anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: The treatment of unilateral amblyopia involves refractive adaptation, occlusion therapy or penalization with atropine drops. However, in recent years, the use of binocular digital therapy has shown promising results. Aim of this systematic review was to evaluate the effectiveness of binocular treatment of amblyopia compared with standard treatments or placebo therapy.
METHODS: This systematic review was conducted in accordance to PRISMA statement. Electronic literature was thoroughly searched for articles published between 2013 and May 2024, in the following electronic database; Pubmed, CENTRAL, MedlinePlus, Medline Europe, PLOS, Scopus, Clinicaltrials.gov. The review comprised randomized control trials (RCTs) including patients with unilateral amblyopia, who received binocular therapy or standard amblyopia or placebo treatment for more than two weeks and who had visual acuity assessment pre- and post-treatment. Only articles written in English were included. Risk of bias was assessed with the Rob2 tool, while study quality was evaluated with the modified Jadad scale.
RESULTS: Twenty RCTs, including 1769 patients, were incorporated into this systematic review. Twelve different types of binocular amblyopia treatments were identified and categorized into two main types. The first type involves the presentation of low-contrast images in the fellow eye, including stimuli presented only in the amblyopic eye. The second type combines this approach with complementary dichoptic deficits in the images presented to both eyes to encourage their simultaneous use.
CONCLUSION: Binocular amblyopia treatment has shown promising results in addressing unilateral anisometropic, strabismic or mixed type of amblyopia. Nevertheless, further randomized controlled trials are essential to establish the exact dosage, type and duration of binocular therapy as a standard component of amblyopia care.
PURPOSE: A cosmetic composition for wrinkle improvement is provided to eliminate side effects and improve anti-wrinkle effect. CONSTITUTION: A cosmetic composition for wrinkle improvement includes tannin and alum. The composition additionally includes Acorus gramineus Solander, Sinapis alba L. seeds, and Coconopsis lanceolata extract as herbal medicine. The weight ratio of the alum and tannin is 1-10 to 0.7-7. The extract of herbal medicine is included 1-10 weight % based on whole cosmetic composition. The weight ratio of the Acorus gramineus Solander to Sinapis alba L. seed to Coconopsis lanceolata extract is 1to 0.1-10 to 0.1-10. The extract of herbal medicine is obtained by extracting the herbal medicine using water or ethanol. The cosmetic composition can be in toning, essence, lotion, cream, pack, ointment, foundation, soap, shampoo, cleansing, or powder form.
In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), acetaminophen and codeine phosphate oral solution may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure. Monitor such patients for signs of sedation and respiratory depression, particularly when initiating therapy with acetaminophen and codeine phosphate oral solution.

Opioids may also obscure the clinical course in a patient with a head injury. Avoid the use of acetaminophen and codeine phosphate oral solution in patients with impaired consciousness or coma.

### Hypersensitivity/Anaphylaxis

There have been post-marketing reports of hypersensitivity and anaphylaxis associated with the use of acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue acetaminophen and codeine phosphate oral solution immediately and seek medical care if they experience these symptoms. Do not prescribe acetaminophen and codeine phosphate oral solution for patients with acetaminophen allergy [see PRECAUTIONS; Information for Patients/Caregivers].
Glioblastoma multiforme (GBM) is a highly vascularised tumour. Previous studies have shown that prostate-specific membrane antigen (PSMA) is robustly expressed by the tumour vascular endothelium of GBM and thus could be an interesting target for diagnosis and treatment.

