anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: In observational studies, there exists an association between obesity and epigenetic age as well as telomere length. However, varying and partially conflicting outcomes have notably arisen from distinct studies on this topic. In the present study, two-way Mendelian randomization was used to identify potential causal associations between obesity and epigenetic age and telomeres.
METHODS: A genome-wide association study was conducted using data from individuals of European ancestry to investigate bidirectional Mendelian randomization (MR) regarding the causal relationships between obesity, as indicated by three obesity indicators (body mass index or BMI, waist circumference adjusted for BMI or WCadjBMI, and waist-to-hip ratio adjusted for BMI or WHRadjBMI), and four epigenetic age measures (HannumAge, HorvathAge, GrimAge, PhenoAge), as well as telomere length. To assess these causal associations, various statistical methods were employed, including Inverse Variance Weighted (IVW), Weighted Median, MR Egger, Weighted Mode, and Simple Mode. To address the issue of multiple testing, we applied the Bonferroni correction. These methods were used to determine whether there is a causal link between obesity and epigenetic age, as well as telomere length, and to explore potential bidirectional relationships. Forest plots and scatter plots were generated to show causal associations between exposures and outcomes. For a comprehensive visualization of the results, leave-one-out sensitivity analysis plots, individual SNP-based forest plots for MR analysis, and funnel plots were included in the presentation of the results.
RESULTS: A strong causal association was identified between obesity and accelerated HannumAge, GrimAge, PhenoAge and telomere length shrinkage. The causal relationship between WCadjBMI and PhenoAge acceleration (OR: 2.099, 95%CI: 1.248-3.531, p = 0.005) was the strongest among them. However, only the p-values for the causal associations of obesity with GrimAge, PhenoAge, and telomere length met the criteria after correction using the Bonferroni multiple test. In the reverse MR analysis, there were statistically significant causal associations between HorvathAge, PhenoAge and GrimAge and BMI, but these associations exhibited lower effect sizes, as indicated by their Odds Ratios (ORs). Notably, sensitivity analysis revealed the robustness of the study results.
CONCLUSIONS: The present findings reveal a causal relationship between obesity and the acceleration of epigenetic aging as well as the reduction of telomere length, offering valuable insights for further scientific investigations aimed at developing strategies to mitigate the aging process in humans.
Asthma affects 20 million people in the United States. It can be caused by many factors, including exposure to tobacco smoke, infections, and other allergens. Recent research suggests that there may be a relationship between obesity and asthma. It is not fully understood how these two conditions are linked, but inflammation may play a role. Obesity-related inflammation may increase the risk of airway inflammation, thereby elevating the risk of developing asthma. Increased inflammation related to obesity may also reduce the effectiveness of inhaled steroid asthma medications, including glucocorticoids. Compared with people of normal weight, people who are overweight or obese may have a higher risk of developing glucocorticoid insensitivity, resulting in intolerance to glucocorticoid medications. The purpose of this study is to examine the effect that obesity has on glucocorticoid insensitivity and inflammation. This study will also examine differences in the response to asthma steroid medications between people who are overweight or obese and those who are not.

This study will use previously collected data from participants in two clinical trials of the NHLBI-funded Asthma Clinical Research Network (ACRN): the Best Adjustment Strategy for Asthma in Long Term (BASALT) study (NCT00495157) and the Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC) study. There will be no additional study visits specifically for this study. Researchers will examine blood samples collected at participants' first BASALT or TALC study visit to analyze levels of inflammation biomarkers (including tumor necrosis factor-alpha \[TNF-α\], interleukin-6 \[IL-6\], and leptin) and proinflammatory cytokines levels, which influence glucocorticoid insensitivity. Additional BASALT and TALC study data, including lung function, asthma symptoms, and asthma exacerbations, will also be analyzed.
