anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to traditional Chinese medicine for treating facial palsy, and a preparing method and a using method thereof, which belongs to the field of traditional Chinese medicine. The traditional Chinese medicine for treating facial palsy comprises radix cyathulae and honey, wherein the weight ratio of the radix cyathulae to the honey is (1 to 30) to (1 to 30). After cleaned and dried, the radix cyathulae of Chinese medicinal herb is conveyed in a pulverizer to be pulverized into fine powder. After filtration and bactericidal processing, the radix cyathulae is added in the honey according to a mixture ratio, and is evenly stirred. Then, the medicine is prepared into various preparations according to the preparing method, such as pills, medicine grains, tablets, etc., which are convenient for people to take. Compared with the medicine and the method which are used for treating facial palsy home and abroad at present, the traditional Chinese medicine of the present invention has obvious characteristics of no toxic or side effect and short curative period. An acute patient can completely recover by taking medicine for 1 to 2 days, at most one week. Except for operated patients, diseases can be thoroughly cured, and the curative ratio of the acute patient reaches 100%. Thus, the pain of the patient is largely relieved, and the cost is saved. By clinical tests for many years, the traditional Chinese medicine of the present invention has unique curative effect.
FIELD: medicine. SUBSTANCE: solutions of hydroxycarboxylic acids obtained out of natural raw material as humic substances are treated with potassium tetrachloroplatinate by ultrasound impact at irradiation power being 40 W/cm 2  and 22 kHz frequency for 4-8 min. Humic substances could be obtained by treating humus material with alkaline solutions under normal conditions. As humus material one should use composts, sapropels, high- moor or intermediate-moor peat, humus layers of different soil types, etc. Humic substances could be, also, obtained out of oxidized woody lignin due to treatment with oxygen-bearing gas in alkaline medium at 170 ± 20 C, 1.9-2.5 MPa pressure for 1- 3 h and subsequent cooling the reaction mass, separation of a solid phase against a solution and acidification of the latter up to pH = 2-3. EFFECT: broadened assortment of antitumor preparations obtained out of available material. 8 cl, 7 ex
BACKGROUND: Transcranial Magnetic Stimulation (TMS) studies examining exercise-induced neuroplasticity in pain populations have produced contradictory findings. We conducted a systematic review to explore how exercise impacts cortical excitability in pain populations using TMS metrics. This review aims to summarize the effect sizes and to understand their sources of heterogeneity.
METHODS: We searched multiple databases from inception to December 2022. We included randomized controlled trials (RCTs) with any type of pain population, including acute and chronic pain; exercise interventions were compared to sham exercise or other active interventions. The primary outcomes were TMS metrics, and pain intensity was the secondary outcome. Risk of bias assessment was conducted using the Cochrane tool.
RESULTS: This review included five RCTs (n = 155). The main diagnoses were fibromyalgia and cervical dystonia. The interventions included submaximal contractions, aerobic exercise, physical therapy, and exercise combined with transcranial direct current stimulation. Three studies are considered to have a high risk of bias. All five studies showed significant pain improvement with exercise. The neurophysiological data revealed improvements in cortical excitability measured by motor-evoked potentials; standardized mean difference = 2.06, 95% confidence interval 1.35-2.78, I2 = 19%) but no significant differences in resting motor threshold. The data on intracortical inhibition/facilitation (ICI/ICF) was not systematically analyzed, but one study (n = 45) reported higher ICI and lower ICF after exercise.
CONCLUSIONS: These findings suggest that exercise interventions positively affect pain relief by modifying corticospinal excitability, but their effects on ICI/ICF are still unclear. While the results are inconclusive, they provide a basis for further exploration in this area of research; future studies should focus on establishing standardized TMS measurements and exercise protocols to ensure consistent and reliable findings. A large-scale RCT that examines various exercise interventions and their effects on cortical excitability could offer valuable insights to optimize its application in promoting neuroplasticity in pain populations.
