anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: The purpose of this study was to determine the influence of hyperlipidemia and statin (hydroxyl-methylglutaryl-coenzyme-A reductase inhibitors) use on fatty infiltration (FI) of the rotator cuff muscle after arthroscopic rotator cuff repair (ARCR). The presence or absence of statin use and type of statins used (type 1 naturally derived statins and type 2 synthetic statins) were examined.
METHODS: This was a retrospective review of 620 cases (620 shoulders) who underwent arthroscopic rotator cuff repair. Total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG) levels, and statin use were reviewed with the medical records. FI of the cuff muscles and repair integrity were assessed by MRI. A generalized linear model was used to analyze the progression of fatty infiltration. Repair integrity was determined according to the Sugaya classification, with types 4 and 5 as retears.
RESULTS: The mean age was 66.9 years (272, females). The overall retear rate was 16.1%. There was no significant difference in retears between statin use and non-use with a trend toward higher retear rates in the type 2 statins. FI progressed postoperatively, and multivariate regression showed that type 2 statin use was a significant risk factor (p = 0.006). Other significant risk factor were large-to-massive tear (p = 0.02) and retear (p < .0001).
CONCLUSIONS: The progression of FI after ARCR was observed. The new generation of strong statins (type 2 statins) was a significant risk factor for the progression of postoperative fatty infiltration, while neither serum lipid level (TC, LDL, and TG) was significant.
The present invention provides a method of separating a virus isolate, in particular an attenuated virus isolate, form a mixed pool of viruses. In the method the viral genetic information is cloned into a vector, thus creating a vector library of the viral pool. The verctors are used to transfect host cells which are then grown up and separated into individual clones. The virus isolate required can be reconstituted from the relevant transformed clone. Using this technique with respect to Chicken Anaemia Virus an attenuated virus was isolate. The invention provides this isolate, the genetic sequence of this isolated and a vaccine against Chicken Anaemia Virus.
Baby SPA application time: It is done regularly from the first month, at least once a month. The ideal time for application is the first six months. The water in the tub is prepared to be 33°C. The baby, whose clothes are taken off, wearing a waterproof diaper suitable for the tub and a neck ring, is taken into the tub. The application usually takes 10-15 minutes, depending on the baby's reactions to the water for the first time. After the parent and baby get used to the process, the time can be increased to 30 minutes. In this process, the baby's hands, abdomen, and legs are made to recognize the water and the baby's movements are monitored. Care is taken that the baby does not drink the water. After the application period is over, the baby is removed from the tub and dried with a towel. Finally, the baby is massaged for 10-15 minutes and dressed.
<P>PROBLEM TO BE SOLVED: To provide milk beverage having high preservation stability and excellent flavor and continuously ingestible even by elderly patients without difficulty and to provide an osteoarthritis ameliorating agent.  <P>SOLUTION: The milk beverage is formulated with 0.025-37.5 mass % of a glycocomposition containing 80-90 mass % of N-acetylglucosamine and 10-20 mass % of chitinoligosaccharide. The milk beverage is continuously ingestible even by elderly patients without difficulty. Since it is possible to intake mineral such as calcium and magnesium and good quality protein each forming muscles and bones and useful for preventing arthrosis together with N-acetylglucosamine, excellent osteoarthritis ameliorating effect can be expected owing to the multiplier effect of the components. Since N-acetylglucosamine has higher stability to pH and heat compared to glucosamine salt and is free from browning and decomposition by pH or heat, the milk beverage has excellent preservation stability and flavor.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Tooth loss or edentulism is a major dental problem worldwide, particularly among the senior population. A recent study in Singapore found that approximately one third of adults aged over 60 are living with complete edentulism. Prevalence of partial edentulism in this population is estimated to be even higher. The high prevalence of tooth loss has resulted in great needs and demands of prosthetic replacements, posing challenges to the public dental care system in Singapore. Removable denture prosthesis is the most commonly used device to replace missing teeth and restore oral functions. The removable denture prosthesis possesses a metal framework that connects the clasps, retainers, base and acrylic teeth, to ensure rigidity and stability while in function. However, the current way of fabricating denture frameworks using casting method is a time consuming, complex, error-prone, and expensive process. Due to the inherent inaccuracies in the materials and technique, the fit of the framework is compromised and undesirable to meet patients' satisfaction. With recent developments in computer aided design and additive manufacturing, commonly known as 3D printing or rapid prototyping, the techniques allow for printing of complex metal structures of high strength, stiffness and chemical resistance. This proposal aims to compare the precision and fit, and patient's satisfaction, of 3D printed denture frameworks and eventually translate this to a more efficient denture fabricating process.

