anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Embodiments of the present invention disclose a method for medical image data sharing based on a cloud platform, and the cloud platform and a system for medical image data sharing. The cloud platform is connected with at least one medical image device. The method comprises receiving medical images and/or scanned data sent by the at least one medical image device, and then storing the medical images and/or scanned data of the at least one medical image device on the cloud platform. According to the embodiments of the method, the cloud platform and the system, sharing of medical images and/or scanned data between all the medical image devices connected with the cloud platform can be realized. Further, a process of medical image reconstruction can be realized on the cloud platform side, so that the efficiency of reconstruction progress of the medical images is improved. Further, support is provided for fusion of medical images and/or scanned data of medical image devices in different types. Further, the security of the medical images and/or the scanned data can be improved through permission setting.
OBJECTIVE: The aim of this study is to scrutinize the prognostic significance of inflammatory biomarkers concerning the effectiveness and safety of combining PD-1 inhibition with chemotherapy in the management of advanced NSCLC.
METHODS: We conducted a retrospective analysis involving 206 NSCLC patients who received treatment at Qingdao Municipal Hospital. The study encompassed the acquisition of baseline clinical attributes and hematological parameters of these patients. The optimal threshold values for PLT and NLR were ascertained based on pre-treatment evaluations, with a particular focus on their association with PFS. Variables linked to PFS were subject to scrutiny through Kaplan-Meier analysis and logistic regression. The Receiver Operating Characteristic (ROC) curve served as the means to determine the ideal cut-off values for categorizing levels of inflammatory markers into high and low classifications. We employed Chi-square tests to evaluate the relationship between elevated and reduced baseline levels of inflammatory markers and irAE.
RESULTS: Kaplan-Meier analysis disclosed that patients in the low baseline PLT group and the low NLR group exhibited a substantially more favorable prognosis in contrast to their counterparts in the high baseline PLT and high NLR groups. Multivariate analysis indicated that diminished baseline PLT and NLR levels before treatment independently foretell extended PFS. Chi-square analysis underscored a substantial correlation between baseline WBC, NEUT, LYMPH, MONO, and NLR levels and irAE.
CONCLUSION: Subdued baseline PLT and NLR levels may serve as indicators of a more auspicious prognosis in patients contending with advanced NSCLC undergoing the combination of PD-1 inhibition and chemotherapy. Elevated baseline levels of inflammatory markers antedating PD-1 therapy in advanced NSCLC may be intimately interrelated with the occurrence of irAE.
Triamterene and hydrochlorothiazide combines triamterene, a potassium-conserving diuretic, with the natriuretic agent, hydrochlorothiazide.

Each Triamterene and Hydrochlorothiazide 37.5 mg/25 mg Tablet, USP contains 37.5 mg of Triamterene, USP and 25 mg of Hydrochlorothiazide, USP.

Each Triamterene and Hydrochlorothiazide 75 mg/50 mg Tablet, USP contains 75 mg of Triamterene, USP and 50 mg of Hydrochlorothiazide, USP.

Triamterene and hydrochlorothiazide tablets for oral administration contains the following inactive ingredients: lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. In addition, the 37.5 mg/25 mg tablets contain D&C Yellow No.10 Aluminum Lake and FD&C Blue No.1 Aluminum Lake. 

Triamterene is 2,4,7-triamino-6-phenylpteridine. Triamterene is practically insoluble in water, benzene, chloroform, ether and dilute alkali hydroxides. It is soluble in formic acid and sparingly soluble in methoxyethanol. Triamterene is very slightly soluble in acetic acid, alcohol and dilute mineral acids. The following is the structural formula:

