anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Spontaneous supratentorial intracerebral haemorrhage (SSICH) is the second most common form of stroke and accounts for approximately 2500 cases in Switzerland annually. The prognosis is very poor with nearly half of the patients dying within one year after haemorrhage. Treatment options for SSICH consist of either the current gold standard, best medical treatment (BMT), or surgical hematoma evacuation. Neither the best medical treatment nor the established surgical mainstay (conventional craniotomy) have shown relevant improvement of survival or functional outcome rates. A minimal invasive approach with early image-guided endoscopic surgery conducted within 24 hours after bleeding onset is therefore proposed. Endoscopic surgery was shown to be safe and effective, however large trials analyzing the benefits of endoscopic surgery are lacking. An earlier, more complete and more rapid hematoma evacuation could improve the functional outcome and mortality rates in affected patients. The primary objective of this two-armed, open-labelled, single centre randomised controlled trial is to show superiority of early minimally invasive image-guided hematoma evacuation additionally to BMT compared to BMT alone in improving functional outcome rates at 6 months in patients with SSICH. The study procedures include 6 visits in total, 4 of them during hospital stay, 2 of them as follow-up visits within the clinical routine. Each visit consists of assessing Glasgow Coma Scale (GCS), modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS), three visits include CT scans (before intervention, directly postoperative and during follow up) and blood sampling (before intervention, postoperative and during follow up). Three visits include assessing patient satisfaction and cognition, and two visits include patient quality of life assessments. This study was designed in collaboration with Patient and Public representatives.
Patients with high-risk prostate cancer have a high probability of PSA failure after radical prostatectomy. However, more than half of these patients will remain free of PSA recurrence for more than 10 years. To the contrary, patients with early PSA recurrence and a doubling time less than 10 months have a mortality rate approaching 50% at 10 years despite hormone therapy. Although androgen deprivation therapy (ADT) remains the standard treatment for patients with early and rapidly rising PSA after prostatectomy, this treatment is not curative on the long term for most patients. The recent demonstration of activity of Taxotere (docetaxel) in a high proportion of patients with advanced metastatic disease has stimulated a great interest in it use at an earlier stage of the disease. Recent studies performed in animal models of prostate cancer suggested that the response rate of prostate cancer cells to docetaxel-induced cell death was significantly enhanced by androgen stimulation in AR-positive, androgen-dependent prostate cancer cells (i.e. before ADT). Therefore, this protocol proposes to assess the response rate to primary Taxotere chemotherapy in patients with early and rapid PSA rising after prostatectomy for high risk disease.
Patients randomized in control arm A will receive four cycles of neoadjuvant chemotherapy with FLOT every two weeks (5-FU 2600 mg/m² d1, folinc acid 200 mg/m² d1, oxaliplatin 85 mg/m² d1, docetaxel 50 mg/m² d1) followed by surgical resection 4-6 weeks after day 1 of the last cycle of neoadjuvant therapy. 6-12 weeks after surgery adjuvant chemotherapy starts with 4 cycles of FLOT (total treatment period 25-32 weeks).
Eligible participants entering a run-in period of 21 days (Days -28 through -8) will receive Loestrin (EE and NEA) to stabilize on the combined OCs containing EE and NEA to synchronize the menstrual cycles of multiple participants. Participants completing the run-in period will enter Treatment Period 1 and will be administered Loestrin once daily from Days 1 to 10. On Day 11, participants will enter Treatment Period 2 and will be administered Loestrin + VH4524184 once daily from Days 11 to 20.
