anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Oropouche virus (OROV) is characterized as a re-emerging arbovirus of great concern for public health, being responsible for several outbreaks of acute fever identified in Latin American countries, registering more than half a million reported cases. The incidence of reports of this virus is intrinsically favored by environmental conditions, in which such characteristics are related to the increase and distribution of the vector population to areas of human traffic. Moreover, there is a problem regarding the lack of diagnosis in Brazil that aggregates the success of the etiologic agent. Thus, by means of molecular techniques, we identified 27 positive cases of the OROV circulating in border locations in western Amazon, with 44.44% (12/27) of the cohort characterized as infected individuals with reported symptoms, mainly ranging from fever, myalgia, and back pain. Among the positive samples, it was possible to obtain a total of 48.14% (13/27) samples to analyze the S and M segments of Oropouche, which showed similarities among the Brazilian sequences. Thus, it was possible to verify the circulation of the OROV in Rondonia and border areas, in which the tracking of neglected arboviruses is necessary for the genomic surveillance of emerging and re-emerging viruses.IMPORTANCEThe western Amazon region is known for outbreaks of acute febrile illnesses, to which the lack of specific diagnostics for different pathogens hinders the management of patients in healthcare units. The Oropouche virus has already been recorded in the region in the 1990s. However, this is the first study, after this record, to perform the detection of individuals with acute febrile illness using a screening test to exclude Zika, dengue, and chikungunya, confirmed by sequencing the circulation of the virus in the state of Rondonia and border areas. We emphasize the importance of including diagnostics for viruses such as Oropouche, which suffers underreporting for years and is related to seasonal periods in Western Amazon locations, a factor that has a direct influence on public health in the region. In addition, we emphasize the importance of genomic surveillance in the elucidation of outbreaks that affect the resident population of these locations.
The invention relates to an application of a plant protein zymolyte as a polypeptide surfactant, belonging to the technical field of light chemical industry. The application is that the plant protein zymolyte with the surface tension of 25 mN/m-45 mN/m when the protein mass fraction is 0.4-1% in the state of solution or suspension is used as a polypeptide surfactant, and the polypeptide surfactant can be used as an emulsifier for food seasonings, protein drinks, meat products or cosmetics. The polypeptide surfactant has a stronger emulsifying effect than the protein. The polypeptide has small molecular weight, is easy to be absorbed by skin, hair and intestinal tracts of human bodies, and has a nutritional effect; the polypeptide surfactant also has the functions of moisturizing, resisting oxidation, reducing blood pressure, reducing blood fat, resisting bacteria and the like, has extremely high safety and biocompatibility, and is a multifunctional biosurfactant. Can be used in cosmetics, medicines, foods, etc. which are directly contacted with human body.
BACKGROUND: China faces various public health emergencies, and emergency responders at the Centers for Disease Control and Prevention (CDC emergency responders) are a mainstay in responding to public health emergencies. Career resilience can help CDC emergency responders to effectively respond to and recover from public health emergencies, but there is no specific measurement instrument available. In this study, we aimed to develop and conduct an initial validation of the career resilience instrument for CDC emergency responders in China within the context of public health emergencies from a process perspective.
METHODS: Based on a survey conducted in Shanghai, interpretive phenomenological analysis (IPA), which is a qualitative research approach to describing and analyzing individual experiences, was used to analyze the interview texts to develop the initial career resilience instrument for CDC emergency responders. The initial career resilience instrument was revised through two rounds of expert consultation. Cronbach's α coefficient and exploratory factor analysis were used to test the reliability and validity of the revised career resilience instrument.
RESULTS: The initial career resilience instrument for CDC emergency responders contained three first-level measurement dimensions, 9 second-level measurement dimensions, and 52 measurement items. After expert consultation, the first-level and second-level measurement dimensions were not revised, 13 measurement items were deleted or revised, and six measurement items were added, resulting in 48 measurement items. The revised career resilience instrument was tested for good reliability and validity.
