anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a 3-nitrogen mustard-2-sulfonyl acrylonitrile derivative with anti-tumor activity, and a preparation method and application thereof, belonging to the technical field of biological medicine. The structural formula is shown as formula I:  Wherein R is selected from hydrocarbyl, aryl or pyridyl. The invention takes 4- [ bis (beta-chloroethyl) amino ] benzaldehyde and sulfonyl acrylonitrile compounds as raw materials, and synthesizes a series of novel 3-nitrogen mustard-2-sulfonyl acrylonitrile through one-step reaction. The method is simple, the separation and purification are simple and convenient, and the yield is high. Meanwhile, cytotoxicity experiments prove that the compounds have anti-tumor activity and better inhibition capability on the growth of lung cancer cells. The present invention provides a novel, predominantly pharmaceutically acceptable compound; the preparation method of the novel compound has the advantages of few operation steps, few side reactions, readily available raw materials, environment-friendly solvent and easy separation and purification of products. The medicine has good anti-tumor activity.
Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop radiographic knee osteoarthritis (OA) within 15 years. The resulting pain, reduced quality-of-life, and increased risk for co-morbidity lead to substantial healthcare costs, inability to fulfill work and personal responsibilities, and reduced long-term health. Articular cartilage degeneration is the hallmark sign of early OA development after knee injury. This deterioration can be measured by increased T2 and T1rho relaxation time on quantitative magnetic resonance imaging (MRI), an imaging biomarker for OA development. Harmful increases in MRI markers of the knee's articular cartilage occur within months of ACL injury and indicate preventative interventions should begin soon after injury. However, evidence-based interventions to prevent OA do not exist. The investigators have shown that after ACL reconstruction (ACLR), patients exhibit asymmetric movement patterns characterized by up to 62% lower knee joint loading during walking and squatting in the injured limb at two months after ACLR. These knee joint loading patterns remain 40% lower at six months. Emerging evidence suggests knee joint unloading patterns after ACL injury may increase the risk for OA development. Currently, no studies have examined the efficacy of movement-focused interventions during the first months after ACLR, which explains the lack of evidence-based interventions that successfully increase knee loading early after ACLR. This gap presents a barrier to the research team's long-term goal of preventing OA in young, active individuals before irreversible knee degeneration occurs. This project will challenge the traditional OA paradigm that too much joint loading (e.g. "wear and tear") causes cartilage breakdown. The multi-disciplinary team spanning rehabilitation, orthopaedics, radiology and biomechanics has developed a novel visual biofeedback paradigm using portable force plates that can increase knee loading during squats within a single session after ACLR. This data suggest movement is modifiable using visual feedback, but its efficacy beyond a single training session is unknown. This study will determine the efficacy of the visual biofeedback program initiated two weeks after ACLR by assessing movement biomechanics and MRI changes in cartilage microstructure six months later. Successful completion of this project will establish the first rehabilitation intervention to effectively and optimally load the knee joint early after ACLR, providing the initial steps in the team's work to prevent OA after ACL injury.
This study is a retrospective natural history study of MLIV. It involves the collection of all participants medical records prior to the date of consent.

First, the study will provide an approximate description of the international MLIV population, which could inform the feasibility and design of interventional trials. Second, the results will be used to create an MLIV specific developmental timeline (akin to the Denver Developmental Screen (Frankenburg and Dodds, 1967)) against which a patient's developmental trajectory pre- and post-treatment can be compared. Third, the study will assess the reliability and validity of the GMFCS and our MLIV specific scales when applied retrospectively. These scales could provide longitudinal, quantitative historical data on the level of function and disability in MLIV patients. The scales could be used as endpoints in future trials or provide historical context for interpretation of treatment effects. Fourth, the study will define the rate of visual decline in patients, which could be halted by gene therapy targeted to the retina. Fifth, the study will analyze the natural history of MLIV associated EEG and brain MRI abnormalities, aiming to establish biomarkers of disease progression. And finally, the study will provide baseline data on clinical measures used to monitor for gene therapy treatment side effects (inflammatory markers, liver enzyme levels, etc.) across the life span of patient with MLIV.
Damage to biological membranes is prevented or repaired by treating the membranes with small amounts of natural or artificial lipid mixtures contg. phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine and unsaturated fatty acids. Protection of biological membranes of plants and animals against damage by chemical agents (e.g. water miscible alcohols, cardioactive steroids etc), surface active against, UV-irradiation, and disturbances of biological transport. The method is of particular significance for protecting the human skin against damage by detergents and UV-irradiation, and for repairing damage caused by these agents. Lipid mixtures can also be used to restore photosynthetic activity in aged plants.
