anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The purpose of this study is to investigate the effect of homotopic and heterotopic sensory afferent input on surround inhibition in the motor cortex. Surround inhibition is a cortical phenomenon, the function of which may be to suppress unwanted movements in surrounding muscles during voluntary actions. In support of this, a recent study showed that motor output to the little finger was reduced during self-paced, voluntary movements of the index finger, despite an increase in spinal excitability. Work has also shown that in relaxed muscle, homotopic and heterotopic peripheral stimulation results in time dependent modulation of motor cortical excitability. However, no studies have examined the relationship between volitional movement and afferent sensory input on cortical surround inhibition. Therefore, the aim of this study is to examine the changes in surround inhibition when electrical stimulation is applied to either the finger being actively moved (homotopic stimulation) or a separate finger not involved in the movement (heterotopic stimulation) at different time periods prior to the initiation of movements to assess the affect of these stimuli on surround inhibition and excitation in the motor cortex.
Provided are a single-stranded oligonucleotide targeting an IGF2BP3 protein and a use thereof. The single-stranded oligonucleotide is obtained by any one of the following codes: 1) a nucleotide sequence as shown in SEQ ID NO. 1; 2) a nucleotide sequence obtained by chemically modifying the nucleotide sequence as shown in SEQ ID NO. 1; 3) a nucleotide sequence that is obtained by substituting, deleting and/or adding one or more nucleotides in the nucleotide sequence as shown in SEQ ID NO. 1 and has the same function; and 4) a nucleotide sequence having 90% or more homology with the nucleotide sequence of 1), 2) or 3) and having the same function. The single-stranded oligonucleotide can block the mRNA binding capability of the IGF2BP3 protein for recognition of the single-stranded oligonucleotide in a targeted manner, and has application value in liver cancer proliferation and metastasis.
In search of potential anticancer agents, we synthesized SNO-donor salicylaldimine main ligand-based Pt(II) complexes bearing NH3 as co-ligand at trans-position (C1-C6). These complexes showed similarity in structure with transplatin as the two N donor atoms of the main ligand and NH3 co-ligand were coordinated to Pt in trans position to each other. Each complex with different substituents on the main ligand was characterized thoroughly by detailed spectroscopic and spectrophotometric methods. Four of these complexes were studied in solid state by single crystal X-ray analysis. The stability of reference complex C1 was measured in solution state in DMSO‑d6 or its mixture with D2O using 1H NMR methods. These complexes were further investigated for their anticancer activity in triple-negative-breast (TNBC) cells including MDA-MB-231, MDA-MB-468 and MDA-MB-436 cells. All these complexes showed satisfactory cytotoxic effect as revealed by the MTT results. Importantly, the highly active complex C4 anticancer effect was compared to the standard chemotherapeutic agents including cisplatin, oxaliplatin and 5-fluorouracil (5-FU). Functionally, C4 suppressed invasion, spheroids formation ability and clonogenic potential of cancer cells. C4 showed synergistic anticancer effect when used in combination with palbociclib, JQ1 and paclitaxel in TNBC cells. Mechanistically, C4 inhibited cyclin-dependent kinase (CDK)4/6 pathway and targeted the expressions of MYC/STAT3/CCND1/CNNE1 axis. Furthermore, C4 suppressed the EMT signaling pathway that suggested a role of C4 in the inhibition of TNBC metastasis. Our findings may pave further in detailed mechanistic study on these complexes as potential chemotherapeutic agents in different types of human cancers.
INTRODUCTION: Macrophage dysfunction is a common feature of inflammatory disorders such as asthma, which is characterized by a strong circadian rhythm.
METHODS AND RESULTS: We monitored the protein expression pattern of the molecular circadian clock in human peripheral blood monocytes from healthy, allergic, and asthmatic donors during a whole day. Monocytes cultured of these donors allowed us to examine circadian protein expression in human monocyte-derived macrophages, M1- and M2- polarized macrophages. In monocytes, particularly from allergic asthmatics, the oscillating expression of circadian proteins CLOCK, BMAL, REV ERBs, and RORs was significantly altered. Similar changes in BMAL1 were observed in polarized macrophages from allergic donors and in tissue-resident macrophages from activated precision cut lung slices. We confirmed clock modulating, anti-inflammatory, and lung-protective properties of the inverse ROR agonist SR1001 by reduced secretion of macrophage inflammatory protein and increase in phagocytosis. Using a house dust mite model, we verified the therapeutic effect of SR1001 in vivo.
DISCUSSION: Overall, our data suggest an interaction between the molecular circadian clock and monocytes/macrophages effector function in inflammatory lung diseases. The use of SR1001 leads to inflammatory resolution in vitro and in vivo and represents a promising clock-based therapeutic approach for chronic pulmonary diseases such as asthma.
