anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1. Process for the preparation of amlodipine benzenesulphonate of formula (I) characterised by reacting benzenesulphonic acid with phthalamidic acid derivatives of general formula (II): wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium. 2. A process according to claim 1, characterised in that the phthalamidic acid derivative of general formula (II), wherein X is as defined in claim 1-is reacted with at least a stoichiometric amount or with a small excess of benzenesulphonic acid. 3. A process according to claims 1 or 2, characterised in that the reaction was carried out in an inert solvent at an elevated temperature. 4. Phthalamidic acid derivative of general formula (II): wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium. 5. 2-[/2-N-(2-carboxy-benzoyl)-aminoethoxy/methyl]-4-(2-chlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine. 6. Process for the preparation of phthalamidic acid derivatives of general formula (II), wherein X represents hydrogen or alkali metal or alkali earth metal or quaternary ammonium, characterized by reacting 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-(2-phthalimidoethoxy) methyl-1,4-dihydropyridine with a strong base, if desired, reacting the obtained compound of general formula (II), wherein X represents alkali metal or alkali earth metal or quaternary ammonium-with or without isolation with an acid. 7. Process according to claim 6, characterised in that the strong base is alkali metal hydroxide, alkali earth metal oxide or hydroxide, or quaternary ammonium base. 8. Process according to claims 6 or 7, characterised in that the strong base is used in an amount of at least a stoichiometric or a slight excess, and, if desired, neutralized with a stoichiometric amount of acid. 9. Process according to any of claims 6 to 8, characterised in that the reaction with the strong base is carried out at room temperature and the reaction with the acid is carried out during ice-cooling. 10. Process according to claim 1, characterised in that the phthalamidic acid derivative is prepared according to any one of claims 6 to 9.
The objective of this study is to assess the safety, feasibility, and effects of the practice of the Transcendental Meditation technique in adults with migraines. This study will involve 30 female participants recruited from migraine treatment facilities and migraine support groups in the US. The study will span three months, with all participants practicing Transcendental Meditation (TM) while continuing their usual lifestyle and medication regimen. Pre-data will be collected through symptom analysis, headache patterns, and evaluation questionnaires. All potential subjects will keep a daily migraine diary for 30 days before inclusion in the study, both to assess migraine status and to adhere to study protocols during the study. All the subjects will receive TM instruction, followed by bi-weekly group meetings and one-on-one sessions for 3 months to monitor progress and ensure correct practice.
Reagent tablets consisting of adhesive reaents and readily tablettable materials have adhesive reagents forming the middle layer and readily tablettable materials (e.g. NaCl, KCl, sodium benzoate or urea) forming the upper and lower layer of a three-layer tablet. The tablets are produced by compressing the adhesive reagents, opt. with the addn. of further adjuvants, between two layers of readily tablettable substances, pref. on a rotary tabletting machine with three filling and compressing stations. The middle reagent layer of the tablets is stabilised and protected against mechanical damage by the outer layers.
During general anesthesia or for some life-threatening conditions (unconsciousness, respiratory insufficiency), tracheal intubation may be mandatory. Tracheal intubation consists of inserting a tube inside the trachea through the glottis, therefore allowing patients' ventilation and airway protection. However, in some cases, intubation can be difficult with standard method (e.g. direct laryngoscopy) and visualisation of the glottis may be impossible. In those cases, alternative devices may be successful (e.g. videolaryngoscopy, fiberscopy). In cases of failure of alternative devices, prioritization to patients' ventilation is mandatory and supra-glottic devices like laryngeal masks and tubes are designed to allow an adequate ventilation. These devices are present in all difficult intubations algorithms and represent a mandatory alternative. For some specific models, tracheal intubation is possible through some of the supra-glottic devices. It's the case for the ILMA, which remains, despite the fact being more than 20 years old, the Gold Standard. Until now, no other supra-glottic device equals the ILMA concerning blind intubation, which is often necessary in emergency situations or outside the operating room (e.g. out-of-hospital care).

