anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a method applied to gene therapy of tumors. A gene medicament takes an adeno associated virus 8 (AAV8) of a serological type 8 as a vector and carries a destructive therapeutic gene (comprising a suicide gene) regulated and controlled by a micro RNA (Ribose Nucleic Acid) target sequence. The principle of treatment of hepatic tumor by using the gene medicament is that: the expression of the destructive therapeutic gene (suicide gene) carried by the gene medicament is regulated and controlled by endogenous microRNA of a hepatic cell, namely the expression of the destructive therapeutic gene of which the extraneous source is introduced by the AAV8 is regulated and controlled by the endogenous microRNA of the hepatic cell. In noncancerous tissues and cells, the cells do not express the destructive therapeutic gene under the regulation and control of the endogenous microRNA. When the destructive therapeutic gene is a TK gene, an expression product of the gene change a corresponding chemical medicament substrate into a medicament with killing effect on liver cancer cells so as to kill liver cancer tissues and cells; and the noncancerous tissues and cells do not express the suicide gene, so that the noncancerous tissues and cells are prevented from being killed and are protected. By adoption the method, the gene medicament can be administrated through peripheral veins, can reach the liver cancer tissues and cells in a liver in a targeting way, and expresses the destructive therapeutic gene in the liver cancer tissues, so that the aim of systematically treating liver cancer is finally fulfilled.
Hypertension is one of the major risk factors for morbidity and mortality worldwide. In this study, Mendelian randomization was utilized to investigate how dietary supplement intake can impact hypertension based on circulating plasma metabolite genome-wide association study (GWAS) datasets, protein quantitative trait loci (pQTLs) of plasma proteins, and multiple public summary-level GWAS data. Pathway enrichment analysis combined with the results of inverse variance weighted Mendelian randomization revealed that a lower risk of hypertension was associated with the dietary intake of glucosamine, an anti-inflammatory supplement: odds ratio (OR) (95% CI): 0.888 (0.824-0.958). Additionally, glucosamine 6-phosphate N-acetyltransferase was identified as a protective factor against hypertension, OR (95% CI): 0.995 (0.992-0.998), shedding light on the potential protective mechanism of glucosamine. Mediation Mendelian randomization indicated that the protective effect of glucosamine metabolism was mediated by glutaminyl-peptide cyclotransferase, with a mediation proportion of 12.1% (5.9-18.2%), p < 0.05. This study offers new insights into preventive strategies for individuals with hypertension risk.
End-stage renal disease (ESRD) is a critical condition and bears a high risk of cardiovascular events. However, clinical algorithms to identify patients with coronary vasculopathies are still not defined and standardized. Non-invasive imaging by myocardial perfusion scintigraphy (MPS) or dobutamine stress echocardiography (DSE) might be used in such patients, however, it is unclear if these provide complementary or identical information and how this correlates to coronary angiography. A direct comparison of these imaging approaches, excellently validated in coronary artery disease, has not yet been described in well-defined and large groups of ESRD patients.

The investigators therefore initiated a large prospective trial with 377 highly-selected and well-characterized end-stage renal disease patients without known coronary artery disease comparing the performance of standardized MPS and DSE. For the first time we here describe a significantly large proportion of ESRD patients with contradictory findings in MPS and DSE and its correlation to invasive coronary angiography hinting to complementary rather than identical information between both modalities. This is an excellent basis of future studies comparing the prognostic value of MPS versus DSE versus a combined MPS/DSE approach.
