anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To investigate the potential phases in myopic retinal vascular alterations for further elucidating the mechanisms underlying the progression of high myopia (HM).
METHODS: For this retrospective study, participants diagnosed with high myopia at Beijing Tongren Hospital were recruited. Based on bionic mechanisms of human vision, an intelligent image processing model was developed and utilized to extract and quantify the morphological characteristics of retinal vasculatures in different regions measured by papilla-diameter (PD), including vascular caliber, arteriole-to-venule ratio (AVR), tortuosity, the angle of the vascular arch (AVA), the distance of the vascular arch (DVA), density, fractal dimension, and venular length. In addition, the optic disc and the area of peripapillary atrophy (PPA) were also quantified. The characteristics of the overall population, as well as patients aged less than 25 years old, were compared by different genders. Univariate and multiple linear regression analyses were conducted to investigate the correlation of retinal vasculature parameters with PPA width, and detailed trends of the vascular indicators were analyzed to explore the potential existence of staged morphological changes.
FINDINGS: The study included 14,066 fundus photographs of 5775 patients (aged 41.2 ± 18.6 years), of whom 7379 (61.2 %) were female. The study included 12,067 fundus photographs of 5320 patients (aged 41.2 ± 18.6 years). Significant variations in the morphological parameters of retinal vessels were observed between males and females. After adjusting for age and sex, multiple linear regression analysis showed that an increased PPA width ratio was associated with lower AVA (1PD), DVA (1PD), vascular caliber (0.5-1.0 PD), tortuosity (0.5-1.0 PD), density and fractal dimension (all P < 0.001, Spearman's ρ < 0). Overall, the changes in retinal vascular morphology showed two phases: tortuosity (0.5-1.0PD) and AVA (1PD) decreased rapidly in the first stage but significantly more slowly in the second stage, while vascular density and fractal dimension showed a completely opposite trend with an initial slow decline followed by a rapid decrease.
CONCLUSIONS: This study identified two distinct phases of retinal vascular morphological changes during the progression of HM. Traction lesions were predominant in the initial stage, while atrophic lesions were predominant in the later stage. These findings provide further insight into the development mechanism of HM from the perspective of retinal vasculature.
1402051 Lyophilised hair-dye products L'OREAL 25 June 1973 [26 June 1972] 29982/ 73 Heading DIB [Also in Division C4] A process for the preparation of lyophilisates of an indamine, indoaniline, indophenol or diamino-benzoquinone dyestuff, isolated from their reaction mixtures, comprises freezing a solution in one or more organic solvents or an aqueous organic solvent (by cooling), subliming the frozen product in vacuo by heating at a temperature below the melting point of the frozen product, and desorbing from the lyophilisate residual traces of liquids bonded to the lyophilised dyestuffs obtained after sublimation. Numerous compositions suitable for dyeing and for dyeing and wave setting hair are given, in conjunction with the lyophilisation process as applied to a large number of specific compounds. Two-component packs, or aerosol packs, may be used. A hair dye powder comprises a lyophilisate and at least one resin, optical brightening agent, thickener, surfaceactive agent, or an acid, basic or direct dyestuff. It may also be micro-encapsulated or in the form of coated particles. Wavesetting lotions may contain a lyophilisate composition, an alcohol and one or more film-forming cosmetic resins. Compositions may also contain at least one cosmetic resin, thickener, sun filter, perfume, optical brightening agent, antioxidant or other ingredient usually employed in hair dye compositions.
The present invention discloses an externally-used traditional Chinese medicine preparation for treating anal and intestinal disease and a preparation method thereof. The present invention belongs to the traditional Chinese medicine preparation and preparation method thereof. The medicine is mainly prepared from raw materials comprising 3 to 9 portions of heartleaf houttuynia herb, 1 to 4 portions of alum, 3 to 9 portions of sodium sulfate, 2 to 7 portions of zanthoxyli, 2 to 7 portions of ledebouriella root and 2 to 7 portions of angelica. The raw materials are prepared into a boiled solution or a powdered medicine to which heated water can be added for steaming and washing the affected regions by hip bath. The medicine is mainly used for treating various kinds of hemorrhoid, anus fissure, fistula in ano, sinusitis rectalis and eczema of anus, promoting postoperative wound healing, etc. Through clinical application of thousands of cases, the medicine is proved to have obvious treating effect and convenient use.
Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve as a potential mechanism linking pre-existing uncontrolled blood pressure (BP) to the occurrence of long-term COVID sequelae in patients undergoing hemodialysis (HD). This cross-sectional study examined serum IL-6 and IL-17 levels in 80 patients undergoing HD, considering preinfection BP, the presence of long-term COVID sequelae, and the time interval after acute COVID-19 infection, which was either 5 or 10 months. Controlled BP was defined as a 3-month average pre-dialysis BP < 140/90 mmHg and post-dialysis < 130/80 mmHg. The findings suggest that the prevalence of long-term COVID sequelae was significantly higher in patients with uncontrolled BP than in the BP-controlled group. Both IL-6 and IL-17 concentrations were also significantly higher in patients with uncontrolled BP compared with the BP-controlled group. The patients with long-term COVID sequelae had higher IL-6 and IL-17 values than the fully recovered patients at both time points, but their concentrations decreased significantly over time. Further research and prospective studies are warranted to validate these findings.
Childhood obesity is a global health concern affecting over 150 million children worldwide, with projections of a rise to 206 million by 2025. Understanding the mechanisms underlying this epidemic is crucial for developing effective interventions. In this study, we investigated circulating levels of Growth Differentiation Factor 10 (GDF10), a novel regulator of adipogenesis. Previous studies report diminished circulating GDF10 levels contribute to obesity and hepatic steatosis in mice. To further understand the role of plasma GDF10 in childhood obesity, a prospective case-control study was conducted. Using an enzyme-linked immunosorbent assay, plasma GDF10 levels were measured in children aged 5-17 years of age with normal (n = 36) and increased (n = 56) body mass index (BMI). Subsequently, plasma GDF10 levels were compared to various cardio-metabolic parameters. Children with increased BMI exhibit significantly lower levels of plasma GDF10 compared to children with normal BMI (p < 0.05). This study not only supports previous mouse data but is the first to report that lower levels of GDF10 is associated with childhood obesity, providing an important human connection for the relevance of GDF10 in obesity. Furthermore, this study revealed a significant correlation between low plasma GDF10 levels and elevated LDL-cholesterol and total cholesterol levels dependent on BMI (95% CI, p < 0.05). This study supports the hypothesis that children with obesity display lower plasma levels of GDF10, which correlates with elevated cholesterol levels. These insights shed light on potential mechanisms contributing to childhood obesity and may lead to future therapeutic interventions targeting GDF10 to mitigate adverse effects of adipogenesis in cardiometabolic health.
The invention provides a proved prescription used for treating heatstroke. Heatstroke is mainly caused by exposure to burning sun and working at a high temperature. The initial symptoms of heatstroke comprise dizziness, headache, palpitation, hypodynamia, thirst and nausea which disappear after rest for a short time. A patient with severe heatstroke has the symptoms of a body temperature as high as more than 40 DEG C, flushed face, scorching hot, dry and sweatless skin, muscle twitches, obnubilation, coma, etc. The proved prescription adopts Chinese herbal medicines as raw materials for treatment of heatstroke; a decoction is extracted from the raw materials by using a traditional herbal medicine decocting method and taken orally; the prescription realizes treatment of heatstroke based on nosogenesis and has no toxic and side effects. The prescription has a good treatment effect on dizziness, thirst, faint, coma, fever, fatigue, spontaneous perspiration, vexation, abdominal pain, diarrhea, chest distress and vomiting occurring due to heatstroke. The prescription is developed on the basis of years of repeated research and healing of hundreds of cases of patients with heatstroke; according to clinical observation of curative effects, a total effective rate of the prescription is 94%, and a cure rate of the prescription is 91%. The proved prescription for treating heatstroke is capable of relieving summer-heat, supporting healthy qi, cooling and refreshing a human body and radiating heat, can effectively activate immunologic functions of the human body and has the advantages of a good tranquilizing effect, a short treatment course, fast action and good consolidation performance.
