anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a skin external preparation capable of suppressing production of peroxide due to oxidation and preventing and improving aging phenomenon and further having beautifying effects. CONSTITUTION:The objective external preparation contains one or two or more kinds of substances selected from keratins, keratin-hydrolyzed substances, vitamin B2s, vitamin Ds, isopropylmethylphenol, quercetin, quercitrin, rutin, liquiritin, gallic acid, gallic acid derivative, catechin and catechin derivative in an amount of 0.0001-5.0wt.% as a solid content in total composition and further contains one or two or more kinds of extracts of plants selected from dried flower bud of Rosa rugosa var. plena Regel, dried seed of Prunus japonica Thunb. and dried fruit of Chaenomeles lagenaria Koidz. in an amount of 0.0001-10.0wt.% as a solid content. This preparation is stable, safe and safely usable and capable of preventing and improving aging phenomenon of skin such as loss of skin gloss or tenseness skin and further excellent in beautifying effects and useful for prevention and improvement of burning sensation, stain and ephelis after sunburn, blackening of skin due to sunburn, etc.
PURPOSE:To produce tungsten compd. of an Anderson structure expressed by a specific formula by effecting the reaction of tungsten oxide with potassium hydroxide in the presence of antimony oxide and salt of mineral acid with europium. CONSTITUTION:The new tungsten compd. having an Anderson chemical structure is expressed by K6[W7O24].8H2O. To produce this compd., for example, 4g of WO3 is added to 30ml aq. solution containing 2.5g KOH, heated while stirred to dissolve. Then 0.8g of Sb2O3 and 0.3g of Eu(NO3)3.6H2O both dissolved in 3ml concd. hydrochloric acid is gradually added to the heated solution and controlled to pH=7.4 with using KHCO3. Then the mixture is cooled to room temp. for about two hours, filtered to separate precipitate. The filtered liquid is then left to stand at room temp. to precipitate crystalls.
A half of the participants will be randomly allocated to the probiotics group. They will receive probiotic lozenge before falling asleep for12 weeks. They will receive hygienic and dietetic instructions. examination will be conducted before study and after 12 weeks.
The invention discloses a method for verifying the effectiveness of a pulmonary arterial hypertension targeted drug, which uses TTCI (time to clinical improvement) to verify the effectiveness of PAH (advanced drug delivery system) targeted drugs. Compared with clinical deterioration time, more positive endpoint events can be observed within 24 weeks by adopting TTCI, the research period of the TTCI is short, the required research sample size is small, and the TTCI can be used in short-period research. The TTCI employed in this application is not affected by patient baseline risk stratification, and is hooked up to patient long-term survival, relative to 6MWD. In addition, TTCI can identify that the 6MWD failed to detect therapeutic differences, the overall effect is superior to 6MWD, a more suitable clinical surrogate endpoint for short-cycle validation of PAH targeted drug effectiveness. The TTCI shortens the research period of clinical trials of PAH targeted drugs, can promote the research efficiency of the effectiveness of the targeted drugs, reduces the follow-up time of patients and more rapidly identifies the effective drugs. Meanwhile, the study of the ineffective medicine can be stopped in time, and the injury of the long-term treatment of the ineffective medicine to study population is avoided.
The control group will receive 50 minutes of conventional physiotherapy intervention twice a week for 12 weeks. The protocol of conventional physiotherapy will be customized and will include exercises to improve strength and muscle power, flexibility, mobility, balance, and aerobic conditioning exercises. In particular cases, when necessary analgesia will be used to relive pain.
An experienced special educational needs (SEN) teacher will teach the participants social interaction skills through tradidactic instructions and role-play activities. Four modules will be covered in the 4-week training: (1) how to introduce yourself and basic social skills; (2) how to listen to others; (3) how to share with others; (4) learn to know how people feel and how to empathise. These modules have been applied in many studies (Braswell \& Bloomquist, 1991; Huang et al., 2015). The content of this training will be as similar as possible to the SocVR training. The training lasts 20 minutes which depends on the emotion of the participants. Each training session will be conducted in a classroom independently for each participant.
