anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a plaster improved in transdermal adsorption effect of indomethacin by formulating paste in which indomethacin is compounded with tocopherol acetate, menthol and butylene glycol. SOLUTION: This plaster is obtained by formulating (A) 0.1-5wt.% indomethacin which is a nonsteroidal antiphlogistic sedative agent with (B) tocopherol acetate in an amount of 0.02-30 pts.wt. based on 1 pt.wt. component A, (C) method in an amount of 0.002-50 pt.wt. based on 1 pt.wt. components A, (D) 1,3-butylene glycol in an amount of 0.02-100 pts.wt. based on 1 pt.wt. component A and (E) as necessary, base components such as a water-soluble polymer, a stabilizer, a filler, a surfactant, an antiseptic agent, a crosslinking agent, a solubilizing auxiliary, a transdermal adsorption promoter and water to provide paste and spreading the resultant paste onto a support (e.g. nonwoven fabric), liner, etc.
Chronic alcohol use leads to metabolic dysfunction in adipose tissue. The underlying mechanisms and the contribution of alcohol-induced adipose tissue dysfunction to systemic metabolic dysregulation are not well understood. In our previous studies, we found that chronic alcohol feeding induces mesenteric lymphatic leakage, perilymphatic adipose tissue (PLAT) inflammation, and local insulin resistance in rats. The goal of this study was to further explore the link between alcohol-induced lymphatic leakage and PLAT immunometabolic dysregulation, locally and systemically, using in vivo and ex vivo approaches. Male rats received a Lieber-DeCarli liquid diet, of which 36% of the calories were from alcohol, for 10 weeks. Time-matched control animals were pair-fed. Adipokine levels were measured in PLAT, subcutaneous fat, plasma, and mesenteric lymph samples. Glucose tolerance was assessed after 10 weeks. Further, we used a novel ex vivo lymph-stimulated naïve PLAT explant approach to modeling lymph leakage to assess changes in adipokine secretion and expression of proinflammatory markers after stimulation with lymph from alcohol- or pair-fed animals. Our data show that chronic alcohol-fed rats presented PLAT-specific decreases in adiponectin and leptin levels, alterations in the expression of genes involved in lipid metabolic pathways, and associated impaired whole-body glucose homeostasis. Further, we found that direct naïve PLAT stimulation with lymph contents from alcohol-fed animals increased IL-6 expression in demonstrating the ability of lymph contents to differentially impact naïve adipose tissue. Overall, chronic alcohol feeding leads to depot-specific alterations in metabolic profile, impaired systemic glucose tolerance, and lymph-induced adipose tissue inflammation. The specific lymph components leading to PLAT immunometabolic dysregulation remain to be determined.
PURPOSE: A recombinant protein which suppresses virus is provided to strongly secrete interferon in case of presence of NS3/4a protein by viral infection and to reduce side effects. CONSTITUTION: A recombinant protein which suppresses virus comprises a transcription module, trigger module and safety module. The transcription module has a DNA binding domain(DBD) derived from IRF7 protein and a regulatory domain(RD). DBD comprises 2-151th amino acids of IRF7 protein. RD comprises 468-503th amino acids of IRF7 protein. A vaccine composition for preventing or treating viral diseases contains the recombinant protein as an active ingredient.
Keratoconus (KC) is a progressive, non-inflammatory corneal degenerative disease. It is a pathology characterized by a progressive thinning and protrusion of the cornea that ends in a cone-shaped cornea. This results in progressive myopia and irregular astigmatism with associated progressive loss of vision and thus reduced quality of life.Collagen cross-linking (CXL) is a relatively new conservative approach for progressive corneal ectasia. The main indication for CXL is to slow the progression of corneal ectatic diseases, such as keratoconus, pellucid marginal degeneration (PMD), keratoglobus and iatrogenic ectasia.The basic principle of this method is the chemical interaction of ultraviolet A radiation (315-400nm ) and riboflavin to induce covalent bond formation between collagen fibers of the cornea. In this way, the stiffness and rigidity of the cornea are provided.Corneal collagen cross-linking (CXL) was first introduced by Wollensak with an ultraviolet-A (UVA) protocol of 3 medium wave mW/cm2 intensity at 370 nm over an exposure time of 30 minutes (now termed the "Dresden protocol"). Researchers have proposed accelerated CXL (ACXL) protocols, to improve convenience and comfort for patients. These ACXL protocols have the aim of decreasing UVA exposure time by increasing UVA fluency to achieve the same overall total UVA dosage.Despite corneal CXL is a safe and effective procedure with few known side effects .Persistent corneal edema and possible endothelial cell damage have been reported in a few cases after CXL. Based on the extent of endothelial damage, patients may require penetrating keratoplasty.
BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) is a viral disease with worldwide distribution and an enormous economic impact. To control PRRS virus (PRRSV) infection, modified live vaccines (MLVs) are widely used in the field, mainly administered via an intramuscular (IM) route. Currently, some MLVs are authorized for intradermal (ID) administration, which has many practical and welfare advantages. The objectives of the study were to compare the immune responses (systemic in blood and mucosal in lungs) and vaccine efficacy in preventing challenge strain transmission after IM or needle-free ID immunization of piglets with an MLV against PRRSV-1 (MLV1).
METHODS: Groups of sixteen 5-week-old specific pathogen-free piglets were vaccinated with Porcilis PRRS® (MSD) either by an IM (V+ IM) or ID route (V+ ID) using an IDAL®3G device or kept unvaccinated (V-). Four weeks after vaccination, in each group, 8 out of the 16 piglets were challenged intranasally with a PRRSV-1 field strain, and one day later, the inoculated pigs were mingled by direct contact with the remaining 8 sentinel noninoculated pigs to evaluate PRRSV transmission. Thus, after the challenge, each group (V+ IM, V+ ID or V-) included 8 inoculated and 8 contact piglets. During the postvaccination and postchallenge phases, PRRSV replication (RT-PCR), PRRSV-specific antibodies (ELISA IgG and IgA, virus neutralization tests) and cell-mediated immunity (ELISPOT Interferon gamma) were monitored in blood and bronchoalveolar lavages (BALs).
RESULTS: Postvaccination, vaccine viremia was lower in V+ ID pigs than in V+ IM pigs, whereas the cell-mediated immune response was detected earlier in the V+ ID group at 2 weeks postvaccination. In the BAL fluid, a very low mucosal immune response (humoral and cellular) was detected. Postchallenge, the vaccine efficacy was similar in inoculated animals with partial control of PRRSV viremia in V+ ID and V+ IM animals. In vaccinated sentinel pigs, vaccination drastically reduced PRRSV transmission with similar estimated transmission rates and latency durations for the V+ IM and V+ ID groups.
CONCLUSIONS: Our results show that the tested MLV1 induced a faster cell-mediated immune response after ID immunization two weeks after vaccination but was equally efficacious after IM or ID immunization towards a challenge four weeks later. Considering the practical and welfare benefits of ID vaccination, these data further support the use of this route for PRRS MLVs.
PURPOSE:To provide the titled substance having excellent compatibility to surfactants of various compounded cosmetic compositions and resistant to deterioration with microbial action, etherifying a cellulose in a homogeneous reaction system in a state dissolved in a solvent and using the resultant water-soluble cellulose ether as a components. CONSTITUTION:The objective raw material substance for cosmetic is composed of a water-soluble cellulose ether (e.g. methylcellulose and hydroxypropyl methylcellulose) produced by etherifying a cellulose or a cellulose derivative (e.g. cellulose acetate) in homogeneous reaction system in a state dissolved in a solvent. The water-soluble cellulose ether can be produced e.g. by simultaneous saponification and etherification of cellulose acetate with an alkaline substance in a homogeneous reaction system dissolved in a solvent or by the etherifying and then deacetylating cellulose acetate. Cosmetics (such as milky lotion, lipstick and cream) compounded with said raw material substance has excellent spreadability, is free from stickiness and imparts moistness to finished skin.
