anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: We compared the long-term outcomes of percutaneous endoscopic lumbar discectomy (PELD) with those of open fenestration discectomy (OFD) in treating lumbar disc herniation (LDH).
METHODS: 281 patients were included from January 2013 to December 2018, of whom 228 underwent PELD and 53 underwent OFD. General information of patients was collected and imbalances in covariates between groups were corrected using propensity score matching (PSM). Then, the clinical function scores, imaging data, and complications were compared.
RESULTS: Among participants, 102 patients were successfully matched and were followed for 62-128 months. Compared to the OFD group, the PELD group indicated greater improvements in visual analog scale score of low back pain (VAS-BP), Japanese orthopedic association (JOA), and Oswestry disability index (ODI) at 7 days postoperatively and the last follow-up (P < 0.05). At 24 months postoperatively and the last follow-up, the disc height index (DHI), ratio of grays (RVG), and range of motion (ROM) were higher and the compass value was lower (P < 0.05) in the PELD group compared to the OFD group, suggesting that the PELD procedure better maintained the mobility and stability of the responsible segment after surgery. The recurrence rates between the PELD (9.80%) and OFD (7.84%) groups did not reveal statistical differences (P > 0.05).
CONCLUSION: PELD and OFD both provide acceptable clinical outcomes for LDH. However, PELD is superior to OFD in terms of relieving low back pain, delaying disc degeneration, and maintaining segmental stability.
INTRODUCTION AND HYPOTHESIS: Urinary incontinence (UI) is prevalent among older women, but conservative treatment rates remain low due to limited accessibility, despite evidence supporting pelvic floor muscle training (PFMT) efficacy. Group-based approaches, including online options, could offer cost-effective alternatives. Recent evidence supports the feasibility of online group-based PFMT for treating UI in older women. This pilot study now evaluated the clinical effects of this program on the number of leakage episodes per day, additional UI-specific outcomes, and other symptoms and indicators.
METHODS: Community-dwelling women aged 65 and over, with stress or mixed UI, were recruited. Eligibility was assessed through in-person evaluations conducted by pelvic floor physiotherapists, who instructed participants on pelvic floor muscle contraction using digital palpation. Participants engaged in a 12-week group-based PFMT program with weekly 1-h sessions. Data were collected at three time points: recruitment (PRE1), before the first session (PRE2), and after the program (POST). Participants recorded UI symptoms using 7-day bladder diaries and standardized questionnaires on UI symptoms, quality of life (QoL), UI self-efficacy, and perceived costs. After the program (POST), participants provided feedback on their impression of improvement and satisfaction.
RESULTS: Participants reported a significant reduction in their number of leakage episodes per day. Standardized questionnaire scores also supported the positive effects of the program on UI symptoms and QoL, self-efficacy in avoiding leakage and performing PFMT exercises, and monthly costs for continence products. Older women expressed high satisfaction with symptom improvement and the program.
CONCLUSIONS: Online group-based PFMT improved UI symptoms, QoL, UI self-efficacy, and perceived UI costs among older women. Pragmatic randomized controlled trials are necessary for further validation.
All enrolled subjects who have not experienced an episode of acute rejection or other event resulting in removal from the study in the first 6 months after transplantation will undergo a protocol-driven biopsy at 6 months. Subjects with no clinical or histologic evidence of rejection will be eligible to be randomized and treated in a double-blinded (e.g., masked-neither subject nor health care providers will know treatment being received) fashion while continuing other immunosuppressive medications. Subjects in this arm will undergo complete steroid withdrawal by the end of 12 months post-transplant.
PURPOSE:To rapidly obtain the subject compounds containing an additional asymmetric carbon and useful for cyclotron nuclear medicine, etc., in a high yield by reacting a hydroxyl group-protected aldose with a substituted silylcyanide in the presence of a metal catalyst in a polar solvent, subsequently reducing and hydrolyzing it. CONSTITUTION:A hydroxyl-protected aldose (e.g. 2,3,4,5-di-O-isopropylidenD- arabinose) is reacted with a substituted silylcyanide (e.g. trimethylsilylcyanide) in the presence of a metal catalyst (e.g. zinc iodide) in a polar solvent (e.g. dichloromethane) with stirring at room temperatures to obtain a cyanhydrin. The resultant reaction mixture is subsequently filtered and the obtained filtrate is concentrated under a reduced pressure to recover a residue. After addition of ethyl alcohol, 30% formic acid and Raney nickel, the recovered residue is refluxed with heating for 10 min to be reduced and hydrolyzed. The resultant reaction mixture is filtered and the filtrate is concentrated under a reduced pressure. After desalting, the concentrated filtrate is purified by using the high- performance liquid chromatography, thus obtaining the objective aldose (e.g. D-mannose) containing an additional asymmetric carbon.
