anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Stage IV colorectal cancer is a highly challenging condition to treat, with 5-year survival rates of 13% in Australia, improving to 40% for those patients with locally recurrent rectal cancer who are suitable for total neoadjuvant therapy and pelvic exenterative surgery. This study reports a unique case of a patient with Stage IV locally recurrent rectal cancer (LRRC), who designed and implemented a holistic integrative oncology intervention.
CASE PRESENTATION: The patient was 59-years-old when diagnosed with Stage IV locally recurrent rectal cancer, and referred to a highly specialised centre for colorectal cancer care at a tertiary teaching hospital in Sydney, Australia. Treatment included chemo/radiotherapy, liver resection and posterior pelvic exenteration surgery. The patient's background as a health researcher and clinician optimised her ability to design and implement an integrative oncology model of care, including yoga, mindfulness, Buddhist meditation and study, social connection, exercise, psychotherapeutic and nutritional support. This paper describes these mind-body practices and lifestyle modifications and outlines her experiences and outcomes at each stage of her extensive and radical treatment.
CONCLUSION: This case provides a unique perspective into how the integration of mind-body practices and lifestyle modifications with conventional treatment can support those living with colorectal cancer.
The invention relates to a preparation for improving the blood supply. The problem with prior art preparations or processes resides in the fact that soft magnetic components had to be introduced into the body in capsule form or a magnetic field had to be applied after tne application of demagnetised particles to the skin. The purpose of the invention is to provide a novel preparation for improving the blood supply in which special hard magnetic particles are used. According to the invention, the preparation for improving the blood supply consists of a pharmaceutically or cosmetically acceptable medium and possibly further additives containing finely distributed hard magnetic single-grade particles with a high coercitive field intensity and grain sizes in the ranp of 600 to 1200 nrn. Dispersions of this preparation exhibit no aggregation of the hard magnetic particles. The preferred use is in the cosmetic and dermatological field.
HCM is the most common inherited cardiovascular disorder. It is characterised by left ventricular (LV) myocardial hypertrophy and fibrosis. Patients can experience symptoms of effort intolerance, progressive heart failure and abnormal heart rhythms. There are currently no treatments that alter the natural history of HCM. Patients and the cardiovascular field have identified a "critical need" for clinical studies of drug therapies that target HCM pathophysiological mechanisms.

Trientine dihydrochloride is a copper-chelating agent licensed for Wilson disease, a genetic disorder of copper excretion, in which patients exhibit a cardiac phenotype that mimics HCM. Proof of concept has been established through an MRC-funded study to suggest that use of trientine may also be beneficial in HCM.
OBJECTIVE: Aim: To determine the economic feasibility of using kidney transplantation compared to hemodialysis in end-stage renal disease in the long term in countries with a low and medium level of economic development using the example of Ukraine.
PATIENTS AND METHODS: Materials and Methods: The cost effectiveness analysis method was used. Conducted Markov modeling and comparison of the consequences of kidney transplantation and hemodialysis in terms of treatment costs and the number of added years of life for a cohort of 1,675 patients were carried out. The incremental cost-effectiveness ratio is defined.
RESULTS: Results: Based on the results of modeling, it was determined that among 1,675 patients with end-stage kidney disease in Ukraine, 1,248 (74.5%) will remain alive after 10 years of treatment when kidney transplantation technology is used. The highest costs will be in the first year ($25,864), and in subsequent years - about $5,769. With the use of hemodialysis technology, only 728 patients (43.5%) will be alive after 10 years, the cost of treating one patient per year is $11,351. The use of kidney transplantation adds 3191 years of quality life for 1675 patients compared with hemodialysis (1.9 years per patient).
CONCLUSION: Conclusions: Kidney transplantation is an economically feasible technology for Ukraine, as the incremental cost-effectiveness ratio is $4694, which is 1.04 times higher than Ukraine's GDP per capita. The results of the study allow us to recommend that decision-makers in countries with a low and medium level of economic development give priority in financing to renal transplantation.
