anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: This study aimed to determine the factors that contribute to the failure of bowel preparation in patients undergoing colonoscopy and to develop a risk prediction model.
METHODS: A total of 1115 outpatients were included. Patients were randomly divided into two groups: the modeling group (669 patients) and the validation group (446 patients). In the modeling group, patients were further divided into two groups based on their success and failure in bowel preparation using the Boston Bowel Preparation Scale. A logistic regression analysis model was used to determine the risk factors of bowel preparation failure, which was subsequently visualized using an alignment diagram.
RESULTS: After controlling for relevant confounders, multifactorial logistic regression results showed that age ≥ 60 years (OR = 2.246), male (OR = 2.449), body mass index ≥ 24 (OR = 2.311), smoking (OR = 2.467), chronic constipation (OR = 5.199), diabetes mellitus (OR = 5.396) and history of colorectal surgery (OR = 5.170) were influencing factors of bowel preparation failure. The area under the ROC curve was 0.732 in the modeling group and 0.713 in the validation group. According to the calibration plot, the predictive effect of the model and the actual results were in good agreement.
CONCLUSIONS: Age ≥ 60 years, male, body mass index ≥ 24, smoking, chronic constipation, diabetes mellitus, and history of colorectal surgery are independent risk factors for bowel preparation failure. The established prediction model has a good predictive efficacy and can be used as a simple and effective tool for screening patients at high risk for bowel preparation failure.
The self-control treatment group will wear a Fitbit step counter across 8 weeks. In addition, they will use the MindHike smartphone application across 8 weeks. Each day, the app sends the a reminder to wear the Fitbit as well as a short interventional input targeting self-control.
PURPOSE:To provide a rinse-type hair cosmetic containing aqueous decoction of raw hibiscus leaf as a main component, usable safely without stimulating nor damaging the skin and hair, giving beautifully finished hair having improved moistness and luster, and useful for the treatment of hair and skin. CONSTITUTION:The raw leaves of hibiscus are crushed and decocted with water, e.g. by stirring in water, and the obtained viscous liquid is used as a main component of the objective cosmetic. Whipped albumen is added to the decocted viscous liquid, and the mixture is boiled and filtered with a proper filtration apparatus to remove fibrous material and obtain a boiled decoction containing mucous components such as mucoprotein, glucoside, etc. The decoction is added with an adjuvant such as a humectant, emollient, etc., (e.g. glycerol) and a preservative such as sodium benzoate, boiled, cooled, and added with a vegetable perfume to obtain a hair rinse having higher stability and purity. EFFECT:Since the cosmetic is free from surfactant in contrast with conventional hair rinse, the cosmetic can be used even to the scalp having wound, inflammation, eczema, etc.
Vitiligo is the most common depigmentation disorder. A commonly used treatment is phototherapy with narrow-band ultraviolet B irradiation (NB-UVB). Further therapeutic approaches are desired and currently being evaluated. The investigational product, afamelanotide, is a synthetic analogue of the human alpha melanocyte stimulating hormone (alpha-MSH). Afamelanotide activates melanin in skin, with the controlled-release injectable implant formulation having an affect across the total body surface area (pandermally). Earlier studies in vitiligo patients showed afamelanotide, in combination with NB-UVB, could induce faster and deeper repigmentation in patients compared to NB-UVB alone.
BACKGROUND: Calculating the immersion time at sea of human skeletal remains is a challenge for forensic investigations and the answer to this question would solve many court cases in the shortest possible time. Remains in water create profound structural changes due to countless variables that lead to difficulties in interpretation during investigations.
CASE REPORT: In this paper, two forensic cases found at sea were analysed, Case A, an extensively skeletonised corpse, and Case B, an isolated, intact foot with soft tissue, both found only 9 km away from the shores of the Tyrrhenian Sea (Southern Italy). A preliminary radiodiagnostic examination was performed for both cases. Subsequently, macroscopic observation of two tattoos found on case A was carried out. Autopsy examination was then carried out with subsequent anthropometric analysis to reconstruct the biological profile of both subjects, (case A) and (case B). Finally, histological and genetic analyses were performed.
