anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nearly half of the world's population experiences labor and delivery processes which are associated with microscopic or gross tissue injury to the mother. Since this experience is widespread and occurs relatively early in life, the psychosocial, medical, and financial consequences of chronic pain following childbirth could be enormous. Surprisingly, previous studies with long term follow up of new mothers have included pain as a secondary measure and / or have focused on prevalence of pain without determining whether pain predated delivery or even pregnancy itself. The investigators recently performed a long term follow up study of over 1,200 women, and noted that pain which began during the childbirth itself was surprisingly rare in comparison to other physical injuries. Additionally, two central factors hypothesized to confer risk of chronic pain after other injuries including surgery, pre-dating chronic pain and degree of tissue and nerve injury, contributed minimally to the acute and sub-acute pain after childbirth. These two observations, low incidence of chronic pain and minimal effect of degree of tissue injury and history of chronic pain on sub-acute pain, point towards a potential protective effect of pregnancy or delivery on the response to physical injury.
RT group (RG, n = 21), YJJ group (YG, n = 22), BDJ group (BG, n = 21). These groups performed the assigned exercises for 24 weeks (3 times/week, 60 min/time).
Serious and rarely fatal hypersensitive reactions have been reported in patients receiving therapy with tramadol. When these events do occur, it is often following the first dose. Other reported hypersensitivity reactions include pruritus, hives, bronchospasm, angioedema, toxic epidermal necrolysis and Stevens-Johnson syndrome. Patients with a history of hypersensitivity reactions to tramadol and other opioids may be at increased risk and therefore should not receive CONZIP. If anaphylaxis or other hypersensitivity occurs, stop administration of CONZIP immediately, discontinue CONZIP permanently, and do not rechallenge with any formulation of tramadol. Advise patients to seek immediate medical attention if they experience any symptoms of a hypersensitivity reaction [see Contraindications (4)].
BACKGROUND: Despite concerns about worsening pregnancy outcomes resulting from healthcare restrictions, economic difficulties and increased stress during the COVID-19 pandemic, preterm birth (PTB) rates declined in some countries in 2020, while stillbirth rates appeared stable. Like other shocks, the pandemic may have exacerbated existing socioeconomic disparities in pregnancy, but this remains to be established. Our objective was to investigate changes in PTB and stillbirth by socioeconomic status (SES) in European countries.
METHODS: The Euro-Peristat network implemented this study within the Population Health Information Research Infrastructure (PHIRI) project. A common data model was developed to collect aggregated tables from routine birth data for 2015-2020. SES was based on mother's educational level or area-level deprivation/maternal occupation if education was unavailable and harmonized into low, medium and high SES. Country-specific relative risks (RRs) of PTB and stillbirth for March to December 2020, adjusted for linear trends from 2015 to 2019, by SES group were pooled using random effects meta-analysis.
RESULTS: Twenty-one countries provided data on perinatal outcomes by SES. PTB declined by an average 4% in 2020 {pooled RR: 0.96 [95% confidence intervals (CIs): 0.94-0.97]} with similar estimates across all SES groups. Stillbirths rose by 5% [RR: 1.05 (95% CI: 0.99-1.10)], with increases of between 3 and 6% across the three SES groups, with overlapping confidence limits.
CONCLUSIONS: PTB decreases were similar regardless of SES group, while stillbirth rates rose without marked differences between groups.
PURPOSE:To provide an collagenase activity inhibitor capable of expecting effects for preventing and treating periodontal disease and having high safety by containing a collagenase activity inhibitor containing caffeic acid or its salt or ascorbic acid or its salt. CONSTITUTION:(A) Caffeic acid or its salt, e.g. caffeic acid sodium salt is blended as an essential ingredient and as necessary, (B) ascorbic acid, erythorbic acid or its salt is combinedly used to provide the objective collagenase activity inhibitor, especially suitable for composition for oral cavity such as gum, mouth cleaning agent or dentifrice. The inhibitor has excellent inhibiting activity to collagenase which is cause of collagen absorption of gingiva and alveolar bone in periodontal disease and is useful for prevention and treatment of periodontal disease and extremely high also in safety on use regardless of content of blend amount. Furthermore, although sufficient effects are exhibited also by the ingredient A alone, synergistic effects are exhibited by combination with the ingredient B. The ingredients A and B are preferably each blended at amounts of 0.001-5, especially 0.01-3.0wt.% and 0.001-5, especially 0.002-3.0wt.%, based on 100wt.% total amount of applied composition.
