anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
During this study, participants will perform baseline measurements such as walking and balance tests. During baseline testing, participants will be asked to perform a maximal exertion test while walking on a treadmill to determine the speed for a submaximal walking test. One week after baseline testing, the participant will have an intervention session where they drink either a beetroot juice supplement or a placebo. The placebo will taste similar to the beetroot juice and participants may not be able to tell the difference between the two different supplements. After a week, the participant will return to the lab and drink the other supplement. For example, if the participant drank the beetroot juice in the first session, then they will drink the placebo in the second session. During each intervention session, the participant will be asked to perform two treadmill tests, one with submaximal effort and one with maximal effort. After the walking tests, they will drink either the beetroot juice or placebo and have their blood drawn. They will wait at the hospital for 2-3 hours and have their blood drawn again. The participants will then complete the two treadmill tests again. The two intervention sessions will last about 4-6 hours for each session. Participation in the study will last 4-6 weeks including screening and baseline testing.
A clear aqueous dispersion of solubilised lanoline is made by intimately mixing the lanoline with a higher fatty acid alkylolamide the acyl group having 8 to 18 carbon atoms, and the alkylol group or groups having up to 5 carbon atoms, and dissolving the mixture in water.  Preferably a surface active agent is added to the lanoline/alkylolamide mixture to assist solution in water.  The alkylolamide is made by condensing a higher fatty acid with preferably a lower dialkylolamine, e.g. diethanolamine.  The product contains about 60% of the amide and includes minor proportions of soaps, ester amides etc., which may be left in, and act as the surface active agent.  As separate surface active agents these may be used, ionic or non-ionic detergents, e.g. alkyl aryl sulphonates, sulphuric esters of polyhydric alcohols, fatty acid esters of alkylol sulphonic acids, fatty acid amides of amino alkyl sulphonic acids, the corresponding water-soluble soaps including salts of alkali metals, ammonia, or alkylolamines, and poloxyethylene ethers.  In examples, about equal parts of cocoanut diethanolamide and lanoline (or a higher proportion of the amide) are melted together at 180 DEG F. in a substabtially anhydrous state, to form a clear liquid, to which is then added sodium lauryl sulphate, and triethanolamine dodecyl benzene sulphonate, and the mixture stirred for 90 mins. with water.  The liquid produced is then filtered.  The cocoanut oil compound may be replaced by other homologues, e.g. lauroyl di-iso-pro-panolamide.  Other ingredients which may be present include sodium phosphate, hexachlorophene, and also formalin as preservative.  The clear liquid produced may be used as a base for making shampoos, washing compositions, and like preparations.
More than 12 million elderly people are hospitalized each year in the United Status, frequently resulting in functional decline. Family care of hospitalized elders is important given the increasing numbers of hospitalized elders, needs for elder care in the home after hospital discharge, and responsibilities of family caregivers for providing this care. Involving family caregivers in the hospital care of their loved one may result in positive outcomes for both the elderly patients and their family caregivers. However, there is a paucity of empirical studies that have been conducted to evaluate the effectiveness of interventions to enhance family participation in caring for hospitalized elders. In the proposed study, we will build upon our prior work that has demonstrated the positive effects of theoretically-driven interventions with families of hospitalized patients and older adults at home. Among the unique contributions of this study include: (a) a randomized controlled design, (b) testing of a theoretically-driven, reproducible intervention that can be easily translated into clinical practice and widely disseminated; (c) the testing of an explanatory model to explain the effects of the intervention, (d) a prospective cost-effectiveness analysis; and (e) an intervention that begins early in the hospital stay, and (f) measurement of both short- and more long-term outcomes, up to 2 months following hospital discharge.

