anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The application relates to the technical field of minimally invasive surgery interaction navigation guided by preoperative three-dimensional planning, and discloses a 3D man-machine interaction type endoscopic surgery navigation system, which comprises a preoperative image acquisition module: for acquiring medical image data of a patient. And a three-dimensional reconstruction module: the method is used for carrying out three-dimensional reconstruction on preoperative image data to generate a three-dimensional model of the anatomical structure. Preoperative operation planning module: for mapping surgical steps in a standard procedure to three-dimensional anatomy. The real-time cavity mirror image acquisition module is used for: the method is used for acquiring the intra-operative real-time endoscopic image and matching with the three-dimensional reconstruction module. Through the preoperative image acquisition module, the three-dimensional reconstruction module and the preoperative operation planning module, the system can generate a three-dimensional model of the anatomy structure of the patient and match the three-dimensional model with the real-time endoscopic image. In this way, the surgeon can accurately locate and identify anatomical structures during the procedure, thereby improving the accuracy of the procedure.
Lactating women with CIS or MS (in line with the locally approved indications) who decided together with their treating physician to continue on, or start treatment with, OCREVUS (ocrelizumab) post-partum. Women resuming treatment with ocrelizumab post-partum will be included only if the last exposure to ocrelizumab occurred more than 3 months before the last menstrual period to exclude any interference between fetal exposure and exposure via lactation.
From 8:00 on the day before colonoscopy, oral fluids including juice, rice soup, filtered vegetable juice/broth, lotus root powder and milk and egg soup were taken to ensure energy intake and blood glucose stability. The fasting starts at 9:00 AM on the day of colonoscopy.
Two sessions a week for two weeks of: 5 minutes listening to audio book excerpts followed by 20 minutes of audio guided mindfulness practice. Participants will be asked not to engage in formal mindfulness practice outside of these sessions during the study.
Participants with rheumatoid arthritis (RA) in Canada, will be observed for 24 months. Only data available from source documentation will be collected.
The classic association of glycemic control, as represented by HBa1c, with progression or improvement of microvascular and macrovascular clinical complications has been well documented. Additionally, while the association of HBa1c elevation with a syndrome described as diabetic cardiomyopathy has also been well documented, the use of the advanced glycation end product axis (AGE/sRAGE/esRAGE which includes HBa1c) as markers for the early subclinical hemodynamic changes of diabetic cardiomyopathy has been suggested but less well characterized or utilized. Stage A heart failure is defined as persons with normal cardiac structure and function who have predisposing subclinical risks for cardiovascular disease. Estimates suggest that Stage A heart failure may comprise up to 56% of any community's patient population and are patients most commonly seen in non-specialty primary care clinics. In light of newer cardiometabolic agents which show promise in cardiovascular disease primary prevention, these patients may be an important target for preventative cardiometabolic care. In a retrospective community based cohort study from Pueblo County Colorado which has a higher population proportion of metabolic syndrome and diabetes mellitus, we hope to clarify and quantify an association of the AGE HBa1c elevation with the early subclinical hemodynamic changes of diabetic cardiomyopathy as measured by LAV, LVM, E/A ratio, E/e' ratio and BNP in patients with stage A heart failure.

Methods: Retrospective cohort analysis by chart review of patients presenting to Parkview Medical Center's inpatient service and outpatient clinics who obtained a full resting echo characterized by normal cardiac structure and function in conjunction with HBa1c and BNP levels within a 3 month time window. Using multiple regression analysis of the dependent variables LAV, LVM, E/A ratio, E/e' ratio and BNP, powered to detect a 5% change in LAV in conjunction with rising HBa1c levels characterized as normal (\<5.7), metabolic syndrome (5.7-6.4) or diabetic (\>6.4) after controlling for the presence of hypertension and coronary artery disease.
On smartphones, participants in this arm will receive twice daily and weekly prompts to report on behaviors under study and be able to send self-initiated event-contingent reports on behaviors under study. In response to the behaviors they report, they receive messages on their smartphones supporting ongoing healthy behaviors or suggesting alternative behaviors to limit risks. They will complete in-person assessments at enrollment, 30-days and study exit at 90-days.
