anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Asthma is the most common chronic disease in children. Although asthma often occurs in childhood, it can occur at any age. The incidence and prevalence of asthma is higher in children. On average, 5-10% of the world's population has an individual diagnosed with asthma, and one-third of these individuals are under the age of 18. In the United States of America (USA), approximately 6 million children between the ages of 0-17 are diagnosed with asthma. It has been reported that adolescents are at high risk for poor asthma outcomes, and death rates from asthma are twice as high in the 11-17 age group than in the 0-10 age group.

Peer relationships and peer support are of particular importance for children with chronic illnesses. Adolescents diagnosed with asthma value support from their peers. Adolescents tend to seek guidance from people with similar characteristics, and the opinions of individuals with similar characteristics are more valuable than those of individuals who do not have similar characteristics. Being with an adolescent diagnosed with asthma can improve the adolescent's sense of support and sense of normalcy. It is crucial to create an environment where adolescents diagnosed with asthma can interact with other adolescents diagnosed with asthma, thereby facilitating the formation of a support network.The research was planned in a randomized controlled trial to evaluate the effect of technology-based education provided by peers and adults to children diagnosed with asthma in the 12-18 age group. The study group of the study will consist of 45 adolescents (intervention group 1 \[n=15\], intervention group 2 \[n=15\], and control group \[n=15\]). The technology-based program will be applied to adolescents for 4-6 weeks through modules on the website. At the end of the study, it will apply website modules to the adolescents in the control group. The research is based on the Bandura's Self-Efficacy Theory.
Using conventional surgical procedures, higher postoperative near undercorrection and/or distant overcorrection rates were observed in CI-IXT. To achieve better outcome, S-BLR was introduced. Previous studies showed its efficacy in reducing near exodeviation, distant exodeviation, and NDD. So far, only limited studies have directly evaluated the surgical outcomes between S-BLR and C-BLR. The pilot study done by Snir et al included 12 patients with S-BLR and 6 patients with C-BLR and the success rates of S-BLR vs C-BLR were 92% vs 0 at one-year follow-up. The retrospective study done by Song et al included 17 patients undergoing S-BLR and 14 patients undergoing C-BLR. With stricter successful criteria, the success rates of S-BLR vs C-BLR were 35% vs 7% at six-month follow-up. A large randomized trial is needed to compare the surgical successful rate and suboptimal surgical outcomes of S-BLR with C-BLR in children with CI-IXT.

