anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Prepn. of dry emulsions based on oils or fats, emulsifiers and additives, comprises mixing pure lecithin, water and oil or fat in the ratio pure lecithin to water 1:0.5-1:3, to form an emulsifier gel. Water is then added, with stirring and this mixt. homogenised with a water-soluble organic substance that can form an amorphous matrix. The ratio organic substance to oil or fat is at least 0.7:1. Essentially all the water is then removed from the homogenised mixt. to give a dry emulsion. Dry emulsions are used in the foodstuffs industry as the basis for o/w prods. such as mayonnaise, oil enriched creams and dietetics. Improved dry emulsions are obtd. if they are prepd. as above, by first forming a hydrophilic emulsifier gel based on lecithin.
OBJECTIVE: The aim of this study was to analyze the origins of prostatic arteries (PAs) in the Korean population and compare them with those reported in the literature.
MATERIALS AND METHODS: From April 2018 to February 2024, 108 male (mean age ± standard deviation: 71.6 ± 9.7 years) with lower urinary tract symptoms (n = 102) or refractory hematuria (n = 6) underwent prostatic artery embolization (PAE). Computed tomography and angiography images were retrospectively reviewed. The branching pattern of the internal iliac artery (IIA) was classified according to the Yamaki system. The origin of the PA was categorized using the de Assis definition, and the incidence of each type was recorded. A systematic literature review was conducted and the most common types of PA were investigated.
RESULTS: PAE was successfully implemented on 211 of the 216 pelvic sidewalls. PA cannulation failed in five sidewalls due to a steno-occlusive state. The most common IIA type was type A, in which the IIA was divided into the superior gluteal artery and gluteal-pudendal trunk (77%). Of 226 PAs analyzed, including 15 in 211 sidewalls exhibiting dual PAs, the most common PA origin was the internal pudendal artery (type IV, 35%), followed by the superior vesical (type I, 25%) and obturator (type III, 21%) arteries. Anterior division of IIA (type II) was less common (10%). Type V (uncommon origins) occurred in 8% of cases, including five distal internal pudendal arteries, four quadfurcations, three inferior gluteal arteries, three trifurcations, two medial femoral circumflex arteries, and two rectal arteries. Two of the five patients with surgically or endovascularly altered anatomy were successfully treated via PAs originating from the medial femoral circumflex arteries. Globally, type I is the most common PA type.
CONCLUSION: In the Korean population, the most common IIA pattern and PA origin were types A and IV, respectively.
PURPOSE:An injection, containing ketoprofen and a polyoxyethylene hardened castor oil as active constituents, adjusted within a specific pH range, stable by sterilizing at high temperatures under high pressures and even on preservation for a long period, capable of exhibiting improved antipyretic and analgesic action and directly usable. CONSTITUTION:A ketoprofen injection obtained by incorporating 1pts.wt. ketoprofen (chemical name; 3-benzoylhydratropic acid) with 0.8-3.5pts.wt. polyoxyethylene hardened castor oil as active constituents and adjusting the pH to 6-7.5 by adding an alkali metal hydroxide or carbonate thereto. In addition to the above-mentioned essential constituents. a dissolution adjuvant, e.g., propylene glycol, or soothing agent, e.g. benzyl alcohol, are, as necessary, added and incorporated therewith. The amount of the alkali metal hydroxide to be incorporated may be normally 0.3-0.6wt% based on the total composition and the amount of the alkali metal hydroxide to be incorporated may be normally 2-3wt% based on the total composition.
