anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The study is a randomized, controlled, two-group intervention trial with pretest-posttest design at three centers. The study will enroll adult End Stage Renal Disease patients receiving hemodialysis treatment who meet the inclusion criteria at the three centers where the study is being conducted. Data for the study will be collected using face-to-face interviews, a patient information form, a hemodialysis treatment information form, the End-Stage Renal Disease Adherence Questionnaire, a Coping and Adaptation Processing Scale, and a "Teach Back Method" questionnaire. Patients participating in the study will receive an educational booklet that will be completed after obtaining expert opinion based on the literature from the researcher. Patients in the intervention group will be trained by the researcher using the "Teach Back Method" in three sessions. Each session will last 45-60 minutes. From the 2nd week of the study, patients' questions will be answered and a 15-minute retraining session will be made in every two weeks. Patients in the control group will undergo a pretest and a posttest, and their routine care and treatment will continue. At the end of the study, patients in the control group will take training booklets.
Participants will receive E7386 twice daily (BID) along with pembrolizumab 200 mg intravenous (IV) infusion once every 3 weeks (Q3W) in 21-day treatment cycle until RP2D is determined in Phase 1b. The recommended dose for Phase 2 part of the study will be based on Phase 1b result. Participants will continue to receive study treatment in Phase 2 part until disease progression, development of unacceptable toxicity, withdrawal of consent, or termination of the study.
Reference formulation. 15-U dose of Insulin Lispro administered SC in one of two periods.
The invention relates to a composition capable of clearing throat and a preparation method thereof. The main materials of the composition comprise 10-40 parts of snow pear, 0.1-5 parts of  fritillaria cirrhosa, 0.5-10 parts of dandelion, 0.1-5 parts of white canary tree fruit, 0.5-10 parts of radix polygonati officinalis, 0.1-5 parts of lilyturf root and 0.1-5 parts of the fruit of Chinese wolfberry. The preparation method comprises the steps of conducting the extraction of snow pear, fritillaria cirrhosa, dandelion, white canary tree fruit, radix polygonati officinalis, lilyturf root and the fruit of Chinese wolfberry, preparing the concrete, mixing and the like. According to the composition, the snow pear and fritillaria cirrhosa have the function of cleaning lung and relieving sore throat, preventing phlegm from forming and stopping coughing. The dandelion and white canary tree fruit have the function of clearing heat and inflammation, detoxicating heat fever, and preventing the dryness-heat and coughing caused by heat fever, thus comprehensively preventing the outbreak of throat disease. In the context of the guidance of traditional Chinese medicinal theory, the composition applies a fully compatible formula, nurtures the outside from the inside, takes care of both the incidental and fundamental and regulates the body health comprehensively, thus achieving the effect of clearing throat. The composition applies the coordinated synergy of a plurality of traditional Chinese medicines, which are not simple superposition. The animal tests and clinical tests all indicate that the composition and its preparation have good therapeutic and preventive functions to throat disease.
BACKGROUND: Nasal cannulas and face masks are common oxygenation tools used in conventional oxygen therapy for patients undergoing endoscopic surgery with sedation. However, as a novel supraglottic ventilation technique, the application of supraglottic jet oxygenation and ventilation (SJOV) in endoscopic surgery has not been well established.
METHOD: We searched six electronic databases from inception to January 16, 2024, to assess the oxygenation/ventilation efficacy and side effects of the of SJOV in endoscopic surgery. The primary outcome was the incidence of hypoxemia. The secondary outcomes were the incidence of respiratory depression and adverse effects (nasal bleeding, sore throat, and dry mouth).
RESULTS: Nine trials involving 2017 patients were included. The results demonstrated that the incidence of hypoxemia was lower in the SJOV group compared with the conventional oxygen therapy (COT) group [9 trails; 2017 patients; risk ratio (RR) = 0.18; 95% confidence interval (CI), (0.11-0.28)]. Subgroup analyses showed that SJOV reduced the incidence of hypoxemia in the high-risk group but had no effect on the low-risk group. The incidence of respiratory depression is lower in SJOV than in COT, but has increased side effects such as dry mouth. There was no statistically significant difference in nose bleeding or sore throat between the two groups.
