anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: People with homonymous hemianopia (HH) benefit from applying compensatory scanning behaviour that limits the consequences of HH in a specific task. The aim of the study is to (i) review the current literature on task-specific scanning behaviour that improves performance and (ii) identify differences between this performance-enhancing scanning behaviour and scanning behaviour that is spontaneously adopted or acquired through training.
MATERIALS AND METHODS: The databases PsycInfo, Medline, and Web of Science were searched for articles on scanning behaviour in people with HH.
RESULTS: The final sample contained 60 articles, reporting on three main tasks, i.e., search (N = 17), reading (N = 16) and mobility (N = 14), and other tasks (N = 18). Five articles reported on two different tasks. Specific scanning behaviour related to task performance in search, reading, and mobility tasks. In search and reading tasks, spontaneous adaptations differed from this performance-enhancing scanning behaviour. Training could induce adaptations in scanning behaviour, enhancing performance in these two tasks. For mobility tasks, limited to no information was found on spontaneous and training-induced adaptations to scanning behaviour.
CONCLUSIONS: Performance-enhancing scanning behaviour is mainly task-specific. Spontaneous development of such scanning behaviour is rare. Luckily, current compensatory scanning training programs can induce such scanning behaviour, which confirms that providing scanning training is important.IMPLICATIONS FOR REHABILITATIONScanning behaviour that improves performance in people with homonymous hemianopia (HH) is task-specific.Most people with HH do not spontaneously adopt scanning behaviour that improves performance.Compensatory scanning training can induce performance-enhancing scanning behaviour.
Steroid-induced avascular necrosis (AVN) of the lower extremity is a destructive process of the bone found in patients who have been treated with these medications for a variety of medical conditions. There are several proposed etiologies for development of this condition, however much debate still remains for the exact pathophysiology. The main clinical characteristics include edema, arthralgias, and restricted joint range of motion. Diagnostic imaging is a key aspect in the analysis of this pathologic process. When steroid-induced AVN affects multiple bones, this atypical presentation is difficult to treat due to its diffuse nature, therefore surgical options are limited. In these cases, conservative therapy is targeted toward pain relief and preserving joint range of motion. This review aims to provide an overview on the presentation of steroid-induced AVN in the foot and ankle, outline the pathophysiology of the process, and describe a variety of both conservative and surgical treatment options. A case study is provided to showcase a patient presentation of diffuse steroid-induced AVN of the foot and ankle and their course of treatment.Levels of Evidence: Level V: Expert opinion.
PURPOSE: This systematic review aimed to evaluate the effects of singing as an intervention for aging voice.
METHOD: Quantitative studies of interventions for older adults with any medical condition that involves singing as training were reviewed, measured by respiration, phonation, and posture, which are the physical functions related to the aging voice. English and Chinese studies published until April 2024 were searched using 31 electronic databases, and seven studies were included. The included articles were assessed according to the Grading of Recommendations, Assessment, Development, and Evaluations rubric.
RESULTS: Seven studies were included. These studies reported outcome measures that were related to respiratory functions only. For the intervention effect, statistically significant improvements were observed in five of the included studies, among which three studies had large effect sizes. The overall level of evidence of the included studies was not high, with three studies having moderate levels and the rest having lower levels. The intervention activities included trainings other than singing. These non-singing training items may have caused co-intervention bias in the study results.
CONCLUSIONS: This systematic review suggests that singing as an intervention for older adults with respiratory and cognitive problems could improve respiration and respiratory-phonatory control. However, none of the included studies covers the other two of the physical functions related to aging voice (phonatory and postural functions). The overall level of evidence of the included studies was not high either. There is a need for more research evidence in singing-based intervention specifically for patient with aging voice.
