anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Permanent wave tip paper are impregnated with hair conditioning agents and hydrophobic components which repel the hair conditioning treatment liquids. Pref. the tip papers are impregnated e.g. with jojoba oil or various silicone oils  with various additives, perfume oils, etc. USE/ADVANTAGE - The paper are used by the hairdresser when rolling the hair during permanent waving treatment to prevent tip hair becoming bent ton the roller. The impregnated tip papers regenerate and condition hair tips already damaged by environmental factors and previous permanent waving treatments, while preventing waving treatment and thus avoiding fresh damage to the hair tips by the treatment.
<P>PROBLEM TO BE SOLVED: To solve a problem wherein the local parts of the body such as the belly and the legs are parts liable to have body fat, in the case of many persons, especially women, obesity is not favorable in terms of appearance, namely, beautification, obesity increases by factors such as change in eating habits in a modern society, chronic lack of exercise, increase in stress, etc., use of cosmetic such as gel for massage, cream, etc., mixed with a fat decomposing agent and a blood circulation promoter besides various exercises and dietary restriction is known for slimming, however, conventionally used cosmetics have strong irritation to the skin and there is almost no cosmetic having sufficient action.  <P>SOLUTION: The cosmetic having slimming action, cellulite improving action, improving action on swelling, etc., is prepared by mixing a skin care preparation with an extract of Vernonia cinerea (Linn.) Less. The cosmetic having a higher slimming action, cellulite improving action, improving action on swelling is prepared by mixing the extract of Vernonia cinerea (Linn.) Less. with fucoidan.  <P>COPYRIGHT: (C)2010,JPO&INPIT
NEW MATERIAL:A compound expressed by the formula or salt of said compound. USE:Preventive of blood coagulation. Useful for prevention of infarct of cardio- vascular system, prevention and remedy of postoperative thrombus, prevention and remedy of arterial sclerosis, etc. Has strong thrombin-inhibiting activity. PREPARATION:At first, sponge is crushed and extracted with stirring at normal temperature using >=70% ethanol. Next, resultant extract solution is concentrated at reduced pressure and separated to two layers with water and ether. Then, water layer is extracted by n-butanol, thus component migrated to butanol layer is extracted by methanol. Furthermore, methanol-soluble component is repeatedly fractionated by gel filtration and resultant active component is purified by high-performance liquid chromatography, etc.
Objective Radwisp™ is a fluoroscopic video analysis workstation recently developed to evaluate pulmonary circulation, thereby obviating the need for contrast medium or breath-holding. This study validated Radwisp as a diagnostic tool for acute pulmonary embolism (APE) and evaluated its potential utility in patients with symptoms of suspected APE. Methods The study included 10 patients (mean age, 69±16 years old) who were admitted to our hospital for suspected APE based on symptoms and physical examination findings between January 2020 and April 2021. Contrast-enhanced computed tomography (CT) and cineradiography, based on standard radiographs for the creation of a Radwisp image, were performed on the same day. Of the 10 cases of suspected APE, 7 were definitively diagnosed by CT with APE, and 3 were definitively diagnosed as not having APE. Fifty physicians (25 cardiologists and 25 residents) were blinded to patient information and CT images and asked to diagnose the presence of APE based solely on the Radwisp images. Results A total of 250 diagnoses were made by cardiologists and 250 by residents. Among the cardiologists, the sensitivity and specificity of the Radwisp-based analysis were 91% and 48%, respectively, and the positive and negative predictive values were 80% and 69%, respectively. Among the residents, the sensitivity and specificity were 88% and 35%, respectively, and the positive and negative predictive values were 76% and 55%, respectively. Conclusion This study showed an initial validation of Radwisp for diagnosing APE, revealing a high sensitivity but not yet achieving a high specificity. Further studies with a larger number of cases are needed to thoroughly evaluate the diagnostic performance.
Equal numbers of adult men and women; ages 18-75 will be recruited. Participants will report to the research unit for three visits, 1) screening and informed consent 2) study medication infusions and thermal heat testing 3) study medication infusions and thermal heat testing separated by at least 72 hours.

