anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Colorectal cancer is the third most common cancer in the U.S. and if detected early, has a favorable prognosis. Colorectal cancer survivors face many physical and psychosocial sequelae including second cancers, adverse effects on major organs, cognitive, and sexual function, problems in work and social roles and reduced quality of life. Following adjuvant treatments (chemotherapy and/or radiation), these individuals may be at increased risk for cardiovascular disease, obesity, osteoporosis and future cancers. There is growing evidence that moderate-intensity physical activity can improve physical functioning, reduce fatigue, enhance vigor and improve body esteem among those treated for breast cancer. Colorectal cancer survivors report increased fatigue, low vigor, impaired physical functioning and disturbances in body esteem. However, the group is relatively understudied and the potential benefits of increased physical activity to their recovery have not been examined. This study focuses on enhancing recovery by offering a home-based physical activity program to patients who have completed treatment for colorectal cancer. The program, based on our prior work among breast cancer survivors, consists of telephone-delivered physical activity counseling over three months. The counseling is based on the Transtheoretical Model, Social Cognitive Theory and elements of Motivational Interviewing. This study will test the efficacy of the physical activity intervention using a randomized controlled design among 134 patients who have completed treatment for colorectal cancer in the past 2 years. Outcomes will include physical activity behavior, fitness, vigor, fatigue, physical functioning, and body esteem among participants at baseline, 3 (posttreatment), 6 and 12 months. We will also track intervention costs and conduct exploratory analyses of moderators and mediators of change to help guide the future development of physical activity interventions to enhance recovery from colorectal cancer.
The invention discloses phosphoinositide compounds, as well as a preparation method and an application thereof. The phosphoinositide compounds are characterized by having the structure shown in formula (I). The invention also provides a preparation method and an application of the phosphoinositide compounds. The phosphoinositide compounds provided by the invention are good in cellular permeability, high in phosphatidase stability, and high in activity in inhibiting the growth of the tumor cells. The preparation method of the phosphoinositide compounds provided by the invention is a click c-Hemi-s-try method, and is simple and efficient. The phosphoinositide compounds and the preparation method of the phosphoinositide compounds provided by the invention are widely applied to the field of anti-tumor medicines.
PROBLEM TO BE SOLVED: To obtain an anticariogenic composition capable of suppressing production of glucan due to bacterium causing dental caries by including α- mannooligosaccharide. SOLUTION: This anticariogenic composition comprises an αmannooligosaccharide. The α-mannooligosaccharide consists mainly of an oligosaccharide obtained by bonding 2-10 mannoses at α-position and the bonding includes α-1,1, α-1,2, α-1,3, α-1,4 or α-1,6 bond. Such α-mannooligosaccharide is obtained by a method decomposing mannan of cell wall, etc., of microorganism with oxygen or an acid, a method, etc., carrying out condensation reaction of α-mannosidase from mannose. Further, commercially available α- mannooligosaccharide can also be used as the α-mannooligosaccharide. A composition for oral cavity or beverage and food are exemplified as the anticariogenic composition and preferable concentration of the α-mannooligosaccharide in these compositions is 0.01-5 wt.%.  It is desirable to ingest the beverage or food in an amount of >=1 g, preferably >=5 g/day when the beverage or food is ingested in order to prevent caries.
During the first four weeks, the subjects were monitored primarily concerning bowel discharges and general health. After that initial four weeks, they are re-evaluated compliance with inclusion and exclusion criteria. Participants were allocated to the double-blind section of the trial (12 weeks), using o computer-generated to a placebo group or in the probiotic group in the form of a liquid oral formulation once a day. On first day of intervention participants provide a blood sample. All investigators, participants and study personnel were blinded to the order of randomization. Participants were told to consume 9 drops of study probiotics once a day for next 12-week intervention. On last day of intervention, participants provide a blood sample. The last four weeks of the double-blind section (week 9-12) participants an evaluation period in which the respondents were evaluated for the outcomes of the study. After completing the double-blind study, the participants were followed for an additional four weeks. Inclusive / Excluded criteria are evaluated on two occasions, at the time of inclusion in the 4-week introductory section and its end.
