anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns a pharmaceutical industry, in particular to compositions for treatment of adiposity and resistance to insulin at regulation of levels of glucose in blood. A way of treatment of adiposity and resistance to insulin at regulation of levels of a glucose in the blood, including introduction of therapeutically effective quantity of the composition containing bond, chosen from the group, including an anthocyanin, anthocyanidin and their admixtures, for resistance treatment to insulin at regulation of levels of a glucose and treatment of adiposity at the patient. Way of treatment of adiposity at the people, suffering diabetes, adiposity and resistance to insulin at regulation of levels of a glucose in blood and accepting a medicinal preparation for treatment of diabetes which includes introduction of therapeutically effective quantity of the composition containing bond, chosen from the group, including an anthocyanin, anthocyanidin and their admixtures in a combination to an accepted medicinal preparation for regulation of levels of a glucose and treatment of the people, suffering diabetes. A way of treatment of adiposity and resistance to insulin at regulation of levels of a glucose in blood and the hyperglycaemia treatments, including introduction of therapeutically effective quantity of the composition containing bond, chosen from the group, including an anthocyanin, anthocyanidin and their admixtures, for treatment of adiposity, resistance to insulin and a hyperglycaemia. Way of treatment of adiposity, resistance to insulin at regulation of levels of a glucose in blood and the lipide disturbances, including introduction of therapeutically effective quantity of the composition containing bond, representing an anthocyanin, anthocyanidin or their admixtures, for treatment of adiposity, resistance to insulin and lipide disturbances. Way of treatment of adiposity, resistance to insulin at regulation of levels of a glucose in blood and a hypercholesterinemia, including introduction of therapeutically effective quantity of the composition containing bond, representing an anthocyanin, anthocyanidin or their admixtures, for treatment of adiposity, resistance to insulin at regulation of levels of a glucose in blood, a hypercholesteremia. A way of treatment of adiposity, resistance to insulin at regulation of levels of a glucose in blood and an atherosclerosis including introduction of therapeutically effective quantity of the composition containing bond, chosen from the group, including an anthocyanin, anthocyanidin or their admixtures, for treatment of adiposity, resistance to insulin at regulation of levels of a glucose in blood and an atherosclerosis. The above described ways of treatment of adiposity, resistance to insulin at regulation of levels of glucose in blood, lipide disturbances, a hypercholesterinemia, an atherosclerosis are effective. ^ EFFECT: working out of an effective way of treatment of adiposity and resistance to insulin. ^ 16 cl, 9 dwg
The present invention discloses an ovine enoxaparin sodium, a preparation method therefor, and an application thereof. The ovine enoxaparin sodium is prepared from ovine heparin. Compared with enoxaparin sodium derived from porcine intestinal mucosa heparin, both the chemical structures (disaccharide compositions) and the physiochemical properties are different. Through process of optimization and precipitation, the ovine enoxaparin sodium prepared meets the enoxaparin sodium specifications in the USP 37 and the EP 8.0 as well as specifications in current editions of the USP 39 and the EP 8.6. Also provided are two types of ovine enoxaparin sodium injections, preparation methods therefor, and anticoagulation properties in animal model. The raw material used in the preparation is ovine, which is a Halal material compared to porcine enoxaparin sodium. Therefore, the ovine enoxaparin sodium and the injections thereof are an Halal anticoagulant medicine.
Imatinib Mesylate, given daily orally, 55 mg PO BID, if tolerated for 2 weeks increase to 110 mg/m2 BID, and further increase to 165 and final dosage to 220 mg/m2 bid if tolerated. Can continue for 12 months.
FIELD: polymeric hydrogels, chemistry of polymers, medicine, biochemistry. SUBSTANCE: method involves preparing insulin-containing polymeric hydrogels by insulin immobilization in the volume of cross-linked polymer modified with proteolytic enzyme inhibitor - ovomucoid. Ovomucoid concentration in cross-linked polymer is 0.2-25 mg/g hydrogel swelled in water. These insulin-containing hydrogels can be used as medicinal preparation for treatment of patients with diabetes mellitus. EFFECT: improved method of hydrogel preparing. 2 cl
For four weeks: Fasting for 16 hours from participant last meal of the previous evening's meal to the first meal of the next day. Then for 8 hours, participant is able to eat. During the fasting, participants are allowed to consume water and black coffee/tea. Participants will also keep their normal weekly exercise routine.
