anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cerebral infarction, or ischemic stroke, is a common yet challenged illness with four telltale signs (high occurrence rate, high incapacitate rate, high mortality rate, and high recurrence rate), posing not only a threat to a man's health and life, but also imposing a burden to the society and his loved ones. As such, seeking a cure has always been the hot topic in this field of research. With regard to the illness' high incapacitate and recurrence rates, it has become apparent that the treatment methods used in the recuperating stages of stroke are very significant to the patient, allowing him the chance to regain his health and increase his quality of life. In Chinese medical terms, the pathogenesis key of stroke is a deficiency in the vitals of the body coupled with superficiality extremities. As such, in the recuperating stage of the stroke, a lack of Qi accompanied with blood stasis syndrome is often observed. Hence, improving Qi and promoting blood circulation is essential during treatment. Research further supports that this treatment method is highly effective in treating cerebral infarction, but the mechanism involved is still incomprehensible, largely due to the fact that the pathology of cerebral infraction is highly complicated, and that Chinese medicine is multi-leveled, multi-channeled, with multi-targets. To further study the relationship of Qi and blood in cerebral infraction, patients in the recuperating stages with deficiency in Qi and blood stasis underwent observation in a double blind clinical research. The patients were sorted in random into groups: improving Qi group, promoting blood circulation group, improving Qi and promoting blood circulation group, and the control group. Each group of patients was given the standard Western medicine treatment, coupled with Chinese medicine treatments with respect to their sorted groupings. The treatment lasts for 12 weeks and 360 clinical cases were studied. Testing methods used include enzyme linked immunosorbent assay, Western Blot, FQ RT-PCR, LC-MS, and radiology. Through the relations between Neurotransmitter - endocrine hormone - immune cytokine network, blood rheology, vascular structure and endothelial function, interactions involving vasoactive substances with vascular endothelium and blood cells, it is hoped that the biological basis of cerebral infraction's deficiency in Qi and blood stasis syndrome can be deciphered. This will aid in the understanding of the whole process of causing the syndrome, deciphering the therapeutic mechanism involved during treatment, as well as determining the relationship between Qi, blood and blood vessels.
BACKGROUND: Cervical dystonia is a movement disorder typically characterized by a patterned and twisting movement of sustained or intermittent muscle contractions. Recently, new clinical trials are emerging, highlighting the potential benefit of physiotherapy (PT) on disease outcomes. Thus, the objective of this review is to update the effectiveness of PT on cervical dystonia disease outcomes and subsequently perform a meta-analysis.
METHODS: Interventional studies published in English with adult patients with isolated cervical dystonia following a physiotherapy program were included. Relevant articles were searched in PubMed (MEDLINE), Web of Science, and Scopus. Cochrane and Joanna Briggs Institute risk of bias checklists were used for quality reporting. Meta-analysis was done using Review Manager 5.3 statistical software and a pooled mean difference for pain was presented.
RESULTS: Fourteen articles were included in the review and two articles were included in the meta-analysis. The meta-analysis revealed that PT intervention had a significant effect on pain reduction scale (-5.00, 95% CI -6.26, -3.74) when used as an additional therapy with botulinum toxin (BoNT) injection. Additionally, findings indicate a possible positive effect of PT disease severity, disability, and quality of life.
CONCLUSIONS: Physiotherapy in addition to BoNT is recommended to decrease pain. The findings suggest a reduction of disease severity, disability, and improvement in quality of life. The variety in the type and duration of PT interventions did not allow a clear recommendation of a specific type of PT.
PURPOSE: For patients who seek to camouflage cancer-related hair loss, cranial prostheses such as wigs and hair pieces exist. We sought to determine the availability of yaki-textured, type IV curls, and afro wigs at boutiques in Comprehensive Cancer Centers (CCCs).
METHODS: The 56 CCCs in the United States were surveyed to see whether they had an affiliated wig boutique for patients experiencing hair loss. Boutique workers were then asked a series of seven questions regarding cranial prostheses options for patients seeking yaki-textured, type IV curls, and afro wigs. The availability of wigs was compared with US Census data on population size and density of Black residents.
