anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a natural-plant-ingredient-containing wash-free wet tissue capable of being used for mildly and effectively cleansing the face. The wet tissue consists of non-woven fabrics and cleansing liquid, wherein the cleansing liquid consists of oil-based cleansing liquid, surfactants, natural plant extracts, polyol humectants, preservatives and water. The natural plant extracts are one or several kinds of materials from witch hazel extracts, rose extracts, calendula extracts, lavender extracts, aloe extracts, coptis chinensis extracts and avocado extracts. The natural plant source and core technology compounded grease can be used for dissolving various oil-based cosmetics, and is particularly effective for eye shadow and eyeliners. The mild surfactants can be used for clearing various kinds of dirt, and can be used for maintaining the sin smoothness; the natural plant extracts can be used for smoothening and moistening the skin; the skin with cosmetic allergies can be relieved and restored; the skin can become dry fast through the addition of polyol. After the natural-plant-ingredient-containing wash-free wet tissue is used by many experimenters, the result shows that the wet tissue can be used for effectively cleansing the face; the use is convenient; the moisture preservation and restoration functions are good.
After admission to the ICU, before the coiling / clipping intervention has been performed, the patients are screened for eligibility. When the patients are coming back to the ICU, after successful aneurysm coiling or clipping, data of artificial ventilation, systemic and other cerebral parameters will be collected continuously by online monitoring, starting at baseline and stopping at discharge of the ICU. Sevoflurane will be vaporized and administrated by the MIRUS™System directly to the inspiratory part of the ventilation circuit for the next 4 hours. In the following 14 days of the stay on the ICU, standard monitoring parameters, the appearance of vasospasm and brain oedema will be recorded. Besides the continuous online monitoring, laboratory assessment will be performed daily. At day 7±2 and day 14±2 after bleeding a MRI or CT examination will be performed, according to the clinical condition of the patient, to detect secondary brain injuries, as ischemia or brain oedema. At ICU discharge, the neurological outcome will be assesses applying GOS.
Caspase-11 is the murine homologue of human caspases-4 and -5 and is involved in mediating the inflammatory response. However, its functions are often confused and misinterpreted with the more important and better described caspase-1. Therefore, this study focused exclusively on the specific roles of caspase-11, both in cartilage formation and in the inflammatory environment. The presence of caspase-11 during mouse limb development and in chondrogenic cell cultures was investigated by immunofluorescence detection. Subsequently, the function of caspase-11 was downregulated and the affected molecules investigated. The expression analysis applied for osteo/chondrogenesis associated factors and inflammatory cytokines. Simultaneously, morphological appearance of the micromass cultures was evaluated. The results revealed that caspase-11 is physiologically present during cartilage development, but its inhibition under physiological conditions has no significant effect on chondrogenic differentiation. However, in an inflammatory environment, inhibition and downregulation of caspase-11 leads to reduced differentiation of cartilage nodules. Additionally, reduced expression of several genes including Col2a1 and Sp7 and conversely increased expression of Mmp9 were observed. In the cytokine expression panel, a significant decrease was found in molecules that, along with the inflammatory function, may also be involved in cartilage differentiation. The findings bring new information about caspase-11 in chondrogenesis and show that its downregulation under inflammatory conditions reduces cartilage formation.
Systems and methods for distributing pharmaceutical product information. The system includes a transmitter device and a receiver device. The transmitter device includes a first electronic processor and first communications interface communicatively connected to both of a barcode scanner and to a first electronic communications device. The receiver device includes a second electronic processor and a second communications interface communicatively connected to a second electronic communications device. The first electronic processor is configured to receive from the barcode scanner, via the first communications interface, scanned product information of a product, and transmit the scanned product information to the receiver device. The second electronic processor is configured to receive the scanned product information, determine, from the scanned product information, a subset of product information relevant to a software application of the second electronic communications device, and transmit, to the second electronic communications device, the subset of product information.
This arm receives the A-TEAM approach where the men, their social support (if they have one), and their case manager participate. If the adherence device identifies non-opening of the device, the men are alerted by text or email the same day. If the device identifies non-opening of the device two days in a row, the social support (or case manager) is notified, and if 7 days of non-opening is detected, the case manager is notified.
