anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present disclosure relates to system and method facilitating healthcare services. 
     Plurality of designated portals are designed for providing the healthcare services. Request including learning request or consult request for availing a healthcare service through one or more providers is received by a user. Learning request and the consult request are directed to a designated portal selected by the user. Designated portal controls display of the details of the user to the one or more providers, according to the learning request or the consult request. Request results are generated for the learning request and the consult request, through the designated portal. The request result is generated in a preselected mode of access and according to a user's preference, such that the user avails the healthcare services by accessing the request result.
These patients must have a definite diagnosis of type 2 diabetes mellitus (T2DM) according to the American Diabetes Association (ADA) standards. Some of these patients have symptoms of cognitive impairment, while others have normal cognition. All T2DM patients will undergo physical exam, cognitive and olfactory test as well as structural and brain functional MRI at baseline and follow-up time points.
Motor imagery (MI) is the mental representation of movement without any real body movement. MI is a complex and cognitive process involving the use of sensory and perceptual memories related to motor movements.Various studies using brain imaging techniques have found that during motor imagery, brain areas similar to voluntary movement are activated or the motor cortex can be stimulated. These findings suggest that stroke patients who cannot physically move their limbs can stimulate brain regions responsible for motor movements using motor imagery. The Kinesthetic and Visual Imaginery Questionnaire (KVIQ) is a motor imagery questionnaire developed for people who need to be guided for different reasons and cannot perform complex movements. Evaluate both visual and kinesthetic dimensions of motor images. This study was planned because of the need for evaluation of motor imagery for stroke patients, who mostly have motor and sensory problems.
1430958 6,14-Endo-ethe(a)ne-tetrahydro nororipavines and thebanes BOEHRINGER INGELHEIM GmbH 18 June 1973 [19 June 1972] 28870/73 Heading C2C Novel compounds I in which R is hydrogen, methyl or acetyl, R 1  is hydrogen, methyl or phenyl, Z is -CH = CH- or -CH 2 -CH 2 -, Y is oxygen or sulphur and R 3  is hydrogen or methyl and their acid addition salts are prepared by (1) reacting a compound II with a compound III in which X is an atom or group removable as an anion and is preferably halogen, tosyl or trialkylammonium, (2) cleaving a compound IV in which R is hydrogen or methyl and R 4  and R 5  are C 1-10  alkyl or aryl, or together are C 2-8  alkylene to form a Compound I (R=H or Me), (3) reacting a compound II with thiophene, furan, methyl thiophene or methyl furan and formaldehyde, (4) reacting a compound II with a compound VI in the presence of formic acid, (5) reducing a compound I in which Z is -CH=CH- to that in which Z is -OH 2 -CH 2 -, (6) reaction of a compound VII with an aldehyde CH 2  = CH-CO-R 1  to form a compound I (Z=-CH=CH-), (7) cleaving a protecting group "Sch" (which represents an alkyl aralkyl or ester group) in a compound I in which R is "Sch" to form a compound in which R is hydrogen or (8) methylation or acetylation of a compound I in which R is hydrogen. Compounds IV are produced by reacting a ketal XII in which R is hydrogen or methyl (prepared by demethylation using bromo cyanogen) with an acyl derivative XIV in which X is chlorine and reduction of the resulting amide with lithium aluminium hydride. Compounds VII may be analogously prepared starting from nor-thebane or nororipavine. Compounds I are analgesics and anti-tussives and exhibit morphine antagonism. They form with a carrier or excipient a pharmaceutical composition which may be administered orally or parenterally. The compositions may contain other analogous agents or sedatives, tranquillizers or hypnotics.
For each participant in the functional electrical stimulation (FES) group, standard rehabilitation (SR) in addition two dual-channel FES stimulators (MEDTRONIC Respond Select; EmpiInc) were used. The FES was delivered with 0.3-ms pulses at 30 pps and the stimulation intensity was set to the movement threshold to induce visible muscle contractions. For the FES group, the given electric stimulation treatment lasted for 30 min per session, once per day, 5 days a week, for 2 weeks.