Background: Diarrhea is a major cause of mortality and morbidity in under-5 children globally, especially in developing countries like Ethiopia. Limited research has used machine learning to predict childhood diarrhea. This study aimed to compare the predictive performance of ML algorithms for diarrhea in under-5 children in Ethiopia. Methods: The study utilized a dataset of 9501 under-5 children from the Ethiopia Demographic and Health Survey 2016. Five ML algorithms were used to build and compare predictive models. The model performance was evaluated using various metrics in Python. Boruta feature selection was employed, and data balancing techniques such as under-sampling, over-sampling, adaptive synthetic sampling, and synthetic minority oversampling as well as hyper parameter tuning methods were explored. Association rule mining was conducted using the Apriori algorithm in R to determine relationships between independent and target variables. Results: 10.2% of children had diarrhea. The Random Forest model had the best performance with 93.2% accuracy, 98.4% sensitivity, 85.5% specificity, and 0.916 AUC. The top predictors were residence, wealth index, and child age, number of living children, deworming, wasting, mother's occupation, and education. Association rule mining identified the top 7 rules most associated with under-5 diarrhea in Ethiopia. Conclusion: The RF achieved the highest performance for predicting childhood diarrhea. Policymakers and healthcare providers can use these findings to develop targeted interventions to reduce diarrhea. Customizing strategies based on the identified association rules has the potential to improve child health and decrease the impact of diarrhea in Ethiopia.
BACKGROUND: Inflammation and oxidative stress have drawn more and more interest in the realm of cardiovascular disease. In many different disorders, IL-37 acts as an anti-inflammatory and suppressor of inflammation. This study aimed to investigate whether IL-37 could alleviate cardiac hypertrophy by reducing inflammation and oxidative stress.
METHODS: In vivo, a cardiac hypertrophy model was induced by 14 d of daily isoproterenol (ISO, 30 mg/kg/d) injection, followed by weeks of treatment with recombinant human IL-37 (1000 ng/animal), administered three times weekly. Assessments concentrated on markers of inflammation and oxidative stress, apoptosis, myocardial disease, and cardiac shape and function. In vitro, neonatal rat cardiomyocytes (NRCMs) were subjected to ISO (10 µM) to establish a cardiomyocytes hypertrophy model. Subsequent IL-37 treatment (100 ng/ml) was applied to determine its cardioprotective efficacy and to elucidate further the underlying mechanisms involved.
RESULTS: Significant cardioprotective benefits of IL-37 were seen (in vitro as well as in vivo), primarily through the reduction of oxidative stress, inflammation, apoptosis, and heart hypertrophy markers. Furthermore, IL-37 treatment was associated with a decrease in JAK2 and STAT3 phosphorylation. It is interesting to note that WP1066, a JAK2/STAT3 inhibitor, exhibited antioxidant and anti-inflammatory properties comparable to IL-37, as well as synergistic effects when mixed with the latter.
CONCLUSION: ISO-induced cardiac hypertrophy is lessened by IL-37 through the reduction of oxidative stress and inflammation. Additionally, the effects of IL-37 are closely related to inactivation of the JAK2/STAT3 signaling pathway. It is anticipated that IL-37 will one day be used to treat cardiovascular illnesses such as heart hypertrophy.
Renal fibrosis is a common manifestation in the progression of chronic kidney disease (CKD) to kidney failure. Currently, there is no available therapy to prevent the progression of renal fibrosis. Poricoic acid A (PAA) isolated from Poria cocos shows notable antifibrotic effects. However, its potential mechanism is still unclear. This study aimed to evaluate the effects and the potential mechanisms of PAA against renal fibrosis. A mouse model of renal fibrosis was established using unilateral ureteral obstruction (UUO). We showed that PAA administration significantly alleviated renal lesions and collagen deposition in UUO mice. Mice with UUO resulted in epithelial-to-mesenchymal transition (EMT) and the activation of endoplasmic reticulum stress (ERS) in the renal tissues, while PAA treatment significantly inhibited EMT and ERS activation. Additionally, PAA markedly alleviated ERS-mediated apoptosis in UUO mice. Molecular docking results indicated that PAA stably combined to GRP78 and ATF4. In conclusion, these results demonstrated that PAA possesses a significant bioactivity against renal fibrosis and its treatment mechanism might be the inhibition of ERS-mediated apoptosis.
