anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nicotine is improving attentional capacity which goes along with an activation of the attentional network in the brain. So far, however, it is unresolved whether nicotine is used for the purpose of self-medication by those nicotine-dependent subjects who suffer from subclinical or clinical attentional deficits which may sustain nicotine addiction. In the present study, we investigate healthy subjects and schizophrenic patients who frequently show very low attentional capacity with functional magnetic resonance imaging (fMRI) and electrophysiology (EEG) during attention-requiring tasks to assess the level of attentional network activity. It is anticipated that low attentional network activity (during baseline condition, after nicotine challenge and after withdrawal) predicts the degree of nicotine dependence including the strength of withdrawal symptoms and relapse rate after smoking cessation. In addition, we expect that functional variations within alpha4beta2 nAch receptor genotype are associated with attentional capacity and -by extension - with nicotine dependence.

Additionally Self-medication of attentional deficits and of increased stress vulnerability may contribute to nicotine-dependence both in schizophrenia patients and healthy subjects. However, very little is known about the effect of nicotine on stress in schizophrenia. In particular social stressors are highly relevant in schizophrenia often resulting in social withdrawal. A factor contributing to the stress-eliciting nature of social interaction is the misidentification of social information during communication with others. The present project aims at an investigation of nicotine effects on such social information processing and its neurophysiological correlates and on social stress responses. Using a 2x2-factorial design effects of nicotine vs. placebo are experimentally investigated in smoking schizophrenia patients in comparison to smoking healthy controls each after an overnight smoking deprivation. Nicotine will be administered by nasal spray delivering a systemic does of 2 mg nicotine. Event-related EEG potentials will be recorded during the presentation of pictures of facial affect and neutral control stimuli to assess social information processing and its neurophysiological correlates. In addition a videotaped semi-standardized conversation skills role-play test will be used as a social stress situation to assess self-reported and non-verbal affective responses.
Participants will receive 5.6 mg/kg U3-1402 (Patritumab Deruxtecan) intravenously on day 1 every 3 weeks. Part Z will enroll an additional 21 participants with HER2+ MBC.
OBJECTIVE: To analyze the correlation between postoperative complications and combined deflection angle classification adduction type (CDAC-ADT) of femoral neck fractures after cannulated screw internal fixation.
METHODS: The clinical data of 121 patients with CDAC-ADT femoral neck fracture admitted between January 2018 and December 2021 and met the selected criteria were retrospectively analyzed. There were 69 males and 52 females, the age ranged from 19 to 79 years (mean, 48.1 years). The causes of injury included 52 cases of traffic accident, 24 cases of falling from height, and 45 cases of fall. The time from injury to operation ranged from 2 to 12 days, with an average of 6.0 days. Among them, there were 18 cases of CDAC-ADT type Ⅰ, 46 cases of type Ⅱ, and 57 cases of type Ⅲ; 6 cases of Garden type Ⅱ, 103 cases of type Ⅲ, and 12 cases of type Ⅳ; and according to the location of the fracture line, there were 26 cases of subcapitate type, 88 cases of transcervical type, and 7 cases of basal type. All patients were treated with cannulated screw internal fixation. The occurrence of complications (including internal fixation failure, fracture nonunion, and osteonecrosis of the femoral head) was recorded, and the correlation between complications and CDAC-ADT typing, Garden typing, and fracture line location were analyzed.
RESULTS: The patients were followed up 8-44 months, with a mean of 24.9 months. There were 10 cases of internal fixation failure, 7 cases of fracture nonunion, and 30 cases of osteonecrosis of the femoral head after operation. Correlation analysis showed that patients' CDAC-ADT typing was significantly correlated with the overall incidence of complication and the incidence of internal fixation failure, fracture nonunion, and osteonecrosis of the femoral head ( P<0.05), and the Pearson coefficient of contingency were 0.435, 0.251, 0.254, and 0.241, respectively. Garden typing did not correlate with the overall incidence of complication and the incidence of internal fixation failure and fracture nonunion ( P>0.05), but correlated with the incidence of osteonecrosis of the femoral head ( P<0.05), and the Pearson coefficient of contingency was 0.251. Fracture line position typing had no correlation with the overall incidence of complication and the incidence of internal fixation failure, fracture nonunion, and osteonecrosis of the femoral head ( P>0.05).