Patients receive niraparib PO QD. Cycles repeat every 28 days for 15 months in the absence of disease progression or unacceptable toxicity.
Dento-alveolar trauma may affect the quality of life of patients and the long term prognosis of the teeth. Following dental trauma regular monitoring and follow up of the teeth is required to ensure that the appropriate treatment is delivered promptly. Although there is information in the literature focused on child and adolescent dental trauma, there is limited information regarding traumatised permanent teeth. Permanent teeth have differing healing capacity after injury and this is dependent on the degree of root formation.

During the initial assessment of patients that have suffered from dental trauma, negative responses to investigations assessing the health of the vasculature might lead clinicians to initiate unnecessary and irreversible treatment on traumatised teeth. Equally false positive results might delay treatment which might have an effect on the outcome, leading to the development of healing complications such as infection and root resorption. By collecting and analysing the clinical factors, we aim to identify which of aspects of the assessment might influence the prognoses of the teeth.
PURPOSE:To provide a toothpaste composition having high safety and excellent cleaning effect with low abrasion of the teeth, by using a water-insoluble cellulose powder as an abrasive material. CONSTITUTION:A toothpaste composition containing 1-70wt%, pref. 10-50wt% of water-insoluble cellulose powder, such as pulp powder, insoluble powdery cellulose, powdery alpha-cellulose, etc. The average particle diameter of the powder is pref. 0.005-1mm, esp. 0.02-0.5mm (dried state), and the bulk density is pref. 0.05- 1.0g/cc, esp. 0.15-0.5g/cc (dried state). Low abrasion of the teeth compared with conventional inorganic abrasive materials is obtained. It is also effective to clean the oral cavity and to remove foul breath by the strong adsorptive affinity of dyestuff to the water-insoluble cellulose powder.
Group of patients of any age, any sex, that will receive a complete scheme of approved Ad5-nCoV vaccination, assigned by a local government vaccination campaign. It can also include patients that receive a third or fourth boost.
Biologic ant targeted synthetic disease modifying anti-rheumatic drugs (bDMARDs and tsDMARDs) have greatly improved the prognosis of chronic inflammatory diseases. To date, many bDMARDs and tsDMARDs targeting different immunologic mechanisms are available to treat RA, SpA or PsA. However, the choice of the treatment and its mechanism of action is based on physician decision and experience. Indeed, predictive clinical and biological factors associated with therapeutic response that could help the physician to make his/her choice are lacking. The aim of BIOTOUL is to collect and store biologic samples in patients with RA, SpA or PsA who begin a new bDMARD or tsDMARD. This biobank will permit to study several biomarkers and assess the association between such markers and response to therapy.

Furthermore, osteoporosis is a chronic disease leading to fractures and disability. Several ant-osteoporotic drugs are now available and biomarker(s) that would help the physician to choose the best therapeutic sequence are lacking. BIOTOUL will also include patients with osteoporosis to identify biomarkers associated with severity and response to anti-osteoporotic treatments.
Single Arm - Drug administered on Days 1-7 and Days 15-21 of a 28-day treatment cycle. Series of Pharmacokinetics and ECGs will be done during cycle 1.
A method and/or system for customizing wound dressings based on an effective wound treatment protocol created by collecting and analyzing wound treatment records. The wound treatment records are collected from one or more wound treatment facilities. The wound dressings are not customized for each patient based solely on experiences and knowledge of medical practitioners but also based on the wound treatment protocol. Further, an intuitive and systematic user interface for a wound dressing fabricator is provided to allow medical practitioners with varying levels of experiences and knowledge to customize wound dressings for a specific wound. By using the wound treatment protocol and the systematic user interface, flawed wound dressings are less likely to be fabricated. Various other functionalities are also provided to manage and support the wound dressing fabricator.
