anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
There are few histological studies on multifidus after lumbar surgery, and it is not clear whether multifidus changes affect the clinical outcome after lumbar surgery. The aim of this study was to investigate the relationship between multifidus changes and clinical outcomes after lumbar surgery. Patients underwent internal fixation removal after lumbar posterior surgery were enrolled. Patients were divided into a low back pain (LBP) group (n = 15) and a non-low back pain (non-LBP) group (n = 10).The Oswestry disability index (ODI) and visual analog scale (VAS) were completed. 18 patients with lumbar fracture surgery were included as the control group. Multifidus morphological changes were observed by hematoxylin and eosin and Masson staining. The expression of TGF-β1 was observed by immunohistochemistry, immunofluorescence and Western blot. The cross-sectional area (CSA) of the multifidus in the non-LBP group and the control group were greater than those in the LBP group. TGF-β1 expression and gray value ratio in the non-LBP group and the control group were lower than those in the LBP group. The multifidus CSA and TGF-β1 expression in multifidus were strongly correlated with ODI and VAS. Patients with LBP after posterior lumbar surgery suffered from atrophy and fibrosis lesions in the multifidus, and the degree of multifidus lesions was closely related to dysfunction and pain, which might be one of the causes of LBP after posterior lumbar surgery.
PURPOSE:To provide an adhesive for dental use comprising a soln. consisting of a chlorinated solvent having a specified boiling range and an aromatic copolyester or polyestercarbonate. CONSTITUTION:The adhesive for bonding of dental polysulfon resin to dental acrylic resin is prepared by blending 100pts.wt. chlorinated solvent having a boiling point of 30-150 deg.C (e.g. methylene chloride) with 0.3-20pts.wt. aromatic copolyester or polyestercarbonate.
Patients with presentations of somatic symptoms and associated psychological features are named as "somatoform disorders" in psychiatric field. Because the patients' concerns are somatic distress, they often seek help in non-psychiatric clinics. However, the symptoms are usually medically unexplained. This group of diagnoses can be managed from the psychiatric perspective, including medications and psychotherapies. However, many patients do not receive psychiatric management in current medical practice. The goal of this project is to establish an association named "psychosomatic center" for providing comprehensive evaluations and treatments to the somatoform patients. Besides the psychiatrist, a case manager, a clinical psychologist, and a research assistant will be included in this association for the purposes of connection, performing psychotherapy and examinations. After entering the psychosomatic clinic, the investigators will routinely perform diagnostic interview, measure psychological and physiological features, and arrange individualized treatment program. The investigators will follow the important psychological and biological indexes every 3-6 months for building a cohort. At the same time, the case manager will connect with non-psychiatric clinics for ensuring the patients physical problems to be managed. The investigators expect this project to enhance the quality of treatment on the patients, to reduce the excessive examinations for the frequent attenders, and to improve the emotional burden of medical staffs.
The study will involve recruitment of 30 mothers of young children with ASD (ages 3-5 years) and 30 mothers of non-ASD children of similar age, respectively labelled ASD-moms and non-ASD-moms. In Phase 1, the levels of certain folate-related and oxidative stress biomarkers (folate, vitamin B12, vitamin E, homocysteine, methylmalonic acid, urinary isoprostanes) and MTHFR mutation analysis will be measured in all the mothers. The investigators expect that approximately 40-50% of the ASD-mothers and approximately 5-10% of the non-ASD-mothers will have abnormal homocysteine levels. In Phase 2, for those mothers with abnormal homocysteine levels, the investigators will treat them with a standard prenatal supplement for 4 weeks, and re-measure their biomarkers. The investigators expect 75-100% of the non-ASD mothers to respond, but only 25-50% of the ASD-mothers to respond. In Phase 3, for those mothers who did not respond to the standard prenatal supplement, the investigators will treat them with an optimized prenatal supplement for 4 weeks and remeasure their biomarkers. The investigators expect that 75-100% of the mothers of both groups will respond to this improved prenatal supplement.
