anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a bath agent capable of accelerating the extraction of active ingredients by sealing the lyophilization product of a fragrant grass such as mint in a bag. CONSTITUTION: This bath agent is obtained by sealing the lyophilization product powder of a fragrant grass such as the grass of the Mentha, Pelargonium, Foeniculum or Anethum in a bath agent bag formed from a net-like web comprising hydrophobic fibers. The lyophilization product powder of the fragrant grass is obtained by lyophilizing the fragrant grass in the raw state, drying the lyophilization product under a vacuum of 0.1-5mmHg at 0-30 deg.C and subsequently grinding the obtained vacuum-dried product having a water content of <=0.1wt.% into the powdery product having a density of 1.0mm<2> . The ground product is charged in a bag formed from a web having an air-permeability of approximately 300-3000 ml/sec.cm<2> , such as a non-woven fabric.  A water-soluble compound (e.g. sodium carbonate) generating a gas when contacting with water or a sinker formed by molding the water-soluble compound into a tablet-like product is also charged in the bag so that the bag sinks in water. The employment of the lyophilization product as the dry powder of the fragrant grass enables to profitably reduce the amount of the grass in comparison with the natural dried product of the grass, and to easily recover the bath agent after used, because the used bath agent is floated up on the surface of the bath.
The invention discloses a Chinese herbal medicine acne-removing composition and application thereof, belonging to the technical field of traditional Chinese medicines. Comprises the following raw materials: parched fructus Xanthii, flos Lonicerae, radix Arnebiae, Glycyrrhrizae radix and Scorpio, and also provides different raw material ratios for topical and oral pills. The invention adopts the acne-removing principle of treating both principal and secondary aspects of a disease by oral administration and external application. The growth of pox is closely related to the dysfunction of viscera although on the skin surface, and the traditional Chinese medicine is used for regulating the body, so that toxin is removed in the body, the channels and collaterals are regulated, the functions of viscera are normal, the problem of excessive sebum secretion of sebaceous glands is fundamentally solved, and the external application medicine is matched. The acne, comedo and whelk can be thoroughly removed by the inner and outer double tubes. The Chinese herbal medicine acne-removing composition disclosed by the invention is prepared by supplementing pills for oral administration and external application, and has a short curative effect and a quick response compared with a single Chinese medicine for oral administration or a Chinese medicine mask by virtue of an internal and external integrated treatment principle.
Camp members will receive information about HIV self-testing from peer educators who will be nominated by you and other camp members in your camp. Camp members in the STEP project will receive pretest counseling and a 10 minute demonstration. They will receive 1 oral fluid HIV self-test kit to conduct the self-test at home or in a private location during the next 1 month and a phone number to call in case you need assistance when performing the self-test at home. They will also receive information about the nearest HIV Care and Treatment Center where they can seek a confirmatory HIV test and start HIV treatment in the event of a positive self-test result.
YL202 is provided as the lyophilized powder, 200 mg/vial. HR-positive breast cancer with HER2-Zero-expression and HER2-Low-expression patients will be given YL202 by intravenously once every 3 weeks (Q3W) as a cycle.
A fusion protein for restoring functions of failing immune cells and application thereof. The fusion protein has a functional area for recognizing the failing immune cell and a functional area for conducting activation and amplification on the failing immune cell. The two functional areas are connected through a non-functional amino acid fragment with a certain length. The functional area for recognition uses the immune checkpoint specific antibody to recognize a phenotypic receptor of failing immune cells. The functional area for conducting activation and amplification adopts the cytokine or functionally-similar mutants, a ligand of the phenotypic receptor or functionally-similar mutants or an activating antibody to activate failing immune cells. The fusion protein recognizes failing immune cells, conducts activation and amplification on recognized failing immune cells, restores functions of killing antigen positive cells by the immune cells, and enhances inhibition of tumor growth and virus infection control.
The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25 % T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/or greater than 50 % c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.
BACKGROUND: A high-frequency point-of-care (POC) ultrasound instrument was used to evaluate the microstructural and biomechanical properties of the anterior sclera in vivo using parameters computed from quantitative ultrasound (QUS) methods.
METHODS: In this cross-sectional study, both eyes of 85 enrolled patients were scanned with the POC instrument and ultrasound data were processed to obtain QUS parameters. Pearson correlation and multi-linear regression were used to identify relationships between QUS parameters and refractive error (RE) or axial length. After categorising eyes based on RE, binary support vector machine (SVM) classifiers were trained using the QUS or ophthalmic parameters (anterior chamber depth, central corneal thickness, corneal power, and intraocular pressure) to classify each eye. Classifier performance was evaluated by computing the area under the receiver-operating characteristic curve (AUC).
