anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Methods are provided for producing a population of substantially purified CD4+ Th1 lymphocytes. The method includes stimulating a population of substantially purified CD4+ T cells isolated from a subject by contacting the population with an anti-CD3 monoclonal antibody and an antibody that specifically binds to a T cell costimulatory molecule in the presence of a Th1 supportive environment to form a stimulated population of T cells. The stimulated population of CD4+ T cells is allowed to proliferate in a Th1 supportive environment. In one example, the Th1 supportive environment includes at least 20 IU/ml of IL-2, for example about 1000 I.U./ml of IL-2, and a neutralizing amount of an IL-4, an IL-13, and/or an IL-4/IL-13 neutralizing agent. In other examples, the supportive environment further includes at least 1 ng/ml of IL-12, for example about 2.5 ng/ml of IL-12. Purified populations of Th1 cells are disclosed herein, as are methods for their use.
The apelin receptor (APJ) is a key player in tumour angiogenesis, but its role in hepatocellular carcinoma (HCC) remains unclear. This study aims to elucidate the function of the apelin/APJ pathway in HCC using a multi-omics approach and identify potential therapeutic biomarkers. Differentially expressed genes related to the apelin/APJ axis were identified from bulk transcriptomics to reveal HCC-associated disparities. Single-cell and spatial transcriptomics were used to localize and analyse the function of these genes. Machine learning models were constructed to predict outcomes based on apelin/APJ expression, and experimental validation was conducted to explore the pathway's impact on HCC angiogenesis. Single cell analysis revealed an overexpression of APJ/Aplin in the endothelium. The stemness of endothelial cell (EC) with high apelin/APJ was enhanced, as well as the expression of TGFb, oxidative stresses and PI3K/AKT pathway genes. Spatial transcriptomics confirmed that EC populations with high APJ scores were enriched within the tumour. Machine learning models showed high prognostic accuracy. High APJ expression was linked to worse outcomes (p = 0.001), and AUC values were high (1 year, 3 year, 5 year) (0.95, 0.97, 0.98). Immune suppression and non-responsiveness of immune therapy were also seen in high-risk groups. The experimental validation showed that silencing apelin reduced angiogenesis (p  < 0.05), endothelial proliferation, decreased expression of ANG2, KLF2, VEGFA and lower ERK1/2 phosphorylation. Apelin may serve as a potential therapeutic target in HCC, given its role in promoting tumour angiogenesis and poor patient outcomes.
Citizens who received baseline cognitive assessment and evaluation of metabolic risk factors from the CUHK Brain Health Longitudinal Study. Baseline micro- and macro-cerebrovascular abnormalities were evaluated by MRI brain on recruitment and received COVID-19 vaccination (SinoVac or BioNTech).
BACKGROUND: Ferroptosis, a non-apoptotic form of regulated cell death, plays a critical role in the suppression of various tumor types, including ovarian cancer. Artesunate (ART), a derivative of artemisinin, exhibits extensive antitumor effects and is associated with ferroptosis. This study aimed to investigate the mechanisms through which ART induces ferroptosis to inhibit ovarian cancer.
METHODS: RNA sequencing was conducted to identify differentially expressed genes associated with ART-induced ferroptosis. Dual-luciferase reporter assays and electrophoretic mobility shift assays were performed to confirm the interaction between Homeobox C11 (HOXC11) and the Prominin 2 (PROM2) promoter. Cell Counting Kit-8 (CCK-8) assays, flow cytometry, and wound healing assays were used to analyze the antitumor effects of ART. Western blot, biochemical assays and transmission electron microscope were utilized to further characterize ART-induced ferroptosis. In vivo, the effects of ART on ferroptosis were examined using a xenograft mouse model.
RESULTS: RNA sequencing analysis revealed that the HOXC11, PROM2 and Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) pathways were downregulated by ART. HOXC11 was found to regulate PROM2 expression by binding to its promoter directly. HOXC11 overexpression reversed ART-induced effects on ovarian cancer cell proliferation, migration, apoptosis and ferroptosis by activating the PROM2/PI3K/AKT signaling axis. Conversely, silencing PROM2 in HOXC11-overexpressing cells restored ART-induced ferroptosis and its associated antitumor effects by inhibiting the PI3K/AKT pathway. Consistently, in vivo studies using a xenograft mouse model confirmed that ART-induced tumor inhibition was mediated by ferroptosis through the suppression of the HOXC11/PROM2/PI3K/AKT pathway.
