anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Intravenous

Aminocaproic Acid Injection, USP is administered by infusion, utilizing the usual compatible intravenous vehicles (e.g., Sterile Water for Injection, Sodium Chloride for Injection, 5% Dextrose or Ringer’s Injection). Although Sterile Water for Injection is compatible for intravenous injection the resultant solution is hypo-osmolar. RAPID INJECTION OF AMINOCAPROIC ACID INJECTION UNDILUTED INTO A VEIN IS NOT RECOMMENDED.

For the treatment of acute bleeding syndromes due to elevated fibrinolytic activity, it is suggested that 16 to 20 mL (4 to 5 g) of aminocaproic acid in 250 mL of diluent be administered by infusion during the first hour of treatment, followed by a continuing infusion at the rate of 4 mL (1 g) per hour in 50 mL of diluent. This method of treatment would ordinarily be continued for about 8 hours or until the bleeding situation has been controlled.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer unless the solution is clear and seal is intact. Discard unused portion.
Patients receive irinotecan hydrochloride IV over 90 minutes and cetuximab IV over 1-2 hours on days 1 and 15, and utomilumab IV over 1 hour on day 2. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
A system for monitoring activity of an executable application includes an input processor, an event processor, a monitoring processor, and an output processor. The input processor receives a message identifying an event representing activity performed by an executable application and containing data associated with the event. The event associated data includes a start and stop time of the event. The event processor stores a record of the identified event and the event associated data in a record repository. The monitoring processor selects particular events to use in monitoring a particular activity of the executable application in response to a received command. The output processor collates event-associated data, retrieved from the record repository, for the selected particular events, and processes and formats the collated event data for presentation to a user.
Introduction: Physical activity in adolescence plays an important role in reducing the lifetime risk of chronic disease. Recent studies have shown that individuals with amblyopia may have difficulties with coordinating balance and may be at greater risk of developing fine motor impairments. The purpose of this study was to determine if there is an association between the presence of amblyopia and physical activity (PA) in adolescents. Methods: Adolescent patients aged 12-18 years with a history of childhood amblyopia were age- and gender-matched to control patients with no other ocular pathology aside from refractive error. Each participant's best corrected visual acuity and refractive error were recorded in addition to their height and weight to calculate body mass index (BMI). A 32-question electronic survey was used to calculate self-reported physical activity level (PAL) score and type of PA over the previous seven days. The Ainsworth Compendium of Physical Activities was taken as a reference to calculate Metabolic Equivalent of Task (MET) minutes for the most frequently performed activity. Results: A total of 26 adolescents with amblyopia (10 strabismic, 16 anisometropic) and 26 healthy controls were recruited. The MET-minute values were 2404.3 ± 2313.9 in the control group and 905.6 ± 1196.0 in the amblyopia group (p = .008). The PAL scores were similar between amblyopia and control groups (1.15 ± 0.70 versus 1.24 ± 0.60, p = .63); however, BMI was significantly higher in amblyopia participants (25.2 ± 6.3 versus 21.1 ± 5.4, p = .003). When compared with controls, amblyopes perceived physical activity to be of significantly lower importance in their lives compared to controls (p = .009). Discussion: Amblyopic adolescents may represent a population with increased vulnerability to significantly lower energy expenditure and higher BMI. Future studies with a larger number of participants and further investigation into the impact of refractive error on physical activity are warranted.
Anemia is common in critically ill patients undergoing continuous renal replacement therapy (CRRT). We investigated the impact of anemia requiring red blood cell (RBC) transfusion or erythropoiesis-stimulating agents (ESAs) on patient outcomes after hospital discharge in critically ill patients with acute kidney injury (AKI) requiring CRRT. In this retrospective cohort study using the Health Insurance Review and Assessment database of South Korea, 10,923 adult patients who received CRRT for 3 days or more between 2010 and 2019 and discharged alive were included. Anemia was defined as the need for RBC transfusion or ESAs. Outcomes included cardiovascular events (CVEs) and all-cause mortality after discharge. The anemia group showed a tendency to be older with more females and had more comorbidities compared to the control group. Anemia was not associated with an increased risk of CVEs (adjusted hazard ratio [aHR]: 1.05; 95% confidence interval [CI]: 0.85-1.29), but was associated with an increased risk of all-cause mortality (aHR: 1.41; 95% CI 1.30-1.53). For critically ill patients with AKI requiring CRRT, anemia, defined as requirement for RBC transfusion or ESAs, may increase the long-term risk of all-cause mortality.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. 

