anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Teachers spend a significant amount of time in classrooms, which can be noisy environments. The aim of this scoping review was to determine what is known from the literature about the effect of classroom acoustic conditions on teachers' health and well-being.
METHOD: This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) protocol. Four bibliographic databases were searched: ERIC, PubMed, Scopus, and Web of Science.
RESULTS: Thirty-three articles were deemed relevant for the review. The most studied health aspect was teachers' vocal health. The majority of results showed higher noise levels or a higher number of students have a negative effect on teachers' health and well-being (61% and 60%, respectively), while 39% showed a negative effect of longer reverberation times. Most other results showed no effect.
CONCLUSIONS: These results show that poor classroom acoustic conditions can have a negative effect on teachers' health and well-being. Therefore, creating classrooms with good acoustic conditions and controlling noise is vital. Limitations are discussed, and future research to better understand the relationship between classroom acoustic conditions and teachers' health and well-being is proposed. This future research will help in understanding the acoustic conditions that are needed to optimize teachers' health and well-being in the classroom.
A system to manage records in a healthcare practice includes a server and a memory that stores patient data records and inventory equipment records. A check-in client computing device and first and second HCP client computing devices run apps that program respective devices to check-in patients for appointments, retrieve, and store patient healthcare data at the server. Display screens show approved appointments and the apps sort appointments as selected. The patient check-in app verifies that patients meet check-in requirements and locks the appointments of patients who do not. Apps retrieve patient data for the approved appointments and sort them. The server stores examination, treatment, and prescription data. Equipment inventory delivery data and returns data are stored. The server is programmed to communicate with all apps in their form and format of data and to translate all disparate data types into that form and format.
Axial spondyloarthritis, also referred to as ankylosing spondylitis, is a chronic inflammatory condition that predominantly affects the axial spine but may also present with peripheral arthritis. It falls within the umbrella of disorders known as spondyloarthropathies. In addition to axial spondyloarthritis, this group includes psoriatic arthritis, enteropathic arthritis, reactive arthritis, and undifferentiated spondyloarthropathy, with axial spondyloarthritis being one of the most common. The overall mechanisms underlying the development of axial spondyloarthritis are complex and multifactorial. There is a significant and well-recognized association between axial spondyloarthritis and the HLA-B27 gene, but there have also been non-HLA genes identified in the disease process, as well as certain inflammatory cytokines that play a role in the inflammatory process, such as tumor necrosis factor (TNF). More recently, there has been research and new evidence linking changes in the gut microbiota to the disease process of axial spondyloarthritis. Research into the role of the gut microbiota and gut dysbiosis is a large, ever-growing field. It has been associated with a multitude of conditions, including axial spondyloarthritis. This mini-review highlights the symbiotic relationship of the gut microbiota with the pathogenesis, therapeutic agents and future treatments of axial spondyloarthritis.
PURPOSE:To obtain a transfusion pharmaceutical, containing an amino acid and an electrolyte and excellent in stability and safety in sterilization and preservation. CONSTITUTION:The objection transfusion pharmaceutical is obtained by including an amino acid and further calcium and phosphorus as electrolytes and regulating the pH to 5-8 with an organic acid (e.g. citric acid). A polyhydric alcohol or a phosphoric acid ester of saccharides (e.g. glycerophosphoric acid) or salt thereof (e.g. sodium salt) as a supply source of phosphorus is blended and the amino acid concentration is 1-15% (wt./vol.). The resultant transfusion pharmaceutical does not produce precipitates, coloring, etc., even in thermal sterilization and deteriorate other transfusion pharmaceuticals when mixed therewith. Since operation to mix the amino acid with the electrolytes is not required, operation is simplified to prevent the pharmaceutical from being contaminated with microorganisms in mixing.
