anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating pulmonary fibrosis and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 45 parts of radix rehmanniae, 18 parts of cornus officinalis, 18 parts of glossy privet fruit, 18 parts of radix achyranthis bidentatae, 18 parts of semen cuscutae, 9 parts of schisandra chinensis, 3 parts of gecko, 9 parts of tangerine pith, 9 parts of loofah sponge and 3 parts of pseudo-ginseng powder. The invention also comprises the application of the traditional Chinese medicine composition in preparing a medicine for treating pulmonary fibrosis diseases. Its advantages are: 1. the raw materials and the proportion thereof are optimized, and clinical test results show that the traditional Chinese medicine composition can obviously resist pulmonary fibrosis, is used for treating pulmonary interstitial fibrosis, and has the advantage of obvious effect. Animal experiments show that: the traditional Chinese medicine composition can improve the pulmonary fibrosis of a model rat by promoting autophagy. 2. The raw materials of the invention conform to the compatibility principle of monarch, minister, assistant and guide, and have the effects of tonifying kidney and receiving qi, and dredging collaterals and removing paralysis.
Type 2 diabetes (T2D) represents a major medical and public health problem. The ability to prevent or delay T2D by modifying some of its risk factors has been hypothesized for several decades. Indeed, the slow and gradual deterioration of glycaemia prior to the diabetes diagnosis constitutes a period during which interventions could be effective in preventing T2D. Lifestyle modifications demonstrated that modest weight loss (at least 7% of initial weight) and moderate to intense physical activity of at least 150 minutes per week, markedly and significantly delayed the onset of T2D in subjects at high risk of developing the disease. Pharmacological interventions indicated that metformin should be considered, particularly in young patients (< 60 years) with a body mass index ≥ 35 kg/m², and in women with a history of gestational diabetes. Bariatric surgery, which allows significant weight loss in subjects with severe or morbid obesity, has also demonstrated important preventive effectiveness and metabolic surgery in now considered in at-risk patients with less severe obesity. In conclusion, in overweight or obese adults at high risk of developing T2D, treatment aimed at losing weight (including bariatric surgery) and increasing physical activity should be implemented, and a pharmacotherapy might be considered case by case.
BACKGROUND: Lower body negative Pressure (LBNP)-induced hypovolemia is simulating acute hemorrhage by sequestrating blood into lower extremities. Bioelectrical Impedance Analysis (BIA) is based on the electrical properties of biological tissues, as electrical current flows along highly conductive body tissues (such as blood). Changes in blood volume will lead to changes in bioimpedance. This study aims to study changes in upper (UL) and lower (LL) extremities bioimpedance during LBNP-induced hypovolemia.
METHODS: This was a prospective observational study of healthy volunteers who underwent gradual LBNP protocol which consisted of 3-minute intervals: at baseline, -15, -30, -45, -60 mmHg, then recovery phases at -30 mmHg and baseline. The UL&LL extremities bioimpedance were measured and recorded at each phase of LBNP and the percentage changes of bioimpedance from baseline were calculated and compared using student's t-test. A P-value of < 0.05 was considered significant. Correlation between relative changes in UL&LL bioimpedance and estimated blood loss (EBL) from LBNP was calculated using Pearson correlation.
RESULTS: 26 healthy volunteers were enrolled. As LBNP-induced hypovolemia progressed, there were a significant increase in UL bioimpedance and a significant decrease in LL bioimpedance. During recovery phases (where blood was shifted from the legs to the body), there were a significant increase in LL bioimpedance and a reduction in UL bioimpedance. There were significant correlations between estimated blood loss from LBNP model with UL (R = 0.97) and LL bioimpedance (R = - 0.97).
CONCLUSION: During LBNP-induced hypovolemia, there were reciprocal changes in UL&LL bioimpedance. These changes reflected hemodynamic compensatory mechanisms to hypovolemia.
Consumption for 84 days. Subjects should consume two capsules half an hour before breakfast.
