anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Although cognitive-behavioral therapy (CBT) is the most effective intervention for pediatric obsessive-compulsive disorder (OCD), many people do not receive CBT initially due, in part, to the lack of trained providers and geographic barriers (e.g., distance to such providers). Rather, the majority of youth with OCD receive psychiatric medication alone or together with unproven forms of psychotherapy. While some serotonergic medications have demonstrated utility in pediatric OCD, side effects can be common, response rates are modest at best, and symptom remission is rare. Storch et al. have shown that CBT can be delivered effectively in an intensive format over a 3-week time-span; however, even this shortened treatment approach involves considerable time and financial expenditure for those who do not have local access to CBT, including three week's time off from work and the cost of local room and board. Given this, more efficient ways of providing CBT need to be identified and tested to increase the number of people with access to this form of treatment. With this in mind, the proposed feasibility study examines the use of videophone technology to evaluate a 5-day cognitive-behavioral intervention for youth with OCD administered at multiple sites. A total of 30 youth will receive 10 60-75-minute sessions of CBT over 5 days (two sessions a day). Cognitive-behavioral therapy will be based on a demonstrated effective treatment protocol, and adapted for administration over a one-week time-span. We will utilize a month-long waitlist control to estimate treatment efficacy. Comprehensive assessments will be conducted by trained clinicians at relevant time-points (i.e., baseline, post-waitlist, post-treatment, follow-up) to assess symptom severity and impairment. Should supporting data be found, CBT delivered in a 5-day format would have the potential to help many more families who would otherwise remain untreated or inadequately treated.
In the active treatment group, participants received 24 consecutive days of active tablets followed by 4 consecutive days of inactive tablets. The active tablet contained 3 mg DRSP (Drospirenone) and 20µg EE (Ethinyl estradiol).
PURPOSE:To obtain a hair-treatment agent effective in suppressing the damage of hair in shampooing, improving the moisture-retainability, smoothing the surface of hair and improving combing smoothness, luster, antistaticity, etc., of hair by compounding a vegetable protein derivative, a cationic surfactant and a silicone compound. CONSTITUTION:The objective agent contains a vegetable protein derivative, a cationic surfactant and a silicone compound. The vegetable protein derivative is a compound of formula I (R1 is various amino acid side chains constituting a peptide deriving a vegetable protein; (n) is 2-30), a compound of formula II (R2 is 7-21C alkyl, 7-21C long-chain alkenyl, etc.; M is H, Na, etc.) or their salts. The cationic surfactant is e.g. stearyltrimethylammonium chloride.
OBJECTIVE: Internal contraction monitoring provides a quantitative assessment of intrauterine resting tone. During the course of labor, elevated intrauterine resting tone may be identified. We hypothesized that elevated intrauterine resting tone could lead to compression of the spiral arteries, thus limiting uterine blood flow and resulting in neonatal compromise. Therefore, our objective was to assess the association between elevated resting tone during labor and neonatal morbidity.
STUDY DESIGN: This was a secondary analysis of a prospective cohort study of singleton deliveries at ≥37 weeks of gestation. Patients with ruptured membranes and an intrauterine pressure catheter in place for at least 30 minutes prior to delivery were included. Intrauterine resting tone was calculated as the average baseline pressure between contractions during the 30 minutes prior to delivery. The study group had elevated intrauterine resting tone, defined as intrauterine resting tone ≥75th percentile (≥12.3 mm Hg). Primary outcome was composite neonatal morbidity: hypoxic-ischemic encephalopathy, hypothermia treatment, intubation, seizures, umbilical arterial pH ≤7.1, oxygen requirement, or death. Secondary outcomes included umbilical artery pH <7.2, lactate ≥4 mmol/L, and rates of neonatal intensive care unit admission.
RESULTS: Of the 8,580 patients in the cohort, 2,210 (25.8%) met the inclusion criteria. The median intrauterine resting tone was 9.7 mm Hg (interquartile range: 7.3-12.3 mm Hg). Elevated resting tone was associated with a shorter median duration of the first stage of labor (10.0 vs. 11.0 hours, p < 0.01) and lower rates of labor induction and oxytocin augmentation (p < 0.01). Neonatal composite morbidity was higher among patients with elevated intrauterine resting tone (5.1 vs. 2.9%, p = 0.01). After adjusting for chorioamnionitis and amnioinfusion, elevated intrauterine resting tone was associated with increased risk of neonatal morbidity (adjusted odds ratio: 1.70, 95% confidence interval: 1.06-2.74).
