anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes selective inhibitors of thrombin of the following formula (I) R 1 ,R 6 ,R 7  where values  , X are given in p. 1 of the invention claim. These compounds can be used orally also. Invention describes also a pharmaceutical composition based on compounds of the formula (II) used for inhibition of thrombin activity. EFFECT: valuable pharmacological properties of compounds. 4 cl, 7 tbl, 58 ex
The invention belongs to the technical field of biology, and discloses a hybridoma cell strain with a preservation number of CCTCC (China center for type culture collection) NO. C2022340. The invention also discloses an anti-swine S100A12 protein (calgranulin C) monoclonal antibody S100A12-F5C6 secreted by the hybridoma cell strain CCTCC NO. C2022340 and a coding gene thereof. The invention also discloses application of the S100A12-F5C6 antibody in detecting swine inflammatory diseases and application of the swine S100A12 protein in antibacterial activity. The monoclonal antibody of the swine S100A12 protein has stronger affinity and stability, can specifically bind to the swine S100A12 protein, and lays a foundation for further researching the function of the S100A12 protein and developing genetically engineered antibody medicines and novel vaccines for preventing or treating swine inflammatory diseases.
A 6-year-old intact female domestic dwarf rabbit (Oryctolagus cuniculus) was referred because of a chronic obstructive rhinitis not resolving despite antibiotic treatments. Computed tomography examination revealed 2 sub-obstructive structures of mineral density in the right nasal cavity and nasopharynx. Neoplasia and rhinolithiasis were the main differential diagnoses. A dorsal rhinostomy was performed and 1 mineralized lesion was removed. Infrared spectrophotometric and histological examinations of the lesion and nasal mucosa were consistent with a 100% calcium carbonate rhinolith with bacterial colonization and chronic lymphocytic rhinitis. Clinical signs improved during the first 4 wk following surgery. However, despite inhaled anti-inflammatory treatment, the rabbit's condition deteriorated when the rhinostomy site closed, and she died 7 wk after surgery. Rhinolith and lymphocytic rhinitis should be considered as differential diagnoses for upper respiratory tract signs in rabbits resistant to antimicrobial treatment. Key clinical message: Rhinolithiasis and chronic lymphocytic rhinitis should be included in the differential diagnoses of rabbits presenting with chronic obstructive upper respiratory tract signs characterized by purulent nasal discharge and failure of treatment despite adequate antimicrobial therapy, especially with unilateral signs. Computed tomography and rhinoscopy with biopsies are suggested to explore those possibilities.
Each pack of Angeliq covers 28 days of treatment. Treatment is continuous, which means that the next pack follows immediately without a break. The tablets are to be swallowed whole with some liquid irrespective of food intake and should preferably be taken at the same time every day. In case a tablet is forgotten, it should be taken as soon as possible. If more than 24 hours have elapsed, the missed tablet should not be taken. If several tablets are forgotten, bleeding may occur.

Women who do not take estrogens or women who change from a continuous combination product may start treatment at any time. Women changing from a continuous sequential or cyclic hormone therapy (HT) should complete the current cycle of therapy before initiating Angeliq therapy.
Background/purpose: Laparoscopic sleeve gastrectomy (LSG) has been defined as an innovative surgical method for the treatment of obesity and is progressively applied worldwide. Nutritional deficiencies are identified as the possible complications of bariatric surgery. However, data on result of sleeve gastrectomy regarding energy-protein status, nutrient deficiencies and body composition are limited. The purpose of this study is to search nutritional status, body composition and biochemical parameters following LSG.

Methods: Obese subjects (N:55) scheduled for sleeve gastrectomy were included in this study. Preoperative and postoperative (1, 3 and 6th months) protein-energy and other nutrient consumptions, eating habits, food consumption diversity were evaluated with food frequency questionnaire, 3-days food diary record, three-factor eating scale and healthy eating index. Also in the pre- and postoperative period; anthropometric (weight, height, waist, hip, fat free mass) values measured and biochemical blood parameters were collected.
