anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
ABSTRACT A table that is useful alone and in combination with a tray and/or other inserts supported atop the table. The table is of a unitary molded plastic construction and is configured for nested stacking with like tables for convenient and compact storage and handling. The table has a top surface of regular polygonal shape with four truncated corners, and a plurality of legs depending from the table top at respective ones of the truncated corners. The legs, going from top to bottom, diverge outwardly with each being in the form of a channel that opens inwardly for nested receipt of a corresponding leg of a subjacent table of like construction. The table top has an upstanding marginal rim extending along the peripheral edge of the top surface thereof, and the marginal rim functions to prevent objects from rolling or sliding off the top surface and/or as containment structure for an insert such as a decorative panel and/or a removable tray that may have a design printed thereon. The table and tray combination can be stacked in nested relationship with like tray and table combinations.
The present invention relates to an externally applied medicine for treating jaundice of liver diseases, more specifically to an externally applied medicine which have multiple preparations and is prepared by matching main Chinese herbal medicines, such as creeping dichondra herbs or elodea-like St. John wort herbs, etc. with other Chinese herbal medicines. The externally applied medicine comprises according to weight mixture ratios as follows: 10 to 50 portions of creeping dichondra herb, 8 to 40 portions of radix ophiopogonis, 8 to 35 portions of decumbent bugle herb and 15 to 60 portions of cairo morningglory root or leaf. The externally applied medicine has the functions of clearing heat, removing toxicity, strengthening the spleen, promoting urination, calming the liver, treating jaundice, stimulating circulation to end stasis and cooling blood to relieve depression. A therapeutic method is characterized in that medicinal material is pounded into medicinal mud which is filled into a bag; the big is stuck on the umbilical part, medicinal gas enters a human body and passes through meridian and vessels to remove the toxicity, carry out dredging and effectively and quickly suppress viruses so as to enhance the immunizing power of patients. Compared with oral administration medicines, the present invention treats and protects the liver without damaging the stomach and the intestine and does not damage vital qi and is favorable to the absorption of the medicines of the patients; besides, the present invention has no incompatibility with any oral administration medicines and facilitates the restoration of the physical strength of the patients.
This dose adaptive study is planned to treat up to 20 patients in each starting dose cohort, with a maximum of three starting dose cohorts. The doses planned to be assessed are 1, 2, 4, 6 and 8 mg, however, the maximum starting dose will be 4 mg. The starting dose of the first cohort will be 1 mg; the first cohort will include at least five patients. After the first fifteen patients have been treated for 4 weeks, the results will be reviewed by a Data Review Committee. An extension phase (Part B) is planned for those subjects completing the initial study and fulfilling specific eligibility criteria (symptoms control, willingness to participate, safety and tolerability).
Fructose can be found in the diet as free fructose, in sucrose or as polymer structure in fructans. Absorption varies and occurs more rapidly in the presence of glucose than for free fructose because glucose cotransport is involved in the uptake of fructose. Therefore, when fructose is in excess of glucose, it is regarded as a FODMAP. The fructose concentration used in this study is 100g/L.
Wild Garlic (Bear's or Forest Garlic,  Allium ursinum ) can be combined with cultivated high-allicin garlic ( Allium sativum ) and extracts of the same to take advantage of the previously unknown synergism of preparations made from these two garlic species. There is a substantial cost savings over the use of pure, Wild Garlic and an elimination of the side effects found with the chronic ingestion of high levels of cultivated allicin-rich garlic ( Allium sativum ). The resulting combination has demonstrated benefits with regard to blood lipids regulation in individuals in need thereof that are two or more times that expected from the use of either garlic species taken singularly. Blood pressure regulating benefits are maintained or improved, the odor-causing potential of high-allicin garlic is reduced, and significant improvements are found in the areas of total, LDL, and VLDL cholesterol and triglycerides, benefits far beyond the merely additive. HDL cholesterol levels also are improved. It is to be expected that these benefits, in addition, can be extended through the concurrent intake of folic acid, red yeast rice extracts and other compounds proposed for improving cardiovascular health. Still further, a variety of defined delivery approaches, including, but not limited to controlled releases, especially those including mucoadhesive, can be utilized to improve the effects taught herein.
