anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Vaccines against B. pertussis are prepared from isolated cell wall material from B. pertussis which has been treated in aqueous suspension with a C1-C5 water-miscible monohydric alcohol, aldehyde, or ketone at room temperature or below.  The preferred agent is acetone, used at -20 DEG C for 18-24 hours.  The bacteria are cultured on a conventional medium, harvested, suspended in cold water, and ruptured by explosive decompression using pressures of 15,000 to 50,000 p.s.i.  The cell walls are sedimented in a centrifuge, washed, and treated with the above-mentioned agent, washed again, homogenised and suspended in cold distilled water, to which a preservative, such as thimerosal, benzethonium chloride, benzyl alcohol, or g -picolinium chloride may be added, to provide a vaccine.  The vaccine may alternatively be an adjuvant vaccine, prepared by flocculating the distilled-water-suspended cell walls with alum, or by absorbing them on alumina, aluminium phosphate, or hydroxide.  Also other antigens, such as diphtheria or tetanus, may be added to give polyvalent vaccines.
The efficacy and safety of tavaborole topical solution was evaluated in two multicenter, double-blind, randomized, vehicle-controlled trials. Tavaborole topical solution or vehicle was applied once daily for 48 weeks in subjects with 20% to 60% clinical involvement of the target toenail, without dermatophytomas or lunula (matrix) involvement.

A total of 1194 subjects (795 tavaborole, 399 Vehicle) 18 to 88 years of age, 82% male, 84% white, participated in these two trials. Efficacy assessments were made at 52 weeks following a 48-week treatment period.

The Complete Cure efficacy endpoint included negative mycology (negative KOH wet mount and negative fungal culture) and Completely Clear Nail (no clinical evidence of onychomycosis as evidenced by a normal toenail plate, no onycholysis, and no subungual hyperkeratosis). Efficacy results from the two trials are summarized in Table 2.
All participants complete six weeks of TMS treatment (five days per week) within the UCLA TMS Clinic. Participants in this condition additionally access educational materials about mental health and attend a weekly session for 30 minutes with a trained mental health coach to discuss educational content.
Screening for cervical cancer (CCU) is based on a well-codified, organized national screening program. However, unlike breast cancer or colorectal cancer, there is no personalized screening for patients said identified to be at higher risk of developing UCC. In addition, other cancers linked to HPV (papillomavirus), oropharynx and anal, were excluded from this screening, including for high-risk patients. However, in France, HPV-related cancers in the majority of cases concern the cervix (44%), but the anal (24%) and oropharynx (22%) locations can no longer be neglected. An increase of more than 200% in the incidence of oropharyngeal cancer was reported in the United States between 1988 and 2004. There appears to be a significant association between certain some sexual habits and the risk of multi-site HPV (+) carcinoma. However, several studies suggested that multi-site transmission could involve simple self-inoculation. Therefore, the investigators are interested in a population particularly at risk of developing these viro-induced cancers: patients chronically infected with HPV who will also be those likely to develop multi-site lesions. It is established that high risk HPV are more widely involved in CCU, however, the causes of the persistence of these HPV have not been clearly identified.

It therefore seems essential to continue screening for CCU in chronically infected patients, taking into account the multiple possible locations. The characterization of HPV viruses in terms of types, subtypes and co-infections is one of the key elements, determining the risk of persistence and the risk of cancer. Also, the implementation of a multi-site screening associated with a genotyping by high throughput or new generation sequencing (NGS) would make it possible to understand the part of HPV in the persistence of the infection and to detect the development of lesions at other anatomical sites.
Participants randomized to control will be scheduled for 60-minute weekly treatment sessions held over four consecutive weeks focused on problems associated with MOUD, substance use, and general self-management strategies. Importantly, group will explicitly avoid talking about pain coping skills and setting goals for daily step targets.
Closed-loop audiomotor game. Home-based training sessions for 3.5 hours per week over an 8-week. Participants will have high frequency hearing loss.
