anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Brown adipose tissue (BAT) plays a critical role in regulating cardiovascular homeostasis through the secretion of adipokines, such as fibroblast growth factor 21 (FGF21). Dexmedetomidine (DEX) is a selective α2-adrenergic receptor agonist with a protection against myocardial ischemia/reperfusion injury (MI/RI). It remains largely unknown whether or not BAT-derived FGF21 is involved in DEX-induced cardioprotection in the context of MI/RI. Herein, we demonstrated that DEX alleviated MI/RI and improved heart function through promoting the release of FGF21 from interscapular BAT (iBAT). Surgical iBAT depletion or supplementation with a FGF21 neutralizing antibody attenuated the beneficial effects of DEX. AMPK/PGC1α signaling-induced fibroblast growth factor 21 (FGF21) release in brown adipocytes is required for DEX-mediated cardioprotection since blockade of the AMPK/PGC1α axis weakened the salutary effects of DEX. Co-culture experiments showed that DEX-induced FGF21 from brown adipocytes increased the resistance of cardiomyocytes to hypoxia/reoxygenation (H/R) injury via modulating the Keap1/Nrf2 pathway. Our results provided robust evidence that the BAT-cardiomyocyte interaction is required for DEX cardioprotection, and revealed an endocrine role of BAT in DEX-mediating protection of hearts against MIRI.
Home visits will be conducted at 2-3 and 6-8 weeks post-delivery. No intervention will be administered.
PURPOSE: To provide a compd. which is useful as an intermediate for synthesis of 26,26,26,27,27,27-hexafluoro-1α-25-dihydroxychloesterol.  
     CONSTITUTION: The compd. of formula I (R is H, an acyl, etc.; X is OH, an O-acyl, O-trityl, etc.). For example, 25,26,27-trinor-1α,3β-diacetoxycholest-5-en-24- ylphenyl sulfone is provided. The compd. of the formula I is obtd. by converting a commercially marketed cholenic acid to an ester, oxidizing the same with dichlorodicyanaobenzoquinone to obtain a trienone, processing the same with an alkaline hydrogen peroxide to obtain a 1,2-epoxide, reducing this epoxide with metal lithium and ammonium chloride in liquid ammonia-THF, to obtain a compd. of formula II, further subjecting the compd. to acetylation and hydrolysis to obtain a compd. of formula III, further converting the compd. to compds. of formula IV, formula V, hydrolyzing these compds. to form a compd. of formula VI, then bringing the compd. into reaction with triethylchlorosilane to obtain a compd. of formula VII and further to obtain a reacted compd. of formula VIII. 
     COPYRIGHT: (C)1993,JPO
The invention belongs to the technical fields of biological medicine and molecular biology, and particularly relates to application of SMEK1 in diagnosis and treatment of ischemic cerebral apoplexy. The invention reports that SMEK1 presents fluctuation change after ischemic cerebral apoplexy for the first time and presents descending trend in a quite long time. The decrease in microglial SMEK1 causes it to secrete more pro-inflammatory factors, polarizing microglial cells in the M1 direction. The SMEK1 overexpression has proved to have the effect of improving the nerve injury after the cerebral arterial thrombosis of mice. In addition, the research of the invention finds that SMEK1 can regulate the polarization direction of microglial cells through mitochondrial metabolism reprogramming, and can reduce inflammatory response after ischemic cerebral apoplexy by promoting the expression of the SMEK 1. In a word, the invention provides a new mechanism research for the occurrence and development of ischemic cerebral apoplexy and provides a promising treatment strategy for ischemic cerebral apoplexy patients, thus having good practical application value.
