anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To remove scarcely water-soluble substance from hot-water extract of volvariella volvacea and to easily obtain a strong antitumor material having extremely low toxicity in large quantity, by treating the hot-water extract with two kinds of ultrafiltration membranes having different fractional molecular weights. CONSTITUTION:Volvariella volvacea is crushed, preliminarily extracted usually with water, etc., and the residue is extracted with hot water e.g. at 80-100 deg.C for 20min-20hr. The obtained extract liquid is treated first with an ultrafiltration membrane having high fractional molecular weight (e.g. a membrane with a fractional molecular weight of 3,000,000-100,000) and then with an ultrafiltration membrane having low fractional molecular weight (e.g. a membrane having a fractional molecular weight of 10,000). A fraction which passes through the membrane having high fractional molecular weight but does not pass through the membrane having low fractional molecular weight is collected, concentrated and freeze-dried to obtain the objective substance.
The intervention will be the randomized selection of anesthetic induction technique to intravenous induction with 2.2 mg/kg propofol. Age 18-55.
INTRODUCTION: Solid organ transplant recipients (SOTRs) are believed to have an increased risk of metastatic cutaneous squamous cell carcinoma (cSCC), but reliable data are lacking regarding the precise incidence and associated risk factors.
METHODS: In a prospective cohort study, including 19 specialist dermatology outpatient clinics in 15 countries, patient and tumor characteristics were collected using standardized questionnaires when SOTRs presented with a new cSCC. After a minimum of 2 years of follow-up, relevant data for all SOTRs were collected. Cumulative incidence of metastases was calculated by the Aalen-Johansen estimator. Fine and Gray models were used to assess multiple risk factors for metastases.
RESULTS: Of 514 SOTRs who presented with 623 primary cSCCs, metastases developed in 37 with a 2-year patient-based cumulative incidence of 6.2%. Risk factors for metastases included location in the head and neck area, local recurrence, size > 2 cm, clinical ulceration, poor differentiation grade, perineural invasion, and deep invasion. A high-stage tumor that is also ulcerated showed the highest risk of metastasis, with a 2-year cumulative incidence of 46.2% (31.9%-68.4%).
CONCLUSIONS: SOTRs have a high risk of cSCC metastases and well-established clinical and histologic risk factors have been confirmed. High-stage, ulcerated cSCCs have the highest risk of metastasis.
The present invention relates to the fusion technology of cell-derived vesicles and liposomes, and hybrid nanoparticles fabricated by the fusion technology, wherein the hybrid nanoparticles can exhibit both a specific tissue-targeting function and a drug delivery function. Specifically, the present inventors have discovered optimal conditions for effectively fusing cell derived vesicles and liposomes. Under the conditions, it is possible to fuse active substance-expressing cell-derived vesicles to drug-encapsulated liposomes to produce hybrid nanoparticles possessing the functions of both of them, that is, dual-functional hybrid nanoparticles. Thus, the present invention allows the fabrication of a wide range of hybrid nanoparticles depending on the purpose. In particular, hybrid nanoparticles fabricated by fusing cell-derived vesicles containing tumor antigen-specific chimeric antigen receptors to liposomes carrying photosensitizers can effectively target cancer cells through the chimeric antigen receptors and can destroy cancer cells by generating reactive oxygen species in response to light stimulation by the photosensitizers. Therefore, the hybrid nanoparticles according to the present invention can effectively target the intended tissues and deliver drugs through the combination of various cell-derived vesicles and liposomes and are expected to be a promising therapeutic platform that can be utilized as drug carriers and therapeutic agents in various fields.
Hyoscyamine sulfate is effective as adjunctive therapy in the treatment of peptic ulcer. It can also be used to control gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. May be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis. For use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and functional gastrointestinal disorders. Also used as adjunctive therapy in the treatment of neurogenic bladder and neurogenic bowel disturbances (including the splenic flexure syndrome and neurogenic colon). Hyoscyamine sulfate is indicated along with morphine or other narcotics in symptomatic relief of biliary and renal colic; as a “drying agent” in the relief of symptoms of acute rhinitis; in the therapy of parkinsonism to reduce rigidity and tremors and to control associated sialorrhea and hyperhidrosis. May be used in the therapy of poisoning by anticholinesterase agents.
