anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer's disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD. Our results showed that the hippocampus and amygdala exhibit the most severe atrophy, followed by the temporal, frontal, and occipital lobes in mild cognitive impairment (MCI) and AD. The extent of atrophy in MCI was less severe than that in AD. A series of biological processes related to the glutamate signaling pathway, cellular stress response, and synapse structure and function were investigated through gene set enrichment analysis. Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy, providing new insight for further clinical research on AD.
The present disclosure discloses a multi-functional compact and handheld wireless multi-parameter health care monitoring device i.e., easily hand carried weighing less than 500-700 grams. The handheld device enables the user to capture and measure multiple health parameters using respective in-built sensors. The wireless health care monitoring device further incorporates with an enhanced touch screen display with single application activation feature which disables or de-activates other functions or sensors when one function in process. The handheld device used by any individual can be controlled and operated at remote locations without electricity through wireless communication interface and helps in time of emergency as multiple measurements are integrated. The handheld device can be operated using both manually using a display or remotely from an application through wireless interface like Bluetooth, Wi-Fi and thereof. The handheld device incorporate a mechanism to scan the QR code of any government identification such as Aadhar and map the captured health parameters with the decoded id and upload to cloud server thereby preventing unnecessary errors in demographics capture.
There have been reports of convulsions in adult and pediatric patients receiving cyclosporine, particularly in combination with high dose methylprednisolone. 

Encephalopathy, including Posterior Reversible Encephalopathy Syndrome (PRES), has been described both in post-marketing reports and in the literature. Manifestations include impaired consciousness, convulsions, visual disturbances (including blindness), loss of motor function, movement disorders and psychiatric disturbances. In many cases, changes in the white matter have been detected using imaging techniques and pathologic specimens. Predisposing factors, such as hypertension, hypomagnesemia, hypocholesterolemia, high-dose corticosteroids, high cyclosporine blood concentrations, and graft-versus-host disease, have been noted in many but not all of the reported cases. The changes in most cases have been reversible upon discontinuation of cyclosporine, and in some cases improvement was noted after reduction of dose. It appears that patients receiving liver transplant are more susceptible to encephalopathy than those receiving kidney transplant. Another rare manifestation of cyclosporine-induced neurotoxicity, occurring in transplant patients more frequently than in other indications, is optic disc edema including papilloedema, with possible visual impairment, secondary to benign intracranial hypertension. 

Care should be taken in using cyclosporine with nephrotoxic drugs (see PRECAUTIONS).
A vehicle display unit is designed to be carried by an automotive vehicle. Some such units are designed for mounting on the roof of a car, bus, or other vehicle. Others are designed to be mounted in other locations on or in a vehicle, such as, for example, on the side of a car, truck, or bus. Such a display unit can include components such as an one or more electronic displays; display drive circuitry, which can include a computer; a connection for receiving power from the electrical system of a vehicle; an enclosure around the one or more displays and their drive circuitry which has ventilation openings; and a ventilation fan for moving cooling air through the enclosure. The electronic displays can have 640×480 or greater resolution. Some roof-mounted embodiments have three electronic displays arranged in a triangle, with two displays each visible from the front and one side of the vehicle, and the third display visible from the behind the vehicle. Some roof-mounted embodiments include an enclosure for their display(s) and drive circuitry; one or more roof protectors having a weight distributing surface shaped to fit the curved roof of a vehicle on which they are mounted; and a plurality of mountings supported by the one or more roof protectors for suspending the enclosure in a position spaced above the roof, which mounting includes vibration isolators, for at least partially isolating the enclosure from vibration of the vehicle roof.
