anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study was designed to predict the post-weaning weights of Akkaraman lambs reared on different farms using multiple linear regression and machine learning algorithms. The effect of factors the age of the dam, gender, type of lambing, enterprise, type of flock, birth weight, and weaning weight was analyzed. The data was collected from a total of 25,316 Akkaraman lambs raised at multiple farms in the Çiftlik District of Niğde province. Comparative analysis was conducted by using multiple linear regression, Random Forest, Support Vector Machines (and Support Vector Regression), Extreme Gradient Boosting (XGBoost) (and Gradient Boosting), Bayesian Regularized Neural Network, Radial Basis Function Neural Network, Classification and Regression Trees, Exhaustive Chi-squared Automatic Interaction Detection (and Chi-squared Automatic Interaction Detection), and Multivariate Adaptive Regression Splines algorithms. In this study, the test dataset was divided into five layers using the K-fold cross-validation method. The performance of models was compared using performance criteria such as Adjusted R-squared (Adj-[Formula: see text]), Root Mean Square Error (RMSE), Mean Absolute Deviation (MAD), and Mean Absolute Percentage Error (MAPE) by utilizing test populations in the predicted models. Additionally, the presence of low standard deviations for these criteria indicates the absence of an overfitting problem. [Formula: see text]The comparison results showed the Random Forest algorithm had the best predictive performance compared to other algorithms with Adj-[Formula: see text], RMSE, MAD, and MAPE values of 0.75, 3.683, 2.876, and 10.112, respectively. In conclusion, the results obtained through Multiple Linear Regression for the live weights of Akkaraman lambs were less accurate than the results obtained through artificial neural network analysis.
Of the total number of subjects in clinical studies of FACTIVE, 29% (2314) were 65 and over, while 11% (865) were 75 and over. No overall difference in effectiveness was observed between these subjects and younger subjects; the adverse event rate for this group was similar to or lower than that for younger subjects with the exception that the incidence of rash was lower in geriatric patients compared to patients less than 40 years of age.

Elderly patients may be more susceptible to drug-associated effects on the QT interval. Therefore, FACTIVE should be avoided in patients taking drugs that can result in prolongation of the QT interval (e.g., Class IA or Class III antiarrhythmics) or in patients with risk factors for torsades de pointes (e.g., known QT prolongation, uncorrected hypokalemia).

Patients over 65 are at increased risk for developing severe tendon disorders including tendon rupture when being treated with a fluoroquinolone such as FACTIVE. This risk is further increased in patients receiving concomitant steroid therapy. Tendon rupture usually involves the Achilles, hand or shoulder tendons and can occur during therapy or up to a few months post completion of therapy. Caution should be used when prescribing FACTIVE to elderly patients especially those on corticosteroids. Patients should be informed of this potential side effect and advised to discontinue therapy and inform their physicians if any tendon symptoms occur.
Patients receive sotrastaurin acetate PO BID on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
A system and method for processing information after a traffic accident. In the vehicle 402, a gateway receives accident-related data from a first control unit and receives at least one type of health data stored on or collected by a mobile device of the occupant or from sensor(s) embedded in the vehicle. In response to a vehicle crash, the gateway transmits the received health data to an external party 410, such as an emergency service, to prove an indication of the condition of the occupant(s) or severity of the accident to e.g. the emergency personnel. In an alternative, the gateway may provide an access right to at least part of the health data, such as a medical record, that is hosted on an external server 416 to the external party. An autonomous function of the vehicle may also be activated such as self-driving or self-parking or switching on hazard indicators to ensure safety of the victim(s) and avoid chain collisions. Health data may include heart rate, respiratory rate, body temperature etc. The occupant’s mobile device may be paired with the gateway. Location 412 of the vehicle and occupant’s ID may also be reported to the external party.
Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
Catheter-related bloodstream infections (CRBSIs) caused by Lactobacillus spp. and Lacticaseibacillus spp. are rare, and their clinical course and optimal treatment remain uncertain. In this report, we present a 46-year-old male patient who experienced clinically diagnosed Lacticaseibacillus paracasei CRBSI on four separate occasions, despite receiving systemic administration of antibiotics and antimicrobial lock therapy. The patient did not develop L. paracasei bacteremia after catheter removal. This case report furthers our knowledge of CRBSI caused by Lactobacillus and related genera and highlights the need for further research.
