anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invented paste is prepared by using budizhaze, xiaoyuyancao and shanghancao as raw medicines. Through 940 cases of clinical practice, the average effective rate comes up to 96.8%. The patient applies said paste on the navel, after 20-30 min. the temperature will begin to go down ordinarily. The result is especially remarkable for the child, the pain for being afraid of injection, taking medicine and infusion is completely avoided and the trouble of the treatment is decreased. Compared with the available technologies, the advantages of said invention are convenient for application, quickly bring down a fever and without side effect etc..
Sepsis and septic shock are critical medical conditions characterized by a systemic inflammatory response to infection, significantly contributing to global mortality rates. The progression to multiple organ dysfunction syndrome (MODS) represents the most severe complication of sepsis and markedly increases clinical mortality. Central to the pathophysiology of sepsis, endothelial cells play a crucial role in regulating microcirculation and maintaining barrier integrity across various organs and tissues. Recent studies have underscored the pivotal role of endothelial function in the development of sepsis-induced MODS. This review aims to provide a comprehensive overview of the pathophysiology of sepsis-induced MODS, with a specific focus on endothelial dysfunction. It also compiles compelling evidence regarding potential small molecules that could attenuate sepsis and subsequent multi-organ damage by modulating endothelial function. Thus, this review serves as an essential resource for clinical practitioners involved in the diagnosing, managing, and providing intensive care for sepsis and associated multi-organ injuries, emphasizing the importance of targeting endothelial cells to enhance outcomes of the patients.
In active rTMS, 10 Hz stimulations over left DLPFC occurred at a power of 110% of MT for 27-s intervals with 20s inter-train interval. 20 minutes were administered each day (Monday-Friday) for 8 consecutive weeks.
Participants randomized to the Engagement and Distraction condition will be asked to download and use the free TED Talk app (available for iOS and Android platforms). The app offers many videos of engaging and distracting presentations about technology, entertainment, and design. The research coordinator will work with the participant to create a customized list of Ted Talk videos, each lasting 6-12 minutes, based on participants' personal interests. Participants will be asked to listen to or watch at least one, and ideally two, presentations using the app daily for six weeks. The research coordinator will ask participants to complete weekly logs of their TED Talk app use via a Qualtrics survey sent via email.
The invention discloses a polygene fusion oncolytic adenovirus, which is based on an Adeasy vector system and is inserted with an sTGF beta RIIFc gene expression frame, an adenovirus replication regulatory gene sequence and a CD40L gene expression frame. The invention takes oncolytic adenovirus as a carrier, combines a treatment strategy of targeting soluble TGF-beta receptor II-Fc fusion protein and targeting CD40-CD40L, synergistically exerts the anti-tumor immune activation effect thereof and improves the treatment level of breast cancer. After local administration of tumor, tumor cells are killed by the oncolytic action; meanwhile, the continuously replicating virus can continuously secrete sTGF beta RIIFc and CD40L and inhibit a TGF beta signal pathway and CD40L. Can block TGF beta signal abnormally activated in tumor cells and inhibit tumor cell metastasis. Meanwhile, the CD40L can activate the anti-tumor immune response of the organism, inhibit the proliferation of tumor cells and promote the apoptosis of the tumor cells. The compound can synergistically play the roles of improving the tumor immune microenvironment and activating the anti-tumor immune response of the organism, and can play the role of oncolytic virus for a long time.
HCC occurs in the vast majority of cases in the context of cirrhosis. Cirrhosis is considered a pre-cancerous state, which justifies systematic screening for HCC. Screening currently relies on measurement of alpha-foetoprotein (AFP) levels and ultrasound scans every 4 to 6 months. However, AFP has poor sensitivity as a marker for HCC. We have recently shown that plasma proteasome levels have a higher sensitivity than HCC for detecting HCC in cirrhotic patients, particularly when the tumors are small and can still benefit from curative treatment. The hypothesis of the study is that plasma proteasome levels will decrease following curative treatment, and that proteasome levels could be used as a marker to detect early recurrence. The goal of this study is to determine whether plasma proteasome levels in cirrhotic patients with HCC decrease following curative treatment (radiofrequency, surgical resection, liver transplantation). Plasma proteasome levels will be measured before treatment and 3 months after treatment, then subsequently at 3 month intervals over one year following treatment. The variation of proteasome levels will be compared to AFP levels. The sensitivity of proteasome as a marker to detect tumor recurrence will be evaluated, and compared to AFP.
BACKGROUND: Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in the progression of ovarian cancer.
METHODS: ULK2 expression patterns in ovarian cancer tissues as well as benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 and Transwell assays were applied to assess the effects of ULK2 overexpression on cell proliferation, migration and invasion, respectively. RNA sequencing was performed to explore potential mechanisms of action of ULK2 beyond its classical autophagy modulation.
