anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicine suppository for treating ulcerative colitis. The traditional Chinese medicine suppository is prepared from the following raw material medicines in parts by weight: 9-19 parts of rhizoma bletillae, 6-14 parts of dragon's blood, 10-20 parts of cutch, 14-26 parts of hairyvein agrimony, 10-20 parts of cuttlebone, 10-20 parts of red halloysite, 6-14 parts of garden burnet and 15-31 parts of radix angelicae. The traditional Chinese medicine suppository disclosed by the invention is unique in composition, strict in formula and refined in selected medicines, a synergistic effect is achieved among various medicines, and the medicines supplement each other. According to local drug delivery, the local medicine concentration is increased, the medicine can directly reach lesions, volatilization of some pharmaceutical active ingredients is avoided, wound healing is promoted, and the curative effect is exact. Therefore, the ulcerative colitis is rapidly repaired, the reoccurrence rate of ulcer is reduced, and the incidence rate of rectal cancer is reduced. The clinical observation proves that the total effective rate is 98 percent. The traditional Chinese medicine suppository has the characteristics of rich raw material source, simple preparation method, low cost, fast effectiveness, short course of treatment, high effective rate, no reoccurrence after drug withdrawal, no toxicity, safety and reliability.
Participants with problematic smartphone use were identified with the Smartphone Addiction Scale Short Form. Participants with a score below 31 for women and 33 for men were defined as the control group.
Detailed Description: This study is being done to demonstrate the feasibility, acceptability and effectiveness of a telehealth Group Behavioral Activation Therapy (GBAT) for autistic adults. GBAT is intended to help adults manage stress, anxiety, down moods, and anger. Similar programs have been shown to be effective in other contexts but has not yet been used for autistic adults or delivered via telehealth. Because this is a new intervention, the investigators are interested in learning 1) whether GBAT can be done with autistic adults (feasibility), 2) what autistic adults think about GBAT (acceptability), and 3) whether GBAT is effective for helping autistic adults cope with their feelings. Results from this study will be used to inform adaptation to the intervention and planning for future studies to further explore its effectiveness. For this initial feasibility study, 8 autistic adults (18-40 years old) with VIQ and NVIQ\>85, reading composite at least 6th grade level and elevated symptoms of depression, anxiety or anger will be recruited.
The invention discloses enzyme facial mask essence with moisturizing and whitening functions. The facial mask essence is composed of the following components in parts by weight: 4-6 parts of enzyme stoste, 4-6 parts of seamollient, 4-6 parts of mucopolysaccharide, 3-5 parts of glycerinum, 3-4 parts of emulsifying agent, 2-4 parts of arbutin, 2-4 parts of shiitake mushroom dextran, 3-4 parts of hyaluronic acid, 1-3 parts of collagen peptide powder, 0-2 parts of natural vitamin E, 4-6 parts of propylene glycol, 0-1.5 parts of thickening agent, 0.4-0.8 part of dipotassium glycyrrhizinate, 0.1-0.3 part of preservative, 0.05 part of essence and 50-70 parts of deionized water. The invention further discloses a preparation method of the enzyme stoste. The preparation method comprises the following steps: (1) fruit pre-treating; (2) fermenting; and (3) filling. The enzyme facial mask essence disclosed by the invention is scientific in formula, reasonable in process, comprehensive in functions, free of harmful chemicals, capable of effectively removing stain, melanin, cuticle and the like and capable of playing remarkable moisturizing and whitening functions. Such materials as silk, non-woven fabrics and poly fruit acid and the like are soaked in the essence disclosed by the invention and can be prepared into facial mask finished products with moisturizing and whitening functions after being packaged by aluminum foil bags.