Several groups have focused on the development of 18F-labeled PSMA ligands for PET imaging. 18F as a radionuclide has several advantages over 68Ga. Due to the longer half-life compared (110 min for 18F compared to 68 min for 68Ga) allows for centralized production and distribution to greater areas. Furthermore, multiple doses of 18F can be produced in one synthesis, while each gallium generator provides only one or two elutions per day. Moreover, due to the decreased positron energy (0.65 MeV for 18F compared to 1.90 MeV for 68Ga) imaging resolution may be higher. The first generation of 18F-PSMA ligands, such as 18F-DCFBC, suffered from high background due to slow blood clearance. The second generation 18F-DCFPyL PSMA ligand has a fast elimination via the urinary route and showed high tumor-to-blood ratios. Benesova et al developed the 177Lu-DKFZ-61, which is suitable for labelling with both diagnostic 68Ga as well as therapeutic 177Lu (beta-emitting) or 225Ac (alpha-emitting), and Giesel at al developed 18F-PSMA-1007, which is structurally related to DKZF-617.

Since various studies have shown feasibility of PSMA imaging in brain lesions of patients with recurrent GBM, we want to extend these results in a cohort of patients with a first-diagnosed suspected GBM. We want to use the PET tracer 18F-PSMA-1007. If this technique can be implemented successfully, the added value of 18F-PSMA PET/CT for tumour grading and differential diagnosis could be investigated further in larger patient cohorts (especially with recurrent brain lesions). These studies will pave the way for further studies involving 177Lu-PSMA-based therapy, which is currently applied in patients with metastatic prostate cancer.
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I)   wherein radical values are determined in the invention claim and their pharmaceutically acceptable salts. Compounds are inhibitors of thrombin and can be used for modulation of thrombin function and as anticoagulating agents. Compounds show high biological availability also. EFFECT: valuable biological properties of inhibitors. 9 cl, 2 tbl, 47 ex
INTRODUCTION: A commercially available snake bite device was pilot tested for novel use as a method of hemostasis and wound repair at a noncompressible site in a live swine model. The device is light, is plastic, uses a hook-and-loop strap attachment, and is easily deployed. The device could offer a method for the field repair of an actively bleeding laceration at a noncompressible site in an austere environment.
MATERIALS AND METHODS: This was an interventional, prospective, controlled study in a large animal model. The study was approved by the Rhode Island Hospital Institutional Review Board (IRB) and the Animal Welfare Committee/Institutional Animal Care and Use Committee and the Lifespan Research Conflict of Interest Committee. Each animal acted as its own control. Blood loss was measured and compared between repairs of standardized incisions with and without the device's application. The lacerations were sutured closed. Two proceduralists alternated tasks of wound repair versus blood collection. Blood loss was measured by using gauze sponges to capture the blood during a 30-second free-bleeding period and during the repair itself. Using a one sample t-test (the expected difference in blood loss between the two incision repair methods = 0 if the null hypothesis were true), we calculated the mean difference in the deltas between the repair methods.
RESULTS: The mean delta difference was 3.1 g (SE ± 0.97). The t-test demonstrated that there was a significantly greater blood loss during the standard repair method, t(9) = 3.11, P < 0.01 than during the repair with the device in place (see Fig. 2). A statistical power analysis conducted showed that with a sample size of 10 animals, there was sufficient statistical power to detect this significant effect (β = 0.82, α < 0.05, one-tailed).
CONCLUSIONS: There was statistically significantly less blood loss during the repairs with the device's application. This feasibility experiment demonstrates that a commercially available snakebite device may be useful for hemostasis during laceration repair at anatomic sites not amenable to application of tourniquets or compressive dressings. Strengths of the study include the prospective controlled design, including the use of each animal as its own control; alternating proceduralists to account for any variability in suturing efficiency; and the statistical significance of the results despite the small number of subjects. One weakness is that the time required for each repair was not measured. The device's portability and reusability suggest applicability in austere medical environments. Future studies could include timing the repairs, using a skin stapler or wound adhesive instead of sutures, applying a hemostatic agent before the repair, and sequentially applying the device to wounds longer than the device.
