anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A process of masking/modifying olfactive/gustatory sensation generated in a user by a base product (7), comprises releasing an aromatic/scenting composition sequenced in a time related to the release of the base product. The aromatic scenting composition is contained in a rupturable capsule. The capsule comprises a rupturable envelope and a core comprising the aromatic/scenting composition. The aromatic/scenting composition is unstable and/or incompatible with the base product. A process of masking/modifying olfactive/gustatory sensation generated in a user by a base product (7), comprises releasing an aromatic/scenting composition sequenced in a time related to the release of the base product. The aromatic scenting composition is contained in a rupturable capsule. The capsule comprises a rupturable envelope and a core comprising the aromatic/scenting composition. The aromatic/scenting composition is unstable and/or incompatible with the base product. The first aromatic/scenting composition contained in the capsule is released by rupture of the capsule before releasing the base product. The second aromatic/scenting composition contained in another capsule is identical/different from the first composition in which the second composition is released by rupture of the capsule constantly during the release of a determined quantity of base product. The base product is present in cream, milk, lotion, gel, ointment, pomade, emulsion, gas, solid dispersion and liquid dispersion. The base product contains a pharmaceutical active ingredient, a pharmaceutical composition, a drug, a cosmetic active agent, a cosmetic care cream, a capillary shampoo product, a coloring capillary/depilatory cream product, active phytopharmaceutical agent or an insecticide. The base product is a yoghourt, a sauce, a drink, a personal hygiene, an oral, domestic or industrial hygiene, detergent, softener and bactericide. Independent claims are included for: (1) a masking/modifying device; (2) a scenting/aromatizing process; and (3) a product obtained by the process.
The patients wear a 12-lead ECG T-shirt for 7 days. During this time period ECG data are measured continuously. In addition the continous glucose monitoring system (CGM) records glucose levels via Dexcom G4-System.
Acute pancreatitis (AP) is an acute inflammatory reaction of the pancreatic tissue, which involves auto-digestion, edema, hemorrhage, and necrosis. AP can be categorized into mild, moderately severe, and severe AP, with severe pancreatitis also referred to as acute necrotizing pancreatitis (ANP). ANP is characterized by the accumulation of necrotic material in the peritoneal cavity. This can result in intestinal injury. However, the mechanism of ANP-associated intestinal injury remains unclear. We established an ANP-associated intestinal injury rat model (ANP-IR model) by injecting pancreatitis-associated ascites fluid (PAAF) and necrotic pancreatic tissue at various proportions into the triangular area formed by the left renal artery and ureter. The feasibility of the ANP-IR model was verified by comparing the similar changes in indicators of intestinal inflammation and barrier function between the two rat models. In addition, we detected changes in apoptosis levels and YAP protein expression in the ileal tissues of rats in each group and validated them in vitro in rat epithelial crypt cells (IEC-6) to further explore the potential injury mechanisms of ANP-associated intestinal injury. We also collected clinical data from patients with ANP to validate the effects of PAAF and pancreatic necrosis on intestinal injury. Our findings offer a theoretical basis for restricting the buildup of peritoneal necrosis in individuals with ANP, thus promoting the restoration of intestinal function and enhancing treatment efficacy. The use of the ANP-IR model in further studies can help us better understand the mechanism and treatment of ANP-associated intestinal injury.NEW & NOTEWORTHY We constructed a rat model of acute necrotizing pancreatitis-associated intestinal injury and verified its feasibility. In addition, we identified the mechanism by which necrotic pancreatic tissue and pancreatitis-associated ascites fluid (PAAF) cause intestinal injury through the HIPPO signaling pathway.
Patients should be informed that glipizide extended-release tablets should be swallowed whole. Patients should not chew, divide or crush tablets.

Patients should be informed of the potential risks and advantages of glipizide extended-release tablets and of alternative modes of therapy. They should also be informed about the importance of adhering to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.

The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure also should be explained.