The design and 2016 market release of a new laryngeal tube which equally allows intubation through the device (iLTS-D) and has a gastric access potentially challenges the supremacy of the ILMA. The first two studies concerning the iLTS-D have shown encouraging results. A first study made on manikins showed a similar success rate and time for intubation for the ILMA and iLTS-D, while the insertion of the LTS-D being easier and quicker than the ILMA. A second one has demonstrated a success intubation through the iLTS-D in 29 patients of 30 without any difficult intubation criteria with 2 attempts under fiberoptic control. Concerning ventilation, the iLTS-D doesn't differ of the already well-known LTS-D.
PURPOSE OF REVIEW: Dysbiosis may be a key driver of systemic inflammation, which increases the risk of non-AIDS events in people living with HIV (PLWH). Modulation of the microbiome to reverse this dysbiosis may be a novel approach to decrease inflammation and therefore morbidity and mortality in PLWH.
RECENT FINDINGS: Fecal microbiota transplantation (FMT), probiotics, prebiotics, synbiotics, postbiotics, and dietary modifications have the potential to modulate the microbiome. These interventions have been well tolerated in clinical trials to date. However, these interventions have not resulted in consistent or lasting changes to the microbiome or consistent changes in biomarkers of intestinal permeability, microbial translocation, inflammation, immune activation, or CD4 + T cell counts. Sustained engraftment may require prebiotics and/or dietary modifications added to either probiotics or FMT.
SUMMARY: Adequately powered randomized controlled trials are needed to elucidate whether microbiome modulation can be achieved and impact systemic inflammation in PLWH.
The olive leaf extract silver nanoparticles may be synthesized by extracting olive leaves and using the extract to synthesize AgNPs. Olive leaves may be washed, dried, and ground to a powder. The olive leaf powder may be mixed with a first solvent to form a first olive leaf extract. The first olive leaf extract may then be separated and/or concentrated by centrifugation and filtration to form a filtrate. The filtrate may be evaporated to form a residue. The residue may then be resuspended in ethanol to form a second olive leaf extract. The second olive leaf extract may be mixed with AgNO 3  to form a mixture including the AgNPs.
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as multiorgan hypersensitivity, has occurred with teriflunomide. One fatal case of DRESS that occurred in close temporal association (34 days) with the initiation of teriflunomide treatment has been reported in the postmarketing setting. DRESS typically, although not exclusively, presents with fever, rash, lymphadenopathy and/or facial swelling, in association with other organ system involvement, such as hepatitis, nephritis, hematologic abnormalities, myocarditis, or myositis, sometimes resembling an acute viral infection. Eosinophilia is often present. This disorder is variable in its expression, and other organ systems not noted here may be involved. It is important to note that early manifestations of hypersensitivity (e.g., fever, lymphadenopathy) may be present even though rash is not evident. If such signs or symptoms are present, the patient should be evaluated immediately. Discontinue teriflunomide, unless an alternative etiology for the signs or symptoms is established, and begin an accelerated elimination procedure immediately [see Warnings and Precautions (5.3) ]. In such cases, patients should not be re-exposed to teriflunomide [see Contraindications (4) ].
PURPOSE OF REVIEW: Obesity and eating disorders share common issues related to media use and effects, especially in the USA. Current research increasingly demonstrates that media literacy can address this problem. This narrative review highlights current media literacy-based research for obesity and eating disorder prevention among youth.
RECENT FINDINGS: Current research using media literacy techniques to prevent obesity indicates that these interventions improve nutrition outcomes, improve family communication about food, improve critical thinking about food advertisements, reduce sugar and fat intake, and reduce screen use for parents and youth. In addition, eating disorder research reveals that media literacy techniques lead to higher scores of body satisfaction and self-esteem, with lower scores of perfectionism, thinness, and ideal masculinity. There is a need for media literacy-based interventions to focus on family communication to prevent obesity and eating disorders. Furthermore, there should be more focus on identified levels of prevention and specific clinical outcomes.
