anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Galenic composition for topical use, and procedure for its preparation and use in the treatment of sore throat conditions. The invention relates to a galenic composition for topical use that comprises at least one glycerinated extract of plants and a thickener, in which said thickener is a combination of gelatin and gum arabic in a proportion greater than 7/1 by weight on the based on the total weight of the combination. The galenic composition according to the invention allows the oral topical application of glycerinated plant extracts so that they can exert their function locally and effectively on the oropharyngeal mucosa in the treatment of irritated throat conditions, as well as having an appearance and consistency. attractions that allow improved treatment adherence and safe administration, especially in childhood populations. The invention also relates to a procedure for preparing the galenic composition and its use for the treatment of sore throat conditions.  (Machine-translation by Google Translate, not legally binding)
To improve the sensitivity and specificity of immunoassay, the developing trends are to lower the detection threshold and to minimize the cross reaction. A new assay technology called immunomagnetic reduction (IMR) has been developed for rapid and on-site assay with very small volume of sample (i.e. less than 1ml whole blood). The reagent is a solution of homogeneously dispersed magnetic nanoparticles, which are coated with hydrophilic surfactants and bioprobes. Under external multiple alternating-current (ac) magnetic fields, magnetic nanoparticles oscillate with the multiple ac magnetic fields via magnetic interaction. The reagents under the external multiple ac magnetic fields show a magnetic property, called mixed-frequency ac magnetic susceptibility χac. Magnetic nanoparticles bind with the bioprobes on the outmost shell and become larger or clustered. The χac of the reagent is reduced, and the concentration of the biomolecules can be measured quantitatively. Several papers have demonstrated that IMR can be applied to assay proteins, viruses, chemicals, and nucleic acids once suitable bioprobes are immobilized onto the magnetic nanoparticles.

Rapid diagnosis of acute coronary syndrome (ACS) is a clinical and operational priority in busy emergency departments (ED). Since ACS is associated with a significant mortality and morbidity, early and correct diagnosis is of great importance. Chest pain is a frequent symptom in medical emergency departments and distinguishing patients with ACS within the chest pain group is a diagnostic challenge. Cardiac enzymes (including CPK/CK-MB, troponins, myoglobulin) and electrocardiography (ECG) in combination with the medical history and physical examination are at present the diagnostic cornerstones. Different cardiac enzymes are released after myocardial cell disintegration and are markers of cell necrosis, which might not be detected immediately after chest pain; and repeated measurements are suggested. Therefore novel biomarkers that rise earlier, have good diagnosis accuracy and have additional prognostic information are highly needed. Some publications address the potential benefit of the combination of multiple biomarker assays (markers of myocardial injury, inflammation/plaque ruptures or heart failure with different mechanism) could substantially increase clinical sensitivity and improve early risk stratification. However, this approach is rather time-consuming and not cost-effect. In the present study, a rapid IMR assay with multiple biomarkers is proposed and we will examine the performance of this new investigational IMR assays, comparison with current commercial assays.
The objective of the study is to determine the effects of mindfulness practice with strength training on pain, kinesiophobia and function among sprinters with patellofemoral syndrome. The study is randomized and single-blinded. Ethical approval is taken from ethical committee of Riphah International University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in group A \& B through sealed envelope method by Non-probability Convenient random sampling technique. Subjects in Group A will receive the strength training only. Group B will receive the mindfulness-exercise in addition to the strength training protocol. Usual pain, pain during stepping, and pain during running will be assessed using visual analog scales. Functional limitations of the knee will be assessed using the Knee Outcome Survey. Fear of movement, pain catastrophizing, and coping strategies will be measured via the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, and the Coping Strategies Questionnaire, respectively. For strength training we will use Muscle-strengthening Exercise Questionnaire Short Form (MSEQ). These outcomes will be assessed at baseline and after 6 weeks

The data will be analyzed by SPSS, version 25. Statistical significance is P=0.05.
All participants will undergo a 22 week dietary weight loss. In addition, participants will be asked to wear a weighted vest for \>10 hours a day. Weight in the vest is adjusted to match weight lost during the intervention.
