anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a Chinese medicine preparation for curing tetanus. The formula includes earthworm, cicada ecdysis, rhizoma gastrodiae, notopterygium root, parsnip, herba schizonepetae, rhizoma arisaematis, uncaria, red peony, alum, ophiopogon japonicus, cortex moutan, Indian bread with hostwood, root poria, centipede, whole worm, atrina glass, honeysuckle, hemlock parsley, forsythia, safflower, peach seed and angelica. In the formula, the raw materials are pulverized, filtered and then made into pulvis. During the medicine taking, the medicine is mixed with cold boiled water, with two or three times per day and three days is one treatment period. The Chinese medicine preparation, compared with the prior art, is scientific and reasonable in the formula, simple in the regrouping of the raw materials and preparation process, effective in reducing the treatment cost and remarkable in treating tetanus. Having no toxic side effects to the human body, the invention is the medicine prepared commonly in homes.
Disclosed is a sterol derivative, which has an effect of promoting the proliferation of nerve stem cells, or a pharmaceutically acceptable salt of the same. Specifically disclosed is a sterol derivative represented by general formula (I) [wherein Y represents an optionally substituted lower alkyl, etc.; X a  and X b  are the same or different and represent a bond, etc.; R 1 , R 2 , R 3 , R 4 , R 7  and R 8  are the same or different and represent a hydrogen atom, etc.; R 5  and R 6  are the same or different and represent a hydrogen atom, etc.; R 9  represents a hydrogen atom, etc.; R 10  and R 11  together form a bond, etc.; and R 12  represents a hydrogen atom, etc.], a pharmaceutically acceptable salt of the same, or the like.
In this study, the protocol applied to automatic electronic blood pressure system module BN1 for performance evaluation is ISO's proposed "ISO 81060-2:2018 Non-invasive sphygmomanometers- Part2: Clinical investment of internal automatic measurement type". The initial BP measurement is performed alternately, measuring the blood pressure by the measurer and the test device once each, and measuring blood pressure by the measurer four times by the observer and three times by the test device.
With the study hypothesis that Gatifloxacin is superior to Ceftriaxone in terms of treatment failure in patients with enteric fever, a comparative study will be conducted at Patan Hospital. 300 patients who are diagnosed with enteric fever will be enrolled into the study. The patients will be randomized to one of two groups. One group will receive treatment with Gatifloxacin for 7 days, and the other with Ceftriaxone. The patients will be followed during the treatment courses and at several points of 6 months after initial presentation. The endpoints then will be compared between two groups.
A liquid spray device 10 comprising a spray dispenser (20, fig 1) having a body portion comprising a receptacle (22, fig 1) containing a liquid sanitising composition, and a selectively operable spraying device for dispensing the liquid; and a piece of cloth 52 attached to and overlaying at least a portion of the outer surface of the body portion. The liquid sanitising composition comprises at least 70% wt. alcohol and up to 30% wt. water. Further discloses is a sprayable liquid sanitising composition. The composition preferably comprises chlorhexidine digluconate as an antiseptic agent up to 1% wt. The composition may further comprise aloe barbadensis gel, vitamin E, PEG 40 hydrogenated castor oil, triethanolamine, and aroma or fragrant compounds. The cloth may be a microfibre cloth.
1,132,264. Purification of synthetic peptides. FARBWERKE HOECHST A.G. 24 Jan., 1966 [23 Jan., 1965], No. 3106/66. Heading C2C. Synthetically prepared polypeptides having a corticotropin-sequence of amino acid residues within the range from 1-18 to 1-25 or an analogous synthetic peptide in which one or more of the individual amino acids are replaced by the same number of other amino acids having a similar structure provided that the ACTH activity is maintained are purified by precipitating a tert.-butyl and tert.-butyloxycarbonyl protected peptide from a solution in aq. alc. (containing 1-3 C) by means of AcOH containing NH 4 OAc, removing the protecting groups with CF 3 COOH and chromatographing the free peptide dissolved in aq. NH 4 OAc solution on carboxy methyl cellulose.