CONCLUSION: Career resilience for CDC emergency responders can be regarded as a set of protective factors and dynamic processes that can be cultivated and intervened in cognitive, affective, and behavioral dimensions to improve their ability to respond to and recover from public health emergencies.
OBJECTIVES: To determine the prevalence of hearing loss in patients with dementia, examine the use of hearing aids in those with hearing loss, and ascertain if the cause of hearing loss is central or peripheral in origin.
METHODS: A retrospective cohort study involving 143 patients with dementia which was conducted in Saudi Arabia from 2020 to 2023 in King Abdulaziz Medical City, Riyadh, Saudi Arabia, to determine hearing loss. The study included patients aged ≥60 years who had dementia, hearing loss, and neurological diseases. Those with Parkinson's disease and secondary epilepsy were excluded. Data was analyzed for its demographics, clinical features, predisposing factors, treatment, dementia duration and progression, and hearing loss outcomes. All statistical analyses were performed using IBM's SPSS software, version 29.0.0. Statistical significance was established at a p-value of ≤0.05 and a confidence interval of 95%.
RESULTS: The findings indicated that 88.8% of the 143 patients exhibited dementia, with Alzheimer's disease being the most prevalent type. Moreover, 18.2% had hearing issues, and 11.2% had other complaints. Audiometry was performed in 15.4% of the cases. Hearing loss was present in 14.7% of the patients, being primarily bilateral, ranging from mild to severe.
CONCLUSION: This study has clarified the link between hearing loss and dementia onset and has emphasized the need for early evaluation and intervention for individuals with hearing impairment.
The invention discloses a fishery immunopotentiator and application thereof in aquaculture. The invention relates to a fishery immunopotentiator, which comprises the following components in percentage by mass: 33 to 75 percent of astragalus polysaccharide; 25 to 67 percent of white atractylodes rhizome polysaccharide; the sum of the mass percentages of the components is 100 percent. The fishery immunopotentiator is a combined preparation and can play a role in enhancing immunity. The astragalus polysaccharide and the atractylodes polysaccharide adopted by the invention can improve the nonspecific immunity of the fish body, but the astragalus polysaccharide and the atractylodes polysaccharide have different action modes and different action effects, are combined and have complementary actions, and the capability of improving the nonspecific immunity of the fish body is greatly enhanced. Moreover, the fish immunopotentiator has good effect. Indoor toxicity attacking tests show that the immune protection rate reaches 58.8%, and large pond application tests show that the immune protection rate reaches 64%. In addition, the raw materials adopted by the invention are all Chinese herbal medicine extracts, so that the invention is non-toxic and pollution-free, and has no hidden danger of damaging the breeding ecological environment and drug residue of aquatic products.
BACKGROUND: Low back pain (LBP) is a common health problem in workers that contributes to work disability and reduces quality of life. However, studies examining vulnerable groups in relation to sociodemographic differences in LBP remain scarce. Therefore, the current study investigates which sociodemographic groups of workers are most affected by LBP.
METHODS: Data from the 2018 BIBB/BAuA employment survey were used (N = 16252). Age, education, occupational group, income, working hours, atypical working time, relationship status, and having children were used as sociodemographic predictors. Gender-stratified logistic regression analyses and intersectional classification tree analyses were conducted.
RESULTS: A higher prevalence of LBP was observed for women compared to men. Significant differences in LBP emerged for age, working hours, atypical working time, occupational group and education, with some gender differences in the importance of predictors: Age was a significant predictor mostly in men as compared to women, atypical working hours had a slightly greater effect in women, whereas differences in LBP according to the occupational group were more pronounced for men. Vulnerable groups were found to be women who work in occupations other than professionals or managers, work atypical hours and have an intermediate or low educational level as well as men who work as skilled agricultural workers, craft workers, machine operators, or elementary occupations and are between 35 and 64 years old.
CONCLUSIONS: Thus, workers with certain occupations and lower levels of education, middle-aged men and women with unfavourable working time characteristics are most affected by low back pain. These groups should be focused on to potentially increase healthy working life and prevent work disability.
