anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses a cell migration associated protein, and a coding gene and application thereof. The cell migration associated protein is a protein with one of the following amino acid residue sequences: 1) SEQ ID No. 2 in a sequence table; 2) a cell migration associated protein, wherein the cell migration associated protein is formed by substituting and/ or deleting and/or adding one or ore amino acid residue of the amino acid residue sequence of the SEQ ID No. 2 in the sequence table. The coding gene of the cell migration associated protein of the present invention can be used for constructing transgene cell models and transgene animal models for sieving medicine for preventing and/or treating diseases relevant to cell migration. The cell migration associated gene and the coding gene thereof of the present invention can also be used for preparing medicine for preventing and/or treating diseases relevant to cell migration. Meanwhile, transgene zebra fish of the cell migration associated protein expressed by specific tissue can be obtained by using tissue-specific promotors in zebra fish, and consequently, finer developmental biological research can be done.
ZnO-eugenol cements contain, in addn. to ZnO and MgO, other oxides which combine with ZnO and/or MgO. 2-20% of Ti may be added, the rest being Zn and Mg. The ratio of Mg: Ti is 0.5-15, the rest being Zn, and 3-40% of TiO2 is added, the rest being ZnO and MgO. Prepn. is by mixing and sintering the oxides. USE/ADVANTAGE - The cements have better pressure strength (300% greater than non-reinforced, and 75% greater than reinforced, commercial cements), controllable setting time, and lower water solubility (50% of that of commercial cements). The cements are used in prepn. of a metal alloy which is oxidised in the powdered state (claimed). They are used in dentistry.
A double-blind (neither the patient nor the physician know the name of the study drug), 6-month, multicenter, placebo-controlled trial to evaluate the combination of galantamine with nimodipine in patients with mixed dementia on cognition and quality of life. The target dose of galantamine is 24 mg/day and nimodipine will be taken in fixed doses of 90 mg/day. Primary outcomes will be measured by a computerized battery of neuropsychological tests and Quality of Life (QoL) scores. Secondary outcomes will be measured by ADAS-cog, Clinical Global Impression (CGI) and Neuropsychiatric Inventory (NPI). Mixed dementia (Alzheimer's Disease (AD) associated with cerebrovascular disease) is one of the most common causes of dementia, which remain largely underdiagnosed. Little is known about specific treatments for this condition. Ischemic lesions by themselves seem to play an important role in cognitive impairment, even in the presence of AD pathology. Hypotheses: - Galantamine 16-24 mg/day in combination with nimodipine 90 mg/day is superior to galantamine monotherapy (16-24 mg/day) in improving or stabilizing cognition in patients with AD associated with cerebrovascular disease (mixed dementia), as measured by the CNTB at 6 months. - Galantamine 16-24 mg/day in combination with nimodipine 90 mg/day is superior to galantamine monotherapy (16-24 mg/day) on QoL measures in this population as measured by QoL - AD at 6 months. Group 1: galantamine oral 8mg/day for a month, 16mg/day for 4 weeks and after 24mg/day until end of study plus nimodipine oral 30mg tid during all study. Group 2: Group 1: galantamine oral 8mg/day for a month, 16mg/day for 4 weeks and after 24mg/day until end of study plus placebo oral 30mg tid during all study.
It initially consisted of a five-minute warm-up, divided into two minutes of stationary marching and three minutes of jumping jacks. Subsequently, patients were instructed to climb up and down ramps, ascend and descend stairs, walk on a flat surface, and use a cycle ergometer (each task performed for five minutes). For the recovery phase, bilateral stretching of the hamstrings, rectus femoris, triceps brachii, pectoralis major, sternocleidomastoid, and scalene muscles was performed, each lasting 30 seconds per muscle. The proposed protocol was associated with the anaerobic training described in the GF (muscle strengthening group).
The walking after stroke called "hemiparetic gait" is characterized by slow and asymmetrical steps with poor motor control on the paretic leg while paradoxically increasing the cost of energy expenditure. Biomechanical evidence shows that impaired gait performance for people with chronic stroke is not solely the result of the loss of muscle strength, but involves complicated movement discoordination across multiple joints in the affected leg. This has been taken to indicate a persistent motor control deficit in the paretic leg post stroke. Recent imaging studies suggest that the persistent motor control deficit after stroke may be the result of the disruption of motor memory consolidation, a process by which a newly-learned motor skill is transformed from a fragile state to a stable state and is "saved" in our brain afterward. This indicates that the same brain area responsible for controlling motor activity is also involved in memorizing newly-learned skills during the early stage of motor learning. Presence of persistent motor control deficits in the chronic stage may be attributed to the fact that damage to the brain cortex significantly impacts the ability of acquiring motor skills and consequentially defers the improvement of motor function, including gait.
