anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a peptide for promoting skin repair, a preparation method and application thereof, and relates to the technical field of polypeptide skin repair. Which comprises a polypeptide having the amino acid sequence shown in SEQ ID NO. 1. The polypeptide has the characteristics of good dispersibility, stable acid-base environment, low production cost and the like. Rationality based on the hydrophobic amino acid ratio design allows for uniform dispersion of the skin repair promoting peptide in aqueous and lipid materials. The skin repair promoting peptide has the functions of promoting skin repair, promoting collagen expression, resisting oxidation and the like, and can be applied to the fields of preparing medicines for repairing body surface wounds, repairing burns, repairing skin ulcers, reducing skin repair caused by scars, accelerating the repair of scars and the like, and preparing regenerative cosmetics and skin care cosmetics.
Vertebrate scavenging on human remains is occasionally observed at indoor forensic scenes, especially when pets have access to the body and their deceased owners were socially distanced. Pets feeding on corpses have implications for the forensic investigation, e.g. for trauma analysis and the assessment of the cause of death, the estimation of the postmortem interval (PMI), or the recovery of the complete set of remains. Documentation of potential scavenging in forensic practice is tenuous and needs to be improved in order to be able to use the information for future casework. Investigators need to be aware of the alterations pets can cause to human remains and how these affect further analyses. Following a combined literature review for cat and canine scavenging, we present seven new cases from Switzerland with cat and/or dog involvement. We then created a flowchart guide for a systematic collection of data to use at indoor forensic scenes of suspected scavenging. Our literature review revealed the challenge in discriminating between scavenging by domestic cats and dogs, based on the appearance of the lesions alone. Furthermore, the information that is often routinely collected in indoor fatalities with potential scavenging activity is not sufficient to perform this separation. To provide a practical basis for cat and canine scavenging and its differentiation, we summarise strategies and present a flowchart to use in forensic casework of suspected indoor scavenging.
Continuation of VPA for up to 96 weeks. As of 05/20/08 this step was discontinued.
ETHNOPHARMACOLOGICAL RELEVANCE: Zhilong Huoxue Tongyu Capsule (ZL) is clinically prescribed for acute ischemic stroke (AIS). However, only a few studies have addressed the mechanisms of ZL in treating AIS.
AIM OF THE STUDY: To explore the underlying mechanism of macrophage polarization and inflammation mediated by ZL, and to provide a reference for AIS treatment.
MATERIALS AND METHODS: Sixteen SD rats were fed with different dose of ZL (0, 0.4, 0.8, and 1.6 g/kg/d) for 4 days to prepare ZL serum. After 500 ng/mL lipopolysaccharide (LPS) stimulation, RAW264.7 cells were administrated with ZL serum. Then, experiments including ELISA, flow cytometry, real-time quantitative PCR and Western blot were performed to verify the effects of ZL on macrophage polarization and inflammation. Next, let-7i inhibitor was transfected in RAW264.7 cells when treated with LPS and ZL serum to verify the regulation of ZL on the let-7i/TLR9/MyD88 signaling pathway. Moreover, the interaction between let-7i and TLR9 was confirmed by the dual-luciferase assay.
RESULTS: ZL serum significantly decreased the expression of interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and increased the expression of IL-10 and transforming growth factor β1 (TGF-β1) of LPS stimulated-macrophages. Furthermore, ZL serum polarized macrophages toward M2, decreased the expressions of TLR9, MyD88, and iNOS, as well as increased the expressions of let-7i, CHIL3, and Arginase-1. It is worth mentioning that the effect of ZL serum is dose-dependent. However, let-7i inhibitor restored all the above effects in LPS stimulated-macrophages. In addition, TLR9 was the target of let-7i.
CONCLUSIONS: ZL targeted let-7i to inhibit TLR9 expression, thereby inhibiting the activation of the TLR9/MyD88 pathway, promoting the M2 polarization, and inhibiting the development of inflammation in AIS.
