anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a construction method, an intervention target and application of a fetal osteoarthritis model caused by prednisone exposure during pregnancy. circGtdc1 is a newly identified circRNA, which changes most significantly in dysplastic cartilage caused by prednisone exposure during pregnancy. RNase R, acD and Sanger sequencing confirmed their cyclization. Prednisolone concentration-dependent decreases circGtdc1 expression in chondrocytes. Silencing circGtdc1 can obviously inhibit chondrocyte proliferation and matrix synthesis gene expression, while overexpression of circGtdc1 has opposite effects and can reverse the effect of prednisolone. The injection of AAV-circGtdc1 over-expression circGtdc1 into the joint cavity can reverse the cartilage dysplasia caused by prednisone exposure during pregnancy. The intervention target established by the invention is novel, reliable and simple, and provides possibility for early prevention and treatment of fetal osteoarthritis.
Trasdiagnotic cognitive-behavioral group therapy: The psychological interventions will be manualized. Patients assigned to the experimental group will receive 7 sessions (1.5 hr/session) in groups of approximately 8-10 individuals over a 12 week period.
Blast-related traumatic heterotopic ossification (tHO) impacts clinical outcomes in combat-injured patients, leading to delayed wound healing, inflammatory complications, and reduced quality of life. Blast injured patients often have significant burns. This study investigated whether a partial thickness thermal burn injury exacerbates blast-related tHO in a clinically relevant polytrauma animal model. Adult male Sprague Dawley rats were subjected to an established model involving a whole-body blast overpressure exposure (BOP), complex extremity trauma followed by hind limb amputation (CET) followed by the addition of a 10 % total body surface area (TBSA) second degree thermal burn (BU). Micro-CT scans on post-operative day 56 showed a significant increase in HO volume in the CET + BU as compared to the CET alone injury group (p < .0001; 22.83 ± 3.41 mm3 vs 4.84 ± 5.77 mm3). Additionally, CET + BU concomitant with BOP significantly increased HO (p < .0001; 34.95 ± 7.71 mm3) as compared to CET + BU alone, confirming BOP has a further synergistic effect. No HO was detectable in rats in the absence of CET. Serum analysis revealed similar significant elevated (p < .0001) levels of pro-inflammatory markers (Cxcl1 and Il6) at 6 h post-injury (hpi) in the CET + BU and BOP + CET + BU injury groups as compared to naïve baseline values. Real-time qPCR demonstrated similar levels of chondrogenic and osteogenic gene expression in muscle tissue at the site of injury at 168 hpi in both the CET + BU and BOP+CET + BU injury groups. These results support the hypothesis that a 10 % TBSA thermal burn markedly enhances tHO following acute musculoskeletal extremity injury in the presence and absence of blast overpressure. Furthermore, the influence of BOP on tHO cannot be accounted for either in regards to systemic inflammation induced from remote injury or inflammatory-osteo-chondrogenic expression changes local to the musculoskeletal trauma, suggesting that another mechanism beyond BOP and BU synergistic effects are at play. Therefore, these findings warrant future investigations to explore other mechanisms by which blast and burn influence tHO, and testing prophylactic measures to mitigate the local and systemic inflammatory effects of these injuries on development of HO.
To support causal inference, the investigators will also sample Veterans without COVID who are matched to participants with COVID-19. In general, cases will be compared to comparators matched on risk of developing COVID infection during a given wave.
A method includes receiving an objective sleep score associated with a user. The method also includes presenting a subjective sleep prompt. The method also includes receiving, via a user input device, a subjective sleep score. The method also includes comparing the objective sleep score with subjective sleep score. The method also includes determining, based on the comparison of the objective sleep score and the subjective sleep score, that the subjective sleep score does not correspond to the objective sleep score. The method also includes presenting one or more additional prompts, wherein the one or more additional prompts are associated with sleep quality factors. The method also includes receiving responses to the one or more additional prompts. The method also includes determining, based on the responses to the one or more additional prompts, a sleep recommendation for the user. The method also includes presenting the sleep recommendation to the user.
In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely associated with administration of HYZAAR.

Creatinine, Blood Urea Nitrogen: Minor increases in blood urea nitrogen (BUN) or serum creatinine were observed in 0.6 and 0.8 percent, respectively, of patients with essential hypertension treated with HYZAAR alone. No patient discontinued taking HYZAAR due to increased BUN. One patient discontinued taking HYZAAR due to a minor increase in serum creatinine.

Hemoglobin and Hematocrit: Small decreases in hemoglobin and hematocrit (mean decreases of approximately 0.14 grams percent and 0.72 volume percent, respectively) occurred frequently in patients treated with HYZAAR alone, but were rarely of clinical importance. No patients were discontinued due to anemia.

