anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients will receive an axillary block using an ultrasound-guided technique. After skin infiltration with 1 mL of 2% lidocaine, a 22-gauge insulated needle is advanced in-plane from the cephalic aspect of the transducer toward the posterior aspect of the axillary artery. Prior to injection, the syringe is aspirated to confirm extra-vascular placement of the needle. 20 mL solution of 0.5% ropivicaine is then injected slowly, with syringe aspiration after every 5 mL injection to confirm extravascular placement.
The present invention relates to methods and pharmaceutical compositions for the treatment of heart failure. Despite current available treatments, heart failure remains associated with high morbidity and mortality.  In vitro , the inventors showed that PIKfyve is critical for the control of mitochondrial fragmentation, hypertrophic and apoptotic responses to stress. They also provide evidence that inactivation of PIKfyve by the selective inhibitor STA-5326 suppresses excessive mitochondrial ROS production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.  In vivo , the inventors showed that inhibition of PIKfyve improves cardiac function on two mouse models (high-fat-diet mice and pressure overload-induced heart failure mice). In particular, the present invention relates to PIKfyve inhibitors for treating heart failure in a subject in need thereof. Particularly, the inventors tested STA-5326, a PIKfyve inhibitor, on both  in vitro  and  in vivo  models.
PURPOSE:To provide the titled contrasting agent introducible into a lymphatic system without using celiotomic operation and useful in the medical field, by suing fine particles of a substance having a radiolucency different from human body and dispersing the particles in a liquid. CONSTITUTION:Fine particles of a substance having a radiolucency different from human body (e.g. silver particles, metallic iodine, barium sulfate, polymeric substance, etc.) are dispersed in a liquid (a liquid having low viscosity, e.g. water, physiological saline water, Ringer's solution, etc.) and the dispersion is used as the objective contrasting agent for lymphatic system. The diameter of the fine particle is usually <=40mu. The obtained contrasting agent has lymph- orienting property in itself, migrates automatically into the peripheral lymph by the injection into the celom to be contrasted and is taken into the lymphatic system. Accordingly, contrasting of the lymphatic system can be carried out without using surgical operation.
Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic-pituitary-gonadal (HPG) axis. The association between MKRN3 gene variants and central precocious puberty (CPP) has been repeatedly examined. In a recent study, MKRN3 has been assigned a role of tumor suppressor in lung carcinogenesis. Therefore, it is hypothesized that MKRN3 may be the link between CPP and lung cancer (LC), and certain MKRN3 gene variants may affect individuals' susceptibility to CPP and LC. The rs12441287, rs6576457 and rs2239669 in the MKRN3 gene were selected as the target variants. Sanger sequencing was applied to genotype them in two sets of case-control cohorts, namely 384 CPP girls and 422 healthy girls, 550 LC patients and 800 healthy controls. The results showed that rs6576457 but not rs12441287 or rs2239669 was significantly associated with the risk of CPP and LC. Their association with CPP risk was further confirmed in the following meta-analysis. Subsequent functional assays revealed that the rs6576457 genotypes were correlated with differentially expressed MKRN3, and the rs6576457 alleles affected the transcription repressor Oct-1 binding affinity to the MKRN3 promoter. Collectively, the MKRN3 gene rs6576457 may participate in the CPP pathology and LC tumorigenesis in the Hubei Chinese population. However, the present findings should be validated in additional investigations with larger samples from different ethnic populations.
An instrument for extraction and separation of extraction solution of an aromatic tree and a method of manufacturing the same are provided to provide a medical material without side effects. An instrument for extraction and separation of extraction solution of an aromatic tree includes a steam heating tank(10), a steam pipe(16), a connection pipe(14), a cooling tank(20), and an oil and water separator(30). The steam heating tank accommodates leaves and stems of the aromatic tree. The steam pipe is connected to a lower part of the steam heating tank to heat the leaves and stems by ejecting steam. The steam generated from the steam pipe is moved through the connection pipe to arrive at the cooling tank. The steam condensed by the cooling water is converted into liquid to form extraction materials. At this time, since oil is contained in the extraction material, the oil is separated from the extraction material to generate purified oil by the oil and water separator.
