anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The participant is assigned to receive a flyer that includes a message emphasizing the involvement of academic researchers and a $20 incentive. Then the participant is assigned to be a message that emphasizes an individual's responsibility to their community (i.e. duty frame).
TAU plus computer assisted CBT plus placebo. All participants assigned to this condition will also be offered up to 60 minutes per week to work with the CBT for CBT program, onsite at the clinic, in a private space and using a computer provided by the research project. Patients will have the choice of how they choose to use the computer, that is, in two 30-minute sessions or one one-hour session.
Neuroinflammation, a hallmark of various central nervous system disorders, is often associated with oxidative stress and neuronal or oligodendrocyte cell death. It is therefore very interesting to target neuroinflammation pharmacologically. One therapeutic option is the use of nutraceuticals, particularly apigenin. Apigenin is present in plants: vegetables (parsley, celery, onions), fruits (oranges), herbs (chamomile, thyme, oregano, basil), and some beverages (tea, beer, and wine). This review explores the potential of apigenin as an anti-inflammatory agent across diverse neurological conditions (multiple sclerosis, Parkinson's disease, Alzheimer's disease), cancer, cardiovascular diseases, cognitive and memory disorders, and toxicity related to trace metals and other chemicals. Drawing upon major studies, we summarize apigenin's multifaceted effects and underlying mechanisms in neuroinflammation. Our review underscores apigenin's therapeutic promise and calls for further investigation into its clinical applications.
Subjects will be asked to provide a stool sample (if no colonoscopy is to be performed) or if clinically indicated, a colonoscopy will be performed per standard medical routine. During colonoscopy, stool will be collected for analysis and 3 additional biopsies will be taken each from the ileum and colon for research purposes. Alternatively, subjects who are undergoing intestinal and/or colonic resection will provide stool prior to surgery and a portion of their pathology specimens will be used for research purposes following complete pathologic evaluation.
An automated system, method or computer program product for providing visual recognition and counting of drops falling into a drip chamber for intravenous therapies (drip rate). The Automatic Visual Recognition Intravenous Infusion Drop Counting Application software subroutine framework can run on a mobile device and can be configured to, when activated, calculate and visually recognize the drip rate of intravenous therapies. The functionality of the Automatic Visual Recognition Intravenous Infusion Drop Counting Application software subroutine framework allows the user to manage standard drip sets. Additionally, different drip set values can be assigned. The Automatic Visual Recognition Intravenous Infusion Drop Counting Application software subroutine framework also allows the user to manage the infusion; application can integrate a timer and other diverse features. The updated information can be stored in the internal memory of the device, other information recording medium, a memory data storage device or into a web based storage service.
Child-caregiver dyads in the intervention group will use the mHealth app for 12 weeks with personalised nurse support via interactive communication technologies. The design of the app will be guided by the theory of unpleasant symptoms.
PROBLEM TO BE SOLVED: To prepare a pack cosmetic containing a combination of each specific two ingredients so as to limit the oil content to a specified level or lower, having good feeling with no sticky feel when applied, having moderate viscosity, spreadability and slipperiness, easy to massage, and affording fully relaxed feeling. SOLUTION: This massage cosmetic contains a combination of pref. 0.01-10wt.% (based on the whole amount of this cosmetic) of a powder ingredient with pref. 0.01-2wt.% (based on the whole amount of this cosmetic) of a water- soluble polymer so as to limit the oil content of this cosmetic to <=10wt.% (pref. 1/10wt.%). The water-soluble polymer is pref. a natural, semisynthetic or synthetic water-soluble polymer (esp. a carboxyvinyl polymer). The powder ingredient is esp. pref. silica, polyamide resin powder or polyethylene powder. The oil ingredient is pref. a hydrocarbon oil or a higher fatty acid.
