anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Rheumatoid arthritis (RA) is a chronic inﬂammatory autoimmune disease with systemic manifestations targeting primarily synovial joints and periarticular tissues, with a 1-3% prevalence, it is the most prevalent form of inflammatory arthritis.(1,2) Although synovitis is the pathological hallmark of RA, numerous extra-articular symptoms and comorbidities are probably present.(3) Cardiovascular and pulmonary system diseases are the two main causes of death in RA patients, and their symptoms are the most serious.(2,3) Patients with RA have a 50% greater risk of CV mortality and a two-fold increased risk of myocardial infarction, which is the most common cause of death in this population. (4) Echocardiographic examination is considered a good predictive tool for some cardiac conditions with early findings while no clinical signs is yet found on these patients. (5) The second major cause of death in patients with RA is respiratory disease, which occurs in 30-40% of patients.(6) Sometimes the disease is silent until it has lung complications, which come before joint problems. RA may affect the lung interstitium, airways, and pleurae, while pulmonary vascular involvement is less frequent.(7) Diaphragmatic ultrasound can be used to determine the prevalence of interstitial lung disease involvement in RA as a restrictive disorder. The association between pulmonary function tests (PFTs), potential risk factors, and clinical correlation must be calculated.(8)(9) Anterior chest wall (ACW ) joints undergo joint changes and can be involved along the course of RA yet seems to be underestimated(1) Ultrasonography of ACW can detect those changes even before being clinically evident (10)
Disclosed is a stabilized substrate composition for smoking articles, particularly cigarettes. In general, the stabilized substrate composition comprises an admixture of a binder and an aerosol forming material which plasticizes the binder, together with optional fillers and/or base materials. In the stabilized substrate compositions of the present invention the relative amounts of binder and aerosol former depend particularly on the situation in which the substrate composition is used. In general, the ratio of aerosol former to binder is between about 3:1 and about 40:1. When the stabilized composition is used on a base material such as tobacco cut filler, the ratio of aerosol former to binder should be at least about 15:1, and preferably is from about 25-35:1, with a maximum ratio of about 40:1. If the composition is formed into a cast sheet, the minimum ratio is about 3:1, the preferred ratio is about 8:1, and the maximum ratio is about 10:1. When the stabilized mixture is printed on a sheet or web substrate, the ratio of aerosol former to binder is generally about 6:1, the maximum ratio is about 10:1, and the minimum ratio is about 3:1.
After deciding on the participant of the intervention group the researcher will start the protocol of intervention The researcher will soak a 4×4 cm sterile gauze pad with 0.2 ml equivalent to 2 drops of 10% Lavender essential oil and will suspend the soaked gauze at a distance of 10cm from the patient's nose with the help of forceps, and he or she will have asked to inhale its scent for 5 min. 15 and 40 minutes after the beginning of the aromatherapy treatment, the researcher will measure the nausea and vomiting scores by using the standardized tool. During this entire 40 minutes, the researcher will strictly monitor the participant's condition. If the nausea score is still higher than 1 or the vomiting persists the participants will be noted as failure of treatment and move to standard care.
The invention relates to a hydrophobic drug containing polyelectrolyte complex, its preparation method and an application thereof. The polyelectrolyte complex is formed by static compounding of polycation and electronegative nanoparticles formed by polyanion or its derivative entrapment or linkage of a hydrophobic drug. The particle size of the polyelectrolyte complex is 20-500 nm. The positive/negative charge ratio of the polycation to the polyanion is between 1.2 and 6.0. According to the drug-containing complex formed by static compounding, an external positive charge shell can protect stability of the complex in a gastric acidic environment, and in an intestinal alkaline environment, the complex disintegrates and releases the internal anion drug loaded nanoparticles so as to promote absorption of the drug through intestinal mucosa. In addition, the polycation shell has mucosa adhesiveness and retention time of the drug in gastrointestinal mucosa can be prolonged. Therefore, the complex is suitable for oral administration of hydrophobic drugs. Bioavailability of the hydrophobic drugs is increased, and pains caused by injection delivery can be minimized for patients.