It is generally accepted that oxidative stress plays a key role in the development of ischemia-reperfusion injury in ischemic heart disease. However, the mechanisms how reactive oxygen species trigger cellular damage are not fully understood. Our study investigates redox state and highly reactive substances within neonatal and adult cardiomyocytes under hypoxia conditions. We have found that hypoxia induced an increase in H2O2 production in adult cardiomyocytes, while neonatal cardiomyocytes experienced a decrease in H2O2 levels. This finding correlates with our observation of the difference between the electron transport chain (ETC) properties and mitochondria amount in adult and neonatal cells. We demonstrated that in adult cardiomyocytes hypoxia caused the significant increase in the ETC loading with electrons compared to normoxia. On the contrary, in neonatal cardiomyocytes ETC loading with electrons was similar under both normoxic and hypoxic conditions that could be due to ETC non-functional state and the absence of the electrons transfer to O2 under normoxia. In addition to the variations in H2O2 production, we also noted consistent pH dynamics under hypoxic conditions. Notably, the pH levels exhibited a similar decrease in both cell types, thus, acidosis is a more universal cellular response to hypoxia. We also demonstrated that the amount of mitochondria and the levels of cardiac isoforms of troponin I, troponin T, myoglobin and GAPDH were significantly higher in adult cardiomyocytes compared to neonatal ones. Remarkably, we found out that under hypoxia, the levels of cardiac isoforms of troponin T, myoglobin, and GAPDH were elevated in adult cardiomyocytes, while their level in neonatal cells remained unchanged. Obtained data contribute to the understanding of the mechanisms of neonatal cardiomyocytes' resistance to hypoxia and the ability to maintain the metabolic homeostasis in contrast to adult ones.
Studies have shown that the abnormal expression of circular RNA (circRNA) is inextricably linked to hepatocellular carcinoma (HCC). Recently, hsa_circ_0000518 (circ_0000518) was discovered in many cancer progressions. However, its function in HCC is still unclear. Through GEO database analysis combined with gene expression detection of HCC related clinical samples and cell lines, we identified that circ_0000518 was abnormally overexpressed in HCC. Cell and animal model experiments jointly indicated that circ_0000518 can stimulate HCC cell proliferation, migration, invasion and suppress apoptosis. Furthermore, we also found that knocking down the circ_0000518 could inhibit the Warburg effect in HCC cells. Mechanistically, circ_0000518 was found to be primarily localized in the cytoplasm, and sponge hsa-miR-326 (miR-326) promoted integrin alpha 5 (ITGA5) expression. In addition, circ_0000518 could enhance the stability of HuR-mediated ITGA5 mRNA, thereby activating the Warburg effect. In conclusion, this study elucidated that circ_0000518 was a cancer-promoting circRNA, which could enhance ITGA5 expression through competing endogenous RNAs (ceRNA) and RNA Binding Protein (RBP) mechanisms, thus facilitating the development of HCC. It provides a meaningful diagnostic and therapeutic target for HCC.
Fenofibrate Capsules (micronized), is a lipid regulating agent available as capsules for oral administration. Each capsule contains 67 mg, 134 mg or 200 mg of micronized fenofibrate. The chemical name for fenofibrate is 2-[4-(4-chlorobenzoyl) phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester with the following structural formula:

The empirical formula is C20H21O4Cl and the molecular weight is 360.83; fenofibrate is insoluble in water. The melting point is 79-82°C. Fenofibrate is a white solid which is stable under ordinary conditions.

Inactive Ingredients: Each capsule also contains croscarmellose sodium, NF; hydroxypropyl methylcellulose, USP; magnesium sulfate, NF; microcrystalline cellulose, NF; and sodium lauryl sulfate, NF.
Seven healthy children will participate in the study. The children will participate as an outpatient basis with study days carried out in the Physiological Research Unit at the Hospital of Sick Children, Toronto, Canada. Inclusion criteria include: being healthy, not taking any medications, no recent weight changes, no history of significant illness, willing to participate in the study. Exclusion criteria were the presence of illness, significant weight change, not acceptance of the diet. Prior to enrolment, each subject will have to fill 3 days food record form to ensure his or her normal dietary behavior. The study will be explained to subjects and their parents/guardians, benefits and potential risks will be explained as well and written assent, from the children, and consent from parents will be obtained. Subjects will receive financial compensations. Each subject will receive compensation for participation. Each parent/guardian will be reimbursed for the transpiration/parking expenses and a meal each study day.
A vaccine for immunising a mammal against trypanosomiasis or leishmaniasis comprises an antigenic preparation obtained from protozoal flagellates of the Trypanosomatidae family other than those of the genus Trypanosoma or Leishmania, respectively, which are not pathogenic to the mammal to be immunised and an adjuvant therefor. The Examples describe the preparation of vaccines from flagellates of species of the genus Leptomonas and Crithidia. The preferred adjuvants are a saponin preparation and a higher alkyl quaternary ammonium compound.  The antigen preparation may be produced by killing the cells of the flagellates, e.g. by successive freezing and thawing, by freeze drying, by ultrasonic waves, or by treatment with formaldehyde; alternatively, the protozoal flagellates may be grown in a culture medium and the antigenic material may be isolated from the medium itself by appropriate techniques.  The vaccines may contain conventional excipients, e.g. bacteriostats or buffering agents.
