anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
To assist in the work of narrowing down on a strain from the image of a Gram-stained specimen.SOLUTION: A classification result input unit 203 inputs the result of classification carried out by a person on the basis of the color and shape, etc., of a bacterium included in a specimen image, to a server device 10. A specimen image storage unit 102 stores the inputted result of classification in association with the specimen image. A classification unit 105 learns the relationship of the result of bacterium classification carried out by a person with the features of the image, and classifies the bacteria included in a specimen image from the features of the specimen image. A specimen image storage unit 102 stores the result of classification carried out with respect to a specimen image by the classification unit 105 in association with the specimen image. The classification unit 105 classifies bacteria with respect to the image of a new specimen. A similar classification image extraction unit 106 extracts a specimen image stored in association with a classification that is similar to the result of classification carried out with respect to the image of the new specimen by the classification unit 105, and outputs it.SELECTED DRAWING: Figure 4
Resistance of insulin-mediated glucose transport is a fundamental early defect in the pathogenesis of type 2 diabetes mellitus (DM). It has been found that high fiber concentration in meal is frequently associated with low GI. In many single-blind cross-over study, short term consumption of high fiber meal has been shown to enhance postprandial insulin sensitivity in healthy subjects. We presume that increasing daily consumption of fiber would improve the insulin resistance and therefor glycemic parameters patients with DM. Patients with type 2 diabetes with stable dose of hypoglycemic medication control will be recruited, two types of meals will be given, type A is a general Asian rice-meal and type B consists of the same rice with multiple-grain-fiber added. Both type of meals will be consumed for 3 months by each patients.
BACKGROUND: Preoperative anxiety is a common preoperative psychological state in patients with cancer and associated with worsening perioperative outcomes. However, high-quality prospective studies on preoperative anxiety in patients undergoing lung surgery are scarce.
METHODS: We conducted a prospective cohort study, enrolling a total of 540 patients. Preoperative anxiety in patients undergoing thoracic surgery was measured using the Hospitalization Anxiety Scale. Patients were grouped according to the Hospitalization Anxiety Scale scores as follows: no anxiety (score <8) and anxiety (score ≥8). The association of preoperative anxiety with postoperative complications and non-complicated adverse events was determined by univariate regression and polynomial regression analyses.
RESULTS: A total of 121 patients (22.4 %) experienced preoperative anxiety. The anxiety group had a longer average hospital stay (4.33 vs. 3.85 days). Postoperative complications were similar between groups, but the anxiety group reported worse sleep quality (measured by the Athens Insomnia Scale). Regarding postoperative pain, both groups had comparable rates of mild and severe pain on postoperative day 1. However, the anxiety group experienced significantly higher rates of severe pain on postoperative day 2 and mild pain on postoperative day 3. Additionally, the incidence of postoperative nausea and vomiting was significantly higher in the anxiety group on postoperative day 1.
CONCLUSIONS: Preoperative anxiety may not increase the rates of postoperative complications in patients undergoing lung surgery. However, it may be associated with postoperative sleep disturbances, pain, nausea, and vomiting, as well as prolong the length of postoperative hospitalization.
PURPOSE:To obtain an immunological drug consisting of an optically active substance capable of exhibiting optical activity by irradiation with laser. CONSTITUTION:An immunological drug obtained by linking an optically active substance capable of exhibiting optical activity by irradiation with laser [e.g. pheophorbide alpha (phd) or tenhydroxypheophorbide alpha] preferably further to a monoclonal antibody for immunodeficiency virus (e.g. human monoclonal antibody for acquired immunodeficiency syndrome, human monoclonal antibody for adult T cell leukemic virus or hepatitis B type virus human monoclonal antibody). When the tenhydroxypheophorbide having high optical activity is used as the optically active substance, respective viral cells can be heat-treated at a higher temperature in a shorter time by irradiating with laser, especially YAG laser. As a result, damage of healthy cells can be reduced in irradiating human bodies with the laser.
