anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients who meet inclusion criteria will be approached upon admission to Labor and Delivery. A study staff member will describe the study and offer participation. If a patient agrees to participate, she will sign research protocol and HIPAA consent forms and receive a copy of these forms. The patient's chart will be flagged, indicating that she is a study participant. The patient's prenatal care and labor and delivery will be managed by her physician per standard of care at the physician's discretion, including routine intrapartum treatment of Group B streptococcus (GBS) colonization using ampicillin. When a participating patient is diagnosed with chorioamnionitis, she will be randomized in a blinded fashion to Arm 1 (Unasyn) or Arm 2 (ampicillin/gentamicin). She will be treated as per standard of care with tylenol, intravenous fluids, and her labor managed per physician discretion. From the time of diagnosis of chorioamnionitis until determination of treatment success or failure in the postpartum period, the patient will receive intravenous antibiotics per the protocol arm to which they have been assigned. If a patient has already been receiving ampicillin for GBS, the ampicillin will be discontinued when the study drugs are initiated. In arm 1, the study drugs will consist of Unasyn 3 grams intravenously every 6 hours, plus intravenous normal saline placebo dose every 8 hours. In arm 2, the study drugs will consist of gentamicin 1.5mg/kg intravenously every 8 hours plus ampicillin 2gm intravenously every 6 hours. For all patients, clindamycin will be given intravenously at the time of clamping of the umbilical cord in the event of a cesarean delivery, and continued as part of the antibiotic regimen as per standard of care for cesarean section in the setting of chorioamnionitis. With the exception of the saline placebo doses, both the Unasyn regimen and the ampicillin/gentamicin regimen are efficacious and widely utilized regimens for the treatment of intrapartum chorioamnionitis, and do not represent a deviation from standard of care. After delivery, if the patient experiences a treatment failure as defined below, her medical care will be managed at the discretion of the attending physician as per standard of care, and her antibiotic regimen will be unblinded. After delivery, prior to discharge from the hospital, the patient will be asked to answer a short questionnaire enquiring about side effects experienced during treatment for chorioamnionitis. The patient may receive a phone call within 14 days of delivery to assess whether she has received treatment for postpartum complications at an outside institution after discharge from the hospital.
Before carrying out each session of the intervention, each subject included in the experimental group will have a sports bandage on both ankles. The intervention by motor control will consist of the application of a series of Core exercises. The exercises will be carried out with the subjects in different positions of prone, lateral and supine position, for the Core musculature. The exercises will be repeated 10 times each and there will be 8 different exercises: roll up, mermaid, raised crossed, stretch two leg back, shoulder bridge and leg pull up. The duration of each session will be 15 minutes, with two sessions per week, during a period of 4 weeks.
Electronic devices and gadgets are mostly used for official and personal needs in this modern era. This increased usage leads to poor posture, especially in young adults. The FSP is the most common incorrect posture in youngsters. A study on posture correction shows the prevalence of rounded shoulders is 84% in the young adult age group of (18 to 24 years). The misaligned posture causes changes in anatomical structure leading to many musculoskeletal problems. Along with the musculoskeletal system, FSP also decreases chest wall mobility, lung capacities, and overall respiratory function. The respiratory muscle's proper functions is need to expand the thoracic cavity . The pectoralis muscles function is to elevate the rib cage and its tightness leads to lower chest expansion. Rhomboids play a role in stabilizing the scapula which helps the serratus muscle in forced inspiration. Weakness of middle and lower trapezius muscles causes the inability to straighten the back, thus affecting the ability to raise and expand the chest properly. Currently, for posture correction, usually in the form of conservative treatments such as stretching and strengthening exercises, McKenzie's exercises, Pilates, shoulder support braces, electrical modalities, etc are used to correct or reduce FSP. It is a dire need to find out the best physiotherapy approach for the correction of forward shoulder posture as well as improvement in pulmonary function that is not time-consuming like other exercise interventions. If the effectiveness of kinesio taping on pulmonary function is verified it will contribute to future use as the most suitable and less time-consuming approach in youngsters with FSP.