A pharmaceutical composition (A) for treating tumors comprising dendritic cells (DC) loaded with animal toxins, is new. A pharmaceutical composition (A) for treating tumors comprises dendritic cells (DC) loaded with: (i) toxins (T1), and/or associated synergists and/or antagonists, from the poison cocktail of a centipede of the genus Scolopendra, using as solvent in 15 ml of 0.9% saline solution, 7 ml of the homeopathic substance tarantula D4; and (ii) added to this mixture, up to 0.5 ml of a saturated solution of the total poison cocktail of a spider of the species Loxosceles laeta, L. gaucho, L. mallorca or L. menorca. Depending on the required ratio of component amounts, the total poison cocktail is ground in anhydrous formic acid, then1-2 ml of the total extract of poisons from bulldog ants (Myrmicinae) added, where this quantity refers to 10 ml total poison cocktail. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : The animal toxins have necrotic, cytotoxic and/or apoptotic properties.
Here, we review recent progress in the diagnosis and management of primary progressive aphasia-the language-led dementias. We pose six key unanswered questions that challenge current assumptions and highlight the unresolved difficulties that surround these diseases. How many syndromes of primary progressive aphasia are there-and is syndromic diagnosis even useful? Are these truly 'language-led' dementias? How can we diagnose (and track) primary progressive aphasia better? Can brain pathology be predicted in these diseases? What is their core pathophysiology? In addition, how can primary progressive aphasia best be treated? We propose that pathophysiological mechanisms linking proteinopathies to phenotypes may help resolve the clinical complexity of primary progressive aphasia, and may suggest novel diagnostic tools and markers and guide the deployment of effective therapies.
Glycinergic neurons regulate nociceptive and pruriceptive signaling in the spinal cord, but the identity and role of the glycine-regulated neurons are not fully known. Herein, we have characterized spinal glycine receptor alpha 3 (Glra3) subunit-expressing neurons in Glra3-Cre female and male mice. Glra3-Cre(+) neurons express Glra3, are located mainly in laminae III-VI, and respond to glycine. Chemogenetic activation of spinal Glra3-Cre(+) neurons induced biting/licking, stomping, and guarding behaviors, indicative of both a nociceptive and pruriceptive role for this population. Chemogenetic inhibition did not affect mechanical or thermal responses but reduced behaviors evoked by compound 48/80 and chloroquine, revealing a pruriceptive role for these neurons. Spinal cells activated by compound 48/80 or chloroquine express Glra3, further supporting the phenotype. Retrograde tracing revealed that spinal Glra3-Cre(+) neurons receive input from afferents associated with pain and itch, and dorsal root stimulation validated the monosynaptic input. In conclusion, these results show that spinal Glra3(+) neurons contribute to acute communication of compound 48/80- and chloroquine-induced itch in hairy skin.
The present disclosure is related to a Serjania goniocarpa methanolic extract, a plant that is found in the Yucatan peninsula. Also, the present invention is related to the different metabolites found in this plant. The extract was standardized by the content of several active compounds found in different fractions of the same. The active compounds or metabolites were isolated, purified and identified. The present invention demonstrates that the extract is useful in the preparation of a pharmaceutical composition for the cancer treatment in several modalities. This invention also demonstrates a new isolated chemical compound called goniocarpic acid, which has not been described so far. Both the methanolic extract and the new described compound have antiproliferative and cytotoxic activity being demonstrated in several tumor cell lines. These results allow establishing a new phytopharmaceutical with anticarcinogenic properties.
A computer implemented method, system, and/or computer program product create a suggested diagnostic test selection. A description of a current patient includes a current medical complaint, medical history, and physical examination result for the current patient. A cohort for the current patient is made up of persons who have a substantially similar medical complaint, medical history, and physical examination result as the current patient. Past diagnostic test sets used to make correct medical diagnoses for persons in the cohort are identified and stored in a cohort diagnostic test database. The past diagnostic test sets are sorted based on increasing levels of detrimental effects posed by each of the past diagnostic test sets. The sorted diagnostic test sets are then presented to a health care provider for the current patient.
