anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Therapy plans performed at home overseen by a remote physical therapist via SimpleTherapy. Allocation to this group will require using smart devices or a computer/laptop to receive care. Remote visits with a PT typically last 45min long and home exercises suggested by the app are self-paced.
Integrative interventional programme. It involves high-frequency multidisciplinary intervention: nursing, psychology, psychiatry and social services. A psychotherapeutic group would be offered to those patients with an intelligence quotient\>70, verbal communication and no behavioural alterations.
Illustrated Patient's Instructions for Use accompany each package of budesonide inhalation suspension.

Budesonide inhalation suspension, 0.25 mg/2 mL is supplied in a sealed aluminum foil envelope containing one plastic strip of five single-dose vials. Each single-dose vial contains 2 mL of sterile liquid suspension, supplied in unit-dose cartons of 30 vials (6 pouches × 5 vials). 

Budesonide inhalation suspension, 0.5 mg/2 mL is supplied in a sealed aluminum foil envelope containing one plastic strip of five single-dose vials. Each single-dose vial contains 2 mL of sterile liquid suspension, supplied in unit-dose cartons of 30 vials (6 pouches × 5 vials). 

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Store upright and protect from light.

When an envelope has been opened, the shelf life of the unused vials is 2 weeks when protected. After opening the aluminum foil envelope, the unused vials should be returned to the aluminum foil envelope to protect them from light. Any opened vial must be used promptly. Gently shake the vial using a circular motion before use. 

Keep out of reach of children. Do not freeze.
FIELD: production of medicinal preparations. SUBSTANCE: animal raw material is ground, then extracted in acetic acid solution at room temperature at periodical stirring during 18-24 hours. Then the raw material is poured into tanks and is subjected to single-time freezing at 5 to 20 deg C below zero temperature. Then the raw material is defrosted. After defrosting is finished completely, content of tanks is filtered through capron grid, lightened and subjected to ultrafiltration through membranes which have transmission threshold of 10 kD. Ultrafiltrate is dissolved by distillate water till achieving required content of peptides and medicinal preparation is prepared. Yield of end production increased 5-8 times from unit of raw material. EFFECT: improved efficiency.
The Contest only group were eligible to receive the financial incentives for weight loss maintenance for maintaining weight lost at three monthly follow ups; weeks 16, 20 and 24. Eligible participants completed online surveys and in person weigh ins verifying weight maintenance.
An intelligent admittance device comprises a voice prompt unit, a dosage monitoring unit and an information transmission unit. The processing module can judge whether the inhaled quantity reaches the effective medicine dose according to the medicine inhaled dose value collected by the dose monitoring unit arranged in the administration channel. The processing module can also selectively output different prompt instructions according to the monitoring result. The voice prompt unit sends out different medication guidance prompts according to the received instructions. The voice prompt unit at least stores three voice prompt modes, and can also send out voice prompts according to the set prompt mode actively selected by the patient, so that the patient can take medicine according to the prompt instruction. The invention can prompt the patient to take medicine on time, guide the patient to take medicine correctly, quantitatively and sufficiently, improve the medication compliance of the patient, establish high-quality big data of patient medication tracking, promote the health of the patient and provide a new practical basis for clinically promoting the health of the patient.
BACKGROUND: This study aimed to clarify the effects of exercise-based cardiac rehabilitation (CR) on patients with heart failure.
METHODS AND RESULTS: Patients were divided into groups according to intervention duration (<6 and ≥6 months). We searched for studies published up to July 2023 in Embase, MEDLINE, PubMed, and the Cochrane Library, without limitations on data, language, or publication status. We included randomized controlled trials comparing the efficacy of CR and usual care on mortality, prehospitalization, peak oxygen uptake (V̇O2), and quality of life. Seventy-two studies involving 8,495 patients were included in this review. It was found that CR reduced the risk of rehospitalization for any cause (risk ratio [RR] 0.80; 95% confidence interval [CI] 0.70-0.92) and for heart failure (RR 0.88; 95% CI 0.78-1.00). Furthermore, CR was found to improve exercise tolerance (measured by peak V̇O2and the 6-min walk test) and quality of life. A subanalysis performed based on intervention duration (<6 and ≥6 months) revealed a similar trend.
