anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a drug abstinence traditional Chinese medicine, which is made of the following Chinese herbal raw materials: Polygala japonica, angelica, Radix Polygalae, Mucuna macrocarpa, Rhizoma Homalomenae, Schizophragma integrifolium, ginseng, aspongopus, pearl, Changium smyrnioides, lumbricus, tangerine peel, eucommia, Common Carpesium Fruit, medlar, radix bupleuri, Cordyceps, jujube kernels, fructus amomi, rice husks, and licorice. The drug abstinence traditional Chinese medicine provided by the invention can expel the toxicity in various viscuses in the human body, tonify qi, promote essence and blood flow, regulating blood, help digestion, increase diet, and has the efficacy of strengthening kidney and tonifying liver, strengthening heart and improving brain. A good curative effect can be achieved after patients taking the traditional Chinese medicine, and recurrence can be hard to drug addicts after cure. The drug abstinence traditional Chinese medicine provided by the invention has a rigorous and scientific formula, all drugs reach the best compatibility, and the traditional Chinese medicine is convenient for patients to take and has a quick effect. After taking the medicine for a course of treatment, patients can abstain from drug addiction. Thus, the traditional Chinese medicine is an ideal medicine for drug abstinence.
The present invention relates to the field of vitamin D insufficiency and deficiency, viz. too low blood levels of 25(OH)D, and to their prevention and treatment. It provides a vitamin D supplement which comprises (i) a combination of 25(OH)D3 and/or 25(OH)D2 and vitamin D2; or (ii) a combination of 25(OH)D3 and/or 25(OH)D2 and vitamin D3; or (iii) a combination of 25(OH)D3 and/or 25(OH)D2 and a combination of vitamin D2 and vitamin D3, for use in the treatment of and/or prophylaxis of vitamin D insufficiency or deficiency in obese persons, overweight persons having the tendency to get obese or persons having a history of malabsorption of vitamin D or persons with a genetic disposition to develop obesity. Also provided are corresponding compositions and dosage regimens comprising such vitamin D supplements as well as kits comprising such compositions. Furthermore, corresponding dosage regimens for daily administration and corresponding product package inserts are also provided. The invention also relates to corresponding methods of treatment.
Patients randomised to the control group will, in addition to their routine compression bandaging, be given muscle stimulators for home use and instructed to apply 3x 30 minute sessions of comfortable electrical stimulation daily for 12 weeks. The stimulators given to the control group will be set to provide minimal stimulation resulting in no visible muscular contraction.
PURPOSE:To inactive viruses and obtain immunoglobulin having good solubility in water and stability, by heating immunoglobulin contaminated by viruses in a dry state in the presence of a specific stabilizer. CONSTITUTION:Immunoglobulin contaminated by viruses in a dry state is heated in the presence of at least one stabilizer selected from sugar alcohols and disaccharides until the viruses are inactivated to afford the aimed virus- inactivated immunoglobulin. Immunoglobulin derived from, e.g. human, horse and mouse, may be cited as the immunoglobulin and may be either one of polyclonal antibody and monoclonal antibody, preferably IgG, IgA or IgM. In the dry state, the moisture is normally <=3% and heating is carried out under condition of 30-100 deg.C for 10min-20hr. The stabilizer is used as 1-5wt%/ vol% concentration for a 0.01-2wt%/vol% solution of the monoclonal antibody or a 2-8wt%/vol% solution of the polyclonal antibody.
Evidence suggests that deficits in affect regulation play an important role in the development and maintenance of binge eating disorder (BED). Thus, we aim to clarify whether BED symptoms can be reduced with the help of a training of general affect regulation skills. For this purpose, we randomly allocated N = 99 individuals meeting criteria for BED either to an affect regulation training (ART) or to a wait list control condition (WLC). Primary outcome is the reduction of binges during the treatment-vs.-waiting period as assessed with the Eating Disorder Examination (EDE) interview. Secondary outcomes include BED symptom severity at follow-up and change in emotion regulation skills. To clarify whether potential differences between groups regarding change in binge eating result from a greater increase of affect regulation skills in ART, we will test whether potential group differences regarding binges will be mediated by differences between groups regarding change in affect regulation skills.