Preparation of biological complexes with a specific area of activity by aerobic incubation of a mixture of (a) minced animal or vegetable tissue of the type to be treated by the final product; (b) a nitrogenous nutrient medium and (c) an inoculum of a microorganism, stabilization of the bacterial activity, e.g. with methanol, filtration and optional deodorization. Therapeutic compositions which are specific for certain tissues and which are as active as antibiotics. The activity of the product is improved if the microorganism is made specific for the purpose e.g. by feeding larvae of invertebrates e.g. insects such as the bluebottle, echinoderms or annelid worms with the type of tissue to be treated. Worms are used for vegetable tissue, the others for animal tissue. The liquor from the larval digestive system is used to inoculate the nutrient medium at pH 7 and incubated at 16-20 degrees C. The organism is plated out and then grown on blood/agar plates for 7 days at 18-20 degrees C. The products are active against pathogenic organisms e.g. paratyphus A and B, E.coil, Staph.aureus and Strep.faecium.
Group 2 will be randomized as to which agent they receive for cycle one. Cycles 2 and beyond are treated using both agents.
Cangrelor in up to four (4) dose cohorts consisting of a minimum of five participants in each cohort. One cohort of five participants will be enrolled at a time. Cohort 1 subjects will receive Cangrelor at 0.5 mcg/kg/min. Cohort 2 subjects will receive Cangrelor at 0.25 mcg/kg/min. Subsequent cohort dosing decisions are made at the completion of enrollment in each cohort.
Deep learning-based multi-omics data integration methods have the capability to reveal the mechanisms of cancer development, discover cancer biomarkers and identify pathogenic targets. However, current methods ignore the potential correlations between samples in integrating multi-omics data. In addition, providing accurate biological explanations still poses significant challenges due to the complexity of deep learning models. Therefore, there is an urgent need for a deep learning-based multi-omics integration method to explore the potential correlations between samples and provide model interpretability. Herein, we propose a novel interpretable multi-omics data integration method (DeepKEGG) for cancer recurrence prediction and biomarker discovery. In DeepKEGG, a biological hierarchical module is designed for local connections of neuron nodes and model interpretability based on the biological relationship between genes/miRNAs and pathways. In addition, a pathway self-attention module is constructed to explore the correlation between different samples and generate the potential pathway feature representation for enhancing the prediction performance of the model. Lastly, an attribution-based feature importance calculation method is utilized to discover biomarkers related to cancer recurrence and provide a biological interpretation of the model. Experimental results demonstrate that DeepKEGG outperforms other state-of-the-art methods in 5-fold cross validation. Furthermore, case studies also indicate that DeepKEGG serves as an effective tool for biomarker discovery. The code is available at https://github.com/lanbiolab/DeepKEGG.
A once daily dosage of Insulin detemir (Levemir®) 100 U/mL 3 mL FlexPen® for subcutaneous administration was selected for this trial. During the treatment period insulin detemir was adjusted by the subject themselves (self-titration). Self-titration was performed every 3 days based on the lowest of three previous consecutive pre-breakfast SMPG values.Based on this glucose value, self-adjustment of insulin detemir dose was done. Metformin and Sulfonlylurea were allowed as OADs. For SMPG values , the following insulin detemir dose adjustments were done : \>10.0 mmol/L (180 mg/dL) +8U insulin detemir, 9.1-10.0 mmol/L (163-180 mg/dL) +6U insulin detemir, 8.1-9.0 mmol/L (145-162 mg/dL) +4 U insulin detemir, 7.1-8.0 mmol/L (127-144 mg/dL) +2U insulin detemir, 6.1-7.0 mmol/L (109-126 mg/dL) +2U insulin detemir, 4.1-6.0 mmol/L (73-108 mg/dL) No adjustment in insulin detemir, 3.1-4.0 mmol/L (56-72 mg/dL) -2U insulin detemir, \<3.1 mmol/L (\<56 mg/dL) -4U insulin detemir.
OBJECTIVE: To explore effect of nerve growth factor (NGF) antibody on knee osteoarthritis (KOA) pain model was evaluated by in vitro model.
