anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Anorexia, depression, and vomiting are the common adverse effects of chemotherapy in humans and animals. Mirtazapine is primarily used as an appetite stimulant and antiemetic in dogs and cats. Therefore, we evaluated the efficacy of mirtazapine in reducing the gastrointestinal adverse effects in cats receiving doxorubicin chemotherapy. This single-masked, placebo-controlled crossover study enrolled 11 cats with malignant mammary gland tumors. The cats were randomly assigned to receive either mirtazapine (1.88 mg/cat) or placebo every 48 h for 2 weeks from the first initiation of doxorubicin chemotherapy. Each cat was then crossed over to the alternate group on the subsequent chemotherapy with a 1-week wash-out period. The owners were asked to record appetite score, activity score, episodes of vomiting and diarrhea for 2 weeks after each doxorubicin administration. Cats treated with mirtazapine showed significantly increased bodyweight compared with those on placebo (P = 0.010). The appetite and activity scores during mirtazapine treatment was significantly higher than those during placebo treatment (P = 0.005 and 0.018, respectively). Furthermore, the prevalence of episodes of vomiting during mirtazapine treatment was significantly lower than that during placebo treatment (P = 0.026). Our results demonstrate that mirtazapine can significantly increase bodyweight, appetite, and activity and reduce vomiting in cats after doxorubicin chemotherapy.
In this group, the activation of MB (Merck KgaA) was performed using a polymer EDDY tip (VDW, Munich, Germany) with a 25.04 tip diameter and the Sonicmax sonic device (Maximum Dental Inc., Secaucus, NJ, USA) with one activation cycle. The EDDY (VDW) tip was placed in the canal 1 mm short of the working length and moved in a corono-apical direction at a frequency of 6 kHz and an amplitude of 5 mm for 1 minute to achieve MB activation. The MB (Merck KgaA) solution was renewed during the treatment.
INTRODUCTION: Neck pain is a leading cause of disability worldwide. Visceral referred pain is a common form of disease-induced pain, with visceral nociception being referred to somatic tissues.
OBJECTIVE: The aim of this case report was to evaluate the immediate and long term effects of a novel osteopathic visceral technique (OVT) on pain and cervical range of motion (CROM) in a patient with nonspecific neck pain (NS-NP).
METHOD: A case of a 47-year-old female suffering with NS-NP for four months. The patient had sought physiotherapy treatment several times, and occasionally used anti-inflammatory medication to relieve symptoms. The patient presented muscle cervical tenderness and hyperalgesia over the spinous processes of C3-C4 spinal segments with limited CROM. A novel osteopathic visceral manipulation (OVM) technique was applied in the epigastric region targeting the pancreas. Immediately after the treatment, the patient reported reduction in pain evaluated with the numerical evaluation scale (NRS), and a clinically significant increase in pressure pain threshold (PPT) in C3 spinous process. Improvement in CROM was also observed. The post-treatment improvements have been maintained at 1-month of follow-up assessment.
CONCLUSION: A single OVT was effective in reducing cervical pain and increasing CROM in a patient with NS-NP caused by a viscerosomatic reflex. The results of this case study provides preliminary evidence that OVM can produce hypoalgesia in somatic tissues with segmentally related innervation. This finding encourages future research to gain a better understanding of the mechanisms of regional inhibitory interdependence involving the viscerosomatic reflexes of OVM.
PURPOSE: High altitude retinopathy (HAR) is a retinal functional disorder caused by inadequate adaptation after exposure to high altitude. However, the cellular and molecular mechanisms underlying retinal dysfunction remain elusive. Retinal ganglion cell (RGC) injury is the most important pathological basis for most retinal and optic nerve diseases. Studies focusing on RGC injury after high-altitude exposure (HAE) are scanty. Therefore, the present study sought to explore both functional and morphological alterations of RGCs after HAE.