Liver Function Tests: Occasional elevations of liver enzymes and/or serum bilirubin have occurred. In patients with essential hypertension treated with HYZAAR alone, no patients were discontinued due to these laboratory adverse experiences.

Serum Electrolytes: See PRECAUTIONS.
This research is a cross-sectional survey research, using the method of network survey, with domestic emergency medicine medical staff as the research object. Inclusion criteria: 1) Emergency medical staff who have a Chinese medical practitioner certificate or a nurse practitioner certificate and are within the valid registration period; 2) Agree to participate in this study. Exclusion criteria: incomplete questionnaires. The questionnaire was designed for the "Survey of Current Status of Marrow Cavity Pathway Cognition of Medical Staff in Emergency Department", including three parts: (1) general information of the survey object; (2) cognition and use status of IO; (3) clinical application of IO Attitude. Based on the "Questionnaire Star" platform, questionnaires are distributed through various emergency-related academic organizations. The front page of the questionnaire clearly marked the reminder of voluntary participation in the survey and related declarations, and it could be filled out after informed consent.
Disclosed are a holding device for an item to be measured, a holding device for living organisms and an optical measuring device which allow smooth measurement when optical tomographic information is obtained with a living organism as the item to be measured. A specimen holder (64) which is used as the holding device for an item to be measured is formed from a material which has optical propagation properties while scattering near infrared light and fluorescent light isotropically. In addition, the specimen holder (64) can be divided into block (66) and block (68) at faces containing the axial centre. The blocks (66, 68) are provided with concave parts (66A, 68A) which match the outer shape and size of the specimen. The specimen (18) is accommodated in such a way that the epidermis is intimately in contact with the cavity which is formed by these concave parts (66A, 68A). In this way, the specimen holder (64) holds the specimen (18) in such a state that the original shape of the specimen (18) and the positions of the internal organs thereof are maintained during measurement.
BACKGROUND: Candida auris, a multidrug-resistant fungal pathogen, has received considerable attention owing to its recent surge, especially in South America, which coincides with the ongoing global COVID-19 pandemic. Understanding the clinical and microbiological characteristics of outbreaks is crucial for their effective management and control.
OBJECTIVE: This retrospective observational study aimed to characterize a C. auris outbreak at a Peruvian referral hospital between January 2021 and July 2023.
METHODS: Data were collected from hospitalized patients with positive C. auris culture results. Microbiological data and antifungal susceptibility test results were analysed. Additionally, infection prevention and control measures have been described. Statistical analysis was used to compare the characteristics between the infected and colonized patients.
RESULTS: Thirty-three patients were identified, mostly male (66.7%), with a median age of 53 years. Among them, 18 (54.5%) were colonized, and 15 (45.5%) were infected. Fungemia was the predominant presentation (80%), with notable cases of fungemia in tuberculosis patients with long-stay devices for parenteral anti-tuberculosis therapy. Seventy-five percent of the isolates exhibited fluconazole resistance. Echinocandins were the primary treatment, preventing fungemia recurrence within 30 days. Infected patients had significantly longer hospital stays than colonized patients (100 vs. 45 days; p = .023). Hospital mortality rates were 46.7% and 25% in the infected and fungemia patients, respectively. Simultaneous outbreaks of multidrug-resistant bacteria were documented.
CONCLUSIONS: This study underscores the severity of a C. auris outbreak at a referral hospital in Peru, highlighting its significant impact on patient outcomes and healthcare resources. The high prevalence of fluconazole-resistant isolates, leading to prolonged hospital stay and high mortality rates, particularly in cases of fungemia, underscores the critical need for effective infection prevention and control strategies.
Learning to Breathe (L2B) is an existing, evidence-based program for adolescents that teaches mindfulness skills each week, including time to practice and reflect. the skills are grouped into six themes: Body, Reflections, Emotions, Attention, Tenderness, Habits, and Empowerment.
The invention relates to the technical field of preservatives. The invention provides a composition containing p-hydroxyacetophenone, a preparation method and an application thereof, wherein the composition comprises the following components in parts by weight: 10-40 parts of p-hydroxyacetophenone, 30-70 parts of C3-C8 dihydric alcohol and 1-6 parts of plant extract. The preservative prepared by the composition is safe and efficient, has a wide antibacterial spectrum and good water solubility, and is convenient to use. Not only can be independently used as a preservative system in a cosmetic formula, but also can be used together with the traditional preservative, so that the dosage of the traditional preservative is reduced. Can also be used as a conceptual 'no-additive' raw material and is independently applied to products, and the anti-corrosion effect is good. Meanwhile, harmful substances such as formaldehyde and the like cannot be released in various cosmetics, and the skin care product is mild and does not irritate the skin.
