anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND AIMS: Steatotic liver disease (SLD) is generally considered to represent a hepatic manifestation of metabolic syndrome and includes a disease spectrum comprising isolated steatosis, metabolic dysfunction-associated steatohepatitis, liver fibrosis and ultimately cirrhosis. A better understanding of the detailed underlying pathogenic mechanisms of this transition is crucial for the design of new and efficient therapeutic interventions. Thymocyte differentiation antigen (Thy-1, also known as CD90) expression on fibroblasts controls central functions relevant to fibrogenesis, including proliferation, apoptosis, cytokine responsiveness, and myofibroblast differentiation.
METHODS: The impact of Thy-1 on the development of SLD and progression to fibrosis was investigated in high-fat diet (HFD)-induced SLD wild-type and Thy-1-deficient mice. In addition, the serum soluble Thy-1 (sThy-1) concentration was analysed in patients with metabolic dysfunction-associated SLD stratified according to steatosis, inflammation, or liver fibrosis using noninvasive markers.
RESULTS: We demonstrated that Thy-1 attenuates the development of fatty liver and the expression of profibrogenic genes in the livers of HFD-induced SLD mice. Mechanistically, Thy-1 directly inhibits the profibrotic activation of nonparenchymal liver cells. In addition, Thy-1 prevents palmitic acid-mediated amplification of the inflammatory response of myeloid cells, which might indirectly contribute to the pronounced development of liver fibrosis in Thy-1-deficient mice. Serum analysis of patients with metabolically associated steatotic liver disease syndrome revealed that sThy-1 expression is correlated with liver fibrosis status, as assessed by liver stiffness, the Fib4 score, and the NAFLD fibrosis score.
CONCLUSION: Our data strongly suggest that Thy-1 may function as a fibrosis-protective factor in mouse and human SLD.
Those 18 years of age and older, diagnosed with a stroke, spinal cord injury (traumatic and non-traumatic), or acquired brain injury (of all severities, including concussion) living in the community will be included. Additionally, only those the cognitive capacity to understand and complete the measures will be included. Those who consent will complete an online survey on enrollment into the study, and subsequently at 3 and 6 months.
Patients with anaplastic thyroid cancer (ATC) receive 800 mg pazopanib hydrochloride PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
OBJECTIVE: Education often reflects socioeconomic status. Research indicates that lower socioeconomic status may increase the risk of diverticulosis, and according to data from the USA, diverticular disease is a significant and costly health problem. Our study explores the link between educational level and colonic diverticula occurrence.
SUBJECT AND METHODS: We conducted a cohort study on 5,532 asymptomatic Austrian patients who underwent colonoscopy, categorizing them by education level using the updated Generalized International Standard Classification of Education (GISCED). Logistic regression models, adjusting for age, gender, metabolic syndrome, diet, and activity, were used to determine the association between education and diverticulosis.
RESULTS: Overall, 39% of the patients had low educational status, while 53% had medium, and 8% had high educational status. Colon diverticula were less frequent in patients with medium (OR 0.73) and high (aOR 0.62) educational status. Medium educational level remained associated with lower rates of diverticulosis after adjustment for age and sex (aOR 0.85) and further metabolic syndrome, dietary habits, and physical activity (aOR 0.84). In higher education status, this phenomenon was only seen by trend.
CONCLUSION: Low education correlated with higher colon diverticula risk, while medium education showed lower rates even after adjustments. This trend persisted at higher education levels, highlighting the potential for strategies for cost reduction tailored to socioeconomic conditions.