Naphthenic acids (NAs) are important pollutants in marine crude oils and have obvious toxic effects on marine organisms. However, the effects of NAs on the intestine are largely unknown. Thus, we evaluated the effects of NAs exposure in the intestines of marine medaka. Fish were experimentally exposed to NAs (0.5 mg/L, 5 mg/L, and 10 mg/L) for 96 h and monitored for changes in intestinal histology, markers of oxidative stress, and intestinal microbiome responses. Significant mucosal damage, inflammation, and oxidative stress were observed in the intestines of marine medaka after exposure to NAs. In addition, significant changes in the gut microbiota were observed. Specifically, the relative abundance of Proteobacteria decreased, while that of Verrucomicrobiota increased in the high-concentration exposure group. In addition, nutrient synthesis and metabolism in the gut were affected. The results of this study contribute to a better understanding of the ecological risk of different concentrations of NAs to marine organisms. CAPSULE ABSTRACT: Changes in the gut microbial community of marine medaka (Oryzias melastigma) caused by naphthenic acids in the marine environment were investigated through the assessment of gut inflammatory factors and comprehensive analysis using 16S rDNA high-throughput sequencing. The results indicated the induction of intestinal inflammation and changes in the structural composition of the intestinal flora.
The investigation was carried out over a period of 16 weeks, with 12 weeks dedicated to the RT program and 4 weeks allocated for measurements. Anthropometric, body composition, and blood samples measurements were performed at weeks 1-2, and 15-16. A supervised progressive RT was performed between weeks 3-14. The CG did not perform any type of physical exercise during this period.

Recruitment was carried out through newspaper and radio advertisings, and home delivery of leaflets in the central area and residential neighborhoods. All participants completed health history and physical activity questionnaires and met the following inclusion criteria: 60 years old or more, physically independent, free from cardiac or orthopedic dysfunction, not receiving hormonal replacement therapy, and not performing any regular physical exercise more than once a week over the six months preceding the beginning of the investigation. After individual interviews, 59 volunteers were dismissed as potential candidates because they did not meet the inclusion criteria for the investigation. The remaining 51 older women were randomly divided into one of two groups: a training group that performed the RT program or a control group that did not perform any type of physical exercise. Anthropometric, body composition (DXA), phase angle, total body water (intra and extracellular water compartments; Xitron 4200 Bioimpedance Spectrum Analyzer), muscular strength (1RM), and blood sample measurements were performed pre- and post-training. Two-way analysis of variance for repeated measures was applied for intra- and inter-group comparisons. When an F-ratio was significant, Fisher's post hoc test was employed to identify mean differences. The statistical power was determined to verify the statistical power of the analysis. Pearson's correlation was used to evaluate the correlation between delta percent changes in body composition, and muscular strength, inflammatory and oxidative stress biomarkers (independent variables) with the percentage change in PhA (dependent variables). Subsequently, linear regression (bivariate analyses) was performed for all variables that presented P\<0.05 in the Pearson's correlation analyses. For the multiple comparison the multivariate regression model was performed. For all statistical analyses, significance was accepted at P\<0.05.
Comprehensive Outpatient Management (COM) is the most realistic evidence-based comparator, in that it is the most frequently recommended and used option for US T2D patients. COM, like DTM, is consistent with the 2018 American Diabetes Association (ADA) Standards which include, but are not limited to, past medical and family history, social history, medications, screening, physical examination, laboratory evaluation, etc.Patients are instructed to monitor blood glucose (within physician recommendations), and have routine or "well" visits every 3 months. Patients can set appointments with a T2D educator. COM patients will receive monthly calls from the study Registered Nurse (RN) to collect data.
The invention belongs to the technical field of medicinal preparations and relates to a tilmicosin micelle preparation and a preparation method thereof. The tilmicosin micelle preparation comprises the following components in part by weight: 3 to 5 parts of tilmicosin, 5.0 to 15.5 parts of pharmaceutically acceptable carrier materials, 52 to 68 parts of poly(butylene succinate) (PBS ), 0 to 8 parts of additive and a pH modifier, wherein the pH value of the pH modifier is 5 to 7. In the tilmicosin micelle preparation, poloxamer 188 serves as the main micelle component. The poloxamer 188 is an asymmetric amphiphilic block copolymer and can automatically form the micelle in aqueous solution, wherein the hydrophobic block of the micelle gathers inwards and the hydrophilic block gathers outwards. Because the formed micelle is relatively smaller low in particle size, the micelle is higher in retention capability to an inflammatory part and stable onto heat and is not easy to oxidize. The entrapment rate and the drug loading capacity of the tilmicosin micelle preparation are high.
