anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The evaluation of morphologic features, such as inflammation, gastric atrophy, and intestinal metaplasia, is crucial for diagnosing gastritis. However, artificial intelligence analysis for nontumor diseases like gastritis is limited. Previous deep learning models have omitted important morphologic indicators and cannot simultaneously diagnose gastritis indicators or provide interpretable labels. To address this, an attention-based multi-instance multilabel learning network (AMMNet) was developed to simultaneously achieve the multilabel diagnosis of activity, atrophy, and intestinal metaplasia with only slide-level weak labels. To evaluate AMMNet's real-world performance, a diagnostic test was designed to observe improvements in junior pathologists' diagnostic accuracy and efficiency with and without AMMNet assistance. In this study of 1096 patients from seven independent medical centers, AMMNet performed well in assessing activity [area under the curve (AUC), 0.93], atrophy (AUC, 0.97), and intestinal metaplasia (AUC, 0.93). The false-negative rates of these indicators were only 0.04, 0.08, and 0.18, respectively, and junior pathologists had lower false-negative rates with model assistance (0.15 versus 0.10). Furthermore, AMMNet reduced the time required per whole slide image from 5.46 to 2.85 minutes, enhancing diagnostic efficiency. In block-level clustering analysis, AMMNet effectively visualized task-related patches within whole slide images, improving interpretability. These findings highlight AMMNet's effectiveness in accurately evaluating gastritis morphologic indicators on multicenter data sets. Using multi-instance multilabel learning strategies to support routine diagnostic pathology deserves further evaluation.
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for multiphoton imaging has been disclosed. These fluorophores are based upon the fluorene ring system, known to exhibit high fluorescence quantum yields, typically >0.7, and possess high photostability. They have been functionalized with moieties to act, e.g., as efficient amine-reactive fluorescent probes for the covalent attachment onto, e.g., proteins and antibodies. The synthesis and the single-photon spectral characteristics, as well as measured two-photon absorption cross sections of the reactive fluorophores in solution are presented. Spectral characterizations of bovine serum albumin (BSA) conjugated with the new reactive probe is presented.
The invention relates to a synthetic method for a folic acid-modified water-soluble rare-earth up-conversion luminescence nanocrystalline. The synthetic method comprises the following steps: firstly, activating folic acid; then, adding the activated folic acid to a cysteine-modified rare-earth up-conversion luminescence nanocrystalline aqueous dispersion, and conducing a reaction for a certain time under the conditions of normal pressure, normal temperature and light shielding to form a folic acid-modified nanocrystalline; finally, conducting separation and purification so as to obtain the folic acid-modified water-soluble rare-earth up-conversion luminescence nanocrystalline. The folic acid-modified water-soluble fluorescent nanocrystalline material has the advantages of uniform size, stable structure, higher up-conversion fluorescence intensity, high biocompatibility and the like. The synthetic method can be applied to surface modification of nanocrystalline doped with different rare earth ions. The product can be applied to the up-conversion fluorescence imaging of hela cells, with obvious effect and good targeting. Therefore, the material has a potential biological application value in the targeting imaging of cells.
In this study, the toxicity of the pesticide cypermethrin and the protective properties of royal jelly against this toxicity were investigated using Allium cepa L., a model organism. Toxicity was evaluated using 6 mg/L cypermethrin, while royal jelly (250 mg/L and 500 mg/L) was used in combination with cypermethrin to test the protective effect. To comprehend toxicity and protective impact, growth, genotoxicity, biochemical, comet assay and anatomical parameters were employed. Royal jelly had no harmful effects when applied alone. On the other hand, following exposure to cypermethrin, there was a reduction in weight increase, root elongation, rooting percentage, mitotic index (MI), and chlorophyll a and b. Cypermethrin elevated the frequencies of micronucleus (MN) and chromosomal aberrations (CAs), levels of proline and malondialdehyde (MDA), and the activity rates of the enzymes catalase (CAT) and superoxide dismutase (SOD). A spectral change in the DNA spectrum indicated that the interaction of cypermethrin with DNA was one of the reasons for its genotoxicity, and molecular docking investigations suggested that tubulins, histones, and topoisomerases might also interact with this pesticide. Cypermethrin also triggered some critical meristematic cell damage in the root tissue. At the same time, DNA tail results obtained from the comet assay revealed that cypermethrin caused DNA fragmentation. When royal jelly was applied together with cypermethrin, all negatively affected parameters due to the toxicity of cypermethrin were substantially restored. However, even at the maximum studied dose of 500 mg/L of royal jelly, this restoration did not reach the levels of the control group. Thus, the toxicity of cypermethrin and the protective function of royal jelly against this toxicity in A. cepa, the model organism studied, were determined by using many different approaches. Royal jelly is a reliable, well-known and easily accessible protective functional food candidate against the harmful effects of hazardous substances such as pesticides.