<P>PROBLEM TO BE SOLVED: To provide a staining fluid for dental plaque quickly, easily and surely staining the dental plaque containing microorganisms relating to dental caries.  <P>SOLUTION: Stainability of the dental plaque is improved by bringing the dental plaque containing the caries-relating microorganisms into contact with the dental plaque staining fluid comprising an aqueous solution containing glycanase and an identifying staining agent for the caries-relating microorganisms, thereby partially decomposing a glycoside bond in the plaque with the glycanase to make the plaque fragile and promote impregnation of the identifying staining agent for the caries-relating microorganisms into the dental plaque. The glycanase is e.g. mutanase or dextranase, and the identifying staining agent for the caries-relating microorganisms is e.g. a redox dye such as a tetrazolium salt.  <P>COPYRIGHT: (C)2010,JPO&INPIT
AIMS: Endoprosthetic reconstruction following distal femur tumour resection has been widely advocated. In this paper, we present the design of an uncemented endoprosthesis system featuring a short, curved stem, with the goal of enhancing long-term survivorship and functional outcomes.
METHODS: This study involved patients who underwent implantation of an uncemented distal femoral endoprosthesis with a short and curved stem between 2014 and 2019. Functional outcomes were assessed using the 1993 version of the Musculoskeletal Tumour Society (MSTS-93) score. Additionally, we quantified five types of complications and assessed osseointegration radiologically. The survivorship of the endoprosthesis was evaluated according to two endpoints. A total of 134 patients with a median age of 26 years (IQR 16 to 41) were included in our study. The median follow-up time was 61 months (IQR 56 to 76), and the median functional MSTS-93 was 83% (IQR 73 to 91) postoperatively.
RESULTS: Overall, 21 patients (16%) encountered complications, and the rate of aseptic loosening was 7% (9/134). The survival rate up to 8.5 years was 93% for aseptic loosening as the endpoint, and 88% for any reason as the endpoint, retrospectively.
CONCLUSION: The use of an uncemented distal femoral endoprosthesis with a short, curved stem demonstrated a low incidence of aseptic loosening and achieved long-term survivorship of up to nine years. Meanwhile, aseptic loosening typically occurs in the early stage postoperatively.
Arrhythmias are irregular heartbeat rhythms caused by various conditions. Automated ECG signal classification aids in diagnosing and predicting arrhythmias. Current studies mostly focus on 1D ECG signals, overlooking the fusion of multiple ECG modalities for enhanced analysis. We converted ECG signals into modal images using RP, GAF, and MTF, inputting them into our classification model. To optimize detail retention, we introduced a CNN-based model with FCA for multimodal ECG tasks. Achieving 99.6% accuracy on the MIT-BIH arrhythmia database for five arrhythmias, our method outperforms prior models. Experimental results confirm its reliability for ECG classification tasks.
A one-group pretest-posttest design was adopted. Participants participated in 3 nutrition and exercise courses, each lasting 2 hours (including 1 hour nutrition course and 1 hour exercise course) with an interval of 1 week between each course. All subjects underwent anthropometric measurements and completed questionnaires one week before the start of the course and one week after the end of the course. A repeat assessment was conducted 6 months after the course intervention.
BACKGROUND: The influence of prebiotics and probiotics on oral microbiome composition, addressing dysbiosis, and aiding in the regulation of the immune-inflammatory response has recently been discussed. The objective of this scoping review is to explore current literature that examines the use of prebiotics and probiotics as adjunctive therapy for the treatment of periodontal disease with the intent to identify gaps in the literature to inform future research and dental hygiene practice.
METHODS: This review was conducted from December 2022 to August 2023 using the Arksey and O'Malley approach and PRISMA-ScR guidelines. Three databases were searched using combinations of keywords. Only peer-reviewed human/in vitro studies published in the last 10 years were included.
RESULTS: The search retrieved 204 articles. Duplicates were removed, titles and abstracts screened, and the full text of 80 articles examined, resulting in the inclusion of 19 articles.
