anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Implantable capsule comprises; (a) an external envelope consisting of a hydrogel of acrylonitrile and sodium methallylsulphonate, and (b) an internal centre comprising the encapsulated substance. Pref., capsule is spherical and has a dia. of 800-900 micron. Envelope has constant thickness of 100 micron. The encapsulated substance can consist of Islets of Langerhans or beta pancreatic cells, in which case the envelope is permeable to insulin and to nutrients required for encapsulated substance. The encapsulated substance can be hepatocytes. USE/ADVANTAGE - Cell transplantation, partic. transplantation of Islets of Langerhans to diabetics. The capsule is impermeable to agents of immune system, but permeable to nutrients and secreted insulin. Encapsulated substance is viable and functional. Capsule is biocompatible and has no unfavourable reaction with adjacent tissue, thus reducing possibility of rejection.
The present invention discloses a qinbei granules preparation for curing cough in children and a preparation method thereof. The qinbei granules preparation is composed of ephedrae, scutellaria root, ussuriensis fritillary bulb, fried mulberry bark, peucedanum root, stemona root, radix adenophorae, stiff silkworm, liquorice, beta-cyclodextrin and cane sugar powder. The medicine has the preparation method that ephedrae, fritillary bulb, peucedanum root, stemona root and white mulberry root bark are extracted twice by ethanol, and each time for reflux extraction is 2 hours. Decoction liquid is merged and filtered to obtain extractum, and beta-cyclodextrin is proportionally added, stirred and packaged for use. Scutellaria root, ladybell root and liquorice are decocted with water and extracted twice, and each time is extracted for 2 hours by adding water. The decoction liquid is merged, filtered, decompressed and concentrated to obtain paste. The paste and the spare paste are merged, uniformly mixed, and dried in a spray mode to obtain spray powder. Cane sugar powder is proportionally added, uniformly mixed and palletized in a dry mode. The medicine which is suitable for children to take has the functions of antivirus, relief of cough, elimination of phlegm, relief of asthma and antiinflammation.
Local anaesthetics for injection comprise an acid salt of an anaesthetic, epinephrin or an equivalent vaso-constrictor, an antioxidant, and a buffer salt so that the solution has a pH value between 5,7 and 7,0.  In some cases an acid also is added. The preparations may be prepared as stable solutions or as dry mixtures to be dissolved in water.  Sodium chloride may be added to give an isotonic solution.  The specific gravity should be above 1,0093, preferably it should be 1,011 or more. According to one example the solution contains procaine hydrochloride, disodium phosphate, di-hydrogen potassium phosphate, sodium chloride, sodium bisulphite, phosphoric acid, and epinephrin.  The phosphates and phosphoric acid in this mixture, serving as buffers, may be replaced by sodium and potassium tartrates with tartaric acid; or the acetates with acetic acid; or the citrates with caustic soda and hydrochloric acid; or disodium phosphate with nitric acid; or mono-, di-, and tri-sodium phosphate with potassium acid phosphate and phosphoric acid; or carbonates of sodium, potassium, and calcium with hydrochloric acid. Nitrate or sulphate of procaine may be used in place of the hydrochloride.
PURPOSE: Spinal epidural hematoma (SEH) is a rare yet significant complication associated with neuraxial anesthesia. Here, we present the case of a 74-yr-old male who underwent open repair of an abdominal aortic aneurysm. Following the removal of an epidural catheter, the patient developed anterior spinal cord syndrome due to an SEH despite having a normal coagulation profile.
CLINICAL FEATURES: This patient's neurologic presentation was marked by a loss of motor function while maintaining fine touch sensation distal to the spinal cord injury. Initial truncal computed tomography (CT) angiography failed to detect vascular compromise or diagnose the SEH. Subsequently, delayed magnetic resonance imaging (MRI) revealed a multilevel thoracic epidural hematoma, spinal cord infarction, and ischemia. Immediate surgical decompression was performed, but unfortunately, the patient had a poor outcome.
