anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Breast cancer remains the most common cancer diagnosis and second leading cause of cancer death among Canadian women. Close to 70% of breast cancers are hormone-dependent and endocrine therapy is the mainstay treatment (such as tamoxifen, aromatase inhibitors and lutenizing hormone-releasing hormone analogs). Globally, endocrine therapy has led to the greatest benefit for breast cancer patients resulting in compelling reductions in breast cancer recurrence and mortality rates. Tamoxifen and aromatase inhibitors (e.g. letrozole, anastrozole and exemestane) can cause a variable degree of toxicity linked to estrogen deprivation such as: vasomotor symptoms (hot flashes and night sweats), arthralgia/joint stiffness, genitourinary symptoms (vaginal dryness, dysuria, urinary incontinence, recurrent urinary tract infections and pain during sexual intercourse), insomnia, weight gain, mood changes, cognitive dysfunction, fatigue and skin dryness. It is well acknowledged that endocrine therapy side effects can influence treatment adherence, compliance, and persistence. A systematic review of adjuvant endocrine treatment found that 41 to 72% of patients did not take the correct dosage at the prescribed frequency and 31 to 73% discontinued endocrine therapy. Treatment adherence and persistence are key issues in breast cancer, as early cessation or reduced compliance/adherence to hormonal therapy leads to reduced disease-free survival and increased mortality. Despite a plethora of studies aimed at reducing the side effects of endocrine therapy there is no clear evidence that any of them have resulted in improved adherence/compliance/persistence. In practice, it is common to see a clinician reducing dose-intensity or frequency when patients develop intolerable side effects from endocrine therapy, i.e. either using 10 mg instead of 20 mg of Tamoxifen daily, or an every other day schedule for aromatase inhibitors. However, this commonly used practice has not been evaluated in a prospective trial. The researchers propose to conduct the world's first prospective randomized clinical trial to evaluate a dose-frequency escalation strategy of endocrine therapy (meaning taking the dose every other day for 1 month and then daily) and its effects on adherence and tolerability.
BACKGROUND AND AIMS: Dwell time is a critical component of automated peritoneal dialysis (APD) prescription, the stage at which transmembrane mass and fluid transfer occur. Loss of prescribed dwell time (LDT) can negatively influence the efficiency of APD. We investigated the incidence of LDT and related causes using APD in the acute care setting at a tertiary care center.
METHODS: Retrospective analysis was conducted of all inpatients receiving APD treatments from 1 December 2021 to 1 June 2023. Patient demographics, comorbidities, laboratory, and treatment data were extracted from electronic medical records and a propriety database.
RESULTS: N = 235 cycler treatments completed by 32 patients were included for analysis. The total LDT per treatment exceeding 30 minutes and 60 minutes occurred in 27% and 20% of all treatments. LDT of more than 10 minutes per each cycle exchange occurred in 26%. Session disruptions were caused by slow out-flow (55%), inadequate drain volumes (32%), patient line occlusions (20%), and priming errors (23%). The slow flow alarm requiring user intervention was reported to occur in about one-third of all treatments (31%).
CONCLUSION: There was significant LDT and inadequate drain volume seen in about one-quarter and one-third of all inpatient APD treatments respectively. This can impact solute clearance and ultrafiltration.  Slow flow alarms were the most prevalent and the leading cause of LDT followed by inadequate drain volume. Future studies are required to investigate measures to reduce slow drain and improve drain volume in the hospital setting.   .
A method of predicting the responsiveness of a cancer patient to immunotherapy, comprising the following steps. Peripheral blood samples are taken from cancer patients before or after receiving immunotherapy. Detecting the number of immune cells in a peripheral blood sample of a cancer patient. The number of immune cells is compared to the first threshold and/or the second threshold to predict whether the cancer patient will benefit from immunotherapy. The first threshold value and/or the second threshold value is determined by the following steps: a statistical analysis of the correlation between the number of immune cells in a group of cancer patients and the expected risk of disease progression in the group of cancer patients is performed and then statistically significant values are obtained. The values are used to define the correlation.
