anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The study will be performed outside the pollen season. On a baseline visit, 2 to 7 days prior to control challenge, allergy skin prick tests and methacholine inhalation test will be done. Prior to first allergen challenge, skin titration will be done using tenfold dilutions of the allergen chosen for nasal challenges. Subsequent to baseline visit, a control challenge will be done, followed, a week later, by repeated NACs. NACs will be done over 4 consecutive days, in the morning. Nasal peak inspiratory flows (NPIF), oral peak expiratory flows (PEF), and symptoms will be recorded at baseline and at regular intervals over 7 hours post-challenge on each challenge day. Induced sputum and nasal lavage specimen will be obtained 7 hours following the control challenge and the first and last NAC.
PURPOSE:To obtain a cosmetic having excellently beautifying effects on skin, sufficient shelf stability and high safety. CONSTITUTION:First, kefia granules are inoculated into 10% reduced defatted milk, subjected to subculture every day at 20 deg.C and activated. The activated kefia granules are cultured by using a medium for separating cells of lactic acid bacteria of the genus Lactobacillus and the cells of lactic acid bacteria of the genus Lactobacillus are separated. Then, the cells are inoculated into a medium, subjected to stationary culture or mild spinner culture at 20-35 deg.C and the culture solution is centrifuged to collect cells. 1 pt.wt. of the cells is extracted with 2-10 pts.wt. solvent at 0-40 deg.C for 1-24 hours, the obtained filtrate is concentrated to give a cell extract (extracted solution). A cosmetic is blended with 0.01-0.5% of the extract as an active ingredient.
Participants included in this group are characterized by advanced age (≥35 years) and meet at least one of the following criteria: 1. Number of oocytes retrieved in the current IVF cycle ≤9; 2. Diminished ovarian reserve: level of anti-Mullerian hormone\<1.2 ng/ml or number of antral follicle count \<5. All participants in this group receive the standard operation protocol for In vitro fertilization and embryo transfer.
The invention discloses a brain-tonifying and nerve-soothing beverage for alleviating brain traumas. The beverage is prepared from the following main raw materials in parts by weight: 9-15 parts of angelica dahurica, 6-12 parts of centella, 10-15 parts of kirilow rhodiola rhizome and roots, 5-10 parts of ossa draconis, 6-12 parts of apocynum venetum, 50-70 parts of semen juglandis, 5-15 parts of lucid ganoderma, 4.5-9 parts of longans, 5-15 parts of lumbricus, 2-5 parts of radix achyranthis bidentatae, 5-15 parts of salvia miltiorrhiza, 2-7 parts of cassia twig, 3-7 parts of deer-horn glue and 5-10 parts of olibanum. The brain-tonifying and nerve-soothing beverage disclosed by the invention is based on the principle of dialectical treatment of traditional Chinese medicine. The selected medicinal materials are used for relieving pain of symptom, tonifying brain and soothing the nerve and have the main effects of promoting circulation and removing stasis, clearing damp and eliminating swelling and tranquilizing and allaying excitement. In addition, the beverage further has the effects of reinforcing qi and nourishing blood, eliminating phlegm and calming wind, inducing resuscitation and restoring consciousness and the like and belongs to a medicine which considers inside and outside and is safe and effective. The beverage has an extremely good curative effect for brain traumas.
The behavioral weight loss (BWL) + weight bias internalization and stigma (BIAS) group will include standard BWL treatment (described in more detail in Intervention section) combined with a weight stigma-reduction intervention. During the initial 12 weeks, the weekly 60-minute BWL sessions will be followed by 30 minutes devoted to stigma-related content. In the every-other-week and monthly weight loss maintenance sessions from weeks 13-26, strategies for coping with weight stigma and challenging internalized beliefs will be reviewed, and participants will be encouraged to use these strategies specifically in the context of weight management.
