anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND PURPOSE: This article aims to identify epigenetic markers and detect early development of hematopoietic malignancies through an epigenome wide association study of DNA methylation data.
MATERIALS AND METHODS: This register-based study includes 1,085 Danish twins with 31 hematopoietic malignancies and methylation levels from 450,154 5'-C-phospate-G-3' (CpG) sites. Associations between methylation levels and incidence of hematopoietic malignancy is studied through time-to-event regression. The matched case-cotwin design, where one twin has a malignancy and the cotwin does not, is applied to enhance control for unmeasured shared confounding and false discoveries. Predictive performance is validated in the independent Older Finnish Twin Cohort.
RESULTS AND INTERPRETATION: We identified 67 epigenetic markers for hematopoietic malignancies of which 12 are linked to genes associated with hematologic malignancies. For some markers, we discovered a 2-3-fold relative risk difference for high versus low methylation. The identification of these 67 sites enabled the formation of a predictor demonstrating a cross-validated time-varying area under the curve (AUC) of 92% 3 years after individual blood sampling and persistent performance above 70% up to 6 years after blood sampling. This predictive performance was to a large extent recovered in the validation sample showing an overall Harrell's C of 73%. In conclusion, from a large population representative twin study on hematopoietic cancers, novel epigenetic markers were identified that may prove useful for early diagnosis.
All subjects will be patch tested with 11 experimental and 11 reference allergens. Rates of positive reactions will be evaluated using Cohen's kappa calculation.
NEW MATERIAL:The polypeptide of formula wherein one or plural amino acids in the amino acid sequence may be deleted from its N-terminal, and having interleukin 2 activity. USE:It has nterleukin 2 activity and is useful as a remedy for immune diseases such as cancer, bacteriosis, viral diseases, immunoinsufficiency, autoimmune diseases, etc. PROCESS:Dulcat 111 cell strain capable of producing interleukin 2 is cultured, and extracted. The 11-12 smRNA fraction containing interleukin 2-mRNA is eluted from RNA obtained by the extraction. cDNA is synthesized from the fraction in vitro to obtain the plasmid vector PBR322 and a recombinant DNA, which is inserted into Escherichia coli X1766. The bacterial strain is cultured to obtain a plasmid DNA fraction, which is digested completely with restriction enzyme PstI to separate the DNA coding the objective peptide.
Method for diagnosing pancreatic tumors by determining expression of the ADAM9 protein (a disintegrin and metalloprotease domain 9). Isolated cells or tissue sections of pancreas are incubated with ADAM9-specific antibodies (Ab) then examined under a microscope for binding of Ab. Independent claims are also included for the following: (1) Ab, for diagnosis of pancreatic tumors, that are bound to a marker, preferably a radioisotope such as technetium-99, that enables representation by tomographic or scintigraphic methods; (2) Ab, bound to a cell-killing agent, for treating pancreatic tumors; (3) use of nucleic acid (I), or its derivatives, specific for the ADAM9 gene, or its RNA, for treating pancreatic tumors; and (4) nucleic acid sequences (II), or their derivatives, having any of the 26 fully defined sequences of 20-23 nucleotides in length (SEQ ID Nos: 1-26) as given in the specification. An example of the sequences (SEQ ID Nos: 1-3) are as follows: GTTCCTGTGG AGCAAAGAGC CCAGCGTCCA CCAACTTATT GCATTTGTGG GAACAGTGTG ACTIVITY : Cytostatic. No details of tests for cytostatic activity are given. MECHANISM OF ACTION : Gene therapy; Immunotoxin; Radioimmunotherapeutic.
The invention discloses a foot drop rehabilitation device based on an electromyographic signal. The whole device comprises an acquisition module, a control module and a stimulation module. Wherein the acquisition module is used for acquiring the motion signal characteristics of the lower limbs of the patient. The control module has two working modes of acquisition and stimulation, only one of the two working modes can work at the same time, and the control module is used for correcting the required electrical stimulation feedback parameters according to the characteristics of the lower limb movement signals of the patient. The electrical stimulation module is used for receiving the signal of the control module to electrically stimulate the patient. The invention also discloses a personalized electro-stimulation technology based on the gait characteristics of the lower limbs of the patient. The device not only realizes the closed-loop feedback control of the electrical stimulation, but also considers the coupling of the electrical stimulation pulse and the gait of the patient, and matches the electrical stimulation type, the action time and the action electrode according to the pre-trained data set, thereby improving the use comfort of the wearer.
