anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Transcranial magneto-acoustic stimulation (TMAS), which is characterized by high spatiotemporal resolution and high penetrability, is a non-invasive neuromodulation technology based on the magnetic-acoustic coupling effect. To reveal the effects of TMAS treatment on amyloid-beta (Aβ) plaque and synaptic plasticity in Alzheimer's disease, we conducted a comparative analysis of TMAS and transcranial ultrasound stimulation (TUS) based on acoustic effects in 5xFAD mice and BV2 microglia cells. We found that the TMAS-TUS treatment effectively reduced amyloid plaque loads and plaque-associated neurotoxicity. Additionally, TMAS-TUS treatment ameliorated impairments in long-term memory formation and long-term potentiation. Moreover, TMAS-TUS treatment stimulated microglial proliferation and migration while enhancing the phagocytosis and clearance of Aβ. In 5xFAD mice with induced microglial exhaustion, TMAS-TUS treatment-mediated Aβ plaque reduction, synaptic rehabilitation improvement, and the increase in phospho-AKT levels were diminished. Overall, our study highlights that stimulation of hippocampal microglia by TMAS treatment can induce anti-cognitive impairment effects via PI3K-AKT signaling, providing hope for the development of new strategies for an adjuvant therapy for Alzheimer's disease.
PURPOSE: To compare the outcome of indirect inguinal hernias repaired by using single-port laparoscopic percutaneous internal ring suture (SPIRS) between the pediatric and adult females.
METHODS: The medical records of females who were clinically assessed to have inguinal hernia from Oct. 2016 to May 2022 were reviewed. Patients who received laparoscopy for the diagnosis of the hernia type and customized treatment according to their hernia type were included, while those who chose other operation methods initially were excluded. The patients were divided into the adult and pediatric groups based on their age. The demographic characteristics, hernia types, operation durations, and outcomes were analyzed between these two groups.
RESULTS: A total of 65 adults and 60 children were included in this study. The median age was 38 years. (range: 23-88) for group A and 3 years (range: 0.1-16) for group P. Indirect hernias were present in 85% of adults and 100% of children. All the indirect hernias were repaired by SPIRS uneventfully. Incidence of contralateral patent processus vaginalis was 24% in adults and 50% in children (p = 0.016). The average operation time was 22/46 min (one/two sides) for the adults and 9/15 min (one/two sides) for the pediatrics (p < 0.010 for both). The overall complication rates were 5.4% and 3.3% for the adult and pediatric group respectively (p = 0.106). No recurrence was observed in the pediatric group, but two adults experienced recurrence and another had chronic postoperative inguinal pain, necessitating reoperation. The mean follow-up period was 38.6 ± 15.4 months for adults and 42.8 ± 18.9 months for children (p = 0.198).
CONCLUSION: Our results support that the pathogenesis of indirect inguinal hernia for the female adults is due to the non-obliteration of a congenital processus vaginalis. Tailored treatment of the female IIH by using single-port laparoscopic percutaneous internal ring suture may be an alternative for the management of female IHs.
Sixty percent of cases of non-valvular AF are associated with other modifiable risk factors, including: obesity, diabetes, hypertension, or sleep apnea. Treating modifiable risk factors has been shown to improve morbidity and mortality in patients with AF. Treatment of AF with antiarrhythmic drugs or catheter ablation has not been shown to improve survival. Recently, small cohort studies combining exercise, diet, and antiarrhythmic medications and/or ablation have shown improvements in cardiovascular risk factors and reduction in AF symptoms and frequency.

The aim of this study is to demonstrate a reduction in frequency and symptoms of AF and improvements in cardiovascular risk factors following a lifestyle intervention in patients with paroxysmal AF. This study uses a reproducible intensive supervised cardiac rehabilitation that includes exercise, diet, and risk factor modification for patients with paroxysmal, non-valvular AF. The investigators expect that a lifestyle intervention will show significant improvement in fitness and weight loss and improvements in AF symptoms and frequency, and cardiovascular risk factors when compared to a control group with paroxysmal AF and similar baseline characteristics who do not receive a diet and exercise program.