PURPOSE:To improve the scalp to the state suitable for hair growth, and prevent the falling-off of the hair, itchiness of the skin and dandruff, by extracting the leaf, stalk and root of comfrey or its mixture with other vegetables by a proper extraction method, and applying the extracted liquid to the scalp. CONSTITUTION:The leaves, stalks or roots of comfrey, or its mixture with other vegetables, etc. are extracted e.g. with cold water or hot water to obtain the extracted liquid having a moderate concentration, and the liquid is applied to the scalp. It is preferable to use the agent for the prevention of the falling-off of the hair after the application of a hair-grower. The agent improves the blackness of the hair and gives aesthetic value to the hair.
Patients aged from 18 to 80 years old, suffering from ESRD, treated by chronic hemodialysis since at least 6 months and whose phosphatemia at the beginning of HD sessions ranged from 1.5 to 3 mmol/L. Phosphorus (31P) magnetic resonance spectroscopy will be performed in these patients during hemodialysis in order to measure intracellular phosphate and ATP concentrations and intracellular pH evolution during hemodialysis.
Patient education lasting 20-30 minutes was provided by the nurse who gives care in the surgical inpatient floor before the surgery. The nurse provided the patient's admission to the postoperative surgical inpatient floor and follow-up.
AIMS: The aim of the study is to assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6 and 12 months (M) follow-up.
METHODS AND RESULTS: A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 M. OCTPlus software uses artificial intelligence to assess composition (i.e. lipid, calcium, and fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention and 12 M were grouped into three terciles. Patients with larger MLA differences at 12 M (P = 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both P < 0.001, between the pre-DREAMS 3G OCT and the 6 and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 and 12 M follow-up, both P < 0.001.
CONCLUSION: The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 and 12 M. Following the implantation of DREAMS 3G, favourable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue.
Diquat (DQ) is a widely utilized nonselective herbicide that is primarily used to control a wide range of weeds and crop residues. It also has significant environmental implications. DQ exposure can cause severe damage to the central nervous system (CNS), a critical symptom of acute poisoning that endangers patients. Despite its severity, the underlying mechanisms of DQ-induced toxic encephalopathy remain unclear, hindering the development of precise treatments. Our research demonstrated that acute DQ exposure in mice significantly increases oxidative stress and triggers neuroinflammation in the hippocampus. Furthermore, in vitro findings indicate that the detrimental effects of DQ are mediated by its disruption of autophagic processes, leading to exacerbated neural damage. DQ initially promotes autophagy in BV2 microglia for self-protection against oxidative stress and inflammation. However, this process is subsequently blocked, intensifying neural damage. Crucially, our results show that the activation of autophagy can reverse these adverse effects. This study not only sheds light on the intricate mechanisms of DQ neurotoxicity but also provides potential therapeutic targets for mitigating DQ-induced toxic encephalopathy.
