anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The sham tDCS consists in the same montage of the active tDCS, but the device is turned off 30 seconds after starting stimulation (without letting the patient notice it). The rest of the montage is kept identical to the active one during the 20 minutes session.
NEUPOGEN is a growth factor that primarily stimulates neutrophils. The granulocyte colony-stimulating factor (G-CSF) receptor through which filgrastim acts has also been found on tumor cell lines. The possibility that filgrastim acts as a growth factor for any tumor type cannot be excluded. The safety of filgrastim in chronic myeloid leukemia (CML) and myelodysplasia has not been established.

When NEUPOGEN is used to mobilize PBPC‚ tumor cells may be released from the marrow and subsequently collected in the leukapheresis product. The effect of reinfusion of tumor cells has not been well studied‚ and the limited data available are inconclusive.
Serious hypersensitivity reactions after administration of OXBRYTA have occurred in <1% of patients treated. Clinical manifestations may include generalized rash, urticaria, mild shortness of breath, mild facial swelling, and eosinophilia [see Adverse Reactions (6.1)].

Drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported in postmarketing experience with OXBRYTA [see Adverse Reactions (6.2)]. Patients who develop a combination of skin rash, fever, peripheral eosinophilia, and internal systemic organ involvement (e.g., hepatic, renal, pulmonary) while receiving OXBRYTA should undergo medical evaluation.

Advise patients of the signs and symptoms of severe hypersensitivity reactions, including DRESS. If hypersensitivity reactions occur, discontinue OXBRYTA and administer appropriate medical therapy. Do not reinitiate OXBRYTA in patients who experience these symptoms with previous use.
70 eligible subjects will be asked to undergo contrast-enhanced MRI studies of the breast containing the lesion. Subjects will be asked to fast for 6 hours prior to the imaging session. Each subject will be tested for glucose, and if the glucose is not too high, the subject will be injected with a dose of radioactive sugar (fluoro-deoxyglucose) which has been shown in other studies to accumulate in breast cancers. The subject will be asked to sit quietly for 30 minutes and to empty the bladder. The subject will then be asked to be re-examined in the MRI scanner with MRI contrast injection. The examination bed will be moved out of the MRI scanner and detectors of the radioactive sugar will be placed near the breast in order to obtain a positron emission mammogram for a 10-minute period. The subject will then leave the MRI suite.
Risk Summary

Based on its mechanism of action, ZYNYZ can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology (12.1)]. There are no available data on the use of ZYNYZ in pregnant women. Animal studies have demonstrated that inhibition of the PD‑1/PD‑L1 pathway can lead to increased risk of immune-mediated rejection of the developing fetus resulting in fetal death (see Data). Human IgG4 immunoglobulins (IgG4) are known to cross the placenta; therefore, retifanlimab-dlwr has the potential to be transmitted from the mother to the developing fetus. Advise women of the potential risk to a fetus.

In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.

