anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A piezoelectric foaming pump is provided herein. The piezoelectric foaming pump includes a housing having a first opening for receiving a liquid from a liquid container and a piezoelectric element secured to the housing. The piezoelectric element includes a plurality of holes there through. In addition, the housing includes an air inlet. Although the piezoelectric element has holes there through, prior to activating the piezoelectric element, liquid does not pass through the plurality of holes. When the piezoelectric element is energized, liquid passes through the plurality of holes due to the rapid vibration of the piezoelectric element and is dispensed as a foam. Additionally, a piezoelectric foaming pump having a fluid pump chamber; an air pump chamber; a mixing chamber; a piezoelectric element; and an outlet nozzle is disclosed herein. During operation, fluid pumped from the fluid chamber mixes with air pumped from an air chamber in the mixing chamber and the resulting mixture is passed through the piezoelectric element and dispensed out of a nozzle.
The excessive activation of frog eggs, referred to as overactivation, can be initiated by strong oxidative stress, leading to expedited calcium-dependent non-apoptotic cell death. Overactivation also occurs spontaneously, albeit at a low frequency, in natural populations of spawned frog eggs. Currently, the cytological and biochemical events of the spontaneous process have not been characterized. In the present study, we demonstrate that the spontaneous overactivation of Xenopus frog eggs, similarly to oxidative stress- and mechanical stress-induced overactivation, is characterized by the fast and irreversible contraction of the egg's cortical layer, an increase in egg size, the depletion of intracellular ATP, a drastic increase in the intracellular ADP/ATP ratio, and the degradation of M phase-specific cyclin B2. These events manifest in eggs in the absence of caspase activation within one hour of triggering overactivation. Importantly, substantial amounts of ATP and ADP leak from the overactivated eggs, indicating that plasma membrane integrity is compromised in these cells. The rupture of the plasma membrane and acute depletion of intracellular ATP explicitly define necrotic cell death. Finally, we report that egg overactivation can occur in the frog's genital tract. Our data suggest that mechanical stress may be a key factor promoting egg overactivation during oviposition in frogs.
To explore the long term ARV of treatment-experienced patients who have no sign of drug resistance; to explore the long term efficiency and safety and drug sife effects of ARV in HIV/AIDS patients. These patients have taken ARV for approximately 3 years already.
The present invention provides isolated nucleic acid molecules which comprise sequences from the 3' UTR of myelin basic protein (MBP) mRNA. The subject isolated nucleic acid molecules confer properties such as localization, transport and increased translational efficiency of a heterologous mRNA transcript when transcribed into such mRNA. The present invention also provides vectors comprising the subject isolated nucleic acids. The vectors are useful for increasing translational efficiency of mRNA transcripts produced by a heterologous gene incorporated therein. Also provided by the present invention are methods for increasing translation of a heterologous gene. The methods comprise transforming a eukaryotic cell with at least one of the subject vectors having coding sequence for a heterologous gene. Methods for enhancing gene therapy are also provided.
In recent years musculoskeletal related problems are the leading cause of discomfort in people worldwide. Chronic neck pain is among the most commonly reported problems to physicians. Even before reporting to clinics there is long history of using over the counter pain killers. For the duration of rehabilitation in patients who are suffering from chronic neck pain, exercising has been considered one of the maximum proof-based modalities. Rehabilitation exercises that aim to return functionality of the scapular muscles are deemed necessary to render a successful result on chronic neck pain. In previous researches no one explains the specific treatment protocol in scapular exercises. The current study has compared the effects of scapular stabilization exercises and scapular functional exercises protocol and also compare which is more effective for chronic neck pain.
No sealant was performed. Children received instructions on how to brush their teeth (1,000-ppm fluoridated dentifrice), as well as advices regarding diet and information about dental caries was given by a dental assistant and those instructions were repeated every 6 months.
PROBLEM TO BE SOLVED: To obtain the above adjuvant, comprising an aqueous solution of hyaluronic acid, having a medium viscosity containing a specific viscosity stabilizer, excellent in long term-storage stability at ambient temperature and capable of preventing viscosity-lowering even under an ordinary condition of heat pasteurization. SOLUTION: This adjuvant includes (A) hyaluronic acid and/or the solt and (B) a polycarbonic acid or the soil (preferably sodium citrate, carboxyvinyl polymer), a polyol (preferably ethylene glycol, glycerin, etc.), a saccharide (preferably solbitol, trehalose, etc.) and a viscosity stabilizer selecting from an amino acid and the solt (preferably histidine, arginine etc.) and consists of an aqueous solution having a viscosity of 2000-20,000 centipoise at 37 deg.C. Sodium sat is preferable as the hyaluronic acid salt. Moreover, a blending amount of the component B is preferable to be each 0.05-1(weight)% in the case that the component B is a polycarbonic acid and the salt or an amino acid, 1-2.5% in case of the polyol and 0.05-5% in the case of the saccharide.