CONCLUSION: Anterior spinal cord syndrome (ASCS) represents an uncommon neurologic manifestation of SEH, which is typically characterized by a triad of back pain and sensory and motor deficits. Although the initial CT scan was necessary to diagnose the postvascular surgery complication, it did not immediately detect the SEH. In cases of ASCS subsequent to thoracic epidural placement and removal, MRI is the preferred imaging modality for precise diagnosis and assessment of the need for surgical intervention. Despite adherence to anticoagulation guidelines, patients undergoing neuraxial anesthesia may face an elevated risk of developing SEH. Health care professionals should remain vigilant in monitoring for neurologic abnormalities following epidural catheter insertion or removal, particularly in the context of vascular surgery.
A computer-implemented method for sharing information and managing diabetes diagnosis and treatment. The method comprises providing a web portal account accessible by both a patient and health care provider. The account may be associated with a portable medical device. The method includes receiving, at one or more servers, medical and usage data from the portable medical device. The medical data may be associated with the patient and the usage data may be associated with usage of the medical device by the patient. Statistics related to the medical or usage data are accumulated at one or more servers over a period of time, and may be accessible in the web portal account. The method includes evaluating the statistics in relation to a treatment criteria, and sending a treatment recommendation to the patient or the health care provider when at least one of the statistics meets or exceeds a predetermined treatment criteria.
Human papillomavirus (HPV) is a circular, double-stranded DNA virus and recognized as the most prevalent sexually transmitted infectious agent worldwide. The HPV life cycle encompasses three primary stages. First, the virus infiltrates the basal cells of the stratified epidermis. Second, there is a low-level expression of viral genes and preservation of the viral genome in the basal layer. Lastly, productive replication of HPV occurs in differentiated cells. An effective immune response, involving various immune cells, including innate immunity, keratinocytes, dendritic cells, and natural killer T cells, is instrumental in clearing HPV infection and thwarting the development of HPV-associated tumors. Vaccines have demonstrated their efficacy in preventing genital warts, high-grade precancerous lesions, and cancers in females. In males, the vaccines can also aid in preventing genital warts, anal precancerous lesions, and cancer. This comprehensive review aims to provide a thorough and detailed exploration of HPV infections, delving into its genetic characteristics, life cycle, pathogenesis, and the role of high-risk and low-risk HPV strains. In addition, this review seeks to elucidate the intricate immune interactions that govern HPV infections, spanning from innate immunity to adaptive immune responses, as well as examining the evasion mechanisms used by the virus. Furthermore, the article discusses the current landscape of HPV vaccines and common treatments, contributing to a holistic understanding of HPV and its associated diseases.
The invention belongs to the technical field of microbial preparations, and particularly relates to a lactobacillus strain composition for improving chronic kidney diseases and application thereof. The technical problem to be solved by the invention is to provide a microbial composition which has the effects of reducing uremic toxins (uremic toxins) and precursors thereof and slowing down renal tissue lesions to improve chronic kidney disease (chronic KIDNEY DISEASE, CKD) and promote renal function. The technical scheme of the invention is a lactobacillus strain medical composition for improving chronic kidney disease, which comprises a lactobacillus strain mixture and a pharmaceutically acceptable carrier; the lactobacillus strain mixture comprises Lactobacillus acidophilus (Lactobacillus acidophilus) PCo-96, lactobacillus casei (Lacticaseibacillus casei) ZE-2, bifidobacterium longum subsp. Infantis (Bifidobacterium longum subsp. Infantis) BR631 and Streptococcus salivarius thermophilus (Streptococcus salivarius subsp. Thermophilus) host-06. The lactobacillus strain composition of the invention provides a new choice for improving chronic kidney disease or maintaining kidney function.
Provided are: a novel marker useful for measuring hypoxia or predicting the exacerbation of pathoses related to hypoxia; a hypoxia measurement method and a pathosis exacerbation prediction method which use said marker as an indicator; a composition for measuring hypoxia or predicting the exacerbation of pathoses; a method for screening a therapeutic agent for pathoses related to hypoxia; and a composition for ameliorating hypoxia-related pathoses. This method for measuring hypoxia in a subject or this method for predicting the exacerbation of pathoses comprises a step for measuring the amount of SPINK1 in a sample collected from the subject. This use of SPINK1 as a biomarker is for measuring hypoxia or for predicting the exacerbation of pathoses. This composition for measuring hypoxia or predicting the exacerbation of pathoses contains a SPINK1 detection agent. This method for screening a therapeutic agent for pathoses related to hypoxia uses, as an indicator, the fact that a candidate substance can inhibit SPINK1. This composition for ameliorating hypoxia-related pathoses contains a SPINK1 inhibitor.
