anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine. ^ SUBSTANCE: invention relates to field of nanotechnology and is connected with methods of obtaining, stabilisation and application of highly dispersive lyophobic systems, for instance metal hydrosols, and can be used for imparting antimicrobial properties to wide spectrum of fibre-mesh materials, used in production of clothes and footwear. Composition, based on silver hydrosol for imparting antimicrobial properties to wide spectrum of fibre-mesh materials, contains as stabilising agent copolymer of acrylic acid or acryl amide with different initial ratio of monomers, which has technical name "Polynap", colloidal metallic silver, boric acid, sodium nitrate, borax and water with definite component ratio (wt %). Hydrosol has kinetic and aggregative stability. Composition is not toxic, is stored at room temperature in non-transparent reservoirs for more than 6 months without changes. ^ EFFECT: invention ensures antimicrobial properties of tissue during wet-heat treatment. ^ 1 ex
The hepatocytes within the liver present an immense capacity to adapt to changes in nutrient availability. Here, by using high resolution volume electron microscopy, we map how hepatic subcellular spatial organization is regulated during nutritional fluctuations and as a function of liver zonation. We identify that fasting leads to remodeling of endoplasmic reticulum (ER) architecture in hepatocytes, characterized by the induction of single rough ER sheet around the mitochondria, which becomes larger and flatter. These alterations are enriched in periportal and mid-lobular hepatocytes but not in pericentral hepatocytes. Gain- and loss-of-function in vivo models demonstrate that the Ribosome receptor binding protein1 (RRBP1) is required to enable fasting-induced ER sheet-mitochondria interactions and to regulate hepatic fatty acid oxidation. Endogenous RRBP1 is enriched around periportal and mid-lobular regions of the liver. In obesity, ER-mitochondria interactions are distinct and fasting fails to induce rough ER sheet-mitochondrion interactions. These findings illustrate the importance of a regulated molecular architecture for hepatocyte metabolic flexibility.
PROBLEM TO BE SOLVED: To obtain the subject inhibitor useful as a preventive and therapeutic agent for diseases in which promotion of apoptosis concern, e.g. viral diseases, neurodegenerative diseases, myelodysplastic diseases, isthemic cardiopathy or liver disease by including a specific compound. SOLUTION: This inhibitor is obtained by including a compound of the formula  R is a (substituted)hydrocarbon or a heterocyclic ring; Y is a group of the formula CO, CH(OH) or NR<3> [R<3> is a (substituted)alkyl]; (m) is 0 or 1; (n) is 0-2; X is CH or N; A is a direct bond or a 1-7C divalent aliphatic hydrocarbon; Q is O or S; R<1> is H or an alkyl; ring E is 1 to 4 substituent groups; L and M are each H or a direct bond} or its salt. The compound of the formula has insulin-sensitive enhancing action. The inhibitor contains preferably pioglitazone or its salt, troglitazone or its salt or rosiglitazone or its salt. The dose of the inhibitor is preferably 2-20 mg/kg as the compound of the formula.
Imatinib p.o. 340 mg/m2 given daily from day 15 or 30 (depending on age) to the end of therapy (week 106) in addition to Standard IR-high chemotherapy.
FIELD: biotechnology, veterinary medicine, immunology.SUBSTANCE: a method for obtaining an erythrocyte diagnosticum for the reaction of indirect hemagglutination (IHAR) in animal clostridiosis is proposed, including sensitization of sheep erythrocytes containing formalin and tannin with a mixture of anatoxins of five Cl strains. perfringens No. 28 (type A), LD-1 (type B), No. 392 (type C), No. 213 (type D), No. 342 (type E) in equal proportions obtained from the culture medium by precipitation of formalin-inactivated toxins at a temperature of 37°С (anatoxins) with ammonium sulfate, and somatic antigens obtained by exposure to these Cl. perfringens strains with ultrasound on a disintegrator at a frequency of 20 kHz±500 Hz for 10 min at a temperature of 4°С.EFFECT: provides an increase in the specificity and sensitivity of methods for laboratory diagnostics of anaerobic enterotoxemia (clostridiosis) of unvaccinated livestock of farm animals and control of the intensity of post-vaccination immunity in vaccinated animals.1 cl, 2 tbl, 6 ex
Barbiturates are absorbed in varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids.

