anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients undergo pelvic IMRT once daily, 5 days a week, for 5 weeks. Patients may also undergo optional nodal boost radiotherapy and/or vaginal brachytherapy boost. Patients also receive concurrent cisplatin IV over 1 hour on days 1 and 29 and bevacizumab IV over 30-90 minutes on days 1, 15, and 29. Beginning 4-6 weeks after completing IMRT, cisplatin, and bevacizumab, patients receive carboplatin IV over 1 hour and paclitaxel IV over 3 hours on day 1. Treatment with carboplatin and paclitaxel repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.
<P>PROBLEM TO BE SOLVED: To provide a wet manufacturing method of a solid powdery cosmetic that exhibits excellent sensuous properties such as smooth touch, a fitting feeling and the like and has excellent impact resistance.  <P>SOLUTION: The manufacturing method of the solid powdery cosmetic comprises the following steps 1-3. Step 1: a step of mixing a powder component with an oily component and/or a polyhydric alcohol component as a binder with stirring followed by pulverization by a crusher. Step 2: a step of forming a slurry by adding 20-100 pts.mass of a volatile solvent having a boiling point of 200°C or lower to 100 pts.mass of a base agent for the cosmetic obtained by the step 1. Step 3: filling a container with the slurry obtained by the step 2 by means of a uniaxial eccentric screw pump followed by press molding under vacuum suction and subsequently drying-removing the residual volatile solvent.  <P>COPYRIGHT: (C)2011,JPO&INPIT
PURPOSE: Compounds of the invention are useful for inhibiting thrombin and related thrombo obliteration and have structure of formula 1, for example formula 1a. Thrombin is a serine protease present in plasma in the form of prothrombin which is precursor. Thrombin plays an important role in the blood coagulation mechanism by converting fibrinogen, a plasma protein of solution state, to insoluble fibrin. CONSTITUTION: The invention includes compositions comprising the compounds of the invention in pharmaceutically allowable carriers for inhibiting platelet loss, platelet aggregation, fibrin formation, thrombus formation and embolus formation in mammals. The compositions may include anti-coagulation agent, anti-platelet agent and thrombolytic agent. The compositions may express desirable inhibiting effect by being added to blood, blood product or organs of mammals. Or the invention includes the compositions in pharmaceutically allowable carriers for preventing or treating thrombin-related diseases such as myocardial infarction, angina, temporal anemia, etc. The composition may includes certain anti-coagulation agent, anti-platelet agent and thrombolytic agent.
Disclosed is a nucleic acid construct comprising a murine SOCS-3 promoter sequence having SEQ. ID. NO.: 1, or a non-murine homologue thereof, or an operative fragment or derivative. The construct can also contain, operatively linked to the SOCS-3 promoter, a gene encoding any preselected protein, and optionally contains a reporter gene to facilitate detection and/or selection of successfully transfected cells. Also disclosed are a transgenic vertebrate cell containing the nucleic acid construct and transgenic non-human vertebrates comprising such cells. The nucleic acid construct is useful in methods of treating a growth retardation or growth acceleration disorder in a human subject and in a method of treating an autoimmune disease, immune disease, or inflammatory condition in a human subject. A kit for genetically modifying a vertebrate cell includes a polynucleotide comprising the murine SOCS-3 promoter sequence is also disclosed.
The auscultation is a non-invasive and cost-effective method used for the diagnosis of lung diseases, which are one of the leading causes of death worldwide. However, the efficacy of the auscultation suffers from the limitations of the analog stethoscopes and the subjective nature of human interpretation. To overcome these limitations, the accurate diagnosis of these diseases by employing the computer based automated algorithms applied to the digitized lung sounds has been studied for the last decades. This study proposes a novel approach that uses a Tunable Q-factor Wavelet Transform (TQWT) based statistical feature extraction followed by individual and ensemble learning model training with the aim of lung disease classification. During the learning stage various machine learning algorithms are utilized as the individual learners as well as the hard and soft voting fusion approaches are employed for performance enhancement with the aid of the predictions of individual models. For an objective evaluation of the proposed approach, the study was structured into two main tasks that were investigated in detail by using several sub-tasks to comparison with state-of-the-art studies. Among the sub-tasks which investigates patient-based classification, the highest accuracy obtained for the binary classification was achieved as 97.63% (healthy vs. non-healthy), while accuracy values up to 66.32% for three-class classification (obstructive-related, restrictive-related, and healthy), and 53.42% for five-class classification (asthma, chronic obstructive pulmonary disease, interstitial lung disease, pulmonary infection, and healthy) were obtained. Regarding the other sub-task, which investigates sample-based classification, the proposed approach was superior to almost all previous findings. The proposed method underscores the potential of TQWT based signal decomposition that leverages the power of its adaptive time-frequency resolution property satisfied by Q-factor adjustability. The obtained results are very promising and the proposed approach paves the way for more accurate and automated digital auscultation techniques in clinical settings.
