anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obesity is recognized as a major risk factor for the development of endometrial cancer. Notably, several retrospective studies have shown that obesity reduces complete remission and pregnancy rates and increases recurrence rates in patients with endometrial cancer and atypical hyperplasia who undergo fertility-sparing treatment. Guidelines or consensus statements for fertility-sparing treatment in endometrial cancer recommend weight management. However, prospective intervention studies on the effectiveness of systematic weight management models in patients receiving reproductive function-preserving treatment for endometrial cancer and atypical hyperplasia are lacking. This study therefore aimed to investigate the impact of the weight management on body morphology and composition, glycolipid metabolism, and tumor outcomes in overweight and obese patients with endometrial cancer and atypical hyperplasia who underwent reproductive function-preserving treatments.In this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups. The test group was given weight management, while the control group was given routine care. Relevant information such as body morphology and composition, glycolipid metabolism, molecular typing and tumor outcomes of the subjects were collected. By evaluating the tumor outcome and changes in glycolipid metabolism indicators, to confirm the effectiveness and safety of weight management for overweight and obese patients with endometrial cancer and treatd with fertility preservation.
A prospective opened, placebo uncontrolled, pilot interventional study is performed at the Morbid Obesity Unit of the Vall Hebron University Hospital, including patients that have previously undergone RYGB at our site and were diagnosed with PHH. The control group comprises of healthy normoweight persons matched by age, most of them family members of patients included in the study. The OGTT is performed as follows: a solution of 100g glucose was administered at 8am after 10 hours of fasting. Plasma glucose and serum insulin are measured at minute -5, +30, +60, +120, +180 after the ingestion of the glucose solution. A first OGTT is performed in basal conditions. The control group only will perform the basal OGTT. A value of plasma glucose below 50mg/dl at 60-180 minutes after the administration of the glucose solution is considered positive for PHH. The patients that additionally present a value of plasma glucose\>200mg/dl during the OGTT will be selected for continuing in the study and will be prescribed canagliflozin 300mg orally daily, during 2 weeks. After 2 weeks of canagliflozin treatment, a new OGTT will be performed and, in the patients that sign the additional inform consent, the pancreatic catheterism will be realized.
Mechanical ventilation has been linked to diaphragm injury and dysfunction. During mechanical ventilation, the amount of breathing work done by the diaphragm is unpredictable: the diaphragm could be completely rested, or it could be overworked. Either of these possibilities may cause injury to the diaphragm. Patients with an injured and dysfunctional diaphragm have greater difficulty weaning from mechanical ventilation - they become too weak to breathe. However, little is known about the relationship between changes in the diaphragm and the histological (structure of cells and tissue) basis of these changes. The investigators have developed a new technique employing beside ultrasound to measure diaphragm thickness. This allows them to observe changes in diaphragm muscle structure and function.

The goal of the study is to determine whether different forms of respiratory support (mechanical ventilation vs extracorporeal life support) lead to different degrees of diaphragm injury and to compare changes in the diaphragm seen on ultrasound to changes in the diaphragm tissues under a microscope. This will help the investigators to confirm the best way to avoid diaphragm injury and to understanding the meaning of diaphragm ultrasound images.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic composition containing an extract from a plant belonging to the genus Cucurbitaceae Melothria, effective for preventing/treating freckles, etc., having excellent skin-whitening effect and stability and safety to the skin. SOLUTION: This safe and highly effective cosmetic composition contains, as active ingredient, 0.1-10wt.% of an extract obtained from a plant (esp. its tuberose roots) belonging to the genus Cucurbitaceae Melothria such as Melothria indica, Melothria heterophylla or Melothria japonica using a hydrophillic solvent (e.g. water-ethanol). The composition can be prepared into medicinal cosmetics as quasi drugs such as lotion, milky lotion, cream, pack and soap, or preparations for external use for skin as medicines such as lotion, milky lotion, cream and ointment. The extract highly suppresses melanogenesis and is extremely weak in cytotoxicity.