The invention discloses a traditional Chinese medicinal preparation for treating postpartum haemostasis, and preparation method. The preparation is prepared from the following main raw materials, by weight, 5-15 parts of root of Japanese Thistle Herb, 8-17 parts of Gynura japonica, 6-12 parts of Herb of Ramose Scouring Rush, 5-15 parts of Ageratum conyzoides L, 6-10 parts of Radix Platycodonis, 5-15 parts of Herba Taraxaci, 10-14 parts of Rhizoma Coptidis, 7-13 parts of Tupidanthus calyptratus Hook. f. et Thoms., 8-14 parts of Radix Astragali, 3-9 parts of Radix Ophiopogonis, 4-11 parts of Poria cocos, 9-16 parts of Common Goldenrop, 3-8 parts of amber, 8-15 parts of Dioscorea nipponica Makino, 2-4 parts of cutworm, 6-8 parts of Common Dysosma Rhizome, 5-7 parts of Gerbera anandria and 15-18 parts of honeysuckle flower. The traditional Chinese medicinal preparation is based on a principle of postpartum haemostasis of traditional Chinese medicines. Medicinal materials selected in the invention have haemostasis and anti-inflammation efficacies, and the preparation aims at postpartum haemostasis syndrome differentiation treatment, and is a composition for realizing simultaneous treatment of principal and subordinate symptoms. The traditional Chinese medicinal preparation has an extremely good treatment effect on postpartum haemostasis.
A composition is provided for relieving premenstrual syndrome. The composition comprises about 5% to about 95% by weight of a tribulus terrestris extract and about 5% to about 95% by weight of one or more herbal extracts selected from organic white willow extract, Red raspberry leaf extract, Chaste tree berry extract, Cramp bark extract, and Gingko biloba extract. The composition further comprises dehydroepiandrosterone, amino acids, vitamins and derivatives thereof, minerals and derivatives thereof, carbohydrates, citric acid, natural flavors, stevia, juice powder, maltodextrin, and silicon dioxide. The vitamins and derivatives thereof comprise, for example, vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin B9, vitamin B7, vitamin C, vitamin D3, and d-calcium pantothenate. The minerals comprise, for example, calcium, magnesium, manganese, sodium, and potassium. The ingredients are mixed in a liquid carrier and administered as a hot or cold beverage.
INCB123667 will be administered at the recommended dose or doses for expansion (RDE\[s\]) for advanced or metastatic solid tumors. Participants with gynecologic tumors (epithelial ovarian/fallopian/primary peritoneal carcinoma ) will enroll in this group.
The present invention pertains to delivery systems for the localized administration of a medicament to the upper respiratory tract. The delivery system comprises: (a) a safe and effective amount of a medicament useful for treating the upper respiratory tract; (b) an ionic polysaccharide; and (c) a cross-linking agent. The present invention provides for the controlled, in situ formation of a thin, bioadhesive film which may bind to the buccal epithelial cells which form the surface of said upper respiratory tract. Said film formation occurs when the delivery system of the present invention comprising a medicament, an ionic polysaccharide and a cross-linking agent, in a pharmaceutically acceptable carrier, is slowly ingested by dissolution through salivation of the pharmaceutically acceptable carrier. By a series of cross-linking reactions, the cross-linking agent polymerizes the ionic polysaccharide to a film in the form of aggregates, which bind to the buccal epithelial cells in the upper respiratory tract. During the in situ cross-linking reaction, the medicament becomes entrapped in the bioadhesive polymer aggregate and thereafter is gradually released, i.e., becomes available through dissolution.
