anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Within each participating institution, clinician clusters are randomized to 1 of 4 start date training times for the African American Communities Speak (AACS) Education Intervention. Each arm has a pre-intervention (control) period and a post-intervention (exposure) period.
Overdoses with lopinavir and ritonavir oral solution have been reported. One of these reports described fatal cardiogenic shock in a 2.1 kg infant who received a single dose of 6.5 mL of lopinavir and ritonavir oral solution (520 mg lopinavir, approximately 10-fold above the recommended lopinavir dose) nine days prior. The following events have been reported in association with unintended overdoses in preterm neonates: complete AV block, cardiomyopathy, lactic acidosis, and acute renal failure [see Warnings and Precautions (5.2)] . Healthcare professionals should be aware that lopinavir and ritonavir oral solution is highly concentrated and therefore, should pay special attention to accurate calculation of the dose of lopinavir and ritonavir, transcription of the medication order, dispensing information and dosing instructions to minimize the risk for medication errors and overdose. This is especially important for infants and young children. 

Lopinavir and ritonavir oral solution contains approximately 42% (v/v) ethanol and approximately 15% (w/v) propylene glycol. Ingestion of the product over the recommended dose by an infant or a young child could result in significant toxicity and could potentially be lethal.

  


Human experience of acute overdosage with lopinavir and ritonavir is limited. Treatment of overdose with lopinavir and ritonavir should consist of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient. There is no specific antidote for overdose with lopinavir and ritonavir. If indicated, elimination of unabsorbed drug should be achieved by gastric lavage. Administration of activated charcoal may also be used to aid in removal of unabsorbed drug. Since lopinavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the drug. However, dialysis can remove both ethanol and propylene glycol in the case of overdose with lopinavir and ritonavir oral solution.
The most important aspect of physical fitness is flexibility, which can be greatly impacted by bad posture that might occur from a sedentary lifestyle of a person and a reduction in the soft tissues' flexibility cause serious musculoskeletal injuries. Long periods of sitting in school going children can cause the hamstring muscles to shorten because they bend the knee. There are numerous methods for improving hamstring flexibility, but very few of them produce immediate results. The literature demonstrated that the two most successful stretching methods to compare were hold-relax and MET but there is paucity to determine their immediate effectiveness.

