anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To maintain the activity of the antigen reacting specifically with a self antibody for a long period of time by treating the antigen which can react specifically with the self-antibody with an independent aq. soln. of 1 or >=2 kinds among a saccharide, chelate agent, egg white albumin, gelatin and 'Ficoll(R)' or a soln. mixture composed thereof and cow serum albumin in the stage of conjugating the antigen with an insoluble support. CONSTITUTION:The antigen is dissolved in a suitable solvent and is immersed together with the insoluble support in order to conjugate the antigen with the insoluble support. The isoluble support is pretreated with poly-L-lysine, methylated cow serum albumin, etc. The soln. of the antigen is removed after such immersion and the base is cleaned with physiological salt soln. by which the antigen-conjugated insoluble support is obtd. The insoluble support is then immersed into the independent aq. soln. of compd 1 or >=2 kinds selected from the grop consisting of the saccharide, chelate agent, egg white albumin, gelatin and 'Ficoll(R)' or the soln. mixture composed thereof and cow serum albumin and after the immersion, the aq. soln. is removed and the support is cleaned with the physiological salt soln, by which the stable solid phase reagent is obtd.
This study aimed to investigate the effects of high-dose inhaled corticosteroids (ICS) on chronic cough patients with elevated fractional exhaled nitric oxide (FeNO) levels. In a prospective study, adults with chronic cough and FeNO ≥ 25 ppb, without any other apparent etiology, received fluticasone furoate (200 mcg) for three weeks. Outcomes were evaluated using FeNO levels, cough severity, and Leicester Cough Questionnaire (LCQ) before and after treatment. Of the fifty participants (average age: 58.4 years; 58% female), the treatment responder rate (≥ 1.3-point increase in LCQ) was 68%, with a significant improvement in cough and LCQ scores and FeNO levels post-treatment. However, improvements in cough did not significantly correlate with changes in FeNO levels. These findings support the guideline recommendations for a short-term ICS trial in adults with chronic cough and elevated FeNO levels, but the lack of correlations between FeNO levels and cough raises questions about their direct mechanistic link.
Inflammatory epithelial diseases are spurred by the concomitant dysregulation of immune and epithelial cells. How these two dysregulated cellular compartments simultaneously sustain their heightened metabolic demands is unclear. Single-cell and spatial transcriptomics (ST), along with immunofluorescence, revealed that hypoxia-inducible factor 1α (HIF1α), downstream of IL-17 signaling, drove psoriatic epithelial remodeling. Blocking HIF1α in human psoriatic lesions ex vivo impaired glycolysis and phenocopied anti-IL-17 therapy. In a murine model of skin inflammation, epidermal-specific loss of HIF1α or its target gene, glucose transporter 1, ameliorated epidermal, immune, vascular, and neuronal pathology. Mechanistically, glycolysis autonomously fueled epithelial pathology and enhanced lactate production, which augmented the γδ T17 cell response. RORγt-driven genetic deletion or pharmacological inhibition of either lactate-producing enzymes or lactate transporters attenuated epithelial pathology and IL-17A expression in vivo. Our findings identify a metabolic hierarchy between epithelial and immune compartments and the consequent coordination of metabolic processes that sustain inflammatory disease.
PROBLEM TO BE SOLVED: To provide a smart refrigerator capable of causing a user to manage food materials in a refrigerator and providing functions for recipe analysis and an online food materials order.SOLUTION: A smart refrigerator 100 comprises a user interface, a recipe management module, a storage management module and an order management module. The user interface causes the user to input an order instruction. The recipe management module stores a plurality of pieces of recipe information in which a plurality of pieces of necessary food material information are recorded, and the user can select the recipe information. The storage management module applies to an input of the food material information and stores the food material information. The order management module receives and stores at least one piece of order information. The recipe management module transmits the selected recipe information to the storage management module and it is compared with the stored food material information and analyzed, and the order information is generated. The order instruction is input into the user interface, and the order management module transmits the order information to a cloud server.SELECTED DRAWING: Figure 2
1. Technical Result Increase in efficiency of exposure of bacteria causing disease "black stalk" and soft putrefaction, extermination of development and propagation of the disease and widening of assortment of means for biological control. 2. Essence A means comprises a mixture of specific polyvalent bacteria Erwinia carotovora subsp. carotovora and Erwinia carotovora subsp. atroseptica in a proportion 1:1. 3. Field of Application Agriculture, environmental protection.
