anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Due to global industrialization and urbanization, natural disasters, accidents, and public health emergencies happen frequently. These events cause significant loss of life and property damage to countries worldwide. In the context of frequent public emergencies, enhancing emergency logistics response capabilities is crucial, ensuring rapid supply of rescue materials and support for rescue personnel, thereby saving lives and reducing economic losses.
METHODS: In order to identify the changes and enhancement paths of the emergency logistics response capability of Chinese regions under the shocks of public emergencies, this paper innovatively constructs emergency logistics response capability measurement indicators. This paper uses the entropy weight TOPSIS method and panel quantile regression model to quantify the change and enhancement paths of China's regional emergency logistics response capability under different events.
RESULTS: It is found that: (1) The gap in emergency logistics response capability among Chinese regions is widening, with the internal difference in the eastern region higher than that in the west, while the difference in the central region is relatively low. (2) China's emergency management department can effectively transform social logistics into emergency logistics, thereby promoting the improvement of emergency logistics response capabilities. (3) Sudden geological disasters break through the limits of social logistics resources when they cross lower scales, resulting in the failure of emergency logistics response capabilities.
DISCUSSION: This paper expands research on assessing emergency logistics capabilities, addressing issues in existing assessments such as reliance on single indicators and subjective measurement methods. Additionally, it quantifies the dynamic changes in China's regional emergency logistics response capabilities under public emergencies by extending the study of event content, types, and impacts. This enhances discussions on the effects of public emergencies. Finally, from an empirical perspective, the paper explores pathways to enhance regional emergency logistics response capabilities in China. In practice, this paper assists countries worldwide in assessing whether different regions of China can effectively provide emergency support for various resources in direct investments, thus providing a scientific basis for investment decisions.
In this project, we will register outpatients with cardiovascular diseases and healthy subjects for cardiovascular health check-up in the cardiovascular research clinic of our hospital, comprehensively evaluate their cardiovascular risk factors, subclinical organ damage and cardiovascular diseases at baseline. For participants who is willing to go further, a digital-based intervention will be provided for them to improve their knowledge and behaviour on cardiovascular health. For all participants, their status on subclinical organ damage, cardiovascular diseases and events will be followed within five years. The primary outcome is the composite endpoints of cardiovascular adverse events including acute coronary syndrome, myocardial infarction, heart failure, cardiovascular death. The secondary outcomes include individual cardiovascular adverse events, all-cause mortality, subclinical organ damage including cardiac damage (left ventricular hypertrophy and diastolic dysfunction), renal damage (chronic kidney disease, microalbuminuria), and vascular damage (arterial stiffness, plaques, intima-median thickening, retina arteriosclerosis). By doing these, we will be able to build a registry study and to reveal the epidemiology of subclinical organ damage, validate the association between subclinical organ damage and cardiovascular events in Chinese, and explore the significance of digital-based intervention in the prevention from subclinical organ damage and cardiovascular diseases and events.
BACKGROUND: The Short Form 36-Item Health Survey (SF-36) is a health-related quality of life (HRQoL) measure validated in people with chronic obstructive pulmonary disease (COPD). While physical health is often more impaired than mental health in people with COPD, research on alpha-1 antitrypsin deficiency (AATD)-associated COPD is limited. This longitudinal study examines changes in physical and mental health in individuals with AATD and associated factors.
METHODS: Analyses included participants of AlphaNet, a disease management program for individuals with AATD-associated lung disease who are prescribed augmentation therapy. Norm-based SF-36 scores for mental and physical component summaries (MCS and PCS) and 8 scales were analyzed. Linear mixed models evaluated mean changes in SF-36 scores over time.
RESULTS: The study included 2165 participants (mean age 56.9 ± 10.0 years, 47.0 % female). At enrollment, mean PCS score was 37.5 ± 9.6, and mean MCS score was 51.9 ± 10.5. Mean mMRC dyspnea score was 2.3 ± 1.3; 54.6 % had ≥2 exacerbations annually, and 46.5 % used oxygen regularly. Average follow-up was 6.6 ± 3.2 years. The HRQoL remained stable; MCS improved by 0.16 points/year (p < 0.0001), while the PCS score declined by 0.49 points/year (p < 0.0001). Subscales followed similar trends.
CONCLUSIONS: At baseline, mental HRQoL scores were higher than physical HRQoL scores, indicating better mental health than physical health in this cohort with AATD-associated lung disease. Stable HRQoL with a slight improvement in mental scores over time and a small decrease in physical scores may be a unique feature of this cohort. Further studies are needed to correlate these findings with disease-specific instruments and patient physiology.
