anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
There is an urgent need to understand the lasting impact of COVID-19 on the cardiopulmonary system to improve physical function and prevent long-lasting disability. Pertinent knowledge gaps regarding the post-recovery physiology driving any impairments need to be addressed to improve the quality of life in Veterans with prior SARS-CoV-2 infection. Further, it is important to devise successful rehabilitation strategies that can be safely conducted in a Veteran's home. Hence, the investigators propose to utilize VA Video Connect to deliver a home based, supervised group exercise program to Veteran COVID-19 survivors. The objective of this exercise trial is to determine the influence of COVID-19 on cardiorespiratory fitness, pulmonary and physical function and to investigate the effect of a home-based exercise tele-rehabilitation on these outcomes. The study design includes rural and urban sites and investigators with a history of VA rehabilitation collaboration. Moreover, the investigators will explore healthcare disparities related to COVID-19 which are associated with functional decline and may affect sustainability of exercise rehabilitation strategies deployed, if necessary, under social distancing restrictions.
A composition of a compound represented generically by FIG. 1A for use in substance-assisted therapy. A method of changing neurotransmission, by administering a pharmaceutically effective amount of a compound of FIG. 1A to a mammal, interacting with serotonin 5-HT2A receptors in the mammal, in particular also human beings, and inducing psychoactive effects. A method of treating an individual, by administering a pharmaceutically effective amount of a compound of FIG. 1A to the individual and treating the individual.
<P>PROBLEM TO BE SOLVED: To provide a new gene which involves in a neuralizing induction in spinal animals and its protein and to provide a method for utilize the gene and the protein.  <P>SOLUTION: An XMAN1 gene which involves in the neuralizing induction of an animal cap of Xenopus laevis is isolated and structures of the XMAN1 gene and an XMAN1 protein are determined. A molecular mechanism of morphogenesis by neuralizing induction in the spinal animals is elucidated through a functional analysis of the XMAN1 gene and the XMAN1 protein. A human MAN1 which is a human homologue protein of the XMAN1 protein and its gene can similarly be utilized. The present invention further enables application of therapeutic agents and a therapeutic method for nervous system disorders.  <P>COPYRIGHT: (C)2004,JPO
A total of 300 patients are expected to include in this group. And the cardiac adverse reactions related to immune checkpoint inhibitor will be observed.
BACKGROUND: To explore the learning curve of single center laparoscopic pancreaticoduodenectomy (LPD) and evaluate the safety and efficacy of the operation at different stages.
METHODS: A detailed review was conducted on the clinical data of 120 cases of laparoscopic pancreatoduodenectomy performed by the same surgeon between June 2018 and June 2022. Cases that did not provide insights into the learning curve of the procedure were excluded. The cumulative sum (CUSUM) analysis and the best fitting curve methods were employed to delineate the learning curve based on operation time and intraoperative blood loss. The study further evaluated the number of surgeries required to traverse the learning curve. Outcome measures, including operation time, intraoperative blood loss, length of stay, complications, and other relevant indicators, were extracted and compared across different phases of the learning curve.
RESULT: The maximum turning point of the fitting curve was found in 35 cases by the cumulative sum method of operation time, after which the learning curve could be considered to have passed. The fitting curve obtained by the cumulative sum method of intraoperative blood loss was stable in 30 cases and proficient in 60 cases, which was basically consistent with the fitting curve of operation time. Taking 35 cases as the boundary, the learning curve is divided into learning improvement stage and mastering stage. There was no statistical significance in the general data of the two stage patients (P > 0.05). Hospitalization days decreased from 19 to 15 days (P < 0.05);Pancreatic fistula decreased from 20.0% of grade B and 8.6% of grade C to 7.1% of grade B and 3.5% of grade C (P < 0.05), and the operative time decreased from (376.9 ± 48.2) minutes to (294.4 ± 18.7) minutes (P < 0.05). Intraoperative blood loss decreased from 375 to 241 ml (P < 0.05).
CONCLUSION: Thirty-five patients with LPD can reach the proficiency stage and the perioperative indexes can be improved.