There are several lesions arising in the petroclival region. The most frequent tumor is the petroclival meningioma, followed by chondrosarcomas, chordomas, schwannomas of the cranial nerves V and VII, and other malignant tumors \[1, 2, 3, 4, 5\].

Petroclival meningiomas are tumors of the skull base that present a formidable challenge to surgical resection because of their deep location and relationship to vital neurovascular structures. In the majority of the cases they are benign tumors, but may involve or infiltrate the skull base bone, the dura mater, the brainstem, and all important neurovascular structures of this region. The petroclival region comprises the anatomical location of the body of the sphenoid bone, the anterior central portion of the occipital bone, and is bordered on the lateral aspect by the petrous apex. The roof of this space is formed by the petroclival ligaments and the tentorium. This space contains important neurovascular structures that are frequently involved or displaced by the tumor in a variable pattern. The basilar artery with its branches may be embedded or displaced by the meningioma. The petrosal vein is often displaced posteriorly by the tumor. Cranial nerves III and IV are usually displaced upwardly and the nerve VI is often surrounded by tumor. Petroclival meningiomas have their origin medial to cranial nerves V, VII, VIII, IX, X, and XI, and reach the tentorium . They frequently extend to the middle cranial fossa, cavernous sinus, prepontine space, and down to the foramen magnum. These tumors frequently compress the brainstem making total removal very difficult or impossible without neurologic deficits. cerebellopontine angle (CPA) and low clivus meningiomas may reach these areas. These lesions usually need different surgical approaches as transpetrosal approach ( anterior, modified and combined ) and retrosigmoid approach
FIELD: food industry. SUBSTANCE: invention relates to production of aromatic aqueousalcoholic drinks. Method involves addition to sugar syrup of essential oil, stirring mixture of sugar syrup with essential oil to form emulsion of essential oil in sugar syrup. Then alcohol is added to emulsion at stirring in the mass ratio of essential oil, sugar syrup and alcohol = (2-5): (30-55): : (40-68), respectively. Then the mixture is kept for 1.5-2 days accompanying with sugar crystallization and concentrate formation, decantation of concentrate from crystals and dilution of concentrate to required strength (4-68 vol. %) being directly after preparing and after prolonged time (up to 3 months). This allows preparing pure, clear aqueous-alcoholic drinks based on vegetable raw essential oils with improved organoleptic properties due to high content of essential oil. EFFECT: improved preparing method, simplified technological process, reduced cost. 7 cl, 1 tbl, 7 ex
This study examined the interaction between myofibrillar proteins (MPs) and the numbing substance hydroxy-α-sanshool (α-SOH) in a thermal environment, and provided an explanation of the numbness perception mechanism through muti-spectroscopic and molecular dynamics simulation methodology. Results showed that addition of α-SOH could reduce the particle size and molecular weight of MPs, accompanied by changes in the tertiary and secondary structure, causing the α-helix of MPs transitioned to β-sheet and β-turn due to the reorganization of hydrogen bonds. After a moderate heating (60 or 70 °C), MPs could form the stable complexes with α-SOH that were associated with attachment sites and protein wrapping. The thermal process might convert a portion of α-SOH' into hydroxy-β-sanshool' (β-SOH'). When docking with the sensory receptor TRPV1, the RMSD, RMSF and binding free energy all showed that β-SOH' demonstrated a low affinity, thereby reducing the numbing perception. These findings can provide a theoretical foundation for the advanced processing of numbing meat products.