CONCLUSION: Our findings suggest that elevated intrauterine resting tone is associated with increased risk of neonatal composite morbidity.
KEY POINTS: · Higher intrauterine resting tone is associated with increased risk of neonatal morbidity.. · Elevated intrauterine tone can negatively impact umbilical artery pH and lactate levels.. · If elevated intrauterine pressure is noted, we recommend close monitoring of fetal status..
Introduction. Breast cancer is one of the leading causes of morbidity and mortality in the world.Treatment with hormone therapy reduced the likelihood of tumor recurrence and metastasis in the patient. However, it has adverse effects such as: loss of bone mineral density, increase in body weight, metabolic changes (lipid and low grade systemic inflammation) and, consequently, lower quality of life. Physical training has been used as a means of reducing these and other adverse effects, but there is no definite protocol on which training model is effective, especially in patients who only use Tamoxifen or Aromatase Inhibitor as an adjuvant therapy for treatment of breast cancer.

Objective: To compare the effect of aerobic training on body composition, metabolic and inflammatory variables, physical activity level, sleep, anxiety, depression, body image, fatigue, strength, flexibility and quality of life of women undergoing breast cancer treatment use Tamoxifen and Aromatase Inhibitor and women without cancer.

Method. The sample will be formed by women without cancer and under treatment with hormone therapy being accompanied by the public service for treatment of breast cancer of the city of Presidente Prudente. Where participants will be distributed in six groups submitted to intervention with aerobic training: Tamoxifen group with face-to-face training (GTP); Aromatase Inhibitor Group with face-to-face training (GIP); Tamoxifen training group by distance monitoring (GTA); Training group Aromatase inhibitor by distance monitoring (GIA); Group without training with cancer (GC) and Group training face-to-face without cancer (GTSC). A 24-week notification in which the face-to-face training group will undergo aerobic training three times a week on interspersed days and the group accompanied at a distance will perform as a preferred activity under a distance supervision of professionals every 14 days of return to attend the UNESP for the adequacy of the analysis and selection of attendance to the proposed activities. Evaluations of the variables of interest at the baseline of the intervention will be performed after 12 weeks and soon after the intervention. The investigators will analyze: biomarkers will analyze: biomarkers (Tumor Necrosis Factor-Alpha (TNFα), (LDL), High Density Lipoprotein (HDL), and Very Low Density Lipoprotein (VLDL), as well as in the lipid profile (triglycerides, total cholesterol and low density lipoprotein (LDL) fractions) ), glycemia, insulin, anthropometric measurements, physical activity level, sleep, pain, anxiety, depression, body image, fatigue, strength, flexibility. Trainings will be performed within the target zone of maximum heart rate. Comparisons between groups at each time point will be performed using Student's T-test for independent samples. The comparisons of the variables of interest at the initial moment and after 12 and 24 weeks will be made through the multivariate analysis, where the group effects, time and interaction of both will be compared. All analyzes will be performed in SPSS software version 24.0 and significance of 5%.
The present invention relates to psoriasis resisting capsules and a preparation method thereof. The capsules are oral capsules prepared by extracting effective components of five Chinese medicines of baical skullcap root, rhubarb, giant knotweed rhizome, alkanna tinctoria and liquorice which are taken as raw materials. The present invention has the advantages of safe and reliable medicine application, short course of treatment, high cure rate and no toxic or side effect. The psoriasis resisting capsules have an obvious treatment effect on ordinary psoriasis, blain type psoriasis, erythroderma type psoriasis and articular type psoriasis. No matter how long a person suffering from psoriasis is, the effect can be taken after the person takes the oral capsules for 30 days in general. Meanwhile, the present invention which can reduce hyperlipemia and triglyceride can protect cardiac and cerebral vascular systems. The medicine sources of the psoriasis resisting capsules are easy to obtain, the extraction technology is easy to master, and the industrialized production can be carried out.