The removable denture prosthesis is the most commonly used device to replace missing teeth and restore oral functions in patients with partial and complete edentulism. The fabrication of framework using conventional methods is time consuming and inaccurate. Thus the ultimate goal of this study is to enhance the workflow efficiency, improve the fabrication precision of the device, reduce treatment cost and time, and promote oral function and overall quality of life of patients. At the same time, the research methods developed from this study is a platform for the study of new dental devices, with potential applications for new digital dental practices. Thus, if successful, the deliverables from this research will both advance dental research, and extend applicable knowledge to the clinic.
The invention provides a water dispersible composition for repairing and maintaining skin barrier and application thereof. The composition takes hydrogenated phosphatidylcholine as a carrier, and a water-dispersible composition is designed and prepared according to the basic structure and biochemical composition of skin and based on the iron trigonal factor of the skin barrier, so that the design and application of a cosmetic formula are facilitated. The composition mainly comprises ceramide, indian fruit seed oil and squalane. Real-time fluorescent quantitative PCR and a percutaneous resistance test show that the composition can remarkably up-regulate the gene expression level of silk polymerization protein and keratin 10 and remarkably improve the percutaneous resistance value. And the squalane, the seal fruit seed oil and the ceramide have synergistic effect of synergistically repairing skin barriers. The composition can be applied to cosmetics for repairing damaged skin barrier, enhancing skin barrier, and relieving skin discomfort.
PROBLEM TO BE SOLVED: To obtain a cosmetic having a good feeling to a skin and remaining property on its application and excellent in compatibility by blending a collagen having a specific relative angle of rotation with the cosmetic. SOLUTION: This cosmetic containing a collagen is obtained by preparing the collagen having (-)180-130 deg. relative degree of rotation and not recognized to contain low molecular weight molecules of <=100,000 molecular weight without damaging the chemical structure of the collagen, and blending the collagen to a cosmetic. The collagen is obtained by breaking up a triple helices structure specific to the collagen without cutting the peptide bond of the collagen molecular chain. The collagen is a collagen molecular chain modified moderately by a heating and can be obtained by moderately heat-treating the collagen extract liquid under a neutral condition and then performing a fractional purification with an ultrafiltration membrane. Finally it is desirable to pass a membrane filter for removing bacteria.
The invention relates to a device for assembling sets of instruments, having a data processing installation and a fine identification unit. The data processing installation has a display unit, a database, a first interface and an evaluation unit. The fine identification unit has a first support for placing the instruments of a set of instruments thereon and a first camera. The first camera is arranged and oriented such that it can capture image data from instruments to be identified and arranged on the first support from at least one perspective, and the data processing installation is designed such that it uses the first interface to receive image data from the first camera and can store the received image data in the database. It can further visually identify a respective instrument by use of the evaluation unit. The invention also relates to an according method for assembling sets of instruments.
In recent decades, new cancer cases have consistently risen. Participants diagnosed with cancer commonly face psychological symptoms including distress, anxiety, and depression in addition to physical symptoms (i.e., pain). Importantly, these symptoms might be exacerbated during chemotherapy sessions. New innovative technological strategies have been under development to control the symptoms and improve quality of life. Immersive virtual reality (VR) is a simulated experience that enables participants to interact with an artificial three-dimensional visual and auditory environment. VR could be an innovative intervention to relieve psychological symptoms associated with chemotherapy.
