anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Exposure to traumatic events, such as automobile accidents and physical or sexual assault, can cause individuals to develop persistent psychological difficulties such as post-traumatic stress disorder (PTSD). PTSD is an anxiety disorder characterized by avoidance, hyperarousal symptoms, and mental re-experiencing of the traumatic event. PTSD is a serious condition that may cause social and psychological impairment; therefore, safe and effective treatments are needed. Both CBT (cognitive behavior therapy) and antidepressant therapy have been shown to effectively treat PTSD symptoms; however, comparisons of the treatments are limited. This study will compare the short- and long-term effectiveness of prolonged exposure and prolonged exposure plus the antidepressant sertraline.

Participants will either be randomly assigned to prolonged exposure (PE) or PE plus sertraline, or they will be able to choose one of the two treatments,which will be given for 10 weeks, followed by 9 months of follow-up assessments. Participants in the PE group will have 10 weekly sessions of therapy. During the therapy sessions, participants will be encouraged to confront their general fears and the memory of their trauma through repeated storytelling. Participants will also be encouraged to practice the techniques learned in therapy in everyday life. Participants in the PE plus sertraline group receive the same treatment as the PE group plus they will take sertraline daily for 10 weeks. These participants will be seen regularly by a psychiatrist who will offer general encouragement and support, monitor response to medication, and record any side effects participants may be experiencing. The medication may be adjusted according to a dosing schedule and based on the study doctor's judgment. At the end of 10 weeks, participants in the PE plus sertraline group will have the choice of either tapering the medication gradually to minimize the chance of withdrawal symptoms or staying on the medication for up to 9 months. Participants who do not respond to their assigned or chosen treatment will be offered booster sessions or the other treatment for 10 weeks. Self-report scales and questionnaires will be used to assess participants' PTSD symptoms, depression, anxiety, and social functioning. These assessments will occur at 3, 6, and 9 months after the study treatment period.
The main purpose of this study is to collect pilot feasibility study data for the use of low dose propranolol for helping treat fibromyalgia. The investigators plan to compare 20mg twice a day dosage of propranolol and 10mg twice a day dosage of propranolol to placebo. The design is a 3 arm, double blind randomized control trial. The investigators will also test ECG and respiratory assessment as a part of the safety screening and the feasible assessment of respiratory sinus arrhythmia.