The purpose of this study will be to compare between the immediate effects of hold-relax proprioceptive neuromuscular facilitation and muscle energy technique (MET) for hamstring flexibility in school going children and to determine which strategy improves hamstring flexibility in school-aged children the fastest and with the best results. This will be the randomized clinical trial in which total time of six month will be utilized after the approval from BASR. Data will be collected from Unique Science School Al-Rehman Campus, Lahore. 106 participants will be taken with 05-12 years of age through purposive sampling technique. Participants will be divided into two equal groups. Participants in group A will be given hold-relax PNF and the group B will underwent METs (reciprocal inhibition). Hamstring ROM will be assessed through AKET. Measurements will be taken by goniometer. Wong-Baker faces pain scale (WBFPS) and Timed 'Up and Go' (TUG) test will be used to evaluate pain and functional mobility respectively. Data will be analyzed on SPSS version 25. Results after statistical analysis will show which technique is more effective and will have best outcomes
BACKGROUND: Citizenship fatigue has been identified as a negative consequence of performing organizational citizenship behaviors and has been studied due to its undesirable effects on employees and organizations. This article aims to present the results of adapting the citizenship fatigue scale to Portuguese language and to provide evidence of its validity.
METHODS: The research methodology involved multiple stages. Initially, the Citizenship Fatigue Scale was translated into Portuguese using a robust back-translation process involving three bilingual translators to ensure semantic accuracy. Subsequently, for psychometric testing, the Citizenship Fatigue Scale and Compulsory Citizenship Behavior Scale were administered to a sample of 406 employees from different economic sectors (103 male; 303 female), aged 18 to 70 years. Reliability and validity indicators were calculated from the CFA structure, employing the maximum likelihood estimation with bootstrapping. Gender invariance was examined at three different levels: [1] configural invariance [2], factor loading invariance and [3] factor loading and intercept invariance.
RESULTS: The internal consistency, of the whole scale, measured by Cronbach's alpha, was 0.94. The composite reliability value was also very satisfactory (CF = 0.94). The variance extracted from mean (AVE) value of 0.79 was higher than the required limit of 0.50, indicating an adequate fit of the model. The confirmatory analysis supported a single-factor model and showed good to very good fit indexes (CFI = 1.00; GFI = 0.99; RMSEA ≤ 0.01). The model was successfully replicated with a male and female sample.
DISCUSSION: The results confirm that the Portuguese version of the Citizenship Fatigue Scale is a reliable instrument for research with Portuguese speaking samples and international research.
INTRODUCTION: COPD is the 3rd leading cause of death worldwide, affecting an estimated 212.3 million people. More than 80% of this burden occurs in low- and middle-income countries. One of the major reasons for this growing burden, is the lack of awareness of COPD among all levels.
AREAS COVERED: In this review article, we studied the level of awareness of COPD among lay people, health care providers and policy makers in the LMICs. Search engines including Google Scholar, PubMed, and Scopus were used for relevant articles. Articles spanning from 1990 to March 2024 were screened on COPD awareness in LMICs and its treatment implications using a combination of key words.
EXPERT OPINION: We report that the overall awareness of COPD is low at all levels. There are several reasons such as poverty, illiteracy, societal beliefs, cultural beliefs, and misconceptions. This is associated with increase in suffering, deaths, and economic loss, due to poor adaption correct prescription and compliance to treatment. And very little is being done to improve the current status. COPD needs to be highlighted in the national programs in LMICs.
Objective: This study aimed to investigate the effectiveness of prophylactic photobiomodulation (PBM) in reducing postinflammatory hyperpigmentation (PIH) induced by carbon dioxide (CO2) laser resurfacing in a patient with periorbital syringomas. Background: PIH is a common condition characterized by abnormal skin pigmentation after an inflammatory process occurring in up to 20-30% of patients undergoing CO2 laser resurfacing. Methods: The patient was treated with PBM using a pulsed home-use device at 630 nm before and after CO2 laser treatment. The patient was asked to treat the right periorbital area before and after the CO2 laser treatment, which was continued once a day for 2 consecutive weeks. Results: At 12 weeks, PIH was significantly reduced on the treated side compared with the contralateral untreated side (leading to persistent erythema at 6 months). Conclusions: This is the first report of prophylactic treatment of CO2 laser-induced dyschromia using PBM.
Standard care according to the Dutch EOS guideline. Presepsin will be determined with the treating physician blinded for the test result. In the Dutch EOS guideline maternal and neonatal risk factors for EOS are categorized as red flags or minor criteria. In the presence of 1 red flag or ≥ 2 minor criteria it is advised to perform a blood culture (= sepsis evaluation) and start empirical antibiotics for EOS suspicion. Antibiotic treatment will be advised to discontinue when blood culture turns back negative, reassuring the infants clinical condition with no other indicators of possible infection (e.g. CRP).
* Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.
  * Some of these NSAID medicines are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.



*Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain. The OTC NSAID label warns that long term continuous use may increase the risk of heart attack or stroke.

This Medication Guide has been approved by the U.S. Food and Drug Administration.
This is a multicenter, single-arm, open study. Thirty patients with stage IV nsqNSCLC with BMs confirmed by histopathology or cytology and reported negative driver genes within three months were enrolled. To evaluate the safety, tolerability and efficacy of Serplulimab combined with bevacizumab and first-line chemotherapy in driver negative nsqNSCLC subjects with brain metastases.