This study was planned as a randomized controlled trial to investigate the effect of fascial distortion model on pain severity, cervical posture and joint position sense in patients with tension headache. Individuals with tension-type headache will be divided into control (n=15) and study group (n=15) by simple random method. Fascial distortion modeling will be applied to the study group for a total of 4 weeks, one session a week for 30 minutes. No application was made to the control group. Evaluations will made for all individuals twice, at baseline and after 4 weeks. Pain severity of individuals was evaluated with VAS and McGill-Melzack Pain Scale, cervical posture with Posturescreen Mobile application, joint position sense with laser cursor-assisted angle repetition test.
The invention belongs to the field of medicinal preparations, and discloses quetiapine fumarate sustained-release tablets and a preparation method thereof. The sustained-release tablets are mainly prepared from the following raw materials in part by mass: 1 part of quetiapine fumarate (based on quetiapine), 0.1 to 1 part of acrylic resin framework material, 0 to 0.5 part of filling agent, 0.04 to 0.05 part of adhesive and 0.01 to 0.02 part of lubricating agent. The sustained-release tablets can comprise hydrophilic gel framework material for adjusting the release rate of the main medicament, and the mass ratio of the quetiapine to the hydrophilic gel framework material is 1: (0.1-0.5). The prepared quetiapine fumarate sustained-release tablets can be used for treating schizophrenia. The sustained-release tablets have the advantages of reducing the administration frequency, improving the administration compliance of a patient, improving the medicinal effect, ensuring application safety and the like, and are more suitable for patients. Meanwhile, the preparation method of the sustained-release tablets is simple and favorable for industrialized large-scale production.
The invention relates to imidazolidine derivatives of formula (I), in which B, E, W, Y, R, R?2, R3, R30¿, e and h have the meanings cited in the claims. The compounds of formula (I) are valuable medicament active agents which are suited, for example, for treating and preventing inflammatory diseases, for example, rheumatoid arthritis, or allergic disorders. The compounds of formula (I) are inhibitors of adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 which belong to the group of integrins. They are generally suited for treating or preventing diseases which are caused by an undesirable degree of leukocyte adhesion and/or leukocyte migration or are connected therewith or with which cell-cell interactions or cell-matrix interactions play a roll. Said interactions are based on interactions of VLA-4 receptors with the ligands thereof. The invention also relates to a method for producing the compounds of formula (I), to the use thereof, especially as medicament active agents, and to pharmaceutical preparations which contain compounds of formula (I).
Subjects will receive standard chemotherapy weekly and 4-6 fractions of brachytherapy radiation for 5-6 weeks. While subjects are receiving chemotherapy and radiation, they will also receive the study drug, pembrolizumab.
Environmental exposures, specifically tobacco smoke, increases the risk of many cancers, including bladder cancer. To date, there are no diagnostics capable of detecting bladder cancer early, that is prior to clinical presentation. Because of this severe limitation, nearly 30% of patients initially present with stage 2 and higher bladder cancer. Stage 2 bladder cancer has a 5-year survival of 50%, while stage 3/4 have a 5-year survival of \<20%. Ideally, bladder cancer would be preventable. Unfortunate, this has not come to fruition. If these stage 2-4 bladder cancer cases could be detected at Stage 1 (5-yr survival \>94%), then its possible to see an improvement in bladder cancer survival rates (21-23).

in this study, a urine-based diagnostic that possesses the potential to accurately identify patients who harbor bladder cancer prior to clinical manifestation will be tested.
This invention teaches systems and methods for identifying, targeting and destroying cancer cells. As cells progress from a normal to a cancerous state their accelerated metabolic rates and adapted pathways generate a higher heat signature that serves as a targeting beacon for a specialized cell killing vector. Suitable vectors include modified or adapted viruses, modified or adapted intracellular bacteria and/or engineered liposomes. Especially preferred is the bacterial vector because of its ease of production. The bacterial vector is selectively targeted to recognize cells whose temperature is slightly elevated and ambient pH suppressed due to cancer related alterations to metabolism. An additional targeting feature, such as recognition of the MCT4 transmembrane protein exaggeratively expressed on the cancer cell outer membrane, may provide additional targeting specificity. Embodiments featuring facultative extracellular and intracellular growth capable bacteria have the preferred feature that culture conditions for producing the vector can be optimized solely for the one organism and need not be compromised to support or optimize host cell maintenance.
