anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Malnutrition is considered one of the major public health problems worldwide and negatively affects the growth, development and learning of schoolchildren. This study developed and evaluated a fermented milk drink with added Umbu (Spondias tuberosa) pulp in the weight gain and renutrition of mice submitted to malnutrition by calorie restriction, and in malnourished children. The supplementation with this fermented milk drink contributed to an increase of 7.2 % in body weight, and 64.3 % in albumin, and a reduction of 35 % in cholesterol in malnourished mice. In humans, a group of nine malnourished children consumed a daily 200 mL serving of the milk drink (for 60 days). For humans, the fermented milk drink allowed an increase of 16.5 % in body weight, and 20.9 % in body mass index in malnourished children. In conclusion, fermented milk drink has a positive effect on the re-nutrition of malnourished mice and helps to improve the nutritional status of malnourished children.
FIELD: medicine. SUBSTANCE: invention describes compounds of formula I: cyclo(A-B-C-D-Arg) wherein A is D-Val; B is L- or D-Phe; C is L-Asp, D-Asp of D-Asp (O-C 1 -C 4 -alkyl and D- Gly or Ala, at least two of amino acid residues being in D-form, and also salts thereof. Compounds act as integrine inhibitors and are useful for prophylaxis and treatment of diseases of blood circulation system and therapy of tumors. Present invention also describes method of preparing compounds of formula I, pharmaceutical compositions based on compounds and method of treatment of diseases associated with inhibiting integrine receptor ligand binding, using compounds of formula (I) in daily amount of 0.01-2 mg/body weight. EFFECT: more efficient treatment method. 7 cl, 3 ex, 1 tbl
The invention relates to a bone-strengthening tablet. The bone-strengthening tablet is a medicine for treating liver and kidney deficiency and discomfort in waist and knees, concretely is a Chinese patent medicine prepared by taking Chinese herbal medicines as raw materials, and is capable of treating osteoporosis. The invention also relates to a preparation method of the medicine. The bone-strengthening tablet is an oral table prepared by taking cornu cervi pantotrichum (removing hair), fructus psoraleae, cornu cervi degelatinatum, radix rehmanniae preparata, concha ostreae (calcined), radix dipsaci, radix ginseng rubra , radix angelicae sinensis, panax notoginseng, rhizoma atractylodis macrocephalae (fried), radix polygoni multiflori (processed), fructus corni, fructus lycii and pheretima as bulk drugs, and performing screening, drying and crushing on the raw materials through a provided tablet preparation technology. The provided formula is definite in therapeutic effect, and the tablet is an ideal medicine capable of rapidly treating osteoporosis. The tablet is simple in preparation method, easy to process and easy for large-scale production.
Patients who have an episode of Stage 2/3 AKI and are followed in a focused post-AKI clinic. Patients will be asked to continue on their regular diet and the protein and caloric ingestion will be recorded at each visit.
BACKGROUND: Posterior fossa surgery is commonly associated with severe postoperative pain. This study assessed the impact of ultrasound-guided greater occipital nerve (GON) block on postoperative pain and hemodynamic profiles in pediatric posterior fossa craniotomy.
MATERIALS AND METHODS: Children aged 2 to 12 years undergoing elective posterior fossa craniotomy with general anesthesia were randomly allocated to a control group receiving standard care (n=18) or a GON block group receiving standard care plus bilateral ultrasound-guided GON block (=17). Outcomes were postoperative pain assessed using the objective pain scale, time to first postoperative analgesia, intraoperative fentanyl consumption, perioperative blood pressure and heart rate, incidence of nausea and vomiting, and nerve-block-related complications.
RESULTS: Objective pain scale scores were lower in the GON block group than in the control group at 2, 4, 6, 8 (all P =0.0001), 12 ( P =0.001), 16 ( P =0.03), and 24-hour ( P =0.004) postoperatively. The time to first analgesic request was 13.4±7.4 hours in the GON block group and 1.8±1.5 hours in the control group ( P <0.001). Intraoperative fentanyl consumption was 2.68±0.53 μg/kg -1 in the GON block group and 4.1±0.53 μg/kg -1 in the control group ( P =0.0001). Systolic blood pressure was lower in the GON block group at several intraoperative and postoperative time points, whereas heart rate was similar in the two groups at most time points. The incidence of postoperative nausea and vomiting was similar between groups ( P =0.38), and there were no nerve-block-related complications.