Qualified subjects were selected and entered into the study in sequence. The trial was divided into combination chemotherapy period (C1-C4/C6) and maintenance treatment period (C5/C7-C32). In combination chemotherapy period, all subjects were treated with Serplulimab combined with bevacizumab and chemotherapy agents after entering the study, and in maintenance treatment period, Serplulimab combined with bevacizumab and pemetrexed. The efficacy was evaluated every 3 weeks (Q3W), every 2 cycles in combination chemotherapy and every 3 cycles in maintenance treatment. All subjects received treatment until subjects withdrew their informed consent, disease progression, intolerable toxicity, investigator judgment that medication must be discontinued, loss of follow-up, death, or 2 years of use of Serplulimab, whichever occurred first; At the end of treatment, patients were followed up for survival until death.
Previous studies have revealed that sarcopenia, defined as generalized loss of skeletal muscle mass, is a poor prognostic factor following surgery. However, research focusing on postoperative muscle wasting and its influence on the prognosis of resectable pancreatic cancer (PC) is limited. Investigators retrospectively reviewed 208 patients who underwent pancreatectomy for PC at the National Cheng Kung University Hospital (NCKUH) between June 2002 and April 2020. Clinical information regarding patient characteristics, pathological parameters, and biochemical features was collected from all patients using electronic medical records (EMRs) under an IRB-approved protocol (B-ER-110-420) at NCKUH. Preoperative psoas major area and the degree of muscle reduction at 3 months postoperatively were calculated using computed tomography to define sarcopenia and drastic muscle wasting. Patients were assigned to two groups based on sarcopenia or drastic muscle wasting, and compared for postoperative morbidity, disease free survival (DFS), and overall survival (OS).
Doxycycline has been used in clinical practice for early stages of Lyme disease for several decades. Thorough search of the published literature identified 31 studies in which doxycycline treatment was used for the treatment of Lyme disease. Of these 31, three randomized studies evaluating doxycycline treatment in patients with erythema migrans and associated symptoms were identified 1-3. In addition, two natural history studies of Lyme disease evaluated disease progression in patients presenting with erythema migrans and associated symptoms 4,5. Over 200 patients from Lyme-disease hyperendemic areas were enrolled in these five studies, and more than 100 received doxycycline. Evidence of efficacy was derived by comparing the doxycycline treatment in studies using doxycycline 100 mg twice daily for 20-21 days with no treatment in the natural history studies. Clinical resolution of symptoms was defined as absence of objective late manifestations of Lyme disease, specifically those related to the musculoskeletal, nervous, and cardiac systems at 6 months. In comparison to untreated patients, doxycycline-treated patients had a higher response rate at 6 months. Doxycycline-treated patients had a response rate of 75-95% compared to 56-66% in untreated patients.
PURPOSE:A substance having anti-inflammatory effect is used as an agent for removing immuno-suppressing substance useful as a preventive and remedy for infections diseases, cancers, hepatic diseases, etc. CONSTITUTION:A substance having anti-inflammatory activity (e.g. cortisone acetate, predonisolone, acetanilide, salicylic acid, mefenamic acid, indomethacin, IS substance, IAP, alpha2-macroglobulin, etc.) is used as an agent for removing immuno-suppressing substances. The body fluid of the patient of cancer, infections disease or refractory disease contains increased amount of immuno- suppressing substance, and the content of immuno-suppressing substance in serum can be lowered by administering the titled agent. It is useful as a remedy of infections diseases, refractory diseases, cancers, various hepatic diseases, renal insufficiency, gastric ulcer, etc.
The invention establishes a set of nutritional profiles in a data processing system, which are utilized to establish an optimal meal menu for a given time and location and with regard to a set of available ingredients. The invention includes a profiling routine where a set of characteristics of a particular individual is entered.  The characteristics are aggregated with data saved for other patrons. When an individual with an established profile enters a networked eatery, they initiate a menu routine by entering their identification. The routine matches the information with the aggregated data to determine a patron match, which in turn is matched with the set of characteristics to determine an optimal menu plan. The optimal menu plan is matched with the set of available ingredients to produce a menu. Selected menu items are recorded to the patron's nutritional profile which can be visually represented in any of several formats.
Contraception

Use of BANZEL may reduce the effectiveness of hormonal contraceptives containing ethinyl estradiol or norethindrone. Advise women of reproductive potential taking BANZEL who are using a contraceptive containing ethinyl estradiol and norethindrone to use an additional non-hormonal form of contraception [see Drug Interactions (7.3) and Clinical Pharmacology (12.3)].