FIELD: pharmaceutical technology. SUBSTANCE: material comprises a filling agent and erythritol in the ratio of a filling agent to erythritol = 5-100 wt. %. A filling agent comprises one or more organic filling agents and/or one or more inorganic filling agents. An organic filing agent is taken among starch, cellulose and sugar alcohol. An inorganic solvent is taken among synthetic hydrotalcite, precipitated calcium carbonate and anhydrous calcium dibasic phosphate. Quickly decomposing, pressed materials show high capacity to disintegration and dissolving in mouth cavity or water that ensures to avoid difficulty in intake. Simultaneously, materials show high hardness and therefore they show good stability in storage in the process of production and delivery. Tablets comprising novel pressed materials are useful for adults, children or patients with difficulties in swallowing. EFFECT: improved and valuable properties of materials. 22 cl, 20 tbl, 15 ex
Treatment phase will consist of four treatment visits separated by 14 (+/- 1) days between visits. Each treatment sequence consists of a single dose of treatment each of the 4 treatments.
The investigators propose a randomized controlled trial to assess baseline maternal knowledge of and attitudes toward commercial prenatal genetic testing laboratories' genetic privacy practices, and to determine whether a brief educational intervention alters these attitudes. Pregnant women undergoing specialized fetal anatomic ultrasound surveys at Women and Infants' maternal fetal medicine prenatal diagnostic imaging centers will be recruited to participate. Volunteers will be randomized to receive either standard education about prenatal genetic testing or standard education plus additional education about federal genetic privacy protections. Next, the participants view the educational materials to which they were randomized. Finally, all volunteers will take the same survey, which will assess baseline demographic variables as well as their knowledge of and attitudes toward broad sharing of data obtained from prenatal genetic testing. Once finished with the survey, volunteers will have completed their participation in this study.
Leronlimab (PRO 140) will be administered subcutaneously at a weekly dose of 700 mg in combination with staring dose of 80 mg Regorafenib at first week of the Cycle 1, followed by escalation of Regorafenib dose to 120 mg and 160 mg in second and third weeks of Cycle 1, respectively. No Regorafenib will be administered during the fourth week.
BACKGROUND: Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated with pathological angiogenesis.
RESULTS: Here, we show that a feedback loop between H3K9 lactylation (H3K9la) and histone deacetylase 2 (HDAC2) in endothelial cells drives VEGF-induced angiogenesis. We find that the H3K9la levels are upregulated in endothelial cells in response to VEGF stimulation. Pharmacological inhibition of glycolysis decreases H3K9 lactylation and attenuates neovascularization. CUT& Tag analysis reveals that H3K9la is enriched at the promoters of a set of angiogenic genes and promotes their transcription. Interestingly, we find that hyperlactylation of H3K9 inhibits expression of the lactylation eraser HDAC2, whereas overexpression of HDAC2 decreases H3K9 lactylation and suppresses angiogenesis.
CONCLUSIONS: Collectively, our study illustrates that H3K9la is important for VEGF-induced angiogenesis, and interruption of the H3K9la/HDAC2 feedback loop may represent a novel therapeutic method for treating pathological neovascularization.
Acute pancreatitis (AP) is one of the most common gastrointestinal diseases. Bile acids (BAs) were proposed to be a cause of AP nearly 170 years ago, though the underlying mechanisms remain unclear. Here, we report that two G protein-coupled receptors, GPR39 and GHSR, mediated cellular responses to BAs. Our results revealed GPR39 as an evolutionarily conserved receptor for BAs, particularly 3-O-sulfated lithocholic acids. In cultured cell lines, GPR39 is sufficient for BA-induced Ca2+ elevation. In pancreatic acinar cells, GPR39 mediated BA-induced Ca2+ elevation and necrosis. Furthermore, AP induced by BAs was significantly reduced in GPR39 knockout mice. Our findings provide in vitro and in vivo evidence demonstrating that GPR39 is necessary and sufficient to mediate BA signaling, highlighting its involvement in biliary AP pathogenesis, and suggesting it as a promising therapeutic target for biliary AP.
