anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain the subject substances useful as a reagent for elucidating intracellular signal transmission systems through an antitumor agent or inositol phospholipid metabolic turnover due to its manifestation of a powerful specific inhibitory activity against phosphatidylinositol kinase. CONSTITUTION:A compound expressed by formula I (R is formula II or -CH2-NH2) or its salt, e.g. echiguanine A0 that is a compound in which R is formula II having the following properties. Molecular formula; C10H13O2N7. Molecular weight; 263. Melting point; 215-220 deg.C. Property; basic colorless crystalline powdery substance. Solubility; soluble in water, methanol, etc., and insoluble in acetone, chloroform, etc. The echiguanines A and B are preferably obtained by culturing Streptomyces.sp. MI698-50F1 strain (FERM P-11563) preferably by an aerobic submerged culture method, then purifying and separating the objective substances from the prepared culture filtrate of the culture after the culturing according to a well-known method. The culture temperature is preferably 25-30 deg.C.
A sample of 240 students who identify as Latinx will be recruited. A 2x2 design will randomize students to 1 of 4 peer coaching conditions (n = 60 per condition): 1) demographic matching + standard supervision, 2) demographic matching + reduced supervision, 3) no demographic matching + standard supervision, and 4) no demographic matching + reduced supervision. Students in the demographic matching condition will be assigned to peer coaches who also identify as Latinx, whereas those in the no demographic matching condition will be assigned to peer coaches who do not identify as Latinx. Supervision will either involve individual session review and personalized feedback or not. Students will participate in this project for 24 weeks and will complete brief weekly assessment batteries and longer assessment batteries at baseline and at weeks 8, 16 and 24. Explanatory/intervening variables that are hypothesized to explain treatment effects will also be explored. In addition to the quantitative data collected from the randomized controlled trial, we will collect and analyze qualitative data from the peer coaches via annual focus groups and will evaluate cost-effectiveness specifically focused on costs related to supervision. These data will inform the iterative refinements made to Tier II in the Signature Project.
PURPOSE:To obtain the subject one-phase type cleansing composition, containing a hydrophiic nonionic surfactant, a branched fatty acid, a water-soluble compound having hydroxyl groups, a liquid oil and water, excellent in feeling of use such as spread and slip in application to the skin and good in permeability into fine parts of the skin. CONSTITUTION:The subject composition containing 5-25 wt.% hydrophilic nonionic surfactant (e.g. a polyoxyalkylene alkyl ether), 1-10 wt.% compound (e.g. 2-propylundecanoic acid) expressed by the formula (R<1> and R<2> are H or 1-50C alkyl; p is an integer providing the total number of carbon atoms in the molecule with 14-60), 3-30 wt.% water-soluble compound (e.g. glycerol) having OH groups, 30-80 wt.% liquid oil (e.g. liquid paraffin) an 3-30 wt.% water. The aforementioned composition is a readily handleable gel or liquid form and can be massaged while maintaining smoothness without readily increasing the viscosity even if water is mixed from the outside therein. Furthermore, if water is added, oily ingredients are converted into oil-in-water type emulsified particles and readily removed together with dirt from the skin.
Today, one of the challenges of HIV treatment is to overcome side effects and toxicity of long term antiretroviral therapy. A promising approach may be the simplification of treatment maintenance strategies, sparing certain antiretroviral drug classes. This is a two-year prospective phase II/III, multicenter randomized trial to evaluate the efficacy and tolerance of a lopinavir/ritonavir monotherapy as a maintenance regimen in HIV-infected adults. Enrolled patients must have had stable antiretroviral treatment and HIV-1 RNA below 50 cp/mL over the previous 12 months, and no prior treatment failure. Provided informed consent, 420 patients are randomized in a 1:1 ratio to two open-label treatment groups and receive either lopinavir/r 800/200mg per day or EFV/FTC/TDF 600/200/245 mg per day (fixed dose combination). The main objective is to assess treatment efficacy and tolerance after 2 years. In 80 patients, repeated DEXA measurements are performed during the trial in order to evaluate changes in bone mineral density and in body composition.
