anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide an excellent therapeutic agent for hepatic diseases due to the inhibition of the development of portal venous invasion (PVI).  <P>SOLUTION: The excellent therapeutic and prophylactic agent for hepatic diseases comprises menatetrenone as an active ingredient. The therapeutic and prophylactic agent is especially effective for des-γ-carboxy prothrombin (DCP)-positive hepatic cancer. The therapeutic and prophylactic agent is an inhibitor of the development of the portal venous invasion (PVI) and has remarkable effects on amelioration for prognosis after treating hepatic cancer. Furthermore, the therapeutic and prophylactic agent has excellent effects even as an inhibitor of relapse of the hepatic caner.  <P>COPYRIGHT: (C)2004,JPO
Patients in both cohorts will receive a total of 3 cycles of neoadjuvant combination chemotherapy of nab-paclitaxel and gemcitabine, followed by re-staging CT scan, if re-staging CT does not show evidence of metastatic disease. Patients will receive SBRT and definitive surgical resection. Subsequently, patients will receive 3 cycles of adjuvant combination chemotherapy of nab-paclitaxel and gemcitabine. Each cycle of combination chemotherapy will be a total of 4 weeks. Patients will be evaluated for response at completion of the 3 cycles of neoadjuvant combination chemotherapy with CT scans of chest, abdomen and pelvis. Patients will undergo surveillance CT scan at 3-month intervals until evidence of disease progression.
PROBLEM TO BE SOLVED: To obtain the subject particles capable of being suspended in an aqueous medium in a short time by dispersing an inorganic antiacid, a sugar alcohol and a disintegrating agent and subsequently spray-drying the suspension. SOLUTION: The particles are obtained by homogeneously dispersing an inorganic antiacid (e.g. aluminum hydroxide gel), a sugar alcohol (e.g. mannitol) and a disintegrating agent (e.g. dextrin) in an aqueous medium, and subsequently spray-drying the dispersion. The inorganic antiacid, the sugar alcohol and the disintegrating agent and compounded in amounts of 50-95wt.%, 1-35wt.% and 1-15wt.%, respectively, based on the whole weight of the particles. The particles have large hardness, are hardly pulverized, are easy in storage, can rapidly be dispersed in water, and give mild and non-rough mount touch, since the particles are fine. The particles are convenient for carriage, can rapidly and homogeneously be dispersed and suspended in an aqueous medium, and can orally be administered without giving any uncomfortable touch.  The particles are useful for improving the syndromes of digestion acceleration, indigestion, anorexia, gluttony, dull feelings in stomachs, pyrosis, feelings of fullness in stomach and abdomen parts due to indigestion, stomach ache, gastric hyperacidity, etc.
1352125 Antigenic extracts WELLCOME FOUNDATION Ltd 30 June 1971 [16 July 1970] 34457/70 Heading A5B A proteinaceous non-agglutinogenic material, immunogenic in respect of infections of virulent Brucella spp., and free from lipopolysaccharides and formyl groups, is produced by extracting the live bacterial cells of a non- agglutinating strain of a species of the genus Brucella, e.g. Brucella abortus, such as a rough variant of Brucella abortus strain 45/20, in aqueous suspension with a surfactant agent, adding a water-miscible organic solvent to precipitate the extract, e.g. an alkanol having 1 to 3 carbon atoms, acetone, dioxane, and members of the Cellosolve (Trade Mark) and Carbitol (Trade Mark) families, and separating the proteinaceous precipitate from the other materials in the suspension preferably by centrifugation. The surfactant is preferably an anionic surfactant such as an alkali metal (e.g. sodium) salt of dodecyl sulphate. The live cells may be treated with an anionic surfactant at room temperature for 17 to 24 hours. Sterile injectable vaccine preparations comprise the proteinaceous, non-agglutinogenic material and a pharmaceutically acceptable solid or liquid carrier and optionally an aluminium or potash alum adjuvant. The preparation may be freezedried.
