anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
We reported that salt-sensitive hypertension (SSHTN) is associated with increased pro-inflammatory immune cells, inflammation, and inflammation-associated lymphangiogenesis in the kidneys and gonads of male and female mice. However, it is unknown whether these adverse end organ effects result from increased blood pressure (BP), elevated levels of salt, or both. We hypothesized that pharmaceutically lowering BP would not fully alleviate the renal and gonadal immune cell accumulation, inflammation, and lymphangiogenesis associated with SSHTN. SSHTN was induced in male and female C57BL6/J mice by administering nitro-L-arginine methyl ester hydrochloride (L-NAME; 0.5 mg/ml) in their drinking water for 2 weeks, followed by a 2-week washout period. Subsequently, the mice received a 3-week 4% high salt diet (SSHTN). The treatment group underwent the same SSHTN induction protocol but received hydralazine (HYD; 250 mg/L) in their drinking water during the diet phase (SSHTN+HYD). Control mice received tap water and a standard diet for 7 weeks. In addition to decreasing systolic BP, HYD treatment generally decreased pro-inflammatory immune cells and inflammation in the kidneys and gonads of SSHTN mice. Furthermore, the decrease in BP partially alleviated elevated renal and gonadal lymphatics and improved renal and gonadal function in mice with SSHTN. These data demonstrate that high systemic pressure and salt differentially act on end organ immune cells, contributing to the broader understanding of how BP and salt intake collectively shape immune responses and highlight implications for targeted therapeutic interventions.
The invention relates to a formula of a drug for treating rhinitis. The drug is a tea-bag type composite oral preparation and is utilized for treating acute and chronic rhinitis, nasosinusitis and prosopantritis. The drug for treating rhinitis comprises the following ingredients of angelica sinensis, radix astragali, rhizoma atractylodis macrocephalae, fangshui, keel, oyster, cassia twig, ligusticum wallichii, dahurian angelica root, ligusticum sinense oliver, cimicifuga foetida, flos magnoliae, monkshood, sparganium, curcuma rhizome, catnip, notopterygium root, levisticum, chrysanthemum, radix scrophulariae, radix bupleuri, cape jasmine fruit, the bulb of fritillary, xanthium, white peony root, little lotus, asarum herb, rhizoma anemarrhenae, silver flower, honey-fried licorice root, radix glehniae, poria cocos, tuber of dwarf lilyturf, root of large-flowered skullcap, gentian and mulberry leaf. Through many years of clinical application, the formula based on an ancestral "Bizutang" formula is obtained after modification. Through synergistic effects of the ingredients of the drug for treating rhinitis, the effects of tonifying qi and nourishing yin, promoting and tonifying the lung, activating blood circulation and dissipating blood stasis, clearing heat and draining dampness, reducing swelling and relieving pain, and restoring consciousness and unblocking orifices are obtained. The drug for treating rhinitis has the characteristics of obvious curative effects and convenient drug taking way.
Patients undergoing laparoscopic/robotic rectal cancer TME surgery will undergo bladder training. The bladder training include intermittent catheter clamping and active urination to facilitate complete bladder emptying each time the catheter is released, which we called ICCAUT strategy. The training will commence at 9:00 am on the first postoperative day, and the catheter will be removed at 9:00 am on the second postoperative day after the bladder is empty.