Systemic arterial hypertension is an established risk factor for cardiovascular disease (CVD). Among the main modifiable environmental factors of hypertension, the investigators highlight inadequate eating habits, such as low vegetable consumption. Clinical studies have shown that inorganic nitrate from beet juice intake has a protective effect against CVD due to reduced blood pressure, inhibition of platelet aggregation and prevention of endothelial dysfunction. However, there is still no consensus on its benefits of inorganic nitrate in vascular health. Associated with this, there are no previous studies in the literature that correlate the acute effects of inorganic nitrate intake on endothelial function assessed by microvascular reactivity through laser. The objective of the present study is to evaluate the acute effects (single dose) of inorganic nitrate, through the ingestion of beet juice, in the vascular parameters and endothelial function of treated hypertensive patients of both sexes.
Pulmonary arterial hypertension (PAH) is a disorder with a large genetic component. Biallelic mutations of EIF2AK4, which encodes the kinase GCN2, are causal in two ultra-rare subtypes of PAH, pulmonary veno-occlusive disease and pulmonary capillary haemangiomatosis. EIF2AK4 variants of unknown significance have also been identified in patients with classical PAH, though their relationship to disease remains unclear. To provide patients with diagnostic information and enable family testing, the functional consequences of such rare variants must be determined, but existing computational methods are imperfect. We applied a suite of bioinformatic and experimental approaches to sixteen EIF2AK4 variants that had been identified in patients. By experimentally testing the functional integrity of the integrated stress response (ISR) downstream of GCN2, we determined that existing computational tools have insufficient sensitivity to reliably predict impaired kinase function. We determined experimentally that several EIF2AK4 variants identified in patients with classical PAH had preserved function and are therefore likely to be non-pathogenic. The dysfunctional variants of GCN2 that we identified could be subclassified into three groups: misfolded, kinase-dead, and hypomorphic. Intriguingly, members of the hypomorphic group were amenable to paradoxical activation by a type-1½ GCN2 kinase inhibitor. This experiment approach may aid in the clinical stratification of EIF2AK4 variants and potentially identify hypomorophic alleles receptive to pharmacological activation.
The clinical examination will determine anthropometric indexes (weight, height, BMI, waist circumference). The biochemical evaluation will include the measurement of lipid profile, fasting plasma glucose and insulin, liver test function, FT3, FT4, GHRH + Arginine test to detect GHD, plasma IGF-I levels. The instrumental evaluation will include DEXA Total Body and bioimpedance analysis to determine body composition, and liver ultrasounds.
INTRODUCTION: Prediction of the dementia progression is important for patient management. We aimed to investigate the cognitive trajectories of Alzheimer's disease dementia (ADD) and dementia with Lewy bodies (DLB) according to the initial structural change measured by comprehensive visual rating scales (CVRS).
METHODS: We retrospectively included the patients who initially visited the Dementia Clinic of Chonnam National University Hospital between 2010 and 2012. All patients underwent dementia workup including neuropsychological battery (Seoul Neuropsychological Screening Battery, SNSB). We recruited the participant who underwent SNSB annually for 3 years successively. A total of 136 patients of ADD and 63 patients of DLB were included for analysis. We analyzed the decline pattern of the cognitive profile according to the initial brain structural changes.
RESULTS: The general cognitive trajectories between ADD and DLB patients were not different. However, DLB patients showed more rapid decline of cognitive function in language and related function, visual memory function, and frontal executive function. The scores were lower in participants with DLB with the lesser atrophy group in attention, visuospatial function, and frontal executive function. In analysis of the cognitive trajectories, the visual memory domain declined rapidly in the DLB with lesser atrophy group compared with the ADD with lesser atrophy group.
CONCLUSION: We founded that the differences in the visual cognitive profile in ADD and DLB patients in serial follow-up of neuropsychological tests. It is prominent in the mild structural change group of ADD and DLB.
The present invention relates to a Chinese patent medicine for dropping off drug addiction, which is composed of salvia miltiorrhiza, irkutsk anemone rhizome, white mustard seed, silktree albizzia bark, fleeceflower root and borneol. The Chinese patent medicine can activate blood circulation to dissipate blood stasis, induce reuscitation, remove stasis, generate sudation to remove phlegm, remove and expel toxicity, relieve mental stress, alleviate sadness, relax mood, tonify the liver and kidney, regulate five solid organs, strengthen physique, improve ability of resisting evil and diseases, and eliminate drug addiction. Patients who take the Chinese patent medicine can completely drop off drug addiction within about one week feel physical comfort and have reaction of refusing drugs, such as vomitus, nausea, etc. when contacted with the drugs. The present invention has the advantages of small relapse possibility, safety, no toxicity or side effect, short treatment course. The present invention can drug off drug addiction fundamentally.
Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. In most patients no benefit has been associated with using two RAS inhibitors concomitantly. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on EPANED and other agents that affect the RAS.

Do not co-administer aliskiren with EPANED in patients with diabetes. Avoid use of aliskiren with EPANED in patients with renal impairment (GFR <60 mL/min).
PURPOSE:To improve hydration activity by wet synthesizing a raw material slurry from a Ca feed raw material and a P feed raw material, drying the raw material slurry and burning the dried raw material. CONSTITUTION:Raw material components containing a Ca feed raw material and a P feed raw material are dissolved in water to provide an aqueous solution, which is then subjected to wet synthesis at <=30 deg.C to afford a raw material slurry. The resultant raw material slurry is subsequently dried, then burned at >=700 deg.C for 1-10hr and pulverized to provide calcium tertiary phosphate having <=5mum average grain diameter. The resultant calcium tertiary phosphate is mixed with calcium secondary phosphate and/or calcium primary phosphate so as to provide 1.400-1.498 molar ratio (Ca/P). The prepared powdery formulation is subsequently mixed with a liquid formulation so as to afford (3-1):1 weight ratio. Thereby, the objective hydraulic calcium phosphate cement is obtained.
OBJECTIVE: To examine the global literature database on uncomplicated recurrent urinary tract infections (rUTI), this systematic review assesses the availability of rUTI data based on geographic region and elucidates the current state of research and gaps in knowledge.
METHODS: The databases PubMed, Embase, WHO Global Index Medicus, and SciELO were searched for keywords related to rUTI between 2000 and 2023. Three independent reviewers screened studies restricted to female participants age ≥18 years with uncomplicated rUTIs. Studies were excluded if they did not provide a definition for rUTI or did not cite or report an estimate for rUTI prevalence. The review was registered in PROSPERO and conformed to PRISMA guidelines.
RESULTS: The search yielded 2947 studies of which 124 were ultimately included. Convenience samples were used for 91% of studies and sample sizes were 30% n <50, 29% n = 50-99, 22% n = 100-199, 36% n ≥200. Most studies were conducted in Europe (41%) or North America (39%), were prospective (52%), at tertiary centers (49%) and included all ages ≥18 (60%). The most common definition for rUTI was 2 UTI/6 m or 3 UTI/1y (62%). Regardless of study location, most studies cited prevalence estimates for rUTI derived from U.S.-based populations.
CONCLUSION: This study represents the first formal investigation of the global literature base on uncomplicated rUTI. Studies on rUTIs are globally of small scale and definitions used for rUTI are heterogeneous. More studies are needed to ascertain the true prevalence of rUTI outside of North America and Europe.
FIELD: pharmaceutical industry, more particularly preparation of medicinal from garlic. SUBSTANCE: crushed garlic is wetted and then infused in vegetable oil. In order to wet garlic, ethyl alcohol is used with concentration of at least 20 vol %. Infusion is carried out at garlic to oil ratio of 1 wt part of garlic to (1.5-10) volume parts of oil. Invention makes it possible to simplify process. EFFECT: more efficient preparation method. 3 cl, 6 ex, 1 tbl
Images are analyzed using sub-sectional component evaluation in order to augment classifier usage. An image of an individual is obtained. The face of the individual is identified, and regions within the face are determined. The individual is evaluated to be within a sub-sectional component of a population based on a demographic or based on an activity. An evaluation of content of the face is performed based on the individual being within a sub-sectional component of a population. The sub-sectional component of a population is used for disambiguating among content types for the content of the face. A Bayesian framework that includes a conditional probability is used to perform the evaluation of the content of the face, and the evaluation is further based on a prior event that occurred.
Bleeding is a necessary and unavoidable part of spine surgery. It is important to the surgeons and anesthesiologists to know how much blood a patient has lost during surgery in order to care for them in the best way possible. Different methodology has been employed to estimate how much blood is lost during surgery, but unfortunately none of the methods used have been reliable. The study will calculate surgical blood loss by determining perioperative change in red cell volume that is directly measured by using a special method that relies on radioisotope I-131-labeled albumin administration (BVA-100) during the surgery. This benchmarked blood loss estimate will then be compared to estimates calculated using the Gross equation, the Bourke and Smith equation, and the Camarasa formula. In addition, blood loss will be estimated volumetrically by utilizing formulas based on the amount of salvaged blood produced by an intraoperative salvaging system (Cell Saver®). Blood loss estimates based on salvaged blood volume will also be compared to the benchmark.
