anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Headaches are a common condition affecting 47% of the global population,1,2 with cervicogenic headaches (CGHs) accounting for 15-20% of all chronic and recurrent headaches. The International Headache Society has classified a cervicogenic headaches as a secondary headache with 'pain referred from a source in the neck and perceived in one or more regions of the head and/or face. In the case of cervicogenic headache, the cause is a disorder of the cervical spine and its component bone, disc and/or soft tissue elements. The term cervicogenic headache is commonly misused and does not simply apply to a headache associated with neck pain; many headache disorders, including migraine and tension-type headache, can have associated neck pain/tension. Rather, there must be evidence of a disorder or lesion within the cervical spine or soft tissues of the neck, known to be able to cause a headache (1). It is often worsened by neck movement, sustained awkward head position or external pressure over the upper cervical or occipital region the symptomatic side (2). The prevalence of Chronic headache has been reported to be between 0.4 and 20 % of the headache population (3). In recent years, there has been an increasing knowledge in the pathogenesis and better management of chronic headaches.

Current scientific evidence supports the role of manual therapies in the management of tension type and cervicogenic headache (4). Individuals with Chronic headache are frequently treated with spinal manipulative therapy including both mobilization and manipulation. Spinal mobilization consists of slow, rhythmical, oscillating techniques (5) Cervical sustained natural apophyseal glides (SNAGs) are 'mobilization with movement' technique in which a sustained accessory facet glide is applied together with active physiological movement. The therapist may apply the glide over the spinous process (central SNAGs) or over the articular pillar on one side (unilateral SNAGs). SNAGs have been advocated for the treatment of neck pain and range of movement (ROM) restriction. SNAGs have been shown to be effective for the treatment of neck pain, cervicogenic headaches, and cervicogenic dizziness (6).mobilization with movement utilize the dual role of bot therapist force (accessory glides) and patient effort (active physiological or functional movement) and techniques are often carried out in a variety of weight bearing positions, with treatment belts, and either additional therapist, assistant or patient applied overpressure A thorough clinical examination is performed and appropriate level is identified, the glide is then performed parallel to the perceived facet plane and the degree of glide is determined by patient's active movement response (8). Many studies on the short-term effectiveness and manual therapy to the cervical spine (mobilization and manipulative therapy) have found it beneficial in reducing headache pain or disability, intensity, frequency, and duration.
Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or an alkenyl, alkynyl. cycloalfcyl. optionally substituted cycloalkcnyl or phenyi radical, or an optionally aromatic 5- or 6-membered heterocyclic radical; and Z is a hydrogen atom or a radical of general formula (II). wherein RI is an optionally substituted benzoyl. thenoy! or furoyl radical or a radical Rs-O-CO-. where R: is an alkyl, alkenyL alkynyl. cycloalkyl, cycloalkenyl. bicycloalkyl, optionally substituted phcnyl. or hetcrocyclyl radical, and Rj is an aromatic heterocyclic, alkyl. alkcnyl. alkynyl, cycloalkyl, phenyi or naphthy! radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkablc antimoral activity.
Our approach will be to test the impact of a behavioral intervention through a smartphone application, emWave software, which will be provided to all our subjects. The intervention (emWave) is a tool that reduces stress by allowing individuals to be less reactive, think clearly, and make good decisions, especially under pressure. Fifty medical residents with high burnout symptoms will be randomized to receive an 8-week intervention.
Placebo pill will be administered (po, pill by mouth) every other day starting at week 0 of the study in men diagnosed with low testosterone. Treatment will be delayed in these men until the 3 month completion of the study, at which time this group may also receive testosterone replacement therapy.
The invention provides a calculation method for quantitatively evaluating the capacity of storing acoustic characteristics of hearing transient from the psychological acoustic angle and the binaural correlation change processing mechanism in hearing perception. The model firstly sets the left ear and right ear noise signals to be tested, adopts the noise stimulus of an independent segment irrelevant to the ear between the two ear noise signals as target sound, then introduces delay clues between the ears, and combines a psychophysics method to quantitatively evaluate and measure the hearing instantaneous acoustic feature storage capacity of a tested person. First, the length values of the fixed inter-binaural independent segments are at several values at different levels, and the binaural delay threshold values at which the subject is able to perceive the intermediate independent segments at each level value are measured. The inter-binaural delay is then fixed at several values at different levels, and the time length threshold limit at which the individual segments can be perceived by the subject under each binaural delay value condition is measured. And finally, analyzing and fitting the data through experimental data of each tested person acquired under the two control conditions to obtain a quantitative evaluation result of the capacity of the tested person for instantaneously storing acoustic characteristics in hearing. The method is based on human auditory perception and psychoacoustic models, and better embodies the processing process of the auditory center in the initial processing stage. The method is simple to operate, and the evaluation result has accuracy and stability. The calculation result can intuitively show the time dynamic characteristic of the instantaneous energy storage capacity of the auditory system in the initial stage.
