anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a pharmaceutical composition for treatment of oral ulcers. The pharmaceutical composition is characterized in that it comprises the following components by weight: 5 parts of chitosan oligosaccharide, 1 part of a Salvia miltiorrhiza extract, and 0.15 part of menthol. The pharmaceutical composition of the invention is applied in wound surface repairing tests, and results show that wound surfaces generally heal and no obvious scar is left. Cell proliferation tests prove that the pharmaceutical composition has a good proliferation effect on cells, and the oral ulcer healing situation is obviously better than that of a control group. The inventor conducts acute toxicity tests on the pharmaceutical composition, and according to the grading standards of acute toxicity, the tested drug can be regarded as non-toxic. Therefore, the pharmaceutical composition of the invention can be used for treatment of oral ulcers, and have great clinical application value.
Wake Forest Baptist Health (WFBH) discharges over 1,000 patients annually after a critical illness such as septic shock and/or acute respiratory failure. This number is expected to be even higher due to the ongoing coronavirus pandemic. To try to bridge this gap, the Wake Forest Intensive Care Unit (ICU) Recovery Clinic was created in 2014. WFBH ICU Recovery Clinic (1 of \~15 nationwide) uses a multidisciplinary approach to transition care for ICU survivors back to Primary Care Physicians (PCPs). However, currently only about 5% of patients leaving the ICU who had respiratory failure and/or septic shock and may benefit from follow-up. In addition, patients seen in WFBH Recovery Clinic typically are only seen one time and then return to the care of their PCPs.

Poor physical function following critical illness is associated with hospital readmissions and mortality. However, barriers to post-ICU follow-up are common and include financial concerns as well as transportation barriers. Additionally, the Wake Forest ICU Recovery Clinic only sees patients once in the post-critical illness period, despite the fact that post-ICU morbidity remains high for at least six months following discharge. Finally, data demonstrates availability of internet services on a daily basis to the vast majority of the population (79% total of NC Congressional Districts 5, 6, and 13 in 2013; 68% in a random sample of 28 medical ICU patients). Taken together, this prompts the study team to propose this Wake Forest Post-ICU Telehealth (WFIT) program of a nurse practitioner who has access to daily activity data as well as telehealth capabilities in order to improve the post-critical illness care of these patients. The study team expects that this program will reduce costs to patients. Through this intervention the study team hopes to improve quality of life, patient satisfaction, reduce readmissions and ER visits, and reduce mortality. The study team will perform a formal randomized controlled trial with a cost-effectiveness analysis to demonstrate its value.
Vitamin E (alpha-tocopherol) is essential for humans but determining human dietary requirements has proved difficult. The recommended dietary allowance (RDA) for vitamin E is not met by 96% of American women, without apparent harm. Because vitamin E is an antioxidant, optimum consumption of vitamin E may improve the health of obese women who experience high levels of inflammation and oxidative stress. We hypothesize that vitamin E functions as an antioxidant is related to its tissue stores, and that delivery to tissue stores can be calculated from plasma vitamin E turnover kinetics from slow release pools. We propose turnover kinetics as a new means to estimate vitamin E recommended dietary allowance. We will study vitamin E pharmacokinetics using dual stable-isotope labeled (deuterium) alpha-tocopherols administered orally and intravenously to healthy nonobese, overweight and overweight non-insulin requiring diabetic women. Blood samples will be collected at intervals and vitamin E measured by mass spectrometry. Because ascorbic acid (vitamin C) concentrations may alter alpha-tocopherol pharmacokinetics, subjects will be studied first at low and then high steady state plasma vitamin C concentrations. Before this main study, two preliminary trials will be performed. In preliminary trial 1, fat content for optimal absorption will be assessed because fat-content of a meal may alter vitamin E absorption. The fat content in preliminary trial 1 will be 0 - 40% of calories in the breakfast meal during which vitamin E will be administered. In preliminary trial 2, optimal fat content from preliminary trial 1 will be used, and the vitamin E dose will be varied. Vitamin E dose amount could non-specifically alter vitamin E kinetics. We will therefore determine the largest dose (2-30 mg) that does not non-specifically increase vitamin E turnover, with fat held constant. Additionally, we will measure vitamin E pharmacokinetics as a function of lipid peroxidation biomarkers to provide direct data that can be used to predict vitamin E requirements for women, and to set new recommendations for vitamin E intakes. We will explore new alpha-tocopherol functions, specifically whether gene transcription in human subjects is regulated by vitamin E status in relation to vitamin C status. Because vitamin E turnover may be affected by vitamin C concentrations, we will use a vitamin C depletion-repletion study design to investigate the relationship between vitamin C status and vitamin E turnover.
