anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Social working memory (WM) temporarily retains and manipulates various aspects of social information. Extensive research has highlighted impaired social cognitive functions in individuals with substance addiction. However, the specific deficit in social WM within this population remains notably understudied. Bridging this gap, we investigated social WM capacity using biological motion (BM) stimuli in methamphetamine (MA) abusers compared to an inmate control group, alongside contrasting these findings with their canonical WM deficits. Across two studies, we recruited female MA abusers (N = 80) undergoing post-isolation rehabilitation within a mandatory confinement circumstance. To ensure a pertinent comparison, we recruited female inmates (N = 80) subjected to comparable confinement. Results show substantial BM WM impairment in MA abusers, yet non-BM WM remains mostly intact. These findings highlight a pronounced social WM deficit in MA abusers, surpassing their canonical WM deficit relative to inmate controls. This suggests a distinct dissociation between social and canonical WM processing.
CF is a life-long illness that requires complex and dynamic adjustment by the patient and family. The nursing role is vital to the multidisciplinary team approach required in providing comprehensive, individualized care for these patients. Nurses facilitate the coordination of health care efforts and support the patient and family across physical and psychosocial domains. With the well-documented correlation between exercise tolerance and both survival and HRQoL, exercise represents a critical treatment focus for CF patients. Nurses contribute to standard exercise rehabilitation programs, through education, psychosocial support, and communication. In this exercise training study, the nursing role will include: a) teaching the patients and families how to use the OMNI scale, b) confirming that they understand the home-based exercise regimen, and c) ensuring that the home-care program is properly followed by placing weekly telephone calls to assess progress and barriers. Long-term nursing application will occur via dissemination of the OMNI training manual, to be developed as part of this study, for use by CF nurses in clinics worldwide.
Participants assigned to MANAGe-DM will receive the standard diabetes education mailing in addition to a novel nurse case management intervention. MANAGe-DM will include NCM services tailored to the health needs of Black men with recent release from incarceration and T2DM. MANAGe-DM will include three components: 1) diabetes education and skills training; 2) healthcare navigation and 3) basic needs navigation. . Each month of the study period, the NCM will conduct two phone call intervention sessions with individual participants.
Treatment of asymptomatic bacteriuria (ASB) is a common, but often unnecessary, practice. Our objective was to determine the impact of restrictive urinalysis reflex to culture (UARC) criteria on rate of urine cultures (UC) ordered and ASB treatment. Criteria were modified from positive leukocyte esterase, positive nitrites, or white blood cells (WBC) >10 cells to only WBC >10 cells. This pre-post study evaluated UARCs ordered in the emergency department or inpatient units. The primary outcome was the proportion of reflex UCs prevented. Secondary outcomes included the frequency of repeat UARCs and stand-alone UCs, gram-negative rod (GNR) bacteremia, and ASB treatment. In the pre-intervention, there were 4761 UARCs compared to 5420 in the post-intervention; 37.9 % and 21.4 % reflexed to UCs, a 43.5 % reduction in UCs. The rate of repeat UARCs, stand-alone UCs, and GNR bacteremia in the pre- and post-interventions were similar. ASB treatment rate was numerically lower in the post-intervention.
Based on findings from animal reproduction studies and the drug’s mechanism of action, BENDEKA can cause fetal harm when administered to a pregnant woman. Single intraperitoneal doses of bendamustine (that approximated the maximum recommended human dose based on body surface area) to pregnant mice and rats during organogenesis caused adverse developmental outcomes, including an increase in resorptions, skeletal and visceral malformations, and decreased fetal body weights. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use an effective method of contraception during treatment with BENDEKA and for 6 months after the last dose. Advise males with female partners of reproductive potential to use effective contraception during treatment with BENDEKA and for 3 months after the last dose. [see ( Use in Specific Populations 8.1, 8.3) and Clinical Pharmacology (12.1)]
An scFv peptide comprising a VH domain and a VL domain linked by an amino acid spacer is disclosed. The VH domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 64. The VL domain comprises a sequence with at least 80% sequence identity to the sequence of SEQ ID NO. 66. The scFv peptide also comprises the substitution or deletion of an amino acid in the VH domain at the position corresponding to C28.
