anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To speed up decision by bringing at least >=2 kinds among specific reagents prepd. by adsorbing a specific antibody to specific bacteria having possibility of bringing opportunistic infection into contact with a specimen soln. derived from a living body and detecting an antigen-antibody reaction. CONSTITUTION:13 Kinds of opportunistic infection bacteria are subjected to pure culture and after sterilization, the bacteria or the metabolism thereof is inoculated in an animal such as a domestic rabbit and antiserum is obtd. from the antibody formed in the animal body. The antiserum is subjected to an absorption operation to remove cross reaction and is refined to obtain the immune globulin G(IgG) in which the refined antibody exists. The IgG is adsorbed to an inactive carrier consisting of a spherical synthetic resin or red blood cells of an animal, by which the reagents shown in the table are obtd. The sample drawn from a lividing body is treated to obtain a sample soln. which is then brought into contact with the reagent. The antigen-antibody reaction of the case in which the antigen is contained in the sample is observed or measured.
Eight (8) current or former crack users will be recruited to facilitate small networks of crack users in a three-day intervention. They will also facilitate monthly meetings open to all community members regarding HIV prevention and interpersonal violence.
Intervention: Participants randomized to the eFIT condition will join a 1-hour peer group meeting online each week, called eFIT intervention. They will learn about accountability partners, and use the group as an accountability partner to state and attain physical fitness goals.
PCT No. PCT/JP97/01667 Sec. 371 Date Nov. 20, 1998 Sec. 102(e) Date Nov. 20, 1998 PCT Filed May 19, 1997 PCT Pub. No. WO97/44034 PCT Pub. Date Nov. 27, 1997A rosacea treating agent is provided, which is effective even on intractable rosacea which cannot be cured completely by antibiotics such as minocycline, has low toxicity, causes little side effect, and is of long duration. The rosacea treating agent of the present invention comprises, as an active ingredient, at least one selected from the group consisting of benzoheterocyclic derivatives represented by the following formula (1): wherein R is a lower alkyl group; and X is a halogen atom, and salts thereof.
BACKGROUND: Bell's mania was first described in 1849, and other terms have been used to describe this condition, including delirious mania, mania with delirium, and excited delirium. However, no international diagnostic manual has included mania as an independent diagnostic tool. The criteria for delirious mania were proposed by Bond et al.
METHODS: We present a case of a man without a personal or family psychiatric history who experienced his first manic episode of delirium and psychosis at 76 years old.
CONCLUSIONS: The case described in this study is compatible with mood disorders, the original description of Bell's mania, and Bond's definition of delirious mania. Although rare, extremely late-onset primary mania can occur without personal or family psychiatric history. The initial clinical presentation of delirium requires a thorough medical investigation, including magnetic resonance imaging (MRI) and lumbar puncture with neuronal antibodies. The addition of delirious mania to the group of bipolar disorders in future editions of The International Classification of Diseases (ICD) and Diagnostic and Statistical Manual of Mental Disorders (DSM) has therapeutic and prognostic implications. The Bond criteria can provide valuable information in this respect. Further investigations are necessary to clarify the pathophysiology and epidemiology of delirious mania.
PURPOSE: To obtain a composition comprising a cationic antibacterial substance, a nonionic thickener, a surfactant and an abrasive and useful for prevention and/or treatment of periodontal disease, dental calculus and caries. CONSTITUTION: This composition comprises (A) a bacteriostatically effective amount of a cationic antibacterial substance, e.g. a quaternary ammonium salt, a pyridinium compound or a pyrimidine derivative, (B) a nonionic thickener, e.g. an alkylcellulose ether, (C) a nonionic, cationic or ampholytic surfactant or a mixture thereof and (D) an abrasive comprising a sparingly soluble salt combined with a substance suppressing formation of an anion (a water-soluble salt containing a cation forming insoluble or sparingly soluble salt together with an anion of the abrasive), e.g. calcium carbonate or insoluble compound (e.g. silica or plastic particles) or a mixture thereof.
