anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In an open-label study, 57 clinically stable, elderly patients (≥ 65 years old) with schizophrenia or schizoaffective disorder received Risperidone for Extended-Release Injectable Suspension every 2 weeks for up to 12 months. In general, no differences in the tolerability of Risperidone for Extended-Release Injectable Suspension were observed between otherwise healthy elderly and nonelderly patients. Therefore, dosing recommendations for otherwise healthy elderly patients are the same as for nonelderly patients. Because elderly patients exhibit a greater tendency to orthostatic hypotension than nonelderly patients, elderly patients should be instructed in nonpharmacologic interventions that help to reduce the occurrence of orthostatic hypotension (e.g., sitting on the edge of the bed for several minutes before attempting to stand in the morning and slowly rising from a seated position). In addition, monitoring of orthostatic vital signs should be considered in elderly patients for whom orthostatic hypotension is of concern [see Warnings and Precautions (5.7)].

Concomitant use with Furosemide in Elderly Patients with Dementia-Related Psychosis 

In two of four placebo-controlled trials in elderly patients with dementia-related psychosis, a higher incidence of mortality was observed in patients treated with furosemide plus oral risperidone when compared to patients treated with oral risperidone alone or with oral placebo plus furosemide. No pathological mechanism has been identified to explain this finding, and no consistent pattern for cause of death was observed. An increase of mortality in elderly patients with dementia-related psychosis was seen with the use of oral risperidone regardless of concomitant use with furosemide. Risperidone for Extended-Release Injectable Suspension is not approved for the treatment of patients with dementia-related psychosis [see Boxed Warning and Warnings and Precautions (5.1)].
TIME at Home is a virtual, group, task-oriented exercise program targeting balance and mobility. A community organization delivers two 1.5-hour sessions per week, for 8 weeks using Zoom.
Azoles such as nafimidone, denzimol and loreclezole are known for their clinical efficacy against epilepsy, and loreclezole acts by potentiating γ-aminobutyric acid (GABA)-ergic currents. In the current study, we report a series of azole derivatives in alcohol ester and oxime ester structure showing promising anticonvulsant effects in 6 Hz and maximal electro shock (MES) models with minimal toxicity. The most promising of the series, 5f, was active in both 6 Hz and MES tests with a median effective dose (ED50) of 118.92 mg/kg in 6 Hz test and a median toxic dose (TD50) twice as high in mice. The compounds were predicted druglike and blood-brain barrier (BBB) penetrant in silico. Contrary to what was expected, the compounds showed no in vitro affinity to GABAA receptors (GABAARs) in radioligand binding assays; however, they were found structurally similar to peroxisome proliferator-activated receptors alpha (PPAR-α) agonists and predicted to show high affinity and agonist-like binding to PPAR-α in molecular docking studies. As a result, 5f emerged as a safe azole anticonvulsant with a wide therapeutic window and possible action through PPAR-α activation.
The invention discloses a preparation method of a tadalafil solid dispersion. The preparation method comprises the steps of dissolving tadalafil and a carrier material in absolute ethyl alcohol; and carrying out rotary evaporation at a reduced pressure and at a temperature of 50-90 DEG C, and thus the tadalafil solid dispersion is obtained. A mass ratio of tadalafil to the carrier material is 1:0.5-1:13; and the carrier material is one or more selected from polyvinylpyrrolidone K30 and poloxamer. The invention also provides a tadalafil solid dispersion tablet. The tadalafil solid dispersion tablet is composed of the tadalafil solid dispersion, filler, a disintegrant and a lubricant. The use amount of the filler is 40-70% of a total weight of the tablet; the use amount of the disintegrant is 0.5%-10% of a total weight of the tablet; and a use amount of the lubricant is 0.1%-5% of a total weight of the tablet. The tadalafil solid dispersion and the tablet thereof provided by the invention increase in-vitro dissolution rate of tadalafil, and overcome the disadvantages of poor oral absorption and low bioavailability.