Dry eye disease (DED) is a common but often inadequately treated disease of the tears and surface of the eye. It can cause poor vision and chronic pain and is more frequent with increasing age. Inflammation may be an important component of this disease. This is supported by the observation that cyclosporine, a drug that targets the immune system, is approved for and effectively treats DED. Inflammatory processes likely produce ocular surface damage and contribute to chronic DED. Because not all people with DED respond to current anti-inflammatory treatments, other immune-modulating treatments would be of value. Furthermore, despite a great deal of evidence supporting DED as an inflammatory disease, not all researchers currently agree with this classification. More data that specifically measures inflammatory responses in DED needs to be collected in a well-characterized patient population and correlated with signs and symptoms of DED in order to improve our understanding and classification of the disease.

Essential Fatty Acids (EFA) have been shown to diminish inflammatory responses in many human inflammatory diseases, and interest in the use of omega-3 and omega-6 fatty acids for disease treatment has resulted in several small studies as well as the use (and over-the-counter availability) of EFA-containing nutritional supplements, including several specifically for the treatment of DED. Despite this interest in EFA for DED, there are no strong empirical data from a well-controlled randomized controlled trial RCT supporting the use of EFA for DED. We postulate that DED is an inflammatory disease and hypothesize that EFA can mediate immune responses, thus improving DED signs, symptoms and associated measures of inflammation. The proposed three month feasibility study allows us the chance to demonstrate our ability to successfully execute our own protocol with compliance from the study patients before we begin the process of initiating a full-scale multi-center trial.
The present invention provides an inhalation-type pharmaceutical composition for kidney disease comprising a first gas and a vaporized pharmaceutical liquid. The first gas comprises hydrogen. The hydrogen has a gas volume concentration between 2% and 96% in the inhalation-type pharmaceutical composition. The vaporized pharmaceutical liquid comprises at least one selected from the group consisting of corticosteroid, angiotensin converting enzyme inhibitor, angiotensin II receptor blocker, diuretics, erythropoietin, and phosphate binding agent. The inhalation-type pharmaceutical composition of the present invention can remove reactive oxygen, and the vaporized pharmaceutical liquid can improve absorbability in the present invention. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid indirectly reduce the side effects of human.
BACKGROUND: Malaria affects the intravascular environment, leading to abnormal coagulation activation, prolonged prothrombin time, and activated partial thromboplastin time. Despite the high prevalence of malaria in the study area, there has been little published research on the effects of Plasmodium infection on coagulation parameters.
OBJECTIVE: The aim was to assess the effect of malaria on basic coagulation parameters among patients attending Dembia Primary Hospital and Makisegnit Health Center.
METHODS: A cross-sectional study was carried out from January to March 2020. The study involved 120 participants. Blood specimens were collected, which were analyzed using a Huma Clot Due Plus analyzer. The collected data were entered into EpiData and exported to SPSS version 21 for analysis. Non-parametric statistical methods were employed to analyze the data. The results were considered statistically significant if the p-value was less than 0.05.
RESULTS: Individuals infected with Plasmodium exhibit coagulation disorders with elevated levels of PT (Prothrombin Time), APTT (Activated Partial Thromboplastin Time), and INR (International Normalization Ratio) in comparison to healthy controls. The median PT, APTT, and INR values for infected cases were measured at 20.5 [8.6], 39.5 [17.9], and 1.8 [0.9], respectively, while healthy controls had measurements of 15.1 [2.5], 28.8 [8.3], and 1.3 [0.2] (p ≤ 0.001). The severity of coagulation disorders increased with an increase in parasitemia levels. The type of Plasmodium species present had a significant impact on PT and INR values (p ≤ 0.001), whereas APTT did not show any significant impact across the Plasmodium species (p > 0.05).
CONCLUSION: The results of this study found that malaria has a substantial impact on various blood clotting parameters, including PT, APTT, and INR. Parasitemia severity is significantly associated with extended PT and INR, implying that the higher the parasitemia, the longer it takes for blood to clot. Furthermore, the study discovered that the PT and INR levels differed based on the type of Plasmodium species responsible for the infection.
Micro-enema compositions consist of an aqueous solution comprising a salt (e.g. alkali metal, ammonium or organic base) of an aliphatic polybasic hydroxy acid e.g. citric, tartaric, malic or ascorbic acid and a polyhydroxy alcohol having at least five hydroxyl groups e.g. mannitol, sorbitol and dulcitol (all preferred), arabitol, xylitol and adonitol. Optional additional ingredients are glycerol, local anaesthetics e.g. butethamine formate, nupercaine hydrochloride and amylsine hydrochloride, anionic, cationic and non-ionic wetting agents, pH-stabilizers and viscosity increasing agents all of which are exemplified.
A long-term non-randomized, non-placebo controlled clinical trial with eighteen adult patients with uric acid lithiasis participated in the study. Six patients formed only uric acid stones, and the remaining 12 patients formed mixed stones containing both uric acid and calcium salts or formed both uric acid stones (without calcium salts) and calcium stones (without uric acid) on separate occasions.  