CONCLUSION: Compared with the COT, the SJOV decreased the incidence of hypoxemia in high-risk patients during endoscopic surgery with sedation. There was an increased risk of dry mouth, but not of nose bleeding or sore throat, during endoscopic surgery under sedation.
PURPOSE OF THE REVIEW: Preserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available. We review the rationale for assessing epicardial adiposity thickness in patients with preserved ejection fraction heart failure and elevated body mass index.
RECENT FINDINGS: Body mass index correlates poorly with visceral, and epicardial adiposity. Visceral and epicardial adiposity enlarges as preserved ejection fraction heart failure progresses. Epicardial adiposity may hasten the progression of coronary artery disease and impairs left ventricular sub-endocardial perfusion and diastolic function. Epicardial adiposity thickness may help monitor the therapeutic response in patients with preserved ejection failure heart failure and elevated body mass index.
PURPOSE: To document the 2-year mortality and seizure recurrence rate of a prospective cohort of patients identified with status epilepticus (SE).
METHODS: Patients presenting to any hospital in the Auckland region between April 6 2015, and April 5 2016, with a seizure lasting 10 min or longer were identified. Follow up was at 2 years post index SE episode via telephone calls and detailed review of clinical notes.
RESULTS: We identified 367 patients with SE over the course of one year. 335/367 (91.3 %) were successfully followed up at the 2-year mark. Two-year all-cause mortality was 50/335 (14.9 %), and 49/267 (18.4 %) when febrile SE was excluded. Two-year seizure recurrence was 197/335 (58.8 %). On univariate analyses, children (preschoolers 2 to < 5 years and children 5 to < 15 years), Asian ethnicity, SE duration <30 mins and acute (febrile) aetiology were associated with lower mortality, while older age >60 and progressive causes were associated with higher mortality on both univariate and multivariate analyses. Age < 2 years and acute aetiology were associated with lower seizure recurrence, while non convulsive status epilepticus (NCSE) with coma and a history of epilepsy were associated with higher seizure recurrence. On multivariate analyses, a history of epilepsy, as well as having both acute and remote causes were associated with higher seizure recurrence.
CONCLUSIONS: All-cause mortality in both the paediatric and adult populations at 2 years was lower than most previous reports. Older age, SE duration ≥30 mins and progressive aetiologies were associated with the highest 2-year mortality, while febrile SE had the lowest mortality. A history of epilepsy, NCSE with coma, and having both acute and remote causes were associated with higher seizure recurrence at 2 years. Future studies should focus on functional measures of outcome and long-term quality of life.
Goal of this pilot study is to identify the effects of 2 over-the-counter mouthrinses on the microbiome of the oral cavity and the GI tract. We will investigate 2 mouthwashes, plus an additional non-treatment group (water rinse only). One mouthwash has antimicrobial activity (ListerineR, Johnson \& Johnson Consumer Healthcare Products, Skillman, New Jersey); the other targets microbial products only (Lumineux Oral Essentials Clean and Fresh MouthwashR, Los Angeles, CA). Oral plaque will be collected with a sterile swab using a commercial collection kit on Day 0, Day 30, Day 60, Day 90, and Day 180 of the study. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit. Subjects will rinse 2x daily for approximately 180 days using either mouthwash or water.
Participants who score a 9 on the eSAGE. Interventions include neuropsychological testing.
This is a single arm dose escalating study. Patients will be treated with open label KA2507 (HDAC6 inhibitor) capsules.
