anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition for improving sexual function, which contains Nelumbinis semen extract is provided to enhance strength of erection. CONSTITUTION: A composition for improving sexual function contains Nelumbinis Semen extract as an active ingredient. The Nelumbinis Semen extract is extracted using water, alcohol or their mixture. The alcohol is a low alcohol of C1-C4, ethanol. The extract is obtained by extracting at 60-100 °C for 1-15 hours once to five times. A method for treating electile failure is to administer pharmaceutically effective amount of the extract to the patient.
The subjects continued their usual insulin regimen throughout the study. Metformin was started at 500 mg orally daily. The dose was increased over a 2 week period up to 2,000 mg per day as tolerated.
PROBLEM TO BE SOLVED: To release the medicines without being affected by the environment in the stomach and intestines such as the existence of food, the hydrogen ion concentration in the humor, or the like by injecting a medicines releasing mechanism such as a compact pump or the like and a tone decoder, and remote controlling the releasing of the medicines from the medicines releasing mechanism by the voice. SOLUTION: The voice is converted into an electric signal by using a microphone. A voice signal is input to a tone decoder. A medicines releasing mechanism such as an electric pump and a humor sampling mechanism are connected with a tone decoder driving part. The tone decoder can use an IC for monotone such as LM-567 and an IC for dual tone such as LC 7385. The power for releasing the medicines and sampling the humor can be accumulated in a battery, a pressure pump, a pressure reducing bomb and a spring. The operation for releasing the medicines and sampling the humor can be performed by a motor, a tube pump, a gear pump, a screw pump and a heater combined with the power.
The invention discloses a recomposing PAC1 receptor excitant RMMAX and an expressing method and application thereof. Segment C and segment N of the invention have special amino acid sequence, besides, the invention is modified by sulpho-carboxylic-acid on the segment C, the stability of the opypeptide is raised effectively. The RMMAX of the invention is a novel special excitant of PAC1 receptor, which is combined with the PAC1 receptor stronger and has more advanced function for activating the PAC1 receptor. The RMMAX can be applied to diagnosing and treating diseases concerned closely with the PAC1 receptor. The invention also first finds that the RMMAX has the efficient function for raising the sugar, and shows that the RMMAX can be used for research, diagnosis and treatment concerned about energy metabolism, for instance, hyperglycemia, hypoglycemia and diabetes, etc. The hydrolysate of the RMMAX polypeptide sulpholipid synthesized by the method of the invention provides stability which is ten times more than polypeptide synthesized by chemosynthesis. The expressing method of the invention has high efficiency, low cost and wide application prospect.
The invention provides a combination with functions of increasing bone density and preventing osteoporosis. The combination comprises the following components in parts by weight: 0.5-5 parts of calcium amino acid, 2-8 parts of hydrolyzed collagen, 10-60 parts of diluent, 0.1-15 parts of bonding agent, 1-30 parts of disintegrating agent, 0.01-2 parts of glidant or lubricating agent, 1-30 parts of flavouring agent and 0.01-0.1 part of antiseptic. A small quantity of calcium is added to a large quantity of collagen in the invention. First, a damaged structural net frame is repaired, so that the regularity and the firmness are recovered. Then, the calcium is added, and the calcium can be sequentially precipitated in the net system so as to achieve the functions of increasing bone density and preventing osteoporosis. The combination is used for making food, health-care food or medicines and has large application value.
