anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
According to the present invention, provided is a sheet-type mask pack using hydrogen water, which is conveniently used and has moisturizing and nourishing effects on the skin of a users face or the like by applying a sheet-type mask pack material in a paste state to a sheet such as a nonwoven fabric or the like, wherein the sheet-type mask pack material uses a cosmetic material made of a mineral-containing natural material and hydrogen water. The sheet-type mask pack using hydrogen water can have an excellent far infrared radiation effect and a waste substance eliminating effect by using the mineral-containing natural material, and can have a wrinkle alleviating effect caused by skin lifting action. The sheet-type mask pack using hydrogen water has an anti-aging effect caused by the high antioxiative activity of hydrogen and has an enhanced skin penetrating function caused by the small molecular size of hydrogen. The sheet-type mask pack using hydrogen water comprises: a first release paper; a nonwoven fabric whose one surface is bonded to the first release paper, and the other surface is coated with a cosmetic material in a paste state; and a second release paper which is bonded to the other surface of the nonwoven fabric coated with the cosmetic material. The cosmetic material comprises: 35-45 parts by weight of a mineral-containing natural material, 3-6 parts by weight of a dispersing agent, 0.1-8 parts by wight of a thickening agent, and 45-55 parts by weight of hydrogen water. The mineral-containing natural material includes at least one among loess powder, mud powder, and volcanic ash powder. The hydrogen water has an oxidation-reduction potential value of -600 mV and a hydrogen concentration of 1000-1650 ppb.
A method and a system for matching medical condition information with medical resources are provided. Specifically, a plurality of medical resources such as, for example, practitioners, specialists, specialty hospitals, or any other medical or extended care providers may have information related thereto stored within a database on a computer network. The information may include information on specific medical conditions, such as, for example, diseases, disorders, or any other medical condition. Alternatively, the medical resource may include information on specific medical procedures in which the medical resource may have a specialty or may otherwise perform. An individual may access a website connected with the database and may enter information on medical conditions and/or medical procedures. A search of the database may then reveal specific medical resource categories and, thence, medical resources that may treat the medical condition or may perform the medical procedures chosen by the individual.
Provided are immunomodulatory proteins containing an engineered variant CD80 extracellular domain that exhibits improved PD-L1 binding. The immunomodulatory proteins include variant CD80 domains with amino acid substitutions in the IgV domain. Among the provided immunomodulatory proteins are variant CD80-Fc fusion proteins. Also provided are cell therapies, such as T cell therapies, engineered with secretable or transmembrane immunomodulatory proteins containing the variant CD80 disclosed herein. In some aspects, the provided immunomodulatory proteins are capable of antagonizing PD-1/PD-L1 in addition to providing CD28 costimulation in a PD-L1 -dependent fashion. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders, or conditions, such as cancer. Also provided are compositions and methods for making and using such immunomodulatory proteins as well as compositions and methods for making and using such cell therapies.
The online CDSMP is an internet-based program for people with 1 or more chronic conditions. It's built on self-efficacy theory, facilitated by lay leaders, and uses a curriculum emphasizing problem solving, decision making, and confidence building in weekly sessions over six weeks. It addresses generic topics and skills relevant to managing any chronic condition, including: action plans; problem solving; nutrition; exercise; fatigue; breathing; managing medications; managing stress and emotions; working with health care providers. The structure includes: 1) password-protected, interactive web-based instruction; 2) web-based bulletin board discussion groups to enable participatory learning and support; 3) and a reference book that contains the program content and supplemental information.
BACKGROUND: The National Institutes of Health Stroke Scale (NIHSS) does not equitably assess stroke severity in the two cerebral hemispheres. By attributing a maximum of two points for neglect and seven for language, it undervalues right hemisphere deficits. We aimed to investigate if NIHSS equally predicts right hemisphere lesion volumes in patients with and without neglect, and if a modification of the neglect scoring rules could increase its predictive capacity.