The invention discloses a traditional Chinese medicine preparation for treating tourette syndrome. The disease location of the disease lies in the five internal organs, and the disease is mainly caused by liver, and has a close relation with malfunction of heart, spleen and kidney as well as internal disturbance of wind, heat and phlegm. The pathogenesis is mainly represented by spleen deficiency and hyperaction of liver Yang, endogenous phlegm, dysfunction of liftable purity and turbidity and wind phlegm agitation. According to the traditional Chinese medicine preparation disclosed by the invention, traditional Chinese medicines, including rust-brown crotalaria, broad beans, Habenaria stenostachya(lindl.)Benth, stellaria yunnanensis, radix fici simplicissimae roots, amphicome, megalanthum, Abies chensiensis Van Tiegh, gastrodia elata, roots of tall lettuce, trumpet shells and negundo chastetree fruits, which have the effects of invigorating spleen and supplementing qi, regulating the function of the liver and spleen and eliminating phlegm and calming wind are decocted into a decoction with water. Through clinical tests of the hospital, the total effective rate is 94.3% which is remarkably superior to 71.4% of the control group. The traditional Chinese medicine preparation is remarkable in curative effect.
Overconsumption of dietary sugar can lead to many negative health effects including the development of Type 2 diabetes, metabolic syndrome, cardiovascular disease, and neurodegenerative disorders. Recently, the human intestinal microbiota, strongly associated with our overall health, has also been known to be affected by diet. However, mechanistic insight into the importance of the human intestinal microbiota and the effects of chronic sugar ingestion has not been possible largely due to the complexity of the human microbiome which contains hundreds of types of organisms. Here, we use an interspecies C. elegans/E. coli system, where E. coli are subjected to high sugar, then consumed by the bacterivore host C. elegans to become the microbiota. This glucose-fed microbiota results in a significant lifespan reduction accompanied by reduced healthspan (locomotion), reduced stress resistance, and changes in behavior and feeding. Lifespan reduction is also accompanied by two potential major contributors: increased intestinal bacterial density and increased concentration of reactive oxygen species. The glucose-fed microbiota accelerated the age-related development of intestinal cell permeability, intestinal distention, and dysregulation of immune effectors. Ultimately, the changes in the intestinal epithelium due to aging with the glucose-fed microbiota results in increased susceptibility to multiple bacterial pathogens. Taken together, our data reveal that chronic ingestion of sugar, such as a Western diet, has profound health effects on the host due to changes in the microbiota and may contribute to the current increased incidence of ailments including inflammatory bowel diseases as well as multiple age-related diseases.
The invention relates to a traditional Chinese medicine composition for treatment for canine parvovirus infection, which is characterized in that the traditional Chinese medicine composition is prepared by the components with the following parts by weight by mixing: 12 to 18 parts of garden burnet root, 8 to 12 parts of golden thread, 8 to 12 parts of peach seed, 8 to 12 parts of whiteflower hogfennel root and 8 to 12 parts of membranous milkvetch root. The preferential mix ratio of the all components is as follows: 15 parts of garden burnet root, 10 parts of golden thread, 10 parts of peach seed, 10 parts of whiteflower hogfennel root and 10 parts of membranous milkvetch root. The preparation method is carried out according to the following steps: (1) the all ingredients in the formula are respectively smashed and screened by a sieve with 20 to 80 meshes; (2) 15 parts of garden burnet root, 10 parts of golden thread, 10 parts of peach seed, 10 parts of whiteflower hogfennel root and 10 parts of membranous milkvetch root are weighed according to the mix ratio by the parts by weight for even mixing. The traditional Chinese medicine composition has reasonable formula and simple preparation; the pure traditional Chinese medicine composition has no pollution, no medicine residue, low cost, broad material selection and very significant efficacy. The traditional Chinese medicine composition selects a plurality of pure traditional Chinese medicine preparations, thus having unique advantages compared with western medicines. The clinical application proves that the traditional Chinese medicine composition has special effects on canine parvovirus infection.
