anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Ischemic stroke is followed by an increased susceptibility to bacterial infections, which exacerbate histological stroke outcome, neurological deficits and memory impairment due to increased neuroinflammation and neurotransmitter dysfunction. Pharmacological activation of nicotinic acetylcholine receptors was suggested to mitigate brain inflammatory responses in ischemic stroke. The functional responses associated with nicotinic acetylcholine receptor activation were unknown. In this study, male NMRI mice subjected to transient intraluminal middle cerebral artery occlusion (MCAO) were intraperitoneally exposed to vehicle treatment or Escherichia coli lipopolysaccharide (LPS; 4 mg/kg)-induced sepsis-like state 24 h post-MCAO, followed by intraperitoneal administration of vehicle or nicotine (0.5 mg/kg) 30 min later. Over 96 h, rectal temperature, neurological deficits, spontaneous locomotor activity, working memory, ischemic injury, synaptic plasticity, and brain inflammatory responses were evaluated by temperature measurement, behavioral analysis, infarct volumetry, electrophysiological recordings, and polymerase-chain reaction analysis. LPS-induced sepsis induced hypothermia, increased general and focal neurological deficits, reduced spontaneous exploration behavior, reduced working memory, and increased infarct volume post-MCAO. Additional treatment with nicotine attenuated LPS-induced hypothermia, reduced neurological deficits, restored exploration behavior, restored working memory, and reduced infarct volume. Local field potential recordings revealed that LPS-induced sepsis decreased long-term potentiation (LTP) in the dentate gyrus post-MCAO, whereas concomitant nicotine exposure restored LTP in the contralateral dentate gyrus. LPS-induced sepsis increased microglial/ macrophage Iba-1 mRNA and astrocytic GFAP mRNA levels post-MCAO, whereas add-on nicotine treatment reduced astrocytic GFAP mRNA. Taken together, these findings indicate that acute nicotine exposure enhances functional stroke recovery. Future studies will have to evaluate the effects of (1) chronic nicotine exposure, a clinically relevant vascular risk factor, and (2) the cessation of nicotine exposure, which is widely recommended post-stroke, but might have detrimental effects in the early stroke recovery phase.
The present invention relates to compositions comprising stimuli- responsive materials which can be used for delivery of agents. Materials are provided that can respond to changes in a surrounding environment, including changes in ion concentration. For example, one or more properties of the material may be affected by a change in pH and/or a change in the concentration of an ion. Such properties may include, for example, a dimension of the material (e.g., volume), the permeability of the material, and the like. In cases where the material comprises a therapeutic or diagnostic agent, the material may undergo a change in the rate of release of the agent upon exposure to certain conditions. The invention may also provide the use of said compositions for the manufacture of a medicament for delivering a therapeutic or diagnostic agent, in some cases, with enhanced selectivity and sensitivity.
BACKGROUND: Observational studies have linked low vitamin D (VD) levels to increased asthma attacks in children. Subsequent meta-analyses of adults and children revealed that VD treatment might benefit asthmatic patients by reducing the incidence of exacerbations. Therefore, this review aims to analyze the effects of VD supplementation in reducing asthma exacerbations in children.
METHODS: Published reports from PubMed, Cochrane, and Google Scholar were systematically searched until April 2023. The study protocol was registered in the PROSPERO database CRD42023411796. Randomized controlled trial studies were included in this review. Meta-analysis was performed using Cochrane RevMan 5.1 and presented with 95% confidence intervals (CIs).
RESULTS: Ten relevant studies enrolled 1243 asthmatic children (631 children receiving vitamin D3 supplementation, 612 children receiving placebo) were included in this review. Our pooled analysis found that VD supplementation had a significant effect on lowering the total number of asthma exacerbations (RR 0.62; 95% CI: 0.44, 0.87; p = 0.01). Subgroup analysis revealed that a daily dose of VD given based on standard daily dose recommendation had a significant improvement on asthma exacerbations [(RR 0.41; 95% CI: 0,18, 0,92; p = 0.03).
CONCLUSIONS: Vitamin D supplementation can lower the occurrence of exacerbations in children with asthma, along with the improvement of FEV1.