The onset of action for oral or rectal administration varies from 20 to 60 minutes. For IM administration, the onset of action is slightly faster. Following IV administration, the onset of action ranges from almost immediately for Pentobarbital Sodium to 5 minutes for phenobarbital sodium. Maximal CNS depression may not occur until 15 minutes or more after IV administration for phenobarbital sodium.

Duration of action, which is related to the rate at which the barbiturates are redistributed throughout the body, varies among persons and in the same person from time to time.

No studies have demonstrated that the different routes of administration are equivalent with respect to bioavailability.

Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids with high concentrations in the brain, liver, and kidneys. Lipid solubility of the barbiturates is the dominant factor in their distribution within the body. The more lipid soluble the barbiturate, the more rapidly it penetrates all tissues of the body. Barbiturates are bound to plasma and tissue proteins to a varying degree with the degree of binding increasing directly as a function of lipid solubility.

Phenobarbital has the lowest lipid solubility, lowest plasma binding, lowest brain protein binding, the longest delay in onset of activity, and the longest duration of action. At the opposite extreme is secobarbital which has the highest lipid solubility, plasma protein binding, brain protein binding, the shortest delay in onset of activity, and the shortest duration of action. Butabarbital is classified as an intermediate barbiturate.

The plasma half-life for pentobarbital in adults is 15 to 50 hours and appears to be dose dependent.

Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine, and less commonly, in the feces. Approximately 25 to 50 percent of a dose of aprobarbital or phenobarbital is eliminated unchanged in the urine, whereas the amount of other barbiturates excreted unchanged in the urine is negligible. The excretion of unmetabolized barbiturate is one feature that distinguishes the long-acting category from those belonging to other categories which are almost entirely metabolized. The inactive metabolites of the barbiturates are excreted as conjugates of glucuronic acid.
The invention relates to medicine, namely to the clinical immunology. Summary of the invention consists in the fact that the active substances are extracted in the boiling process from the vegetal therapeutic raw material, which includes in mass %: the milfoil grass (Achillea millefolium) 5...15, the pot marigold flowers (Calendula officinalis) 5...15, the stinging nettle leaves (Urtica dioica) - the rest, having the vegetal therapeutic raw material ratio: water 1 : 50. The boiling is carried out during 2...3 min, then the obtained extract is cooled up to 35...37 C and it is filtered. The filtrate is diluted with distilled water 1 : 10 respectively, it is filtered through kaolin, it is supplementary filtered and sterilized. The result consists in obtaining a remedy modulating the macrophage activity and proliferation of B- and T-lymphocytes. Claims: 3
BACKGROUND AND OBJECTIVE: The utility of prostate radiotherapy (RT) is unclear in men with metastatic hormone-sensitive prostate cancer (mHSPC) receiving intensified systemic therapy with androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPIs). We performed a network meta-analysis of randomized controlled trials (RCTs) to investigate the role of prostate RT in low-volume mHSPC.
METHODS: Bibliographic databases and conference proceedings were searched through July 2023 for RCTs evaluating the addition of ARPIs or prostate RT to standard of care (SOC) systemic therapy, defined as ADT or ADT plus docetaxel, for the initial treatment of mHSPC. We focused exclusively on aggregate data from the low-volume mHSPC subpopulation in these trials. We pooled the treatment arms into four groups: SOC, SOC plus ARPI, SOC plus RT, and SOC plus ARPI plus RT. The primary outcome was overall survival (OS). To compare treatment strategies, a fixed-effects Bayesian network meta-analysis was undertaken, while a Bayesian network meta-regression was performed to account for across-trial differences in docetaxel use as part of SOC and in proportions of patients with de novo presentation.
KEY FINDINGS AND LIMITATIONS: Ten RCTs comprising 4423 patients were eligible. The Surface Under the Cumulative Ranking Curve scores were 0.0006, 0.45, 0.62, and 0.94 for SOC, SOC plus RT, SOC plus ARPI, and SOC plus ARPI plus RT, respectively. On a meta-regression, in a population with de novo mHSPC and no docetaxel use, we did not find sufficient evidence of a difference in OS between SOC plus ARPI plus RT versus SOC plus ARPI (hazard ratio [HR]: 0.76; 95% credible interval: 0.51-1.16) and SOC plus RT versus SOC plus ARPI (HR: 1.10; 95% credible interval: 0.92-1.42).
CONCLUSIONS AND CLINICAL IMPLICATIONS: There was some evidence that SOC plus ARPI plus RT reduced mortality compared with the next best strategy of SOC plus ARPI in patients with low-volume de novo mHSPC. A meta-analysis with individual patient data or an RCT is needed to confirm these findings.
This study will prospectively assess clinical outcomes in health-related quality of life (HRQOL) in men undergoing open, or robotic-assisted laparoscopic radical prostatectomy. Open radical prostatectomy is a frequently performed treatment for patients with clinically localized (cT1-T2) prostate cancer. The open technique stands as a benchmark against which all other treatments, including new surgical techniques, must be compared. Robotic-assisted and laparoscopic radical prostatectomy is considered an alternative surgical option for clinically localized prostate cancer. While this minimally invasive technique is more frequently being performed in the United States, a detailed comparison of the open and robotic-assisted laparoscopic techniques has not been performed. The relative risks and benefits of these surgical treatment options have not been explored in a contemporary group of patients treated at the same center by surgeons experienced in the open and robotic-assisted laparoscopic techniques. This study will address this deficiency in that follow-up information will be collected prospectively in consecutive patients undergoing open or robotic-assisted laparoscopic radical prostatectomy. While a prospective, randomized trial might be considered a more appropriate methodology to conduct such a comparative study, we have no baseline information, no guidelines to assess robotic-assisted laparoscopic competence, and a lack of skilled robotic-assisted laparoscopic pelvic surgeons to justify a lengthy and expensive trial. We will also collect information on health service utilization and employment during the 12-month postoperative period in order to assess the economic impacts of the different surgical approaches. While results from our proposed study will not necessarily be generalizable to all surgeons and may very well be a comparison of surgeons rather than techniques, the results will provide an initial assessment comparing experts in the open and robotic-assisted laparoscopic techniques. To date, no such comparison has been published. To our knowledge, no other center has expert surgeons in these techniques where such a study would be feasible. Because open techniques have improved dramatically over the past several years, and because the baseline data to be recorded in this proposal is not currently collected, use of historical controls for open radical prostatectomy would be inappropriate.
INTRODUCTION: Biotinidase deficiency (BD) is an inherited autosomal recessive metabolic disorder. BD has been associated with optic nerve atrophy, eye infections, and retinopathy. The most prevalent ophthalmic manifestation of BD is optic atrophy, which might be misdiagnosed as multiple sclerosis or neuromyelitis optica, especially in late-onset BD cases.
METHODS: In this article, we report a 9-year-old boy with gradual vision loss. Ophthalmologic examination, Brain MRI, and several laboratory tests such as Aquaporin-4 IgG level and biotinidase level were done on the patient.
RESULTS: Bilateral optic atrophy and impaired visual acuity were detected on examination. The patient had a biotin level of 1.25 U/min/ml (normal range 3-9 U/min/ml), favoring the BD.
CONCLUSION: In this study, we report a 9-year-old boy with vision loss diagnosed with BD. We also reviewed the literature to highlight the ophthalmic manifestations of BD. Ophthalmologists must consider BD in children with unexplained ophthalmologic complaints, especially when other characteristic signs of BD (e.g., developmental delay, seizure) are present. Also, patients with BD should undergo regular annual ophthalmologic examinations to be checked for any signs of eye involvement.
The invention discloses application of polypeptide specific-binding TRB3 in treating or preventing abdominal aortic aneurysm. The amino acid sequence of the polypeptide is showed as SEQ ID NO:1. The polypeptide derivative is a chimeric peptide formed by the polypeptide connecting with a cell penetrating peptide or a dosage form formed by the polypeptide coordinated with a drug excipient. The polypeptide is screened by the surface plasma resonance (Biacore) method, and can specifically bind to TRB3 and blockade the combination of TRB3 and P62 protein. Meanwhile, the polypeptide derivative Pep2-A2 can treat the mice abdominal aortic aneurysm by knocking-out ApoE inducted by angiotensin II. Thus, the polypeptide and the polypeptide derivative can be used as a novel inhibitor for TRB3, and can be used in exploiting vaccine or medicament for inhibiting abdominal aortic aneurysm.
The invention relates to the technical field of ear care for animals, in particular to cat ear care water containing a traditional Chinese medicine composition and a preparation method thereof. The Chinese medicinal composition comprises four Chinese medicinal materials of Polygonatum kingianum, Daphne odora, Combretum bretaceae and Hibiscus syriacus. The traditional Chinese medicine composition and the anti-inflammatory agent form a main part and an auxiliary part, and have the synergistic effect. The traditional Chinese medicine composition has the main effects of expelling parasites and relieving itching, dispelling wind and removing dampness, and activating collaterals and relieving pain, and the anti-inflammatory agent is the messenger thereof, and is specifically characterized in that the anti-inflammatory agent can strengthen dredging and drug efficacy permeation, so that the drug effect is strengthened, and the time effect is shortened. The anti-inflammatory agent buffers the irritating effects of the surfactant on the affected parts of the cat. The cat ear mite care product prepared by the preparation method has the characteristics of good curative effect, quick response, small toxic and side effect, low drug resistance and wide application range, and is simple in process, low in production cost and suitable for industrial production.
LYRICA CR should be administered once daily after an evening meal.