RESULTS: Individual QUS parameters correlated with RE and axial length (p < 0.05). Multi-linear regression revealed significant correlation between the set of QUS parameters and both RE (R = 0.49, p < 0.001) and axial length (R = 0.46, p = 0.001). Classifiers trained with QUS parameters achieved higher AUC (𝑝 = 0.06) for identifying myopic eyes (AUC = 0.71) compared to classifiers trained with ophthalmic parameters (AUC = 0.63). QUS-based classifiers attained the highest AUC when identifying highly myopic eyes (AUC = 0.77).
CONCLUSIONS: QUS parameters correlate with progressing myopia and may be indicative of myopia-induced microstructural and biomechanical changes in the anterior sclera. These methods may provide critical clinical information complementary to standard ophthalmic measurements for predicting myopia progression and risk assessment for posterior staphyloma formation.
Depression is a serious medical condition. It occurs in people of all ages, but only in the past two decades has depression in children and adolescents been taken seriously. Children and adolescents with depression may exhibit such behaviors as pretending to be sick, refusing to go to school or getting in trouble at school, clinging to a parent or worrying that the parent may die, sulking, or acting in a negative or grouchy manner. A previous study demonstrated that, when administered by clinicians in school-based clinics, individual interpersonal psychotherapy is effective in reducing depressive symptoms and improving global and social functioning. This study will assess the effectiveness of group interpersonal psychotherapy (IPT-AG) versus treatment as usual (TAU) in improving depressive symptoms of adolescents in school-based health clinics.

Participants in this 16-week single-blind study will be randomly assigned to receive either IPT-AG or TAU in a school-based clinic. Participants assigned to receive IPT-AG will attend two to three, 40-minute individual pre-group sessions, followed by 12, 90-minute group therapy sessions and two additional individual sessions-one midway through the group sessions and another upon completion of group therapy. TAU will consist of counseling sessions as regularly conducted by the school clinic social worker and/or referral to another agency. Study visits will occur at baseline and Weeks 4, 8, 12, and 16, or upon early termination. At the end of 16 weeks, participants assigned to receive IPT-AG will continue in a maintenance program in which they will receive IPT-AG once a month for an additional 6 months. All participants will also be assessed 6 and 12 months post-treatment to measure depressive symptoms, global and social functioning, satisfaction with care, and utilization of other services.
Menopause is associated with reduced endothelial-dependent vasodilation and increased cardiovascular disease (CVD) risk. Dietary nitrate, a non-pharmacological approach, may increase vasodilatory capacity consequentially reducing CVD risk. We investigated macro- and microvascular function after acute nitrate supplementation in postmenopausal females (PMF). Vascular function was studied with flow-mediated vasodilation (FMD) and near-infrared post occlusive reactive hyperemia (PORH). Incremental handgrip exercise was performed to investigate blood flow and tissue oxygenation. We hypothesized acute dietary nitrate would not impact resting endothelial measures but would increase post ischemic vasodilation and incremental exercise blood flow. Late-phase PMF (n = 12) participated in a randomized crossover design with 140 mL of nitrate-rich (NR) beetroot juice or nitrate-poor black currant juice. Testing included a 5-min FMD, a 3-min ischemic exercise FMD, and incremental exercise at 10%, 15%, and 20% maximal voluntary contraction to measure blood flow and pressure responses. A p ≤ 0.05 was considered significant. One-way ANOVA indicated lower resting pressures, but no change to FMD, or PORH in either protocol. Two-way repeated measures ANOVA indicated NR supplementation significantly reduced mean arterial pressure at rest and during incremental exercise at all intensities without changes to blood flow. Acute nitrate is effective for resting and exercising blood pressure management in PMF.
The adhesive side of Vivelle-Dot® (estradiol transdermal system) should be placed on a clean, dry area of the abdomen. Vivelle-Dot should not be applied to the breasts. Vivelle-Dot should be replaced twice weekly. The sites of application must be rotated, with an interval of at least 1 week allowed between applications to a particular site. The area selected should not be oily, damaged, or irritated. The waistline should be avoided, since tight clothing may rub the system off. The system should be applied immediately after opening the pouch and removing the protective liner. The system should be pressed firmly in place with the palm of the hand for about 10 seconds, making sure there is good contact, especially around the edges. In the event that a system should fall off, the same system may be reapplied. If the same system cannot be reapplied, a new system should be applied to another location. In either case, the original treatment schedule should be continued. If a woman has forgotten to apply a patch, she should apply a new patch as soon as possible. The new patch should be applied on the original treatment schedule. The interruption of treatment in women taking Vivelle-Dot might increase the likelihood of breakthrough bleeding, spotting and recurrence of symptoms.