The invention discloses a reconstruction pill for treating hemiplegia and restoring consciousness, and a preparation method thereof. The traditional Chinese medicine composition comprises fineleaf schizonepeta herb, himalayan teasel roots, common four-o'clock roots, Chinese honeylocust fruit, common jasminorange, pine nodular branches, stem of oriental bittersweet and radix glycyrrhizae. The traditional Chinese medicine composition can be prepared into any clinically-acceptable oral pharmaceutical preparation according to the conventional traditional Chinese medicine preparation method. The traditional Chinese medicine composition made of the traditional Chinese medicines has the efficacy of dredging collaterals and recovering hemiplegia, dispelling wind and resolving phlegm, tonifying kidney and reinforcing tendon, reinforcing qi and nourishing blood, and resolving hard lump. Clinical curative effect observation verifies that the traditional Chinese medicine composition disclosed by the invention can be used for comprehensively treating apoplexy hemiplegia symptoms such as hemiplegia, facial paralysis, numbness of limbs and the like, which are caused by apoplexy, and the curative effect is accurate, reliable and real. The traditional Chinese medicine composition is non-poisonous and harmless, safe and reliable, has no any side effect after being taken, and is safe in clinical use.
BACKGROUND: As global aging accelerates, routinely assessing the functional status and morbidity burden of older patients becomes paramount. The aim of this study is to assess the validity of the comprehensive clinical and functional Health Assessment Tool (HAT) based on four cohorts of older adults (60 + years) from the Swedish National study on Aging and Care (SNAC) spanning urban, suburban, and rural areas.
METHODS: The HAT integrates five health indicators (gait speed, global cognition, number of chronic diseases, and basic and instrumental activities of daily living), providing an individual-level score between 0 and 10. The tool was constructed using nominal response models, first separately for each cohort and then in a harmonized dataset. Outcomes included all-cause mortality over a maximum follow-up of 16 years and unplanned hospital admissions over a maximum of 3 years of follow-up. The predictive capacity was assessed through the area under the curve (AUC) using logistic regressions. For time to death, Cox regressions were performed, and Harrell's C-indices were reported. Results from the four cohorts were pooled using individual participant data meta-analysis and compared with those from the harmonized dataset.
RESULTS: The HAT demonstrated high predictive capacity across all cohorts as well as in the harmonized dataset. In the harmonized dataset, the AUC was 0.84 (95% CI 0.81-0.87) for 1-year mortality, 0.81 (95% CI 0.80-0.83) for 3-year mortality, 0.80 (95% CI 0.79-0.82) for 5-year mortality, 0.69 (95% CI 0.67-0.70) for 1-year unplanned admissions, and 0.69 (95% CI 0.68-0.70) for 3-year unplanned admissions. The Harrell's C for time-to-death throughout 16 years of follow-up was 0.75 (95% CI 0.74-0.75).
CONCLUSIONS: The HAT is a highly predictive, clinically intuitive, and externally valid instrument with potential for better addressing older adults' health needs and optimizing risk stratification at the population level.
