anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Fluid expansion is the cornerstone of acute circulatory failure treatment in children Although this therapy drastically reduced mortality, several studies in recent years have highlighted the adverse effects of excessive fluid expansion (leading to fluid overload). Currently, the search for indicators to predict fluid responsiveness is a major issue in intensive care. These indicators are based on Franck-Starling's law: if small changes in preload lead to an increase in cardiac output, then fluid responsiveness can be expected. However, in children, the only validated indicator (respiratory variability of peak aortic velocity) can only be used in the absence of any spontaneous respiratory movement, a rare situation in practice. Recently, two pediatric studies investigated a simple clinical test: hepatic or abdominal compression. This clinical maneuver, by increasing venous return via mobilization of the hepato-splanchnic reserve, induces a transient and reversible preload increase. The evaluation of the hemodynamic effects of this "endogenous fluid expansion" allowed, according to the authors, to accurately predict fluid responsiveness. However, several factors reduce the applicability of these results: the small number of studies on this subject, the smaller volume of fluid used than in clinical practice, and the population studied, composed almost exclusively of children in postoperative of cardiac surgery.

In this study, the investigators will evaluate the diagnostic accuracy of abdominal compression for the diagnosis of fluid responsiveness in children with acute circulatory failure, hospitalized in pediatric intensive care unit (PICU) for a medical or a non-cardiac surgical condition, for whom a fluid expansion was prescribed by the physician in charge. The index test will be the stroke volume variation following a standardized abdominal compression (before fluid expansion). The gold standard test will be the variation of cardiac output between baseline and after fluid expansion, a variation \> 15% defining fluid responsiveness.

In this non interventional study of diagnostic accuracy, patients will undergo an extra echocardiographic assessment, but no supplemental blood test or invasive parameters will be collected. Simple clinical parameters will be collected within 4 hours after the fluid expansion. Patients will be follow-up until PICU discharge.
PURPOSE:To obtain a treating agent for cataract containing a 15-keto- prostaglandin compound as an active ingredient. CONSTITUTION:A treating agent for cataract is obtained by including a 15 keto-prostaglandin compound, e.g. 2-decarboxy-2-(2-carboxyethyl)-15-keto- prostaglandin as an active ingredient and preparing a formulation in the form of eye drops, an oral agent, an injection, a rectal administration agent, etc. In the case of local administration, the dose is 0.01-100mug/eye or in 2-4 divided portions per day. In the case of systemic administration in the form of a sustained form, the dose is 0.001-500mg/kg. The aforementioned agent is especially useful for preventing cataract and effective against senile cataract, traumatic cataract, nutritional cataract, diabetic cataract, cataract caused by chemical poisoning and cataract due to radiation.
In the TAU condition therapists provide treatment consistent with their orientation and clinical judgment. Previous research suggests that TAU will include supportive therapy, relaxation, and cognitive restructuring. The format of treatment will be 6 to 12, 50-minute, face-to-face therapy sessions in the therapist's office, with flexibility to leave the office (e.g., for exposure). Therapists can communicate with patients between sessions (e.g., phone calls), as long as this medium is not the primary mode of treatment.
This comparison group provides attention, social interaction, and healthy lifestyle classes. There will be 4, 1-hour face-to-face group meetings per year featuring community health professionals, quarterly newsletters, and quarterly text messages.
1,179,938. Medicinal tablets. MERCK & CO. Inc. 20 Nov., 1967 [23 Nov., 1966], No. 52706/67. Heading A5B. A sustained release tablet, which comprises a core composed of medicament dispersed in a wax or wax-like material and surrounded by a coating (which may also contain a medicament) which preserves its shape at the temperature at which the wax melts, is made by forming the core by compression of a mixture of wax and medicament, applying the coating by conventional methods, heating the tablet to ensure melting of the wax and cooling to room temperature. Suitable wax materials are hardened animal, vegetable and mineral oils, higher fatty alcohols and acids, beeswax, glycerol monostearate and polyethylene oxide. Suitable coating materials are methyl- and ethyl-cellulose, cellulose acetate, cellulose acetate phthalate and hydroxypropyl cellulose. Examples relate to tablets containing KCl, amitriptylene and chlorothiazide. An additional outer coating, e.g. of sugar, may be applied to the tablets.