Isolation comprises incubating low-density lipoprotein (LDL) receptors with a labelled form of a ligand (I) in the presence of the test substance, and measuring the deg. of binding. (I) is material from a rhino-virus of the 'small rhino-virus receptor gp.' (J.Virol.,51,340,1984). Also claimed are the use of (I) for inhibiting the binding of physiological LDL ligands; a method for determining LDL receptors, comprising labelling (I), incubating it with the test sample, and measuring the deg. of binding of the labelled (I); and a method for delivery of a therapeutically active substance (II) into cells bearing LDL receptors, comprising coupling (I) with (II) to form a conjugate, and supplying the conjugate to the corresp. cell material. USE - The 1st method may be used to screen for substances capable of inhibiting binding of rhinoviruses or other ligands to LDL receptors. Method 2 may be used for the analysis, e.g., of cholesterol metabolism.
The invention belongs to the field of natural extracts, and discloses a natural extract for soothing skin and improving skin quality and application thereof. The active ingredients of the natural extract are flower extracts of safflower, albizia flower, paris polyphylla, lonicera confusa, tropaeolum majus, peony and polygala japonica. The invention selects various flowers as raw materials in a breakthrough way and extracts the essence in the flowers. In the formula, safflower is taken as a monarch drug, so that the effects of consolidating body resistance, promoting blood circulation, relieving depression and calming the nerves are achieved; the albizia flower and the paris polyphylla are used as ministerial drugs and have the effects of diminishing inflammation, relieving pain, relieving and soothing the nerves; flos Lonicerae, flos Trollii, and flos moutan can be used for dispelling wind and heat, and soothing and relieving itching; baijin Hua is used as a guide to clear away heat and toxic material, remove red and relieve swelling. The extracts have synergistic effect, and have good antiinflammatory and antioxidant effects. Has good skin-care effect aiming at immediate symptom relief of sensitive skin and long-acting barrier consolidation. The product has natural flower fragrance, gives people natural joyful feeling when in use, relieves mental stress, and can better improve sensitive skin.
An edible medication carrier for animal comprises a body forming a receiving space and a cover. The body and the cover are made of substances of animal feeds. The body shows an outside configuration resembling animal feed available in the market. The body and the cover respectively comprise first and second wall that are in an annular form and correspond to each other. The first and second walls respectively comprise first and second threading units. Medication can be deposited in the receiving space and, then, through the first and second threading units mating each other, the cover is fixed to the body to retain the medication inside the body, but showing the same shape and smell as animal feed for easy mixture with animal feeds for feeding animals and making it hard to distinguish by the animals so that animals may easily take the medication.
PURPOSE:Latex particles carrying an immunogen substance are administered parenterally to an animal to effect the immune resonance, and the objective antibody to said immunogen substance is separated from the animal. CONSTITUTION:An immunogen substance (e.g. deoxyribonucleic acid, grouop polysaccharide of A-group hemolytic streptococcus, Klebsiella pneumoniae, Neisseria meningitidis, etc.) is supported on solid particles of synthetic or natural latex [e.g. synthetic latex such as styrene. divinylbenzene, vinyl chloride, etc., and natural latex such as latex of Hevea brasiliensis, etc., having average particle diameter of 0.01-10mum, preferably 0.02-7mum], and the latex is administered parenterally to an animal to induce immue response to the animal. The corresponding antibody is separated from the animal. EFFECT:Even a substance having low immunogenicity in itself can be converted to one exhibiting high immunogenicity, and there is no production of the antibody against the carrier.
