anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention comprises nuclearly sulphonated 1 - carboxy - 3 - monocyclic aryl - benzo-[f]-quinolines and their water-soluble salts, which may be prepared by bringing together at an elevated temperature a monocyclic aryl aldehyde, pyruvic acid, and a 2-naphthylamino sulphonic acid in presence of sufficient water to effect ready reaction, and in particular the water-soluble salts of compounds of the formula <FORM:0698995/IV (b)/1> wherein R is hydrogen or benzoyl and X is hydrogen or chlorine. An alkaline agent such as alkali metal or ammonium carbonates or bicarbonates may be present during the preparation.  The compounds are suitable as light filter dyes.  In examples (1) sodium 2-napthylamine-6-sulphonate is reacted with pyruvic acid and salicylaldehyde and the carboxy group of the product converted to its lithium salt with lithium carbonate, or to its ammonium or triethanolamine salts, or the hydroxy group is benzoylated with benzoyl chloride; (2) sodium 2-amino-8-naphthol-6-sulphonate is reacted with pyruvic acid and benzaldehyde or anisaldehyde; (3) 2-amino-5-naphthol-7-sulphonic acid is reacted with benzaldehyde, pyruvic acid and sodium carbonate; (4) sodium 2-naphthylamine-6-sulphonate is reacted with pyruvic acid and benzaldehyde, 2-hydroxy - 5 - chlorbenzaldehyde, anisaldehyde, o-anisaldehyde, or o-chlorbenzaldehyde.ALSO:The invention comprises nuclearly sulphonated 1 - carboxy - 3- monocyclic aryl - benzo(f)-quinolines and their water-soluble salts, which may be prepared by bringing together at an elevated temperature a monocyclic aryl aldehyde, pyruvic acid, and a 2-naphthylamine sulphonic acid in presence of sufficient water, to effect ready reaction and in particular the water-soluble salts of compounds of the formula <FORM:0698995/IV (c)/1> wherein R is hydrogen or benzoyl and X is hydrogen or chlorine. An alkaline agent such as alkali metal or ammonium carbonates or bicarbonates may be present during the preparation.  The compounds are suitable as light filter dyes.  In examples: (1) sodium 2-naphthylamine-6-sulphonate is reacted with pyruvic acid and salicylaldehyde and the carboxy group of the product converted to its lithium salt with lithium carbonate, or to its ammonium or triethanolamine salts, or the hydroxy group is benzoylated with benzoyl chloride; (2) tne sodium 2-amino-8-naphthol-6-sulphonate is reacted with pyruvic acid and benzaldehyde or anisaldehyde; (3) 2-amino-5-naphthol-7-sulphonic acid is reacted with benzaldehyde, pyruvic acid and sodium carbonate; (4) sodium 2 - naphthylamine - 6 - sulphonate is reacted with pyruvic acid and benzaldehyde, 2-hydroxy-5-chlorbenzaldehyde, anisaldehyde, o-anisaldehyde, or o-chlorbenzaldehyde.
Eligible subjects will receive intravenous (IV) infusion of OTL-200 gene therapy. Subjects will also receive conditioning regimen with busulfan.
Radial clamp applied at full pressure for 20 minutes. At the end of 20 minutes, the clamp will be loosened ¼ turn every 5 minutes over 20 minutes and then removed.
Tri-Legest® Fe (norethindrone acetate and ethinyl estradiol tablets, USP and ferrous fumarate tablets [not USP]) is indicated for the prevention of pregnancy in women who elect to use combined oral contraceptives as a method of contraception.

Tri-Legest® Fe is indicated for the treatment of moderate acne vulgaris in females, ≥15 years of age, who have no known contraindications to combined oral contraceptive therapy, desire oral contraception, have achieved menarche, and are unresponsive to topical anti-acne medications. Tri-Legest® Fe should be used for the treatment of acne only if the patient desires a combined oral contraceptive for birth control and plans to stay on it for at least 6 months.

Combined oral contraceptives are highly effective for pregnancy prevention. Table 2 lists the typical accidental pregnancy rates for users of combination oral contraceptives and other methods of contraception. The efficacy of these contraceptive methods, except sterilization, depends upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates.

