anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The recommended starting dosage of SPRYCEL for chronic phase CML is 100 mg administered orally once daily. The recommended starting dosage of SPRYCEL for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL is 140 mg administered orally once daily. Tablets should not be crushed or cut; they should be swallowed whole. SPRYCEL can be taken with or without a meal, either in the morning or in the evening. 

In clinical studies, treatment with SPRYCEL was continued until disease progression or until no longer tolerated by the patient. The effect of stopping treatment after the achievement of a complete cytogenetic response (CCyR) has not been investigated.
FIELD: medicine, biotechnology, microbiology. SUBSTANCE: method involves the submerged periodic culturing the selected strain of mycelial fungi with stable trait of intense germination of conidia and spores in flasks at shaking 100 rev/min using shuttle-apparatus at 27 C and by the directed biosynthesis using supplements of yeast extract in the concentration 0.5% taken in the amount 1 ml to the basic Saburo's medium. Control is carried out by recording maximal yield of allergen- -active components, accumulation of biomass, protein nitrogen and cytomorphological changes of mycelium in dynamics of culturing fungi. Filtrate of cultural fluid prepared by the developed method for growing fungal allergens shows high specificity and standardization in repeated studies that proved by testing in patients with atopic diseases in mycological clinic MAPO and medicinal institution of St. -Peterburgh and Russia. Allergens from mycelial fungi are used for immune diagnosis of mycogenic sensitization and allergy. EFFECT: improved culturing method, valuable medicinal properties of allergen. 2 dwg, 1 tbl, 1 ex
The present invention relates to a mineral health care food and a preparation method thereof. The mineral health care food is composed of medical stones and zeolite. Natural zeolite mines and medical stones are respectively crushed into fragments smaller than 5cm after impurities are removed, the fragments are washed by clear water and are dried by air naturally, the fragments are respectively processed into miropowder with the grain size of about 1 um by a raymond mill after air drying, disinfection is carried out by an ultraviolet disinfection instrument, and the food is packed after prepared by evenly mixing zeolite miropowder and medical stone powder according to the proportion of 76 to 84% of zeolite miropowder and 16 to 26% of medical stone powder after disinfection is carried out. The mineral health care food of the present invention has the functions of toxin elimination, health care, medical treatment and life extension. The present invention has obvious therapeutic efficacy especially to the kidney, the gstrointestinal tract, gynecological diseases and various kinds of phlogosis. In addition, the present invention also has obvious therapeutic efficacy to weight reduction and beautification and performs the functions of whole toxin elimination and detoxification.
The present invention relates to a composition for prevention or treatment of urinary tract infection. Particularly, the composition comprises  Orthosiphon spicatus  extract and  Strobilanthes crispa  extract. It may further comprise  Hibiscus sabdariffa  extract. The disclosed composition facilitates heat clearing and detoxification of the body. Besides, it helps to reduce swelling/edema and remove calculi by inducing diuresis. It also promotes the health of kidney and liver. The disclosed composition is substantially free of toxic side effects and requires relatively economical cost of production. Specifically, the disclosed composition is advantageous in inhibiting the formation of uric acid and treating gout while having a better effect in treating urinary tract infection or urinary tract stones with limited toxic side effects.
Neuropsychiatric disability is related to reduced ability to change in response to clinical interventions, e.g., plasticity. Study of biomarkers and interventional strategies for plasticity, however, are sparse. In this chapter, we focus on the serial frequency discrimination task (SFDT), which is sensitive to impairments in early auditory processing (EAP) and auditory learning and has been most thoroughly studied in dyslexia and schizophrenia. In the SFDT, participants are presented with repeated paired tones ("reference" and "test") and indicate which tone is higher in pitch. Plasticity during the SFDT is critically dependent upon interactions between prefrontal "cognitive control" regions, and lower-level perceptual and motor regions that may be detected using both fMRI and time-frequency event-related potential (TF-ERP) approaches. Additionally, interactions between the cortex and striatum give insights into glutamate/dopamine interaction mechanisms. The SFDT task has been utilized in the development of N-methyl-D-aspartate receptor (NMDAR) targeted medications, which significantly modulate sensory and premotor neurophysiological activity. Deficits in pitch processing play a critical role in impaired neuro- and social cognitive function in schizophrenia and may contribute to similar impairments in dyslexia. Thus, the SFDT may be ideal for development of treatments aimed at amelioration of neuro- and social cognitive deficits across neuropsychiatric disorders.
