anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a composition for the oral cavity, by blending an extract of Eugenia caryophyllata Thunb. and adjusting the pH within a specific range, capable of sustaining the stability of the extract of the Eugenia caryophyllata Thunb. without causing discoloration and deactivation of inhibitory action on halitosis. CONSTITUTION:A composition for the oral cavity obtained by blending an extract of Eugenia caryophyllata Thunb. known to give deodorizing effect, e.g. inhibition of halitosis, etc., by blending in a dentifrice composition in an amount of 0.0001-2wt%, preferably 0.001-1wt% based on the total composition and adjusting the pH of the composition to 4-7.5, particularly 5.5-7.5. Although the pH is preferably adjusted by using a phosphate based or citric acid based buffer agent, the adjustment can be carried out by blending a polishing agent, e.g. aluminum hydroxide treated with phosphoric acid, having <=8pH of a 10% aqueous suspension thereof.
The invention relates to a targeted superparamagnetic monodisperse nano-flower probe, the preparation and the application thereof. A nano-flower probe is composed of three parts, namely a magnetic gold-bearing particle nano-flower, a hyperbranched macromolecular HPG and a target molecule, wherein one end of the hyperbranched macromolecular HPG is provided with a mercapto group and a branched terminal. The nano-flower probe is prepared through the hot solvent method. That is, firstly, a Fe3O4 carrier is prepared. Secondly, a golden seed is loaded on the carrier, and then the magnetic gold-bearing particle nano-flower is obtained. Finally, the magnetic gold-bearing particle nano-flower is connected sequentially with the HPG and the target molecule. The above nano-probe is applied to the oncotherapy for animal in-vivo double-targeted imaging under the alternating magnetic field. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe is simple to prepare, low in cost, high in targeting efficiency, and small in oncotherapy side effect. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe has the advantages of simple preparation, low cost, high targeting efficiency, small oncotherapy side effect and the like.
The study population was participants with relapsing remitting multiple sclerosis. The traditional rehabilitation program consists of a joint treatment in which lower extremity strengthening and balance exercises are carried out synchronously for the experimental and control groups. Motor imagery and action observation therapy based on telerehabilitation of certain movements will be applied to the experimental group. All treatments will be carried out online via the zoom program. The treatment program will be applied 3 times a week for 6 weeks. Evaluations will be made before and after the treatment program. Assessments include balance, lower extremity muscle strength and functional mobility, fatigue, and quality of life.
Normally, some patients with prostate cancer undergo imaging tests to determine the extent (spread) of their disease. These imaging tests often give good information, but not in all patients and not every time. This study deals with a new imaging test known as F-DCFPyL-Prostate-specific Membrane Antigen (PSMA) Positron Emission Tomography (PET), or F-DCFPyL-PSMA PET. The objective of this study is to evaluate safety and usefulness of using F-DCFPyL in detecting recurrent/metastatic prostate cancer. The F-DCFPyL PET imaging technique is used in some parts of the world but is not currently standard imaging care. Better understanding how this new imaging test performs in identifying recurrent/metastatic prostate cancer may lead to better management of prostate cancer patients in the future.
Bag3 is a multifunctional protein expressed predominantly in the heart, the skeletal muscle, the central nervous system and in many cancers. Although BAG3 was cloned only a decade ago, studies have shown that genetic variants, particularly those that result in haplo-insufficiency, can lead to severe left ventricular dysfunction; however, the full mechanisms responsible have remained obscure. To obviate the influence of heart failure itself on the biology of Bag3, ransgenic mice harboring a single allele knock-out were studied between 8 and 10 weeks of age before any obvious signs of heart failure were evident. The results were surprising and informative. First, it was found that despite a normal phenotype, young Bag3+/− had marked changes in the proteome that were characterized by changes in proteins associated with metabolism and apoptosis. Consistent with this finding, a decrease in the levels of critical proteins charged with maintaining the mitochondrial membrane potential was observed. It was also found that young mice shifted from a balance between the extrinsic and intrinsic pathways of apoptosis. However, in the presence of stress and the absence of Bag3 there was a shift from a balanced to an extrinsic dominant system (cleaved caspase 8). The diverse array of critical pathways regulated by Bag3 suggests a more important role especially during stress and that this role might include serving as an intracellular glue that holds proteins where they can be most effective rather than having them meet accidentally.
