anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subject assigned to CAMS for Phase 1. Subject is a Phase 1 CAMS Responder, thus placed into ongoing Maintenance/Monitoring.
The present invention relates to a traditional Chinese drug for treating diabetes. With the present invention, the therapeutic medication problem of the diabetes can be effectively solved. The technical scheme for solving the problem is that: the traditional Chinese drug is prepared from 13-17 g of ginseng, 13-17 g of creeping liriope, 13-17 g of mongolian snakegourd fruit, 13-17 g of longstamen onion bulb, 13-17 g of wenchow turmeric root tuber, 13-17 g of rehmannia dride rhizome, 30-40 g of mongolian milkvetch root, 13-17 g of coptis chinensis, 13-17 g of angelica, 9-11 g of leech, 9-11 g of sanchi, 13-17 g of common yam rhizome, 13-17 g of medicinal morinda root, and 16-20 g of safflower. The preparation method comprises: respectively crushing the ginseng, the mongolian snakegourd fruit, the angelica, the wenchow turmeric root tuber, the rehmannia dride rhizome, the coptis chinensis, the leech, the sanchi and the common yam rhizome, and screening through a sieve with 300 meshes to provide a spare use; adding water to the creeping liriope, the longstamen onion bulb, the mongolian milkvetch root, the medicinal morinda root, and the safflower, immersing for 30-60 minutes, decocting two times, filtering, mixing the decocting solutions from the two decocting treatments, and condensing to obtain the extract with the relative density of 1.20-1.30 to provide a spare use, wherein each decocting time is 1.5 hours; mixing the fine powders and the extract, preparing into the drug lump, adopting a conventional method to prepare pills and coat sugarcoating to obtain the traditional Chinese drug of the present invention. The traditional Chinese drug of the present invention has characteristics of abundant raw materials, easy production, low cost, convenient taking, and good effect. With the traditional Chinese drug of the present invention, the abnormal rheological characteristic of the blood can be corrected, the blood glucose can be reduced, and the traditional Chinese drug can be effectively used for treatment of the diabetes.
Intreduction: Melanoma is an extremely aggressive form of skin neoplasia, an important stage in the diagnostic and treatment is identifying the dissemination at the lymphatic level. For a more accurate staging, the sentinel lymph node biopsy technique is performed, which in most of the time addresses one, respectively 2 locations, but cases with sentinel nodes in 3 lymphatic basins have rarely been described. Case report: We present a case of melanoma located in the right lumbar region, which from the point of view of histopathological features has a Breslow index of 4.2 mm, classified in the pT4b stage. After the CT evaluation was performed, it was decided that there is indication for performing the sentinel lymph node technique and excision with a margin of safety. Scintigraphy revealed that sentinel lymph nodes were identified in 3 different regions, respectively the right axilla and bilateral inguinal. Conclusions: Melanoma located on the trunk can present different lymphatic routes for the sentinel lymph nodes, unlike that on the limbs where certain patterns are present. Identifying these lymph nodes in cases like this involves a challenge both from a diagnostic and surgical point of view.
In Group 2, a modification of the standard ureteral stent will be inserted. The stent will be cut through obliquely according to the position of the ureteral calculus. The extend to be removed can be easily measured by the retrograde probing catheter and is replaced by a monofilament, non-absorbable suture as described previously by Vogt et al. (W J Urol, 2015). This suture can be easily attached by puncturing the bevelled stent end.
In this study, 51 patients were allocated to one of the research groups. In Group I, it was instituted counseling therapy. For Group II was conducted treatment as usual with occlusal splint. Patients were followed for returns at 7, 15, 30 and 60 days after baseline. At baseline, all patients were examined and assessed Research Diagnostic Criteria/Temporomandibular Disorder (RDC/TMD form). In addition, the patients were referred for specific treatment according to the group to which belonged. In each session, patients were also surveyed about pain intensity using a Numeric Scale. To analyze the impact of pain on quality of life, Oral Health Impact Profile (OHIP-14) questionnaire was used.
