anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Injection of the tibiotalar (TT) joint is commonly performed in clinical practice under ultrasound (US) guidance using an anteromedial approach. However, in some patients, this approach may be technically challenging due to post-traumatic and/or degenerative bony changes. Therefore, the aim of this cadaveric investigation was to demonstrate the feasibility of the ultrasound-guided (USG) injection of the ankle joint via the anterolateral sulcus (ALS) by confirming the dye placement/distribution inside the articular space. Likewise, the safety of the procedure has also been evaluated by measuring the distance between the needle and the intermediate dorsal cutaneous nerve of the foot.
DESIGN: A descriptive laboratory study with eight embalmed cadaveric ankles using the Fix for Life (F4L) method was performed at the setting of an academic institution. The interventional technique and the related anatomical findings were illustrated. During the injection, the needle was advanced into the TT joint through the ALS under US guidance, i.e., in-plane anterior-to-posterior approach. With the objective to confirm its correct placement, the needle was kept in situ and-to demonstrate the location of the dye inside the articular space-all eight ankles were injected with 3 mL of green color dye. Thereafter, a layer-by-layer anatomical dissection was performed on all four cadavers.
RESULTS: The position of the needle's tip within the ALS was confirmed in all specimens. Accurate placement of the dye inside the articular space of the ankle was confirmed in seven of the eight cadaveric ankles, with 87.5% of accuracy. Herewith, unintentional spilling of the dye within the superficial soft tissues was reported in two of the eight ankles (25.0%). The mean distance between the needle and the intermediate dorsal cutaneous nerve of the foot, measured in all eight procedures, was 3 cm.
CONCLUSION: USG injection of the ALS using the in-plane, anterior-to-posterior approach can accurately place the injectate inside the articular space.
CLINICAL RELEVANCE: This cadaveric investigation described the accuracy and potential pitfalls of USG injection of the ankle via the anterolateral approach which represents an alternative technique in patients with reduced accessibility of the anteromedial recess due to degenerative and/or post-traumatic bony changes.
N5 Sensors has developed a device that can measure chemical concentrations at parts-per-billion levels (for example, 10 molecules in one-billion molecules is 10 parts-per-billion). This device will be used to measure a variety of chemicals in the exhaled breath of human volunteers. The measured chemicals have been selected based on their presence in the breath of subjects with COVID infection. In addition to measuring breath, samples of mucus from the nose of these same subjects will be collected. These nasal samples will be evaluated to determine the presence of the COVID virus and of COVID infection. Changes in chemicals in the breath will be compared to the presence of COVID or to infection with COVID. This comparison will determine if measurement of breath can be used as a quick and simple measure of COVID infection.
In a storing unit of a medical image processing apparatus, first 3D image corresponding to a first period and second 3D image data corresponding to a second period are stored. The first 3D image data corresponds to a period before contrast agent injection operation and/or therapeutic operation. The second 3D image data corresponds to a period after the contrast agent injection operation and/or therapeutic operation. A 3D subtracting unit subtracts the first 3D image data from the second 3D image data. In 3D subtraction image data, a portion having undergone a change due to contrast agent injection operation and/or therapeutic operation is emphasized. A pseudo 3D image data generating unit generates pseudo 3D image data on the basis of 3D subtraction image data. A displaying unit displays the pseudo 3D image data.
Patients undergo reduced dose ISRT once daily (excluding weekends) over 3 treatment fractions. Patients also undergo CT or PET/CT throughout the study. Patients may additionally undergo endoscopy during screening and during follow up.
Oral vancomycin is used in treating antibiotic-associated pseudomembranous colitis caused by C. difficile and for staphylococcal enterocolitis. Vancomycin is not effective by the oral route for other types of infections. The usual adult total daily dosage is 500 mg to 2 g given in 3 or 4 divided doses for 7 to 10 days. The total daily dose in children is 40 mg/kg of body weight in 3 or 4 divided doses for 7 to 10 days. The total daily dosage should not exceed 2 g. The appropriate dose may be diluted in 1 oz of water and given to the patients to drink. Common flavoring syrups may be added to the solution to improve the taste for oral administration. The diluted solution may be administered via a nasogastric tube.