CONCLUSIONS: Our meta-analysis showed that although CR does not reduce mortality, it is effective in reducing rehospitalization rates and improving exercise tolerance and quality of life, regardless of the intervention duration.
Participants will be submitted to individual and structured physiotherapy sessions (the same as the control groups). They will also participate in a structured mental practice session (lasting 30 minutes and three times a week), totaling 12 sessions at the end of this intervention.
PURPOSE: A pharmaceutical composition containing raloxifene and pharmaceutically acceptable salt thereof is provided to improve body absorption rate. CONSTITUTION: A pharmaceutical composition contains raloxifene with improved elution rate or pharmaceutically acceptable salt thereof; and caprylocaproyl macrogolglyceride. The composition additionally contains soluble saccharide or excipient. The excipient is lactose. The composition also contains an adsorber. A method for manufacturing the pharmaceutical composition comprises: a step of preparing a binding solution containing raloxifene or pharmaceutically acceptable salt thereof, and carprylocaproyl macrogolglyceride; a step of mixing microcrystalline cellulose, lactose, or excipient of mixture thereof, and adsorber; and a step of granulating the mixture and binding solution.
Automated insulin delivery (AID) technologies hold the promise of optimizing glycemic control and reducing the burden of diabetes care for patients with Type 1 Diabetes (T1D). However, clinical trials of lower burden AID technologies have not included older adults in sufficient numbers to allow for focused evaluation of efficacy and quality of life (QOL) impacts that may differ from those observed in younger age groups. Most notably, primary endpoints have focused on reducing hyperglycemia, while avoidance of hypoglycemia is of upmost concern for older adults with T1D. T1D Exchange clinic registry data have shown severe hypoglycemia (SH) occurs more commonly in older adults with longstanding T1D than in younger individuals with events occurring just as often with HbA1c levels \>8.0% as with HbA1c levels \<7.0%. These data do not support the strategy of "raising the HbA1c" as being an effective approach for hypoglycemia prevention in older adults with T1D. In addition to acutely altered mental status, hypoglycemia is associated with an increased risk for falls leading to fractures, car accidents, emergency room (ER) visits, hospitalizations, and mortality resulting in substantial societal costs. The occurrence of hypoglycemia, hypoglycemia unawareness and fear of hypoglycemia have adverse effects on overall QOL of both individuals with T1D and their families.

While continuous glucose monitoring (CGM) technology alone has the potential to be beneficial in reducing hypoglycemia in older patients, our preliminary data from the Wireless Innovations for Seniors with Diabetes Mellitus (WISDM) trial shows a majority of patients still have frequent hypoglycemia even when using CGM. Thus, knowledge of CGM alone may not be sufficient to avoid hypoglycemia in this population. Predictive low-glucose suspend algorithms have particular promise when the primary goal is hypoglycemia avoidance rather than glucose reduction. Whether the added complexity of closed loop systems provides additional glycemic benefit is not known. There is a critical need to determine whether automated insulin delivery can reduce hypoglycemia in the older adult population with T1D.
531,224. Vitamin E. GENERAL MILLS. Inc. July 14, 1939, No. 20566. Convention date, Sept. 24, 1938. [Class 2 (iii)] For producing a concentrate of vitamin E and anti-oxidant, wheat germ oil is hydrogenated and extracted with an alcohol such as methyl, ethyl or propyl alcohol, the alcoholic extract being cooled to remove sterols and glycerides; the alcohol is then distilled off and the residue if desired may be further concentrated by saponification and extraction. In an example wheat germ oil is hydrogenated with palladium chloride and after filtering off the catalyst is extracted with methanol vapour, the methanol extract being cooled to separate sterols and evaporated to dryness. In another example the hydrogenation is effected with nickel on diatomaceous earth and after separating the catalyst the oil is shaken with hot methanol in a separating funnel, the extract being cooled to separate sterols and evaporated as before. Any odour may be removed by treatment with steam in a vacuum. Alternatively the hydrogenation may be effected continuously.