Protein G HP SpinTrap columns will be used to capture IgG antibodies from patient serum pre-implant, between 2 weeks-3 months, between 3-11 months and between 12-18 months post-implant. These antibodies will be cross-linked to the column and then protein extracted from implant tissue (ie Native bovine/porcine pericardium) will be deglycosylated and run through the column. Antigenic proteins will be trapped and non-antigenic proteins will be washed through the column. These antigenic proteins will be eluted off the column and identified using LC-MS/MS. The proteins identified in the pre-implant elutant will be compared to the proteins in post-implant elutant to identify xenoantigens. Success criteria will be method validation by identification of previously known and new currently unknown xenoantigens.
A total of 300 day-old Arbor Acres Plus broiler chicks (mixed sex) was used to evaluate the effects of dietary supplementation of Bacillus subtilis, Clostridium butyricum, and Enterococcus faecalis mixture (PB) on growth performance, ileal morphology, and cecal microbiota. All birds were randomly assigned into 3 groups based on the initial body weight. There were 5 replicate cages per group and 20 birds per cage. The experimental period was 42 days. Dietary treatments were based on a basal diet and supplemented with 0, 0.05, or 0.10% PB. The results indicated that broiler chicks fed with the diet supplemented with graded levels of PB have quadratically improved their body weight gain and feed intake; the highest value was presented in 0.05% PB-containing group. In addition, villus to crypt ratio linearly increased with the concentration of PB increased in the diet. The alpha diversity linearly increased by PB supplementation, and the highest value was presented in 0.10% PB-containing group. In terms of growth performance, the suitable dose of PB used in the diet was 0.05%. However, ternary plot showed that the harmful bacteria, Escherichia-Shigella, was enriched in 0.05% PB-containing group. In brief, we considered that dietary supplementation of graded levels of PB improved growth performance and regulated cecal microbiota in broiler chicks.
N,N-dimethyltryptamine (DMT) is a naturally-occurring psychedelic substance widely used in recreational and spiritual settings in the form of Ayahuasca. Similar to lysergic acid diethylamide (LSD) or psilocybin, DMT is considered a tool to induce an altered state of consciousness of interest in psychological and psychiatric research. Pharmacologically, DMT interacts with the serotonin 5-HT2A receptor similar to other classic hallucinogens including LSD and psilocybin. The main difference of DMT in comparison with LSD or psilocybin is inactivity when administered orally without monoamine oxidase (MAO) A inhibition and its short action when administered intravenously or by inhalation. In Ayahuasca, DMT is consumed iin combination with harmala alkaloids that inhibit MAO to increase the oral bioavailability of DMT and to prolong its action after oral use. Alternatively, an intravenous administration regime including a bolus and a one hour maintenance perfusion has been proposed to induce a stable and prolonged DMT experience, allowing to study the psychological and autonomic acute effects of DMT. Also, the maintenance perfusion administration allows to end an altered state of consciousness quickly. In the present study this model will be tested using four modified administration schemes. The goal of this study is to experimentally test different intravenous DMT administration schedules to investigate the subjective and autonomic effects of DMT in healthy subjects. The study is expected to inform researchers on dosing regimes of intravenous DMT as a tool to examine alterations of the mind and is of interest for psychology and psychiatry. This study does not intend to provide any therapeutic benefit for the participants. Currently, no study has validly determined the elimination half-life of DMT and other pharmacokinetic parameters. The key aim is to test the dose-response of DMT as well as the difference between the loading dose bolus and no-bolus perfusion conditions regarding pharmacokinetic, subjective, and autonomic effects including psychological and physical tolerability.
