anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Total hip arthroplasty (THA) has become the first-choice treatment for elderly patients with end-stage hip disease. The high amount of hidden blood loss (HBL) in overweight and obese patients after THA not only affects rapid recovery, but also results in a greater economic burden. We aimed to identify risk factors that contribute to elevated HBL in overweight and obese patients after THA by retrospective analysis, and establish a nomogram prediction model for massive HBL in overweight and obese patients after THA.
METHODS: A total of 505 overweight and obese patients treated with THA were included and randomly divided into modeling and validation sets according to a 7:3 ratio. The demographic and relevant clinical data of the patients were collected. The independent risk factors affecting HBL after THA in overweight and obese patients were obtained by Pearson, independent sample T-test, and multiple linear regression analyses. R software was used to establish a nomogram prediction model for postoperative HBL, as well as a receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA).
RESULTS: HBL was 911±438 mL, accounting for 79.5±13.1% of the total perioperative blood loss (1104±468 mL). A multiple linear regression analysis showed that HBL was associated with necrosis of the femoral head, absence of hypertension, longer operative time, higher preoperative erythrocytes, and higher preoperative D-dimer levels. The areas under the ROC curve (AUC) for the modeling and validation sets were 0.751 and 0.736, respectively, while the slope of the calibration curve was close to 1. The DCA curve demonstrated a better net benefit at a risk of HBL ≥1000 ml in both the training and validation groups.
CONCLUSION: HBL was an important component of total blood loss (TBL) after THA in overweight and obese patients. Necrosis of the femoral head, absence of hypertension, longer operative time, higher preoperative erythrocytes, and higher preoperative D-dimer levels were independent risk factors for postoperative HBL in these patients. The predictive model constructed based these data had better discriminatory power and accuracy, and could result in better net benefit for patients.
PROBLEM TO BE SOLVED: To provide a medicament delivery device with instructions that can be easily understood by an untrained user in any type of situation.SOLUTION: An apparatus 4002 includes a housing 4110, a medicament container and an actuator. The apparatus includes a label 4910 configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia 4916. The label further includes an electronic circuit system configured to output an electronic signal.
PROBLEM TO BE SOLVED: To provide an improved T cell vaccine and methods of making the vaccine.SOLUTION: A vaccine may be made by stimulating all epitopes of an antigenic polypeptide that may be capable of stimulating autoreactive T cells with T cells. A method of identifying an epitope within a polypeptide antigen for an autoreactive T cell is provided. A sample comprising T cells isolated from a host may be provided. One or more different peptides may be added to a plurality of portions of the sample. The sequences of the peptides may collectively comprise a portion of the sequence of the polypeptide antigen. A portion of the sample comprising activated autoreactive T cells may be identified. A peptide that activates the autoreactive T cells may comprise the epitope.SELECTED DRAWING: None
A single-center prospective interventional single-arm clinical trial. All patients will undergo whole-body 68Ga-FAPI-46 PET scan within two weeks before or after 18F-FDG-PET. Injected activity of 68Ga-FAPI-46 is limited to 100-250 MBq per examination.