Prepn. of alkaloids I, II and III from Pentadiplandra brazzeana, by 95% ethanolic extraction of the dried root. The alkaloids have unspecified uses in industry and as drugs. The individual alkaloids are isolated by chromatography or by solvent fractionation. Alkaloid I is extracted from the concentrated ethanolic extract with light petroleum. The residual phase, when treated with CHCl3 and alkali gives II when the CHCl3 is evaporated. Alkaloid III remains in the phase after sepn of the CHCl3 extract.
The investigators are undertaking a parallel group, multicenter, randomized controlled trial of 120 steroid-resistant/relapsed ITP adult patients from 6 medical centers in China. One part of the participants are randomly selected to receive recombinant human thrombopoietin (given subcutaneously at a dose of 300 Units/kg for 14 consecutive days, following with a flexible dosage depending on platelet count until the 29th day), combining with cyclosporin A (given orally at a dose of 1.5-2.0mg/kg twice daily for 3 consecutive months, adjusted to maintain serum levels between 200-400 ng/ml and tapered by 50 mg/d per week if patients achieved a complete response). The others are selected to receive cyclosporin A monotherapy (given orally at a dose of 1.5-2.0mg/kg twice daily for 3 consecutive months, adjusted to maintain serum levels between 200-400 ng/ml and tapered by 50 mg/d per week if patients achieved a complete response). Platelet count, bleeding and other symptoms were evaluated before and after treatment. Adverse events are also recorded throughout the study. In order to report the efficacy and safety of the combination therapy compared to cyclosporin A monotherapy for the treatment of adults with steroid-resistant/relapsed ITP.
The invention discloses a Chinese yew polysaccharide, a preparation method and applications thereof. The preparation method comprises a step of separation and purification. The step of separation and purification comprises the following steps: taking a NaCl solution as the eluent, using a DEAE sepharose flow resin column to separate coarse polysaccharide, carrying out elution to obtain a NaCl solution containing target fraction, wherein the concentration of the target fraction is 0.3 M; taking deionized water as the eluent, using a Sephdex G-10 gel column to separate the target fraction, and obtaining the Chinese yew polysaccharide when the retention time is 30 minutes. The weight average molecular weight of the obtained Chinese yew polysaccharide is 73527 Da, and is composed of glucose, xylose, mannose, arabinose, rhamnose, and galactose according to a mole ratio of 1:0.38:0.31:3.11:1.34:1.92. The skeleton of the Chinese yew polysaccharide is composed of arabinose (1 to 3) and galactose (1 to 4). The Chinese yew polysaccharide has a prominent apoptotic induction effect on stomach cancer cell SGC-7901.
There is conflicting evidence regarding the association between epidural labour analgesia and risk of postpartum depression. Most previous studies were observational trials with limited ability to account for confounders. We aimed to determine if epidural analgesia was associated with a significant change in the incidence of postpartum depression in this randomised controlled trial. We enrolled women aged 21-50 years old with a singleton fetus ≥ 36 weeks gestation. Patients were advised regarding available labour analgesic modalities during enrolment (epidural block; intramuscular pethidine; nitrous oxide; or intravenous remifentanil). On request for analgesia, patients were offered the modality that they had been allocated randomly to first. Blinded investigators recorded patient and obstetric characteristics within 24 h of delivery and assessed for postpartum depression at 6-10 weeks following delivery using the Edinburgh Postnatal Depression Scale (score ≥ 13 considered positive for postpartum depression). The modified intention-to-treat population consisted of all patients who received any form of labour analgesia, while per-protocol consisted of patients who received their randomised modality as their first form of labour analgesia. Of 881 parturients allocated randomly (epidural n = 441, non-epidural n = 440), we analysed 773 (epidural n = 389, non-epidural n = 384); 62 (15.9%) of women allocated to epidural group developed postpartum depression compared with 65 (16.9%) women allocate to the non-epidural group. There were no significant differences in the incidence of postpartum depression between the two groups (adjusted risk difference (95%CI) 1.6 (-3.0-6.3%), p = 0.49). Similar results were obtained with per-protocol analysis (adjusted risk difference (95%CI) -1.0 (-8.3-6.3%), p = 0.79). We found no significant difference in the risk of postpartum depression between patients who received epidural labour analgesia and those who utilised non-epidural analgesic modalities.