Secondary bacterial infections such as pneumococcal pneumonia are a leading cause of death during influenza endemics. Individuals recently infected with influenza become more susceptible to pneumonia, an effect associated with increased density of pneumococcal carriage in the nose and uncontrolled inflammatory immunological responses. The interaction of influenza virus and pneumococcus has been known and well documented. Recent works have shown that the Live Attenuated Influenza Vaccine (LAIV) enhances pneumococcal carriage in murine models. These results highlighted the potential effect of mass immunization of children with LAIV on pneumococcal carriage. Increased carriage could lead to increased pneumococcal disease in LAIV-vaccinated individuals as well as increased bacterial transmission within the population. LAIV has been licensed for use in children since 2011 in Europe, and has been increasingly administered in children and adults in the USA. There is an urgent need for a clinical trial that will determine the effect of LAIV on pneumococcal carriage dynamics.

The investigators have developed a safe and reproducible experimental human pneumococcal carriage (EHPC) model. The investigators will use EHPC to define the effect of antecedent and concurrent LAIV on pneumococcal carriage acquisition, density and duration. The investigators will perform two double - blinded Randomised Controlled Trials (RCT) to compare LAIV with Quadrivalent Inactivated Influenza Vaccine (QIV). The investigators will compare clinical symptoms, pneumococcal carriage density and duration associated with both vaccines administered antecedent to or concurrently with EHPC inoculation. Changes in the nasopharyngeal microbiome, inflammatory responses in the nasal mucosal and lung cellular immunity associated with influenza virus and pneumococcus interaction will be investigated. This project may provide some reassurance regarding the impact of mass immunization with LAIV on carriage or, if carriage is increased, will provide knowledge of how a natural carriage episode might develop into pneumonia in susceptible subjects during pandemic influenza.
The emergent fungal pathogen Candida auris is increasingly recognised as an important cause of healthcare-associated infections globally. It is highly transmissible, adaptable, and persistent, resulting in an organism with significant outbreak potential that risks devastating consequences. Progress in the ability to identify C. auris in clinical specimens is encouraging, but laboratory diagnostic capacity and surveillance systems are lacking in many countries. Intrinsic resistance to commonly used antifungals, combined with the ability to rapidly acquire resistance to therapy, substantially restricts treatment options and novel agents are desperately needed. Despite this, outbreaks can be interrupted, and mortality avoided or minimised, through the application of rigorous infection prevention and control measures with an increasing evidence base. This review provides an update on epidemiology, the impact of the COVID-19 pandemic, risk factors, identification and typing, resistance profiles, treatment, detection of colonisation, and infection prevention and control measures for C. auris. This review has informed a planned 2024 update to the United Kingdom Health Security Agency (UKHSA) guidance on the laboratory investigation, management, and infection prevention and control of Candida auris. A multidisciplinary response is needed to control C. auris transmission in a healthcare setting and should emphasise outbreak preparedness and response, rapid contact tracing and isolation or cohorting of patients and staff, strict hand hygiene and other infection prevention and control measures, dedicated or single-use equipment, appropriate disinfection, and effective communication concerning patient transfers and discharge.
The present invention provides traditional Chinese medicine elixation for curing senile acute uroschesis diseases. The present invention is characterized in that the traditional Chinese medicine elixation for curing senile acute uroschesis diseases is prepared from the raw materials of the following dosage proportioning: 3 to 20g of rhubarb, 9 to 50g of talc, 9 to 30g of pink herb, 3 to 20g of armand clematis, 9 to 30g of common knotgrass herb, 3 to 20g of scutellaria, 3 to 15g of stir-baked fructus gardeniae, 5 to 30g of plantain seed and 3 to 30g of liquorice. According to China medicine principles that excess syndromes are cured with a purgative method and unblocked transmission is used as a normal functional state of the internal organs, patients with usual bladder damp heat, lung heat, blockage and acute uroschesis are cured by medicine with the functions of heat fire clearing, dampness removal and blockage removal. The rhubarb is used for removing stagnated heat, so urinary bladder qi automatically evacuate; the talc is used for clearing the six bowels, so the blockage of the water tracts automatically eliminate; the pink herb is used for clearing heat and alleviating edema; the armand clematis is used for reducing fire and promoting urination; the common knotgrass herb is used for draining urinary bladder ponding; the scutellaria is used for clearing lung heat and upper jiao heat; the stir-baked fructus gardeniae is used for clearing sanjiao stagnated heat; the plantain seed is used for clearing heat so as to unclog blocked seminal orifice; the liquorice is used for purging the pathogenic fire so as to activating the bodies. The combination of the medicine can achieve the effects of heat fire clearing, urination promotion and blockage unclogging so as to eliminate heat, clear the urinary bladder, make urination uninhibit and eliminate uroschesis. The traditional Chinese medicine elixation for curing senile acute uroschesis diseases of the present invention.