This research will be a prospective, cohort study to determine if mothers of infants/newborns are more willing to complete CPR training using a 22-minute instructional DVD and infant manikin versus traditional four hour didactic instruction. Participants of the study will include mothers ages eighteen years and older, being treated as inpatients on the Mother Baby Unit (MBU) at the Cedar Crest (CC) site. Participants must have given birth within the last twenty-four hours, to a baby receiving care in the MBU nursery or the Neonatal Intensive Care Unit (NICU). Consent will be obtained from mother to participate. The control group will consist of those mothers who are currently certified in CPR (i.e., have taken the traditional CPR class, or have been recertified in CPR by classroom instruction, within the past two years). It is expected that this group will not have many participants because it is predicted that not many mothers will be certified in infant CPR prior to giving birth. After being consented, mothers will be surveyed, and tested on their CPR knowledge and proficiency before hospital discharge. The experimental group will consist of those participants who are not currently certified in CPR (i.e., have had traditional CPR training over two years ago which has lapsed, or who have never been certified in CPR). These participants will be consented, surveyed, asked to watch a 22-minute instructional DVD with an infant manikin, and then tested on CPR knowledge and proficiency before hospital discharge. Surveys will include questions pertaining to participant demographics, previous CPR learning experiences, reasons for obtaining and approximate cost of previous CPR instruction, and rating their instructional experiences (e.g., ease, quality of instruction, convenience, and effectiveness). Research staff will become CPR Instructors; and to ensure the inter-rater reliability each member of the staff will independently score CPR knowledge and performance in a series of mock CPR testing scenarios. During the study, research staff will be blinded to the group that the participants are enrolled in. Therefore, if one research staff member enrolls the participant, another blinded research staff member will assess the participants CPR proficiency in order to eliminate any instructor bias. Follow-up phone calls will be conducted 6 months post enrollment to measure the multiplier effect and to inquire about the incidence of having to use CPR skills in a real-life situation. Scores on participant's written and practical tests, responses to survey questions and follow up phone calls will be compared between groups.
This condition includes 22 UCAN sessions and 22 CBT sessions, totaling 44 psychotherapy sessions. UCAN is a manualized, 22-session Cognitive Behavioral Couple Therapy (CBCT) intervention that engages the couple to target the core psychopathology of AN and address the uniquely challenging stress that AN places on intimate relationships. The CBT proposed for this study is a 22 session adaptation of the manualized intervention that has been employed successfully as an outpatient post-hospitalization therapy and in an National Institute of Mental Health multisite study of fluoxetine with elements from the CBT manual used in McIntosh et al (PubMed 15800147).
For the Telemedicine Group, the study initiates with a video call from the physician on day one via FaceTime or WhatsApp. During these calls, patients will receive guidance and complete Quick-DASH questionnaire and numeric-VAS scale. On the same day, they will also receive an exercise video and an exercise diary via WhatsApp. Follow-up video calls on the 7th day will serve as reminders and allow patients to ask questions. The final video call, scheduled for the 15th day, will involve completing the same questionnaire and scale. After this last remote interaction, patients will send photos of their completed exercise logs to the physician via WhatsApp for adherence tracking.
Depending on the patient's ability to swallow pills, patients in the experimental group will receive 200mg of Ubiquinol in either a pill or a liquid. The liquid form of the study med will be mixed with 50 milliliters of Ensure (a dietary supplement) to ensure blinding. This will be given every 12 hours for 7 days or until hospital discharge.
1,170,741. Pelleting fusible materials. ELLIOTT ASSOCIATED DEVELOPMENTS Ltd. 14 Nov., 1966 [12 Aug., 1965], No. 34605/65. Heading B5A. Resins, e.g. cumarone, waxes, pitch, low temperature metal alloys or sulphur, are pelletized or pastillated by the discharge of molten drops thereof from a plurality of groups of spaced drop forming heads 15, each comprising a nozzle with a reciprocating plunger therein, into an elongated tank 12 of water or other cooling liquid under the liquid surface, whereof operates a slow moving stainless steel conveyer band or screw conveyer on to which the solidified drops collect and are conveyed and discharged into a sump 18 whence they are delivered, through a valve 9, to a rotary screen 20 by a pump 21 provided with a rubber or rubber lined screw impeller. Pellets that do not sink are collected against baffles 22 at the discharge end of the tank 12 and may be treated with an additive to make them sink. The tank water preferably contains an anti-stick additive e.g. a dimethyl silicone fluid, so that pellets may pile up upon one another on the conveyer without sticking. The cooling water temperature is maintained constant by continuously introducing cool water near the bottom of the tank 12 and removing overflow hotter water from the top thereof. The feed temperature to the nozzles is maintained close to the feed melting point so that the formation of " tails " is avoided on the drops, or the feed, e.g. sulphur, may be supercooled.