Macrophage migration inhibitory factor (MIF) is an innate cytokine that regulates both inflammatory and homeostatic responses. MIF is expressed by cardiomyocytes, where it exerts a protective action against ischemia-reperfusion (I/R) injury by activating AMP-activated protein kinase (AMPK). This effect is attenuated in the senescent heart due to an intrinsic, age-related reduction in MIF expression. We hypothesized that treating the aged heart with the small molecule MIF agonist (MIF20) can reinforce protective MIF signaling in cardiomyocytes, leading to a beneficial effect against I/R stress. The administration of MIF20 at the onset of reperfusion was found to not only decrease myocardial infarct size but also preserves systolic function in the aged heart. Protection from I/R injury was reduced in mice with cardiomyocyte-specific Mif deletion, consistent with the mechanism of action of MIF20 to allosterically increase MIF affinity for its cognate receptor CD74. We further found MIF20 to contribute to the maintenance of mitochondrial fitness and to preserve the contractile properties of aged cardiomyocytes under hypoxia/reoxygenation. MIF20 augments protective metabolic responses by reducing the NADH/NAD ratio, leading to a decrease in the accumulation of reactive oxygen species (ROS) in the aged myocardium under I/R stress. We also identify alterations in the expression levels of the downstream effectors PDK4 and LCAD, which participate in the remodeling of the cardiac metabolic profile. Data from this study demonstrates that pharmacologic augmentation of MIF signaling provides beneficial homeostatic actions on senescent myocardium under I/R stress.
The invention discloses a Yao medicine preparation for treating acquired immune deficiency syndrome and a preparation method of the Yao medicine preparation. The Yao medicine preparation is composed of an oral preparation and an external washing preparation. The oral preparation comprises the following raw materials in parts by weight: 10-30 parts of longleaf dandelion, 10-30 parts of sophora flower, 10-30 parts of glycyrrhiza uralensis, 10-30 parts of silvervine, 10-30 parts of Cyathea spinulosa stem, 10-30 parts of ardisia japonica blume, 10-30 parts of Mussaenda philippica and 10-30 parts of giant knot weed. The external washing preparation comprises the following raw materials in parts by weight: 20-40 parts of perforate fleeceflower, 20-40 parts of evodia lepta, 20-40 parts of radix sophorae flavescentis, 20-40 parts of entada phaseoloides, 20-40 parts of senecio, 20-40 parts of bayberry bark, 20-40 parts of ninebark, 20-40 parts of silvervine, 20-40 parts of golden cypress skin and 20-40 parts of rhus chinensis. The therapeutic suitable for most infected people of Guangxi is prepared according to traditional Chinese medicine clinical characteristics of Guangxi acquired immune deficiency syndrome and clinical technology solutions for treating of acquired immune deficiency syndrome with traditional Chinese medicine (trial implementation) constituted by State Chinese Medicine Administration Bureau and combining factors of climatic characteristics, environmental factors, personnel conditions, physical characteristics and the like of Guangxi. By utilizing the Yao medicine preparation, symptoms of patients can be relieved, diffusion of human immunodeficiency virus can be restrained, and immunity can be enhanced. The Yao medicine preparation does not have side effects.
Berotralstat administered once daily in 4 dose cohorts determined by participant weight. Cohorts 1 and 2 will enroll in parallel. After 4 participants from Cohort 1 and 2, with ≥ 2 subjects from Cohort 2, have reached Week 2, Cohort 3 will open for enrollment. Cohort 4 will open for enrollment, after ≥ 4 subjects in Cohort 3 have reached Week 2. Prior to dosing Cohort 3 and 4, available PK and safety data will be reviewed to confirm it is safe to proceed and the appropriate weight bands for each. BioCryst will notify sites when Cohorts 3 and 4 are open for enrollment.
This study will aim to explore the effectiveness of a stress management program in nursing professionals in a community teaching hospital in Nepal. A 4-day stress management training program will be conducted and pre and post-training stress levels will be measured using the Perceived Stress Scale (PSS) and the Stress-Subscale of the Depression, Anxiety and Stress Scale-21 (DASS-21) one week prior to and after the training program. This experimental pre-post double arm study will involve 86 participants - all nursing staff from the Dhulikhel Hospital. Participants will be divided into 2 groups - treatment and control. The treatment group will be further divided into 2 groups of 20-25. The stress management training program will be held across 4 weeks with both groups receiving one training course each week (eg. Week 1 - session 1; Week 2 - session 2). Both questionnaires will be distributed again to both groups, 1 month after the last stress management session (1 - month follow up) .The control group whilst not being subjected to the Stress management training during the study period, will obtain the training upon study completion.
