anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and neuronal death. Besides aging, various comorbidities increase the risk of AD, including obesity, diabetes, and allergic asthma. Epidemiological studies have reported a 2.17-fold higher risk of dementia in asthmatic patients. However, the molecular mechanism(s) underlying this asthma-associated AD exacerbation is unknown. This study was designed to explore house dust mite (HDM)-induced asthma effects on AD-related brain changes using the AppNL-G-F transgenic mouse model of disease. Male and female 8-9 months old C57BL/6J wild type and AppNL-G-F mice were exposed to no treatment, saline sham, or HDM extract every alternate day for 16 weeks for comparison across genotypes and treatment. Mice were euthanized at the end of the experiment, and broncho-alveolar lavage fluid (BALF), blood, lungs, and brains were collected. BALF was used to quantify immune cell phenotype, cytokine levels, total protein content, lactate dehydrogenase (LDH) activity, and total IgE. Lungs were sectioned and stained with hematoxylin and eosin, Alcian blue, and Masson's trichrome. Serum levels of cytokines and soluble Aβ1-40/42 were quantified. Brains were sectioned and immunostained for Aβ, GFAP, CD68, and collagen IV. Finally, frozen hippocampi and temporal cortices were used to perform Aβ ELISAs and cytokine arrays, respectively. HDM exposure led to increased levels of inflammatory cells, cytokines, total protein content, LDH activity, and total IgE in the BALF, as well as increased pulmonary mucus and collagen staining in both sexes and genotypes. Levels of serum cytokines increased in all HDM-exposed groups. Serum from the AppNL-G-F HDM-induced asthma group also had significantly increased soluble Aβ1-42 levels in both sexes. In agreement with this peripheral change, hippocampi from asthma-induced male and female AppNL-G-F mice demonstrated elevated Aβ plaque load and increased soluble Aβ 1-40/42 and insoluble Aβ 1-40 levels. HDM exposure also increased astrogliosis and microgliosis in both sexes of AppNL-G-F mice, as indicated by GFAP and CD68 immunoreactivity, respectively. Additionally, HDM exposure elevated cortical levels of several cytokines in both sexes and genotypes. Finally, HDM-exposed groups also showed a disturbed blood-brain-barrier (BBB) integrity in the hippocampus of AppNL-G-F mice, as indicated by decreased collagen IV immunoreactivity. HDM exposure was responsible for an asthma-like condition in the lungs that exacerbated Aβ pathology, astrogliosis, microgliosis, and cytokine changes in the brains of male and female AppNL-G-F mice that correlated with reduced BBB integrity. Defining mechanisms of asthma effects on the brain may identify novel therapeutic targets for asthma and AD.
It is currently estimated that 47 million people are living with dementia today and this number is expected to double in the next 20 years. Unfortunately, there has been limited advancement in medical treatments for dementia and new cost-effective approaches are needed. The utility of self-management has been proven to be of benefit in certain chronic diseases, however, very little work has been undertaken regarding self-management in people with dementia.The SHAPE self-management group therapy aims to significantly improve self-efficacy in people with mild to moderate dementia and to improve key health and mental health outcomes, carer stress and knowledge of dementia.SHAPE comprises a 10 week online course delivered as group sessions for the participants with dementia. The sessions are designed to develop self-management skills and to provide information on the disease process and the development of healthy behaviours in a supportive learning environment to prevent problems that are common in the later stages of the disease. E-learning resources will be provided for carers (study supporters) which covers the similar and complimentary material discussed in the group sessions for the participant with dementia.

This trial uses 2:1 randomisation and will assess the clinical and cost effectiveness of SHAPE. Participants will be randomised to participate in the SHAPE intervention or continue with usual care. To assess the effectiveness of SHAPE at improving self-efficacy and secondary outcomes a battery of questionnaires will be administered to the participants and study supporters at baseline, after SHAPE participants have completed the intervention, and 9 months after randomisation. The answers to these questionnaires will be assessed and the results compared between the two groups of participants.