Ovarian cancer is a cancer that forms in or on an ovary. The majority of ovarian cancers arise from the epithelium (outer lining) of the ovary. In 2015 it was reported found in 1.2 million women and resulted in 161,100 deaths worldwide. Among women it is the seventh-most common cancer and the eighth-most common cause of death from cancer. Treatment for ovarian cancer consists of surgery, chemotherapy, immunotherapy and sometimes, radiotherapy. The kind of treatment depends on many factors, including the type of ovarian cancer, its stage and grade, as well as the general health of the patient.

Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) reactive with specific viral antigens has proven to be effective. Here, the investigators aim to evaluate the safety and efficacy of multiple infusions of ovarian cancer specific cytotoxic T lymphocytes in patients.
The safety and effectiveness of doxercalciferol capsules were evaluated in two clinical studies in 55 patients with Stage 3 or 4 CKD. Eighty-two percent of the patients were male, the average age was 65 years, 51% were Caucasian, 40% African-American, and the average serum intact PTH level at baseline was 195 pg/mL. While levels of 25-(OH) vitamin D were not evaluated at baseline, retrospective assessments of stored serum revealed that the mean ± SD serum 25-(OH) vitamin D was 19 ± 8 ng/mL (range: <5 to 54 ng/mL) in the study population. 

After randomization to two groups, eligible patients underwent an 8-week washout period during which no vitamin D derivatives were administered to either group. Subsequently, one group received doxercalciferol capsules and the other placebo during the double-blind period of 24 weeks. The initial dose of doxercalciferol capsules was 1 mcg per day. The dosage of doxercalciferol capsules was adjusted as necessary by the investigator to reduce intact PTH levels to a target of ≥30% below postwashout baseline. The maximum dosage was limited to 3.5 mcg per day. If at any time during the trial intact PTH fell below 15 pg/mL, doxercalciferol capsules were immediately suspended and restarted at a lower dosage the following week. 

Decreases in the mean plasma intact PTH from baseline values were calculated using as baseline the average of the last 2 values obtained during the 8-week washout phase. In analyses of pooled data from the two studies, intact PTH levels decreased from baseline by an average of 101 pg/mL in the doxercalciferol capsules group and by 4 pg/mL in the placebo group (p<0.001). Twenty (74%) of 27 subjects in the doxercalciferol capsules group achieved mean plasma intact PTH suppression of ≥30% from baseline for the last four weeks of treatment, whereas two (7%) of the 28 subjects treated with placebo achieved this level of intact PTH suppression.
BACKGROUND: This study evaluated the clinical relevance of a set of five serum-derived circulating microRNAs (miRNAs) in colorectal cancer (CRC). Additionally, we investigated the role of miR-20a-5p released by exosomes derived from cancer-associated fibroblasts (CAFs) in the context of CRC.
METHODS: The expression levels of five circulating serum-derived miRNAs (miR-20a-5p, miR-122-5p, miR-139-3p, miR-143-5p, and miR-193a-5p) were quantified by real-time quantitative PCR (RT-qPCR), and their associations with clinicopathological characteristics in CRC patients were assessed. The diagnostic accuracy of these miRNAs was determined through Receiver Operating Characteristic (ROC) curve analysis. CAFs and normal fibroblasts (NFs) were isolated from tissue samples, and subsequently, exosomes derived from these cells were isolated and meticulously characterized using electron microscopy and Western blotting. The cellular internalization of fluorescent-labeled exosomes was visualized by confocal microscopy. Gain- and loss-of-function experiments were conducted to elucidate the oncogenic role of miR-20a-5p transferred by exosomes derived from CAFs in CRC progression. The underlying mechanisms were uncovered through luciferase reporter assay, Western blotting, enzyme-linked immunosorbent assays, as well as proliferation and migration assays.