ABSTRACT OF THE DISCLOSURE            Aqueous solutions of 99technetium salts wherein the 99technetium is in reduced valency state, when administered to mammals, permit identification of the skeleton and of calcareous tumors by scintigraphy (radiographic scanning).  The solutions are conveniently prepared by mixing one or more phosphonic acids (or their salts) with one or more reducing salts, and adding the mixture to an aqueous solution of a pharmaceutically acceptable 99pertechnetate salt.  Reduction of the valence of the technetium occurs rapidly, and the resulting solution is adequately stable for use in scintigraphy.          The phosphonic acid and reducing salt components can be premixed.  Aqueous solutions of the premix are stable for long periods of time in the absence of free oxygen and the premix is stable to air so long as it is dry.                             -A-
This is a randomized, blinded, placebo-controlled trial in infants born at less than 32 weeks gestation, who are admitted to the Newborn Intensive Care Unit at University of Cincinnati Medical Center, Cincinnati, Ohio. Infants are randomized to receive either 4 meq/kg/day supplemental sodium or an equal amount of sterile water on days of life 7-35. Institutional data from 2008 revealed that a sample size of 56 infants completing the study will detect a 15% difference in the primary outcome of weight gain with 80% power and an alpha error of 0.05. Allowing that 33% drop-out rate (infants may be transferred to another hospital, expire, or be discharged prior to day of life 35), we choose to randomize 75 infants. Calorie intake, serum sodium, weight gain, urine sodium were monitored weekly till 35 days of life or discharge. Infants were assessed for common morbidities associated with prematurity including bronchopulmonary dysplasia, systemic hypertension, late-onset sepsis, necrotizing enterocolitis and retinopathy of prematurity.
Estrogen plays a pivotal role in the early stage of sex differentiation in teleost. However, the underlying mechanisms of estrogen-induced feminization process are still needed for further clarification. Here, the comparative analysis of whole-transcriptome RNA sequencing was conducted between 17beta-Estradiol induced feminized XY (E-XY) gonads and control gonads (C) in Takifugu rubripes. A total of 57 miRNAs, 65 lncRNAs, and 4 circRNAs were found to be expressed at lower levels in control-XY (C-XY) than that in control-XX (C-XX), and were up-regulated in XY during E2-induced feminization process. The expression levels of 24 miRNAs, and 55 lncRNAs were higher in C-XY than that in C-XX, and were down-regulated in E2-treated XY. Furthermore, a correlation analysis was performed between miRNA-seq and mRNA-seq data. In C-XX/C-XY, 114 differential expression (DE) miRNAs were predicted to target to 904 differential expression genes (DEGs), while in C-XY/E-XY, 226 DEmiRNAs were predicted to target to 2,048 DEGs. In C-XX/C-XY, and C-XY/E-XY, KEGG pathway enrichment analysis showed that those targeted genes were mainly enriched in MAPK signaling, calcium signaling, steroid hormone biosynthesis and ovarian steroidogenesis pathway. Additionally, the competitive endogenous RNA (ceRNA) regulatory network was constructed by 24 miRNAs, 21 lncRNAs, 4 circRNAs and 5 key sex-related genes. These findings suggested that the expression of critical genes in sex differentiation were altered in E2-treated XY T. rubripes may via the lncRNA-miRNA-mRNA regulation network to facilitate the differentiation and maintenance of ovaries. Our results provide a new insight into the comprehensive understanding of the effects of estrogen signaling pathways on sex differentiation in teleost gonads.
This is a single arm longitudinal trial. We will recruit up to 40 caregivers of young adults with intellectual and developmental disabilities (IDD). This is a 12-week social support, resources, and stress reduction intervention delivered in person to a group of caregivers of young adults IDD. Participants will be asked to attend one 2 hour group session each week. All sessions will have a 1-hour discussion on resources and social support and 1-hour of yoga. All yoga sessions will be taught by 200 Registered Yoga Teacher certified instructors. Outcome assessments will be collected at baseline and after the 12-week intervention.