Group of 45 patients with short-term desire for pregnancy who will undergo laparoscopic ovarian cystectomy with use of indocyanine green. Evaluation of the ovarian reserve preoperatively and longitudinal cohort follow-up after surgery at 6 months and 12 months. Analysis by a new imaging technique.
1,267,564. Polymerizable dental compositions. ESPE FABRIK PHARMAZEUTISCHER PRAPARATE G.m.b.H. 15 May, 1969 [15 May, 1968], No. 24943/69. Heading C3P. Polymerizable compositions for use in making dental fillings and dental replacement parts (e.g. crowns) comprise (a) a diester of the formula wherein R is H or methyl, X is an alkylidene, cycloalkylidene or -SO 2 - group, and Y is an oxyalkylene group having 2-5 carbon atoms, the O atom of which is attached to the benzene ring, or a substituted or unsubstituted alkylidene group having 1-5 carbon atoms, the benzene rings optionally being further substituted and (b) a free radical-forming polymerization catalyst. In use, the composition is polymerized in situ in or on a tooth or tooth replacement part, or is polymerized and simultaneously or subsequently shaped to produce a tooth replacement part. Suitable polymerization catalysts include benzoyl peroxide, lauroyl peroxide, mono-t-butyl monopermaleate, t-butyl hydroperoxide, azoisobutyronitrile, and redox systems. The compositions preferably also include a filler, e.g. polymethyl methacrylate fine beads, glass or quartz fibres, quartz powder, aluminium oxide, calcium phosphate, plaster of Paris and silicates. They may also contain a pigment. In Example 7, hexanediol-1,6-dimethacrylate is used as a comonomer.
Clinical parameters used for hemodynamic assessment and titration of vasopressor therapy in neonates with septic shock have several limitations. Functional echocardiography is an emerging tool for bedside assessment of cardiac function and may be useful for diagnosis of shock and assessing the response to therapy. Data regarding echocardiographic parameters in neonates with shock is lacking. This prospective observational study was conducted in a Level III NICU with the primary objective of comparing echocardiographic characteristics of neonates with septic shock at diagnosis, following fluid boluses, and after maximum inotropic support [A1]. Additionally, we compared these characteristics with those of healthy stable neonates who were gestation and postnatal age-matched. A total of 36 neonates with septic shock and 30 gestation and postnatal age-matched controls were enrolled. The mean (SD) gestation and birth weight of neonates with septic shock were 30.6 (4.0) weeks and 1538 (728) g, respectively. Gram-negative bacilli constituted 78.9% of all isolates. At presentation, there was no significant difference between neonates with shock and controls in terms of ventricular outputs, shortening fraction, ratio of early to late diastolic trans-mitral flow velocity, and myocardial performance indices. The distensibility index of inferior vena cava was higher in neonates with shock compared to controls, (17% vs 10%, (p < 0.01)). Left ventricular output was 209 (92) and 227 (102) ml/kg/min (p = 0.53) and right ventricular output was 427 (203) and 459 (227) ml/kg/min, (p = 0.03), respectively, before and after inotropic therapy.     Conclusion: Echocardiographic parameters may not differentiate neonates with septic shock from hemodynamically stable neonates. Neonates with shock associated with predominantly gram-negative sepsis are not able to augment cardiac functions, either at the onset or after administration of inotropes.      Trial registration: (CTRI/2017/12/010766). What is known: • For neonates with shock, echocardiography is becoming increasingly popular as an objective method of evaluating hemodynamics. • In healthy preterm neonate, cardiac output has been known to increase in response to altered hemodynamics during states of increased oxygen demand. What is new: •  In the setting of septic shock induced by gram-negative organisms, echocardiographic parameters are less likely to assist in the assessment of the response to vasoactive agents. Cytokines, induced by gram-negative organisms, may alter adrenoreceptors in myocardium and vasculature.
