anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sotalol hydrochloride has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. Sotalol hydrochloride is a racemic mixture of d-and l-sotalol. Both isomers have similar Class III antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity. The beta-blocking effect of sotalol is non­-cardioselective, half maximal at about 80 mg/day and maximal at doses between 320 and 640 mg/day. Sotalol does not have partial agonist or membrane stabilizing activity. Although significant beta-blockade occurs at oral doses as low as 25 mg, significant Class III effects are seen only at daily doses of 160 mg and above. 

Information related to an electrophysiologic effect in pediatric patients is approved for Berlex Laboratories’ sotalol hydrochloride tablets. However, due to Berlex’s marketing exclusivity rights, this drug product is not labeled for pediatric use.
OBJECTIVE: To evaluate the possibility of improving the effectiveness of early postoperative healing in patients after surgical interventions on periodontal tissues due to the topical application of alginate plates with a complex of antimicrobial peptides and cytokines.
MATERIALS AND METHODS: 40 patients who underwent periodontal surgery were examined: operations aimed at bone tissue regeneration; mucogingival operations (elimination of gum recession), corticotomy with osteoplasty, apical surgery. The patients were randomly divided into 2 groups of 20 people (main and control). At the end of the operation, alginate plates with a complex of antimicrobial peptides and cytokines were applied to the surgical intervention area to the main group. Further, 2-3 times a day, it was recommended to apply them independently for 10-14 days, after antiseptic treatment. In the control group, they were limited to double treatment with 0.05% chlorhexidine bigluconate solution daily for two weeks. Follow-up examinations and evaluation of the index of early wound healing, as well as indicators of postoperative pain, bleeding and edema were carried out on day 3, 7, 14.
RESULTS: In all patients in the early postoperative period, positive dynamics of healing were observed, however, in the main group, pain indicators, as well as bleeding and swelling, according to a patient survey, were less pronounced. The early wound healing index was also more positive in the main group - on days 3, 7 and 14 there was a more intense decrease. (1.9 points.,1.5 points., 1.2 points., respectively, and in the control group 2.3 points., 2.1 points., 1.9 points.).
CONCLUSION: Local application of alginate plates with a complex of antimicrobial peptides and cytokines in the early postoperative period allows to improve early wound healing after surgical interventions on periodontal tissues, and can be recommended for use at a dental appointment, as well as for use at home.
PURPOSE: An Aerococcus sp. LK7 and an antibacterial agent containing the same are provided to ensure bacteriosin productiviyt and to be used as a disinfectant or cosmetic products. CONSTITUTION: An Aerococcus sp. LK7 strain LK7(KACC 91604) is isolated from fish gastrointestinal tract and has bacteriosin productivity and antibacterial activity. An antibacterial agent with antibacterial function contains the strain or bacteriosin prepared from the strain. The antibacterial agent is used by being added to feed for fishes or livestock. The bacteriosin has thermal stability.
Dysfunction of HNF4α may lead to disease and an identification of genes targeted by this factor provides insights into mechanisms of disease. In accordance with the invention thirteen new HNF4α target genes were found (C20orf13, KIAA0774, EPS15R, PLCB1, UGTREL1, RSK4, PAK5, FMR2, NEB, NFYC, KCNQ4, PRPF3, TRPC1). These genes were identified by means of molecular biological and molecular genetic methods. The genes code for various biological functions (metabolism, regulation of cell cycle and signal transduction, differentiation, ion channels, mRNA processing, see table A) and are thus important for the therapy of metabolic disorders, diabetic diseases and tumor growth. In the present invention, additionally eleven new HNF4α target genes are described. It was shown that HNF4α and TPRC1 are regulated in animal models of diabetes. Thus, TPRC1 is a candidate gene for the treatment of diabetic nephropathy. The discovery of the above described target genes of HNF4α and their function comprises an enormous potential for the treatment of metabolic discuses including diabetes and diabetic caused diseases and tumor growth.
Kinesiotape will be applied by using two I-bands application technique. It will be applied once a week for 3 to 5 days and total time period of 3 weeks.
The invention provides methods and apparatus for stable generation and delivery of solid nano-particles in aerosols that simultaneously maintain high nano-particle concentration, and which avoid coagulation and agglomeration of the nano-particles. The apparatus includes a Collison nebulizer is in communication with a plenum. The Collison nebulizer includes a port for introducing a helium gas flow into the Collison nebulizer. The plenum includes component(s) for providing flow of uniform axially symmetrical dry air around the nano-particles entrained in the helium gas flow in the plenum. Preferably, the plenum includes an uniformity screen and a reduction in the plenum circumference downstream from the uniformity screen. In some preferred aspects, the invention provides methods of introducing nanoparticles into the lungs of test animals. The present invention allows more than 0.5 mass % of the nano-particles to be deposited in an animal's lungs.