Change of randomization procedure: Over the course of the study, serious difficulties occurred with regard to recruiting participants as quickly as necessary to avoid drop-outs due to participants' unwillingness to wait until eight individuals were recruited for randomization. To solve the problem, we switched from the original block randomization to a procedure in which the next patient eligible for the study was allocated to the treatment condition until the minimum group size of four was reached.
The invention provides an ORF sequence of ETV2 and a preparation method of endothelial cells, belonging to the technical field of endothelial cell development. The ORF sequence of the ETV2 is shown as SEQ ID NO.1, so that the ETV2 protein can be expressed efficiently, more ETV2 proteins can be obtained through translation, the expression efficiency is higher, and the transformation efficiency can be remarkably improved through differentiating stem cells into endothelial cells. The preparation method of endothelial cells provided by the invention has the advantages of high preparation efficiency and low clinical application risk. Therefore, the problem that the stem cells cannot be safely and efficiently differentiated into endothelial cells in the prior art is solved. The invention can efficiently and rapidly realize mass preparation of endothelial cells, and meets the requirements of reprogramming cell fate and endothelial differentiation. The preparation method provided by the invention provides a stable cell source for direct injection of endothelial cells to an ischemic site, promotion of angiogenesis and improvement of tissue perfusion.
BACKGROUND: Accurate prediction of peritoneal recurrence for gastric cancer (GC) is crucial in clinic. The collagen alterations in tumor microenvironment affect the migration and treatment response of cancer cells. Herein, we proposed multitask machine learning-based tumor-associated collagen signatures (TACS), which are composed of quantitative collagen features derived from multiphoton imaging, to simultaneously predict peritoneal recurrence (TACSPR) and disease-free survival (TACSDFS).
METHODS: Among 713 consecutive patients, with 275 in training cohort, 222 patients in internal validation cohort, and 216 patients in external validation cohort, we developed and validated a multitask machine learning model for simultaneously predicting peritoneal recurrence (TACSPR) and disease-free survival (TACSDFS). The accuracy of the model for prediction of peritoneal recurrence and prognosis as well as its association with adjuvant chemotherapy were evaluated.
RESULTS: The TACSPR and TACSDFS were independently associated with peritoneal recurrence and disease-free survival in three cohorts, respectively (all P < 0.001). The TACSPR demonstrated a favorable performance for peritoneal recurrence in all three cohorts. In addition, the TACSDFS also showed a satisfactory accuracy for disease-free survival among included patients. For stage II and III diseases, adjuvant chemotherapy improved the survival of patients with low TACSPR and low TACSDFS, or high TACSPR and low TACSDFS, or low TACSPR and high TACSDFS, but had no impact on patients with high TACSPR and high TACSDFS.
CONCLUSIONS: The multitask machine learning model allows accurate prediction of peritoneal recurrence and survival for GC and could distinguish patients who might benefit from adjuvant chemotherapy.
Provide CRC education, SN education, handouts and text message/social media posts example library. Monthly Telephone Support Provide any additional support to index participants for peer FIT testing, assist in completion of peer outreach tracker. Biweekly Text Messages. Follow-up Assessment (month 8 after intervention) Complete follow-up form and assist in completion of peer outreach tracker Provide reminders to encourage participants to encourage peers to get FIT tested.
The present invention provides methods for configuring a printer template (40) and a ticket printer (10) having a configurable template. Template attributes (36) are received at the printer and stored in printer memory (12). A processor (18) at the printer creates a template (40) from the template attributes (36). Print data (16) is provided to the printer memory. The print data is merged into the template to create a composite image (50). The composite image can then be printed on a substrate. The substrate may comprise a receipt, a lottery ticket, a coupon, a bus ticket, an airplane ticket, a train ticket, a gaming voucher, a slot machine voucher, or the like.