This study is affiliated to Sino Longitudinal Study on Cognitive Decline, SILCODE. Alzheimer's disease (AD) is the most common cause of dementia, which severely injures multiple domains of cognitive functions in the aging people, bringing heavy burden to the society and families. Studying the cognitive brain damage mechanism of subjective cognitive decline (SCD), the preclinical stage of AD, would provide great opportunities for understanding the pathogenesis of AD and clinical value for early diagnosis and intervention in AD. The project intends to utilize amyloid-PET and FDG-PET for screening and then employ the comprehensive neuropsychological examination combined with multi-modal MRI neuroimaging techniques to study the brain functions and structures of the normal aging and SCD. The imaging data would be analyzed from several levels, including the cognitive dimensions, brain activation patterns, and especially functional and structural networks to establish the models of normal and pathological cognitive aging, which mainly be modulated by frontal-parietal control system. We aim to establish models of normal and pathological cognitive aging. Furthermore, the longitudinal data of SCD population would be collected to study the dynamic changes of brain networks so as to explore the progressive mechanisms of AD on brain networks and to construct a high-precision multi-modal model for early diagnosis
The standard-of-care group receives short-course radiation therapy (5 × 5 Gy) followed by six cycles of CAPOXIRI (capecitabine 800 mg/m2 orally twice daily on days 1-14, oxaliplatin 130 mg/m2 intravenously on day 1, and irinotecan 150 mg/m2 intravenously on day 1\*, q3wks). If the initial dose of irinotecan 150 mg/m2/day is tolerated, the dose can be increased to 200 mg/m2/day from the second cycle.
OBJECTIVE: To analyse the risk factors for post-operative recurrence or progression of intravenous leiomyomatosis and explore the impact of different treatment strategies on patient prognosis.
METHODS: Patients with intravenous leiomyomatosis who underwent surgery from January 2011 to December 2020 and who were followed for ≥3 months were included. The primary endpoint was recurrence (for patients with complete resection) or progression (for patients with incomplete resection). Kaplan-Meier survival analysis was used to analyse the factors affecting recurrence.
RESULTS: A total of 114 patients were included. The median age was 45 years old (range 24-58). The tumors were confined to the uterus and para-uterine vessels in 48 cases (42.1%), while in 66 cases (57.9%) it involved large vessels (iliac vein or genital vein and/or proximal large veins). The median follow-up time was 24 months (range 3-132). Twenty-nine patients (25.4%) had recurrence or progression. The median recurrence or progression time was 16 months (range 3-60). Incomplete tumor resection (p=0.019), involvement of the iliac vein or genital vein (p=0.042), involvement of the inferior vena cava (p=0.025), and size of the pelvic tumor ≥15 cm (p=0.034) were risk factors for recurrence and progression. For intravenous leiomyomatosis confined to the uterus or para-uterine vessels, no post-operative recurrence after hysterectomy and bilateral oophorectomy occurred in this cohort. Compared with hysterectomy and bilateral oophorectomy, the risk of recurrence after tumorectomy (with the uterus and ovaries retained) was significantly greater (p=0.009), while the risk of recurrence after hysterectomy was not significantly increased (p=0.058). For intravenous leiomyomatosis involving the iliac vein/genital vein and the proximal veins, post-operative aromatase inhibitor treatment (p=0.89) and two-stage surgery (p=0.86) were not related to recurrence in patients with complete tumor resection.
