anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a salvia miltiorrhiza toothpaste prepared from the raw materials of, by weight, 5-15 parts of a salvia miltiorrhiza extract, 1-5 parts of a pilose asiabell root extract 1-5 parts of a ginkgo leaf extract, 1-5 parts of a lotus leaf extract, 1-5 parts of a tuber fleeceflower root extract, 1-5 parts of a wenchow turmeric root tuber extract, and 60-90 parts of a toothpaste substrate. The traditional Chinese medicines in the toothpaste provides synergetic effects of blood circulation activating, stasis removing, qi promoting, pain relieving, clear ascending, turbid descending, blood nourishing, and yin nourishing. Through daily teeth brushing, the medicines are dissolved in saliva, and penetrate, diffuse, and are absorbed through mouth mucosa, sublingual capillaries, and meridian points. Medicine breakage caused by gastrointestinal tract, liver, and kidney is avoided, and the medicines can directly enter blood circulation. Therefore, an effect is provided for cardiovascular and cerebrovascular diseases that both the root cause and symptoms are treated. The toothpaste is used for replacing long-term medication of cardiovascular and cerebrovascular disease patients.
The loss of functional beta-cell mass in diabetes is directly linked to the development of diabetic complications. Although dietary flavonoids have demonstrated antidiabetic properties, their potential effects on pancreatic beta-cell preservation and their synergistic benefits with antidiabetic drugs remain underexplored. We have developed a potential functional food enriched in flavonoids by combining cocoa powder and carob flour (CCB), which has shown antidiabetic effects. Here, we investigated the ability of the CCB, alone or in combination with metformin, to preserve pancreatic beta cells in an established diabetic context and their potential synergistic effect. Zucker diabetic fatty rats (ZDF) were fed a CCB-rich diet or a control diet, with or without metformin, for 12 weeks. Markers of pancreatic oxidative stress and inflammation, as well as relative beta-cell mass and beta-cell apoptosis, were analyzed. Results demonstrated that CCB feeding counteracted pancreatic oxidative stress by enhancing the antioxidant defense and reducing reactive oxygen species. Moreover, the CCB suppressed islet inflammation by preventing macrophage infiltration into islets and overproduction of pro-inflammatory cytokines, along with the inactivation of nuclear factor kappa B (NFκB). As a result, the CCB supplementation prevented beta-cell apoptosis and the loss of beta cells in ZDF diabetic animals. The observed additive effect when combining the CCB with metformin underscores its potential as an adjuvant therapy to delay the progression of type 2 diabetes.
ETHNOPHARMACOLOGICAL RELEVANCE: β-tubulin is a skeletal protein of sinoatrial node cells (SANCs) that maintains the physiological structure of SANCs and inhibits calcium overload. Tongyang Huoxue decoction (TYHX) is widely used to treat sick sinus syndrome (SSS) owing to its effects on calcium channels regulation and SANCs protection.
AIM OF THE STUDY: This study focuses on the mechanism of TYHX in improving the hypoxia/reoxygenation (H/R)-induced disequilibrium of calcium homeostasis in SANCs via regulating β-tubulin.
MATERIALS AND METHODS: Real-Time PCR (RT-PCR) and Western Blot were adopted to detect the mRNA and protein expression levels of calcium channel regulatory molecules. Laser confocal method was employed to examine β-tubulin structure and fluorescence expression levels in SANCs, as well as calcium wave and calcium release levels.
RESULTS: It was found that the fluorescence expression level decreased and the β-tubulin structure of SANCs was damaged after H/R treatment. The mRNA and protein expression levels of SERCA2a/CaV1.3/NCX and β-tubulin decreased, while the mRNA and protein expression of RyR2 increased. The results of calcium wave and calcium transient experiments showed that the fluorescence expression level of Ca2+ increased and calcium overload occurred in SANCs. After treatment with TYHX, the mRNA and protein expression levels of SERCA2a/CaV1.3/NCX and β-tubulin increased, while the mRNA and protein expression levels of RyR2 decreased and the cell structure was restored. Interestingly, the regulation of TYHX on calcium homeostasis was further enhanced after Ad-β-tubulin treatment and counteracted after siRNA-β-tubulin treatment. These results suggest that TYHX could maintain calcium homeostasis via regulating β-tubulin, thus protecting against H/R-induced SANCs injury, which may be a new target for SSS treatment.
