anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obstructive sleep apnea (OSA) and obesity are highly prevalent and bidirectionally associated. OSA is underrecognized, however, particularly in women. By mechanisms that overlap with those of obesity, OSA increases the risk of developing, or having poor outcomes from, comorbid chronic disorders and impairs quality of life. Using 2 illustrative cases, we discuss the relationships between OSA and obesity with type 2 diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, and reproductive disorders. The differences in OSA between men and women, the phenotypic variability of OSA, and comorbid sleep disorders are highlighted. When the probability of OSA is high due to consistent symptoms, comorbidities, or both, a diagnostic sleep study is advisable. Continuous positive airway pressure or mandibular advancement splints improve symptoms. Benefits for comorbidities are variable depending on nightly duration of use. By contrast, weight loss and optimization of lifestyle behaviors are consistently beneficial.
Exposure and Response Prevention Structured protocol described by Foa et al., 2012 Patients will attend eight 1-h sessions,once a week. Benzodiazepine will be used when necessary.
PURPOSE:To fix a high-quality extract in the raw which is not degenerated with high efficiency by rapidly depressurizing the supercritical gaseous carbon dioxide contg. the extract to transform the extract into a solid, and fixing the extract. CONSTITUTION:The supercritical gaseous carbon dioxide introduced in a separation vessel 2 is rapidly depressurized, and cooled to a low temp. of -56.6--79 deg.C by the adiabatic expansion, and a significant amt. of the supercritical gaseous carbon dioxide is transformed into a powdery snow-shaped solid carbon dioxide. The extract contained in the supercritical gaseous carbon dioxide is mostly adsorbed on the solid carbon dioxide, and occuluded therein. As a result, the extract contained in the supercritical gaseous carbon dioxide is fixed without being heated, and hence the high-quality extract in the raw which is not degenerated can be fixed as such with high efficiency.
All participants will then be introduced to an analgesia expectation: "This cream is a powerful pain killer", while receiving an inert cream. In this study participants will be told that they will receive a potent painkiller as well as a control cream. Making use of placebo cream is an established method to induce placebo expectations . Moreover, to increase the analgesic effect, heat pain stimuli intensity will be surreptitiously lowered for the placebo trials to a temperature corresponding to 30% of the VAS intensity and to 60% for the control trials. As the occurrence of a placebo response is highly dependent on expectations, the deceptive procedure described above is used in order to maximally enhance expectations and therefore placebo response. Participants will be debriefed after the completion of study participation.
Described herein are systems and methods for automated completion, combination, and completion by combination of sinograms. In certain embodiments, sinogram completion is based on a photographic (e.g. spectral or optical) acquisition and a CT acquisition (e.g., micro CT). In other embodiments, sinogram completion is based on two CT acquisitions. The sinogram to be completed may be truncated due to a detector crop (e.g., a center-based crop or an offset based crop). The sinogram to be completed may be truncated due to a subvolume crop (e.g., based on low resolution image projected onto sinogram).
This is a Phase 1, open- label, non- randomized, uncontrolled, single dose pilot study to evaluate the safety, tolerability and efficacy of a single intravenous infusion of BBM-H901 in hemophilia B subjects with ≤2IU/dl residual FIX levels and aged 12-18 years old. BBM-H901 is an adeno-associated viral (AAV) vector designed to drive expression of the human factor IX (hFIX) transgene and raise circulating levels of endogenous FIX. Nine subjects will be enrolled and administered with single infusion of BBM-H901, an AAV at one dose level of 5x10'12 vg/Kg. Subjects and statutory guardian must provide informed consent and then undergo screening assessments up to 4-8weeks prior administration of BBM-H901. All subjects will undergo 52(+- 2) weeks safety observation and will be continuously followed up to evaluate long- term safety and efficacy of BBM-H901 up to ten years. The first subject will be dosed at 5x10'12 vg/Kg and undergo 8 weeks safety observation of which the data will undergo review by an independent safety committee.
