anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Glaucoma is the commonest cause of irreversible blindness in the world. Treatment centres around lowering intraocular pressure (IOP) and typically includes medication (least invasive), laser, to surgery (most invasive). The gold-standard glaucoma operation is the trabeculectomy. Whilst it is effective at lowering IOP, it is associated with potentially devastating complications including bleb leak, hypotonous maculopathy, blebitis and endophthalmitis. In recent years, minimally- invasive glaucoma surgery (MIGS) has become an increasingly popular option of treating mild to moderate glaucoma. It is usually performed in conjunction with cataract surgery. The iStent (Glaukos Corporation, California, USA) is one of the most commonly utilised MIGS devices in the world and one of two Therapeutic Goods Administration (TGA)- approved MIGS devices in Australia. The iStent Inject® is the second generation iStent device and Australia is one of the first countries in the world to have access to this. So far there are no published randomised controlled trials comparing the effect of cataract surgery alone to combined cataract surgery with insertion of iStent Inject®.

This study aims to recruit patients of the Glaucoma Investigative and Research Unit (GIRU) of Royal Victorian Eye and Ear Hospital (RVEEH) with mild to moderate glaucoma who are due to undergo cataract surgery and randomise each to either cataract surgery or combined cataract surgery with iStent Inject® insertion. Only patients who meet the inclusion criteria and none of the exclusion criteria will be recruited. The outcomes measures of the study will be a comparison of: 1) extent of IOP reduction; 2) reduction in number of topical glaucoma medications; 3) patient treatment satisfaction - between the two treatment groups.
Introduction: Mexico is one of the countries with the highest prevalence of childhood obesity worldwide. The increase of addictive behaviors at an early age is a possible cause of its development. The Yale Food Addiction Scale for Children (YFAS-C) allows identifying children with food addictive behaviors. Objective: to validate the YFAS-C scale in Spanish in a population sample of Mexican children and adolescents. Material and methods: an exploratory and confirmatory factor analysis was performed. The study sample consisted of 448 children from seven to 14 years of age. The first stage involved translation into Spanish; a second stage involved the solution of questions with discrepancies; then, a reverse translation into the original language and a review by experts on the subject of eating disorders in pediatric population were performed; and in the last stage, a pilot test in order to culturally adapt the instrument and the evaluation of the psychometric properties was carried out. Results: using the principal component extraction method, four components were identified that explained 47.1 % of the sample variance. In the confirmatory factor analysis, it was found that the goodness-of-fit indices met the required values (CFI = 0.906: GFI = 0.932; AGFI = 0.915, SRMS = 0.007 and RMSEA = 0.043). Conclusions: a validated Spanish version of the YFAS-C scale was obtained for Mexican children and adolescents to assess food addiction.
Participants assigned to the active treatment arm are trained to use the mood tracker app and instructed to complete multiple self-ratings each week. Each the participant receives a support call each week for 6 weeks to engage the participant in the study and to address any problems the participant may have in completing self ratings. After 6 weeks of self-ratings, the participant complete the 6 week outcome. The participant is encouraged to continue completing the self-ratings, but does not receive any more support calls. After 6 more weeks, the 12 week outcome is assessed the participant's involvement with the study ends.
Module (A) for suppressing the activity of leukocytes, comprising: (a) a carrier; and (b) a ligand bound to the carrier that can interact with a receptor on leukocytes, is new. ACTIVITY : Immunosuppressive; Antibacterial. No biological data given. MECHANISM OF ACTION : Leukocyte Inhibitor; Apoptotic. When leukocytes are contacted with (A), their secretion of cytokines, enzyme and/or oxygen free radicals is suppressed, resulting in reduced binding affinity for epithelial cells. Where the Fas/FasL system is targeted, apoptosis is induced.