[GB1352125A]
A subset of healthy control participants were matched specifically to participants in Panel E and receive a single dose of MK-7655 125 mg + PRIMAXIN® 250 mg IV in Part 1. In Part 2, participants receive an oral cocktail containing caffeine 200 mg, midazolam 2 mg, and omeprazole 40 mg.
PURPOSE:To produce the mycelia of MANNENTAKE (Fomes japonicus, a kind of fungi) (a health food) containing the component resembling close to that of the natural MANNENTAKE, in a short time and high yield, at a low cost, by culturing seed mycelia in a liquid medium containing glucose and wheat embryo as essential components at specific ratios. CONSTITUTION:A mineral component such as the salt of P, Mn, Mg, Ca, Fe, etc. and a nutrient component such as embryo of cereals, rice bran, etc. are added to sterilized water, stirred and dissolved to obtain a liquid medium. The medium is added with 0.2-10W/V% glucose and 0.2-2W/V% wheat embryo, sterilized usually at 120-130 deg.C for 15-30min, inoculated with the seed mycelia of MANNENTAKE, and cultured under aerobic condition. The amoutn of the seed mycelia to be added to the medium is as low as 5-10mg per 100ml of the medium, and the cultivation is carried out at 25-30 deg.C under agitation at 200-300r.p.m. under aeration of 0.5-3.0V.V.m. for 7-21 days in a dark place. The mycelia of MANNENTAKE containing the components close to the components of the natural fruiting body of MANNENTAKE can be produced by this process in high yield.
The Probabilistic Reward Task (PRT) is a laboratory-based technique used to objectively quantify responsivity to reward. The PRT was initially designed to identify reinforcement learning deficits in clinical populations and subsequently was reverse-translated for use in preclinical studies with rats and monkeys. In this task, subjects make visual discriminations and asymmetric probabilistic contingencies are arranged such that correct responses to one stimulus (rich) are reinforced more often than correct responses to the other (lean). Numerous studies have demonstrated that healthy subjects reliably develop a response bias toward the richly rewarded stimulus, whereas humans with anhedonia and laboratory animals with a history of chronic stress exhibit a blunted response bias. This is important because anhedonia, the loss of responsivity to previously rewarding stimuli, is a behavioral phenotype that is a cardinal feature of multiple neuropsychiatric conditions and is without approved pharmacotherapeutic options. To aid in addressing this critical treatment gap, this report describes validation of the first PRT designed for mice, which are a commonly utilized species in preclinical research toward neuropsychiatric medications development. Results reveal orderly psychophysical functions in response to asymmetric probabilistic contingencies in mice, with signal detection outcomes comparable to previous PRT findings in humans, rats, and monkeys. Taken together, such robust cross-species continuity in task performance confirms that the mouse is well-positioned to serve in bidirectional research efforts between human and animal laboratories. These efforts may accelerate the development of treatment options for anhedonia in the different neuropsychiatric conditions in which it is prominent.
It is often said that the structural damage due to glaucoma precedes functional loss, it is not always clear in its interpretation. To define, which test shows up the earliest sign of glaucomatous damage would be difficult to predict, since the outcome can be influenced by many factors, such as the sensitivity of the test, inter - individual difference or the stage of the disease process itself. Studies on post-mortem retinal ganglion cells counts and SAP field loss in humans and monkeys lead to an observation that, on an average about 25% retinal ganglion cells loss leads to development of an afferent pupillary defect, 35% loss for visual field defects and 40% loss leads to worsening of visual acuity. It would be safe to state that a) the most important clinical challenge is early detection of glaucomatous damage and progression over a period of time; b) Both structural and functional tests are important in assessing early damage and progression; c) significant damage to the retinal ganglion cells can occur before standard tests detect a functional loss in vision. These have paved the way to the development of many studies on the structure - function correlation and stating linear models for the same. However these studies present a dilemma; is the structure - function relation on glaucoma, a statistical statement (a structural measure will reach significance before a functional test) or relational statement (statistical correlation between the structural and functional tests).

