anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain an active oxygen suppressing agent safely applicable to the skin and exhibiting active oxygen suppressing action by using conchiolin which is a kind of scleroproteins existing in shells and pearls as an active component. CONSTITUTION:For example, shells of pearl oyster, native mussel or freshwater mussel are crushed, treated with dilute hydrochloric acid, etc., to remove calcium component and subjected to a solid-liquid separation process such as centrifugal separation, filtration and decantation to collect the insoluble component. The collected material is added with refined water, thoroughly stirred and the insoluble material is collected by centrifugal separation, filtration, etc., to obtain conchiolin. The conchiolin may be hydrolyzed with water. The conchiolin or its hydrolyzate obtained by this process is used as an active component for the objective active oxygen suppressing agent. The agent is used in the form of lotion, cream, milky lotion, pack, etc. Conchiolin has remarkable effect to inhibit the formation of active oxygen and is effective for preventing chapped skin and keeping the gloss of the skin.
Participants receive RR anti-polytobacco MMS messages TIW and a check-in text message QW for a total of 6 weeks. Participants also receive smoking cessation resources via email during follow up.
Participants randomized to the cooking/dietary education intervention arm will receive 12 weeks of group-based, cooking/dietary education instruction, following a 12-week standard behavioral weight loss program. This group-based instruction will occur twice per week and classes will be 60 minutes in duration. Classes will focus on providing basic nutrition knowledge and culinary skills, and will include cooking demonstrations.
<P>PROBLEM TO BE SOLVED: To provide a fiber or a textile product composed mainly of a medicinal herb, mixed with mineral powder as necessary, and developing a composite effect by mixing two or more kinds of the components.  <P>SOLUTION: The textile product is composed of two or more kinds of powder comprising dried and pulverized medicinal herbs 2A, 2B and mineral powder 2H. The powder is applied to the surface of a yarn 3 with a binder 4 composed of rubber/synthetic resin/adhesive, or the like, or the powder is kneaded in a yarn and spun to form fibers 1a, 1b containing the medicinal herbs. As an alternative, dried and pulverized medicinal herb and a soaked paper sheet or its yarn is woven or knit to form a cloth containing the medicinal herb. The textile product is composed of two or more kinds of powder comprising medicinal herbs and powdery minerals.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
BACKGROUND: Surgery is widely regarded as a pivotal therapeutic approach for treating oesophageal cancer, and clinical observations have revealed that many oesophageal cancer patients also present with concomitant hyperlipidaemia. It is surprising that few studies have been performed to determine how blood lipid levels are affected by oesophageal cancer resection. This research was designed to assess the influence of oesophageal cancer resection on lipid profiles among individuals diagnosed with both oesophageal cancer and hyperlipidaemia.
METHODS: A retrospective analysis was carried out on 110 patients with hyperlipidaemia and oesophageal cancer who had undergone oesophagectomy at the 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army. Preoperative and postoperative serological data were collected at seven-, thirty-, sixty-day-, and one-year-long intervals. Changes in lipid levels were compared, the remission of various types of hyperlipidaemia was statistically assessed, and Pearson correlation was used to analyse the association between lipid changes and preoperative body weight. The research sought to assess the reduction in body weight and the proportion of body weight lost one year following surgery.
RESULTS: Noteworthy decreases were observed in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels, with TC decreasing from 6.20 mmol/L to 5.20 mmol/L, TG decreasing from 1.40 mmol/L to 1.20 mmol/L, and LDL decreasing from 4.50 mmol/L to 3.30 mmol/L. Conversely, there was a notable increase in high-density lipoprotein (HDL) levels, which increased from 1.20 mmol/L to 1.40 mmol/L (P < 0.05) compared to the preoperative levels. Notably, the remission rates for mixed hyperlipidaemia (60.9%) and high cholesterol (60.0%) were considerably greater than those for high triglycerides (16.2%). Alterations in TC at one year postoperatively correlated with preoperative weight and weight loss (r = 0.315, -0.216); changes in TG correlated with preoperative weight, percentage of total weight loss (TWL%), and weight reduction (r = -0.295, -0.246, 0.320); and changes in LDL correlated with preoperative weight, TWL%, and weight loss (r = 0.251, 0.186, and -0.207). Changes in non-high-density lipoprotein(non-HDL) were linked to preoperative weight (r = 0.300), and changes in TG/HDL were correlated with preoperative weight and TWL% (r = -0.424, -0.251).