It has been reported that regular maintenance of subjects with treated periodontal disease is the key consideration in the long-term periodontal prognosis of these subjects. Periodic prophylaxis may prevent loss of clinical attachment over long periods of time even in patients with less than optimal plaque control. However, there are limitations in routine subgingival re-instrumentation especially in bleeding pockets, as only 50% of these sites improve. Furthermore, the persistence of bleeding pockets increases the risk of disease progression and tooth loss. Thus there is a need for adjuncts that may improve the outcome especially in subjects with recurrent periodontitis during SPT. Some studies reported significantly better results with subgingival administration of local minocycline in residual pockets post initial periodontal therapy over a short period of time. There are few studies assessing the efficacy of topical minocycline gel in subjects with recurrent periodontitis while in SPT, and the long term effect.

The present study will examine the significance of the adjunctive effect of the subgingival application of a 2% minocycline hydrochloride controlled-delivery system (MHS) in comparison to subgingival instrumentation with application of a placebo gel, 3 months after therapy in subjects with recurrent periodontitis undergoing supportive periodontal therapy (SPT) and to assess the substantivity of the gel attributable to the adjunctive delivery of the medication that will be detected at 3 months during a 9-month period of regular SPT.
Atropine Sulfate Injection, USP is a sterile, isotonic solution of Atropine Sulfate in Water for Injection q.s. Sodium Chloride added for isotonicity. pH adjusted with Sulfuric Acid. Preservative free.

Atropine is a white crystalline alkaloid which may be extracted from belladonna root and hyoscyamine or may be produced synthetically. It is used in the form of atropine sulfate because this compound has much greater solubility in water. The structural formula of Atropine is as follows:
The present invention discloses a shedan chuanbei dispersed tablet and a preparation method thereof. The tablet is prepared through innovation of a preparation technology on the basis of the existing preparation. The tablet has the advantages of good therapeutic effect, quick obvious effect, accurate fractional dose, little dosage, convenient carrying, etc. The dispersed tablet can be quickly disintegrated and uniformly dispersed in water. A person can take the tablet in an oral administration mode by drinking water. The dispersed tablet can also be put in a mouth, and the person sucks the dispersed tablet or swallows the dispersed tablet. The dispersed tablet is suitable for adults, children and old people. Simultaneously, the dispersed tablet enhances the quality standard, and people's medicine requirements are further satisfied and ensured, which is of great significance to inherit and carry forward the Chinese medicine heritage, and further satisfy and ensure the people's medicine requirements. The dispersed tablet has the functions for clearing away lung heat, relieving cough and eliminating phlegm. The dispersed tablet is used for cough due to lung heat, excessive phlegm, etc., and the curative effect is obvious. The dispersed tablet is safe effective medicine which is clinically welcome. The dispersed tablet is an ideal product of modern pharmaceutical enterprises.
The present invention relates to a methods, compositions, and admixtures which prevent the aggregation of a population of adipose stromal cells (ASCs), such as an isolated population of adipose stromal cells. In some embodiments, the present invention relates to admixtures and methods of use thereof comprising a population of ASC and a modulator of ASC aggregation. In some embodiments, a modulator of ASC aggregation includes, for example, ionic agents (e.g., heparin), chelating agents (e.g., EDTA), proteolytic agents. (e.g., trypsin or dispase), and agents which inhibit the expression of cell surface receptors and molecules on the surface of ASCs (e.g., inhibitors of integrins expression). In some embodiments, the methods to block ASC aggregration and the admixtures are useful in use of the ASCs to treat various diseases and/or conditions, and increases the safety and/or efficiency of ASCs. The methods, compositions and admixtures have utility in treating a number of conditions including, but not limited to, the treatment of any vascularized organs, such as heart, kidney, liver and the like.