<P>PROBLEM TO BE SOLVED: To provide a medicine procurement supporting system capable of quickly procuring medicines without newly placing an order to a wholesale supplier and causing delay in procurement of medicines, even if the medicines which are not in stock are required in a dispensing pharmacy.  <P>SOLUTION: A terminal device 13 transmits sales history information to a management server apparatus 11. The management server apparatus 11 records the sales history information transmitted from each terminal device 13 in a database function 111. A user accesses the management server apparatus 11 from the terminal device 13 through the Internet, and enters medicine information to be retrieved in a medicine retrieval screen and depresses a retrieval button. Then, the management server apparatus 11 retrieves the sales history information, and infers the dispensing pharmacies where the medicines can be procured. Thus, a list of the dispensing pharmacies are displayed at the terminal device 13. The user makes a procurement request to the dispensing pharmacy where the required medicines can be procured from the list of the dispensing pharmacies where the medicines can be procured.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
BACKGROUND: Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.
METHODS: We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome.
RESULTS: In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.
CONCLUSIONS: This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association.
Disclosed are a permanent wave liquid composition and a method for molding a permanent wave. A natural mineral mixture solution is applied to hairs containing moisture, and a permanent agent mixed with a hair permanent reducing agent and a natural mineral mixture is coated on the hairs. At the same time as, before, or after the same, while a mechanical tensile force is applied to the hairs using a hair molding member, heating is performed for 20-50 minutes so that the hairs are naturally dried and a permanent wave is completed. An oxidizing agent for neutralizing the reducing agent is not separately used. The natural mineral mixture includes natural organic ion minerals, saponine, and polyphenol. It is preferable that the mixed ratio of the reducing agent, natural organic ion minerals, saponine, and polyphenol are respectively 77.0-95.0 wt%, 3.5-20.0 wt%, 1.0-5.0 wt%, and 0.1-1.0 wt%. An oxidizing agent is not used, so that oxidizing agent side effects can be prevented, and a permanent wave molding time can be reduced. By means of the natural organic ion minerals and polyphenol, hair damage can be minimized. Gloss, softness, and elasticity are provided to the hairs having the permanent wave. Also, permanent sustaining strength is improved.
At the completion of pancreatic resection, the cut surface of the pancreas is covered with two layers of Albu-Green solder and one layer of D-Albumin lamina, all welded with the laser. The 60 Watt custom 810nm diode laser, is set to deliver continuous energy with laser irradiation power of approximately 150 W/cm2 with a Fluence of 90 J/cm2. During soldering the tip of the custom hand piece with top hat beam profile is held 1-2 cm from the wound surface to generate a 5mm spot size. Albu-Green Solder is observed to convert from a liquid green state to a solid white crust when the laser is activated indicating the completion of welding and providing a visual cue to the operator. The amount of Albu-Green solder and size of the denatured albumin lamina used is documented. The total laser tissue welding time for the three layers and the laser tissue welding time in seconds per cm2 is documented.
Schistosomiasis, a parasite infectious disease caused by Schistosoma japonicum, often leads to egg granuloma and fibrosis due to the inflammatory reaction triggered by egg antigens released in the host liver. This study focuses on the role of the egg antigens CP1412 protein of S. japonicum (SjCP1412) with RNase activity in promoting liver fibrosis. In this study, the recombinant egg ribonuclease SjCP1412, which had RNase activity, was successfully prepared. By analysing the serum of the population, it has been proven that the anti-SjCP1412 IgG in the serum of patients with advanced schistosomiasis was moderately correlated with liver fibrosis, and SjCP1412 may be an important antigen associated with liver fibrosis in schistosomiasis. In vitro, the rSjCP1412 protein induced the human liver cancer cell line Hep G2 and liver sinusoidal endothelial cells apoptosis and necrosis and the release of proinflammatory damage-associated molecular patterns (DAMPs). In mice infected with schistosomes, rSjCP1412 immunization or antibody neutralization of SjCP1412 activity significantly reduced cell apoptosis and necroptosis in liver tissue, thereby reducing inflammation and liver fibrosis. In summary, the SjCP1412 protein plays a crucial role in promoting liver fibrosis during schistosomiasis through mediating the liver cells apoptosis and necroptosis to release DAMPs inducing an inflammatory reaction. Blocking SjCP1412 activity could inhibit its proapoptotic and necrotic effects and alleviate hepatic fibrosis. These findings suggest that SjCP1412 may be served as a promising drug target for managing liver fibrosis in schistosomiasis japonica.