BACKGROUND: Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis.
METHODS: The study integrated gout genome-wide association study (GWAS) data, single-cell transcriptomics (scRNA-seq), expression quantitative trait loci (eQTL), and methylation quantitative trait loci (mQTL) data for analysis, and utilized two-sample Mendelian randomization study to comprehend the causal relationship between proteins and gout.
RESULTS: We identified 17 association signals for gout at unique genetic loci, including four genes related by protein-protein interaction network (PPI) analysis: TRIM46, THBS3, MTX1, and KRTCAP2. Additionally, we discerned 22 methylation sites in relation to gout. The study also found that genes such as TRIM46, MAP3K11, KRTCAP2, and TM7SF2 could potentially elevate the risk of gout. Through a Mendelian randomization (MR) analysis, we identified three proteins causally associated with gout: ADH1B, BMP1, and HIST1H3A.
CONCLUSION: According to our findings, gout is linked with the expression and function of particular genes and proteins. These genes and proteins have the potential to function as novel diagnostic and therapeutic targets for gout. These discoveries shed new light on the pathological mechanisms of gout and clear the way for future research on this condition.
TDF, a component of SYMFI is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of TDF [see Adverse Reactions (6.2)].

Prior to initiation and during use of SYMFI, on a clinically appropriate schedule, assess serum creatinine, estimated creatinine clearance, urine glucose, and urine protein in all patients.

Avoid SYMFI with concurrent or recent use of a nephrotoxic agent (e.g., high-dose or multiple non-steroidal anti-inflammatory drugs [NSAIDs]) [see Drug Interactions (7.3)]. Cases of acute renal failure after initiation of high-dose or multiple NSAIDs have been reported in HIV-infected patients with risk factors for renal dysfunction who appeared stable on TDF. Some patients required hospitalization and renal replacement therapy. Alternatives to NSAIDs should be considered, if needed, in patients at risk for renal dysfunction. 

Persistent or worsening bone pain, pain in extremities, fractures and/or muscular pain or weakness may be manifestations of proximal renal tubulopathy and should prompt an evaluation of renal function in patients at risk of renal dysfunction.
The invention discloses a new homologue 2-methyl-actinomycin D of actinomycin D and its preparation method. The structure of the compound is determined through comprehensive analysis of nuclear magnetism and mass spectrometry. With a chemical structure as shown in the following figure, the compound is a new homologue of actinomycin D. The preparation method consists of: taking Streptomyces recifensis CGMCC No.5228 as a producing strain; fermenting the Streptomyces in a liquid medium containing soluble starch so as to obtain a mycelium, a fermentation supernatant and various metabolites; extracting the fermentation supernatant and the mycelium from fermentation with chloroform or ethyl acetate, and carrying out extraction, separation and purification, etc. thus obtaining the new compound with the above structure. And cell determination shows that the compound has anti-tumor cell activity. In the invention, a lead compound for developing new antitumor drugs is provided, and is of important value for developing and utilizing medicinal actinomyces resources in China.
The present invention provides a nanocomplex comprising at least one agent and a nanocarrier. The agent is bound to the nanocarrier. The nanocarrier comprises at least one cationic polymer responsive to a stimulus, at least one anionic polymer and at least one lipid. The agent is capable of being released from the nanocarrier upon exposure to the stimulus. The released agent is active. The nanocomplex may be used to deliver the agent into cells, in which the agent may be released from the nanocarrier upon exposure of the cells to the stimulus.
PURPOSE: Neurogenic speech and language disorders-such as acquired apraxia of speech (AOS) and aphasia with phonemic paraphasia (APP)-are often misdiagnosed due to similarities in clinical presentation. Word syllable duration (WSD)-a measure of average syllable length in multisyllabic words-serves as a proxy for speech rate, which is an important and arguably more objective clinical characteristic of AOS and APP. This study reports stability of WSD over time for speakers with AOS (and aphasia).