Inflammatory bowel disease (IBD) is a complex disease that develops through a sequence of molecular events that are still poorly defined. This process is driven by a multitude of context-dependent genes that play different roles based on their environment. The complexity and multi-faceted nature of these genes make it difficult to study the genetic basis of IBD. The goal of this article is to review the key genes in the pathophysiology of IBD and highlight new technology that can be used in further research. This paper examines Nanostring RNA probe technology, which uses tissue analyzed without the use of enzymes, transcription, or amplification. Nanostring offers several panels of genes to test, including an inflammation panel of 234 genes. This article analyzes this panel and reviews the literature for each gene's effect in IBD for use as a framework to review the pathophysiology of the disease. The panel was narrowed to 26 genes with significant evidence of mechanistic potential in IBD, which were then categorized into specific areas of pathogenesis. These include gut barrier breakdown, inappropriate recognition of commensal bacteria, immune cell activation, proinflammatory cytokine release, and subsequent impairment of the anti-inflammatory response. The eventual goal of this paper is the creation of a customized panel of IBD genes that can be used to better understand the genetic mechanism of IBD and aid in the development of future therapies in IBD.
To improve the efficacy and tolerability of customary topical applications for transdermal systemically acting pharmaceutical substances, single dosage topical pharmaceutical forms which are therapeutically exactly ready-to-administer are formed from suitable semi-solid pharmaceutical forms. The topical single doses are specified pharmaceutically with respect to their dose, their topical spreading behaviour and their permeation properties. Several of the topically ready-to-administer single doses are in this case accommodated in a common commercial packaging container. Complex treatments can be developed by means of different individual dosages or alternatively active compound combinations. As pharmacological active compounds, steroids, peptides, various analgesics, local anaesthetics and non-steroidal antirheumatics are employed in particular. The single dosage topical pharmaceutical form is a safe, easy to administer and inexpensive application form which makes possible a more exact topical therapy for systemic administrations than could previously be achieved using conventional topical administration forms.
FIELD: medicine. ^ SUBSTANCE: present invention concerns a pharmaceutical multilayered tablet with controlled release representing a three-layer tablet. The specified tablet contains one layer of the first type and two layers of the second type. The layer of the first type contains a pharmaceutically acceptable excipient forming a matrix, and an active ingredient with solubility, highly depending on pH. The layer of the second type contains a pharmaceutically acceptable, pH-supporting excipient, and an excipient forming a matrix. The specified two layers of the second type are identical or are not identical. ^ EFFECT: new dosage form according to the invention allows for constant micro-pH and delivery of the active ingredient with lowered dependence on pH of the environment. ^ 15 cl, 7 dwg, 6 ex
PURPOSE:To prevent the clogging of a container nozzle as far as possible in the case of using a shampoo in a container provided with a pump and to obtain the subject composition having improved dispersibility and safety by compounding a shampoo composition containing fine particles of a water- insoluble solid with an ampholytic surfactant in combination with an acrylic resin. CONSTITUTION:The objective shampoo composition contains fine particles of a water-insoluble solid and is used by filling in a container provided with a pump and ejecting through a nozzle. The composition contains (A) an ampholytic surfactant (e.g. ampholytic surfactant of betaine-type, amidomine- type, imidazole betaine-type, etc.) and (B) an acrylic resin (e.g. a copolymer of ethyl acrylate and sodium methacrylate). The composition is effective in preventing the clogging of the nozzle of the container, keeps the fine particles of the water-insoluble solid in stably dispersed state over a long period and has excellent usability.
