anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This trial will be a multi-center, double blind, placebo-controlled, randomized clinical trial. All mothers identified with prolonged rupture of membranes and/or oligohydramnios, and all inborn infants \< 30 weeks gestational age (GA) at birth will be screened for enrollment. Infants who meet all inclusion and exclusion criteria within the first 48 hours after birth will be randomized to either inhaled NO starting at 20 ppm, or matched placebo, delivered by means of a blinded INOvent® delivery device. Randomization will be stratified by center and treatment will be assigned using an interactive voice or web-based response system (IVRS). All infants will receive up to 14 days of therapy, following a dose reduction schedule. The primary outcome measure will be change in oxygenation at 1 hour after start of therapy. In order to determine the effects of iNO therapy on survival and need for mechanical ventilation, cross-over will not be allowed.

This clinical trial will attempt to demonstrate if pre-term infants may benefit from treatment with nitric oxide for inhalation. A multi-center study is necessary to recruit an appropriate number of subjects, and to reflect the variability of standard practice across the different participating centers. All treatment assignments are blinded in order to minimize the risk of bias in treatment and data collection. In addition, a concurrent placebo group has been chosen as the most appropriate control group since there may be temporal, institutional and national variations in average outcomes. Methemoglobin levels will be measured locally and will collected in a blinded manner.
PURPOSE:To enable easy continuous manufacture having no dispersion of effective components by forming a film of a soluble arginic salt aqueous solution, spraying a soluble calcium salt aqueous solution to this film, and gelling the film of said aqueous solution, and forming a gelled film. CONSTITUTION:An arginic acid salt is dissolved in water to form an aqueous solution. This solution is adjusted to have a viscosity within the range of several hundreds to several ten thousands cps so that a film can be formed by general coating method. Separately to this, an aqueous solution of soluble calcium salt is prepared. This is adjusted in such a manner that the quantity of the contained calcium ion is preferably 0.2 to 0.35 moles per mole of Na ion contained in the sodium arginate aqueous solution. The concentration of the soluble calcium salt aqueous solution is preferably 1 to 20wt.%. Then the soluble arginate aqueous solution is spread on a base film to form a film, to which the soluble calcium salt aqueous solution is sprayed. Gelling occurs simultaneously with spraying, so that the water-containing arginic film can be continuously produced at high efficiency.
Disclosed are a device for deriving a body fat percentage index using a volume calculation model and a method thereof. The device is a device for deriving the body fat percentage index of a user. The body index acquisition part of the device acquires the body index of a user. A volume calculation modeling part includes a volume calculation model used in dividing a human body into a plurality of parts, setting figures corresponding respectively to the divided parts, applying the body index to each of the set figures to calculate the volume of each of the figures, and summing the volumes of the figures to calculate the volume of the human body. A body fat percentage calculation part applies the body index of a user, which is acquired by the body index acquisition part, to the volume calculation model of the volume calculation modeling part to calculate the body volume of the user, calculates the body fat percentage index of the user, and determines obesity corresponding to the calculated body fat percentage index. Therefore, provided are a device for deriving a body fat percentage index using a volume calculation model and a method thereof, wherein obesity can be measured accurately at a low cost.
