anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Fabry disease is a recessively inherited disorder due to systemic storage of abnormal metabolites (ceramide trihexocide, in particular) caused by lack of the lysosomal enzyme α-galactosidase. Though X-linked, in patient series there are often equal numbers of males (hemizygotes ) and females (heterozygotes, probably caused by a mutation in one allele and an inactivation on the other allele in the X chromosomes), and many clinical features are shared (Cox 2005).

Abnormal storage in endothelial and smooth muscle cells explains morbidity, including a shortened life expectancy (Frost \& Tanaka 1966; Desnick et al. 1976; deVeber et al.1992; Hughes \& Mehta 2005; Nguyen et al. 2005; Sodi et al. 2007). This is due to age dependent ischaemic manifestations that affect heart, kidney and brain. Angiofibroma is an early cutaneous manifestation, and painful acro-paresthesias express juvenile neuropathy (Cox 2005; Cleary et al. 2005).

Cornea verticillata is an almost obligate ophthalmic finding. The brown-yellow Bowman membrane related corneal deposits and teleangiectatic conjunctival vessels are early ophthalmic slit-lamp markers of the disorder; further there can be subtle lens opacities. Fundus vessel tortuosity is observed in many patients, in particular of the retinal venules, but best corrected visual acuity (BCVA) is usually normal (Ballantyne \& Michaelson 1970; Lou et al. 1970; Sher et al. 1979; Utsumi et al. 2009).

After the introduction of enzyme substitution therapy in 2001, ophthalmic examinations were scheduled as regular part of the general evaluation of the Fabry patients at Rigshospitalet, Denmark. A 10-year ophthalmic state of arts was part of oral presentations at a Copenhagen conference in December 2011. In contrast to the common occurrence of systemic vascular sequels, only one patient in the series had suffered severe visual loss; this was unilateral and occurred years before institution of the enzyme therapy (Andersen et al. 1994). In 2013, however, another young male presented a similar retinal event. Sporadic cases of visual loss are reported in the literature (Sher et al. 1978,1979; Tuupurainen et al. 1981; Sakkuraba et al. 1986; Utsumi et al. 2009), but in larger Fabry series ocular vascular catastrophes appear the exception to the rule (Orssaud et al. 2003; Hughes \& Mehta 2005; Nguyen et al. 2005; Sodi et al. 2007; Utsumi et al. 2009)).

Following the introduction of enzyme substitution, we found it of interest to present our nationwide Danish experience. We focused on retinal vessel morphology and the relation to systemic morbidity.
PURPOSE: To obtain an aerosol-supplying device to supply a seasoning agent or a drug by a non-combustion low-temperature heat source generated by the exothermic reaction of chemical reagents. CONSTITUTION: This aerosol-supplying device is composed of (A) a seasoning agent or a drug and (B) a non-combustion heat source for the heating of the seasoning agent or the drug, physically separated from the seasoning agent or the drug and containing the 1st agent (e.g. Mg or Al) causing exothermic reaction with a 2nd agent (e.g. water), a 3rd agent (e.g. NaOH) causing exothermic reaction with the 1st agent and a dispersing agent (e.g. NaCl) for the 1st agent. At least a part of the seasoning agent or the drug is heated up to 70-350 deg.C by the heat source within 20sec after starting the exothermic reaction. The heat source preferably further contain a phase-changing agent or a heat- exchanging agent. The dispersing agent and the phase-changing agent are solid under normal condition.
A clinical, evidence-based model to inform clients and their parents about the nature of stuttering is indispensable for the field. In this paper, we propose the Erasmus Clinical Model of Stuttering 2.0 for children who stutter and their parents, and adult clients. It provides an up-to-date, clinical model summary of current insights into the genetic, neurological, motoric, linguistic, sensory, temperamental, psychological and social factors (be it causal, eliciting, or maintaining) related to stuttering. First a review is presented of current insights in these factors, and of six scientific theories or models that have inspired the development of our current clinical model. Following this, we will propose the model, which has proven to be useful in clinical practice. The proposed Erasmus Clinical Model of Stuttering visualizes the onset and course of stuttering, and includes scales for stuttering severity and impact, to be completed by the (parent of) the person who stutters. The pathway of the model towards stuttering onset is based on predisposing and mediating factors. In most children with an onset of stuttering, stuttering is transient, but if stuttering continues, its severity and impact vary widely. The model includes the circle of Engel (1977), which visualizes unique interactions of relevant biological, psychological, and social factors that determine the speaker's experience of stuttering severity and its impact. Discussing these factors and their interaction with an individual client can feed into therapeutic targets. The model is supplemented by a lifeline casus.
