anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The current theory of cryptoglandular suggest that perianal fistula occurs when the anal crypt glands become occluded and infected, over 90% of perianal fistulas are cryptoglandular in origin and arise from perianal abscesses. Also inflammatory process might play an important role in the formation of cryptoglandular perianal fistula. This condition is mainly managed with surgery, currently remain majorly on two conventional surgical interventions--fistulotomy and fistulectomy.

MPFF is a drug to treat venous vessel disease such as varicose and hemorrhoid, which was found with effects of lowering lymphatic permeability, improving venous return and vessel endothelial inflammation. More research has also shown the effects of MPFF on post hemorrhoidectomy symptom control, such as bleeding, pain, and infection. Since other anorectal surgery has similar complications. Therefor we conducted this randomized control trial to evaluate the benefits of MPFF after anal fistula surgeries.
OBJECTIVE: To evaluate the efficacy and safety of the polytetrafluoroethylene (PTFE) mesh by comparing conventionally used polypropylene (PP) mesh in tension-free vaginal mesh (TVM) surgery for pelvic organ prolapse (POP).
METHODS: We conducted an observational cohort study of patients who underwent TVM using a PTFE or PP mesh. PTFE was used from June 2019 to May 2021, and PP mesh from January 2018 to May 2019. Outcomes included POP recurrence, perioperative complications, and patient satisfaction. Restricted mean survival time was used to analyze POP recurrence, comparing the time to recurrence between the two groups at 1year after TVM.
RESULTS: Of 171 patients, 104 underwent PP mesh placement (PP group) and 67 underwent PTFE mesh placement (PTFE group). POP recurrence was observed in 10 and nine patients in the PP and PTFE groups, respectively. The mean time until the recurrence in the PTFE group was significantly shorter than that in the PP group (restricted mean survival time difference: -20.3days; 95% CI, -40.1 to -0.5; P = .044). Subgroup analysis revealed the meantime until recurrence was significantly shorter in the PTFE group for postoperative periods 3months or less, ages >70years, and POP stage ≥3. There were no intervention cases in either group and no significant differences in the perioperative complications. Patient satisfaction was greater in the PTFE group after 3months postoperatively.
CONCLUSION: TVM surgery with a PTFE mesh is more prone to recurrence than that with a PP mesh, but with higher patient satisfaction. Within 3months of surgery, elderly patients and those with advanced-stage POP require care to prevent recurrence.
The COVID-19 pandemic poses an unprecedented global health crisis that has affected healthcare systems around the world. Those working in the health sector are at the forefront of this pandemic and naturally have been deeply impacted by it. Health care workers are at risk of serious physical exhaustion owing to long shifts, a major increase in workload and working under high-stress conditions. Shortage of Personal Protective Equipment (PPE) in many hospitals carries a serious health risk for not only healthcare workers but their families and patients as well. In addition to the physical toll that the pandemic has taken on doctors and other healthcare professionals, it has also affected their mental health deeply with an increase in anxiety and depression. Witnessing firsthand what this virus can do, yet stepping in daily into a high-risk area and exposing oneself to possible risk of infection, takes its toll on one's psychological well-being. However, the pandemic has allowed health care professionals to show higher levels of perseverance and professionalism in the face of the pandemic.

In view of how the COVID-19 pandemic has affected healthcare workers and the perception of the medical field around the world, the aim of this cross-sectional study is to determine what impact this may have had on the choices of high school students to pursue medicine as a career.
