anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The studies involving magnetocardiography have almost exclusively focused on evaluating possible clinical applications of the device. Leder et al saw the need for investigating the reproducibility of High Temperature Superconducting (HTS-)MCG measurements. They tested 18 healthy volunteers, stating that assessment of the reproducibility of HTS-MCGs in the normal heart is a prerequisite condition for the definition of significant levels of changes which, for instance, may be observed in serial measurements of patients suffering from acute coronary syndromes. They also pointed out the potentially strong electromagnetic interference inside a hospital, likely to be very different from the noise found in engineering laboratories where the MCGs are originally calibrated and tested. A respectable reproducibility for the MCG measurements is crucial for clinical applications. Leder et al studied the reproducibility of QRS complexes, ST segments, and T waves. They found that the reproducibility of the measurements in the depolarization phase was high, whereas the reproducibility of their repolarization readings was considerably lower. The results led Leder et al to conclude that further technical development was needed to improve signal-to-noise ratio allowing for clinical application of repolarization abnormalities for recognizing Acute Coronary Syndromes. In this study, we will focus on the repolarization phase by assessing the reproducibility of the T wave only. Comparison of scores and results based on computer analyses will provide the basis for our evaluation. Visual interpretations by the two examiners will also be compared.
Children aged six- to eight years-old, both gender, were selected from public schools of Piracicaba, SP, Brazil, and were divided in three groups: caries-free children (control group, GC), children with at least one primary molar with dentin caries lesion submitted to oral health educational strategy followed by ART (GS+ART), and the other group was directly submitted to ART (GART). Oral hygiene was assessed by the presence of biofilm and gingivitis in buccal surfaces of primary and/or permanent upper incisors. Oral health educational strategy consisted of four consecutive sessions (once a week) about etiological factors of caries (using visual aids), oral hygiene instructions (using models), supervised toothbrushing and explanation of ART (indications and stages). ART was performed using hand instruments for opening and cleaning the cavities and a high-viscosity glass-ionomer for restoration. Dental anxiety was assessed by measuring the cognitive (modified Venham Picture Test, m-VPT), behavioral (modified Venham Anxiety Scale, m-VAS) and physiological (heart rate, HR; salivary cortisol and alpha-amylase, SC and SAA) aspects in the following days and moments: D1 - baseline, a day preceding ART (SC and SAA); D2 - day of treatment, before strategy (m-VPT), before ART (m-VPT, HR, SC, SAA), during the explanation of procedure (HR, m-VAS), at the moment of deepest excavation (HR, m-VAS), at the moment the restoration was applied (HR, m-VAS), after ART (m-VPT, HR, SC, SAA). The following variables were evaluated in three moments: T1 - baseline, T2 - one week after strategy (for both GC and GART) and T3 - one month after the strategy or ART for GC and GART, respectively. Oral health-related quality of life was assessed using Brazilian short version of the Child Perceptions Questionnaire (16-CPQ8-10) with 16 items. Salivary flow rate was estimated by chewing 0.3g of an inert and tasteless material, for approximately 70 cycles/min and spitting all the saliva produced for five minutes into a cooled tube. Salivary pH was determined immediately after collection, using a portable pH-meter. Salivary buffer capacity was performed by adding 1.5 ml of HCl/5 mM to a tube containing 0.5 mL of stimulated saliva. For detection and quantification of S. mutans, the microbial DNA in unstimulated saliva samples was isolated and subjected to quantitative PCR reactions (qPCR).
PROBLEM TO BE SOLVED: To provide a structure of release paper by which only a pick-up piece on an upper side can be rolled up simply while eliminating wasting of the material of the release paper as for the structure of the two-sheet type release paper of an adhesive sheet. SOLUTION: The adhesive sheet has first release paper 20 and second release paper 21 to be stuck to the adhesive surface of the adhesive sheet. The first release paper has a first pick-up piece 22 to be folded back at the end part and the second release paper has a second pick-up piece 23 to be superposed on the first pick-up piece. The end edge shape 25 of the first pick-up piece is in the shape of a recessed and projecting line consisting of projecting parts and recessed parts continued alternately, the end edge shape 26 of the second pick-up piece is in a shape complimentary to the end edge shape of the first pick-up piece, The first pick-up piece and the second pick-up piece are arranged with their respective projecting parts and the recessed parts at the end edges shifted from each other.  The end edge shape of the second pick-up piece can be the same as that of the first pick-up piece. It is desirable that the second pick-up piece is superposed on the first pick-up piece by a length as long as the folding-back part of the first pick-up piece.
