anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
To improve the integrity of medical information when transmitting to a terminal the medical information that is shown to the display of a medical device.SOLUTION: A medical system 1 comprises a medical device 10 and a terminal 20. The terminal 20 is capable of transmitting and receiving prescribed data to and from the medical device 10 via a network 5. The medical device 10 includes a first controller 11 and a first display 12. The first controller 11 generates first image data on the basis of medical information acquired by the medical device 10. The first display 12 displays a first image 1G based on the first image data. The first controller 11 generates second image data for displaying the substantially same image as the displayed first image 1G on the terminal 20, in response to a request received from the terminal 20, and transmits the second image data to the terminal 20 via the network 5. Upon receiving the second image data, the terminal 20 displays a second image 2G based on the second image data.SELECTED DRAWING: Figure 1
PURPOSE:The titled application agent capable of being kept in the oral cavity for a long time without being affected by the influence of spittle, absorbing a drug in the gum effectively, obtained by laminating a composition containing a water-soluble or water-swelling high polymer and the drug to a flexible substrate in a sheet form. CONSTITUTION:A composition containing a water-soluble or water-swelling high polymer substance and a drug is laminated to a flexible substrate (e.g., nonwoven fabric, plastic film), to give the titled application agent. A combination of gelatin, agar, etc. having gel-forming ability and polyvinyl alcohol, polyvinyl pyrrolidone, cellulose derivative, etc. having film-forming ability is preferable as the high polymer substance. Not only a remedy for pyorrhea alveolaris, stomatitis, etc. but also nitroglycerin, etc. may be used as the drug. Consequently, it can be used as a preventive for angina pectoris, etc., and the application agent is useful not only for the surroundings of the gum, but also for a preventive and remedy for diseases of the whole body.
Obesity and the associated severe consequences for health, i.e. cardiovascular diseases or Diabetes Type 2 reach the world-wide level of an epidemic with excessive eating as major cause of this development. Study results of veterinary physiology as well as in women let assume that steroid hormones, such as estrogen or progesterone are highly involved in the regulation of eating behavior and the female body weight. This connection is underpinned with the fact that prevalence of adiposity is increased in women in comparison to men in the United States, Switzerland and further countries. A better understanding of the underlying regulatory mechanisms, which in turn influence the food intake in the gut system through the release of satiety hormones as well as through central regulative mechanisms in the brain, provides important foundation in long-term development of new prophylactic and therapeutic options in reduction and prevention of obesity. This gets even more important, as current therapeutic options - beside bariatric surgery - could only show limited success.

Satiety is a process in the brain that leads to a meal being ended, whereby the ingested food causes a reflexive negative feedback mechanism. This mechanism is both fundamentally and specifically in the acute situation strongly influenced through subjective parameters, e.g. eating desires, socio-cultural factors, current social circumstances and individual relation towards eating. Furthermore, food intake is also influenced by genetic factors, whereas e.g. TaqIA1 allele is known to be associated with obesity. According to current knowledge, regulation takes place on peripheral as well as on central level, whereas not only steroid hormones but also satiety hormones - especially cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) - are involved on both levels.

The current study aims to examine the connection of steroid hormones, gastrointestinal satiety hormones and neuronal activity in the brain through fMRI. Through the obtained data, the interaction between defined hormone constellations, gastrointestinal satiety hormones and the activation of specific brain areas in obese and normal-weight women should be evaluated. The study design involves the comparison of subjective, hedonic evaluation of different flavoured liquids with different caloric content each through a rating scale as well as objective peripheral (release of CCK and GLP-1) and central (activation of involved brain centres through fMRI) regulation processes in fasted and fed condition of each woman in the two study groups (obese and normal-weighted) in late follicular compared with the luteal phase of ovarian cycle.
The participants received a 5-minutes acupressure on Sanyinjiao point of both legs per day from 5 days ago of one period untill the third day of the period. The participants received the same intervention in the coming period again.
BACKGROUND: The authors performed a retrospective review to analyze operative outcomes of breast mound reconstruction after robot-assisted mastectomy.
