anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Surgical site infections (SSIs) are among the most frequently encountered complications in prosthetic surgery, and are associated with increased hospitalization, costs and in-hospital mortality. There is no national system for the comprehensive monitoring of the incidence of SSIs.
METHODS: All patients undergoing orthopedic prosthetic surgery from April 1 to June 30, 2023 were enrolled. Clinical evaluation of the surgical site was conducted at 30 days, and a follow-up telephone interview was carried out by means of a specially designed questionnaire at 90 days.
RESULTS: A total of 59 patients were included. Surgery was performed on the knee in 71.19% and on the hip in 28.81%. The patients' mean BMI was 28.25 ± 2.97, and their mean ASA score was 2.67 ± 0.58. Six patients had diabetes mellitus. The incidence of SSIs was 5.08%; two infections occurred in knee prosthesis surgery and one in hip surgery. Analysis of the data revealed that diabetes was the main risk factor for the development of infection.
CONCLUSIONS: Although based on a small number of patients, these results are encouraging, especially considering that the patients had an average ASA score of more than 2 and a high BMI. However, to further reduce the risk of infection, improved hygiene measures have now been implemented in the operating room and the antibiotic prophylaxis protocol has been updated to take into account the potential for MRSA colonization.
Fosrenol BAY77-1931 chewable tablet in Period 1 and Fosrenol BAY 77-1931 ODT 500 mg in Period 2. The washout interval between period 1 and 2 will be at least 14 days.
The objective of this study is to evaluate narcotic use after implementation of a Non-Opioid Multimodal Pain (NOMO) protocol in patients who are undergoing a urogynecologic procedure. NOMO protocols seek to reduce the opioid usage for patients in the postoperative period. Patients will receive multiple pain medications (usually referred to as a "pain cocktail") that work on various pain receptors throughout the body. These medications are approved for pain control; but they have few side effects and less addictive properties. The study will also evaluate secondary outcomes, including: post-operative pain rating, length of hospital stay, postoperative antiemetic use, bladder catheterization at discharge, number of post-operative phone calls, and rate of reported side effects of opioid use (nausea/constipation). Study participants will be asked to utilize the validated Brief Pain Inventory (appendix A) scale to assess post-operative pain levels. Based on inpatient post-operative opioid use and number of opioid pills prescribed at discharge, an attempt will be made to develop an algorithm for recommended opioid prescribing patterns.
A method and system are described for gathering information about an object including single domain particles. Such single domain particle have a diameter in the range of about 5 nm to 80 nm. The method for gathering information comprises generation of a static magnetic field of less than about 0.1 Tesla applied to the object and generation of an RF energy, pulsed or continous wave, at a frequency so as to generate electron paramagnetic resonance of the single domain particles. The method also comprises detecting the electron paramagnetic resonance of the single domain particles in the form of an image of the object. Alternatively, the single domain particles may have a predetermined diameter and a predetermined saturation magnetization and the applied magnetic field may be such that the single domain particles reach a magnetization being at least 10% of the saturation magnetization, advantageously more. In other embodiments, the principles of the invention are used for detecting tags in an object and for activating tags.
The present invention relates to a use of a restorative herb medicine prepared by adding Silk of Zea mays Linne and Cucurbita moschata. More specifically, the present invention relates to a pharmaceutical composition and health functional food for preventing or treating/ameliorating thrombosis through strong blood coagulation enzyme/factor inhibiting activity and platelet aggregation inhibiting activity by adding Silk of Zea mays Linne and Cucurbita moschata to an existing restorative herb medicine comprising Rehmannia glutinosa var. purpurea, Poria cocos, ginseng and honey as main ingredients. As being proved through an embodiment of the present specification, a restorative herb medicine having a Silk of Zea mays Linne and Cucurbita moschata as an active ingredient of a pharmaceutical composition and health functional food of the present invention: has excellent appealability by adding Silk of Zea mays Linne and Cucurbita moschata; exhibits strong antithrombotic activity by inhibiting thrombogenesis-related enzymes and blood coagulation factors; does not show hemolytic activity to human red blood cells at all; has excellent thermal stability; and does not exhibit loss in effects of inhibiting the thrombogenesis-related enzymes and the blood coagulation factors even at an acidic condition of pH 2 and within blood plasma at the same time such that the present invention is expected to be used for prevention and treatment of thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation. In addition, the active ingredient is processed into various forms such as extract, powder, pill, tablet, and the like to be taken at any time. Accordingly, the present invention is extremely useful in pharmaceutical and food industries.