Amblyopia affects 3% of the children and is caused by strabismus, anisometropia or both. The standard treatment is glasses and patching therapy. From North-America, behavioural training, i.e. dichoptic training, perceptual learning and video gaming, has become increasingly popular. The rationale behind these games is by using dichoptic stimulation, with the contrast of the stimuli presented to the good eye reduced to match the appearance of the same stimuli when shown to the amblyopic eye, suppression can be alleviated. The many studies now conducted, demonstrate improvement in visual acuity with the games, the effect however is limited, but the rate of improvement is higher. In these studies, prescribed patching-time was compared to realised game-time. We have demonstrated in multiple studies that electronically measured compliance is low: on average only 50%.

In this study we aim to compare the effect of patching therapy, using the ODM to objectively measure compliance, with the effect of a novel dichoptic action video game in children as well as in adults. In addition, the adult participants will undergo fMRI scans to document any changes in the visual cortex before and after either therapy.
Pelvic radiation therapy plays a key role in the treatment of common genitourinary (GU), gynecological (Gyn), and gastrointestinal (GI) malignancies of the pelvis. Prior to starting a course of radiation therapy, patients undergo a CT simulation that allows for computer-based optimization of radiation dose delivery to target while simultaneously minimizing dose to surrounding normal tissues, such as the bladder and rectum. Commonly, physicians instruct patients undergoing pelvic radiation therapy to present with a reproducibly full bladder for the simulation and for each subsequent treatment session with the hope that increased distance between normal tissues (anterior bladder wall and bowel) and treatment target will limit toxicity. However, treating with a full bladder can result in wide variations in bladder volume. Often patients are unable to reproduce the bladder distention achieved at simulation, especially as typical urinary symptoms related to radiation develop during treatment. As the initial CT simulation is used to calculate dose distribution, bladder volume changes can affect radiation dose distribution to the bladder itself as well as adjacent pelvic organs. Given the challenges and uncertainties of treating with a full bladder, there has been increasing interest in bladder empty protocols. Retrospective, non-randomized, single-institution studies demonstrate that bladder empty protocols reduced absolute variation in bladder volume during treatment, had minimal impact on treatment related toxicity, and had non-inferior biochemical progression free survival, GI toxicities, and GU toxicities. However, prospective data is very limited. The present study plans to fill this knowledge gap by randomizing study participants to empty and full bladder protocols for simulation and radiation therapy.
There will be a total of 14 visits in the study: will complete a screening visit, an initial visit, 10 session visits with active tDCS(transcranial direct current stimulation) andcognitive remediation therapy, and follow--up visits immediately (within 5 days), 1 and 3 months after the last intervention. Subjects will be informed of their group assignment at the end of the study.
BACKGROUND: Partial or complete thymectomy is routinely performed in paediatric open-heart surgeries when treating congenital heart defects. Whether or not thymectomised children require systematic immunological monitoring later in life is unknown. The objective of this study was to investigate the effects of preoperatively and postoperatively used antibiotics, hospitalisation and surgical complications on self-reported immunological vulnerability in paediatric patients with early thymectomy to better recognise the patients who could benefit from immunological follow-up in the future.
METHODS: We conducted a retrospective cohort study, including 98 children and adolescents aged 1-15 years, who had undergone an open-heart surgery and thymectomy in infancy and who had previously answered a survey regarding different immune-mediated symptoms and diagnoses. We performed a comprehensive chart review of preoperative and postoperative factors from 1 year preceding and 1 year following the open-heart surgery and compared the participants who had self-reported symptoms of immunological vulnerability to those who had not.
