anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Sigmoid gallstone ileus is a rare complication of cholelithiasis, accounting for 1-4% of all cases of large-bowel obstruction. This is a highly morbid, and often fatal, condition due to its challenging diagnosis and late presentation.
CASE PRESENTATION: We report a case of a 90-year-old woman admitted to Emergency Department with abdominal pain and large-bowel obstruction due to a 6 cm gallstone lodged in a diverticulum of the proximal sigmoid colon as a consequence of a cholecysto-colonic fistula. Colonoscopy was deferred due to gallstone size carrying a high possibility of failure. The patient underwent urgent laparotomy with gallstone removal via colotomy. The cholecystocolonic fistula was left untreated. The post-operative course was uneventful; the patient was discharged on 6th post-operative day.
CONCLUSION: A multidisciplinary discussion between endoscopists and surgeons is often needed to choose the best therapeutic option, especially in high-risk patients.
The IgG1b12 human monoclonal antibody binds gp120 strongly, and is the most potent HIV neutralizing antibody known. The exact amino acid sequence of this binding site is not known. We identified the minimal terminal peptide parts of the HIV-1 gp120 (envelope) protein, which IgG1b12 binds to. We did this by quadrupole time of flight (QqTOF) mass spectrometry using epitope excision. Epitope excision allows for determination of conformational epitopes. To do this we bound gp120 to IgG1b12, digested off all unbound portions of gp120, and then ran mass spectrometry of the resulting IgG1b12-gp120 peptide complex. The results allow us to determine the exact amino acid sequence involved in IgG1b12-gp120 interaction.
In flowering plants, male gametes are immotile and carried by dry pollen grains to the female organ. Dehydrated pollen is thought to withstand abiotic stress when grains are dispersed from the anther to the pistil, after which sperm cells are delivered via pollen tube growth for fertilization and seed set. Yet, the underlying molecular changes accompanying dehydration and the impact on pollen development are poorly understood. To gain a systems perspective, we analyzed published transcriptomes and proteomes of developing Arabidopsis thaliana pollen. Waves of transcripts are evident as microspores develop to bicellular, tricellular, and mature pollen. Between the "early"- and "late"-pollen-expressed genes, an unrecognized cluster of transcripts accumulated, including those encoding late-embryogenesis abundant (LEA), desiccation-related protein, transporters, lipid-droplet associated proteins, pectin modifiers, cysteine-rich proteins, and mRNA-binding proteins. Results suggest dehydration onset initiates after bicellular pollen is formed. Proteins accumulating in mature pollen like ribosomal proteins, initiation factors, and chaperones are likely components of mRNA-protein condensates resembling "stress" granules. Our analysis has revealed many new transcripts and proteins that accompany dehydration in developing pollen. Together with published functional studies, our results point to multiple processes, including (1) protect developing pollen from hyperosmotic stress, (2) remodel the endomembrane system and walls, (3) maintain energy metabolism, (4) stabilize presynthesized mRNA and proteins in condensates of dry pollen, and (5) equip pollen for compatibility determination at the stigma and for recovery at rehydration. These findings offer novel models and molecular candidates to further determine the mechanistic basis of dehydration and desiccation tolerance in plants.
A device supported by a user while the user is in locomotion on foot during an outing may monitor a performance parameter of the user. The performance parameter may comprise a pace and/or a speed of the user. Prior to the outing, the device may be configured to specify a first interval and second interval, corresponding to a first and second performance zone, respectively, for the outing. Each performance zone may be different from one another and each zone may comprise one of a zone of paces and a zone of speeds. During the first interval, an action may be taken with the device in response to determining that the monitored performance parameter has fallen outside of the first performance zone. During the second interval, an action may be taken with the device in response to determining that the monitored performance parameter has fallen outside the second performance zone.
This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.  
Sodium Chloride Injection, USP, 23.4% is hypertonic and must be diluted prior to administration. Inadvertent direct injection or absorption of concentrated sodium chloride solution may give rise to sudden hypernatremia and such complications as cardiovascular shock, central nervous system disorders, extensive hemolysis and cortical necrosis of the kidneys.