Participants will receive Negative Pressure Wound Therapy (NPWT) after surgery and wear the NPWT until postop day 3. NPWT dressing will be removed and a new NPWT will be replaced until Postop day 7, where NPWT dressing will be removed.
Cancer of the esophagus has a poor long term prognosis as well as high perioperative morbidity. Pulmonary complications play thereby a major role. The standard procedure is either a combined transabdominal/transthoracic approach, which allows better visualisation of the tumor and more radical surgery (which may increase R0 resections and consequently overall survival) or a blunt transhiatal technique. In Zurich, Basel and Lucerne, the combined technique is the standard procedure. The combined surgical approach, pre-existing pulmonary disorders, poor nutritional status and the release of pro-inflammatory cytokines may be important contributing factors to pulmonary complications such as pneumonia, atelectasis, pleural effusions and the Acute Respiratory Distress Syndrome (ARDS). N-Acetylcysteine (NAC) has been shown to have direct and indirect oxygen scavenging abilities. In severe sepsis and acute respiratory distress syndrome, positive effects of NAC on morbidity and mortality were discovered. Aim of this study is to assess the influence of NAC on morbidity, oxygenation parameters and cytokine levels.

According to power analysis, 90 patients have to be included in the trial. A multicenter approach was chosen to finish the study within 3 years. Respective to the average number of operations per institution and year, the following distribution is planned: Triemli Hospital 40, University Hospital Basel 30, Kantonsspital Lucerne 20. Inclusion criteria for this trial are patients undergoing thoraco-abdomino-cervical or abdomino-thoracic esophagectomy for cancer between 20 and 90 years and given informed consent. Exclusion criteria are known allergy or hypersensitivity to NAC and pregnancy. Patients are randomised to receive either high dose N-Acetylcysteine administered perioperatively and postoperatively for three days (150mg/kg perioperatively and 50mg/kg days 1-3) or placebo (glucose 5%).

Pre-, peri- and postoperatively cytokines (IL-1, IL-1ra, IL-6, IL-8, IL-10, TNF-α), are quantified by enzyme-linked immuno assay (ELISA) from blood, broncho-alveolar lavage and lavage of pleural space. Leucocytes, C-reactive protein, Procalcitonin and oxygenation parameters (arterial blood gas analyses = ABGA) are regularly measured. Morbidity and mortality is assessed. Furthermore, all patients are asked to complete a quality of life questionnaire (EORTC QLQ-OES18 and 30, SF-36) before and after the operation (12, 24, 36 months post-op).
The intervention group will be give metformin 500 mg orally three times daily in addition to standard of care. The estimated number to be enrolled are 207 patients.
The invention comprises bipyridinium salts of formula <FORM:1041028/C2/1> wherein the anion stands for the anion of an anticoccidial sulphonamide derivative, and the preparation thereof by the interaction of a compound of the formula <FORM:1041028/C2/2> wherein Y is an anion, other than an anion derived from sulphonamide derivatives, with a salt of an anticoccidial sulphonamide derivative, but excluding paraquat salts thereof.ALSO:Veterinary compositions suitable for the treatment of coccidiosis comprise one or more pyridine derivatives of the formula:- <FORM:1041028/A5-A6/1> wherein X stands for an anion, together with an inert non-toxic diluent or carrier. The anion may be a halide or methosulphate anion or an anion derived from an anticoccidial sulphonamide derivative e.g. sulphadimidine, sulphadiazine, sulphapyridine, sulphathiazole, sulphamilamide, sulphaquinoxaline or N-41-acetylaminobenzene-sulphonyl-4-nitroamiline. The compositions may contain one or more known anticoccidial agents e.g. the above specified sulphonamides, or salts thereof, 3-5-dimitrobenzamide, 2-methyl-3, 5-dimitrobenzamide or amprolium. The veterinary compositions may be in the form of aqueous solutions, solution tablets, pre-mix compositions or medicated foodstuffs, and are administered orally. The invention also comprises compositions consisting of one or more of the above pyridine derivatives and one or more known anticoccidial agents.