METHODS: Thirty male SPF rats aged 28-week-old were divided into blank group (10 rats with anesthesia only). The other 20 rats were with monoiodoacetate (MIA) on the right knee joint to establish pain model of OA, and were randomly divided into control group (injected intraperitoneal injection of normal saline) and treatment group (injected anti-NGF) intraperitoneal after successful modeling, and 10 rats in each group. All rats were received retrograde injection of fluorogold (FG) into the right knee joint. Gait was assessed using catwalk gait analysis system before treatment, 1 and 2 weeks after treatment. Three weeks after treatment, right dorsal root ganglia (DRG) were excised on L4-L6 level, immunostained for calcitonin gene-related peptide (CGRP), and the number of DRGS was counted.
RESULTS: In terms of gait analysis using cat track system, duty cycle, swing speed and print area ratio in control and treatment group were significantly reduced compared with blank group (P<0.05). Compared with control group, duty cycle and swing speed of treatment group were significantly improved (P<0.05), and there was no significant difference in print area ratio between treatment group and blank group (P>0.05). The number of FG-labeled DRG neurons in control group was significantly higher than that in treatment group and blank group (P<0.05). The expression of CGRP in control group was up-regulated, and differences were statistically significant compared with treatment group (P<0.05).
CONCLUSION: Intraperitoneal injection of anti-NGF antibody inhibited gait injury and upregulation of CGRP in DRG neurons. The results suggest that anti-nerve growth factor therapy may be of value in treating knee pain. NGF may be an important target for the treatment of knee OA pain.
This study is a multicentre prospective single-arm registry study and the protocol is approved by the ethics committee at the coordinating centre and by the local institutional review board at each participating centre. This study is initiated by the investigators, with 20 participating stroke centres (see online supplementary appendix II), and plans to recruit 300 consecutive patients who meet the inclusion and exclusion criteria. After the enrolment, all participants would be evaluated at baseline, day 4, day 30, months 6, months 9 and year 1 (see online supplementary appendix I). The Wingspan stent system is provided by the Boston Scientific company and the Apollo stent is provided by the MicroPort Company, but they will not participate in data collection, analysis, editing or make decisions about the publication. This study is sponsored and conducted by the Cerebrovascular Disease Center of Tiantan Hospital in addition to its responsibility for data analysis. An independent Data and Safety Monitoring Board (DSMB) oversees the conduction, safety and efficacy of the study.
The invention discloses semen arecae liquor which is prepared through conventional technologies from following components, by weight, 50 parts of semen arecae, 50 parts of cinnamon, 15 parts of codonopsis pilosula, 7 parts of paeony, 10 parts of rose flower, 15 parts of radix glycyrrhizae, 20 parts of rock candy, 5 parts of radix scrophulariae, 10 parts of red dates and 1000 parts of liquor. The components, except the liquor, are placed in a container with addition of the liquor. The container is sealed and the components are soaked in the liquor for 15 days. Filtration is carried out to remove residues to obtain the semen arecae liquor. The semen arecae liquor has effects of soothing liver and releasing depression, and activating blood and regulating menstruation, is mainly used for treating chloasma in qi depression type, is fragrant and mellow in taste and has functions of expelling parasites and fastening teeth, stimulating spirit and waking brain, regulating essence and freeing collaterals, boosting essence and tonifying yang, and moving fluid and expelling qi. The semen arecae liquor is taken orally with a dosage being 10-20ml by two times per day.
The invention provides a chronic disease management method and system based on small sample learning and a large language model, and belongs to the technical field of medical technology and artificial intelligence. The method first divides a patient having a multi-dimensional physiological index into a plurality of subgroups using a small sample learning algorithm. Then, by using a large language model, key information is extracted from text information including medical history, and patient self-description. The two information are combined by a chronic risk assessment function to generate a risk assessment vector containing risk assessments for various chronic diseases. Finally, a multidimensional optimization algorithm is used to generate the optimal personalized treatment plan vector based on the risk assessment vector and the available treatments. The method comprehensively utilizes various data sources and advanced algorithms, and aims to provide a more comprehensive, accurate and personalized chronic disease management scheme.
