anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide antibodies or related molecules that immunospecifically bind to TRAIL receptor, TR4.  <P>SOLUTION: This invention provides TR4 polypeptide or fragments thereof, or an antibody that immunospecifically bind to a modified body (fragments thereof or molecules including the modified bodies or molecules composed therefrom). Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. This invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors, and host cells containing these nucleic acids, and a method for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating, or ameliorating a disease or disorder, especially cancer, and other hyperproliferative disorders.  <P>COPYRIGHT: (C)2009,JPO&INPIT
We will measure 2 indoor environments (living room and bedroom) for placing potted plants. We will analyze the effect of potted mint plants on indoor air quality, fungal and bacterial concentration, and explore the correlation between the intervention of potted mint plants and cardiovascular health.
<P>PROBLEM TO BE SOLVED: To provide a magnetic pasting sheet that is easy to paste on the body and has no concern about bad influences on the body by magnetism.  <P>SOLUTION: The magnetic pasting sheet 1 is constituted of a base material 5 comprised of a urethane nonwoven fabric which is formed belt-like and elastic, a pressure-sensitive adhesive layer 2 formed on one surface of the base material 5, and a release paper 12 attached on the pasting surface of the pressure-sensitive adhesive layer 2. The pressure-sensitive adhesive layer 2 includes an acrylic pressure-sensitive adhesive 7 and, incorporated therewith, a magnetic aluminum-manganese alloy powder 10 as a magnetic powder. The amount of the magnetic aluminum-manganese alloy powder 10 is 5-20 wt.% based on the pressure-sensitive adhesive 7. The magnetic flux density in the pressure-sensitive adhesive layer 2 is set to 0.3-1.0 mT by the magnetic aluminum-manganese alloy powder 10. Thus, efficient blood circulation is facilitated without permitting magnetism to act so excessively as to exert bad influences on the body.  <P>COPYRIGHT: (C)2010,JPO&INPIT
PROBLEM TO BE SOLVED: To obtain a melanin production inhibitor excellent in skin lightening action. SOLUTION: This melanin production inhibitor comprises a complex of an oligogalacturonic acid as a pectin of the formula (M is a transition metal ion; (n), (o) and (p) are each 0 or a natural number) or its hydrolyzate and a transition metal. The oligogalacturonic acid is obtained by hydrolyzing a pectin with an enzyme and separating by ultrafiltration, etc., and purified to have 1-10 degree of polymerization. The equivalent ratio of the oligogalacturonic acid to the transition metal used in the complex is 1:2 to 1:6. The objective skin lightening cosmetic can be prepared by using 0.01-10wt.% of the melanin production inhibitor. The melanin production inhibitor can suppress formed melanin and lighten skin.
Stroke remained the leading cause of disability in the world, and the most important non-modifiable risk factor was age. The treatment of stroke for elder patients faced multiple difficulties due to its complicated pathogenesis and mechanism. Therefore, we aimed to identify the potential differentially expressed genes (DEGs) and singnalling pathways for aged people of stroke. To compare the DEGs in the aged rats with or without middle cerebral artery occlusion (MCAO) and to analyse the important genes and the key signaling pathways involved in the development of cerebral ischaemia in aged rats. The Gene Expression Omnibus (GEO) analysis tool was used to analyse the DEGs in the GSE166162 dataset of aged MCAO rats compared with aged sham rats. Differential expression analysis was performed in aged MCAO rats and sham rats using limma. In addition, the 74 DEGs (such as Fam111a, Lcn2, Spp1, Lgals3 and Gpnmb were up-regulated; Egr2, Nr4a3, Arc, Klf4 and Nr4a1 were down-regulated) and potential compounds corresponding to the top 20 core genes in the Protein-Protein Interaction (PPI) network was constructed using the STRING database (version 12.0). Among these 30 compounds, resveratrol, cannabidiol, honokiol, fucoxanthin, oleandrin and tyrosol were significantly enriched. These DEGs were subjected to Gene Ontology (GO) function analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis to determine the most significantly enriched pathway in aged MCAO rats. Moreover, innate immune response, the complement and coagulation cascades signaling pathway, the IL-17 and other signaling pathways were significantly correlated with the aged MCAO rats. Our study indicates that multiple genes and pathological processes involved in the aged people of stroke. The immune response might be the key pathway in the intervention of cerebral infarction in aged people.