1,191,611. Aryloxyalkanoic acids. MERCK & CO. Inc. 18 March, 1968 [23 March, 1967], No. 13075/68. Heading C2C. Novel aryloxyalkanoic acids (I) (including esters and amides thereof) wherein R is alkyl, cycloalkyl, C 2-5  alkenyl, C 1-5  haloalkyl, carboxy C 1-5  alkyl, C 1-6  alkanoyl, aryl, carboxy substituted aryl, or aralkyl; R<SP>1</SP> is hydrogen or alkyl; the X radicals are the same or different and signify hydrogen, halogen, alkyl and, taken together, two X radicals on adjacent carton atoms of the benzene ring may be joined to form a hydrocarbylene chain containing 3 or 4 carbons between their points of attachment; m is 1 to 4 and n is 1, 2 or 3, are prepared by the interaction of an appropriate mercaptan, RSH, and an intermediate ester of a 2-nitro-1-alkenylaryloxyalkanoic acid (the intermediate ester is prepared by reacting a primary amine with an ester of a formyl-aryloxyalkanoic acid and subsequently reacting the Schiff-base so formed with a nitroalkane) followed, optionally, by hydrolysis; esters and amides are prepared by standard methods. Alkyl formyl phenoxy-alkanoates (which may be substituted by X m ) are prepared by the interaction of the appropriate nuclear substituted hydroxy-arylaldehyde (obtained by reacting the corresponding phenol with chloroform in the presence of calcium hydroxide and sodium carbonate followed by acidification) and a haloalkanoic acid ester or an appropriately substituted propiolactone in the presence of a base; they may also be prepared by reacting the appropriate phenoxyalkanoic acid ester with formaldehyde and concentrated hydrochloric acid followed by treatment of the product so formed with hexamethylenetetramine. Ethyl-(2,3-dimethylphenoxy)acetate which is obtained by the interaction of 2,3-dimethylphenol and ethyl bromoacetate, is converted to ethyl - (2,3 - dimethyl - 4 - chloromethyl - phenoxy)- acetate by reaction with formaldehyde in the presence of concentrated hydrochloric acid. 3 - (2,3 - Dichloro - 4 -formylphenoxy) propionic acid is obtained from 2,3-dichloro-4-hydroxybenzaldehyde and #-propiolactone in the presence of acid; the corresponding ethyl ester is also described. [2,3 Dichloro - 4 - (1 - phenylthio - 2 - nitropropyl) phenoxy] acetyl chloride is obtained from the corresponding free acid utilizing thionyl chloride. Pharmaceutical preparations showing diuretic and saluretic activity contain as active ingredient compounds (I); administration is orally or by intravenous injection.
The study population will consist of 50 women with POI as a study group and 50 patients with normal healthy women as a control group. A volunteer group of healthy women who will be visited the gynecology clinic for routine examinations and women who will be admitted for pre-pregnancy tests will be invited randomly to this research as a control group.
Analytics are used for live streaming based on image analysis within a shared digital environment. A group of images is obtained from a group of participants involved in an interactive digital environment. The interactive digital environment can be a shared digital environment. The interactive digital environment can be a gaming environment. Emotional content within the group of images is analyzed for a set of participants within the group of participants. Results of the analyzing of the emotional content within the group of images are provided to a second set of participants within the group of participants. The analyzing emotional content includes identifying an image of an individual, identifying a face of the individual, determining facial regions, and performing content evaluation based on applying image classifiers.
One of the key challenges in healthcare and personal care industries is arriving at an optimum delivery vehicle and formulation which can deliver a specified active molecule to an intended site of action with minimal or no side effects. This disclosure relates to method of designing and testing of a vehicle and formulation for delivery of an active molecule. A plurality of inputs is processed to generate plurality of drug delivery routes. The vehicle associated with formulation is designed based on plurality of parameters associated with the active molecule and the plurality of drug delivery routes. The designed vehicle associated with the formulation on an in-silico model of corresponding chosen drug delivery route is tested to obtain data associated with delivery of the active molecule. The data associated with delivery of the active molecule is reiteratively processed to obtain a desired data associated with the delivery of the active molecule.
FIELD: cosmetics. SUBSTANCE: gel comprises gelling and moistening substances, vitamin C, biologically active additive, perfume composition, water, and additionally comprises dimethicone and/or cyclomethicone, Trilon B, triethanolamine or sodium hydroxide or caustic soda, bronopol or bronitrols, or KATOH CG germaben II. Gel further comprises propylene glycol and allantoin as moistening substances, and hydrolyzed milk protein or milk-peptide complex, water-alcoholic or water-alcoholic-glycerin extract of cornflowers, green tea extract in propylene glycol or water-alcoholic-glycerin sweet-Mary extract as biologically active additives, stabilized form of sodium or magnesium ascorbilphosphate as vitamin C, carbopol or carbomers or CAKAП, or CAKAП-P as gelling substances. Components are used in predetermined ratio. Gel does not produce toxic, skin irritating and sensitizing effect. EFFECT: increased effectiveness in skin caring. 2 tbl
Participants receive 800 mg MK-3795 orally twice daily. Participants may continue to receive MK-3795 in the absence of unacceptable treatment related toxicity or unequivocal disease progression.