PURPOSE: To obtain a stable oil-in-water emulsion by containing an emulsifier, an oil phase and an aq. phase at specified proportions in an oil-in-water emulsion which contains metal oxide particles having a specified particle size. CONSTITUTION: In an oil-in-water emulsion contg. 0.5-30 wt.% of metal oxide (such as titanium dioxide) having an average primary particle size of <0.2 μm, at least one emulsifier (such as an aliphatic alcohol) in an amount of <10 wt.%, an oil phase (such as paraffin oil) in an amount of 5-30 wt.% and at least 60 wt.% of an aq. phase are contained, wherein % is based on the total weight of the emulsion. As a result, a stable oil-in-water emulsion can be obtained.
Arm E healthy volunteers will receive CYB003 in 3 of 3 medicine sessions, approximately one week apart from each other, to assess bioavailability and food effect. The CYB003 dose received will depend on the safety review committee selection/time of enrollment. All healthy volunteers will receive psychological support throughout the study.
<P>PROBLEM TO BE SOLVED: To provide a gelling agent for a gelled nutritive food simply preparing the gelled nutritive food by anyone without requiring special operation such as heating when mixed with the liquid nutritive food and imparting moderate viscosity to the liquid nutritive food without sticking to the interior of a feeding tube.  <P>SOLUTION: The gelling agent for the liquid nutritive food is composed of carrageenan and a mixture of locust bean gum with an extract from a tuberous root of devil's tongue and used in the form of a solution state. The carrageenan and the mixture is mixed in (5:1) to (15:1) mixing ratio. The carrageenan is contained at ≥1.0 wt./vol. concentration and the mixture is contained at ≥0.1% wt./vol. concentration, respectively in the solution.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This study investigated how the online health information behaviors of U.S. adults with illnesses unrelated to COVID-19 virus infection affected their coping with health problems and concerns during the COVID-19 pandemic. Guided by the cybercoping model (Kim & Lee, 2014), the study examined associations between these patients' online information behaviors (information seeking and information forwarding) and coping outcomes (health problems and affective states). The study further explored the mediating roles of health coping processes (problem-and emotion-focused) in the associations between these information behaviors and coping outcomes. Survey data from 687 participants were analyzed using structural equation modeling. The results highlighted the significance of information forwarding in enhancing both coping processes and outcomes, while information seeking enhanced problem-focused coping and health-problem coping outcomes alone. These associations were more pronounced among U.S. adults without chronic conditions than among those with chronic illnesses. These findings' implications, the study's limitations, and suggestions for future research were also addressed.
INTRODUCTION: The objective of this analysis was to evaluate differences in incidence of venous thromboembolisms (VTE) in critically ill trauma patients between pre- and post-implementation of updated VTE prophylaxis guidelines.
METHODS: This was a pre-post analysis of critically ill trauma patients receiving pharmacologic VTE prophylaxis. Trauma patients were included if they had an intensive care unit admission during their hospitalization. The primary outcome was incidence of detected VTE and was analyzed using a Chi-Squared test. A multivariate analysis assessed the effects of guideline implementation on VTE development when controlling for confounders.
RESULTS: There were 220 patients included. There was a significant increase in low molecular weight heparin use in initial (p ​= ​0.003) and final (p ​= ​0.004) prophylactic regimens between groups. There was no significant difference in VTE incidence between the pre and post groups (6.3% vs 1.9%, p ​= ​0.10). The multivariate analysis showed guideline implementation was independently associated with an 88% reduced odds of VTE (p ​= ​0.04).
CONCLUSION: This analysis suggests the updated VTE prophylaxis guideline implementation was associated with a trend toward reduced VTE development among critically ill trauma patients.
