anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A cosmetic composition containing fermented Prunus mume siebold & zucc. root, leaf, and fruit extract is provided to improve a skin whitening effect. CONSTITUTION: A cosmetic composition for skin whitening contains fermented Prunus mume siebold & zucc. root, leaf, and fruit extract as an active ingredient. The extract is prepared by adding Prunus mume siebold & zucc. roots, leaves, and fruits together with rice straw and performing primary natural fermentation at 25-40 Deg. C. for 5-30 days; and a step of inoculating lactic acid bacteria to the extract and secondarily maturing and fermenting at 25-35 Deg. C. for 1-5 days. The primary natural fermentation is induced by Bacillus subtilis. The secondary fermentation is extracted using water, butylene glycol, propylene glycol, glycerin, or ethanol. The composition is manufactured in the form of a skin lotion, lotion, nutrition cream, massage cream, nutrition essence, eye cream, cleansing lotion, cleansing oil, cleansing cream, pack, or foundation.
The present invention is based on an efficient natural compounds chitin and tinosporin for the treatment of HIV, HTLV thereof. The invention emphasize specially on the application of compounds chitin and tinosporin which is acts as an immunomodulator. It increases innate immunity of the host where as tinisporin selectively inhibit virus from establishing infection to target t helper cells. The exact mechanism by which it prevent infection of virus and host cell is not known but on analysing from cell culture incubated with virus doesn't show any series activation of host cell it suggest either virus is not entering in to the cell or,after entry it could not get activated. The concentration of tinosporin for prevention is 10% isolated in to active form from its natural source. The concentration of chitin >20 um size for prevention is 10% solution base also plant lectins are added to boost up the effect. The remedy is effective against all type of retroviruses and other viruses which enters in to the cell via receptor binding and then cell entry mechanism. Another advantage of this drug is that it is very cost effective and not toxic because all the substance is of natural origin as comparative to existing drug which is toxic and expensive and not 100% effective too. The unique feature of invention is that it is the first natural fusion inhibitor for HIV or retroviruses and thus these compounds have no side effect.
The sirtuin (SIRT) family is well-known as a group of deacetylase enzymes that rely on nicotinamide adenine dinucleotide (NAD+). Among them, mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) are deacetylases located in mitochondria that regulate the acetylation levels of several key proteins to maintain mitochondrial function and redox homeostasis. Mitochondrial SIRTs are reported to have the Janus role in tumorigenesis, either tumor suppressive or oncogenic functions. Although the multi-faceted roles of mitochondrial SIRTs with tumor-type specificity in tumorigenesis, their critical functions have aroused a rising interest in discovering some small-molecule compounds, including inhibitors and activators for cancer therapy. Herein, we describe the molecular structures of mitochondrial SIRTs, focusing on elucidating their regulatory mechanisms in carcinogenesis, and further discuss the recent advances in developing their targeted small-molecule compounds for cancer therapy. Together, these findings provide a comprehensive understanding of the crucial roles of mitochondrial SIRTs in cancer and potential new therapeutic strategies.
669,120. Veterinary medicines. AMERICAN CYANAMID CO. July 18, 1949 [Oct. 6, 1948], No. 18845/49. Class 81 (i). A composition for the prevention and control of coccidiosis in members of the animal kingdom especially poultry comprises an edible or potable substance containing m,m-dinitrophenyl disulphide. The particle size of the disulphide is less than 100 micra. 0.005-0.06 per cent by wt. disulphide is used in feeds for prophylactic treatment, and 0.06 to 0.2 per cent by wt. of the disulphide in feeds for the treatment of established infection. The disulphide may be incorporated in the mash, cracked corn, wheat or other animal or poultry food, or may be added to the drinking water together with suitable solvents and/or suitable dispersing agents.
OBJECTIVE: Functional dysphonia can impair the language expression ability and adversely affect the career development of some patients. Therefore, an active exploration of effective treatment options is imperative. This study investigated the effect of Akson therapy on acoustic parameters in patients with functional dysphonia.