OBJECTIVE: This study aims to develop a predictive model for estimating the likelihood of anemia of chronic disease (ACD) in patients with systemic lupus erythematosus (SLE) and to elucidate the relationship between various factors and ACD METHODS: Individuals diagnosed with SLE for at least one year were enrolled and categorized into two groups: those with ACD and those without anemia symptoms. Patients were randomly assigned to training and test sets at an 8:2 ratio. The least absolute shrinkage and selection operator (LASSO) method was used to select predictors, followed by logistic regression for modeling. Model performance was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) for both training and test sets.
RESULTS: The study included a total of 216 patients, with 172 in the training set and 44 in the test set. LASSO identified 6 variables for constructing the predictive model, resulting in an area under the curve (AUC) of 0.833 (95% CI, 0.773-0.892) in the training set and 0.861 (95% CI, 0.750-0.972) in the test set. Calibration curves indicated consistency between expected and observed probabilities. DCA indicated that the model yielded a net benefit with threshold probabilities ranging from 20% to 90% in the training set and from 10% to 80% in the test set.
CONCLUSION: This study presents a predictive model for assessing the risk of ACD in SLE patients. The model effectively captures the underlying mechanism of ACD in SLE and empowers clinicians to make well-informed treatment adjustments. Key Points • Development of a New Predictive Model: This study introduces a new predictive model to evaluate the likelihood of anemia of chronic disease (ACD) in patients with systemic lupus erythematosus (SLE). The model utilizes routine laboratory parameters to identify high-risk individuals, addressing a significant gap in current clinical practice. • Reflection of Potential Mechanisms for ACD Development: By incorporating the factors needed to construct the predictive model, this study also sheds light on the potential mechanisms of ACD development in SLE patients.
A portable TENS unit (Gem-Stim, Gemore Technology Co., LTD. Taiwan) was used, and delivered a bi-phasic symmetric waveform at a continuous frequency of 100 Hz and phase duration of 200 µsec. The intensity was gradually adjusted up to a strong but comfortable l level, as reported by the subject. Two electrodes were placed 2 cm apart, respectively attached to the carpal ligament of the affected side and the proximal end along the direction of the median nerve.
The present invention discloses a traditional Chinese medicine for treating palpitation, which is prepared by the following components according to a certain proportion: pork heart, ginseng, red sage root, salt, Radix Astragali, Chinese angelica, Radix Rehmanniae Preparata and water. According to the technical scheme of the invention, the pork heart is added into the traditional Chinese medicine to lead the traditional Chinese medicine into the heart of a human body. Meanwhile, the Chinese angelica and the Radix Rehmanniae Preparata are added into the traditional Chinese medicine to enrich the blood. The ginseng and the Radix Astragali are added into the traditional Chinese medicine to tonify Qi. The red sage root has the effects of quickening blood, dispelling stasis, calming nerves, soothing hearts, and tonifying without causing stagnation. Therefore, the traditional Chinese medicine has a good effect on treating palpitation patients, and further prevents the occurrence of heart diseases. Meanwhile, the traditional Chinese medicine is free of any toxicity and side effects.
Pharmaceutical particulate formulations of the S-(+)- enantiomer of ibuprofen comprising i) 40-70 % w/w of S-(+)-ibuprofen, ii) a water-soluble pharmaceutically acceptable binder, iii) optionally, silica in an amount not exceeding 2 % w/w, with the proviso that the formulation does not contain water-soluble polyvinylpyrrolidone. The formulations have a relatively high load of S-(+)- ibuprofen and, accordingly, a relatively low content of excipients. The formulations exhibit good flowability, good compactability and possesses excellent tabletting properties. Thus, the formulations allow the preparation of, e.g., tablets which display minimal or greatly diminished adherence (sticking) to tablet punches and/or dies during compression, and which have excellent disintegration and dissolution properties and reduced tendency towards time-dependent reduction of dissolution rate. The water-soluble binder may be hydrophilic substances like, e.g., gelatin, starch or acacia. When silica is present in a formulation, colloidal silicas such as AerosilR 200, AerosilR 380, Cab-O-SilR M5, Cab-O-SilR EH5 or SyloidR have proved to be well suited. Furthermore, the invention relates to a process for the preparation of a formulation as mentioned above and to solid drug dosage forms comprising such a formulation.
