anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Methods and systems for providing a telepresence to a remote user are disclosed. A data connection between a headgear device in a first location and a display device in a second location is established. A first input device communicatively coupled to the headgear device collects at least one of first video data and first audio data. At least one of the first video data and the first audio data is transmitted to the display device. At least one of the first video data and the first audio data is output on the display device. In response to outputting at least one of the first video data and the first audio data, at least one of haptic data and second audio data is collected by at least a second input device. The at least one of the haptic data and the second audio data is transmitted to the headgear device.
Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least one cytokine that regulates development of a T helper type 1 or T helper type 2 response is modulated. In one embodiment, the agent is a stimulatory form of a compound comprising a Lewis antigen, such as a Lewis y , Lewis x  or Lewis a  oligosaccharide, or a derivative thereof. In another embodiment, the agent is an inhibitory form of a compound comprising a Lewis antigen, such as a Lewis y , Lewis x  or Lewis a  oligosaccharide, or a derivative thereof. In various embodiments, the immune cell is a human immune cell, a macrophage or a T cell. Pharmaceutical compositions for modulating immune responses are also provided.
Metronidazole has shown evidence of carcinogenic activity in a number of studies involving chronic oral administration in mice and rats. Pulmonary tumors were reported in several mouse studies in which mice were dosed orally at 75 mg/kg and above (about 6 or more times the maximum recommended human dose based on mg/m 2). Malignant lymphoma was reported at 66 mg/kg and above (about 5 or more times the maximum recommended human dose based on mg/m 2). These tumors have been observed in all six reported studies in the mouse, including one study in which the animals were dosed on an intermittent schedule (administration during every fourth week only). All these effects were statistically significant. 

There were statistically significant increases in the incidence of mammary tumors, among female rats administered metronidazole at 270 mg/kg and above (about 40 times the maximum human dose based on mg/m 2). Hepatic adenomas and carcinomas were observed in rats administered 300 mg/kg (about 45 times the maximum human dose based on mg/m 2). 

Two lifetime oral tumorigenicity studies in hamsters have been performed and reported to be negative at doses up to 80 mg/kg (about 10 times the maximum human dose based on mg/m 2). 

Carcinogenesis studies have not been conducted with NUVESSA.

Although metronidazole has shown in vitro mutagenic activity in bacterial reverse mutation tests, it was negative in in vitro mammalian mutation systems including CHO/HGPRT and CH V79 lung cell assays. Metronidazole was not clastogenic in vitro chromosome aberration tests in CHO cells up to 5000 µg/mL but was positive in human and monkey peripheral blood lymphocytes at 0.1 µg/mL. 

In general, numerous micronucleus studies in rats and mice have failed to demonstrate a potential for genetic damage up to single oral doses 3000 mg/kg in mice (about 225 times the maximum human dose based on mg/m 2). However, a dose dependent increase in the frequency of micronuclei was observed in CFW mice after intraperitoneal injections of up to 160 mg/kg (about 12 times the maximum human dose based on mg/m 2). 

Fertility studies have been performed in mice orally dosed up to 500 mg/kg (about 37 times the maximum human dose based on mg/m 2) revealed no evidence of impaired fertility. 

