anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The use of ceftriaxone, a highly protein-bound drug, in the setting of hypoalbuminemia may result in suboptimal drug exposure. Patients with obesity also exhibit higher absolute drug clearance. We aimed to evaluate the impact of hypoalbuminemia on clinical success among hospitalized adults with obesity who were treated with ceftriaxone. This retrospective review included adult inpatients with weight >100 kg or body mass index >40 kg/m2 who received ceftriaxone 2 g intravenously every 12 hours for at least 72 hours. The primary outcome was clinical success, a composite of clinical cure and microbiologic cure. Secondary outcomes included clinical cure, microbiologic cure, length of stay, ICU length of stay, mortality, 30-day readmission, and adverse events. In all, 137 patients were included, 34 of whom had a serum albumin of ≤2.5 g/dL. In a propensity-score-weighted analysis, clinical success was significantly more common among those without hypoalbuminemia (91.2%) as compared to those with hypoalbuminemia (77.8%) (P = 0.038). Death within 30 days (13.7% vs 0%, P < 0.001) and 30-day readmission (31.6% vs 12.0%, P = 0.008) were more common in the hypoalbuminemia group. In a univariate analysis, serum albumin and indication for ceftriaxone use were found to be predictors of clinical success. Hypoalbuminemia was associated with a lower rate of clinical success among patients with obesity who were treated with ceftriaxone 2 g every 12 hours.
FIELD: chemistry. ^ SUBSTANCE: invention relates to a complex of active substances consisting of a salt of o-acetylsalicylic acid with basic amino acid and glycine, with average particle size of not less than 100 mcm. Said complex is obtained using a method according to which o-acetylsalicylic acid and a basic amino acid quickly bond in water or in a water-miscible organic solvent at temperature lower than or equal to 40C. The homogeneous mixture is then cooled to 5-10C. Cooled acetone and a cooled suspension of glycine in a water-alcohol mixture are then simultaneously added, stirred for at least 1 hour at temperature not higher than 5C, followed by extraction of the crystallisation product. ^ EFFECT: high stability and possibility of use in medicine. ^ 10 cl, 1 tbl, 3 dwg, 1 ex
<P>PROBLEM TO BE SOLVED: To provide a supplement sheet which can simply give one or more nutrients through foods.  <P>SOLUTION: This supplement sheet 11 comprises a substrate 13 having a rectangular sheet shape and a vitamin C-containing nutrient holding layer 15 formed on the whole surface of one side of the substrate sheet 13. The substrate sheet 13 comprises a PET film and the nutrient-holding layer 15 is formed by coating the substrate sheet 13 with vitamin C together with starch as a binder. When used, the supplement sheet 11 is disposed on a food in a lunch box or the like. Thus, the vitamin C in the nutrient-holding layer 15 is dissolved into the food, and can easily be taken by eating the food.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Children from low income families generally suffer from hard conditions,such as poor living conditions, inadequate nutrition, and delay in accessing health care services. Such problems may made children suffer from developmental problems and malnutrition and to have a lower level of intelligence and difficulties in language comprehension, which may not only have profound impacts on children's physical well-being, but on their psychological well-being as well. Musical training is considered to have potential for promoting psychological well-being among children mostly because music is found to be important to a child's early psychological development. A growing number of educators and researchers suggest that, of all the stages of life, infancy may be the time when music has the most important impact on an individual. Babies hear language long before they are able to comprehend it. The quality and the quantity of what is unconsciously absorbed in infancy relates directly to later development. Musical training has been used for various purposes such as improving language development, self-expression, memory skills, concentration, social interaction, fine motor skills, listening, problem-solving, teamwork, goal setting, and coordination. More importantly, when a child learns to sing and play music, other areas of development - creativity, family bonding, self-esteem, confidence, emotional development - are also positively impacted.