RESULTS: Our experiments showed significant downregulation of ULK2 in ovarian cancer tissues. Importantly, low expression of ULK2 was markedly correlated with decreased overall survival. In vitro functional studies further demonstrated that overexpression of ULK2 significantly suppressed tumor cell proliferation, migration, and invasion. RNA sequencing analysis revealed a potential regulatory role of ULK2 in the insulin signaling pathway through upregulation of insulin-like growth factor binding protein-3 (IGFBP3) in ovarian cancer cells.
CONCLUSIONS: In summary, the collective data indicated that ULK2 acted as a tumor suppressor in ovarian cancer by upregulating the expression of IGFBP3. Our study underscores the potential utility of ULK2 as a valuable prognostic marker for ovarian cancer.
The invention provides a medicine for treating hyperlipidemia and in particular relates to a blood fat-reducing traditional Chinese medicine formula. The traditional Chinese medicine formula consists of the following raw materials in parts by weight: 100-150 parts of elaeagnus mollis leaf extract, 50-70 parts of hawthorn extract, 100-150 parts of prepared fleece flower root extract and 80-120 parts of semen cassiae extract. Various raw materials in the traditional Chinese medicine formula are formed by performing drying, crushing, ultrasonic extraction, extraction, concentration, freeze drying and grinding on the raw material medicines. The animal experiment and clinic treatment prove that the traditional Chinese medicine formula has the powerful function of reducing blood fat. The traditional Chinese medicine is a pure natural medicine and has the advantages of fast effect, high cure rate and no side effect. When a patient with hyperlipidemia takes the medicine generally, the effect is achieved within half one month, the curative effect is obvious, and the total efficiency is up to 96.5 percent. The medicine is properly taken in a strengthened mode after healing, the hyperlipidemia does not resurge after healing, and the complication caused by hyperlipidemia can be prevented.
Gastric cancer (GC), a leading cause of cancer-related mortality, remains a significant challenge despite recent therapeutic advancements. In this study, we explore the potential of targeting cell surface glucose-regulated protein 94 (GRP94) with antibodies as a novel therapeutic approach for GC. Our comprehensive analysis of GRP94 expression across various cancer types, with a specific focus on GC, revealed a substantial overexpression of GRP94, highlighting its potential as a promising target. Through in vitro and in vivo efficacy assessments, as well as toxicological analyses, we found that K101.1, a fully human monoclonal antibody designed to specifically target cell surface GRP94, effectively inhibits GC growth and angiogenesis without causing in vivo toxicity. Furthermore, our findings indicate that K101.1 promotes the internalization and concurrent downregulation of cell surface GRP94 on GC cells. In conclusion, our study suggests that cell surface GRP94 may be a potential therapeutic target in GC, and that antibody-based targeting of cell surface GRP94 may be an effective strategy for inhibiting GRP94-mediated GC growth and angiogenesis. [BMB Reports 2024; 57(4): 188-193].
BACKGROUND: Hemodialysis (HD)-related nursing research has been growing over the past 2 decades, providing critical insights into improving patient care and outcomes. This study aimed to visualize the hotspots and emerging frontiers in HD-related nursing research, offering valuable references for future studies.
METHODS: A bibliometric analysis was conducted on publications related to HD nursing research from the Web of Science Core Collection database, spanning the years 2002 to 2023, and the characteristics of literature such as authors, co-cited authors, countries, research institutions, journal distribution, keywords, and cited literature were visually analyzed using CiteSpace and VOSviewer.
RESULTS: A total of 1019 publications were included in this study. The major contributors to this field were the United States, China, and Australia. The University of Sao Paulo emerged as the most prolific institution. The principal contributors were the Nephrology Nursing Journal, followed by Journal of Renal Care and Journal of Clinical Nursing. The top 5 co-occurrence keywords included HD, quality of life, dialysis, chronic kidney disease, and end-stage renal disease. The burst detection of keywords showed that current research frontier trends were pain and validation. The top 5 largest clusters of cited references included research on systematic review research, nurse-led disease management program, family caregiver, end-stage renal disease, and self-care intervention.
CONCLUSION: This study reveals productive authors, countries and institutions, research hotspots, and trends of HD-related nursing research over the past 2 decades, offering a comprehensive overview of this field worldwide.