This is a multicenter (study conducted at multiple sites), randomized (the study medication is assigned by chance), double-blind (neither the physician nor participant will know which of the treatments a participant is receiving, but can access the information in case of an emergency), and crossover (method used to switch participants from one treatment arm to another in a clinical study) study. Approximately 18 participants will participate in the study. The study will consist of screening phase (30 days before the administration of study drug), treatment phase, and follow-up phase (2 weeks after the end of the last treatment period). Participants will be randomly assigned to receive JNJ 40929837, placebo, and montelukast. Each participant will receive all the 3 treatments (7 days per treatment) and each treatment will be separated by 14 days of wash-out period (no treatment). Safety evaluations will include assessments of adverse events, clinical laboratory tests, electrocardiogram, vital signs, and physical examination, which will be evaluated throughout the study. The maximum study duration for a participant will be approximately 51 days.
Hair coloration compositions for application to hair are provided. In an embodiment, a hair coloration composition includes a plurality of particles. Each particle comprises a first layer of first material and a first layer of second material with an interface therebetween. The first material has a first refractive index and the second material has a second refractive index. The difference between the first refractive index and the second refractive index is greater than zero. Each particle is configured to exhibit a photonic band gap effect at the interface when exposed to incident white light.
New mouth and dental care prepns. contain readily soluble salts of formula X+(ZnCit)- (I) (where Cit is the citric acid residue; and X is cation which imparts good water solubility to the zinc/citric acid complex). The complexes (I) have anti-plaque activity. This is attributed to (a) ready absorption by the oral mucous membranes, (b) stimulation of saliva secretion, (c) gradual release of zinc ions, and (d) direct effects on oral bacteria. (I) are practically non-toxic. Their water-solubility is high, so that they can be administered orally in practically any amt. without the risk of crystal deposition.
One or more polysiloxanes, e.g. polymethyl siloxane, polyethylsiloxane and polyphenylsiloxane, preferably having a viscosity of between 20 and 100,000 centistokes at 25 DEG  C., are included in skin-protective compositions that are oil-in-water emulsions and which also contain one or more mineral or vegetable and one or more emulsifying agents, but not nitrocellulose.  The polysiloxanes may be present in the proportion of 4 to 35 per cent by weight of the compositions.  Specification 714,795, [Group VI], is referred to.ALSO:A skin protective composition which is oil-in-water emulsions comprise one or more polysiloxanes, one or more animal or vegetable fats are or were emulsifying agents and is devoid of nitrocellulose.  The preferred polysiloxanes used are polymethyl siloxane, polyethylsiloxane or polyphenylsiloxane and the viscosity is between 20 and 100,000 centistokes at 25 DEG  C.  By animal or vegetable fat is meant the triglycerides or triesters of glycerol and long chain aliphatic acids, both saturated and unsaturated, e.g. vegetable fats such as almond oil, arachis oil, cottonseed oil, olive oil, palm oil, sesame oil, castor oil and soya bean oil; animal fats such as prepared internal body fats, e.g. lard.  Suitable emulsifying agents are the salts of fatty acids, e.g. salts of stearic acid with alkali metal bases, e.g. sodium hydroxide, or with organic bases, e.g. triethanolamine, or combinations of fatty alcohols for example cetyl alcohol, stearyl alcohol and cetostearyl alcohol with long chain quaternary ammonium salts or mixtures thereof, e.g. cetrimide, or with sulphated fatty alcohols, for example dodecyl sulphate or their salts, e.g. sodium or triethanolamine dodecyl sulphate.  The compositions may contain from 4 to 35 per cent by weight of polysiloxane, from 2 to 50 per cent by weight of fat and from 3 to 15 per cent by weight of emulsifier, but the total polysiloxane content and fat content should not exceed 50 per cent by weight of the composition.  In an example a typical composition is prepared by mixing 4 parts of a polysiloxane (700 centistokes at 25 DEG  C.), 2 parts of olive oil and 10 parts of stearic acid at 60-65 DEG  C., and adding the mixture to a solution of 0.6 parts of sodium hydroxide in 65.4 parts of water at 60-65 DEG  C.  The mixture is then emulsified, coated and homogenized.  Specification 714,795 is referred to.
