anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the medicine field, particularly to Xuanmai Ganjie puffed granules and a preparation method thereof. The invention provides Xuanmai Ganjie puffed granules with good flowing characteristics and a ball-like shape. The extraction or decocting technology can be performed according to the present method during the granulating process. The main difference between the method in the invention and the present method is making the granules in a compressed state. In the process of drying the granules, the moisture of the granules is controlled at 4-5 percent, then the granules are heated at high temperature to become puffed and the finished products of the granules are obtained by drying the puffed granules. The preparation method of the invention can form ball-like granules with smooth surfaces and compact texture. The interiors of the granules have a phenomenon of cavitation expansion which enables the granules to have good shape and not-easily-broken property, An angle of repose of a granule is between 10 degree to 25 degree. The granules prepared by the method have characteristics that the granules have good fluidity, do not easily absorb moisture and require less auxiliary material. Besides, the paste material is hard to appear when the granules are mixed with water, so that the mixing is very easy. The Xuanmai Ganjie puffed granules of the invention can be used as a raw material for preparing tablets and capsules according to the ordinary technology of compressing tablets and stuffing capsules.
A bioreactor is disclosed that can be used to study living tissues (e.g., lung tissues) in an environment that mimics the natural environment. Pressure, flow and force modules enable imitation of in vivo conditions. An integrated imaging module allows for the airway tissues and cells of interest to be visualized and monitored continuously and non-destructively at the single-cell level. A method of use of the created systems can be utilized to quantify mucociliary fluid movements across the luminal surface of in vitro-cultured human airway tissue via in situ particle tracking and analysis is also disclosed. Another method of use of systems created in accordance with an embodiment of the present invention is to generate in vitro-cultured human airway tissue with severely impaired mucociliary flow by depositing thick viscous mucus-mimetic fluid on to the airway lumen. Methods of de-epithelialization and replacement of living cells are also disclosed.
A cesarean section is a surgical procedure and, like all surgeries, there is pain after the operation. The purpose of this study is to find out if patients have less pain after a cesarean delivery when they receive an injection of local anesthetic on either side of their abdomen, into the plane of the transversus abdominis muscle. We are also interested in whether or not this injection decreases the need for other pain-killing medication during this time.

Patients will randomly be assigned to receive either local anesthetic or a placebo. In addition, all patients will receive the usual standard of care and medication for pain. At 6, 12, 24 and 48 hours after the operation, patients will be asked about their pain and satisfaction with pain management. The risk of side effects is very low, as the block is done in an area with low blood supply. We propose that the addition of the TAP block to the current multi-modal regimen of post-cesarean pain management will reduce pain scores and requests for additional analgesia post-operatively, as well as increase patient satisfaction with their pain control.
FIELD: medicine, immunology, genetic engineering, pharmacy. SUBSTANCE: invention relates to murine monoclonal anti-idiotypic antibody BR 55-2 Ab2 that is a substitute of antigen Lewis Y6. Antibody is prepared by means of hybridoma technology using conjugate of fragment F(ab')2 JgG63 BR 55-2 of mouse as an antigen. Prepared anti-idiotypic antibody is used for prophylactic or therapeutic immunization against diseases accompanying with expression of antigen Lewis Y6 and as a component in curative- -prophylactic pharmaceutical composition also. Prepared anti-idiotypic antibody is used for quantitative determination of monoclonal antibody with specific binding BR 55-2 and for one-step immunoaffinity purification of variant BR 55-2 of antibody. The usage of invention provides prophylaxis of HIV-infections, cancer of epithelial origin and cancer of lung small cells and their treatment also. EFFECT: improved preparing method, valuable medicinal properties of antibody. 10 cl, 39 dwg, 4 tbl, 23 ex
FIELD: cosmetology; may be used for prevention of dandruff on head skin. SUBSTANCE: lotion is prepared on the base of extracts of vegetable raw material including origanum. Used as an extractant is aqueous-alcoholic liquid with alcohol concentration of 60-75% at the rate of 0.5-3.0 g of raw material per 100 ml of extractant. Additionally, raw material contains lungwort and willow bark, while lotion is additionally has glycerin, recinox, ethyl alcohol, citric acid, flavor and water. All components are taken in preset quantitative ratio. Vegetable raw material for lotion contains origanum, willow bark, lungwort stems, leaves and flowers. EFFECT: restoration of metabolism of hair-covering and dandruff removal. 2 cl, 1 ex