This study investigates the effectiveness and cost-effectiveness of the concurrent use of a CDSS and a patient portal for personalized FRID deprescribing, and will be assessed through a multicenter cluster-randomized controlled trial among new fall clinic patients, aged 65 years or older. The main study parameter is the time to first injurious fall. The primary objective of the ADFICE_IT study is to investigate the effects of a CDSS and accompanying patient portal for optimizing FRID deprescribing on injurious falls. This study has three secondary objectives. First, the effect of the CDSS and patient portal on a number of secondary outcomes will be investigated. Second, a process evaluation to evaluate the implementation of the CDSS and patient portal will be conducted. Third, the cost-effectiveness of the CDSS and patient portal will be investigated.
The present invention is a novel thermally-responsive record material comprising a substrate having provided thereon in substantially contiguous relationship an electron donating dye precursor, an acidic developer materia l, a compound of formula (I) wherein P is selected from (II) and (III), wherein  R~1?, R~2? and R~3? are independently selected from hydrogen, alkyl, alkoxy,  aryl, aralkyl, aralkoxy, halogen, and alkoxyalkoxy; wherein R~4? is independently selected from alkoxyalkyl, alkoxyalkoxy, and aralkoxyalkoxy, a nd a suitable binder therefor. In the context of the present invention the alky l moieties in the alkyl, aralkyl, aralkoxy, alkoxyalkyl, alkoxyalkoxy and aralkoxyalkoxy preferably are eight carbons or less, and more preferably fro m one through four carbons. Substituents on aryl moieties in aryl, aralkyl, aralkoxy, and aralkoxyalkoxy groups can include hydrogen, alkyl, alkoxy and halogen. The alkyl group in these substituents also is eight carbons or less , and more preferably from one through four carbons. The thermally responsive record material of the invention has the unexpected and remarkable propertie s of enhanced image intensity or density, and/or improved thermal response.</S DOAB>
All Kidney and Liver Transplant recipients who are at follow-up in our institution will be enrolled. anti-COVID-19 title was obtained by ECLIA Test(Elyx, Roche). In the case of antibody level \<100 IU/ml, patients were invited to prophylaxis with tixagevimab-cilgavimab(AZD7442, AstraZeneca). At three months, a follow-up was performed to assess any COVID-19 infection.
Family caregivers of frail older adults with cognitive impairments face special challenges in caring for their care recipients (CR) due to their fast declining health. Examples of difficulties include managing CR's behaviors and daily activities, as well as maintaining their own psychological and physical health, which result in high caregiver burden. The aim is to support these caregivers of older adults who are enrollees of the Program for All-inclusive Care for the Elderly (PACE) through occupational therapy (OT) interventions to reduce caregiver burden and depression, and increase positive aspects of caregiving and self-efficacy. Since PACE organizations offer limited support for caregivers due to understanding, supervised OT graduate students (OTGS) will provide caregivers with customized supports. By doing so, the students will gain precious experience before they enter the workforce. This proposal will develop and test the effectiveness of this collaborative model. This study will use a randomized controlled design with about a 4- month intervention period. The assessments will take place at baseline, 2 months and 4 months. The study period will be two years. Participants will be 60 convenience family caregivers of the PACE enrollees in Western New York; therefore, CRs are 55 years old or older, need a nursing home level of care, but remain living in the community. Caregivers are adults who visit the CR at least once a week. OTGS will contact the caregivers, using a phone, and conduct an in depth interview to understand their difficulties. Then solutions will be brainstormed amongst OTs and geriatric specialists, and interventions will be formed. At the first visit to the CRs' homes, interviews will be conducted using the Zarit Burden Interview, the Center for Epidemiology Study for Depression, the Buffalo Fatigue Scale, the Positive Aspect of Caregiving, and the Visual Analogue Scale for self-efficacy. The possible solutions will be discussed with caregivers and more detailed difficulties will be videotaped. The solutions that caregivers are comfortable with will be reviewed by the PACE Rehabilitation Department and need to be approved before their implementation. The solutions may include: education of disease process, training for caregivers in supporting CR's activities of daily living (ADL) and instrumental ADL, coordination of family caregivers, problematic behaviors, functional exercise, fall prevention, and increased number of CR's visits to a PACE daycare facility. Statistical analysis will use Generalized Estimating Equations to compare the two groups' linear trends. We expect CRs' condition will deteriorate but the treatment group will reduce caregiver burden and increase self-efficacy.
