anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Intra-abdominal drains are often placed in emergency gastrointestinal surgery procedures with the aim to prevent the formation of intra-abdominal collections (IAC) and aid in their early detection. However, the evidence for this is debated. This scoping review aims to evaluate the current evidence for their use in this setting.
METHODS: A literature search was performed using MEDLINE via PubMed, Scopus, Web of Science, Cochrane Library, and ClinicalTrials.gov. Primary studies published between January 2000 and September 2023 that assessed intra-abdominal drain placement and post-operative IAC formation in emergency gastrointestinal surgery were included.
RESULTS: A total of 26 articles were identified. There was no strong evidence to suggest that prophylactic intra-abdominal drain placement influences the formation of IAC in emergency gastrointestinal procedures. There was a suggestion that drain placement may increase the rate of surgical site infection and length of hospital stay. However, current studies on the topic are of poor quality and high risk of bias.
CONCLUSION: The undifferentiated use of drains in emergency gastrointestinal surgery should not be encouraged. Drain placement should be specific to the clinical context. Higher quality research is warranted to better understand the influence drain placement has on post-operative outcomes.
The invention discloses traditional Chinese medicine preparation for treating lumbar intervertebral disc protrusion. Selected raw medicaments respectively comprise angelica sinensis, fried szechuan lovage rhizome, raw rehmannia root, prepared rehmannia root, peach kernel, red flower, red paeony root, bitter orange, bupleurum falcatum, eucommia bark, rhizoma cibotii, scorpio, earthworm, ground beeltle, centipede, rhizoma corydalis, trogopterus dung, barbary wolfberry fruit, dogwood, salvia miltiorrhiza bunge, astragalus mongholicus, asarum, radix aconiti preparata, radix aconiti agrestis praeparata and liquorice. The preparation comprises a pill, a tablet, oral liquid preparation, capsule preparation and preferably honey pill preparation which are prepared by applying the traditional preparation process or modern preparation process,. The selected medicaments jointly take the effects of invigorating blood, stimulating menstrual flow, replenishing vital essence, benefiting marrow, eliminating stasis, relieving pain, clearing heat, cooling blood, detoxifying, dissipating stagnation and nourishing liver and kidney together. The traditional Chinese medicine preparation has favorable curative effect on lumbar intervertebral disc protrusion caused by various reasons. The invention has the advantages of rapid action, obvious therapeutic effect, high tolerance, low cost and no any toxic or side effect.
BACKGROUND: Cardiac magnetic resonance (CMR) allows comprehensive myocardial tissue characterisation, revealing areas of myocardial inflammation or fibrosis that may predispose to ventricular arrhythmias (VAs). With this study, we aimed to estimate the prevalence of structural heart disease (SHD) and decipher the prognostic implications of CMR in selected patients presenting with significant VAs.
METHODS: Electronic databases were searched for studies enrolling adult patients that underwent CMR for diagnostic or prognostic purposes in the setting of significant VAs. A random effects model meta-analysis of proportions was performed to estimate the prevalence of SHD. HRs were pooled together in order to evaluate the prognostic value of CMR.
RESULTS: The prevalence of SHD was reported in 18 studies. In all-comers with significant VAs, the pooled rate of SHD post-CMR evaluation was 39% (24% in the subgroup of premature ventricular contractions and/or non-sustained ventricular tachycardia vs 63% in the subgroup of more complex VAs). A change in diagnosis after use of CMR ranged from 21% to 66% with a pooled average of 35% (29%-41%). A non-ischaemic cardiomyopathy was the most frequently identified SHD (56%), followed by ischaemic heart disease (21%) and hypertrophic cardiomyopathy (5%). After pooling together data from six studies, we found that the presence of late gadolinium enhancement was associated with increased risk of major adverse outcomes in patients with significant VAs (pooled HR: 1.79; 95% CI 1.33 to 2.42).
CONCLUSION: CMR is a valuable tool in the diagnostic and prognostic evaluation of patients with VAs. CMR should be considered early after initial evaluation in the diagnostic algorithm for VAs of unclear aetiology as this strategy may also define prognosis and improve risk stratification.
Participants have mild renal impairment (creatinine clearance (CLcr) = 51 to 80 mL/min). Participants treated with one dose of plerixafor (240 µg/kg) administered by subcutaneous (SC) injection.