Dementia and incontinence are both prevalent in older age; yet, neither are an inevitable or normal part of ageing. It has been recognised that there is a skills and knowledge gap in professionals assessing and managing incontinence for people living with dementia. All too often, assumptions are made that incontinence is a symptom of dementia and that nothing can be done if a person living with dementia experiences episodes of incontinence. While dementia may impact on a person's ability to remain continent, it may not be the sole cause, and there may be treatments and strategies that can reduce the incidence in those affected. Therefore, a person-centred continence assessment should be undertaken to promote continence and reduce the impact of incontinence for people living with dementia and those who care for them. This paper will highlight some of the issues that are important for health and social care professionals to explore and identify, assess and manage incontinence to improve outcomes for families affected by dementia.
A significant subset of patients are found to have "unexplained chronic cough", which is a diagnosis of exclusion. For these patients, the etiology of the cough is often not isolated. However, the cause is thought to be related to hypersensitivity and inflammation of both the nerves involved in cough sensation and/or mucosa of the larynx. A similar theory described by Driessen et al. hypothesizes that neuroinflammation related to glial cells in central and peripheral neural pathways may contribute to chronic cough in a similar way to how chronic pain is mediated by this pathway. Glial cells in the central and peripheral nervous system may be an important target for steroid hormones and their metabolites, which may have impact on inflammation and excitatory action.

Superior laryngeal nerve injections have been well studied in literature and were recently studied here at the Medical University of South Carolina in a prospective placebo-controlled trial for use in neurogenic cough. This study showed that there was a significant improvement in cough compared to placebo. This study was completed using randomization of 17 patients into the control and steroid/lidocaine injection groups. In the treatment group, 80% of patients reported improvement in symptoms, while in the control group only 14% of patients reported improvement. The Leicester Cough Questionnaire (LCQ) and visual analog scoring were used to compare cough data from pre and post injection.

The hypothesis revolves around the idea that SLN blocks may actually work systemically, so the site of injection may not be the key in cough improvement. This combined with the theory on glial cell involvement and systemic steroid use to inhibit the neuroinflammatory pathway leads us to believe that intramuscular steroid injections could improve chronic cough. Therefore, this study focuses on the use of systemic intramuscular steroids in patients with chronic cough and we hypothesize that patients will have improvement in cough severity. By opening another treatment option that could be utilized by general (non-fellowship trained) otolaryngologists, access to care and treatment may be improved for patients with chronic cough.
The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a method for preparing an effective activity part of pueraria. The invention in particular adopts the method of diluted alcohol extraction-ethanol reclaiming from the diluted alcohol till alcohol-free taste-D101 macroporous resin-ethanol elution, condensation and drying; and the effective activity part-pueraria flavone is extracted from traditional Chinese medicine the pueraria. The method adopts 20 to 40 percent ethanol to extract medicine material, can effectively extract the pueraria flavone, and reduce the extraction of impurity, so that the pueraria flavone can be better richened on the macroporous resin. The method improves the purity of the pueraria flavone in the extract, and considers both the transfer rate and the yield of the extract simultaneously so as to obtain the extract of the effective activity part of the pueraria with stable transfer rate and yield and higher purity. The content of the pueraria flavone in the extract is more than 70 percent; and the content of puerarin of the pueraria flavone in the extract is more than 30 percent. In a preparation prepared by the method, the effective composition has high and stable content and remarkable treatment effect. The effective composition is added with an auxiliary material or an auxiliary composition accepted in pharmacy to prepare a medicine preparation.