Setd8 regulates transcription elongation, mitotic DNA condensation, DNA damage response and replication licensing. Here we show that, in mitogen-stimulated liver-specific Setd8-KO mice, most of the hepatocytes are eliminated by necrosis but a significant number of them survive via entering a stage exhibiting several senescence-related features. Setd8-deficient hepatocytes had enlarged nuclei, chromosomal hyperploidy and nuclear engulfments progressing to the formation of intranuclear vesicles surrounded by nuclear lamina. These vesicles contain glycogen, cytoplasmic proteins and even entire organelles. We term this process "endonucleosis". Intranuclear vesicles are absent in hepatocytes of Setd8/Atg5 knockout mice, suggesting that the process requires the function of the canonical autophagy machinery. Endonucleosis and hyperploidization are temporary, early events in the surviving Setd8-deficient cells. Larger vesicles break down into microvesicles over time and are eventually eliminated. The results reveal sequential events in cells with extensive DNA damage, which function as part of survival mechanisms to prevent necrotic death.
Participants are given IIV4/ Fluzone® and participate for a single year. For children requiring 2 doses of vaccine (vaccine-naïve), a second immunization will be given at Day 28-32 after Dose 1.
Patients who are scheduled for surgical biopsy or tumor resection surgery will be injected at least four hours to up to four days prior to surgery using the CIVO device. Each needle of the CIVO device will deliver up to 8.3 microliters of solution, including a vehicle control (sterile saline) or subtherapeutic microdoses of motolimod, nivolumab, or motolimod combined with nivolumab. Each microdose is simultaneously injected in a columnar fashion through each of 8, 5, or 3 needles (in a device configuration determined by tumor dimensions) into a single solid tumor or effaced metastatic lymph node.
PURPOSE:To allow the primary diagnosis (screening) of a certain diseases, more particularly a diseases accompanying inflammation by measuring the alpha1-acidic glycoprotein in the body fluid of a livestock animal, pet animal or test animal. CONSTITUTION:Ammonium sulfate is added to the refined bovine serum of the bovine alpha1-acidic glycoprotein so as to attain 60% saturation and the precipitate generated after resting for 3 hours is removed; further, the ammonium sulfate is added to the supernatant so as to attain 90% saturation. The alpha1-acidic glycoprotein is obtd. as precipitate after resting of 16 hours. The alpha1-acidic glycoprotein obtd. by ammonium sulfate fractionation is dialized by an acetic acid buffer soln. of 0.02M and pH 4.3 and is processed in a DEAE-cellulose column equilibrated by the same buffer soln. The protein is cleaned with 0.1M buffer soln. and thereafter the alpha1-acidic glycoprotein is obtd. as the fraction eluted by 0.5M buffer soln.
Patients will undergo twice daily adaptation to upward shifts in vision. Participants will be provided with goggles fitted with prismatic lenses that shift vision upward by 25 dioptres (about 17 degrees). While wearing the lenses, participants point to two 10cm-diameter visual targets positioned one above the other (about 20cm apart) on a wall, returning their pointing arm to their chest between each pointing movement. Participants make 50 pointing movements, as fast and as accurately as possible. Such a procedure induces a downward sensorimotor adaptation of pointing movements. Participants undergo this training twice a day (morning and evening) for two weeks in a self-guided fashion.