An antigen useful in the treatment of tuberculosis is prepared by subjecting an aqueous suspension of a dead Koch bacillus (Mycobacterium tuberculosis) and its products of metabolism to a precipitation reaction with an equivalent amount of an antibody solution, which is immune plasma, serum or blood (diluted or not with water) derived from an animal immunized with the dead Koch bacillus by inoculation with the latter in a dead or attenuated state and separating the upper liquid phase.  An antitubercular serum may be prepared by injecting the said upper liquid phase into an animal e.g. ox, sheep, pig or rabbit, and in due course extracting blood therefrom aseptically and preparing it for use as a serum.  In the example, 1 c.c. tuberculosous bacterial antigens are mixed with 1 c.c. old tuberculin diluted with water and allowed to stand three hours (Reagent 1).  This is injected into a bullock in small doses over 26 days, three months from the first injection allowed to lapse, and then blood is withdrawn aseptically.  After standing, the serum is separated, cresol is added, and after standing three weeks the serum is filtered through cotton, earth and porcelain filters (Reagent 2).  Six or seven drops of this serum are added to 1 c.c. of Reagent 1 and the mixture allowed to stand 24 hours at 37 DEG C.  The clear liquid is withdrawn, treated with another drop of serum (Reagent 2) and incubated 24 hours at 37 DEG C.  This is repeated until the addition of a drop of serum fails to produce a reaction after incubation. The so produced mixture is incubated at 37 DEG C. for a further 48 hours, and then at 55 DEG C. for 20 minutes.  The liquid produced when decanted from any residue is injected into an animal, which may be the same or different from that previously employed, and the antitubercular serum finally obtained from the blood of the animal is used medicinally for the treatment of tuberculosis in humans and animals.  The antigen prepared by the above process from M. Tuberculosis var. hominis is used to treat humans and that from M. tuberculosis var. bovine to treat animals.
Prevention of mother-to-child transmission (PMTCT) programs are effective if women take medication regularly, yet many perinatal women in sub-Saharan Africa have sup-optimal adherence. Intimate partner violence (IPV) worsens women's ability to adhere to antiretroviral therapy (ART), and leads to higher rates of depression. In a quasi-experimental feasibility study in South Africa, 2 inner-city Johannesburg clinics will be assigned to intervention or enhanced standard of care conditions. Intervention consists of training health workers to deliver one-on-one sessions in pregnancy (4 sessions) and postpartum (2 sessions) using problem-solving therapy and safety planning. Following n=80 women in a prospective cohort will allow for preliminarily assessment of intervention effects on: perinatal depression, IPV exposure, and ART adherence at 6 months postpartum. Additional qualitative research with 10 providers and 15 beneficiaries will help us qualitatively assess acceptability of intervention content, measures, and study conditions. This pilot trial can establish acceptability of intervention and control conditions and provide preliminary point estimates to inform future trial design.
For many men with metastatic prostate cancer, the cancer develops resistance to successive systemic therapies and eventually all treatment options are exhausted and the patient succumbs to their disease. It is therefore vital to find ways of evading prostate cancer resistance. Stereotactic body radiotherapy (SBRT) has the advantage that it destroys cancerous tissue irrespective of the underlying genetic deficit within the progressing metastasis. If the resistant clones are localized to 1-2 metastases and can be destroyed or ablated, the patient can continue to receive the benefit of their systemic (androgen deprivation) treatment (Abiraterone or Enzalutamide) which may continue to control the remainder of their disease for many months, possibly even years.

SBRT is a recognised technique for the elimination of isolated metastases in other tumour sites achieving local control of metastasis in 80-90% of cases. This is achieved with very few side effects. In the TRAP trial, the investigators wish to establish whether it is beneficial to target 1 or 2 metastatic sites with SBRT or whether patients will develop polymetastatic progression. Patients enrolled on the trial will receive 30 Gy in 5 fractions on alternate days over 10 days. They will continue their androgen deprivation treatment throughout and following SBRT. Side effects will be closely monitored throughout and patients will be seen at the end of radiotherapy and then 4 weeks after treatment. Thereafter patients will undergo trial follow up three monthly which will includes Prostate Specific Antigen (PSA) monitoring.

In addition to the above procedures, the investigators will use a combination of whole body (WB) diffusion weighted (DW) magnetic resonance imaging (WB DW MRI) and circulating tumour (ct) deoxyribonucleic acid (DNA), 'ct DNA' biomarker analysis with the aim of identifying those patients which benefit most from the combination of SBRT and androgen deprivation treatment. WB DW MRI is a novel MRI technique which shows improved sensitivity compared to standard MRI. The marker ctDNA enables the investigators to explore genomic characterisation and variation of metastases and compare findings with previously explored genome mutations in prostate cancer patients.