Although the ankle is often involved in low energy trauma, high-energy trauma may occur, being this considered more serious and more common of affecting young and active men. The purpose of the present study was to evaluate and compare the functionality, pain and quality of life of active and inactive adult individuals whose ankle fracture was surgically treated. Seventy-six patients split into two groups (active, n = 58 X inactive, n = 18), of the men (active, n = 38; inactive, n = 9) and women (active, n = 20; inactive, n = 9) gender participated in this prospective study. The IPAQ, MMSE, SF-36, VAS, sociodemographic and clinical questionnaires were applied in person right after surgery. The SF-36 and VAS questionnaires were reapplied 3 months in average after the surgery. Active and inactive patients of both genders show significant differences (p ≤ 0.05) in the functional capacity and physical aspect domains; and the bodily pain domain revealed significant difference in active and inactive men (p ≤ 0.05) between the periods post-surgical and 3 months after surgery (on average). Moderate and significant correlations were found (p ≤ 0.05) between functional capacity, physical aspect and bodily pain domains of the SF-36 and the VAS pain scores for active and inactive patients of both genders in the final follow-up period. Other significant correlations (p < 0.05) for inactive men (physical aspect and bodily pain) and inactive women (functional capacity and bodily pain) are observed (after 3 months of surgery). Three months after surgery (on average), active and inactive men had functional limitations and pain symptoms. These factors seem to have negatively influenced the patient's social involvement, worsening their quality of life. Most active and inactive patients had a positive self-perception of their general health status, emotional aspects and mental health domains. Regarding active women, we observed lower energy and vitality after the same postoperative period.
Participants in the intervention group will receive on average 4 texts per day consisting of weight related behavioral recommendations, knowledge based questions, and prompts to promote physical activity and weight monitoring. Texts are interactive and personally relevant based upon a baseline questionnaire.
The invention comprises salts of 1,4-dicaffeylquinic acid with lithium, sodium, potassium, magnesium, choline, hexamethylenetetramine and aminoethanol, and the preparation of salts of 1,4-dicaffeylquinic acid by treating said acid with a base, particularly oxides, hydroxides, carbonates and bicarbonates of alkali or alkaline earth metals, quaternary ammonium hydroxides, primary, secondary and tertiary amines, preferably using equimolecular proportions of base and acid and heating in aqueous media until solution is effected.  In examples: (1) 1,4-dicaffeylquinic acid is treated with 10 per cent sodium bicarbonate solution, the mixture filtered, the filter-cake dissolved in hot water, sodium chloride added when solution on cooling deposits the sodium salt of 1,4-dicaffeylquinic acid as the monohydrate; in a similar manner (2), (4) and (7), the potassium, lithium (from lithium carbonate) and magnesium (from MgO) salts are prepared; (3) the acid is dissolved in warm water containing aminoethanol the solution filtered hot and the aminoethanol salt crystallizes as the monohydrate; similarly (5) and (6) are prepared the choline and hexamethylene tetramine salts, the latter crystallizing as the dihydrate.  Solutions of 1,4-dicaffeylquinic acid (and its salts) in various organic and aqueous-organic solvents, particularly polyhydroxylic alcohols and lower aliphatic amides are also described.ALSO:Stable, injectable, therapeutic solutions having choleretic and anticholesterinemic action comprise 1,4-dicaffeylquinic acid or a salt thereof in an organic or aqueous-organic solvent. Specified salts are those of the alkali and alkaline earth metals, primary, secondary or tertiary aliphatic amines, e.g. diethylamine, also choline, hexamine, diethanolamine, dimethylaminoethanol and aminoethanol, and specified solvents include polyhydroxylic alcohols, e.g. 1,2-propylene glycol, lower aliphatic alkylamides, e.g. dimethylformamide, mono- and dimethylacetamide, and polyvinylpyrrolidone.  Specifications 802,668, 810,375 and 816,053, [all in Group IV (b)], are referred to.
The first treatment group (individual care group) will involve 3 sessions held weekly. Each session will last approximately 45 minutes.
Participants will receive a Fitbit wearable tracker, expert guidance, and a personalized exercise prescription to optimize physical activities among lymphoma survivors. The intervention is 12 weeks long, participants are meeting with a kinesiologist every 2 weeks.
The development of a potentially life-threatening serotonin syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions have been reported with SNRIs and SSRIs alone, including sertralinehydrochloride treatment, but particularly with concomitant use of serotonergic drugs (including triptans) with drugs which impair metabolism of serotonin (including MAOIs), or with antipsychotics or other dopamine antagonists. Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Serotonin syndrome, in its most severe form can resemble neuroleptic malignant syndrome, which includes hyperthermia, muscle rigidity, autonomic instability with possible rapid fluctuation of vital signs, and mental status changes. Patients should be monitored for the emergence of serotonin syndrome or NMS-like signs and symptoms.