Under general anesthesia, the Conventional UAS is inserted to the upper ureter or the ureteropelvic junction. A ureteroscope is inserted through the sheath to the stone site. The sTFT is used to fragment the stone with a power setting of 0.8J and a frequency of 12 - 20Hz. After fragmentation, the stones are removed by a stone basket.
PURPOSE: Inflammation associated endothelial cell (EC) dysfunction is key to atherosclerotic disease. Recent studies have demonstrated a protective role of amitriptyline in cardiomyocytes induced by hypoxia/reoxygenation. However, the mechanism by which amitriptyline regulates the inflammatory reaction in ECs remains unknown. Thus, the aim of this study was to investigate whether amitriptyline protects against inflammation in TNF-α-treated ECs.
METHODS: HUVECs were incubated with amitriptyline (2.5 μM) or TNF-α (20 ng/ml) for 24 h. EdU, tube formation, transwell, DHE fluorescence staining, and monocyte adhesion assays were performed to investigate endothelial function. Thoracic aortas were isolated from mice, and vascular tone was measured with a wire myograph system. The levels of ICAM-1, VCAM-1, MCP-1, phosphorylated MAPK and NF-κB were detected using western blotting.
RESULTS: Amitriptyline increased the phosphorylation of nitric oxide synthase (eNOS) and the release of NO. Amitriptyline significantly inhibited TNF-α-induced increases in ASMase activity and the release of ceramide and downregulated TNF-α-induced expression of proinflammatory proteins, including ICAM-1, VCAM-1, and MCP-1 in ECs, as well as the secretion of sICAM-1 and sVCAM-1. TNF-α treatment obviously increased monocyte adhesion and ROS production and impaired HUVEC proliferation, migration and tube formation, while amitriptyline rescued proliferation, migration, and tube formation and decreased monocyte adhesion and ROS production. Additionally, we demonstrated that amitriptyline suppressed TNF-α-induced MAPK phosphorylation as well as the activity of NF-κB in HUVECs. The results showed that the relaxation response of aortic rings to acetylcholine in the WT-TNF-α group was much lower than that in the WT group, and the sensitivity of aortic rings to acetylcholine in the WT-TNF-α group and WT-AMI-TNF-α group was significantly higher than that in the WT-TNF-α group.
CONCLUSION: These results suggest that amitriptyline reduces endothelial inflammation, consequently improving vascular endothelial function. Thus, the identification of amitriptyline as a potential strategy to improve endothelial function is important for preventing vascular diseases.
PURPOSE: A method for manufacturing a compound of formula 1 or 2, having activities of stimulating the secretion of growth hormone is provided, which is effective and economical comparing with a method for extracting a compound of formula 3, alpha-monolinolein stimulating the secretion of growth hormone, from Astragali radix. The method enables mass production of compounds of formula1 1 and 2 which are very similar to alpha-monolinolein. CONSTITUTION: A compound of alcohol of balance 3 having unsaturated phosphoric acids at the alpha and beta position by ester bond, is reacted with pancreatic lipase for 5-20 minutes under pH 6-8 and 25-40°C to remove unsaturated phosphoric acid at the alpha position only. The reaction is stopped by using mixed solution of isopropyl alcohol/heptane/2M H2SO4 in the ratio of 30-50/3-17/0.3-2 by volume. The compound of formula 2 which has unsaturated phosphoric acid at beta position is unstable, so easily changed into a compound of formula 1 having unsaturated phosphoric acid at alpha position. Unsaturated phosphoric acid is selected from linoleic acid, linolenic acid, palmitoleic acid, arachidonic acid, palmitic acid, or oleic acid. Alcohol of balance 3 is glycerol desirably. The compounds of formula 1 and 2 have activities of stimulating the secretion of growth hormone like alpha-monolinoleic acid(a compound of formula 3) extracted from Astragali radix by organic solvents.