A fruit-vegetable facial mask device is provided, which includes a stirring grinder and a film-forming device. The stirring grinder is arranged above the film-forming device and comprises a material cup, a stirring shaft, a material cup plug and a material cup base, wherein the stirring shaft is vertically arranged in the center of the material cup and is provided with blades. The material cup plug is arranged on the material cup base and is closely matched with a lower opening of the material cup. The upper opening of the material cup is provided with a cover of feeding opening. The upper end and the lower end of the stirring shaft are rotatably connected with the cover of feeding opening and the material cup base respectively, and the material cup base is internally provided with a blanking channel. The fruit-vegetable facial mask device has the advantages of reasonable design, simple structure, firmness and durability, long service life, and high efficiency and good quality for making a facial mask. The device has strong practicability and popularization values, and can be used by families or beauty shops.
The patient was adequately sedated by intravenous administration of midazolam with or without meperidine. ESP and pancreatic duct stent insertion were undertaken using two methods: conventional and wire-guieded ESP. The conventional ESP method was performed as in the follows. After placing the tip of the duodenoscope on the tumor, the snare was deployed so that it grasped the base of the tumor. Constant tension was applied to the snare loop during excision until the lesion was transected. Excision was performed with a small sized electrosurgical snare. A pancreatic duct stent was or was not inserted immediately after the excision. The wire-guided ESP method was performed as follows. An ERCP catheter was inserted into the pancreatic duct. Then, a 0.035-inch guidewire was inserted through the catheter and deep into the main pancreatic duct. After the ERCP catheter was removed, the loop of an electrosurgical snare with a maximum sheath diameter of 1.8 mm was passed over the guidewire, in monorail fashion, and the snare was closed lightly. The snare was introduced next to the guidewire into the accessory channel of the duodenoscope. After the tip of the duodenoscope was placed on the tumor, the snare was deployed so that it grasped the base of the tumor. Constant tension was applied to the snare loop during excision until the lesion was transected. After the excision was completed, a pancreatic duct stent was immediately passed over the guidewire previously placed in the pancreatic duct and was positioned across the pancreatic-duct oriﬁce. ESP was performed by using the blend mode or endocut mode setting on the electrosurgical generator. A straight or single pigtail type, 3- to 9-cm, 3 to 7F polyethylene pancreatic duct stent was used. Post-papillectomy bleeding was treated with argon plasma coagulation (APC) and/or endoscopic clipping or epinephrine injection. APC was carried out with a power setting of 60 W and a gas flow of 2 L/min. One to seven days after stent placement, a plain abdominal radiograph was obtained to determine its position. If it had not passed spontaneously, it was removed endoscopically from those patients with no evidence of pancreatitis.
BACKGROUND: Transaxillary endoscopic thyroidectomy (TAET) is favored for its favorable cosmetic outcomes and the preservation of anterior cervical function. Despite these benefits, postoperative analgesia has traditionally relied on pharmacological interventions, and regional anesthetic procedures may be an alternative method. This study aimed to evaluate the efficacy of an ultrasound-guided pectoserratus plane block (PSPB) combined with an intermediate cervical plexus block (ICPB) for TAET.
METHODS: Forty patients undergoing TAET were randomized into two groups: the nerve block group (N.=20) received ultrasound guided PSPB with 20 ml of 0.375% ropivacaine and ICPB with 8 mL of 0.3% ropivacaine, while the control group (N.=20) received no block. The primary outcome was the Visual Analog Scale (VAS) scores for postoperative neck and axillary pain at different time points (1, 6, 12, 24 h) during rest and movement post-TAET. The secondary outcomes included intraoperative remifentanil consumption, incidence of postoperative nausea and vomiting (PONV), number of remedial analgesic requirements, and patient satisfaction postoperatively.
RESULTS: Compared to the control group, patients in the nerve block had significantly lower VAS scores of the neck and axilla whether at rest or movement, and 1, 6, 12, and 24 h postoperatively (P<0.0125). The nerve block group showed higher patient satisfaction (P<0.001). No difference was observed in intraoperative remifentanil consumption, need for rescue analgesics, or other adverse effects 48 h postoperatively.
