anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a vinpocetine injection and a preparation method thereof. The vinpocetine injection comprises 10 to 20 parts of vinpocetine, 7 to 15 parts of tartaric acid and 2000 parts of water. The preparation method of the vinpocetine injection comprises the following steps of 1, taking 80% of water for injection, carrying out filtration deoxygenation, heating to a temperature of 40 to 50 DEG C, adding tartaric acid into the heated water for injection, and stirring until complete dissolution, 2, adding vinpocetine into the solution obtained by the step 1, stirring until complete dissolution, supplying enough water for injection to the mixed solution, and carrying out stirring adsorption by 0.3% of active carbon, and 3, carrying out sterilization at a temperature of 121 DEG C for 15 minutes and carrying out nitrogen-filling loading. Utilization of tartaric acid in the components of the vinpocetine injection is conducive to dissolution of alkaline vinpocetine and can effectively inhibit the production of insoluble particles. A contrast experiment proves that through the preparation method, drug composition stability is improved. The production of insoluble particles shows that products are unstable due to prolonging of a storage period. The vinpocetine injection adopting tartaric acid as a cosolvent is stable and can produce a small amount of insoluble particles in a long time and thus the safety of the vinpocetine injection in use is ensured.
Use of CLOBEX Lotion, 0.05% in pediatric patients is not recommended due to the potential for HPA axis suppression [see Warnings and Precautions (5.1)].  
  
The HPA axis suppression potential of CLOBEX Lotion, 0.05% has been studied in adolescents (12 to 17 years of age) with moderate to severe atopic dermatitis covering a minimum of 20% of the total body surface area. In total 14 subjects were evaluated for HPA axis function. Subjects were treated twice daily for 2 weeks with CLOBEX Lotion, 0.05%. After 2 weeks of treatment, 9 out of 14 of the subjects experienced adrenal suppression. One out of 4 subjects treated with CLOBEX Lotion, 0.05% who were retested remained suppressed two weeks post-treatment. In comparison, 2 of 10 subjects treated with clobetasol propionate cream, 0.05% demonstrated HPA axis suppression. One subject who was retested recovered.   
  
None of the subjects who developed HPA axis suppression had concomitant clinical signs of adrenal suppression and none of them was discontinued from the study for reasons related to the safety or tolerability of CLOBEX Lotion, 0.05%. However patients with acute illness or injury may have increased morbidity and mortality with intermittent HPA axis suppression.  
  
Because of higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression and Cushing’s syndrome when they are treated with topical corticosteroids. They are therefore also at greater risk of glucocorticosteroid insufficiency during and/or after withdrawal of treatment. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children.  
  
HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma cortisol levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.
BACKGROUND AND AIMS: Acute hepatitis E (AHE) is still a public health issue worldwide. Here, we report the global burden of AHE in 204 countries and territories from 1990 to 2019 by age, sex and socio-demographic index (SDI), and predict the future trends to 2030.
METHODS: Data on AHE were collected from the Global Burden of Diseases, Injuries and Risk Factors Study 2019. The average annual percentage change (AAPC) and joinpoint analysis were used to determine the burden trend.
RESULTS: In 2019, there were 19.47 million (95% UI, 16.04 to 23.37 million) incident cases of AHE globally, with a 19% increase since 1990. Age-standardized rate (ASR) of disability-adjusted life years (DALYs), prevalent and incident cases declined from 1990 to 2019. In 2019, the ASR of incidence, prevalence and DALYs due to HEV infection were highest in the same regions of South Asia for both sexes. Southern Sub-Saharan Africa presented the highest increases in the ASR for incidence of HEV infection in both males (AAPC = .25) and females (AAPC = .24) from 1990 to 2019. Incident cases are higher in males than females before 55-59 years old. The SDI values were negatively correlated with the age-standardized DALYs. Between 2019 and 2030, the ASR for incidence and prevalence of HEV for both sexes showed an increasing trend.
CONCLUSIONS: Although the overall ASR of AHE decreased, the burden of AHE remains an underappreciated problem for society. The findings may provide useful information for policymakers to develop appropriate strategies aimed at reducing the burden of AHE.
OBJECTIVE: Recurrent cerebrospinal fluid (CSF) rhinorrhea caused by sequential, anatomically separated skull base defects is rarely reported in the literature. Neither management nor etiology has been sufficiently investigated. We present an illustrative case and a systematic review of the literature regarding etiology, diagnostics, and management of this rare phenomenon.
METHODS: A systematic literature search looking for articles reporting sequential CSF leaks with multiple skull base defects was performed. Data from included articles were descriptively reported, and the quality of the included studies was assessed with Grading of Recommendations Assessment, Development and Evaluation.