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) is one of the most prevalent and distressing side effects of chemotherapy among patients with cancer worldwide. Despite continuing advances in antiemetic medicines, nausea and vomiting associated with cancer chemotherapy remain a substantial therapeutic concern for many patients. However, P6 and Auricular acupressure (AA) have been recognized as potential therapy for managing chemotherapy-induced nausea and vomiting.
AIM: This study aimed to evaluate the effectiveness of P6 and Auricular acupressure (AA) in reducing chemotherapy-induced nausea and vomiting among patients with cancer. And to explore a prominent and effective evidence-based protocol for implementing acupressure to treat chemotherapy-induced nausea and vomiting.
METHOD: This systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Several databases were used to search for eligible studies using specific keywords. Only systematic reviews and clinical trials on acupressure for managing CINV among adults with cancer were included. This review covered articles published in English from 2015 to 2022.
RESULTS: A total of 14 published studies were included in this review study; 10 articles were trial studies, and the other 4 were systematic review and meta-analysis studies. The quality of 10 included clinical trials were assessed using the Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for quantitative studies, the overall result showed that 40% of study rated with moderate quality, no study was rated with low quality, and (60%) studies rated as high-quality study. As well as the quality assessment of all review studies showed that the majority of included systematic reviews and meta-analysis with a low risk of bias and high to moderate power of evidence. In all included studies the acupressure was utilized as a primary complementary intervention for chemotherapy induced nausea and vomiting. The result of this extensive and comprehensive review the P6 and auricular acupressure is an effective complementary therapy in reducing and controlling chemotherapy-induced nausea and vomiting among participants with various types of cancer and receiving various types of chemotherapy.
CONCLUSION: The successful and effective application of acupressure in managing CINV for certain types of cancer had been supported in previous literature as a safe, affordable, and non-invasive alternative to pharmaceutical medications. However, standardization guidelines regarding the use of acupressure independently or in combination with other pharmacological therapies to address CINV in various cancers require immediate attention.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to dentistry, and can be used for surgical management of chronic generalized periodontitis of severe degree. Method involves a preoperative local anti-inflammatory therapy, Cieszynski-Widmann-Neumann's flap surgery, wound washing after removal of granulation and de-epithelialization of flaps, replacement of bone defects with osteoplastic material and suturing in interdental spaces. Preoperative anti-inflammatory therapy is performed for 14 days. In the first two days, the alveolar process of both jaws is coated both from the vestibular and oral surfaces, wadding-gauze beads impregnated with a solution of a two-component probiotic containing Bacillus Subtilis 11B and Bacillus licheniformis 31 strains in amount of 1 to 5 billion cells, in 10 ml of normal saline with exposure of 30 minutes. On the following days, gauze turrets soaked with a two-component probiotic solution are introduced, which are introduced into periodontal pockets for 30 minutes. Wound is washed with a similar solution of a two-component probiotic. Bone defects between the dental roots are replaced with a wound healing plate containing, wt%: biomass of the B. subtilis 3H 30–50 strain, collagen 50–70, which is preliminarily cut in the form of a rectangular truncated pyramid corresponding to the size and shape of the bone defect, wherein when replacing the bone cavity, the small base of the pyramid should be at the level of the dental neck, and the large base adjoins the lower wall of the bone cavity. Layer of the wound-healing plate is applied above the alveolar part of the jaw so that it is adapted to the outlines of the alveolar crest and the neck of the teeth. Flaps are mobilized in the direction of the dental neck and sutures are applied.EFFECT: method provides stimulating reparative osteogenesis and preventing inflammatory postoperative complications.1 cl, 2 ex
Dorzolamide 20mg/Timolol 5mg/Brimonidine 2mg combination drug. Participants will be administered 1 drop of TFC-003 ophthalmic solution twice a day for 4 weeks.