PURPOSE:A liquid shampoo composition that is prepared by previously treating menthol with methylated cyclodextrin, adding the product to a shampoo composition, further preferably adding urea thereto, thus giving satisfactor coolness, when used, with its specific odor inhibited. CONSTITUTION:Menthol is previously treated with methylated cyclodextrin of the formula (n is 6-9, at least one among 3n A groups is methyl and the remainings are H) (preferably 0.05-5wt% of menthol and the amount of the cyclodextrin is 1/2-20pts.wt. per 1pt.wt. of the menthol). The product is combined with at least one of surfactants such as polyoxyethylene lauryl ether sulfate sodium salt in an amount of 5-30wt%) to give the objective shampoo composition. Further, addition of urea (3-20wt%) intensifies cool feeling of the shampoo. EFFECT:Any perfume can be freely selected and fresh coolness is given.
TGN subjects will undergo baseline endocrine and menstrual cycle evaluation, followed by intramuscular (i.m.) administration of testosterone cypionate (TC) 50 mg (standard dose) every 7 d for 32 wks (Fig. 8). After 24 wks, an aromatase inhibitor, letrozole (LET, 2.5 mg/d oral), will be co-administered with TC for 8 wks to block estrogen synthesis and examine whether T's effects are independent of E2 signaling.
The invention comprises azabenzimidazoles of the general formula: <FORM:0945147/C2/1> and their physiologically tolerable acid addition salts wherein A represents a C1-3 alkylene radical R a dialkylamino (C1-3) group or a pyndidino, piperidino, piperazino or morpholino group, R1 represents a hydrogen atom, a hydroxyl or mercapto group, a C1-5 alkoxy group or a C1-5 alkylmercapto group and <FORM:0945147/C2/2> represents an unsubstituted or nitro substituted pyridine ring.  The compounds may be prepared by subjecting an amino pyridine, containing a tertiary amino alkylamino group in a position ortho to the amino group or a substituent convertible into or replaceable by such a group, to ring closure with an alkanoic acid or a reactive functional derivative thereof such as an ester or imino ether thereof or with a carbonic or thiocarbonic acid derivative to form an azabenzimidazole ring and if necessary converting or replacing such a group. The alkanoic acid may be replaced by the alkane aldehyde or a functional derivative thereof and the product oxidised.  The compounds may also be prepared by introducing into the 1-position of an azabenzimidazole directly or in stages of tertiary amino alkyl group substituents may be introduced into the imidazole nucleus of the products or one substituent replaced by or converted into another.  The nitro group may be introduced into the pyridine ring.  2 - (b  - Diethylaminoethylamino) - 3 - amino - 5 -nitro pyridine is prepared by condensing 2-chloro-3,5-dinitro pyridine with diethylaminoethylamine to give 2-(b -diethylaminoethylamino) -3,5-dinitro-pyridine and reducing the 3- nitro group.  Similarly are prepared 2-(b -dimethylamino - ethylamino) -3-amino-5-nitropyridine and -3,5-dinitropyridine;  3-amino- and 3-nitro-4-(b -diethylaminoethylamino) - pyridines; 3-amino-and 3-nitro-4-(b -dimethylaminoethylamino) - pyridines, 3-amino- and 3-nitro-4-(b -morpholinoethylamino)-pyridines; 2-(b -diethylaminoethylamino) -3-amino- and -3-nitro-pyridines; 2-(b -dimethylaminoethylamino) -3-amino-and -3-nitro-pyridines; -4-(b -dimethylaminoethylamino) -3-amino -5-nitro- and -3,5-dinitro-pyridines. 5(6)-Nitro -7(4)-azabenzimidazole is prepared by ring closure with formic acid of 2,3-diamino-5-nitro pyridine in turn prepared by reacting 2-chloro-3,5-dinitropyridine with ammonia to give 2-amino -3,5-dinitro pyridine and reducing the 3-nitro group.  Pharmaceutical compositions comprise azobenzimidazoles of the invention in admixture with or in conjunction with a pharmaceutical carrier suitable for enteral, parenteral or topical administration. Compositions may take the form of tablets, dragees, salves, creams, solutions, suspension or emulsions and may contain other therapeutically useful substances.
BACKGROUND: The COVID-19 pandemic has profoundly affected human social contact patterns, but there is limited understanding regarding the post-pandemic social contact patterns. Our objective is to quantitatively assess social contact patterns in Suzhou post-COVID-19.
METHODS: We employed a diary design and conducted social contact surveys from June to October 2023, utilizing paper questionnaires. A generalized linear model was utilized to analyze the relationship between individual contacts and covariates. We examined the proportions of contact type, location, duration, and frequency. Additionally, age-related mixed matrices were established.