CONCLUSIONS: The examinations carried out made it possible to determine two compatible biological profiles, despite the taphonomic difference, and these examinations were corroborated by the anthropometric and genetic correlation, which led to the solution of a single judicial case. In conclusion, all the investigations carried out made it possible to state that the skeletonised corpse (Case A) and the isolated foot (Case B) belonged to the same individual in life. This result made it possible to identify the victim, thus establishing the profile of an individual who had disappeared in the previous two months due to a shipwreck.
A prospective observational study will be performed at the University Medical Center Groningen, the Netherlands using longitudinal data collection. The design of the study will be that patients starting on posaconazole treatment will be evaluated. After informed consent is obtained medical data will be collected from the medical chart. Posaconazole plasma concentration (trough levels) and inflammatory markers (e.g. C-reactive protein) will be determined in all samples available from routine analysis (often daily). This will result in a detailed data set capturing day to day variations in inflammation and drug concentrations.
5-Aminoacridine salts are prepared by dissolving 5-aminoacridine in an organic solvent, e.g. alcohol or acetone, and the resulting solution is reacted with one or more acids. Suitable acids specified are aliphatic carboxylic acids, mono or polysubstituted aliphatic acids, the substituents may be chlorine, bromine, iodine or hydroxy, aromatic carboxylic acids, the neuclus being derived for example from benzene, naphthalene or anthracene, substituted or polysubstituted aromatic acids, the substituents being for example chlorine, bromine, iodine, methoxy, methyl, hydroxyl, methyl or carboxyl, an aromatic mono- or polysulphonic acid, which may contain any of the above substituents, and an inorganic acid containing phosphorus or boron. In examples, 5-aminoacridine salts are prepared from salicylic, acetic, tartaric, sulphuric and oxalic acids. ALSO:An antiseptic eye lotion is obtained by dissolving one or more salts of 5-aminoacridine in water and adding an aqueous solution of boric acid and borax to bring the pH of the solution to between 5 and 8.5.  Further ingredients that may be added are zinc sulphate, chlorbutol, sodium chloride, distilled witch hazel extract and sambuci water.  A number of suitable types of acids from which the 5-aminoacridine salt may be derived are given.  In the examples, the 5-aminoacridine salts are derived from salicylic, acetic, tartaric, oxalic and sulphuric acids.
The intervention group carried out a program for 24 weeks. The participant had to perform the program 3 days per week for 12-15' each day (training days with the team, prior to group activation).
1287343 N-Carbamoylethyl aromatic amine compounds AMERICAN CYANAMID CO 4 Aug 1970 37677/70 Heading C4P [Also in Division C2] The invention comprises dyes having the general formula wherein Ar is benzene, biphenyl, or naphthalene; R 1  is 2-carbamoylethyl amino or bis-(2-carbamoylethyl amino); R 2  is amino, nitro, hydroxy or R 1 ; and R 3  is hydrogen, halogen, alkyl, alkoxy, amino, nitro or R 1 . The compounds are prepared by various methods, e.g. by reacting an aromatic amine or nitroamine with acrylamide in acetic acid at 50-120‹ C., to replace one or more of the amino hydrogen atoms with a carbamoylethyl group; by reacting an aromatic nitroamine with acrylamide at 25-145‹ C. in a non-polar non-hydroxylated solvent in the presence of a basic catalyst to give a product having a nitro group and at least one propionamide group, or by reacting a halo substituted aromatic compound with amino propionamide in an alkanol. Preferably the groups R 1  and R 2  are ortho or para to each other. The compounds of Formula I may also be used as intermediates in the synthesis of dyes, e.g. by diazotizing compounds containing an amino group and coupling with a coupling component. The compounds of Formula I and their derivatives are used for dyeing keratinaceous fibres particularly hair, with or without other colour modifiers and additives.
This study represents a unique opportunity to improve access to treatments for urine leakage for women Veterans. This research study will examine the effects of two mobile health technologies on improving bladder symptoms, as part of a randomized clinical trial. The study includes 260 women Veterans recruited from 3 sites: the Birmingham VAMC, the Atlanta VAHCS, and the Durham VAMC (86 per site). Women will receive first-line treatments for urine leakage through randomization to one of two delivery methods for direct treatment: (1) a web-based mobile health application that delivers content daily for 8 weeks compared to (2) a single video session delivered by VA Video Connect. At 8-weeks, women who do not have improved symptoms will have the ability to continue the treatment or receive an initial or booster video session. The investigators will measure bladder symptoms (3 questions by self-report over the phone or via survey) at baseline, 8-weeks, 12-weeks, and 6-months. Additionally, the investigators will interview 54 women Veterans and 12 providers to learn about their experiences with the technologies using 1:1 telephone interviews at 12-weeks. The findings from this study will inform the best technology to improve access for bladder leakage among women Veterans across a wider array of VHA facilities.