Introduction Magenta™ is a software image analysis tool developed by Future Fertility that allows personalized reproductive prediction for each oocyte (egg cell) analyzed. It is a cloud-based software that was developed to assess the probability of an oocyte to fertilize and develop into a blastocyst (ball of rapidly dividing cells that will become an embryo). It is a non-invasive image analysis tool that uses artificial intelligence (AI) to predict outcomes based on a single 2-D image of a mature oocyte (denuded oocyte) prior to freezing or sperm injection (ICSI). Magenta™ was designed and built specifically to analyze oocytes in the IVF lab. It was created based on more than 20,000 images of oocytes and their known reproductive outcomes. It is an image analysis neural network that can identify important signals beyond the limited morphological features detected by embryologists, like facial recognition systems in use today. Without the development of this AI tool, there are no standard assessments for oocyte quality within the IVF process. The use of Magenta™ in this study is investigational.

In standard IVF laboratories, oocytes can undergo their developmental period alone (single culture) or be grouped with other oocytes during this time (group culture). Research has shown that group culture has some developmental advantages over single culture.

What is this study for? At the moment, there is no standard method to sort oocytes into groups for their developmental period. Currently, oocytes are sorted in a random manner. We hope that Magenta™ analysis will provide information at this early stage of development and inform a better way to sort oocytes into groups (from lowest to highest quality). The objective of this research study is to compare sorting the oocytes randomly to utilizing the MagentaTM tool for oocyte assessment to determine which oocytes should be grouped together. Study participants will be randomly assigned to the control (random sorting) or the study (Magenta™ analysis) groups at the time of oocyte retrieval. You have an equal chance of being assigned to either group. We intend to enroll 450 subjects.
Bacterial infections are associated with high mortality in intensive care patients. Antibiotic therapy is the only causal opportunity to treat those infections. Pharmacokinetic and -dynamic changes in critically ill patients lead to unpredictable plasma concentrations of the applied drugs. Research results of the last years with many quantified plasma concentrations in subtherapeutic levels yield to the recommendation of the Paul-Ehrlich-Society for an routines therapeutic drug monitoring of antibiotics in intensive care patients. These was implemented in January 2018 at Clinic for Anesthesiology at University Hospital, LMU Munich, Germany for all intensive care patients as a routines procedure. The introduced study is a prospective evaluation of the TDM-program with regard to improvement opportunity, influencing factors and parallels to other studies.
PURPOSE:To improve the applicability and preservability of a vegetable drug component, by putting a proper amount of a vegetable extract in an aerosol container, and sealing N2, CO2, N2O, fleon, L.P.G, etc. in the can under pressure. CONSTITUTION:A proper amount of a vegetable extract is put into an aerosol container, and at least one kind of gas selected from nitrogen gas (N2), carbon dioxide gas (CO2), laughing gas (N2O), fluorine-containing gas (fleon), and liquefied petroleum gas (L.P.G) is sealed in the container under pressure. The extract of the drug component of various vegetables (e.g. herbs such as Houttuynia cordata, mushroom such as polypore, etc.) is made to be usable easily and preservable for a long period. The amount of the extract in the container is 60- 90%. The pressure in the container is preferably 1.5-8kg/cm<2> at 38 deg.C. The preservability of the extracted liquid can be improved by adding a specific amount of an alcohol.
BACKGROUND: Acute kidney injury (AKI) is characterized by rapid renal decline. Periodontitis, a chronic oral inflammatory disease, is increasingly associated with renal dysfunction. Although periodontitis is recognized as a contributor to kidney damage, the mechanisms linking it to AKI remain unclear.
METHODS: This study explored the effects of Porphyromonas gingivalis (P. gingivalis) W83-infected periodontitis on AKI in C57BL/6J mice, using ischemia-reperfusion injury 55 days post-infection. Gingipain inhibitors, KYT-1 and KYT-36, were applied. Detection of P. gingivalis was performed using quantitative real-time polymerase chain reaction (qRT-PCR) and PCR, while transcriptome sequencing, qRT-PCR, immunohistochemistry, and immunofluorescence staining assessed renal damage. In vitro, HK-2 cells were exposed to P. gingivalis at a multiplicity of infection of 10 for 48 h, with inhibition by gingipain or oncostatin M (OSM). Disruption of tight junctions (TJs) was quantified using qRT-PCR, transepithelial electrical resistance, and cell counting kit-8 assays.