The present invention relates to a traditional Chinese medicine with medicine and food purposes for preventing and treating summer heat damp diarrhea, and a preparation method thereof. The medicine is prepared from the traditional Chinese medicine materials with medicine and food purposes, such as radish seed, Chinese mosla herb, Chinese yam, hyacinth bean, gordon euryale seed, lotus seed, job's tears seed, lotus leaf, chicken's gizzard-membrane, reed rhizome, etc., has the advantages of low production cost, no environment pollution, good mouth feel, small dosage and positive effect, is suitable for different people of different ages and is easily accepted by patients. The medicinal materials and the medicinal characteristics of the traditional Chinese medicine prescription simultaneously give consideration to the functional protection and coordination of hearts, lungs, spleens, kidneys, etc., and fully embody the whole conception and the advantages of traditional Chinese medicines. The medicine makes medicinal effects and functions more comprehensive, treats both sources and symptoms, and realizes the high bourn that the whole medicinal characteristics of traditional Chinese medicines tend to placidity and mutually raise medicinal effects. The medicine is suitable for any crowd and has wide service aspects because all medicine materials have official medicine and food purposes, positive efficacy and no toxic or side effect. The medicine has simple and uniform medication varieties and functions and flexible and various prescriptions, adapts to various patient conditions, appropriately selects medication, and widens the concrete content and the application range of identifying and treating the diseases with traditional Chinese medicines.
Neurensin-2 (NRSN2) performs a pro-carcinogenic function in multiple cancers. However, the function of NRSN2 in HPV-infected laryngeal carcinoma (LC) remains unclear. HPV transfection was performed in LC cells. The mRNA and protein levels were monitored using RT-qPCR, immunoblotting, and IF. Cell viability and proliferation were found using the CCK-8 assay and Edu staining. Cell invasion, migration, and apoptosis were probed using the Transwell, wound healing, and flow cytometry, respectively. The autophagosome was observed using TEM. NRSN2 was overexpressed in HPV-transfected LC cells. Inhibition of NRSN2 restrained the autophagy and malignant behavior of HPV-transfected LC cells. Meanwhile, the inhibition of AMPK/ULK1 pathway limited the increased autophagy of HPV-transfected LC cells caused by NRSN2 overexpression. Furthermore, NRSN2 knockdown inhibits autophagy by suppressing AMPK/ULK1 pathway, thereby restraining the malignant behavior of HPV-transfected LC cells. Our research confirmed that HPV transfection increased the autophagy and malignant behavior of LC cells by regulating the NRSN2-mediated activation of the AMPK/ULK1 pathway, offering a new target for cure of LC.
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a prominent cause of liver-related death that poses a threat to global health and is characterized by severe hepatic steatosis, lobular inflammation, and ballooning degeneration. To date, no Food and Drug Administration-approved medicine is commercially available. The Chaihu Guizhi Ganjiang Decoction (CGGD) shows potential curative effects on regulation of blood lipids and blood glucose, mitigation of organism inflammation, and amelioration of hepatic function. However, the overall regulatory mechanisms underlying its effects on NASH remain unclear.
PURPOSE: This study aimed to investigate the efficiency of CGGD on methionine- and choline-deficient (MCD)-induced NASH and unravel its underlying mechanisms.
METHODS: A NASH model of SD rats was established using an MCD diet for 8 weeks, and the efficacy of CGGD was evaluated based on hepatic lipid accumulation, inflammatory response, and fibrosis. The effects of CGGD on the intestinal barrier, metabolic profile, and differentially expressed genes (DEGs) profile were analyzed by integrating gut microbiota, metabolomics, and transcriptome sequencing to elucidate its mechanisms of action.