The participants were randomly assigned in a 2:1 ratio to Cohort 1a in a blinded fashion to receive either a single dose of ALXN1210 SC 400 mg or single dose of placebo SC. The Safety Review Committee (SRC) evaluated the first 48 hours of postdose clinical safety data for participants in Cohort 1a to determine if enrollment into Cohorts 1b or 2 could begin. Following the SRC review, participants were randomly assigned in a 2:1 ratio to either Cohort 1b or Cohort 2. Within Cohort 1b, participants were blinded and further randomly assigned in a 5:1 ratio to receive either a single dose of ALXN1210 SC 400 mg or a single dose of placebo SC, respectively. The participants in Cohort 2 received a single dose of ALXN1210 IV 400 mg in an open-label fashion. Safety, PK, PD, and immunogenicity assessments were performed on the follow-up period after the last dose.
Genetic variants associated with developmental and epileptic encephalopathies have been identified in the GABRB3 gene that encodes the β3 subunit of GABAA receptors. Typically, variants alter receptor sensitivity to GABA resulting in either gain- or loss-of-function, which correlates with patient phenotypes. However, it is unclear how another important receptor property, desensitization, contributes to the greater clinical severity of gain-of-function variants. Desensitization properties of 20 gain-of-function GABRB3 variant receptors were evaluated using two-electrode voltage-clamp electrophysiology. The parameters measured included current decay rates and steady-state currents. Selected variants with increased or reduced desensitization were also evaluated using whole-cell electrophysiology in transfected mammalian cell lines. Of the 20 gain-of-function variants assessed, 13 were found to alter receptor desensitization properties. Seven variants reduced desensitization at equilibrium, which acts to worsen gain-of-function traits. Six variants accelerated current decay kinetics, which limits gain-of-function traits. All affected patients displayed severe clinical phenotypes with intellectual disability and difficult-to-treat epilepsy. Nevertheless, variants that reduced desensitization at equilibrium were associated with more severe clinical outcomes. This included younger age of first seizure onset (median 0.5 months), movement disorders (dystonia and dyskinesia), epilepsy of infancy with migrating focal seizures (EIMFS) and risk of early mortality. Variants that accelerated current decay kinetics were associated with slightly milder phenotypes with later seizure onset (median 4 months), unclassifiable developmental and epileptic encephalopathies or Lennox-Gastaut syndrome and no movement disorders. Our study reveals that gain-of-function GABRB3 variants can increase or decrease receptor desensitization properties and that there is a correlation with the degree of disease severity. Variants that reduced the desensitization at equilibrium were clustered in the transmembrane regions that constitute the channel pore and correlated with greater disease severity, while variants that accelerated current decay were clustered in the coupling loops responsible for receptor activation and correlated with lesser severity.
PROBLEM TO BE SOLVED: To obtain a natural antioxidant containing an extract from a specific plant as active ingredient, exhibiting its efficacy in preventing skin lipids from oxidation, skin damage due to oxidation, and also in preventing the skin from aging through its formulation in cosmetics, etc. SOLUTION: This antioxidant contains an extract from a plant belonging to the family Caesalpinia sepiaria (pref. Caesalpinia sappan, Caesalpinia echinata, Caesalpinia spinosa). For the extract, any part of the plant such as flowers, fruits, leaves, twigs, core materials, barks or roots, may be used. The amount of the antioxidant to be formulated in e.g. a cosmetic is normally 0.00001-5.0 (pref. 0.00005-2.0)wt.% on a dry basis. Appropriate use of this antioxidant affords cosmetics, etc., excellent in safety and stable to oxidation.
Within the scope of the research, individuals with chronic non-specific low back pain will be randomized and divided into two separate groups. Lumbar stabilization exercises will be applied to the control group twice a week for 6 weeks. Exercise duration, frequency, number and variety will be kept equal for the experimental and control groups. Demographic information of the patients, viscoelastic properties of the lumbar region, pain, function, quality of life, lower extremity muscle strength, endurance, balance and proprioception will be evaluated. Measurements will be made before treatment and at the end of 6 weeks of treatment.