RESULTS: Periodontitis worsened AKI, linked to P. gingivalis infection and renal TJ disruption in the kidney. P. gingivalis infection activated OSM expression, which correlated positively with gingipain. Significantly, OSM and gingipain might collaboratively contribute to the damage of renal TJs, with the reduced expression of TJ proteins. Suppressing gingipain activity presented itself as a protective strategy against the destruction of TJs and the attendant worsening of AKI due to periodontitis.
CONCLUSIONS: Our study enhances the understanding of the interplay between periodontitis and AKI, highlighting the harmful impact of P. gingivalis in AKI.
This is a multi-center, randomized, non-inferiority phase 3 study conducted to determine an appropriate anti-emetic regimen for patients receiving melphalan for an autologous stem cell transplant (SCT). Candidates for this trial will include patients aged 18-80 years with hematologic malignancies receiving high dose melphalan as part of a conditioning regimen for an autologous stem cell transplant. Patients will be enrolled in 3 arms. Patients in Arm A will receive an aprepitant containing anti-emetic regimen. Patients in Arm B will receive an olanzapine containing anti-emetic regimen. Patients in Arm C will receive an aprepitant plus olanzapine containing anti-emetic regimen. Patients must be able to tolerate oral medications.

Patients will be carefully monitored for rates of emesis, nausea, and mucositis. Any adverse events will be recorded. Impact on quality of life will also be assessed. A total of 184 patients will be accrued to each arm. It is anticipated that the accrual period will last approximately 2-3 years. The primary endpoint of this study is a complete response, defined as no emesis and no rescue therapy within 120 hours of melphalan administration.
AIMS: The role of depression in subsequent infertility, miscarriage and stillbirth remains unclear. This study aimed to examine the association of a history of depression with these adverse outcomes using a longitudinal cohort study of women across their reproductive life span.
METHODS: This study used data from participants in the Australian Longitudinal Study on Women's Health who were born in 1973-1978. Participants (N = 8707) were followed up every 3 years from 2000 (aged 22-27) to 2018 (aged 40-45). Information on a diagnosis of depression was collected from each survey, and antidepressant medication use was identified through pharmaceutical prescription data. Histories of infertility, miscarriage, and stillbirth were self-reported at each survey. Time-lagged log-binomial models with generalized estimating equations were used to assess the association of a history of depression up to and including in a given survey with the risk of fertility issues in the next survey.
RESULTS: Women with a history of depression (excluding postnatal depression) were at higher risk of infertility [risk ratio (RR) = 1.34, 95% confidence interval (CI): 1.21-1.48], miscarriage (RR = 1.22, 95%CI: 1.10-1.34) and recurrent miscarriages (≥2; RR = 1.39, 95%CI: 1.17-1.64), compared to women without a history of depression. There were too few stillbirths to provide clear evidence of an association. Antidepressant medication use did not affect the observed associations. Estimated RRs of depression with infertility and miscarriage increased with age.
CONCLUSIONS: A history of depression was associated with higher risk of subsequent infertility, miscarriage and recurrent miscarriages.
OBJECTIVES: To investigate the role and mechanism of epithelial-mesenchymal transition (EMT) in a rat model of bronchopulmonary dysplasia (BPD).
METHODS: The experiment consisted of two parts. (1) Forty-eight preterm rats were randomly divided into a normoxia group and a hyperoxia group, with 24 rats in each group. The hyperoxia group was exposed to 85% oxygen to establish a BPD model, while the normoxia group was kept in room air at normal pressure. Lung tissue samples were collected on days 1, 4, 7, and 14 of the experiment. (2) Rat type II alveolar epithelial cells (RLE-6TN) were randomly divided into a normoxia group (cultured in air) and a hyperoxia group (cultured in 95% oxygen), and cell samples were collected 12, 24, and 48 hours after hyperoxia exposure. Hematoxylin-eosin staining was used to observe alveolarization in preterm rat lungs, and immunofluorescence was used to detect the co-localization of surfactant protein C (SPC) and α-smooth muscle actin (α-SMA) in preterm rat lung tissue and RLE-6TN cells. Quantitative real-time polymerase chain reaction and protein immunoblotting were used to detect the expression levels of EMT-related mRNA and proteins in preterm rat lung tissue and RLE-6TN cells.