Interventions done in 30 patients and included intracanal medicament . After biomechanical preparation of root canal, 2%Chlorhexidine gluconate gel as an intracanal medicament was placed in root canal from pulp chamber to apex for 3 months (replacing every month). After 3 months,periodontal surgery in the form of open flap debridement (OFD) was performed in the respective tooth and medicament was changed and placed further for 3 months (replacing every month). Obturation was done after 3 months of OFD.
Analogs related to oleamide are employed for potentiating the 5-HT 2A  and 5-HT 1A  responses to serotonin (5-HT). With respect to the potentiation of the 5-HT 2A  receptor response, it is disclosed that, of the naturally occurring fatty acids, the primary amide of oleic acid (oleamide) is the most effective potentiating agent of serotonin and that the potentiating activity of oleamide analogs is highly dependent upon their structural features. In particular, the presence, position, and stereochemistry of the 9-cis double bond is required and even subtle structural variations reduce or eliminate activity. Secondary or tertiary amides may replace the primary amide but follow a well-defined relationship requiring small amide substituents suggesting that the carboxamide serves as a hydrogen bond acceptor but not donor. Alternative modifications at the carboxamide as well as modifications of the methyl terminus or the hydrocarbon region spanning the carboxamide and double bond typically eliminate activity. With respect to the potentiation of the 5-HT 1A  receptor response, it is disclosed that the potentiation activity of oleamide analogs is more tolerant and accommodates a wider range of structural modifications. One genus of analogs is disclosed that inhibits rather than potentiates the 5-HT 2A , but not the 5-HT 1A , receptor response. Such analogs permit the selective modulation of serotonin receptor subtypes and have opposing effects on the different subtypes.
Impaired testicular function contributes to around 50% of heterosexual infertility and is often characterized by a low total motile sperm count. Evidence suggests that one cause of low total motile sperm count is oxidative stress within the ejaculate, where harmful oxygen species damage the sperm. Antioxidants to combat oxidative stress within the ejaculate have been proposed as a method of increasing the total motile sperm count. Lycopene is a powerful antioxidant found abundantly in cooked tomatoes and has been shown to improve testicular function in a healthy population. This double blinded randomised controlled trial aims to investigate whether lycopene can improve testicular output in participants with a low motile sperm count. Semen analysis will be carried out before and after the intervention. The intervention is a commercially available lycopene capsule or an identical placebo.

Hypothesis: Supplementation with lactolycopene will improve testicular function (semen quality) in males with low total motile sperm count (TMSC).
The invention discloses an orally-taken traditional Chinese medicine preparation for treating fracture and belongs to the field of traditional Chinese medicines. The invention is characterized in that the preparation is prepared from the following crude drugs in weight: 3-12g of vermiculite, 10-20g of hydration muscovite, 3-9g of native copper, 8-15g of red halloysite, 3-10g of white dragon bone, 0.5-3g of Acacia catechu, 0.01-0.1g of realgar, 3-15g of myrrh, 3-15g of frankincense, 0.5-3g of sangusis draconis and 0.01-0.1g of musk. Firstly, impurities in the crude drugs are removed; the crude drugs are respectively crushed into a powder; the powders are encapsulated after being evenly mixed. The preparation is taken after being mixed with yellow wine or plain boiled water. The preparation is taken two times a day, 3g each time and once in the morning and once in the evening after the meal for continuous three days. After three days, the preparation is taken one time a day and 3g each time in the evening after the meal for continuous four days, and a course of treatment contains seven days. The orally-taken traditional Chinese medicine preparation is obvious in clinical effects of promoting circulation and removing stasis, dispersing swelling and promoting granulation, stopping pain and promoting granulation and treating traumatic injuries, traumatic swelling and pain and fractured muscles and bones. Hundreds of patients are cured, and the effective rate is 81 percent.