NEW MATERIAL:A compound expressed by formula I (R is 1-10C alkyl which may be substituted by alkenyl, aryl, cyano, OH alkoxycarbonyl or aminocarbonyl) and salt thereof. EXAMPLE:2-Methylthio-1-(2-pyridylmethyl)benzimidazole. USE:A remedy for peptic ulcer having inhibitory effect on gastric acid secretion and protective action on gastric mucosae with low toxicity. PREPARATION:For example, an imidazole derivative expressed by formula II is reacted with 2-picolyl chloride expressed by formula III in the presence of a base, e.g. sodium hydride, etc., in an organic solvent, e.g. DMF, etc., at room temperature - 80 deg.C to give a sulfide compound in the compound expressed by formula I. the resultant compound is then reacted with one equivalent oxidizing agent, e.g. m-chloroperbenzoic acid, etc., in a solvent to afford the aimed sulfinyl compound. When the aobve-mentioned sulfide compound is reacted with 2 equivalents oxidizing agent, the aimed sulfonyl compound is obtained.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to chemical-pharmaceutical, food and cosmetic industry, namely creating a herbal agent with a wide spectrum of action. A method for making an oil includes the following stages: Cucurbita maxima Dich or Cucurbita pepo Z or Cucurbita moschata (Dich) Poir seeds prepared by deintoxication, decortication and decontamination by steaming are humidified at the first stage of expression by dropping with transferring with the use of a screw conveyor to moisture 10-12%; then seeds are pressed with self-heating to 70-75C; it is followed by the second stage of expression by feeding broken seeds with the use of the screw conveyor which involves seed cooling to temperature 20-25C and drying to moisture 6-7% that is followed by pressing; the oils prepared at the first and second stages are combined, filtered, settled to temperature 20C and finally filtered. The prepared oil represents a greenish brown liquid with specific odour and flavour. The liquid is easily soluble in chloroform, hexane and diethyl ester; its density makes 0.88 to 0.94, an acid value is 1.25 and less, an iodine value ranges within 100 to 140; the a-tocopherol content exceeds 4 mg %. ^ EFFECT: prepared oil is a high-effective agent applicable in various industries. ^ 5 cl, 1 ex, 1 tbl
OBJECTIVE: This study aims to evaluate the effectiveness of gentamycin irrigation in preventing postoperative surgical site infection (SSI) in emergency neurosurgical procedures.
METHODS: A total of 518 consecutive emergency neurosurgeries, including craniotomies, endoscopic and burr hole procedures were reviewed retrospectively. Patients received either only normal saline (NS) irrigation or NS irrigation with gentamycin added (80 mg/L) during the whole process of surgery. SSIs including wound infection and intracranial infection were the primary outcome. SSI was considered while purulence was observed during wound dressing and confirmed with bacterial culture of wound exudation. In addition, positive result of bacterial growth culture of cerebrospinal fluid was also considered as infection. Infection rates were calculated 28 days after surgery. Statistical analysis was performed using t test or Chi-squared test where appropriate.
RESULTS: This study included 444 patients. Gentamycin was used in 179 (40.3%) patients. Only 2 (1.1%) of 179 patients receiving gentamycin irrigation had an infection. However, among the other 265 patients receiving only NS irrigation, the infection rate was 8.3%. With the addition of gentamycin, the infection rate was decreased by 86.7% (P = 0.001). The two infected patients in gentamycin group were compromised postoperatively: one patient had removed his own extraventricular drainage tube accidentally due to restlessness, and the other had severely contaminated his wound with vomitus during the intracranial drainage tube removal process. If these two patients were excluded from analysis, the effective infection rate using gentamycin irrigation is 0%.
CONCLUSION: The gentamycin plus NS irrigation during emergency neurosurgical procedures can lead to a significantly lower rate of postoperative infection than when NS is used alone.
Diabetes Mellitus (DM) is defined as a state of hyperglycemia, in either fasting or postprandial states. DM is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both . Type 2 diabetes mellitus (T2DM) is one of these diseases and it is characterized by insulin resistance . The International Diabetes Federation (IDF) estimates that the global prevalence of diabetes mellitus is 366 million in 2011 and expects an increase to 552 million in 2030. In this sense, the increase in the DM prevalence, especially in T2D, has become one of the major problems in modern society \[5\]. In this regard, this chronic disease is connected with the increase of obesity prevalence \[6\] and the high levels of physical inactivity \[5\] in people with T2DM.