Epilepsy is a common neurologic disorder. While a good clinical solution is still missing, studies have confirmed that exosomes (Exos) derived from adipose-derived stem cells (ADSCs) had a therapeutic effect on various diseases, including neurological diseases. Therefore, this study aimed to reveal whether ADSC-Exo treatment could improve kainic acid (KA)-induced seizures in epileptic mice. ADSCs and Exos were isolated. Mice were generated with KA-induced epileptic seizures. ELISA was used to detect inflammatory factor expression. Luciferase reporter analysis detection showed a relationship among miR-23b-3p, STAT1, and glyoxylate reductase 1 (GlyR1). ADSC-Exos had a protective effect on KA-induced seizures by inhibiting inflammatory factor expression and the M1 microglia phenotype. The result showed that miR-23b-3p played an important role in the Exo-mediated protective effect in KA-induced seizures in epileptic mice by regulating STAT1 and GlyR1. Luciferase reporter analysis confirmed that miR-23b-3p interacted with the 3'-UTR of STAT1 and GlyR1. The miR-23b-3p inhibited M1 microglia-mediated inflammatory factor expression in microglial cells by regulating STAT1 and GlyR1. The downregulation of miR-23b-3p decreased the protective effect of ADSC-Exos on KA-induced seizures in epileptic mice. The miR-23b-3p from ADSC-Exos alleviated inflammation in mice with KA-induced epileptic seizures.
The invention discloses a new Gelsmium elegans Benth. alkaloid compound as well as a preparation method and application thereof. In the preparation method, a target compound is separated from Gelsmium elegans Benth. by using a pH-zone-refining countercurrent chromatography and taking a total Gelsmium elegans Benth. alkaloid crude extract as a raw material and a high-speed counter-current chromatographic instrument as separation equipment; and the method has the advantages of large preparation amount, less sample loss and strong controllability, and is convenient and fast and is suitable for industrial production. By the determination of high-resolution mass spectrometry, ultraviolet spectrum, infrared spectrum, <1>H, <13>C-NMR (nuclear magnetic resonance) spectrum, <1>H-<1>HCOSY (correlation spectrometry), HSQC (heteronuclear single quantum coherence) spectrum and HMBC (heteronuclear multiple-bond correlation) spectrum, the new Gelsmium elegans Benth. alkaloid compound has the structure of a formula (I). A pharmacological test shows that the compound in the invention has dose dependence, powerful analgesic effect, less tolerance, addiction and side effect and treatment index far higher than that of total Gelsmium elegans Benth. alkaloid, can be used for preparing a novel powerful low-toxicity medicament or lead compound used for treating pain, and has definite industrial prospect.
Application of Sulfamylon 5% Solution and Silver Nitrate soaked dressings to two different burned area. Sites were then monitored for infections during hospitalization.
PURPOSE:To obtain an inhibitor of obesity having reducing action on fats and inhibitory action on absorption of saccharide by blending essence of Commiphora molmol Engl. as a main material with essence of Saussurea lappa Clanke, etc. CONSTITUTION:Essence of Commiphora molmol Engl. as a main material is blended with one or more of essences of Saussurea lappa Clanke, Gymnema sylestre and POOARE tea to give an inhibitor of obesity. Essence of Commiphora molmol Engl. is blended with essence of another additive, dried at low temperature, mixed with an excipient and tableted or granulated to prepare the inhibitor of obesity. The inhibitor of obesity gradually shows effects and has inhibitory effects on fatness without damaging physical strength.
It includes the steps of (1) preparing step; (2) anesthetizing step; (3) electrodes installing step; and (4) focal onset seizures inducing step. First, a live animal is anesthetized. The electrodes are installed on a working zone of its brain. A first chemical liquid is injected beneath the cerebral cortex of this animal. At two different times, a first electric stimulation and a second electric stimulation are activated by the controller respectively so as to generate a first and a second focal onset seizure accordingly. Thus, it can generate focal onset seizures. It is easy to change the electric stimulation position, numbers and type. In addition, the survival rate of a larger-sized animal after anesthesia is higher.