The present invention discloses a pollen nutrition composition, a pollen mask and preparation methods thereof, and relates to the field of pollen products. The pollen nutrition composition is prepared from filtering residues prepared by an extraction process of pollens. Every 1,000 parts by mass of the composition comprises the following raw materials: 300-500 parts of filtering residues, 10-20 parts of carboxymethyl chitosan, 1-2 parts of a food emulsifier, 50-100 parts of edible alcohol at a purity of 95% or more, 0.2-0.5 part of a food defoamer, and the balance being water. The pollen nutrition composition is a paste which is delicate in texture, loose and porous. The pollen nutrition composition is coated on the surface of skin, can absorb excessive oil, and conducts a deep cleaning of the skin. The filtering residues also contain 5%-10% of pollen internal nutrients and can supplement nutrients of the skin. The prepared pollen mask from the pollen nutrition composition can supplement nutrition for the skin, at the same time conducts the deep cleaning for the skin, and has a good skin caring effect.
Self-management of postnatal anti-hypertensive treatment. Women will be provided with, and taught to use, a validated home blood pressure monitor, and perform daily BP readings. When treatment is discontinued we will ask them to continue daily BP measurements for 1 week. Provided these are \<140/90 mmHg they will be asked to check their BP weekly for the remainder of the trial period. The self-monitoring BP data will be collated centrally through the use of a smart phone app or SMS based system. This service will respond to participants regarding the level of their BP and what action is required. Women in the self-management group will have an individualised medication adjustment schedule developed by the research team in conjunction with the participant's obstetric team.
To provide a sanitary mask capable of sufficiently giving the prevention of skin roughness or the like and the beauty effect even when worn for a long time.SOLUTION: A sanitary mask is composed of a mask body 1 and an ear strap 2. The mask body 1 is formed of a nonwoven fabric body having a three-layer structure in which an inner layer 3, an intermediate layer 4, and an outer layer 5 are laminated in this order from the skin side. The intermediate layer 4 is made of a nonwoven fabric which is composed of ultrafine fibers and is a melt-blown nonwoven fabric. The inner layer 3 and the outer layer 5 are made of a nonwoven fabric which is composed of a thicker fineness fiber than the ultrafine fiber and is a spunbonded nonwoven fabric or a thermal-bonded nonwoven fabric. A cosmetic agent containing glycerol and a cosmetic ingredient is applied to the inner layer 3. Dipropylene glycol, a L-glutamic acid derivative, an apple fruit cultured cell extract, hyaluronic acid, or the like is used as the cosmetic ingredient.SELECTED DRAWING: Figure 2
BACKGROUND: Delayed cerebral ischemia (DCI) is usually caused by cerebral vasospasm (CVS). To detect DCI and CVS, a cranial computed tomography (CT) scan will be performed, but cervical vessels are not necessarily displayed.
METHODS: A 63-year-old female patient who suffered from aneurysmal subarachnoid hemorrhage (SAH) was treated at the authors' institution. After an initially unremarkable clinical course, she developed aphasia on day 11. CT angiography (CTA) and perfusion imaging revealed significant hypoperfusion of the left hemisphere. In addition, the CTA showed a subtotal stenosis of the internal carotid artery (ICA) at the level of the petrous segment, suspicious for a dissection. This was not detectable angiographically in the final control of the intervention and was also not clinically evident until day 11.
RESULTS: Cerebral perfusion as well as the clinical symptoms normalized rapidly after stent reconstruction of the ICA.
CONCLUSION: Even though CVS is the most common cause of hypoperfusion in patients after an SAH, a peri-interventional dissection can also lead to relevant stenosis and thus to a disturbed cerebral perfusion and corresponding neurologic deficits. The time delay between the intervention and the clinical and CTA manifestation in our case is remarkable.
PURPOSE:An easily usable application agent for external use, containing a drug, polyhydric alcohol and adhesive excipient in a water-soluble protein having absorption promoting action, and capable of enhancing the bioavailability of the drug and understanding accurately the dose of the drug. CONSTITUTION:A solt application agent for external use, obtained by incorporating a drug, e.g. analgesic and anti-inflammatory agent, local anesthetic agent or antimicrobial agent, polyhydric alcohol, e.g. glycerol or PEG, and adhesive excipient, e.g. cellulose, polysaccharide or polyvinyl alcohol (PVA), in a water- soluble protein, e.g. gelatin, solubilized collagen or casein, and having individual tackiness to the skin. The incorporation of the water-soluble protein provides the application agent having remarkably improved drug absorbability, lasting property and bioavailability. The above-mentioned agent is produced by a simple and easy process. The resultant agent can be incorporated with even a liquid or low-melting drug which has not been easily incorporated with solid pharmaceuticals in the past.