OBJECTIVE: Cognitive behaviour therapy (CBT) for fatigue in chronic fatigue syndrome (ME/CFS) leads to a significant reduction of fatigue and disability and is available in different treatment delivery formats, i.e. internet-based, individual face-to-face and group face-to-face. The aim of this study was to investigate whether moderation of the effects of CBT by clinically relevant depressive symptoms varies between CBT delivery formats.
METHODS: Data from six randomised controlled trials (n = 1084 patients) were pooled. Moderation of clinically relevant depressive symptoms (Brief Depression Inventory for Primary Care) in different treatment formats on fatigue severity (Checklist Individual Strength, subscale fatigue severity), functional impairment (Sickness Impact Profile-8) and physical functioning (Short Form-36, subscale physical functioning) was investigated using linear mixed model analyses and interaction tests. Differences in percentages of patients no longer severely fatigued post-CBT were studied by calculating relative risks.
RESULTS: The moderator effect of depressive symptoms on fatigue severity varied by delivery format. In internet-based CBT, ME/CFS patients with depressive symptoms showed less reduction in fatigue, and were more often still severely fatigued post-treatment than patients without depressive symptoms. In individual and group face-to-face CBT, no significant difference in treatment effect on fatigue severity was found between patients with and without depressive symptoms. No moderation was found for the other outcomes.
CONCLUSION: In internet-based CBT, ME/CFS patients with comorbid depressive symptoms benefit less, making face-to-face CBT currently the first-choice delivery format for these patients. Internet-based CBT should be further developed to improve its effectiveness for ME/CFS patients with depressive symptoms.
An a priori sample size calculation was completed. To achieve 80% power and an alpha of .05, the study team needed a sample size of 68 total with 34 participants in each group.The study will be a double-blind randomized control trial. Patients will be recruited based on surgery type (hysteroscopy) and consented using a written consent by the research coordinator with sufficient time to ensure patient comprehension and allow for any questions. The consent process will happen in the pre-operative appointment. Participants will then be randomized to either the standard of care of 80mmHg or the experimental pressure of 60 mmHg for uterine filling pressure via an automated randomization program. The physician performing the surgery and the patient will not know what group they are assigned to. The procedure involved in the study will be hysteroscopy. Hysteroscopy is a procedure that is used to diagnose and sometimes treat intrauterine pathologies. In order to visualize the uterus, pressurized saline is used to distend the uterus.

In this study, the specific hysteroscopic procedure will involve the removal of uterine fibroids with a MyoSure Hysteroscopic Morcellator device. These tissue samples will be collected and sent to Pathology to be weighed. During the surgery, the surgeon will be able to request an adjustment pressure if visualization is not adequate. Physicians will start with a pressure of 80mmHg. Once physician is ready to introduce the myosure hysteroscopy device, the pressure level will then be randomized. During the procedure, monitoring will be done by anesthesia through the use of pulse oximetry and measurement of vitals during the Monitored Anesthesia Care. There is also real-time monitoring of hysteroscopic fluid deficit via the fluid management system that is attached to the hysteroscopic pump. Fluid deficit can also be confirmed by the nurse who manually counts the amount of fluid used during theprocedure. Per policy, once a 2500mL deficit is reached, the procedure is terminated. After the surgery, the surgeon will fill out a questionnaire that measures the outcomes of surgeon satisfaction and visualization during the procedure. The other end points of procedure time, specimen weight, volume of normal saline used, any changes in pressure needed during the surgery, and whether the patient required Lasix post-operatively will also be collected at this time.
