anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a novel compound which is useful as an antimicrobial agent against diseases induced by a variety of pathogenic microorganisms including MRSA because it manifests antimicrobial action to inhibit the proliferation of these microorganisms. CONSTITUTION: A compound of the formula or its salt. This compound is obtained by aerobically culturing a microorganism belonging to Actinoplanes sp. or its mutant (FERM-P-14069) in a medium containing nutrient sources, extracting the culture mixture with a solvent and isolating it by purification. The substance BE-40665D has the following properties: appearance: yellow amorphous solid or crystals; molecular formula: C22 H21 O7 Br; mass spectrography: 477.0549 (calculated value); specific rotatory power: [α]<20> D=-34.0 deg. (c=0.10 in CHCl3 ); solubility: readily soluble in organic solvents such as chloroform, slightly soluble in water; discrimination between acidic, neutral and basic: neutral; color reaction: positive to sulfuric acid reaction.
BACKGROUND: Femoral neck fractures (FNFs) in young adults are usually caused by high-energy trauma, and their treatment remains a challenging issue for orthopedic surgeons. The quality of reduction is considered an important factor in improving the poor prognosis of patients with FNFs. In recent years, positive buttress closed reduction technique has received widespread attention in the treatment of FNFs. This comprehensive literature review is designed to encapsulate the impacts of both non-anatomic and anatomic reduction on the biomechanical stability, clinical outcomes, and postoperative complications in the management of FNFs, conjecture the efficacy of positively braced reduction techniques and provide a thorough summarization of the clinical outcomes.
METHODS: In this literature review, we have examined all clinical and biomechanical studies related to the treatment of FNFs using non-anatomical reduction or positive and negative buttress reduction. PubMed, Web of Science, Google Scholar and Embase Library databases were searched systematically for studies published before September 1, 2023. Published literature on fracture reduction techniques for treating FNFs was reviewed. In addition, we evaluated the included literature using the MINORs tool.
RESULTS: Although the "arch bridge" structure formed by the positive buttress reduction technique improved the support to the cortical bone and provided a more stable biomechanical structure, no significant differences were noted in the clinical efficacy and incidence of postoperative complications between the positive buttress reduction and anatomical reduction.
CONCLUSION: Positive buttress reduction is an effective treatment method for young patients with FNFs. When facing difficult-to-reduce FNF, positive buttress reduction should be considered first, followed by anatomical reduction. However, negative buttress reduction should be avoided.
PURPOSE: To investigate the association between neonatal birthweight (NBW) discordance and preeclampsia (PE) in twin pregnancy.
METHODS: This was a single-center retrospective cohort study. Women with two live births in the First Affiliated Hospital of Sun Yat-sen University from January 2011 to June 2020 were eligible. They were classified into four groups based on the quartiles of NBW discordance in monochorionic (MC) and dichorionic (DC) twin pregnancy. The relationship between NBW discordance and the risk of PE was assessed by logistic regression, subgroup analyses was further analyzed.
RESULTS: A total of 1566 women were eligible for the final analysis, there were 445 MC cases and 1121 DC cases. No matter in monochorionic or dichorionic pregnancy, higher NBW discordance quartiles were associated with increased risks of PE. Compared with women in the lowest NBW discordance quartile, women in the highest NBW discordance quartile had approximately 3.6 and 6.0 times risk of PE in monochorionic and dichorionic pregnancy respectively. The association between quartiles of NBW discordance and the risk of PE were higher in dichorionic pregnancy than in monochorionic pregnancy. No matter in MC or DC pregnancy, no significant interaction effects were identified for maternal age, pregnancy body mass index, mode of conception and whether complicated with gestational diabetes mellitus.
CONCLUSIONS: The increased NBW discordance quartile was related to an increased risk of PE. Assessing estimated fetal weight discordance by using ultrasound in clinical practice to predict PE remained to be further researched.
