anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To accurately and quickly acquire all necessary information by providing the recording areas for the index information for individual identification of owners and the image information and enabling each owner to carry these recording areas individually. CONSTITUTION:A recording medium is provided with a user area for users to record and reproduce the information. Thus the individual medical treatment information A, B, C... are recorded together with the directory information a, b, c... corresponding to those medical treatment information respectively. In addition, the information (individual index information) on the face photo of the owner of a relevant optical disk, etc., is also recorded in a specific area of the user area. Thus the information on each individual is recorded to the recording medium and therefore a large quantity of information can be scattered for reduction of the quantity of information to be retrieved. Furthermore the index information is displayed in an image so that the accurate correspondence is secured between the owner of the information recording medium and the information recorded into the medium. Then the information is quickly and accurately retrieved.
Heparin has been shown to modulate binding of palifermin to the KGF receptor. Therefore, as part of a post-marketing regulatory commitment with the Food and Drug Administration (FDA), the purpose of this study is to characterize the potential pharmacokinetic and pharmacodynamic drug-drug interaction between a continuous IV infusion of heparin and an IV bolus injection of palifermin. If an interaction is observed during co-administration, it is expected that the outcome would be modulation of clearance of palifermin or a change in heparin activity. Although not commonly conducted, the literature describes heparin drug-drug interaction studies conducted in healthy subjects using both subcutaneous (Grimaudo et al,1988; Kroon et al, 1992) and intravenous (Caplain at al, 1999; Noveck \& Hubbard, 2004; Spowart et al, 1988) formulations. Based on these experiences, it is appropriate to investigate heparin drug-drug interactions in healthy subjects.

In this study, subjects will receive a single 60 mcg/kg dose of palifermin either as monotherapy or in conjunction with a continuous heparin infusion. The 60 mcg/kg dose of palifermin explored in this study is identical to the current recommended daily dosage for patients with hematologic malignancies who were undergoing autologous PBPC transplantation after receiving total body irradiation and high-dose chemotherapy: 3 consecutive days administered in two cycles with a 5-day non-dosing interval.
Gliclazide will be initiated and maintained at 30mg once a day until the completion of the study. Meanwhile, all patients will also continue on regimen of metformin 500mg three times a day throughout the study. Visits at 4-week intervals will be performed to evaluate the safety of drugs.
The invention provides a formula of Chinese herbal medicine for lipsotrichia stopping and hair growth and a preparation method thereof, belonging to the technical field of the Chinese herbal medicines. The formula comprises a medicine for oral administration and a medicine for external application. The medicine for oral administration is a clear solution which is prepared by the following steps of: weighing 13 kinds of Chinese herbal medicines such as ginseng, Chinese caterpillar fungus, herba cistanche, tuber fleeceflower root and the like according to the weight ratio, mixing and crushing the Chinese herbal medicines, adding water according to a proportion of 1:5, decocting and standing still for 48 hours. The medicine for external application is a clear solution which is prepared by the following steps of: weighing 14 kinds of Chinese herbal medicines such as asarum, tall gastrodia tuber, simpleleaf shrub chastetree fruit, feverfew and the like according to the weight ratio, mixing and crushing the Chinese herbal medicines, adding water according to a proportion of 1:10, decocting and standing still for 48 hours. The medicine for external application takes an effect in stopping lipsotrichia within 3 to 5 days on various lipsotrichia symptoms including seborrheic alopecia when used alone. The combination use of the medicine for oral administration and the medicine for external application can achieve very good hair growth effect on the various lipsotrichia symptoms including the seborrheic alopecia; and the grown hair is healthy and robust and does not fall off. The formula is a natural Chinese herbal medicinal solution and has the advantages of no simulation and no toxic or side effects.