AIMS: This study aimed to develop and apply natural language processing (NLP) algorithms to identify recurrent atrial fibrillation (AF) episodes following rhythm control therapy initiation using electronic health records (EHRs).
METHODS AND RESULTS: We included adults with new-onset AF who initiated rhythm control therapies (ablation, cardioversion, or antiarrhythmic medication) within two US integrated healthcare delivery systems. A code-based algorithm identified potential AF recurrence using diagnosis and procedure codes. An automated NLP algorithm was developed and validated to capture AF recurrence from electrocardiograms, cardiac monitor reports, and clinical notes. Compared with the reference standard cases confirmed by physicians' adjudication, the F-scores, sensitivity, and specificity were all above 0.90 for the NLP algorithms at both sites. We applied the NLP and code-based algorithms to patients with incident AF (n = 22 970) during the 12 months after initiating rhythm control therapy. Applying the NLP algorithms, the percentages of patients with AF recurrence for sites 1 and 2 were 60.7% and 69.9% (ablation), 64.5% and 73.7% (cardioversion), and 49.6% and 55.5% (antiarrhythmic medication), respectively. In comparison, the percentages of patients with code-identified AF recurrence for sites 1 and 2 were 20.2% and 23.7% for ablation, 25.6% and 28.4% for cardioversion, and 20.0% and 27.5% for antiarrhythmic medication, respectively.
CONCLUSION: When compared with a code-based approach alone, this study's high-performing automated NLP method identified significantly more patients with recurrent AF. The NLP algorithms could enable efficient evaluation of treatment effectiveness of AF therapies in large populations and help develop tailored interventions.
A dispenser with an openable top (5) through which may be pulled the end of a continuous tissue (3) impregnated, e.g.  with eau-de-cologne, to provide a cooling and refreshing effect when rubbed on human skin, has in its base an extra charge (4) of liq. contg. deodorant. The liq., which may also contain a cleaning medium, soaks the emergent tissue to a wet rather than damp state so that when squeezed the liq. emerges and can be used directly for cleaning e.g. the arm-pit. A suitable mixt. has 80-95% of combined water/alcohol washing medium, with 0.2-5% of deodorants, perfume, fungicide etc.. ADVANTAGE - Dispenser combines useful range of extra functions.
The need of studies to develop programs of pharmaceutical attention for asthmatics was given because of the increase of incidence and prevalence of the disease in the population. This study had a descriptive, retrospective, transversal character with quantitative approach, which aimed to delineate the social-economics profile of the asthmatic patients that used the health service available at the Care Nucleon Medical Integrate (NAMI). The studied population was composed of 40 asthmatic patients who attended between April and May, during 2006. Data collection was performed through a semi-structured stereotypic questionnaire, with closed and opened questions. The age range of the interviewee between 0 to 5 years old represents the biggest percentage of patients, obtaining 60% of the answered questionnaires. According to social-economics conditions, 55% were illiterate or were learning to read, 75% were using some drug prescribed at NAMI, 72.5% deny completely the disease, 52.5% recognized the factors that triggered the asthmatic crisis and 55% said having often crisis. Seventy per cent (70%) of the interviewee showed some difficulty related to the use of the drugs; 47.5% have different problems related to the access to the medications. Through the analysis of the social-economics profile delineated of the asthmatics patients attended at NAMI, it could be revealed that the biggest part of the patients are people with little instruction, due to the social exclusion in which they are found; being the majority of them children of the female gender.