Peripheral neuropathy is one of the most common complications and consequences of chronic hyperglycemia . This is characterized by a progressive degeneration that primarily affects the small-diameter cutaneous nociceptive fibers. Diabetic patients encounter impaired balance, proprioception loss and decreased ROM. Physical exercise has become a therapy for people with T2DM , improving physical fitness , quality of life, and autonomic modulation ; as well as enhancing metabolic control and insulin sensitivity; and reducing inflammatory markers and neuropathy symptoms . Interestingly, physical activity could also increase the regenerative capacity of cutaneous axons, slowing or preventing neuropathy progression .

Exercises based on whole-body vibration (WBV) training have shown to enhance balance, mobility muscle strength, pain, cardiorespiratory fitness, and bone density, in both healthy and clinical populations. In this regard, a recent systematic review and meta-analysis (with a total of seven studies, involving 279 older adults with T2DM) focused on the effects of WBV determined that this training improved the mobility, balance and aerobic capacity without any known adverse effects. Moreover, WBV could have positive effects on glycemic indices or body composition. Regarding glycemic indices, a previous study showed that acute WBV decreases the glucose level in elderly women with T2DM. However, the effects of WBV intervention on glycosylated hemoglobin (HbA1c) is uncertain. Tai Chi exercise program which is actually a form of proprioceptive and balance training helps in reduction of fall and balance issues and also beneficial for the pain reduction in osteoarthritic patients.

Basic TC exercise is a mind-body exercise composed of a series of refined motions linked together as a rhythmical sequence in which the body is continuously shifting with low center of gravity from one foot to the other. These exercises can help in training of dual task performance as the practitioner's eye focuses on the leading arm and the mind focuses on the breath and movement sequences. It also improves cardiovascular endurance, aerobic capacity and quality of life and reduces stress
For assessment of fluid status, a commercial portable BIA device (InBody M20®, InBody Corp., Seoul, Korea) was measured. Baseline BIA data were collected at the time of ICU admission, and BIA measurements were performed daily for 3days for all participants. The participants in active fluid management with BIA monitoring arm received fluid supplementation targeting specific range of ECW ratio by BIA (0.390-0.406). If a patient with dehydrated status indicated by the ECW ratio was less than 0.390, a bolus infusion was performed using 250ml of crystalloid fluid (PlasmaLyte). If a patient with overhydrated status indicated by the ECW ratio was more than 0.406, 10mg of furosemide was administered. Changes in the ECW ratio were measured at one hour after initial intervention for fluid adjustment, and the investigators determined whether additional intervention was needed according to results of changes. These processes continued until the ECW ratio was within the normal range (0.390-0.406).
AIM: Patients with osteoporosis who also have sarcopenia are at a high risk for falls and fractures. Early detection of sarcopenia is crucial for these patients. This study aimed to compare the effectiveness of SARC-F, SARC-CalF, and calf circumference (CC) as screening tools for sarcopenia in patients with osteoporosis.
METHODS: This cross-sectional study was retrospectively conducted on patients who attended the outpatient clinic for Osteoporosis and Sarcopenia at Kyoto Medical Center. Sarcopenia was determined based on low skeletal muscle mass and weak handgrip strength. Sensitivity and specificity analyses were conducted on SARC-F, SARC-CalF, and CC. The diagnostic utility of these three tools was compared using the receiver-operating characteristic (ROC) curves and the area under the ROC curves (AUC).
RESULTS: A total of 225 patients (men/women: 33/192) with a median age of 69.0 years (interquartile range: 61.0‒75.0) were enrolled. The prevalence of sarcopenia was found to be 11.6%. CC had the highest sensitivity (80.8%), while SARC-F had the highest specificity (93.0%) for detecting sarcopenia. ROC analysis revealed that all three tools had significant potential for sarcopenia diagnosis, with SARC-CalF having the highest AUC compared to SARC-F and CC (0.753 vs. 0.619 and 0.700). A multivariate logistic regression, incorporating other confounders as explanatory variables, revealed that SARC-CalF was independently related to sarcopenia (odds ratio: 14.80, 95% confidence interval: 3.83-57.30, p < 0.001).
