anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients assigned to the ESWT group received ESWT over the plantar fascia, three days/week, for six weeks. In addition patients participated additional in the same conventional stroke rehabilitation program consisting of 60 minutes of treatment a day, five times a week for six weeks (30 sessions). The conventional therapy programs were patient-specific and consisted mainly of physiotherapy, such as neurodevelopmental facilitation techniques, passive mobilization, occupational therapy, postural control exercises, stretching and range-of-motion exercises for the hemiparetic side and balance training.
Subjects in this trial will be given denosumab every 4 weeks, starting on day 1 of study treatment. An additional loading dose of denosumab will be administered on day 8. Subjects who started Pembrolizumab (initiated 21 days after the first dose of denosumab is given) will continue to have it administered intravenously (IV) every 3 weeks. New subjects will receive Nivolumab administered intravenously (IV) every 4 weeks (initiated 21 days after the first dose of denosumab is given). Combination therapy will continue as long as subjects benefit from therapy for up to 1 year.
Anal human papillomavirus (HPV) infection has a high prevalence in men who have sex with men (MSM), resulting in an increased risk for anal cancer. The present work aimed to identify factors associated with HPV in a prospective cohort of HPV-vaccinated MSM using a random forest (RF) approach. This observational study enrolled MSM patients admitted to an Italian (sexually transmitted infection) STI-AIDS Unit. For each patient, rectal swabs for 28 different HPV genotype detection were collected. Two RF algorithms were applied to evaluate predictors that were most associated with HPV. The cohort included 135 MSM, 49% of whom were HIV-positive with a median age of 39 years. In model 1 (baseline information), age, age sexual debut, HIV, number of lifetime sex partners, STIs, were most associated with the HPV. In model 2 (follow-up information), age, age sexual debut, HIV, STI class, and follow-up. The RF algorithm exhibited good performances with 61% and 83% accuracy for models 1 and 2, respectively. Traditional risk factors for anal HPV infection, such as drug use, receptive anal intercourse, and multiple sexual partner, were found to have low importance in predicting HPV status. The present results suggest the need to focus on HPV prevention campaigns.
PURPOSE:To impart an antithrombogenic property until natural tissue is newly born, by mixing a synthetic antithrombogenic agent with a biodegradable and absorbable material in a molecular dispersion state. CONSTITUTION:A biodegradable and absorbable material and an antithrombogenic agent are mixed using an org. solvent and the resulting mixture is molded. As the biodegradable and absorbable material, polyglycolic acid, polylactic acid, poly-epsilon-caprolactone or a copolymer thereof are used. This material or copolymer composition is selected in accordance with the mechanical properties and biodegrading and absorbing speed of an objective material. As the antithrombogenic agent, a synthetic antithrombogenic agent shown by formula is used. As the org. solvent to be used, there are methylene chloride, chloroform, dimethylformamide and dioxane being a solvent of aliphatic polyester. By this method, the formation of a thrombus can be effectively suppressed over a long period of time.
A conveyor system and method that reduces extraneous forces in a manufacturing process is disclosed. The system and method of the invention are particularly directed to handling and processing sensitive materials such as, for example, in clean room manufacturing facilities. These facilities are used in the fields of semiconductor fabrication, hard disk drive manufacturing, biotechnology, biomedical engineering and pharmaceutical engineering. A conveyor system according to the invention includes a carrier and a drive assembly for providing relative movement thereto. A rib or groove extends along the bottom of the carrier parallel to the direction of travel. The rib and groove structures are also intended to reduce mechanical contact between the carrier and the drive assembly, including its components. A reduction of such contact limits the extent of contamination caused by particulate formation.
PURPOSE:To provide a monoclonal antibody, having specificity to the isozyme of the heavy chain of myocardial myosine, useful as an important reagent for the biochemical and pathological research of cardiac muscle, and enabling the topographic diagnosis of myocardial infarction. CONSTITUTION:Human atrial myosine (alpha-type) or human ventricular myosine (beta-type) immunized to a different animal, and the antibody-producing cell, e.g. immunized spleen cell, lymphonodus cell, etc. are collected. The cell strain resistant to drug, unsurvivable in a selected medium in unfused state, and survivable in fused state (preferably cell strain resistant to 8-azaguanine) is used as the myeloma cell, and fused with the antibody-producing cell at a mixing ratio of 1:4-10. The antibody-producing hybridoma is separated from the fused cell in a selected medium, and cultured e.g. in the RPMI 1,640 medium containing 10- 15% bovine fetus serum. The monoclonal antibody having specificity to only one of alpha-type or beta-type is separated from the supernatant liquid of the cultured product.