Experimental: Patients without a prostate cancer diagnosis after TRUS biopsy. Prostate Biopsy (TRUS-guided). Preparation: Explain procedure, benefits, and risks; obtain consent. Administer antibiotics; discontinue blood thinners. No bowel prep. Procedure: Patient lies on their side or in lithotomy position. Apply local anesthetic. Insert lubricated ultrasound probe into rectum. Guide thin needle into prostate using ultrasound. Take 10-12 tissue samples. Post-procedure: Monitor for complications. Continue antibiotics, drink fluids, avoid strenuous activity, monitor for complications. Minor blood in urine, semen, or rectum may occur, resolving in days to weeks. Follow-up: Discuss biopsy results within a week. Expected result: Absence of prostate cancer.
Regular exercise and dynamic life style can prevent and treat disability, as well as promote mental health and quality of life. In addition to chronic illness, reduced muscle mass and strength as part of aging, affect the daily activities of living of the elderly and their independent lifestyle. In fact, exercise had found positive effects on lower limb weakness of the elderly. Elastic band is a resistance training aid which can be used for different muscle weight training. The research results have been demonstrated elastic band resistance training is safe and effective strategy to apply in the elderly population and to improve physical fitness, and mental functioning. Therefore, this study will examine the effects of low-resistance elastic band training on muscle strength, flexibility, quality of life and ease of care among the nursing home residents. Nursing homes with more than 50 beds that will be recruited in Qingshui and Waipu district Taichung City. Nursing homes will be randomly assigned to the experimental group and the comparison group. Each group has 20 subjects. The residents in experimental group will receive a low-resistance elastic band training(30 minutes), including warm-up and cold-down period, three times per week for 10 weeks. Residents in control group will receive regular activity in nursing home. Inclusion criteria for the elderly include: (1) living in nursing home over 3 months; (2) communicating with Mandarin and Taiwanese; (3) being able to sit in a chair or wheelchair; (4) can grip elastic band by hands; (5) no severe cardiovascular disease, musculoskeletal disorders and mental illness;(6) consciousness intact and their consent to participate in this study. Two structured questionnaires and an assessment checklist of muscle strength, flexibility will be used to collect data at baseline, week 8 and week 12 of exercise. The collected data will be coded and double checked and analyzed by using SPSS Window Release 20.0. The findings of this study can be apply to develop and conduct an effective exercise program through elastic band resistance training to improve residents' strength, flexibility, quality of life and care of ease in Taiwan.
Subjects undergoing bunionectomy often experience moderate to severe acute pain post-surgery. Normally such pain is controlled when subjects receive repeated doses of opioid analgesics. However, opioid therapy is commonly associated with side effects such as nausea, vomiting, sedation, constipation, addiction, tolerance, and respiratory depression. CG5503, a newly synthesized drug with an immediate release (IR) formulation, also acts as a centrally acting pain reliever but has a dual mode of action. The aim of this trial is to investigate the effectiveness (level of pain control) and safety (side effects) of CG5503 IR 75mg compared with no drug (placebo) or one dose of morphine (an opioid commonly used to treat post-surgical pain). This trial is a randomized, double-blind (neither investigator nor patient will know which treatment was received), active- and placebo-controlled, parallel-group, multicenter trial to evaluate the treatment of acute pain after bunionectomy. The trial will include a blinded 72 hour inpatient phase immediately following bunionectomy, during which subjects will be treated with either 75-mg CG5503 IR, a placebo, or 30-mg morphine, and pain relief will be periodically assessed. Assessments of pain relief include the pain intensity numeric rating scale (PI), pain relief numeric rating scale (PAR), and patient global impression of change scale (PGIC). Safety evaluations include monitoring of adverse events, physical examinations, and clinical laboratory tests. Venous blood samples will be collected for the determination of serum concentrations of CG5503 and morphine. The alternative trial hypothesis is that at least 1 dose strength of CG5503 will be different from placebo in controlling pain at 48 hours.