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric illness that frequently begins in childhood. It is characterized by obsessions and/or compulsions that are distressing, time consuming and significantly impairing. OCD is distinct in the extent to which it disrupts family functioning, in that there is intense parental pressure to become involved in rituals and to change home environments and schedules to avoid triggers, thus accommodating the OCD. It is also well known that OCD severity tends to worsen in the context of stressful environments and situations. While effective treatment approaches for pediatric OCD have been identified, partial response and treatment refusal are all too common, leading to chronicity of both the illness itself and of its deleterious familial effects.

The investigators plan to study a novel approach to help manage the stress of parenting a child with OCD, thus facilitating more effective resistance to OCD family accommodation and supporting the child in fighting this difficult illness. The investigators will explore the role of group-based mindfulness-based skills training (P-MBST) in supporting parents of OCD-affected youth, in particular investigating the possibility that increased distress tolerance as a result of mindfulness practice may help parents reduce OCD accommodation.
PROBLEM TO BE SOLVED: To obtain the subject enzymatically stable complex glycopeptide that can be expected to improve the stability and pharmaceutical action in situ and is useful for medicines by preparing a complex glycopeptide that is stable to an enzyme peptide: N-glycanase. SOLUTION: The objective compound is obtained by preparing a complex glycopeptide derivative that is stable to an enzyme peptide: N-glycanase (EC. 3. 5. 1. 52) preferably bearing a saccharide chain linking to the residual group of L-glutamine(Gln) in the peptide via the N-glycoside bond. The saccharide chain is introduced by using 9-fluorenylmethyloxycarbonyl-glutaminyl-N- acetylglucosaminide prepared by linking N-acetyl-D-glucosamine (GlcNAc) to Gin as a synthetic unit, to synthesize the glycopeptide to which GlcNAc is linked at the Gln residue through the solid phase method and by transfer-adding a saccharide chain to the resultant glycopeptide by using an enzyme: endo-β-N- acetylglucosaminidase.
Subjects with recurrent symptomatic nasal obstruction will be treated by Airiver Nasal Drug Coated Balloon (DCB) Catheter at the index procedure. The balloon is coated with a paclitaxel drug (3.5ug/mm2).
Topical ketorolac tromethamine 0.5% is a nonsteroidal anti-inflammatory drug. It is FDA-approved for the treatment of inflammation following cataract surgery and relief of ocular itching due to seasonal allergic conjunctivitis.
Youth with IBD experience abdominal pain, diarrhea, weight loss, and psychological suffering related to their disease process. While many biologic and non-biologic therapies are available to target the inflammatory component of IBD, youth with IBD could benefit from a more holistic therapy that addresses psychological wellness, which has been shown, in turn, to reduce disease burden. It is known that stress (multiple varieties) leads to IBD flares. It is also known that mind-body intervention reduces stress. The mind-gut connection is widely discussed in medical circles, however, current therapies have not capitalized on it. The investigators would like to know if an easily accessible mind-body intervention (yoga) can improve wellness, lower stress levels, and reduce intestinal inflammation in youth with IBD.

The study will be an 8-week feasibility pilot. Participants will be asked to participate in online yoga videos and in-studio yoga sessions. Participants will be asked to complete multiple surveys throughout the intervention and continue receiving standard care from their primary gastroenterology team.
The use of helmet therapy to correct abnormal head shape due to either positional plagiocephaly secondary to pressure on the posterior skull with infant position and furniture use or after minimally invasive surgery for craniosynostosis is currently the treatment of choice at Cincinnati Children's Hospital (CCHMC). Helmet treatment in children with positional plagiocephaly is initiated for infants between 4 and 9 months of age (at CCHMC). Helmet treatment for children undergoing surgery for craniosynostosis is initiated following endoscopic cranial vault and stip craniectomy surgery after swelling from the surgery has subsided (generally within two weeks of surgery). Treatment with helmet therapy has been shown to improve head shape in both patient diagnoses. There are two types of helmets available to the investigators' patients (Hanger Helmet and P Pod Helmet) and to date, no research has evaluated whether one helmet type is more efficient in reshaping the skull than the other type. The current study seeks to fill this gap in the literature by comparing the outcomes for infants treated with a Hanger Helmet to the outcomes for infants treated with a P Pod Helmet. The investigators will measure skull symmetry with a 3dMD camera and take routine cross lateral measurements with a caliper designed for this use. Infants participating in the study will be randomized using a computerized program, Minim.