An ink cartridge system is provided which includes a reservoir maintained at a negative pressure in communication with a printing system. As the printing system is activated, ink is expelled from the cartridge which draws ink from the reservoir by capillary action. To prevent the reverse flow of air and ink into the reservoir, a control unit is provided. The control unit includes an ink conduit communicating with a standpipe. A medial section is provided between the ink conduit and standpipe. The medial section includes an opening adapted to receive a ball within the ink conduit. The ball is freely movable within the ink conduit, but is larger than the opening. As a result, the outward flow of ink from the reservoir is allowed, while the backflow of ink and air into the reservoir is prevented by movement of the ball into the opening of the medial section.
Couples (n=51) randomly assigned to this arm will not have access to the intervention during the 8 weeks period in which the intervention group is participating in the program. and until their participation in the study is finished, i.e., they have completed all assessments. Baseline, post-test and follow-up assessments will entail filling questionnaires collecting data on (co)parental, dyadic and work-family dimensions. After follow-up, this group will be offered to participate in the intervention if they wish to and if positive outcomes are found.
The purpose of the present invention is to provide a three-pack type dialysis agent with which it is possible to set the total acetic acid ion content in a dialysis fluid at a low value and which is excellent in terms of the storage stability of glucose, etc. and can be reduced in the odor of acetic acid. Therewith, it is possible to prepare a dialysis fluid so that the bicarbonate ion concentration can be changed at will according to need, while the concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions are kept constant. The three-pack type dialysis agent comprises agent S comprising sodium chloride, agent B comprising sodium bicarbonate, and agent A containing glucose and an electrolyte ingredient which is neither sodium chloride nor sodium bicarbonate. By making the agent A contain acetic acid and an acetic acid salt and satisfy that the molar ratio of acetic acid/acetic acid salt is 1/(0.5-2), a bicarbonate dialysis fluid having a total acetic acid ion concentration of 2 mEq/L or higher but less than 6 mEq/L can be prepared. This agent A not only is excellent in terms of the stability of the ingredients including glucose but also can be reduced in the odor of acetic acid. According to the three-pack type dialysis agent, by controlling the amounts of the agents S, B, and A to be added when preparing a dialysis fluid, the bicarbonate ion concentration and/or sodium concentration in the dialysis fluid can be also changed.
The invention discloses a medicine for treating aphtha. The medicine is prepared from the following traditional Chinese medicines serving as raw materials in parts by weight: 2.7-3.3 of cortex phellodendri, 2.7-3.3 parts of bombyx batryticatus, 1.4-1.7 parts of fructus aurantii burned ash, 1.4-1.7 parts of honey-fried licorice root powder, 1.4-1.7 parts of mint powder, 1.4-1.7 parts of radix sophorae tonkinensis and 0.09-0.11 parts of borneol. A preparation method of the medicine for treating aphtha comprises the following steps: grinding the medicines into fine powder, then fully mixing, and storing for later use. According to a using method of the medicine, the mixed medicinal powder is applied to a tongue three times every day, and the aphtha can be healed in two days. The medicine disclosed by the invention has the effects of clearing away heat and toxic materials, abating fever, eliminating dampness, diminishing inflammation and relieving pain. The medicine disclosed by the invention takes effects quickly, has a good curative effect and basically has no side effects. Generally, after being taken for 2 days, the medicine has an obvious treatment effect.
Palmar hyperhidrosis (PH) is a benign sympathetic disorder that does not threaten health but affects daily activities, and may causes social withdrawal and even depression.1 An incidence of up to 1% has been reported by various series in the literature. The incidence in men and women is the same; however women are more likely to seek medical attention, which may explain the higher incidence of female patients in most surgical series \[2,3\]. Although various treatment options are available, including topical and systemic therapies, iontophoresis, regional nerve block, and botulinum toxin injection, each has its limitations 4. Video-assisted thoracoscopic sympathetic surgery is currently a worldwide accepted treatment of primary palmar hyperhidrosis (PH) 5. However, compensatory hyperhidrosis (CH) is the most common and serious side effect that occurs in 30-70% of patients after T2 or T2-3 sympathectomy 6. For that now T2 sympathetic surgeries are seldom used in PH. Procedures that involve T3 or/and T4 sympathetic ganglions are widely accepted in many centers with favourable results.5 But some patients still present with certain degrees of CH or over dry hands after operation 7, 8.

