anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a compound preparation aspirin and caffeine tablet low in content of free salicylic acid and a preparation method thereof. The compound preparation aspirin and caffeine tablet comprises the following raw materials, by weight, 25-32 parts of aspirin, 2.7-3.9 parts of caffeine, 1.239-1.939 parts of pregelatinized starch, 5.125-6.125 parts of starch, 0.55-0.95 part of dextrin, 0.26-0.34 part of citric acid, 0.120-0.196 part of hydroxypropyl methyl cellulose, and 0.58-0.72 part of sodium carboxymethyl starch. 2% hydroxypropyl methyl cellulose solution and citric acid solution are prepared. The citric acid solution can be obtained as long as the citric acid is dissolved in purified water which is boiled and then cooled and is 1.8 times more than the citric acid in weight. After the aspirin, caffeine, the pregelatinized starch, the sodium carboxymethyl starch, the starch and the dextrin are mixed, the citric acid solution is added, the mixture is stirred, and then the 2% hydroxypropyl methyl cellulose solution is added. Soft materials are obtained after the mixture is stirred. The soft materials are made into wet particles. The wet particles are dried, and the content of water in the wet particles is controlled to be 0.7%-1.5%. Finally, mixing, tablet pressing and coating are conducted. The method is simple, and the content of free salicylic acid in obtained products is obviously reduced.
The invention discloses a near-infrared conjugated polymer, a preparation method thereof and application thereof in living body imaging and living body tumor treatment. The conjugated polymer is polymerized by a platinum complex and an alkyne monomer. The invention utilizes the coupling effect of Pt to improve the photo-thermal treatment effect, and adjusts the photo-physical property of the polymer through a conjugated system, thereby obtaining the conjugated polymer which has near infrared absorption performance and good photo-thermal imaging effect and can be used for treating the tumor of a living mouse. The conjugated polymer can be used in the technical fields of photodynamic therapy, photothermal therapy, biomarkers, detection and the like under the guidance of photothermal imaging. The preparation process is simple, the raw materials are cheap and rich, and the industrial production is convenient. The structural general formula of the near-infrared conjugated polymer is shown as follows.
Participants will apply a vehicle cream matched in texture, appearance, and odor to clacoterone to the affected area twice daily got a total of 12 weeks with assessment visits at weeks 0, 4, 8, and 12. At assessment visits participants will have medical photography of the diseased area, be administered a dermatology-specific quality of life questionnaire, and be assessed for any side effects.
BACKGROUND: Reoperation for post hepatectomy complications is associated with high rates of morbidity and mortality. We aim to describe the frequency, indications, and risk factors for reoperation after liver resection in a single centre.
METHODS: Perioperative data of 464 patients, who underwent elective hepatectomy from 2001 to 2020 at The Queen Elizabeth Hospital in South Australia, were retrospectively analysed. The frequency and indications for reoperation for post hepatectomy complications were recorded. Binary logistic regression analysis was performed to determine variables associated with reoperation.
RESULTS: A total of seven patients (1.5%) underwent reoperation post hepatectomy. The most common indications for reoperation were intra-abdominal abscess, post-operative haemorrhage, bile leak, and ischaemic bowel. Three out of the seven patients died. Patients were more likely to require reoperation if an additional major non-hepatic procedure was performed.
CONCLUSION: Reoperation post hepatectomy is associated with morbidity and mortality and is more likely to occur in patients who have undergone a non-hepatic procedure at the same time as the primary hepatic resection. Surgeons should ensure these patients are appropriately monitored and be selective about performing complex, multiple procedures. When possible, procedures should be staged.
Standard of care: routine clinic appointments until they deliver, fetal heart rate and contraction monitoring during their 41st week if not delivered. Also if they have not gone into labor the subjects will be scheduled for an induction by 42 weeks.