We have previously demonstrated that the glucocorticoid receptor β (GRβ) isoform induces hepatic steatosis in mice fed a normal chow diet. The GRβ isoform inhibits the glucocorticoid-binding isoform GRα, reducing responsiveness and inducing glucocorticoid resistance. We hypothesized that GRβ regulates lipids that cause metabolic dysfunction. To determine the effect of GRβ on hepatic lipid classes and molecular species, we overexpressed GRβ (GRβ-Ad) and vector (Vec-Ad) using adenovirus delivery, as we previously described. We fed the mice a normal chow diet for 5 days and harvested the livers. We utilized liquid chromatography-mass spectrometry (LC-MS) analyses of the livers to determine the lipid species driven by GRβ. The most significant changes in the lipidome were monoacylglycerides and cholesterol esters. There was also increased gene expression in the GRβ-Ad mice for lipogenesis, eicosanoid synthesis, and inflammatory pathways. These indicate that GRβ-induced glucocorticoid resistance may drive hepatic fat accumulation, providing new therapeutic advantages.
An antimicrobial cleansing composition including (a) 20 to less than 60 wt. % of at least one alcohol selected from ethanol and propanol; (b) 0.5 to 10 wt. % of a surfactant selected from sulfate salt surfactants and amphoteric surfactants. The composition shows effective cleansing and antimicrobial properties. Hence, using this composition, it will no longer be required to provide in hospitals two separate dispensers one for foam soap and one for antimicrobial alcohol-based composition. The antimicrobial cleansing composition can be used for making foam. Also, a dispenser contains the above antimicrobial cleansing composition.
<P>PROBLEM TO BE SOLVED: To provide a healthy collagen cosmetic by establishing the method for producing nanoparticles of collagen, Chinese herb drug, bean curd refuse, non-chlorella, San-chi ginseng, neem, stevia leaf, Momordica grosvenori fruit powder, spore of Fomes japonicus and enzymes and establishing the method for the production of water having low molecular structure and the dispersion of the nanoparticles in the water.  <P>SOLUTION: The production method of the dry collagen cosmetic composed of nanoparticles comprises the mixing of a collagen or gelatin protein with spore of Fomes japonicus, San-chi ginseng powder or ginseng known as Chinese herb drugs, agrochemical-free rice bran, bean curd refuse, non-chlorella, sea grass, urea, Canarium album powder, loquat leaf, vanillin, neem leaf and perfume, the super-cooling of the mixture with a liquefied gas, the pulverization with a mixer, the fractionation of the nanoparticle powder having particle size of 0.04-0.01μm and the sealing of the particles in dried state. The face lotion composed of a combination of water having low molecular structure with the cosmetic is produced by adding the collagen liquid to a degradation-resistant water containing 5-10% nano-low-molecular structure water of fresh water obtained by passing through nanoholes and adding the mixture to the cosmetic. The medicinal face lotion improves the impregnating property by docking to an automatic nerve. A medicinal cosmetic cream for preventing the insect bite of the face and hand is produced by including a vermin exterminating and repelling agent, and a preventive cosmetic for atopic dermatitis and athlete's foot is also produced by the method. For decreasing the amount of neem in the vermin exterminating and repelling agent, other repellent is added or mixed to the agent to obtain a harmless product having increased synergic effect or an agricultural repellent is dispersed in water together with powder and sprayed to the target.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
OBJECTIVES: A high proportion of women with advanced epithelial ovarian cancer (EOC) experience weakness and cachexia. This relationship is associated with increased morbidity and mortality. EOC is the most lethal gynecological cancer, yet no preclinical cachexia model has demonstrated the combined hallmark features of metastasis, ascites development, muscle loss and weakness in adult immunocompetent mice.
METHODS: Here, we evaluated a new model of ovarian cancer-induced cachexia with the advantages of inducing cancer in adult immunocompetent C57BL/6J mice through orthotopic injections of EOC cells in the ovarian bursa. We characterized the development of metastasis, ascites, muscle atrophy, muscle weakness, markers of inflammation, and mitochondrial stress in the tibialis anterior (TA) and diaphragm ∼45, ∼75 and ∼90 days after EOC injection.
