anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Read this leaflet before taking Cytotec® (misoprostol) and each time your prescription is renewed, because the leaflet may be changed.

Cytotec (misoprostol) is being prescribed by your doctor to decrease the chance of getting stomach ulcers related to the arthritis/pain medication that you take.

Do not take Cytotec to reduce the risk of NSAID-induced ulcers if you are pregnant. (See boxed WARNINGS.) Cytotec can cause abortion (sometimes incomplete which could lead to dangerous bleeding and require hospitalization and surgery), premature birth, or birth defects. It is also important to avoid pregnancy while taking this medication and for at least one month or through one menstrual cycle after you stop taking it. Cytotec may cause the uterus to tear (uterine rupture) during pregnancy. The risk of uterine rupture increases as your pregnancy advances and if you have had surgery on the uterus, such as a Cesarean delivery. Rupture (tearing) of the uterus can result in severe bleeding, hysterectomy, and/or maternal or fetal death.

If you become pregnant during Cytotec therapy, stop taking Cytotec and contact your physician immediately. Remember that even if you are on a means of birth control it is still possible to become pregnant. Should this occur, stop taking Cytotec and contact your physician immediately.

Cytotec may cause diarrhea, abdominal cramping, and/or nausea in some people. In most cases these problems develop during the first few weeks of therapy and stop after about a week. You can minimize possible diarrhea by making sure you take Cytotec with food.

Because these side effects are usually mild to moderate and usually go away in a matter of days, most patients can continue to take Cytotec. If you have prolonged difficulty (more than 8 days), or if you have severe diarrhea, cramping and/or nausea, call your doctor.

Take Cytotec only according to the directions given by your physician.

Do not give Cytotec to anyone else. It has been prescribed for your specific condition, may not be the correct treatment for another person, and would be dangerous if the other person were pregnant.

This information sheet does not cover all possible side effects of Cytotec. This patient information leaflet does not address the side effects of your arthritis/pain medication. See your doctor if you have questions.

Keep out of reach of children.

This product's labeling may have been updated. For the most recent prescribing information, please visit www.pfizer.com.