METHOD: Twenty-nine participants with AOS and aphasia (11 women and 18 men, Mage = 53.5 years, SD = 13.3) repeated 30 multisyllabic words (of three-, four-, and five-syllable lengths) on three occasions across 4 weeks. WSDs were calculated for each word and then averaged across each list (i.e., word length), as well as across combined lists (i.e., all 30 words) to yield four WSDs for each participant at each time point. Stability over time was calculated using Friedman's test for the group and using Spearman's rho for the individual level. Effects of time and word length were examined using robust mixed-effects linear regression.
RESULTS: Friedman's tests and correlations indicated no significant difference in WSDs across sampling occasions for each word length separately or combined. WSD correlated positively with AOS severity and negatively with intelligibility but was not correlated with aphasia severity. Regression analyses confirmed WSD to be stable over time, while WSD calculated from only five tokens (i.e., WSD-5) was less stable over time.
CONCLUSIONS: Results indicate that WSD can be a stable measure over time, at the individual and group level, providing support for its use in diagnosis and/or as an outcome measure, both clinically and for research. In general, WSD outperformed WSD-5, suggesting that it may be better to calculate WSD from more than five tokens. Stability of WSD in other populations and suitability for differential diagnosis need to be determined. Currently, differentiating disorders by speaking rate, alone, is not recommended.
SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.25438735.
An antibody specifically binding to CLDN18.2, an antigen-binding fragment thereof or a variant thereof, and an antibody-drug conjugate. The antibody-drug conjugate comprises a drug-conjugated antibody specifically binding to CLDN18.2, and an antigen-binding fragment thereof, or a variant thereof, and the antibody, the antigen-binding fragment thereof, or the variant thereof comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises HCDR1 as shown in SEQ ID NO. 1, HCDR2 as shown in SEQ ID NO. 2, and HCDR3 as shown in SEQ ID NO. 3; and the light chain variable region comprises LCDR1 as shown in SEQ ID NO. 4, LCDR2 as shown in SEQ ID NO. 5, and LCDR3 as shown in SEQ ID NO. 6. The antibody is a fully human monoclonal antibody binding to a claudin 18.2 protein (such as human claudin 18.2, mouse claudin 18.2 and monkey claudin 18.2), has high ADCC activity, CDC activity and/or claudin 18.2 protein binding stability, and has high endocytosis activity.
As with all therapeutic proteins, there is potential for immunogenicity. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay. Additionally, the observed incidence of antibody (including neutralizing antibody) positivity in an assay may be influenced by several factors including assay methodology, sample handling, timing of sample collection, concomitant medications, and underlying disease. For these reasons, comparison of the incidence of antibodies to NOVOLOG in the studies described below with the incidence of antibodies in other studies or to other products may be misleading.

In a 6-month study with a 6-month extension in adult subjects with type 1 diabetes, 99.8% of patients who received NOVOLOG were positive for anti-insulin antibodies (AIA) at least once during the study, including 97.2% that were positive at baseline. A total of 92.1% of patients who received NOVOLOG were positive for anti-drug antibodies (ADA) at least once during the study, including 64.6% that were positive at baseline.

In a phase 3 type 1 diabetes clinical trial of NOVOLOG, initial increase in titers of antibodies to insulin, followed by a decrease to baseline values, was observed in regular human insulin and insulin aspart treatment groups with similar incidences. These antibodies did not cause deterioration in glycemic control or necessitate increases in insulin dose.
The invention discloses a specific scabies drug and belongs to the medicine field. The drug is mainly used to treat scabies which is very contagious. The drug is mainly composed of a proper amount of mercury, sulfur, tea seed oil, and tea bran. The drug is prepared by the following steps: evenly mixing and stirring sulfur, a proper amount of mercury, and tea seed oil, boiling the mixture at a high temperature to obtain a solid substance, then adding tea seed oil into a container, and grinding the solid substance to obtain paste. The application method of the drug comprises the following steps: painting the grinded drug over the whole body except for the head, especially the wrinkled skin and private parts, so as to attract the mites to the surface layer of skin under the action of the drug; after 24 hours, soaking the prepared tea bran in boiled water for half hour, then filtering to remove the dregs, and washing the whole body by the filtrate when the filtrate is cooled to a temperature of 37 to 42 DEG C or so. The key point of scabies treatment is that the drug should be properly used, the scabies can be radically cured at one time, and at the same time patients should not eat beef, wine, pepper, and food with a fishy smell within seven days.