The present invention discloses a traditional Chinese medicine preparation for treating parenchyma pain. A capsule is prepared from white Longxu, sharpleaf gambirplant root, angelica tail, radix salviae miltiorrhizae, prepared fankincense, myrrh, rhizoma corydalis, radix paeoniae alba, herba lycopodli, raw Chinese ephedra, prepared rhizome of rehmannia, safflower and hemlock parsley as raw materials which are proportionally prepared according to the different characteristics of the traditional Chinese medicines. The capsule has the functions of tendon relaxation, blood circulation activation, qi replenishment, dampness elimination, meridian dredging, detumescence, pain relieving, blood stasis dispersion, dampness removal, meridian activation, wind elimination, blood stasis elimination and dispersion, tendon and muscle relaxation, spleen protection, blood replenishment, yin nourishing, channel dredging, tendon and bone strengthening, putrefaction elimination, new tissue growth, blood stasis breaking and removal, tendon reunion, channel dredging, stagnation relieving, liver regulation, tendon stretching, blood stasis activation, meridian dredging and relaxation and striae of skin, muscle and viscus warming and activation. The clinical verification shows that the capsule has an obvious therapeutic effect, and has the cure rate of 94.9% in one treatment course. The capsule is convenient and comfortable in use, is suitable for various kinds of parenchyma pain, and particularly has good therapeutic effects the limb arthromyodynia of shoulder pain, waist pain, leg pain, etc. The capsule has the advantages of reasonable formula, low preparation cost and no toxic side effect, and is convenient to transport and carry.
* Pemetrexed Injection is a cytotoxic drug. Follow applicable special handling and disposal procedures. 1
  * Calculate the dose of Pemetrexed Injection and determine the number of vials needed.
  * Inspect Pemetrexed Injection vials visually for particulate matter and discoloration prior to use. If particulate matter is observed, discard vial.
  * Withdraw the calculated dose of Pemetrexed Injection from the vial(s) and discard vial with any unused portion.
  * Dilute required dose of pemetrexed Injection, 25 mg/mL with 0.9% Sodium Chloride Injection (preservative-free) to achieve a total volume of 100 mL for intravenous infusion.
  * If not used immediately, store diluted product under refrigerated conditions [2°C to 8°C (36°F to 46°F)] for no more than 24 hours from the time of dilution. The diluted solution should be protected from light. Discard after 24 hours.
Time-restricted feeding (TRF) has recently gained popularity as a means of reducing body weight and improving glycemia. A recent clinical trial in men who had prediabetes showed that TRF for five weeks significantly reduced fasting insulin concentration and improved the derived oral glucose tolerance test ( OGTT) indexes of beta-cell responsiveness and insulin resistance. However, the effects of TRF have not been studied in patients with poorly controlled Type 2 diabetes mellitus (T2DM). In this 3-week interventional self-controlled clinical trial, the investigators hypothesize that TRF in patients with poorly-controlled T2DM can improve their mean glucose with the same dose/reduced dose of antidiabetics. Potential study subjects will be identified from Endocrinology clinic patients with a diagnosis of poorly controlled type 2 DM (A1c \>= 8.0 in the 3 months before enrollment) based on inclusion and exclusion criteria. All study subjects will be in the ad libitum feeding phase for one week, and then will be placed on time-restricted fasting (feeding between 4 AM - 4 PM, fasting in the rest of the day) for the second week. For the third and final week, patients will be returned to the ad libitum feeding phase. The first and third weeks will serve as the control phases, and the second week will be the experimental phase. The mean glucose, serum triglyceride levels, insulin resistance, and body weights will be compared between the two phases. Results of this clinical study may demonstrate a low-cost and practical way of diabetic control.
Control group: 16 treatment sessions (90 minutes in duration) either Eye movement desensitisation and reprocessing (EMDR) or Prolonged Exposure (PE) in a standard outpatient format-weekly sessions. Participants can choose to attend 6 sessions of Psychoeducation for PTSD in a group format before starting EMDR or PE.