XROMI (hydroxyurea) is an antimetabolite available for oral use as oral solution containing 100 mg/mL hydroxyurea. Inactive ingredients include methyl parahydroxybenzoate, purified water, sodium hydroxide, strawberry flavor, sucralose and xanthan gum.  
  
Hydroxyurea is a white to off-white crystalline powder. It is hygroscopic and freely soluble in water, but practically insoluble in alcohol. The empirical formula is CH4N2O2 and it has a molecular weight of 76.05. Its structural formula is:
People with serious mental illness admitted to hospital face significant barriers to gain both education and employment. Norway is a high-income welfare society with low unemployment rates, but the employment rates are very high in the population with psychosis and schizophrenia. Norway have a strategy for work and mental health, and through this strategy, the government has supported some pilot projects which focus on new ways of supporting people with serious mental illness in gaining employment. This study focuses on a representative sample participating in a pilot study. The sample consists of admitted patients who have received vocational rehabilitation under admittance. The study design is qualitative in nature with open- ended questions to allow the sample to express their opinions, attitudes and thoughts about the assistance they have had during their rehabilitation stay in hospital.
BACKGROUND: Obesity is a driver of multimorbidity. Knowledge regarding individual and population based solutions is evolving in primary care. Stigma/self-stigma are important in developing clinical solutions. Inquiry based stress reduction (IBSR) is emerging as a solution for self-stigma in a range of conditions. This study explores IBSR (also known as The Work of Byron Katie) in obesity self-stigma in the GP setting, with severe obesity, utilising a multidisciplinary approach.
AIM: Is it feasible/acceptable to utilise Inquiry Based Stress Reduction in the GP setting for obesity?
METHOD: Mixed-method pilot study including a convenience sample of people with severe spectrum obesity from a three-doctor general practice, including use of IBSR provided in both group, partner and individual settings, predominantly online, utilising certified and accredited IBSR facilitators, a clinical psychologist, and participating GPs. Outcomes include pre- and post-intervention surveys (Becks Depression Scale, HRQoL, Weight Bias Internalisation Scale, Weight Self-stigma Questionnaire) and qualitative data from participants.
RESULTS: Of 22 initially invited to participate, 14 commenced and 10 completed the intervention. Mean BMI was 42.8, mean age 49 years, female:male = 7:3. Many believed obesity was their own fault, related very difficult interactions with healthcare professionals, and valued opportunity to engage with the intervention. While participants had alarming levels of comorbidity, they were far more concerned regarding stigma and self-stigma.
CONCLUSION: Results and experience in practice indicate this approach is feasible and acceptable. Results are valuable in planning a larger study in multiple practices.
BACKGROUND: Health care-associated infections (HAIs) can affect patient safety and recovery. Musical instruments used by music therapy services may carry pathogens, particularly in ICUs. The aim of this study was to determine the efficacy of the cleaning and disinfection protocol by the music therapy service of the University Hospital Fundación Santa Fe de Bogotá.
METHODS: This prospective cohort study included all ICU music therapy patients from July to August 2023. Adenosine triphosphate (ATP) bioluminescence tests and microbiological cultures were taken before and after cleaning the musical instruments for nine patients in the adult and pediatric ICUs. ATPs were taken before starting music therapy, after finishing music therapy, and after cleaning the instruments. Cultures were taken if an ATP test was above the established cutoff of ≤ 200 relative light units (RLUs). If no ATP value was above the cutoff, cultures were taken randomly.
RESULTS: A total of 63 ATPs and 10 random microbiological cultures were taken. After applying the cleaning and disinfection protocol, all ATP values were ≤ 200 RLUs. Of the 10 microbiological cultures, 1 screened positive for Streptococcus sp., yeast, and Micrococcus. One hundred ICU music therapy patients were followed up, and positive associations with HAIs were found for age (p = 0.01), type of unit (p = 0.001), tracheostomy (p < 0.001), arterial line (p = 0.005), hemodialysis catheter (p = 0.05), bladder catheter (p = 0.02), number of invasive devices (p = 0.02), duration use of invasive devices (p = 0.01), and days of hospitalization (p = 0.01). Number of music therapy sessions/patient was not associated with HAIs (p = 0.86).