The iABCT is a self-applied program based on the attachment theory and the use of compassion meditations. It is composed of 8 modules that have been reformulated to be completely self-applied and include text, images, illustrations, videos, audio with guided meditations, exercises, and homework. Downloadable PDF files will be made available so that users can review them offline. Each module has been optimized to have a duration of 60 and 90 minutes approximately. The entire intervention is estimated to be completed in eight weeks.
BACKGROUND: Failure due to trunnionosis with adverse local tissue reaction (ALTR) has been reported with cobalt-chrome (CoCr) heads in total hip arthroplasty (THA); however, there are limited data on the use of these heads in the revision setting. The purpose of this study was to analyze the outcomes of patients who underwent revision THA with a retained femoral component and received a CoCr femoral head on a used trunnion.
METHODS: In this retrospective review, we identified all patients who underwent revision THA with a retained femoral component and received a CoCr femoral head between February 2006 and March 2014. Demographic factors, implant details, and postoperative complications, including the need for repeat revisions, were recorded. In total, 107 patients were included (mean age 67 years, 74.0% women). Of the 107 patients, 24 (22.4%) required repeat revisions.
RESULTS: Patients who required repeat revision were younger than those who did not (mean age: 62.9 versus 69, P = .03). The most common indications for repeat revision were instability (8 of 24, 33.3%), ALTR (5 of 24, 20.8%), and infection (4 of 18, 16.7%). Evidence of ALTR or metallosis was identified at the time of reoperation in 10 of the 24 patients who underwent re-revision (41.7%).
CONCLUSIONS: The placement of a new CoCr femoral head on a used trunnion during revision THA with a retained femoral component carries a significant risk of complication (22.4%) and should be avoided when possible.
PURPOSE: A composition containing Glycyrrhiza Uralensis Fischer extract is provided to suppress pigmentation and/or scar by acne and to be used in cosmetic or medical field. CONSTITUTION: A composition for suppressing pigmentation or scar by acne contains Glycyrrhiza Uralensis Fischer extract as an active ingredient. The Glycyrrhiza Uralensis Fischer extract suppresses gelatinase. An external use composition contains the composition for suppressing pigmentation or scar. The composition is a cosmetic formulation. An aftercare composition for acne sequel contains Glycyrrhiza Uralensis Fischer extract as an active ingredient.
A detergent hair care compsn. contains, in (a) a cosmetically acceptable medium, (b) a washing base, (c) a cationic polymer and (d) a water-sol. or -dispersible silicone deriv. comprising a main siliconised chain onto which is grafted an anionic hydrocarbon gp.. Use of a siliconised deriv. to improve the styling effect of a detergent hair-care compsn. contg. a cationic polymer is claimed.
A method of improving cumulative embryo score may comprise administering an androgen to a human female for at least about four consecutive months followed by harvesting and fertilizing oocytes and forming embryos. A method of increasing the quantity of fertilized oocytes in one cycle of in vitro fertilization may comprise administering an androgen to a human female for at least about four consecutive months, harvesting and fertilizing the oocytes. A method of normalizing ovarian DHEA may include administering an androgen for at least about four consecutive months. A method of decreasing the time to pregnancy and increasing the rate of pregnancy by administering an androgen for at least about two months. A method of decreasing miscarriage rates may comprise administering an androgen for at least about two months to a female. Moreover, a method of decreasing aneuploidy rates in human embryos may comprise administering an androgen to a female for at least about two months.