BACKGROUND: Erector spinae plane (ESP) block spread can be unpredictable. We previously improved the spread of ESP injection by addition of retrolaminar (RL) injection. However, it is not clear whether spread at high thoracic levels is similar to spread at midthoracic levels. Our primary objective was to demonstrate that craniocaudal dye spread was equivalent after combined ESP and RL injection using a 19 G Tuohy needle at the third (T3) and sixth (T6) vertebrae in soft embalmed Thiel cadavers.
METHODS: We randomised 20 combined ESP and RL injections to the T3 and T6 vertebral levels on both sides of 10 prone Thiel cadavers. A 3-8 MHz transducer was placed in the paramedian sagittal plane and a single anaesthetist injected 10 ml dye onto the transverse process, then 10 ml dye onto the laminae of T3 or T6. Cadavers were dissected 24 h later.
RESULTS: Mean (sd) craniocaudal spread of dye after combined ESP + RL injection at T3 and T6 vertebral levels was equivalent: 8.6 (1.8) vs 8.7 (2.3) levels, respectively; difference (90% confidence interval): -0.1 (-1.4 to 1.6), P=0.904. Dye extended uniformly, cranially and caudally, from the point of injection. A 3D prosection created from a Thiel cadaver confirmed that the dorsal ramus emerges from the costotransverse foramen deep to the intertransverse ligament within the retro-superior costotransverse ligament space. Combined ESP and RL block in six patients before mastectomy achieved extensive anterior, lateral, and posterior chest wall paraesthesia over four to six dermatomes.
CONCLUSIONS: Combined ESP and RL injections showed equivalent and consistent spread at T3 and T6 injection sites. A pilot study confirmed translation to patients.
Patients that are part of the UW LUTD Program (n=30) will undergo 3 weekly biofeedback sessions each lasting 1 hour. All interactive biofeedback sessions will be conducted by American Family Children's Hospital nurses that are experienced in standard biofeedback techniques. After the patient has completed all of the biofeedback sessions, he/she will complete a feedback form about their satisfaction with the device.
ETHNOPHARMACOLOGICAL RELEVANCE: Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese poly-herbal formulation, has been validated in clinical trials to mitigate cardiac remodeling (CR), and cardiac damage in patients with hypertension. However, the specific mechanism remains unclear.
AIM OF THE STUDY: This study explored the potential effects and potential mechanisms of QYYYG on hypertensive CR by combining various experimental approaches.
MATERIALS AND METHODS: Spontaneously hypertensive rats (SHRs) were used as a model of hypertensive CR, followed by QYYYG interventions. Blood pressure, cardiac function and structure, histopathological changes, and myocardial inflammation and oxidative stress were tested to assess the efficacy of QYYYG in SHRs. For in vitro experiments, a cell model of myocardial hypertrophy and injury was constructed with isoprenaline. Cardiomyocyte hypertrophy, oxidative stress, and death were examined after treatment with different concentrations of QYYYG, and transcriptomics analyses were performed to explore the underlying mechanism. Nrf2 and the ROS/NF-κB/NLRP3 inflammasome pathway were detected. Thereafter, ML385 and siRNAs were used to inhibit Nrf2 in cardiomyocytes, so as to verify whether QYYYG negatively regulates the NLRP3 inflammasome by targeting Nrf2, thereby ameliorating the associated phenotypes. Finally, high performance liquid chromatography (HPLC) was conducted to analyze the active ingredients in QYYYG, and molecular docking was utilized to preliminarily screen the compounds with modulatory effects on Nrf2 activities.
RESULTS: QYYYG improved blood pressure, cardiac function, and structural remodeling and attenuated myocardial inflammation, oxidative stress, and cell death in SHRs. The transcriptomics results showed that the inflammatory response might be crucial in pathological CR and that Nrf2, which potentially negatively regulates the process, was upregulated by QYYYG treatment. Furthermore, QYYYG indeed facilitated Nrf2 activation and negatively regulated the ROS/NF-κB/NLRP3 inflammasome pathway, therefore ameliorating the associated phenotypes. In vitro inhibition or knockdown of Nrf2 weakened or even reversed the repressive effect of QYYYG on ISO-induced inflammation, oxidative stress, pyroptosis, and the NLRP3 inflammasome activation. Based on the results of HPLC and molecular docking, 30 compounds, including cafestol, genistein, hesperetin, and formononetin, have binding sites to Keap1-Nrf2 protein and might affect the activity or stability of Nrf2.