PURPOSE: A sphingosine activating agent and a skin therapeutic agent containing the same are provided to promote synthesis of spingosine-1-phosphate and recover injured skin function. CONSTITUTION: A therapeutic agent for treating skin scar, wrinkle, atopic dermatitis, or psoriasis contains sphingosine kinase as an active ingredient. The activating agent of sphingosine kinase contains at least one compound among compounds of chemical formulas 1 to 8. The activating agent of sphingosine suppresses cell proliferation in keratinocytes and promotes differentiation. In addition, the agent promotes cell proliferation and collagen synthesis in fibroblasts. The therapeutic agent is used in the form of toner, lotion, cream, essence, pack, powder, ointment, suspension, emulsion, spray, soap, shampoo, or gel.
In a recent placebo-controlled, double-blind, multicenter study of Secretin in refractory schizophrenics, we found that a patient who received Secretin (1.0 g/kg) intravenously, showed a marked improvement in eye blink conditioning following infusion. This subject also showed a clinical improvement of \> 20% on the Total Score and Total Negative Score of the Positive and Negative Syndrome Scale (PANSS). Therefore, the primary objective of this study is to confirm and extend this observation in a larger group of individuals with schizophrenia. In this 24 to 48 hour experiment, the acquisition and extinction of the conditioned blink response will be assessed in participants with schizophrenia who are randomly assigned to one of two double blind treatment groups: (1) subcutaneous saline or (2) subcutaneous Secretin (20 ug/kg). Enrolled participants will remain on their stable medication regime (i.e., psychotropic medications and related treatments will not be manipulated). Furthermore, given evidence that Secretin administration increases the amygdala's activation during experimental presentation of fear-related facial cue stimuli, we wish to also investigate the effects of the experimental agent on psychophysiological processes putatively related to amygdala function. Prepulse inhibition is a widely studied paradigm in the schizophrenia literature, thought to reflect disruption of early sensory-motor gating that is present in both individuals with schizophrenia and their unaffected biological relatives, and can be mediated by various limbic structures including the amygdala. Therefore, as a secondary aim, the effects of Secretin will be tested on affect modulation, pre-pulse inhibition, and pre-pulse facilitation of the acoustic startle response using common psychophysiological research procedures. These procedures are frequently used in our laboratory and are currently approved for our use by the IRBs at both IUPUI and IUB.
People with overweight and obesity tend to both underreport dietary energy intake and experience weight stigma. This exploratory pilot study aimed to determine the relationship between weight bias and weight stigma and energy intake reporting accuracy. Thirty-nine weight-stable adults with BMI ≥ 25 completed three 24 h dietary recalls; indirect calorimetry to measure resting metabolic rate; a survey measuring weight stigma, psychosocial constructs, and physical activity; and a semi-structured qualitative interview. Multiple linear regression was used to determine if weight bias internalization, weight bias toward others, and experiences of weight stigma were predictive of the accuracy of energy reporting. A thematic analysis was conducted for the qualitative interviews. Weight stigma was reported by 64.1% of the sample. Weight stigma constructs did not predict the accuracy of energy intake reporting. People with obesity underreported by a mean of 477 kcals (p = 0.02). People classified as overweight overreported by a mean of 144 kcals, but this was not significant (p = 0.18). Participants reported a desire to report accurate data despite concerns about reporting socially undesirable foods. Future research should quantify the impact of weight stigma on energy reporting in 24 h recalls using a larger, more diverse sample size and objective measures like doubly labeled water for validation.
The invention relates to an oxygen supply method for a gymnasium, which comprises the following steps: i, an information acquisition device and an oxygen outlet are arranged at the position of the fitness equipment. And II, acquiring and storing the basic information of the exerciser at the time point when the exerciser starts to use the exercise machine. The basic information includes facial features and health indications of the exerciser. And III, regularly acquiring real-time information of the exerciser in the whole using process of the exercise machine, wherein the real-time information comprises the face characteristics and the health signs of the exerciser. And IV, comparing the health indication in the real-time information with the health indication in the basic information after the real-time information in the step III is acquired each time. And V, adjusting the oxygen outlet flow of the oxygen outlet according to the comparison result in the step IV. The oxygen supply device directly supplies oxygen to the body builder through the oxygen outlet, adjusts the oxygen flow through the health indication, has high oxygen supply precision, can avoid the oxygen deficiency condition of the body builder and can also avoid waste caused by ineffective oxygen supply.
This study examines the effects of vision training on the sportive performance of professional wrestlers. In wrestling, rapid decision making, timely opponent detection and effective execution of strategic moves are highly dependent on visual perception skills. In this context, our study investigated how vision training improves wrestlers' sportive performance and neck proprioception.