CONCLUSION: CDAC-ADT typing has obvious correlation with postoperative complications of femoral neck fracture and can be used to predict complications of femoral neck fracture.
BACKGROUND: Paediatric cancer and critically ill patients frequently require central venous catheters for prolonged intravenous therapy. The aim of this study is to compare the difficulty of catheter insertion and the morbidity related to this procedure in these two populations and to investigate risk factors for complications.
METHODS: This prospective observational study was conducted at the Hedi Chaker University Hospital in Sfax, Tunisia, from July 2021 to July 2022. We included all patients aged three months to 14 years who required an infraclavicular subclavian vein catheterization. Patients were divided into two groups: Group 1 included children with malignancies; and Group 2 included critically ill paediatric patients. Then, we compared the demographic data, the difficulty of the catheterization procedure, and catheter-related complications. We also investigated risk factors for complications using a logistic regression model. The significance level was P<0.05.
RESULTS: We included 65 infants and children requiring central venous access, 28 of whom suffered from malignancies. The demographic parameters were comparable. However, the time for the procedure and the number of attempts were higher in the malignancy group with P<0.001. Central venous catheter complications were present 46.4% of the time in Group 1 compared to 21.6% in Group 2 (P=0.032). Malignancies were associated with an increased risk of complications (aOR = 2.95; 95%CI: 0.63-13.8).
CONCLUSIONS: This study showed increased difficulty and higher morbidity related to infraclavicular subclavian vein catheterization among infants and children suffering from cancer.
Active Comparator arm : iron chelation Included 32 thalassemia major patients with low serum ferritin (≥500) . They will receive low dose Deferiprone( DFP )on 50 mg/kg/d.
PCT No. PCT/FR95/01691 Sec. 371 Date Jul. 10, 1997 Sec. 102(e) Date Jul. 10, 1997 PCT Filed Dec. 18, 1995 PCT Pub. No. WO96/19567 PCT Pub. Date Jun. 27, 1996A method is disclosed for gene transfer into a culture of primitive stem cells which comprises a prestimulation step of adding a blocking agent to block at least one inhibitor of a cell cycle of said primitive stem cells. The prestimulation is time-limited for a period of less than approximately 36 hours so that said culture of primitive stem cells retains hematopoietic potential.
Interferon Beta-1a (Rebif®) 44 microgram (mcg) subcutaneously 3-times weekly for 24 months. Dose adjustment was done as per Investigator's discretion.
A Chinese patent medicine for curing tristimania and producing method thereof belong to the technical field of Chinese materia medica preparation. The Chinese patent medicine is substantially composed of bupleurum, white paeony root, grassleaf sweelflag rhizome, and cape jasmine fruit, pinellia tuber, turmeric root-tuber, thinleaf milkwort root-bark, silktree albizzia bark, indian buead, zizyphus vulgaris (fried), immature bitter orange, tabasheer, sea-ear shell and gambir plant. The producing method comprises technical steps of weighting, marinating, heating, extracting, decocting, including, condensing, drying, pelletizing and the like according to prescription. The Chinese patent medicine of the invention has effects of liver-soothing and depression-removing, resolving phlegm, quiet nerves and the like, and treats mainly lightly toxic tristimania casued by liver Qi siltation, phlegm-fire confusing mind. The Chinese patent medicine is capable of greatly increasing medication specificity, and compared with other medications for curing similar diseases, the curative effect is largely increased without side effect. Further, the invention has the advantages of specific ingredients, obvious curative effect, and easy implementation of manufacturing method.
The accurate early diagnosis of colorectal cancer significantly relies on the precise segmentation of polyps in medical images. Current convolution-based and transformer-based segmentation methods show promise but still struggle with the varied sizes and shapes of polyps and the often low contrast between polyps and their background. This research introduces an innovative approach to confronting the aforementioned challenges by proposing a Dual-Channel Hybrid Attention Network with Transformer (DHAFormer). Our proposed framework features a multi-scale channel fusion module, which excels at recognizing polyps across a spectrum of sizes and shapes. Additionally, the framework's dual-channel hybrid attention mechanism is innovatively conceived to reduce background interference and improve the foreground representation of polyp features by integrating local and global information. The DHAFormer demonstrates significant improvements in the task of polyp segmentation compared to currently established methodologies.