OBJECTIVE: To determine whether elderly women (≥65 years) have an increased risk of complications and lower success when undergoing laparoscopic sacrocolpopexy (LSC) compared with younger women (<65 years).
METHODS: This was a retrospective study of all LSC procedures performed from August 2014 to February 2021 by a single urogynecologic surgeon in an academic affiliated hospital system. Charts were identified through procedure codes. Patient demographics, clinical, surgical, and postoperative data were collected. The primary outcome of this study was to compare complications associated with LSC, including intraoperative and postoperative complications. Secondary outcomes included subjective, objective, and composite success.
RESULTS: In total, 312 participants met the criteria. The mean age of the group who were younger than 65 years was 55.7 years (±6.5) and of the group aged 65 years or older was 69.3 years (±3.5). Racial demographics revealed no differences between the two groups. Patients aged 65 years or older had a statistically significant lower body mass index (calculated as weight in kilograms divided by the square of height in meters), a higher rate of hypertension, smaller genital hiatus, and a larger anterior vaginal wall prolapse compared with the younger cohort. They also less often underwent a posterior repair. No statistically significant differences were found with regards to intraoperative and postoperative complications, including 30-day re-admission, between the two age groups. Both groups had high anatomic success rates, with no significant difference (<65 = 96.3%; ≥65 = 98.4%; P = 0.326). Those aged younger than 65 years compared with those aged 65 years or older had lower subjective success that was not significantly different (<65 = 62.8%; ≥65 = 71.0; P = 0.134). Composite success was noted to reach the threshold of a statistically significant difference in the group aged younger than 65 years compared with those aged 65 years or older (60.1% vs 71.0%; P = 0.0499).
CONCLUSION: In this study, elderly patients did not have increased intraoperative and postoperative complications after undergoing LSC. Similar rates of anatomic and subjective success were also found with younger patients having a lower composite success. Proper candidates for LSC should not be excluded based upon age.
BACKGROUND: Although CDKN2A alteration has been explored as a favorable factor for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) and intragenic deletion (DEL) and response to immune checkpoint inhibitors (ICIs) is still disputed. This study aims to determine the associations of CDKN2A MUT and DEL with overall survival (OS) and response to immune checkpoint inhibitors treatment (ICIs) among pan-cancers and the clinical features of CDKN2A-altered gastric cancer.
METHODS: This study included 45,000 tumor patients that underwent tumor sequencing across 33 cancer types from four cohorts, the MSK-MetTropism, MSK-IMPACT, OrigiMed2020 and TCGA cohorts. Clinical outcomes and genomic factors associated with response to ICIs, including tumor mutational burden, copy number alteration, neoantigen load, microsatellite instability, tumor immune microenvironment and immune-related gene signatures, were collected in pan-cancer. Clinicopathologic features and outcomes were assessed in gastric cancer. Patients were grouped based on the presence of CDKN2A wild type (WT), CDKN2A MUT, CDKN2A DEL and CDKN2A other alteration (ALT).
RESULTS: Our research showed that CDKN2A-MUT patients had shorter survival times than CDKN2A-WT patients in the MSK MetTropism and TCGA cohorts, but longer OS in the MSK-IMPACT cohort with ICIs treatment, particularly in patients having metastatic disease. Similar results were observed among pan-cancer patients with CDKN2A DEL and other ALT. Notably, CDKN2A ALT frequency was positively related to tumor-specific objective response rates to ICIs in MSK MetTropism and OrigiMed 2020. Additionally, individuals with esophageal carcinoma or stomach adenocarcinoma who had CDKN2A MUT had poorer OS than patients from the MSK-IMPACT group, but not those with adenocarcinoma. We also found reduced levels of activated NK cells, T cells CD8 and M2 macrophages in tumor tissue from CDKN2A-MUT or DEL pan-cancer patients compared to CDKN2A-WT patients in TCGA cohort. Gastric cancer scRNA-seq data also showed that CDKN2A-ALT cancer contained less CD8 T cells but more exhausted T cells than CDKN2A-WT cancer. A crucial finding of the pathway analysis was the inhibition of three immune-related pathways in the CDKN2A ALT gastric cancer patients, including the interferon alpha response, inflammatory response, and interferon gamma response.