This study is designed as a randomized, double-blind, placebo-controlled clinical trial, and is planned to be conducted at 3 clinical centers in China from January 1, 2023, to January 31, 2024. During the study period, we intend to enroll a total of 238 eligible patients. These patients will be randomly assigned in a 1:1 ratio to receive either sivelestat sodium or placebo via continuous intravenous infusion (0.2mg/kg/h) over a 24-hour period for 7 days (or to the day of death or ICU discharge if it occurs before day 7). Both the patients and investigators are blinded to the treatment assignment. Subsequent follow-ups will be performed in person at 7,14 and 28 days after randomization. The primary endpoint will be at 7 days post randomization and secondary endpoints will be at 14 and 28 days post randomization. Also, endpoint assessors are masked to the treatment allocation. Lastly, these endpoint variables will be compared between the treatment groups to investigate the efficacy and safety of sivelestat for COVID-19-associated ARDS
The invention discloses a method for preparing high-quality dried momordica grosvenori. The method comprises the following steps: A) performing after-ripening on momordica grosvenori; B) washing the momordica grosvenori and removing water; C) punching; D) ultraviolet disinfection; E) dynamic vacuum microwave drying; F) sealing and packaging. The yellow dried momordica grosvenori produced by the method has bright color like the fresh fruit, so that the stability of natural carotenoid can be ensured, the loss of efficacy and nutrition is greatly reduced; the retention rate of mogroside V is high, and mouthfeel and flavor are close to the fresh fruit. In particular, the sweet taste is pure and cool, and the soaked water is golden yellow and bright. The process is simple and easy to control; the operation process is simple and convenient without repeat; the drying time is short; during the drying process, the method cannot generate toxic and harmful substances; the energy consumption is low. Compared with the normal electrical heating method, the method can save energy for 50% above; compared to the existing microwave drying method, the method can save energy for 40% above. The obtained dried momordica grosvenori is sanitary and clear, low in possibility of getting damp, durable in storage, long in storage time, and good in edible safety.
Cerebral perfusion is critical for the early detection of neurological diseases and for effectively monitoring disease progression and treatment responses. Mouse models are widely used in brain research, often under anesthesia, which can affect vascular physiology. However, the impact of anesthesia on regional cerebral blood volume and flow in mice has not been thoroughly investigated. In this study, we have developed a whole-brain perfusion MRI approach by using a 5-second nitrogen gas stimulus under inhalational anesthetics to induce transient BOLD dynamic susceptibility contrast (DSC). This method proved to be highly sensitive, repeatable within each imaging session, and across four weekly sessions. Relative cerebral blood volumes measured by BOLD DSC agree well with those by contrast agents. Quantitative cerebral blood volume and flow metrics were successfully measured in mice under dexmedetomidine and various isoflurane doses using both total vasculature-sensitive gradient-echo and microvasculature-sensitive spin-echo BOLD MRI. Dexmedetomidine reduces cerebral perfusion, while isoflurane increases cerebral perfusion in a dose-dependent manner.
According to statistics of the American Cancer Society, an estimated 31,000 individuals will be diagnosed with pancreatic cancer and 25,000 will die of the disease, making it the fifth leading cause of U.S. cancer deaths this year despite all current therapy. This protocol attempts to exploit an approach to pancreatic cancer immunotherapy using a naturally occurring barrier to xenotransplantation in humans in an attempt to vaccinate patients against their pancreatic cancer. The expression of the murine alpha (1,3) galactosyltransferase \[alpha (1,3) GT\] gene results in the cell surface expression of alpha (1,3) galactosyl-epitopes (alpha-gal) on membrane glycoproteins and glycolipids. These epitopes are the major target of the hyperacute rejection response that occurs when organs are transplanted from non-primate donor species into man. Human hosts often have pre-existing anti-alpha-gal antibodies that bind alpha-gal epitopes and lead to rapid activation of complement and cell lysis. The pre-existing anti-alpha-gal antibodies found in most individuals are thought to be due to exposure to alpha-gal epitopes that are naturally expressed on normal gut flora leading to chronic immunological stimulation. These antibodies may comprise up to 1% of serum IgG. In this Phase I/II trial, patients with surgically resected pancreatic cancer will undergo a series of twelve intradermal injections with a vaccine composed of irradiated allogeneic pancreatic cancer cell lines (HAPa-1 and HAPa-2) that have been transduced with a recombinant Moloney murine leukemia virus (MoMLV)-based retroviral vector expressing the murine alpha (1,3) GT gene. Endpoints of the study include determination of dose-limiting toxicity (DLT), maximum tolerated dose (MTD), tumor and immunological responses.
