anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To compare hip survivorship and patient-reported outcomes after primary hip arthroscopy for femoroacetabular impingement syndrome (FAIS) in patients with versus without comorbid borderline hip dysplasia (BHD) at 2-year follow-up.
METHODS: A retrospective matched-cohort study was conducted involving patients who underwent primary hip arthroscopy for FAIS with a single surgeon from 2010 to 2019. BHD was defined as lateral center edge angle (LCEA) of 20 to 25°. Subjects with BHD were matched 1:2 to controls without BHD on age, sex, body mass index, and preoperative modified Harris Hip Score (mHHS). Alpha angle, LCEA, Tönnis angle, and acetabular retroversion signs were measured on preoperative and/or postoperative hip radiographs. Patient-reported outcomes were assessed using the mHHS and the Non-Arthritic Hip Score. Hip survivorship, outcome scores, and achievement of the minimum clinically important difference were compared between groups using the Mann-Whitney U test or Fisher exact test, as appropriate. P values <.05 were considered significant.
RESULTS: Thirty-one BHD subjects (mean age 36.8 years, 71.0% female) and 62 controls (mean age 38.0 years, 71.0% female) were included. There were no significant intergroup differences in demographics or preoperative radiographic measurements besides LCEA and Tönnis angle (all P > .05). Intraoperatively, subjects with BHD were found to have significantly shorter labral tears (mean 2.6 vs 2.8 clock-face hours, P = .048), but there were no significant intergroup differences in acetabular or femoral cartilage status (all P > .05). Postoperatively, there were no significant intergroup differences in rates of revision arthroscopy (BHD 6.5% vs control 11.3%) or conversion to total hip arthroplasty (BHD 9.7% vs control 1.6%), in 2-year improvement of the mHHS and Non-Arthritic Hip Score, or in minimum clinically important difference achievement rates (all P > .05).
CONCLUSIONS: BHD is not associated with a significant difference in hip survivorship or patient-reported outcomes following primary hip arthroscopy for FAIS.
LEVEL OF EVIDENCE: Level III, retrospective comparative study.
BACKGROUND: Anastomotic strictures following colectomy and proctectomy are a significant cause of benign lower gastrointestinal tract (LGIT) obstruction, with a reported incidence of up to 30%. Endoscopic interventions such as balloon dilation, stricturotomy, mechanical dilation, electrocautery incision, and stent placement are utilized for management. This meta-analysis aimed to evaluate the efficacy and safety of endoscopic interventions for the management of benign LGIT anastomotic strictures.
METHODS: Literature search was performed for published full-text articles using the Embase, Pubmed, Web of Sciences, and Cochrane databases for endoscopic management of anastomosis strictures and related terms including endoscopic balloon dilation (EBD), stricturotomy (EST), mechanical dilation, electrocautery incision (ECI), and stent placement.
RESULTS: A total of 1363 patients from 33 studies were included. The most common indication for anastomosis was colorectal cancer (92%). Overall technical success (ability to pass the endoscope) was achieved in 93% of cases, with immediate clinical success in 85% and sustained success in 81% at follow-up. ECI demonstrated the highest clinical success rates (98% immediate, 91% at the end of follow-up). Adverse events occurred in 6% of patients, most commonly perforation, which was most frequent with EBD. Stent placement showed high initial success but had issues with stent migration and adverse events.
CONCLUSION: Overall, EBD and ECI were the most effective, with ECI showing the highest success rates. Despite its technical challenges, EST was both effective and safe. This study underscores the need for further prospective research comparing various endoscopic interventions to improve management strategies for LGIT anastomotic strictures.
The procedure consists of heating the drupes in controlled conditions which avoid oxidation of the natural anti-oxidants in the pulp, rapid or quasi-instantaneous evaporation of part of the water contained in the pulp to promote destructuring of the pulp cells and starting the separation of the pulp from the skin and stone. The procedure consists of heating or pre-heating the drupes in controlled conditions which avoid oxidation of the natural anti-oxidants in the pulp, rapid or quasi-instantaneous evaporation of part of the water contained in the pulp to promote destructuring of the pulp cells and starting the separation of the pulp from the skin and stone. This is followed by physical separation of part of the pulp from the stones and skin and recuperation of the destructured pulp to yield oil and a puree. The initial heating takes place in a chamber (20) with microwave heaters (24, 26), followed by a buffer chamber (30) and evaporation chamber (40) with a system (52) for physical separation of part of the pulp. The separated pulp then passes to oil separators and recuperators (160, 170, 172, 174). Other systems separate the skins and stones and press oil from the kernels.