The proposed trial will be conducted in 6 different study sites working in the field of pediatric ophthalmology and strabismus.Each site will have one certified surgeon to do all surgeries. Under general anesthesia, the LR recession is performed using an inferior-temporal fornix incision. For S-BLR, the lower horn of the LR is recessed based on near exodeviation and the upper horn is recessed based on distant exodeviation. For C-BLR, the LR is recessed based on distant exodeviation. Surgical dose is according to the largest preoperative exodeviation at distance (6 meters) or near (1/3 meter) by the prism and alternate cover test(PACT). The extent of the recession is based on Parks' surgical dosage schedule.
PURPOSE: A cosmetic composition containing a Viscum album var. extract exhibiting a cell membrane binding inhibiting effect of MSH for protecting melanin formation, human tyrosinase activity inhibiting effect, tyrosinase-synthesis inhibiting effect, melanin-production inhibiting effect and cell death inhibiting effect, and inflammation-inducing enzyme activity inhibiting effect is provided which is used as a cosmetic having a skin whitening effect and skin irritation reducing effect. CONSTITUTION: Viscum album var. coloratum(KOM.) OHWI. is extracted in one or more solvents selected from purified water, lower alcohol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloro methane and hexane. The extract is filtrated then concentrated or freeze-dried. A skin whitening cosmetic contains 0.01 to 30% by weight of the Viscum album var. extract, based on the total weight of the composition.
PURPOSE:To provide a product having a high medical effect, high nutritive value and characteristic flavor, by adding specific amounts of the dry powder of field horsetail and chlorella and processing the mixture into noodles. CONSTITUTION:Preferably the new sprouts of field horsetail are dried by an electrothermally drying process, a freeze-drying process, etc., and subsequently ground into an ultrafine powder. The powder is homogeneously mixed with a grain flour such as wheat flour and subsequently kneaded with a salt water in which a prescribed amount of chlorella powder is dispersed. The kneaded product is shaped into a plate-like product with rollers and subsequently aged. The dry powder of the field horsetail and the chlorella are compounded in amounts of 1-5 pts.wt. and 0.1-2.0 pts.wt., respectively, based on 100 pts.wt. of the grain flour. After suitably aged, the plate product is further rolled into a sheet-like product and cut into string-like noodles. The noodles may be dried into dry noodles, if desired. As the raw material grain flour, a mixture of buckwheat flour and wheat flour as well as the wheat flour as the main component can be employed.
PURPOSE OF REVIEW: Recent literature suggests a potential causal link between metabolic bariatric surgery (MBS) and an increased risk of eating disorders. However, the available literature offers unclear results regarding the definition of eating problems among MBS patients, their potential impact on weight outcomes, and the efficacy of adjunctive treatment.
RECENT FINDINGS: Although eating disorders may be rare phenomena after surgery, disordered eating behaviors are more common and tend to be more consistently associated with suboptimal weight loss. There also appear to be clear problems when using Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) criteria to assess eating disorders among MBS patients, particularly for restrictive eating, binge-eating episodes, and the core psychopathology of eating disorders. Finally, preoperative interventions appear to offer effects limited to the presurgery period, and the evidence for the efficacy of postoperative interventions remains limited. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) offer promising benefits for weight loss and the treatment of binge-eating problems, but their potential risks must be carefully managed.
SUMMARY: Recognizing the diverse presentations of these problems among individuals undergoing MBS is crucial. Clinical attention should focus on intensive specialized care during the postoperative period for those who develop eating-related problems.
FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention proposes suppository containing the following components, g: anaesthesin 0.08-0.12; menthol 0.003-0.005; dermatol 0.03-0.05, and zinc oxide 0.016-0.024, and polyethylene oxide-1500 and polyethylene oxide-400 as a base at ratio 19:1. Anaesthesin powder is mixed with polyethylene oxide-1500 at ratio 1:23 at 50-55 C for 20-30 min. The obtained mass is cooled to 45-52 C, menthol is added and stirred mass for 10-20 min. Simultaneously dermatol and zinc oxide concentrates were prepared by their grinding with polyethylene oxide-400 at ratio 0.5: 1 for 1.5-2 h. The obtained concentrates were added to early prepared mass, stirred for 1 h at 45-52 C and mass is poured in cellular counter package made of film at 10-15 C for 40 min. New medicinal composition shows analgetic, antiseptic and disinfecting effect in combination with good absorption of active components. EFFECT: enhanced effectiveness of suppository, improved method of making. 4 cl, 4 tbl
PURPOSE:To obtain a drug for external use, containing kojic acid, having increased water solubility and included in maltosylcyclodextrin and having great melanization inhibitory effects. CONSTITUTION:The titled drug for external use containing kojic acid included in maltosylcyclodextrin. The above-mentioned included kojic acid is obtained by dispersing maltosylcyclodextrin in water, stirring the dispersion while slowly adding the kojic acid thereto and completely dissolving both. Since water solubility of the kojic acid is increased by the treatment, even 6% kojic acid can be blended in the drug for external use though the amount of the kojic acid which can be blended therein has hitherto been only 2.7%. Thereby a pharmaceutical having a wide range of change in content depending on the dosage form or symptoms is obtained. The amount of the blended maltosylcyclodextrin is preferably 1-5pts.wt. based on 1pt.wt. kojic acid.
1408437 Vaccines C-VET Ltd 16 Oct 1973 [16 Oct 1972] 47627/72 Heading A5B A vaccine comprises an antigenic material and is in the form of a multiple oil-water emulsion having a continuous aqueous phase and a primary oil phase in which a secondary aqueous phase is disposed, the concentration of oil in the vaccine being less than 20% by volume, and the percentage of antigenic material in the secondary aqueous phase being from 1 to 20%, the remainder of the antigenic material being present in the continuous aqueous phase. The vaccine may be prepared by subjecting to emulsifying conditions a waterin-oil emulsion containing 1 to 20% of the antigenic material in its aqueous phase, an emulsifying agent and an aqueous medium containing the remainder of the antigenic material, to form a multiple oil-water-emulsion, the proportions of water-in-oil emulsion, emulsifying agent and aqueous medium being such that the concentration of oil in the vaccine is less than 20% by volume. The antigenic material is suitable for the immunisation of domestic animals or livestock. The vaccine may be injected or locally administered to the animal. A vaccine suitabel for immunising cats comprises an antigen derived from feline panleucopenia virus, feline rhinotracheitis virus or feline picornavirus. A vaccine suitable for immunising dogs comprises an antigen derived from canine parainfluenza (SV5-like) virus, or canine adeno (1 and 2) viruses. Cattle may be immunised with a vaccine which comprises a mixture of parainfluenza 3, reo, adeno, bovine diarrhoea and infectious bovine rhinotracheitis. The vaccine may be administered to cattle by more than one injection, the second injection being administered after 1 to 6 weeks.
Training is based on 5 circuits, with intervals of 1 minute (high intensity) by 2 minutes (low intensity), with a total training time of 15 minutes (plus 5 more minutes of warm-up and 5 of cool-down exercises). The high intervals will be performed with the following exercises: squat, reverse lunge \& knee-up, reverse jump and walkout pushup, while the low intervals were performed jogging. The heart rates of the study subjects will be calculated using the Astrand test and the progression criteria is going to be based on an increase in maximum heart rate of 85% to 95%. To monitor heart rate during training, a polar brand chest sensor, model H9, will be used.
INTRODUCTION: Body mass index (BMI) is inadequately recorded in US administrative claims databases. We aimed to validate the sensitivity and positive predictive value (PPV) of BMI-related diagnosis codes using an electronic medical records (EMR) claims-linked database. Additionally, we applied machine learning (ML) to identify features in US claims databases to predict obesity status.