At each treatment, subjects had 2 mL (2 mg) of tenecteplase instilled into each lumen of their HD catheter. Subjects could receive up to three treatments with tenecteplase, the first two as part of the initial treatment course and one additional treatment as part of the retreatment (RT) course. The first treatment, followed by a 1-hour dwell time, was given to all subjects at Visit 1. At the end of hemodialysis at Visit 1, eligible subjects had a second treatment instilled for an extended dwell time until the start of Visit 2 (up to 72 hours).
PURPOSE:To enable quick immune reaction under a uniform condition without the need for any laborious operation and with the use of an extremely small amt. of an immune reaction medium by using a styrene polymer incorporated therein with a sulfonic acid group in constituting a solid-phase carrier for immune measurement. CONSTITUTION:A solid-phase carrier made of polystyrene molded to a prescribed shape is subjected to a pretreatment for one hour at 5 deg.C and thereafter it is put into a cooled concd. sulfuric acid and is brought into reaction preferably for 6hr. The solid-phase carrier is removed from said acid after the reaction and is thoroughly washed with distilled water. When the carrier is further thoroughly washed repeatedly with 100mM phosphoric acid buffer soln. (8.0pH), a polystyrene solid-phase carrier 1 incorporated therein with the sulfonic acid group is obtd. The resulting carrier 1 has an extremely large amt. of immobilizing antibody per carrier and therefore a satisfactory immune measurement is made possible with an extremely small amt. of the antibody as well. Since the coupled antibody exists in an extremely stable form, the carrier withstands long-time and frequent use and has a good rate of maintaining the activity of the antibody.
To evaluate the relative effectiveness of 2 theoretically-informed approaches to preventing the adverse sequelae of maltreatment in infants: Psychoeducational Home Visitation (PHV) and Infant-Parent Psychotherapy (IPP). Non-maltreated infants and their mothers serve as a comparison.

Maltreated infants and their mothers are randomly assigned to 1 of 3 types of intervention for 12 months: 1) Services routinely available in the community when a family is reported for child maltreatment (Child Protective Services, CPS); 2) CPS involvement plus weekly PHV; 3) CPS involvement plus weekly IPP. Intervention is provided until the infant's second birthday. All mother-infant dyads (including comparison non-maltreated infants and their mothers) participate in baseline assessments at the infant's age of 12 months. Subsequent assessments occur at 18, 24, 36, and 48 months of age. Assessments measure three major areas: 1) family-ecological variables; 2) maternal functioning and parenting; and 3) child functioning and stage-salient issues. CPS records are monitored annually across all groups to determine whether any reports of maltreatment have been filed.
Decreasing donor chimerism is considered as an early sign of graft failure or relapse in patients undergoing allogeneic stem cell transplantation. The treatment option included tapering or stop of immunosuppression and or donor lymphocyte infusion (DLI) which may restore a full donor chimerism but subsequent GVHD is the major complications. In this single arm prospective study, the investigator plan to evaluate the effect and safety of low-dose decitabine treatment alone in patients with decreased donor chimerism after allo-HSCT. The investigators expect an overall response rate of 80% without serious toxicity such as grade III-IV aGVHD, ext cGVHD and lethal infection event associated with low-dose decitabine (LD-DAC) treatment. In case of donor chimerism decreasing, 5-day low-dose decitabine (5mg/m2) will given every 6 to 8 weeks until full donor chimerism is achieved (\>98%). Fast withdraw of immuno-suppression or stop of immunosupression is not carried out in the study.
The AVP + placebo group will self-administer no more than 1 ml solution of vasopressin or placebo in each nostril; five (5) sprays per each nostril, for a total of ten (10) sprays. The order of administration of drug and placebo will counterbalanced across subjects, such that half will receive AVP first, and half will receive AVP second.
The new type of Coronavirus Disease (COVID-19), which emerged in China in December 2019, has spread rapidly worldwide. It was declared a global pandemic by the World Health Organization on March 11, 2020 (WHO, 2020). COVID-19 poses a significant threat to the entire society. For this, educational institutions that seem to be risky among the measures taken worldwide have been closed (1). For this reason, it has been decided to continue all education activities through distance education from November 20, 2020, until January 4, 2021. Afterward, it was decided to conduct face-to-face education and training activities in certain stages (2,3).

The importance of education and information activities to prevent COVID-19 disease and reduce the spread of the disease is indisputable. Due to the initiation of face-to-face education, informing school-age children about prevention from the epidemic plays a crucial role in making the school environment safe (4). One of the methods that can be used to inform school-age children about COVID-19 is animations created within the scope of play therapy because animations provide psychomotor, cognitive, social, and emotional development of children and give them positive behaviors and habits (5-7). Concordantly, nurses who stay in close and long-term communication with children, as are with all segments of society, have tremendous responsibilities. Providing accessible, accurate, and evidence-based health information about the epidemic is among the accountabilities of nurses (8). Benefiting from theories and models that offer a professional approach to nursing has many benefits, such as increasing the quality of education, guiding practice, and increasing the health level of individuals (9). For this purpose, the health promotion model (10), created by Pender is suitable to be used in nursing studies carried out to protect against COVID-19 disease
Carcinogenicity studies have not been conducted with selinexor. 