Quantitative evidence synthesis methods aim to combine data from multiple medical trials to infer relative effects of different interventions. A challenge arises when trials report continuous outcomes on different measurement scales. To include all evidence in one coherent analysis, we require methods to "map" the outcomes onto a single scale. This is particularly challenging when trials report aggregate rather than individual data. We are motivated by a meta-analysis of interventions to prevent obesity in children. Trials report aggregate measurements of body mass index (BMI) either expressed as raw values or standardized for age and sex. We develop three methods for mapping between aggregate BMI data using known or estimated relationships between measurements on different scales at the individual level. The first is an analytical method based on the mathematical definitions of z-scores and percentiles. The other two approaches involve sampling individual participant data on which to perform the conversions. One method is a straightforward sampling routine, while the other involves optimization with respect to the reported outcomes. In contrast to the analytical approach, these methods also have wider applicability for mapping between any pair of measurement scales with known or estimable individual-level relationships. We verify and contrast our methods using simulation studies and trials from our data set which report outcomes on multiple scales. We find that all methods recreate mean values with reasonable accuracy, but for standard deviations, optimization outperforms the other methods. However, the optimization method is more likely to underestimate standard deviations and is vulnerable to non-convergence.
PURPOSE:To adsorb and remove malodorous components while well maintaining a hygienic state by depositing deodorant particles. on an org. high-polymer material matrix. CONSTITUTION:The calcium phosphate compd. to be used as a deodorant is made into the particles which have 1.0 to 2.0Ca/P ratio, are in the form of granules or porous granules and have 0.1 to 2000mum grain size and 0.1 to 100m<2>/g specific surface area. Such deodorant is deposited on paper, gauze, nonwoven fabric or plastic foam as the org. high-polymer material matrix.
NEW MATERIAL:A compound of formula I (A is lower alkylene; M is H, an atom or group thereof giving a monovalent cation or 1/pmole of an atom or mixture thereof giving a p-valent cation; n is 1-3). EXAMPLE:A thermal neutron-capturing agent. Especially useful for monoclonal antibody method. USE:An ammonium group is introduced into sodium dodecahydrododecaborate of formula II to give sodium ammonio-undecahydrododecaborate of formula III. The compound of formula III is subjected to a sodium halide-removing reaction with a halogenated alkanoic acid ester of a formula X-A-COOR (X is halogen such as Cl or Br; R is lower alkyl) such as methyl chloroacetate. The ester bond of the reaction product is hydrolyzed under a week alkaline condition.
The invention belongs to traditional Chinese medicinal preparations, and provides a convenient and effective way for treating renal carcinoma on the basis of traditional Chinese medicine. The renal carcinoma always causes endless pain to patients and even can mercilessly kill the patients. In western medicine, the focus of the renal carcinoma is removed through operations, which always causes relatively serious wound to the patients and high medical expenses, and the patients cannot afford. Based upon researches and and practices for years, a decoction preparation for treating the renal carcinoma is researched; therefore, good news is brought for patients with the renal carcinoma. A medicinal prescription consists of the following components: 15g of concha ostreae, 12g of pangolin scales, 6g of scorpio, 6g of pericarpium citri reticulatae viride, 4.5g of radix aucklandiae, 9g of trogopterus dung, 9g of peach kernel and 9g of apricot kernel, and in addition, 12g of turtle shells are decocted in the form of pills (for swallowing). A preparing method comprises the following steps: preparing the medicinal materials in accordance with the prescription, decocting the medicinal materials in water, and cooling an obtained decoction, so that two decoction preparations are prepared. A taking method comprises the following steps: taking the decoction preparation twice every day, one decoction preparation per time. The prescription, on treating the renal carcinoma, has achieved a good curative effect.
The invention discloses a probiotic fermented unprocessed common monkshood daughter root composition and a preparation method thereof. Unprocessed common monkshood daughter roots are smashed, water is added for soaking, pH is adjusted, enzymolysis and sterilization are carried out, the sterilized solution is inoculated with a precultured culture, fermentation is carried out, and then the probiotic fermented unprocessed common monkshood daughter root composition is obtained. The invention further discloses application of the probiotic fermented common monkshood daughter root composition to preparation of fermented type common monkshood daughter root Chinese medicinal granules and to extraction separation of polysaccharide and an alkaloid composition in fermented common monkshood daughter roots. The prepared fermented type common monkshood daughter root Chinese medicinal granules can remarkably reduce the content of toxic component diester-alkaloids, increase the content of medicinal component single ester type alkaloids, promote extraction of medicinal components to the greatest extent and increase the utilization ratio of drug, and is stable in component and convenient to use. Experiment results show that the content of high-toxicity diester-alkaloids in the fermented type common monkshood daughter root Chinese medicinal granules is very low, almost no diester-alkaloids is detected, and the content of the low-toxicity single ester type alkaloids is remarkably increased. Acute toxicity tests show that the fermented type common monkshood daughter root Chinese medicinal granules do not show toxicity.