The present invention relates to a lymphocyte stimulating factor comprising a protein component having the ability to stimulate, in a living animal body, CD8+ T-cells resulting in the release of interferon-.gamma. (IFN-.gamma.) to elicit immunosuppression or immunostimulation in said body, wherein said protein component is selected from amino acid sequences within the sequence of amino acids numbered 1 to about 150 in Fig. 1B, which are in possession of said ability. The invention also relates to the nucleotide sequence of the lymphocyte triggering factor according to the invention as well as to a monoclonal antibody directed against said factor. Additionally, the invention relates to the use of the lymphocyte stimulating factor for medical purposes as well as to a method of treating or vaccinating a mammal in respect of African sleeping sickness.
PURPOSE:To improve solubilizing capacity of a glyceride contg. hydrogenated castor oil or hydroxystearic acid by subjecting the glyceride to glycerolysis or ester interchange reaction, then adding ethylene oxide to the reaction product. CONSTITUTION:A glyceride contg. hydrogenated castor oil or hydroxystearic acid is subjected to glycerolysis or ester interchange reaction using glycerol. After the interchange reaction, ethylene oxide is added after replacing the atmosphere with N2 at about 120-180 deg.C under atmospheric pressure - about 5atm. under stirring while blowing ethylene oxide into the glyceride. After completing the reaction, used catalyst is neutralized, and the reaction product is dehydrated at about 70-80 deg.C under reduced pressure, and filtered. By this method, an amphiphilic compsn. utilizable as emulsifier, dispersant, or solubilizer for base material of cosmetics or ointments, or blood derivatives is obtd.
HP+ participants: Lansoprazole 30 mg, capsule, orally, BID and TAK-438 placebo-matching tablet, orally, BID along with bismuth-containing quadruple antibiotic therapy for first 2 weeks. Following 2 weeks participants received Lansoprazole 30 mg, capsule, orally, QD along with TAK-438 placebo-matching tablet, orally, QD for up to 6 weeks. HP- participants: Lansoprazole 30 mg, capsule, orally, QD along with TAK-438 placebo-matching tablet, orally, QD for up to 8 weeks.
FIELD: medicine. SUBSTANCE: invention proposes method of control of proliferation of mucous cells, method of attenuation and/or treatment of injury caused by agent impairing cells. Invention relates also to lectin -containing kit and cytoprotecting agent and lectin-containing composition and cytoprotecting agent. Invention is realized due to protective properties of lectins with regards to cells of mucous tissue. EFFECT: improved method of control, valuable medicinal properties of compositions. 21 cl, 17 tbl, 5 dwg, 9 ex
PURPOSE:To provide a cosmetic effective to prevent the erythema and melanos is caused by ultraviolet radiation, and containing water-soluble extract prepared by decocting a specific vegetable crude drug with hot water or with cold mixture of water and an alcohol. CONSTITUTION:1pt. of a vegetable crude drug selected from KOKA (flower of Carthamus tinctorius), SHOKYO (rhizome of Zingiber officinale), OUBAKU (bark of Phellodendron amurense), KAIKA (flower of Sophora japonica), JIOU (root of Rehmannia glutinosa), SHAKUYAKU (root of Paeonia lactiflora), BYAKUJUTSU (rhizome of Atractylodes lancea), BOTANPI (root of Paeonia moutan), E TAKUSHA (bulb of Alisma plantago-aquatica), black tea, and green tea or an aribitrary mixture of the above crude drugs, is immersed in 8pts. of water at 80-100 deg.C, or in 8pts. of a 1:1 mixture of water and an alcohol selected from methanol, ethanol and n-propanol at 5-10 deg.C, and the obtained water-soluble extract is used as a component of a cosmetic. The extract has the activity to inhibit tyrosinase activity. Since the extract is soluble in water, it does not form a precipitate in a transparent liquid cosmetic, and can be compounded easily.
