anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants follow standard fertility protocols to stimulate the growth of multiple egg follicles. When the egg follicles are mature, the eggs will be removed under sedation, examined by an embryologist under a microscope and the mature eggs will be immediately frozen and kept frozen in tanks at Penn Fertility Care using the same methods of labeling and quality assurance currently in place for frozen embryos.

Eggs will be thawed in the future when the participant wishes to attempt pregnancy and fertilized by standard methods used during In Vitro Fertilization (IVF). Resulting embryos will be placed into the uterus by a procedure that will require approximately 15-30 minutes. The number of embryos to be transferred will be dictated by standard clinical practice. After embryo transfer, subjects will return for serum pregnancy tests at 14 days after the embryo transfer. For those who are not pregnant, there will be no further participation in the study. For those who do achieve pregnancy, trans-vaginal ultrasound will be performed at approximately 6 weeks gestation and weekly thereafter until 8 weeks gestation at which time, they will be referred to their general obstetrician for prenatal care. Participants will be asked to provide the study team with information about birthweight, height, length, gestational age at delivery, complications at delivery, and infant number. This information is routinely collected from patients undergoing conventional IVF in order to maintain quality assurance as recommended by the American Society of Reproductive Medicine. Information will also be collected from the participant's medical records including physical characteristics, medical and fertility history, semen analysis of the partner if appropriate, egg stimulation characteristics including medications, days of stimulation, number of egg follicles, number of mature and immature eggs retrieved, number of eggs frozen, number of eggs thawed, number of embryos, disposition of embryos, pregnancy test results, number of pregnancies that survived the first 12 weeks and prenatal screening tests.
PURPOSE: Can certain characteristics identify as solvable some undiagnosed patients who seek extensive evaluation and thorough record review, such as by the Undiagnosed Diseases Network (UDN)?
METHODS: The UDN is a national research resource to solve medical mysteries through team science. Applicants provide informed consent to access to their medical records. After review, expert panels assess if applicants meet inclusion and exclusion criteria to select participants. When not accepting applicants, UDN experts may offer suggestions for diagnostic efforts. Using minimal information from initial applications, we compare features in applicants who are not accepted with those who are accepted and either solved or still not solved by the UDN. The diagnostic suggestions offered to nonaccepted applicants and their clinicians were tallied.
RESULTS: Nonaccepted applicants were more often female, older at first symptoms and application, and longer in review compared with accepted applicants. The accepted and successfully diagnosed applicants were younger, shorter in review time, more often non-White, of Hispanic ethnicity, and presenting with nervous system features. Half of nonaccepted applicants were given suggestions for further local diagnostic evaluation. A few seemed to have 2 major diagnoses or a provocative environmental exposure history.
CONCLUSION: Comprehensive UDN record review generates possibly helpful advice.
A therapeutic substance is prepared from the subcutaneous cellular tissue of warm blooded animals by the extraction thereof with a liquid solvent containing no oxygen in its molecule followed by desintegration and extraction with a second liquid solvent containing oxygen in its molecule and concentration and removal of the solvent. Preferably, the animals are subjected to red radiation before slaughter.  As liquid solvents of the first kind are mentioned pertroleum ether, carbon tetrachloride trichlorethylene and as liquid solvents of the second kind; diethyl ether, amyl acetate and acetone. Disintegration may be achieved mechanically e.g. by grinding with sand, or chemically, e.g. by digestion with e.g. trypsin, papsin or pepsin and may be followed by adjustment of the pH to 3-4 to precipitate albuminous material.  The product may be compounded in oil in water and water in oil emulsions to make creams and lotions for external application.
PURPOSE: This study aims to determine the relationship between psychological resilience, coping strategies and the fear of cancer recurrence in women who have undergone surgical procedures due to breast cancer.
METHODS: The study was conducted using a descriptive, cross-sectional, and correlational research design. The sample of the study consisted of 252 women. Data were collected with The Patient Information Form, The Psychological Resilience Scale for Adults, The Ways of Coping Questionnaire and The Fear of Cancer Recurrence Inventory.
RESULTS: The mean scores of Psychological Resilience Scale for Adults, Fear of Cancer Recurrence Inventory, and the optimistic and self-confident subscales of the Ways of Coping Questionnaire among participants were found to be above average. The mean scores of the seeking social support and submissive subscales were at a moderate level, while the mean scores of the hopelessness approach subscale were below the moderate level. A moderate positive significant relationship was found between the total mean score of the Psychological Resilience Scale for Adults and the mean scores of the optimistic approach, self-confident approach, submissive approach, and seeking social support subscales of the Ways of Coping Questionnaire.