An antigenic composition is derived from surface extracted protein of cell wall surfaces and the culture supernatant extract of Staphylococci. The strain is highly virulent and β hemolytic on blood agar plate. They are mixed and purified by ion exchange and gel filtration column chromatography. This preparation method can be used in all Gram-positive bacilli. The antigens, having molecular weight of about 10,000-70,000 are certain kinds of glycoprotein comprising proteins (ca. 10-20%) and carbohydrates (ca. 75-90%). They are extracted from the cells with the use of a hypertonic buffer solution of pH 6.5-8.5 at a temperature below the denaturing point of the antigenic protein, and are salted out with ammonium sulfate (ca. 65-85%). The culture supernatant is extracted in the same way by salting out with ammonium sulfate (ca. 65-85%). The antigen fraction from both cell wall and culture supernatant is obtained in such an operation. The antigen can be used as a preparation antigen to Staphylococcus antigen. Namely, the antibody obtained from mammal and avian immunized by this antigen can be used to treat the above-described infections. The composition containing the antibody provides a preventive effect.
ENTREN-F has the same children's intervention than ENTREN. It has extra 6 2-hr sessions to work on family environment and communication, plus three 2-hr sessions attended by both families and children together. One 2-hr session at 6, 12 and 18-month follow-up was provided to refresh skills, their physical activity, and nutritional behaviours.
Vascular inflammation plays an important role in the pathogenesis of atherosclerosis and may contribute to stiffening of arteries that increases the risk of myocardial infarction and stroke. Accordingly, therapies that reduce vascular inflammation may reduce cardiovascular risk. The effect of estrogen therapy on serum markers of inflammation in postmenopausal women is divergent: Estrogen increases the levels of C-reactive protein, interleukin-6, and matrix metalloproteinase-9 ( MMP-9), but decreases levels of the soluble cell adhesion molecules ICAM-1, VCAM-1 and E-selectin. MMP-9 is secreted by macrophages and cytokine-activated smooth muscle cells, with increased expression in the vicinity of atherosclerotic plaques. Although activation of MMP-9 by estrogen could be deleterious in women with coronary artery disease by digesting the fibrous caps of vulnerable plaques and provoking thrombosis (consistent with the Heart and Estrogen/progestin Replacement Study), activation of MMP-9 in healthy postmenopausal women may remove excess matrix proteins that contribute to arterial stiffness (reduced compliance), thus reducing cardiovascular risk (consistent with the Nurses' Health Study). Reduction of levels of cell adhesion molecules might protect against new plaque development in both groups of women. The purposes of this protocol are to determine the net effects of estrogen therapy on 1) vascular inflammation in postmenopausal women, using MRI/MRA imaging of the carotid arteries, and 2) arterial compliance, derived from carotid ultrasonography and blood pressure measurements.
Chronic urticaria is a distressful disease, which negatively affects the quality of life. Pathogenesis isn't exactly clear, treatment is relatively palliative and results are usually suboptimal. 30-40% of the patients have autoimmune origin. Patients are forced to use immunosuppressive treatments which have systemic effects. Some of the treatments have effects as severe as the disease itself.

