anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Peritoneal metastasis is the common route of metastasis in gastric cancer and is a major cause of death in advanced gastric cancer. Early intervention with comprehensive treatment can effectively improve the prognosis of some patients with peritoneal metastasis. However, early peritoneal metastasis in gastric cancer is predominantly micro-metastasis, which cannot be effectively evaluated by imaging studies. Moreover, the detection of disseminated cancer cells in peritoneal lavage suffers from a low detection rate and significant heterogeneity. In recent years, the development and application of new liquid biopsy technologies such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have provided new means to assess potential peritoneal metastasis at the cellular and molecular levels, gradually becoming research hotspots in this field. This review will summarize the relevant progress of liquid biopsy in peritoneal metastasis, which holds significant importance for improving the prognosis of gastric cancer patients in China.
Provided are a stable AST-3424 API product, a preparation method therefor, and storage thereof. The stable AST-3424 API product provided in the present invention is a solution of AST-3424 in ethanol, and the mass percentage of AST-3424 in the solution is 30%-40%. Also provided is a packaging unit of the product, which comprises a container and a stable AST-3424 API product contained in the container. The container is provided with a container body used for containing the product and a sealing structure used for sealing the container body. The container body and the sealing structure are both made from a medicinal-grade high-density polyethylene material. An oily AST-3424 product obtained after separation and purification is mixed with absolute ethyl alcohol at no more than 30 °C, and then distilled under reduced pressure until the mass percentage of AST-3424 reaches a preset value to obtain the product. The described product should be stored in a dark environment at -20 ± 5 °C.
Late onset Alzheimer's disease (AD) is a progressive neurodegenerative disease, with brain changes beginning years before symptoms surface. AD is characterized by neuronal loss, the classic feature of the disease that underlies brain atrophy. However, GWAS reports and recent single-nucleus RNA sequencing (snRNA-seq) efforts have highlighted that glial cells, particularly microglia, claim a central role in AD pathophysiology. Here, we tailor pattern-learning algorithms to explore distinct gene programs by integrating the entire transcriptome, yielding distributed AD-predictive modules within the brain's major cell-types. We show that these learned modules are biologically meaningful through the identification of new and relevant enriched signaling cascades. The predictive nature of our modules, especially in microglia, allows us to infer each subject's progression along a disease pseudo-trajectory, confirmed by post-mortem pathological brain tissue markers. Additionally, we quantify the interplay between pairs of cell-type modules in the AD brain, and localized known AD risk genes to enriched module gene programs. Our collective findings advocate for a transition from cell-type-specificity to gene modules specificity to unlock the potential of unique gene programs, recasting the roles of recently reported genome-wide AD risk loci.
PURPOSE:To obtain a new compound having excellent K<+> channel action activity and useful as a medicine. CONSTITUTION:A compound of formula I [R1 is H, a halogen, etc.; R2 is O or S; R3 is NR4R5 or OR6 (R4 to R6 each is H or a lower alcohol), e.g. 2,2-bis(trifluoromethyl)-N-methyl-6-nitro-2H-1-benzopyrane-carbamide. The compound is obtained by reacting, e.g. a compound of formula II such as 5-nitro-2- fluoroacetophenone with hexafluoroacetone in an inert solvent such as benzene in the presence of a base such as pyrrolidine at 50-90 deg.C to afford a compound of formula III, introducing a halogen or an eliminating group into the 4-position of the compound by an ordinary method, reacting the resultant compound with carbon monoxide in an inert solvent such as THF in the presence of a zero- valent or a divalent Pd catalyst at 0-130 deg.C to afford a compound of formula IV (R7 is H or a lower alkyl) and successively subjecting the compound of compound IV to amidation reaction, thioamidation reaction, etc.