Chronic Subdural Hematoma (CSDH) is a common hemorrhagic disease in neurosurgery, and with the intensification of global aging, its incidence is gradually increasing. With the advancement of scientific technology, the etiological concepts and surgical treatments for CSDH have continually evolved over time. Currently, neuroscientists' understanding of CSDH is no longer confined to bridging vein rupture; exploration of various mechanisms such as angiogenesis, maturation of blood vessels, and inflammation is also underway. In-depth exploration and discovery of pathogenic mechanisms guide the updating of clinical treatment strategies and methods. For different types of CSDH, there is now a clear guidance for the targeted selection of treatment methods. However, the current treatment of CSDH cannot completely solve all problems, and the updating of treatment methods as well as the development and validation of new effective drugs remain challenges for the future. In addition, the recurrence of CSDH is a significant issue that needs to be addressed. Although we have reviewed potential recurrent factors that may be associated, the strength of this evidence is insufficient. Future research should gradually focus on validating these recurrent factors and exploring new ones, in order to optimize the existing understanding and treatment of CSDH.
BACKGROUND: To estimate and compare the association between metabolically healthy overweight/obesity (MHO) and the risk of type 2 diabetes (T2DM) among different ethnic groups in southwest China, while also exploring possible ethnic differences.
METHODS: This is a prospective cohort study of 6,820 participants in Southwest China. MHO was defined as body mass index (BMI) ≥ 24 kg/m2 and the presence of ≤ 1 component of metabolic syndrome. Cox proportional risk models were utilized to analyze the association between MHO and the risk of T2DM.
RESULTS: The median follow-up time was 6.58 years, during which 708 new cases of T2DM were diagnosed. In the total population, after adjusting for confounding factors, MHO was found to increase the risk of T2DM compared to metabolically healthy normal weight (MHNW) individuals (HR = 1.49, 95% CI: 1.15-1.93). Subgroup analysis by ethnicity revealed that, MHO increased the risk of T2DM in the Han population (HR = 1.64, 95% CI: 1.21-2.23), however, the difference was not statistically significant in the ethnic minority population.The results of sensitivity analysis further supported the robustness of these findings. Meanwhile, stratified by sex, age, and urban/rural, it was found that ethnic differences in the association between MHO and T2DM still existed, however, it is important to note that the association between MHO and T2DM was not statistically significant in the Han population subgroup aged ≥ 45 years (p > 0.05).
CONCLUSION: MHO was associated with an increased risk of T2DM compared to MHNW, and there are ethnic differences. Future interventions need to be strengthened for Han Chinese key populations to reduce the risk of T2DM.
Depressive symptoms and impaired self-care respectively occur in up to 58% and 80% of older hospitalized patients with heart failure, and each doubles the risk of rehospitalization. These two conditions are closely intertwined with shared core behaviors/experiences, i.e., hopelessness/negative expectation, loss of motivation, impaired problem-solving skills, and social isolation/poor social support. As such, integrated interventions that explicitly address both depressive symptoms and impaired HF self-care are more efficacious than interventions that focus on depressive symptoms or HF self-care alone. In separate studies, problem-solving therapy (PST) has been effective to improve depressive symptoms and self-care for heart disease in older adults, including those with mild cognitive impairment. Though promising, there is no evidence regarding PST efficacy in addressing both depressive symptoms and self-care in HF patients. This is due to 1) sample heterogeneity, as only 18% to 77% of the subjects in prior studies had HF, and 2) separate interventional foci, as HF information was not used to link depressed mood to impaired self-care. Characteristics of hospitalized HF patients such as timing and cognitive function were also not considered. The first three months after hospital discharge is the period when depressive symptoms are most likely to change and when impaired HF self-care is mostly likely to lead to rehospitalization. Moreover, more than half (54%) of older depressed HF patients have mild cognitive impairment that can lead to dementia, especially in the context of impaired self-care, uncontrolled HF and restricted cerebral blood flow. However, no PST interventions have been specifically provided in the post-discharge period or among HF patients with mild cognitive impairment. To date, there is no evidence regarding the efficacy of integrated PST interventions on both depressive symptoms and impaired self-care in HF patients after hospital discharge.