A skin-cleansing cream is made by incorporating magnesium hydroxide with a wax and a viscous oily material.  The magnesium hydroxide is used in the form of an aqueous suspension and amounts to 0,5--6 per cent of the total weight.  White beeswax, spermaceti, ceresin, or paraffin wax, in amounts varying from 1--6 per cent of the total weight, and mineral oil, petrolatum or mixtures thereof, or vegetable oils are employed.  Mineral oil and petrolatum may each constitute 30--60 per cent of the product. The water content may vary from 10--30 per cent.  A little borax assists the emulsification, and perfumes or colouring agents may be added.  The wax, mineral oil, and petrolatum are heated to about 170 DEG  F., a mixture of borax with a suspension of magnesium hydroxide added, and the product further heated at 170 DEG  F. with agitation to give a semicolloidal suspension.  This is cooled, perfume being added when the temperature is about 110 DEG  F. Specification 368,458, [Group VI], is referred to.
PURPOSE:To obtain a facial pack sheet applicable simply by cutting to a necessary size and applying to the face, by adding a hydrogenated lecithin to a hydrocarbon oil gel, adding the gel to a styrene-isoprene thermoplastic elastomer and applying the obtained base to a substrate. CONSTITUTION:A styrene-isoprene thermoplastic elastomer is mixed to a hydrocarbon oil such as liquid paraffin at an amount of 20-90wt%. A beautifying component is added to the mixture and the obtained base is coated to a substrate (e.g. nonwoven cloth, woven cloth or film) to obtain a facial pack sheet. The affinity and feeling etc., to the skin can be improved by using a beautifying component in combination with a hydrocarbon oil gel added with hydrogenated lecithin. The molecular weight of the styrene-isoprene thermoplastic elastomer is preferably 120,000-140,000.
Predicting drug toxicity is a critical aspect of ensuring patient safety during the drug design process. Although conventional machine learning techniques have shown some success in this field, the scarcity of annotated toxicity data poses a significant challenge in enhancing models' performance. In this study, we explore the potential of leveraging large unlabeled small molecule data sets using semisupervised learning to improve drug cardiotoxicity predictive performance across three cardiac ion channel targets: the voltage-gated potassium channel (hERG), the voltage-gated sodium channel (Nav1.5), and the voltage-gated calcium channel (Cav1.2). We extensively mined the ChEMBL database, comprising approximately 2 million small molecules, and then employed semisupervised learning to construct robust classification models for this purpose. We achieved a performance boost on highly diverse (i.e., structurally dissimilar) test data sets across all three targets. Using our built models, we screened the whole ChEMBL database and a large set of FDA-approved drugs, identifying several compounds with potential cardiac ion channel activity. To ensure broad accessibility and usability for both technical and nontechnical users, we developed a cross-platform graphical user interface that allows users to make predictions and gain insights into the cardiotoxicity of drugs and other small molecules. The software is made available as open source under the permissive MIT license at https://github.com/issararab/CToxPred2.
Ischemic compression group received ischemic compression and standardized exercise program twice a week for 6 weeks. Each session takes 50 minutes.
NEW MATERIAL:A compound shown by the formula I (R<1> is lower alkyl; R<2> is H, or lower alkyl). EXAMPLE:Ethyl 5- fluoro- 6-( Z )- furfuryldeneaminooxy- 1,2,3,4,5,6-hexahydro-2, 4- dioxopyrimidine-5-carboxylate. USE:Useful as an antitumor agent for various kinds of solid cancers (cancers of digestive organs). Having extremely improved antitumor effect as compared with other methyleneaminooxydihydrouracils. Showing relatively low toxicity, capable of being administered safely. Having improved absorption even by oral medication, and improved conversion ratio to 5-FU in the body. PROCESS:A compound shown by the formula II (R<3> is hydrocarbon reside) is reacted with a compound shown by the formula III in the presence of a solvent such as acetone, etc. using a catalyst such as pyridine under cooling - at about 100 deg.C, to give a compound shown by the formula I .
TQB3909 Tablets, orally administered. 28 days as a treatment cycle.