The invention particularly discloses a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a medicine with the effect of preventing and treating fatty liver. The traditional Chinese medicine composition comprises the following raw material components: preparing radix et rhizoma Rhei, herba Gynostemmatis, semen Sinapis Albae and Mirabilitum. In addition, the composition also comprises sedum sarmentosum. The traditional Chinese medicine composition is prepared from four traditional Chinese medicines of prepared rhubarb, gynostemma pentaphylla, white mustard seed and mirabilite, and has excellent effects of reducing blood fat and preventing and treating fatty liver. In addition, the sedum sarmentosum is further added into the prepared rhubarb, the gynostemma pentaphylla, the white mustard seed and the mirabilite, so that the blood fat reducing effect and the fatty liver preventing and treating effect of the traditional Chinese medicine composition prepared from the sedum sarmentosum can be obviously improved. Compared with the traditional Chinese medicine for treating fatty liver in the prior art, the traditional Chinese medicine for treating fatty liver is greatly reduced in formula composition, free of precious medicines and toxic medicines, safe, reliable, low in technical risk, wide in market demand and obvious in economic and social benefits.
Anaesthetists insert epidurals or spinal anaesthetics (collectively called central neuraxial blocks) to patients during childbirth to provide pain relief and anaesthesia. A spinal anaesthetic involves the injection of pain relieving medicines directly into the sac of fluid that surrounds the spinal cord. An epidural uses a different technique to place a thin plastic tube into the fatty tissues that surround this sac. Spinal anaesthesia must be placed below where the spinal cord ends to avoid nerve trauma. Doctors have traditionally been taught to identify a safe level, by feeling the top of a patients hips and drawing an imaginary line between these two points across the patients back known as Tuffier's line. This identifies L4/5 interspace, below which anaesthetists avoids the termination of the spinal cord. The same blind "anatomical rule" is used throughout anaesthetics, whether the patient is male or female, young or old, pregnant or non-pregnant, supine or lateral, an approach that is clearly far from robust. The physiological changes of pregnancy such as fluid retention and weight gain can further make identification of the standard landmarks challenging. Advances in ultrasound technology have allowed direct visualisation of the bones in the back. Studies have shown that the conventional anatomical based method for locating the point of needle insertion is unreliable even amongst experienced anaesthetists.

Spinal or epidural anaesthesia can be performed with the patient either sitting or lying on their side. The investigators aim to determine whether a difference exists between the perceived mid-point of the L4/L5 intervertebral space, identified using manual demarcation of Tuffier's line, in these two positions. Ultrasound will then be used to ascertain the distance from the "true" midpoint.
Insulin peglispro (LY2605541) administered to participants with T1DM subcutaneously (SQ) once daily (QD) for 28 to 35 days in one of two treatment periods. Dose is based on participant's prestudy basal insulin dosing regimen. Insulin glargine administered to participants with T1DM SQ QD for 28 to 35 days in one of two treatment periods. Dose is based on participant's prestudy basal insulin dosing regimen. Participants continue to use mealtime insulin.
UST maintenance treatment assignment will be based on centrally-read colonoscopy (at Wk16). Participants with \<25% improvement in SES-CD score at Wk16 will be assigned to Q8 (8-weekly) treatment and will receive UST 90mg SC at Wk16. In contrast, participants with \>=25% improvement in SES-CD score at Wk16 will be assigned to Q12 treatment and will receive next UST dose (90 mg SC) at Wk20. At assessment visits (from Wk24 for participants assigned to the Q8 regimen or from Wk20 for the Q12 group) UST maintenance treatment (up to Wk 48) will be directed by T2T assessments. Participants meeting target will continue with same UST dosing frequency. The dosing frequency will be optimized for all participants failing to meet the target at assessment visit. Those previously on Q12 regimens will be adjusted to Q8 dosing; those previously on Q8 regimens will be adjusted to Q4 dosing. Participants subsequently failing to meet the target will not be able to adjust further and will leave the study.
