anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicinal compound for preventing and treating liver cancer and a preparation method of the traditional Chinese medicinal compound. The traditional Chinese medicinal compound is prepared from the following crude medicinal materials in parts by weight: 60-70 parts of radix pseudostellariae, 35-45 parts of semen myristicae, 45-55 parts of fructus evodiae, 15-25 parts of rhizoma coptidis, 35-45 parts of fructus psoraleae, 25-35 parts of medicinal cyathula root, and 50-70 parts of bark of Phellodendron amurense Rupr. and radix angelicae pubescentis (the ratio of the weight parts of Phellodendron amurense Rupr. to radix angelicae pubescentis is (4-6) to 1). The microvessel density in the tumor can be taken as a novel tumor biological feature, which can reflect the inevitable relationship between the formation strength of the tumor microvessel and the tumor invasion. The traditional Chinese medicinal compound provided by the invention can obviously inhibit the growth of the transplantation tumor of the liver cancer, and can be developed into the medicine for treating liver cancer; and the effect of the traditional Chinese medicinal compound is possibly relevant to the ratio of the weight parts of the bark of Phellodendron amurense Rupr. to radix angelicae pubescentis.
Beta blockers (BB) and calcium channel blockers (CCB) are highly effective to suppress angina attacks. Current observational study is designed to investigate the effectiveness of BB, CCB and its combination in angina patients. Angina patients from different tertiary care hospital cardiology OPDs were recruited from June 2022 to June 2023. Patient's history and suspected adverse drug effects (ADE) observed by manual chart review. Results showed baseline demographics and comorbidities were similar. Medication assessment revealed that most patients were on CCB (54.4%) and BB (36.36%) than combination (9.8%). Compared with BB, CCB and combination drugs taking patients represented stable heart rate and blood pressure (P<0.05). There were insignificant differences were observed in electrolytes and lipid profile in each groups. In addition, the Seattle questionnaire for angina (SQA) showed improved symptoms in 83 patients out of 110 (P<0.05). Further ADE were observed by using Naranjo scale that represented BB taking patients were found to have more ADRs than CCB and combination therapy. In conclusion, patients using BB, CCB or a combination of CCB+BB had improved angina symptoms and represented same efficacy however CCB exhibited lesser number of ADRs that shows CCB is more effective than BB in prolong use of angina control.
This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls. These compounds include nialamide, isocarboxazid, phenelzine, amoxapine, loxapine and mefloquine. Also compositions including one or more of such compounds for use in inhibiting glucuronidase and methods of using one or more of such compounds for selective inhibition of bacterial β-glucuronidase. These compounds may be used as a co-drug in combination with the anticancer drug CPT-11. Also a method for screening compounds to determine their usefulness in reducing diarrhea associated with irinotecan chemotherapy.
This research study will analyze results from a Penn Medicine Opioid Task Force initiative using a two-arm stepped-wedge cluster randomized trial design. The feedback intervention will be rolled out across all participating Penn Medicine surgical departments and divisions currently using Penn Medicine's post-operative text-messaging learning health system platform. Timing of intervention roll-out within each department and division will be randomly assigned to permit evaluation of the effect of the intervention.

With the stepped wedge design, not only will all attendings and associated prescribers ultimately receive the intervention, but by the end of the trial, each will be actively using the intervention, meaning its sustenance would occur automatically. A stepped-wedge design will be utilized, in which all clinicians begin in usual care and the order in which they adopt interventions is randomly assigned, because it has both practical and scientific advantages over traditional parallel-cluster randomized designs, in which randomization determines which clusters adopt the intervention at all. Importantly, the stepped-wedge design provides time to prepare surgical divisions for implementation of the intervention(s), enhances stakeholders' enthusiasm for participating by ensuring that each will receive the intervention(s), and typically increases statistical power. The primary analysis of study outcomes will be conducted at the patient-level. Secondary analyses will be conducted at the prescriber and attending surgeon level.