NEW MATERIAL:An azulene derivative consisting of a compound shown by the formulaI(R<1> is lower alkyl), its salt or its amide derivative. EXAMPLE:2-(7-Isopropyl-1-methylazulene-4-yl)propionic acid. USE:Having improved antiphlogistic and analgesic action, useful as an antiphlogistic anodyne. Having low toxicity, a small amount of medication, showing improved effect. PROCESS:7-Isopropyl-1-methylazulene-4-yl acetic acid shown by the formula II, for example, is treated with an organic or inorganic base, or amine in the absence of a solvent or in a proper inert solvent. The prepared salt or amide derivative is reacted with an alkyl halide shown by the formula III (X is halogen), to give a compound shown by the formulaI.
ABSTRACT OF THE DISCLOSURE         The present invention relates to pharmacologically valuable new benzophenonc derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new derivatives have the structural formula   and the pharmaceutically acceptable acid addition salts thereof in which R1 and R2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1-4 carbon atoms; R3 is selected from the group consisting of -COOC3H7, -COOC4H9, -COOC6H5, -C6H5, -?-NHR4, whereby R4 is an aliphatic radical with 1 to 4 carbon atoms or phenyl and Y is an oxygen or sulfur atom: if m is o  R3 13 further selected from the group consisting of -COOCH3 and -COOC2H5; n is an integer selected from 1 and 2 ; and m is an integer selected from 0, 1, 2 and 3, and wherein the rings A and B may be substituted, ring A being substituted preferably with halogen such as chlorine or with nitro, trifluoromethyl, methyl, methoxy or methylmercapto, preferably in the 5 positon.     and ring B being preferably substituted in the 2' position with chlorine or fluorine. The radicals R1 and R2 preferably signify hydrogen or a methyl group, or a n-butyl group in the case of Ring b.       Compounds represented by the above structural formula may be produced by reacting a compound represented by the formula   with a compound having the formula Y - CmH2m - R3, one of X and Y signifying the substituent R2 - NH - and the other signifying a halogen atom, preferably a bromine of chlorine atom, so as to form the above specified benzophenone derivative with the elimination of H - Hal, R1, R2, R3, n and m being as defined above, and the rings A and B being optionally substituted as discussed above.  The hydrogen halide which is eliminated is advantageously bound by the addition of an acid-binding agent, as for example, a molar excess of the amine used in the reaction or, for example, triethylamine, dimethylaniline, potassium or sodium carbonate or sodium bicarbonate.  The reaction is carried out in a suitable solvent, preferably at an elevated temperature, typically the reflux temperature of the solvent used.
Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia, and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.
The invention discloses a pharmaceutical composition. The mol ratio of arginine and ibuprofen is more than 1:1. The pharmaceutical composition is characterized in that the composition exists in an aseptic powder form or in a solution form that the arginine is subjected to acid protonation or is combined with acid to form salt. The invention also discloses a method for preparing the composition. The composition can be used in injection administration in a freeze-dry or non-freeze-dry form and in oral administration, excellent effects of the ibuprofen, such as antipyresis, anti-inflammation and analgesia, are kept, and the incidence rate of common adverse reaction of gastrointestinal tracts and cardiovascular systems of the ibuprofen is reduced to certain extent. Besides, the preparation of the composition is stable, and phenomena that total impurities and foreign matters fail to meet standards during sterilization, degerming and long-term placing are reduced.
BACKGROUND: Ankle-foot orthoses (AFO) can improve gait posture and walking ability in post-stroke patients. However, the effect of AFO on gait parameters in post-stroke patients according to the Brunnstrom stage of stroke recovery of the lower limbs remains unclear. The study aimed to investigate whether stroke patients with different Brunnstrom stages benefit from wearing AFO.
METHODS: Twenty-five post-stroke participants included 18 men (50 ± 13 years) and 7 women (60 ± 15 years). The patients were divided based on Brunnstrom stage III or IV of the lower limbs. All patients underwent the gait and timed up and go (TUG) test using a gait analysis system while walking barefoot or with an AFO. The spatiotemporal and asymmetric parameters were analyzed.
RESULTS: All 25 patients completed the study. Significant differences were observed between barefoot and AFO use in TUG time (P < 0.001) but not walking velocity (P > 0.05). The main effect of the swing time ratio was significant in both groups (P < 0.05); however, the main effects of stride length, stance time, and gait asymmetry ratio were nonsignificant (P > 0.05). For barefoot versus AFO, the main effects of stride length (P < 0.05) and swing time (P < 0.01) ratios were significant, whereas those of stance time and gait asymmetry ratio were nonsignificant (P > 0.05).