Assessing the extent of damage to the posterior limb of the internal capsule (PLIC) is important for early prediction of clinical outcomes in intracerebral hemorrhage (ICH) patients. Currently, using MRI to reconstruct the extent of damage to PLIC is not suitable for quick assessment of prognosis in emergency settings. We aimed to investigate whether the PLIC damage quantified by non-contrast computed tomography (NCCT) is associated with clinical outcomes after basal ganglia intracerebral hemorrhage (BG-ICH). This study retrospectively included 146 BG-ICH patients from the Department of Neurosurgery at the Second Affiliated Hospital of Chongqing Medical University. The damage to the PLIC was quantified using Tangency X measured by NCCT. The importance of features is determined using the Boruta algorithm and Least Absolute Shrinkage and Selection Operator (LASSO) regression. Multivariate logistic regression models were established to examine the impact of PLIC damage on outcomes. Restricted Cubic Splines (RCS) were used to explore potential nonlinear relationships, and Receiver Operating Characteristic (ROC) curves were used to compare the predictive performance of Tangency X with other scoring systems for 6-month neurological outcomes (poor outcomes [mRS: 3-6]). In the multivariate logistic regression adjusting for all covariates, Tangency X was independently associated with an increased risk of poor outcomes (OR = 1.32, 95% CI: 1.17-1.52) in BG-ICH patients. There is a nonlinear relationship between Tangency X and poor outcomes. Specifically, the risk of poor outcomes increases by 1.29 times (OR = 1.29, 95% CI: 1.09-1.67) for each additional 1 mm increase in Tangency X beyond 4 mm. We next observed that the AUC for Tangency X in predicting poor outcomes is 0.8511. The extent of PLIC damage measured by NCCT may represent a promising predictor of poor outcomes after BG-ICH.
All persons with diabetes will receive text messages regarding how to access their HbA1c results and receive links providing information to assist them in self-care behaviors related to their diabetes. All support persons will also receive materials about type 1 diabetes and how to provide helpful support to the person with diabetes.
PURPOSE:To surely diagnose a redionera bacterium infectious disease in the initial period of the crisis with a simple operation by specifically separating and refining an antiredionera bacterium polysaccharide antibody (PS antibody) from the resionera bacterium antibody prepd. by immunization, sensitizing the same with a latex and detecting a polysaccharide antigen by the reverse passive latex agglutination reaction. CONSTITUTION:The latex used for producing this sensitized latex is the latex consisting of synthetic high-polymer latex particles consisting of polystyrene, carboxylated polystyrene, etc. The redionera bacteria are obtainable by making carbon dioxide culture using a B-CYE agar medium, etc. The antiredionera bacterium antibody is obtd. by subjecting the bacteria to a prescribed treatment and immunizing the same with a rabbit, etc. The PS antibody specifically separated from such antibody is sensitized with the latex particles. Since the PS antibody sensitized latex is agglutinated by the redionera bacterium polysaccharide antigen, the agglutination reaction is eventually effected if the same antigen exists in the heated bodily fluid or the dilute fluid thereof.
The anal fistula plug procedure was performed as followings. A fistula probe was used to identify fistula tracts, and internal and external openings. Gentle mechanical debridement was performed with a blunt curette to remove the necrotic tissue with care not to enlarge the track, then hydrogen peroxide and sterile saline were used to repeatedly to irrigate the fistula. The anal fistutla plug was filled into the fistula, and sutured with a figure-of-eight 2-to-0 Vicryl suture to ensure the plug was fixed in the internal opening of the fistula, avoiding the anal fistula plug being extruded. Trimming the plug at the external fistula and the external opening was left open to ensure adequate drainage.