Groove, or the pleasurable urge to move to music, offers unique insight into the relationship between emotion and action. The predictive coding of music model posits that groove is linked to predictions of music formed over time, with stimuli of moderate complexity rated as most pleasurable and likely to engender movement. At the same time, listeners vary in the pleasure they derive from music listening: individuals with musical anhedonia report reduced pleasure during music listening despite no impairments in music perception and no general anhedonia. Little is known about musical anhedonics' subjective experience of groove. Here we examined the relationship between groove and music reward sensitivity. Participants (n = 287) heard drum-breaks that varied in perceived complexity, and rated each for pleasure and wanting to move. Musical anhedonics (n = 13) had significantly lower ratings compared to controls (n = 13) matched on music perception abilities and general anhedonia. However, both groups demonstrated the classic inverted-U relationship between ratings of pleasure & move and stimulus complexity, with ratings peaking for intermediately complex stimuli. Across our entire sample, pleasure ratings were most strongly related with music reward sensitivity for highly complex stimuli (i.e., there was an interaction between music reward sensitivity and stimulus complexity). Finally, the sensorimotor subscale of music reward was uniquely associated with move, but not pleasure, ratings above and beyond the five other dimensions of musical reward. Results highlight the multidimensional nature of reward sensitivity and suggest that pleasure and wanting to move are driven by overlapping but separable mechanisms.
The invention relates to fat emulsions, particularly to a use of high-concentrationglycerol in freeze-thaw resistant emulsions and a free-thaw resistant emulsion thereof. The said high-concentrationglycerol is the glycerol that is greater than or equal to 3 w/v % in the emulsion composition. The maximum percentage of the glycerol in the emulsion is 50 w/v %. When the percentage of the oil in the emulsion is 2%-30 w/v %, the glycerol is more than or equal to 1/3 of the oil in the emulsion. The invention comprises adrug-contained emulsion through including drugs. Compared with prior arts, the invention provides a freeze-thaw resistant emulsion which tolerates the low-temperature freeze-thaw experiments, avoiding the pharmaceutical stability issues due to the temperature changes during the emulsion transport, storage and utilization, ensuring medicine quality, meanwhile it drastically reduces the requirements of the transport and storage conditions as well as the medicine costs.
PURPOSE:To provide a simulation method and device for the in vivo diffusion of medicines which are capable of exactly analyzing the in vivo diffusion phenomenon of medicines. CONSTITUTION:The basic parameters and coefficients, etc., required in a finite element analysis are experimentally determined without using a finite element method. The shape modeling of viable tissue to be a simulation object is performed. A finite element program is executed, the simultaneous equations on the material incoming and outgoing for each element is solved based on this set input condition and the density of the medicines components in each element is calculated. The diffusion characteristic on an experiment and the arithmetic result by the finite element analysis are compared, and when the difference of the both of them is a prescribed value or more, the diffusion characteristic coefficient on the finite element analysis is corrected. When the deviation of a reference diffusion characteristic and an arithmetic diffusion characteristic becomes minimum, the diffusion characteristic coefficient used in the finite element analysis at the time becomes an optimum diffusion characteristic coefficient. By using the optimum diffusion characteristic coefficient, a simulation is performed and the arithmetic diffusion characteristic is outputted in various kinds of modes.
The invention discloses a recombinant virus. A vesicular stomatitis virus serves as a carrier, and an encoded antibody CVB3 structural protein VP1 gene is inserted between glycoprotein G and polymerase protein L of the vesicular stomatitis virus. The invention also provides a preparation method of the recombinant virus. According to the method, the recombinant virus is obtained by means of transfecting BHK21 cells via five plasmids: pP, pL, pXN2-VP1, pVSVG and pN. The invention also provides a vaccine which contains an effective dose of vaccine contains. A person can be vaccinated with the vaccine in a mucosa part by means of nasally dripping or orally taking, or through genital tracts, and the like. The technical problems is as follows: the conventional vaccine in the prior art can not effectively induce high-strength mucosa immune response, and the antibody can not effectively stay at a local mucosa part and consequently is insufficiently taken by APCs (Antigen Presenting Cells) are solved. The recombinant virus is capable of effectively enhancing CVB3 specific serum and local mucosa part antibody response, and remarkably strengthening the killing capability to local specific CD8T cells of whole-body and intestinal mucosa.
Patients with metastatic breast cancer who initiated lapatanib between January 1, 2007 and December 31, 2007. Follow-up time for this group will continue until June 30, 2008 to allow these patients to have at least six months of follow-up time prior to the label change.