RESULTS: In MCD-induced NASH rats, pathological staining demonstrated that CGGD alleviated lipid accumulation, inflammatory cell infiltration, and fibrosis in the hepatic tissue. After CGGD administration, liver index, liver weight, serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) contents, liver triglycerides (TG), and free fatty acids (FFAs) were decreased, meanwhile, it down-regulated the level of proinflammatory mediators (TNF-α, IL-6, IL-1β, MCP-1), and up-regulated the level of anti-inflammatory factors (IL-4, IL-10), and the expression of liver fibrosis markers TGFβ, Acta2, Col1a1 and Col1a2 were weakened. Mechanistically, CGGD treatment altered the diversity of intestinal flora, as evidenced by the depletion of Allobaculum, Blautia, norank_f_Erysipelotrichaceae, and enrichment of the probiotic genera Roseburia, Lactobacillus, Lachnoclostridium, etc. The colonic histopathological results indicated that the gut barrier damage recovered in the CGGD treatment group, and the expression levels of colonic short-chain fatty acids (SCFAs)-specific receptors FFAR2, FFAR3, and tight junction (TJs) proteins ZO-1, Occludin, Claudin-1 were increased compared with those in the model group. Further metabolomic and transcriptomic analyses suggested that CGGD mitigated the lipotoxicity caused by glycerophospholipid and eicosanoid metabolism disorders by decreasing the levels of PLA2G4A, LPCAT1, COX2, and LOX5. In addition, CGGD could activate the inhibitory lipotoxic transcription factor PPARα, regulate the proteins of FABP1, APOC2, APOA2, and LPL to promote fatty acid catabolism, and suppress the TLR4/MyD88/NFκB pathway to attenuate NASH.
CONCLUSION: Our study demonstrated that CGGD improved steatosis, inflammation, and fibrosis on NASH through enhancing intestinal barrier integrity and alleviating PPARα mediated lipotoxicity, which makes it an attractive candidate for potential new strategies for NASH prevention and treatment.
An OX40-targeted antibody or an antigen binding fragment thereof. The OX40-targeted antibody comprises a VH. The VH comprises the following CDRs or mutants thereof: a VH CDR1 as shown in an amino acid sequence of SEQ ID NO: 10, a VH CDR2 as shown in an amino acid sequence of SEQ ID NO: 44, and/or a VH CDR3 as shown in an amino acid sequence of SEQ ID NO: 86, SEQ ID NO: 84, or SEQ ID NO: 89. Also disclosed is a preparation method, an application, and a double-antibody comprising same. The antibody or the antigen binding fragment thereof can specifically bind to OX40, promote larger activation of NF-Kb, activate OX40 pathways in vitro, and induce activation of T cell function. The double-antibody can identify tumor target TAA, can bind to OX40 on the T cell, and can recruit and activate T cells near tumor cells to kill tumor cells.
Certain embodiments of the present invention provide methods and systems for identification of most read images. Certain embodiments provide automatically determining a reading time for an image based on at least one of image viewing time and tool usage with respect to the image, and generating a viewing order for the image based on the reading time. Reading times may be determined for a plurality of images. In certain embodiments, a priority may be assigned to the image based on the reading time. Images may be arranged on a display based on the priority, for example. A series of images may be ordered according to reading time for each of a plurality of images, for example.
BACKGROUND: Various operative methods for the treatment of Morton's neuroma have been discussed, and osteotomy of the metatarsal bone has been reported recently. However, there has been no report of pedobarographic changes after metatarsal osteotomy. Pedobarographic changes of other metatarsal area after the surgery may cause transfer metatarsalgia, and thorough analysis of the pedobarographic data should be performed peri-operatively. The purpose of this study is to investigate the post-operative pedobarographic changes of sliding osteotomy of the 3rd metatarsal bone for treating Morton's neuroma.
METHODS: Forty patients (45 feet) who underwent metatarsal sliding osteotomy of the 3rd metatarsal bone for treating Morton's neuroma from November 2013 to December 2021 were retrospectively reviewed. Proximal sliding osteotomy was performed at the proximal 3rd metatarsal bone through dorsal approach. Clinical outcomes were evaluated with American Orthopaedic Foot and Ankle Society Lesser Metatarsophalangeal Interphalangeal Scale (AOFAS LMIS), Foot Function Index (FFI), and Visual Analogue Scale (VAS). Plain radiograph and pedobarogram were performed to evaluate the radiologic and pedobarographic outcomes.