MATERIALS AND METHODS: In this retrospective analysis, 79 patients with functional dysphonia who received conventional voice correction training from June 2020 to June 2021 were included in the reference group (RG). Our hospital has implemented Akson therapy since July 2021. Correspondingly, 72 patients with functional dysphonia who underwent Akson therapy from July 2021 to July 2022 were enrolled in the observation group (OG). The acoustic parameters such as fundamental frequency (F0), jitter, shimmer, and normalized noise energy (NNE); the aerodynamic parameters including maximum phonation time (MPT), mean airflow rate (MFR), and Voice Handicap Index-10 (VHI-10) score; and the Grade, Roughness, Breathiness, Asthenia, and Strain scale (GRBAS) score were measured before and after treatment and compared between the two groups.
RESULTS: The F0, jitter, shimmer, NNE, MPT, and MFR values as well as the VHI-10 score and the grade (G), roughness (R), and breathiness (B) scores on the GRBAS did not significantly differ between the two groups before treatment (P > 0.05). However, significantly lower F0, jitter, shimmer, NNE, and MFR values and higher MPT levels were found in the OG compared to the RG after treatment (P < 0.001). Furthermore, the VHI-10 score and the G, R, and B scores were significantly lower in the OG than in the RG after treatment (P < 0.001), whereas the asthenia (A) and strain (S) scores remained at 0 before and after treatment.
CONCLUSION: Akson therapy can improve the acoustic parameters of patients with functional dysphonia to a certain extent, indicating its potential application value.
Coronary Heart Disease (CHD) remains a significant problem in the US, causing about 1 of every 5 deaths in 2005. In 2009, approximately 1.3 million Americans will have a new/recurrent myocardial infarction. Coronary heart disease (CHD) includes myocardial infarction, stable or unstable angina, demonstrated myocardial ischemia detected by noninvasive testing, and a history of coronary artery procedures (such a stent or bypass). Currently, "statins" are recommended by the AHA to manage elevated low-density lipoprotein-cholesterol (LDL-C). Unfortunately, the discontinuation of statins is quite substantial. For example, a large cohort study of older patients found that 2-year statin adherence rates were approximately 40% for acute coronary syndrome patients, 36% for chronic coronary artery disease, and 25% for primary prevention and is associated with increased mortality, hospitalizations, and costs. Recently, the kinesin 6 (KIF6) gene has been associated with a 30-55% increase in cardiovascular events in individuals carrying one or two risk variants (\~57% of the white population) in multiple prospective studies. Furthermore, KIF6 carriers receiving a "statin" have a substantial greater cardiovascular risk reduction (-34 to 50%) when using a "statin" compared to those that are non-carriers using a statin (6 to 20%). In this prospective, open label, trial, recruited subjects recently started on statin therapy will be provided information about their KIF6 carrier status and followed for 6 months to determine their "statin" adherence. Additionally, quality of life and factors adherence will be measured at baseline and after 6 months. Finally, pharmacy records will be evaluated for up to 1-year to determine statin discontinuation rates.
Pregnancy Category C. Reproduction studies have been performed for lidocaine in rats at doses up to 6.6 times the human dose and have revealed no evidence of harm to the fetus caused by lidocaine. There are, however, no adequate and well-controlled studies in pregnant women. Animal reproduction studies are not always predictive of human response. General consideration should be given to this fact before administering lidocaine to women of childbearing potential, especially during early pregnancy when maximum organogenesis takes place. Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.