Selinexor was not mutagenic in vitro in a bacterial reverse mutation (Ames) assay and was not clastogenic in either the in vitro cytogenetic assay in human lymphocytes or in the in vivo rat micronucleus assay. 

Fertility studies in animals have not been conducted with selinexor. In repeat-dose oral toxicity studies, selinexor was administered for up to 13 weeks in rats and monkeys. Reduced sperm, spermatids, and germ cells in epididymides and testes were observed in rats at ≥1 mg/kg, decreased ovarian follicles were observed in rats at ≥2 mg/kg, and single cell necrosis of testes was observed in monkeys at ≥1.5 mg/kg. These dose levels resulted in systemic exposures approximately 0.11, 0.28, and 0.53 times, respectively, the exposure (AUClast) in humans at the recommended human dose of 80 mg.
One of the major consequences of the COVID-19 pandemic has been the significant incidence of persistent fatigue following resolution of an acute infection (i.e. post-COVID fatigue). We have shown previously that, in comparison to healthy controls, those suffering from post-COVID fatigue exhibit changes in muscle physiology, cortical circuitry, and autonomic function. Whether these changes preceded infection, potentially predisposing people to developing post-COVID fatigue, or whether the changes were a consequence of infection was unclear. Here we present results of a 12-month longitudinal study of 18 participants from the same cohort of post-COVID fatigue sufferers to investigate these correlates of fatigue over time. We report improvements in self-perception of the impact of fatigue via questionnaires, as well as significant improvements in objective measures of peripheral muscle fatigue and autonomic function, bringing them closer to healthy controls. Additionally, we found reductions in muscle twitch tension rise times, becoming faster than controls, suggesting that the improvement in muscle fatigability might be due to a process of adaptation rather than simply a return to baseline function.
An engineered vaccinia virus, pharmaceutical compositions comprising the virus, and methods of using the virus to treat a subject in need thereof are provided. Engineered vaccinia viruses include mutated viral sequences and heterologous sequences. The mutated viral sequences are useful for selective replication in tumor cells and/or activation of immune cells. The heterologous sequence encodes an immune co-stimulatory pathway activating molecule, an immunomodulator gene, a truncated viral envelope gene and/or a tumor suppressor. The heterologous sequence is stably integrated into the genome of the engineered vaccinia virus. The pharmaceutical composition comprises an effective amount of an engineered vaccinia virus and a pharmaceutically acceptable carrier. A method for treating a subject in need thereof comprises administering an engineered vaccinia virus to the subject.
The Vietnam Era Twin (VET) Registry is a closed cohort composed of 7,369 middle-aged male-male twin pairs both of whom served in the military during the time of the Vietnam conflict (1965-1975). The Registry is a United States Department of Veterans Affairs resource that was originally constructed from military records; the Registry has been in existence for more than 15 years. It is one of the largest national twin registries in the US and currently has subjects living in all 50 states. Initially formed to address questions about the long-term health effects of service in Vietnam the Registry has evolved into a resource for genetic epidemiological studies of mental and physical health conditions. Several waves of mail and telephone surveys have collected a wealth of health-related information on Registry twins. Other data collection efforts have focused on specific sets of twin pairs and conducted detailed clinical or laboratory testing.
Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), but its mechanism of onset remains unclear. Since impaired mitophagy has been implicated in multiple organs in SLE, we hypothesized that mitophagy dysfunction is critical in the development of LN and that pharmacologically targeting mitophagy would ameliorate this disease. Therefore, lupus-prone MRL/MpJ-Faslpr (MRL/lpr) and NZBWF1/J mice were treated with a novel mitophagy inducer, UMI-77, during their onset of LN. This treatment effectively mitigated kidney inflammation and damage as assessed by histology and flow cytometry. Furthermore, dendritic cell (DC)-T-cell coculture assay indicated that UMI-77 treatment attenuated DC function that would drive T-cell proliferation but did not directly influence the potent T-cell proliferation in lupus mice. UMI-77 also restored mitochondrial function and attenuated proinflammatory phenotypes in lupus DCs. Adoptive transfer of DCs from MRL/lpr mice augmented serum anti-dsDNA IgG, urine protein and T-cell infiltration of the kidney in MRL/MpJ mice, which could be prevented by either treating lupus donors in vivo or lupus DCs directly with UMI-77. UMI-77 also restored mitochondrial function in myeloid cells from patients with LN in vitro as evidenced by increased ATP levels. Thus, enhancing mitophagy in SLE restrains autoimmunity and limits kidney inflammation for LN development. Hence, our findings suggest targeting mitophagy as a tangible pathway to treat LN.
