anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a teabag for treating the acute and chronic pharyngolaryngitis, and belongs to a healthcare beverage. Results of clinic experiment treatment for several tens of years show that the effective rate of the teabag to various types of acute and chronic pharyngolaryngitis patients is 98%, the cure rate is above 92%, and the curative effect is substantial. A formula of the teabag comprises 5-10 parts of chrysanthemum, 3-5 parts of lily, 2-6 parts of Exocarpium Citri Rubrum, 3-10 parts of Rhizoma Polygonati Odorati, 2-8 parts of orange peel, 2-5 parts of Cichorium intybus, 3-6 parts of mulberry leaf, 3-5 parts of almond, 3-6 parts of Lophatherum gracile, 3-6 parts of Fructus Gardeniae, 5-10 parts of Chinese olive, 3-10 parts of Radix Platycodonis, 3-6 parts of Corsvenor Momordica Fruit, 3-10 parts of honeysuckle flower, 5-10 parts of Lycium Chinense, 3-10 parts of Sterculia lychnophora, 3-5 parts of mint and 2-5 parts of licorice root. All medicines in the formula are foods of the medicine food homology, have no toxic side effects and can be easily accepted by the patients because the dietotherapy idea can be easily accepted by the patients. The teabag can be immersed like a tea when the patients drink, and medicinal components can be directly absorbed by abundant capillary vessels of sublingual mucous membranes to directly reach the positions of the patients. The teabag is convenient to carry, is beneficial to all ages and is suitable for four seasons.
The invention overcomes the defects of a chemical hair-care shampoo, ecological pure natural plants are used as raw materials, and natural hair care shampoo for preventing dry hair and nourishing hair is produced. The natural plant components are extracted by high technology, the shampoo has the characteristic of extremely small molecules, the shampoo can rapidly penetrate into scalp and hair to hair follicle and the deep of hair cores after being applied to scalp and hair, and the efficacies can be timely performed. Eclipta prostrate is fresh Eclipta prostrate on Bayan Har Mountains, and is not polluted by any chemical substances. Fresh stems and leaves of Eclipta prostrate are selected and harvested, and picked by hands totally. Traditional squeezing modes are used for extracting primary normal juice of Eclipta prostrate, in order to guarantee fresh and effective components of Eclipta prostrate. Because of particularity of plant molecules, the plant molecules do not like chemical elements which produce harmful substances by chemical combination, oxidation and other mixing reactions, and the plant molecules can exist together and perform different efficacies. The hair-care shampoo product which employs pure plant as a core is made of natural plants, accords with nature of human bodies, conforms pH-value of human bodies, and has few differences, so that the product is better adapted to human bodies, and can better avoid generation of allergy.
BACKGROUND: Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims to investigate the effects of WSB1 on myocardial ischemia-reperfusion (IR) injury.
METHODS: The myocardial IR was induced by left anterior descending (LAD) ligation for 45 min and subsequent reperfusion. The overexpression of WSB1 was mediated by tail vein injection of AAV9 loaded with WSB1 encoding sequence two weeks before IR surgery. H9c2 myocardial cells underwent oxygen-sugar deprivation/reperfusion (OGD/R) to mimic IR, and transfected with WSB1 overexpression or silencing plasmid to alter the expression of WSB1.
RESULTS: WSB1 was found highly expressed in penumbra of myocardial IR rats, and the WSB1 overexpression relieved IR-induced cardio dysfunction, myocardial infarct and pathological damage, and cardiomyocyte death in penumbra. The ectopic expression of WSB1 in H9c2 myocardial cells mitigated OGD/R-caused apoptosis, and silencing of WSB1 exacerbated the apoptosis. In addition, WSB1 activated β-catenin signaling, which was deactivated under the ischemic condition. The co-immunoprecipitation results revealed that WSB1 mediated ubiquitination and degradation of glycogen synthase kinase 3 beta (GSK3β) as an E3 ligase in myocardial cells. The effects of WSB1 on myocardial cells under ischemic conditions were abolished by an inhibitor of β-catenin signaling.
CONCLUSION: WSB1 activated β-catenin pathway by promoting the ubiquitination of GSK3β, and restrained IR-induced myocardial injury. These findings might provide novel insights for clinical treatment of myocardial ischemic patients.