BACKGROUND: Shoulder pain is a condition that seriously discomforts patients and develops caused by a peritoneal tear in laparoscopic extraperitoneal hernia repair (TEP) surgeries. Although surgeons generally prefer general anesthesia for the TEP technique, many studies have been carried out on the use of regional anesthesia in recent years. In our study, we aimed to investigate the efficacy and safety of the combined spinal/epidural anesthesia (CSEA) method to prevent shoulder pain in the TEP technique.
METHODS: The patients who operated with the TEP procedure were divided into 2 groups; SA (group 1) and CSEA (group 2). The 2 patient groups were compared in terms of sex, age, body mass index, duration of surgery, total operation time, patient satisfaction, pain scores, length of hospital stay, adverse effects, intraoperative, and postoperative complications.
RESULTS: The number of patients in group 1 was 42 and group 2 was 40. The mean operation time was recorded as 55.9 and 80.2 minutes in groups 1 and 2, respectively, which was statistically significantly shorter in group 1 ( P <0.001). Postoperative pain was significantly less in group 2 for the 4th hour ( P <0.0001) and the 12th hour ( P =0.047). There was no difference between the 2 groups in terms of peritoneal tear ( P =0.860). Intraoperative and postoperative shoulder pain was significantly less in group 2 ( P =0.038, P =0015, respectively).
CONCLUSION: CSEA is an effective and safe anesthesia method for preventing shoulder pain that develops after TEP surgeries.
The invention relates to the technical field of traditional Chinese medicines and provides a traditional Chinese medicine composition for preventing pneumonia according to the pneumonia understanding mechanism of the traditional Chinese medicine. The traditional Chinese medicine composition is composed of 30-50 parts by weight of gypsum, 4-8 parts by weight of herba ephedra, 6-10 parts by weight of licorice root, 8-12 parts by weight of lumbricus, 7-11 parts by weight of stiff silkworm and 10-20 parts by weight of giant knotweed rhizome. The traditional Chinese medicine composition is decocted and one dosage of the decoction is taken every day. One treatment course comprises seven days. The traditional Chinese medicine composition utilizes raw materials easy to obtain, has good curative effects and has no side effect. The statistics results of tests on hundreds of pneumonia patients show that the traditional Chinese medicine composition has an effective rate of 95% or more.
A computerized system and method to allow patient to control and provide a safe, secure and efficient real-time access to the patient's private health records (PHR) stored in the encrypted uniform format in a Private Health Vault (PHV) database. The system utilizes patient's private encryption key for encrypting and decrypting PHR stored in the PHV. The patient (or patient's appointed agent) controls access to the PHR and authorizes by electronic communications with the PHV server to allow doctors to have access to the centrally maintained and structured medical data in the PHV. The access can be limited in duration.The patient's private keys may be stored in a remote Key Bank database, separately form the PHV database, and the location of the patient's PHV data may also require transmission of the location id from a separate Mapping server. Additional security is provided by determining digital proximity of the doctor's and patient's mobile devices to the node device in the doctor's office, and terminating access upon set condition. It also utilizes 2-way digital token or id exchange and confirmation between the patent and doctor, as well as digital authentication for access and identity verification. The centralized PHV stores patient data more efficiently and prevents unauthorized use of the patient data by separating the key(s) needed to decrypt patient data from the actual patient records in the PHV.
Dietary supplement: Berry peel drink Subjects are asked to consume 150 ml experimental drink containing a berry peel fruit powder. In addition, on days-1 and 28, subjects will receive an acute challenge of test drink at our clinical facility. After 30 min. berry drink intake, subjects will be given standardized breakfast corresponding to 50 g available carbohydrates.
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by the immune-mediated destruction of small and medium intrahepatic bile ducts, with variable outcomes and progression. This review summarises the state of the art regarding the risk of neoplastic progression in PBC patients, with a particular focus on the molecular alterations present in PBC and in hepatocellular carcinoma (HCC), which is the most frequent liver cancer in these patients. Major risk factors are male gender, viral infections, e.g., HBV and HCV, non-response to UDCA, and high alcohol intake, as well as some metabolic-associated factors. Overall, HCC development is significantly more frequent in patients with advanced histological stages, being related to liver cirrhosis. It seems to be of fundamental importance to unravel eventual dysfunctional molecular pathways in PBC patients that may be used as biomarkers for HCC development. In the near future, this will possibly take advantage of artificial intelligence-designed algorithms.