No dose reduction for KEYTRUDA is recommended. In general, withhold KEYTRUDA for severe (Grade 3) immune-mediated adverse reactions. Permanently discontinue KEYTRUDA for Life-threatening (Grade 4) immune-mediated adverse reactions, recurrent severe (Grade 3) immune-mediated reactions that require systemic immunosuppressive treatment, or an inability to reduce corticosteroid dose to 10 mg or less of prednisone or equivalent per day within 12 weeks of initiating steroids.

Dosage modifications for KEYTRUDA for adverse reactions that require management different from these general guidelines are summarized in Table 2.

The following table represents dosage modifications that are different from those described above for KEYTRUDA or in the Full Prescribing Information for the drug administered in combination. 

Recommended Dose Modifications for Adverse Reactions for KEYTRUDA in Combination with Lenvatinib

When administering KEYTRUDA in combination with lenvatinib, modify the dosage of one or both drugs. Withhold or discontinue KEYTRUDA as shown in Table 2. Refer to lenvatinib prescribing information for additional dose modification information.
<P>PROBLEM TO BE SOLVED: To obtain an allergen inactivating agent comprising an edible plant extract as an active ingredient and a skin care preparation or an allergen inactivating product comprising the same compounded therein.  <P>SOLUTION: The allergen inactivating agent comprises one or more kinds of extracts having allergen inactivating effects as an active ingredient selected from the plant group of Agrimonia pilosa var. japonica, Hypericum erectum, Camellia sinensis, Salacia oblonga, Vitis spp, Prunellae spica, Cornus officinalis and Chaenomeles speciosa. The skin care preparation, the cosmetic, the sheet and the interior spray each comprises the extract. The allergen is a pollen allergen and/or a mite allergen.  <P>COPYRIGHT: (C)2008,JPO&INPIT
PROBLEM TO BE SOLVED: To provide a new pharmaceutically active pyrrolidine derivative.SOLUTION: The pyrrolidine derivative is represented by general formula I. The compound is preferably used as a pharmaceutically active compound. Specifically, the pyrrolidine derivative represented by formula I is effective for treatment and/or prevention of premature delivery, premature birth and dysmenorrhea. In particular, the pyrrolidine derivative exhibits substantially modulatory, notably antagonistic activity to an oxytocin receptor. More preferably, the compound is effective for treatment and/or prevention of morbidity mediated by oxytocin, including premature delivery, premature birth and dysmenorrhea. There are also provided a novel pyrrolidine derivative and a manufacturing method of the same.
Many grass pollen allergic subjects treated with immunotherapy tablets experience treatment related adverse events when initiating treatment. The adverse events are considered consistent with the introduction of allergens in sensitised subjects. The majority are local allergic reactions within the mouth and/or throat. Most of these reactions are mild or moderate in intensity, have an onset almost immediately after taking a tablet, and last from minutes to hours after intake. Appearance of adverse events in relation to tablet intake tends to subside spontaneously within 1 to 7 days. Thus, initiation of treatment with Grazax may be associated with discomfort. It is anticipated that intake of antihistamine before initiation of Grazax treatment would most likely reduce the discomfort associated with initiation of Grazax treatment. Therefore, the rationale for this trial was to investigate if administration of antihistamine prior to initiation of Grazax treatment results in a reduction of subjects reporting local allergic reactions.
BACKGROUND: Prostate cancer is the second most common cancer among men globally. A range of management options are available for prostate cancer, including surgery, radiation therapy, hormone therapy, chemotherapy, or surveillance. Conservative strategies include active surveillance and watchful waiting, which differ in their intent.
OBJECTIVE: We provide a targeted instructive management algorithm for improving understanding of conservative strategies in prostate cancer.
DISCUSSION: Active surveillance involves close monitoring with curative intent when there is evidence of disease progression. In contrast, watchful waiting is palliative in intent and focuses on delaying treatment until symptoms or complications develop. Conservative approaches have demonstrated similar long-term oncological outcomes to radical treatment, while reducing harm from overtreatment, and maintaining quality of life by avoiding potential side effects such as urinary incontinence and erectile dysfunction. The decision to employ a conservative approach is determined by both patient and disease factors. Conservative management strategies play a vital role in the management of prostate cancer.