METHODS: Patients who underwent nipple-sparing mastectomy (NSM) with a robotic device (Da Vinci Xi) and immediate prepectoral prosthetic reconstruction by lateral incision from June of 2018 to July of 2019 were enrolled. Patient characteristics, complications, and satisfaction rates as assessed by BREAST-Q were analyzed. The surgical technique was described in detail.
RESULTS: Thirty-nine cases, including 7 bilateral cases (total 46 breasts), underwent robot-assisted NSM followed by immediate prepectoral prosthetic implant reconstruction. The median patient age was 46.63 years (range, 21 to 63 years). The mean operation time for each prepectoral breast mound reconstruction using the direct-to-implant technique was 126.55 minutes. Robot-assisted reconstruction resulted in superior BREAST-Q scores compared with the conventional reconstruction method. Major infection occurred in 7 cases (15.2%), and complete nipple loss occurred in 3 cases (6.6%). Severe complications requiring breast implant removal occurred in 4 breasts (8.7%). Two cases were due to the coexistence of infection and skin necrosis; in 1 case, the skin flap became congested on postoperative day 3 and required additional surgery to change the expander. Other complications were resolved with conservative care or minor revision.
CONCLUSIONS: This report is the first concerning robot-assisted NSM followed by prepectoral acellular dermal matrix-wrapped prosthetic reconstruction. This procedure was not inferior to other methods. Further prospective research to evaluate oncologic outcomes is warranted.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
Pressure controlled ventilation mode and inspiratory pressure was increased every 5cmH2O, until the maximum pressure of 40 cmH2O was reached. The inspiratory time was gradually increased until the inspiratory flow reached the baseline. Concomitantly, the respiratory rate was decreased to allow the expiratory flow also to reach the baseline, to avoid self-PEEP.
The preparation is described of substituted triazenes of general formula <FORM:0893437/IV (b)/1> wherein R is phenyl or halo-phenyl, R1 is hydrogen, C1-6 alkyl, phenyl or halo-phenyl, R2 is phenyl or halo-phenyl, and n is 0 and m is 1 or n is 1 and m is 0 or n and m are both 0.  Compounds of the above formula and which may be represented also by the formula <FORM:0893437/IV (b)/2> wherein R and R1 are phenyl or p-chlorophenyl radicals and R2 is a phenyl or halo-phenyl radical are prepared by reacting a 1,3-diphenyltriazene or 1,3-di-(p-chlorophenyl)-triazene with a phenyl or halophenyl isocyanate.  Specified compounds produced in this way are 1,3-diphenyl-3-phenylcarbamoyltriazene; the 1,3-diphenyl-3-(o, m and p-chlorophenylcarbamoyl)-triazenes and the corresponding p-bromo derivative and 1,3-di-(p-chlorophenyl)-3-phenylcarbamoyltriazene. Compounds of the formula I above which may be represented also by the formula <FORM:0893437/IV (b)/3> wherein R is a C1-6 alkyl radical or a phenyl radical are prepared by the acylation of a 1,3-substituted triazene with, e.g. acetic anhydride, butyric anhydride, acetyl chloride or benzoyl chloride.  Specified compounds thus prepared are: 1,3-diphenyl-3-butyryltriazene and the corresponding benzoyl derivative.  The acetyl and propionyl derivatives are also mentioned. Compounds which may be represented by the formula <FORM:0893437/IV (b)/4> wherein R is hydrogen or a nitro group or halogen atom and R1 is hydrogen or an azophenyl group or halogen atom, are prepared by reacting a primary or secondary amine with a diazotized aromatic amine in neutral or alkaline solution.  The preparation of 1,3-bis-(p-chlorophenyl)-triazene by this method is described.ALSO:Orally and parenterally administrable compositions in unit dosage form for the treatment of malignant growths comprise a solid or liquid carrier and a compound of general formula <FORM:0893437/VI/1> wherein R is phenyl or halophenyl, R1 is hydrogen, C1-6 alkyl, phenyl or halophenyl, R2 is phenyl or p halophenyl, n is 0 and m is 1, or n is 1 and m is 0 or both n and m are 0 or of the general formula <FORM:0893437/VI/2> wherein R is hydrogen or a nitro or halo radical and R1 is hydrogen or an azophenyl or halo radical.  The compositions may be in the form of a tablet, capsule, pill, solution, powder, or an aqueous or oily injection solution.
