anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sarcopenia has been associated with adverse health outcomes, including cognitive dysfunction. However, its specific interrelationship with neurocognitive disorders such as mild cognitive impairment (MCI), Alzheimer's disease (AD) or other types of dementia has not been thoroughly explored. This meta-analysis aims to summarize the existing evidence on this interrelationship. This systematic review was pre-registered on PROSPERO (CRD42022366309) and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Databases, including PubMed, Embase, CINAHL, Scopus, Web of Science, PEDro, SPORTDiscus and the Cochrane Central Register of Controlled Trials, and the data registry ClinicalTrials.gov were searched from inception to 8 June 2023. Observational studies (cross-sectional and cohort) and interventional studies reporting on the association and prevalence of sarcopenia in MCI, AD or other types of dementia in adults ≥50 years were included. For the meta-analysis, pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association of sarcopenia with the neurocognitive disorders using random-effects/fixed-effects models. Subgroup analyses were performed to identify potential sources of heterogeneity. A total of 77 studies consisting of 92 058 subjects were finally included in the qualitative analysis (71 cross-sectional, 4 cohort and 2 interventional studies). Studies were heterogeneous, using different diagnostic criteria to define both sarcopenia and cognitive status. The majority of studies (n = 38) included Asian community-dwelling older adults. Most studies investigated the association of sarcopenia with AD (33/77) and MCI (32/77). For studies focusing on other forms of dementia, two studies included Lewy body dementia and one study included Parkinson's dementia, whereas the remaining studies did not specify dementia aetiology (n = 21). Three cohort studies explored the association between sarcopenia and incident MCI, whereas only one cohort study explored the association between dementia and incident sarcopenia. Two interventional studies investigated whether an exercise programme could prevent the progression of sarcopenia in older adults with dementia or AD. The information for the meta-analysis was extracted from 26 studies. Sarcopenia was significantly associated with MCI (pooled OR = 1.58, 95% CI 1.42-1.76) (n = 14), AD (pooled OR = 2.97, 95% CI 2.15-4.08) (n = 3) and non-AD dementia (pooled OR = 1.68, 95% CI 1.09-2.58) (n = 9). The significance and magnitude of the associations differed in subgroup analyses by study design, population, definition of sarcopenia or used tool to measure cognitive status. This meta-analysis showed that sarcopenia is significantly associated with MCI, AD and other types of dementia. These findings suggest the importance of early screening and prevention of sarcopenia in older people with cognitive dysfunction, although further longitudinal research is needed to clarify the causal relationship.
A method for guided patient charting is provided. The method may include, by a patient charting apparatus, receiving a context based on patient history, visit reason, age, gender, and/or policy, and identifying recommended workflows based on the context, an access control list, and/or a rule set. The recommended workflows may then be visually distinguished from that of the non-recommended workflows. Recommendations at the field-level may also be provided. Administration of workflow settings is provided. Corresponding apparatuses and computer program products are also provided.
Inhibiting expression of a target gene by RNA interference, where the target region is selected from that which has another complementary or near complementary region(s) in the same target gene so that a natural hairpin structure of a dsRNA or multiples of the same or different hairpin dsRNA could have been formed. Inhibiting expression of a target gene in a cell comprises introducing a double stranded or other forms of RNA (dsRNA and other small interfering RNA precursors siRNAp) enabling siRNA, where the dsRNA and siRNAp comprise, in most cases, a double stranded structure or a single stranded hairpin structure with an identical or near identical sequence as compared to a region of the target gene. The region selected for inhibition, will be a region that should have another complementary or near complementary region(s) in the same target gene so that a natural hairpin structure of a dsRNA or multiples of the same or different hairpin dsRNA could have been formed, at least in theory, de novo from that particular targeted gene. For practical purposes, the best match sometimes can only be found for the first 4-12 nucleotides or so since the chance of a match is exponentially more difficult after that number. The match may not be restricted to start from the first 4-12 nucleotides but may start and end from and in any position. This concept is applied for the selection of the right sequences for dsRNA and siRNAp to enable target gene silencing. ACTIVITY : Respiratory-Gen.; Anti-HIV; Cytostatic; Viricide; Antibacterial; Antifungal; Antiparasitic. No biological data given. MECHANISM OF ACTION : Gene therapy; RNAi; RNA interference.