Comprehensive and non-invasive preoperative molecular diagnosis is important for prognostic and therapy decision-making in adult-type diffuse gliomas. We employed a deep learning method for automatic segmentation of brain gliomas directly from conventional magnetic resonance imaging (MRI) scans of the tumor core and peritumoral edema regions based on available glioma MRI data provided in the BraTS2021. Three-dimensional volumes of interest were segmented from 424 cases of glioma imaging data retrospectively obtained from two medical centers using the segmentation method and radiomic features were extracted. We developed a subtype prediction model based on extracted radiomic features and analyzed significance and correlations between glioma morphological characteristics and pathological features using data from patients with adult-type diffuse glioma. The automated segmentation achieved mean Dice scores of 0.884 and 0.889 for the tumor core and whole tumor, respectively. The area under the receiver operating characteristic curve for the prediction of adult-type diffuse gliomas subtypes was 0.945. "Glioblastoma, IDH-wildtype", "Astrocytoma, IDH-mutant", and "Oligodendroglioma, IDH-mutant, 1p/19q-coded" showed AUCs of 0.96, 0.914, and 0.961, respectively, for subtype prediction. Glioma morphological characteristics, molecular and pathological levels, and clinical data showed significant differences and correlations. An automatic segmentation model for gliomas based on 3D U-Nets was developed, and the prediction model for gliomas built using the parameters obtained from the automatic segmentation model showed high overall performance.
Acute myocardial infarction, often associated with ischemia/reperfusion injury (I/R), is a leading cause of death worldwide. Although the endogenous tryptophan metabolite kynurenic acid (KYNA) has been shown to exert protection against I/R injury, its mechanism of action at the cellular and molecular level is not well understood yet. Therefore, we examined the potential involvement of antiapoptotic mechanisms, as well as N-methyl-D-aspartate (NMDA) receptor modulation in the protective effect of KYNA in cardiac cells exposed to simulated I/R (SI/R). KYNA was shown to attenuate cell death induced by SI/R dose-dependently in H9c2 cells or primary rat cardiomyocytes. Analysis of morphological and molecular markers of apoptosis (i.e., membrane blebbing, apoptotic nuclear morphology, DNA double-strand breaks, activation of caspases) revealed considerably increased apoptotic activity in cardiac cells undergoing SI/R. The investigated apoptotic markers were substantially improved by treatment with the cytoprotective dose of KYNA. Although cardiac cells were shown to express NMDA receptors, another NMDA antagonist structurally different from KYNA was unable to protect against SI/R-induced cell death. Our findings provide evidence that the protective effect of KYNA against SI/R-induced cardiac cell injury involves antiapoptotic mechanisms, that seem to evoke independently of NMDA receptor signaling.
Patients in the control group receive standard of care. Both intervention and control groups receive standard monitoring and coaching, including pre-scheduled checks for side effects before chemotherapy. Patients in both groups are asked to complete questionnaires measuring the impact on HRQoL, anxiety, distress, and patient empowerment at baseline, 10 weeks, and 20 weeks post-chemotherapy initiation.
Although coronaviruses (CoV) cause mild infections in the community, such as colds, they can also cause more severe infections. There are many subspecies of coronaviruses that can pass from animals to humans and can be transmitted between humans. One of these subspecies is COVID-19 (severe acute respiratory syndrome coronavirus 2), or SARS-CoV-2, and has made a worldwide pandemic from the beginning of 2020. Many countries are taking measures to protect everyone, including those in the risk group, to prevent disease in large groups and balance hospital bed capacities against the COVID-19 pandemic. Among these measures; There is an incentive for public health practices such as contact isolation, quarantine, frequent hand washing, not going out of the house unless needed, and social distance. In the investigator's country, preventive and therapeutic measures (such as quarantine, social distance) are taken against the COVID-19 pandemic and the public is constantly informed in this context. In this process, going out of the house, going to the hospital and being in the hospital brings with it the anxiety to get sick. Despite all these, there are compulsory situations requiring people to be in the hospital during the pandemic period. One of them is to give birth and then the baby stays in the hospital due to the need for intensive care.