This invention provides improved ophthalmic solutions useful for storing and/or delivering expression vectors. More specifically, this invention provides a stable aqueous ophthalmic composition comprising an expression vector and a vector stabilizing agent such as serum albumin, sucrose, or lactose. The stabilizing agent is in an amount that maintains the potency (i.e., expression efficiency) of the vector. This invention further provides method of ameliorating ocular diseases or conditions in a mammal using the same opthalmic composition, wherein the vector expresses a protein useful in the treatment of the ocular diseases or conditions. The ophtalmic composition can be administrated topically or systematically. Fig. 1 compares the expression efficiencies of a dnG1 vector in an ophthalmic solution of this invention (A), Genteal Lubricant Eye Drops (B), Three Tears (C), Refresh Tears (D), or Visine Tears (E) using viral titers.
Recognition molecule (I), directed against the gene for vascular endothelial growth factor (VEGF) is new. It interacts specifically with the mRNA of VEGF in the target sequence region 600-990 of M 32977. An independent claim is also included for pharmaceutical compositions, kits and/or arrays that contain (I). ACTIVITY : Cytostatic. MECHANISM OF ACTION : Inhibiting expression of vascular endothelial growth factor (VEGF). Treatment with (I) (a) increases sensitivity of tumor cells to cytostatic agents or radiation and (b) inhibits vitality and proliferation potential of cells, leading to cell-cycle arrest. The antisense oligonucleotide tggtgtggtggcggcagcgt complementary to region 732-742 of the mRNA for VEGF, was used to transfect the human bladder cancer cell line EJ28. This treatment reduced the cellular content of VEGF (protein) by more than 60% relative to a nonsense oligonucleotide and also reduced cell viability, causing death of almost all the cells.
An ultrasonic electronic rhinitis therapeutic apparatus with far-infrared atomized coconut essential oil is disclosed. The apparatus includes a nasal plug part and a nasal alar part. The nasal plug part includes an insertion column disposed in a nostril. The insertion column is internally provided with a coconut powder, and a far-infrared generating tube is arranged in the coconut powder. An ultrasonic generator is arranged in the nasal alar part, and the nasal alar part is fitted on the lateral side of the nasal alar. In the disclosure, the oil and acid substance in the coconut powder are atomized by far-infrared light and are atomized under the aid of pulse ultrasonic wave in the nasal cavity to be inhaled into the internal tissues of the nasal cavity, sinus and the like.
BACKGROUND: Given the established link between obesity and hyperuricemia (HUA), the research want to investigate the relationship between different obesity indices and HUA, and further analyze which obesity index can better predict HUA.
METHODS: The data were obtained from a longitudinal study involving middle-aged and elderly populations in Dalian, China. The research encompassed individuals who exhibited typical uric acid levels initially and tracked their progress over a three-year period. 8 obesity indices were evaluated retrospectively. Subgroup analyses were conducted to identify susceptible populations. Restricted cubic splines (RCS) were utilized to model the dose-response relationships between obesity indices and HUA. Receiver operating characteristic (ROC) curves were applied to visualize and compare the predictive value of both traditional and new obesity indices for HUA.