Previous studies found lipid levels, especially triglycerides (TG), are associated with acute pancreatitis, but their causalities and bi-directions were not fully examined. We determined whether abnormal levels of TG, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) are precursors and/or consequences of acute pancreatitis using bidirectional two-sample Mendelian randomization (MR) with two non-overlapping genome-wide association study (GWAS) summary statistics for lipid levels and acute pancreatitis. We found phenotypic associations that both higher TG levels and lower HDL-C levels contributed to increased risk of acute pancreatitis. Our GWAS meta-analysis of acute pancreatitis identified seven independent signals. Genetically predicted TG was positively associated with acute pancreatitis when using the variants specifically associated with TG using univariable MR [Odds ratio (OR), 95% CI 2.02, 1.22-3.31], but the reversed direction from acute pancreatitis to TG was not observed (mean difference = 0.003, SE = 0.002, P-value = 0.138). However, a bidirectional relationship of HDL-C and acute pancreatitis was observed: A 1-SD increment of genetically predicted HDL-C was associated with lower risk of acute pancreatitis (OR, 95% CI 0.84, 0.76-0.92) and genetically predisposed individuals with acute pancreatitis have, on average, 0.005 SD lower HDL-C (mean difference = - 0.005, SE = 0.002, P-value = 0.004). Our MR analysis confirms the evidence of TG as a risk factor of acute pancreatitis but not a consequence. A potential bidirectional relationship of HDL-C and acute pancreatitis occurs and raises the prospect of HDL-C modulation in the acute pancreatitis prevention and treatment.
PURPOSE: To obtain a bathing agent composition containing sericin, excellent in a moisture-retaining effect and a dryness-improving effect on skin after bathing, and giving the wet and moist skin. CONSTITUTION: This bathing agent composition contains as an active ingredient 1.0-20% of sericin which is a natural protein obtained by extracting silk and which is excellent in moisture absorptivity and water absorptivity. Further, an inorganic salt (e.g. sodium bicarbonate), an inorganic acid (e.g. silica), an organic acid (e.g. benzoic acid), a herb drug (e.g. Atractylodes lancea (Thumb) (DC) radix), a fat or oil (e.g. isopropyl myristate), a pigment, an alcohol, a vitamin, etc., are suitably compounded. The sericin is easily dissolved in water to give a stable property in water as solution, does not require an anxiety about side effects on skins, and is high in safety.  When a bath containing the sericin-containing bathing agent composition is taken, the sericin can easily and uniformly act on the whole parts of the skin, improve the hydration state of the skin corneum, recover the moisture-retaining ability of the skin, treat the dry syndrome of the skin, and give the wet and moist skin.
Diffusion weighted imaging (DWI) and Perfusion-weighted imaging (PWI) are validated MRI techniques that aid in diagnosis, prognosis, and assessment of treatment efficacy and, while they are utilized in select clinical settings, they have yet to make their way into routine clinical practice at most centers. DWI is a non-invasive MRI modality that has demonstrated an ability to predict for a response to radiation therapy in the primary treatment of patients with glioblastoma (GBM). PWI is one collection of measures that includes dynamic susceptibility contrast (DSC) enhancement and dynamic contrast-enhanced (DCE) imaging. The latter methods of MRI-adapted radiotherapy allow the opportunity to direct high-dose radiation to areas most likely to harbor resistant tumor while avoiding regions having a low likelihood of future recurrence. Multiple MRI sequences have been developed and validated that may identify high-risk areas in patients with High-grade glioma (HGG) and the ability to acquire multiple sequential time points creates an opportunity for dynamic radiotherapy that has not previously been explored. The current standard of care in radiotherapy does not incorporate any additional neuroimaging data.