Pryor, JL, Sweet, D, Rosbrook, P, Qiao, J, Hess, HW, and Looney, DP. Resistance training in the heat: Mechanisms of hypertrophy and performance enhancement. J Strength Cond Res 38(7): 1350-1357, 2024-The addition of heat stress to resistance exercise or heated resistance exercise (HRE) is growing in popularity as emerging evidence indicates altered neuromuscular function and an amplification of several mechanistic targets of protein synthesis. Studies demonstrating increased protein synthesis activity have shown temperature-dependent mammalian target of rapamycin phosphorylation, supplemental calcium release, augmented heat shock protein expression, and altered immune and hormone activity. These intriguing observations have largely stemmed from myotube, isolated muscle fiber, or rodent models using passive heating alone or in combination with immobilization or injury models. A growing number of translational studies in humans show comparable results employing local tissue or whole-body heat with and without resistance exercise. While few, these translational studies are immensely valuable as they are most applicable to sport and exercise. As such, this brief narrative review aims to discuss evidence primarily from human HRE studies detailing the neuromuscular, hormonal, and molecular responses to HRE and subsequent strength and hypertrophy adaptations. Much remains unknown in this exciting new area of inquiry from both a mechanistic and functional perspective warranting continued research.
Osteosarcoma is an extremely aggressive bone cancer with poor prognosis. Nε-(1-Carboxymethyl)-L-lysine (CML), an advanced glycation end product (AGE), can link to cancer progression, tumorigenesis and metastasis, although the underlying mechanism remains unclear. The role of CML in osteosarcoma progression is still unclear. We hypothesized that CML could promote migration, invasion, and stemness in osteosarcoma cells. CML and its receptor (RAGE; receptor for AGE) were higher expressed at advanced stages in human osteosarcoma tissues. In mouse models, which streptozotocin was administered to induce CML accumulation in the body, the subcutaneous tumor growth was not affected, but the tumor metastasis using tail vein injection model was enhanced. In cell models (MG63 and U2OS cells), CML enhanced tumor sphere formation and acquisition of cancer stem cell characteristics, induced migration and invasion abilities, as well as triggered the epithelial-mesenchymal transition process, which were associated with RAGE expression and activation of downstream signaling pathways, especially the ERK/NFκB pathway. RAGE inhibition elicited CML-induced cell migration, invasion, and stemness through RAGE-mediated ERK/NFκB pathway. These results revealed a crucial role for CML in driving stemness and metastasis in osteosarcoma. These findings uncover a potential CML/RAGE connection and mechanism to osteosarcoma progression and set the stage for further investigation.
The invention discloses a single-domain antibody targeting human programmed death factor PD-1 and humanized variants thereof. The VHH chain includes CDR1 shown in SEQ ID NO. 2, CDR2 shown in SEQ ID NO. 3 and CDR3 shown in SEQ ID NO. 4. The single domain antibody of the target PD-1 can block the interaction between PD-1 and PD-L1, thereby having wide biological application value and clinical application value and laying a new material foundation for the development of therapeutic or diagnostic drugs of the target PD-1.
Because of the kidneys' major role in vitamin D metabolism, most patients with kidney failure on dialysis have biochemical abnormalities that include vitamin D deficiency and high levels of phosphate, fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). All of these abnormalities are associated with cardiovascular disease, bone disease, and death and are major reasons why nephrologists have treated patients on dialysis with activated vitamin D agents for over 30 years. Current guidelines, however, encourage nephrologists to use high doses of vitamin D in order to lower PTH levels to pre-specified treatment targets. This approach to treatment has not been proven to improve health and survival, and may be associated with several harms, including further increasing levels of FGF-23 (a major cardiovascular risk factor), increasing calcium levels, which may promote vascular calcification, low turnover bone disease, and interruptions in vitamin D treatments.

