anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Response disequilibrium is the perturbation of unconstrained behavior with a contingency. For example, the imposition of advertisements before or after viewing TikTok videos. The purpose of this laboratory analogue was to determine the effects of two such response disequilibrium conditions: (1) which required participants to view 5 s increments of advertisements to access 2 s increments of TikTok videos and (2) which required participants to view 5 s increments of TikTok videos to access 15 s increments of advertisements. The disequilibrium condition in (1) is called a response deficit due to the restricted access to TikTok videos relative to baseline while (2) is called a response excess due to the overabundance of advertisements relative to baseline. Additionally, participants had access to a third activity that was freely available throughout. Participants could browse images of TikTok video thumbnails while in deficit and excess. As predicted, participants increased their viewing of advertisements when TikTok was in deficit and decreased their viewing of TikTok when advertisements were in excess. Furthermore, some participants substituted TikTok with browsing during the excess of advertisements. This investigation has implications for a behavioral economic analysis of social media use and the contingency management of time spent on these platforms.
A system and a method for smart information recognition for user health identification are disclosed. The system and the method comprise a display unit, a color code detection unit, an image filter, an optical character recognition unit, a code detection unit and an elimination unit. The display unit contains a user information. The color code detection unit is associated with the display unit to split at least one of the user information by analyzing at least three colors in an image. The image filter detects at least one of the user's information. Further, the optical character recognition unit recognizes a text of the user information. The code detection unit detects an image code and the elimination unit is used for eliminating a binary object that is close to an image border. The proposed system and method ensure complete security to prevent abuse of an individual's personal information.
0.1 to 0.2 mL per kg body weight (0.045 to 0.09 mL per pound body weight). Inject methylene blue intravenously very slowly over a period of several minutes.

Methylene blue must be injected intravenously very slowly over a period of several minutes to prevent local high concentration of the compound from producing additional methemoglobin. Do not exceed recommended dosage.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

To report SUSPECTED ADVERSE REACTIONS, contact: Cameron Pharmaceuticals, LLC at 1-888-296-9383 (or FDA 1-800-FDA-1088) or through email at www.fda.gov/medwatch.
Patients with stable coronary artery disease (SCAD) planned for elective angiography. If PCI is to be performed and if the responsible physician decides to administrate a loading dose of 180 mg ticagrelor, written informed consent will be obtained before loading dose and blood sampling.
Esophageal cancer is one of the common and highly fatal malignant tumors, and its incidence rate is increasing every year, and most of them are in the middle and advanced stages when diagnosed. Surgery is the standard treatment for the eradication of esophageal cancer, which can effectively reduce the mortality rate and improve the survival rate, but the patients often experience gastrointestinal discomfort after surgery, which impedes the intake of nutrients and the body's recovery. The purpose of this study was to investigate the effectiveness of acupressure in improving the postoperative gastrointestinal discomfort in patients with esophageal cancer. An experimental study design was adopted, and patients were assigned to the experimental group and the control group in a time-divided manner. The experimental group was assigned to the experimental group and the control group in a time-separated manner. The experimental group received regular care from the first day to the fifth day after the patients were transferred from the intensive care unit to the hospital ward after the surgery, and they received acupressure at the Neiguan point of the upper limbs and the four acupoints of the foot Sanli of the lower limbs twice a day for 3 minutes each, for a total of 12 minutes; while the control group received regular care in the first day of the study. In this study, the gastrointestinal symptoms of the experimental group before and after acupressure were collected and compared with those of the control group, in order to verify the effectiveness of acupressure in improving gastrointestinal symptoms during postoperative nutritional support for jejunostomy.
