounted for within the period of time extending from when the patient enters the organization's facility (e.g. hospital, clinic, doctor's office, and the like) for surgical procedure until the time the patient is discharged.These various combinations are desirable to provide information to the surgeon, surgical team and organization's administrative staff to improve case efficiency, patient care and user satisfaction.
This editorial investigates chronic traumatic encephalopathy (CTE) as a course of Alzheimer's disease (AD). CTE is a debilitating neurodegenerative disease that is the result of repeated mild traumatic brain injury (TBI). Many epidemiological studies show that experiencing a TBI in early or middle life is associated with an increased risk of dementia later in life. Chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD) present a series of similar neuropathological features that were investigated in this work like recombinant tau into filaments or the accumulation and aggregation of Aβ protein. However, these two conditions differ from each other in brain-blood barrier damage. The purpose of this review was to evaluate information about CTE and AD from various articles, focusing especially on new therapeutic possibilities for the improvement in cognitive skills.
PROBLEM TO BE SOLVED: To provide an image processor capable of efficiently and easily managing even at vast amount of image information. SOLUTION: An input means 201 inputs subject identification information for identifying a subject. A managing means 116 manages information on the subject. Acquiring means 202 and 203 acquire from the managing means 116 information corresponding to the subject identification information inputted by the input means 201. A photographing means 204 photographs the subject on the basis of the information acquired by the acquiring means and obtains the image information of that subject. A preserving means 205 preserves the image information which is obtained by applying a prescribed image processing to the image information provided by the photographing means 204 together with the information acquired by the acquiring means.
Ibritumomab tiuxetan binds specifically to the CD20 antigen (human B-lymphocyte-restricted differentiation antigen, Bp35). The apparent affinity (KD) of ibritumomab tiuxetan for the CD20 antigen ranges between approximately 14 to 18 nM. The CD20 antigen is expressed on pre-B and mature B lymphocytes and on > 90% of B-cell non-Hodgkin’s lymphomas (NHL). The CD20 antigen is not shed from the cell surface and does not internalize upon antibody binding.

The chelate tiuxetan, which tightly binds Y-90, is covalently linked to ibritumomab. The beta emission from Y-90 induces cellular damage by the formation of free radicals in the target and neighboring cells.

Ibritumomab tiuxetan binding was observed in vitro on lymphoid cells of the bone marrow, lymph node, thymus, red and white pulp of the spleen, and lymphoid follicles of the tonsil, as well as lymphoid nodules of other organs such as the large and small intestines.
BACKGROUND: Postoperative shoulder-tip pain (STP) is a common complication following laparoscopic cholecystectomy (LC). The study seeks to determine whether acupressure can be used as an alternative to medication for pain relief, as medications often come with side effects. This study aims to evaluate the effect of acupressure on pain levels and physiological indicators in patients undergoing LC.
MATERIALS AND METHODS: This double-blind, randomized clinical trial was conducted on 81 patients who underwent LC at Al-Zahra Hospital of Isfahan University of Medical Sciences, Isfahan, Iran, in 2022. The patients were divided into two groups: the intervention group, which received acupressure (42 participants), and the control group (39 participants). The selected pressure points were LI11, LI4, SJ5, HT7, P6, and K1. Demographic and clinical data were collected, and the pain level was evaluated using the visual analogue score (VAS). The data was analyzed using SPSS version 16 software with a significance level of p < 0.05.
RESULTS: The intervention and control groups were homogeneous in terms of age, gender, duration of surgery, and pethidine consumption (p > 0.05). The average VAS significantly decreased in both the intervention and control groups (p < 0.001). The intervention group had a significantly higher reduced score compared to the control group, 30 min and 72 h after applying acupressure (p < 0.001). Significant differences were observed between the two groups in terms of changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and breath rate (BR) (p < 0.05).
CONCLUSIONS: acupressure can effectively improve STP and physiological indicators in patients undergoing LC.
TRIAL REGISTRATION NO: IRCT20150715023216N14 (Registration date: 2023-01-22, https://irct.behdasht.gov.ir/user/trial/68111/view).
A rat ganglioside GM 1 -specific α1→2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM 1 -specific α1→2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM 1 -specific α1→2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM 1 -specific α1→2fucosyltransferase and derivatives and analogs thereof (e.g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM 1 -specific α1→2fucosyltransferase (e.g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM 1 -specific α1→2fucosyltransferase in the production of fucosyl-saccharide compositions are described. Applications of these compositions, e.g. as additives for human nutritive compositions or immunotherapeutics for cancer, are disclosed.
PURPOSE: A composition containing Sophora flavescens extract or compound isolated therefrom is provided to suppress neuraminidase and to prevent and treat influenza virus infection. CONSTITUTION: A pharmaceutical composition for preventing and treating influenza virus infectious diseases contains Sophora flavescens extract as an active ingredient. The Sophora flavescens extract is isolatd using water, alcohol of C1-C4, or mixture solvent thereof. The pharmaceutical composition also contains fraction from the Sophora flavescens extract as an active ingredient. The fraction is fractioned by hexane, chloroform, and ethyl acetate. The pharmaceutical composition contains pterocarpan compound of chemical formula 1 or its pharmaceutically acceptable salt as an active ingredient. The pterocarpan compound is isolated from Sophora flavescens extract or fraction.