The invention belongs to the field of traditional Chinese medicine, and relates to an Artemisia argyi Levl-containing traditional Chinese medicine preparation for treating chronic enteritis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from, by weight, 21-27 parts of Artemisia argyi Levl, 19-26 parts of Ficus microcarpa  Linn. f. leaves, 17-22 parts of all-grass of Rabdosia japonica(Burm.f.)Hara var.glaucocalyx(Maxim.)Hara[Plectranthus glaucocalyx Maxim.;Isodom glaucocalyx(Maxim.)Kudo], 15-21 parts of Antidesma bunius (L.) Spreng., 16-22 parts of fructus aurantii, 9-15 parts of Euryale ferox, 13-18 parts of fructus lycii, 12-16 parts of Fiveleaf Gynostemma Herb, 6-13 parts of Shepherdspurse herb, 10-16 parts of Myristica fragrans, 9-15 parts of fresh ginger and 5-13 parts of liquorice roots. The traditional Chinese medicine preparation has the functions of tonifying spleens, nourishing stomachs, resolving dampness, tonifying qi, eliminating dampness and helping digestion, and has a remarkable treatment effect on chronic enteritis. Clinical experiments show that no rebound phenomenon happens during the 6-month observation period of patients after the patients are cured. The traditional Chinese medicine is good in treatment effect, high in cure rate, free of toxic and side effects, high in clinical application value and capable of being used as a medicine for treating chronic enteritis.
This multicentre, retrospective medical record audit evaluated opioid analgesia prescribing within a Victorian metropolitan public hospital network. The study included all surgical patients discharged between January 2012 and December 2020 with one or more discharge prescriptions from three metropolitan hospitals (n = 117,989). The main outcome measures were mean oral morphine equivalent daily dose (OMEDD), mean number of opioid types and proportion of patients prescribed one or more slow-release opioids on discharge.Total opioid prescribing (mean OMEDD) peaked in 2013. Between 2017 and 2020 there was a trend towards prescribing fewer opioids on discharge. Over the study period, there was decreasing prescription of codeine and increasing prescription of oxycodone and tapentadol. The proportion of patients prescribed slow-release opioids increased in the earlier years of the study, reaching a peak of 20.6% in 2017. Since 2017 there has been a rapid reduction in the prescription of slow-release opioids.Subanalysis was undertaken to evaluate key changes in the opioid prescribing landscape in the health network. The removal of default opioid pack sizes in the electronic medication management system (December 2014) and the release of the Faculty of Pain Medicine-Australian and New Zealand College of Anaesthetists' statement regarding the use of opioid analgesics in patients with chronic non-cancer pain (March 2018) were associated with significant reductions in mean OMEDD prescribed on discharge (136 mg vs 122 mg and 120 mg vs 85.4 mg, respectively, P < 0.001).In conclusion, the quantity of opioids prescribed on discharge in this patient group peaked in 2013 and has been decreasing since.
A join request from a patient computing system identifies a patient, who is assigned to a waiting pool exposing each patient therein to a provider admitting computing system. An admission selection of the patient is received from the provider admitting computing system, and an audiovisual admissions teleconference between the patient computing system and the provider admitting computing system is initiated. A practitioner selection assignment from the provider admitting computing system assigns the patient to a provider practitioner, and in response, the patient is assigned to a provider practitioner pool associated with a provider practitioner computing system. The provider practitioner pool exposes each patient therein to the provider practitioner computing system. The audiovisual admissions teleconference is terminated. A first consultation selection of the patient from the first provider practitioner computing system initiates a first audiovisual consultation teleconference between the patient computing system and the provider practitioner computing system.