Participants randomly assigned to the event-driven TDF/FTC arm will be instructed to take a loading dose of two single tablets containing coformulated TDF/FTC (300/200mg) 2 to 24 hours before sexual intercourse, followed by a third pill 24 hours after the first drug intake and a fourth pill 24 hours later. In case of daily sexual intercourses, they will be instructed to take one pill per day until the last sexual intercourse, then to take the two post-exposure pills.
Will include 10 seconds of ramp in to 1 minute of 10 Hz tACS with a ramp out of 10 seconds for a total of 80 seconds of stimulation. Uses tACS (alpha) device.
To investigate the efficacy of Ursolic acid in alleviating neuropathic pain in rats with spinal nerve ligation (SNL), the SNL rat model was surgically induced. Different concentrations of Ursolic acid and manipulated target mitogen-activated protein kinase 1 (MAPK1) were administered to the SNL rats. Fecal samples were collected from each group of rats for 16S rDNA analysis to examine the impact of gut microbiota. Molecular docking experiments were conducted to assess the binding energy between Ursolic acid and MAPK1. In vivo studies were carried out to evaluate the expression of inflammatory factors and signaling pathways in spinal cord and colon tissues. Ursolic acid was found to have a beneficial effect on pain reduction in rats by increasing plantar withdrawal latency (PWL) and paw withdrawal threshold (PWT). Comparing the Ursolic acid group with the control group revealed notable differences in the distribution of Staphylococcus, Allobaculum, Clostridium, Blautia, Bifidobacterium, and Prevotella species. Network pharmacology analysis identified MAPK1 and intercellular adhesion molecule-1 (ICAM1) as common targets for Ursolic acid, SNL, and neuropathic pain. Binding sites between Ursolic acid and these targets were identified. Additionally, immunofluorescent staining showed a decrease in GFAP and IBA1 intensity in the spinal cord along with an increase in NeuN following Ursolic acid treatment. Overexpression of MAPK1 in SNL rats led to an increase in inflammatory factors and a decrease in PWL and PWT. Furthermore, MAPK1 counteracted the pain-relieving effects of Ursolic acid in SNL rats. Ursolic acid was found to alleviate neuropathic pain in SNL rats by targeting MAPK1 and influencing gut microbiota homeostasis.
For both types of treatment, 0.25x30mm stainless steel needles were used (Dux, Brazil).The protocols were differentiated by needle size, in which the placebo needle is not inserted into the patient's skin and has an identical appearance to the active needle.The needle measuring 0.25x30mm was used as an active needle. The needles were inserted partially into an opaque guide tube filled with condensation silicone. This process was used to simulate the needle insertion for the patient and the acupuncturist and for the needle support. The active needle as well as the placebo needle were attached to the skin with an adhesive pedestal to hold the needle in place, even without inserting it into the skin.
In patients with malaria, quinidine acts primarily as an intra-erythrocytic schizonticide, with little effect upon sporozites or upon pre-erythrocytic parasites. Quinidine is gametocidal to Plasmodium vivax and P. malariae, but not to P. falciparum.

In cardiac muscle and in Purkinje fibers, quinidine depresses the rapid inward depolarizing sodium current, thereby slowing phase-0 depolarization and reducing the amplitude of the action potential without affecting the resting potential. In normal Purkinje fibers, it reduces the slope of phase-4 depolarization, shifting the threshold voltage upward toward zero. The result is slowed conduction and reduced automaticity in all parts of the heart, with increase of the effective refractory period relative to the duration of the action potential in the atria, ventricles, and Purkinje tissues. Quinidine also raises the fibrillation thresholds of the atria and ventricles, and it raises the ventricular defibrillation threshold as well. Quinidine's actions fall into Class Ia in the Vaughn-Williams classification.

By slowing conduction and prolonging the effective refractory period, quinidine can interrupt or prevent reentrant arrhythmias and arrhythmias due to increased automaticity, including atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia.

