anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND PURPOSE: <p>A prerequisite for the treatment of carotid atherosclerosis is the accurate measurement of the stenosis, that is most commonly evaluated by duplex ultrasonography. In this study, we aimed to verify the reliability of 2D and 3D ultrasonography, comparing the data to results of post-mortem micro-CT examination.</p>.
METHODS: <p>Neurological patients with any life-threatening, presumably fatal neurological disease were enrolled. Ultrasound examinations were performed with a Philips Epiq 5G machine, using a VL13-5 broadband linear volume array transducer. Plaque length, diameter and vessel area reduction (stenosis) were calculated using the 2D images. Finally, the stenosis was reassessed using automatized, 3D application as well. After the death of the patient, autopsy was performed, during which the previously examined carotid artery was removed. The samples were examined with micro-CT. Similar to the ultrasound examination, plaque length, diameter and vessel area reduction (stenosis) were determined.</p>.
RESULTS: <p>Ten vessels of seven patients were eligible for complex comparison. Plaque diameter and length measured by CT did not correlate with the ultrasound data. CT-measured axial plaque and vessel areas showed no correlation with ultrasound results either. While determining the strength of correlation between stenoses measured by the different modalities, significant correlation was found between the results measured by ultrasound (2D) and CT (Pearson r: 0.902, P<0.001).</p>.
CONCLUSION: <p>Three-dimensional ultrasound analysis is a spectacular method for examining carotid plaques, as it can assist in a more detailed evaluation of the plaque morphology and composition, thereby identifying plaques with a particularly high risk of stroke. Micro-CT is an excellent tool for the exact determination of calcified plaque areas, but ultrasound images are not suitable yet for such a precise examination due to acoustic shadowing and artifacts.</p>.
A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric or image cytometry to detect, enumerate and characterize carcinoma cells in the blood. The present invention incorporates the conjugation of different antibodies to the same ferrofluid. This has the effect of making the ferrofluid polyspecific with respect to the antigens that the ferrofluid will bind. The multiple antibodies present on the same ferrofluid do not appear to block or otherwise interfere with each other. Such ferrofluids have the highly desirable effect of being able to bind specifically to more than one type of cell. The assay is especially useful to enable the capture of CTCs that have low EpCAM expression, but high expression of other tumor markers; accordingly, the assay facilitates the biological characterization and staging of carcinoma cells.
PROBLEM TO BE SOLVED: To obtain a stabilizer composition having an improved water solubility, and useful for a medicine and a vciterinary medicine, especially as an anti-ulcer agent. SOLUTION: This stabilizer composition useful for anti-ulcer agent having an improved water solubility contains a benzimidazole-based compound of the formula [A-ring can be substituted; R<b> is H, an alkyl, an acyl, a carbamoyl, an alkoxysulfonyl, etc.; R<c> , R<e> and R<g> are each H, an alkyl, an alkoxy or an alkoxyalkoxy; R<d> is H, an alkyl or the formula-OR<f> ; R<f> is a hydrocarbon; (q) is 0, 1] and a branched cyclodextrin-carboxylic acid or its salt. The composition contains 0.1-20mol of the branched cyclodextrin-carboxylic acid based on 1mol of the compound of the formula.  By using the branched cyclodextrin-carboxylic acid, the stability of the composition is improved and the water solubility of the benzimidazole-based anti-ulcer agent is markedly increased, and since an effect to the living body e.g. an erythrocytolytic action, is small compared with that of β-cyclodextrin, a high safety to the blood is demonstrated. Especially since the decomposition of β-CyD-G2 -COOH, etc., by an acid or a base is extremely little, it has a high safety.
Metastasis lesion will be treated with a SBRT of 50Gy/5F from day 1 to day 5 in a cycle of 21 days.Subcutaneous injection of human recombined granulocyte-macrophage colony stimulating factor (125ug/m² per day) will be executed from day 1 to day 14 in this cycle. Another metastasis lesion will be treated likewise concurrently with rhGM-CSF in a consecutive cycle.
