anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Uvulopalatopharyngoplasty is one of the common procedures performed by otolaryngologists to treat sleep-disordered breathing patients who have retropalatal obstruction. Intraoperative bleeding is a significant problem which requires hemostasis and causes prolonged operative time. Several different techniques are used to perform this operation, including cold knife, monopolar cautery, coblation, and radiofrequency. Efficacy in hemostasis and tissue trauma from different operative techniques may result in different operative time and different degrees of morbidity including intraoperative blood loss, postoperative pain, postoperative hemorrhage, and velopharyngeal insufficiency (VPI). The vessel sealing system has been widely used in head and neck surgery because of its effectiveness and safety. It was also found quite effective and safe in tonsillectomy procedures, providing excellent hemostasis and minimal tissue trauma.
Subjects were randomly assigned to apply topical placebo to either the proximal or distal end of their incision every 48 hours for 4 weeks following surgical scar excision (14-16 treatments). The subject served as their own control.
A sustained release composition containing Nifedipine (I) is new. (I) is co-precipitated in-situ with polyvinylpyrrolidone and the precipitate is embedded in a mixture of a water soluble excipient (e.g. lactose) and a hydrophilic matrix forming polymer (e.g. hydroxypropylmethylcellulose). The composition provides a prolonged and nearly constant rate of drug absorption for \- 24 hours. The ratio of Nifedipine to polyvinylpyrrolidone is preferably 1:1 to 1:3. The ratio of Nifedipine to lactose is preferably 1:3 to 1:10 and the ratio of Nifedipine to hydroxypropylmethylcellulose is preferably 1:0.5 to 1:3. The average molecular weight of the polyvinylpyrrolidone is 40000 and various grades of hydroxypropylcellulose may be used ranging from 4000-100000 cps. The lactose may be replaced by other inert excipients e.g. mannitol, sorbitol, sucrose or glucose. The hydroxypropylcellulose may be replaced by hydroxyethylcellulose or methylcellulose.
H002 20mg QD, orally administered in fasting state, receive a single dose of H002 orally, followed by a 4-day washout period. Then, the same dose of H002 will be administered QD until disease progression or not tolerated.
INTRODUCTION: Multisectoral action is a central component of the global response to the rising prevalence of non-communicable diseases (NCDs). In this paper we aimed to unpack the definition of multisectoral action and provide an overview of the historical context, challenges, and recommendations alongside three country case studies: salt reduction in the UK, tobacco legislation in Nigeria, and regulation of edible oils in Iran.
METHODS: We used an iterative review process to select three country case studies from a list of 20 potential cases previously identified by WHO. At our third round of review we unanimously agreed to focus on salt reduction in the UK, tobacco regulation in Nigeria, and edible oil regulation in Iran as these represented rich cases on diverse risk factors from three different world regions that we felt offered important lessons. We conducted literature reviews to identify further data for each case study.
RESULTS: Across the three studies a number of important themes emerged. We found that multisectoral approaches demand the often difficult reconciliation of competing and conflicting values and priorities. Across our three chosen cases, commercial interests and free trade agreements were the most common obstacles to successful multisectoral strategies. We found that early consultative stakeholder engagement and strong political and bureaucratic leadership were necessary for success.
DISCUSSION: The complex multi-rooted nature of NCDs requires a multisectoral approach, but the inevitable conflicts that this entails requires careful navigation.
Subjects in this arm will receive placebo 3 times daily for 28 days. Placebo will consist of 23.7g of excipient-matched placebo in water. Participants will also undergo single-leg immobilization (Breg brace) for 7 days (days 8-15) during the 28 day study period.
The present invention relates to medicine for treating rhinitis, which belongs to a Chinese medicine preparation for internal use. The present invention mainly solves the problems of long treating courses for treating rhinitis and easy recurrence. The medicine is prepared by the following Chinese medicine raw materials of 9 g of cassia twigs, 8 g of radix paeoniae alba, 5 g of prepared licorice, 5 g of cicada ecdysis, 8 g of xanthium, 8 g of cogongrass rhizome, 3 g of lepidium seeds, 2 g of ginger and 3 g of Chinese dates. The medicine is decocted with water, and a person takes one agent every day, and separately takes the medicine in the morning and at night. The present invention treats rhinitis for more or less than 10 days, and the rhinitis symptoms are obviously improved. The rhinitis can be cured for more or less 30 days, and the curative effect is obvious. 200 persons are clinically tracked, and persons who do not recur within 2 years account for 85% of the 200 persons. The present invention is suitable for various kinds of rhinitis.
No data are available with regard to overdosage with dutasteride and tamsulosin hydrochloride capsules. The following text reflects information available for the individual components.