Cytokines are commonly deregulated in venous leg ulcers. We have investigated cytokine stability by incubating sterile-filtered wound fluids from chronic venous leg ulcers in vitro. Incubation of wound fluids for 24 h at 37°C decreased IL-1β levels by 88% and TNF-α levels by 64%. IL-1β was degraded by serine proteinases and metalloproteinases while the mechanism for reduced TNF-α remains elusive. The levels of the other peptides did not change significantly (p > 0.05). Normal human dermal fibroblasts exposed to five of the six wound fluids showed increased proliferation with the length of prior incubation using an assay optimised for evaluation of wound fluid bioactivity. Exogenous IL-1β and TNF-α unexpectedly increased (p < 0.001) cell proliferation at concentrations that were measured in the wound fluids. In conclusion, the stability of the eight investigated cytokines in wound fluids differed and presumably the loss of detrimental factors, unlikely IL-1β or TNF-α, resulted in increased fibroblast proliferation.
PURPOSE:To obtain dried Gynostemma pentaphylium Makino having excellent quality without decomposing and losing a saponine ingredient by bringing a raw material of Gynostemma pentaphylium Makino into contact with steam, quickly increasing the temperature of the raw material and deactivating enzyme contained in the raw material. CONSTITUTION:A raw material of Gynostemma pentaphylium Makino selected from a raw foliage and leaf thereof and finely cut material thereof is brought into contact with steam, preferably 100-150 deg.C steam and temperature of the raw material is raised to >=70 deg.C within 10min, preferably 5min to deactivate a saponine decomposing enzyme contained in raw material. When the raw material is continuously treated, the raw material is brought into contact with steam heated to 100-150 deg.C for 1-5min at a ratio of steam of 0.2-1 pts.wt. based on 1 pts.wt. raw material per unit hour. Extract having high saponine content can be inexpensively obtained by the above-mentioned treatment.
EndoSequence BC was injected into the root canals. An EA 25/04 tip was inserted 2 mm beyond the WL and activated for 10 s. Then, the R40 gutta-percha was inserted into the canal and the root canals were filled using SCT.
Alcoholic hepatitis is inflammation of the liver due to alcohol consumption. It can cause one or more of the following symptoms such as jaundice (yellow discoloration of the eyes and skin), pain on the right side of the abdomen, and is accompanied by an enlarged liver. Sepsis is a life-threatening complication of an infection. As the body tries to fight an infection it sends chemicals into the bloodstream. These chemicals that are trying to fight the infection can cause inflammation. This inflammation can cause damage to many body systems and make them fail. Patients with alcoholic hepatitis and sepsis have low levels of Vitamin C in the bloodstream. Vitamin C has been shown to reduce inflammation and organ dysfunction in patients with severe infections.

The investigators do not yet know if Vitamin C will be effective in alcoholic hepatitis. Taking Vitamin C by mouth is not effective as a treatment in people with this condition so participants will receive the Vitamin C intravenously (IV). Participants will be randomly assigned to receive either Vitamin C or a placebo given through an IV every six hours for four days.
The present invention is directed to targeted delivery of a cold slurry underneath a patient's skin to improve the cosmetic appearance of the skin. The “target” tissue can be muscle tissue that when cooled cannot contract and cause wrinkles/lines in the skin to appear. The target tissue can also be adipose tissue that causes overlying tissue to sag and form wrinkles/lines. The cold slurry induces apoptosis, and reduces the size of the tissue, and causes the connective tissue supporting the skin to thicken and tighten, thereby reducing wrinkles/lines. Skin can also be tightened with cold slurry injected into the dermis layer of the skin or within the layers of the oral mucosa making a cold slurry treatment ideal for reducing the appearance of baggy skin after a patient loses weight and or for treating obstructive sleep apnea. Cold slurry can also be used to treat cellulite and acne.
Dihydromocimycin of formula (I) and its salts, esp. alkali, NH3 or amine salts, are new: (I) is prepd. by cultivation of Streptomyces ramocissimus CB CBS 190,60. Also a process for preparing mocimycin (II) which comprises dehydrogenation of (I) with SeO2 is new. (I) is an antibiotic similar in many ways to (II) but does not increase growth rate or improve food utilisation when incorporated in human food or animal feed. (I) can be added to pig feed at 10-200, esp. 20-40 ppm for control of dysentery caused by Treponema (including strains resistant to tylosin). It can also be added to the drinking water or administered by injection.