The subjects in this study were women of reproductive age. From September 2015 to December 2022, sixty women with known endometriosis \[stage 2 and 3\], were recruited. Their mean age was 38 years. They were nulliparous and had a mean BMI of 27 kg/m2. The ovarian endometrioma, present in all the participants, was diagnosed by ultrasonography and/or magnetic resonance imaging.

This was a prospective randomized follow up study with analysis of ovarian samples derived from GnRH agonists-treated and non-treated women before surgery. The randomization was performed by accessing a central internet-based randomization program. The random allocation sequence and the assignment of the participants to interventions were made by 2 of the authors \[A.K. and S.K\].

After enrollment, patients were divided into 2 groups . During laparoscopy, biopsy specimens of the ovarian endometrioma were collected. The staging of endometriosis was based on the rASRM classification system. In group B, surgery was performed during the proliferative phase of the menstrual cycle. All biopsy specimens were collected in accordance with the guidelines of the Declaration of Helsinki and with the approval of the ethical committee of the General University Hospital of Patras. Informed consent was obtained from all women.
Inhaled room air plus intravenous midazolam bolus (total 2mg). Midazolam-condition participants will receive intravenous infusions of 0.5mg midazolam in 5ml saline (start of 1st inhalation epoch), followed by 1.5mg midazolam in 5ml saline (start of 2nd inhalation epoch).
BIO-Precision is a post-market study investigating the utility of atrial fibrillation (AF) detection using BIOTRONIK's subcutaneous cardiac rhythm monitor, BIOMONITOR. The purpose of this study is to evaluate the diagnostic utility of BIOTRONIK's BIOMONITOR for the detection and confirmation of AF prior to an ablation procedure. Study population includes patients with paroxysmal AF being evaluated for an AF ablation. Holter monitoring for 48 hours will be performed after insertion of the BIOMONITOR but prior to AF ablation. This study will enroll up to 100 subjects, to obtain 60 usable Holter recordings, at 5 study sites within the United States (U.S.). Study subjects will be followed for three months after the completion of a 48 hr Holter monitor.
FIELD: organic chemistry and technology, biochemistry. SUBSTANCE: invention relates to the improved method of synthesis of aciclovir. Method involves an alkylation of N-formylguanine with 2-oxa-1,4-diacylhydroxybutane and hydrolysis of an intermediate compound in the presence of acid catalyst. Aciclovir - 9-(2-hydroxy)-ethoxymethylguanine is the known antiviral agent. Method provides synthesis of aciclovir without its nonfavorable by-side 7-isomer of the end product practically. EFFECT: improved method of synthesis. 7 cl, 2 dwg, 4 ex
The invention relates to the technical field of cosmetics, and particularly discloses a composition for relieving seborrheic alopecia, shampoo, essence and a preparation method thereof. A composition for relieving seborrheic alopecia comprises hydrolyzed corn starch, polyglutamic acid and its salts, sodium chloride, essence, acyl glycine, anti-alopecia agent, salix alba bark extract, galla chinensis extract, folium Platycladi extract, yeast fermentation product, herba Saussureae Involueratae extract, and fructus Sapindi Mukouossi extract. Shampoo comprises composition for relieving seborrheic alopecia, surfactant, etc. The essence comprises a composition for relieving seborrheic alopecia, propylene glycol and the like. A preparation method of essence for relieving seborrheic alopecia comprises mixing the above materials to obtain essence for relieving seborrheic alopecia. The application has the effects of controlling scalp grease secretion, supplementing scalp moisture and relieving seborrheic alopecia.
Systems and methods for radiation treatment planning based on a model of planning strategies knowledge including treatment states and treatment actions are disclosed. According to an aspect, a method includes receiving geometric characterization data of a target volume for radiation treatment of a patient. The method also includes receiving geometric characterization data of at least one organ at risk proximate the target volume. Further, the method includes constructing a model for applying a predetermined radiation dosage to the target volume based on the received data. The model includes treatment states and associated treatment actions selectable to implement at each state. The method includes presenting information about at least one treatment state, the treatment actions associated with the at least one treatment state, and the rewards associated with the treatment actions associated with the at least one treatment state. The method also includes reconstructing the model.