LAB-0172–4.0  
Revised February 2021
PURPOSE:To obtain the titled composition which can be stored without causing the expansion and rupture of the packaging bag, by using a compound added with hydrogen peroxide and a chlorinated isocyanuric acid having specific particle size, as essential components. CONSTITUTION:The objective composition contains (A) a compound added with hydrogen peroxide (e.g. monohydrate of sodium percarbonate or sodium perborate) and (B) a chlorinated isocyanuric acid (e.g. an alkali metal salt of a chlorinated isocyanuric acid such as the sodium of a chlorinated isocyanuric acid), as essential components. The particle diameter of the chlorinated isocyanuric acid used as a raw material is 75-1,000mu, and the mixture is granulated to obtain a foamable granular composition having storage stability. It can be used in the form of granule or tablet. The amount of the chlorinated isocyanurate is preferably 5-500pts.wt. per 100pts.wt. of the compound added with hydrogen peroxide. The generation of the decomposed gas is slow, and stops as a definite level.
BACKGROUND: As a nutritional indicator, a lower level of geriatric nutritional risk index (GNRI) has been suggested as a predictor for poor prognosis in acute coronary syndrome (ACS). However, whether GNRI could improve the predictive value of the Global Registry of Acute Coronary Events (GRACE) score for the prognosis in elderly patients with non-ST segment elevation myocardial infarction (NSTEMI) after PCI remains unclear.
METHODS: A total of 446 elderly patients with NSTEMI after percutaneous coronary intervention (PCI) were consecutively enrolled. Patients were divided into major adverse cardiovascular and cerebrovascular events (MACCE) group and control group according to the occurrence of MACCE during one year follow up. The clinical parameters including GNRI were compared to investigate the predictors for MACCE. The performance after the addition of GNRI to the GRACE score for predicting MACCE was determined.
RESULTS: A total of 68 patients developed MACCE. In unadjusted analyses, the rate of MACCE was significantly higher in the 93.8<GNRI <102.7 group and GNRI ≤ 93.8 group versus GNRI ≥ 102.7 group. The logistics regression model showed that age, GNRI, and GRACE score were independent predictors for MACCE in elderly patients with NSTEMI after PCI. The addition of the GNRI to the GRACE score significantly improved the prediction of MACCE in elderly patients with NSTEMI after PCI, increasing the C-index from 0.792 to 0.885 (p < 0.001); the NRI was 0.094 (95% CI, 0.004-0.177, p < 0.001), and the IDI was 0.011 (95% CI, 0.000-0.023, p < 0.001).
CONCLUSION: Combining GNRI and GRACE score could significantly improve the predictive value of one year MACCE in elderly patients with NSTEMI after PCI. By using this combined new risk model, we could easily identify the high-risk populations in clinical practice, so as to better monitor and manage them.
Immersion pulmonary edema (IPE) is a condition that has sudden onset in swimmers and divers, and is characterized by cough, shortness of breath, decreased blood oxygen levels, and hemoptysis. The purpose of this study is to examine the effects of cold water immersion and the dive reflex on pulmonary arterial pressure and pulmonary capillary wedge pressure in those who have already experienced IPE, as well as explore the possibility of a genetic predisposition. Healthy nonsmoking subjects who have experienced IPE will be recruited for several cold-water immersion experiments and DNA analysis. Their pulmonary arterial and pulmonary arterial wedge pressures will be measured as they undergo immersed rest and exercise trials in thermoneutral and cold water. If the pressures increase with these trials as hypothesized, the effects of sildenafil administration (a pulmonary vasodilator) will be tested during a second trial. Blood will also be drawn for DNA analysis of certain genes with possible relation to IPE. Results of these tests will be compared with those of the general population.
Those randomised to receive the online programme will be given log-in details and a password, and instructions to begin the 6 week programme at home. The online programme mirrors the conventional face-to-face PR programme and the exercise and educational components are given by means of instructional videos. Participants will be instructed to exercise five times a week. Participants in the online arm will receive during the PR course telephone contact to record any adverse or serious adverse events.
There is evidence of the effect of probiotic intake on the immune system. However, the effect probiotics may have on the rate of aging is unknown. The aim of this study is to determine the effect of a probiotic blend on immunity, redox state, inflammation, and the rate of aging or biological age. A group of 10 men and 14 women took, daily for 2 months, a sachet with three probiotics (Bifidobacterium animalis subsp. lactis BSO1, Lactobacillus reuteri LRE02, Lactobacillus plantarum LP14) and vitamin D. Before starting the treatment and after 2 months, peripheral blood was collected. Immune functions were assessed in isolated immune cells, and cytokine concentrations were also measured both in mononuclear cell cultures and plasma. Redox state parameters were also analyzed in whole blood cells. Finally, the Immunity Clock was applied to determine the biological age. Results show that the intake of this probiotic blend in general, in both men and women, improves immunity and decreases the oxidative and inflammatory state. In addition, it rejuvenates the biological age by 10 years on average. It can be concluded that this probiotic blend could be proposed as a good strategy to slow down the aging process, and to achieve healthy aging.