In patients with sick sinus syndrome, quinidine can cause marked sinus node depression and bradycardia. In most patients, however, use of quinidine is associated with an increase in the sinus rate.

Like other antiarrhythmic drugs with Class Ia activity, quinidine prolongs the QT interval in a dose-related fashion. This may lead to increased ventricular automaticity and polymorphic ventricular tachycardias, including torsades de pointes (see WARNINGS).

In addition, quinidine has anticholinergic activity, it has negative inotropic activity, and it acts peripherally as an α-adrenergic antagonist (that is, as a vasodilator).
PURPOSE:To provide the titled preparation composed of a formed solid material of expanded ethylcellulose and a drug contained in the shell and/or core of the formed material, floating and remaining in stomach over a long period and capable of continuously releasing the drug to prolong the drug action. CONSTITUTION:A drug (exhibiting the activity in stomach and desired to have prolonged drug action; e.g. an antipyretic, analgesic and anti-inflammatory agent such as mefenamic acid, an anti-arrhythmic agent such as acebutolol hydrochloride, a hypotensor such as clonidine hydrochloride, etc.) is used as a component of the shell and/or core of a formed solid material of expanded ethylcellulose (preferably formed in the form of pill or pellet) to obtain the objective drug preparation having prolonged activity. The expanded ethylcellulose can be produced by heating an ethoxy derivative of cellulose having an ethoxy-content of 44.0-52.0%, pressurizing with an inert gas and rapidly releasing the pressure to effect the expansion of the cellulose. It is used in the form of powder, granule, tablet, etc.
Volunteer athletes who agreed to participate in the thesis were initially administered tests measuring balance, posture, motor control and swimming speed. After the tests, in addition to their own training, 3 sham pectoralis minor stretching exercises with a total duration of 15 minutes, were applied for 8 weeks, at least 2 times a week.
The Coronavirus Disease 2019 (COVID-19) pandemic has killed \>129,000 Americans as of June 30, 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2). ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase ACE2 expression. Theoretically, if ACEI/ARB use increases ACE2 expression in the lungs, ACEI/ARBs could promote SARS-CoV-2 entry into type II pneumocytes and worsen COVID-19 infection. In contrast, other evidence suggests that ACEI/ARBs may mitigate virus-induced inflammatory responses in the lungs by upregulating ACE2-mediated generation of the vasodilator and anti-inflammatory protein angiotensin-(1-7), thereby preventing tissue damage. Few data exist on the direction or magnitude of the association between ACEI/ARB use and COVID-19 severity, and whether these associations differ between ACEIs and ARBs. Because ACEI/ARBs are among the most commonly used prescription medications, it is critical to determine if ACEI/ARB users have a differential risk of more severe COVID-19 infection compared to non-users. The objective of this study is to reduce morbidity and mortality of the COVID-19 pandemic by generating timely evidence on the direction and magnitude of the association between ACEI/ARB use and COVID-19 severity and mortality.
PURPOSE: To provide a method for determining the degree of deterioration of glycerol-contg. gelatin capsule film by nuclear magnetic resonance spectrum. CONSTITUTION: The solid nuclear magnetic resonance spectrum for glycerol- contg. gelatin capsule is determined. And at least one peak among two peaks corresponding to the 73.0-74.0ppm and 63.0-66.0ppm inherent in the glycerol, the peak inherent in the carbon atom on γ-site of hydroxyproline appearing on the higher magnetic field side of the above former peak, the peak inherent in the carbon atom on α-site of proline appearing on the higher magnetic field side of the above latter peak, the peak inherent in the α-site of the hydroxyproline, and the peak inherent in the carbon atom on the α-site of the hydroxyproline, is compared with at least one peak among those mentioned above for the glycerol-contg.  capsule as the standard item, and the degree of deterioration of the gelatin capsule is determined based on, an indicator, peak waveform's fission, broadening and/or attenuation.
