anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1. Use of essential fatty acids containing a mixture of eicosapentaenoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DMA) in the preparation of a medicament useful for preventing mortality in a patient who has suffered from a myocardial infarction where the content in EPA+DHA in such mixture is greater than 25% b.w; and the medicament is for oral administration. 2. Use according to claim 1, wherein the medicament is useful for preventing mortality due to sudden death in a patient who has suffered from a myocardial infarction. 3. Use according to claim 1 or 2, wherein the content in EPA+DHA in such mixture is 85% b.w. 4. Use according to claim 3, wherein the EPA/DHA ration in the EPA+DHA mixture is about 0.9/1.5. 5. Use of eicosapentaenoic acid ethyl ester (EPA) or docosahexaenoic acid ethyl ester (DHA) in the preparation of a medicament useful for preventing mortality in a patient who has suffered from a myocardial infarction, wherein the EPA or DHA content a greater than 25% b.w. and the medicament is for oral administration. 6. Use according to claim 5, wherein the medicament is useful for preventing mortality due to sudden death in a patient who has suffered from a myocardial infarction.
The unsaponifiable matter is recovered from a glyceride oil containing said matter by treating with alkali a solution comprising 3 to 50 per cent of said unsaponifiable matter, dissolved in a mixture of glycerides of said oil, and free fatty acids of said oil or soaps of said acids, whereby to convert the glycerides and any free fatty acids present into soaps, making up the mixture of soaps and unsaponifiable matter in a proportion of 100 parts by weight upon a water-free basis into solution in water in a proportion of 146 to 1460 parts by weight and a lower monohydric, saturated, alkyl alcohol containing 1 to 3 carbon atoms, in a proportion of 61 to 610 parts by weight, feeding the resultant soap solution countercurrently with a solvent of unsaponifiable matter insoluble in the soap solution in an extraction zone in a proportion of 1 to 10 parts by volume per part by volume of solution, drawing off the solution of unsaponifiable matter in said solvent at the end of the extraction zone opposite the end of introduction of the solvent and evaporating the solvent to recover the unsaponifiable matter contained therein.  As solvent for the unsaponifiable matter there may be used naphtha.  Methyl or isopropyl alcohol may be used as the alcohol.  A soap dispersion produced from 4 to 30 per cent of unsaponifiable matter of soybean oil and 5 to 40 per cent of free fatty acids of soybean oil by treatment with alkali and in which water is present in a proportion of 277.5 to 2775 parts and the alcohol is present in a proportion of 92.5 to 925 parts per each 200 parts of the mixture, may be utilized. Prior to making up the mixture of soaps and unsaponifiable matter the soaps may be acidified to liberate free fatty acids, the free fatty acids selectively distilled off from the unsaponifiable matter and the still residues subjected to saponification with alkali in order to convert the free fatty acids therein to soaps.  A solution resulting from the solvent extraction of soybean oil with furfural to produce a mixture of highly unsaturated glycerides, sterols (e.g. stigmasterol), inhibitors (mainly tocophenols) and free fatty acids, from which the glycerides are removed by extraction with naphtha and the furfural is removed by evaporation, may be utilized as starting material.  Specifications 625,674, 658,967 and 687,473, [all in Group III], are referred to.
The invention discloses a kind of pair of branch type shampoo pattern, it is characterised in that including：No. 1 agent and No. 2 agent；The operating procedure of No. 1 agent and No. 2 agent is as follows：First by person scalp is sent to No. 1 agent cleaning head once, and it is clean to wash by water；Then user is sent to scalp once with No. 2 agent hair washing, and rinses well.A kind of pair of branch type shampoo pattern disclosed by the invention, it is No. 1 agent by different formulations and the matched combined of No. 2 agent, same area can wash twice of custom when being washed hair using people, tradition is repeated twice hair washing with single shampoo it is changed into different purposes and has one's hair wash twice, it is not only easy to use, and hair washing function is more precisely reliable, is the upgrading and breakthrough of traditional hair washing product, tradition clean type can be achieved to accurate health convalescence type to upgrade, there are wide market prospects.
