anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The incidence of chronic diseases and conditions including cancer that require a long-term treatment process and also affect the individual psychological status and quality of life has increased with a high financial burden as a result of relatively prolonged human life under the influence of contemporary medicine. Palliative care services can be applied in chronic, life-threatening conditions such as cancer, and provide physical, mental and psychological support to patients worldwide. Symptoms including pain, constipation, diarrhea, anorexia, dysphagia, nausea and vomiting, dehydration, depression, delirium, and fatigue may demonstrate in cancer patients receiving palliative care, while most of the them have complain of pain. Studies have reported that 30% of cancer patients experienced pain at the diagnosis, 50-70% of them in during treatment period, and 60-80% of them in the terminal period. It was determined in another study that 90% of patients had pain when they were hospitalized in palliative care service, and more than half of them defined the pain severity at 5 and above.

Pharmacological agents were used to manage pain control, as they had rapid effect and were easily applicable. In addition to pharmacological agents, the application of non-pharmacological interventions is important for improving the quality of life and patient comfort and reducing the symptom burden in relieving pain caused by the side effects and methods of treatment in the palliative care cancer patients. Since non-pharmacological methods could reduce pain by applying alone or in combination with drugs, the frequency of use has increased in recent years. Music therapy was used as a non-pharmacological method in many health problems as a traditional treatment and psychosocial interventions. The study was aimed to investigate the effects of music therapy on pain in patients with cancer hospitalized palliative care service. In the current study we tested the hypothesis that palliative care patients' pain management. 1. reduce the rate of pain score. 2. reduce the rate of anxiety scoe. 3. To increase the rate of comfort level. 4. To increase the rate of functional capacity.
Exploring the intricate pathogenesis of Vascular Dementia (VD), there is a noted absence of potent treatments available in the current medical landscape. A new brain-protective medication developed in China, Edaravone dexboeol (EDB), has shown promise due to its antioxidant and anti-inflammatory properties, albeit with a need for additional research to elucidate its role and mechanisms in VD contexts. In a research setup, a VD model was established utilizing Sprague-Dawley (SD) rats, subjected to permanent bilateral typical carotid artery occlusion (2VO). Behavioral assessment of the rats was conducted using the Bederson test and pole climbing test, while cognitive abilities, particularly learning and memory, were evaluated via the novel object recognition test and the Morris water maze test. Ensuing, the levels of malondialdehyde (MDA), superoxide dismutase (SOD), IL-1β, IL-6, IL-4, and tumor necrosis factor-α (TNF-α) were determined through Enzyme-Linked Immunosorbent Assay (ELISA). Synaptic plasticity-related proteins, synaptophysin (SYP), post-synaptic density protein 95 (PSD-95), and N-methyl-D-aspartate (NMDA) receptor proteins (NR1, NR2A, NR2B) were investigated via Western blotting technique. The findings imply that EDB has the potential to ameliorate cognitive deficiencies, attributed to VD, by mitigating oxidative stress, dampening inflammatory responses, and modulating the NMDA receptor signaling pathway, furnishing new perspectives into EDB's mechanism and proposing potential avenues for therapeutic strategies in managing VD.
Concomitantly with the BIA 6-512/Placebo dose, subjects will be administered levodopa/benserazide 100/25 mg. All subjects attended to each 5 treatment periods and received a different dose of BIA 6-512 or placebo in combination with a single-dose of controlled release levodopa/benserazide 100/25 mg in each of these treatment periods. The washout period between periods was 5 days or more.
PURPOSE: This study aimed to assess the clinical outcome and safety of holmium laser enucleation of the prostate (HoLEP) following transrectal ultrasound-guided prostate biopsy (TR biopsy) in the treatment of benign prostate hyperplasia.