CONCLUSION: In conclusion, the alleviatory effect of QYYYG on hypertensive CR is related to its regulation of Nrf2 activation. Specifically, QYYYG blocks the activation of the NLRP3 inflammasome by boosting Nrf2 signaling and depressing myocardial inflammation, oxidative stress, and pyroptosis, thereby effectively ameliorating hypertensive CR.
Novel compounds useful as renin inhibitors are provided. The compounds are hydroxyazido derivatives having structural formula (1), wherein the substituents R1? through R7? are as defined herein. Analogs of these compounds which are ketoazido derivatives are also provided. Additionally disclosed are methods for using the novel compounds to treat hypertension, and pharmaceutical compositions containing the compounds. Of particular interest are formulations for oral administration.
The invention provides a foot bath formula for treating insomnia. The foot bath is prepared from, by weight, ramulus uncariae cum uncis, stems of miscanthus floridulus(Labill.)Warb., leaves of melia azedarach L., roots of pterospermum heterophyllum Hance., herba pyrolae, rhizoma pinelliae preparatum, raw dragon's teeth, fresh rhizoma imperatae, caulis bambusae in taenia, radix rhapontici, indigo naturalis, fructus viticis, herba taxilli, herba artemisiae scopariae, valerian roots, herba lophatheri, rhizoma acori tatarinowii, concha margaritifera, herba siegesbeckiae, herb of swertia punicea Hemsl. and folium artemisiae argyi water. According to the foot bath formula, ramulus uncariae cum uncis, stems of miscanthus floridulus(Labill.)Warb., leaves of melia azedarach L., roots of pterospermum heterophyllum Hance., herba pyrolae, rhizoma pinelliae preparatum and raw dragon's teeth serve as the main raw materials, fresh rhizoma imperatae, caulis bambusae in taenia, radix rhapontici, indigo naturalis, fructus viticis, herba taxilli, herba artemisiae scopariae, valerian roots, herba lophatheri, rhizoma acori tatarinowii, concha margaritifera, herba siegesbeckiae and herb of swertia punicea Hemsl. are added by taking the folium artemisiae argyi water as the basis, and therefore the foot bath has the function of dredging and activating collaterals, effectively improves sleep, promotes metabolism, increases blood circulation and strengthens the basic physical fitness of human bodies.
A ridgidly spaced, cyclodextrin dimers having a preselected breaking point within the spacer sequence so as to controllably release the active pharmaceutically active substance only after it reaches the desired treatment site is described. These preselected breaking points are stable in blood but are cleavable within cells. In preferred embodiments, the cyclodextrin-pharmaceutically active substance complex is targeted to specific sites via incorporation of specific antibodies for the targeted sites, typically by complexing a biotin-avidin system to specific antibodies which thereby targets the complex to a specific site. Once at the site as the complex is taken up into the cell the preselected break point is cleaved and the encapsulated pharmaceutically active substance becomes available for action within the targeted cell. This approach permits the use of highly effective and efficient pharmaceutically active substances, whose safety restricts use to last chance efforts or which are unable to qualify for human use due to their potential side effects. In a preferred embodiment peptide structures are used as part of the spacers between bridged cyclodextrins. The cyclodextrin oligomers are complexed with pharmaceuticals with potential high side effects to safely, efficiently achieve the therapeutic action desired.
Partial responders were not randomized. Subjects who were partial responders at Week 52 visit in core studies (e.g.CAIN457A2302 or CAIN457A2303) and have been on secukinumab s.c. 150 mg or 300 mg in core studies did not participate in the randomized withdrawal. These subjects continued same treatment s.c. dose in PFS (secukinumab s.c. 150 mg or 300 mg) as they were receiving at the time of completing the maintenance period (Week 52) in the core studies.
BACKGROUND: There is little information about the effect of single nucleotide polymorphisms (SNP) and nutritional status and weight loss after bariatric surgery. This study investigated the interactive effect of eight obesity-related SNPs and nutritional status on weight loss after Roux-en-Y gastric bypass (RYGB).