RESULTS: The expression levels of serum-derived circulating miR-20a-5p and miR-122-5p were significantly higher in CRC and were positively correlated with advanced stages of tumorigenesis and lymph node metastasis (LNM). In contrast, circulating miR-139-3p, miR-143-5p, and miR-193a-5p were down-regulated in CRC and associated with early tumorigenesis. Except for miR-139-3p, they showed a negative correlation with LNM status. Among the candidate miRNAs, significantly elevated levels of miR-20a-5p were observed in both cellular and exosomal fractions of CAFs. Our findings indicated that miR-20a-5p induces the expression of EMT markers, partly by targeting PTEN. Exosomal miR-20a secreted by CAFs emerged as a key factor enhancing the proliferation and migration of CRC cells. The inhibition of miR-20a impaired the proliferative and migratory potential of CAF-derived exosomes in SW480 CRC cells, suggesting that the oncogenic effects of CAF-derived exosomes are mediated through the exosomal transfer of miR-20a. Furthermore, exosomes originating from CAFs induced increased nuclear translocation of the NF-kB p65 transcription factor in SW480 CRC cells, leading to increased interleukin-6 (IL-6) production.
CONCLUSIONS: We established a set of five circulating miRNAs as a non-invasive biomarker for CRC diagnosis. Additionally, our findings shed light on the intricate mechanisms underpinning the oncogenic impacts of CAF-derived exosomes and underscore the pivotal role of miR-20a-5p in CRC progression.
BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare neoplastic and cystic pulmonary disease characterized by abnormal proliferation of the so-called LAM cells. Despite the functional obstructive pattern observed in most patients, few studies investigated the morphological changes in the small airways, most of them in patients with severe and advanced LAM undergoing lung transplantation. Understanding the morphological changes in the airways that may occur early in the disease can help us understand the pathophysiology of disease progression and understand the rationale for possible therapeutic approaches, such as the use of bronchodilators. Our study aimed to characterize the morphological alterations of the small airways in patients with LAM with different severities compared to controls, and their association with variables at the pulmonary function test and with LAM Histological Score (LHS).
METHODS: Thirty-nine women with LAM who had undergone open lung biopsy or lung transplantation, and nine controls were evaluated. The histological severity of the disease was assessed as LHS, based on the percentage of tissue involvement by cysts and infiltration by LAM cells. The following morphometric parameters were obtained: airway thickness, airway closure index, collagen and airway smooth muscle content, airway epithelial TGF-β expression, and infiltration of LAM cells and inflammatory cells within the small airway walls.
RESULTS: The age of patients with LAM was 39 ± 8 years, with FEV1 and DLCO of 62 ± 30% predicted and 62 ± 32% predicted, respectively. Patients with LAM had increased small airway closure index, collagen and smooth muscle content, and epithelial TGF-beta expression compared with controls. Patients with LAM with the more severe LHS and with greater functional severity (FEV1 ≤ 30%) presented higher thicknesses of the airways. Bronchiolar inflammation was mild; infiltration of the small airway walls by LAM cells was rare. LHS was associated with an obstructive pattern, air trapping, and reduced DLCO, whereas small airway wall thickness was associated with FEV1, FVC, and collagen content.
CONCLUSION: LAM is associated with small airway remodelling and partial airway closure, with structural alterations observed at different airway compartments. Functional impairment in LAM is associated with airway remodelling and, most importantly, with histological severity (LHS).
These are patients who were diagnosed with COVID19 and recovered with usual care prior to implementation of the rehabilitation program developed by MUHC therapists. These patients will be selected in such a way as to match the approximate demographics that exist within the treatment group. These patients received education and supportive care only.
INTRODUCTION: Nonalcoholic fatty liver disease is the leading cause of pediatric chronic liver disease. Although nonalcoholic fatty liver disease is closely associated with obesity, its relationship with metabolic syndrome in children is not fully understood. The main aim of this study was to evaluate the association between nonalcoholic fatty liver disease and a combination of cardiometabolic risk factors in adolescents with overweight/obesity, using a pediatric metabolic syndrome score (PsiMS) to predict metabolic syndrome.
METHODS: A retrospective cohort study was conducted. Subjects with overweight/obesity aged 10 to 17 followed at two clinical centers in Portugal (2018 - 2021) were enrolled. The independent association of nonalcoholic fatty liver disease with PsiMS, and of other potential predictors, was tested through multiple regression analyses. Receiver operator characteristic curve analysis was performed to estimate the optimal cutoff of PsiMS to discriminate metabolic syndrome.