CONCLUSION: This study identifies the HOXC11/PROM2/PI3K/AKT axis as a novel regulatory mechanism underlying ART-induced ferroptosis in ovarian cancer. Targeting the HOXC11/PROM2 axis may represent a promising therapeutic strategy for enhancing ferroptosis, offering new insights for the treatment of ovarian cancer.
The invention relates to the ingredients of an external-used medicine which is used for treating rheumatoid diseases and a preparation method thereof. The purpose of the invention is to provide the external-used medicine which is used for treating rheumatoid diseases and can improve the microcirculation and relieve the symptoms of the diseases by eliminating dampness after the medicine is applied externally and absorbed by the skin and the arthrosis. The external-used medicine used for treating rheumatoid diseases comprises the following ingredients: 6 grams of Araceae, Divaricate Saposhnikovia Root, Angelica dahurica Benth. et Hook, Rhizoma Gastrodiae, Notopterygium root and Rhizoma typhonii respectively which are cut into segments, 30g of slightly baked isinglass, 30g of baked-to-yellow West Lake lotus root powder, 30g of stir-baked copperas, 9g of vermilion, 5g of Xuchangqing, 5g of Balloon Flower, 10g of Caulis Lonicerae, 5g of Forsythia, 5g of Indian Dendranthema Flower, 10g of Trichosanthes Root, 5g of Calamus and 10g of Spina Gleditsiae. The medicine is ground into fine powder, and blended with hot liquor. After the ingredients are adopted, in treating the rheumatoid diseases caused by noxious dampness such as weak renal Qi, spasm of muscles, weak contraction bi, the medicine can realize addressing both the symptoms and root causes by integrating the effect of each raw material.
The invention discloses an acidum citricum hypoglossal tablet and the preparing method, relating to a tablet and the preparation method. The invention means to solve problems: current acidum citricum are all oral tablets and capsule, the content is large and increases liver injury, and it is easy to generate adverse effect. The comprised component and their weight proportion are as follows: acidum citricum 20 -30 units, manna sugar 45-65 units, lactin 65-105 units, sweetener 0. 5-1. 5 units, ethanol solution with concentration being 5%PVPK30 30 -40 units and dolomol 4-8 units. The preparation method comprises following steps: sifting sot material with nylon screen of 18-20 order to produce particular, drying at 55-65 Deg. C; sifting granular with screen of 14-16 order and placing for 5-7 hours for sheeting. The tablet is characterized by small content, increased biological utilization rate, low adverse effect rate, and the method is characterized by short and simple process.
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication in older patients with cancer and is associated with decreased quality of life and increased disability and mortality rates. Systemic inflammation resulting in neuroinflammation is considered important in the pathogenesis of POCD. The aim of this study was to explore the association between the early surgery-induced inflammatory response and POCD within 3 months after surgery in older cancer patients.
METHODS: Patients ≥65 years in need of surgery for a solid tumor were included in a prospective cohort study. Plasma levels of C-reactive protein (CRP), interleukin-1 beta (IL-1β), IL-6, IL-10, and Neutrophil gelatinase-associated lipocalin (NGAL) were measured perioperatively. Cognitive performance was assessed preoperatively and 3 months after surgery. POCD was defined as a decline in cognitive test scores of ≥25% on ≥2 of five tests within the different cognitive domains of memory, executive functioning, and information processing speed. Logistic regression analysis was performed.
RESULTS: POCD was observed in 44 (17.7%) of 248 included patients. Age >75, preoperative Mini-Mental State Examination (MMSE) score ≤26 and major surgery were independent significant predictors for POCD. In multivariate logistic regression analysis, no significant associations were shown between the early surgery-induced inflammatory response and either POCD or decline within the different cognitive domains.
CONCLUSIONS: This study shows that one out of six older patients with cancer developed POCD within 3 months after surgery. The early surgery-induced inflammatory response was neither associated with POCD, nor with decline in the separate cognitive domains. Further research is necessary for better understanding of the complex etiology of POCD.
