anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Methods for modulating the levels of glucagon and blood glucose of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA/kainate receptors is administered to a host. The subject methods find use in applications where it is desired to increase one or both of the glucagon and blood glucose levels in a mammalian host. The subject methods find use in applications where it is desired to decrease the size, or breadth, of the circadian range of blood glucose levels in a mammalian host. The subject methods also find use in applications where it is desired to decrease the frequency, severity, or occurrence of hypoglycemia in a mammalian host. Finally, the subject method finds use in applications where it is desired to decrease the frequency, severity, or occurrence of nocturnal hypoglycemia in a mammalian host, particularly that which occurs in diabetics as a result of therapy with insulins or insulin analogs or other glucose lowering agents, or combinations of such agents.
Endotracheal intubation(ETI) has been considered to be the best method of airway management during cardiopulmonary resuscitation(CPR). However, ETI during CPR requires high skill and experience. Therefore ETI during CPR should be performed by expert in ETI. But the definition of experts in ETI during CPR has not been done yet.

This study tried to estimate the appropriate number of ETI experience for successful ETI at first attempt during cardiopulmonary resuscitation. So the investigators analyze the success rate, speed, trial number, incidence of complications, and hands-off time of ETI using direct laryngoscopy (DL) which is standard device, in real clinical setting. In addition, this study analyze the residency training term, total number of ETI experience using DL at that time.
Preliminary evidence suggests that there are significant associations between bullying and chronic pain, as well as between the quality of peer relationships and psychological function in youth with chronic pain. However, these findings have yet to be replicated, and the role that bullying plays in anxiety in children and adolescents with chronic pain has not yet been examined. This study sought to expand our understanding of the associations between measures of bullying and quality of peer relationships and pain-related function domains in a community sample of schoolchildren with chronic pain. One thousand one hundred fifteen schoolchildren participated in this study; 57% were girls, the mean age of the study sample was 11.67 years (SD = 2.47), and 46% reported having chronic pain. Participants completed measures of pain characteristics, pain interference, anxiety, and depressive symptoms, bullying (past and current), and quality of peer relationships. Youth with chronic pain reported a significantly higher percentage of being bullied in the past compared with youth without chronic pain. In the group of youth with chronic pain, the measures of past and current bullying, and quality of peer relationships, were not significantly associated with pain intensity, pain interference, or anxiety. However, having a history of being bullied and the quality of peer relationships were significantly associated with depressive symptom severity. The findings indicate that research to evaluate the potential causal role of bullying and the quality of peer relationships on pain-related function domains in youth with chronic pain is warranted.
Control cases were visited and their infants were weighed 4 times over one year period. After one year, mothers were provided Philani nutrition intervention program.
PURPOSE: A composition containing bamboo sprout and bamboo leaf extract for removing hangover is provided to be used as a functional beverage. CONSTITUTION: A composition for removing hangover contains bamboo sprout and bamboo leaf extract as an active ingredient. The bamboo sprout extract is obtained using water, ethanol, or mixture thereof. The bamboo leaf extract is obtained using water, ethanol, or mixture solvent thereof. The composition is manufactured in the form of beverage. A composition for improving liver function contains bamboo sprout or bamboo leaf extract as an active ingredient.
PURPOSE: A complex natural antiseptic containing Rhus javanica L., Anemarrhenae rhizoma, and Ailanthus altissima swingle extract is provided to be applied to cosmetic products, mouth wash, and pharmaceutical products. CONSTITUTION: A complex antiseptic contains Rhus javanica L., Anemarrhenae rhizoma, and Ailanthus altissima swingle extract. The complex antiseptic also contains methyl gallate, anemarsaponin, stigma sterol, and cinnamic aldehyde. A cosmetic product contains 0.001-40 wt% of the complex antiseptic. A feed additive contains Rhus javanica L., Anemarrhenae rhizoma, and Ailanthus altissima swingle extract, methyl gallatae, anemarsaponin, stigma sterol, and cinnamic aldehyde. A feed contains 0.001-40 wt% of the feed additive.