In order to overcome the defects in the prior art, the invention provides a preparation method of an oil-soluble natural pigment. The method comprises the following steps: S1. mixing a natural pigment raw material with an oil-soluble antioxidant and an emulsifier B with the HLB (hydrophile-lipophile balance) value of 8-18 to obtain a pretreatment solution; S2. adding an emulsifier A with the HLB value of 2-7 into the pretreatment solution obtained in the step S1, and mixing and stirring to obtain an emulsion; and S3. carrying out homogenization treatment on the emulsion obtained in the step S2 to obtain the oil-soluble natural pigment. The homogenization treatment process comprises the following steps: putting the emulsion obtained in the step S2 into a high-pressure homogenizer at 20-60 DEG C under the pressure of 10-50 MPa, and carrying out homogenization treatment for 0.3-5 hours. The oil-soluble natural pigment has the advantages of short process route, low equipment cost and low operating cost. The obtained product can be widely used in the fields of food, medicine, cosmetics and the like. The oil-soluble natural pigment has favorable oil solubility and stability. The preparation method can be used for preparing oil-soluble gardenia blue.
An algorithm of QRS detection capable of reducing noise effects includes steps of adjustment, reading, pre-processing, transformation, calculation and selection. The adjustment step is to adjust panes before reading an original signal in the reading step in order to capture the original signal via the panes. The pre-processing step is to remove baseline drift and the transformation step is to execute the wavelet transformation in order to obtain high and low frequency signals of all scales. Further, the calculation step is to calculate positive and negative threshold values. Finally, the selection step is to select a scale for analyzing based on the amount of the noise. Therefore, the algorithm can judge the amount of the noise in the signal effectively and reduce effects caused by the noise via selecting the scale with fewer noise, thereby weakening the noise effects affecting the QRS detection, increasing the judgment accuracy greatly, reducing the calculation to speedily assess and diagnose diseases and decrease the consumption of human resource.
An estimated 17 million Americans are living with cancer, and the majority receive chemotherapy annually, which, in addition to common side effects like pain, fatigue, nausea, vomiting, and hair loss, also imposes a significant psychological and emotional toll on patients. Studies consistently show a high prevalence of depression and anxiety among cancer patients due to both the disease and the therapeutic burden, with prolonged chemotherapy being a particularly significant risk factor. This underscores the need for nonpharmacological and non-invasive treatments to reduce the negative emotional states, psychological burden, and stress that often accompany chemotherapy. Music therapy has increasingly been utilized in clinical settings as a complementary intervention, benefiting various populations, including those with dementia-related disorders, by treating cognitive and behavioral symptoms through social interaction and other acute benefits. Passive music therapy, such as listening to recorded or live music, has been shown to ease psychosocial symptoms, even in the absence of a trained music therapist. Overall, music therapy promotes wellness, manages stress, alleviates pain, enhances memory, improves communication, and supports physical rehabilitation. For instance, in hypertensive young adults, four weeks of passive music therapy significantly lowered systolic blood pressure and heart rate, suggesting a soothing and rehabilitative effect. Additionally, singing along to music boosts cytokine levels, indicating strengthened immunity through improved mood and reduced stress. Music therapy research supports its benefits for cancer patients, as studies have shown improved mood, reduced distress, increased resilience, and decreased anxiety and heart rate during chemotherapy. Despite these demonstrated benefits, music therapy services are under-resourced, particularly in Rhode Island, where only one licensed music therapist was reported in 2020, serving around 2000 clients across eight facilities. This project aims to implement a music therapy program at Miriam Hospital to enhance the well-being of chemotherapy patients and potentially expand to other Lifespan Infusion Centers in Rhode Island, such as Rhode Island Hospital and Newport Hospital. Given the lack of structured music therapy programs for oncology patients in Rhode Island, this initiative seeks to establish a formal music therapy offering at Miriam Hospital, setting the stage for broader adoption and integration of music therapy in cancer care across the state.
AIM: To identify the features of plasma, platelet hemostasis, and proteomic composition of the blood plasma in patients with acute myocardial infarction (AMI) and healthy volunteers after COVID-19.
MATERIAL AND METHODS: The study included patients with AMI who have recently had COVID-19 (AMI-post-COVID, n=56) and patients with AMI who have not recently had COVID-19 (AMI-control, n=141). Healthy volunteers constituted the control groups and were also divided into control-post-COVID (n=32) and control-control (n=71) groups. Previous SARS-CoV-2 infection was determined by anti-N IgG in the blood serum, the level of which persists for 6-10 months after the disease. Hemostasis was evaluated by thromboelastometry (on whole blood), thrombodynamics (on platelet-poor plasma), fibrinolysis, impedance aggregometry, and proteomic analysis.