Participants in this group will have been treated with alendronate for at least 1 year prior to study entry. Upon study entry, they will continue taking alendronate alone. Biopsies will be performed at Week 7 and then participants in this group will be offered teriparatide as part of Group 2 or 3.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to endocrinology, and deals with treatment of patients with neuropathic and neuroischemic forms of "diabetic foot" syndrome. For this purpose at the first stage on both extremities injection of 0.25% Novocain is made in dose 50.0 ml into fascial compartment of common paroneal nerve in distal direction to upper musculo-peroneal canal. After 1-2 days as the second stage injections of 0.125% Novocain solution in amount 50.0 ml are repeated in turns into each extremity with interval 3-5 days, course containing 5-6 injections. ^ EFFECT: elaborated doses and mode of Novocain introduction provide possibility to preserve foot due to stopping purulent inflammation with absence of side effects. ^ 1 ex
Identical surgical treatment plus Smith \& Nephew bio-inductive patch implant. Ultrasounds preoperatively and 6 months postoperatively.
PURPOSE: A composition containing tannin for relieving and preventing snoring is provided to ensure simple portability and to prevent sleep apnea syndrome. CONSTITUTION: A composition for relieving and preventing snoring comprises 0.1-10 weight% of tannin based on total composition weight. The composition also contains 0.1-10 weight% of alum. The composition also contains Schizandrae Fructus, platycodon grandiflorum, Liriopis Tuber or Cnidii Rhizoma. The dose of the tannin or alum is 1~1000mg/day. The composition is manufactured in a tablet form.
BACKGROUND: There have been various clinical studies on the effect of dietary inflammatory index (DII) on circulating inflammatory biomarkers, but the findings from these are contradictory. The aim of the present study was to clarify any association.
METHODS: The PubMed, Embase, Web of Science and Cochrane Library database were searched for relevant studies from inception February 2021. There were no language restrictions. Two investigators independently selected eligible studies. Measures of association were pooled by using an inverse-variance weighted random-effects model. The heterogeneity among studies was examined using the I2 index. Publication bias, sensitivity and subgroup analyses were also performed.
RESULTS: A total of 13 cross-sectional studies were identified, involving 54,813 participants. The adjusted pooled OR of C-reactive protein (CRP) levels for the highest (the most pro-inflammatory diet) versus lowest (the most anti-inflammatory diet) DII categories was 1.25 (95% CI: 1.18-1.32; I2  = 59.4%, P = .002). Subgroup analyses suggested the main source of study heterogeneity was the geographic area (Asia, Europe, or USA) and CRP levels (>3 mg/L or others). This finding was remarkably robust in the sensitivity analysis.
CONCLUSION: The meta-analysis suggests that more pro-inflammatory DII scores were positively associated with CRP, the DII scores can be useful to assess the diet inflammatory properties and its association with low-grade inflammation.
All of the families constituting the sample of the study (30 mobile application-study group) will be told about burn prevention and first aid practices with a training (powerpoint presentation) prepared by the executive researcher in line with the literature and their questions will be answered. Then, the training to be given with the mobile application will be downloaded to the phones of the families in the experimental group and the training will continue through the application.