Advances in the treatment of HIV-disease have shown dramatic effects on improving immune function in a significant proportion of people infected with HIV in the United States. For the first time since the beginning of the HIV epidemic, individuals with HIV are faced with the prospect of living longer, healthier lives. Cigarette smoking is highly prevalent among HIV+ individuals and, in addition to the negative health consequences commonly resulting from smoking, poses unique health risks to those with HIV. Our present research investigation, Positive PATHS (PATHS), the only NIH-funded smoking cessation study in HIV+ persons, is designed to evaluate a clinic-based motivational smoking cessation intervention among HIV+ smokers in Southern New England. Preliminary analysis of the PATHS investigation indicate that both a standard care intervention (brief advice and NRT) and a more extensive motivational counseling condition have similar biochemically verified smoking abstinence rates 6-months post intervention, with Latino participants responding better to the brief standard care condition. The goal of the current application is to expand upon the preliminary results of this study and target the standard care intervention to Latino HIV+ patients who were found to respond best to a brief directive approach. This expanded standard care approach will incorporate the use of culturally specific materials to provide brief advice to both the patient and a patient-identified social support person who will be trained in ways to support cessation efforts. Latinos are a population greatly affected by HIV and tobacco use, yet rarely discussed in existing research. Most tobacco research that includes Latinos has focused on prevention efforts. The few culturally specific cessation interventions that have been done have focused mostly on Mexicans in the Southwest and California1,2,3. Considering the diversity of the Latino population in the US, those interventions may not generalize to Latinos in the Northeast, who are mostly of Puerto Rican and Dominican origin. Research is limited in the area of HIV among Latinos and there are no studies to date that address the problem of tobacco use among HIV+ Latinos. We propose to address this disparity by focusing this particular research study on Latino men and women living with HIV/AIDS.
A depilatory comprises a mercaptan combined with a chemically equivalent amount of a base having an ionisation constant sufficient to give effective depilatory action to the mercaptan, and a free organic base.  The preferred base is guanidine and the preferred mercaptan is thioglycollic acid.  The depilatory may be in pre-emulsion form or an aqueous emulsion.  Anionic emulsifying agents which may be used are salts of sulphated fatty alcohols, but non-ionic agents are preferred.  Fat or wax-like bodies may be added, e.g., sorbitan monostearate plus polyoxyalkylene sorbitan monostearate; and borax plus beeswax with polyoxyalkylene sorbitan monostearate.  Hydrated alumina, water soluble or dispersible polyvinyl alcohol, starch tetra acetate, sodium starch glycollate, bentonite, alginates, cellulose ethers or the sodium salt of carboxy methyl amylopectin and cellulose esters.  Bile acid salts, hydrazine sulphate, hexamethylene di-isocyanate, other di- or tri-isocyanates or n-propenyl allophanate may be added and also wetting agents such as the sulphated or sulphonated compounds of alkylnaphthalenes or dibasic acid esters, sulphated or sulphonated amides, polymerised polyglycol esters and fatty acid amide derivatives.  Specification 593,438 is referred to.
The invention provides a system and method for remote layout control of a medical image viewer. The invention provides a layout control computing device. The computing device includes a processor programmed to display a control user interface via a first display screen and a display user interface via a second display screen. The control user interface includes a layout template having a plurality of tiles, each tile having an indicator of a rendered view. The display user interface includes a plurality of viewports arranged according to a layout template, and each viewport is configured to display the medical image in a rendered view as indicated by an indicator of a corresponding tile. The processor is also programmed to receive a command to move the first tile to a location of the second tile, update the layout template, direct the layout of the viewport in accordance with the updated layout template, and direct the display of the image in the viewport in a rendered view as indicated in the updated layout template.
INTRODUCTION: Data from different countries show partly controversial impact of SARS-CoV-2 infection on pregnancy outcomes. A nationwide register-based study was conducted in Estonia to assess the impact of SARS-CoV-2 infection at any time during pregnancy on stillbirth, perinatal mortality, Apgar score at 5 minutes, cesarean section rates, rates of preterm birth and preeclampsia.
MATERIAL AND METHODS: Data on all newborns and their mothers were obtained from the Estonian Medical Birth Registry, and data on SARS-CoV-2 testing dates, test results and vaccination dates against SARS-CoV-2 from the Estonian Health Information System. Altogether, 26 211 births in 2020 and 2021 in Estonia were included. All analyses were performed per newborn. Odds ratios with 95% confidence intervals (CI) were analyzed for all outcomes, adjusted for mother's place of residence, body mass index, age of mother at delivery and hypertension and for all the aforementioned variables together with mother's vaccination status using data from 2021 when vaccinations against SARS-CoV-2 became available. For studying the effect of a positive SARS-CoV-2 test during pregnancy on preeclampsia, hypertension was omitted from the models to avoid overadjustment.