Patients receive standard of care treatment comprising either docetaxel IV and dexamethasone IV over 30 minutes on day 1 or docetaxel IV, dexamethasone IV over 30 minutes, and ramucirumab IV over 60 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Facebook group, Health Chat, which provides information via posts within the private group about a wide variety of health topics (e.g. tobacco use, body image), but does not include any content about indoor tanning. The designated number of posts (25%) assigned to the indoor tanning content in the intervention group will be assigned to prescription drug use in the control arm. In order to keep number and frequency of posts standardized between the two groups, prescription drug use was selected to replace the indoor tanning content for the control arm.
The method relates to the co-culturing of two cell cultures in two cell culture chambers such that the cellular products produced by the co-cultured cells are exchanged between the two cell culture chambers. The apparatus for culturing the cells contains two cell culture chambers separated by a microfiltration membrane which is permeable to medium, gases, and cellular products, and is impermeable to cells. A culture medium supply chamber is adjacent to and separated from the first cell culture chamber by a dialysis membrane which is permeable to medium and gases. The exterior portion of the second cell culture contains a gas-exchange membrane which allows gas exchange between the apparatus and the environment. The apparatus can be in a modular form where the first and second cell culture chambers form one module which is detachable from the culture medium supply chamber which forms the second module. The method and apparatus allows the exchange of media, gases, and cellular products between the two cell cultures while preventing direct contact of the two cell cultures.
PCT No. PCT/FR95/01253 Sec. 371 Date Mar. 28, 1997 Sec. 102(e) Date Mar. 28, 1997 PCT Filed Sep. 28, 1995 PCT Pub. No. WO96/10045 PCT Pub. Date Apr. 14, 1996The invention relates to a chain end functionalised polymer of formula: in which: the polymer chain (P) is a hydrophobic chain obtained by radical polymerisation of at least one monomer, R represents a hydrogen atom or a linear or branched hydrocarbon chain having 1 to 8 carbon atoms optionally substituted with at least one group selected from CO2, NH2, OH or a phenyl group, itself being optionally substituted, A and B, identical or different, each represent a single bond, a saturated or unsaturated linear or branched hydrocarbon chain having from 1 to 16 carbon atoms, it being possible for it to contain an amide bond or a peptide chain having 2 to 4 amino acids, particularly natural amino acids, the NH2 and/or COOH groups being free or salified. The invention also relates to the use of the above products as surfactants and more particularly as wetting agents, dispersing agents of solid particles and for preparing microdispersions of polymers, in particular microgels and microlatexes. The invention also relates to cosmetic compositions incorporating these products and notably nail varnishes.
Methods for providing secure access to health related information of a patient or resident at a care environment facility are provided. In one aspect, a method includes receiving a list of residents. The method includes generating a unique token for each authorized recipient correspondingly associated with a resident listed on the list of residents. The method includes receiving a request from a user device to access medical information associated with the resident listed on the list of residents. The method includes determining whether to authenticate the request based on the unique token. The method includes facilitating communication, responsive to authenticating the request, between the user device and an electronic medical records server for transmitting the medical information associated with the resident to the user device. Systems and machine-readable media are also provided.
A silent state (a wave file made without sound) is applied for at least 20 minutes from 20 minutes before arrival to the operating room. The sound generator is a smartphone device, set the volume (at a volume corresponding to 60 dB in the experimental group), and hang it on the transport bed. Upon arrival in the operating room, before anesthesia, the volume is adjusted to 0.