A lactate salt of l-glaucine, d,l-glaucine or their mixture is prepared by reacting isolated l-glaucine, or d,l-glaucine of an equal or excessive amount with a compd. selected from isolated salt-formed l-glaucine, d,l-glaucine, or their mixture.  The reaction is easily conducted at the ambient or boiling temp. of glaucine in the presence of inert organic solvents, such as acetone, ethanol, chloroform, methanol, diethylether, or ethyl acetate.  The produced crystals are filtered, recovered, recrystallized, and washed successively.  The lactate salt is used effectively as an analgesic and a cough remedy.
Methadone is a strong opioid that is μ-opioid receptor agonist like other opioids; however, it is additionally a N-methyl-D- aspartate antagonist with serotonin and norepinephrine reuptake inhibition; these attributes enable its efficacy in neuropathic pain and may prevent opioid tolerance over time. It is commonly used to treat opioid use disorder, as well as to treat severe pain. This medication is taken orally every 8 hours when used to treat pain. It has not been studied to treat chemotherapy-induced peripheral neuropathy.
This study focuses on the use of a neural mass model to investigate potential relationships between functional connectivity and seizure frequency in epilepsy. We fitted a three-layer neural mass model of a cortical column to intracranial EEG (iEEG) data from a Tetanus Toxin rat model of epilepsy, which also included responses to periodic electrical stimulation. Our results show that some of the connectivity weights between different neural populations correlate significantly with the number of seizures each day, offering valuable insights into the dynamics of neural circuits during epileptogenesis. We also simulated single-pulse electrical stimulation of the neuronal populations to observe their responses after the connectivity weights were optimized to fit background (non-seizure) EEG data. The recovery time, defined as the time from stimulation until the membrane potential returns to baseline, was measured as a representation of the critical slowing down phenomenon observed in nonlinear systems operating near a bifurcation boundary. The results revealed that recovery times in the responses of the computational model fitted to the EEG data were longer during 5 min periods preceding seizures compared to 1 hr before seizures in four out of six rats. Analysis of the iEEG recorded in response to electrical stimulation revealed results similar to the computational model in four out of six rats. This study supports the potential use of this computational model as a model-based biomarker for seizure prediction when direct electrical stimulation to the brain is not feasible.
Standard oral phosphate supplementation as per NHS Greater Glasgow and Clyde Guidelines. An oral solution containing potassium acid phosphate (1 mmol/mL) will be administered at a dosage of 0.5 mM/kg body weight twice daily. Dosages will be rounded to the nearest 0.1 mM/kg. Standard therapy will continue until the participant has received treatment for 14 consecutive days.
INTRODUCTION: Prescribed medicinal cannabis (MC) is an increasingly common prescription in Australia for treating pain, anxiety, and sleep disorders. Prescribed MC products generally contain tetrahydrocannabinol (THC) and/or cannabidiol (CBD) in a variety of dose levels and forms. It is unclear whether THC and CBD products are used by patients with different characteristics and for different conditions.
OBJECTIVES: To examine consumer experiences of using THC- and CBD-containing prescribed MC products to better understand how they are being used within the Australian context.
METHODS: We utilised data collected from an online anonymous cross-sectional survey of individuals (CAMS-20 survey), consisting of Australian residents using cannabis for therapeutic reasons. We focused on a subgroup of participants (N = 546) receiving prescribed MC products. We utilised linear, logistic, and multinomial regression modelling to analyse responses to survey questions based on the cannabinoid profile of the prescribed product.
RESULTS: Participants prescribed THC-dominant MC products were statistically more likely to be younger, male, and to prefer inhaled routes of administration than participants using CBD-dominant products who were older, female, and preferred oral routes of administration. Pain and mental health were the most common reasons for all types of prescribed MC, but were more likely to be treated with THC than CBD despite the significantly higher risk of mild to severe drowsiness, dry mouth and eye irritation. Consumer reported effectiveness of prescribed MC was very positive, particularly for THC-containing products. Consumers on opioids and antipsychotics were statistically more likely to be prescribed THC-containing products than products containing CBD only, despite the greater risk of impairment.
CONCLUSIONS: This Australia-wide study found clear differences in consumer-reported experiences of prescribed THC- and CBD-containing products. Current prescriptions of these products do not always align with relevant clinical guidance. Educating prescribers around cannabinoid products is essential to ensure optimal prescribing practices and to prevent avoidable drug side effects and interactions.