Saline solution 0.9% over 40 minutes. The intervention will be done twice weekly for 2 weeks, and then patients will receive intervention with ketamine as described above in the Active Comparator.
PURPOSE: A solid formulation containing L-cysteine or its salt is provided to reduce unpleasant smell and shorten manufacturing time. CONSTITUTION: A coating solid formulation is produced by coating film containing partial saponicated material of polyvinylalcohol in a solid formulation containing L-cysteine or its salt. The thickness of the coating film is 5 um or more. The degree of saponification is 70mol%~97mol%. The coating film further contains plasticizer, coating agent, dispersing agent, coloring agent or antifoaming agent. The solid formulation is used in the formulation of tablet, granule, and fine granule.
This study aimed to assess the effectiveness and safety of ab externo canaloplasty over a 3-year follow-up period in Polish Caucasian patients with glaucoma. This retrospective study of a cases series was conducted at the Department of Ophthalmology Medical University of Bialystok, Poland. Primary outcome measures were intraocular pressure and medication burden. Secondary outcome measures were best corrected visual acuity, retinal nerve fiber layer thickness, visual field test results, endothelial cell density, intraoperative and postoperative complications, and additional glaucoma surgery. The study group consisted of 160 eyes diagnosed with early to-moderate primary open-angle glaucoma and treated with ab externo canaloplasty from 2014 to 2020. The criteria for qualified and complete success were intraocular pressure < 18 mmHg or ≥ 20% reduction in intraocular pressure from baseline with or without antiglaucoma medications, respectively. After surgery, the mean intraocular pressure decreased from 19.23 ± 4.33 to 14.52 ± 3.79 mmHg, which constituted a 36.7 ± 7.8% reduction compared to the baseline value. The number of medications decreased by two at the end of the study period (from 2.69 ± 1.05 to 0.32 ± 0.75). Complete and qualified success were achieved in 58.7% and 68.7% of the patients, respectively, at the end of follow-up. An incomplete cannulation of Schlemm's canal was the most common intraoperative complication, occurring in 32 eyes (20%). The most frequent postoperative complications were hyphema, Descemet's membrane detachment, and a transient increase in intraocular pressure. Additional surgical procedure was required in seven cases (4.4%). In 16 patients (10%), medical treatment was re-administered. Overall, our findings suggest that ab externo canaloplasty is a good option for Polish Caucasian patients with primary open-angle glaucoma. It reduces intraocular pressure and has a low postoperative complication rate. Additional glaucoma surgery or re-administration of medications is required if the target intraocular pressure is unsatisfactory.
Inflammation after surgical incisions is related to the degree of tissue damage. Healing with low inflammation is desirable, especially in patients with compromised healing potential. This experimental study was conducted to assess the degree of inflammatory reaction and scar formation from incisions made by an ultra-polished scalpel (UPS). Two paravertebral incisions were made with a conventional scalpel (CS) and a UPS in 18 individual rats with diabetes. The fibrotic tissue (scar) area and expression levels of collagen, transforming growth factor, and matrix metalloproteinases were quantified on postoperative days 3, 7, and 30. The scar widths and areas were significantly lower in the UPS group than in the CS group. The scar widths were 64.3 ± 14.7 µm and 86.8 ± 12.1 µm in the UPS and CS groups, respectively ( P = 0.03). The scar areas were 11,398 ± 1595 µm 2 in the UPS group and 17,433 ± 3487 µm 2 in the CS group ( P = 0.014). The UPS group had less inflammation on day 3, less transforming growth factor synthesis on days 3 and 7, lower levels of matrix metalloproteinases, and less collagen synthesis on day 7 than did the CS group. The UPS achieved less local inflammation by reducing the local tissue damage in diabetic rat models, enabling better healing, and resulting in less scar formation. The UPS warrants further clinical study as it may bring beneficial outcomes for patients with impaired healing capability and patients who seek to reduce scarring.