PURPOSE: To obtain a polymer mixture, comprising a polyionic polypeptide, a high-molecular weight polyanion and a highly charged polyanion and capable of providing a pH-dependent phase change in an aqueous solution and imparting the improved dispersibility and increased smoothness and uniformity to a cosmetic preparation. CONSTITUTION: This aqueous composition comprises water and a ternary polymer mixture of (A) a polyionic polypeptide, e.g. a protein, especially a blood serum albumin, (B) a high-molecular weight polyanion having about >=100,000, preferably about 1,000,000 to about 10,000,000 molecular weight, e.g. a polynucleotide or a polycarboxylate, especially hyaluronan or its derivative and (C) a highly charged polyanion having about <3pKa, especially about <1.5pKa in an amount so as to provide about <1,000, especially about 100 to about 350 equiv. weight of acidic groups, e.g. a polysulfate or a polysulfonate, especially dextran sulfate. The aqueous composition is capable of providing a pH-depefident phase change in an aqueous solution (e.g. a change in light transmittance).  The preferred amount of the respective formulated components are about 0.1 to about 20wt.% of the component A and about 0.05 to about 1wt.% each of the components B and C.
PROBLEM TO BE SOLVED: To meet the demand for a gel devoid of viscoelasticity such as a brain model material, etc. used for surgery and cannulation practices and to provide a gelled composition having eliminated shortcomings of conventional gelled polyalcohol compositions prone to separation at a high temperature and deficient in terms of long-term stability.SOLUTION: It was discovered that, if a glycyrrhizinic acid diester expressed by the formula (1) is dissolved into glycerin at an appropriate ratio and then left unattended over a specified period, the glycerin solution of the glycyrrhizinic acid diester is gelled. This gel has, unlike gelatin or agar, an attribute of the absence of temperature sensitivity. In other words, it is not re-liquefied even under high-temperature conditions. The present gel, furthermore, is devoid of viscoelasticity and therefore has potential attributes as a brain model material for which food jellies, etc. are being currently used for the lack of alternatives. It also has a long-term stability and is usable as a polyalcohol gel usable in fields of cosmetics, etc.
Critically ill COVID-19 patients with ARDS requiring ECMO support will be analyzed in this group. Patients from all three study sites will be assessed for participation.
A novel and effective strategy for organ transplantation is provided. A therapeutic agent and method for preventing an acute rejection in a transplanted organ and improving prognosis are provided. A therapeutic agent for suppressing a rejection in organ transplantation, which comprises an NF- kappa B decoy compound, is provided. Representatively, the organ transplantation is kidney transplantation. The therapeutic agent further comprises an ultrasonic inspection contrast agent. A therapeutic agent for improving prognosis in organ transplantation is also provided. The therapeutic agent is administered into a donor organ. The transfection efficiency of the NF- kappa B decoy compound into the organ may be enhanced by ultrasound treatment.
A randomized controlled trial (RCT) was conducted. The participants recruited from aboriginal communities in Eastern Taiwan. Data collecting time was from 2019 to 2020. Participants from the identified communities were randomly assigned to EG or CG using random table. Participants who were 55 years old or above and indigenous people were recruited in the study. Participants who were disability, have had oral cancer, impaired facial appearance and impaired cognitive function were excluded. Impaired cognitive function was screening by Short Portable Mental Status Questionnaire (SPMSQ). Participants were recruited according to the predetermined minimal sample size estimated based on a type I error = 0.05, power = 0.95, and effect size (ES) f = 0.25 (medium effect in Cohen's f) . The number of samples in each group was expected 66 participants. An additional 30% drop out rate was added. The final number of samples for each group were required at least 86 participants. The total sample size was 122 and 118 in EG and CG, respectively. All participants underwent data collection at baseline and at 2-week, 3-and 6-month follow-ups.
BACKGROUND: The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal motor nucleus of the vagus (DMN), as recently shown using optogenetics. In contrast to optogenetics, electrical neuromodulation has broad therapeutic implications. However, the anti-inflammatory effectiveness of electrical stimulation of the DMN (eDMNS) and the possible heart rate (HR) alterations associated with this approach have not been investigated. Here, we examined the effects of eDMNS on HR and cytokine levels in mice administered with lipopolysaccharide (LPS, endotoxin) and in mice subjected to cecal ligation and puncture (CLP) sepsis.