A process for the preparation of 3-methyl-1,2,4-triazolyl-5-thioacetate (S)-2,6-diaminohexanoic acid comprises two stages. At first stage L-lysine aqueous solution is prepared by dissolution of L-lysine hydrochloride in water. Aqueous solution is passed through chromatographic column with ion-exchange resin (e.g. anionite in OHform) followed by passage of purified water up to absence of L-lysine in eluate and evaporation of eluate in vacuum up to obtaining concentration of L-lysine in residue of 35-45%. At second stage ethanol is added to aqeous solution of L-lysine, thereafter 3-methyl-1,2,4-triazolyl-5-thioacetate is added. The reaction mixture is boiled while stirring for 35-40 min., cooled by 3-, activated carbon is added, and boiling is carried out for some more 20-30 min. The mixture is filtered, and 96°ethyl alcohol is added to hot filtrate, cooled while stirring up to 25-, then to 0-, residue is filtered, washed with ethanol and dried. The desired product is prepared which biological activity is better than racemate activity, with maximum yield. Enlargement of arsenal of domestic pharmaceuticals for the treatment of cardiovascular and nervous system diseases is provided.
PURPOSE:To provide the titled inducing agent containing a separated polysaccharide component of ginseng as an active component. CONSTITUTION:A ginseng (plant of Araliaceae family, e.g. Panax ginseng, Panax notoginseng, Panax quinquefolium, etc.) is preferably crushed, extracted by immersing in water or a water-soluble organic solvent, and precipitated by adding an organic solvent to the extract. The precipitate is subjected to the chromatography with an ion exchange resin or a gel-filtration agent to obtain the objective polysaccharide component (e.g. composed of arabinose, galactose, glucose, etc. and having a molecular weight of preferably >=100,000). It can be used also or the remedy of cancer, etc. It is administered orally or parenterally in the form of powder, granule, tablet, capsule, syrup, injection, etc. at a dose of preferably 0.1-1,000mg/day in the case of oral administration in 1 - several divided doses.
BACKGROUND: Spontaneous hemopneumothorax is a rare condition that can be life-threatening if not promptly diagnosed and treated. We report a case of early treatment with transcatheter arterial embolization and video-assisted thoracoscopic surgery.
CASE PRESENTATION: A 19-year-old Japanese male was diagnosed with left pneumothorax and underwent chest tube drainage. A total of 10 hours after admission, the patient developed dyspnea, chest pain, and sudden massive bloody effusion. Contrast-enhanced computed tomography revealed contrast extravasation near the left lung apex, and spontaneous hemopneumothorax was diagnosed. Angiography revealed bleeding from a branch of the subscapular artery and transcatheter arterial embolization was performed. The patient underwent video-assisted thoracoscopic surgery and recovered uneventfully.
CONCLUSIONS: Anesthesiologists involved in urgent surgeries must be aware that a patient with spontaneous pneumothorax can develop a hemopneumothorax, even when full lung expansion has been obtained following chest tube drainage, owing to latent aberrant artery disruption. Interprofessional team engagement is essential for spontaneous hemopneumothorax management.
COVID-19 is a leading cause of death worldwide. The long-term effects of the virus are unknown. There is lack of reliable information about the natural history of post acute sequelae. Although there are limited evidence-based treatment guidelines, many patients receive unproven therapies. Given the mortality and morbidity associated with the illness and the growing number of patients who have survived COVID-19 the long-term effects are a growing area of inquiry. This study is designed to better understand the effects of SARS-CoV-2 that develop over time. This study will characterize the recovery process, epidemiology, and natural history of post-acute sequelae. This includes the clinical spectrum of recover and subsets of patients who have symptoms outside the standard course. Factors studied will include the individual, clinical context, severity of disease, duration of symptoms and the impact of treatment for acute SARS-CoV-2. This study will include a breadth of severity from those treated as outpatients, those requiring hospitalization, and those requiring critical care.

Key personnel will extract data recorded in the electronic health record (EHR) as part of routine clinical care in the evaluation in treatment of COVID-19 and its sequelae. Data such as incidence, prevalence, demographics, comorbidities, duration of illness, severity, level of medical care, measures of organ function, drug treatments, laboratory values, pulmonary function tests, computed tomography images, and other data from clinical care will be retrospectively entered into electronic data capture (REDCap).