The most frequent time-loss injuries in sports are hamstring injuries, which are particularly common in modalities that involve rapid accelerations and decelerations like high-speed running. The hamstring muscle group is more susceptible to stresses because of the way it is anatomically arranged.These injuries are more common in sprinters than in other athletes.Ballistic motions like sprinting are typical in most contact and non-contact sports. The most frequent type of activity during sprinting is the running stride. The muscles aggressively extend and contract throughout each stride, forcing the linked segments to accelerate and slow down.In most club-level sports like football, cricket, sprinters and rugby sprinting is a crucial component of the sports and defines the performance of the athletes. If the athlete is a good sprinter he will perform more efficiently in sports. As sprinting is a high-intensity activity and is beneficial for athlete's general health but there are many injuries involved among these athletes. The injury can be disastrous for the athlete, resulting in extended recovery time and the possibility of persistent damage. Injuries in professional athletes are disproportionately often hamstring-related.The most common form of hamstring injury is hamstring strain which can be caused due these reasons. Hamstring injuries can be divided into three types; Grade 1 which is a hamstring pull or strain, Grade 2 partial muscle tear and Grade 3 complete muscle tear. The hamstring muscle is very important as it is involved in generating forward motion. The cause of hamstring injury can be due to multiple activities but the most common is when athletes are sprinting at maximal speeds.
This study will allow transplantation using a reduced intensity conditioning regimen for children with non-malignant diseases who lack a matched related or unrelated donor. Donors will be unrelated or partially matched related, depending upon urgency and availability. If each parent is haploidentical, the mother will be preferred, as there is evidence of reduced transplant related mortality and superior survival with a maternal donor. The risks of severe graft vs host disease (GVHD) and Epstein-Barr lymphoproliferative disorder will be reduced or eliminated by T and B cell depletion using the Miltenyi Clinimacs device. Patients with bone marrow failure syndromes, who are at high risk for rejection, will undergo pre-conditioning immune suppression with Thymoglobulin. It is recommended that patients with immunedysregulation syndromes receive pre-RIC alemtuzumab as this may reduce the risk on non-engraftment and hyperinflammatory states.

Post-transplant immune suppression will be used to prevent GVHD, as CD3 depletion does not deplete as completely as CD34+ selection. It will be rapidly weaned if no GVHD by day 100 to allow immune reconstitution.
Well-functioning MoM implants have shown an increase in serum cobalt and chromium (CoCr) ion levels from the metal debris generated from the implant wear.However, the current evidence suggests that measuring ion levels is unreliable and that increasing ion levels do not correlate with tissue damage. In addition to measuring blood and synovial fluid metal ion levels, ultrasound and MRI with metal artifact reduction sequences (MARS) have been utilized to assess periarticular reactions secondary to metal wear debris. Despite metal reduction software these scans are frequently difficult to interpret. While each of these tests has merit, at the present time there is no single diagnostic test available which delineates the key issue that demands urgent surgical intervention, i.e. tissue necrosis. It is important to have a reliable test to guide surgeons and patients in the shared decision-making process of when surgical intervention is necessary to prevent disabling tissue damage. For this reason, the current study proposes an examination of preoperative serum samples of subjects in addition to synovial fluid collected during revision surgery for biomarkers that may indicate tissue necrosis. To maximize the chance of success of identifying serum biomarkers, all samples will be analyzed using multianalyte assay, biomarker tests. The purpose of the study is to develop a biomarker assay to be used as a diagnostic tool for adverse local tissue reaction, or tissue necrosis, in a metal on metal total hip replacement.

A convenience sample of a total of 100 hip patients will be enrolled: 50 metal-on-metal revision hips, 25 metal-on-poly revision hips, and 25 pre-operative total hips (no implant, control group) will be enrolled. Preoperative blood serum samples and intraoperative synovial fluid will be obtained from all hips and used for biomarker testing. Additionally, intraoperative assessment of tissue necrosis will be assessed.