CONCLUSIONS: In children undergoing posterior fossa craniotomy, GON block was associated with superior quality and duration of postoperative analgesia and better hemodynamic profile compared with standard care.
The invention discloses a measure method of photocatalysis nanometer active water and the application thereof. Establishing and improving the concept of free radicals. In order to provide scientific basis for the photocatalysis nanometer active water which can secure or prevent AIDS, human avian influenza, SARS, hepatitis b, leukemia, lupus erythematosus, cancer, other major diseases and other various kinds of diseases. Measuring free radical active ability in photocatalysis nanometer activity with chemical analysis and physical colorimetry method, destructivity of protein oxygenolysis to body protein of bacterial and virus, and providing scientific basis of organic nutrients on which bacterial and virus are survived and multiplied; measuring free radicals in human body fluid and animal body fluid to establish free radical standard of human body and animal body and artificial immunity system, for preventing epidemic situation, and providing scientific basis for medical healthcare. Using photocatalysis nanometer active water in production of industry and agriculture, medical healthcare, food preservation, plant protection, water treatment, breeding and seedling, and other fields for providing scientific basis. The invention is easy to operate, the cost is low, and the invention is scientific and reliable.
The infants will be divided into 200 in the control group. Eligible hospitalized preterm infants that met the inclusion criteria from January 2017 to December 2019 were selected for the control group by retrospective cohort.
Adolescents with anorexia nervosa (AN) are at high risk for low bone mineral density at a time when healthy adolescents are rapidly accruing bone, with implications for peak bone mass and fracture risk in later life. They are also deficient in insulin-like growth factor I (IGF-I), the bone trophic factor made in the liver in response to growth hormone (GH), despite elevated levels GH. It is possible that deficiency of IGF-I, a hormone very important for the maintenance of skeletal integrity, may contribute to the severe osteopenia seen in AN. The physiologic effects of rhIGF-I treatment in adolescents with AN had not been studied. The goal of this proposal was to investigate the acute effects of rhIGF-I on bone metabolism in adolescent girls with AN.

Specific Aim: It was hypothesized that adolescent AN patients, being IGF-I deficient, would respond to exogenously administered rhIGF-I with elevations in biochemical indices of bone turnover. Therefore, rhIGF-I was administered to AN patients by subcutaneous injection over 10 days with concomitant measurement of indices of bone turnover, and calcium regulatory hormones.
Participants will be instructed to use nicotine patches and gradually reduce the number of regular nicotine content cigarettes that they smoke throughout the study period. They will receive regular nicotine content cigarettes (16.5 mg/g) throughout the study study period. After establishing a baseline CPD during week 1, participants will receive 70% of their baseline CPD during week 2, 35% during week 3, 15% during week 4, and 3% during week 5. Participants will receive a minimum of 1 CPD during week 5.
Women will be randomly divided into two groups; one will be subjected to endometrial preparation by hormone replacement therapy (HRT) and the other will be subjected to minimal ovarian stimulation (MOS). Women in the HRT group will be given estradiol valerate 4 mg daily from day 2 to day 12 of the cycle then the endometrial thickness will be assessed on day 13 by transvaginal sonography (TVS). If the endometrium is ≥ 8 mm and of moderate echogenicity, luteal phase support (using progesterone supplements) will be started but if the endometrium is \< 8 mm, estradiol valerate will be continued until reaching appropriate endometrial thickness and echogenicity then the luteal phase support will be started. Women in the MOS group will be given clomiphene citrate in dose of 100-150 mg daily for 5 days (from day 2 to day 6 of the cycle) then switched to low dose gonadotropin (75-150 IU daily) followed by monitoring of the follicular growth (folliculometry) ); starting from day 10 of the stimulation cycle and repeated every 2 days. Final oocyte maturation will be induced by administration of human chorionic gonadotropin (HCG) when there will be at least one leading follicle \> 18 mm in diameter followed by luteal phase support (using progesterone supplements) after 48 hours. In both groups, FET will be planned in the appropriate day according to the stage that the embryos have been cryopreserved in it.