FIELD: medicine, particularly, oncology. SUBSTANCE: method includes operation for removal of tumor with resection of facial nerve trunk and its branches. Upon elapse of 7-10 days after operation and removal of sutures exposed to radiotherapy with 6.3 MeV fast neutrons is bed of removed tumor with single dose of 1.4-2.0 Gy and day doses of 8.0-11.0 Gy. Single dose is administered by two fractions a week. Photon-equivalent dose for 30-40 days is 40-45 Gy. EFFECT: higher efficiency of treatment. 1 tbl, 3 ex
Mathematics is a key school subject for some of the most lucrative and economically important careers. Low mathematics performance in school is associated with low psychometric intelligence, family socioeconomic status (SES), specific mathematical abilities, and high mathematics anxiety. We used a sample of Hungarian schoolchildren (N = 102, mean age = 12.3 years) to directly compare the predictive power of general intelligence, specific mathematical abilities measured by the Pedagogical Examination of Dyscalculia (DPV), mathematics anxiety, and socioeconomic status for mathematics grades. Mathematics grades correlated with IQ, specific mathematic ability, mathematics anxiety, and a composite measure of family SES. The WISC-IV showcased a manifest correlation of 0.62 and a latent correlation of 0.78 with the DPV and high manifest (r=-0.53) and latent (r=-0.59) correlations with mathematics anxiety. IQ alone accounted for 52% of the variance in mathematics grades. IQ, specific mathematical ability, family SES and mathematics anxiety jointly accounted for 56% of the variance in grades, with a non-significant contribution of specific mathematical ability and family SES over IQ and a marginal contribution of mathematics anxiety. Our results show that psychometric intelligence is the most important predictor of mathematics grades, while family SES and specific mathematical abilities are only associated with grades to the extent they reflect psychometric intelligence. The results, however, confirmed a small role of mathematics anxiety over intelligence in predicting grades.
It is well known that the price of a given food affects the amount of that item individuals will purchase. Yet little is known about how specific groups, such as obese/overweight individuals and those with lower incomes, change their food purchasing decisions depending on food price changes. Evidence shows that these groups have lower quality diets and worse health outcomes than their normal weight and higher income counterparts. Therefore, it is important to gain a better understanding of how food price changes affect purchasing decisions among these population groups in order to develop targeted nutrition interventions to improve their diet quality. To investigate this, the researchers will create a laboratory-based grocery store, in which pictures of foods will be used in lieu of actual foods. Food prices will be indicated on each picture. The participants will be given play money and a budget, and asked to "purchase" foods in the mock grocery store. The price of foods will be changed throughout the study to investigate how participants change their purchasing decisions based on these price changes.
Patient (from 3 to 17 years-old) treated for appendicular peritonitis. It includes surgical treatment (appendicectomy, peritoneal toilet) and antibiotherapy according to French recommendation.
Some older people experience memory loss that is worse than other people of their age, although they are not demented. This condition is known as mild cognitive impairment (MCI). Healthy older people can learn mnemonic strategies to improve their memory abilities. Can cognitive rehabilitation help people with MCI do better on mental tasks or maintain better functioning in everyday life? This study will evaluate the effects of two different rehabilitation programmes. Patients in the memory training group will learn mental strategies aimed at improving memory. Patients in the memory compensation group will learn to use external memory aids.
BACKGROUND: Digital health applications (DiGA) were included in the German healthcare system in 2020. They are available for prescription and reimbursed by public and private insurance companies. For the specialty of urology, there are currently two DiGA available: for the treatment of erectile dysfunction and benign prostatic hyperplasia/overactive bladder (BPH/OAB). The legal basis, clinical results and practical implementation are presented.
METHODS: Evaluation of websites and publications to show the regulatory requirements, mode of action, results of clinical trials and prescribing practice with DiGA.
RESULTS: Since 2020, 63 DiGA have been listed in the register of the Federal Office for Drugs and Medical Devices (BfArM), 35 of them definitively. Two urological DiGA aim to treat erectile dysfunction and BPH/OAB. Randomized, controlled studies have shown a significant and clinically relevant patient benefit for both DiGA. Further urological DiGA are in clinical development.
CONCLUSIONS: DiGAs offer multimodal therapy combinations that have not yet been used in clinical practice and show a multidimensional benefit for the patient.
Obesity and asthma are the most common diseases of childhood, causing activity limitation and impaired quality of life. Most obese asthmatic children report dyspnea on exertion (DOE) as their primary asthma symptom. Fear of dyspnea promotes sedentariness and reduces exercise capacity and quality of life. DOE in asthmatic children is typically attributed to bronchoconstriction but it is also possible that obesity is an equal or even major contributor to dyspnea. Excess chest and abdominal weight in obese children results in low lung volumes, which increases the risk of mechanical ventilatory constraints such as expiratory flow limitation, dynamic hyperinflation, and airway closure, all of which can provoke DOE. Unnecessary use of corticosteroids and other asthmatic medication in obese asthmatic children cannot treat obesity-specific mechanical ventilatory constraints and could have unintended deleterious effects. Therefore, there is an urgent need to better understand the mechanisms involved in DOE to provide evidence-based symptom management for obese asthmatic children that will promote regular physical activity and lessen DOE.