Up to 60 participants will be recruited for the intervention group. Participants will receive the current standard of care DM education for insulin at Northwestern Memorial Hospital and the adjunctive education with the DM Discharge Toolkit.
INTRODUCTION: Radiofrequency ablation (RFA) is a widely accepted, minimally invasive treatment modality for patients with hepatocellular carcinoma (HCC). Accurate prognosis prediction is important to identify patients at high risk for cancer progression/recurrence after RFA. Recently, state-of-the-art transformer models showing improved performance over existing deep learning-based models have been developed in several fields. This study was aimed at developing and validating a transformer model to predict the overall survival in HCC patients with treated by RFA.
METHODS: We enrolled a total of 1778 treatment-naïve HCC patients treated by RFA as the first-line treatment. We developed a transformer-based machine learning model to predict the overall survival in the HCC patients treated by RFA and compared its predictive performance with that of a deep learning-based model. Model performance was evaluated by determining the Harrel's c-index and validated externally by the split-sample method.
RESULTS: The Harrel's c-index of the transformer-based model was 0.69, indicating its better discrimination performance than that of the deep learning model (Harrel's c-index, 0.60) in the external validation cohort. The transformer model showed a high discriminative ability for stratifying the external validation cohort into two or three different risk groups (p < 0.001 for both risk groupings). The model also enabled output of a personalized cumulative recurrence prediction curve for each patient.
CONCLUSIONS: We developed a novel transformer model for personalized prediction of the overall survival in HCC patients after RFA treatment. The current model may offer a personalized survival prediction schema for patients with HCC undergoing RFA treatment.
Near-tetraploidy/tetraploidy (NT/T) is a cytogenetic alteration in acute myeloid leukemia (AML). In AML, specific chromosomal alterations are associated with clinical, morphological, and immunophenotypic features. The impact of cytogenetics on the prognosis of AML is well established. However, the prognostic implication of NT/T on AML remains unclear. Our aim is to further characterize the clinical, morphologic, immunophenotypic, molecular mutational, and prognostic features of NT/T AML. This retrospective chart review of NT/T AML cases showed NT/T AML was more common in older adult males, with predominately large blasts and myelodysplasia-related features. The most common lineage of dysplasia was dysgranulopoiesis in 77.8% of cases. Cases displayed multiple cytogenetic abnormalities, with only four showing NT/T as the sole abnormality. TP53 was the most common molecular mutation associated with NT/T AML (44.5%). Of the patients receiving treatment for NT/T AML, 80% achieved a CR. The median overall survival for the entire cohort was 4.5 months.
Tumour cell dormancy is critical for metastasis and resistance to chemoradiotherapy. Polyploid giant cancer cells (PGCCs) with giant or multiple nuclei and high DNA content have the properties of cancer stem cell and single PGCCs can individually generate tumours in immunodeficient mice. PGCCs represent a dormant form of cancer cells that survive harsh tumour conditions and contribute to tumour recurrence. Hypoxic mimics, chemotherapeutics, radiation and cytotoxic traditional Chinese medicines can induce PGCCs formation through endoreduplication and/or cell fusion. After incubation, dormant PGCCs can recover from the treatment and produce daughter cells with strong proliferative, migratory and invasive abilities via asymmetric cell division. Additionally, PGCCs can resist hypoxia or chemical stress and have a distinct protein signature that involves chromatin remodelling and cell cycle regulation. Dormant PGCCs form the cellular basis for therapeutic resistance, metastatic cascade and disease recurrence. This review summarises regulatory mechanisms governing dormant cancer cells entry and exit of dormancy, which may be used by PGCCs, and potential therapeutic strategies for targeting PGCCs.
INTRODUCTION: When examining health literacy and disease specific knowledge levels across ethnicities and communities, ethnic minority groups are known to be at a higher risk of being below the average health literacy threshold which is a factor linked to poor health status and higher mortality rates. This study examined disease specific knowledge levels, perceived severity, and perceived susceptibility surrounding anal cancer and HPV-related screening behaviors.