  
Eleven of the 18 patients received potassium citrate alone. Six of the 7 other patients also received allopurinol for hyperuricemia with gouty arthritis, symptomatic hyperuricemia, or hyperuricosuria. One patient also received hydrochlorothiazide because of unclassified hypercalciuria. The main inclusion criterion was a history of stone passage or surgical removal of stones during the 3 years prior to initiation of potassium citrate therapy. All patients received potassium citrate at a dosage of 30-80 mEq/day in three-to-four divided doses and were followed every four months for up to 5 years.  
  
While on potassium citrate treatment, urinary pH rose significantly from a low value of 5.3 ± 0.3 to within normal limits (6.2 to 6.5). Urinary citrate which was low before treatment rose to the high normal range and only one stone was formed in the entire group of 18 patients.
<P>PROBLEM TO BE SOLVED: To provide an easily-drinkable health tea because a conventional decocted liquid of Coriolus versicolor has faults of easily rotting to require the daily decoction, and to make the long-term drinking difficult because of the extreme time and effort.  <P>SOLUTION: The 5-time concentrated juice of the Coriolus versicolor is made by decocting the Coriolus versicolor for about 2 hr and 30 min. The resultant liquid can prevent the rotting for about 20 days without change when preserved in a refrigerator by being filled in a PET bottle. The liquid can easily be drunk without time and effort when being drunk. Lemon juice, honey or the like can be easily mixed therewith to remove the smell peculiar to the Coriolus versicolor and to enable the concentrated juice to be drunk with pleasure by a small amount to achieve large efficacy.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The invention discloses a traditional Chinese medicine for treating anemia, which comprises the following raw materials in part by weight: 5 to 15 parts of Chinese angelica, 8 to 15 parts of dried orange peel, 3 to 10 parts of immature bitter orange, 5 to 10 parts of hawthorn fruit, 10 to 15 parts of chicken's gizzardskin, 5 to 10 parts of malt, 5 to 1t parts of astragalus, 5 to 15 parts of Codonopsis pilosula, 8 to 15 parts of white paeony root, 10 to 15 parts of rehmanniae vaporata, 5 to 10 parts of longan, 10 to 20 parts of suberect spatholobus sem, 3 to 10 parts of liquoric root, 5 to 15 parts of large head atractylodes rhizome, 10 to 30 parts of fructus ligustri lucidi and 10 to 15 parts of donkey-hide gelatin. The raw material components of the formula are mixed and decocted for three times and decocted for 30 to 50 minutes each time. The decoction is taken by three times, namely one time in the morning, one time at night, and one time in the morning of next day. 10 medicines form a treatment period. And cold and spicy foods are prohibited when the medicine is taken. The medicine is pure traditional Chinese decoction and has the effects of tonifying qi of middle-jiao energy, tonifying spleen, soothing liver, regulating qi, promoting digestion, appetizing, cooling blood, stop bleeding, clearing liver, clearing away heat, regulating kidney, promoting generation of body fluid, tonifying Qi and promoting blood generation. The medicine is a pure traditional Chinese medicine, prevents side effect after being taken and is good in treatment effect and quick in effectiveness.
PURPOSE: To compare the safety and effectiveness of n-butyl cyanoacrylate (nBCA)-ethiodized oil (NE) mixture and nBCA-ethiodized oil-ethanol (NEE) mixture embolization for Type II endoleak (T2EL) after endovascular aortic repair.
MATERIALS AND METHODS: This study included 32 patients with 49 procedures who underwent T2EL embolization between January 2008 and June 2022. Cases with no follow-up after embolization, technical failure, treatment with coil only, Type I endoleak at the embolization, and re-embolization were excluded. The resultant final cohort included 24 patients (14 men and 10 women; mean age, 83.3 years [interquartile range, 77-89 years]) who underwent initial T2EL embolization, with 15 patients in the NE group and 9 patients in the NEE group. The 2 groups were compared in terms of adverse events (AEs), freedom from sac enlargement, and freedom from reintervention.
RESULTS: The follow-up period after embolization for T2EL was 960 days (SD ± 1,007) in the NE group and 484 days (SD ± 192) in the NEE group, without significant differences. No AEs above moderate were observed in either group. The rate of freedom from sac enlargement at 1 year was 65.0% in the NE group and 87.5% in the NEE group (P = .03). The rate of freedom from reintervention at 1 year was 69.2% in the NE group and 100.0% in the NEE group (P = .02).
CONCLUSIONS: The NEE group had significantly higher rates of freedom from sac enlargement and reintervention at 1 year compared with the NE group. These results suggest that T2EL embolization with NEE may be more effective than that with NE.