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H -1,2,4, benzothiadiazine-7-sulfonamide 1,1-dioxide. Hydrochlorothiazide is slightly soluble in water and freely soluble in sodium hydroxide solution, n-butylamine and dimethylformamide. It is sparingly soluble in methanol and insoluble in ether, chloroform and dilute mineral acids. Its molecular weight is 297.73. The following is the structural formula:
The invention relates to a health monitoring data monitoring method and a health monitoring system for postpartum patients, which are used for collecting health data and recovery indexes of the patients through ward terminals and medical care terminals, so that unified collection, processing and display of the data are realized. The ward terminal is equipped with various sensors, an image acquisition module, a body fluid detection module, a physiological parameter monitor, a wearable device for tracking action parameters and user interaction equipment, and is used for comprehensively monitoring the physical condition of a patient. Through unique image processing technology and body fluid spectrum analysis, the wound healing and body fluid status of a patient are accurately obtained. The system adopts patient ID binding to ensure accurate correspondence of data. The data is automatically stored in the database, and the data processor analyzes and generates a recovery index, and the recovery index is displayed on the medical care terminal in real time, so that medical staff can conveniently check and retrieve various health data at any time. The system provides user questionnaire input to further enrich the health data sources. The whole scheme realizes the omnibearing and refined monitoring of the health condition of the postpartum patient.
BACKGROUND: To investigate the effect of different working periods on missed diagnoses in patients with colorectal polyps in colonoscopy.
METHODS: We conducted a retrospective analysis of patients who were diagnosed with colorectal polyps during colonoscopy in an outpatient department between July and December 2022. These patients were subsequently hospitalized for resection during this period. Patients with missed diagnoses were those who had newly discovered polyps in a second colonoscopy. The working periods were categorized as work, near the end of work, and delayed work, respectively, in the morning and afternoon.
RESULTS: A total of 482 patients were included, and the miss rate of diagnosis was 48.1% (232/482), mainly in the transverse colon (25%), and the ascending colon (23%). Patient age was a risk factor for the miss rate of diagnosis (OR = 1.025, 95%CI: 1.009-1.042, P = 0.003) and was also associated with the number of polyps detected for the first colonoscopy (χ2 = 18.196, P = 0.001). The different working periods had no statistical effect on the missed rate of diagnosis (χ2 = 1.998, P = 0.849). However, there was an increasing trend in miss rates towards the end of work and delayed work periods, both in the morning and afternoon. The highest miss rate (60.0%) was observed during delayed work in the afternoon. Additionally, poor bowel preparation was significantly more common during delayed work in the afternoon.
CONCLUSIONS: The increasing trend in miss rates towards the end of work and delayed work periods deserves clinical attention. Endoscopists cannot always stay in good condition under heavy workloads.
The relationship between circulating metabolites and sarcopenia-related phenotypes remains unclear. We explored the causality between circulating metabolites and sarcopenia-related phenotypes. Instrumental variables for the human metabolome were derived from the recently published GWAS, which included 690 plasma metabolites. Summary statistics for four sarcopenia phenotypes (whole-body lean mass (WBLM), usual walking pace, appendicular lean mass (ALM), and handgrip strength (HGS)) (both sexes, males and females) were obtained from relevant GWASs. We used MR to evaluate the association between circulating metabolites and sarcopenia-related phenotypes. Colocalization analysis was utilized to determine whether two associated signals were consistent with a shared causal variant rather than the confounding effect of linkage disequilibrium. Subsequently, we explored associations between modifiable risk factors and sarcopenia-related metabolites to explore which metabolites may serve as potential intervention targets through lifestyle modification. Genetically predicted plasma levels of 95 known metabolites were associated with sarcopenia-related phenotypes, and 27 metabolites were supported by robust