The study will consist of two parts. Patients in Part A will receive a single dose of DPC 817 on two separate occasions and a placebo (a solution or tablet without the drug) on one occasion. Patients in Part B will receive two separate doses of DPC 817. Patients will be admitted to the clinical study unit the day before dosing (Day -1) and remain there for at least 48 hours after taking the study drug. Patients will return to the clinical study unit on Day 8 and Day 28 following the dose in the last treatment period. During the study there will be medical and medication histories taken, physical examinations, vital sign measurements, and routine clinical laboratory tests.
The present invention relates to compositions and methods for improving hydration in individuals with dysphagia. More specifically, the present invention provides a method of treating or preventing dehydration in a subject suffering from impaired swallowing, such as dysphagia, the method may comprise administering to the subject suffering from dysphagia an effective amount of a composition comprising a sialagogue and a cooling agent in a weight ratio of 1:0.06 to 1: 0.2. Optionally, the composition comprises a tingling agent. The composition may be a powder that is reconstituted prior to administration, for example, at the time of drinking. The thickener or thin binder may be contained in the powder and/or may be contained in the liquid in which the powder is reconstituted. The composition may be a beverage comprising a salivator and a cooling agent, the total amount of salivator and cooling agent being at least 3.0 wt% of the beverage, such as at least 6.0 wt% of the beverage. The composition may be a ready-to-drink beverage or a frozen dessert on a stick.
The anti-tumor capacity of natural killer (NK) cells heavily relies on their ability to migrate towards their target cells. This process is based on dynamic actinrearrangement, so-called actin treadmilling, andis tightly regulated by proteins such as cofilin-1. The aim of the present study was to identify the role of cofilin-1 (CFL-1) in the migratory behavior of NK cells and to investigate a possible impact of an obesity-associated micromilieu on these cells, as it is known that obesity correlates with various impaired NK cell functions. CFL-1 was knocked-down via transfection of NK-92 cells with respective siRNAs. Obesity associated micromilieu was mimicked by incubation of NK-92 cells with adipocyte-conditioned medium from human preadipocyte SGBS cells or leptin. Effects on CFL-1 levels, the degree of phosphorylation to the inactive pCFL-1 as well as NK-92 cell motility were analyzed. Surprisingly, siRNA-mediated CFL-1 knockdown led to a significant increase of migration, as determined by enhanced velocity and accumulated distance of migration. No effect on CFL-1 nor pCFL-1 expression levels, proportion of phosphorylation and cell migratory behavior could be demonstrated under the influence of an obesity-associated microenvironment. In conclusion, the results indicate a significant effect of a CFL-1 knockdown on NK cell motility.
BACKGROUND: The Cumberland Ankle Instability Tool (CAIT) is used to screen patients with chronic ankle instability (CAI) and to quantify the severity of ankle instability. Neuromuscular deficits are common in CAI, including proprioception, strength, and balance issues. The relationship between CAIT scores and neuromuscular factors is unclear. The purpose of this study was to investigate the correlation between ankle instability and ankle muscle strength, proprioception, and dynamic balance.
METHODS: Thirty-four individuals with chronic ankle instability were included in this study. The participants' CAIT scores, muscle strength (isokinetic) and proprioception in plantarflexion (PF), dorsiflexion (DF), inversion (IV), and eversion (EV), and dynamic balance (Star Excursion Balance Test in anterior, posteromedial, and posterolateral directions) were assessed. Bivariate correlations were used to determine the relationship between CAIT scores and ankle muscle strength, proprioception, and dynamic balance.
