anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Hyper lordosis is a condition in which there is an excessive spine curvature in the lower back. Hyper lordosis is a very common symptom. It occurs in high-income, middle-income, and low-income countries and all age groups from children to the elderly population Only a small proportion of people have a well understood pathological cause-eg, a vertebral fracture, malignancy, or infection. People with physically demanding jobs, physical and mental comorbidities, smokers, and obese individuals are at greatest risk of reporting low back pain.Hyper lordosis creates a characteristic C-shaped curve in the lower back, or lumbar region, where the spine curves inward just above the buttocks. It often occurs as a result of poor posture or a lack of exercise. Hyperlordosis can cause muscle tightening and stiffness in the lower back. It can also damage the spine and soft tissues in the lumbar region. Hyperlordosis leads to excessive curvature of the spine in the lower back, causing the abdomen and buttocks to appear more prominent in profile view. People with hyperlordosis may experience mild to severe lower back pain, which may worsen with movement.

Various conservative treatments are used to treat hyperlordosis and low back pain due to hyperlordosis. Most commonly used are the manual therapy techniques that employ William's protocol and hold relax stretching of iliopsoas muscle at lumbar spine. This study will be randomized control trial used to compare the effects of William protocol and hold relax stretching of iliopsoas muscle in subjects with hyperlordosis and low back pain. Subjects meeting the predetermined inclusion and exclusion criteria will be divided into two groups using lottery method. Pre assessment will be done using LUMBAR SPINE QUESTIONNAIRE as subjective measurements and NPRS as objective measurements. Subjects in one group will be treated using William's protocol and the other one will be treated with hold relax stretching of iliopsoas muscle. Each subject will receive 08 treatment sessions with 02 treatment sessions per week. Post treatment reading for NPRS and lumbar spine questionnaire will be recorded after every week.Various conservative treatments are used to treat hyperlordosis and low back pain due to hyperlordosis. Most commonly used are the manual therapy techniques that employ William's protocol and hold relax stretching of iliopsoas muscle at lumbar spine. This study will be randomized control trial used to compare the effects of William protocol and hold relax stretching of iliopsoas muscle in subjects with hyperlordosis and low back pain. Subjects meeting the predetermined inclusion and exclusion criteria will be divided into two groups using lottery method. Pre assessment will be done using LUMBAR SPINE QUESTIONNAIRE as subjective measurements and NPRS as objective measurements. Subjects in one group will be treated using William's protocol and the other one will be treated with hold relax stretching of iliopsoas muscle. Each subject will receive 08 treatment sessions with 02 treatment sessions per week. Post treatment reading for NPRS and lumbar spine questionnaire will be recorded after every week.
Women are advised to optimise weight before pregnancy. However, many are either already living with overweight or obesity prior to becoming pregnant, increasing the risks for adverse outcomes. Health care professionals (HCP) are responsible for advising women of risks throughout and following pregnancy. However, midwives often find broaching the conversation around maternal obesity difficult. This study explored the experiences of pregnant women living with obesity in accessing antenatal care. Seventeen women completed a semi-structured interview. Transcripts were analysed thematically. Four themes were developed: 1) antenatal care is inconsistent, 2) additional support is needed, 3) women feel judged about their weight, and 4) weight cycling is highly prevalent. Findings suggest that pregnant women living with obesity often experience weight bias from HCPs, feel judged because of their weight and are left feeling confused and overlooked. Women reported inconsistencies in advice and care offered and acknowledged a lack of continuity of care throughout pregnancy. We call for an urgent need for further multidisciplinary training to address the concerns, experiences and needs of pregnant women living with obesity.
Patients participate in yoga classes comprising postures, deep relaxation, breathing practices, and meditation twice weekly for 75 minutes during weeks 1-6. Patients then practice yoga at home twice weekly for 45 minutes during weeks 7-12.
A single dose of 37-111 Mega-Becquerel (MBq) 68Ga-NOTA Evans Blue will be injected subcutaneously. PET/CT imaging will be performed at 5-30 min post- injection. Visual and quantitative method will be used to assess the PET/CT images.