The primary aim of this study is to evaluate the effects of a theoretically-driven, reproducible intervention (CARE: Creating Avenues for Relative Empowerment) on the process and outcomes of hospitalized elders and their family caregivers. The secondary aims are to: (a) explore what factors moderate the effects of the intervention program (e.g., social economic status and family preferences for care participation); and (b) determine the cost-effectiveness of the CARE program. A two-group experiment will be used with 280 family caregivers of hospitalized elders. Measures of both process and outcome variables will be included, such as family caregiver beliefs, anxiety, worry, depression, role outcomes, as well as elderly patients outcomes during hospitalization and after hospital discharge. Findings from a recent pilot study with 49 family caregiver-elders dyads support undertaking this full-scale clinical trial in that family caregivers who received the CARE program, versus those who received a comparison program, had more positive coping and role outcomes and their hospitalized elderly relatives had positive outcomes during and after hospitalization.
Bariatric surgery is widely recognized as the most effective intervention for obesity and offers benefits beyond weight loss. However, not all patients achieve satisfactory weight loss, balanced changes in body composition, and resolution of comorbidities. Therefore, thorough pre- and postoperative evaluations are important to predict success and minimize adverse effects. More comprehensive assessments require broadening the focus beyond body weight and fat measurements to consider quantitative and qualitative evaluations of muscles. Introducing the concept of sarcopenia is useful for assessing the degradative and pathological changes in muscles associated with cardiometabolic function, physical performance, and other obesity-related comorbidities in patients undergoing bariatric surgery. However, there is currently no consensus or definition regarding the research and clinical use of sarcopenia in patients undergoing bariatric surgery. Therefore, this review aimed to define the concept of sarcopenia applicable to patients undergoing bariatric surgery, based on the consensus reached for sarcopenia in the general population. We also discuss the methods and significance of measuring muscle mass, quality, and strength, which are key variables requiring a comprehensive assessment.
Vitamin B12 has long been suggested to have neural nutrient effect and widely used in clinical settings for patients with peripheral nerve injury as well as complementary medicine for patients with CNS disorders, including cognitive dysfunction. Evidences showed that, although no significant improvement in cognitive function was observed in healthy elderly after vitamin B12 supplementation, some studies suggested that patients with pre-existing CNS disorder may benefit from Vitamin B12. Post operational cognitive dysfunction (POCD) is severe, and long-lasting complication that affects as high as 53% of patients in high risk surgeries. Age is an independent risk factor for POCD. Researches have shown that serum vitamin B12 level decrease with age, and methylcobalamin (active form of Vitamin B12) content in the frontal cortex of aged patients are lower than that of younger patients. However, there are no report on effect of preemptive supplementation of vitamin B12 on POCD incidence. Therefore, the current research is aimed to explore the preoperative methylcobalamin supplementation (500 mg, 3/day for 7 days before surgery) on incidence of POCD. Folic acid supplementation is a common companion for vitamin B12 treatment in clinical settings because they are in the same methionine cycle, increase of one may result in deficiency of another. So we added 5 mg, 1/day of folic acid with methylcobalamin in the treatment group.

This study will recruit patients more than 65 years old eligible for non-cardiac surgery. Patients who participate will take either vitamin B12 and folic acid supplementation or placebo for 7 days before surgery. Neuropsychological test battery (NPB) will be tested before intervention and at discharge for determination of Post operative cognitive dysfunction (POCD). Another group of non-surgical elderly participants will also be tested for NPB to account for learning effect in POCD diagnosis. The hypothesis is that preoperative vitamin B12 supplementation will reduce the incidence of POCD in elderly patients undergoing non-cardiac surgery.
Washout + Placebo Ocular Insert in each eye for 4 to 6 weeks, followed by 2.2 mg Bimatoprost Ocular Insert in each eye for 12 weeks. Note: participants also self-administered placebo ophthalmic eye drops in each eye twice a day for the first 6 weeks. After 12 weeks, 13 mg Bimatoprost Ocular Insert in each eye for an additional 12 weeks.