CONCLUSION: Incomplete tumor resection, extent of tumor lesions and size of the pelvic tumor were risk factors for post-operative recurrence and progression of intravenous leiomyomatosis.
OBJECTIVE: This study aimed to assess the neuroimaging abnormalities and their progression in patients with Subacute sclerosing panencephalitis (SSPE) and identify clinical predictors of these imaging findings.
METHODS: This prospective observational study evaluated clinical and neuroimaging features in patients with SSPE. Patients were categorized using Dyken's criteria, Jabbour's staging system, and the definition of fulminant SSPE. They underwent comprehensive clinical assessments, cerebrospinal fluid examination, Electroencephalogram (EEG), and Magnetic Resonance Imaging (MRI) scans. Treatment involved intrathecal interferon‑α and antiepileptic medications. Functional disability was assessed using the modified Barthel index. Follow-ups were performed at 6 months, including reassessment of Modified Barthel Index (MBI) and Jabbour's staging and EEG and MRI scans.
RESULTS: The mean age was 13.9 ± 6.7 years, with males comprising 81.5% (44/54) of the cohort. Fulminant SSPE was noted in 33% (18/54) of cases. Disease duration before presentation varied significantly between fulminant and non-fulminant forms (p = 0.001). Neuroimaging abnormalities were more prevalent in JS III stage patients, with diffuse cerebral atrophy being a significant finding (p = 0.011). Basal ganglia involvement correlated with movement disorders. The 6‑month follow-up showed increased cerebral atrophy (p = 0.004). Increasing disease duration was an independent predictor of cerebral atrophy. An Intercomplex interval (ICI) of more than 10 minutes correlated with normal neuroimaging, 10 patients died within the study period, 8 of whom had fulminant SSPE.
CONCLUSION: Parieto-occipital White matter hyperintensity (WMH) is the most prevalent and sensitive neuroimaging finding for the diagnosis of SSPE. Despite interferon treatment, cerebral atrophy progressed in both aggressive and fulminant SSPE. Increasing disease duration is an independent predictor of cerebral atrophy.
SINGULAIR 4-mg oral granules can be administered either directly in the mouth, dissolved in 1 teaspoonful (5 mL) of cold or room temperature baby formula or breast milk, or mixed with a spoonful of cold or room temperature soft foods; based on stability studies, only applesauce, carrots, rice, or ice cream should be used. The packet should not be opened until ready to use. After opening the packet, the full dose (with or without mixing with baby formula, breast milk, or food) must be administered within 15 minutes. If mixed with baby formula, breast milk, or food, SINGULAIR oral granules must not be stored for future use. Discard any unused portion. SINGULAIR oral granules are not intended to be dissolved in any liquid other than baby formula or breast milk for administration. However, liquids may be taken subsequent to administration. SINGULAIR oral granules can be administered without regard to the time of meals.
During the last 25 years evidence that newborns can experience pain has been increasing. Painful procedures (injections, heel lances, and circumcisions) are part of normal routine newborn care. Studies have demonstrated that newborns have increased sensitivity to pain when compared with older children and adults. Pain assessment and management is an important component in the overall care of the newborn infant and safe, effective analgesics are needed.

Pain assessment is complicated by the infants' verbal and cognitive limitations. Heart rate, blood pressure and oxygen saturation are commonly monitored in the nursery in response to pain, yet these parameters are affected by handling, illness, medications, as well as by pain. Skin blood flow has been documented to increase in premature newborns undergoing painful procedures in the Newborn Intensive Care Nursery. In the present study, Laser Doppler Imager technology will be used to define changes in skin blood flow response to heel lance and oral sucrose administration in normal newborn infants.
Immediately after epidural placement, patient will be placed in a left tilt position with her hip on a wedge and both of her legs elevated on an orange peanut ball. She will remain in this position for approximately 40 minutes.
