anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition containing vegetable peptone for promoting stem cell proliferation is provided to save manufacturing cost. CONSTITUTION: A serum-free composition for culturing stem cells contains vegetable peptone as an active ingredient. The vegetable peptone is obtained by acid, alkali, enzyme, high pressure, heat, or physical treatment. The vegetable peptone is soy peptone, wheat peptone, broadbean peptone, potato peptone, pea peptone, papic soy peptone, or lupin peptone. A composition for improving skin condition contains culture liquid in which stem cell is cultured in a serum-free media containing the vegetable peptone and then stem cells are removed. The stem cell is mesenchymal stem cells derived from human umbilical cord blood, skin-derived stem cells, or adipose-derived stem cells.
PURPOSE:To obtain a skin cleaning agent for bathing, providing the skin with nourishment, removing attached fat and casein from the skin after a bath and giving refreshing feeling to the body, by compounding dried milk and borax powder at a specific weight ratio. CONSTITUTION:3-10pts.wt. of dried milk (e.g. skim milk powder) is thoroughly mixed with 1pt.wt. of borax powder and the obtained cosmetic is thrown into warm water and agitated. The flotation of the skim milk powder is inhibited by the addition of borax powder to enable the homogeneous mixing of the skim milk powder in warm water. The deposition of oil and fat or scale to the inner surface of a bathtub can be prevented by the action of borax to keep the bathtub in clean state. The effect is remarkable in a bathtub made of stainless steel or plastic.
INTRODUCTION: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with significant clinical implications. The potential influence of lipid-lowering therapies, specifically PCSK9 inhibitors (PCSK9i) and HMG-CoA reductase inhibitors (statins), on AF risk remains a topic of interest. This mendelian randomization (MR) study aimed to elucidate the causal relationship between genetically predicted inhibition of PCSK9 and HMG-CoA reductase and the risk of AF.
METHODS: Utilizing publicly available, summary-level genome-wide association study data, we employed single-nucleotide polymorphisms associated with lower LDL-C levels as instruments for gene-simulated inhibition of PCSK9 and HMG-CoA reductase. Multiple MR techniques were applied to estimate the causal effects, and sensitivity analyses were conducted to validate the results.
RESULTS: Genetically predicted inhibition of PCSK9 demonstrated a reduced risk of AF, with an odds ratio (OR) of 0.92 (95% CI: 0.85-0.99, p = 0.01) using the inverse variance-weighted (IVW) method. In contrast, the inhibition of HMG-CoA reductase did not exhibit a statistically significant association with AF risk (IVW: OR = 1.11, 95% CI: 1.00-1.22, p = 0.05).
CONCLUSION: Our MR study suggests that genetically predicted inhibition of PCSK9, but not HMG-CoA reductase, is associated with a lower risk of AF. These findings provide evidence for a causal protective effect of PCSK9i on AF and support the use of PCSK9i for AF prevention in patients with dyslipidemia. Further studies are needed to elucidate the mechanisms underlying the differential effects of PCSK9i and statins on AF and to confirm the clinical implications of our findings.
Intralipid® 20% (A 20% I.V. Fat Emulsion) is a sterile, non-pyrogenic fat emulsion intended as a source of calories and essential fatty acids for use in a pharmacy admixture program. It is made up of 20% Soybean Oil, 1.2% Egg Yolk Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust the pH so that the final product pH is 8. pH range is 6 to 8.9. 

Intralipid 20% Pharmacy Bulk Package is not intended for direct infusion. It is a sterile dosage form which contains several single doses for use in preparation of three-in-one or total nutrient admixtures (TNAs) in a pharmacy admixture program.

The soybean oil is a refined natural product consisting of a mixture of neutral triglycerides of predominantly unsaturated fatty acids with the following structure: 

Whereare saturated and unsaturated fatty acid residues. 

The major component fatty acids are linoleic acid (44-62%), oleic acid (19-30%), palmitic acid (7-14%), α-linolenic acid (4-11%) and stearic acid (1.4-5.5%)1. These fatty acids have the following chemical and structural formulas: 

Purified egg phosphatides are a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These phospholipids have the following general structure: 

contain saturated and unsaturated fatty acids that abound in neutral fats. R3 is primarily either the choline or the ethanolamine ester of phosphoric acid. 

