anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a pharmaceutical composition for preventing or treating colon cancer, containing Sox2 as an active component. More specifically, Sox2 overexpressed in a colon cancer cell can activate the expression of ATG10 by binding to a promoter of ATG10 which is a gene inducing autodigestion. The ATG10 activated by the Sox2 induces the autodigestion of the colon cancer cell. The autodigestion induced by the ATG10 effectively increases the extinction of a cell by generating vacuole within a cancer cell and activating a lysosome action. The ATG10 controls the proliferation and division of the cancer cell by inducing the aging of the cancer cell, thereby inhibiting the growth of a tumor. In addition, a composition including the Sox2 reduces side effects occurring in the treatment of the cancer and increases the extinction of the cancer cell by selectively inducing autodigestion for the colon cancer cell without affecting a normal cell, thereby preventing or treating the colon cancer.
Home based aerobic exercise on cycle ergometer. Three times per week, 30-60 minutes per session.
BACKGROUND: We aimed to investigate the association between DNA-methylation biological age (B-age) calculated as age acceleration (ageAcc) and key aneurysmal subarachnoid haemorrhage (aSAH) complications such as vasospasm, delayed cerebral ischaemia (DCI), poor outcome, and mortality.
METHODS: We conducted a prospective study involving 277 patients with aSAH. B-age was determined in whole blood samples using five epigenetic clocks: Hannum's, Horvath's, Levine's and both versions of Zhang's clocks. Age acceleration was calculated as the residual obtained from regressing out the effect of C-age on the mismatch between C-age and B-age. We then tested the association between ageAcc and vasospasm, DCI and 12-month poor outcome (mRS 3-5) and mortality using linear regression models adjusted for confounders.
RESULTS: Average C-age was 55.0 years, with 66.8% being female. Vasospasm occurred in 143 cases (51.6%), DCI in 70 (25.3%) and poor outcomes in 99 (35.7%), with a mortality rate of 20.6%. Lower ageAcc was linked to vasospasm in Horvath's and Levine's clocks, whereas increased ageAcc was associated with 12-month mortality in Hannum's clock. No significant differences in ageAcc were found for DCI or poor outcome at 12 months with other clocks.
CONCLUSIONS: Our study indicates that B-age is independently associated with vasospasm and 12-month mortality in patients with aSAH. These findings underscore the potential role of epigenetics in understanding the pathophysiology of aSAH-related complications and outcomes.
The persistent infection of high-risk human papillomavirus (HPV) and the progression of cervical cancer necessitate the involvement of microenvironmental immunity. As cervical lesions advance, there is an observed increase in the infiltration of type 2 (M2) macrophages. However, the precise mechanism driving this increased infiltration of M2 macrophages remains unclear. In this study, we investigated the role of exosomes in polarising M2 macrophages in cervical lesions associated with HPV E6. Through the analysis of bioinformatics data and clinical specimens, we discovered a positive correlation between HPV E6/E7 mRNA copy number and the level of M2 macrophage infiltration. Exosomes derived from HPV E6 overexpressed (HPV E6+) cervical squamous cell carcinoma (CESC) cells were found to induce the polarisation of macrophages towards M2 type. Specifically, miR-204-5p, enriched in HPV E6 + CESC exosomes, was transported into macrophages and triggered M2 macrophage polarisation by inhibiting JAK2. The clinical relevance of exosomal miR-204-5p in the progression of cervical lesions was validated through serum samples from 35 cases. Exosomal miR-204-5p emerges as a critical factor influencing M2 macrophage polarisation and is correlated with the severity of cervical lesions. Consequently, miR-204-5p could be used as a potential treatment and a candidate biomarker for cervical lesions.