The ultimate goal of this research program is to prevent rehospitalization in HF patients using integrated PST interventions to simultaneously improve depressive symptoms and self-care. Built on the investigator's prior work with depressive symptoms in home health care (HHC), this study will examine the feasibility of a home-based, telephone-enhanced PST intervention (PST-HF) in these patients after hospital discharge.
B) "Real Life" Usability Testing. We will conduct a "real life" usability test in a sample of 6 pediatric cancer survivors. EX@HOME: Patients will perform an individualized aerobic and resistance exercise intervention, choosing from a list of PA, progressing from light to moderate-to-vigorous intensity totaling 30-45 min/d, 4-5 weekly/wk. for 4 weeks. The social-cognitive-theory-based mobile app will support the exercise intervention. One-on-one messaging chats with a PA coach through the mobile app will facilitate exercise goal establishment and attainment.
PURPOSE: A composition containing an alcohol extract of Hapalopilus rutilans is provided to suppress digestion and absorption of body fat, and to prevent or treat obesity. CONSTITUTION: A composition for preventing or treating obesity contains a C1-C10 alcohol extract of Hapalopilus rutilans as an active ingredient. The extract is prepared by extracting Hapalopilus rutilans with 90-99.9%(v/v) ethanol at 20-60 deg. C for 12-36 hours. A pharmaceutical product for preventing or treating obesity contains the extract as an active ingredient. A health functional food for preventing or treating obesity contains the extract as an active ingredient. A method for preventing or treating obesity comprises a step of administering the extract to animals exclusive of human. The extract suppresses activation of pancreatic lipase. [Reference numerals] (AA) TGL activity inhibition(%); (BB) Water extract (Comparative example); (CC) Ethanol extract
It consists of eight sessions that occur during app. 90 minutes. A group therapist and a cotherapist will lead the therapy sessions without using any psychological methods. There will be one session per a week.
FIELD: medicine. SUBSTANCE: the suggested composition includes EGF as an active ingredient and carboxyvinyl polymer as a foundation. It is established that EGF preparation is of considerable stability. Thus, the composition is useful as ophthalmologic compositions, composition for local application on skin, cosmetic compositions, etc. EFFECT: higher efficiency. 9 cl, 8 ex, 6 tbl
OBJECTIVE: To analyze cerebellar atrophy in genetic epileptic encephalopathies (EEs).
METHODS: This research included a retrospective cohort study conducted from January 2016 to December 2023 and a systematic review on cerebellar atrophy in genetic EEs. Pediatric individuals who were diagnosed with EEs based on electroclinical features, carried causative gene variants, and exhibited cerebellar atrophy were recruited. Electroclinical features, neuroimaging findings, and causative variants of eligible individuals were analyzed.
RESULTS: The cohort study showed 10 of 67 pediatric individuals (10/67; 15 %) who were diagnosed with genetic EEs had cerebellar atrophy; and 6 of the 10 individuals (6/10; 60 %) exhibited cerebellar signs. Diagnostic delay between the detection of cerebellar atrophy and the identification of genetic diagnosis existed in 6 individuals (6/10; 60 %) and the median duration was 4.4 years. A total of 32 genes, including 31 genes from the literature review and a newly identified SCN2A gene in this cohort, were reported associated with cerebellar atrophy in genetic EEs. Twenty-six genes (26/32; 81 %) accounted for cerebellar atrophy associated with other brain anomalies and 6 genes (6/32; 19 %) caused isolated cerebellar atrophy. Twenty-five genes (25/32; 78 %) showed late-onset cerebellar atrophy identified after the age of 1 year old.
CONCLUSION: Cerebellar atrophy is not uncommon in genetic EEs and may serve as an indicator for molecular diagnosis in clinical practice. To shorten the diagnostic delay, follow-up neuroimaging study is crucial because of high rate of clinico-radiological dissociation and late-onset cerebellar atrophy in this patient group.