anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Periprosthetic femoral fractures (PFFs) are serious complications in hip arthroplasty for femoral neck fractures. The rates of intraoperative (iPFFs) and postoperative PFFs (pPFFs) are higher in cementless stem cases than in cemented cases. This study aimed to investigate the effects of cerclage cabling on PFF prevention in cementless arthroplasty for femoral neck fractures.
METHODS: This retrospective study included 329 consecutive patients who underwent hip arthroplasty using a cementless stem for femoral neck fractures. A total of 159 and 170 patients were in the non-cabling and cabling groups, respectively. Patient characteristics were comparable in both groups. The PFF occurrence (iPFF and pPFF) rates, reoperation rates, operative time, and blood loss volume were compared between the groups.
RESULTS: The iPFF rate was significantly higher in the noncabling group (6.3%) than in the cabling group (0%, P < .001). The rate of pPFF was significantly higher in the non-cabling group (5.1%) than in the cabling group (0.6%; P = .016). All patients in the non-cabling group required reoperation (5.1%), whereas the patient in the cabling group was an ambulatory case and required no reoperation (0%, P = .003). No significant difference in either operative time or blood loss volume was observed between the non-cabling (50 minutes, 133 mL) and cabling (52 minutes, P = .244; 149 mL, P = .212, respectively) groups.
CONCLUSIONS: When a cementless stem is used to treat unstable femoral neck fractures, cerclage cabling effectively prevents iPPF and pPPF without increasing surgical time or blood loss volume.
Patients receive savolitinib PO QD on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT at screening and on study, undergo bone scan as clinically indicated, and undergo collection of plasma and serum samples at screening, on study, and during follow up.
1. Technical Result Increase in assortment of anti-cancer medicinal preparations.           2. Essence A composition of the formula (1)    wherein R1, R2 R3, R4, R5, R6, A, X, Y and m have the values indicated in the description;      method for their preparation comprising a)	spirit conversion of the formula wherein A, Y and R have the values indicated in the description; X represents a leaving group of halogen,  sulfonyl or alkyl, in the appropriate conditions in he composition of the formula (1) or (b) oxidation of the compound of the formula (1), where A is S with production of the appropriate compound of formula (1);  or conversion of the formula (1) in to the pharmaceutically acceptable salt and pharmaceutical compositions containing the same.         3. Field of Application Medicine.
The invention relates to a production technology of a scutellaria baicalensis-dried syinga reticulata var. mandshurica bark-folium rhododendri daurici cough relieving oral solution. The production technology of the scutellaria baicalensis-dried syinga reticulata var. mandshurica bark-folium rhododendri daurici cough relieving oral solution comprises the following steps: extracting volatile oil from folium rhododendri daurici, and storing an aqueous solution after distillation by virtue of another container for later use; adding water into dried syinga reticulata var. mandshurica bark and decocting for three times, filtering, mixing filtrate with folium rhododendri daurici liquor, and concentrating into fluid extract; and slicing up scutellaria baicalensis, adding water and decocting for three times, filtering, mixing filtrates, adding equal quantity of hexyl alcohol, stirring, filtering, mixing filtrate with the folium rhododendri daurici liquor for later use and the fluid extract, regulating pH value to be about 7.5, refrigerating for 72 hours at the temperature of 4-7 DEG C, taking supernate, mixing the supernate with folium rhododendri daurici oil, adding cane sugar, sodium cyclamate and essence, blending, adjusting volume by virtue of water, filtering, performing split charging, sterilizing, and bottling. The production technology of the scutellaria baicalensis-dried syinga reticulata var. mandshurica bark-folium rhododendri daurici cough relieving oral solution has the characteristics that a medicine extraction technology is scientific, the medicines can be furthest utilized, production cost is low and the scutellaria baicalensis-dried syinga reticulata var. mandshurica bark-folium rhododendri daurici cough relieving oral solution is easy to take and is worthy of popularization and application in a pharmaceutical factory.
A hallmark of cancer cells is their remarkable ability to efficiently adapt to favorable and hostile environments. Due to a unique metabolic flexibility, tumor cells can grow even in the absence of extracellular nutrients or in stressful scenarios. To achieve this, cancer cells need large amounts of lipids to build membranes, synthesize lipid-derived molecules, and generate metabolic energy in the absence of other nutrients. Tumor cells potentiate strategies to obtain lipids from other cells, metabolic pathways to synthesize new lipids, and mechanisms for efficient storage, mobilization, and utilization of these lipids. Lipid droplets (LDs) are the organelles that collect and supply lipids in eukaryotes and it is increasingly recognized that the accumulation of LDs is a new hallmark of cancer cells. Furthermore, an active role of LD proteins in processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes of LD-resident proteins (perilipins, lipases, and acyl-CoA synthetases), we provide an overview of the contribution of LDs to cancer progression and discuss the role of LD proteins during the proliferation, invasion, metastasis, apoptosis, and stemness of cancer cells.