South Asian men have lower cardiorespiratory fitness (CRF) than white men which is associated with a reduced capacity to oxidise fat during exercise. This is a risk factor for weight gain/regain. Whilst comparisons with Europeans are valuable, Asians are not a homogenous group and substantial differences in obesity and body fat partitioning exist with ethnicity. This cross-sectional pilot investigation aims to compare CRF and fat oxidation at rest and during exercise in Chinese, Indian and Malay men (from Singapore) with elevated BMI (23 -30 kg/m2). Forty-five men (15 each ethnicity) with elevated body mass index (23 -30 kg/m2) will complete testing in a fasted state on two separate mornings separated by ≥72 hours: (i) for a measure of CRF; and (ii) for a measure of fat oxidation at rest and during incremental exercise. A submaximal exercise test will be used to estimate CRF (maximum oxygen uptake, VO2max) during walking using a standard protocol where subjects walk on a treadmill at 5 km/h with regular increments in gradient until individuals reach 80% of their estimated maximum heart rate \[220 - age (years)\]. Perceived exertion will be monitored assessed periodically during the test and expired gases continuously measured via a mouthpiece attached to an automated metabolic cart (Parvomedics MMS-2400; Parvomedics, Sandy, UT). Oxygen consumption will be extrapolated to estimate VO2max based on estimated maximum heart rate. Resting fat oxidation will be determined via a 30 minute measure of expired gases under a ventilated hood attached to an automated metabolic cart. Fat oxidation during exercise will be determined via walking on a treadmill with increments in speed and gradient until the respiratory exchange ratio is ≥ 0.95. Primary outcomes will be compared among groups and adjusted for any covariates (e.g., BMI, body fat percentage) as necessary.
Pulmonary alveoli are functional units in gas exchange in the lung, and their dysfunctions in lung diseases such as interstitial pneumonia are accompanied by fibrotic changes in structure, elevating the stiffness of extracellular matrix components. The present study aimed to test the hypothesis that such changes in alveoli stiffness induce functional alteration of epithelial cell functions, exacerbating lung diseases. For this, we have developed a novel method of culturing alveolar epithelial cells on polyacrylamide gel with different elastic modulus at an air-liquid interface. It was demonstrated that A549 cells on soft gels, mimicking the modulus of a healthy lung, upregulated mRNA expression and protein synthesis of surfactant protein C (SFTPC). By contrast, the cells on stiff gels, mimicking the modulus of the fibrotic lung, exhibited upregulation of SFTPC gene expression but not at the protein level. Cell morphology, as well as cell nucleus volume, were also different between the two types of gels.
Signs and symptoms of digoxin toxicity include anorexia, nausea, vomiting, visual changes and cardiac arrhythmias [first-degree, second-degree (Wenckebach), or third-degree heart block (including asystole); atrial tachycardia with block; AV dissociation; accelerated junctional (nodal) rhythm; unifocal or multiform ventricular premature contractions (especially bigeminy or trigeminy); ventricular tachycardia; and ventricular fibrillation]. Toxicity is usually associated with digoxin levels greater than 2 ng/ml although symptoms may also occur at lower levels. Low body weight, advanced age or impaired renal function, hypokalemia, hypercalcemia, or hypomagnesemia may predispose to digoxin toxicity. Obtain serum digoxin levels in patients with signs or symptoms of digoxin therapy and interrupt or adjust dose if necessary [see Adverse Reactions (6) and Overdosage (10)]. Assess serum electrolytes and renal function periodically.

  


The earliest and most frequent manifestation of digoxin toxicity in infants and children is the appearance of cardiac arrhythmias, including sinus bradycardia. In children, the use of digoxin may produce any arrhythmia. The most common are conduction disturbances or supraventricular tachyarrhythmias, such as atrial tachycardia (with or without block) and junctional (nodal) tachycardia. Ventricular arrhythmias are less common. Sinus bradycardia may be a sign of impending digoxin intoxication, especially in infants, even in the absence of first-degree heart block. Any arrhythmias or alteration in cardiac conduction that develops in a child taking digoxin should initially be assumed to be a consequence of digoxin intoxication.

  


Given that adult patients with heart failure have some symptoms in common with digoxin toxicity, it may be difficult to distinguish digoxin toxicity from heart failure. Misidentification of their etiology might lead the clinician to continue or increase Digoxin dosing, when dosing should actually be suspended. When the etiology of these signs and symptoms is not clear, measure serum digoxin levels.
Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery. The inhibitory immune checkpoint Programmed Cell Death Protein 1 (PD-1) is upregulated on macrophage precursors (monocytes) in the blood after acute cerebrovascular injury. To investigate the therapeutic potential of PD-1 activation, we immunophenotyped circulating monocytes from patients and found that PD-1 expression was upregulated in the acute period after stroke. Murine studies using a temporary middle cerebral artery (MCA) occlusion (MCAO) model showed that intraperitoneal administration of soluble Programmed Death Ligand-1 (sPD-L1) significantly decreased brain edema and improved overall survival. Mice receiving sPD-L1 also had higher performance scores short-term, and more closely resembled sham animals on assessments of long-term functional recovery. These clinical and radiographic benefits were abrogated in global and myeloid-specific PD-1 knockout animals, confirming PD-1+ monocytes as the therapeutic target of sPD-L1. Single-cell RNA sequencing revealed that treatment skewed monocyte maturation to a non-classical Ly6Clo, CD43hi, PD-L1+ phenotype. These data support peripheral activation of PD-1 on inflammatory monocytes as a therapeutic strategy to treat neuroinflammation after acute ischemic stroke.
The study involves 1 screening visit of approximately 1 hour and 4 study days of approximately 10 hours. The subject will be asked to arrive in the fasted state on all study days. Fasting prior to screening is not required. On the screening day, body weight and height will be measured and Dual-energy X-ray absorptiometry (DXA) will be performed to measure body composition. After 4 hours subjects received a continuous intravenous infusion with OP in a dosage of 1 g /h. Next to the stable tracers provided to determine OP metabolism, stable tracers of phenylalanine (PHE) and tyrosine (TYR) may be provided to determine the effect of OP on protein metabolism at plasma and muscle tissue level. This required 2 muscle biopsies and on 2 study days 1 set of stable tracer pulses.
Budesonide, like other corticosteroids, is secreted in human milk. Data with budesonide delivered via dry powder inhaler indicates that the total daily oral dose of budesonide available in breast milk to the infant is approximately 0.3% to 1% of the dose inhaled by the mother [seeClinical Pharmacology, Pharmacokinetics, Special Populations, Nursing Mothers (12.3)]. No studies have been conducted in breastfeeding women specifically with PULMICORT FLEXHALER; however, the dose of budesonide available to the infant in breast milk, as a percentage of the maternal dose, would be expected to be similar. PULMICORT FLEXHALER should be used in nursing women only if clinically appropriate. Prescribers should weigh the known benefits of breastfeeding for the mother and the infant against the potential risks of minimal budesonide exposure in the infant. Dosing considerations include prescription or titration to the lowest clinically effective dose and use of PULMICORT FLEXHALER immediately after breastfeeding to maximize the time interval between dosing and breastfeeding to minimize infant exposure. However, in general, PULMICORT FLEXHALER use should not delay or interfere with infant feeding.
The invention provides a traditional Chinese medicine preparation for externally treating cold-dampness arthralgia syndrome, relating to the field of Chinese medical treatment on traditional Chinese medicine arthralgia syndrome. The traditional Chinese medicine arthralgia syndrome belongs to current common diseases and frequently encountered diseases and is mainly characterized by pain, numbness, heaviness and unfavorable flexion and extension of muscles, bones and joints or even arthrocele and the like clinically. In the modern medicine, rheumatic arthritis, rheumatoid arthritis, gout, Raynaud's disease, ankylosing spondylitis, sciatica, osteoarthritis, hyperosteogeny and other degenerative changes belong to the field of arthralgia syndrome. The traditional Chinese medicine preparation for externally treating arthralgia syndrome has simple, convenient and easy paths, can avoid stimulation caused by alimentary tract administration, and can reduce toxic side effects of medicines. The traditional Chinese medicine prescription for externally treating cold-dampness arthralgia syndrome, which is provided by the invention, is prepared from american lopseed, clematis root, curcuma, argyi leaf, chuanxiong rhizome, safflower, mastic, myrrh, szechuan aconite and wild aconite, and has the functions of expelling wind and removing damness, activating blood circulation to dissipate blood stasis and eliminating cold to stop pain. The modern iontophoresis treatment technology is combined for treating arthralgia syndrome, thereby being favorable for the percutaneous absorption of the traditional Chinese medicine, increasing the effective utilization of the traditional Chinese medicine components, and acquiring a more satisfactory clinical treatment effect.