Neuroplasticity and inflammation represent a common final pathway for effective antidepressant treatment. SSRIs are the most commonly prescribed medications for depression and have demonstrated efficacy in reducing depressive symptoms. However, the precise impact of SSRIs on neuroplasticity and inflammation remains unclear. In this study, we aimed to investigate the influence of long-term treatment with SSRIs on hippocampal neuron, inflammation, synaptic function and morphology. Our findings revealed that fluoxetine treatment significantly alleviated behavioral despair, anhedonia, and anxiety in reserpine-treated mice. Moreover, fluoxetine mitigated hippocampal neuron impairment, inhibited inflammatory release, and increased the expression of synaptic proteins markers (SYP and PSD95) in mice. Notably, fluoxetine also suppressed reserpine-induced synapse loss in the hippocampus. Based on these results, fluoxetine has been demonstrated effectively to ameliorate depressive mood and cognitive dysfunction, possibly through the enhancement of synaptic plasticity. Overall, our study contributes to a further understanding of the mechanisms underlying the therapeutic effects of fluoxetine and its potential role in improving depressive symptoms and cognitive impairments.
This study was conducted at 2 hospitals in Purbalingga Regency and is a routine procedure carried out by researchers since 2015 and collected gradually from January to December 2023. The purpose of this study was to see the effectiveness and efficiency of several standard procedures carried out by the author for several years on post-spinal anesthesia complications and the duration of mobilization. In general, the effectiveness and efficiency of an action will lead to costs. This study was divided into 4 groups, namely the dose group based on height and weight with the ERACS method (A1), the dose group based on height and weight non-ERACS (A2), the dose group not based on height and weight with the ERACS method (K1), and the dose group not based on height and weight non-ERACS (K2). The total sample used was 150 which was divided into 2, namely 100 cases based on height and weight and 50 cases not based on height and weight. The sampling technique used the purposive sampling method. The study was conducted during January - December 2023.

This study compared the effectiveness between groups as seen from postoperative hemodynamics (blood pressure and pulse), duration of pain relief, and the use of perioperative resuscitation drugs (ephedrine) based on the patient\'s height and weight. In patients in groups A1 and A2, the administration of 0.5% bupivacaine is when the height is \> 150 cm, then the dose of bupivacaine is 10 mg and if the height is more than 160 cm, then the dose of bupivacaine is 15 mg. In groups K1 and K2, the administration of 0.5% bupivacaine is 20 mg. All statistical analyses were performed using IBM SPSS Statistics Software Version 20. The statistical tests used were the Wilcoxon Signed Ranks Test and the Kruskal Wallis Test adjusted to the needs and type of data. Data is considered significant if the p value is less than 0.05.
Consecutive patients who underwent PCI at a tertiary hospital (Mount Sinai Hospital, New York, NY, USA) between 2012 and 2020 with documented serum creatinine both pre- procedure and within 48 hours after PCI were identified from our existing prospectively populated database. Only patients who expired within 48 hours after PCI and with pre-existing end-stage renal disease requiring dialysis were excluded from the present analysis. CA-AKI was defined according to the Acute Kidney Injury Network as an increase by ≥50% or ≥0.3mg/dl within 48 hours after PCI compared to pre-PCI serum creatinine. Anemia was defined as hemoglobin plasma level ≤13 g/dl for men and ≤12 g/dl for women. Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) of ≤60 ml/min/1.73 m2, per the Chronic Kidney Disease-Epidemiologic (CKD-EPI) formula. A dedicated data coordinating center performed all data management. Prespecified clinical and laboratory demographic information was obtained from hospital charts that were reviewed by independent research personnel who were unaware of the objectives of the study; accumulated data were then entered prospectively in the database. Patients treated between 2012 and 2017 will comprise the derivation cohort (n=14,616) and those treated from 2018 to 2020 will form the validation cohort (n=5,606). Independent predictors of CA-AKI (defined per Acute Kidney Injury Network) will be derived from multivariate logistic regression analysis. Model 1 will include only preprocedural variables, while Model 2 will also include procedural variables. A weighted integer score based on the effect estimate of each independent variable will be used to calculate the final risk score for each patient. Impact on 1-year mortality of CA-AKI occurrence will be also evaluated with Cox regression analysis. Multivariable Cox regression analysis will be also performed to look for independent association of CA-AKI occurrence with mortality.