MATERIALS AND METHODS: We retrospectively analyzed data from 556 patients who underwent HoLEP between 2014 and 2021. The patients were categorized into six groups: Group 1-A (n=45) underwent HoLEP within four months post TR biopsy. Group 1-B (n=94) underwent HoLEP more than four months post TR biopsy. Group 1-C (n=120) underwent HoLEP after a single TR biopsy. Group 1-D (n=19) underwent HoLEP after two or more TR biopsies. Group 1-total (n=139, group 1-A+group 1-B or group 1-C+group 1-D) underwent HoLEP post TR biopsy. Group 2 (control group, n=417) underwent HoLEP without prior TR biopsy. We examined perioperative parameters, safety, and functional outcomes.
RESULTS: The age, body mass index, International Prostate Symptom Score (IPSS), uroflowmetry, and comorbid diseases between group 1-total and group 2 were comparable. However, group 1-total exhibited significantly elevated prostate-specific antigen levels and larger prostate volumes (p<0.01). Perioperative factors like enucleation time, enucleation weight, and catheterization duration were notably higher in group 1-total (p<0.01). All groups showed significant improvements in IPSS, postvoid residual urine, and maximum flow rate during the 1-year postoperative period (p<0.05). The rates of postoperative complications were similar between group 1-total and group 2.
CONCLUSIONS: Enucleation time and catheterization duration were significantly longer in the TR biopsy group. However, postoperative complications were not significantly different between TR biopsy and non-TR biopsy groups.
Selected patients with Parkinson's disease were randomly divided into a therapy group and a control group. Umbilical Cord Derived Mesenchymal Stem Cells(UC-MSCs) at a dose of 10-20 million by intravenous infusion.Patients in the therapy group treated once a week with UC-MSCs. Each course of treatment Lasted 3 weeks.
Optimal cytoreduction, particularly in advanced cases, significantly extends 5-year survival compared to cases with residual disease exceeding 1 cm. Consequently, ultra-radical tumor cytoreduction procedures, commonly performed in advanced ovarian cancer, entail the excision of abdominopelvic tissues affected by the primary ovarian malignancy, including segments of the bowel, bladder, spleen, gallbladder, diaphragm, and other organs. Rectosigmoid resection (RSR) emerges as the predominant bowel resection, followed by colon and small bowel resections. Intestinal anastomosis post-RSR is indispensable for bowel reconstruction but bears a notable risk of postoperative anastomotic fistula (AL), a major complication. AL incidence rates fluctuate over time, reported between 8-14% in OC surgery patients undergoing RSR.

AL imposes considerable burdens, encompassing elevated hospital costs, prolonged stays, heightened rates of secondary admissions and surgeries, and mortality rates ranging from 3% to 21%. Furthermore, AL delays the commencement of adjuvant chemotherapy, detrimentally impacting overall survival and representing a significant consequence of colorectal surgery.
PROBLEM TO BE SOLVED: To obtain the subject scavenger expressing excellent nitrogen monoxide-scavenging action, excellent in inflammation-inhibiting effects, highly safe to the skin and having excellent preservation stability by bringing the scavenger to contain a specific aromatic compound. SOLUTION: This scavenger contains a compound of the formula (R is H or a sugar residue). The sugar residue of R1 is a reducing monosaccharide or oligosaccharide, e.g. a monosaccharide such as glucose, galactose, xylose, mannose and N-acetylglucosamine and the like and a disaccharide such as maltose, cellobiose, gentiobiose and the like are cited. The compound of the formula is called raspberry ketone or raspberry ketone glycoside. As the glycoside, raspberry ketone-D-glucoside, raspberry ketone-D-galactoside, raspberry ketone-D-xyloside, raspberry ketone-D-maltoside and the like (all in αand β form) are cited. The cosmetic material is obtained by including the nitrogen monoxide scavenger.