RESULTS: Of the 56 CCCs, 27 (46%) institutions had active affiliated hair boutiques. We were able to reach 19 (70%) of the 27 boutiques, of which 53% (n = 10) offered yaki-textured wigs, 37% (n = 7) offered type IV curls or afro wigs, and 47% (n = 9) offered neither. Two additional boutiques offered in-store catalogs for Black patients who were interested in naturally appearing wigs. Although two institutions offered a wig bank that was free to all patients, neither had yaki-textured or afro wigs in stock. There was no significant relationship between population size or density of Black residents and availability of these wigs.
CONCLUSION: Many Black patients undergoing cancer treatment interested in cranial prosthesis do not have consistent access to wigs with textures comparable with type IV hair at CCCs. With increased inventory of racially inclusive wigs, partnerships with third-party vendors, and support for the previous authorization process, we can better support Black patients experiencing cancer-related hair loss.
The invention discloses a formula of a traditional Chinese medicine for treating oral ulcer. The unit dosage of the traditional Chinese medicine comprises 10g of unprocessed rehmannia root, 5g of bamboo leaves, 10g of fructus forsythia, 1.5g of Sichuan coptis root, 10g of radix ophiopogonis, 15g of couchgrass root and 5g of raw licorice root tip. The above medical materials are weighed according to the above weight ratio and are decocted in water. Each dosage of the decoction is taken every day. The traditional Chinese medicine solves the problem that the conventional treatment drug has a high recurrence rate and large side effect, has a long use period, causes addiction, has a high recurrence rate after drug discontinuance and cannot thoroughly cure diseases. The traditional Chinese medicine is suitable for treatment on oral ulcer.
Participants will be screened according to a personalised timetable based on their estimated 5-year risk of developing breast cancer: with a mammography and/or tomosynthesis every 1-4 years with or without ultrasound depending on breast density. Risk estimation will be performed using the following variables: age, family history, previous history of benign breast biopsy, personal hormone and reproductive history, breast mammographic density and genotyping (polygenic risk score). Risk assessment will be conducted using Mammorisk™ for women with at most one first-degree relative with breast or ovarian cancer and using Tyrer-Cuzick™ risk score for those women with more than one first-line first degree relative with breast or ovarian cancer.
The invention relates to a medicine for treating pharyngolaryngitis. At present, there are considerable methods for treating pharyngolaryngitis, e.g., it is generally advocated in western medicine to use gargle like chlorhexidine, a compound borax solution, etc., or to retain cydiodine buccal tablets, Angi lozenge, g bacterium lozenge and the like in mouth. The above-mentioned medicaments result in environmental disorder in oral cavity when used for a long time. The medicine provided in the invention is obtained by grinding bushy sophora and balloonflower root into fine powder and making pills with honey. Pharyngolaryngitis corresponds to hypopyretic laryngalgia in traditional Chinese medicine, and the cause and pathogenesis of the disease are rising of deficiency fire and dystrophy of throat caused by deficiency in lung, kidney and yin. It is proper to nourish lung and kidney, clear heat, reduce phlegm, moisten throat and disinhibit the throat for treatment of pharyngolaryngitis. According to experience, the traditional Chinese medicine has the advantages of stable dosage and components, direct contact with an affected part, fast action and no side effects; correct application of the medicine is favorable for treatment of pharyngolaryngitis.
The invention discloses an anti-HIV monoclonal antibody and a preparation method and application thereof. The monoclonal antibody comprises a heavy chain and a light chain, and is specifically shown in a sequence table. The invention uses YU2 gp140 trimer and AE1gp140 trimer double antigens to sort specific single memory B cells of a long-term non-progressor infected with HIV, obtains paired antibody heavy chain and light chain genes, and screens to obtain the anti-HIV monoclonal antibody 7D 5. The antibodies have high binding activity and limited neutralizing activity. The optimized antibody gene cloning scheme improves the amplification efficiency of heavy chains and light chains. The discovery of the monoclonal antibody not only provides an alternative medicine for preventing and treating HIV infection, but also provides a technical reference for developing monoclonal antibody medicines for resisting virus infection.