Prepns. for preventing sunburn contain a local anaesthetic in a concn. below that at which it exhibits anaesthetic action. The prepns. can be applied during or after exposure to the sun, before the onset of erythema; the local anaesthetics, which need not be of the type normally used topically, are used at doses far below the toxic dose. The local anaesthetic is suitably the site, falicaine, pramoxine, procaine or its salts, diperodone hydrochloride, lidocaine, dibucamine hydrochloride, fenocaine hydrochloride or acoine. The concn. is pref. 10-50% of the dose normally used for anaesthetic purposes. The prepns. are pref. formulated as ointments, emulsions or oil-based solns.
Restenosis remains a frequent cause of late failure following successful coronary angioplasty occurring in an estimated 20-40% of procedures performed. Coronary stents provide mechanical scaffolding that helps reduce restenosis by limiting the extent of elastic recoil and late vascular remodeling. Despite improvements over balloon angioplasty alone, restenosis following coronary stenting procedures has been cited to occur in 20-40% of cases and is primarily a result of neointimal hyperplasia. Thus, stents which are capable of delivering drugs to limit neointimal hyperplasia, in addition to providing mechanical support at the area of the lesion, have been developed to further limit the extent of restenosis following coronary stenting. There are several pharmacologic agents approved for use with drug-eluting stents.Two drugs have been widely studied in controlled clinical trials and real-world patient populations, sirolimus and paclitaxel.

This study will evaluate a new sirolimus-eluting cobalt chromium coronary stent system compared to an approved paclitaxel-eluting coronary stent system in the treatment of single de novo coronary lesions in native coronary arteries. Subjects meeting qualification will be randomized in a 1:1 fashion to treatment with the Conor sirolimus-eluting coronary stent or to treatment with an approved paclitaxel-eluting coronary stent. All subjects will undergo angiographic follow-up at six months and complete clinical follow-up for a period of five years.
PURPOSE:To obtain the subject agent which enables a polymeric resin material to durably adhere to a metal, even when the metal is noble or base one, by dissolving a plurality of specific polymerizable monomers in an organic solvent in prescribed amounts. CONSTITUTION:This treating agent is obtained by dissolving in an organic solvent (e.g. methyl methacrylate/acetone) 0.001-10wt.% polymerizable monomer having a thiophosphoric acid chloride group (e.g. 10- methacryloyloxydecylthiophosphoric acid dichloride) and 0.001-10wt.% polymerizable monomer having a phosphoric ester group (e.g. 10- methacryloyloxydecylphosphoric ester) preferably together with 0.1-5wt.% polymerization initiator (e.g. benzoyl peroxide).
Providers randomized to routine care will not be trained on the FHA or DCA or the completion of the checklists. All EMTs in both groups (Transport Plus and standard education), will be asked to answer some demographic questions and will be trained to collect responses to 3questions commonly used to assess a patient's risk of falling and to collect best contact information for phone follow up from patients or their caregivers and to obtain permission for a follow-up phone call from research personnel.