For one of the two studies to be performed in random order, the subject will receive an infusion of glucagon at a low rate that is designed to mimic basal plasma glucagon concentration. The IV glucagon will be administered at a rate of 0.65ng/kg/min.
ZnO nanoparticles (NPs) are used in skin treatments and cosmetics, the toxicity of long-term and continuous exposure to ZnO NPs is unknown. Mice with epidermal barrier dysfunction revealed melanoma-like lesions after continuous exposure to ZnO NPs. However, the effects of metallic NPs on the skin microenvironment and immune system remain poorly understood. Mice with epidermal barrier failure were given continuous exposure to ZnO NPs for 7 weeks. The malignant transformation of melanocytes was induced with ZnO NPs 2.5 μg/ml for 72 h exposure. The supernatant of the culture medium from dendritic cells after being exposed to 10 μg/ml ZnO NPs for 24 h was applied to melanocytes to explore the effect of recruitment of DCs. The expressure of ZnO NPs resulted in a tendency of malignant transformation of melanocytes, the recruitment of DCs induces this process by produce inflammatory factors such as TNF-α. These DC-produced inflammatory factors, which were induced by ZnO NP exposure, increased the production of matrix metalloproteinases in melanocytes and expedited the malignant transformation process. Our findings revealed that the disrupted cutaneous microenvironment by ZnO NPs penetrated directly promoted the malignant transformation of melanocytes, which process also indirectly enhanced by the TNF-αsecreted from the recruited DCs.
PROBLEM TO BE SOLVED: To obtain the subject composition having excellent maintenance with time, capable of improving unevenness of coating at a very small part, by including a bis(alkylaminocarbonylamino)cyclohexane catalyst having a specific structure. SOLUTION: This composition contains a compound of the formula (R is a 8-22C straight-chain or branched alkyl or alkenyl). The compound of the formula I is preferably obtained by condensing diaminocyclohexane with an alkyl isocyanate. The position of amino group of diaminocyclohexane is preferably 1,2-position. A trans-isomer containing a trans-stereostructure of amino group is physically preferable. An equivalent mixture is economically preferable. 1,2-Bis(stearyl aminocarbonylamino)cyclohexane is preferable as the concrete compound of the formula.
The invention relates to the technical field of polypeptide drug research and development. Specifically disclosed are polypeptide VKTP-Vf13, pharmaceutical compositions and uses thereof. The polypeptide is derived from zebra spiders and comprises the following polypeptides of A1 or A2: a polypeptide with an A1 amino acid sequence of SEQ ID NO. 1; the amino acid sequence A2 is polypeptide which is obtained by substituting and/or deleting and/or adding a plurality of amino acid residues in the amino acid sequence of SEQ ID NO.1, has the identity of 90% or more with the SEQ ID NO.1 and has the same function with A1. The polypeptide specifically inhibits FXIa, has little inhibition effect on FXIa and FXa, and has small bleeding risk and obvious anticoagulation effect. Has the pharmaceutical characteristics of easy preparation by a prokaryotic expression mode and good water solubility, is suitable for treating thrombus diseases, has good clinical application prospect, and can be used as candidate molecules of alternative drugs or auxiliary drugs of the existing anticoagulation drugs.
