anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates. MicroRNAs (miRs) are closely related to heart disease, among which miR-574-3p plays an important role in myocardial remodeling, but its role in exercise-mediated cardioprotection is still unclear.
METHODS: A mouse myocardial hypertrophy model was established by transverse aortic coarctation, and a 4-week swimming exercise training was performed 1 week after the operation. After swimming training, echocardiography was used to evaluate cardiac function in mice, and histopathologic staining was used to detect cardiac hypertrophy, myocardial fibrosis, and cardiac inflammation. Quantitative real-time polymerase chain reaction was used to detect the expression levels of miR-574-3p and cardiac hypertrophy markers. Western blotting detected the IL-6 (interleukin-6)/JAK/STAT inflammatory signaling pathway.
RESULTS: Echocardiography and histochemical staining found that aerobic exercise significantly improved pressure overload-induced myocardial hypertrophy (n=6), myocardial interstitial fibrosis (n=6), and cardiac inflammation (n=6). Quantitative real-time polymerase chain reaction detection showed that aerobic exercise upregulated the expression level of miR-574-3p (n=6). After specific knockdown of miR-574-3p in mouse hearts with adeno-associated virus 9 using cardiac troponin T promoter, we found that the protective effect of exercise training on the heart was significantly reversed. Echocardiography and histopathologic staining showed that inhibiting the expression of miR-574-3p could partially block the effects of aerobic exercise on cardiac function (n=6), cardiomyocyte cross-sectional area (n=6), and myocardial fibrosis (n=6). Western blotting and immunohistochemical staining showed that the inhibitory effects of aerobic exercise on the IL-6/JAK/STAT pathway and cardiac inflammation were partially abolished after miR-574-3p knockdown. Furthermore, we also found that miR-574-3p exerts cardioprotective effects in cardiomyocytes by targeting IL-6 (n=3).
CONCLUSIONS: Aerobic exercise protects cardiac hypertrophy and inflammation induced by pressure overload by upregulating miR-574-3p and inhibiting the IL-6/JAK/STAT pathway.
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these studies and reduce the need for veterinary intervention. Here, we leveraged large-scale longitudinal frailty and lifespan data on two genetically distinct mouse cohorts to evaluate noninvasive strategies to predict life expectancy in mice. We applied a modified frailty assessment, the Fragility Index, derived from existing frailty indices with additional deficits selected by veterinarians. We developed an ensemble machine learning classifier to predict imminent mortality (95% proportion of life lived [95PLL]). Our algorithm represented improvement over previous predictive criteria but fell short of the level of reliability that would be needed to make advanced prediction of lifespan and thus accelerate lifespan studies. Highly sensitive and specific frailty-based predictive endpoint criteria for aged mice remain elusive. While frailty-based prediction falls short as a surrogate for lifespan, it did demonstrate significant predictive power and as such must contain information that could be used to inform the conclusion of aging experiments. We propose a frailty-based measure of healthspan as an alternative target for aging research and demonstrate that lifespan and healthspan criteria reveal distinct aspects of aging in mice.
A surgical device controllable by a surgical robotic system is provided. The surgical device includes a housing capable of being coupled to the surgical robotic system; a drive system at least partially mounted in the housing; and a shaft rotatably coupled to the drive system at a first end of the shaft. The surgical device further includes a tissue-removal assembly coupled to the second end of the shaft. The tissue-removal assembly includes a first cutting member having a plurality of rotatable blades. The first cutting member is coupled to a second end of the shaft. The tissue-removal assembly further includes a second cutting member, one or more support elements slidably or fixedly coupled to the second cutting member, and one or more extendable elements slidably or fixedly coupled to the second cutting member.
A system and method for detecting personal protective equipment (PPE) compliance is disclosed. Personal protective equipment, such as gloves, gowns, masks, protective eyewear, may be used to limit transmission of illness either from the patient to the care giver or vice-versa. Compliance with PPE is important in various contexts, including hospital settings, home settings, work settings, and school settings. For example, a healthcare provider may wear a wristband, which may interact with a stationary controller that is associated with an entrance and/or an exit to an area for the patient (such as the stationary controller integrated with or proximate to a hand cleaning agent dispenser) proximate to the entrance and/or exit. The interaction may be used to determine whether the healthcare provider has complied with PPE protocols. Further, the system may be used to train healthcare providers or others in PPE hygiene. In addition, the wristband may be used to check for compliance of a plurality of protocols, such as PPE protocols and hand hygiene (HH) protocols. In this way, the system may be used for safely interacting with patients in order to reduce cross-contamination.