Data

Animal Data

Animal reproduction studies have not been conducted with ZYNYZ to evaluate its effect on reproduction and fetal development. A central function of the PD-1/PD-L1 pathway is to preserve pregnancy by maintaining maternal immune tolerance to the fetus. In murine models of pregnancy, blockade of PD-L1 signaling has been shown to disrupt tolerance to the fetus and to result in an increase in fetal loss; therefore, potential risks of administering ZYNYZ during pregnancy include increased rates of abortion or stillbirth. As reported in the literature, there were no malformations related to the blockade of PD-1/PD-L1 signaling in the offspring of these animals; however, immune-mediated disorders occurred in PD-1 and PD-L1 knockout mice. Based on its mechanism of action, fetal exposure to retifanlimab-dlwr may increase the risk of developing immune-mediated disorders or altering the normal immune response.
Organelle stress exacerbates podocyte injury, contributing to perturbed lipid metabolism. Simultaneous organelle stresses can occur in the kidney in the diseased state; therefore, a thorough analysis of organelle communication is crucial for understanding the progression of kidney diseases. Although organelles closely interact with one another at membrane contact sites, limited studies have explored their involvement in kidney homeostasis. The endoplasmic reticulum (ER) protein, PDZ domain-containing 8 (PDZD8), is implicated in multiple-organelle-tethering processes and cellular lipid homeostasis. In this study, we aimed to elucidate the role of organelle communication in podocyte injury using podocyte-specific Pdzd8-knockout mice. Our findings demonstrated that Pdzd8 deletion exacerbated podocyte injury in an accelerated obesity-related kidney disease model. Proteomic analysis of isolated glomeruli revealed that Pdzd8 deletion exacerbated mitochondrial and endosomal dysfunction during podocyte lipotoxicity. Additionally, electron microscopy revealed the accumulation of abnormal, fatty endosomes in Pdzd8-deficient podocytes during obesity-related kidney diseases. Lipidomic analysis indicated that glucosylceramide accumulated in Pdzd8-deficient podocytes, owing to accelerated production and decelerated degradation. Thus, the organelle-tethering factor, PDZD8, plays a crucial role in maintaining mitochondrial and endosomal homeostasis during podocyte lipotoxicity. Collectively, our findings highlight the importance of organelle communication at the 3-way junction among the ER, mitochondria, and endosomes in preserving podocyte homeostasis.
PURPOSE: A sustained release tablet with a two-phase release-controlling system is provided to effectively control drug release. CONSTITUTION: A sustained release tablet contains a first release-controlling phase containing pregabalin or a salt thereof and a second release-controlling phase containing polyethylene oxide as a swelling polymer. The first release-controlling phase is uniformly dispersed over the second release-controlling phase. The first release-controlling phase additionally contains hydroxypropyl cellulose as a binder. The second release-controlling phase additionally contains crospovidone or sodium starch glycolate. [Reference numerals] (AA) Lyrica 150mg; (BB) Embodiment 5; (CC) Embodiment 13; (DD) Embodiment 20
Systems and methods are provided for determining an emotional state of a medical professional and dynamically generating clinical procedures that are adapted to the medical professional's emotional state, as well as an assessment of a medical device based on the determined emotional state. Observation data corresponding to a medical professional associated with a clinical procedure can be received and processed to determine an emotional state of the medical professional. The emotional state can be predicted using a first predictive model trained in a machine learning process. The determined emotional state can be provided to a second predictive model to provide one or more adapted clinical procedures. Device assessment data can also be used with the determined emotional state to determine an assessment of a medical device. The one or more adapted clinical procedures and the assessment of the medical device can be provided as an output.
599952 Disclosed herein is an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aids in delivering a lipid to the ocular surface. Specifically disclosed is an ophthalmic emulsion comprising: water forming an aqueous phase; oil forming an oil phase; a hydrophilic surfactant; a hydrophobic surfactant; a charged phospholipid; borate; and a mucoadhesive galactomannan polymer; wherein: the oil phase is in droplets within the aqueous phase and the droplets have an average diameter that is no greater than about 1000 nm, but is at least 10 nm; and the borate and galactomannan polymer cooperatively act to form a gel upon instillation of the emulsion in an eye of an individual. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
OBJECTIVES: To explore the prognostic factors of patients with low-grade optic pathway glioma (OPG) and the optimal treatment to reduce the incidence of postoperative hydrocephalus.
PATIENTS AND METHODS: This single-center study retrospectively analyzed data from 66 patients with OPGs who underwent surgery. The patients were followed, and overall survival (OS) and progression-free survival (PFS) were determined. The effects of different treatments on the hydrocephalus of patients were compared.