BACKGROUND: Orthopedic surgeons face challenges regarding perioperative bleeding during the operations of pelvic and acetabular fracture cases. Although the recently popular tranexamic acid (TXA) has proven to be a useful tool, this study primarily aimed to conduct a retrospective comparative analysis of the results of the prophylactic administration of tranexamic acid during open fixation of pelvis and acetabulum fractures, especially regarding operative time and the amount of blood transfused; and in addition, share the results related to other findings including the management of the erythrocyte suspension use and overall cost as secondary aims and thus providing a comprehensive point of view.
METHODS: The files of patients with pelvis or acetabulum fractures admitted to the Emergency Clinic of the Adana City Training and Research Hospital between January 1, 2020, and December 31, 2023, were analyzed retrospectively. The inclusion criteria were as follows: patients aged 18 years or older who had undergone open reduction for pelvis or acetabulum fractures.
RESULTS: There were 78 files identified for analysis. Among the fractures, 27 were located at the pelvis (34.61%) and 51 at the acetabulum (65.38%). The pelvic fracture cases' age and preoperative hemoglobulin levels were significantly lower (p = 0.019 and p = 0.006, respectively). When all cases were dichotomized into two groups, ones requiring ICU monitoring and the remaining, there were statistically significant differences in terms of the preoperative hemoglobin levels (p = 0.0446), intraoperative bleeding (p = 0.0134), units of erythrocyte suspension used (p = 0.0066), drain output (p = 0.0301), hospitalization duration (p = 0.0008), and the overall cost (p = 0.0002). The comparison regarding TXA use showed that the use of blood products was significantly higher in the pelvic fractures not treated with TXA (6.44 ± 4.42 units, p = 0.0029). The duration of surgery was shorter for pelvic fractures treated with TXA (98.33 ± 21.76 min, p = 0.047).
CONCLUSION: Among the variables, the amount of intraoperative bleeding emerged as the most correlated element, which strongly suggests that in managing open reduction internal fixation surgeries performed for pelvis and acetabulum fractures, intraoperative bleeding should be considered as the crucial factor. Therefore, the administration of TXA, by effectively reducing the amount of intraoperative bleeding, should be considered as an essential tool for orthopedic surgeons.
IUI can be used to treat infertility when tubes are normal, with no severe endometriosis and enough motile spermatozoa can be inseminated. In these cases IUI are usually performed (4 to 6 attempts) and IVF only in case of IUI failure. Indeed if the pregnancy rate per attempt is higher with IVF, IUI can be performed more frequently (6 times a year vs. 2 for IVF) so that the pregnancy rates after one year of treatment are close. When female age is over 37 years, some ART centers prefer to perform directly IVF, since chances of pregnancy decreases with time. However there is no argument in the literature in favor as well as in disfavor for such an attitude. Indeed the delivery rates after one year treatment with IUI or IVF are not known in this population. Therefore we propose a multicentric randomized controlled trial comparing IUI and IVF in women over 37 with unexplained infertility. Couples will be randomly allocated to IUI or IVF during one year. In case of absence of pregnancy after 4 IUI, couples will be treated by IVF. ART attempts will be performed according to usual procedures of each center. The follow-up will be ended either at the end of the first year of treatment if no pregnancy is obtained or at the time of delivery if a pregnancy is obtained. All data of attempts (demographics data, type and doses of treatment, adverse effects, outcome, number and health state of newborns....) will be recorded.
During hospitalization, routine postpartum education and discharge instructions will be provided, including the distribution of promotional brochures and guidance on performing puerperium recovery exercises. Patients will be instructed to join the control group's WeChat group. After discharge, researchers will upload instructional videos for the recovery exercises and urge patients to perform the postpartum recovery exercises twice daily, each session lasting 10-15 minutes. Patients are required to upload their exercise videos twice a week, and researchers will provide motion guidance based on the video content until the patient's postpartum follow-up examination.