CONCLUSION: The results indicate that the current cleaning and disinfection protocol can be considered safe and effective. To the authors' knowledge, this is one of the first studies investigating biosafety of musical instruments in a hospital-based music therapy service. Patient safety is of the utmost importance in hospital settings, and awareness about proper cleaning of their work tools among music therapists is paramount.
PROBLEM TO BE SOLVED: To obtain the subj ect new compound having excellent suppressing activity against the death of neurocyte causing apotosis promotion in nerve system and useful as an agent for the prevention and treatment of nervous diseases such as Alzheimer's disease and peripheral nerve disorder. SOLUTION: The objective compound is expressed by the formula I [Ar is a (substituted) aromatic group or a (substituted) heterocyclic group; (n) is 0-2; R<1> is a substituent selected from H, nitro and aminol, e.g. 5-(4- nitrophenylsulfanyl) isoquinoline. The compound can be produced by reacting a compound of the formula II with a compound of the formula Y-Ar (Y is a halogen or a diazonium halide) in a solvent usually dimethylformaldehyde at a temperature between room temperature and the thermal refluxing temperature. A base such as KOH or NaOH is preferably added to the system to accelerate the reaction. The compound of the formula I wherein n=0 is produced by the reaction and the product is oxidized with an oxidizing agent (e.g. H2 O2 or organic peroxide) to form an isoquinoline derivative of the formula I wherein n is 1 or 2 and its pharmacologically permissible acid addition salt.
Approximately 90% of esophageal cancers in Japan are squamous cell carcinomas, and they are often detected at earlier stages in Japan than in Western countries; superficial esophageal cancer without lymph node or distant metastasis comprises one-third of all esophageal cancers in Japan. Endoscopic resection is a minimally invasive treatment for superficial esophageal cancer; however, the risk of regional lymph node recurrence is negligible when it invades the submucosal layer or lymphovasculature. In such cases, surgical treatment is necessary to control regional lymph node recurrences, although the physical burdens and potential complications cannot be overlooked. Recently, clinical trials in Japan have shown promising clinical outcomes of organ preservation strategies. One strategy is initially performing endoscopic resection for superficial esophageal cancer, assessing the risk of lymph node metastasis based on pathological diagnosis for endoscopically resected specimens, and subsequently considering additional therapy (e.g., observation or prophylactic chemoradiotherapy)-another strategy aimed to cure superficial esophageal cancer through definitive chemoradiotherapy alone. The safety and efficacy of the two strategies have been evaluated in clinical trials, which showed that both organ preservation strategies are comparable to surgery in terms of overall survival. However, challenges include improving the accuracy of pretreatment endoscopic diagnosis and decreasing the local-regional recurrence after chemoradiotherapy. This review provides an overview of the latest standard treatment for early-stage esophageal cancer and its future perspectives.
PURPOSE:To obtain a hair growth agent having excellent hair growth effects and ultrahigh safety with hardly any irritation to the skin without any side effects. CONSTITUTION:This hair growth agent comprises an ingredient obtained from an extract solution, a pressed juice, a sap, etc., of Lagenaria leucantha Rusby var. clavata Makino. The ingredient of the Lagenaria leucantha Rusby var. clavata Makino is obtained from an extract solution prepared by extracting the Lagenaria leucantha Rusby var. clavata Makino or a dried substance thereof with a solvent such as water, alcohols, ketones, ethers or chloroform or a mixed solvent thereof, the pressed juice obtained by chopping the Lagenaria leucantha Rusby var. clavata Makino and pressing the chopped Lagenaria leucantha Rusby var. clavata Makino with a filter press, etc., or the sap prepared by cutting a vine of the Lagenaria leucantha Rusby var. clavata Makino during the cultivation and collecting the dripped sap. The solution or liquid containing the ingredient of the Lagenaria leucantha Rusby var. clavata Makino is directly used or diluted or concentrated to a suitable concentration and daily directly applied to the skin about once to twice. The existing effective substance, e.g. a peripheral vasodilator or an antiinflammatory agent in an adequate amount may be contained therein for use.