METHODS: We analyzed a prospective cohort of acute right middle cerebral artery ischemic stroke patients. First, we calculated the correlation between NIHSS scores and lesion volume and analyzed the partial correlation of neglect. Then, we applied different modifications in the neglect scoring rules and investigated how they interfered with lesion volume predictive capacity.
RESULTS: A total of 162 ischemic stroke patients were included, 108 with neglect and 54 without. The correlation between lesion volume and NIHSS was lower in patients with neglect (r = 0.540 vs. r = 0.219, p = 0.004) and neglect was a statistically significant covariate in the partial correlation analysis between NIHSS and lesion volume (p = 0.017). With the neglect score tripled and with the duplication or triplication of all neglect modalities, the correlation was significantly higher than with the standard NIHSS (p = 0.043, p = 0.005, p = 0.001, respectively). With these modifications, neglect was no longer a significant covariable in the partial correlation between lesion volume and NIHSS.
CONCLUSION: A modification of NIHSS neglect scoring might improve the scale's capacity to predict lesion volume.
Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase- related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds of the invention consist of linked indole derivatives having at ' least two bicyclic rings of formula FIG. 6C in which R1R7 are defined as in claim 1 and in which the fused five membered ring contains a nitrogen atom and the fused six membered ring optionally contains one or two nitrogen atoms. The two or more bicyclic rings of Figure 6c are joined by a multifunctional bridge moiety substituted by two or more linking groups L which are joined to the bicyclic ring.
BACKGROUND: Autologous haematopoietic stem cell transplant (HSCT) is considered an effective treatment for highly active multiple sclerosis (MS). To date, most research has focused primarily on disease outcome measures, despite the significant impact of neuropsychological symptoms on MS patients' quality of life. The current systematic review aimed to examine whether HSCT for MS impacts neuropsychological outcome measures such as cognition, fatigue, mood, and quality of life.
METHODS: The review was registered with the International Prospective Register of Systematic Reviews (PROSPERO, ID: CRD42023474214). Systematic searches were carried out in six databases (PsycINFO, PubMed, Embase, Scopus, CINAHL and Web of Science) based on the following inclusion criteria: (i) published in peer-reviewed journals in English; (ii) longitudinal studies of adults with MS (iii) at least one neuropsychological outcome was assessed pre- and post-HSCT using standardised measures. Risk of bias was assessed using the National Heart, Lung and Blood Institute (NHLBI) quality assessment tools. A narrative synthesis was used to present results.
RESULTS: Eleven studies were included in the review. Long-term improvements in quality of life post-HSCT were identified. In terms of cognition and fatigue, the evidence was mixed, with some post-HSCT improvements identified. Decline in cognitive performance in the short-term post-HSCT was observed. No changes in mood were identified post-HSCT. Arguments for interpreting these results with caution are presented based on risk of bias. Arguments for interpreting these results with caution are presented based on risk of bias. Limitations of the evidence are discussed, such confounding variables and lack of statistical power.
CONCLUSION: The evidence base for the impact of HSCT for MS on neuropsychological outcomes is limited. Further research is required to progress understanding to facilitate clinician and patient understanding of HSCT treatment for MS.
The invention provides a preparation method of three-ginseng body nourishing oral liquid, and belongs to a preparation method in the technical field of green medicine and food. The three-ginseng body nourishing oral liquid comprises red ginseng, radix scrophulariae, salviae miltiorrhizae, radix rehmanniae, wolfberry fruit, liquorice, rhizoma alismatis and ligusticum wallichii which are Chinese herbal medicines. The preparation method comprises the following steps: respectively washing the Chinese herbal medicines with clear water, simultaneously mixing the Chinese herbal medicines together at a specific ratio, adding water, the weight of which is five times of the weight of the medicines, soaking for two hours, grinding, then boiling the Chinese herbal medicines for half hour, decocting for half hour with small slow fire, squeezing out serous liquid from the Chinese herbal medicines with cloth, adding sugar to the serous liquid, boiling for 15 minutes, cooling, packaging in bottles and carrying out sealing preservation. The three-ginseng body nourishing oral liquid enters human bodies and is fully absorbed. The absorption rate of the three-ginseng body nourishing oral liquid in the human bodies can be increased by above 90%. Due to the adoption of the preparation method, the utilization rate of the medicines is greatly increased. The three-ginseng body nourishing oral liquid has the advantages of building bodies, promoting blood circulation to remove blood stasis, softening blood vessels, nourishing heart blood, moistening liver, enhancing immunity and resisting fatigue.