RESULTS: Eighty-four subjects were included (median age at baseline 11.5 years). The prevalence rate of nonalcoholic fatty liver disease was 51% and the prevalence rate of metabolic syndrome was 7%. The mean PsiMS was 2.05 ± 0.48 at the first evaluation, and 2.11 ± 0.52 at the last evaluation (mean follow-up time was 15 months). The nonalcoholic fatty liver disease group had significantly (p < 0.05) higher weight and body mass index z-scores, higher rate of severe obesity and higher waist circumference percentile. PsiMS was highly accurate in predicting metabolic syndrome (area under the curve = 0.96), with an optimal cutoff of 2.46 (sensitivity 100%, specificity 89%). In the univariate analysis, no statistically significant association was observed between nonalcoholic fatty liver disease and PsiMS. In the multiple regression analysis, female sex had a negative association with PsiMS (first and last evaluation). Independent predictors of a higher PsiMS at first evaluation were: ≥ 2 metabolic syndrome criteria, body mass index z-score, insulin resistance and dyslipidemia. At the last evaluation, independent predictors of a higher PsiMS were: nonalcoholic fatty liver disease, baseline PsiMS and body mass index increase from baseline.
CONCLUSION: The results suggest a good performance of the PsiMS to assess metabolic syndrome and that nonalcoholic fatty liver disease is associated with PsiMS at follow-up.
Neonates will be placed in an incubator or a cot, depending on their gestational age, and will be supported on side position by nest-shaped rolls according to department's normal practice. The platform on which the mother's heartbeat will be played will be placed under mattress of the incubator or crib. The playing of the mother's recorded heartbeats will be started thirty minutes prior the heel lance and will be continued during and fifteen minutes after the blood sampling. In addition, the neonates will be given a 30% oral glucose solution two minutes prior the heel lance.
503,633. Preparations of medicinal plants. MADAUS, G., MADAUS, F., and MADAUS, H., (trading as MADAUS & CO., DR.). Nov. 6, 1937, No. 30499. Convention date, Dec. 19, 1936. [Class 81 (i)] Preparations of medicinal plants are obtained by finely triturating fresh plants or parts thereof with an insoluble inorganic adsorbent and gradually drying the product in a current of cool air, substances of alkaline reaction being added prior to drying and preferably prior to the trituration. Volatile oils and other constituents present in the plants are retained in the dry products. Adsorbents referred to are colloidal silica, loam, kaolin, fuller's earth, aluminium hydroxide. Alkaline substances referred to are carbonates, bicarbonates and hydroxides of alkali metals or alkaline earths, and alkaline buffer salts or mixtures thereof, particularly such salts as contain the same acid constituents as those naturally present in the plants. Amorphous carbohydrates or carbohydrate derivatives, such as pectin, swollen starch, tragacanth, amyloses and dextrin may also be added. Examples relate : (1) to treatment of thuja with clay and sodium bicarbonate; (2) to treatment of sabina with loam, sodium bicarbonate and pectin; and (3) to treatment of cortex salicis with loess and disodium phosphate. The products are dried to a 2 per cent moisture content by means of a.current of air at a temperature not exceeding 30‹ C. Specification 485,188 is referred to.
<P>PROBLEM TO BE SOLVED: To obtain a new compound having actions for inhibiting tublin polymerization and cell cycles, having antitumor activity against cancer cells acquired multiple drug resistance (MDR) and provide new medicinal agents containing the new compound.  <P>SOLUTION: The new compound is a sulfonamide derivative having a tetrahydroquinoline skeleton and is expressed by general formula (1). A medicinal composition contains the sulfonamide derivative having the tetrahydroquinoline skeleton or its salt as an effective ingredient. A tublin polymerization inhibitor or a cell cycle inhibitor contains the sulfonamide derivative having the tetrahydroquinoline skeleton or its salt as an effective ingredient. An antitumor agent contains the sulfonamide derivative having the tetrahydroquinoline skeleton or its salt as an effective ingredient.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patients with both significant Lower Urinary Tract Dysfunction history suggestive of constipation were treated with lactitol monohydrate syrup 10 g for eight weeks. Following eight weeks of treatment, patients were re-evaluated and those with 50% of symptom improvement were assumed to have a significant improvement attributable to the development of Lower Urinary Tract Dysfunction- Fecal Impaction (LUTD-FI).