Resistance training at longer muscle lengths induces greater muscle hypertrophy and different neuromuscular functional adaptations than training at shorter muscle lengths. However, the acute time course of recovery of neuromuscular characteristics after resistance exercise at shorter and longer muscle lengths in the quadriceps has never been described. Eight healthy young participants (4 M, 4 F) were randomly assigned to perform four sets of eight maximal isometric contractions at shorter (SL; 50° knee flexion) or longer (LL; 90° knee flexion) muscle lengths in a crossover fashion. During exercise, peak torque (PT), muscle activity [electromyogram (EMG)], and internal muscle forces were assessed. PT and EMG at shorter (PT50, EMG50) and longer (PT90, EMG90) muscle lengths, creatine kinase (CK), and muscle soreness were measured at baseline, immediately after exercise (Post), after 24 h (24 h), and after 48 h (48 h). During exercise, EMG (P = 0.002) and internal muscle forces (P = 0.017) were greater in LL than in SL. During recovery, there was a main effect of exercise angle, with PT50 (P = 0.002), PT90 (P = 0.016), and EMG50 (P = 0.002) all significantly reduced to a greater degree in LL compared with SL. CK and muscle soreness increased after resistance exercise, but there were no differences between SL and LL. The present results suggest that if the preceding isometric resistance exercise is performed at longer muscle lengths, function and muscle activity at shorter and longer muscle lengths are inhibited to a larger degree in the subsequent recovery period. This information can be used by practitioners to manipulate exercise prescription.NEW & NOTEWORTHY Despite the established long-term benefits of training at longer muscle lengths for muscle size and strength, acutely performing resistance exercise at longer muscle lengths may require a longer time course of neuromuscular recovery compared with performing resistance exercises at shorter muscle lengths. Furthermore, there appear to be different joint angle-specific recovery profiles, depending on the muscle length of the preceding exercise.
FIELD: apiculture. SUBSTANCE: method involves placing basic product into hermetically sealed chamber; drying; extracting beebread granules. Drying is performed by convective method at temperature below 45 C which is provided by introducing process air into chamber and discharging air saturated with vapors. Method further involves disinfecting product dried to moisture content of 10-12% by treating with ozone and simultaneously cooling till hardening of product with following extracting of beebread granules; additionally drying product to moisture content below 5%. Process air supply and discharge for drying of basic product as well as for additional drying of beebread granules are performed in closed cycle. Air saturated with vapors is discharged from chamber, dried, heated and directed once more into chamber. Apparatus for reprocessing of beebread dried substance has hermetically sealed heat-insulated chamber, cooling chamber with air ozonizer, ozone recycling device, separator-grinder, chamber for additional drying of beebread granules, and is further provided with closed system for supplying and discharge of process air into basic product drying chamber and chamber for additional drying of beebread granules. Method and apparatus allow biological properties of beebread granules to kept. EFFECT: increased efficiency, enhanced reliability in operation, reduced production cost and improved quality of beebread granules. 5 cl, 1 dwg
PURPOSE: A silk peptide composition having diabetes improving functions is provided to improve diabetes using silk protein and offer a high molecular weight of silk peptide composition which is merely absorbed into the human body. CONSTITUTION: A functional food composition is produced by decomposition of protein and includes an average molecular weight of 10000-100000 of silk protein as an active ingredient. The silk protein is silk sericin or silk fibroin. The silk protein is silk fibroin. The silk protein decomposition is performed by a decomposition method selected from a group consisting of the decomposition of calcium salt solution, acid hydrolysis, decomposition by a mixture solution of calcium salt and ethanol and a combination thereof. The calcium salt is calcium chloride. The calcium salt removal is selected from a method consisting of dialysis, ultrafiltration, gel chromatography, electric desalting and a combination thereof.
Consist of patients who have been diagnosed with mTBI by a doctor at an emergency room or in general practice. The patients must still have symptoms related to their trauma ≥ 2 months and ≤ 24 months after trauma origin. They must not have received any vision therapy from an optometrist in relation to resent mTBI.
This is a single-center, pilot study to assess the feasibility of a study show the effectiveness of the genicular artery embolization (GAE) in reducing arthritic pain and dysfunction associated with mild to moderate Bilateral or unilateral osteoarthritis of the knee. Patients with bilateral or unilateral Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale, will be offered enrollment to the study. Following a screening questionnaire, these patients will then be enrolled in this study. Baseline MRI will be obtained prior to the GAE procedure. Follow up intervals will include 3, 6, 9, and 12 months with the primary objective measured by a clinician as the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score, Knee Injury and Osteoarthritis Outcome (KOOS) score, and Oswestry Disability Index at the 12-month follow up visit. Patients will also undergo 1 year follow up MRI to be interpreted by a diagnostic radiologist with subspecialty training in musculoskeletal radiology. This radiologist will compare the treated knee to the baseline screening according to the WORMS classification (Whole Organ Magnetic Resonance Scoring) to assess for radiologic changes of osteoarthritis and any adverse effects.
