anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a composition, readily fillable in a root canal and simultaneously easily hardenable and convertible into apatite after filling in the root canal without being absorbed in the living body, excellent in biocompatibility, having no irritanty and suitable as a paste root canal filler. CONSTITUTION:This dental hardenable composition comprises (A) calcium phosphate, preferably having 1.3-2.0 atomic ratio of Ca/P, especially tricalcium alpha-phosphate, (B) an X-ray contrast medium, bismuth subcarbonate, barium sulfate or iodoform, (C) a fluorine compound for accelerating the hardening of a root canal filler and conversion of the calcium phosphate into apatite, preferably a water-soluble fluorine compound such as KF, NaFHF or a monofluorophosphate and (D) a condensed phosphoric acid or its salt, preferably pyrophosphoric acid (salt). The amounts of the ingredients are 0.01-0.6mol ingredient (C) expressed in terms of fluorine based on 1mol ingredient (A), 0.005-0.5mol ingredient (D) based on 1mol ingredient (A) and 5-100 pts.wt. ingredient (B) based on 100 pts.wt. ingredient (A). The viscosity of the slurry is reduced to improve the operating efficiency by blending the ingredient (D).
PFDMO2OA (C8 HFPO-TA), a novel substitute for perfluorooctanoic acid (PFOA), has been frequently detected in surface waters. However, information on its toxicity remains scarce. In the present study, zebrafish embryos were exposed to varying concentrations of PFDMO2OA, ranging from 80 to 800 mg/L, until 120 h post-fertilization (hpf) to explore its potential developmental toxicities. The LC50 value for mortality was 505.9 mg/L, comparable to that of PFOA (over 500 mg/L), suggesting a lack of safety of PFDMO2OA compared to PFOA. At 120 hpf, PFDMO2OA exposure led to various malformations in embryos, including uninflated swim bladder, yolk sac oedema, spinal deformation, and pigmentation changes, with pericardial oedema being prominent. Analysis using O-dianisidine stain indicated a decline in erythrocytes over time. Transcriptome analysis further revealed the cardiovascular toxicity caused by PFDMO2OA at the molecular level. Time-course differential analysis pointed to the apoptosis dependent on disrupted mitochondrial function as a significant contributor to erythrocyte disappearance, as confirmed by the TUNEL stain. Therefore, the present findings suggest that PFDMO2OA induces developmental malformations and cardiovascular toxicities in zebrafish embryos, demonstrating a toxic potency comparable to that of PFOA. The results further highlight the significance of evaluating the health risks associated with PFDMO2OA.
Patients will receive the standard type of treatment decided by the attending physicians. They will also receive 20ml (10ml for patients with creatinine clearance lower than 30ml/min) intravenous (IV) 0.9% saline (N/S) three times daily (every eight hours) for 15 days and 0.5 ml subcutaneous (sc) 1ml 0.9% N/S every other day for a total of 15 days.
OBJECTIVE: Hearing loss is increasingly prevalent among younger adults, impacting health and health care use. Deaf and hard of hearing (DHH) women have a higher risk of chronic diseases, pregnancy complications, and adverse birth outcomes compared with hearing women. Health care utilization patterns during the perinatal period remain not well understood. The objective of this study was to examine differences in antenatal emergency department and inpatient utilization among DHH and non-DHH women.
STUDY DESIGN: We conducted a retrospective cohort study design to analyze 2002 to 2013 Massachusetts Pregnancy to Early Life Longitudinal data to compare antenatal inpatient and emergency department use between DHH (N = 925) and hearing (N = 2,895) women with singleton deliveries. Matching was done based on delivery year, age at delivery, and birth parity in 1:3 case-control ratio. Demographic, socioeconomic, clinical, and hospital characteristics were first compared for DHH mothers and the matched control group using chi-squared tests and t-tests. Multivariable models were adjusted for sociodemographic and clinical characteristics.
RESULTS: Among DHH women (N = 925), 49% had at least one emergency department visit, 19% had an observational stay, and 14% had a nondelivery hospital stay compared with 26, 14, and 6%, respectively, among hearing women (N = 28,95) during the antenatal period (all ps < 0.001). The risk of nondelivery emergency department visits (risk ratio [RR] 1.58; p < 0.001) and inpatient stays (RR = 1.89; p < 0.001) remained higher among DHH women compared with hearing women even after adjustment. Having four or more antenatal emergency department visits (7 vs. 2%) and two or more nondelivery hospital stays (4 vs. 0.4%) were more common among pregnant DHH women compared with their controls (all p-values < 0.001).