Hepatic arterial infusion chemotherapy (HAIC) can significantly improve the local drug concentration in liver compared to systemic chemotherapy. The efficacy of HAIC for hepatocellular (HCC), cholangiocarcinoma, gallbladder, and colorectal carcinoma liver metastasis has been proved by many published studies. HAIC with oxaliplatin and 5-fluorouracil could significantly prolong survival time for HCC patients with portal vein tumor thrombosis (PVTT). Lenvatinib, as a new oral anti-neovascularity inhibitor, was proved to have similar efficacy in HCC patients compared to sorafenib in REFLECT study. The sub-group analysis showed that the median overall survival (OS) in Lenvatinib group was significantly longer that sorafenib group in Chinese HCC patients. Recently, the programmed death-1 (PD-1) inhibitors alone or combined with targeted therapy was explored and confirmed to be effective for advanced HCC, with the median progression-free survival (PFS) and median OS of 2.1-5.6 months and 14.4-22.1 months, resepectively. Thus, the investigators carried out this prospective controlled trial to compare the efficacy and safety of HAIC combined with Lenvatinib and PD-1 inhibitors and Lenvatinib and PD-1 inhibitors for advanced HCC with PVTT.

Total 66 subjects will be recruited in this trial, each group of 33 subjects in treatment group (HAIC-Cola group) and control group (Cola group). The primary endpoint is six-month progression-free survival rate, and the secondary endpoints are OS, overall response rate (ORR), PFS, time-to-progression (TTP) and safety. The safety evaluation will be carried out according to the standard of adverse reaction classification (Common Terminology Criteria for Adverse Events, CTCAE v5.0).
FIELD: medicine, pharmaceutical technology. SUBSTANCE: invention elates to the improved method of preparing doxazosin as the known hypotensive agent used in arterial hypertension and prostate adenoma. Invention describes a method of preparing doxazosin methanesulfonate by doxazosin base and methanesulfoacid dissolving in an organic solvent, filtration of obtained solution followed by isolation of the end product. A mixture of dimethylformamide and butyl acetate taken in the ratio from 1:1 to 5:2 is used as an organic solvent. Method ensures to exclude the use of toxic methanol. EFFECT: improved method of preparing, significantly decreased time of process preparing. 3 ex
Modafinil is a novel wake promoting agent approved in Australia for the treatment of narcolepsy. Preliminary studies have suggested that modafinil may have value in the treatment of psychostimulant dependence through positive effects on mood, sleep patterns, concentration, fatigue and drug craving. It appears to be well tolerated with a low abuse liability. Thirty dependent cocaine users will be randomised to 2 equal groups. The experimental group will receive modafinil 200 mg/day for 10 weeks and a tailored cognitive behavioural therapy program. The control group will receive placebo under equivalent conditions. Primary outcome will be a between group comparison of cocaine negative urine samples collected over the 10 week study period. Adverse events, side effects, compliance, retention, self reported health, psychosocial and drug use outcomes will also be compared between the groups.
Clearance of HCV infection with direct acting antivirals may lead to changes in hepatic function, which may impact the safe and effective use of concomitant medications. For example, altered blood glucose control resulting in serious symptomatic hypoglycemia has been reported in diabetic patients in postmarketing case reports and published epidemiological studies. Management of hypoglycemia in these cases required either discontinuation or dose modification of concomitant medications used for diabetes treatment.

Frequent monitoring of relevant laboratory parameters (e.g., International Normalized Ratio [INR] in patients taking warfarin, blood glucose levels in diabetic patients) or drug concentrations of concomitant medications such as cytochrome P450 substrates with a narrow therapeutic index (e.g., certain immunosuppressants) is recommended to ensure safe and effective use. Dose adjustments of concomitant medications may be necessary.

Table 4 provides a listing of established or potentially clinically significant drug interactions. The drug interactions described are based on studies conducted with either EPCLUSA, the components of EPCLUSA (sofosbuvir and velpatasvir) as individual agents, or are predicted drug interactions that may occur with EPCLUSA [see Warnings and Precautions (5.2, 5.3) and Clinical Pharmacology (12.3)].
Did not receive peanut butter, maintained normal diet and activity. Asked to stop eating 2 hours prior to bed for 7 weeks.