Dry, plied roll paper is transformed into hand wetted roll paper that may be used either dry, or selectively hand wetted using the device of the invention. The device is applied to the paper in liquid form, heated and cooled to form a plastic solid which becomes part of the paper. The device is then shaped into a container filled with an anti-bacterial cleaning agent, or other agent, and assembled on the paper between the top and bottom paper ply. The device is made on a modified roll-to-roll winding machine while the machine is in motion. This manufacturing method is more efficient than adding externally sourced batch-made wetting devices to paper. The hand wetted roll paper can be used as paper towels or toilet paper for dry and/or wet hygienic cleaning. The paper may have other properties depending on the agent used.
An oil base skin care composition including squalane and a method for treating skin are disclosed. The method includes the step of individually displaying a plurality of visual skin guides to a consumer having a plurality of visual representations of a categorical skin condition. Each of the visual representations correspond to a severity score for the categorical skin condition. The method further includes correlating the severity score to the consumer's current skin condition. At least two target skin conditions from the plurality of categorical skin conditions are determined in response to the severity scores for each of the categorical skin conditions. At least one booster containing at least one active ingredient is correlated for treating each target skin condition. A method for providing a customized skin care product to a customer and skin care kit is also disclosed.
FIELD: cosmetics. SUBSTANCE: invention relates to composition for keratin fibers, in part, hair oxidative staining containing 2-amino-3-hydroxypyridine as oxidizing dye-forming substance in suitable form and enzyme of laccase type. Invention relates also to method for staining using this composition and a kit for hair staining containing this composition. Invention provides uniform, chromatic and intense hair staining. EFFECT: valuable properties of composition. 26 cl, 2 tbl
OBJECTIVES: I. Compare unrelated donor bone marrow transplantation using T-cell-depleted marrow versus unmodified marrow in adults and children with leukemia. II. Evaluate 2-year leukemia-free survival, primary and secondary graft failure, graft-versus-host disease, infection, and relapse in these patients. III. Assess the quality of life associated with T-cell-depleted versus unmodified, unrelated donor transplantation.

OUTLINE: This is a randomized, multicenter study. Patients are stratified by center. Patients receive myeloablative therapy according to diagnosis: those with acute lymphocytic leukemia and lymphoblastic lymphoma are treated with total body irradiation (TBI), with a testicular and chest wall boost as appropriate, followed by cyclophosphamide (CTX); patients with undifferentiated or biphenotypic leukemia or with acute or chronic myelocytic leukemia are treated with CTX followed by TBI. Patients are then randomly assigned to receive non-T-cell-depleted, unrelated marrow versus T-cell-depleted, unrelated marrow. The modified marrow is depleted of T-lymphocytes by counterflow elutriation and positively selected for CD34 cells. Graft-versus-host disease (GVHD) prophylaxis with cyclosporine and methotrexate is given to the unmodified marrow group. Patients who receive modified marrow are given antithymocyte globulin (or methylprednisolone) for graft rejection prophylaxis before transplantation and cyclosporine and methylprednisolone for GVHD prophylaxis after transplantation.
The invention relates to a Chinese medicinal preparation for treating gastrointestinal diseases, and relates to a Chinese medicinal composition. The Chinese medicinal preparation solves the problems of single function, long administration period, nonideal curative effect and low cure rate in traditional Chinese medicines for treating the gastrointestinal diseases and also solves the problem that the traditional Chinese medicines cannot address both symptoms and root causes. The Chinese medicinal preparation is prepared from the following raw material medicaments: 5 to 10 parts of pearl, 15 to 20 parts of cinnabar, 10 to 15 parts of borneol, 10 to 15 parts of catechu, 10 to 15 parts of rhubarb, 20 to 25 parts of golden thread, 5 to 10 parts of villous amomum fruit and 25 to 35 parts of sea-ear shell in a weight ratio through mixing and pulverizing. The Chinese medicinal preparation has the rehabilitation functions of tranquilizing heart, harmonizing stomach, removing necrosis, detoxifying, nourishing internal organs, eliminating depression, supporting vital qi and curing injury, regulating human immunity and gastrointestinal mucosa, has the advantages of addressing both symptoms and root causes along with short administration period, quick response (the curative effect is effectual within one hour), excellent curative effect. The preparation is mainly suitable for treating esophagitis, superficial gastritis, bile regurgitational gastritis, gastric ulcer and duodenal ulcer. The cure rate of the preparation is over 95 percent.