WHEREIN R is as defined above, are produced. These compounds exhibit potent cardiotonic activity. Bronchodilating and vasodilating activity of these compounds are considerably low. Pharmaceutically acceptable acid addition salts of these compounds are also within the scope of the invention.   WHEREIN R is hydrogen or methyl. The resultant intermediate product is subjected to catalytic hydrogenation. 3,4-dihydroxybenzylalcohol compounds of the formula:   A 3,4-dibenzyloxyphenyl-glyoxal is condensed with 3,4,5trimethoxyphenethylamine compound of the formula:
Over 700 syndromes associated with hearing loss (HL) have been identified. Labyrinthine aplasia, microtia, and microdontia (LAMM syndrome, OMIM: 610706) is a rare HL syndrome characterized by congenital sensorineural HL, labyrinthine aplasia, type I microtia and microdontia, which is caused by biallelic variants in the FGF3 gene. Using Whole-exome sequencing (WES), we identified a novel missense FGF3 variant (c.137G > C, p. Arg46Pro (NM_005247.4) in three unrelated Uyghur ethnic families. This variant is classified as a variant of uncertain significance according to ACMG guidelines, with the applied criteria of PM3, PM2_Supporting, PP3 and PP4. Patients from the three families revealed variable clinical features. We found a novel phenotype, sparse hair, in one of the proband. Our findings expanded the variant and phenotype spectrum of LAMM syndrome and provided new insights to the diagnose and pathogenesis investigation of the disease.
1,187,214. Venetian blinds. HUNTER DOUGLAS INTERNATIONAL Ltd. 17 July, 1967 [15 July, 1966], No. 32776/67. Heading E1J. In a venetian blind comprising a slat lifting, lowering and tilting mechanism operated by a single hexagonal shaft 3 the ladder tapes 10, 11 are attached at each end to the ends 8, 9 of a helical spring 7 wound on an axial cylindrical portion 6 of a winding drum (5) on the shaft 3 for the lift straps 4, the weight of the ladders and their slats causing the helical spring to tighten on the portion 6 so as to turn with the shaft 3 until the end 8, or 9 of the spring encounters a fixed stop 13 or 14 on the supporting frame 1 whereupon the spring is slackened and the portion 6 slides past on continued rotation of the shaft in the lifting or lowering operation of the blind. The stops 14 may be removable to different positions, e.g. in the form of a peg in one of a series of holes (Figs. 3 and 4) and spring clutches may be provided on portions 6 on both sides of the lifting and lowering drum (5) the corresponding spring ends being connected by linear or U-shaped bars which support the ladder tape.
Participants will receive induction as azacitidine on days 1-7, venetoclax aily on days 1-28, cytarabine q12h on days 1-7, aclacinomycin on days 1,3,5,7, and granulocyte colony-stimulating factor on days 0-8. Participants will receive second induction if not reach complete remission.
A drug delivery device capable of forming a medicated mist that reaches the nasal and paranasal sinus cavities contains a puncturing element within its canister. The puncturing element is used in combination with a compartment that contains a filling. The compartment is optionally detachable from an interior of the device or entirely separate from the device. The puncturing element punctures the compartment, releasing the filling into the reservoir of the device to provide a medicated liquid. The device may store any form of medication so long as the medication remains stable. When dry powder forms are desired, the reservoir and/or compartment may be filled with a solution or diluent so as to form the medicated liquid, which may then be dispensed as a mist through the device following the puncturing.
Mitochondria, as an endosymbiont of eukaryotic cells, controls multiple cellular activities, including respiration, reactive oxygen species production, fatty acid synthesis, and death. Though the majority of functional mitochondrial proteins are translated through a nucleus-controlled process, very few of them (∼10%) are translated within mitochondria through their own machinery. Germline and somatic mutations in mitochondrial and nuclear DNA significantly impact mitochondrial homeostasis and function. Such modifications disturbing mitochondrial biogenesis, metabolism, or mitophagy eventually resulted in cellular pathophysiology. In this chapter, we discussed the impact of mitochondria and its dysfunction on several non-communicable diseases like cancer, diabetes, neurodegenerative, and cardiovascular problems. Mitochondrial dysfunction and its outcome could be screened by currently available omics-based techniques, flow cytometry, and high-resolution imaging. Such characterization could be evaluated as potential biomarkers to assess the disease burden and prognosis.