Magnetic Resonance Imaging (MRI) has become an important tool in the diagnosis of inflammatory CNS diseases such as Multiple Sclerosis (MS) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM-TSP). It is widely used as a marker for disease activity and progression. However, conventional MRI methods are only suitable to study gross anatomical features, such as size and shape of a particular area of the brain; questions regarding intrinsic microstructure and morphologic specificity cannot be addressed. But axonal damage or structural abnormalities even in normal appearing brain tissue may play an important role in the development of irreversible disability. Magnetization Transfer Imaging, Magnetic Resonance Spectroscopy and Diffusion Tensor MRI are imaging techniques described to be capable of the detection of such changes. Spectroscopy can detect molecular components in tissue, whereas the Magnetization Transfer Ratio (MTR) allows the measurement of water-macromolecule interactions. Diffusion Tensor MRI (DT-MRI) is an imaging modality that combines features of in vivo anatomical MRI and histopathology: it is an in vivo MRI method that provides information about tissue composition, microstructure, organization and architecture. This is possible because water diffusion properties in tissues, as measured by DT-MRI, are affected by tissue constituents, such as macromolecules, membranes, organelles, as well as by tissue microstructure, architecture and organization. A study comprising Magnetization Transfer-, Spectroscopy- and DT-MRI furnishes important information that cannot be obtained using conventional MRI methods.
Each participant will have three data collection periods. Each data collection period will last one shift rotation (5 -7 days): One 5-shift or 7-shift block of Orbit 1 night shifts on console with access to photic and exercise countermeasures, a second 5-shift or 7-shift block of Orbit 1 night shifts on console with no access to countermeasures, and a third 5-shift block of daytime office work off console. We will be measuring sleep via a wrist worn activity measuring device and compliance of exercise intervention via a small, commercially available heart monitor worn around the chest underneath clothing. The activity device will be worn continuously and the heart monitor will be worn on shift. These devices will be downloaded at the end of each block of shifts. Subjects will complete a short baseline questionnaire once at the beginning of the study. Subjective alertness will be assessed with the Karolinska Sleepiness Scale (KSS), performance testing will occur regularly and 'end of shift' questionnaires will be completed at the end of each shift. Drowsiness will be measured on the commute to and from work with the Optalert.
This study aimed to explore the short-term effects of percutaneous endoscopic transforaminal decompression (PETD) for the treatment of symptomatic double-level lumbar spinal stenosis (LSS) with ossification. Twenty-eight patients diagnosed with double-level lumbar spinal stenosis who underwent double-level PETD surgery between January 2021 and January 2023 at our institution. General information, such as age, sex, disease duration, hospitalization time, and operation time, was recorded. Magnetic resonance imaging (MRI) dural sac cross-sectional area (DSCA) was recorded to assess the degree of spinal canal decompression. The White-Panjabi scoring system (WP) was used to assess preoperative and postoperative lumbar spine stability. Pre- and postoperative visual analog scale (VAS) and Oswestry Disability Index (ODI) scores were recorded to assess symptom improvement, and surgical efficacy was evaluated using the modified Macnab evaluation criteria at the 1-year postoperative follow-up. The types and risks of complications were also recorded. The patient's 1-year postoperative follow-up MRI showed that both L3/4 and L4/5 DSCA were significantly enlarged compared with preoperative values (P < .001). There was no significant difference in the WP scores at 3 months postoperatively compared with those preoperatively (P > .05). The VAS scores for hip and lower extremity pain at 3 days, 3 months, and 1 year postoperatively were significantly lower than those preoperatively (P < .001), and the ODI scores at 3 months and 1 year postoperatively were significantly lower than those preoperatively (P < .001). There were no significant differences in hip pain, lower extremity pain VAS scores, or ODI scores between the postoperative follow-up time points (P > .05). There was 1 case of lower limb numbness and 1 case of neuroedematous pain in the postoperative period, and all patients had no complications, such as dural sac tear, infection, or recurrence. The 1-year postoperative follow-up was assessed as excellent in 17 cases, good in 9 cases, and possible in 2 cases using the modified Macnab criteria, with an excellent rate of 92.9%. The efficacy of double-level PETD for symptomatic double-level LSS is clear, the local stability of the lumbar spine is less affected, and the risk is low, which can reduce the chances of reoperation in patients. Thus, it is a recommended surgical procedure.