DISCUSSION AND CONCLUSION: Most of the included literature indicated that probiotics have a positive impact on periodontal health as evidenced by changes in periodontal disease parameters. Future research should further examine various modes of administration and dosages. The effects of specific prebiotic and probiotic strains on specific pathogenic bacteria in conjunction with non-surgical periodontal therapy should also be further explored.
Patients were screened initially by measuring the length and thickness of the keloids using a ruler. Patients who met the study inclusion criteria were randomly divided into three groups. Each patient in the groups was given the same injection volume (1 mL) in every cm3 keloid volume using a 1 mL syringe and 27G needle. The injections were ultrasound-guided into the center of the lesion with a 30-45-degree angle using an in-plane technique, therefore the same pressure. Group 1 was given umbilical cord-derived mesenchymal stem cells (UC-MSC) 2 million cells/mL/cm3, group 2 was given umbilical cord-derived conditioned medium(UC-CM) 1 mL/cm3, and group 3 was given triamcinolone acetonide (TA) 40 mg/mL/cm3. All patients received a single dose and 1 booster dose. The percentage of keloid volume regression in each treatment group was calculated by calculating the difference in volume before and after therapy with a 3-dimensional CT-scan, then expressed as a percentage. The CT-scan volume was obtained with the SmartVitrea application (Figure 2), then a POSAS examination will be carried out for subjective and objective assessment.
Participants will receive a single oral dose of AB680 at one of two ascending dose levels. Assignment to receive AB680 will be random.
Background and Objectives: Cellulite, or edemato-fibro-sclerotic panniculopathy (EFP), is characterized by dermal and hypodermal changes leading to adipose tissue accumulation and compromised venous circulation. This study investigates the efficacy of a hypertonic cream containing concentrated sodium chloride (Jovita Osmocell®) in addressing water retention and structural alterations in adipose tissue, aiming to interrupt the cellulite formation process. Materials and Methods: A 12-week, prospective, monocentric, double-blind, placebo-controlled study enrolled 30 female subjects with grade II or III cellulite. Patients were randomized to receive hypertonic cream or a placebo. Thigh circumference, ultrasound evaluations, and standardized photographs were collected at baseline, intermediate, and endpoint visits. Adverse events were monitored. Results: After 84 days, the hypertonic cream group exhibited a significant reduction in thigh circumference compared to the placebo group (p = 0.0037). B-mode ultrasound examinations revealed significant changes in the parameters studied, such as the thickness of the subcutaneous tissue. No statistically significant changes were noticed in the placebo group. Volunteers reported the investigational product's pleasantness and good anti-cellulite activity, with no reported adverse events. Conclusions: The hypertonic cream demonstrated efficacy in reducing thigh circumference, addressing water retention and structural alterations in adipose tissue. The proposed mechanism involves osmosis, releasing accumulated fluids between fat cells, supporting drainage, and reducing inflammation. This study supports the efficacy and safety of hypertonic sodium chloride emulsions in cellulite treatment and confirms safety and user satisfaction.
INTRODUCTION: Several risk factors are associated with acute venous thromboembolism (VTE) after total joint arthroplasty (TJA). However, there is a lack of literature regarding the cumulative impact of multiple risk factors. To address this gap, we utilized the PearlDiver database, an insurance billing claims database containing de-identified data from 91 million orthopedic patients.
METHODS: The PearlDiver database was queried for records of patients who underwent total hip and knee arthroplasty from 2010 to 2019 using ICD-10 and CPT codes. Twelve persistent and two transient risk factors were analyzed for their association with the occurrence of acute VTE within three months after surgery. Univariate and logistic regression analyses with odds ratios (ORs) and confidence intervals (CIs) were conducted to determine the odds associated with each risk factor and the impact of multiple concurrent risk factors.
RESULTS: A total of 988,675 patients who underwent hip and knee arthroplasty met the inclusion criteria, of whom 1.5% developed acute VTE after three months. The prevalence of VTE risk factors ranged from 0.2 to 38.6%. Individual, persistent risk factors demonstrated 14-84% increased odds of VTE compared to a 1.2% increase for a transient risk factor (acute myocardial infarction). Three or more persistent risk factors were associated with a higher risk of VTE.