Patients receive CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope plasmid DNA vaccine with rhuGM-CSF as 3 injections ID every 28 days for 3 months. Patients may also receive 2 additional booster STEMVAC vaccines at 3 and 9 months after the third vaccine in the absence of unacceptable toxicity or disease progression.
The term "catatonia" was introduced by German psychiatrist Karl Kahlbaum in 1874. Although historically tied to schizophrenia, catatonia exhibits a diverse range of phenotypes and has been observed in various medical and neuropsychiatric conditions. Its intrinsic movement characteristics and association with hypokinetic and hyperkinetic phenomenologies place catatonia within the purview of movement disorders. Despite the presence of catatonia in psychiatry literature for over 150 years, many gaps and controversies persist regarding its etiopathogenesis, phenomenology, diagnostic criteria, and treatment. The current versions of the International Classification of Diseases (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) require clinicians to identify any three signs of 15 (ICD-11) or 12 (DSM-5) for the diagnosis of catatonia. Catalepsy and waxy flexibility are the only motor features with high specificity for the diagnosis. We highlight the gaps and controversies in catatonia as a movement disorder, emphasize the lack of a clear definition, and discuss the inconsistencies in the description of various catatonic signs. We propose the exploration of a bi-axial classification framework similar to that used for dystonia and tremor to encourage the evaluation of underlying etiologies and to guide therapeutic decisions to improve the outcome of these patients. © 2024 International Parkinson and Movement Disorder Society.
This study is a non-interventional, multicentre observational study to be conducted at 1000 sites in India. The study targets to enrol approx. 50000 patients with approx. 50 patients per site. The study would enrol Diabetes Mellitus patients who provides written informed consent. No study medication will be prescribed or administered as a part of study procedure. Patients, who have been treated as per Investigators' routine clinical practice will be screened for enrolment in study. The study will be initiated after obtaining written approval of Independent Ethics Committee (IEC) /Institutional Review Board (IRB).

This is a single visit cross sectional study however during site feasibility visit, probability of follow-up of these patients will be evaluated. If feasible protocol will be amended to continue data collection prospectively for appropriate duration
Thiazide-containing combination products are not recommended in patients with severe renal dysfunction. Sudden and potentially life-threatening anaphylactoid reactions have been reported in some patients dialyzed with high-flux membranes (e.g., AN69®*) and treated concomitantly with an ACE inhibitor. In such patients, dialysis must be stopped immediately, and aggressive therapy for anaphylactoid reactions must be initiated. Symptoms have not been relieved by antihistamines in these situations. In these patients, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption.
OBJECTIVE: This systematic review aims to evaluate the effect of yoga interventions on spine and shoulder mobility.
METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and adhered to the methodological framework recommended by the Cochrane Collaboration for the systematic review. An exhaustive search in PubMed, Science Direct, Cochrane Library, and Google Scholar was conducted. The search spanned from inception to May 2023. We included 8 studies in the review, consisting of 5 randomized controlled trials (RCTs), 2 quasi-experimental studies, and 1 study with unspecified design. The study populations included individuals with chronic low back pain, healthy adults, and older adults. The sample sizes of the selected studies ranged from 23 to 120 participants, with an average sample size of 59.
RESULT: The study revealed that yoga interventions have the potential to improve spinal flexibility and increase spine mobility in individuals with chronic low back pain. However, the observed effects differed depending on the specific population and type of yoga intervention. Limited evidence was available regarding the effect of yoga on shoulder mobility, though some studies suggested that yoga may lead to improved shoulder flexion.