In recent years, there has been increased attention on the importance of healthcare environmental cleaning, including the need to professionalize and support the workforce responsible for performing cleaning. Global agendas and strategies on infection prevention and control (IPC) and water, sanitation and hygiene highlight the need for improvements to this sector, particularly in resource-limited healthcare facilities in low- and middle-income countries. Correspondingly, several resources have been developed that aim to (1) improve professional training of cleaners and (2) improve implementation of best practices in resource-limited settings. This commentary seeks to provide insight into the barriers and facilitators to implementing these resources, drawing on the practical experience from two initiatives across four countries from 2018 through 2023. Several common barriers were identified across the diverse settings, including (1) low empowerment and status of the workforce, (2) low pay, inadequate staff time for the high workload needed to achieve best practices and high turnover of staff, and (3) a lack of connection and integration of environmental cleaning with IPC and patient safety efforts at the participating hospitals. Despite barriers, local teams identified effective mitigation measures. While considerable time and effort will be needed to truly overcome these barriers, there are opportunities to build upon attention and momentum on this topic and IPC initiatives in resource-limited settings in low- and middle-income countries. We propose several broader actions, all of which require local leadership and context-specific approaches.
INTRODUCTION: Patients requiring emergent endotracheal intubation are at higher risk of post-intubation hypotension due to altered physiology in critical illness. Post-intubation hypotension increases mortality and hospital length of stay, however, the impact of vasopressors on its incidence and outcomes is not known. This scoping review identified studies reporting hemodynamic data in patients undergoing emergent intubation to provide a literature overview on post-intubation hypotension in cohorts that did and did not receive vasopressors.
METHODS: A systematic search of CINAHL, Cochrane, EMBASE and PubMed-Medline was performed from database inception until September 28, 2023. Two independent reviewers completed the title and abstract screen, full text review and data extraction per PRISMA guidelines. Studies including patients < 18 years or intubations during cardiac arrest were excluded. Primary outcome was the presence of hypotension within 30 min of emergent intubation. Secondary outcomes included mortality at 1 h and in-hospital.
RESULTS: The systematic search yielded 13,126 articles, with 61 selected for final inclusion. There were 24,547 patients with a mean age of 57.2 years and a slight male predominance (63.8%). Respiratory failure was the most common intubation indication. Across 18 studies reporting on vasopressor use prior to intubation, 1171/7085 patients received vasopressors pre-intubation. Post-intubation hypotension occurred in 22.2% of patients across all studies, and in 34.3% of patients in studies where vasopressor administration pre-intubation was specifically reported. One-hour mortality of patients across all studies and within the vasopressor use studies was 1.2% and 1.6%, respectively. In-hospital mortality across studies was 21.5%, and 13.1% in studies which reported on vasopressor use pre-intubation.
CONCLUSION: Patients requiring emergent intubation have a high rate of post-intubation hypotension and in-hospital mortality. While there is an intuitive rationale for the use of vasopressors during emergent intubation, current evidence is limited to support a definitive change in clinical practice at this time.
The invention discloses a liquid for treating arthralgia and a preparation method thereof, belonging to the technical field of deep processing of raw materials. The raw materials are subjected to primary extraction, so that the performance reduction and function loss of the raw materials caused by high-temperature cooking are avoided; the electronic activation principle is adopted to activate the basic stock solution of each raw material, so that the performance of the raw material is improved. The pain liquid after high pressure treatment can gradually generate heat energy at the affected part, realize transdermal treatment on the affected part, promote blood circulation and improve the absorption of effective components. Shortens the treatment time, achieves the quick curative effect and has excellent repairing function. The actual clinical application proves that only the diseased part generates heat after use, and the normal part does not generate heat. The pain liquid has no chemical components, is prepared by extracting pain liquid from pure plant Chinese medicinal materials, is harmless to human body, has no pollution to environment, and has simple production equipment. The pain liquid is formally produced, and the product has good practical application, quick curative effect and wide application range.
Adrenal insufficiency occurred in 0.3% of 2,230 patients taking abiraterone acetate and in 0.1% of 1,763 patients taking placebo in the combined data of the 5 randomized, placebo-controlled clinical studies. Adrenocortical insufficiency was reported in patients receiving abiraterone acetate in combination with prednisone, following interruption of daily steroids and/or with concurrent infection or stress.   