AIMS: Pediatric posterior fossa tumor (PFT) survivors experience long-term cognitive sequelae, including memory disorders, for which irradiation is one of the main risk factors. The aims of the present study were to (1) explore the profile of impairment in episodic, semantic, working and procedural memory systems in irradiated versus nonirradiated PFT survivors, and (2) test whether an autobiographical questionnaire and a two-phase ecological test (Epireal) assessing episodic memory are more sensitive to radiation-induced hippocampal damage than commonly used tests.
MATERIALS AND METHODS: A total of 60 participants (22 irradiated PFT survivors, 17 nonirradiated PFT survivors, and 21 controls) were included in the prospective IMPALA study. They all underwent a broad battery of tests assessing the different memory systems in two 2-day sessions 3 weeks apart. We performed between-groups comparisons and analyzed impairment profiles, using -1.65 SDs as a cut-off. For irradiated patients, correlations were calculated between mean radiation doses to key brain structures involved in memory (hippocampus, cerebellum, and striatum) and corresponding memory scores.
RESULTS: PBT survivors performed significantly more poorly than controls (p < 0.001) on conventional tests of episodic, semantic and working memory: 64% of irradiated patients and 35% of nonirradiated patients had a deficit in at least two memory systems, with episodic memory impairment being more specific to the irradiated group. Epireal had a larger effect size than the other episodic memory tests, allowing us to detect deficits in a further 18% of irradiated patients. These deficits were correlated with the mean radiation dose to the left hippocampus.
CONCLUSION: Memory impairment is a frequent long-term cognitive sequela in PFT survivors, especially after radiation therapy. New ecological tests of episodic memory that are more sensitive to radiation-induced deficits than conventional tests could yield specific markers of the toxicity of medial temporal lobe irradiation.
The present technology provides a nail coating system suitable for improving a nail plate. The nail coating system includes an oil-based serum and a base composition. The nail coating system may further comprise a UV/LED composition. In use, the oil-based serum may be applied directly to a nail plate without first cleaning the nail plate with alcohol and/or acetone. The oil-based serum coat may fill in any crevices in the nail plate and restoring sebum and water on the nail plate. After the oil-based serum layer is buffed into the nail or dried, the base composition may be applied. After the base composition dries, the UV/LED composition may be applied and cured. Next, a user may apply a nail polish and/or a top coat to the UV/LED composition.
The correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate inflammation, are recognized contributors to neoplastic transformation through various mechanisms, including oncogenic mutations, resistance to apoptosis, and adaptive responses like angiogenesis. This review aims to establish connections between the intricate and complex mechanisms of chronic inflammation and cancer. We illuminate implicit signaling mechanisms that drive the association between chronic inflammation and the initiation/progression of cancer, exploring potential impacts on other diseases. Additionally, we discuss the modalities of currently available therapeutic options for chronic inflammation and cancer, emphasizing the dual nature of such therapies. A thorough understanding of the molecular basis of chronic inflammation is crucial for developing novel approaches in the prevention and treatment of cancer.
PURPOSE:To provide a cholesterol-lowering substance composed of wheat bran having particle size smaller than a specific level, having excellent activity to decrease cholesterol level in blood and applicable safely without lowering the physiological action such as prevention of constipation. CONSTITUTION:For example, wheat bran is washed with water, dried in air, crushed and classified. A fraction having a particle size finer than 60 mesh is collected and used as the objective substance for lowering cholesterol level. It is administered orally preferably in the form of a solid, however, it may be used as an additive for food. The effect can be increased by increasing the administration dose. It can be administered extremely safely without causing side effect.
Materials and Method: Thirty-three patients with CTS (mild to moderate) were included to randomized, single-blind, controlled clinical trial. Based on EMG results and clinical examination, patient group was divided two part as mild and moderate CTS (group 1) and normal (group 2). The Sick Boston Carpal Tunnel Syndrome Questionnaire form was filled in face-to-face method.

Cases in this study: Patients who had pain and numbness problems at the hands of the Bezmiâlem Vakif University Polyclinic for Women and Obstetrics were then directed to the Bezmiâlem Vakif University Physical Therapy Rehabilitation Policlinic. After the examination and clinical testing of each patient (Tinel test, Phalen's test, Reverse Phalen's and Durkan's Carpal Compression test), the patients were directed to Bezmiâlem Vakif University Neurology Policlinic. Based on electromyography (EMG) results and clinical examination, the group was classified as mild and moderate CTS (group 1) and normal (group 2). A disease exercise form was distributed for all patients to do exercises.