METHODS: Anesthetized male 8-10-week-old C57BL/6 mice on a stereotaxic frame were subjected to eDMNS using a concentric bipolar electrode inserted into the left or right DMN or sham stimulation. eDMNS (500, 250 or 50 μA at 30 Hz, for 1 min) was performed and HR recorded. In endotoxemia experiments, sham or eDMNS utilizing 250 μA or 50 μA was performed for 5 mins and was followed by LPS (0.5 mg/kg) i.p. administration. eDMNS was also applied in mice with cervical unilateral vagotomy or sham operation. In CLP experiments sham or left eDMNS was performed immediately post CLP. Cytokines and corticosterone were analyzed 90 mins after LPS administration or 24 h after CLP. CLP survival was monitored for 14 days.
RESULTS: Either left or right eDMNS at 500 μA and 250 μA decreased HR, compared with baseline pre-stimulation. This effect was not observed at 50 μA. Left side eDMNS at 50 μA, compared with sham stimulation, significantly decreased serum and splenic levels of the pro-inflammatory cytokine TNF and increased serum levels of the anti-inflammatory cytokine IL-10 during endotoxemia. The anti-inflammatory effect of eDMNS was abrogated in mice with unilateral vagotomy and was not associated with serum corticosterone alterations. Right side eDMNS in endotoxemic mice suppressed serum TNF and increased serum IL-10 levels but had no effects on splenic cytokines. In mice with CLP, left side eDMNS suppressed serum IL-6, as well as splenic IL-6 and increased splenic IL-10 and significantly improved the survival rate of CLP mice.
CONCLUSIONS: For the first time we show that a regimen of eDMNS which does not cause bradycardia alleviates LPS-induced inflammation. These eDMNS anti-inflammatory effects require an intact vagus nerve and are not associated with corticosteroid alterations. eDMNS also decreases inflammation and improves survival in a model of polymicrobial sepsis. These findings are of interest for further studies exploring bioelectronic anti-inflammatory approaches targeting the brainstem DMN.
As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken.

The dose of ceftibuten may require adjustment in patients with varying degrees of renal insufficiency, particularly in patients with creatinine clearance less than 50 mL/min or undergoing hemodialysis (see DOSAGE AND ADMINISTRATION). Ceftibuten is readily dialyzable. Dialysis patients should be monitored carefully, and administration of ceftibuten should occur immediately following dialysis.

Ceftibuten should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.
Transcranial direct current stimulation (tDCS) is one of the non-invasive brain stimulation (NIBS) techniques. It delivers weak direct current through the scalp via two electrodes. tDCS has been shown to modulate cortical excitability in polarity-specific effects; anodal increases cortical excitability, while cathodal decreases it. tDCS can be applied in two distinct montages: unilateral (an active electrode is applied over the cerebral cortex, while a reference electrode is applied over the contralateral orbit) and bilateral-tDCS (applying two electrodes simultaneously over both cerebral hemispheres). Many tDCS studies have been used as an add-on therapy in stroke patients which aimed to enhance motor re-learning after stroke. Anodal tDCS has been used to enhance cortical excitability in the lesioned hemisphere while cathodal tDCS is used to decrease it in the non-lesioned hemisphere and thus to rebalance the interhemispheric inhibition (IHI). However, there were recent studies reporting the reverse effect of cathodal-tDCS on cortical excitability at high doses. However, the effects of cathodal-tDCS among different doses on cortical excitability and on motor performance are still controversial no report of a non-linear effect for bilateral-tDCS.

The present study will be investigated the effects of different intensities of unilateral cathodal tDCS and bilateral tDCS on cortical activity and functional outcomes in healthy individuals. A single session of different intensities of bilateral-tDCS or cathodal-tDCS (i.e., 1 mA, 1.5 mA, 2 mA vs. sham) will be combined with serial reaction time task (SRTT) in healthy individuals. Cortical activity will be measured as a primary outcome. All power bands (alpha, beta, delta, theta) will be analyzed. Moreover, analysis of brain activity will be also focused on both hemispheres. The reaction time of serial reaction time task and muscle strength will be served as the secondary outcome. Cortical activity and muscle strength will be evaluated before and after the intervention, while reaction time will be evaluated during and after the intervention.