Telomeres are the nucleoprotein complex at chromosome ends essential in genomic stability. Baseline telomere length (TL) is determined by rare and common germline genetic variants but shortens with age and is susceptible to certain environmental exposures. Cellular senescence or apoptosis are normally triggered when telomeres reach a critically short length, but cancer cells overcome these protective mechanisms and continue to divide despite chromosomal instability. Rare germline variants in telomere maintenance genes cause exceedingly short telomeres for age (< 1st percentile) and the telomere biology disorders, which are associated with elevated risks of bone marrow failure, myelodysplastic syndrome, acute myeloid leukemia, and squamous cell carcinoma of the head/neck and anogenital regions. Long telomeres due to rare germline variants in the same or different telomere maintenance genes are associated with elevated risks of other cancers, such as chronic lymphocytic leukemia or sarcoma. Early epidemiology studies of TL in the general population lacked reproducibility but new methods, including creation of a TL polygenic score using common variants, have found longer telomeres associated with excess risks of renal cell carcinoma, glioma, lung cancer, and others. It has become clear that when it comes to TL and cancer etiology, not too short, not too long, but "just right" telomeres are important in minimizing cancer risk.
A model-order reduction method is described for providing a fast fluid flow simulation model of fluid flow in a conduit such as a blood vessel with stenosis. A first method is described for generating a reduced generic numerical model (20) for predicting fluid flow characteristics of fluid flowing through a subject conduit (7'). In steps 11, 12 and 13, geometric and fluid-flow parameter data are derived from CT image scans for each sampled conduit 7 in a reference set. A 3D model is generated 13 for each sampled conduit 7. The geometric parameter data, the 3D model and the fluid flow parameter data are used to generate solutions to fluid dynamics (such as the Navier-Stokes) equations for each sampled conduit 7, and a full order model is created comprising the geometric parameters data, the fluid flow parameter data and the Navier Stokes solutions. A projection-reduction based, for example, on the Proper Orthogonal Decomposition - Discrete Empirical Interpolation Method (POD-DEIM) coupled with an offline/online splitting is used for the reduced-order description of geometric parameters, fluid parameters and fluid dynamic equations. The offline phase defines the constructors of the reduced-order model which are assembled based on the weights of the coefficients (reduced order parameters) identified in the offline phase. A second method is 30 described for using the reduced order model 20 to obtain solutions to Navier Stokes equations for the blood vessel 7' of a new patient (online phase).
Methadone is secreted into human milk. The safety of breast-feeding while taking oral methadone is controversial. At maternal oral doses of 10 to 80 mg/day, methadone concentrations from 50 to 570 mcg/L in milk have been reported, which, in the majority of samples, were lower than maternal serum drug concentrations at steady state. Peak methadone levels in milk occur approximately 4 to 5 hours after an oral dose. Based on an average milk consumption of 150 mL/kg/day, an infant would consume approximately 17.4 mcg/kg/day which is approximately 2 to 3% of the oral maternal dose. Methadone has been detected in very low plasma concentrations in some infants whose mothers were taking methadone. Women on high-dose methadone maintenance, who are already breast-feeding, should be counseled to wean breast-feeding gradually in order to prevent neonatal abstinence syndrome.

Methadone-treated mothers considering nursing an opioid-naive infant should be counseled regarding the presence of methadone in breast milk.

Because of the potential for serious adverse reactions in nursing infants from methadone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. In patients being treated for opioid dependence, this should include weighing the risk of methadone against the risk of maternal illicit drug use.
FIELD: medicine. SUBSTANCE: method involves dilating maxillary alveolar process bone tissue defect in the region of oroantral fistula. Antiseptic treatment combined with low frequency ultrasonic wave irradiation is carried out . Paste layer is applied over the region of removed polyps on the surface of maxilla. Split trapezoidal mucomuscular graft is used to carry out plastic repair. EFFECT: reduced postoperative complications; improved functional results.