Norethindrone acetate and ethinyl estradiol tablets were evaluated for the treatment of acne vulgaris in two randomized, double-blind, placebo-controlled, multicenter, Phase 3, six (28-day) cycle studies. A total of 296 patients received norethindrone acetate and ethinyl estradiol tablets and 295 received placebo. Mean age at enrollment for both groups was 24 years. At six months each study demonstrated a statistically significant difference between norethindrone acetate and ethinyl estradiol tablets and placebo for mean change from baseline in lesion counts (see Table 3 and Figure 2). Each study also demonstrated overall treatment success in the investigator’s global evaluation. Patients with severe androgen excess were not studied.

Norethindrone acetate and ethinyl estradiol tablets users who started with about 74 acne lesions had about 42 lesions after 6 months of treatment. Placebo users who started with about 72 acne lesions had about 49 lesions after the same duration of treatment.

Figure 2. Mean Percent Reduction in Total Lesion Counts From Baseline to Each 28-Day Cycle and Mean Total Lesion Counts at Each Cycle Following Administration of Norethindrone acetate and ethinyl estradiol tablets and Placebo (Statistically significant differences were not found in both studies individually until cycle 6)
Participants will also be eligible for $30 at the end of three consecutive 30-day periods ($90 in total) if they submit daily evidence of their medication adherence habit using the Wellth app (i.e. one photo that provides evidence of pill-taking and one photo that provides evidence of their contextual cue, which participants will select and specify on their comprehension survey at the start of the study). Similar to T1, participants will lose $2 (from their $30 total) for every day they miss a check-in with the Wellth app within a 4-hour window around the time of day of their choosing at the start of each 30-day period. Participants will not have to pay money, i.e. they lose $2 per missed check-in from the $30 of incentives until their incentives equal $0. Thus, participants will be ineligible for any financial incentives if they miss more than 15 days in a 30-day period, where this group's check-in includes one photo of pill-taking and one photo of their contextual cue.
The patients was divided into two groups, where one received alcoholization (ethanol lock therapy group) and the other not (control group). The variables evaluated were: CLABSI, etiological agents, adverse events and the mechanical effects of ethanol on the catheter (breakage and obstruction). To determine the association between the independent variable and the dependent variables, the chi-square test of association (Pearson) and Fisher's exact test were used. The Risk Ratio (RR) was calculated as a relative risk measure, with its 95% confidence interval (95% CI). The significance level of 5% was adopted. The sample size calculation was performed in the OpenEpi software version 2.3.1. And a long-term catheter clinical trial was used to calculate the sample size, which demonstrated a 9% central venous catheter infection frequency in the ethanol group and 37% in the control group, so that the sample size was 80 patients (40 in each group), considering a power of 80%, an alpha error of 5% and 10% of post-randomization losses.
Participants will receive 1 oral capsule of omeprazole 40 milligrams (mg) on Day 1 and Day 8. Participants will also receive luliconazole cream 1% to cover the entire affected surface areas and adjacent areas once daily in the morning on Day 2 (24 hours after initial omeprazole dosing) through Day 8.
In this exploratory study we will conduct focus groups and individual interviews with two population segments according to the established methodology of Krueger and Casey \[13\] and Morgan \[14\]. We will conduct 4-6 focus groups, two to three within each population segment, to evaluate the process of decision-making to manage papillary microcarcinoma, factors that influenced decision-making, understanding of risk for recurrence and other negative outcomes due to thyroid cancer, information needed to make informed decisions, and what could influence thyroid cancer patients who have had surgery or have scheduled to have surgery to remove their papillary microcarcinomas to consider active surveillance. Individual interviews will be offered and conducted as needed for those patients who are unable to attend a focus group due to scheduling conflicts or other reasons.
PURPOSE: A composition containing a 4-hydroxy tamoxifen analog for preventing or treating liver diseases is provided to reduce GOT(glutamyl oxaloacetic transaminase) and GPT(glutamyl pyruvate transaminase) level and to prevent and treat liver diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating liver diseases contains a 4-hydroxy tamoxifen analog of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition additionally contains a pharmaceutically acceptable carrier. The liver diseases are non-alcoholic or alcoholic fatty liver. The pharmaceutical composition reduces fat accumulation in the liver. The non-alcoholic fatty liver is non-alcoholic steatohepatitis or late phase fibrosis liver diseases. A food composition for preventing or treating liver diseases contains 4-hydroxy tamoxifen analog of chemical formula 1 or sitologically acceptable salt thereof as an active ingredient.