evidence of colocalization, among which 13 metabolites had a cross-sarcopenia effect. These metabolites primarily included acyl carnitines, amino acids and their derivatives, and phospholipids. Specifically, our analyses supported causal relationships between 23, 6, and 15 metabolites and ALM, HGS, and WBLM, respectively. Seven relevant metabolites might be associated with six modifiable factors. We identified 27 metabolite biomarkers with robust causal evidence for sarcopenia-related phenotypes, highlighting 13 metabolites with a cross-sarcopenia effect, and prioritized several metabolites as the potential interventional targets of lifestyle changes. Our study provided new insight into the etiology and prevention of sarcopenia.
PROBLEM TO BE SOLVED: To provide a solid powdery cosmetic for the eyebrows having excellent effects on production of a three-dimensional appearance of the eyebrows without a sense of incompatibility, uniformly loosened with a small tool such as a brush during use and having good lasting quality of makeup. SOLUTION: This solid powdery cosmetic for the eyebrows is characterized as comprising the following ingredients (a) and (b). (a) fibers and (b) an oil- repellent oil having perfluoroalkyl groups. The solid powdery cosmetic for the eyebrows is characterized in that the ingredient (a) is staple fibers having <1.5 mm length and <5 denier fineness. This solid powdery cosmetic for the eyebrows is characterized in that the ingredient (a) is filaments having >=1.5 mm length and >=5 denier fineness. Furthermore, any of the solid powdery cosmetics for the eyebrows are characterized in that the ingredient (a) contains the staple fibers and the filaments. Any of the solid powdery cosmetics for the eyebrows are characterized in that the ingredient (a) contains the staple fibers and the filaments in a mass ratio within the range of (1:9) to (9:1).  Any of the solid powdery cosmetics for the eyebrows are characterized in that the surface of the ingredient (a) is treated with a fluorine compound.
Patients who qualify for the core phase of the study will be treated with pasireotide LAR 40 mg initially. Patients not achieving biochemical control can be up-titrated to pasireotide LAR 60 mg.
Aspects of the present disclosure include G6PD-modulating agents and methods for modulating a glucose-6-phosphate dehydrogenase (G6PD) in a sample using such agents. A G6PD-modulating agent can be dimeric and include two terminal carbocyclic or heterocyclic groups connected via a linker. In some instances, the agent includes a diamino-containing linker. In certain cases, the agent includes two amino substituents. Also provided are methods for treating a subject for a G6PD deficiency-associated condition, that include administering to a subject an effective amount of a G6PD-modulating agent to selectively activate a mutant G6PD and treat the subject. Kits and compositions for practicing the subject methods are also provided.
PROBLEM TO BE SOLVED: To obtain the subject preparation capable of reducing the side effects of a methotrexate analogue and improving the compliance of a patient and having a systemic therapeutic effect for the treatment of a chronic inflammatory disease by including the methotrexate analogue in a specific ratio. SOLUTION: This preparation contains a methotrexate analogue (excluding methotrexate) having a structure of the formula (R<1> is hydrogen, CF3 or the like) in an amount of 0.001-30 wt.%, preferably 0.01-20 wt.%. The methotrexate analogue includes 3,5-dichloromethotrexate. The base agent of the preparation preferably contains a percutaneous absorption-stimulating agent, such as an alcohol or an organic acid, in an amount of 0.1-50 pts.wt. per 100 pts.wt. of the total amount of the base agent. The objective preparation can be prepared in the preparation form of ointment, cream, percutaneous absorption cataplasm, etc. The preparation is especially useful for chronic articular rheumatism.
Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses causally associated with 5% of human cancers, comprising both anogenital and upper aerodigestive tract carcinomas. Despite the availability of prophylactic vaccines, HPVs continue to pose a significant global health challenge, primarily due to inadequate vaccine access and coverage. These viruses can establish persistent infections by evading both the intrinsic defenses of infected tissues and the extrinsic defenses provided by professional innate immune cells. Crucial for their evasion strategies is their unique intraepithelial life cycle, which effectively shields them from host detection. Thus, strategies aimed at reactivating the innate immune response within infected or transformed epithelial cells, particularly through the production of type I interferons (IFNs) and lymphocyte-recruiting chemokines, are considered viable solutions to counteract the adverse effects of persistent infections by these oncogenic viruses. This review focuses on the complex interplay between the high-risk HPV oncoproteins E6 and E7 and the innate immune response in epithelial cells and HPV-associated cancers. In particular, it details the molecular mechanisms by which E6 and E7 modulate the innate immune response, highlighting significant progress in our comprehension of these processes. It also examines forward-looking strategies that exploit the innate immune system to ameliorate existing anticancer therapies, thereby providing crucial insights into future therapeutic developments.
PURPOSE:To prepare a peculiar antibody to vanylmanderic acid, by a method wherein bovine serum albumin is chemically bonded to vanylmanderic acid to impart immunogenicity thereto and, after an animal is innoculated with the resulting conjugate, blood is collected from said animal and the specific antibody is separated from the blood and purified. CONSTITUTION:Vanylmanderic acid is dissolved in a saline solution and 1-ethyl- 3, 3-dimethylaminopropyl hydrochloride and bovine serum albumin are added to said solution. This reaction solution is applied to column chromatography using Sephadex G-25 to separate a conjugate of vanylmanderic acid and bovine serum albumin. In the next step, a rabbit is hypodermically innoculated with the resulting conjugate as a protein concn. along with a Freund's complete adjuvant and, thereafter, blood is collected from the rabbit. Whereupon, the production of a peculiar antibody to vanylmanderic acid is discovered in the serum of the blood. This specific antibody is separated and purified by affinity chromatography prepared by coupling AH-Cephalose 4B with vanylmanderic acid.
The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.
Participants in the intervention group engaged in a 8-week yoga program delivered at their place of work (IT companies). Sessions were group-based, prescribed three sessions per week during break time (30-mins).
Fleshy fruits become more susceptible to pathogen infection when they ripen; for example, changes in cell wall properties related to softening make it easier for pathogens to infect fruits. The need for high-quality fruit has driven extensive research on improving pathogen resistance in important fruit crops such as tomato (Solanum lycopersicum). In this review, we summarize current progress in understanding how changes in fruit properties during ripening affect infection by pathogens. These changes affect physical barriers that limit pathogen entry, such as the fruit epidermis and its cuticle, along with other defenses that limit pathogen growth, such as preformed and induced defense compounds. The plant immune system also protects ripening fruit by recognizing pathogens and initiating defense responses involving reactive oxygen species production, mitogen-activated protein kinase signaling cascades, and jasmonic acid, salicylic acid, ethylene, and abscisic acid signaling. These phytohormones regulate an intricate web of transcription factors (TFs) that activate resistance mechanisms, including the expression of pathogenesis-related genes. In tomato, ripening regulators, such as RIPENING INHIBITOR and NON_RIPENING, not only regulate ripening but also influence fruit defenses against pathogens. Moreover, members of the ETHYLENE RESPONSE FACTOR (ERF) family play pivotal and distinct roles in ripening and defense, with different members being regulated by different phytohormones. We also discuss the interaction of ripening-related and defense-related TFs with the Mediator transcription complex. As the ripening processes in climacteric and non-climacteric fruits share many similarities, these processes have broad applications across fruiting crops. Further research on the individual contributions of ERFs and other TFs will inform efforts to diminish disease susceptibility in ripe fruit, satisfy the growing demand for high-quality fruit and decrease food waste and related economic losses.
[ 18F]FDG uptake may be changed by fasting or by blood sugar changes associated with diabetic mellitus. Blood glucose levels should be stabilized in non-diabetic patients by fasting before [ 18F]FDG injection. Diabetic patients may need stabilization of blood glucose on the day preceding, and on the day of the [ 18F]FDG scan. 