RESULTS: The participants reported an average of 11.51 (SD 5.96) contact numbers and a total of 19.78 (SD 20.94) contact numbers per day, respectively. The number of contacts was significantly associated with age, household size, and the type of week. Compared to the 0-9 age group, those in the 10-19 age group reported a higher number of contacts (IRR = 1.12, CI: 1.01-1.24), while participants aged 20 and older reported fewer (IRR range: 0.54-0.67). Larger households (5 or more) reported more contacts (IRR = 1.09, CI: 1.01-1.18) and fewer contacts were reported on weekends (IRR = 0.95, CI: 0.90-0.99). School had the highest proportion of contact durations exceeding 4 h (49.5%) and daily frequencies (90.4%), followed by home and workplace. The contact patterns exhibited clear age-assortative mixing, with Q indices of 0.27 and 0.28.
CONCLUSIONS: We assessed the characteristics of social contact patterns in Suzhou, which are essential for parameterizing models of infectious disease transmission. The high frequency and intensity of contacts among school-aged children should be given special attention, making school intervention policies a crucial component in controlling infectious disease transmission.
Liquid polyhydric alcohols are solidified by heating with wax-like or harder higher aliphatic alcohols and neutral saponaceous bodies other than soap, and allowing to cool with constant stirring.  Polyhydric alcohols specified are glycerine and ethylene, butylene, and pentamethylene glycols, diluted or not with water.  Higher aliphatic alcohols used include myristyl, palmityl, stearyl, docosyl, and myricyl, and technical mixtures of alcohols.  The neutral saponaceous bodies may be salts of sulphuric or phosphoric esters of aliphatic alcohols, or salts of condensation products of fatty acids with protalbic or lysalbic acids, e.g. stearyl lysalbic acid.  The products are neutral and are used (1) as lubricants, maybe with the addition of anti-corrosive agents; (2) as or in cosmetics or other pharmaceutical preparations.  There may be added fillers, e.g. starch, agar-agar, and dimethyl-cellulose, and, where circumstances permit, substances of acid or alkaline reaction.  In examples: (1) a cosmetic is obtained by melting down 9 lb. of myristyl alcohol with 90 lb. of glycerine on the water bath, and stirring in 1 lb. of sodium cetyl-sulphate and 10 lb. of starch; (2) an agent for pediculture is made by melting down 8 lb. of a technical mixture of palmityl and stearyl alcohols with 2 lb. of triethanolamine dodecylphosphate and 90 lb. of 80 per cent glycerine, and stirring in 2 lb. of salicylic acid.ALSO:Cosmetic and other pharmaceutical products consist of or contain liquid polyhydric alcohols solidified by heating with wax-like or harder higher aliphatic alcohols and neutral saponaceous bodies other than soap.  There may be added fillers e.g. starch, agar-agar, or dimethyl-cellulose, and, where circumstances permit, substances of acid or alkaline reaction. Polyhydric alcohols specified are glycerine and ethylene, butylene, and pentamethylene glycols.  Higher aliphatic alcohols used include myristyl, palmityl, stearyl, docosyl, and myricyl, and technical mixtures of alcohols.  Suitable neutral saponaceous bodies are salts of sulphuric or phosphoric esters of aliphatic alcohols, or salts of condensation products of fatty acids with protalbic or lysalbic acids, e.g. stearyl lysalbic acid.  In examples: (1) A cosmetic is obtained by melting in the water bath 9 lb. of myristyl alcohol with 90 lb. of glycerine, and stirring in 1 lb. of sodium cetyl sulphate and 10 lb. of starch; (2) An agent for pedicure is made by melting 8 lb. of a technical mixture of palmityl and stearyl alcohols with 2 lb. of triethanolamine dodecyl-phosphate and 90 lb. of 80 per cent glycerine, and stirring in 2 lb. of salicylic acid.