RESULTS: Among 4,112 individuals with normal baseline uric acid levels, 950 developed HUA. Significant associations with HUA were observed for body mass index (BMI), waist circumference (WC), body roundness index (BRI), cardiometabolic index (CMI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), lipid accumulation product (LAP), and abdominal volume index (AVI). Subgroup analysis indicated that all obesity indices proved more effective in assessing the onset of HUA in women without Metabolic Syndrome (MetS). Further analysis using RCS revealed non-linear dose-response relationships between LAP, CMI, VAI, and HUA in males, with similar non-linear relationships observed for all indices in females. The results from the ROC curves indicate that LAP may serve as a better predictor of HUA in males, and CVAI may serve as a better predictor in females.
CONCLUSION: HUA is closely associated with obesity indices. Among females, CVAI emerges as the preferred predictive index for HUA. In males, LAP emerges as the preferred predictive index for HUA.
Postoperative nausea and vomiting (PONV) are one of the most frequent complications after surgery, and are associated with patients' dissatisfaction after anesthesia and surgery. Orthognathic surgery is widely performed for the correction of dentofacial deformities. PONV is common after orthognathic surgery. Despite of improved anti-emetic prophylaxis, patients undergoing orthognathic surgery are reported to have a high incidence of PONV, especially those after bimaxillary surgery.

It is known that activation of central cholinergic system plays an important role in the development of PONV. Muscarinic antagonists such as scopolamine can block muscarinic receptors in the cerebral cortex and produce anti-emetic effects. Penehyclidine is a new muscarinic antagonists which selectively block M1 and M3 receptors. It has fewer adverse effects compared with other anticholinergics. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduce risk of PONV in patients undergoing bimaxillary surgery.
Disclosed are adipose matrices comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue. Disclosed are compositions comprising an adipose matrix comprising devitalized, or vitalized, and partially delipidized adipose tissue and MSCs. Disclosed are methods of making any of the disclosed adipose matrices or compositions. Disclosed are methods of treating a subject having a metabolic liver disease, metabolic disease, ischemic wound, or inflammatory disease comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing cholesterol in a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein. Disclosed are methods of decreasing lipids in the liver of a subject comprising administering to the subject a therapeutically effective amount of a composition disclosed herein.
Subjects are assigned to 12 cognitive training in-person sessions of the MTT245 program by a validated trainer. Cognitive evaluations are made initially week 1 and at the end of the intervention at week 12.
AIM: Atherosclerosis remains the pathological basis of myocardial infarction and ischemic stroke. Early and accurate identification of plauqes is crucial to improve clinical outcomes of atherosclerosis patients. Our study aims to evaluate the potential value of fibroblast activation protein inhibitor (FAPI)-04 PET/CT in identifying plaques via a preclinical rabbit model of atherosclerosis.
METHODS: New Zealand white rabbits were fed high-fat diet (HFD), and randomly divided into the model group injured by the balloon, and the sham group only with incisions. Ultrasound was performed to detect plaques, and FAPI-avid was determined through Al18F-NOTA-FAPI-04 PET/CT. Mean standardized uptake values (SUVmean) in lesions were compared, and biodistribution of Al18F-NOTA-FAPI-04 and target-to-background ratios (TBRs) were calculated. Histological staining was performed to display arterial plaques, and autoradiography (ARG) was employed to measure the in vitro intensity of Al18F-NOTA-FAPI-04. At last, the correlation among FAP levels, plaque area, SUVmean values and fibrous cap thickness was assessed.
RESULTS: The rabbit carotid and abdominal atherosclerosis model was established. Al18F-NOTA-FAPI-04 showed a higher uptake in carotid plaques (SUVmean 1.32 ± 0.11) and abdominal plaques (SUVmean 0.73 ± 0.13) compared to corresponding controls (SUVmean 1.07 ± 0.06; 0.46 ± 0.03) (P < 0.05). Biodistribution analysis of Al18F-NOTA-FAPI-04 revealed that the bigger plaques were delineated with higher TBRs. Pathological staining showed the formation of arterial plaques, and ARG staining exhibited a higher intensity of Al18F-NOTA-FAPI-04 in the bigger plaques. Lastly, plaque area was found to be positively correlated to FAP expression and SUVmean, while FAP expression was negatively correlated to fibrous cap thickness of plaques.