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α 1 -antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
1513195 Coated particles with ion exchange properties RHONE - POULENC INDUSTRIES 27 Aug 1976 [28 Aug 1975 28 July 1976] 35774/76 Heading B2E [Also in Division C3] An ion exchange resin which comprises a porous inorganic carrier having a particle size of from 4Ám to 5mm, a specific surface area of 5 to 150m2/g, a pore diameter of 500 to 2500A and a pore volume of 2ml/g which carrier is coated with less than 15mg/m2 of a film of a cross-linked polymer which contains anion-exchanging groups or cation-exchanging groups and having an exchange capacity of less than 2meq/g. The inorganic carrier may be silica or a metal oxide, preferably titanium dioxide or alumina. The cross-linked polymer may result from the polymerisation of at least one epoxy compound in the presence of a polyamine; mixtures of formaldehyde withurea, melamine, a polyamine or a phenol; or mixtures of vinyl monomers, preferably N- vinylpyridine, styrene, 4 - vinylbenzoic acid, acrylic acid and/or methacrylic acid with polyfunctional monomers, preferably monoalkyleneglycol diacrylate, monoalkyleneglycol dimethacrylate, polyalkyleneglycol diacrylate, polyalkyleneglycol dimethacrylate, divinylbenzene, methylene bis(acrylamide), vinyltrihalogensilane, vinyltrialkoxysilane, in the presence of a free-radical initiator or ultraviolet radiation. The anion-exchanging groups may be tertiary amino groups or quaternary ammonium groups, preferably of formula in which each R, which may be the same or different, is an alkyl or hydroxyalkyl group of 1 to 4 carbon atoms and X is an inorganic anion or organic anion. The cation-exchanging groups may be acid functions, preferably carboxylic acid, sulphonic acid or phosphonic acid groups. In the Examples, the inorganic carrier is silica, the polymer is (1) styrene/triethoxysilane which is chloromethylated and reacted with trimethylamine; (5) N, N - bis(2, 3- epoxypropyl) ethylamine / triethylenetetramine, (6) N, N - bis(2, 3 - epoxypropyl) butylamine / triethylenetetramine, (9) acrylic acid / diethyleneglycol dimethacrylate; (10) styrene / vinyltriethoxysilane reacted with sulphonyl chloride.
OBJECTIVES: The aging population, including patients with superficial esophageal cancer, encounters critical dysphagia- and postoperative pneumonia-related issues. Although endoscopic submucosal dissection (ESD) provides advantages over other modalities, older patients are at higher risk of postoperative pneumonia. Furthermore, the etiologies of pneumonia are complex and include patient- (such as sarcopenia) and treatment- (including ESD) related factors. Therefore, this study evaluated swallowing function in patients with superficial esophageal cancer and identified post-ESD pneumonia-associated factors.
METHODS: Comprehensive swallowing function and sarcopenia were evaluated in patients pre-ESD and 2 months post-ESD using high-resolution manometry and several swallowing studies by multiple experts. The effects of mucosal resection and sarcopenia on swallowing function changes post-ESD, the relationship between preoperative swallowing function and sarcopenia, and the factors influencing postoperative pneumonia were investigated.
RESULTS: Twenty patients were included in the study. Patients with preoperative sarcopenia had significantly lower pharyngeal/upper esophageal sphincter and tongue pressures than those without sarcopenia. However, ESD did not worsen pharyngeal or upper esophageal pressure. Post-ESD pneumonia incidence tended to be higher in patients with sarcopenia than in those without sarcopenia. The lower upper esophageal sphincter-integrated relaxation pressure (UES-IRP) was a significant factor in pneumonia development. Furthermore, the receiver operating characteristic curve for UES-IRP in pneumonia yielded an area under the curve of 0.82.
CONCLUSIONS: Sarcopenia is associated with preoperative dysphagia, which increases post-ESD pneumonia risk. Therefore, postoperative pneumonia incidence is expected to increase with an aging population, making preoperative sarcopenia and swallowing function evaluation crucial.