Stroke is a leading cause of long-term disability, and most stroke survivors have chronic upper limb dysfunction, which affects participation in activities of daily living. In addition to conventional rehabilitation training, robot-assisted training has been advocated as a contemporary approach of hand function training. Robotic devices can be categorized into exoskeleton and end-effector types based on their mechanical design. However, previous studies did not reach an agreement on the effectiveness of two types of robot-assisted training. The study firstly proposes a hybrid robot-assisted training program, which combines two types of robotic systems, to enhance the effectiveness of robot-assisted training and provide a new approach for motor training of upper limb in stroke patients. Secondly, the relative effects of the two types of robot-assisted training will be compared. The purpose of this study is to examine the immediate and long-term effects of hybrid robot-assisted training , exoskeleton robot-assisted training , end-effector robot-assisted training , and conventional training on stroke patients' motor performance, daily life functions, quality of life, and self-efficacy. The study will recruit stroke patients and randomly assign them to the hybrid robot-assisted training, exoskeleton robot-assisted training, end-effector robot-assisted training, and conventional training groups. Each participant will receive training 3 sessions a week for 6 consecutive weeks. Participants will be assessed at baseline, after the intervention, and at 3-month follow-up. Repeated measures of analysis of variance will be used to evaluate the changes within each intervention group at three evaluation times and to compare the differences between the four intervention groups. In order to understand the motor learning effects after receiving different interventions, the investigator use kinematic analysis to investigate the movement control mechanism of upper limb movements. The findings of this study will build the evidence-based foundation for bridging the gap between basic science and clinical application.
FIELD: pharmaceutical industry, antibiotics. SUBSTANCE: invention relates to a technology of preparing erythromycin phosphate that is a water-soluble form of erythromycin. Method involves the suspension of erythromycin base in water, suspension acidification at temperature from 4 C to 7 C with ortho-phosphoric acid solution in mass part 5% up to pH value of obtained solution from 6.4 to 6.6. Then method involves sterile filtration and lyophilic drying by freezing an erythromycin phosphate solution at temperature from 30 C to 35 C and drying under deep vacuum by step-by-step increase of temperature of a heat carrier from 20 C to +60 C. The drying is performed at the heating rate preferably 14 C/h, not above. The novel method provides the quality enhancement of erythromycin phosphate by an index "the content of anhydroerythromycine" 1.5%. EFFECT: improved method of preparing, enhanced quality. 2 cl, 1 ex
BACKGROUND: Overlapping clinical manifestations of irritable bowel syndrome (IBS) and IBS-like symptoms in patients with inflammatory bowel disease (IBD-IBS) present challenges in diagnosis and management. Both conditions are associated with alterations in metabolites, but few studies have described the lipid profiles. Our aim was to pinpoint specific lipids that contribute to the pathogenesis of IBS and IBD-IBS by analyzing multiple biologic samples.
METHODS: Diarrhea-predominant IBS (IBS-D) patients (n = 39), ulcerative colitis in remission with IBS-like symptoms patients (UCR-IBS) (n = 21), and healthy volunteers (n = 35) were recruited. IBS-D patients meet the Rome IV diagnostic criteria, and UCR-IBS patients matched mayo scores ≤ two points and Rome IV diagnostic criteria. Serum, feces, and mucosa were collected for further analysis. Lipid extraction was carried out by ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS).
RESULTS: Lipidomics of mucosa and serum samples significantly differed among the three groups. Feces showed the most altered lipid species, and the enrichment analysis of 347 differentially abundant metabolites via KEGG pathway analysis revealed that alpha-linolenic acid metabolism was significantly altered in the two groups (P < 0.01). The ratio of omega-6/omega-3 fatty acid were imbalance in serum samples.
CONCLUSIONS: This study revealed a comprehensive lipid composition pattern between IBS-D patients and UCR-IBS patients. We found several distinctive lipids involved in alpha-linolenic acid metabolism, reflecting an imbalance in the omega-6/omega-3 fatty acid ratio. Compared to mucosa and serum samples, fecal samples might have more advantages in lipidomics studies due to the convenience of sample collection and effectiveness in reflecting metabolic information.