FIELD: biotechnology, medicine, pharmacy. SUBSTANCE: follicle-stimulating hormone (FSH) containing α-subunit of gonadotropin and β-subunit consisting of 111 amino acids is isolated from climacteric urine. FSH does not contain luteinizing hormone and has activity 6200 IU FSH/mg lyophilized powder, not less. FSH is glycosylized. The isolated FSH is used in pharmaceutical composition for subcutaneous administration. EFFECT: improved quality of hormone. 6 cl, 1 dwg
INTRODUCTION: Klebsiella pneumoniae can cause a wide range of infections. Hypervirulent K. pneumoniae (hvKp), particularly associated with the K1 and K2 capsular types, is an increasingly significant microorganism with the potential to cause invasive infections, including renal abscesses. Despite the rising prevalence of hvKp infections, information on renal abscesses caused by K. pneumoniae is limited, and the clinical significance of hvKp associated with specific virulence genes remains elusive.
METHODS: This study performed at a 1200-bed tertiary hospital sought to identify the clinical and microbiological characteristics of renal abscesses caused by K. pneumoniae, focusing on various virulence genes, including capsular serotypes and multilocus sequence typing (MLST).
RESULTS: Over an 8-year period, 64 patients with suspected renal abscesses were reviewed. Ten patients diagnosed with K. pneumoniae-related renal abscesses were ultimately enrolled in the study. Among the isolates from the 10 patients, capsular serotype K2 was predominant (40.0%), followed by K1 (30.0%). The most common sequence type by MLST was 23 (40.0%). In particular, six patients (60.0%) harbored specific genes indicative of hvKp: iucA, peg-344, rmpA, and rmpA2.
CONCLUSIONS: Our findings highlight the importance of hvKp as a pathogen in renal abscesses. Although the nature of hvKp is relatively unknown, it is widely recognized as a highly virulent pathogen that can infect relatively healthy individuals of various ages and simultaneously cause infections at multiple anatomical sites. Therefore, when treating patients with K. pneumoniae-related renal abscesses, caution is necessary when considering the characteristics of hvKp, such as potential bacteremia, multi-organ abscess formation, and metastatic spread.
The program consist in a "Continuous High aerobic exercise and moderate intensity intervals" (ShoshanaB et al, 2012) combined with "muscular strength exercises and joint mobility". Patients come three times a week for six months to the primary health center. A fitness expert nurse is responsible for monitoring the performance and adapt to the physical condition of the patient.Each exercise session consists of warming up time period, period of work and back to calm. Exercise intensity during the work period increases progressively as the program progresses. Aerobic exercise is performed on a cycle ergometer or treadmill.Muscle strength exercises and joint mobility are performed with dumbbells and ankle weights adapted to each patient.
Unscheduled Bleeding and Spotting

Unscheduled (breakthrough or intracyclic) bleeding and spotting sometimes occur in patients on COCs, especially during the first three months of use. If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy. If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different contraceptive product.

In the clinical trial with levonorgestrel 0.1 mg and ethinyl estradiol 0.02 mg tablets breakthrough bleeding and spotting was reported in 4% and 12% of cycles, respectively. Breakthrough bleeding and spotting occurred together during 11% of the cycles.

Amenorrhea and Oligomenorrhea

Women who use Balcoltra may experience amenorrhea. In the clinical trial, 2.6% of the evaluable cycles were amenorrheic. Some women may experience amenorrhea or oligomenorrhea after discontinuation of COCs, especially when such a condition was preexistent. 

If scheduled (withdrawal) bleeding does not occur, consider the possibility of pregnancy. If the patient has not adhered to the prescribed dosing schedule (missed one or more active tablets or started taking them on a day later than she should have), consider the possibility of pregnancy at the time of the first missed period and take appropriate diagnostic measures. If the patient has adhered to the prescribed regimen and misses two consecutive periods, rule out pregnancy.
All patients (i.e. in both arms) with atopic dermatitis will be prescribed emollients and cleanser as a part of routine skin care. Topical corticosteroid (i.e. Fluticasone 0.05% cream) and topical calcineurin inhibitor (tacrolimus 0.1% ointment) for sensitive areas like periorbital regions, flexures and face, will be given once daily. All patients will be given an oral antihistamine (syrup/ tablet cetirizine 0.3mg/kg) at night. It is referred to as conventional treatment.