The original English version of Kujala Questionnaire will be translated and culturally adapted as per previous recommendation. In patients with anterior knee pain or patella femoral knee pain, Kujala Questionnaire-Urdu will be distributed among hundred participants choose a convenience sampling technique based on pre-defined inclusion and exclusion criteria. To test reliability of inter/intra observer of ultimate final Urdu Version of Kujala, 36-Item Short Form Health Survey questionnaire, Lysholm Knee Scoring Scale and 2000 International Knee Documentation Committee Subjective Knee Evaluation Form will be filled from patients on the equivalent day, by 2 different bystanders, and for inter observer valuation, with an interval of 30 minutes between the first and second application. Third assessment will be carried out after 7 days of the Observer -1 (re-testing), for intra-observer assessment. Data will be entered and analyzed Cronbach alpha value. Test-retest reliability will be assessed using an intraclass correlation coefficient. Urdu Version of Kujala was evaluated for content validity, construct validity, criterion validity and responsiveness.
Chronic heart failure (CHF) can induce chronic kidney disease (CKD), called type 2 cardio-renal syndrome (CRS2). The mechanism is not completely clear, and there is a lack of early warning biomarkers of CKD in the context of CHF. Two CKD, one CHF-PBMC and four CHF-cardiac tissue expression profile datasets were obtained from GEO database. Differential expression analysis and WGCNA were used to detect CKD key genes and CHF-related secreted proteins. Protein-protein interaction (PPI), functional enrichment, and cMAP analysis reveal potential mechanisms and drugs of CHF-related CKD. Five machine learning algorithms were used to screen candidate biomarkers, construct a diagnostic nomogram for CKD and validate it in two external cohorts. Clinical serum samples were collected in our hospital to evaluate the correlation and diagnostic value of biomarkers and CKD. 225 CKD key genes and 316 CHF-related secreted proteins were identified. Four key subgroups, including 204 genes, were identified as CRS2-related pathogenic genes by PPI analysis. Enrichment analysis revealed that the identified subgroups exhibited significant enrichment in cytokine action, immune responses, and inflammatory processes. The cMAP analysis highlighted metiradone as a drug with greater potential for therapeutic intervention for CRS2. Utilizing five machine learning algorithms, three hub genes (CD48, COL3A1, LOXL1) were pinpointed as potential biomarkers for CKD, and a nomogram model was constructed. Receiver operating characteristic analysis demonstrated that the nomogram's area under the curve (AUC) exceeded 0.80 in both the CKD combined dataset and two external cohorts. In addition, the three biomarkers were significantly correlated with the glomerular filtration rate, and the AUC of the model predicting disease progression was 0.944. Furthermore, analysis of immune cell infiltration indicated a correlation between the three biomarkers and the infiltration fraction of macrophages, neutrophils, and other immune cells in CKD. Our clinical cohort validated the expression patterns of three biomarkers in serum, and the diagnostic model achieved an AUC of 0.876. CHF has the potential to facilitate the progression of CKD via the release of cardiac and PBMC secreted proteins. Furthermore, CD48, COL3A1, and LOXL1 have been identified as potential biomarkers for the detection of CKD.
The invention provides a quick-result bone setting plaster, which is refined from various Chinese medicinal herbs: freshwater turtle shell, Chinese polyphaga, radix notoginseng, frankincense, myrrh, rhizoma drynariae, dragons blood, teasel root, etc. The plaster of the invention is applied on an external surface muscle at an osteocomma of a fracture patient, for rapidly healing a fracture end. For example fracture of femoral shaft, operation is needed in a traditional treating method, steel plate is used for fixing, then cut is stitched, and large dose of antibiotic is used for diminish inflammation, and clinic healing needs 100 days. Based on treatment of the invention, only contraposition of a fracture part is needed under an X-ray microscope, the quick-result bone setting plaster is applied on the external surface muscles of the fracture part, and then five pieces of wood plates are tied around the fracture part, and tightly tied with cloth belts. By using the plaster in the invention, without operation and internal fixation by steel plates, and without diminish inflammation by antibiotics, clinic healing needs only 50 days, 50% of time advance. The plaster can saves 30, 000 Yuan of medical fee for one patient and the state, without operation pain and side effect.