RESULTS: SARS-CoV-2 infection during pregnancy was associated with an increased risk of stillbirth (adjusted odds ratio [aOR] 2.81; 95% CI 1.37-5.74) and perinatal mortality (aOR 2.34; 95% CI 1.20-4.56) but not with a lower Apgar score at 5 minutes, higher risk of cesarean section, preeclampsia or preterm birth. Vaccination slightly decreased the impact of SARS-CoV-2 infection during pregnancy on perinatal mortality.
CONCLUSIONS: A positive SARS-CoV-2 test during pregnancy was associated with higher rates of stillbirth and perinatal mortality in Estonia but was not associated with change in preeclampsia, cesarean section or preterm birth rates.
Overweight and obesity are increasing global health problems and the most important contributors to morbidity and mortality. Obesity (abdominal obesity), together with hyperglycemia, dyslipidemia and hypertension forms a cluster of risk factors that is called the metabolic syndrome (MetS). The first-line therapy for MetS is lifestyle intervention - education on a healthy lifestyle leading to a focus on physical activity and diet, which will improve risk factors closely linked to MetS. The maintenance of long-term weight loss is difficult, and individuals often regain weight after an intervention program stops. It is of interest to find ways to prevent and alleviate MetS, beyond the known effects of lifestyle modification and weight loss. Fish has been proposed as a food that may have favorable effects on metabolic health. Previous intervention studies with fish protein in humans and rodents have shown improved insulin sensitivity and glucose tolerance, reduced cholesterol levels in plasma and reduced blood pressure. Intervention studies investigating the effect of cod have mainly focused on the health effect of consuming the whole fillet. Studies on the remaining part of the fish, the residual material, primarily used for production of animal feed, are scarce. There is evidence that cod, and other marine fish, may contain bioactive peptides that have potentially important health effects in humans. Therefore, it is of interest to investigate the possible effect of a daily supplement of marine protein hydrolysate (MPH), taken over a longer period, in a group of patients with abnormal glucose control. The aim of this study is to investigate the effect of adding a MPH supplement to the diet over an 8-week period in a group of adults with established MetS. The investigators expect that supplementation with MPH will lead to beneficial changes in the components of MetS and an overall healthier metabolic profile.
The CI group will receive a 60-minute conventional stroke rehabilitation training followed by a 30-minute functional training. During the 60-mimute conventional training, interventions will include passive range of movement and muscle tone normalization techniques of the affected arm, and gross motor training (e.g., shoulder ladder activity), fine motor training (e.g., grasping cones), and muscle strength training in a unilateral and bilateral manners. During the 30-minute functional training, the same principles to those in the MT groups will be applied.
The invention provides an improved chew toy for delivering nutrients to pets. More particularly, the invention comprises rawhide having a coating or baste comprising at least one nutriceutical substance. In one aspect of the invention, the nutriceutical substance is Echinacea purpurea. In another aspect of the invention, the nutriceutical substance is glucosamine HCL. In another aspect of the invention, the nutriceutical substance is Vitamin A. In another aspect of the invention, the nutriceutical substance is calcium.
Patients will undergo dose escalated five fraction stereotactic radiosurgery for diagnosed brain metastases. Tumors must fall into one of two categories: 2.1-4.0cm diameter or 4.1-6.0 cm diameter. Only single largest tumor will be treated with dose escalation. All other tumors (if present) will be treated with standard of care five fraction stereotactic radiosurgery.