292,984. Chemische Fabrik vorm. Sandoz. June 28, 1927, [Convention date]. Addition to 235,883, Medicines for internal use.-A remedy is obtained from the fresh roots or juices of radish (Raphanus Sativus) by the process described in the parent Specification for the treatment of garlic and the like. The dry odourless preparation of radish and adsorption charcoal so obtained may be administered as a powder or may be compressed into tablets.
All participants will receive a single, bolus iv injection of up to 100 µg \[68Ga\]Ga-DOTA-Cys-ATH001 (target dose of 200 MBq). At Visit 4, cohort 1b (healthy participants, n=3) and cohort 2b (presumed MASH participants, n=3) will come for a second PET/MR imaging visit within 6 weeks from the first imaging visit where an additional bolus iv injection of up to 100 µg \[68Ga\]Ga-DOTA-Cys-ATH001 will be administered.
Deep sternal wound infection (DSWI) is one of the potential and catastrophic complications after cardiac surgery. Despite the use of smaller incisions, routine application of prophylactic antibiotic and optimized blood glucose management, the incidence rate of DSWI still fluctuates between 1% and 5%. The early symptoms and signs of DSWI are not often obvious, making it too late for the clinicians to intervene in the process. Once left untreated, DSWI carries a very high mortality rate. Therefore, early prevention, diagnosis, and appropriate management of DSWI are crucial in preventing its progression to life-threatening outcomes. Considering the clinical severity and treatment complexity of DSWI, this article focuses on preventive experiences in each stage of DSWI, and reconstructive strategies after DSWI happens, raising attention among the medical community regarding DSWI.
Objectives. The present study aimed to assess whether occupational exposure to low concentrations of benzene, toluene, ethylbenzene and xylene (BTEX) is associated with color vision impairment. Methods. We queried PubMed, Scopus, Embase, Web of Science and ProQuest as the main databases, as well as gray literature such as Google Scholar. A random-effects model was used to assess relative risk. A funnel plot was created to assess publication bias. Meta-regression analysis was applied to identify variables that explain the between-study variation in the reported risk estimate. Results. An overall standardized mean difference of 0.529 (95% confidence interval [0.269, 0.788]; p < 0.0001) was obtained in the random-effects model, which corresponded to a medium-size effect. Duration and the levels of exposure to benzene, toluene and xylene were the significant predictors of the magnitude of the combined risk estimate. Chronic exposure to low levels of BTEX was associated with dyschromatopsia determined by the color confusion index. Conclusions. The impairments can occur even at exposures lower than the occupational exposure limits of BTEX. However, there are several flaws in the determination of workers' exposure, which did not allow to establish how low a level of these chemicals can cause color vision impairment.
PURPOSE: To treat a material contg. a phosphocaseinate of divalent cation such as calcium and/or magnesium phosphocaseinate. CONSTITUTION: When a casein-base material contg. a phosphocaseinate of divalent cation is treated, it is hydrolyzed with at least one kind of protease and the resultant hydrolyzate is recovered and subjected to at least one ultrafiltration process using a membrane capable of holding phosphopeptide to pass peptide. The residue is recovered, phosphopeptide contained in the residue is disaggregated and the residue is subjected to at least one ultrafiltration process using a membrane not holding phosphopeptide. Phosphopeptide is separated from the protease and recovered.
In his case report, a 74-year-old physically fit man was evaluated repeatedly for several years in the cardiology department due to dyspnoea on exertion (DOE). Several standard cardiac and pulmonary tests were performed but did not provide sufficient cause for the DOE. Lastly, the patient was evaluated with a cardiopulmonary exercise test (CPET) with simultaneous in- and expiratory gas sampling. The test revealed a low aerobic capacity due to chronotropic incompetence (CI), thus explaining the DOE. Subsequently, the patient was treated with a rate-responsive pacemaker. CPET-is an ideal test for diagnosing CI.