Wisdom teeth extraction can be difficult and patient can suffer post operative swelling and pain. A new piezoelectric technique for wisdom teeth extraction was developed and it showed promising results in terms of surgical effectiveness and patients post operative complications. The aim of the study is to compare the new technique with special designed piezoelectric tools with the traditional one in a randomized controlled way. The same procedures are to be followed for teeth extraction except for the use of a piezoelectric lever in one group and a manual lever in the other one. The study is a mono-center, pragmatic, randomised clinical trial (RCT) of parallel group design. The trial would have one week follow up. All patients referred to the Dental Department of S.Maurizio Hospital (Bolzano, Italy) for the extraction of wisdom teeth are considered eligible for the study.
Patients receive treatment from the long duration therapeutic ultrasound device for 4 hours every day for 6 weeks. The active device emits continuous ultrasound at 3 megahertz (MHz) frequency and 0.132 watts/cm2 intensity.
Methods for treating inflammatory pulmonary diseases by administering to the patient an effective amount of one or more pharmaceutical agents are disclosed. The pharmaceutical agents administered can include antibiotics, steroids, NSAIDs, DMARDs, growth factor receptor inhibitors, PI3K inhibitors, neurotransmitter receptor inhibitors, or protease inhibitors. The dose administered is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease. The pharmaceutical agent is administered to a patient determined to have the disease and at an amount effective to suppress or prevent activity of the disease. The pharmaceutical agent is administered using a transtracheal, transbronchial, or transvascular drug delivery catheter. The pharmaceutical agent can be administered to the patient's pulmonary tissue to suppress reactions in response to bronchial thermoplasty either before, during, or after bronchial thermoplasty.
A cosmetic product contains, in one or more cosmetic components each comprising a cosmetic base, zinc powder and/or copper powder, and an organic acid. The zinc powder and/or copper powder are encapsulated with a hydrophobic encapsulation which prevents the organic acid coming into contact with the zinc powder and/or copper powder. The encapsulating material may be a brittle waxy material such as one comprising stearyl palmitate. The organic acid may be selected from 10-hydroxydecanoic acid, acetyl salicylic acid, alphahydroxy acid, glycolic acid, succinic acid, lactic acid, ferulic acid and hyaluronic acid and mixtures thereof. The composition may be used in a method of applying a cosmetic product for the skin. The composition may also be used in a method of improving the cosmetic appearance of the skin by applying the cosmetic product to the surface of the skin and massaging the skin to break the encapsulation to allow the zinc and/or copper powder to react with the organic acid.
OBJECTIVE: Postoperative delirium is a common and debilitating complication that significantly affects patients and their families. The purpose of this study is to investigate whether there is an effective sedative that can prevent postoperative delirium while also examining the safety of using sedatives during the perioperative period.
METHODS: The net-meta analysis was used to compare the incidence of postoperative delirium among four sedatives: sevoflurane, propofol, dexmedetomidine, and midazolam. Interventions were ranked according to their surface under the cumulative ranking curve (SUCRA).
RESULTS: A total of 41 RCT studies involving 6679 patients were analyzed. Dexmedetomidine can effectively reduce the incidence of postoperative delirium than propofol (OR 0.47 95% CI 0.25-0.90), midazolam (OR 0.42 95% CI 0.17-1.00), normal saline (OR 0.42 95% CI 0.33-0.54) and sevoflurane (OR 0.39 95% CI 0.18-0.82). The saline group showed a significantly lower incidence of bradycardia compared to the group receiving dexmedetomidine (OR 0.55 95% CI 0.37-0.80). In cardiac surgery, midazolam (OR 3.34 95%CI 2.04-5.48) and normal saline (OR 2.27 95%CI 1.17-4.39) had a higher rate of postoperative delirium than dexmedetomidine, while in non-cardiac surgery, normal saline (OR 1.98 95%CI 1.44-2.71) was more susceptible to postoperative delirium than dexmedetomidine.
CONCLUSION: Our analysis suggests that dexmedetomidine is an effective sedative in preventing postoperative delirium whether in cardiac surgery or non-cardiac surgery. The preventive effect of dexmedetomidine on postoperative delirium becomes more apparent with longer surgical and extubation times. However, it should be administered with caution as it was found to be associated with bradycardia.
Ultrasound of the leg with DVT and leg circumference measurement at 3 days, 10 days, and 3 months. Ultrasound data will include data on thrombus resolution, such as size and recanalization present.