Participants randomized to the control arm (n=80) will have limited access to certain components of the Baby-Feed web application, such as the online infant FFQ to complete it at the same intervals (before the 4-month, 6-month, and 9-month well-child visits) and infant's weight and length as recorded in the well-child visits, but without any automatic results or feedback. The control group will have a separate user access to the Baby-Feed web application that only allows them to complete the required information without being able to see results, feedback, tracking, recommendations, or resources.
Disclosed is a sperm producing tablet. The tablet is a novel product at present and is used for curing male sterility. The male sterility is caused by abnormal sperms, sperms are active substances which are produced in testicles, and in life, male sterility is often caused by few sperm or aspermia. The tablet is prepared by 25 Chinese medicinal herbs such as fleece-flower roots, medlars, dodder and shizandra berries. The table contains various plant polysaccharide components, polysaccharide components contain various trace elements, trace elements can promote sperm growth and sperm viability can be strengthened. Therefore, the tablet can cure sterility caused by few male sperm and male aspermia well.
The present disclosure provides computer-implemented methods for annotating a query nucleic acid sequence. Methods of the present disclosure provide for the accurate annotation of nucleic acid sequences having functional or other important implications. Subject methods also provide for generating an assembly for longer DNA sequences that comprise shorter annotated sequences. Also provided are methods for monitoring the genetic material within a defined physical location. Such methods may find use in a variety of applications, for example, monitoring the spread of a pandemic, monitoring the prevalence of antibiotic resistance, provide guidance in making clinical decisions, and others. Also provided are related systems and non-transitory computer-readable recording media.
Background: Current treatments with urate-lowering therapy (ULT) are effective for most patients with gout. However, approximately 10% of these patients do not respond well to ULT and develop chronic tophus lesions. Objective: This study aimed to evaluate the efficacy of surgery involving the shaver technique against chronic tophus lesions. Methods: This single-center, retrospective cohort study included 217 patients who had cumulatively undergone 303 shaver-assisted procedures between 2002 and 2018. Surgical outcomes were assessed in terms of the length of hospital stay (LOS) and wound healing time. Results: LOS and wound healing time were longer in patients with a preoperative tophus infection and lower extremity lesions than in those without infection and with upper extremity lesions (respectively, LOS: 12.7 vs. 8.6 days; wound healing time: 22.7 vs. 16.3 days). However, factors such as age, sex, body mass index, renal function, or uricemia level exerted no significant effect on surgical outcomes. Conclusion: Surgery involving the shaver technique should be performed before tophus infection. Clinical outcomes tend to be better for upper extremity lesions than for lower extremity lesions.
Three different 30-minute modalities of deventilation will be performed in a randomized order in each patient. Washout periods of 30 minutes will occur between tested modalities.
Bifidobacterium animalis subsp. lactis BLa80 is a new probiotic strain with extensive applications in food products both domestically and internationally. Given the rising consumption of this probiotic, its safety assessment is increasingly crucial in the food industry. This study evaluates the safety of strain BLa80 using a combination of in vitro and in vivo assays along with genomic analysis. Methods included exposing the strain to artificial gastric and intestinal fluids, as well as a medium containing bile salts, to stimulate human digestive conditions. The strain showed high tolerance to gastric fluid at pH of 2.5 and to 0.3 % bile salts. It maintained a 99.92 % survival rate in intestinal fluid. Additional tests assessed hemolytic activity, antibiotic susceptibility (revealing sensitivity to 7 antibiotics), and biogenic amine production using HPLC-ELSD, confirming the absence of histamine, and other harmful amines. Bile salt hydrolase activity was demonstrated qualitatively, and metabolic byproducts were quantitatively analyzed using a D-/l-lactic acid assay kit, showing that BLa80 produces 1.48 mg/mL of l-lactic acid and no harmful d-lactic acid. Genomic analysis confirmed the absence of virulence or pathogenicity genes, and a 90-day oral toxicity study in rats confirmed no toxic effects at various doses. Overall, these findings support the safety classification of the strain BLa80.