Post-traumatic stress disorder (PTSD) is characterized by intense emotional distress upon exposure to trauma reminders and avoidance of people and places that can trigger the trauma memory. Neurocircuitry models of PTSD that seek to explain symptoms of heightened emotional reactivity, hypervigilance for threat, and avoidance suggest abnormal activity of neural regions involved in emotional reactivity (e.g., amygdala) and cognitive control of emotional responding (e.g., ventral medial prefrontal cortex, anterior cingulate cortex). While knowledge exists about neurobiological abnormalities associated with PTSD, these data are cross-sectional in nature and ignore individual differences in both neural encoding and subjective aspects of the trauma itself (e.g., whether it elicits fear vs guilt vs disgust). Additionally, the manner by which existing psychological treatments alter these neural mechanisms mediating core PTSD symptoms is unknown. This is problematic, given that state-of-the-art treatment for PTSD is only effective \~60% of the time.

Here, the investigator proposes to utilize a novel computational modeling approach combined with state-of-the-art functional magnetic resonance imaging (fMRI)-based neurofeedback to directly identify and modulate the idiosyncratic neural network encoding the trauma memory. Successful pursuit of these aims would 1) provide scientific support for the hypothesis that a distributed network including the amygdala, hippocampus, medial prefrontal cortex (PFC), lateral PFC, and anterior insula mediates emotional responding upon trauma memory recall, and 2) provide proof-of-concept evidence that neurofeedback modulation of this network can boost existing therapy efficacy.
A hair gel comprising an extract of herb medicines is provided to eliminate skin irritation, itch, and hair loss, protect hair by supplying nutrition to scalp and hair, provide gloss to the hair, be easily washed and style the hair in a desired shape. A hair gel comprises an extract of herb medicines consisting of Gelatinum, Pleuropterus multflorus, Ulmus davidiana var. japonica Nakai, Coix lachrymajobi var. mayuen, Asparagus cochinchinensis and Cervi Cornus Colla. The hair gel further comprises at least one herb medicine selected from the group consisting of ginseng, Achyranthes japonica, Akebia quinata, Dolichos lablab, Chrysanthemum indicum and Mentha arvensis var. piperascens. The hair gel further comprises 0-10 wt.% of gelatin.
BACKGROUND: Obstructive defecation syndrome (ODS) defines a disturbed defecation process frequently associated with pelvic organ prolapse (POP) in women that substantially compromises quality of life. Conservative management offers limited relief and a surgical intervention may be required. This is characterized by individual approaches. AIM OF THE STUDY: This retrospective single center study evaluated the surgical and clinical short-term outcome of a novel interdisciplinary laparoscopic resection rectopexy (L-RRP) with mesh- sacrocolpopexy (L-SCP) for women suffering from ODS and POP.
METHODS: The study participants underwent surgery in an interdisciplinary laparoscopic approach. Safety was the primary endpoint, assessed via postoperative morbidity classified by Clavien-Dindo scale. Secondary outcomes included evaluation of bowel function, fecal and urinary incontinence and pelvic organ prolapse status at 12 months follow-up. Additionally, a biological mesh (BM) was offered to women, who asked for an alternative to synthetic mesh material (SM).
RESULTS: Of the 44 consecutive patients requiring surgery for ODS and POP, 36 patients underwent the interdisciplinary surgical approach; 28 patients with SM and 8 patients with BM. In total 5 complications occurred, four of them were classified as minor. One minor complication was observed in the BM group. One anastomotic leakage occurred in the SM group. The two ODS scores, the bowel dysfunction score, and the incontinence score improved significantly (p = 0.006, p = 0.003, p < 0.001, and p = 0.0035, respectively). Pelvic floor anatomy was fully restored (POP-Q 0) for 29 (80%) patients after surgery. 17 patients (47%) suffered from urinary incontinence before surgery, which was restored in 13 patients (76.5%).
