anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a novel SARS-CoV-2 antiviral pharmaceutical composition and the use thereof to produce a dosage form in the form of tablets or capsules. The composition is intended for treating RNA viral diseases and, inter alia, for the prevention and treatment of SARS-CoV-2-mediated COVID-19. The present SARS-CoV-2 antiviral pharmaceutical composition contains 40-48 wt% micronized favipiravir, comprising a D90 fraction of micronized particles having a size within the range of ≤40.6 - ≤211 μm, the remainder being excipients. The composition preferably contains 44.0-47.6 wt% micronized favipiravir, comprising the aforesaid D90 fraction. The excipients are selected from among fillers, disintegrants, binders, glidants and lubricants. The dosage form in the form of tablets or capsules of the composition is called Avifavir. Using the given D90 fraction of micronized FVP renders the process of manufacturing the claimed SARS-CoV-2 antiviral pharmaceutical composition significantly easier and less expensive since it does not necessitate separation of the micronized particles. In addition, the composition Avifavir is more effective since it significantly reduces COVID-19 treatment time in comparison to known drugs.
Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on sensory Schwann cells. In polymodal nociceptors, sensory Schwann cells signal mechanical, but not cold or heat pain. Terminal Schwann cells also surround mechanoreceptor nerve-endings within the Meissner's corpuscle and in hair follicle lanceolate endings that both signal vibrotactile touch. Within Meissner´s corpuscles, two molecularly and functionally distinct sensory Schwann cells positive for Sox10 and Sox2 differentially modulate rapidly adapting mechanoreceptor function. Using optogenetics we show that Meissner's corpuscle Schwann cells are necessary for the perception of low threshold vibrotactile stimuli. These results show that sensory Schwann cells within diverse glio-neural mechanosensory end-organs are sensors for mechanical pain as well as necessary for touch perception.
As the rate of vaccination increases, preventable diseases and their negative effects decrease; Nevertheless, the significance of vaccine-related side effects is increasing. The most prevalent complications in vaccine applications are local reactions such as pain, swelling, and erythema at the injection site. The most frequent pain in these reactions develops after diphtheria-tetanus vaccine in which aluminum is used as an adjuvant. Diphtheria-tetanus vaccine is generally administered to the deltoid region by intramuscular injection (IM), and most pregnant women complain about the pain that they experience during and after administration of diphtheria-tetanus vaccine. Nurses have a great responsibility in reducing and eliminating the pain felt by patients during operations. The success of pain management is related to nurses' knowledge and skills. If the pain that an individual will feel due to the piercing of the skin with a needle during intramuscular injection application is decreased or reduced to minimum, the anxiety and fear that the person will experience may abate. Therefore, to reduce pain and anxiety in individuals during injection; nurses use many non-pharmacological methods. ShotBlocker (Bionix, Toledo, OH) is one of the methods that can be used to reduce pain caused by IM injections. This small, flat, U-shaped plastic device used by holding it on the skin surface during injection did not have any side effects. ShotBlocker has a surface of 2 mm thick with rounded nubs to stimulate the skin. The surface of the plastic device is placed on the skin just before the injection; there is a hole in the center where the injection is administered. The rounded nubs on the surface of the plastic device do not damage the skin, these rounded nubs that create a slight pressure provide a warning for the Gate Control Theory. ShotBlocker's mechanism of action is thought to reduce pain by stimulating nerve endings faster with pressure of rounded nubs on the device. This stimulation decreases pain by blocking pain signals temporarily during injections and by inhibiting the central nervous system.
Intervention on self-regulation will be carried out through a non-immersive virtual reality platform, "SR-Mrehab: Un colegio emocionante" in which students must conduct a series of activities designed specifically for this purpose. These activities will be performed by the children using mainly their hands to manage the virtual objects showed in the screen. To do this, our system make use of a Kinect motion sensor connected to the computer to control the body movements of the children. Moreover, our system records some relevant data of the execution of these activities for further analysis of the children's performance.The exercises will be divided into two blocks, emotional regulation (ER) and cognitive regulation (CR), in a total of 10 sessions, once a week, performing an exercise of each block per session. Each session will consists of 60 minutes. .