PURPOSE: A metal nanowire in which gold nanocluster is formed on the surface and a method of binding for the metal nanowire with target material are provided to efficiently bond with target material at high affinity. CONSTITUTION: A metal nanowire in which gold nanocluster is formed on the surface is existed in the composition form. The gold nanocluster has average size of 1-10 nano meters. The gold nanocluster is existed in the density range of 1X10^6 - 1X10^16clusters/cm^2. A manufacturing method of the metal nanowire comprises the following steps: forming a gold thin film layer on a metal board; forming gold - metal island by primary sintering the gold containing metal substrate in a chamber for chemical vapor deposition; and injecting mixing gas into the chamber while secondary sintering the silicon substrate to grow metal nanowire in which gold nanocluster is formed on the surface. [Reference numerals] (AA) Trapping rate(%); (BB) Culturing time(minutes)
PURPOSE: We aimed to identify ocular comorbidities and reasons of blindness in monocular patients and to compare visual outcomes of cataract surgery between monocular and binocular patients.
METHODS: A single-center case-control study was conducted between November 2011 and May 2019 to compare consecutive series of patients needing cataract surgery in Strasbourg University Hospitals, France. Cases were patients with permanent monocular vision loss. Controls were binocularly sighted patients. All patients underwent cataract surgery using phacoemulsification technique. Chart analysis included demographic data, medical history, and surgical determinants data. Student's t tests and Fisher's exact tests were the main methods used for statistical analysis.
RESULTS: Each group included 80 patients. The mean age at the time of surgery was significantly higher in monocular than binocular patients (77 vs. 71 years, p < 0.001). Thirty-two monocular patients (40%) had ocular comorbidities, compared to only 19 (23%) in the control group (p < 0.05). The leading cause of monocular status was amblyopia caused by strabismus (22 patients, 27.5%). Age-related macular degeneration, open-angle glaucoma, and diabetic retinopathy were the three main ocular comorbidities that were observed in the monocular group. Monocular patients had significantly lower visual acuity than the control group (p < 0.01) before and after cataract surgery. Conversely, improvement in visual acuity after surgery was not statistically different between groups (p = 0.054). There was no statistically significant difference in the rate of surgical complications between groups (p = 0.622).
CONCLUSIONS: This study illustrates that cataract surgery in monocular patients is not more complicated than in binocular patients, but that it is significantly delayed.
PURPOSE: The DIANA-5 randomized controlled trial assessed the effectiveness of a diet based on Mediterranean and macrobiotic traditions (macro-Mediterranean diet) in reducing breast cancer recurrence.
PATIENTS AND METHODS: The DIANA-5 study involved 1,542 patients with breast cancer at high risk of recurrence because of estrogen receptor-negative cancer, or metabolic syndrome, or high plasma levels of insulin or testosterone. Women were randomly assigned to an active dietary intervention (IG) or a control group (CG). Both groups received the 2007 American Institute for Cancer Research/World Cancer Research Fund recommendations for cancer prevention. The intervention consisted of meetings with kitchen classes, community meals, and dietary recommendations. Recommended foods included whole grain cereals, legumes, soy products, vegetables, fruit, nuts, olive oil, and fish. Foods to be avoided were refined products, potatoes, sugar and desserts, red and processed meat, dairy products, and alcoholic drinks. A compliance Dietary Index was defined by the difference between recommended and discouraged foods.
RESULTS: Over the 5 years of follow-up, 95 patients of the IG and 98 of the CG developed breast cancer recurrence [HR = 0.99; 95% confidence interval (CI): 0.69-1.40]. The analysis by compliance to the dietary recommendations (IG and CG together) showed that the women in the upper tertile of Dietary Index change had an HR of recurrence of 0.59 (95% CI: 0.36-0.92) compared with women in the lower tertile.
CONCLUSIONS: The DIANA-5 dietary intervention trial failed to show a reduction in breast cancer recurrence, although self-reported diet at year 1 in IG and CG combined showed a protective association with the higher Dietary Index change. See related commentary by McTiernan, p. 931.