The aim of this study is to compare the two methods for the treatment of PH, in which the sympathetic chain was transected in merely one segment, on the level of either the third or the fourth ribbed, defined as T3 sympathicotomy or T4 sympathicotomy, respectively. Emphasis was placed on the evaluation of the efficacy, side effects, and patients' satisfaction rate to these two types of surgical therapy.
The immune mechanisms mediating COVID-19 vaccine attenuation of COVID-19 remain undescribed. We conducted comprehensive analyses detailing immune responses to SARS-CoV-2 virus in blood post-vaccination with ChAdOx1 nCoV-19 or a placebo. Samples from randomised placebo-controlled trials (NCT04324606 and NCT04400838) were taken at baseline, onset of COVID-19-like symptoms, and 7 days later, confirming COVID-19 using nucleic amplification test (NAAT test) via real-time PCR (RT-PCR). Serum cytokines were measured with multiplexed immunoassays. The transcriptome was analysed with long, short and small RNA sequencing. We found attenuation of RNA inflammatory signatures in ChAdOx1 nCoV-19 compared with placebo vaccinees and reduced levels of serum proteins associated with COVID-19 severity. KREMEN1, a putative alternative SARS-CoV-2 receptor, was downregulated in placebo compared with ChAdOx1 nCoV-19 vaccinees. Vaccination ameliorates reductions in cell counts across leukocyte populations and platelets noted at COVID-19 onset, without inducing potentially deleterious Th2-skewed immune responses. Multi-omics integration links a global reduction in miRNA expression at COVID-19 onset to increased pro-inflammatory responses at the mRNA level. This study reveals insights into the role of COVID-19 vaccines in mitigating disease severity by abrogating pro-inflammatory responses associated with severe COVID-19, affirming vaccine-mediated benefit in breakthrough infection, and highlighting the importance of clinically relevant endpoints in vaccine evaluation.
Herbal aloe acne removal cream and a preparation method thereof. The herbal aloe acne removal cream includes three main components: an A phase, a B phase and a C phase. The preparation method includes following steps: (1) adding the A phase into an oil pot and the B phase into a water pot, and stirring and heating the A phase and the B phase individually for constant-temperature sterilization; (2) pre-heating a homogeneity emulsification pot, sucking the A phase and the B phase into the homogeneity emulsification pot for homogeneity emulsification; (3) decreasing the temperature to cool the A phase and the B phase, adding the C phase with stirring uniformly, and continuously stirring the mixture with temperature decreasing; (4) when the mixture in the homogeneity emulsification pot is formed into a paste, releasing the vacuum and stopping stirring; (5) lifting the pot and wiping the edge of the pot with a gauze soaked in ethanol, measuring the pH value, discharging the material with a scraper plate to obtain a semi-product; and (6) weighing and marking the semi-product, aging the semi-product, performing qualification test to the semi-product, and filling and packaging a qualified product and storing the qualified product in a storeroom. The herbal aloe acne removal cream is safer due to plant preservation. By means of the extract of lotus flower, the extract of green plums, citric acid, lactic acid, glycerin and water, the herbal aloe acne removal cream is good in bacterial inhibition and sterilization on various bacteria, fungus and mildews, has effects of inhibiting and killing corynebacterium acnes and has a significant effect of removing and inhibiting acnes. By means of the cooperation of the fresh juice of aloe, nicotinamide, the lotus flower and the green plums, the purslane and cactus, the herbal aloe acne removal cream is safer and is improved by 30-60% in effects.