The invention discloses a drug for treating fatty liver. The drug comprises 10g of haws, 10g of fleece-flower root, 10g of cassia seeds and 10g of wolfberries. A preparation method of the drug comprises weighing the above drugs and mixing the drugs and boiling water. The drug can be used as a tea and be drunk every day. The drug solves the problem that the existing fatty liver treatment drug has large side effects, can cause addiction, has a long treatment period and a high recurrence rate after drug discontinuance and cannot thoroughly treat fatty liver. The drug provided through the invention is suitable for fatty liver treatment.
NEW MATERIAL:A compound expressed by formula I (R<1> is substitutive phenyl; R<2> is substitutive amino; n is 3-10) or a hydroquinone derivative thereof. EXAMPLE:7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid. USE:An antiasthmatic agent, antiallergic agent, remedy for diseases in cardiac, cerebral, renal and circulatory systems, capable of exhibiting improved action and sustained release property with a small amount of the chemical and hardly suffering from inactivating reaction by in vivo metabolism. PREPARATION:A compound expressed by formula II is reacted with a carboxylic acid activating agent, e.g. thionyl chloride, at -10-+50 deg.C to give a reactive derivative at the carboxyl group thereof. The resultant derivative is then reacted with an amino compound expressed by the formula R<2>-H to afford the aimed compound expressed by formula I.
OBJECTIVE: Aim: The aim of the study was to determine the impact of cranioskeletal trauma (CST) on the development of endogenous intoxication syndrome in rats of different ages.
PATIENTS AND METHODS: Materials and Methods: The experiments involved 147 white male Wistar rats of different age groups. The first experimental group included sexual immature rats aged 100-120 days. The second group includes sexually mature rats aged 6-8 months. The third group included old rats aged 19-23 months. In all experimental groups, CST was modelled under thiopentalonatrium anaesthesia. The control rats were only injected with thiopentalonatrium anaesthesia. The animals were withdrawn from the experiments under anaesthesia after 1, 3, 7, 14, 21 and 28 days by total bleeding from the heart. In blood serum, the content of fractions of molecules of middle mass was determined at a wavelength of 254 and 280 nm (MMM254, MMM280).
RESULTS: Results: As a result application of CST in rats of different age groups, an increase in the serum content of MMM254 and MMM280 was observed with a maximum after 14 days and a subsequent decrease by 28 days. At all times of the experiment, the indicators were statistically significantly higher compared to the control groups. The degree of growth of the MMM254 fraction after 1, 7 and 14 days was statistically significantly higher in sexual immature rats, and after 21 and 28 days - in old rats. In old rats after 21 and 28 days of the post-traumatic period, the content and degree of growth of the MMM280 fraction in the blood serum were also significantly higher.
CONCLUSION: Conclusions: Modelling of CST in rats of different age groups is accompanied by the development of endogenous intoxication syndrome, which is manifested by the accumulation of MMM254 and MMM280 fractions in the blood serum with a maximum after 14 days of the experiment. The content of the serum fraction of MMM254 in sexual immature rats in the dynamics of experimental CST exceeds other age groups after 1, 7 and 14 days, in old rats the content of the studied MMM fractions is significantly higher after 21-28 days.
Capsule that is identically appearing with udenafil will be administered to patients in placebo group. For the first 4 weeks, patients will receive 50 mg of placebo drug two times a day, and then the dosage will be doubled to 100 mg two times a day for next 8 weeks.
All the patients received a midluteal long GnRH agonist (GnRH-a) and a gonadotropins (recombinant FSH) stimulation protocol. When the diameter of one or more follicles was ≥ 14 mm, GnRHa (0.05mg/d) was withheld in the study group.
PURPOSE:To obtain a face-cleaning pack simply and readily usable and having excellent face cleaning effect by applying a pack agent obtained by incorporating far-infrared ray-radiating ceramic powder into a viscous liquid containing a chitin material onto a sheet unit. CONSTITUTION:A pack agent obtained by incorporating a far-infrared ray radiating ceramic powder into a viscous liquid containing a chitin material is applied onto a sheet unit made of paper, nonwoven fabric, cloth, etc., and having size capable of covering face. A viscous liquid containing the chitin material is used in order to absorb waste and sweat of skin surface by absorption effect of chitin material and obtained by dissolving the chitin material (e.g. chitosan) in water containing an acid. The ceramic powder is used so as to raise skin temperature by heat insulating effect, promote sweating and discharge waste in a skin together with sweat and is incorporated into a viscous liquid at a weight ratio of 0.1-3 based on the viscous liquid. The resultant pack agent is used by applying to the surface of sheet unit in thickness of about 1mm.