Overdosage with atenolol has been reported with patients surviving acute doses as high as 5 g. One death was reported in a man who may have taken as much as 10 g acutely. 

The predominant symptoms reported following atenolol overdose are lethargy, disorder of respiratory drive, wheezing, sinus pause and bradycardia. Additionally, common effects associated with overdosage of any beta-adrenergic blocking agent and which might also be expected in atenolol overdose are congestive heart failure, hypotension, bronchospasm and/or hypoglycemia. 

Treatment of overdose should be directed to the removal of any unabsorbed drug by induced emesis, gastric lavage, or administration of activated charcoal. Atenolol can be removed from the general circulation by hemodialysis. Other treatment modalities should be employed at the physician's discretion and may include:
The invention discloses a traditional Chinese medicine composition for preventing and curing diarrhea of suckling pigs. The traditional Chinese medicine composition mainly comprises the raw materials including 16 parts by weight of windflower, 8 parts by weight of common andrographis herb, 8 parts by weight of radix sophorae flavescentis, 8 parts by weight of Scutellaria baicalensis, 8 parts by weight of isatis root, 10 parts by weight of folium isatidis, 6 parts by weight of Astragalus mongholicus, 4 parts by weight of Codonopsis pilosula, 6 parts by weight of golden cypress, 5 parts by weight of Poria cocos, 6 parts by weight of cortex fraxini, 6 parts by weight of myrobalan, 4 parts by weight of white paeony root, 4 parts by weight of akebiaquinata, 4 parts by weight of elecampane and 6 parts by weight of liquorice. The pure traditional Chinese medicine composition is adopted; all drugs are combined to use so that the composition has the functions of clearing heat, detoxicating, resisting bacteria, diminishing inflammation, tonifying middle and qi, invigorating the spleen, promoting the secretion of saliva or body fluid, tonifying qi, eliminating toxin, regulating qi, circulating milk, blood milk barrier passing, and the like. The composition is applied to feed sows and can be used for preventing and curing diarrhea of suckling pigs resulted from a plurality of reasons and reducing disease incidence of piglets. The traditional Chinese medicine disclosed by the invention is applied to sows so as to prevent and cure diarrhea of suckling pigs in a simple dosage form and a drug delivery approach. The composition has low stress without residual and is nontoxic and harmless. The composition accords with the requirements of scale cultivation and production.
The invention belongs to the field of skin care products, and particularly relates to a micro-nano bubble oxygen-enriched water aerosol and a preparation method thereof. The micro-nano bubble oxygen-enriched water aerosol consists of micromolecular polypeptide, ozone, oxygen and purified water. Adding deionized water into a reaction container, fully mixing medical oxygen with the deionized water by a micro-nano bubble generating device, and preparing micro-nano bubble oxygen-enriched water. And adding the prepared ozone water and the micromolecular polypeptide into the oxygen-enriched water according to the proportion, and fully stirring and uniformly mixing the ozone water and the micromolecular polypeptide. And then filling the oxygen-enriched water aerosol into an aluminum pot bottle, and filling medical oxygen after passing through a pressure valve to obtain the micro-nano bubble oxygen-enriched water aerosol. The micro-nano bubble oxygen-enriched water aerosol has no irritation, can inhibit the breeding of propionibacterium acnes, and has the functions of inhibiting bacteria, removing acnes, repairing, promoting the growth of cells and the like.
The invention relates to the technical field of immune cell production, in particular to a method for separating cells by density gradient centrifugation and a preparation method of CAR-T cells. The method for separating cells by density gradient centrifugation provided by the invention can realize the separation of living cells and dead cells by optimizing the solution used in centrifugation and the washing condition. The beneficial effects of this scheme include at least: (1) the method can increase the proportion of surviving T lymphocytes. (2) For the subjects treated by multiple rounds of chemotherapy, the cell viability can be improved, the virus usage amount required by transfection can be reduced, the proportion of enriched memory T lymphocytes can be improved, and the proportion of inhibitory cells can be reduced. (3) The method can remove cell subpopulations in early apoptosis, improve proliferation capacity, and enrich cell groups with high proliferation capacity. (4) The method is simple and easy to operate, is not only suitable for manual separation, but also can adopt automatic equipment to separate cells and carry out gene modification.