PURPOSE: A composition containing Sparassis crispa extract with antioxidation is provided to remove DPPH and superoxide anion radical. CONSTITUTION: A composition with antioxidation contains hot water extract of Sparassis crispa as an active ingredient. The Sparassis crispa is a fruit body of Sparassis crispa. The hot water extract is prepared by hot water extraction of the Sparassis crispa fruit body with the water at 95 °C for two and a half hours and decompressing. A pharmaceutical composition with antioxidation contains the hot water extract as an active ingredient. A health food composition or cosmetic composition with antioxidation contains the hot water extract as an active ingredient.
Multiple sclerosis and healthy male subjects participated in the head and neck cooling program. During cooling procedure, the participant performed fatiguing isometric motor task with a head and neck cooling helmet at (18°C next to the head and neck skin).
This study examined the relationship between the systemic inflammation response index (SIRI) and kidney stone occurrence in adults in the United States. It also evaluated its potential as a predictor of kidney stones. A total of 24,833 adult participants were included in the study using cross-sectional data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) database. A history of kidney stones was ascertained through the administration of a questionnaire, and SIRI values (calculated based on neutrophil, monocyte, and lymphocyte counts) were determined for each participant. Logistic regression models were employed to examine the relationship between SIRI and kidney stones while accounting for potential confounding variables such as gender, age, race, lifestyle, and history of chronic disease. Subgroup analyses were also conducted. A significant positive correlation was observed between SIRI and kidney stones. In the unadjusted model, elevated SIRI was significantly and positively associated with an increased risk of kidney stones (OR = 1.17). Analysis of SIRI quartiles demonstrated a gradual increase in the risk ratio of kidney stones with increasing SIRI levels, indicating a clear dose-response relationship. In particular, in the model adjusted for multiple confounding variables, the risk of developing kidney stones in the highest SIRI quartile was increased by 20% compared to the lowest SIRI quartile (OR = 1.20, P = 0.007). There is a significant positive correlation between SIRI and kidney stones. SIRI may predict kidney stone risk and highlight the systemic inflammatory state's substantial contribution to kidney stones' pathogenesis.
The BTL-6000 device, with 12W power and a wavelength of 1,064 nm, will administer laser therapy to the experimental group using the De la Barra et al. protocol. Treatment includes three phases: (Phase 1) Manual scanning 1: 12 W for 42 seconds, delivering 500 J over 100 cm2 per upper trapezius muscle (total 1,000 J). (Phase 2) Point technique: 4 W for 10 seconds per point (10 J per point), totaling 60 J per side (120 J total). (Phase 3) Manual scanning 2: 6 W for 83 seconds, delivering 500 J over 100 cm2 per upper trapezius muscle (total 1,000 J). Following the HILT treatment, we will perform three sets of 30 seconds each of passive bilateral static stretching exercises for the upper trapezius, levator scapulae, and scalene muscles.
PURPOSE: To obtain a hair-dyeing composition free from a trouble regarding the safety of body, capable of producing a one pot-type hair-dyeing agent without lowering hair dyeability, easily dyeable of gray hair and further having no metallic smell, by compounding specific three kinds of compounds. CONSTITUTION: This composition is obtained by using a polyvalent metal salt, ascorbic acid and a ligand (excluding ascorbic acid) together. The ligand is preferably an ascorbic acid (excluding ascorbic acid), an anthrone glycoside, flavone dimer, a flavonoid glycoside, a caffeic acid, a kojic acid, etc. The compounding ratios of a polyvalent metallic salt, an ascorbic acid and a ligand are preferably 0.001-10wt.%, 0.2-10wt.% and 0.001-10wt.% based on the total amount of the hair-dyeing agent, respectively. It is preferable to further add a primary amino acid to this system. The composition does not contain any compound which may cause allergic symptom such as skin rash or may has mutagenicity.