The present invention relates to targeted delivery systems for delivering therapeutic agents to tumor. The invention further relates to methods of delivering a therapeutic agent to a tumor for the prevention and treatment of cancer by killing tumor cells and tumor associated endothelial cells. In particular, the present invention provides a tumor-targeted drug delivery system comprising a NGR-containing molecule linked to a delivery vehicle encapsulating a therapeutic agent, preferably a drug, such as a cytotoxic agent or a chemotherapeutic agent. Specifically, the delivery systems of the present invention are capable of delivering an increased amount of therapeutic agent to a tumor as compared to other delivery systems. In particular, the delivery systems of the present invention are capable of accumulating a higher amount of therapeutic agent in a tumor, or in the vicinity of a tumor cell or tumor-supporting cell, resulting in exposure of the tumor cell and tumor associated endothelial cell to therapeutic levels of the agent for a longer period of time as compared to other delivery systems. The present invention also describes pharmaceutical compositions comprising the delivery systems of the present invention. The present invention further relates to a tumor treatment comprising an increased amount of therapeutic agent delivered by the system of the present invention as compared to other delivery systems. The delivery systems and pharmaceutical compositions can be administered to a subject, preferably a human, alone or in combination, sequentially or simultaneously, with other prophylactic or therapeutic agents and/or anti-cancer treatments.
Hypothermia has been confirmed and widely applied in the treatment of coma patients after resuscitation from cardiac arrest, but its effect on the prognosis of patients with AIS is still controversial. Previous basic research has confirmed that hypothermia can significantly reduce the infarct volume and improve the survival rate and behavioral defects of mice by protecting ischemic brain tissue and improving reperfusion injury through a variety of ways. Therefore, we hypothesized that hypothermia can improve the prognosis of patients with AIS after reperfusion by improving reperfusion injury. This is a phase II clinical trial to to verify the efficacy and safety of endovascular hypothermia in these patients,This study enrolled patients with massive cerebral infarction after endovascular treatment recanalization, patients are divided into study group and control group. The study group received endovascular hypothermia for 12 hours following endovascular treatment and recanalization, and the control group received only usual medical treatment following endovascular treatment and recanalization. We will preliminarily explore the mechanism of endovascular hypothermia in successful reperfusion of large vessel occlusion AIS, and to provide reference for the design of future clinical trials.
Patients in acupuncture group will receive traditional Chinese acupuncture using Press Tack Needle (PYONEX 0.20 x l.5mm made by Seirin Corporation). The following acupoints will be used: HT 7 (Shen Men), PC 6 (Nei Guan), LU 9 (Tai yuan), LI 4 (He Gu), SP 3 (Tai Bai,) ST 44 (Nei ting), LIV 3 (Tai Chong). The treatment will use bilateral acupuncture Interventions will be given on day 1, 3, and 5 after patient's enrolment.
Chronic pain is defined by a daily pain since more than 3 months. CP is different of acute pain because of their mechanisms, treatments and therapeutic objectives. CP is associated with an alteration of quality of life with psychological, social and economic consequences. The prevalence of CP in France is 15%. In ED, the rate of CP in patients with acute pain was around 40%. Patients with CP come more frequently to ED than patients without CP. Their use of care structures, particularly ED, is all the more frequent that their disability is important. The satisfaction of these patients in ED is associated with age, nature of pain, wait duration, realisation of imaging, and administration of painkillers and relieving of pain. The reasons why these patients go to ED were pain exacerbation, inadequate strategy of coping, severity of disease and sometime despair associated with stress or anxiety. Currently the investigators do not know if these managements in ED are adequate or not. And finally the investigators do not know whether the satisfaction about their ED management is different from patients without CP. The investigators are going to collect data about all patients admitted in ED with the objective to compare the satisfaction between patients with CP and patients without CP. The follow up will be restricted to the area of ED. The last data will be collected just before the exit from ED.
