anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Organic compounds labeled with no-carrier-added fluorine 18 are processed  yield a compound having a formula in the form of  18  F-R through a nucleophilic substitution reaction. The process has a series of steps. The first step of the process relates to providing an organic compound having a formula of X-R. X is the nucleophilic leaving group in the substitution action, and R is a preferred substituted hydrocarbon structure being selected from aliphatic, alicyclic, heterocyclic aliphatic, carbocyclic and heterocyclic aromatic structures. The X-R compounds with acid hydrogen are excluded. The next step is to bring the organic compound X-R into contact with fluoride ions which are present in a solvent. These fluoride ions are essentially carrier free  18  F ions. The organic compound is brought into contact with the fluoride ions in an apparatus to produce a reaction. The reacting mixture comes into contact during reaction only with surfaces in the apparatus which are made of metals as copper, stainless steel, platinum and Inconel and preferably of glassy carbon. In one embodiment, the reaction takes place at a temperature of between 100° C. and 150° C. in the presence of a basic alkali salt which is contained in a acetamide melt. The reaction may alternately take place in a preferred embodiment, in solution, in a moderately polar, aprotic solvent in the presence of a macrocyclic polyether and an alkali salt at a temperature in the range of 50° C. to 150° C.
The technical scheme of the invention is that: the invention discloses an edible and medicinal liquid used for preventing carsickness. The liquid is prepared from raw materials of, by weight: 15-30 parts of ginger, 10-25 parts of greenish lily bulb, 10-25 parts of jujube, 10-20 parts of spine date seed, 10-20 parts of tuckahoe, 5-15 parts of wrinkled gianthyssop herb, and balance of water. The carsickness-preventing edible and medicinal liquid provided by the invention can be prepared into a beverage or an oral liquid. The invention also provides a preparation method of the carsickness-preventing edible and medicinal liquid. The carsickness-preventing edible and medicinal liquid has functions of adverse qi calming, vomit stopping, tranquilizing, excitement allaying, and immunity improving. The carsickness-preventing edible and medicinal liquid satisfies the requirements of medicines and foods. The beverage has a good mouthfeel, and causes no toxic or side effect. The liquid can be prepared into a beverage or an oral liquid which is easy to carry. When the beverage or the oral liquid is taken, carsickness can be prevented, and thirsty can be quenched.
One Sugar pill capsule will be prescribed twice daily for the first week of the study. For the subsequent 2 weeks, 2 Sugar pill capsules twice a day. The total duration of the treatment will be 3 weeks.
The procedure involved would be the administration of N-acetylcysteine via nebulization, which would be administered to the patient by respiratory therapy in the dosage of 2 mL 20% solution acetylcysteine (or 4 mL of 10% solution) along with inhaled albuterol via endotracheal tube every six hours for 72 hours total. The control arm will have saline administered with the albuterol every six hours. Both arms will have additional bronchodilators administered as indicated clinically (bronchospasm, COPD, peak airway pressure elevation, etc.).
PROBLEM TO BE SOLVED: To obtain the subject composition enabling three-dimensional or raised makeup on the face, ears, nails, etc., by incorporating a thickening agent in a system comprising an aqueous dispersion of a film-forming polymer so as to afford the system with a specific high viscosity level. SOLUTION: This composition is obtained by incorporating an effective amount of a thickening agent in a system comprising an aqueous dispersion of a film-forming polymer particles so as to afford the system with a viscosity of 4.5-100 (esp. 10-45) Pa.s determined at a shear rate of 200 s-1 at 25 deg.C; wherein the film-forming polymer is pref. a radical-polymerized polymer, polycondensate, polymer of natural origin, or a mixture thereof; and the thickening agent is e.g. a cellulose-based one, gum guaiac, xanthan gum, maltodextrin, clay, polyvinylpyrrolidone, linked polyurethane or the like. This composition can also provide a decorative makeup on the skin using a stencil.
Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disorder that causes various symptoms including nasal obstruction, rhinorrhea, olfactory dysfunction, facial pain, and headache . Endoscopic sinus surgery (ESS) is usually recommended for patients who do not response well to conservative treatments. Although surgery is effective to alleviate symptoms and improve the quality of life of CRS patients, a followed long-term postoperative medical treatment is indispensable. Current European and American guidelines recommend glucocorticoids and antibiotics as the primary pharmacotherapeutic approaches for CRS before and after ESS. However, there are a number of CRS patients not responding well to glucocorticoid treatment and conflicting results exist regarding the efficacy of long-term, low-dose macrolide treatment. One potential reason is that CRS is a heterogeneous group of disorders unified by similar clinical presentations and its phenotypes and/or endotypes may be important factors determining the efficacy of treatments.
Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to such an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.
FIELD: biotechnology, helminthology. SUBSTANCE: vaccine is a conjugate of immunostimulating carrier with protective antigen. Protective antigen: protein isolated from connective tissues and showing hyalurosno-lyase activity, its molecular mass is 63000 Da, isoelectric point - at 5.7. Mass ratio of antigen and carrier = 1:(1-10). Vaccine can contain adjuvant, for example, polyaxidonium, muramyldipeptide, aluminium hydroxide. Vaccine is used for prophylaxis and treatment of different helminthiasis forms in human and animals. EFFECT: enhanced effectiveness of vaccine. 3 cl
Injectable Dermal Filler. The same 50 participants received both the treatment device and the control device at the same time (left and right sides of face).
INTRODUCTION: Short Bowel Syndrome (SBS) is a rare gastrointestinal disorder associated with Intestinal Failure (SBS-IF) that leads to morbidity, mortality, and a burden on healthcare costs. Intestine Transplantation (IT) is a treatment option for patients with SBS-IF as it replaces the missing or diseased intestine and offers the potential for return to normal activities and intestinal function. This study aims to describe the clinical course and demographical and clinical characteristics of subjects with SBS-IF who underwent IT in Brazil.
METHODS: This retrospective observational study included all SBS-IF patients who underwent IT in two reference centers in Brazil from April 2011 to December 2021.
RESULTS: A total of 7 young male participants were included in the study. The most frequent underlying condition was surgical complications, followed by intestinal volvulus and incisional hernia. The most frequent indication for IT was a hepatic disease associated with total Parenteral Nutrition (PN). The main type of IT performed was intestine only. The median time from underlying condition to IT was 67.3 (16.5‒88.5) months. The mean (SD) number of yearly hospitalizations per patient was 0.5 (0.3). The most common reason for hospitalization was PN-related complications. Sixty exams were performed in-hospital and 53 in the outpatient setting.
CONCLUSION: The findings of this study may be helpful to understand better the journey of patients with SBS-IF to IT in Brazil, providing real-world evidence to develop health policy guidelines and improve the quality of life of these patients.
The invention discloses a traditional Chinese medicine preparation for treating infantile influenza and a preparation method, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine preparation is prepared from all-grass of alopecurus aequalis Sobol., giantreed juice, all-grass of eulaliopsis binata(Retz.)C. E. Hubb., Japanese polypody rhizomes, herb of klein cinquefoil, herb of savatier monochasma, all-grass of leontopodium forrestianum Hand.-Mazz., leaves of ford nervilia, herb of thunberg's lepisorus, dichotomy forked ferns, wild chrysanthemum flowers, underleaf pearls, roots of conyza japonica (Thunb.) Less., roots of beautifulflower uraria, herb of elodea-like St.John's wort and all-grass of straightstalk alpine meadowrue. According to the traditional Chinese medicine preparation, the compatibility is suitable, complementarity is achieved, the effects of clearing heat, removing dampness, promoting blood circulation to remove meridian obstruction, moistening the lung to arrest cough, checking diarrhea, cooling the blood, stop bleeding, inducing diuresis, reliving pain and the like are achieved, all the medicines are combined to be capable of directly reaching to the lesion location, the traditional Chinese medicine preparation has the advantages of being quick in effect, high in cure rate, free of toxic and side effects, safe and convenient for treating the symptoms of more boogers, low back pain, body pain, abdominal pain, nausea and vomiting, coughing, diarrhea, headaches, fatigue, pharyngalgia and the like caused by the infantile influenza, the price is low, preparation is easy, and the traditional Chinese medicine preparation can be widely applied to clinic treatment of the infantile influenza.
PURPOSE: While pharmacologic therapy remains the cornerstone of lung emphysema treatment, surgery is an additional therapeutic option in selected patient groups with advanced emphysema. The aim of lung volume reduction surgery (LVRS) is to improve lung function, exercise capacity, quality of life and survival. We sought to determine the therapeutic value of surgical resection in specific patients with lung emphysema.
PATIENTS AND METHODS: A retrospective study was performed consisting of 58 patients with lung emphysema who underwent surgical intervention over a 10-year period and were followed for 2 years postoperatively. The clinical characteristics recorded were FEV1 (forced expiratory volume in 1 s), the 6-min walk test (6-MWT), the Modified Medical Research Council (mMRC), body mass index (BMI) and quality of life prior to and 6, 12 and 24 months after surgical intervention. Moreover, all peri- and post-operative complications were noted.
