anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nebivolol is a β-adrenergic receptor blocking agent. In extensive metabolizers (most of the population) and at doses less than or equal to 10 mg, nebivolol is preferentially β1 selective. In poor metabolizers and at higher doses, nebivolol inhibits both β1 and β2 \- adrenergic receptors. Nebivolol lacks intrinsic sympathomimetic and membrane stabilizing activity at therapeutically relevant concentrations. At clinically relevant doses, nebivolol does not demonstrate α1-adrenergic receptor blockade activity. Various metabolites, including glucuronides, contribute to β-blocking activity.
Patients diagnosed with a TAA of degenerative etiology that are considered candidates for open surgical repair whom are low to moderate risk (0, 1, \& 2) per the modified SVS/AAVS criteria who meet inclusion/exclusion criteria. The aneurysm must be at least 20 mm distal to the left common carotid artery \& 20 mm proximal to the origin of the celiac artery.
Transcatheter arterial chemoembolization is currently the mainstays of palliative treatments worldwide for patients with unresectable HCC. However there is no standard protocol exists for TACE currently. One of the controversy is does the way of emulsified the anticancer agents and lipiodol to get a high stability suspension really effect the survival rates.

Anticancer drugs play important role in survival benefit. Many studies have innovated different methods to get a high stability suspension of lipiodol and anticancer drugs ,because they think lipiodol can selectively retained in HCC and used as a drug-carrying which allow a slow release of the anticancer drug from lipiodol microdroplets. Thus ,A stability suspension might get a maximize tumor drug uptake,which can caused a more tumor necrosis, and minimize systemic drug levels ,which get a less toxicity, hence survival benefit. While the other researcher think a stability emulsion can't get a positive effect ,such as pharmacokinetic and systematic toxicity of the anticancer drugs, tumor response, biologic response and so on.
All of the patients receive conventional concurrent radiochemotherapy with capecitabine for 5 weeks. Then all of the patients receive 2 cycles/6 weeks capecitabine ± Oxaliplatin chemotherapy. Patients receive rectectomy including anterior resection or abdominoperineal resection by open or laparoscopy with total mesorectal excision 8 weeks post radiotherapy. All of the patients receive 5 cycles/15 weeks capecitabine ± Oxaliplatin adjuvant chemotherapy. The use of Oxaliplatin depends on the doctor's decision.
A multi-centered bronchiectasis patient registry would be founded, which will include patients from three teaching hospital (Ruijin Hospital, Zhongshan Hospital and Shanghai Pulmonary Hospital) in Shanghai at the beginning. The network will be promoted to other cities and different places in China. Patients with bronchiectasis would be enrolled and detailed information would be recorded. Follow-up of patients would provide more information on the prognosis of disease. Optimal treatment studies for the patients will be initiated one by one based on the network. The investigators are committed to promoting clinical research and education in bronchiectasis, through sharing of protocols, research idea and expertise.
Taper and Monitoring (TAP-M) is delivered in biweekly individual sessions over 14 weeks, with booster sessions at two, four, and eight weeks thereafter. TAP-M consists of assessment and monitoring. Participants will also receive 7 biweekly medication management sessions over 14 weeks with a study psychiatrist to facilitate gradual taper of SRI medication.