A composite biomaterial (I) for preventing surgical tissue adhesions comprises at least one hyaluronic acid (HA) deriv. selected from (a) benzyl esters of HA in which 75-100% of the COOH gps. of HA are esterified with benzyl and up to 25% are esterified with 10-20C alkyl, provided that at least 80% of the COOH gps. are esterified; and (b) self-crosslinked HA derivs., in which 0.5-20% of the COOH gps. of HA are crosslinked to OH gps. of the same or different HA molecules. Also claimed is the use of (I) for preventing surgical adhesions and a method for preventing tissue adhesions using (I).
The invention discloses traditional Chinese medicine ultra-micro powder granules for preventing and treating necrotic enteritis of poultry and a preparation method thereof, and aims to provide a traditional Chinese medicine composition for preventing and treating necrotic enteritis of chickens caused by clostridium welchii. The traditional Chinese medicine ultra-micro powder granules comprise the following components in mass fraction: common andrographis herb, berberis root, purslane, myrobalam, stemona root, dark plum, astragalus root, licorice, medicated leaven and chicory. The components are pure natural traditional Chinese medicinal materials, resources are wide and sufficient, the preparation is easy, and the cost is low. After the components are subjected to ultra-micro grinding and prepared into the granules, the palatability can be increased. After the granules are mixed or taken by drinking water, the medical effects of the traditional Chinese medicines are increased, and the intestinal flora is regulated, so that the granules have a better curative effect on necrotic enteritis of poultry. Compared with currently common medicines, the granules have the advantages of high safety, good curative effect, no residue and the like and guarantee the animal-derived food safety and human body health, so that the granules are good products for treating necrotic enteritis of poultry.
Mother does NOT receive maternal RSVpreF and infant receives one dose of nirsevimab (BEYFORTUS) 50mg/0.5mL if body weight \<5kg or 100mg/mL if body weight is \>= 5kg at birth . N= 50.
TITLE OF THE INVENTION AVERMECTIN DERIVATIVES     ABSTRACT OF THE DISCLOSURE         There are disclosed novel avermectin .DELTA.-23,24-derivatives (also referred to as 23,24-dehydro compounds).  The compounds are prepared by selective dehydration of avermectin A2 or B2 compounds.  The avermectin compounds have utility as anti-parasitic agents and compositions for that use are also disclosed.  The compounds are also highly potent insecticides against agricultural pests.  The .DELTA. 23,24-avermectin compounds have increased activity relative to the A2 or B2 compounds.
Metachromatic Leukodystrophy (MLD) is a rare autosomal recessive disorder caused by the deficiency of the Arylsulfatase A enzyme (ARSA), resulting in accumulation of galactosyl sulfatide (cerebroside sulfate), a major constituent of the myelin sheath. Accumulation of galactosyl sulfatides leads to a progressive degeneration of the white matter in the central and peripheral nervous system (CNS, PNS) and neuronal degeneration. The late infantile form of MLD, which usually is diagnosed in the second year of life, is the most frequent and severe form of the disease. The prognosis is severe, leading to vegetative stage or death within few years after the diagnosis. There is no treatment for patients affected with this early onset form of the disease. In patients with late-onset MLD (juvenile and adult forms), allogeneic hematopoietic stem cell transplantation can stabilize the cerebral demyelination. This treatment is however inefficient in patients with late infantile MLD at a symptomatic stage. The overall objective is to evaluate the efficacy and safety of rhASA treatment in a patient with late infantile MLD who had received HCT at a presymptomatic stage of the disease. Patient will receive rhARSA (100 U/kg) intravenously every other week for a period of 18 months.