Breast Cancer

The safety data below were collected from 1,492 women who received doxorubicin hydrochloride at a dose of 60 mg/m2 and cyclophosphamide at a dose of 600 mg/m2 (AC) every 3 weeks for 4 cycles for the adjuvant treatment of axillary lymph node positive breast cancer. The median number of cycles received was 4. Selected adverse reactions reported in this study are provided in Table 2. No treatment-related deaths were reported in patients on either arm of the study.

Table 2. Selected Adverse Reactions in Patients with Early Breast Cancer Involving Axillary Lymph Nodes
The invention relates to cream shampoo containing inorganic salt and Chinese herbs and with good scurf-removing and antipruritic effects, and a method for preparing the cream shampoo, which belongs to the field of hair care products. The invention is characterized in that the cream shampoo contains additives with scurf-removing and antipruritic effects, which are univalent and bivalent inorganic salt and herbal extract, wherein univalent inorganic salt includes sodium chloride, potassium chloride and lithium chloride; bivalent inorganic salt includes magnesium chloride, magnesium sulfate, zinc chloride, zinc sulfate, copper chloride, copper sulfate, cobalt chloride, cobalt sulfate, manganese chloride and manganese sulfate. The inorganic salt has antibacterial and bactericidal effects. The Chinese herbs include Chinese angelica root, lightyellow sophora root, goldthread root, baical skullcap root, ginger, fleeceflower root, shrub chastetree fruit, mulberry bark, chuanxiong rhizome and Chinese arborvitae leaf. The herbal extract is in the form of water extract or dried powder and has antibacterial and hair conditioning effect. The inorganic salt, the herbal extract and shampoo matrix are compounded with good synergistic effect. The shampoo has remarkable scurf-removing and antipruritic effects and contains pure natural additives without dependence or side effects. The compound shampoo also has good foaming and dry/wet combing properties, good luster and smoothness and good antistatic capability.
The occurrence of immune-related cholecystitis and the subsequent immunotherapy re-challenge has been rarely reported. A patient diagnosed with recurrent nasopharyngeal carcinoma, developed immune-related cholecystitis after the sixth and eighth cycles of camrelizumab respectively. The patient's symptoms and laboratory test results showed improvement after conservative treatment. Then we chose zimberelimab, a fully humanized PD-1 antibody, as a replacement for camrelizumab in maintenance therapy and successfully completed 37 cycles of zimberelimab (240 mg every 2 weeks per cycle). Surprisingly, the patient experienced no immune-related adverse event and remained in complete remission with a progression-free survival of 28.8 months. The use of Zimberelimab as rechallenge immunotherapy may be an optional choice after managing immune-related cholecystitis induced by other PD-1 antibodies.
PURPOSE:To produce an implant material having a great affinity for a living body and high strength by adding P and Ca compds. to a soln. prepd. by hydrolyzing alkyl silicate to obtain sol, introducing hydroxyl groups into a metal chloride layer formed on the surface of a metal, dipping this metal in the sol, drying and calcining a formed sol film. CONSTITUTION:Ethyl silicate is hydrolyzed by mixing with a soln. of ethanol in hydrochloric acid and the resulting soln. is mixed with calcium ethoxide and phosphoric acid to obtain sol. A metal bar such as a stainless steel bar is heated in gaseous HCl or Cl2 to form a metal chloride layer on the surface of the bar and this bar is put in water, heated, taken out and dried to introduce hydroxyl groups into the metal chloride layer. The bar is then dipped in the sol and a formed sol film is dried at about 60 deg.C and heated at about 350 deg.C. An implant material having a great affinity for a living body and high strength and useful as an artificial tooth or bone is produced.