Clinical experience with mirtazapine in patients with concomitant systemic illness is limited. Accordingly, care is advisable in prescribing mirtazapine for patients with diseases or conditions that affect metabolism or hemodynamic responses.

Mirtazapine has not been systematically evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or other significant heart disease. Mirtazapine was associated with significant orthostatic hypotension in early clinical pharmacology trials with normal volunteers. Orthostatic hypotension was infrequently observed in clinical trials with depressed patients. Mirtazapine should be used with caution in patients with known cardiovascular or cerebrovascular disease that could be exacerbated by hypotension (history of myocardial infarction, angina, or ischemic stroke) and conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medication).

Mirtazapine clearance is decreased in patients with moderate [glomerular filtration rate (GFR) = 11 to 39 mL/min/1.73 m2] and severe [GFR < 10 mL/min/1.73 m2] renal impairment, and also in patients with hepatic impairment. Caution is indicated in administering mirtazapine to such patients (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
Neonates with congenital heart disease are at increased risk of adverse long term neurodevelopmental outcomes, including lower mean intelligent quotients (IQs). However, it is difficult to predict with neonates are most likely to be affected and a cost effective method is needed. AEEG has been used in neonates with hypoxic-ischemic encephalopathy and abnormal sleep wake cycles have been proposed to predict poorer long term outcomes. We thus hypothesize that abnormal sleep wake cycles in neonates with congenital heart disease will correlate with poorer outcomes. In our study, we will examine the relationship between performance on a neurodevelopmental screening tool, the Dubowitz neonatal neurological screening tool, and the sleep wake cycles on AEEG both before and after cardiac repair to try and predict which neonates are at increased risk of adverse long term outcomes. We will also compare the findings of the AEEG and performance on the neurodevelopmental tool to the data gathered from neonates without cardiac disease.
Methods: This will be a randomized trial structured as an equivalence trial. Subjects will be American Society of Anesthesiologists (ASA) I and II women aged ≥18 years, non-laboring, at term (\>37 weeks gestation) with singleton pregnancies in cephalic presentation, scheduled for elective cesarean delivery under spinal anesthesia. Patients will receive spinal anesthesia for cesarean section in the sitting position, after which they will lay either supine horizontal or the surgical table will be tilted to the left by 15°, depending on the group to which they were randomized (SUPINE or TILT). An IV phenylephrine infusion will be administered to maintain systolic BP at baseline until delivery. A noninvasive hemodynamic monitoring system (NICOM, Cheetah Medical Inc., Vancouver, WA, USA) will continuously monitor CO and stroke volume. Neonatal umbilical vein and arterial blood gas results will be recorded.The null hypothesis is that the position of the patient (supine horizontal or tilted) during cesarean section will make no difference to neonatal wellbeing.

Statistical Design: The estimated sample size is the minimum number of study subjects required for rejecting the alternative hypothesis (i.e., accepting the null hypothesis). A significant difference between groups in the primary outcome, umbilical artery BD (which is a measure of fetal well being at the time of delivery and an indirect indicator of the adequacy of uteroplacental perfusion) would be of the order of magnitude of 2 mmol/L. Standard deviation of BD tends to be of this magnitude also. It would therefore require 22 subjects per group for 90% power to detect this magnitude of difference with alpha 0.05. Because BD is often not normally distributed, it is appropriate to increase sample size by 10-20%, and because the investigators have important secondary outcomes (PE usage, UA and UV pH, UV BD) the investigators intend to recruit 50 subjects per group to allow sufficient power for analysis of these secondary outcomes with appropriate correction for multiple comparisons, and allowing for 10% dropout. PE usage in the investigators previous study tends to have a standard deviation of about 30% of the mean, also roughly the magnitude of a clinically significant difference.