CONCLUSIONS: Oesophagectomy significantly improved lipid profiles in oesophageal cancer patients, potentially leading to a reduction in overall cardiovascular risk.
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention proposes to use podophyllotoxin-β-D-glucopyranoside or 4'-demethylpodophyllotoxin-β-D-glucopyranoside acetals of the general formula (I)   where R means OH or OCH 3  and R' means alkyl, aryl or heterocyclic residue. Compounds are used for treatment and prophylaxis of amyloidosis states. Invention proposes method of treatment also. New agent and method of treatment suppress amyloid formation, do not cause severe adverse effects and suppress mutogen-induced proliferation of lymphocytes and synthesis of immunoglobulins. EFFECT: new agents indicated above, enhanced effectiveness. 8 cl, 1 tbl
<P>PROBLEM TO BE SOLVED: To obtain a ceramide synthesis promoter comprising one or more kinds selected from extracts of Oryza sativa L., Pueraria lobata ohwii, Prunus armeniaca L. var. ansu Maximowicz, Lonicera japonica Thunberg, Saxifraga stolonifera, Rubus suavissimus Shugan Lee, Apocynum venetum L., Crataegus cuneata, Rosa roxburghii Traff. f. normalis Rehd. et Wils, Acanthopanax senticosus Harms, Zizyphus jujuba var. inermis Rehd, Perilla frutescens crispa, Coptis japonica, Asarum sieboldii, Scutellaria baicalensis Georgi, Phellodendron amurense, Morus alba, Paeonia suffruticosa Andrews Paeonia, Paeonia lactiflora Pallas, Citrus unshiu Mercov, Sapindus mukorossi Gaertn, Syzygium aromaticum, Lilium candidum, Glycine max Merrill and Tremella fuciformis B., and a composition that comprises the ceramide synthesis promoter and has preventing or ameliorating effect on chapped skin and dry skin.  <P>SOLUTION: The substance comprising one or more kinds selected from extracts of Oryza sativa L., Pueraria lobata ohwii, Prunus armeniaca L. var. ansu Maximowicz, Lonicera japonica Thunberg, Saxifraga stolonifera, Rubus suavissimus Shugan Lee, Apocynum venetum L., Crataegus cuneata, Rosa roxburghii Traff. f. normalis Rehd. et Wils, Acanthopanax senticosus Harms, Zizyphus jujuba var. inermis Rehd, Perilla frutescens crispa, Coptis japonica, Asarum sieboldii, Scutellaria baicalensis Georgi, Phellodendron amurense, Morus alba, Paeonia suffruticosa Andrews Paeonia, Paeonia lactiflora Pallas, Citrus unshiu Mercov, Sapindus mukorossi Gaertn, Syzygium aromaticum, Lilium candidum, Glycine max Merrill and Tremella fuciformis B., has excellent promoting effect on ceramide synthesis. The composition comprising their extracts is safe and has excellent ameliorating effect on chapped skin and dry skin.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The protocol comprises of 60 consecutive Sham sessions, 5 sessions per week within a three months' period. Then there will be a maintenance period for 6 months in which the participants will receive Shan sessions twice a week.
Trelagliptin 100 mg tablet, orally, once weekly for up to 36 months. Participants received interventions as part of routine medical care.
This research delves into the consequences of consistent pinprick stimulation on preterm offspring to ascertain its long-term implications for pain sensitivity. The primary objective of this protocol was to investigate the impact of neonatal pinprick stimuli on the pain threshold in the later stages of life using a preterm rat model. By establishing this model, we aim to advance the research on understanding and managing early postnatal pain associated with prematurity. The findings of this study indicate that while the baseline thresholds to mechanical stimuli remained unaffected, there was a notable increase in mechanical hypersensitivity following complete Freund's adjuvant (CFA) injection in adult rats. Interestingly, compared with male rats, female rats demonstrated heightened inflammatory hypersensitivity. Notably, maternal behavior, the weight of the litters, and the growth trajectory of the offspring remained unchanged by the stimulation. The manifestation of altered nociceptive responses in adulthood after neonatal painful stimuli could be indicative of changes in sensory processing and the functioning of glucocorticoid receptors. However, further research is needed to understand the underlying mechanisms involved and to develop interventions for the consequences of prematurity and neonatal pain in adults.