Mesenchymal stem cells (MSCs) are the most common used cells in clinical trials. These cells can provide efficient immunosuppression in severe conditions like immunosuppressive resistant Graft versus Host Disease. With this study at the first time and quite a different approach from conventional treatment, it will be tried an experimental treatment that used in the MSCs for the chronic autoimmune urticaria patients without of definitive treatment.
PURPOSE:To obtain a carrier having a high shelf life by using a compd. selected from the compd. group expressed by the specific formula, treating a carrier consisting of polyacrylamide deposited thereon with an antigen or antibody and treating such carrier with a guanidine salt or urea. CONSTITUTION:The formula denotes the deriv. of carbodiimide and the carrier which consists of the polyacrylamide and is made into the form having a large surface area relative to the weight in order to carry a large quantity of the antigen or antibody is used as the carrier to be used therewith. The carrier is used as the carrier to be used therewith. The carrier is treated with the guanidine salt or urea. The salt of an inorg. or org. acid is used for the guanidine salt; more particularly guanidine hydro chloride exhibits a high effect like urea as a stabilizer for the carrier. The treatment by the deriv. of the carbodiimide or the guanidine salt or urea is executed generally by immersing the carrier consisting of the polyacrylamide into an aq. soln. or an aq. suspension state. The antigen or antibody can be deposited in the stable state on the carrier if the carrier is constituted in the above-mentioned manner. The produc tion of a large quantity at one time is therefore made possible and the stable supply of the carrier for measurement and the improvement of the measurement accuracy are made possible.
High-risk human papillomavirus (HR-HPV; HPV-16) and cigarette smoking are associated with cervical cancer (CC); however, the underlying mechanism(s) remain unclear. Additionally, the carcinogenic components of tobacco have been found in the cervical mucus of women smokers. Here, we determined the effects of cigarette smoke condensate (CSC; 3R4F) on human ectocervical cells (HPV-16 Ect/E6E7) exposed to CSC at various concentrations (10-6-100 μg/mL). We found CSC (10-3 or 10 μg/mL)-induced proliferation, enhanced migration, and histologic and electron microscopic changes consistent with EMT in ectocervical cells with a significant reduction in E-cadherin and an increase in the vimentin expression compared to controls at 72 h. There was increased phosphorylation of receptor tyrosine kinases (RTKs), including Eph receptors, FGFR, PDGFRA/B, and DDR2, with downstream Ras/MAPK/ERK1/2 activation and upregulation of common EMT-related genes, TGFB SNAI2, PDGFRB, and SMAD2. Our study demonstrated that CSC induces EMT in ectocervical cells with the upregulation of EMT-related genes, expression of protein biomarkers, and activation of RTKs that regulate TGFB expression, and other EMT-related genes. Understanding the molecular pathways and environmental factors that initiate EMT in ectocervical cells will help delineate molecular targets for intervention and define the role of EMT in the initiation and progression of cervical intraepithelial neoplasia and CC.
The usual dose of lisinopril tablets (10 mg) is recommended for patients with creatinine clearance >30 mL/min (serum creatinine of up to approximately 3 mg/dL). For patients with creatinine clearance ≥10 mL/min ≤30 mL/min (serum creatinine ≥3 mg/dL), the first dose is 5 mg once daily. For patients with creatinine clearance <10 mL/min (usually on hemodialysis) the recommended initial dose is 2.5 mg. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily.

* See WARNINGS, Anaphylactoid Reactions During Membrane Exposure.

†Dosage or dosing interval should be adjusted depending on the blood pressure response.
Noradrenaline: Noradrenaline 2amp (4000mcg in 50ml) at 6ml/hr = 7.5mcg/min and dose maximum 60mcg/min 24ml/hr double strength. The dose to be increased every 15min from start dose by 1ml and to decrease by 0.5ml every 15min keeping MAP (Mean Arterial Pressure)\>65.
In the sham stimulation group, the programming will also start within 1 week after the surgery, but at each follow-up the DBS system will be turned off after the parameter is adjusted to the threshold that causes side effects without continuous stimulation. After the 3-month double-blind period the patients can choose to set on the DBS system again and receive regular continuous stimulation treatment.
The procedure of in vitro fertilisation (IVF) is used to treat the infertility problems. The procedure includes ovary aspiration, to isolate oocytes. During the aspiration the patient is sedated with short-term intravenous aesthetic. Premedication is often used in anaesthesiology, and includes drugs application 30 minutes prior to procedure to sedate and treat the anxieties of the patient. One of the most often used drugs in premedication is midazolam. As the procedure is quite stressful for the patients, our aim is to investigate the influence of midazolam premedication on the stress release during the oocyte aspiration procedure, as well as its influence on the whole IVF procedure. Therefore, patients will be divided into two groups, control and midazolam. Blood samples will be taken before and during the procedure. Stress, antioxidant parameters (with glutathione and catalase) and oxidative status will be monitored in serum and follicular fluid.

