anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Otosclerosis is a primary osteodystrophy of the otic capsule that causes stapedo-vestibular ankylosis. Its diagnosis is suspected on the basis of clinical and audiometric elements, basically in the presence of conductive hearing loss with a normal eardrum. The CT-scan is an essential examination for the preoperative evaluation of otosclerosis. The aim of our study was to evaluate the use of CT-scanning in predicting the functional outcome of otosclerosis surgery by correlating postoperative audiometric results and preoperative CT findings.
METHODS: We conducted a retrospective study at the ENT Department in association with the Medical Imaging Department of our hospital, over a period of 8 years, from January 2014 to December 2022 and involving 90 patients (104 ears).
RESULTS: The average age of our patients was 40 years with extremes ranging from 22 to 61 years. We noted a sex ratio of 0.38. The preoperative CT-scan showed signs of otosclerosis in 87% of the cases and infra-radiological forms in 13% of the cases. Veillon stage II was the most frequent radiological stage encountered with a percentage of 48%. A good audiometric evolution, defined by a closure of postoperative Air Bone Gap (ABG ≤ 20 dB) and by an improvement of Bone Conduction (BC gain ≥ 0), was recorded in 86 cases (82.7%) for ABG and in 84 cases (80.8%) for BC gain. Scanographic predictive factors of poor postoperative outcome for ABG and BC gain were: advanced stages (Veillon stage III and IV), endosteal effraction, and round window involvement. According to multivariate analysis, only the extent of otosclerotic foci was directly and independently associated with the postoperative audiometric outcome.
CONCLUSION: The CT-scan is an essential examination in the preoperative evaluation of otosclerosis. It allows a positive diagnosis to be made and evaluate the extension of otosclerosis. Moreover, thanks to the analysis of the extent of the otosclerosis foci, mainly by the Veillon classification, the CT-scan allows to predict the postoperative audiometric prognosis.
WAGR syndrome is a rare genetic disorder characterized by Wilms tumor, aniridia, genitourinary anomalies and mental retardation. The syndrome is caused by heterozygous contiguous gene deletions of variable size on chromosome 11, involving a region that encompasses more than 100 genes, many of which have unknown function in humans. In our preliminary studies, we have observed that approximately two-thirds of patients with WAGR syndrome have deletion of the gene which encodes brain-derived neurotrophic factor (BDNF), and that BDNF haploinsufficiency is associated with obesity and with parent reports of hyperphagia and impaired nociception, suggesting that BDNF may play an important role in human energy balance as well as pain sensation. We now propose to conduct a comprehensive clinical phenotype-genotype study on patients with WAGR syndrome and other 11p deletions. We plan to enroll 75 subjects with WAGR syndrome/11p deletions who will undergo evaluations of the following systems: metabolic/endocrine, sensation/nociception, ophthalmologic, audiologic, neurocognitive, renal/genitourinary, oncologic, dental/craniofacial, cardiac, and orthopedic. Genetic testing will be performed on the parents of subjects with WAGR syndrome/11p deletion who choose to participate in order to determine if parental origin of the deletion influences phenotype. We also plan to enroll 75 healthy subjects as body-size matched controls for metabolic studies and 75 patients with isolated aniridia as visually impaired controls for neurocognitive studies. We hypothesize that a more complete understanding of the correlation between phenotype and genotype could lead to improved medical care of these patients through genotype-specific management as well as yield further insight into the physiological role of genes in the 11p region.
OBJECTIVE: Work stress is a serious problem for employees in primary education. This study evaluates the effects of a work stress prevention approach on emotional exhaustion and work stress determinants (job crafting behavior, quantitative and emotional demands, leadership, support, autonomy, team culture and feelings of competence), and the impact of implementation success (management commitment, employee involvement, communication during implementation) on these outcomes.
METHODS: A quasi-experimental study was conducted with an intervention group (4 schools, N=102 employees) and a control group (26 schools, N=656 employees) using questionnaires at baseline (T0), one-year (T1) and two-year (T2) follow-up. Multilevel mixed model analyses were performed to test effects of condition and implementation success on changes in emotional exhaustion and work stress determinants between T0 and T2 in the intervention and control group.