RESULTS: AOFAS score was improved from 52.8 ± 9.0 (18-62) to 88.8 ± 9.8 (78-100) and FFI was improved from 61.8 ± 4.9 (50-70) to 32.2 ± 5.1 (23-42) on average. The 3rd metatarsal bone was shortened by 3.1 ± 0.8 mm and dorsally shifted by 1.5 ± 0.4 mm after the surgery. Plantar intermetatarsal distances between 2nd and 3rd and 3rd and 4th metatarsal heads were significantly increased post-operatively. Average forefoot pressure and maximum pressure of the 2nd to 4th metatarsal head were not significantly changed between pre-operatively and post-operatively.
CONCLUSION: Proximal metatarsal sliding osteotomy of the 3rd metatarsal bone shows a satisfactory result in both clinical and pedobarographical evaluations. It could be an effective treatment of permanent indirect decompression of Morton's neuroma with avoiding recurred neuroma, adhesion of tissue, paresthesia, and transfer metatarsalgia.
<P>PROBLEM TO BE SOLVED: To provide a solid powder cosmetic having impact resistance and good usability.  <P>SOLUTION: The solid powder cosmetic is produced by adding a solvent to a cosmetic base containing a powdery component and an oily component to form slurry, filling the slurry in a container and removing the solvent. The cosmetic contains 3-40 mass% spherical polyolefin resin powder having an average particle diameter of 1-50μm and 1-20 mass% nonvolatile oil component based on the whole cosmetic. The cosmetic preferably contains 5-89 mass% pearly pigment. The spherical polyolefin resin powder of the cosmetic is preferably one or more substances selected from polyethylene, polypropylene and polyethylene/polypropylene copolymer having a weight-average molecular weight of ≥3,000.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
BACKGROUND/PURPOSE: In colorectal cancer, the morphological categorization of fibrotic cancer stroma in the invasive frontal zone of the primary tumor is well reflected in the prognosis. Conversely, the histological characteristics of pancreatic cancer (PC) reveal fibrotic hyperplasia of stroma known as desmoplasia; however, its characterization is unknown. Therefore, this study aimed to evaluate the prognostic factors according to the histological categorization of desmoplastic reactions in PC.
METHODS: We retrospectively enrolled 167 patients who underwent curative resection for PC. The desmoplastic pattern was histologically classified as mature, intermediate, or immature. Clinicopathological features were evaluated, and disease-free and overall survival (OS) were analyzed in the three groups. Prognostic factors were assessed using univariate and multivariate analyses.
RESULTS: In total, 19 mature, 87 intermediate, and 61 immature desmoplastic patterns were evaluated. Jaundice decompression, white blood cell count, and platelet/lymphocyte ratio were significantly different among the groups. The mature group had a better disease-free survival (DFS) prognosis than the other two groups; however, OS did not differ between the groups. Desmoplastic patterns showed significant differences between the three groups for DFS.
CONCLUSIONS: Desmoplastic patterns are a prognostic factor of DFS for PC, with mature desmoplastic reactions associated with good prognosis. Thus, they may aid in individualized therapeutic approaches in patients with PC.
PURPOSE: To obtain a composition containing a short-chain oligopeptide having sequence having defined motif and capable of modulating an immune system in vitro or in vivo. CONSTITUTION: Immune system of a mammal host containing B-cell and T cell is brought into contact with a polypeptide having substantially same amino acid sequence as amino acid sequence of notable immunogen and containing an oligopeptide having about 9-15 amino acid groups containing motif comprising one charged amino acid (e.g. aspartic acid, lysine or arginine), two hydrophobic amino acid groups (e.g. alanine, proline or leucine) and subsequent two amino acid groups whose at least one is polar amino acid (e.g. charged amino acid, serine or threonine). Thereby, immune response of immune system of mammal host containing B-cell and T-cell to the immunogen is modulated. A sequence similar to motif of endogenic protein, especially neuroprotein is excluded from the above polypeptide.