A PLA procedure uses high-energy radio waves to treat liver tumors. Using CT and ultrasound guidance the doctor inserts a thin, needle-like probe into the liver tumor A high-frequency current is then passed through the tip of the probe, which heats the tumor with the goal to destroy the cancer cells. This may be done as an outpatient procedure or a short (1-2 day) hospital stay. PLA is the standard treatment for patients with liver cancer who cannot undergo liver surgery.
PURPOSE:To provide an acid-setting dental restoration composition having shortened setting time, improved crushing strength and suppressed cracking tendency caused by drying and shrinking, by compounding two kinds of calcium phosphates having different Ca/P gram-atom ratios. CONSTITUTION:The titled composition contains (A) is calcium phosphate having a Ca/P gram-atom ratio of 1.30-1.55 (e.g. alpha- or beta-tricalcium phosphate or octacalcium phosphate) and (B) a calcium phosphate having a Ca/P gram-atom ratio of 1.56-2.1 (e.g. hydroxyapatite or tetracalcium phosphate) at a weight ratio (A:B) of 20:1-1:20. The composition is cured by kneading with an acidic aqueous solution of pH3.5-6.5. For example, 1M citric acid solution is adjusted to pH5 with ammonia water and used at a weight ratio (composition/kneading liquid) of 3.1-6. The above composition is preferably added with a fluoride such as calcium fluoride in an amount to attain a Ca/F gram-atom ratio of 4.2-60.
BACKGROUND: The characteristics and clinical outcomes associated with sustained ventricular tachycardia and fibrillation (VT/VF) in Japanese acute myocardial infarction (AMI) patients remain unknown.
METHODS AND RESULTS: Consecutive AMI patients (n=1,941) transferred to the Hirosaki University Hospital and treated with primary percutaneous coronary intervention (PCI) within 12 h of onset were retrospectively studied. The incidence of VT/VF during hospitalization was 8.3%, and 75% of cases occurred by the end of PCI. Independent predictors associated with VT/VF occurrence by the end of PCI and after PCI, respectively, were identified. Additionally, the differences between patients with VT and VF were examined, which revealed that the characteristics of patients and predictors for VT and VF were clearly different. Additionally, the QRS duration during VT was measured, which demonstrated the possible involvement of Purkinje fibers for VT in the acute phase of AMI. Of the patients with VT/VF, 12% required ECMO support due to refractory VT/VF despite intravenous antiarrhythmic agents such as β-blockers, amiodarone, and nifekalant. Among the patients discharged alive, 1,690 were followed up for a mean of 3.7 years. VT/VF occurrence during hospitalization did not affect the mid-term clinical outcomes even in patients with VT.
CONCLUSIONS: The results clearly indicated that VT/VF is still a serious complications of AMI. We need to identify patients at high risk of developing VT/VF for careful observation and appropriate intervention.
1. Technical Result Increase in yield, purity and activity of the final product.            2. Essence Raw peat is extracted. From the extract humus substances are eliminated by acidification with hydrochloric acid to (pH 1,5-3,0) and se¬paration. The extract is concentrated by evapo¬ration and/or nanofiltration under low pressure with simultaneous elimination of inorganic salts.            pH of the concentrated extract is brought to 6,0-7,1 and is concentrated to thick syrup. The syrup is then heated up to 70-90°C until comple¬tion of Amadori rearrangment reaction of the product resulting from the reaction of simple sugars, oligo - and polysaccharides with amino acids and/or peptides extracted from peat.           After reaching maximal rearrangment the mixture is cooled and the obtained hudrophobic substrate is eliminated by selective adsorption.            3. Field of Application Medicine, pharmaceutical industry.