1,247,899. Cephalosporanic acid derivatives. CIBA-GEIGY A.G. 30 Dec., 1968 [2 Jan., 1968; 16 Sept., 1968], No. 61557/68. Heading C2A. Novel cephalosporanic acid derivatives of the general formula wherein R 1  is an imidazolium or imidazolyl group which may be hydrogenated and/or substituted and which is bonded to the acetylamino group by a nitrogen atom, and wherein R 2  is a free hydroxyl group or a hydroxyl group esterified by a carboxylic acid, in which ester oxygen atoms may be replaced by sulphur atoms, an optionally N-substituted carbamoyloxy group in which oxygen atoms may be replaced by sulphur atoms, or a quaternary ammonium group or a salt thereof are prepared by reacting a compound having the general formula wherein Z is a halogenacetyl radical and R 2  is as above defined, with an optionally hydrogenated and/or substituted imidazole or when Z is H the compound of Formula II is acylated by the group R 1 CH 2 CO- in which R 1  represents an imidazolyl group which may be hydrogenated and/or substituted, and, if desired, the resulting compound may be converted to a compound having a different group R 2  by known methods. The acylation may be carried out via a silylizing or stannylizing step. The starting material 3-(desacetoxymethyl)-3- benzoylthiomethyl - 7 - bromoacetylaminocephalosporanic acid is prepared by adding a solution of 3-(desacetoxymethyl)-3-benzoylthiomethyl 7 - amino - cephalosporanic acid and triethylamine in dimethylformamide to a solution of bromacetyl bromide in methylenechloride. A pharmaceutical composition comprises as active ingredient a novel compound of general Formula I above and a pharmaceutical excipient. The novel compounds are also stated to be of use in animal fodders and in additives to animal fodders.
The medical treatment of hemophilia has advanced greatly in recent years. There are now medications that reduce the physical symptoms of hemophilia. Nevertheless, those affected by hemophilia suffer from restricted mobility, reduced strength, reduced balance and pain as a result of the repeated bleeding. In order to make well-founded decisions regarding possible supportive therapeutic or medical measures, it is important to be able to estimate the extent of such limitations and whether these will change or remain stable.

The study is needed to validate the measurement properties of measurement instruments used to measure the effects of physical training interventions in participants with hemophilia. Clinical questions can only be solved if measuring instruments with sufficient measuring properties are used. These measurement properties must be evaluated in a relevant population. Otherwise, health professionals cannot assess whether measures or treatment are not effective or whether measured changes are not large enough to detect an actual change. Therefore, research is required to ensure that adequately studied measurement instruments are available for clinical assessment of those affected by adult participants with hemophilia.

Some of the tests (such as the Unipedal Stance Test or Four Square Step Test) have already been studied in children with hemophilia or in participants with other diseases. Since hemophilia is a disease with specific effects, the measuring instruments must also be researched in this participant group. There is still a research gap that the investigators would like to close with this study. For the study, the investigators selected tests that are already being used on adult participants with hemophilia and have had good experiences in practice. The tests are safe and can be carried out with little strain.
This is a clinical trial. The study population comprises all adult dysphagic patients who present laryngotracheal penetration and/or aspiration of liquids during the videodeglutogram exam, performed at the aforementioned Imaging Diagnosis Center, during the period from March to December 2023 and who agree to participate. Therefore, a convenience sample will be used.

The study population will consist of all patients who present laryngotracheal penetration and/or aspiration of liquids during the videodeglutogram exam performed at the institution's Imaging Diagnosis Center and who agree to participate in the study. The anamnesis was constructed by the research team, aiming to collect information about the target population (age, sex, marital status, education, underlying pathology, main complaint and swallowing difficulties). In addition, for those who have a history in the electronic medical record, the same will be consulted to verify information regarding the history of previous illnesses, medications in use and general health conditions. The examination will be performed by the technically responsible speech therapist, with experience in the area. It consists of offering food to the patient (thin liquid - water, moderately thickened - yogurt, soft solid - bread and hard - crackers), impregnated with a barium contrast; during swallowing, dynamic, real-time images are captured by an x-ray equipment, making it possible to evaluate all phases of swallowing, following the path of the food from the mouth to the stomach. The following aspects will be checked: oral preparation of the food, ejection of the bolus, the existence of early food escape and identification of the location of the beginning of the pharyngeal phase of swallowing, the presence of stasis in valleculae and pyriform sinuses, episodes of laryngotracheal penetration and/or aspiration, and changes in esophageal motility. Some compensatory strategies, such as head positioning and airway protection maneuvers, may be tested during the examination. Patients who present laryngotracheal penetration and/or aspiration with thin liquid will be subjected to the ingestion of carbonated water in order to verify whether there will be a change in the pattern of laryngotracheal penetration and/or aspiration. The carbonated water chosen for the study was the brand; for every 60ml of water, 1.8ml of barium (3% concentration) will be mixed, the contrast required for the images to be captured in the videofluoroscopy examination. To classify the functional severity of dysphagia and describe laryngotracheal penetration and/or aspiration, the following scales will be considered: Dysphagia Outcome and Severity Scale (DOSS) and Rosenbek Scale. The classification for evaluating the biomechanics of swallowing will be made based on the results of the videofluoroscopy exam, which will be performed.