The present invention relates to conjugated peptide derivatives containing an acceptor site for glycosylation by oligosaccharyltransferase, and the use of such peptide derivatives for delivery of active agents to the lumen of the endoplasmic reticulum (ER). Therapeutic methods and compositions based on such delivery are also provided. The conjugates of the invention comprise (a) a tripeptide derivative of the formula R1-Asn-X-Y in which X is any amino acid except Pro, and Y is Ser or Thr or a derivative thereof, and R1 is an N-terminal group that is not one or more amino acids; and (b) an active agent conjugated to the tripeptide derivative. The conjugates are capable of being glycosylated by oligosaccharyl transferase, and are permeable to cell membranes until glycosylated by oligosaccharyltransferase in the lumen of the Er. In a specific embodiment, the active agent in the conjugate of the invention is an oxidizing agent, e.g. a diazene dicarbonyl covalently linked to amiloride. In another embodiment, the invention provides methods of treating cystic fibrosis, by administering a conjugate of the invention in which the active agent is an oxidizing agent.
Disparities exist in early identification of developmental disabilities, particularly for families from low-income and/or racial ethnic minority backgrounds. As WIC has frequent contact with children and families in the first five years of life, it is optimally positioned to play a unique role in early identification of developmental disabilities. However, WIC staff are not formally trained in child development outside of program's primary focus on nutrition and supporting the feeding relationship nor is formal screening for potential developmental delays an allowable WIC expense. In our prior research Oregon WIC staff reported being frequently asked by parents about potential concerns yet they also reported not being well connected to pediatric primary care, Part C Early Intervention (EI), or other resources who could further assess these concerns. In this study the investigators propose to design and pilot test a 2-part intervention to enhance the link between WIC and early childhood resources. The 2-part intervention includes: (1) WIC staff training delivered at the Local Agency which will: build staff confidence in discussing developmental concerns with families, familiarize staff with the CDC Learn the Signs Act Early (LTSAE) material which may be used to support those conversations, provide easy tips for encouraging early language and literacy development with parents, and study procedures (2) the creation of a standardized, direct, closed-loop referral process from WIC to EI for families with an identified concern who agree to the referral. EI will notify the child's primary care provider of the referral as per usual EI protocol. A referral form has been approved by the Oregon Department of Education (ODE) to support the direct referral from WIC to EI, meeting all ODE FERPA requirements. In addition, a data use agreement has been approved by ODE to allow the study team to access data on referred children to determine if they completed further assessment and the given diagnosis (if any). While our primary quantitative outcomes of interest are the number of children with a potential developmental concern who are referred directly from WIC to EI, the timing of follow-up assessment by EI from that referral, services plan \& start of services; the project really centers on improving processes between organizations who are key stakeholders in referral, assessment, and treatment. Therefore, secondary outcomes include feasibility and acceptability of the intervention amongst WIC staff, EI staff and primary care providers Upon completion of the study the investigators hope to apply our findings to scale up the WIC staff training and closed-loop referral process to take it Statewide. If successful the investigators will disseminate findings through the National WIC Association to encourage other State and Tribal WIC Authorities to adopt our procedures as best practices.
Proposed concepts aim to provide schemes, solutions, concepts, designs, methods and systems pertaining to monitoring medical devices. In particular, usage data of the medical device and other (related) medical devices is gathered. This data is used to learn normal operation values of the medical device. Accordingly, any deviations of the operation of the medical device from the normal operation values and a standard operation policy may be determined. The deviation is then used to generate an operation issue signal (i.e. a user alert, a correction action, etc.). In this way, operation issues may be automatically detected and potentially corrected at an early stage.
FIELD: medicine, stomatology. SUBSTANCE: invention proposes the use of octacalcium phosphate with maleic acid - 50 weight p. p. and 1 weight p. sodium fluoride as powdery component of composition. A mixture of ortho-phosphoric acid solution partially neutralized with aluminium hydroxide, zinc oxide as liquid component and furacilin solution (1:5000) taken at equal ratio. Filling mass is prepared by mixing powder and liquid up to paste consistence formation. EFFECT: improved quality, enhanced effectiveness of material. 4 tbl
Screening for polycystic ovary syndrome (PCOS) in antenatal care is inadequate, largely owing to the lack of clarity around whether PCOS is an independent risk factor for pregnancy complications. This systematic review and meta-analysis include 104 studies and 106,690 pregnancies in women with and without PCOS from inception until 13th July 2022. We report that women with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of miscarriage, gestational diabetes mellitus, gestational hypertension, pre-eclampsia and cesarean section are higher in women with PCOS. The increased odds of adverse outcomes in PCOS remain significant when age and BMI are matched and when analyses are restricted to high-quality studies. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured in all women who are planning to, or have recently become pregnant to facilitate prevention of adverse outcomes and improve pregnancy outcomes.