PCT No. PCT/SE96/01210 Sec. 371 Date Jun. 23, 1998 Sec. 102(e) Date Jun. 23, 1998 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97/12034 PCT Pub. Date Apr. 3, 1997A modified GAD especially characterized by a substantially preserved immunogenicity in connection with diabetes compared with a non-modified GAD and a reduced or non-existent effectivity in connection with a GABA-synthesis. The invention relates also to a method for manufacturing a modified GAD, a method for supplying a modified GAD, nucleotide sequence encoding the modified GAD, a vector containing the nucleic acid sequence, a host, a pharmaceutical composition comprising modified GAD and use thereof for treating and/or preventing autoimmune disorders such as IDDM.
PURPOSE:The titled water-soluble drug being easily pharmaceutically manufactured, having rapid development of medicinal effect, containing penta-N- acetylchitopentaose and/or hexa-N-acetyl-chitohexaose as an active ingredient. CONSTITUTION:An anti-infective containing penta-N-acetyl-chitopentaose and/or hexa-N-acetyl-chitohexaose obtained by becomposing natural chitin occurring in shells of crabs, etc. as an active ingredient. Chitin has improved anti-infective activity, but it is a water-insoluble high polymer substance, and has problems in pharmaceutical manufacturing of injection, etc. The active ingredient is water-soluble, and simply pharmaceutically manufactured into injection, etc., and has almost neither toxicity nor side effects. The anti-infective has improved anti-infective effects on fungi such as Candida albicans, Staphylococcus aureus, Gram-negative and Gram-positive bacteria, etc., and its effective drug amount is 10-100mg/kg.
BACKGROUND: Higher diet quality has been associated with lower risk of developing inflammatory bowel disease, but associations between diet and gastrointestinal (GI) inflammation in healthy adults prior to disease onset are understudied.
OBJECTIVES: The purpose of this project was to examine associations between reported dietary intake and markers of GI inflammation in a healthy adult human cohort.
METHODS: In a cross-sectional observational trial of 358 healthy adults, participants completed ≤3 unannounced 24-h dietary recalls using the Automated Self-Administered Dietary Assessment Tool and a Block 2014 Food Frequency Questionnaire to assess recent and habitual intake, respectively. Those who provided a stool sample were included in this analysis. Inflammation markers from stool, including calprotectin, neopterin, and myeloperoxidase, were measured by ELISA along with LPS-binding protein from plasma.
RESULTS: Recent and habitual fiber intake was negatively correlated with fecal calprotectin concentrations (n = 295, P = 0.011, 0.009). Habitual soluble fiber intake was also negatively correlated with calprotectin (P = 0.01). Recent and habitual legume and vegetable intake was negatively correlated with calprotectin (P = 0.013, 0.026, 0.01, 0.009). We observed an inverse correlation between recent Healthy Eating Index (HEI) scores and calprotectin concentrations (n = 295, P = 0.026). Dietary Inflammatory Index scores were calculated and positively correlated with neopterin for recent intake (n = 289, P = 0.015). When participants with clinically elevated calprotectin were excluded, recent and habitual fiber, legume, vegetable, and fruit intake were negatively correlated with calprotectin (n = 253, P = 0.00001, 0.0002, 0.045, 0.001, 0.009, 0.001, 0.004, 0.014). Recent total HEI score was inversely correlated with subclinical calprotectin (P = 0.003).
CONCLUSIONS: Higher diet quality may be protective against GI inflammation even in healthy adults. This trial was registered at clinicaltrials.gov as NCT02367287.
The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-Alzheimer's or an anti-Parkinson's drug in a rapid release external coat.  Memantine is used as an anti-Alzheimer's drug or an anti-Parkinson's drug.  Particular embodiments of the invention provide osmotic devices having predetermined release profiles.  One embodiment of the osmotic device includes an external coat that has been spray-coated rather than compression-coated onto the device.  The device is useful for the treatment of depression in Alzheimer's and/or Parkinson's patients.  The device and method can also be used to treat or ameliorate other symptoms associated with Alzheimer's disease, Parkinson's disease or any other neurological disorder.  Other dosage forms that provide a controlled, sustained or extended release of venlafaxine in combination with a rapid or immediate release of memantine are useful in the invention.