Before the study, ethical approval was obtained from Marmara University Faculty of Medicine Ethics Committee with the number 09.2022.1084. The study was started with 28 athletes from the Turkish Greco-Roman A National Team and was carried out on 27 athletes after one athlete in the control group was injured. The athletes who were examined by an ophthalmologist before the study, who did not have any visual problems and who did not have a history of surgical operation and / or injury that would adversely affect the balance in the last 6 months were randomly divided into 2 groups. The 14-member vision training group was subjected to a vision training program that included eye exercises accompanied by a physiotherapist for 5 sessions per week in addition to their routine training for 8 weeks, while the control group continued their routine training. Performance measurements were performed in both groups at the beginning of the study, in the middle of the training (week 4.), at the end of the training (week 8.) and 4 weeks after the training (week12.). Performance evaluations; Wrestling Specific Shuttle Run, Squat-Bench Press Maximum Strength, The Mc-Gill Endurance (Flexion, Extension and Lateral Plank Endurance Tests), Pro-agility Agility, Stork Static Balance, Star Dynamic Balance (Anterior, Posterolateral and Posteromedial directions) and Neck Proprioception tests (cervical region flexion, extension, right lateral flexion, left lateral flexion, right rotation and left rotation). The measurement results were statistically evaluated both within and between groups. The effect of the training program on the visual training and control groups was compared in a time-dependent manner. The effect x time interaction was evaluated by ANOVA analysis.
Mean maximum blood concentrations (Cmax) in patients are achieved approximately 2 - 4 hours after administration of a single oral dose of frovatriptan 2.5 mg. The absolute bioavailability of an oral dose of frovatriptan 2.5 mg in healthy subjects is about 20% in males and 30% in females. Food has no significant effect on the bioavailability of frovatriptan, but delays tmax by one hour.

Binding of frovatriptan to serum proteins is low (approximately 15%). Reversible binding to blood cells at equilibrium is approximately 60%, resulting in a blood:plasma ratio of about 2:1 in both males and females. The mean steady state volume of distribution of frovatriptan following intravenous administration of 0.8 mg is 4.2 L/kg in males and 3.0 L/kg in females.