The invention provides a ginkgo leaf capsule. The ginkgo leaf capsule comprises, by weight, 30 to 50 parts of a ginkgo leaf extract, 120 to 180 parts of beta-cyclodextrin, 7 to 12 parts of talcum powder and 0.5 to 1.5 parts of magnesium stearate. A granule is prepared from the above-mentioned raw materials and then fills a hard capsule shell so as to prepare the ginkgo leaf capsule. The ginkgo leaf capsule prepared in the invention has more stable performance and a better clinical curative effect. The invention further provides a preparation method for the ginkgo leaf capsule. The method comprises the following steps: preparing spraying slurry from beta-cyclodextrin and ethanol; subjecting the raw materials to one-step drying and granulation by using a fluid bed granulating and drying machine; and filling the obtained granule to prepare the capsule. The method can overcome disadvantages of the prior art and substantially improves bioavailability, solubility and chemical and physical stability of a drug.
1283085 Acylating antibiotic T-2636C TAKEDA YAKUHIN KOGYO KK 24 Oct 1969 [26 Oct 1968] 52130/69 Heading C2A Novel 8- or 14-monoacyl and 8,14-diacyl derivatives of the antibiotic T-2636C, having the formula in which Ac is an acyl group of formula R-CO- where R is H; C 1  to C 5  alkyl or C 2  to C 5  alkenyl, each of which may be substituted by carboxyl or halogen; or is C 6  to C 9  aryl; pyridyl; or C 7  to C 10  aralkyl optionally substituted by halogen, are prepared by reacting the antibiotic T-2636C with one or two mols. of an appropriate acylating agent or agents and if required partially hydrolysing the diacyl derivative to remove one of the acyl groups. The acylation may be performed in two stages with differing acylating agents to give different groups Ac in the 8 and 14 positions. The acylation is carried out preferably in an inert solvent in the presence of a condensing agent such as trifluoracetic acid anhydride. The carboxylic acid, its halide or anhydride may be used as acylating agent. When a mixture of the 8- and 14-monoacyl derivatives are formed, they may be separated chromatographically. Partial hydrolysis of the diacyl derivative may be effected with an aqueous acid or alkali, or by adsorbing the derivative on a suitable adsorbent (e.g. silica gel or alumina) and exposing it to moist air, or by hydrolysis with enzymes of the T-2636C- producing micro-organism Streptomyces rochei var. volubilis. For this procedure the whole culture, a culture filtrate, a crude enzyme preparation or an acetone-powder of the mycelium of the micro-organism are used as the hydrolysing agent. The acyl derivatives of T-2636C have improved antibiotic activity against Grampositive bacteria.
PURPOSE: Acute myocardial infarction (AMI) and stroke are leading global causes of death and can be used to assess acute care quality. We examined the 30-day mortality trends after emergency department admission for AMI and stroke in Korea from 2008 to 2019, focusing on regional and income disparities.
MATERIALS AND METHODS: The AMI and stroke patients admitted to hospitals in Korea were collected from the claims data. We analyzed age and sex-standardized 30-day mortality for AMI, as well as hemorrhagic and ischemic strokes. Disparities in mortality were analyzed using absolute differences and relative ratios between the Organization for Economic Cooperation Development (OECD) and Korea, and among income levels and regions in Korea. A 12-year joinpoint regression was used to determine the annual percent change and the average annual percent change.
RESULTS: The trends in the 30-day AMI mortality of Korea were not significantly changed from 2008 to 2019; the gap remained at 1.2 between the OECD and Korea. Korea maintained lower mortality rates for hemorrhagic and ischemic stroke than the mean of OECD. In Korea, the 30-day hemorrhagic stroke mortality showed a constant decreasing trend for the higher-income group living in urban areas; it led to a widened gap based on income levels in urban areas. The 30-day mortality for ischemic stroke tended to decrease in the higher-income group and urban areas.
CONCLUSION: National-level intervention is needed to manage regional and income-based disparities in AMI and stroke 30-day mortality. It is important to understand the variance in mortality rate by different geographical regions and income levels to establish an appropriate public health strategy.