METHODS: The following research questions were explored: (1) "What are the common themes and/or beliefs when asked about anal cancer, HPV, and preventive screening?" and (2) "What are the common themes and beliefs surrounding the severity and susceptibility of contracting anal cancer?". This study utilized a cross-sectional design to survey 26 individuals regarding their knowledge level and perspectives regarding anal cancer and HPV. An 8-question survey was developed de novo based on an application of the Health Belief Model (HBM) elements. This study employed thematic analysis to explore critical themes to construct a model to understand knowledge levels, attitudes, and risk perceptions regarding anal cancer and intention to participate in preventive screenings. The fundamental attitudes and themes related to anal cancer risk and intention to participate in preventative screenings were elicited using a qualitative descriptive technique. Coded data was utilized to analyze themes based on (1) knowledge and (2) perceived risk, both severity and susceptibility.
RESULTS: Overall, the findings indicate very low levels of knowledge regarding screening, anal cancer, and HPV across all genders. The low levels of anal cancer and HPV knowledge were seen in 13 coded segments (50% of surveys) which showed no familiarity with or comprehension of HPV, and 4 coded segments indicated no familiarity with anal cancer. In addition, 15 respondents (57%) had low or no preventive or screening-related knowledge. While some respondents (46%) illustrated high perceived severity for anal cancer, only 23% indicated high perceived susceptibility for anal cancer.
CONCLUSION: The results from this study may be used to inform practitioners, providers, and policymakers in developing interventions addressing low levels of understanding and disease specific knowledge surrounding anal cancer in support of creating a standardized health screening procedure.
Prior to the burn dressing changes PCA-DEX patients will receive a bolus of dexmedetomidine (Precedex®) 0.25 mcg/kg administered over 10mins by nurse staff, followed by a continuous infusion of Precedex® at 0.4 mcg/kg/hr via a standard infusion pump (LifeCare PCA). Patients will self-medicate as needed for anxiety self-management by self-administering a bolus of Precedex® 0.1 mcg/kg.
In the active and transitional phases, during contractions, performing exercises on the birth ball (fully rotating the hip, moving to the right/left, coming back and forth, and slightly bouncing while sitting on the birth ball) (average 25 minutes). In order to monitor the condition of the fetus, exercises on the birth ball were performed by the pregnant woman during contractions while connected to NST.
The slow released anticancer injection containing both phosphoinositide-3-kinase inhibitor and alkylating agent consists of slow released microsphere and solvent. The slow released microsphere includes effective anticancer component and slow releasing supplementary material, and the solvent is common solvent or special solvent containing suspending agent. The suspending agent is sodium carboxymethyl cellulose, etc. and has viscosity of 100-3000 cp at 20-30 deg.c. The effective anticancer component is the combination of phosphoinositide-3-kinase inhibitor and/or alkylating agent selected from melphalan, cyclophosphamide, etc. The slow releasing supplementary material is p(LAEG-EOP), p(DAPG-EOP), etc. The anticancer composition may be also prepared into slow released implanting agent for use alone or together with chemotherapeutic and/or radiotherapeutic medicine.
The mass media, and television in particular, hold significant potential as part of a population-wide strategy for bringing evidence-based parenting practices to a broad range of parents experiencing challenges raising their children. The potential of television for affecting parenting has received very little research attention, however; thus, little is known about how media messages to affect parenting practices might be optimally designed. This study will develop and experimentally evaluate two variants of a 10-episode, brief (12 minutes per episode), infotainment-style television series targeted at parenting practices, derived from the Triple P-Positive Parenting Program (Sanders, 1999). A sample of 300 families of children ages 3-6 years with somewhat elevated disruptive behavior problems will be randomized to (a) receive a standard "information-only" version of the series that includes only modeling and demonstration of target parenting skills, (b) receive an enhanced "behavior activation" version of the series designed to actively promote parental behavior change, through elements addressing attributions, self-efficacy and expectancies, social support, and emotional reactivity, or (c) a waitlist control group. Measures of parents' parenting practices, cognitions, affect, and social support, and children's disruptive behavior problems, will be obtained at baseline, post-intervention, and 6-month follow-up. The relative efficacy of the standard and enhanced versions of the Triple P Media Series in improving these outcomes will be examined, as well as moderators of these effects, such as baseline level of behavior problems and parental stress. This study will further our understanding of the potential value of television programming for improving parenting practices.