Patients should be monitored for arrhythmias and other manifestations of ischemia. [ 18F]FDG, CIDG and their metabolites theoretically could inhibit glucose metabolism. Their ability to potentiate the arrhythmogenic effects of ischemia has not been studied. 

The contents of each vial are sterile and non-pyrogenic. To maintain sterility, aseptic technique must be used during all operations involved in the manipulation and administration of [ 18F]FDG. 

[ 18F]FDG should be used within 12 hours of the end of synthesis (EOS). 

As with any other radioactive material, appropriate shielding should be used to avoid unnecessary radiation exposure to the patient, occupational workers, and other persons.

Radiopharmaceuticals should be used only by physicians who are qualified by specific training in the safe use and handling of radionuclides.
Background: Symptoms of dyspepsia are usually encountered by chronic kidney disease patients. Abdominal discomfort is commonly seen in CKD patients with no other causes of organic affection. Aim: to determine the prevalence of functional dyspepsia in CKD patients, and which subtype is predominant in them. Materials and patients: This observational study included 150 CKD patients. Clinical and laboratory data were recorded for every patient. All the patients were interviewed using the ROME IV questionnaire of functional dyspepsia. Patients fulfilling criteria for functional dyspepsia were exposed to upper GI endoscopy. Results: Overall, 73 (48.7%) of CKD patients were males and 77 (51.3%) were females with mean age of (45.71 ± 9.59) and mean BMI (26.58 ± 5.39). The frequency of functional dyspepsia among CKD patients was determined to be 14.7% (22 out of 150 patients). Among those affected by functional dyspepsia, the most prevalent subtype was found to be Epigastric Pain Syndrome (EPS), accounting for 59% (13 out of 22 cases). The most common predictor of FD in CKD patients was chronic HCV infection, hemodialysis, stage of CKD and eGFR as revealed by Univariate regression analysis. Conclusion: The prevalence of FD amongst CKD patients is 14.7% with EPS the predominant subtype. Male patients, HCV patients, patients with higher CKD stages and highly impaired eGFR (low eGFR) are more probable to have FD.
Runners participating in the 2008 Wachau half marathon (21,2 km) and the Vienna City marathon (42,5 km) as well as bicyclists participating at the Corinthian marathon (180km). Inclusion criteria:1) participation in at least one of these 3 marathons in the preceding two years,2)still in continuous training during the recruitment phase (at least 2 hours/week), 3) aged over 60. Exclusion criteria:(a) present or past exposure to neurotoxic substances (b) if they did not speak German as their native language (c) diseases that markedly affect CNS functions (d) manifest cardiovascular disease, (e) chronic alcoholism (daily alcohol intake \> 60 g or diagnosed history of alcoholism) and (f) unwillingness to give informed consent.
The population of the study will consist of the caregivers of hemiplegic patients receiving treatment in the clinic on the specified dates in Turgutlu State Hospital and Manisa Merkezefendi State Hospital Physical Therapy Service. The sample will consist of individuals who meet the inclusion criteria. Individuals in Turgutlu State Hospital will constitute the intervention group of the study and individuals in Manisa Merkezefendi State Hospital will constitute the control group of the study. The aim of this study was to determine the effect of progressive relaxation exercises applied to family members caring for hemiplegic patients on caregiving burden and meaning of life. In the intervention group, those who agree to participate in the study will be asked to fill in the Patient and Patient Relative Form, Cheltanhams Patient Classification Scale, Caregiving Burden Scale and Meaning and Purpose of Life Scale, which include personal information and information about the patient. Relaxation exercises will be explained and demonstrated by the researcher (Funda AKTÜRK) once a day for 1 month starting from the hospitalisation to the clinic and will be played on the computer. You will be asked to perform these exercises after listening to the video (CD). Relaxation exercises are exercises based on stretching and relaxing your muscles. Before the application, in the middle of the application (15th day) and at the end of the application, all forms except the introduction form will be filled in again. In the Control Group, those who agree to participate in the study will be asked to fill in the;Patient and Patient Relative Form, Cheltanhams Patient Classification Scale, Caregiving Burden Scale and Meaning and Purpose of Life Scale, which include personal information and information about the patient. The control group will be asked to fill in the forms at the same time as the intervention group without any intervention. If requested, progressive relaxation exercises will be applied to the control group after the end of the study