METHOD: This is a case-control study. After 1-year follow-up, the patients who underwent RYGB were dividing into two groups. The case group consisted of patients who lost more than 50% of their excess body weight (EBW%) 1 year after the surgery. The control group included patients who lost < 50% of EBW at same time frame. Then, the relationship between eight SNPs related to UCP2, FTO, LEPR, GHRL, and NPY genes with weight loss were checked.
RESULTS: In this study, 160 patients were recruited. The median of age for case and control group were 43 and 42 respectively. The presence of mutant variant NPYrs16147 had a significant relationship in terms of weight loss between the two groups (P > 0.05). In dominant model, two SNPs, UCP2 rs659366 and UCP2 rs660339, showed protective effect of the vitamin D deficiency.
CONCLUSION: In conclusion, the presence mutant variant of NPYrs16147 is directly related to the incidence of weight loss greater than 50% of EBW. However, it is apparent individual behavioral, dietary, and other factors may have more influence on weight loss among patients underwent RYGB.
Hobbes' Leviathan symbolizes state sovereignty. In public health, this concept now extends to the prevention and promotion of health and the fight against non-communicable diseases (NCDs). This article explores the evolution towards an i-Leviathan, utilizing health data for more effective health surveillance. Precision public health, grounded in a personalized law approach, relies on the collection, availability, and use of these health data. This article analyzes the legal challenges of this precision, such as stigmatization, discrimination, and repression. It addresses the balance between public interests and individual freedoms, outlining state measures to monitor, control, and discipline healthy individuals.
The medical image-processing apparatus that embodiments of the present invention provide can carry out stereopsis to multiple comparison other things rightly in same frame. Medical image-processing apparatus in one embodiment of the present invention, has image obtaining section, three-dimensional medical imaging generating unit, update information obtaining section, angles of display correction portion and display part. Image obtaining section obtains the medical image data that comprises object. Three-dimensional medical imaging generating unit generates the three-dimensional medical image data of the energy stereopsis that comprises multiple objects according to the medical image data of being obtained by image obtaining section. Update information obtaining section obtains the update information in multiple objects. Angles of display correction portion according to update information to revise the three-dimensional medical image data of mode correction of angles of display of at least one object. Display part shows the three-dimensional medical imaging of the three-dimensional medical image data based on by the correction of angles of display correction portion.
New colloid solution suitable for use as a blood substitute is obtainable by reaction of a physiologically tolerable, water soluble colloid with an aliphatic perfluoro cpd. and adjustment to an isotonic electrolyte content. Used as a substitute for blood or plasma for transfusions when high blood losses have to be replaced. Thon osmotic and cotic pressure and flow properties of the colloid solution are closely similar to those of blood. The solution caters for transport and exchange of, but does not react with, oxygen and CO2. It has no adverse effects on the constituents of natural blood, and facilitates the regeneration of blood components. The components of the solution are eventually excreted from the body.
Dexmedetomidine 100 mcg/mL (concentration of 200 mcg/2 mL) will be atomized for intranasal administration at a dose of 4 mcg/kg (0.04 mL/kg) according to a weight-based dosing chart. The maximum dose will be 200 mcg.
PURPOSE OF THE REVIEW: To summarize currently available data on the topic of mitral valve prolapse (MVP) and its correlation to the occurrence of atrial and ventricular arrhythmias. To assess the prognostic value of several diagnostic methods such as transthoracic echocardiography, transesophageal echocardiography, cardiac magnetic resonance, cardiac computed tomography, electrocardiography, and electrophysiology concerning arrhythmic episodes. To explore intra and extracellular biochemistry of the cardiovascular system and its biomarkers as diagnostic tools to predict rhythm disturbances in the MVP population.