In Guinea-Bissau, a combined OPV and VAS campaign took place in November 2002. Given the uncertainty about the best dose of VAS, we examined whether the half dose compared with the full dose currently recommended by WHO gave an equally good protection against childhood morbidity and mortality. Mortality after supplementation was lower, though not significantly so, for children who had received the half dose. However, there was a highly significant inversion of the effect for boys and girls; while the low dose was clearly better for girls, the full dose might have been slightly better for boys. The girls' responses to the high versus the low dose of vitamin A might have depended on the last vaccine received before the OPV and VAS campaign.

We believe that these findings call for confirmation. In connection with the OPV and VAS campaign in November 2004 in Guinea-Bissau, we intend to examined whether half the dose of the dose currently recommended by WHO as compared to the full dose has a more beneficial effect on mortality and morbidity in girls, and furthermore address the potential effect modification by the last vaccine received before the supplementation.
Participants included in the experimental arm will be adults aged 18 years and older with chronic/recurrent neck pain Grade II who have been prescribed cervical manipulation for treatment of their condition. Each participant will undergo three separate test maneuvers consistent with prior work completed at the St. Joseph's Healthcare Hamilton Brain Body Institute. Each participant will begin with neutral cervical spine as a standard natural control, followed by block randomization between maximum voluntary rotation of the cervical spine and one cervical manipulation. Please see Intervention section for a detailed description.
Patients undergo bone marrow biopsy using the traditional Jamshidi needle. Patients complete questionnaires at baseline, 30 minutes after biopsy, and on days 1, 3, and 7.
Microstrip crescent antennas offer compactness, conformability, low profile, high sensitivity, multi-band operability, cost-effectiveness and ease of fabrication in contrast to bulky, rigid horn, helical and Vivaldi antennas. This work presents crescent sensors for monitoring brain pathology associated with stroke and atrophy. Single- and multi-element crescent sensors are designed and validated by software simulations. The fabricated sensors are integrated with glasses and experimentally evaluated using a realistic brain phantom. The performance of the sensors is compared in terms of peak gain, directivity, radiation performance, flexibility and detection capability. The crescent sensors can detect the pathologies through the monitoring of backscattered electromagnetic signals that are triggered by dielectric variations in the affected tissues. The proposed sensors can effectively detect stroke and brain atrophy targets with a volume of 25 mm3 and 56 mm3, respectively. The safety of the sensors is examined through the evaluation of Specific Absorption Rate (peak SAR < 1.25 W/Kg, 100 mW), temperature increase within brain tissues (max: 0.155 °C, min: 0.115 °C) and electric field analysis. The results suggest that the crescent sensors can provide a flexible, portable and non-invasive solution to monitor degenerative brain pathology.
The coexistence of hypertension and atrial fibrillation (AF) is common and accounts for a worse prognosis. Uncertainties exist regarding blood pressure (BP) measurements in AF patients by automated oscillometric devices. The Microlife WatchBP 03 AFIB ambulatory BP monitoring (ABPM) device including an AF algorithm with each measurement was used in 430 subjects aged >65 years referred for ABPM and with assumed paroxysmal AF to perform intra-individual comparisons of BP during both AF-indicated and sinus rhythm. Only subjects with >30% of measurements indicating AF and episodes >30 min for assumed AF and for sinus rhythm were included. Mean age was 78 ± 7 years, 43% were male, 77% hypertensive, and 72% were treated. Compared to sinus rhythm, 24-h mean arterial pressure was similar (87.2 ± 9.5 vs 87.5 ± 10.6 mm Hg, p = 0.47), whereas 24-h systolic BP tended to be lower (123.6 ± 13.9 vs 124.7 ± 16.1 mm Hg, p = 0.05) and night-time diastolic BP higher (64.6 ± 10.9 vs 63.3 ± 10.4 mm Hg, p = 0.01) in assumed AF. Diastolic (not systolic) BP variability was higher in AF (p < 0.001). Results were similar with heart rates <90 and ≥90 bpm. In conclusion, this is the first study to use intra-individual comparisons of averaged BP during an ABPM in assumed paroxysmal AF and sinus rhythm. Our results imply that ABPM is feasible and informative also in patients with AF. We also suggest that an AF detection algorithm offers a new approach to evaluate the reliability of averaged BP values in AF compared to SR during an ABPM.