PURPOSE:To obtain a drug composition for external use, containing diclofenac or a salt thereof and nonionic surfactant having a specific HLB value, useful as an anti-inflammatory and analgesic agent, etc., and improved in percutaneous absorbability. CONSTITUTION:A composition for external use containing diclofenac or a salt thereof (e.g. a salt with Na, K or Ca) and a nonionic surfactant (e.g. sorbitan monostearate or glycerol monostearate) having <=14.5 HLB value. A base normally used as a gel base is employed as a base of the aforementioned drug for external use and normally composed of, e.g. a gelling agent and further water, a lower alcohol, a neutralizing agent and a cosolvent. A carboxyvinyl polymer, polyacrylic acid, etc., are cited as the gelling agent.
FIELD: organic chemistry. SUBSTANCE: synthesis of the end products is carried out by reaction of cyclodi- or trimerization of phenylacetic acid nitriles of the general formula IIor their mixture with nitriles of the general formulas III and IV R- C≡ N (III), R-C≡ N (IV) where Rand Ras indicated above by HCl following isolation of the end product where Rand R- H or one of their is group C[=NH]-Ror acylation with isolation of compound where NRR- acylamino-group, or hydrolysis and isolation of compound where NRR- amino- or acylamino-group, or by alkylation and preparing of compound where Rand R- a lower alkyl. Reaction is carried out preferably in the medium of aprotonic organic or inorganic solvent (dioxane, chloroform, phosphorus oxychloride). Necessary nitriles and halogen hydrogen can be prepared in situ from amides or aldoximes by action of phosphorus oxychloride. Method ensures to increase the yield of the end products from 72 to 87.5%. EFFECT: increased yield and assortment of 3-aminoisoquinoline derivatives. 3 cl, 1 tbl
The dose of prazosin hydrochloride capsules should be adjusted according to the patient’s individual blood pressure response. The following is a guide to its administration:

Initial Dose: 1 mg two or three times a day (see WARNINGS). 

Maintenance Dose: Dosage may be slowly increased to a total daily dose of 20 mg given in divided doses. The therapeutic dosages most commonly employed have ranged from 6 mg to 15 mg daily given in divided doses. Doses higher than 20 mg usually do not increase efficacy, however a few patients may benefit from further increases up to a daily dose of 40 mg given in divided doses. After initial titration some patients can be maintained adequately on a twice daily dosage regimen. 

Use With Other Drugs: When adding a diuretic or other antihypertensive agent, the dose of prazosin hydrochloride capsules should be reduced to 1 mg or 2 mg three times a day and retitration then carried out. 

Concomitant administration of prazosin hydrochloride capsules with a PDE-5 inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension; therefore, PDE-5 inhibitor therapy should be initiated at the lowest dose in patients taking prazosin hydrochloride capsules.
There is an urgent call for efficient and effective assessment, prevention, and intervention among older adults (age 50 and older) to reduce health risk of hazardous drinking, encourage healthy aging, and reduce burden on healthcare systems. Brief, low-burden, low-cost, digital interventions among older adults can answer this call. Text-messaging health interventions are considered an effective, scalable way to deliver behavioral health interventions, and they have been used as evidence-based solutions in primary care settings among older adults for behaviors other than alcohol use to supplement traditional care. Contrary to stereotypes, older adults use mobile technology, seek online and mobile interventions, and often engage longer compared to younger populations. The primary objective of the proposed study is to evaluate effectiveness of scalable, tailored text- messaging programs for alcohol use among older adults. This study focuses on gain and loss framing of behavior change goals (i.e., the positives of change and the negatives of remaining with the status quo), critical components of behavioral science and health behavioral interventions. Loss-framing is used to motivate individuals to avoid future problems by focusing on the consequences of no change in behavior, and gain-framing is used to facilitate progress by focusing on the benefits of change. The investigators will design and evaluate three text-messaging programs using a randomized controlled trial: (A) Loss-framed messaging (B) Gain-framed messaging; and (C) Combined (loss and gain) messaging among a sample of 150 older adults with hazardous drinking. Participants will be randomized to one of the three conditions, each of which will last 8 weeks. Participants will undergo cross- sectional online assessments (baseline, week 4, week 8 and week 16), and they will also complete a mobile assessment (via text message) once per week to track drinking. The effects of condition on drinking behavior will be compared at weeks 4, 8 and 16. In addition, attrition from the study will be closely tracked. Finally, the investigators will explore how the effects condition are impacted by gender and age (via moderation analysis).