Risk-reducing bilateral salpingo-oophorectomy (RRSO) is recommended for breast cancer gene 1 (BRCA1) and 2 (BRCA2) mutation carriers. A major consequence of RRSO is surgical menopause associated with severe menopausal symptoms, mostly genitourinary complaints. Due to the inherent breast cancer risk, estrogen-based therapies are generally avoided in these patients. So far, the non-hormonal approaches available are not efficient to successfully treat the disabling vaginal atrophy-related symptoms. In regenerative medicine, mesenchymal stem cells (MSC) are the most frequently used cell type due to their remarkable and regenerative characteristics. Therapies based on MSC have revealed positive outcomes regarding symptoms and signs associated with vaginal atrophy by promoting angiogenesis, vaginal restoration, and the proliferation of vaginal mucosa cells. Menstrual blood-derived stem cells (MenSC) are a novel source of MSC, with promising therapeutic potential directly linked to their high proliferative rates; low immunogenicity; non-invasive, easy, and periodic acquisition; and almost no associated ethical issues. In this review, we update the current knowledge and research regarding the potential value of previously preserved MenSC in the therapy of vaginal atrophy among BRCA mutation carriers subjected to RRSO.
Although many schizophrenia patients currently take oral antipsychotic medications, it is estimated that up to 75% of them have difficulty adhering to the daily oral regimen. Long-acting injectable formulations may eliminate the need for daily medication and enhance patient compliance with the treatment regimen. This is an open-label, randomized, Phase III trial in patients with schizophrenia. One treatment group receives 25 to 50 mgs of long-acting risperidone, formulated for intramuscular injections, at study initiation and again after 2 weeks, while phasing out any previous antipsychotic medication during the initial 3 weeks of the study. Continuing in the treatment phase, long-acting injections are administered once every 2 weeks through Week 24, and post-treatment observation is performed for 6 weeks (total study duration of 30 weeks). Patients in the other treatment group take oral risperidone tablets, 2 to 6 mgs daily, from study initiation for 24 weeks. Post-treatment observation continues for 1 week for this group (total study duration of 25 weeks). Assessments of effectiveness made at specified intervals during treatment include Positive And Negative Syndrome Scale (PANSS), a scale for the measurement of symptoms of schizophrenia; Clinical Global Impression - Severity (CGI-S), a measure of overall severity of illness, and Clinical Global Impression - Changes (CGI-C); as well as, Brief Psychiatric Rating Scale (BPRS). Safety evaluations include the incidence of adverse events throughout the study; inspection of the injection site at times of treatment; Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS), vital signs (pulse, blood pressure, temperature), and laboratory tests (hematology, biochemistry, urinalysis) at monthly intervals. The study hypothesis is that treatment with long-acting risperidone injections is not inferior to oral risperidone, as measured by changes in PANSS total score from baseline through endpoint (24 weeks), in patients with schizophrenia and is generally well-tolerated. Risperidone, long-acting formulation for intramuscular injections (25 milligrams\[mg\] to 50mg, maximum), given biweekly through 24 weeks. Oral risperidone (2mg/day to 6mg/day \[maximum\]) administered daily for 24 weeks.
The control group in this trial will be the best usual care, using the standard Electronic Health Records available to the practice. Our understanding of what "best usual care" is for people with multimorbidity is informed by qualitative research in an earlier stage of this project. Our results suggest that healthcare professionals often provide disease-driven care. When faced with multiple healthcare problems, they prioritise based on 1) patient complaints; 2) which condition is less well controlled; or 3) which condition is more likely to adversely impact on patient Health Related-Quality of life. General practitioners and primary care nurses are often not familiar with the Goal-Oriented Care model. However, they already try to implement some of its principles such as identifying patient goals and supporting shared decision making.
Participants will be administer the standard caffeine recommendation (200mg/2 hr. up to 800mg/24 hr.) using caffeinated and non-caffeinated gum during both nights of Phase 2.
Fifty-three individuals (23 females and 30 males) with CMLBP participated in this single blind randomised clinical trial. Consecutive participants were recruited from the outpatient Physiotherapy clinic of the Aminu Kano Teaching Hospital, Kano, Nigeria and were randomly assigned to one of two exercise groups: Lumbar Stabilisation Group (LSG; n = 27) or Treadmill Walk Group (TWG; n = 26). However, 50 participants, (LSG: n = 25; and TWG: n = 25) completed the eight week study. Participants in the LSG had lumbar stabilisation exercises using McGill protocol while those in the TWG had walking exercise on a treadmill using the Bruce protocol. Treatment was applied three times weekly for eight weeks. Outcomes assessed at baseline and end of eighth week of study were: Pain Intensity (PI) using Visual Analogue scale, Functional Disability (FD) using Oswestry Disability Index Questionnaire; and Multifidus Muscle Activation (MMA) level using a surface electromyography machine. Data were analysed using descriptive statistics, paired and independent t-tests at α0.05.