Research on the relationship between obstructive sleep apnea and cognitive functioning has yielded conflicting results, particularly in the older population, and moderators of this association have rarely been studied. Here we investigated the cross-sectional association between obstructive sleep apnea and cognitive functioning as well as the moderating effect of age, sex, apolipoprotein E4, and obesity on this association among community-dwelling older people. We analysed data from 496 participants (71.4 ± 4.4 years; 45.6% men) of the HypnoLaus study who underwent polysomnography and a battery of neuropsychological tests. The sample was categorised as no-to-mild obstructive sleep apnea (apnea-hypopnea index 0-14.9/h; reference), moderate obstructive sleep apnea (apnea-hypopnea index 15.0-29.9/h), or severe obstructive sleep apnea (apnea-hypopnea index ≥30/h). Regression and moderation analyses were performed with adjustment for confounders. Apolipoprotein E4 and obesity moderated the association between severe obstructive sleep apnea and processing speed, whereas no moderating effects were found for age and sex. In apolipoprotein E4 carriers only, severe obstructive sleep apnea was associated with lower performance in Stroop condition 1 (B = 3.13, p = 0.024). In obese participants only, severe obstructive sleep apnea was associated with lower performance in Stroop condition 1 (B = 3.02, p = 0.025) and Stroop condition 2 (B = 3.30, p = 0.034). Severe obstructive sleep apnea was also associated with lower executive function in the whole sample according to Stroop condition 3 (B = 3.44, p = 0.020) and Stroop interference score (B = 0.24, p = 0.006). Our findings support associations of severe obstructive sleep apnea (but not moderate obstructive sleep apnea) with lower performance in processing speed and executive function in the older general population. Apolipoprotein E4 and obesity appear to be vulnerability factors that strengthen the association between severe obstructive sleep apnea and lower performance in processing speed.
PURPOSE: A two-layer cosmetic composition with falling cohered pearl powder lumps, and a manufacturing method thereof are provided to maintain the moisture in skin, and to supply gloss and pearl-like feeling by being used as facial pearl-mist and body pearl-mist. CONSTITUTION: A cosmetic composition provides a dynamic visual effect of falling snow by being separated into two layers when placing after shaking. The two-layer cosmetic composition comprises 5-60 weight% of ethanol, 0.01-20 weight% of pearl powder, and the residual weight% of silicone oil. The powder has a particle size of 0.001-0.30mm. The pearl powder is more than one or two kinds selected aluminum powder, mica, titanium dioxide, iron oxide, polyethylene terephthalate, silica, alumina, polyester, and acrylate copolymers. The two-layer cosmetic composition comprises the following steps: screening after pulverizing pearl powder to have a particle size of 0.001-0.3mm; manufacturing a mixed solution by adding 0.01-20 weight% of pearl powder and the residual amount of silicone oil to 5-60 weight% of ethanol; inducing layer-separation by settling the mixed solution for 10-20 minutes after stirring; and controlling the separation rate to maintain the layer-separation rate at 10 seconds to 2 minutes while adding 0.001-10 parts by weight of distilled water to the mixed water after shaking the mixed solution.
To analyze the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) permeability parameters and serum vascular endothelial growth factor (VEGF) levels in a rabbit VX2 liver cancer model with insufficient microwave ablation (MWA), to observe the dynamic changes in residual tumor angiogenesis in the short term after MWA, and to assess the effectiveness of donafenib as adjuvant therapy. Forty rabbits with VX2 liver tumors were randomly divided into three groups: an insufficient MWA group (n = 15), a combined treatment group (n = 15) and a control group (n = 10). The dynamic changes in VEGF expression after MWA and the effectiveness of donafenib as adjuvant therapy were evaluated by DCE-MRI and serum VEGF levels before surgery and 1, 3, 7, and 14 days after surgery. The correlation between the volume translate constant (Ktrans) of DCE-MRI parameters and serum VEGF levels fluctuated after ablation, but the coefficient was always positive (all p < 0.001). Repeated-measures ANOVA revealed significant changes in the serum VEGF concentration (F = 40.905, p < 0.001; partial η2 = 0.689), Ktrans (F = 13.388, p < 0.001; partial η2 = 0.420), and tumor diameter in each group (F = 34.065, p < 0.001; partial η2 = 0.648) at all five time points. Pairwise comparisons showed that the serum VEGF level, Ktrans value and tumor diameter in the insufficient MWA group and combined treatment group were significantly lower at 1 d than in the control group, but these values gradually increased over time (all p < 0.05). Ktrans and tumor diameter were significantly greater in the insufficient MWA group than in the control group at 14 days (all p < 0.05). The serum VEGF concentration, Ktrans, and tumor diameter were significantly lower in the combined treatment group than in the other two groups at 3, 7, and 14 days (all p < 0.05). Ktrans is positively correlated with the serum VEGF concentration. Ktrans and the serum VEGF concentration changed significantly after treatment with insufficient ablation or in combination with donafenib, and Ktrans may change faster. Insufficient MWA promotes the progression of residual tumors. Adjuvant treatment with donafenib is effective.