An aqueous preparation containing a mercaptan having a pH value greater than 7 and less than 10 is used for the treatment of hair or other keratin fibres as a preliminary to or during a waving, de-kinking or other shaping treatment.  The mercaptan advantageously carries substituents which render it monmalodorous and non-toxic and such substituents may be (a) acidic polar atoms or groups, e.g. halogen atoms or carboxylic, sulphonic, nitro or sulphato groups, (b) basic polar groups, e.g. amino or imino groups, or (c) non-polar groups, e.g. hydroxyl, aldehyde, ketone, carboxylic ester or ether groups.  Specified mercaptans are ethyl and benzyl mercaptans, thioglycollic acid, mercaptoethylsulphonic acid, b -aminoethyl mercaptan and its N-methyl and N-dimethyl derivatives, b -mercaptoacetone, mercaptoethyl acetate, b -mercaptoethyl ethyl ether, 3-amino-2-hydroxypropyl mercaptan, thioglycerols, trithiohexitols, di-, tri- and tetra - glycol dimercaptans, mercaptoethyloxyethylamine, trimercaptoethylamine, mono-, di- and poly-thiohydroxy acids, mercapto-di- and poly-carboxylic acids, mono-, di- and tri-thiomucic acids, mono- and dimercaptosuccinic acids, thiocitric acid, mercaptoamino acids, the a -mercaptomethyl derivatives of furane, thiophene, pyrrole and pyrimidine, thiofurfuryl alcohol, mercaptoalkyl-ureas, thioureas and isothioureas, mercaptoethylurethane, mercaptoethyl-acetamide, mercaptoethyl-guanidine and mercaptoalkyl-betaines and taurines. The pH of the mercaptan solution is adjusted to within the range 7.0-10.0, e.g. by addition of ammonia, methylamine or ethylamine. The mercaptan is subsequently removed from the hair &c. by rinsing with water, containing in some cases sodium hypochlorite, chlorine, hydrogen peroxide or tartaric acid.  Mercaptoethylhydroxyethylamine is made by reacting diethanolamine with mercaptoethylamine, or by the action of sodium hydrosulphide on Cl-CH2.CH2.NH.CH2.CH2.OH. Thiocitric acid is prepared by treating citric acid with dry hydrochloric acid and then with sodium hydrosulphide.  a -Mercaptomethyl-furane is prepared by treating furfuryl bromide with sodium hydrosulphide.  Mercaptoalkyl ureas are prepared by the action of sodium hydrosulphide on a bromalkyl urea, which is itself made from the isocyanate of the alkanolamine.  Mercaptoalkyl thioureas are prepared by treating a bromoalkyl thiourea with sodium hydrosulphide. Alpha-hydroxy-thiophene is prepared by the action of formaldehyde on the Grignard reagent from alpha bromo thiophene.  Mercapto ethylsulphonic acid is prepared by oxidizing OH.CH2.CH2.SH to OH.CH3.CH2. SO3H, treatment with bromine and then with sodium hydrosulphide.
Aggressive therapy of diabetic kidney disease (DKD) can not only slow the progression of DKD to renal failure but, if utilized at an early enough stage of DKD, can also stabilize and/or reverse the decline in renal function. The currently recognized standard of therapy for DKD is blockade of the renin-angiotensin system with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). However, unless utilized at a very early stage, monotherapy with these drugs in DKD will only prevent or slow the progression of DKD and will neither stabilize nor reverse the progression of DKD to renal decompensation. Recently, the addition of a sodium-glucose cotransporter-2 inhibitor and/or a mineralocorticoid receptor blocker to ACE inhibitors or ARBs has been clearly shown to further decelerate the decline in renal function. The use of glucagon-like peptide-1 (GLP-1) agonists shown promise in decelerating the progression of DKD. Other drugs that may aid in the deceleration the progression of DKD are dipeptidyl peptidase-4 inhibitors, pentoxifylline, statins, and vasodilating beta blockers. Therefore, aggressive therapy with combinations of these drugs (stacking) should improve the preservation of renal function in DKD.
