anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: We aimed to clarify comprehensively the safety profiles of anti-IL-5 drugs and pinpoint potential safety concerns that may arise in their post-marketing phase.
METHODS: Two researchers conducted comprehensive searches of PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to September 2022. Additionally, we investigated the FDA AE Reporting System for post-marketing adverse event (AE) reports related to anti-IL-5 drugs. The outcomes fulfilled the proportional reporting rate criteria and the Bayesian confidence propagation neural network.
RESULTS: We included 24 published studies in our analysis. The anti-IL-5 treatment group showed an incidence of AEs comparable to the placebo group, and it exhibited a significantly lower frequency of serious AEs. Common AEs were asthma, nasopharyngitis, headache, upper respiratory tract infection (URTI), and bronchitis. The post-marketing data included 28,478 case reports associated with the suspect drugs and 75 suspect safety observations affecting 16 system organ classes. New suspect observations included incomplete therapeutic product effect, URTIs, and pulmonary mass in reports related to mepolizumab. Reports associated with mepolizumab and benralizumab also indicated issues with incorrect technique in device usage and product issues.
CONCLUSIONS: Individual anti-IL-5 drugs' safety profiles largely matched their product inserts. We identified issues like improper device usage, product issue, and URTIs as potential concerns for mepolizumab and benralizumab. Additionally, all anti-IL-5 drugs showed signs of incomplete therapeutic effects.
Children and adolescents with HIV/AIDS are living well beyond the life expectancy that was projected for them in the past. As the number of survivors of vertically or transfusion associated pediatric HIV disease increases, attention to the psychosocial adjustment of these adolescents and young adults becomes increasingly important. Studies in the late 1990s described child and adolescent survivors as generally well adjusted, though difficulties become more apparent as the child approached the age of 18. Nothing is known about these HIV positive youngsters as they enter late adolescence and young adulthood. This study will examine psychosocial factors associated with long-term survival of HIV/AIDS, including the prevalence of psychiatric diagnoses, risk behaviors, evaluation of self competence, and the impact that multiple losses has on the adolescents' emotional well-being. In addition, data will be collected from the primary caregivers on the prevalence of parenting stress compared to national norms. Subjects will include children who have been infected (either perinatally or through transfusion) for at least eight years and who are aware of their diagnosis.
PURPOSE: To deodorize the subject extract having tranquilizing properties and to remove the cause of cloudiness by extracting it from ground valerian root with water, concentrating the extracted solution into a fixed dried content, adding an alcohol, precipitating a gelatinous substance, etc. CONSTITUTION: This extract is extracted from ground valerian root with water at least once and the aqueous extract is concentrated to 10-20% dried content. An alcohol and acetone are added to the concentration and a gelatinous substance to cause the cloudy appearance of a beverage reconstructed from the power is precipitated. The resultant solution is centrifuged to give a water- alcohol mixture or a water-acetone mixture, to which a carbohydrate is added. Then the formed mixture is dried to give an instant deodorized extract powder of valerian root. Preferably, the extraction of valerian root with water is carried out at 65-75 deg.C for 2-5 hours three times. The concentration process is performed at 30-60 deg.C under 2.10<4> to 2.10<3> pa.
Childhood obesity is a complex disorder that appears to be influenced by an interacting system of many factors. Taking this complexity into account, we aim to investigate the causal structure underlying childhood obesity. Our focus is on identifying potential early, direct or indirect, causes of obesity which may be promising targets for prevention strategies. Using a causal discovery algorithm, we estimate a cohort causal graph (CCG) over the life course from childhood to adolescence. We adapt a popular method, the so-called PC-algorithm, to deal with missing values by multiple imputation, with mixed discrete and continuous variables, and that takes background knowledge such as the time-structure of cohort data into account. The algorithm is then applied to learn the causal structure among 51 variables including obesity, early life factors, diet, lifestyle, insulin resistance, puberty stage and cultural background of 5112 children from the European IDEFICS/I.Family cohort across three waves (2007-2014). The robustness of the learned causal structure is addressed in a series of alternative and sensitivity analyses; in particular, we use bootstrap resamples to assess the stability of aspects of the learned CCG. Our results suggest some but only indirect possible causal paths from early modifiable risk factors, such as audio-visual media consumption and physical activity, to obesity (measured by age- and sex-adjusted BMI z-scores) 6 years later.