Abdominal aortic aneurysm (AAA) remains a fatal disease in the elderly. Currently, no drugs can be clinically used for AAA therapy. Considering the pivotal role of neutrophils in the pathogenesis of AAA, herein we propose the targeted therapy of AAA by site-specifically regulating neutrophilic inflammation. Based on a luminol-conjugated α-cyclodextrin material (LaCD), intrinsically anti-inflammatory nanoparticles (NPs) were engineered by simple nanoprecipitation, which were examined as a nanotherapy (defined as LaCD NP). After efficient accumulation in the aneurysmal aorta and localization in pathologically relevant inflammatory cells in rats with CaCl2-induced AAA, LaCD NP significantly alleviated AAA progression, as implicated by the decreased aortic expansion, suppressed elastin degradation, inhibited calcification, and improved structural integrity of the abdominal aorta. By functionalizing LaCD NP with alendronate, a calcification-targeting moiety, the in vivo aneurysmal targeting capability of LaCD NP was considerably enhanced, thereby affording significantly potentiated therapeutic outcomes in AAA rats. Mechanistically, LaCD NP can effectively inhibit neutrophil-mediated inflammatory responses in the aneurysmal aorta. Particularly, LaCD NP potently attenuated the formation of neutrophil extracellular traps (NETs), thereby suppressing NETs-mediated pro-inflammatory events and NETosis-associated negative effects responsible for AAA progression. Consequently, we demonstrated the effectiveness and underlying mechanisms of anti-NETosis nanotherapies for the targeted treatment of AAA. Our findings provide promising insights into discovering precision therapies for AAA and other inflammatory vascular diseases.
CAV, a rapidly progressive obliterative disease involving the graft coronary arteries, is the leading cause of morbidity and mortality beyond the first year after heart transplantation. This common complication occurs in almost half of recipients within 3 years after heart transplantation, and is associated with high rates of graft failure and mortality. Clinical care of heart transplant recipients in the current era is greatly limited by the lack of effective treatment options to prevent or retard the progression of CAV. CAV appears to be strongly associated with the state of insulin resistance, which is present in over half of heart transplant recipients and is characterized by metabolic abnormalities including glucose intolerance, dyslipidemia, endothelial dysfunction, and high levels of circulating inflammatory markers. Insulin resistance can be effectively treated with pioglitazone, a TZD compound which directly affects tissue insulin sensitivity. In this study, we will enroll 32 insulin-resistant heart transplant recipients and will randomize them to pioglitazone or placebo for a one-year period. We will determine the efficacy of pioglitazone for the treatment of insulin resistance and prevention of the development and progression of CAV after heart transplantation. The data generated from this study will provide important preliminary data for future, larger-scale clinical investigations.
Heart valve disease signifies a severe growing public health problem in developing countries, with aortic valve stenosis being the most common issue. Heart valve disease is commonly initiated by atherosclerotic degenerative processes, congenital anomalies, or rheumatic process. Aortic valve replacement is the gold standard in the treatment of patients with severe aortic stenosis and aortic regurgitation. Mechanical valves are favoured in younger patients (\<60 years) owing to longer life-time, whereas biological valves are used for elderly patients in order to evade oral anticoagulation.

Options for aortic valve disease have improved in the last era including replacement, repair, and reconstructive options. A variety of creative techniques including leaflet extensions, neo-leaflet creation, resuspension or plication of prolapsing leaflets, and commissuroplasty to repair valves have been officially become skilled at, specially in pediatric population . In adults, the introduction of trans-catheter aortic valve inserting now permits treatment of degenerative aortic stenosis in the oldest and the highest risk patients. However, surgical treatment choices for pediatric patients with complex congenital aortic valve disease stay restricted.

In recent years, much attention has been given to the Ozaki procedure, an alternative way of repairing aortic valve, involving the use of autologous pericardium for the aortic leaflet reconstruction. Diseased leaflets are removed carefully. The distance between each commissure is measured with invented sizing apparatus. The new leaflet of the size corresponding to the measured value is trimmed with an original template from glutaraldehyde-treated autologous pericardium. Finally, the annular margin of the pericardial leaflet was running sutured with each annulus. Commissural coaptation was secured with additional sutures. The coaptation of three new leaflets were always insured with direct vision.