The invention provides genes as predictive biomarkers of statin-induced muscle toxicity. Following statin administration, three types of skeletal muscle (soleus, gastrocnemius and extensor digitorum lateralis (EDL)), including fast-twitching and slow-twitching, were profiled and analyzed. Remarkably, for samples exhibiting myopathy, the three muscle types showed highly similar gene expression profiles. Genes involved in oxidation, apoptosis, and ubiquitin-dependent protein catabolism and proteolysis were significantly changed, suggesting extensive protein degradation. In addition, significant induction of genes involved in the regulation of glycolysis and fatty acid oxidation, such as PDK4, 6-phosphofructo-2-kinase, and acetyl-Coenzyme A carboxylase beta, were also observed. PDK4 phosphorylates and inactivates the pyruvate dehydrogenase complex, and is the key inducer of the metabolic switch from glycolysis to fatty acid oxidation.
PROBLEM TO BE SOLVED: To obtain an antipyretic and an analgesic agent having excellent feeling of administration and flavor. SOLUTION: This antipyretic and analgesic agent contains an antipyretic and analgesic ingredient selected from ibuprofen, acetaminophen, oxaprozin, loxoprofen, ketoprofen and fenbufen and Stevia Rebaudiana Bertoni as a sweetness ingredient. The effective amount of the blended Stevia Rebaudiana Bertoni is 5-100mg, preferably 10-50mg for a healthy adult. The amount of the blended Stevia Rebaudiana Bertoni is 0.001-0.1 pt.wt., preferably 0.007-0.03 pt.wt. based on 1 pt.wt. ibuprofen, depending on the antipyretic and analgesic ingredient. A usually used additive is further suitably blended to formulate the agent into a pharmaceutical preparation for peroral administration. The antipyretic and analgesic agent is relatively stable to heat and acids, has high stability and can be used without any anxiety.  The agent has a mild quality of the sweetness and a slight aftertaste and is nonfermentative without causing browning actions by heat treatment.
Bilateral, split-face comparison in which one half of the face will be randomly assigned to receive the microdermabrasion treatment(s) while the other half of the face will not. Subjects will receive a series of microdermabrasion treatment sessions (up to 6) spaced one to two weeks apart. In all cases, microdermabrasion treatment parameters will be within those accepted in cosmetic work.
The present invention relates to a joint hot compress bag which can treat arthritis. The joint hot compress bag is characterized in that the joint hot compress bag is made of the medicament raw materials of the following parts by weight: 13 to 17 parts by weight of lycopodium clavatum, 13 to 17 parts by weight of caulis impatientis, 8 to 12 parts by weight of erythrina bark, 8 to 12 parts by weight of pawpaw, 8 to 12 parts by weight of ledebouriella root, 8 to 12 parts by weight of cortex illicii, 8 to 12 parts by weight of pubescent angelica root, 8 to 12 parts by weight of red peony root, 8 to 12 parts by weight of safflower, 8 to 12 parts by weight of rhizoma drynariae, 8 to 12 parts by weight of frankincense, 8 to 12 parts by weight of dahurian angelica, 8 to 12 parts by weight of achyranthes root, 8 to 12 parts by weight of cassia twig, 8 to 12 parts by weight of atractylodes, 3 to 7 parts by weight of zanthoxylum piperitum, 8 to 12 parts by weight of table salt and 8 to 12 parts by weight of peach seed. The preparation method of the present invention comprises the following steps: all the raw materials are weighed for use; the raw materials are pulverized into coarse particles; the coarse particles are respectively put into two thin cloth bags whose length is 15cm and width is 11cm, and the thin cloth bags are sutured. When in use, a right amount of spirit is poured on the medicine bags (namely the thin cloth bags) to moisten medicaments in the medicine bags, and the medicine bags are put into a pot to be boiled for ten minutes in a water separation mode. First, one medicine bag is taken out to be cooled; second, the temperature of the medicine bag reaches temperature which can be bore by a human body, the medicine bag is applied to an affected part; finally, a heat insulation cloth pad is covered on the medicine bag. After the medicine bag is not hot, the other medicine bag can be used. The two medicine bags are alternately used, each time is from 40 to 60.
