anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIM: The objective of this study was to assess the predictive performance of net water uptake (NWU) based on the Alberta stroke program early CT score (ASPECTS) from different ASPECT regions in relation to the development of malignant middle cerebral artery (MCA) infarction.
MATERIAL AND METHODS: Patients with acute ischemic stroke (AIS) of the MCA territory were retrospectively enrolled between January 2019 and July 2022. Patients were divided into two groups according to the follow-up CT after 24-48 hours: malignant and nonmalignant infarction. NWUs were measured on diverse ASPECT regions on admission non-contrast CT, namely affected ASPECTS-NWU (af-ASPECTS-NWU), subcortical ASPECTS-NWU (sc-ASPECTS-NWU), and cortical ASPECTS-NWU (c-ASPECTS-NWU). Baseline characteristics were collected for univariate analyses and multivariate regression analyses to explore the independent risk factors for malignant infarction. Receiver operating characteristic (ROC) curves were plotted and compared.
RESULTS: patients were included in the final analysis. Malignant MCA infarction was achieved in 42 (27.45%) patients and nonmalignant was 111 (72.55%). Compared with the nonmalignant infarction group, higher baseline National Institute of Health stroke scale (NIHSS) score, af-ASPECTS-NWU, c-ASPECTS-NWU, sc-ASPECTS-NWU, and lower ASPECTS were noted in the malignant infarction group (all P < 0.001). Multivariate logistic regression showed that only baseline sc-ASPECTS-NWU (>3.6%) was a positive factor for malignant MCA infarction. The ROC analysis indicated the highest predictive value of sc-ASPECTS-NWU for indicating malignant infarction with the area under ROC curve (AUC) 0.91.
CONCLUSION: Higher baseline sc-ASPECTS-NWU was a quantitative predictor for malignant MCA infarction in patients with AIS, which could be helpful for treatment decisions.
The invention discloses a quality control method for orthopedics-traumatology coaptation. The method adopts TLC to carry out qualitative identification for notoginseng, borneol, safflower and Nux vomica powder and uses electrophoresis for carrying out qualitative identification for starfish. HPLC and GC are respectively adopted to carry out quantitative identification for strychnine and the borneol. Chemical titration is adopted to carry out quantitative identification for mercury sulfide. Therefore, the quality control scope of the orthopedics-traumatology coaptation is enlarged. The quality control method for orthopedics-traumatology coaptation is easy to be practiced and has strong specialization. In addition, the quantitative identification has high precision and good repeatability, thus ensuring that the quality of compound medicine is uniform, stable, effective and controllable.
OBJECTIVE: This study aimed to investigate the effects of the presence of subchorionic hematoma (SH) in early pregnancies with threatened miscarriage (TM) on levels of first-trimester maternal serum markers, pregnancy-associated plasma protein-A (PAPP-A), and free β-human chorionic gonadotropin (β-hCG) levels.
METHODS: The data of TM cases with SH in the first trimester between 2015 and 2021 were evaluated retrospectively. The data of age and gestational age-matched TM cases without SH were also assessed to constitute a control group. Demographic characteristics, obstetric histories, ultrasonographic findings, and free β-hCG and PAPP-A levels of the groups were compared.
RESULTS: There were 119 cases in the study group and 153 cases in the control group. The median vertical and longitudinal lengths of the SH were 31 mm and 16 mm. The median age of both groups was similar (p=0.422). The MoM value of PAPP-A was 0.088 (.93) in the study group and 0.9 (0.63) in the control group (p=0.519). Similarly, the MoM value of free β-hCG was 1.04 (0.78) in the study group and 0.99 (0.86) in the control group (p=0.66). No significant relationship was found in the multivariate analysis between free β-hCG MoM, PAPP-A MoM, age, gravida, and vertical and longitudinal lengths of the hematoma (p>0.05).
CONCLUSION: The level of PAPP-A and free β-hCG were not affected by the SH. Therefore, these markers can be used reliably in TM cases with SH for the first-trimester fetal aneuploidy screening test.