No metformin during primary endpoint assessment period (at least 3 weeks). Patients will subsequently be initiated on metformin.
<P>PROBLEM TO BE SOLVED: To provide a plaster whose separation liners are easily separated, and whose parts of a healing ointment layer are prevented from sticking together when the plaster is stuck to skin and also made to be thin on the whole and uniform, is excellently stuck to the skin, follows the skin, and prevents creases from being gathered even when the plaster is stuck to a bent part, and to provide a device for efficiently producing the plasters and its method.  <P>SOLUTION: The healing ointment layer 20 is formed on the upper surface of a support body 10, and separation materials 30 are superimposed on the upper surface of the healing ointment layer 20 in the plaster 1. The support body 10 is a skin-following type thin layer film. The separation materials 30 consist of a pair of separation liners 31, 32. One separation liner 31 is superimposed on part of the healing ointment layer 20, and the other separation liner 32 is superimposed on the rest part of the layer 20. A superimposition area 34 is formed at the inner end edge part of the other separation liner 32. The rear surface of the superimposition area 34 is overlapped with an inner end edge part on the front surface of the separation liner 31.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
The invention relates to camel blood polypeptide with a blood sugar reducing function and a preparation method thereof. The method takes camel blood as a raw material, and the camel blood enzymolysis liquid is obtained through enzymolysis and filtration. Adsorbing by using an ion exchange resin column, eluting by using 0.1-5% ammonia water, separating by using a chromatographic column, and drying to obtain the purified camel blood polypeptide with the blood sugar reducing function. The content of the prepared camel blood polypeptide product is more than 90 percent, and the recovery rate is more than 70 percent. Compared with the prior art, the invention is characterized in that the invention provides a preparation process for preparing camel blood polypeptide with the function of reducing blood sugar by using camel blood; the whole production process uses a green solvent, and has the advantages of low cost, high efficiency, environmental friendliness, simple process route and the like. The camel blood polypeptide can provide high-purity camel blood polypeptide with the function of reducing blood sugar for medicines, health products or foods and the like, and can further promote the industrial development of camels.
Comprehensive physical therapy intervention in small groups (3 members), altogether 16 sessions were performed during a period of 8 weeks (twice a week). Each session lasted 1 hour.
OBJECTIVE: To evaluate the combined impact of videofluoroscopic swallow study (VFSS) and therapeutic feeding and swallowing interventions on clinical outcomes in children with oropharyngeal dysphagia (OPD).
METHODS: This was an uncontrolled longitudinal analytical study in which OPD patients were evaluated before and after VFSS. Children ≤ 24 months of age diagnosed with OPD in a clinical setting and undergoing VFSS for investigation and management of OPD were included in the study. The study participants received therapeutic feeding and swallowing interventions after having undergone VFSS, being followed at an outpatient clinic for pediatric dysphagia in order to monitor feeding and swallowing difficulties. Respiratory and feeding outcomes were compared before and after VFSS.
RESULTS: Penetration/aspiration events were observed in 61% of the VFSSs (n = 72), and therapeutic feeding and swallowing interventions were recommended for 97% of the study participants. After the VFSS, there was a reduction in the odds of receiving antibiotic therapy (OR = 0.007) and in the duration of antibiotic therapy (p = 0.014), as well as in the odds of being admitted to hospital (p = 0.024) and in the length of hospital stay (p = 0.025). A combination of oral and enteral feeding became more common than oral or enteral feeding alone (p = 0.002).
CONCLUSIONS: A high proportion of participants exhibited penetration/aspiration on VFSS. Therapeutic feeding and swallowing interventions following a VFSS appear to be associated with reduced respiratory morbidity in this population.
Each subject will wear the 1-day toric test (Test) lens in one eye and 1-day toric control (Control) contact lens in the other eye. Patient will wear as an unmatched pair, per predetermined randomization schedule (to determine which eye receives the Test or Control contact lens).
Participants received an initial dose of mycophenolate mofetil (MMF), 1 gram (g), orally (PO), twice per day (BID), within 5 days of transplant for 24 weeks. Participants also received concurrent antibody induction, cyclosporine, and corticosteroids as needed according to center's practice.