Monitor patients for symptoms and signs of adrenocortical insufficiency, particularly if patients are withdrawn from prednisone, have prednisone dose reductions, or experience unusual stress. Symptoms and signs of adrenocortical insufficiency may be masked by adverse reactions associated with mineralocorticoid excess seen in patients treated with abiraterone acetate. If clinically indicated, perform appropriate tests to confirm the diagnosis of adrenocortical insufficiency. Increased dosage of corticosteroids may be indicated before, during and after stressful situations [see Warnings and Precautions (5.1)].
PURPOSE:To provide a gel containing honey and a natural oil as main ingredients and capable of being safely used as a basic cosmetic, a drug for treating burns and external wounds, a health food, etc., by stably mixing the honey with the natural oil without adding a toxic preservative and an emulsifier. CONSTITUTION:A natural oil such as squalane oil, egg oil, olive oil, horse oil or sesame oil, honey and pure water are used in a volume ratio of <=4:>=1:>=1. The honey is dissolved in the pure water with stirring, and the mixture is mixed with the natural oil under vigorously vibration-stirring to form a gel layer as the upper layer and an aqueous solution layer as the lower layer. Both the layers are allowed to stand under vacuum, or air bubbles generated are deaerated by a centrifugal machine. The aqueous solution of the lower layer is dropwisely separated to leave only the gel layer. The gel layer is charged in a container to provide a gel containing the honey and the natural oil as main ingredients and capable of being safely used due to the synergistic effect of both the ingredients.
PURPOSE:To provide a perfumery composition containing a polyoxyalkylene alkyl glucoside, a nonionic surfactant and a perfumery component and easily removable from clothes even if attached to clothes as stains. CONSTITUTION:The objective composition is produced by compounding a polyoxyalkylene alkyl glucoside, a nonionic surfactant (e.g. polyoxyethylene monolaurate), a perfumery component and preferably further a lower alcohol (e.g. ethanol). The amounts of the polyoxyalkylene alkyl glucoside, the nonionic surfactant, the perfumery component and the lower alcohol are 0.5-50wt.%, 0.5-50wt.%, 1-30wt.% and 1-98wt.% based on the total weight, respectively. The nonionic surfactant is preferably the one having low odor and exhibiting liquid state at normal temperature. The perfumery component is a mixed perfumery produced by compounding animal or vegetable natural perfume or simple perfume.
Systems, methods, and devices for determining contexts and determining associated emotion profiles using information received from multiple emotion sensor enabled electronic devices, are disclosed. Contexts can be defined by a description of spatial and/or temporal components. Such contexts can be arbitrarily defined using semantically meaningful and absolute descriptions of times and locations. Emotion sensor data is associated with or includes context data that describes the circumstances under which the data was determined. The emotion sensor data can include emotion sensor readings that are implicit indications of an emotion for the context. The sensor data can also include user reported data with explicit descriptors of an emotion for the context. The emotion sensor data can be filtered by context data according a selected context. The filtered sensor data can then be analyzed to determine an emotion profile for the context that can be output to one or more users or entities.
The invention discloses an externally applied liniment for treating premature ejaculation. The externally applied liniment is characterized by comprising the following raw medicines in parts by weight: 13-17 parts of cnidium, 26-34 parts of asarum, 26-34 parts of cloves, and 102-134 parts of 95% ethanol. The externally applied liniment is prepared by adding the cnidium, the asarum and the cloves to the ethanol, soaking for 10 days to take a solution, thus the externally applied liniment is obtained. The externally applied liniment has the following advantages that the Chinese medicinal herbs are soaked by the ethanol, so that effective components eugenol, methyl eugenol and osthole in the Chinese medicinal herbs are fully dissolved in the ethanol to improve the utilization ratio of the medicament, and a leaching solution of the three Chinese medicinal herbs is combined to prolong the ejaculation time, so as to effectively treat the premature ejaculation. The externally applied liniment is prepared from the pure Chinese medicinal herbs, and takes the ethanol as a solvent, and therefore the externally applied liniment has no toxic and side effects for patients even after a long-term use, and is high in safety performance. The externally applied liniment is simple in production method and suitable for mass production and promotion.