RESULTS: A 71-year-old woman with posttraumatic CSF rhinorrhea and left-sided CSF otorrhea due to a left-sided horizontal fracture of the petrous bone presented at our institution. After initial surgical repair and a 10-week symptom-free interval, CSF rhinorrhea recurred. Imaging revealed a preexisting contralateral meningoencephalocele of the lateral sphenoid recess causing recurrent CSF rhinorrhea most likely after initial traumatic laceration. The defect was successfully treated. A literature search identified 366 reports, 6 of which were included in the systematic review with a total of 10 cases. Quality was deemed good in 8 of 10 cases. The most common location for primary and sequential CSF leaks was along the sphenoid bone (4/10 and 5/10 patients, respectively). All publications except one reported the presence of a meningo (encephalo)cele as cause of the sequential CSF leak.
CONCLUSIONS: Occurrence of recurrent CSF rhinorrhea due to an anatomically separated sequential skull base lesion remains a rare phenomenon. Reassessment of imaging studies and a structured diagnostic workup to detect sequential CSF leaks independent of the primary lesion should is recommended.
Lunaphil Ultra (by Espad Pharmed Co.) will be administered over a 2-week period (initial treatment plus one touch-up) to achieve optimal correction of the NLFs. In case of suboptimal correction of NLFs at week 2 after the initial treatment, the treating investigator will be directed to retreat the under corrected NLF(s).
This study proposes to examine a novel application of a cognitive bias modification (CBM) intervention designed to target stigma-related cognitions among service members at elevated suicide risk not currently engaged in behavioral health treatment. Interventions that leverage CBM principles involve the completion of brief, web-based tasks in which participants are presented with a series of stimuli (e.g., words, sentences) and trained to respond to those stimuli in a manner that is positive or neutral, rather than negative and unhelpful. Consistent with the theoretical rationale for Cognitive Behavioral Therapy, CBM interventions function by reshaping negative cognitions. Repeated reinforcement of adaptive cognitions enhances functioning and reduces distress. CBM interventions have efficacy in reducing maladaptive cognitions across a range of psychiatric symptoms. However, limited data exist regarding the use of CBM to target help-seeking stigma cognitions.
During the past decade, museums have become involved in the care of patients by using art to improve their quality of life and well-being. Museums have, thus, emerged as new partners in public health. Very few programs developed by museums have focused on primary care patients who are a target audience for museum health program preventions. For the development of appropriate museum programs based on visit tour, there is a need to improve knowledge the effects of a museum visit prescribed by a primary care physician in patients. The objective of this study is to examine effects on mental and physical health and quality of life in primary care patients visiting the Montreal Museum of Fine Arts (MMFA), this visit being prescribed by their physician. Based on a cross-sectional study it will be prescribed to all patients consulting their primary care physician to visit the MMFA and to complete after this visit a series of self-administered questionnaires within the two days after their visit at the museum. The period of recruitment will be one year. The outcomes are the scores of the different questionnaires.
This study presents a lightweight, secure audio steganography system for hiding text messages for transmission over the Internet, with the aim of addressing the current problems of high computational cost and insufficient security identified in earlier studies. We propose a two-phase functioning mechanism. Text characters are first transformed into ASCII code and stored in a vector, which is then divided into three sub-vectors. These sub-vectors are scrambled using two low-complexity operations, namely a forward-backward reading technique and an odd-even index. Two scrambling loops are performed, the first on the small sub-vectors the second on the vector as a whole. In the hiding phase, the speech signal samples are divided into 256 blocks using only 200 values per block, and low-complexity quadratic and the Hénon maps are used to hide the speech signal in a random manner. The conditional LSB is applied as a low-complexity algorithm to identify hidden bits, and a special hyperchaotic map algorithm is developed to randomly choose locations. The proposed approach provides good security for a scrambled text message, with high SNR and PSNR, small MSE and PESQ, a SSIM value of close to one (As indicated in Tables 1, 2, 3, and 4), a BER value of close to zero (as shown in table 8), NCC value near +1 (as shown in table 8), and an MOS value of near five (as described in table 6), as well as a low computational hiding cost.
UNLABELLED: The incidence of diabetic retinopathy (DR) requiring vitreorentinal surgery is increasing. The search for new effective and safe methods of treatment, the choice of the optimal time for surgery, and the assessment of long-term treatment outcomes are relevant problems.
PURPOSE: This study evaluates the long-term results of vitreorentinal surgery using the bimanual technique in DR with different stages of fibrovascular proliferation.
MATERIAL AND METHODS: The study included 135 patients (135 eyes) who were divided into groups depending on the predominant type of proliferation - vascular or fibrous. Patients underwent vitrectomy with membranectomy using the bimanual technique, with peripheral panretinal endolaser coagulation of the retina and tamponade of the vitreous cavity with balanced salt solution. The postoperative observation period lasted up to 12 months.