Urticaria is characterized by transient itchy symptoms on the skin, usually accompanied by swelling, which is caused by mast cell activation leading to increased vascular permeability and dilation of the dermis. Urticaria involves recurrent activation of mast cells, T cells, eosinophils, and other immune cells around lesioned venules, with complex regulatory systems affecting mast cell functions, potentially contributing to urticaria pathogenesis. The direct causal relationship between immune cells and urticaria is currently unclear. To address this, our study utilized a bidirectional Mendelian randomization analysis, employing instrumental variables (IVs) associated with immune cells and urticaria, to investigate this causal relationship. First, by utilizing Genome-wide Association Study (GWAS) data, we identified 31 immunophenotypes associated with urticaria risk, with 18 increasing and 13 decreasing the risk. Through rigorous criteria, we identified 4 immunophenotypes that have a strong causal relationship with urticaria. Notably, HLA DR+ CD4+AC, CD45 on CD8br, and HLA DR on plasmacytoid dendritic cells were associated with an increased risk, while CD8dim NKT %lymphocyte was identified as a protective factor. Sensitivity analyses, including the MR-Egger intercept test, scatter plots, funnel plots, and leave-one-out analysis, supported the robustness of the findings. Reverse MR analysis suggested an inverse causal effect of urticaria on CD8dim NKT %lymphocyte, reinforcing the potential bidirectional nature of the relationship between urticaria and immune cell phenotypes. Our research substantiates the bidirectional causal relationship between immune cells and urticaria, thus benefiting for urticaria-targeted therapy development.
Chronic low back pain (CLBP) is a common disorder worldwide, affecting young and old adults alike. Kinematic studies of lumbar-pelvic mobility allied with surface electromyogram (sEMG) can assist in the assessment and management of CLBP. This systematic review aimed to synthesise the evidence relating to the diagnostic accuracy and reliability of the surface electromyogram in chronic low back pain patients during flexion-extension-relaxation tasks. Five databases (PubMed, Scopus, Web of Science, Embase and CINAHL) were searched for eligible studies from inception to March 2024. The risk of bias assessment for the included studies was conducted using the QUADAS-2 tool. Studies included adults (≥18 years) with CLBP > 3 months, reported diagnostic accuracy or reliability measures for sEMG during flexion-extension-relaxation tasks. Eleven studies were included in our systematic review. The risk of bias was found to be high for patient selection, reference standard and flow and timing domains with low risk of bias for the index test domain in most of the included studies. For diagnostic accuracy, six studies reported values ranging between 56-99 % indicating poor to excellent accuracy levels. Four studies reported values between 76-100 % for sensitivity and 65-100 % for specificity indicating sufficient to excellent accuracy levels. Seven studies reported moderate to excellent reliability levels, ranging between 0.66-0.99. This systematic review found the diagnostic accuracy and reliability of sEMG in CLBP patients to range from poor to excellent levels. This systematic review adds knowledge for practitioners and clinicians regarding the use of sEMG during forward, flexion and relaxation tasks/movements.
Participants will be randomized to 1000 mg of docosahexaenoic acid (DHA) administered PO daily (5- 200mg capsules of DHA). Participants will be supplemented daily PO between 18-20 weeks gestation through 6 weeks post-partum.
The invention relates to an anti-aging skin care product and particularly discloses a salicornia herbacea cell hair-growing essence and a preparation method thereof. The salicornia herbacea cell hair-growing essence includes the following components: 1) a group A: 2% of cetyl alcohol, 2% of stearic acid, 1% of glycerin monostearate, 2% of Vaseline, 10% of wool fat, 0.2% of vitamin E and 0.5% of propolis; 2) a group B: 10% of a stem cell extract, 1% of soybean phopholipid, 2% of protein hydrolysate, 5% of glycerin, 0.5% of lactic acid, 1% of a preservative. All the components are added with deionized water to 100%. The preparation method includes the steps of (1) mixing the components in the group A, heating the components to 70-75 DEG C; (2) heating the deionized water to 70-75 DEG C; (3) adding the group A to the deionized water, mixing the components uniformly, and stirring the mixture and decreasing the temperature; and (4) when the temperature is reduced to lower than 40 DEG C, adding the components in the group B and mixing the components uniformly. When the cell hair-growing essence is absorbed through scalp, the cell hair-growing essence can be permeated into hair follicles, thereby comprehensively improving alopecia. In addition, the cell hair-growing essence enables hair keratin to be differentiated, thereby quickly changing and replacing the senile protein and further improving elasticity of hair. The cell hair-growing essence promotes synthetic activation of protein and improves softness of hair.