CONCLUSION: The review advocates the integration of yoga into clinical practice, rehabilitation programs, and public health initiatives to promote mobility and prevent musculoskeletal disorders. Further research is needed to strengthen the evidence and maximize yoga's potential benefits.
Patients undergo a biopsy during prestudy and after the second course of treatment. Patients receive endostatin IV daily for 4 weeks. Patients on dose level 1-6 receive endostatin over 20 minutes. Patients on dose level 7 receive endostatin over 40 minutes, with no treatment on day 2 of the first course only. Treatment continues every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of endostatin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose limiting toxicity.
BACKGROUND: Brain death has been used to decide whether to keep sustained care and treatment. It can facilitate tissue, organ, and body donation for several purposes, such as transplantation and medical education and research. In Japan, brain death has strict diagnostic criteria and family consent is crucial, but it has been a challenging concept for the public since its introduction, including knowledge and communication issues.
OBJECTIVE: We analyzed data across YouTube and Twitter in Japan to uncover actors and assess the quality of brain death communication, providing recommendations to communicate new medical technologies.
METHODS: Using the keyword "" (brain death), we collected recent data from YouTube and Twitter, classifying the data into 5 dimensions: time, individuality (type of users), place, activity, and relations (hyperlinks). We employed a scale to evaluate brain death information quality. We divided YouTube videos into 3 groups and assessed their differences through statistical analysis. We also provided a text-based analysis of brain death-related narratives.
RESULTS: Most videos (20/61, 33%) were uploaded in 2019, while 10,892 tweets peaked between July 3 and 9, 2023, and June 12 and 18, 2023. Videos about brain death were mostly uploaded by citizens (18/61, 27%), followed by media (13/61, 20%) and unknown actors (10/61, 15%). On the other hand, most identified users in a random sample of 100 tweets were citizens (73/100, 73%), and the top 10 retweeted and liked tweets were also mostly authored by citizens (75/100, 75%). No specific information on location was uncovered. Information videos contained guides for accreditation of the National Nursing Exam and religious points of view, while misinformation videos mostly contained promotions by spirituality actors and webtoon artists. Some tweets involved heart transplantation and patient narratives. Most hyperlinks pointed to YouTube and Twitter.
CONCLUSIONS: Brain death has become a common topic in everyday life, with some actors disseminating high-quality information, others disseminating no medical information, and others disseminating misinformation. Recommendations include partnering with interested actors, discussing medical information in detail, and teaching people to recognize pseudoscience.
BACKGROUND: Left bundle branch area pacing (LBBAP) requires deep septal lead deployment for left-sided conduction stimulation. Advancing leads toward deep septal positions might add mechanical stress on these leads. Concerns about lead performance and reliability remain an unanswered question.
OBJECTIVE: The purpose of this study was to analyze lead performance and integrity of stylet-driven pacing leads (SDLs) for LBBAP.
METHODS: This study assessed lead fracture rates of SDL in a large single-center cohort of adult LBBAP patients. Fluoroscopic analysis of lead bending angulations at the septal insertion point and in vitro bench testing of lead preconditioning were performed to simulate clinical use conditions. Lead performance was compared between LBBAP and conventional right ventricular apical pacing (RVp) sites.
RESULTS: The study included 325 LBBAP patients (66% male; age 71±15 years). During median follow-up of 18 months, 2 patients (0.6%) experienced conductor fracture between tip housing and ring electrode, whereas no such fractures occurred with RVp patients (n = 149; P = .22). X-ray analysis revealed that high lead bending angulations occurred in 1.3% of the patients. Accelerated bench testing of excessive preconditioned leads showcased a higher probability of early conductor fracture compared to standard preconditioned leads.
CONCLUSION: The incidence of early conductor failure in LBBAP seems higher than with conventional RVp sites. The most vulnerable lead part seems to be the interelectrode space between the tip housing and ring electrode. Excessive angulation and preconditioning might contribute to early fatigue fracture.