FIELD: medicine. ^ SUBSTANCE: invention refers to microbiology and biotechnology. A method involves assessment of a prepared series of any live chicken cholera vaccine for harmlessness and immunogenicity from the perspective of repetition of a natural mechanism of micro- and microorganism interaction and a special role of environmental conditions. Birds of any species of body weight about 2 kg are vaccinated, and further they are infected on nasal and oropharyngeal mucosa at admissible optimal environmental temperature 20-22C. A series of the live vaccine is considered to be harmless if all single vaccinated birds with twice standard dose are permanently clinically healthy, and to be immunogenic if a survival rate after infection with a lethal dose of a standardised control Pasteurella in a capsular version of a microbial cell is at least 8 (80 %) specifically resistant birds of the 10 twice vaccinated birds (every 7 days, in a standard dose, in 10 days after immunisation), and a death rate is at least 8 (80 %) amenable birds of the 10 not vaccinated (control) birds. ^ EFFECT: improved efficiency of the method. ^ 7 dwg, 2 ex
Background: Early onset schizophrenia (EOS) involves positives symptoms such as psychotic behaviors, as well as negative symptoms such as disruptions to normal emotions and behaviors. Antipsychotics are the primary method of treatment in pediatric populations, but can produce unpleasant or dangerous side effects. Medication response is highly variable. Recent evidence demonstrates transcranial Direct Current Stimulation (tDCS) relieving auditory hallucinations (AH) associated with schizophrenia in adults, and to a lesser degree negative and cognitive symptomology. Such studies provide important scientific and technical knowledge that may be applied to pediatric populations.

Hypothesis: 1. Primary: Youths with EOS will demonstrate amelioration of AH after administration of tDCS. 2. TDCS will be well-tolerated in pediatric populations with minimal adverse side effects.
BACKGROUND: Several studies demonstrate that both external oblique ıntercostal block (EOIB) and modified thoracoabdominal nerves block through perichondrial approach (M-TAPA) contribute to analgesia in the anterior abdomen by targeting the thoracoabdominal nerves through distinct pathways. However, the sensory assessment and dermatomal analysis remain poorly understood.
METHODS: This prospective observational study aimed to determine the sensory assessment and dermatomal regression rate of EOIB and M-TAPA in patients undergoing laparoscopic cholecystectomy. The study included a total of 24 patients, with 12 patients in each group. Blocks were performed bilaterally, administering 25 mL of bupivacaine 0.25% for each side, resulting in a total volume of 50 mL. The anterior abdominal wall was vertically partitioned into the midabdomen, left-lateral abdomen, and right-lateral abdomen, and horizontally divided into the epigastric, umbilical, and hypogastric regions. Sensory block was assessed at the 45th minute with cold stimulus and pinprick. Subsequent evaluations were at intervals of 6, 10, 14, 18, 22, and 24 hours.
RESULTS: The blocked area percentile with cold sensation in the anterior abdomen was 43.07% (36.67-55.74) with EOIB, 40.49% (34.05-43.67) with M-TAPA (P=0.3219). When the region above the intertubercular plane was examined with cold sensation, EOIB covered 55.92% (46.75-62.07), and M-TAPA covered 49.60% (40.39-54.03) of the epigastric and umbilical areas. Assessment of the midabdominal portion of the anterior abdomen revealed that the blocked area percentile was statistically significantly higher in the M-TAPA group with both cold sensation and pinprick. At 45 minutes, the percentage of blocked dermatomes was 100% between T7-T8 in the EOIB group and between T7-T10 in the M-TAPA group. Both groups exhibited lower success rates in dermatomes T5 and T12, with no sensory block within the L1 dermatome, and cutaneous dermatomal block status either absent or negligible after 24 hours. All trocar entries were located within the cutaneous sensory block for both blocks, except for trocar C, which was located most laterally.
CONCLUSIONS: Bilateral EOIB and M-TAPA produce a comparable sensory cutaneous block in the anterior abdomen, particularly in the umbilical and epigastric regions. Additionally, the midabdominal cutaneous blocked area was greater in patients undergoing M-TAPA, suggesting a more consistent distribution along the anterior cutaneous branches of the thoracoabdominal nerves.