INTRODUCTION: Crohn's disease can present with complex surgical pathologies, posing a significant risk of morbidity and mortality for patients. The implementation of a loop ileostomy for selected patients may help minimize associated risks.
METHODS: In this retrospective cohort study, we investigated the utilization of temporary fecal diversion through the creation of a loop ileostomy in Crohn's surgery. Closure of all ostomies involved a hand-sewn single-layer technique. We then conducted bivariate analysis on 30-day outcomes for closures, focusing on favorable recovery defined as the restoration of bowel continuity without the occurrence of two challenges in recovery: newly developed organ dysfunction or the necessity for reoperation.
RESULTS: In total, 168 patients were included. The median age of the patients was 38 years (IQR 27-51). The most common indication for a loop ostomy was peritonitis (49%). After ileostomy closure, 163 patients (97%) achieved favorable recovery, while five encountered challenges; four (2.4%) underwent abdominal surgery, and one (0.6%) developed acute renal failure requiring dialysis. Two patients (1.2%) had a re-creation of ileostomy. Patients encountering challenges were older (56 [IQR 41-61] vs. 37 [IQR 27-50]; p 0.039) and more often required secondary intention wound healing (40% vs. 6.7%; p 0.049) and postoperative parenteral nutrition following their index surgery (83% vs. 26%; p 0.006).
CONCLUSION: Selectively staging the Crohn's disease operations with a loop ileostomy is a reliable practice with low morbidity and high restoration rates of bowel continuity. Our hand-sewn single-layer technique proves effective in achieving successful surgical recovery.
1,217,479. Dyeing hair. L'OREAL. 19 May, 1969 [17 May, 1968], No. 25531/69. Heading D1B. Compositions for dyeing keratinic fibres, e.g. human hair comprises a) at least one oxidation dye containing an aromatic or heterocyclic nucleus substituted by two amino groups, or by one amino group and one hydroxyl group which groups are ortho or para to one another and b) as coupling component at least one indoline having the formula I in which each of R and R2 which may be the same or different is a hydrogen atom, or an alkyl group of 1-6 carbon atoms, each of X, and X2 which may be the same or different is a hydrogen atom, a hydroxyl group or an amino group with the proviso that one of X1 and X2 represents a hydrogen atom, R1 is a hydrogen atom or an alkyl or alkoxy radical of 1-6 carbon atoms with the proviso that R1 is a hydrogen atom when X2 is other than a hydrogen atom, or an acid addition salt thereof. The molar ratio of a) to b) is preferably 1:1 to 1:3 and the pH of aqueous solutions of these compositions is preferably pH 9-10. Oxidising agents, e.g. hydrogen peroxide may also be used. Preferred compounds of formula I above are 6-amino-indoline dihydrochloride, 6-hydroxy-indoline hydrochloride, 1- ethyl-6-amino-indoline dihydrochloride and 1- ethyl-4-hydroxy-indoline hydrobromide.
The gold standard treatment for completely edentulous patients is a removable complete denture, which satisfies patients functional and aesthetic requirements at a low cost. However, the main problem associated with a complete denture is the instability of the complete removable denture, especially the mandibular one. Implant-assisted overdentures over two or three implants are used as a treatment option to increase stability, function, and retention of the denture at a reasonable cost. The immediate loading protocol allows the placement of temporary restoration on the day of implant placement surgery. Pierluigi Mondani pioneered intraoral welding in the early 1970s as an approach to load patients immediately with resin prosthesis and weld titanium implants to a titanium bar in their mouths. The technique of intraoral welding provides rigid splinting in cases of immediate implant loading. Occlusal loads and stability of occlusion are important to consider in the immediate loading of implants to avoid implant biomechanical failures, marginal bone loss, or even complete loss of osseointegration. Quantitative analyzers like t-scans, which are pressure-sensitive films, and virtual technology give a precise method of assessing the sequence of time and occlusal contact force magnitude by converting qualitative data into quantitative parameters. So, the current study protocol aims to compare the occlusion/ disocclusion time in immediately loaded implant retained overdentures supported by two interforaminal implants; splinted versus non splinted dental implants compared to the conventional complete denture.