We propose to evaluate the structure - function correlation in early and moderate open - angle glaucoma by assessing the retinal nerve fibre layer thickness by Spectral Domain Optical Coherence Tomography and areas of decreased visual field sensitivity given by Humphrey 24 - 2 Swedish Interactive Threshold Algorithm Standard protocol of automated perimetry and determine any representational or statistical significance, if any between the two tests.
Many of the previous studies on medial patellofemoral ligament (MPFL) reconstruction for patellar instability have been difficult to interpret, either because the study setting has included both first-time and recurrent dislocations, or because a lack of control group. Moreover, several studies have enrolled patients with a wide age range, and the majority of the studies have employed retrospective and nonrandomized study designs. Therefore the investigators designed a prospective, randomized study with the primary goal to compare the outcome after MPFL reconstruction with medial reefing for chronic patellar instability. The distance between tibial tubercle and trochlear groove is measured on MRI and corrected if it exceeds 17mm. Primary outcome measure is the occurrence of recurrent objective and subjective patellar instability. The second goal is to evaluate the development of articular cartilage lesions within the patellofemoral joint, and assess clinical scores.
Good bowel cleanout before colonoscopy is commonly associated with significant discomfort that children do not tolerate well. Many pediatric centers in North America use Poly-Ethylene Glycol and electrolyte solution (PEG-ELS, Golytely®) for bowel lavage administered in a large volume, often causing nausea, vomiting and bloating. This is often poorly tolerated by children who usually require the insertion of a nasogastric tube and a day admission. Recently, Pico-Salax was approved in Canada for bowel cleanout in children. It is administered in two divided doses, each in one cup of water; it is palatable and does not have to be given in hospital. However, no controlled study in children compared it with the current standard of care. Our preliminary experience and previous literature suggest that it is effective and well tolerated. We propose to study whether colon cleanout for colonoscopy with Pico-Salax is better tolerated than Golytely in children, by a single blinded randomized controlled trial. Positive results of this study will facilitate a better tolerated regimen for bowel clean out in children.
BACKGROUND: Hepatitis B virus infection is the most common cause of chronic hepatitis. Vertical transmission is the main transmission route of this virus. Current prevention involves giving newborns immune prophylaxis within 12 hours of birth. However, there is still a failure of immunoprophylaxis, especially in cases of mothers who have a high viral load or are HBeAg positive. Tenofovir disoproxil fumarate (TDF) is the first-line treatment for chronic hepatitis B and is known to reduce perinatal HBV transmission. This study aims to determine the efficacy of TDF in preventing vertical transmission in pregnant women with chronic hepatitis B.
METHODS: A literature search was performed on the online databases of PubMed/MEDLINE, Embase, Scopus, Cochrane, and ScienceDirect. The inclusion criteria used were pregnant women with chronic hepatitis B and using TDF antiviral as a transmission prevention therapy with the study design used in the form of a meta-analysis, systematic review, randomized or nonrandomized controlled trial. The outcome of interest was the vertical transmission rate of hepatitis B.
RESULTS: There are two studies used with a meta-analysis study design and a nonrandomized controlled trial with a good critical review result of Validity, Importance, and Applicability. TDF significantly prevented vertical transmission of hepatitis B compared to placebo. In addition, TDF was not associated with the incidence of maternal and fetal complications.
CONCLUSION: TDF has high effectiveness in preventing vertical transmission of hepatitis B and is safe to give to pregnant women.