RESULTS: Postoperative hydrocephalus was identified as a factor to increase the risk of mortality by 1.99-fold (p = .028). And, 5-year survival rate was significantly lower among patients with postoperative hydrocephalus (p = .027). The main factors leading to preoperative hydrocephalus in patients are large tumor volume and invasion into the third ventricle. Gross total resections (GTR) could reduce the risk of long-term hydrocephalus (p = .046). Age younger than 4 years (p = .046) and tumor invasion range/classification (p = .029) are the main factors to reduce the five-year survival rate. Postoperative radiotherapy (RT) and chemotherapy (CT) had no significant effects on OS. Extraventricular drainage (EVD) was not associated with perioperative infection (p = .798 > .05) and bleeding (p = .09 > .05). Compared with 2 stage surgery (external ventricular drainage or ventriculoperitoneal shunt (VPS) was first placed, followed by tumor resection), 1 stage surgery (direct resection of tumor) had no complication increase.
CONCLUSIONS: Postoperative hydrocephalus is mostly obstructive hydrocephalus, and it is an important factor that reduces the OS of patients with low-grade OPGs. Surgery to remove the tumor to the greatest extent improves cerebrospinal fluid circulation is effective at reducing the incidence postoperative hydrocephalus. For patients whose ventricles are still dilated after surgery, in addition to considering poor ventricular compliance, they need to be aware of the persistence and progression of hydrocephalus.
Obstructed urine flow is known to cause structural and functional kidney damage leading to renal fibrosis. However, limited information is available on the change in kidney lipids during urinary tract obstruction. In this study, we investigated the change in lipidome in a mouse model with unilateral ureteral obstruction (UUO). The establishment of the UUO model was confirmed by histopathological examination using transmission electron microscopy. Untargeted liquid chromatography/mass spectrometry was carried out over a time course of 4 and 7 days. Compared to the sham control, the UUO kidney at 7 days showed dilatation of the renal tubule with loss of brush borders and thickening of the capillary endothelium. In the kidney lipidomes obtained from the UUO 7 days group compared to the control, a significant decrease of ceramide, sphingomyelin, phosphatidylcholine, lysophospholipids, and phosphatidylethanolamine was observed, whereas cholesteryl esters, free fatty acids, phosphatidylglycerol, and cardiolipins were significantly increased. The present study revealed the disturbed lipid metabolism in the UUO model, which may provide a clue to potential lipid pathways and therapeutic targets for the early stage of renal fibrosis.
The invention provides a method of identifying a compound that alters vigilance. The method consists of contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. A candidate compound that alters the vigilance property in the contacted invertebrate is identified as a compound that alters vigilance. The invention also provides a method of identifying a vigilance enhancing compound that modulates homeostatic regulation or a vigilance diminishing compound that modulates homeostatic regulation. The method consists of contacting an invertebrate with a compound that increases or decreases vigilance, and determining the effect of the compound on a homeostatic regulatory property of vigilance. A compound that alters the homeostatic regulatory property is characterized as being a vigilance enhancing compound or a vigilance diminishing compound that modulates homeostatic regulation.
<P>PROBLEM TO BE SOLVED: To provide an immunostimulation composition which includes fucoidan and lactobacillus, and has a high IL-10 production promotion action.  <P>SOLUTION: Fucoidan derived from Undaria pinnatifida of 0.1-10 pts.wt. is added to lactic acid bacterium, based on 1 pt.wt. of fungus belonging to genera Tetragenococcus, Pediococcus, Lactobacillus or the like, and is cultivated, thereby the immunostimulation composition having an IL-12 production promotion action and also a high IL-10 production promotion action can be obtained. The immunostimulation composition is anticipated to have a high effect in ameliorating a symptom of I type allergy or a symptom relaxation of ulcerative colitis or the like which is an inflammatory disease.  <P>COPYRIGHT: (C)2011,JPO&INPIT
<P>PROBLEM TO BE SOLVED: To obtain an excellent natural product-derived antihypertensive that contains a mung bean protein hydrolyzate.  <P>SOLUTION: The antihypertensive comprises a mung bean protein decomposition product. The food and the medicine or the quasi medicine comprise the antihypertensive. The mung bean protein decomposition product is representatively obtained by hydrolyzing a mung bean-derived protein with a protease. Since the antihypertensive has inhibitory effect on vasodepressor and the vasopressor and has action persistence of the effect, the antihypertensive controls blood pressure during sleeping or early in the morning. When the antihypertensive is taken for a long period of time, since the effect maintains even by cessation of the medicine, blood pressure will not abruptly rise even in forgetting administration. The antihypertensive is suitable for everyday and long-term intake by the characteristics.