Period 1: 500 mg (for body weight \<60 kg); 750 mg (for body weight 60-100 kg); and 1000 mg (for body weight \>100 kg) IV infusion at Baseline, Week 2, Week 4, Week 8, Week 12, Week 16 and Week 20. Period 2: open label upadacitinib 15 mg QD for 192 weeks.
PROBLEM TO BE SOLVED: To provide a detergent composition having viscosity without using a thickener, being excellent in foaming and foam quality (creamy property) when using, a feeling of use without the hair friction feeling or a stickiness when rinsing, and low temperature stability.SOLUTION: The invention provides a detergent composition containing the following components (A)-(F), and the compounding ratio (B)/(D) is 1-5.5, and the compounded amount (B)+(D) is 20-45 mass% of all the compositions. (A) is one or more kinds selected from N-acylamino acid salt consisting of a fatty acid residue having an acyl group of carbon atom number 8-22, and an amino acid having an IOB value of 3 or more, or two carboxyl groups. (B) is 10-42 mass% of a fatty acid salt. (C) is a cation property polymer. (D) is 3-22.5 mass% of alkylpolyglucoside. (E) is 0-1.5 mass% of sodium chloride. (F) is 0-2 mass% of potassium chloride.
A long lasting breath mint including a carrier and a flavorant, wherein the carrier includes at least one of a high viscosity cellulose ether and a low viscosity cellulose either and an alginate. The carrier forms a gel upon contact with saliva. A tablet is placed in the mouth of user, whereupon the tablet is wetted with saliva. A surface of the tablet is converted to a gel resulting in a tablet having an outer gel layer and a core. The gel serves as an adhesive for adhering the tablet to mouth structure. The gel slows exposure of the core to moisture and also slows diffusion of flavorant into the mouth of the user with the gel resulting in a breath mint having an extremely long life prior to complete dissolution, e.g., greater than 30 minutes or longer.
The invention provides an interferon with the freeze dry spray formulation and the preparation process thereof. The solute and dissolvent are kept separately. It has simple prescription and stable activity. The freeze dried interferon spray can be used by spraying and dripping to noses. The sprayed micro particles can be absorbed directly through throat, nose and lung. The dosage is small and the effect taking time is short. It can be used for prevention and treatment of influenza, SARS and other virus infection diseases.
This study will involve asking fifty children coming to the hospital for their standard of care procedure to treat a separate cardiac condition to participate. Patients approached will already have an intravenous line in place for their procedure. After consent and assent as necessary are obtained, the patient be brought to a separate room for the low-dose epinephrine infusion trial. The patient will lie down on a table, be hooked up to an EKG machine and the infusion will start. The amount of epinephrine actually infused is based on the weight of the patient but is substantially less than the dose received from an epinephrine auto-injection for anaphylaxis. After about 40 minutes, the trial will be completed and the patient may return to the waiting room for their original procedure. We have performed this test on a number of pediatric patients suspected of having LQTS with promising results and with little to no side effects. The patient will be awake for the procedure and will be able to verbalize concerns or complaints. A pediatric electrophysiologist and nurse will be present throughout the entire procedure.

The purpose of this study is to determine if children who are infused with low amounts of epinephrine will also maintain their normal QT interval as it does with healthy adults. This study would hope to prove that low-dose epinephrine infusion trials can serve as a way of identifying children with LQTS so that they may be effectively treated and potentially have their lives saved.