RESULTS: No effect were found for emotional exhaustion. Improvement of quality of leadership between T0 and T2 was significantly larger in the intervention compared to the control group. Additionally, implementation success was associated with a decrease in unnecessary demands and an increase in quality of leadership, team culture and job crafting behavior.
CONCLUSIONS: This study shows no direct effect of the approach on emotional exhaustion, but it does show beneficial effects on quality of leadership. Additionally, results suggest that, when successfully implemented, the approach also has beneficial effects on other work stress determinants (ie, job crafting behavior, unnecessary demands and team culture). Results indicate that - if implemented successfully - the organizational-level intervention has the potential to improve the psychosocial work context.
INTRODUCTION: Venous thromboembolism (VTE) continues to be a major cause of morbidity in trauma. It is unclear whether the type of hemorrhage control procedure (i.e., splenectomy versus angioembolization) is associated with an increased risk of VTE. We hypothesize that hemodynamically stable patients undergoing angioembolization for blunt high-grade splenic injuries have lower rates of VTE compared to those undergoing splenectomy.
METHODS: The American College of Surgeons Trauma Quality Program dataset from 2017 to 2019 was queried to identify all patients with American Association for the Surgery of Trauma grade 3-5 blunt splenic injuries. Outcomes including VTE rates were compared between those who were managed with splenectomy versus angioembolization. Propensity score matching (1:1) was performed adjusting for age, sex, initial vital signs, Injury Severity Score, and splenic injury grade.
RESULTS: The analysis included 4698 matched patients (splenectomy [n = 2349] and angioembolization [n = 2349]). The median (interquartile range) age was 41 (27-58) years and 69% were male. Patients were well matched between groups. Angioembolization was associated with significantly lower VTE than splenectomy (2.2% versus 3.4%, P = 0.010) despite less use of VTE chemoprophylaxis (70% versus 80%, P < 0.001), as well as a relative delay in initiation of chemoprophylaxis (44 h versus 33 h, P < 0.001). Hospital and intensive care unit length of stay and mortality were also significantly lower in the angioembolization group.
CONCLUSIONS: Angioembolization is associated with a significantly lower incidence of VTE than splenectomy. Thus, angioembolization should be considered for initial management of hemodynamically stable patients with high-grade blunt splenic injuries in whom laparotomy is not otherwise indicated.
At TFPB group, the block will be performed by ultrasound guidance after completion of surgery. TFPB will be performed under ultrasonography guidance using a linear 6 to 13 megahertz ultrasound probe by the anesthesiologist. In TFPB group patients will receive 40 ml %0.25 bupivacaine divided into 2 equal doses between transversus abdominis muscle and transversalis fascia bilaterally.
Patients received zoledronic acid 5 mg in 100 ml solution in a 15 minute intravenous (iv) infusion once per year. The peripheral iv infusion was preceded by and followed by a 10 ml normal saline flush of the intravenous line. In addition to study therapy, all participants received 1200 mg elemental calcium and 800 IU of vitamin D daily. Calcium and vitamin D were supplied in a chewable tablet that was to be taken twice daily.
The invention provides a plaster for relieving pain and swelling, belonging to the technical field of plasters for relieving pain and swelling. The plaster is prepared by decocting 42 Chinese medicinal herbs including gastrodia elata, roots of angelicasinensis (oliv) diels and trogopterus dung. According to the relationship between the internal organs and the meridians and theory of treating an internal illness by externally treating the internal organs, the plaster can be pasted on the skin of the diseased part, and the medicines in the plaster can directly take effect on the diseased part. After the plaster is pasted on the skin of the diseased part, the smell of medicines in the plaster can penetrate through the skin and directly reach the meridians to play a role of eliminating pathogen, drawing out pus, strengthening the body resistance, regulating yin and yang and pacifying the five internal organs. The plaster can achieve an exact treatment effect, is beneficial to tonifying the internal organs and has the advantages of overcoming the defects of bitter tastes of oral medicines, the storage of overmuch toxins due to the taking of a large amount of medicines and the dependence on western medicine of patients. The plaster can be pasted on any diseased part with the medicines thereof penetrating through the skin to unblock the acupuncture points of the diseased part instantly and further take the effects of relieving pain and swelling, controlling the duration of pain, dispelling wind, eliminating cold and promoting the circulation of blood to remove stasis in 10-20 minutes.