Inflammatory bowel disease (IBD) is a condition characterized by inflammation in the gastrointestinal tract. Reducing intestinal inflammation is a promising approach for treating IBD. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome, a critical component of the innate immune system, is implicated in the pathogenesis of IBD. Therefore, inhibiting NLRP3 inflammasome activation is a potential therapeutic strategy for IBD. In this study, we investigated the effects of the interleukin-5 (IL-5) receptor antagonist YM-90709 on dextran sulfate sodium-induced experimental colitis in mice. We found that YM-90709 reduced the expressions of IL-1β and caspase-1 p20 in the colon and ameliorated colitis. Furthermore, we identified YM-90709 as an effective agent for inhibiting NLRP3 inflammasome activation. Knockdown of IL-5 receptor or using an inhibitor of STAT5, a key transcription factor downstream of the IL-5/IL-5 receptor signal pathway, also reduced NLRP3 inflammasome-dependent IL-1β release and ASC speck formation. Our study is the first to demonstrate that the NLRP3 inflammasome may be a downstream signal of IL-5/IL-5 receptor and that YM-90709 protects against IBD by inhibiting IL-5 receptor. These findings suggest a new strategy for regulating intestinal inflammation and managing IBD.
Patients were randomly assigned to Metoprolol Group. The drug was dispensed in 60ml \& 5ml syringes of 0.9% NaCl and 1mg/ml Metoprolol. Investigators and patients were blinded to the group assignment.
The invention discloses a preparing method for common leafflower herb oral solid preparation and its application. The effective components of the common leafflower herb are extracted by three solventwith different polarity of n-hexane, ethanol and water. Then the main medicine is obtained by refining respective extracting parts and combinating obtained effective part group. The invention adds some proper medical accessory to produce the common leafflower herb oral solid preparation which has a stronger antivirus function and repairing liver injury function. The invention fully extracts the effective components of the common leafflower herb, has a low cost and low pollution and is suitable for industry production. Pharmacological experiments prove the inventive common leafflower herb oralsolid preparation has a good hepatitis B virus resistance function.
NEW MATERIAL:A compound shown by the formula I [R is 1-4C alkylene, vinylene, or group shown by the formula II(X is H, or lower alkyl)] and its salt. EXAMPLE:A 5beta-(3-carboxypropionyloxy)derivative of milbemycin D. USE:An acaricide. An insecticide. Showing acaricidal activity especially against Tetranychus, Ixodidae, Dermanysside, and improved insecticidal activity against noxious insects such as flies, lice, cockroaches, etc. and nematodes, etc. PROCESS:A compound shown by the formula III is reacted with a compound shown by the formula IV in an inert solvent such as n-hexane, ethyl ether, chloroform, etc. in the presence of a base (e.g., triethylamine, pyridine, etc.) at 0-50 deg.C to give a compound shown by the formula I . Milbemycin D shown by the formula III as the starting substance is obtained from a culture of B-41-146 strain belonging to the genus Streptomyces.
Ulcerative colitis is a non-specific chronic inflammation of gut characterized by referral bloody stool, diarrhea and abdominal pain. Endoscopic features of the disease severity and mucosal healing stage are strongly associated with treatment response and prognosis in the future. Currently, the Mayo endoscopic sub-score (Mayo ES) and Ulcerative colitis endoscopic index of severity (UCEIS) are commonly recommended to guide therapeutic adjustments. However, the accuracy of these scales greatly relies on intra-observer and inter-observer consistency for lack of objective measurements. Recently, deep learning algorithm based on convolutional neural network (CNN) has shown multiple potential in computer-aided detection and computer-aided diagnose of gastrointestinal lesions. Up to now, no randomized controlled trials have been conducted to evaluate the performance of deep learning algorithm for assessing disease activity in ulcerative colitis. This study aims to train a deep learnig algorithm to assess severity and mucosal healing stage of ulcerative colitis using the Mayo ES and UCEIS scale, then testify whether the engagement of AI can improve the evaluation accuracy of physicians in a multi-center clinical practice.