Cocaine is a strong central nervous system stimulant that is widely abused throughout the United Sates. Due to its widespread use, it is important to develop an effective treatment for cocaine dependence. Motivational Interviewing (MI) is often effective when combined with drug treatment. Baseline condition (e.g., abstinence status) and population type (e.g., ethnicity and gender) often affect how an individual responds to treatment for drug dependence. The purpose of this study is to determine the influence of baseline status and population type on treatment response in cocaine dependent individuals. In addition, this study will examine how various cocaine abuse medications target different neuronal systems, withdrawal symptoms, and relapse to drug use.

This study will take place in two phases. Phase I will last 4 weeks; participants will receive MI and undergo contingency-based urine tests in order to achieve the desired baseline condition. Phase II will last 12 weeks. Participants in Phase II will be randomly assigned to receive one of four treatments: 1) 50 mg naltrexone, 2) 800/200 mg levodopa/carbidopa, 3) 400 mg modafinil, or 4) placebo. During Phase II, all participants will receive psychotherapy and contingency management. Participants will complete urine drug screening tests 3 times each week. Follow-up study visits will occur between 3 and 6 months following Week 12, and will include objective and self-reported drug use.
Gas-inflatable plastic particles are made by forming a solution of a normally solid thermoplastic resin and a solid, thermally stable substance capable of giving off a gas by simple chemical reaction with a diffusant, the solvent being inert with respect to the resin and the gas generator, and converting the solution into a multiplicity of plastic particles containing the unchanged gas generator therein, and ranging in ultimate particle diameter from 0.1 to 100 microns.  Specified plastic materials are polyvinyl alcohol and acetate, cellulose esters, polystyrene, polyvinyl chloride and polyethylene. The gas generator may suitably be Al3C4, used with water, or an alkali metal or alkaline earth metal carbonate or bicarbonate used with an acid diffusant. Alternatively a solid acidic substance, e.g. an organic acid or anhydride, a pyrosulphite, pyrosulphate, bisulphite, bisulphate or acidic phosphate may be encapsulated with a carbonate or bicarbonate, with water being used as diffusant.ALSO:A slimming aid comprises a wafer containing plastic microbeads bound by edible gelatin.  These plastic beads are permeable to aqueous acid, and contain a substance which will react with acid to give a gas, e.g. a bicarbonate when swallowed, these will inflate by the action of stomach acid and thus counteract hunger pangs.  The exemplified plastic (Example 2) is polyvinyl alcohol.ALSO:Gas-inflatable plastic particles are made by forming a solution of a normally solid thermoplastic resin and a solid, thermally stable substance capable of giving off a gas by simple chemical reaction with a diffusant, the solvent being inert with respect to the resin and the gas generator, and converting the solution into a multiplicity of plastic particles containing the unchanged gas generator therein, and ranging in ultimate particle diameter from 0.1 to 100 microns.  Specified plastic materials are polyvinyl alcohol and acetate, cellulose esters, polystyrene, polyvinyl chloride and polyethylene.  The gas generator may suitably be Al3C4, used with water, or an alkali metal or alkaline earth metal carbonate or bicarbonate used with an acid diffusant. Alternatively a solid acidic substance, e.g. an organic acid or anhydride, a pyrosulphite, pyrosulphate, bisulphite, bisulphate or acidic phosphate may be encapsulated with a carbonate or bicarbonate, with water being used as diffusant.  These inflatable particles may be used as insulating coating compositions and may be applied by spraying, dipping or brushing. In Example 6 polystyrene beads containing Al4C3 are sprayed onto steel piping, and water vapour permeating the polymer reacts to generate methane, thus forming a heat-insulating inflated plastics coating.  The coating may be heated to increase the permeability of the polymer.
If tolerability is demonstrated in the 150mg treatment arm following the 3+3 trial design, up to 6 infants will then be enrolled and receive 150mg of tobramycin solution for inhalation every 12 hours. The same monitoring procedures will be performed in this treatment arm as in the prior.