The present invention belongs to the technical field of health care wine, particularly to a cordial for nourishing bodies, which is made from rose and Chinese caterpillar fungus. The cordial is prepared from two production methods, and has a technological process: screening and cleaning of raw materials, ingredient leaching, clarification and filtration, blending and ageing, checking and fine filtration, filling and stabilization, and checking for obtaining the cordial. The raw materials for producing the cordial comprises edible wine, rose, raspberry, dandelion, pawpaw, honeysuckle flower, chrysanthemum flower, ganoderma and aweto, wherein the edible wine is white wine and yellow wine. The present invention has one method that the raw materials are leached together, and has the other method that the ganoderma and the aweto are separated and leached by the edible wine. The alcoholicity of the wine is from 6 to 45%<v>/v. The present invention provides a novel cordial for nourishing bodies for the society, has the functions for promoting qi, activating blood circulation to dissipate blood stasis, expulsing toxin and keeping youthfulness, and has the advantages of simple and convenient production technology, easy control, less investment, low production cost, and good economical and social benefit.
To address the problem of large deformations in weak surrounding rock tunnels under high ground stress, which cause damage to initial support structures, this study proposes a novel type of circumferential pressure-relief joint based on the concept of relieving deformation pressure of the surrounding rock. Key parameters of the pressure-relief joint, such as initial bearing capacity peak, constant bearing capacity, and allowable pressure-relief displacement, were obtained through numerical simulations and laboratory experiments. A comparison was made between the mechanical characteristics of rigid joints and the new type of pressure-relief joint. The applicability of the pressure-relief joint was verified through field tests, monitoring the surrounding rock pressure, internal forces in the steel frames, and the convergence displacement of the support structure. The results show that: (1) In the elastic stage, the stiffness of the new pressure-relief joint is similar to that of rigid joints. In the plastic stage, rigid joints fail directly, whereas the pressure-relief joint can control deformation and effectively release the deformation pressure of the surrounding rock while providing a constant bearing capacity. (2) The right arch foot in the experiment had poor rock quality, leading to high stress in the steel frame and significant horizontal displacement. After the deformation of the pressure-relief joint, the stress in the surrounding rock and steel frame significantly reduced, and the rate of horizontal deformation of the support structure slowed down. (3) The vertical and horizontal final displacements of the pressure-relief joint in the experiment were 61mm and 15mm, respectively, which did not exceed the allowable deformation values. The components of the support structure remained intact, ensuring safety. However, this study has limitations: the design of the new pressure-relief joint only allows for a vertical deformation of 150mm and a horizontal deformation of 50mm, limiting the range of pressure-relief deformation.
The occurrence of brain hemorrhage (germinal matrix hemorrhage and intraventricular hemorrhage, GM-IVH) in newborns, especially in preterm infants, is one of the most important prognostic factors for mortality and morbidity (especially for later neurological development) in this collective. The risk of high-grade bleeding in extremely premature infants (22 weeks) is approx. 38% and decreases to approx. 7% by the 28th week. The total frequency of GM-IVH is around 8% in gestational weeks 23 to 31, with each additional gestational week reducing the risk by 3.5%. The etiopathology of brain hemorrhage is complex and involves both environmental and genetic factors. Recent studies particularly suggest an involvement of the immature coagulation system in preterm neonates. Global coagulation parameters, such as the International Normalized Ratio (INR), have already been associated with an increased risk of bleeding, but rarely show fluctuations outside the norm. Furthermore, polymorphisms in the area of individual coagulation factors as well as other inflammatory and vascular individual components of coagulation, are associated with an increased risk of bleeding. Mass spectrometry has long been used for the analysis of biological samples and has developed into an indispensable tool for proteomics research. The study aims to establish the mass spectrometric detection of a total of 125 blood plasma factors containing the individual components of the coagulation system and the complement system. The method enables quantitative detection of the coagulation system with even the smallest sample quantities, so that sampling can be combined with routine measures, particularly in the field of neonatology. This pilot study to compare the compositional differences regarding coagulation factors and the complement system in relation to the gestational age (i.e. preterm ≤32+0 weeks vs. term neonates ≥37+0 weeks).
FIELD: medicine. 