<P>PROBLEM TO BE SOLVED: To provide particulate-including composite tubular basic magnesium carbonate with new shape and form in which other particulates are fixed to the inside, to provide its production method, and to provide a composition and a structure comprising the same.  <P>SOLUTION: In the process where the columnar particles of magnesium orthocarbonate are produced, and then, basic magnesium carbonate consisting of tubular flocculated particles is produced, one or more kinds of particulates are mixed by addition or the like, so that the particulate-including composite tubular basic magnesium carbonate in which particulates are fixed to the insides of the tubular flocculated particles is produced. The produced particulate-including composite tubular basic magnesium carbonate has a peculiar form characterized by the tubular flocculated particles consisting of thin piece-shaped fine crystals, and exhibits various excellent characteristics such as a high specific surface area, high pore volume, high oil absorbability, high water absorbability and low bulk density derived from the peculiar form. It also has the characteristics of the included particulates. Further, since the tubular flocculated particles of basic magnesium carbonate and the particulates are compounded in a peculiar form, their demerits are mutually complemented, or the appearance of new characteristics or functionality can be expected by the compositing.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
1-Alkanones substd. in 1-position with an aromatic gp. and optically active, of formula (I), (in which Ar is an aromatic gp., R is a satd. aliphatic gp., X is a halogen atom or sulphonyloxy gp., and C asterish is an asymmetric C atom) are made by reacting an alkanoic acid halide, optically active, of formula (II) (in which Y is a halogen atom, R, X and asterish are as above) with an aromatic cpd. of formula Ar-H, (in which Ar is as above) in presence of Lewis acid. - They are of pharmaceutical and agricultural use.
Increased Mortality— Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Olanzapine is not approved for the treatment of patients with dementia-related psychosis [see Boxed Warning, Use in Specific  
Populations (8.5), and Patient Counseling Information (17)].

In placebo-controlled clinical trials of elderly patients with dementia-related psychosis, the incidence of death in olanzapine-treated patients was significantly greater than placebo-treated patients (3.5% vs 1.5%, respectively). 

Cerebrovascular Adverse Events (CVAE), Including Stroke — Cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, were reported in patients in trials of olanzapine in elderly patients with dementia-related psychosis. In placebo-controlled trials, there was a significantly higher incidence of cerebrovascular adverse events in patients treated with olanzapine compared to patients treated with placebo. Olanzapine is not approved for the treatment of patients with dementia-related psychosis [see Boxed Warning and Patient Counseling Information (17)].
Circulating tumor cells (CTCs) serve as important biomarkers in the liquid biopsy of hepatocellular carcinoma (HCC). Herein, a homogeneous dual fluorescence indicators aptasensing strategy is described for CTCs in HCC, with the core assistance of a steric hindrance-mediated enzymatic reaction. CTCs in the sample could specifically bind to a 5'-biotin-modified glypican-3 (GPC3) aptamer and remove the steric hindrance formed by the biotin-streptavidin system. This influences the efficiency of the terminal deoxynucleotidyl transferase enzymatic reaction. Then, methylene blue (MB) was introduced to react with the main product poly cytosine (polyC) chain, and trivalent cerium ion (Ce3+) was added to react with the byproduct pyrophosphate to form fluorescent pyrophosphate cerium coordination polymeric nanoparticles. Finally, the CTCs were quantified by dual fluorescence indicators analysis. Under optimized conditions, the linear range was 5 to 104 cells/mL, and the limits of detection reached 2 cells/mL. Then, 40 clinical samples (15 healthy and 25 HCC patients) were analyzed. The receiver operating characteristic curve analysis revealed an area under the curve of 0.96, a sensitivity of 92%, and a specificity of 100%. Therefore, this study established a sensitive and accurate CTCs sensing system for clinical HCC patients, promoting early tumor diagnosis.