For study infusion visits, study participants will come to the Clinical Research Unit and one intravenous (IV) catheter will be inserted in the forearm for oxytocin infusions. Participants in this study will receive a dose of oxytocin or placebo at a steady rate for 10 minutes; one hour later, a second dose of oxytocin will be administered during one visit. During the second study infusion visit, a lower dose of oxytocin will be given by a 10-minute IV infusion and one hour later a second infusion of oxytocin at a higher dose will be given. On one study day the doses will by 0 and 1.3 micrograms (µg) and on the other study day the doses will be 0.3 and 7 µg oxytocin. The order of study days will be randomized and double-blinded. As a result, each participant will receive oxytocin doses of 0, 0.3, 1.3, and 7 µg in this double blind design.
BACKGROUND: Bicanalicular and mono-canalicular stent intubations were developed for post-oncological lacrimal duct reconstruction; however, comparative analysis between the two surgical modalities is lacking. This study aimed to compare the surgical outcomes between the two types of stents at a single institution.
MATERIALS AND METHODS: Briefly, 75 eyes of 75 patients who underwent lacrimal reconstruction combined with lacrimal stent intubation were enrolled in this study and were divided into bicanalicular stent intubation and mono-canalicular stent intubation groups. The clinical characteristics, follow-up, and prognosis were compared between the two groups.
RESULTS: Bicanalicular and mono-canalicular stent intubations were performed in 36 eyes (36 patients; Group A) and 39 eyes (39 patients; Group B), respectively. The difference in stent duration between Groups A and B was statistically significant. Three eyes in Group A and one eye in Group B experienced postoperative stent prolapse. Two eyes in Group B showed punctum stenosis and one eye had punctal ectropion. Seven eyes in Group A had canalicular slitting. There were no statistically significant differences in the mean preoperative Munk scores between the two groups. There were no statistically significant differences in the mean Munk scores and mean VAS scores at 1 week postoperatively, before stent removal, and 3 months after stent removal between the two groups.
CONCLUSION: Bicanalicular and mono-canalicular stent intubations were equally effective in ensuring lacrimal duct patency and in preventing postoperative epiphora. Appropriate cases and stent selection can reduce the incidence of postoperative complications.
FIELD: agriculture, veterinary science, virology. SUBSTANCE: invention relates to new vaccines against bursa infectious sickness in chickens produced on the basis of new attenuated viral strains deposited in ECACC. Three new strains, - MB, MB-2 and MB-1 are intermediate-pathogenic but they can not induce disease. Vaccine is produced by the following procedure: eggs with developing embryos are inoculated, embryos and membranes are collected and live vaccine is prepared from homogenate with addition of stabilizing agent. Vaccine dose is used at the range 10<SP>2</SP>-10<SP>4</SP> äê  <SB>50</SB>.. Live vaccine must contain one of viral strain or a mixture of two indicated strains, or a mixture of all indicated viral strains. Chickens vaccinated with live vaccine produce precipitating antibodies and type of specific neutralizing antibodies that show immunity to the following infection with Israel virulent bursa infectious sickness and to infection with European strain. Vaccine provides an universal immunity against bursa infectious sickness. EFFECT: improved method of preparing, enhanced effectiveness of vaccine proposed. 17 cl, 1 dwg, 7 tbl, 8 ex
Once youths are identified with a clinical high risk for psychosis (CHRp) syndrome they will begin a 2-year, 6 step intervention. They will be assessed every 6 months. If youths continue to meet CHRp criteria they will move into the next step. If they no longer meet criteria they exit the study and resume standard care. If they develop psychosis or reach the end of the 2-year intervention they can move to EDAPT, a psychosis specialty clinic or work with personnel to find a more appropriate clinical service.
The present invention relates to a novel biological material, especially to a chitosan nanometer suspension which is used for aspects of health food, external-used medical dressing, etc. and has mutation-resisting biological efficiency, and a preparing method thereof. The chitosan nanometer suspension of the invention comprises nanometer chotosan, dissolvent, Tween-80 stabilizing agent, etc. According to the invention, an appropriate amount of chitosan is selected according to the mass indexes of deacetylation degree and viscosity. The chitosan is dissolved in acetic acid and is neutralized. The product is degraded through radiation of cobalt 60-gamma ray. The degradation product is executed with after-treatments of high temperature, high pressure, ultrasonic, etc. Finally the Tween-80 stabilizing agent is added and homogenized, and the chitosan nanometer suspension can be obtained. The method of the invention has the advantages of easy operation, low cost, controllable reaction, no pollution and high product quality. The chitosan nanometer particles with good equality can be obtained. The chitosan nanometer suspension can be used as health food, external-use medical dressing, etc. The biological material researching about other biological effect can be furthermore executed.