INTRODUCTION: Acute pain in the right lower quadrant during pregnancy is difficult to approach and acute appendicitis must be excluded. The complication rate in pregnant acute appendicitis increases as a result of delayed diagnosis due to physiological and anatomic changes. The systemic immune inflammatory index (SII), which includes several inflammatory tests, is considered to be a good indicator of acute inflammation. The aim of the present study was to investigate the diagnostic value of SII in the diagnosis of acute appendicitis and complicated appendicitis in pregnant women.
MATERIAL-METHOD: This was designed as a retrospective, single-center case-control study. This study was performed in pregnant women over 12 weeks of gestation who were diagnosed with acute appendicitis as indicated by pathology report and met the inclusion criteria. Vital parameters, demographic characteristics, laboratory values, presence of complicated appendicitis, and pathology reports were taken into analysis.
RESULTS: The present study was performed with 76 pregnant women, including 38 pregnant women with acute appendicitis and 38 pregnant women with healthy controls. SII had a sensitivity of 82.0% and specificity of 66.7% with a cut-off value of 840.13 in pregnant acute appendicitis cases (AUC: 0.790; 95% CI: 0.686-0.984; p < 0.001) and SII level was significantly higher in complicated appendicitis cases with a sensitivity and specificity of 66.7% and 91.3%, respectively, with a cut-off value of 2301.66 (AUC: 0.812; 95% CI: 0.665-0.958; p = 0.001).
CONCLUSION: SII is a cost-effective, rapid, easily calculated, and powerful marker that can be used for the diagnosis of both acute and complicated appendicitis in pregnant patients.
The invention discloses an application of an inflammation-diminishing and pain-relieving external medicine as an oral agent. The method comprises the following specific steps: taking 10-80 parts of hedyotis diffusa, 5-10 parts of scorpion, 5-10 parts of spiders, 10-30 parts of toads and 15-35 parts of centipede which are naturally dried, processing the materials into powder respectively, mixing evenly, and packaging 10 g of the powder in each bag. For patients with tumors and ulcerative carbuncles, which grow in digestive tracts, livers, gallbladders, spleens and pancreatic organs, a small dose of the external medicine is taken in the beginning, the external medicine is orally taken twice a day, and a bag of the external medicine is taken each time. The number of bags can be gradually increased to be three according to the dose required for treatment and the physical situation. The oral medicine can be independently used and also can be cooperatively used with other external medicines. The medicine has the advantages that a brand-new method for applying an external medicine component to oral treatment is provided, and the medicine is applied to the tumors and the ulcerative carbuncles, which grow in the digestive tracts, the livers, the gallbladders, the spleens and the pancreatic organs.
BACKGROUND: Reverse Takotsubo cardiomyopathy (TTC) is a rare variant of stress cardiomyopathy, characterized by basal akinesia with apical sparing. To our knowledge, this case is the first reported in the literature of intraoperative reverse TTC (rTTC) in liver transplantation.
CASE: After a thorough workup, a 19-year-old man, diagnosed with extrahepatic biliary atresia, was taken up for living-related donor liver transplantation. The patient developed intraoperative rTTC. This case report describes the challenges and successful management of this cardiomyopathy intraoperatively and postoperatively.
CONCLUSION: Intraoperative rTTC is challenging and requires aggressive and immediate hemodynamic and pharmacological management, along with supportive treatment and management of complications. This case report describes the challenges and successful management of this cardiomyopathy intraoperatively and postoperatively. To our knowledge, this case is the first reported in the literature of intraoperative rTTC in liver transplantation.
For this project, 40 patients with COPD will be recruited in 2 centres (in the Institute of Cardiology and Pneumology of Quebec and in the Chest Institute of Montreal). For each patient, three visits will be performed. During the first visit, baseline pulmonary function and maximal exercise capacity will be evaluated and the patients will be familiarized with step test proceedings. Between the different visits, a 3-7 days period will be respected. During the second and the third visits, 4 step tests will be performed at 4 different rates, following one of the two conditions (placebo or bronchodilatation). This project will propose two randomization levels. The first randomization will be relative to the choice of the condition used during the second visit (placebo ou bronchodilatation) and the second one for the rates order (14, 16, 20, 24 steps/min). During each performed exercise, cardiorespiratory and pulmonary parameters will be measured using a portable system.