PROBLEM TO BE SOLVED: To obtain a perfume incense stick capable of radiating faint fragrance in a room when burning the perfume incense stick by dispersing a base perfume, perfume components comprising a powder of Santalum album, vanillin and Kaiko (powdered operculum of the rock shell), and other functional components in a binding base material. SOLUTION: This perfume incense stick is obtained by dispersing (A) 3-10 wt.%, preferably 5-8 wt.%, more preferably 5-7 wt.% perfume components consisting essentially of (i) a base perfume, (ii) a powder of Santalum album, (iii) vanillin and (iv) Kaiko, and (B) other functional components in (C) a binding base material (a matrix). The formulating proportion of the components (i) to (iv) is preferably 30-500 pts.wt. component (ii), 3-50 pts.wt. component (iii) and 0.1-1 pts.wt. component (iv) based on 100 pts.wt. component (i). The one obtained by properly adding a synthetic paste such as a polyvinyl alcohol, or a natural or semisynthetic paste such as starch and CMC to a powder of a tree or bark, or the like is used as the component C.
Cohort 1 and 2 youth will then complete baseline assessments (see 4.5) and Cohort 2 will continue receiving TAU while Cohort 1 begins receiving DBT-A (randomized by facility to either in-person or via telehealth delivery) for the next six months while Cohort 1 staff continue consultation with DBT-A. After six months, Phase 2 of this study will conclude with the youth of Cohorts 1 and 2 completing their first follow-up assessment. The implementation plan will be altered accordingly based on feedback from stakeholders prior to the start of Phase 2. The modified implementation plan will be used in the training of the staff in DBT-A at the second four facilities prior to the launch of Phase 3.
Patients receive gallium Ga 68-labeled PSMA-11 IV and undergo a PET/CT scan over 30 minutes. On a separate day, patients receive fluciclovine F18 IV and undergo a PET/CT scan over 30 minutes.
All study subjects were provided with a unique identifier. The ones that ended in an even number were administered the CP1110 Sound Processor followed by the CP1000 Sound Processor.
PROBLEM TO BE SOLVED: To obtain the subject preparation for external use improved in stability and further slowness of a phase inversion change by including a polyhydroxy stearic acid ester of a polyhydric alochol. SOLUTION: This skin preparation for external use is obtained by including preferably 0.1-10 wt.% of a poly(12-hydroxystearic acid) ester of a polyhydric alcohol, e.g. polyethylene glycol-α,α-bis(poly(12-hydroxystearic acid)) ester. Both of a solubilized system and an emulsified system can be used as the dosage form of the above skin preparation for external use. A multiphase emulsion form is especially preferred and an O/W/O emulsion form is especially preferred. In the above preparation for external use, an optional ingredient, especially preferably 0.1-1 wt.% of a nonionic surfactant having a low HLB (e.g. a sucrose ester of a fatty acid) is contained besides the above essential ingredients.
A human protein molecule termed H13 has strong sequence homology to murine retrovirus receptor proteins and encodes a human retrovirus receptor. DNA encoding the H13 protein, cells transformed and transfected with this DNA and antibodies specific for H13 are disclosed. The H13 protein or its functional derivative can be used for preventing or treating retrovirus infection by administration to a subject of the H13 protein or a functional derivative thereof, or an anti-H13 antibody. Transgenic animals, useful as animal models for diagnosis or therapy of human retrovirus infections, are made by transfecting embryonic cells with the H13-encoding DNA. A chimeric retrovirus receptor protein comprises the H13 sequence, having substituted therein, amino acid residues encoding a murine retroviral receptor. Expression of the chimeric receptor in human cells allows infection or retrovirus-mediated gene transfer with murine retroviruses, which provides an extra measure of safety for in vivo gene therapy. DNA encoding the chimeric retrovirus receptor protein, cells transformed with this DNA, and methods for rendering a cell susceptible to infection by a retrovirus normally incapable of infecting that cell are disclosed.