Subjects followed a muscle power training for 8 weeks (2 sessions per week on alternate days) using the leg extension exercise, with similar relative intensity (50% 1RM). Between weeks one and four two series will be performed per session. Then the number of series will increase to three per session. The inter-set recovery period will be always of 2-min. Velocity loss will be of 10% (VL10) in each set.
The invention relates to a liquefied semen conditioning pill. The invention adopts the solution that: the principle of the Chinese medicine on treating sterility, namely nourishing yin and supplementing the kidney, and clearing away fever and eliminating phlegm, is based. The liquefied semen conditioning pill is formed according to the principle, and adopts the method of both invigorating the kidney and eliminating the phlegm to achieve the aim of treating an illness. The liquefied semen conditioning pill is a traditional Chinese medicine pill prepared by mixing the following raw materials: dried rehmannia rhizome, talcum, prepared rehmannia rhizome, dwarf lilyturf roots, oysters, fried atractylis ovata, glossy privet fruit, liquorice, Chinese yam, phellodendron, giant knotweed, Dangshen, poria cocos, salvia miltiorrhiza, raw coix seeds, dragon bones, dandelion and endothelium corneum gigeriae galli. The liquefied semen conditioning pill can effectively treat sterility caused by various reasons, and particularly has high cure and healing effects on sterility caused by incapability of liquefaction of semen, low survival rate of sperms, low number of the sperms, a plurality of self cells, and varicocele. The liquefied semen conditioning pill is convenient to take and has low medicine cost and short treatment period, and the healing effect can be shown after one treatment period generally.
After intravenous administration, fluoride F18 ion is rapidly cleared from the plasma in a biexponential manner. The first phase has a half-life of 0.4 h, and the second phase has a half-life of 2.6 h. Essentially all the fluoride F18 that is delivered to bone by the blood is retained in the bone. One hour after administration of fluoride, F18 only about 10% of the injected dose remains in the blood. Fluoride F18 diffuses through capillaries into bone extracellular fluid space, where it becomes bound by chemisorption at the surface of bone crystals, preferentially at sites of newly mineralizing bone.

Deposition of fluoride F18 in bone appears to be primarily a function of blood flow to the bone and the efficiency of the bone in extracting the fluoride F18. Fluoride F18 does not appear to be bound to serum proteins.

In patients with normal renal function, 20% or more of the fluorine ion is cleared from the body in the urine within the first 2 hours after intravenous administration.
FIELD: medicine, phytotherapy, pharmacy. SUBSTANCE: invention relates to parapharmaceutical industry producing preparations of curative and prophylactic designation. The preparation comprises Saint-John's-wort herb processing product, magnesium asparaginate as a magnesium compound, dry concentrate of rosewort extract, dry concentrate of coffee decoction, flower pollen, cacao, citric acid, starch, wheat bran, calcium stearate and sugar. The supplement reduces or eliminates nervopsychic stress, fear and anxiety. EFFECT: valuable medicinal properties of supplement. 1 tbl, 4 ex
Couples in the intervention group will receive two group health education sessions (one during pregnancy and one postpartum) covering information on pregnancy and postpartum health, as well as three couple counseling visits (one during pregnancy and two postpartum). The couples counseling sessions will provide (1) information on key relationship topics (communication, trust and respect, love and support); (2) relationship skills exercises (role playing); and (3) the opportunity to discuss health and relationship priorities/goals of the couple.
Inflammatory state in a subject is assayed by determining the level of expression of A 3  adenosine receptor (A 3 AR) in white blood cells (WBC), e.g. circulating WBCs, from the subject. A high level of expression of A 3 AR is indicative of an inflammatory state in the subject. This assay can be used for determining whether a patient known to have an inflammatory state should be treated with an A 3 AR agonist to reduce the inflammatory state. The patient will be so treated only if the level of A 3 AR in the WBC of the subject is above a predefined threshold, which is about twice the level of A 3 AR in WBC of healthy subjects. The inflammatory state may particularly be rheumatoid arthritis or uveitis.