Glycerin is chemically designated C3H8O3 and is a clear colorless, hygroscopic syrupy liquid. It has the following structural formula: 

Intralipid 20% (A 20% I.V. Fat Emulsion) has an osmolality of approximately 350 mOsmol/kg water (which represents 260 mOsmol/L of emulsion) and contains emulsified fat particles of approximately 0.5 micron size. 

The total caloric value, including fat, phospholipid and glycerin, is 2.0 kcal per mL of Intralipid 20%. The phospholipids present contribute 47 milligrams or approximately 1.5 mmol of phosphorus per 100 mL of the emulsion. 

The primary plastic container (BiofineTM) is made from multilayered film specifically designed for parenteral nutrition drug products. The film is polypropylene based comprising three co-extruded layers. It contains no plasticizers and exhibits virtually no leachables. The container does not contain DEHP (di(2-ethylhexyl) phthalate) or PVC. This product is not made with natural rubber latex. The container is nontoxic and biologically inert. 

The container-emulsion unit is a closed system and is not dependent upon entry of external air during administration. 

The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
FIELD: medicinal biotechnology. SUBSTANCE: invention proposes the new strain of meningococci of serogroup C showing high and stable adhesive activity. Strain Neisseria meningitidis-141 is deposited in GISK Collection at number 194. Strain shows high adhesive activity and retains its at resowing. Adhesine obtained from this strain ensures to determine individual human erythrocyte sensitivity to adhesion of meningococci of the group C. EFFECT: enhanced effectiveness of adhesine. 2 tbl
PROBLEM TO BE SOLVED: To obtain a modified silk material having both properties of carbide and properties peculiar to silk and useful in various uses by heating undegummed silk, semi-degummed silk, degummed silk or a composite of them in the atmosphere of a gaseous stream at a prescribed gas pressure and a prescribed temp. based on air for a certain time to obtain the modified silk material having various colors. SOLUTION: Undegummed silk, semi-degummed silk, degummed silk or a composite of them is heated in the atmosphere of a gaseous stream at 0.5-1.5 atm gas pressure and 150-500 deg.C based on air for a certain time to obtain the objective modified silk material having various colors. Since the heating is carried out at a relatively low temp. range, the cost of consumed energy is reduced and the manufacturing method is industrially very advantageous. Since the heating is carried out in the gaseous stream at 0.5-1.5 atm gas pressure, the gaseous stream carries a volatile component formed by thermal decomposition to the outside of the system and a tar product is not produced. That is, the heating can be carried out without leaving impurities on the modified silk material.
Subjects will complete a supervised high-intensity interval training program for 12 weeks, including four weekly training sessions. The training session will include a 3 minute warm-up followed by six 40 second bouts of high intensity (85-95% of VO2peak) with 3 minutes moderate intensity (45-55% of VO2peak) between each bout of high intensity, concluding with a 3 minute cool-down. Each participant's target heart rate will be specific to them, calculated from the exercise test completed during Visit 1.
One kind of biomedical superparamagnetic nanoparticles and manufacture method thereof are provided in this patent claim. The manufacture method of superparamagnetic nanoparticles comprise following constituents: a suspension which includes calcium phosphate nanoparticles, and a metal ion solution which includes magnetic metal ions. Then, the suspension and the metal ion solution are well-mixed. The pH value of the mixture is adjusted to basic condition by adding an alkaline solution. Next, hot water bath is treated for a defined period of time followed by accompanying with the epitaxial growth of magnetic metal ions oh the surface of the calcium phosphate nanoparticles. Finally, collecting and separating calcium phosphate particles from the above solution, which contains magnetic metal crystalline. The calcium phosphate particles possessing magnetic metal crystalline on the surface have a superparamagnetic property and are with potential to be used in the biomedical fields.
PURPOSE:To obtain a garlic preparation, by freezing the bulb of barlic in liquid nitrogen, crushing and freeze-drying the bulb, and forming the obtained powder in the form of enteric preparation. CONSTITUTION:A garlic bulb is divided into individual segments by removing the skin of the bulb, and the segments are washed with water, dried in air, and immersed in liquid nitrogen. When the vigorous bubbling of the liquid nitrogen has ceased, the fragments are taken out of the liquid and pulverized without delay. The frozen powder is immediately freeze-dried in a vacuum drier under reduced pressure. The obtained dry powder is mixed with a diluent such as starch, lactose, microcrystalline cellulose, etc., granulated, added with a lubricant, tableted, and coated with an enteric coating to obtain a preparation free from garlic odor. As an alternative method, the granule or powder is filled together with the diluent in an enteric hard capsule. The content of the garlic powder is 500mg per tablet or capsule.
The orogastric will then be informed about the investigations of the premature babies to be removed. It will be held in a place where video recordings will be taken from the parent during the orogastric catheter insertion process. After informed consent is obtained, the group to be included will be determined by predetermined stratified randomization.