Propranolol is not indicated to treat pain. However, the previous studies showed that low dose propranolol can re-regulate the adrenergic dysfunction and reduce pain in people with chronic musculoskeletal pain. However, the investigators are not aiming to develop a new indication of the drug.
This group will include 40 patients with MDD who will be treated with acupuncture and SSRIs antidepressants. Strong reaction acupoints selected in the first part of the study will be stimulated. The oral dose of SSRIs antidepressants will be determined by the clinical specialist.
Two-thirds of participants will be assigned to the RTI Tier 1 Arm. Teachers of students in this arm will receive consultation in RTI Tier 1 Classroom Management strategies.
Disclosed embodiments provide cognitive state evaluation for vehicle navigation. The cognitive state evaluation is accomplished using a computer, where the computer can perform learning using a neural network such as a deep neural network (DNN) or a convolutional neural network (CNN). Images including facial data are obtained of a first occupant of a first vehicle. The images are analyzed to determine cognitive state data. Layers and weights are learned for the deep neural network. Images of a second occupant of a second vehicle are collected and analyzed to determine additional cognitive state data. The additional cognitive state data is analyzed, and the second vehicle is manipulated. A second imaging device is used to collect images of a person outside the second vehicle to determine cognitive state data. The second vehicle can be manipulated based on the cognitive state data of the person outside the vehicle.
Ointment for treating blister type beriberi and a preparing method thereof are disclosed. The blister type beriberi usually is beriberi in an acute developing period, begins abruptly, and is serious in summer and mild in winter. Primary lesions mainly comprise phlyctenules. The phlyctenules are in groups or sporadic, thick in wall and clear in blister fluid and are commonly seen between toes, on the sole heart and on foot side border. The phlyctenules are below the epidermal stratum corneum. As the stratum corneumin of vola pedis parts is thick, the phlyctenule wall is not liable to perforate and surrounding skin is free of flush. The ointment is prepared from following raw materials by weight: 3-5 parts of Chinese dittany bark, 6-8 parts of lysimachia christinae hance, 6-8 parts of origanum vulgare, 8-10 parts of myrrh, 8-10 parts of sargentgloryvine stem, 4-6 parts of chastetree fruit, 4-6 parts of atractylodes macrocephala, 3-5 parts of erycibe obtusifolia, 10-12 parts of chitosan, 70-80 parts of vaseline and 40-50 parts of glycerol. Medicine effects of components are synergistic. The ointment has obvious treating effects for the blister type beriberi.
Vaccines suitable for oral administration to domestic animals comprises an aqueous vehicle containing a live but attenuated metazoan endoparasite which is pathogenic to domestic animals and is a nematode, trematode or cestode in the form of eggs or a pre-migratory or a migratory immature form.  Attenuation, defined as being the deprivation of its pathogenic but not its antigenic properties, may be accomplished by subjecting the endoparasite to ionizing radiation, e.g. X-rays, the radiation of cobalt 60.  The irradiated organisms may be suspended in an aqueous vehicle, e.g. physiological saline solution, for use as a vaccine.  Specified metazoan endoparasite are Dictyocaulus viviporus, Fasciola, gigantica, Taenia saginata, Ascaris lumbricoides, Fasciola hepatica, Nematodirus, Haemonchus contortus.
The analogy between the brain and deep neural networks (DNNs) has sparked interest in neuroscience. Although DNNs have limitations, they remain valuable for modeling specific brain characteristics. This study used Skye's Oblique Grating illusion to assess DNNs' relevance to brain neural networks. We collected data on human perceptual responses to a series of visual illusions. This data was then used to assess how DNN responses to these illusions paralleled or differed from human behavior. We performed two analyses:(1) We trained DNNs to perform horizontal vs. non-horizontal classification on images with bars tilted different degrees (non-illusory images) and tested them on images with horizontal bars with different illusory strengths measured by human behavior (illusory images), finding that DNNs showed human-like illusions; (2) We performed representational similarity analysis to assess whether illusory representation existed in different layers within DNNs, finding that DNNs showed illusion-like responses to illusory images. The representational similarity between real tilted images and illusory images was calculated, which showed the highest values in the early layers and decreased layer-by-layer. Our findings suggest that DNNs could serve as potential models for explaining the mechanism of visual illusions in human brain, particularly those that may originate in early visual areas like the primary visual cortex (V1). While promising, further research is necessary to understand the nuanced differences between DNNs and human visual pathways.
487,097. Depilating skins. WALLERSTEIN CO., Inc. May 28, 1937, No. 14832. Convention date, June 26, 1936. [Class 76] Hides and skins are depilated by treatment with an alkaline material, e.g. lime or caustic alkali, with the addition of hydrosulphites, sulphoxylates or their organic derivatives. Additional agents such as amines, sulphides of sodium and arsenic and proteolytic enzymes may also be present, e.g. after treatment in a solution of caustic soda and sodium formaldehyde hydrosulphite or sulphoxylate the bath may be partially neutralized and a bacterial enzymatic solution added. Antiseptic agents may be added to the baths.
In this arm participants will receive usual postpartum care. They will be discharged from the hospital while their baby is still in the NICU and a plan will be made to for follow-up with their provider as an outpatient at some point in the next 6 weeks. The study coordinator will provide the participant with a community postpartum resources list.
Prostatic Cancer

Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently co-exist. Therefore, patients thought to have BPH should be examined prior to starting terazosin therapy to rule out the presence of carcinoma of the prostate.

Intraoperative Floppy Iris Syndrome (IFIS)

Intraoperative Floppy Iris Syndrome (IFIS) has been observed during cataract surgery in some patients on/or previously treated with alpha-1 blockers. This variant of small pupil syndrome is characterized by the combination of a flaccid iris that billows in response to intraoperative irrigation currents, progressive intraoperative miosis despite preoperative dilation with standard mydriatic drugs, and potential prolapse of the iris toward the phacoemulsification incisions. The patient's ophthalmologist should be prepared for possible modifications to their surgical technique, such as the utilization of iris hooks, iris dilator rings, or viscoelastic substances. There does not appear to be a benefit of stopping alpha-1 blocker therapy prior to cataract surgery.