Stressful experiences are common among migrants and may have health implications. With the only US nationally representative data set on migration, the New Immigrant Survey, we used survey-adjusted descriptive and multivariate regression methods to examine whether victimization prior to resettlement was associated with obesity, cardiovascular disease, diabetes, arthritis, cancer, and chronic lung disease. Among foreign-born people who obtained lawful permanent residence in the US in 2003-04, 6.7 per cent reported victimization before arriving in the US. Those who had experienced victimization more often suffered from chronic conditions than people without such experiences: they were 32 per cent more likely to suffer from at least one chronic condition (p < 0.05), especially cancer (4.36, p < 0.05), arthritis (1.77, p < 0.01), and cardiovascular disease (odds ratio 1.32, p < 0.05). These relationships were in part mediated by differences in healthcare access after arriving in the US between those who had experienced victimization and those who had not. Victimization may have consequences for integration and later-life chronic disease.
A previous study discovered that two speakers with moderate apraxia of speech increased their sequential motion rates after unilateral forced-nostril breathing (UFNB) practiced as an adjunct to speech-language therapy in an AB repeated-measures design. The current study sought to: (1) delineate possible UFNB plus practice effects from practice effects alone in motor speech skills; (2) examine the relationships between UFNB integrity, participant-reported stress levels, and motor speech performance; and (3) sample a participant-led UFNB training schedule to contribute to the literature's growing understanding of UFNB dosage. A single-subject (n-of-1 trial), ABAB reversal design was used across four motor speech behaviors. A 60-year-old female with chronic, severe apraxia of speech participated. The researchers developed a breathing app to assess UFNB practice integrity and administer the Simple Aphasia Stress Scale after each UFNB session. The participant improved from overall severe to moderate apraxia of speech on the Apraxia Battery for Adults. Visual inspection of graphs confirmed robust motor speech practice effects for all variables. Articulatory-kinematic variables demonstrated sensitivity to the UFNB-plus-practice condition and correlated to stress scale scores but not UFNB integrity scores. The participant achieved 20-minute UFNB sessions 4 times per week. Removal of UFNB during A2 (UFNB withdrawal) and after a 10-day break during B2 (UFNB full dosage) revealed UFNB practice effects on stress scale scores. UFNB with motor speech practice may benefit articulatory-kinematic skills compared to motor speech practice alone. Regular, cumulative UFNB practice appeared to lower self-perceived stress levels. These findings, along with prior work, provide a foundation to further explore yoga breathing and its use with speakers who have apraxia of speech.
Raydiant Oximetry, Inc. is developing a novel and non-invasive fetal pulse oximetry device to fundamentally improve how fetuses are monitored during labor. The Raydiant Oximetry Sensing System (Lumerah) is a fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy. Lumerah performs its measurements without the requirement for transvaginal placement and its associated risks. Lumerah is intended as an adjunct to cardiotocography by detecting fetal oxygen deprivation which is both life-threatening to the fetus and can lead to the irreversibly debilitating consequences of newborn metabolic acidosis. The severe consequences associated with newborn metabolic acidosis and the lack of availability of an effective tool to support its early diagnosis led to the development of Lumerah.

In this study, women in labor will be simultaneously monitored with proven (previously FDA-approved) technology as a "ground truth". These women will be simultaneously monitored with both an external and internal oxygen sensor. Obstetric health-care providers are blinded to oximetry data presented by both devices; therefore, clinical decisions regarding interventions are made based on the standard factors, including cardiotocography. The primary efficacy analysis will be performed retrospectively by comparing data of fetal oxygenation displayed and recorded by both devices. Results of either the Lumerah external sensor or the internal sensor will not be used to guide or alter patient management.
PURPOSE: A supporter for retinal disorder treatment is provided to be applied to a treatment for ischemic retinal disorder by not having toxicity, and by the cell or neurotransmitter which reaches nerve fiber layer and ganglion cell layer after passing internal limiting membrane then differentiating. CONSTITUTION: A supporter for retinal disorder treatment comprises adult stem cell. The adult stem cell is loaded with a hydrogel type injection composition comprising biodegradable synthetic polymer and water for injection. The adult stem cell is loaded with a hydrogel type injection composition comprising biodegrading natural polymer, biodegradable synthetic polymer, alkalizer, and water for injection. The biodegrading natural polymer is more than one selected from a group comprising chitosan, hyaluronate, alginate, starch, pectin, dextran, flurane, and heparin. The biodegrading natural polymer is used in the concentration of 5.0 w/v%.