The invention discloses a traditional Chinese medicine pill of wind-stroke collateral-activating wind-dispelling pill, which is prepared from the following components in parts by weight: the invention relates to a traditional Chinese medicine composition for treating apoplexy, which comprises 10 traditional Chinese medicines of suberect spatholobus stem, tangerine and medlar, Chinese angelica, salvia miltiorrhiza, long-noded pit viper, centipede, earthworm, safflower, honeysuckle stem, wood louse and the like. 1. Has no influence or little influence on normal physiological functions and no toxic or side effect. 2. The effect is nonspecific and broad-spectrum. 3. Has effects in regulating physiological function, activating collaterals, dredging channels, removing blood stasis, promoting blood circulation, expelling pathogenic wind, calming endogenous wind, eliminating turbid pathogen, improving apoplexy sequelae, hemiplegia, numbness of limbs, facial distortion, language disorder, promoting blood circulation, and regulating visceral function. 4. Can improve the clinical symptoms and physical signs of the patients with the apoplexy and has the function of relieving and recovering the sequelae of the apoplexy.
At University of California San Francisco, there are approximately 100 pediatric renal biopsies per year. All of these patients receive sedation, which is prescribed and supervised by the pediatric pain and palliative care team, with either ketamine or fentanyl and versed. Child life is involved; however, many children still experience anxiety and/or pain with the procedure. Use of a modality such as aculaser which may decrease these symptoms could enhance their experience.

The term "laser" stands for light amplification by stimulated emission of radiation. In laser acupuncture, a low power, cold light produced by a low-level laser diode is used to stimulate an acupuncture point. As it is non-invasive, laser acupuncture is thought to be safer than needle acupuncture, especially in the setting of patients with blood-borne infectious diseases. In a systematic review analyzing the evidence to support the effectiveness of laser acupuncture, randomized control trials in which adults with soft tissue injury, acute or chronic pain condition, or any systemic illness were included. This review reports moderate level of evidence for treatment of myofascial pain and post-operative nausea/vomiting and limited evidence of the clinical effectiveness of treating chronic tension headaches. Of note, no complications of the use of aculaser were reported in this review (1).

1. Baxter GD, Bleakley C, McDonough S. Clinical effectiveness of laser acupuncture: a systematic review. J Acupunct Meridian Stud. 2008 Dec;1(2):65-82.
A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine.  Synergistically effective amounts are preferred. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds.  As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, doxorubicin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents.  Alternatively, the first treatment may be a treatment with one or more conventional anti-hormonal agents. As examples, the anti-hormonal agents may be a LHRH (luteinizing hormone releasing hormone) agonist or an anti-androgen such as flutamide, biclutamide, nilutamide, and luprolide. These conventional cancer treatments compounds and the squalamine may be administered by any suitable route. The first treatment procedure may take place prior to the second treatment procedure, after the second treatment procedure, or the two treatment procedures may take place simultaneously. As an alternative, the first treatment procedure may be a conventional radiation treatment regimen.  As a further alternative the first treatment procedure may be a combination of treatment with one or more conventional cytotoxic chemical compounds and a conventional radiation treatment regimen.
Following peripheral nerve injury, postganglionic sympathetic axons sprout into the affected sensory ganglia and form perineuronal sympathetic plexuses with somata of sensory neurons. This sympathosensory coupling contributes to the onset and persistence of injury-induced chronic pain. We have documented the presence of similar sympathetic plexuses in the trigeminal ganglia of adult mice that ectopically overexpress nerve growth factor (NGF), in the absence of nerve injury. In this study, we sought to further define the phenotype(s) of these trigeminal sensory neurons having sympathetic plexuses in our transgenic mice. Using quantitative immunofluorescence staining analyses, we show that the invading sympathetic axons specifically target sensory somata immunopositive for several biomarkers: NGF high-affinity receptor tyrosine kinase A (trkA), calcitonin gene-related peptide (CGRP), neurofilament heavy chain (NFH), and P2X purinoceptor 3 (P2X3). Based on these phenotypic characteristics, the majority of the sensory somata surrounded by sympathetic plexuses are likely to be NGF-responsive nociceptors (i.e., trkA expressing) that are peptidergic (i.e., CGRP expressing), myelinated (i.e., NFH expressing), and ATP sensitive (i.e., P2X3 expressing). Our data also show that very few sympathetic plexuses surround sensory somata expressing other nociceptive (pain) biomarkers, including substance P and acid-sensing ion channel 3. No sympathetic plexuses are associated with sensory somata that display isolectin B4 binding. Though the cellular mechanisms that trigger the formation of sympathetic plexus (with and without nerve injury) remain unknown, our new observations yield an unexpected specificity with which invading sympathetic axons appear to target a precise subtype of nociceptors. This selectivity likely contributes to pain development and maintenance associated with sympathosensory coupling.