PURPOSE:To obtain a foamable composition producible easily, composed of a solid alkali metal carbonate and a solid aliphatic carboxylic acid and an active component added to at least one of the above components, and disintegrable and foamable in a short time by moistening both components with a specific amount of water and mixing the moistened components with each other. CONSTITUTION:An active component (e.g. medicine, food agricultural chemical, etc.) is added to at least one of (A) a solid alkali metal carbonate and (B) a solid aliphatic carboxylic acid. The components A and B are moistened with 0.5-5%(W/W) each, preferably 1-2%(W/W) each of water, and the components are mixed together to obtain the objective foamable composition. Since the acidic component and the alkaline component are kneaded, tableted, dried and granulated after mixing, the production steps can be decreased. It has excellent tabletability and is disintegrated rapidly in water.
In accordance with the principles of the present invention, a method and system of generating food recommendations is provided. A patient drug profile is provided listing currently prescribed medications for a patient. The patient drug profile is analyzed to establish an individual's medical condition(s), or disease state profile, from National Drug Code numbers, for example, in the patient drug profile. A nutritional database is provided. The nutritional database includes foods that are beneficial and/or harmful to various disease states. Food recommendations based on the individual's medical condition(s), or disease state profile, are provided from the nutritional database. The food recommendations can include both foods to avoid and foods to consume. Additional information, such as coupons, for example, based on the food recommendations, and a product location guide based on the food recommendations can be provided. In one implementation, the method and system of generating food recommendations can be provided in a pharmacy management system within a grocery store. In another implementation, the method and system of generating food recommendations can be provided using any computing device.
Compelling evidence exists that breast milk helps protect premature infants from prematurity-specific morbidities, including feeding intolerance, late onset sepsis, and necrotizing enterocolitis. Unfortunately, mothers of VLBW infants often exhibit delayed lactogenesis stage II (when the milk "comes in") and inadequate breast milk production. Earlier initiation of breast milk expression following delivery is associated with increased lactation success. However, lack of nursing time and lack of hospital personal are significant barriers to the early initiation of milk expression in this population. The proposed study will follow a prospective cohort of racially and economically diverse mothers of premature infants for 3 weeks following delivery to test 1 primary aim and 1 secondary aim. Aim 1: will evaluate the feasibility of antenatal BM pumping education for SPs of mothers of preterm infants. Issues related to recruitment, randomization acceptance of the intervention, and refinement of the education materials and process will be scrutinized. Aim 2 will estimate variability of outcome measurements and effect sizes needed to calculate the sample size for a subsequent larger, adequately powered, randomized clinical trial. Eligible women and their SP will be randomly assigned to one of two groups. Group 1 will receive a prenatally delivered lactation educational program including video recordings, a demonstration of how the pump works and will have a breast pump available in their room. The volume of breast milk produced, timing of lactation stage II, duration of lactation and stress during initial expression will be measured. In addition, breast milk sodium levels will be analyzed on Day 1-7, Day 14 and 21.
BACKGROUND: Despite albumin-creatinine ratio (urine) testing being recommended for detection of chronic kidney disease among adults with diabetes, testing rates are suboptimal.
AIM: We implemented and evaluated a quality improvement project in an inner-city diabetes population in London, UK to assess the feasibility and acceptability of implementing novel home-based urinalysis using smartphone technology.
METHODS: After eligible patients were identified and consented, testing kits were sent to the patient's home. Test results and patient feedback were collected through the smartphone application. Focus group discussions were conducted to evaluate primary care staff perspectives on uptake and delivery of the service.
RESULTS: In total 2370 patients agreed to take part. Of these, 1244 completed the test (61% of those eligible) and of these, 465 (37%) had clinically significant albuminuria. 98% of patients found the test easy or very easy to use. Staff in primary care found the service to be beneficial for patients, and reported ease of set up and minimal administrative processes. Concerns regarding barriers among patients with lower digital literacy and non-English speakers were raised although these concerns were not substantiated.