BACKGROUND: There are gender differences in hypertension and the effect of gender on the relationship between systemic immune-inflammation index (SII) and mortality in hypertensive patients is unclear.
METHODS: Hypertensive patients (n=7444) from ten cycles of the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018 were enrolled in this study. The maximally selected rank statistics method was employed to identify the optimal cut-off value for the SII. Survey-weighted Cox regression analysis was utilized to explore the links between SII and all-cause and cardiovascular mortality. Kaplan-Meier method and time-dependent receiver operating characteristic curve analysis was conducted to assess the predictive accuracy of SII for mortality.
RESULTS: Whether SII was considered as a numerical variable or as a binary variable (higher- and lower-SII groups), higher SII levels were associated with a higher risk of all-cause and cardiovascular mortality in female hypertensive patients (all P < 0.001), but no such association was observed in the males. The area under the curve of the SII was 0.602, 0.595, and 0.569 for 3-, 5-, and 10-year all-cause mortality, respectively, in females, but was 0.572, 0.548, and 0.554 in males. High SII levels interacted with the poverty income ratio and physical activity to affect mortality in the male population (P for interaction < 0.05), and there was an interaction between race and SII in the female cardiovascular mortality rate (P for interaction < 0.05).
CONCLUSION: Higher levels of SII may be closely related to the high risk of all-cause and cardiovascular mortality in hypertensive patients, and the results showed that this relationship is more significant and stable in the female group. High SII interacts with PIR, physical activity, and race to affect the mortality rate in different gender populations.
Obesity is a major and growing problem among U.S. Hispanics with serious implications for diabetes and other chronic disease risks. Current trends among youth suggest that disparities in obesity between minorities and non-Hispanic whites will amplify. Reducing such health disparities is a priority for federal, state and local governmental bodies and communities. Attaining these objectives will require interventions that are culturally- and linguistically appropriate. U.S. healthcare providers, however, have few culturally-appropriate tools and inadequate numbers of bilingual, trained healthcare professionals to address these challenges.

A culturally-appropriate weight-management portal, supported by bilingual Latina dietitians available for remote email counseling, offers an attractive mechanism for efficiently serving the underserved. MiDieta/MyDiet is the leading online diet, fitness and weight management portal for U.S. Hispanic/Latinos. MiDieta is bilingual (Spanish/English), based on Latino foods \& habits and already available through dozens of media, hospital, and health plan websites. Thousands of Hispanics access MiDieta each week. Tommy Thompson recently selected MiDieta as one of the "20 most innovative health promotion and disease prevention applications" in the U.S.
Recognition molecule (I), directed against the gene for human prothrombin (hPT) is new. It interacts specifically with the mRNA of hPT in the target sequence region 489-1932 of NM 000506. An independent claim is also included for pharmaceutical compositions, kits and/or arrays that contain (I). ACTIVITY : Thrombolytic; Anticoagulant; Cardiant; Antiarteriosclerotic; Antiinflammatory; Cerebroprotective; Antianginal; Vasotropic; Hemostatic. MECHANISM OF ACTION : Inhibiting expression of prothrombin. The antisense oligonucleotide agccttcggagcgtggagtc complementary to region 616-635 of the human prothrombin (hPT) gene, was used to transfect Hep-G2 hepatocyte cancer cells. This treatment reduced expression of hPT-specific mRNA to about 30% of that in cells transfected with a nonsense oligonucleotide.
Mycobacterium tuberculosis causing tuberculosis (TB) is a major global public health problem. Because of increasing multi drug resistance and the long treatment period of at least six months, new therapeutic options are urgently needed. In countries like Ethiopia where TB is endemic, chronic worm infection is also highly prevalent. Recent data support that helminth infection might limit the host response against TB by inhibition of the TH1-response that is crucial in controlling the disease. In this study we want to test the hypothesis that Albendazole treatment of patients coinfected with helminths and TB could improve clinical outcome in addition to chemotherapy against TB. Additionally we will investigate the immunological interactions between TB and chronic helminths infection.