PROBLEM TO BE SOLVED: To easily evaluate the in vivo antioxidizing power of a test agent after its oral administration, by applying a photoinducible radical-forming substance to the skin of a test animal orally administering the test agent followed by photoirradiation and then measuring the quantity of radicals formed. SOLUTION: The skin (pref. the skin of the back) of a test animal (pref. a hairless mouse) orally administered with a test agent is coated with a photoinducible radical-forming substance (pref. anthralin) followed by photoirradiation to form radicals, whose quantity is then measured. The radiation for the irradiation is pref. ultraviolet rays. A preferable method of the measurement is such one that the skin of the test animal after subjected to the irradiation is peeled off and then put into a tissue test tube for ESR(electron spin resonance) measurement to determine the radical quantity by the use of X-band ESR. On the basis of the radical intensity of a substance which has been known to have no antioxidizing effect, the evaluation of the antioxidizing power of the test agent can be accomplished through the lowering of its radical intensity.
BACKGROUND: Low socioeconomic status (SES) has been previously associated with delays in orthopaedic care. However, it is unclear how SES impacts patients with adolescent idiopathic scoliosis (AIS), particularly regarding preoperative major coronal curve angle or surgical outcomes. Utilizing the Child Opportunity Index (COI)-an address-driven measure of pediatric education, health/environment, and SES-we investigated whether COI is associated with differences in preoperative scoliosis magnitude, age at surgery, and AIS surgical outcomes.
METHODS: Consecutive patients with AIS surgically treated at a single center from 2011 to 2017 were reviewed. COI was calculated by inserting a patient's home address into the nationally available COI database to derive a COI value. COI is scored from 0.0 to 100.0 (0.0 is lowest, 100.0 is highest). Specifically, COI is categorized as very low (<20.0), low (20 to 39.9), moderate (40 to 59.9), high (60 to 79.9), and very high (≥80). Those without addresses were excluded. Patients without proper radiographs to assess curve correction were also excluded. A COI threshold of 60.0 was used to separate patients into a low (<60.0) or high COI ( ) group based on published COI guidelines. Outcomes, including preoperative curve magnitude, age at surgery, percentage curve correction, operative time (OT), intraoperative estimated blood loss per level fused, length of stay, and complications, were compared across groups. Pearson correlation analysis was used to assess correlations between COI and preoperative curve magnitude, as well as age.
RESULTS: Four hundred four patients were included in the study, and 263 had 2-year follow-up data. Patients were an average age of 14.9 years old (range: 11.2 to 19.8), had a median COI of 76 (range: 4 to 100), and had a mean preoperative major curve angle of 59 degrees (range: 36 to 93). COI was significantly higher for white patients compared with non-white (80.0 vs 40.0, P < 0.001), and higher for non-Hispanic individuals (79.0 vs 15.0, P < 0.001). Patients with Low COI were associated with a lower OT per level fused ( P = 0.003) and decreased postoperative complication risk ( P = 0.02). COI was not associated with preoperative major coronal curve angle, age at surgery, or any other surgical outcomes.
CONCLUSION: COI was significantly lower for non-white patients and those of Hispanic ethnicity. Patients from low COI backgrounds achieved similar surgical results as those from high COI addresses and had a decreased OT per level fused and complication incidence, though the clinical significance of these differences is unknown. Future prospective studies are needed to determine whether these findings are reproducible across other states and health systems.
LEVEL OF EVIDENCE: Level III-prognostic study.
Phycotoxins are purified from a mixture of phycotoxins produced in a continuous process. Cyanobacteria are produced in a continuous culture, then lyzed, the cells pelleted and extracted, and the extract purified using an organic solvent-aqueous mixture and repeated passage through a diatomaceous earth column. The column is washed with acetic acid, then the neosaxitoxin extracted with an alcohol-water mixture. The eluate is passed through activated charcoal columns, which are washed with distilled water to remove the retained pigments and impurities, the further purified by HPLC. In one embodiment, the process produces only neosaxitoxin and saxitoxin. In another embodiment, the process produces only GTX2/3.
Camrelizumab 200mg intravenously, once every 21 days or envafolimab 150mg subcutaneous injection,once a week Endostatin 30mg/d was administered intravenously for 7 days (d1-d7). The interval between Endostatin and next was 2 weeks.
BACKGROUND: Minimally invasive surgery is becoming the method of choice for the resection of esophageal cancer worldwide.
METHODS: Retrospective analysis of prospectively collected clinical data in a tertiary care center with a detailed description of the course of the program.