Background and Objectives: This study aimed to investigate the relationship between the systemic immune inflammation (SII) index and the development of micro and macro complications and mortality within the first year and the following three years in type 2 diabetic retinopathy patients. Materials and Methods: The retrospective study included 523 type 2 diabetic retinopathy patients seen in the endocrinology outpatient clinic of our hospital between January and December 2019. Their demographic and clinical characteristics were analyzed using descriptive statistics. The normal distribution of quantitative data was assessed by the Shapiro-Wilk test. Mann-Whitney U, McNemar-Chi-square, and Cochran's Q tests were used to analyze the SII values and complication rates over time. An ROC analysis determined the sensitivity and specificity of SII. A multiple linear regression analysis examined the relationship between variables and SII, while Spearman's test assessed the correlation between CRP and SII. p < 0.05 was accepted as significant. Results: The mean age of patients was 63.5 ± 9.3 years, with mean SII values of 821.4 ± 1010.8. Higher SII values were significantly associated with acute-chronic renal failure, peripheral arterial disease, and hospitalization rates in both the first year and the following three years (p < 0.05 for all). Significant cut-off values for SII were found for micro- and macrovascular complications and death within the first year (p < 0.05 for all). The ROC curve analysis identified an optimal SII cut-off value of >594.0 for predicting near-term (1-year) complications and mortality, with a sensitivity of 73.8% and specificity of 49.4% (area under the ROC curve: 0.629, p = 0.001). Multiple linear regression indicated that smoking of at least 20 pack-years had a significant positive effect on SII. The Spearman test showed a weak positive correlation between SII and CRP. Conclusions: High SII values predict both early and late acute-chronic renal failure, peripheral arterial disease, and hospitalizations in patients with type 2 diabetic retinopathy. The study also shows that high SII values may predict microvascular and macrovascular complications of type 2 DM and mortality risk in the early period in patients with type 2 diabetic retinopathy. In addition, comorbidities and inflammatory habits, such as long-term smoking, should be considered in the clinical use of SII.
The invention discloses a traditional Chinese medicine composition for treating bamboo rat diarrhea and dysentery. The Chinese medicine composition is prepared from the following Chinese medicine raw materials in parts by weight: 2-4 parts of cherokee rose fruit, 2-4 parts of psidium guajave, 2-4 parts of folium isatidis, 2-4 parts of callicarpa macrophylla, 2-4 parts of atractylodes macrocephala and 2-4 parts of liquorice. The Chinese medicine composition is a preparation obtained by respectively crushing the Chinese medicine raw materials and subsequently mixing or boiling the crushed raw materials. The Chinese medicine composition can be used for effectively checking diarrhea and diarrhea, is safe and effective and free of toxic and side effects, can be used for reducing the application of antibiotics, is less in possibility of drug resistance, and is applicable to treatment on bamboo rat diarrhea and dysentery. The Chinese medicine composition disclosed by the invention can be used for checking diarrhea and diarrhea, and also has the functions of relieving swelling and pain, realizing arresting of secretion and control of bleeding, repairing wound and prompting the cellular immunity. The Chinese medicine composition comprises rosae laevigatae, liquorice and the like, so that not only can the medicine property be conditioned, but also the taste is improved, and the ingestion and digestion of bamboo rats are improved.
The present invention provides novel peptides and vaccines containing them capable or inducing production of antibodies directed against Clostridium perfringens alph-toxin (CPa) in animals to which the) arc administered and thereby providing pro-phylazis against infection by Clostridium pefringens and/or the alpha-toxin itself. Particularly the present invention provides such a vaccine that is relatively safe and simple to produce. e.g. by genetic engineering means. Preferred peptides comprise theo amino acid sequence of Clostridium perfringens alpha-toxin from amino acid 247 to 370 but lack the epitopes necessary for phos-pholipase C and/or sphingomyelin hydrolysing activity round between amino acids 1 to 240 of that sequence. Further provided are antisera and antibodies raised to the peptides and vaccines of the present invention, and particularly monoclonal antibodies and hybridoma cell lines for their production.
Nutri PNEA in a single dose (4 sequences of 10 tablets). Nutri PNEA is a complex of trace elements with the status of a food supplement.