SARS-CoV-2 respiratory infection is still under study today, mainly because of its long-term effects. This study aims to analyse health status and health-related quality of life (HRQoL) in survivors of coronavirus pneumonia (COVID-19) who have developed pulmonary sequelae. Prospective observational study of patients diagnosed with COVID-19 pneumonia between February and May 2020. Reviews were conducted at 3 and 12 months after hospital discharge. HRQoL was assessed by administration of the SF-36 questionnaire and data related to medical records and physical examination were also collected. In addition, chest X-ray, computed tomography and pulmonary function test were included as additional tests. 305 patients were admitted for COVID-19 pneumonia of which 130 (42.6%) completed follow-up. The mean age of the enrolled group was 55.9 ± 15.9 years. The most prevalent persistent symptoms were dyspnea (37.3%) and asthenia (36.9%). Pulmonary sequelae were detected in 20.8% of participants. The most frequent alteration was ground ground glass opacities (GGO) (88.9%), with mild extension. Fibrotic changes were found in only 2% of cases. When comparing the two groups, at 3 and 12 months of evolution, lower scores in the vitality (VT) and mental health (MH) domains were found only in the group without sequelae. Days of hospitalisation and Charlson index acted as influential factors on HRQoL. Minimal or mild pulmonary sequelae of SARS-CoV-2 do not cause further deterioration of HRQoL. Repeated medical care and pulmonary rehabilitation are effective tools to improve HRQoL.
Patients who will undergo an exercise treatment for the UT. The exercise therapy will focus on stretching exercises for the UT. Exercise therapy will undergo 2 weeks.
Participants will receive sham rPMS at a very low intensity with the coil placed on the dorsal part of the foot. rPMS parameters will be: 40 trains, intermittently (3) seconds on, (19) seconds off, with an intensity at 5% of maximum stimulator output.
Participants first receive Ergocalciferol 50,000 international units (IU)/week for the first 12 weeks. After a 4 week wash-out period, they then receive matching placebo treatment for 12 weeks.
PURPOSE: African Americans have the highest colorectal cancer (CRC) mortality of all racial groups in the USA, which may relate to differences in healthcare access or advanced stage at diagnosis. Recent evidence indicates that differences in tumor characteristics may also underlie disparities in mortality. To highlight recent findings and areas for investigation, we completed the first systematic review of racial disparities in CRC tumor prognostic markers, including clinicopathological markers, microsatellite instability (MSI), oncogene mutations, and novel markers, including cancer stem cells and immune markers.
METHODS: Relevant studies were identified via PubMed, limited to original research published within the last 10 years. Ninety-six articles were identified that compared the prevalence of mortality-related CRC tumor characteristics in African Americans (or other African ancestry populations) to White cases.
RESULTS: Tumors from African ancestry cases are approximately 10% more likely to contain mutations in KRAS, which confer elevated mortality and resistance to epidermal growth factor receptor inhibition. Conversely, African Americans have approximately 50% lower odds for BRAF-mutant tumors, which occur less frequently but have similar effects on mortality and therapeutic resistance. There is less consistent evidence supporting disparities in mutations for other oncogenes, including PIK3CA, TP53, APC, NRAS, HER2, and PTEN, although higher rates of PIK3CA mutations and lower prevalence of MSI status for African ancestry cases are supported by recent evidence. Although emerging evidence suggests that immune markers reflecting anti-tumor immunity in the tumor microenvironment may be lower for African American cases, there is insufficient evidence to evaluate disparities in other novel markers, cancer stem cells, microRNAs, and the consensus molecular subtypes.