Participants will wear a pedometer for 14-15 weeks and receive a weekly step count target each week. Commitments will be made as in the Private/Private condition. In addition, one message will be posted to Facebook at the beginning of the week that says how many days the participant thinks they will meet their walking target the following week, and how they did on their previous weekly commitment. An email will also be sent directly to 3 friends the participant chose with the same announcements.
The present invention relates to a cosmetic composition particularly for the make-up of the facial skin, the lips and the eyelashes. It contains as essential ingredients a particular silicone-containing polyurethane. The particular silicone, used as pre-polymer in the polyurethane of the invention is an alkoxylated, bis-hydroxyalkyl group terminated polydialkylsiloxane, in which the reactive OH— group is attached to a carbon atom. The balance contains the usual cosmetic excipients, colorants and other cosmetic additives, particularly clays, waxes and solvents. By the use of the particular silicone-containing polyurethane, improved film-forming properties of the composition are obtained, and the composition is transfer-resistant and easy to apply and skin friendly and comfortable in use. By introducing different kind of chain extenders into the silicone-containing polyurethanes, their physical, rheological and cosmetic properties can be tuned according to the formulator's needs.
NEW MATERIAL:A compound shown by the formula I . USE:An antiallergic. PREPARATION:1,2-Thiazolo-4-amino-5-cyanoimidazole shown by the formula IIis heated in the presence of formamide, preferably by the use of formamide itself as a solvent, at 150-200 deg.C for 5-10hr to give 6-amino-7,8-thiazolopurine. The compound shown by the formula II as a raw material is obtained by reacting N-cyanoiminothiazolidine shown by the formula III with chloroacetonitrile in a solvent such as DMF, etc. in the presence of a base (e.g., alkali metal hydride compound, etc.) to give 2-(N-cyanoimino)-3-cyanomethylthiazolidine shown by the formula IV, subjecting this compound to ring closure in a solvent such as DMF, etc. in the presence of a catalytic amount of a base.
Viruses, and particularly RNA viruses, have high mutation rates. Hence, antiviral agents that have been developed to date targeting protease or reverse transcriptase of viruses have quickly lost their effectiveness and resistant viruses have emerged. Also, in recent years, viral diseases caused by various new viruses such as SARS, avian influenza, and the hepatitis C have become social menaces. Therefore, the development of a novel antiviral agent that can cope with a virus resistant to an existing drug or a new virus and has a wide range of applications has been demanded. The present invention provides a novel anti-RNA viral agent and a method for use thereof. The present invention further provides an anti-RNA viral agent that is also effective against a new virus or a drug-resistant virus, and a method for use thereof.
Light pollution is a potential risk for intestinal health in humans and animals. The gut microbiota is associated with the development of intestinal inflammation induced by extended exposure to light, but the underlying mechanism is not yet clear. The results of this study showed that extended exposure to light (18L:6D) damaged intestinal morphology, downregulated the expression of tight junction proteins, and upregulated the expression of the NLRP3 inflammasome and the concentration of pro-inflammatory cytokines. In addition, extended exposure to light significantly decreased the abundance of Lactobacillus, Butyricicoccus, and Sellimonas and increased the abundance of Bifidobacterium, unclassified Oscillospirales, Family_XIII_UCG-001, norank_f__norank_o__Clostridia_vadinBB60_group, and Defluviitaleaceae_UCG-01. Spearman correlation analysis indicated that gut microbiota dysbiosis positively correlated with the activation of the NLRP3 inflammasome. The above results indicated that extended exposure to light induced intestinal injury by NLRP3 inflammasome activation and gut microbiota dysbiosis. Antibiotic depletion intestinal microbiota treatment and cecal microbiota transplantation (CMT) from the 12L:12D group to 18L:6D group indicated that the gut microbiota alleviated intestinal inflammatory injury induced by extended exposure to light via inhibiting the activation of the NLRP3 inflammasome. In conclusion, our findings indicated that the gut microbiota can alleviate intestinal inflammation induced by extended exposure to light via inhibiting the activation of the NLRP3 inflammasome.