Control group, Rectus sheath block will be performed under sonographic guidance. Normal saline 10 ml will be injected into the right, left rectus sheath under ultrasonography guidance at the end of the operation.
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of unknown etiology characterized by infiltration of encephalitogenic cells in the central nervous system (CNS) resulting in the presence of multifocal areas of demyelination leading to neurodegeneration. The infiltrated immune cells population is composed mainly of effector CD4+ and CD8+ T lymphocytes, B cells, macrophages, and dendritic cells that secrete pro-inflammatory factors that eventually damage myelin leading to axonal damage. The most common clinical form of MS is relapsing-remitting (RR), characterized by neuroinflammatory episodes followed by partial or total recovery of neurological deficits. The first-line treatment for RRMS relapses is a high dose of glucocorticoids, especially methylprednisolone, for three to five consecutive days. Several studies have reported the beneficial effects of melatonin in the context of neuroinflammation associated with MS or experimental autoimmune encephalomyelitis (EAE), the preclinical model for MS. Therefore, the objective of this study was to evaluate the effect of the combined treatment of melatonin and methylprednisolone on the neuroinflammatory response associated with the EAE development. This study shows for the first time the protective synergistic effect of co-treatment with melatonin and methylprednisolone on reducing the severity of EAE by decreasing CD4 lymphocytes, B cells, macrophages and dendritic cells in the CNS, as well as modulating the population of infiltrated T and B cells toward regulatory phenotypes to the detriment of pro-inflammatory effector functions. In addition to the potentiation of the protective role of methylprednisolone, treatment with melatonin from the clinical onset of EAE improves the natural course of the EAE and the response to a subsequent treatment with methylprednisolone in a later relapse of the disease, pointing melatonin as potential therapeutic tool in combination with methylprednisolone for the treatment of relapses in MS.
A method, computer program product, and computing system for receiving IR-based location information and RFID-based location information for each of a plurality of RFID/IR tags. Each of the plurality of RFID/IR tags are: associated with and configured to be releasably attached to at least one medical professional within a medical facility, associated with and configured to be releasably attached to at least one medical patient within the medical facility, or associated with and configured to be attached to at least one medical device within the medical facility. Position information is generated concerning each of the RFID/IR tags within the medical facility. Time stamp information is associated with the IR-based location information and the RFID-based location information received for each of the plurality of RFID/IR tags. Time-based movement information is generated concerning each of the RFID/IR tags within the medical facility. A time/proximity based level of performance is determined between the at least one medical professional and the at least one medical patient.
From baseline to 4-month post-test, participants in the informational control arm will not have access to the Our Plan web app program. Participants will instead receive a webpage with information about HIV/STI prevention options and resources to represent the current equivalent of a standard of care for online HIV resources.
Endometrial cancer is the most common gynecological cancer in the developed world. However, the accuracy of current diagnostic methods is still unsatisfactory and time-consuming. Here, we presented an alternate approach to monitoring the progression of endometrial cancer via multiphoton microscopy imaging and analysis of collagen, which is often overlooked in current endometrial cancer diagnosis protocols but can offer a crucial signature in cancer biology. Multiphoton microscopy (MPM) based on the second-harmonic generation and two-photon excited fluorescence was introduced to visualize the microenvironment of endometrium in normal, hyperplasia without atypia, atypical hyperplasia, and endometrial cancer specimens. Furthermore, automatic image analysis based on the MPM image processing algorithm was used to quantify the differences in the collagen morphological features among them. MPM enables the visualization of the morphological details and alterations of the glands in the development process of endometrial cancer, including irregular changes in the structure of the gland, increased ratio of the gland to the interstitium, and atypical changes in the glandular epithelial cells. Moreover, the destructed basement membrane caused by gland proliferation and fusion is clearly shown in SHG images, which is a key feature for identifying endometrial cancer progression. Quantitative analysis reveals that the formation of endometrial cancer is accompanied by an increase in collagen fiber length and width, a progressive linearization and loosening of interstitial collagen, and a more random arrangement of interstitial collagen. Observation and quantitative analysis of interstitial collagen provide invaluable information in monitoring the progression of endometrial cancer. Label-free multiphoton imaging reported here has the potential to become an in situ histological tool for effective and accurate early diagnosis and detection of malignant lesions in endometrial cancer.