Impaired motivated behaviors, including aspects of decision-making and reward-related processes, lie at the root of maladaptive behavior in many psychiatric disorders, including major depression (MD). Little is known of the cognitive and neural mechanisms that underlie MD in adolescents. Adolescence is a key period during which many psychiatric disorders first emerge, and studies during this developmental stage may provide a unique window to address primary deficits associated with the disorders. In particular, major depression shows a marked increase in prevalence at adolescence. Data from family-based and longitudinal studies suggest that anxiety disorders (AD), often preceding MD, may index childhood vulnerabilities for the development of MD. The concomitant examination of MD and AD can help interpret these findings. We propose to examine, in adolescents, the manner in which the various elemental emotional-cognitive processes are differentially affected in MD and AD compared to healthy controls. This investigation will be done in two phases. In Phase I, using fMRI, we will test two tasks in the decision-making model of gambling that have similarly been tested in adults in a group of healthy adolescents and healthy adults. This phase will serve as a test of the feasibility and validity of using these tasks in adolescents, and will provide normative developmental data by comparing healthy adults with healthy adolescents. In addition to showing the feasibility of using these tasks in normal adolescents, we will also test task performance behaviorally in healthy, anxious and depressed adolescents. Measures will include psychophysiological and eye tracking measures, and behavioral variables. Once task performance is well characterized behaviorally, we will conduct in Phase II an fMRI study in independent groups of depressed and anxious adolescents and compare the findings with those obtained in healthy adolescents.
BACKGROUND: To combat the opioid epidemic, several strategies were implemented to limit the unnecessary prescription of opioids in the postoperative period. However, this leaves a subset of patients who genuinely require additional opioids with inadequate pain control. Deep learning models are powerful tools with great potential of optimizing health care delivery through a patient-centered focus. We sought to investigate whether deep learning models can be used to predict patients who would require additional opioid prescription refills in the postoperative period after elective surgery.
METHODS: This is a retrospective study of patients who received elective surgical intervention at the Mayo Clinic. Adult English-speaking patients ≥18 years old, who underwent an elective surgical procedure between 2013 and 2019, were eligible for inclusion. Machine learning models, including deep learning, random forest, and eXtreme Gradient Boosting, were designed to predict patients who require opioid refills after discharge from hospital.
RESULTS: A total of 9,731 patients with mean age of 62.1 years (51.4% female) were included in the study. Deep learning and random forest models predicted patients who required opioid refills with high accuracy, 0.79 ± 0.07 and 0.78 ± 0.08, respectively. Procedure performed, highest pain score recorded during hospitalization, and total oral morphine milligram equivalents prescribed at discharge were the top 3 predictors for requiring opioid refills after discharge.
CONCLUSION: Deep learning models can be used to predict patients who require postoperative opioid prescription refills with high accuracy. Other machine learning models, such as random forest, can perform equal to deep learning, increasing the applicability of machine learning for combating the opioid epidemic.
To date, an important challenge that clinicians hare facing in the assessment and diagnosis of intermittent claudication is that pathologies associated with vascular or neurogenic claudication can coexist in the same patient. Differentiation between both origins can be difficult due to variable signs and symptoms which can be atypical.

The first aim of this study was to elaborate and validate a treadmill walking test that would help discriminate between neurogenic claudication from vascular claudication. The second objective of this study is to determine if the treadmill walking test can discriminate spinal stenosis from low back pain with radiating pain in lower limb. 60 participants (20 with spinal stenosis, 20 with peripheral artery disease and 20 with non-specific low back pain) will be recruited. Participants will be invited to walk on a treadmill at a speed of 1,2 mph for a maximum of five minutes for both tasks (straight walking posture and inclined walking posture). Each walking task will be followed by a rest time of five minutes in sitting position. It is hypothesized that walking time difference for the occurrence of pain and for pain relief will be sensitive and specific to pathologies and help to discriminate lumbar spinal stenosis.