Background and Objectives: Functional gastric stenosis, a consequence of sleeve gastrectomy, is defined as a rotation of the gastric tube along its longitudinal axis. It is brought on by gastric twisting without the anatomical constriction of the gastric lumen. During endoscopic examination, the staple line is deviated with a clockwise rotation, and the stenosis requires additional endoscopic manipulations for its transposition. Upper gastrointestinal series show the gastric twist with an upstream dilatation of the gastric tube in some patients. Data on its management have remained scarce. The objective was to assess the efficacy and safety of endoscopic balloon dilatation in the management of functional post-sleeve gastrectomy stenosis. Patients and Methods: Twenty-two patients with functional post-primary-sleeve-gastrectomy stenosis who had an endoscopic balloon dilatation between 2017 and 2023 were included in this retrospective study. Patients with alternative treatment plans and those undergoing endoscopic dilatation for other forms of gastric stenosis were excluded. The clinical outcomes were used to evaluate the efficacy and safety of balloon dilatation in the management of functional gastric stenosis. Results: A total of 45 dilatations were performed with a 30 mm balloon in 22 patients (100%), a 35 mm balloon in 18 patients (81.82%), and a 40 mm balloon in 5 patients (22.73%). The patients' clinical responses after the first balloon dilatation were a complete clinical response (4 patients, 18.18%), a partial clinical response (12 patients, 54.55%), and a non-response (6 patients, 27.27%). Nineteen patients (86.36%) had achieved clinical success at six months. Three patients (13.64%) who remained symptomatic even after achieving the maximal balloon dilation of 40 mm were considered failure of endoscopic dilatation, and they were referred for surgical intervention. No significant adverse events were found during or following the balloon dilatation. Conclusions: Endoscopic balloon dilatation is an effective and safe minimally invasive procedure in the management of functional post-sleeve-gastrectomy stenosis.
Participants will receive clinical pharmacist management of diabetes. Those participants who meet their HbA1c goal at 6 months will continue with maintenance diabetes management. This includes routine primary care with the primary care provider, routine medication management, and traditional home glucose monitoring. For those not meeting goals in HbA1c they will be randomized again to receive Pharmacist + CGM or receive Pharmacist + CGM + Community Health Worker (CHW) support.
Schistosomiasis is the second leading parasitic disease worldwide, after malaria. Liver fibrosis is the most serious complication of schistosomiasis mansoni which can lead to reduced work capacity and early death in endemic countries. There is, however, limited knowledge on the development of liver fibrosis and the differential patterns morbidity observed in endemic communities. Our preliminary cross-sectional study in Ethiopia seems to indicate that serum levels of antioxidants may influence the development of fibrosis. The present project is a translational study combining basic antioxidant laboratory work with is a randomised double blinded placebo controlled prospective study in endemic areas in Ethiopia, investigating the role of food based antioxidant supplements on the outcome of anti-schistosomal chemotherapy with regards to the extent of fibrosis reversal. In addition, analysis of dietary intakes of antioxidants among communities with comparable levels of S. mansoni infection but with differing levels of schistosomal periportal fibrosis will be undertaken to compare serum levels of antioxidants and prevalence of liver fibrosis. Furthermore we plan to assess development of schistosomal peri-portal fibrosis in a cohort of students established 9 years back who had comparable levels of community prevalence of schistosomiasis but with differing access to fruits and vegetables. Research on this topic has a high priority globally which is in line with the millennium development goals. Knowledge in this field will also add to our understanding of fibrosis development in general and to the efficacy of clinical treatment of schistosomiasis in particular.
The present invention relates to methods employing soluble multivalent activating agents for the selective in vitro and ex vivo activation and expansion ?? T-cell population(s), including specific ?? T-cell subpopulation(s) of interest and admixtures thereof, and methods for using the same for therapeutic purposes. Methods and compositions of the disclosure are useful in the treatment of various cancers, infectious diseases, and immune disorders.
BACKGROUND: Developmental and Epileptic Encephalopathies (DEEs) are defined by drug-resistant seizures and neurodevelopmental disorders. Over 50% of patients have a genetic cause. Studies have shown that patients with DEEs, regardless of genetic diagnosis, experience a central visual function disorder known as Cerebral (cortical) Visual Impairment (CVI). The prevalence of CVI in DEE patients is currently unknown. A quantitative synthesis of existing data on the prevalence rates of this condition would aid in understanding the magnitude of the problem, outlining future research, and suggesting the need for therapeutic strategies for early identification and prevention of the disorder.
METHODS: The protocol followed the PRISMA-P statement for systematic review and meta-analysis protocols. The review will adhere to the JBI Manual for Evidence Synthesis (Systematic Reviews of Prevalence and Incidence) and use the CoCoPop framework to establish eligibility criteria. We will conduct a comprehensive search of several databases, including MEDLINE, EMBASE, Science Direct, Scopus, PsychINFO, Wiley, Highwire Press, and Cochrane Library of Systematic Reviews. Our primary focus will be determining the prevalence of cerebral visual impairments (Condition) in patients with developmental and epileptic encephalopathy (Population). To ensure clarity, we will provide a narrative summary of the risk of bias in the studies we include. The Cochrane Q statistic will be used to assess heterogeneity between studies. If the quantitative synthesis includes more than 10 studies, potential sources of heterogeneity will be investigated through subgroup and meta-regression analyses. Meta(bias)es analysis will also be performed. The quality of evidence for all outcomes will be evaluated using the Grading of Recommendations Assessment Development and Evaluation (GRADE) working group methodology.