The present invention is directed to a method and system for managing patient care in order to minimize caregiver error. The system may be driven by machine readable identifiers. The identifiers may include bar codes. The system is also task-based so as to minimize caregiver input and the possibility of caregiver error. The system includes a caregiver portable information device having a scanning device. The system additionally includes a patient machine readable identifier and a medication machine readable identifier. The system further includes a dynamically generated patient task list for an identified patient, the task list including instructions for administration of at least one medication, wherein the task list becomes available upon scanning of the patient machine readable identifier by the scanning device.
PURPOSE:To obtain the titled remedy having controlling action on release of drug, readily bondable to mucosa in application to the vagina, capable of feeding a drug to the affected part for a long time, by dispersing specific particles into a water-soluble high polymer to give a base and dispersing an active substance into the base. CONSTITUTION:One or more substances effective for treating candidiasis are dispersed into a base for preparation. In the operation, a material obtained by dispersing granules comprising a water-insoluble high polymer, a high polymer decomposable in organisms or a high polymer soluble in a limited pH range into a water-soluble high polymer (e.g. methyl cellulose) is used as the base. The remedy is readily bonded to mucosa of vaginal mucosa, slightly releasable because of high adhesion and can freely control release of a treating active component. Use of the drug can maintain medicinal effects for a long period and show immediate effects.
Subjects will administer oral solution with doses 0.5 mg up to 4.5 mg and capsule for doses 5 mg and upwards of GSK3439171A and placebo as per randomized sequence: Dose 7 of GSK3439171A followed by PBO followed by Dose 9 of GSK3439171A in P3. There will be a washout period of 7 days or 5 half-lives, whichever is longer in between the doses.
Focusing on a specific conversation amidst multiple interfering talkers is challenging, especially for those with hearing loss. Brain-controlled assistive hearing devices aim to alleviate this problem by enhancing the attended speech based on the listener's neural signals using auditory attention decoding (AAD). Departing from conventional AAD studies that relied on oversimplified scenarios with stationary talkers, a realistic AAD task that involves multiple talkers taking turns as they continuously move in space in background noise is presented. Invasive electroencephalography (iEEG) data are collected from three neurosurgical patients as they focused on one of the two moving conversations. An enhanced brain-controlled assistive hearing system that combines AAD and a binaural speaker-independent speech separation model is presented. The separation model unmixes talkers while preserving their spatial location and provides talker trajectories to the neural decoder to improve AAD accuracy. Subjective and objective evaluations show that the proposed system enhances speech intelligibility and facilitates conversation tracking while maintaining spatial cues and voice quality in challenging acoustic environments. This research demonstrates the potential of this approach in real-world scenarios and marks a significant step toward developing assistive hearing technologies that adapt to the intricate dynamics of everyday auditory experiences.
Intra-articular injections in the hip of saline, solution week 1 and 2 post-operatively. Dose: 5 mL at each injection.
Participants will receive one tablet of the marketed reference containing Levodopa and Carbidopa 250 mg/ 25 mg. The tablet will be taken with water and in a fasting condition.
Shi-style manipulations is a cervical manipulation for cervical spondylosis.This manipulation is a kind of traditional Chinese massage and it can dredge the meridians. Patients are treated every day for 30 minutes. Seven times as one course and totally there are two courses. 3 times a week, once the other day（except the weekends）,30 minutes, 2 weeks.
PROBLEM TO BE SOLVED: To provide a method of washing, application and antibacterial treatment solution using an enzyme treatment solution which can maintain antibacterial action for a long time by effectively separating and removing dirt (residue) forming on the surface of the subject of treatment such as a food manufacturing facility or a cooking facility.SOLUTION: An enzyme treatment solution formed by adding and mixing in 100 pts.wt. of cold or hot water (80°C or less) an enzyme treatment agent comprising 0.2-1.2 pts.wt. of papain and 0.1-1.4 pts.wt. of pancreatin as enzymes and 0.2-2.4 pts.wt. of adenosine triphosphate disodium salt, 0.2-1.2 pts.wt. of a Bacillus protease, and 0.2-1.0 pt.wt. of L-glutamic acid as auxiliary agents is used for the washing of or application to the subject of treatment for an antibacterial treatment.