Alzheimer's disease (AD) is characterized by a progressive deterioration of cognitive functions with episodic memory loss and spatial disorientation (SD) as main features. Getting lost in community due to AD is associated with a wide range of negative consequences, such as a strong decrease in patients' quality of life. Episodes of SD in the elderly can increase the possibility of being recovered in a nursing home, caused by a loss of the sense of autonomy as well as an increase in potential injuries and, in the worst cases, even death. Additionally, caregiver burden and increased stress, as well as scarce community resources represent other significant problems related to patients' SD. New technological solutions, such as virtual reality (VR), represent promising means for AD assessment and intervention, especially when they can reveal poor ecological performances. In addition to the advanced age, the ε4 allele of Apolipoprotein-E (APO-E) represents the most important risk factor for AD, providing the opportunity to evaluate subclinical behavioral alterations in individuals with subjective cognitive decline (SCD), and Mild Cognitive Impairment (MCI) due to AD, which represents the prodromic phase of dementia. Deterioration of spatial navigation (SN) abilities is often present early in the course of AD. Therefore, a better understanding the neural mechanisms related to SN impairment in patients at high risk of developing AD can help timely diagnosis and intervention. The present study, adopting a technological apparatus for the detection and the rehabilitation of SN deficits, aims to: (i) investigate the performances obtained on SN tasks in a sample of community-dwelling older adults grouped into three levels (healthy controls, individuals with SCD and patients with MCI due to AD), undergoing virtual (The AppeGame) and naturalistic open-space tests (Detour Navigation Test-modified version); (ii) correct SN deficits by computer-based cognitive remediation sessions and VR sessions; (iii) educate participants at high risk of developing dementia about the opportunity offered by technology in supporting SN in exploring urban circuits.

We will analyze results of the virtual and ecological tasks of SN as a function of age, ApoE genotype and belonging of one the three groups, using a multiple linear regression model. The subgroups of participants at highest risk of developing AD will be administered the aforementioned combined cognitive rehabilitation sessions, with a test/retest analysis. Finally, through an online technological monitoring system, participants will be provided personalized feedbacks via smartphone digital health applications connected to a wearable equipped with sensors, in order to self-manage during their journeys alone in urban environments thanks to the use of threshold algorithms capable of supporting their SN.
Preeclampsia still remains a leading cause of feto-maternal mortality and morbidity in developed and developing world. Despite of intensive research, the underlying pathologic mechanisms of this disease remain elusive. It has been agreed that incomplete or absent transformation of spiral arteries by replacing endothelial cells and mural vascular smooth muscle cells has been observed in the placental bed of preeclamptic patients and severe cases of intrauterine growth restriction. Oxidative stress has been proposed as a link between these mechanisms. However, it has been demonstrated by two large studies that antioxidant supplementation does not reduce the risk of preeclampsia. Our initial study has been shown that antioxidant supplementation may be reduce the risk of preeclampsia in pregnant women with low antioxidant status.

Comparison(s): adverse pregnancy outcome between vitamin C and E given and placebo given to pregnant women with low antioxidant status at 10-12 weeks gestation age
Embodiments described herein provide for receiving a second image comprising an overlay depicting an organ-at-risk (OAR) segmentations. The overlay is generated by a first machine learning model based on a first image depicting the anatomical region of a current patient. A second machine learning model receives the second image and set of third images depicting prior patient OAR segmentations on which the second machine learning model was trained. The second machine learning model classifies the second image as one of a set of class names and characterizes the extent to which the second image is similar to, or dissimilar to, images with the same class name in the set of third images. The characterization may be based on outputs of internal layers of the second machine learning model. Dimensionality reduction may be performed on the outputs of the internal layers to present the outputs in a form comprehendible by humans.
The invention discloses health care wine for improving memory and a preparation method. The health care wine for improving memory is composed of 30-40 g of centella asiatica, 30-40 g of dried longan pulp, 10-20 g of ginseng, 10-20 g of red dates, 30-40 g of astragalus, 10-20 g of lotus seeds, 30-40 g of Japanese knotweed and 1000-1500 g of 60-degree baijiu. The preparation method comprises the steps of performing rough machining of medicines; bagging the medicines and using medical stone water to soak the medicines for 24 h; placing the soaked medicines in baijiu, and storing the baijiu for 1 year in a cella, so that the health care wine can be drunk. When the health care wine is drunk, medicine residue is filtered out. The health care wine complements deficiency, reinforces intelligence, nourishes blood and the heart and prolongs life. The health care wine is suitable for treating indications of liver and spleen disorder, amnesia, consumptive disease, spiritual mechanism apraxia, brain hollowness and malnutrition of heart spirit caused by insufficiency of qi and blood and the like; the health care wine is suitable for health care of middle-aged and aged people, and through tests of 780 people for 20 years, the effective rate reaches 95%.