Changes in the biomechanical and biochemical properties of the human cornea play an important role in the pathogenesis of ectatic diseases. A number of conditions in primarily acquired (keratoconus or pellucid marginal degeneration) or secondarily induced (iatrogenic keratectasia after refractive laser surgeries) ectatic disorders lead to decreased biomechanical stability. Corneal collagen cross-linking (CXL) represents a technique to slow or even halt the progression of ectatic pathologies. In this procedure, riboflavin is applied in combination with ultraviolet A radiation. This interaction induces the production of reactive oxygen species, which leads to the formation of additional covalent bonds between collagen molecules and subsequent biomechanical corneal strengthening. This procedure is so far the only method that partially interferes etiopathogenetically in the treatment of ectatic diseases that slows or stops the process of corneal destabilization, otherwise leading to the need for corneal transplantation. Besides, CXL process increases markedly resistance of collagenous matrix against digesting enzymes supporting its use in the treatment of corneal ulcers. Since the discovery of this therapeutic procedure and the first laboratory experiments, which confirmed the validity of this method, and the first clinical studies that proved the effectiveness and safety of the technique, it has been spread and adopted worldwide, even with further modifications. Making use of the Bunsen-Roscoe photochemical law it was possible to shorten the duration of this procedure in accelerated CXL and thus improve the clinical workflow and patient compliance while maintaining the efficacy and safety of the procedure. The indication spectrum of CXL can be further expanded by combining it with other vision-enhancing procedures such as individualized topographically-guided excimer ablation. Complementing both techniques will allow a patient with a biomechanically stable cornea to regularize it and improve visual acuity without the need for tissue transplantation, leading to a long-term improvement in quality of life.
The acyl-β-glucuronide metabolite of clopidogrel is a strong inhibitor of CYP2C8. Clopidogrel bisulfate can increase the systemic exposure to drugs that are primarily cleared by CYP2C8, thereby needing dose adjustment and appropriate monitoring.

Clopidogrel bisulfate increased repaglinide exposures by 3.9-fold to 5.1-fold [see Clinical Pharmacology ( 12.3)].  Avoid concomitant use of repaglinide with clopidogrel bisulfate. If concomitant use cannot be avoided, initiate repaglinide at 0.5 mg before each meal and do not exceed a total daily dose of 4 mg. Increased frequency of glucose monitoring may be required during concomitant use.
The emergence of epigenetic therapies has identified pan-class deacetylase (DAC) inhibitors as effective therapeutic agents for the treatment of lymphoma. While pan-class DAC inhibitors have led to FDA indications, clinical activity has been limited to the T-cell derived malignancies. The mechanism of action remains largely unknown and off-target effects lead to side effects including fatigue, gastrointestinal disturbances, and cytopenias. Recently, the development of isoform selective DAC inhibitors have opened the opportunity to investigate their mechanism. It is now recognized that DAC inhibitors not only have epigenetic properties, but have direct effects on transcription factors (p53), oncogenes (Bcl6), and protein degradation pathways (aggresome). Proteolysis occurs primarily through the ubiquitin-proteosome pathway. In states where this pathway is physiologically overwhelmed or therapeutically inhibited, the aggresome sequesters proteins for degradation. DAC6 is a class IIb deacetylase that facilitates misfolded protein transport to the aggresome for proteosome-independent proteolysis. Inhibition of the aggresome activates the unfolded protein response (UPR) pathway, a cellular quality control mechanism with two primary functions: (1) to promote survival during cellular endoplasmic reticulum (ER) stress by chaperoning proteins back for re-folding and halting further transcription until homeostasis is restored and (2) to signal CCAAT/enhancer binding protein (C/EBP)-homologous protein (CHOP) mediated apoptosis when homeostasis cannot be reestablished\[9\]. While most cells depend on both branches of the UPR to coordinate protein folding, lymphocytes physiologically down-regulate the UPR-apoptosis pathway, specifically CHOP, to allow for generation of high affinity antibodies. In addition to initiating genetic abnormalities (translocations and point mutations) lymphomas inherit this biology, and thus gain a survival advantage.