The present invention provides a novel cathartic product for the safe and rapid defecation of anuses, which is composed of three kinds of raw materials, namely sodium chloride, glycerin and water. A defecation effect can be generated within 3 minutes to 7 minutes by the cathartic for anuses of the present invention. Compared with the glycerin cathartic for anuses sold on markets, the patient needs 15 minutes to 1 hour to start defecation, and is shortened greatly. The contents of the glycerin and the sodium chloride in the cathartic of the present invention are respectively 50% to 80% and 0.625% to 2.5%. The concentration of the sodium chloride is lower than the concentration of hypertonic saline solution. The electrolyte balance in a patient's body can not be disturbed by the concentration of the sodium chloride, and too much mucosa mucus in a patient's excrement can not be caused either.
Background Advances in surgery have decreased postoperative morbidities but bile leak is still a major issue. Intraoperative cholangiogram (IOC) is considered better in identifying bile leaks and anatomical delineation making its expanded use in hepato-biliary surgeries. Objective To assess the role of intraoperative cholangiogram in major hepatectomy and complex bilio-enteric bypass surgery. Method A single-centered, descriptive cross-sectional study between March 2022 to February 2023 among conveniently sampled 32 patients undergoing Hepato-biliary surgeries. One ampoule of meglumine diatrizoate was instilled into the biliary tract and intraoperative pictures were taken via C-arm to visualize the biliary tree and preoperative and intra-operative pictures were compared. Result A total of 32 patients were included in the study with a median age of 42 years and a male-female ratio of 1:1.67. During the bilio-enteric anastomosis, no intraoperative anastomotic leaks were detected. Two patients experienced postoperative bile leakage that was managed conservatively and eight cases had intraoperative bile leakage which was addressed during surgery. The average duration of hospital stay was 5 days. Conclusion An intraoperative cholangiogram is useful to delineate the biliary tract anatomy, reassure anastomosis, and identify bile leaks in difficult bilio-enteric anastomosis and from liver resection margins intraoperatively.
INTRODUCTION: The ultimate measure of successful abdominal wall reconstruction is a pain-free, complication-free, and durable hernia repair. Open techniques have generally lost favor, but they still have much to offer for patients with skin deficits and excess. The long-term complication rates for open hernia repairs is unknown. Electronic medical records now provide the ability to easily follow patients who have switched medical institutions. Using this tool, we followed a cohort of abdominal wall reconstruction patients who had an early high "success" rate.
METHODS: We performed a retrospective chart review of 101 patients who underwent open ventral hernia repair with a narrow well-fixed retrorectus uncoated polypropylene mesh by a single surgeon (GAD) between the years of 2010 and 2015. These patients were initially reported in a 2016 publication. Patients' post-operative follow-up by any medical provider assessing the abdominal region were studied up until August 2023. Patient demographics, operative reports, and postoperative course were re-reviewed.
RESULTS: A total of 101 patients underwent ventral hernia repair. Mean follow-up time was 7.68 years (range 1.8 - 13.0 years). There were no recurrent hernias across the studied time period and no instances of enterocutaneous fistulas. 15 patients (15%) had abdominal surgery after hernia repair unrelated to their original surgery and 5 patients (5%) reported chronic post-operative pain. 13 patients died in the follow-up period, all unrelated to the abdominal wall surgery.
CONCLUSION: Open well-fixed narrow retrorectus mesh hernia repairs perform well in the long-term without fistulas, extrusions, and hernia recurrence.
If allocated to this arm 'Phenobarbital' (PHB group), the clinician gives an IV bolus of phenobarbital (20mg/kg ). If CSE did not terminate after 5 - 10 minutes, a second dose is given at half the dosage (10mg/kg) and a third dose (10mg/kg) is given if CSE persists 5-10 minutes after that.