DISCUSSION: This protocol outlines a systematic review and meta-analysis to identify, collect, evaluate, and integrate epidemiological knowledge related to the prevalence of CVI in patients with DEEs. To the best of our knowledge, no other systematic review and meta-analysis has addressed this specific issue. The results will provide useful information for understanding the extent of the problem, outlining future research, and suggesting the need for early identification strategies.
SYSTEMATIC REVIEW REGISTRATIONS: This Systematic Review Protocol was registered in PROSPERO (CRD42023448910).
OBJECTIVE: Meningiomas invading the intracranial venous sinuses may cause intracranial venous hypertension, papilledema, and visual compromise. Sinus resection and graft reconstructions, however, add significant complexity to tumor surgery, with the potential for increased morbidity. In this study, the authors explored whether venous sinus stenting might provide an alternative means of controlling venous hypertension that would be sustainable over the long term.
METHODS: The authors performed a retrospective review of all 16 patients with intracranial meningiomas who underwent stenting at their institution for venous sinus compromise. At presentation, all had headache and 9 had papilledema. Thirteen patients had 1 meningioma and 3 had 2 or more. Three patients had had previous tumor resection and radiotherapy. One patient had been treated with a lumboperitoneal shunt and radiotherapy. The median length of clinical follow-up was 8 years (range 4 months-18 years).
RESULTS: Venous sinus narrowing was often not confined to the site of meningioma, and bilateral transverse sinus narrowing, reminiscent of that seen in idiopathic intracranial hypertension, was present in 7 patients with sagittal sinus meningiomas. Eleven patients had stents placed solely across sinus narrowing caused by meningioma. Five patients had additional stents placed at other sites of venous narrowing at the same time: in one of these patients, a stent was placed across a defect in the sagittal sinus caused by previous surgery, and in the 4 other patients, stents were placed across nontumor narrowings of the transverse sinuses. In 1 patient, the jugular vein was also stented. Nine patients developed symptomatic in-stent restenosis at the meningioma site. Eight had further stenting procedures with variable success in restoring the in-stent lumen. The remaining patient, with a late partial relapse, is being reinvestigated. Papilledema resolved in all patients after stenting. Six patients experienced prolonged and very substantial relief of all symptoms. Five patients had persistent headache despite restoration of the sinus lumen. Five had persistent symptoms associated with resistant in-stent stenosis. There were no significant complications from any of the diagnostic or therapeutic procedures.
CONCLUSIONS: In patients who are symptomatic with meningiomas obstructing the venous sinuses, successful stenting of the affected segment can give a good outcome, especially in terms of relieving papilledema. However, further procedures are often necessary to maintain stent patency, other areas of venous compromise frequently coexist, and some patients remain symptomatic despite apparently successful treatment of the index lesion. Long-term surveillance is a requirement.
The invention relates to penicillium citrinum-derived penicitrinine A as well as application thereof to preparation of drugs for resisting human colorectal carcinoma. The compound has the effect of restraining human colorectal carcinoma cell proliferation. The structural formula of the compound is shown in the description. According to the invention, through fermenting culture of penicillium citrinum IBPT-5, a fermentation product is obtained, and then the compound is separated and purified from the fermentation product. Experiment results confirm that the compound has better antitumor activity on human colorectal carcinoma cells such as SW-480, SW-620 and LOVO. The penicillium citrinum-derived penicitrinine A can be applied to preparation of human colorectal carcinoma cell proliferation inhibition drugs or antitumor drugs to be used for research on human colorectal carcinoma.
This two-group parallel randomized controlled study was conducted with pregnant women admitted to the pregnancy follow-up outpatient clinics of a university hospital in northern Turkey. The study was completed with 80 pregnant women in their second trimester, 40 pregnant women each in the intervention and control groups. Pregnant women in the intervention group received online video-assisted education which demonstrated first meeting of the mother-baby and first breastfeeding in addition to receiving counselling on breastfeeding. Pregnant women in the control group did not receive any intervention other than routine care. Data were collected face-to-face with the breastfeeding self-efficacy scale at the beginning of the study and two weeks later. In data analysis, chi-square test was used for categorical variables, independent sample t-test was used for continuous variables and intergroup comparison, and paired sample t-test was used for intragroup comparison.