CONCLUSION: A direct relationship was found between psychological resilience and coping strategies. However, this relationship could not be found with fear of cancer recurrence. It was concluded that the level of psychological resilience and coping strategies among breast cancer survivors can be positively influenced through the implementation of professional interventions aimed at fostering growth, addressing the initial cancer diagnosis, and promoting healthy adaptation.
Peptides or proteins (I), based on the alpha - and beta -chain sequences of fibrin/fibrinogen, or their salts, amides and/or mixtures with each other or other materials, have therapeutic and/or preventive use in human or veterinary medicine. Peptides or proteins of formula R 1R 2N-CH 2-C(O)-Z 1-Z 2 (I), or their salts, amides and/or mixtures with each other or other materials, have therapeutic and/or preventive use in human or veterinary medicine. R 1, R 2H or up to 10C saturated or unsaturated hydrocarbyl; Z 1histidine or proline residue; and Z 2arginine residue or a peptide or protein residue (preferably of 2-30 aminoacids) having an initial arginine residue. An independent claim is included for medicaments containing (I). ACTIVITY : Antiinflammatory; antibacterial; immunosuppressive; Antirheumatic; Antiarteriosclerotic; vasotropic; Thrombolytic; anticoagulant; cytostatic; antipsoriatic. In tests for inhibition of reperfusion damage after surgically induced ischemia in rat cardiac tissue, intravenous administration of Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala-Pro-Pro-Pro-Ile-Ser-Gly-Gly-Gly-Tyr-Arg (Ia) at 800 Microg/kg reduced the precentage of dead tissue from 46% to 29%. MECHANISM OF ACTION : Fibrin antagonist; inhibition of fibrin-mediated adhesion of cells from the blood-stream onto vascular endothelium and/or migration of such cells into tissue; inhibition of deposition and adhesion of fibrin cleavage fragments on vascular walls.
Especially for diseases that are not curable such as metastatic breast cancer (MBC), the maintenance of quality of life is one of the main aims of treatments. Adverse events are well-known side effects of any cytostatic treatment and impact the patients' quality of life. Therefore, new treatment options are developed that should stop or at least slow down metastatic spread of cancer without causing negative side effects in terms of high-grade adverse events. For patients with hormone-receptor positive and HER2 positive MBC the combination of HER2-targeted therapy with endocrine therapy has already been proven to be an effective and in many cases valuable alternative to the combination of HER2-targeted therapy with chemotherapy. The high relevance of HER2-neu-targeted/endocrine treatment combinations derives from the fact that potential chemotherapy-related toxicity can be avoided, which in turn positively affects quality of life. Clinical trials suggest an additional benefit when a CDK4/6 inhibitor is added to the combination of endocrine therapy and anti HER2 treatment. DETECT V is a randomized phase III study comparing the safety and efficacy of trastuzumab plus pertuzumab and the CDK 4/6 inhibitor ribociclib in combination with either endocrine therapy or chemotherapy.
Gelatin capsules Placebo capsules, identical to mirtazapine capsules, 1 capsule every a.m. Medication will be increased by one capsule to 2 capsules at Week 2, barring any side effects.
PURPOSE:To provide a hair cosmetic containing an anionic surfactant, a cationic surfactant and a water-soluble compound derived from chitin or chitosan as a stabilizer, capable of imparting excellent feeling and finished appearance to hair and having excellent stability. CONSTITUTION:The objective hair cosmetic is produced by compounding an anionic surfactant (e.g. natural lauryl alcohol polyoxyethylene sulfuric acid ester), a cationic surfactant (e.g. a quaternary ammonium salt, an amino acid- based cationic surfactant, etc.) and a water-soluble compound derived from chitin or chitosan as a stabilizer. The water-soluble compound is e.g. a water-soluble oligomer produced by decomposing chitin or chitosan to low-molecular weight compound, a partially deacetylated water-soluble chitin having a deacetylation degree of 40-60%, a derivative made to be water-soluble by the introduction of a hydrophilic group to chitin or chitosan, etc., and is especially preferably a partially deacetylated chitin.
The present invention relates to a pharmaceutical composition for preventing or treating anticancer drug resistant breast cancer, the pharmaceutical composition containing an expression or activity inhibitor of SETD1A as an active ingredient. Specifically, it is confirmed that SETD1A is over-expressed in a breast cancer cell compared to a normal breast cell. When a specific gene expression, which is induced to an estrogen receptor in a breast cancer cell, is adjusted, and an expression of SETD1A is made to decrease in a cell, it is confirmed that proliferation of breast cancer cell lines is suppressed, that apoptosis is significantly induced, and that a cell migration is reduced. When tamoxifen is treated onto a cell and an expression of SERD1A is made to decrease, it is confirmed that cancer cell proliferation suppressing, apoptosis inducing, and cell migration suppressing effects are improved compared to when only tamoxifen is treated. Also, when an expression of SETD1A is suppressed in a breast cell which has resistance to tamoxifen, it is confirmed that proliferation of cells is significantly reduced. Accordingly, the composition, containing an expression or activity inhibitor of SETD1A as an active ingredient, of the present invention can be useful for treatment of anticancer drug resistant breast cancer.