BACKGROUND: Progression of proximal or distal aortic dilatation is defined as reverse aortic remodeling after surgery for acute type A aortic dissection (ATAAD) that may be dependent on aortic wall degeneration.
METHODS: We investigated whether aortic wall degeneration is associated with reverse aortic remodeling leading to aortic reoperation after surgery for ATAAD. Altogether, 141 consecutive patients undergoing surgery for ATAAD at Tampere were evaluated. The resected ascending aortic wall at surgery was processed for 42 degenerative, atherosclerotic and inflammatory histological variables. Patients undergoing aortic reoperations (Redos) were compared with those without aortic reoperations (Controls) during a mean 4.9-year follow-up.
RESULTS: Redos were younger than Controls (56 and 66 years, respectively, P < 0.001), and had less frequently previous cardiac surgery prior to ATAAD. Initial surgery encompassed replacement of the ascending aorta in the majority. There were 21 Redos in which one patient died during follow-up as compared with 51 deaths in Controls (log Rank P = 0.002). Histology of the aortic wall revealed increased elastic fiber fragmentation, loss, and disorganization in Redos as compared with Controls (2.1 ± 0.5 vs. 1.9 ± 0.5, Point score unit (PSU), P = 0.043 and 1.7 ± 0.8 vs. 1.2 ± 0.8, PSU, P = 0.016, respectively). Moderate atherosclerosis occurred less often in Redos vs. Controls (9.5% vs. 33%, PSU, P = 0.037, respectively).
CONCLUSIONS: According to this exploratory study, histopathology reveals distinctive aortic wall degeneration during ATAAD. Reverse aortic remodeling after ATAAD is associated with the presence of ascending aortic wall elastic fiber fragmentation, loss and disorganization during ATAAD.
An active motion device (CAM) known as a CAMOPED was given after surgery. The device was used for 3 sessions of 20 minutes for 3 weeks.
1446141 Cinnamamides and hydrocinnamamides KISSEI YAKUHIN KOGYO KK 16 Jan 1974 [18 Jan 1973] 02102/74 Heading C2C The invention comprises cinnamamides and hydrocinnamimides of the Formula I wherein R 1  and R 2  each are H or C 1-4  alkyl; R 3  and R 4  are H or may be combined together to form another carbon to carbon bond; each X is OH, halogen, C 1-4  alkyl or C 1-4  alkoxy; and n is 1 to 3, or (X) n  may also constitute where a and b are 0 or 1 and c is 2 to 10 wherein the said group is attached to adjacent carbon atoms of the benzene ring to form a ring, and pharmaceutically acceptable salts thereof, and their preparation. The compounds are prepared by reacting the appropriate cinnamic acids or hydrocinnamic acids or reactive functional derivatives thereof with the corresponding aminobenzoic acids or esters thereof, and, if necessary, hydrolysing the resulting products. Compounds of the Formula I above in which R<SP>3</SP> and R<SP>4</SP> are combined together to form a carbon to carbon bond may also be prepared by halogenating hemi esters of malonic acid, reacting the resulting 2-(haloformyl)acetic acid esters with aminobenzoic acids or esters thereof, hydrolysing the resulting products, and condensing the resulting N-(carboxyphenyl)malonamic acids using the Knoevenogel reaction with benzaldehydes of the Formula X 4 - (4 - Acetoxycinnamoylamino)benzoic acid and 3 - (4 - acetoxy - 3 - methoxycinnamoylamino)benzoic acid are obtained by reacting the appropriate cinnamoyl chlorides with the corresponding aminobenzoic acids. Methyl N - (3,4 - dimethoxycinnamoyl)- anthranilate is prepared by reacting methyl anthranilate with 3,4-dimethoxycinnamic acid. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above acids or salts thereof in admixture with pharmaceutically acceptable carriers or diluents. The compounds possess antiallergic activity.