CONCLUSIONS: Ultrasound-guided PSPB with ICPB significantly alleviated postoperative pain and improved patient satisfaction with TAET.
Gray mold caused by Botrytis elliptica is one of the most determinative factors of lily growth and has become a major threat to lily productivity. However, the nature of the lily B. elliptica interaction remains largely unknown. Here, comparative transcriptomic and metabolomic were used to investigate the defense responses of resistant ('Sorbonne') and susceptible ('Tresor') lily cultivars to B. elliptica infection at 24 hpi. In total, 1326 metabolites were identified in 'Sorbonne' and 'Tresor' after infection, including a large number of phenylpropanoids. Specifically, the accumulation of four phenylpropanes, including eriodictyol, hesperetin, ferulic acid, and sinapyl alcohol, was significantly upregulated in the B. elliptica-infected 'Sorbonne' compared with the infected 'Tresor', and these phenylpropanes could significantly inhibit B. elliptica growth. At the transcript level, higher expression levels of F3'M, COMT, and CAD led to a higher content of resistance-related phenylpropanes (eriodictyol, ferulic acid, and sinapyl alcohol) in 'Sorbonne' following B. elliptica infection. It can be assumed that these phenylpropanes cause the resistance difference between 'Sorbonne' and 'Tresor', and could be the potential marker metabolites for gray mold resistance in the lily. Further transcriptional regulatory network analysis suggested that members of the AP2/ERF, WRKY, Trihelix, and MADS-M-type families positively regulated the biosynthesis of resistance-related phenylpropanes. Additionally, the expression patterns of genes involved in phenylpropanoid biosynthesis were confirmed using qRT-PCR. Therefore, we speculate that the degree of gray mold resistance in the lily is closely related to the contents of phenylpropanes and the transcript levels of the genes in the phenylpropanoid biosynthesis pathway. Our results not only improve our understanding of the lily's resistance mechanisms against B. elliptica, but also facilitate the genetic improvement of lily cultivars with gray mold resistance.
The prevalence of obesity is increasing worldwide, resulting in various health issues such as hypertension, dyslipidemia, diabetes mellitus, heart disease, and a lower life expectancy. Importantly, several psychiatric disorders and the use of psychotropic medications have been linked to obesity, and the possible risk factors need further investigation. This study examined the prevalence of obesity and its associated factors using a self-administered questionnaire. Participants were recruited from three outpatient clinics and individuals who met one or more of the ICD-10 F0-F9, G4 diagnoses were included. In total, 1384 participants completed the questionnaire about their lifestyle. Statistical analysis compared the demographic and clinical characteristics of the individuals who were obese (Body Mass Index: BMI ≥25) and those who were non-obese (BMI <25). The results revealed that the factors associated with obesity in psychiatric outpatients were being male, prolonged treatment duration, eating out frequently, and use of both second- and first-generation antipsychotics. The study emphasized the importance of closely monitoring BMI in individuals with multiple obesity-related factors.
Production of a suspension of an undecomposed meltable material having an average particle diameter of 5-500 nm comprises preparing an emulsion from the undecomposed meltable material, a liquid phase in which the material is sparingly soluble, and an effective amount of a surface modifying agent; and releasing the pressure in a zone of reduced pressure so that the emulsion is cooled to below the melting point of the material.  Preferred Features: The average particle diameter is 10-300 nm. The emulsion is produced in the first step while the material is melted with the liquid phase and the surface modifying agent. The emulsion is cooled below the melting point of the material by partial vaporization of the liquid phase. The pressure in the second step is 10-800, preferably 20-300 mbar. The emulsion in the second step is 5-50, preferably 10-20 wt.% of the liquid phase.