PURPOSE: To obtain castanospermine useful as an antidiabetic agent by isolating from seeds of Castanospermum australe through processes of extraction, washing, elution and concentration. CONSTITUTION: Crushed seeds of Castanospermum australe are extracted with a mixture of water and 2-propanol. Subsequently, the extract is washed with petroleum ether, the washed extract is subjected to chromatography on an acidic resin, and the objective material is eluted with ammonium hydroxide. The elute is again subjected to chromatography on a basic resin, the material is eluted with water, and the obtained aqueous elute is concentrated. Subsequently, the product is triturated with acetone to obtain the objective castanospermine. Castanospermine has digestive enzyme-inhibiting activity, and it is useful as an antidiabetic agent, and further as an inhibitor of increased lipogenesis.
This trial will examine the comparative effectiveness and cost-effectiveness of a web-based HIV, hepatitis and STI prevention intervention when offered to youth in outpatient, community-based substance abuse treatment as directly compared to a traditional HIV (and infectious disease) prevention intervention. We will assess the comparative effectiveness and cost-effectiveness of these interventions by primarily examining changes from pre- to post-intervention in accurate HIV/disease prevention knowledge, intentions to engage in safer sex and HIV risk behavior. Additionally, we will examine the extent to which the interventions impact relevant skills acquisition (e.g., communication skills, negotiation skills and condom use skills), attitudes toward safer sex and self-reported substance use, as well as the acceptability of each intervention. We also plan to evaluate youth at both 1 and 3 month post-intervention to examine the durability of effects (including any differential durability of effects across intervention conditions). The web-delivered prevention intervention to be evaluated in this study has the potential to allow for a complex intervention to be delivered at a low cost, without increasing demands on staff time or training needs, and may thereby expand the reach of evidence-based prevention for youth in substance-abuse treatment.

This study will be conducted at three collaborating, community-based adolescent substance abuse treatment programs all of which are housed within the Daytop Village network of services and are located in New York City: (1) Daytop Village's Brooklyn Outreach Center; (2) Daytop Village's Bronx Outreach Center; and (3) Daytop Village's Queens Outreach Center. We expect to recruit approximately one third of the total number of participants from each site.

A total of up to 160 (no fewer than 120) adolescent participants will be enrolled in this study. Participants will be randomly assigned to one of the two study conditions in an intent-to-treat design (n=60-80 per group): (1) computer-delivered intervention or (2) traditional (person-delivered intervention). Participants in the traditional prevention intervention condition will complete two sessions (of approx. one hour in duration) across the course of a week, conducted by a trained HIV (and infectious disease) prevention educator; these sessions will typically be conducted in small groups of 2-4 participants but may be offered individually. Participants in the computer-delivered intervention condition will complete an interactive, web-based HIV, hepatitis and STI prevention program instead of the traditional, person-delivered prevention intervention. Youth will be asked to complete a customized plan of approximately 2-4 hours in length using the web-based tool; participants will complete two 60-minute sessions per week until they complete their customized plan. Participants will access this intervention using dedicated computer stations set up at their substance abuse treatment program.
EMI arm: participants in this arm will receive two ecological momentary assessment (EMA) prompts and one econological momentary intervention (EMI) prompt daily. The EMA prompts would be identical to the ones in the EMA arm without the video clip at the end. The EMI prompt would contain an interactive task designed to counter ruminative thoughts. Examples of the interactive tasks include: mindfulness exercises (mindful walking), cognitive reappriasal, strengths recognition, etc. Each EMI prompt would last around 3-5 minutes.
NEW MATERIAL:The 1-substituted-2-phenylindole derivative of formulaI(R1 is 3-12C alkyl or 3-12C alkenyl; R2 is OH, carboxyl, or lower alkoxycarbonyl; n is 0-3) and its salt. EXAMPLE:1-n-Propyl-2-(4-carboxymethylphenyl)indole. USE:Remedy for asthma, allergic dermatitis, allergic rhinitis, etc. It specifically inhibits the lipoxygenase of polybasic unsaturated fatty acid. The production of peroxyfatty acid is effectively suppressed, and the compound is extremely useful to protect the living tissue from the peroxide. PROCESS:The compound of formulaIor its salt is prepared, e.g. by reacting the compound of formula II or its salt with the compound of formula III or its salt,  and cyclizing the resultant compound of formula IV or its salt.