Cardiovascular disease remains the leading cause of death in the United States and worldwide. Several studies have demonstrated that fruit and vegetable rich diets significantly reduced blood pressure and reduced the risk of ischemic stroke and cardiovascular disease in general, the exact mechanisms remain poorly understood. Preclinical and clinical research over the last decade has revealed the important vasoprotective effects of nitrates and nitrites with regards to reduction in blood pressure, vascular inflammation and endothelial dysfunction. More recent findings suggest that inorganic nitrate and nitrite therapy may be involved in the regulation of glucose-insulin homeostasis.

For this reason, development of an oral formulation of nitrite salt represents a rational avenue of exploration for the treatment of cardiovascular diseases, whereby nitrite would ensure rapid acting effects upon absorption. Nitrite could then be oxidized to nitrate via the enterosalivary circulation pathway. In this pathway, about 25% of circulating nitrate is concentrated in the saliva and reduced to nitrite by commensal mouth bacteria with nitrate reductase enzymes. The proposal will investigate the inorganic nitrite effects (in any form) on insulin sensitivity in a targeted population of overweight/obese adults with metabolic syndrome and hypertension, at risk for insulin resistance and endothelial dysfunction. This will be the third human trial using orally delivered nitrite (previously as aqueous solution).
Al18F-NOTA-FAPI PET/CT will be performed on patients with suspected or clearly diagnosed FAP positive-expressing tumors. The patients were injected with Al18F-NOTA-FAPI and underwent PET/CT scan 20\~40min after the injection.
Patients receiving a chemotherapy regimen including daunorubicin hydrochloride administered as an infusion of any duration \< 24 hours on a 1 or a 2 day schedule. Pre-study evaluations no greater than 14 days prior to daunomycin administration. If patients have had significant intercurrent illness or treatment that might affect organ function, laboratory work should be performed at an appropriately closer interval to daunomycin administration. A complete history and physical examination including height, weight and body surface area. Patients should be weighed with only light clothing; shoes must be removed before weight is measured. Patients height should be measured using a stadiometer after removing shoes. Laboratory evaluation: a) CBC with differential and platelet count. b) ALT, AST, bilirubin, creatinine, total protein, albumin, alkaline phosphatase, GGT.
Participants will undergo the InTone TM (InControl Medical, LLC) medical device treatment for Urinary Incontinence. The frequency of treatment is once/day (12 minutes), 5-6 days/week. The route of administration is vaginal.
In group B opioid based anesthesia is administered.Anesthesia and analgesia were achieved with remifentanil(0.3mcg/kg/minute), local anesthetic(ropivacaine 2mg/kg 0.75% wound infiltration), paracetamol(15mg/kg), non steroid analgesics(diclofenac 1mg/kg).Anesthesia induction with propofol 1% 2-3mg/kg,fentanyl(2mcg/kg), rocuronium 1mg/kg. Anesthesia maintenance with propofol 1% 10mg/kg/hour. Reversal of rocuronium with sugammadex 2mg/kg.
PURPOSE:To suitably realize the coating of a particulate material with a liquid by passing an air stream containing the particulate material in a dispersed state through a cylindrical body whose inner wall surface is wetted with a liquid to be applied and bringing the particulate material into contact with the coating liquid to dry the coated one. CONSTITUTION:In a dryer 5 having an internal space, a particulate material having a liquid bonded to the surface thereof is dried while suspended by an air steam. In the particulate material charging apparatus 2 connected to the upper part of the dryer 5, the air stream containing the particulate material in a dispersed state is charged in the above-mentioned space through a cylindrical passage. Further, the inner wall of the cylindrical passage of the apparatus 2 is wetted with a coating liquid by a liquid supply means 16. That is, the air stream containing the particulate material in a dispersed state is passed through the cylindrical passage whose inner surface is wetted with the coating liquid to bring the particulate material into contact with the coating liquid and, thereafter, the particulate material having the coating liquid bonded to the surface thereof is dried. As a result, the coating of the sufficiently dispersed particulate material with a desired liquid can be suitably realized.
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis. Most of the KDMs are Jumonji C domain-containing (JMJD) proteins. Many of these KDMs remove methyl groups from histone tails to regulate gene transcription. There are more than 30 known KDM proteins, which fall into different subfamilies. Of the many KDM subfamilies, KDM3 (JMJD1) proteins specifically remove dimethyl and monomethyl marks from lysine 9 on histone H3 and other non-histone proteins. Dysregulation of KDM3 proteins leads to infertility, obesity, metabolic syndromes, heart diseases, and cancers. Among the KDM3 proteins, KDM3A has been largely studied in cancers. However, despite a number of studies pointing out their importance in tumorigenesis, KDM3B and KDM3C are relatively overlooked. KDM3B and KDM3C show context-dependent functions, showing pro- or anti-tumorigenic abilities in different cancers. Thus, this review provides a thorough understanding of the involvement of KDM3B and KDMC in oncology that should be helpful in determining the role of KDM3 proteins in preclinical studies for development of novel pharmacological methods to overcome cancer.