Participatively developed intervention concept by means of cooperative planning (Rütten, 1997) to promote physical activity-related health competence (PAHCO): A separate cooperative planning process will take place in each of the four schools in this study arm from April to November 2023. Within the framework of these processes, suitable interventions tailored to the target group and the school will be developed for the implementation of the curriculum content "PAHCO" with the participation of actors from science and practice (e.g., teachers, nursing students of the schools). The developed interventions will be implemented from December 2023 under the responsibility of the actors in the schools.
PURPOSE: Uric acid stones (UAS) can be treated non-invasively by oral chemolysis. However, it is crucial to identify individuals who are most likely to benefit from this approach, specifically, patients with pure UAS. The aim of this study was to develop a nomogram that can differentiate between pure and mixed UAS.
METHODS: A retrospective analysis of demographic, clinical and stone composition data of patients with a predominant UAS composition (≥ 50%) treated between 2014 and 2022.
RESULTS: A total of 135 patients were included in the analysis, 37.8% had mixed UAS (50-90% UA) and 62.2% had pure UAS (≥ 95% UA). The mean stone density and the percentage of radiopaque stones in the pure UAS group were significantly lower than those in the mixed UAS group (450 Hounsfield Units [HU] vs. 600 HU, and 24% vs. 58%, respectively). A stepwise multivariate logistic regression revealed that lower stone density, bigger size, decreased stone opacity and older age are predictive variables for pure UAS. Accordingly, a nomogram was generated with a receiver operating characteristic (ROC) curve that showed an area under the curve (AUC) of 0.78. A patient with a total score of 156 has a probability of > 95% for pure UAS.
CONCLUSION: Imaging and demographic data can be used to identify patients with pure UAS. The nomogram may be useful for counseling patients regarding oral chemolysis. Future validation of the nomogram with a different data set is required to assess its efficacy.
BACKGROUND & AIMS: The study investigated the association between Helicobacter pylori treatment and the risk of gastric cancer after endoscopic resection of gastric dysplasia.
METHODS: Patients who received endoscopic resection for gastric dysplasia between 2010 and 2020 from Korean nationwide insurance data were included. We verified the occurrence of new-onset gastric cancer and metachronous gastric neoplasm, which encompasses both cancer and dysplasia, >1 year after the index endoscopic resection. Newly diagnosed gastric cancer ≥3 years and ≥5 years was regarded as late-onset gastric cancer. A multivariable Cox regression model with H pylori treatment status as a time-dependent covariate was used to determine the risk of gastric cancer and metachronous gastric neoplasms.
RESULTS: Gastric dysplasia in 69,722 patients was treated with endoscopy, and 49.5% were administered H pylori therapy. During the median 5.6 years of follow-up, gastric cancer developed in 2406 patients and metachronous gastric neoplasms developed in 3342 patients. Receiving H pylori therapy was closely related to lower gastric cancer risk (adjusted hazard ratio [aHR], 0.88; 95% confidence interval [CI], 0.80-0.96). H pylori treatment also significantly decreased metachronous gastric neoplasm development (aHR, 0.76; 95% CI, 0.70-0.82). Furthermore, H pylori therapy showed a prominent protective effect for late-onset gastric cancer development at ≥3 years (aHR, 0.84; 95% CI, 0.75-0.94) and ≥5 years (aHR, 0.80; 95% CI, 0.68-0.95).
CONCLUSIONS: In this nationwide cohort, H pylori therapy after endoscopic resection of gastric dysplasia was associated with a reduced risk of gastric cancer and metachronous gastric neoplasm occurrence.
In Arm B dosing subject will receive 10 mg of GSK598809 in Week 1, Placebo in Week 2, 25 mg of GSK598809 in Week 3, 75 mg of GSK598809 in Week 4. Subjects will have a wash-out of period of one week before receiving another dose.