Anti-angiogenic therapy has long been used as an adjunct therapy for the resolution of tumor burden. The current findings describe the synthesis of novel marine-based azirine-containing compounds that exhibit anti-angiogenic mediated anti-tumor activity. Azirine-2-carboxylate inhibited HUVEC-mediated tubulogenesis without causing cell death in a dose-dependent manner. Ex-vivo CAM, in-vivo Matrigel implantation, and ear angiogenesis experiments have all shown that azirine-2-carboxylate effectively inhibits angiogenesis. Furthermore, azirine-2-carboxylate inhibits the migration of ECs without disrupting the preformed tubule network. Azirine-2-carboxylate had adequate intramuscular systemic exposure and inhibited tumor growth in a xenograft mouse model. DARTS analysis, competitive binding assay, and gene expression investigations revealed that azirine-2-carboxylate inhibits endothelin-1-mediated angiogenesis. Overall, the discovery of azirine-2-carboxylate demonstrated a potent inhibition of angiogenesis targeting ET1 and a possible application in anti-angiogenic therapy.
PURPOSE:To obtain a tasteless and odorless ingredient for the bath useful for keeping the health by the economical method, by drying the leaves, stems, etc. a water oat in the sun to a semidried state, crushing the leaves, stems, etc. steaming the crushed fragments, fermenting the steamed fragments in a chamber, drying the fermented the fragments completely in the sun, and finely pulverizing the dried fragments. CONSTITUTION:The leaves, stems and root of a water oat collected from a marsh are dried in the sun to a semidried state, and finely crushed to a suitable size and washed. The resulant crushed fragments are steamed at about 100 deg.C for a suitable time, naturally cooled and stored in a box with vent holes and fermented. The fermented fragments are then dried in the sun finally to a completely dried state and finely pulverized or the resultant fine powder is dissolved in water to give an aqueous solution usable as an ingredient for the bath. Hot water containing the ingredient assumes green color and gives a refreshing feeling, and various nutrient components and vitamins of the water oat are absorbed through the sin, et. rapidly. The ingredient is effective for neuralgia, rheumatism, oversensitiveness to the cold, etc.
Adipose tissue and skeletal muscle dysfunction play a central role in cardiometabolic morbidity. Ashwagandha and Andrographis are purported to have anti-inflammatory and antioxidant activity, but this is based on exposure of cells to the parent compounds ignoring phytochemical absorption and metabolism. We explored the anti-inflammatory/antioxidant effects of ashwagandha and Andrographis in ex vivo human models of skeletal muscle and adipose tissue. Healthy participants supplemented with 2000 mg/day Andrographis (n = 10) or 1100 mg/day ashwagandha (n = 10) for 28 days. Sera collected pre (D0) and post (D28) supplementation were pooled by timepoint and added to adipose explant (AT) and primary human myotube (SKMC) culture media (15% v/v) for treatment. A Taqman panel of 56 genes was used to quantify these. In AT, treatment with ashwagandha sera decreased the expression of genes involved in antioxidant defence and inflammatory response (CCL5, CD36, IL6, IL10, ADIPOQ, NFEL2, UCP2, GPX3, GPX4; geometric 95% CI for fold change > 1) and altered the expression of genes involved in fatty acid metabolism. In SKMC, ashwagandha sera altered FOXO1 and SREBF1 expression. Andrographis sera decreased IL18 and SERPINEA3 expression in AT. This physiologically relevant in vitro screening characterises the effects of ashwagandha in AT to guide future clinical trials.
PURPOSE:To obtain the subject derivative remarkably improved in antibacterial activity and useful as an antibacterial agent for Gram-positive bacteria, aerobic bacteria and mycoplasma by introducing a hydroxyl group into a double bond at 2-3 position of the lactone ring of an antibiotic kanamycin. CONSTITUTION:A carbonyl group at 9 position of an antibiotic kanamycin produced by Micromonospora griseorubida A11725 (Bikoken stipulation No. 705) and represented by formula I (A is a single bond or oxygen atom; Me is methyl) is reduced by an alkaline borohydride so as to be converted to a hydroxyl group. A silylation agent composed of a compound represented by the formula (R1R2R3Si)3CuLi [R1 and R2 are each a lower alkyl; R3 is a lower alkoxy or a substituted)phenyl] is subsequently reacted therewith so as to introduce a silyl group into 3 position. The hydroxyl group at 9 position of the resultant compound is then oxidized to be returned to a carbonyl group. Further, the silyl group at 3 position is oxidatively eliminated in the presence of fluorine ions, thus affording the objective mycinamicin derivative represented by formula II.
Patients eligible for implant processor renewal in 2 years and corresponding to inclusion criteria will be enrolled during their routine check-up appointment at the implantation reference centers of the University Hospitals of Montpellier and Toulouse. Patients will be their own controls through the use of their medical history data.