Participants will be prescribed an exercise plan by a physical therapist as normally would occur as part of standards of care outside the context of a research study. In-person assessments and at-home exercise suggestions will be decided by the physical therapist. Duration of PT appointments is typically 45 minutes long two times per week and are supplemented by PT recommended self-paced at-home exercises.
A coating apparatus includes a rotary cup for forming beads and projecting them radially outwardly, and one or more collection basins surrounding the bead forming cup. The cup is adjustably rotatable about its central axis, and the collection basins are independently rotatable and positioned to collect the beads projected from the cup. The coating apparatus further includes an elevation adjustment system for axially adjusting the alignment of the cup with respect to the selected collection basins. The rotational speeds of the cup and the collection basins are selected so as to minimize the impact of the beads against a gelling solution in the collection basins. In use, a supply mixture is introduced into a mixing chamber of the cup. As the cup spins, the coated particles are propelled upwardly by the centrifugal force from the mixing chamber along the inner surface of the cup, and are projected radially outwardly, as beads, into the gelling solution in one of the selected basins. Since the cup and the basin are simultaneously rotated, the impact of the beads against the capture solution is significantly reduced.
Patients randomized to outpatient cervix priming will have the insertion of the catheter in the same conditions defined by the Department protocol for inpatient cervix priming. They will be discharged after a reassuring cardiotocogram following the introduction of the Foley catheter. When discharged, the patients will be instructed to apply manual traction to the catheter every 6 hours and they will be given a written document with all the information that should bring them back to hospital.
PURPOSE:The titled composition, containing a water-soluble compound derived from chitin or chitosan and cationic surfactant and capable of imparting moist and dry feeling to the hair. CONSTITUTION:A hair cosmetic composition containing (A) a water-soluble compound derived from chitin or chitosan, e.g. hydrolyzed water-soluble oligomer with reduced molecular weight, derivative obtained by introducing hydrophilic groups and solubilized in water, partially deacetylated water-soluble chitin, etc., and (B) a surfactant, preferably quaternary ammonium salt, e.g. stearyltrimethylammonium chloride, amino acid based cationic surfactant, e.g. mono-N-long chain basic amino acid lower alkyl ester salt. The amounts of the ingredients are respectively 0.1-10wt%, preferably 0.5-5wt% based on the total amount of the composition and the weight ratio of the contained ingredients (A):(B) is 10:1-1:10.
Knee osteoarthritis (OA) typically presents with joint pain that is exacerbated by use and alleviated with rest. There is relatively brief, self-limited morning stiffness and absence of constitutional symptoms. Overweight and obesity are the most important modifiable risk factors. Although pharmacologic and nonpharmacologic interventions are generally effective at alleviating pain and improving physical function, they do not fundamentally reverse the pathologic and radiographic process of knee OA. As the severity of disease increases, the magnitude of pain and functional impairment intensifies. Surgical intervention should be pursued to relieve pain and restore functionality only when nonpharmacologic approaches and pharmacologic agents fail to control pain.
Rationale: Individuals with chronic obstructive pulmonary disease (COPD) have airflow obstruction and maldistribution of ventilation. For those living at high altitude, any gas exchange abnormality is compounded by reduced partial pressures of inspired oxygen. Objectives: Does residence at higher altitude exposure affect COPD outcomes, including lung function, imaging characteristics, symptoms, health status, functional exercise capacity, exacerbations, and mortality? Methods: From the SPIROMICS (Subpopulation and Intermediate Outcome Measures in COPD Study) cohort, we identified individuals with COPD living below 1,000 ft (305 m) elevation (n = 1,367) versus above 4,000 ft (1,219 m) elevation (n = 288). Multivariable regression models were used to evaluate associations of exposure to high altitude with COPD-related outcomes. Measurements and Main Results: Living at higher altitude was associated with reduced functional exercise capacity as defined by 6-minute-walk distance (-32.3 m [95% confidence interval, -49.8 to -14.8 m]). There were no differences in patient-reported outcomes as defined by symptoms (COPD Assessment Test and modified Medical Research Council dyspnea scale), or health status (St. George's Respiratory Questionnaire). Higher altitude was not associated with a different rate of FEV1 decline. Higher altitude was associated with lower odds of severe exacerbations (incidence rate ratio, 0.65 [95% confidence interval, 0.46 to 0.90]). There were no differences in small airway disease, air trapping, or emphysema. In longitudinal analyses, higher altitude was associated with increased mortality (hazard ratio, 1.25 [95% confidence interval, 1.0 to 1.55]); however, this association was no longer significant when accounting for air pollution. Conclusions: Long-term altitude exposure is associated with reduced functional exercise capacity in individuals with COPD, but this did not translate into differences in symptoms or health status. In addition, long-term high-altitude exposure did not affect progression of disease as defined by longitudinal changes in spirometry. Clinical trial registered with www.clinicaltrials.gov (NCT01969344).