A fluid sampling device and a method is provided for collecting body fluid samples such as blood without the intervention of medically trained personnel. The body fluid sampling device having a sample containment chamber made of a material having a thermal inertia permitting the maintenance of sample temperature over a known period of time. Optionally an isolating cover or sleeve may slide in place by a mechanism triggered by thermal contraction of an element after the device has reached a sufficiently low temperature in a patients refrigerator. Associated methods are provided to ensure hermetic transport of the collected body fluid sample to an analysis lab. Also disclosed is a device and app combination for drug or vaccine injection, the app including means to allow for verification of the patient's ID and/or the particular device used. The device my be equipped with geo-localization and long-range communication capabilities.
Photoactivatable dendrimers and hydrogels formed therefrom include dendrimers to which polymer chains (e.g. polyethylene glycol, PEG) have been conjugated; and reactive photoactivatable groups attached to terminal functional groups of the polymer chains (e.g. hydroxyls of PEG). Exposure to a suitable wavelength of light activates the photoactivatable groups, which then crosslink with one another, thereby forming a hydrogel. The hydrogel may also include one or more agents of interest; or, in some embodiments, nanoparticles containing one or more agents of interest may be dispersed in the hydrogel. These formulations are well-suited for sustained or prolonged delivery of active agents, e.g. for the treatment of glaucoma by the sustained delivery of anti-glaucoma agents directly to the eye.
Patients with severe mental disorders such as bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) show a substantial reduction in life expectancy, increased incidence of comorbid medical conditions commonly observed with advanced age and alterations of aging hallmarks. While severe mental disorders are heritable, the extent to which genetic predisposition might contribute to accelerated cellular aging is not known. We used bivariate causal mixture models to quantify the trait-specific and shared architecture of mental disorders and 2 aging hallmarks (leukocyte telomere length [LTL] and mitochondrial DNA copy number), and the conjunctional false discovery rate method to detect shared genetic loci. We integrated gene expression data from brain regions from GTEx and used different tools to functionally annotate identified loci and investigate their druggability. Aging hallmarks showed low polygenicity compared with severe mental disorders. We observed a significant negative global genetic correlation between MDD and LTL (rg = -0.14, p = 6.5E-10), and no significant results for other severe mental disorders or for mtDNA-cn. However, conditional QQ plots and bivariate causal mixture models pointed to significant pleiotropy among all severe mental disorders and aging hallmarks. We identified genetic variants significantly shared between LTL and BD (n = 17), SCZ (n = 55) or MDD (n = 19), or mtDNA-cn and BD (n = 4), SCZ (n = 12) or MDD (n = 1), with mixed direction of effects. The exonic rs7909129 variant in the SORCS3 gene, encoding a member of the retromer complex involved in protein trafficking and intracellular/intercellular signaling, was associated with shorter LTL and increased predisposition to all severe mental disorders. Genetic variants underlying risk of SCZ or MDD and shorter LTL modulate expression of several druggable genes in different brain regions. Genistein, a phytoestrogen with anti-inflammatory and antioxidant effects, was an upstream regulator of 2 genes modulated by variants associated with risk of MDD and shorter LTL. While our results suggest that shared heritability might play a limited role in contributing to accelerated cellular aging in severe mental disorders, we identified shared genetic determinants and prioritized different druggable targets and compounds.
FLT3 tyrosine kinase inhibitors (TKIs) have clinical efficacy for patients with FLT3-mutated AML (acute myeloid leukemia), but their impact is limited by resistance in the setting of monotherapy and by tolerability problems when used in combination therapies. FF-10101 is a novel compound that covalently binds to a cysteine residue near the active site of FLT3, irreversibly inhibiting receptor signaling. It is effective against most FLT3 activating mutations, and, unlike other inhibitors, is minimally vulnerable to resistance induced by FLT3 ligand. We conducted a phase 1 dose escalation study of oral FF-10101 in patients with relapsed and/or refractory AML, the majority of whom harbored FLT3-activating mutations and/or had prior exposure to FLT3 inhibitors. Fifty-four participants enrolled in cohorts receiving doses ranging from 10 to 225 mg per day and 50 to 100 mg twice daily (BID). The dose limiting toxicities were diarrhea and QT prolongation. Among 40 response-evaluable participants, the composite complete response rate was 10%, and the overall response rate (including partial responses) was 12.5%, including patients who had progressed on gilteritinib. Overall, 56% of participants had prior exposure to FLT3 inhibitors. The recommended phase 2 dose was 75 mg BID. FF-10101 potentially represents a next-generation advance in the management of FLT3-mutated AML. This trial was registered at www.ClinicalTrials.gov as #NCT03194685.