CONCLUSION: The findings demonstrate that DHH women use emergency departments and inpatient services at a significantly higher rate than their hearing controls during the antenatal period. A systematic investigation of the mechanisms for these findings are needed.
KEY POINTS: · Antenatal emergency department use is significantly higher among deaf and hard of hearing women.. · Antenatal hospitalizations are significantly higher among deaf and hard of hearing women.. · Hearing loss screening may identify those at risk for adverse pregnancy and birth outcomes..
CYH33 in Combination with Olaparib; 20 mg CYH33 QD in combination with olaparib 300 mg BID. Additional dose levels of CYH33 at20 and 30 mg QD and CYH33 at 40 mg QD in combination with olaparib 200 mg BID will be evaluated.
A medicine for curing cholelithiasis adopts more than ten natural Chinese herbal medicines such as loosestrife, absinthin, gardenia, saltpeter, mirabilite, bitter orange, curcuma longa, magnolia officinalis, rhizoma corydalis, scutellaria, bupleurum, dried alum, pinellia ternate, white peony root, galli stomachichum corium, honeysuckle, dandelion, chinaberry fruit, pangolin and the like. The medicines are compounded scientifically and reasonably so that the efficacy of each medicine generates a cooperative function, the compounding way is unique and the compounding is strict. The four following steps, such as dissolving, moving, washing and discharging, can be summarized for curing cholelithiasis, and the medicine overcomes the defects that the existing medicine for curing cholelithiasis has long medicine-taking time, slow stone elimination speed, low effective rate and recrudescence after treatment. The medicine takes 20 days as one treatment course and the patient with the disease of cholelithiasis can be generally cured after 1-2 treatment courses. The effective rate achieves more than 98% and the curative rate achieves more than 94%. The medicine has the advantages of quick effect, short period of treatment, high curative rate, no toxicity, safety, reliability and the like; furthermore, the raw material has rich source, the fabrication method is simple, the cost is low and the medicine is the preferably selected medicine for the wide patients with the disease of cholelithiasis.
The invention discloses a zirconium dioxide composite nanometer material with microwave sensitization, chemotherapy dry release and CT imaging functions and a preparation method and application thereof. The zirconium dioxide composite nanometer material comprises a hollow zirconium dioxide nanometer material and trametes polysaccharide. The hollow part of the zirconium dioxide nanometer material of the zirconium dioxide composite nanometer material is filled with the trametes polysaccharide. The grain size of the zirconium dioxide composite nanometer material is 50-500 nm; the thickness of a shell is 10-100 nm. The prepared zirconium dioxide composite nanometer material is good in dispersity; the size and thickness of the shell can be adjusted as needed. The hollow part of the zirconium dioxide is filled with the traditional Chinese medicine trametes polysaccharide with the chemotherapy effect for the first time; the zirconium dioxide composite nanometer material can be applied to the technical fields of microwave sensitization, chemotherapy dry release and CT imaging at the same time, achieves the target of treating the tumor through the diagnosis and treatment integration and targeted hyperthermia chemotherapy and has good clinical application prospects.
A systematic investigation of an outbreak of postoperative sepsis in nine patients following surgery in the operating rooms of a primary-type hospital between November 26 and 28, 2018 was conducted to determine the extent of the outbreak, the vehicle, and the route of transmission. The comprehensive investigation included epidemiological, microbiological, molecular biological, and environmental methods. A retrospective cohort study was used to find associations between individual exposure factors and outcomes, the respective septic conditions. Nine of 24 surgery patients were infected (AR 37.5 %). An identical strain of Acinetobacter calcoaceticus was found in biological specimens of two infected patients. The combined investigation did not reveal the vector or route of transmission. Immediate infection prevention and control measures avoided new cases of postoperative sepsis.
BACKGROUND: Chronic gastritis caused by Helicobacter pylori (Hp) infection is a common gastrointestinal disorder. Despite the high prevalence of Hp infection and chronic gastritis in the Tibetan Plateau, there is a lack of studies elucidating the influence of plateau hypoxia on Hp-induced gastritis. This study aimed to investigate the impact of high-altitude hypoxia on Hp-induced gastritis, particularly focusing on pathological manifestations and inflammatory responses.