BACKGROUND: Surveillance of nondysplastic Barrett's esophagus (NDBE) is recommended to identify progression to dysplasia; however, the most cost-effective strategy remains unclear. Mutation of TP53 or aberrant expression of p53 have been associated with the development of dysplasia in BE. We sought to determine if surveillance intervals for BE could be stratified based on p53 expression.
METHODS: A Markov model was developed for NDBE. Patients with NDBE underwent p53 immunohistochemistry (IHC) and those with abnormal p53 expression underwent surveillance endoscopy at 1 year, while patients with normal p53 expression underwent surveillance in 3 years. Patients with dysplasia underwent endoscopic therapy and surveillance.
RESULTS: On base-case analysis, the strategy of stratifying surveillance based on abnormal p53 IHC was cost-effective relative to conventional surveillance and a natural history model, with an incremental cost-effectiveness ratio (ICER) of $8258 for p53 IHC-based surveillance. Both the conventional and p53-stratified surveillance strategies dominated the natural history model. On probabilistic sensitivity analysis, the p53 IHC strategy ($28 652; 16.78 quality-adjusted life years [QALYs]) was more cost-effective than conventional surveillance ($25 679; 16.17 QALYs) with a net monetary benefit of $306 873 compared with conventional surveillance ($297 642), with an ICER <$50 000 in 96% of iterations. The p53-stratification strategy was associated with a 14% reduction in the overall endoscopy burden and a 59% increase in dysplasia detection.
CONCLUSION: A surveillance strategy for BE based on abnormal p53 IHC is cost-effective relative to a conventional surveillance strategy and is likely to be associated with higher rates of dysplasia diagnosis.
<P>PROBLEM TO BE SOLVED: To provide a wiper as one which is impregnated with a chlorine dioxide solution by which the antiseptic effect and disinfecting effect of chlorine dioxide is hardly reduced.  <P>SOLUTION: In the wiper constituted by impregnating the same with the chlorine dioxide solution, the base material of the wiper mainly contains (50% by mass or more of) cellulosic fibers such as of cotton or rayon. Thereby a high chlorine dioxide concentration can be maintained over a long period. Further the deterioration of the wiper itself does not proceed in a certain degree. The wiper can be used for a cleaning and wiping article.  <P>COPYRIGHT: (C)2010,JPO&INPIT
NEW MATERIAL:3-Acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5-tri-me-thoxyphe netyl) amino]butoxy]phenyl]benzothiazoline of formula I. USE:It has hypotensive, thrombocyte coagulation-inhibiting and calcium antagonistic activities, and is useful as a drug effective to hypertension, thrombosis, stenocardia, arrhythmia, etc. It has especially excellent hypotensive activity and durable activity. It can be administered orally or parenterally. PREPARATION:The compound of formula I can be prepared according to the reaction formula, e.g. by reacting 3-acetyl-2-(2-hydroxy-5-methoxyphenyl) benzothiazoline with 1,4-dibromobutane in the presence of a base such as sodium hydroxide, and heating the reaction product in the presence of a base.
PURPOSE:To obtain a plaster sheet for skin by laminating a vinyl chloride resin film to a polyethylene terephthalate film, successively forming 1st and 2nd primer layers on the surface of the polyethylene terephthalate layer of the obtained composite film and forming a tacky adhesive layer containing an agent on the primer layers. CONSTITUTION:A 1st primer layer is formed on the surface of a polyethylene terephthalate layer of a composite film produced by laminating a soft vinyl chloride resin film to a polyethylene terephthalate film. A 2nd primer layer is formed on the 1st primer layer and a tacky adhesive layer composed of a styrene-diene-styrene block copolymer is laminated and bonded to the 2nd primer layer to obtain a sheet for applying to the skin. The 1st primer layer is composed of a composition produced by compounding a polyurethane having OH terminals with a saturated polyester resin, an ethylene-vinyl acetate copolymer, a chlorinated rubber and fine powder of anhydrous silica. The 2nd primer layer is formed by the gravure-coating of a mixture same as the 1st primer layer. The thickness of the polyethylene terephthalate film used in the substrate is <=10mum.
After core build-up and initial tooth preparation, a clinical crown lengthening procedure (CLP) will be performed. Restorative treatments will be initiated 12 weeks after CLPs.