CONCLUSION AND RELEVANCE: Persistent risk factors were associated with a higher incidence of postoperative VTE than transient risk factors. An incremental increase in risk was noted if three or more persistent risk factors were present.
In this study, we expect to collect 10 sets of vertebrae (between T6 and L5) from 10 formalin-fixed human cadavers. The study protocol was reviewed and approved by the local Institutional Review Boards.The collected specimens subject to normalized Micro-CT and MSCT image scanning, image reconstruction using standard algorithms, and bone structure observation using bone algorithms to obtain high-quality, standardized axial images. We will use a conditional generation adversarial network-based image mapping technique to train the mapping model between MSCT images and Micro-CT images, find the correspondence between the image information contained in each of MSCT and Micro-CT, and finally obtain high-resolution micro-CT-like images. After obtaining the Micro-CT-like images of the samples, we will segment and annotate the images (including different structures such as vertebral body, bone cortex) and train the Teacher-Student \& U-Net++ deep learning architecture to achieve accurate segmentation of vertebral body regions, and obtain cancellous bone regions of interest. Based on this, we will analyze the bone structure characteristics of each spatial region in the images, including the thickness, spacing, orientation and distribution pattern of bone trabeculae and other indicators. Ultimately, we will cut a standardized cubic sample from the vertebral cancellous bone , obtain the bio-mechanical performance index of this cancellous bone sample by mechanical experiments, and analyze the correlation between bone structure of Micro-CT-like images and bio-mechanical index.
SAS is characterized by abnormality during sleep and hypoxemia from apnea and hypopnea, followed by systemic inflammation and organ dysfunction like cardiovascular diseases. Systemic inflammation causes the activation of arachidonic acid metabolism, producing prostaglandins (PGs) and leukotrienes (LTs). In addition, significant relationships between PGD2 and PGE2 and sleep, PGF2α and hypertension, PGI2 and thromboxane and platelet aggregation and so on are reported. Therefore, it is hypothesized that many prostanoids affect the pathophysiology of SAS. However, the relationships between prostanoids and clinical outcomes in patients with SAS are unknown. Although CPAP is the major treatment of SAS, the effects of CPAP on prostanoids are not known, either. Thus, the purpose of this study is to evaluate those relationships.
Group HH (heated-humidified) patients were administered 95% humidified CO2 insufflation at 37°C. All patients were given information and training on the anesthesia method, the use of the patient-controlled-analgesia (PCA) device and the visual analog scale (VAS) the day before the operation. The patients' demographic data (age, weight, height, etc.) and their basal systolic, diastolic and mean blood pressures and heart rates were measured prior to the operation and recorded on the case report form.
Risk Summary

The data with pirfenidone use in pregnant women are insufficient to inform on drug associated risks for major birth defects and miscarriage. In animal reproduction studies, pirfenidone was not teratogenic in rats and rabbits at oral doses up to 3 and 2 times, respectively, the maximum recommended daily dose (MRDD) in adults [see Data]. 

In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively.

Data

Animal Data

Animal reproductive studies were conducted in rats and rabbits. In a combined fertility and embryofetal development study, female rats received pirfenidone at oral doses of 0, 50, 150, 450, and 1000 mg/kg/day from 2 weeks prior to mating, during the mating phase, and throughout the periods of early embryonic development from gestation days (GD) 0 to 5 and organogenesis from GD 6 to 17. In an embryofetal development study, pregnant rabbits received pirfenidone at oral doses of 0, 30, 100, and 300 mg/kg/day throughout the period of organogenesis from GD 6 to 18. In these studies, pirfenidone at doses up to 3 and 2 times, respectively, the maximum recommended daily dose (MRDD) in adults (on mg/m2 basis at maternal oral doses up to 1000 mg/kg/day in rats and 300 mg/kg/day in rabbits, respectively) revealed no evidence of impaired fertility or harm to the fetus due to pirfenidone. In the presence of maternal toxicity, acyclic/irregular cycles (e.g., prolonged estrous cycle) were seen in rats at doses approximately equal to and higher than the MRDD in adults (on a mg/m2 basis at maternal doses of 450 mg/kg/day and higher). In a pre- and post-natal development study, female rats received pirfenidone at oral doses of 0, 100, 300, and 1000 mg/kg/day from GD 7 to lactation day 20. Prolongation of the gestation period, decreased numbers of live newborn, and reduced pup viability and body weights were seen in rats at an oral dosage approximately 3 times the MRDD in adults (on a mg/m2 basis at a maternal oral dose of 1000 mg/kg/day).