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Liposomal and/or nano-liposomal encapsulated HSP90a, HPf polypeptide (115 aa) and novel polypeptides HPf ΔC1 (101 aa) and HPfΔC2 (87 aa), as well as methods for manufacturing/preparing and using the compositions, are disclosed. Chimeric fusion proteins that include an HSP90a, HPf-polypeptide, HPf ΔC1 or HPfΔC2 polypeptide are presented. Transformed cell lines and expression vectors capable of expressing the chimeric fusion proteins, are provided. Methods for producing large amounts of recombinant HSP90a, HPf polypeptide, HPf ΔC1 or HPfΔC2 polypeptide, using expression vectors and transformed cell lines, are described. Topical and other delivery form preparations and methods for using the preparations, including methods for improving skin conditions (atopic dermatitis, wrinkles, skin elasticity, dark spots (over pigmentation), overall skin rejuvenation, skin ageing) for therapeutic and cosmeceutical uses are presented. Liposomal preparations and methods for using them for enhancing wound healing and methods for suppressing subcutaneous fat cell differentiation and reducing subcutaneous fat formation are disclosed.
PURPOSE:To obtain a perioperative infusion solution preparation capable of effectively correcting electrolytic balance in the surgical operation stage. CONSTITUTION:A perioperative infusion solution containing an electrolyte and a saccharide in these ranges shown in the table and adjusted to pH 4.0-6.0 by hydrochloric acid. In this perioperative infusion solution, sodium content is decreased and simultaneously acetic acid is used as an alkalization agent. Thereby, edema inclination of intercellular substances due to storage of sodium in a human body is not shown and acetic acid used as an alkalization agent is useful as a perioperative in fusion solution for correcting electrolytic balance, because it has characteristics capable of efficiently being metabolized and utilized not only in liver, but also in muscle of the whole body. This preparation has advantage capable of rapidly injecting also into the body of a patient of hepatic insufficiency or circulation insufficiency in large quantities. Since this preparation is pharmacologically stable, long-term storage is made possible.
Patients in this group will be receiving therapy for pain control with acetaminophen and ibuprofen only. They will be asked to complete a pain diary which will be used to determine the level of pain control achieved with this regimen. The diary will be completed by post-operative day 14. A post-operative appointment between 4-8 weeks will be scheduled and the patient and caregiver will return the diary.
Disease transmission is dependent on a variety of factors, including the characteristics of an event, such as crowding and shared accommodations, the potential of participants having prolonged exposure and close contact with infectious individuals, the type of activities, and the characteristics of the participants, such as their age and immunity to infectious agents [1-3]. Effective control of outbreaks of infectious diseases requires rapid diagnosis and intervention in high-risk settings. As a result, syndromic and event-based surveillance may be used to enhance the responsiveness of the surveillance system [1]. In public health, surveillance is collecting, analyzing, and interpreting data across time to inform decision-making and aid policy implementation [1]. In this review article we aimed to provide an overview of the principles, types, uses, advantages, and limitations of surveillance systems and to highlight the importance of early warning systems in response to the information received by disease surveillance. The study conducted a comprehensive literature search using several databases, selecting, and reviewing 78 articles that covered different types of surveillance systems, their applications, and their impact on controlling infectious diseases. The article also presents a case study from the Hajj gathering, which highlighted the development, evaluation, and impact of early warning systems on response to the information received by disease surveillance. The study concludes that ongoing disease surveillance should be accompanied by well-designed early warning and response systems, and continuous efforts should be invested in evaluating and validating these systems to minimize the risk of reporting delays and reducing the risk of outbreaks.
HXe MRI provides a diversity of imaging techniques for interrogating pulmonary function and lung microstructure. The most mature of these techniques utilizes HXe spin-density MRI to depict regional lung ventilation. Prior work suggests that ventilation imaging has utility in all obstructive lung diseases. This is a Phase II clinical trial to assess HXe MRI capability of providing qualitative and quantitative clinical information regarding lung ventilation. Proton and xenon images will be acquired within single breath holds on 28 subjects per year, including healthy volunteers and patients with COPD and asthma. All studies will include repeat scans and Pulmonary Function Tests (PFT). Ventilation scans with Technetium-99m (Tc-99m) diethylene-triamine-pentaacetate (DTPA) aerosol scintigraphy will be acquired on lung patients.