Plasma exchange (PE) and immunoadsorption (IA) are first- or second line treatment options in patients with neurological autoimmune disease, including multiple sclerosis, neuromyelitis optica, chronic inflammatory demyelinating polyneuropathy, acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré-Syndrom) or autoimmune encephalitis. This prospective controlled monocentric observational study of patients treated with either tryptophan IA or PE in cases of autoimmune neurological therapy refractory disease was performed between 2016 and 2019. The main outcome parameter for efficiency was clinical improvement after completion of treatment with PE/IA. Symptoms were assessed before the first and after the last IA/PE. In total, all patients receive 5 treatments. As patients with various neurological autoimmune diseases were included in the study, the overall treatment response was categorized descriptively as improvement or no improvement of symptoms.
The invention provides a microparticle comprising a mixture of a biodegradable polymer and a water soluble polymer, and an active agent. Preferred biodegradable polymers are lactide homopolymers or copolymers of lactide and glycolide. Preferred water soluble polymers are PEG (poly(ethylene glycol)) or PEG copolymers. The particles exhibit a linear release profile of active agent. The invention also provides an emulsion/solvent extraction method to make the microparticles. The continuous phase of the secondary emulsion contains an organic solvent which is miscible with the organic solvent in the primary emulsion.
The application provides a virus envelope protein assembly system, a preparation method and application thereof. The envelope protein assembly system comprises a secretory peptide signal sequence, an exogenous assembly target protein molecule and a transmembrane region (TM) which are connected in sequence. The method is that gene synthesis technology is utilized to integrate multiple components containing secretory peptide signal sequence, exogenous assembly target protein molecule and transmembrane region into gene expression vector, transfect cell, and infect cell with virus. The scheme of the application can be used for modifying candidate vectors of oncolytic viruses or viral vaccines, and the capsular protein assembly system can be correctly assembled on the surfaces of viruses. After the target protein molecules are assembled by the viral envelope through exogenous assembly, the application route and the application of the recombinant virus are more expanded. In addition, the method does not need to carry out complicated internal editing and transformation on the virus genes, and has simple preparation method and wide application range.
A composition and method for treating both superficial and subdermal inflammation is taught by treating an inflamed skin area, muscle, or bone joint, with a therapeutically effective amount of a skin-compatible ester of a zwitterionic aminosulphonic acid (ZASA-Ester) of the formula. wherein M is an alkali metal, like sodium, and R is a naturally occurring, straight-chain, saturated or unsaturated, aliphatic acid, the esters of which form fatty acids in nature. The most useful of which are the acetic oleic (cis isomer), linoleic, palmitic, and stearic moieties; they occur naturally as glycerides, i.e., esters of glycerol. Also useful are analogs of HEPES like piperazine-N'-(2-ethane sulfonic acid); N-methylpiperazine-N'-(2-ethane sulfonic acid);, and the piperiodine analog of the piperazine ester. A pharmacologic composition is also provided which comprises at least one amphoteric (Zwitterionic-ester) with a pharmacologically-acceptable topical carrier or base. Other adjunctive pharmaceutical agents may be included to facilitate other than topical administration. Also useful are analogs of HEPES, like Piperazine-N1(2-ethanesulfonic acid; N-Methylpiperazine-N1(2-ethanesulfonic acid) and the piperidine analog of the piperazine ester.
Scalp stimulation during sleep (study PART B) - bilateral electrode pairs placed on the upper forehead near the midline (F3 and F4) and adjacent to the ear in the mastoid region (M1 and M2). Group 5 will receive scalp stimulation at 0.75 Hz with a modified alternating current (AC) waveform during sleep.