<P>PROBLEM TO BE SOLVED: To provide a remote-controlled diagnosis system, in which a doctor actually diagnosing a patient can specify the optimum photographing conditions for his diagnosis purpose and instruct another doctor about appropriate photographing under the specified conditions.  <P>SOLUTION: A requesting hospital 10 has a photographing means 11 such as a fundus oculi camera to take its photos, and a terminal 12 for requesting a diagnosing doctor 10A to record photographed images, examination and patient data, etc. and request another doctor for diagnosis. The terminal 12 used for this request is connected with a management server 20 via a network such as a LAN or the Internet, and the request to another doctor for diagnosis is done by transmitting a diagnosis request slip to the management server 20 and registering the relevant data there. The management server 20 has a means to register and store the photographing conditions, etc. suitable for photographing purposes, and can be connected with the diagnosis-use terminals 31A, 31B and 31C of diagnosing doctors 30A, 30B and 30C of the requesting hospital 10 registered through the network.  <P>COPYRIGHT: (C)2004,JPO
PURPOSE:To carry out the separation and purification of ceruloplasmin, in high efficiency, by contacting chilled water with a ceruloplasmin-containing granule prepared from plasma, removing soluble components therefrom, separating ceruloplasmin with an anion exchange material, and precipitating the crystal of ceruloplasmin by dialysis. CONSTITUTION:Granules containing ceruloplasmin and prepared from plasma are made to contact with chilled water to remove the soluble components, and the obtained aqueous solution containing ceruloplasmin is developed by chromatography using an anion exchange material. The ceruloplasmin fraction is collected, and the aqueous solution of ceruloplasmin is dialyzed to precipitate and separate the ceruloplasmin crystal from said solution. Water-soluble protein impurities such as albumin, prealbumin, alpha1-globulin, etc. which are hardly separable by other methods can be removed by washing with chilled water. Ceruloplasmin useful as a remedy for hypoplastic anemia can be separated and purified from a raw material having low ceruloplasmin content, in high yield, by combining the above process with the subsequent purification process.
INTRODUCTION: Currently, gastroesophageal reflux disease (GERD) is the main side effect after sleeve gastrectomy (SG), causing discomfort and potential long-term risks. Surgical techniques combining fundoplication with SG are being evaluated to limit postoperative GERD.
METHODS: This single-center retrospective study evaluated patients who underwent SG with posterior fundoplication in the context of GERD between 2018 and 2021, with postoperative follow-up up to 24 months. The results were compared to a control group (ratio 1 to 4) who had SG without fundoplication. Observed total weight loss (TWL) was compared to predicted TWL using the Sophia multinational study's machine learning-based calculator.
RESULTS: The series included 22 patients (mean body mass index 44.4 kg/m2) with GERD conditions: GERD symptoms (n = 15), hiatal hernia (n = 6), esophagitis (n = 7), and Barrett's esophagus (n = 5). Two patients required reoperation, including one for valve perforation. At 2 years, GERD was present in three patients (13.6%), including two who regularly took proton pump inhibitors. Compared to the control group (n=88), the frequency of GERD persisting at 2 years was significantly reduced in the SG with fundoplication group (p=0.05). The TWL at 12 and 24 months was 27.7% and 26.1%, respectively, with no significant difference compared to the weight predicted by the model, nor compared to the control group.
CONCLUSION: The combination of posterior fundoplication with SG can be proposed in patients with GERD who have a contraindication to Roux-en-Y gastric bypass. Specific morbidity may exist at the beginning of the experience.
This study is longitudinal and observational cohort study to detect the drug resistance molecular markers in asymptomatic malaria infected local residents in study site. Only local residence who are not migrants, are recruited in the study and active and passive surveillance have been carried out within one year observation period. At the time of enrollment, blood film examination, rapid diagnosis test (RDT) testing have been done all together with the collection of the venous blood (about 1-2 mL) that would be used for molecular analysis later. All of the RDT or microscopy positive cases were treated according to the National Malaria Treatment Policy in Myanmar. A total of at least 1000 participants have been recruited in the study. Active case detection has been done in every three months. The venous blood were used for molecular based detection of the asymptomatic malaria infection by using High-throughout pooling strategy. All of the positive samples, (falciparum and vivax), have been checked for drug resistance molecular analaysis compared with the previously collected symptomatic malaria infection cases in the same region.