Following intravenous injection, IC‑GREEN™ is rapidly bound to plasma protein, of which albumin is the principle carrier (95%). IC‑GREEN™ undergoes no significant extrahepatic or enterohepatic circulation; simultaneous arterial and venous blood estimations have shown negligible renal, peripheral, lung or cerebro-spinal uptake of the dye. IC‑GREEN™ is taken up from the plasma almost exclusively by the hepatic parenchymal cells and is secreted entirely into the bile. After biliary obstruction, the dye appears in the hepatic lymph, independently of the bile, suggesting that the biliary mucosa is sufficiently intact to prevent diffusion of the dye, though allowing diffusion of bilirubin. These characteristics make IC‑GREEN™ a helpful index of hepatic function. 

The plasma fractional disappearance rate at the recommended 0.5 mg/kg dose has been reported to be significantly greater in women than in men, although there was no significant difference in the calculated value for clearance.
All patients underwent twenty-four Ekso sessions, scheduled 3 times a week. Each session lasted about 1h, and included transferring into the device arranged on an office chair; donning, standing, walking, sitting, doffing; and transferring out of the exoskeleton.The user can stand up, sit down, and walk with help of a front-wheeled walker and with the exoskeleton attached to a ceiling rail tether. A physical therapist initially provides assistance to maintain the user's center of mass over the base of support to prevent falling.
A cap, e.g. a mobcap, comprising an acid which is chemically not bonded thereto, may be used to neutralize ammonia released during hair coloration by: <SL> <LI>(a) applying to hair an oxidative dye composition comprising aqueous ammonia and <LI>(b) subsequently cover the hair with such a cap. </SL> A package comprising such a cap and an oxidative hair colorant product is also provided. Suitable acids include citric acid, formic acid, lactic acid, acetic acid, malic acid, hypochloric acid and sulphuric acid. The cap may comprise an absorbent layer, e.g. of a cellulosic (such as paper), wool, cotton or suitable polymeric material. The cap may also comprise a pH-sensitive colour indicator (to indicate when the hair colouration process has finished), a perfume and a malodour counteracting agent.
NEW MATERIAL:A substance having the following physical and chemical properties. Elementary analysis value (%): H 6.75, C 45.28, N 13.63. Specific rotatory power: [alpha]D<30>=-76.6. Solubility: easily soluble in water, 0.01N HCl and 0.01N NaOH. Color reaction: positive in biuret reaction, copper-Folin's reaction. Appearance: white powder, and its aqueous solution is colorless. Molecular weight: about 60 kilodalton. USE:Having lymphoma growth effect, useful for preparing a physiologically active substance (e.g., interferon) by an animal cell (e.g., namarupa cell, or melanoma cell). PROCESS:Grown bovine serum is gelled with glacial acetic acid, the gel is homogenized and centrifuged to give a supernatant liquid. The supernatant liquid is dialyzed to remove acetic acid, ultrafiltered, lyophilized, the dried material is suspended in a base medium for cultivating an animal cell, an active ingredient is extracted a soluble part is subjected to gel filtratin, and the active ingredient is purified to give the desired substance.
Despite strict hand washing, sterile technique, and antibiotic-coated catheters, nosocomial infection and sepsis remain the leading acquired causes of morbidity and mortality in critically ill children. Subsequent use of antibiotics to treat nosocomial infection and sepsis is considered a major attributable factor in the rise of antibiotic-resistant organisms in this population of children. Presently, "prophylaxis" strategies are used to prevent stress-induced gastrointestinal bleeding; however, no "prophylaxis" strategy is used to prevent stress-induced nosocomial infection and sepsis. When left unopposed, the stress hormone, cortisol, induces lymphocyte apoptosis, lymphopenia, and immune insufficiency. Prolactin is the counter-regulatory stress hormone that prevents cortisol-induced apoptosis and immunosuppression. Zinc, selenium, and glutamine are also important in maintenance of lymphocyte health. Critically ill patients commonly develop hypoprolactinemia secondary to increased central nervous system dopaminergic activity, as well as zinc, selenium, and glutamine deficiency caused by increased utilization and decreased supply. Hypoprolactinemia can be prevented by metoclopramide, a dopamine 2 receptor antagonist commonly used as a prokinetic in children, and zinc, selenium, and glutamine deficiency can be prevented with enteral supplementation. This study will use a double-blind randomized controlled trial design to test the hypothesis that daily prophylaxis with metoclopramide, zinc, selenium and glutamine will reduce nosocomial infection and sepsis in critically ill children.