Type 2 diabetics and insulin resistant individuals have an excess of fat in the liver which is not attributable to alcohol or other known causes of liver disease, a condition defined as nonalcoholic fatty liver disease (NAFLD). The fatty liver is insulin resistant. Individuals with a fatty liver are more likely to have excess intra-abdominal fat as well as a reduction in circulating plasma adiponectin levels. We have previously shown that type 2 diabetes and its associated Non Alcoholic Fatty Liver Disease (NAFLD) is characterized by increased hepatic fat content, decreased circulating adiponectin levels, and hepatic and peripheral (muscle) insulin resistance. Weight loss in humans with Non Alcoholic Fatty Liver Disease is associated with a decrease in hepatic fat content. Exenatide, an incretin based anti-diabetes therapy, enhances glucose-dependent insulin secretion and glucose-dependent suppression of inappropriately high glucagon secretion, improves glycemic control in patients with type 2 diabetes and is associated with weight loss. In rodent studies, exenatide reduces hepatic and myocardial fat and reduces vascular inflammation independent of changes in weight. Exenatide has also been shown to increase plasma adiponectin levels in humans and rodents. Furthermore type 2 diabetics are characterized by an increase in both hepatic and myocardial fat and left ventricular dysfunction, particularly diastolic dysfunction. However, the effect of exenatide therapy on liver and myocardial fat content, as well as left ventricular function in patients with type 2 diabetes has not been previously studied.
### Risk Summary

Contraceptive hormones and/or metabolites are present in human milk. COCs can reduce milk production in breast-feeding females. This reduction can occur at any time but is less likely to occur once breast-feeding is well-established. When possible, advise the nursing female to use other methods of contraception until she discontinues breast-feeding. (see DOSAGE AND ADMINISTRATION). The developmental and health benefits of breast-feeding should be considered along with the mother's clinical need for LEVORA 0.15/30-28 and any potential adverse effects on the breast-fed child from LEVORA 0.15/30-28 or from the underlying maternal condition.
Placental malaria (PM) leads to poor outcomes for pregnant women and their babies, and is caused by Plasmodium falciparum sequestration in the intervillous spaces of the placenta and ensuing inflammation. Severe maternal anemia, low birth weight (LBW) delivery and fetal loss are common sequelae. Malaria-related LBW alone is estimated to cause 62,000-363,000 infant deaths in Africa each year. To reduce poor pregnancy outcomes associated with malaria infection, WHO recommends monthly anti-malarial treatment with sulfadoxine pyrimethamine (SP) during the second and third trimester and the use of insecticide-treated bed nets. However, in East and Southern Africa, SP has lost its efficacy due to the spread of drug-resistant parasites. Therefore, an effective vaccine for PM is needed. Although the ideal vaccine will be given to adolescent girls prior to becoming pregnant, at this early stage of pregnancy malaria vaccine development, it is unknown if a boosting dose may be needed during pregnancy.

Before testing new interventions to improve pregnancy outcomes, it is important to obtain baseline information on pregnancy outcomes in the target population. In our recent longitudinal study of 1,885 pregnant women in Mali, in which women were closely followed during pregnancy (including malaria prevention and treatment), 2.9%, 2.4% and 6% of pregnancies ended in miscarriage, stillbirth, and preterm delivery, respectively.

The primary goal of the study is to assess pregnancy outcomes in women in the community with access to the WHO recommended standard of care. In the first part of the study, all women presenting for an antenatal visit at Ouelessebougou health centers will be recruited into the study. In the second part of the study, non-pregnant women will be enrolled and followed to capture data on pregnancy outcomes including early pregnancy losses. Pregnancy outcome information will be collected after the birth of the child or after pregnancy termination (i.e. miscarriage/stillbirth). Primary and secondary endpoints will be analyzed using appropriate statistical methods, including possible confounders, to determine the prevalence and factors associated with poor pregnancy outcomes.
PURPOSE:To obtain ultrafine spherical chitosan useful as a filler for chromatography, etc., by coagulating and regenerating an acidic aqueous solution of chitosan, crushing and dispersing the coagulated product after washing and drying the dispersion by blasting together with compressed air into hot atmosphere. CONSTITUTION:A low-molecular chitosan having an average molecular weight of preferably 10,000-230,000 is dissolved in an acidic aqueous solution of e.g. acetic acid, etc., and the obtained solution is added to a basic solution (e.g. ammonia, ethylenediamine, etc.) to effect the coagulation and regeneration of the chitosan. The coagulated product is washed, crushed and dispersed in water and blasted together with compressed air in a hot atmosphere (preferably heated at 100-180 deg.C) to effect the drying of the particle and obtain the objective ultrafine spherical chitosan.