RESULTS: The median age at primary open-heart surgery and thymectomy was 19.5 days in the overall study population (60% men, n=56) and thymectomies mainly partial (80%, n=78). Broad-spectrum antibiotics were more frequently used preoperatively in participants with self-reported immunological vulnerability (OR=3.05; 95% CI 1.01 to 9.23). This group also had greater overall use of antibiotics postoperatively (OR=3.21; 95% CI 1.33 to 7.76). These findings were more pronounced in the subgroup of neonatally operated children. There was no statistically significant difference in the duration of intensive care unit stay, hospitalisation time, prevalence of severe infections, surgical complications or glucocorticoid use between the main study groups.
CONCLUSION: Antimicrobial agents were more frequently used both preoperatively and postoperatively in thymectomised children with self-reported immunological vulnerability after thymectomy. Substantial use of antimicrobial agents early in life should be considered a potential risk factor for increased immunological vulnerability when evaluating the significance of immune-mediated symptom occurrence in thymectomised paediatric patients.
Compositions comprising outer membrane protein "E", and peptides and oligope ptides thereof, of Moraxella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide, or oligope ptide are disclosed, as well as recombinant vectors cont aining these sequences. Protein, peptide, or oligopeptide can be produced from host  cell systems containing these recombinant vectors. Pept ides and oligopeptides can also be chemically synthesized. Disclosed are the uses  of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleo tide sequences are useful for constructing vectors for u se as vaccines, for insertions into attenuated bacteria in constructing a recom binant bacterial vaccume and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucle otide sequences related to the gene encoding E as primer s and or probes in molecular diagnostic assays for the detection of M. catarrh alis.
PURPOSE: Rheumatoid Arthritis (RA) has a point prevalence of around 20 million people worldwide. Patients with RA often believe that food intake affects disease activity, and that intake of red meat aggravate symptoms. The main objective of the Postprandial Inflammation in Rheumatoid Arthritis (PIRA) trial was to assess whether postprandial inflammation and serum lipid profile are affected differently by a meal including red meat, fatty fish, or a soy protein (vegan) meal.
METHODS: Using a randomized controlled crossover design, 25 patients were assigned to eat isocaloric hamburger meals consisting of red meat (60% beef, 40% pork), fatty fish (salmon), or soy protein for breakfast. Blood samples were taken before meals and at intervals up to 5 h postprandial. The analysis included the inflammation marker interleukin 6 (IL-6) and serum lipids.
RESULTS: No significant differences in postprandial IL-6 or triglyceride concentrations were found between meals. However, the area under the curve of very low density lipoprotein (VLDL) particle counts, as well as VLDL-4-bound cholesterol, triglycerides, and phospholipids, was higher after the fatty fish compared to both red meat and soy protein.
CONCLUSION: Postprandial inflammation assessed by IL-6 did not indicate any acute negative effects of red meat intake compared to fatty fish- or soy protein in patients with RA. The fatty fish meal resulted in a higher number of VLDL-particles and more lipids in the form of small VLDL particles compared to the other protein sources.
In the experimental group, 44 children will be provided with SDF application, after gross debris removal to allow better contact of SDF. The entire dentition will be treated with sodium chloride fluoride varnish to prevent caries.