PURPOSE:A dermal external drug, containing methylhydroquinone and capable of exhibiting more remarkably improved skin beautifying and whitening effect than hydroquinone. CONSTITUTION:A dermal external drug containing methylhydroquinone expressed by the formula. The compound expressed by the formula is a compound obtained by substituting one of the hydrogen atoms in the parent nucleus of the hydroquinone by methyl group, but exhibits more remarkably improved beautifying and whitening effect than the hydroquinone. The amount of the compound expressed by the formula to be incorporated is preferably 0.1-5wt%. An oil, humectant agent, surfactant, etc, may be optionally incorporated in addition to the essential component expressed by the formula. The addition of an ultraviolet light absorber or well-known beautifying and whitening agent is further effective for preventing and treating liver spot, ephelis, etc.
Concurrent endocrine therapy and radiotherapy. Concurrent endocrine therapy will be defined as, the commencement of endocrine therapy around 2 weeks before (a minimum of 1 week before to a maximum of 4 weeks) commencement of radiotherapy and continued throughout radiotherapy.
FIELD: medicine, veterinary science, cosmetics. SUBSTANCE: one should obtain phytochitodesis - chitodesis molecular complex - water-soluble form of chitosan of polyfractional composition at molecular weight from monomeric link - glucosamine up to about 150 kDa and deacetylation degree from about 68 up to ≤95% with dry extract of medicinal plant raw material. Moreover, chitodesis is obtained based upon chitosan isolated out of solution with alkali at pH = 6.8 - 7.5 and rendered amorphous, and either organic acid or organic acid anhydride. The stage to obtain chitodesis solution should be carried out in liquid extract of medicinal plants in demineralized water at chitodesis to dry extract of phytospecies ratio in target product being 1 : 0.6-0.9. Target product is obtained due to freeze drying technique. EFFECT: higher biological activity.
Obesity is a major global health epidemic that has adverse effects on both the people affected as well as the cost to society. Several anti-obesity drugs that target GLP-1 receptors have recently come to the market. Here, we describe the effects of tesofensine, a novel anti-obesity drug that acts as a triple monoamine neurotransmitter reuptake inhibitor. Using various techniques, we investigated its effects on weight loss and underlying neuronal mechanisms in mice and rats. These include behavioral tasks, DeepLabCut videotaped analysis, electrophysiological ensemble recordings, optogenetic activation, and chemogenetic silencing of GABAergic neurons in the Lateral Hypothalamus (LH). We found that tesofensine induces a greater weight loss in obese rats than lean rats, while differentially modulating the neuronal ensembles and population activity in LH. In Vgat-ChR2 and Vgat-IRES-cre transgenic mice, we found for the first time that tesofensine inhibited a subset of LH GABAergic neurons, reducing their ability to promote feeding behavior, and chemogenetically silencing them enhanced tesofensine's food-suppressing effects. Unlike phentermine, a dopaminergic appetite suppressant, tesofensine causes few, if any, head-weaving stereotypy at therapeutic doses. Most importantly, we found that tesofensine prolonged the weight loss induced by 5-HTP, a serotonin precursor, and blocked the body weight rebound that often occurs after weight loss. Behavioral studies on rats with the tastant sucrose indicated that tesofensine's appetite suppressant effects are independent of taste aversion and do not directly affect the perception of sweetness or palatability of sucrose. In summary, our data provide new insights into the effects of tesofensine on weight loss and the underlying neuronal mechanisms, suggesting that tesofensine may be an effective treatment for obesity and that it may be a valuable adjunct to other appetite suppressants to prevent body weight rebound.
A pre-test will be conducted to determine socio-demographic data and to assess breast cancer awareness (champion health belief model scale). Experimental and control groups will be formed. The 45 people in the experimental group will be divided into 5 groups of 8 people. Each group will receive 45 minutes of theoretical training and 60 minutes of BSE application and will be explained and applications will be provided on the model. Question - Answer - 20 minutes will be allocated for feedback. 5 groups will be allocated one day each.4 weeks after the training, the experimental group will be called again in 5 groups and the champion health belief model scale will be repeated, they will be asked to perform the BSE application on the model and evaluation will be made according to the BSE evaluation form prepared by the researcher. 6 months after the study, the whatsapp group will be questioned about whether individuals have BSE.
