anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is preventable disease and yet it remains the third greatest cause of death worldwide. This review focuses on recent updates in COPD research which have had an impact on our understanding of the epidemiology and pathophysiology of COPD.
RECENT FINDINGS: Epidemiological studies of COPD have moved towards trying to understand the global impact of COPD particularly in low- and middle-income countries where disease prevalence continues to increase. In addition, we are beginning to uncover the impact of air pollution on COPD development with recent work showing a relationship between air pollution and COPD exacerbations. Advances in understanding early origins and early development of COPD have the potential to intervene earlier in the disease course to prevent disease progression. Although biomarkers such as peripheral blood eosinophilia have led to trials of biologic agents in COPD suggesting we may be entering an exciting new biologic era in COPD.
SUMMARY: Recent advances suggest there may be a relationship between air pollution and COPD exacerbations. This requires further research to influence environmental policy. New clinical trials of biologics targeting TH2 inflammation in COPD suggest that targeted treatments with biologics may be a possibility COPD.
FIELD: medicine. ^ SUBSTANCE: in adolescent female patients with overweight suffering menstrual disorders of oligomenorrhea or amenorrhea type are examined for a body weight index (BWI) and blood serum leptin level measured by enzyme immunoassay. And if the BWI of the patient exceeds 25.0 kg/m2, and the leptin level is less than 32.52 ng/ml, diet therapy and graduated physical activity are prescribed. The leptin level 32.52 ng/ml and higher in the patient requires additional glucose tolerance test to a common technique to detect insulin resistance. If observing insulin resistance, the complex treatment includes the preparations to provide higher peripheral tissue sensitivity (sensitisers) to insulin. The absence of insulin resistance enables to prescribe the therapy of combined oral contraceptives with drospirenone. ^ EFFECT: method allows prescribing well-timed adequate therapy for treating said disease and evaluating the efficacy of the performed therapy. ^ 3 ex
The invention discloses a method and a system for multi-mode pre-training based on single-mode induction of deep learning, which aim to deal with the difficulty of extracting features from high-dimensional modal data and consider the effective fusion of high-order correlation in the main challenge of multi-mode image histology classification. Specifically, the present invention first proposes a set of multi-headed self-care encoders to capture global structured features in long sequences. The present invention then designs a masking patch modeling paradigm that masks random patch features from a fixed length contiguous subsequence of high resolution images to capture potential features. Finally, the invention combines the classification marks of the paired modes and provides a triplet learning module for learning the high-order correlation and extracting the global features. After pre-training, simple fine tuning can be used to obtain classification results. The invention can be used in the fields of visual question answering, image processing, automatic driving, medical treatment and the like.
PROBLEM TO BE SOLVED: To obtain a composition having a hypersexual action (tonic aphrodisiac action) based on a mild anti-stress action by including the hot water extract of the culture mycelia of Cordyceps sinensis Sacc. as an active ingredient. SOLUTION: The mycelia of Cordyceps sinensis Sacc. [preferably Cordyceps sinensis MF-20008 (FERM BP-5149)] is sufficiently proliferated by a liquid culture method or by a solid culture method using a culture medium comprising a malt extract, a yeast extract, peptone, potato broth, glucose, vitamins, amino acids, nucleic acids, proteins and, if necessary, the ingredients of a host such as an insect at a pH of 4-7 at a culture temperature of 15-32 deg.C at a stirring rate of 50-500rpm for 3-10 days. When a large amount of the mycelia are cultured, an aeration stirring liquid culture is preferably carried out. After the culture, the cultured mycelia are extracted with 60-100 deg.C hot water, and the extraction residues are removed. The extract is used as an active ingredient for the objective composition as such or after treated.
PURPOSE:To keep stable quality of chitosan for a long time, by sealing chitosan in a container made of a packaging material with moistureproofness and gas- barrier performance. CONSTITUTION:Chitosan is preserved in a container made of a packaging material with moistureproofness and gas-barrier performance. The moisture permeability of the packaging material is to be 0-3.0g/m<2>.24h.atm and the oxygen permeability is to be 0-140-cc/m<2>.24h.atm. The packaging material is to be an aluminum based film and the chitosan is to be a product passed 32-400mesh. When a container with a cap is used, the cap part is to be tightly closed with a tape, and when a package with a film such as an aluminum vapor deposition film, an inner bag made of polyethylene, etc., preferably with an outer bag of an aluminum vapor deposition film. It is preferable to use in combination with a deoxidizer or desiccant in the chitosan preserver, or to replace the gas in the container with nitrogen gas. Thus, even if the chitosan is kept under a high temperature and high humidity condition, quality degradation such as viscosity rise is prevented and stable quality is kept for a long time.