The recurrent nature of glioblastoma negatively impacts conventional treatment strategies leading to a growing need for nanomedicine. Nanotherapeutics, an approach designed to deliver drugs to specific sites, is experiencing rapid growth and gaining immense popularity. Having potential in reaching the hard-to-reach disease sites, this field has the potential to show high efficacy in combatting glioblastoma progression. The presence of glioblastoma stem cells (GSCs) is a major factor behind the poor prognosis of glioblastoma multiforme (GBM). Stemness potential, heterogeneity, and self-renewal capacity, are some of the properties that make GSCs invade across the distant regions of the brain. Despite advances in medical technology and MRI-guided maximal surgical resection, not all GSCs residing in the brain can be removed, leading to recurrent disease. The aggressiveness of GBM is often correlated with immune suppression, where the T-cells are unable to infiltrate the cancer initiating GSCs. Standard of care therapies, including surgery and chemotherapy in combination with radiation therapy, have failed to tackle all the challenges of the GSCs, making it increasingly important for researchers to develop strategies to tackle their growth and proliferation and reduce the recurrence of GBM. Here, we will focus on the advancements in the field of nanomedicine that has the potential to show positive impact in managing glioblastoma tumor microenvironment. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
This is a prospective pilot study of fecal microbiota transplantation in pediatric patients with a history of ESC-R Enterobacteriaceae. Subjects who meet inclusion/exclusion criteria and provide written, informed consent will undergo screening studies and provide a pre-FMT stool sample to confirm intestinal carriage of ESC-R Enterobacteriaceae. The FMT will be administered by nasogastric tube in the outpatient setting by trained personnel. The subjects will be monitored for potential adverse events, recurrence of MDRO infections, infections that may be related to FMT, and worsening of existing comorbidities or development of new comorbidities for the 12 months post-FMT with the option of participating in long-term follow-up for up to 5 years post-FMT. Patients will provide stool samples 2 days, 2 weeks, 4 weeks, 8 weeks, 6 months, and 12 months post-FMT. These samples will be testing for ESC-R Enterobacteriaceae.
A total of 25 patients with right cardiac system tumors in the Department of Cardiac Surgery, Beijing Anzhen Hospital from January 2012 to October 2022 were retrospectively included in the study. The preoperative data, and information of surgical treatment and perioperative management on these patients were analyzed and summarized. One patient developed pulmonary embolism and died before surgery, and the other 24 patients (16 males and 8 females) received surgical treatment, with an average age of (44.7±10.2) years (24-74 years). Nine patients were diagnosed with malignant tumors. Among the 24 patients who received surgical treatment, two patients died during the perioperative period, in-situ tumor recurrence was seen in three patients within about 1 year after surgery (two patients died without surgery, and one patient died 3 months after surgery), two patients had distant metastasis, and 17 patients had a good prognosis. Right cardiac system tumors are rare, with a high malignant rate, and the clinical manifestations vary greatly. Active surgical intervention is found to be effective, and the prognosis is closely related to the pathological type and extent of tumor invasion.
Eligible patients on sirolimus or everolimus will be assigned to receive 20 mg of simvastatin once daily for a period of two months. If tolerated, the dosage of simvastatin will be advanced to 40 mg once daily in months 3 and 4.
BACKGROUND: Otitis media (OM) refers to a common clinical ear disease. Noise seriously damages human hearing function. This study aimed to investigate the effects of various noise types on the hearing function of patients who have recovered from mild OM.
MATERIALS AND METHODS: A total of 160 patients with mild OM treated at our hospital from May 2020 to May 2023 were retrospectively selected for this study. Based on clinical data, the patients were divided into the non-noise group (n = 80) and the noise (n = 80) group. The hearing thresholds of the two groups were compared across various noise types at 500, 1000, and 2000 Hz. In addition, the hearing thresholds of the noise group were compared under the same conditions.