A remote controlled PACS(Picture Archiving and Communication System) and a method thereof are provided to offer a telemedicine service by converting a protocol and performing communication with the converted protocol even if medical or network equipment, and an OS(Operating System) used in other hospitals are different with each other. A web server(31) transceives medical treatment information and opinion among the hospitals. A PACS server(32) stores and converts an image file of the medical treatment information. A database(33) stores a text file of the medical treatment information. A video conference server(36) connects a video conference to make the hospitals exchange the opinions for a patient among the hospitals. The PACS server converts the image file into a DICOM 3(Digital Image and COmmunication in Medicine 3) file.
PURPOSE: A composition for preventing vascularization containing anti-FLT-1 peptide in which mini -peg is welded is provided to effectively treat diseases caused by abnormal or excessive vascularization phenomenon and to enhance convenience of treatment. CONSTITUTION: A composition for preventing vascularization comprises a combination of peptide containing an amino acid sequence described in the sequence number 1(SEQ ID NO:1) and 8-amino-3,6-dioxaoctanoic acid(mini-PEG) as an active component. The peptide is in D form. The peptide controls or interrupts combination between the vascular endothelial growth factor(VEGR) and the VEGF receptor(VEGFR). The composition prevents or treats diseases due to the abnormal or excessive vascularization. The composition is for oral administration or injecting. The oral administration material is manufactured into capsules, tablets, pellets, suspension agent, syrup or powders.
A solid dosage form comprising two or more compounds selected from N,N-dimethyltryptamine (DMT) and its deuterated analogues and pharmaceutically acceptable salts thereof is provided. Preferably the deuterated analogues of N,N-dimethyltryptamine are selected from α,α-dideutero-N,N-dimethyltryptamine and α,β-dideutero-N,N-dimethyltryptamine. The dimethylamine group may also exist in the deuterated form as N(CD3)2. The compounds may be in the form of a pharmaceutically acceptable salt, preferably a fumarate salt, or may be present as the free-base. The solid dosage form is preferably a solid oral dosage form, preferably as a tablet or capsule. The solid dosage form is useful in treatment of a psychiatric or neurological disorder in a patient selected from (i) an obsessive compulsive disorder, (ii) a depressive disorder, (iii) a schizophrenia disorder, (iv) a schizotypal disorder; (v) an anxiety disorder, (vi) substance abuse, (vii) an avolition disorder and (viii) a brain injury disorder.
All the patients received a midluteal long GnRH agonist (GnRH-a) and a gonadotropins (recombinant FSH) stimulation protocol. In the control group, GnRHa (triptorelin, 0.05mg/d,)was used to the day of ovulation trigger.
Chronic obstructive pulmonary disease (COPD) is a chronic disease with a high incidence both in our country and around the world. Dyspnea is one of the common problems in COPD patients. Dyspnea is an important symptom that limits patients' physical mobility, causes psychological problems such as anxiety, depression, and panic, and negatively affects their quality of life. Therefore, it is very important to diagnose and manage dyspnea in patients with COPD. Although pharmacological and non-pharmacological methods are used in the management of dyspnea, it is recommended that pharmacological methods be supported by non-pharmacological methods. Hand fan application, which is one of the non-pharmacological methods used in dyspnea management, provides an increase in self-efficacy in patients in addition to the stimulation of cold airflow to the trigeminal nerve branches, mucosa, and skin. Although there are studies reporting that applying cold air to the face with a hand fan is effective in reducing the severity of dyspnea in different patient groups, the number of studies examining the effectiveness of applying cold air to the face with a hand fan in patients with COPD is quite limited. This project was planned to determine the effect of applying cold air to the face with a fan on the severity of dyspnea and quality of life in COPD patients.

Method: The research was planned as a randomized, controlled experimental design. The population of the research consists of patients treated with a diagnosis of COPD in Bartın State Hospital Chest Diseases Service. Considering the data obtained from a similar study, the sample was calculated as 64 patients in the intervention group and 64 patients in the control group, for a total of 128 patients. Data will be collected using the Descriptive Information Form, Vital Signs Form, Modified Borg Scale, and Saint George Respiratory Questionnaire.