It has been shown ACY-1215, an Histone Deacetylase 6 (HDAC6)-selective, orally active small-molecule enzyme inhibitor has had single agent activity in a panel of lymphoma cell lines and mouse models, and marked synergistic activity with several agents such as bortezomib, carfilzomib, and ibrutinib, unpublished data. ACY-1215 has been studied in vivo in models of multiple myeloma and lymphoma with marked activity both as a single agent and in combination with bortezomib. Therefore ACY-1215 will be investigated for treatment of lymphoma as a single agent leading to future studies evaluating its effects in combination with other targeted agents known to be active in lymphoma and synergistic with ACY-1215.
PURPOSE:A cosmetic having improved quality and good feeling in use, containing one or both of dory oil and a hydrogenated material thereof. CONSTITUTION:A cosmetic containing one or both of dory oil extract and a  hydrogenated material thereof from oleo dory (scientific name, pseudocyttus  maculatus, Neocyttus rhomboidalis, Allocyttus sp.), a fish belonging to the family  Zeidae, living mainly in the sea of New Zealand, Australia, South Africa, etc.  with a depth of 600-1,000m. The dory oil is an oil having a refreshing touch  free from greasy feeling, and has good feeling in application to the skin. The oil  is an oil comprising an ester consisting of a straight-chain unsaturated fatty  acid and an unsaturated alcohol as a main component.
The invention provides a herbal tea beverage suitable for people with low blood pressure. The herbal tea beverage is prepared from, by weight, 12-25 parts of radix pseudostellariae, 10-20 parts of Radix Astragali preparata, 5-10 parts of cimicifugae foetidae, 6-12 parts of ophiopogonis radix, 12-22 parts of dioscorea opposita, 15-25 parts of semen sesami nigrum and 6-12 parts of green tea. The invention also provides a preparing method of the herbal tea beverage suitable for people with low blood pressure. The herbal tea beverage is ingenious in collocation and reasonable in component, and people are provided with low blood pressure with the herbal tea beverage which has the effects of tonifying qi and lifting yang, benefiting qi and nourishing yin, tonifying spleen, lung and kidney, promoting production of body fluid and nourishing the lung, replenishing qi and nourishing blood as well as tonifying and invigorating the human body. According to the herbal tea beverage, green tea and Chinese herbal medicine are adopted as the basic materials, and pure natural plants are carefully choosen to be used as the raw materials. Besides, the herbal tea beverage belongs to beverage of homology of medicine and food, is scientific in formulation and is produced through modern biotechnology processing; meanwhile, the herbal tea beverage is significant in effects and convenient to use, and has no side effects after long-term use.
In Group 1; The surgical procedure began with the adaptation of a prefabricated guide to the surgical site, ensuring firm stabilization. Implant positions were marked, and after the removal of the guide, a crestal incision was made. A mucoperiosteal flap was reflected, exposing the maxillary sinus and alveolar crest. The guide was readapted, marking implant positions, and a lateral window was formed using a bur or piezotome. Sinus membrane elevation was performed carefully. Implants were placed with graft material beneath the elevated membrane. In cases of bony plate preservation, the window was covered. In Group 2 (Lateral Maxillary Sinus Floor Elevation without a surgical guide), a crestal incision and mucoperiosteal flap exposed the sinus. A bony window was created, and careful elevation of the sinus floor followed. Implant osteotomies were completed, and graft material was packed into the sinus. A resorbable membrane was applied, and the flap was sutured. NanoboneÒ was used as the standard graft material in both groups.
Initiate a patient whose blood pressure is not adequately controlled with telmisartan monotherapy 80 mg on telmisartan and hydrochlorothiazide tablets, 80 mg/12.5 mg orally once daily. Dose can be titrated up to 160 mg/25 mg after 2 to 4 weeks, if necessary. 

Initiate a patient whose blood pressure is not adequately controlled by 25 mg once daily of hydrochlorothiazide, or is controlled but who experiences hypokalemia with this regimen on telmisartan and hydrochlorothiazide tablets 80 mg/12.5 mg once daily. Dose can be titrated up to 160 mg/25 mg after 2 to 4 weeks, if necessary. 

Patients titrated to the individual components (telmisartan and hydrochlorothiazide) may instead receive the corresponding dose of telmisartan and hydrochlorothiazide tablets. 