The present invention refers to a nutraceutical encapsulated by micro fluidization with an anti-inflammatory and prebiotic effect, which includes: fatty oil contained in minimally processed fish eyes, which has a high concentration of: i. eicosapantenoic acid (EPA). ii. Decosahexaenoic acid (DHA). The eicosapantenoic acid (EPA) and the decosahexaenoic acid (DHA) are encapsulated by micro fluidization by colloids and a material with probiotic effects that do not inhibit the function of said acids (DHA/EPA) and allow the prebiotic bacteria to grow for improving the digestion. The nutraceutical encapsulated by micro fluidization with anti-inflammatory and prebiotic effect may be applied in food, supplements and complements. The nutraceutical encapsulated by micro fluidization with anti-inflammatory and prebiotic effect may inhibit the cyclooxygenase 2 enzyme (COX-2), involved in the inflammatory process, and reduces the plantar edema induced by carrageenan in mice.
The coronavirus SARS-Cov-2 which started in Wuhan, China, in December 2019 induced a threat to global health. Patients with mental disorders were thought to be at increased risk of becoming infected for several reasons but very much to the inventors' surprise, these psychiatric units remained nearly empty during the lock-down period as if psychiatric patients were protected from SARS-Cov-2 infection. Thus the inventors mined the literature to identify approved drugs with in vitro antiviral activities with a special emphasis on psychotropic drugs and compared these molecules using chemoinformatics strategies to the drugs most commonly used in their psychiatric department. A large number of compounds were found to be cationic amphiphilic drugs (CADs) and as such tend to also be phospholipidosis inducers in vitro (PLD). Several molecules most commonly used in their department were also found to have in vitro antiviral activity and/or can be clustered with compounds with known in vitro antiviral activity. Thus, drugs most commonly used for mental disorders with known in vitro antiviral activities are often CADs. In silico and in vitro analyses of these compounds together with the observations made in the department strongly suggest that commonly used psychotropic drugs and some related anti-histamine agents used as anxiolytics should protect psychiatric patients from SARS-Cov-2 infection.
An electronic fitness test which can also be used as a fitness training device. The test contains preset tests for several disciplines and at several levels. Preferably, the test can also be programmed with further user-defined tests. The test preferably consists of exercise sets and repetitions of these sets. As the repetitions increase, the test becomes more difficult and this enables a student to test and train his fitness against a defined level. Preferably, the test comprises visual displays 1,2,3 to report progress of the exercise program and running time. Preferably the test also includes visual and audio cues for exercise checkpoints 4,5,6.
This is a randomized, double-blind, parallel-group, dose-escalation investigation. Participants ("children" defined as ages 3 - \< 12 years and "adolescents" defined as ages 12 - 17 years) will be randomized 2:1 to either methadone or short-acting opioid. Surgical and anesthesia care, except for intraoperative opioid management, are not altered for study purposes. The trial will include 2 periods in 3 parallel age groups. In the first period, each age cohort will recruit 66 patients (44 methadone, 22 control). Children will be randomized to methadone 0.15 mg/kg age-ideal body weight and adolescents to 0.2 mg/kg age-ideal body weight. When an age cohort reaches 66 patients, this is the end of the first period. At that time, an unblinded interim analysis will be conducted in that cohort to determine if dose escalation to 0.2 mg/kg dose in children and the 0.25 mg/kg dose in adolescents are met. Methadone dose escalation will be based on clinically meaningful differences in need for rescue opioid in the PACU and the absence of well-defined opioid adverse events. Outcomes data will be collected in hospital and after discharge. With daily surveys for 7 days, and 3 phone calls on day 30, 3 months and 6 months after surgery.