INTRODUCTION: Endothelial dysfunction (ED) promotes the development of atherosclerosis, and studies suggest an association with age-related neurocognitive disorders. It is currently unclear whether ED is also associated with the risk of perioperative neurocognitive disorders.
METHOD: We included 788 participants aged ≥ 65 years of the BioCog study. Patients were scheduled to undergo elective surgery with expected duration > 60 min. Blood was collected before surgery for measurement of 5 biomarkers of ED: asymmetric and symmetric dimethylarginine (ADMA; SDMA), intercellular and vascular adhesion molecule (ICAM-1, VCAM-1), and von Willebrand factor (vWF). Patients were monitored for the occurrence of postoperative delirium (POD) daily until the 7th postoperative day. 537 (68.1%) patients returned for a 3-month follow-up. Post-operative cognitive dysfunction (POCD) was defined from the change in results on a battery of 6 neuropsychological tests between baseline and 3 months, compared to the change in results of a control group during the 3-month interval. The associations of each of the 5 ED biomarkers with POD and POCD respectively were determined using multiple logistic regression analyses with adjustment for age, sex, surgery type, pre-morbid IQ, body mass index, hypertension, diabetes, HbA1C, triglyceride, total and HDL cholesterol.
RESULTS: 19.8% of 788 patients developed POD; 10.1% of 537 patients had POCD at 3 months. Concentrations of ED biomarkers were not significantly associated with a POD. A higher VCAM-1 concentration was associated with a reduced POCD risk (adjusted odds ratio 0.55; 95% CI: 0.35-0.86). No further statistically significant results were found.
CONCLUSION: Pre-operative concentrations of ED biomarkers were not associated with POD risk. We unexpectedly found higher VCAM-1 to be associated with a reduced POCD risk. Further studies are needed to evaluate these findings.
Oral Abilify (aripiprazole) is effective in the treatment of patients with BD when prescribed as an acute anti-manic agent and for the maintenance treatment of bipolar disorder. Abilify Maintena is an intramuscular (IM) depot formulation of oral aripiprazole (Abilify). Abilify Maintena appears to be as effective as standard oral Abilify and may maximize patient adherence. Recent clinical trials suggest that Abilify Maintena is effective for the treatment of patients with BD.

Customized Adherence Enhancement (CAE) is a brief behavioral intervention that improves adherence approximately 30% more than an educational control in adults with BD. The CAE program is a brief, practical intervention consisting of a series of up to four psychosocial treatment modules based upon an adult's unique adherence barriers: 1) Psychoeducation on BD Medications; 2) Communication with Providers; 3) Strategies to Enhance Medication Routines; and 4) Targeting Substance Use Problems with Modified Motivational Enhancement Therapy. Multiple studies conducted by these investigators has shown that CAE is effective in in treating poorly adherent BD adults.

In addition, studies by these investigators have shown that combining LAI + CAE dramatically improves adherence, symptoms and functional outcomes in people with schizophrenia and schizoaffective disorder. In summary, LAI can maximize medication adherence, while CAE addresses individual barriers to sustained adherence and behavioral change. Combining LAI + CAE improves adherence, symptoms and functioning in high-risk people with primary psychotic disorders. The proposed project will test the efficacy of combining Abilify Maintena with CAE to help improve outcomes in poorly adherent patients with BD. Pilot data suggest that adherence with concomitantly prescribed psychotropic drugs improves with LAI + CAE. The findings have particular relevance to BD because many BD patients are on concomitant oral psychotropic drugs in addition to antipsychotic. Thus, it is expected that combining CAE with LAI will lead to a "halo effect" in that these BD patients will engage in their own care more broadly.