Nevertheless, although musical training is popular and is considered to be a beneficial intervention in the promotion of psychological well-being, longitudinal studies that examine the efficacy of music-making in children from low-income families are limited. Importantly, there is to date no study that examines the effects of musical training on enhancing the psychological well-being among these children. There is an imperative need for rigorous empirical scrutiny of the effectiveness of musical training in promoting the psychological well-being of children from low-income families. Therefore, the aim of this study is to examine the effectiveness of musical training in promoting happiness and quality of life of preschool children from low-income families.
The invention discloses an injectable double-crosslinked hyaluronic acid aquagel and a preparation method thereof. The preparation method comprises the following steps: synthesizing formylated hyaluronic acid and amino/methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain, uniformly mixing the formylated hyaluronic acid and amino/methylacryloyl bifunctional hyaluronic acid containing disulfide bond in the side chain with a water-soluble photoinitiator, and carrying out photochemical polymerization to obtain the injectable double-crosslinked hyaluronic acid aquagel. The method has the advantages of accessible raw materials, mild reaction conditions, short reaction time, simple technique and the like. The prepared aquagel is formed by a Schiff base crosslinking mechanism and a photocrosslinking mechanism, and the two crosslinking networks are connected together. The crosslinking network chain of the aquagel contains the disulfide bond and Schiff base, and thus, the aquagel has dual sensitivities for reduction and pH. The hyaluronic acid aquagel has flexible and adjustable mechanical properties, microstructure, degradation property, swelling capacity and the like, is injectable, and has application prospects in the aspects of cell transfer, tissue engineering, three-dimensional cell culture and the like.
PURPOSE:A dental composition providing a cured dental molded article having improved hardness, mechanical strength, appearance, etc., obtained by polymerizing a carboxylic acid monomer with a vinyl monomer in the presence of an inorganic compound to give an organic composite filler, blending it with a vinyl compound. CONSTITUTION:A carboxylic acid monomer (e.g., acrylic acid, methacrylic acid, etc.) shown by the formula I (R1-R3 are H, 1-15C alkyl, etc.; X, Y, and Z are H, NH4, etc.) or formula II (R4 and R5 are H, 1-15C alkyl, etc.) is polymerized with a radically polymerizable vinyl monomer (preferably methyl methacrylate) in the presence of an inorganic compound (e.g., barium sulfate, silicon dioxide etc.), to give an organic composite filler. The filler has firm integrity of the inorganic compound and the organic polymer, and improved interfacial affinity. It is blended with a vinyl compound (e.g., ethylene glycol dimethacrylate, etc.), to give an improved dental composition which has not been found before.
This is a K01 award application for Dr. Heather Hayes, a neurologic rehabilitation therapist and a young investigator pursuing rehabilitation health services research to optimize post-acute rehabilitation care for patients after stroke. A K01 award will provide Dr. Hayes with the means to acquire critical skills in three key career development areas: 1) health services and policy research, 2) comparative effectiveness and outcomes research, and 3) cost-effective analyses. By acquiring these skills, Dr. Hayes will fulfill the career goal of becoming an independent rehabilitation scientist in health services research. To pursue this goal, Dr. Hayes has assembled an exceptional mentoring team complemented by a strong statistical advisor and proposes strong research aims that provide experiential learning in support of the career development objectives.

Stroke is a leading cause of long-term disability in the United States. A large portion of the cost of stroke care is rehabilitation. Providing optimal rehabilitation services aids in mitigating long-term disability for people after stroke. There are a lack of clinical guidelines and poor understanding of long-term outcomes after discharge from acute care to an inpatient rehabilitation facility (IRF) or skilled nursing facility (SNF) for individuals poststroke. The current healthcare climate requires faster decision making and early discharge, and the results may be inappropriate discharge to an IRF or SNF, and thus not providing the patient with optimal outcomes. By completing the following specific aims, the applicant aims to inform clinicians in the acute care setting about discharge placement and which rehabilitation service will lead to optimal individual and cost-effective outcomes after stroke. Specific Aim 1 will determine client (e.g., stroke severity, co-morbidities, and sociodemographic) and non-client (e.g., bed availability and insurance) variables identified at the end of the acute hospital stay to determine which of these variables are associated with discharge to an IRF or SNF. Specific Aim 2 will follow the clients to determine which of these client and non-client variables are associated with functional change- based on the Activity Measure for Post-Acute Care (AM-PAC) Inpatient "6-Clicks" Basic Mobility, Daily Activity, and Applied Cognitive tools at short-term (after discharge from IRF or SNF) and long-term (6-months poststroke). Specific Aim 3 will identify cost-effective strategies of placement into an IRF, to a SNF, and a tailored approach to IRF vs. SNF placement, based on client characteristics. Markov modeling will be used to predict related costs and quality-adjusted life years using the Health-Related Quality of Life in Stroke Patients.