Orthostatic Hypotension

While syncope is the most severe orthostatic effect of terazosin (see WARNINGS), other symptoms of lowered blood pressure, such as dizziness, lightheadedness and palpitations, were more common and occurred in some 28% of patients in clinical trials of hypertension. In BPH clinical trials, 21% of the patients experienced one or more of the following: dizziness, hypotension, postural hypotension, syncope, and vertigo. Patients with occupations in which such events represent potential problems should be treated with particular caution.
Heparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Heparin acts at multiple sites in the normal coagulation system. Small amounts of heparin in combination with antithrombin III (heparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of heparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor. Heparin does not have fibrinolytic activity; therefore, it will not lyse existing clots.
FIELD: medicine. ^ SUBSTANCE: group of inventions concerns medicine and covers normalisation of sleep/wakefulness cycle in a mammal, and also to increasing its cognitive function. It involves introduction of therapeutically effective amount of the compound chosen from the group including cytosine, cytidine, cytidine monophosphate, cytidine triphosphate, deoxycytidine monophosphate, deoxycytidine diphosphate or deoxycytidine triphosphate, cytidine diphosphate - choline, cytidine diphosphate sodium choline, uridine, uridine triphosphate, uridine diphosphate, uridine monophosphate and triacetyluridine. Said mammal does not suffer from insomnia. ^ EFFECT: offered methods reduce asthenia or fatigue during a day, improve sleep quality, besides, they can be used in treatment of somnipathies, including sleep apnea, periodic limb movements, a restless leg syndrome, narcolepsy and somnolency problem, or in increasing cognitive functions in the sleep deprived patients. ^ 18 cl, 3 dwg
PURPOSE: A Viscum album extract with anti-obesity is provided to prevent fatty liver and to be used in functional foods or medicines. CONSTITUTION: A Viscum album extract has antiobesity efficiency and fatty liver prevention. The Viscum album extract is prepared by cold water or hot water extraction. The cold water extract of Viscum album is prepared by mixing 1L of water and 200g of Viscum album, stirring at 4°C for two hours. The hot water extract is prepared by mixing 1L of water and 200g of the residue of the cold water extract and heating at 100°C for 30 minutes. A functional food composition or pharmaceutical composition for anti-obesity or fatty liver prevention contains the Viscum album extract as an active ingredient. The pharmaceutical composition is manufactured in the form of a table, pill, granule, liquid phase or capsule by containing a carrier or excipient.
In the study, it is aimed to evaluate the effect of virtual game simulation on the diagnosis and goal setting skills of first year nursing students. For this purpose, the research will be conducted with first-year nursing students who meet the criteria for participation in the research and agree to participate in the study. Ethics committee permission and institutional permission were obtained from the relevant institution before starting the study. In the study, students will be randomly divided into control and intervention groups. Randomization and evaluation of the results will be performed by those other than the researchers, thus providing triple blinding in the study. First of all, the theoretical course content of the nursing process prepared by the researchers in the classroom environment will be explained to the control group students and the intervention group students. Then, it will be applied to the control group students with pencil and paper in the Chronic obstructive pulmonary disease case, which consists of an educational appendectomy document and an evaluation test in the classroom environment. The students of the intervention group will play the virtual game simulation in the computer classroom of the school where the study will be conducted, in the same way as the cases applied to the control group. The effect of the simulation game on diagnosis and goal creation will be determined. At the end of the study, simulation games will be played to the students in the control group and all other students in the class who were not included in the study.
Oleocanthal (OC) is a monophenol of extra-virgin olive oil (EVOO) endowed with antibiotic, cardioprotective and anticancer effects, among others, mainly in view of its antioxidant and anti-inflammatory properties. OC has been largely investigated in terms of its anticancer activity, in Alzheimer disease and in collagen-induced arthritis; however, the possibility that it can also affect muscle biology has been totally overlooked so far. This study is the first to describe that OC modulates alterations induced in C2C12 myotubes by stimuli known to induce muscle wasting in vivo, namely TNF-α, or in the medium conditioned by the C26 cachexia-inducing tumor (CM-C26). C2C12 myotubes were exposed to CM-C26 or TNF-α in the presence or absence of OC for 24 and 48 h and analyzed by immunofluorescence and Western blotting. In combination with TNF-α or CM-C26, OC was revealed to be able to restore both the myotube's original size and morphology and normal levels of both atrogin-1 and MuRF1. OC seems unable to impinge on the autophagic-lysosomal proteolytic system or protein synthesis. Modulations towards normal levels of the expression of molecules involved in myogenesis, such as Pax7, myogenin and MyHC, were also observed in the myotube cultures exposed to OC and TNF-α or CM-C26. In conclusion, the data presented here show that OC exerts a protective action in C2C12 myotubes exposed to TNF-α or CM-C26, with mechanisms likely involving the downregulation of ubiquitin-proteasome-dependent proteolysis and the partial relief of myogenic differentiation impairment.