The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol-disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients' sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol-disulfide homeostasis and ischaemia-modified albumin were measured.<br> We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol-disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol-disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol-disulfide homeostasis in multiple sclerosis patients.
A system and method for managing information is disclosed. The method may include configuring a list of patients based on specified criteria and accessing patient data for a specific patient from the list of patients. The list of patients may include the name of at least one patient and various information associated with the patient, for example a status indicator and/or an alert indicator. Additionally, the name of a patient may be classified as confidential. The patients classified as confidential may be assigned an alias name to be displayed in the list of patients in place of the real name of the patient. The identity of a user may be associated with user permissions. The method may also include selecting a mode of operation based on a connection speed. The step of selecting may be performed by a user or by computer software.
PURPOSE:To obtain a photocurable dental resin composition having fast curability, and giving photocured products essentially excellent in the water resistance, strength and hardness and substantially equal to thermally cured products. CONSTITUTION:This photocurable dental resin composition contains an acrylic/ methacrylic acid mixture ester of formula I [R<1>, R<2> are a (substituted) 2-12C aliphatic hydrocarbon; R<3> is O-CO-NH, NH-CO-O] as a polymerizable component. This ester is compound having an acryloyl group and a methacryloyl group in the molecule and further having a urethane bond. Since the ester is the acrylic/methacrylic acid mixture ester, the ester is excellent in photocurability and gives cured products highly excellent in strength and hardness when cured with visible light. The ester of formula I wherein R<3> is O-CO-NH can easily be shnthesized e.g. by the urethane-forming reaction of an NCO-having acrylic or methacrylic acid with an OH-having methacrylic or an acrylic acid ester.
Respiratory muscle training: Inspiratory General Training (30 minutes in cycle ergometer) and high intensity inspiratory muscle training: The inspiratory training was conducted with the Orygen® valve. Inspiratory training load was defined as maximum and patient tolerance that would perform 10 consecutive inspirations (5 series) two times a day, during 3 weeks.
Chronic renal failure is serial clinical manifestations because of kidney damage. Previous studies found sympathetic nerves over activity in chronic renal failure patients. Traditional therapies included medications and dialysis replacement therapy need to spend much money. Renal ablation for sympathetic modification is a new method which is proved to be effective in decreasing sympathetic nerves activity. We assume that modifying renal sympathetic activity by ablation is effective and safe in treatment of chronic renal failure. This trial is going to recruit 200 patients (Ablation group VS Control group = 1:1) with a follow-up duration of 3 years. Patients in ablation group will receive additional necessary medications besides expectant intervention, and patients in control group will receive appropriate medications only. We aim to observe the effect of serum creatinine, creatinine clearance rate, glomerular filtration rate, urine microalbumin, urine microalbumin/creatinine, and composite cardio cerebrovascular events after renal sympathetic modification using THERMOCOOL® catheter, and evaluate safety and efficacy of the intervention.
According to the USDA Economic Research Service Food Availability Data, beef consumption has been on a general decline for the past 40 years, with current per capita consumption approximately 35% lower in 2020 than in 1980. Some of this decline over the past few years can be attributed to politically motivated claims that carbon emissions from cattle represent a major threat to the global environment. However, the major reason for declining beef consumption is the widely promulgated claim that beef is unhealthy. The hamburger in particular has become a poster child for the notion that beef consumption is responsible for the increasing occurrence of obesity in the United States. The trend of decreasing beef consumption due to perceived health concerns, particularly obesity and associated health problems, has led major fast-food chains such as Burger King and McDonalds, to offer vegetarian burgers as healthy alternatives to the traditional beef burger. However, examination of the components of the macronutrient matrix of a typical vegetarian burger gives reason to question the health benefits as compared to a traditional beef patty-hamburger.
Patients with treated aortic isthmus stenosis during their first year of life often develop a Recoarctatio Aortae (re-stenosis of the aortic isthmus) in the long term followed by arterial hypertension. The Recoarctatio Aortae can be treated during a cather intervention by balloon dilatation or stent implantation. Patients with arterial hypertension often develop vascular remodeling with increased central systolic blood pressure and increased pulse pressure. Vascular remodling predics cardiovascular events and increases mortality. Vascular remodeling can be assessed non-invasively by using scanning laser doppler flowmetry (SLDF)), pulse wave analysis and measurement of flow-dependent vasodilation. In this controlled clinical study we investigate arterial blood pressure and vascular remodling before and 4 weeks after catheter interventional treatment of Recoarctatio Aortae.