1308565 Self-heating shaving creams GILLETTE CO 18 June 1970 [25 June 1969] 29619/70 Heading C5D [Also in Division A5] A self-heating pharmaceutical or cosmetic composition comprises a vehicle and a first and a second heat-generating component, maintained separately from one another but which when in contact with one another effect an exothermic reaction; at least one of said components being encapsulated in a plurality of frangible capsules which are dispersed in said vehicle, the encapsulating material for said capsules being both inert and impermeable with respect to the vehicle and the heat-generating components. During use, the capsules are ruptured by mechanical force to allow the heatproducing components to react. The encapsulating material preferably has a melting point at or below the temperature produced when the heat-generating components react, whereby (a) the capsule fragments are readily dispersed in the composition to produce a smooth preparation in use, (b) the heating may be prolonged by using excess of the heat-generating components and initially rupturing only a portion of the capsules, (c) the heating may be raised to a desired level over a prolonged period by incorporating the heat-generating components in a plurality of thermoplastic capsules which have sequentially higher melting points, e.g. 120 F., 140 F. and so on. Any heat-generating components may be used provided they are non- toxic and non-irritating. Preferred are mixtures of (a) oxidizing agents, e.g. chlorates, perchlorates, permanganates, persulphates, peroxides, nitrates, metal oxides and perborates and (b) reducing agents, e.g. magnesium, zinc, aluminium, sulphites, thiosulphates, aldehydes, glycols and derivatives of thiobarbituric acid. A shaving cream formulation contains 1-phenyl- 5 - ethyl - 2 - thiobarbituric acid (reductant), ammonium molybdate tetrahydrate (catalyst) and aqueous hydrogen peroxide encapsulated in beeswax as the heat-producing components. A single-use packet (Figs. 1 and 2) comprises an enclosed chamber containing the self-heating composition and having at least one resilient wall and a dispensing opening which is closed off by a removable closure. Specification 1,088,301 is referred to.
It is known that microtrauma exists in the thigh muscles after long-distance running such as the half-marathon. Moreover, training characteristics of long-distance runners may influence the specificity of the distribution of muscle fiber types in the thigh and affect muscle responses to lipid metabolism. However, the specific changes in microtrauma and intramuscular lipid in thigh muscles after a half-marathon are unknown. A cohort of 20 healthy recreational marathon runners was recruited to complete a half-marathon. MRI T2 mapping and 6-echo q-Dixon sequences were employed at baseline (P1), 2-3 h after running (P2), and 1 day after running (P3). Inflammatory markers (the T2 values) and intramuscular fat fraction (the proton density fat fraction, PDFF) were measured in thigh muscles to detect microtrauma and intramuscular lipid changes, respectively. One-way analysis of variance showed significant time effects for T2 values and PDFF. Post hoc analysis of the 14 datasets collected at three time points revealed significantly higher T2 values in all thigh muscles after running (all p < 0.05). Significant differences in T2 values persisted for all thigh muscles at P3 compared to P1 (all p < 0.05). The PDFF of the vastus lateralis and vastus medialis was significantly decreased at P2 compared to P1 (p < 0.05). No significant differences in PDFF were observed for the thigh muscles at P3 compared to P1. The manifestations of inflammation edema and intramuscular lipid investigated through MRI may offer valuable insights for recreational marathon runners regarding the lower limb movement characteristics during half-marathon running.
The invention discloses a fructus gleditsiae hair conditioner, which is characterized in that: the ructus gleditsiae hair conditioner is prepared from raw materials of, by weight: 0.1 to 1.5% of a fructus gleditsiae extract; 0.1 to 2% of a Chinese angelica extract; 0.01 to 0.3% of cantharides tincture; 5 to 8% of glycerol; 0.5 to 1% of polyvinyl alcohol; 0.01 to 1% of an antiseptic, an essence, and a pigment; and balance of deionized water. The hair conditioner provided by the invention has a delicate and smooth quality and an aromatic smell. With the hair conditioner, cephalic blood capillaries can be extended, hair nutrition can be enhanced, and hair toughness can be improved. The hair conditioner provides active protecting effects for damaged hairs. With the hair conditioner, frequencies of hair nursing can be substantially reduced; and hair loss and broken hairs can be substantially reduced. After hair nursing, the hairs are black, bright, soft and smooth; and the duration of the effects is substantially prolonged. With the hair conditioner, superfluous fat can be removed, and obstructed hair follicles can be cleared. The hair conditioner provides excellent effects of hair-loss preventing and hair blackening, and brings no irritation to scalps.
The present invention relates to a multi-purpose bio-material useful as a bone filler, bio-adhesive, bone cement and bone graft. One preferred embodiment of the present invention generally comprises: potassium phosphate, a metal oxide (i.e. MgO), a calcium containing compound, a sugar and an aqueous solution. Exemplary calcium containing compounds include but are not limited to tri-calcium phosphates. The present invention is particularly useful as a bio-adhesive for bone, ligament, and other soft tissue and has surprising and unexpected osteoproliferative effects. The composition can be used for a variety of other uses.