Patients and caregivers receive standard care as in arm I. Patients and caregivers also participate in yoga sessions 3 times per week over 60 minutes each for a total of 15 sessions.
The purpose of this study is to evaluate efficiency of CACICOL20 for bacterial keratitis. It is a double blinded comparison of epithelial defect in two groups of patients randomized between CACICOL20 and physiological salt solution.
The primary intervention in part 1 includes the interview for item generation with 50 women and the pilot-testing with a separate group of n = 30 women. The primary intervention in part 2 and 3 is the administration of the questionnaire. In part 3, along with the questionnaire being developed, the Body Image Scale (BIS), the Life Orientation Test-Revised (LOT-R), and the upcoming MSKCC BREAST-Q will be given to determine convergent and discriminant construct validity. No other therapeutic or diagnostic agents will be administered.
PURPOSE: A composition for oral hygiene, containing active ingredients from Cucumis melo var. makuwa seeds is provided to prevent and treat oral inflammation and halitosis, to effectively prevent dental caries, and to cleanse oral cavity. CONSTITUTION: A composition for oral hygiene contains a Cucumis melo var. makuwa seed extract liquid, Cucumis melo var. makuwa seed oil, Cucumis melo var. makuwa seed powder, or a mixture thereof as an active ingredient. The composition contains 0.001-30 wt% of the active ingredient. In the Cucumis melo var. makuwa seed extract liquid and the Cucumis melo var. makuwa seed oil, the activity and functionality of the active ingredient are strengthened by infusing camomile oil or a myrrh extract liquid.
Low dose (LD) CD40.RBDv vaccine non adjuvanted or mRNA vaccine (5:1 ratio). If randomized to receive LD CD40.RBDv vaccine non adjuvanted in part 1, the subject will be randomised a second time to receive LD CD40.RBDv vaccine non adjuvanted (1:1) in part 2.
In this case, a woman in her 80s presented to the emergency department with signs and symptoms of acute pancreatitis that began after starting a course of doxycycline. Common aetiologies of acute pancreatitis, including alcohol use, gallstones and hypertriglyceridaemia were ruled out. Less common aetiologies, including recent Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure, hypercalcaemia, malignancy, infection and trauma, were also ruled out, making drug-induced acute pancreatitis the most likely aetiology. After consideration of her medication list, doxycycline was determined to be the offending medication. On discontinuation and treatment with fluids and analgesics, her condition slowly improved.This case illustrates a rare but severe complication of doxycycline use. Determining the aetiology of drug-induced acute pancreatitis is more difficult in older patients due to high rates of polypharmacy. Recognition of doxycycline as an aetiology of drug-induced pancreatitis may allow earlier recognition and intervention in cases of suspected pancreatitis without a clear common aetiology in older patients with polypharmacy.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic having excellent effect on treatment and prevention for pollinosis, e.g. onset control for pollinosis, symptomatic relaxation and symptomatic aggravation prevention, by formulating a cosmetic containing powders, distilled water and an essence of rosaceous plants. SOLUTION: This cosmetic is obtained by adding an essence of rosaceous plants, preferably a rose water and/or an extract from rose perfume distillation residues, into a dispersion solution obtained by dispersing 1 pt.wt. of a cosmetic containing powders into 4 pts.wt. of distilled water and adjusted to pH6 or less in an amount of 0.1-5 wt.%. The extract may be obtained by immersing rosaceous plant bodies or the processed products into a solvent, preferably water, an alcohol, etc., of an amount of 1 to 10 times the former for several days at room temperature or several hours at a temperature near boiling point. As the part of the plant bodies used for extraction, parts containing flowers are preferable. As the rosaceous plant, rose and wild rose are desirable. This cosmetic can arithmetically cope with pollinosis by using antihistamic agents and masks in combination.