Axial spondyloarthritis (ax-SpA) is a major cause of chronic low back pain in the young. It causes significant disability and impairs quality of life. Management of (ax-SpA) includes physical therapy along with NSAIDs, followed by TNFi or IL-17i or JAKi in refractory ax-SpA. In Bangladesh, TNFi and IL-17i are expensive, whereas Tofacitinib (JAKi) is affordable and widely used in Bangladesh. However, recent study shows that a significant number of patients, 39.4% do not meet criteria for ASDAS CRP clinically important criteria and only 26% meets the criteria for ASDAS major improvement to tofacitinib 10mg daily. 102 patients of refractory ax-SpA meeting the enrollment criteria will be taken and put on 10mg tofacitinib. Those who fail to attain ASDAS CRP major improvement criteria at 12 weeks will be put on 15mg tofacitinib and both the groups will be compared at week 24 in a dose escalation study.

No studies have been done on 15mg tofacitinib for ax-SpA, such a study will provide us ground for escalation of tofacitinib. Regarding safety issues, FDA has warned against the use of 20mg tofacitinib but not for 15mg. Baseline characteristics and variables will be recorded at initiation of therapy, 4th, 12th and 24th week. The study will take place in Rheumatology outdoor, BSMMU and Modern One Stop Arthritis Care and Research Centre, Dhaka from July 2022- April 2024. Patient's socio-demographic and clinical data will be taken in a semi-structured questionnaire. At every follow up detailed history, thorough physical examination and investigations will be done to evaluate the efficacy and adverse effects. Patients will be assessed for response, ASDAS-CRP, ASDAS-ESR, ASAS-20, BASFI, BASDAI, BASMI, ASQoL, SF-36, MASES and VAS will be noted. CBC, CRP, S. creatinine and S. ALT will be done during follow up.
The invention discloses a near infrared iridium complex chemiluminescent probe for detecting hypochlorous acid, and a preparation method and application thereof. The probe (NIRIr-CL) of the present invention consists of metallic iridium as the center, 2-methyl-3-phenylquinoxaline as the C, N ligand and one N, N ligand with oxime (C=N-OH). In this probe the oxime is able to be oxidized specifically by hypochlorous acid and to generate a strong near infrared chemiluminescent signal. On the basis, the probe and polyether F127 form a new nano probe (NIRIr-CL dots) in a self-assembly mode, and the method effectively improves the dispersibility and the chemiluminescent time of the probe under physiological conditions. The probe has excellent selectivity and sensitivity to hypochlorous acid. The method realizes chemiluminescence imaging of endogenous hypochlorous acid and exogenous hypochlorous acid of mice, and provides an effective tool for monitoring changes of hypochlorous acid in vivo.
This study targets on this newly HIV- infected cohort and urging them to receive cART in order to achieve the possible status of HIV function cure. After 3\~5 years period of treatment, cART will be discontinued after laboratory evaluation and functional cure is anticipated. These patients can achieve good life quality. In addition to elimination of the risk for HIV transmission, the cART expense of the government can be reduced on the large scale. The core of this study aims at setting up a precise and standard laboratory methodology for detecting the newly infected cases and predicting the time to stop cART. Once these assay methods are well established, they can be widely applied to assess the previous cases with long term cART for the prediction of the appropriate time to stop cART.

Thru the conventional HIV tests (within the sero-conversion stage), the detection rate of early infection is only 5-10 %. Therefore it is very desperately important to develop more tools for the diagnosis of early infection.

In addition to the standard method for detecting HIV infection, the investigators will use the HIV p24 Ag test and detuned Enzyme-linked Immunoblotting assay (EIA) assay for detecting early infection. For naïve patients, the investigators will also check the resistance testing for antiretroviral drugs in order to adjust and choose the susceptible cART for the patients. During the cART period, the investigators will follow up these patients for checking quantity of HIV RNA and proviral DNA (HIV DNA) from Peripheral blood mononuclear cell (PBMCs) in their blood. After three to five years of cART, if their HIV RNA is not detected and HIV DNA is very low, the investigators will draw the blood from the patients to isolate the Cluster of Differentiation 4 (CD4) receptors + T cells and co-cultivated with PBMCs from the healthy cohorts to evaluate the existence of HIV infectivity or not in the cART treated cases. If there is no infectivity, the investigators will stop cART. After stopping cART, the investigators will follow up these cases every six months till at least two years to check their HIV antibody, HIV RNA and HIV DNA from PBMCs to observe whether HIV recurrence occurs to them.