METHODS: A mouse model of acute hypobaric hypoxia was established by mimicking the conditions of a high altitude of 5000 m. After HAE for 2, 4, 6, 10, 24, and 72 hours, the functional and morphological alterations of RGCs were assessed using retinal hematoxylin and eosin (H&E) sections, retinal whole mounts, transmission electron microscopy (TEM), and the photopic negative response (PhNR) of the electroretinogram.
RESULTS: Compared with the control group, the thickness of the ganglion cell layer and retinal nerve fiber layer increased significantly, RGC loss remained significant, and the amplitudes of a-wave, b-wave, and PhNR were significantly reduced after HAE. In addition, RGCs and their axons exhibited an abnormal ultrastructure after HAE, including nuclear membrane abnormalities, uneven distribution of chromatin in the nucleus, decreased cytoplasmic electron density, widening and vacuolization of the gap between axons, loosening and disorder of myelin sheath structure, widening of the gap between myelin sheath and axon membrane, decreased axoplasmic density, unclear microtubule and nerve fiber structure, and abnormal mitochondrial structure (mostly swollen, with widened membrane gaps and reduced cristae and vacuolization).
CONCLUSIONS: The study findings confirm that the morphology and function of RGCs are damaged after HAE. These findings lay the foundation for further study of the specific molecular mechanisms of HAR and promote the effective prevention.
Topical analgesic compositions comprise a hydrophilic carrier; at least one of mono-, di- or triethylamine salicylate and N-alkyl substituted salicylamides; at least one aminoalkyl ester of benzoic acid or alkyl ester of amino-benzoic acid; and at least one chlorinated phenolic compound.  Specified benzoic acid derivatives are ethyl-p-aminobenzoate (benzocaine), butyl aminobenzoate and piperocaine hydrochloride; specified phenolic compounds are hexochlorophene, p-chlorophenol and chlorothymol. The compositions may be in such forms as creams, ointments, salves and sprayable compositions, i.e. solutions, e.g. in isopropanol in pressurized containers under argon or other chemically inert gases, e.g. CO2, which forms may optionally also comprise additives such as coolants, surfactants, fungicides and protective colloids.
PROBLEM TO BE SOLVED: To provide an artificial dental root which is easily producible and has good bioaffinity and high strength. SOLUTION: This artificial dental root 1 comprises an implanted part 3 to be implanted into a bone tissues and a crown fixing part 2 to be fixed with the tooth crown. The implanted part 3 and the crown fixing part 2 are respectively composed of metallic materials consisting of Ti as a basic component and contg. 0.01 to 3wt.% M (where M is at least one kind among Ca, P and Si). Coating layers 6 are formed on the outside surfaces of these metallic materials. The metallic materials constituting the implanted part 3 and the crown fixing part 2 are respectively produced by a metallic powder injection molding method.
An image of a garment is obtained (101). The garment comprises a marker located on an outside surface of the garment. The marker comprises a code string identifying the garment encoded into a visual symbol. The image is processed to generate a data string representing the visual symbol (102). The data string is used to access activity data associated with a sensor of the garment identified by the code string. The system comprises the garment and one or more electronic devices operable to perform the method.