The invention relates to traditional Chinese medicine rhubarb pills for treating infertility, mainly solve the problems of poor curative effect and side effect in the existing medicines for treating infertility. The traditional Chinese medicine rhubarb pills are prepared by the following steps: taking 100g of rhubarb, 100g of Jiananchen, 100g of costus root, 100g of asarum, 100g of peach kernel, 100g of fructus aurantii, 100g of aster and 100g of licorice; and baking, grinding together, adding honey, making pills (each pill weighs 5g). Four pills are taken each time in the morning and at night. Eight pills are taken at the delayed menstrual cycle. The total effective rate for treating infertility is higher than 95%, and the cure rate is higher than 80%. The pills have no toxic or side effect.
A composition for controlling acquired immune function suppression according to the present invention includes, as an active ingredient, lactic acid bacteria products from lactic acid bacteria of the genus  Lactobacillus . This composition for controlling acquired immune function suppression controls the suppression of acquired immune function due to the use of an anti-influenza drug. The lactic acid bacteria of the genus  Lactobacillus  is preferably of the subspecies  bulgaricus . For example, the lactic acid bacteria of the genus  Lactobacillus  may be  Lactobacillus delbrueckii  subsp.  bulgaricus . In the production method according to the present invention, a milk-based starting material is supplied to lactic acid bacteria of the genus  Lactobacillus  in order to produce the composition for controlling acquired immune function suppression to control the suppression of acquired immune function due to the use of an anti-influenza drug.
NGS will be performed on voided urine collected as routine care approximately 30 days prior to surgery. Results will be presented to Infectious Disease pharmacist within 48-72 hours to help select the most appropriate antibiotics, and independently as part of routine care, surgeons will choose the antibiotic that they would use in each case, while the Infectious Disease pharmacists would select their optimum choice. Approximately 220 subjects will be randomly assigned in a 1:1 ratio to receive either NGS antibiotic recommendation or standard of care (SOC) prophylaxis prescribed treatment. Subjects assigned to standard of care will have urine cultures sent for analysis, and the physician will choose antibiotics based on results as per usual practice. Subjects assigned to the NGS group, in addition to routine urine culture results, will have NGS urine culture results sent to an investigational drrug (ID) pharmacist, and recommendations will be shared with the physician to determine the antibiotic selection. The physician will ultimately decide the appropriate antibiotics to prescribe. Approximately 7-14 days after surgery, the research staff will conduct a telephone call to ask about any post-operative infections, complications, and any additional antibiotics that were prescribed.
PURPOSE:To obtain a bathing agent providing a visible pleasant feeling as well as bathing effects, increasing pleasure of bathing, containing foams comprising gelatin, water, a polyhydric alcohol and a pressure gas. CONSTITUTION:100 pts.wt. aqueous solution of gelatin is blended with 2-6 pts.wt. pressure gas such as carbon dioxide gas or nitrogen gas to contain foams, further with a polyhydric alcohol, properly an inorganic acid, an organic acid, fats and oils, extracted essence of crude drug, perfume, a dyestuff, an alcohol, a surfactant, a germicidal antiseptic, etc., the mixed solution is sprayed to a container and allowed to stand until gelatin is gelatinized to give the objective substance. The substance is made into various forms such as flowers and animals. The amount of gelatin blended is 10-50wt.% based on total amounts of bathing agent composition and that of the polyhydric alcohol is 20-50wt.%.
Dabigatran: one capsule in the morning and 1 capsule in the evening. Twice daily (bis in die = bid).