FIELD: medicine, immunology, pharmacology. SUBSTANCE: medicinal agent has low-molecular component prepared from protein-containing raw by extraction with organic solvents followed by substance drying and its dissolving in 60-90% alcohol, ionized selenium organic salt, organic carbohydrates and different molecular structures: calcium silicate, calcium iodide, calcium cyanide, calcium phosphate, strontium silicate, magnesium phosphate, ferrophosphate that are the ionized liquid solutions. Mixture of these substances is placed in electromagnetic sinusoidal high-frequency field and kept at 20-30 MHz for 5 min. One ml of complex of immunostimulating agent has 20-30 mg of the substance and 6 mcg of selenium in the mole ratio of carbohydrates to proteoselenium 1:5. Molar ratio of glycoproteo-selenium complex to inorganic ionized molecular structures is (1:2)-(1:8). Invention provides preparing the agent intaking of that results to systemic curative effect based on activation of receptors of cells of immune system and without adverse effects. EFFECT: enhanced effectiveness of agent. 17 cl, 10 ex
Aim: critical illness often leads to malnutrition and diaphragmatic dysfunction (DD), common in intensive care units (ICU). Ultrasonography (US) is a potent tool for detecting DD. This study examines the connection between malnutrition risk and DD in ICU patients using ultrasonographic diaphragm measurements in medical ICU patients. Methods: we assessed nutritional risk using risk screening tools and mid-upper arm circumference measurements (MUAC). Diaphragm atrophy (DA) and DD were evaluated by measuring diaphragmatic excursion (DE), thickness, and thickening fraction (TF) by US. We then compared these diaphragmatic measurements in patients based on their nutritional risk scores. Results: of the fifty patients studied, 54 % to 78 % were at risk of malnutrition, 28 % exhibited diaphragm atrophy (DA), and 24 % showed DD upon ICU admission. Malnutrition risk diagnosed by all nutritional risk screening tools was significantly more frequent in patients with DD, while diagnosed by MUAC was considerably higher in patients with DA. A total of 16 patients (32 %) died during their ICU stay, with DD, DA, and malnutrition risks (as identified by the mNUTRIC Score) being more prevalent among non-survivors (p < 0.05). Malnutrition risk (as determined by the mNUTRIC Score) was an independent risk factor for DD [OR (95 % CI): 6.6 (1.3-34), p = 0.03]. Conclusion: malnutrition risk may be significantly associated with DD and DA in medical ICU patients upon ICU admission.
The research study examines the feasibility, implementation, and efficacy of the interactive expert system intervention for smoking cessation in the Chinese American population. The primary specific aim of the proposed research is to test the following hypotheses: 1) Proactive recruitment approach will be more effective in recruiting smokers who are in precontemplation (no intent to quit smoking in the next 6 months) than a reactive approach. 2) Participants in the experimental condition receiving the interactive stage-matched expert system intervention plus a manual will be more likely to be abstinent at 12 and 18 than those in the control condition receiving a non-interactive standard manual. 3) Participants receiving the interactive expert system intervention will be more likely to report at least one quit attempt than those in the control condition at months 6, 12, and 18. 4) Participants receiving the interactive expert system intervention will be more likely to have a significant decrease in number of cigarettes smoked than those in the control condition at months 3, 6, 12, and 18. After the intervention adaptation and the pilot testing phase of study procedures, the study will achieve the above aims using a randomized trial targeting 400 Chinese American Smokers with follow-up assessments at 3, 6, 12, and 18 months after baseline.
In 2020, there were approximately 50,865 anal cancer cases and 36,068 penile cancer cases worldwide. HPV is considered the main causal agent for the development of anal cancer and one of the causal agents responsible for the development of penile cancer. The aim of this epidemiological, descriptive, retrospective study was to describe the burden of hospitalization associated with anal neoplasms in men and women and with penis neoplasms in men in Spain from 2016 to 2020. The National Hospital Data Surveillance System of the Ministry of Health, Conjunto Mínimo Básico de Datos, provided the discharge information used in this observational retrospective analysis. A total of 3,542 hospitalizations due to anal cancer and 4,270 hospitalizations due to penile cancer were found; For anal cancer, 57.4% of the hospitalizations occurred in men, and these hospitalizations were also associated with significantly younger mean age, longer hospital stays and greater costs than those in women. HIV was diagnosed in 11.19% of the patients with anal cancer and 1.74% of the patients with penile cancer. The hospitalization rate was 2.07 for men and 1.45 for women per 100,000 in anal cancer and of 4.38 per 100,000 men in penile cancer. The mortality rate was 0.21 for men and 0.12 for women per 100,000 in anal cancer and 0.31 per 100.000 men in penile cancer and the case-fatality rate was 10.07% in men and 8,26% in women for anal cancer and 7.04% in penile cancer. HIV diagnosis significantly increased the cost of hospitalization. For all the studied diagnoses, the median length of hospital stays and hospitalization cost increased with age. Our study offers relevant data on the burden of hospitalization for anal and penile cancer in Spain. This information can be useful for future assessment on the impact of preventive measures, such as screening or vaccination in Spain.