Acute kidney injury (AKI) is a common adverse event in chemotherapy patients. AKI is accompanied by the generation of reactive oxygen species (ROS) and inflammation. Therefore, the management of ROS and inflammation is a potential strategy for AKI mitigation. Herein, polyethylene glycol-coated osmium nanozyme-based antidotes (Os) are developed for imaging-guided photothermal therapy (PTT) in combination with cisplatin (Pt); while, avoiding AKI induced by high-dose Pt. Os nanoantidotes can enhance the efficiency of tumor treatment during combined PTT and chemotherapy and inhibit tumor metastasis by improving the hypoxic and inflammatory tumor microenvironment. Os nanoantidotes preferentially accumulate in the kidney because of their 2-nm size distribution; and then, regulate inflammation by scavenging ROS and generating oxygen to alleviate Pt-induced AKI. Os nanoantidotes can be cleared from the kidneys by urine excretion but can be degraded under hydrogen peroxide stimulation, reducing the bio-retention of these compounds. By integrating PTT with inflammatory regulation, Os nanoantidotes have the potential to reduce the side effects of chemotherapy, offering an alternative route for the clinical management of cancer patients with chemotherapy-induced AKI.
Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular adaption to changes in oxygen levels. How changes in respiration under functional hypoxia (i.e., when intracellular O2 levels limit mitochondrial respiration) are relayed by the electron transfer system to impact mitochondrial adaption and remodeling after hypoxic exposure remains poorly defined. This is largely due to challenges integrating findings under controlled and defined O2 levels in studies connecting functions of isolated mitochondria to humans during physical exercise. Here we present experiments under conditions of hypoxia in isolated mitochondria, myotubes and exercising humans. Performing steady-state respirometry with isolated mitochondria we found that oxygen limitation of respiration reduced electron flow and oxidative phosphorylation, lowered the mitochondrial membrane potential difference, and decreased mitochondrial calcium influx. Similarly, in myotubes under functional hypoxia mitochondrial calcium uptake decreased in response to sarcoplasmic reticulum calcium release for contraction. In both myotubes and human skeletal muscle this blunted mitochondrial adaptive responses and remodeling upon contractions. Our results suggest that by regulating calcium uptake the mitochondrial electron transfer system is a hub for coordinating cellular adaption under functional hypoxia.
PURPOSE:To obtain a new aminoketones useful as a central muscle relaxant by reacting a secondary alcohol in the presence of hypohalides and pyridines and reacting the resultant product with amines in the presence of an aqueous solution of formaldehyde. CONSTITUTION:A compound expressed by formula I [R is formula II to formula VI (R3 is halogen, alkyl, benzyl, furyl, phenyl, etc.; R4 and R5 are phenyl or naphthyl; W is O or S); R1 is H, alkyl, benzyl, methoxy, etc.; R2 is H of alkyl] is reacted in the presence of a compound expressed by the formula M(O-X)n [M is alkali(earth) metal; n is 1 or 2] and compound expressed by the formula VII (Y and Z are H or alkyl) to provide ketones expressed by formula VIII. Then the resultant compound is reacted with amines expressed by the formula NHR6R7 (R6 and R7 are alkyl or mutually bonded to form 5-8 membered ring together with N) in the presence of formamide aqueous solution to provide the compound expressed by formula IX, e.g. 5-(2-piperidinomethylpropionyl)-3- phenylisoxazole.
Congenital cytomegalovirus (cCMV) is among the most common congenital infections globally. Of 85%-90% cCMV-infected infants without symptoms at birth, 10%-15% develop sequelae, most commonly sensorineural hearing loss (SNHL); their childhood neurodevelopmental outcomes are less well understood. Embase and MEDLINE were searched for publications from 16th September 2016 to 9th February 2024 to identify studies reporting primary data on neurodevelopmental outcomes in children with asymptomatic cCMV (AcCMV), measured using assessment tools or as evaluated by the study investigators, clinicians, educators, or parents. The Newcastle-Ottawa scale was applied to studies to assess risk of bias. Of 28 studies from 18 mostly high-income countries, there were 5-109 children with AcCMV per study and 6/28 had a mean or median age at last follow-up of ≥5 years. Children with AcCMV had better neurodevelopmental outcomes than children with symptomatic cCMV in 16/19 studies. Of 9/28 studies comparing AcCMV with CMV-uninfected children, six reported similar outcomes whilst three reported differences limited to measures of full-scale intelligence and receptive vocabulary among children with AcCMV and SNHL, or more generally in motor impairment. Common limitations of studies for our question were a lack of cCMV-uninfected controls, heterogeneous definitions of AcCMV, lack of focus on neurodevelopment, selection bias and inadequate follow-up. There was little evidence of children with AcCMV having worse neurodevelopmental outcomes than CMV-uninfected children, but this conclusion is limited by study characteristics and quality; findings highlight the need for well-designed and standardised approaches to investigate long-term sequelae.