Cardiac cachexia, the terminal stage of chronic heart failure, is characterized by severe systemic metabolic imbalances and significant weight loss, primarily resulting from skeletal muscle mass depletion. Despite the detrimental consequences, there is no standardized and clinically-approved intervention currently available for cardiac cachexia. In the context of cardiac cachexia, accelerated protein turnover, that is, inhibited protein synthesis and enhanced protein degradation, plays a crucial role in skeletal muscle wasting. This process is primarily mediated by various proteins encoded by atrogenes. Among them, the atrogene Trim63 (tripartite motif family 63) and its encoded protein MuRF1 have been extensively studied. This review article aims to elucidate the pathogenic mechanisms underlying skeletal muscle wasting in cardiac cachexia, describe the biochemical characteristics of MuRF1, and provide an overview of the investigation into MuRF1-targeting inhibitors. The ultimate goal is to offer novel strategies for the clinical treatment for skeletal muscle wasting associated with cardiac cachexia.
PURPOSE:The titled carcinostatic agent, prepared by joining a monoclonal antibody against a human a cancerous antigen produced by a hydridoma to a carcinostatic substance chemically, and capable of inhibiting the growth of cancerous cells by the specific affinity for the human cancerous cells. CONSTITUTION:A carcinostatic agent prepared by chemically joining a monoclonal antibody against the human cancerous antigen produced by a hybridoma, e.g. hydridized cells between splenic cells of animals, e.g. BALB/mice, sensitized with the human malignant melanoma and the myelomatous cells, to a carcinostatic substance (drug), e.g. a basic polypeptide having the cytotoxicity derived from wheat. The bond is obtained by chemically joining the free amino groups or carboxyl groups of the antibody to the amino group, carboxyl group or aldehyde group of the drug to constitute an acid amide, etc. The resultant agent joins to cancerous cells selectively without side effects damagingly affecting the normal cells.
A method comprising exposing tumor cells to ethanol has been found to preserve the tumor cells during storage. As compared to control cells, tumor cells are preserved for a longer time, and retain display of antigen. In a specific embodiment, modified or unmodified cells are exposed to a concentration of about 37.5% (v/v) ethanol for a period of about 10 minutes at about 4 ~C. Methods of storing haptenized tumor cells and vaccine preparations are also provided. It has also been found that tumor cell vaccines which comprise mainly dead or non-Trypan Blue-excluding cells can have retained or even improved antigenicity as compared to live cells. Methods of preparing and using such vaccines are also described.
<P>PROBLEM TO BE SOLVED: To provide a hair tonic capable of promoting epilation by strengthening hair roots and promoting supply of nutrition to hair-mother cells and recovery of a waste material to further enhance action of the hair roots, blackening the hair and thickening the hair, protecting and recovering damaged part of the hair or the scalp and imparting gloss and moisture to the hair and preventing inflammation and drying of the scalp and to provide a method for nursing the hair, capable of carrying out washing of excess sebum and stain, etc., attached to the scalp and raising the temperature of the cell to improve the blood circulation and capable of activating metabolism of the cell, giving mechanical stimulation to the deep layer part of the scalp, promoting production of collagen and enhancing hair growing action and epilation-preventing action of the hair tonic.  <P>SOLUTION: The hair tonic comprises limonene, collagen and an alcohol-based solvent. In the hair tonic, the collagen is preferably contained in an amount of 100-3000 pts. wt. based on 10 pts. wt. limonene.  <P>COPYRIGHT: (C)2004,JPO
The effect of dietary inorganic and organic chromium (Cr) on body morphometry, carcass traits, and nutrient composition, including different minerals and fatty acids in meat and internal organs of Black Bengal goats, was studied. Thirty weaned Black Bengal kids of 3-5 months (5.40 ± 0.34 kg body weight) were assigned randomly into five groups and fed additional Cr for 150 days. The experimental diets comprised a basal diet supplemented with Cr at the rate of 0 (control; without Cr supplementation), 1.0 and 1.5 mg/kg of inorganic Cr (Cr(III)-chloride), and 1.0 and 1.5 mg/kg of organic Cr (Cr-yeast). The body morphometry such as body length, heart girth, paunch girth, loin width, leg circumference, and the carcass traits, namely, slaughter body weight, dressing percentage, hind quarter and forequarter weight, and rib eye area of goats, were not significantly (P < 0.05) changed due to inorganic and organic Cr supplementation. However, organic Cr supplementation (1.0 and 1.5 mg/kg) resulted in a reduction of breast and back fat thickness (P < 0.05) compared with the control group. The weights of internal organs including liver, lungs, spleen, kidney, testes, and heart and their weights as a percentage of slaughter weight were similar (P > 0.05) among different experimental groups. Dry matter, ether extract, and total ash concentrations of muscle and internal organs of Cr-supplemented groups were not affected (P > 0.05) by Cr supplementation. However, crude protein contents in the liver, muscle, kidney, and lungs were greater (P < 0.05) in the organic Cr groups than in the control and inorganic Cr groups. In meat (longissimus dorsi muscle), total saturated fatty acid concentration was lower (P < 0.05; 59.4% versus 55.7%) and the unsaturated fatty acid concentration was greater (P < 0.05; 40.6% versus 44.3%) including palmitoleic acid, heptadecenoic acid, elaidic acid, and arachidonic acid in the organic or inorganic Cr-supplemented groups than in the basal diet group. In conclusion, dietary supplementation of organic Cr in Black Bengal goats has no influence on the carcass traits, but may improve the meat quality with greater protein content, lean, and healthier fatty acids for human consumption.