The present invention discloses a rheumatism plaster which is composed of raw radix aconite, raw wild aconite, datura flower, Chinese yellow azalea, tripterygium wilfordii, raw rhizoma arisaematis, spatholobus stem, Chinese angelica, red sage root, clematis chinensis, safflower, asarum, cinnamon, benne oil and yellow lead. The thirteen kinds of the medicine are put into the benne oil and are fried and scorched by soft fire. The yellow lead is used for collecting paste. Nux vomica powder is added to the paste, and the paste with the nux vomica powder is evenly mixed. The thick paste is put into water for removing fire toxin and is cooled and stored. The present invention uses pure traditional Chinese medicine as raw materials and has the functions of dispelling wind and eliminating dampness, promoting blood circulation and relaxing muscles and tendons, and eliminating swelling and alleviating pain. The present invention mainly treats rheumatism, rheumatoid arthritis and arthralgia and has good effects without toxic or side effect.
BACKGROUND: The utilization of dermal fillers for cosmetic procedures has increased dramatically in the past several years, and so is the number of reported adverse events and complications. Most of these reports are centered on extraoral facial structures such as skin, nose, forehead, and eyes. However, as this report illustrates, intraoral complications are also possible and require appropriate management. Our extensive search of the medical and dental literature has failed to yield any such report.
METHODS AND RESULTS: An injection of dermal filler composed of hyaluronic acid for managing a deep nasolabial fold resulting in an arterial occlusion is presented. Patient exhibited facial skin necrosis, with ecchymoses and crusting, extending to the right eye. Transient diplopia and vision changes were also present. Additionally, intraoral necrosis of the palatal mucosa extending from the right central incisor to the molars and approaching the midline was noted. Patient was managed palliatively until complete re-epithelization was noted, with no further loss of periodontal attachment.
CONCLUSION: This case illustrates a rare oral complication of extraoral injection of a dermal filler, and its management. The clinicians should be aware of the potential risks of these cosmetic procedures. Early detection and timely management may prevent lasting damage and discomfort. Additionally, some of these complications may require a well-coordinated multidisciplinary involvement to restore health and functions (plastic surgeon, dermatologist, ophthalmologist, and a periodontist).
KEY POINTS: Why is this case new information? Previous reports of adverse effects linked to dermal fillers were limited to extraoral structures such as the facial skin, nose, forehead, and eye. To the authors' best knowledge, this is the first and only documented case of intraoral necrosis following dermal filler injection What are the keys to successful management of this case? The most important step in managing intra-arterial filler injection and occlusion is the immediate injection of hyaluronidase enzyme to minimize the extent of tissue necrosis. In the case of ocular involvement, immediate referral to an ophthalmologist is required What are the primary limitations to success in this case? Success of managing the adverse effects of vascular occlusion following filler injection depends on several factors, including the anatomical area of occlusion, its extend, along with timely treatment.
Contrast agent administration is controlled for medical imaging. Anamnesis data of an examination object is received. A maximum value of a substance quantity is determined based on the anamnesis data. Planning information that has information with regard to a planned sequence of a procedure is received. The procedure includes an administration of substance. An instantaneous value of the substance quantity is acquired. A required value of the substance quantity for the planned procedure is determined based on the instantaneous value and the planning information. A procedure parameter is based on the required value and maximum value of the substance quantity. The procedure parameter has information with regard to a deviation or conformity between the required value and the maximum value of the substance quantity.
Needle procedures applied to children for diagnosis and treatment cause fear, anxiety, and pain. In cases where children's pain and fear cannot be controlled, health professionals and parents may experience feelings of stress, helplessness, and guilt. Many approaches reduce pain and anxiety in children during painful procedures. The most commonly used of these approaches is the distraction technique, also known as the distraction technique, which is constructed with cognitive and behavioral processes. There are many methods used to divert attention. Some of those; watching cartoons, inflating balloons, creating balloons by blowing foam, directing techniques, parent coaching, using virtual reality (VR) glasses, listening to music, kaleidoscope, and using distraction cards. The research is a randomized controlled experimental study designed to determine the effects of two different methods (watching 360-degree cartoons with virtual reality glasses and watching cartoons with a tablet) during the blood collection procedure in children, on the level of pain, fear, and anxiety experienced by children.