CONCLUSIONS: Post-stroke patients with lower Brunnstrom stages benefitted more from AFO, particularly in gait asymmetry.
FIELD: medicine. SUBSTANCE: main ingredients of balsam are biologically active substances and gel-forming composition. As biologically active substances used are bornyl or isobornylacetate, α-pinene, camphor, salicylic acid or sodium salicylate, and benzyl alcohol and copper sulfate. Gel-forming base contains distilled water, glycerin, ethanol, or isopropanol and blockcopolymer of oxide of ethylene and propylene. EFFECT: higher ANTIMICROBIAL, antiinflammatory and analgetic efficiency. 1 tbl
INTRODUCTION: Deciding whether to perform coronary artery bypass grafting (CABG) alone or in combination with mitral valve repair is a common dilemma encountered by surgeons when treating patients with ischemic mitral regurgitation, a common condition related to coronary artery disease. Although ischemic mitral regurgitation after CABG has been linked to unfavorable results, the benefits of including mitral valve repair are still unknown. This discrepancy led us to undertake a systematic review and meta-analysis to determine whether combining CABG with mitral valve surgery leads to better clinical results than CABG alone.
EVIDENCE ACQUISITION: Studies comparing the results of CABG versus CABG with mitral valve replacement were searched in the databases of PubMed and Google Scholar. There were six randomized clinical trials included in this study.
EVIDENCE SYNTHESIS: We analyzed 852 patients' data. There were no significant variations between patients who acquired CABG alone or CABG+(MVR) in terms of their risk of death at one year, stroke, atrial fibrillation, or hospitalization for heart failure. For recurrent/residual mitral regurgitation; it revealed an RR=5.42, 95% CI, 0.77 to 37.98, and a P value of =0.065. According to the analysis of study heterogeneity, no apparent heterogeneity was identified in the outcomes of death after one year, stroke, atrial fibrillation, or hospitalization for heart failure. However, the outcome of recurrent or residual mitral regurgitation showed significant variation (I2=66%).
CONCLUSIONS: Patients who underwent CABG alone versus CABG plus MVR did not differ significantly from one another. However, the comparison of CABG alone with CABG plus MVR underlines the need for customized treatment plans based on the unique characteristics of each patient.
Disclosed are a hyaluronic acid facial mask, a preparation method therefor and a use method therefor. The facial mask comprises a substrate layer, a hyaluronic acid layer and a protective paper layer sequentially arranged. The hyaluronic acid layer is made of hyaluronic acid nanofibers. The hyaluronic acid nanofibers are formed by spinning a hyaluronic acid composite using an electrostatic spinning method. The hyaluronic acid composite comprises a dispersed phase and a solvent phase. The dispersed phase comprises, in terms of mass percentage content, 70-95% of hyaluronic acid. The solvent phase comprises water. The preparation method comprises: spinning the hyaluronic acid composite on the substrate layer using an electrostatic spinning method to form a hyaluronic acid layer, and then attaching the protective paper layer on the hyaluronic acid layer. During use, water is applied to a part to be used, and then the hyaluronic acid layer of a facial mask from which the protective paper layer has been removed is directly attached to the part to be used. The facial mask is easy to prepare, reduces the usage of hyaluronic acid, and improves the utilization rate of hyaluronic acid.
Postoperative seroma formations are one of the most common and serious complications after breast surgery, above all after mastectomy. Especially in patients who have opted for breast reconstruction using implants, seromas lead to infections and wound dehiscence which can result in implant and finally breast loss. To date, the cause of seroma development has not yet been clarified. First data of a pilot study of our research group identified an association with immunological-inflammatory processes as a possible cause for seroma development (Seroma after Simple Mastectomy in Breast Cancer-The Role of CD4+ T Helper Cells and the Evidence as a Possible Specific Immune Process; Pochert et al. 2022).

The main objective of the SerMa (Seroma of the Mammary gland) study presented here is to identify patient groups who have an increased risk of developing seromas based on immunological/inflammatory processes. Based on the findings clinical consequences should be developed in the future, such as more precise risk-adapted patient education and individualized advising regarding the selection of the reconstruction procedure, with the goal of minimizing complication rates. In addition, analyses of the tumor and the microenvironment will be performed to differentiate possible carcinoma-specific immunological processes.