Subacromial surgery of the shoulder is performed often. It concerns space creating interventions (open and arthroscopic subacromial decompression) and rotator cuff surgery (open and arthroscopic). In this kind of surgery good wound healing and tissue recovery is of great importance to achieve optimal results. Wound healing disorders, pain and the formation of adhesions may negatively influence the postoperative course and lead to extended rehabilitation. This has an unfavourable influence on the personal well being of the patient and the possibility to return to labour. Especially in cuff surgery the course is strongly influenced by the healing of the attachment of the cuff to the bone. Besides the development of minimal invasive techniques, it's necessary to look for possibilities to decrease the morbidity of these procedures. Recent studies show that growth factors play a major role in wound healing. This concerns particularly TFG-B (transforming growth factor B) and PDGF (platelet derived growth factor) present in thrombocytes. They act as chemotactic agents for polymorphonuclear leucocytes, macrophages, fibroblasts and lymphocytes. Both growth factors stimulate the wound healing and cause improved angiogenesis and fibroplasia. They also play a role in wound retraction and remodelling. In animal-experimental models it is proved that the application of TGF-B and PDGF improves woundhealing and leads to better mechanical properties of the scar tissue. Faster and better wound healing and decreased development of adhesions after subacromial surgery can possibly be influenced favourably by using thrombocyte concentrate. In the treatment with autologous thrombocyte concentrate a thrombocyte rich concentrate is obtained by a centrifuging method (Gravitational Platelet System (GPS), Biomet, Warsaw USA) (platelet rich plasma or PRP), that can be applied in the operating field. The concentrate is harvest from the patients own blood, sampled during the procedure. At random the concentrated is applicated and both groups are compared postoperatively.
The invention belongs to the field of chemical medicine, and particularly relates to benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives, and a preparation method and application thereof. The structure of the benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives is disclosed as Formula I. The invention also provides a preparation method and application of the benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives. The benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives provided by the invention have obvious inhibiting activity for RIP1 kinase, and have obvious effects on in-vivo therapy of ischemic myocardial cell necrosis. The derivatives have favorable solubility, and have greatly higher properties than the Nec-series compounds in the aspects of curative effect and pharmaceutical properties. The synthesis method of the benzyl-1H-pyrazole and benzyl-1H-pyrazole derivatives is simple, and is suitable for large-scale production.
Sham transcranial Direct Current Stimulation (tDCS): Effective stimulation of 1.5 mA for 30 seconds, then the current is switched off. The complete session lasts 30 minutes, with 29 minutes and 30 seconds without stimulation.
BACKGROUND: Many individuals diagnosed with lung cancer suffer from tremendous pain, and it is crucial to implement more effective measures to assist these patients in alleviating their pain. The present study utilizes a meta-analysis to evaluate the safety and efficacy of acupuncture combined with opioids for treating lung cancer-related pain in patients.
METHODS: We have searched 8 electronic databases: The Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and SinoMed. We included all randomized controlled trials of acupuncture combined with opioids for lung cancer-related pain in adults. We observed the main outcome indicators, including pain relief rates, numeric rating scale scores, and adverse events. Two researchers independently conducted literature screening, literature data extraction, and assessment of bias risk in the literature quality. Any disagreements were resolved through discussions between the 2 researchers or consultations with a third researcher. The risk of bias in the included studies was assessed using the revised risk of bias assessment tool. The overall quality of evidence for each outcome was evaluated using Grading of Recommendations, Assessment, Development and Evaluations.
RESULTS: We retrieved 812 lung cancer patients from 11 trials. The study showed that compared to opioids alone, the combination of acupuncture and opioids significantly reduced numeric rating scale scores, increased pain relief rates, and decreased the occurrence of side effects.
CONCLUSION: The current evidence indicates that combining acupuncture with opioid analgesics is superior to using opioid analgesics alone for managing lung cancer-related pain. Additionally, this combination therapy has fewer adverse reactions.