A system and method determines priority and presents heterogeneous medical data. The method includes retrieving medical data of a patient, the medical data including data from a plurality of data sources. The method includes phenotyping the medical data to generate a clue of reasoning and a reasoning result including one or more codes, the clue of reasoning including determining a basis for the reasoning result. The method includes assigning a relevance score to each of the one or more codes. The method includes ordering the codes based on the relevance score for each of the one or more codes. The method includes displaying the codes in a sorted order.
Metadoxine Immediate-release/slow-release, bilayer tablet PO of 1400 mg, taken once daily for 10 weeks.; alternative name: MG01CI.
The present disclosure relates to a method for configuring a medical device. The method comprises: providing a set of one or more parameters for configuring the medical device. Each parameter of the set has predefined values. A set of values of the set of parameters may be selected from the predefined values. Using the selected values the set of parameters may be set, which results in an operational configuration of the medical device. The medical device may be controlled to operate in accordance with the operational configuration, thereby an operating status of the medical device may be determined. Based on at least the operating status the operational configuration may be maintained or the selecting, setting and controlling may be repeatedly performed until a desired operating status of the medical device can be determined based on the operating statuses resulting from the controlling.
A micro-particle structure including a compound containing bitter melon, lemon verbena, and roselle for decreasing weight and body fat is provided in the disclosure. The micro-particle structure includes a core body and an exterior structure body. The exterior structure body from the inside thereof includes an encapsulation body and a protective layer. The encapsulation body encapsulates the core body. The protective layer has a membrane-shaped structure, encapsulating the encapsulation body. The micro-particle structure can decrease the accumulation of the fat. Besides, it can be added to any drinks or food ingredients, contributed to the property of the solubility in the water and the oil, and it can also maintain the activity of the nutrient composition it encapsulates.
A carrying device is provided. The carrying device is used for carrying a film roll having a first side and a second side opposite to the first side. The carrying device includes a base, a first frame, a second frame, a first airbag, a second airbag, a third airbag and a fourth airbag. The first frame is disposed on the base and has a first penetrating portion. The second frame opposite to the first frame is disposed on the base and has a second penetrating portion. The first airbag is disposed on the first penetrating portion and is used for holding one end of the film roll, and the second airbag is disposed on the second penetrating portion and is used for holding another end of the film roll. The third airbag is disposed on the first frame and is opposite to the first side, and the fourth airbag is disposed on the second frame and is opposite to the second side.
In an 18-month carcinogenicity study in CD-mice, salmeterol at oral doses of 1,400 mcg/kg and above (approximately 20 times the MRHDID for adults and children based on comparison of the plasma AUCs) caused a dose-related increase in the incidence of smooth muscle hyperplasia, cystic glandular hyperplasia, leiomyomas of the uterus, and ovarian cysts. No tumors were seen at 200 mcg/kg (approximately 3 times the MRHDID for adults and children based on comparison of the AUCs).

In a 24-month oral and inhalation carcinogenicity study in Sprague Dawley rats, salmeterol caused a dose-related increase in the incidence of mesovarian leiomyomas and ovarian cysts at doses of 680 mcg/kg and above (approximately 66 and 35 times the MRHDID for adults and children, respectively, on a mcg/m2 basis). No tumors were seen at 210 mcg/kg (approximately 20 and 10 times the MRHDID for adults and children, respectively, on a mcg/m2 basis). These findings in rodents are similar to those reported previously for other beta-adrenergic agonist drugs. The relevance of these findings to human use is unknown.

Salmeterol produced no detectable or reproducible increases in microbial and mammalian gene mutation in vitro. No clastogenic activity occurred in vitro in human lymphocytes or in vivo in a rat micronucleus test. 

Fertility and reproductive performance were unaffected in male and female rats at oral doses up to 2,000 mcg/kg (approximately 195 times the MRHDID for adults on a mcg/m2 basis).