The present invention relates to a pure traditional Chinese medicine preparation, namely a pile-treating suppository (ointment) for treating pile and a preparing method thereof. The prescription of the preparation comprises keel, boneol, coptis, arnebia root, Chinese gall, mint and borax, and the medicaments are pulverized to more than 100 meshes. When the suppository is prepared, cocoa butter which is as 4 times as the medicaments is added. When the ointment is prepared, vaseline which is as 4 times as the medicaments is added. The disinfection is carried out by ultraviolet radiation. The pile-treating suppository (ointment) has the advantages of convenient preparation method, anuses administration and good treatment effect. The pile-treating suppository (ointment) can be used for treating internal pile, external pile, mixed pile, and also has good treatment effect on diseases of anus fissure, rectitis, colonitis, etc.
Antibiotic-induced dysbiosis in the fish gut causes significant adverse effects. We use fecal microbiota transplantation (FMT) to accelerate the restoration of florfenicol-perturbed intestinal microbiota in koi carp, identifying key bacterial populations and metabolites involved in the recovery process through microbiome and metabolome analyses. We demonstrate that florfenicol disrupts intestinal microbiota, reducing beneficial genera such as Lactobacillus, Bifidobacterium, Bacteroides, Romboutsia, and Faecalibacterium, and causing mucosal injuries. Key metabolites, including aromatic amino acids and glutathione-related compounds, are diminished. We show that FMT effectively restores microbial populations, repairs intestinal damage, and normalizes critical metabolites, while natural recovery is less effective. Spearman correlation analyses reveal strong associations between the identified bacterial genera and the levels of aromatic amino acids and glutathione-related metabolites. This study underscores the potential of FMT to counteract antibiotic-induced dysbiosis and maintain fish intestinal health. The restored microbiota and normalized metabolites provide a basis for developing personalized probiotic therapies for fish.
The invention discloses a 2h-pyrazole sulfanilamide steroid saponin aglycone derivative containing indole framework and a preparation method and application thereof. The structure of the 2h-pyrazole sulfanilamide steroid saponin aglycone derivative containing the indole framework is shown as the formula VII in the specification. R1 is selected from H, CH3 and CH2CH3. R2 is selected from H, CH3, CH2CH3, F, C1 and Br. R3 is selected from H and CH3. R4 is selected from H and CH3. The 2h-pyrazole sulfanilamide steroid saponin aglycone derivative has a remarkable restraint effect on breast cancer cells (MCF-7), cervical cancer cells (HeLa), lung cancer cells (A549) and hepatoma cancer cells (HepG2) of human body, has identical or superior cell toxicity to human renal epithelial cells (293T) compared with a positive reference drug (Celecoxib), has better biological cavity, higher selectivity and lower toxicity, and can be used for preparing anti-cancer drugs.
All included children are treated with a face-to-face exposure-based cognitive behaviour therapy for 10 weeks. There will be no comparison arm.
Participants will receive treatment B, on Day 1 of Intervention Period 1 followed by treatment A, on Day 1 of Intervention Period 2 followed by treatment B, Day 1 of Intervention Period 3 and then followed by treatment A, on Day 1 of Intervention Period 4. Each intervention Period will be separated by a washout period of 7-9 days.
The invention belongs to the technical field of medical care, and particularly relates to a medical pillow for treating chronic bronchitis. The medical pillow for treating chronic bronchitis comprises a pillow body, and conical protrusions corresponding to acupuncture points of the head are arranged on the upper surface of the pillow body. A medicine bag is arranged in the pillow body, and the medicine bag extends into the conical protrusions. The medicine bag is filled with medicine liquid. The medicine liquid comprises, by weight, the following raw materials: white mustard seed, divaricate saposhnikovia root, rhizoma atractylodis macrocephalae, cassia twig, peppermint, incised notopterygium rhizome, radix platycodonis, herba asari and radix astragali. A heating wire is arranged in the medicine bag. A temperature control switch is arranged on the outer side of the pillow body. The medicine liquid in the medical pillow is mild in medicine property, has no side effect, and does not cause harm to the human body. When a patient sleeps, the medical pillow can treat chronic bronchitis and the patient does not need to waste time and energy. In addition, radical cure for chronic bronchitis can be achieved by using the medical pillow for treating chronic bronchitis for a long time.