No obstruction (FEV1/FVC\<70). Controls will be recruited after each case and will be matched by: age (±5 year), 2) gender, 3) smoking (±5 pack-year) and 4) BMI (±5).
A process for preparing a microparticulate complex is provided. The process comprises: a) combining a particle-forming component ("PFC") and a nucleic acid-like component ("NAC") in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC  are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50 %  (preferably less than 20 %) of the volume containing free water. Also disclosed composition comprising water and particles of the microparticulate complex. According to the invention a nucleic acid-like is component is delivered to a cell by (a) contacting the cell with a composition comprising water and the microparticulate complex, and (b) maintaining the contact for a time sufficient to allow the nucleic acid-based moiety to enter the cell. A  therapeutic nucleic acid-like component is delivered into a patient in need thereof by administering a composition comprising water and particles of the microparticulate complex. Also disclosed is a charge-changing composition represented by the formula A-X-B, wherein X represents a chemical bond capable of irreversible dissociation in reaction to a factor in a physiological or bioprocess environment; A represents a molecular moiety that upon dissociation of the bond X produces a ionically charged product; and B represents a molecular moiety, which upon the dissociation of bond X, separates from the composition leaving the remaining ionically charged product more positive than that of A-X-B itself.
Joint arthroplasty is an effective surgical intervention, however prosthetic survivorship is finite. New or modified prosthetic components are routinely introduced, partly in an effort to improve survivorship. When new technologies emerge for total knee replacement it is not always evident that they are an improvement over existing options. This determination requires long-term follow-up studies. Conventional studies require a large number of patients and approximately 10 years of follow-up. By using RSA to measure micromotion of prostheses over time problems can be elucidated with a much smaller sample over a shorter time period. RSA involves using tantalum markers (0.5-1.0 mm beads inserted in the bone and prosthesis during surgery) to measure motion in subsequent bi-planar x-rays of the joint. The relatively new Medial Pivot Knee (ADVANCE Knee) theoretically reproduces the natural kinematics of the knee but it is unclear what effect this design may have on the forces applied to the tibial component-bone interface. The amount of micromotion of the tibial component is directly related to the amount of force exerted on it and inversely related to its fixation. In this study we propose to compare in vivo micromotion at the tibial component-bone interface with the ADVANCE Medial-Pivot Knee (experimental group) versus a more conventional prosthesis (control), the ADVANCE Traditional Knee. Patients (n=60; age 45-80 years old) with primary osteoarthritis of the knee and mono-articular disease will be randomized to receive either the ADVANCE Traditional or ADVANCE Medial-Pivot Knee using Simplex cement. Eight tantalum markers will be placed in both the tibia and femur proximal to the prosthesis and in the polyethylene tray of the tibial component. Pre-operatively and at 6, 12 and 24 months all patients will complete general health (SF-12) and joint specific questionnaires (Oxford -12 Item Knee Score), have their body mass index calculated, and have the range of motion, alignment, extensor function and ligamentous competency of their index knee recorded. On the first weight-bearing day after surgery bi-planar standing x-rays will be taken and used as a reference point for tibial component position. At 6, 12 and 24 months post-operatively patients will undergo more bi-planar standing x-rays incorporating provocative loading tests. Micromotion will be analyzed through serial comparison of digital x-rays by blinded study personnel using RSA software. Parametric statistics (unpaired Student's t-test) will be used to compare the 2 groups.
A morphone or non-crystalline nystatin (fungicidin) is rendered water soluble by the incorporation in the composition of an anionic surfactant.  Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-ter-octylphenoxy ethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used.  The ratio of nystatin to the anionic surfactant may vary between 1 : 1.5 and 1 : 5 parts by weight.  In the preferred process for producing the solubilized nystatin, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried.  Specifications 714,189, 796,512 and U.S.A.  Specifications 2,115,192 and 2,628,187 are referred to.ALSO:Amorphous or non-crystalline nystatin (fungicidin) is rendered water-soluble by the incorporation in the composition of an anionic surfactant.  Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-teroctylphenoxyethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used.  The ratio of nystatin to the anionic surfactant may vary between 1 : 0.5 and 1 : 5 parts by weight.  The compositions may be incorporated in tablets, vaginal suppositories or in ointments, especially ointments having a base formed of polyethylene and a mineral oil. In the preferred process for producing the solubilized nystatin compositions, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried. Specifications 714,189, 796,512, [both in Group IV (b)], and U.S.A. Specifications 2,115,192 and 2,628,187 are referred to.