The present invention relates to miRNA interference technology. More specifically the invention relates to circular miRNA sponges that carry a plurality of binding sites directed to at least two types of miRNA and separated by random, non-identical spacers, allowing for the inhibition of functional classes of mlRNAs. Preferably, the binding sites are bulged binding sites wherein each bulge is created by a one base deletion and two base mismatch at positions 9- 11 nt from the 3' end of each binding site. Preferably, each spacer is 6 to 24 nucleotides in length. Preferably, the binding sites are against miR-132 and miR-212, miR-17-5p and miR-18a-5p, or miR-20b-5p and miR-106a-5p. Construction vectors and uses of said miRNA sponges for the treatment of diseases, such as cardiomyopathy and cancer, are also disclosed.
INTRODUCTION: Intravenous immunoglobulin (IVIG) plus methylprednisolone as initial intensive therapy or additional therapy in Kawasaki disease (KD) has been used in clinical practice. However, its molecular and cellular mechanism is unclear.
METHODS: We performed single-cell analysis on 14 peripheral blood mononuclear cell (PBMC) samples obtained from 7 KD patients who received either IVIG monotherapy or IVIG plus methylprednisolone therapy. This encompassed 4 samples from KD patients collected before and after IVIG treatment, as well as 3 samples from KD patients before and after IVIG plus methylprednisolone therapy.
RESULTS: Both IVIG monotherapy and IVIG plus methylprednisolone therapy can increase lymphocyte counts (e.g. CD4+T, CD8+T, and gdT cells) to address lymphopenia. They can also decrease monocyte counts and repress the expression of S100A12, NLRP3, and genes associated with immune-cell migration in monocytes. IVIG combined with methylprednisolone downregulates more monocyte-driven inflammatory pathways than IVIG alone. Additionally, this combination uniquely enhances NK cell cytotoxicity by modulating receptor homeostasis, while significantly upregulating interferon-related genes in CD4+ T cells, CD8+ T cells, and B cells, particularly type I interferons.
CONCLUSION: The combination of IVIG with methylprednisolone attenuated monocyte-driven inflammation and improved NK cell cytotoxicity which might provide clues for pediatricians to consider treatment options for children with KD. Whether the monocyte-driven hyperinflammatory state and NK cell function can be indicators for the clinical choice of IVIG with methylprednisolone therapy in KD needs further investigation.
Frontotemporal dementia (FTD) with its multiple pathological manifestations, is a disease that results in progressive deterioration of social comportment, executive function, and language. Despite the debilitating nature of FTD and the relatively high prevalence in the younger patient population, available pharmacological interventions are limited to symptomatic treatments. There are no therapeutic agents that have been developed that specifically treat the progressive cognitive symptoms of FTD. This project will study IN insulin in FTD in 12 patients. Investigators aim to evaluate the feasibility of the EXAMINER cognitive battery as a cognitive outcome measure in FTD, the ability of the HealthPartners Center for Memory and Aging's Center's ability to sufficiently recruit subjects with FTD, and the safety of IN regular insulin administered 20 IU twice per day in two specific variants of FTD (behavioral variant frontotemporal dementia (bv-FTD), semantic dementia (SD)) over a 4 week period. Frontotemporal dementia (FTD) with its multiple pathological manifestations, is a disease that results in progressive deterioration of social comportment, executive function, and language. Despite the debilitating nature of FTD and the relatively high prevalence in the younger patient population, available pharmacological interventions are limited to symptomatic treatments. There are no therapeutic agents that have been developed that specifically treat the progressive cognitive symptoms of FTD.
Methods, systems, and devices for healthcare communications and more specifically to medical provider to medical provider communications are described. A medical provider may access patient information associated with a patient via an application on a device. The medical provider may select, via the application, a remote medical provider from a list of remote medical providers or a medical diagnosis for the patient, or both, based on the patient information. The device may establish, using a communication protocol, a multimedia session with a remote device associated with the remote medical provider. The medical provider or the remote medical provider, or both may determine whether to initiate a patient transfer procedure for the patient based on the multimedia session. As a result, the medical provider may via the device transmit, to the remote device, an indication of whether to initiate the patient transfer procedure for the patient.