METHODS: This study was conducted from July 2023 to March 2024 at the Department of Gastroenterology, Affiliated Hospital of Qinghai University. Ninety patients diagnosed with chronic gastritis were enrolled in the study and divided into four groups based on their residential altitude and Hp infection status. Data on endoscopic and pathological characteristics were collected, along with serum oxidative stress and inflammatory markers.
RESULTS: Patients with Hp gastritis exhibit distinctive features in the gastric mucosa, including diffuse erythema, enlarged folds, and white turbid mucus during endoscopy. Notably, individuals with Hp gastritis at high altitudes show a higher prevalence of diffuse erythema and enlarged folds. Pathological analysis reveals that these patients have elevated gastric mucosal inflammation scores and increased chronic and active inflammation. Furthermore, individuals with Hp gastritis at high altitudes demonstrate elevated levels of serum TNF-α, IL-1β, IL-6, and MDA, as well as reduced serum SOD and GSH-Px activities.
CONCLUSIONS: High-altitude hypoxia may exacerbate gastric mucosal damage by enhancing oxidative stress and inflammatory response induced by Hp infection.
PURPOSE: To produce a nonionic surfactant by adding a specific ratio of monochlorohydrin of glycerol at <=150 deg.C in the presence of an arom. solvent and strong base to a polyhydroxyl org. compd. and effecting the condensation reaction of the mixture. CONSTITUTION: While the monochlorohydrin of the glycerol is condensed in the presence of an arom. solvent and a strong base with the polyhydroxyl org. compd. selected from the group consisting of alkyl phenol, 1, 2-alkane diol, polyethyoxylated aliphat. alcohol and polyethoxylated ether, the water is removed by distillation, by which the reaction is effected. This condensation reaction is effected at <=150 deg.C and the molar ratio of the monochlorohydrin of the glycerol to the polyhydroxyl org. compd. is specified to >=1, by which the polyglycerolated surfactant soluble or dispersible in the water is produced.
This cohort includes participants who received first bilateral lung transplantation from 2017 to 2020. The immune checkpoints analyses will be conducted on stored specimens from postoperative transbronchial biopsy performed for clinical suspicious of rejection.
STUDY DESIGN: Retrospective cohort.
OBJECTIVE: The aim was to compare patient-reported outcomes (PROMs), minimum clinically important difference (MCID) achievement, and postoperative satisfaction following minimally invasive lumbar decompression in patients stratified by American Society of Anesthesiologists (ASA) classification.
SUMMARY OF BACKGROUND DATA: Some guidelines recommend against performing elective procedures for patients with an ASA score of 3 or greater; however, long-term postoperative outcomes are not well described.
METHODS: Primary, single-level, minimally invasive lumbar decompression procedures were identified. PROMs were administered at preoperative, 6-week, 12-week, 6-month, 1-year, 2-year timepoints and included Patient-Reported Outcomes Measurement Information System-Physical Function, visual analog scale (VAS) back/leg, Oswestry disability index (ODI), and 12-item short form physical component score. Satisfaction scores were collected postoperatively for VAS back/leg, ODI, and individual ODI subcategories. Patients were grouped (ASA<3, ASA≥3), and propensity scores were matched to control for significant differences. Demographic and perioperative characteristics were compared using χ 2 and the Student's t test. Mean PROMs and postoperative satisfaction were compared at each time point by a 2-sample t test. Postoperative PROM improvement from the preoperative baseline within each cohort was calculated with a paired t test. MCID achievement was determined by comparing ΔPROMs to established thresholds and comparing between groups using simple logistic regression.
RESULTS: One hundred and twenty-nine propensity-matched patients were included: 99 ASA<3 and 30 ASA≥3. No significant demographic differences were observed between groups. ASA≥3 patients experienced significantly increased length of stay and postoperative narcotic consumption on surgery day ( P <0.048, all). Mean PROMs and MCID achievement did not differ. The ASA<3 cohort significantly improved from the preoperative baseline for all PROMs at all postoperative time points. ASA<3 patients demonstrated higher levels of postoperative satisfaction at 6 weeks for VAS leg, VAS back, ODI, sleeping, lifting, walking, standing, sex, travel, and at 6 months for VAS back ( P <0.045, all).