Understanding the outcomes within these similar post-acute care settings (IRF/SNF) for stroke is important in a rapidly evolving healthcare climate. This study is significant because it will provide data about what initial client and non-client variables predict long-term outcomes after discharge to an IRF or SNF and identify cost-effective strategies based on these variables.
Patients receive 20mg oral R-(-)-gossypol acetic acid once daily on days 1-21. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
The control group participates only in questionnaire data collection at baseline, 4 months, and 6 months as well as daily weighing. Control group participants will be offered 3 web-based seminars (webinars) highlighting the effective lifestyle approaches demonstrated in the study and intervention group health education materials. The webinars and materials will be provided after the 6-month data collection which concludes the study.
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, leading to low blood oxygen levels and respiratory failure. Common causes include pneumonia, lung trauma, and sepsis, a condition that can lead to widespread inflammation and blood clotting in response to an infection. Recent studies have shown that insulin, which is regularly used to control blood sugar levels, may prevent or lessen the risk of lung tissue inflammation and/or lung injury related to sepsis. Research has shown that critically ill ICU patients often benefit from receiving insulin to target 80-110 mg/dl , but it is not known if insulin to target these levels can prevent the onset of ALI/ARDS. Therapies to prevent ALI/ARDS should occur early, preferably even prior to ICU admission, because at least 38% of people with ALI/ARDS are diagnosed with the condition once they reach the ICU. The purpose of this study is to determine whether insulin to target 80-110 mg/dl administered to critically ill patients in the emergency department (ED) is more beneficial at preventing ALI/ARDS than insulin to target 150-180 mg/dl after ICU admission.

This study will enroll people who are hospitalized with high blood sugar levels and severe sepsis. Participants will be randomly assigned to receive IIT within 6-12 hours of ED presentation to target 80-110 mg/dl or target 150-180 mg/dl for 48 hours after admission to the ICU followed by usual care. Prior to ICU admission and 1, 3, and 7 days after ICU admission, blood will be collected and analyzed for markers of inflammation and lung injury. Blood samples will be stored for future research studies. While participants are in the hospital, their medical records will be reviewed to gather information on medical and family history, demographics, vital signs, laboratory test results, x-ray findings, and lung function. Study researchers will also monitor participants for the development of severe lung failure or other organ failures.
The entire intervention will last 16 weeks, including 1-hour supervised training sessions twice a week during weeks 1 to 8 (training; 16 hours), and 1-hour supervised weekly follow-up sessions during weeks 9 to 16 (followup; 8 hours). The sessions will be supervised by an experienced qigong master.
INTRODUCTION: It is important for health care professionals to address women's pain and anxiety during pelvic examinations. This study aimed to evaluate the impact of virtual reality (VR) on pain and anxiety management during pelvic examinations.
METHODS: The study was a randomized controlled clinical trial reported in according to the Consolidated Standards of Reporting Trials 2010 Guidelines. The research was conducted with 128 women (64 intervention, 64 control) who received care at a tertiary hospital outpatient clinic between November 2021 and February 2022. The intervention group received VR application via virtual glasses during pelvic examination, while the control group received routine care. Anxiety was measured using the State-Trait Anxiety Inventory before and after the pelvic examination, and the Visual Analog Scale was used to assess pain after the pelvic examination. The study was registered at ClinicalTrials.gov (NCT05545488).