Compounds of penicillin with urea and creatine are manufactured by reacting penicillin or a salt thereof (e.g. the sodium, calcium or ammonium salt) with urea or creatine or a salt thereof in a common solvent, and, if desired, separating the resulting compound in solid form.  In examples: (1) urea is added to a solution of penicillin in absolute methyl alcohol, which is then concentrated and penicillin urea is precipitated by adding chloroform; (2) urea citrate is added to an aqueous solution of sodium penicillin, and penicillin urea citrate is isolated by lyophilization; (3) creatine adenylate is added to an aqueous solution of sodium penicillin to produce a solution of creatine penicillin and sodium adenylate. p   The Specification as open to inspection under Sect. 91 comprises also the production of compounds of penicillin with other derivatives of urea, e.g. alkyl and acyl (especially higher aliphatic acyl) ureas and cyclic urea derivatives (examples of all of which are specified), phenylurea, thiourea and guanidine. Reference is also made to the reaction of urea derivatives with esters of penicillin.  In an additional examples, "imidazole caproic acid" of the formula <FORM:0661358/IV (b)/1> is added to a solution of sodium penicillin in hot absolute methyl alcohol and the solution is evaporated to dryness in vacuo.  This subject-matter does not appear in the Specification as accepted.
The study population will consist of fourth-year students (n=72) of Fenerbahçe University Faculty of Health Sciences, Department of Nursing, Turkish Nursing Program. Sampling calculation and sample selection will not be made in the study, aiming to reach the entire population.
The objective of this study is to compare the value of the circular region-of-interest (ROI) and whole-liver histogram-based analysis on gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced T1 map for predicting postoperative liver failure. Forty patients who underwent partial hepatectomy for focal liver lesions were retrospectively analyzed. All subjects underwent 1.5T Gd-EOB-DTPA-enhanced MRI including pre-contrast and hepatobiliary-phase T1 mapping. Patients were divided into two groups with (16 patients) and without (24 patients) postoperative liver failure according to the criteria established by the International Study Group for Liver Surgery (ISGLS). T1 values before enhancement (T1pre) and in the hepatobiliary phase (T1HBP) were measured by outlining a circular ROI on the axial T1 maps. The reduction rate of T1 relaxation time (rrT1) = (T1 pre - T1HBP) / T1 pre. The whole-liver histogram analysis was performed using the prototype MR Multiparametric Analysis software (Siemens Healthcare, Erlangen, Germany). Differences of the circular ROI-based mean values and the histogram parameters between the two groups were compared. The receiver operating characteristic curve (ROC) was plotted. The circular ROI-based mean values and the histogram parameters for predicting PHLF was assessed by the area under the curve (AUC).
Four 28-days cycles of oral Lenalidomide (20 mg / d for 21 days) and Rituximab 375mg/m2 on day 1 and day 21. After this induction phase, patients achieving at least stable disease were given lenalidomide maintenance therapy (20 mg for 21 days) until progression.
Apatinib (500 mg qd p.o.) plus POF until disease progression or intolerable toxicity or refused by the patients.
BrainMaster Discovery 24E (BrainMaster Technologies, Inc.) combined with Neuroguide software (Applied Neuroscience, Inc.) to conduct both LoRETA Z-score NF. A total treatment dosage of 600 minutes is needed.