Pancreatic ductal adenocarcinoma (PDAC) incidence has increased with a high rate during the past few years (+4.7% per year between 2005 and 2012, source InfoCancer 2013). No cure is currently available for this deadly disease, with an overall survival \<5%. Survival can reach 20% when surgery is possible, giving the best chance to the patients. If patients present locally advance disease, it is crucial to quickly establish resectability to avoid unneeded and even deleterious surgery in patients with metastatic stages. It is also important to increase the rate of true R0 resection with effective preoperative therapy. However, when the cancer is suspected, neoadjuvant chemotherapies are often delayed because the mandatory histologic proof is difficult to make with non-informative biopsies. It is necessary to find new markers to help for rapid diagnosis that could allow neoadjuvant therapies and surgery when anatomo-pathologic proof is not available. New developments in the field of liquid biopsy hold great promise in providing valuable information for diagnosis assistance. The project will be run in two steps. First, several methods will be compared for tumor cell recovery after cell spiking in blood of non-cancer patients and pancreatic cell line onco-exosomes will characterized by flow cytometry. Second the best method will be used to detect and enumerate CTCs in 20 PDAC patients and 20 non-cancer patients. In parallel GPC1+ exosomes from patients' plasmas will be quantified. Diagnosis accuracy will be established and compared. Correlations between circulating tumor elements presence and clinical and biological parameters will be evaluated at the time of the diagnosis. Patient clinical outcome will be assessed according to initial circulating element quantification.
The invention discloses special Yao bath powder for pedicure. The special Yao bath powder comprises, by dry weight, powdery compositions of 1-2 parts of climbing groundsel herb, 0.2-2 parts of clinopodium chinensis, 0.2-2 parts of eclipta alba, 0.2-2 parts of tall hymenodictyon bark, 0.2-2 parts of sargentodoxa cuneata, 0.2-2 parts of garden balsam stems and the like and further can comprise one type or a plurality of types of paederia scandens, wild peach leaves, parabarium micranthum and sweet wormwood herb. Raw materials are mixed with one another according to dry weights to obtain the powdery compositions. A method for manufacturing the special Yao bath powder includes respectively grinding various clean and dry composition medicines without insect pests or mildew to obtain powder for standby application; uniformly mixing the powder of the composition medicines according to component proportions to obtain the compositions; quantitatively packaging the compositions by the aid of non-woven fabrics or gauze bags. The medicine powder is cooked in boiling water for 3-5 minutes when the special Yao bath powder is about to be used, then medicine liquid is poured into a foot bath bucket, the temperature of the medicine liquid is adjusted by the aid of cold water added into the foot bath bucket until the temperature is appropriate, and the feet of a user can be soaked in the medicine liquid to be bathed. The special Yao bath powder has the advantages that effects of removing dampness, toxicity and odor, relieving itching, destructing bacteria and preventing corrosion can be realized, obvious curative effects can be realized for foot diseases such as foot itching, foot odor, foot ulceration and eczema, and effects of curing and preventing the diseases, removing the odor, relieving the itching and preventing and treating the ulceration can be realized while the double feet of the user are bathed; the special Yao bath powder is made of pure herbal medicinal materials without chemical preparations, is nontoxic and harmless and is free of side effects, low in cost and easy to popularize, and the diseases can be treated when available and can be prevented when unavailable.