The invention relates to a compound traditional Chinese medicine for preventing and treating coxey and a preparation method of the compound traditional Chinese medicine, belonging to the technology of the veterinary-use traditional Chinese medicine. The formula of the compound traditional Chinese medicine is based on the Chinese veterinarian theory, and belongs to a scientific formula according to the demand of pharmacy of dialectical therapy, and the compound traditional Chinese medicine is prepared from dandelion, folium isatidis, astragalus membranaceus, radix sophorae flavescentis, rhizoma ligustici and liquorice. By adopting water boiling extraction method, impurities in an extracting solution are removed through filtering, centrifugation and sedimentation, and an oral liquid is prepared for preventing and treating coxey. When used for treating the coxey, the liquid is mixed with water to achieve the concentration of 37.5mg/mL, and is drunk by chicken with diseases; when used for preventing the coxey, liquid is mixed with water to achieve the concentration of 5.0mg/mL, and is drunk by chicken with diseases. The clinical pharmacodynamics test result shows that when the compound traditional Chinese medicine is used for treating the coxey, the effective rate is 100%, and the cure rate is 96%. When used for preventing the coxey, the total coxey is 100%. The compound traditional Chinese medicine belongs to a pure traditional Chinese medicine preparation, is free of toxic or side effect and free of residue, and has very good prevention and treatment effects for the coxey.
Some 7.1 million Americans and an estimated 250,000 Veterans actively using VHA are Myocardial Infarction (MI) survivors. To date, most guideline interventions focus on a single patient condition, but ambulatory post-MI patients are frequently more complex, multiple comorbidities, and conflicting guidelines applicable to them. For example, whereas JNC-6 guidelines for the treatment of hypertension suggest pharmacological treatment at blood pressures above 140/80 mm Hg, to be initiated with diuretics or beta-blockers as first line agents, other guidance suggests that for post-MI patients with diabetes, treatment cut-offs should be lower and ACE-inhibitors may be considered as optimal first-line agents. On October 1, 2002, the University of Alabama at Birmingham (UAB) began a study funded by the National Heart, Lung, and Blood institute (NHLBI) as an RO1 (Kiefe, PI (25%), Weissman, co-PI (20%)) to conduct a randomized trial, MI-plus to increase provider adherence to guidelines for post-MI patients. That NHLBI-funded study targets Medicare beneficiaries and their primary care providers in Alabama. Its primary goal is to develop and test with a randomized controlled trial, an Internet-based multimodal guideline implementation strategy. The investigators propose, herewith, to extend and adapt this study to a nationwide sample of VA post-MI patients and their primary care providers in the VA.
PURPOSE:To increase safety of liposome and to form stable liposome by producing an agent for liposome with 2-(1-N-2-fatty acid ester alkylamino) ethylphosphoric acid salt of specified formula. CONSTITUTION:To a tetrahydrofuran soln. dissolved 2-hydroxy-N- acylalkylaminoethanol of formula I, where R and R' are alkyl group contg. 10-20 carbon atoms and alkenyl group contg. 9-19 carbon atoms, respectively, phosphorus pentaoxide is added in the amt. of 10 times mol and is reacted for 2-10hr with reflux. After cooling, a base is added and then, by concentrating and desalting, the agent for forming liposome consisting of 2-(1-N-2-fatty acid ester alkylamino)ethylphosphoric acid salt of formula II, where R and R' are the same meaning in formula I and M is Na, K, ammonium or triethanolamine ion, is obtd.
PROBLEM TO BE SOLVED: To obtain the subject composition useful as a makeup cosmetic such as solid emulsified foundation excellent in portability. SOLUTION: This water-in-oil emulsified composition is solid and contains pref. 1-3wt.% of 12-hydroxystearic acid, powder, pref. 0.5-3-wt.% of a surfactant, 20-40wt.% of water, and pref. 1-15wt.% of an acylated cholesterol analogue (e.g. acetylated lanolin). It is preferable that the average hydroxyl value of the ingredient(s) other than the above water, 12-hydroxystearic acid and powder is <30 and the surfactant is a lipophilic nonionic surfactant and <6 in HLB number.
A randomized control trial will be performed on the effect of vaginal HPV self-sampling on screening attendance, targeting women age 35-69 who have not attended screening for at least 10 years. The women will be randomly allocated to one of three interventions: (i) receive a reminder to be screened by a physician; (ii) receive a self-sampling kit; (iii) receive an offer to order a self-sampling kit. Comparisons of the screening attendance among the interventions will be made. To also address potential effects on inequities, the analyses will include comparisons by sociodemographic characteristics. The rates of cervical cancer/precancer among the interventions will also be compared. Further, to assess the feasibility of and the compliance to follow-up after a positive HPV test in this population, half of the HPV-positive women from each self-sampling arm will be referred to initial follow-up by their regular general practitioner (GP), while the other half will be referred to initial follow-up by a gynecologist. The project will be embedded in the national cervical cancer screening program, and will utilize the extensive nationwide registers describing performance and outcomes of screening collected by the Cancer Registry of Norway.