<P>PROBLEM TO BE SOLVED: To provide a treatment method for enhancing a tumor-specific CTL in the body of tumor patient by using a tumor antigen protein or tumor antigen peptide as a so-called cancer immunotherapeutic drug (cancer vaccine) and a tumor antigen peptide having the activity.  <P>SOLUTION: The new tumor antigen protein having CTL induction activity is Papillomavirus binding factor: PBF registered as GenBank Accession No. AF263928. The CTL inducer comprises as an active ingredient a protein which comprises the same or substantially the same amino acid sequence as that of the amino acid. The tumor antigen peptide is derived from the protein.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Group of patients operated on during the year 2021 in San Juan de Dios Hospital for hip fracture and to which the new programme implementing functional recovery and therapeutic exercise will be applied with follow-up for one year. The implementation of a functional recovery plan and subsequent follow-up is considered a protective factor in relation to the loss of functionality.
Inflammation and oxidative stress are becoming more recognized as risk factors for ischemic stroke. Paeoniflorigenone (PA) has diverse pharmacological effects that include anti-inflammatory and antioxidant properties. However, the specific mechanisms by which PA affects cerebral ischemic stroke have not been studied. Our objective was to investigate the potential targets and mechanisms of PA in preventing cerebral ischemic stroke. We obtained the potential targets of PA from the SwissTargetPrediction, Super-PRED, and SEA Search Server databases. The GSE97537 dataset was utilized to identify gene targets related to ischemic stroke. The overlapping targets were imported into the STRING database to construct a protein-protein interaction network, and enrichment analyses were conducted using R software. Rats were pretreated with PA for three weeks before undergoing MCAO and reperfusion. H&E staining, ELISA, and qRT-PCR analyses were then performed to explore the potential mechanisms of PA. In the study, we identified 439 potential targets for PA and 1206 potential targets for ischemic stroke. Out of these, there were 71 common targets, which were found to be primarily associated with pathways related to oxidative stress and inflammation. The results from animal experiments showed that PA was able to improve nerve function and reduce inflammatory cytokines and oxidative stress in the MCAO-induced ischemic stroke model. Additionally, the expression of core genes in the MCAO + HPA group was significantly lower compared to the MCAO group. Our study revealed that the potential mechanisms by which PA prevents ischemic stroke involve oxidative stress and inflammation. These findings provide important theoretical guidance for the clinical use of PA in preventing and managing ischemic stroke.
BACKGROUND The relationship between different subgroups of type 2 diabetes (T2D) and the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis has not been thoroughly studied. This study aims to determine the association between T2D subgroups and the risk of developing advanced liver fibrosis using the Fibrosis-4 (FIB-4) index, a non-invasive marker for assessing liver fibrosis risk. MATERIAL AND METHODS A total of 1205 patients with T2D were categorized into 4 distinct subgroups: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD). The FIB-4 index was calculated for each patient to estimate the degree of liver fibrosis, with the following cutoff points: <1.3 indicating no or mild fibrosis, 1.3-2.67 suggesting moderate fibrosis, and >2.67 indicating advanced fibrosis (F3-F4). Logistic regression was used to compare the odds of advanced fibrosis across these subgroups. RESULTS The SIRD subgroup exhibited significantly higher odds of advanced liver fibrosis (F3-F4), compared with the other subgroups, as indicated by elevated FIB-4 scores (P<0.05). In contrast, the SIDD and MOD subgroups had lower odds of advanced fibrosis, while the MARD subgroup showed an intermediate association. CONCLUSIONS The findings suggest that the FIB-4 index, as a noninvasive assessment tool, effectively stratifies liver fibrosis risk among different T2D subgroups. This stratification can inform more personalized management strategies for patients with MASLD, underscoring the importance of accounting for the heterogeneity within T2D in clinical assessments of liver fibrosis risk.