Six subjects in this cohort will receive a single dose of GSK3050002 0.5 mg and two subjects will receive a single dose of placebo intravenously. Sentinel subjects will be used in the cohort.
Participants will orally consume one capsule of Resveratrol following each of their main meals (i.e. breakfast, lunch, and dinner) totaling 1500 mg/day for 90 days.
A miniature implantable drug delivery capsule system. The drug delivery system ( 400 ) comprises one or more ball semiconductor aggregations ( 404 ) and ( 406 ) facilitating release of a drug stored in a reservoir ( 402 ). The first aggregate ( 404 ) is used for sensing and memory, and a second aggregation ( 406 ) for control aspects, such as for pumping and dispensing of the drug. Notably, the aggregates ( 404 ) and ( 406 ) may be interconnected by a common bus ( 410 ) for communication purposes, or may be implemented to operate independently of each other. Each aggregate ( 404 ) and ( 406 ) is encased in a semipermeable membrane ( 408 ) to allow species which are to be monitored, and drugs to be delivered, to freely diffuse. The system ( 400 ) may communicate with a remote control system, or operate independently on local power over a long period for delivery of the drug based upon a request of the patient, timed-release under control by the system ( 400 ), or delivery in accordance with measured markers.
The invention discloses a Chinese medicine paste for treating skin diseases and a preparation method thereof, which belong to the technical field of traditional Chinese medicines. The Chinese medicine paste for treating skin diseases comprises following raw materials in parts by weight: 5-20 parts of extractives of a component A, 80-200 parts of linden leaf powder, 80-200 parts of Chinese dodder powder, 80-200 parts of glycerin, 30-70 parts of wool grease, 10-40 parts of balsam oil and 50-100 parts of ginseng vanishing cream. The component A comprises raw materials of inus koraiensis branches, birch branches and poplar branches in the following weight ratio of 1: (1-4): (1-4). The components of the Chinese medicine paste for treating skin diseases are easy to obtain. The prepared Chinese medicine paste has favorable effects of moistening dry skin, relieving damp and hot and treating ichthyosis and xerodermia, and has a short treatment course. After the Chinese medicine paste is used, patients have favorable medicine tolerance. Before and after the use of the Chinese medicine paste, the liver-kidney functional index has no abnormity, and the hemogram has no obvious change.
The last five patients will receive transfusions of FFP to normalize INR. If the initial INR is between 2-4, then 2 units of FFP (Round 1) will be administered emergently. If the initial INR is \>4, then 4 units of FFP will be administered (Round 1). The INR will be checked after each round of FFP infusion completed. Once INR ≤1.3, then the INR will be again checked every 2 hours after normalization for 6 hours total and then 24 hours post-initial infusion. If the INR should ever return to \>1.3, then repeat infusions of FFP will begin as outlined above and the INR will be checked serially as defined above.
The prepn. of collagen sponges comprises subjecting conventionally pretreated crude material to alkali treatment, allowing the surface of the material to denature to such an extent that 3-6 wt. % of it (based on the total mass of the crude material) has been degraded to macromolecular peptides. The material is then subjected to acid treatment, washed, comminuted, frozen and freeze-dried. During freeze drying, the essentially already dry mateiral is subjected to a vacuum of 0.5-3.0 m bar at 110-150 deg.C. Pref. alkali treatment is carried out using 1-3 wt. % NaOH soln. over a period of 1-5 weeks. The comminuted material is frozen as an aq. dispersion at -10 to -30 deg.C for 0.5-4 hrs. and then stored for at least 24 hrs. at -3 to -5 deg.C. Prior to freezing, the comminuted material can be mixed with cosmetics or pharmaceuticals. The active ingredients are esp. ATP-charged liposomes or microencapsulated active ingredients which can be released on wetting with water. The material charged with active ingredient is given a water-impermeable coating on one side, after it has been freeze dried. USE/ADVANTAGE - The collagen sponge can be used for the transdermal application of pharmaceuticals and cosmetics and is esp. useful as a mask. The process gives stable collagen spring without adding chemical crosslinking agents, emulsifiers or preservatives