The invention relates to a plaster for curing neck, shoulder, waist and leg pain and a preparation method, belonging to the technical field of Chinese medicine. The raw materials of the plaster with a certain quantity by proportion are as follows: musk, common monkshood mother root, kusnezoff monkshood root, ephedra herb, manchurian wildginger, notopterygium root, dahurian angelica root, cinnamon, dried ginger, frankincense, borneol, himalayan teasel root, myrrh, yellow lead, and strychnic; wherein, musk, frankincense, myrrh and borneol are milled to fine powders; and then the fine powders are sieved and mixed evenly. The rest raw materials are crushed into coarse materials. The coarse materials except yellow lead and benne oil are put into a pot for soaking for 3 to 7 days; and then the mixture is decocted until the drip can form a bead. The medical oil is added with the crushed yellow lead for mixing. The oil plaster is dropped into water until the oil plaster forms into conglomeration and has no viscosity; and then the fine materials are added for mixing evenly so as to obtain the plaster. The plaster is finally poured into a cold water cylinder so as to clear heat. The invention has the advantages of nontoxic and no side effect, having a curing rate of 80 percent, an effective rate of 95.7 percent and ineffective rate of 4.7 percent for herniation of cervical disc and shoulder and leg pain, and obviously decreasing the recrudescence rate.
OBJECTIVES: Fatigue can be the result of overexertion and overload. It occurs when the burdened body does not have enough time for regeneration and biological renewal. The aim of this study was analysis of fatigue based on the subjective feeling in physiotherapists, nurses, and paramedics.
MATERIAL AND METHODS: The research covered 193 women and 107 men aged 30-60 years, including 100 physiotherapists, 100 nurses and 100 paramedics with higher education, employed in clinics and hospitals in the Podkarpackie Voivodeship, Poland. The research tool of choice was 30-item Research Committee on Industrial Fatigue Fatigue Scale, adapted into the Polish language by Paluch. The data were analyzed based on ANOVA Kruskal-Wallis test, Mann-Whitney U test and Spearman's rank correlation.
RESULTS: Values determining frequency of decrease in activity were higher in nurses than in physiotherapists (p < 0.001) and paramedics (p = 0.005). Physiotherapists and nurses showed statistically significant positive associations of all fatigue indices with age and seniority. Sex-related differences in the frequency of physical fatigue symptoms have been noted (p = 0.044). Among people working in outpatient clinics and hospitals there were statistically significant differences in the frequency of decrease in activity (p = 0.001) and general level of fatigue (p = 0.031).
CONCLUSIONS: In nurses and physiotherapists, the frequency of experiencing ailments increases with age and work experience. This suggests that in the case of these professions it is important to quick identification of signs of fatigue and taking actions to prevent its worsening. Women experience fatigue more often, so they especially need to take steps to prevent and, if necessary, treat this condition. Hospitals should be an area of special involvement in the process of implementing programs to counteract fatigue of employees in the medical services sector. Int J Occup Med Environ Health. 2024;37(1):72-83.
Participants in this group had pathologically confirmed pancreatic adenocarcinoma. They received an EGD with EUS. During the EUS, blood flow was measured in the duodenum with the 4D-ELF device.
<P>PROBLEM TO BE SOLVED: To provide a product for preventing damage of biological deep tissue caused by a near-infrared ray using an agent for preventing damage of biological deep tissues caused by near-infrared rays which inhibits a near-infrared ray from reaching not only skin tissues but also deeper tissues than skin tissues, prevents the tissues from damage caused by near-infrared rays, prevents various diseases caused thereby from developing or progressing and also prevents aging.  <P>SOLUTION: The product for preventing damage of biological deep tissues includes a near-infrared ray transmission blocker including a metal-oxide powder doped by a metal. The blocker absorbs, reflects or scatters the near-infrared ray of 770-2,500 nm exposed to the living body, thus preventing tissues deeper than those of the skin from damage due to the near-infrared ray. The product has a member in which the blocker is coated, adsorbed, adhered or stuck onto at least a part of a substrate, or is contained therein. The product also includes a coating material contained in a medium.  <P>COPYRIGHT: (C)2010,JPO&INPIT
OBJECTIVE: The objective of this study was to investigate risk factors for new-onset atrial fibrillation (NOAF) post-percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI), aiming to develop a predictive nomogram for NOAF risk.