Electro-acupuncture will be conducted for 2 sessions per week over 6 consecutive weeks. Disposable acupuncture needles (0.30 mm in diameter and 25-40 mm in length) are inserted at a depth of 10-30 mm obliquely into scalp acupuncture points (Baihui, Toulinqi) or straightly into body acupuncture points (Taichong, Zhangmen, Sanyinjiao, Zhongwan, Guanyuan, Tianshu, Zusanli). Electroacupuncture will be applied to the abdominal points at fast and dispersed waves through electric needle stimulator (ES-160 6-Channel Programmable Electro-acupuncture) for 30 min. The intensity is adjusted to a level at which patients feel comfortable.
One cycle of therapy will be defined as 3 weeks (21 days). Perifosine 50 mg qd (Days 1-21) + Capecitabine 1000 mg/m2 BID (Days 1-14).
Interest to the tissue-specific intestinal isoenzyme of alkaline phosphatase (IAP) has increased in recent years due to eating disorders that have led to widespread obesity and diet-related diseases. Obesity is considered as an inflammation of low intensity, which is accompanied by the manifestation of various metabolic complications and a disturbance of intestinal homeostasis. IAP is one of the participants in the mechanism of the macroorganism protection against inflammatory and infectious processes, carrying out enzymatic detoxification of bacterial lipopolysaccharide (the trigger of the inflammatory process). Deficiency of IAP activity contributes to the risk of obesity, inflammatory diseases. The objective of the research was to summarize the current understanding of the role of IAP involved in the molecular mechanism of diet-induced obesity and to evaluate the impact of dietary components - fats and dietary fiber on IAP activity. Material and methods. A literature search on the role of IAP in the development of obesity was carried out using PubMed, Scopus, Web of Science, Google Scholar, ResearchGate, RSCI databases. Results. IAP prevents the development of the inflammatory process by participating in the detoxification of toxic bacterial products, limiting the translocation of pathogenic bacteria from the intestine to various tissues and organs of the macroorganism. The enzyme maintains the integrity of the intestinal barrier, influencing the synthesis and proper localization of tight junction's proteins between intestinal epithelial cells, promotes changes in the composition of the microbiota, decreasing pathogenic bacteria and increasing the population of the community of beneficial microorganisms. IAP is involved in the regulation of fatty acid absorption and influences on the adipogenesis. Monitoring the activity of IAP present in human stool can predict the early development of such complications associated with obesity as metabolic syndrome and diabetes mellitus, Some nutrients modulate IAP activity. Depending on the amount, type, composition of fats and the duration of their consumption, either an increase or decrease in the IAP activity are observed, while dietary fibers stimulate the activity of the enzyme. Conclusion. IAP activity can be considered as an early predictor of the risk of obesity. Deficiency of IAP activity contributes to the development of obesity caused by high-fat diet. The high activity of the enzyme contributes to the support of intestinal homeostasis and limits transepithelial movement of bacteria, weakening the inflammatory process induced by lipopolysaccharides, the excess concentration of which is detected in obesity. Stimulating enzyme activity through dietary intervention reduces the risk of obesity and metabolic complications.
The day before their scheduled appointment, participants will receive a message describing the pro-social benefits of getting a flu shot, and a reminder to ask for their flu shot. The described pro-social benefits will vary whether they emphasize the COVID-19 pandemic (e.g., protecting loved ones from the risk of hospital-acquired COVID-19 infection) or not (e.g., protecting loved ones from serious complications from the flu). Participants will also receive a reminder message on the day of the appointment.