In vitro, cytochrome P450 1A2 appears to be the principal enzyme involved in the metabolism of frovatriptan. Following administration of a single oral dose of radiolabeled frovatriptan 2.5 mg to healthy male and female subjects, 32% of the dose was recovered in urine and 62% in feces. Radiolabeled compounds excreted in urine were unchanged frovatriptan, hydroxylated frovatriptan, N-acetyl desmethyl frovatriptan, hydroxylated N-acetyl desmethyl frovatriptan and desmethyl frovatriptan, together with several other minor metabolites. Desmethyl frovatriptan has lower affinity for 5-HT1B/1D receptors compared to the parent compound. The N-acetyl desmethyl metabolite has no significant affinity for 5-HT receptors. The activity of the other metabolites is unknown.

After an intravenous dose, mean clearance of frovatriptan was 220 and 130 mL/min in males and females, respectively. Renal clearance accounted for about 40% (82 mL/min) and 45% (60 mL/min) of total clearance in males and females, respectively. The mean terminal elimination half-life of frovatriptan in both males and females is approximately 26 hours.

The pharmacokinetics of frovatriptan are similar in migraine patients and healthy subjects.
Leukopenia and neutropenia have been reported during treatment with antipsychotic agents, including VRAYLAR. Agranulocytosis (including fatal cases) has been reported with other agents in the class. 

Possible risk factors for leukopenia and neutropenia include pre-existing low white blood cell count (WBC) or absolute neutrophil count (ANC) and history of drug-induced leukopenia or neutropenia. In patients with a pre-existing low WBC or ANC or a history of drug-induced leukopenia or neutropenia, perform a complete blood count (CBC) frequently during the first few months of therapy. In such patients, consider discontinuation of VRAYLAR at the first sign of a clinically significant decline in WBC in the absence of other causative factors.

Monitor patients with clinically significant neutropenia for fever or other symptoms or signs of infection and treat promptly if such symptoms or signs occur. Discontinue VRAYLAR in patients with absolute neutrophil count < 1000/mm3 and follow their WBC until recovery.
FIELD: cosmetics. SUBSTANCE: soap cream-mask has a complex bioactive substances: spirituous-aqueous-glycerol extract of sea buckthorn or complex CO 2 -extract from pot-marigold and millet flour, spirituous-aqueous-glycerol extract of hop or CO 2 -extract of fir. Extracts added to cream formula in combination with other components show softening, cleansing and antiinflammatory effect at pimpled (acne) rash. Cream-mask can be used in the case of fat and combined face skin as cleansing and antiinflammatory agent. EFFECT: enhanced quality of cream-mask. 7 tbl
The present invention is to remove inconvenience which is caused when data are individually stored in different kinds of devices. The current situation is such that a user is one but the user has to load different data from different servers by IoT device. For example, put the case that an IoT device is a device for collecting bio-information related to health care. In this case, a user has to open different applications to check all bio-information including blood pressure, blood sugar, and steps. In addition, when the user is not a medical expert, the user does not have an ability to examine and analyze separated data respectively, such that the data collected with difficulty becomes useless. To solve the problem, the present invention is to provide a method for examining data collected by IoT devices, including all bio-information of a user, through one application by meeting interface specifications required by a manufacturer server through an open API that is used by almost all manufacturers for IoT devices and receiving data from individual servers in a personal server of the user.
Body weight, body mass index (BMI), Nutrition Risk Screening 2002 (NRS2002), and prognostic nutritional index (PNI) are among vital nutrition status indices employed during cancer treatment. These have also been associated with levels of blood chemistry panels (BCPs), which are touted as significant indicators of disease prognosis. However, it remains unclear which nutrition status index better predicts future trends in specific BCPs. Using the records of 407 cancer patients, we retrospectively examined the potential of nutritional status indices at baseline for predicting changes in specific BCPs over a 6-week period. Generally, both serum biochemical parameters and nutrition status indices fluctuated over the study period among study participants. PNI was often linearly associated with blood cell counts (white blood cells [WBCs] and hemoglobin) compared with anthropometric-based nutrition status indices. Increase in body weight was protective against having abnormal lymphocyte levels at 6 weeks (odds ratio [OR]: 0.960-0.974; CI: 0.935-0.997; P < 0.05), while increase in baseline PNI was associated with 0.865-0.941 and 0.675-0.915 odds of having future abnormal WBC and lymphocyte levels, respectively. Increases in PNI were also protective against having future abnormal albumin levels (OR: 0.734-0.886) and 8.5-12.5% decreases in the odds of having an abnormal C-reactive protein level in subsequent visits. Changes in NRS2002 tended to be associated with the odds of having future abnormal blood glucose levels. In conclusion, the serum biochemistry-derived nutrition status index, PNI, is a more consistent measure as an early indicator to track the trends of future changes in the BCPs of cancer patients. This implies that PNI could be targeted as an early-warning measure with relevant preventive interventions for patients at risk of malnutrition.
Patients taking Huaier Granule for adjuvant treatment after the triple negative breast cancer has been surgically removed. The Huaier Granule (Qidong Gaitianli Medicines Co., Ltd.) should be given orally from the 3rd day after surgery up to 5 years after surgery or until study termination.
Teratogenic Effects: 