Sexual minorities (SMs; e.g., lesbian, gay, bisexual, and other non-heterosexual individuals) are more likely to be current alcohol drinkers than their heterosexual peers while separately experiencing elevated inflammation. Yet, little research has assessed the association between alcohol use and inflammation among subgroups of SMs, let alone potential differences among people with multiple marginal identities (e.g., race/ethnicity and sexual identity). Data came from the National Health and Nutrition Survey 2015-2016. Survey-weighted multivariable linear regression analysis was used to assess the relationship between alcohol use categories, heavy episodic drinking, and log-CRP (C-reactive protein). Models were stratified by sexual identity to determine whether associations between alcohol use and inflammation or between race/ethnicity and inflammation differed by sexual identity. Among 3220 participants, 1000 (36.8%) reported light alcohol use, 870 (32.0%) reported moderate use, and 483 (17.8%) reported heavy use. Mean raw CRP was 4.1 mg/L (SD = 8.1). The association between race/ethnicity and CRP differed in stratified relative to non-stratified models with key differences in CRP among individuals with multiple marginalized identities. We also observed that while the "classic" J-shaped relationship between alcohol use and systemic inflammation persists among heterosexuals in this sample, it does not hold among subgroups of sexual minorities. In particular, bisexuals who report heavy alcohol use, compared to non-users, experience significantly elevated CRP. Finally, we did not observe any association between heavy episodic drinking and CRP among subgroups of sexual minorities. Future studies assessing alcohol and biomarker data need to strive to include subgroups of sexual minorities and people with multiple marginal identities to better target behavioral and biomedical interventions aimed at reducing health disparities.
We report the first case of relapsing anti-GBM disease secondary to alemtuzumab in a 24-year-old female with relapsing-remitting multiple sclerosis. Initial anti-GBM disease was detected 10 months after alemtuzumab was given and was diagnosed by demonstrating high anti-GBM antibody titers and with a confirmatory kidney biopsy. The patient presented with a rapidly progressive glomerulonephritis with no pulmonary involvement. After appropriate treatment, the patient went into remission with undetectable anti-GBM antibodies. However, 20 months later, the patient re-presented with relapsing anti-GBM disease. Despite aggressive treatment, the patient became dialysis-dependent.
Forty patients who chose our hospital for intravenous infusion were included in the study. Randomly divide two groups using the numerical table method.Control group, 20 cases, receiving routine nursing care.Observation group, 20 cases, receiving humanized care.

Control group: Routine nursing, strict implementation of the "three checks and eight pairs" process, strict inspection of the quality of drugs used by patients, and strict adherence to medical advice on drug dosage.

Observation group: Humanized nursing includes humanized environmental care, humanized medical guidance, humanized psychological care, and humanized standardized management of IVGTT treatment process. The specific content is: (1) Humanized environmental care: Increase the frequency of cleaning the ward. If there is vomit or stagnant water, it should be removed as soon as possible to ensure that the ward floor is always kept clean and tidy, and to avoid patients falling due to water stains or foreign objects on the floor. Reasonably increase the number of garbage bins in the ward area. If conditions permit, place magazines, educational manuals, and other items in the ward that can help patients pass the time during the infusion process. (2) Humanized medical guidance: In addition to inquiring about the patient's allergy history and explaining the effects of medication before infusion, explain possible adverse reactions and corresponding treatment measures to the patient to avoid confusion, negative emotions or psychology after adverse reactions occur. If the patient does not have good vascular conditions, nursing staff can help massage the venous area before puncture, if the condition allows. Inform patients to pay attention to any adverse events (such as slipping of infusion set, redness and swelling of puncture site, etc.) during infusion, and immediately notify nursing staff if any are found. (3) Humanized psychological nursing: Many patients resist venipuncture, and nursing staff need to provide health education before IVGTT, so that patients understand the necessity and safety of IVGTT, improve patient cooperation, actively communicate with patients, understand their concerns about IVGTT, and provide timely and correct guidance; Remind family members to care for and encourage patients, so that they can actively cooperate with IVGTT. (4) Humanized and standardized management of IVGTT treatment process: One of the core tasks of nursing work is IVGTT. We strictly follow the hospital's nursing system for IVGTT treatment, strengthen training for nursing staff in terms of service attitude, social skills, puncture skills, etc., comprehensively improve the personal comprehensive literacy of nursing staff, and ensure that all nursing staff can perform venous puncture in a standardized and efficient manner.