Mapracorat dose dependently inhibited the TNFa secretion from activated canine PBMC with an IC 50  value of approx. 0.2 nmo1/1. Intradermal injection of compound 48/80 (50 μg in 50 μ1 saline), resulted in a clear wheal and erythema reaction over the 60 min observation period in vehicle (acetone) treated areas. Topical pre-treatment with mapracorat (0.1%) and triamcinolone acetonide (0.015%) led to significant reduction in wheal and erythema area. A once daily topical administration of triamcinolone acetonide significantly reduced skin fold thickness from day 8 to day 14, whereas no such reduction was observed for mapracorat. Taken together, in vitro and in vivo experiments demonstrate that mapracorat has comparable antiinflammatory efficacy to triamcinolone acetonide, while skin fold thickness indicates a better safety profile compared to steroidal glucocorticoids at equi-effective dosages. This profile further suggests that it is of particular advantage in the treatment or control of any inflammatory and pruritic skin diseases in dogs.
The present invention relates to a mask pack with a cutting line, which is easy to unfold and provides a simple folding method and working step even for an unskillful worker in manufacturing to save time. More specifically, to be adapted to a three-dimensional (3D) facial shape and be fit to a curve, the mask pack with a cutting line cuts each corner side of a rectangular sheet (f1) to form total four cutting lines (112). A grip protrusion, that is, a cutting line-extended grip protrusion (120′) has an outer edge (111) and a cutting line-extended outer edge (112′). The cutting line-extended outer edge (112′) is continuously extended from an original cutting line (112) to the outside to completely cut the sheet (f1) up to the edge of the rectangular sheet (f1). A sheet fragment (f2) is completely cut off from the sheet (f1) by the outer edge (111) and the cutting line-extended outer edge (112′) and occupies a small portion, thereby reducing waste of a material. The cutting line-extended grip protrusion (120′) is formed at all corners of the sheet (f1).
Placebo for ixekizumab administered by two SC injections at Week 0, then one SC injection per Dosing Regimen 1 until Week 12. At Week 12, placebo responders are assigned to placebo, and nonresponders to Dosing Regimen 2. Placebo for etanercept administered by one SC injection twice weekly starting at Week 0 up to Week 12 was used to blind etanercept injections for Dosing Regimen 1, Dosing Regimen 2, and Placebo Comparator groups.
PURPOSE: To obtain a medicine which contains an effective amt. of the solution of a specific surface active copolymer having an oxyalkylene group constituting a hydrophobic part and a hydrophilic part and effectively prevents the tissue damage accompanying the revascularization in an animal or a human body. CONSTITUTION: The effective amt. of the surface active copolymer consisting of the ethylene oxide-propylene oxide copolymer having the formula [(a) is an integer and is so selected that the hydrophobic part expressed by (C3 H6 O) has a mol.wt. of about 950 to 4000; (b) is an integer and is so selected that the hydrophilic expressed by (C2 H4 O) constitutes about 50 to 90 wt.% of this surface active copolymer] is dissolved into a salt water. The desired medicine for preventing the tissue damage which contains the surface active copolymer at a concn. of 1 wt.% and is capable of effectively preventing the tissue damage accompanying revascularization procedure in the animal or human body, such as balloon revascularization, endarterectomy and laser procedure, is thereby obtd.
"Exercise is the best medicine" is well known, but the optimal dose of physical activity (PA) for males and females across different age groups is still unknown. This study, using data from the four waves of CHARLS, aimed to determine the optimal PA dose that reduces frailty risks among older adults across various age groups and both sexes. We created a frailty index score using 63 health-related variables and used 0.21 as the frailty cut point. Binary logistic regression was used to compare the effect of vigorous, moderate, and light intensity PA under IPAQ criteria on frailty risk. The study found that regardless of whether males or females, the optimal effect of vigorous-intensity PA in reducing the risk of frailty is consistently observed throughout the entire old age career. Moreover, the age groups at which moderate-intensity PA reduces the risk of frailty were from age 70 for males and from age 80 for females. And light-intensity PA had no effect on reducing the risk of frailty. Moderate and vigorous intensity of PA in older adults should be promoted, but guidelines and recommendations must account for optimal associations with PA dose across genders and age groups.