PURPOSE:A feed additive or feed, consisting of at least asaccharide ester of a fatty acid and a salt of a fatty acid, and having improved effects on the promotion of growth, improvement in feed efficiency and maintenance of health of animals, e.g. domestic animals, fowls and fishes. CONSTITUTION:A feed additive or feed, e.g. a crude reaction product containing at least a saccharide ester of a fatty acid and a salt of the fatty acid, and obtained by the alcoholysis of a saccharide with a lower alkyl ester of the fatty acid or glyceride of the fatty acid in the presence of a basic catalyst, containing at least an ester of the saccharide, e.g. sucrose, raffinose or maltotriose, with an about 6-24C fatty acid and a salt of the 6-24C fatty acid, e.g. alkali metallic salt or basic amino acid salt, at a weight ratio of (97:3)-(3:97), preferably (95:5)-(5:95).
A new class of antibiotics effective against methicillin-resistant  Staphylococcus aureus  (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding proteins and/or other important cellular targets. Methods for inhibiting the growth and/or replication of bacteria using the compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, including drug-resistant strains of  Staphylococcus aureus.
The present invention relates to a traditional Chinese medicine preparation for treating habitual abortion, which takes more than 10 Chinese herbal medicines of cornu cervi degelatinatum, barbary wolfberry fruit, south dodder seed and astragalus etc. as the raw materials. The present invention has the effects of tonifying the spleen and the kidney, benefiting qi and securing fetus. The present invention is developed based on the differential treatment of the traditional Chinese medicine, which is also combined with the latest scientific research results. The present invention aims at providing the traditional Chinese medicine preparation to treat habitual abortion. The present invention is characterized by accurate efficacy, safety, reliability, no toxicity or side effects and low price.
The investigators conducted an analytical prospective observational and comparative study between March 2022 and May 2022. The investigators included all patients proposed for elective surgery under general anesthesia with Tracheal intubation other than ENT surgery, ages 18 to 70 years, consenting, classified ASA class I, II, or III, with no history of difficult intubation and/or ventilation, divided into two groups that differ by neostigmine use: group A: systematic decurarization, group B: extubation through clinical criteria. Ultrasound assessments of the vocal cords were performed at 3 different time points: before induction (T0), after extubation (T1), in SSPI 30 minutes after extubation (T2). The investigators have defined H0, H1 and H2, the maximum amplitudes of the vocal cords measured respectively at T0, T1 and T2. The primary endpoint was the ultrasound judged vocal cord range of motion with a ratio of pre- to post curarization amplitude defining the HA score, calculated using the following formulas: H0-H1, H0-H2, HAt1=H1/H0, HAt2=H2/H0. The investigators conducted a single then multi-variate analysis.
Community based exercise programme (FaME) FaME includes and extends the OEP. It will comprise one hour PSI delivered group exercise class in a local community centre for a maximum of 15 participants, and two 30 minute home exercise sessions (based on the extended OEP) per week for 24 weeks. Participants will also be advised to walk at least twice per week for up to 30 minutes at a moderate pace.
Our aim is to study the effect of as-needed oral Nicotine Replacement Therapy (NRT) - 2 mg nicotine gum - for smoking cessation in non-daily, or intermittent, smokers (ITS), and to study the process of relapse in ITS, using Ecological Momentary Assessment (EMA). This is a double-blind, randomized, placebo-controlled trial of oral NRT for smoking cessation in ITS. 600 ITS who are interested in quitting will be recruited through multiple channels. Enrollees will be randomized 1:1 to active 2 mg nicotine gum or an inert control gum. Participants will attend 6 sessions with brief behavioral support, with a planned quit day at week 2. Short and long term abstinence will be assessed and biochemically validated. EMA data collection includes two weeks of baseline data on ad lib smoking patterns and 6 weeks of post-quit data. This will capture data on craving, withdrawal, and relapse among ITS, and relate relapse contexts to baseline smoking patterns.