Tea with an anti-tumor effect is characterized by being prepared from the following raw materials, by weight, 300-330 parts of fresh tea leaves, 20-24 parts of fresh Chinese yam, 6-8 parts of lucid ganoderma, 3-4 parts of fresh ginger, 5-8 parts of fructus arctii, 8-10 parts of prunella vulgaris, 2-4 parts of bamboo leaves, 4-5 parts of coptis, 5-7 parts of isatis root, 10-12 parts of rock sugar, 8-10 parts of honey, 12-15 parts of purslane, 15-17 parts of gourd seeds, 10-12 parts of Pericarpium Citri Reticulatae, 3-5 parts of colleseed oil, 20-24 parts of tomato, 4-6 parts of tomato seeds, 4-5 parts of an auxiliary agent and 200-250 parts of water. The tea provided by the invention is tea with an antitumous effect. Causes of cancers are greatly related with diet. In the invention, by a preventive method of decocting Chinese herbal medicines with an antitumous effect, such as ginger, arctium fruit, prunella vulgaris, bamboo leaf and the like, active ingredients are added into tea, thus imperceptibly increasing immunity when drinking the tea. Meanwhile, selenium in tomato is considered as an antitumous expert. A medical soup is decocted and concentrated and finally sprayed in a spray form onto the surface of tea; and by a special process of microwave deactivation of enzymes, the active ingredients permeate with violent vibration of water molecules into the tea. During immersion, tea and water are blended, thus producing excellent efficacy and taste.
PURPOSE:To obtain the titled vaccine on an industrial scale, by cultivating Bordetella pertussis with aeration and agitation under specific conditions, increasing an infection protective antigen HA fraction together with the multiplication of the Bordetella pertussis, and detoxicating the above-mentioned HA fraction in the presence of an amino acid. CONSTITUTION:Bordetella pertussis is inoculated into a liquid culture medium containing cyclodextrin or a derivative thereof. In the process, the cultivation temperature is kept at 20-37 deg.C, and the amount of dissolved oxygen in the culture medium is kept at 0.7-6ppm. Furthermore, the culture medium is preferably defoamed under conditions of 6<pH<9 for the cultivation with aeration and agitation. The aimed infection protective antigen HA fraction is then collected in the bacterial growth stage in the ogarithmic growth phase or stationary phase and then detoxicated in the presence of an amino acid, e.g. glycine or methionine. The resultant detoxicated HA fraction can be used to produce purified pertussis vaccine, precipitated purified pertussis vaccine, precipitated purified pertussis and diphtheris and tetanus mixed vaccine, etc. economically in large amounts.
In an echocardiography analysis method, a diagnostic code for an echocardiography including a cyclic set of echocardiographs is received or generated. A plurality of different subsets are selected from the echocardiograms. Each subset consists of one or more echocardiographic cycles in the set of echocardiographic cycles. For each subset, a confidence score indicating the relevance of the subset to the diagnostic code is determined using an Artificial Intelligence (AI) engine operating on the subset, wherein the AI engine is trained on historical echocardiograms labeled with the diagnostic code. A set of related echocardiographic cycles is identified based on the determined confidence scores for the respective subsets that are indicative of the relevance of the respective subsets to the diagnostic code. An echocardiogram reading user interface is presented including displaying a diagnostic code associated with an echocardiogram cycle of the associated echocardiogram cycle group.
The enrolled participants will undergo a questionnaire investigation and receive a risk assessment for esophageal and gastric malignancies based on two questionnaire-based diagnostic models. Participants identified as "high-risk" (i.e., with a top 50% risk level) for esophageal and/or gastric malignancy will receive the standard upper gastrointestinal endoscopy. Standardized diagnosis and treatment recommendations will be provided to patients with screening-detected malignant lesions, and green referral channels will be established for them. For participants with screening-detected premalignant lesions, the risk of progression will be evaluated based on endoscopic characteristics, pathological diagnosis, and biomarkers. Individualized reexamination and surveillance will be implemented accordingly.