A  preparation for the  treatment of  : Psoriasis, psoriatiform Dermatosis,  Seborreic   dermatitis,  dry  lichenified   Eczemas, Nevrodermites, pruritis, chronic dermatitis and any inflammatory skin disease. It may help in fungus, and dandruff.  It is  particularly adapted to  the treatment of  psoriasis and any  skin  disease,  very  dry,  rough,   and  with  unattractive scaliness.  This product can avoid recurrences of acute exacerbations of skin diseases.  It can be used on the scalp, including post auricular regions, and remove thick scalp plaques, difficult to treat. It is also effective as ear drops.  It can serve also for cleansing, soothing, softening and moisturizing the skin.  This medicament is basically comprising a mixture of : 1 - Absolute Jasmin Oil. 2 - A hypertonic water solution of Sodium chloride. 3 - Salicylic Acid, in a 4 - Colloidal silica carrier. 5 - Antiseptic Agent.          The first three ( 3 ) ingredients represent the active element of this product. Absolute Jasmin oil in a concentration of 33 to 50 %. Salted Water is added, with a hypertonic concentration of   Sodium  chloride,   much  higher   than  the   physiological concentration of Sodium chloride in the human blood. Salicylic Acid, Colloidal Silica, and Antiseptic material are also included.          The composition is applied and frictioned gently and should be applied only after bathing. It also provides a refreshing and soothing effect. It can be used also as a cosmetic. The form is an emulsion, a liquid cream, or a cream.
After the surgical procedure was completed in patients who underwent general anesthesia, the necessary sterility was provided for the ESPB procedure while the patient was in the lateral position. 1mg/kg 0.5% bupivacaine + 1mg/kg 2% lidocaine was drawn into the same syringe and the volume was completed to 20 ml with normal saline. A linear 10-18 MHz USG probe was placed at the thoracic 7 level (Esaote MyLab 30, Geneva, Italy) in the paramedian plane between two transverse processes. The prepared local anesthetic drug was administered under the guidance of USG.
PROBLEM TO BE SOLVED: To provide a data output device, method, and program with which both an overview of an important point in medical treatment and a detailed change of time series data at the point can be easily grasped.SOLUTION: A data distribution server 11 receives a distribution request from a client terminal 12 and creates and displays a data display screen 15 on the client terminal 12. The data display screen 15 has first and second display areas 41 and 42. In the first display area 41, time series data TS showing changes in conditions of a patient and the details of medical treatment given to the patient is displayed in a graph. A first label 56 can be given to the graph. A second label 57 is displayed at a corresponding position in the second display area W2 temporally corresponding to a specified position in the first display area 41 to which the first label 56 is given. A second time axis 49 of the second display area W2 has a longer time scale than that of a first time axis 47 of the first display area W1.
PURPOSE:The titled rodlike cosmetic, consisting essentially of a wax and a specific component in combination, capable of exhibiting improved preventing effect on blotting of a lipstick by applying to the lips before coating the lipstick and capable of being simply coated and applied to the lips in the same way as the lipstick. CONSTITUTION:A cosmetic for preventing blotting of a lipstick consisting essentially of >=20wt%, normally 20-40wt% based on the total cosmetic, wax, 3-20wt%, based on the total cosmetic, almost truly spherical powder having 5-15mu average particle diameter and 3-75wt%, based on the total cosmetic, diester of malic acid. The above-mentioned cosmetic can be produced by melting and mixing the above-mentioned essential components, putting the resultant mixing in a mold and cooling the mixture according to the conventional method. Seresin, carnauba wax, solid paraffin, candelilla wax, ec., may be cited as the wax, and they may be used alone or two or more may be used together. Nylon powder, polyethylene powder, etc., may be cited as the almost truly spherical powder and they may be used alone or two or more nay be used together. Diisostearyl malate, etc., may be cited as the diester of the malic acid, and the diester may be used alone or combined.
Infections remain one of the major complications during induction therapy of acute myelocytic leukemia (AML). Previous studies have shown that the variation of gut microbiota was an effective predictor for infection development of AML during induction therapy. A growing number of patients with AML received bcl-2 inhibitor-based targeted induction therapy. The investigators assume that there are different effects of bcl-2 inhibitor-based induction therapy on gut microbiota compared with standard intensive chemotherapy (7+3 regimen). Metagenomic Next-Generation Sequencing (mNGS) will be used to perform the investigation of gut microbiota in AML receiving two different induction therapies. And the relationships of gut microbiota with infection complication will be analyzed.