In the literature we find no specific information on the psychic and social repercussions of the lymphœdema for the child who is affected. If the psychic and social repercussions of the secondary lymphœdema in the breast cancer are well known, very few things are it on those of the primary lymphœdema. Some studies estimate globally the quality of life of the patients with a lymphœdema whatever is the origin and the etiologie. These studies of money groups suggest that the psychic difficulties and of therapeutic care are not identical. A single study approaches the specific question of the lymphœdema of the child by focusing on the real-life experience of expanding child of a primary lymphœdema.The construction and the validation of a tool measuring the quality of life of the children and the young adults affected by lymphœdema congenital appears as a starting point. A tool which would first of all allow to make the current situation for the regional level, and then can envisage national actions common. According to recent studies, the evolution of the lymphoedema is different according to the forms of initial clinical expression of the lymphoedema, we wish we can thus know during this study the impact of these various clinical forms on the quality of life of the patients. A genetic collection will be realized for that purpose (genetic research).
Participants will receive venetoclax no more than 600 milligrams (mg) orally once daily continuously along with rituximab 375 milligrams per square meter (mg/m\^2) intravenous (IV) infusion on Day 1 of 28-day cycle and bendamustine 90 mg/m\^2 IV infusion on Days 1 and 2 of the 28-day cycle. Safety run-in will continue until first 9 participants complete the safety observation window of 28 days. Participants will continue receiving the same treatment as decided for Arm B.
Increasing evidence has shown that physical activity is related to a lower risk of chronic kidney disease (CKD), thus indicating a potential target for prevention. However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. Mendelian randomization (MR) analysis was used to determine the causal relationship between physical activities and kidney function. Two-sample MR genetically predicted that heavy DIY (do it yourself) (e.g., weeding, lawn mowing, carpentry, and digging) decreased the risk of CKD (odds ratio [OR] = 0.287, 95% CI = 0.117-0.705, p = 0.0065) and improved the level of eGFR (β = 0.036, 95% CI = 0.005-0.067, p = 0.021). The bidirectional MR showed no reverse causality. It is worth noting that other physical activities, such as walking for pleasure, strenuous sports, light DIY (e.g., pruning and watering the lawn), and other exercises (e.g., swimming, cycling, keeping fit, and bowling), were not significantly correlated with CKD and eGFR. This study used genetic data to provide reliable and robust causal evidence that heavy physical activity (e.g., weeding, lawn mowing, carpentry, and digging) can protect kidney function and further lower the risk of CKD.
Sodium Chloride Injection, USP, 23.4%, is indicated as an additive in parenteral fluid therapy for use in patients who have special problems of sodium electrolyte intake or excretion. It is intended to meet the specific requirements of the patient with unusual fluid and electrolyte needs. After available clinical and laboratory information is considered and correlated, the appropriate number of milliequivalents of sodium chloride required can be withdrawn from Sodium Chloride Injection, USP, 23.4% and diluted for use.

Sodium Chloride Injection is indicated for the treatment of sodium, chloride and water deficiencies that commonly occur in many diseases. Isotonic Sodium Chloride Injection should be limited to cases in which the chloride loss is greater than the sodium loss, as in vomiting from pyloric obstruction, or in which the loss is about equal, as in vomiting from duodenal, jejunal or ileal obstruction and in the replacement of aspirated gastrointestinal fluids.

The toxic symptoms that follow various forms of intestinal obstruction are accompanied by a marked reduction of blood chloride and often sodium chloride has a lifesaving effect.

Symptoms of sodium chloride deficiency are very similar to those of Addison’s disease and large doses of sodium chloride will produce temporary alleviation of the symptoms. Other disorders in which sodium chloride is therapeutically useful include extensive burns, failure of gastric secretion and postoperative intestinal paralysis.