Technology-dependent children, those who rely on medical equipment such as mechanical ventilation or feeding tubes for daily care at home, are among the sickest and most vulnerable subset of children with complex chronic conditions. An estimated 600,000 children in the United States are technology dependent and live at home, and are cared for primarily by their parents. These parents report greater levels of depressive symptoms and stress than other caregiver groups. In addition, these caregivers report poor psychological and physical health that compromise their caregiving capacity and increase their use of emergency rooms (ER) for their children's care needs. Despite these adverse consequences, there are no interventions to meet the needs of these caregivers and their children. Resourcefulness Training, (cognitive-behavioral self-management intervention) has been shown to improve psychological and physical outcomes, mediate the effects of stress, and enhance the care provided to care-recipients. It will be tested in a randomized trial against an attention-only control arm. The intervention arm will receive an intervention that includes: a face-to-face session for teaching social (help-seeking) and personal (self-help) resourcefulness skills; ongoing access to video vignettes of caregivers of technology-dependent children describing resourcefulness skill application in daily life; 4 weeks of skills' reinforcement using daily journal writing; weekly phone calls for the first 4 weeks; and booster sessions at 2 and 4 months post enrollment. The Attention Control arm will receive weekly phone calls for the first 4 weeks and at 2 and 4 months post enrollment plus any usual care. The aims of the study are to: 1) Determine whether Resourcefulness Training versus Attention Control improves psychological (general mental health, depressive cognitions, depressive symptoms, appraised stress, burden) and physical outcomes (general physical health, chronic stress \[hair cortisol\]) and family functioning over 6 months in parents of technology-dependent children, after controlling for the parents' race/ethnicity, sex, family income, and children's functional status; and 2) Determine whether changes in psychological and physical outcomes and family functioning are mediated by changes in parents' levels of resourcefulness (personal and social). Data collection will take place at baseline then 6 weeks, 3 months, and 6 months post-enrollment. Our study will be the first to test a resourcefulness intervention for this caregiver population and to include male as well as female caregivers. This intervention is distinctive in that it uses web, telephone, and journal components for reinforcement-not multiple face-to-face visits that can be labor intensive. If shown to be efficacious, it can be easily replicated with other populations with strong potential for translation into practice.
Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that primary cilia are present on quiescent HSCs but exhibit a significant loss upon HSC activation which correlates with decreased levels of the ciliary protein intraflagellar transport 88 (IFT88). Ift88-knockout mice are more susceptible to chronic carbon tetrachloride-induced liver fibrosis. Mechanistic studies show that the X-linked inhibitor of apoptosis (XIAP) functions as an E3 ubiquitin ligase for IFT88. Transforming growth factor-β (TGF-β), a profibrotic factor, enhances XIAP-mediated ubiquitination of IFT88, promoting its proteasomal degradation. Blocking XIAP-mediated IFT88 degradation ablates TGF-β-induced HSC activation and liver fibrosis. These findings reveal a previously unrecognized role for ciliary homeostasis in regulating HSC activation and identify the XIAP-IFT88 axis as a potential therapeutic target for liver fibrosis.
In Phase II, CRLX101 will be administered at the RP2D in combination with capecitabine and radiation in patients with locally advanced rectal cancer for a total of 5-6 weeks, depending on the total radiation dose. A total of 3 doses of CRLX101 will be administered every other week. Surgery will take place at least 6 weeks after the completion of chemoradiotherapy.
Friedreich's ataxia (FRDA) is a progressive, autosomal recessive, multisystem degenerative disease for which there is currently no effective treatment. Recent studies suggest that lipid-soluble antioxidants may prevent the progression of neurodegeneration and lead to some reversal of cardiomyopathy.

This will be a phase Ia, unblinded, dose-escalation trial examining the toxicity and tolerability of the antioxidant idebenone in patients with FRDA. Our primary objective is to determine the maximum tolerated single dose of idebenone in patients with FRDA. Our secondary objective is to document the pharmacokinetics of single-dose idebenone in this population. We aim to enroll 48 patients divided evenly among three age cohorts: children (ages 5-11), adolescents (ages 12-17), and adults (age greater than or equal to 18). Each age cohort will be studied independently. Three patients from each cohort will receive one day of oral idebenone followed by inpatient monitoring for 72 hours. If dose-limiting toxicity (DLT) is not observed during the 72-hour study period, three new patients will receive the next highest dose. If one of three patients experiences DLT, three new patients will receive the same dose. Within each cohort, the dose will be escalated until the maximum tolerated dose (MTD) is established. The MTD will be defined as one dose below that which resulted in DLT in any two patients within a cohort.