Managing children with critical neurological conditions requires a comprehensive understanding of several principles of critical care. Providing a holistic approach that addresses not only the acute interactions between the brain and different organ systems, but also critical illness-associated complications and recovery is essential for improving outcomes in these patients. The brain reacts to an insult with autonomic responses designed to optimize cardiac output and perfusion, which can paradoxically be detrimental. Managing neuro-cardiac interactions therefore requires balancing adequate cerebral perfusion and minimizing complications. The need for intubation and airway protection in patients with acute encephalopathy should be individualized following careful risk/benefit deliberations. Ventilatory strategies can have profound impact on cerebral perfusion. Therefore, understanding neuro-pulmonary interactions is vital to optimize ventilation and oxygenation to support a healing brain. Gastrointestinal dysfunction is common and often complicates the care of patients with critical neurological conditions. Kidney function, along with fluid status and electrolyte derangements, should also be carefully managed in the acutely injured brain. While in the pediatric intensive care unit, prevention of critical illness-associated complications such as healthcare-associated infections and deep vein thrombosis is vital in improving outcomes. As the brain emerges from the acute injury, rehabilitation and management of delirium and paroxysmal sympathetic hyperactivity is paramount for optimal recovery. All these considerations provide a foundation for the care of pediatric patients with critical neurological conditions in the intensive care unit.
Provides occupational risk reduction training for police in 49 slides including 8 filmed videos (police officers, MDs, SSP staff, a person in recovery). The training is delivered online with secure access only for enrolled study participants.
The invention provides a kit, system and method for the preparation of porcelain dental restorations. First, second and third powders are provided in labeled containers. The first powder has a lightness value (L1) when formed into a least opaque porcelain layer. The second powder has a lightness value (L2) when formed into a less opaque ceramic layer. The third powder has a lightness value (L3) when formed into a most opaque ceramic layer. The .third lightness value is greater than the second lightness value, which is greater than the first lightness value. The lightness value differences between the third lightness value (L3) and the first lightness value (L1) are less than 2.5 CIE L*a*b units. Preferably, the first powder has a first hue (H1) when formed into the least opaque porcelain layer, the second powder has a second hue (H2) when formed into the less opaque ceramic layer, and the third powder has a third hue (H3) when formed into the most opaque ceramic layer. Preferably the first hue (H1) and the second hue (H2) are within 5 degrees of the CIE psychometric hue angle of the third hue (H3).
Patients receive cetuximab IV over 60-120 minutes for 3 weeks. Patients then undergo EBRT over 6-7 weeks. Patients achieving response continue weekly doses of cetuximab until radiation therapy is completed. Patients unable to achieve response or progression receive cisplatin IV over 1-2 hours on days 1, 22, and 43 of radiation therapy.
Atorvastatin 10mg daily for 6 months and compared to atorvastatin 40mg daily in the other arm. The primary endpoint of 6 months VH-IVUS findings and clinical outcomes would be monitored and compared.
Patients with chronic low back pain will receive verbal delivered positive instructions regarding manipulative therapy. Then, after the spinal manipulative therapy they will be submitted to a hidden conditioning procedure in which the pain threshold will be surreptitiously downgrade to conditioning pain decrease to manipulative therapy (G1).
This is a randomized controlled trial comparing the use of Narrow-Band Imaging (illumination of the colon in blue light)versus standard white light for the detection of serrated lesions in the proximal colon (the colon proximal to the splenic flexure). Recent studies have indicated that colonoscopy is more effective in preventing cancer in the left side of the colon than the right side of the colon. The reasons for this difference may be partly biologic, in that a special group of polyps known as serrated polyps, particularly sessile serrated adenomas, are located primarily proximal to the splenic flexure. These lesions share molecular features with a group of cancers that occur primarily in the proximal colon. These molecular features include CpG island methylator phenotype (CIMP) and microsatellite instability. These lesions are endoscopically subtle in that they are often flat, have the same color as the surrounding mucosa, and are hard to differentiate from normal mucosa. Narrow-Band Imaging has anecdotally been used to highlight the appearance of these lesions. This study will test whether Narrow-Band Imaging increases the detection of serrated lesions in a randomized controlled trial.