     SUBSTANCE: invention refers to medicine, particularly to devices and methods of subcutaneous injections of medical products. An injection needle with the pointed working end with its point presenting a surface generated with an exponential of rotation about the longitudinal axis, interfaced with a cylindrical body, lies on the longitudinal axis of the needle with a central passage and round-edged side holes. The total sectional area of the holes is equal to the sectional area of the needle passage. The holes are double paired, opposed and inclined 45° to the longitudinal axis of the needle. The row displacement is 90°. The external surface of the needle represents smooth longitudinal diametrical corrugations with flute depth that makes 0.2 of the external diametre of the needle, completely coated with a layer of porous gelatine with the uniform external diametre of the layer. The layer thickness in the thinnest places is 0.2 of the external diametre of the needle. The method of subcutaneous injection includes alcohol preparation of a desired skin area. This skin area is folded with the left hand. The fold shall be triangular with its base downwards. The second finger of the right hand holds the injection needle, the fifth finger of the right hand holds the piston, and the other fingers of the right hand hold the cylinder. The needle is quickly inserted into the triangle base at the angle 45° at the depth 1-2 cm between the first and the second fingers of the left hand. The solution is slowly injected, and the needle is quickly removed. Then the injection point is wiped with alcohol with pressing thereto a sterile alcohol-wetted cottonwool tampon for a short time. After alcohol preparation, the skin area is heated up to +42°C. Before folding the skin, the fingers are heated to +42°C. Immediately prior to the injection the needle is dipped in 96° ethyl alcohol at temperature lower than 30°C. The chosen medical product is dissolved with an equal volume of 0.9% sodium chloride and heated to +42°C and injected in amount 0.5 ml and less. Alcohol for tampon wetting is heated to +42°C. The tampon is pressed until complete ultrasound-aided exsanguination of tissues within medicinal infiltrate with applying gel and the sensor heated to +42°C, during 6 minutes. If introduction of greater volume is needed, new injections are made, at least 1 cm away from each other. 
     EFFECT: invention prevents postinjection bruises with lowered blood coagulation ensured by accelerated occlusion of the involved vessels. 
     2 cl, 2 ex
FIELD: medicine, gastroenterology. SUBSTANCE: one should use suspension of fetal cells additionally subjected to, at least, 2-fold irradiation with laser radiation. Suspension of fetal cells of liver and/or spleen and/or thymus should be injected intraperitoneally. The method increases content of biologically active substances in fetal tissue that accelerates hepatic regeneration processes. EFFECT: higher efficiency of therapy. 2 cl, 3 ex
Participants will be fit with Oticon OPN™ behind-the-ear hearing aids with the Omni-directional microphone system enabled. Participants are to use the hearing aids at least an average of 8 hours per day over the course of 6-8 months.
This study is an open-label, prospective, multi-center study on the use of PBM as a treatment for visual impairment in subjects with dry AMD. Subjects diagnosed with dry AMD who meet all inclusion criteria and have none of the exclusion criteria will be eligible to participate in this clinical study. All subjects will be treated with the Valeda Light Delivery System and will receive PBM treatment for a total of 9 treatments over a three to five-week period (3 times per week for 3 weeks is preferable). There will be a re-treatment period starting at the 4-month time point to include 9 additional treatment visits, to be repeated again at 8 months and 12 months. LumiThera will use settings for the 3 wavelengths that were used in the CSP005 study. The subject population for this study will consist of all subjects that completed the CSP005 study, meet the inclusion/exclusion criteria for the CSP010 study, are interested in study participation and have signed the Informed Consent Form.
Provided in the present invention are an aggregate and a preparation method therefor, and an insulin oral preparation. Specifically provided is an aggregate, which is an aggregate formed by means of assembling a chalcogen heterocyclic compound and insulin. The aggregate can be further prepared into an insulin oral preparation. The oral preparation can be used for reducing the blood glucose level of a mammal as part of a diabetes treatment regimen. The chalcogen heterocyclic compound in the insulin oral preparation prepared by means of the method can effectively protect insulin against the three physiological barriers of an oral uptake pathway, is stable in the gastrointestinal tract environment, is subjected to a dynamic chemical exchange reaction with intestinal mucin in intestinal juice and the sulfhydryl groups of proteins inside and outside an epithelial cell membrane by means of the molecular bond of polychalcogen on the surface, and enters the circulation system from the intestinal epithelial cell to achieve the effect of reducing blood glucose. When being orally administered, the insulin oral preparation has high bioavailability, has a good hypoglycemic effect in mammals, and can be used for treating diabetes.