Participants will receive an oral dose of milvexian in morning in fed state on Day 1 and IV injection of rFVIIa or placebo matching to rFVIIa on Day 1 after 4 hours post morning milvexian dose in the following treatment sequence: DEF2, EF2D, F2DE, EDF2, F2ED and DF2E; in treatment period 1, treatment period 2 and treatment period 3 respectively where Treatment D=Dose 1 of milvexian+Dose 1 of rFVIIa; Treatment E=Dose 3 of milvexian+Dose 1 of rFVIIa; Treatment F1=Dose 3 of milvexian+Placebo; Treatment F2=Dose 1 of milvexian+Placebo. A washout period of 4 days will be maintained between each treatment period 1, 2 and 3.
NEW MATERIAL:A physiologically active substance, NSH extracted from tissues  with poxes. USE:Tranquilizer, autonomic controller, sedative and antiulcerative: it is applied to various kinds of diseases caused by stresses and autonomic imbalance. The combination with other medicines reduces its side-effects and gives an expectation of synergism. PREPARATION:Sterilely collected tissues with poxes are ground, combined with phenol-water in an amount of 1-5 times that of the tissue to form a milk-like substance, then subjected to filtration or centrifugation. The resultant solution is adjusted in pH near its isoelectric point, heated, filtered to remove protein and made acidic with a mineral acid, then adsorbed on 5-20% activated carbon. The activated carbon is combined with an aqueous alkali to adjust its pH to 10-12 and exudation is effected under heating. The exudate is evaporated to dryness under reduced pressure or freeze dried to give the objective physiologically active substance, NSH.
The invention discloses an external spray for treating viral herpes and relates to a medicine. According to the technical scheme disclosed by the invention, 100cc of the external spray is prepared by the following steps: preparing 15-25mg of poly I-C, 40-60mg of chlorpheniramine, 1500-2800mg of acyclovir, 2,000-2800mg of lidocaine, 15-25mg of vitamin B12, 25-50mg of menthol, 200-300mg of chloramphenicol and the balance of ethanol; and bottling. The spray is used in a spraying manner. The viral herpes is clustered red hill herpes caused when viruses invade the skin or mucosa or superficial nerves; the viral herpes is distributed into a belt along the nerve positions sometimes, and therefore the group of cases are named herpes zoster; the elder and weak patients are serious in pain; some after pain symptoms last for several years; and the patients are painful. The invention aims at providing the external spray for treating viral herpes. The external spray is used for treating skin diseases such as viral herpes and has the effects of restraining viruses, relieving symptoms and shortening the course; and a new medical method is provided.
Adductor canal block will be performed before induction of general anesthesia. Patients will be positioned in the supine position with knee slightly flexed and leg externally rotated followed by ultrasound scanning of the middle of thigh using 13-6 MHz linear array probe. The ultrasound probe will be placed over the anterior aspect of the patient's thigh, mid-point between the inguinal crease and medial femoral condyle. The scan will be focused on the femoral artery pulsations aiming to try to visualize the nerves in the adductor canal on both sides (lateral and medial) of the pulsating femoral artery. 20 ml bupivacaine 0.25% combined with 75 mcg dexmedetomidine will be injected. The study solution will be injected underneath the fascia of sartorius muscle.
Robot-assisted urological interventions require sufficiently deep neuromuscular relaxation (NMR) during the phase of pneumoperitoneum. This is achieved by repeated administration of the non-depolarizing neuromuscular relaxant rocuronium, which is used in clinical routine. The level of relaxation is usually measured with the TOF-Watch relaxometer. This device has limitations in its usability and accuracy in this setting because it is unreliable when the monitored arm of the patient is not accessible for the anaesthetist for visual or tactile assessment of finger movements. The novel TOF-Cuff relaxometry equipment is by design intended to provide constant and reliable quantitative and in vivo calibrated relaxometric values independently of the arm position. The combination of frequently adjusted neuromuscular relaxation in a standardised mode in combination with a reliable relaxometry by TOFcuff promises an improved surveillance of neuromuscular relaxation and a higher safety standard. This investigation aims to test and to define the combined use of the best available drug with the best available relaxometer for general anesthesia in robot-assisted urological surgery.