Telmisartan and hydrochlorothiazide tablets may be administered with other antihypertensive drugs.
<P>PROBLEM TO BE SOLVED: To provide a whole body administration type tape preparation (plaster) dosage form which is adhered to skin to absorb a medicine, whose dose can accurately be determined, and which can thereby simply be adjusted to a proper dose by anyone.  <P>SOLUTION: Graduation lines showing areas proportional to the doses of a medicine are printed on the back side (not coated with the medicine) of the tape preparation or on a protection sheet for covering the adhesive side of the tape. Perforated lines capable of being simply torn are also the same solution means in dependence on the material of the tape. Thereby, a user (patient) of the tape preparation can cut the tape preparation along the printed graduation line and use the tape preparation in an accurate dose without anxiety, when the fine adjustment of the medicine is needed. When the tape preparation is torn along the perforated line of the tape to adjust the dose of the medicine preparation, the tape preparation can similarly be used.  <P>COPYRIGHT: (C)2004,JPO
Priming enables plants to respond more promptly, minimise damage, and survive subsequent stress events. Here, we aimed to assess the efficacy of priming and cross-priming in mitigating the stress caused by waterlogging and/or dehydration in soybeans (Glycine max ). Soybean plants were cultivated in a greenhouse in plastic pots in which soil moisture was maintained at pot capacity through irrigation. The first stress was applied in plants at the vegetative stage for 5days and involved either dehydration or waterlogging, depending on the treatment. Subsequently, the plants were irrigated or drained and maintained at pot capacity until the second stress. For the second stress, the conditions were repeated in plants at the reproductive stage. We then evaluated the levels of hydrogen peroxide (H2 O2 ), lipid peroxidation, total soluble sugars (TSS), amino acids, proline, and starch, and the activity of antioxidant, fermentative, and aminotransferase enzymes. Under waterlogging and dehydration, priming and cross-priming significantly increased the activity of antioxidant enzymes and the levels of TSS, amino acids, and proline while reducing H2 O2 concentration and lipid peroxidation. Under waterlogging, priming suppressed fermentative activity and increased carbohydrate content. This demonstrates that soybean plants activate their defence systems more promptly when subjected to priming.
An oral serum made from natural ingredients that advantageously reduces oral bacteria. The oral serum is the starting material for several products, an oral rinse product, a gel product, and a toothpaste product. Additionally, a method for reducing oral bacteria, a method of removing debris from the oral cavity, and a method of reducing dry mouth is provided. Finally, a method for improved oral wound healing is provided. The oral serum of the present invention generally comprises a glycerin source, a liquid, an oxidizing agent, a nut extract or oil, aloe vera, cereal grass, a binder and a mentha component. The oral serum additionally comprises a preservative.
Electrode positioning will be determined according to the EEG 10-20 international system for EEG electrode placement: Affected hemisphere anodal stimulation of the hand area of the primary motor cortex (C3/C4), Intensity of 2 mA (milliampere) for duration of 20 minutes. A total of 10 sessions: 5 sessions a week for 2 weeks.
Thiolated polyethylenimine (PEI) polymers can be covalently attached to lipid shell microbubbles. The PEI polymer can be modified with polyethylene glycol (PEG) chains to improve biocompatibility. The covalent attachment of the PEI polymer to the microbubble shell can result from a bond between a free sulfhydryl group (SH) of the thiolated PEI and a free maleimide group on the microbubble shell. DNA can be electrostatically bound to the PEI polymers to form polyplexes. A plurality of the polyplex -microbubble hybrids can be injected into a patient and can be imaged via ultrasound. While circulating in the bloodstream, and in particular, within a region of interest, high-pressure, low-frequency acoustic energy can be applied, thereby causing destruction by cavitation. Such cavitation can transiently increase the permeability of the endothelial vasculature thereby allowing plasmid DNA of the polyplexes carried by the microbubbles to be delivered to targeted cells.