CONCLUSION: Home-based albumin-creatinine ratio urine testing may improve the testing rates of people with diabetes at higher risk of chronic kidney disease. This is important post-pandemic, as healthcare services are trying to return to pre-pandemic levels of care. The study also found that the use of smartphone technology in an underserved (deprived) community is feasible, despite reservations about levels of digital literacy and possible language barriers. Further evaluation of effectiveness and costs is required.
In addition to the core stabilization exercises myofascial relaxation technique will be performed with roller massager (Theraband®, The Hygenic Corporation, Akron, OH.) for 3 days per week for 6 weeks.
Ultrasound is considered the first line examination in the exploration of the thyroid nodule. Echotexture analysis often identifies nodules at risk of malignancy, but does not replace or exclude an additional cytological exploration. Cytology, although effective, also has limitations, particularly when samples are vesicular and it is difficult discern between a benign or malignant state. The creation of a noninvasive method in this context could help to avoid invasive tests or "useless" surgical procedures.

Ultrasound elastography, which assesses tissue deformability, may provide valuable information concerning benign soft tissue characteristics, whereas malignant lesions are harder in consistency. Interest in this method, already proposed for other organs, has recently increased due to the emergence of specifically created software that enables objective evaluation of the hardness of the nodule during a conventional ultrasound analysis. The main hypothesis of this study is that elastography should allow better selection of candidates for thyroid surgery.
Background: Poor sleep quality is prevalent among adults with diabetes, impacting their physical, psychological, and functional well-being. Our goals were to assess the prevalence of poor sleep quality and its association with glycemic control and to identify predictors of poor sleep quality among adults with diabetes mellitus. Methods: This cross-sectional study took place at a tertiary hospital, from October 2022 to March 2023, including 192 adults with type 1 and type 2 diabetes. We collected demographic and clinical data and utilized the Pittsburgh Sleep Quality Index (PSQI) scale to evaluate sleep quality. Results: A total of 65.9% of the participants experienced poor sleep quality (PSQI score > 5), with an average global sleep quality score of 7.36 ± 3.53 for all patients. Poor sleep quality was higher among older and married patients, those with lower education levels, housewives, and those with type 2 diabetes mellitus and associated comorbidities, such as hypertension and dyslipidemia. None of these factors were significantly associated with sleep quality in a multiple linear regression analysis. The mean glycated hemoglobin was 8.68 ± 1.91% and did not correlate with the overall PSQI score and its components. Conclusions: This study revealed a notably high prevalence of poor sleep quality among Saudi adults with diabetes, potentially associated with specific sociodemographic and clinical factors. These findings emphasize the importance of integrating sleep quality education into diabetes management strategies.
Hydroxychloroquine will be administered as a once daily dose of 200 or 400 mg, based on the patient's weight. Treatment will be for 96 weeks.
PROBLEM TO BE SOLVED: To obtain a cosmetic without causing skin roughening, etc., due to the elution of an ultraviolet light absorber and contact with skin by including a resin particle of a specific constitution therein. SOLUTION: This resin particle has a core material part obtained by copolymerizing a reactive benzotriazole-based compound with an acrylic or a methacrylic monomer and having ultraviolet absorptivity and a surface layer part formed on the surface of the core material part and comprising a methacrylate-based resin. The particle can be produced by dispersing a monomer forming a resin to be the core material and toluene in an aqueous medium, carrying out a polymerizing reaction, then adding the methacrylic monomer into the aqueous medium, polymerizing the monomer and volatilizing the toluene at the time of drying. Thereby, since the resin itself forming the particle has the ultraviolet absorptivity, the elution of the ultraviolet light absorber is extremely slight. The surface of the resin is coated with the methacrylate-based resin without having a benzotriazole skeleton.  Thereby, the benzotriazole skeleton is not directly brought into contact with skin.