In recent years, the role of cellular metabolism in immunity has come into the focus of many studies. These processes form a basis for the maintenance of tissue integrity and homeostasis, as well as represent an integral part of the immune response, in particular, inflammation. Metabolic adaptations not only ensure energy supply for immune response, but also affect the functions of immune cells by controlling transcriptional and post-transcriptional programs. Studying the immune cell metabolism facilitates the search for new treatment approaches, especially for metabolic disorders. Macrophages, innate immune cells, are characterized by a high functional plasticity and play a key role in homeostasis and inflammation. Depending on the phenotype and origin, they can either perform various regulatory functions or promote inflammation state, thus exacerbating the pathological condition. Furthermore, their adaptations to the tissue-specific microenvironment influence the intensity and type of immune response. The review examines the effect of metabolic reprogramming in macrophages on the functional activity of these cells and their polarization. The role of immunometabolic adaptations of myeloid cells in tissue homeostasis and in various pathological processes in the context of inflammatory and metabolic diseases is specifically discussed. Finally, modulation of the macrophage metabolism-related mechanisms reviewed as a potential therapeutic approach.
NEW MATERIAL:A compound expressed by formula I (Z represents H or glucopyranosyl) and glycoside thereof. EXAMPLE:3,4',5-Trihydroxy-6,7-(methylenedioxy)flavone-3-glycoside expressed by formula II. USE:An anti-thrombin agent. PREPARATION:A lower aliphatic alcohol extract of an indigo is subjected to chromatography. The resultant fraction eluted by methanol is further subjected to chromatography and eluted by chloroform and methanol. The obtained eluate, if necessary, is chemically treated.
A review of the use of comprehensive geriatric assessment and its components in oncology is introduced. The evidence base for the increasing incidence of cancer in the elderly worldwide also presented. The management of older adults with cancer is challenging. Comprehensive Geriatric Assessment (CGA) has been shown by many authors to be a strong predictor of adverse events in geriatric oncology patients. CGA is recommended in oncology practice for many reasons: to identify health problems not usually detected in routine oncologic screening, to perform non-oncologic interventions, and to modify the cancer treatment plan. Comprehensive geriatric assessment is the gold standard in geriatric oncology for identifying patients at high risk for adverse outcomes and optimizing cancer treatment and overall management. Nevertheless, it can be stated that the final point in the search for evidence-based and effective frailty assessment tools in the practice of geriatric oncology has not yet been reached. It is concluded that the development of new scales and index scores, as well as the application of the CGA model in general, can provide adequate care for elderly cancer patients.
Migraine is a highly prevalent neurological disorder. Alpha-asarone (ASA), a major active component found in Acorus tatarinowii, plays a crucial role in analgesia and anti-inflammation for neuropathic pain. This study aimed to assess the efficacy of ASA against migraine and elucidate its potential mechanisms using a well-established inflammatory soup (IS) migraine female rat model. Mechanical pain thresholds were assessed daily before IS infusion, followed by post-infusion administration of ASA. Subsequently, spontaneous locomotor activities, exploratory behavior, short-term spatial memory, and photophobia were blindly evaluated after the final drug administration. The rats were then sacrificed for investigation into the underlying mechanisms of action. Network pharmacology was also employed to predict potential targets and pathways of ASA against migraine. The anti-inflammatory activity of ASA and pathway-related proteins were examined in BV2 cells stimulated with lipopolysaccharides (LPS). The results demonstrated that ASA ameliorated cutaneous hyperalgesia and photophobia while improving spatial memory and increasing exploratory behavior in IS rats. ASA attenuated central sensitization-related indicators and excessive glutamate levels while enhancing GABA synthesis. ASA rescued neuronal loss in the cortex and hippocampus of IS rats. Notably, the ability of ASA to improve spatial memory performance in the Y maze test was not observed with sumatriptan, a first-line treatment drug, suggesting the potential involvement of the TLR4 pathway. Moreover, ASA suppressed microglial activation, reduced pro-inflammatory factors, and downregulated TLR4, MyD88, p-NF-κB/NF-κB, NLRP3, caspase-1, IL-1β, and IL-18. Overall, ASA demonstrated its potential to alleviate hyperalgesia and improve behavioral performance in migraine rats by inhibiting hyperexcitability and microglia-related inflammation.