The invention provides a method for the preparation of liposomes by preparing a solution of a lipid component in an organic solvent and initially combining the thus-formed solution with a second component comprising water to form a reservoir of combined material which affords a multiple-dose system. Then a portion of an intimate mixture formed from the combination can be passed under pressure through an orifice to produce an aerosol spray containing liposomes. Generally an active material which is biologically-active and/or useful in the treatment or care of the human or animal body or of plants may be included in the combination. Also provided by the invention is a pack comprising at least a first chamber containing said combination. The first chamber and/or a second chamber includes at least one propellant material, and the pack includes an arrangement for dispensing the combination through an orifice. In a modification the pack comprises at least a first chamber containing a solution of a lipid component in an organic solvent and means to supply an aqueous component to the chamber. In addition, the invention provides a composition for use in preparing a plurality of unit doses comprising liposomes based on a mixture of said lipid and aqueous components.
PURPOSE:To provide the paste composition giving cured products high in strengths and free from stickiness and useful for dental pattern resins by combining a specific urethane (meth)acrylate compound, a specified fatty acid or its derivative, and a photopolymerization initiator. CONSTITUTION:The paste composition comprises 50-85 pts.wt. of an urethane (meth)acrylate compound which has a viscosity of at least 600 centipoises at 60 deg.C and which is liquid at 20 deg.C, 10-50 pts.wt. of a >=16C fatty acid having a melting point of 70-120 deg.C or its derivative, and 0.05-5 pts.wt. (but the total amount of the compounds is 100 pts.wt.) of a photopolymerization initiator, wherein the former two compounds are penetrated into each other to form a continuous net structure. The paste composition can be utilized as a paste composition for dental pattern resins. The fatty acid is preferably a >=16C fatty acid having a melting point of 70-120 deg.C or its amide, especially 12- hydroxystearic acid or erucic acid amide.
Pituitary apoplexy (PA) may be complicated by development of subarachnoid hemorrhage (SAH). We conducted a literature review to evaluate the rate of PA-associated tumor rupture and SAH. We conducted a systematic literature search (PubMed, Web of Science, Medline) for patients with PA-associated SAH and report a case SAH following PA. Suitable articles, case series, and case reports were selected based on predefined criteria following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). We reviewed included publications for clinical, radiological, surgical, and histopathological parameters.We present the case of a patient with PA developing extensive SAH whilst on the MRI who underwent delayed transsphenoidal resection. According to our literature review, we found 55 patients with a median age of 46 years; 18 (32.7%) were female. Factors associated with PA-related SAH were hypertension, diabetes mellitus, prior trauma, anticoagulant, and/or antiplatelet therapy. The most common presenting symptoms included severe headache, nausea and/or vomiting, impaired consciousness, and meningeal irritation. Acute onset was described in almost all patients. Twenty-two of the included patients underwent resection. In patients with available outcome, 45.1% had a favorable outcome, 10 (19.6%) had persisting focal neurological deficits, 7 developed cerebral vasospasms (12.7%), and 18 (35.3%) died. Mortality greatly differed between surgically (9.1%) and non-surgically (44.8%) treated patients. PA-associated SAH is a rare condition developing predominantly in males with previously unknown macroadenomas. Timely surgery often prevents aggravation or development of severe neuro-ophthalmological defects and improves clinical outcome.
BACKGROUND: Evidence has demonstrated that monitoring of the variable, diversity, and joining gene segments (VDJ) rearrangement of the immunoglobulin (Ig) genes in the circulating tumor DNA (ctDNA) is of value in predicting the outcomes of diffuse large B cell lymphoma (DLBCL). In this study, we investigated the role of VDJ rearrangement proportion in ctDNA for predicting DLBCL progression.