RESULTS: The AMI-post-COVID and AMI-control groups had higher values of thrombus growth rate, size and density based on the data of thromboelastometry and thrombodynamics, as well as increased concentrations of the complement system components, proteins regulating the state of the endothelium, and a number of acute-phase and procoagulant proteins compared to the control groups. Furthermore, in the AMI-post-COVID group, compared to the AMI-control group, the thrombus density was lower, and its lysis rates were higher when measured by the thrombodynamics method on platelet-poor plasma, while the platelet aggregation induced by ADP and thrombin was higher. Also, in the control-post-COVID group, compared to the control-control group, the thrombus formation rate was lower, whereas, in contrast, the thrombus size as measured by the thrombodynamics method and the platelet aggregation induced by arachidonic acid and thrombin were higher. In addition, in the AMI-post-COVID group, compared to the AMI-control group, the concentrations of proteins involved in inflammation and hemostasis were lower.
CONCLUSION: Patients with AMI who have recently had COVID-19 are characterized by a less pronounced activation of the immune response compared to patients with AMI who have not had COVID-19. This may be due to long-term chronic inflammation and depletion of components of the immune activation system after SARS-CoV-2 infection. Long-term activation of the hemostasis system in both patients with AMI and healthy volunteers after COVID-19 is primarily due to the platelet component of hemostasis.
Beyond tremor, ET patients display a wide spectrum of clinical abnormalities such as ataxia, deafness, olfactory disturbances, cognitive dysfunction and personality changes. Cognitive dysfunction mainly consists in a dysexecutive syndrome. Personality changes are characterized by increased harm avoidance. These findings suggest a complex modification in frontal lobe function in ET patients, including aspects of dorsolateral and orbitofrontal control. Previous studies have exclusively focused on dorsolateral prefrontal control, while orbitofrontal aspects remain to be elucidated. Orbitofrontal areas are involved in processing emotion and reward, as well as normal social behavior. Dysfunction in these regions may have direct consequences in daily social life.

We hypothesize that decision-making and facial emotion recognition are impaired in ET patients due to frontal lobe dysfunction which may have consequences in daily social life. The first aspect can be assessed with the Iowa Gambling Task, a simple paradigm that simulates real-life decision-making. Briefly, players are given four decks of cards, a loan of $ 2,000 and asked to play so they can lose the least amount of money and win the most. Turning each card carries an immediate reward and sometimes an unpredictable penalty. Decks A and B are the most disadvantageous leading to an overall loss of money, while decks C and D are the most advantageous with an overall gain of money. In contrast to control subjects, patients with damage of the orbitofrontal or ventromedian cortex continue to perseverate with the bad decks, sometimes even though they know that they are losing money overall. The second aspect, i.e. the recognition of facial emotion can be assessed in a simple paradigm where patients have to choose the best fitting response among six facial expressions (happiness, sadness, fear, surprise, disgust and anger) that are presented in random order. All study subjects will be tested with the Benton Visual Retention Test to exclude impairment in visual perception, visual memory or visuoconstructive abilities.

Performances in the Iowa Gambling Task and the facial emotion recognition test will be compared between ET patients and controls. All study subjects will also be tested with the following battery: Modified Card Sorting Test, Stroop, Trail Making Test and Verbal Fluency, Beck Depression Inventory and the Mattis Dementia Rating Scale. These tests will allow assessing the impact of executive function, depression and memory loss on performances in the Iowa Gambling Task and the facial emotion recognition test. Finally, performances in the Iowa Gambling Task and the facial emotion recognition test will be related to sex, age, disease duration and tremor severity.
The most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding (3,4). Cathflo Activase has not been studied in patients known to be at risk for bleeding events that may be associated with the use of thrombolytics. Caution should be exercised with patients who have active internal bleeding or who have had any of the following within 48 hours: surgery, obstetrical delivery, percutaneous biopsy of viscera or deep tissues, or puncture of non‑compressible vessels. In addition, caution should be exercised with patients who have thrombocytopenia, other hemostatic defects (including those secondary to severe hepatic or renal disease), or any condition for which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location, or who are at high risk for embolic complications (e.g., venous thrombosis in the region of the catheter). Death and permanent disability have been reported in patients who have experienced stroke and other serious bleeding episodes when receiving pharmacologic doses of a thrombolytic.

Should serious bleeding in a critical location (e.g., intracranial, gastrointestinal, retroperitoneal, pericardial) occur, treatment with Cathflo Activase should be stopped and the drug should be withdrawn from the catheter.
The CASK gene and its product protein kinase have been associated with microcephaly with pontine and cerebellar hypoplasia (MICPCH) syndrome and various other neurodevelopmental disorders. Clinical presentation is highly variable and generally includes intellectual disability, neurological disorders, and dysmorphic features, at a minimum. We present the case of one of the oldest known currently living patients with MICPCH syndrome with additional features not previously described in the literature (midface retrusion, macroglossia, dental crowding, adolescent-onset contractures at large joints, laxity at finger joints, and prominent wrist dystonia). Progressive hypertonicity throughout the patient's life has been managed with serial botulinum toxin injections. A comprehensive multimodal care team including physiatry, physical therapy, exercise therapy, and audiology has been assisting her with hearing deficits, communication skills, and mobility. This potentially expands the phenotype of MICPCH syndrome and provides information about the management of this condition into adulthood.