Data will be collected by researchers through face-to-face interviews with COPD patients treated at Bartın State Hospital Chest Diseases Service. Patients receiving treatment with a diagnosis of COPD will be randomized into intervention and control groups. In the control group, the Patient Diagnosis Form, Vital Signs Form, Modified Borg Scale, and Saint George Respiratory Questionnaire Form will be filled in at the first interview. The clinic's routine care protocol will be applied to the patients in the control group, and the researchers will fill out a vital signs form every day for 7 days, and the patients will be followed up. At the first meeting of the intervention group, the Patient Identification Form, Vital Signs Form, Modified Borg Scale, and Saint George Respiratory Questionnaire Form will be filled out. Afterward, training will be given (accompanied by an academic advisor) on how to apply cold air to the face with a hand fan (3 times a day for 5 minutes) for dyspnea management. Additionally, patients will be given a hand-fan application brochure. The researchers will monitor the patient every day for a week (7 days), fill out the vital signs form, and the final test will be administered by the researchers on the 8th day.
UNLABELLED: Pesticides are causing honeybee mortality worldwide. Research carried out on honeybees indicates that application of pesticides has a significant impact on the core gut community, which ultimately leads to an increase in the growth of harmful pathogens. Disturbances caused by pesticides also affect the way bacterial members interact, which results in gut microbial dysbiosis. Administration of beneficial microbes has been previously demonstrated to be effective in treating or preventing disease in honeybees. The objective of this study was to measure under in vivo conditions the ability of two bacterial strains (the Enterobacter sp. and Pantoea sp.) isolated from honeybee gut to improve survival and mitigate gut microbiota dysbiosis in honeybees exposed to a sublethal clothianidin dose (0.1 ppb). Both gut bacterial strains were selected for their ability to degrade clothianidin in vitro regardless of their host-microbe interaction characteristics (e.g., beneficial, neutral, or harmful). To this end, we conducted cage trials on 4- to 6-day-old newly emerging honeybees. During microbial administration, we jointly monitored the taxonomic distribution and activity level of bacterial symbionts quantifying 16S rRNA transcripts. First, curative administration of the Pantoea sp. strain significantly improved the survival of clothianidin-exposed honeybees compared to sugar control bees (i.e., supplemented with sugar [1:1]). Second, curative administration of the Enterobacter sp. strain significantly mitigated the clothianidin-induced dysbiosis observed in the midgut structural network, but without improving survival.
IMPORTANCE: The present work suggests that administration of bacterial strains isolated from honeybee gut may promote recovery of gut microbiota homeostasis after prolonged clothianidin exposure, while improving survival. This study highlights that gut bacterial strains hold promise for developing efficient microbial formulations to mitigate environmental pesticide exposure in honeybee colonies.
The invention discloses a double-ingredient health care medicinal liquor formula capable of relieving cough and eliminating sputum, and purging lung and depressing qi. The double-ingredient health care medicinal liquor formula is invented based on synergism principles that baijiu is provided with treatment effect by drugs, and drug effect is improved by baijiu. The double-ingredient health care medicinal liquor formula is prepared from 100 to 140g of rhizoma cynanchi stauntonii and 450 to 550g of baijiu. A preparation method comprises following steps: rhizoma cynanchi stauntonii is smashed into crude powder, and is packaged with a three-layer gauze bag; the three-layer gauze bag is delivered into a clean container, and baijiu is added for immersion; the clean container is sealed, and is unsealed in one week; the three-layer gauze bag is removed, and an obtained solution is subjected to clarification. 15 to 20ml of the double-ingredient health care medicinal liquor is drunk each time, three times one day; in the morning, the double-ingredient health care medicinal liquor formula is warmed for drinking on an empty stomach. The double-ingredient health care medicinal liquor formula is capable of relieving cough and eliminating sputum, and purging lung and depressing qi, can be used for treating excess syndrome of lung and asthma, cough and profuse sputum, and gastral cavity pain.