The invention comprises a stable pyrogenfree mono alkali metal salt of glutathione having at most 6 per cent by weight of water of hydration; such salt has a pH in aqueous solution of 5.5-6.8, preferably 6.0-6.3.  The salt is made by passing an aqueous solution of glutathione through a cation exchange resin to remove traces of heavy metals, adding alkali to bring the pH within the above range, treating the solution with activated carbon to remove pyrogens, filtering off the carbon, passing the filtrate through a bacterial filter and concentrating it to a dry powder, e.g. by lyophilization or precipitation with alcohol.  The last step may be carried out in such a way as to form a dry porous plug in a vial.  A typical specimen of mono-sodium glutathione prepared above has N 11.8-12.8 (e.g. 12.0), S 9.0-9.8 (e.g. 9.2), Na 6.0-7.3 (e.g. 6.9) parts by weight of non-aqueous components, N/S ratio 1.30-1.32 and water of hydration 3.6 per cent.  The step of removing pyrogens is preferably carried out by adding 5-20 per cent of activated carbon and stirring at room temperature for 15-60 minutes.  In the examples: (1) 100 g. of glutathione are dissolved in 500 mol. of distilled water at 30 DEG C. and passed through a cation exchange resin; sodium hydroxide is added to pH 6.0, 15.g. of activated carbon stirred in for 20 minutes, the mixture filtered, the filtrate passed through a bacterial filter, sterile pyrogen-free water added to bring the concentration of glutathione to 150 mg./mol., the solution frozen and lyophilized in the vial and capped under sterile conditions; (2) 1 kg. of glutathione is dissolved in 4.5 1. of water, passed through a cation exchange resin, 20 per cent caustic soda added, with cooling, to pH 6.1, 150 g. of activated carbon added, stirred and filtered; the filtrate is passed through a bacterial filter and added to 100 l. of de-pyrogenized anhydrous alcohol; the resultant precipitate is filtered off and dried.  The alkali used may be carbonate instead of hydroxide.  The potassium, ammonium and lithium salts may be prepared similarly.
The invention discloses a method used for painless removing of kidney stone with traditional Chinese medicines, and a medicine taking method. A traditional Chinese medicine decoction is composed of herba lysimachiae, herba taraxaci, pyrrosia lingua, herba dianthi, medulla Junci, herba polygoni avicularis, corn stigma, pleurotus ostreatus, jasminum laurifolium, syzygium buxifolium, all-grass of neolepisorus ovatus, herba lophatheri, and juniperus rigida fruit. A medicine powder is composed of bryozoatum, talcum, chingma abutilon seed, all-grass of lygodium japonicum, semen plantaginis, Chinese waxgourd seed, membrane of goose gizzard, turtle shell, rhizoma alismatis, and rheum officinale. The traditional Chinese medicines are prepared based on traditional Chinese medicines theories and combination of secret prescription handed down from ancestors and folk prescriptions, under experience guidance of clinical practice application of a large amount of clinical cases, from high quality genuine medicinal materials at a certain ratio. The traditional Chinese medicines are capable of clearing heat and promoting dieresis, nourishing kidney and enriching qi, and removing calculus. Curative effects are excellent and are achieved quickly; no pain or side effect is caused; and a preparation method is simple. The traditional Chinese medicines are composed of the traditional Chinese medicine decoction and the medicine powder. A medicine soup is obtained via decoction of the traditional Chinese medicine decoction; one medicine portion of one day is divided into two parts; after breakfast and supper, the obtained medicine soup is warmed, the medicine powder is added for mixing, an obtained product is taken by patients, and a large amount of warm water is drunk by the patients after taking of the product. Exercise is beneficial for calculus removing. One treatment course takes 10 days.