Assessed by World Health Organisation as a pandemic on March 11, COVID-19 is caused by the SARS-CoV-2 coronavirus. The spectrum of its clinical manifestations is strikingly broad and extends from mild disease (resembling an ordinary bout of flu or even asymptomatic) to pneumonia. The latter cases convey a high risk of evolution towards acute respiratory distress syndrome (ARDS), eventually fatal when worsening with cytokine storm and multiple organ failure or with superinfection and sepsis. In the absence of overt variations of the virus itself, its interactions with the host immune system are likely crucial. Clinical features of patients with severe forms of COVID-19 were reported, but immunological description of biomarkers for exacerbation and mortality vs recovery remains superficial. Globally decreased white blood cells, notably T-cells, suggest that CoV-2 might trigger or exploit an immune defect. This could correspond to gaps in immune cell subpopulations, kinetics of activation or repertoires. Immune failure would then be responsible for exacerbations and a poor outcome in intensive care unit (ICU) patients. The objective of the study is to characterize the kinetics of the immune response and of immune dysregulation in ARDS patients. In addition to studying severe ARDS patients, an inverse image of immune repertoires should appear in healed up patients, after they have reached an undetectable viral load and acquired protective antibodies (Abs). Humoral immunity mediated by specific anti-viral Abs was a key factor for recovery from SARS-CoV-1 infection, and this is also expected for CoV-2, making the Ig repertoire also of special interest for its inclusion of anti-viral neutralizing Abs (nAbs).

Altogether, there is thus an urgent need for high-resolution characterization of the anti-CoV-2 immune response, correlating the dynamics of immune activation, cytokine production and immune repertoires with clinical evolution. In addition to providing biomarkers for prognosis evaluation and for monitoring innovative treatments this will also participate to the urgent quest of as many possible monoclonal antibodies (mAb) candidates for immunotherapy
The invention discloses a liquid medicine with the acupuncture effect. The liquid medicine is prepared from extracts of the following raw materials: notoginseng, angelica, cassia bark, radix salviae miltiorrhizae, borneol, rhubarb, hemlock parsley, peach seed, safflower, red paeonia, pollen typhae, mastic, myrrh, menthol and musk. By fully maintaining and taking the traditional effects of traditional Chinese medicinal materials on activating blood circulation to dissipate blood stasis, dispersing swelling and relieving pain, and expelling wind and removing damness, the invention has high efficiency and strong power because of the combined action of medicinal treatment effect, heat treatment effect and moxibustion treatment effect, combines the pain-relieving and swelling-dispersing effects of the medicine and the refrigerating and heating agent, and has the advantages of convenient carrying and use. The liquor can be forced to permeate as long as a small amount of liquid medicine is dropped on points or affected parts by the palm or is covered by a preservative film and can maintain the constant temperature to generate heat, and the maximum heat-generating time can last for 24 hours. The temperature of the liquor can be adjusted under 55 DEG C, and the contents of the active ingredients can be adjusted at discretion. The liquid medicine can realize the expectant administration and the expectant treatment based on different symptoms, and achieves the effect more satisfactory than the acupuncture.
Individuals with serious mental illness (SMI) experience increased cancer mortality because of inequities in cancer care. Access to mental health and cancer care remains inadequate. Virtual tumor boards have been associated with higher rates of patients receiving guideline-concordant cancer care, but these tumor boards have not been adapted for cancer and mental illness. A virtual cancer and mental health tumor board intervention has potential to increase access to psycho-oncology and oncology expertise, facilitate clinician communication, and may address barriers to cancer and mental health care. The purpose of this study is to examine the feasibility and acceptability of a virtual tumor board for cancer and mental illness for our target population for patients and clinicians. We will also explore changes in cancer care, psychiatric symptoms, and clinician self-efficacy in managing this population. This study is a single-arm pilot (n = 30) based at a cancer center affiliate and the surrounding community. The intervention includes proactive identification using a registry, bi-monthly virtual equity tumor board focused on cancer and mental health using HIPAA-compliant videoconference that uses co-learning, assessment of barriers to cancer care, strengths, and goals of care, creating plans that identify who is responsible for next steps and patient communication, and relaying recommendations to patients and the treating oncology team.