BACKGROUND: Postoperative pain is a prevalent symptom experienced by patients undergoing surgical procedures. This study aims to develop deep learning algorithms for predicting acute postoperative pain using both essential patient details and real-time vital sign data during surgery.
METHODS: Through a retrospective observational approach, we utilized Graph Attention Networks (GAT) and graph Transformer Networks (GTN) deep learning algorithms to construct the DoseFormer model while incorporating an attention mechanism. This model employed patient information and intraoperative vital signs obtained during Video-assisted thoracoscopic surgery (VATS) surgery to anticipate postoperative pain. By categorizing the static and dynamic data, the DoseFormer model performed binary classification to predict the likelihood of postoperative acute pain.
RESULTS: A total of 1758 patients were initially included, with 1552 patients after data cleaning. These patients were then divided into training set (n = 931) and testing set (n = 621). In the testing set, the DoseFormer model exhibited significantly higher AUROC (0.98) compared to classical machine learning algorithms. Furthermore, the DoseFormer model displayed a significantly higher F1 value (0.85) in comparison to other classical machine learning algorithms. Notably, the attending anesthesiologists' F1 values (attending: 0.49, fellow: 0.43, Resident: 0.16) were significantly lower than those of the DoseFormer model in predicting acute postoperative pain.
CONCLUSIONS: Deep learning model can predict postoperative acute pain events based on patients' basic information and intraoperative vital signs.
The invention relates to a dendrobium nobile wine capable of nourishing yin and tonifying kidney and a preparation method thereof. The dendrobium wine for nourishing yin and tonifying kidney comprises the following raw materials in parts by weight: 10-12 parts of dendrobium, 15-18 parts of rhizoma polygonati, 30-36 parts of medlar, 500-600 parts of glutinous rice and 3.3-3.6 parts of distiller's yeast. The dendrobium officinale wine for nourishing yin and tonifying kidney takes dendrobium officinale as a monarch drug and is mainly used for strengthening yin and tonifying kidney; medlar is a ministerial drug, and dendrobium is used as an adjuvant drug for replenishing vital essence, treating nephropathy and nourishing kidney; rhizoma Polygonati is used as a guiding drug to enhance the spleen and stomach power and improve tiredness and hypodynamia. Has effects of nourishing yin, invigorating kidney, invigorating spleen, moistening lung, relieving fatigue, resisting oxidation, improving eyesight, and enhancing immunity. In addition, the added raw materials such as the medlar, the sealwort, the dendrobium and the like can improve the color and luster of the wine, so that the wine has bright deep red color and the organoleptic properties of the wine are improved. The preparation method of the dendrobium wine for nourishing yin and tonifying kidney has easily controlled process and is beneficial to large-scale production.