The group who have received a sham device along with Injection paracetamol in a dosage of 15mg/kg every 6th hourly. Break through pain with NRS\>4 will be managed with injection tramadol at 1mg/kg followed by 0.5mg/kg after 10mins in cases of persisting pain.
Participants will participate in 12-week telehealth cardiac rehabilitation. The program will follow the same core components as in-person cardiac rehabilitation, but in-person supervised exercise will not be required. The core element of telehealth cardiac rehabilitation is 12 weekly individual telehealth sessions between the patient and cardiac rehabilitation provider.
<P>PROBLEM TO BE SOLVED: To provide a method and apparatus for extracting fucoxanthin from seaweed with a remarkably good extraction ratio and recovery ratio of fucoxanthin.  <P>SOLUTION: Fucoxanthin is extracted from seaweed with a high-pressure fluid. As the high-pressure fluid, a supercritical fluid, a subcritical fluid or the like is used. As a component of the fluid, for example, carbon dioxide is used. Fucoxanthin can be also extracted with the use of a mixed fluid of such a high-pressure fluid and an auxiliary solvent. Furthermore, it is also possible to carry out a pretreatment such as solar drying, freeze drying, and enzyme treatment.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Children randomized to the Food Secure group will receive breakfast and lunch meals for eight weeks throughout the summer. Weekly meals will be delivered to each participant's home by Yumble, a company that prepares meals for children ages 3 to 12 years and ships them fresh in insulated, food safe packaging to the home. The meals have similar nutrition standards to those offered via the National School Lunch Program and include fruits, vegetables, whole grains, and lean/ vegetarian proteins. To accommodate cultural preferences or dietary constraints, Yumble offers 20 different breakfast, lunch and dinner meals each week. Families will choose their weekly menus to improve adherence. Participants who have siblings in their home will be provided a family meal kit, which provides 24 meals each week. Additional meals will help to prevent household food insecurity and ensure that the child enrolled in the study consumes the meals each week.
The control app, also called Pulse, is a web-based mobile health app designed by the study team for young women ages 18-20. Although Pulse control and Pulse treatment apps look and feel similar aesthetically, they contain different content. Pulse control app provides information on general health topics, such as the importance of sleep, healthy eating, and friendships. Users access Pulse autonomously, on their own terms, and in their own time and place. The app does not require the user to follow a specific sequence of content viewed; however, all users receive a monetary incentive after completing a baseline survey and registering with the app. Control participants also receive MMS messages related to general health for six weeks. Participants receive a baseline survey and a six-week follow-up which are conducted online via an electronic survey platform.
Epithelial ovarian cancer (EOC) is one of the leading causes of cancer-related death in women worldwide, and is characterized by a high rate of recurrence after surgery and chemotherapy. We sought to implement a circulating tumor DNA (ctDNA)-based blood test for more accurate post-operative surveillance of this disease. We analyzed 264 plasma samples collected between June 2016 and September 2021 from 63 EOC patients using tumor-guided plasma cell-free DNA analysis to detect residual disease after treatment. Assay specificity was verified using cross-patient analysis of 1,195 control samples. ctDNA was detected in 51 of 55 (93%) samples at diagnosis, and 18 of 18 (100%) samples at progression. Positive ctDNA in the last on-treatment sample was associated with rapid progression (median 1.02 versus 3.38 yr, HR = 5.63, P < 0.001) and reduced overall survival (median 2.31 versus NR yr, HR = 8.22, P < 0.001) in patients with high-grade serous cancer. In the case of 12 patients, ctDNA assays detected progression earlier than standard surveillance, with a median lead time of 5.9 mo. To approach the physical limits of ctDNA detection, five patients were analyzed using ultra-sensitive assays interrogating 479-1,856 tumor mutations, capable of tracking ctDNA fractions down to 0.0004%. Our results demonstrate that ctDNA assays achieve high sensitivity and specificity in detecting post-operative residual disease in EOC.