Background: Recent studies have demonstrated that activated microglia were involved in the pathogenesis of central sensitization characterized by cutaneous allodynia in migraine. Activation of microglia is accompanied by increased expression of its receptors and release of inflammatory mediators. Acupuncture and its developed electroacupuncture (EA) have been recommended as an alternative therapy for migraine and are widely used for relieving migraine-associated pain. However, it remains rare studies that show whether EA exerts anti-migraine effects via inhibiting microglial activation related to a release of microglial receptors and the inflammatory pathway. Therefore, this study aimed to investigate EA' ability to ameliorate central sensitization via modulation of microglial activation, microglial receptor, and inflammatory response using a rat model of migraine induced by repeated epidural chemical stimulation. Methods: In the present study, a rat model of migraine was established by epidural repeated inflammatory soup (IS) stimulation and treated with EA at Fengchi (GB20) and Yanglingquan (GB34) and acupuncture at sham-acupoints. Pain hypersensitivity was further determined by measuring the mechanical withdrawal threshold using the von-Frey filament. The changes in c-Fos and ionized calcium binding adaptor molecule 1 (Ibal-1) labeled microglia in the trigeminal nucleus caudalis (TNC) were examined by immunflurescence to assess the central sensitization and whether accompanied with microglia activation. In addition, the expression of Ibal-1, microglial purinoceptor P2X4, and its associated inflammatory signaling pathway mediators, including interleukin (IL)-1β, NOD-like receptor protein 3 (NLRP3), and Caspase-1 in the TNC were investigated by western blot and real-time polymerase chain reaction analysis. Results: Allodynia increased of c-Fos, and activated microglia were observed after repeated IS stimulation. EA alleviated the decrease in mechanical withdrawal thresholds, reduced the activation of c-Fos and microglia labeled with Ibal-1, downregulated the level of microglial purinoceptor P2X4, and limited the inflammatory response (NLRP3/Caspase-1/IL-1β signaling pathway) in the TNC of migraine rat model. Conclusions: Our results indicate that the anti-hyperalgesia effects of EA ameliorate central sensitization in IS-induced migraine by regulating microglial activation related to P2X4R and NLRP3/IL-1β inflammatory pathway.
The number of treatment sessions will consist of a total of 6 sessions, so there will be two sessions over 3 weeks. The evaluations of the participants will be carried out before and after the first session, after the last session of the treatment program received, 15 days and one month after finishing the treatment.
Oral contraceptives are indicated for the prevention of pregnancy in women who elect to use Myzilra® Tablets as a method of contraception. Oral contraceptives are highly effective. TABLE I lists the typical accidental pregnancy rates for users of combination oral contraceptives and other methods of contraception. The efficacy of these contraceptive methods, except sterilization and the IUD, depends upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates. 

Adapted from Hatcher RA et al, Contraceptive Technology: 17th Revised Edition. NY, NY: Ardent Media, Inc., 1998.
This group will be the randomized selected patients who will not get any intervention. Patients will fill the Amsterdam Preoperative Anxiety and Information Score Scale preoperatively at the hospital. After the surgery, the patients will be evaluated by the researchers in terms of pain scores and analgesic usage frequency in the recovery room and 1st, 4th, 8th, 12th, 24th, 36th and 48th hours data will be collected in the postoperative service.
Implantation cyst is often reported to be a delayed complication after colorectal surgery. This report presents a 70-year-old man undergoing gastrectomy 33 years earlier for an acute gastric ulcer. His endoscopic finding showed a submucosal tumor about 20 mm in diameter at the gastro-jejunal anastomosis. Endoscopic ultrasonography showed that the tumor was a cystic mass that was continuous from the third layer, but there were no existences of internal substantial nodules, indicating that the tumor was diagnosed as implantation cyst. This is the first report showing that implantation cyst can occur at gastro-jejunal anastomosis. We should take into account the occurrence of implantation cyst, when we encounter a submucosal tumor at gastro-jejunal anastomosis after surgery even if a long period has passed.