The present invention relates to a rifampicin membrane and a preparation method thereof. The rifampicin membrane is mainly suitable for treatment of various wounds and diseases about the surface o a human body, burn, scald and a mucous membrane. The rifampicin membrane contains the following main components: rifampicin, polyvinyl alcohol, caine anodyne and a parting agent. Through pretreatment, slurry matching operation, membrane coating operation, drying, packaging operation in a segment mode, and disinfection, the rifampicin membrane is obtained. The rifampicin membrane has the strong functions of bacteriostasis and sterilization. The rifampicin membrane has the advantages of convenient use, easy pasting operation and exchanging operation, more kinds of treated wounds and diseases by the rifampicin membrane, short course of treatment, fewer numbers of medication times, constant medicine release, high cure rate, no toxicity and no side reaction. Through clinical application, the therapeutic effect of the rifampicin membrane is obviously better than that of the existing homogeneous therapeutic medicine and the existing homogeneous method which are frequently used.
PROBLEM TO BE SOLVED: To provide a test reservation method for deciding a daily test schedule that is optimized as a test necessary for the diagnoses of patients in accordance with the characteristic and condition of disease of each patient by scheduling the designated tests according to the limit of very test and fixing a concrete date for every scheduled test. SOLUTION: This system is installed at an ambulatory test reservation center 2 and a test place 4. A reservation server 10 consists of every test reservation daily schedule data base 14 included in a storage, an inhibition processor 16 serving as a processing mechanism, an individual equipment management device 20 and a priority deciding device 24. The processor 16 includes an inhibition item table 18 for every check, and the device 24 includes a test priority table 26. In such a constitution, the requests can be automatically processed for plural physiological and radiation tests. Thus, a daily test schedule can be decided in time series according to the diagnosis of each patient and an effective composite test reservation system is attained.
The endothelial glycocalyx, a gel-like layer that lines the luminal surface of blood vessels, is composed of proteoglycans, glycoproteins, and glycosaminoglycans. The endothelial glycocalyx plays an essential role in vascular homeostasis, and its degradation in trauma and sepsis can lead to microvascular dysfunction and organ injury. While there are no proven therapies for preventing or treating endothelial glycocalyx degradation, some initial literature suggests that plasma may have a therapeutic role in trauma and sepsis patients. Overall, the literature suggesting the use of plasma as a therapy for endothelial glycocalyx degradation is non-clinical basic science or exploratory. Plasma is an established therapy in the resuscitation of patients with hemorrhage for restoration of coagulation factors. However, plasma also contains other bioactive components, including sphingosine-1 phosphate, antithrombin, and adiponectin, which may protect and restore the endothelial glycocalyx, thereby helping to maintain or restore vascular homeostasis. This narrative review begins by describing the endothelial glycocalyx in health and disease: we discuss the overlapping disease mechanisms in trauma and sepsis that lead to its damage and introduce plasma transfusion as a potential therapy for prevention and treatment of endothelial glycocalyx degradation. Second, we review the literature on plasma as an exploratory therapy for endothelial glycocalyx degradation in trauma and sepsis. Third, we discuss the safety of plasma transfusion by reviewing the adverse events associated with plasma and other blood product transfusions, and we examine modern transfusion precautions that have enhanced the safety of plasma transfusion. We conclude that the literature proposes that plasma may have the potential to prevent and treat endothelial glycocalyx degradation in trauma and sepsis, indicating the need for further research.
Stomach and intestine diseases in the digestive system frequently occur in summer and autumn, and are caused by eating untidy food with shigella dysenteriae. The stomach and intestine diseases are divided into gastroenteritis and deficiency-cold in spleen and stomach according to pathogenic factors. Symptoms of the stomach and intestine diseases comprise uncomfortableness throughout the whole body, watery stool, dyspepsia, paroxysmal stomachache for several times a day, not high fever, pressing pain in the right lower quadrant, and much stool mixed with mucus and rancid flavor. The invention discloses an oral/applying liquid used for treating the stomach and intestine diseases and skin pain. The liquid is prepared by melting 2000 g of fresh quick lime block obtained immediately after a kiln is opened, 3000 g of plain boiled water having a temperature of 85-100 DEG C and a bottle of sesame oil by utilization of a processing technology, and is for oral administration or external local application. Based on clinical pathogenic-factor summary of a plurality of patients and repeated practice, the liquid provided by the invention has strong sterilization functions, disinfection functions, anti-inflammation functions, and skin-care functions. The liquid has unique curative effects for the human stomach and intestine diseases and significant curative effects on the human skin pain, and makes groundbreaking accomplishment for skin protection. The liquid is free of toxic and side effects, and is an innovative technology for treating the stomach and intestine diseases and the skin pain.