PURPOSE: We hypothesized that using a 3D-exoscope (3Dex) in microlaryngoscopic phonosurgery is non-inferior to using a standard operating microscope (OM). To compare the above, we utilized a 3Dex and an OM for microlaryngoscopic vocal fold augmentation with autologous fat in patients with glottic insufficiency and compared the procedure itself and the long-term impact of vocal fold augmentation on subjective and objective voice parameters in both groups.
METHODS: 36 patients with glottic insufficiency received microlaryngoscopic laryngeal augmentation with autologous fat. A 3Dex was utilized in 24 cases for visualization and compared to twelve cases in which an OM was used. Voice parameters were evaluated over a period of twelve months.
RESULTS: Comparison of operation time and voice parameters between the 3Dex and OM groups did not reveal significant differences. Significant improvement of mean voice quality in all parameters excluding roughness was observed at 3 and 6 months followed then by a slight decrease of voice quality parameters between the 6 and 12 months interval in both groups.
CONCLUSION: Our findings indicate no difference concerning operation time and outcome between the use of a 3Dex and an OM in phonosurgery. Our results highlight a significant voice improvement after vocal fold augmentation with autologous fat in glottic insufficiency mediated dysphonia. The smaller viewing system, better ergonomics for the primary surgeon and the assistant and a direct view for the entire surgical team make a 3Dex an interesting alternative for visualization in microlaryngoscopic phonosurgery.
With ankle replacements gaining popularity and documented good functional outcomes, there is an increasing number of patients inquiring about the possibility of converting an ankle fusion to a replacement. This could be due to pain, limited function, or increasing adjacent joint arthritis. There is an increasing body of evidence in the literature that a conversion to a replacement is possible and that the outcomes are positive. There are also absolute contradictions for a conversion. An absent fibula, pain of unknown origin, and recent infection fall in this category. Long-term follow-up is needed to see if conversions of ankle fusions to replacements have the same functional results and longevity as primary replacements.
BACKGROUND: Parvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.
CASE PRESENTATION: A 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient's symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.
CONCLUSION: The literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections.
BACKGROUND: Macromastia significantly impairs females' quality of life, with treatments such as physical therapy (PT) often providing only temporary relief. Insurance routinely denies breast reduction surgery, despite little relief after conservative treatments. Research on the efficacy of PT for macromastia is limited.
OBJECTIVES: In this study, we investigated the efficacy of PT for macromastia and identified patient factors associated with progression to surgery.
METHODS: We conducted a retrospective cohort study of patients with macromastia between 2017 and 2021. We collected data on presenting symptoms, attempted conservative treatments, PT duration, and whether surgery was performed. All patients were invited to participate in a survey regarding their symptoms, treatments, and responses to treatments. Symptoms associated with patients progressing to a breast reduction were evaluated with a multiple logistic regression.
RESULTS: Among the 327 patients identified with macromastia, 312 (95.41%) reported back pain and 272 (83.18%) attempted PT. Of the 72 (22.02%) patients who responded to the survey, 152 (46.48%) underwent subsequent surgery. The mean time from initial consultation to surgery was 283 days. Bra strap grooving was associated with progression to surgery (odds ratio = 1.90, CI = 1.02-3.54). Mean patient-reported pain levels decreased after surgery compared to after PT (pre-PT = 7.1, post-PT = 7.1, post-surgery = 3.1, P < .001).
CONCLUSIONS: Patients frequently undergo PT before breast reduction surgery despite no significant reduction in pain, whereas those who undergo surgery experience permanent relief and significantly reduced pain. Patients with bra strap grooving are more likely to progress to surgery. The requirement for PT as a prerequisite for surgery by insurance companies should be reevaluated.
Altered scapular kinematics is associated with shoulder pain. Resistance exercise is a common treatment; however, the effects of lifting an external load on scapular kinematics is limited. Understanding whether an external handheld load affects scapular kinematics in a healthy population can provide normal values utilized for comparison to individuals with shoulder pain. Currently, no studies have examined the effect of incrementally increased handheld loads. We defined the effects of varying external handheld loads on scapular kinematics during a shoulder elevation task. Healthy participants (n = 50) elevated their shoulder in the scapular plane over 4 trials. One trial of no loading (control) and 3 trials with incrementally increased external handheld loads. Scapular kinematic rotations and translations were measured during ascent and descent phases using 3D motion capture. Compared to no load, the highest external load during ascent increased scapular elevation [mean difference = 3.2 degrees (95%CI: 0.9, 5.4), p = 0.006], and during descent increased scapular elevation [mean difference = 3.9 degrees (95%CI: 2.8, 5.1), p < 0.001] and increased scapular upward rotation [mean difference = 4.5 degrees (95%CI: 2.4, 6.6), p < 0.001]. External handheld loads result in small increases in scapular elevation and scapular upward rotation. These results should be utilized as normal values to compare to individuals with shoulder pain.