Background: The posterior cruciate ligament (PCL) is an essential structure in knee stabilization. Knee cartilage degeneration after a PCL injury has been reported in several studies. Understanding the changes in movement patterns of patients with PCL ruptures could help clinicians make specific treatment protocols to restore patients' sporting ability and prevent joint degeneration. However, the kinematics and kinetics of the lower limb in patients with PCL injuries are still not clear.

Methods: Three-dimensional gait analysis system, force plate, electromyography will be used for 55 healthy male participants (control group) and 55 male patients with isolated PCL-deficiency (PCL-d group) during walking, jogging, cutting, jumping. Repeated measurement two-factor analysis of variance will be performed to determine differences between involved and uninvolved legs in the PCL-d group and control group at different rehabilitation times (prior reconstruction surgery, 6 months, and 1-year post PCL reconstruction surgery). Three-dimensional gait analysis and computer-aided analysis technology of plantar pressure information were used to study the changes of PCL after fracture and reconstruction. Based on the plantar pressure information, the movement parameters, and individual attribute parameters, establish a knee joint biomechanical evaluation model to quantify and evaluate the plantar pressure information under dynamic load-bearing state after PCL fracture. Provide a precise basis for the biomechanical state of the knee, and establish a clinically practical automatic analysis of plantar pressure information and an expert diagnostic system.
Methods are provided for loading polymeric regions of medical devices with therapeutic agents. In these methods, a polymeric region of a medical device is first pretreated with a solvent system. Subsequently, therapeutic-agent-containing particles are impacted into the pretreated polymeric region at a velocity that is effective to at least partially embed the particles within the pretreated polymeric region. The pretreatment step parameters (e.g., the particular solvent system employed, amount of time that the solvent system contacts the polymeric region, etc.) are typically selected such that the surface tack of the polymeric region is increased. Consequently, the depth, the amount, or both the depth and the amount of the particles that become at least partially embedded in the polymeric region is/are typically increased, relative to what would be achieved in the absence of the pretreatment step. Also provided are medical devices made by such methods.
A cosmetic composition used for lip makeup is described. The cosmetic composition is applied to the lips to form a layer comprising a resistant film on the surface of the lips. This formed film promotes full adherence, with no loss, smudging or transfer in situations such as eating, kissing, toothbrushing, abrasion, inter alia. The objective of the present invention is to provide a cosmetic composition for lip makeup comprising at least one volatile silicone oil; dimethicone/vinyl dimethicone crosspolymer, nylon-611/dimethicone copolymer; at least one pigmentation agent; at least one trimethylsiloxysilicate resin; at least two silsesquioxane resins with the empirical molecular formula [RSiO3/2]n, in which n is greater than 1, R independently comprises alkyl groups of 10 to 45 carbon atoms; and in this silsesquioxane resin the groups R include at least 40% (in moles) of propyl groups; and a volatile-solvent-based binary component associated with a crosspolymer in the form of gum silicone resin. The cosmetic composition has been tested for resistance against abrasion with and without the presence of vegetable oil, flexibility, hydrophobicity, stickiness and resistance to saliva. The cosmetic composition showed no transfer in the tests carried out, resisting abrasion and saliva situations (both simulating kissing), vegetable oil (simulating meals) and toothpaste, and also showed flexibility (for comfortable application), hydrophobicity (for rapid drying after application) and durability.