FIELD: veterinary science. SUBSTANCE: new complex probiotic preparation has bacterium cells as an active component that are representatives of animal and poultry intestine microflora, and component showing interferon-like activity. The latter is recombinant alpha-interferon or recombinant gamma-interferon, or their mixture. Preparation can be used as different medicinal forms (solids, powders) and used as additions to dry and liquid fodder, at total aerosol agriculture animals treatment, at individual treatment and disease prophylaxis. EFFECT: enhanced effectiveness of preparation. 2 tbl
Annually, there are more than 200 million surgeries worldwide (Weiser et al., 2016; Weiser et al., 2008). The POISE study revealed 5% of patients undergoing a non-cardiac surgery suffer perioperative myocardial infarcts going along with a perioperative mortality rate of about 11,6% (Devereaux et al., 2011). Possibilities to preoperatively identify patients at risk are limited (Devereaux und Sessler, 2015; Gillmann et al., 2014) and prophylactic interventions are not yet established or controversial (Devereaux und Sessler, 2015).

Selected leukocyte subpopulations have been demonstrated to be associated with higher risk for cardiovascular events (Berg et al., 2012; Cheng et al., 2008; Engelbertsen et al., 2012; Kotfis et al., 2015; Rogacev et al., 2011; Rogacev et al., 2012).The aim of this study is to analyze whether surgical stress (non-cardiac surgery) induces a quantitative change in one or several of these leukocyte subpopulations and whether quantitative changes are associated with perioperative cardiovascular events. Therefore, high-risk cardio-vascular patients scheduled for non-cardiac surgery will be recruited. Blood will be drawn at predefined time points before surgery and up to three days postoperatively. Leukocytes will be analyzed by flow cytometry. During 30 day follow up adverse cardiovascular events will be recorded. ECGs will be recorded preoperatively and on post-OP day 3. High-sensitive cardiac Troponin T will be measured prior to the operation and on post-OP day one to three. The patient chart will be screened for cardio vascular events up to day 30. A telephone interview will be performed to detect cardiovascular events after discharge until post-OP day 30.
FIELD: medicine. SUBSTANCE: composition is produced as globules with controlled release of drugs having nucleus with regular seed or seed with homogeneously distributed glycocorticosteroid described in the invention application. Regular seed nucleus has budesonide or its 22R-isomer layer. The drugs show significant advantages when compared to other glycocorticosteroids of systemic activity and other drugs earlier applied for treating Kron disease. EFFECT: no systemic adverse side effects; high speed in passing metabolism pathway; high reliability when applied as supporting therapy in acute phase of disease. 25 cl, 8 tbl
Detrusor overactivity (DO), defined as a rise in detrusor pressure during bladder filling on urodynamic evaluation (UDE), is presumed to be involved in the pathophysiology of overactive bladder syndrome (OAB) and urge urinary incontinence (UUI). However, the mechanism of DO is not fully understood and the detection rate of DO on UDE is low. Currently there is limited data in the literature investigating audiovisual stimulation of DO. To improve the understanding of the neural regulation of micturition, the investigators propose adding an audiovisual stimulant to standard UDE. Methods: 218 women with OAB and/or UUI undergoing UDE will be recruited. Subjects will be randomized to standard care versus standard care with the addition of an audiovisual stimulant, involving the patient listening to running water and watching a video of several well-known triggers. The primary outcome will be proportion of patients in whom detrusor contractions are seen. Secondary outcomes will include number, amplitude and length of contractions and presence of incontinence associated with a contraction. The objective of this study is to estimate the effect of adding audiovisual cues during UDE on the proportion of patients in whom DO is detected compared to standard clinical care. The hypothesis is that the proportion of patients in whom detrusor contractions are seen will be higher in female patients with OAB symptoms and/or UUI using an audiovisual stimulant. Data obtained will be analyzed by chi square, t-tests, and multivariable logistic regression analysis as appropriate.