CONCLUSIONS: This study illustrates the CDKN2A MUT and DEL were associated with a poor outcome across cancers. CDKN2A ALT, on the other hand, have the potential to be used as a biomarker for choosing patients for ICI treatment, notably in esophageal carcinoma and stomach adenocarcinoma.
The present invention relates to an external used hair growing preparation and a manufacturing method thereof. External used water agent or tinctures are formed by that propolis and right amount of water or ethanol are prepared according to the prior art. Compared with the prior art, the present invention has the advantages of simple construction, easy manufacturing method, low productive cost, easy control of product quality. The hair growing effects of products are better when the products are used by combining with another oral administration product applied by the applicant of the present invention. The products are used by more than one hundred thousand patients who all achieve the hair growing effects. When the products are used, new hairs can grow only if hair follicles are existent no matter whether alopecia is caused by various reasons.
Atrazine (ATR), a water-soluble herbicide commonly used to control broad-leaf and monocotyledonous weeds, presents a significant risk to environmental soil and water quality. Exposure to ATR adversely affects human and animal health, frequently resulting in cardiac impairment. Curcumin (Cur), an acidic polyphenol derivative from plants acclaimed for its pronounced anti-inflammatory and antioxidant properties, has garnered interest as a potential therapeutic agent. However, whether it has the potential to ameliorate ATR-induced cardiac toxicity via modulation of endoplasmic reticulum stress (ERS) and apoptosis pathways in mice remains unclear. Our results showed that Cur supplementation attenuates ATR-induced cardiotoxicity, evidenced by decrease in creatine kinase and lactate dehydrogenase, key biochemical markers of myocardial injury, which have a more significant protecting effect in high-dose ATR induced injury. Histopathological and electron microscopy examinations further solidified these findings, demonstrating an amelioration in organellar damage, particularly in endoplasmic reticulum swelling and subsequent mitochondrial impairment. Additionally, ATR exposure augments ERS and triggers apoptotic pathways, as indicated by the upregulation of ERS-related gene expression (ATF6, CHOP, IRE1, GRP78) and pro-apoptotic markers (BAX, BAK1, Caspase3, Caspase. Intriguingly, Cur counteracts this detrimental response, significantly reducing ERS and pro-apoptotic signals at both transcriptional and translational levels. Collectively, our findings illuminate Cur's cardioprotective effect against ATR-induced injury, primarily through its anti-ERS and anti-apoptotic activities, underscoring Cur's potential as a therapeutic for ATR-induced cardiotoxicity.
FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to ophthalmology. To conduct corneal collagen crosslinking in the experiment, the cornea is treated with a solution of 0.1 % riboflavin for 30 minutes, the cornea is irradiated and its surface is wetted during the irradiation process with this solution every 2 minutes. Cornea is irradiated by a femtosecond laser with a wavelength of 525 nm. For this purpose, the human donor cornea is placed in an artificial anterior chamber, the central zone of the cornea is irradiated with a laser in the form of a straight circular cylinder 4 mm in diameter, 1 mm high, the upper base of which is the central zone of the cornea, and the longitudinal axis of the cylinder coincides with the optical axis of the eye. Set of identical layers is formed with a distance between them of 10 microns, the plane of which is perpendicular to the longitudinal axis of the cylinder. Each layer is formed from voxels located 2 mcm apart from each other in one row in height. Each voxel is an elliptical cylinder, the longitudinal axis of which lies in the plane of the layer, the major axis of the base perpendicular to the plane of the layer. In each layer, the longitudinal axes of the voxels of one layer are shifted by 90 degrees relative to the longitudinal axes of the voxels of the next layer.EFFECT: method increases the density of the cornea structure and its ability to resist stretching due to the cross-linking of collagen fibers.1 cl, 1 dwg, 1 ex
Healthy subjects received rosuvastatin 20 mg orally for 3 weeks. Inflammatory markers measured pre and post rosuvastatin treatment.