A fast-acting formulation of vardenafil is provided to be rapidly solubilized in the mouth and increase medication compliance by improving convenience of dosage, thereby reducing the start time of erection. A fast-acting formulation of vardenafil contains vardenafil or pharmaceutically acceptable salts thereof and is formulated as porous tablet, freeze-dried tablet, soft chewing tablet, hard chewing tablet or sublingual tablet. The porous tablet is prepared by mixing vardenafil, pore-forming materials including menthol, campa, thymol, organic acid and lower fatty acid, and pharmaceutical additives, and tableting and heating the mixture. The soft chewing tablet is prepared by (i) dissolving vardenafil, oligosaccharide, sugar alcohol and starch syrup, (ii) adding an emulsifier into the solution and concentrating it under reduced pressure, (iii) cooling the concentrate, adding pharmaceutical additives into the concentrate and cooling it, and (iv) tableting the cooled mixture. The hard chewing tablet is prepared by mixing vardenafil, sugar or sugar alcohol and pharmaceutical additives, and tableting the mixture. The sublingual tablet is prepared by mixing vardenafil, sugar or sugar alcohol, acids and pharmaceutical additives, and tableting the mixture.
Patients and healthcare systems stand to gain much from the use of substances that can accelerate wound healing. In this research work, a polymeric patch was fabricated using polymers like poly (vinyl alcohol) (PVA) and Moringa oleifera gum (MO) incorporated with graphene oxide (GO) and naringin (Nar) (drug). This study determined the impact of using PVA/MO/GO/Nar polymeric patch on wound healing via in vitro and in vivo investigations. Graphene oxide was synthesized by modified Hummer's method. The synthesized sample was characterized using XRD, FT-IR, RAMAN Spectroscopy, FESEM and HRTEM. Antibacterial analysis of the GO on four different bacteria was studied through well diffusion, colony count, growth curve and biofilm assay. Biocompatibility was analysed by haemolysis assay. The morphology, antibacterial activity, haemolysis assay, swelling, degradation, porosity, water vapour transmission rate, drug release, blood pump model, in-vitro scratch assay and MTT assay were analysed for the fabricated polymeric patches under in-vitro condition. The PVA/MO/GO/Nar patch has shown enhanced wound healing in in-vivo wound healing experiments on albino Wistar rats.
Active Transcranial Direct Current Stimulation (atDCS) will be applied over the Primary Motor Cortex (M1) contralateral to pain if it is unilateral, or always on the left M1 if pain is bilateral. It will consist of 1 session of 20 minutes of conventional stimulation (anode over M1) at 2 mA. It will be applied in the OFF state (i.e., \>12h after the last medication intake). Lately, patients will take its usual dopaminergic medication.
OBJECTIVE: This study was designed to verify whether one or more clinical and neurophysiological parameters could predict a poor prognosis in idiopathic facial paralysis.
METHODS: Seventy-three outpatients with unilateral idiopathic facial nerve paralysis who visited our hospital within 7 days of onset. All patients received treatment according to a standard therapy protocol and ocular care. Patients' baseline characteristics were assessed before initiating treatment, including demographic characteristics, facial nerve function assessment and previous medical history. House-Brackmann (H-B) grading system was performed at baseline and six months after the onset. Electroneurography (ENoG) and blink reflex tests were conducted 7-10 days after the onset of paralysis. Sunnybrook Facial Grading System (SFGS) was conducted at baseline, days 7-10 post-onset when the electrophysiological tests were performed, and one month after the onset.
RESULTS: According to the H-B grade at 6 months following the onset, 58 patients (79.5 %) had a good prognosis, while 15 patients (20.5 %) had a poor prognosis. The CMAP amplitudes in three facial muscles (frontalis, orbicularis oculi, and orbicularis oris) were decreased, and ENoG values were increased in the poor prognosis group compared with the good prognosis group (all p < 0.01). The results of the blink reflex study showed that the group with a poor prognosis had a longer R1 latency compared to the group with a good prognosis. Additionally, the group with a poor prognosis exhibited a higher rate of R1 absence on the affected side (both p < 0.01). The findings of conditional logistic regression indicated that the absence of R1 on the affected side, frontalis ENoG, orbicularis oculi ENoG, and orbicularis oris ENoG were predictive factors of a poor prognosis for facial nerve palsy. The receiver operating characteristic (ROC) curves showed that the SFGS at 1 month after onset of 55 is considered a critical cutoff value for poor prognosis, with a sensitivity of 86.7 % and specificity of 91.4 %.