PURPOSE:To provide the subject porcelain material containing an antibacterial zeolite, capable of continuously suppressing the proliferation of bacteria attached to the surface under the gingival crest and effective in preventing periodontosis. CONSTITUTION:The objective porcelain material contains 6-8% of an antibacterial zeolite, continuously suppresses the proliferation of bacteria (e.g. Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus cereus or Pseudomonas aeruginosa) and fungi (e.g. Trichophyton or Rhizopus nigricans) attached to the surface of artificial dental crown and is effective in preventing periodontosis. The porcelain material is e.g dentin porcelain for porcelain jacket crown, dentin porcelain for metal-bond and margin porcelain for metal-bond. The porcelain material can be produced e.g. by adding a coloring metal oxide, etc., to a main raw material consisting of 77% of potassium feldspar, 15% of quartz and 8% of antibacterial zeolite, heating the mixture at 1,300-1,500 deg.C to obtain molten glass, throwing the glass into water, crushing the obtained frit and heat-treating the obtained powder at 700-1,100 deg.C to precipitate leucite crystals in the molten glass.
Pharmacist questions regarding presence of LUTS, with provision of healthy aging literature. Follow-up at 6 weeks.
Autotaxin (ATX) contributes to the production of lysophosphatidic acid (LPA), which is associated with fibrosis development in idiopathic pulmonary fibrosis (IPF). The ATX inhibitor ziritaxestat failed to reduce decline in forced vital capacity (FVC) in patients with IPF in ISABELA 1 and 2 (NCT03711162 and NCT03733444), two identically designed phase III studies. In the current analysis, we evaluated pharmacokinetic and pharmacodynamic data from the pooled ISABELA studies to determine whether the lack of efficacy could be attributed to insufficient exposure and/or target engagement. Nonlinear mixed effect modeling was performed to predict ziritaxestat exposure in individual patients and describe its effect on LPA C18:2 levels. We assessed whether there was a correlation between ziritaxestat and ATX concentration and evaluated the relationship between LPA C18:2 reduction and change from baseline in FVC. Ziritaxestat exposure in patients with IPF was numerically lower in those who received ziritaxestat on top of pirfenidone than in those who received ziritaxestat on top of nintedanib or ziritaxestat alone. In most patients, LPA C18:2 reduction was comparable to that reported in healthy volunteers. ATX concentrations increased over time and correlated weakly with ziritaxestat exposure and LPA C18:2 reduction. No correlation between reduction in LPA C18:2 and change from baseline in FVC was apparent. Based on these evaluations, exposure and target engagement are not thought to have contributed to the lack of efficacy observed. We hypothesize that the lack of efficacy of ziritaxestat in the ISABELA program, despite adequate LPA reduction, could be due to the involvement of an alternative pro-fibrotic pathway.
Over-consumption of fructose in adults and children has been linked to increased risk of non-alcoholic fatty liver disease (NAFLD). Recent studies have highlighted the effect of fructose on liver inflammation, fibrosis, and immune cell activation. However, little work summarizes the direct impact of fructose on macrophage infiltration, phenotype, and function within the liver. We demonstrate that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes. In addition, fructose increased fibrotic gene expression of collagen 1 alpha 1 (Col1a1) and tissue metallopeptidase inhibitor 1 (Timp1) as well as inflammatory gene expression of tumor necrosis factor alpha (Tnfa) and expression of transmembrane glycoprotein NMB (Gpnmb) in liver tissue compared to glucose and control diets. Single cell RNA sequencing (scRNAseq) revealed fructose elevated expression of matrix metallopeptidase 12 (Mmp12), interleukin 1 receptor antagonist (Il1rn), and radical S-adenosyl methionine domain (Rsad2) in liver and hepatic macrophages. In vitro studies using IMKC and J774.1 cells demonstrated decreased viability when exposed to fructose. Additionally, fructose increased Gpnmb, Tnfa, Mmp12, Il1rn, and Rsad2 in unpolarized IMKC. By mass spectrometry, C13 fructose tracing detected fructose metabolites in glycolysis and the pentose phosphate pathway (PPP). Inhibition of the PPP further increased fructose induced Il6, Gpnmb, Mmp12, Il1rn, and Rsad2 in nonpolarized IMKC. Taken together, fructose decreases cell viability while upregulating resolution and anti-inflammatory associated genes in Kupffer cells.