Following amputation, SurgX™ will be applied directly to the surgical incision in the operating room under sterile conditions and covered with SOC dressing. The surgical dressing will not be removed until post-operative day 3, except if deemed necessary by the treating surgeon. At that time, direct application of the BlastX™ to the incision will be placed, then covered with a SOC dressing. BlastX™ will be applied every day and covered with SOC dressing.
A relevance system ranks a set of medical studies based on a relevance of each medical study in the set of medical studies to a patient profile. The relevance system includes a relevance model. The relevance model determines a relevance of each medical study to the patient profile based on a semantic relationship score, a concept relationship score, and a term-occurrence score. The semantic relationship score is a measure of a similarity in semantic meaning of a medical study and a patient profile. The concept relationship score is a measure of the closeness of medical concepts in a medical study to medical concepts in a patient profile. The term-occurrence score is a measure of occurrences of terms in a medical study that also appear in a patient profile and the statistical significances of the terms.
FIELD: medicine, phytotherapy, pharmacology. SUBSTANCE: method involves addition of dry or aqueous, or spirituous, or oily, or aqueous-spirituous or spirituous-oily extract, or liquid or dry juice of plants in the amount 0.01-10.0% of active substance mass (as measured for total sum of antioxidants) to drug showing antioxidant activity. Drug with enhanced activity has at least one active substance and active addition. Drug has dry or aqueous, or spirituous, or oily, or aqueous-spirituous, or spirituous-oily extract, or liquid or dry juice of plants showing antioxidant activity taken in the amount corresponding to 0.01-10.0 mas. p. (as measured for sum of antioxidants) per 100 mas. p. of active substance as the active addition. EFFECT: broadened spectrum of agent with enhanced activity. 16 cl, 14 ex
Parallel- and cross-bar techniques are surgical methods used in the pectus excavatum. While the parallel bar is used in many centers, the cross bar is a new technique. The aim of the study is to evaluate the data of centers using cross bar and parallel bar. The aim of this multicenter study is to retrospectively evaluate the data of centers have been using both cross-bar and parallel-bar techniques. 213 parallel bars and 205 cross bars were used. Parallel-bar advantages: the mean patient satisfaction score was 9.40 ± 0.95. Cross-bar advantages: the rate of patients with symmetric deformity was 75.6%, recurrence 0.5%. The mean patient satisfaction score was 9.40 ± 0.95 in operations performed with the parallel-bar technique and 9.13 ± 1.11 in operations performed with the cross-bar technique (p < 0.05). Recurrence was observed in 3.3% of patients undergoing surgery using the parallel-bar technique and 0.5% of patients undergoing surgery using the cross-bar technique (p < 0.04). The cross-bar technique is more advantageous in terms of the recurrence, while second, the parallel-bar technique is associated with greater patient satisfaction. Comparison of data from different countries reveals the differences between patients who have been treated with minimally invasive repair of pectus excavatum and the outcomes of surgery.
PURPOSE:A skin cosmetic obtained by incorporating an oil prepared from seeds of an evening primrose (Oenothera tetraptera Cav.) with other components, having improved feeling of use, and safe for the skin. CONSTITUTION:A skin cosmetic, obtained by incorporating an oil prepared from seeds of an evening primrose (Oenothera tetraptera Cav.) by pressing the seeds according to the well-known method, or further extracting the seeds with a solvent, and subjecting the resultant material to purification steps such as deacidification, deodorization, etc., incorporating the resultant material together with an antioxidant in a skin cosmetic, and having better affinity for the skin than the comentional skin cosmetic containing a vegetable oil, e.g. olive oil, almond oil or safflower oil, and capable of giving oily feeling and moist feeling suitable to the skin without stickiness. The amount of the oil obtained from the seeds of the evening primrose based on the total amount of the above-mentioned cosmetic varies with the kind, etc. of the cosmetic, and the amount is for example up to about 5wt% in skin milk, etc., and up to 60wt% in an anhydrous skin cosmetic, e.g. nourishing oil.