The principal goal for the study is to examine the role gut flora plays in modulating metabolism of dietary trimethylamine nutrients in humans. We have recently shown that dietary intake of two trimethylamines abundant in animal products, carnitine and the choline group of phosphatidylcholine (PC), are mechanistically linked to cardiovascular disease risk. We wish to further explore the metabolism of these nutrients in humans, and to test the hypothesis that the intestinal micro flora (gut flora) plays a critical role in generation of metabolites from dietary carnitine and choline/PC linked to cardiometabolic disease. We further hypothesize that the production of specific metabolites of carnitine and choline/PC are influenced by the composition of gut flora, and these may be altered by the preceding dietary patterns of the subjects. We therefore wish to test whether dietary supplementation with carnitine and/or choline alters the metabolism of carnitine and choline/PC in subjects. We also hypothesize that transient suppression or modulation of gut flora via short-term broad spectrum antibiotic therapy, or by reconstitution of micro flora composition via probiotic therapy, in healthy subjects, can alter the metabolism of carnitine and choline/PC. We will also examine the impact of low dose aspirin on these pathways by examining subjects before versus after taking aspirin.
The invention relates to a method for preparing degradable nanoparticles with stimulus responsiveness based on a reactive block copolymer and application thereof, wherein the nanoparticles with stimulus responsiveness are prepared by taking polyethylene glycol-b- (2-vinyl-4, 4-dimethyl azlactone) (PEG-b-PVDMA) Block Copolymers (BCPs) as a reaction platform and are used for loading and controlling the release of molecular cargos. Microphase separation of PEG-b-PVDMA BCPs allows the construction of well-defined nanoparticles in aqueous solution. Azlactone groups in the PVDMA repeat units provide active sites for hydrophilicity and primary amine functionalization of BCPs. The hydrophilicity of PEG-b-PVDMA BCPs induces the reconstitution and degradation of self-assembled BCP nanoparticles. The functional primary amines can be conjugated to PEG-b-PVDMA BCPs to produce BCPs containing Azo and pyr. The nanoparticles of the present invention can bind to molecular cargo and release them under external stimuli, making azlactone-containing BCPs an attractive platform for the development of control vehicles.
During the study whenever you have an arm volume measurement using the Perometer, we will also measure the fluid in your arms using Bioimpedance Spectroscopy. These measurements are made by passing a harmless electrical signal of very low strength through your body to determine the difference in the amount of fluid in each arm. The test is simple and painless, and takes about 3 minutes. In addition, whenever you have an arm measurement, you will be asked to complete a questionnaire. While completing the questionnaire, you can skip any questions you do not wish to answer. The questionnaires will take about 10 minutes to complete. Arm measurements with the Perometer and Bioimpedance Spectroscopy and completion of the questionnaire will occur every 4-7 months when you are at MGH for regular medical visits.
The study will be a repeated measures design examining the between-subjects effect of intervention condition (values clarification, planning, and combined) on self-reported health goal progress and related outcomes at 1-week and 4-week follow-up, relative to baseline. Based on this design, participants will first be instructed to generate a health-related goal on which they want to make progress over the course of the next month (following procedures adapted from Little, 1993, and Sheldon \& Kasser, 1998; see details below). Participants will then be randomly assigned (using a random number table) to one of three intervention conditions: (1) values clarification, (2) planning, and (3) combined (values clarification + planning). All conditions are described in more detail below. Fifty-three participants will be randomized to each condition. Questionnaire measures assessing a variety of psychological variables as well as neuropsychological measures will be modeled as between-subject predictor and/or moderator variables of goal-consistent health behavior. Additionally, differences in self-concordance, goal commitment, and expectancies of success will be modeled as potential moderator and/or mediator variables.
This group only used conventional pathogen detection methods for the identification of infectious pathogens. Follow-up was conducted at the 1st, 2nd, 3rd, and 4th weeks after the diagnosis of severe pneumonia or sepsis. The conventional means of pathogen detection include, but are not limited to, fungal serology tests, cryptococcal capsular antigen detection, CMV-DNA tests, sputum smear microscopy, gamma interferon release assays, Xpert MTB/RIF, BLAF culture, blood and bone marrow cultures, radiological examinations, and histopathological examinations.