Provided herein are methods of and computer program products for physical therapy using VR/AR, specifically, for guiding user motion for physiotherapy in VR/AR environments. In various embodiments, a virtual environment is provided to a user via a VR/AR system. An event marker is provided at a first location within the virtual environment. A position of the event marker is adjusted to a second location. Positional data is collected based on the user's interaction with the one or more event markers. The positional data is provided to a remote server via a network and a compliance metric is determined based on the positional data. When the compliance metric differs from a predetermined range, an adjustment is applied to the event marker. In various embodiments, a visual field of a user may be altered and the user guided to repeat a task to assess and/or monitor proprioception.
Swimming induced pulmonary edema (SIPE) is an unusual condition occuring during swimming in cold open water. SIPE is characterized by acute onset of dyspnea and cough, excessive sputum and occasionally hemoptysis. Reversible myocardial dysfunction has been described in swimmers with SIPE and divers with immersion pulmonary edema (IPE). Cardiac dysfunction has also been discussed as a contributing factor triggering SIPE. However, prevalence, severity and prognosis of myocardial dysfunction in patients with SIPE is unknown. Official recommendations for cardiac evaluation of patients after an acute episode of SIPE is lacking.

This case-control-study intends to assess cardiac function in patients with SIPE and in asymptomatic swimmers. We study a large cohort of approximately 12 000 swimmers during Vansbrosimningen, Sweden's biggest annual open water event, with a yearly incidence of SIPE of about 0,4%. Cardiac function is evaluated after swimming as well as at rest by echocardiography, 12-lead electrocardiogram and cardiac biomarkers (Troponin I, NT-pro-BNP).
FIELD: medicine, peptides. SUBSTANCE: invention proposes biologically active compound, tetrapeptide L-alanyl-L-glutamyl-L-asparagyl-L-proline of the general formula: L-Ala-L-Glu-L-Asp-L-Pro, that stimulates functional activity of neurons and pharmacological agent containing effective amount of tetrapeptide of the formula L-alanyl-L-glutamyl-L-asparagyl-L-proline (L-Ala-L-Glu-L-Asp-L-Pro) or its salts as an active component designated for parenteral, intranasal and oral use. Method of stimulation of functional activity of neurons involves prophylactic and/or curative administration to patient pharmacological agent in doses 0.01-100 mcg/kg body mass at least once in a day for time that is necessary to obtain therapeutic effect. Invention can be used as agent stimulating functional activity of neurons in traumas and diseases of nervous system. EFFECT: stimulated functional activity of neurons, normalized metabolism and growth of impaired structures of nervous tissue. 10 cl, 6 tbl, 11 ex
BACKGROUND: Hypoxia disrupts glucose metabolism in hepatocellular carcinoma (HCC). Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) plays an ontogenetic role. Thus, we aimed to explore the regulation of TRPM7 by hypoxia-induced factor (HIF) and its underlying mechanisms in HCC.