RESULTS: The noise group exhibited significantly higher hearing thresholds at 500, 1000, and 2000 Hz than the non-noise group (P < 0.05). Under traffic, urban construction, and industrial noises, the auditory thresholds at 500, 1000, and 2000 Hz in the noise group were significantly higher than those observed under domestic and speech noises (P < 0.05).
CONCLUSION: Noise shows a close relationship with the hearing function of patients with OM. Traffic, urban construction, and industrial noises greatly influence the hearing function of patients who have recovered from mild OM.
People with peripheral artery disease that has severely reduced blood flow in their lower leg are usually treated with surgical bypass. This condition is known as Critical Limb Ischemia or CLI. Over the last decade, advances in techniques and tools have allowed surgeons to more aggressively treat complex cases. Studies have shown successful treatment of CLI with endovascular techniques (less invasive surgical procedures through a small incision for the treatment of vascular disease), including laser atherectomy and angioplasty. Surgical guidelines are not clear as to the best procedure to use for CLI. To the best of our knowledge, a study comparing laser atherectomy and angioplasty has not been done. Laser atherectomy works by releasing ultraviolet light which is absorbed by the plaque in the arteries. This will then get rid of the plaque. Angioplasty is a procedure used to open blocked or narrowed arteries. Currently, it is not known if laser atherectomy has better results than angioplasty.
PROBLEM TO BE SOLVED: To support the diagnosis of doctor by inferring a diagnosed name or a problem from the abnormal impression of patient and extracting the related items of the inferred result to infer the name of disease from the abnormal impression of patient including a main appeal, and to provide related information required for the diagnosis. SOLUTION: A patient information data base 13 manages all the diagnostic information of patient. A normal value dictionary 14 is utilized for a normal value check part 121 and has information such as the upper limit values/lower limit values of examined values, for example. A control processing means 12 has a patient information processing part 120, normal value check part 121 and abnormal impression related item inference part 122. At the normal value check part 121, it is checked while using the normal value dictionary 14 whether any abnormal impression is recognized in the clinical information of patient processed by the patient information processing part 120 or not.  Based on the abnormal impression, the abnormal impression related item inference part 122 infers the diagnosed name or problem while using a distinguish diagnosis dictionary 15 and extracts the item related to the diagnosed name or problem.
Transcatheter mitral valve repair (TMVR) with the MitraClip system is now approved for degenerative and functional mitral regurgitation (MR). Atrial fibrillation (AF) is commonly seen in MR. In our study, we perform a pooled analysis of the existing data to investigate the outcomes of MitraClip in patients with versus without AF. We conducted a systematic search of PubMed, Google Scholar, and SCOPUS databases through December, 2022 for studies comparing the outcomes of TMVR using the MitraClip in patients with preexisting AF versus those without AF. A meta-analysis was performed to investigate the primary outcomes of all-cause mortality and heart failure (HF) hospitalization. Secondary outcomes were cardiovascular mortality, in-hospital mortality, stroke, New York Heart Association class I or II at follow-up, length of hospital stay, and procedural time. A total of 10 studies (n = 24,111; AF = 12,789; no AF = 11,322) were included in the final analysis. Preexisting AF was associated with higher overall all-cause mortality (odds ratio 1.55, 95% confidence interval 1.32 to 1.83, p <0.0002) and higher overall HF hospitalization rate (odds ratio 1.3, 95% confidence interval 1.08 to 1.56, p <0.0154). There was no statistically significant difference in cardiovascular mortality, in-hospital mortality, stroke, length of hospital stay, procedural time, or New York Heart Association class I/II at follow-up comparing AF versus no AF. The presence of AF in patients who underwent TMVR with MitraClip is associated with higher all-cause mortality and HF hospitalization. This should be taken into consideration in the management of MR patients.
