anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Electrical Impedance Tomography recording is commenced 15 minutes prior to planned extubation. High Flow Nasal Therapy (HFNT) is commenced at least 10 minutes prior to planned extubation. At 5 minutes before extubation, the flow rate of HFNT should be established at 60 litres per min (or as high as can be tolerated by the participant) and the fraction of inspired oxygen (FiO2) set at 40 percent. Prior to extubation, endotracheal, infraglottic and supraglottic suctioning are performed. Then, the cuff is let down followed by immediate extubation with simultaneous application of HFNT. 10 minutes after extubation, the FiO2 is weaned in a protocolised manner to 21 percent - or as close to 21 percent as possible over 25 minutes. If the participant is safely weaned onto room air, the flow rate of HFNT is then reduced in a protocolised manner over 120 minutes: 60 minutes at 60 litres per minute (or the highest flow rate tolerated) and then 60 minutes at 30 Litres per minute.
CD25 monoclonal antibody (20mg/kg, day 1,4,8,15,21) will be administered combined with calcineurin inhibitors. The response should be evaluated at 3 and 4 weeks. If symptoms of aGVHD progress at 3 weeks or the patients have NR at 4 weeks, these patients will switch to other therapy. If patients achieved PR at 4 weeks, another cycle will be given.
PURPOSE: A cosmetic composition containing natural cereal powder is provided to physically remove skin dead cells and to absorb whitening ingredient. CONSTITUTION: A cosmetic composition for skin whitening contains natural cereal powder as a dead cell remover. The natural cereal is adzuki bean, chestnut cortex, brown rice, black rice, aurantii nobilis Pericarpium, oatmeal, or the rice bran. The composition further contains Rheum coreanum, Glycyrrhiza, or Persicae Semen extracts. The particular diameter of natural cereal powder is 10-1000 um. The composition contains the whitening ingredient in 0.05-5 weight%.
<P>PROBLEM TO BE SOLVED: To obtain a porphyran of being modified in physiological activities and physical properties, to provide a production method therefor and its uses.  <P>SOLUTION: The production of the porphyran being modified in physiological activities and physical properties, is carried out by removing a salt from a sulfate group in the porphyran by dissociating the salt, providing a free sulfuric acid group through dissociation of the salt of the sulfate group in the porphyran. Thereafter, the free sulfuric group is converted to a sulfate of prescribed salts. or the salt of the sulfuric acid group in the porphyran is treated with an ion-exchange resin to obtain the sulfate of the prescribed salts through ion exchange of the salt of the sulfate group, yielding the porphyran of being modified in physiological activities and physical properties. The porphyran is applicable to cosmetics, and foods and drinks all, having hyaluronidase activity-inhibiting action or the like, by adding it thereto.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Aromatherapy Group Aromatherapy will be carried out by spreading the essential oil in the laboratory with the help of a censer. For each censer, 6drops of essential oil mixture (oil mixture ratio, lemon, orange, frankincense oils; 2:2:2 ratio) and two censers will be used. Students will fill out the Introductory Information Form and State Anxiety Scale before being admitted to the laboratory. Students in the experimental group will be taken to the laboratory where aromatherapy is applied, intravenous catheter application will be demonstrated on a simulation model by the researcher during skill training, and each student will practice on the model once. At the end of the application, after students fill out the State Anxiety Scale again, they will be taken to a different room/laboratory and evaluated for skill learning.
This phase IIa randomized, controlled, parallel-group study will be conducted in 36 subjects with advanced PD who are treated with oral LD/CD at a stable dose and have predictable morning "OFF" periods and at least 2.5 hrs of daily "OFF" periods. The study will investigate the efficacy, PK, safety and tolerability of continuous SC infusion of 2 dosing regimens of ND0612H. Regimen 1 will employ continuous infusion for 24 hrs using a low infusion rate at night and a higher rate at daytime with supplemental administration of oral immediate release (IR) LD/CD in the mornings. During the inpatient period of about 3 days, the site staff will manage the administration and replacement of the infusions. On Day 4 subjects will be discharged home after they and their study partners have received training on the administration of the infusion. Subjects will then continue on a maintenance dose of the assigned ND0612 dosing regimen for the next 25 days. A safety visit will be performed 4 weeks after the last SC administration of the study drug.