A pump includes a reservoir, a port, and a plunger. The reservoir delivers a liquid by discharging the liquid through the port coupled to the reservoir. A piston of the plunger defines a liquid side of the reservoir and a non-liquid side of the reservoir whereby movement of the plunger towards the liquid side of the reservoir discharges liquid through the port. The pump also includes a reference-volume assembly and/or a linear position sensor. The reference-volume assembly is coupled to the reservoir at an opposite end of the reservoir relative to the port and includes a reference-volume chamber in acoustic communication with the non-liquid side of the reservoir, a speaker disposed within the reference-volume chamber, and a reference microphone disposed within the reference-volume chamber. The pump estimate the amount of liquid discharged from the reservoir.
No specific information is available on the treatment of overdose with aripiprazole. An electrocardiogram should be obtained in case of overdosage and if QT interval prolongation is present, cardiac monitoring should be instituted. Otherwise, management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers. 

Charcoal: In the event of an overdose of aripiprazole, an early charcoal administration may be useful in partially preventing the absorption of aripiprazole. Administration of 50 g of activated charcoal, one hour after a single 15 mg oral dose of aripiprazole, decreased the mean AUC and Cmax of aripiprazole by 50%. 

Hemodialysis: Although there is no information on the effect of hemodialysis in treating an overdose with aripiprazole, hemodialysis is unlikely to be useful in overdose management since aripiprazole is highly bound to plasma proteins.
Subarachnoid hemorrhage (SAH) as a worldwide significant cause for morbidity and mortality, especially affecting young population, accounts for 4%-10% of all strokes. About 25% of SAH patients die and 50% left with significant disability, which according to the relative youth of the affected individuals means that this event is responsible for a quarter of all years of life lost as a result of stroke. Cerebral vasospasm, as the most feared complication after SAH leading mostly into ischemia, associated with delayed deterioration, continues to be both a difficult entity to treat and a leading cause of morbidity in patients. A high number of investigators focused on vasospasm research to develop effective therapy strategies to treat this entity, however, results of experimental studies and clinical trials about calcium channel blocker nicardipine and the endothelin-1 antagonist clazosentan as sources of hope in vasospasm treatment did not reveal an improvement in patient outcomes. Recently, there is a renewed interest in looking for other potentially targets for therapy.

Vitamin D, especially the aktive hormone 1,25-dihydroxycholecalciferol (1,25VitD3), has been suggested to limit inflammation, cancer, development of heart failure and myocardial infarction through the nuclear vitamin D receptor (VDR) by balancing the gene expression. Thus, vitamin D deficiency is linked to increased risk in many clinical settings including cardiovascular disease, stroke and critically ill patients. Furthermore, low vitamin D status has been associated with autoimmune disorders such as multiple sclerosis or neoplastic diseases, increased rates of infections and increased mortality. In case of ischemic stroke, a higher rate of vitamin D insufficiency has been suggested in patients associated with poorer outcomes. Nevertheless, these observations still remain controversial.

However, current data attracted considerable attention in neurovascular research to study the effects of this hormone on SAH. Recently, a few experimental and clinical studies have already worked on this topic. A rat model of SAH confirmed that vitamin D pretreatment attenuates cerebral artery remodeling and vasospasm as well as blood-brain barrier (BBB) disruption mainly through endogenous upregulation of osteopontin. Clinical data proved the fact that there is an increased incidence of hypovitaminosis D among patients requiring treatment for cerebral aneurysms and a high prevalence of vitamin D insufficiency among SAH patients. Contrary to expectations, an association between vitamin D deficiency and outcomes in SAH patients could not be detected. However, in view of recent limited research data on this topic a final statement could not yet be made. Therefore, the investigators aimed to determine the effect of vitamin D on vasospasm discussing mechanistic evaluations of inflammation in SAH based on a translational study design including patient data to underline our experimental findings.
PCT No. PCT/JP93/01636 Sec. 371 Date Apr. 12, 1995 Sec. 102(e) Date Apr. 12, 1995 PCT Filed Nov. 10, 1993 PCT Pub. No. WO94/23750 PCT Pub. Date Oct. 27, 1994An aqueous drug composition having property of reversible thermosetting gelation for ophthalmic, dermatological and body cavitical use which comprises effective amount of drugs used for pharmaceutical therapy or diagnosis, methylcellulose, citric acid and polyethylene glycol and has a pH of 3 to 10, characterized in that said aqueous drug composition is fluid liquid before administration or application and forms gel at a body temperature of a local region immediately after administration or application.