NEW MATERIAL:An antisuperoxide dismutase monoclonal antibody. USE:An immunological adsorbent. PREPARATION:An antisuperoxide dismutase (SOD) antibody obtained by subjecting a splenic cell collected from a mammal immunized with a superoxide dismutase (SOD) originating from mammals and a myelomatous cell of a mammal to the fusion, and cultivating the resultant hybridoma cells. The fusion of the splenic cell with the myelomatous cell is achieved by bringing both into contact in the presence of a fusion promoter, e.g. polyethylene glycol. The advantage of this method is as follows; A supply source for a specific antiSOD antibody uncontaminated by an antibody reactive with any of other antigen determining groups against SOD to be used, and by antigen impurity containied in the SOD pharmaceutical solution to be used. A large amount of a desired anti SOD antibody is easily obtained.
This is a multi-center trial, which will be conducted in a total of 240 patients (120 patients in each treatment group). Patients attending the out-patient setting of traumatology and orthopedic departments of the study centers will be screened for lumbar pain and spasm by clinical and radiological examination for inclusion. In this study, it has been planned to enroll a total of 240 patients with 120 patients in each group. The total duration of treatment will be 14 days. Patients will be screened for baseline parameters and will then be randomized, as per the predetermined randomization schedule, into two groups. Patients will be treated with either Eperisone-HCl (Myonal) or placebo for a period of 14 days. After the baseline-screening visit (Day 1), the patients would be asked to follow up on day 3, day 7, and day 14. During each visit, a complete general examination and clinical evaluation of efficacy parameters would be done. Adverse events would be monitored during the study period and would be recorded in the Case Report Form (CRF). At the end of the treatment, Global Assessment of Response to Therapy by Physicians and Patients (PGART) would be done for efficacy and tolerability separately.
Patients in this arm receive usual care for dual-diagnosis symptoms of mental health and substance use. They receive 5 check-in calls from a care manager to assess safety.
This study's aim is to describe the imaging findings in pregnant patients undergoing emergent MRI for suspected acute appendicitis, and the various alternative diagnoses seen on those MRI scans. This is a single center retrospective analysis in which we assessed the imaging, clinical and pathological data for all consecutive pregnant patients who underwent emergent MRI for suspected acute appendicitis between April 2013 and June 2021. Out of 167 patients, 35 patients (20.9%) were diagnosed with acute appendicitis on MRI. Thirty patients (18%) were diagnosed with an alternative diagnosis on MRI: 17/30 (56.7%) patients had a gynecological source of abdominal pain (e.g. ectopic pregnancy, red degeneration of a leiomyoma); 8 patients (26.7%) had urological findings such as pyelonephritis; and 6 patients (20%) had gastrointestinal diagnoses (e.g. abdominal wall hernia or inflammatory bowel disease). Our conclusions are that MRI is a good diagnostic tool in the pregnant patient, not only in diagnosing acute appendicitis, but also in providing information on alternative diagnoses to acute abdominal pain. Our findings show the various differential diagnoses on emergent MRI in pregnant patients with suspected acute appendicitis, which may assist clinicians and radiologists is patient assessment and imaging utilization.
PURPOSE: To eliminate a fault wherein stress may be generated in a manufactured artificial denture base caused by the difference between heat shrinkage of a resin and heat shrinkage of a plaster used as an indirect work and the artificial denture base is deformed during a mold is released to become inferior adaptability when an artificial denture base is prepd. by using the resin such as acrylics. CONSTITUTION: A dental prosthesis with good adaptability can be prepd. as heat shrinkage of a resin for an artificial denture base can be made close to heat shrinkage of a plaster for preparing the dental prosthesis by using the resin for the artificial denture base contg. 1-20 pts.wt. polymn. initiator with a heat decompsn. temp. in the range from ordinary temp. to 65 deg.C to 100 pts.wt. monomer.