The invention relates to a Schiff base supermolecule assembled nanoparticle and application thereof as a delivery carrier. The invention relates to a method for constructing a controllable drug carrier by using a Schiff base supermolecule assembly strategy based on short peptides, belonging to the technical field of biomolecule self-assembly materials. Adding micro small molecular aldehyde solution into the metastable gel of the diphenyl alanine to perform Schiff base reaction, and obtaining the nanoparticle and beaded nanofiber with inherent fluorescence. Research shows that various hydrophilic and hydrophobic molecules can be loaded into the nano particles according to the preset content, and the adsorption efficiency and the loading efficiency are high. In addition, guest molecules having different water solubilities may be co-encapsulated in the nanoparticle at a set content ratio. This method of controlled nature of Schiff base supramolecular assembly may provide more design possibilities for the preparation of intelligent drug delivery systems.
Objective. This study examines the value of ventricular repolarization using QT dynamicity for two different types of atrial fibrillation (AF) prediction.Approach. We studied the importance of QT-dynamicity (1) in the detection and (2) the onset prediction (i.e. forecasting) of paroxysmal AF episodes using gradient-boosted decision trees (GBDT), an interpretable machine learning technique. We labeled 176 paroxysmal AF onsets from 88 patients in our unselected Holter recordings database containing paroxysmal AF episodes. Raw ECG signals were delineated using a wavelet-based signal processing technique. A total of 44 ECG features related to interval and wave durations and amplitude were selected and the GBDT model was trained with a Bayesian hyperparameters selection for various windows. The dataset was split into two parts at the patient level, meaning that the recordings from each patient were only present in either the train or test set, but not both. We used 80% on the database for the training and the remaining 20% for the test of the trained model. The model was evaluated using 5-fold cross-validation.Main results.The mean age of the patients was 75.9 ± 11.9 (range 50-99), the number of episodes per patient was 2.3 ± 2.2 (range 1-11), and CHA2DS2-VASc score was 2.9 ± 1.7 (range 1-9). For the detection of AF, we obtained an area under the receiver operating curve (AUROC) of 0.99 (CI 95% 0.98-0.99) and an accuracy of 95% using a 30 s window. Features related to RR intervals were the most influential, followed by those on QT intervals. For the AF onset forecast, we obtained an AUROC of 0.739 (0.712-0.766) and an accuracy of 74% using a 120s window. R wave amplitude and QT dynamicity as assessed by Spearman's correlation of the QT-RR slope were the best predictors.Significance. The QT dynamicity can be used to accurately predict the onset of AF episodes. Ventricular repolarization, as assessed by QT dynamicity, adds information that allows for better short time prediction of AF onset, compared to relying only on RR intervals and heart rate variability. Communication between the ventricles and atria is mediated by the autonomic nervous system (ANS). The variations in intraventricular conduction and ventricular repolarization changes resulting from the influence of the ANS play a role in the initiation of AF.
The invention discloses a Chinese herb facial cleanser containing pomegranate. The Chinese herb facial cleanser contains the following ingredients in parts by weight: 15-22 parts of pomegranate juice, 5-10 parts of hyaluronic acid, 10-15 parts of polysorbate, 10-15 parts of Chinese herb extract, 2-6 parts of lavender essential oil, 12-15 parts of deep sea fish oil, 12-18 parts of a surfactant, 5-8 parts of synergist and 20-40 parts of distilled water. The preparation method of the Chinese herb facial cleanser containing pomegranate comprises the following steps: (1) preparing the pomegranate juice, (2) preparing an important extracting solution, (3) preparing the product, and the like. The preparation method of the product is simple, and is easy in operation. The product is the high-quality facial cleanser which is free from any harmful chemical substances, is mild, controls oil, moisturizes skin, is natural and has no side effect. The selected raw materials are easy to obtain and low in cost. The facial cleanser is suitable for wide promotion and application.
Patients receive oral suberoylanilide hydroxamic acid once daily on days 1-14. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
The needle-free syringe contains the nozzle, the breaking barrier at its end, the delivery appliance, and the therapeutic agent. The nozzle has the elongated tubular shape. The breaking barrier is designed as the ruptured membrane. Upon the rupture of the membrane, the nozzle canal is opened. The therapeutic agent represents the particles of the drug. The delivery of the therapeutic agent is provided by the gas rupturing the membrane and generating the supersonic flow transferring the therapeutic agent and injecting the particles through the skin of the patient.