EEG-based unimodal method has demonstrated significant success in the detection of driving fatigue. Nonetheless, data from a single modality might be not sufficient to optimize fatigue detection due to incomplete information. To address this limitation and enhance the performance of driving fatigue detection, a novel multimodal architecture combining hybrid electroencephalograph (EEG) and eye tracking data was proposed in this work. Specifically, the EEG and eye tracking data were separately input into encoders, generating two one-dimensional (1D) features. Subsequently, these 1D features were fed into a cross-modal predictive alignment module to improve fusion efficiency and two 1D attention modules to enhance feature representation. Furthermore, the fused features were recognized by a linear classifier. To evaluate the effectiveness of the proposed multimodal method, comprehensive validation tasks were conducted, including intra-session, cross-session, and cross-subject evaluations. In the intra-session task, the proposed architecture achieves an exceptional average accuracy of 99.93%. Moreover, in the cross-session task, our method demonstrates an average accuracy of 88.67%, surpassing the performance of EEG-only approach by 8.52%, eye tracking-only method by 5.92%, multimodal deep canonical correlation analysis (DCCA) technique by 0.42%, and multimodal deep generalized canonical correlation analysis (DGCCA) approach by 0.84%. Similarly, in the cross-subject task, the proposed approach achieves an average accuracy of 78.19%, outperforming EEG-only method by 5.87%, eye tracking-only approach by 4.21%, DCCA method by 0.55%, and DGCCA approach by 0.44%. The experimental results conclusively illustrate the superior effectiveness of the proposed method compared to both single modality approaches and canonical correlation analysis-based multimodal methods.
BACKGROUND AND PURPOSE: Patients exhibiting acute dizziness or vertigo often represent a diagnostic challenge, and many undergo neuroimaging for stroke detection. We aimed to demonstrate the imaging outcomes of first-line emergency MR imaging among patients with acute dizziness or vertigo and to determine the clinical risk factors for stroke and other acute pathology.
MATERIALS AND METHODS: This retrospective study included consecutive patients with acute dizziness or vertigo referred for emergency MR imaging in a tertiary hospital during 5 years. We recorded and analyzed patient characteristics, relevant clinical information, and imaging outcomes. Risk score models were derived to predict which patients were more likely to present with positive MR imaging findings.
RESULTS: A total of 1169 patients were included. Acute stroke was found in 17%; other clinically significant pathology, in 8% of patients. In 75% of the patients, emergency MR imaging showed no significant abnormalities. Risk factors for acute stroke included older age, male sex, and a prevalence of cardiovascular risk factors and neurologic signs. Isolated dizziness had no discriminative power on imaging outcomes, and 14% of these patients showed acute stroke. Risk scores had only moderate performance in predicting acute ischemic stroke (receiver operating characteristic area under curve = 0.75) or any significant pathology (receiver operating characteristic area under curve = 0.70).
CONCLUSIONS: Acute dizziness and vertigo remain challenging even when emergency MR imaging is readily available. One in 4 patients had acute pathology on MR imaging. Predictors for acute pathology (older age, male sex, cardiovascular risk factors, and neurologic signs) may aid in patient selection for MR imaging, optimizing the yield and clinical impact of emergency neuroimaging. Low diagnostic yields of CT and internal acoustic canal MR imaging may offer an opportunity to reduce health care expenditures in the future.
1463327 Isolating conalbumin &c. from biological materials OFFICINA TEREPEUTICA ITALIANA OTI LABORATORIO BIOLOGICO SpA 22 Oct 1974 [31 Oct 1973] 45750/74 Heading C3H A method of isolating a transferrine, particularly conalbumin, from biological material containing recoverable transferrine, involves passing the biological material in fluid condition at a pH between 3 and 6 through a solid carrier containing chelating groups coordinated to metal ions (iron, copper &c.) in the presence of a buffer solution at a pH between 3 and 6 which is free of chelating properties, and then eluting the resulting transferrine-metal complex from the solid carrier and recovering pure transferrine in a conventional fashion. An acetate buffer solution of molarity between 0À01 and 0À2 M is used in adsorbing the transferrine on the carrier. For the elution of the transferrine complex produced, either a buffer solution having a pH between 6 and 11, or a buffer solution of pH between 3 and 6 containing chelating groups (sodium citrate) at a concentration of 10<SP>-3</SP> M or higher, is suitable. The biological material is first deionized by treatment with a mixture of anionic and cationic resins. Compounds having chelating properties of M.W. lower than 10,000 i.e. lower than that of transferrine, may be removed by dialysis. The examples are directed to the isolation of conalbumin from egg white using a ferric-carboxymethyl cellulose carrier.