The PMT absent group will feature an 8-minute nutritional information video as an attention control strategy titled, "Vaping Health Effects". During this video intervention, the general risks and benefits of nutrition and lifestyle will be presented. The focus of this video will be on how a balanced diet and proper lifestyle choices (i.e., adequate sleep, diet, etc.) can benefit the participants lives in the short-term and long-term.
This is an up to 50 week, phase 3, clinical trial in patients with estimated glomerular filtration rate (eGFR) ≤ 20 ml/min/1.73m2. It will be comprised of an up to 36-week non-dialysis period (NDP), or until such time as subjects require renal replacement therapy (RRT) with dialysis when they will immediately roll into a 12-week dialysis period (DP). The study will consist of up to 16 clinic visits over a maximum period of 50 weeks. There will be a screening period of up to 14 days after which subjects will be randomized into the NDP in a 2:1 ratio to receive either FC (n=150) or SOC (n=75). Each eligible participant will be randomized to either fixed dose open-label ferric citrate (FC) or standard of care (SOC) treatment. Participants randomized to SOC will receive care directed by their primary nephrologist throughout the study duration with the only restriction being that they cannot receive treatment with FC during the NDP or DP. Participants randomized to FC will receive it throughout the study duration.

220 participants were screened to randomize 200 subjects 2:1 (FC:SOC) into the NDP. It is anticipated that 35-45% of participants will reach the dialysis period (DP) during the 36 week follow up. Participants who initiate RRT with dialysis will enter the Dialysis Period (DP) during which those participants previously assigned to ferric citrate will continue to receive open-label ferric citrate and those previously assigned to SOC will receive open-label, non-FC phosphate binders at the discretion of their treating physician. During this period all participants will be treated to standard of care guidelines which suggest that if serum phosphate is above the upper limit of normal (4.5 mg/dL), it should be reduced. During the DP, dose of P binders, use of ESA, intravenous iron and blood transfusions will be at the discretion of the primary treating nephrologist. Participants assigned to the SOC treatment arm may not receive FC at any point during the study.

Only participants that begin permanent RRT with dialysis will be eligible to enter the 12 week DP. Participants that do not begin RRT after 9 months participation in the NDP will be deemed to have reach the end of study and have end of study procedures performed.
A dental hygiene device has a brush assembly and a control unit. The brush assembly has a handle with suction and irrigation conduits passing therethrough. A brush head has two or more parallel rows of bristles. Suction and irrigation ports are positioned between the rows and coupled to the suction and irrigation conduits. Suction and irrigation tubes are coupled to the suction and irrigation conduits. The control unit has an irrigation outlet coupled to the irrigation tube and an irrigation pump, and a supply reservoir coupled to the irrigation pump. The supply reservoir contains a dental hygiene solution that is pumped from the supply reservoir through the irrigation outlet into the irrigation tube. The irrigation tube transmits the solution to the irrigation conduit and then to the irrigation port, where it is expelled. A suction inlet is coupled to the suction tube, and a suction pump is coupled to the suction inlet. A waste reservoir is coupled to the suction pump, which suctions the solution into the suction port to the suction tube, which transmits the solution to the suction inlet. The suction pump draws the solution from the suction inlet and expels the solution into the waste reservoir. The solution is an aqueous solution of sodium fluoride, from 0.5 to 1.0 milligrams per fluid ounce; and ascorbic acid from 350 to 425 times, bioflavinoids from 3 to 4.5 times, calcium ascorbate from 19 to 20 times, magnesium ascorbate from 9 to 10.5 times, and potassium ascorbate from 19 to 20 times the sodium fluoride concentration.