PURPOSE: A cosmetic composition containing Ricinus communis L. extract and Sophora japonica flower extract is provided to effectively remove cellulite and to ensure body slimming. CONSTITUTION: A cosmetic composition which prevents and treats cellulite contains Ricinus communis L. extract and Sophora japonica flower extract as an active ingredient. The cosmetic composition also contains Zanthoxylum piperitum, Biota orientalis extract, Rugosa rose extract, Foxglove extract, Anemarrhena asphodeloides, Polygonum extract or Lygodii Spora extract. The cosmetic composition contains high isoquercitrin content. The extracts are prepared by hot water extraction or by low carbon number alcohols. A cosmetic composition which removes cellulite contains isoquercitrin, derivatives thereof, or salts thereof. [Reference numerals] (AA) Relative reporter activity
Background and Objectives: In socket preservation, the goal is to minimize bone resorption after tooth extraction to maintain the volume and contour of the alveolar ridge. The use of PRF in post extraction sites may reduce ridge resorption by encouraging the growth of new bone and acting as a scaffold for tissue. In addition, PRF may enhance healing and minimize postoperative pain. The aim of this study was to evaluate the effectiveness of platelet-rich fibrin (PRF) in maintaining the ridges' dimensions at the extraction site, in the maxilla and mandible, as well as its impact on post-extraction discomfort. Methods: The study was conducted on 60 patients presenting for extraction of posterior teeth and was randomly divided into three groups: group I PRF (n = 20), group II PRF + collagen (n = 20), and group III control (n = 20). Sockets were filled with PRF (group I) and PRF + collagen (group II). At baseline and follow-up after 3 months, CBCT was used to assess the bone dimensions. The postoperative pain evaluations were performed at 24 h, 3 days, and 7 days after the tooth extraction. The pain rate was evaluated using a numerical rating scale from the British Pain Society. Results: The study examined the effects of platelet-rich fibrin (PRF) and PRF combined with collagen on the height and width of the ridges, as well as the pain experienced by the patients following alveolar ridge preservation surgery. ANOVA and t-tests were used to evaluate and compare the ridge dimensions. Comparing the results to the control group, there were no significant differences in the height or width of the ridges. However, both the PRF and PRF + Collaplug® treatments effectively reduced the short-term postoperative pain. Conclusions: The study findings suggest that platelet-rich fibrin (PRF) and PRF combined with collagen do not exert significant effects on ridge width and height compared to the standard treatment following alveolar ridge preservation. However, it is noteworthy that both the PRF and PRF + collagen treatments demonstrated efficacy in reducing postoperative pain in the short term, offering a potential advantage over standard treatment protocols.
Peripherally inserted central catheters (PICCs) and Central Venous Catheter (CVC) are widely used to deliver fluids directly to the central venous system and can remain in place for as short as a few days to as long as months. One of the highest risks in the use of these catheters is infection, both local and systemic. Currently, these catheters are secured by either sutures or adhesive patches. Sutures can create additional potential entry points for bacteria whereas both sutures and adhesive securement patches hold the catheter hub to the skin resulting in increased difficulty cleaning around the catheter entry site. Furthermore, securing a catheter outside the skin away from the catheter entry point, as with sutures or adhesive securement patches may potentiate pistoning of the catheter which is also believed to possibly increase infection risks. A second risk of intravenous catheter use is dislodgement during normal use and site maintenance. These catheters are often manipulated multiple times a day for blood sampling or injection of fluids. During manipulation, the catheter can be dislodged thus requiring an unplanned replacement of the catheter.

Interrad Medical has developed a means to secure indwelling catheters using a small subcutaneous anchor. With this system, cleaning around the catheter entry site is made easier and can be more thorough. The system is also designed to minimize the risk of catheter dislodgement because once the anchor is deployed, the catheter remains secured. This may simplify dressing changes compared to adhesive devices such as Statlock, which requires the catheter be released from the device and therefore be unsecured during dressing changes.

The objective of this post-market study is to monitor the safety and performance of the SecurAcath when used to secure the catheter to the insertion site via a subcutaneous anchor. The data collected may provide insight for future enhancements to improve the safety and utility of the device. It also provides a means for an early warning of any identified safety issues, and allows physicians to share their experiences thereby improve the quality of care provided to the patients.
Leflunomide is metabolized to one primary (M1) and many minor metabolites. Of these minor metabolites, only 4-trifluoromethylaniline (TFMA) is quantifiable, occurring at low levels in the plasma of some patients. The parent compound is rarely detectable in plasma. At the present time the specific site of leflunomide metabolism is unknown. In vivo and in vitro studies suggest a role for both the GI wall and the liver in drug metabolism. No specific enzyme has been identified as the primary route of metabolism for leflunomide; however, hepatic cytosolic and microsomal cellular fractions have been identified as sites of drug metabolism.