PURPOSE:To obtain a sterilizable hemoglobin adsorbent easy to prepare, by introducing a carboxyl group into the surface of a porous substance. CONSTITUTION:As a method for introducing a carboxyl group into the surface of an adsorbent, there are method for coating the surface of an insoluble carrier with a polymer having a carboxyl group, a method for chemically fixing a compound having a carboxyl group to the surface of the insoluble carrier and a method for forming the adsorbent from the polymer having the carboxyl group. As the carrier to be used, a porous one is pref. and there are porous glass, a porous polyacrylamide gel or the like. As the polymer having the carboxyl group, there are a styrene/maleic copolymer, polyacrylic acid and polymethacrylic acid. In fixing the compound to be fixed, for example, the carrier is irradiated with radiation or ultraviolet rays to be activated and the carboxyl-containing polymer is graft-polymerized. A copolymer obtained by copolymerizing a monomer having a carboxyl group, a crosslinkable monomer and, if necessary, other monomer is molded into a proper shape and subsequently made insoluble by crosslinking reaction.
Participants will be served dinner and a stable isotope of oral \[2H31\] palmitate to measure fat oxidation, at a late dinner time (after DLMO). This arm will then cross-over to Early Dinner as the second metabolic visit.
Anti-oestrogen-based therapies, often combined with a CDK4/6 inhibitor, are the current standard-of-care first-line therapy for patients with advanced-stage hormone receptor-positive (HR+) breast cancer. Resistance to anti-oestrogen agents inevitably occurs, mediated by oestrogen receptor (ER)-dependent or ER-independent mechanisms that drive tumour progression. Emerging endocrine therapies include, but are not limited to, next-generation oral ER degraders and proteolysis targeting chimeras, which might be particularly effective in patients with ESR1-mutant breast cancer. Furthermore, cancers harbouring driver alterations in oncogenic signalling pathways, including AKT and PI3K, might be susceptible to novel combination strategies involving targeted inhibitors. Next-generation CDK2/4 inhibitors are an area of active clinical investigation, and efforts are ongoing to evaluate the role of sequential CDK inhibition. Approved and emerging antibody-drug conjugates exploiting novel target antigens have also demonstrated promising clinical activity. These novel agents, as well as further identification and characterization of predictive biomarkers, will hopefully continue to improve clinical outcomes, reduce the incidence of toxicities, and limit the extent of overtreatment in this population. In this Review, we describe the evolving treatment paradigm for patients with metastatic HR+ breast cancer in light of the growing armamentarium of drugs and biomarkers that will help to shape the future therapeutic landscape. These strategies are expected to involve tumour molecular profiling to enable the delivery of precision medicine.
Open-label, single-center trial. Subjects will recieve intravitreous injections of Macugen 7-14 days before Vitrectomy.
Cranioplasty is the surgical intervention to repair cranial defects. The aim of cranioplasty is not only a cosmetic issue; also, the repair of cranial defects gives relief to psychological drawbacks and increases the social performances. Many different types of materials were used throughout the history of cranioplasty. With the evolving biomedical technology, new materials are available to be used by the surgeons. Although many different materials and techniques had been described, ongoing researches on both biologic and non biologic substitutions continue aiming to develop the ideal reconstruction material.

Autologous bone grafts remain the best option for adult and pediatric patients with viable donor sites and small-to-medium defects. Large defects in the adult population can be reconstructed with titanium mesh and polymethylmethacrylate overlay with or without the use of computer-assisted design and manufacturing customization. Advances in alloplastic materials and custom manufacturing of implants will have an important influence on cranioplasty techniques in the years to come.
The PLEASED intervention arm will receive peer leader who is patients with diabetes that has been gone through our trainings. Also, they will receive three free health screenings (baseline, 3 months, 12 months) and monetary compensation for their time and effort.