The concomitant use of sertralinehydrochloride with MAOIs intended to treat depression is contraindicated.

If concomitant treatment of sertralinehydrochloride with a 5-hydroxytryptamine receptor agonist (triptan) is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases.

The concomitant use of sertralinehydrochloride with serotonin precursors (such as tryptophan) is not recommended.

Treatment with sertralinehydrochloride and any concomitant serotonergic or antidopaminergic agents, including antipsychotics, should be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated.
A cosmetic composition for skin immunity increase and skin moisturizing comprising the fermented extracts of sprouts is provided to increase skin immunity and moisturize the skin, and apply into the skin showing contact hypersensitivity by skin sensitization. The cosmetic composition for skin immunity increase and skin moisturizing comprises the fermented extracts of sprouts, wherein the fermented extracts of sprouts are prepared by inoculating yeast into young sprouts of kale(Brassia oleracea L. var. acephala D), broccoli(Brassica oleracea italica), alfalfa(Medicago sativa L.), Brassica oleracea var. capitata f. rubra, Brassica campestris var. narinosa and Fagopyrum esculentum Moench and fermenting them, and extracting the fermented mixture with distilled water, ethanol, hydrous ethanol, butyleneglycol, hydrous butyleneglycol, propyleneglycol or hydrous propyleneglycol. The cosmetic composition is formulated as lotion, nutritive lotion, nutritive cream, massage cream, nutritive essence, sunscreen lotion or sunscreen cream, and the amount of the fermented extracts of sprouts is 0.01-5.0%(w/v) based on the total dry weight of the composition.
BACKGROUND: The association between urbanization and myocardial infarction in China was not fully understood. We aim to evaluate the association between urbanization level and the risk of myocardial infarction.
METHODS: Participants' data from China Health and Nutrition Survey were analyzed. The survey is an ongoing open cohort with a multistage, random cluster process to draw a sample of over 30,000 individuals in 15 provinces and municipal cities. A multi-component score, urbanization index, was used to measure urbanization level. Urbanization index was categorized by cut-off values of 40, 60, and 80. Baseline characteristics were presented as percentage for categorical variables, and mean or median for continuous variables depending on normality. The association of urbanization index and myocardial infarction risk was evaluated longitudinally by a multilevel mixed-effects parametric survival model with urbanization index as a time-dependent variable using Stata software.
RESULTS: A total of 16,565 participants without previous myocardial infarction were involved in the cohort. At baseline, urbanization index was positively correlated with myocardial infarction risk factors, including blood pressure, body mass index, diabetes, and stroke. In the univariate model, urbanization index was associated with risk of myocardial infarction in a "U-shape" manner, with the lowest myocardial infarction risk in urbanization index ranging from 40 to 60 (Hazard Ratio 0.55 and p = 0.013). However, in the multivariate model adjusting for myocardial infarction risk factors and other confounders, urbanization index ≥ 40 was consistently associated with lower MI risks (Hazard Ratio 0.46 and p = 0.002 for urbanization index 40-60; Hazard Ratio 0.56 and p = 0.021 for urbanization index 60-80; and Hazard Ratio 0.44 and p = 0.002 for urbanization index ≥ 80).
CONCLUSIONS: Our study indicated that urbanization of living communities was associated with a reduced risk of myocardial infarction.