The present invention discloses heparinase I fusion protein and encoding genes and an expression method thereof. The heparinase I fusion protein provided by the present invention is protein having an amino acid residue sequence of SEQ ID No. 2 in a sequence table or protein which has the same activity as that of the amino acid residue sequence of the SEQ ID No. 2, is derived from the SEQ ID No. 2 and is formed by means that the amino acid residue sequence of the SEQ ID No. 2 is replaced, deleted or added by one or a plurality of amino acid residues. The present invention is characterized in that more than 90% of the heparinase exists in escherichia coli in the modes of activity and correct folded soluble protein. The heparinase activity can achieve 270 U/L in fermentation liquid (108UL <-1> OD<600><-1>), and the content of the protein can achieve 150 mg/L. In addition, the single step purification of the fusion protein is realized by compatible separation. The present invention can be widely used for producing the heparinase I.
In the context of this work the pain of different groups of patients should be examined by means of the painDetect Questionnaire, the Roland-Morris disability questionnaire, clinical examinations and different imaging procedures. Two groups of patients are compared with each other. Group one consists of patients with osteoporotic fractures of the vertebra. Group two is formed by patients with osteochondria , spinal disc herniation and nerval compression. Both groups of patients undergo surgery, as they are suffering from pain (e.g. kyphoplasty, nucleotomy, spondylodesis, decompression). In order to differentiate between chronic nociceptive pain and chronic neuropathic pain in these two groups the painDetect questionnaire is used. To examine the severity of disability in the patients' everyday life the Roland-Morris Disability questionnaire is used.

The included patients are examined and seen preoperative, postoperative before discharge from hospital, 6 weeks and 6 months after surgery.
An object is to provide an anorectic agent, a diet method and an appetite suppressing apparatus with which one can suppress appetite properly without physical or metal burdens or excessive efforts and without any detrimental side effect and can lose weight safely and healthily. 
     An anorectic agent contains an aqueous solvent extract of Vernonia cinerea as an active ingredient, or preferably contains aqueous solvent extracts of Vernonia cinerea and mulberry as active ingredients. The liquid content of the anorectic agent is evaporated so that a dieter can inhale its vapor. The active ingredients are odorless. They are not absorbed into the body through digestive organs if taken orally, but can be taken directly into blood through respiratory organs such as lungs and nose mucous membrane. The active ingredients then acts on the central nervous system, thereby causing the dieter to lose appetite and thus lose weight. This effect does not appear in a person who does not want to lose weight.
OBJECTIVES: To assess the intra/inter-observer reliability of cystoscopic sphincter evaluation (CSE) in men undergoing sling surgery for urinary incontinence and if possible to evaluate its correlation with the final clinical decision.
PATIENTS AND METHODS: Two expert urologists prospectively filmed and recorded, incontinent patient's cystoscopies according to a standard scenario. Anonymised recordings where randomly offered to the same observer twice. The observers (medical students, urology residents and full urologist with 0-5, 5-10, >10 years of practice, respectively) were asked to assess and score the recordings without knowing any of the patients' characteristics.
RESULTS: In total, 37 recordings were scored twice by the 26 observers. The intraclass correlation coefficient (ICC) for intra-observer reliability of the CSE was 0.54 (moderate), 0.58 (moderate) and 0.60 (substantial) for medical students, residents, and urologists, respectively. However, when stratifying observers according to their experience, the lowest agreement values were found between experts with >10 years of experience. The inter-observer reliability for the CSE ICCs ranged between 0.31and 0.53, with the lowest ICC value observed between urologists (0.31).
CONCLUSIONS: The study demonstrates poor intra- and inter-observer reliability of the CSE. According to these results, a CSE does not add valuable information to the clinical evaluation. In this scenario, it should not be considered in isolation from the patient's characteristics.