LYRICA CR should be swallowed whole and should not be split, crushed, or chewed.

When discontinuing LYRICA CR, taper gradually over a minimum of 1 week.

Instruct patients that if they miss taking their dose of LYRICA CR after an evening meal, then they should take their usual dose of LYRICA CR prior to bedtime following a snack. If they miss taking the dose of LYRICA CR prior to bedtime, then they should take their usual dose of LYRICA CR following a morning meal. If they miss taking the dose of LYRICA CR following the morning meal, then they should take their usual dose of LYRICA CR at the usual time that evening following an evening meal [see Patient Counseling Information (17)].
BACKGROUND: The prevalence of possible sarcopenia is notably high among maintenance hemodialysis (MHD) patients. Possible sarcopenia, defined as a decrease in muscle strength and/or somatic function, is an early and reversible condition between non-sarcopenic and sarcopenia, and early recognition and intervention for possible sarcopenia is important for preventing adverse outcomes and improving the quality of life of these patients. This study aimed to establish a simple and effective model for screening and identifying MHD patients at high risk of possible sarcopenia by using 50 kHz-Whole Body Phase Angle (PhA), with a specific focus on gender differences.
METHODS: This prospective cross-sectional study was conducted from September to December 2023 at the Wenjiang Hemodialysis Center in the Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China. A total of 244 MHD patients, including 130 males and 114 females, were enrolled. Data were collected prospectively, including demographic information and physical measurements. All participants provided informed consent before enrollment. Measurements were taken post-dialysis to ensure consistency. The whole-body phase angle was measured using the InBody S10 device, grip strength was measured using an electronic grip strength tester, and physical function was assessed by the Short Physical Performance Battery (SPPB). The Skeletal Muscle Index (SMI) was also calculated.
RESULTS: A total of 244 patients receiving hemodialysis were enrolled in this study. Among these, 109 patients were categorized as non-sarcopenic, 111 as having possible sarcopenia, and 24 as sarcopenic. The prevalence of sarcopenia among MHD patients is 9.8%, while the prevalence of possible sarcopenia is 45.5%. The receiver operating characteristic (ROC) curve analysis showed that for male patients, the AUC of PhA for predicting possible sarcopenia was 0.798, with a sensitivity of 80.36%, specificity of 69.70%, and a cutoff value of 6.20°. For female patients, the AUC of PhA was 0.701, with a sensitivity of 70.91% and specificity of 62.79%, and a cutoff value of 5.70°.
CONCLUSIONS: PhA may be a useful and simple predictor of the risk of possible sarcopenia in MHD patients, and more research is needed to further promote the use of PhA in possible sarcopenia.
Histone deacetylase inhibitors in epigenetic therapy are one of the most active anti-tumor agents in patients with relapsed and refractory CTCL despite their suppressive effects on T cell function, yet the overall response rate and response duration with these agents remains suboptimal. Immune stimulatory agents may be the ideal therapy to combine with HDACI. To date, no one has evaluated whether the abscopal effect of radiation with and without the additional immune stimulation of a TLR-3 agonist can augmented the efficacy of anti-tumor directed epigenetic therapy in mycosis fungoides (MF) patients. The investigators hypothesize that a combined modality immuno-chemotherapy may be highly effective in patients with advanced MF.