The invention discloses a raw material composition of a cellulose and red alga polysaccharide plant empty capsule. The raw material composition of the cellulose and red alga polysaccharide plant empty capsule comprises the following raw materials in parts by weight: 77.5-98.5 parts of component A, 1.5-22.5 parts of red alga polysaccharide and 0.5-12.5 parts of alcohol, wherein the component A is a cellulose derivative or resin. The invention also discloses the cellulose and red alga polysaccharide plant empty capsule prepared from the raw material composition and a preparation method for the cellulose and red alga polysaccharide plant empty capsule. The plant empty capsule does not deform or crisp in an environment of high temperature, high humidity or cold, is low in moisture content and high in stability, and can be conveniently stored for a long time. Moreover, the requirements on the storage condition are low. Meanwhile, the plant empty capsule is stable in chemical property and has no cross-linking reaction or Maillard reaction or condensation reaction. Various physicochemical indexes of the plant empty capsule, such as disintegration time limit, completely accord with the specifications of the Chinese pharmacopoeia or national standard, and therefore, all defects and potential safety hazards of a gelatin capsule are completely eliminated. The industrial production of the cellulose and red alga polysaccharide plant empty capsule can be realized.
A clopidogrel 1,5-naphthalene disulfonate or pharmaceutical composition and formulation containing the disulfonate is provided to improve bioavailability and massively produce. A pharmaceutical composition comprises clopidogrel 1,5-naphthalene disulfonate of 50 % average particle diameter or solid dispersion containing the hydrate of the disulfonate and pharmaceutically allowable additive. The pharmaceutical composition further comprises fumaric acid, citric acid, tartaric acid, succinic acid, lactic acid, malic, tosyl acid, oxalic acid, succinic acid, ascorbic acid, glutamic acid, alginic acid, maleic acid, adipic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid or boric acid. The pharmaceutically allowable additive is lubricant or disintegrant. A solid dispersion additionally comprises water-insoluble inorganic carrier, surfactant, or antioxidant. The pharmaceutical formulation is used in a form of granule, tablet, or capsule.
PURPOSE: A composition containing morphinane alkaloids for anticancer or immunity enhancement is provided to suppress cancer cell proliferation and to induce cancer cell apoptosis. CONSTITUTION: A composition for anticancer or immunity enhancement contains morphinane alkaloids or pharmaceutically acceptable salt thereof as an active ingredient. Morphinane alkaloids is 6,7-di-Oacetylsinococuline: FK-3000. The compound is isolated and isolated from Stephania delavayi Diels using water or organic solvent. The organic solvent is methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, hexane, or cyclohexane. A drug for preventing or treating cancer contains morphinane alkaloids.
AIMS: Mapping progressive patterns of structural damage in epilepsies with idiopathic and secondarily generalized tonic-clonic seizures with causal structural covariance networks and multiple analysis strategies.
METHODS: Patients with idiopathic generalized tonic-clonic seizures (IGTCS) (n = 114) and secondarily generalized tonic-clonic seizures (SGTCS) (n = 125) were recruited. Morphometric parameter of gray matter volume was analyzed on structural MRI. Structural covariance network based on granger causality analysis (CaSCN) was performed on the cross-sectional morphometric data sorted by disease durations of patients. Seed-based CaSCN analysis was firstly carried out to map the progressive and influential patterns of damage to thalamus-related structures. A novel technique for voxel-based CaSCN density (CaSCNd) analysis was further proposed, enabling for identifying the epicenter of structural brain damage during the disease process.