RESULTS: In terms of muscle strength, ankle PF (r = 0.378, 95%CI: 0.046-0.635, P = 0.027) and IV (r = 0.527, 95%CI: 0.233-0.736, P = 0.001) strength were positively correlated with CAIT Score, whereas ankle DF and EV strength had no significant correlation with CAIT Score. In terms of proprioception, ankle IV proprioception (r = -0.340, 95%CI: -0.608-0.002, P = 0.027) was negatively correlated with CAIT Score, while ankle PF, DF, and EV proprioception had no significant correlation with CAIT Score. In terms of dynamic balance, the SEBT posteromedial (r = 0.444, 95%CI: 0.124-0.680, P = 0.001) was positively correlated with CAIT Score. The SEBT anterior and posterolateral were not significantly correlated with the CAIT Score.
CONCLUSION: This study found that increasing ankle plantarflexion and inversion muscle strength, improving dynamic balance in the posteromedial direction, and decreasing ankle inversion proprioceptive thresholds may help improve the subjective stability of CAI. This provides data support for targeted ankle neuromuscular function rehabilitation training for patients.
TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2100044089. Registered on 10 March 2021.
A jaundice analysis system includes a database and a processing device for accessing the database. The processing device includes: a data processing module for generating a training data according to an image data, correlating the training data with a category data, and storing the training data in the database; and a deep learning module for training a target convolutional neural network module with the training data correlating with the category data to obtain a trained convolutional neural network module. The image data includes a first sclera image. The trained convolutional neural network module of the processing device generates a testing data according to an input image data. The input image data includes a second sclera image of a target subject. The testing data indicates the target subject's bilirubin concentration range.
The current management for blunt renal injury in children is based on level 5 evidence, which is the lowest score. Essentially, empiric decisions about therapy without physiologic rationale have been permeated through generations of teaching. Patients are therefore managed by historical opinion, borrowing some principles from spleen and liver injuries. Over the past few decades all authors have agreed that non-operative management should be followed in all these patients as almost all injuries will heal with preservation of renal function. However, as opposed to spleen and liver injuries, there are no published guidelines for a non-operative management scheme. The kidney possesses important anatomic and physiologic differences when compared to the intraperitoneal solid organs that may allow for a distinct method of management. Therefore, we conducted a retrospective review to examine the natural history of these injuries and identify potential recommendations for management (IRB 07 12-186X). In patients with isolated renal injury (n = 65), mean length of bedrest was 3.8 +/- 1.9 days resulting in a mean length of stay of 3.8 +/- 3.1 days. There were no transfusions in these patients. There were 3 patients readmitted after discharge, 2 for pain control, and one for new hematuria after discharge. There were 15 patients discharged with persistent hematuria, none of whom suffered long term sequelae. Children were released from bedrest in attending-specific manner which was a wide array of management schemes. Our data suggests the risk of significant hemorrhage from blunt renal trauma is low. Further, clearance of hematuria may not be a good marker for therapy. Therefore, a period of bedrest with serial blood and urine monitoring may not be justified, and there is clearly a role for prospective application of a single management protocol to validate at least one protocol for other institutions to follow.

In the retrospective data, we found one patient developed intermittent hypertension. However, identifying this one patient requires that the hypertension is documented in our medical record, which means we may miss those patients managed by their pediatricians. More concerning is that we may be missing patients who have hypertension. These potential patients may get well into adulthood before the hypertension is detected which is why this study is imperative to define the natural history of renal healing, quantify the risk of hypertension, and potentially identify predictors of this complication.

The management protocol currently being followed and proposed for this study will include one night of bedrest and then the patient may be ambulatory the next day. From this point, patients will be managed in the hospital until they meet general discharge criteria. Discharge criteria are adequate pain control with oral pain medications and tolerating regular diet.
Carfilzomib at a dose of 20mg/m2 I.V. will be administrated at day 1, 2 post infusion of the stem cell (SC) graft to the first 10 patients. If no \> grade II toxicity\* the next 10 patients will receive Carfilzomib (27 mg/m2) at day 1,2 and 8, 9, 15 and 16. If no \> grade II toxicity\* the next 10 patients will receive 2-3 cycles of Carfilzomib (27 mg/m2) administered at day 1,2 8,9,15 and 16 post SC graft infusion.