To investigate the progress of disparities in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), gonorrhea, and syphilis among children and adolescents aged 6-22 years in China during 2013-2021. A total of 614 325 cases data were extracted from the Chinese Information System for Infectious Diseases Control and Prevention during 2013-2021. Puberty health education data were drew from the Student Health Surveillance in 2021. Disparity patterns and average annual percentage changes (AAPCs) in sexually transmitted infections (STIs) incidence or new cases in China were examined using descriptive statistics and joinpoint regression. The incidence across 345 cities was stratified by gross domestic product (GDP). Between 2013 and 2021, there were 614 325 reported cases of HIV/AIDS, gonorrhea, and syphilis among children and adolescents aged 6-22, with an annual average incidence of 24.0967 per 100 000. The expansion of HIV/AIDS has halted, yet the surge in gonorrhea and syphilis remains notably pronounced. The ratio of male to female AIDS incidence increased from 2.75 (2.60, 2.90) to 7.13 (6.68, 7.62), but that of syphilis changed from 0.33 (0.32, 0.34) to 0.56 (0.55, 0.57). Students and out-of-school individuals aged 13-15 experienced a notably high increase in STI cases, surpassing other age groups, with an average annual percentage increase of 29.2% and 26.3%, respectively. Nonstudents consistently had a higher incidence rate than students, with an IRR reaching 31.80 (31.24, 32.37) in 2021. A noticeable clustering pattern of new cases emerged in the southeastern region of the Heihe-Tengchong line, extending inland from the coastal areas. Districts and counties with lower rates of puberty sexual health education tended to have higher average STI incidence rates. At the prefecture and city levels, there was a noticeable upward trend on average STI incidence rates in cities with per capita GDPs. Strategies to address those disparities include promoting equitable health education, and widespread sexual health education, particularly in areas with limited access to education and experiencing rapid economic development. The effectiveness of sexual health education intervention needs to be further evaluated in well-designed studies.
Lymph node metastasis (LNM) is a major cause of locoregional recurrence of papillary thyroid carcinoma (PTC). However, the mechanisms responsible for LNM are unclear. Aberrant N6-methyladenosine (m6A) RNA modification plays a vital role in cancer progression and metastasis, and whether m6A modification regulates LNM in PTC remains to be determined. This study showed that IGF2BP2 was upregulated in PTC and positively associated with LNM. Functionally, IGF2BP2 knockdown significantly inhibited PTC cell proliferation and invasion in vitro, and vice versa. Moreover, IGF2BP2 knockdown significantly inhibited lymphatic metastasis in vivo. Mechanistically, Human m6A epitranscriptomic microarray, MeRIP, and RIP assays demonstrated that IGF2BP2 activated the NF-KB pathway by enhancing DPP4 stability in an m6A-dependent manner. Furthermore, IGF2BP2 knockdown increased the sensitivity of PTC cells to cisplatin therapy to a certain extent, while its overexpression produced the opposite effects. Overall, this study uncovers that IGF2BP2 promotes lymphatic metastasis via stabilizing DPP4 in an m6A-dependent manner, and provides new insights for understanding the mechanism of lymphatic metastasis in PTC.
A total of 500 cases of pregnant women undergoing cesarean section under spinal anesthesia in Qinghai Red Cross Hospital from February 2022 to September 2022 were selected. General information of the patients were recorded, such as age, height, weight, BMI, nationality, education level, previous history, surgical history, allergy history, spouse status, fertility history and drug use status, and ASA classification was performed. Preliminarily determine whether it meets the inclusion and exclusion criteria. If it can be included in the study, the purpose, method and possible complications of the study should be fully explained to the patients and their families, as well as the significance and value of the study. Informed consent should be signed after the informed consent of the patients and their families. Patients were divided into 5 groups (n=100) according to random number method, including control group (GROUP C) and different concentrations of Esketamine dose group (group E0.2, group E0.4, group E0.6, group E0.8).