Antimicrobial films for generating singlet oxygen and their use is described. The antimicrobial films are generally thin films having two surfaces or faces. The first surface of the film is adhesive. Various adhesives, including, electrostatic charges, are possible. The second surface faces in a direction opposite from the first surface. The second surface of the film emits singlet oxygen when activated by light or ultrasound. Various photosensitizers can be incorporated onto the second surface of the films for generating the singlet oxygen. The singlet oxygen and other radical species generated from the antimicrobial films diffuses out from and in proximity to the films to form a layer or cloud of singlet oxygen at a concentration sufficient to inactivate microbial particles, e.g., viruses and other pathogens, that come within the singlet oxygen layer to provide a protective zone against microbial particles.
Robotic flexible ureteroscopy (RFURS) has shown encouraging results in terms of stone free rate (SFR) and better ergonomics compared to conventional FURS. However, few studies have reported its outcomes. The goal of this study was to report our initial results of RFURS, furthermore we proposed a novel metrics for composite outcome reporting named tetrafecta. A retrospective analysis of electronic records of 100 patients treated with RFURS for renal stones between 2019 till 2023 was performed. Tetrafecta criteria included, complete stone removal after a single treatment session, without auxiliary procedures, absence of high-grade complications (GIII-V) and same-day hospital discharge. Mean patient age and stone size were 40.7 ± 9.2 and 11.7 ± 5.8 mm, respectively. Median stone volume was 916 (421-12,235) mm3. Twenty-eight patients had multiple renal stones. Staghorn stones were seen in 12 patients. Preoperative DJ stent was fixed in 58 patients. Median operative time and stone treatment time were 116 min (97-148) and 37 (22-69) min. The median stone treatment efficiency (STE) was 21.6 (8.9-41.6). A strong positive correlation between stone volume and STE (R = 0.8, p < 0.0001). Overall, 73 patients were stone free after the initial treatment session while tetrafecta was achieved in 70 patients. Univariate analysis showed that the stone size (p = 0.008), acute infundibulopelvic angle (p = 0.023) and preoperative stenting (p = 0.017) had significant influence on achieving tetrafecta. Multivariate analysis identified preoperative stenting (OR 0.3, 95% CI 0.1-0.8, p = 0.019) as the only independent predictor of tetrafecta achievement. A comprehensive reporting methodology for reporting outcomes of RFURS is indicated for patient counseling and comparing different techniques. Tetrafecta was achieved in 70% of cases. Presence of significant residual stones ≥ 3mm was the leading cause of missing tetrafecta. Absence of preoperative stent was the only predictor of missing tetrafecta.
The invention belongs to the field of pharmaceutical chemistry and medicinal technology and relates to an indanone compound and its medicinal application. The invention provides the indanone compound as shown in the formula (I). in the formula (I), R1 is a hydrogen atom, a straight chain or branched chain alkyl group of 1-4 carbon atoms or 1-3 halogen substituted branched chain alkyl groups, halogen and trifluoromethyl groups; R2 is a hydrogen atom, a hydroxyl group, halogen, a trifluoromethyl group, a straight chain of 1-4 carbon atoms or branched chain alkoxy group; and R3 is a hydrogen atom, R4 is a hydroxyl group, or R3 and R4 are oxygen. It shows through results of pharmacological testing and animal experiments that the indanone compound has an effect of dose-dependently reducing expression of iNOS and IL-1beta in LPS-induced RAW264.7 cells. The inhibitory effect is realized by p38MAPK and JNK1/2 phosphorylation pathways. The result is that the indanone compound has an anti-inflammatory effect and can be used to prepare various preparations containing safe effective dose of the indanone compound and a medicinal carrier.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for treating the patients with recurrent thoracic esophagus cancer in esophageal-gastric anastomosis. Simultaneously, a double course of radiation and chemotherapy is conducted. A radiation therapy is conducted in the mode of a split course with a single basic dose daily 5 times a week with an interval between courses of 2–3 weeks. A recurrent esophageal tumor with subclinical submucosal areas is covered by irradiation zone 4–6 cm larger than the X-ray-determined tumor boundaries, as well as regional metastasis regions at a source-focus-tumor distance of 75 cm. If the upper esophageal involvement is exposed to one anterior field with the increased single basic dose. When the total focal dose of 40–45 Gy is reached, the radiation field boundary is increased by 2–3 cm. Chemotherapy is performed 2 hours before daily irradiation with oxaliplatin on 1st day of each course of radiation therapy, leucovorin + 5-fluoruracil from the first to the fifth days, bevacizumab once a week.EFFECT: method provides higher survival rate of patients with recurrent thoracic esophagus cancer due to a combination of radiation and polychemotherapy.8 cl
General anesthesia with propofol and remifentanil. (Total intravenous anesthesia) Infusion of dexmedetomidine (0.4 ug/kg/hr) during surgery. Administer rocuronium 0.8 mg/kg for induction.