A double-blind study enrolled 1111 febrile, neutropenic (<500 cells/mm3) patients who were randomized to treatment with daily doses of CANCIDAS (50 mg/day following a 70-mg loading dose on Day 1) or AmBisome (3 mg/kg/day). Patients were stratified based on risk category (high-risk patients had undergone allogeneic stem cell transplantation or had relapsed acute leukemia) and on receipt of prior antifungal prophylaxis. Twenty-four percent of patients were high risk and 56% had received prior antifungal prophylaxis. Patients who remained febrile or clinically deteriorated following 5 days of therapy could receive 70 mg/day of CANCIDAS or 5 mg/kg/day of AmBisome. Treatment was continued to resolution of neutropenia (but not beyond 28 days unless a fungal infection was documented).

An overall favorable response required meeting each of the following criteria: no documented breakthrough fungal infections up to 7 days after completion of treatment, survival for 7 days after completion of study therapy, no discontinuation of the study drug because of drug-related toxicity or lack of efficacy, resolution of fever during the period of neutropenia, and successful treatment of any documented baseline fungal infection.

Based on the composite response rates, CANCIDAS was as effective as AmBisome in empirical therapy of persistent febrile neutropenia (see Table 9).

The rate of successful treatment of documented baseline infections, a component of the primary endpoint, was not statistically different between treatment groups.

The response rates did not differ between treatment groups based on either of the stratification variables: risk category or prior antifungal prophylaxis.
BACKGROUND: Marijuana potency and utilization both continue to increase across the United States. While the overall prevalence of cannabinoid utilization during pregnancy has been surveyed in various studies, the direct impact of changing governmental policies on pregnancy use is less characterized. Thus, we aimed to investigate how the legalization of recreational cannabinoid products impacted use during pregnancy in the state of New Mexico.
METHODS: Participants who had a live birth during two study epochs were included: pre-legalization (Epoch 1: 1 January 2019-31 March 2021) and post-legalization (Epoch 2: 1 November 2021-30 November 2022). Participants were further divided into case group [prenatal cannabinoid exposure (PCE)] vs. control (no PCE), with cases being identified by documented self-report or a positive laboratory toxicology test for cannabinoid use during pregnancy.
RESULTS: A total of 1,191 maternal/infant dyads were included in Epoch 1, and 378 maternal/infant dyads were included in Epoch 2. In Epoch 1, 788 dyads were controls with 403 cases, while Epoch 2 had 292 controls and 86 cases. Interestingly there was a significant decrease in self-report or positive laboratory toxicology tests in Epoch 2 compared to Epoch 1. Infants born following PCE in both Epoch groups were more commonly born via Cesarean section, had significantly smaller birth weight, length, and head circumference as well as significantly lower Apgar scores at 1 and 5 min.
CONCLUSION: The finding of decreased reported cannabinoid use in the post-legalization group is contradictory to previous studies which have shown increased rates of cannabinoid use after legalization. This could be due to multiple factors including changes in screening practices, the COVID-19 pandemic, and lack of commercialization of THC products. Additional studies are needed to further characterize how changing governmental policies impacts utilization during pregnancy.
Each participant will be provided with an informed consent form detailing the purpose of the study. After obtaining written consent, baseline data will be collected, including demographic information, medical history, and any pre-existing conditions. The participants will then undergo the post-laparotomy interventions as described. Throughout the intervention period, data will be collected using the tools mentioned: 6 minute Walk Test, 5 Times Sit to Stand test, 2 Minute walk Test, and Timed Up and GO to determine any changes in their functionality and overall well-being on post operative day 1 and before discharge. For reliability, tests will be conducted twice a day with a minimum gap of 2 hours, both on day 1 and on the day of discharge.
Stevens-Johnson syndrome (SJS) is a severe adverse drug reaction affecting the skin and mucosal membranes, characterised by lesions covering less than 10% of the body's surface. Although gastrointestinal (GI) complications are usually mild, severe GI involvement can be life-threatening. A woman in her 30s with end-stage renal disease developed sepsis from methicillin-sensitive Staphylococcus aureus After 15 days of hospitalisation and antibiotic treatment, she developed new skin lesions, followed by massive GI bleeding and haemodynamic instability. Oesophagogastroduodenoscopy revealed necrotic plaques and mucosal sloughing along the oesophagus. Skin biopsy results confirmed SJS. Despite intensive care and multiple blood transfusions, she required intravenous dexamethasone. The patient improved and was discharged after 6 weeks. SJS can lead to serious complications, including rare but potentially life-threatening GI involvement. Effective management involves drug withdrawal, intensive care, immunosuppression and symptomatic treatment.