ABSTRACT        An infusion management and pumping system is disclosed.          Infusion prescriptions are generated and monitored by a pharmacy management system.   Labels  for each infusion to be given to a patient are generated and printed in a bar code format.   Each label  contains  data  regarding  a  prescribed  infusion  program, including the drug or drugs to be infused, the infusion regimen, the expiration date, and the patient to whom the infusion is to be    administered.     The   management    system   checks    for incompatibilities  between drugs  that  are being  prescribed for simultaneous infusion.   Each label generated by the management system is  attached  to  the container which holds  the  infusion solution.  The data on the label is transferred to an infusion pumping  system by a  bar  code  reader  at  the infusion  pumping system.  The pumping system checks that all necessary data has been entered.  During operation, the pumping system checks for a variety of alarm conditions and stores any alarms in a ranking according to urgency.  The infusion pumping system is responsive to  remote  or  biofeedback  instructions  to  alter  the  planned infusion program.  Central computer records processing receives infusion data and provides infusion, inventory, and use analysis.
An intelligent system for efficiently preventing epidemic propagation by using a mobile phone and a network; the method comprises the following steps: the system comprises a smart phone, a service platform, a display device, a management terminal and an inspection terminal. Installing an epidemic prevention APP in a mobile phone, and regularly prompting a user to measure human body indexes; and acquiring the track of the user through mobile phone acquisition. And (5) communicating with the user by using AI software to form an epidemic prevention index. And identifying and confirming suspected persons according to the epidemic prevention indexes. And limiting the trip of suspected personnel by network technology. And the service platform applies AI comparison software and analyzes the contact history. And granting pass codes to health up-to-standard personnel. The pass code consists of a graphic code, a flashing icon and a head photo. The inspector checks the pass code by eyesight to prove that the health of the user reaches the standard and is granted permission. The body temperature measurement at the intersection can be cancelled, and the efficiency of inspecting passers-by is thoroughly improved. Strict technical measures are adopted to ensure that the data is accurate and reliable. The system has advanced technology, realizes the high-efficiency prevention of epidemic propagation by using the mobile phone and the AI, and leads the intelligent informatization of epidemic prevention work.
<P>PROBLEM TO BE SOLVED: To provide an aqueous polymeric composition containing selected polymeric nanoparticles.  <P>SOLUTION: The selected polymeric nanoparticle contains at least one multiethylenically unsaturated monomer and at least one water-soluble monomer as polymer units and has an average diameter of 1-50 nm. The aqueous polymeric composition further contains 2nd particles such as pigment particles or 2nd polymer particles. The aqueous polymeric composition is useful for forming a coating having at least one improved property compared with a coating free from the selected polymeric nanoparticle. The aqueous polymeric composition is useful for the treatment of wood. The invention further provides a coating produced by using the aqueous polymeric composition.  <P>COPYRIGHT: (C)2004,JPO
The invention discloses a herbal preservative composition. The composition is characterized by being prepared from a herbal active ingredient with butanediol and pentanediol which are synergized to achieve a bacterium inhibiting effect, wherein the herbal active ingredient comprises xanthoxylum piperitum fruit extract, pulsatilla koreana nakai extract and usnea barbata extract. The invention further discloses a freckle-removing facial mask and a preparation method thereof. The facial mask is prepared from the herbal preservative composition, polyvinyl alcohol crosslinked polymer, ethanol, papain, donkey-hide gelatin, ginseng root extract, herba leonuri extract, licorice root extract, radix sophorae extract, gingko leaf extract, scutellaria baicalensis extract, stephania tetrandra extract, carbomer and deionized water. The herbal preservative composition does not contain conventional chemical preservative, does not irritate human bodies, does not have toxic or side effect, cannot cause allergy, and has a good preservative effect. The herbal preservative composition has the effect of safely removing freckles and prolonging the preservation period of products when being applied to traditional Chinese medicine freckle-removing facial masks.