The primary goal of this aim is to validate the effectiveness of HXe ventilation MRI for delineating regions of normal and abnormal lung ventilation. To validate the regional depiction of ventilation, HXe MRI ventilation will be compared with nuclear medicine Tc-99m DTPA ventilation scintigraphy. The comparatively low spatial and temporal resolution of ventilation scintigraphy will limit this study to demonstrating only that HXe MRI ventilation is not inferior to the current clinical standard. Additionally, the concordance between measurements of the whole lung volume from both proton MRI and HXe MRI with PFT, the current clinical standard for lung volume measurement, will be assessed as a secondary outcome of the study.
OBJECTIVE: The objective of this study was to assess the relationship between Body Mass Index (BMI), dietary habits, physical activity, and health perception among female university students in Morocco.
METHODS: The study was conducted at a Moroccan university among female students from the Faculty of Sciences Ain-Chock in Casablanca. Participants were given a self-administered questionnaire that evaluated sociodemographic factors, dietary habits, food group consumption, physical activity, and self-assessed health status. Data collection took place from February 2023 through the end of April 2023.
RESULTS: A total of 335 students aged 18 to 29 years participated in the survey. The study revealed that 72.5% of the participants were within the normal weight range (BMI 18.5-24.9 kg/m²), while 15.9% were classified as overweight and 3.9% as obese. Additionally, 47.9% of the participants engaged in physical activity, with 30.2% dedicating more than 45 minutes to their activities. The health perception was found to be related to weight classification, with poor health perception most commonly associated with the "18.5-25" BMI range (57.8%).
CONCLUSION: The study sheds light on the intricate interaction between weight, health, and lifestyle in Morocco. The frequency of normal-weight persons and active participation indicates university students' health awareness. The prevalence of overweight and obesity, on the other hand, need ongoing health measures. These findings help to build focused methods for promoting healthier lives in Morocco, utilizing educational institutions as health promotion platforms.
PROBLEM TO BE SOLVED: To obtain a cleansing composition having good stability and use property, refreshing feeling, wet feeling and smoothness by combining potassium salt of a higher fatty acid with a specific ampholytic surfactant and specific high-molecular weight silane in specific amounts. SOLUTION: This composition is obtained by combining (A) (5-30wt.%) high- purity potassium salt of fatty acid with (B) (2-20wt.%) alkyldimethylaminoacetic acid betaine and (C) an emulsion of high-molecular weight silicone represented by the formula [R1 is methyl or phenyl; R2 is methyl or OH; (m) is 800-5,000  91476/28}, obtained by emulsion polymerization and having 0. 25-30μm average particle diameter (in an amount of 0.01-10wt.% as high-molecular weight silicone). For example, coconut oil fatty acid potassium salt, palm oil fatty acid potassium salt or the like is preferably used as the component A. The blend weight ratio of the component A to the component B is preferably in the range of (5/) to (1/1). The composition has good foaming power, detergency and foam quality.