Spine fusion is an involved procedure during which patients are at risk for significant intra-operative blood loss. The resulting hypovolemia increases the fluctuations in arterial pressure associated with positive pressure ventilation. These respiratory induced arterial pressure variations (RIAPV) appear as cyclical peaks and troughs on the arterial waveform.

Different approaches have been used to quantify the RIAPV. One such approach has been to measure the pulse pressure variation (PPV), using invasive arterial monitoring. In previous studies, PPV has been shown to be a good indicator of fluid responsiveness intra-operatively, but this has not been specifically evaluated in patients undergoing spine fusion. This patient population is of particular interest because of their underlying scoliosis as well as their prone position during the operation. These two variables could potentially alter lung-thorax mechanics in a manner which may influence RIAPV, which is specifically determined by the interaction between intrathoracic pressure and venous filling of the heart. A second approach to quantifying RIAPV relies on non invasive technology initially developed by the Masimo Corporation for pulse oximetry. This parameter has been coined pleth variability index (PVI), as it specifically quantifies real time changes in the plethysmogram associated with respiration. PVI, which is based on arterial blood volume changes, is therefore analogous to PPV, which is derived from changes in arterial pressure. To date PVI has only been evaluated in adult patients undergoing cardiac surgery and the data suggest that it may be a useful indicator of fluid responsiveness.

Given the non-invasive and continuous nature of PVI, it is appealing for potential use as a bedside monitor to guide fluid resuscitation. However, photoplethysmography is known to be sensitive to noise due to motion, light and electrical interference. Furthermore, PVI is based upon a degree of quantitative evaluation of the photoplethysmogram that is the first of its kind. For these reasons, it is important to understand the limits of agreement between PVI and PPV before we can accept PVI as a non-invasive surrogate measurement. This study intends to evaluate PVI by analyzing it in relation to PPV. More specifically, paired measurements of PPV and PVI will be compared to determine the limits of agreement between the two parameters in patients undergoing spinal fusion.
Fibroblast growth factor-21 (FGF-21) and Visfatin are associated with obesity. However; reviewing the literature; no studies were found to assess their role as potential markers for the metabolic disorders related to obesity in children. Assess the relations between serum FGF-21 and Visfatin with obesity and its metabolic disorders, and their use as potential predictors for metabolic risk factors in a sample of Egyptian obese children. This cross-sectional study included 111 Egyptian children (45 males and 66 females); aged 6-10 years to avoid the effect of puberty (prepubertal). The exclusion criteria (by full History taking and clinical examination) were the presence of any sign of puberty according to Tanner stage, the presence of identified causes of obesity (genetic syndromes, chromosomal or endocrinal disorders), chronic diseases (cardiovascular, gastrointestinal, and respiratory), or drug use like steroids; that would interfere with the type of obesity and affect the normal growth of the children. Also, any child with a BMI between 85 and 95th percentiles (overweight) was excluded from the study. All participating obese children were suffering from exogenous simple obesity. They were classified according to their body mass index (BMI) percentiles into 72 obese (BMI ≥ 95th), and 39 control non-obese ones (BMI > 15th to < 85th), based on the Egyptian Growth Charts for children and adolescents. Ethical approvals were granted from both the Ethics Committee of the "National Research Centre" and the "Faculty of Postgraduate Childhood Studies" (Approval No. 17/125). Also, informed written consent was taken from either of the parents and assent from the participating children. They were subjected to blood pressure assessment, anthropometric measurements (weight [Wt], height [Ht], BMI, waist [WC], and hip [HC] circumferences), and laboratory evaluation (Visfatin, FGF-21, LDL, HDL, TG, cholesterol, fasting glucose, insulin, and calculation of HOMA-IR). Mann-Whitney test and Spearman's correlation test were applied. Obese children had significantly higher values than control ones regarding all the studied clinical (SBP, DBP), anthropometric parameters (Wt, Ht, BMI, WC, and HC), FBG, Insulin, HOMA-IR, Visfatin, and FGF-21, and had significantly lower values regarding HDL and Cholesterol. Among obese children, both FGF-21 and Visfatin had significant negative correlations with BMI and HC. At the same time, serum FGF-21 had a highly significant positive correlation with HDL. Visfatin and FGF-21 had highly significant positive correlations with each other. In the control group, both serum Visfatin or FGF-21 had insignificant correlations with each other and with all the studied clinical and anthropometric parameters. FGF-21 and Visfatin are related to the obesity markers, but they cannot be used as potential predictors for metabolic disturbance in obese prepubertal children; both had insignificant correlations with the metabolic risk factors.