CONCLUSIONS: We successfully achieve molecular imaging of fibroblast activation in atherosclerotic lesions of rabbits, suggesting Al18F-NOTA-FAPI-04 PET/CT may be a potentially valuable tool to identify plaques.
Acupressure and shower are methods that can help reduce pain severity. This study thus aims to determine the effects of acupressure and shower on labour pain and postpartum comfort. This study was a randomized controlled trial (RCT). This study was the control group consisted of 40 pregnant women, while the experimental groups (acupressure and shower) consisted of 80 pregnant women in total. The experimental groups received routine labour care and either acupressure or showers upon reaching three cervical dilations (4-5, 6-7 and 8-10 cm). The control group only received routine labour care. A maternal information form (MIF), the Visual Analog Scale for Pain (VASP) and the Postpartum Comfort Questionnaire (PPCQ) were used to collect data. CONSORT checklist was used to report the current study.
Patients pathologic diagnosed of advanced non-small cell lung cancer, according to NCCN non-small cell lung cancer guide line(2014 V2),the patient should receive standard platinum based chemotherapy, are randomized divided into two groups, aprepitant group and placebo group. In aprepitant group, patients would receive aprepitant 125 mg at day1, then 80 mg at day2 and day3. In placebo group, patients would receive placebo from day1 to day3. In both group, dexamethasone and 5-HT inhibitor palonosetron were give at the same dose. During the treatment, any grade of nausea and vomiting should be recorded in order to evaluate the complete response rate of CINV, other side-effects should be recorded. In aprepitant group, plasma should be taken for the analyze of plasma concentration, gene polymorphism of CYP3A4 and NK-1 should be analyzed for all the patients who received aprepitant if possible.
FIELD: medicine. SUBSTANCE: the body is heated by placing it, except a head, into liquid heat carrier under condition of its obligatory convection by using anesthetic preparations, antishock therapy and artificial pulmonary ventilation and suppressing the total blood proteolytic activity. The heating is conducted at heat carriers' temperature being 44-48 C to reach body temperature of 42.0-44.5 C. Suppression of total blood proteolytic activity is performed by conducting continuous infusion of hexamethylenetetramine solution. Body heating is performed at the rate being not less than 1C/5.5 min. Infusion of hexamethylenetetramine solution is carried out at 2-6 mg/kg/min amount and, additionally, pyridoxine infusion is conducted at not less than 0.2 mg/kg/min. High-frequency artificial pulmonary ventilation is used by providing saturation at 95-100% level. EFFECT: increased efficiency due to total controlled hyperthermia. 3 cl, 1 ex
The present invention discloses a water dispersive bone morphogenetic protein injection preparation with nano level and a preparing method thereof. Phospholipid substances with good biocompatibility and cell compatibility serve as dispersing agents. Protein and polysaccharide serve as drug coating materials. Through controlling the proportion of the protein to the polysaccharide and the proportion of bone morphogenetic protein (BMP) to a mixture of the protein and the polysaccharide, the present invention adopts hetero-coagulation technology, and thus, water dispersive bone morphogenetic protein injection preparation with the particle diameter of 40 to 2000 nm is prepared. The coating materials used by the preparing method have the advantages of no poison, biodegradability and good biocompatibility. The water dispersive bone morphogenetic protein injection preparation can be used as an independent preparation to be directly applied, and can be combined with other biologic materials, and thus, materials which have good compatibility with cells and various tissues are further prepared. The present invention has the advantages of simple manufacturing technology and strong repetitiveness, and is suitable for various injection preparations of the protein class materials of water insolubility and water solubility.
Patients with iv self-administration of morphine, associated with paracetamol and ibuprofen. Each group will contain 60 patients.
Internet-CL is based on strategies for behavioral change and guidelines on health promoting lifestyle modifications following ACS. The Internet-CL is therapist-guided and lasts for 8 weeks.
INTRODUCTION: Surgical site infection after saphenous vein harvest is common, with reported leg wound infection rates ranging from 2 to 24%. There have been few investigations into sex-related differences in complication rates. Moreover, varied effects of smoking have been reported. The aim of this study was to investigate risk factors such as gender and smoking, associated with surgical site infection after vein graft harvesting in coronary artery bypass grafting surgery.