The invention provides a formula of traditional Chinese medicine for treating gastritis. The traditional Chinese medicine for treating gastritis is prepared from the following medicinal raw materials by weight: 10g of rhizome pinelliae, 3g of coptis chinensis, 10g of scutellaria baicalensis, 15g of codonopsis pilosula, 5g of rhizome zingiberis, 10g of fried fructus aurantii, 15g of hedgehog hide, 30g of radix salviae miltiorrhizae, 15g of trogopterus dung, 15g of dandelion, 10g of parched white peony root and 6g of crude liquorice. The traditional Chinese medicine is mainly used for treating chronic erosive gastritis and antral gastritis and has the treating and nursing functions. The medicine with a unique formula can act on nidi directly and get rid of pathogemetic qi. The natural ingredients of the traditional Chinese medicine contain abundant nutrient substances and therefore can restore broken gastric mucosa and eliminate repeated attack of stomach diseases to ensure low recurrence rate and durable curative effect. The traditional Chinese medicine is made of natural materials, so that the medicine has no toxic or side effects caused by chemical medicines and is safe to take.
Patient with NRS pain at rest being 4 or higher, primarily treated by emergency physician, internist, or surgeon. All patients receive usual care, no interventions are administered.
Frontal fibrosing alopecia (FFA) is a primary cicatricial alopecia characterized by hairline recession, pruritus, and facial papules (FP). Various therapies are used to stabilize disease activity and induce remission. However, FP of FFA is resistant to treatment in many cases. In this review, we searched the PubMed and Google Scholar databases to screen the published literature on treatment options for FP in the context of FFA. Overall, 12 studies were included in this review. Available literature suggests a noticeable improvement in resistant-to-treatment FP in FFA patients with oral isotretinoin. The available evidence is limited and is derived from retrospective studies and case reports/series. Systemic isotretinoin can be considered a promising therapeutic regimen for treating resistant-to-treatment FP of FFA patients. However, more extensive, well-designed studies are necessary for confirmatory evidence.
EnChroma filters are aids designed to improve color vision for anomalous trichromats. Their use is controversial because the results of lab-based assessments of their effectiveness have so far largely failed to agree with positive anecdotal reports. However, the effectiveness of EnChroma filters will vary depending on the conditions of viewing, including whether the stimuli are broadband reflective surfaces or colors presented on RGB displays, whether illumination spectra are broadband or narrowband, the transmission spectra of particular filters, and the cone spectral sensitivity functions of the observer. We created a model of anomalous trichromatic color vision to predict the effects of EnChroma filters on the color signals impaired in anomalous trichromacy. Using the model we varied illumination, filter type and observer cone sensitivity functions, and tested the effect of presenting colors as broadband reflective surfaces or on RGB displays. We also used hyperspectral images to assess the impact of the filters on anomalous trichromats' color vision for natural scenes. Model results predicted that the filters should be broadly effective at enhancing anomalous trichromats' equivalent to L/(L + M) chromatic contrasts under a range of viewing conditions, but are substantially more effective for deuteranomals than for protanomals. The filters are predicted to be more effective for broadband reflective surfaces presented under broadband illuminants than for surfaces presented under narrowband illuminants or for colors presented on RGB displays. Since the potential impacts of contrast adaptation and perceptual learning are not considered in the model, it needs to be empirically validated. Results of empirical tests of the effects of EnChroma filters on deuteranomalous color vision in comparison with model predictions are presented in an accompanying paper (Somers et al., in prep.).
Follitropin alfa, a gonadotropin [human follicle stimulating hormone (hFSH)], is a glycoprotein hormone produced by recombinant DNA technology in a Chinese Hamster Ovary (CHO) cell line. It has a dimeric structure containing two glycoprotein subunits (alpha and beta). The alpha and beta subunits have 92 and 111 amino acids, respectively, and their primary and tertiary structures are indistinguishable from those of human follicle stimulating hormone. The molecular weight is approximately 31 kDa (14 kDa for alpha subunit and 17 kDa for beta subunit).

GONAL-F (follitropin alfa) for injection is a sterile, lyophilized powder intended for subcutaneous injection after reconstitution.