FIELD: biology, pharmacology, veterinary science. SUBSTANCE: invention proposes the complex preparation that has avermectin complex as avermectin N from Streptomyces avermitilis VKPM S-1440 mycelium as an antiparasitic agent with increased content of component of the group B (67.8-77.4%). Also, other avermectin complexes (aversectin C, ivermectin or other aver-mectin-base active substances) can be used as drugs. Ribotane is used as an immunostimulating and antiinflammatory agent that enhances body-host resistance and prevents topical response. Ethyl alcohol and benzyl alcohol are used as solvent. Polyvinyl-pyrrolidone and polyethylene glycol-400 are used as disintoxicating, chelating agent that prolongs curative effect of the preparation. Also, distilled water is used and all components are taken in the definite ratio. Preparation is administrated by subcutaneous route and after one-two dose it provides 100% curative antiparasitic effectiveness being without suppression of immune system and topical response in animals. Invention can be used for prophylaxis and treatment of animals with diseases caused by mites, insects, nematodes of different species. EFFECT: enhanced effectiveness of preparation. 3 cl, 1 tbl, 7 ex
The invention relates to an agomelatine inclusion compound and a preparation method and application thereof. The agomelatine inclusion compound comprises agomelatine and cyclodextrin or derivatives of cyclodextrin. The agomelatine inclusion compound is characterized in that the agomelatine inclusion compound does not have a melting point endothermic peak of agomelatine. According to the preparation method, the agomelatine is included or embedded into the cyclodextrin or derivatives of cyclodextrin through inclusion, thus forming the agomelatine inclusion compound. The agomelatine inclusion compound is in a novel agomelatine solid form, and the polymorphism or mixed crystal problem of the agomelatine can be effectively solved, so that the production process is simplified. Meanwhile, the inclusion compound has the advantages of high water solubility and high stability, and the preparation method is easy and convenient to operate, low in material consumption and low in cost. The invention also discloses application of the agomelatine inclusion compound in preparation of pharmaceutical preparations for treating depression. Therefore, the agomelatine inclusion compound has extremely practical value in development and application of agomelatine.
Cook Catheter is placed and a placebo tablet is given orally. A repeat dose is administered in 3 hours.
Dorso-radial incision, capsulotomy between extensor pollicis brevis (EPB) and APL protecting the radial artery. A second incision is made on dorsum of hand between the 2nd and 3rd MCs. A cannulated drill with suture passer is passed from base of 1st MC to mid 2nd MC. The TightropeTM is passed from 1st to second MC with one button on the base of the 1st MC. Trapeziectomy is then performed using a cruciate osteotomy and rongeurs. The thumb is adducted against index MC to avoid excessive tightening and the suture is tied over a second button on the 2nd MC. Closure of capsule with Vicryl. Closure of skin with running Prolene suture.
Knee osteoarthritis (OA) is a prevalent disorder with significant global health implications, its prevalence varying across populations due to intricate factors. Recent investigations highlight an age-related increase in knee OA prevalence, particularly impacting those aged 60 and above, with projections indicating heightened impact due to aging demographics. Recent pathogenesis studies illuminate the intricate molecular and cellular processes underlying knee osteoarthritis (OA), encompassing cartilage degradation, subchondral bone changes, and inflammation.Recent advancements have expanded knee osteoarthritis (OA) management, including medical, surgical, and physiotherapy interventions. Pharmacological treatments such as analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), and disease-modifying osteoarthritis drugs (DMOADs) remain fundamental for pain alleviation and inflammation reduction. Intra-articular therapies like corticosteroid injections and hyaluronic acid supplements offer localized relief and potential disease-modifying effects.Surgical interventions like total knee arthroplasty (TKA) provide pain relief and improved function for end-stage OA. Minimally invasive techniques like partial knee replacements and patient-specific implants aim to preserve joint function and enhance outcomes. Physiotherapy and rehabilitation are crucial, in improving stability, muscle strength, and mobility. Studies highlight tailored exercises, neuromuscular training, and proprioceptive exercises in managing OA symptoms. The integration of these approaches underscores comprehensive knee OA management, addressing pain, function, and quality of life. The outcomes of this study could offer evidence-based recommendations for clinicians, aiding them in selecting the most appropriate manual therapy approach to alleviate pain, enhance joint mobility, and improve functional capacity in knee OA patients. Ultimately, this research seeks to contribute to the optimization of knee OA management strategies, improving the well-being of those affected.
Subjects with CKD will undergo progressive whole body stretching and toning exercises 3 times a week for 20-45 minutes for 6-12 weeks. Additionally, subjects will take 1300-2600 mg (2-4 pills) of sodium bicarbonate prior to each stretching session three times a week.