Inappropriate intake of whole milk, fruit juice, and sugar-sweetened beverages is associated with childhood obesity, obesity-related co morbidities, and dental caries, yet there are few proven interventions to promote child intake of healthy beverages consistent with national guidelines. Child care facilities provide a potential venue for influencing healthy beverage intake in children and families. The overall objective of this study is to use principles of community-based participatory research (CBPR; an approach in which researchers partner with community members to conduct research) to develop, pilot test, and examine the acceptability, feasibility, sustainability, and preliminary outcomes of a child care-based intervention to encourage child intake of age-appropriate, guideline-recommended beverages. The central hypothesis is that a multi-level intervention consisting of educational strategies to encourage intake of guideline-recommended beverages; increased accessibility of lead-free, fluoridated, drinking water in child care and at home; and evidence-based child care and home beverage policies will lead to healthier beverage intake and reduced childhood obesity. This hypothesis was tested through a quasi-experimental trial in four child care centers. Centers were randomized to a control (delayed-intervention) condition or to receive a 12-week intervention that promoted consumption of healthy beverages (water, unsweetened low-fat milk) and discouraged consumption of unhealthy beverages (juice, sugar-sweetened beverages, high-fat or sweetened milk). The multi-pronged intervention was delivered via child care centers, targeted children, parents, and child care staff, and included education, environmental changes, and policies. Outcomes were measured at baseline and immediately post-intervention and included children's (n =154) at-home beverage consumption (assessed via parental report) and overweight/obese weight status (assessed via objectively measured height and weight).
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to erythropoietin liposomal dispersion. Liposome-base composition contains: (a) effective amount of erythropoietin; (b) lipid phase comprising: (i) lecithin or hydrogenated lecithin; (ii) optionally charged electropositive or electronegative lipid compound; and (iii) cholesterol or its derivative taken among cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols) and organic acid derivatives of cholesterols; and (c) phosphate buffer. Invention provides preparing the liposome-base composition for parenteral administration that excludes using human serum albumin and composition shows the excellent stability. EFFECT: valuable medicinal and pharmaceutical properties of dispersion. 14 cl, 2 tbl
Stage 2 (Phase III Study) For a 1:1 ratio of patients treated with EB05 vs. Placebo, a cumulative one-sided alpha of 2.5% and 90% power, to detect an Odds Ratio of 2.00, a total of 586 evaluable patients will be required for Stage 2 (Phase III study). 293 of these will be treated with EB05 + SOC and 293 treated with Placebo + SOC. Allowing for 10% attrition, a total of 644 patients will be enrolled in this Stage.
INTRODUCTION: Obesity is a chronic noncommunicable disease, defined by a body mass index over 30 kg/m2. Its impact is not restricted to its association with higher risks of mortality and morbidity from other noncommunicable diseases, but also with a decrease in quality of life (QoL). There are several tools to assess QoL, from generic health-related tools to obesity-related specific ones. However, to assess QoL in patients undergoing bariatric surgery, only the Bariatric Analysis and Reporting Outcome System was available, which presented some significant problems. Therefore, the Bariatric Quality of Life (BQL) Index was developed. The aim of this study was the validation and cultural adaptation of the BQL Index for European Portuguese.
METHODS: A cross-sectional study was conducted, with the presentation of two questionnaires to the participants: BQL Index and EQ-5D-3L (European Quality of Life 5 Dimensions and 3 Level) Index. Direct translation followed reviewing, back-translation, comparison, and pilot testing were performed. Retest was done six months after the baseline. The following psychometric properties were assessed: convergent validity using the Spearman r correlation coefficient between BQL Index and EQ-5D-3L Index; internal consistency based on Cronbach alpha coefficient; and reproducibility between test and retest through Spearman r correlation coefficient and intraclass correlation coefficient (ICC).
RESULTS: A total of 260 participants were included, the mean age was 45 ± 10 years old, the mean body mass index was 44 ± 6.5 kg/m2 and 78% were females. The most frequent obesity-related comorbidities were osteoarticular disease (69%), anxiety/depression (60%), and hypertension (54%). The most common eating patterns were volume eater (67%) and sweet eater (62%). Quality of Life scores were 41.3 ± 9.3 for the BQL Index, 0.35 ± 0.19 for the EQ-5D-3L Index and 55.7 ± 19.8 for the EQ-5D-3L VAS. The translation yielded good convergent validity (r = 0.62), good internal consistency (alpha = 0.94), and good reproducibility (r = 0.62 and ICC = 0.79).
CONCLUSION: Our translation exhibited good parametric properties, with validity within the original BQL values, higher internal consistency, and good reproducibility.