Metformin Hydrochloride (herein referred to as metformin HCl) that may be 98.5%-100% pure is a high dose drug capable of being directly compressed with specific excipients into tablets having desired, hardness, disintegrating ability, and acceptable dissolution characteristics. Metformin HCl is not inherently compressible and thus presents formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow metformin HCl to be compressed using the direct compression method. The tablets produced provide an acceptable in-vitro dissolution profile.
Brain fog is a condition that is characterized by poor concentration, memory loss, decreased cognitive function, and mental fatigue. Although it is generally known as a long-term COVID-19 symptom, brain fog has also been reported to be caused by many other diseases. Thus, it is necessary to assess this condition in certain populations. This study aimed to evaluate the reliability and validity of the Brain Fog Scale in a Turkish population. We conducted the study in two phases. In a pilot study including 125 participants, we confirmed the suitability of the scale for validity analyses and then conducted exploratory (n = 230) and confirmatory factor analyses (n = 343). The Cronbach's alpha value of the 23-item Brain Fog Scale was 0.966. In addition, the 23-item and three-factor structure was confirmed as a result of the analyses. These three factors are mental fatigue, impaired cognitive acuity, and confusion. We also found that participants previously diagnosed with COVID-19 had higher brain fog scores. This finding indicates that brain fog is an important condition that can accompany COVID-19. Furthermore, this validated construct has an acceptable fit and is a valid and useful tool for the Turkish population.
The numerous shorts made of various clothes which are sold on the market are beautiful and comfortable, but are not able to achieve the function of sweat elimination, cooling, ventilation and miliaria prevention. A plurality of people are perplexed with the problems caused by the inability of the shorts in ventilation and the rinse of the sweat at the root part of the legs particularly in summer. The fat people are more particularly perplexed with the miliaria and tinea cruris, etc. at the root part of the legs. The main principle of the sweatless shorts is that the shorts are made through the combination of a spacing piece which is made from the mint leaf powder, the ginger powder, the purslane powder and mulberry tree leaf powder with the characteristics of the flax textiles. The sweatless shorts not only has beautiful figure and comfortable dressing, but also has the function of preventing the miliaria, tinea cruris, etc. through the different actions of a plurality plant spacing pieces, during ventilation, cooling and sweat elimination, thus being the first and best choice for people of both genders and various ages.
Provides financial support weekly in the form of a grocery benefit. The investigators will enroll participants in the Food Lion MVP program, linking the account to a Duke email address. The study team will work with the participants to order $50 worth of groceries from Food Lion, for the participants to pick up from the store. Groceries will be ordered weekly for the 12 months of enrollment and coordinators will have access to view items purchased at Food Lion by each participant.
A cohort of PWUD (N=500) living in Baltimore. We will follow-up with participants every 6 months (for 18 months) in five recruitment zones throughout Baltimore (n=125/zone). The four recruitment zones will overlap the intervention sites. There will be four study visits (baseline, 6 months, 12 months, 18 months) total for participants.
PURPOSE: This project aims to evaluate the relationship between biological sex and postoperative pain and in patients receiving posterior spinal fusion for adolescent idiopathic scoliosis.
METHODS: This is a retrospective study of patients (n=137) aged 10-17 receiving posterior spinal fusion for adolescent idiopathic scoliosis between 01/2018 and 09/2022. Each patient received surgery by the same pediatric orthopedic surgeon with identical postoperative pain management regimen at a children's hospital or a tertiary referral center with a pediatric spine program.
RESULTS: There were no significant differences in any background characteristics between the male and female patients, including age, BMI, number of levels fused, preoperative degree of scoliosis, and length of surgery and anesthesia (p>0.05). There were no differences in amount given of any intraoperative medications, nor in amount of postoperative scheduled analgesics (p>0.05). Female patients demonstrated higher average pain scores on Visual Analogue Scale evaluations during the first 24 hours postoperatively (5.0 vs 3.6, p<0.0001), 24-48 hours postoperatively (4.9 vs 4.0, p=0.03), and at the first physical therapy evaluation (5.3 vs 3.8, p<0.001). These patients received significantly greater amounts of morphine milligram equivalents in the first 24 hours postoperatively (42.2 vs 31.5, p=0.01) and for the hospitalization in total (63.8 vs 51.3, p=0.048). There was no difference in hours until hospital discharge (44.3 vs 42.6, p=0.62) nor until first ambulation (20.1 vs 21.3, p=0.24) between the female and male patients.
CONCLUSION: The influence of biopsychosocial factors on postoperative pain in adolescents is complex. This study adds to the existing pool of literature suggesting differences in pain perception between adolescent female and male patients. Female patients undergoing posterior spinal fusion for adolescent idiopathic scoliosis may benefit from increased preoperative counseling and more aggressive intra- and postoperative pain management regimens.