Supraventricular Tachycardia

In two multicenter, randomized, double-blind, controlled comparisons of esmolol hydrochloride injection with placebo and propranolol, maintenance doses of 50 to 300 mcg/kg/min of esmolol hydrochloride were found to be more effective than placebo and about as effective as propranolol, 3-6 mg given by bolus injections, in the treatment of supraventricular tachycardia, principally atrial fibrillation and atrial flutter. The majority of these patients developed their arrhythmias postoperatively. About 60-70% of the patients treated with esmolol hydrochloride developed either a 20% reduction in heart rate, a decrease in heart rate to less than 100 bpm, or, rarely, conversion to normal sinus rhythm and about 95% of these patients did so at a dosage of 200 mcg/kg/min or less. The average effective dosage of esmolol hydrochloride was approximately 100 mcg/kg/min in the two studies. Other multicenter baseline-controlled studies gave similar results. In the comparison with propranolol, about 50% of patients in both the esmolol hydrochloride and propranolol groups were on concomitant digoxin. Response rates were slightly higher with both beta blockers in the digoxin-treated patients.

In all studies significant decreases of blood pressure occurred in 20-50% of patients, identified either as adverse reaction reports by investigators, or by observation of systolic pressure less than 90 mmHg or diastolic pressure less than 50 mmHg. The hypotension was symptomatic (mainly hyperhidrosis or dizziness) in about 12% of patients, and therapy was discontinued in about 11% of patients, about half of whom were symptomatic. Hypotension was more common with esmolol hydrochloride (53%) than with propranolol (17%). The hypotension was rapidly reversible with decreased infusion rate or after discontinuation of therapy with esmolol hydrochloride. For both esmolol hydrochloride and propranolol, hypotension was reported less frequently in patients receiving concomitant digoxin.
The patient's hemodynamic data will be measured in the evening service before surgery. The patient will be brought to the operating room by the anesthesiologist on the day of surgery and hemodynamic data (blood pressure, pulse rate, respiratory rate, SpO2) will be measured in the preop unit. The hemodynamic data and the ST-STAI scale will measure the anxiety level in the operating room.
The long-term goal of the proposed project is to improve the treatment of alcohol abuse and dependence in patients with schizophrenia and schizoaffective disorder. Alcohol use disorders are common among patients with severe mental illness. It is estimated that there may be as many as 750,000 individuals in the United States with comorbid schizophrenia and alcohol disorders. Alcohol disorder comorbidity requires treatment because it is associated with adverse consequences such as increased rates of hospitalization. Yet, to date, there are no reports of controlled trials testing the efficacy of pharmacological treatments for alcohol abuse or dependence in this population. Naltrexone pharmacotherapy is an effective treatment for alcohol dependence, but it has not been systematically applied to the care of patients with schizophrenia. The specific aims of this study are: To test the efficacy of naltrexone in reducing alcohol use among individuals with schizophrenia and schizoaffective disorder who also have alcohol abuse or dependence. We will test hypothesis 1: Naltrexone will be more effective than placebo in reducing alcohol use. Our primary outcome measure will be the number of drinking days over the course of the treatment trial. To test naltrexone's efficacy in reducing psychiatric symptom severity and medical utilization by reducing alcohol use. We will test hypothesis 2: Patients responding to naltrexone by reducing alcohol use will also show reductions in severity of psychiatric symptoms and utilization of inpatient and emergency psychiatric services. To determine the relationship between a) changes in alcohol use, and b) psychiatric symptom severity and inpatient and emergency service utilization. We will test hypothesis 3: Severity of psychiatric symptoms and amount of service utilization will correlate positively with alcohol use. The proposed research will study a cohort of 150 subjects in a double-blind, randomized, placebo-controlled trial of naltrexone using three times per week directly observed administration of medication. The study will be 6 months in duration, consisting of a 12-week course of naltrexone or placebo plus 3 monthly follow-up interviews after discontinuation of medication. Voucher incentives contingent on attendance will be provided to all subjects to ensure attendance for medication administration. Weekly motivational enhancement counseling sessions will also be provided to all subjects. Study outcomes will consist of self-report and biological measures of alcohol use as well as measures of psychiatric symptom severity and medical service utilization.