Parkinson's disease (PD) is a neurodegenerative disease commonly seen in middle-aged and elderly people. The incidence of PD is increasing year by year, which seriously affects the patients' quality of life. Oxidative stress (OS) is one of the pathogeneses of PD. In recent years, with the deepening of research, it has been found that OS is closely related to other PD-related pathogenesis, such as the susceptibility of substantia nigra, mitochondrial dysfunction, abnormal folding of α -synuclein (α -Syn), nitric oxide (NO) increasing, endoplasmic reticulum stress (ERS), decreased antioxidant capacity, etc., which is considered to be the central link of the complex convergence of various pathogenesis. A large number of studies also have shown that acupuncture has great potential in regulating OS and treatment of PD. In the present article, we reviewed the role of OS in PD pathology and the mechanism of acupuncture in the treatment of PD by improving OS in recent years: 1) acupuncture acts on Parkinson's disease by increasing antioxidant enzyme levels, 2) acupuncture works in Parkinson's disease by improving pathways related to OS (Nrf2/ARE, PI3K/Akt), 3) acupuncture acts on Parkinson's disease by improving OS-related neuroinflammation, and 4) acupuncture acts on Parkinson's disease by improving the cerebral-intestinal axis associated oxidative stress.
A method for preparing a computer for use as a central monitoring station includes connecting a computer to a network. An operating system is installed on the computer. Anti-virus software is installed on the computer. Licensing information is installed on the computer. Configuration information is stored on the computer. The configuration information is for the computer and at least one additional computer. A determination is made that the computer is to be activated as a first central monitoring station on the network. When the determination is made that the computer is to be activated as the first central monitoring station, the computer is configured according to a first subset of the configuration information. The computer is activated on the network as the first central monitoring station.
The present invention relates to chitin beads having a uniform and fine particle size and comprising microsporidian spores whose principal cell wall substance is chitin; chitosan beads comprising N-deacetylated chitin and having a uniform fine particle size; methods for preparing these beads; carriers comprising these beads; and a method for preparing microsporidian spores. Microsporidian spores are proliferated in insect's bodies or cultured cells to obtain chitin beads having the uniform and fine particle size and whose cell wall substance is mainly composed of chitin. The chitin as the major cell wall substance is subjected to N-deacetylation to give chitosan beads. When the insect is a larva of domesticated silkworm, microsporidian spores are proliferated by orally or percutaneously inoculating the spores into the 2nd instar domesticated silkworm larvae in a concentration of 5 .times. 10 2 to 5 .times. 10 8 spores/ml, then the proliferated microsporidian spores are isolated from the bodies of the grown 5th instar domesticated silkworm larvae, followed by purifying the resulting spores to give chitin beads having the uniform and fine particle size and chitosan beads can be obtained from the chitin beads in the same manner used above. These beads are used as carriers for the immobilization or encapsulation of a variety of substances such as an antibiotic and a microorganism.
More than 95% of people are infected with varicella Zoster virus (VZV) at one time of life or another. Primary VZV infection manifests as varicella (chicken pox). The virus then establishes a latent infection of the sensory ganglia from which it may reactivate years later to produce the clinical syndrome of Herpes Zoster (shingles). The initial cutaneous VZV lesions are pruritic, erythematous macules; and the lesions progress through maculopapular stage to vesicular, ulceration and crusting phases. The crusting phase signals the beginning of the healing process, and begins with clouding of the vesicular fluid, within about 24 to 48 h after the appearance of each lesion. This is a Phase 2 study to assess: 1) the overall benefit of ARYS-01 (sorivudine) cream 3% vs. Placebo cream (with immediate or delayed use of Valaciclovir therapy) on Herpes Zoster rash healing rates and postherpetic neuralgia (PHN), 2) the efficacy of ARYS-01 cream 3% vs. Placebo cream, prior to initiation of Valaciclovir, to build evidence for monotherapy treatment benefit of ARYS-01 cream on the initial onset of Herpes Zoster symptoms, 3) the efficacy of ARYS-01 cream 3% vs. Placebo cream, with immediate or delayed initiation of Valaciclovir, for synergetic effects on the initial onset of Herpes Zoster symptoms.

The primary efficacy endpoint is the effect of ARYS-01 cream (with or without Valaciclovir) on the reduction of the crusting stage of VZV rash present at Day 8. Secondary endpoints include time to cessation of new lesion formation, and time to cessation of Zoster-associated pains, pain intensity, rash healing and size reduction, and lesion dissemination.