FIELD: cosmetic industry.SUBSTANCE: group of inventions relates to the cosmetic industry, specifically to a composition for dyeing keratin fibres, comprising: (a.) tris(hydroxymethyl)aminomethane; (b.) at least one amino acid selected from arginine, glycine, lysine, alanine, glutamine, histidine and serine; (c.) a mixture (c1.) of phosphoric acid monoester and alkoxylated Cfatty alcohols and (c2.) a diester of phosphoric acid and non-alkoxylated Cfatty alcohol; (d.) water, wherein the composition does not contain ammonia, ammonium salts or a peroxymonocarbonate ion source. Invention also discloses: a method of producing a dispersion containing said composition; kit for dyeing keratin fibres containing the composition in separately packed form and a developer composition containing an oxidant; ready-to-use composition obtained by mixing components of said kit; method of dying keratin fibres.EFFECT: group of inventions provides improved properties of applying on keratin fibres, distribution and flushing therewith, as well as reduced hair damage during treatment.20 cl, 4 dwg, 6 tbl, 10 ex
Hyperventilation-induced nystagmus test (HINT) is capable of generating a response in 77.2% of cases of acute unilateral vestibulopathy (AUVP); both nystagmus toward the affected side (excitatory pattern) and toward the healthy side (inhibitory pattern) have been described. The aim of the study is to investigate the clinical and prognostic role of the test by evaluating its correlation with vestibulo-ocular reflex (VOR) gain. We evaluated 33 AUVP patients by performing the HINT and video head impulse test (V-HIT) during the acute phase and then at 15 and 90 days after the onset of the symptoms. The correlation between the VOR gain of the affected side and test responses was evaluated first, phase by phase, and then considering the pattern shown during the first assessments. Patients with a negative HINT had a higher mean VOR gain than patients with a positive test at both 15 and 90 days. Patients who showed an inhibitory pattern at the first assessment had a continuous improvement in V-HIT performance, while patients with an initial excitatory response had a transient decrease in gain at the subsequent evaluation (P=.001). No difference between these 2 groups emerged at 90 days (P=.09). The finding of a negative HINT during the follow-up correlates with good V-HIT performance and could be an indicator of good recovery. The inhibitory pattern is associated with a subsequent improvement; and it would be indicative of compensation. but, despite this, the prognostic value of the test is limited.
This study intends to use a retrospective study design method to continuously collect immune cell and inflammatory factor data of 5ml peripheral blood and 10ml joint fluid from 200 patients who met the inclusion and exclusion criteria in our department starting from January 2021. The aim is to analyze the impact of changes in inflammatory factors before and after surgery on postoperative recovery. The indicators of postoperative rehabilitation for patients were objectively evaluated using three scales: Lysholm scale, VAS scale, and Tegner scale. Among them, the Lysholm scale mainly evaluates the postoperative recovery of knee joint function in patients, with values ranging from 0 to 100. The higher the value, the better the recovery; The VAS scale mainly evaluates the postoperative pain score of patients, with values ranging from 0 to 10. The higher the value, the more severe the pain; The Tegner scale is also mainly used to evaluate the postoperative recovery of knee joint function in patients, with values ranging from 0 to 10. The higher the value, the better the recovery.
This is a multi-center randomized clinical trial comparing laparotomy vs peritoneal drainage for perforated Necrotizing Enterocolitis. The current literature does not allow an objective comparison between these two methods. A recent comprehensive meta-analysis of all published and much unpublished data regarding the use of these procedures in the treatment of perforated NEC revealed that the degree of bias in assignment to treatment precluded an adequate determination as to the best treatment. The conclusion that only a randomized clinical trial would answer this question has led to this multi-center effort. The relative infrequency of the disease at any one neonatal center has necessitated enrollment of patients at many centers.

Comparison: Premature neonates weighing less than 1500 grams at birth who develop perforated necrotizing enterocolitis are randomized within two birth weight blocks (\<1000 gms and 1000 - 1499 gms) for treatment with either laparotomy or primary peritoneal drainage. Daily postoperative clinical care is kept uniform between the two groups by means of a critical care pathway. The primary outcome variable is mortality, i.e. death within 90 days of intervention. The main secondary outcome is short bowel syndrome - defined as the need for chronic parenteral nutrition greater than 3 months following operation.