FIELD: medicine, in particular, surgery; may be used in operations accompanied with liver hypoxia. SUBSTANCE: liver perfusion with antihypoxic solution is performed through umbilical vein. Perfusion is carried out in two stages. The first stage is started 10-15 min before manipulation of liver. Use is made of 0.9-% solution of sodium chloride saturated with ozone in concentration of 150-200 mcg/l and cooled to 25 C. Solution is introduced at the rate of 60 drops per minute. The second stage is started just after constriction of hepatoduodenal ligament. Use is made of 0.9-% solution of sodium chloride cooled to 15 C. Ozone concentration in solution is increased up to 500 mcg/l. Solution is introduced at the rate of 120 drops per minute. Liver perfusion is carried out during the entire period of constriction of hepatoduodenal ligament. Blood flow is restored. Liver is perfused for 15-20 min more. EFFECT: prolonged term of constriction of hepatoduodenum ligament operation and reduced probability of occurrence of postoperative complications.
Neurodevelopmental disorders, such as attention-deficit-hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), have been associated with a high prevalence of sensory processing anomalies. With the update of the diagnostic manuals International Classification of Diseases eleventh revision (ICD-11) and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), more emphasis has been given to the sensory symptoms of both these disorders. The demand of reliable and valid quantitative measurements of sensory processing anomalies are therefore increasing as such metrics has the potential to assist clinical decision-making e.g., in (differential) diagnostics and treatment response evaluation and prediction. The present observational study focuses on auditory and tactile processing. Hearing and touch are two of the most frequency reported modalities in which individuals with ASD experience sensory anomalies. In addition, adequate auditory and tactile processing are presumed fundamental in the emergence of various social and cognitive functions such as the development of language. Elucidating the sensory symptoms by means of psychophysics, neuroimaging, and quantitative measures of peripheral sensory organs could elucidate the underlying (neuro)physiology of sensory anomalies in ASD and ADHD.

The present project aims to elucidate the physiological substrates of abnormal sensory processing by conducting a battery of tests in children with ASD, ADHD, and neurotypical children. First, a series of questionnaires will be administered to acquire a (clinical) description of the participants (Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V); Autism Quotient (AQ, child version); Childhood Behavioral Checklist (CBCL 6-16); ADHD-Ration Scale (ADHD-RS); Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2); Use of pharmacotherapy). A standardized caregiver-reported sensory profile questionnaire will serve as the primary outcome (Sensory Profile 2, Child version). Second, transiently evoked otoacoustic emissions will be measured in order to account for peripheral mechanisms of hearing as well as their contralateral suppression to measure efferent auditory system functioning. Third, a psychophysic task will be conducted for the purpose of estimating the just-noticeable difference to auditory loudness and vibrotactile displacement intensities followed by a subjective categorical loudness scale experiment. Finally, two electroencephalographic experiments will be performed: a frequency tagging paradigm with interspersed pitch oddballs and a classical sensory gating paradigm using vibrotactile stimuli and auditory clicks.
A variety of nanoparticles or microparticles may be used to treat diseases such as restenosis or blood clots. For example, a nanoparticle or microparticle may include a core having a biodegradable polymer, an exterior having hydrophilic moieties. and a therapeutic agent. The nanoparticles may include targeting moieties that target the nanoparticle or microparticle to an arterial lesion. The nanoparticle or microparticle may include an exterior shell around the core to increase stability of the nanoparticle or microparticle. The nanoparticle or microparticle may include a magnetic particle to allow targeted delivery of the nanoparticle or microparticle via a magnetic field. The nanoparticles or microparticles may be coated on a medical device, such as a catheter balloon or a stent, or may be delivered systemically or locally to patients in need thereof.