PURPOSE: To obtain an external preparation excellent in safety, having a moisture-retaining effect and an antiinflammatory effect, excellent in an antipruritic effect, and having suitability as the external preparation for the atopic dermatitis. CONSTITUTION: This external preparation for the atopic dermatitis contains the extract of one or more kinds of plants selected from the group of Tilia Europaea L., Melissa officinalis L., Trigonella foenumgraecum L., Borago officinalis L., Paris polyphylla Smith var. chinensis Franch., Pyrola japonica Kenze, Clerodendron cyrtophyllum Turcz, Pinellia cordata N. B. Br., and Clinopodium chinense (Benth.) O. Ktze., as an active ingredient.
PURPOSE: A pharmaceutical composition containing an Abutilon avicennae extract for preventing or treating inflammatory diseases is provided to suppress nitrogen oxide and nitric oxide synthase, and to treat rheumatoid arthritis or asthma. CONSTITUTION: A pharmaceutical composition for preventing or treating inflammatory diseases contains an Abutilon avicennae extract as an active ingredient. The extract is prepared from Abutilon avicennae leaves, fruits, roots, stems, seeds, seed coats, or a mixture thereof using an organic solvent, water, or a mixture thereof. A food composition for preventing or treating inflammatory diseases contains the Abutilon avicennae extract as an active ingredient. The inflammatory diseases include rheumatoid arthritis or asthma. A method for preparing the extract comprises a step of extracting Abutilon avicennae with the organic solvent, water, or a mixture thereof.
Patients receive paclitaxel IV over 3 hours on day 1 of each course. Treatment is repeated every 21 days for 6 courses in the absence of tumor progression or unacceptable toxicity. Quality of life assessments are conducted before treatment and at 2, 6, 9, and 12 months. Patients are followed every 3 months for 2 years, then every 6 months until disease progression or death.
Participants in the Kaletra Arm (Arm 1B) will be pregnant women who have CD4 counts of 200 cells/mm3 or more. As the intervention, they will receive Lamivudine/Zidovudine (3TC/ZDV) and Lopinavir/Ritonavir (LPV/RTV) twice daily. Once in labor, these participants will continue to take TZV twice daily and will also be given additional ZDV.
The method of anticellulite wrapping developed by Indrikson comprises the clinical examination of the patient, the assessment of the state of skin, diagnosing and treatment. Ex tempore, the mixture is prepared containing 20.0-80.0 mL of moistening cream, 5.0-20.0 mL of Capsicam gel, and 1.0-6.0 mL of caffeine solution. The mixture is rubbed by massaging into the area of cellulitis. Then these areas are wrapped into food-compatible film for 45 min. The film is removed, and the residual mixture is washed off the skin. The procedure is repeated once a week for 1-10 weeks. The results are assessed after each procedure. The treatment is continued until the positive effect.
This invention discloses a curcumin composition for increasing the bioavailability of curcumin, which consists of curcumin mixture and water extract in a ratio of 70:30. The curcumin mixture comprises curcumin dry crystals, volatile oil, fixed oil whereas water extract comprises soluble proteins, dietary fibers and carbohydrates extracted from turmeric. The composition also consists of a natural emulsifier isolated from  Quillaja saponaria  and lecithin. The composition increases rate of availability of curcumin as the dietary fibers holds the curcumin for long time. The soluble proteins increase the solubility of curcumin in water thus increasing absorption of curcumin in blood and the essential oil increases dispensability. The invention also discloses the method of preparation of the composition. The curcumin composition showed bioequivalence with 500 mg curcumin capsules, exhibited anti-aging, antioxidant, anti-inflammatory activities and is also effective in boosting the phagocyte mediated immunity suggesting as natural therapy for treatment of various diseases.