Periprosthetic joint infection (PJI) is a challenging complication that can occur following joint replacement surgery. Efficacious strategies to prevent and treat PJI and its recurrence remain elusive. Commensal bacteria within the gut convey beneficial effects through a defense strategy named "colonization resistance" thereby preventing pathogenic infection along the intestinal surface. This blueprint may be applicable to PJI. The aim is to investigate Lactobacillus acidophilus spp. and their isolated extracellular-derived proteins (LaEPs) on PJI-relevant Staphylococcus aureus, methicillin-resistant S. aureus, and Escherichia coli planktonic growth and biofilm formation in vitro. The effect of LaEPs on cultured macrophages and osteogenic, and adipogenic human bone marrow-derived mesenchymal stem cell differentiation is analyzed. Data show electrostatically-induced probiotic-pathogen species co-aggregation and pathogenic growth inhibition together with LaEP-induced biofilm prevention. LaEPs prime macrophages for enhanced microbial phagocytosis via cathepsin K, reduce lipopolysaccharide-induced DNA damage and receptor activator nuclear factor-kappa B ligand expression, and promote a reparative M2 macrophage morphology under chronic inflammatory conditions. LaEPs also significantly augment bone deposition while abating adipogenesis thus holding promise as a potential multimodal therapeutic strategy. Proteomic analyses highlight high abundance of lysyl endopeptidase, and urocanate reductase. Further, in vivo analyses are warranted to elucidate their role in the prevention and treatment of PJIs.
The safety and effectiveness of Promethazine with Codeine Oral Solution in pediatric patients below the age of 18 have not been established.

Life-threatening respiratory depression and death have occurred in children who received codeine. (See WARNINGS - Ultra-Rapid Metabolism of Codeine and Respiratory Depression). Postmarketing cases of respiratory depression, including fatalities have been reported with use of promethazine in pediatric patients. (See WARNINGS - Promethazine and Respiratory Depression in Children). Because of the risk of life-threatening respiratory depression and death:

  * Promethazine with Codeine Oral Solution is contraindicated in all children younger than age 12 years of age. (See CONTRAINDICATIONS).
  * Promethazine with Codeine Oral Solution is contraindicated for post-operative management in pediatric patients younger than 18 years of age following tonsillectomy and/or adenoidectomy. (See CONTRAINDICATIONS).
  * Avoid the use of Promethazine with Codeine Oral Solution in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine. Risk factors include conditions associated with hypoventilation, such as postoperative status, obstructive sleep apnea, obesity, severe pulmonary disease, neuromuscular disease, and concomitant use of other medications that cause respiratory depression. (See WARNINGS – Ultra-Rapid Metabolism of Codeine and Respiratory Depression).
  * When prescribing codeine for adolescents, healthcare providers should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of morphine overdose. (See OVERDOSAGE).
BACKGROUND: The aim of this study was to examine the characteristics of infant mortality associated with critical congenital heart disease (CCHD).
METHODS: In a cross-sectional study, data for the study were obtained through Death Notification System, Birth Notification System and Turkish Statistical Institute birth statistics.
RESULTS: Of all infant deaths, 9.8% (4083) were associated with CCHD, and the infant mortality rate specific to CCHD was 8.8 per 10,000 live births. CCHD-related infant deaths accounted for 8.0% of all neonatal deaths, while the CCHD specific neonatal death rate was 4.6 per 10,000 live births. Of the deaths 21.7% occurred in the early neonatal, 30.3% in the late neonatal and 48.0% in the post neonatal period. Group 1 diseases accounted for 59.1% (n = 2415) of CCHD related infant deaths, 40.5% (n = 1652) were in Group 2 and 0.4% (n = 16) were in the unspecified group. Hypoplastic left heart syndrome was the most common CCHD among infant deaths (n = 1012; 24.8%). The highest CCHD related mortality rate was found in infants with preterm birth and low birth-weight while multiparity, maternal age ≥ 35 years, twin/triplet pregnancy, male gender, maternal education in secondary school and below, and cesarean delivery were also associated with higher CCHD related infant mortality rate. There was at least one non-cardiac congenital anomaly/genetic disorder in 26.1% of all cases.
CONCLUSION: CCHD holds a significant role in neonatal and infant mortality in Türkiye. To mitigate CCHD-related mortality rates, it is crucial to enhance prenatal diagnosis rates and promote widespread screening for neonatal CCHD.