NEW MATERIAL:A compound expressed by formula I (R1 represents acyl; R2 represents aryl). EXAMPLE:A compound expressed by formula II. USE:A fluorescent color former usable as a diagnostic and remedial agent for tumor. PREPARATION:A fatty acid expressed by the formula R-COOH (R represent aliphatic hydrocarbon) and 5-(4-aminophenyl)-10,15,20-tri(p-tolyl)porphyrin are dissolved in an aprotic organic solvent such as dichloromethane. To this solution is added a dehydrating condensing agent such as dicyclohexylcarbodiimide and amidation reaction is carried out while introducing an inert gas. The resultant reaction mixture is washed, dried and subjected to silica-gel chromatography using dichloromethane-hexane as an eluent to separate a crude product, which is further recrystallized from chloroform-methanol.
Patients who received up to 13 doses of recMAGE-A3 + AS15 ASCI. Study products were administered as intramuscular (IM) injections in the deltoid or the lateral region of the thigh (not in anatomical regions where lymph nodes had been excised): 5 doses of ASCI product at 3-week intervals, followed by 8 doses of ASCI product at 12-week intervals.
Disclosed are a peripheral blood TCR marker for IgA nephropathy, a detection kit thereof, and an application thereof. The marker comprises at least one of the proteins the sequences of which are shown in SEQ ID NO. 1-100. The present invention is based on a high-throughput sequencing method; only a small amount of peripheral blood needs to be taken to extract RNA, an immune big data library is established by processing samples, then high-throughput sequencing and TCR data analysis are performed; first a characteristic TCR sequence in peripheral blood of an individual suffering from IgA nephropathy is determined, and then a test result of a sample to be tested is aligned with the characteristic TCR sequence to thereby determine whether a patient has IgA nephropathy. In the present invention, a huge number of IgA nephropathy-specific TCR sequences can be compared simultaneously. Compared with detecting one or several markers alone, the present invention has higher specificity and accuracy, and improves diagnostic efficiency.
Patients admitted for a venous thromboembolic event related to their cancer will be included A data collection will be realized. Patients admitted between 2017 and 2019 at Saint-Etienne University Hospital, Louis-Mourier Hospital (AP-HP) and Amiens University Hospital.
Chronic wasting disease (CWD) is a naturally occurring prion disease in cervids that has been rapidly proliferating in the United States. Here, we investigated a potential link between CWD infection and gut microbiome by analyzing 50 fecal samples obtained from CWD-positive animals of different sexes from various regions in the USA compared to 50 CWD-negative controls using high throughput sequencing of the 16S ribosomal RNA and targeted metabolomics. Our analysis reveals promising trends in the gut microbiota that could potentially be CWD-dependent, including several bacterial taxa at each rank level, as well as taxa pairs, that can differentiate between CWD-negative and CWD-positive deer. Through machine-learning, these taxa and taxa pairs at each rank level could facilitate identification of around 70% of both the CWD-negative and the CWD-positive samples. Our results provide a potential tool for diagnostics and surveillance of CWD in the wild, as well as conceptual advances in our understanding of the disease.IMPORTANCEThis is a comprehensive study that tests the connection between the composition of the gut microbiome in deer in response to chronic wasting disease (CWD). We analyzed 50 fecal samples obtained from CWD-positive animals compared to 50 CWD-negative controls to identify CWD-dependent changes in the gut microbiome, matched with the analysis of fecal metabolites. Our results show promising trends suggesting that fecal microbial composition can directly correspond to CWD disease status. These results point to the microbial composition of the feces as a potential tool for diagnostics and surveillance of CWD in the wild, including non-invasive CWD detection in asymptomatic deer and deer habitats, and enable conceptual advances in our understanding of the disease.