Each multiple-dose vial of GONAL-F containing either 450 International Units (33 mcg) or 1050 International Units (77 mcg) follitropin alfa and the inactive ingredients dibasic sodium phosphate (0.89 mg), monobasic sodium phosphate (0.39 mg), and sucrose (30 mg). Phosphoric acid and/or sodium hydroxide may be used prior to lyophilization for pH adjustment. After reconstitution with supplied 1 mL of with Bacteriostatic Water for Injection (0.9% benzyl alcohol), USP, the resultant concentration is 600 IU/mL with a pH of approximately 6.5 to 7.5.

Under current storage conditions, GONAL-F may contain up to 10% of oxidized follitropin alfa.
Hypertrophic scar (HS) is one of the most common sequelae of patients, especially after burns and trauma. The roles of regulatory long noncoding RNAs (lncRNAs) in mediating HS remain underexplored. Human hypertrophic scar-derived fibroblasts (HSFBs) have been shown to exert more potent promoting effects on extracellular matrix (ECM) accumulation than normal skin-derived fibroblasts (NSFBs) and are associated with enhanced HS formation. The purpose of this study is to search for lncRNAs enriched in HSFBs and investigate their roles and mechanisms. LncRNA MSTRG.59347.16 is one of the most highly expressed lncRNAs in HS detected by lncRNA-seq and qRT-PCR and named as hypertrophic scar fibroblast-associated lncRNA (HSFAS). HSFAS overexpression significantly induces fibroblast proliferation, migration, and myofibroblast trans-differentiation and inhibits apoptosis in HSFBs, while knockdown of HSFAS results in augmented apoptosis and attenuated proliferation, migration, and myofibroblast trans-differentiation of HSFBs. Mechanistically, HSFAS suppresses the expression of A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8). ADAMTS8 knockdown rescues downregulated HSFAS-mediated fibroblast proliferation, migration, myofibroblast trans-differentiation and apoptosis. Thus, our findings uncover a previously unknown lncRNA-dependent regulatory pathway for fibroblast function. Targeted intervention in the HSFAS-ADAMTS8 pathway is a potential therapy for HS.
FIELD: medicine, ophthalmology. SUBSTANCE: the method deals with injection of 15 mg cytochrome C diluted in 5.0 ml physiological solution. Then, 10-15 min before the onset of perfluorane emulsion injection one should carry out premedication including injection of 1.0 ml relanium and 65 mg hydrocortisone. Then, a patient is allowed to breathe with moistened oxygen through a mask at 6 l/min flow rate. After sampling to examine allergic reaction it is necessary to inject 10%-perfluorane emulsion at the quantity of 100 ml. Repeated course of therapy should be carried out in 1-3 d. EFFECT: more stable clinical effect.
E-DYNAMIC clinical decision support (CDS) retrieves near-real time patient data from the electronic health record to help primary care providers identify patients with stage 3-5 CKD, present ASCVD risk, statin use and clinical recommendations for ASCVD risk reduction at point of care. E-DYNAMIC directs referrals to nurses for CKD education and to dietitians for MNT. Providers are also nudged to prescribe statin medications and address hypertension management.
FIELD: biotechnology, food industry. SUBSTANCE: invention relates to novel detected strain of Bacillus species IZP-04 NII KKM GNTS VB "Vector" V-846. Strain grows on different nutrient media at 6-42 C, optimal growth temperature is 22-32 C, cells are gram-positive, they form spores, respiration type is aerobic. Strain shows the expressed antimycotic activity and resistance to tetracycline and levomycetin, it lets sour milk actively for 6-10 h with formation of dense clot with acidity 70-90 T. Prepared fermented-milk foodstuffs show curative-prophylaxis effect in dysbacteriosis. Invention can be used in production of foodstuffs and biopreparations normalizing gastroenteric tract microflora. EFFECT: expanded assortment of strains used as component of ferments for fermented-milk foodstuffs with curative-prophylaxis properties. 3 ex
Intravenous infusion of colistimethate sodium for injection for 7-14 days. Meropenem intravenous infusion once every 8 hours or 12 hours.