While no effects on fertility were observed in female rats dosed intraperitoneally at doses up to 1000 mg/kg (about 300 times the maximum human dose based on mg/m 2), studies in male rats resulted in effects on testes and sperm production at oral doses of 100 mg/kg and above (about 30 times the maximum human dose based on mg/m 2).
BACKGROUND: In standard colonoscopic examinations, some polyps may be missed during the withdrawal phase. Re-examination of the right colon can improve the adenoma detection rate (ADR). However, the effectiveness of applying this re-examination strategy to the entire colon remains unknown. We investigated whether re-examination could increase the detection rate of polyps and adenomas throughout the colon.
METHODS: A randomized, controlled, single-center trial (NCT03268200) was conducted in a university hospital. Patients aged 45-75 years were randomly assigned to either the study or control group. For patients in the control group, observation and polypectomy were performed once using the standard colonoscopy method. For patients in the study group, polypectomy was repeated twice during the withdrawal phase after the initial insertion of the colonoscope. These examinations were performed in the right transverse and left colons. The primary endpoints were the polyp detection rate (PDR) and ADR, defined as the proportion of patients with ≥ 1 polyp and ≥ 1 adenoma, respectively.
RESULTS: Overall, 406 patients were enrolled (study group, n = 210; control group, n = 196) and analyzed. Generally, PDRs and ADRs were similar between the study (withdrawal 1 + 2) and control groups (withdrawal 1), except for the right colon. However, the second withdrawal review increased number of polyps and adenomas in the overall, right, mid, and left colon, respectively.
CONCLUSION: The results of this trial indicated that re-examination of the entire colon during colonoscopy could be beneficial for detecting concealed polyps in patients at risk of interval cancer.
INTRODUCTION: Urinary incontinence (UI) affects over half of people with stroke. It is unclear which methods are accurate in assessing presence and type of UI to inform clinical management. Diagnosis of UI based on inaccurate methods may lead to unnecessary interventions. The aims of this systematic review were to identify, for adults with stroke, clinically accurate methods to determine the presence of UI and type of UI.
METHOD: We searched seven electronic databases and additional conference proceedings. To be included, studies had to be primary research comparing two or more methods, or use a reference test.
RESULTS: We identified 3846 studies with eight eligible for inclusion. We identified 11 assessment methods within the eight studies. Only five studies had sufficient comparator data for synthesis. Due to heterogeneity of data, results on the following methods were narratively synthesized: Core Lower Urinary Tract Symptom Score (CLSS), clinical history and physical examination, Barthel Activities of Daily Living Index, International Consultation Incontinence Questionnaire Short Form (ICiQ-SF) and urodynamic studies (UDS). Most studies were small and of low to medium quality. All reported differences in sensitivity, and none compared the same assessment methods.
CONCLUSION: Current evidence is insufficient to support recommendations on the most accurate UI assessment for adults with stroke. Further research is needed.
Although coronary angiography is widely used in the diagnosis and evaluation of CAD and heart valve diseases, it causes patients to experience intense stress, anxiety, pain and even fear of death. The main purpose of nurses before an interventional procedure is to increase the physiological and mental well-being of the patient and to help them adapt to the procedure. Various pharmacological and non-pharmacological methods are used to manage the psychological and physical problems of patients undergoing coronary angiography. Distraction is one of the non-pharmacological interventions commonly used during medical procedures. Virtual reality (VR) is a new method that can be used to distract and prepare patients for the procedure during medical procedures. It is thought to be more effective than traditional methods. Virtual reality is a computer-generated environment in which three-dimensional interaction is possible. It projects a wide field of view in front of the user's eye through advanced head-worn screens (glasses). It is an advanced technology that allows the individual to move into a virtual environment and focus his attention on other thoughts to less consideration for pain and anxiety.