PURPOSE: To obtain a composition comprising ACE inhibitor alone or a mixture of the inhibitor with calcium channel blocker and capable of promoting diet by suppressing appetite and/or preventing or reducing anxiety accompanied by diet. CONSTITUTION: This composition comprises (A) angiotensin converting enzyme(ACE) inhibitor alone, e.g. phosphonate-substituted amino acid or imino acid, a proline derivative or a carboxyalkyldipeptide derivative or a mixture of the component A with (B) calcium channel blocker, e.g. diltiazem, 4-phenyl-1,4- dihydropyridine or verpamil. The preferable doses of the active ingredient compounds per Kg weight are shown as follows. A=0.1-25 mg and B=0.1-25 mg in the case of oral administration and A=0.01-1mg and B=0.01-2 mg in parenteral administration.
The invention belongs to the field of biomedical materials containing active protein and the field of regenerative medicine, and particularly provides a bone repair material containing rH-BMP2 and phosphate, which comprises modified chitosan, phosphate and rH-BMP 2. The material can be used for repairing bone injury. The bone repair material containing the rH-BMP2 and the phosphate comprises the following components in percentage by mass: rH-BMP 2: 1% -10%; and (3) chitosan: 10% -50%; tetracalcium phosphate: 10% -50%; calcium hydrogen phosphate: 5% -20%; disodium hydrogen phosphate: 0.2% -5; 0.2 to 5 percent of sodium dihydrogen phosphate. The invention takes the allyl trimethyl ammonium chloride or acrylamide modified chitosan and gelatin as the slow release carrier to realize great progress in degradation/drug release time and obviously reduce the anaphylaxis. The effect which is obviously superior to that of chitosan and the prior similar material is obtained in both in-vitro release experiments and animal experiments. The cytotoxicity test also preliminarily proves the safety of the compound.
In various countries worldwide, the incidence of colon cancer-related deaths has been on the rise in recent years. Early detection of symptoms and identification of intestinal polyps are crucial for improving the cure rate of colon cancer patients. Automated computer-aided diagnosis (CAD) has emerged as a solution to the low efficiency of traditional methods relying on manual diagnosis by physicians. Deep learning is the latest direction of CAD development and has shown promise for colonoscopic polyp segmentation. In this paper, we present a multi-level encoder-decoder architecture for polyp segmentation based on the Transformer architecture, termed NA-SegFormer. To improve the performance of existing Transformer-based segmentation algorithms for edge segmentation on colon polyps, we propose a patch merging module with a neighbor attention mechanism based on overlap patch merging. Since colon tract polyps vary greatly in size and different datasets have different sample sizes, we used a unified focal loss to solve the problem of category imbalance in colon tract polyp data. To assess the effectiveness of our proposed method, we utilized video capsule endoscopy and typical colonoscopy polyp datasets, as well as a dataset containing surgical equipment. On the datasets Kvasir-SEG, Kvasir-Instrument and KvasirCapsule-SEG, the Dice score of our proposed model reached 94.30%, 94.59% and 82.73%, with an accuracy of 98.26%, 99.02% and 81.84% respectively. The proposed method achieved inference speed with an Frame-per-second (FPS) of 125.01. The results demonstrated that our suggested model effectively segmented polyps better than several well-known and latest models. In addition, the proposed method has advantages in trade-off between inference speed and accuracy, and it will be of great significance to real-time colonoscopic polyp segmentation. The code is available at https://github.com/promisedong/NAFormer .
Standard dose IMVAMUNE® vaccine or placebo on Day 0 and Dryvax® vaccine or placebo on Day 7. This arm was discontinued from original protocol. Subjects already enrolled in this group will continue follow-up per protocol.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to solutions used for surgery irrigation and methods of their use, in part, to anti- inflammatory, analgetic and anticonvulsant solutions. Solution for continuous wound irrigation in the process of medicinal procedure has at least two inhibitory agent against pain/inflammation or spasm and solution is prepared on the base of physiological fluid. Physiological fluid acts as a carrier. Concentration of each agent in solution is 100.000 nanomoles, not above. Indicated inhibitory agents act by means of different molecular mechanisms in target-cells. Irrigating solution of the invention is a diluted solution that provides effect of suppression of pain, inflammation or spasm in low doses of inhibitory agent used. EFFECT: enhanced effectiveness of solution, valuable medicinal properties. 30 cl, 5 dwg, 22 tbl, 8 ex
BACKGROUND: Encephalocele refers to protrusion of the meninges and brain tissue through a skull bone defect. It results from congenital, traumatic, neoplastic, or spontaneous reasons. Traumatic encephalocele occurs because of the posttraumatic fracture of the skull bone or iatrogenic causes. The manifestations vary a lot, such as rhinorrhea, seizures, headaches, and focal neurological deficits.