PURPOSE:The titled tea comprising leaves or stems of ginseng as an essential component. CONSTITUTION:Leaves and/or stems of ginseng (e.g., Panax ginseng C.A.Mayer, Panax japonicus C.A.Myer, Panax quinquefol ium Linne, etc.) are collected, thinly cut, washed, boiled or steamed (to make raw material soft and to deactivate oxidase) and/or roasted. In the roasting process, the ginseng is preheated at 150-400 deg.C in a container and roasted in the container for the required time (<=several minutes at 300 deg.C of <=1hr at about 200 deg.C). Then, rubbing is carried out at 10-60min without heating. Furthermore, the ginseng is dried in the sun for a week or dried at 40-90 deg.C by hot-air drying to give ginseng tea. The ginseng tea may be further blended with a component such as ginseng powder, Gynostemma pentaphyllum Makino, oolong tea, adlay tea, etc. EFFECT:A saponin component is effectively extracted and the tea is administered while preventing a particular drug smell and astringency.
The invention discloses a traditional Chinese medicine composition for treating vertigo, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-15 parts of chrysanthemum, 20-30 parts of oyster, 15-25 parts of radix astragali, 6-10 parts of ligusticum wallichii, 4-6 parts of salvia miltiorrhiza, 6-12 parts of rhizoma gastrodiae, 10-20 parts of semen cassiae, and 10-20 parts of tuber fleeceflower stem. Production and taking methods are provided; the production method comprises the steps: putting the raw materials into a drug decocting pot, adding water to cover the raw material medicines, boiling with big fire, then decocting for 30-60 minutes with small fire, pouring out a medicinal liquid, then adding water, decocting for 30-60 minutes, pouring out a medicinal liquid, and mixing the two medicinal liquids. The taking method comprises the steps: taking the medicinal liquid for two times, taking for one time each in the morning and in the evening, and taking after meals. The chrysanthemum is capable of clearing away heat and toxic materials, relieving restlessness and improving eyesight. The oyster is capable of tranquilizing with heavy material, and suppressing hyperactive liver for calming wind. The radix astragali is capable of invigorating qi for strengthening exterior, and removing sore and promoting tissue regeneration. The ligusticum wallichii is capable of promoting blood and qi circulation, and dispelling wind and relieving pain. The salvia miltiorrhiza is capable of promoting blood circulation to remove blood stasis, and clearing away the heart-fire and relieving restlessness. The rhizoma gastrodiae is capable of promoting blood circulation and removing wind, and tonifying spleen and regulating the middle warmer. The semen cassiae is capable of clearing liver, improving eyesight, smoothing intestine and relieving constipation. The tuber fleeceflower stem is capable of nourishing heart for tranquilizing mind, and dispelling wind and removing obstruction in the meridians. The composition has obvious curative effect on dizziness. Moreover, the production is simple, the raw materials are easy to obtain, and the price is low.
PURPOSE:To provide a non-irritant safe fat emulsion having excellent anti- inflammatory, analgesic and antipyretic activities compared with flurbiprofen, and low side effect, by using biphenylylpropionic acid derivative prepared by the esterification of flurbiprofen, as a component. CONSTITUTION:The objective fat emulsion contains one or more biphenylylpropionic acid dederivatives of formula I [R is group of formula II (R1 is H or 1-3C lower alkyl; R2 is 1-15C alkyl or 2-8C alkenyl; m is 0 or 1) or formula III(R3-4 is H or lower alkyl; n is 1-2)]. The group R is e.g. acetoxymethyl, propionyloxymethyl, etc. The fat emulsion is preferably composed of 0.01-30% (W/V) compound of formula I , 5-50% (W/V) soybean oil, 1-50pts.wt. of a phospholipid based on 100pts.wt. of the soybean oil, and a proper amount of water. The obtained preparation is administrable especially by intravenous injection and has long-acting as well as rapid activity.