CONCLUSION: Electroneurography (ENoG) and blink reflex tests acquired within 7-10 days after the onset of paralysis are significant and highly valuable for predicting the prognosis of idiopathic facial nerve paralysis. Higher ENoG values of the muscles innervated by the facial nerve and the absence of R1 on the affected side of the blink reflex are predictive factors for a poor prognosis. The SFGS is a clinical tool that plays an important role in evaluating the prognosis of idiopathic facial paralysis, particularly one month after onset.
During receiving maintenance dose of 5 mg/kg caffeine citrate (i.e. 2,5 mg/kg caffeine) in the form of solution, orally or intravenously, Holter electrocardiogram and vital functions were monitored for 40 minutes.
BACKGROUND: More than 70% of respondents in a previous survey among paramedics reported use of coercion or physical force towards patients. Coercion outside hospital is not permitted, and neither routines nor equipment intended for physical restraint is available in the Norwegian ambulance services. Paramedics carry out assignments involving use of force and coercion on unclear legal grounds, with no training in techniques or proper equipment. Attitudes and experiences of healthcare workers regarding incidents involving coercion in mental health care services are frequently reported in the research literature, yet little is known about paramedics' experiences, and which factors contribute to their moral stress.
METHODS: In the period June-August 2021, almost 400 employees in the ambulance services in a county in the eastern part of Norway were invited to answer a digital questionnaire. One question had an open text field with the question "Can you say something about how you experience transporting patients where force has to be used to secure the patient during transport?". The answers were analyzed using Graneheim and Lundman's content analysis.
RESULTS: We received eighty-five completed responses (response rate 21%). Force was used by 62 paramedics. Twenty-three left the text field open. The answers showed many unique responses. Content analysis resulted in two overarching themes; 1) lack of routines, equipment, and training regarding use of coercion and force in the ambulance service, and 2) paramedics were confronted with ethical dilemmas, alone and without support from legislation or management.
CONCLUSIONS: The paramedics experienced discomfort related to the exercise of force and coercion during ambulance assignments due to the experience of unclear legislation, lack of training, routines, and equipment in addition to frequent ethical dilemmas and the concern about lack of support from the employer. A clearer legal basis, adapted equipment in the ambulance and regular training, will contribute to greater security in the performance of the work, which will provide safer and more caring treatment for the patients and less moral stress for the staff. With established routines, the employer will be implicitly obliged, and paramedics will be safer in the performance of their work. Ethical reflection must be offered and put into a system.
All interns except the ones who previously worked in allergy department in a medical school were invited to the study. Two identical epinephrine autoinjector trainers (Epipen trainer®) were used, one of which was modified by changing gray safety cap to red and placing a yellow arrow pointing to the black injection tip. Written and visual instruction sheet for each trainer was provided. Participants were asked to demonstrate the use of Epipen trainer either with the original or the modified one. They were scored and timed for demonstration. Primary study parameter was the rate of participants correctly demonstrating the use of epinephrine autoinjector. Secondary study parameters were the mean total score, mean time required to administer autoinjector and unintentional self injection of autoinjector into thumb.
This is a prospective, randomized study with two cohorts: one experimental and one control. Anteroposterior (AP) and lateral (LAT) radiographs are routinely obtained as standard of care during spine surgery to confirm proper implant placement. These images will be used in this study. In one-half of the study subjects, after all sponges are removed, a surgical sponge will be intentionally placed in the surgical field prior to imaging. Postoperatively, each subject's images will be assessed for the presence or absence of a retained surgical sponge. Images will be independently read by two investigators. When there is discordance, the images will be adjudicated by a third. Interobserver agreement will be quantified using the Kappa statistic. Those reading images will not have participated in the surgery.