Chronic wounds are a critical and costly complication that affects millions of patients each year, especially patients suffering from diabetes, and constitute a serious global healthcare problem that needs immediate attention. In this direction, novel dressings that can integrate appropriate physicochemical and biological features, mechanical durability, and the capacity for therapy are of great clinical importance. For instance, self-healable hydrogels, with antibacterial activity and high tissue adhesion, have attracted increasing attention for wound management applications. Despite their potential, existing self-healable hydrogel networks exhibit limitations in mechanical strength and adhesion, tissue regeneration, antibacterial efficacy, and scalability, indicating a need for further improvement in the field. This review focuses on exactly these recent advances in the field with a special focus on self-healing adhesive hydrogel-based wound dressings as well as their structures, construction strategies, adhesion mechanisms, and emerging usage in the wound healing field. By shedding light on these developments, we aim to contribute to the ongoing pursuit of enhanced solutions for chronic wound care.
Recognizing the significance of drug carriers in the treatment of atherosclerotic plaque is crucial in light of the worldwide repercussions of ischemic stroke. Conservative methodologies, specifically targeted drug delivery, present encouraging substitutes that mitigate the hazards linked to invasive procedures. With the intention of illuminating their considerable significance and prospective benefits, this study examines the impact of the geometry and dimensions of drug-loaded nano-microcarriers on atherosclerotic plaque. The research utilizes a finite element approach to simulate the motion and fluid dynamics of nano-microcarriers loaded with drugs within the carotid arteries. Carriers are available in a variety of shapes and sizes to accommodate patient-specific geometries, pulsatile fluid flow, and non-Newtonian blood properties. Optimization of drug delivery is achieved through the examination of carrier interaction with the inner wall. The results demonstrated that the interaction data between particles and the inner wall of atherosclerotic plaques exhibits micro- and nanoscale patterns that are distinct. Symmetric plaques demonstrate that nanoparticles with a 0.4 shape factor and diameters below 200 nm show the highest interaction rate. Conversely, larger particles (200 and 500 nm) with shape factors of 1 demonstrate comparatively elevated interaction rates. The optimal shape factor for drug-loaded microparticles has been determined to be one, and the number of interactions increases as the diameter of the nanoparticles increases, with a significant increase observed at a shape factor of one. Asymmetric plaques exhibit the maximum interaction rates among particles that have a shape factor of 0.4 and have diameters smaller than 500 µm. The findings establish a foundation for novel therapeutic strategies, establishing nano-microparticles as auspicious contenders for accurate and efficacious drug delivery systems that inhibit plaque proliferation.
The invention relates to a traditional Chinese medicine pearl powder for treating abscess, mainly solves the problems of poor curative effect and side effect in the existing medicines for treating abscess. The powder is prepared by the following steps: taking 5g of indico naturalis, 3g of pearl (boiled in beancurd three times and ground into fine powder) and 30g of calomel; and grinding into the ultrafine powder. The chancre in the early stage can heal after the power is smeared; for the patients with rotten pain, the abscess is cleaned with licorice, and smeared along with porcine bone marrow, or smeared dryly if no hide grows; and the powder is also applicable to women with erosion of vulva. The power is used once a day. The total effective rate for treating abscess is higher than 95%, and the cure rate is higher than 80%. The powder has no toxic or side effect.
PURPOSE: To obtain a curing agent for brain edema containing a carbostyril derivative as an active component. CONSTITUTION: This curing agent contains a compound of the formula (R<1> is OANR<2> R<3> ; A is a lower alkylene; R<2> and R<3> are each H or a lower alkanoyl; a bond between carbons at 3 and 4 positions of carbostyril ring is a single bond or a double bond) or its salt in an amount of 1-70wt.%, preferably 5-50wt.% as an active component. As the compound of the formula, 1- 1-[4-(3- acetylaminopropoxy)benzoyl]-4-piperydinyl}-3,4-dihydrocarbostyril can be used. The active component can be formulated into an oral agent, an injection, a suppository, etc., after compounding with an arbitrary component in an adequate amount by a conventional method. The agent is administered at a dose of 0.6-50mg/kg/day in terms of the active component. The compound of the active component is preferably contained in a unit administration formulation in an amount of 10-1000mg.
The invention concretely relates to a formula and a preparation method of a Hui Nationality traditional Chinese medicinal six-medicine component leukemia treatment tablet. The tablet is a green high-tech Chinese herbal medicine used for treating leukemia. The tablet is a traditional Chinese medicinal tablet prepared through the following steps: mixing of glabrous sarcandra herb, Spica Prunellae, Pseudobulbus Cremastrae seu Pleiones, toads and other Chinese herbal medicines according to a certain ratio, water adding, decoction, extraction, concentration and tabletting. The tablet is mainly used for treating the leukemia, and also is used for treating throat cancer, stomach cancer, colorectal cancer and other digestive system cancers. The tablet has the characteristics of small medicine variety quantity and moderate dosage, and all the medicines are proved by modern medical science pharmacological experiments to be suitable for treating the cancers. The tablet fundamentally improves the body functions and prevents condition exacerbation at a low cost in order to recover the health of bodies.