The invention provides a compound medicine for treating skin itch and a preparation method thereof and relates to the technical field of traditional Chinese medicine. The compound medicine has curative effects of clearing away heat and toxic materials, promoting diuresis to eliminate dampness and relieve itching, and tonifying the spleen and the lung. The compound medicine is mainly made of raw material medicines. The raw material medicines comprise, by weight parts, 10-30 parts of folium isatidis, 8-20 parts of coix seeds, 10-18 parts of tribulus terrestris, 10-18 parts of smilax glabra, 8-18 parts of fortune eupatorium herb, 8-10 parts of gallnut, 10-15 parts of Chinese yam, 8-15 parts of salviae miltiorrhizae, 7-12 parts of honeysuckle, 7-12 parts of bitter apricot seeds, 5-8 parts of radix glycyrrhizae and 4-10 parts of rice-grain sprouts. The method for preparing the compound medicine comprises the steps of performing extraction, concentration and drying to obtain dry extract, performing extraction to obtain volatile oil, reasonably recycling medicine residue, mixing the dry extract, the volatile oil and pharmaceutical excipients, and making various dosage forms of the compound medicine. Each parameter of the preparation method is clear, the process is short, and the operability is high.
Technological developments and the pandemic have popularized the distance learning model at universities. In this educational model, students spend more time in front of screens, and screen-related health conditions have become important. This cross-sectional study of 177 undergraduate students was designed to investigate the effect of block and traditional scheduling in online distance education (ODE) on their musculoskeletal pain and to investigate their perceptions of block scheduling. A two-stage method was used: a quantitative design to compare pain levels, and a qualitative design to determine the students' perceptions of block scheduling using an online survey. Pain intensity was assessed using the Numeric Rating Scale (NRS-11). Data were collected in the university health sciences department. Pain intensity following the block and traditional lessons was analyzed using a paired t-test. Students in the block schedule had significantly more pain, with a large effect size on the whole trunk and upper limbs. Pain levels were also clinically meaningful for the upper (5.73 ± 2.75), lower (5.59 ± 2.87), and neck (4.92 ± 2.60) regions. Students reported positive experiences with block scheduling in ODE such as saving time (43%) and maintaining subject integrity (26%), but also negative experiences such as distraction (56%), fatigue (33%), pain (17%), and boredom (11%). Block scheduling in ODE could cause clinically significant neck and back pain. In distance learning, keeping the course duration short and ensuring student mobility in the classroom are important.
The invention provides a preparation method of an externally applied medicinal pad for treating cold palace. The externally applied medicinal pad disclosed by the invention is composed of leonurus, Chinese angelica, liquorice, rhizoma zingiberis, folia perillae acutae, folium artemisiae argyi, ligusticum wallichii and the root of kudzu vine. The medicinal pad disclosed by the invention is prepared through the steps of processing liquid medicine, processing medicinal liquor and preparing the medicinal pad. The externally applied medicinal pad prepared by adopting the method disclosed by the invention has the effects of invigorating the circulation of blood, removing stasis, replenishing blood, regulating menstruation, relieving pain, detoxifying, returning to Yang, promoting coronary circulation, eliminating cold to stop pain and removing cold, heat and pathogenic factor. The curative rate on cold palace is up to 93.5%. The externally applied medicinal pad disclosed by the invention is applied to curing cold palace.