We present the case of a male with end-stage diabetic nephropathy on haemodialysis who initially presented with acute-on-chronic digital ulceration. While awaiting vascular intervention, he became septic with abdominal pain and diarrhoea. Flexible sigmoidoscopy confirmed pseudomembranous colitis secondary to Clostridium difficile. Blood cultures grew Parabacteroides distasonis, a Gram-negative gut anaerobe. Enterobacter cloacae, another Gram-negative anaerobic gut bacilli, was grown in colonic cultures and swabs of the digital ulcers. We hypothesise that the pseudomembranous colitis increased gut translocation and thus led to the systemic spread of both gut anaerobes. This is the first reported case of Parabacteroides distasonis bacteraemia in the context of Clostridium difficile infection. Our patient recovered with antibiotics and went on to have vascular intervention for his digital ulceration.
Meningiomas are typically benign and asymptomatic, but complicated or symptomatic cases may necessitate immediate intervention. Specifically, a giant meningioma with high vascularization poses a surgical challenge due to increased risk. In this report, a case of a giant meningioma managed with preoperative embolization (POE) before surgery was presented. A 24-year-old woman presented with severe bilateral visual disturbances and chronic headaches. Upon examination, magnetic resonance imaging (MRI) showed a giant meningioma measuring 97 mm in maximum diameter. Subsequent angiography indicated a significant tumor blush, primarily supplied by the right anterior cerebral artery (RACA) and the right middle cerebral artery (RMCA), with additional dural supply from the distal branches of the right and left middle meningeal artery (R-L MMA). Following this, endovascular embolization was performed, achieving 75% occlusion of the MMA using polyvinyl alcohol (PVA). The tumor was subsequently resected, attaining Simpson grade 1 on the fifth day post-embolization. Theoretically, preoperative embolization offered several advantages, including tumor devascularization, reduced operative blood loss, improved tumor visualization, and potentially higher rates of achieving Simpson grades I or II resection. The MMA was frequently targeted for embolization in meningioma cases, with no additional neurological deficit observed afterward. The optimal timing for resection typically fell within 1-7 days after embolization. During surgery, the patient experienced 1000 ml of bleeding over a 7-hour duration. The results showed that preoperative embolization provided significant benefits in reducing bleeding, shortening operating time, and facilitating mass resection, thereby affecting long-term recurrence rates, reported at 9% over 10 years.
FIELD: medicine. SUBSTANCE: islet cells of newborn piglets pancreas are transplanted to patient. Before and after this operation antihistaminic preparations are injected. Additionally area of transplant is affected with ultrasound having frequency 0.880 MHz and intensity 0,3-0,4 W/cm 2 . The latter process is carried out since the second day after operation within 5-7 days. EFFECT: prevents rejection of transplant, improves its functioning.
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear.
METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg.
RESULTS: For FNA-Tg, the optimal cutoff value was 16.1 ng/mL (area under the curve (AUC)= 0.942). The optimal cutoff value for FNA-Tg/sTg was 1.42 (AUC = 0.933). The AUC for FNA combined with FNA-Tg yielded the highest value compared to other combined diagnostic methods (AUC = 0.955). It has been found that serum thyroglobulin (sTg) is positively correlated with FNA-Tg (Rs = 0.318), while serum thyroglobulin antibodies (sTgAb) is negatively correlated with FNA-Tg (Rs = -0.147). In cases where the TNM stage indicated N1b, the presence of large or high volume lymph node metastasis(HVLNM), lymph node lateralization/suspicion (L/S) ratio ≤ 2, ultrasound findings indicating lymph node liquefaction, calcification, and increased blood flow, patients with coexisting Hashimoto's thyroiditis (HT), a tumor size ≥10 mm, and postoperative pathology confirming invasion of the thyroid capsule, higher levels of FNA-Tg were observed. However, the subgroup classification of DTC and the presence or absence of thyroid tissue did not demonstrate any significant impact on the levels of FNA-Tg.
CONCLUSION: The findings of this study indicate that the utilization of FNA in conjunction with FNA-Tg is a crucial approach for detecting LNM in DTC. TNM stage indicated N1b, the presence of HVLNM, the presence of HT, lymph node L/S ratio, liquefaction, calcification, tumor diameter, sTg and sTgAb are factors that can impact FNA-Tg levels.In the context of clinical application, it is imperative to individualize the use of FNA-Tg.
An antimicrobial adhesive sheet containing an antimicrobial agent which exerts the antimicrobial activity not only on an attached site but also in the space in the vicinity of the attached site, and an antimicrobial method using the sheet. The antimicrobial adhesive sheet has a moisture permeability of at least 1,000 g/m 2 ·24 hrs as the whole sheet, where a non-aqueous adhesive layer containing a vaporizable antimicrobial agent is formed on one side of the support. As the support, non-woven fabric and porous plastic sheet are preferable. In case of non-porous plastic sheet, polyurethane resins and polyamide resins are preferably used. As the vaporizable antimicrobial agent, hinokitiol is preferable and inclusion compounds thereof may also be used. As the adhesive, an acrylic adhesive prepared by polymerizing a (meth)acrylic acid alkyl ester as the main component is preferably used.