Standard treatment will be applied to all preterms. Standard approach; Wrapping data during painful and stressful interventions is an effective method to calm the data and shorten the spread (Gardner and Goldson, 2011). As shown by Erkut and Yıldız with 74 newborns, births wrapped during heel bleeding had lower pain scores and higher oxygen saturation temperatures than the control groups (Erkut and Yıldız, 2017). The wrapping application will be wrapped in the flexion and abduction positions of the pre-terms, as a subscription for all members, in a way that does not cause movement restriction.

Babies are cared for every morning between 08.00 and 08.30. During care, orogastric catheters, tubes, and probes are renewed. Hand, face, and body care and oral care are provided and diapers are changed. Orgastric catheters of the babies included in the study will be removed during care hours. Maintenance takes approximately 15 minutes. Wrapping will be applied as standard treatment to all babies included in the study. After the care was done, it was wrapped early and allowed to rest. They are fed at 09.00. Preterms to be included in the study in each group; 30-45 without insertion of orogastric tube. They will be wrapped up in their beds and will be in a rest period where they will not be disturbed until minutes before. Oragastric catheters will be removed before feeding at 9:00. Video recording will be made starting before the procedure of connecting to the oragastric catheter (2 minutes).
An antiseptic cleaning agent, generally, comprising chlorhexidine acetate and a solvent, such as an alcohol and/or water. The chlorhexidine acetate acts as a highly effective biocide. Additionally, the chlorhexidine acetate allows the cleaning agent to dry without leaving a tacky residue. Where the cleaning agent comprises one or more alcohols, the alcohols may comprise any suitable alcohols, including lower alcohols having from 1 to 6 carbon atoms, such as ethanol and isopropanol. In addition to chlorhexidine acetate, the cleaning agent optionally comprises another non-alcohol biocide, such as triclosan. The cleaning agent can be used in any suitable manner. For instance, the cleaning agent may be impregnated in an absorbent material, such as a towelette, swabstick, or gauze. Additionally, the absorbent material may comprise a positively charged or a non-ionic substance, such as polypropylene or polyester.
PROBLEM TO BE SOLVED: To obtain the subject promoter containing an extract of Coleus forskohlii having fat metabolism promoting action in fat cell and capable of effectively metabilizing and removing subcutaneous fat excessively accumulated by external coating by combinedly using a specific oil contact with the extract of Coleus forskohlii. SOLUTION: This promoter contains (A) an extract of Coleus forskohlii and (B) oil content selected from trigrlyceride (e.g. glyceryl triisostearate), a vegetable oil (e.g. olive oil) containing the compound, a monoterpene compound (e.g. eugenol), its derivative and a vegetable essential oil (e.g. eucalyptus oil) containing the monoterpene compound. The component A is preferably extracted by a method finely cutting dried or fresh underground part of Coleus forskohlii of the family Labiatae and immersing the dried or fresh underground part into a lower alcohol such as ethanol. When the promoter is compounded with a composition for external use, the components A and B are each compounded so as to become 0.5-5wt.% and 3-99wt.%, respectively. The composition for external use is preferably used in bathing, etc.
Morphine Sulfate Extended-release Capsules may cause severe hypotension including orthostatic hypotension and syncope in ambulatory patients. There is an increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g. phenothiazines or general anesthetics) . Monitor these patients for signs of hypotension after initiating or titrating the dose of Morphine Sulfate Extended-release Capsules. In patients with circulatory shock, Morphine Sulfate Extended-release Capsules may cause vasodilation that can further reduce cardiac output and blood pressure. Avoid the use of Morphine Sulfate Extended-release Capsules in patients with circulatory shock. [see ] Drug Interactions (7.2)