The invention discloses imatinib mesylate tablet cores comprising, by weight, 20-70% of imatinib mesylate alpha crystalline form, 10-50% of a filling agent, 0-10% of an adhesive, 10-30% of a disintegrant, 0.1-5% of a flow aid, and 0.1-2% of a lubricant. According to the tablet core preparation method, granulation and tabletting are carried out with the formula. The invention also discloses imatinib mesylate coated tablets and a preparation method thereof. The coated tablets comprise, by weight, 95-97% of the imatinib mesylate tablet cores, 0.5-4% of a film forming agent, 0.1-1% of a plasticizer, 0.1-1% of a coloring agent, and 0.1-1% of a lubricant. The preparation method of the coated tablets comprises the steps that the tablet cores are coated, such that the imatinib mesylate coated tablets are prepared. The tablets have the advantages of high dissolution rate and fast release.
A Yang restoring open fire moxibustion rod is made of the following drug materials of: Pinellia integrifolia N.E. Brown, Sanbaibang, trillium tschonoskii maxim., trident maple, Herba Chloranthi Serrati, Kadsura Pepper Stem, pangolin, aleppo dock rhizome, Polygonum amplexicaule var. sinense, musk, borneol, ardisia crenata, cortex acanthopanacis, Coniogramme intermedia Hieron., Rohdea japonica, monkshood, Aconitum kusnezoffii, Pinellia ternata and Arisaema consanguineum Schott. A manufacturing process of the Yang restoring open fire moxibustion rod comprises the following steps of: uniformly mixing the above drugs; extracting traditional Chinese drugs by the ethanol extraction technology; extracting the above drugs to enhance the active ingredients of the drugs; processing the extracted drugs into particles, and preparing into the usable Yang restoring open fire moxibustion rod by a machine. The Yang restoring open fire moxibustion rod avoids disadvantages of traditional mugwort and has no uncomfortable smell as well as smoke. The preparation of the Yang restoring open fire moxibustion rod is simple to operate and saves time. In addition, acupuncture points are not restricted, acupoints which can be stabbed by needles can all undergo moxibustion, and some taboo acupoints, which can not be stabbed, such as Shenque (CV 8), Ruzhong (S17) and the like, can undergo moxibustion safely. The moixbustion rod is convenient to use, has no toxic and side effect, can enlarge the treatment range and has a popularization value.
Patients receive nivolumab IV over 1 hour and relatlimab IV over 1 hour on days 1 and 29. Patients then undergo surgery on day 57. After surgery, patients receive nivolumab IV over 1 hour and relatlimab IV over 1 hour every 4 weeks for 10 doses in the absence of disease progression or unacceptable toxicity.
Moderate and severe obstructive sleep apnea (OSA) is strongly associated with cardiovascular diseases, diabetes and also with occupational and traffic accidents due to fatigue and daytime sleepiness. Treatment of moderate OSA is usually by a mandibular advancement device (MAD) and in sometimes even Continuous Positive Airway Pressure (CPAP). MAD and CPAP treatment effectiveness is impeded by limited compliance with long term treatment. Knowledge about mechanical barriers in upper respiratory tract has triggered interest in finding a new treatment method that may prevent collapse of airways during sleep. The investigators believe that stabilization of the neck by using a cervical collar (CC) during sleep helps sustain airway patency. This would mean improved oxygen saturation in the blood and a reduction of daytime fatigue in patients with OSA.
<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin having a smooth feeling of use, exhibiting excellent beauty culture effects and having good stability with time even when one or two or more kinds selected from a particulate water-soluble ascorbic acid and its derivative and a salt thereof are formulated.  <P>SOLUTION: The external preparation for skin is characterized as comprising the one or two or more kinds selected from the fine particulate water-soluble ascorbic acid and its derivative and the salt thereof. One or two or more kinds selected from ascorbic acid phosphate magnesium salt and ascorbic acid phosphate sodium salt are preferably used as the one or two or more kinds selected from the fine particulate water-soluble ascorbic acid and its derivative and the salt thereof. The fine particulate ascorbic acid derivative is converted into a suspension in which the fine particulate ascorbic acid derivative is dispersed in an oily medium and finely particulated. The resultant fine particles are formulated in the external preparation for skin.  <P>COPYRIGHT: (C)2005,JPO&NCIPI