The invention discloses a weight-reducing drink for maidens. The weight-reducing drink comprises, by mass, 6-10 parts of rehmannia glutinosa, 15-20 parts of Chinese wolfberries, 15-20 parts of Chinese yams, 15-20 parts of red dates, 8-12 parts of lotus leaves, 10-15 parts of hawthorn fruits, 5-8 parts of glossy privet fruits, 10-15 parts of liquorice and 25-30 parts of honey. The invention further discloses two preparation methods. The raw material compositions have the main effects of promoting physical development, expelling toxins for beautifying, moistening the lungs, removing qi stagnation, promoting production of body fluid, benefiting qi, regulating blood lipids, reducing blood sugar and cholesterol, promoting hematopoiesis, removing thick fat and scraping off grease. Through the combination of nourishing and diminishing, the weight-reducing drink can promote the health, strengthen the spleen, harmonize the stomach without affecting diets, expel toxins for beautifying, nourish the kidneys, moisten the lungs, promote production of body fluid and benefit qi if drunk daily. The weight-reducing drink tastes sweet and fragrant, meets the physiological needs of maidens and achieves the double effects of diet fitness and weight reduction.
Hearing impairment, a rare inherited condition, is notably prevalent in populations with high rates of consanguinity. The most common form observed globally is autosomal recessive non-syndromic hearing loss. Despite its prevalence, this genetic disorder is characterized by a substantial genetic diversity, making diagnosis and screening challenging. The emergence of advanced next-generation sequencing (NGS) technologies has significantly advanced the discovery of genes and variants linked to various conditions, such as hearing loss. In this study, our objective was to identify the specific variant causing hearing loss in a family from Syria using clinical exome sequencing. The proband in the family exhibited profound deafness as shown by pure-tone audiometry results. The analysis of the different variants obtained by NGS revealed the presence of a nonsense mutation within the CLDN14 gene. Through Sanger sequencing, we verified that this variant segregates with the disease and was not present in the control population. Moreover, we conducted a comprehensive review of all reported deafness-related CLDN14 mutations and their associated phenotypes. Furthermore, we endeavored to carry out a comparative analysis between the CLDN14 and GJB2 genes, with the objective of identifying potential factors that could explain the notable discrepancy in mutation frequency between these two genes.
INTRODUCTION: Hearing loss is a chronic health condition that rises sharply with age. The way people respond to and cope with health conditions is influenced by their capacity to perform illness and treatment-related work. The aim was to explore the cumulative burdens of living with hearing loss and the resources mobilised to ease the burdens.
METHODS: A qualitative design was used with semi-structured interviews (online or in-person) with participants recruited through audiology services and nonclinical services, such as lip-reading classes. Forty-six participants with hearing loss aged between 16 and 96 years were interviewed. An abductive approach, informed by May et al.'s burden of treatment theory, was used to analyse the data.
RESULTS: The illness burden involved participants working to make sense of their hearing loss, engaging in emotional work in response to changes in sound, social interactions and identity and coping with the daily frustrations required to communicate with others. Abandonment and uncertainty characterised the treatment burden; participants engaged in emotional work to adjust to hearing technology and deal with the uncertainty of how their hearing might progress. To ameliorate the burdens, participants drew on internal resources (psychological, health literacy, cognitive) and external resources (social support, financial, information, technology).
CONCLUSIONS: The workload of hearing loss appears largely devolved to the patient and is not always visible. Our work indicates the need to widen approaches in audiological care through the implementation of lifeworld-led care, family-centred care and peer support to build support for those with hearing loss.
PATIENT OR PUBLIC CONTRIBUTION: We developed the project in consultation with members of the public who have lived experience of hearing loss recruited through Aston University and volunteer links to audiology services. We also consulted people more likely to be affected by hearing loss adults including adults with learning disabilities, older adults in residential care and people from South Asia (Bangladeshi, Indian and Pakistani communities). These individuals commented on the study aims, interview schedule and participant recruitment practices. One of our co-authors (expert by experience) contributed to the development and interpretation of themes and preparation of the final manuscript.