The overall objective of this study is to better understand the respiratory mechanisms provoking DOE in obese asthmatic children. The investigators hypothesize that low lung volume breathing in obesity leads to mechanical ventilatory constraints in the presence or absence of bronchoconstriction during exercise. Whereas DOE attributable to bronchoconstriction should respond to bronchodilators, DOE attributable to obesity-specific mechanical ventilatory constraints will not respond to bronchodilators. A comprehensive physiological pulmonary function and exercise-testing based approach will be used to identify 9-17-year-old obese asthmatic children who do and do not bronchoconstrict during exercise. The presence/absence of bronchoconstriction will be determined by a comprehensive measure of exercise-induced central and peripheral airway reactivity using spirometry and impulse oscillometry (i.e., greater than or equal to 10% reduction in forced expiratory volume in 1s, FEV1, or greater than or equal to 40% increase in peripheral airway resistance, R5-20, will be indicative of bronchoconstriction). The investigators will also determine the mechanisms by which bronchodilators like albuterol affect bronchoconstriction amd mechanical ventilatory constraints in asthmatic children with obesity.
FIELD: organic chemistry; pharmaceutics. SUBSTANCE: green needles of fir-tree are dried, comminuted and extracted with organic solvent, the latter is constituted by mixture of petroleum ether and ethylacetate. Extract is treated with aqueous alkaline solution, and resulting mixture is maintained until it becomes separated into solid residue and aqueous phase having pH = 7-8. Then aqueous phase is separated and dried to obtain powder. EFFECT: higher effective biopreparation of vegetable origin. 2 tbl
BACKGROUND AND OBJECTIVES: There are very limited data on the rate of urinary tract infections (UTI), bacteremia, and meningitis in preterm infants with fever. Many of the studies on the incidence of these infections excluded preterm infants. This study compared the rate of these infections in preterm infants born at 32-36 weeks to term infants born at 37-42 weeks.
METHODS: A multicenter observational cohort study was conducted to evaluate rates of UTI, bacteremia, and meningitis in term and preterm infants 8-60 days of age with a diagnosis of fever from 2016 through 2022 using encounter data from children's hospitals in the Pediatric Health Information System.
RESULTS: There were 19 507 total febrile infants identified, of which 2162 were preterm and 17 345 were term. Preterm infants had a lower rate of UTI than term infants (1.8% confidence interval [CI] [1.3-2.5] vs 3.0% CI [2.7-3.2], P = .001). Preterm and term infants did not have statistically different rates of bacteremia (1.5% CI [1.3-1.7] vs 1.2% CI [0.8-1.8], P = .44) or meningitis (0.16% CI [0.1-0.2] vs 0.05% CI [0-0.2], P = .36).
CONCLUSIONS: There was no difference in the rate of bacteremia or meningitis between term and preterm infants in a large multicenter cohort of febrile infants. Preterm infants had a lower rate of UTI than term infants. This is the first multicenter study to compare UTI, bacteremia, and meningitis between term and preterm febrile infants.