This study hypothesizes that pre- and mid-treatment advanced imaging with (DWI) and (PWI) in patients with HGG can be used to generate an adaptive radiotherapy boost volume that correlates with areas of future recurrence and that this volume has a higher spatial correlation relative to the current standard of care.
Disclosed is a traditional Chinese medicine composition, wherein the composition comprises, in parts by weight: 20-40 parts of Sal ammoniac, 20-40 parts of sodium borate, 10-20 parts of Borneolum syntheticum, 20-40 parts of Bletilla striata, and 15-60 parts of bee honey. The components of the composition follow the compatibility principle of "sovereign, minister, assistant, and courier" to work together and function synergistically, playing parts in eliminating the accumulation of mass and the softening of mass, clearing heat and detoxification, and relieving swelling and pain. The composition is especially suitable for treating esophageal obstructions caused by esophageal cancer and gastric cancer. Further disclosed is a process for preparing the traditional Chinese medicine composition. The preparation steps thereof are simple. All that is required is crushing and blending with bee honey. Preparation can be completed at room temperature and atmospheric pressure with mild conditions; and the process is suitable for industrial mass production.
Dental caries is a disease caused by a shift in pH balance, resulting in the formation of a biofilm composed mainly of cariogenic microflora. The interaction between this microflora and host factors conditions the deceleration or acceleration of the disease. Some biotechnology tools have been tried based on all this research, including probiotics, intended for a selective control of the etiological agents of caries and the maintenance of oral homeostasis.

Methodology: In this study, preschool children belonging to public preschool in Villavicencio and Pasto, Colombia will be invited to participate. After obtaining parent´s informed consent, the children will start commercial milk (nanPro3 Nestlé) intake without probiotic for 3 months. One week after, they will start commercial milk with probiotic during others 3 months. Clinical and microbiological testing of saliva at baseline, 3 m, and 6m will be performed. Differences in salivary pH (before and after a sugar solution), remineralization and demineralization in early Stage Decay and Established decay tooth (according to ICDAS) and quantification of Streptococci of the mutans group. Expected results: Statistically significant decrease in pH drop, demineralization in decay tooth and quantification of Streptococci of the mutans group.
NEW MATERIAL:A naphthalene derivative expressed by the formula (R is H, methyl or ethyl; n is 1, 2 or 3). EXAMPLE:6-Hydroxyethylamino-2,3-dihydro-5,8- dihydroxynaphthalene-1,4-dione. USE:An excellent hair dye, capable of dyeing hair safely and well under mild conditions in a very low concentration with almost no influence of dyeing conditions, and having stable color formation and good storage stability. PREPARATION:The corresponding 2-alkoxyalkylamino-5,8-dihydroxynaphthoqu inone is reacted with a reducing agent, e.g. Na2S2O6, in the presence of an alkali, e.g. KOH, NaOH or Na2CO3, and water, alcohol or a mixture solution thereof or zinc in an aqueous solution of hydrochloric acid to give the aimed compound expressed by the formula. The amount of the above-mentioned com pound to be incorporated is >=0.05wt%, particularly >=0.1wt% based on the total weight of the hair dye.
Dry tamponade is a rare complication of percutaneous coronary intervention. It encompasses a heterogenous pathophysiology and is used to describe hemodynamic compromise secondary to a coronary artery perforation, without free-flowing fluid in the pericardium. Tamponade physiology can result from compressive epicardial, intramyocardial, subepicardial hematomas, or dissecting intramyocardial hematomas. The diagnosis of dry tamponade requires hemodynamic derangement in the context of a compressive hematoma as demonstrated by imaging. Although echocardiography can often help identify dry tamponade, additional studies including right heart catheterization, computed tomography, or cardiac magnetic resonance imaging can inform the exact mechanism and help guide management. This article describes a case of dry tamponade, reviews the existing literature on the topic, and offers expert recommendations on diagnosis and management.