A total of 60 patients, in whom the placement of a crown in the posterior region of the maxilla or mandible was indicated, will be included in the study. The patients will be recruited from the Master of Buccofacial Prostheses and Occlusion (School of Dentistry; University Complutense of Madrid). Prior to treatment, patients will be informed regarding the aims of the study, the clinical procedure, the materials used, the risks and benefits of ceramic restorations and the alternatives to the proposed treatment. All the patients will be provided with a written informed consent for the inclusion in this study, Ninety posterior crowns will be produced and assigned in parallel and randomly to either resin-matrix ceramic, zirconia or metal-ceramic restorations. Three experienced prosthodontists will treat the patients. Abutment preparation will be performed in a standardized manner: circumferentially chamfer (1 mm in width), axial reduction of 1 mm, and an occlusal reduction of 1.5 to 2 mm. The tapering angle between the axial walls will be approximately 10- to 12- degrees. Full-arch digital impressions will be taken using an Intraoral Scanner. The restorations will be cemented with a resin cement. The restorations will be examined at one week (baseline), 1, 2, and 3 years, by two researchers who were not involved in the restorative treatment
Either the right or left leg of the participant(s) will be made transiently ischemic for 5 minutes following by 5 minutes of rest. This will be repeated for 4 times.
Cerebral ischemia-reperfusion (I/R) injury is a complex pathophysiological process involving multiple mechanisms, including apoptosis and autophagy, which can lead to significant neuronal damage. PIEZO1, a stretch-activated ion channel, has recently emerged as a potential regulator of cellular responses to ischemic conditions. However, its role in neuronal cell survival and death during ischemic events is not well elucidated. This study aimed to ascertain the regulatory function of PIEZO1 in neuronal cell apoptosis and autophagy in an in vitro model of hypoxia-reoxygenation and an in vivo model of brain I/R injury. HT22 hippocampal neuronal cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to simulate ischemic conditions, with subsequent reoxygenation. In vitro, PIEZO1 expression was silenced using small interfering RNA (si-RNA) transfection. The effects on cell viability, apoptosis, and autophagy were assessed using CCK-8 assays, PI-Annexin/V staining combined with flow cytometry, and Western blot analysis. Additionally, intracellular Ca2+ levels in HT22 cells were measured using a Ca2+ probe. The involvement of the AMPK-mTOR pathway was investigated using rapamycin. For in vivo validation, middle cerebral artery occlusion/reperfusion (MCAO/R) in rats was employed. To determine the neuroprotective role of PIEZO1 silencing, sh-PIEZO1 adeno-associated virus was stereotaxically injected into the cerebral ventricle, and neurological and histological outcomes were assessed using neurological scoring, TTC staining, H&E staining, Nissl staining, and immunofluorescence. In HT22 cells, OGD/R injury notably upregulated PIEZO1 expression and intracellular Ca2+ levels. Silencing PIEZO1 significantly diminished OGD/R-induced Ca2+ influx, apoptosis, and autophagy, as indicated by lower levels of pro-apoptotic and autophagy-related proteins and improved cell viability. Additionally, PIEZO1 modulated the AMPK-mTOR signaling pathway, an effect that was counteracted by rapamycin treatment, implying its regulatory role. In vivo, PIEZO1 silencing ameliorated brain I/R injury in MCAO/R rats, demonstrated by improved neurological function scores and reduced neuronal apoptosis and autophagy. However, these neuroprotective effects were reversed through rapamycin treatment. Our findings indicate that PIEZO1 is upregulated following ischemic injury and facilitates Ca2+ influx, apoptosis, and autophagy via the AMPK-mTOR pathway. Silencing PIEZO1 confers neuroprotection against I/R injury both in vitro and in vivo, highlighting its potential as a therapeutic target for stroke management.
The process comprises subjecting the tuberculoproteins (TP) to (a) a pptn. stage which is carried out in acid medium in the presence of a substance which is capable of rupturing H bonds, (b) a treatment stage in which the TP is treated with a modified cellulose contg. basic grps. and (c) a gel-filtration stage in which the TP is filtered on a gel formed from particles of defined porosity. Suitable H bond rupturing substances are urea, guanidine, formamide, thiourea, dimethyl sulphone or phenol, and suitable modified cellulases are ECTEOLA-, DEAE-, TEAE-, AEGE-, or PAB-cellulase. Highly pure, highly active TP with easily reproducible biological properties is obtd.