Hypoxia is a hallmark of cancer development. However, the molecular mechanisms by which hypoxia promotes tumor metastasis are not fully understood. In this study, we demonstrate that hypoxia promotes breast cancer metastasis through suppression of ΔNp63α in a HIF1α-independent manner. We show that hypoxia-activated XBP1s forms a stable repressor protein complex with HDAC2 and EZH2 to suppress ΔNp63α transcription. Notably, H3K27ac is predominantly occupied on the ΔNp63 promoter under normoxia, while H3K27me3 on the promoter under hypoxia. We show that XBP1s binds to the ΔNp63 promoter to recruit HDAC2 and EZH2 in facilitating the switch of H3K27ac to H3K27me3. Pharmacological inhibition or the knockdown of either HDAC2 or EZH2 leads to increased H3K27ac, accompanied by the reduced H3K27me3 and restoration of ΔNp63α expression suppressed by hypoxia, resulting in inhibition of cell migration. Furthermore, the pharmacological inhibition of IRE1α, but not HIF1α, upregulates ΔNp63α expression in vitro and inhibits tumor metastasis in vivo. Clinical analyses reveal that reduced p63 expression is correlated with the elevated expression of XBP1, HDAC2, or EZH2, and is associated with poor overall survival in human breast cancer patients. Together, these results indicate that hypoxia-activated XBP1s modulates the epigenetic program in suppression of ΔNp63α to promote breast cancer metastasis independent of HIF1α and provides a molecular basis for targeting the XBP1s/HDAC2/EZH2-ΔNp63α axis as a putative strategy in the treatment of breast cancer metastasis.
BACKGROUND: Scalp cooling is an increasingly recognized non-pharmacologic approach to minimize chemotherapy-induced alopecia (CIA). Several commercially available machine-based and manual scalp cooling systems are available; however, literature reports of effectiveness are highly variable. The purpose of this study was to determine real-world tolerability and subjective effectiveness of a manual cold capping system in minimizing CIA across a variety of patient race and hair types. This study was a single-institution review of outcomes from manual cold capping.
METHODS: We identified retrospective cohort of adult patients who presented to discuss cold capping between January 14, 2019, and March 31, 2022. Data collected from medical records included demographics, decision to pursue/continue cold capping, diagnoses, chemotherapy regimens, hair characteristics (length, thickness, coarseness, type), and subjective perception of percentage of hair retained. Those with successful vs. unsuccessful cold capping (≥ 50% vs. < 50% of hair retained) were compared based on the patient-level factors of interest.
FINDINGS: A total of 100 patients initiated cold capping during the study period, and 95% of them completed cold capping. The majority of patients who started cold capping completed it. The median-reported percentage of hair maintained was 75%, and 82/89 (92.1% of patients) had favorable results, defined as ≥ 50% of hair retained. The only patient-level factor associated with favorable response was chemotherapy regimen, with fewer patients receiving doxorubicin-containing regimens having successful hair retention compared to other chemotherapy types (71.4% successful results vs. 95.7% for those receiving paclitaxel-containing regimens and 96.6% for those receiving docetaxel-containing regimens (p = 0.018). There was no difference in success based on patient race/ethnicity or hair characteristics.
INTERPRETATION: The overall effectiveness (92.1%) in this study is consistent to higher than many literature reports. One possible reason for the high success in our cohort is compliance with cold capping protocols, meaning applying the cap in the appropriate manner and wearing the cap for the prescribed durations, which may impact effectiveness.