Dutasteride

In volunteer trials, single doses of dutasteride up to 40 mg (80 times the therapeutic dose) for 7 days have been administered without significant safety concerns. In a clinical trial, daily doses of 5 mg (10 times the therapeutic dose) were administered to 60 subjects for 6 months with no additional adverse effects to those seen at therapeutic doses of 0.5 mg.

There is no specific antidote for dutasteride. Therefore, in cases of suspected overdosage symptomatic and supportive treatment should be given as appropriate, taking the long half-life of dutasteride into consideration.

Tamsulosin

Should overdosage of tamsulosin lead to hypotension [see Warnings and Precautions (5.1), Adverse Reactions (6.1)], support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then administration of intravenous fluids should be considered. If necessary, vasopressors should then be used and renal function should be monitored and supported as needed. Laboratory data indicate that tamsulosin is 94% to 99% protein bound; therefore, dialysis is unlikely to be of benefit.
AIM: The primary objective of this study is to determine the impact of a standardised feeding protocol for infants with gastroschisis on early enteral feeds, suck feeds, management of gastric residuals and breastfeeding at discharge. Secondary objectives were evaluation of growth, length of stay in neonatal intensive care unit (NICU), the duration of total parental nutrition (TPN), blood-culture confirmed sepsis and serum bilirubin level (SBR).
METHODS: This single-centre retrospective quality improvement project included infants admitted to a quaternary care NICU for management of gastroschisis from 2010 to 2021. The Gastroschisis feeding protocol, a standardised pathway for managing the feeding of infants with gastroschisis, was implemented in this NICU in 2016. The outcomes of infants in the pre-feeding protocol and post-feeding protocol groups were compared.
RESULTS: Of the 100 infants included in the study, 49 were in the post-feeding protocol group. The baseline characteristics of the study population did not differ statistically in both groups. In post-feeding protocol group, there was significant reduction in the time to the first enteral feed (P value <0.0001) and first suck feed (P value = 0.002). The median length of stay in the post-feeding protocol group was significantly lower by 11 days (P value = 0.001). Duration of TPN was 241 h higher in the pre-feeding protocol group (P value 0.0007).
CONCLUSIONS: Implementation of a feeding protocol in infants with gastroschisis led to earlier initiation of enteral feeds and suck feeds. There is a likelihood of reduction in the use of TPN and duration of admission in NICU.
Background and Objectives: Postoperative shoulder pain is a common issue after total laparoscopic hysterectomy (TLH). This study evaluated the impact of a shoulder movement routine on postoperative shoulder pain in women undergoing uncomplicated TLH. Materials and Methods: An open-label randomized clinical trial included women without prior shoulder pain undergoing TLH between 20 January and 20 March 2024. Participants were randomized into two groups: Group 1 (n = 36) received a shoulder movement routine, while Group 2 (control, n = 39) performed a hand movement routine. Shoulder pain was assessed using the visual analog scale (VAS) at 6 h, 24 h, and 7 days postoperatively. Results: Seventy-five women participated. No significant differences were found between the groups regarding demographic variables, surgery duration, or hospital stay. Shoulder pain scores (VAS) at three time points (6 h, 24 h, and 7 days) showed no significant differences between groups (p = 0.57, p = 0.69, and p = 0.91, respectively). Similarly, there were no significant differences in incisional or abdominal pain. Conclusions: The shoulder movement routine did not significantly reduce postoperative shoulder pain in women undergoing uncomplicated TLH.
Alcohol use disorder (AUD) is strongly linked with deficits in alcohol-free alternative rewards. Individuals with AUD have limited sources of substance-free (SF) natural rewards. Increasing SF rewards in the context of treatment is of immediate public health relevance as it has the potential to improve AUD treatment outcomes. Yet, this is not a focus of standard outpatient treatment. Prior studies demonstrate that interventions focused on SF alternatives in addition to standard treatment improve outcomes above and beyond standard treatment alone. However, these efficacious treatments can be difficult to implement and sustain within a real-world AUD treatment facility. Therefore, it is essential to enhance the approach used in these studies to meet the needs of patients and treatment facilities alike. Novel methodologies that are cost effective, technologically enhanced, and less time intensive are needed to better incorporate this intervention within a treatment setting. The proposed study would make use of mobile technology to aid patients engage in alternative behaviors, who otherwise may have limited access to activities other than drinking, and thereby potentially help reduce risk of relapse.