Penicillin allergy is the most common of self-reported drug allergies and un-verified penicillin allergy is a significant and growing public health problem. 10% of all patients report penicillin allergy. However, there is large discrepancy between reported penicillin allergy and true allergy. Despite its high prevalence, greater than 90% of such patients are in fact able to tolerate the medication without allergic reactions.

In this study patients having a penicillin allergy label will be investigated to confirm or to exclude the allergy diagnosis. The diagnostic value of the allergen test panel and the allergologic work-up will be evaluated. Clinical parameters as well as immunological will be assessed.
The present study examined whether literacy difficulties in both grades 2 and 3 are associated with social and generalized anxiety within the school environment in grade 5 and if children with different literacy difficulties differ in anxiety levels compared to typically developing children in grade 5 after controlling for inattention. Sixty-nine Greek children with literacy difficulties and fifty-two children with typical literacy development were assessed at the beginning of grade 2 and at the end of grade 3 on standardized literacy measures (reading accuracy, text-reading fluency, reading comprehension, and spelling). In grade 5, teachers were asked to rate their children's social and generalized anxiety levels and inattentive behavior in the school context. Results of one-way ANCOVAs showed that children with literacy difficulties were experiencing more social anxiety than typically developing children. Furthermore, children with both reading and spelling difficulties, but not those with single reading or spelling difficulties, had more social anxiety. These findings suggest that there is a close connection between early literacy difficulties and social anxiety in upper elementary grades and particularly among children with both reading and spelling difficulties. Implications for both teachers and other professionals who support children's socioemotional development will be discussed.
BACKGROUND: Recent studies have reported an association between sarcopenia and depression symptoms. To date, no reports have investigated the association between sarcopenia and depression symptoms evaluated using the Geriatric Depression Screening Scale (GDS)-15 in patients with stroke. Therefore, this study aimed to investigate the association between sarcopenia and its components and the improvement of depression symptoms in patients with stroke admitted to a convalescent rehabilitation ward.
METHODS: Patients with stroke aged ≥65 years admitted to a convalescent rehabilitation ward were included in the study. Participants were categorized into sarcopenia and non-sarcopenia groups based on the 2019 Asian Working Group for Sarcopenia. Here, depression symptoms were evaluated using the GDS-15, in addition to demographic characteristics. This study's primary outcome was the GDS change from admission to discharge. Multiple regression analysis was performed to investigate the association between GDS change and sarcopenia and its components.
RESULTS: Overall, 118 participants were included, with the mean age of 78.7±8.1 years, and 58 (49%) were classified in the sarcopenia group. Multiple regression analysis showed that sarcopenia (β=-0.283, 95% confidence interval [CI] -1.140 to -0.283, p<0.001) and handgrip strength (β=-0.317, 95% CI -0.162 to -0.014, p=0.021) were independently associated with GDS change.
CONCLUSION: Sarcopenia and handgrip strength were significantly associated with improved depression symptoms in patients with stroke admitted to a convalescent rehabilitation ward. However, further prospective studies should investigate the association between sarcopenia and depression symptoms in patients with stroke.
PROBLEM TO BE SOLVED: To provide a ceramide production promoter, a humectant and a skin care preparation for external use that each exhibit an excellent action for promoting production of ceramide that plays an important role in a moisturizing mechanism and a barrier mechanism of the skin.SOLUTION: The ceramide production promoter, the humectant and the skin care preparation for external use contain as an effective ingredient a compound represented by general formula (1). In the formula, R-Rare each independently a hydrogen atom or a 1-12C acyl group. The compound represented by general formula (1) can be isolated, for example, from a plant such as Melia toosendan Sieb. et Zucc. or the like. A fruit or bark is preferably employed in the case of isolation from Melia toosendan Sieb. et Zucc. Melia toosendan, a galenical obtained from a fruit of Melia toosendan Sieb. et Zucc. as an original plant and Melia bark, a galenical obtained from bark of Melia toosendan Sieb. et Zucc. as an original plant can also be employed.
Midazolam HCl syrup is a benzodiazepine and is a Schedule IV controlled substance that can produce drug dependence of the diazepam-type. Therefore, midazolam HCl syrup may be subject to misuse, abuse and addiction. Benzodiazepines can cause physical dependence. Physical dependence results in withdrawal symptoms in patients who abruptly discontinue the drug. Withdrawal symptoms (ie, convulsions, hallucinations, tremors, abdominal and muscle cramps, vomiting and sweating), similar in characteristics to those noted with barbiturates and alcohol have occurred following abrupt discontinuation of midazolam following chronic administration. Abdominal distention, nausea, vomiting, and tachycardia are prominent symptoms of withdrawal in infants.

The handling of midazolam HCl syrup should be managed to minimize the risk of diversion, including restriction of access and accounting procedures as appropriate to the clinical setting and as required by law.