Administering a low, stable dose of vitamin D may be safer and more effective than the current standard of care. The De-emphasize PTH (DePTH) Study is a pragmatic randomized clinical trial of 90 patients on hemodialysis in Seattle, WA, USA that tests whether a low fixed-dose of oral calcitriol (the active form of vitamin D; study intervention) is more safe, effective, and feasible compared with the current usual care. Participants will be recruited at their hemodialysis treatment centers and randomized in a 1:1 ratio to one of these two treatment strategies and followed over 12 months. Participants randomized to the study intervention will receive a fixed dose of calcitriol 0.5 mcg three times a week at their dialysis treatment sessions regardless of PTH level over the ensuing 12 months. Participants randomized to usual care will maintain the existing approach to treating abnormal mineral metabolism using vitamin D doses titrated to monthly to quarterly measurements of PTH. The outcomes for this trial are a panel of blood-based measurements of bone and vascular health that will be drawn at the same time as the blood work done monthly as part of routine dialysis care.
PURPOSE:To obtain the title composition having an improved amount of fluorine taken, excellently preventing effects on dental caries by blending fluorine ion with calcium ion, a substance of promoting formation of colloid of the reaction product of both the ions and inorganic powder except phosphates. CONSTITUTION:(A) A water-soluble hydrogen fluoride (e.g. sodium fluoride) is blended with (B) a water-soluble calcium salt (e.g. glucose-1-calcium phosphate-tetrahydrate), (C) a substance of promoting formation of colloid of the reaction product of both the components A and B, such as sucrose phosphoric ester, sucrose sulfuric ester or ascorbic acid derivative and (D) inorganic powder (e.g. zeolite or alumina) except phosphates to form colloid of fluoride having extremely small particle size. The blending ratio of the components of F ion: Ca ion: component C=0.1-10:1:0.05-20 and the component D is preferably 20-50wt.%. Content of fluorine in the composition is 10-100,000ppm, especially preferably 150-60,000ppm.
Sustainable attention, effective visual-spatial perception, and motor control skills are considered highly important for achieving superior athletic performance. The aim of the current study was to investigate hemispheric synchronization patterns of brain electrical activation related to successful and unsuccessful shots of archers using electroencephalography (EEG). This study involved 16 elite archers, each shooting 36 arrows. The 10 shots closest to the target's center were successful, while the 10 farthest shots were unsuccessful. The transformed EEG data, obtained through surface Laplacian filtering, were divided into 5 sub-bands (theta, alpha1, alpha2, beta1, beta2) by calculating the alpha peak frequencies. The synchronization values of the electrode pairs were calculated using the Phase Locking Value (PLV) method. To compare the EEG data for successful and unsuccessful shots in all frequency bands, the linear mixed models were fitted. Perceived fatigue levels were quantified using a visual analog scale (VAS). Spearman's correlation analysis was conducted to examine the relationship between fatigue and shooting performance. The results showed significantly higher coupling strength for C3-O1, C4-O2, O1-O2, F3-F4, C4-T8, T7-O2, F4-C4, C3-O2 and F4-T8 pairs during successful shooting. Moreover, the coupling strengths for F3-O2, F4-T7, C3-C4, C3-T8, T7-T8, C4-O1, F3-T8, and F4-O2 were significantly higher in unsuccessful shooting. The current findings revealed differences in the synchronization patterns associated with shooting performance. It is observed that visual-motor performance is correlated with an increase in cortical synchronization values during successful shots. These findings have the potential to serve as a theoretical reference that contributes to superior performance.
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder with systemic implications, potentially affecting musculoskeletal health. This study aimed to assess shoulder muscle strength and joint repositioning accuracy in individuals with T2DM, exploring potential correlations and shedding light on the musculoskeletal consequences of the condition. The objectives were two-fold: (1) to assess and compare shoulder strength and joint repositioning accuracy between individuals with T2DM and asymptomatic counterparts, and (2) to examine the correlation between shoulder strength and joint repositioning accuracy in individuals with T2DM.
METHODS: A cross-sectional study enrolled 172 participants using the convenience sampling method, including 86 individuals with T2DM and an age-matched asymptomatic group (n = 86). Shoulder strength was assessed using a handheld dynamometer, while joint repositioning accuracy was evaluated with an electronic digital inclinometer.