PURPOSE:To produce a new compound low in stimulation to the eye, having a satisfactory intraoculara pressure reducing effect in a low concentration and useful for prevention and therapy of glaucoma. CONSTITUTION:A compound of formula I (R<1> is H or nsopropyl), e.g. 13,14- dihydroprostaglandin F2beta isopropyl ester. This compound of formula I is synthesized by hydrolyzing a compound of formula II (THP is tetrahydropyran-2-yl; TBDMS is t-butyldimethylsilyl) under an acidic condition, e.g. using acetic acid, in a solvent such as THF at 0 to 90 deg.C. An intraoculara pressure reducing effect is quickly manifested and the effect is continued. Side effects such as initial increase of intraoculara pressure are low.
It is planned to include volunteer patients who came to Van YYU Faculty of Dentistry, Oral and Maxillofacial Radiology Department between February and March 2022 for routine examination. Patients who applied to Yüzüncü Yıl University Faculty of Dentistry for treatment and met the study criteria will be included in the study by signing an informed consent form. 40 patients diagnosed with chronic apical periodontitis and having teeth with radiographic periapical lesions will be included in the study. Patients with periodontitis will not be included in the study.

GCF samples will be taken from the teeth diagnosed with chronic apical periodontitis and the contralateral teeth (from healthy teeth). The tooth which is resource of GCF will be isolated with cotton pellets. After the supragingival plaque is carefully removed with a curette, the tooth will be air-dried for 10 seconds, and periopaper strips will be placed in the gingival sulcus until resistance is felt. Periopaper strips will be removed from the gilgival sulcus after 1 minute. The levels of IL-17, TNF-alpha and RANKL from the samples in the gingival crevicular fluid will be evaluated.
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing, affecting over one-third of the global population and contributing to significant morbidity and mortality. Diagnosing MAFLD, especially with advanced fibrosis, remains challenging due to the limitations of liver biopsy, the current gold standard. Non-invasive tests are crucial for early detection and management. Among these, the fibrosis-4 index (Fib-4) is widely recommended as a first-line test for screening for liver fibrosis. Advanced imaging techniques, including ultrasound-based elastography and magnetic resonance elastography, offer high accuracy but are limited by cost and availability. Combining biomarkers, such as in the enhanced liver fibrosis score and FibroScan-AST score, enhances diagnostic precision and is recommended to further stratify patients who are considered to be intermediate or high risk from the Fib-4 score. We believe that the future lies in the combined use of biomarkers to improve diagnostic accuracy.
Autoimmune liver diseases (AILD) encompass a group of conditions in which the immune system mistakenly attacks the liver tissue. Mucosal-associated invariant T (MAIT) cells are enriched in the liver, where they play crucial roles in antibacterial defense and inflammation regulation. Compared to other autoimmune conditions affecting the synovium of the joints, MAIT cells from AILD exhibited a greater deficiency in ratio, elevated activation markers, increased apoptosis, and higher pro-inflammatory cytokines production. However, the frequency of MAIT cells in AILD was negatively correlated with anti-bacterial indexes, and their impaired responsiveness and weakened anti-bacterial potential were evidenced by reduced expansion ability, lower maximal IFN-γ production, and diminished E. coli-induced cytotoxic mediators release. Similar shifts in MAIT cell ratios and phenotypes were observed in both primary biliary cirrhosis and autoimmune hepatitis, linked to upregulation of bile acid components in the affected tissue. Specifically, ursodeoxycholic acid, a metabolic intermediate and traditional anti-primary biliary cirrhosis drug, inhibited TCR-mediated expansion and downregulated pro-inflammatory cytokines and anti-bacterial-related mediators in MAIT cells. These findings underscore the intricate interplay between hepatic pathology and MAIT cells, and highlight the importance of antibacterial monitoring during ursodeoxycholic acid treatment in AILD.
Perineal trauma is the damage caused by rupture, laceration or episiotomy during birth. Birth-related perineal trauma can lead to many short and long-term physical and psychological morbidities that affect the woman's life. Problems such as pain, bleeding and delay in the attachment of mother and newborn appear in the early postpartum period. In the following period problems such as prolapse, incontinence, sexual dysfunction and anxiety may be experienced.