CONCLUSIONS: The interdisciplinary approach with L-RRP and L-SCP and the use of a BM in a small subgroup were technically feasible, safe, and effective in this single center setting. The study's retrospective design, the small sample size and the lack of comparators limit the generalizability of the findings requiring future randomized trials.
TRIAL REGISTRATION: Retrospectively registered at clinicaltrials.gov, trial number NCT05910021, date of registration 06/10/2023.
Women will receive vaginally one tablet misoprostol 200 mcg(Misotac; Sigma Pharma, SAE, EGYPT) plus one tablet isosorbide mononitrate 40 mg(Effox 40 mg; Minapharm). A trained clinical nurse will introduce the tablets, digitally without using speculum, 3 hours before IUD insertion into the posterior vaginal fornix of the woman while lying in the lithotomy position.
NEW MATERIAL:The beta-substituted acrylic acid p-bromophenacyl ester of formula I or formula II. USE:It has excellent antibacterial and antimycoplasmic activity and is useful as a remedy and disinfectant. It has low toxicity. PREPARATION:The compound of formula I can be prepared by reacting the beta- substituted acrylic acid of formula III with p-bromophenacyl bromide of formula IV. The reaction of the by-produced beta-substituted acrylic acid p-bromophenacyl ester or formula V with N-bromosuccinimide and methanol gives the compound of formula II. The compound of formula III can be produced from the culture product of a No.2188-producing strain (FERM-BP No.142) which is a mold belonging to Penicillium genus.
Participants will be randomized into one of three groups. In this arm, participants will perform bladder instillations using a 50ml solution of saline alone. Participants will be blinded during the study and will not know if they are receiving gentamicin or placebo (saline alone).
0.9% Sodium Chloride Injection USP is supplied sterile and nonpyrogenic in glass ampoule container.

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. Protect from freezing. It is recommended that the product be stored at room temperature (25°C); however, brief exposure up to 40°C does not adversely affect the product.

Revised: May 2018
The incretin, Glucagon-Like-peptide-1 (GLP-1) will be infused into the veins starting 30 minutes prior to initiating the GPA test. This infusion will continue for a total of 90 mins. (during the GPA for 230 mg/dL glucose levels) and then this will be stopped. The GPA test will be performed for the 340 mg/dL glucose levels but no incretin will be infused during this part of the test. These data will be compared when the subject repeats the GPA test with a placebo (saline or salt containing solution) infusion.
The study is designed as a prospective randomized control trial. Participants awaiting primary ACL reconstruction surgery were recruited at a single tertiary healthcare center between April 2016 and February 2018. An ethical approval has been given by MHH ethic committee and an IRB was involved. Due to different postoperative treatment protocols and different surgical approaches we could include participants between 13 and 46 years. A computer based randomization was performed by generating a list of randomized numbers which have been provided in sealed envelopes by an independent examiner. The postoperative treatment protocol was apart from the use of the GenuSport knee trainer identically standardized. The pain management was the same for all patients, none of the participants received a continuous peripheral nerve block. The postoperative physiotherapy protocol included gait training, assisted walking with crutches, active and passive knee mobilization, strength exercises and stair climbing. In the training group each participant was additionally provided with a GenuSport knee trainer device (prototype plus tablet with software application) with the active knee extension training program for 6 weeks. Except of that fact the postoperative protocol was identical in both groups. Participant had to train five times daily with the knee trainer starting at the day of surgery.
Good responders after sleeve gastrectomy (SG). EWL \> 50% Interventions: Gastric emptying scintigraphy and Determination of gut hormones.
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are duplexed parvovirus particles comprising the vector genome. Further disclosed are templates and methods for producing the duplexed vector genomes and duplexed parvovirus particles of the invention. Methods of administering these reagents to a cell or subject are also described. Preferably, the parvovirus capsid is an AAV capsid. It is further preferred that the vector genome comprises AAV terminal repeat sequences.