The invention relates to a preparation method of total polysaccharide of seabuckthorn and application thereof, the method comprises the steps of mechanically crushing dried mature seabuckthorn fruits, sieving and separating impurities, degreasing with petroleum ether, naturally drying in the air, continuously extracting with a solvent, centrifuging, concentrating, precipitating with absolute ethyl alcohol, centrifuging again, drying the polysaccharide precipitate at 40 ℃, and preparing water-soluble crude polysaccharide. Purifying the crude polysaccharide, deproteinizing respectively, and separating and purifying by ion exchange resin and sephadex to obtain neutral polysaccharide and acidic polysaccharide. The extraction rate of the total crude polysaccharide extracted by the method reaches 10.61%. The polysaccharide part is proved to have antioxidant activity, and free radicals have scavenging ability. The search for new antioxidants from natural plants is a new direction for the development of modern medicine and food industries; the research on the antioxidation of the polysaccharide and the derivatives thereof and the development of new natural antioxidants have important practical significance. The research can provide reference for the application and development of the seabuckthorn polysaccharide in the anti-oxidation and anti-fatigue functional food.
The young, active patient with pain after subtotal meniscectomy represents a troubling clinical situation with limited treatment options. "Post-meniscectomy syndrome" occurs at a rate of 4-25% and is defined as the presence of knee pain and functional limitations due to increased contact stresses and overload of the articular cartilage in a knee compartment, after subtotal or total meniscectomy. Meniscal allograft transplantation (MAT) can have reasonable results for some patients, typically under the age of 50, with no degenerative change, and no, or correctable instability or malalignment. However, MAT is expensive, it is often difficult to access meniscal allograft tissue, and the procedure can be technically challenging for the surgeon. Meniscal scaffolds have been commercially available and examined in small studies in the literature and metanalyses since the early 2000s. Generally, patients have shown clinical improvement with their use, but over time, they have shown signs of radiologic failure (decrease in size of the meniscal scaffold, meniscal extrusion on MRI, or other radiographic changes.) Nonetheless, recent research shows long-term survivorship of a polyurethane scaffold in some, carefully selected patients. While not shown to be chondroprotective, this could serve as a bridge to MAT or arthroplasty.
The invention publishes a kind of art transcription factor controlled by anoxia. It is composed by construction with which GAL4 DNA combines and HIF1alpha active. The invention also publishes the carrier system containing the mentioned transcription factor. The system is composed by two carriers. One is the carrier which is controlled by anoxia and it can active aim genic expression controlled by G5TATA promoter. The other is the carrier that contains G5TATA promoter. The application is also published. Displace different promoters and the capability of gene expression to butt can come true in different anoxia organizes and cells. Different aim genes can be coupled in to preparation therapeutic drug for tumor, ischemia angiocardippathy and arthritis.
Interstitial lung diseases (ILDs) in adults and children (chILD) are a heterogeneous group of lung disorders leading to inflammation, abnormal tissue repair and scarring of the lung parenchyma often resulting in respiratory failure and death. Inherited factors directly cause, or contribute significantly to the risk of developing ILD, so called familial pulmonary fibrosis (FPF), and monogenic forms may have a poor prognosis and respond poorly to current treatments. Specific, variant-targeted or precision treatments are lacking. Clinical trials of repurposed drugs, anti-fibrotic medications and specific treatments are emerging but for many patients no interventions exist. We convened an expert working group to develop an overarching framework to address the existing research gaps in basic, translational, and clinical research and identified areas for future development of preclinical models, candidate medications and innovative clinical trials. In this Position Paper, we summarise working group discussions, recommendations, and unresolved questions concerning precision treatments for FPF.