Bariatric patients are at risk for developing biliary stones. Choledocholithiasis poses a significant challenge in Roux-en-Y gastric bypass patients due to anatomical changes, complicating the treatment. We present a case of a 71-year-old female with recurrent choledocholithiasis post-bariatric surgery. After failed endoscopic attempts, a biliodigestive bypass with choledocoduodenal anastomosis was performed successfully using the Da Vinci robotic platform. This technique offers a single anastomosis, excluding the duodenum from transit, preventing food reflux. The patient had an uneventful recovery with no recurrence after 1 year. The choledocoduodenal anastomosis is a viable option for biliary diversion in patients with challenging endoscopic access post-gastric bypass, offering favorable outcomes.
Participants in the NucleoCapture treatment arm will receive Standard of Care plus three treatment sessions with the NucleoCapture treatment device. The device consists of 100ml NucleoCapture selective adsorber.
PCT No. PCT/DK86/00081 Sec. 371 Date Mar. 18, 1987 Sec. 102(e) Date Mar. 18, 1987 PCT Filed Jul. 14, 1986 PCT Pub. No. WO87/00834 PCT Pub. Date Feb. 12, 1987.This invention relates to vitamin D analogues represented by the general formula I   <IMAGE> I  in which formula X stands for hydrogen, lower alkyl, halogen or hydroxy; Y stands for hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for lower alkyl, optionally substituted with halogen or hydroxy with the proviso that R1 and R2 cannot both be methyl when X is other than lower alkyl, or, taken together with the carbon atom numbered 25, R1 and R2 can form a saturated or unsaturated C3-C9 carbocyclic ring which may optionally be substituted at any possible position(s) with lower alkyl, halogen or hydroxy; R3 stands for hydrogen or lower alkyl; R4 and R5 represent either each hydrogen, or when taken together constitute a bond, with the result that a double bond connects carbon atoms numbered 22 and 23; and bioreversible derivatives thereof. The compounds of the invention have a favorable therapeutic index and are particularly useful in the treatment of human and veterinary disorders which are characterized by abnormal cell proliferation and/or cell differentiation.
OBJECTIVE: To investigate the benefits and drawbacks of breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap for breast cancer and treatment experience of postoperative operation-related complications.
METHODS: A retrospective analysis was performed on clinical data of 26 female patients with breast cancer who met the selection criteria between September 2021 and March 2023 aging 48.7 years (range, 26-69 years). All tumors were unilateral, with 17 on the left side and 9 on the right side. The tumor size ranged from 1.0 to 7.0 cm, with an average of 2.7 cm. The pathological staging included T 1 in 11 cases, T 2 in 14 cases, and T 3 in 1 case; N 0 in 10 cases, N 1 in 11 cases, N 2 in 2 cases, and N 3 in 3 cases; no distant metastasis (M 0) occurred when first diagnosed. Among them, 10 cases underwent breast conserving surgery, and 16 cases underwent nipple-sparing mastectomy. All patients underwent breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap. The operation time, incision length, and postoperative drainage volume in 3 days were recorded. Breast-Q "Satisfaction with back" scale was conducted to evaluate patients' satisfaction with back at 6 months after operation.
RESULTS: The operation time was 280-480 minutes (mean, 376.7 minutes), the incision length was 10-15 cm (mean, 12.2 cm), the postoperative drainage volume in 3 days was 500-1 600 mL (mean, 930.2 mL). There were 4 cases of postoperative seroma, 1 case of incision rupture, 1 case of paresthesia of the thoracic wall, and 1 case of edema of the ipsilateral upper limb. All patients were followed up 12-30 months (mean, 20.1 months). No latissimus dorsi muscle flap necrosis, latissimus dorsi muscle atrophy, or shoulder joint dysfunction occurred during follow-up; 2 patients had recurrence of lymph nodes in the ipsilateral axilla after operation, but no distant metastasis occurred. Breast-Q score at 6 months after operation was 64-100 (mean, 79.5). The average score was 78.6 (range, 64-100) in patients underwent nipple-sparing mastectomy and 81.0 (range, 78-100) in patients underwent breast conserving surgery.