CONCLUSION: ASA≥3 patients may achieve similar long-term clinical outcomes to ASA<3 patients, though they may show poorer short-term satisfaction for disability, leg pain, and back pain, which could be related to differing preoperative expectations.
β-Caryophyllene (BCP), a dietary phytocannabinoid, significantly suppresses palmitate-induced lipid accumulation in human HepG2 hepatocytes via activation of AMP-activated protein kinase (AMPK) signaling. The objective of the preset research was to assess whether oral administration of BCP alleviates obesity-induced hepatic steatosis in mice through AMPK activation. We examined the protective action of supplementation of 0.3% BCP (w/w) in a high-fat diet (HFD) on C57BL/6J mice for 12 weeks. BCP supplementation evidently ameliorated histological hepatic steatosis features, and significantly reduced triglycerides and cholesterol levels in the liver, and serum levels of aspartate aminotransferase and alanine aminotransferase as compared with non-supplemented HFD-fed mice. Immunoblotting revealed that BCP supplementation in HFD-fed mice also caused hepatic AMPK activation. Furthermore, treatment with BCP in HFD-fed mice significantly suppressed body weight gain and attenuated obesity-related phenotypes relative to the HFD mice. Our results suggest the usefulness of BCP in the prevention of obesity-related liver steatosis and liver injury.
INTRODUCTION: Cerebral ischemia-reperfusion injury (CIRI) is a common and debilitating complication of cerebrovascular diseases such as stroke, characterized by mitochondrial dysfunction and cell apoptosis. Unraveling the molecular mechanisms behind these processes is essential for developing effective CIRI treatments. This study investigates the role of RACK1 (receptor for activated C kinase 1) in CIRI and its impact on mitochondrial autophagy.
METHODS: We utilized high-throughput transcriptome sequencing and weighted gene co-expression network analysis (WGCNA) to identify core genes associated with CIRI. In vitro experiments used human neuroblastoma SK-N-SH cells subjected to oxygen and glucose deprivation (OGD) to simulate ischemia, followed by reperfusion (OGD/R). RACK1 knockout cells were created using CRISPR/Cas9 technology, and cell viability, apoptosis, and mitochondrial function were assessed. In vivo experiments involved middle cerebral artery occlusion/reperfusion (MCAO/R) surgery in rats, evaluating neurological function and cell apoptosis.
RESULTS: Our findings revealed that RACK1 expression increases during CIRI and is protective by regulating mitochondrial autophagy through the PINK1/Parkin pathway. In vitro, RACK1 knockout exacerbated cell apoptosis, while overexpression of RACK1 reversed this process, enhancing mitochondrial function. In vivo, RACK1 overexpression reduced cerebral infarct volume and improved neurological deficits. The regulatory role of RACK1 depended on the PINK1/Parkin pathway, with RACK1 knockout inhibiting PINK1 and Parkin expression, while RACK1 overexpression restored them.
CONCLUSION: This study demonstrates that RACK1 safeguards against neural damage in CIRI by promoting mitochondrial autophagy through the PINK1/Parkin pathway. These findings offer crucial insights into the regulation of mitochondrial autophagy and cell apoptosis by RACK1, providing a promising foundation for future CIRI treatments.
1,143,440. Dexamethasone aerosol composition for inhalation therapy. MERCK & CO., Inc. 21 July, 1966, No. 32863/66. Heading A5B. [Also in Division C4] An aerosol composition for inhalation therapy consists of 0.001-0.18% by wt. anhydrous disodium dexamethasone phosphate of 1-10Á particle size, 0.01-2% by wt. sorbitan trioleate as a dispersing agent, the balance of the composition, excluding additional medicaments optionally present in an amount up to 2% by wt., being a non-toxic liquid propellant having a vapour pressure of 15-70 p.s.i.g. at 70‹F. Specified propellants are fluorinated or fluorochlorinated C 1-4  saturated aliphatic hydrocarbons, or mixtures thereof. Other non- toxic propellants having a vapour pressure outside the above limits may be used in admixture with one or more propellants having a vapour pressure within the above range provided that the vapour pressure of such mixtures is within the above limits.