The application discloses a method and composition of treating MPSI based upon LEAPER technique. The method comprises steps of introducing a construct containing an adenosine deaminase arRNA of editing target RNA or editing the arRNA into the cells, wherein the arRNA contains complementary RNA sequence hybridized with the target RNA. Moreover, the arRNA affects adenosine deaminase (ADAR) of RNA to remove the amino group from the targeted adenosine within the target RNA. The arRNA is a cyclic RNA or a RNA capable of forming a cyclic RNA. The method is directed to the cyclic RNA designed for aiming W402 sites. The whole editing ability is enhanced to about 3 times before optimization. At the same time, the proportion, for the editing efficiency edited at the non-target bit points relative to the editing efficiency edited at the target bit points, is reduced to the percentage lower than 0.5% after optimization from 7% before optimization.
PROBLEM TO BE SOLVED: To obtain a new compound having excellent antibacterial activity, capable of exhibiting excellent antibacterial activity against various bacteria including especially mycobacteria and useful as a prophylactic or a treating agent of infectious diseases caused by these bacteria, and separated from a microbial culture liquid. SOLUTION: A compound A-500359E of the formula. The compound of the formula can be obtained by culturing a microorganism belonging to the genus Streptomyces, producing the compound (preferably, the strain of Streptomyces griseus SANK60196 or the like which has been collected and separated from soil of Tsukuba mountain in Ibaraki Prefecture), and harvesting the compound from the culture product. As the culture medium for the culturing, a synthetic medium or a natural medium appropriately containing components selected from carbon sources, nitrogen sources, inorganic ions, organic nutrients and the like. As the nutrient, the one conventionally used for culturing the microbial strains of fungus or actinomycetes can be used. As medium culture, commonly used aerobic culture (solid culture, shaking culture, submerged culture or the like) can be used.
Borderline resectable pancreatic adenocarcinoma infiltrates into adjacent vascular structures to an extent such that complete macroscopic resection is technically feasible, but an R0 resection poses a challenge when surgery is the primary therapy. Therefore, a different management strategy may be beneficial.

The primary outcome of the PANCREAS trial is defined as the proportion of eligible patients enrolled in the study over an 18-month period and the proportion of patients who complete the protocol (neoadjuvant therapy and pancreatectomy). Certain modifications of the neoadjuvant therapy protocol are expected and allowed, and the primary feasibility outcome will be one of the following: stop, main study non-feasible; continue with protocol modifications; or continue without modification. A safety analysis will be performed after first 15 patients are enrolled and complete neoadjuvant therapy and surgery. Patients enrolled in this trial will undergo interventions in the following order: neoadjuvant chemotherapy, re-staging CT scan, pancreatectomy and adjuvant chemotherapy. Postoperative mortality will be recorded up to 90 days after surgery. Patients will be followed every four months with a CT scan of the chest/abdomen for two years after resection or until evidence of disease recurrence. Patients who do not undergo surgical resection will be followed for two years after accrual (duration of study period) or until evidence of disease progression or death.
A fiber-rich diet is considered beneficial for gut health. An inflamed gut with a dysbiotic bacterial community can result in altered fiber metabolism depending on the fiber's physicochemical properties. This study examined the effect of fiber's physicochemical properties on fiber fermentation in the presence of healthy and colitis-associated bacteria. Sixteen fibers with different levels of solubility, complexity, and fermentation rate were used in in vitro fermentation with healthy human gut bacteria. Resistant maltodextrins (RMD), pectin (HMP), inulin (ChIn), and wheat bran (WB) were selected for fermentation using ulcerative colitis (UC)-associated bacteria to assess bacterial dysbiosis effect. UC-associated gut microbiota showed a significant reduction in α-and β-diversity indices compared to healthy-associated microbiota. The differences in the gut microbiota composition and diversity between the donors resulted in decreased fermentation rates with UC-associated bacteria. Fiber fermentation metabolites, short-chain fatty acids (SCFA) and gas production were significantly lower in the presence of UC-associated bacteria for all four fibers tested. Overall, we conclude that dietary fiber properties and microbial dysbiosis are influential in fiber fermentation and metabolite production in the gut.