FIELD: medicine, particularly, preparation of drug based on vegetable raw material. SUBSTANCE: drug contains dry extracts of plants including ginseng extract. The drug may be prepared in two forms: instant tablets and granulated powder. The proposed drug produces general strengthening, tonic action and reduces effect of alcohol at its acute and chronic administration for patients of various age. EFFECT: higher efficiency. 8 cl
Open-label, one arm only. All patients receiving active drug according to recommendations (adalimumab (Humira) 40 mg subcutaneously every other week).
Patients will be assigned to three dose groups:1mg, 4mg, and 8mg. Each patient will be administered NWRD06 by electroporation in entire study period. The Maximum Tolerated Dose of NWRD06 will be determined by the classical 3+3 dose escalation schedule. The number of patients will be ranged from 9 to 18.
<P>PROBLEM TO BE SOLVED: To provide a virus protein.  <P>SOLUTION: An isolated polypeptide containing a specific sequence or an immunogenic fragment thereof. Also disclosed is an isolated nucleic acid encoding the polypeptide or containing a sequence at least 70% identical to the specific sequence. Within the scope of this invention are related expression vectors, host cells, and antibodies. It is also disclosed the methods of producing the polypeptide, diagnosing coronavirus infection, and identifying a test compound for treating coronavirus infection.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely - to traumatology, physiotherapy. Method includes standard medicamentous therapy of complex regional pain syndrome. Additionally area of fracture is exposed to electromagnetic waves of terahertz range. Exposure is realised at frequency 1500.3 GHz, power density 0.2 mW/cm2, for 10 minutes. After that electromagnetic waves of said parameters are used to influence area of ganglion projection of sympathetic trunk Th2-3, Th3-4. Exposure is realised for 5 minutes. The course includes 10 procedures, carried out daily. ^ EFFECT: method reduces terms of treatment, reduces severity of clinic symptoms due to exposure to electromagnetic irradiation with frequencies of molecular spectrum of irradiation and nitrogen oxide absoption, which penetrates 5 cm deep inside tissues, producing local effect, and limits discharge of stress hormones. ^ 1 ex, 1 tbl, 3 dwg
The intervention group will undergo CT scan after 3 months. If subclinical valve thrombosis is detected, anticoagulation will be started. If no subclinical valve thrombosis is detected, the SAPT is stopped, unless another indication is present.
The observed incidence of ADAs is highly dependent on the sensitivity and specificity of the assay. Differences in assay methods preclude meaningful comparisons of the incidence of ADAs in the studies described below with the incidence of ADAs in other studies, including those of NIKTIMVO or of other axatilimab products.  
  
ADAs were assessed in 276 patients with cGVHD who received NIKTIMVO. The incidence of axatilimab-csfr treatment-emergent ADAs was 33.7% (93/276) following a median exposure time of 7.8 months. NAb were detected in 47 of 93 cGVHD patients with treatment-emergent ADAs. There was no clinically meaningful effect of anti–axatilimab-csfr antibodies or NAb on the pharmacokinetics, pharmacodynamics, or effectiveness of NIKTIMVO. The presence of NAb correlated with the occurrence of hypersensitivity reactions [see Adverse Reactions (6.1)].
A 6 week wash out period separated the LC n-3 PUFA and the Placebo (olive oil) arms. During this period the subjects took no supplements. This arm was designed to minimise a cross-over effect.
The invention refers to the production of antibodies named F5 in a cancer carrier and the effect they exert on the development of guest's tumor. F5 may down regulate the proliferation and life of cancer cells regardless the histological nature of the malignancy and the stage of tumor growth. The novel antibody may be raised exclusively in a tumor-carrier guest by challenge with the immunoglobin antigen FIV Abs. This kind of immunization imitates at a certain extent the scheme of classical vaccination with an extern pathogen justifying thus by a semantic derogation the anti-cancer therapeutic vaccination name. The uniqueness of F5 is the result of the adjustment between the conventional antigen FIV to the reactivity in cancer known as premunition. Theoretical considerations and experimental data bring evidence of the efficiency of multi clonal F5 Abs in the treatment of primary or metastatic tumors. The anticancer effect of F5 is only possible as a result of the structural mimicry of the agent with the cancer autocrine growth factors. The blocking of cancer receptors with F5 Abs may produce regression of the primary or metastatic tumors, or arrest of cancer proliferation for indefinite periods of time or, according to circumstances to reduce quantitatively the radio-chemo therapy and the extension of surgical intervention in case of necessity.