CONCLUSION: Higher rates of KRAS-mutant tumors in in African Americans may contribute to disparities in CRC mortality. Additional work is required to understand whether emerging markers, including immune cells, underlie the elevated CRC mortality observed for African Americans.
PURPOSE: To obtain a stable fiber conditioning composition having a pearly luster, useful for washing hair and arranging conditioning, comprising a water- insoluble fiber conditioning agent and a long-chain saturated primary alcohol. CONSTITUTION: This conditioning comprises 0. 3-10wt.% of a water-insoluble fiber conditioning agent (e.g. aminosilicone), 0.5-10wt.% of a long-chain 24-45C saturated primary alcohol or its derivative, 1-35wt.% of a surfactant and 50-98wt.% of an aqueous solvent which may contain an auxiliary, etc. The conditioning can be prepared into a dosage form such as emulsion, suspension, cream, gel or paste and is preferably a liquid hair conditioning shampoo. The conditioning can readily comb hair after washing, lower static electricity and maintain swelling.
A computer-implemented system and method for tracking patient location is provided. A tracker associated with a patient to be tracked is monitored within a hospital. An identifier of a tracker is associated with identification information for the patient. A location of the patient is determined at predetermined times or on a continuous basis based on a location of the tracker. The determined locations are stored with times at which the locations were determined as a location history for the patient. A request for a location of the patient is received and a currently determined location or a most recent location from the history is provided as the location for the patient, in response to the request.
The invention discloses a Chinese medicinal preparation for treating rosacea, and the Chinese medicinal preparation is mainly used for treating the rosacea. The preparation is mainly prepared from 12 grams of root bark of white mulberry, 10 grams of loquat leaf, 15 grams of poria cocos, 12 grams of plantain seed, 15 grams of houttuynia, 12 grams of magnolia bark, figwort root, 18 grams of dwarf lilyturf tuber, 8 grams of pepperweed seed, 10 grams of gypsum, 18 grams of skullcap root, 8 grams of cooked rhubarb, and 12 grams of immature bitter orange. 1 dose of the medicaments is used every day, the medicaments are decocted with water, and the preparation is administrated after dinner. The residue for papule and abscess is decocted again, and the decoction is applied to the affected part. 15 days constitute a treatment course. The Chinese medicinal preparation for treating the rosacea is simple in formula and remarkable in treatment effect, does not have side effect, and is low in cost, convenient to administrate and convenient to popularize and apply.
Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have raised hopes that analgesic treatments could one day be tailored to a patient's phenotype. Such precise treatment would require a profound understanding of the underlying mechanisms of specific pain phenotypes at molecular, cellular, and circuitry levels. Although preclinical pain models have helped in that regard, the lack of a unified assay quantifying detailed mechanical, cold, and heat pain responses on the same scale precludes comparing how analgesic compounds act on different sensory phenotypes. The conflict avoidance assay is promising in that regard, but testing conditions require validation for its use with multiple modalities. In this study, we improve upon the conflict avoidance assay to provide a validated and detailed assessment of all 3 modalities within the same animal, in mice. We first optimized testing conditions to minimize the necessary amount of training and to reduce sex differences in performances. We then tested what range of stimuli produce dynamic stimulus-response relationships for different outcome measures in naive mice. We finally used this assay to show that nerve injury produces modality-specific sex differences in pain behavior. Our improved assay opens new avenues to study the basis of modality-specific abnormalities in pain behavior.
The invention relates to a method for extracting the Glaucine alkaloid, from plant matter which contain in it, more specifically such from the Papaveraceae families. The working method is ecological. It uses “green” diluters, as it includes at least a single extraction with an extracting agent- alkaline water solution and applying microwave radiation on the plant material during the extraction. The method, according to the invention, is also energy saving. It allows for extraction in a short period of time, with low energy and diluter costs, and accomplishes a level of Glaucine extraction- above 99%. The manufactured Glaucine is microbially clean and suitable for inclusion in cosmetics, pharmaceuticals, and food supplements.