FIELD: medicine; medical engineering. SUBSTANCE: method involves applying absorbing bandages containing carbon mixture as sorbent. The absorbing bandage is manufactured from porous bandage material composed of viscose - 66%, polyester - 34%. The bandage is covered with sorbing material layer of carbon mixture. The carbon mixture usable as sorbent is composed of generalized graphite and carbon nanocrystals being nanotubes of 1-10 nm in size having bound radicals C, C 2 , C 3 , C 4 , C 5 , and/or radicals being one or several bound hexagonals and/or hexagonals having radicals C, C 2 , C 3 , C 4 , C 5 , attached to them. Carbon nanocrystals are added to the mixture in the amount of 10% or more. The sorbing bandage is optionally manufacturable as sterile napkin of 10x10 cm in size. EFFECT: enhanced effectiveness of treatment. 3 cl
In Part II, RO7444973 is administered IV Q3W at a fixed dose in multiple participants per dose level. Step-up dosing may also be explored.
Patients receive mirvetuximab soravtansine IV on day 1 and gemcitabine hydrochloride IV over 30 minutes on days 1 and 8. Cycles repeat every 3 weeks in the absence of disease progression or unexpected toxicity.
Participants will receive a biofeedback intervention daily for 8 weeks. Each biofeedback session lasts approximately 10 minutes.
PoNS Treatment will consist of three stages: an in-clinic training program, a home training program, and an extended home training program. During all stages of the study, subjects will complete three training sessions per day, morning, afternoon and evening, 6 days per week.
PURPOSE: To provide a novel technetium and rhenium combinable bivalent hapten usable for an in-vivo diagnostic and remedial kit. CONSTITUTION: The two hydrophilic haptens expressed by formula I (X is H, a protective group useful for protecting the effect of thiol against oxidation; R1 to R3 are the side chains of amino acid; H1 and H2 are the hydrophilic haptens) and their derivatives contg. potentially effector type groups as well as their salts; for example, S-acetyl-mercaptoacetyl-glycyl-glycyl-glycyl- N-ε-(histamine-succinyl-glycl)-lysyl-D-tyrosyl-N-ε-(histamine-succinyl-glycl)- lysineamide. The compd. of the formula I is obtd. by bringing the thiomethyl deriv. of formula II [M is a desorption group; R is R'CO (R' is alkyl, phenyl, etc.)] into reaction with the peptide deriv. of formula III. The kit and immune reagent are obtd. by incorporated this novel hapten peptide therein.
Losartan Tablets: 50mg, qd, po. QingReMoShen Granule: 12g, tid, po.
PURPOSE:An external preparation for the skin having no side effect like hormone, mildness to the skin, improved remedying effect on pimples, containing chlormadinone acetate. CONSTITUTION:An external preparation for the skin for remedying pimples, containing chlormadinone acetate such as a compound shown by the formula. The compound shown by the formula has no side effect like female hormone of sebum secretion inhibitor, no skin irritation like sulfur compound of keratin solubilizer, and improved remedying effect on pimples. An amount of the compound shown by the formula added is properly 0.001-2wt% in the external preparation for the skin. The form of the preparation is a form applicable to the skin such as cream, ointment, lotion, etc. The external preparation may be further properly blended with an antibacterial agent (e.g., hexachlorophene, phenol, etc.), vitamin A acid, photosensitizer element, etc.
Participants first received Placebo (matching Prazosin) for a 3 consecutive week period during the 7 week study period. After a washout period, they then received Prazosin. The starting dose of Prazosin (1mg capsule) will be given at Week # 5 of this arm. Symptoms will be reassessed and medication will be adjusted by 1-2 mg increments every 7 days for 3 weeks based on clinical response and severity of night mares, to achieve maximum therapeutic benefit while monitoring adverse effects using side effects scale on weekly basis (psychiatrist will be using the scale at every visit). The end point for capping the Prazosin dose will be 6 mg daily.