BACKGROUND: Comprehensive research on the effects of individual benzene, toluene, ethylbenzene, and xylenes (BTEX) and their mixture measured in blood samples, on cardiovascular diseases (CVD) and related risk factors among the general population is limited.
OBJECTIVES: To investigate the effects of blood individual and mixed BTEX on total CVD and its subtypes, lipid profiles, and white blood cell (WBC) count.
METHODS: Survey-weighted multivariate logistic regression was used to examine the associations between blood individual and mixed BTEX with CVD and its subtypes in 17,007 participants from NHANES 1999-2018. The combined effect of BTEX mixture on CVD was estimated using weighted quantile sum modeling and quantile g-computation. Weighted multivariate linear regression assessed the effects of BTEX on lipid profiles and WBC, including its five-part differential count.
RESULTS: In comparison to the reference quartile of BTEX mixture, individuals in the highest quartile had a significantly increased adjusted odds ratio of CVD risk (1.64, 95 % CI: 1.23 to 2.19, P for trend = 0.008). Positive associations were observed for benzene, toluene, ethylbenzene, and m-/p-xylene, demonstrating a monotonically increasing exposure-response relationship. Mixed BTEX was associated with congestive heart failure (CHF), angina pectoris, and heart attack. Individual benzene, toluene, and ethylbenzene were associated with CHF, while toluene, ethylbenzene, and all xylene isomers were linked to angina pectoris. Benzene, toluene, and o-xylene were associated with heart attack. Both mixed and individual BTEX showed positive associations with triglycerides, cholesterol, low-density lipoprotein, and WBC, including its five-part differential count, but a negative relationship with high-density lipoprotein. Subgroup analyses identified modifying effects of smoking, drinking, exercise, BMI, hypertension, and diabetes on the associations between specific toxicants and CVD risk.
CONCLUSIONS: Exposure to BTEX was associated with cardiovascular diseases and cardiovascular risk factors. These findings emphasize the importance of considering blood BTEX levels when assessing cardiovascular health risks.
OBJECTIVE: This study aims to describe and compare the prevalence of perceived barriers to physical activity (PBPA) in pre- and post-metabolic and bariatric surgery (MBS) patients and assess the association of these barriers with their physical activity levels.
METHODS: A cross-sectional study included pre-operative (n = 63) and post-operative (n = 119) groups. Sociodemographic characteristics, leisure-time physical activity levels, and PBPA data were collected. Descriptive statistics, chi-square, and Fisher's exact tests, and binomial logistic regression analyses were used for comparisons and associations.
RESULTS: Compared to the pre-operative group, the post-operative group had a lower prevalence of barriers in the physical domain (p = 0.036) and the behavioral domain (p = 0.004). However, there were no significant differences in the environmental (p = 0.531) or social (p = 0.597) domains. Pre-MBS patients were more likely to be physically inactive when perceiving barriers in the environmental (p = 0.048) and behavioral (p = 0.048) domains. In contrast, post-surgical patients were more likely to be physically inactive when perceiving barriers in the environmental (p = 0.027), social (p = 0.020), and behavioral (p = 0.037) domains.
CONCLUSION: The results show that individuals who underwent metabolic and bariatric surgery have a lower prevalence of behavioral and physical PBPA compared to those awaiting the procedure. The perception of barriers to physical activity in the environmental and behavioral domains increases the likelihood of physical inactivity in both pre- and post-MBS patients, while in the social domain, it was only associated with physical activity in post-MBS patients.
Patients eligible for an investigator initiated trial are given the standard PIS by email and are then administered a demographic data collection form, the Quality of Informed Consent Questionnaire Parts A and B, and a user feedback survey form. They will then be emailed and are also emailed a summary PIS and access to an online set of 10 video educational modules. They will then perform the QuIC-A and QuIC-B again. They will then present for their standard of care consent visit.