In recent years, the problem of rehospitalization has come under intense focus as a major contributor to preventable morbidity and escalating healthcare costs. Substance use disorders are strongly associated with poor health outcomes and highly inefficient use of healthcare services, including repeat hospitalizations. Interventions that increase adherence to recommendations for outpatient medical care and substance abuse treatment could potentially help recently-hospitalized individuals with substance use disorders to avoid unnecessary rehospitalization, associated morbidity, and medical expenses. The current study is a randomized controlled trial comparing the effectiveness of Navigation Services to Avoid Rehospitalization (NavSTAR) vs. Treatment-as-Usual (TAU) for hospital patients with co-occurring medical problems and substance use disorders. Applying Andersen's theoretical model of health service utilization, NavSTAR will employ the promising strategies of Patient Navigation and motivational interventions to facilitate engagement in outpatient medical and substance abuse treatment, thereby lowering the likelihood of rehospitalization. Patient Navigators embedded within the substance abuse consultation liaison service at a large urban hospital will deliver patient-centered, proactive navigation and motivational services initiated during the hospital stay and continued for 3 months post-discharge. Participants randomized to TAU will receive usual care from the hospital and the substance abuse consultation liaison service, which includes referral to substance abuse treatment but no continued contact post-hospital discharge. Participants will be assessed at study entry and again at 3-, 6-, and 12-months follow-up on various measures of healthcare utilization, substance use, and functioning. The primary outcome of interest is time-to-rehospitalization through 12 months. In addition, a range of secondary outcomes spanning the medical and substance abuse service areas will be assessed. The study will include an economic evaluation of the cost, incremental cost-effectiveness, and cost-benefits of NavSTAR from the service provider perspective.
BACKGROUND: Psoriasis is a chronic inflammatory disease that causes significant disability. However, little is known about the underlying metabolic mechanisms of psoriasis. Our study aims to investigate the causality of 975 blood metabolites with the risk of psoriasis.
MATERIALS AND METHODS: We mainly applied genetic analysis to explore the possible associations between 975 blood metabolites and psoriasis. The inverse variance weighted (IVW) method was used as the primary analysis to assess the possible association of blood metabolites with psoriasis. Moreover, generalized summary-data-based Mendelian randomization (GSMR) was used as a supplementary analysis. In addition, linkage disequilibrium score regression (LDSC) was used to investigate their genetic correction further. Metabolic pathway analysis of the most suggested metabolites was also performed using MetaboAnalyst 5.0.
RESULTS: In our primary analysis, 17 metabolites, including unsaturated fatty acids, phospholipids, and triglycerides traits, were selected as potential factors in psoriasis, with odd ratios (OR) ranging from 0.986 to 1.01. The GSMR method confirmed the above results (β = 0.001, p < 0.05). LDSC analysis mainly suggested the genetic correlation of psoriasis with genetic correlations (rg) from 0.088 to 0.155. Based on the selected metabolites, metabolic pathway analysis suggested seven metabolic pathways including ketone body that may be prominent pathways for metabolites in psoriasis.
CONCLUSION: Our study supports the causal role of unsaturated fatty acid properties and lipid traits with psoriasis. These properties may be regulated by the ketone body metabolic pathway.
PURPOSE:The titled increasing agent containing human erythropoietin as an active ingredient. CONSTITUTION:A megakaryocyte and blood platelet based increasing agent obtained by blending human erythropoietin as an active ingredient with other ingredients. The human erythropoietin can be isolated and purified from human urine, particularly urine of a patient with anemia caused by Taenia solium or aplastic anemia. Since the amount of the erythropoietin in the human urine is very small, it is difficult to obtain the erythropoietin in a large amount. However, a method for linking a gene capable of coding the human erythropoietin to a vactor containing replicon capable of relicating in eucaryotes or procaryotes, e.g. Escherichia coli or Bacillus subtilis, etc., to form a recombinant DNA material, expressing the gene of the above-mentioned recombinant DNA material in a suitable host cell and isolating from the culture fluid thereof is advantageous. The dose is 0.1-500mug/adult and administered 1-7 times a week as an oral agent or injection, etc.