RESULTS: Primary ovarian tumour sizes were progressively larger at each time point while severe metastasis, ascites development, and reductions in body, fat and muscle weights occurred by 90 Days. There were no changes in certain inflammatory (TNFα), atrogene (MURF1 and Atrogin) or GDF15 markers within both muscles whereas IL-6 was increased at 45 and 90 Day groups in the diaphragm. TA weakness in 45 Day preceded atrophy and metastasis that were observed later (75 and 90 Day, respectively). The diaphragm demonstrated both weakness and atrophy in 45 Day. In both muscles, this pre-severe-metastatic muscle weakness corresponded with considerable reprogramming of gene pathways related to mitochondrial bioenergetics as well as reduced functional measures of mitochondrial pyruvate oxidation and creatine-dependent ADP/ATP cycling as well as increased reactive oxygen species emission (hydrogen peroxide). Remarkably, muscle force per unit mass at 90 days was partially restored in the TA despite the presence of atrophy and severe metastasis. In contrast, the diaphragm demonstrated progressive weakness. At this advanced stage, mitochondrial pyruvate oxidation in both muscles exceeded control mice suggesting an apparent metabolic super-compensation corresponding with restored indices of creatine-dependent adenylate cycling.
CONCLUSIONS: This mouse model demonstrates the concurrent development of cachexia and metastasis that occurs in women with EOC. The model provides physiologically relevant advantages of inducing tumour development within the ovarian bursa in immunocompetent adult mice. Moreover, the model reveals that muscle weakness in both TA and diaphragm precedes severe metastasis while weakness also precedes atrophy in the TA. An underlying mitochondrial bioenergetic stress corresponded with this early weakness. Collectively, these discoveries can direct new research towards the development of therapies that target pre-atrophy and pre-severe-metastatic weakness during EOC in addition to therapies targeting cachexia.
1379730 Steroid anaesthetic compositions GLAXO LABORATORIES Ltd 16 Dec 1971 [17 Dec 1970] 60067/70 Heading ASB An anaesthetic composition suitable for use by injection comprises 3a-hydroxy-5a-pregnane-11, 20-dione in solution in an inert organic liquid injection medium. Water-soluble organic liquids may be employed, in which case water may be present in the solution. Specified watersoluble organic liquids are C 1 -C 6  diof polyhydric alcohols, glycerol formal, water-soluble amides (e.g. nicotinamide or N-#-hydroxyethyl lactomide) and water-soluble esters, e.g. ethyl lactate. Alternatively, water-insoluble organic liquids may be employed, especially oils such as fatty alcohols and their esters, fatty acid esters (including alkyl esters of fatty acids and vegetable oils) and hydrocarbons (including liquid paraffin, squalane, n-dodecane, n-hexadecane). Such oil solutions of steroid may be employed in the form of an aqueous emulsion wherein the oil is the continuous of the disperse phase. Such emulsions may contain a surface active component, e.g. a polyoxyethylated derivative of a fatty glyceride oil, a polyoxyethylene ether of a fatty alcohol, or polyoxyethylenepolyoxypropylene ether, a polyoxyethylated fatty acid ester of sorbiton or mannitan, a polyethylene glycol ester of a fatty acid or a phospholified. Additional ingredients which may be present are emulsion stabilising agents, surface disordering agents and additional steroids. Water-soluble substances such as dextrose, glycerol and sodium chloride, serving to render the compositions approximately isotonic with blood, may also be present. The composition may be made up in unit dosage form.
Caregiver and child pairs will complete a 14 week virtual, self-guided healthy lifestyle program including education on health and wellness topics such as food groups, physical activity and stress management. Special skill builders for managing the thoughts, feelings and emotions associated with changing health behaviors will also be included. Pairs will have biweekly 15 minute coaching sessions to check in on progress in the past week, set goals and problem solve. Optional group sessions will be offered for peer support. In order to assess progress, pairs will also complete assessment visits before and after the program. These visits include one virtual assessment via Zoom and one in-person assessment at the University of Alabama at Birmingham. Caregivers and children will complete questionnaires and measures such has height, weight, blood pressure and a finger prick.