Patients will be randomized to receive one of three social needs screening instruments. The NCCN Distress thermometer is a single-item tool designed to measure patients' current level of distress. Patients are asked to rate their distress using a 10-point Likert scale, where 0=no distress and 10=extreme distress. The Problem List (PL) helps physicians identify the sources of patients' distress and direct patients to appropriate support services. The NCCN DT+PL is a widely used, validated tool for evaluating distress in patients diagnosed with or receiving treatment for cancer.
Time-restricted feeding (TRF) has emerged as a promising dietary approach for improving metabolic parameters associated with obesity. However, it remains largely unclear whether TRF offers benefits for obesity related to exposure to light at night. This study examined whether lean and obese mice under chronic light exposure could benefit from TRF intervention. Six-week-old C57BL/6 male mice were fed either a low-fat diet or a high-fat diet under a 12 h light/12 h dark cycle for 6 weeks. They were then divided into three subgroups: control light, chronic 24 h light, and chronic light with a daily 10 h TRF. Chronic light exposure led to increased weight gain and higher expression of inflammatory and fibrotic markers in the adipose tissue of both lean and obese mice. It also increased hepatic triglyceride content in mice, regardless of their weight status. TRF protected both lean and obese mice from weight gain, normalized inflammatory and fibrotic gene expression, and reduced adipose tissue collagen and liver triglyceride accumulation caused by light exposure alone or in combination with obesity. These results suggest that TRF could have clinical implications for preventing obesity associated with night shift work, regardless of current weight status.
OBJECTIVE: To investigate the impact of the precise dissection and reconstruction of the prostate apex and bladder neck urethra during radical prostatectomy on the improvement in postoperative urinary control in patients with prostate cancer.
METHODS: A retrospective study was conducted. A total of 131 prostate cancer patients who underwent robot-assisted radical prostatectomy at our institution between January 1, 2023 and December 31, 2023 were enrolled. The subjects were divided into two groups, with 64 in the experimental group and 67 in the control group. Patients in the experimental group underwent radical prostatectomy in a modified approach, while those in the control group underwent conventional radical prostatectomy. Propensity score matching was employed to match the two groups at a 1-to-1 ratio based on age, body mass index (BMI), preoperative prostate specific antigen (PSA), prostate volume, Prostate Imaging Reporting and Data System (PI-RADS) scores, biopsy Gleason score, and preoperative urinary control status. After matching, we compared the preoperative baseline data, surgical margin positivity rates, and urinary control status at 3 months post operation between the two groups. Urinary control was assessed before and after surgery using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) scale.
RESULTS: A total of 56 pairs of patients were successfully matched between the experimental group and the control group through 1-to-1 propensity score matching. At 3 months after surgery, the median score for ICIQ-SF scale of the experimental group was 7.0 points, while that of the control group was 9.5 points, with the difference being statistical significant (P<0.05). There was no significant difference in the positive rate of incision margins between the experimental group and the control group. Multiple linear regression analysis showed that both the prostate volume and the Gleason score in the experimental group were positively correlated with the ICIQ-UI SF scores 3 months after surgery (P<0.05), while the age of patients in the control group was positively correlated with ICIQ-UI SF score 3 months after surgery (P<0.05).
CONCLUSION: Precise dissection and reconstruction of the prostate apex and bladder neck urethra during radical prostatectomy significantly improve the postoperative urinary control of patients at 3 months after surgery.
PURPOSE: Provided is a shampoo product for prevention of depilation using ray flower, Acorus calamus var. angustatus, green tea and aloe as active ingredients. It helps metabolism of the hair and prevents scalp from oxidation. CONSTITUTION: A shampoo product for the prevention of depilation is characterized by containing the extract of ray flower, Acorus calamus var. angustatus, green tea and aloe as an active ingredient. The extraction solvent includes ethanol and purified water.
Epidural fluid collection is commonly seen as a low-density accumulation beneath the dura on postoperative computed tomography scans. It is discussed less in the literature because, in most cases, the fluid amount is small, self-absorbing, and typically does not cause neurological deficits, so intervention is usually unnecessary. However, when a significant amount of fluid accumulates, patients may experience symptoms such as altered consciousness and even coma. In such cases, treatment is necessary to reduce intracranial pressure, preventing further deterioration of consciousness and potentially life-threatening situations. The authors report a case of a large epidural fluid collection following cranioplasty, resulting in progressive deterioration of consciousness in the patient. Computed tomography scans indicated brain herniation. Subsequently, percutaneous puncture and suction treatment were performed, followed by appropriate pressure dressing. The patient gradually recovered from a shallow coma to clear consciousness and was discharged after rehabilitation.