Hyperpigmentation is a common skin disorder with serious psychosocial consequences. Decapeptide-12 is a newly synthesized peptide that has been found to be safer than hydroquinone in reducing melanin content, with efficacy of up to 50% or more after 16 weeks of twice daily treatment. However, the peptide has limited transdermal penetration due to its hydrophilicity and large molecular weight. Thus, decapeptide-12 was modified by the addition of palmitate chains in an attempt to overcome this limitation. We also tested the effect of chemical permeation enhancers and microneedles on the delivery of both peptides through the skin. Enhanced human skin penetration was found using an in vitro skin penetration model. Furthermore, we examined peptide retention for the different formulations. Our data shows that the palmatine in microneedle patches is most effective.
Patients undergo collection of tissue and blood samples (and optional stool samples from patients experiencing colitis) at the time of registration (within 72 hours of confirmation of one or more severe irAEs) and at 1 month after registration. Patients' medical records are also reviewed for up to 1 year.
The invention provides a kusnezoff monkshood root fever reducing and diuresis causing electuary and a production method. Kusnezoff monkshood roots, caulis aristolochiae manshuriensis, juncaceae, fresh bamboo leaves, Japanese climbing fern spore, caulis clematidis armandii, jujube, fructus kochiae, lotus seeds, Chinese waxgourd peel and polygonum aviculare serve as main raw materials. The production method includes the main process flow of material selecting, drying, smashing, pelletizing, packaging and finished product obtaining. The kusnezoff monkshood root fever reducing and diuresis causing electuary has the advantages that health care, diuresis and blood sugar reduction are achieved, and the kusnezoff monkshood root fever reducing and diuresis causing electuary is quick in effect, pure natural, free of toxin and side effects, and the like. The kusnezoff monkshood root fever reducing and diuresis causing electuary has a good auxiliary treatment effect on difficult urination and other diseases. The kusnezoff monkshood root fever reducing and diuresis causing electuary and the production method are suitable for home eating.
PURPOSE:To obtain a new compound useful as a nerve growth factor-production inducer or antifungal agent. CONSTITUTION:A cyathan derivative of the formula. This compound can be obtained by the following process: mycelia of Hydnum erinaceum, a kind of mushroom belonging to Hydnaceae, is cultured, and the cultured mycelia is divided into supernatant and precipitate by centrifugation, and the precipitate is put to extraction with water and an organic solvent, and the extract is fractionated by e.g. a chromatography. The physicochemical properties of the compound of the formula are as follows: molecular formula, C25H36O6; solubility, soluble to chloroform, acetone, ethyl acetate, methanol, partially soluble in ethanol, insoluble in water; appearance, colorless and neutral oily substance. This compound which has nerve growth factor production-inducing activity can be used as a medicine for geriatric dementia, or used as a natural antifungal agent for foods.
PURPOSE:To reduce the damage of blood corpuscles and to make a leucocyte removing rate and an erythrocyte recovery rate excellent, by constituting a filter of nonwoven fabric using a synthetic fiber having predetermined monofilament fineness and a profile cross-section whose surface area increase rate is a specific value or more. CONSTITUTION:The fineness of the monofilament of a synthetic fiber constituting a blood filter is set to 0.25 denier or less, pref., to 0.1 denier or less and the cross-section of the monofilament has an odd-shape and the surface area increase ratio F=l/(4pis)1/2(wherein l is the average outer peripheral length of the monofilament cross-section and s is the average cross-section of the monofilament cross-section) is 1.15 or more. This synthetic fiber is in an opened state. Since the synthetic fiber constituting the blood filter has the profile cross-section, an increasing surface area increase ratio is 1.15 or more, pref., 1.30 or more as compared with a round cross-sectional fiber and the surface area increase ratio of 1.15 or less is not pref. because the enhancement of the removal rate of a leucocyte is less as compared with the round cross-sectional fiber. By this method, even when the diameter of a fiber is not made too small and a filling rate is not enhanced, the contact surface area of the fiber with a leucocyte is increased, and a leucocyte removing rate and an erythrocyte recovery rate are made excellent.
Group of Tai Chi intervention include 18 patients with AS. Tai Chi exercise method, which is composed of combination of physical exercise and relaxation techniques, will be applied by an experienced physiotherapist who is trained with Tai Chi. The training will take 60 minutes, 2 days a week and 10 weeks in total.