PURPOSE:To obtain the microcapsule consisting of a high-polymer electrolyte which can be changed in volume by applying a voltage. CONSTITUTION:The microcapsule is formed of such material with which charges exist always, regardless of the quantity, or under some conditions, in a system including the high-polymer material. The microcapsule obtd. in this way has the function to expand or shrink in an arbitrary place or conditions in addition to the conventional functions of the microcapsule. For example, drugs, dye stuffs, etc., are added into the microcapsule and the inside filled matter can be released from the microcapsule in the form of an arbitrary electrode shape simply by applying the voltage thereto. The microcapsule is thus extremely useful.
Patients with BTP receive a single dose of WSD0922-FU prior to surgery. Patients then undergo surgical resection of brain tumor. After surgery, patients receive WSD0922-FU PO BID on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI during screening and on study, as well as blood sample collection on study.
Hepatitis delta virus (HDV), an RNA virus with two forms of the delta antigen (HDAg), relies on hepatitis B virus (HBV) for envelope proteins essential for hepatocyte entry. Hepatocellular carcinoma (HCC) ranks third in global cancer deaths, yet HDV's involvement remains uncertain. Among 300 HBV-associated HCC serum samples from Taiwan's National Health Research Institutes, 2.7% (8/300) tested anti-HDV positive, with 62.7% (5/8) of these also HDV RNA positive. Genotyping revealed HDV-2 in one sample, HDV-4 in two, and two samples showed mixed HDV-2/HDV-4 infection with RNA recombination. A mixed-genotype infection revealed novel mutations at the polyadenylation signal, coinciding with the ochre termination codon for the L-HDAg. To delve deeper into the possible oncogenic properties of HDV-2, the predominant genotype in Taiwan, which was previously thought to be less associated with severe disease outcomes, an HDV-2 cDNA clone was isolated from HCC for study. It demonstrated a replication level reaching up to 74% of that observed for a widely used HDV-1 strain in transfected cultured cells. Surprisingly, both forms of HDV-2 HDAg promoted cell migration and invasion, affecting the rearrangement of actin cytoskeleton and the expression of epithelial-mesenchymal transition markers. In summary, this study underscores the prevalence of HDV-2, HDV-4, and their mixed infections in HCC, highlighting the genetic diversity in HCC as well as the potential role of both forms of the HDAg in HCC oncogenesis.
Systemic acupuncture is a therapeutic resource in Chinese Medicine that uses needles at specific points in the body, consistent with a system called acupuncture meridians. The aim of the study is to evaluate the effect of systemic acupuncture on dielectric constant, elasticity and skin temperature in healthy individuals. Will be evaluated 360 volunteers aged between 18 and 38 years and both sexes divided into six homogeneous groups. Pregnant women or those with a delay in the menstrual cycle for more than 28 days will be excluded. The evaluation will consist of measuring the dielectric constant at different depths of the skin, elasticity and infrared thermography of systemic acupuncture points. The procedure will be performed in three moments: pre systemic acupuncture (prior to stimulation), immediate post-systemic acupuncture (20 minutes after the start of stimulation), and post systemic acupuncture (40 minutes after the start of stimulation). Systemic acupuncture will be performed on the lower limb, bilaterally, at points E36 (Zusanli) and BP6 (Sanyinjiao), lasting 20 minutes. The multiple comparison ANOVA test will be performed, with statistical significance of 5% (p \< 0.05).
Subjects will be randomized to one of 6 treatment sequences. The randomized study drug will be administered once daily for 7 days throughout each of 3 treatment periods. Each subject will attend an in-house baseline period, the NoTreatment period, and 3 in-house treatment periods, The Active Periods, where the same assessments will be performed. At each of the in-house periods, a MMTT will be carried out on the sixth day of dosing and an insulin withdrawal test will be carried out on the seventh day of dosing.

Postprandial glycemic excursion after a MMTT will be evaluated one day prior to an insulin withdrawal test. An insulin pumps with different modes (such as open loop/closed loop) the mode used at screening will be the mode used throughout the study. Unblinded continuous glucose monitoring (CGM) will be initiated at the start of the 7-day Baseline Period (Day -7) and discontinued at End of Treatment (Day 34).