Patients in SBRT+TACE+Lenvatinib group will take oral lenvatinib within 3 days of randomization and receive TACE 1 day after oral administration of lenvatinib. SBRT will begin within 3 weeks after the first TACE.
1,116,450. Multicomputer systems; indicators. ASSOCIATED ELECTRICAL INDUSTRIES Ltd. 17 Nov., 1966 [19 Nov., 1965], No. 49166/65. Heading G4A. A visual indicator indicates when a peripheral device is connected to a computer and to which computer of a multi-computer installation it is connected. In a two-computer system as shown (Fig. 2), plug P1 of a peripheral device P may be inserted into either socket S1 or socket S2 connected respectively by way of buses 1 and 2 to computers A and B. A lead extending to an indicator board IB (see also Fig. 1, not shown) illuminates either a lamp A or a lamp B, of different colours. Corresponding circuits and lamp pairs may be provided for other peripheral devices (not shown). The computers themselves may be connected to the buses by plug-and. socket connections pA and pB. Means other than plugs and sockets may be provided, e.g. manual switches, relays or a diode system.
Naltrexone, an opioid antagonist that blocks the reinforcing properties of opioid agonists, is often prescribed to preclude relapse to opioid use disorder (OUD) following detoxification. However, few laboratory studies have directly investigated the ability of naltrexone to alter relapse-inducing effects of opioid agonists, including their priming strength in reinstatement studies and their impact in brain regions known to be involved in drug-induced reinforcement in MRI studies. Here we directly address this issue by investigating the effects of continuous exposure to naltrexone on 1) fentanyl-induced reinstatement of drug-seeking behavior, 2) fentanyl-induced patterns of blood oxygenation level dependent (BOLD) activation in the nucleus accumbens (NAcc), and 3) fentanyl-induced changes in NAcc functional connectivity (FC) in awake non-human primates that are engaged in ongoing opioid self-administration studies. We found that naltrexone antagonizes the priming strength of fentanyl as shown by a rightward shift in its reinstatement dose-effect curve and that naltrexone surmountably antagonizes the BOLD response induced by fentanyl. However, while naltrexone also countered fentanyl's effects on NAcc FC, the effects were not surmounted by a higher dose of fentanyl. Together, these data suggest that, in contrast to naltrexone's modulation of fentanyl's effects on behavior and BOLD responses, their interactive effects on FC between multiple brain regions do not reflect their receptor-mediated activity. Additionally, we demonstrated opposing effects in the absence and presence of naltrexone on NAcc FC at baseline (i.e., in the absence of any fentanyl prime) suggesting that naltrexone alters FC at baseline, even though naltrexone appears behaviorally silent in the absence of an agonist prime. Together these data provide additional insight into ways in which naltrexone interacts with opioid agonists, both behaviorally and in the brain. Further understanding the effects of opioid agonists on patterns of FC could help elucidate our understanding of the neural processes that contribute to the initiation of and relapse to opioid-seeking behavior in OUD.
Cardiovascular diseases (CVD) remain the leading cause of death globally as well as here in the United States. Manipulations of the macronutrient (protein, carbohydrate and fat) contents of diet have been used extensively for weight loss and weight control in the past several decades. Low carbohydrate diets, in particular, have gained popularity for weight loss. However, few studies have examined the effects of a diet low in carbohydrates on traditional and novel cardiovascular risk factors in the long term, particularly in contrast to the current dietary recommendations for decreased fat intake to reduce risk of CVD. In this proposal, we plan to conduct a 12-month, parallel-arm, randomized controlled trial of a diet low in carbohydrates versus the currently recommended low fat diet to reduce CVD risk factors among obese adults. The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on CVD risk factors, including blood pressure (BP), body weight and composition, serum lipids, plasma glucose, insulin, adipocytokines (adiponectin, leptin, resistin), and C-reactive protein (CRP) among obese adults. In order to accomplish these objectives we will randomize 130 eligible participants (n=65 in each group) to consume either a diet low in carbohydrates (≤40 g/d) or a diet low in fat (\<7% saturated fat, \<30% total fat). Neither of the diets will be energy-restricted. Participants will meet with a dietitian for one-on-one counseling sessions weekly for the first 4 weeks, then bi-monthly in small group sessions for the next 5 months, and monthly in larger group sessions for the final 6 months of the intervention. Data on both traditional and novel CVD risk factors will be collected at baseline, 3, 6, and 12 months. We hypothesize that a diet low in carbohydrates as compared to a diet low in fat will lower systolic and diastolic BP, body weight, total percent body fat, waist circumference, serum levels of triglycerides, and plasma levels of insulin, glucose, leptin, resistin, and CRP, and increase serum levels of HDL-cholesterol and adiponectin. Because CVD is the most common cause of death here in the U.S. and world-wide, this study has important public health implications. It will provide new information on the potential long-term effects of diets low in carbohydrates on both the traditional risk factors for CVD as well as novel risk factors and inflammatory factors. The results from this study will help to determine if a diet low in carbohydrates as compared to the currently recommended low fat diet can decrease the risk of CVD among obese adults.