Infantile hemangioma (IH) is a benign vascular tumor that occurs in 5% of newborns. The tumor follows a life cycle of rapid proliferation in infancy, followed by slow involution in childhood. This unique life cycle has attracted the interest of basic and clinical scientists alike as a paradigm for vasculogenesis, angiogenesis, and vascular regression. Unanswered questions persist about the genetic and molecular drivers of the proliferating and involuting phases. The beta blocker propranolol usually accelerates regression of problematic IHs, yet its mechanism of action on vascular proliferation and differentiation is unclear. Some IHs fail to respond to beta blockers and regrow after discontinuation. Side effects occur and long-term sequelae of propranolol treatment are unknown. This poses clinical challenges and raises novel questions about the mechanisms of vascular overgrowth in IH.
Each simulation will have between two and five participants. After consent, demographic data will be collected. Then, a study RA will fit a Magic Leap One (ML1) headsets (Magic Leap Inc., Plantation, FL) to participants. Following a scripted briefing, the instructor will also orient the participants to the ML1 headset for those in that group. After orienting the participant to the use of the headsets, the instructor will remain in a room separate from the participants, who will conduct the scenario outside. This will enable assessment of the feasibility of providing simulation instruction remotely. Prior to starting the scenario, the simulation instructor will conduct an orientation to review the core tenets of effective communication skills during prehospital care.
The present invention relates to: a pharmaceutical composition for prevention or treatment of a fatty liver disease comprising a Butyricimonas sp. strain, a culture solution thereof, a concentrate thereof, a dried product thereof, or a combination thereof as an active ingredient; a food composition for prevention or amelioration of a fatty liver disease, protection of the liver, or improvement of a liver function, comprising a Butyricimonas sp. strain, a culture solution thereof, a concentrate thereof, a dried product thereof, or a combination thereof as an active ingredient; a functional health food comprising the food composition; a feed composition for prevention or amelioration of a fatty liver disease, protection of the liver, or improvement of a liver function, comprising a Butyricimonas sp. strain, a culture solution thereof, a concentrate thereof, a dried product thereof, or a combination thereof as an active ingredient; a method for prevention or treatment of a fatty liver disease comprising a step of administering the pharmaceutical composition to a subject; uses of a composition comprising a Butyricimonas sp. strain for prevention or treatment of a fatty liver disease, protection of the liver, or improvement of a liver function; and uses of a composition comprising a Butyricimonas sp. strain for production of pharmaceutical preparations for prevention or treatment of a fatty liver disease. The composition according to the present invention inhibits accumulation of fat in the blood and fat in the liver due to a high fat diet, and exhibits the effect of protecting the liver, and thus can be utilized for prevention or treatment of a fatty liver disease.
Background: This study aimed to determine whether the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) at admission affect the transition of pediatric patients diagnosed with acute spontaneous urticaria to chronic urticaria. Methods: This study included 390 patients who presented to the Department of Pediatrics at Akdeniz University Hospital with acute spontaneous urticaria between January 2020 and December 2022. A statistical comparison was made between the hematological parameters of patients who developed chronic urticaria and those who did not. Neutrophil, lymphocyte, and platelet counts, as well as NLR, PLR, and SII ratios, were used for the comparison. Results: It was observed that acute urticaria progressed to chronic urticaria in 5.8% (n = 23) of the patients. No significant differences in lymphocyte, hemoglobin, and platelet counts were observed between the group progressing to chronic urticaria and the control group (P > 0.05). However, the chronic urticaria group had higher leukocyte and absolute neutrophil counts (P = 0.009 and P < 0.001, respectively). In addition, the NLR was significantly higher in the chronic urticaria group (P = 0.029), whereas no statistically significant difference was observed in the PLR (P = 0.180). The chronic urticaria group had a significantly higher SII than the control group (P = 0.011). Conclusion: Hematological parameters, particularly NLR and SII, may be useful indicators of the transition from acute to chronic urticaria in pediatric patients. The early identification of these markers could help monitor patients and guide treatment decisions. Further comprehensive studies are required to validate these findings.