RESULTS: Out of 58 emphysema patients (72% male, FEV1 (L) 2.21 ± 0.17, RV (L) 3.39 ± 0.55), 19 underwent surgical bullectomy, 31 unilateral LVRS and 8 sequential bilateral LVRS. Six months after surgery, there was a statistically significant improvement in FEV1, RV, TLC, 6-MWT and mMRC. Over a period of 12 to 24 months postoperatively, clinical benefit gradually declines most likely due to COPD progression but patients still experienced a significant improvement in FEV1. The most common postoperative complications were persistent air leakage (> 7 days), arrhythmia and subcutaneous emphysema in 60%, 51.6% and 22.4%, respectively. No deaths were observed after surgical intervention.
CONCLUSION: In a selected patient population, surgery led to significant improvement of lung function parameters, exercise capacity and quality of life. Over a period of 12 to 24 months postoperatively, clinical benefit gradually decreased most likely due to COPD progression.
This project will examine 150 detoxified alcohol-dependent patients and 100 age- and gender matched controls. The main aim of this project is to assess 1) which behavioural and neuroimaging alterations (fMRI) associated with reward-based learning (see Projects 1 \& 3) predict relapse within the follow-up period of 6 months, 2) how these interact with clinical and psychosocial factors which can modify the relapse risk, and 3) to provide data for genetic and imaging analyses and modelling. Furthermore, we will explore gender effects on functional imaging parameters of learning. Patients will be detoxified in an inpatient setting and followed for 6 months using the Form 90 and Time-Line Follow-Back Procedure. Clinical assessments, behavioral paradigms of learning, and brain imaging will be carried out within at least 4 half-lives after any psychotropic medication. Subjects will undergo medical management with bimonthly follow-ups and predefined in- and exclusion criteria as described previously. We will implement and apply functional imaging paradigms assessing Pavlovian-to-instrumental transfer and reversal learning as described in Projects 1 and 3. We will associate model parameters of learning with alcohol craving, intake and prospective relapse risk. Independent of these central questions, we will also assess comorbidity, psychosocial and neurobiological disease severity markers to control for specificity of findings.
The present invention relates to a technology and a device for the vacuum concentration of traditional Chinese medicine physic liquor. The physic liquor is added to a circulation loop for being heated, evaporated and concentrated by steam, the inner environment of the circulation loop is in a vacuum state, and the circulation loop is formed by connecting an evaporating pot and a heating pot in a top and bottom mode. The device is connected with the heating pot (14) and an upper connecting pipe (15) of an evaporating pot (9) and is in contact with the evaporating pot in a tangency mode, and the internal diameter of the upper connecting pipe is smaller than that of a cavity (36) on the upper part of the heating pot. A vacuum extraction device (23) is connected behind a condensing device, and a vacuum breaking valve (33) is arranged on the evaporating pot. A liquid transport pipeline (34) used for connecting a liquid feeding pot (1) and the evaporating pot enters a pot body and extends to the lower part of the pot body all the time from a position which is on the upper part of the evaporating pot and is higher than the upper connecting pipe, and an electrical controlled valve (31) is arranged on the pipeline. A level meter is arranged on the evaporating pot, and the level meter and the electrical controlled valve are both connected with a control system. The present invention has high concentration efficiency. The present invention can carry out concentration processing at low temperature, effectively reserve effective components of thermal sensitivity medicine and biologic medicine, and automatically control the whole process of production.
NOTE: CONTAINS BENZYL ALCOHOL (see WARNINGS and PRECAUTIONS: Pediatric Use)

Because of possible physical incompatibilities, DEPO-MEDROL Sterile Aqueous Suspension should not be diluted or mixed with other solutions.

The initial dosage of parenterally administered DEPO-MEDROL will vary from 4 to 120 mg depending on the specific disease entity being treated. However, in certain overwhelming, acute, life-threatening situations, administration in dosages exceeding the usual dosages may be justified and may be in multiples of the oral dosages. 

It Should Be Emphasized that Dosage Requirements Are Variable and Must Be Individualized on the Basis of the Disease Under Treatment and the Response of the Patient. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. Situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation, it may be necessary to increase the dosage of the corticosteroid for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.