Place of residence (urban versus rural) is a contextual determinant of health that has received less attention in the food insecurity literature. The purpose of this study was to assess the urban-rural disparity in the prevalence of food insecurity and weight status among US children. Using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 with three age groups of children (2-5, 6-11, and 12-17 years old), the associations of weight status and child and household food security status by urban-rural residence were examined using Rao-Scott Chi-square tests. Statistical significance was set at p < 0.05. Children living in urban areas were significantly more likely to experience household food insecurity (29.15%) compared to their rural counterparts (19.10%), among those aged 6-11 years. The associations between children's weight status and child and household food security status were significant for children living in urban areas overall and different age groups but not for children living in rural areas. These trends were more pronounced in older age groups. Given the link between food insecurity and higher obesity rates, particularly among urban children, this study highlights the importance of incorporating food security interventions into future obesity prevention programs.
<P>PROBLEM TO BE SOLVED: To produce equol effective for prevention or treatment of diseases such as prostatic cancer, breast cancer, osteoporosis, and climacteric disturbance, from daizein or a material containing the daizein in high conversion efficiency in a short time as much as possible.  <P>SOLUTION: The equol-producing composition such as a food and drink contain an FJK1 strain of a new species of a microorganism, which has excellent daizein assimilability of producing the equol by the assimilation of daizein, and the daizein or a material containing daizein. The equol-producing method utilizes the assimilability, and is used for producing the equol from the daizein or the material containing the daizein. The equol-containing composition is utilized as the food and drink or the like containing the equol. When the FJK1 strain is used, about 100% conversion into the equol is observed in 48 hr culture time, and excellent effect is exhibited in the conversion speed and conversion efficiency.  <P>COPYRIGHT: (C)2010,JPO&INPIT
BACKGROUND/OBJECTIVES: Delivery by cesarean section (CS) compared to vaginal delivery has been associated with increased risk of overweight in childhood. Our study examined if the presence or absence of labor events in CS delivery altered risk of overweight in early childhood (1-5 years) compared to vaginal delivery and if this association differed according to infant sex.
SUBJECTS/METHODS: The study included 3073 mother-infant pairs from the CHILD Cohort Study in Canada. Data from birth records were used to categorize infants as having been vaginally delivered, or delivered by CS, with or without labor events. Age and sex adjusted weight-for-length (WFL) and body mass index (BMI) z scores were calculated from height and weight data from clinic visits at 1, 3 and 5 years and used to classify children as overweight. Associations between delivery mode and child overweight at each timepoint were assessed using regression models, adjusting for relevant confounding factors including maternal pre-pregnancy BMI. Effect modification by infant sex was tested.
RESULTS: One in four infants (24.6%) were born by CS delivery; 13.0% involved labor events and 11.6% did not. Infants born by CS without labor had an increased odds of being overweight at age 1 year compared to vaginally delivered infants after adjustment for maternal pre-pregnancy BMI, maternal diabetes, smoking, infant sex and birthweight-for-gestational age (aOR 1.68 [95% CI 1.05-2.67]). These effects did not persist to 3 or 5 years of age and, after stratification by sex, were only seen in boys (aOR at 1 year 2.21 [95% CI 1.26-3.88]).
CONCLUSION AND RELEVANCE: Our findings add to the body of evidence that CS, in particular CS without labor events, may be a risk factor for overweight in early life, and that this association may be sex-specific. These findings could help to identify children at higher risk for developing obesity.