PURPOSE: To save measured organism signals as organism data individually and to precisely reproduce the organism signals after measuring them by detachably forming a second memory means, a second transmitting means, and a second display means integrally in a vital reaction measuring device main body. CONSTITUTION: When integrally formed second memory means M6, second transmitting means M8, and second display means M9 are attached to this vital reaction measuring device main body, a first transmitting means M7 reads organism information out of a first memory means M3, and transmits the data to the second memory means M6. Then, as recognition data on organism tissues are previously stored in the second memory means M6, the organism information is maintained by each organism tissue. After that, the second memory means M6, the second transmitting means M8, and the second display means M9 are detached from the vital reaction measuring device main body, and they are kept separately.  Next, when these means are attached to the organism vital reaction measuring device again, the second display means M9 reads the recognition data on organism tissues out the second memory means M6 and displays the data. Then the second transmitting means M8 reads the organism information stored in the second memory means M6 and transmits the data to the first memory means M3.
An improved process for the extraction of  pygeum  from the plant of the family rosacaea, amygdales tribe, genus  Prunus  species  domestica  ( Indian Prunus ) and related species (as herein defined) comprising the steps of collecting the plant material i.e. stem cuttings/twigs, removing the leaves and drying till moisture content is about 10-15%, powdering the stem material, extracting with chlorinated organic solvents and water-alcohol mixture, in ratio of 1:4, filtering and drying the extract under vacuum at 30 degree Celsius to obtain a greenish mass with bitter almond smell, the mass being referred to as ‘ pygeum ’ wherein in the improved process, a ‘renewable plant source’ i.e. stem cuttings/twigs, are used for extraction of  pygeum  instead of a ‘non-renewable’ source such as bark of the tree. The  pygeum  obtained by the new process has a pharmacopeia profile similar to the product ‘ pygeum ’ obtained from a ‘non-renewable source’ i.e. bark of  Pygeum africanum . Further, it is non-toxic and shows anti-BPH (benign prostatic hyperplasia) activity comparable with that of  pygeum  obtained from non-renewable source i.e. bark of  Prunus africana.
BACKGROUND: A global public health problem, frailty is closely associated with poor prognosis after percutaneous coronary intervention (PCI) in older patients with acute myocardial infarction (AMI). Although exercise intervention is the most commonly used method to reverse and alleviate frailty, its application is restricted in patients with acute myocardial infarction following PCI due to cardiovascular instability and autonomic imbalance. Consequently, there is a need for a new practical intervention to address frailty syndrome in these patients.
PURPOSE: This study aimed to investigate the effect of neuromuscular electrical stimulation in frail older AMI patients post-PCI.
PATIENTS AND METHODS: A single-blind, randomized controlled trial was carried out in the Department of Cardiovascular Medicine from March to October 2023. A total of 100 eligible participants were randomly divided into two groups: experimental (n = 50) and control (n = 50) groups, respectively. Both groups received usual care. The experimental group underwent neuromuscular electrical stimulation (NMES) on bilateral quadriceps and gastrocnemius muscles for 30 minutes daily from day 1 to day 7 after surgery. The primary outcomes measured included the frailty score, lower limb muscle strength, and lower limb muscle quality. Secondary outcomes included the activities of daily living score, inflammatory markers, and length of hospital stay. All participants were included in an intention-to-treat analysis after the study ended.
RESULTS: The frailty scores of the two groups exhibited a gradual decrease over time, and the scores of the experimental group were lower than those of the control group at 4 and 7 days after surgery (P<0.001). Concurrently, the lower limb muscle strength showed an increasing trend over the time in the experimental group and a decreasing trend in the control group, and the scores of the experimental group surpassed those of the control group (p<0.001). Moreover, a statistical difference was observed in the lower limb muscle mass across the groups after 7 days postoperatively compared with baseline on both sides (p<0.05).
CONCLUSION: Neuromuscular electrical stimulation has the potential to enhance lower limb function and alleviate frailty in elderly patients with acute myocardial infarction after PCI. These findings introduce a novel intervention approach for frailty management in the elderly population.
<P>PROBLEM TO BE SOLVED: To provide a compound controlling activity of the CXC chemokine receptor.  <P>SOLUTION: There is disclosed a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof which is useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer. There is also provided a pharmaceutical composition comprising the compound represented by formula (I) in combination with a pharmaceutically acceptable carrier or diluent or both. Further a method is provided for treating α-chemokine-mediated diseases in mammal. The method comprises a step of administering an effective amount of compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof to a patient in need of such treatment.  <P>COPYRIGHT: (C)2009,JPO&INPIT