Before surgery, the puerpera were fasted for 8 hours and abstained from drinking for 4 hours. After entering the operating room, ECG monitoring and continuous oxygen inhalation by mask (2.0-3.0 L/min) were performed, and the upper limb vein channels were opened. Subarachnoid puncture was performed in L2-3 or L3-4 gaps. After the cerebrospinal fluid flows out, give 0.5% ropivacaine 10-12mg. After the subarachnoid block was successful, the epidural catheter was indurated for 4cm. The supine position was restored, and when necessary, the pregnant women were changed 30° to the left, and the supine hypotension syndrome occurred (SBP≤90mmHg or decrease ≥mmHg), 1-2mg methoxide was injected intravenously. The operation was started after the level of anesthesia was satisfied (maintain anesthesia level\<T6). Postoperative intravenous controlled analgesia (PCIA). The formula of PCIA in different groups.The unified total amount of PCIA is 100mL, the background infusion rate is 2mL /h, the PCA dose is 1ml, the locking time is 20min, and the analgesia lasted until 48h after surgery.

Using SPSS26.0 statistical software. The measurement data is expressed as x±s, the comparison between groups is performed by one-way analysis of variance, the further pairwise comparison is performed by t test, and the comparison of different time points within the group is performed by repeated measures analysis of variance; the comparison of count data is performed by the chi-square test. P\<0.05 indicates that the difference is statistically significant.
PROBLEM TO BE SOLVED: To obtain the subject agent capable of expressing excellent curing effects for sex hormone-dependent diseases such as prostatic cancer or the like by bringing the agent to contain a specific aminobenzimidazole derivative. SOLUTION: This antagonist for gonadotrophic hormone-releasing hormone is a compound expressed by formula I [the ring A is a (substituted)phenyl: the ring B is a (substituted)cyclic group; R4 and R6 are each H, a 2-6 alkenyl or the like; R5 is H, a halogen or the like; X is a direct bond or the like; Y is CO or the like] or its pharmaceutically allowable salt [e.g. 2-(4- methoxyphenyl)-5-(4pyrrolidinobenzoyl)aminobenzimidazole, etc.]. The compound of formula I is obtained, by reacting, e.g. a compound of formula II with a compound of formula III (L1 is an eliminable group). As the dose of the agent, when it is used for preventing or curing sex hormone-dependent diseases, preferably 0.1-approximately 100 mg as the effective ingredient per 1 kg body weight of mammals is administered, usually once or divided into forth times a day.
The Kidney Precision Medicine Project (KPMP) aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies through molecular investigation of human kidney biopsies obtained from participants with AKI or CKD. We present the case of a 66-year-old woman with diabetic kidney disease who underwent a protocol KPMP kidney biopsy. Her clinical history included diabetes mellitus complicated by neuropathy and eye disease, increased insulin resistance, hypertension, albuminuria, and relatively preserved glomerular filtration rate (early CKD stage 3a). The patient's histopathology was consistent with diabetic nephropathy and arterial and arteriolar sclerosis. Three-dimensional, immunofluorescence imaging of the kidney biopsy specimen revealed extensive periglomerular neovascularization that was underestimated by standard histopathologic approaches. Spatial transcriptomics was performed to obtain gene expression signatures at discrete areas of the kidney biopsy. Gene expression in the areas of glomerular neovascularization revealed increased expression of genes involved in angiogenic signaling, proliferation, and survival of endothelial cells, as well as new vessel maturation and stability. This molecular correlation provides additional insights into the development of kidney disease in patients with diabetes and spotlights how novel molecular techniques used by the KPMP can supplement and enrich the histopathologic diagnosis obtained from a kidney biopsy.
PURPOSE:To obtain the title composition providing strong reddish color tone and extremely excellent fastness, comprising 1,5-dihydroxynaphthalene as a coupling substance and 2-amino-5-hydroxybenzoic acid as a developing substance. CONSTITUTION:The title composition comprising 1,5-dihydroxyphthalene and 2-amino-5-hydroxybenzoic acid in a molar ratio of 1:0.8-1:1.5. The composition preferably causes oxidation coupling by adding an oxidizing agent (e.g. H2O2 or H2O2-urea addition product). The composition is blended with a wetting agent (emulsifying agent), a solubilizer, a thickening agent, a stabilizer, a perfume, etc., and preferably provided in a dosage form of cream, emulsion, gel, solution, etc. In dyeing, the composition is blended with an oxidizing agent to give a dyeing solution, which is applied to keratinous fibers for 25-35 minutes to give a color tone having excellent light resistance, washing resistance and wear resistance.