<P>PROBLEM TO BE SOLVED: To provide a novel anti-inflammatory agent.  <P>SOLUTION: A composition for treating collagenolytic or inflammatory diseases or disorders comprises a shark cartilage extract as an active ingredient. The shark cartilage extract is a supernatant fraction obtained after centrifugation of an aqueous homogenate of an intact shark cartilage. The fraction is recovered by fractionating the supernatant on a membrane possessing a molecular weight cut-off of 500 kDa. The composition has molecules having molecular weights of <500 kDa and possesses an anti-collagenolytic activity and an anti-inflammatory activity.  <P>COPYRIGHT: (C)2003,JPO
A purification process for large-scale production of Gc-globulin is described. The source of Gc-globulin is preferably a crude plasma fraction but can be any solution, suspension or supernatant containing Gc-globulin, e.g., a milk product, colostrum or a fermentation broth. The Gc-globulin can be plasma-derived or produced by a genetic modified organism. The process includes two key elements: purification by series of ion exchange chromatography steps, and performing at least two virus-reduction steps. A diagnostic method to measure the free Gc-globulin in a patient blood sample, a use of Gc-globulin in medicine and the preparation of a Gc-globulin medicinal product is also provided. The product can be used in therapy for patients with circulatory disorders and complications, i.e., where it is contemplated that said patients would benefit from the administration of Gc-globulin.
Immune checkpoint inhibitor (ICI)-based combination therapies are the recommended first-line treatment for metastatic renal cell carcinoma (mRCC). However, no head-to-head phase-3 randomized controlled trials (RCTs) have compared the efficacy of different ICI-based combination therapies. Here, we compared the efficacy of various first-line ICI-based combination therapies in patients with mRCC using updated survival data from phase-3 RCTs. Three databases were searched in June 2023 for RCTs that analyzed oncologic outcomes in mRCC patients treated with ICI-based combination therapies as first-line treatment. A network meta-analysis compared outcomes including overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and complete response (CR) rate. Subgroup analyses were based on the International mRCC Database Consortium risk classification. The treatment ranking analysis of the entire cohort showed that nivolumab + cabozantinib (81%) had the highest likelihood of improving OS, followed by nivolumab + ipilimumab (75%); pembrolizumab + lenvatinib had the highest likelihood of improving PFS (99%), ORR (97%), and CR (86%). These results remained valid even when the analysis was limited to patients with intermediate/poor risk, except that nivolumab + ipilimumab had the highest likelihood of achieving CR (100%). Further, OS benefits of ICI doublets were not inferior to those of ICI + tyrosine kinase inhibitor combinations. Recommendation of combination therapies with ICIs and/or tyrosine kinase inhibitors based on survival benefits and patient pretreatment risk classification will help advance personalized medicine for mRCC.
PURPOSE: To explore the incidence of postoperative acute kidney injury (AKI) after coronary artery bypass grafting (CABG) in elderly Chinese patients (≥ 75 years old) and its impacts on the short- and long-term prognosis.
METHODS: A total of 493 patients aged 75-88 years old who underwent CABG from two medical centers between January 2006 and October 2021 were involved. Perioperative (preoperative and 7 days after operation) serum creatinine (Scr) levels were measured in all the enrolled patients. Univariate and multivariate logistic regression analyses were conducted to explore the independent risk factors of postoperative in-hospital mortality. Kaplan-Meier curves and COX model were used to test the risk factors of all-cause death during follow-up. Propensity score matching was used to balance differences between AKI and control groups. The primary outcome event was in-hospital death, and the secondary outcome was all-cause death during follow-up.
RESULTS: The 198 patients were diagnosed with postoperative AKI. Intra-aortic balloon pump (IABP), cardiopulmonary bypass, and postoperative AKI were independent risk factors of in-hospital death. Gender, New York Heart Association Classification, preoperative eGFR, last eGFR within 7 days after operation, postoperative AKI, and postoperative renal function all impacted long-term prognosis. After 1:1 matching, 190 patients were included in the AKI and control groups. Use of IABP, use of cardiopulmonary bypass, and occurrence of postoperative AKI were still independent risk factors of in-hospital death. Preoperative eGFR, last eGFR within 7 days after operation, postoperative AKI and postoperative renal function all impacted long-term prognosis.
CONCLUSION: The incidence of postoperative AKI in elderly patients undergoing CABG is high, and postoperative AKI is an independent risk factor of both short- and long-term postoperative prognosis.