[Problem] To provide an information processing device that is capable of reducing the burden on a user and contributing to improvement in the mental state of the user. [Solution] According to one aspect of the present invention, an information processing device is provided. This information processing device comprises a receiving unit, an extracting unit, and an output unit. The receiving unit receives first mood information pertaining to the mood of a first user. On the basis of the first mood information and reference information, the extracting unit extracts experience diary information which pertains to an experience diary kept by a second user who is different from the first user. The reference information is information indicating the relationship between second mood information about the mood of the second user and the experience diary information. The output unit outputs the experience diary information.
The recurrent laryngeal nerve (RLN), vagus nerve, external branch of the superior laryngeal nerve (EBSLN) and pharyngeal plexus were stimulated intraoperatively by the NIM 3.0 Nerve Monitoring System (Medtronic Xomed, Jacksonville, FL, USA). Responses were evaluated by visual observation of the cricopharyngeal muscle and electromyographies via needle electrodes inserted into the cricopharyngeal muscle.
PURPOSE:To efficiently obtain a dried product at a small quantity of energy by subjecting the aq. soln. of a raw material to be irradiated with far infrared rays under reduced pressure to concentrate it and thereafter icing and freezing it to form a particulate material to be dried and then projecting far infrared rays thereon under vacuum to freeze-dry it. CONSTITUTION:The inside of a concentration tank 11 is maintained at reduced pressure by actuating a decompression device 17, and a raw liquid A is fed to the tray 25 of an uppermost step provided in the concentration tank 11. Far infrared rays radiators 30 are simultaneously heated and while the raw liquid A naturally falls down in multiple trays 25, it is irradiated with far infrared rays. Thereby the water content incorporated in the raw liquid A is evaporated to concentrate it. The concentrated raw liquid A is fed into an ice making machinery 40, frozen and iced and made to a particulate material B to be dried. Then the inside of a vacuum tank 51 is maintained at vacuum by actuating a vacuum exhauster 57 and the frozen particulate material B to be dried is fed to the uppermost conveyor 63 by actuating the conveyor 63. While this particulate material B to be dried is carried by the conveyor 63, it is projected with the far infrared rays fed from far infrared radiators 64, and the water content of the inside is efficiently sublimed and a dried particulate material C is obtained.
The subject invention concerns materials and methods for inhibiting activity of a broad spectrum of viruses in humans and animals. In one embodiment of the invention, a method is provided for treating or preventing viral infection in an animal by administering an effective amount of peptide that is an antagonist of SOCS-I and/or SOCS-3. In a specific embodiment, the peptide corresponds to the activation loop of janus kinase JAK2. In an exemplified embodiment, the peptide has the amino acid sequence: LPQDKEYYKVKEP (pJAK2 (1001-1013)) (SEQ ID NO:1). Compositions contemplated within the scope of the invention include peptides of the invention and optionally one or more other antiviral compounds. Examples of viruses whose replication can be inhibited using the present invention include, but are not limited to, vaccinia virus, EMC virus, influenza virus, and herpes simplex virus. In addition to treating a human or animal having a viral infection, the subject invention can also be used to prevent viral infection in an uninfected human or animal.
Hearing organs develop together with the vestibular system and work with close cooperation. Because of this close neuro-anatomic relationship; cochlear, semicircular canal, or both may cause damage to the vestibular dysfunction, resulting in imbalance. Sensory impairment in children with hearing loss may lead to decreased muscle strength and respiratory function with balance and coordination disorders. Core stabilization is provided anatomically with abdominal muscles at the front, spinal and gluteal muscles at the back, diaphragm at the top and pelvic floor and hip muscles at the bottom. Core stabilization training is a training to increase the strength, endurance and neuromuscular control of the aforementioned muscles.

When the literature is checked, the invetigators find that postural control is being evaluated in children with hearing impairment, but there are few studies evaluating respiratory functions. However, they did not encounter a study in which respiratory muscle strength was assessed in these children. In this study the investigators will examine the effects of core stabilization exercises on respiratory muscle strength, respiratory functions and postural control in hearing-impaired children.