Our project is designed to help families and children with mild or moderate symptoms early, before problems become worse and more difficult to treat.

The Strongest Families Program is a distance parenting program that was developed at the Centre for Research in Family Health at the IWK Health Centre in Halifax, Nova Scotia. Most families are able to manage these problems if they are given the skills to do so. The Strongest Families "Parenting the Active Child" Distance Program is done over the telephone; families do not have to travel to a centre to receive help. This program includes a handbook, videos and weekly phone calls between the parent and non-professional'coach'. The coach provides support to families, answer questions and guide parents as they learn the skills. Strongest Families has helped hundreds of families in Nova Scotia.
299,522. Leonard, V. July 29, 1927. Antiseptics; lotions; medicines for internal use. -An effective bactericidal solution of normal hexyl resorcinol, for sterilizing living tissue surfaces or objects such as surgical and dental instruments or false teeth, is prepared by dissolving the hexyl resorcinol in glycerol and adding water to obtain a clear solution having a very low surface tension. There is an optimum composition of glycerol and water at which the surface tension reaches a minimum value and the germicidal power reaches a maximum. Further addition of water does not precipitate the hexyl resorcinol and only raises the surface tension relatively slightly. As an example, one part of hexyl resorcinol is dissolved in 300 parts by weight of glycerol .and 700 parts of water are added. The clear solution obtained has a surface tension of 3'7 dynes per centimetre. Reference is made in the Specification to the known use of a solution of hexyl resorcinol in olive oil for internal administration. Specifications 9726/94 and 15931/08 are referred to. The Provisional Specification describes the application of the process to such of the higher phenols (such as hexyl resorcinol and its homologues) as are soluble in glycerol, or to mixtures of these higher phenols.
Approximately one-third of patients with myeloid disorders like myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) exhibit inflammatory and autoimmune disorders (IADs). These IADs often include atypical and incomplete forms of common autoimmune conditions, and exhibit resistance to conventional immunosuppressive therapies. There is growing interest in molecular relationships between IADs and MDS/CMML to find potential targeted therapies. Recently, patients with somatic mutations in the UBA1 gene were identified as having VEXAS syndrome. Herein, we present a concise case-series illustrating concurrent elderly-onset inflammatory manifestations and myeloid disorders (MDS, CMML, and idiopathic cytopenia of undetermined significance). These patients manifested inflammatory or autoimmune symptoms, including erythema nodosum, Raynaud's phenomenon, Sjogren syndrome, and refractory pruritus, having onset after 60-years of age. The inflammatory manifestations were largely refractory to traditional immunosuppressive regimens. Remarkably, treatment with a JAK-1 inhibitor, upadacitinib, in two cases yielded marked resolution of inflammatory symptoms, facilitating the gradual tapering of corticosteroids, improvement of hemoglobin levels, and reduction in serum C-reactive protein levels. Upon loss of response to upadacitinib, JAK-2 inhibitor ruxolitinib provided clinical benefit in one of the cases, facilitating further tapering of glucocorticoids. This arena warrants further exploration through prospective studies of larger cohorts to delineate optimal management strategies.