CONCLUSION: In patients with osteoporosis, SARC-CalF is more effective in the early detection of sarcopenia than SARC-F and CC.
It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal (cisternal or lumbar) route exhibit different cellular tropisms in the central nervous system. Thus, a subject can be treated by injection into the CSF of ssAAV or scAAV vector encoding a therapeutic protein, such as an ssAAV9 or scAAV9 vector. The therapeutic protein can be targeted to specific cells using these vectors. In some embodiments, scAAV9 is utilized to achieve superior transduction in the hippocampus, cerebellum and cerebral cortex where both neurons, particularly Purkinje neurons, and glial cells (such as astrocytes) are transduced. In other embodiments, ssAAV9 is utilized to minimize transduction of astrocytes. In further embodiments, an immunosuppressive agent is also administered to the subject.
Subjects in Arm 2 will not take any antibiotics prior to the meal challenge. They will consume a challenge meal of ultra-processed foods.
INTRODUCTION: Platelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone. Furthermore, platelets trigger acute inflammation and cardiac remodeling leading to alterations in scar formation and cardiac function as observed in thrombocytopenic mice. GPVI is the major collagen receptor in platelets and important for platelet activation and thrombus formation and stability. Antibody induced deletion of GPVI at the platelet surface or treatment of mice with recombinant GPVI-Fc results in reduced inflammation and decreased infarct size in a mouse model of AMI. However, the role of GPVI has not been fully clarified to date.
METHODS/RESULTS: In this study, we found that GPVI is not involved in the inflammatory response in experimental AMI using GPVI deficient mice that were analyzed in a closed-chest model. However, reduced platelet activation in response to GPVI and PAR4 receptor stimulation resulted in reduced pro-coagulant activity leading to improved cardiac remodeling. In detail, GPVI deficiency in mice led to reduced TGF-β plasma levels and decreased expression of genes involved in cardiac remodeling such as Col1a1, Col3a1, periostin and Cthrc1 7 days post AMI. Consequently, collagen quality of the scar shifted to more tight and less fine collagen leading to improved scar formation and cardiac function in GPVI deficient mice at 21d post AMI.
CONCLUSION: Taken together, this study identifies GPVI as a major regulator of platelet-induced cardiac remodeling and supports the potential relevance of GPVI as therapeutic target to reduce ischemia reperfusion injury and to improve cardiac healing.
Nicotine withdrawal symptoms (e.g., increased negative affect, decreased positive affect, cigarette craving) are a core component of cigarette dependence that emerge upon the absence of nicotine administration, maintaining cigarette smoking and inhibiting cessation efforts. The use of electronic cigarettes (e-cigarettes) has increased dramatically in recent years, with studies demonstrating that e-cigarettes can reduce nicotine withdrawal symptoms during acute cigarette abstinence. E-cigarettes with flavorings that simulate the sweet taste of fruit, candy and other sugary foods and beverages are widely available, commonly used and are frequently cited as a reason for the persistent use of e-cigarettes. During nicotine withdrawal, sweet flavors have been shown to reduce nicotine withdrawal symptoms. Additionally, a recent USC TCORS (Tobacco Center of Regulatory Science) administrative supplement study conducted at the University of Southern California (USC) Health, Emotion, and Addiction Laboratory (USC-HEAL) found that sweet-flavored solutions enhanced the appeal of e-cigarettes, independent of nicotine. However, the impact of e-cigarette flavorings on nicotine withdrawal symptoms is currently unknown. This behavioral pharmacology laboratory experiment will assess whether sweet (vs. non-sweet) flavored e-cigarette solutions reduce tobacco withdrawal symptoms and motivation to smoke among 40 smokers interested in trying e-cigarettes (for the first time) following 16-hours of nicotine abstinence. At each visit, participants will complete a standardized e-cigarette administration procedure, as developed in our prior work, in which flavor will be manipulated in a double-blind, cross-over, counterbalanced design. Following the e-cigarette administration, participants will complete: 1) self-report measures of nicotine withdrawal symptoms; 2) physiological measurements and 3) a behavioral task that measures participants' ability to resist the desire to resume smoking under conditions in which it is advantageous to remain abstinent (i.e., monetary payment for each successive 5-min increment in which smoking is delayed). The study's experimental design will provide evidence of the causal effects of e-cigarette flavorings on a putatively critical factor for determining whether smokers continue e-cigarette use after initial trial-the ability of a product to suppress withdrawal and motivation to smoke during periods of tobacco deprivation.