Notoginseng leaf triterpenes (PNGL), derived from the dried stems and leaves of P. notoginseng, is a phytoestrogen that exerts many neuroprotective effects in vivo and in vitro of ischemic stroke. However, its impact on neurological restoration specifically in relation to angiogenesis following ischemic stroke remains unexplored. The aim of this study was to assess the effects of PNGL on angiogenesis subsequent to ischemic stroke. Male Sprague-Dawley rats were utilized in this study and were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). Post-ischemia, PNGL were administered through intraperitoneal (i.p.) injection. The high-performance liquid chromatography (HPLC) fingerprinting, triphenyltetrazolium chloride (TTC) staining, immunofluorescent staining, network pharmacology and western blot analyses were assessed to determine the therapeutical effect and molecular mechanisms of PNGL on cerebral ischemia/reperfusion injury. Our findings demonstrate that PNGL effectively reduced infarct volume, enhanced cerebral blood flow, and induced angiogenesis in rats subjected to MCAO/R. Notably, PNGL also facilitated neuronal proliferation and migration in HUMECs in vitro. The proangiogenic effects of PNGL were found to be linked to the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the AMPK/SIRT1-mediated PGC-1/ERα axis, as well as the activation of neurological function. Our study provides evidence that PNGL hold promise as an active ingredient of inducing proangiogenic effects, potentially through the activation of the Nrf2 pathway and the AMPK/SIRT1-mediated PGC-1/ERα axis. These findings contribute to the understanding of novel mechanisms involved in the restoration of neurological function following PNGL treatment for ischemic stroke.
<P>PROBLEM TO BE SOLVED: To provide a non-human knockout animal whose blood hyaluronic acid concentration is increased, having cancer metastasis inhibiting action, which is a non-human knockout animal that is deficient in Stabilin 2 (Stab 2) gene, and to provide a method for manufacturing the animal, and to provide a screening method of a candidate material for a blood hyaluronic acid increasing agent aiming at Stabilin 2 or a cancer metastasis inhibitor.  <P>SOLUTION: In a Stabilin 2-deficient mouse, it is found that liver non-parenchymal cells cannot incorporate hyaluronic acid, and that a hyaluronic acid level in serum is markedly increased. In addition, it is found that lung metastasis of melanoma and lung cancer is markedly decreased in the Stabilin 2-deficient mouse. Furthermore, it is found that the hyaluronic acid level in serum is increased by administration of Stabilin 2 added with an anti-Stabilin 2 antibody in the mouse, to thereby suppress lung metastasis. The results show that Stabilin 2 is a main clearance receptor to hyaluronic acid, and that metastasis has a reverse correlation to the hyaluronic acid level in serum; and it is suggested that Stabilin 2 is a new target for developing a treatment method toward intervention of tumor metastasis.  <P>COPYRIGHT: (C)2011,JPO&INPIT
BACKGROUND AND PURPOSE: Concerns over chest wall toxicity has led to debates on treating tumors adjacent to the chest wall with single-fraction stereotactic ablative radiotherapy (SABR). We performed a secondary analysis of patients treated on the prospective iSABR trial to determine the incidence and grade of chest wall pain and modeled dose-response to guide radiation planning and estimate risk.
MATERIALS AND METHODS: This analysis included 99 tumors in 92 patients that were treated with 25 Gy in one fraction on the iSABR trial which individualized dose by tumor size and location. Toxicity events were prospectively collected and graded based on the CTCAE version 4. Dose-response modeling was performed using a logistic model with maximum likelihood method utilized for parameter fitting.
RESULTS: There were 22 grade 1 or higher chest wall pain events, including five grade 2 events and zero grade 3 or higher events. The volume receiving at least 11 Gy (V11Gy) and the minimum dose to the hottest 2 cc (D2cc) were most highly correlated with toxicity. When dichotomized by an estimated incidence of ≥ 20 % toxicity, the D2cc > 17 Gy (36.6 % vs. 3.7 %, p < 0.01) and V11Gy > 28 cc (40.0 % vs. 8.1 %, p < 0.01) constraints were predictive of chest wall pain, including among a subset of patients with tumors abutting or adjacent to the chest wall.
CONCLUSION: For small, peripheral tumors, single-fraction SABR is associated with modest rates of low-grade chest wall pain. Proximity to the chest wall may not contraindicate single fractionation when using highly conformal, image-guided techniques with sharp dose gradients.