METHODS: Patients diagnosed with newly diagnosed DLBCL were included in this study. The VDJ sequences of IgH were detected using next-generation sequencing (NGS) in formalin-fixed paraffin-embedded tissue and/or peripheral blood. The clonotype of the highest proportion in the peripheral blood was defined as the "dominant circulating clonotype," whilst the clonotype of the highest proportion in matched tissue that is detected in peripheral blood was defined as the "dominant tissue-matched clonotype." The decision tree, a machine learning-based methodology, was used to establish a progression-predicting model through a combination of "dominant tissue-matched clonotype" proportion or "dominant circulating clonotype" proportion, and the clinicopathological information, including age, sex, cell of origin, stage, international prognostic index, lactate dehydrogenase, number of extranodal involvements and β2-microglobulin.
RESULTS: A total of 55 patients with eligible sequencing data were used for prognosis analysis, among which 36 patients had matched tissue samples. The concordance rate of "dominant circulating clonotype" and "dominant tissue-matched clonotype" was 19.44% (7/36). The decision tree model showed that the combination of extranodal involvement event and "dominant circulating clonotype" proportion (≥37%) had a clinical value in predicting the prognosis of DLBCL following combined chemotherapy (sensitivity, 0.63; specificity, 0.81; positive prediction value (PPV), 0.59; negative prediction value, 0.83; kappa value, 0.42). Noticeably, the combination of the "dominant tissue-matched clonotype" and extranodal involvement event showed a higher value in predicting the progression (sensitivity, 0.85; specificity, 0.78; PPV, 0.69; kappa value, 0.64).
CONCLUSION: IgH proportion detected in the ctDNA samples traced from tissue samples has a high clinical value in predicting the progression of DLBCL.
BACKGROUND: The purpose of this study was to determine clinically whether the parallel osteotome technique (POST) reduces the incidence of neurosensory disturbances (NSDs) following bilateral sagittal split osteotomy (BSSO), and to corroborate the findings with finite element analysis.
METHODS: The authors conducted a quasiexperimental study of 30 patients requiring BSSO. The sample was divided into two groups: a control group who underwent the conventional osteotomy technique and an experimental group who underwent POST osteotomy. A finite element analysis simulation of the two techniques was also generated for computational analysis. The primary outcome was clinical comparison of subjective and objective measures for NSDs; the secondary outcome was a comparison of stress, strain, and deformation. The osteotomy technique was the exposure studied. Data were analyzed for differences in proportions and means.
RESULTS: Thirty patients (12 female and 18 male patients; age range, 18 to 28 years; mean age, 21.6 years) were recruited for the study, providing 60 sides as a sample. The experimental group had significantly lower subjective scores for NSD at the 3-month ( P = 0.03) and 6-month follow-ups ( P = 0.025). Objective testing revealed a lower incidence of NSDs for the experimental group during postoperative months 3 ( P = 0.07), 6 ( P = 0.007), and 12 ( P = 0.17). The computational analysis also revealed significantly lower stress ( P = 0.007), strain ( P = 0.009), and deformation ( P = 0.04) on the inferior alveolar nerve with the POST osteotomy.
CONCLUSIONS: The incidence of NSDs following BSSO is lower with the POST osteotomy. This technique also induced significantly lower deformational forces on the inferior alveolar nerve when compared with the conventional osteotomy.
OBJECTIVES: Observational data to support delaying elective pediatric thoracic surgery during peak respiratory viral illness season is lacking. This study evaluated whether lung surgery during peak viral season is associated with differences in postoperative outcomes and resource utilization.
METHODS: A retrospective observational cohort study was performed using the Pediatric Health Information System (PHIS). Patients with a congenital lung malformation (CLM) who underwent elective lung resection between 1 January 2016 and 29 February 2020 were included. Respiratory syncytial virus (RSV) incidence was used as a proxy for respiratory viral illness circulation. Monthly hospital-specific RSV incidence was calculated from PHIS data, and peak RSV season was defined by Centers for Disease Control data. Multivariable regression models were built to identify predictors of postoperative mechanical ventilation, which was the main outcome measure, as well as secondary outcomes including 30-day readmission after lung resection, postoperative length of stay (LOS) and hospital billing charges.