This disclosure provides a system for obtaining expression libraries from primate pluripotent stem (pPS) cells. pPS cells can be maintained in vitro without requiring a layer of feeder cells to inhibit differentiation. The role of the feeder cells is replaced by several other culture conditions provided in a suitable combination. Conditions that promote pPS cell growth without differentiation include supporting the culture on an extracellular matrix, and culturing the cells in a medium conditioned by another cell type. The cDNA libraries from such cultures are devoid of transcripts of feeder cell origin, relatively uncontaminated by transcripts from differentiated cells, and can have a high proportion of full-length transcripts. Subtraction libraries can also be produced that are enriched for transcripts modulated during differentiation.
PROBLEM TO BE SOLVED: To obtain the subject agent having an elastase inhibiting activity, keeping the skin taut and elasticity of, holding a state of a young skin and useful for e.g. foundation cosmetics, makeup cosmetics, hair cosmetics or bath liquids, by including a solvent extract of Syzygium aromaticum Merrill et Perry belonging to the family Myrtaceae as an active agent. SOLUTION: This antiaging agent comprising a solvent extract of Syzygium aromaticum Merrill et Perry belonging to the family Myrtaceae is obtained by subjecting an extract from the buds of the above plant to soaking or heat reflux process together with the extract solvent (e.g. methanol, ethanol or 1,3- buthylene glycol), and subjecting it to filtration and concentration. The blending ratio of the extract to the whole agent for external use is 0.001 to 10.0 wt.% based on the dried extract. It is possible to blend e.g. a beautifully whitening agent, moisture-retaining agent, antioxidant or oil component with the antiaging agent. There may be blended e.g. disodium edetate or sodium citrate. The antiaging agent is pref. applied to cosmetics, as an agent type of e.g. an aqueous solution system, solubilization system or emulsion system.
Group B received 8 weeks of waitlist control (minimal treatment - calendar only) , followed by access to the full "Time for Living \& Caring" (TLC) intervention for an additional 8 weeks (calendar + coaching + resources). The TLC intervention turned off after 16 weeks of exposure for all participants.
BACKGROUND: The aim of this study was to investigate the impact of Porphyromonas gingivalis (P. gingivalis) on the progression of oral squamous cell carcinoma (OSCC) through neutrophil extracellular traps (NETs) in the tumor immune microenvironment.
METHODS: The expression of NETs-related markers was identified through immunohistochemistry, immunofluorescence, and Western blotting in different clinical stages of OSCC samples. The relationship between NETs-related markers and clinicopathological characteristics in 180 samples was analyzed using immunohistochemistry data. Furthermore, the ability to predict the prognosis of OSCC patients was determined by ROC curve analysis and survival analysis. The effect of P. gingivalis on the release of NETs was identified through immunofluorescence and immunohistochemistry, both in vitro and in vivo. CAL27 and SCC25 cell lines were subjected to NETs stimulation to elucidate the influence of NETs on various cellular processes, including cell proliferation, migration, invasion, and metastasis in vitro. Furthermore, the impact of NETs on the growth and metastatic potential of OSCC was assessed using in vivo models involving tumor-bearing mice and tumor metastasis mouse models.
RESULTS: Immunochemistry analysis revealed a significant correlation between the NETs-related markers and clinical stage, living status as well as TN stage. P. gingivalis has demonstrated its ability to effectively induce the release of NETs both in vivo and in vitro. NETs have the potential to facilitate cell migration, invasion, and colony formation. Moreover, in vivo experiments have demonstrated that NETs play a pivotal role in promoting tumor metastasis.
CONCLUSION: High expression of NETs-related markers demonstrates a strong correlation with the progression of OSCC. Inhibition of the NETs release process stimulated by P. gingivalis and targeted NETs could potentially open up a novel avenue in the field of immunotherapy for patients afflicted with OSCC.