BACKGROUND: Cerebral visual impairment (CVI) is a common sequala of early brain injury, damage, or malformation and is one of the leading individual causes of visual dysfunction in pediatric populations worldwide. Although patients with CVI are heterogeneous both in terms of underlying etiology and visual behavioural manifestations, there may be underlying similarities in terms of which white matter pathways are potentially altered. This exploratory study used diffusion tractography to examine potential differences in volume, quantitative anisotropy (QA), as well as mean, axial, and radial diffusivities (mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), respectively) focusing on the dorsal and ventral visual stream pathways in a cohort of young adults with CVI compared to typically sighted and developing controls.
METHODS: High angular resolution diffusion imaging (HARDI) data were acquired in a sample of 10 individuals with a diagnosis of CVI (mean age = 17.3 years, 2.97 standard deviation (SD), range 14-22 years) and 17 controls (mean age = 19.82 years, 3.34 SD, range 15-25 years). The inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF), vertical occipital fasciculus (VOF), and the three divisions of the superior longitudinal fasciculus (SLF I, II, and III) were virtually reconstructed and average tract volume (adjusted for intracranial volume), MD, AD, and RD were compared between CVI and control groups. As a secondary analysis, an analysis of variance (ANOVA) was carried out to investigate potential differences based on etiology (i.e., CVI due to periventricular leukomalacia (CVI-PVL) and CVI due to other causes (CVI-nonPVL)).
RESULTS: We observed a large degree of variation within the CVI group, which minimized the overall group differences in tractography outcomes when examining the CVI sample as a unitary group. In our secondary analysis, we observed significant reductions in tract volume in the CVI-PVL group compared to both controls and individuals with CVI due to other causes. We also observed widespread significant increases in QA, MD, and AD in CVI-PVL compared to the control group, with mixed effects in the CVI-nonPVL group.
CONCLUSIONS: These data provide preliminary evidence for aberrant development of key white matter fasciculi implicated in visual perceptual processing skills, which are often impaired to varying degrees in individuals with CVI. The results also indicate that the severity and extent of the white matter changes may be due in part to the underlying cause of the cerebral visual impairments. Additional analyses will need to be done in a larger sample alongside behavioural testing to fully appreciate the relationships between white matter integrity, visual dysfunction, and associated causes in individuals with CVI.
BACKGROUND: Altered neural haemodynamic activity during decision making and learning has been linked to the effects of inflammation on mood and motivated behaviours. So far, it has been reported that blunted mesolimbic dopamine reward signals are associated with inflammation-induced anhedonia and apathy. Nonetheless, it is still unclear whether inflammation impacts neural activity underpinning decision dynamics. The process of decision making involves integration of noisy evidence from the environment until a critical threshold of evidence is reached. There is growing empirical evidence that such process, which is usually referred to as bounded accumulation of decision evidence, is affected in the context of mental illness.
METHODS: In a randomised, placebo-controlled, crossover study, 19 healthy male participants were allocated to placebo and typhoid vaccination. Three to four hours post-injection, participants performed a probabilistic reversal-learning task during functional magnetic resonance imaging. To capture the hidden neurocognitive operations underpinning decision-making, we devised a hybrid sequential sampling and reinforcement learning computational model. We conducted whole brain analyses informed by the modelling results to investigate the effects of inflammation on the efficiency of decision dynamics and reward learning.
RESULTS: We found that during the decision phase of the task, typhoid vaccination attenuated neural signatures of bounded evidence accumulation in the dorsomedial prefrontal cortex, only for decisions requiring short integration time. Consistent with prior work, we showed that, in the outcome phase, mild acute inflammation blunted the reward prediction error in the bilateral ventral striatum and amygdala.
CONCLUSIONS: Our study extends current insights into the effects of inflammation on the neural mechanisms of decision making and shows that exogenous inflammation alters neural activity indexing efficiency of evidence integration, as a function of choice discriminability. Moreover, we replicate previous findings that inflammation blunts striatal reward prediction error signals.
Patients receive adenosine perfusion CMR for functional testing, first. The examination is conducted on a 3.0 Tesla whole-body scanner with a 32-channel phased-array cardiac receiver coil according to a well-established standard protocol \[21-23\]. In case reversible ischemia can be detected, subjects are sent to coronary angiography and PCI afterwards.