Despite neutrophil involvement in inflammation and tissue repair, little is understood about their inflammatory status in acute coronary syndrome (ACS) patients with poor outcomes. Hence, we investigated the potential correlation between neutrophil inflammatory markers and the prognosis of ACS patients with/without diabetes and explored whether neutrophils demonstrate a unique inflammatory phenotype in patients experiencing an adverse in-hospital outcome. The study enrolled 229 ACS patients with or without diabetes. Poor evolution was defined as either death, left ventricular ejection fraction (LVEF) <40%, Killip Class 3/4, ventricular arrhythmias, or mechanical complications. Univariate and multivariate analyses were employed to identify clinical and paraclinical factors associated with in-hospital outcomes. Neutrophils isolated from fresh blood were investigated using qPCR, Western blot, enzymatic assay, and immunofluorescence. Poor evolution post-myocardial infarction (MI) was associated with increased number, activity, and inflammatory status of neutrophils, as indicated by significant increase of Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), fibrinogen, interleukin-1β (IL-1β), and, interleukin-6 (IL-6). Among the patients with complicated evolution, neutrophil activity had an important prognosis value for diabetics. Neutrophils from patients with unfavorable evolution revealed a pro-inflammatory phenotype with increased expression of CCL3, IL-1β, interleukin-18 (IL-18), S100A9, intracellular cell adhesion molecule-1 (ICAM-1), matrix metalloprotease (MMP-9), of molecules essential in reactive oxygen species (ROS) production p22phox and Nox2, and increased capacity to form neutrophil extracellular traps. Inflammation is associated with adverse short-term prognosis in acute ACS, and inflammatory biomarkers exhibit greater specificity in predicting short-term outcomes in diabetics. Moreover, neutrophils from patients with unfavorable evolution exhibit distinct inflammatory patterns, suggesting that alterations in the innate immune response in this subgroup may exert detrimental effects on disease progression.
In the combined nature-based and virtual mindfulness intervention, participants will complete the nature intervention followed by the mindfulness intervention. The virtual mindfulness intervention is 10 days long and offered online. Each day the participant will receive a notification that a new mindfulness audio is ready for viewing, which is from 10 to 25 minutes long. Mindfulness exercises include mindful breathing, body scan, and loving-kindness meditation. Participants can view the daily audio as many times as they wish but cannot view the next day's content to maintain treatment fidelity. At the end of each day, participants will be asked to indicate if they viewed the mindfulness audio to track adherence.
The active rTMS protocol is a 15-minute 10Hz stimulation, 10 seconds on, 20 seconds off, at 90% RMT, for a total of 3000 pulses using a real TMS coil. The target is the primary motor cortex.
Transcutaneous Electrical Acupoint Stimulation on Neiguan, Quchi, Zusanli, Sanyinjiao. Intensity: maximal tolerance by subject; Time span: 30minutes before anesthesia induction and 30 minutes after wound closure.