RESULTS: A total of 136 transthoracic esophageal resections were performed between 2010 and 2023. The study group included 116 operations, 69 of which were fully minimally invasive and 47 hybrid. 80.0% of the study group underwent surgery using a multimodality approach. The median operation time was 431 min (± 103). The R0 resection rate was 100%. Forty-two patients (36.2%) had no postoperative complications. The postoperative Clavien-Dindo > IIIb morbidity was 27%. The postoperative 90-d mortality rate was 1.7%. The average number of lymph nodes removed in the last quarter of cancer patients was 31. The anastomotic insufficiency rate for reoperation was 4% (Ivor-Lewis 4.2%, McKeown 5%).
CONCLUSIONS: With extensive expertise in high-end minimally invasive abdominal and thoracic surgery, implementation of a minimally invasive esophageal resection program with a clinical and oncologic outcome within generally accepted limits is feasible.
The invention provides pills for effectively treating fatty liver. The pills are prepared from the following traditional Chinese medicinal materials: root, root-bark and leaves of Berchemia racemosa Sieb. et Zucc., herba artemisiae annuae, seedlings of Virgate Wormwood, cortex acanthopanacis, fructus cannabis, root of Caragana intermedia Fu et Keng, hyacinth beans, false chinese swertia herb, semen raphani, fructus liquidambaris, herba menthae, spina gleditsiae, all-grass of Lygodium japonicum(Thunb.)Sw., fiveleaf akebia fruits, herba eupatorii and honey. The pills are prepared by taking the traditional Chinese medicinal materials as raw materials, adopting the scientific composition, and adopting the repeated verification of the clinical tests, and accords with the theory of the traditional Chinese medicine science. The pills have the efficacies of soothing the liver and strengthening the spleen, warming the liver and the kidney, clearing heat and promoting diuresis, promoting blood circulation to remove blood stasis, and the like, and have very good treatment effects for the symptoms such as inappetence, tiredness and faintness, nausea, vomiting, and dull pain of the hepatic region or the right upper abdomen of the fatty liver patients, the traditional Chinese medicinal materials are easily available, are safe and effective, and are low in cost, the drug resistance is seldom generated, the preparation is simple, the medicine administration is convenient, and the patients can accept the pills easily.
Pain is a complex problem that complicates recovery and rehabilitation after traumatic injury and surgery. The physician must balance pain management therapies against the potential for side effects and complications. Most of the treatment options for pain are pharmacological and have the potential for serious side effects and drug interactions. A non-pharmacological treatment would reduce the risk of adverse events and likely enhance the overall multimodal pain plan. The purpose of this study is to evaluate the effectiveness of Neuro-Stim System (NSS), a non-pharmacological option that uses electrical current to stimulate neurovascular bundles (nerves) in the ear and possibly the autonomic nervous system, to treat pain and improve sleep. Pain patients will be asked to participate in a study to evaluate the ability of Neuro-Stim System to reduce pain and to treat insomnia. NSS is a Federal Drug Administration (FDA) approved device intended to be used for chronic and acute pain.
Patients will be recruited from both Post-COVID19 and Sleep Clinics run through Beaumont Hospital, Beaumont, Dublin, Ireland. This will allow for the recruitment of patients with and without a history of SARS-CoV-2 infection.
The invention discloses a ball-milling coupling extraction integrated process for strengthening natural plant active ingredient extraction. The process mainly includes the steps of: 1. raw material cleaning and drying; 2. raw material coarse grinding; 3. ball-milling grinding; 4. extraction; 5. centrifugation; and 6. concentration and drying. The invention adopts a particle ball-milling grinder to grind natural plants, and the rotation speed, time and ball particle number are set according to different materials. Ball-milling tends to micronize material particles, promote the release of effective active ingredients, and substantially improves the extraction rate of natural products. The products obtained by the invention are crude natural products, which can be further purified so as to be used in medicines, health care products and the like according to different uses. The natural plant effective active ingredients involved in the invention mainly refer to polyphenol materials, polysaccharides, quinones and saponins, etc.
The invention relates to a traditional Chinese medicine for treating chronic enteritis. Enteritis is generally caused by virus and bacterium propagation or diets, and is clinically divided into acute enteritis and chronic enteritis. The chronic enteritis has indigestion, stomachache, diarrhea and other symptoms when attacks. The chronic enteritis affects normal work and life of people. Many medicines for treating the chronic enteritis exist in the present market, but have high cost. The traditional Chinese medicine for chronic enteritis is prepared to solve the above problem. The traditional Chinese medicine has the efficacy of digestion helping, diarrhea stopping and pain relieving. The traditional Chinese medicine for treating chronic enteritis is prepared from pure traditional Chinese medicines, and the concrete formula of the traditional Chinese medicine comprises white peony root, Poria cocos in Yunnan, cassia twig, Radix Codonopsis, Fructus Amomi, dried fruits of Terminalia chebula Retz., Caulis Perillae, dried orange peel, Divaricate Saposhnikovia Root and Rhizoma Alismatis.