Making support involves applying to support magnetic substances exhibiting non-zero magnetic susceptibility; silicone compounds (X' and Y') and catalyst, where X' and Y' are react together by hydrosilylation reaction in presence of catalyst or by condensation reaction optionally in presence of catalyst. The exposure to magnetic field of portion of substances moves and/or orientates the substances. Making support involves applying to support magnetic substances exhibiting non-zero magnetic susceptibility; silicone compounds (X' and Y') and catalyst, where X' and Y' are react together by hydrosilylation reaction in presence of catalyst or by condensation reaction optionally in presence of catalyst. The exposure to magnetic field of portion of substances moves and/or orientates the substances. The exposure takes place before interaction between X' and Y' is complete, so that their interaction does not excessively conflict with modification in orientation or with movement of substances under effect of magnetic field. An independent claim is included for kit comprising a magnetic device to generate a magnetic field and at least two compositions packaged separately. The kit comprises compound X', compound Y' and at least one catalyst, where the compounds X', Y' and catalyst are not present simultaneously in the same composition. The magnetic device is capable of creating a magnetic field, which is able to modify the orientation and/or the position of the magnetic substances inside the deposited layer, when a support covered with a deposited layer comprising at least the magnetic substances is introduced into the magnetic field.
Food deprivation has been associated with the development of metabolic pathologies. Few studies have explored the repercussions of a partial food deprivation following the reestablishment of an ad libitum diet. This study investigates the impact of a partial food deprivation (an 8-hour food intake restriction coupled with a 4-hour feeding window during the active phase) and the subsequent return to ad libitum feeding on the glycemic curve, food intake, and locomotor behavior. Wistar rats aged 45 days were subjected to 6 weeks of a partial food deprivation followed by 6 weeks of ad libitum feeding. Body weight, visceral fat, food intake, circadian glycemia, oral glucose tolerance, and locomotor activity were evaluated. It was found that the partial food deprivation resulted in the reduction of both the body weight and food intake; however, it increased visceral fat by 60%. Circadian glycemic values were altered at all intervals during the light phase, and glucose sensitivity improved at 60 minutes in the oral glucose tolerance test (OGTT). In the food-deprived group, the locomotor activity rhythm was reduced, with an observed delay in the peak of activity, reduction in total activity, and a decrease in the rhythmicity percentage. After the reestablishment of the ad libitum feeding, there was recovery of body weight, no difference in visceral fat, normalization of the food intake pattern, circadian glycemia, and oral glucose tolerance. Additionally, the return to ad libitum feeding restored locomotor activity, although the duration required for its complete recovery warrants further investigation. In conclusion, partial food deprivation induces physio-metabolic changes in rats, most of which are reversed after reestablishing ad libitum feeding.
<P>PROBLEM TO BE SOLVED: To provide a new flavonoid compound having high antioxidizing activity from bamboo grass and/or bamboo leaves as raw material, to provide a method for producing the same, and to provide an antioxidant comprising the same.  <P>SOLUTION: The method comprises the following procedure: From a lower aliphatic alcohol extract liquid from bamboo grass and/or bamboo leaves, the alcohol is evaporated and substituted by water followed by removing chlorophyll and making a liquid/liquid partition with diethyl ether or the like and separating an aqueous layer liquid. Ethyl acetate is added to the aqueous layer liquid to make a liquid/liquid partition followed by separating an ethyl acetate layer liquid. Then, the objective new compound, luteolin 6-C-arabinoside of the chemical formula, is obtained from the aqueous layer or the ethyl acetate layer. By hydrolyzing the lower aliphatic alcohol extract liquid or fractionated liquid, the yield of the objective compound can be improved. In the above chemical formula, Heq and Hax denote equatorial H and axial H, respectively, being signs used for specifying the proton bound to the identical carbon atom of the saccharide.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The utility model relates to a plaster base, which comprises skin material and ointment. The key point is a carrier coated with adhesive. The middle part of the carrier is provided with the skin material bearing the ointment. The outer edge of the skin material is sheathed with an emulsoid ring. The surfaces of the carrier and the skin material are coated thin films. The carrier is provided with air holes. The utility model has the characteristics of firm adhesion, convenient use, good ventilation property, cotton and bandage saving, etc. The utility model is not only suitable for the base used for the ointment and can be also served as the carrier of various kinds of hospital outer dressings.