The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and damage that can disrupt corneal epithelium and nerves, triggering inflammation. Therefore, understanding the biological effects and molecular mechanisms involved in corneal wound healing and identifying drugs targeting these pathways is crucial for researchers in this field. This study aimed to investigate the therapeutic potential of progranulin (PGRN) in treating corneal injuries. Our findings demonstrated that PGRN significantly enhanced corneal wound repair by accelerating corneal re-epithelialization and re-innervation. In vitro experiments with cultured epithelial cells and trigeminal ganglion cells further revealed that PGRN stimulated corneal epithelial cell proliferation and promoted axon growth in trigeminal ganglion cells. Through RNA-sequencing (RNA-seq) analysis and other experimental techniques, we discovered that PGRN exerted its healing effects modulating Wnt signaling pathway, which played a critical role in repairing epithelial cells and promoting axon regeneration in trigeminal neurons. Importantly, our study highlighted the anti-inflammatory properties of PGRN by inhibiting the NF-κB signaling pathway, leading to decreased infiltration of macrophages. In conclusion, our findings underscored the potential of PGRN in facilitating corneal wound healing by promoting corneal epithelial cell proliferation, trigeminal ganglion cell axon regeneration, and suppressing ocular inflammation. These results suggest that PGRN could potentially expedite the healing process and improve visual outcomes in patients with corneal injuries.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivatives of quinuclidine of the formula (I) where ring A means phenyl group that can be optionally substituted with halogen atom or lower alkyl group, cyclohexyl, pyridyl, furyl or thienyl group; X mean a single bond or methylene group; I means 0 or 1; n means a whole number 1 or 2 or their salts with acids or their quaternary ammonium salts. Invention describes also pharmaceutical compositions based on thereof. These compounds show an antagonistic effect with respect to muscarinic M 3 -receptors and useful as prophylactic or curative agents in patients with urological, respiratory or digestion system diseases. EFFECT: enhanced effectiveness of new compounds indicated above. 5 cl, 33 tbl, 19 ex
BACKGROUND: Cardiovascular disease is the leading cause of death among patients with Duchenne muscular dystrophy (DMD). Identifying patients at risk of early death could allow for increased monitoring and more intensive therapy. Measures that associate with death could serve as surrogate outcomes in clinical trials.
METHODS AND RESULTS: Duchenne muscular dystrophy subjects prospectively enrolled in observational studies were included. Models using generalized least squares were used to assess the difference of cardiac magnetic resonance measurements between deceased and alive subjects. A total of 63 participants underwent multiple cardiac magnetic resonance imaging and were included in the analyses. Twelve subjects (19.1%) died over a median follow-up of 5 years (interquartile range, 3.1-7.0). Rate of decline in left ventricular ejection fraction was faster in deceased than alive subjects (P<0.0001). Rate of increase in indexed left ventricular end-diastolic (P=0.0132) and systolic (P<0.0001) volumes were higher in deceased subjects. Faster worsening in midcircumferential strain was seen in deceased subjects (P=0.049) while no difference in global circumferential strain was seen. The rate of increase in late gadolinium enhancement, base T1, and mid T1 did not differ between groups.
CONCLUSIONS: Duchenne muscular dystrophy death is associated with the rate of change in left ventricular ejection fraction, midcircumferential strain, and ventricular volumes. Aggressive medical therapy to decrease the rate of progression may improve the mortality rate in this population. A decrease in the rate of progression may serve as a valid surrogate outcome for therapeutic trials.