RESULTS: Both groups showed statistically significant improvement in visual function and anatomical changes in central retinal thickness. A statistically significant improvement in best corrected visual acuity (BCVA) was found in patients with initially predominantly vascular proliferation. Correlation analysis showed that initially higher BCVA tends to persist in the postoperative period. A negative correlation was found between the final BCVA and the presence of type 2 diabetes mellitus, fibrous stage of proliferation, high central retinal thickness, and the presence of diabetic macular edema (DME) - both initially and after treatment. The frequency of complications in the groups was comparable, except for postoperative DME, which was more often detected in patients with fibrous proliferation.
CONCLUSION: The bimanual technique of vitreorentinal surgery for complications of DR allows achieving high anatomical and functional results. Higher BCVA is noted in patients with the vascular stage of proliferation and initially high BCVA. The obtained data allow us to form a hypothesis about the possibility of earlier surgery in patients with high BCVA, but require further investigation.
RA patients on stable treatment (\> 1 year) with other (non-MTX) DMARDs, with or without NSAIDs and/or steroids, and continued on the same treatment. The overall management, tests and outpatient rheumatology visits schedule will be similar to other patients with RA, in accordance to standard practice.
INTRODUCTION: Urinary incontinence (UI) is one of the most common chronic diseases among women, which can endanger their physical and mental health and incur a heavy financial burden on both individuals and society. Web-based interventions (WBIs) have been applied to manage women's UI, but their effectiveness has remained inconclusive. This systematic review and meta-analysis aims to explore the effectiveness of WBIs on self-reported symptom severity, condition-specific quality of life, adherence to pelvic floor muscle training (primary outcomes) and other extensive secondary outcomes among women with UI. We also aimed to investigate whether intervention characteristics (format, interactivity and main technology) have impacts on the effectiveness of primary outcomes.
METHODS AND ANALYSIS: This systematic review protocol was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. 10 electronic databases will be comprehensively searched from their inception to 1 May 2024, along with grey literature searches and manual reviews of relevant reference lists to identify eligible randomised controlled trials. The methodological quality of the included studies will be assessed by two reviewers based on the Cochrane Risk of Bias Tool. Meta-analyses will be conducted via Stata V.12.0. Leave-one-out sensitivity analyses will be performed, and publication bias will be evaluated using funnel plots and Egger's test. Subgroup analyses regarding intervention format, interactivity and main technology will be carried out.
ETHICS AND DISSEMINATION: No ethics approval is needed for this review since no primary data are to be collected. The results of this review will help develop an optimal WBI for women with UI, thereby providing them with maximum benefits. The findings will be disseminated via a peer-reviewed journal or conference presentation.
PROSPERO REGISTRATION NUMBER: CRD42023435047.
Patients will be chosen for the study based on presence of carotid artery stenosis ascertained by CTA and carotid artery ultrasound. Patients will receive and intravenous injection of the radiolabeled PET tracer,\[F-18\]RGD-K5, and will undergo PET imaging of their carotid arteries bilaterally. PET images will be analyzed to determine the standard uptake value (SUV) of \[F-18\]RGD-K5 uptake by the carotid artery plaque and this will be compared to the SUV of the background (blood pool in the aorta). This will be expressed as a target to background ratio (TBR). Investigators expect to find a significant uptake of \[F-18\]RGD-K5 by carotid artery palque and investigators therefore expect to find a TBR that is significantly \>1. Investigators also expect to find that plaque from patients who show a TBR \>1 will also be enriched for histologic markers for inflammation and angiogenesis.
The invention discloses a honeysuckle-containing composition. The composition is prepared from the following materials: 10-35 parts of honeysuckle, 10-25 parts of red flowers, 10-25 parts of China rose, 0.5-3 parts of yarrow essential oil and 0.5-3 parts of lemon essential oil. The invention also discloses an application of the composition in preparing the anti-bacterial, skincare and deodorizing drugs or household chemicals. The invention also discloses a shower gel containing the honeysuckle composition. The shower gel is prepared from the following components: 10-35 parts of honeysuckle, 10-25 parts of red flowers, 10-25 parts of China rose, 0.5-3 parts of yarrow essential oil, 0.5-3 parts of lemon essential oil, 0.3-1 part of surface active agent, 0.3-1 part of wetting agent and a defined amount of citric acid. The shower gel disclosed by the invention is natural and safe, is capable of sterilizing and relieving itching, is non-irritant to skin, has the functions of activating skin, brightening skin, moisturizing and remaining fragrance and has a certain regulating function for physical health, such as irregular menstruation of women.