Phytoconcentrated composition comprises Cannabis sativawith antiinflammatory, antispasmodic and analgesic effects, and an excipient comprising at least castor oil in the form of pharmaceutical preparation and vegetable oils mixed with essential oil, preferably grape seed oil or almond oil, where the antiinflammatory agents comprise e.g. an extract of Harpagophytum Procumbensin the form of a dye obtained from the mother antiinflammatory agents comprising Copaifera martii Hayne, Coriandrum sativumand Cuminum cyminum. Phytoconcentrated composition comprises Cannabis sativawith antiinflammatory, antispasmodic and analgesic effects, where: the antiinflammatory agents comprise an extract of Harpagophytum Procumbensin the form of a dye obtained from the mother antiinflammatory agents comprising Copaifera martii Hayne, Coriandrum sativum, Cuminum cyminum, Black Spruce- Picea mariana, Artemisia dracunculus L., Eucalyptus citriodora, Eucalyptus, Ferula galbanifluageranium rosat or fragrant- Pelargonium asperum, Helichrysum gymnocephalum, Innula graveolens, Cedrelopsis graveii, Lavender- Lavandula angustifolia Mill ssp.Lavandula angustifolia, Maillette- Lavandula angustifolia, Lavandula latifoliaMedicus cineolifera, Lavandula stoechas L., Lavandula latifolia, Lavandula burnatiisuper Ledum groenlandicum, Cymbopogon flexuosus, Litsea cubeba, Litsea citrata, Lippia citriodora, Zanthoxylum armatum, Tanacetum annuumCitrus hystrix DC, Citrus aurantium L. ssp.amara var. pumilia, Litsea cubebaPersoon, Litseacitrate Pogostemon cablin, Nardostachys jatamansi, Mentha piperita, Mentha citrata L., Melissa officinalis, and Nepeta cataria L.; the antispasmodic agents comprise Cuminum cyminum, Jasminvim officinale, Ocimum basilicum, Illicium verum, Citrus aurantium ssp., Matricaria recutita, Chamaemelum nobile, Elettaria cardamomum, Citrus aurantifolia, Cymbopogon winterianus, Picea mariana, Artemisia dracunculus L., Foeniculum vulgare ssp., Ferula galbaniflua- Gaultheria procumbensor fragrant, Geranium Pelargoniumasperum rosat or fragrant, Lavandula angustifolia, Angustifolia maillette- Cananga odarata thymus vulgaris L.; and the analgesic agents comprise maceration of flowers of Calendula officinalis, Chamaemelum nobile, Foeniculum vulgare ssp., Eugenia caryophyllus, Syzygium aromaticum, Eugenia caryophyllus, Helichrysum gymnocephalum Cedrelopsis graveii, Laurus nobilis(preferred), Lavandula angustifolia, Mentha arvensis L.and Mentha piperita. An independent claim is included for: (1) preparing the phytoconcentrated composition comprising cold mixing the essential oils based of Rosmarinus officinaliscamphor, Laurus nobilis, Canabis sativa, a tincture of Harpagophytummixed with the vegetable oil in the form of the pharmaceutical preparation and grape seed oil or sweet almond oil; and (2) a process for conservation of the phytoconcentrated composition, by maintaining the composition at a temperature of 5-7[deg] C and at a specified atmospheric pressure without chemical additives. ACTIVITY : Anticonvulsant; Muscular-Gen. MECHANISM OF ACTION : None given.
OBJECTIVE: Aim: To study the state of extracranial carotid vessels in patients with atherothrombotic stroke in the early recovery period (ASERP) according to duplex scanning data.
PATIENTS AND METHODS: Materials and Methods: 130 patients in ASERP, were studied. 69 men and 61 women. aged (60.42}7.4) years. Duplex scanning of the vessels of the neck was performed on a Siemens Acuson X 300 device with a linear multi-frequency sensor of 4-10 MHz. The classification of stenozoocclusive lesions of vessels was carried out according to the classification of B.V. Gaidar. Atherosclerotic plaques (AP) are divided into 5 types according to the Nicolaides and Gerulaka classification.
RESULTS: Results: Atherosclerotic stenoses were found in all patients of ASERP: ( 90%),- in 3.4%. AP type 1 was found in 15% of cases; 2 types - in 33.8%; 3 types - in 26%; type 4 accounted for 12.3% and type 5 accounted for 12.3% of cases. APwhich causing moderate stenosis had a high degree of embologenicity due to the hypoechogenicity and heterogeneity of atherosclerotic plaques of types I, II and III. When the level of stenosis increased, tendency to increase the density and hyperechogenicity of the AP was noted.
CONCLUSION: Conclusions: 89% patients with ASERP had non-critical, hemodynamically insignificant stenoses of the carotid arteries. Types II and III AP, mostly of an eccentric structure, dominated. Moderate stenoses were more often caused by echo-negative atherosclerotic layers, which is a source of increased embologenicity, and stenoses of a greater degree, for the most part, were echo-positive.