The "control" module will contain a brief series of slides with a voice-over. A physical therapist with experience in treating breast cancer patients will demonstrate a series of 4-5 general stretching and toning exercises.
Research Design and Procedures This study will utilize a between group repeated measures design to measure the effects of the learned MBSR intervention over time. MBSR will be the independent variable. Dependent variables include mindfulness, diabetic quality of life and HbA1c. Adolescents with Type 1 diabetes will be randomly assigned to an intervention group or a wait list/control group that will be taught MBSR after all data has been collected. The study will utilize a 2 (experimental versus wait-list control group) by 3 (pretest \[Time 1\], posttest \[Time 2\], and 3 month follow-up \[Time 3\]) to examine within and between group differences overtime on two psychosocial measures including mindfulness and quality of life. The physiological measure understudy, HbA1c, reflects glucose control over the previous three month period and will be measured at Time 1 and Time 3. MBSR training will be provided via an online website and secure data collection site called MySweetMind.org.
PURPOSE:To obtain a cosmetic composition comprising a lotion or cream giving nourishment and dampness and imparting tonus to skin, containing a specific amount of jojoba oil. CONSTITUTION:The objective cosmetic composition contains jojoba oil called as jojoba wax in an amount of 5-15wt.%, especially about 10wt.% to total weight of the composition. Said jojoba oil is liquid wax collected from seed of an evergreen low three 'Simmondsia-californica' growing in Southwestern America or North Mexico. Said cosmetic composition is able to impart gloss or dampness to skin by applying to the surface skin of human body, thus effectively affects as cosmetic. Further, said composition acts as anti-sunburn cream and cures a mild burn due to sunshine, etc. Furthermore, said composition can eliminate or reduce allergy of the skin and to effectively prevent and cure chaps or cracks of skin in winter.
The invention discloses a pharmaceutical composition for treating black disease of sheep and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following medicinal raw materials: Paris polyphylla, adder-wort, patrinia, humifuse euphorbia herb, groundsel, moutan barks, roots of common peony, fevervines, quispualis indica, areca-nuts, pumpkin seeds, herba cepbalanoplosis segeti, flos sophorae, lalang grass rhizome, rumex japonicas, Japanese beauty-berries, artemisia anomala, madders, lignum dalbergiae odoriferae, lilies, astragalus membranaceus, adenophora tetraphylla, cortex lycii radicis, epipremnum pinnata, herpetospermum seeds, radix phytolaccae and spinach beets. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition disclosed by the invention has the functions of removing blood stasis and hemostasis, eliminating water and swelling, soothing the liver and relieving depression and invigorating spleen to promote digestion, treats based on syndrome differentiation from a holistic view, and is relatively strong intargeting. The efficacy can directly reach the focus to effectively control the pathogenetic condition. The composition is remarkable in curative effect and can be used for reducing the prevalence rate and the death rate and improving the cure rate, the survival rate and the like. Moreover, the composition which is prepared from pure natural traditional Chinese medical materials is cheap, safe, effective, free of medicine residues, and can be used for improving the appetite of the sheep and satisfying the nutritional demand while preventing and treating the black disease of sheep.
Design: The trial was a randomized, controlled, multicenter clinical trial. A total of 190 children aged 3-16 years with high myopia were selected and divided into 95 cases in the test group and 95 cases in the control group. The test group was treated with the Eyesing Instrument developed by Suzhou Industrial Park Zoguan Medical Equipment Co. and conventional optometry. The safety and efficacy of the low-energy laser device in the test group were evaluated by comparing the changes in myopia between the two groups during the observation period. Subjects were screened after signing the informed consent form (performed as early as 7 days before the randomization), and the examination used for screening could use the results of eye examinations performed within 1 week at our hospital, and they were enrolled after confirming that they met the inclusion criteria. On the same day, the grouping was done by randomization, and the glasses were prescribed or the glasses were prescribed in combination with the device according to the grouping results. Visits were performed at 30± 14 days, 90± 14 days, 180± 14 days, 270± 14 days, and 365± 14 days