At the end of the operation, a right-sided subcostal transversus abdominis plane block will be applied to the patients by ultrasound aided. While applying the subcostal transabdominal plan block, %2,5 Marcaine 20 ml will be given between the transverse and rectus abdominis muscle immediately next to the linea semilunaris. Patient-controlled analgesia devices with Tramadol will be prepared for postoperative analgesia. Rest and coughing pains, nausea and total PCA consumption will be recorded10 minutes, 30 minutes, 1, 3, 6, 24 hours postoperatively. Verbal Numerical Rating Scala (0 = no pain; 10 = the most severe pain you can imagine) for pain and Categorical Scoring Method (0 = none; 1 = less; 2 = too; 3 = too much) for nausea will be used. Complications such as infection, bleeding, and subcutaneous emphysema will be recorded.
The invention discloses a viburnum sargentii branch and leaf lignan, an extraction method and application. The extraction method comprises the steps of smashing dried viburnum sargentii branches and leaves, and the like; using a constant-temperature ultrasonic instrument for suspending an extract with warm water, extracting, and decompress concentrating to obtain an extract; dissolving the extract at a cholorform part in methanol, eluting to remove chlorophyll, carrying out chromatography and purification to obtain 5 different compounds. A monomer lignan obtained through the invention has the purity achieving 96 percent to 99 percent, can be subjected to goal-oriented structural modification, and is applied in pharmaceutical synthesis so as to obtain pharmaceutical molecules with better activity; 5 lignans are firstly extracted from viburnum sargentii , so that an approach for obtaining such natural active ingredients is wider. The extraction method provided by the invention is simple and convenient, easy to separate and recover an organic solvent mixture, less in emission, and suitable for modern fine industrial production. The invention adopts a latest SBC MCI GEL reversion phase chromatography filler, so that the removal rate of chlorophyll is improved from 60 percent to 70 percent to 97 percent to 100 percent. The invention discloses anti-atherosclerosis application of the lignan monomer.
A unitary dental device constructed from a suitable thermoplastic or thermosetting material allowing the dental device to be heat molded by a dental practitioner sitting chair side to a patient.  The dental device includes a single-piece, shell-like analogue having the appearance of contoured, individual teeth. The dental device may also include a pair of posterior tooth extensions in order to create a custom buccal corridor specifically adapted for the patient. A  connection bridge uniformly joins the proximal contact areas intermediate of adjacent teeth to form the unitary shell-like analogue. The dental device may be temporarily affixed in the patient's mouth to allow both the patient and the dental practitioner to preview chair side the look of a final smile design with a fully-fabricated dental prosthesis. Once the patient and dentist are satisfied with the particular tooth selection and characterization, the dental prosthesis can be fabricated from the dental device.
The invention provides a nasal sticker for removing blackheads and shrinking pores. The nasal sticker comprises a sticker main body. The sticker main body is composed of an upper sticking area, a lower sticking area and a medicine area. A medicine composition is attached to the surface of the medicine area. The medicine composition is prepared from, by weight, 2-4 parts of bentonite, 5-8 parts of charcoal dust, 3-7 parts of Moroccan lava clay, 2-4 parts of witch hazel extract, 3-5 parts of aloe barbadensis leaf extract, 5-8 parts of chamomile extract, 6-8 parts of bioflavonoid, 2-4 parts of tea tree oil, 6-9 parts of licorice extract, 2-4 parts of arnica extract, 1-3 parts of sol protease and 36-61 parts of cationic water. The nasal sticker has the following beneficial effects that sebum and blackheads on the nose can be adsorbed through the bentonite, the charcoal dust and the Moroccan lava clay, and the effects of soothing skin and shrinking pores are achieved through the chamomile extract, the bioflavonoid, the tea tree oil, the licorice extract and the arnica extract.
The treatment group will receive the stepped-care program consisting of Doing What Matters (DWM) (step 1) and Problem Management Plus (PM+) (step 2), in addition to Psychological First Aid (PFA) and care as usual (CAU). Step 2 will only be provided if the participant still has elevated levels of psychological distress (K10 \> 15.9) at 2 weeks after DWM, i.e. during the second quantitative assessment at 2 weeks after DWM.