PURPOSE: To examine efficacy and safety of ReMEEX implantation in patients with female stress urinary incontinence (SUI) associated with detrusor underactivity (DU), recurrence, or intrinsic sphincter deficiency (ISD).
MATERIALS AND METHODS: Retrospective cohort study included 303 females who underwent ReMEEX system (March 2008 to May 2021). Patients were stratified into three groups by purpose of surgery (SUI with DU, reoperation, and SUI with ISD) and evaluated with following criteria: cure (absence of subjective complaint of leakage and objective leakage in the stress test), improvement (rare leakage subjectively, but satisfaction regardless of stress test), and failure. Primary outcome was success rate of surgery assessed through patient interviews and a stress test. Surgical outcomes and complications were evaluated.
RESULTS: Mean follow-up was 34.4 months (range, 6.0-145.0 months). At the final follow-up visit, 42.9% and 49.2% of patients were cured and improved. Twenty-one point five percent required tension readjustment (mean number, 1.2). The total complication rate was 19.5% (none for grade ≥4). Preoperative Qmax was significantly higher in the ISD group (p<0.001) and preoperative total International Prostate Symptom Score (IPSS) score was significantly higher in the DU group (p=0.044). Moreover, at postoperative 1 year, both total IPSS score and IPSS quality of life score were significantly higher in the DU group (both p=0.001).
CONCLUSIONS: The success rate of ReMEEX system was 92.1% at mean follow-up of 34.4 months in female SUI with DU, reoperation, or ISD. It also enabled postoperative readjustment of sling tension, as needed, up to 130 months after surgery.
OBJECTIVE: To find the common practices among speech language pathologists regarding partner-oriented training for aphasic patients.
METHODS: The exploratory, qualitative study was conducted at Riphah International University, Lahore, Pakistan, from March 1 to May 31, 2021, and comprised speech language pathologists working with aphasic patients for at least 5 years in Lahore, Karachi and Islamabad. Data was collected using a structured interview guide that were conducted online. The recorded interviews were transcribed, and the data was subjected to thematic analysis.
RESULTS: Of the 10 subjects, 6(60%) were females and 4(40%) were males. Overall, 6(60%) subjects had professional experience of >10 years. Thematic analysis showed that most of the speech language pathologists used traditional approaches for aphasia treatment, and counselling of patient's caregiver was done. However, there was no formal tool in Urdu language to provide basic communication strategies for the patient's caregivers or their communication partners. The participants recommended efforts to develop such a tool.
CONCLUSION: There was found a dire need of communication partner training (CPT) programme for aphasia patients and their partners with appropriate linguistic and cultural norms to facilitate them with the aim of improving their quality of life.
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL). Currently, R-CHOP is world-widely used in the first-line treatment for DLBCL. There are about one second of patients suffering relapse and drug resistance. ABC-DLBCL mainly relies on the chronical activity of BCR signal, which can activate the downstream NF-kB pathway through BTK and MYD88, thereby promoting the occurrence of tumors. A study by Wyndham H Wilson et al. showed that 23% of ABC-DLBCL patients were accompanied by acquired functional mutations of the BCR component CD79A/CD79B. Zanubrutinib is a new BTK inhibitor. The goal of our trial is to assess the efficacy and safety of zanubrutinib combined with standard chemotherapy in the treatment for patients with diffuse large B cell lymphoma and CD79A/CD79B genetic abnormality.
(1) The invention provides a composition for hair that imparts to the hair such properties as moist feeling, the feel of smoothness, thick-film touch, and ease of combing. These properties are long lasting and do not disappear after repeated brushing. Furthermore, neither in a moist state during washing, nor in a dry state, the hair produces the feel of unpleasant touch. The hair treated with the composition of the invention does to become sticky after drying. (2) The shampoo compositions of the invention demonstrate superb foamability and washability. The feel of smoothness and ease of combing are not lost even after the repeated hair wash. The composition of the invention comprises a specific block copolymer of polyorganosiloxane and polyoxyalkylene used in the amount of 0.01 to 10 mass %.