The invention discloses a matrix for an external patch and the external patch as well as a mammary gland hyperplasia treating patch prepared from the matrix. The matrix is prepared from all or part of glycerol, ethylenediaminetetraacetic acid, ethylparaben, sodium polyacrylate, crospovidone, far-infrared powder, tartaric acid, sodium carboxymethylcellulose, gelatin, polyvinyl alcohol, a penetrating agent, triethanolamine and purified water. The mammary gland hyperplasia treating patch is prepared from the matrix and a medicinal extract or the matrix. The matrix for the external patch has the functions of relaxing a muscle, driving oxygen and a nutrient in a capillary network to exchange, discharging aged wastes of a fatigue substance, lactic acid and the like, which are accumulated in a body, and removing internal turgescence. The external patch has a certain function of relieving pain. The mammary gland hyperplasia treating patch has the functions of clearing away heat and toxic material, removing turgescence, eliminating stagnation, activating blood circulation to dissipate blood stasis, regulating menstruation, relieving pain, unblocking viscera and inducing the menstruation to relieve menalgia, further, is quick in effect taking, good in curative effect, less in the dosage of the penetrating agent and few in side effects, and can be used for treating various kinds of mammary gland hyperplasia.
Breast cancer patients use Complementary and Alternative Medicine (CAM) in greater proportions than any other group of cancer patients. The primary reason breast cancer patients cite for use of CAM is strengthening the immune system. Healing touch (HT) is a CAM treatment frequently used by cancer patients to reduce adverse side effects of chemotherapy and radiation and to enhance immunity. HT is classified by NIH as a "biofield" therapy as its effects are proposed to be secondary to manipulation of "energy fields" around the body of a patient. A recent meta-analysis has demonstrated relatively large effects of HT on well-being and on physiological parameters, even from brief treatments. However, to date, there are no data on the effects of HT on immune function among breast cancer patients during treatment. This is particularly important as several immune parameters show long-term suppression or alteration, particularly after combined adjuvant chemotherapy and radiation among breast cancer patients. Additionally, there are no data on the effects of HT on the common side effects of breast cancer treatment which can include profound fatigue and radiation-induced skin damage. Physiological mechanisms underlying possible effects of HT are also poorly understood. This study is designed to reduce this knowledge gap by examining how HT affects cellular immune function and biomarkers related to two of the most problematic side effects of breast cancer treatment, fatigue and radiation-induced tissue damage. Effects on the subjective experience of fatigue and clinician rated skin damage will also be noted. Participants will be 42 early stage breast cancer patients who are receiving a standard course of radiotherapy following breast conservation surgery or mastectomy who have either had chemotherapy or not

The significance of the project is as follows. If positive effects are demonstrated on intermediate outcomes such as immune parameters, markers of radiation damage, and/or fatigue, follow-up studies would be warranted examining effects of HT on a) recurrence and survival, b) incidence of long term side effects of radiation, c) quality of life among breast cancer patients. Additionally, if effects of HT are demonstrated, a critical examination of putative mechanisms of action, using controls for effect of attention, expectation, and other placebo effects will be warranted.
Asthma is a chronic obstructive disease that is common in children worldwide. This study aims to examine the effects of a digital game designed for respiratory training in childhood asthma.

Fifteen children aged 8-14 years with asthma were included in the study. There were two groups a digital game group (n=9) and a control group (n=6). Demographic information of the children was recorded. Pulmonary function test (PFT) was evaluated with a portable spirometer (Spirobank MIR), the quality of life of the children was evaluated with the Paediatric Asthma Quality of Life Questionnaire and psychological status was evaluated with the child depression scale. Respiratory training was given to the digital game group with a digital game. The control group was followed with medication. Both groups were evaluated at baseline and after 3 weeks.
Obesity is a heterogeneous condition which results from complex interactions among sex/gender, sociocultural, environmental, and biological factors. Obesity is more prevalent in women in most developed countries, and several clinical and psychological obesity complications show sex-specific patterns. Females differ regarding fat distribution, with males tending to store more visceral fat, which is highly correlated to increased cardiovascular risk. Although women are more likely to be diagnosed with obesity and appear more motivated to lose weight, as confirmed by their greater representation in clinical trials, males show better outcomes in terms of body weight and intra-abdominal fat loss and improvements in the metabolic risk profile. However, only a few relatively recent studies have investigated gender differences in obesity, and sex/gender is rarely considered in the assessment and management of the disease. This review summarizes the evidence of gender differences in obesity prevalence, contributing factors, clinical complications, and psychological challenges. In addition, we explored gender differences in response to obesity treatments in the specific context of new anti-obesity drugs.