PROBLEM TO BE SOLVED: To obtain the subject composition capable of expressing preventing and curing activities for diseases accompanied with bone-weight decrease, hypertension, etc., by bringing the composition to contain a stilbene compound included in polygonaceous plants, vitraceous plants, etc. SOLUTION: This medicinal and food composition containing a stilbene-based compound contains at least one species selected from compounds expressed by the formula [A and B are each a halogen, amino, amidino, anilinoamide, mercapto, sulfonic acid, etc.; (n) and (m) are each 0-5], (e.g. 4,4'-stilbene diol, 3,5-stilbene diol, etc.), and its polymers as effective ingredients. The compound of the formula and its polymer are preferably originated from one or more of plants selected from a group comprising polygonaceous plants, vitaceous plants, Veratrum grandiflorum, mulberry and peanut. The composition preferably contains vitamin C, vitamin D and vitamin K. The composition is effective for preventing or curing diseases accompanied by bone weight loss, preferably osteoporosis and the like.
Participants in stratum W2 will undergo standard dose craniospinal radiation with boost to the primary tumor site once daily 5 days a week for 6 weeks. Six weeks after completion of radiotherapy, patients receive one cycle of chemotherapy (cisplatin, vincristine, cyclophosphamide) once every 4 weeks for 4 cycles in absence of unacceptable toxicity. Some participants will complete aerobic training and/or neurocognitive remediation.
A niosome having a metal porphyrin complex embedded therein which contains a cationized metal porphyrin complex and a niosome-forming substance. This niosome having a metal porphyrin complex embedded therein has an SOD activity and can target super oxide anion radical (O2-.) and surely decrease it. Because of being in the form of a niosome, it can be delivered to, for example, a cancer cell in vivo. Therefore, it can decrease O2-. in a cancer cell and exert an excellent effect of treating cancer. Moreover, it shows a selective effect and, therefore, is usable as a novel anticancer agent with no side effect. In addition, it can be hold in the blood, which makes it favorable as an antioxidant. Owing to this characteristic, it can protect the living body from in vivo disorders caused by active oxygen.
The given invention is related to the field of medicine, namely to experimental research in oncology, and can be used to obtain a pharmaceutical agent for inhibiting the proliferation of HeLa cervical cancer cells. It entails the use of a metal powder obtained in a gaseous medium by means of an electric explosion of a wire made of low-carbon steel carried out with a specific energy of 7-18 kJ/g and a pulse duration of 1.2-2 µs. The explosion is carried out inside a reactor that is pre-evacuated to a residual pressure of 10 -2  Pa, and then filled with carbon monoxide to a pressure of 10 5  Pa at a gas circulation rate flow of 10 m/s. The products of the explosion deposited in a hopper are passivated in air for at least 48 hours. The resulting powder is extracted and mixed with a solution of the RPMI-1640 nutrient medium with L-glutamine, a pH of 7.2, in the proportion of the mass of the powder to the volume of the specified solution from 1:10 to 2.7: 10. The solution is then centrifuged until the phases are separated. The liquid phase is decanted and used as a pharmaceutical agent. The purpose of the given invention is to expand the arsenal of tools for inhibiting the proliferation of tumor cells.
PROBLEM TO BE SOLVED: To speedily return to the picture of the consultation day of this time by time sequentially storing information units having basic data for display corresponding to consultation information, expanding the data for display in a display memory on the basis of the basic data for display including an instructed information unit, and displaying the information on a display on the basis of these expanded data for display within a display range. SOLUTION: The consultation information is stored in a consultation information file 31 for every consultation day, and every consultation day has a consultation day ID. Data in this consultation information file 31 are read out and time sequentially stored in a basic data memory 24 for display as basic data for display required for displaying the consultation information. The data in this basic data memory 24 for display are read out and expanded in a memory 23 for display. Besides, the consultation day ID is read out of the consultation information file 31 and stored in a consultation day ID memory 26. The consultation day ID memory 26 is referred to when finding out continuous consultation days in the case of returning to the consultation day selected at present.