1. Technical Result Increase in diagnosis accuracy. 2. Essence A method provides for contacting a biological sample with a first type of polypeptide reagent, comprising a specific epitope specific for a first type of HCV virus and/or with a specific epitope specific for a first type cluster of HCV virus and assaying for the presence of epitope-antibody. The method further provides for contacting a biological sample with a second type of polypeptide reagent, comprising a specific epitope specific for a second type of HCV virus and/or with a specific epitope specific for a second type cluster of HCV virus and assaying for the presence of epitope-antibody. The polypeptides applied in this method comprise a sequence a type specific or type-cluster specific epitopes or corresponding amino acids. 3. Field of Application Medicine.  Figures: 4
FIELD: immunology. SUBSTANCE: chemical substances isolated from the centaury herb show different action spectrum in relation to immunocompetent cells. After treatment of cells with total secoiridoides the content of EAC-POК is decreased significantly, and after treatment of that with total xanthone compounds the content of E-POК is increased considerably. Fractions isolated from the centaury herb ( total xanthone and secoiridoides ) show more broad action spectrum on immunocompetent cells ( they effect on T- and B-lymphocytes), but known substance of plant origin effects at T-lymphocytes only. Centaury herb infusion containing xanthones and secoiridoides can be used for immunomodulation both T- and B-system of immunity. EFFECT: detection of plant origin agents showing broad action spectrum on immune system.
The prevalence of chronic widespread pain (CWP) in individuals infected with the human immunodeficiency virus (HIV-1) includes regional and widespread musculoskeletal pain of neuropathic and inflammatory nature. HIV-related CWP leads to 10x greater odds of functional impairment. However, the specific mechanisms that contribute to CWP in HIV are not understood. Thus, pharmacological and non-pharmacological approaches to mitigate CWP have had minimal benefits, contributing to an overreliance on opioids and alarming rise in addiction and overdose. The overall objective of this study is to address the gap in the knowledge of the pathogenesis of HIV-related CWP. Specifically, the role of impaired endogenous opioid synthesis/release from leukocytes in people with HIV (PWH) who self-report CWP will be explored. Leukocytes (neutrophils, monocytes/macrophages, and lymphocytes) are a rich source of opioid peptides (Met-enkephalin, dynorphin A, β-endorphin) that inhibit nociception by binding to peripheral opioid receptors. Therefore, to establish whether decreased peripheral opioid peptides correlate with experimental pain measures in PWH with self-reported CWP, quantitative sensory testing (QST) will be completed before and after administration of methylnaltrexone bromide (RELISTOR), a clinically available, peripherally acting opioid receptor antagonist.
Fully endoscopic microvascular decompression (MVD) of the facial nerve is the main surgical treatment for hemifacial spasm. However, the technique presents distinct surgical challenges. We retrospectively analyzed prior cases to consolidate surgical insights and assess clinical outcomes. Clinical data from 16 patients with facial nerve spasms treated at the Department of Neurosurgery in the First Affiliated Hospital of Bengbu Medical College, between August 2020 and July 2023, were retrospectively examined. Preoperatively, all patients underwent magnetic resonance angiography to detect any offending blood vessels; ascertain the relationship between offending vessels, facial nerves, and the brainstem; and detect any cerebellopontine angle lesions. Surgery involved endoscopic MVD of the facial nerve using a mini Sigmoid sinus posterior approach. Various operative nuances were summarized and analyzed, and clinical efficacy, including postoperative complications and the extent of relief from facial paralysis, was evaluated. Fully endoscopic MVD was completed in all patients, with the offending vessels identified and adequately padded during surgery. The offending vessels were anterior inferior cerebellar artery in 12 cases (75%), vertebral artery in 3 cases (18.75%), and posterior inferior cerebellar artery in 1 case (6.25%). Intraoperative electrophysiological monitoring revealed that the lateral spread response of the facial nerve vanished in 15 cases and remained unchanged in 1 case. Postoperative facial spasms were promptly alleviated in 15 cases (93.75%) and delayed in 1 case (6.25%). Two cases of postoperative complications were recorded-one intracranial infection and one case of tinnitus-both were resolved or mitigated with treatment. All patients were subject to follow-up, with no instances of recurrence or mortality. Fully endoscopic MVD of the facial nerve is safe and effective. Proficiency in endoscopy and surgical skills are vital for performing this procedure.
Severe Dermatologic Reactions

Advise patients about the signs and symptoms of serious skin manifestations. Instruct patients to stop taking Vancomycin Hydrochloride Capsules immediately and promptly seek medical attention at the first signs or symptoms of skin rash, mucosal lesions or blisters [see Warnings and Precautions (5.5)]. 

Antibacterial Resistance

Patients should be counseled that antibacterial drugs including Vancomycin Hydrochloride should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Vancomycin Hydrochloride is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Vancomycin Hydrochloride or other antibacterial drugs in the future.