The present invention relates to an extract of combined vegetable medicine for curing coronary heart diseases and a method of extraction. Raw materials contain red sage root, red ginseng, dwarf lilyturf root and schisandra. After the schisandra and the red sage root are extracted by water, alcohol is used for extraction. The red ginseng and the dwarf lilyturf root are extracted by the alcohol and are extracted by normal butyl alcohol. Distillation is matched, and macroporous resin is used for sorption extraction. Extracts are combined to obtain the extract of combined vegetable medicine. An oral preparation is prepared from the extract and contains tablets, capsules, soft capsules, drop pills, granules and oral liquid. After the extract is processed by active carbons and pH values, an injection is prepared. The present invention is extracted by a strict modernization method. By medicine, virus theories, clinical tests and modern methods, effective contents and heavy metals are detected. Compared with traditional prescriptions, the present invention is the new medicine of traditional Chinese medicine with the advantages of stable and controllable quality, high safety, good effects, high efficiency, quick effects and few toxic side effects. By experimental verification, the extract of the combined vegetable medicine of the present invention and a preparation prepared by different extraction methods have exact curative effects on curing coronary heart diseases, myocardial ischemia, etc.
PURPOSE:A hair treatment, e.g. permanent waving agent, semipermanent setting agent or fixing agent for hairdressing, containing deoxyribonucleic acid or a salt thereof, and having improved waving effect and wave retaining effect. CONSTITUTION:A hair treatment, containing deoxyribonucleic acid or a salt thereof, e.g. Na or K salt, in an amount of 0.01-5.0wt%. The deoxyribonucleic acid or the salt thereof has cationic, anionic and nonionic sites in the molecule thereof and the property of bonding to the ionic sites of keratinous protein in the skin and adsorbing easily on the skin surface by the mutual action, and is capable of combing the hair by giving lubricity thereto and imparting a comfortable feeling. A sufficient effect is obtained even if the amount of an alkali agent, e.g. aqueous ammonia, is small, and therefore an uncomfortable odor is not smelt.
Cobalamin-peptide complexes are prepared by mixing a cobalamin with a peptide from corn steep liquor.  The process may be effected by using heat sterilised and filtered corn steep liquor, preferably the latter has been maintained at an acid pH e.g. below about 3.  Most preferably (a) the peptide is obtained from the said liquor by extraction therefrom into an organic solvent and re-extraction into water, and (b) the corn steep liquor or peptide is treated with cyanide ions prior to mixing into cobalamin.  The cobalamin-peptide complexes may be precipitated from aqueous solutions containing, e.g. (i) at least 1000 and preferably about 5000 micro g/ml of cobalamin when using acetone as precipitating agent, or (ii) about 500 micro g/ml when using ammonium sulphate as said agent.  It is preferred to use such a quantity of cobalamin that the solutions have an optical density ratio of 0.7-1.3 at 278 and 361 mm ; such solutions are stated to have generally a cobalamin/peptide ratio of 1:3-9.  In the examples glucose and phenol are optional additives to the corn steep liquor prior to extraction with phenol/benzene, to which butyl acetate may be added before the aqueous extraction step, and the aqueous layer may be washed with butanol.  In example 3, solid cobalamin/peptide complex was isolated by freeze-drying of a solution having a cobalamin/peptide ratio of 1:9.8 and an optical density ratio of 1:1.25 at 278 and 361 mm .  The complexes may be made up into pharmaceutical preparations using solid or liquid diluents.
A system and a method allowing a technician to monitor the condition of a plurality of patients and communicate their condition to an attending clinician. A centralized receiving station receives signals from each of the patients being monitored. A graphical user interface 10 simultaneously displays an indication of patient condition for each of a plurality of patients. The technician monitors the physiological condition of the patients, reviewing any alarm signals that are sent for verification before notifying the clinician via a communications transmission. When the clinician responds to the transmission with his own response transmission, the response is indicated on the monitoring display 10. If the clinician does not send a response transmission the technician will move to an escalated communications transmission until the clinician sends a response transmission back to the central monitoring station. The single informative display simplifies the cognitive load on the technician; does not rely on the technician's memory; allows for greater continuity of health care support between changes of technician: and allows for greater prioritising of patient alarms ensuring that a low priority but currently unattended alarm will not take priority over a more critical alarm.