Currently, there is a lack of data on the effects of altering feed levels on sow performance and piglet characteristics during the transition period in tropical environments. The present study determined the effect of sow feed levels during the transition period on colostrum yield, colostrum immunoglobulin (Ig) G, colostrum intake of piglets, farrowing duration, proportion of stillborn piglets per litter (SB) and the incidence of farrowing assistance in highly prolific sows. A total of 114 Landrace × Yorkshire crossbred sows and their offspring (n = 2 072) were included in the experiment. Sows were assigned to different feed supply levels from entry to farrowing at 110 days of gestation until farrowing based on their parity number. Three feed-level groups were the control group who received 3.0 kg/day of lactation feed (n = 40), treatment 1 group who received 3.6 kg/day of gestation feed (n = 39) and treatment 2 group who received 4.0 kg/day of lactation feed (n = 35). Colostrum samples (5 ml) were obtained from the sows within 3 h after the onset of farrowing for IgG assay. Piglets were weighed immediately after birth and then again 17-24 h later to estimate their colostrum intake. Colostrum yield was determined by aggregating the colostrum intake of piglets within the litter. The total number of piglets born, SB and farrowing duration were 18.2 ± 3.8, 7.5% and 259.1 ± 138.1 min, respectively. Among these sows, 28.9% experienced a farrowing duration exceeding 300 min and 50.9% required assistance during farrowing. Interestingly, piglets in the treatment 2 group demonstrated a greater colostrum intake (403.1 ± 14.9 g) compared to the control group (360.6 ± 15.1 g, P = 0.046) and the treatment 1 group (361.0 ± 12.9 g, P = 0.033). On average, colostrum yield of sows in the treatment 2 group tended to be higher than in the control group (+0.5 kg, P = 0.081), but did not differ from the treatment 1 group (+0.3 kg, P = 0.191). No significant differences in farrowing duration, SB, farrowing assistance, or colostrum IgG concentration were found across various feed-level groups (P > 0.05). In conclusion, the study showed that raising lactation feed by 1.0 kg/day prefarrowing increased piglet colostrum intake and tended to boost sow colostrum production, without significantly affecting farrowing duration, stillbirth rates, or need for assistance.
Patients will be stratified according to the use of prophylactic antibiotics. Both groups may receive open-label gram-negative coverage with either ceftazidime, aztreonam, and/or aminoglycosides (gentamicin, tobramycin, amikacin). Subjects will receive study medication intravenously every 12 hours for 7 to 28 days.
The present invention relates to the use of certain microspheres, nanospheres, and other structures to provide a method of marking or masking identifying marks in individual biological hosts. Biological hosts for the present invention may include humans, other animals, or plants. Such methods may be used to sense, signal, track, mark, or identify individual biological hosts. Microspheres, nanospheres, and other structures of the present invention may be implanted, injected, ingested, or attached to individual biological hosts. Microspheres, nanospheres, and other structures of the present invention comprise poly[bis(trifluoroethoxy)phosphazene] and/or a derivative thereof which may be present throughout the particles or within an outer coating of the particles. The microspheres, nanospheres, and other structures may also comprise a core having a hydrogel which may further comprise one or more dyes or other chromophoric agents covalently bound permanently to the hydrogel core material. The microspheres, nanospheres, and other structures and/or the hydrogel core may further comprise radio frequency or other electronic chips or nanochips, capable of transmitting and/or receiving electronic signals from external transmitters and/or receivers.
A method for treatment of depression and depressive mood disorders. The patient is administered an amount of a compound that increases the catalytic activity of MAO-A, so as to increase synaptic metabolism of serotonin to 5-HIAL. The effective compound is preferably reserpine, administered in a dosage of less than about 0.03 mg per day. The reserpine may be administered transdermally at a dosage in the range from about 0.002 mg per day to about 0.02 mg per day. A caffeine compound may be administered simultaneously so as to compensate for an antihypertensive effect of the reserpine. The caffeine compound may be combined with the reserpine in a transdermal cream.