The self-help app will deliver 12 modules that will be based on Chris Fairburn's "Overcoming Binge Eating" self-help book, the most widely used self-help resource for binge eating. Treatment modules will aim to 1) provide psychoeducation on maintenance factors for binge eating, 2) teach CBT skills designed to interrupt these maintenance factors, and 3) coach participants to set personalized goals each week. Modules will be completed in succession over the course of 12 weeks and a new module will be made open each week. At the end of each weekly module, participants will complete an end-of-the-week survey and report on the frequency of skills use in the past week. In addition, participants will track their eating and eating disorder behaviors using the self-help app.
The present invention provides methods of identifying polypeptides that have enzymatic activity associated with nutrient and/or energy homeostasis, and thus, are involved in the development of one or more cardiovascular and metabolic disorders, e.g., cardiovascular disease, obesity, insulin resistance, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease, and metabolic syndrome. One such method comprises identifying a polypeptide as a member of the adiponutrin family of proteins. As such, the invention is related to the polynucleotides and polypeptides belonging to the adiponutrin family, and provides novel isolated and purified polynucleotides and polypeptides of a novel member of the adiponutrin family, patatin-like phospholipase domain 1 (PNPLA1). Also provided are methods of using the polynucleotides and polypeptides related to or provided by the invention for screening a test compound, e.g., a small molecule, antibody, etc., for the ability of the test compound to detect and/or modulate the activity of one or more members of the adiponutrin family of proteins. The present invention also is directed to novel methods for diagnosing, prognosing, and monitoring the progress of at least one cardiovascular and metabolic disorder using polynucleotides or polypeptides belonging to the adiponutrin family, and/or modulators of one or more members of the adiponutrin family. The present invention is further directed to novel therapeutics and therapeutic targets for the intervention (treatment) and prevention of cardiovascular and metabolic disorders arising from dysregulated energy homeostasis, as related to one or more members of the adiponutrin family of proteins.
BACKGROUND: Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis and progression. However, the role of circGLIS3 (hsa_circ_0002874) in prostate cancer (PCa) has yet not been reported.
METHODS: Candidate circRNA were determined through comprehensive analysis of public datasets, PCa cell lines, and tissues data. A series of cellular functional assays, including CCK-8, colony formation, wound healing, and transwell assays were performed. Subsequently, RNA sequencing, RNA immunoprecipitation, methylated RNA immunoprecipitation, microRNA pulldown, luciferase reporter assay, and western blot were used to explore the underlying molecular mechanisms. Moreover, the xenograft tumor mouse model was established to elucidate the function of circGLIS3.
RESULTS: CircGLIS3, derived from exon 2 of the parental GLIS3 gene, was identified as a novel oncogenic circRNA in PCa that was closely associated with the biochemical recurrence. Its expression levels were upregulated in PCa tissues and cell lines as well as enzalutamide high-resistant cells. The cellular functional assays revealed that circGLIS3 promoted PCa cell proliferation, migration, and invasion. METTL3-mediated N6-methyladenosine (m6A) modification maintained its upregulation by enhancing its stability. Mechanically, CircGLIS3 sponged miR-661 to upregulate MDM2, thus regulating the p53 signaling pathway to promote cell proliferation, migration, and invasion. Furthermore, in vitro and in vivo experiments, the knockdown of circGLIS3 improved the response of PCa cells to ARSI therapies such as enzalutamide.
CONCLUSIONS: METTL3-mediated m6A modification of circGLIS3 regulates the p53 signaling pathway via the miR-661/MDM2 axis, thereby facilitating PCa progression. Meanwhile, this study unveils a promising potential target for ARSI therapy for PCa.