Cohort B will assess recurrent Glioblastoma Multiforme(GBM) patients who receive AMG 386 plus bevacizumab. Because the maximum tolerated dose of this combination therapy has not yet been established, a 3x3 Phase I study was used to determine the maximum tolerated dose. As of June 6, 2014, the MTD was determined to be AMG386 30 mg/kg administered intravenously every week(dose level +1) in combination with bevacizumab at 10mg/kg administered intravenously every other week. As of July 25, 2014 the Cohort B, Phase II portion of the study was opened to accrual.
<P>PROBLEM TO BE SOLVED: To provide a liquid which is effective for recovery from all diseases of human beings, all animals such as dogs and cats, all livestock animals, all useful insects such as honey bees, all birds, all trees and all plants.  <P>SOLUTION: When a newly developed disease curing liquid is applied to diseased parts (affected sites) of human beings, all animals such as dogs and cats, all livestock animals, all useful insects such as honey bees, all birds, all trees and all plants, the diseased parts are obviously relieved. Human beings, all animals such as dogs and cats and all livestock are recovered from diseases by spraying the liquid to their mouths. When the liquid is applied to diseased parts of human beings (sites suffering from stiff shoulder, athlete's foot, foot corn, chapped skin or all skin diseases), or the liquid is sprayed into the mouths when they suffer from dull feeling in the throat (initial symptom of catching a cold), discomfort in the stomach (stomachache), heartburn or the like, the liquid exhibits immediate effect-efficacy. This can be actually experienced by themselves. Persons who actually use the liquid and are accordingly experienced the way of its use never catch a cold. This has been true for years in those who tried samples and bought commercial products of the liquid.  <P>COPYRIGHT: (C)2011,JPO&INPIT
PURPOSE: To obtain a bathing agent composition capable of ameliorating prurltus or eczema and of conducting skin care safely, and also staining no bath water and bathtub, comprising an Avena sativa Linne extract, oily ingredient(s) and surfactant. CONSTITUTION: This bathing agent composition comprises (A) an extract obtained by extracting seeds of Avena sativa Linne with water and/or a polar organic solvent (e.g. ethanol, butanol, propylene glycol, 1,3-butylene glycol, a mixture thereof), (B) pref. 10-95wt.% of at least one kind of oily ingredient pref. selected from glycerol fatty acid esters, oil-and-fat, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters and silicone oils, and (C) pref. 0.1-50wt.% of a nonionic, cationic, anionic, or amphoteric natural or synthetic surfactant.
Hydroxyurea capsules, USP are an antimetabolite available for oral use as capsules containing 500 mg hydroxyurea, USP. Inactive ingredients include colloidal silicon dioxide, FD&C Blue No. 1, FD&C Red No. 3, gelatin, magnesium stearate, titanium dioxide and black ink. The black ink contains black iron oxide, dewaxed shellac and potassium hydroxide.

Hydroxyurea is a white to off-white crystalline powder. It is non-hygroscopic and freely soluble in water, but practically insoluble in alcohol. The empirical formula is CH​4N2O2 and it has a molecular weight of 76.05. Its structural formula is:

Meets USP dissolution test 2.
The inventive emulsion of perfluororganic compounds (PFOC) has gas-transport properties, used for intravascular injection and comprises perfluorocarbon which is easy to remove from an organism, and perfluortertiary amine which is hard to remove from an organism, in addition to not less than three PFOC additives which are chosen in small quantities. Said additives are close to the main components with respect to the structure and physical and chemical properties thereof, and produce a range of PFOC having gradually fluctuating properties. Said emulsion also comprises minor additives of perfluoroalcane. The composition determines the stability of the emulsion during storage and in the blood flow, in addition to low viscosity of the PFOC emulsion, thereby providing a high dynamic oxygen capacity of the preparation and improving the supply of oxygen to tissues. In order to produce the emulsion, the stabilising agent is heated at a temperature of up to 75 °C. All components are saturated with carbon dioxide and homogenisation is carried out when the carbon dioxide is injected, thereby minimising the occurrence of peroxides and reducing reactogenicity.