The oculomotor abnormalities have been reported in some dyslexic children. The purpose of the study was to evaluate the effects of oculomotor rehabilitation on the reading performance of dyslexic children. Subjects were 50 dyslexic children. Those with oculomotor abnormalities (n = 30) were randomly assigned into 2 groups matched for age. The case group received oculomotor rehabilitation. The rehabilitation program consists of 3 different exercises. The reading and dyslexia tests were performed before and after the intervention. The correct scores of reading tests in the case group posttest increased significantly compared with the control group, and there is a significant difference between the two groups (P = .001). The positive effects of oculomotor rehabilitation on the reading performance of dyslexic children confirmed that the oculomotor program could be a practical tool for improving reading performance in dyslexic children.
An apparatus includes a chamber container and a tray. The chamber container has a first portion and a second portion removably coupled to the first portion. The first and second portions collectively define an inner volume. The tray is configured to be removably disposed within the inner volume of the chamber container. The tray includes a first portion and a second portion coupled to the first portion via a hinge. The first portion includes a first retention surface. The second portion includes a second retention surface. The tray is configured to receive a biodiffusion chamber between the first portion and the second portion such that the first retention surface and the second retention surface engage a portion of the biodiffusion chamber to (1) place the biodiffusion chamber in a predetermined orientation and (2) maintain the biodiffusion chamber in a substantially fixed position relative to the tray.
Group 1: Dental treatment was carried out with showing cartoon movie as a visual/auditory distraction during the treatment in the second visit. The third visit did not consist any visual/auditory distractions, tell-show-do technique was used as a behavioural guidance technique.
INTRODUCTION: Patients without concurrent baseline stress urinary incontinence (SUI) can develop de novo SUI after transvaginal mesh surgery (TVM) for cystocele repair. Surgeons should be aware of de novo SUI risk factors after TVM.
METHODS: A total of 1124 women who were underwent TVM surgeries were recruited and assessed for eligibility from January 1, 2012 to April 30, 2021. All data related to patients and surgeries was collected, which included general conditions, clinical examination, surgery records, and follow-up results. Patients were divided into three groups according to follow-up results and data were compared with each group. The relative risk (RR) of de novo SUI with levator avulsion was also calculated.
RESULTS: Three hundred thirty-six patients were included in this study. They were divided into no complication group (n = 249), de novo SUI group (n = 68), and other complications group (n = 19). It seemed elder or obese women had a higher risk of de novo SUI after TVM (p < 0.05). In de novo SUI group, incidence of levator avulsion before surgery were higher than the other two groups (p = 0.001). TVM can significantly change a prolapse to point Aa and Ba on POP-Q quantification system (p < 0.05). RR ratios of de novo SUI with unilateral avulsion group is 2.60 (95% confidence interval [CI] 1.39-4.87), and 2.58 (95%CI 0.82-8.15) for bilateral group.
CONCLUSION: Unilateral levator avulsion, instead of bilateral levator avulsion, is a risk factor of de novo SUI after cystocele repair surgery.
PURPOSE:To obtain a new type hair dye consisting essentially of an acid dye used in a semipermanent hair color, further a high-molecular weight silicone, a dissolvent therefor and a polyoxyalkylene type surfactant without any problems. CONSTITUTION:This hair dye consists essentially of an acid dye used in a semipermanent hair color (e.g. an azo-based, a triphenylmethane-based or a nitro-based acid dye), further a high-molecular weight silicone compound (a compound having 100000-4000000 molecular weight and polysiloxane bond as a main chain), a dissolvent therefor (e.g. an isoparaffinic hydrocarbon or a low-molecular weight silicone compound) and a polyoxyalkylene type surfactant (e.g. a surfactant having a polyoxyalkylene chain in the molecule and >=4 HLB). The hair dye is improved in dyeability and excellent in touch after dyeing the hair and hardly falls off even by washing without any damage to the hair or contact dermatitis. The hair dyeing step is short and buildup properties are good. Furthermore, the resistance to shampoos or fastness to water is improved.