Participants in this group will receive 2 fitness assessment or career counseling sessions. Each session will last 60-90 minutes over a 2-week period. Upon completion of this arm, participants will be offered the choice to start ART therapy.
Obstructive sleep apnea (OSA) is believed to contribute significantly to atrial fibrillation (AF) development in certain patients. Recent studies indicate a rising risk of AF with increasing OSA severity. However, the commonly used apnea-hypopnea index in clinical practice may not adequately account for the potential cardiovascular risks associated with OSA. 1) Objective: to propose and explore a novel method for assessing OSA severity considering potential connection to cardiac arrhythmias. 2) Method: the approach utilizes cross-recurrence features to characterize OSA and AF by considering the relationships among oxygen desaturation, pulse arrival time, and heart-beat intervals. Multinomial logistic regression models were trained to predict four levels of OSA severity and four groups related to heart rhythm issues. The rank biserial correlation coefficient, rrb, was used to estimate effect size for statistical analysis. The investigation was conducted using the MESA database, which includes polysomnography data from 2055 subjects. 3) Results: a derived cross-recurrence-based index showed a significant association with a higher OSA severity (p 0.01) and the presence of AF (p 0.01). Additionally, the proposed index had a significantly larger effect, rrb, than the conventional apnea-hypopnea index in differentiating increasingly severe heart rhythm issue groups: 0.14 0.06, 0.33 0.10, and 0.41 0.07. 4) Significance: the proposed method holds relevance as a supplementary diagnostic tool for assessing the authentic state of sleep apnea in clinical practice.
Protein hydrolysate compositions and methods of making the same are disclosed. The protein hydrolysate composition has a protein-rich organic content. The protein hydrolysate composition may be substantially free of exogenous chelating agents, chaotropic agents and surfactants. The protein hydrolysate composition may be low in ash content. The protein hydrolysate composition is produced by processing a biomass, e.g., a microbial biomass, through a combination of physical, chemical and/or enzymatic treatments. The protein hydrolysate may be sourced via microbial biomass from CCk as a carbon source. Also disclosed are methods of using the protein hydrolysate compositions, e.g., as a biostimulant.
This current project will be an interventional, non-invasive study examining changes in skin carotenoid levels over time in individuals who increase their carotenoid intake by taking a dietary supplement containing a known amount of carotenoids. After a two-week control period eating their normal diet, forty medical students meeting study inclusion criteria will be asked to take a dietary supplement over an eight week period of time. Students will be given twin-sachet packets of LifePak Nano supplements containing five capsules (dry ingredients) and two CR-6 Liponutrient softgel capsules (liquid ingredients, including omega-3 fatty acids and nanosized carotenoids). These will be taken twice a day with eight ounces of liquid at the morning and evening meal. SCS will be measured every 2 weeks. At the end of this period, the students will be asked to discontinue dietary supplement intake and follow their usual diet for 2 weeks then their SCS measured again.
The invention discloses a cosmetic composition and an application thereof. The composition comprises aloe and a heat clearing component, and also comprises vitamin C, collagens and/or a surfactant preferably selecting phospholipid, and the heat clearing component is one or more of Acanthopanax trifoliatus (L.) Merr., Rhizoma Coptidis, Weeping Forsythia and honeysuckle flower. A weight ratio of aloe to the heat clearing component is 0.1-1000:1, and a weight ratio of vitamin C to the collagens to the surfactant phospholipid to an aloe and heat clearing component mixture is 0.01-10:0.01-10:0.01-10:100. Aloe is compounded with the heat clearing component to realize synergistic antibiosis and anti-inflammation efficacies, benefit absorption of effective components in the composition by skins and make the effects of the effective components substantial. The vitamin C and the collagens are compounded to synergistically improve the whitening, spot removing and after-sun repairing efficacies. The surfactant phospholipid is further compounded to accelerate transdermal absorption and improve the bioavailability.
PROBLEM TO BE SOLVED: To efficiently produce granules with high extrusion granulation processability while stabilizing vitamin C-containing products even in the case that sugar alcohol is included. SOLUTION: A pharmaceutical preparation including stabilized vitamin C products is obtained by kneading and extruding a composition containing vitamin C products and erythritol. The vitamin C-containing products may be composed of free ascorbic acid and an alkaline earth metal ascorbate. The vitamin C-containing products may be combined with vitamin E-containing products. The proportion of the erythritol is about 10-90wt.% based on the total composition. This composition may contain additionally sweetener, binder, excipient and the like.
Ursodiol therapy has not been associated with liver damage. Lithocholic acid, a naturally occurring bile acid, is known to be a liver-toxic metabolite. This bile acid is formed in the gut from ursodiol less efficiently and in smaller amounts than that seen from chenodiol. Lithocholic acid is detoxified in the liver by sulfation and, although man appears to be an efficient sulfater, it is possible that some patients may have a congenital or acquired deficiency in sulfation, thereby predisposing them to lithocholate-induced liver damage.   