The results will be correlated with subjective stress levels in the two groups in an effort to establish ties with IVF results.
The present invention relates to a novel compound in a formula (I). The present invention also provides a novel strain-Altemaria alternate var. Monosporus variant ST-026-R CGMCC No. 0899 capable of producing the novel compound in the formula (I). The strain of the present invention is cultivated in a culture medium in order to generate and gather the novel compound of the formula (I) of the present invention in a strain cell and the culture medium. The recovering procedure and the purifying procedure are carried out in the cell and the culture medium. The novel compound of the formula (I) of the present invention is obtained. The compound has high anticancer biological activity, antimycotic biological activity, antivirus biological activity, etc.
Group A will receive 30 mg of CoQ10 daily, after teh two-month study period, teh clinical periodontal parameters were reassessed. Additionally, to compare teh total antioxidant capacity in saliva before and after teh intake of these supplements, as well as in patients who did not receive any medication, 2 ml of non-stimulated saliva was collected from each participant at teh beginning and end of teh study for analysis using UV-spectrophotometric methods, furthermore, teh following criteria determined teh selection of eligible participants for dis study.
FIELD: medicine. SUBSTANCE: method involves administering two therapeutic agents one of which is N-methyl-D-aspartate antagonist selective relative to forebrain and an agent exciting biofeedback between ventral lateral thalamus nucleus and cerebral cortex. The amount of each of the mentioned agents is enough for achieving synergy effect. The agents are optionally administered separately or united in a pharmaceutical composition. EFFECT: enhanced effectiveness of treatment. 42 cl
Individuals in the yoga group of the study had 10 minutes of meditation, 10 minutes of warm-up, and 40 minutes of vinyasa yoga practice, 2 days a week face-to-face and 1 day online, for a total of 12 weeks.Yoga practice was standardized throughout the study to avoid the risk of intervention variability. The basic structure of each yoga session is meditation, breathing exercises (pranayama), and after a warm-up, yoga practice includes asanas (postures) for strength, balance and mobility, and finally ends with relaxation.
The study will be a single blind randomized controlled trial, which utilize quantitative method of data collection. College students who will receive a mobile text message about the behavioral risks of cancer and prevention mechanism will be considered as intervention groups while controls will be those who receive a text message related with general health once a week. A total of 160 (80 interventions and 80 controls) students will be included in the study using simple random sampling technique. After the baseline assessment, participants will be randomized to either usual care (control) or the text message intervention group in a uniform 1:1 (control: intervention) allocation ratio, using computer-based randomization service.

Self-administered questionnaire will be used to assess baseline and end line data of behavioral risk factors and other variables. Participants in the control group will receive an initial text message welcoming them to the study, but they will not receive the text message support program. The intervention group will receive a text message support program, where they will receive seven messages per week at random times and days for two months. The text message will be prepared and delivered based on health belief model (HBM), the items of this subscale will be measured on a Likert scale ranging from 1= "Strongly disagree" to 5 = "Strongly agree". Tobacco use, harmful use of alcohol, unhealthy diet and physical inactivity with a series of items will be used to measure the behavioral outcomes the items in this subscale will be measured on a Likert scale.

Validity of the items will be measured by an expert panel of specialists in health education and nutrition. They will judge about the necessity and relevance of the scale items. To control the data quality all data collectors will be trained for two days. Supervisors will monitor data collection process and the principal investigator will visit frequently. The questionnaire will be first prepared in English language and translated to Amharic and again re-translated in to English by another person to check for consistency. About 10% of the questionnaire will be pretested and internal consistency will be checked. Completeness of the collected data will be checked during data collection.