Sodium Chloride tested in an exercise state. Participants will have the placebo then exercise will be performed at 40% of maximal aerobic capacity for one hour.
The invention provides a biologic adhesion preparation of active carbon for bowels and its preparation method. The preparation comprises (by weight percentage) active carbon 30-90%, adjuvant with biologic adhesion function 10-70%, and other adjuvant in balance. Adjuvant with biologic adhesion function is hydroxypropyl methyl cellulose and/or chitosan and/or carbomer and/or polycarbophil and/or ethyl acrylate and/or carbopol. The preparation method comprises mixing active carbon with medicinal adjuvant including biologic adhesionagent, bulking agent and lubricant, preparing into core material, coating with one or multi-layer enteric coat or filling in enteric-coated capsules. The invention can be prepared into pill, tablet, granule, or capsule. Compared with common active carbon preparation, the preparation can be directly transmitted to duodenum and generate biologic adhesion with intestinal wall after oral administration, has intestinal location and sustained release, can improve therapeutic effect, reduce administeration dose and times. The inventive preparation is mainly used for treating chronic rnal failure, drug poisoning, and acute/chronic lead poisoning.
A method for diagnosing colic type in an infant exhibiting one or more symptoms characteristic of unspecified colic is disclosed. The method comprises the steps of: o optionally measuring at least one parameter indicative of unspecified colic; o orally administering a liquid formulation of a beta -D-galactosidase enzyme separately, simultaneously with or sequentially to a lactose-containing feed; o determining at selected intervals of time any alteration in the colic-type symptoms. An improvement in said symptoms of at least 50 % or greater is indicative of lactose-based intolerance. Where the enzyme formulation fails to alleviate the symptoms of unspecified colic, the infant is then placed on a diet of low allergen feed. An improvement in said symptoms of 50 % or more is indicative of allergen-based colic requiring maintenance on a low allergen-based diet. A failure to respond to such a low allergen-based diet is indicative of a need of further investigation, because the symptoms may be due to low-level infection or a metabolic error.
Pain assessment was performed on the child in the relevant group 4 hours after surgery, and then while playing an online game that the child knew, liked, and wanted to play, a clean gauze-wrapped cold gel pack was applied to the surgical site for cold therapy. The interventions lasted for 20 minutes.
PURPOSE:To provide a W/O-type cosmetic containing exclusively silicon carbide powder or the powder and an ether-modified silicone and a silicone oil, having durable ultraviolet-protection effect and high fittability to the skin and giving excellent finished skin and good feeling to the skin. CONSTITUTION:This W/O-type cosmetic contains silicon carbide powder having excellent ultraviolet protection effect, low surface activity and good stability of compounded components. The feeling to the skin is further improved by using the silicon carbide powder in combination with an ether-modified silicone and a silicone oil. The amount of the silicon carbide powder to be compounded to the cosmetic is preferably 1-25wt.%. Any organopolysiloxane may be used as the ether-modified silicone provided that at least a part of the organopolysiloxane has a substituent having ether bond. The amount of the ether-modified polysiloxane is preferably 1-10wt.%. The silicone oil is e.g. octamethylpolysiloxane, methylpolysiloxane, etc., and its amount is preferably 10-60wt.%.
Treatment comprises (A) a drink for internal consumption comprising (a) 40-85% diet juice e.g. of tomato, orange, carrot, cherry or grape, (b) 5-35% spray dried L-aminoacids derived from tissue protein, K, Ca, Mg, and fe and (c) 5-55% cold pressed juice of merismatic tissue of tropical green leaf plants such as cactus types and pampas grass, and (B) hair gel for external application comprising (a) 50-95% cold pressed juice of merismatic tissue of tropical green leaf plants such as cactus types and pampas grass treated with gelatinin (sic) stabilisers and (b) 5-30% cold pressed juice of merismatic tissue of green weed plants such as ribwort (plantago lanceolata), dandelion (Taraxacum officinale) or nettle, with addn. of 30-50% alcohol. USE/ADVANTAGE - The treatment is useful for treating conditions such as male pattern baldness and alopecia areata. The treatment gives immediate redn. in the rate of hair loss to the normal level of 40-120 hairs/day and promotes regrowth of hair in areas where hair loss has taken place.