A medical device known as an implantable therapeutic substance delivery device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and many other conditions. The therapeutic substance delivery device has a permanent magnet solenoid pump that is energy efficient, accurate, small, compatible with therapeutic substances, and has many other improvements. The implantable therapeutic substance delivery device has a housing, a therapeutic substance reservoir, a power source, electronics, and a permanent magnet solenoid pump. The therapeutic substance reservoir is configured to contain a therapeutic substance and is coupled to the housing. The power source is carried in the housing to power the electronics and solenoid pump. The electronics are coupled to the solenoid pump and the solenoid pump is coupled to the therapeutic substance reservoir. The permanent magnet solenoid pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion outlet at a programmed infusion rate. Many embodiments of the permanent magnet solenoid pump and its methods of operation are possible.
TIM\&SARA has a duration of 16 fifty-minute sessions and is organized in five modules. The first module (2 sessions) outlines the rationale for the program and establishes connections between group leaders and adolescents. The next module (2 sessions) focuses on helping adolescents to consider already existing goals, set new ones, and learn how to achieve goals to build up the motivation of the youth to learn and apply the material of the following modules. The third module (6 sessions) focuses on understanding the relations among cognitions, emotions, and behaviors, and teaching the participating youths how to identify and challenge negative cognitions. The forth module (5 sessions) trains the youth in assertive and social competent social behavior. Finally, the last session is a review session and includes a celebration. All parts of the program use illustrative, culturally relevant situations introduced by the participating adolescents.
S-1 is orally administered (40-60 mg according to the body surface, Bid) on day 1-14 of each 21-days cycle. Number of cycle: 6 cycles.
Antidepressant medications are among the most widely prescribed medications. However, only 35% to 45% of depressed patients have a complete remission of their illness when initially treated with these medications. Consequently, the Mayo Clinic psychiatric pharmacogenomic team developed a pharmacogenomic algorithm designed to improve the effectiveness and safety of antidepressant medications by providing guidance in medication selection and appropriate dosing. This algorithm has been incorporated into a new genotyping interpretative report. The pharmacogenomic algorithm is based on genotyping both copies of four informative genes. These four genes are: 1) the Cytochrome (P450 2D6) gene; 2) the Cytochrome (P450 2C19) gene; 3) the Serotonin Transporter gene (SLC6A4); and 4) the Serotonin 2A receptor gene (5HTR2A). The trial took place at the Franciscan Skemp Healthcare System in La Crosse, Wisconsin over the course of 12 months.
In the first phase of the study, a a three-day workshop (20 hours) online training on UP intervention will be provided to professionals. In the second phase, participants will implement the UP program that will consist of 8 treatment modules that include training in 5 core skills of emotional regulation: mindfulness training, cognitive flexibility, identification/oppositional behavior of emotional behaviors, interoceptive exposure and emotional exposure. Our team has adapted the UP to be implemented in 12 group sessions, one per week, lasting 2 hours, in specialized mental health care services of the national health system. Additional recommendations to adapt UP to alcohol addiction will be included.
A new prod. for the treatment of seborrhoea, pityriasis, alopecia, and capillary anoxemia contains the following vegetable extracts, horsetail extract 25-30% by vol, nasturtrium extract 23-25%, sage extract 23-25%, marigold extract 12-15%, ginseng extract 12-15%. The extracts are usually hydroglycolic, 1 kg of plants giving 5 kg of extract. A pref. solvent for the extracts is ethylene glycol ether mixed with an aq. alcoholic soln. of sodium dioctyl sulphosuccinate (2%), which has good penetrating properties. The horsetail extract supplies silicon to the compsn., while the marigold improves local circulation, acts as a peripheral vasodilator and stimulant, an antipellicular bactericide, and controls the sebaceous glands. The nasturtium extract regulates the sebaceous glands, reinforces the protecting sheath of the hair, and is a bactericide. Sage has antiseptic and oestrogenic properties, stimulating hair growth, while ginseng is a tonic and has a follicular -like activity.