Patients with non-small cell lung cancer who met the inclusion and exclusion criteria were screened and randomly divided into control group and experimental group. Control group: chemotherapy plus water (at least 3-5 cups per day, 100-120ml per cup), test group: chemotherapy plus green tea (patients drink tea from the beginning to the end of the test, patients drink moderately concentration of green tea 3-5 cups per day, 100-120ml per cup, and the monthly tea consumption is ≥100g. The tea concentration is defined that the amount of tea in the cup after boiling water is 50% or more which is "strong tea", 25% to 50% is "moderately concentrated tea", and less than 25% is "light tea"). The number of days of tea drinking by the patient is greater than or equal to 18 days per chemotherapy cycle.The quality of life of patients was assessed according to the Lung Cancer Quality of Life Scale (FACT-L (4th Edition)) and the Lung Cancer Symptom Scale (LCSS). Pre-chemotherapy quality of life scores were used as baseline. The evaluation was performed once before each chemotherapy, and the final quality of life assessment was performed within 1-4 weeks after the end of the fourth cycle of chemotherapy. A total of 5 quality of life assessments were completed. If the patient's condition progresses during chemotherapy, the assessment endpoint is when the disease progresses. Primary endpoint: Assessment of changes in quality of life (QOL) after chemotherapy according to FACT-L (4th edition). A clinically significant change in the quality of life of lung cancer was defined as a FACT-L score change of ≥6 points from baseline, with \<6 points defined as no clinically significant changes;
This project will test a practical intervention that uses low cost technologies to activate depressed patients' existing social networks for self-management support. The intervention links patients with a "CarePartner" (CP), i.e., a non-household family member or close friend who is willing to support the patient in coordination with the clinician and any existing in-home caregiver (ICG). Through weekly automated telemonitoring, patients report their mood and self-management status, and receive tailored guidance on self-management. The CP receives a corresponding update along with guidance on how to best support the patient's self-management efforts, and the primary care team is notified about clinically urgent situations. The intervention will be tested among depressed primary care patients from clinics serving low-income and underinsured patients, whom the intervention was especially designed to benefit. Specific Aim 1 is to conduct a randomized controlled trial to compare the effectiveness of one year of telemonitoring-supported CP for depression versus usual care (control) on depression severity. Specific Aim 2 is to examine key secondary outcomes (response and remission, impairment, well-being, caregiving burden, healthcare costs) and potential moderators. Specific Aim 3 is to use a mixed-methods approach to enrich our interpretation of the statistical associations, and to discover strategies to enhance the intervention's acceptability, effectiveness, and sustainability. If the intervention proves effective without increasing clinician burden or marginal costs, then its subsequent implementation could yield major public health benefits, especially in medically underserved populations.
PURPOSE:To obtain a cosmetic for preventing dandruff with improved safety to skin by using asparagus plants, their extracts or extraction solutions. CONSTITUTION:At least one selected from asparagus plants, their extracts and their extract solutions is used in an amount of 0.005 to 30wt.% to the subject dandruff-preventing cosmetic. When the cosmetic is applied, the metabolism in the head skin tissue are appropriately balanced to prevent the formation of dandruff and the effect is almost equal to or more excellent than pyrithione zinc. For example, when asparagus is employed, young stems are preferred, and the dried powder can be added to the cosmetic. When, asparagus is extracted with water or a lower aliphatic alcohol, the extract or extract solution may be added as it is. In addition, other usually used components may be added, when needed.
Case group including 100 patients diagnosed with age-related macular degeneration (50 women, 50 men).Demographic data and dietary intake of different food groups were assessed by a standardized interviewer-assisted questionaire with the method of face-to-face interview. The body weight of the individuals were measured with a calibrated electronic scale,anthropometric measurements were measured by the researcher. Participants' dietary intake was assessed using food frequency questionaire (FFQ). The FFQ included 65 food items traditionally consumed in Turkey. Foods were classified into the following food categories: milk and dairy products, meat and meat products, fruits, vegetables, breads and cereals, beverages, and desserts.
The thickeners which are known and necessary for optimum applicational properties of aqueous surfactant formulations have disadvantages with respect to preparation and activity. Thus, for example, polyether esters can only be prepared under reduced pressure, elevated temperature and long reaction times. Electrolytes, for example, only have a thickening action when used in very high concentrations. The novel thickeners do not have these disadvantages. The use as thickeners of products of the reaction of a polyanhydride containing at least 2 anhydride functions with polyglycol ethers of the formula R-O(CHR1-CHR2-O)xH is proposed. These thickeners have a thickening action even when used in concentrations of from 1 to 5% and can be prepared under mild conditions. The use of products of the reaction of a polyanhydride with polyglycol ethers as thickeners in aqueous surfactant solutions.