A health outcomes and disease management network and related method is provided for efficiently and effectively monitoring patient status as well as providing recommendations for improved patient healthcare. The system and method employs, among other things, a plurality of remote monitoring stations and a computer network. Each of the remote monitoring stations includes at least one measuring device, adapted to measure a physiological condition of a respective patient, and to provide data representative of the physiological condition for inclusion among patient health-related data pertaining to a respective patient. The health-related data can include, for example, data relating to a patient's heart. The computer network comprises a database containing accumulated health-related data pertaining to health-related conditions and treatment. The computer network is adapted to receive the patient health-related data from the remote monitoring stations via, for example, the Internet. Healthcare managers, each assigned to groups of patients, along with primary care providers, coordinate with each other to establish treatments programs for the patients based on their respective patient health-related data and the accumulated health-related data, and to revise the accumulated health-related data based on the patient health-related data. The computer network is further adapted to provide the accumulated health-related data stored in the database to organizations financing at least a portion of the treatment programs, and is adapted to receive financial data pertaining to the treatment programs from the organizations and to store the financial data in the database.
AIMS: Elucidating the impacts of long-term spaceflight on cardiovascular health is urgently needed in face of the rapid development of human space exploration. Recent reports including the NASA Twins Study on vascular deconditioning and aging of astronauts in spaceflight are controversial. The aims of this study were to elucidate whether long-term microgravity promotes vascular aging and the underlying mechanisms.
METHODS AND RESULTS: Hindlimb unloading (HU) by tail suspension was used to simulate microgravity in rats and mice. The dynamic changes of carotid stiffness in rats during 8 weeks of HU were determined. Simulated microgravity led to carotid artery aging-like changes as evidenced by increased stiffness, thickness, fibrosis, and elevated senescence biomarkers in the HU rats. Specific deletion of the mechanotransducer Piezo1 in vascular smooth muscles significantly blunted these aging-like changes in mice. Mechanistically, mechanical stretch-induced activation of Piezo1 elevated microRNA-582-5p in vascular smooth muscle cells, with resultant enhanced synthetic cell phenotype and increased collagen deposition via PTEN/PI3K/Akt signalling. Importantly, inhibition of miRNA-582-5p alleviated carotid fibrosis and stiffness not only in HU rats but also in aged rats.
CONCLUSIONS: Long-term simulated microgravity induces carotid aging-like changes via the mechanotransducer Piezo1-initiated and miRNA-mediated mechanism.
A starting point for this 'Ecological-Exercise-Intervention'(EEI), would be to limit sitting time to no more than 2 hours/day, and to stand up and move after 30 minutes of continuous sitting. In accordance with several epidemiologic evidences light-intensity activities would be encouraged to substitute sedentary time (e.g., standing up while talking on the telephone, ironing while watching TV). Taking into consideration the guidance provided by ecologic models of health behavior evidences about specific constructs to guide EEI may be derived from behavioral research on physical activity.
FIELD: agriculture, pharmaceutical industry. SUBSTANCE: method includes multiple boiling of velvet antlers in hot water, ventilation and oven dryings. Moreover, before the first oven drying the section of velvet antlers is covered with yeast dough by rubbing it in, oven dryings are carried out at 65-70 C. Velvet antlers should be put horizontally at lateral inclination during oven dryings. The method provides to obtain and keep biologically active substances, improve trade qualities and prevent internal structure of velvet antlers against the damage caused by flies' larvae. EFFECT: higher efficiency. 1 cl, 2 tbl
Compositions including a polypeptide or nucleic acid sequence encoding a polypeptide that binds TAR DNA (particularly the region -18 to +28 of HIV-LTR DNA) and that does not bind to TAR RNA (particularly the region +1 to +80 of the TAR RNA) are disclosed. The cellular binding protein TDP-43 including the polypeptide has an estimated molecular weight of between about 40 kD and 46 kD as determined by SDS polyacrylamide gel electrophoresis. Fusion proteins that include the entire cellular binding protein TDP-43 or fragments thereof are also described. The cellular binding protein, peptide fragments and nucleic acid sequences encoding them, repress HIV gene expression. Methods for preparing the cellular binding protein from cells as recombinant proteins with recombinant host cells are also disclosed. Antibodies to the TDP-43 cellular binding protein are also described. The isolated nucleic acid sequences of the protein and its fragments are described in the construction of retroviral vectors. Methods for using the cellular binding protein, polypeptides thereof, and nucleic acid sequences encoding the protein and its fragments in the preparation of pharmaceutical preparations and in methods for repressing HIV gene expression are also disclosed.