The present invention relates to an anti-ageing body-building medicine for treating spleen-kidney yang deficiency and a preparation method thereof. The anti-ageing body-building medicine comprises hairy antler, prepared fleeceflower root, sea horse, turtle shell (prepared from vinegar), red ginseng, medicinal indianmulberry root (prepared from salt), indian buead, yam, chrysanthemum, chicken gizzard membrane, donkey-hide glue, Chinese eaglewood, mongolian dandelion herb, epimedium herb, songaria cynomorium herb and pangolin (prepared from salt) in certain weight mixture ratio. The anti-ageing body-building medicine is reasonably prepared on the basis of sucking the beneficial conditions of other medicine by the basic functions of kidney warming and spleen strengthening. The anti-ageing body-building medicine has the effects of nourishing, strengthening and life prolonging. The medicine combines the medicine so that yin and yang are complemented, qi and blood are sufficient, and the viscera has complete functions. The effects of yin and yang smoothness, pathogenic factor elimination, ageing resistance and life prolonging are achieved. The whole preparation has tight match of twenty kinds of medicine and no dissociation, the beneficial conditions of the medicine can be performed, and the medicine can be cooperated and supplemented so that yin and yang blood can be collected. The anti-ageing body-building medicine complements viscera channels and strengthens the muscle and bones, the anti-ageing body-building medicine mainly has the effect on regulating and invigorating the yin and yang of the kidney. The medicine can obviously enhance the hypoxia resistant capability of a mouse according to a pharmacodynamics experiment and can obviously enhance the total quantity of white cells of the mouse.
PURPOSE:To obtain a coated soft capsule for preventing mutual adhesion of soft capsules and adhesion of a soft capsule to a container, etc., even under a high-temperature high-humidity condition, maintaining transparency of a coating film. CONSTITUTION:This soft capsule has the surface of a coating film transparently coated with a hydroxyalkyl-substituted cellulose (e.g. hydroxypropylmethyl cellulose) and/or a polyvinyl acetal-based polymer (e.g. polyvinyl acetal diethylaminoacetate). The coated amount of the polymer is 0.01-10 pts.wt., especially 0.05-1 pt.wt. based on 100 pts.wt. of the coating film of the soft capsule. The coated soft capsule, for example, is preferably produced by rolling soft capsules by a pan type or a centrifugal fluidity type coating machine, sprinkling or spraying the solution of the coating agent on the soft capsules, drying while intermittently rolling and repeating these operations.
Established risk factors for osteoarthritis (OA) include obesity, joint injury, age, race, and genetics. However, the relationship between cigarette smoking and OA has yet to be established. In the present study, we have employed the use of cigarette smoke extract (CSE), the water-soluble vapor phase of cigarette smoke, with porcine cartilage explants to investigate the effects of cigarette smoking on cartilage catabolism at the tissue level. Articular cartilage explants were first exposed to 2.5%, 5%, and 10% CSE to assess its effects on cartilage homeostasis. Following, the effects of CSE on OA-like inflammation was observed by culturing explants with a combined treatment of IL-1β and TNF-α and 10% CSE (CSE + OA). Cartilage explants were assessed for changes in viability, biochemical composition, extracellular matrix (ECM) integrity, and equilibrium mechanical properties (aggregate modulus and hydraulic permeability). CSE alone leads to both a time- and dose-dependent decrease in chondrocyte viability but does not significantly affect sGAG content, percent sGAG loss, or the ECM integrity of cartilage explants. When IL-1β and TNF-α were combined with 10% CSE, this led to a synergistic effect with more significant losses in viability, significantly more sGAG loss, and significantly higher production of ROS than OA-like inflammation only. Cartilage explant equilibrium mechanical properties were unaffected. Within the timeframe of this study, CSE alone does not cause OA but when combined with OA-like inflammation leads to worsened articular cartilage degeneration as measured by chondrocyte viability, sGAG loss, proteoglycan staining, and ROS production.
Disclosed is a reverse-cellular senescence inducing method that uses a specific molecular target to revert senescent cells to a young cell state. Specifically, the present invention relates to a reverse-cellular senescence inducing composition comprising a PDK1 (phosphoinositide-dependent kinase-1) inhibitor or a reverse-cellular senescence inducing method comprising applying the PDK1 inhibitor. The PDK1 is a protein that regulates both mTOR and NF-kB, which are key signaling proteins involved in the cellular senescence. Thus, the PDK1 is a key protein that determines growth, division and a senescence associated secretory phenotype (SASP) of cells. Temporary inhibition of the PDK1 effectively reverses senescent cells into normal young cells. A phenotype of the senescent cells is no longer observed in the reversed cells. Thus, the PDK1 opens up new possibilities for current aging treatment strategies, which have focused on inducing apoptosis of senescent cells. The PDK1 may be usefully used in development of anti-aging substances and an agent for treating age-related diseases.