Described here are methods and devices for treating an eye, where an epithelial flap has been raised from the eye by epithelial delamination. Some of the treatment methods comprise administering an effective treatment agent to a cornea, epithelium, or eye, before, during, or after the delamination. A number of treatment agents are described. Exemplary treatment agents include adhesion molecules, lubricants, nourishing agents, growth factors, and the like. Other described treatment methods and the devices for such treatment involve cooling the eye, epithelium, or cornea, before, during, or after the delamination. In some variations, the step of cooling comprises cooling a delaminating device to an effective temperature during the delamination. In other variations, the step of cooling comprises introducing a cool fluid to the eye, epithelium, or cornea, before, during, or after the delamination. Other described methods involve the modification of a bandage contact lens, and the introduction of intact epithelial cells to the epithelial flap.
The present invention is based on a newly discovered function of RBCs. It is discovered that RBCs contain antigens which are different from their proteome. Those antigens can be precipitated/separated using plasma of blood from which RBCs were taken. It is found that those antigens consist of HLA antigens, tissue specific antigens, and foreign antigens. The foreign antigens can be fetus antigens in pregnant females, tumor antigens, microorganisms antigens, food, insects or other antigens from environment. The collection of those transported antigens represent a dynamic store. Consequently, RBCs may play role in tolerance through transporting those antigens to central organs of the immune system. The idea, in the presented invention, is to exploit this store in producing a number of products. Those products include vaccines, clinical laboratory kits and treatment components. The vaccine products cover: vaccines for bacteria, viruses and parasites in humans and animals; and vaccines for the prevention of malignant tumors in patients showing malignant transformation or as a supportive treatment of patients already having a tumor. The clinical laboratory kits covers: diagnostic kits for efficient diagnosis of diseases caused by microorganisms in humans and animals; diagnostic kits for malignant tumors; tissue typing kits for organ transplantation; and monitoring kits for organ rejection and hypersensitivity. The treatment components will help in treatment of difficult disorders including, among others, hypersensitivity disorders, chronic graft rejection, and autoimmune disorders. In effect, the products that can be produced based on this discovery are innumerable. The invention methods are based on selecting specific disease transported antigens, identify those antigens, manufacture those antigens, and then produce an appropriate product.
The invention discloses a formula of a traditional Chinese medicine for treating hyperlipidemia. The unit dosage of the traditional Chinese medicine comprises 15g of haws, 15g of ginkgo leaves and 15g of fiveleaf gynostemma herb. The above medical raw materials are weighed according to the above weight ratio and are mixed with water. The soup is taken as a tea. A treatment course comprises half month and after four treatment courses, hyperlipidemia can be cured. The traditional Chinese medicine solves the problem that the conventional treatment drug has a high recurrence rate and large side effect, has a long use period, causes addiction, has a high recurrence rate after drug discontinuance and cannot thoroughly cure diseases. The traditional Chinese medicine is suitable for treatment on hyperlipidemia.
BACKGROUND: Former American football players are at risk for chronic traumatic encephalopathy (CTE) which may have parkinsonism as a clinical feature.
OBJECTIVE: Former football players were prospectively assessed for parkinsonism.
METHODS: 120 former professional football players, 58 former college football players, and 60 same-age asymptomatic men without repetitive head impacts, 45-74 years, were studied using the MDS-UPDRS to assess for parkinsonism, and the Timed Up and Go (TUG). Traumatic encephalopathy syndrome (TES), the clinical syndrome of CTE, was adjudicated and includes parkinsonism diagnosis. Fisher's Exact Test compared groups on parkinsonism due to small cell sizes; analysis of covariance or linear regressions controlling for age and body mass index were used otherwise.
RESULTS: Twenty-two (12.4%) football players (13.3% professional, 10.3% college) met parkinsonism criteria compared with two (3.3%) in the unexposed group. Parkinsonism was higher in professional (p = 0.037) but not college players (p = 0.16). There were no differences on the MDS-UPDRS Part III total scores. Scores on the individual MDS-UPDRS items were low. TUG times were longer in former professional but not college players compared with unexposed men (13.09 versus 11.35 s, p < 0.01). There were no associations between years of football, age of first exposure, position or level of play on motor outcomes. TES status was not associated with motor outcomes.
CONCLUSIONS: Parkinsonism rates in this sample of football players was low and highest in the professional football players. The association between football and parkinsonism is inconclusive and depends on factors related to sample selection, comparison groups, and exposure characteristics.