PROBLEM TO BE SOLVED: To obtain an amino acid sequence concerned with apoptosis and to provide a method for identifying the amino acid sequence. SOLUTION: A human REQUIEM polypeptide is provided. A DNA (RNA) encoding the REQUIEM is provided. A method for producing the polypeptide by a recombination method is disclosed. A method for using the REQUIEM is disclosed for treating viral infection, carcinogenesis and diseases in control of embryogeny and tissue homeostasis and susceptibility to diseases deficiency. A specific human-derived nucleic acid sequence may be used for an assay for confirming such susceptibility.
In a 2-year carcinogenicity study, rats were administered oral doses of dasatinib at 0.3, 1, and 3 mg/kg/day. The highest dose resulted in a plasma drug exposure (AUC) level approximately 60% of the human exposure at 100 mg once daily. Dasatinib induced a statistically significant increase in the combined incidence of squamous cell carcinomas and papillomas in the uterus and cervix of high-dose females and prostate adenoma in low-dose males.

Dasatinib was clastogenic when tested in vitro in Chinese hamster ovary cells, with and without metabolic activation. Dasatinib was not mutagenic when tested in an in vitro bacterial cell assay (Ames test) and was not genotoxic in an in vivo rat micronucleus study. 

Dasatinib did not affect mating or fertility in male and female rats at plasma drug exposure (AUC) similar to the human exposure at 100 mg daily. In repeat dose studies, administration of dasatinib resulted in reduced size and secretion of seminal vesicles, and immature prostate, seminal vesicle, and testis. The administration of dasatinib resulted in uterine inflammation and mineralization in monkeys, and cystic ovaries and ovarian hypertrophy in rodents.
BACKGROUND: Case history assessments are ubiquitously performed across various health professions for diagnostic purposes. Questionnaires are considered a valuable tool within this process. There is currently no standardized tool available to collect such information in the assessment of voice disorders. Conflicting advice from peak bodies and research evidence makes the process heterogenous, haphazard and difficult to compare findings.
OBJECTIVE: To systematically identify existing case history questionnaires available for general clinical practice and provide synthesis and analysis of the questions within.
METHODS: A scoping review was conducted across published and unpublished literature using the PRISMA Extension for Scoping Reviews framework. The broad search included research papers within six electronic databases, textbooks, online publishing sites, voice clinic websites and peak body websites. Search criteria were uniformly applied. Descriptive analysis and content analysis was conducted. At each stage, transparency and replicability was achieved through an independent review process.
RESULTS: Identified voice case history questionnaires were few (n = 23) with 80% from unpublished sources. A total of 581 unique questions were identified. No single question was common across all 23 questionnaires. The most frequently asked questions, excluding demographics, included medicines taken (n = 21), smoking (n = 20) and alcohol (n = 19). These questions were not reflected in the highest frequency categories: Health Status/Medical Conditions/Reports (n = 200), Vocal Symptoms (n = 88), Voice Use (n = 51) despite these categories representing 58% of all questions asked. Within the highest frequency category, the subcategory of Systemic Diseases was the highest, representing 19% of all questions within the category.
CONCLUSIONS: This study illuminates the similarities yet many differences that exist across identified voice case history questionnaires in terms of number of questions, number of categories, preference for question-type and structure. It demonstrates the need for standardization of a voice case history questionnaire which would potentially enable more accurate diagnosis and data comparison between voice clinics to aid future research.
<P>PROBLEM TO BE SOLVED: To efficiently group and manage image data of an object by using an ID for displaying object specification information.  <P>SOLUTION: When an object and an ID are photographed by using a digital camera, the time information of the photographing time is respectively recorded in object image data and ID image data as incidental data. An image data management apparatus identifies the ID image data from the object image data. Object image data having the time information of photographing time included in a prescribed time range around the photographing time indicated by the time information recorded as the incidental data of the ID image data as the incidental data are merged as one group. Further, character recognition processing for the identified ID image data is executed and object specification information related to the object which is displayed in the ID are converted into character data. The object specification information is added to respective object image data merged to the same group as the ID image data.  <P>COPYRIGHT: (C)2007,JPO&INPIT