The invention discloses a hydroxyapatite-loaded ferroferric oxide nanorod and a preparation method thereof. The inventionThe prepared nano rod has a regular shape, the length of the nano rod is about 50-55nm, the width of the nano rod is close to 2 +/-0.5 nm, the nano rod has good dispersibility, and the nano rod is a magnetic nano composite material containing iron. The preparation method comprises the following steps: respectively dissolving calcium chloride and ammonium dihydrogen phosphate in ethanol and distilled water, mixing, adding oleic acid, oleylamine and prepared ferroferric oxide nanoparticles, and transferring the finally obtained mixture to an autoclave with a proper ethanol-water ratio and a polytetrafluoroethylene lining. The autoclave was placed in an oven and heated. After the reaction is finished, cooling, washing with absolute ethyl alcohol and acetone, centrifuging and dispersing in cyclohexane. In addition, use F-127 carries out surface modification on the composite material, and can endow the nano composite material with good biocompatibility. The composite material prepared by surface modification has the nuclear magnetic resonance enhancement effect and the potential of being used as a photo-thermal conversion agent.
Successful therapeutic interventions to prevent disease progression in patients with nonmetastatic osteosarcoma of pelvis and sacrum have included surgery with adjuvant chemotherapy. Pre-surgical chemotherapy has been advocated for these patients because of putative improvement in event-free survival (EFS). The advantages of pre-surgical chemotherapy include early administration of systemic chemotherapy, shrinkage of primary tumor, and pathologic identification of risk groups. The theoretic disadvantage is that it exposes a large tumor burden to marginally effective chemotherapy, especially in the axial region. The contribution of chemotherapy and surgery timing has not been tested rigorously. To study the effect of the timing of surgery on outcome of patients with nonmetastatic osteosarcoma of pelvis and sacrum, we conducted multicenter randomized trial to determine whether chemotherapy administered before definitive resection of primary tumors improved EFS and overall survival compared with traditional resection of the primary tumor followed by adjuvant chemotherapy.
Risk Summary

Data from a published clinical lactation study reports that amoxicillin is present in human milk. Published adverse effects with amoxicillin exposure in the breast-fed infant include diarrhea. There are no data on the effects of amoxicillin on milk production. Limited data suggest omeprazole may be present in human milk. There are no clinical data on the effects of omeprazole on the breast-fed infant or on milk production. There are no data on the presence of rifabutin in human milk or the effects of rifabutin on the breast-fed infant or on milk production.

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for TALICIA and any potential adverse effects on the breast-fed child from TALICIA or from the underlying condition.
Biallelic pathogenic variants in MADD lead to a very rare neurodevelopmental disorder which is phenotypically pleiotropic grossly ranging from severe neonatal hypotonia, failure to thrive, multiple organ dysfunction, and early lethality to a similar but milder phenotype with better survival. Here, we report 5 patients from 3 unrelated Egyptian families in whom 4 patients showed the severe end of the spectrum displaying neonatal respiratory distress, hypotonia and chronic diarrhea while one patient presented with the mild form displaying moderate intellectual disability and myopathy. In addition, we observed distal arthrogryposis and nonspecific structural brain anomalies in all our patients. Interestingly, cerebellar and brainstem hypoplasia were noted in one patient. Whole exome sequencing identified three novel homozygous variants in the MADD gene: two likely pathogenic [c.4321delC p.(Gln1441ArgfsTer46) and c.2620 C > T p.(Arg874Ter)] and one variant of uncertain significance (c.4307 G > A, p.Arg1436Gln). The variants segregated with the disease in all available family members. Our findings confirm that arthrogryposis, genital, cardiac and structural brain anomalies are manifestations of MADD which expand the spectrum of MADD-related neurodevelopmental disorder. Moreover, they further highlight the convergence of MADD variants on different organ systems leading to complex phenotypes.