Since many of the adverse events associated with quinine are dose-related, it is important to consider how varying degrees of renal dysfunction alter quinine pharmacokinetics possibly warranting dosage adjustment in these patients. This study will compare the pharmacokinetics of quinine in patients with normal, mild or moderate renal impairment. Eighteen non-smoking males and female volunteers between 18-65 years of age weighing at least 60 kg with BMI between 18- 40 kg/m2 will be divided into 3 groups of 6 subjects each based on renal function as defined (6 normal, 6 mild impairment, 6 moderate impairment). Subjects will be confined to the study unit during the entire 5 day study period beginning on the evening of Day -3. To confirm renal function classification, creatinine clearance will be measured via 24-hour urine collection from 7am Day -2 until 7am Day -1. On day 1, after a fast of at least 8 hours, each patient will receive a single 648 mg dose of quinine sulfate. Blood and urine samples will be collected at times sufficient to adequately define the pharmacokinetics of quinine and its active metabolite, 3'-hydroxyquinine) in the three study groups. Subjects will be monitored regarding adverse effects throughout study participation.
Sedation and analgesia use in tumor ablation is a necessary part of the procedure. However, the optimal medicine for sedation and analgesia for tumor ablation remains controversial. Currently, morphine is a traditional opioid used for pain control and anaesthesia. As no publications have compared the anaesthetic and analgesic effects between nalbuphine and morphine during tumor ablation, this trial aims to compare the analgesic efficacy and safety of nalbuphine and morphine for perioperative tumor ablation. In addition, other endpoints in term of perioperative analgesia indexes, such as ablation time, daily dose, analgesia satisfaction, quality of life, and safety, etc. will be compared.
A conserved cluster of oligomannose glycans on gp120 has been identified as the epitope recognized by the broadly HIV-1-neutralizing monoclonal antibody 2G12. Oligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendritic cells. Multivalency is fundamental for carbohydrate-protein interactions, and mimicking of the high glycan density on the virus surface has become essential for designing carbohydrate-based HIV vaccines and antiviral agents. Synthesis of oligomannose dendrons, which display multivalent oligomannoses in high density, and characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay is disclosed. These glycodendrons inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC 50  in the nanomolar range. A second-generation Man 9  dendron was identified as a potential immunogen for HIV vaccine development and as a potential antiviral agent.
PURPOSE: Accurate identification of primary breast cancer and axillary positive-node response to neoadjuvant chemotherapy (NAC) is important for determining appropriate surgery strategies. We aimed to develop combining models based on breast multi-parametric magnetic resonance imaging and clinicopathologic characteristics for predicting therapeutic response of primary tumor and axillary positive-node prior to treatment.
MATERIALS AND METHODS: A total of 268 breast cancer patients who completed NAC and underwent surgery were enrolled. Radiomics features and clinicopathologic characteristics were analyzed through the analysis of variance and the least absolute shrinkage and selection operator algorithm. Finally, 24 and 28 optimal features were selected to construct machine learning models based on 6 algorithms for predicting each clinical outcome, respectively. The diagnostic performances of models were evaluated in the testing set by the area under the curve (AUC), sensitivity, specificity, and accuracy.
RESULTS: Of the 268 patients, 94 (35.1 %) achieved breast cancer pathological complete response (bpCR) and of the 240 patients with clinical positive-node, 120 (50.0 %) achieved axillary lymph node pathological complete response (apCR). The multi-layer perception (MLP) algorithm yielded the best diagnostic performances in predicting apCR with an AUC of 0.825 (95 % CI, 0.764-0.886) and an accuracy of 77.1 %. And MLP also outperformed other models in predicting bpCR with an AUC of 0.852 (95 % CI, 0.798-0.906) and an accuracy of 81.3 %.
CONCLUSIONS: Our study established non-invasive combining models to predict the therapeutic response of primary breast cancer and axillary positive-node prior to NAC, which may help to modify preoperative treatment and determine post-NAC surgery strategy.