Intubated and mechanically ventilated infants with respiratory failure (age \< 1 year old). see inclusion-exclusion criteria.
BACKGROUND: Ultrasound imaging is the most frequently performed for the patients with chronic hepatitis or liver cirrhosis. However, ultrasound imaging is highly operator dependent and interpretation of ultrasound images is subjective, thus well-trained radiologist is required for evaluation. Automated classification of liver fibrosis could alleviate the shortage of skilled radiologist especially in low-to-middle income countries. The purposed of this study is to evaluate deep convolutional neural networks (DCNNs) for classifying the degree of liver fibrosis according to the METAVIR score using US images.
METHODS: We used ultrasound (US) images from two tertiary university hospitals. A total of 7920 US images from 933 patients were used for training/validation of DCNNs. All patient were underwent liver biopsy or hepatectomy, and liver fibrosis was categorized based on pathology results using the METAVIR score. Five well-established DCNNs (VGGNet, ResNet, DenseNet, EfficientNet and ViT) was implemented to predict the METAVIR score. The performance of DCNNs for five-level (F0/F1/F2/F3/F4) classification was evaluated through area under the receiver operating characteristic curve (AUC) with 95% confidential interval, accuracy, sensitivity, specificity, positive and negative likelihood ratio.
RESULTS: Similar mean AUC values were achieved for five models; VGGNet (0.96), ResNet (0.96), DenseNet (0.95), EfficientNet (0.96), and ViT (0.95). The same mean accuracy (0.94) and specificity values (0.96) were yielded for all models. In terms of sensitivity, EffcientNet achieved highest mean value (0.85) while the other models produced slightly lower values range from 0.82 to 0.84.
CONCLUSION: In this study, we demonstrated that DCNNs can classify the staging of liver fibrosis according to METAVIR score with high performance using conventional B-mode images. Among them, EfficientNET that have fewer parameters and computation cost produced highest performance. From the results, we believe that DCNNs based classification of liver fibrosis may allow fast and accurate diagnosis of liver fibrosis without needs of additional equipment for add-on test and may be powerful tool for supporting radiologists in clinical practice.
BACKGROUND: Sodium-glucose co-transporter 2 inhibitors (SGLT2is) are part of the standard of care for patients with chronic kidney disease (CKD), both with and without type 2 diabetes. Endothelin A (ETA) receptor antagonists have also been shown to slow progression of CKD. Differing mechanisms of action of SGLT2 and ETA receptor antagonists may enhance efficacy. We outline a study to evaluate the effect of combination zibotentan/dapagliflozin versus dapagliflozin alone on albuminuria and estimated glomerular filtration rate (eGFR).
METHODS: We are conducting a double-blind, active-controlled, Phase 2b study to evaluate the efficacy and safety of ETA receptor antagonist zibotentan and SGLT2i dapagliflozin in a planned 415 adults with CKD (Zibotentan and Dapagliflozin for the Treatment of CKD; ZENITH-CKD). Participants are being randomized (1:2:2) to zibotentan 0.25 mg/dapagliflozin 10 mg once daily (QD), zibotentan 1.5 mg/dapagliflozin 10 mg QD and dapagliflozin 10 mg QD alone, for 12 weeks followed by a 2-week off-treatment wash-out period. The primary endpoint is the change in log-transformed urinary albumin-to-creatinine ratio (UACR) from baseline to Week 12. Other outcomes include change in blood pressure from baseline to Week 12 and change in eGFR the study. The incidence of adverse events will be monitored. Study protocol-defined events of special interest include changes in fluid-related measures (weight gain or B-type natriuretic peptide).
RESULTS: A total of 447 patients were randomized and received treatment in placebo/dapagliflozin (n = 177), zibotentan 0.25 mg/dapagliflozin (n = 91) and zibotentan 1.5 mg/dapagliflozin (n =  179). The mean age was 62.8 years, 30.9% were female and 68.2% were white. At baseline, the mean eGFR of the enrolled population was 46.7 mL/min/1.73 m2 and the geometric mean UACR was 538.3 mg/g.
CONCLUSION: This study evaluates the UACR-lowering efficacy and safety of zibotentan with dapagliflozin as a potential new treatment for CKD. The study will provide information about an effective and safe zibotentan dose to be further investigated in a Phase 3 clinical outcome trial.
CLINICAL TRIAL REGISTRATION NUMBER: NCT04724837.