PURPOSE: Post-operative urinary retention (POUR) is a known complication of hernia surgery. Minimally invasive inguinal hernia repair (IHR) is typically done under general anesthesia with neuromuscular blockade (NMB), which is commonly reversed with an anticholinesterase inhibitor paired with an anticholinergic agent. Sugammadex is a unique NMB reversal agent that does not have to be paired with an anticholinergic. We sought to explore the role of sugammadex in reducing the rate of POUR following these procedures.
METHODS: Data were collected retrospectively at a single institution between February 2016 and October 2019. We identified and studied patients who underwent minimally invasive IHR and received either sugammadex or neostigmine/glycopyrrolate for NMB reversal. The primary endpoint was POUR requiring bladder catheterization. Secondary endpoints included post-operative and 30-day readmissions.
RESULTS: 274 patients were included in this study (143 received neostigmine and glycopyrrolate, 131 sugammadex). The sugammadex patients were on average 5 years older than the neostigmine/ glycopyrrolate patients (63.2 vs 58.2, p = 0.003), and received less median intravenous fluids (IVF) (900 ml vs 1000 ml; p = 0.015). There was a significant difference in the rate of POUR between the sugammadex and neostigmine/glycopyrrolate patients (0.0% vs 8.4%, p ≤ 0.001). The difference remained significant after controlling for age and IVF. The odds of POUR for those who received neostigmine/glycopyrrolate were 25 × higher than the odds of those who received sugammadex.
CONCLUSION: The results of this study reflect the protective role of sugammadex against POUR in minimally invasive IHR cases.
Disclosed in the present invention are a multi-modal microbubble contrast agent, a preparation method therefor and an application thereof. The multi-modal microbubble contrast agent is prepared from the following raw materials: phospholipid and indocyanine green (ICG). The mass ratio of phospholipid to ICG is (20-1000):1. The multi-modal microbubble contrast agent provided by the present invention is composed of a nanostructure formed by self-assembling liposomes in the form of microbubbles as vectors, with ICG, and can integrate a plurality of imaging modes of fluorescence, photoacoustic, and ultrasound. Moreover, before the microbubbles are oscillated, a fluorescent signal of a solution is weaker, a photoacoustic signal is stronger, and no ultrasonic sound is present. After the microbubbles are oscillated, the photoacoustic signal of the solution is weakened, the fluorescent signal is enhanced, and the ultrasonic signal is enhanced. The targeted blasting of the microbubbles is realized under the ultrasonic action, the fluorescent signal of the solution is weakened, and the photoacoustic signal is enhanced. The fluorescence and photoacoustic ratio imaging can accurately locate tumor and metastatic lymph node, thereby providing more diagnostic information for the clinic.
OBJECTIVES: I. Determine the efficacy of temozolomide in terms of complete and partial response rates in patients with metastatic non-small cell lung cancer. II. Determine the safety of this regimen in these patients. III. Determine the time to progression and overall survival in patients treated with this regimen. IV. Determine the quality of life and changes in disease-related symptoms in patients treated with this regimen.

OUTLINE: This is a multicenter study. Patients receive oral temozolomide daily on days 1-7 and 15-21. Treatment continues every 4 weeks for a maximum of 6 months in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, every 4 weeks during study, and then every 8 weeks after study. Patients are followed for 1 month and then every 8 weeks thereafter.

PROJECTED ACCRUAL: A total of 15-60 patients will be accrued for this study.