PURPOSE OF REVIEW: The purpose of this review is to investigate the long-term outcomes of cancer patients who experience sepsis or septic shock.
RECENT FINDINGS: Sepsis is a frequent cause of ICU admission in cancer patients, accounting for approximately 15% of such cases. Short-term mortality rates among these patients vary widely across studies, but they are consistently found to be slightly higher than those of noncancer patients. However, there is a lack of evidence regarding the long-term outcomes of cancer patients who have experienced sepsis or septic shock. The few available studies have reported relatively high mortality rates, reaching around 80% in a few cohort studies. Although several observational studies have noted a decrease in 1-year mortality rates over time, observational data also suggest that sepsis may increase the risk of cancer in the long run.
SUMMARY: As cancer is becoming a chronic disease, there is an urgent need for studies on the quality of life of cancer patients who have experienced sepsis. The relationship between sepsis and cancer extends beyond its impact on the progression of cancer, as sepsis might also contribute to the development of cancer.
OBJECTIVES: This study compares the follow-up rates of non-normal cervical screening samples between Denmark and Flanders (Belgium) to illuminate whether organizational differences between the health systems might affect the follow-up rates, e.g. sending of reminders in Denmark since 2012 compared to Flanders with no such system in place.
METHODS: The study population included 48,082 Danish women and 22,271 Flemish women who received abnormal or inadequate primary screening results from 2014 to 2016. The participants were followed for 24 months, and the timeliness and appropriateness of the recommended follow-up, according to national guidelines, were evaluated.
RESULTS: After 18 months over 90% of the Danish women had received some form of follow-up, while in Flanders, this level is achieved only for those who test positive for human papillomavirus. The analysis also revealed that 10-28% of follow-ups were performed too early, with Danish women showing the highest proportions. In both regions, general practitioners (GPs) exhibited better follow-up rates compared to gynaecologists, with gynaecologists displaying a tendency towards earlier re-testing than recommended.
CONCLUSIONS: An important factor influencing the follow-up rate may be the sending of reminders in Denmark since 2012, as the follow-up rates in general were higher in this period. It is noteworthy that a reminder system is currently being implemented in Flanders and further studies on the potential effects should be studied. Additionally, the organization of the health system might influence the follow-up rate, as engaging the GP for screening in Denmark may have had a positive effect.
INTRODUCTION: Septic shock is a severe form of sepsis that has a high mortality rate, and a substantial proportion of these patients will develop cardiac dysfunction, often termed septic cardiomyopathy (SCM). Some SCM patients may develop frank cardiac failure, termed sepsis-related cardiogenic shock (SeRCS). Little is known of SeRCS. This study describes baseline characteristics of patients with SCM and SeRCS compared to patients with septic shock without cardiac dysfunction. We compare clinical outcomes among SCM, SeRCS, and septic shock, and identify risk factors for the development of SCM and SeRCS.
METHODS: Septic patients admitted to the ICU with an echocardiogram obtained within 72 hours were included. Left ventricular ejection fraction of ≤55% was used to define SCM, and cardiac index ≤2.1 L/min/m2 among patients with SCM defined SeRCS. Machine learning was used to identify risk factors for development of SCM and SeRCS. Logistic regression was used to compare mortality among groups.
RESULTS: Among 1229 patients, 977 patients had septic shock without cardiac dysfunction, 207 had SCM, and 45 had SeRCS. In patients with septic shock, the strongest predictor for developing SCM and SeRCs was a prior history of cardiac dysfunction. Mortality did not significantly differ among the three groups.
CONCLUSIONS: SCM and SeRCS affect a minority of patients with septic shock, disproportionately affecting individuals with a history of cardiac disease. We did not identify a mortality difference associated with SCM or SeRCS. Additional work is needed to define further subtypes and treatment options for this patient population.
INTRODUCTION: Stroke is a common cause of disability and death in adults, with spasticity being a common post-stroke complication that can significantly affect patients' quality of life. This study aimed to investigate the impact of exercise therapy alone versus exercise therapy combined with dry needling on clinical outcomes in patients with chronic spasticity after stroke.
METHODS: Forty patients were randomly assigned to either a control or intervention group. The control group received a standard exercise program consisting of two sessions per week for six weeks. The intervention group received the same exercise program in addition to dry needling of the hip and leg muscles. Clinical outcomes were assessed using the Modified Modified Ashworth Scale, Timed Up & Go Test, and goniometer in four separate examination sessions.