BACKGROUND: Tertiary lymphoid structures (TLSs) exert a crucial role in the tumor microenvironment (TME), impacting tumor development, immune escape, and drug resistance. Nonetheless, the heterogeneity of TLSs in colorectal cancer (CRC) and their impact on prognosis and treatment response remain unclear.
METHODS: The authors collected genome, transcriptome, clinicopathological information, and digital pathology images from multiple sources. An unsupervised clustering algorithm was implemented to determine diverse TLS patterns in CRC based on the expression levels of 39 TLS signature genes (TSGs). Comprehensive explorations of heterogeneity encompassing mutation landscape, TME, biological characteristics, response to immunotherapy, and drug resistance were conducted using multiomics data. TLSscore was then developed to quantitatively assess TLS patterns of individuals for further clinical applicability.
RESULTS: Three distinct TLS patterns were identified in CRC. Cluster 1 exhibited upregulation of proliferation-related pathways, high metabolic activity, and intermediate prognosis, while Cluster 2 displayed activation of stromal and carcinogenic pathways and a worse prognosis. Both Cluster 1 and Cluster 2 may potentially benefit from adjuvant chemotherapy. Cluster 3, characterized by the activation of immune regulation and activation pathways, demonstrated a favorable prognosis and enhanced responsiveness to immunotherapy. The authors subsequently employed a regularization algorithm to construct the TLSscore based on nine core genes. Patients with lower TLSscore trended to prolonged prognosis and a more prominent presence of TLSs, which may benefit from immunotherapy. Conversely, those with higher TLSscore exhibited increased benefits from adjuvant chemotherapy.
CONCLUSIONS: The authors identified distinct TLS patterns in CRC and characterized their heterogeneity through multiomics analyses. The TLSscore held promise for guiding clinical decision-making and further advancing the field of personalized medicine in CRC.
Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 susceptibility; however, underlying mechanisms remain unclear. Here, we investigated the direct effect of vaginal bacteria on HIV-1 susceptibility of vaginal CD4+ T cells. Notably, pre-exposure to Prevotella timonensis enhanced HIV-1 uptake by vaginal T cells, leading to increased viral fusion and enhanced virus production. Pre-exposure to antiretroviral inhibitors abolished P timonensis-enhanced infection. Our study shows that the vaginal microbiome directly affects mucosal CD4+ T-cell susceptibility, emphasizing importance of vaginal dysbiosis diagnosis and treatment.
PURPOSE: A composition containing rice bran extract for preventing or treating sleep disorder, anxiety, or depression is provided to reduce sleep latency and to enable long-term use without side effects such as cognitive impairment. CONSTITUTION: A pharmaceutical composition for preventing or treating deep sleep, anxiety, or depression contains rice bran extract or powder as an active ingredient. The rice extract is prepared using water, an organic solvent, or a mixture thereof. The organic solvent is low carbon number alcohol, hexane, acetone, ethyl acetate, chloroform, or diethyl ether. The rice bran extract includes an oil fraction, a liquid phase fraction, or a wax fraction of the rice bran extract. The rice extract also includes a fraction. A food composition for preventing or treating sleep disorder, anxiety, or depression contains the rice bran extract as an active ingredient. [Reference numerals] (AA) Time for sleep onset(minutes); (BB) BEE-H subfraction(250 mg/kg)
The invention provides a PY sequence short peptide and application thereof in inhibiting hERG potassium channel degradation, wherein the sequence of the short peptide is shown as SEQ ID NO. 1. The invention also provides a derivative of the PY sequence short peptide, which is a chimeric peptide formed by connecting the PY sequence short peptide and a cell penetrating peptide. The cell penetrating peptide is connected to the C terminal or the N terminal of the PY sequence short peptide. The sequence of the cell penetrating peptide is shown as SEQ ID NO. 2. An application of the PY sequence short peptide and the derivative thereof in inhibiting the degradation of the hERG potassium channel. The PY sequence short peptide designed according to the Nedd4-2 and hERG channel binding site can obviously increase I at the cellular and whole animal level Kr The effect can remarkably prevent electrophysiological reconstruction accompanied by myocardial hypertrophy, and is expected to be applied to the heart caused by pathological myocardial hypertrophyArrhythmia.