METHODS: A retrospective cohort study involving 397 AMI patients who underwent PCI at a tertiary hospital in Anhui, China, from January 2021 to July 2022 was performed. Patients were divided into NOAF (n = 63) and non-NOAF (n = 334) groups based on post-PCI outcomes. Clinical data were extracted from the hospital information system (HIS) and analyzed using univariate and multivariate logistic regression to identify independent risk factors. A nomogram was generated utilizing R software (version 3.6.1), with its performance evaluated through receiver operating characteristic (ROC) curves, calibration curves, decision curve analysis (DCA), and Bootstrap resampling.
RESULTS: Independent risk factors for NOAF included age, left atrial diameter (LAD), Gensini score, N-terminal pro-B-type natriuretic peptide (NT-proBNP), alanine transaminase (ALT), low-density lipoprotein cholesterol (LDL-C), left ventricular end-systolic diameter (LVESD), and ventricular rate (P < 0.05). The nomogram's ROC curve demonstrated an area under the curve (AUC) of 0.925 (95% CI: 0.887-0.963), supported by a Bootstrap-verified AUC of 0.924 (95% CI: 0.883-0.954), reflecting strong discriminative capability. The calibration curve indicated a mean absolute error (MAE) of 0.031 and 0.017 prior to and following Bootstrap verification, respectively, signifying robust calibration. The DCA curve illustrated that the nomogram offered optimal clinical net benefit for patients with a threshold probability of NOAF ranging from 0.01 to 0.99.
CONCLUSION: The nomogram developed from independent risk factors for NOAF exhibits significant predictive accuracy and clinical relevance for evaluating the risk of NOAF in AMI patients following PCI, thereby enabling the identification of high-risk individuals for targeted interventions.
Among the various functions impaired by aging there is the muscle function, which indirectly affects the quality of life for seniors, since it is crucial to the progressive increase of the debilitating condition, leading to difficulties in carrying out everyday tasks and often making them dependent on the assistance of others. The possible neural mechanisms underlying this decrease in muscle function associated with aging include changes undefined in Central Nervous System, a delay in conduction velocity of motor nerve fibers and in transmission of the neuromuscular junction. In this context, it is necessary to develop procedures that reduce the functional losses and decrease the negative effects of the aging process, increasing the quality of life for seniors. Mirror Therapy (MT) is the one of those possible procedures, which is based on the activation of mirror neurons from the illusion generated by viewing the reflection of a member in a mirror. When performing a movement with a member who is in your field of vision, generated the reflection in the mirror is able to offer the brain a new, albeit illusory visual stimulus, suggesting that covert member is moving. This illusion promotes the activation of mirror neurons located in the sensorimotor cortex region and the progression of therapy, this activation drives cortical plasticity that promotes the reestablishment of functions, such as motor coordination and increased range of motion. Therefore, MT is a promising technique to reduce the functional losses of aging. It is then suggested the implementation of a protocol for functional recovery of MT hands in institutionalized elderly and the measurement of electromyographic activity of the wrist, the range and speed of movement, the writing skill and the application of a questionnaire to Katz index calculation in order to investigate whether the technique can benefit this public.
C:\NRPonbADCC\DAE63756249_].PDC-]4/7/20i1. A topical formulation comprising as active ingredients, at least one effective agent derived 5 from Streptomyces avermitilis, Le. a macrocylic lactone e.g. an avermectin or chemically modified or synthetic derivative thereof, e.g. iverinectin, together with another anthelmintic of the sulphonamide type, e.g. clorsulon, in a carrier that facilitates topical administration and delivery of the active ingredients transdermal Iy, e.g. a carrier that is useful for this purpose comprises alcoholic solvents, such as ethanol, and isopropanol, with 10 optional excipients and formulation aids, which may comprise a polymeric species such as PVP or a poloxamer.