The invention relates to a traditional Chinese medicine powder for treating animal hoof hot. The medicine powder is prepared from the following traditional Chinese medicine in parts by weight: 7-13 parts of frankincense, 7-13 parts of calcined keel, 7-13 parts of lithargite, 9-15 parts of cutch, 0.1-0.5 part of musk, 1-5 parts of borneol and 3-9 parts of sodium borate. The optimum proportioning scheme is as follows: 10 parts of the frankincense, 10 parts of the calcined keel, 1- parts of the lithargite, 12 parts of the cutch, 0.3 part of the musk, 3 parts of the borneol and 6 parts of sodium borate. A preparation method of the powder comprises: crushing the raw materials weighted in parts by weight into fine powder. The powder is sprayed for 5-6 times per day, and one course of treatment comprises 5 days. According to the invention, the problems of less medicaments for treating the animal hoof hot and slow curative effect of the existing medicaments for treating the animal hoof hot and the like are solved; and the powder in the invention has the advantages of good efficacy,,low cost and the like, and is convenient to use.
### Mechanism of action

Terconazole, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. This enzyme functions to convert lanosterol to ergosterol. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell wall and may be responsible for the antifungal activity of terconazole. Mammalian cell demethylation is less sensitive to terconazole inhibition.

### Activity in vitro

Terconazole exhibits antifungal activity in vitro against Candida albicans and other Candida species. The MIC values of terconazole against most Lactobacillus spp. typically found in the human vagina were ≥ 128 mcg/mL; therefore these beneficial bacteria are not affected by drug treatment.
Weight-adjusted dose of 3-OHB Monoester (KetoneAID KE4, Virginia, US). Bolus of 300 mg/kg followed by a 2-hour continuous enteral infusion with a dosing of 100 mg/kg/hour (maximal total dose 50 grams). There is a 1-hour lag between the bolus and the continuous infusion.
Group A will receive sacubitril/valsartan + placebo for weeks 1-12. and then sacubitril/valsartan only for weeks 13-32. All subjects in Group A will also receive longitudinal pulmonary artery pressure monitoring using a previously placed implantable hemodynamic monitor (CardioMEMS device).
Chronic pain is a public health problem suffered by 20% of the world's population. Pharmacological approaches are insufficient, so a multi-therapeutic approach that also includes non-pharmacological therapies (psychological therapies, meditation, physical exercise, healthy habits, etc.) is proposed. The aim of this review was to review the existing scientific evidence on the effect of multicomponent programs with non-pharmacological therapies in people with chronic non-oncologic pain. To this end, a search for scientific articles was carried out in three databases (PubMed, Web of Science and PsycINFO) and 17 articles were selected, following the PRISMA recommendations. The patients who participated in these programs were mostly women, aged 18 to 80years, working or on sick leave due to pain, with secondary education or less and married. The most frequent pain was musculoskeletal, mainly low back pain. All the articles studied the effectiveness of two or more therapies, highlighting psychological therapies, physical exercise and education. Positive results were obtained in the reduction of different variables such as pain, pain catastrophizing, anxiety and depression, in addition to improving functionality and quality of life. It has also been shown that patients' prior expectations regarding the intervention influence its effectiveness. Although throughout the review there was great heterogeneity in the interventions, in the evaluation methods and in the results themselves, it can be concluded that multicomponent programs show positive results in the management of chronic pain, and should therefore be incorporated as a routine therapeutic treatment.
PROBLEM TO BE SOLVED: To obtain a prophylactic or inhibitive agent for virus disease of aquatic life capable of prophylactic or inhibition of a virus disease of aquatic life, specifically an iridovirus infections disease of cultured fish or shell fish in an effective safe manner by oral administration, which is easy for administration by including a eucalyptus extract. SOLUTION: This agent is composed of a eucalyptus extract. Eucalyptus globulus and Eucalyptus sitriodora are preferably used as the eucalyptus. The extraction of eucalyptus is preferably carried out by using ethanol at 20-90 deg.C. The obtained extract is preferably fractionated with an alcohol or fractionally purified by chromatography. The eucalyptus extract may be formulated during the manufacturing process of feed, or it may be formulated in a commercially available feed product. The formulation amount of the eucalyptus extract is preferably 0.1-10% based on the weight of feed in terms of the dry weight of the extract. The cultured fish and shell fish to which the diet feed is applied include especially high class cultured fishes such as red sea beam, yellowtail, prawn and eel.
Radiotherapy was administered using Intensity-Modulated Radiation Therapy (IMRT) technique, with a prescribed dose of 60 Gy in 30 fractions. Chemotherapy with paclitaxel at 135 mg/m2 and cisplatin at 70 mg/m2 was intravenously infused for two cycles during the 1st and 4th weeks. After the completion of radiotherapy, there was a rest period of 4 weeks, followed by continuation of the TP regimen for consolidation chemotherapy for 4 cycles.
Methods, systems and computer program products for data analytics. An information ecosystem comprises a plurality of participants and a plurality of data sets associated with the participants. An event initiates performance of a computation over different obfuscated data sets to determine an obfuscated computational result. An integrity value pertaining to constituent data of the different obfuscated data sets and, correspondingly, an integrity value pertaining to the computational result itself, is quantified by checking if the earlier offered data set or any constituents thereof are consistent with one or more aspects of later retrieved data. Certain variations of methods, systems and computer program products are used for verifying data accuracy in privacy-preserving computations that are performed in a health ecosystem where the data sets pertain to health information associated with the participants. When the integrity value is below a threshold, the data is deemed to include falsified or inaccurate data.