The long non-coding RNA (LncRNA) X-inactive specific transcript (XIST) regulates the biological process of osteoclasts and the process of related diseases. This study was attempted to investigate the mechanism of LncRNA XIST acting in osteoclast formation and orthodontic induced inflammatory root resorption (OIIRR). The compression force (CF) -induced cell model and the orthodontic tooth movement (OTM) rat model were designed and established in this study. The expression of LncRNA XIST, miR-130b-3p, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) as well as osteoclast related marker genes and inflammatory factors level were measured in this study. The interaction among LncRNA XIST, microRNA-130b-3p (miR-130b-3p) and PTEN were researched through luciferase activity and western blot assay. Pathological sections were used to analyze root resorption and osteoclast formation. The OTM rat model was successfully constructed, which was characterized by increased tooth spacing and increased root resorption pits. PTEN and LncRNA XIST was overexpressed in OTM group. Mechanism analysis showed that the overexpression of LncRNA XIST enhanced the PTEN level by sponging miR-130b-3p. The overexpression of LncRNA XIST increased the secretion of inflammatory factors and positive osteoclasts number, but inhibited the differentiation of osteoclasts by sponging miR-130b-3p and promoting the level of PTEN. This finding demonstrates that LncRNA XIST regulates osteoclast formation and aggravated OIIRR through miR-130b-3p/PTEN axis, suggesting that LncRNA XIST may be used as potential targets for OIIRR therapy.
FIELD: medicine. SUBSTANCE: method involves showing test to a patient for determining constitutional type and higher nervous activity type. A session includes wrapping patient with Dead sea salts solution applied, applying paraffin wrappings at paraffin temperature of 37-40 C for 20-25 min, massage of foot soles, hand palms and auricles. The sessions are carried out on the background of sounding musical melodies. Musical compositions similar to natural sounds are given for listening to persons manifesting marked unbalanced type of higher nervous activity showing signs of behavioral aggressiveness and having hepatic and gallbladder function disorders (type I). Timbre and rhythm of sounds are selected to be close to those of patient voice. Patients of marked unbalanced type of higher nervous activity distinguished by alternating states of internal comfort and unrestrained gayness having cardiac and intestinal activity function disorders (type II) are treated by listening to musical compositions containing sounds similar to thunder-clap and fire crack. Patients of melancholic weak type of higher nervous activity distinguished by frequently occurring states of sadness and grief and having disorders in lung and large intestine (type III) are treated by giving musical compositions depicting wind noise and performed using wood, copper or bamboo instruments for listening. The patients distinguished by marked unbalanced type of higher nervous activity, lack of self-confidence and availability of emotions like fear and having kidney and urinary bladder disorders (type IV) are treated with listening to musical compositions awakening associations to running springs, water, rain noise and knock. The patients distinguished by marked balanced type of higher nervous activity and rational behavior, calm and balanced temper, suffering from stomach, spleen or pancreas disorders (type V) are treated by giving musical compositions characterized by meditative unclear monotonous sounds. Massage is concurrently combined with aromatherapy selected by satisfying the following conditions. Refreshing oils like German chamomile, Pogostemon patchouli or Citrus aurantifolia are administered to patients of type I. Cooling oils like valerian oil, ylang-ylang oil and mint oil are administered to patients of type II. Grapefruit oil, pine oil and common nutmeg oil are administered to patients of type III. Warming oils like Vetiveria zizanioides, myrtle and eucalyptus are administered to patients of type IV. Lavender oil, myrrh oil and sandal oil are administered to patients of type V. Then patient makes deep breathing exercise with abdominal press being involved into the process. Face, neck, extremities and trunk lymph drain is carried out with the mentioned oils. Extremity lymph drain is carried out along lymph flow. The lymph drain treatment is finished with auricular massage and face massage with Shiatsu elements being applied. EFFECT: enhanced effectiveness of treatment. _
The test group is selected according to the randomization number of enrollment. For experimental group, Prontosan Wound Irrigation Solution is extracted with syringe (Dosage 1-2ml/cm2), and the wound is rinsed 1 cm from the wound. Then, Prontosan wound irrigation solution is used to saturate the gauze, and the gauze is applied to the wound for 15 minutes. After removing the gauze, cover it with oil gauze, then cover it with 8 layers of gauze and wrap it with a bandage.