Approximately half of patients with chronic lymphocytic leukemia (CLL) will never require treatment; nonetheless, they are recommended life-long specialized follow-up (sFU). To prioritize health care resources, local hospital management implemented ending sFU in asymptomatic patients with CLL International Prognostic Index (CLL-IPI) and CLL without need of treatment (CLL-WONT) low-to-intermediate risk, who were covered by universal health care. To evaluate the feasibility and safety of ending sFU, we investigated 3-year clinical outcomes among 112 patients selected by clinical assessment to end sFU as compared with 88 patients selected to continue sFU. Patients who ended sFU were older, but otherwise lower risk compared with patients continuing sFU. Overall survival (OS) was similar in patients ending and continuing sFU (3-year OS, 87% and 80%, respectively; P = .16). Hospital visits per patient-year were lower (median 0.7 vs 4.3, P < .0001) and time to first infection was longer (P = .035) in patients ending sFU compared with those who continued sFU, including shorter in-hospital antimicrobial treatment (median 4 vs 12 days, respectively; P = .026). Finally, 1 in 6 patients were rereferred, including 4 patients meeting international workshop on CLL criteria for need of treatment. This also resulted in a lower 3-year first treatment rate for patients ending sFU compared with patients continuing sFU (4% vs 23%, respectively; P < .0001). In conclusion, it is feasible and safe to end sFU for patients with CLL who have low-to-intermediate risk CLL-IPI and CLL-WONT scores upon thorough clinical evaluation before ending sFU.
PROBLEM TO BE SOLVED: To obtain a water-soluble or water-swellable polymer by adding an N-vinylcarboxamide to an ammonium salt of an acrylamidoalkylsulfonic acid, adding a small amount of a crosslinking substance having at least two olefinic double bonds to the mixture, and polymerizing the entire mixture. SOLUTION: An ammonium salt (49.99-98.99 pts.wt.) of an acrylamidoalkylsulfonic acid, represented by formula III (wherein R3 is H or methyl; and Z is a 1-4C alkylene) is dissolved in an alcoholic solvent, 1-50 pts.wt. N-vinylcarboxamide represented by formula IV (wherein R1 and R2 are each H or methyl) is added to the solution, and 0.01-5 pts.wt. crosslinking monomer having at least two double bonds is added to the solution. The resultant mixture is polymerized in the presence of a free-radical-forming compound. Thus, it is possible to obtain a water-soluble or water-swellable polymer containing crosslinkages derived from the crosslinking monomer, repeating units represented by formula I, and repeating units represented by formula II in a random manner and in a ratio equal to that of the weights of the added monomers.
OBJECTIVE: This study aimed to explore the association between electrophysiological markers of early recurrence after defibrillation in post-myocardial infarction ventricular fibrillation and the therapeutic effects of sympathetic renal denervation, as well as to investigate the potential underlying mechanisms.
METHODS: Experimental research was conducted using an animal model. Myocardial infarction was induced, followed by defibrillation treatment for ventricular fibrillation cases, and the electrophysiological markers of early recurrence were recorded. Subsequently, a subset of animals underwent sympathetic renal denervation intervention, and the therapeutic effects were compared between the sympathetic renal denervation group and the control group. Electrocardiogram monitoring, histological analysis of myocardial tissue, and neurotransmitter measurements were also performed.
RESULTS: Following defibrillation treatment, early recurrence was observed in ventricular fibrillation cases. The electrophysiological markers revealed significantly higher ST segment elevation and T wave changes in the early recurrence group. However, in the sympathetic renal denervation intervention group, the early recurrence rate was significantly reduced, and the electrocardiogram showed improved stability and regularity. Additionally, histological analysis of myocardial tissue demonstrated less cellular damage and lower levels of myocardial fibrosis in the sympathetic renal denervation group. Neurotransmitter measurements revealed a significant decrease in sympathetic nerve activity in the sympathetic renal denervation intervention group.