RECENT FINDINGS: MVP is a common and mainly benign valvular disorder. It affects 2-3% of the general population. MVP is a heterogeneous and highly variable phenomenon with three structural phenotypes: myxomatous degeneration, fibroelastic deficiency, and forme fruste. Exercise intolerance, supraventricular tachycardia, and chest discomfort are the symptoms that are often paired with psychosomatic components. Though MVP is thought to be benign, the association between isolated MVP without mitral regurgitation (MR) or left ventricle dysfunction, with ventricular arrhythmia (VA) and sudden cardiac death (SCD) has been observed. The incidence of SCD in the MVP population is around 0.6% per year, which is 6 times higher than the occurrence of SCD in the general population. Often asymptomatic MVP population poses a challenge to screen for VA and prevent SCD. Therefore, it is crucial to carefully assess the risk of VA and SCD in patients with MVP with the use of various tools such as diagnostic imaging and biochemical and genetic screening.
The prelimbic cortex (PL) is actively engaged in pain modulation. The infralimbic cortex (IL) has been reported to regulate the PL. However, how this regulation affects pain remains unclear. In the present study, we recorded temporary hyper-activity of PL pyramidal neurons responding to nociceptive stimuli, but a temporary hypo-function of the IL by in vivo electrophysiological recording in rats with peripheral inflammation. Manipulation of the PL or IL had opposite effects on thermal hyperalgesia. Furthermore, the functional connectivity and chemogenetic regulation between the subregions indicated an inhibitory influence of the IL on the PL. Activation of the pathway from the IL to the PL alleviated thermal hyperalgesia, whereas its inhibition exacerbated chronic pain. Overall, our results suggest a new mechanism underlying the role of the medial prefrontal cortex in chronic pain: hypo-function of the IL leads to hyperactivity of the PL, which regulates thermal hyperalgesia, and thus contributes to the chronicity of pain.
Cosmetic composition comprising a filler, a greasy binder and at least 2 % by weight on total weight of the composition of at least one nanopigment such that (i) the pigment volume concentration of the combination of nanopigments and fillers is less than or equal to the critical pigment volume concentration and (ii) the volume of fillers Vc is greater than or equal to twice the volume of the nanopigments Vn. Preferably the nanopigments are chosen from metal oxides such as Fe2O3, TiO2, ZnO, Bi oxychloride, CrO3, etc. The nanoparticles are e.g. generally spherical, with an average size of 0.01-0.15 microns, or non- spherical with a largest dimension of 0.15 microns. The fillers are selected e.g. from talc, silica, mica, boron nitride, polyamide powder, silicone powder or polymethyl methacrylate powder, and preferably have a particle size of ≥ 10 microns. Preferably the composition contains 2-30 wt. % of the mixture of nanopigments and fillers. Preferably the system of fillers + nanopigments satisfies the relationship (pigment volume concentration) ≤ (critical pigment volume concentration)/2.
The GRP78 binding peptide (anti-GRP78 peptide) is labeled radioisotope for detecting colorectal cancer. The process include providing the GRP78 receptor binding peptides; getting the radiolabeling substance; and injecting the radiolabeling substance into vein in human or animals. Then, the microSPECT/CT and microPET/CT are used for imaging the colorectal cancer. The nuclear imaging can express the size and distribution of tumor, and identify the stage of cancer by counting the shading value of imaging. In clinical, it will be safe, noninvasive, and accurate to detect the development degree of colorectal cancer. Moreover, the technique can apply to diagnose the colorectal cancer and trace after treatment to achieve the ideal of preventive medicine for diagnosis and treatment early.
Patients receive oral placebo once daily. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
The invention discloses an MICA extracellular domain mutant and a screening method thereof, a scFv-MICA fusion antibody and a preparation method and application thereof. The MICA extracellular domain mutant is mutated at positions 24, 33, 69, 112, 126. The screening method comprises the following steps: constructing a mutant MICA phage library, expressing the recombinant protein NKG2D-Fc, phage screening and the like. The scFv-MICA fusion antibody is linked by scFv to MICA mutant with flexible peptide. The preparation method comprises the following steps: constructing recombinant genes of the fusion antibody; constructing a recombinant vector; transfecting competent cells, expressing and purifying, and the like. The MICA extracellular region mutant can efficiently induce NKG 2D-mediated NK cell cytotoxicity, and the fusion antibody constructed by the MICA extracellular region mutant and scFv can effectively kill target cells by utilizing a high-affinity mutant MICA part and the like while efficiently targeting tumor cells by utilizing a tumor specific antibody part.