A computerized pain visualization system and method. A web-based application and interface allows individuals to anonymously share information about where they hurt or specific regions of the body that are most worrisome to them. The web-based application comprises a visual interface that supports selection of parts or regions on an image of a human body. The data becomes viewable and filterable by geographic location, age, sex, or a variety of other data sets collected from the anonymous users. In an example embodiment, Users register and sign in at a web site. A selectable body interface is presented and the user is prompted to select one or more pain locations on the virtual body. The user's selections are recorded in a database. Another page of the application presents a search option that facilitates searching and visualizing the data, filterable by users' registration information.
The invention discloses external medicinal liquor for treating gout and a preparation method thereof. The medicinal liquor includes white spirit and traditional Chinese medicines, wherein the traditional Chinese medicines include rhizoma smilacis glabrae, schefflera kwangsiensis, honeysuckle stem, shiny-leaved yellow horn, rhizoma dioscoreae hypoglaucae, giant knot weed, pine nodular branch, Japanese yam, ramulus mori, herba siegesbeckiae, corydalis amabilis, caulis sinomenii, lycopodium clavatum, caulis impatientis, radix rubiae, pawpaw, fructus liquidambaris, radix cyathulae, earthworm, herba aristolochiae, sinapis semina, girald daphne bark, caulis clematidis armandii, radix aconiti preparata, thunder god vine and nux vomica. According to the medicinal liquor disclosed by the invention, all the components in the formula have functions of clearing away heat and toxic materials, and all the medicines coordinate and complement each other, thus enhancing functions of clearing heat, cooling blood and detoxifying; the medicinal liquor is obvious in effect and can take effect quickly. The preparation process is simple and applicable to mass production. The preparation method comprises the following steps: cleaning all the raw materials with water, drying in the sun, adding in liquor, sealing and soaking for 15-30d, and separating out liquor to obtain the medicinal liquor. The medicinal liquor, through the reasonable matching and synergistic effect of all the medicines, can achieve functions of dispelling wind, eliminating dampness, activating blood to remove meridian obstruction, eliminating swelling and relieving pain.
TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that regulates gene expression, and its malfunction in neurons has been causally associated with multiple neurodegenerative disorders. Although progress has been made in understanding the functions of TDP-43 in neurons, little is known about its roles in endothelial cells (ECs), angiogenesis, and vascular function. Using inducible EC-specific TDP-43-KO mice, we showed that TDP-43 is required for sprouting angiogenesis, vascular barrier integrity, and blood vessel stability. Postnatal EC-specific deletion of TDP-43 led to retinal hypovascularization due to defects in vessel sprouting associated with reduced EC proliferation and migration. In mature blood vessels, loss of TDP-43 disrupted the blood-brain barrier and triggered vascular degeneration. These vascular defects were associated with an inflammatory response in the CNS with activation of microglia and astrocytes. Mechanistically, deletion of TDP-43 disrupted the fibronectin matrix around sprouting vessels and reduced β-catenin signaling in ECs. Together, our results indicate that TDP-43 is essential for the formation of a stable and mature vasculature.
Women recruited for the couples group will be asked to invite their husbands to participate, regardless of their husband's CVD status, and men whose wives do not have CVD similarly will be asked to enroll with their wife. The intervention consists in exposing them to bi-monthly educational sessions on diet and exercise. The intervention consists in exposing participants with bi-monthly educational sessions on diet and exercise. Participants will be organized in groups of 15 to 30, led by one community health worker (CHW) assisted by a diabetes peer educator (PE). The basic format for the group sessions will follow the pattern developed with the DPP program, beginning with a discussion of "success" stories from the past weeks before proceeding to the didactic portion of the session. The sessions will mix the didactic portions facilitated by the PE with group discussions, activities and role plays, facilitated by the CHW.
BACKGROUND: In the event of an advanced rectal carcinoma, an evisceration with rectal amputation may become necessary. The resulting defects, due to their extent, depth, or local tissue damage from previous surgeries and radiation, can in many cases only be closed through free microvascular tissue transfer. In this case series, we demonstrate the successful combination of a musculocutaneous musculus vastus lateralis flap (MVL) with a direct connection to the superior gluteal artery.