PURPOSE:To increase the permeability and wettability of a lipid compsn. as well as the safety by blending lysophosphatidylcholine with monoglyceride of unsatd. fatty acid having a specified number of carbon and fatty acid to prepare the lipid compsn. CONSTITUTION:Lysophosphatidylchloline (A) is blended with monoglyceride (B) of 16-22C unsatd. fatty acid and 9-13C fatty acid (C) as essential components to prepare a lipid compsn. The weight ratios among the components A-C are B/A=10/90-90/10, C/B=20/100-200/100 and C/(A+B)=10/100-200/100. In case of (B+C)/A>5, bile acids and/or alkali salts of bile acids are added by 5-100wt.% of the total amt. of the components A-C. The lipid compsn. has very high safety and superior surface activity.
Premedication: IM Midazolam 0.05-0.07mg/kg. Anesthesia induction: Midazolam 0.03mg/kg, Propofol 2-3mg/kg, Fentanyl 1-2mcg/kg and Cisatracurium 0.2mg/kg or alternatively Rocuronium 0.6-1.2mg/ kg. Anesthesia maintenance: Desflurane set at approximately 1 MAC, Morphine 0.1-0.12mg/kg, Fentanyl 1-2mcg/kg during induction and 50-100mcg prn, Paracetamol 1g +/- Dexketoprofen trometamol 50mg, along with Ondansetron 4mg or Droperidol 0.625mg. Wound infiltration: Ropivacaine 75-150mg. Surgical ward: PCA pump with Morphine for the first 3 postoperative days. Additional postoperative analgesia: Paracetamol 1g 1x3 +/- Dexketoprofen trometamol 50mg 1x2. Rescue therapy only: Tramadol 50-100mg.
Kinesio taping will be applied with muscle inhibition technique by stretching from the origin to the insertion of the upper trapezius, cervical thoracic and lumbar paravertebral muscles. Sham neural therapy will be applied to the bilateral arms of the patients. Home exercise program; trapezius stretching, cervical, thoracic and lumbar paravertebral muscle stretching exercises will be required to be performed 10 times and every day.
PROBLEM TO BE SOLVED: To obtain an eye drop useful as e.g. a therapeutic agent for neuroretinal degenerative diseases by including a specific amide compound. SOLUTION: This eye drop contains a compound of formula I [Ar is a (substituted) phenyl or (substituted) aromatic heterocyclic group; n is 0-2; R1 is H, a (substituted) alkyl or alkenyl or the like; R2 and R3 are each a (substituted) alkyl, or two or three of R1 to R3 are mutually bound to form a ring together with the carbon atom to which they are bound; R4 and R5 are each H or a (substituted) alkyl; R6 is H, OH or an alkyl] (e.g. N-t-butyl-2,4- difluorobenzamide). The compound of formula I is obtained, for example, by reaction between a compound of formula II and a compound of formula III (R10 is H, or a protected OH or alkyl). This eye drop is administered at 1-2 droplets at a time normally once to six times a day; in the case of a form of eye ointment, an appropriate amount thereof is applied onto the conjunctival sac normally once to twice a day.
1483816 Filler composition; dental cements LEE PHARMACEUTICALS 27 Sept 1974 [28 Sept 1973] 42176/74 Heading C3P An X-ray opaque filler composition for synthetic resin compositions comprises 5-35% by weight of the filler of X-ray opaque particulate barium glass having a refractive index of 1À7- 2-0 and 95-65% by weight of the filler of an X-ray transparent particulate filler material having a refractive index within the range known for synthetic resins. The filler material may be silica, quartz, glass, e,g. borosilicate glass, or micro fibrous refractory salts. The particle size of the filler composition may be 0À5-50 microns with the average particle size being 2-15 microns. A suitable refractive index for the filler material is 1À4 to 1À6. The filler composition may constitute 90-40% by weight of a composition useful as a dental restorative composition comprising in addition a polymerizable monomer. The polymerizable monomer may be a mixture of the diglycidyl ether of bisphenol-A dimethacrylate and triethyleneglycol dimethacrylate, which is polymerized with the aid of a catalyst comprising benzoyl peroxide and N,N-bis-(2-hydroxyethyl)toluidine and specific filler compositions in the examples comprise barium glass and one of borosilicate glass, amorphous silica and quartz.