A system for improving the treatment of a patient's disease. A patient is fitted with a wireless motion capture device. A computer system receives the captured motion data other patient metric information and compares same to stored data sets. The stored data sets may comprise other motion data and/or metric data from the patient being examined, or captured data from other patients. The stored data sets can also be tagged with, or otherwise associated with, one or more treatment protocols. A model can be formed with respect to the patient's captured motion and other metric information. A probable treatment of the diseases, effectiveness of the patient's treatment regimen, and progression of the disease itself can be ascertained from the comparison.
The PEX11β gene contains four exons and encodes peroxisomal membrane protein 11β, which is involved in peroxisome proliferation and division. Pathogenic variants in this gene result in a rare genetic disorder with autosomal recessive inheritance called peroxisome biogenesis disorder 14B (MIM: 614920). Here, we report two affected siblings with a novel variant (NM_003846: c.11G > A, p. Trp4Ter) in the PEX11β gene that was identified by whole exome sequencing and confirmed by Sanger sequencing. The proband is a 22-year-old Iranian female who was born to consanguineous parents. The homozygous variant (NM_003846: c.11G > A, p. Trp4Ter) in the PEX11β gene was identified in the proband, who presented with cataracts, strabismus, nystagmus, intellectual disability, developmental delay, speech disorders, dry skin, and behavioral problems. Her younger affected brother, who had the same homozygous variant, suffered from similar but slightly milder symptoms. This paper reports the seventh family in the world with novel pathogenic variants in the PEX11β gene as the cause of peroxisome biogenesis disorder 14B. Additionally, the phenotypes of the previously reported patients are reviewed. Some of the phenotypes, such as bilateral congenital cataracts and intellectual disability, were present in all patients. However, other observed symptoms in previous cases, such as abnormal gait, myopia, abnormal muscle strength, hearing loss, gastrointestinal problems, skeletal disorders, and seizures, were not observed in the patients of this study. Further studies on this disorder could be valuable in determining the precise phenotype characteristics of this disease.
In recent years, systemic inflammation has emerged as a pivotal player in the development and progression of various degenerative diseases. This complex, chronic inflammatory state, often undetected, can have far-reaching consequences for the body's physiology. At the molecular level, markers such as C-reactive protein, cytokines and other inflammatory mediators serve as indicators of systemic inflammation and often act as predictors of numerous musculoskeletal diseases and even certain forms of cancer. The concept of 'meta-inflammation', specifically referring to metabolically triggered inflammation, allows healthcare professionals to understand inflammatory responses in patients with metabolic syndrome. Driven by nutrient excess and the expansion of adipose tissue, meta-inflammation is closely associated with insulin resistance, further propagating the metabolic dysfunction observed in many Western societies. Wound persistence, on the other hand, exacerbates the detrimental effects of prolonged inflammation at the local level. Acute inflammation is a beneficial and essential process for wound healing and infection control. However, when inflammation fails to resolve, it can impede the healing process, leading to chronic wounds, excessive scarring and even the activation of fibrotic pathways. This approach significantly reduces the efficacy of regenerative biological therapies. Our review focuses on the vital role of proteins, vitamins and minerals in collagen synthesis and cell proliferation for tissue healing. We also examine hormonal influences on regeneration, noting the negative effects of imbalances, and emphasize glucose regulation's importance in creating a stable environment for chronic wound healing.
Participants will be served dinner and a stable isotope of palmitate to measure fat oxidation, at a late dinner time (DLMO+1h) followed by a sleep study (DLMO+2h). This arm will cross-over to the other 2 arms in random order.