CASE PRESENTATION: A 20-year-old Syrian male presented to our department with the complaint of clear cerebrospinal fluid drainage from his right nostril, which started 6 years ago after a head trauma, moderate headache, and episodes of tonic-clonic seizures without any response to medical treatment. Then, 2 months ago, the patient had meningoencephalitis, so he was admitted to the intensive care unit and treated for a month until he was cured. The patient underwent radiological investigations, which showed that he had a base fracture with an encephalocele in the nasal cavity. The brain tissues with the meninges herniated through the skull base fracture with a significant expansion of the subarachnoid spaces in the right hemisphere. He was advised to undergo surgical repair at that time, but he refused the surgery. During this visit, surgery was indicated. The surgery was done by a specialist who returned the herniated brain tissues to their normal location, repaired the meninges, and reconstructed the skull base with bone cement and bio-glue. The patient's recovery after the surgery was uneventful.
CONCLUSION: Traumatic encephalocele is a rare and unexpected complication of trauma, but we should keep it in mind when the patient comes with head trauma because of its life-threatening consequences. This complication can happen after years of trauma if the patient refuses treatment, therefore, we must educate patients about the dangerous results of neglecting cerebrospinal fluid leakage and skull fractures.
NEW MATERIAL:20-0-Phenoxycarbonylcamptothecin shown by formula I and 20-0-(4-piperidinopiperidino)carbonylcamptothecin shown by formula II. USE:An drug or an intermediate thereof. A compound shown by formula I is an intermediate for chemical modification of hydroxyl group at the 20-position thereof. A compound shown by formula II is a derivative having improved solubility in water. PREPARATION:Camptothecin is reacted with a phenylchlorocarbonic ester in the presence of a base such as pyridine to give 20-0- phenoxycarbonylcamptothecin shown by formula I. Then this compound is reacted with piperidinopiperidine to give 2-0-(4-piperidinopiperidino) carbonylcamptothecin shown by formula II.
Twenty-seven patients (46 hands) were admitted in this study. Patients were randomly divided three groups. The first group was ultrasound group, the second group was PH group and the third group was placebo US group. Continuous ultrasound with a frequency of 1 MHz, an intensity of 1.0 W/cm2 was used in the US and the PH groups. PH group received 0,1% dexamethasone. Placebo group received a frequency of 0 MHz, an intensity of 0 W/cm² ultrasound. Treatments were administered for 5 days a week, a total of 10 sessions. All patients also wore night splints during treatment. Visual Analogue Scale (VAS), Boston Symptom Severity Scale, Functional Capacity Scale, grip strength and electroneurophysiological evaluations were compared before the treatment, after the treatment and three months later.
A helminth protein immunogen is described. Included as the immunogen is an isolated protein comprising an immunogenic, extracellular fragment of a schistosome tegument protein selected from the group consisting of a TSP-1 protein; a TSP-2 protein; and a 7TM protein. An antibody which binds the isolated protein is also described. Additionally, an immunotherapeutic composition comprising the immunogenic protein and an immunologically acceptable carrier, diluent or excipient is described. Furthermore, a vaccine comprising the immunogenic protein is described. Also described are an isolated nucleic acid that encodes the immunogenic protein and a genetic construct comprising that isolated nucleic acid. Further, a host cell comprising the genetic construct is described. A method of immunizing against schistosomiasis including the step of administering the immunotherapeutic composition to an animal is also described. Other methods described include prophylactic or therapeutic treatment of schistosomiasis and of determining whether an animal has been exposed to, or harbours, a schistosome.