INTRODUCTION: Like children with typical language development, their peers with developmental language disorder (DLD) are expected to learn English as a foreign language (EFL). For pupils without DLD, it is well-established that amount of informal exposure to English outside of the classroom, starting age of EFL instruction and motivation are strong positive predictors of EFL learning rate and/or achievement, whereas anxiety is negatively related to performance. This paper is the first attempt to investigate how these predictors of EFL performance operate in learners with DLD.
METHODS: Participants were nineteen Dutch-speaking 7th graders with DLD learning English as a school subject at a specialist education facility in the Netherlands. English receptive grammar and receptive vocabulary were measured twice, with a four-month interval. Foreign language learning motivation, anxiety and (length and amount of) informal exposure to and instruction in English were measured via questionnaires.
RESULTS: The participants did not show any progress on English vocabulary and grammar. At Time 1, vocabulary and grammar scores were positively related to starting age of EFL instruction and negatively related to anxiety. For vocabulary, achievement was also positively predicted by attitudes towards English lessons. Only the relationship between starting age of instruction and vocabulary outcomes was visible at Time 2. Amount and length of informal exposure to English did not predict performance, which is in stark contrast to the patterns observed in EFL learners with typical language development.
CONCLUSIONS: We conclude that children with DLD benefit from a later onset of foreign language lessons, whereas length and amount of out-of-school exposure to English are less important in the context of DLD, possibly due to difficulty with implicit learning.
The early symptoms of neurodegenerative diseases include oxidative stress disorder and accelerated inflammation levels. Edible fungi polysaccharides play essential roles in anti-neuroinflammation. We analyzed the regulatory mechanisms of polysaccharides from extracellular Armillariella tabescens (ATEP) in alleviating neuroinflammation in mice. Mice were induced with d-galactose and aluminum chloride to establish an animal model of Alzheimer's disease, then intragastrically treated with ATEP, which had been previously analyzed for its physicochemical properties. We assessed the critical characteristics of mice treated for neuroinflammation, including cognitive behavior, the anti-inflammatory potential of ATEP in hippocampal pathology and critical protein expression, and changes in fecal microbial composition and metabolites. ATEP intervened in oxidative stress by enhancing antioxidant enzyme activities and suppressing the Keap-1/Nrf2 signaling pathway. Changing the Nrf2 content in the nucleus led to changes in the downstream oxidation-related enzymes, HO-1, NQO-1, iNOS, and COX-2, and the neuronal morphology in CA3 region of the hippocampus. Microbiome analysis revealed that ATEP remodeled the gut microbiotas and regulated the short-chain fatty acids-producing bacteria. Early intervention with ATEP via active dietary supplementation may promote neuroprotection.
OBJECTIVES: There is a lack of data on the number of surgeries required for endoscopic combined intrarenal surgery (ECIRS). Accordingly, we aimed to identify the learning curve for ECIRS performed by multiple surgeons.
METHODS: We included 296 patients who underwent ECIRS at our university hospital between 2016 and 2021. A learning curve for percutaneous nephrolithotomy side was calculated considering urology-resident surgeons. The learning curve was retrospectively analyzed for surgical time, renal puncture time, stone-free rate, and complications and corrected for age, body mass index, stone size, computed tomography value, cumulative number of surgeries, and stone location.
RESULTS: This study included cases performed by 32 surgeons, including 30 residents and 2 attending surgeons. The median number of surgeries performed by the residents and attending surgeons prior to this study was 4.5 and 90, respectively. The median number of surgical procedures performed during the training period was seven. The surgical time of the residents decreased as the number of cases increased, reaching a median surgical time of 111 min for the attending surgeons after 16.4 cases. Renal puncture time was achieved in 20.1 cases. Complications related to renal access were observed in 13.0% (34 patients), Clavien-Dindo grade II in 1.9% (5 patients), and grade III or higher in 0.8% (2 patients). Comparing the first to fifth cases with the 21st and subsequent cases, the complication rate improved from 35% to 13%.