RATIONALE AND OBJECTIVES: This study aims to develop and validate a computed tomography (CT)-based radiomics nomogram for pre-operatively predicting central lymph node metastasis (CLNM) in patients with papillary thyroid microcarcinoma (PTMC) and explore the underlying biological basis by using RNA sequencing data.
METHODS: This study trained 452 PTMC patients across two hospitals from January 2012 to December 2020. The sets were randomly divided into the training (n = 339), internal test (n = 86), external test (n = 27) sets. Radiomics features were extracted from primary lesion's pre-operative CT images for each patient. After screening for features, five algorithms such as K-nearest neighbor, logistics regression, linear-support vector machine (SVM), Gaussian SVM, and polynomial SVM were used to establish the radiomics models. The performance of these five algorithms was evaluated and compared directly to radiologist's interpretation (CT-reported lymph node status). The radiomics signature score (Rad-score) was generated using a linear combination of the selected features. By combining the clinical risk factors and Rad score, a radiomics nomogram was established and compared with Rad-score and clinical model. The performance of the nomogram was evaluated based on the receiver operating characteristic (ROC) curve, calibration curve, and the decision curve analysis (DCA). The potential biological basis of nomogram was revealed by performing genetic analysis based on the RNA sequencing data.
RESULTS: A total of 25 radiomic features were ultimately selected to train the machine learning models, and the five machine learning models outperformed the radiologists' interpretation by achieving area under the ROC curves (AUCs) ranging from 0.606 to 0.730 in the internal test set. By incorporating the Rad score and clinical risk factors (sex, age, tumor-diameter, and CT-reported lymph node status), this nomogram achieved AUCs of 0.800 and 0.803 in the internal and external test set, which were higher than that of the Rad-score and clinical model, respectively. Calibration curves and DCA also showed that the nomogram had good performance. As for the biological basis exploration, in patients predicted by nomogram to be PTC patients with CLMN, 109 genes were dysregulated, and some of them were associated with pathways and biological processes such as tumor angiogenesis.
CONCLUSION: This radiomics nomogram successfully identified CLNM on pretreatment imaging across multiple institutions, exceeding the diagnostic ability of radiologists and had the potential to be integrated into clinical decision making as a non-invasive pre-operative tool.
This is a multicenter (study conducted at multiple sites), open label (all people know the identity of the intervention), randomized (the study medication is assigned by chance), parallel-group (each group of participants will be treated at the same time) study. Approximately, 60 participants will be enrolled in the study. This study will consist of a screening phase (maximum 14 days), an observation phase (92 days), and a follow-up phase (98 days). Participants will be randomly assigned to treatment group A, B, or C. During the observation phase, participants will receive injections of paliperidone palmitate of concentration ranging from 75 to 150 milligram equivalents in the deltoid muscle or gluteal muscle as applicable on Days 1, 8, 36, and 64 alternating between sides (left/right). Safety evaluations will include assessment of adverse events, clinical laboratory tests, electrocardiogram, vital signs, physical examination, injection site reaction, drug-induced extrapyramidal symptoms scale, and visual analog scale which will be evaluated throughout the study. The total study duration for each participant will be approximately 190 days.
An antibacterial toothpaste, comprising a charged antibacterial toothpaste abrasive. The charged antibacterial toothpaste abrasive comprises a ferroelectric ceramic. The ferroelectric ceramic is selected from at least one or a compound or a composition of more than one of potassium sodium niobate, i.e. K 0.5 Na 0.5 NbO 3 , barium titanate, i.e. BaTiO 3 , lithium niobate, i.e. LiNbO 3 , and barium strontium titanate, i.e. Ba x Sr 1-x TiO 3 , where 0 < x < 1. The charged antibacterial toothpaste abrasive can maintain good electrical stability, such that an antibacterial toothpaste containing same can play a lasting antibacterial role by utilizing a polarization effect, and has a relatively good antibacterial performance, thereby achieving both teeth cleaning and antibacterial effects.