OBJECTIVE: 1. To survey how vocal fatigue manifests itself in the vocal range of a sample of professional, female opera singers. 2. To assess laryngeal videostroboscopic changes of one professional, female opera singer before and after extended operatic singing.
METHODS: Survey study: 296 professional, female opera singers were recruited to participate in an anonymous research survey querying the temporary impact of vocal fatigue in professional, female opera singers. 46.3% of participants described themselves as singing mainstage roles at large, A-level opera houses. Singers were asked to report where in their vocal range they experienced the effects of vocal fatigue and could choose more than one response. Single-subject study: One professional, female opera singer (the author) underwent two laryngeal videostroboscopic exams pre and post vocal loading. The exams were evaluated and compared independently by two blinded laryngologists.
RESULTS: The results of the survey found that 42.9% of the total responses from professional, female opera singers indicated a temporary impact on the lower middle range (≈C4-F4) as a result of vocal fatigue. 36.5% of participants experienced a temporary impact on their lowest range (≈below C4) and 19.6% reported a temporary impact on their higher range due to vocal fatigue. The results of the single-subject study showed reduced glottal closure pattern in the postloading, lower middle range, head voice condition.
CONCLUSIONS: A large proportion (64.9%) of the professional, female opera singers surveyed reported increased difficulty navigating their lower middle range and/or lowest range after extended operatic singing. These results support the single-subject study, which found that after vocal loading, there was a decrease in glottal competence while singing in head voice in the lower middle range.
Healthy adult subjects will be prospectively assigned to 1 of 4 cohorts. Within each cohort, 8 subjects will be randomized in a 3:1 ratio (6 active + 2 placebo) per cohort to receive TS-134 or placebo as a single oral dose solution. All cohorts will be dosed in a fasted state except for the 2nd and 4th (food effect) cohorts, which will be dosed first in a fasted state, and then in a fed state, in a single crossover design conducted with a washout between two periods. In the 3rd (CSF) cohort, 8 subjects will receive one dose level of TS-134 as a single-blind dosing assignment; there will be no placebo dosing.
FIELD: cosmetology.SUBSTANCE: present invention relates to the field of cosmetology and discloses an emulsified liposomal composition and a method for its preparation. The emulsified liposome composition includes a phospholipid stably encapsulating the active ingredient. The phospholipid included in the composition contains phosphatidylethanolamine and phosphatidylcholine, with a mass ratio of phosphatidylethanolamine to phosphatidylcholine of 3-6: 1. The liposome is homogenized to particles with a diameter of 10 nm to 1000 nm. The emulsified liposome composition is intended to promote penetration and absorption of the active ingredient. According to the method of obtaining a liposomal composition, the following components are used: butane-1,3-diol, hydroxyacetophenone, hexane-1,6-diol, glycerin, xanthan gum, hydrolyzed sclerotium gum, water, active ingredient and lecithin. The present invention makes it possible to obtain liposomes capable of penetrating into the deep layers of the skin quickly and deeply.EFFECT: due to the moisturizing or antioxidant active ingredient encapsulated in the emulsified liposome composition, the emulsified liposome composition has a moisturizing and antioxidant effect on the skin and can be widely used in care, makeup and sun protection products.9 cl, 10 dwg, 2 tbl, 8 ex
Once consented and registered, eligible patients will commence Cycle 1 and be assessed on Cycle 1 Day 1. An entire cycle will be 28 days of continuous Tofacitinib dosing. There will be a gap of 18-24 days between the first and subsequent cycles of treatment. The patient will once again be assessed on Cycle 2 Day 1. An interim follow-up will be done after the second cycle, during which the patient will undergo a brain MRI for tumor measurements along with all other assessments. Subsequent cycles will continue as prior, with subject assessments, brain MRI, and toxicity evaluations every 4 weeks. Treatments will stop upon evidence of disease progression, unacceptable toxicity, or if the physician deems it unsafe for the subject to continue in the study.