PURPOSE: Ferment oriental medicine food and a manufacturing method thereof are provided to offer an effect on the treatment of depression effective microorganisms and an herbal medicine. CONSTITUTION: Select herbal medicines, and wash off contaminations. Dry each washed herbal medicine until the moisture is reduced into1-10%, and pulverizing the herbal medicines to obtain powder. Mix each herbal medicine and an effective microorganism compound with molasses or sugar, and water in a certain ration, and ferment the mixture. Dry each fermented herbal medicine to obtain powder. Mix the dried herbal medicine powder with water in a certain ration, and knead the mixture. Mold fermented herbal medicine powder batter into a ring shaped tablet using a tablet producer. Dry the ring shaped tablet with natural air or hot air. Mix the herbal medicins, molasses or sugar, effective microorganisms, and water in a weight ratio of 10:1:1:30. The herbal medicines are composed of 10-50% of beans, 1-10% of Rubus coreanus fruit, 1-10% of sweet potato, 1-10% of morus bark, 1-10% of mint, 1-10% of lycium, 1-10% of chrysanthemum, 1-10% of gaststickia, 1-10% of licorice, 1-10% of Paeonia japorica, 1-10% of Holen rubra, 1-10% of earth crust, 1-15% of Atractylodis Lanceae Rhizoma, 1-10% of Atractylodes japonica root, 1-10% of cnidium, 1-10% of gardenia seeds, 1-10% of Korean angelica root, 1-10% of forsythia fruit, 1-10% of Chinese yeast, 1-10% of barberry root, 1-20% of ginger, and 1-15% of Aurantii nobilis Pericarpium. The effective microorganisms is obtained by mixing 1-90wt% of lactobacillus, 1-90wt% of yeast fungus, and 1-90% of yeast fungus and photosynthetic bacteria mixture, and mixing the microorganism mixture with molasses or sugar in a weight proportion of 1:1 culturing without any supply of media under 20-40 deg. C for 3-6 months.
BACKGROUND: Plant microbiota contributes to plant growth and health, including enhancing plant resistance to various diseases. Despite remarkable progress in understanding diseases resistance in plants, the precise role of rhizosphere microbiota in enhancing watermelon resistance against soil-borne diseases remains unclear. Here, we constructed a synthetic community (SynCom) of 16 core bacterial strains obtained from the rhizosphere of grafted watermelon plants. We further simplified SynCom and investigated the role of bacteria with synergistic interactions in promoting plant growth through a simple synthetic community.
RESULTS: Our results demonstrated that the SynCom significantly enhanced the growth and disease resistance of ungrafted watermelon grown in non-sterile soil. Furthermore, analysis of the amplicon and metagenome data revealed the pivotal role of Pseudomonas in enhancing plant health, as evidenced by a significant increase in the relative abundance and biofilm-forming pathways of Pseudomonas post-SynCom inoculation. Based on in vitro co-culture experiments and bacterial metabolomic analysis, we selected Pseudomonas along with seven other members of the SynCom that exhibited synergistic effects with Pseudomonas. It enabled us to further refine the initially constructed SynCom into a simplified SynCom comprising the eight selected bacterial species. Notably, the plant-promoting effects of simplified SynCom were similar to those of the initial SynCom. Furthermore, the simplified SynCom protected plants through synergistic effects of bacteria.