Subsequent to the completion of this phase Ia trial, we plan to further refine the MTD for each age group in a phase Ib trial in which we will examine multiple-dose regimens over a longer study period. We hope to follow these phase I studies with a double-blinded, placebo-controlled phase II trial to further evaluate safety and to estimate the efficacy of idebenone using cardiac parameters as our primary endpoints. In addition, we are currently in the process of validating a clinical evaluation scale for FRDA that we hope to employ in measuring neurological parameters as a secondary endpoint in the phase II trial.
The present invention relates to a manufacturing method of a composition having a more improved performance by effectively extracting an active component having effects of preventing hair loss or promoting hair growth by a 5-alpha-reductase inhibition effect from a plant-derived natural material by using ultrasonic waves, and by being manufactured in a hoof shape of filling the extracted active component from the natural material in a liposome. The present invention comprises: (a) a mixing step of grinding the dried natural material, and mixing with an extract solvent in an extractor; (b) an active component extracting step of radiating the ultrasonic waves to a compound of the natural material and the extract solvent, and extracting the active component; (c) an active component concentrating step of dividing and concentrating the extracted active component; and (d) an active component drying step of drying the concentrated active component, and removing the extract solvent. The extracted active component is liposomized through a stabilization step. In the mixing step, the extract solvent is heated in an external heater, and condensed in a cooling condenser, and is supplied to the extractor. The active component extracting step is carried out while heating the extract solvent at room temperature or the temperature which is less than or equal to the boiling point of the extract solvent. An extract is collected to an additional collecting element not to the heater where the extract solvent is heated.
A two-component hair care product comprises an anhydrous carrier as a first component and an aqueous carrier as a second component separately from each other. The anhydrous carrier contains a) a branched or unbranched alkane, b) a branched or unbranched fatty alcohol, and c) a monovalent branched or monovalent unbranched C2 to C8 alcohol. Preferably, the branched or unbranched alkane is dodecane or isodecane, and the branched or unbranched fatty alcohol is selected from coconut alcohol, cetearyl alcohol, cetyl alcohol, myristyl alcohol, lauryl alcohol, and decyl alcohol. The monovalent branched or unbranched alcohol may be ethanol. The two components may be separated by a barrier until use. When mixed, the resulting emulsion may be applied to the hair. Preferably, the aqueous carrier or anhydrous carrier comprises one or more of: (d) an alkyl trimonium compound having chain length from C8 to C2, such as cetrimonium chloride; (e) a fatty alcohol propxylate comprising from 1 to 15 propoxylate groups, and (f) a fatty alcohol sulfate with an alkyl chain length from C8 to C22.
The invention discloses a medicine composition for treating kidney calculi. The composition comprises, by weight, sargentgloryvine stems, poria cocos, rhizoma sparganii, stigma maydis, plantain herb, black fruit thorns, rhizoma imperatae, lygodium japonicum, polygonum cuspidatum, achyranthes bidentata and auxiliary medicaments. The invention further discloses a use method of the medicine composition for treating kidney calculi. The method includes the first step of medicine pot cleaning, the second step of raw material preparation, the third step of raw material cleaning, the fourth step of liquid medicine preparation, the fifth step of medicine decoction, the sixth step of slow stewing with slow fire and the seventh step of medicine taking at normal temperature. The composition has the functions of promoting blood circulation to remove blood stasis, promoting circulation of qi and removing stasis, inducing diuresis and removing calculi. The composition has a good treatment effect, and side effects are small because the medicines are all Chinese herbal medicine. After the medicine composition is decocted in a conventional decoction process, people only need to take the liquid medicine obtained after decoction twice, and the composition is easy to take and can be easily accepted by mass patients.