The objective of this study was to investigate if delivering multiple doses of N-acetylcysteine (NAC) post-surgery in addition to pre-incisional administration significantly impacts the wound healing process in a rat model. Full-thickness skin incisions were carried out on the dorsum of 24 Sprague-Dawley rats in six locations. Fifteen minutes prior to the incision, half of the sites were treated with a control solution, with the wounds on the contralateral side treated with solutions containing 0.015%, 0.03% and 0.045% of NAC. In the case of the NAC treated group, further injections were given every 8 h for three days. On days 3, 7, 14 and 60 post-op, rats were sacrificed to gather material for the histological analysis, which included histomorphometry, collagen fiber organization analysis, immunohistochemistry and Abramov scale scoring. It was determined that scars treated with 0.015% NAC had significantly lower reepithelization than the control at day 60 post-op (p = 0.0018). Scars treated with 0.045% NAC had a significantly lower collagen fiber variance compared to 0.015% NAC at day 14 post-op (p = 0.02 and p = 0.04) and a lower mean scar width than the control at day 60 post-op (p = 0.0354 and p = 0.0224). No significant differences in the recruitment of immune cells and histological parameters were found. The results point to a limited efficacy of multiple NAC injections post-surgery in wound healing.
OBJECTIVE: This systematic review evaluates the efficacy and morbidity of transnasal endoscopic nasopharyngectomy as a salvage treatment for advanced-stage recurrent nasopharyngeal carcinoma (rNPC).
METHODS: Following PRISMA guidelines, we conducted a systematic search in Medline, Scopus, and PubMed, identifying studies on transnasal endoscopic nasopharyngectomy for rNPC. Inclusion criteria encompassed histologically confirmed rT3 and rT4 NPC patients previously treated with radiotherapy or chemoradiotherapy. Data on overall survival (OS), disease-free survival (DFS), and complications were extracted and analyzed.
RESULTS: Nine studies, including a total of 429 patients, met the inclusion criteria. Five studies reported 2-year overall survival (OS) rates ranging from 34.6 % to 88.7 %. Three studies reported 3-year OS rates between 50 % and 63.5 %. Long-term 5-year survival varied widely from 0 % to 100 % across three studies. One study detailed 1-year disease-free survival (DFS) and OS at 93 % and 98 %, respectively. The pooled analysis included 429 patients with a median follow-up of 26.1 months. Complications were predominantly minor and transient. Major complications included necrosis, hemorrhage, cranial nerve palsy, and death. Advanced surgical techniques and pre-treatment measures, such as internal carotid artery embolization, improved resection outcomes and reduced complication rates.
CONCLUSION: Transnasal endoscopic nasopharyngectomy emerges as a viable salvage option for advanced rNPC, offering favorable survival outcomes and manageable complication profiles. Future research should focus on refining surgical techniques and improving patient selection criteria to further enhance treatment efficacy.
The present invention discloses a Chinese medicinal powder capsule for eliminating arthralgia and a preparation method thereof. The formula of the present invention is prepared from twenty-one traditional Chinese medicines which have the functions of supplementing the liver and kidney, strengthening the tendons and muscles, nourishing blood, benefiting essence, expelling wind and dampness, activating blood circulation, supplementing qi, etc. The preparation method is divided into eight steps, and the traditional Chinese medicines are classified, processed and combined according to medical properties. The preparation method adopts the technology of fermentation which makes medicines fully absorbed by human bodies and rapidly exerts medicinal effect. The present invention is easy to take orally. The present invention is mainly used for controlling diseases of lumbocrural pain, sciatica, hyperostosis, etc. which happen to people in middle and old age, and is a Chinese patent medicine with high therapeutic effect, so the present invention has no side effect on human bodies.
Oral transmucosal fentanyl citrate is supplied in six dosage strengths. Each unit is individually wrapped in a child-resistant, protective blister package. These blister packages are packed 30 per shelf carton for use when patients have been titrated to the appropriate dose.

Each dosage unit has a white to off-white color. Each individual solid drug matrix is marked with “FENTANYL” and the strength of the unit (“200 MCG”, “400 MCG”, “600 MCG”, “800 MCG”, “1200 MCG”, or “1600 MCG”). The dosage strength is also marked on the handle tag, the blister package and the carton. See blister package and carton for product information.

Note: Colors are a secondary aid in product identification. Please be sure to confirm the printed dosage before dispensing.

Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° and 30°C (59° to 86°F) until ready to use [see USP Controlled Room Temperature]. Protect oral transmucosal fentanyl citrate from freezing and moisture. Do not use if the blister package has been opened.

Store oral transmucosal fentanyl citrate securely and dispose of properly [see Patient Counseling Information (17)].
PURPOSE:To form an oral intake composition useful as a healthy food for preventing hypertension and alleviating hypertensive tendency, by using inhibitory peptide of angiotensin converting enzyme derived from casein and egg yolk. CONSTITUTION:An oral intake composition containing a peptide inhibiting angiotensin converting enzyme(ACE for short) obtained by decomposing casein with protease and egg yolk. The peptide inhibiting ACE is usually isolated in the form of powder, blended with egg yolk and used as it is or preferably as a composition in any shape or configuration together with a proper nontoxic carrier for oral administration. Egg yolk of egg of chicken, quail, ostrich, etc., sold in the market can be used as the egg yolk. Total content of the inhibitory peptide of ACE and egg yolk is generally about 1-100wt%. and the ratio of the above-mentioned peptide and the egg yolk is generally about 1:10-3:1.
PURPOSE:To obtain an Al(OH)3.gel consisting of a specified compd. and useful in a field of application wherein said gel is used as an excellent antacid for acid in stomach, an acid adsorbing agent and a cation exchanger. CONSTITUTION:A soluble Al compd. (e.g. AlCl3) consisting of water-soluble and/or lower alcohol soluble salt, and a soluble compd. of a source for supplying carbonic ion (e.g. Na2CO3) are brought into reaction at pH6-9.5 at 20-50 deg.C so that molar ratio of CO2/Al in the Al(OH)3.gel obtained by the reaction become >=0.1. Then, the Al(OH)3.gel contg. <=2wt.% alkali metal and expressed in inequality I [wherein, M is alkali metal such as Na, K; x1-3 is the relation expressed in inequalities II-VII, respectively; (y) is positive number in the formula VIII, (m) is positive number in inequality IX] is formed by ion- exchanging the alkali metal contained in the obtained compd. with Ca, or Ca and Mg. The tablet of antacid, etc., is prepared by mixing said Al(OH)3.gel with a desired ecipient, etc., if necessary, and then is utilized for adjusting acidity for acid in stomach by dosing at the rate of 2-5g/day.
Long COVID was reported as a multi-systemic condition after the infection of SARS-CoV-2, and more than 65 million people are suffering from this disease. It has been noted that around 10% of severe SARS-CoV-2 infected individuals are suffering from the enduring effects of long COVID. The symptoms of long COVID have also been noted in several mild or asymptomatic SARS-CoV-2 infected individuals. While limited reports on clinical trials investigating new therapeutics for long COVID exist, there is an abundance of scattered information available regarding these trials. This review explores the extensive literature search, and complete clinical trial database search to map the current status of long COVID clinical trials worldwide. The study listed about 110 long COVID clinical trials. In addition to conducting extensive long COVID clinical trials, we have comprehensively presented an overview of the condition, its symptoms, notable manifestations, associated clinical trials, the unique challenges it poses, and our recommendations for addressing long COVID.
The present invention discloses one kind of osmotic pump controlled release tablet of venlafaxine hydrochloride. The tablet consists of medicine core of venlafaxine hydrochloride and semipermeable film coating with small holes. The medicine core consists of venlafaxine hydrochloride in 75 weight portions, stuffing in 30-250 weight portions, osmotic pressure promoter in 1-50 weight portions, adhesive in 1-20 weight portions and lubricant in 0.1-20 weight portions. The semipermeable film coating consists of semipermeable film coating material in 5-15 weight portions and plasticizer in 1 weight portion. The tablet has excellent release controlling effect, high safety and good patient dependence. The present invention also discloses the preparation process of the osmotic pump controlled release tablet of venlafaxine hydrochloride.
This group of participants will serve as control group and receive Reiki treatment in addition to routine clinical care. Reiki will be provided 40 mins/day, 2 days/week for 6 weeks (total of 12 sessions).