MATERIALS AND METHODS: Over a 47-month period, we retrospectively examined 11 cases of patients with dorsal pelvic defects after evisceration and rectal amputation that could not be closed using local or regional means. In cases of extensive defects with deep pararectal wound cavities, all these patients underwent defect coverage through a free myocutaneous MVL flap with a direct vascular anastomosis to the superior gluteal vessels.
RESULTS: The mean defect size was 290.0 cm² (SD: 131.2; range: 200-600 cm²). The mean defect depth was 10.5 cm, necessitating MVL flap reconstruction with an average size of 336.3 cm². Three operative revisions were required due to postoperative bleeding. There were no arterial or venous thromboses, and no flap loss occurred. Only one necrosis of a distal flap tip was observed, which could be corrected secondarily by direct suturing. The case-mix evaluation yielded an average value of 24.251 (SD: 21.699; range: 7.036-65.748) points, emphasizing the complexity of the cases.
CONCLUSIONS: Our results indicate that a free microvascular MVL flap is a viable therapeutic option for pararectal defects that cannot be closed by local or regional methods. The superior gluteal artery proves to be a safe and sufficient vascular connection. In combination, even extensive defects can be successfully closed.
Daily consumption of almonds over 16 weeks will produce a decrease in hemoglobin A1c (HbA1c) levels in adults with pre-diabetes.

Lay Summary:

Persons developing type 2 diabetes mellitus (T2DM) will typically first have a condition called pre-diabetes. Lifestyle is a major factor that determines whether pre-diabetes becomes full T2DM. Lifestyle includes dietary habits and physical activity. Many people develop T2DM because of poor dietary habits and a sedentary lifestyle. Moreover, eating a high-fat, high-sugar diet can damage the blood vessels and increase the risk of strokes and heart attacks. A person's diet may produce substances in the blood that can interfere with the production of insulin in the pancreas. Sometimes, these changes in the insulin producing cells are serious and can eventually interfere with how the cells in the body use blood sugar, which causes T2DM. Techniques are available to measure circulating substances in the blood of persons with pre-diabetes that may be associated with the development of T2DM. Laboratory research has shown that almonds contain high levels of important compounds that may influence the onset of heart disease and T2DM. A meal plan that includes almonds daily will be given to half of the study participants and the other participants will be given a meal plan that is "nut-free". Because of the potential to delay the onset of heart disease and T2DM in some persons with pre-diabetes, this 16-week study will collect and analyze blood samples for changes that may make the person with pre-diabetes more likely to develop heart disease and T2DM. Blood samples will be collected at weeks 0, 8 and 16 to measure compounds that may be influenced by consuming almonds daily. This study will also attempt to understand other possible causes of heart disease and T2DM in persons with pre-diabetes; particularly those that might be related to body weight and body composition. Body composition techniques using very small amounts of electrical current are available to study body fat. Body weight, waist and hip measurements, blood pressure and body composition testing will be performed at the start of the study and every 4 weeks during the study. Lastly, these other possible causes of heart disease and T2DM will be investigated to look at relationships with the substances in the blood.
We describe systems and methods for generating and training convolutional neural networks using biological sequences and relevance scores derived from structural, biochemical, population and evolutionary data. The convolutional neural networks take as input biological sequences and additional information and output molecular phenotypes. Biological sequences may include DNA, RNA and protein sequences. Molecular phenotypes may include protein-DNA interactions, protein-RNA interactions, protein-protein interactions, splicing patterns, polyadenylation patterns, and microRNA-RNA interactions, which may be described using numerical, categorical or ordinal attributes. Intermediate layers of the convolutional neural networks are weighted using relevance score sequences, for example, conservation tracks. The resulting molecular phenotype convolutional neural networks may be used in genetic testing, to identify drug targets, to identify patients that respond similarly to a drug, to ascertain health risks, or to connect patients that have similar molecular phenotypes.