The invention discloses a monoclonal antibody EEEV-6E2 resisting EEEV (Eastern Equine Encephalitis Virus) E2 protein, B-cell epitope peptide recognized by EEEV-6E2 as well as the application of the EEEV-6E2 and the B-cell epitope peptide. The invention further discloses a hybridoma cell strain which can stably secrete the EEEV-6E2 resisting the EEEV E2 protein and is named as EEEV-6E2. The microbial preservation number of the hybridoma cell strain is CGMCC No. 7007. An idiosyncratic reaction can occur between the EEEV-6E2 secreted by the hybridoma cell strain and the EEEV E2 protein while the EEEV-6E2 does not react with WEEVes/VEEVes (Western Equine Encephalitis Viruses/Venezuelan Equine Encephalitis Viruses). Secondly, the invention further discloses the B-cell epitope peptide which is specially recognized by the EEEV-6E2. The EEEV-6E2 and the specific B-cell epitope peptide, recognized by the EEEV-6E2, of the EEEV E2 protein can be used for preparing reagents for identifying and diagnosing EEEVes and other alphaviruses and lay a foundation for creating identifying and diagnosing methods of EEEV antigen clusters and other alphaviruses as well as further studying prevention and treatment measures.
Autophagy is one of the intracellular degradation pathways and maintains cellular homeostasis, regulating the stress response, cell proliferation, and signal transduction. To elucidate the role of autophagy in the maintenance of dental epithelial stem cells and the subsequent enamel formation, we analyzed autophagy-deficient mice in epithelial cells (Atg7f/f;KRT14-Cre mice), focusing on the influence of aging and stress environments. We also performed in vitro cell and organ culture experiments with an autophagy inhibitor. In young Atg7f/f;KRT14-Cre mice, morphological change was not obvious in maxillary incisors, except for the remarkable cell death in the stratum intermedium of the transitional stage. However, under stress conditions of hyperglycemia, the incisor color changed to white in diabetes Atg7f/f;KRT14-Cre mice. Regarding dental epithelial stem cells, the shape of the apical bud region of the incisor became irregular with age, and odontoma was formed in aged Atg7f/f;KRT14-Cre mice. In addition, the shape of apical bud culture cells of Atg7f/f;KRT14-Cre mice became irregular and enlarged atypically, with epigenetic changes during culture, suggesting that autophagy deficiency may induce tumorigenesis in dental epithelial cells. The epigenetic change and upregulation of p21 expression were induced by autophagy inhibition in vivo and in vitro. These findings suggest that autophagy is important for the regulation of stem cell maintenance, proliferation, and differentiation of ameloblast-lineage cells, and an autophagy disorder may induce tumorigenesis in odontogenic epithelial cells.
The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. In order to reduce the side effects of the drug for treating NAFLD or NASH, there is an urgent need to develop a new drug in the field of biomedicine, which can maintain the lipid metabolism of thyroid hormones in the liver without causing the corresponding side effects in other tissues. Accordingly, an object of the present invention is to provide a liver-targeting compound having thyroid hormone receptor agonist characteristics and a pharmaceutical composition thereof.  The compound is a compound represented by formula (1), wherein, n is an integer of 1 to 10; X is carbonyl; Y is NH group or an oxygen atom. The compound can be used for treating and/or preventing diseases caused by thyroid hormone dysregulation, and can also effectively reduce lipids in plasma and liver cells. (see formula 1)
Positive psychotherapy (PPT) seeks to understand positive emotions, psychological potentialities and healthy human / social / institutional functioning, and to apply this knowledge to help people and institutions, with a focus on prevention and promotion of mental health (SELIGMAN et al., 2005). Originally, PP focused on happiness and subjective well-being (SELIGMAN, 2010; SELIGMAN; CSIKSZENTMIHALYI, 2000). Then, the studies gained a broader view of psychological well-being and another similar proposal entitled PERMA, which is composed of the following five spheres: positive emotions - P; engagement - E; relationships - R; meaning - M; and achievement - A. (RYFF, 2013; SELIGMAN, 2012). Although positive psychology aims to be a way of looking at life, some psychotherapeutic proposals, such as positive psychotherapy (PPT), have been developed, and clinical studies have been replicated in different clinical and cultural contexts (RASHID; SELIGMAN, 2019; RICHES et al., 2016).
FIELD: medicine. SUBSTANCE: invention proposes to treat blood cells for two stages. At the first stage leukocyte cells suspension is obtained and incubated with cytokine complex and erythrocyte mass is washed out with physiological solution twice. At the second stage leukocytes are mixed with optimal dose of antibiotic and washed out erythrocytes and recovered to patient after incubation for 20 min. Method can be used for treatment of patients with severe bacterial infection. EFFECT: increased concentration of antibiotic in inflammation focus, enhanced immunological response of body. 1 tbl, 3 ex
A method of producing antibody-rich  cannabis  and honeysuckle plants, and receiving the antibodies therefrom within a human body, is described. Antibody proteins are transfected or transduced to the DNA of one or more cells of a  cannabis  or honeysuckle seed. As the  cannabis  or honeysuckle seed grows into a plant, the plant cells reproduce the antibody protein within the DNA into a plurality of cells. A human consumes the  cannabis  or honeysuckle plant. The digestive system of the human separates the antibody proteins from the DNA. Finally, the circulatory system of the human distributes the antibody proteins throughout the body.