Using a previous cohort from the Limoges Hospital, the investigators have identified by multi-parametric flow cytometry phenotypic, cytokine and signaling molecules that are altered in NK cells from CHB patients during the inactive phase. Phenotypic changes observed include the downregulation of CD160, NKp30, CD16 and Tim-3. The expansion of 'adaptive' NK cells (FCεRg- NKG2C+ or CD57hi), and the upregulation of CD107a (steady state), NKG2D and 41BB. Functional changes include the decrease in the levels of IFNγ, TNFα and MIP1β. Cellular metabolism is now recognized to regulate functional properties of immune cells such as T or NK cells. The mammalian target of rapamycin (mTOR) kinase is a key regulator of cellular metabolism, integrating environmental cues to control downstream metabolic pathways. mTOR is the catalytic subunit of two different complexes: mTORC1 and mTORC2, the activity of which can be measured by measuring the level of phosphorylation of the proteins S6 and Akt respectively. The lab has previously shown that the mTOR pathway regulates NK cell development and activation 2. The investigators have observed that pS6 and pAkt are also decreased in CHB patients.
PROBLEM TO BE SOLVED: To quickly take out data at the time of medical examination even when huge data such as image data is preserved by using a storage device having a slow access speed, in a hospital system which the management of information within the hospital is performed by a computer. SOLUTION: Huge data is supplied to a server 4 and is stored in a high speed storage device 5 by an HDD, etc. Based on the reservation information on the patient registered in a device 3, huge data which is not scheduled to be accessed in a few days is moved from the device 5 to a low speed storage device 6 by an MO (magneto-optical disk) changer, etc., in the server 4. The data which is scheduled to be accessed in a few days out of the huge data stored in the device 6 is moved to the device 5 in the server 4. In the operation of this system, these movings are periodically performed. Because only huge data which is scheduled to be accessed in a few days is stored in the high speed storage device 5, the huge data can be quickly taken out at the time of medical examination and the medical examination efficiency is improved.
FIELD: biotechnology, veterinary mycology. SUBSTANCE: vaccine has a mixture of antigens from fungus culture Trichophyton equinium, strain N L 2251/70 and strain Microsporum canis VIEB N 473 taken at equal ratio and protective drying medium based on gelatin and sucrose. Concentration of each strain is 1×10 7 - 8×10 7  microconidia/1 ml. Vaccine is prepared by conventional method. Vaccine is used as prophylaxis and curative agent for control over trichophytosis and microsporia in horses by intramuscular injection, two doses at interval for 10-14 days. Vaccine provides the expressing and lasting immunity in horses. EFFECT: enhanced effectiveness of vaccine.
A retrospective chart review of 100 infants with Trisomy 21 and CAVC operated at CHOA at Egleston between January 1, 2001 and March 24, 2006 will be performed. Graphs of birth weight and rate of weight gain over time will be plotted for each patient and for the group as a whole. The point of reaching a plateau of weight gain will be decided for each patient and indexed for birth weight. Medical management will be detailed, i.e. all medications and all dietary information (caloric density of formula, route of administration). This medical management will be indexed as a function on the weight gain chart. Medical complications (such as respiratory infections, gastroenteritis, hospitalizations, and additional non-cardiac medications) will likewise be plotted and segmented according to position relative to the weight gain plateau. Age at eventual surgery and whether surgical date was delayed by complications will be noted. Surgical cardiopulmonary bypass time and morbidity and mortality will be noted. Postoperative length of ventilator support, length of stay in the CICU and total length of stay will be determined and also displayed as a function of body weight and as a function of time at plateau weight. Postoperative morbidity and mortality for the three months after repair will be noted, including all cause hospital re-admissions and outpatient medical complications (such as respiratory infections, gastroenteritis, and the need for continued medications for CHF).
A vaporizing device has a first housing removably attached to a second housing. A battery in the first housing is electrically connected to a control circuit. An LED is in the first housing. At least one air inlet allows air into the second housing. A wire coil heating element is inside of the second housing, with the wire coil heating element in physical contact with a ceramic component. The wire coil heating element is electrically connectable to the battery. The second housing has a liquid storage container containing a liquid. The wire coil heating element is co-axial with an outside surface of the ceramic component. Liquid from the liquid storage container contacts the ceramic component and the wire coil heating element provides heat for vaporizing the liquid.