Cupping is an ancient alternative medicine. A common form of cupping, called dry static cupping, involves creating negative pressure inside a therapeutic cup. The cup is then placed on the skin, creating a light suction effect. In Eastern Medicine, cupping has been used to treat a variety of diseases. More recently, in Western society, cupping has been used after injury, and among other effects, has been found to improve blood volume and tissue oxygenation to an area. These effects have originally been thought to be peripheral in nature, occurring at the cupping site, hence, why cupping has been used for treatment for conditions like carpal tunnel syndrome, spinal pain, knee osteoarthritis, and other musculoskeletal conditions.

However, a recent systematic review found cupping to be beneficial for rehabilitation after stroke. These conclusions raise the question of a possible mechanism for cupping to improve impairments related to the central nervous system, such as spasticity after stroke. However, many of the studies to date have serious methodological flaws that limit the direct causation of cupping to the reduction of spasticity. As well, the majority of studies only involve the upper extremity. No study has yet looked at the therapeutic effects of dry static cupping on lower extremity spasticity reduction after stroke.
After being included in the patient, the EIT chest strap was worn to measure the end expiratory lung impedance and tidal impedance variable, assess the distribution of lung ventilation in patients and record GI index and CoV. EELI,TIV, GI index, CoV, vital signs of patients, including heart rate, blood pressure, respiratory rate, SpO2, ventilator parameters, including mode, driving pressure, FiO2, PEEP, and lung compliance was recorded before and after bronchoscopy. Patients underwent a recruitment maneuver 5 minutes after bronchoscopy maintaining breaths at a PC of 40 cm H2O with PEEP of 20 cm H2O in pressure control mode for 1 minute, then, PEEP was decreased from 20 to preceding PEEP value in steps of 2 cm H2O with a duration of at least 10 breaths or 30 seconds at each step.
In the intervention group, students will participate in 6 health promoting video sessions and three sessions will be delivered by trained facilitators per month. The session will be 30 to 40 minutes and the intervention will be provided over two months. The video material will be focused on the leading risk factors associated with NCDs as reported by different studies such as physical inactivity, unhealthy diet and overweight, obesity, harmful alcohol consumption and tobacco use.
PURPOSE:To obtain a skin cosmetic containing 7-dehydrocholesterol as an active ingredient, having skin pigment deposition forming action and providing dense sunburn in low dose while preventing inflammation. CONSTITUTION:7-Dehydrocholesterol is contained as an active ingredient. The ingredient is blended into a cosmetic, preferably at an amount of 0.001-10wt.%. The cosmetic is produced in form of cosmetic water, cosmetic oil, cream, emulsion, pack, powder, etc., by a well-known method. Further, as necessary a well- known ingredient can blended into the cosmetic in the range free from impairing performance according to the series. The cosmetic prevents skin disease such as burn by excess insolation or skin irritation and effective sunburn is obtained only by exposing to the sun's rays at a short time.
Compounds with the formula: < IMAGE > in which R1 and R2 represent independently, a linear or branched alkyl, cycloalkyl, phenylalkyl or cycloalkylalkyl group. R1 and R2 may also represent an alkenyl or alkynyl group. R1 and R2 may also represent a group of the formula -R3-Z-R4 in which R3 represents an alkylene group, on condition that at least 2 carbon atoms separate the nitrogen atom from the group Z R4 represents an alkyl group, and Z an atom of oxygen, sulphur or the group >N-R5, R5 representing a hydrogen atom or an alkyl group. R1 and R2 may form, with the nitrogen atom to which they are attached, a heterocyclic ring. Ar represents a phenyl, pyridyl or thienyl group, or a substituted phenyl group, A and B representing independently, N or CH-, the group C representing the residue of a benzene or thiophene ring. These compounds can be used as medicaments, in particular, for the various applications of benzodiazepines.