This randomised controlled study was executed at a research hospital between May 2018 - September 2019. The sample of study is made consisted of three intervention groups and a control group of total 120 pregnant women by randomisation method. Perineal massage, perineal warm compress application, perineal massage and warm compress was done to the intervention groups respectively. Nothing was done to the control group. Perineal massage was given for 10 minutes, warm compress application was done 30 minutes three times when cervical dilatation 3-4 cm, 5-7 cm and 8-10 cm respectively. The data was collected by using Socio-Demographic and Obstetric Data Collection Form, First and Second Stage of Labor Stage Data Collection Form, Childbirth Comfort Scale, Newborn Data Collection Form, Perineal Trauma and Bleeding Monitorisation/ Measurement Form, Visual Analogue Scale, Birth Satisfaction Scale and Perineal Massage and Perineal Warm Compress Application Satisfaction Evaluation Form. When evaluating the data; number, percentage, mean, standard deviation, median, ANOVA Test, Tukey Test, Kruskal Wallis Test, Paired Sample T Test, Friedman Test, Ki-Square Test and Fisher's Exact was used.
PURPOSE:To easily control the sustained release speed of heparin by immobilizing heparin in a photo-crosslinked film of a water-soluble photo-crosslinkable resin. CONSTITUTION:Heparin is mixed with an aqueous solution of a water-soluble photo-crosslinkable resin to be formed into a film which is, in turn, irradiated with ultraviolet rays. As the water-soluble crosslinkable resin, a film forming material such as polyvinyl alcohol or polyethylene glycol having a photosensitive group such as a stilbazolium group or a diazo group as a photocrosslinkable group in its molecule is used and heparin is mixed with an aqueous solution containing about 10-30wt.% of the water-soluble photo-crosslinkable resin in a concn. of about 5-15wt.% and the resulting solution is applied to a substrate such as glass and dried at room temp. for about 1-3hr to be formed into a film. This film is irradiated with ultraviolet rays with a wavelength of 3000-4500Angstrom  for about 1-60 sec to be photo-crosslinked and heparin is immobilized in the film.
The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
Several potential risk factors have been identified in the etiopathogenesis of febrile seizures (FS), including the type and extent of breastfeeding (BF). Given the lack of conclusive data, this study aims to systematically evaluate the evidence on the association between BF and FS. We conducted a systematic review and meta-analysis according to PRISMA guidelines. The search was conducted using descriptors for FS, BF, and formula feeding in MEDLINE, Embase, and Web of Science databases. We included observational studies that compared the incidence of FS between those who had ever breastfed and those who were formula fed. The study protocol was registered on the PROSPERO platform under the number CRD42023474906. A total of 1,893,079 participants from 8 datasets were included. Our main analysis showed no significant association of any type of BF on the incidence of FS compared with formula-fed children (OR: 0.84; CI: 0.67-1.04; I2 = 78%; Cochran's Q = 0.0001), although meta-regression showed that BF was associated with a lower incidence of FS in preterm infants. Our secondary outcome showed a significantly reduced incidence of FS in children who received BF exclusively (OR: 0.80; CI: 0.65-0.99; I2 = 70%; Cochran's Q = 0.02).    Conclusion: There was no significant reduction in the incidence of FS in those who were breastfed compared to formula feeding. However, our meta-regression analysis indicated an association between BF and a lower incidence of FS in preterm infants. Additionally, children who exclusively received BF had a significantly reduced incidence of FS. These findings should be further investigated in prospective cohorts. What is Known: • Breastfeeding can modify risk factors for febrile seizures, such as susceptibility to viral and bacterial infections, micronutrient deficiencies, and low birth weight. • However, studies have shown conflicting results regarding the impact of breastfeeding on febrile seizures. What is New: • When comparing any breastfeeding pattern with no breastfeeding, there is no significant difference in the incidence of febrile seizures. • When comparing exclusive breastfeeding with no breastfeeding, there may be a decrease in the occurrence of febrile seizures.