CONCLUSIONS: Our findings suggest that the SynCom proliferate in the rhizosphere and mitigate soil-borne diseases through microbial synergistic interactions, highlighting the potential of synergistic effects between microorganisms in enhancing plant health. This study provides a novel insight into using the functional SynCom as a promising solution for sustainable agriculture. Video Abstract.
Hayman suture is a common technique for uterine compression to stop bleeding due to uterine atony. Hayman described placement of two to four vertical compression sutures from the anterior to posterior uterine wall without hysterectomy. It is usually employed to overcome uterine atoy dıring cesarean section. However, since the technique is relatively new, data on its safety and efficacy arelimited to a few case reports. several complications including cavity obliteration, blood entrapment and infections have been described. However, data regarding the ovarioan function is lacking.
PROBLEM TO BE SOLVED: To provide an agent for the treatment and prevention of hepatitis by using powder of Lactobacillus brevis as a component. SOLUTION: Powder of Lactobacillus brevis prepared by the concentration. and freeze-drying of a cultured liquid of Lactobacillus brevis is used as a component of the agent. The bacterial cell powder can be produced by dissolving yeast extract, glucose, potassium dihydrogen phosphate, sodium hydrogen phosphate, sodium chloride, sodium hydroxide and defatted soybean extract liquid in water under heating, adding precipitated calcium carbonate, adjusting the pH, sterilizing with high-pressure steam, adding a seed of Lactobacillus brevis to the obtained medium, culturing the seed cell, concentrating or centrifugally separating the produced cells and freeze-drying the separated cells. The cells are prepared in the form of a preparation containing about 10<8> to 10<9> cells/g and administered by oral administration.  An oral agent for the treatment and prevention of hepatitis C and free from side effect can be produced without using expensive interferon.
Participants with mTBI, as well as healthy control participants, will be invited to participate in up to two study visits. Both visits will occur at the University of Minnesota's Center for Magnetic Resonance Research (CMRR). The first study visit will entail (1) interviews to determine the presence of (and, if present, the severity of) oculomotor difficulties such as convergence insufficiency, and (2) behavioral measures (e.g., visually track a moving dot) to assess skill at allocating spatial attention. For participants who have not before participated in an MRI study at the CMRR, a 15-minute scan to acquire research-quality anatomical images of the brain will be acquired at the end of the first visit. A subset of the approximately 88 participants who participate in Visit 1 will be invited to participate in Visit 2. Visit 2 will be dominated by a 90-minute scanning session in the 7 Tesla scanner, during which participants will perform a 10-minute spatial attention task and a 10-minute eye movement task, and high-resolution diffusion tensor imaging data will be acquired while participants enjoy the movie of their choice in the scanner.
Then, at the 4th hour, 8th hour and 12th hour of the surgery, the patients in the coffee group received 10 gr. granulated coffee.
BACKGROUND: Perceived weight discrimination is associated with increased risk for chronic diseases and reduced life expectancy. Nevertheless, little is known about perceived weight discrimination in racial, ethnic, and sexual minority groups or in individuals at the intersections of those groups. The goal of this study was to identify sociodemographic predictors of perceived weight discrimination.
SUBJECTS/METHODS: A diverse sample of adults (37% Black/African American, 36% Latino, 29% sexual minority) with a body mass index (BMI) ≥ 18.5 kg/m2 were recruited from a national US panel to complete an online survey (N = 2454). Perceived weight discrimination was assessed with the Stigmatizing Situations Survey-Brief (SSI-B). Using hierarchical linear regression analysis, SSI-B scores were predicted from the four sociodemographic characteristics of interest (gender, race, ethnicity, and sexual orientation) while controlling for BMI, age, education, and income (Step 1). At Step 2, all two-way interactions between the four sociodemographic characteristics were added to the model.
RESULTS: At Step 1, higher SSI-B scores were observed for Latino (vs. non-Latino) adults, sexual minority (vs. heterosexual) adults, younger (vs. older) adults, adults with higher (vs. lower) levels of education, and adults with higher (vs. lower) BMI. At Step 2, race interacted with gender, ethnicity, and sexual orientation to predict SSI-B scores such that relatively higher scores were observed for non-Black women, Black men, adults who identified as Black and Latino, and non-Black sexual minority adults.