The skin around the incision is dissociated from the bottom, followed by measuring the length of the wound and dividing it into three segments evenly. Each segment randomly received 2-0 Vicryl suture, 2-0 PDS suture, or 2-0 Ethibond suture to sew up the incision with WE-MBVMS.This is the group which received 2-0 Vicryl suture to sew up the incision.
PURPOSE: A curing composition containing L-arginine, Acanthopanacis senticosi extract, Eucommiae Cortex extract for impotency is provided, which shows good curing effect to impotency without side-effect. CONSTITUTION: The curing composition for impotency comprises of L-arginine crystalline powder 5-200wt. part, Acanthopanacis senticosi extract containing 0.05-0.45% of eleutheroside 5-30wt. part, Eucommiae Cortex extract containing 0.02-0.12% of genipocidic aid 5-15wt. part. The composition can be prepared in the form of solution, suspension, tablets, capsules, soft capsules, pills or granules. A process for the preparation of Eucommiae Cortex extract comprises of: cutting the Eucommiae Cortex into fine pieces, and pouring into distilled water 10L; boiling for 3hrs in water bath, and filtering after cooling; and concentrating the residual solution to get the genipodic acid contained powder. A process for the preparation of Acanthopanacis senticosi extract comprises of: cutting the Acanthopanacis senticosi into fine pieces, and pouring into distilled water 5L; boiling for 4hrs in water bath, and filtering after cooling; and concentrating the residual solution to get the eleutheroside-contained powder.
Superficial wounds, esp. dental wounds, are covered and protected by a prod. contg. calcium peroxide. The calcium peroxide may be mixed with calcium hydroxide, in a proportion up to total replacement of hydroxide. The peroxide supplies nascent oxygen which compensates for the lack of physiological oxygen and aids survival of dental pulp affected by ischemic gangrene. The calcium peroxide may also be mixed with calcium oxide, and has the advantage of giving a foamed solid, facilitating penetration of probes etc.. The calcium peroxide may be further mixed with sodium peroxide, which modifies the rate of reaction and renders it safer. The prod. is better tolerated and more effective than conventional materials used for dental wounds, such as calcium-or sodium peroxide.
BACKGROUND: Physiotherapists' attitudes and beliefs play a crucial role in the management and treatment outcomes of non-specific neck pain (NSNP).
OBJECTIVE: To investigate the attitudes and beliefs of physiotherapists in Jordan towards NSNP, and to identify factors influencing these attitudes and beliefs.
METHODS: A Cross-sectional survey of registered physiotherapists working in Jordan was conducted. A structured questionnaire was used to assess the attitudes and beliefs of physiotherapists towards NSNP. Descriptive and inferential statistics were used.
RESULTS: A total of 301 PTs completed the survey, 155 females (51.56%). Most respondents held bachelor's degrees, with an average of 9.5 ± 6.6 experience years. The total score for PABS-PT (Z = 11.4, p < 0.001) and its BM (Z = +11.9, p < 0.001) and PS (Z = 3.6, p < 0. 001) subscales were significantly positive. The score of the biomedical subscale was more significantly positive than psychosocial subscale. The treatment orientation was positively correlated with education level, and negatively with age and experience. The most reported treatments were manual therapy followed by general exercises and electrical modalities. No significant relationship was observed between treatment orientation and treatment selection.
CONCLUSION: This study created the initial profile for pain attitudes and beliefs in Jordan. Physiotherapists hold positive attitudes and beliefs towards the NSNP treatment orientations with a superiority of the BM approach. Engaging educational sectors and stakeholders in the current situation of PTs' attitudes and beliefs is important.
Before emergence from anesthesia, the patient will be positioned at 30 degrees, and oropharyngeal secretions will be suctioned. Anesthetic gas or intravenous agents will be stopped. Oxygen levels will be set to 50% with a fresh gas flow of at least 10 L/min. Ventilation mode will switch to pressure support adjusted to achieve similar volumes as controlled ventilation. PEEP levels will remain unchanged, while the minimum respiratory rate will decrease by 4 breaths/min. The inspiratory flow for triggering will be set at 2 L/min.