RESULTS: The mean anxiety scores of the women in the intervention and control groups were similar pretest (59.00 and 57.77). The mean anxiety score decreased after the pelvic examination to 36.53 in the intervention group and 47.55 in the control group. Results indicated a significant main effect for group assignment (F9.56; η2 = .071; P = .002), a significant main effect for time (F384.14; η2 = .753; P < .001), and a significant interaction between group and time (F53.95; η2 = .300; P < .001). Pain scores after the pelvic examination were lower in the intervention group (4.25) than in the control group (6.41; P < .001).
CONCLUSION: VR was effective in the management of pain and anxiety during pelvic examination. Future studies should compare the effectiveness of VR with other methods in reducing pain and anxiety during a pelvic examination.
Undergo surgery, followed by chemotherapy (cis Platinum/Carboplatin, Pemetrexed Disodium). Patients receive chemotherapy comprising cisplatin 75mg/m2 or Carboplatin AUC=5mg/ml/min, and pemetrexed 500mg/m2 in day 1. Treatment continues every 3 weeks for 4 courses.
The present invention relates to an externally-used Chinese herbal medicine preparation for curing scalds and burns and a preparation method thereof. The externally-used Chinese herbal medicine preparation for curing scalds and burns comprises buttercup, alcohol and water through the processes of water decoction of the buttercup, normal pressure boiling, filtration to eliminate dregs, mixing with the alcohol and sealing up. The externally-used Chinese herbal medicine preparation for curing scalds and burns has the advantages of simple components and preparation method, convenient use and no need of enswathement. The externally-used Chinese herbal medicine preparation for curing scalds and burns can effectively control the infection of wound surfaces, eliminate fire toxins in vivo and quickly reduce the seepage of the wound surfaces. Through clinical tests, the scald curing buttercup liquid can cure I degree and II degree burns and scalds. The cure rate of the externally-used Chinese herbal medicine preparation for curing scalds and burns can be up to 100%. The wound surfaces are smooth and have no scars and only have pigmentation. The scald curing buttercup liquid is an ideal externally used Chinese herbal medicine preparation for curing scalds and burns.
Patients are randomized to receive for 12 months Linagliptin 2.5mg + metformin 1700mg every 24 hours. The start of the dose in this group will be gradual so that at the month of treatment the patient can be with the full doses. Together with this, patients will receive a lifestyle modification program seeking to reduce 5-7% of body weigh and increase physical activity to 90-150min/week.
Study 1 addresses the concerns of pneumonia risks in quadriplegics with compromised respiratory pump mechanics. In cases of spinal cord injury or high-level motor neuron disease, complications with respiratory function are a common concern. Lack of innervation to the intercostal and abdominal muscles can cause a decline in respiratory capacity as well as overall lung function, with associated increased risk of mortality. Shallow tidal breathing and impaired or absent cough results in morbidity and mortality from pneumonia. Several studies have found failure of the respiratory system, including pneumonia, to be a leading cause of mortality among spinal cord injury patients. In order to maintain pulmonary health, many people with quadriplegia and other high-level motor neuron diseases undergo routine respiratory therapy to help stretch the muscles around the lungs, exercise the diaphragm, and loosen mucus build-up. Incentive spirometry is one commonly used component of respiratory therapy designed to mimic natural sighing or yawning by encouraging the patient to take long, slow, deep breaths. This is done with an incentive spirometer device, which provides patients with visual or other positive feedback with a piston or a ball that moves inside a gauge. Respiratory therapy techniques are also used to help maintain pulmonary health in individuals with a number of chronic or temporary respiratory diseases and conditions such as asthma, chronic obstructive pulmonary disease, and emphysema. These techniques often become strenuous and mundane for users with limited mobility, and thus patient compliance rates are low. Gaming controlled by forceful respiratory maneuvers will be studied to ascertain if respiratory mechanics can be improved in this group.