This research proposal aims to develop and evaluate an ecological momentary intervention (EMI) supported by an ecological momentary assessment (EMA) aimed at increasing reinforcement from substance-free activities among AUD patients in order to improve treatment outcomes. Towards this end, this research will be conducted in two phases. Phase 1 will entail an iterative process of EMA plus EMI development of a smartphone app, called mobile-Rewarding Activity Centered Treatment (m-ReACT), designed to collect real-time data on substance-free activity engagement and obtained reward. The data will then be provided back to the individuals to encourage engagement in activities that were most rewarding.

Upon app successful app development, this study will implement phase 2. Phase 2 will consist of a pilot RCT (N=50) to evaluate m-ReACT as an adjunctive intervention for AUD treatment-seekers compared to a brief advice (BA) session on engaging in SF pleasant activities. Participants will be randomized to either an in-person informational session consisting of BA on the importance of engaging in SF rewarding activities or brief in-person app orientation session that will collect daily reporting of substance free activity engagement and enjoyment and provide personalized feedback on level of substance free activity engagement and enjoyment with encouragement to continue engagement. Feasibility and acceptability of m-ReACT will be assessed with self-report measures, qualitative end-of treatment interviews, and examination of app usage from the app metadata. Follow-up assessments will be conducted at 3 (end of treatment) and 6-months to evaluate for drinking related outcomes and SF reinforcement.
The present invention relates to a composition composed of nicotinic acid or a derivative thereof and rosuvastatin, and the composition is used for treating hyperlipoidemia. The composition contains an effective quantity of active components as follows: the nicotinic acid or the derivative thereof and the rosuvastatin; the derivative of the nicotinic acid is inositol nicotinate, vitamin E nicotinate or acipimox. Compared with single application of the effective quantity of active components (1) or active components (2) to treat patients suffering from the hyperlipemia. The composition comprising the active component (1) and the active component (2) gives surprising effect. The present invention has the advantages of large selectable medicine consumption range, long duration time of therapeutic effect, good comprehensive effect and convenient use. Results obtained from pharmacology tests distinctly indicate that the composition composed of the rosuvastatin and acipimox or the rosuvastatin and the nicotinic acid can effectively reduce the blood fat.
Nascent oxygen is used for cosmetological treatment and is produced (a) in an aqs. soln. of immediate use, specifically for dyeing hair, pref. by reacting an NACL soln. with H2O2 and for facial treatment by foaming the soln. contg. the nascent oxygen with soap, (b) by passing oxygen through a micro-wave generator or (c) by excitation of oxygen with UV rays. Nascent oxygen is biologically neutral and is less harmful than ordinary oxygen towards living tissues. Other uses include bath prepns., prepn. of beauty masks and in facial sprays as a replacement for ozone.
To evaluate the effects of a community-based counseling intervention to improve contraception among residents in deprived neighborhoods a randomized controlled trial is performed. Women aged 14-49 years and men aged 14-39 years from two low income neighborhoods in Barcelona (Catalonia, Spain) who had not undergone an irreversible contraceptive method and aren't planning a pregnancy have been recruited in 2011-13. The intervention consists of a culturally developed and theoretically-based brief counseling in community settings. The primary outcome is the consistent use of very effective contraceptive methods (optimal use). Secondary outcomes analyzed are the incorrect use of very effective contraceptive methods and use of less effective methods stratified by sex and migrant status. Differences within subgroups from baseline to 3 months - follow up are analyzed and intervention effects are assessed with adjusted robust Poisson regressions.
PROBLEM TO BE SOLVED: To obtain an inhibitor of the cytokine production for ocular stopical use effective in preventing and treating various eye diseases such as uveitis by formulating a specific amide compound as an active ingredient therein. SOLUTION: This inhibitor of the cytokine production for ocular topical use contains an amide compound represented by the formula as an active ingredient. The inhibitor is especially an inhibitor of the production of a tumor necrosis factor-α (TNF-α). Furthermore, the inhibitor is preferably used in the form of an eye drop, especially the form of an aqueous suspension eye drop. The inhibitor preferably contains the amide compound represented by the formula at 0.01-10 (wt./vol.)%, especially 0.1-3 (wt./vol.)% concentration. The dose of the inhibitor is preferably 1-3 drops instilled and administered at a time twice to six times a day when used as the eye drop for, e.g. an adult.
A method for performing a medical procedure includes holding a non-linear dependence between the duration of a given phase within a cardiac cycle and a respective heartbeat rate. First and second image sequences of the dynamic activity of the heart of a patient, acquired at respective different first and second heartbeat rates of the heart, are received. Synchronization between the first and second image sequences is performed based on the non-linear dependence, on the first and second heartbeat rates, and on a given common heartbeat rate. The first and second image sequences are played in synchronization with the common heartbeat rate. 06/07/15 27??RR -n-i 26 24 22 48 44 42 z34 -38
Hepatocellular carcinoma (HCC) is a common malignancy worldwide, with the number of new cases and deaths increasing yearly. Curative surgery continues to be the preferred treatment for early-stage HCC. However, some early-stage HCC often experience early recurrence after surgery, and one of the most common risk factors is microvascular invasion (MVI). Nevertheless, the overall prognosis of some MVI-negative patients is also not satisfactory. Whether there are other hidden robust risk factors for recurrence is of intense interest to clinical scientists.