RESEARCH DESIGN AND METHODS: This observational, retrospective analysis included 692 119 people ≥18 years of age, with ≥1 BMI reading in MarketScan Explorys Claims-EMR data (January 2013-December 2019). Claims-based obesity status was compared with EMR-based BMI (gold standard) to assess BMI-related diagnosis code sensitivity and PPV. Logistic regression (LR), penalized LR with L1 penalty (Least Absolute Shrinkage and Selection Operator), extreme gradient boosting (XGBoost) and random forest, with features drawn from insurance claims, were trained to predict obesity status (BMI≥30 kg/m2) from EMR as the gold standard. Model performance was compared using several metrics, including the area under the receiver operating characteristic curve. The best-performing model was applied to assess feature importance. Obesity risk scores were computed from the best model generated from the claims database and compared against the BMI recorded in the EMR.
RESULTS: The PPV of diagnosis codes from claims alone remained high over the study period (85.4-89.2%); sensitivity was low (16.8-44.8%). XGBoost performed the best at predicting obesity with the highest area under the curve (AUC; 79.4%) and the lowest Brier score. The number of obesity diagnoses and obesity diagnoses from inpatient settings were the most important predictors of obesity. XGBoost showed an AUC of 74.1% when trained without an obesity diagnosis.
CONCLUSIONS: Obesity prevalence is under-reported in claims databases. ML models, with or without explicit obesity, show promise in improving obesity prediction accuracy compared with obesity codes alone. Improved obesity status prediction may assist practitioners and payors to estimate the burden of obesity and investigate the potential unmet needs of current treatments.
Participants will receive 6 sessions of intermittent theta burst stimulation (iTBS) and the LoveYourBrain Yoga program. The LoveYourBrain Yoga program was specifically designed for people with TBI.
The present invention discloses a biological activity additive used in a shampoo and manufacturing and using methods. Leather whistle, polygonum multiflorum, neem leaves, rice bran, silk sericin, wheat bran and soybean meal are evenly mixed. The product is gained by heating, cooling, fermenting, alcohol extracting and concentrating the mixture and then mixing the mixture with Chinese spicebush oil. The additive is added to the matrix formula of the prior art; the biological activity shampoo is gained by producing with regular processing. The effectiveness of the hair cleaning product is effectively improved. The present invention adopts overall solid biotransformation technology to process various prescription medicines. The irritation of raw materials is reduced; the biological activity of the raw materials is kept; the biological activity is easier to be absorbed by the hair and the effectiveness of the activity extract is fully played. The Chinese spicebush oil is used as oily material, so the impact of chemical synthesis of oily material on hair is avoided. The dosage of the shampoo with activity additive is obviously reduced; but the effect is better than commercial selling products.
OBJECTIVES: This systematic review and meta-analysis evaluates and compares the effects of two treatments that ablate the posterior nasal nerves for rhinitis-related symptoms: cryotherapy and radiofrequency neurolysis.
METHODS: We reviewed studies retrieved from PubMed, SCOPUS, Embase, the Web of Science and the Cochrane database up to June 2023. Papers reporting quality-of-life and rhinitis-related symptom scores before and after cryotherapy, and sham-controlled studies, were analyzed.
RESULTS: In total, 738 patients enrolled in 10 studies were evaluated. Both cryotherapy and radiofrequency neurolysis significantly improved rhinitis-related symptoms including congestion, itching, rhinorrhea, and sneezing, and quality of life during 12 months of follow-up. Radiofrequency neurolysis was significantly more effective than cryotherapy in terms of reducing total nasal symptom scores at up to 12 months postoperatively. In terms of individual symptoms, itching, rhinorrhea, and congestion were significantly alleviated or tended to be reduced more by radiofrequency neurolysis than by cryotherapy. The improvements in the minimal clinically important difference in total nasal symptom scores (1.0 point) after 3 months of cryotherapy and radiofrequency therapy were 81.8 % and 92.7 %, respectively.
CONCLUSIONS: Cryotherapy and radiofrequency neurolysis both improved rhinitis-symptom and quality-of-life scores. Especially, radiofrequency neurolysis showed the better effectiveness for improving the nasal symptoms related to the rhinitis than cryotherapy.
The participant will place a towel under the plantar surface of the foot and, using both hands, pull the towel towards themselves until they feel a stretch in the calf muscle. Subsequently, they will be asked to maintain this position for 3 minutes. The stretching exercise will be performed in 3 sets per day.
### Controlled Substance