Teratogenic Effects  
Pregnancy category B  
Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. Reproduction studies have been performed in rats at doses up to five times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to metronidazole. No fetotoxicity was observed when metronidazole was administered orally to pregnant mice at 20 mg/kg/day, approximately one and a half times the most frequently recommended human dose (750 mg/day) based on mg/kg body weight; however in a single small study where the drug was administered intraperitoneally, some intrauterine deaths were observed. The relationship of these findings to the drug is unknown. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, and because metronidazole is a carcinogen in rodents, this drug should be used during pregnancy only if clearly needed.

Use of metronidazole for trichomoniasis during pregnancy should be restricted to those in whom alternative treatment has been inadequate. Use of metronidazole for trichomoniasis in pregnancy should be carefully evaluated because metronidazole crosses the placental barrier and its effects on the human fetal organogenesis are not known (see above).
PURPOSE:To obtain surface-modified calcium hydrogenphosphate having characteristics as an abrasive for dentifrice such as good flavor and crispness and also having improved stability to fluorine by coating the surface of calcium hydrogenphosphate with hydroxyapatite. CONSTITUTION:Calcium hydrogenphosphate is brought into contact with an alkali metal or alkaline earth metal hydroxide or NH3 in an aq. suspension to coat the surface of the calcium hydrogenphosphate with 1-90wt.% hydroxyapatite. The concn. of the calcium hydrogenphosphate in the aq. suspension is <=80wt.%, preferably 50wt.%. The alkali is used as 2-8wt.% soln. in case of NaOH or KOH or as 10-30wt.% soln. in case of NH3.
The invention discloses a traditional Chinese medicine composition for treating radioactive spinal-form encephalomyelopathy. The traditional Chinese medicine considers that the disease is represented as neck spinal cord traverse damage of different degrees. Head drop electrical sensation disease has the clinical manifestation of progressivity, ascending and symmetry. This type of symptom is discriminated by traditional Chinese medicine as being caused by spleen deficiency, damp obstruction and meridian estrangement. Thus, traditional Chinese medicine of corncob, beautiful galangal fruit, trema cannabina, Siberian elm bark, fructus gleditsiae, calamus, pinellia ternate, edible tulip, antares grass root and rice galingale herb with functions of tonifying spleen, eliminating dampness and removing phlegm and dredging collaterals are prepared to be traditional Chinese medicine decoction. A clinical test proves that the curative effect is remarkable, the total effective rate of treatment group is 95%, the total effective rate of control group is 75%, the total effective rate of the treatment group is obviously higher than that of the control group; besides, the traditional Chinese medicine composition has no toxic and side effect, and is low in treatment cost and worthy of clinic popularization and application.
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested and indigestible polysaccharides. SCFAs play an important role in regulating intestinal energy metabolism and maintaining the homeostasis of the intestinal environment and also play an important regulatory role in organs and tissues outside the gut. In recent years, many studies have shown that SCFAs can regulate inflammation and affect host health, and two main signaling mechanisms have also been identified: the activation of G-protein coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC). In addition, a growing body of evidence highlights the importance of every SCFA in influencing health maintenance and disease development. In this review, we summarized the recent advances concerning the biological properties of SCFAs and their signaling pathways in inflammation and body health. Hopefully, it can provide a systematic theoretical basis for the nutritional prevention and treatment of human diseases.
BACKGROUND: Atrial fibrillation (AF) is often asymptomatic and thus under-observed. Given the high risks of stroke and heart failure among patients with AF, early prediction and effective management are crucial. Given the prevalence of obstructive sleep apnea among AF patients, electrocardiogram (ECG) analysis from polysomnography (PSG) offers a unique opportunity for early AF prediction. Our aim is to identify individuals at high risk of AF development from single‑lead ECGs during standard PSG.