METHODS: We included 2,188 consecutive patients who underwent coronary artery bypass grafting surgery with at least one vein graft at our centre from 2009 to 2018. All patients were followed up postoperatively. Risk factors for leg wound infection requiring antibiotic treatment and surgical revision were analysed using logistic regression analysis.
RESULTS: In total, 374 patients (17.1%) received antibiotic treatment and 154 (7.0%) underwent surgical revision for leg wound infection at the harvest site. Female sex, high body mass index, diabetes mellitus, longer operation time, peripheral vascular disease and direct oral anticoagulants were independently associated with any leg wound infection at the harvest site. Among surgically revised patients, female sex and insulin or oral treatment for diabetes mellitus as well as longer operation time were independent risk factors. Smoking was not associated with leg wound infection.
CONCLUSION: Female sex is associated with increased risk of leg wound infection. The underlying mechanism is unknown. In the current population, previous or current smoking was not associated with an increased risk of leg wound infection.
A coating for a medical device, the device generally being of the type which is to be used internally in a subject, includes a transglutaminase (TGase) inhibitor. The Tgase inhibitor effectively prevents the activity of any Tgase involved in clot formation or clot stability. Preferably, the transglutaminase inhibitor is a factor XIIIa inhibitor. The coating may be prepared by suitable processes such as esterification. The coating may be immobilized on a suitable medical device in a number of ways and is preferably included in a TGase inhibitor containing polymer. The coating may also include a suitable antimicrobial agent.
Because of the inconvenience of nasopharyngeal (NP) testing for SARS-CoV-2 detection, we are interested in identifying different strategies for detecting infection. A technique that is less intrusive would put individuals undergoing testing at lower risk for complications, would likely increase compliance with subsequent tests, and would decrease risk to the providers who are conducting the test. For asymptomatic screening, some institutions are using midturbinate swabs instead of NP swabs, for increased compliance due to decreased discomfort. The NIH has switched to midturbinate collection in asymptomatic collections only. A test that would require only expectorating saliva and/or collection of a midturbinate swab would address the issues of NP collection discomfort. Saliva is the most preferred by patients or asymptomatic staff due to no collection in the nasal cavity at all. Although the CDC lists midturbinate swab as an acceptable specimen type, there are minimal data about the sensitivity of this collection for SARS-CoV-2, and decisions to use midturbinate swabs are based in part on experience with other respiratory viruses. Also, if saliva were found to be equivalent to NP for patient testing, there will be a benefit to future patients in providing this option for testing. Therefore, we propose to validate these sample types for SARS-CoV-2 detection. The RT-PCR results based on a saliva sample alone or a saliva sample coupled with a midturbinate swab, will be correlated with the results using surveillance or diagnostic swab samples to validate their use for SARS-CoV-2 detection.
1. Technical Result Improvement of technological process.         2. Essence The compounds of the formula (1)   (wherein R has the value indicated in the description), method for their preparation comprising activating the 11-hydroxyl of a compound of the formula (II) with an agent capable of selectively activating the hydroxyl in position 11, then reacting the resulting product with a base to obtain the compound of the formula (III) - reacting the latter carbonyldiimidazole, then with hydrazine NH2 NH2 (the compounds of formula I and II are provided in the description).         3. Field of Application Chemistry.
Fibrosis is commonly associated with chronic rheumatic diseases, and causes substantial morbidity and mortality. Treatment of fibrosis is extremely challenging but is badly needed, as approved antifibrotic therapies fibrosis do not halt its progression, which will be discussed with a focus on pulmonary fibrosis. Findings from recent studies indicate several therapeutic targets for treating fibrosis. Interleukin-11 is emerging as a fibrogenic cytokine whose activity can be blocked with neutralizing monoclonal antibodies. Fibroblast activation protein (FAP) is highly expressed by activated fibroblasts in inflammatory and fibrotic tissues. Targeting FAP with different modalities has been extensively explored as adjunct treatment for cancer, which can also apply to treating fibrosis in rheumatic diseases.