Juvenile Idiopathic Arthritis (JIA), the leading childhood rheumatic condition, has a chronic course in which persistent disease activity leads to long-term consequences. In the era of biologic therapy and tailored treatment, precise disease activity assessment and aggressive intervention for high disease activity are crucial for improved outcomes. As inflammation is a fundamental aspect of JIA, evaluating it reflects disease severity. Recently, there has been growing interest in investigating cellular immune inflammation indices such as the neutrophil-to-lymphocyte ratio (NLR) and systemic immune inflammation index (SII) as measures of disease severity. The aim of this retrospective study was to explore the potential of the SII in reflecting both inflammation and disease severity in children with JIA. The study comprised 74 JIA patients and 50 healthy controls. The results reveal a notable increase in median SII values corresponding to disease severity, exhibiting strong correlations with traditional inflammatory markers, including CRP and ESR (ρ = 0.714, ρ = 0.661), as well as the JADAS10 score (ρ = 0.690). Multiple regression analysis revealed the SII to be independently associated with JADAS10. Furthermore, the SII accurately distinguished patients with high disease activity from other severity groups (AUC = 0.827, sensitivity 81.5%, specificity 66%). These findings suggest that integrating the SII as an additional measure holds potential for assessing disease activity in JIA.
Custom-made insoles formed over an individual cast positive. 35 shore of hardness in material Ethyl Vinyl Acetate.
All patients were treated 3 times a week for 4 weeks. The treatment program of these patients included manual lymphatic drainage on the leg, skin care, bandaging and exercise.
Periodontitis, an inflammatory bone resorption disease associated with dental plaque, poses significant challenges for effective treatment. In this study, we developed Mino@ZIF-8 nanoparticles inspired by the periodontal microenvironment and the unique properties of zeolitic imidazolate framework 8, aiming to address the complex pathogenesis of periodontitis. Transcriptome analysis revealed the active engagement of Mino@ZIF-8 nanoparticles in innate and adaptive inflammatory host defense and cellular metabolic remodeling. Through sustained release of the anti-inflammatory and antibacterial agent minocycline hydrochloride (Mino) and the generation of Zn2+ with pro-antioxidant effects during degradation, Mino@ZIF-8 nanoparticles synergistically alleviate inflammation and oxidative damage. Notably, our study focuses on the pivotal role of zinc ions in mitochondrial oxidation protection. Under lipopolysaccharide (LPS) stimulation, periodontal ligament cells undergo a metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis, leading to reduced ATP production and increased reactive oxygen species levels. However, Zn2+ effectively rebalances the glycolysis-OXPHOS imbalance, restoring cellular bioenergetics, mitigating oxidative damage, rescuing impaired mitochondria, and suppressing inflammatory cytokine production through modulation of the AKT/GSK3β/NRF2 pathway. This research not only presents a promising approach for periodontitis treatment but also offers novel therapeutic opportunities for zinc-containing materials, providing valuable insights into the design of biomaterials targeting cellular energy metabolism regulation.
When the cervical dilation reached 4 cm, the peanut ball was first applied to the pregnant women in the side-lying position (right side/left side) for 20 minutes, and then the pregnant women were allowed to rest for 10 minutes. Second, the semi-seated position was applied for 20 minutes and the pregnant women were allowed to rest for 10 minutes. Third, the supine position was applied for 20 minutes followed by 10 minutes of rest. Fourth, the hand-knee position was applied for 20 minutes and rested for 10 minutes. Finally, the squatting position was practiced for 20 minutes and then the pregnant women rested for 10 minutes. Each position was practiced with the peanut ball for 20 minutes and rested for 10 minutes. Each position was performed once during the procedure. A pregnant woman who wished to remain in a position longer was allowed an additional 10 minutes without interrupting the flow of the intervention and then rested for 10 minutes.