The investigators aim through the use of proton-transfer-reaction mass spectrometry to perform comprehensive breath analysis to identify compounds of interest associated with glucose fluctuations. More than 500 different volatile organic compounds can be detected in human breath. Compounds such as ethane, pentane and isoprene (hydrocarbons), as well as acetone, acetaldehyde, methanol, ethanol, 2-propanol (oxygen-containing compounds), are most likely to be relevant and measurable in our study population. Hydrocarbons are stable end-products of lipid peroxidation and show only low solubility in blood and therefor are excreted into breath within minutes of their formation in tissues. There is evidence for increased hydrocarbon production in states of oxidative stress. Oxygen-containing compounds such as acetone/acetaldehyde (ketones) are also clinically relevant in the measurement of insulin deficient states of catabolism in patients with diabetes. A previous study of exhaled isoprene was found to be elevated during hypoglycemia. This study aims to expand on this to characterize the full range of changes in concentrations of volatile organic compounds in human breath during glucose fluctuations.

Characterizing this "biochemical fingerprint" of hypoglycemia may provide clues about what so-called diabetes alert dogs are detecting as well as improve our understanding of hypoglycemia, the physiology behind hypoglycemia unawareness, and potentially identify a novel non-invasive measure of blood glucose.
In Cognitive behavioral social skills training (CBSST), skills-based CBT is used to teach individuals how to correct inaccurate dysfunctional thoughts that interfere with goal-directed activities, including defeatist expectancies, low self-efficacy beliefs, and anomalous beliefs. SST focuses on behaviorally-based instruction of interpersonal social skills, utilizing role-modeling, rehearsal, corrective feedback, and positive reinforcement to facilitate learning. In the modified version of CBSST used in this project: 1) we will strengthen the focus on corrective feedback from successful social interactions; 2) focus on normalization and destigmatization of attenuated psychotic symptoms; 3) add motivational interviewing techniques to promote treatment engagement; and 4) use examples and role plays. CBSST will be delivered in three 6-session modules (i.e., Cognitive Skills, Social Skills, and Problem Solving Skills), a total of 18 90-minute group sessions.
Systems and methods for tracking biological samples are presented. In some embodiments, intrinsic and extrinsic biological sample data and/or intrinsic and extrinsic patient data are used to label a biological sample obtained at a point-of-care facility. The labeled biological sample may be sent to a processing facility, wherein the labeled biological sample undergoes analysis and/or processing into a labeled therapeutic. The labeled therapeutic is delivered back to the point-of-care facility, wherein the labeled therapeutic is tested for the presence of the additives prior to administration to a patient. Multi-factor validation is performed, including validating the identity of the patient to a container, validating the identity of the labeled biological sample/therapeutic to the container, and thus, validating the identity of the labeled therapeutic to the patient. The entire life cycle of a biological sample used to generate a personalized therapeutic is validated, and ensures that mix-ups or errors in administration are reduced or eliminated.
The present invention relates to a medicine tablet for treating acute and chronic cholecytitis and cholelithiais and a preparation method thereof, which belongs to the field of medicine and a fabrication technology. The present invention is to solve the technical problems that the medicine tablet which has good curative effect and small medication doses for treating acute and chronic cholecytitis and cholelithiais and the preparation method thereof are provided. The medicine tablet has the technical main point that raw material components comprise 5 to 15 wt% of curcuma root, 15 to 30 wt% of potassium nitrate, 3 to 10 wt% of liquorice, 5 to 15 wt% of figwort, 5 to 15 wt% of alum, 5 to 15 wt% of honeysuckle flower and 30 to 45 wt% of talcum powder. The preparation method comprises that six kinds of medicinal powder of curcuma root, etc. are pulverized into fine powder and matched with talcum powder. The two kinds of powder are sieved, blended, made into particles and pressed into tablets after dryness, and the tablets are coated with sugar coating. The present invention has the efficiency of bacteriostasis, antiinflammation, analgesia, promotion of the function of gallbladder, prevention of lithogenesis. The present invention has good curative effects for acute and chronic cholecystitis, cholelithiasis, renal calculus, etc., and is the relatively ideal new medicine.
Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a “blast flag” in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatment may be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.