CONCLUSION: Breast reconstruction with endoscopic-assisted harvesting of the latissimus dorsi muscle flap for breast cancer is proven to be a surgical approach with safety and cosmetic effects with mild postoperative operation-related complications and considerable patient satisfaction.
Pulmonary hypertension (PH) is a devastating disease characterized by vascular remodeling, resulting in right ventricular failure and death. Dysregulation of energy metabolism is linked to PH pathogenesis. Trimetazidine (TMZ), a selective long-chain 3-ketoacyl coenzyme A thiolase inhibitor, is critical in maintaining energy metabolism. Despite the indicated TMZ's inhibitory effect on pulmonary vascular remodeling in PH development, the integrated evaluation of the changes in biomolecules, such as metabolites and transcripts, that TMZ induces in the lung and heart tissues is largely unknown in vivo. For an improved understanding of the molecular mechanism involving the effects of TMZ on PH development, we performed a comprehensive analysis of the changes in cardiac metabolites and pulmonary transcripts of SU5416-Hypoxia (Su/Hx) rats treated with TMZ. Metabolomic analysis of the Su/Hx-induced PH hearts demonstrated that TMZ reduced the long-chain fatty acid concentration. Additionally, TMZ alleviated PH degree and excessive strain on the right heart functions in rats with Su/Hx-induced PH. We identified the candidate target genes for TMZ treatment during PH development. Interestingly, the mRNA levels of the fatty acid transporters were substantially downregulated by TMZ administration in the lungs with Su/Hx-induced PH. Notably, TMZ suppressed excessive proliferation of human pulmonary artery smooth muscle cells under hypoxic conditions. Our study suggests that TMZ ameliorates PH development by involving energy metabolism in the lungs and heart.
TAK-438 20 mg, tablets, orally, once on Day 1 and twice daily on Days 3-9. Participants were asked to fast for a minimum of 10 hours prior to breakfast, followed by administration of assigned treatment 0.5 hours after breakfast and dinner.
Participants will receive 25mg oral psilocybin one day to two weeks after baseline psychophysical and fMRI testing. Psychophysical and fMRI testing will then be employed one day to two weeks after drug administration.
PURPOSE:To provide a vehicle containing a maltitol difatty acid ester as the main film component, capable of ready production at low cost, excellent in stability, useful in the fields of medicine, cosmetic and food and suitable for a vehicle preparation such as a microcapsule. CONSTITUTION:Maltitol is dissolved in dimethyl sulfoxide and a fatty acid ester such as methyl stearate and potassium carbonate are added thereto with stirring. The resultant mixture is allowed to react at 90 deg.C under 35mmHg for 2hr and the obtained reaction product is purified through silica gel chromatography to obtain a maltitol difatty acid ester. This compound as a vehicle forming agent is added to 2wt.% aqueous arbutin solution, sufficiently swollen at 70 deg.C, treated with Polytlon(R), etc., for 1min and immediately cooled to 25 deg.C. Thereby, an arbutin-including vehicle is prepared followed by get filtration treatment for purification. Thus, the stable vehicle composed of a microcapsule, etc., useful in the fields of medicine, cosmetic, food, etc., can be readily produced at low cost.
The invention provides a traditional Chinese medicine composition for treating bone fracture. The traditional Chinese medicine composition mainly comprises drynaria baronii, safflower, divaricate saposhnikovia roots, angelica dahurica, arisaema consanguineum schott, hirudo, frankincense, myrrh, radix cyathulae, Himalayan teasel roots, pyritum, whole angelica sinensis, resina draconis and forsythia. The traditional Chinese medicine composition has effects of relieving inflammation, easing pain, relaxing muscles, stimulating blood circulation, removing stasis and swelling, clearing away heat and toxic materials, accelerating bone formation and the like. Swelling of a wounded part of a wounded person suffering from mild bone fracture is removed and the wounded person does not feel painful after the wounded person uses the traditional Chinese medicine composition for 2-3 days, the wounded person can move freely after using the traditional Chinese medicine composition for 7-8 days, and a wounded person suffering from severe bone fracture can move freely after using the traditional Chinese medicine composition for about 15 days. Besides, the traditional Chinese medicine composition is good in healing effect, and relapse is difficult. In addition, various raw materials of the traditional Chinese medicine composition are easy to obtain and low in cost, a preparation process is simple and is easy to operate, and the traditional Chinese medicine composition is easy to popularize and high in curative effect, and becomes effective fast.