Atrial fibrillation (AF) is the most common arrhythmia and its incidence increases with sepsis. However, data on new-onset AF during sepsis hospitalization remain limited in China. We aimed to evaluate the incidence, risk factors, and associated mortality of new-onset AF in sepsis patients in China. We conducted a retrospective study using the National Data Center for Medical Service system, from 1923 tertiary and 2363 secondary hospitals from 31 provinces in China from 2017 to 2019.In total we included 1,425,055 sepsis patients ≥ 18 years without prior AF. The incidence of new-onset AF was 1.49%. Older age, male sex, hypertension, heart failure, coronary disease, valvular disease, and mechanical ventilation were independent risk factor. New-onset AF was associated with a slight increased risk of mortality (adjusted RR 1.03, 95% CI 1.01-1.06). Population attributable fraction suggested AF accounted for 0.2% of sepsis deaths. In this large nationwide cohort, new-onset AF occurred in 1.49% of sepsis admissions and was associated with a small mortality increase. Further research should examine whether optimized AF management can improve sepsis outcomes in China.
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder characterized by relentless and progressive loss of motor neurons. A molecular diagnosis, supported by the identification of specific biomarkers, might promote the definition of multiple biological subtypes of ALS, improving patient stratification and providing prognostic information. Here, we investigated the levels of neurofilament light chain (NfL), chitotriosidase (CHIT1) and microRNA-181b (miR-181b) in the cerebrospinal fluid (CSF) of ALS subjects (N = 210) as well as neurologically healthy and neurological disease controls (N = 218, including N = 74 with other neurodegenerative diseases) from a large European multicentric cohort, evaluating their specific or combined utility as diagnostic and prognostic biomarkers. NfL, CHIT1 and miR-181b all showed significantly higher levels in ALS subjects compared to controls, with NfL showing the most effective diagnostic performance. Importantly, all three biomarkers were increased compared to neurodegenerative disease controls and, specifically, to patients with Alzheimer's disease (AD; N = 44), with NfL and CHIT1 being also higher in ALS than in alpha-synucleinopathies (N = 22). Notably, ALS patients displayed increased CHIT1 levels despite having, compared to controls, a higher prevalence of a polymorphism lowering CHIT1 expression. While no relationship was found between CSF miR-181b and clinical measures in ALS (disease duration, functional disability, and disease progression rate), CSF NfL was the best independent predictor of disease progression and survival. This study deepens our knowledge of ALS biomarkers, highlighting the relative specificity of CHIT1 for ALS among neurodegenerative diseases and appraising the potential diagnostic utility of CSF miR-181b.
The etiology of spina bifida, a neural tube birth defect, is largely unknown, but a majority of cases are thought to be genetic in origin. Although maternal blood type was found not to be associated with the occurrence of spina bifida, the analysis was never extended to other aspects of the disorder. The purpose of this descriptive study was to determine if maternal blood type was related to characteristics of children with spina bifida. The blood type of 221 mothers of children with spina bifida enrolled on the Arkansas Spinal Cord Disability Registry from 1995 to 2008 was obtained by mailed questionnaire. All children were community-dwelling and from singleton pregnancies. As expected, analysis of mother-child data showed that the distribution of mothers' blood type was not statistically different from the general population (chi-squared, P = 0.9203). However, the blood type of these mothers was associated with their child's lesion level (chi-squared, P = 0.011). Mothers with blood type A more frequently had children with thoracic lesions; mothers with non-A blood types more frequently had children with lumbar and sacral lesions. In addition, mean birthweight differed by mothers' blood type (analysis of variance, P = 0.025). Children of mothers with blood type A had the highest mean birthweight, while those of mothers with blood type AB had the lowest. Also, hydrocephalus was present more frequently in children with thoracic lesions compared to those with lumbar and sacral lesions (chi-squared, P = 0.001). Interestingly, these results were significant for female children but not for male children. In conclusion, maternal blood type was associated with lesion level and birthweight of children with spina bifida.