PURPOSE: To prevent the cloudiness of a preserving container by suppressing the sublimation of ibuprofen in a solid preparation. CONSTITUTION: Ibuprofen-containing solid preparation and a desiccant are preserved in a closed system. One or more selected from silica gel, silica alumina gel, calcium chloride, quicklime, etc., are used as the desiccant and the amount of it used is 0.01-0.5 pt.wt., preferably 0.05-0.2 pt.wt. based on 1 pt.wt. of a tablet. A bottle or a can made of glass, plastic, metal, etc., or a container of PTP, etc., is used as the container used in preservation in a closed system. Ibuprofen has a chemical name of (±)-2-(p-isobutylphenyl)propionic acid and is useful as an anti-inflammatory agent.
The surgical technique in coronally advanced flap with subepithelial connective tissue graft (CTG+CAF) group was "envelope technique" as described by Raetzke. The papillae were dis epithelialized. The root was planned and hard accumulations were removed but no chemical root treatment was performed. The connective tissue graft was harvested from the palate using "trap-door technique" described by Edel. Epithelial layer was elevated with a horizontal and two vertical incisions. The connective tissue graft was harvested as 1 mm by using a standard caliper, then epithelial layer was sutured by resorbable suture. The connective tissue graft was sutured to the recipient bed by resorbable suture at the level of CEJ.
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient. In some embodiments, the at least one agonist of GHRH is administered pre-transplantation, concurrently with transplantation, post-transplantation or any combinations thereof.
Phase 2 will be an observational study of patients assessed before and after the clinical initiation of triple-combination modulator therapy (after presumed FDA and Health Canada approval). The primary endpoint for Phase 2 is the change of VDP after 28 days of triple-combination modulator therapy. Within Phase 2, this study will also address how highly-effective modulator therapies affect lung function trajectories by measuring 129Xe MRI at 28 days (± 7 days), 6 months (± 28 days), and 12 months (± 28 days) after start of therapy (paralleling time points of the PROMISE study). Finally, to understand how 129Xe MRI can be used in combination with existing measures of lung function (e.g. spirometry, multiple breath washout), the investigators will directly compare the repeated data collected in both Phase 1 and Phase 2 to these established measures of lung function that are currently used in observational and interventional studies.
PURPOSE:To assay an adult type T leukemia (ATL) antibody quickly and accurately employing a non-soluble antigen in which one or more kinds of a soluble cytoplasmic protein (SCP) of an ATL cell and a solubly treated protein (VAP) are fixed to a non-soluble support body. CONSTITUTION:An ATL cell is cultivated and homogenated and then, centrifuged to obtain SCP from the supernatant thereof. On the other hand, the sediments obtained by centrifugal separation are treated to produce a VAP of the ATL virus. One or both of the SCP and VCP are fixed to a porous bead-like carrier made of polystylene and glass to make a non-soluble antigen. Serum of a patient which was cultivated and diluted is added to the non-soluble antigen. This enables an accurate assay of an antibody related to ATL for a number of serums to be inspected at a time easily and quickly by use of a fluorescent or enzymatic immunoassay as widely accepted method. Thus, this serves for the diagnosis and screening of ATL patients.
The invention discloses a kind of neuropeptide and its synthetic method and application, the neuropeptide has SEQ ID NO:Amino acid sequence shown in 1.According to SEQ ID NO:Amino acid sequence shown in 1, using valine as first amino acid, by its NH 2 It is exposed, then with second COOH condensation of amino acids Arginine, amido link is formed, remaining amino acid is sequentially connected like this, tyrosine is finally connected, obtain final product the neuropeptide.Relative to prior art, the invention has the advantages that：1. this product can be effectively improved the defect of the social memory of experimental animal, and not observe adverse reaction；2. this product functional area is one section of sequence on endogenous protein, hardly causes the rejection of cell；3. the signal path that this product is activated is a known distinctive signal path of nervous system；4. this product can effectively change the activity and state of neuron；5. the essence of this product is one section of amino acid sequence, is easy to degraded, the load without causing organ.