Obese patients who attended the First Hospital of Chongqing Medical University and intended to undergo bariatric surgery were screened according to the inclusion and exclusion criteria. Patients' basic personal information and biological specimens including blood, faeces and urine were collected for metabolic and macro-genomic analyses. Air pollution exposure of the study subjects was collected by telephone follow-up. Metabolite profiles in blood and urine were analysed using liquid chromatography-mass spectrometry (LC-MS). Microbial community composition in faecal samples was analysed using 16S rRNA gene sequencing. Metabolic and macrogenomic differences between obese and control groups were compared using t-test or Mann-Whitney U-test. Logistic regression analyses were used to assess the independent effects of different environmental factors on metabolism and macrogenome. Identify key metabolites and microorganisms associated with obesity using Random Forest and Principal Component Analysis.
FIELD: chemical industry. SUBSTANCE: dense, ultrasoft cleaning bar with neutral pH value is made from material containing, % by weight: carboxylic acids 5-50, with 20-65% of monocarboxylic acid being neutralized; anionic and/or nonionic additive imparting density to bar 20-65; water 15-55. Free monocarboxylic acids make 35-80% of mixture of free and neutralized monocarboxylic acids. pH value is 6.8-8.0. Neutralized monocarboxylic acids contain cation selected from the group involving sodium, magnesium, calcium, aluminum and their mixtures. Bar has rigid skeleton structure of crystalline phase containing interrelated open three-dimensional cells of elongate crystals mainly formed by monocarboxylic acids. EFFECT: increased efficiency, improved physical and mechanical parameter and enhanced reliability in operation.
Adenocarcinoma, HPV-independent, mesonephric type (hereafter referred to as "mesonephric carcinoma") arising from the cervix is rare, its treatment has not been established, and its sensitivity to chemotherapy has not been fully investigated. Here we report on a 30-year-old female patient who presented at our hospital with a chief complaint of abnormal genital bleeding. We suspected cervical cancer. Based on examination, biopsy, and imaging, she was diagnosed with stage IIA2 adenocarcinoma of the cervix and was scheduled for surgery. Because she had a SARS-COV-2 infection, she was given two courses of paclitaxel-carboplatin (TC) therapy, based on the then-current surgical risk assessment after SARS-COV-2 infection, with a waiting period of at least 8 weeks. The patient was deemed to have a partial response and was treated with paclitaxel and carboplatin, after which she was deemed to have a partial response and underwent total hysterectomy. A diagnosis of stage IIA2 mesonephric carcinoma, ypT1b2N0M0, was made after histopathologic examination of an excised specimen. The patient was treated with 4 additional courses of TC therapy after surgery, and has had no recurrence in 13 months. We report a first case of response to neoadjuvant chemotherapy with TC regimen in a patient with mesonephric carcinoma of the cervix.
INTRODUCTION: Vasculitides are a heterogeneous group of disorders producing inflammation of blood vessels (e.g. arteries or veins). All major vasculitides potentially have ophthalmological symptoms and signs including visual loss. Co-morbidity, multimorbidity, polypharmacy, and geriatric syndromes all play important roles in patient outcomes for these rheumatic conditions in the elderly. This monograph reviews the NCBI PubMed database (Feb 2023) literature on the neuro-ophthalmic and geriatric considerations in vasculitis.
AREAS COVERED: Cogan Syndrome, Granulomatosis with Polyangiitis, Giant Cell Arteritis, Polyarteritis Nodosa, Takayasu Arteritis, Vasculitis epidemiology, and neuro-ophthalmological symptoms.
EXPERT OPINION: Geriatric patient care for vasculitis with neuro-ophthalmological manifestations can be complicated by the interplay of multiple co-morbidities, polypharmacy, and specific geriatric syndromes. The valuation and treatment of vasculitis and the complications associated with the disease can negatively impact patient care. Advances in noninvasive imaging and updates in diagnostic criteria have enabled increased identification of patients at earlier stages with less severe disease burden. Novel therapeutic agents can be glucocorticoid sparing and might reduce the adverse effects of chronic steroid use. Holistic care models like the 5 M geriatric care model (mind, mobility, medications, multicomplexity, and matters most) allow patients' needs to be in the forefront with biopsychosocial aspects of a patient being addressed.