The invention discloses a three-medicine lung-clearing drink. The three-medicine lung-clearing drink comprises 200-220 g of bulb of fritillary, 140-160 g of herba hedyotidis anriculariae and 240-260 g of bletilla striata and the three medicines are in fine powder form. Each 5-10 g of the lung-clearing drink is taken with plain boiled water for each time. The lung-clearing drink is taken three times a day. When hematemesis is stopped, several rhizoma imperatae decoctions are taken. Beneficial effects of the lung-clearing drink are that: the lung-clearing drink can be used for treating lung heat hemoptysis, hematemesis and vomit for a long time, and the lung-clearing drink has good effects.
This invention relates to use of asiaticoside in preparation of pharmaceutical for treating and preventing diseases, and particularly discloses use of asiaticoside in preparation of pharmaceutical for treating diseases of an object. The diseases are selected from inflammatory bowel disease, piles, anal fissure, fistula, stomach cancer, helicobacter pylori infection or arbitrary combined groups thereof. The pharmaceutical comprises a certain amount of asiaticoside and selectable excipient accepted by one or more pharmaceutical. The invention further discloses use of asiaticoside in preparation of pharmaceutical for preventing diseases of an object. The diseases are selected from colon cancer, stomach illness, stomach cancer, drug induced anabrosis or arbitrary combined groups thereof. The pharmaceutical comprises a certain amount of asiaticoside and selectable excipient accepted by one or more pharmaceutical.
Patients undergo intensity-modulated radiation therapy or 3-dimensional conformal radiation therapy 5 days a week for 6 weeks and receive temozolomide PO QD for up to 7 weeks. Beginning 4 weeks after completion of chemotherapy and radiation therapy, patients receive temozolomide PO QD on days 1-5. Treatment with temozolomide repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. Patients also receive placebo IV over 30-90 minutes once every 2 weeks beginning in week 4 of chemotherapy and radiation therapy and continuing until the completion of temozolomide.
Da Chuanxiong Formula (DCXF) is a traditional herbal prescription used for pain management. It consists of Chuanxiong Rhizoma (CR) and Gastrodiae Rhizoma (GR). Despite its long history of use, the underlying therapeutic mechanism of DCXF remains insufficiently understood. Therefore, in this study, key target genes were obtained through network pharmacology research methods and molecular docking techniques, including transient receptor potential vanilloid 1 (TRPV1), adenosine A2a receptor (ADORA2A), nuclear receptor subfamily 3 group C member 1 (NR3C1), and protein kinase C beta (PRKCB). Molecular dynamics simulations demonstrated the favorable binding between all four key genes and their corresponding compounds. Notably, chronic constriction injury (CCI) treatment resulted in a significant decrease in mechanical threshold and thermal latency period for rat foot contraction, which was ameliorated upon administration of DCXF. Furthermore, real-time quantitative reverse transcription PCR (RT-qPCR) and western blot (WB) analyses indicated an upregulation of TRPV1, ADORA2A, NR3C1, and PRKCB expression in the rat dorsal root ganglion following CCI, which was attenuated by treatment with DCXF. The expressions of inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6), in the rat dorsal root ganglion were assessed using ELISA, confirming consistent trends with the aforementioned findings. The results of this study offer a promising theoretical foundation for the utilization of DCXF in the treatment of neuropathic pain (NP).
Prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET) imaging allows early detection of metastases in patients with biochemical recurrence. Salvage lymphadenectomy became a widely used method of metastasis-directed treatment. Retrospective analyses show that a low prostate-specific antigen (PSA) value and presence of no more than two affected lymph nodes within the pelvis are factors associated with a good outcome. In all, 40-80% of patients achieve a complete biochemical response with a mean time without biochemical recurrence of 8 months and a prolonged treatment-free interval. About 10% of patients with a complete biochemical response will live without recurrence after 10 years. The utilization of PSMA-radioguided surgery increases the likelihood of intraoperative detection of suspicious affected lymph nodes. Complications can mostly be avoided by prudent patient selection and surgical expertise.
PROBLEM TO BE SOLVED: To obtain an effective new osteoclast-formation inhibitor by including interleukin 18 or its functional derivative. SOLUTION: This osteoclast-formation inhibitor includes interleukin 18(IL-18) or its functional derivative. The IL-18 is exemplified by IL-18 having amino acid sequence of the formula. The objective inhibitor is used in a form of a liquid, a paste or a solid containing 0.0002-0.5%(W/W). The objective inhibitor is preferably administered in 2-6 time doses per day of 2μg to 10mg divided dose of IL-18, or in 2-10 time doses per week for one day to one year. The objective inhibitor is useful as a medium component for cell culture and further manifests effects as a bone resorption modifier and a treating and preventing agent for a disease corresponding to osteoclast such as hypercalcemia because the inhibitor extremely inhibits the formation of osteoclast.