Patients receive oral sorafenib twice daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
The present invention relates to a medicine for treating rheumatism and a preparation method thereof, more specifically to a medicine mainly treating rheumatic cold diseases and a preparation method thereof. The medicine is named Biantianfengshiqing. The medicine is prepared from 12 Chinese medicines such as prepared nux vomica, scorpion, centipede, earthworm, gastrodia tuber, prepared fleece flower root, Chinese angelica, prepared frankincense, prepared myrrh, cyathula root, atractylodes rhizome and licorice. The preparation method of the medicine is simple; particularly, the processing method of the nux vomica is simpler than that in the prior art; the preparation method has the advantages of time saving and labor saving. Clinical practices in the past about score years prove that the medicine has specific effects on rheumatic cold diseases, particularly on aching pain, pain, numbness, adynamia, etc. in the whole body and the joints of both knees in rainy days. The cure rate is 90%, and the effective rate is higher than 98%.
The Senior Change Makers Physical Activity Program consists of weekly meetings, 1 hour each, for 8 weeks. The program provides participants with information about safe physical activity, strategies to increase physical activity, and guided walks. Topics will focus on walking, but we will also include information and activities relating to strength training, flexibility, and balance. Behavioral skills such as goal setting, addressing barriers, and social support will also be addressed.
During the first 2 hours of their chemotherapy infusions, participants will pedaling for 30 minutes using a stationary cycle ergometer. Participants will be allowed to determine their pedaling intensity and cadence, however, will be encouraged to reach the established goal intensity level. Additionally, subjects will complete both a physical activity questionnaire (International Physical Activity Questionnaire) and a quality of life questionnaire (European Organization for Research and Treatment of Cancer QLQ - CR 29) at baseline and following their last chemotherapy treatment. A questionnaire on chemotherapy side effects (Memorial Symptom Assessment Scale) will be gathered at baseline, during chemotherapy cycles 3, 6, and/or 12, and following completion of chemotherapy treatment. Lastly, muscular strength and physical performance will be measured via grip strength tests and TGUG tests within 2-4 weeks of the post-surgery and chemotherapy completion CT scans.
(See chart below for quantitative information.)

Potassium Chloride in 5% Dextrose Injection USP is sterile, nonpyrogenic solution for fluid and electrolyte replenishment and caloric supply. It contains no bacteriostatic or antimicrobial agents. This product is intended for intravenous administration.

The formulas of the active ingredients are:

Dextrose is derived from corn.

The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers and exhibits virtually no leachables. The solution contact layer is a rubberized copolymer of ethylene and propylene. The container is nontoxic and biologically inert. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary.
In a double-blind, clinical trial, 1,443 subjects with recurrent labial herpes were randomized to receive XERESE, 5% acyclovir in XERESE vehicle or vehicle alone. Subjects had, on average, 5.6 episodes of herpes labialis in the previous 12 months. The median age was 44 years (range 18 to 80 years), 72% were female, and 91% were Caucasian. Subjects were instructed to initiate treatment within 1 hour of noticing signs or symptoms and continue treatment for 5 days, with application of study medication 5 times per day. Ulcerative cold sores occurred in 58% of the subjects treated with XERESE compared to 74% in subjects treated with vehicle and 65% in subjects treated with 5% acyclovir in XERESE vehicle. The mean time to skin normalization was approximately 1.6 days shorter in the subjects treated with XERESE compared to vehicle. Clinical signs in terms of size of the cold sore and symptoms such as tenderness were reduced with XERESE as compared to vehicle.