In this study, we aimed to investigate the molecular mechanism of Krüppel-like factor 7 (KLF7) in colorectal cancer (CRC) cell invasion and migration. The expression pattern of KLF7 in CRC tissues and the correlation between KLF7 expression and clinical symptoms of CRC were analyzed. CRC cell lines were transfected with si-KLF7, followed by qRT-PCR or western blot detection of KLF7, miR-139-5p, and tumor protein D52 (TPD52) expression, cell counting kit-8 (CCK-8) assay to detect cell viability, and transwell detection of invasion and migration. Chromatin immunoprecipitation (ChIP) analyzed the enrichment KLF7 in the miR-139-5p promoter. The dual-luciferase reporter assay verified the binding relationship between KLF7 and miR-139-5p, and between miR-139-5p and TPD52. In the subcutaneous tumorigenesis experiment, tumor growth was observed and ki67-positive expression was detected. KLF7 is abundantly expressed in CRC cells KLF7 silencing inhibits CRC cell viability, invasion, and migration. KLF7 represses miR-139-5p expression by binding to the miR-139-5p promoter. miR-139-5p targets TPD52 expression. miR-13-5p inhibition or TPD52 overexpression partially counteracted the effect of KLF7 silencing in CRC cells. KLF7 silencing suppresses tumor growth in vivo. In conclusion, KLF7 suppresses miR-139-5p expression by binding to the miR-139-5p promoter, thereby upregulating TPD52 expression and enhancing CRC cell invasion and migration.
The invention discloses a traditional Chinese medicine preparation for treating knee osteoarthritis. Kidney-yang deficiency and spleen and kidney yang deficiency are the main pathogenesis of knee osteoarthritis. Knee osteoarthritis is mostly caused by deficiency of native endowment and acquired dystrophy or kidney and spleen qi deficiency caused by internal injury due to excessive fatigue and aeipathia and malnutrition and then spleen and kidney yang deficiency. The following traditional Chinese medicines with the functions of tonifying the liver and kidney, relaxing tendons and activating collaterals, promoting blood circulation to remove blood stasis and dispelling wind and eliminating dampness: hemerocallis citrina, white paeony root, root and stem of berchemia huana rehd, wrightia pubescens, radix gaultheriae, archiphysalis sinensis (Hemsl.) Kuang, blueberries, heterohairy monkshood root, dchisandra propingua var.sinensis and spilanthes callimorpha A.H.Moore are selected and are decocted into decoction with water. Through clinical tests, the traditional Chinese medicine preparation has obvious curative effects and does not have adverse effects.
FIELD: enzymology. SUBSTANCE: streptolyase is a preparation containing enzyme streptokinase isolated from hemolytic streptococcus C culture. Method involves streptolyase dissolving, addition of polymeric saccharide to solution, stirring and sterilizing filtration. Solvent: 2-6% glucose aqueous solutions. Polymeric polysaccharide: hyaluronic acid taken at amount 1-2 mg per 100000 U streptolyase. Also, ascorbic acid is added to solution at amount 20-30 mg per 100 ml. Streptolyase preparation is used in medicine. EFFECT: enhanced stability at storage.
FIELD: veterinary science, vaccines. SUBSTANCE: invention relates to preparing vaccine used for specific prophylaxis of mixed infectious diarrheas in newborn calves. Industrial strains of rota-, corona-, herpes viruses of cattle and E. coli synthesizing adhesive antigens K99, A20 are used as source of specific antigens. Strains are cultured separately. Rotaviruses are cultured in pig kidney transplanted culture cells (strain SPEV). Coronaviruses are cultured in cow embryo kidney transplanted culture cells (strain MDVK). Herpes viruses are cultured in cow embryo trachea transplanted culture cells (TR) in roller units of industrial type. E. coli cells synthesizing adhesive antigens K99, A20 are cultured on Mink's medium and beef-extract agar. Rota- and herpes viruses are collected in 24-48 h, coronaviruses - in 72-96 h and E. coli cells - in 24-36 h. Viruses are inactivated with 0.5-% formalin solution at 25-27 C for 24-36 h. E. coli culture is inactivated with 0.5-% formalin at 36-37 C for 72 h. Inactivated cultures are mixed. To obtained mixture 6-% solution of aluminium hydroxide gel is added at amount 10-%. For prophylaxis aim vaccine is administrated in deep-pregnant cows and heifers (30-35 days before calving) twice at break for 14-15 days at the dose 10 cm 3  by intramuscular route. Vaccine is able to elevate the level of accumulation of specific protective antibodies in vaccinated cows serum blood and colostrum and prevent calves death due to colostrum immunity. EFFECT: enhanced effectiveness of vaccine. 3 tbl, 7 ex