RESULTS: (1) Compared with the normoxia group, the hyperoxia group showed blocked alveolarization and simplified alveolar structure after 7 days of hyperoxia exposure. Co-localization of SPC and α-SMA was observed in lung tissue, with decreased SPC expression and increased α-SMA expression in the hyperoxia group at 7 and 14 days of hyperoxia exposure compared to the normoxia group. In the hyperoxia group, the mRNA and protein levels of TGF-β1, α-SMA, and N-cadherin were increased, while the mRNA and protein levels of SPC and E-cadherin were decreased at 7 and 14 days of hyperoxia exposure compared to the normoxia group (P<0.05). (2) SPC and α-SMA was observed in RLE-6TN cells, with decreased SPC expression and increased α-SMA expression in the hyperoxia group at 24 and 48 hours of hyperoxia exposure compared to the normoxia group. Compared to the normoxia group, the mRNA and protein levels of SPC and E-cadherin in the hyperoxia group were decreased, while the mRNA and protein levels of TGF-β1, α-SMA, and E-cadherin in the hyperoxia group increased at 48 hours of hyperoxia exposure (P<0.05).
CONCLUSIONS: EMT disrupts the tight connections between alveolar epithelial cells in a preterm rat model of BPD, leading to simplified alveolar structure and abnormal development, and is involved in the development of BPD. Citation:Chinese Journal of Contemporary Pediatrics, 2024, 26(7): 765-773.
The object of this invention is to provide a medical composition for oral administration or intravenous administration which comprises as an effective ingredient a pulverized product and/or extract obtained from Humulus lupulus and/or Angelica keiskei koidz or Xanthohmol and/or a pharmacologically acceptable salt thereof for a disease requiring enhancement of nerve growth factor production. This medical composition is also a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor production like dementia or nerve barrier and so on. This invention also provides one kind of food, beverage or feed comprising an effective ingredient mentioned above which can enhance production of nerve growth factor. The food or beverage as a daily diet can improve symptoms of a disease requiring enhancement of nerve growth factor production. The feed is good at maintaining body normality by enhancing production of nerve growth factor. Furthermore, the medical composition of this invention mentioned above is also good for improving or ameliorating learning and memorizing ability of life individual.
The invention relates to a traditional Chinese medicine composition for treating cerebral thrombosis sequelae. The traditional Chinese medicine composition is prepared from the following twelve traditional Chinese medicines: erodium stephanianum willd, Chinese polyphaga, mulberry twig, tiger-bones, fleece-flower roots, silkworm larva, agilawood, gastrodia elata, ginsengs, pseudo-ginsengs, eucommia ulmoides and radix angelicae pubescentis. The traditional Chinese medicine composition provided by the invention has the functions of relieving wind and dredging collaterals, regulating qi-flowing for eliminating phlegm, soothing tendons and relieving pains, tranquilizing and allaying excitement, nourishing yin and blood, eliminating phlegm and inducing resuscitation, dispelling wind and removing evil and the like, improves blood circulation and removes blood stasis, and fundamentally removes blood stagnation. Furthermore, the medicines can be directly acted on blood vessels and viscera to recover the resilience of the blood vessels and the components of the blood, so that the blood system recovers the self-adjusting function. Through comprehensive treatment, symptoms such as hemiplegia, language barrier, facial paralysis, hemianopsia and aphasia caused by cerebral thrombosis sequelae can be thoroughly relieved. The traditional Chinese medicine composition improves microcirculation, adjusts endocrine dysfunction and finally realizes the purpose of effectively treating cerebral thrombosis sequelae.