METHODS: hypoxia was induced in multiple HCC cells using 1% O2 or CoCl2 treatment, and subsequently blocked using siRNAs targeting HIF-1α or HIF-2α as well as a HIF-1α protein synthesis inhibitor. The levels of HIF-1α and TRPM7 were assessed using quantitative PCR (qPCR) and Western blot analysis. Chromatin immunoprecipitation (ChIP) and luciferase assays were performed to observe the regulation of TRPM7 promoter regions by HIF-1α. A PCR array was utilized to screen glucose metabolism-related enzymes in HEK293 cells overexpressing TRPM7 induced by tetracycline, and then verified in TRPM7-overexpressed huh7 cells. Finally, CCK-8, transwell, scratch and tumor formation experiments in nude mice were conducted to examine the effect of TRPM7 on proliferation and metastasis in HCC.
RESULTS: Exposure to hypoxia led to increase the levels of TRPM7 and HIF-1α in HCC cells, which were inhibited by HIF-1α siRNA or enhanced by HIF-1α overexpression. HIF-1α directly bound to two hypoxia response elements (HREs) in the TRPM7 promoter. Several glycolytic metabolism-related enzymes, were simultaneously upregulated in HEK293 and huh7 cells overexpressing TRPM7 during hypoxia. In vitro and in vivo experiments demonstrated that TRPM7 promoted the proliferation and metastasis of HCC cells.
CONCLUSIONS: TRPM7 was directly transcriptionally regulated by HIF-1α, leading to glycolytic metabolic reprogramming and the promotion of HCC proliferation and metastasis in vitro and in vivo. Our findings suggest that TRPM7 might be a potential diagnostic indicator and therapeutic target for HCC.
Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and constitutes a central pathophysiological process that underlies tissue dysfunction, across organs, in multiple chronic diseases and during aging. Myocardial fibrosis is a key contributor to dysfunction and failure in numerous diseases of the heart and is a strong predictor of poor clinical outcome and mortality. The excess structural and matricellular ECM proteins deposited by cardiac fibroblasts, is found between cardiomyocytes (interstitial fibrosis), in focal areas where cardiomyocytes have died (replacement fibrosis), and around vessels (perivascular fibrosis). Although myocardial fibrosis has important clinical prognostic value, access to cardiac tissue biopsies for histological evaluation is limited. Despite challenges with sensitivity and specificity, cardiac magnetic resonance imaging (CMR) is the most applicable diagnostic tool in the clinic, and the scientific community is currently actively searching for blood biomarkers reflecting myocardial fibrosis, to complement the imaging techniques. The lack of mechanistic insights into specific pro- and anti-fibrotic molecular pathways has hampered the development of effective treatments to prevent or reverse myocardial fibrosis. Development and implementation of anti-fibrotic therapies is expected to improve patient outcomes and is an urgent medical need. Here, we discuss the importance of the ECM in the heart, the central role of fibrosis in heart disease, and mechanistic pathways likely to impact clinical practice with regards to diagnostics of myocardial fibrosis, risk stratification of patients, and anti-fibrotic therapy.
The CT-AMT-011-01 study is an open-label, dose-escalating study evaluating the safety and efficacy of a single intramuscular administration of AMT-011 (at multiple sites). The study will be performed in the Community Genomic medicineCenter (CGMC) Chicoutimi, Canada, under the supervision of their medical ethical committee and according to the local biosafety procedures. The study participants will be treated under the responsibility of a Principal Investigator specialised in the treatment of lipid disorders. A total number of 14 subjects will be administered. Participants will be screened 3 weeks prior to administration of AMT-011 and will be evaluated for 12 weeks post administration in this study. After the study, subjects will be followed up long term with particular emphasis on the safety and efficacy aspects of LPL gene therapy using AMT-011. Subjects will be evaluated at the clinical site at 19 weeks, 26 weeks, 39 weeks, 1 year, 1.5 years, 2 years, 3 years, 4 years and 5 years after administration of AMT-011. The TG values that are obtained at week 26 will be used for secondary efficacy analysis.