Forecasts of infectious agents provide public health officials advanced warning about the intensity and timing of the spread of disease. Past work has found that accuracy and calibration of forecasts is weakest when attempting to predict an epidemic peak. Forecasts from a mechanistic model would be improved if there existed accurate information about the timing and intensity of an epidemic. We presented 3000 humans with simulated surveillance data about the number of incident hospitalizations from a current and two past seasons, and asked that they predict the peak time and intensity of the underlying epidemic. We found that in comparison to two control models, a model including human judgment produced more accurate forecasts of peak time and intensity of hospitalizations during an epidemic. Chimeric models have the potential to improve our ability to predict targets of public health interest which may in turn reduce infectious disease burden.
PROBLEM TO BE SOLVED: To obtain a food composition synergistically accelerating beauty white effect and having both of sufficient beauty white effect and safety by peroral ingestion by including proanthocyanidin and glutathione. SOLUTION: This food composition contains (A) proanthocyanidin and (B) glutathione. As the component A, e.g. an extract of seeds of grapes is used. Preferably, an extract, etc., of glutathione-containing yeast powder, a glutathione-containing lever of a bovine or a swine is used. Preferably, a collagen or a degraded collagen is further mixed to the objective composition because of exceedingly synergistically accelerating beauty white effect of the skin. Preferably, each component is mixed to the objective composition so as to contain 50-200 mg of the component A, 100 μg-10 mg of the component B and 100 mg-5 g of collagen (degraded material) per a daily ingestion amount of the objective composition.
Periodontally healthy individuals in the control group had an intact periodontium or a reduced periodontium (without detectable interproximal clinical attachment loss or radiographic bone loss) in a non-periodontitis patient. In this group, probing depth was ≤ 3 mm and bleeding on probing was \< 10 % in the whole mouth.
Low-grade glioma is a malignant tumor of young adults (12.5% of gliomas, incidence of 0.99 / 100,000). Median survival, linked to anaplastic transformation is estimated between 7 and 10 years, with great individual variability in the rate of evolution. The morphological MRI, standard assessment tool at present, suffers from many limitations, especially concerning the positive diagnosis, the targeting of surgical biopsies and tumor delineation which is essential to treatment The study design is a validation study of a new diagnostic procedure. This study is prospective, no randomized, multicenter involving 10 centers (Toulouse University Hospital, Caen, Tours, AP-HP Pitie Salpetriere, Lille, Angers, Rennes, Nîmes, Nantes and Nancy). Will be eligible patients in whom the diagnosis of grade II glioma is suspected according to clinical data and MRI, after evaluation and multidisciplinary meeting at which histological confirmation is scheduled within a maximum period of one month.

FET PET scans will be performed before any procedure or surgical treatment and the data will be merged with MRI. The gold standard is histological examination or biopsy material, or complete resection of the tumor. A minimum of three biopsies per patient will be realized. The pathologist will not see the results of PET-FET 100 patients will be enrolled over a period of 5 years. The area under the curve will be determined on a non-parametric for each increase in the value of PET-FET at near 10th. The sensitivities, specificities, positive predictive values will be estimated with confidence intervals at 95%. Factors to be considered in the analysis, the intrasubject variability related to the fact that several positive and negative results are found for each subject included. The concordance between the data-FET PET and MRI will be sought.

The expected benefits are a better diagnostic ability of PET-FET which results in a specific targeting of biopsies with fewer tests to false negatives and false positives, thus a better diagnostic yield of this invasive procedure. Furthermore, the characteristics of this test applied to all of the tumor may help to better define the limit between healthy and tumor areas and thus reduce the radiation fields to the volumes strictly necessary. These volumes are currently defined on the results of the only morphological MRI and can be further clarified