BACKGROUND/AIM: Although nutritional risk factors for developing complications in type 2 diabetes mellitus (T2DM) have been examined, the effect of protein intake on nephropathy is debated, and there is little research on retinopathy. This cross-sectional case-series study aimed to examine the risk factors, including nutritional status, for complications in patients newly diagnosed with T2DM.
PATIENTS AND METHODS: Fifty-four patients were recruited, based on the results of examinations of blood glucose and/or glycated hemoglobin level for T2DM. To evaluate nutritional status, blood and urine examinations were performed and the Food Frequency Questionnaire was administered. Two-way analysis of variance, Fisher's exact test and logistic regression analyses were performed.
RESULTS: The patients were categorized into four groups: 24 without albuminuria and without retinopathy, four without albuminuria with retinopathy, 21 with albuminuria without retinopathy, and five with albuminuria with retinopathy. Logistic analysis of albuminuria revealed that estimated sodium intake was significantly independent as the explanatory factors of age, sex, and body mass index. Patients with retinopathy had significantly higher blood urea nitrogen, and significantly lower plasma total protein levels than patients without retinopathy, suggesting that retinopathy is related to a higher catabolic state. Through a questionnaire on food intake, patients with retinopathy had a significantly lower intake of fat and monounsaturated fatty acids and a significantly higher intake of iodine based on intake of seaweed, corrected for energy intake, than patients without retinopathy.
CONCLUSION: The present study may lead to planning a large cohort study for examining nutritional risk factors related to complications in patients newly diagnosed with T2DM in Japan.
Anal fistulae, defined as an abnormal connection between the distal alimentary tract and the integument, are among the common illnesses affecting the anal canal, with a prevalence rate of 8.6 cases per 100,000.1 Usually, anorectal fistulae are safely and reliably treated by fistulotomy. One of the common complications of fistulotomy is incontinence due to sphincter injury, with an incidence reaching up to 12%2. Moreover, this technique is not well suited for complex anal fistulae due to the prevalent risk of incontinence reaching up to 50%2. That created the need for sphincter sparing procedures to evolve which do not involve division of any portion of the sphincter complex, thus evolvement of an anaesthetic technique which spares the presence of muscle tone, and provides good postoperative analgesia.2,3 The choice of anaesthetic technique for sphincter sparing procedures is challenging. Regional anaesthetic techniques such as saddle, lumbar epidural, and caudal blocks are considered well tolerable and reliable for anorectal surgery. Lumbar epidural local anaesthesia does not produce a uniform anaesthetic effect across the spinal segments as the large size of the L5 and S1 nerve roots may be resistant to the local anaesthetic effect and The cranial spread of lumbar epidural anaesthesia is somewhat more extensive than the caudal spread which suggest that the onset of the block of the caudal sacral segments may be later than that of the lumbar segments. 4On the other hand, saddle anaesthesia is the preferred route for most of the anorectal surgeries as it abolishes the muscle tone5; however, loss of the muscle tone consequently increases the possibility of the external anal sphincter injury in complex anal fistulas. Thus; sphincter sparing procedures are usually performed under general anaesthesia omitting neuromuscular blocking agents in order to preserve sphincter tone intraoperatively.6 However, the choice of general anaesthesia for this procedure still lacks adequate postoperative analgesic plan.

Caudal block is not a commonly used route for analgesia in adults due to the evolution of lumbar epidural block5. The introduction of ultrasound for guiding different blocks, including caudal block had increased the use of caudal block7 especially when sacral nerve spread of anaesthetics is preferred over lumbar nerve spread8. Modern epidural dosing regimens (e.g. 0.0625% to 0.1 % bupivacaine with 2-4 mcg/ml fentanyl) 6,9 reduce the total local anaesthetic dose required and motor block experienced; potentially allowing the patient to be ambulatory.

Therefore, Supplementing general anaesthesia with caudal analgesia in sphincter sparing procedures might be useful as it will provide a satisfactory combination of sphincter muscle tone preservation, good intraoperative and postoperative analgesia along with a reduction in the consumption of opioids and anaesthetic drugs. To the best of our knowledge, this anaesthetic technique was not tested in sphincter sparing procedures before.