PURPOSE:To provide a baby powder composition low in scattering tendency, high in fluidity, good in the adherability to and spreadability on the skin, also preferable in skin touch. CONSTITUTION:The objective baby powder composition having the above- mentioned advantages is formulated by containing, as a main ingredient, pref. 80-90wt.% of spherical and/or disc-shaped fine talc particles having a mean diameter of 10-50mum. The fine particles can be obtained by sorting of talc having 1-70mum particle diameter prepared by grinding the original talc with a ball mill or pin mill, using e.g. an ultrafine powder sorter, Type 450, manufactured by Donaldson Japan Ltd., a kind of wind-power sorter, at the rotor revolution of 1000-5000rpm and wind velocity of 2.0-2.5m/min. This composition can be blended arbitrarily with other powdery base(s) such as emollients, coloring matter, antifungal agent, bactericide, or fragrance to formulate the objective composition after thorough dispersion and mixing thereof.
BACKGROUND: Patients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of extracellular matrix (ECM) proteins. While ECM accumulation can prevent liver infection and injury, it can destroy normal liver function and architecture. miRNA's own regulation was involved in DNA methylation change. The purpose of this study is to detect DNA methylation landscape of miRNAs genes in mice liver fibrosis tissues.
METHODS: Male mice (10-12 weeks) were injected CCl4 from abdominal cavity to induced liver fibrosis. 850 K BeadChips were used to examine DNA methylation change in whole genome. The methylation change of 16 CpG dinucleotides located in promoter regions of 4 miRNA genes were detected by bisulfite sequencing polymerase chain reaction (BSP) to verify chip data accuracy, and these 4 miRNA genes' expressions were detected by RT-qPCR methods.
RESULTS: There are 769 differential methylation sites (DMS) in total between fibrotic liver tissue and normal mice liver tissue, which were related with 148 different miRNA genes. Chips array data were confirmed by bisulfite sequencing polymerase chain reaction (R = 0.953; P < 0.01). GO analysis of the target genes of 2 miRNA revealed that protein binding, cytoplasm and chromatin binding activity were commonly enriched; KEGG pathway enrichment analysis displayed that TGF-beta signaling pathway was commonly enriched.
CONCLUSION: The DNA of 148 miRNA genes was found to have methylation change in liver fibrosis tissue. These discoveries in miRNA genes are beneficial to future miRNA function research in liver fibrosis.
BACKGROUND AND PURPOSE: Olfaction is an early marker of neurodegenerative disease. Standard olfactory function is essential due to the importance of olfaction in human life. The psychophysical evaluation assesses the olfactory function commonly. It is patient-reported, and results rely on the patient's answers and collaboration. However, methodological difficulties attributed to the psychophysical evaluation of olfactory-related cerebral areas led to limited assessment of olfactory function in the human brain.
MATERIALS AND METHODS: The current study utilized clustering approaches to assess olfactory function in fMRI data and used brain activity to parcellate the brain with homogeneous properties. Deep neural network architecture based on ResNet convolutional neural networks (CNN) and Long Short-Term Model (LSTM) designed to classify healthy with olfactory disorders subjects.
RESULTS: The fMRI result obtained by k-means unsupervised machine learning model was within the expected outcome and similar to those found with the conn toolbox in detecting active areas. There was no significant difference between the means of subjects and every subject. Proposing a CRNN deep learning model to classify fMRI data in two different healthy and with olfactory disorders groups leads to an accuracy score of 97 %.
CONCLUSIONS: The K-means unsupervised algorithm can detect the active regions in the brain and analyze olfactory function. Classification results prove the CNN-LSTM architecture using ResNet provides the best accuracy score in olfactory fMRI data. It is the first attempt conducted on olfactory fMRI data in detail until now.
FIELD: medicine. SUBSTANCE: the suggested preparation is based upon probiotics enriched with microelements in the form of different salts, both organic and inorganic compounds available for metabolic processes in alive organism and introduced into probiotic foundation at different stages of biotechnological process. The quantity of microelements introduced is sufficient for development of microorganisms properly that take part in mineral exchange with a macroorganism, and additional supply of macroorganism with vitally important chemical elements. For example, calcium could be applied as gluconate to provide new range of curative and prophylactic action of probiotics based upon bifidobacteria in case of disorders of calcium exchange. The present innovation enables to obtain dosed forms of medicinal preparations of new class. EFFECT: higher efficiency. 4 cl, 4 ex, 1 tbl
Novel compounds are provided that bind to polo-like kinases through the polo -box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo- like kinases through the polo -box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds. The compounds of the invention have potential therapeutic activity in view of their binding and inhibitory activities towards Plkl. They are based on the amino acid sequence PLHSpT (phosphorylated Thr). The PEG moiety, when present, is covalently attached at the N- terminus. The invention also encompasses derivatives having substituents on the Pro and/or the His side chains, substituents on the phosphate group, the replacement of His with Gln, the replacement of Pro with a N-substituted Gly, the replacement of Ser with Ala, as well as HS-pT fragments with N-terminal alkoxycarbonyl group and PLHS fragments with a C-terminal glyco-imino-alkylxyalkylamide group.