Research on the effects of selenium nanoparticles (Se-NPs), particularly in Japanese quails, is lacking, especially regarding the potential for DNA damage. Therefore, this study aimed to investigate the impact of administering 0.2 and 0.4 mg/kg of Se-NPs on the growth performance, DNA integrity, and histopathological alterations of the liver, lung, kidney, and heart in quails. A total of 480 one-day-old Japanese quails were divided into three experimental groups as follows: Group 1 served as the control and received only basic feed, while Group 2 and 3 received 0.2 mg/kg and 0.4 mg/kg of Se-NPs via oral gavage. Our results suggested that, birds fed with Se-NPs at both levels significantly (p < .01) reduced feed intake, however, weight gain was significantly (p < .01) increased in quails supplemented with 0.2 mg/kg. Similarly, feed conversion ratio (FCR) was significantly (p < .01) reduced in group supplemented with 0.2 mg/kg Se-NPs. White blood cells increased significantly (P0.01) in 0.4 mg/kg while haemoglobin and red cell distribution width decreased (p < .01) in the same group. Both treatment regimens resulted in DNA damage and histopathological alterations; however, the adverse effects were more prominent in the group receiving the higher dose of 0.4 mg/kg. These findings indicate that the lower dose of 0.2 mg/kg may have beneficial effects on growth. However, the higher dose of 0.4 mg/kg not only negatively impacts growth but also leads to histopathological alterations in major organs of the body and DNA damage as well.
This study is a prospective, single center, randomized, controlled and open clinical trial initiated by the researchers to evaluate the efficacy and safety of Hetrombopag in the treatment of thrombocytopenia caused by chemotherapy in acute myeloid leukemia. The study focuses on acute myeloid leukemia patients aged 18-70 who have completed induction chemotherapy and achieved complete remission, and have received ≤ 1 course of intensive therapy for consolidation. Patients were randomly divided into the treatment group and the control group through the random number table by 1:1. The treatment group received Hetrombopag and platelet transfusion, and the control group did not receive other platelet raising therapy except platelet transfusion. The study used the proportion of subjects with effective treatment during the randomized treatment period as the main efficacy indicator. 72 patients are planned to be enrolled, with treatment group and control group=1:1.
PROBLEM TO BE SOLVED: To obtain the subject medicine having low toxicity, hardly causing adverse effects and safely usable while possessing anti-helicobacter pylori action by including hydroxycinnamic acid or its derivative as an active ingredient. SOLUTION: This medicine contains hydroxycinnamic acid or its derivative as an active ingredient. The hydroxycinnamic acid has three kinds of isomers of 2 hydroxycinnamic acid, 3-hydroxycinnamic acid and 4-hydroxycinnamic acid and all of these isomers can become active ingredients. The hydroxycinnamic acid is preferably derived from propolis. The medicine has preferably 0.01-100 wt.% hydroxycinnamic acid content. A food composition containing the medicine in general foods exhibits prophylaxis of disease or the like caused by infection of Helicobacter pylori or prevention of recurrence thereof and is useful as a food for retaining health of the stomach and intestines.
The invention belongs to the technical field of pharmaceutical chemistry, and relates to a quinazoline derivate with a general formula (I) as well as the preparation method and the application thereof, wherein both R1 and R2 have meanings defined in an instruction. The invention also relates to the preparation method of the derivative. The derivative and inorganic and organic acid or alkali form salt which is acceptable physiologically, and drug combinations containing the derivative. The compound has valuable pharmacological properties and especially plays a role in restraining signal transduction aroused by tyrosine kinase; and particularly, a mutant EGFR (Epidermal Growth Factor Receptor) (L858R/T790M) and HER 2 have higher inhibitory activity. The invention also relates to a method for treating diseases, in particular to diseases characterized in abnormal erbB PTK (protein tyrosine kinase) activity. The general formula (I) is as follows.