This study is a randomized controlled study to determine the effectiveness of virtual reality glasses on pain, anxiety and hemodynamic parameters during coronary angiography.The universe of the study will be the individuals who will have a coronary angiography in the Angiography Laboratory of the Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital. On the other hand, the sample of the study will consist of patients who meet the inclusion criteria within the time the study is planned. Power analysis was performed using the G \* Power (v3.1.7) program to determine the number of samples. It was decided that there should be at least 64 people in the groups. Participants in the study will be randomly divided into two groups as intervention and control groups. Before the procedure, patients will be informed about the purpose of the study, and written and verbal informed consent will be obtained from the patients. Patients in both groups will be asked to fill in the Personal Information Form before the procedure, and their pain levels will be evaluated with the Visual Analogue Scale (VAS), and their anxiety levels will be evaluated with the State-Trait Anxiety Inventory I (STAI-I). Immediately after the procedure, the pain levels of the patients with VAS and their anxiety levels will be evaluated with STAI-I. Virtual reality glasses will be worn on the intervention group just before the procedure starts and patients will continue to wear VR glasses until the procedure is completed. In patients selected as the control group, the same evaluations will be made at the same time interval. SPSS 22.0 (Statistical Package of Social Sciences) package program will be used for statistical analysis.
Participants will receive a placebo beetroot juice with the nitrate removed, by Beet It, James White. Participants will take 1 placebo juice drink everyday for 12 weeks.
Primary open angle glaucoma subjects as well as pre-perimetric glaucoma suspects will be classified by clinical exam by an experienced glaucoma specialist according to the American Academy of Ophthalmology Practice Patterns. Glaucoma subjects and suspects will undergo adaptive optics (AO) imaging of several macular locations. A subset of subjects will undergo oxygen challenge intervention, which involves breathing 100% oxygen through a mask during AO imaging at pre-determined retinal vessel locations.
Participants in the waitlist control group will wait for 6 weeks without the CBT-I intervention and then complete the post-intervention assessment; while waiting for 4 more weeks and then completing the follow-up assessment. The waitlist control participants will start CBT-I (equivalent to that of the CBT-I group) immediately after completing the follow-up assessment.
FIELD: veterinary science, veterinary gynecology. SUBSTANCE: method deals with treatment of early endometritis detected in cows on 6th-12th day after calving. Therapy is conducted by intrauterine sanation with 0.3-% desaxone water solution at the dose of 50-200 ml simultaneously with intramuscular injection of prostaglandin F2-alpha at the dose of 2-3 ml per a cow, and endometritis detected on 15th-25th day after calving - due to intrauterine sanation with 0.3-0.5-% desaxone water solution at the same dose (50-200 ml) simultaneously with intramuscular injection of 2-3 ml of 2-% synestrol solution. Treatment should be carried out thrice not more at an interval of 72 h. Desaxone solution should be introduced for cows with the help of uterine catheter connected with a Janet's syringe. EFFECT: higher efficiency to be used on cows at cattle farms and large-scale farm complexes, to decrease therapy course and improve infertility level in cows. 1 tbl
A remotely supervised resistance exercise program will be carried out for 8 weeks, with three weekly sessions lasting approximately 60 minutes each. Training will be performed in groups of four patients, according to their lung function/physical fitness. The first training session will be on site (University) for familiarization, planning and adjustment of the exercises, and the following sessions will be performed online. Each session is divided into: (i) Warm-up and joint mobility; (ii) main part: strength exercises for different muscle groups; and (iii) cool down: stretching and breathing exercises.
A translation scheme translates DICOM content into a format compatible for storage in an NDMA relational database. The translation scheme employs a schema for indexing the DICOM content, and employs a mechanism for translating queries embedded in XML into SQL. The translation scheme translates DICOM  compatible data into a tab delimited flat representation of the DICOM content.  The flat representation is then translated into data compatible with a relational database format, such as SQL, and then into database insert commands. The schema enables capture of the DICOM information into relational tables. Methods are also provided to service XML formatted research and clinical queries, to translate XML queries to optimized SQL and to return query results to XML specified destinations with record de-identification where required. Methods are also provided to interface to NDMA WallPlugs, secured query devices, or GRID devices.
Under ultrasound guidance the continuous thoracic intervertebral foramen block, will be provided to achieve analgesia in polytraumatic patients with rib fractures. A set for continuous peripheral nerve block will be used. The infusion rate of analgesic solution (levobupivacaine 0.25% combined with dexamethasone 16 mg) will be titrated to patient perceived pain.
Three days before their scheduled appointment, participants will receive a message inviting them to watch a 2-minute wellness video and answer some related questions, as well as encouragement to get the flu shot. In this condition, the video will contain basic information about getting the flu. Participants will also receive a reminder message the day before the appointment.
PURPOSE: To investigate the association of mammographic breast density with treatment and survival outcomes in patients with triple-negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NAC).
METHODS: This retrospective study evaluated 306 women with TNBC who underwent NAC followed by surgery between 2010 and 2019. The baseline density and the density changes after NAC were evaluated. Qualitative breast density (a-d) was evaluated using the Breast Imaging Reporting and Data System. Quantitative breast density (%) was evaluated using fully automated software (the Laboratory for Individualized Breast Radiodensity Assessment) in the contralateral breast. Multivariable logistic regression analysis was used to evaluate the association between breast density and pathologic complete response (pCR), stratified by menopausal status. Cox proportional hazard regression analysis was used to evaluate the association among breast density, the development of contralateral breast cancer, and the development of locoregional recurrence and/or distant metastasis.