Mobile element insertions (MEIs) are a known cause of genetic disease but have been underexplored due to technical limitations of genetic testing methods. Various bioinformatic tools have been developed to identify MEIs in Next Generation Sequencing data. However, most tools have been developed specifically for genome sequencing (GS) data rather than exome sequencing (ES) data, which remains more widely used for routine diagnostic testing. In this study, we benchmarked six MEI detection tools (ERVcaller, MELT, Mobster, SCRAMble, TEMP2 and xTea) on ES data and on GS data from publicly available genomic samples (HG002, NA12878). For all the tools we evaluated sensitivity and precision of different filtering strategies. Results show that there were substantial differences in tool performance between ES and GS data. MELT performed best with ES data and its combination with SCRAMble increased substantially the detection rate of MEIs. By applying both tools to 10,890 ES samples from Solve-RD and 52,624 samples from Radboudumc we were able to diagnose 10 patients who had remained undiagnosed by conventional ES analysis until now. Our study shows that MELT and SCRAMble can be used reliably to identify clinically relevant MEIs in ES data. This may lead to an additional diagnosis for 1 in 3000 to 4000 patients in routine clinical ES.
A microsphere making device capable of easily adjusting sphere diameter includes a substrate, a first micro channel, a sleeve, a screw, a second micro channel, a first mix micro channel and a third micro channel. Channels are provided inside the substrate and connect the outside with a threaded hole. A cone is formed between the channel and the threaded hole. The first micro channel is a space inside a thin long tube. A first injection inlet is formed at a head terminal of the thin long tube and a thin tube outlet is formed at the tail terminal. The sleeve is set between the thin long tube and the channels. The screw has a central through hole for housing the thin long tube and the screw is bolted to the threaded hole. The second micro channels have second inlets and connect the first micro channel from the left and right sides of the first micro channel. The first mix micro channel connects a confluence where the thin tube outlet and the two second micro channel meet, and has an outlet. The third micro channel connects the third micro channel and has a third inlet.
The hypothesis is that Osmotic Release Oral System (OROS) Extended Release Methylphenidate HCL (OROS MPH) is safe and effective in improving Attention Deficit Hyperactivity Disorder (ADHD) symptoms in adults with ADHD when compared to placebo as demonstrated using specific study measures. This is a double-blind (neither participant nor investigator knows the name of the assigned study drug), randomized (study drug assigned by chance), placebo-controlled study to evaluate the efficacy and safety of OROS MPH using the optimal dose for each adult patient in the study with ADHD. The primary efficacy variable in this study is the change from baseline to final evaluation using the Adult ADHD Investigator Symptom Rating Scale (AISRS) to measure patient ADHD symptoms. Participants will also be assessed for adverse events throughout the study. Patients will initiate treatment with oral OROS MPH 18 mg or matching placebo at baseline and continue morning dosing with increases every week until an optimal dose is achieved, up to the maximum of 72 mg/day of OROS MPH or matching placebo. Eligible patients will remain in the study for a maximum of 6 weeks.
The present invention relates to a method for preparing fermented ginseng berry pills. The method includes the steps of: preparing a ginseng berry extract, a Cirsium japonicum var. maackii (Maxim.) Matsum. extract, an Artemisia princeps Pamp. extract, a Chrysanthemum coronarium L. extract, an Akebia quinata (Thunb.) Decne. extract, a Plantago asiatica extract, a green tea extract, a Curcuma Longa (Turmeric) Root extract, a Malus prunifolia wild. Borkh extract, rice bran powder, soybean bran powder, arborescence powder, vitamin mixture powder, honey, biotics powder, and lactic acid bacteria; mixing and kneading the ginseng berry extract, the Cirsium japonicum var. maackii (Maxim.) Matsum. extract, the Artemisia princeps Pamp. extract, the Chrysanthemum coronarium L. extract, the Akebia quinata (Thunb.) Decne. extract, the Plantago asiatica extract, the green tea extract, the Curcuma Longa (Turmeric) Root extract, the Malus prunifolia wild. Borkh extract, the honey, the lactic acid bacteria, the rice bran powder, and the soy bran powder to prepare a first dough ingredient; fermenting the first dough ingredient mixed and kneaded in advance; sterilizing and drying the fermented first dough ingredient; grinding the first dough ingredient sterilized and dried in advance by using a grinder; mixing and kneading the ground first dough ingredient with the honey, the vitamin mixture powder, the biotics powder, and the arborescence powder to prepare a second dough ingredient; using a pill generator to prepare pills from the second dough ingredient; and drying the pills in a dryer.