PURPOSE:To obtain a perfume compsn. which emits a long-lasting favorite fragrance without being selective about the note by incorporating specific fragrant substances in a specified combination or in a specified ratio into the compsn. CONSTITUTION:A perfume compsn. contains (-)-muscone, androstenol, and 3-methyl-2-hexenoic acid. Pref. the compsn. contains 0.00001-1wt.% compound perfume which is obtd. by compounding 100 pts.wt. (-)-muscone with 0.2-10 pts.wt. androstenol and 0.002-0.1 pt.wt. 3-methyl-2-hexenoic acid. Since the fragrance inherent in androstenol or 3-methyl-2-hexenoic acid is arranged to have a soft fragrance by the fragrance and retention effects of (-)-muscone, the compsn. can freely be combined with compound perfume compsns. ranging from one having a fragrance with a light touch to one having a heavy dense fragrance, thus giving a wide variety of fragrances.
PURPOSE: A sustained release formulation containing oxycodone is provided to ensure same release rate of conventional sustained release formulation and to simplify process without granulation and drying. CONSTITUTION: A sustained release formulation contains 1-40 weight parts of oxycodone as a main ingredient, 1-60 weight parts of hydroxypropyl cellulose as a sustained release base, and oxycodone containing a pharmaceutically acceptable additive as an active ingredient. The pharmaceutically acceptable additive is an excipient, fluidifier and lubricant. The excipient is starch, gelatinized starch or lactose. The fludifier is cholloidal silicondioxide. The lubricant is stearic acid magnesium or talc. A method for manufacturing the sustained release formulation containing oxycodone: a step of mixing 1-40 weight parts of oxicodon as a main ingredient, 1-60 weight parts of hydroxypropyl cellulose as a sustained release base, and pharmaceutically acceptable additive; and a step of tabletizing.
In the active laser group, participants are treated intravaginally with the fractional microablative CO2 laser system (SmartXIDE2V2LR, MonaLisa Touch, DEKA, Florence, Italy), using the following setting; dot power 30 watt, dwell time 1000 μs, dot spacing 1000 μs and the smart stack parameter from 2 to 3. At the level of the vaginal introitus, the dot power decreases to 20 Watt.
Hair treating compositions in aerosol form comprise a film-forming resin, a solvent therefor and a propellant gas e.g. n-butane, isobutane and halogenated hydrocarbons which may contain 15-20% vinyl chloride.  Numerous vinyl and acrylic resins and cellulose ethers and esters are specified and as solvents these are mentioned ethanol, isopropanol, ethyl acetate CH2Cl2, CH3.CCl3, CFCl2.CF2Cl and water. Hair conditioning agents e.g. fatty ester and silicone oils, fatty quaternary cationic surfactants and lanolin fractions may also be present together with perfumes.ALSO:A hair tress having on its surface a deposit of solvent-softenable resin is set by arranging the tress in the desired way and spraying with a volatile solvent for the resin, which solvent may contain up to 0.25% by weight of dissolved resin.  The dissolved resin may be any conventionally used as a hair fixative, numerous examples being given.
Group 2 will be comprised of twenty male and female adult participants who have never experienced a TBI or concussion to serve as age and gender-matched healthy controls. Participants in Group 2 will have a single visit to measure cerebrovascular reactivity before and after a single dose of sildenafil (50 mg by mouth).
Patients in the control group were infused intravenously with 0.9% Normal Saline (500 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.
Intravenous iron administration in the form of ferric carboxymaltose will be carried out according to summary of product characteristics. Bolus administration (1000 mg) will be followed by an optional administration of 500-1000 mg within the first 4 weeks (up to a total of 2000 mg which is in-label) according to approved dosing rules, followed by administration of 500 mg ferric carboxymaltose at months 4 and 8, except when haemoglobin is \> 16.0 g/dL or ferritin is \> 600 µg/L. To avoid unblinding in these patients a saline infusion will be administered.