This study aims to assess the therapeutic role of rTMS on parkinson's patients with depression. Thirty PD patients with depression using United Kingdom (UK ) bank criteria for PD will be recruited from outpatient clinic in Assiut University. All patients will be admitted at Neuropsychiatric Department, Assiut University Hospital/ Assiut, Egypt.Each patient fulfilled the inclusion criteria as having score more than or equal 14 on Beck Depression Inventory (BDI) will be recruited. The patients will be allocated randomly into two groups one of which will receive real sessions of high frequency rTMS (25 HZ), with intensity of 80% of resting motor threshold detected from the hand motor area, with total 2000 pulses for left DLPFC for 10 consecutive sessions totally over period of 10 days with repeated booster session every month during the period of follow up among three months. The other will receive sham sessions. All subjects will be followed up by selected clinical rating scales at different intervals pre session, post 10 sessions, and after one, two and three months.
Flumazenil was studied in two trials in 497 patients who were presumed to have taken an overdose of a benzodiazepine, either alone or in combination with a variety of other agents. In these trials, 299 patients were proven to have taken a benzodiazepine as part of the overdose, and 80% of the 148 who received flumazenil responded by an improvement in level of consciousness. Of the patients who responded to flumazenil, 75% responded to a total dose of 1 mg to 3 mg. 

Reversal of sedation was associated with an increased frequency of symptoms of CNS excitation. Of the patients treated with flumazenil, 1% to 3% were treated for agitation or anxiety. Serious side effects were uncommon, but six seizures were observed in 446 patients treated with flumazenil in these studies. Four of these 6 patients had ingested a large dose of cyclic antidepressants, which increased the risk of seizures (see WARNINGS).
A mobile device application for measuring actual wait times experienced by patients of doctors or other medical service providers. A patient launches the application on the mobile device, views available service providers and selects a provider. The patient starts the clock for the selected service provider when the wait begins, and stops the clock when the wait ends. At this time or after the visit, the patient can post their actual wait time, a star-based rating and comments for other patients to view on the application or on a web page equivalent. The patient must be within a GPS-verified geofence around the provider's office in order for the wait time to be considered valid. An integrated real-time messaging application used during surgical procedures is also disclosed.
PROBLEM TO BE SOLVED: To obtain the subject adhesion inhibitor, capable of preventing pathogenic microorganisms of periodontal disease from adhering to the surfaces of teeth by brushing or coating, by allowing a shellac to be included in a dentifrice. SOLUTION: This adhesion inhibitor contains a shellac preferably in 0.5-5 wt.% in a dentifrice. The dentifrice, for example, includes an abrasive, a moistening agent, a foaming agent, a tacky agent, a flavor, a preservative, a medicinal component or the like, and has a form of a get, a paste, a powder, a liquid or a spray. The shellac is a resinous material obtained by purifying the secretion product covering the body of Laccifer lacca. The adhesion inhibitor can be prepared by dissolving the shellac in propylene glycol or the like, and carrying out a process as well as that of the conventional dentifrice.  The surfaces of teeth are coated with the shellac and smoothened by brushing with the adhesion inhibitor and coating the adhesion inhibitor on the surfaces of teeth, and as a result, the adhesion of a leftover food, which becomes a source material for propagation of microorganisms, can be prevented from attaching to the teeth.
<P>PROBLEM TO BE SOLVED: To provide a modified device for implantation for the delivery of the medicine.  <P>SOLUTION: The device for implantation for delivering the medicine comprises a housing and the medicine held in the housing. The orifice mechanism is positioned in the housing and made to communicate with the medicine. The orifice mechanism comprises an inner member having the base end part and the distal end part and a coil wound spirally on the circumference of the inner member. The coil and the inner member defines the first passage for transferring the medicine. An inlet is positioned at the base end part of the coil and an outlet at the distal end part of the coil. The medicine is transferred with the orifice mechanism and discharged from the housing.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Glomerulonephritis occurs in up to one-half of patients with systemic lupus erythematosus (SLE) and is a major cause of morbidity and mortality. Guidelines published by the American College of Rheumatology in 2012 (1) suggested a multi-targeted treatment approach that has been shown to lead to clinical remission in up to one-half of patients (2,3).