RESULTS: Individuals with T2DM exhibited reduced shoulder muscle strength compared to asymptomatic individuals (p < 0.001). Additionally, joint repositioning accuracy was significantly lower in the T2DM group (p < 0.001). Negative correlations were observed between shoulder strength and joint repositioning accuracy in various directions (ranging from -0.29 to -0.46, p < 0.001), indicating that higher muscle strength was associated with improved joint repositioning accuracy in individuals with T2DM.
CONCLUSION: This study highlights the significant impact of T2DM on shoulder muscle strength and joint repositioning accuracy. Reduced strength and impaired accuracy are evident in individuals with T2DM, emphasizing the importance of addressing musculoskeletal aspects in diabetes management. The negative correlations suggest that enhancing shoulder muscle strength may lead to improved joint repositioning accuracy, potentially contributing to enhanced physical functioning in this population.
The present invention relates to a system and a method for providing food information using the internet allowing a food customer to easily and accurately receive food information including nutritional contents, raw materials, and others of a food and also allowing a food supplier to publicize a food to the food customer while continuously providing updated information on the food so that both of the food customer and the food supplier can earn benefits. The present invention provides the system for providing food information using the internet comprising a food customer terminal for inputting information on a food being searched; and a food information management server for receiving the information on the food inputted by the food customer terminal and displaying a screen of a food information list while managing the registration of the food information list. The system for providing food information using the internet further comprises a food supplier terminal for transmitting existing food information or new food information to the food information management server. The food information management server comprises a food information management means for managing food information; and a food information searching means for searching the food information list by inputting the information on the food. The food information management server further comprises a client information management means for managing information on clients including the food customer and the food supplier. The food information management server further comprises a payment information management means for managing payment information including the costs for buying and selling a food from the food information list. [Reference numerals] (100) Food customer terminal; (200) Food supplier terminal; (300) Food information management server; (AA) Communication network
Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever, muscle pain, and even death in humans or ruminants. However, there are no approved antiviral drugs that prevent or treat RVFV infection. While therapeutic antibodies have shown promising potential for prevention or treatment in several studies, many studies are ongoing, especially in the field of infectious diseases. Among these studies, the mRNA-LNP platform shows great potential for application, following the COVID-19 pandemic. Previously, we have obtained a neutralizing antibody against RVFV, which was named A38 protein and verified to have a high binding and neutralization ability. In this study, we aimed to identify an effectively optimized sequence and expressed the prioritized mRNA-encoded antibody in vitro. Notably, we effectively expressed mRNA-encoded protein and used the mRNA-LNP platform to generate A38-mRNA-LNP. Pharmacokinetic experiments were conducted in vivo and set up in two groups of mRNA-A38 group and A38 protein group, which were derived from mRNA-LNP and plasmid DNA-expressed proteins, respectively. A38-mRNA-LNPs were administrated by intramuscular injection, A38 proteins were administrated by intravenous administration, and their unique ability to maintain long-lasting protein concentrations by mRNA-encoded protein was demonstrated with the mRNA-encoded protein providing a longer circulating half-life compared to injection of the free A38 protein. These preclinical data on the mRNA-encoded antibody highlighted its potential to prevent infectious diseases in the future.
PURPOSE:An antithrombotic agent containing a benzisothiazoline derivative as an active constituent. CONSTITUTION:An antithrombotic agent containing a compound of formula I (R is H or 1-10C alkyl; X is halogen) as an active constituent. The daily dose thereof is 10-40mg/kg administered once - in divided in several fractions. The dosage form thereof is an injection or oral agent, e.g. capsule, tablet or dust. The compound of formula I which is an active constituent is obtained by reacting a compound of formula II or a reactive derivative thereof with a compound of formula III at 20-100 deg.C, preferably 30-70 deg.C, in an organic solvent, e.g. benzene, isolating the compound of formula V or subjecting the resultant product to the ring closing reaction without the isolation. The ring closing reaction is carried out by adding a halogen solution to the reaction product in the presence of an organic solvent, e.g. CCl4, at 10-30 deg.C.