In AESOPS-2, a multi-site study, random assignment determines if prescribers to persons who suffer an opioid overdose (fatal or nonfatal) learn of this event (intervention) or practice usual-care (control). The AESOPS-2 trial will take place in 3 diverse health systems in the U.S. - Northwestern Medicine, AltaMed Health Services, and The Children's Clinic. At Northwestern Medicine, clinicians in the intervention group receive a letter notifying them of their patient's fatal or nonfatal ED overdose. At AltaMed Health Services, and The Children's Clinic, clinicians in the intervention group receive a letter notifying them of their patient's nonfatal ED overdose. The primary outcome is the change in clinician weekly milligram morphine equivalent (MME) dose prescribed in 6-month periods before and after receiving the letter. The secondary outcome is the change in the proportion of patients prescribed at least 50 daily MME. Group differences in these outcomes will be compared using an intent-to-treat difference-in-differences framework with a mixed-effects regression model to estimate clinician MME weekly dose. The AESOPS-2 trial will provide new knowledge about whether increasing prescribers' awareness of patients' opioid-related overdoses leads to a reduction in opioid prescribing. Additionally, this trial may better inform how to reduce opioid use disorder and opioid overdoses by lowering unnecessary population exposure to these drugs.
BACKGROUND & AIMS: Activation of hepatic stellate cells (HSCs) is the key process underlying liver fibrosis. Unveiling its molecular mechanism may provide an effective target for inhibiting liver fibrosis. Protein ubiquitination is a dynamic and reversible process. Deubiquitinases (DUBs) catalyze the removal of ubiquitin chains from substrate proteins, thereby inhibiting the biological processes regulated by ubiquitination signals. However, there are few studies revealing the role of deubiquitination in the activation of HSCs.
METHODS & RESULTS: Single-cell RNA sequencing (scRNA-seq) revealed significantly decreased USP18 expression in activated HSCs when compared to quiescent HSCs. In mouse primary HSCs, continuous activation of HSCs led to a gradual decrease in USP18 expression whilst restoration of USP18 expression significantly inhibited HSC activation. Injection of USP18 lentivirus into the portal vein of a CCl4-induced liver fibrosis mouse model confirmed that overexpression of USP18 can significantly reduce the degree of liver fibrosis. In terms of mechanism, we screened some targets of USP18 in mouse primary HSCs and found that USP18 could directly bind to TAK1. Furthermore, we demonstrated that USP18 can inhibit TAK1 activity by interfering with the K63 ubiquitination of TAK1.
CONCLUSIONS: Our study demonstrated that USP18 inhibited HSC activation and alleviated liver fibrosis via modulation of TAK1 activity; this may prove to be an effective target for inhibiting liver fibrosis.
Techniques for promoting assimilation of oligosaccharides such as HMO by enterobacteria, particularly bifidobacteria strains, are provided. As a first aspect, a composition comprising tocopherol for promoting the assimilation of oligosaccharides is provided. As a second aspect, a nutritional composition (excluding breast milk) is provided comprising oligosaccharides and tocopherols. The tocopherol in the aspect comprises one, two or more selected from the group consisting of beta-tocopherol, gamma-tocopherol, and delta-tocopherol. The oligosaccharide in said aspect is preferably human milk oligosaccharide. In the aspect, the mass ratio of the delta-tocopherol content to the beta-tocopherol content (delta/beta) is preferably 5 or more, and the mass ratio of the gamma-tocopherol content to the delta-tocopherol content (gamma/delta) is preferably 8.8 or less.
Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence.
Participants assigned to the adaptive intervention condition will be scheduled for buprenorphine medication management appointments according to the clinic protocol described above for TAU. The adjunctive psychosocial treatment that participants in this condition receive are (1) CBT delivered by behavioral health specialists and/or (2) peer support delivered by certified recovery specialist. The active intervention period will span 3 months post-study entry. Participants will continue to receive TAU following the active intervention period.
Patients receive SIM PO TID on days -5 to -1 and 1-5. Patients undergo standard of care surgery on day 0.
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast. Research on combined use of IVIM and ASL MRI in patients with AKI is rare. This study aims to investigate the MRI characteristics of IVIM and ASL in patients with tubulointerstitial nephritis (TIN) and to explore their relationship with pathological findings and renal recovery.
METHODS AND ANALYSIS: Single-centre, prospective, observational cohort study of 30 patients with biopsy-proven TIN. Participants will undergo renal IVIM and ASL MRI within 7 days post-biopsy. The pathological assessments of active and chronic tubulointerstitial injuries will be semiscored using modified Banff criteria. The estimated glomerular filtration rate (eGFR) during follow-up and prevalence of chronic kidney disease at 3 and 6 months will be reported. An eGFR below 45 mL/min is considered a poor renal outcome.
ETHICS AND DISSEMINATION: The study has been reviewed and approved by the Ethics Committee of Peking University First Hospital and written informed consent will be obtained from all participants (2022Y503). The study results will be disseminated through publication in a relevant peer-reviewed journal and presentation at academic meetings to increase awareness and share findings with the scientific community.
Group B will receive a Muscle Energy Technique (MET) applying the reciprocal inhibition principle. Participant will be in supine lying and the affected muscle held in a mid-range position. The Reciprocal Inhibition-MET group stretched for 10 to 60 seconds after performing an isometric contraction of the muscle opposite the one that needed to be stretched for 7 to 10 seconds (30%-50% of the time) followed by 5 second rest interval. With a pause of 20 seconds in between each repetition, this sequence was performed five times(52). The readings for Active knee Extension (AKE), TUG test and WBFPS before and after treatment session determined the improvement regarding the treatment outcomes.