RESULTS: The findings of this study suggest that the addition of dry needling to exercise therapy led to faster and longer-lasting improvements in clinical outcomes. The intervention group showed significant improvements in spasticity, range of motion, and function in the second through fourth examination sessions, while the control group's improvements decreased over time. Between-group comparisons revealed significantly greater improvements in the intervention group than the control group.
CONCLUSIONS: The findings suggest that combining dry needling with exercise therapy may be beneficial in managing post-stroke spasticity. Dry needling may lead to faster and more significant improvements in clinical outcomes, ultimately improving function and quality of life for patients with chronic spasticity after stroke.
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is a sigmoidal release. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt. The osmotic device further includes a drug-containing coat external to the semipermeable membrane. The osmotic device can include one or more additional drugs in the core and/or the drug-containing coat.
BACKGROUND: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region.
METHODS: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis.
DISCUSSION: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia.
Subjects will consume two cow's milk drinks from the content of 2 sachets (40 g cow's milk protein, casein, and 600 mg calcium) in place of a small meal, five days per week. Each sachet will contain 20 g cow's milk protein and 300 mg calcium. Content of sachets will be mixed with \~1.6 liter of water for ingestion. Casein is free of ovarian hormones.
The present invention relates to a pure traditional Chinese medicine, namely an externally applied preparation for removing dampness and relieving osteodynia. The externally applied preparation adopts 2 to 15% of propolis and 0.5 to 5% of camphor as the main active ingredients. The preparation can be various conventional forms, preferably liniment. The liniment is basically prepared from 2 to 15% of propolis, 0.5 to 5% of camphor and a polar solvent, preferably alcohol, and more preferably alcohol of 96%(v/v), as the rest. The externally applied preparation has an obvious therapeutic effect, and is very convenient for use by spreading at an affected part only. Through a good deal of clinical experiments, the preparation has an obvious therapeutic effect on sinew and bone pain caused by rheumatism, rheumatoid arthritis, arthrocele and various pains in shoulders, loins and legs, including periarthritis of shoulders, cervical syndrome, rigid and hyperplasic spondylitis, tennis elbow, sciatica, spinal stenosis, lumbar muscle strain, numbness of limbs, etc., disturbing people. The cure rate of the preparation can achieve more than 85%, and the preparation does not have any toxic or side effects.
Multiple Sclerosis (MS) is a chronic, degenerative disease of the central nervous system, characterized by inflammatory demyelination and axonal degeneration. MS affects approximately 1 in 500 Canadians. There is no cure for MS and the heterogeneous symptoms of the disease makes it difficult to prescribe effective treatment strategies for disease management. While the progression, severity and specific symptom profile vary from person to person, there are three key symptoms associated with brain health- fatigue, depression and cognitive impairment- that invariably lead to poor quality of life and increased health care costs. Unfortunately, the majority of people with MS suffer from these symptoms (fatigue affects \~90%, depression affects \~50% and cognitive impairment affects 40-65%) and a critical challenge with MS is that these symptoms do not present individually. For example, persons with MS who experience depression are more likely to also experience fatigue and/or cognitive impairment, which together may be more detrimental to quality of life than each symptom alone.

New evidence suggests that the three symptoms affecting brain health may be interrelated through a common mechanism of inflammation. Further, physical exercise is known to reduce inflammation and thus is a prime candidate for a novel therapeutic approach to symptom management through its effect on modulating the inflammatory response. Indeed, physical activity is already used to improve the physical status of individuals with MS and evidence-based physical activity guidelines (PAGs) for MS have been developed to guide prescription. However, the guidelines have not been tested for their effects on reducing inflammation and brain health disease systems. Therefore, the proposed research will be the first to evaluate the clinical utility of the PAGs for MS in reducing brain health disease symptoms and improving quality of life, and the first to comprehensively determine the putative effects of inflammation on these symptoms.
Tongue depressor exercise protocol for tongue strengthening for control group. Using the tongue depressor, participants will be prompted to stick their tongue out as much as they can and to push hard against the tongue depressor for 10 seconds. They will be required to repeat this action 10 times, constituting one set. They will be asked to perform 3 sets, with 30 secs of rest between each set. Arrange for 5 sessions for a week; sessions can take place on consecutive days.