In contrast to the classic capillary pattern, cobweb-like pattern of vascular is present in renal cell carcinoma, thyroid follicular carcinoma and HCC. Specifically, this particular vascular pattern is a continuous lining of sinusoid-like vessels that isolate and encapsulate individual tumor clusters, and Fang et al. named it vessels that encapsulate tumor clusters (VETC). CD34 or CD31 immunohistochemical staining of tumor tissue can easily identify the vascular pattern of VETC, which can exist at any stage of HCC, accounting for about 40%-50.6%. VETC could directly invade adjacent vascular and migrate as tumor clusters instead of epithelial-mesenchymal transition pathway, which may well explain why VETC-positive HCC is closely associated with higher postoperative recurrence rate and poor prognosis. Due to the high proportion of VETC vascular patterns and poor prognosis, it is necessary to adopt effective adjuvant treatment. Zhuan et al found that unresectable VETC+HCC could benefit from treatment with sorafenib in a subsequent study. Similarly, another study found that FGF 2 and FGFR 3-4 (rather than VEGF-A or VEGFR 1-3) were high expression in VETC+ HCC, which raise the possibility that lenvatinib is a potentially effective treatment modality. Recently, a multicenter randomized controlled trial of postoperative adjuvant Sintilimab reported encouraging positive results, suggesting the possibility of its application in VETC-positive patients. Whether the combination of lenvatinib and Sintilimab can further improve the prognosis is also worth exploring.