Each patient will receive 4 separate Coxsackievirus A21 (CVA21) administrations in the first 8 days on trial (Days 1, 3, 5 and 8), followed by a fifth dose 2 weeks later (Day 22) and further administrations at 3 weekly intervals (Days 43, 64, 85, 106 and 127, up to a maximum of 10 sets of injections) until confirmed disease progression or development of excessive toxicity. Subjects with stable disease or better at Day 127 were eligible to receive up 9 more sets of CVA21 administrations under an extension protocol (VLA-008).
Pregnancy Category C. Embryo/fetal development studies were conducted in rats (dosed from day 6 to day 17 of gestation) and rabbits (dosed from day 7 to day 20 of gestation). Administration of fosamprenavir to pregnant rats and rabbits produced no major effects on embryo-fetal development; however, the incidence of abortion was increased in rabbits that were administered fosamprenavir. Systemic exposures (AUC0-24 hr) to amprenavir at these dosages were 0.8 (rabbits) to 2 (rats) times the exposures in humans following administration of the maximum recommended human dose (MRHD) of fosamprenavir alone or 0.3 (rabbits) to 0.7 (rats) times the exposures in humans following administration of the MRHD of fosamprenavir in combination with ritonavir. In contrast, administration of amprenavir was associated with abortions and an increased incidence of minor skeletal variations resulting from deficient ossification of the femur, humerus, and trochlea, in pregnant rabbits at the tested dose approximately one-twentieth the exposure seen at the recommended human dose.

The mating and fertility of the F1 generation born to female rats given fosamprenavir was not different from control animals; however, fosamprenavir did cause a reduction in both pup survival and body weights. Surviving F1 female rats showed an increased time to successful mating, an increased length of gestation, a reduced number of uterine implantation sites per litter, and reduced gestational body weights compared with control animals. Systemic exposure (AUC0-24 hr) to amprenavir in the F0 pregnant rats was approximately 2 times higher than exposures in humans following administration of the MRHD of fosamprenavir alone or approximately the same as those seen in humans following administration of the MRHD of fosamprenavir in combination with ritonavir.

There are no adequate and well-controlled studies in pregnant women. LEXIVA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. 

Antiretroviral Pregnancy Registry: To monitor maternal-fetal outcomes of pregnant women exposed to LEXIVA, an Antiretroviral Pregnancy Registry has been established. Physicians are encouraged to register patients by calling 1-800-258-4263.
BACKGROUND: Coagulation factor XI deficiency is an autosomal recessive hereditary disease with a low incidence. It usually occurs after surgery or trauma; Esophageal cancer is a common malignant tumor of the digestive tract in China. But so far, surgery-based comprehensive treatment of esophageal cancer still dominates.
CASE PRESENTATION: We report a case of an Asian patient with XI factor deficiency and lower esophageal squamous cell carcinoma who was admitted to our hospital recently. After active preoperative preparation, the operation was successfully performed, and there was no obvious abnormal bleeding during and after the operation.
CONCLUSIONS: Coagulation factor XI deficiency is a relatively rare disease, and patients with the disease will face a greater risk of bleeding during the perioperative period. The encouraging perioperative outcome enables us to have a deeper understanding of surgical treatment strategies for patients with Coagulation factor XI deficiency.