FIELD: medicine, surgery. SUBSTANCE: one should remove the part of rectum together with tumor per peritoneum. Sigmoid flexure is descended into anus to direct it through intact anal canal. In 10-14 d excessive part of sigmoid flexure is dissected to apply sigmoanal anastomosis. Moreover, sigmoid flexure is connected "end-to-end" with anal canal mucosa. At descending sigmoid flexure it should be fixed to rectal stump. Rectal stump mucosa is dissected being distally against resection line of muscular membrane. Before dissecting mobilized complex one should wash rectal stump with 5-fluorouracil and alcoholic solution of chlorohexidine. The method enables to decrease the possibility for development of abscesses and phlegmons as a result of feces availability in pelvic cavity. EFFECT: higher efficiency. 1 ex
Examples of a wearable electronic system are described. The system comprises a sensor array and a data acquisition (DAQ) system comprising a processing module. The processing module receives a user identifier associated with the user, and sensor data from the sensor array. The processing module analyses the sensor data to determine a set of transient state sensor data from sensor data. The sensor data may be analysed based on the user identifier and a state of the sensor array. The processing module filters out the set of transient state sensor data from the plurality of sensor data to obtain steady state sensor data and causes to store the steady state sensor data.
The present study provides the next important step for this line of research. First, the present study is a far more developed examination of the potential effects of BCT on multiple dimensions of youth functioning, taken from multiple perspectives. Second, we do not know "how" BCT works. The positive effects of BCT on parents (reduced addition severity, improved dyadic adjustment, reduced partner violence, improved parenting, and improved parental psychological adjustment) may have positive "trickle down" effects on youth; however, we have not undertaken an empirical examination of these potential mechanisms of action. If we can understand how it works, we will be able to use that information to refine BCT to enhance the mechanisms that benefit youth. Thus, the present study will examine possible curative mechanisms. Third, we have a very limited understanding for "whom" it works. Thus, we will examine whether BCT may operate differently for children of different stages of development. If we can understand this moderating effect, we may be able to develop and refine BCT to meet the needs of families with children of different ages.

To address these issues, the present study will compare the emotional and behavioral adjustment, beliefs, and behaviors, including serious problem behaviors, of youth ages 5 to 18 (as rated by mothers, fathers, and the children themselves) whose mothers or fathers take part in BCT to an Intent-to-Treat group. We will focus on potential mechanisms of action that are positively influenced by BCT.

We intend to use the information collected from the proposed investigation to refine and modify BCT to enhance its positive effects on children. This process of (a) examining multiple dimensions of functioning and (b) evaluating theoretically and empirically identified mediators and moderators to inform intervention development and refinement has been used successfully for over a decade with BCT, resulting in empirically informed BCT variants for alcoholic patients, drug-abusing patients, patients who engage in domestic violence, female substance-abusing patients, and so on. Thus, this project provides the next critical step for BCT refinement and interventions for couples entering BCT who have custodial children, the latter of whom we may only be able to help by helping their parents.
Dupuytren's disease is characterised by retractile fibrosis of the superficial palmar aponeurosis that can result in irreversible flexing of the fingers and long-term disability. The treatment of Dupuytren's disease, whether medical or surgical, remains symptomatic. It is based in Europe on percutaneous needle aponeurotomy and surgical aponeurectomy. Its objectives are the reduction of the deformity of the fingers in flexum, and that of the incapacity that generates the illness. Percutaneous needle aponeurotomy for Dupuytren's disease was developed by Jean-Luc Lermusiaux in 1972 in the Rheumatology Department of the Lariboisière Hospital in Paris. Its efficiency, its tolerance, its simplicity, its low cost and the possibility of repeating it make it a benchmark treatment. Percutaneous needle aponeurotomy is, for many, if the existence of this technique is known and understood, the first-line treatment of Dupuytren's disease.

As part of a graduated medical-surgical strategy, and in our practice, surgery for Dupuytren's disease appears as a second-line treatment indicated in a situation of failure after treatment with percutaneous needle aponeurotomy. The safety and efficacy of the surgery was evaluated in the context of a first-line treatment of Dupuytren's disease. The results of second-line surgery in terms of safety and efficacy have not been specifically evaluated in patients who underwent failed percutaneous needle aponeurotomy. This evaluation nevertheless appears necessary for the validation of a medical-surgical strategy during Dupuytren's disease.
This is a prospective natural history study examining the phenotypic variations of individuals with mutations in MECP2 or meeting the diagnostic criteria for classic (typical) or variant (atypical) Rett syndrome. The overwhelming majority will be female, but males meeting diagnostic criteria will be included. No interventions are planned.