Sharp debridement of the outer margins of the index DFU using standard technique (curettage or sharp blade debridement) plus a single additional percutaneous debridement of bone and surrounding tissue via the TXB MicroTip for the first treatment session only plus wound care offloading. The index foot ulcer will be dressed with collagen alginate, gauze and roll gauze. Each subject will return for weekly wound assessment, serial sharp debridement if needed and repeat dressing changes. This care will occur for a duration of 12 weeks or until wound closure is confirmed.
Epilepsy, a recurrent neurological disorder involving abnormal neurotransmitter kinetics in the brain, has emerged as a global health concern. The mechanism of epileptic seizures is thought to involve a relative imbalance between excitatory and inhibitory neurotransmitters. Despite the recent advances in clinical and basic research on the pathogenesis of epilepsy, the complex relationship between the neurotransmitter changes and behavior with and without antiepileptic drugs (AEDs) during seizures remains unclear. To investigate the effects of AEDs such as levetiracetam (LEV), carbamazepine (CBZ), and fenfluramine (FFR) on key neurotransmitters in the pentylenetetrazol (PTZ)-induced seizures in adult zebrafish, we examined the changes in glutamic acid, gamma-aminobutyric acid (GABA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), choline, acetylcholine, norepinephrine, dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and adenosine. In this study, we observed that 5-HT and DA levels in the brain increased immediately after PTZ-induced seizures. Behavioral tests clearly showed that all of these AEDs suppressed the PTZ-induced seizures. Upon treatment of PTZ-induced seizures with these AEDs, CBZ decreased the glutamic acid and FFR increased the GABA levels; however, no neurotransmitter changes were observed in the brain after LEV administration. Thus, we demonstrated a series of neurotransmitter changes linked to behavioral changes during PTZ-induced epileptic seizures when LEV, CBZ, or FFR were administered. These findings will lead to a more detailed understanding of the pathogenesis of epilepsy associated with behavioral and neurotransmitter changes under AED treatment.
The invention relates to a traditional Chinese medicine composition for treating bronchial asthma and acute and chronic bronchopneumonia, which is prepared from the following raw materials, by weight, 25-35 g of herba Humuli Scandentis (scandent hop) and 25-35 g of Malandan (autumn sarcandra herb), wherein the bronchial asthma is located in the lung and causes the disease, and the treatment is carried out only by clearing heat and detoxicating after exogenous wind-cold heat without timely treatment. The prescription of the invention is created according to the theory of the method of eliminating diarrhea by division. The "separate-elimination-and-release" method is developed from the "sum-and-method" in the eight methods of traditional Chinese medicine, namely, the pungent-opening bitter-release drugs are used for dredging qi-flowing, regulating qi and resolving depression, reaching the triple energizer, and opening the way of regulating qi and water to remove pathogenic factors and clear damp-heat of the triple energizer. Wherein, the decoction for warming gallbladder is the first party of the method of eliminating diarrhea by dividing into two parts, and the prescription of the invention is based on the combination of the prescription and the experience of many years of clinical experience. Herba Humuli Scandentis (herba Humuli Scandentis) in the recipe is bitter, sweet and cold in nature. The Chinese medicinal composition has the functions of liver, lung, large intestine and bladder meridian, mainly treating clearing heat and detoxicating, promoting diuresis and removing blood stasis, and the marangoni (autumn fish) has bitter taste, cold nature and entering heat meridian, mainly treating blood cooling and hemostasis, clearing heat and promoting diuresis, detoxifying and detumescence, has special efficacy and quick response, has the effective rate of 90 percent for bronchial asthma and acute and chronic bronchopneumonia after clinical application, has the cure rate of 80 percent, and has remarkable effect.
A melanin which is a material produced by enzymatic oxidation of at least one phenol of formula Ar-C=C-CO2X where Ar is 3-R2,4-OH,5R6-phenyl where R2 and R6 are independently selected from H, OH and OMe and X is H or a C1-6 alkyl group is found to have properties making it very useful in compositions for topical application, particularly cosmetic compositions. It is highly soluble in water. It does not form precipitates with dihydroxyacetone, a common ingredient of self-tanning compositions. It exhibits anti-inflammatory and anti-irritant action against various potential irritants, including dihydroxyacetone and surfactants. Thus it may be included in cosmetic compositions to counter irritation as well as for other purposes, eg. as a pigment.
Participants in the combination GLP1RA and SGLT2i and intensive weight loss groupwill be prescribed liraglutide 3mg once daily or semaglutide 1mg once weekly subcutaneous injection plus dapagliflozin 5-10mg together with an intensive dietary and lifestyle approach for 6 months. This typically involves dietary advice to reduce energy intake (and may includea period of partial or total meal replacement), accompanied -if available -by a physical activity programme, both supported by behavioural change techniqueswith regular professional contacts.