PURPOSE:To obtain the titled remedy containing flavoxate hydrochloride as an active ingredient. CONSTITUTION:A remedy for pollakiuria and residual urine feeling, having a rapid dissolving part consisting of ingredients of 100pts.wt. flavoxate hydrochloride, 0-2,700pts.wt. excipient, 0-270pts.wt. binder and 0-800pts.wt. coating agent and delayed dissolving part consisting of ingredients of 100pts.wt. flavoxate hydrochloride, 0-3,800pts.wt. excipient, 0-380pts.wt. binder, 2-750pts. wt. coating agent and 0-150pts.wt. plasticizer and obtained by blending the rapid dissolving part with the delayed dissolving part at 1:0.5-5wt. ratio based on the flavoxate hydrochloride. The above-mentioned remedy is prepared by granulating and blending the afore-mentioned ingredients using a centrifugal fluidized type coating granulator or extrusion granulator. The dose thereof is 0.5-3g/adult/time and administered twice a day, in the morning and evening. The drug effect duration time is prolonged and administration twice a day is sufficient with high general purpose properties.
A novel wound electrode assembly for a lithium oxyhalide electrochemical cell is described. The electrode assembly comprises an elongate cathode of an electrochemically non-active but electrically conductive carbonaceous material disposed between an inner elongate portion and an outer elongate portion of a unitary lithium anode. That way, lithium faces the entire length of the opposed major sides of the cathode. This inner anode portion/cathode/outer anode portion configuration is rolled into a wound-shaped electrode assembly that is housed inside a cylindrically-shaped casing. A cylindrically-shaped sheet-type spring centered in the electrode assembly presses outwardly to limit axial movement of the electrode assembly. In one embodiment, all the non-active components, except for the cathode current collector which is nickel, are made of stainless-steel. This provides the cell with a low magnetic signature without adversely affecting the cell's high-rate capability.
BACKGROUND: Descemet membrane endothelial keratoplasty (DMEK) has become the dominant keratoplasty procedure. However, the impact of high intraocular pressure (IOP) on the DMEK prognosis in patients without preexisting glaucoma remains unknown.
METHODS: Non-glaucoma patients who underwent DMEK in Peking University Third Hospital between July 2017 and March 2023 with a follow-up duration longer than six months were included in this cohort study. Eyes were divided into three groups: Group A) normal IOP; Group B) early IOP elevation (IOP ≥ 30 mmHg or increase of more than 10 mmHg from baseline within 3 days); Group C) intermediate-term IOP elevation (IOP > 21 mmHg or increase of more than 10 mmHg from baseline after 14 days postoperatively). The postoperative IOP, endothelial cell density (ECD), central corneal thickness (CCT), best-corrected visual acuity (BCVA) and rate of graft failure were analysed.
RESULTS: Forty-seven eyes from forty-seven patients were included. Thirty-seven eyes were bullous keratopathy, and ten were Fuchs endothelial corneal dystrophy. Twenty-five eyes were classified as Group A, six as Group B and sixteen as Group C. The mean peak IOP was 49.00 ± 4.99 mmHg in Group B eyes and 31.89 ± 11.75 mmHg in Group C eyes. The postoperative BCVA significantly differed from that before surgery (P < 0.001). The ECD at 3 months after surgery in eyes with intermediate-term IOP elevation was lower (P = 0.032). Four eyes with intermediate-term IOP elevation developed graft failure (P = 0.001).
CONCLUSIONS: Intermediate-term IOP elevation after DMEK may reduce the graft ECD and lead to graft failure within six months after surgery. However, early IOP elevation had no effect on the prognosis. Careful IOP monitoring and intermediate-term IOP management should be conducted for graft protection.