Children with Down syndrome will undergo an 8-week occupational therapy home program (OTHP). Evaluations will be conducted at the beginning and end of the intervention, and the results will be compared.
INTRODUCTION: Suicides are the second most common cause of non-natural death in Germany after accidents. Most common is death by hanging, followed by the use of firearms. More frequent "simple" suicides in which one suicide method is used are distinguished from rare "complex" suicides, in which several methods are applied, whereby the combination of gunshot and strangulation is frequently chosen. Such cases require a thorough criminalistic and forensic medical examination to check the plausibility of assumed sequences of events and to detect covered-up homicides.
MATERIAL AND METHODS: A retrospective analysis of 5,400 post-mortem examinations at the Institute of Legal Medicine Giessen (2009-2018) revealed three cases in which gunshot and hanging were used to commit a planned complex suicide.
RESULTS: Case 1: The body of a 66-year-old carcinoma patient was found hanging from a tree in a kneeling position with a bullet through the head. The post-mortem examination revealed a penetrating head shot, uninjured soft tissues of the neck, no injuries to the hyoid bone or larynx and no signs of congestion. After autopsy, the gunshot through the head was considered as cause of death. Case 2: An 82-year-old man was found dead with two bullet wounds in the chest, hanging in free suspension in a factory hall. The necropsy showed two chest entry wounds with injuries to the heart and lungs as well as a vital ligature mark and fractures of the hyoid bone and larynx without signs of congestion. The combination of hanging and the gunshot wounds was concluded as cause of death. Case 3: The body of an 81-year-old pain patient was found in his home next to a small-caliber rifle, with a noose around his neck, attached to a suspension torn from the wall. The autopsy revealed a tangential shot through the skull with superficial injury to the frontal brain and a vital cord mark on the neck with fractures of the hyoid bone and larynx without signs of strangulation. In this case, hanging was identified as cause of death.
CONCLUSION: Complex suicides are rare events, that require a thorough criminalistic and forensic medical examination Although being called complex suicides and one of the methods usually being suitable to cause death, the cause of death is not always a combined one.
PURPOSE: Sprinting often provokes hip pain in individuals with femoroacetabular impingement syndrome (FAIS). Asphericity of the femoral head-neck junction (cam morphology) characteristic of FAIS can increase the risk of anterior-superior acetabular cartilage damage. This study aimed to 1) compare hip contact forces (magnitude and direction) during sprinting between individuals with FAIS, asymptomatic cam morphology (CAM), and controls without cam morphology, and 2) identify the phases of sprinting with high levels of anteriorly directed hip contact forces.
METHODS: Forty-six recreationally active individuals with comparable levels of physical activity were divided into three groups (FAIS, 14; CAM, 15; control, 17) based on their history of hip/groin pain, results of clinical impingement tests, and presence of cam morphology (alpha angle >55°). Three-dimensional marker trajectories, ground reaction forces, and electromyograms from 12 lower-limb muscles were recorded during 10-m overground sprinting trials. A linearly scaled electromyogram-informed neuromusculoskeletal model was used to calculate hip contact force magnitude (resultant, anterior-posterior, inferior-superior, medio-lateral) and angle (sagittal and frontal planes). Between-group comparisons were made using two-sample t -tests via statistical parametric mapping ( P < 0.05).
RESULTS: No significant differences in magnitude or direction of hip contact forces were observed between FAIS and CAM or between FAIS and control groups during any phase of the sprint cycle. The highest anteriorly directed hip contact forces were observed during the initial swing phase of the sprint cycle.
CONCLUSIONS: Hip contact forces during sprinting do not differentiate recreationally active individuals with FAIS from asymptomatic individuals with and without cam morphology. Hip loading during early swing, where peak anterior loading occurs, may be a potential mechanism for cartilage damage during sprinting-related sports in individuals with FAIS and/or asymptomatic cam morphology.
Sleep is a physiological state that is essential for maintaining physical and mental health. Sleep disorders and sleep deprivation therefore have many adverse effects, including an increased risk of metabolic diseases and a decline in cognitive function that may be implicated in the long-term development of neurodegenerative diseases. There is increasing evidence that microglia, the resident immune cells of the central nervous system (CNS), are involved in regulating the sleep-wake cycle and the CNS response to sleep alteration and deprivation. In this chapter, we will discuss the involvement of microglia in various sleep disorders, including sleep-disordered breathing, insomnia, narcolepsy, myalgic encephalomyelitis/chronic fatigue syndrome, and idiopathic rapid-eye-movement sleep behavior disorder. We will also explore the impact of acute and chronic sleep deprivation on microglial functions. Moreover, we will look into the potential involvement of microglia in sleep disorders as a comorbidity to Alzheimer's disease and Parkinson's disease.