The invention relates to a multispecific nanobodues chimeric antigen receptor and T-cell engager, a nucleic acid, an expressing cell the same, a use thereof and a pharmaceutical composition for treating cancer. The multispecific nanobodues chimeric antigen receptor and T-cell engager includes a HLA-G nanobody chimeric antigen receptor and a bispecific T-cell engager. The HLA-G nanobody chimeric antigen receptor includes a HLA-G nanobodies unit, a transmembrane domain, and a CD3z signaling domain. The bispecific T-cell engager includes a PD-L1 nanobodies unit and a CD3e nanobody. The multispecific nanobodues chimeric antigen receptor and T-cell engager can induce tumor cell death and have excellent tumor growth inhibitory effect. Therefore, the multispecific nanobodues chimeric antigen receptor and T-cell engager can be used to prepare a drug for inducing the death of a tumor cell in mammals and as a pharmaceutical composition for treating cancer.
PROBLEM TO BE SOLVED: To obtain the subject medicine taste-masked with a little amount of covering and so having only a little changed elusion rate by covering the surface of the medicine with an aqueous coating liquid containing spherical solid particles comprising ethyl cellulose as the main ingredient and having a specified diameter and an elusion control agent. SOLUTION: This medicine is obtained by covering the surface of the medicine with an aqueous coating liquid containing (A) spherical solid particles having <=1 μm diameter and comprising ethyl cellulose of preferably 41.0-51.0 wt.% ethoxy group containing rate as the main ingredient, (B) a plasticizer (e.g. acetylated monoglyceride) and (C) an elusion control agent (e.g. methyl cellulose) preferably by a method using a fluidized bed-type coating apparatus or the like. The compounding ratio is preferably 0.05-0.50 component B and 0.01-1.0 component C per the component A. The coating ratio is 3-30 wt.% based on the medicine.
Sensory integration required for balance will be measured using the sensory organization test which includes six conditions in which visual and proprioceptive sensory cues are sequentially referenced (i.e. reduced) to stress available sensory information and sensory integration for postural control. Performance on the sensory organization test has been correlated with falls and successful response to balance perturbation.Balance performance will be evaluated by postural sway. Cognitive function will be assessed using the NIH toolbox with a focus on executive function. tDCS will be used to modify PFC excitability and measure its immediate after-effect on balance performance while performing the sensory organization test in OTTBCS. CIPN severity will be evaluated using measurements of distal proprioception.The study sample will be older breast cancer survivors (n=20) diagnosed and treated with taxane chemotherapy after the age of 60 years to avoid heterogeneity due to multiple cancer types, treatments, and sexes.
This group receives the Fitbit Zip, and access to the Fitbit website. Fitbit Zip counts the number of steps walked, calories burned, and distance travelled. Participants can set goals for their physical activity levels, and will have access to personalised feedback from Fitbit. This group will also receive $4 per week, regardless of physical activity levels.
The invention provides an injectable drug combination and a preparation method thereof. The injection preparation which is a freeze-dried powder injection comprises salvianolic acid B and a pharmacologically allowable pH regulator, without other excipients. The addition of the pH regulator is pH being 4-5 in the pre-freeze drying system. The salvianolic acid B injection preparation provided by the invention selects a proper pH range without the addition of a supporting agent to ensure the stabilization of the injection as well as the pharmacological acceptability of the injection. The invention has advantages of safe clinical use, no bad effect of inducing hemolysis, good safety and stable quality for long-term storage with the stability and safety completely meeting the requirement of the injection preparation and the requirement of clinical application. The injection prepared by the technology needs no addition of auxiliary materials such as a stabilizer, a freeze-drying excipient and so on and the hidden danger of the injection is decreased. The invention avoids the use of magnesium salt and the side effect of magnesium ion to cardiovascular system can be prevented.
Regional anaesthesia (RA) for arteriovenous grafting surgery has advantages of avoiding risks of general anaesthesia (GA) in this group of patients with significant co-morbidities, and beneficial vasodilatation, which may prevent early fistula thrombosis. Hence, RA is preferable to GA for this surgery.