The invention comprises 3-isoreserpic acid of the formula <FORM:0823707/IV (b)/1> together with esters thereof wherein the carboxyl group is esterified and the hydroxyl group is free or esterified and also the corresponding salts with acids or bases.  The compounds are prepared by (a) epimerization of reserpic acid or an ester thereof or salt of such acid or ester with a "Lewis acid," e.g. carboxylic acids, aromatic sulphonic acids, BF3, or hydrohalic acids; or (b) treatment of tetradehydroreserpic acid or ester thereof or salt of such acid or ester with sodium borohydride.  Subsequent hydrolytic or esterification processes may be performed.  Specified esterifying acids are acetic, phenylacetic, benzoic, furane-2-carboxylic acid and particularly 3 : 4 : 5-trimethoxybenzoic acid.  Examples detail the preparation of methyl O-p-toluene-sulphonyl- and O-acetyl-3-isoreserpates, methyl 3-isoreserpate, its nitrate, methyl 3-isoreserpine and its nitrate. Specification 744,290 is referred to.ALSO:3-Isoreserpic acid, its esters and their salts with acids and bases are incorporated into hydrophilic ointments to form sun screen compositions.  Also by conversion to quaternary compounds with reactive esters of higher alcohols, e.g. lauryl alcohol, the compounds can be used as disinfectants, and are active against Staphylococcus aureus. Specification 744,290, [Group IV (b)], is referred to.
The invention comprises dithiocarbamates of formula R-S-C(=S)NHR1 wherein R is a carbocyclic aryl group, R1 is an acyclic or alicyclic aliphatic hydrocarbon group, R and R1 being optionally substituted. The compounds are prepared by reacting an isothiocyanate R1NCS with a mercaptan RSH. In examples, where R1 is methyl, R is phenyl, o- or p-chlorophenyl, 2, 4, 5-trichlorophenyl, pentachlorophenyl, o- or p-tolyl, xylyl, p-t-butylphenyl or naphthyl; the compound wherein R1 is 2-cyanoallyl and R is phenyl is also specified. Other compounds within the general formula are also listed.ALSO:Coccidiostatic animal feeds comprise an inert edible carrier and at least one dithiocarbamate of formula R-S-C(=S)NHR1, wherein R is a carbocyclic aryl group, R1 is an acyclic or alicyclic aliphatic hydrocarbon group, R and R1 being optionally substituted.  Other coccidiostats such as sulphaquinoxaline, 4,41-dinitrocarbanilide/2-hydroxy-4,6-dimethylpyrimidine complex, 3,31-dinitrodiphenyldisulphide, arsonilic acid, 3-amino-4-hydroxyphenylarsonic acid or 5-nitrofurfural semicarbazone may be present, vitamins, growth promoting agents and antibiotics are also mentioned and a feed supplement containing many such additives is specified.  The active compound (and optionally a surface-active ingredient) may be added to the drinking water of animals. Antimicrobial compositions comprising said dithiocarbamates and a solid or liquid carrier and/or a surface-active agent are described.
Relaxation therapy (3 one-on-one sessions weekly for 3 consecutive weeks) comprised of education about the role of stress in MS biology, and the opportunities stress management provides to handle this issue. Patients were then taught how to apply stress management techniques like Jacobson relaxation skills, Schultz relaxation skills, visualization, etc.
Vaccination coverage against hepatitis A virus (HAV), hepatitis B virus (HBV), and human papillomaviruses (HPV) is insufficient among men who have sex with men (MSM), partly because of their high prevalence of vaccine hesitancy (VH) specific to these vaccines. This study aimed to investigate determinants of specific VH in MSM, focusing on characteristics of their sexual activity, propensity to use prevention tools and medical care, disclosure of sexual orientation to health care professionals (HCPs), and perceived stigmatization. A cross-sectional electronic survey (February - August 2022) collected perceptions of HBV, HAV, and HPV, and of their respective vaccines among 3,730 French MSM and enabled the construction of a specific VH variable. Using agglomerative hierarchical cluster analysis, we constructed a typology of MSM sexual and prevention practices. We identified three MSM clusters (low- (C1, 24%), moderate- (C2, 41%), and high- (C3, 35%) "sexual activity/medical engagement") that showed an increasing gradient in the use of medical prevention with regular medical care and exposure to high-risk sexual practices. A multiple ordinal logistic regression showed that overall specific VH was higher in the C1 cluster and in men who had not informed their physician of their sexual orientation. This typology could usefully help to adapt vaccination communication strategies for MSM prevention program according to patients' profiles. HCPs should be encouraged and trained to ask men about their sexual practices and to provide appropriate vaccination recommendations nonjudgmentally.