Treatment of a degenerative disease of the articular cartilage comprises administering (t)-catechin (trans-2-(3,4-dihydroxyphenyl) 3,4-dihydro- 3H-1-benzopyran 3,5,7-triol) (I) pref. (I) is administered at daily doses 1-4g orally or rectally; 5-50 mg intra-articularly or intravenously; or 100 mg-2g topically. (I) inhibits the spontaneous degradation of the proteoglycans from rabbit ear cartilage; increases the in vitro fibrillation of collagen extd. from rat skin; increases, in the presence of beta-aminorpopionitrile (II), the proportion of insoluble collagen produced by fibroblasts and restores a normal ratio between alpha and beta collagen chains but, in the absence of (II), does not quantitatively effect protein or collagen synthesis; inhibits in vitro degradation of collagen fibres by collagenase; and inhibits PGE 2 synthesis (antiflammatory activity). The method is esp. for treating osteoarthritis, chondromalacia and degenerative processes of the articular cartilage caused by other diseases e.g. theumatoid arthritis.
Eye Movement Desensitization and Reprocessing (EMDR) therapy will be administered face-to-face by a psychotherapist in a total of 12 sessions, with one session per week. The efficacy of EMDR therapy will be compared with Cognitive Behavioral Therapy (CBT) in the treatment of Post-Traumatic Stress Disorder (PTSD) in Pakistan.
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD.
MATERIALS AND METHODS: A convolutional neural network was trained using manually corrected, filter-based segmentations (n = 1000) to automatically segment the PVS in the centrum semiovale from interpolated, coronal T2-weighted magnetic resonance imaging scans (n = 894). These scans were sourced from the national German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study. Convolutional neural network-based segmentations and those performed by a human rater were compared in terms of segmentation volume, identified PVS clusters, as well as Dice score. The comparison revealed good segmentation quality (Pearson correlation coefficient r = 0.70 with P < 0.0001 for PVS volume, detection rate in cluster analysis = 84.3%, and Dice score = 59.0%). Subsequent multivariate linear regression analysis, adjusted for participants' age, was performed to correlate PVS volume with clinical diagnoses, disease progression, cerebrospinal fluid biomarkers, lifestyle factors, and cognitive function. Cognitive function was assessed using the Mini-Mental State Examination, the Comprehensive Neuropsychological Test Battery, and the Cognitive Subscale of the 13-Item Alzheimer's Disease Assessment Scale.
RESULTS: Multivariate analysis, adjusted for age, revealed that participants with AD and MCI, but not those with SCD, had significantly higher PVS volumes compared with CU participants without SCD ( P = 0.001 for each group). Furthermore, CU participants who developed incident MCI within 4.5 years after the baseline assessment showed significantly higher PVS volumes at baseline compared with those who did not progress to MCI ( P = 0.03). Cognitive function was negatively correlated with PVS volume across all participant groups ( P ≤ 0.005 for each). No significant correlation was found between PVS volume and any of the following parameters: cerebrospinal fluid biomarkers, sleep quality, body mass index, nicotine consumption, or alcohol abuse.
CONCLUSIONS: The very early changes of PVS volume may suggest that alterations in PVS function are involved in the pathophysiology of AD. Overall, the volumetric assessment of centrum semiovale PVS represents a very early imaging biomarker for AD.
Technologies are provided for implementing an interpretation bias modification (IBM) therapy using a mobile device. Some embodiments include a computing device that can initiate a session for interpretation bias modification (IBM) therapy, and can present, as part of the session, a statement describing an ambiguous anger-provoking situation. The computing device also can present, as part of the session, a second statement that comprises a non-threatening interpretation of such situation. That interpretation can be presented in natural language and missing at least one character. The computing device also can receive input defining one or more characters, and can determine that the one or more characters correspond to the at least one character missing in that interpretation. The computing device can then present, as part of the session, a comprehension question corresponding to the non- threatening interpretation, and can prompt selection of an answer to the comprehension question to reinforce the non-threatening interpretation.
Group A: up to 275 health care workers who choose to take hydroxychloroquine. Will receive a 600 mg loading dose, followed by 200 mg daily (tablets).
Participants received pegozafermin 27 mg QW as an SC injection for 8 weeks in the Main Study cohort or Fibrate Expansion cohort. Main Study and Fibrate Expansion pegozafermin 27 mg QW groups were pooled together due to low sample size in the expansion cohort.