The present application relates to methods and devices for estimating bladder status. In particular, to methods and devices for estimating bladder status with respect to the likelihood of an impending voiding of the bladder. The device performs a computer-implemented method of estimating bladder status using a bladder monitor that collects bladder data (e.g., using ultrasound) and transmits the bladder data to a data processor for algorithmic conversion to bladder status. Such algorithms may be trained and tuned to a particular human bladder. After establishing the bladder status based on the originally profound bladder data, the data processor may then trigger an alarm signal in case the bladder status meets certain criteria indicating an upcoming voiding event. Such a trigger signal may be used to alert nocturnal enuresis patients to an impending voiding so that they may be awakened before any bed wetting occurs.
NEW MATERIAL:A compound of formulaI(R is 9-21C aliphatic hydrocarbon group). EXAMPLE:1,5-Dimethyl-2-isopentylhexyl myristate. USE:Useful as a component in cosmetics or drugs for external use in direct contact with the skin or an oily component incorporated with an oil or emulsion, e.g. a medicine, in the liquid state at room temperatue, and having a lower cloud point than expected from the molecular weight without giving the irritation to the skin surface even in continuous use, and having improved stability in air for the ester of a saturated fatty acid. PROCESS:1,5-Dimethyl-2-isopentylhexanol of formula II or a reactive derivative thereof and a 10-22C fatty acid or a reactive derivative thereof, e.g. an acid halide, are reacted with a dehydrohalogenating agent, e.g. pyridine, in a solvent, e.g. benzene, at 50-100 deg.C under heating and stirring to give the aimed compound of formulaI.
BACKGROUND: Biomarkers for predicting response to the immunotherapy and chemotherapy combination in breast cancer patients are not established. In this study, we report exploratory genomic and transcriptomic analyses of pretreatment tumor tissues from patients enrolled in phase II clinical trial of a combination of eribulin and nivolumab for HER-2-negative metastatic breast cancer (MBC) (KORNELIA trial, NCT04061863).
METHODS: We analyzed associations between tumor molecular profiles based on genomic (n = 76) and transcriptomic data (n = 58) and therapeutic efficacy. Patients who achieved progression-free survival (PFS) ≥ 6 months were defined as PFS6-responders and PFS6-nonresponders otherwise.
FINDINGS: Analyses on tumor mutation burden (TMB) showed a tendency toward a favorable effect on efficacy, while several analyses related to homologous recombination deficiency (HRD) indicated a potentially negative impact on efficacy. Patients harboring TP53 mutations showed significantly poor PFS6 rate and PFS, which correlated with the enrichment of cell cycle-related signatures in PFS6-nonresponders. High antigen presentation gene set enrichment scores (≥ median) were significantly associated with longer PFS. Naïve B-cell and plasma cell proportions were considerably higher in long responders (≥ 18 months).
INTERPRETATION: Genomic features including TMB, HRD, and TP53 mutations and transcriptomic features related to immune cell profiles and cell cycle may distinguish responders. Our findings provide insights for further exploring the combination regimen and its biomarkers in these tumors.
Brain stimulation using repetitive transcranial magnetic stimulation (rTMS) will be given after a deliberate memory re-activation, using repetitive pulses at 1Hz frequency for 15 minutes, once a week over 5 weeks. The scalp stimulation area will be determined based on a resting state fMRI scan identifying a cortical area that is most strongly functionally connected to the left hippocampal target of each patient.
A user interface that integrates and uniformly presents to a healthcare consumer all or most of the consumer's health, health-related, and financial data is described. The interactive user interface is comprised of multiple dashboards which all have a generally uniform appearance and contain one category of health or financial data. A user can configure the size of each dashboard and its placement on the screen. By doing so, a healthcare consumer can view in one screen display data from multiple sources all relating to healthcare. The user interface is presented to a user by a service provider as the interface or window into a healthcare data management system provided by the service provider. The service provider itself stores and manages some of the consumer's health data, such as biometnc readings.