The invention relates to medicine, and more particularly to therapeutic agents, and is intended for inhibiting reperfusion injury to organs in the case of ischaemia-reperfusion syndrome. The invention can be used in surgery, cardiology, critical care medicine, emergency medicine, and rehabilitation, inter alia in the case of myocardial infarction, as well as in pharmacology to create novel drug compositions for treating patients with ischaemia-reperfusion syndrome. For this purpose, it is proposed that a phospholipid emulsion containing an effective amount of dihydroquercetin be used in patients with ischaemic organ and limb injury, where the phospholipid emulsion has the following composition in grams per 100 ml: 3.5±0.5 glycine; 3.5±0.8 egg lecithin; 0.35±0.1 dihydroquercetin; the balance water. The claimed use envisages intravenous and/or oral administration of the emulsion as part of a combined therapy. Intravenous administration of the emulsion is carried out 2 minutes prior to reperfusion in doses of 0.29-5.7 ml/kg. The technical result is that of reducing the area of ischaemic injury by administration of the emulsion. This result is achieved by inhibiting oxidative stress caused by ischaemia-reperfusion syndrome, as well as by restoring cell membranes.
PURPOSE: To obtain the oil and fat having platelet coagulation-inhibiting, antibacterial and mildew-proofing activities and useful as food, pharmaceutical product, etc., by crushing a scaly bulb of garlic after water is added, adjusting the pH of the liquid, adding an oil and fat to the liquid, and producing and accumulating ajoene by storing under specific conditions. CONSTITUTION: Scaly bulb of 100 pts.wt. of garlic is crushed after 0-100 pts.wt. of water is added. The crushed material is manually squeezed through a nylon filter, etc. After the pH of the obtained juice is adjusted to 5.5-8.5, the juice is added with an oil and fat consisting of fatty acid triglyceride having medium length of chains, etc., those materials are stirred by a homo-mixer, etc., and the obtained mixture is kept at 0-55 deg.C for 3hr to 7 days. An ajoene mixture consisting of Z-ajoene of formula I and E-ajoene of formula II whose molar ratio is >=4 is produced and accumulated in the oil and fat. Thus, the objective ajoene-containing oil and fat is obtained through the process consisting of the contact of the treated garlic with an oil and fat.  The obtained oil and fat has platelet coagulation-inhibiting, antibacterial and mildew- proofing activities and useful as a pharmaceutical product such as a treating agent for thrombosis, arteriosclerosis, hypertension, etc., an antibacterial and mildew-proofing agent, etc., health food, etc.
Bempegaldesleukin (NKTR-214) will be given in combination with VB10.NEO in up to 10 patients with SCCHN. Treatment with individualized VB10.NEO immunotherapy will commence as soon as the patient-specific VB10.NEO vaccine is available and if the patient-specific vaccine meets all pre-specified product release criteria after manufacturing. Bempegaldesleukin (NKTR-214) will be given after at least 4 doses of VB10.NEO.
A 50-year-old female was diagnosed with gastric hyperplastic polyps 7 years before and was followed up at another hospital. She was referred to our hospital because of the growth of gastric polyps and progression of anemia. She had no family history of polyposis. The polyps were observed only in the stomach, increased in size and number, and the erythematous edema got worse. Endoscopic mucosal resection (EMR) of the gastric polyp was performed. Pathologically, the gastric polyp was hamartomatous polyp, and the intervening mucosa between polyps showed no atypical structure without inflammation. Given that gastric juvenile polyposis (GJP) was clinically suspected, a genetic test using peripheral blood was performed. Target resequencing and Sanger sequencing analysis revealed a nonsense mutation in the SMAD4 gene at codon 169. The mutation was detected at a low frequency of 11%, and considered a mosaic mutation. Therefore, she was diagnosed with a sporadic GJP, and total gastrectomy was performed. Immunostaining of SMAD4 for the resected specimen showed a mixture of stained and unstained area in the epithelium of the polyp, indicating partial loss of SMAD4 expression. To our knowledge, this is the first reported case of GJP with a nonsense SMAD4 mutation at codon 169 in a mosaic pattern.