Orthognathic surgery is currently a common procedure in oral and maxillofacial surgery. The facial region is composed of a complex and dense vascular network, requiring precise, accurate, and delicate surgical techniques on both hard and soft tissues. During intraoral procedures, the surgical field may be limited, making the management of surgical bleeding challenging. Controlled hypotension or hypotensive anesthesia is often employed during major maxillofacial surgeries to optimize conditions. Lowering blood pressure is advantageous as it helps reduce overall blood loss and improves the surgeon's visibility. Therefore, maintaining stable blood pressure within the ideal range during the surgical process is a critical anesthesia objective.

This research emphasizes the prevention of acute kidney injury (AKI) in patients undergoing orthognathic surgery with intentional hypotension during general anesthesia. The goal is to detect the potential renal damage at an early stages, before a significant decline in kidney function occurs, thereby reducing the likelihood of acute kidney injury.
OBJECTIVES: Body mass index (BMI) can affect an individual's health. The night shift is a characteristic of the nursing profession, which is associated with an abnormal BMI. However, few studies have investigated the association between BMI and burnout in Chinese nurses. This study examined the association between BMI and burnout among Chinese nurses.
METHODS: A total of 1863 nurses from 12 tertiary hospitals in Shandong Province of China were selected. BMI was calculated as body weight divided by height squared. The Maslach Burnout Service Inventory General Survey (MBI-GS) was used to measure the level of burnout among nurses. Ordinal logistic regression was used to analyse the association between BMI and burnout.
RESULTS: In this study, the prevalence of normal BMI, underweight, overweight, and obesity was 69.2%, 7.5%, 18.2%, and 5.2%, respectively. The prevalence of high emotional exhaustion, high cynicism, and low personal accomplishment among nurses was 26.1%, 38.7%, and 35.6%, respectively. Nurses who were obese were more likely to have high levels of emotional exhaustion (OR=1.493, 95% CI: 1.011 to 2.206) and cynicism (OR=1.511, 95% CI: 1.014 to 2.253), and nurses who were underweight were more likely to have high levels of cynicism (OR=1.593, 95% CI: 1.137 to 2.232) compared with those who were normal weight.
CONCLUSIONS: Obesity was positively associated with emotional exhaustion and cynicism, and being underweight was only positively associated with cynicism among Chinese nurses. Hospital administrators should consider BMI when taking effective measures to reduce burnout among nurses.
The following variables will be followed: time and location of positive cultures, underlying diseases and severity of illness, recent immunomodulative therapies, physical exam findings, laboratory and radiographical data, antimicrobial usage within 14 days of onset of bacteremia, microbiological data and resistance patterns, choice of antibiotics once organism identified, suspected source of bacteremia, bacteriological outcomes, laboratory results, demographic information, medications, clinical outcome,gender, height, weight, ethnicity, and past medical history (please see attached clinical data collection worksheet dated 4/2005). We will also collect information retrospectively for one year and prospectively for one year. The bacteria in the patient's blood cultures will be subcultured (after the diagnosis has been obtained since the microbiology lab would otherwise destroy the culture) and provided to the honest broker who will deidentify the specimen and link it to the medical information collected (which will also be deidentified by the honest broker). The following evaluation will be performed on these samples. The minimal inhibitory concentration of the antibiotic used in treatment will be performed by the E-Test method (AB Biodisk, Solna, Sweden). Specific mechanisms of antimicrobial resistance will be studied with emphasis on the presence of beta-lactamases produced by the bacteria. This evaluation will be performed by analytical isoelectric focusing techniques as well as PCR and gene sequencing analysis to determine genes encoding beta-lactamases. Biologic samples will be under the control of the principal investigator of this research project. All samples provided to the investigators are deidentified by the honest broker and will be coded with numbers. The information linking these code numbers to the corresponding subjects' identities will be kept in a separate, secure location that only the honest broker has access to. The investigators on this study will keep the samples indefinitely. Samples will be kept in the investigator's laboratory located in Scaife Hall, room 812, 3500 Terrace Street. At no time with the research investigators have access to any patient identifiers.