The Dance Group will participate in 1-hour group improvisational dance lessons 2x/week for 12 weeks. Improvisational dance classes are grounded in 4 principles that shape the tone of the class and result in a sense of social belonging: non-judgment, non-competitiveness, curiosity, and playfulness. The following training strategies are used to maintain: active imagination, variability, and pacing.
There are several biological, genetic, and environmental variables that contribute to lung cancer, which is one of the main causes of cancer-related death globally. In addition to exposure to radon gas, air pollution, and occupational dangers like asbestos, smoking is a major risk factor because it releases carcinogens like nitrosamines and polycyclic aromatic hydrocarbons (PAHs) into the lungs. The risk of developing lung cancer is also influenced by genetic predispositions, such as variations in genes like EGFR, KRAS, and TP53. Additionally, new research emphasises how epigenetic changes, such as DNA methylation and histone acetylation, affect the expression of genes connected to the development of cancer. In determining risk and spotting early indicators of lung cancer, biomarkers have become important instruments. Cell-free DNA (cfDNA), circulating tumour cells (CTCs), and certain microRNAs (miRNAs) in blood are non-invasive biomarkers that indicate tumour heterogeneity and load. Molecular indicators include anaplastic lymphoma kinase (ALK) rearrangements, epidermal growth factor receptor (EGFR) mutations, and programmed death-ligand 1 (PD-L1) expression have proved very important in tailoring the therapy of lung cancer. Inflammatory indicators such as interleukins and C-reactive protein (CRP) are also linked to the prognosis of lung cancer. Finding and confirming these biomarkers is essential for improving early detection, tracking the course of the disease, and directing focused treatments. As research progresses, combining molecular, genetic, and environmental insights might improve lung cancer care, prevention, and early diagnosis, thereby lowering the disease's worldwide burden.
<P>PROBLEM TO BE SOLVED: To provide novel angiogenesis inhibitors effective, safe and highly practical for inhibition of angiogenesis in various diseases, and to provide a method for screening the same.  <P>SOLUTION: The active ingredients of the angiogenesis inhibitors of the present invention comprise ansamycin antibiotics such as rifampicin, rifamycin SV and 3-formyl rifamycin, which have long been used extensively as antibacterial agents for treating tuberculosis or Gram-positive bacterial infections. The active ingredients of the present invention have excellent angiogenesis-inhibiting activity. The angiogenesis inhibitor of the present invention is effective for inhibition of angiogenesis in malignant tumors, diabetic retinopathy, retinal angiogenesis, inflammatory diseases, and angiogenesis accompanying cardiovascular remodeling, etc., and can be used as therapeutic agents against each disease, etc. Further, the screening method of the present invention makes it possible to perform an effective screening of angiogenesis-inhibiting substances by detecting angiogenesis-inhibiting signals based on gene expression levels.  <P>COPYRIGHT: (C)2008,JPO&INPIT
During the recent yellow fever (YF) epidemics in Brazil, human cases were attributed to spillover infections via sylvatic mosquito transmission. Despite YF virus (YFV) transmission in major urban centers with insufficient vaccination coverage and abundant populations of the domestic vector, Aedes aegypti, there was no evidence of human-amplified transmission. Furthermore, the historic absence of YF in Asia, despite abundant Ae. aegypti and an immunologically naive human population, is unexplained. We tested the hypothesis that pre-existing, heterologous flavivirus immunity, specifically from dengue (DENV) and Zika (ZIKV) viruses, limits YFV viremia and transmission by Ae. aegypti. We infected cynomolgus macaques with DENV or ZIKV, then challenged them 6-9 months later with YFV. We then measured viremia and disease and allowed Ae. aegypti mosquitoes to feed during peak macaque viremia. Although prior heterologous immunity had variable effects on disease, DENV and ZIKV immunity consistently suppressed YFV viremia. Despite no statistical difference due to a small sample size, the suppression in viremia led to a significant reduction in Ae. aegypti infection and a lack of transmission potential. These results support the hypothesis that, in DENV- and ZIKV-endemic regions such as South America and Asia, human flavivirus immunity suppresses YFV human amplification potential, reducing the risk of urban outbreaks.