Brachial plexus blocks (BPB) are the most commonly employed RA technique to anaesthetise the upper limb for this surgery. According to the results of a recent 2-year retrospective audit in our centre, ultrasound-guided supraclavicular BPB are the most popular RA technique for this surgery. Anatomically, the T1 and T2 dermatomes are often missed by the supraclavicular BPB. This means that the upper medial arm and axilla (sites involved in brachiobasilic and brachioaxillary arteriovenous grafting) may not be adequately anaesthetised, mandating intraoperative local anaesthetic supplementation by the surgeon. This may affect patients' and surgeons' acceptance of, and satisfaction with the RA technique. The ultrasound-guided Pecs II block, described by Blanco et al, seems to address this problem, as the intercostal T1-6, intercostobrachialis, long thoracic nerves and nerve to serratus anterior are targeted by this block.
The invention discloses a formula used for treating insomnia. The formula comprises medicinal herbs of: 20g of tuber fleeceflower root, 12g of spine date seed, 6g of thinleaf milkwort root, 12g of desertliving cistanche herb, 20g of upright ladybell root and pilose asiabell root, 12g of chinese arborvilae seed, 6g of albizzia julibrissin, and 12g of American ginseng. The medicinal herbs are boiled in a medicine pot with a big fire, and are stewed for 30min by with a mild fire; the temperature of the medicine liquid is reduced until the medicine liquid is warm; the medicine liquid is orally taken. The medicine liquid of each preparation is separated into two parts, and is taken twice a day. One part is taken at approximately 10 o'clock in the morning, and another is taken at 8 o'clock in the evening after supper. The medicine is taken 5 times in a treatment course, and is taken for at least 3 treatment courses. The formula provides functions of sedating and tranquilizing. The medicine provides a sleep-promoting effect for people with insomnia.
Daunorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action. Daunorubicin forms complexes with DNA by intercalation between base pairs. It inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes. Single strand and double strand DNA breaks result. 

Daunorubicin hydrochloride may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA.

Daunorubicin hydrochloride possesses an antitumor effect against a wide spectrum of animal tumors, either grafted or spontaneous.
The needle entry points of the lower row are straight punctures that penetrate the muscle attachments along the medial superior margin of the posterior superior iliac spine, the medial margin of the sacroiliac joint, and a portion of the lateral iliac crest of the lumbar triangle. The entry point of the upper row of needles was made oblique, and then small lifting insertion, respectively, reached and penetrated the anterior border muscle attachments. Then subperiosteal stabbing along the bone surface was used to penetrate 1.5cm forward and downward, and the needle was retained for 15min. The needle was left in place for 15 min, and for the second puncture, the entry point was chosen to be in the middle of the two longitudinal entry points of the first puncture. The rest of the operation was unchanged. Repeat the above operation for the last 3 treatments. The treatment is performed twice a week for a total of 5 treatments.
Study design The PACUS Trial was a single center, single blinded, randomized trial designed to evaluate the safety and efficacy of intravascular percutaneous catheter-delivered high intensity, low-frequency ultrasound utilizing CardioProlific Genesis™ System to improve local paclitaxel delivery effect in patients with CLI due to femoral-popliteal calcific lesions and occlusions. The protocol was approved by a Local Review Boards and the Institutional Ethics Committee. All patients provided written informed consent before enrollment. The trial was conducted in accordance with the declaration of Helsinki.

Randomization Randomization occurred after successful crossing and pre-dilatation of the target lesion with a standard percutaneous angioplasty balloon without sub-intimal approach and/or flow limiting dissections. Patients were enrolled when a successful angiographic control was performed after PTA pre-dilatation. Subjects were randomly assigned by a computer-generated random sequence (2 blocks in a 1:1 ratio). Randomization was done in advance for all patients and without any stratification. The patients and physicians involved in the follow-up control were blinded to the treatment assignments through the completion of all 6 month follow-up evaluation. Operators were not blinded due to differences in treatment protocol. Twenty eight (28) patients were treated with an intravascular percutaneous catheter-delivered high intensity, low-frequency ultrasound and local Paclitaxel delivery with temporarily blood flow occlusion created by distal occlusion balloon (Study Group), and twenty eight (28) patients were treated with drug eluting balloon with conventional method (Control Group).