Thirty subjects were recruited from outpatient rehabilitation of neurologically injured patients with limited hand function. Their basic information was recorded, including basic abilities and pen-holding posture, etc. Using three different angles of 3D printing writing aids, the writing efficiency and the satisfaction of the aids are evaluated by the writing task and the Satisfaction with Assistive Technology.
PURPOSE:To provide a skin cleaner having good infiltration into periphery of skin, good touch, excellent cleansing effect and semi-transparent or transparent appearance by compounding an one phase type composition, comprising a hydrophilic nonionic surfactant, a specific water-soluble compound, etc., and a specified powdery material. CONSTITUTION:The skin cleaner contains an one phase type composition, comprising a hydrophilic surfactant (e.g. polyoxyethylene alkyl ether), a hydroxyl group-containing water-soluble compound [e.g. propylene glycol or isoprene glycol (produced by Kurare Co.)], a liquid oil (e.g. liquid paraffin, squalane, polyisobutene) and water and a powdery material (e.g. silicic acid, calcium silicate) having a difference of 0.1, preferably 1.35-1.63, between the refractive indices of the powdery material and the liquid oil.
PTSD is an anxiety disorder that can develop after exposure to an event in harm to the life or physical integrity of oneself or others has occurred or was threatened. People with PTSD have persistent frightening thoughts and memories of their ordeal and often feel emotionally numb, especially with people to whom they were once close. Effective treatments for post-traumatic stress disorder are available, and research is yielding new, improved therapies that can help reduce symptoms of PTSD. Prolonged exposure (PE) therapy is a brief cognitive behavioral therapy that has been effective in treating symptoms of PTSD in adults. However, no treatments have been proven effective for the treatment of PTSD in adolescents. This study will compare the effectiveness of PE therapy versus non-trauma directed active psychotherapy in reducing the symptoms of PTSD in adolescents. In addition, this study aims to refine the existing PE treatment protocol for adolescents with PTSD.

Participants in this single-blind study will be randomly assigned to receive either PE therapy or AP. All participants will receive 12 to 18 therapy sessions, which will be conducted weekly. Assessments of PTSD symptoms, depression, and overall functioning will be conducted at baseline, immediately post-treatment, and 3 months post-treatment.
Diltiazem has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal exercise work loads.

In animal models, diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential. Diltiazem produces relaxation of coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose dependent decreases in systemic blood pressure and decreases in peripheral resistance.
Artificial chemical products are widely used and ubiquitous worldwide and pose a threat to the environment and human health. Accumulating epidemiological and toxicological evidence has elucidated the contributions of environmental chemical contaminants to the incidence and development of chronic diseases that have a negative impact on quality of life or may be life-threatening. However, the pathways of exposure to these chemicals and their involvements in chronic diseases remain unclear. We comprehensively reviewed the research progress on the exposure risks of humans to environmental contaminants, their body burden as indicated by blood monitoring, and the correlation of blood chemical contaminants with chronic diseases. After entering the human body through various routes of exposure, environmental contaminants are transported to target organs through blood circulation. The application of the modern analytical techniques based on human plasma or serum specimens is promising for determining the body burden of environmental contaminants, including legacy persistent organic pollutants, emerging pollutants, and inorganic elements. Furthermore, their body burden, as indicated by blood monitoring correlates with the incidence and development of metabolic syndromes, cancers, chronic nervous system diseases, cardiovascular diseases, and reproductive disorders. On this basis, we highlight the urgent need for further research on environmental pollution causing health problems in humans.
A system and a method for determining the authenticity of a pharmaceutical product. The product is actively cooled to a temperature below ambient temperature. One or more thermographic IR images of the product are acquired in a wavelength or wavelength spectrum selected from the mid wave IR (MWIR) to very long wave IR (VLWIR) spectrum. At least one of the images is acquired while the temperature of the product is below ambient temperature. The acquired one or more images of the product or a quantified value deduced therefrom are compared with a signature of a reference drug. The comparison is displayed, thereby enabling determination of the authenticity of the product.
The study is designed as a two-part, non-interventional prospective cohort study of up to 20-40 patients. In Part A, patients will be initially assessed on a battery of tests to determine operational feasibility. Between 5-10 patients are expected to complete Part A. Following Part A the battery of tests may be reduced or modified before proceeding to Part B. In Part B, the same patients from Part A and the remainder of the cohort (15-35 pts) will be scheduled for two visits separated by 1 day and up to 2 weeks. Part B will assess the variability of the battery of tests due to confounding variables such as disease progression. Additional visits over the course of one year from the first retest visit will be offered in order to better characterize the natural history decline and any impact to the battery of tests.