Subjects in this arm will be asked to apply their assigned medication twice daily to their entire face. The medication they will be receiving is cromolyn sodium ophthalmic solution, 4%.
In the first interview, the mobile phone contact information of the elderly will be obtained and planning will be made for the first home visit when appropriate. Physical activity education and health promotion during home visit brochure will be provided. A brochure containing healthy lifestyle habits, health responsibility, exercise, nutrition, oral hygiene and social support behaviors will be provided for general health promotion awareness. The Google Fit application, which is a mobile application, will be downloaded to the phones of the people and installed together, how to use the application will be explained and the application will be made. The group walk to be done. A reminder message will be sent by phone. Message content "For your health, you should exercise at least 30 minutes a week for a total of 150 minutes." will be. Groups of five will be formed for the group walking, and it will be completed within seven days.
Colonoscopy is currently the main approach for detecting mucosal abnormalities in the whole colon. Inadequate bowel preparation is the predominant threaten to the efficacy of colonoscopy.Unfortunately, about 30% of patients were reported to suffer inadequate bowel preparation. In order to improve adequate bowel preparation rate, it is desirable to prescribe personalized regimen according to patient characteristics. We intend to improve adequate bowel preparation rate by deploying tailored bowel preparation strategy. There are many predictive factors of inadequate bowel preparation such as obesity, constipation, abdominal surgery and so on. By recognizing these risk factors of the patients , we can prescribe the patients with higher dose of bowel cleansing regimen to improve bowel preparation quality.
Polyomavirus BK virus (BKV) infection and nephropathy is a significant cause of allograft dysfunction in kidney transplantation. Clinical manifestation ranges from BK viremia and nephritis to renal dysfunction. It has been suggested that BK virus reactivation alone is not sufficient to cause BK viremia and nephropathy, thus a second hit is essential for kidney specific damage, such as an inflammatory reaction or ischemia. Critically ill postoperative/posttraumatic patients via the systemic inflammatory response syndrome (SIRS) and the compensatory antiinflammatory response syndrome (CARS) are at increased risk to develop organ dysfunctions, such as acute renal failure. CARS, reflecting postoperative/posttraumatic immunosuppression, may favor viral reactivation. However, prevalence of BK viremia in critically ill postoperative/posttraumatic patients has up to now not been systematically evaluated. Moreover, it is not known whether BK viremia is associated with a distinct biomarker pattern in these patients. Therefore, the present study is performed to clarify whether postoperative/posttraumatic immunosuppression is associated with BK viremia, and acute renal failure with BK virus reactivation, respectively.
Developmental language disorder (DLD) describes the idiopathic disorder(s) of language that occurs in approximately 7% of the population. Although DLD is understudied in adulthood, it is clear that the communication challenges in DLD extend beyond adolescence. The barriers to educational and vocational achievement for adults with DLD include persistent difficulties in learning and memory. Recent work suggests that these difficulties with learning and memory include deficits in overnight memory consolidation. Thus, an effective support for learning and memory function in adults with DLD must include strategies for both overcoming initial challenges in learning, as well as in mitigating a deficit in consolidation of learned information. In this project, the investigators combine insights from the neurobiology of learning and memory, chronobiology, and speech perception, to determine the optimal training schedule for perceptual memory retention in adults with and without DLD. The investigators have two Aims in this project: First, the investigators will recruit 240 adults (120 with/120 without DLD) to participate in a speech-perceptual training to take place in one of six different training schedules over 24 hours. The investigators predict that our manipulation of training schedules will interact with circadian preference and timing relative to overnight consolidation, to allow the discovery of the optimal practice schedule for speech sound retention for adult learners with \& without DLD. Under our second aim, the investigators will recruit an additional 300 adults (150 with/150 without DLD) in order to determine how optimal training schedules interact with reflexive and reflective learning strategies in adults with and without DLD. The investigators will achieve this aim by tracking the time course of learning and retention in adults participating in reflexive and reflective categorization training in one of six training schedules.