Metabolic syndrome is a risk factor for diabetes mellitus characterized by insulin resistance, hypertension, triglyceride elevation, low levels of high-density lipoproteins, and obesity. Metformin and rosiglitazone are two insulinosensensitizers used in the treatment of diabetes. Now there is controversy over the use of insulinossensitizers in non-diabetic patients with metabolic syndrome. To compare the effect of insulin sensitizing drugs (metformin and rosiglitazone) over glucose homeostasis (GH) in no diabetic metabolic syndrome individuals. Randomized blinded clinical trial in patients with metabolic syndrome without diabetes was done, sample size (n=30). Prior to detailed information and signature of informed consent by patients was randomized forming three treatment groups, a) Placebo, b) Metformin (850 mg/day), c) Rosiglitazone (4 mg/day), treatment was administered for 8 weeks. GH was measured before and after treatment using oral glucose tolerance test (OGTT), and IR-index (Homeostatic Model). Determination was performed on weight, size, body mass index, plicometry, blood pressure, fasting glucose levels, triglycerides, HDL-cholesterol and insulin. Statistic no parametric (Kruskal Wallis, Wilcoxon, U Mann Whitney) to compare characteristics inter o intra groups was done. Exact Fisher test was used for qualitative variable, and consider significance with p\<0.05.
The present disclosure provides an Aralia armata (Wall.) Seem— derived total saponin and use thereof in preparation of a drug for treating post—vascular injury restenosis. In the present disclosure, a coarse powder of an Aralia armata (Wall.) Seem dry root bark is subjected to reflux extraction by a 70—80% ethanol aqueous solution, an extracting solution is extracted by petroleum ether, dichloromethane or chloroform and water—saturated n— butanol, the n—butanol as a solvent is removed from a supernatant, and the supernatant is evaporated to dryness to obtain the Aralia armata (Wall.) Seem—derived total saponin. The Aralia armata (Wall.) Seem—derived total saponin can effectively inhibit vascular intimal hyperplasia, inhibit proliferation and/or metastasis of vascular smooth muscle cells (VSMCs), and inhibit expression of a protein molecule in a Wnt signaling pathway. Therefore, the Aralia armata (Wall.) Seem—derived total saponin can be used in preparation of the drug for treating post—vascular injury restenosis.
1471465 Vaginal medicator H H GROVES 4 June 1974 24685/74 Heading A5R A vaginal medicator, Figs. 1d and 1b, comprises an elongated stem 12 of non-soluble material which carries medicament 22, for extending along substantially the entire length of the vaginal canal to the cervix, a non- soluble anchoring moss 14 for retention outwardly of the constricting muscles at the entrance to the vaginal canal and a pullout string 16. The anchoring moss may be either spherical or cylindrical, and the pullout string may be replaced by an extension of the stem through the anchoring moss. The stem and the anchoring moss may each be hollow and liquid permeable, for housing the medicament Fig. 7d, the stem may be looped for encircling the cervix, Figs. 7d, 9b and may additionally carry a web 60, Fig. 9b, for carrying the medicament.
In a transdermal drug delivery system (10), encapsulation material used to coat drug granules (24) controls the release of an active ingredient.  The active ingredient is released into a water retaining matrix (20), which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell (12) which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators (28) incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.
Obesity is among the risk factors for male infertility. Although several mechanisms underlying obesity-induced male subfertility have been reported, the entire mechanism of obesity-induced male infertility still remains unclear. Here, we show that sperm count, sperm motility and sperm fertilizing ability were decreased in male mice fed a high-fat diet and that the expression of the AdipoR1 gene and protein was decreased, and the expression of pro-apoptotic genes and protein increased, in the testis from mice fed a high-fat diet. Moreover, we demonstrate that testes weight, sperm count, sperm motility and sperm fertilizing ability were significantly decreased in AdipoR1 knockout mice compared to those in wild-type mice; furthermore, the phosphorylation of AMPK was decreased, and the expression of pro-apoptotic genes and proteins, caspase-6 activity and pathologically apoptotic seminiferous tubules were increased, in the testis from AdipoR1 knockout mice. Furthermore, study findings show that orally administrated AdipoRon decreased caspase-6 activity and apoptotic seminiferous tubules in the testis, thus ameliorating sperm motility in male mice fed a high-fat diet. This was the first study to demonstrate that decreased AdipoR1/AMPK signaling led to increased caspase-6 activity/increased apoptosis in the testis thus likely accounting for male infertility.