Abnormalities in liver enzymes have not been associated with Ursodiol therapy and, in fact, Ursodiol has been shown to decrease liver enzyme levels in liver disease. However, patients given Ursodiol should have SGOT (AST) and SGPT (ALT) measured at the initiation of therapy and thereafter as indicated by the particular clinical circumstances.
○ Chronic pain affects over 100 million adults in the US, resulting in disability, loss of work productivity, and overall reductions in health, making chronic pain a major public health problem with an economic burden estimated at $560-635 billion annually. Opioids, the most frequently prescribed class of drugs to control pain, lack evidence supporting their long-term efficacy and carry a 15-26% risk of misuse and abuse among pain patients, highlighting a critical need to develop effective non-pharmacological interventions for pain. Guided imagery (GI), a cognitive-behavioral technique for guiding patients to create multisensory, imagined scenes to increase well-being, is an effective non-pharmacological intervention for reducing pain. However, its effectiveness is limited by patients' imaging abilities. The long-term objective of this project is to reduce chronic pain and opioid use by developing an at-home virtual reality (VR)-GI intervention to improve chronic pain management using the Limbix VR Kit. Given the enhanced immersiveness and interactivity of VR, VR-GI is expected to reduce pain and reliance on opioids, as well as improve functional outcomes and mood, compared to traditional audio-only GI and usual care. The specific aims are to evaluate feasibility and usability of an at-home VRGI intervention in a 2-week clinical trial. Two 15-min VR-GI experiences that guide patients through psychoeducation, relaxation exercises, and interactive virtual worlds that allow them to control their experience of pain will be evaluated. To assess feasibility of an at-home VR-GI intervention, 36 patients with chronic pain (18 with chronic back pain, CBP, and 18 with complex regional pain syndrome, CRPS) will complete a 2-week intervention with at-home daily practice of VR-GI (n = 24) or audio-only GI (n = 12). Pre-post treatment measures of pain intensity, opioid use, functional outcomes, and mood will be collected. Intervention feasibility and patient satisfaction will be evaluated post-treatment via questionnaire and qualitative interview. This research directly addresses the need to improve pain treatment to prevent opioid use disorder.
Specific etiology of this syndrome is unknown, and there is no single diagnostic test. Adequate diagnosis requires the use not only of medical but of special psychological, educational, and social resources.

Characteristics commonly reported include: chronic history of short attention span, distractibility, emotional lability, impulsivity, and moderate-to-severe hyperactivity; minor neurological signs and abnormal EEG. Learning may or may not be impaired. The diagnosis must be based upon a complete history and evaluation of the child and not solely on the presence of one or more of these characteristics.

Drug treatment is not indicated for all children with this syndrome. Stimulants are not intended for use in the child who exhibits symptoms secondary to environmental factors and/or primary psychiatric disorders, including psychosis. Appropriate educational placement is essential and psychosocial intervention is generally necessary. When remedial measures alone are insufficient, the decision to prescribe stimulant medication will depend upon the physician's assessment of the chronicity and severity of the child's symptoms.
Mitochondria are cellular powerhouses that generate energy through the electron transport chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a compartmentalized manner, however, the mechanism underlying metabolic regulation of mtDNA function remains unknown. Here, we report that expression of tricarboxylic acid cycle enzyme succinate-CoA ligase SUCLG1 strongly correlates with ETC genes across various TCGA cancer transcriptomes. Mechanistically, SUCLG1 restricts succinyl-CoA levels to suppress the succinylation of mitochondrial RNA polymerase (POLRMT). Lysine 622 succinylation disrupts the interaction of POLRMT with mtDNA and mitochondrial transcription factors. SUCLG1-mediated POLRMT hyposuccinylation maintains mtDNA transcription, mitochondrial biogenesis, and leukemia cell proliferation. Specifically, leukemia-promoting FMS-like tyrosine kinase 3 (FLT3) mutations modulate nuclear transcription and upregulate SUCLG1 expression to reduce succinyl-CoA and POLRMT succinylation, resulting in enhanced mitobiogenesis. In line, genetic depletion of POLRMT or SUCLG1 significantly delays disease progression in mouse and humanized leukemia models. Importantly, succinyl-CoA level and POLRMT succinylation are downregulated in FLT3-mutated clinical leukemia samples, linking enhanced mitobiogenesis to cancer progression. Together, SUCLG1 connects succinyl-CoA with POLRMT succinylation to modulate mitochondrial function and cancer development.
Placebo (2 canisters) will be taken orally twice a day. Subjects will consume the placebo drink on days 1 through 28.