The patients in case group will be received baked milk daily in the form of muffin for 6 months. They will be visited weekly in the first month and every 2 weeks in other 5 months. At the end of the 6 months, the patients will undergo oral food challenge by 30 grams baked cheese in the form of pizza cheese. If the test will be negative, they will receive pizza cheese 4 or 7 days per week for other 6 months. The patients will be followed every 2 weeks during this period.
FAO / WHO noted that iron deficiency is still an important nutritional problem. Iron deficiency problem has always been in Taiwan. This study intends to use the products, Natureheme-iron, using blood of pig to concentration, separation and extracted, and then got natural and clean Natureheme-iron. Natureheme-iron is not just a good iron supplement, while also providing an excellent source of natural protein. This is a randomized, double-blind trial, subjects separate to 3 groups, one group (n = 20) take two Natureheme-iron capsules a day for a total of 12 weeks (1000mg Fe / capsule), another group (n = 20) with the same dose of placebo, and the other group (n = 20) is a commercial iron supplement (100mg Fe). Investigators assess whether Natureheme-iron can promote iron absorption and antioxidant effects, and compare the effects with commercial iron supplement. When this study is completed, it will increase the value of Natureheme-iron, and can improve health of Taiwanese.
OBJECTIVE: The aim of our study is to find a better way to identify a group of papillary thyroid carcinoma (PTC) with more aggressive behaviors and to provide a prediction model for lymph node metastasis to assist in clinic practice.
METHODS: Targeted sequencing of DNA/RNA was used to detect genetic alterations. Gene expression level was measured by quantitative real-time PCR, western blotting or immunohistochemistry. CCK8, transwell assay and flow cytometry were used to investigate the effects of concomitant gene alterations in PTC. LASSO-logistics regression algorithm was used to construct a nomogram model integrating radiomic features, mutated genes and clinical characteristics.
RESULTS: 172 high-risk variants and 7 fusion types were detected. The mutation frequencies in BRAF, TERT, RET, ATM and GGT1 were significantly higher in cancer tissues than benign nodules. Gene fusions were detected in 16 samples (2 at the DNA level and 14 at the RNA level). ATM mutation (ATMMUT) was frequently accompanied by BRAFMUT, TERTMUT or gene fusions. ATMMUT alone or ATM co-mutations were significantly positively correlated with lymph node metastasis. Accordingly, ATM knock-down PTC cells bearing BRAFV600E, KRASG12R or CCDC6-RET had higher proliferative ability and more aggressive potency than cells without ATM knock-down in vitro. Furthermore, combining gene alterations and clinical features significantly improved the predictive efficacy for lymph node metastasis of radiomic features, from 71.5 to 87.0%.
CONCLUSIONS: Targeted sequencing of comprehensive genetic alterations in PTC has high prognostic value. These alterations, in combination with clinical and radiomic features, may aid in predicting invasive PTC with higher accuracy.
A prescription for an orthodontic appliance is generated with a method using a computer-based program. The method includes providing a list of orthodontic appliances. From the list, an orthodontist may select an orthodontic appliance using a computer interface. The method also includes depicting a pictorial representation of the orthodontic appliance selected with a representation of the patient's maxillary and mandibular arches and providing a written description of the orthodontic appliance selected. The prescription is then sent to an orthodontic manufacturing lab. In one embodiment, the computer based program is installed on a computer system in an orthodontic clinic. In another embodiment, the computer based program is accessed by connecting to a web site. The web site may be operated by the orthodontic manufacturing lab or the supplier of the computer-based program.