In the bibliotherapy-based psychoeducation program sessions, techniques such as information and discussion based on the bibliotherapy method were included. Brief information will be given for 5-10 minutes in each session. At the end of the sessions, exercises will be given to reinforce the knowledge and skills acquired by the group members in the sessions and to transfer them to daily life, and the sessions will be concluded.
An important step towards successful drug targeting with nanoparticles is developing a method to coat the nanoparticles with a useful drug. BSA was used by us to mimic the actual drug for its cost effectiveness during initial trials. We have successfully immobilized BSA onto three (PEG, PEMA and glutamic acid) out of four different surfactant capped nanocomposites. We found that the BSA immobilized particles showed excellent colloidal stability in water and stayed well suspended without any sign of agglomeration or settling. The suspended particles were easily accumulated using a magnet and could be re-dispersed readily. These properties indicate that the BSA immobilized iron oxide nanocomposites are excellent candidates for directed drug convection (DDC).
Intraplaque neovascularization (IPN) is considered a leading mechanism causing carotid plaque destabilization. We provide an objective and comprehensive summary of the biology, imaging techniques, and treatment options related to carotid IPN. Plaque neovascularization has been reported to originate mainly from the adventitial vasa vasorum as a response to hypoxia. The leakage and rupture of neovessels lead to the formation of extravasations and foci of inflammation that destabilize the plaque. Vascular endothelial growth factor and its receptors are key regulators of neoangiogenesis. Neovascularization can be analyzed by advanced computed tomography and magnetic resonance imaging. The basic tools for the ultrasound assessment of IPN are contrast-enhanced ultrasound, superb microvascular imaging, and ultrasound molecular imaging. A promising direction of research seems to be the identification of patients with advanced plaque neovascularization. A simple test assessing low-velocity flow in the IPN can detect patients at risk of stroke before they experience rupture of defective neovessels and intracerebral embolism. In addition to surgical treatment, the stabilization of carotid atherosclerotic plaque can be supported pharmacologically. Statins have the best-documented role in this respect. The ideal moment of intensified therapeutic intervention in patients with previously stable carotid plaque is its increased neovascularization. However, the time frame in which intracerebral embolization may occur is unknown, and therapeutic intervention may be too late. The formation of deficient neovessels can currently be non-invasively evaluated with ultrasound. Superb microvascular imaging may change the clinical approach for asymptomatic patients at risk of cerebral ischemia.
FIELD: medicine, endocrinology. SUBSTANCE: invention relates to macroincapsulation of secretory cells and to method of treatment of patients with diseases caused by disturbance of function of secretory cells. Macrogranule with secretory cells, in part with pancreatic islands, is formed from agarose and cover prepared of agarose. Isolated secretory cells are suspended onto agarose in an antibiotic medium, formed macrogranule is incubated in wetted atmosphere containing carbon dioxide and covered with agarose by its dipping in mineral oil. For treatment of patients with insulin-dependent diabetes mellitus prepared macrogranules containing effective amount of secretory cells are implanted to patient. Invention provides functionality and non-immunity of macrogranule that is retained after transplantation for a long time. EFFECT: improved preparing method, valuable properties of macrogranule. 20 cl, 3 dwg, 4 ex
All the patients were subjected to pterygium excision surgery with conjunctival auto-graft under local anesthesia. The graft was fixed by vicryl 8-0 sutures.Ocular irritation symptoms including pain, foreign body sensation and watering were subjectively evaluated. Pain was evaluated using 5 points scale, where (0) indicated no pain; (1) very mild easily tolerable pain; (2) mild pain with discomfort; (3) moderate pain that interfered with the usual activities; (4) severe pain that totally interfered with performing daily activities or sleep. Foreign body sensation and watering of the eye were evaluated with the use of a 4 points abnormal sensation scale, where (0) indicated no abnormal sensation; (1) is somewhat bothersome; (2) is moderately bothersome; (3) is very bothersome. The score of patients' subjective symptoms evaluation were collected in a total score which ranged from zero to a maximum of 10. A total score of 3 or less was considered as minimal irritation (grade I), 4-6 was considered as mild-moderate tolerable irritation (grade II), and 7 or more was considered as severe annoying irritation (grade III).

The degree of localized conjunctival hyperemia involving the nasal quadrant was evaluated 2 weeks, 1,2 and 3 months post-operative using the Cornea and Contact Lens Research Unit (CCLRU) photographic grading scale. In this scale 1 refers to very slight; 2 slight; 3 moderate; 4 severe. Decimal fraction of 0.5 was added to describe the intermediate cases.