Breast cancer incidence has been steadily rising and is the leading cause of cancer death in women due to its high metastatic potential. Individual breast cancer subtypes are classified by both cell type of origin and receptor expression, namely estrogen, progesterone and human epidermal growth factor receptors (ER, PR and HER2). Recently, the importance and context-dependent role of glucocorticoid receptor (GR) expression in the natural history and prognosis of breast cancer subtypes have been uncovered. In ER-positive breast cancer, GR expression is associated with a better prognosis as a result of ER-GR crosstalk. GR appears to modulate ER-mediated gene expression resulting in decreased tumor cell proliferation and a more indolent cancer phenotype. In ER-negative breast cancer, including GR-positive triple-negative breast cancer (TNBC), GR expression enhances migration, chemotherapy resistance and cell survival. In invasive lobular carcinoma, GR function is relatively understudied, and more work is required to determine whether lobular subtypes behave similarly to their invasive ductal carcinoma counterparts. Importantly, understanding GR signaling in individual breast cancer subtypes has potential clinical implications because of the recent development of highly selective GR non-steroidal ligands, which represent a therapeutic approach for modulating GR activity systemically.
PURPOSE: A peptide which is able to specifically target apoptotic cells is provided to effectively target apoptosis and selectively transfer drug to lesion. CONSTITUTION: A polypeptide which specifically binds to apoptotic cells comprises amino acid sequence selected from sequence numbers 2, and 10 to 12. A composition for detecting apoptotic cells contains the polypeptide as an active ingredient. The polypeptide is chromogenic enzyme, isotope, chromophore, fluorescer, super paramagnetic particles, or ultrasuper paramagnetic particles. A method for detecting apoptotic cells comprises: a step of mixing the polypeptide with a sample; a step of removing polypeptides which are not bound or non-specifically bound; and a step of confirming binding of polypeptide and binding location. A composition for drug delivery contains the polypeptide as an active ingredient. The composition is effective in preventing and treating tumor diseases, stroke, myocardial infarction or the arteriosclerosis.
Spermicidal and trichomonadicidal compositions comprise a buffered pharmaceutical vehicle and from 15 to 75% by weight of the composition of an alkylphenoxypolyethoxyethanol of the general formula <FORM:0956360/A5-A6/1> in which R represents an alkyl group, R1 represents a hydrogen atom or an alkyl group and X has an average value of 5 to 12.  Optionally, there may also be present an inorganic salt, e.g. sodium or potassium chloride or sulphate, non-toxic acids (to regulate the pH), e.g. lactic, boric, acetic and tartaric acids and their salts, glycerin, propylene glycol and urea as well as conventional preservatives.  The pH of the compositions may be in the range 1 to 8.5.  The invention further comprises the combination in a package of a composition as defined above in a container and a sponge-like mass for its application and also a sponge-like mass in which is distributed a neutral salt and the above composition.
A Chinese patent medicine for treating breast cancer and a preparation method thereof belong to the field of traditional Chinese medicine. The Chinese patent medicine comprises a medicine for oral administration and a medicine for external application. The medicine for oral administration is prepared from the following raw medical materials (by weight): 20-40 parts of artemisinin, 100-200 parts of cornu cervi degelatinatum, 15-30 parts of beeswax, 50-100 parts of prepared Tielongyi and 100-200 parts of prepared tortoise plastron. The raw medical materials are mixed and crushed, and the crushed materials are sieved through a No.7 sieve so as to prepare medicinal powder, namely the finished product. The medicine for external application is prepared from the following raw medical materials (by weight): 10-20 parts of radix angelicae, 10-20 parts of rhizoma cyperi, 10-20 parts of flos caryophylli, 7.5-15 parts of bone fossil of big mammals, 7.5-15 parts of rheum officinale, 10-20 parts of radix ampelopsis, 10-20 parts of peltophorum tokinense, 5-10 parts of yellow lead and 10-20 parts of borneol. The above raw medical materials are mixed and crushed; the crushed materials are sieved through a No.7 sieve; the sieved medicinal powder is put into 80-160 milliliters of rice vinegar and uniformly stirred so as to obtain an ointment product. By simultaneously applying the medicine for oral administration and the medicine for external application, the Chinese patent medicine has advantages of short treatment course, high curative effect, low treatment fee, less pain for patients and simple preparation method.