Treatment of opioid use disorder (OUD) with buprenorphine improves outcomes and mortality among people with HIV (PWH). However, engagement is low and is influenced by comorbidities. We examined the impact of patterns of co-occurring pain, substance use disorders (SUDs), and mental health diagnoses on buprenorphine initiation and retention in PWH. The Veterans Aging Cohort Study contained 7,875 patients (2,702 PWH and 5,173 without HIV) with new OUD clinical encounters (2008-2017). Buprenorphine initiation and retention were derived from prescription data. We identified patterns of co-occurring diagnoses (via ICD codes) and assessed the effects of class membership on both outcomes using latent class analysis and regression analyses. The mean age of patients was 55, 98% were male, 58% Black, 8% Hispanic, and only 8% initiated buprenorphine within 12 months of OUD diagnosis. Four classes of co-occurring diagnoses were identified: "Few Co-occurring Diagnoses" (42.3%); "Multiple Pain Conditions" (21.3%); "Pain + SUD" (18.4%) and "Pain + SUD + Mental Health" (18.0%). Patients in the "Pain + SUD" class and "Pain + SUD + Mental Health" class were significantly less likely to initiate buprenorphine and had 59% and 45% lower odds, respectively, of initiating buprenorphine compared with patients in the "Few Co-occurring Diagnoses" class; this effect did not vary by HIV status. Buprenorphine retention was not significantly associated with HIV status or class membership. However, Black Veterans were less likely to initiate or be retained in buprenorphine treatment. Higher comorbidity burden was negatively associated with buprenorphine initiation but not with retention. More research is warranted to determine other factors that may influence treatment retention.
Patients with Irritable Bowel Syndrome received a low FODMAPs diet. The low FODMAPs diet was administered for 3 months.
CASE: We present the case of a 59-year-old man who had MIS L4-5 decompression. He presented the next day with intractable back and leg pain. Magnetic resonance imaging revealed ventral displacement of the cauda equina and a subdural collection on the right L3/L4 nerve roots. Revision decompression revealed occult durotomy caudal and contralateral to the index decompression.
CONCLUSION: Minimally invasive spine (MIS) surgery leverages shorter operative time and reduced postoperative pain. Yet, decreased exposure can make identification and management complications challenging. This report highlights occult durotomy and spinal subdural extra-arachnoid hygroma in patients with postoperative nerve compression after seemingly uncomplicated MISS.
FIELD: pharmacy. SUBSTANCE: invention relates to bile acid-containing aqueous solution and method for it preparing. Composition comprises water, bile acid as bile acid, salt of bile acid or bile acid conjugated with amine by amide linkage and water-soluble product of starch conversion with high molecular mass. Composition retains to be soluble in solution without precipitate formation in the range of pH values and in corresponding with a single realization composition retains in solution at all pH values that can be obtained in an aqueous system. Composition can comprise pharmaceutical compound additionally taken in pharmaceutically effective amount. Invention provides preparing clear aqueous solutions containing bile acids being without formation of precipitates in the taken range of pH values of an aqueous solution. EFFECT: improved preparing method, valuable properties of solution. 33 cl, 4 tbl, 2 dwg, 6 ex
OBJECTIVE: Modic change (MC) is defined as abnormalities observed in the intervertebral disc subchondral and adjacent vertebral endplate subchondral bone changes. Most studies on MC were reported in the lumbar spine and associated with lower back pain. However, MC has been rarely reported in the cervical spine, let alone in those who underwent cervical disc replacement (CDR). This study aimed to focus on MC in the cervical spine and reveal clinical and radiological parameters, especially heterotopic ossification (HO), for patients who underwent CDR. Furthermore, we illustrated the association between MC and HO.
METHODS: We retrospectively reviewed patients who underwent CDA from January 2008 to December 2019. The Japanese Orthopaedic Association (JOA), Neck Disability Index (NDI), and Visual Analog Scale (VAS) scores were used to evaluate the clinical outcomes. Radiological evaluations were used to conclude the cervical alignment (CL) and range of motion (ROM) of C2-7, functional spinal unit angle (FSUA), shell angle (SA), FSU height, and HO. Univariate and multivariate logistic regressions were performed to identify the risk factors for HO. The Kaplan-Meier (K-M) method was used to analyze potential risk factors, and multivariate Cox regression was used to identify independent risk factors.
RESULTS: A total of 139 patients were evaluated, with a mean follow-up time of 46.53 ± 26.60 months. Forty-nine patients were assigned to the MC group and 90 to the non-MC group. The incidence of MC was 35.3%, with type 2 being the most common. Clinical outcomes (JOA, NDI, VAS) showed no significant difference between the two groups. The differences in C2-7 ROM between the two groups were not significant, while the differences in SA ROM and FSUA ROM were significantly higher in the non-MC than in the MC group (p < 0.05). Besides, FSU height in MC group was significantly lower than that in non-MC group. Parameters concerning CL, including C2-7, FSUA, SA, were not significantly different between the two groups. The incidence of HO and high-grade HO, respectively, in the MC group was 83.7% and 30.6%, while that in the non-MC group was 53.3% and 2.2%, and such differences were significant (p < 0.05). Multivariate logistic regression analyses and Cox regression showed that MC and involved level were significantly associated with HO occurrence (p < 0.05). No implant migration and secondary surgery were observed.
CONCLUSION: MC mainly affected the incidence of HO. Preoperative MC was significantly associated with HO formation after CDR and should be identified as a potential risk factor for HO. Rigorous criteria for MC should be taken into consideration when selecting appropriate candidates for CDR.