CONCLUSION: Our study demonstrated that ECIRS training provided 16-20 cases with a learning curve to achieve acceptable surgical outcomes.
Multiple myeloma (MM) is the second most common malignant tumor of the hematological system, accounting for 10% of all hematological malignancies. With the emergence of new drugs such as proteasome inhibitors and immunomodulators, the efficacy of MM has been significantly improved, and the progression-free survival rate and overall survival rate of patients have been significantly improved. However, due to primary or secondary drug resistance, MM is still incurable , and patients will eventually be relapsed and refractory. At present, most first-line treatments contain proteasome inhibitors and immunomodulators at the same time, and patients are often resistant to these two types of drugs. CD38 monoclonal antibody is a new drug that was launched two years ago, but the price is too high, roughly 500,000 yuan a year, and most patients cannot afford it. At present, new drugs available to patients in China is still very limited, and investigator urgently need to find new treatment options among the existing drugs in China to prolong the lives of patients. Bendamustine is an alkylating agent and is currently mainly used in the treatment of lymphoma in China. But in Europe, bendamustine has been approved as a MM drug. The NCCN guidelines also include bendamustine + proteasome inhibitors or immunomodulators + hormones as the recommended treatment for MM. Because most of the patients with relapse and refractory MM have been resistant to proteasome inhibitors and immunomodulators, investigator found that the NCCN guidelines recommended schemes are not effective when used in these patients. Therefore, investigator tried to combine bendamustine with liposomes and dexamethasone (BAd) to treat relapsed and refractory MM. At present, 3 patients have been treated with this program, all of which are multi-line recurrences. Among them, 1 patient achieved complete response (CR) after 2 courses of treatment. At present, 6 courses of treatment have been completed and have been in CR state. The other 2 cases achieved partial response, and the total response rate reached 100%. The common adverse reaction in patients was hematological toxicity, but they were all tolerated. No patient stopped the drug due to adverse reactions. The price of bendamustine per course of treatment is roughly between 6000-8000 yuan, which patients can basically afford. Therefore, the program is feasible in terms of effectiveness, economy and safety. Due to the small number of patients, investigator need to further expand the number of samples to observe the optimal dose, efficacy and adverse reactions of the drug. If the program is validated and feasible, it will benefit more patients, extend their lives as much as possible, and have the opportunity to wait for other new drugs to come out.
BACKGROUND AND AIMS: liver stiffness measurement, assessed by vibration-controlled transient elastography, has been recognized as a powerful tool for liver fibrosis assessment. The potential of liver stiffness measurement to predict clinically relevant outcomes in fatty liver disease has received considerable attention. This study aimed to investigate the prediction of liver-related events in metabolic dysfunction-associated steatotic liver disease patients by liver stiffness measurement value on transient elastography.
METHODS: the electronic databases including PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov until 6 September 2023 were systematically searched. The hazard ratios adjusted for confounders were extracted and pooled by random-effects model analysis.
RESULTS: a total of 20,587 individuals from seven studies were included. The pooled hazard ratios (HRs) were 18.65 (95 % CI: 9.95-34.95, p < 0.01, I2 = 0 %) in the stratification analysis of the highest versus lowest liver stiffness measurement categories. In 1-kPa analysis, the risk of liver-related events was increased with 1 kPa increment (HR 1.05, 95 % CI: 1.03-1.07, p < 0.01, I2 = 74.47 %).
CONCLUSIONS: metabolic dysfunction-associated steatotic liver disease patients with high liver stiffness measurement values were at an increased risk of liver-related events. Liver stiffness measurement can be used as a prognostic tool to achieve risk stratification in fatty liver patients.