Glycolysis is the fundamental cellular process that permits cancer cells to convert energy and grow anaerobically. Recent developments in molecular biology have made it evident that mitochondrial respiration is critical to tumor growth and treatment response. As the principal organelle of cellular energy conversion, mitochondria can rapidly alter cellular metabolic processes, thereby fueling malignancies and contributing to treatment resistance. This review emphasizes the significance of mitochondrial biogenesis, turnover, DNA copy number, and mutations in bioenergetic system regulation. Tumorigenesis requires an intricate cascade of metabolic pathways that includes rewiring of the tricarboxylic acid (TCA) cycle, electron transport chain and oxidative phosphorylation, supply of intermediate metabolites of the TCA cycle through amino acids, and the interaction between mitochondria and lipid metabolism. Cancer recurrence or resistance to therapy often results from the cooperation of several cellular defense mechanisms, most of which are connected to mitochondria. Many clinical trials are underway to assess the effectiveness of inhibiting mitochondrial respiration as a potential cancer therapeutic. We aim to summarize innovative strategies and therapeutic targets by conducting a comprehensive review of recent studies on the relationship between mitochondrial metabolism, tumor development and therapeutic resistance.
Approximately 135 subjects will receive oral TU treatment during the study for approximately 3.5 months. Subjects randomly assigned to the oral TU treatment group will begin treatment at a dose of 237 mg TU twice daily (BID).
NEW MATERIAL:A 24,24-difluoro-26,27-dimethylvitamin D3 derivative expressed by formula I (X is H or OH). EXAMPLE:3beta-24zeta-Dihydroxy-24-tris(methylthio)methylchol-5-ene. USE:A medicine, having osteogenetic action and useful for treating and preventing various diseases caused by abnormality and disorder of calcium regulation or calcium absorption, e.g. calcium dysbolism or osteoporosis, etc. PREPARATION:A compound expressed by formula II (Y<1> is H or acyloxy; Z<1> is acyl) is fluorinated and ethylated. A double bond is then introduced thereinto to give a compound expressed by formula III, which is then irradiated with ultraviolet rays at -20-+120 deg.C for 1-2hr using a mercury lamp, etc., to afford the aimed compound expressed by formula I.
In PVB group before the induction of general anaesthesia a single shot thoracic paravertebral blockade was performed. ThPVB was performed on Th7-Th10 level, approximately 2,5 - 3 cm lateral from the top of the spinous process with prior ultrasound control of the depth of the transverse process and the pleura. To make the procedure safer the investigators used peripheral nerve stimulation with an isolated 10 cm needle with a start current of 2,5 mA. The needle was inserted until visible muscle activity from intercostal muscles appeared, with a current of 0,5-0,3mA (paravertebral space identification). Next 0,3 ml kg-1 0,5% plain bupivacaine was injected after negative aspiration for air and blood. The efficacy of the blockade was checked after 20 minutes with cold saline.

In both groups, PVB and GEN general anaesthesia was induced with midazolam 0,1 mgkg-1, propofol 2 mgkg-1, cis-atracurium 0,15 mgkg-1 and fentanyl 1,5 µgkg-1. Patients were intubated with a standard single lumen tracheal tube. Anaesthesia was maintained with 1 MAC (Minimal Alveolar Concentration) sevoflurane. For surgical analgesia the investigators used fractional doses of fentanyl 1-3 mg kg-1 if HR (heart rate) or MBP (mean blood pressure) raised above 20% of basal values. Waking up from anaesthesia was in a post-anaesthesia care unit.

Postoperative pain management schedule was identical in both groups. After the surgery, if pain appeared, the patient was given oxycodone i.v. titrated to achieve acceptable analgesia level or until side effects appeared. Every patient received a PCA (Patient controlled analgesia) device with a 1 mgml-1 concentration oxycodone solution with a programmed single bolus dose of 1 mg and a lockout time of 5 minutes. Additionally, patients were given 1g i.v. paracetamol every 6 hours and 100 mg of i.v. ketoprofen every 12 hours.

For 48 h postoperatively, the investigators monitored HR, SBP (systolic blood pressure) , DBP (diastolic blood pressure), sedation level in Ramsay scale, pain intensity at rest in VAS (visual analogue score) scale, oxycodone requirement in pre-selected time points and total oxycodone requirement. The investigators also recorded opioid-related adverse events 24 and 48 h postoperatively in OBAS scale and patients' satisfaction regarding postoperative analgesia 48 h postoperatively in Likert scale.