CONCLUSIONS: Perceived weight discrimination varied across sociodemographic groups, with some subgroups reporting relatively high frequency. Black race appeared to be protective for some subgroups (e.g., Black women), but risk-enhancing for others (e.g., Black men, individuals who identified as Black and Latino). Additional research is needed to identify specific factors that cause certain sociodemographic groups -and indeed, certain individuals-to perceive higher levels of weight discrimination than others.
This study examined the impact of person-centered communication on bereaved young adults' physiological stress responses when they talked about the death of their parent. Heart rate variability - indexed by the standard deviation of the normal-to-normal intervals (SDNN), the root mean square of successive differences (rMSSD), and the heart rate variability index (HRVi) - was monitored before, during, and after the interaction as an objective measure of stress reactivity and recovery. The final sample included 69 subjects, and they conversed with research confederates who provided varying levels of person-centered support. The results showed that participants who received highly person-centered support experienced faster stress recovery, as indicated by increased HRVi, compared to those who received moderately or low person-centered support. Bereaved adults' SDNN during the interaction was positively associated with subjective evaluations of cognitive reappraisal, emotional improvement, and support quality. The discussion highlights the significance of supportive interactions on physiological, psychological, and emotional well-being.
Hypotension is common after induction of general anesthesia, with an incidence of 9% to 90%. Hypotension after induction of anesthesia may increase the risk of cardiovascular and cerebrovascular accidents, postoperative cognitive dysfunction, as well as increase the risk of postoperative acute myocardial injury and increase the mortality rate during hospitalization. The aim of this study is to establish an assessment method that can effectively predict hypotension after induction of anesthesia, so as to prevent possible harm to patients from perioperative hypotension. The study is planned to measure the peak flow velocity variation and corrected blood flow time of the carotid artery, the diameter and cross-sectional area of the inferior vena cava by applying ultrasound before anesthesia, and record the blood pressure and heart rate before induction of anesthesia, and the blood pressure and heart rate per minute within 10 minutes after induction of tracheal intubation. The mean arterial pressure (MAP) was recorded as the basal value before induction of anesthesia. After induction of anesthesia, MAP \< 60 mmHg, or a decrease of more than 30% of the basal value, was defined as the occurrence of hypotension.
Alternative or complementary therapies are widely used by patients with epilepsy. St. John's Wort is one of the most popular herbal dietary supplements with a variety of claims including mood elevation and stabilization, stress relief, anti-viral effects, and enhancement of the immune system. We have previously demonstrated that treatment with St. John's Wort for 14 days does not induce the clearance of carbamazepine under steady state conditions of autoinduction of carbamazepine clearance. One proposed mechanism for this lack of effect is that St. John's Wort is not sufficiently potent to further induce previously induced CYP3A4 enzyme activity. The purpose of this study is to investigate the effect of St. John's Wort on single dose carbamazepine pharmacokinetics under conditions of uninduced CYP3A4. To evaluate this potential drug interaction, as well as the effect of St. John's Wort on epoxide hydrolase activity, eight normal healthy subjects will be enrolled into this pharmacokinetic study. Subjects will take a single 400 mg dose of carbamazepine followed by serial blood sampling over 72 hours for carbamazepine and carbamazepine epoxide plasma concentrations. Subjects will then begin taking a standardized formulation of St. John's Wort three times daily with meals for two weeks. Following 2 weeks of St. John's Wort subjects will then again take a single 400 mg dose of carbamazepine and have serial blood samples collected for carbamazepine and carbamazepine epoxide plasma concentrations. The total carbamazepine and carbamazepine epoxide exposure (AUC), oral clearance (CL/F), and maximal concentrations (Cmax) will be compared between treatment phases to characterize the potential drug interaction.