A system for generating occlusal loading is provided, including a loading appliance and a controller. The loading appliance includes three load transmission elements and three actuators. The load transmission elements are adapted to be positioned between upper and lower anterior teeth of the patient and between upper and lower posterior teeth on the left and right sides of the patient's mouth, respectively. The load transmission elements are separated from each other. The actuators are coupled to the load transmission elements, respectively. The controller is configured to control the three actuators to actuate the three load transmission elements individually and sequentially, with a rest period between successive actions of the three load transmission elements, to transmit vibration energy from the three actuators to the patient's periodontal tissues of the anterior teeth, the left posterior teeth, and the right posterior teeth.
During this study the subjects will have a bronchoscopy where the study team will collect airway samples to see how the subjects express certain cells. The subjects will also have two blood draws to provide information on the number of inflammatory cells that are present in their blood. This will help the study team determine if mepolizumab might be able to be used in more patients with COPD. The use of mepolizumab in COPD subjects with elevated blood eosinophils has been proven effective. However, the cellular mechanisms in the COPD population are unknown, including the extent to which these subjects express IL-5 in their airway and whether eosinophils are the sole target. Through this study the study team plans to provide proof of concept that mepolizumab could target additional IL-5-expressing immune cells in the airway, including especially PMNs. The study team will also investigate additional feasible biomarkers that could be utilized to predict mepolizumab responsiveness in COPD. The study team is hoping to determine if COPD patients with elevated blood eosinophils will demonstrate increased concentrations of IL-5 in their bronchoalveolar lavage (BAL) fluid and increased expression in their BAL of CD125+ PMNs. To address this hypothesis, the following specific aims will be addressed: To define the expression of IL-5R on PMNs in COPD and to demonstrate elevated concentrations of IL-5 in BALF obtained from COPD subjects with blood eosinophils (≥300/µL).
Epidural analgesia with local anesthetic and opioid is the efficiently good method to relieve labor pain comparing with intravenous opioid analgesic. Many literatures reported effects epidural analgesia for labor eg. prolonging the duration of second stage of labor, increasing the rate of instrumental delivery: vacuum extraction and forceps assisting labor. Some papers revealed the increasing in the rate of cesarean delivery. The main reason is assume to be a failure to progress labor after epidural analgesia. However, the recent report from Cochrane database systematic review showed no relation of epidural analgesia for labor and the increasing in the rate of cesarean delivery. Various factors that may involve in the increasing in the rate of cesarean delivery including the dilatation of cervix at the time of insertion of epidural catheter, nulliparous, size of the fetus or motor weakness after receiving epidural medication.

The rate of cesarean delivery after epidural analgesia for labor has not been reported in our institute. The aim of this study is to elucidate incidence of cesarean delivery in parturient whom received epidural analgesia. Besides, factors associated with the rate of cesarean delivery were studied.
Patients with admission A1C \< 7% will be discharged on same pharmacologic regimen (oral agents, insulin therapy) or linagliptin 5 mg/day. If contraindication to oral anti-diabetics (OAD), discharge patient on linagliptin once daily.