Thyroid surgery often results in ischemia-reperfusion injury (IRI) to the parathyroid glands, yet the mechanisms underlying this and how to ameliorate IRI remain incompletely explored. Our study identifies a polyphenolic herbal extract-gallic acid (GA)-with antioxidative properties against IRI. Through flow cytometry and CCK8 assays, we investigate the protective effects of GA pretreatment on a parathyroid IRI model and decode its potential mechanisms via RNA-seq and bioinformatics analysis. Results reveal increased apoptosis, pronounced G1 phase arrest, and significantly reduced cell proliferation in the hypoxia/reoxygenation group compared to the hypoxia group, which GA pretreatment mitigates. RNA-seq and bioinformatics analysis indicate GA's modulation of various signaling pathways, including IL-17, AMPK, MAPK, transient receptor potential channels, cAMP, and Rap1. In summary, GA pretreatment demonstrates potential in protecting parathyroid cells from IRI by influencing various genes and signaling pathways. These findings offer a promising therapeutic strategy for hypoparathyroidism treatment.
The invention relates to nucleophile-reactive sulfonated compounds used as precursors to (radio)labelled (bio)mo - lecules suitable mainly for medical applications. The aim of the invention is to provide novel prosthetic compounds or groups, the synthesis of which is straightforward, easy and automatable, enabling access to economical and effective, (radio)labelled, complex and fragile - especially water-soluble and more especially amine-containg- (bio)molecules. The aim is achieved by the invention, which involves precursors and compounds of respective formulae (1p), (1). Said nucleophile-reactive sulfonated compounds are pro - (laced by pre-introduction of a nucleophilic compound R*, e.g. Fluorine- 18, through an unusal nucleophile-induceci ring-opening reaction of the sultone (e.g. 1,3-propanesultone) moiety of the precursor. The invention also relates to the rnethods for producing the abovementioned precursors and compounds, as well as for the conjugation of these compounds with (bio)molecules, and to the drugs obtained through this method.
A method and system for interactive patient-specific simulation of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. A computational domain is generated from the patient-specific anatomical model of the liver. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the circulatory system of the liver by solving a bio-heat equation for each node on the level-set representation using a Lattice-Boltzmann method (LBM) implementation. Cellular necrosis in the liver is computed based on the simulated heat diffusion. Visualizations of a computed necrosis region and temperature maps of the liver are generated. A user input is interactively received to modify the position of the virtual ablation probe, the heat diffusion and cellular necrosis is re-simulated based on the user input, and the visualizations of the computed necrosis region and the temperature maps are updated.
OBJECTIVES: Sphenomaxillary plate (SMP) is an inconstant bony septum separating the maxillary and sphenoid sinuses. Neglecting the SMP during endoscopic sinus surgery may lead to mistaking the sphenoid sinus for the posterior ethmoid cell with potentially dangerous consequences. However, its proper identification may allow planned sphenoidotomy through the posterior wall of the maxillary sinus or to enlarge transnasal or transethmoidal sphenoidotomy. The aim of this study was to evaluate (1) the incidence and morphology of the SMP and (2) possibility and safety of trans-SMP sphenoidotomy.
METHODS: In the radioanatomical part of the study multiplanar reconstruction analysis of 117 consecutive paranasal sinus CT scans was conducted. In the clinical part of the research, trans-SMP sphenoidotomy was performed in consecutive patients operated on for chronic rhinosinusitis.
RESULTS: The SMP was found in 25% of sides (34% of patients). It was constantly located superolateral to the posterior insertion of the middle turbinate. The SMP formed the prominence on the posterior wall of the maxillary sinus that could be identified using volume rendering in 11% of sides (19% of patients). 30 trans-SMP sphenoidotomies were performed in 18 patients. The SMP prominence was identified in 15 sides. In absence of SMP prominence, identification of the SMP was still possible using other anatomical landmarks.
CONCLUSIONS: The SMP is present in over 30% Caucasian subjects at least on one side. Sphenoidotomy through the SMP is feasible and safe.