Postoperative psychomotor dysfunction is called postoperative cognitive dysfunction, and the incidence of postoperative complications is high, especially in elderly patients undergoing major surgery. This complication; It can be attributed to the anesthetic agents used, their doses, and the duration of the surgery. Although SARS-CoV-2 virus causes an infection called Covid-19 that mainly affects the respiratory tract, data have been obtained that it can enter the nasal mucosa, reach the central nervous system via olfactory fibers or hematogenous way, and infect endothelial cells and neurons. The immune system is activated due to endothelial cell damage, vascular permeability increases, and the risk of thrombosis occurs. Cerebral hypoperfusion promotes Lewy body development, especially by increasing amyloid plaque formation and inducing serine phosphorylation. The formation of these plaques, which are responsible for the development of Alzheimer's and Dementia, suggests that Covid-19 may have long-term neurological complications. In our study, we included patients who were scheduled for cholecystectomy, who had and did not have covid-19 infection. Covid-19 infection (Group 1), no previous (Group 2), COVID-19 and pre-induction low-dose intravenous ketamine (0.5 mg/kg) administered (Group 3), non-covid-19 and pre-induction low-dose intravenous ketamine We aimed to evaluate and compare postoperative cognitive functions in patients (Group 4) administered (0.5 mg/kg). Ketamine is a sedative, hypnotic and analgesic agent and has an effective role in balanced anesthesia. In addition, its use reduces the need for the use of other anesthetic agents. The use of ketamine in normal doses causes a decrease in brain and cognitive functions; The use of sub-anesthetic doses before induction has positive effects on recovery and cognitive functions. Depth of anesthesia with bispectral index continuously before and throughout the operation; The lowest and highest values were recorded by regional cerebral oximetry (rSO2) measurement. Cognitive tests were performed 1 day before the operation, at the 12th hour and 30 days after the operation. MMT (mini mental test), Verbal Fluency Test (verbal fluency test), Clock Drawing Test (clock drawing test) Aldrete recovery scores were evaluated at the 2nd and 5th minutes after extubation. The study included 160 patients, 35-55 young and middle-aged, ASA I and II. Patients who underwent emergency surgery, had malignancy, and had a known chronic disease were excluded from the study.
The study will be performed with a randomized crossover design. After the first assessment of coordinative capabilities children were randomized into two groups. One starts with exercised training for three months. After midterm assessment of the capabilities they will pause for another 3 months and reassessed. The second group will start without training for the first three months. After midterm assessment they will train for three months and have their final assessment.
The invention discloses a medicine of a male genital organ cleaning lotion and a preparation method thereof, and belongs to the field of Chinese medicines. The medicine is prepared from lightyellow sophora root, densefruit pittany root-bark and the like and is prepared into a lotion, paste or cream. The medicinal preparation has a main effect of cleaning male genital organs, and is an external lotion for treating urethritis, balanitis and ulcer, scrotal infection, herpes of the penis, filariasis of scrotum, trichomonad, demodicid mite, crab louse, eczema, perineal sweating, stinking smell, serious itching and the like. Diseases, bacteria and viruses of male genital organs directly infect female mates, cause various diseases of the female genitourinary system, harm the physical and psychological health and fertility of the female seriously, and even cause cancer to threaten life, which is a problem deserving attention. The preparation is prepared through long-term clinical medical practice, study and conclusion, can be used by male and female, and has an exact treatment effect without side effect through long-term clinical application. According to the current data mastered, a special medicine similar to the medicine of the male genital organ cleaning lotion is not discovered at present.
The invention discloses a respiratory tract aerosol inhalation method for preventing flu and a disinfectant. The disinfectant is prepared, filled in an atomizer container and atomized into atomized particles with the size of 0.5 to 1.5 mu m. A user needing to prevent the flu takes a deep breath in a way that the nasal cavity faces an outlet of an atomizer and then the atomized particles are inhaled to the whole respiratory tract to disinfect and inactivate viruses. The user takes a deep breath for 2 to 5 minutes every night and the suction amount each minute is more than 0.6g. The formula of the disinfectant comprises 2 to 3 percent of NaCi, 0.8 to 1.8 percent of ClO2, 0.005 to 0.02 percent of flavoring agent and the balance of water or 0.1 to 0.3 percent of KCl. The aqueous solution of the ClO2 can quickly kill the viruses; and by adding saline, the retention period of the ClO2 in the respiratory tract can be prolonged so as to effectively disinfect the respiratory tract; and at the same time, the diameter of the atomized particles is small, so the disinfectant is uniformly distributed in the respiratory tract without dead areas and thoroughly disinfects the viruses. Even the concentration of the ClO2 is relatively low, the ClO2 also can inactivate 99 percent of the H1N1 viruses in 30 minutes. During a period that the flue prevails, the infection and spread of the flu can be effectively prevented by disinfecting once everyday. The disinfectant is suitable for people who cannot be vaccinated because of some reasons and is also suitable for preventing the influenza A flu of which the virus is HxNy, wherein x and y are equal to 1, 2, 3, 4, 5,...