Patients receive oral dasatinib twice daily on days 1-21. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.
Patients receive dexamethasone IV over 15 minutes, etoposide IV over 3 hours, and cytarabine IV over 3 hours on days 1-2. Patients receive 2 drops of dexamethasone ophthalmic solution every 6 hours on days 1, 2 and 3. Patients also receive cisplatin PO or IV over 12 hours as pre-hydration followed by continuous IV over 6 hours on day 1 and G-CSF SC beginning on day 3 and continuing until blood counts recover. Treatment repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity. Patients then receive 2 additional courses of ABVE-PC chemotherapy. Patients with sustained complete or partial response undergo IFRT approximately 3 weeks after the last course of chemotherapy.
The invention discloses an antibacterial composition, an implant material coated with the antibacterial composition, and a preparation method of the implant material. The antibacterial composition comprises a thermoplastic polyurethane elastomer and an antibacterial agent. The implant material is prepared by the following steps: coating the antibacterial composition on the implant material through high-pressure electrospinning to form an antibacterial coating, so as to obtain the implant material with an antibacterial function. The antibacterial agent can be effectively fixed by the thermoplastic polyurethane elastomer in the antibacterial composition. Swelling leakage is avoided even if in an in-vivo complex environment by utilizing a hard shell structure formed by high-pressure electrospinning, the antibacterial agent can be effectively fixed, and the antibacterial agent is firmly combined with the material, cannot be released, is low in biotoxicity and has high biocompatibility. The preparation method is simple in process, easy to operate, low in cost and convenient for implementation of large-scale production.
The intervention consists of 30 active rTMS sessions. Each session is comprised of 300 trains of paired pulses with the following parameters: 100µs paired pulses separated by 100ms inter-pulse-intervals and a five second inter-train-interval. Pulse intensity will be set at 110% of each participant's motor threshold. Active rTMS sessions will be provided two times per day with a 70mm figure-of-eight coil over the left dorsolateral prefrontal cortex. Two Magstim-2002 units and a Bistim2 module will be used to administer active rTMS. Participants assigned to the active rTMS group will receive a total of 1.8 seconds of stimulation. Active rTMS will be administered 2 times daily with the following weekly schedule: 2 days of rTMS, 1 day of rest, 2 days of rTMS, 2 days of rest.
The invention relates to proteins comprising serine protease inhibiting peptides, such as Kunitz domain peptides (including, but not limited to, fragments and variants thereof) fused to albumin, or fragments or variants thereof. These fusion proteins are herein collectively referred to as "albumin fusion proteins of the invention."These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses, therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting neutrophil elastase, kallikrein, and plasmin. The invention further relates to compositions and methods for treating cystic fibrosis and cancer.
Pain is a crucial protective mechanism for the body. It alerts us to potential tissue damage or injury and promotes the avoidance of harmful stimuli. Injury-induced inflammation and tissue damage lead to pain sensitization, which amplifies responses to subsequent noxious stimuli even after an initial primary injury has recovered. This phenomenon, commonly referred to as hyperalgesic priming, was investigated in male and female mice to determine whether it is specific to the site of previous injury. We used 10μl of 50 % Freund's complete adjuvant (CFA) administered to the left hind paw as a model of peripheral injury. Both male and female mice exhibited robust site-specific mechanical hypersensitivity after CFA, which resolved within one-week post-injection. After injury resolution, only male CFA-primed mice showed enhanced and prolonged mechanical sensitivity in response to a chemical challenge or a single 0.5 mA electric footshock. Among CFA-primed male mice, shock-induced mechanical hypersensitivity was expressed in both the left (previously injured) and the right (uninjured) hind paws, suggesting a pivotal role for altered centralized processes in the expression of pain sensitization. These findings indicate that pain history regulates sensory responses to subsequent mechanical and chemical pain stimuli in a sex-specific manner-foot-shock-induced hyperalgesic priming expression among male mice generalized beyond the initial injury site.