RESULTS: Contralateral density reduction ≥10 % was independently associated with pCR in premenopausal women (odds ratio [OR], 2.5; p = 0.022) but not in postmenopausal women (OR, 0.9; p = 0.823). During a mean follow-up of 65 months, 10 (3 %) women developed contralateral breast cancer, and 68 (22 %) women developed locoregional recurrences and/or distant metastases. Contralateral density reduction ≥10 % showed no association with the occurrence of contralateral breast cancer (hazard ratio [HR], 3.1; p = 0.308) or with locoregional recurrence and/or distant metastasis (HR, 1.1; p = 0.794).
CONCLUSION: In premenopausal women, a contralateral breast density reduction of ≥10 % after NAC was independently associated with pCR, although it did not translate into improved outcomes.
Participants will be implanted with bilateral STN DBS using PINS 106RS system. DBS stimulation will be initiated one month post surgery. Follow-up visits will be conducted 1/3/6/9/12/15 months post surgery with clinical evaluation, STN LFP recording and resting state functional MRI testing. During the 6-15 month's visit, short-term closed-loop DBS modulation (from 24hours to 72hours ) will be conducted to test the safety and efficacy of closed-loop DBS therapy.
The rubber sheet (13) over its complete under side is adhered to the roller basic body (8). An abutment line (17) is formed between the commencement (14) and end (16) of the rubber sheet (13) and runs at an angle greater than 0 degrees and equal to/smaller than 6 degrees to an axis-parallel line on the upper surface (12) of the roller basic body (8). The rubber sheet can be self-adhesive or applied to a roller basic body provided with adhesive. It is cover-shaped in its application to the surface of the roller basic body. The commencement and end of the rubber body locate on one another in blunt abutment. For application of the rubber lining an adjustable carrier (23) is provided on the surface of the roller basic body. -
Aim: Exploring prescribing trends and economic burden of chronic low back pain (cLBP) patients prescribed buprenorphine buccal film (Belbuca®) or transdermal patches. Methods: In the MarketScan® commercial insurance claims (employees and their spouses/dependents, 2018-2021), the first film or patch prescription date was an index event. The observation covered 6-month pre-index and 12-month post-index periods. Results: Patients were propensity-score matched (708 per cohort). Buprenorphine initiation had stable cost trends in buccal film and increasing trends in transdermal patch cohort. Between-cohort comparisons of healthcare expenditures, cost trends and resource utilization showed significant differences, mostly in favor of buccal film. Buccal film also had higher daily doses and wider dosing range. Conclusion: Buprenorphine film is more cost-effective cLBP treatment with more flexible dosing.
INTRODUCTION: Rib fractures commonly occur in trauma patients with varying presentations. Though the literature in recent years has moved toward favoring more early intervention of acute rib fractures, little has been reported on the matter of surgical fixation for symptomatic rib fracture nonunions.
MATERIALS AND METHODS: We performed a review of PubMed and Cochrane databases for articles published since 2000. Inclusion criteria were studies with greater than six months of follow-up, while case studies were excluded. A thorough analysis was performed on patient outcomes, complications reported, operative techniques utilized, and fixation systems used, among other parameters reported by the articles.
RESULTS: One hundred and thirty-nine studies resulted from our review, and a total of nine studies met our inclusion criteria with a combined total of 182 patients who underwent open reduction and internal fixation for symptomatic rib fracture nonunions. All studies reported a significant reduction of pain with increased satisfaction in the majority of patients. There were a total of 71 postoperative complications, the most common of which included surgical site infections, hardware failure, and hematoma. The most serious complications were insulting injury to the lung parenchyma or pleura; however, these were extremely rare based off the current literature. The use of bone grafting was common with eight of the nine studies mentioning the benefits of grafting.
CONCLUSION: Surgical stabilization of rib fracture nonunions appears to be an appropriate treatment alternative, and various techniques and approaches may be used with similar success. Further studies with higher level of evidence are recommended on the subject.
The delivery devices (20) described herein are capable of delivering one or more active substances by osmotic pumping through preformed passageways (26, 27). An osmotic device according to the invention includes a first osmotic device enclosed within a second osmotic device. The first osmotic device includes drug- containing core (25) surrounded by a first semipermeable membrane (24). The second osmotic device includes a drug-containing composition (23) surrounding the first semipermeable membrane and a second semipermeable membrane (22) surrounding the drug-containing composition. The device can also include an external drug-containing composition (21). In some embodiments, the semipermeable membrane of one or both of the osmotic de-vices completely dissolves or degrades during use. This delivery device can include an immediate release outer coat.
The invention provides a Chinese herb preparation for treating infectious canine hepatitis. The Chinese herb preparation comprises the following Chinese herb raw materials in parts by weight: 15 to 25 parts of felwort, 15 to 20 parts of umbellate pore fungus, 16 to 24 parts of chrysanthemum, 8 to 17 parts of dandelion, 10 to 28 parts of rhizoma atractylodis, 10 to 20 parts of caulis clematidis armandii, 8 to 20 parts of isatis root, 20 to 40 parts of liquorice, 10 to 30 parts of concha haliotidis and 5 to 10 parts of tribulusterrestris. The Chinese herb preparation is reasonable in formula, simple to prepare, extracted from traditional Chinese herbs, low in cost, wide in raw material source and remarkable in curative effect. According to the traditional Chinese veterinarian theory, the preferable material has functions of detoxifying, soothening the liver and nourishing the gall bladder. The pure Chinese herb oral liquid is extracted according to a preferable ratio. The Chinese herb preparation is proved in clinical application that the effect of treating the infectious canine hepatitis is remarkable, and the curative rate can reach 96 percent.