Testing Plan: Study participants will be randomized into 2 groups through drawing of sealed envelopes. Group 1 (control group) will be given the standard Jamboxx musical device (see appendix a for device details), while Group 2 (treatment group) will be given the Jamboxx respiratory therapy device, which combines musical gameplay with incentive spirometry exercises. Participants from both groups will have two 20 minute training sessions with the device: one initial training visit and one follow up visit. Training sessions will take place either in the home, or at Albany Medical Center. During the initial visit a simple spirometry test (FEV1, FVC and PEF) and maximum inspiratory and expiratory pressures (MIP and MEP) will be performed. These functions will be measured again at 3, 6, 9 \& 12 months by a respiratory therapist (RT). The Dyspnea-12 (D-12) questionnaire will be conducted at by the RT at months 0, 3, 6, 9, and 12. Self-Reported Patient Dyspnea and the Multidimensional Dyspnea Profile (MDP) will be reported electronically by study participants on a weekly basis. Medical records will be evaluated for relevant health history, medication use, and hospitalizations including dates. Access to medical records will be obtained by a signed medical release form.
<P>PROBLEM TO BE SOLVED: To provide a method for inactivating viruses in a virus-containing blood product.  <P>SOLUTION: A solvent/cleanser treatment has been adopted to inactivate enveloped viruses in a blood product. It has been considered that the concentrations of 1.0 % of a solvent and 0.3 % of tri-n-butyl phosphate are necessary for firmly removing the activity of the viruses, but the inventor of the present invention has show the effect of fractionation and nanofiltration on the preparation of immune gamma globulin. Such treatment needs the remarkably reduced concentrations of the solvent and the cleanser. Such the reduced amounts of the solvent and the cleanser are connected to possibility to a relatively high yield and a reduced treatment cost, and to a relatively high efficiency in their removal after the inactivation.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
A method for determining a coloring product recommendation, in particular a hair coloring product recommendation. A first image representing an object colored with a coloring product is obtained. The color of a rendered object is identified on an image by determining a global color value taking into account different elements within the image. The desired color is then obtained. A recommendation for a coloring product to achieve a desired color is determined. The recommended coloring products correspond to products in which: the color difference between the desired color and the identified color is maintained below a predetermined threshold.
Tuberculosis is a global disease and presents with an array of neurological manifestations. Presentation varies from meningitis, radiculo-myelitis, tuberculoma, brain abscess and other combinations. The association of Guillain-Barre' syndrome (GBS) with tuberculosis has been reported in a few reports. Neurological tuberculosis association with GBS is very rare. We here report an early adolescent patient with tubercular meningitis and tuberculoma who presented with acute areflexic quadriparesis and was subsequently diagnosed as an acute motor sensory axonal neuropathy variant of GBS. The diagnosis was confirmed with clinical examination, nerve conduction studies, positive anti-ganglioside antibody and clinical response to intravenous immunoglobulin. We present a case of an association between tubercular meningitis clinically presenting as encephalopathy and acute flaccid weakness due to GBS.
The invention discloses a function and an application of an IRF1 (interferon regulatory factor 1) gene in treatment of fatty liver and diabetes. An IRF1 gene overexpressed mouse and a WT (wild type) C57 mouse are used as experimental subjects, the function of the RGS10 gene is studied by the aid of an HFD (high fat diet) induced obesity mouse model, and the result indicates that compared with the WT C57 mouse, the IRF1 gene overexpressed mouse shows severe obesity and has the fasting blood glucose level higher than that of the WT mouse in a control group and the liver function obviously poorer than that of the WT mouse. An intraperitoneal injection glucose tolerance experiment finds that the tolerance capacity of the IRF1 gene overexpressed mouse is obviously weakened. The mouse liver weight, liver/weight ratio and lipid component pathological staining results indicate that fatty liver lesion of the IRF1-TG mouse in an HFD group is obviously aggravated and lipid accumulation is significantly increased. Therefore, the IRF1 can be used as a drug target for screening and treating the fatty liver and/or type-II diabetes. An IRF1 inhibitor can be used for preparing drugs for treating the fatty liver and/or type-II diabetes.
Participants will receive Sudapyridine (WX-081) tablets orally at a specified dose once daily for 10 days (in Study A and Study B) or once under fasting and fed conditions (in Study C). Pharmacokinetic sampling and safety assessments will be conducted.