PURPOSE: Anastomotic recurrence leads to poor prognosis in patients with Siewert II or III adenocarcinoma who undergo radical gastrectomy and do not receive neoadjuvant therapy. We aimed to establish a prognostic model to evaluate the risk of postoperative anastomotic recurrence in patients with Siewert II or III adenocarcinoma who did not receive neoadjuvant therapy.
METHODS: We included 366 patients with Siewert II or III adenocarcinoma who were treated with radical gastrectomy without neoadjuvant therapy at Fujian Provincial Hospital (FPH) between 2012 and 2018 as the development cohort. Cox regression was used to verify prognostic factors for anastomotic recurrence, and a nomogram was established. The nomogram was externally validated using a combined cohort of two external centers. Patients were classified into high- or low-risk groups according to the diagnostic threshold and nomogram scores, and recurrence-related survival analysis was analyzed.
RESULTS: The average age was 64.6 years, and 285 patients were male. All surgeries were successfully performed (185 open vs 181 laparoscopic). The 3-year anastomotic recurrence rate was significantly lower in the low-risk group (3.5% vs 18.8%, P < 0.001). The predictive performance was verified in the external validation cohort. This model better stratified patient survival than the American Joint Committee on Cancer (AJCC) TNM staging system.
CONCLUSIONS: This novel nomogram with surgical margin, postoperative tumor node metastasis (pTNM) stage, and neural invasion as prognostic factors has a significant predictive performance for the risk of anastomotic recurrence after radical gastrectomy in patients with Siewert II or III adenocarcinoma.
Atherosclerosis imposes a heavy burden on cardiovascular health due to its indispensable role in the pathogenesis of cardiovascular disease (CVD) such as coronary artery disease and heart failure. Ample clinical and experimental evidence has corroborated the vital role of inflammation in the pathophysiology of atherosclerosis. Hence, the demand for preclinical research into atherosclerotic inflammation is on the horizon. Indeed, the acquisition of an in-depth knowledge of the molecular and cellular mechanisms of inflammation in atherosclerosis should allow us to identify novel therapeutic targets with translational merits. In this review, we aimed to critically discuss and speculate on the recently identified molecular and cellular mechanisms of inflammation in atherosclerosis. Moreover, we delineated various signaling cascades and proinflammatory responses in macrophages and other leukocytes that promote plaque inflammation and atherosclerosis. In the end, we highlighted potential therapeutic targets, the pros and cons of current interventions, as well as anti-inflammatory and atheroprotective mechanisms.
Methods and analyses: The aim of this study is to recruit 80 children and to randomize them either to an intervention group or a control group with standard care. Intervention group receive intensive, family-based diet and physical activity counseling, deliver by a multidisciplinary team of a pediatrician, a nurse and a clinical nutritionist. Control group do not receive any lifestyle intervention during the study. The inclusion criteria are weight-for-height ≥+40% or ≥+30% and increasing and age of 6-12 years. All participants fill out the study questionnaires and plasma samples are taken at baseline and at 12 months. Outcome variables will be compared between intervention and control groups.