In normal heart, there are two working lower chambers where one chamber pumps the blood to the lungs and other chamber pumps the blood to the body. However, some congenital heart conditions have only one working lower chamber of the heart called the 'Single Ventricle'. This condition is often associated with hole between the heart chambers with increased or decreased blood flow to the lungs. This can lead to mixing of blood in the heart with low oxygen levels in the body. The surgery for single ventricle is usually performed in stages starting from the infancy. Fontan surgery is the last stage where the two big veins that return the blood to the heart is connected to the lung artery directly. This surgery improves the oxygen levels in the blood and lessens the burden on the single ventricle. The blood is not pumped to the lungs by the heart but rather enters passively to the lungs through this new surgical connection. Some people operated for Fontan surgery have many short-term and long-term complications such as increased pressure in veins , poor heart function and low oxygen levels in the blood. In particular, the organs below the chest such as kidney, liver and gut are affected, and all of these predict poor outcomes. The reason for these complications are poorly understood.

The small blood vessels in the body or 'microcirculation' are very tiny and are less than 150 microns in diameter. These includes arterioles, capillaries, and venules. Very little is known about the microcirculation in adult Fontan survivors and its association with aortic stiffness, late complications, and quality of life. In this study, The investigators want to look at the blood vessels in adult Fontan survivors, people operated for other congenital heart diseases, and healthy volunteers using a special microscope called Hand Held Capillary Microscopy. The investigators will visualize their blood vessel appearance, number, and size they have in their hands, feet, and under the tongue. This procedure is non-invasive and will not cause any pain. The aortic stiffness will be measured non-invasively using a special blood pressure monitor called Mobile 'O' Graph, which is about size of a pocket diary. 24 hour blood pressure monitoring is optional. The investigator will also collect the information about the quality of life using questionnaires as few studies have shown that the quality of life is affected in adult Fontan survivors and it was associated with poor vascular function. Age matched healthy controls and adults survivors of other congenital heart surgeries will also undergo these tests for comparison purpose. This study will be conducted at East Midlands Congenital Heart Centre, Glenfield Hospital, Leicester.
Systems and methods of creating, managing and accessing treatment plans for patients having a condition are disclosed herein. Patients have CarePods created for the treatment of their condition and their doctors and other caregiver relevant to their treatment. In one embodiment, treatment plans may be constructed by a plurality of modules that may input data and metadata regarding the condition, the treatment, potential medications, potential medical monitoring equipment. Such treatment plans may be employed as a template for other CarePods and other patients. In other embodiments, data from the treatment may be collected to inform caregivers the response of the patient to treatment. In addition, data from the treatment of a condition may be aggregated from a plurality of patients being treated for a condition. This aggregated data may be used to deduce the efficacy of a particular treatment to a condition.
An artificial intelligence/machine learning based bioinformatics platform for encephalopathy and a medical decision improvement method are provided. The artificial intelligence/machine learning based bioinformatics platform includes an evidence-based clinical system and an evidence-based education system. The evidence-based clinical system includes a clinical research device and a collaborative workstation. The clinical research device is capable of collecting and analyzing basic information of a patient to generate effective medical information. The collaborative workstation is configured to obtain medical interaction information between a physician and the patient and translate a pragmatic clinical trial according to the medical interaction information and the effective medical information. The evidence-based education system can obtain legal medical means information, and establish real-world evidence according to the legal medical means information, the effective medical information, and the medical interaction information, so as to selectively modify the effective medical information and the pragmatic clinical trial.
The participants in the sage oil massage group (30 participants in total) had pain in the first 3 days of their menstrual cycle; when the pain started, pain levels were scored by the participants using visual analog scale (VAS). In addition, their blood pressure, body temperature, and pulse rate were measured. The researchers massaged the abdomen with sage oil for 30 minutes, and 30 minutes after the massage, VAS evaluation and blood pressure, body temperature, and pulse rate measurements were performed again. This application was repeated for two menstrual periods.
Portal hypertension is a common complication of chronic liver disease and is associated with most clinical consequences of cirrhosis. The most reliable method for assessing portal hypertension is the measurement of the hepatic venous pressure gradient (HVPG). The HVPG is the gold-standard methods for assessing clinically significant portal hypertension and becoming increasingly used clinically. It is useful in the differential diagnosis of portal hypertension and provides a prognostic index in cirrhotic patients. Many patients are painful and reluctant to undergo serial HVPG measurements. But interventionists are reluctant to use analgesics because they always pay more attention to the accuracy of HVPG measurements. May be since it is difficult to monitor HVPG for anesthesiologist during liver surgery, there are very few and controversial studies on the effects of sedation and analgesics on HVPG. M. Susan Mandell et al concluded that desflurane alters HVPG measurements, whereas propofol did not change it (Anesth Analg 2003). However, Enric Reverter et al considered that deep sedation with propofol and remifentanil adds substantial variability and uncertainty to HVPG measurements (Liver International 2013). Although Adam F. et al concluded that low-dose midazolam sedation is an option for patients undergoing serial hepatic venous pressure measurements (Hepatology 1999), the effects of using opioid analgesics alone on hepatic venous pressure measurements have not yet been defined. The objective of this study was to evaluate the effects of fentanyl on the HVPG measurements.