PURPOSE:To provide the titled vesicles, by treating animal erythrocyte with a hypotonic solution, fragmentizing the obtained ghost membrane of erythrocyte, and leaving the fragment in an isotonic solution at the temperature of living body to effect the conversion to the vesicle. CONSTITUTION:Animal erythrocytes are washed, and hemolyzed by treating with a hypotonic solution (e.g. hypotonic tris-buffer solution) to obtain ghost membrane of erythrocyte free from hemoglobin and other cytoplasms. The membrane is dispersed in an isotonic solution and fragmentized with shearing force (e.g. ultrasonic irradiation). The concentration of the ghost membrane in the isotonic solution is preferably 0.1-10wt%. The isotonic solution dispersed with the ghost membrane is left at rest for a definite period (e.g. 30-120min) at a definite living body temperature (e.g. 37 deg.C) to obtain vesicles composed of the fragment of erythrocyte ghost membrane. The diameter of the vesicle can be made smaller than that of the capillary vessel, and the vesicle is excellent from the medical viewpoint.
PURPOSE:To improve the impact resistance and storage stability of a solid pharmaceutical, by applying a sugar coating solution contaiing pullulan in an aqueous solution of sucrose to carry out the sugar coating of the solid pharmaceutical. CONSTITUTION:Pullulan or a water-soluble derivative thereof, e.g. pullulan ester or ether, is added to an aqueous solution of sucrose to prepare a sugar coating solution containing 30-80wt%, preferably 40-70wt% sucrose and 0.1- 10wt%, preferably 0.5-5.0wt% pullulan, and a dyestuff, binder, masking agent, etc. are added if necessary thereto. The resultant coating solution is then used to apply a sugar coating to a tablet, pill, granule or fine granule, etc. The resultant solid pharmaceutical keeps almost the same disintegration property as that just after the production thereof with little browning even in storing under severe conditions.
Recent evidence indicates that the carboxy-terminal region of the tumor suppressor protein BRCA1 is a functionally significant domain. Using the yeast two-hybrid assay and an in vitro biochemical assay, it is here shown that a protein, B112, interacts specifically with the carboxy-terminal segment of human BRCA1 from residue 1602 to 1863. A germ line truncation mutation, 1853ter, that removes the last 11 amino acids from the carboxy-terminus of BRCA1 abolishes not only the transcription activation function, but also binding to B112. The B112 protein is apparently the same as an uncharacterized protein known as CtIP, the sequence of which was previously deposited in GenBank. Screenings of a panel of 92 tumor cell lines for mutations in the B112/CtIP sequence have identified a number of missense variants, including a non-conserved lysine to glutamic acid change at codon 337 in the pancreatic cancer line, BxPC3. Taken together, these results indicate that B112/CtIP participates in a common biochemical pathway as BRCA1 and that the interaction of these two proteins may be required for the tumor suppressor function of BRCA1.
PURPOSE:To obtain the cyclodextrin clathrate compound of suloctidil having peripheral vessel dilating activity, lipid metabolism improving activity, etc. and improved solubility, stability and bitter taste. CONSTITUTION:Suloctidil of formula[chemical name: erythro-1-(p-isopropylthiophenyl)-2-octylaminopropanol]is added to a saturated solution of cyclodextrin singly or in the form of a solution in a water-miscible organic solvent, e.g. methanol, ethanol, etc., and stirred at 10-90 deg.C, preferably 20-60 deg.Cfor 4-24hr to obtain the objective clathrate compound as precipitate. The amount of suloctidil is selected to match with the inclusion ratio to cyclodextrin, preferably 0.05- 0.5mol per 1mol of cyclodextrin. EFFECT:The characteristic bitter taste of suloctidil can be eliminated, and the light-stability is improved.
Polyene macrolide has a notable antifungal effect structurally characterized by the fact that it has a lactone ring in the free carboxyl group and a primary amino group of aminosugar. This is produced by esterifying the carboxyl group, which leads to basic compounds that are no longer amphoteric. The substance was amphoteric to begin with. In the formulation of the esters there are radicals that assure a rapid hydrolysis. This can be because of the actions of various non-specific esterases, or because of the simple chemical division. The reactions that had operational characteristics and caused notable chemical loosening of the macrolide molecules were used. The fungal activities of the polyenic antibiotics are maintained by the derivatives attained, or be it their salts. While these antibiotics are practically insoluble, the salts that are derived from them have a good solubility level in water, with a pH close to neutral, and a product quality that has a high activity level.