METHODS: We analyzed 18,782 single‑lead ECG recordings from 13,609 subjects undergoing PSG at the Massachusetts General Hospital sleep laboratory. AF presence was identified using ICD-9/10 codes. The dataset included 15,913 recordings without AF history and 2054 recordings from patients diagnosed with AF between one month to fifteen years post-PSG. Data were partitioned into training, validation, and test cohorts ensuring that individual patients remained exclusive to each cohort. The test set was held out during the training process. We employed two different methods for feature extraction to build a final model for AF prediction: Extraction of hand-crafted ECG features and a deep learning method. For extraction of ECG-hand-crafted features, recordings were split into 30-s windows, and those with a signal quality index (SQI) below 0.95 were discarded. From each remaining window, 150 features were extracted from the time, frequency, time-frequency domains, and phase-space reconstructions of the ECG. A compilation of 12 statistical features summarized these window-specific features per recording, resulting in 1800 features (12 × 150). A pre-trained deep neural network from the PhysioNet Challenge 2021 was updated using transfer learning to discriminate recordings with and without AF. The model processed PSG ECGs in 16-s windows to generate AF probabilities, from which 13 statistical features were extracted. Combining 1800 features from feature extraction with 13 from the deep learning model, we performed a feature selection and subsequently trained a shallow neural network to predict future AF and evaluated its performance on the test cohort.
RESULTS: On the test set, our model exhibited sensitivity, specificity, and precision of 0.67, 0.81, and 0.3, respectively, for AF prediction. Survival analysis revealed a hazard ratio of 8.36 (p-value: 1.93 × 10-52) for AF outcomes using the log-rank test.
CONCLUSIONS: Our proposed ECG analysis method, utilizing overnight PSG data, shows promise in AF prediction despite modest precision, suggesting false positives. This approach could enable low-cost screening and proactive treatment for high-risk patients. Refinements, including additional physiological parameters, may reduce false positives, enhancing clinical utility and accuracy.
Liver fibrosis refers to the formation of scar tissue in the liver when inflammation persists over a long period. Assessing liver fibrosis is crucial for predicting the prognosis of chronic liver disease and managing patients with these conditions. Although a liver biopsy remains the gold standard for assessing liver fibrosis, it is limited by its invasive nature. Consequently, continuous efforts have been made to develop non-invasive methods for evaluating liver fibrosis, including imaging techniques and serum biomarkers. Vibration-controlled transient elastography (VCTE), a representative non-invasive imaging technique, has been used widely for liver fibrosis assessment since its introduction in 2003. This paper discusses the principles and methods of measurement, the advantages and disadvantages, and the considerations for interpreting VCTE based on the 2024 KASL Clinical Practice Guidelines for Non-invasive Tests to Assess Liver Fibrosis in Chronic Liver Disease. In addition, the diagnostic utility of VCTE in chronic viral hepatitis is reviewed.
Patients will be asked to have a HbA1c test in the clinic with a venous draw and then either fingerprick or upper arm draw. They will do the latter again at home.
Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Moreover, the pathophysiological processes underlying KC have not been fully elucidated with proposed mechanisms to include proteolytic degradation in the corneal stroma, oxidative damage, epithelial mechanical injury, immunological factors, and genetic factors. However, Hormonal imbalances may be associated with KC as it affects the corneal metabolism. Furthermore, thyroid gland dysfunction (TGD) can frequently associated with eye diseases such as Graves disease. Previous studies investigated the association between TGD and KC. Interestingly, thyroxine (T4) is important for corneal dehydration and transparency during embryonic development and regulates the synthesis of keratin sulfate proteoglycan in the chicken. T4 receptors (T4Rs) have been found in the lacrimal gland, confirming that the tear producing gland is a target organ of T4. T4 level was elevated in the tears of patients with KC. Hence, in this study, we aim to investigate the clinical association between TGD and KC.