Pathological hair-pulling, trichotillomania, has been defined as repetitive, intentionally performed pulling that causes noticeable hair loss and results in clinically significant distress or functional impairment. Trichotillomania appears relatively common with an estimated prevalence between 1-3%. Data on the pharmacological treatment of trichotillomania is limited to case reports and conflicting double-blind studies of serotonin reuptake inhibitors. One positive double-blind study of N-acetyl cysteine in adults was not successful when examined for children and adolescents. Available data on the treatment of trichotillomania in children are therefore limited.

Silymarin, a flavonoid and a member of the Asteraceae family, is extracted from the seeds of milk thistle (Silybum marianum) and is known to have antioxidative and anti-apoptotic properties. Furthermore, it has been demonstrated that its anti-oxidative activity is related to the scavenging of free radicals and activation of anti-oxidative defenses: increases in cellular glutathione content and superoxide dismutase activity. Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. In the frontal cortex one of the functions of dopamine is to increase the signal to noise ratio, increased dopamine correlating with increased frontal performance. Studies have shown that the higher cortical dopamine levels are associated with improved frontal cortical cognitive performance. Cortical inhibition is felt to be the basis for top-down control of motivated behaviors. A recent randomized controlled study with milk thistle was conducted in Iran Thirty five participants with moderate OCD were randomly assigned to 200 mg of milk thistle leaf extract or 10 mg of fluoxetine three times daily for eight weeks. Results revealed no significant difference in treatment effects between milk thistle and fluoxetine from baseline to endpoint as both interventions provided a highly significant reduction in symptoms. Silymarin or Milk Thistle may therefore offer promise for the treatment of individuals with trichotillomania.

The current pilot study examines the tolerability and efficacy of milk thistle in the treatment of trichotillomania in children and adults. The investigators hypothesize that milk thistle will reduce the severity of symptoms related to trichotillomania and improve patients' overall functioning.
A system and method for providing a consumer with dental services and products from a retail location, such as, for example, a local shopping mall. The dental service or product may include a teeth whitening product or service. The retail location is operated by a registered dental assistant or hygienist under supervision of a licensed off-site dentist. The dental assistant or hygienist uses an intra-oral camera and/or x-ray machine to take images of the customer’s teeth and/or mouth. The images are transmitted to the off-site dentist over a data communications network, The off-site dentist evaluates the images and approves or denies a request for a particular dental service or product. If approved, the product or service is dispensed from the retail location. The off-site dentist may also recommend that the customer see a specialist. In this case, a referral to a specialist in the customer’s area is made. An initial consultation with the specialist may also be conducted from the retail site, via video-conferencing technology.
The present disclosure concerns a polypeptide comprising a first three residue motif (from a N-terminus) and a second three residue motif, the first and second three residue motif optionally separated by 1 to 3 amino acid residue, and at least two C-terminus residues. The three residue motif is each represented by X 1 -X 2 -X 3 . Each X 1  is a residue independently selected from tryptophan, phenylalanine, tyrosine, histidine, an unnatural aromatic amino acid residue or a derivative thereof. Each X 2  and X 3  are independently any amino acid residue. X 1  and X 3  in each motif are connected to form a cyclophane moiety. At least one of the two C-terminus residues is an aromatic residue. The present disclosure also concerns a method of producing the polypeptide.
The face-to-face screening consist of two 20-minute consecutive consultations with a nurse and subsequently an anesthesiologist or PA. The nurse obtains basic patient health information, provides information on the upcoming hospital admission, and gives advice in lifestyle procedures around the surgery. The physician assesses the patient's health status based on co-morbidities, medication use, previous surgery, and lifestyle habits to predict preoperative risks and determine the optimal anesthetic technique. Additional diagnostics, such as blood tests or electrocardiogram, can be ordered and optional anesthetic techniques will subsequently be presented and discussed with the patient, after which informed consent will be obtained.
To determine feasibility of using the Computer Assisted Survivor Screening (CASS) as a routine screening measure for the survivor population. Specifically, to determine patient acceptance, time to completion, and burden associated with the CASS. To examine the potential utility of the CASS as a routine screening measure in the survivor population. To validate the CASS against the SCL-90-R screening measure. Calculate the sensitivity,specificity, positive and negative predictive values, diagnostic agreement and ROC curve of the CASS compared to the SCL-90. Determine the optimal cut-off scores to optimize agreement between the CASS and the SCL-90.