Spinal cord astrocytes are activated in chronic pain models, especially under conditions of prolonged pain. Hence, targeting spinal cord astrocytes for the development of useful analgesics has attracted much attention. In the CNS, connexin43 (Cx43), a membrane protein expressed and functioning exclusively in astrocytes, is well known to be involved in intercellular signaling as a component of gap junction, but also interacts with intracellular molecules via its characteristically long C-terminal region, thereby affecting cellular function. Previously, we found that Cx43 expression was markedly reduced in spinal dorsal horn astrocytes from a mouse model of neuropathic pain. In order to investigate the relationship between reduced Cx43 expression in spinal astrocytes and the onset of pain, we showed that reduced Cx43 expression altered the expression of pain-related molecules such as the glutamate transporter GLT-1 and the pro-inflammatory cytokine interleukin-6 (IL-6). In particular, we focused on the regulation of IL-6 expression by reduced Cx43 expression in both in vivo and in vitro analyses, and found that IL-6 expression is increased through the Akt- glycogen synthase kinase-3β (GSK-3β) signaling system driven by reduced Cx43 expression during neuropathic pain, which in turn triggers pain. These findings suggest that astrocyte Cx43 is involved in pain prolongation by regulating gene expression of nociceptive factors through interactions with intracellular signaling molecules, which is different from its previously known function, and thus raises expectations for its potential as a new drug target for chronic pain.
We will recruit a diverse range of participants to take part and therefore have a limited inclusion/exclusion criteria. Participants must be over 18 years old and be able to a computer/mobile device to access the survey or video conference software (Zoom, as used by the Centre of Ethnic Health Research). Participants can come from a range of cultural communities and religious groups. Participants do not need to have any prior knowledge to participate in the virtual focus groups or the survey.
The Sham (Low Resistance) training regimen will use the same methods described above for the Standard IMT, except for the amount of resistance applied within the device. Subjects will receive a Threshold which has been set to its minimal resistance, which is 9 cmH2O. Again, subjects will be instructed to perform up to 36 breaths daily using the device within a 30-minute period.
The invention comprises a cyanoethyl ether of substantially ungelatinized starch in which only the surface of the starch granule is cyanoethylated.  The novel product may be obtained by treating an aqueous alkaline slurry of ungelatinized starch granules at a pH not exceeding 13 with acrylonitrile and discontinuing such treatment before appreciable gelatinization of the starch granules occurs.  The reaction conditions must be carefully controlled.  Sufficient water is used so that the starch-water slurry has a workable fluidity. While any strong alkali may be used to render the reaction mixture alkaline, it is preferred to use the quaternary ammonium hydroxides, or alkali metal hydroxides such as sodium and potassium hydroxides, in solutions containing less than 1 per cent by weight of the alkali metal hydroxide.  An excess of acrylonitrile is preferred, but preferably less than 3 mols. of acrylonitrile are used for each glucose unit in the starch.  It is desirable to regulate the amount of water and acrylonitrile in the reaction mixture so that the acrylonitrile is present slightly in excess of its solubility in the water present at the reaction temperature.  The temperature is preferably below 40 DEG  C. and may be as low as 0 DEG  C.  The time of reaction must be correlated with the alkalinity and the temperature.  Thus, at pH 12.5 and 35 DEG  C., gelatinization will begin if the reaction time exceeds 30 minutes.  Any type of starch, such as corn, sago, tapioca, potato, wheat and rice starches, may be utilized.  Surface-cyanoethylated starch granules having a degree of substitution of less than about 0.05 cyanoethyl groups per glucose unit are particularly useful in medicinal dusting powders (see Group VI).  In an example, raw corn starch is slurried in water with the addition of sodium hydroxide to give a pH below 13, acrylonitrile is added and the mixture stirred sufficiently to maintain a smooth slurry for 25 minutes at 35 DEG  C., after which time acetic acid is added and the cyanoethylated starch is filtered off, washed and dried.ALSO:A medicinal dusting powder comprises a mixture of 98 per cent by weight of surface cyanoethylated corn starch (for preparation see Group IV (a)) and 2 per cent by weight of magnesium oxide.