FIELD: medicine. SUBSTANCE: new medicinal agent consists of a mixture of equal amounts of heparin and chitosan sulfoester at viscosity 0.2-0.4 dl/g and sulfur content 13.0-15.0% and exhibits direct anticoagulating effect. At intravenous administration new agent provides decrease of heparin consumption and its hemorrhagic action at the retained antithrombic and anticoagulant activities. Agent can be used for thrombosis prophylaxis and treatment. EFFECT: enhanced effectiveness of agent. 5 tbl
Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 109/l after the exclusion of other conditions associated with thrombocytopenia. We investigated the role of different memory T-cell subsets, including T stem cell memory (TSCM), in children diagnosed with primary ITP and its association with therapeutic duration. This case-control study included 39 pediatric patients with acute ITP admitted to the Children's Hospital at Assiut University. Using a FACSCanto flow cytometer, CD8 + and CD4 + T-lymphocytes were gated. Five different subsets were characterized in each of these cells according to CD45RO and CD45RA expression. Afterward, gating was performed based on CCR7, CD95, and CD27. Examination of the CD8 + T cells subpopulation showed that Central memory T (TCM) and CD8+ Naïve T (TN) cells were significantly lower in ITP patients than in healthy children (p < 0.0001) and (p = 0.01), respectively. In addition, CD8 + TEMRA was significantly higher in ITP children than in controls (p = 0.001). CD4 + TCM cells were significantly lower in the ITP patient group (p = 0.04). However, CD4 + TEM was significantly higher in patients than controls (p = 0.04). Our research found that ITP patients had an imbalance in the ratio of CD4+ to CD8+ T cells in the peripheral blood and that TCM cells may be involved in the pathogenetic mechanism of ITP. TCMs could help in prediction of patients with higher risk of developing ITP.
Once each patient has signed the informed consent document and it has been verified that the inclusion criteria are met, it will be assigned the same identification number (ID) that is related to its Clinical History (CH) by simple coding; custody of the file with the relationship of each ID with its CH will be the responsibility of the principal investigator. Patients admitted to the Guadarrama Hospital with the diagnosis of stroke and who meet the eligibility criteria will be treated by their usual physiotherapist, who will administer the standard dry needling intervention plus standard physiotherapy treatment or only standard physiotherapy treatment as a function of being trained and qualified to administer dry needling.

Patients will receive 6 sessions of DNHS® (Dry Needling for Hypertonicity and Spasticity) technique with an interval of 1 week between each session (1st to 4th sessions) and every 15 days (5th and 6th sessions). The procedure will be applied according to the corresponding protocols established in the NWPs (Normalized Work Plans) used in the usual clinical practice in the Guadarrama Hospital. All patients (both groups) will receive standard daily physiotherapy treatment for the affected arm according to the NWPs used in the Guadarrama Hospital.

The DNHS® technique is specifically indicated for the treatment of spasticity. This technique differs from that usually used to relieve pain and deactivate myofascial trigger points (MTPs). The muscles to be treated are placed in a submaximum stretching position; the evaluation criteria when defining the needle insertion zone are based on finding an increase in modularity and muscle activity in the area when the muscle undergoes rapid stretching. Once the area to be treated is located, the needle is inserted and moves between 0.5 and 1 cm in / deep and fan out / surface to cause a local or global spasm reaction. Treatment ceases when the frequency of these responses decreases markedly or disappears. If the patient feels "not tolerable" pain (some discomfort from the dry needling is usual), you can stop the treatment at any time. Before and after each dry needling session or standard physiotherapy treatment patients will be evaluated by an independend assessor blinded to intervention , using the upper limb block of the Fugl-Meyer scale that assesses motor skills and sensitivity of the affected arm, evaluation of pain through NRS10 and assessment of spasticity of muscles to be treated by MMAS. Also, at the beginning, in the 4th session and at the end of the study, the Euro-QoL 5D 5L quality of life survey will be administered, with a license for use. In addition BSS and ULP will be evaluated at the beginning and at the end of the study. In each dry needling session, the caliber of the needle used, the number of fast-in and fast-out of the needle and the number of the spasm reactions caused for the purpose of establishing the dose pattern shall be recorded for each treated muscle.