Participants are randomly assigned to an 8 week SMT treatment group conducted by certified physical therapists. Immediately before and after the treatment sessions along with midway through the treatment (after 4 sessions), participants will undergo the placebo/naloxone administration intervention to assess mechanisms of SMT or MT-related changes.
Oral contraceptives have been shown to increase both the relative and attributable risks of cerebrovascular events (thrombotic and hemorrhagic strokes), although, in general, the risk is greatest among older (>35 years), hypertensive women who also smoke. Hypertension was found to be a risk factor for both users and nonusers, for both types of strokes, while smoking interacted to increase the risk for hemorrhagic strokes. Transient ischemic attacks have also been associated with oral contraceptive use. 

In a large study, the relative risk of thrombotic strokes has been shown to range from 3 for normotensive users to 14 for users with severe hypertension. The relative risk of hemorrhagic stroke is reported to be 1.2 for nonsmokers who used oral contraceptives, 2.6 for smokers who did not use oral contraceptives, 7.6 for smokers who used oral contraceptives, 1.8 for normotensive users and 25.7 for users with severe hypertension. The attributable risk is also greater in older women. Oral contraceptives also increase the risk for stroke in women with other underlying risk factors such as certain inherited or acquired thrombophilias. Women with migraine (particularly migraine/headaches with focal neurological symptoms such as aura) who take combination oral contraceptives may be at an increased risk of stroke. (See CONTRAINDICATIONS).
In this arm, participants will be given access to the course material shortly after eligibility criteria is confirmed. They will be asked to complete post-measures questionnaires at 4 weeks and 8 weeks following completion of the course material.
Chagas' disease reactivation leading to monophasic acute or subacute meningoencephalitis or space-occupying lesions is a well-described AIDS-defining condition in Latin America. We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic disease.
Participants in the treatment group are required to wear the HAs for at least 3 hours per day, with 24 days per month. Additionally, they will receive regular counseling and lifestyle education from their physicians.
A single dose of Recombinant Human Somatropin - Hormotrop is administered. The pain intensity is evaluated using visual analogue scale (0-10cm) and record the incidence of adverse events.
Fermented red ginseng (FRG) enhances the bioactivity and bioavailability of ginsenosides, which possess various immunomodulatory, antiaging, anti-obesity, and antidiabetic properties. However, the effects of FRG extract on muscle atrophy and the underlying molecular mechanisms remain unclear. This study aimed to elucidate the effects of FRG extract on muscle atrophy using both in vitro and in vivo models. In vitro experiments used dexamethasone (DEX)-induced C2C12 myotubes to assess cell viability, myotube diameter, and fusion index. In vivo experiments were conducted on hind limb immobilization (HI)-induced mice to evaluate grip strength, muscle mass, and fiber cross-sectional area (CSA) of the gastrocnemius (GAS), quadriceps (QUA), and soleus (SOL) muscles. Molecular mechanisms were investigated through the analysis of key signaling pathways associated with muscle protein synthesis, energy metabolism, and protein degradation. FRG extract treatment enhanced viability of DEX-induced C2C12 myotubes and restored myotube diameter and fusion index. In HI-induced mice, FRG extract improved grip strength, increased muscle mass and CSA of GAS, QUA, and SOL muscles. Mechanistic studies revealed that FRG extract activated the insulin-like growth factor 1/protein kinase B (Akt)/mammalian target of rapamycin signaling pathway, promoted muscle energy metabolism via the sirtuin 1/peroxisome proliferator-activated receptor gamma-coactivator-1α pathway, and inhibited muscle protein degradation by suppressing the forkhead box O3a, muscle ring-finger 1, and F-box protein (Fbx32) signaling pathways. FRG extract shows promise for ameliorating muscle atrophy by modulating key molecular pathways associated with muscle protein synthesis, energy metabolism, and protein degradation, offering insights for future drug development.