FIELD: medicine. SUBSTANCE: method involves carrying out ultrasonic examination of the mammary glands before making operation. Isolated microcalcinates availability or lack is tested in the tumor. Polychemotherapy course is applied. The following ultrasonic examination is carried out 10-14 days later with respect to its end. Isolated microcalcinates availability when previously absent or their increase in number to multiple when being available earlier as isolated components in the ultrasonic examination, being observed, gives evidence as criterion of tumor sensitivity to the administered therapy. EFFECT: objective evaluation of treatment effectiveness; enhanced effectiveness in making treatment corrections. 12 dwg, 1 tbl
The ability of long duration therapeutic ultrasound to reduce pain, increase strength, and improve quality of life for patients with tendon injury \[e.g. tendinopathy of the elbow (medial or lateral\], Achilles tendon, or patellar tendon) will be assessed. During the 7-week protocol, participants will receive 4 continuous hours of therapy daily.

For the first week, baseline data will be collected as participants report pain scores (VAS) in the morning, noon, and night. During the next 6 weeks, participants will self-apply the device each day and record their pain score (VAS) before and treatment; and record their pain score (VAS) while performing specified movements designed to evaluate tendon rehabilitation. At bi-weekly site visits, strength measurements will be performed on the injured and uninjured limb. Participants will also complete a standardized questionnaire to assess disability due to the specific tendon injury at baseline and study conclusion.
PURPOSE:To obtain a new nucleotide useful for curing and preventing AIDS diseases and having excellent antiviral activities, especially a specific inhibiting activity against an AIDS virus (HIV-1) and specifically inhibiting their proliferation. CONSTITUTION:A new compound is expressed by the formula [(n) is 1-7, preferably an integer; B is independently a nucleic acid base in each nucleic acid unit. X is independently S and O atom, preferably all Xs are S; Here, at least one of Xs is S] or its salt. Here, as for a base arrangement of the compound of the formula I, the one which has guanine (G) at the fourth position from the 5' end is preferable. More preferable arrangements are a group of TGGGAG (T is thymine; A is adenine). CGGGAGG (C is cytosine), etc. Specifically preferable arrangements are expressed by a group of TGGGAG, TGGGA, etc. E.g. AATGGGAGG, etc. The compound of the formula can be obtained by the photosphorodiamide method.
The present invention discloses medicine for treating rheumatic and rheumatoid diseases, which uses Chinese angelica, gastrodia tubers, fleece-flower roots, ledebouriella roots, pubescent angelica roots, achyranthes roots, oysters, dendrobe, honeysuckle stems, chuanxiong rhizomes, large-leaf gentian roots, homalomena occulta, dipsacus roots, raw eucommia barks, water plantain, mistletoe, nodular branches of pines, cibot rhizomes, magnolia barks, cassia twigs, cortex illicii, licorice roots, etc. as raw materials. The raw materials are decocted and concentrated to prepare oral liquid or are immersed to prepare medicated wine. The formula of the medicine does not have poisonous medicine materials. The medicine has no toxic and side effects, and has internal and external treatment functions. The medicine also has the functions for treating diseases in bones and muscle, regulating breath, removing abdominal distention, eliminating viruses and nourishing livers and kidneys. The medicine can be taken for a long time. No adverse reaction appears after the administration of the medicine. The medicine has the advantage of low preparation cost.
Participants in this arm will receive the C4 intervention, along with the 3MV (Many Men, Many Voices) behavioral intervention. The 3MV program aims to reduce stigma, promote safer behaviors, and increase self-efficacy. This arm integrates both structural and behavioral approaches to enhance PrEP adherence. Participants will complete counseling sessions, group activities, and DBS testing for monitoring adherence.
PURPOSE:To obtain healthy tea having extremely improved utility efficiency of calcium component, standing long-term preservation, by blending medicinal plant powder heat-treated at a specific temperature with a calcium component heat-treated at a specific temperature in a specific ratio. CONSTITUTION:Several kinds of medicinal plants are powdered, the powdered several kinds of medicinal plants are blended to give medicinal plant powder, which is heated at about 300 deg.C for 3-4 minutes. On the other hand, a calcium component such as shell, bone of fish or egg shell is dried, powdered, the powdered calcium component is heat-treated at about 300 deg.C for 3-4 minutes. Then about 80% of the medicinal plant powder is mixed with about 20% of the calcium component powder to produce a healthy drink. The healthy drink is dissolved in water in the approximately same state of both the raw materials and utility efficiency of calcium is much more improved than existing healthy tea. Since the healthy tea is treated at a high temperature, the healthy tea is sterilized, stands long-term preservation and is drinkable in an unchanged quality for a long period of time.