The invention relates to 3 hybridoma cell lines, namely BE-8 (C.N.C.M. No. I/913), BE-4 (C.N.C.M. No. I/911) and BF-6 (C.N.C.M. No. I/912), which can be obtained by fusing immunised mouse spleen cells with mouse myeloma cells after the spleen cells have been immunised against interleukin-6 before the fusion. These 3 cell lines produce monoclonal antibodies which recognise human interleukin-6 and bind in each case to a different epitope, depending on the different cell lines, on the interleukin-6 molecule. The monoclonal antibodies can be coupled to toxins and/or chemotherapeutic agents and can be used for the preparation of a composition for the therapy, prophylaxis and diagnosis of interleukin-6-dependent disorders.
The aim is to explore the clinical effects of combined treatment of Traditional Chinese Medicine (TCM) and western medicine in viral hepatitis B cirrhosis and the effects on microRNA (miR)-122 and miR-200a. 116 patients with chronic hepatitis B cirrhosis were admitted to our hospital. Real-time fluorescent quantitative PCR (qPCR) was employed to reveal the level of serum miR-122 and miR-200a in the three groups. The clinical effects of the two groups were compared, including alanine aminotransferase (ALT), aspartate amino transferase (AST), total bilirubin (TBIL) and alpha fetoprotein (AFP) indexes, coagulation function indexes, liver elasticity value and the main therapeutic effects. After treatment, the ALT, AST, TBIL and AFP indexes significantly decreased in both groups, which were much lower in the western medicine (WM) + TCM Group. The levels of albumin (ALB) all increased, and the increase was more significant in the WM + TCM Group. The prothrombin time (PT) was down-regulated while the prothrombin activity (PTA) was up-regulated in both groups. Both groups showed a decrease in liver elasticity after treatment, which was more obvious in the WM + TCM Group. The incidence of primary peritonitis, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding and electrolyte disturbance in the WM + TCM Group was significantly lower than those in the WM Group. The combination of Chinese and western medicine in the treatment of cirrhosis can reduce the occurrence of complications, improve the clinical symptoms and improve the clinical effects effectively, which is worthy of further study and clinical popularization. Viral hepatitis B, Liver cirrhosis, Combination of TCM and Western medicine, miR-122, miR-200a.
BACKGROUND Coronavirus disease (COVID-19) can cause various complications. We report a case of severe COVID-19 acute respiratory distress syndrome (ARDS) in a patient receiving veno-venous extracorporeal membrane oxygenation (V-V ECMO), complicated by Guillain-Barre syndrome (GBS) and cerebral infarction, as well as pulmonary embolism. CASE REPORT A 55-year-old Japanese man with a history of ulcerative colitis was admitted for COVID-19. His respiratory status worsened and progressed to ARDS, requiring intubation on hospital day (HD) 3. On HD 16, contrast computed tomography revealed PE. On HD 18, his respiratory condition worsened, and V-V ECMO was initiated. On HD 23, V-V ECMO was successfully discontinued. He regained consciousness on HD 44, but he had quadriplegia. Deep-tendon reflexes were absent in all limbs. Cranial nerve involvement, specifically bilateral facial nerve weakness, was noted. Magnetic resonance imaging showed bilateral scattered cerebral infarctions on HD 76. Nerve conduction studies indicated severe axonal neuropathy. Cerebrospinal fluid examination showed albuminocytologic dissociation. The antibody to the ganglioside GD1a was positive. These findings were consistent with the diagnosis of GBS. He received immunoglobulin treatment on HD 89, and his neurological findings slightly improved. CONCLUSIONS This study emphasized that in COVID-19, neurological complications are not rare, are difficult to diagnose, and are prone to delays in detection.
Pulmonary contusion (PC), defined as damage to the lung parenchyma with edema and hemorrhage, has classically been associated with acceleration-deceleration injuries. It is a frequent pathology in clinical practice. However, its clinical presentation and imaging findings are nonspecific. Patients with this entity can present with findings that can range from mild dyspnea to life-threatening respiratory failure and hemodynamic instability. We present the case of a 61-year-old man, a former smoker, who presented to the emergency department after suffering blunt chest trauma. On admission, he complained of only mild shortness of breath, and his vital signs were typical. Initial imaging identified asymmetric pulmonary infiltrates and mediastinal lymphadenopathy; this was suspicious for additional pathology in addition to PC. After an exhaustive evaluation, a neoplastic or infectious disease process was ruled out. Even though the patient presented with a clinical deterioration of respiratory function compatible with secondary acute respiratory distress syndrome, there was a complete recovery after supportive measures and supplemental oxygen. In conclusion, the nonspecific clinical and imaging findings in patients with pulmonary contusion warrant a complete evaluation of these cases. An early diagnosis is essential to establish adequate support and monitoring to prevent possible complications that could worsen the patient's prognosis.