The accumulating evidence has made it clear that iron overload is a crucial mechanism in bone loss. Protocatechualdehyde (PCA) has also been used to prevent osteoporosis in recent years. Whether PCA can reverse the harmful effects of iron overload on bone mass in aged rats is still unknown. Therefore, this study aimed to assess the role of PCA in iron overload-induced bone loss in senile rats. In the aged rat model, we observed that iron overload affects bone metabolism and bone remodeling, manifested by bone loss and decreased bone mineral density. The administration of PCA effectively mitigated the detrimental effects caused by iron overload, and concomitant reduction in MDA serum levels and elevation of SOD were noted. In addition, PCA-treated rats were observed to have significantly increased bone mass and elevated expression of SIRT3,BMP2,SOD2 and reduced expression of TNF-α in bone tissue. We also observed that PCA was able to reduce oxidative stress and inflammation and restore the imbalance in bone metabolism. When MC3T3-E1 and RAW264.7 cells induced osteoblast and osteoclasts differentiation, PCA intervention could significantly recover the restriction of osteogenic differentiation and up-regulation of osteoclast differentiation treated by iron overload. Further, by detecting changes in ROS, SOD, MDA, expression of SIRT3 and mitochondrial membrane potentials, we confirm that the damage caused to cells by iron overload is associated with decreased SIRT3 activity, and that 3-TYP have similar effects on oxidative stress caused by FAC. In conclusion, PCA can resist iron overload-induced bone damage by improving SIRT3 activity, anti-inflammatory and anti-oxidative stress.
The present disclosure is related to process for the extraction of bioactive compounds, mainly dicapheoilquinic acid from natural products such as Flourensia cernua (leafen) leaves using non-conventional hybrid methodologies (ultrasound and microwave). By means of this type of unconventional extraction methodologies, the use of polluting solvents is reduced, time is reduced and the obtaining of compounds is optimized. On the other hand, the use of natural resources is promoted, such as the leaf to give the same added value. Through this method, dicapheoilquinic acid obtained from natural products such as Flourensia cernua leaves is recovered. The molecule has bioactive potential and exhibits a potent antioxidant capacity estimated by ABTS, DPPH and FRAP tests. The dehydration, milling, extraction method, purification and recovery of dicapheoilquinic acid and its characterization and identification by mass spectrometry are presented. The dicapheoilquinic acid obtained by this method can be used in different areas such as food, chemical, pharmaceutical, biomedical, cosmetic, among others.
A sonic energy reactor for handling a stream of fluid consists of a horn having a length of an integral number of 1/2 wavelengths, said horn having a sonic input and a sonic output for longitudinal vibration. About a nodal region of the horn is an external, integral mounting flange. Associated with the horn is a fitting having at least three pipe stubs extending from a fitting body with the stub interiors communicating with a chamber within the fitting body for fluid flow between stubs. At least one of the stubs is sufficiently large to permit the horn portion between the horn output end and the mounting flange to be inserted into said one stub interior, the relative dimensions being such that the free end of such horn constituting the sonic energy output end reaches a desired location in the chamber in the fitting body interior. The free end of said one pipe stub is shaped to cooperate with the horn mounting flange and additional parts for providing a detachable coupling between the horn and fitting. This detachable coupling includes among other things a gasket of sonic energy insulating means such as rubber for inhibiting the escape of sonic energy from the horn to the fitting and to contain the fluid. Sonic energy discharged at the output end of the horn is effective to act upon material flowing past the horn portion for sonic energy irradiation. The remaining stubs of the fitting are adapted to function as fluid flow inlets and outlets and if sufficient stubs are available, may accommodate additional horns for irradiation. All stubs are detachably coupled to fluid feed pipes or one or more ultra-sonic horns. Such a construction permits ready assembly and/or disassembly of all components constituting the reactor and horn assembly permitting cleaning, sterilization and visual examination for observing the amount of physical wear of said horn output end. By controlling the relative dimensions of a fitting pipe stub and horn, the relative disposition of the output end of a horn within a fitting chamber may be controlled for the purpose of subjecting fluid particles to compression, tension and/or shear, the latter depending upon the relative shapes of the surfaces of horn and fitting interiors. By selecting appropriate materials, usually metals such as stainless steel, titanium and utilizing standardized and accepted fittings available in the market, a sonic energy reaction device may be available for use in food treatment processes, cosmetics, drugs, corrosive chemicals and various other fields where standard or special fittings are available.
A randomized, double-blinded, placebo-controlled, 14-day multiple ascending dose (MAD) study in healthy male and/or female subjects each. Subjects will receive placebo sc for 14 days.