AIM: Clusters of group B Streptococcus (GBS) infections in neonatal intensive care units (NICU) are poorly documented. We aimed to assess GBS cross-transmission during an outbreak of GBS sepsis.
METHODS: The study was carried out between October and November 2021 in a French University Hospital. Neonatal intensive care unit (NICU) patients with GBS sepsis were included. Clinical data were retrieved from electronic patient records. Group B Streptococcus isolates were characterized at the molecular level using capsular genotyping and whole-genome sequencing (WGS).
RESULTS: The outbreak of GBS sepsis affected three very preterm neonates with a gestational age of less than 26 weeks, including one recurrent male index case aged 26 days, and two female secondary cases aged 5 and 17 days. The microbiological investigation identified a GBS isolate of capsular type III and Sequence Type 17 as responsible for the four infectious episodes. Whole-genome sequencing confirmed the identity between the isolates. The outbreak and the results of the microbiological investigations led to an immediate reinforcement of hygiene measures.
CONCLUSION: Clustered cases of GBS infections in NICU and horizontal transmission of the hypervirulent GBS Sequence Type 17 are likely underestimated. Prospective investigation of all nosocomial cases using WGS should contribute to improving vigilance regarding GBS cross-transmission and infection prevention.
Neuropathy is a disturbance of function or a pathological change in nerves causing poor health and quality of life. A proportion of chronic pain patients in the community suffer persistent neuropathic pain symptoms because current drug therapies may be suboptimal so there is a need for new therapeutic modalities. This study investigated the neuroprotective flavonoid, 6-methoxyflavone (6MF), as a potential therapeutic agent and gabapentin as the standard comparator, against neuropathic models. Thus, neuropathic-like states were induced in Sprague-Dawley rats using sciatic nerve chronic constriction injury (CCI) mononeuropathy and systemic administration of streptozotocin (STZ) to induce polyneuropathy. Subsequent behaviors reflecting allodynia, hyperalgesia, and vulvodynia were assessed and any possible motoric side-effects were evaluated including locomotor activity, as well as rotarod discoordination and gait disruption. 6MF (25-75 mg/kg) antagonized neuropathic-like nociceptive behaviors including static- (pressure) and dynamic- (light brushing) hindpaw allodynia plus heat/cold and pressure hyperalgesia in the CCI and STZ models. 6MF also reduced static and dynamic components of vulvodynia in the STZ induced polyneuropathy model. Additionally, 6MF reversed CCI and STZ suppression of locomotor activity and rotarod discoordination, suggesting a beneficial activity on motor side effects, in contrast to gabapentin. Hence, 6MF possesses anti-neuropathic-like activity not only against different nociceptive modalities but also impairment of motoric side effects.
PURPOSE:To obtain the subject paste, containing glass powder, a water-soluble polymer and water and stable for a long period and a kit for preparing dental glass ionomer cements composed of the subject paste and an aqueous solution of a polycarboxylic acid. CONSTITUTION:The subject paste is produced by blending 55-90wt.% glass powder with 0.1-2.0wt.% water-soluble polymer (e.g. methyl cellulose or polyvinyl alcohol) and 9.9-44.9wt.% water. A dental glass ionomer cement composition is produced from the above-mentioned paste and an aqueous solution of a polycarboxylic acid (e.g. a 40-75wt.% aqueous solution of polyacrylic acid). The aforementioned paste has the following advantages. Since the glass powder is in a pasty form, scattering will not occur without aggregation of the powder by moisture absorption. A constant rate-discharging device can be utilized to accurately carry out weighing, etc. Furthermore, kneading with the aqueous solution of the polymer is very simply completed in a short time to afford sufficient operating time.