RA is one of the main disabling diseases in nowadays, which is an autoimmune disease with complex networks mechanism involving multiple signaling pathways and existing cross path. The investigators consider that the "heat-dampness and blood stasis" syndrome is the main syndrome and major pathogenesis for active RA, which on the base of the theory of traditional Chinese medicine and a large quantity of clinical practice, and also examined by mechanism experiments. But the material basis of this syndrome is remained unclear, lack of high specific objective basis to ensure the syndrome differentiation consistency accurately in clinical practice. Proteomic techniques study cells or the body by all the protein expression and function, thus has the potential efficient for decoding syndrome biological basis. Proteomic techniques are the most effective way to reveal the essence of TCM syndrome. The investigators will use proteomic technology to explore the protein markers and to applicate those protein markers in syndrome diagnosis of hot-dampness and blood stasis syndrome in patients with RA. With strong clinical applicability, this will reveal the scientific connotation of this syndrome, preliminarily guide the syndrome differentiation.
PURPOSE:To obtain interferon (IF) as an antiviral agent, antitumor agent, cell prolification inhibitor and immunosuppressant in high yield, by cultivating a microorganism having a developing vector in which a gene capable of producing IF incorporated therein in a specific synthetic culture medium. CONSTITUTION:A microorganism having a developing vector having a gene capable of producing interferon (IF), e.g. human leukocytic IF gene, human immunological IF gene, etc. incorporated therein is cultivated in a synthetic culture medium containing preferably 0.1-10g/l L-glutamic acid and preferably 10<-5>-10<-3>mol/l iron ion source preferably at 5-7.5 culture medium pH and 20- 42 deg.C for 3-72hr. IF is then collected from the resultant culture. Preferably, a Zn ion source and a Cu ion source in an amount of respectively 10<-5>-10<-3>mol/l are added to the culture medium.
This study investigated the antinociceptive potential of cannabidiol (CBD) in male and female Wistar rats. The assessment and analysis included tail withdrawal to thermal stimulation (tail flick test) and mechanical allodynia induced by plantar incision injury (von Frey test). CBD reduced acute thermal sensitivity in uninjured animals and post-operative mechanical allodynia in males and females. In the tail flick test, CBD 30 mg/kg i.p. was required to induce antinociception in males. During the proestrus phase, females did not show a statistically significant antinociceptive response to CBD treatment despite a noticeable trend. In contrast, in a separate group of rats tested during the late diestrus phase, antinociception varied with CBD dosage and time. In the post-operative pain model, CBD at 3 mg/kg decreased mechanical allodynia in males. Similarly, this dose reduced allodynia in females during proestrus. However, in females during late diestrus, the lower dose of CBD (0.3 mg/kg) reduced mechanical allodynia, although the latency to onset of the effect was slower (90 min). The effectiveness of a 10-fold lower dose of CBD during the late diestrus stage in females suggests that ovarian hormones can influence the action of CBD. While CBD has potential for alleviating pain in humans, personalized dosing regimens may need to be developed to treat pain in women.
The present invention provides a system for constructing eye age prediction and its method. The system includes a database, a deep learning module and a test/verification module. The deep learning module and the test/verification module are electrically connected to the database. The database includes original data, and the original data is grouped into a training model, a testing model and a verification model. The deep learning module performs a training setting based on the training model. The test/verification module performs a test setting based on the training setting and the test model. The test/verification module performs a verification setting based on the test setting and the verification model.
PURPOSE: To obtain an emulsified composition containing an alkyl-modified carboxyvinyl polymer and a saccharide, excellent in usability with dampishness and body even without any surfactant. CONSTITUTION: This composition contains 0.01-10wt.% of an alkyl-modified carboxyvinyl polymer (e.g. acrylic and methacrylic alkyl ester copolymer, trade name: PEMULEN-TR-1) and 0.1-30wt.% of a saccharide (e.g. sorbitol). Besides, this composition is formulated, according as appropriate, with various ingredients used conventionally in cosmetics, such as oil-and-fat, lower alcohol, humectant, water-soluble polymer, ultraviolet absorber, metallic ion-blocking agent, neutralizing agent, pH adjuster, antimicrobial agent, medicinal agent, extract, perfume, coloring matter, etc. The oil phase component of the above ingredients is added to the aqueous phase component, and concurrently, the whole system is emulsified by a relevant machine, thus affording the final objective emulsified composition.