PURPOSE:To provide a blood substitute having excellent oxygen-supplying performance, and containing an oxygen carrier comprising a compound composed of hemoglobin and polyalkylene glycol bonded with each other by an amide bond. CONSTITUTION:A blood substitute containing a hemoglobin-polyalkylene glycol adduct as an oxygen carrier, wherein said hemoglobin is bonded with said polyalkylene glycol through an amide bond. The polyalkylene glycol is a polymer such as polyethylene glycol, etc. having a molecular weight of about 300-20,000, and the hemoglobin may be modified with pyridoxal-5'-phosphate, etc. The bonding with amide bond is carried out e.g. by adding carboxyl group to polyalkylene glycol, and condensing the carboxyl group with the amino group of hemoglobin.
Titanium implant and G3-coated abutment (control implant, test abutment). Dental sites that potentially qualify for dental implant rehabilitation will be randomly assigned to either the test group (zirconia implants) or the control group (titanium implants). Also, G3-coated and control (non-coated) abutments will be equally distributed on test and control implants, to discriminate between peri-implantitis prevention due to the G3-coating or due to the specific implant characteristics. This is a split-mouth study so that each participant can act as his or her own control and to allow between and within group comparisons.
Dental Implant Screw Hole Closure Plug is a solid plug of dental resin, fabricated by 3D printer machines. The Plugs consist of a Plug (1) ,a Handling Pin (6,7) and a Sinkhole (8). The Plugs close Screw Holes, that are left open after screwing Abutments, Crowns and Sleeves on implants. These Holes have to remain free of obstructions to keep the screw head free. The Holes have to be Closed and Opened on demand in an easy way. The Plugs(1,9,10) are Cylindrical (1), Conical (9) and Double Cylindrical (10) shaped with an extra cylinder on top and have diameters, exactly conform to all open screw holes. They are Straight or Angled leveled at the top heads and adapt to the Sleeves, which Top levels have been shaped on their turn conform Existing Plug Angles. On top of the Plugs is a handling pin (6,7) placed for easy transport and a sinkhole (8) for exact recognition of the center of the screw hole pathways. The Plugs are placed in a One Step Action and cause a friction and a vacuum, that needs no further aids. The handling pin is chipped off after positioning. Plugs are used in the final stages of the dental implant procedures.
A Non-A, Non-B hepatitis (NANBH) viral in vitro cell culture is disclosed. Primary hepatocytes were isolated and cultured from a chimpanzee during the acute phase of an experimental NANBH virus infection. The differentiated hepatocyte cell culture was maintained in a serum-free medium comprising Williams medium E, a hepatocyte proliferogen, transferrin, serum albumin, corticosteroide prolactin, thyrotropin-releasing factor, cholera toxin and ethanolamine. The cultured hepatocytes tested positive for the expression of a NANBH-associated cytoplasmic antigen. The presence of this cytoplasmic marker suggested persistence of the infection in vitro. The production of infectious virus in vitro was confirmed by inoculating a chimpanzee with NANBH virus-infected tissue culture and later documenting the NANBH development in the chimpanzee.
Disclosed are camelid single domain antibody (sdAb) against dendritic cell surface antigens such as Clec9A and CD40. Also disclosed are chimeric adenoviruses which can be used as vaccines against a pathogen or cancer. A chimeric adenovirus targeted to dendritic cells incorporates a sequence encoding an sdAb against a dendritic cell surface antigen. A chimeric adenovirus includes a phage T4 fibritin trimerization foldon to replace the Ad5 fiber knob. Furthermore, the E1A/B genetic region of a chimeric adenovirus can be replaced with a heterologous sequence such as a structural gene from a heterologous virus or a sequence encoding a tumor antigen. Examples of heterologous viruses include flaviviruses such as Zika, Chikungunya, Dengue, yellow fever, and West Nile virus. Exemplary Zika sequences introduced into a chimeric adenovirus include full length prM, and the E ectodomain.
If randomized to Buzzy®, the nurse will demonstrate the cold pack and the device just prior to the IV cannulation procedure. The device will be applied with a Velcro strap 5 centimeters proximal to the site of IV cannulation; it will remain in place until the IV cannula is inserted and secured. All nurses that work during the study hours will be trained on the device prior to beginning the study. Training includes direct one-one training with the device including return demonstration.