In the general population, individuals with elevated inflammatory markers (e.g. C-reactive protein, CRP) have increased cardiovascular disease. Patients with RA have chronic elevations in CRP and other inflammatory markers that are usually higher than the levels associated with increased cardiovascular risk in the general population. Indeed, RA patients have accelerated disease of their blood vessels, and increased cardiovascular death not explained by traditional cardiac risk factors but associated with chronic inflammation. However, the mechanisms by which inflammation leads to cardiovascular disease are not well characterized in RA. Moreover, current treatment strategies of RA largely target joint symptoms rather than inflammation, potentially leaving patients at increased risk for cardiovascular disease. Studies of markers that increase the risk of heart disease in the full spectrum of RA are missing. We hypothesize that inflammatory markers will be more strongly associated with abnormalities in blood vessels in RA patients than any clinical measure of disease activity. This hypothesis will be tested with a cross-sectional study of patients in the UCSF RA cohort. Aim 1 will characterize abnormal blood vessel changes across the spectrum of RA disease activity, specifically measuring ultrasound of the upper arm artery, markers of oxidative stress, and abnormalities in cholesterol proteins. Aim 2 will identify factors associated with these changes across the spectrum of RA disease activity, specifically focusing on the association between inflammatory markers, cholesterol, and blood vessel abnormalities.
PURPOSE: 6,7-Oxygenated steroids and uses related thereto are provided which are useful for treating asthma and an allergic disease effectively and safely. CONSTITUTION: Steroid compounds having various oxygen substituents on the steroid nucleus are described. A specific functional group that presents on many of the steroid compounds is an oxygen substituent at both of positions 6 and 7. Thus, certain steroids have an oxygen substituent at C6 and C7, and some have specific stereo chemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having the 6α and 7β oxygen substitution. Steroids having a 3,4-epoxy functional group are also described. In addition, steroids having C17 pyran and δ-lactone functional groups, with an oxygen substituent at C6 and C7, or at C15, of the steroid nucleus, are described.
The present invention discloses Method for preparing a precursor of contrast ligand. Firstly, take 2-Thiopheneethylamine and N-Carbethoxyphthalimide in the bonding reaction to obtain a first product. The first product is coupled to sulfuric acid to obtain a second product. And, take the second product and thionyl chloride in the substitution reaction to obtain a third product. And, take the third product and ammonia in the substitution reaction to obtain a fourth product. Finally, take the fourth product and methylamine in the bonding reaction to obtain a final product. The preparation method improves the problem of heavy metal residues and severe reaction conditions.
Emphysema is one of the major components of chronic obstructive pulmonary disease (COPD), which is characterised by the destruction and enlargement of air spaces, leading to airflow limitation and dyspnoea, finally progressing to oxygen dependency. The alveolar wall destruction is due to chronic inflammation, oxidative stress, apoptosis, and proteinase/anti-proteinase imbalance. So far, there has been no effective therapy for patients with COPD. We evaluated the therapeutic efficacy of tannic acid (TA), a naturally occurring plant-derived polyphenol in the murine emphysema model. In C57BL/6 J mice, we established emphysema by intratracheal instillation of elastase (EL). Then, mice were treated with TA and evaluated 1 and 21 days post-EL instillation. After 24 h, TA treatment significantly reduced EL-induced histopathological alterations, infiltrating leukocytes, and gene expression of markers of inflammation and apoptosis. Similarly, after 21 days, TA treatment suppressed the mean linear intercept, gene expression of proteinases, and increased elastic fiber contents in the lungs when compared to the EL-alone group. Furthermore, EL induced the activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa light chain enhancer of activated B cells (NF-kB) p65 pathways in the lungs was suppressed by TA treatment. In summary, TA has the potential to mitigate EL-induced inflammation, apoptosis, proteinase/anti-proteinase imbalance, and subsequent emphysema in mice.