Patients receive vincristine sulfate IV on days 1, 29, and 57; prednisone PO BID on days 1-5, 29-33, and 57-61; mercaptopurine PO QD on days 1-84; methotrexate PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78; and methotrexate IT on day 1. Treatment repeats every 84 days until the total duration of study treatment is 2 years from the start of interim maintenance therapy (approximately week 119) (for girls with T-ALL) and all patients with T-LLy, and 3 years from the start of interim maintenance therapy (approximately week 171) (for boys with T-ALL).
Participants will receive an 8-week intervention which will include weekly sessions that are delivered in an alternating group-individual format. Sessions will provide participants the opportunity to practice and apply self-monitoring techniques across a variety of shopping tasks and settings to promote generalization and transfer of learning (Phase B).
Endotracheal intubation is most commonly taught and performed with the patient supine. Recent literature suggests that elevating the patient's head to a more upright position may decrease peri-intubation complications. However, there is little data on success rates of upright intubation in the emergency department. The goal of this study was to measure the association of head positioning with intubation success rates among emergency medicine residents. Study design was a prospective observational study. Residents performing intubation recorded the angle of the head of the bed, and the number of attempts required for successful intubation was recorded by faculty and respiratory therapists. The primary outcome of first past success was calculated with respect to three groups: 0-10 degrees (supine), 11-44 degrees (inclined), and ≥45 degrees (upright); first past success was also analyzed in 5 degree angle increments.
Chronic wounds can be classified as diabetic foot ulcers, pressure ulcers, or venous leg ulcers. Chronic wound management has become a threat to clinicians and constitutes a major healthcare burden. The healing process of chronic wounds requires many factors to work in concert to achieve optimal healing. Various treatment options, ranging from hypoxia to infection, have evolved considerably to address the challenges associated with chronic wound healing. The conventional and accelerating treatments for chronic wounds still represent an unmet medical need due to the complex pathophysiology of the chronic wound microenvironment. In clinical settings, traditional chronic wound care practices rely on nonspecific topical treatment, which can reduce pain and alleviate disease progression with varying levels of success but fail to completely cure the wounds. Conventional wound dressings, such as hydrocolloids, gauze, foams, and films, have also shown limited success for the treatment of chronic wounds and only act as a physical barrier and absorb wound exudates. Emerging advances in treatment approaches, including novel therapies (stem cells, microRNAs, and nanocarrier-based delivery systems) and multifunctional biological dressings, have been reported for chronic wound repair. This review summarizes the challenges offered by chronic wounds and discusses recent advancements in chronic wound treatment.
BACKGROUND: This paper attempted to clarify the role and mechanism of vacuolar protein sorting-associated protein 72 homolog (VPS72) in the progression of prostate cancer (PCa).
METHODS: Clinical information and gene expression profiles of patients with prostate cancer were obtained from The Cancer Genome Atlas (TCGA). VPS72 expression in PCa and the potential mechanism by which VPS72 affects PCa progression was investigated. Next, we performed COX regression analysis to identify the independent prognostic factors of PCa, and constructed a nomogram. The sensitivity of chemotherapeutic medications was anticipated using "pRRophetic". Subsequently, in vitro assays to validate the effect of VPS72 on PCa cell proliferation, migration and susceptibility to anti-androgen therapy.
RESULTS: The expression of VPS72 was considerably higher in PCa tissues compared to normal tissues. Significant correlations were found between high VPS72 expression and a poor prognosis and adverse clinicopathological factors. The nomogram model constructed based on VPS72 expression has good predictive performance. According to GSEA, VPS72-related genes were enriched in the NF-kB pathways, cytokine-cytokine receptor interaction and chemokine signaling pathway in PCa. Although PCa with low VPS72 expression was more adaptable to chemotherapeutic medications, our in vitro experiment showed that VPS72 knockdown significantly decreased the PCa cell migration, proliferation, and resistance to anti-androgen therapy.
CONCLUSIONS: In summary our findings suggests that VPS72 could play a crucial role in the malignant progression of PCa, and its expression level can be employed as a possible biomarker of PCa prognosis.