Infertility

The effect of rufinamide on fertility in humans has not been established. Oral administration of rufinamide (20, 60, 200, and 600 mg/kg/day) to male and female rats prior to mating, during mating, and during early gestation (females only) resulted in the impairment of fertility at all dose levels tested. The no-effect dose was not established. The plasma exposure level at 20 mg/kg was approximately 0.2 times the human plasma AUC at the MRHD [see Nonclinical Toxicology (13.1)].
The present invention discloses an upper limb rehabilitation evaluation system, which includes a rehabilitation sensing unit and a rehabilitation evaluation unit. The stage has a start position and an end position. Each sensing element includes a start sensing piece set at the start position and an end sensing piece set at the end position. The rehabilitation evaluation unit has built-in rehabilitation teaching data displayed on the display module as rehabilitation teaching information. When the subject performs the upper limb movement of picking up the object from the start position to the end position, the start sensing piece and the end sensing piece generate a start signal and an end signal respectively. After the signals are collected and processed, data analysis is performed, and the corresponding electronic evaluation scale information is outputted, so that the rehabilitation movement can be sensed without sticking the sensing element on the limb during the evaluation process. Therefore, it has the following advantages: small size and easy to carry, easy to operate due to the combination of software and the universal design, and that the system can be evaluated and recorded by professional medical staff before the stroke patients can perform operation training by themselves, which greatly improves the patient's willingness to train independently and accelerates the recovery of the patient's independence in daily life.
Rice blast disease, caused by the fungal pathogen Magnaporthe oryzae, is a major threat to rice production worldwide. This study investigates the role of long non-coding RNAs (lncRNAs) in rice's response to this destructive disease, with a focus on their impacts on disease resistance and yield traits. Three specific lncRNAs coded by M. oryzae infection-responsive lncRNAs (MOIRAs), MOIRA1, MOIRA2, and MOIRA3, were identified as key regulators of rice's response to M. oryzae infection. Strikingly, when MOIRA1 and MOIRA2 were overexpressed, they exhibited a dual function: they increased rice's susceptibility to blast fungus, indicating a negative role in disease resistance, while simultaneously enhancing tiller numbers and single-plant yield, with no adverse effects on other yield-related traits. This unexpected improvement in productivity suggests the possibility of overcoming the traditional trade-off between disease resistance and crop yield. These findings provide a novel perspective on crop enhancement, offering a promising solution to global food security challenges by developing rice varieties that effectively balance disease resistance and increased productivity.
BACKGROUND: Life skills play a key role in the transition of a child with intellectual disabilities into a young adult. According to previous research, students with intellectual disabilities often lack such skills. However, most studies on this topic have been conducted on teachers or parents. Limited studies are available on adolescents with intellectual disabilities. Therefore, this study investigates how adolescents with disabilities perceive their competence in life skills post-school.
METHOD: The sample consisted of 201 adolescents with disabilities (67 % with mild intellectual disabilities and 33 % with other disabilities).
RESULTS: The results revealed that adolescents with intellectual disabilities' perception of their life skills in all areas (independent living, personal money management, community involvement and usage, leisure activities, health, and social/interpersonal relationships) was significantly lower compared to adolescents with other disabilities. In four out of the six sub-scales, female respondents reported that their competence level in life skills was lower compared to males. In addition, adolescents with disabilities in daycare centers stated that they could establish better social and personal relationships when compared to adolescents from other schools.
Mercaptopurine is hepatotoxic. There are reports of deaths attributed to hepatic necrosis associated with the administration of mercaptopurine. Hepatic injury can occur with any dosage but seems to occur with greater frequency when the recommended dosage is exceeded. In some patients, jaundice has cleared following withdrawal of mercaptopurine and reappeared with rechallenge. 

Usually, clinically detectable jaundice appears early in the course of treatment (1 to 2 months); however, jaundice has been reported as early as 1 week and as late as 8 years after the starting mercaptopurine. The hepatotoxicity has been associated in some cases with anorexia, diarrhea, jaundice and ascites. Hepatic encephalopathy has occurred. 

Monitor serum transaminase levels, alkaline phosphatase, and bilirubin levels at weekly intervals when first beginning therapy and at monthly intervals thereafter. Monitor liver tests more frequently in patients who are receiving mercaptopurine tablets with other hepatotoxic products [see Drug Interactions (7.5)] or with known pre-existing liver disease. Withhold mercaptopurine tablets at onset of hepatotoxicity.
The worldwide decline in malaria incidence is revealing the extensive burden of non-malarial febrile illness (NMFI), which remains poorly understood and difficult to diagnose. To characterize NMFI in Senegal, we collected venous blood and clinical metadata in a cross-sectional study of febrile patients and healthy controls in a low malaria burden area. Using 16S and untargeted sequencing, we detected viral, bacterial, or eukaryotic pathogens in 23% (38/163) of NMFI cases. Bacteria were the most common, with relapsing fever Borrelia and spotted fever Rickettsia found in 15.5% and 3.8% of cases, respectively. Four viral pathogens were found in a total of 7 febrile cases (3.5%). Sequencing also detected undiagnosed Plasmodium, including one putative P. ovale infection. We developed a logistic regression model that can distinguish Borrelia from NMFIs with similar presentation based on symptoms and vital signs (F1 score: 0.823). These results highlight the challenge and importance of improved diagnostics, especially for Borrelia, to support diagnosis and surveillance.
Methods and Systems for viewing, manipulating, transmitting and comparing digital image patient imaging studies. The methods and systems enable a user to take, receive, store and transmit digital imaging studies. The system allows the digital imaging studies to be stored locally and backed up at a remote server. The user is able to provide commands to provide for additional services or features to be performed on the imaging studies at the remote server and/or the local server. Users at local servers are able to grant access to selected images to third parties for collaboration. The user is able to compare a digital patient image with a digital image of an appropriate implant enabling the user to properly size, fit and locate the implant with respect to the digital image. Additionally, the system allows the user to compare digital images over time to determine implant movement with respect to its insertion, as well as changes within the bones.