OPANA ER contains oxymorphone, an opioid with an abuse liability similar to morphine and other opioid agonists and is a Schedule II controlled substance. OPANA ER and other opioids used in analgesia, can be abused and are subject to criminal diversion (see WARNINGS: Misuse, Abuse and Diversion of Opioids).

Drug addiction is characterized by a preoccupation with the procurement, hoarding, and abuse of drugs for non-medicinal purposes. Drug addiction is treatable, utilizing a multi-disciplinary approach, but relapse is common.

"Drug seeking" behavior is very common to addicts and drug abusers. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing or referral, repeated claims of loss of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s). “Doctor shopping” (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. OPANA ER, like other opioids, may be diverted for non-medical use. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests is strongly advised.

Abuse of OPANA ER poses a risk of overdose and death. This risk is increased with concurrent abuse of OPANA ER with alcohol and other substances. In addition, parenteral drug abuse is commonly associated with transmission of infectious disease such as hepatitis and HIV.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.

Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (seePRECAUTIONS: Usage in Pregnancy and PRECAUTIONS: Labor and Delivery).
Hip dislocation is a common complication in patients who undergo reconstruction surgery after periacetabular tumor resection and most of these cases are anterior dislocations. Studies suggest that this type of dislocation may be closely related to the position and anteversion angle of the acetabular component. Therefore, properly reducing the anteversion angle of the acetabular cup during reconstruction might effectively prevent possible collisions between the cup and the femoral component, thereby reducing the potential risk of dislocation. Based on this theory, we aim to investigate whether patients who receive modified anteversion angle (( α-15°)±10°) of the acetabular cup have a lower risk of dislocation within one year after surgery, compared to patients who receive conventional anteversion angle ( α±10°) of the acetabular cup.

PS: α refers to the preoperative anteversion angle of the affected hip. α equals to the anteversion angle of the contralateral limb if it cannot be accurately measured on the affected size. A standard error within 10° is accepted.
In a medical health care network (10) for providing individualized health care programming to many patients, a method and apparatus for updating the programming is described. When a patient is new to the system, a health care professional takes a generic care plan template (26) and fills it in with the patient's specific health information. A care plan scheduler (36), using a completed template (26), assigns content for the patient to experience. When new content becomes available, the health care professional notes it on the template (26). The scheduler (36) then looks for all instances of the old content and replaces it with the new content in the most seamless way possible. A content replacement database (40) interprets old data in light of the new content so that the old data does not become misleading or obsolete.
Anemia has occurred in NSAID-treated patients. This may be due to occult or gross blood loss, fluid retention, or an incompletely described effect on erythropoiesis. If a patient treated with celecoxib has any signs or symptoms of anemia, monitor hemoglobin or hematocrit.

In controlled clinical trials the incidence of anemia was 0.6% with celecoxib and 0.4% with placebo. Patients on long-term treatment with celecoxib capsules should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia or blood loss. 

NSAIDs, including celecoxib, may increase the risk of bleeding events. Co-morbid conditions such as coagulation disorders or concomitant use of warfarin, other anticoagulants, antiplatelet drugs (e.g., aspirin), SSRIs and serotonin norepinephrine reuptake inhibitors (SNRIs) may increase this risk. Monitor these patients for signs of bleeding [see Drug Interactions (7)].
A real-time cloud imaging system includes at least a frontend device and a backend system. The frontend device generates an instruction message and a ROI (Region of Interest) message, and the backend system is coupled to the frontend device. The backend system has at least a raw image, wherein the raw image has a plurality of images of different resolutions. Each of the images and the raw image are composed of a plurality of tiles. The ROI message corresponds to a region of interest respectively within each of the images and the raw image. The backend system, according to the instruction message and the ROI message, selectively provides a grouping of the tiles within the region of interest of the raw image or one of the images to the frontend device.
PROBLEM TO BE SOLVED: To obtain the subject preparation which is useful for external use, has excellent inhibitory effects on skin aging phenomena such as the oxidation, inflammation and melamine generation of skin and scalp due to aging and oxidative stresses by exposure of UV light and the like, and can exhibit high safety by adding a specific plant extract as an active ingredient. SOLUTION: This skin preparation for external use contains at extract of Filipendula ulmaria (L.) Maxim as an active ingredient. The raw material for the extract is preferably one or more of the roots, seeds, petals, leaves and stems of the Filipendula ulmaria (L.) Maxim. The extract can be obtained by extracting the extraction raw material with 1-100 wt. times of water, an organic solvent or their mixture preferably at 30-60 deg.C. The extract is preferably added in an amount of 0.0001-10 wt.%. Thereby, the skin aging-preventing preparation which is used for external use and has an excellent anti-oxidizing effect, an active oxygen seed-scavenging effect, and the like, can be provided.