RESULTS: Of 1542 CLM patients identified, 344 (22.3%) underwent lung resection during peak RSV season. 38% fewer operations were performed per month during peak RSV season than during off-peak months (p < .001). Children who underwent surgery during peak RSV season did not differ from the off-peak group in terms of age at operation, race, or comorbid conditions (i.e., congenital heart disease, newborn respiratory distress, and preoperative pneumonia). There was no association between hospital-specific RSV incidence at the time of surgery and postoperative mechanical ventilation, postoperative LOS, 30-day readmission rate or hospital billing charges.
DISCUSSION: Performing elective lung surgery in children with CLMs during peak viral season is not associated with adverse surgical outcomes or increased utilization of healthcare resources.
Participants with cHBV received VBR + SOC NrtI for 48 weeks followed by 48 weeks in follow-up. This treatment was used as a reference regimen.
The invention discloses a gel and a preparation method thereof, and relates to the technical field of gel preparation. The composite material comprises the following raw materials in parts by weight: 38-59.5 parts of polyethylene glycol, 24-30 parts of glycerol, 10-30 parts of sodium carboxymethylcellulose and 1.5-2.0 parts of carbomer. The sodium carboxymethyl cellulose is combined with the polyethylene glycol and the glycerol by utilizing the characteristic that the sodium carboxymethyl cellulose can not swell in the polyethylene glycol and the glycerol and can swell rapidly when meeting water, thereby realizing the effect of easy smearing in a normal state, and also having the functions of permanently adhering and isolating a wound surface after swelling in the water. In order to improve the stability of the three substances and avoid the phenomenon of layering caused by viscosity reduction. The carbomer and the three substances are combined, so that the stability of the whole gel product can be improved, and the requirement of long-term stable storage can be met under the specific raw material proportion. The gel provided by the invention is safe and nontoxic.
Participants in this arm will receive the drug CT-868 in a subcutaneous injection form. The dosage is set at up to 1.8 mg, and it will be administered once daily for a total duration of 16 weeks.
Neomycin occasionally causes skin sensitization. 

Ototoxicity (see WARNINGS section) and nephrotoxicity have also been reported. Adverse reactions have occurred with topical use of antibiotic combinations. Exact incidence figures are not available since no denominator of treated patients is available. The reaction occurring most often is allergic sensitization. In one clinical study, using a 20% neomycin patch, neomycin-induced allergic skin reactions occurred in two of 2,175 (0.09%) individuals in the general populaton. In another study the incidence was found to be approximately 1%.

The following local adverse events have been reported with topical corticosteroids, especially under occlusive dressings: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. 

For medical advice about adverse reactions contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact JHP at 1-866-923-2547 or MEDWATCH at 1-800-FDA-1088 (1-800-332-1088) or http://www.fda.gov/medwatch/.
Patients were entered into the trial on steroids in combination with cytotoxic agents as needed. The steroid dose was the lowest dose at which the patient's disease was controlled before the last flare (see eligibility criteria). The patients were randomized to receive either Dapsone or placebo. Treatment was to be started at a dose of 50 mg and increased by 25 mg increments each week once the hemoglobin was shown not to have dropped by more than 2 gm/dl. The target dose was 150 mg and patients who did not respond could be advanced to 200 mg daily. After beginning treatment, a standardized steroid taper was commenced. A standardized steroid taper was suggested with tapering by 10 mg/wk for doses above 40 mg/day or more slowly if warranted. A slower taper thereafter or an every other day dosing schedule would be elected according to the individual investigator's preference. Flares were treated by increasing the dose of steroids - in the case of a mild flare to the last dose preceding the flare, in the case of a moderate flare by 20 mg/day and in the case of a severe flare by 40 mg/day. Tapering was to be resumed once the disease had stabilized. Disease activity was assessed by a simple scoring system for skin, mucosa, and sites involved. Laboratory assessments initially weekly became monthly once the study medication dosage was stabilized.