The data will be checked for completeness and consistency, then categorized, coded and entered using Epidata version 3.1 to minimize error. Then, the clean data will be exported to Stata version 14 for analysis. Normality of the data will be checked through Kolmogorov-Smirnov test. Student's paired samples t-test will be used to test within-group changes in terms of health belief model (HBM) variables and behavioral outcomes. The analysis of Covariance will be used to make over-group comparisons. Data will be reported as mean ± standard deviation. The significance level for all of the results will be presented at the P\<0.05 level.
<P>PROBLEM TO BE SOLVED: To extract observations and a location from a diagnostic reading report written by a free format.  <P>SOLUTION: Sentence structure of respective sentences included in the diagnostic reading report is analyzed by a syntax analysis means 2b. Sentences including designated wordings showing objective facts in a predicate are selected by an observation determining means 2c as observation sentences. The wordings showing an object of the predicate are extracted, and they are determined by the observation determining means 2c as observation sentences. The wordings showing a location of the object of the observation sentences are extracted by a part determining means 2d, and they are determined as an observation target part. Accordingly, results showed by the observation determined by the observation determining means 2c to the observation object part determined with the part determining means 2d are outputted.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The universe of the research; patients who are planned to undergo total knee arthroplasty between January 1, 2021 and June 1, 2021 in the orthopedic surgery clinic where the study will be conducted will comprise the patients who meet the inclusion criteria and agree to participate in the study. The research was planned as a randomized controlled experimental study. Block randomization method will be used to determine the experimental and control groups. In order for the groups to be distributed homogeneously, the order produced by a computer program (www.randomizer.org) will be used. Randomization will be done by a biostatistician outside the researcher. Patients who meet the inclusion criteria and agree to participate in the study will be assigned to the experimental and control groups according to the randomization list. Research data will be collected in a hospital's orthopedics and traumatology service surgery ward between 1 January 2021 - 1 June 2021.

The dependent variables of the study are postoperative statue anxiety score, patient self-care ability score, pain severity (Visual Analog Scale-VAS), pain control and status ( pain-causing conditions, analgesic such as use case), patient satisfaction score, re-hospitalization average. In the research, "Individual Characteristics Form" and "Patient Follow-up Form" prepared by the researcher in line with the literature will be used as data collection tools.
The present invention relates to a cosmetic composition including a Schisandra extract and a method for producing the same. Lip balm has a constant hardness in the room temperature range and has excellent antioxidant, anti-inflammatory, and antibacterial actions. By using natural preservatives, synthetic preservatives remove skin troubles, and an antiseptic effect is exhibited. It is possible to resolve conventional problems in which a hardness change is easy according to a temperature change and a synthetic preservative causing skin troubles is used. The composition of the present invention comprises: lip balm in which oats, Schisandra, paprika, and agar are mixed in a liquid volume ratio of 2:2:3:3 so that hardness is constant in the room temperature range and antioxidant, anti-inflammatory, and antibacterial actions are excellent; and a natural preservative which is composed of vitamin E as a main ingredient to remove the occurrence of skin troubles due to synthetic preservatives and exhibit an antiseptic effect. Accordingly, due to lip balm, hardness is constant in the room temperature range, and excellent antioxidant, anti-inflammatory, and antibacterial actions are excellent. By using natural preservatives, it is possible to remove the occurrence of skin troubles due to synthetic preservatives, and an antiseptic effect can be exhibited. It is possible to resolve conventional problems in which a hardness change is easy according to a temperature change and a synthetic preservative causing skin troubles is used.
PROBLEM TO BE SOLVED: To determine the lysine bonding position of free human plasminogen directly removing a coexisting substance to be measured using an antibody therefor as a pretreatment at the time of separating and measuring the decomposed products of plasminogen. SOLUTION: Plasminogen fragments produced through decomposition are immunized respectively to prepare an antibody. Subsequently, an immunoaffinity column is prepared using the antibody as ligand. A sample is passed through the immunoaffinity column where only mini-plasminogen and complete molecular plasminogen are captured and the unadsorbed passed fraction (lysine bonding position-I, II) is measured by immunoassay. In this regard, enzyme immunoassay, radioimmunoassay or latex immunonephelometry is selected arbitrarily. According to the method, lysine bonding position in the plasma of healthy person and cancer patient can be measured.