Introduction: Avascular necrosis is a debilitating osseous complication in transplant recipients. Project Aim: This program evaluation sought to describe risk factors and adverse outcomes of avascular necrosis in kidney transplant recipients. Design: This was a retrospective evaluation of all recipients of kidneys and simultaneous pancreas and kidneys between 2001 and 2018 from a single center. Controls were selected based on the incidence density, sampling at a 1:3 ratio based on the post-transplant interval. Outcomes of interest were acute rejection, death-censored graft failure, and patient mortality. Results: A total of 88 kidney recipients had avascular necrosis and were compared with 257 controls. Most of the recipient's and donors' baseline characteristics were similar between the groups, except calcineurin inhibitor-based immunosuppression was more prevalent, and non-white donors were less prevalent in the control group. Looking for risk factors for avascular necrosis, calcineurin inhibitor-based immunosuppression was associated with a lower risk for avascular necrosis in the univariate analysis, but this was not found after adjustment of multiple variables. In multivariate analysis, avascular necrosis was associated with an increased risk for patient death (hazard ratio: 1.68; 95% confidence interval: 1.16-2.44; P = .008) but not for acute rejection or death censored graft failure. Conclusion: Although limited by small sample size, this evaluation found avascular necrosis to be associated with an increased risk of patient death. This finding may be useful for the provider taking care of the patients and discussing the various outcomes after the transplant.
A medical consultation system comprises one or more activation devices for issue to a user, the activation device comprising a memory component. The system also comprises a medical consultation device having a user interface, a device reader 9 for reading information to and receiving information from the activation device. The medical consultation device connects to an electronic health records platform over a communications network and collects medical data from the user preferably from a plurality of sensors. The medical consultation device checks for a connection to the electronic health records platform and if the connection is available uploads the medical data to the electronic health records platform. The medical consultation device is preferably solar powered and preferably has two antennae, one directional and one omnidirectional. Also claimed is a corresponding method of conducting a medical consultation.
OBJECTIVE: Neuropathy of the lateral cutaneous branch of the iliohypogastric nerve (LCBIN) may represent a differential diagnosis for greater trochanteric pain syndrome (GTPS). Ultrasound-guided neural blockade of the LCBIN may lead to diagnosis of this neuropathy. The aim of this study was to evaluate the accuracy of ultrasound-guided nerve block in cadavers and to present a first clinical case series of patients with neuropathy of the LCBIN where the workup for GTPS remained unremarkable. Ultrasound-guided nerve block led to pain relief in these patients, indicating LCBIN neuropathy.
METHODS: First, ultrasound-guided injections at the LCBIN were performed bilaterally in 24 fresh, non-frozen, non-embalmed body donors. Accuracy and nerve localization were validated by anatomic dissection. Second, a clinical case series of nine patients with suspected GTPS who underwent ultrasound-guided diagnostic LCBIN blockade was retrospectively analyzed.
RESULTS: Ultrasound-guided injections at the LCBIN yielded 91.7% accuracy (95% confidence interval: 0.80-0.98). On the right side the nerve was found within a range of 3-14 cm from the anterior superior iliac spine, and within a range of 7-15 cm on the left side. This clinical case series indicates that ultrasound-guided blockade at the LCBIN provides temporary pain relief and indicates the presence of LCBIN neuropathy.
CONCLUSION: Ultrasound has demonstrated high accuracy for localization and injection guidance in the examination of LCBIN. Ultrasound-guided injection of local anesthetics may help to identify LCBIN neuropathy as a differential diagnosis in patients with suspected GTPS.
INCB059872 1 mg tablet administered orally QOD for 28 days on an empty stomach. If dose was well tolerated, QD administration was evaluated independently and in parallel with QOD administration.
PURPOSE:To provide a compsn. improved in the long-term color stability of drugs, cosmetics, foods, etc. colored therewith, by blending a shikonin pigment with tannin. CONSTITUTION:A shikonin pigment, which is contained in the root, etc. of gromwell of Boraginaceae vegetables, is blended with tannin (pref. one extracted from cranesbill) to provide a stable compsn. The blending ratio of tannin to the shikonin pigment is pref. around 1:1 in terms of molecular weight ratio in most cases. The obtd. shikonin pigment compsn. retains its vivid purplish red color as blended without being affected by light, air and humidity.