Teratology studies conducted in mice and rats at doses 4-times and 8-times, respectively, the dose of a 50 kg human given 10 mg/day (when based on surface area or mg/m2), demonstrated no embryotoxic or teratogenic effects due to naloxone hydrochloride. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, naloxone hydrochloride should be used during pregnancy only if clearly needed. 

Non-teratogenic effects:

Risk-benefit must be considered before naloxone hydrochloride is administered to a pregnant woman who is known or suspected to be opioid-dependent since maternal dependence may often be accompanied by fetal dependence. Naloxone crosses the placenta, and may precipitate withdrawal in the fetus as well as in the mother. Patients with mild to moderate hypertension who receive naloxone during labor should be carefully monitored as severe hypertension may occur.
The two stages of this pilot study consist of the following: single or double dose platelet apheresis collection, pathogen inactivation with INTERCEPT treatment, storage for 7 days, collection of fresh platelets, radiolabeling, infusion of fresh and stored INTERCEPT treated radiolabeled autologous platelets, and collection of blood samples for assessment of platelet recovery and survival (lifespan). In Stage 2, apheresis platelets will be collected using the Trima separator and stored for 7 days in 100% plasma.
The invention relates to a skin care cream made from snails and process for preparation, wherein the cream comprises ingredient A, B and C, the ingredient A includes snail secretion liquid 30-50 parts, snail ovums 20-40 parts, ingredient B includes hyaluronic acid 5-15 parts, deionized water 3-7 parts, the ingredient C includes xanthan gum 6-12 parts, edible flavoring essence 0. 3-0. 6 part, potassium sorbate 3-5. 5 part. The preparing process comprises the steps of mixing ingredient A, dispensing for 24 hours, heating ingredient B, agitating to 70 Deg. , pouring ingredient A into ingredient B, agitating for 2 hours, cooling down to 20 Deg, charging in ingredient C, agitating for one more hour.
PROBLEM TO BE SOLVED: To obtain the subject cell strain free from the trouble of inducing viral infection in transplantation and useful e.g. for the treatment of crystalline lens diseases such as cataract by imparting epithelium cell of crystalline lens with an infinite proliferation potency in vitro by a specific method without using the infection with live virus. SOLUTION: This cell strain is a monoclonal epithelium cell strain of human crystalline lens (SRA01/04 strain, etc.) having uniform property, capable of expressing an extrinsic immortalizing gene and established without using the infection with live virus e.g. by the transfection of an epithelium cell of human crystalline lens originated from epithelium of crystalline lens by a plasmid expression vector functionally integrated with an immortalizing gene. A heat- sensitive epithelium cell strain of human crystalline lens (SRA01/01 strain, etc.) terminating the proliferation within about 2 weeks at about >=36 deg.C and capable of stably continuing the proliferation at about 33 deg.C can be produced by transfecting with an expression vector containing an immortalizing gene expression cassette exhibiting temperature-sensitive expression behavior.