FIELD: biotechnology. SUBSTANCE: invention relates to method of preparing nutrient media used for bifidobacterium culturing and can be used in microbiological and food industry. Nutrient medium has a base, L-cysteine hydrochloride, D -(-)- -lactose, milk protein hydrolyzate, yeast autolyzate and sodium chloride. Skimmed milk pancreatic hydrolyzate is used as milk proteins hydrolyzate; yeast enzymatic autolyzate is used as yeast autolyzate; skimmed milk is used as a base normalized by dry residue in total content of amine nitrogen in nutrient medium 260-300 mg% and in the following quantitative ratio of its components, wt.-%: skimmed milk pancreatic hydrolyzate, 5.0-7.0; L-cysteine hydrochloride, 0.001-0.003; D-(-)-lactose, 0.03-0.09; sodium chloride, 0.01-0.05; yeast enzymatic autolyzate, 1.0-2.0; skimmed milk (base) normalized by dry residue, the balance up to 100%. Autolyzate with index of amine nitrogen 350-400 mg% is used as yeast enzymatic autolyzate. Skimmed milk is normalized by dry residue to value 13.0-14% and amount of added lactose is decreased by 1.5-2 times as compared with analogue. Method involves additional addition of soybean isolate in the amount 0.2-0.3% by mass to nutrient medium. Sodium citrate is added additionally to nutrient medium in the amount 0.1-0.2% by mass for activation of soybean isolate. EFFECT: increased storage period of bifidum-containing preparation by using proposed nutrient medium. 5 cl, 2 tbl
Electronic cigarette (e-cigarette) use is increasing in Europe and the USA. While mounting evidence exists regarding an array of associated adverse health effects, to date limited evidence exists regarding the health effects of e-cigarette use on cardiovascular (CV) disease (CVD). The present review summarizes the effects of e-cigarette use on CV health. A search strategy of in vivo experimental, observational studies (including population-based cohort studies), and interventional studies was conducted in PubMed, MEDLINE, and Web of Science (April 1, 2009-April 1, 2022). The main findings revealed that the influence of e-cigarette on health are attributed mainly to the individual and interactive effects of flavors and additives used in e-cigarette fluids, along with the extended heating. The above collectively stimulate prolonged sympathoexcitatory CV autonomic effects, such as increased heart rate and diastolic blood pressure (BP), as well as decreased oxygen saturation. Hence, e-cigarette users are at increased risk of developing atherosclerosis, hypertension, arrhythmia, myocardial infarction, and heart failure. Such risks are anticipated to increase, especially among the young who are increasingly adopting e-cigarette use particularly with flavored additives. Further investigations are urgently needed to evaluate the long-term effects of e-cigarette use, particularly among susceptible population groups such as youth.
IMPORTANCE AND OBJECTIVE: Postmenopausal endometriosis is a complex condition that challenges the conventional belief that endometriosis resolves with menopause. Despite the cessation of menstruation, a subset of women continues to experience or develop endometriosis-related symptoms during the postmenopausal period. Thus, this review aimed to shed light on postmenopausal endometriosis, exploring its clinical features, diagnostic considerations, management approaches, and the potential impact on women's health.
METHODS: PubMed/Medline, Scopus, and Web of Science databases were used for the research, with only articles in English language, using the following terms: "postmenopausal endometriosis," "menopause," "management," "treatment," and "quality of life," from inception to 2023.
DISCUSSION AND CONCLUSION: The clinical features of postmenopausal endometriosis include persistent or recurrent pelvic pain, dyspareunia, bowel, or urinary symptoms and, occasionally, abnormal vaginal bleeding. The absence of menstrual cycles presents a diagnostic challenge, as the traditional diagnostic criteria for endometriosis rely on menstrual patterns. Visual cues may be less evident, and the symptoms often overlap with other gynecological conditions, necessitating a thorough evaluation to differentiate postmenopausal endometriosis from other potential causes. Management approaches for postmenopausal endometriosis encompass surgical intervention, hormonal therapies, pain management, and individualized care. Postmenopausal endometriosis significantly impacts the quality of life, sexual health, and long-term well-being of women. Understanding the clinical features, diagnostic challenges, and management approaches of postmenopausal endometriosis is crucial for healthcare professionals to provide effective care and to improve the quality of life of women affected by this condition.
The invention provides a magnesium manganese alloy suitable for use in the production of a pellet 10 for administration to a ruminant by dposition in its rumeno-reticular sac. A typical pellet 10 comprises a magnesium alloy tube 12 enclosing a degradable core formed of plurality of tablets 14, 16. The magnesium alloy used in the construction comprises at least 90% by weight of magnesium, uyp to 1% zinc and up to 2% of manganese. Preferably the alloy may further include aluminium, silicon or zirconium along with iron and beryllium. When deposited in an animal's rumen the alloy reacts with the rumen juices to form an anodic film over the exposed surface of the tube 12. This prevents corrosion or dissolution of the tube 12 except at its exposed ends where galvanic corrosion by coupling with the electrically conductive core 14, 16 is provided. The normal requirement of a non-degradable exterior coating e.g. resin for the tube exterior is obviated.