<P>PROBLEM TO BE SOLVED: To obtain a lipid peroxide eliminator which can eliminate a produced lipid peroxide to remove adverse effects caused by the lipid peroxide.  <P>SOLUTION: This lipid peroxide eliminator is characterized by containing an electron-imparting anti-oxidizing substance and a peroxidase. The electron-imparting anti-oxidizing substance preferably comprises one or more of ascorbic acid, polyphenol compounds, quercetin, capsaicine, caffeic acid, guaiacol, and propyl gallate. The lipid peroxide eliminator exhibits a more excellent lipid peroxide-eliminating action than those of conventional anti-oxidizing agents and glutathione system compounds, when added to a target such as a food, a cosmetic composition or a medicine composition. Also, the lipid peroxide eliminator inhibits the deterioration of a quality due to the lipid peroxide, and can improve storability and stability.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Hyperfunction of the dopamine system has been implicated in manic episodes in bipolar disorders. How dopaminergic neuronal function is regulated in the pathogenesis of mania remains unclear. Histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei. Here, we present mice lacking dopaminergic histamine H2 receptor (H2R) in the ventral tegmental area (VTA) that exhibit a behavioral phenotype mirroring some of the symptoms of mania, including increased locomotor activity and reduced anxiety- and depression-like behavior. These behavioral deficits can be reversed by the mood stabilizers lithium and valproate. H2R deletion in dopaminergic neurons significantly enhances neuronal activity, concurrent with a decrease in the γ-aminobutyric acid (GABA) type A receptor (GABAAR) membrane presence and inhibitory transmission. Conversely, either overexpression of H2R in VTA dopaminergic neurons or treatment of H2R agonist amthamine within the VTA counteracts amphetamine-induced hyperactivity. Together, our results demonstrate the engagement of H2R in reducing VTA dopaminergic activity, shedding light on the role of H2R as a potential target for mania therapy.
On MR enterography, the Magnetic Resonance Index of Activity (MaRIA) and Magnetic Resonance Enterography Global Score (MEGS) were used to characterize intestinal inflammation by assessing intramural and extramural lesions in both the small and large intestines. In ileocolonoscopy, the Simplified Endoscopic Activity Score for Crohn's Disease (SES-CD) was used to quantify mucosal or luminal lesions from the terminal ileum to the colorectum. Both modalities were used to classify patients with no-to-mild or moderate-to-severe inflammation. We defined patients as having moderate-to-severe inflammation when at least two of the following criteria were met: (1) MaRIA≥11; (2) MEGS≥ 10 for the small bowel or MEGS≥12 for the colon; or (3) SES-CD≥11. Otherwise, patients were categorized as having no-to-mild inflammation.
This study proposes the beta-emitting radioisotope 143Pr as a promising candidate for palliative treatment of metastatic bone pain due to its desirable physical decay characteristics. An optimized process was developed for the production and purification of non-carrier-added 143Pr using a medium flux research reactor. Calculations were performed to determine the optimal irradiation time and cooling period for irradiating 1 mg of natural cerium oxide to indirectly produce 143Pr through the decay of 143Ce. Following irradiation and cooling, extraction chromatography was employed to efficiently isolate 143Pr from the irradiated target material. A column containing Ln-resin was used along with nitric acid as the mobile phase and an optional oxidation step with NaBrO3/ascorbic acid to separate 143Pr from impurities such as 143Ce and 141Ce. Radionuclidic purity of over 99.995% was achieved as confirmed through gamma spectroscopy, demonstrating effective separation of 143Pr. Additional quality control analyses established the chemical and radiochemical purity of the purified 143Pr nitrate product. With a half-life of 13.6 days and maximum beta energy of 0.937 MeV, 143Pr exhibits favorable properties for palliative bone pain therapy. This study therefore provides a viable method for producing high-purity 143Pr through the optimized irradiation and purification processes described. Further investigation is warranted to explore potential clinical applications of 143Pr for palliation of metastatic bone cancer pain.