This study will be a randomized clinical trial and will be conducted in Al-Khidmat Foundation Sahiwal. The study will be completed within the time duration of six months. A nonprobability convenience sampling technique will be used to collect the data. The sample size of 30 patients will be taken in this study, aged 20-to 50 years, will be allocated to two groups, Group A (Jones technique) and Group B (cross friction massage). Strain counter strain technique also known as the Jones technique will be performed with the patient laid supine on the treatment table, taking them to a position of comfort by extending, side-bending, and rotating the head away (ESARA) from the TP until the TP pain has reduced. Continues to monitor, maintaining the patient's position for 90 seconds. After 90 seconds have elapsed, the patient's head should be slowly and passively returned to a neutral position with 3 sessions/week for 6 weeks.

Group B will get cross friction massage for 15-20 minutes. Participants will be treated 3 times per week for 6 weeks. Pre and Post-treatment readings will be taken in 1st session and 6th week respectively. Assessment will be done via a 6-item Headache Impact scale and neck disability index. The Neck Disability Index will be used to examine neck pain intensity and cervicogenic headache symptoms. The 6-item Headache Impact Test scale will be used to examine headache severity and its adverse effects on social life and functions. A goniometer will be used to assess the rotation range of motion.
PURPOSE:To prepare microcapsules with shells high in mechanical strength in  which enveloped core material is fixed excellently, by impregnating microcapsule  base material, which is formed from a photocrosslinkable high molecular cpd. as  shell and does not envelope core material, with core material soln., then irradiating the base material with light. CONSTITUTION:A photocrosslinkable high molecular cpd. is made by introducing a hydrophobic photosensible group (e.g., cinnamoyl group) to a hydrophilic high molecular cpd. such as PVA. The high molecular cpd. is then dissolved into an org. solvent (e.g., CHCl3) to form 0.01-10 wt.% soln. To the soln. is added water or aq. solvent and is stirred violently so as to be emulsified. Microcapsules diposited at the interface between the dispersion medium and the liq. drops, and enveloping solvent inside are separated. The microcapsules are impregnated with a core material (e.g., enzime, pharmaceuticals) soln. in order to make the core material infiltrate through shells into inside. The microcapsules enveloping the core material is irradiated with light in order to photo crosslink the high molecular cpd., which constitutes the shells through the photo-crosslinkable group.
Preoperative oral carbohydrate loading is an issue that has been investigated extensively in terms of its fundamental and biochemically apparent effects and potential benefits. Most commonly, proponents of the application advocate that it may be beneficial for improving patient outcomes and for decreasing complication rate by attenuating postoperative insulin resistance. To date, however, no study with a sufficient sample size has been able to demonstrate that it has a marked value in clinical practice. Almost all of the clinical benefits ascribed to the application have been based on subjective well-being, which can also be provided with non specific simple beverages. A study conducted to show whether or not the application has direct influence on patient outcome, therefore, could significantly contribute insights on this topic. The present study was planned to consist of three study arms, namely: 1.Study group, which will be given high-carbohydrate beverage (Nutricia preOp®, Numico, Zoetermeer, The Netherlands) 2. Placebo group, which will be given flavored water, and 3. Control group (surgery after overnight fast). The revised power analysis shows that an accrual of 74 patients in each group would allow detecting a 15% difference in the rate of complications with 80% power at the 5% level of significance (two tailed). We hope we will have recruited at least 220 subjects at the end of a two-year course. Once the data recording is complete, this study will be the largest one ever conducted to investigate this topic.