After successful screening the cases of cirrhosis of liver irrespective of the etiology who have non tumor portal vein thrombosis will be enrolled. The baseline Doppler parameter will be recorded and the patient will be randomized into either interventional (warfarin) or control (aspirin) group. From postoperative day 3, patients in interventional (warfarin) group will receive oral Warfarin 2.5mg qd with titration of dose to maintain a target INR of 2-3 for 1 year, patients in control (aspirin) group will receive oral Aspirin Enterie Ccoated Tablets 100mg qd for 1 year, and both groups will be along with five days of subcutaneous injection of Low Molecular Weight Heparin and three months of oral Dipyridamole. Every 3 months the Doppler screening for the occurrence of portal vein thrombus (PVT) or spleno-mesenteric thrombosis will be done for all patients. Both groups will receive the therapy for one year irrespective of the Doppler findings in relation to portal vein thrombus occurrence. Then one year monitoring will be done in the both groups as per the primary or secondary outcome.
A therapeutic composition comprises chlorophyll in therapeutically effective amount and a promoter distributed in a carrier, the chlorophyll used being separated, at least in part, from the materials with which it is associated in plants. Specified promoters are sulphonamides having bacterial properties, namely sulphanilamide, sulphathiazole, sulphagrunidine, 5-carboxy sulphathiazole, sulphadiazine, sulfamerazine, and sulphapyridine; the following acids and esters: propyl para hydroxy-benzoate, methyl para hydroxy benzoate, para amino benzoic acid, methyl para amino benzoate, n-propyl para-amino benzoate, n-amyl para amino benzoate, as well as urea and alloxan; antibiotics, namely penicillins and esters thereof, streptothrycin, bacitracin, streptomycin and their salts; dyes having antiseptic properties, namely malachite green, acriflavin, gentian violet, acriviolet, 2,7-di bromo 4-hydroxymercuri-fluorescein, sodium ethyl mercurithio salicylate; carotinoids and xanthophylls; vitamins A, B, complex, C, D, E (  tocopherol) K and inositol; gonadotropic hormone, androgenic hormones and stilboestrol; naso-constictors such as epinephrin, ephedrine and desoxyephedrine; pepsin, trypsin and lysozyme.  Fluid preparations may be prepared by dissolving water-soluble chlorophylls such as sodium metal chlorophyllin, where metal denotes magnesium, copper or iron, in physiological saline solution or by dispersing water-insoluble chlorophylls, as such or dissolved in oil, in acqueous meda such as physiological saline solution with the aid of emulsifying or dispersing agents such as certain waxes, ursolic acid, oils and fats, glyceryl or glycol fatty acid esters and soaps such as sodium oleate, alkaline metal salts of sulphuric acid esters of long chain alcohols or magnesium, calcium or zinc oleates.  For more viscous preparations oil or fat soluble chlorophyll and oils such as liquid paraffin, cotton seed oil, olive oil, linseed oil, linoleic acid, soyabean oil and eucalyptus oil may be employed with or without the addition of a still more viscous material.  Ointments may be prepared with a basis of bland non-irritating materials such as lanoline, lard, aquaphor (mainly eucerin, which comprises a mixture of esters of iso-or oxy-cholesterol alcohols with principally oleic, carnaubic and myristic acids), petrolatum, monolene (propylene glycol stearate), cholesterols, stearic acid, palmitic acid and other higher and lower fatty acids and alcohols and their esters such as triacetin, glyceryl stearate, glyceryl palmitate and glyceryl oleate.  One or more of the promoters specified above may be admixed with one or more carrier materials to provide compositions of desired therapeutic activity and for consistency.  Glycerin, pectin or gum may also be added.  Powders may be prepared with a talcum base.