RESULTS: The thalamus-associated CaSCNs demonstrated different patterns of progressive damage in two types of generalized tonic-clonic seizures. In IGTCS, the structural damage was predominantly driven from the thalamus, and expanded to the cortex, while in SGTCS, the damage was predominantly driven from the cortex, and expanded to the thalamus through the basal ganglia. CaSCNd analysis revealed that the IGTCS had an out-effect epicenter in the thalamus, whereas the SGTCS had equipotent in- and out-effects in the thalamus, cortex, and basal ganglia.
CONCLUSION: CaSCN revealed distinct damage patterns in the two types of GTCS, featuring with measurement of structural brain damage from the accumulating effect over a relatively long time period. Our work provided evidence for understanding network impairment mechanism underlying different GTCSs.
PURPOSE: Fetal intracranial hemorrhage is rarely identified in prenatal imaging. When identified, sparse data regarding neurodevelopmental outcomes worsens prenatal dilemmas. This MRI-based study aimed to assess prenatal characteristics and neurodevelopmental outcomes of fetal intracranial hemorrhage.
METHODS: A historical cohort study which identified fetal intracranial hemorrhage in 22 individual fetal MRI scans, as part of the assessment of abnormal prenatal sonographic findings. Severity was graded by the grading system commonly used in neonates, with modifications. Prenatal data was collected. Neurodevelopmental outcome was assessed clinically by Vineland-II Adaptive Behavior Scales.
RESULTS: Eight fetuses had intraventricular hemorrhage grade I-II, twelve had intraventricular hemorrhage grade III-IV, and two had infratentorial hemorrhage. The most prevalent risk factors were maternal chronic diseases and chronic use of medications. There was male predominance. Pregnancy was terminated in eleven cases. No surviving child who participated in the Vineland assessment had a grade IV hemorrhage. Vineland scores were normal in 9/11 children and moderately low in 2/11. The mean composite score of the cohort was not different from the mean score expected for age. Clinically, one child had hypotonia.
CONCLUSIONS: Prognosis for fetuses with ICH without parenchymal involvement is potentially more favorable than expected from the intraventricular hemorrhage grading-scale adopted from the preterm neonates. Parenchymal involvement may predict a worse outcome, but it is not the sole predicting feature. This information may be valuable during prenatal counseling.
The invention relates to a compound preparation for expelling in-vivo and in-vitro parasites from dogs and cats and a preparation method thereof. The compound preparation mainly comprises milbemycin oxime and praziquantel, wherein the milbemycin oxime is a novel and specific 16-membered ring macrolide medicament for preventing and controlling the in-vivo and in-vitro parasites of the dogs and the cats, which can specially prevent and control heartworms and efficiently prevent and control in-vivo parasites such as hookworms, roundworms, whipworms, belly worms and the like and in-vitro parasites such as hair follicle mites, scabies, louses, fleas and the like; and the praziquantel is effective to nematodes, trematodes and tapeworms in animal bodies. The milbemycin oxime and the praziquantel expel the parasites complementarily. The two medicaments are combined, so that a parasite expelling range is expanded and one-step parasite expelling effect is improved. The invention also provides a method for preparing compound tablets. The tablets prepared by the method can be released rapidly and dispersed fully.
The invention discloses a dihydropyrimidine compound, a preparation method and application thereof, and belongs to the technical field of pharmaceutical chemistry. The structure of the dihydropyrimidine compound is shown as formula I. The invention discloses a preparation method of the dihydropyrimidine compound. The invention also discloses a pharmaceutical preparation comprising the compound of formula I. The invention provides application of a compound shown in a formula I or a salt, a solvate, a allosteric isomer, a metabolite, a nitrogen oxide and a prodrug thereof in preparing a medicament for treating or preventing P2X3 and/or P2X2/3 receptor related diseases. The dihydropyrimidine compound has good affinity with P2X3 receptors, has strong antagonistic action on P2X3 receptors, and is safe and effective. Compared with the compound of the comparative example 1, the compound of the invention has obviously prolonged time of cough-relieving effect; compared with the positive medicament gefapixant, the in-vitro inhibition effect on the P2X3 receptor is stronger, and the taste of the mouse is not influenced.