PURPOSE:To provide a permanent hair-dressing agent having a specific initial viscosity, flowable at a relatively low temperature, free from dripping and flowing in application, and capable of impregnating in curled hair by heating to effect the sufficient moisturizing of the hair. CONSTITUTION:The objective permanent hair-dressing agent having initial viscosity of >=100m-poise and lowering the viscosity by <=60% to <=50m-poise when heated at 25-42 deg.C, can be prepared by adding a thickener to a hair-keratin reducing agent. The additive to increase the viscosity is selected from paraffin, vaseline, ceresin, fat alcohol, fatty acid, wax, polyglycol, their ether, ester, aminoxide, and lanolin derivative. The agent is applied to the hair wound around a curler, and heated at 25-42 deg.C (the body heat may be used) to decrese the viscosity. The hair is moisturized by the impregnated agent. After washing out the agent, the hair is treated with an oxidizing fixing agent to curl the hair in a uniform and permanent curl.
After enrolled in this study, the patient was first treated with radiotherapy, concurrent with oral S-1 80mg/m2/day, on radiotherapy days. 3 weeks after the end of radiotherapy, patients treated with neoadjuvant chemotherapy with oxaliplatin and S-1. Oxaliplatin is given on dose of 130mg/m2 iv on day 1; S-1 on 40-60mg po BID on day 1-14, oral. Imaging evaluation was performed 3 weeks after neoadjuvant treatment. The radical operation and surgical procedure were determined on MDT discussion. Non-operable patients continue with 3 cycles of chemotherapy, and the chemotherapy regimen can be changed. A 3 cycle of SOX adjuvant chemotherapy was performed after surgery.
A recombinant non-glycosylated mammalian growth factor (BTC-GF) stimulates proliferation of human smooth muscle cells.      Especially, the amino acid sequence of the protein deduced from the nucleotide sequence coding for human BTC-GF is as that comprising the amino acids No. 1 to No. 147 of Figure 10 or the amino acids No. 1 to 80 of Figure 10, and the amino acid sequence of the protein deduced from the nucleotide sequence coding far mouse BTC-GF is as that comprising the amino acids No. 1 to No. 146 of Figure 9.
Immune thrombocytopenia (ITP), an acquired autoimmune disease, is characterized by immune-mediated platelet destruction. A biomarker is a biological entity that contributes to disease pathogenesis and reflects disease activity. Metabolic alterations are reported to be associated with the occurrence of various diseases. As metabolic biomarkers for ITP have not been identified. This study aimed to identify metabolism-related differentially expressed genes as potential biomarkers for pathogenesis of ITP using bioinformatic analyses.The microarray expression data of the peripheral blood mononuclear cells were downloaded from the Gene Expression Omnibus database (GSE112278 download link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112278 ). Key module genes were intersected with metabolism-related genes to obtain the metabolism-related key candidate genes. The hub genes were screened based on the degree function in the coytoscape sofware. The key ITP-related genes were subjected to functional enrichment analysis. Immune infiltration analysis was performed using a single-sample gene set enrichment analysis algorithm to evaluate the differential infiltration levels of immune cell types between ITP patient and control. Molecular subtypes were identified based on the expression of hub genes. The expression of hub genes in the ITP patients was validated using quantitative real-time polymerase chain reaction analysis. This study identified five hub genes (ADH4, CYP7A1, CYP1A2, CYP8B1, and NR1H4), which were be associated with the pathogenesis of ITP, and two molecular subtypes of ITP. Among these hub genes, CYP7A1 and CYP8B1 involved in cholesterol metabolism,were further verified in clinical samples.
The investigators have designed a simple and user-friendly swallowing rehabilitation training method called "systematic simple swallowing training" based on commonly used swallowing training techniques in the department of rehabilitation medicine and the prevalent pathological causes of swallowing disorders in the elderly. It has shown promising preliminary efficacy. The goal of this clinical trial is to explore the impact of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals (≥60 year old) with swallowing disorders. It primarily aims to address two key aspects: 1) the prevalence of dysphagia among community-dwelling elderly individuals, and 2) the effects of systematic simple swallowing training on swallowing function and quality of life in community-dwelling elderly individuals with swallowing disorders. All participants are divided into 2 groups. The intervention group is required to undergo a continuous three-week (21 days) systematic simple swallowing training, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 15-20 minutes each.