The invention relates to the preparation of a chemical medicine agent, benflumelol used for curing the malaria. The present invention has advantages that: 1. Compared to the existing preparation capsule agent, the disintegration time limited is greatly shortened with rapid onset; 2. The auxiliary water soluble material sufficiently disperse the main non-water soluble ingredient, which is favorable for absorption of the main ingredient and the oral administration bioavailability can be improved; 3. The dropping pills of the present invention can be taken with water, or taken under tongue. The ingredient can be directly absorbed by the hypoglossis mucous membrane capillary vessel to avoid first pass effect of stomach and rapidly reach peak value of the blood concentration with rapid effect. The curative effect is improved; 4. As dropping pill of the present invention is rapid in absorption, short in detention time in stomach so that the generation of drug resistance and other side effects are decreased; 5. Simple production process and short production cycle can reduce the cost; 6. The invention overcomes not only inconvenience in applying the vein administration but also defects of low biological utilization ratio of other oral administrative regular preparation.
A system comprising: a molecular, dispersely-distributed chemical compound, a solvent and solid carbon dioxide, is processed in a high pressure homogenizer. This causes gaseous carbon dioxide to dissolve in the solvent. A micro- or nano-suspension of the chemical compound results. The system also contains tenside and stabilizers. One or more solvents are included, in which the chemical compound is soluble. Resultant particles of the compound, are amorphous, partially-crystalline or crystalline. The mean particle size is preferably 100-15 mu m. The chemical compound is a medicament, cosmetic, food additive, dye or pigment. The homogenizer is of the high pressure, piston/aperture type, preferably operating at 500-1500 bar. The micro- or nano suspension obtained, is used either directly, or after separation of the particles. It may be processed to an intermediate- or final product.
The present invention relates to a cosmetic composition containing an extract of Sambucus williamsii var. coreana and Clematis mandshurica Rupr as an active ingredient. More specifically, the cosmetic composition contains the mixed extract of Sambucus williamsii var. coreana and Clematis mandshurica Rupr and thus has a significantly increased synergy effect of alleviating wrinkles. Therefore, the cosmetic composition can be used for a cosmetic, which has an effect of promoting collagen generation in the skin, an effect of inhibiting MMP-1 generation, and excellent activity of inhibiting elastase and can alleviate wrinkles. The extract contains Sambucus williamsii var. coreana and Clematis mandshurica Rupr at a weight ratio of 1:10-10:1. The mixed extract is submicron-capsulized or micro-capsulized, or is processed into a liposome.
PROBLEM TO BE SOLVED: To obtain the subject reagent readily penetrating skin and having compatibility with the skin of a test specimen by mixing a purified protein of the same kind as the protein produced by Mycobacterium tuberculosis and Mycobacterium bovis during propagation, and not produced by other acid-fast bacteria, with a nonionic surfactant in a specific proportion in a diluent. SOLUTION: The objective reagent is obtained by mixing 1-100 pts.wt. purified protein (preferably MPB64) of the same kind as the protein produced by Mycobacterium tuberculosis and Mycobacterium bovis, and not produced by almost other acid-fast bacteria in the whole acid-fast bacteria capable of infecting and attacking a human being, with a trace of nonionic surfactant in 100 pts.wt. diluent. The objective reagent preferably comprises the first reagent of one of the before reagent, and the second reagent obtained by mixing 1-75 pts.wt. purified protein of the same kind as the protein not produced by the Mycobacterium tuberculosis but produced by the Mycobacterium bovis during propagation, with a trace amount of nonionic surfactant in 100 pts.wt. diluent.
PURPOSE:To obtain a core or core-shell polymer containing an active component such as pharmaceuticals and agrochemicals in the core, exhibiting excellent dispersion stability and sustained releasability of the active component, having uniform particle diameter and useful in the field of pharmaceuticals, agrochemicals, etc. CONSTITUTION:This core or core-shell polymer containing an active component such as lipophilic pharmaceuticals and agrochemicals in the cores is produced, e.g. by involving the active component in the core. The particle diameters of the core polymer (Fig.1) and the core-shell polymer (Fig.2) are preferably 50-800nm and 100-1,000nm, respectively. The seed, core and shell constituting the polymer are successively produced by emulsion polymerization and each constituent element is composed of a synthetic resin such as PS, 1-8C alkyl (meth)acrylate polymer, etc. The active component such as pharmaceuticals and agrochemicals may be involved in the seed and the core and the amount is 0.01-20wt.% based on the total polymer. Preferably, the active component is involved in the core and its amount is 0.1-10wt.% preferably 1.0-8.0wt.%.