Juvenile Idiopathic Arthritis (JIA)is the most common chronic rheumatic disease in childhood. While JIA usually affects the ankle and knee joints, it can also affect hip, cervical spine and shoulder involvement. Secondary problems such as spine involvement or lack of weight transfer may lead to scoliosis. The aim of this study was to perform scoliosis screening in children with JIA and to evaluate families' awareness of scoliosis. aged 4-16 years will include in the study. Trunk rotation measure with scoliometer by applying forward bending test. Children with more than 5 rotations will send to the X-ray. 28 questions will asked, which evaluate the demographic characteristics of children, their educational status, their participation in sports activities, and the physical appearance of families about their children. These questions will asked if the parents had heard of scoliosis before, where they heard it, and whether anyone had scoliosis in the family. Families who complained of posture disorder will asked which shoulder is high without looking at their children and whether they see any height when they leaned forward and the pain situation in their children. Statistical analysis of the data using the SPSS 24.0 (Statistical Package for Social Sciences) program. In all analyzes, p≤0.05 consider statistically significant.
It is a multicentric Tunisian observatory for COVID-19 patients. Confirmed COVID-19 patients, treated on an outpatient basis, in containment centers or hospitalized in COVID-19 units were included retrospectively from March 2020 and had continued prospectively til June 2022. The study had selected eligible patient recorded for inclusion by free practice physicians and hospital physicians. General data, medical history, epidemiological characteristics, clinical examination, biological assessment (blood glucose, NFS, CRP, D-dimer, etc.), clinical course and complications were therefore recorded in a structured and anonymized database. Data collection was carried out by DACIMA Clinical Suite® solution, in accordance with the normative and regulatory provisions in force in the management of health data.
PURPOSE: Postmastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and improves overall survival (OS) in patients with breast cancer. Young age has been recognized as a risk factor for LRR. The primary objective of this study was to determine if recommendations for PMRT differed among patients younger than 50 years as compared to women aged 50 years or older.
METHODS: We reviewed medical records of patients with breast cancer who underwent mastectomy with or without PMRT from 2010 through 2018. Univariable and multivariable models were used to estimate the association of age with PMRT.
RESULTS: Of 2471 patients, 839 (34%) were <50 years; 1632 (66%) were ≥50 years. Patients <50 years had a higher percentage of grade 3 tumors, hormone receptor (HR) negative and/or Her-2/neu positive tumors, clinical stage T2/T3 tumors, and nodal involvement. Compared with patients ≥50 years, patients <50 years were more likely to undergo PMRT (OR 1.57; P = .001) and regional node irradiation (RNI) to the internal mammary nodes. Advanced clinical and pathologic stage, invasive tumor histology, the presence of lymphovascular invasion, and treatment with systemic chemotherapy were predictors of PMRT receipt for patients <50 years (P < .05). PMRT was associated with improved OS and recurrence free survival (RFS) among all patients (P < .01).
CONCLUSION: Patients <50 years were more likely to undergo PMRT and to receive RNI to the internal mammary nodes but were also more likely to have other risk factors for recurrence that would warrant a PMRT recommendation. PMRT improved OS and RFS for all patients.
In the operating room, as part of the open heart surgery, the surgeon will stimulate the superior right atrium section of the heart with a pacemaker for 30 seconds just prior to starting the heart and lung bypass machine. The stimulation is done to see how sensitive the heart is to developing atrial fibrillation. This test result will be documented. The procedure will only take 60 seconds out of the entire operation. It does not involve taking any samples of tissue or blood. Following this step, if the heart demonstrates atrial fibrillation for at least 30 seconds then the participant will then be randomized to either receive the prophylactic drug treatment using Amiodarone or to no prophylactic drug administration. The participant has a 50% chance of receiving the FDA approved study drug Amiodarone. The study arms consist of prophylactic drug administration with Amiodarone, No prophylactic drug administration, or no atrial fibrillation reaction after stimulation with the pacemaker. The remainder of the surgical procedure will not be affected, and will follow routine surgical practice.
The invention belongs to the field of traditional Chinese medicine formulae and particularly relates to a medicine for treating infantile malnutrition. The medicine for treating infantile malnutrition is prepared from the following raw medicinal materials by weight: 50-70g of rhizoma atractylodis, 50-70g of bighead atractylodes rhizome, 50-70g of trigone, 50-70g of poria, 8-12g of dragon blood, 8-12g of cinnabar, 8-12g of realgar, 10-14g of vermilion and 25-35g of massa medicata fermentata fujianensis. The traditional Chinese medicine provided by the invention ha the advantages of being simple in formula, low in price, short in treatment course, good in curative effect, high in cure rate and the like. By adopting the medicinal components, the medicine provided by the invention has the functions of removing food retention and eliminating stagnancy, transporting spleen and stomach and quickly recovering the functions of internal organs. The medicine for treating infantile malnutrition is effective within 5-8 days commonly and is capable of treating both symptoms and root causes. In addition, the raw materials are low in price, so that the medicine is very suitable for treating the general public.