Fathers in this study are required to take an Eligibility survey. If they meet the required eligibility criteria, the survey will gather further information including screening factors associated with domestic violence that, if checked, will be flagged for further assessment by personal contact with our Case Management Supervisor. This form also will enable the registrant to identify which class format he wishes to attend-a live R3 Academy or a livestream workshop via a video conferencing platform. For the purpose of this study, the live or in-person modality is considered the control group and the livestream workshop is considered the treatment group. The R3 Academy curriculum is the same for each group, only the modality of curriculum delivery is different. Courses are a total of 24 hours and are split into either 6- or 12-week formats. Incentives for program completion include a $50 gift card that is offered to those who complete at least 90% of the program. In addition to the Eligibility survey, participants are asked to take a pre-survey before starting the class, a post-survey immediately following class completion, and a 4-month follow-up survey. If participants complete all three surveys they are eligible for an additional $25 gift card which they can receive even if they did not reach 90% completion.

As stated previously, entry into treatment or control groups is determined at enrollment. At the time of the impact analysis, propensity score matching (PSM) comparison groups will be formed-this statistical analysis will match up similar participants from each group to allow for comparison across conditions. PSM allows researchers to estimate differences between treatment and control groups in non-randomized samples. PSM will allow us to directly compare matched cases-meaning that the treatment and control groups will have a similar distribution of sociodemographic and sociocultural characteristics. This allows us to consider how outcomes vary between treatment and control groups, while accounting for the potential self-selection into different program groups. Participants will be matched across multiple metrics, including: racial/ethnic identity, sex/gender, income, education level, language of instruction, number of children, employment status, age, marital status, and residential status. As clients may choose one program delivery modality over another due to work, childcare availability, or time, measures will be included for work schedule, availability of social support, work flexibility, and work-family stress.
PURPOSE: To obtain a composition including a specific naphthoic acid derivative, and facilitating a suitable supply of the oxygen necessary for metabolism to a human tissue by changing the compatibility of hemoglobin to oxygen. CONSTITUTION: This composition includes an effective amount of a compound of formula I [R is H, an alkyl, an aryl or an aminoalkyl; R1 is H, an alkyl, NH2 , NR3 R4 (R3 and R4 are each H or an alkyl, or form a cyclic amino by bonding each other with N); R2 is H, an acyl, an aminoacyl, an alkyl (substituted by an aryl, a cycloalkyl, an alkoxy, etc.); A is H, halo, CF3 , OH, a group of formula II, an aminoalkyl, an aryl, an acyl, etc.] or its salt, e.g. 5-fenetoxy-3- hydroxy-2-naphthoic acid admixed with a pharmaceutically acceptable carrier. The compound inhibits an enzyme of 2,3-diphosphoglycerate phosphatase and allows 2,3-diphosphoglyceric acid to e maintained and accumulated in red blood corpuscles accompanied with holding and enhance of oxygen availability.
Upper trapezius (UT) excitation redistributes with experimentally-induced muscle pain, fatigue, and repeated contractions. Excitation distribution variability is proposed to reduce the likelihood of shoulder pain and pathology by reducing cumulative stress on musculoskeletal structures. While the middle (MT) and lower (LT) trapezius are pivotal in scapular stabilization, it remains unclear whether they display similar excitation distribution variability with repeated or increasing contraction intensity. We determined if excitation distribution of the UT, MT, and LT differ: 1) during isometric contractions at different intensities (30 % and 60 % of maximum voluntary isometric contraction (MVIC)); and 2) with repeated contractions at 60 % MVIC. Nineteen individuals completed MVICs and submaximal contractions for the UT, MT, and LT while high-density electromyography was collected. Statistical parametric mapping t-tests were performed between intensities and the 1st and 5th repetition at 60 % MVIC. UT, MT, and LT excitation distribution changed with increasing contraction intensity in 358 (∼92 % of the map), 54 (∼14 %), and 270 pixels (∼70 %), respectively. No pixels exceeded significance with repeated contractions for any muscle. Barycentre analyses revealed no significant results. These results suggest that regions of the trapezius muscle use different neuromuscular strategies in response to changes in contraction intensity and repeated contractions.