BACKGROUND: Bony defects in finger injuries and infections impose high demands on their treatment due to the close anatomic relationships. Ideally, the injuries are entirely treated in emergency care. Due to the mechanism of the accident, contaminated and compromised soft tissues are often present and set limits to single-stage treatment. We present the long-term subjective and functional results after two-stage reconstruction of bony finger joint defect injuries.
PATIENTS AND METHODS: Over a period of 15 years, a total of 40 patients with 43 fingers were treated due to a defect injury in the phalanges. Initially, the finger was stabilised with Kirschner wires after debridement. After consolidation of the soft tissue, the bone was reconstructed in a subsequent operation by interposition of an iliac crest graft. Complications occurred in 9 patients. Twenty-five patients with 27 fingers were followed up for 10.3 years. Range of motion, length of the affected finger, and grip force, each in relation to the contralateral extremity, were recorded. In addition to a subjective assessment of the global result, the daily function was determined by means of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire.
RESULTS: Significant differences compared with the contralateral extremity (p<0.05) were found in length (70 mm; 91.0%) and total mobility of the affected finger (95°; 46.0%), hand span when the thumb was involved (202.5 mm; 93.4%), and power grip when one of the fingers was injured (30 kg; 84.1%). The DASH score was 4.2 points (0-55.8). Subjectively, 88% of patients were satisfied with the treatment outcome.
CONCLUSION: In case of contaminated and compromised soft tissues, the two-stage treatment of bony defect injuries in finger joints by arthrodesis of the joint is a reliable treatment strategy. In the long run, it results in a very satisfactory function of the hand in everyday life although significant differences have been measured compared with the contralateral extremity.
Impaired Liver Function

ANNOVERA is contraindicated in females with acute hepatitis or severe (decompensated) cirrhosis of the liver [see Contraindications (4)]. Discontinue ANNOVERA if jaundice develops. Acute liver test abnormalities may necessitate the discontinuation of ANNOVERA use until the liver tests return to normal and ANNOVERA causation has been excluded. 

Liver Tumors

ANNOVERA is contraindicated in females with benign or malignant liver tumors [see Contraindications (4)]. Hepatic adenomas are associated with CHC use. An estimate of the attributable risk is 3.3 cases/100,000 CHC users. Rupture of hepatic adenomas may cause death through intra-abdominal hemorrhage. 

Studies have shown an increased risk of developing hepatocellular carcinoma in long-term (>8 years) CHC users. The attributable risk of liver cancers in CHC users is less than one case per million users.
Make-up cosmetic composition comprises a liquid continuous fatty phase structured with at least one structuring polymer having a weight average molecular weight of 500-500000 containing at least one moiety comprising at least one polyorganosiloxane group consisting of 1-1000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions.  Make-up cosmetic composition comprises a liquid continuous fatty phase structured with at least one structuring polymer having a weight average molecular weight of 500-500000 containing at least one moiety comprising at least one polyorganosiloxane group consisting of 1-1000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions consisting of ester, amide, sulfonamide, carbamate, thiocarbamate, urea, urethane, thiourea, oxamido, guanidino and/or biguanidino groups. The polymer is solid at room temperature and soluble in the liquid fatty phase at 25-250 degrees C. The liquid fatty phase comprises at least one compound capable of reducing the enthalpy of fusion of the structuring polymer. The composition contains at least one pigment. The liquid fatty phase, the structuring polymer and the compound capable of reducing the enthalpy of fusion of the structuring polymer form a medium.  An Independent claim is also included for use, in a cosmetic composition, of a quantity of compound capable of lowering the enthalpy of fusion and possibly the melting temperature of the polymer to facilitate the application of the composition and to increase the mass and/or gloss of a deposit of the composition.
PURPOSE: Postoperative shivering (POS) is a common and vital complication after anesthesia, which may result in serious consequences and uncomfortable experiences. Acetaminophen has been used to treat fever and mild to moderate pain. However, there is not enough evidence to prove its advantage for POS. This meta-analysis aimed to explore the prophylactic use of acetaminophen as a valid agent for POS.