CONCLUSION: The results of this study indicate an association between electrophysiological markers of early recurrence after defibrillation in post-myocardial infarction ventricular fibrillation and the therapeutic effects of sympathetic renal denervation. Sympathetic renal denervation intervention can significantly reduce the early recurrence rate, improve electrocardiogram characteristics, and alleviate myocardial damage and fibrosis. Furthermore, the reduction in sympathetic nerve activity may be one of the potential underlying mechanisms of sympathetic renal denervation intervention.
PROBLEM TO BE SOLVED: To obtain a glutamine-containing oral composition capable of effectively exhibiting various kinds of useful pharmacological functions possessed by the glutamine in the interior of the body. SOLUTION: This oral composition is characterized in that the composition contains 3-27 pts.wt. glutamine, 2-24 pts.wt. oligosaccharide, 5-45 pts.wt. vegetable fiber, optionally 3-90 pts.wt. reducing sugar and preferably xylitol.
Patients and their partners receive usual care. Once data collection is completed, couples may participate in the DY or PY program of their choice over 60 minutes each. Partners are also offered intervention materials along with five 60 minute optional yoga sessions.
Mechanical ventilation is a life-saving procedure in critically ill patients. This procedure is however not devoid of risks and every effort should be made to shorten its duration. This is best accomplished by the implementation of weaning protocols. Sedation (by opiates and benzodiazepines) is often required in such patients for their comfort and adaptation to the respirator. Withdrawal of sedation in order to allow patients to resume spontaneous breathing may be associated with agitation and confusion that may hinder weaning. In such cases, reinstitution of heavy sedation will prolong ventilator-dependency. It may therefore be interesting to administer a neuroleptic (loxapine) with good anxiolytic properties but that does not notably interfere with spontaneous breathing ability.

Patients will be included when they fail a spontaneous ventilation trial (see inclusion criteria) because of marked agitation. Usual simple clinical (respiratory frequency, P01 measured on the respirator, arterial pressure, cardiac rate) and biological criteria (arterial blood gas determination) and a measurement of sedation/agitation with validated scales (Richmond agitation sedation scale, Ramsay score) will be gathered when a patient is deemed ready for a trial of spontaneous ventilation for weaning. In cases of marked agitation according to validated scales, patients will be given a conventional dose (150 mg) of loxapine by the nasogastric tube and the efficacy of this treatment will be evaluated on the same parameters as above. Demonstration of the facilitation of weaning by this simple strategy would be useful in order to reduce risks associated with mechanical ventilation.
The invention discloses an anti-cold sachet for children. The anti-cold sachet for children is prepared from the following components in parts by weight according to a conventional method: 10 parts of cordate houttuynia, 2 parts of folium isatidis, 5 parts of radix isatidis, 10 parts of radix bupleuri, 2 parts of roots of kudzu vine, 5 parts of cloves, 5 parts of borneol, 2 parts of galangals, 8 parts of cassia twigs, 5 parts of male fern rhizomes, 10 parts of rhizoma kaempferiae, 2 parts of honeysuckles and 5 parts of fructus amomi. The traditional Chinese medicine components are dried, crushed to about 100 meshes, uniformly mixed and filled into small cloth bags to obtain the anti-cold sachets for children, wherein every bag is 10g-15g. The anti-cold sachet for children disclosed by the invention is reasonable in preparation, has the effects of tonifying and strengthening qi, strengthening the body resistance to eliminate pathogenic factors, dispelling the wind and eliminating cold-evil, and warming and regulating bodily functions, has immune functions of resisting viruses, preventing flu infection and strengthening immune function of organisms, and achieves the purpose of endotherapy by external use. The anti-cold sachet for children is especially suitable for hypoimmunity, nasal obstruction, and initial symptoms of a cold of children. By wearing the sachet usually, body functions are improved, and flu infection and scare of children are prevented.
The present invention relates to an immunocyte having higher cytotoxic activity, and a pharmaceutical composition for NK cell therapies, for which high effect can be expected. The present invention provides a cell population including CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative cells. The present invention provides the cell population, wherein the CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative cells further highly express CD11c. The present invention provides a CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative cell, which infiltrates into a solid tumor. The present invention also provides a pharmaceutical composition containing such a cell population and a pharmaceutically acceptable additive. The present invention further provides a method for producing the aforementioned cell population.