While several treatment choices exist for cervical cancer, such as surgical therapy, chemotherapy, and radiotherapy, some patients will still show poor prognosis. HPV infection is a principal factor for cervical cancer development, from early inflammation to proliferation, angiogenesis, and neoplastic growth. While HPV T-cell responses exist, the tumor seems to evade the immune system upon its tolerance. The latter suggests the existence of a confluent tumor microenvironment responsible for the evasion tactics employed by the neoplasm. Therefore, novel biomarkers governing prognosis and treatment planning must be developed, with several studies tackling the significance of the tumor microenvironment in the genesis, development, proliferation, and overall response of cervical cancer during neoplastic processes. This review aims to analyze and contemplate the characteristics of the tumor microenvironment and its role in prognosis, progression, evasion, and invasion, including therapeutic outcome and overall survival.
Fan Masque is a unique cosmetic paint formula. It is comprised of ingredients found in expensive spa facials that treat the skin, yet is formulated to look like paint, in bright sports team inspired colors. Fan Masque was specifically formulated to solve a the problem that my daughter and other young college women experienced. They could not fully engaging in super fan activities at events such as football games, because traditional face paints often cause skin breakouts and irritation. Fan Masque was designed to function as a face paint and facial all in one, made from only natural and organic ingredients. I experimented for months to find the right ingredients and proportions that make Fan Masque water resistant so it will not run in the rain, yet wash off easily with soap and water. It also contains a natural sunscreen which you do not find in traditional face paints or in spa treatment masks. Fan Mask is the first of a new product category thus needs patent protection for its novelty of use. It goes beyond being a face paint, that won't harm your skin, to one that actually benefits it. Every ingredient was carefully chosen for their already proven benefits to the skin.
On the basis of experimental studies that bone marrow mononuclear cells (BMCs) transfer in the injured tissue can promote regional myocardial perfusion and improved cardiac function, several clinical trials have shown that intracoronary bone marrow mononuclear cell (BMC) transplantation in acute myocardial infarction (AMI) patients several days after myocardial reperfusion is safe and may enhance the improvement of left ventricular ejection fraction (LVEF). The timing of BMC administration, baseline LVEF, dosage of BMC and other factors has been linked to improvement in LVEF after BMC transplantation. In our previous work, we gave BMCs within 24 hours after emergency percutaneous coronary intervention (PCI) and found that it was safe and effective . In addition, there are another report about longer time from symptom onset to BMC infusion (2-4 weeks), which also appeared effective . The timing of intracoronary stem cell administration may have a critical effect on cell engraftment and may be responsible for the various biological and functional responses to therapy. However, few studies have directly addressed the optimal timing of cell injections. Therefore, in this prospective randomized study, BMCs were given at different times (within 24 hours, 3 to 7 days, or 7 to 30 days after reperfusion) to investigate whether the timing of therapy affects the therapeutic response of AMI patients.
The present application relates to the field of immunotherapy, more particularly to the field of adoptive cell therapy (ACT). Here, NKG2D CAR expressing cells that also express IL-18 are proposed. Also proposed are polynucleotides, vectors encoding the NKG2D CAR and IL-18 and cells expressing both. These cells are particularly suitable for use in immunotherapy, including allogeneic therapy. The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. Further, strategies to treat diseases such as cancer using these cells are also provided. The engineered immune cells, such as T-cells or natural killer (NK) cells, expressing such CARs are suitable for treating lymphomas, multiple myeloma and leukemia, but other tumors can be treated as well, depending on the specificity of the CAR. Most notably, as expression and secretion of the pro-inflammatory cytokine I L-18 is beneficial to reducing the immunosuppressive effect of the tumor microenvironment, treatment of solid tumors is envisaged.