The invention relates to the technical field of medicines, and provides a 6- (1H-pyrrolo [2,3-b ] pyridine-3-yl) quinazoline-4-amine derivative, and a preparation method and application thereof. The 6- (1H-pyrrolo [2,3-b ] pyridin-3-yl) quinazoline-4-amine derivatives have strong DYRK1A inhibition activity. Wherein compound 32 (ZJCK-6-46) is capable of significantly down-regulating Tau protein phosphorylation levels in Tau (P301L) 293T cells and SH-SY5Y cell models at low nanomolar concentration levels. In addition, compound 32 is capable of improving Okadaic Acid (OA) -induced cognitive impairment in mice by significantly reducing expression of phosphorylated tau protein and exerting neuroprotective effects. Has important practical value and application prospect in the field of preparing anti-Alzheimer disease medicines. The invention also provides a method for preparing the derivative, which has simple and convenient synthesis steps and easy operation.
PROBLEM TO BE SOLVED: To obtain a hair dressing composition capable of spreading over hair near the scalp by forming a mist in jetting using a stock solution for hair dressing and a propellant, attaching the mist to hair and then foaming the mist and rapidly defoaming to form a liquid. SOLUTION: This hair dressing composition is obtained by using 55-97wt.% stock solution composed of 0.3-10wt.% base for hair dressing, 1-70wt.% monovalent lower alcohol and 25-98wt. % water and 3-45wt.% propellant containing >=70wt.% liquefied petroleum gas. Aresin for hair dressing (e.g. anionic resin or cationic resin) or cellulosic thickener (e.g. hydroxyethyl cellulose or carboxymethyl cellulose) is preferably used as the base for hair dressing. For example, ethanol, normal propyl alcohol or the like is used as the monovalent lower alcohol. The composition for hair dressing has preferably 2kg.G/cm<2> , especially preferably 4-7kg.G/cm<2> pressure. The composition is free from unpleasant odor and does not erode a vessel made of a metal.
A method includes receiving geo-location data collected over time period. The geo-location data is associated with a monitoring device. The method further includes receiving motion tracking data of the monitoring device. The motion tracking data is collected over time period. The method includes identifying one or more activities. The activities are identified based on inference rules that identify certain activities to have occurred when at least part of the motion tracking data is correlated to the received geo-location data. The method further includes defining a metric for one or more of the identified activities. The metric is associated to a calendar date. The method includes sending the metric to a calendar application with integration instructions. The integration instructions define the calendar date to which the metric will be added.
This invention relates to non benzene tetrandrine preperaion method. 80-95 percent ethanol solvent and materials are back flow distilled, their weight ratio is 1:2-4, distillation temperature is 80-95 degrees centigrade, distillation times is 2-3 times and each times keeps 2-4 hours. The ethanol extracting solution is depressed and the solvent is recovered to get concentrated dry cream. The dry cream is dissolved by 1/3 to 2 times weight of material 0.5-5 percent acid water to complete precipitation, then they are filtrated, ammonia water is added to adjust PH value to 8-10, 1/5 to equal volume chloroform is added into the solution for 2-5 times extraction, then extracting solution is united, and the chloroform is recovered to get condensate substance. 1 percent to 2times material weight acetone is used to dissolve the condensate substance, filtration and stay for 0.1-6 hours for bleeding, then purity more than 80 percent tetrandrine is got. Repeat the said process, then purity more than 90 percent tetrandrine can be got, and with third recrystallization the purity can reach 95-99 percent. The method can be used to industrial mass production.