Although it is a pleasant feeling for women who have just given birth to feel the feeling of motherhood, to embrace the baby, to attach it to the baby, adapting to the new situation with the accompanying responsibilities can force the mother psychologically In the period when the feeling of motherhood begins, the hospitalization of the baby for any reason and the separation of the mother and the baby may be an additional source of stress. The fact that this process is experienced during the pandemic period can increase the anxiety and stress in the mother much more. It is important for nurses to determine the needs of mothers whose babies are in the neonatal intensive care unit (NICU) during their pandemic, in order to reduce their anxiety and anxiety by applying appropriate nursing approach. This study was planned to determine the anxiety and anxiety levels of mothers who had a baby in the NICU during Coronavirus disease pandemic and the factors affecting them.
Quinine has been used worldwide for hundreds of years in the treatment of malaria. Thorough searches of the published literature identified over 1300 references to the treatment of malaria with quinine, and from these, 21 randomized, active-controlled studies were identified which evaluated oral quinine monotherapy or combination therapy for treatment of uncomplicated P. falciparum malaria. Over 2900 patients from malaria-endemic areas were enrolled in these studies, and more than 1400 patients received oral quinine. The following conclusions were drawn from review of these studies:

In areas where multi-drug resistance of P. falciparum is increasing, such as Southeast Asia, cure rates with 7 days of oral quinine monotherapy were at least 80%; while cure rates for 7 days of oral quinine combined with an antimicrobial agent (tetracycline or clindamycin) were greater than 90%. In areas where multi-drug resistance of the parasite was not as widespread, cure rates with 7 days of quinine monotherapy ranged from 86 to 100%. Cure was defined as initial clearing of parasitemia within 7 days without recrudescence by day 28 after treatment initiation. P. falciparum malaria that is clinically resistant to quinine has been reported in some areas of South America, Southeast Asia, and Bangladesh, and quinine may not be as effective in those areas.

Completion of a 7-day oral quinine treatment regimen may be limited by drug intolerance, and shorter courses (3 days) of quinine combination therapy have been used. However, the published data from randomized, controlled clinical trials for shorter regimens of oral quinine in conjunction with tetracycline, doxycycline, or clindamycin for treatment of uncomplicated P. falciparum malaria is limited, and these shorter course combination regimens may not be as effective as the longer regimens.
The invention discloses recombinant humanized I+III type collagen, which is formed by splicing a humanized I type collagen truncated body and a humanized III type collagen truncated body, wherein the amino acid sequence of the humanized I type collagen truncated body is at least one of SEQ ID No. 1-SEQ ID No.7, and the amino acid sequence of the humanized III type collagen truncated body is at least one of SEQ ID No. 8-SEQ ID No. 32. The invention selects the sequences of the human type I and type III collagen, which are natural human amino acid sequences, ensures the stability of the whole sequence and does not generate immune rejection reaction. The recombinant humanized I+III type collagen has the function of promoting cell proliferation, has good water solubility and stable quality, and can be widely applied to the fields of skin care products, skin repair dressings, medical cosmetology, health care foods and the like.
The participants in this arm were asked to refrain from changing their physical activity over the 12 weeks and maintain any strategies typically used to manage knee and/or hip pain. Since it is known that exercise is beneficial for pain management and strengthening in knee OA, participants randomized to the no exercise group were offered a free exercise pass following completion of the study. Measurements were obtained at baseline (before intervention) and at follow-up (following intervention). Outcomes included clinical mobility; pain; isometric leg strength; cardiovascular fitness; and resilience.
PURPOSE:To provide an immune-reinforcing, infection-preventing agent useful for various diseases and various pathogenic microorganism-infected diseases caused by the depression in the immunological ability of a living body by incorporating albumin into the agent. CONSTITUTION:Raw albumen, all egg powder, albumen powder, a digestive enzyme-treated albumen fraction or albumen-constituting component as an active ingredient is compounded with conventional carrier, excipient, buffer and other additives and the composition is formed in the objective agent by a conventional method. The agent may be prepared in an oral administration shape such as tablet, capsule, powder, granule or syrup. The albumen is administered in a dose of >=1mg, preferably 10mg-2g, per kg of body a day in a case of the albumen powder. The agent may be added to foods such as water, milk, artificial milk and functional foods, e.g. healthy foods, or to feeds.