However, at least one-third of patients continue to have active disease; many of these individuals may eventually develop renal failure. Therefore, there is an unmet need for more effective therapeutic approaches for lupus nephritis (LN). Although the pathogenesis of LN is almost certainly multifactorial, the presence and persistence of immune complexes are thought to play a major role in disease pathogenesis by attracting inflammatory cells of the innate immune system, such as neutrophils and monocytes, resulting in cell activation and secretion of inflammatory cytokines, including interferon alpha, TGF-beta, IL-1, IL-6, and TNF-alpha (6-7). Pentoxifylline (PTX) is a nonselective phosphodiesterase inhibitor with minimal toxicity. It has been in clinical use since 1972 for treatment of patients with intermittent claudication secondary to peripheral vascular disease. This generic drug has also recently been increasingly used off-label for several other conditions, including patients with diabetic nephropathy, in whom the unexpected finding of significant reduction of proteinuria has been repeatedly demonstrated (34-38). The mechanism of this phenomenon is unclear, although experimental studies in animals and humans have observed suppression of inflammatory cytokine production following PTX administration (24-28). In LN, 2 small, uncontrolled observational studies of PTX reported reduction in proteinuria following 2-6 months of treatment with PTX (8,9). The level and chronicity of proteinuria have long been associated with disease prognosis in patients with LN (10). Thus, a novel treatment that could significantly and persistently reduce or even eliminate proteinuria could result in substantial improvement in the long-term outcome of patients with this most serious manifestation of SLE.
Patient consumes 1 package instant oatmeal for breakfast each day for 1 month. Blood is drawn to assess lipid panels before diet and after 1 month of diet.
AIM: Wide volume scan (WVS) coronary computed tomography angiography (CCTA) enables aortic arch visualization. This study assessed whether the thoracic aortic plaque burden (TAPB) score can predict major cardiovascular adverse events (MACE) in addition to and independently of other obstructive coronary artery disease (CAD) attributes.
METHODS: This study included patients with suspected CAD who underwent CCTA (n=455). CCTA-WVS was used to assess CAD and the prognostic capacity of TAPB scores. Data analysis included the coronary artery calcification score (CACS), CAD status and extent, and TAPB score, calculated as the sum of plaque thickness and plaque angle at five thoracic aortic segments. The primary endpoint was MACE defined as a composite event comprised of ischemic stroke, acute coronary syndrome, and cardiovascular death.
RESULTS: During a mean follow-up period of 2.8±0.9 years, 40 of 455 (8.8%) patients experienced MACE. In the Cox proportional hazards model adjusted for clinical risks (Suita cardiovascular disease risk score), we identified TAPB score (T3) as a predictor of MACE independent of CACS >400 (hazards ratio [HR], 2.91; 95% confidence interval [CI], 1.26-6.72; p=0.012) or obstructive CAD (HR, 2.83; 95% CI, 1.30-6.18; p=0.009). The area under the curve for predicting MACE improved from 0.75 to 0.795 (p value=0.008) when TAPB score was added to CACS >400 and obstructive CAD.
CONCLUSIONS: We found that comprehensive non-invasive evaluation of TAPB and CAD has prognostic value in MACE risk stratification for suspected CAD patients undergoing CCTA.
Embodiments of the disclosure relate to treatments for ringworm on biotic and abiotic surfaces. According to one aspect, a concentrated antimicrobial solution is provided. The concentrated solution includes an antimicrobial composition, a solubilizing agent, and an essential oil. The concentrated antimicrobial solution can be mixed with water, and the resulting solution can be used to disinfect abiotic surfaces from ringworm. According to another aspect, an antimicrobial cream is provided. The antimicrobial cream includes a carrier including a humectant and an antimicrobial composition dispersed in the carrier at 1% w/v or greater.