PURPOSE: An osteoblast differentiation promoting agent, a pharmaceutical composition, and health functional food for promoting osteogenesis containing coumarin compounds are provided to ensure high stability, and to promote differentiation of osteoblast. CONSTITUTION: An osteoblast differentiation promoting agent contains purified auraptene denoted by chemical formula 1 or an analog thereof, and a coumarin compound. A pharmaceutical composition for promoting osteoporosis contains the osteoblast differentiation promoting agent as an active ingredient. A food additive contains the osteoblast differentiation promoting agent. Food contains the food additive. Health functional food contains the osteoblast differentiation promoting agent.
The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.
PURPOSE: A method for enhancing sensitivity of cancer cells with respect to radiation by underexpression of dicckopf-1(DKK1) gene is provided to maximize cancer call apoptosis and to enhance anticancer therapeutic effect. CONSTITUTION: A radiation sensitizer for treating cancer contains an agent for suppressing expression or activation of Dickkopf-1(DKK1) protein having an amino acid of sequence number 1. The cancer is a cancer caused by DKK1 gene overexpression. The cancer is lung cancer. The agent for suppressing DKK1 protein expression is antisense nucleotide or small interfering RNA. The agent for suppressing DKK1 protein activation is a compound, peptide, peptide mimetic, or antibody which complementarily binds to DKK1 protein. The radiation is gamma radiation.
NEW MATERIAL:A compound (difurocumenon) expressed by the formula having the following physicochemical properties: Appearance, odorless and colorless crystal; melting point, 151-153 deg.C; high resolution mass spectrum analysis, m/z: 4442690; molecular formula. C30H36O3; specific rotation, [alpha] =+27.3 deg. (C: 1.11, chloroform); solubility, readily soluble in pyridine, dimethylsulfoxide, chloroform, acetone and ethyl acetate, soluble in methanol, ethanol and hexane and insoluble in water. USE:Antiphlogistics. PREPARATION:Curucuma aeruginosa Roxb. is extracted with an organic solvent and the extracted liquid is concentrated to afford extract, which is chromatographed using a column chromatography and high speed liquid chromatography and then subjected to fractional crystallization with an organic solvent.
The BARCODE 1 study aims to evaluate genetic profiling using the known \~170 prostate cancer (PrCa) risk single-nucleotide polymorphisms (SNPs) as a means of offering targeted screening for PrCa in men at a genetically higher risk. Initially, 300 men were recruited via participating General Practices (GPs). The full study aimed to recruit an additional 4700 participants. Men aged 55-69 years who were likely to be eligible for the study were identified by GPs from medical records. Participants were contacted via invitation letters from GPs and if interested in the study were asked to sign a consent form and complete a questionnaire to confirm eligibility to participate. If eligible, men were then sent a DNA collection saliva kit. DNA from saliva was analysed with SNP profiling for the known \~170 clinically relevant SNPs. Men with a genetic risk equivalent to the top 10% of the population distribution (approximately 470 men in total from the full study) were invited for an MRI and a transperineal (TP) prostate biopsy under local anaesthetic (LA), plus further biological samples. Biopsy results will be correlated with the genetic score. The study also aims to determine the incidence and aggressiveness of prostate cancer in men within the top 10% of the genetic score. Furthermore, the association of MRI appearance and biological sample biomarker profile with prostate biopsy result in men at genetically higher prostate cancer risk undergoing targeted screening will also be determined.
The treatment consisted of 5 sessions, all patients completed a recovery time after treatment of 30 min duration. The sessions were administered over a period of 5 weeks (one session per week). The acupuncture treatment was semi-standardised. It consisted of a basic pool of 6 body acupuncture points. Five additional acupuncture body points together with auricular points formed an individual pool. After needle insertion, the needle was manipulated until the subject obtained the de-Qi response (a deep aching or full feeling at the needle, \[22\]). After obtaining the de-Qi response, there was no further manipulation of the needle. Each session lasted 20 minutes.
PURPOSE:To improve the taste and flavor of a syrup without lowering the antiseptic effect of benzoic acid, by adding benzoic acid to a syrup containing D-sorbitol and adjusting the pH of the mixture by the addition of an organic acid salt. CONSTITUTION:Benzoic acid is dissolved in purified water under heating and the solution is mixed with a D-sorbitol solution and stirred to obtain a homogeneous solution. A drug is added to the solution after cooling and dissolved by stirring. An organic acid is added as a pH-modifier to the obtained solution to adjust the pH to 3.0-4.0 and the solution is added, as necessary, with a flavor and mixed with purified water to adjust the total amount and obtain the objective syrup having improved taste and flavor. The amount of the organic acid salt is 0.1-4pts.wt., preferably 0.2-2pts.wt. per 1pt.wt. of benzoic acid.
Participants receive mesenchymal stromal cells-derived exosomes with KrasG12D siRNA IV over 15-20 minutes on days 1, 4, and 10. Treatment repeats every 14 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. Participants who respond may continue 3 additional courses.