BACKGROUND AND AIMS: Pain is a cardinal symptom in inflammatory bowel disease [IBD]. An important structure in the transduction of pain signalling is the myenteric plexus [MP]. Nevertheless, IBD-associated infiltration of the MP by immune cells lacks in-depth characterisation. Herein, we decipher intra- and periganglionic immune cell infiltrations in Crohn´s disease [CD] and ulcerative colitis [UC] and provide a comparison with murine models of colitis.
METHODS: Full wall specimens of surgical colon resections served to examine immune cell populations by either conventional immuno-histochemistry or immunofluorescence followed by either bright field or confocal microscopy. Results were compared with equivalent examinations in various murine models of intestinal inflammation.
RESULTS: Whereas the MP morphology was not significantly altered in IBD, we identified intraganglionic IBD-specific B cell- and monocyte-dominant cell infiltrations in CD. In contrast, UC-MPs were infiltrated by CD8+ T cells and revealed a higher extent of ganglionic cell apoptosis. With regard to the murine models of intestinal inflammation, the chronic dextran sulphate sodium [DSS]-induced colitis model reflected CD [and to a lesser extent UC] best, as it also showed increased monocytic infiltration as well as a modest B cell and CD8+ T cell infiltration.
CONCLUSIONS: In CD, MPs were infiltrated by B cells and monocytes. In UC, mostly CD8+ cytotoxic T cells were found. The chronic DSS-induced colitis in the mouse model reflected best the MP-immune cell infiltrations representative for IBD.
Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.
The invention relates to a sodium valproate granulate having reduced hygroscopicity. Said granulate contains a sodium salt of valproic acid together with 5 to 30 %-mass proportion of valproic acid sodium salt to stabilizer. The stabilizer is selected from a group of substances containing citric acid and hydrates thereof, in particular the monohydrate, malic acid and tartaric acid. The invention also relates to a novel method for the production of said sodium valproate granulate. The granulate according to the invention can be made into oral pharmaceutical forms, in particular rapid-release tablets. Said granulates can also be used to produce tablets having retarded release characteristics.
Only observe the patient's baseline, intraoperative hypothermia, postoperative complications, and other indicators, and collect data through the electronic Data Capture System to optimize existing intraoperative hypothermia prediction model. The estimated sample size is 1000 cases by the incremental learning curve calculating.
Regular exercise is known to be a successful strategy for improving several facets of health and maintaining body weight. However, many people are not engaging in enough exercise, and some may not be achieving maximum benefits from the exercise that they already do. Performing exercise in the overnight fasted state has been shown to reduce energy intake over the course of a single day, without any compensatory reductions in free-living energy expenditure. Despite these promising findings, it is likely that not every member of the population is logistically able to perform exercise in the morning due to various work, family and social commitments, and exercise in the evening may be a logical alternative for these individuals. Whether the beneficial effects of overnight fasted exercise can be observed at an alternative time of the day (i.e. the evening) is unknown.

Therefore, the investigators are interested in examining the compensatory appetite and energy intake responses following a bout of evening exercise performed after an extended (7 hour) period of fasting. Exercise performance will also be assessed as a marker of voluntary energy expenditure, which if reduced, has the potential to compensate for the reduced energy balance induced by fasted exercise.