This is a phase I study. It involves two arms of patients (A and B) who will be treated following a standard 3+ 3 design. Patients on Arm A are the ones who are initiating HDACI therapy, and patients on Arm B are the ones with stable disease or partial response with HDACI treatment. Both groups receive HDACI, plus at level 1, focal lesional radiation; at level 2, radiation in combination with Poly ICLC. Each arm will be evaluated and escalated independently.
Table 4. Description

  


Clobazam is a white or almost white crystalline powder and freely soluble in dichloromethane, sparingly soluble in ethanol and insoluble in water. The melting range of clobazam is from 182.01ºC to 182.98 ºC. The molecular formula is C16H13O2N2Cl and the molecular weight is 300.7.  
Each clobazam tablet contains 10 mg or 20 mg of clobazam. Tablets also contain as inactive ingredients: colloidal silicon dioxide, hydroxy propyl cellulose, lactose monohydrate, maize starch, magnesium stearate, and talc.
After informed consent and central pathology review of the core prostate biopsy, eligible patients who decide to undergo prostatectomy at Johns Hopkins will be scheduled to receive po lovastatin following a four times a day schedule, at the starting dose of 20 mg/kg/day. Following an initial period of monitoring for safety at this entry dose level of one month, we will then accrue patients to dose de-escalation (to 1, and 10 mg/kg/day) cohorts.
Participants will receive 10 mL of placebo (saline) over 2 minutes while asleep during their first overnight visit. Participants will receive 0.2 mg oral clonidine and either 2 mg of IV psilocybin or saline over 2 minutes while asleep during their second overnight visit.
Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) are at increased risk of developing atrial fibrillation (AF). Abnormal P-wave parameters (PWPs) have been identified as independent predictors of AF, however, their prognostic significance in DLBCL patients remains unknown. Newly diagnosed DLBCL patients from January 2015 to August 2022 were retrospectively included in this study. Patients were devided as with abnormal PWPs or without it. Primary outcome was the all-cause mortality. The median duration of follow-up was 16.3 months. The Kaplan‒Meier method and multivariable COX proportional hazards regression models were used to analyze the relationship between PWPs and all-cause mortality. Logistic regression analyses were performed to identify risk factors associated with PWPs. A total of 374 newly diagnosed DLBCL patients were included, of whom 137 patients exhibited abnormalities in PWPs. Compared to the group with normal PWPs, patients with PWPs abnormalities had a higher proportion of males (p = 0.001), elevated levels of blood urea nitrogen (p = 0.038) and blood creatinine (p = 0.005), and a higher rate of all-cause mortality (p = 0.001). PWPs, particularly P-wave duration (p = 0.017) and P-wave terminal force in lead V1 (PTFV1) (p = 0.001), were independently correlated with all-cause mortality in DLBCL patients. Furthermore, male patients exhibited a higher susceptibility to abnormal PWPs (p = 0.001). PWPs, particularly P-wave duration and PTFV1, serve as simple yet effective prognostic indicators for all-cause mortality in DLBCL patients. Consequently, vigilant monitoring of PWPs, particularly in male patients, is warranted to accurately evaluate the prognosis of DLBCL.