METHODS: Two researchers independently searched PubMed, the Cochrane Library, and Embase for controlled clinical trials. The meta-analysis of randomized controlled trials (RCTs) was performed by Review Manager.
RESULTS: Nine trials with 856 patients were included in our meta-analysis. Acetaminophen significantly reduced POS compared with placebo (pooled risk ratio [RR]: 0.43, 95% confidence interval [CI]: 0.35-0.52). What is more, not only 15 mg/kg but also 1000 mg intravenous acetaminophen could reduce the incidence of shivering compared with placebo.
CONCLUSION: Our present meta-analysis demonstrates that the intravenous prophylactic infusion of acetaminophen may prevent POS, and the results may provide new evidence to expand the clinical value of acetaminophen in addition to its routine usage.
SG participants will attend six weekly sessions, 90 minutes in length. It will be unstructured. Participants will use this time to talk about current concerns and to receive support and guidance from other group members and the leaders.
EFFORTLESS is an observational, post market, standard of care, Registry to be conducted at approximately 50 centers worldwide in patients requiring an ICD for the treatment of ventricular tachyarrhythmias. Patients included in the registry will have been implanted with the S-ICD system since its CE mark (commercial regulatory approval) and will be followed for up to 60 months. The patients' perception of their therapy will be evaluated using Quality of Life assessments and the Registry will include an exploratory analysis of resource utilization and costs based on measures of clinical outcome such as complication rates, unscheduled hospitalizations and length of stay. The objective will be to enable comparison of costs of the S-ICD system versus a standard transvenous system.

An Extension Phase Sub-Study will extend the EFFORTLESS S-ICD Registry in order to achieve an average of approximately 8 years of follow-up from index procedure. A subgroup of approximately 200 patients will be enrolled at a sub-set of EFFORTLESS sites. The data analysis will focus on long-term S-ICD system-related adverse events, S-ICD replacements and device longevity.
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to gynecology, operative gynecology, obstetrics. Before treatment, the patient is determined: age (A), the number of previous pregnancies (P), the presence of extrauterine pregnancies in the anamnesis (EP), the presence of adhesions in the small pelvis (AD), the level of the β-subunit of human chorionic gonadotoropin in the blood serum (β- HCG), the sides of the indication according to the ultrasound scanning of the pelvic organs (S), the presence/absence of symptoms of acute abdomen (AA). Then, the prognostic coefficients of the effectiveness of the treatment of extrauterine pregnancy are calculated according to the stated formulas: treatment with methotrexate (PCE1), salpingectomy (PCE2) and salmingotomy (PCE3). The values ​​of the predictive coefficients are compared. And if PCE1is simultaneously greater than PCE2and PCE3, then methotrexate treatment is chosen. If PCE2is simultaneously greater than PCE1and PCE3, then salpingectomy is performed. If PCE3is simultaneously greater than PCE1and PCE2, then salpingotomy is performed.EFFECT: invention provides a simplification and increased objectification of the choice of medical benefits in patients with an extrauterine pregnancy between salpingotomy, salpingectomy and treatment with methotrexate by assessing the complex of the most significant data.1 cl, 1 tbl, 3 ex
The invention mainly relates to the field of drug carriers for cancer treatment, in particular to a method for preparing a reduction-responsive nano micelle drug (TPGS) with long circulation in vivo, small toxic and side effects and high chemotherapy efficiency 3350 ‑SS‑DTX&TPGS 3350 -FOL). Docetaxel (DTX) is hydrophobic and unstable in the aqueous phase. TPGS 3350 Is a derivative of vitamin E, which contains PEG 3350. DTX and TPGS Using disulfide bond 3350 Chaining to form TPGS 3350 -SS-DTX copolymer, followed by TPGS with targeting function 3350 And mixing FOL, and preparing the reduction-responsive nano micelle medicine by a thin film hydration method. The nanometer micelle has high stability, and can promote long circulation in vivo. Also has multiple functions of active targeting function, rapid release of intracellular drugs and the like, thereby realizing effective treatment on tumors and lower toxic and side effects.