A system for managing a supply of breast milk is disclosed. In one form, the system includes a coded container for receiving expressed breast milk. The computing device receives an image of expressed breast milk in the encoded container. The coding enables the software to identify the size and type, as well as the scale and orientation, of the container and convert the image into an accurate volume. The breastmilk data is then processed and analyzed to generate feedback, such as a record, chart, or prompt, regarding the pumping session. In other embodiments, nipple positioning may also be analyzed.
After general anesthesia and before the beginning of surgery, 20 ml of 0,375% Levobupivacaine are used in Ultrasound-guided Tranversus Abdominis Plain Block. In this group 4 mg of dexamethasone are injected intravenously.
Atrial fibrillation ablation with pulmonary vein ablation and roof line. In addition, complex fractionated atrial electrograms ablation will be performed, lasting at most 30 minutes.
Globally, the primary causes of mortality and morbidity related to kidney ailments can be classified as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). Biomarker detection can have great potential to improve survival, lower mortality, and reduce the cost of treatment of kidney diseases. Considering the chronic nature of CKD, non-invasive identification and monitoring have proven to be useful. Biosensors and more specifically lateral flow test strips (LFTs) are regarded as the most desirable point-of-care instruments which have shown promise in elevating the healthcare industry to a new level. The major aspects of an ideal point-of-care (POC) lateral flow test include its cost effectiveness, high sensitivity and specificity, ease of use, quick result delivery, and quality control. This review provides a detailed account of recent developments, challenges, and opportunities in renal biomarker detection using LFTs including various approaches for sensitivity enhancement along with potential future advancements in POC and LFT kits.
Patients with diabetes type 1 and type 2 older than 21 years of age, in the specialized clinic of Kowsar Hospital (Semnan University of Medical Sciences) are examined. Eligible individuals enter the study and are randomly assigned to group 1 or group 2. In each group, visual acuity measurement, slit lamp biomicroscopy and fundus examination are performed. Intraocular pressure is measured with Goldmann applanation tonometer. pupil size, refraction and keratometry are measured with two different autorefractokeratometers. keratometry, pupil size and other anterior chamber parameters are also evaluated by Oculus Pentacam imaging. Then, the patients receive tropicamide 0.5% drops in group 1 and tropicamide 1% drops in group 2. 30 minutes later, all previous measurements are repeated. Patients and the ophthalmologist and the data analyzer are unaware of the drug type.
Liver fibrosis commences with liver injury stimulating transforming growth factor beta (TGFβ) activation of hepatic stellate cells (HSCs), causing scarring and irreversible damage. TGFβ induces expression of the transcription factor Forkhead box S1 (FOXS1) in hepatocytes and may have a role in the pathogenesis of hepatocellular carcinoma (HCC). To date, no studies have determined how it affects HSCs. We analyzed human livers with cirrhosis, HCC, and a murine fibrosis model and found that FOXS1 expression is significantly higher in fibrotic livers but not in HCC. Next, we treated human LX2 HSC cells with TGFβ to activate fibrotic pathways, and FOXS1 mRNA was significantly increased. To study TGFβ-FOXS1 signaling, we developed human LX2 FOXS1 CRISPR KO and scrambled control HSCs. To determine differentially expressed gene transcripts controlled by TGFβ-FOXS1, we performed RNA-seq in the FOXS1 KO and control cells and over 400 gene responses were attenuated in the FOXS1 KO HSCs with TGFβ-activation. To validate the RNA-seq findings, we used our state-of-the-art PamGene PamStation kinase activity technology that measures hundreds of signaling pathways nonselectively in real time. Using our RNA-seq data, kinase activity data, and descriptive measurements, we found that FOXS1 controls pathways mediating TGFβ responsiveness, protein translation, and proliferation. Our study is the first to identify that FOXS1 may serve as a biomarker for liver fibrosis and HSC activation, which may help with early detection of hepatic fibrosis or treatment options for end-stage liver disease.