Rodents represent the single largest group within mammals and host a diverse array of zoonotic pathogens. Urbanisation impacts wild mammals, including rodents, leading to habitat loss but also providing new resources. Urban-adapted (synanthropic) rodents, such as the brown rat (R. norvegicus), black rat (R. rattus), and house mouse (Mus musculus), have long successfully adapted to living close to humans and are known carriers of zoonotic pathogens. Two important enteric, zoonotic protozoan parasites, carried by rodents, include Cryptosporidium and Giardia. Their environmental stages (oocysts/cysts), released in faeces, can contaminate surface and wastewaters, are resistant to common drinking water disinfectants and can cause water-borne related gastritis outbreaks. At least 48 species of Cryptosporidium have been described, with C. hominis and C. parvum responsible for the majority of human infections, while Giardia duodenalis assemblages A and B are the main human-infectious assemblages. Molecular characterisation is crucial to assess the public health risk linked to rodent-related water contamination due to morphological overlap between species. This review explores the global molecular diversity of these parasites in rodents, with a focus on evaluating the zoonotic risk from contamination of water and wasterwater with Cryptosporidium and Giardia oocysts/cysts from synanthropic rodents. Analysis indicates that while zoonotic Cryptosporidium and Giardia are prevalent in farmed and pet rodents, host-specific Cryptosporidium and Giardia species dominate in urban adapted rodents, and therefore the risks posed by these rodents in the transmission of zoonotic Cryptosporidium and Giardia are relatively low. Many knowledge gaps remain however, and therefore understanding the intricate dynamics of these parasites in rodent populations is essential for managing their impact on human health and water quality. This knowledge can inform strategies to reduce disease transmission and ensure safe drinking water in urban and peri‑urban areas.
Objective: Recent studies on Long COVID found that patients report prominent emotional distress and significant correlations between distress and cognitive performance have been identified, raising the question of how to manage or treat these issues. To understand psychological functioning in Long COVID further, this study examined personality responses on the Personality Assessment Inventory (PAI) to compare psychological functioning in a Long COVID group with a post-concussion syndrome (PCS) group, a syndrome with a significant psychological component. Participants and methods: Participants included 201 consecutive Long COVID outpatients (Mean age = 48.87 years, mean education = 14.82, 71.6% Female, 82.6% White) and a comparison group of 102 consecutively referred PCS outpatients (Mean age = 46.08, mean education = 14.17, 63.7% Female, 88.2% White). Effect sizes and t-tests were calculated using the PAI validity, clinical, interpersonal, and treatment consideration scales as well as clinical subscales. Results: The results replicated earlier findings on the PAI in Long COVID by demonstrating that both Long COVID and PCS groups had the highest mean elevations on SOM and DEP scales but no statistically significant between group differences in mean scale elevations. Results support similarities in psychological functioning between Long COVID and PCS patients emphasizing the importance of evaluating psychological functioning in neuropsychological evaluations for these populations. Further, results suggest that psychological treatment strategies for PCS patients may be helpful for Long COVID patients, but more research is needed.
PURPOSE:To obtain the subject composition, having a refractive index close to that of a filler and excellent in strength and water resistance by containing a specific ingredient in a diacrylate or dimethacrylate having fluorine-containing bisphenol group as a skeleton in a specified proportion. CONSTITUTION:The subject composition obtained by containing one or more ingredients selected from (B) an aliphatic mono- to diacrylate or aliphatic mono- to dimethacrylate, (C) a filler and (D) a photopolymerization initiator in (A) a compound expressed by the formula (R is H or methyl). The amounts of the components are 100 pts.wt. ingredient (A), 0-300 pts.wt. ingredient (B) and further 0-500 pts.wt. ingredient (C) and 0-3 pts.wt. ingredient (D) based on 100 pts.wt. total amount of the ingredients (A) and (B). Since the composition has a low refractive index with excellent light transmitting properties and is capable of efficiently photo-setting even to the deep filled part and the resultant cured bodies are excellent in water resistance and mechanical properties, the composition suitable as a substitute material for tooth hard tissues, such as hard resin artificial teeth, is obtained.