An exemplary system, method, and computer-accessible medium for recommending a model(s), can include, for example, receiving a plurality of test models including the model(s), determining if each of the test models has at least one verifier associated therewith, and recommending the model(s) based on the determination. An indication of a stake associated with each of the test models can be received. The stake can be a financial stake or a reputation stake. The financial stake can be a cryptocurrency. At least one of the test models can be analyzed using a machine learning procedure, which can be a convolutional neural network or a recurrent neural network. At least one of the test models can be analyzed using an empirical Bayes procedure. A particular model can be removed if the particular model(s) does not have a verifier(s) associated therewith.
Beginning on day 1, patients receive losartan potassium PO QD. Beginning day 14, patients also undergo hypofractionated radiation therapy over 15 fractions 5 days a week for up to 3 weeks. Patients continue to receive losartan potassium PO QD during radiation therapy and for 28 days after completion of radiation therapy. Patients may begin additional anti-cancer therapy per investigator discretion after the last dose of HRT. Losartan can be given concurrently with additional therapy and Losartan dosing can continue until 28 days after last dose of HRT, regardless of when additional therapy is started.
After completion of procedure and before extubation, bilateral ultrasound guided subcoastal transversus abdominis plane (TAP) block will be performed by the primary anaesthetist. After taking aseptic measures, with patient in supine position a high frequency (6-13 MHz) linear ultrasound probe will be placed obliquely just inferior to the costal margin over the anterior abdominal wall. With the help of a 21G or 22G, 100 mm needle, 20 ml of 0.375% Ropivacaine will be injected between rectus sheath and fascia of transversus abdominis muscle, bilaterally.
Ulcers of the lower extremities, particularly in patients older than 65 years, are common among the population. Studies estimate the prevalence of current chronic leg ulcers at approximately 1%. The most common cause (approximately 80%) is thought to be chronic venous insufficiency disease. Recurrent cellulitis is an additional common cause. The ulcers cause a significant morbidity and negative impact on the patients' quality of life. The care of chronic vascular ulcers places a significant burden on the patient and the health care system. Additionally, these nonhealing ulcers place the patient at much higher risk for lower extremity amputation.

Natural Matrix Bio polymer Membrane (NMBM) is a novel topical cosmetic cream containing a mix of natural waxes, sugars and lipids. The aim of this study is to test whether of Natural Matrix Bio polymer Membrane (NMBM) is effective as an adjunctive therapy to the treatment of venous stasis and post-erysipelas leg ulcers.
Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung interstitium. The early inflammatory cascade coupled with recurring tissue injury orchestrates a set of events marked by perturbed matrix hemostasis, deposition of matrix proteins, and remodeling in lung tissue. Numerous investigations have corroborated a direct correlation between the NLR family pyrin domain-containing 3 (NLRP3) activation and the development of pulmonary fibrosis. Dysregulated activation of NLRP3 within the pulmonary microenvironment exacerbates inflammation and may incite fibrogenic responses. Nevertheless, the precise mechanisms through which the NLRP3 inflammasome elicits pro-fibrogenic responses remain inadequately defined. Contemporary findings suggest that the pro-fibrotic consequences stemming from NLRP3 signaling primarily hinge on the action of interleukin-1β (IL-1β). IL-1β instigates IL-1 receptor signaling, potentiating the activity of transforming growth factor-beta (TGF-β). This signaling cascade, in turn, exerts influence over various transcription factors, including SNAIL, TWIST, and zinc finger E-box-binding homeobox 1 (ZEB 1/2), which collectively foster myofibroblast activation and consequent lung fibrosis. Here, we have connected the dots to illustrate how the NLRP3 inflammasome orchestrates a multitude of signaling events, including the activation of transcription factors that facilitate myofibroblast activation and subsequent lung remodeling. In addition, we have highlighted the prominent role played by various cells in the formation of myofibroblasts, the primary culprit in lung fibrosis. We also provided a concise overview of various compounds that hold the potential to impede NLRP3 inflammasome signaling, thus offering a promising avenue for the treatment of pulmonary fibrosis.
The present invention discloses health care salt. 6 to 4% of tangerine peel extract and tabasheer liquid are uniformly penetrated into 94 to 96% of high quality table salt. The health care salt relates to the technical field of health care flavouring salt. The health care salt is suitable for being used as the health care flavouring salt by people. The health care salt can supply various active organic substances, and the health care salt has a health care function to patients with iron deficiency and potassium deficiency. The health care salt can reduce gastric acid, and the health care salt has a positive effect for preventing enterospasm; meanwhile, the health care salt has the favorable health care functions of lowing cholesterol, preventing blood vessel hardening, enhancing an appetite and enhancing digestion functions.
Including 150 patients who will undergo withholding gonadotropin administration for at least 24 hours before triggering ovulation with hCG. GnRH agonist will be continued daily till the day of triggering. E2 will be measured daily until the concentration falls to ≤ 3000 pg/ml, then 5000 IU of hCG will be given.