To address these clinical challenges, the investigators conducted a multicenter study involving three surgical cohorts with postoperative active surveillance cohort(AC), adjuvant Sintilimab cohort(AS), and adjuvant Sintilimab plus Lenvatinib cohort(ASL). The cases in the AS cohort were mainly from a previous prospective cohort study initiated by the investigator's center and a later cohort expansion (NCT05307926). Moreover, multi-omics sequencing analysis aims to further explore the molecular biological characteristics between VETC positive and negative HCC.
PROBLEM TO BE SOLVED: To obtain a nature-derived oral antibacterial agent having excellent antibacterial action on intraoral bacteria causing caries.periodontal disease and widely applicable to various foods and drinks and oral products by effectively utilizing an extract of seeds or leaves of Perilla frutescens crispa or Perilla ocimoides. SOLUTION: This oral antibacterial agent contains seeds or leaves of Perilla frutescens crispa or Perilla ocimoides as an active component. An alcohol extract of seeds or leaves of Perilla frutescens crispa or Perilla ocimoides is divided to ethyl acetate fraction and water-soluble fraction and the ethyl acetate fraction as the ethyl acetate layer may be used as the active component. As the seeds of Perilla frutescens crispa or Perilla ocimoides, defatted seeds of Perilla frutescens crispa or Perilla ocimoides may be used. The oral antibacterial agent contains luteolin, rosemarinus acid or their derivatives as active components. The foods and drinks or oral products contain this oral antibacterial agent.
Intensive F.O.T.T.® intervention was given twice a day, approximately 20 minutes per intervention, exclusive time to position the patient. Before and after the intervention, the patient was positioned in a standardized way in side lying for 10 minutes to rest. Here, the Electromyographic Bioimpedance Measuring device (EMBI) measured the spontaneous swallowing frequency and -quality during both, the resting period and the intervention. In the intervention itself, the patient was facilitated with specific handling and interventions to swallow, according to F.O.T.T.®. The faciltation was embedded into a meaningful context for the patient, e.g. tooth brushing or eating small amounts of apple sauce, if safe.
Using prefecture-level policy documents (2008-2018) and the China Health and Retirement Longitudinal Study (2011-2018), this study used fixed-effects regressions to examine the associations between the maturity of two age-friendly policies, i.e., old age care (OAC) and preferential treatment (PT) policies for older adults, and the self-rated health (SRH) of older adults. We use policy duration and policy density to measure policy maturity. The results showed positive relationships exist between the density of OAC and PT policy and older adults' SRH, whereas long policy duration often relates to lower SRH. Policy duration and policy density work synergistically. Furthermore, heterogeneity analyses indicated that older adults aged over 75 years, male, those with physical or mental impairment, and living in rural areas and in the first- and second-tier cities benefit significantly from denser OAC policy. The SRH of older adults suffering from physical disabilities or mental problems and living in rural areas is positively associated with denser PT policy. From a policy perspective, our findings suggest that age-friendly policies should be updated over time and be place- and characteristic-tailored.
FIELD: organic chemistry. SUBSTANCE: method involves synthesis of pure isoflavone derivatives of the formula (I) given in description where R - hydrogen or isopropyl; R 2   and R 3  - hydrogen or C 1 -C 2 -alkoxy-group. Synthesis is carried out by cyclization of resorcinol derivative of the formula (II) given in description with ethyl-ortho-formate at 70-100 C (preferably at 80-90 C) in the presence of organic solvent (preferably in dimethylformamide and/or isopropanol) at 0.3-2-fold quantity with respect to measured volume of resorcinol derivatives of the formula (III) given in description, and/or in the presence of ethyl-ortho-formate excess for preparing 20-70% supersaturated solution of product of the formula (III). The latter is isolated continuously from the mixture following by cooling of reaction mixture and separation of compound of the formula (II) by filtration where R 1  - hydrogen; R 2   and R 3  - see above, and/or by addition of nonpolar or polar solvent to reaction mixture with selective dissolving of formed by-side product of the formula (V) given in description where R 1  - hydrogen; R 2  and R 3  - see above, and/or addition of almost equivalent quantity of anhydrous potassium carbonate to reaction mixture and isolation of crystallized out double salt of the formula (IV) given in description where R 2   and R 3  - see above. Then compound of the formula (IV) or (I) where R 1  - hydrogen is alkylated with haloidalkyl, and the end pure product of the formula (I) is isolated where R 1  - isopropyl and containing not more 0.5% polluting impurity of compound of the formula (V). Double salt is formed after addition of nonpolar solvent (preferable toluene) and anhydrous potassium carbonate at 40-80 C (preferably at 60 C). Ethanol formed in cyclization reaction is remained in reaction medium. Purity of the end product is above 99.8% . Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 4 cl