A computing platform configured to receive and process an on-demand real-time patient-specific data analysis order is provided. The computing platform can receive an order, determine the viability of the order, and then perform the desired analysis based on parameters provided within the order. As part of the analysis, the computing platform can mine one or more data sources to collect data relevant to the ordered diagnostic. Once the data is collected, the computing platform can analyze the data according to one or more pre-programmed algorithms. The selection of which algorithms to apply to the data set can be determined by the type of on-demand real-time patient-specific data analysis ordered. The on-demand real-time patient-specific data analysis in some examples can be ordered using an external ordering user interface.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to reflex therapy, neurology and medical rehabilitation, and can be used for treating patients with lumbosacral dorsopathy. After preliminary treatment of skin with antiseptic solution, Alflutop preparation is introduced into the area of points chosen according to reflexotherapy rules and alternated during the course: segmental in lumbosacral region - T3-5, V2Z, 25, 27, V31–34 and distant points - on lower extremities - V39, 40, 57, 60, 62, E36, VB 30, 34, 39, including vascular points RP6.9, F2.3; 6–8 points are used during the procedure: 2–3 segmental and 4–5 remote. Latter are preferably selected on the side of the lesion. In the case of reflex syndromes, selection of points is determined by localization of pathological manifestations, radicular - by a zone of innervation of involved nerve roots, vaso-reflex reactions - a projection of the first lateral line of back in a combination with vascular points RP 6, 9, F 2,3. Alflutope 0.2 ml is injected subcutaneously into each of the points. Therapeutic course includes 10 procedures released every other day.EFFECT: method provides reduced length of treatment, fast regression of clinical symptoms, namely in the form of pronounced regression of pain sensations, increased volume of active motions in lumbar spine, neurovascular disorders, confirmed by special study results, with no negative events and reduced recurrence rate due to introduction of the preparation into the points chosen according to reflexotherapy rules.1 cl, 2 ex
PURPOSE: Flank pain associated with stone disease is typically caused by a stone that obstructs urine flow. However, it is plausible that nonobstructing kidney stones may still cause pain. We performed a multicenter, observational trial to evaluate whether treatment of small nonobstructing calyceal stones improves pain and kidney stone-specific health-related quality of life.
MATERIALS AND METHODS: Patients aged 18 years or older with nonobstructing renal stone(s) up to 10 mm in longest diameter and moderate to severe pain were recruited. All participants completed 3 questionnaires: the Brief Pain Inventory (BPI), the Patient-Reported Outcomes Measurement Information System pain interference form 6a, and the Wisconsin Stone Quality of Life questionnaire. Thereafter, all participants underwent ureteroscopy for renal stone treatment. All 3 questionnaires were repeated at 2, 6 to 8, and at 12 weeks postprocedure. The primary outcomes were change in preoperative to 12-week postoperative mean BPI score and worst BPI pain score.
RESULTS: A total of 43 patients with nonobstructing kidney stones and associated flank pain were recruited. All stones were removed. Preoperatively, BPI scores for mean pain and worst pain were 5.5 and 7.2, respectively which decreased to 1.8 and 2.8 respectively at 12 weeks postoperatively. Wisconsin Stone Quality of Life questionnaire mean score increased from 70.4 to 115.3 at 12 weeks postoperatively. A total of 86% and 69% of patients had at least a 20% and 50% reduction in their mean pain scores, respectively.
CONCLUSIONS: This study determined that patients benefit significantly from the removal of calyceal nonobstructing kidney stones for at least 12 weeks with a reduction in pain and an increase in quality of life. Therefore, surgical removal of these stones in this patient population should be offered as a treatment option.
Participants receive two cycles of HAIC (drugs of oxaliplatin 135 mg/m2 over 3 hours; calcium folinic acid 400 mg/m2 or levofolinic acid 200 mg/m2 over 1. 5 hours, 5-FU 400 mg/m2 over 2 hours, and 5-FU 2400 mg/m2 over 46 hours,every 4 weeks), then evaluate the response of tumor, and those who achieve complete response (CR ) will receive surgical resection or follow-up, while other patients continue to receive two cycles of combination therapy, i.e. HAIC combined with targeted drug (levatinib 8mg/day) and immunotherapy (PD-1 antibody, dose and frequency according to instructions). After four cycles, a second efficacy assessment will be performed, and patients who achieve CR will undergo surgical resection or follow-up observation, and the other patients will be evaluated for the possibility of surgical resection or the subsequent treatment.
Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genetic basis of prostate cancer in African men has been understudied. We used genomic data from 3,963 cases and 3,509 controls from Ghana, Nigeria, Senegal, South Africa and Uganda to infer ancestry-specific genetic architectures and fine-map disease associations. Fifteen independent associations at 8q24.21, 6q22.1 and 11q13.3 reached genome-wide significance, including four new associations. Intriguingly, multiple lead associations are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of prostate cancer differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African prostate cancer associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.
A system may provide hardware acceleration for corrective blockchain-based record entry. Blockchain management circuitry (BMC) may receive a correction to a record entry. The BMC may access a consensus operating procedure. The BMC may apply the consensus operating procedure to the record entry to determine a corrective indicator. After completing the consensus operating procedure, the BMC may append a corrective block generated based on the record entry and corrective indicator to the blockchain. Accordingly, the system may ensure that corrective blocks added to the blockchain were generated in compliance with the consensus operating procedure.
Iatrogenic acute limb ischaemia (ALI) in neonates is a rare but severe event with potentially deleterious outcomes. In the neonatal intensive care unit, this risk is increased due to the high rate of catheterisation procedures. ALI management includes pharmacological and non-pharmacological interventions, but no commonly accepted clinical guidelines are available. In the present case, a peripheral catheter was erroneously placed in the left brachial artery of a term infant, causing blockage and ischaemia in the limb. The catheter was immediately removed, the affected limb was elevated and warm compresses were applied to the contralateral limb. The patient was treated with fresh frozen plasma, heparin, iloprost and topical nitroglycerin. Three nerve block procedures were also performed. At 6-8 days of age, significant improvement was observed. The patient was discharged at 17 days of age with near-complete resolution, whereas complete resolution was observed at postdischarge follow-up.
An iron-polysaccharide complex is made by heating a polysaccharide with hydrogen peroxide, and at a pH above 8, with a non-toxic ferric compound and bringing the resulting complex into colloidal solution. The polysaccharide may have been heated under alkaline, neutral or weakly acid conditions with the hydrogen peroxide, prior to effecting complex formation.  The product may be dried, and formed into solution with a chelating hydroxyacid. Specified polysaccharides are starch, dextran, levan, insulin, mannan and pullulan; specified ferric compounds are the nitrate, chloride, acetate or ferric ammonium chloride or a ferric oxy-salt.  The chelating acid may be citric, tartaric, lactic, glycolic or salicylic acid.ALSO:An iron-polysaccharide complex which has been prepared by reacting, at a pH above 8, a polysaccharide which has been treated with hydrogen peroxide and a non-toxic ferric compound and which has been brought into colloidal suspension, may be used in the preparation of an injectable preparation.  In examples, the complex is brought into solution using secondary sodium citrate as a chelating agent, the pH is adjusted to 6.3, the solution rendered isotonic e.g. with NaCl, and then sterilized at 105 DEG C. for 1/2 -hour, yielding a solution containing 100 mg Fe/ml. Specified polysaccharides are starch, dextran, mannan, inulin, pullulan and levan.  Other chelating agents are citric, lactic, tartaric, glycolic or salicylic acids.
Preparations for the care and hygiene of the mouth, e.g dentifrices, mouth washes, tooth powders and dental floss, lozenges, tablets and chewing-gum comprises an organopolysiloxane and a higher aliphatic acyl amide of an aminocarboxylic acid compound of the type described and claimed in the main inventions of the parent Specifications. Dimethyl polysiloxanes (methyl silicones) having the structure <FORM:0789851/VI/1> where n is from 23 to 211, are particularly effective, although n may be 1 and preferably from 14 up to 2000. Dimethyl polysiloxanes having viscosities of up to 100,000 centistokes at 25 DEG  C. may be used, e.g. Dow Corning 200 fluids having viscosities of 10, 20, 50, 100, 200, 350, 500 and 1000 centistokes at 25 DEG  C. Organopolysiloxane fluids having an aromatic group such as phenyl, tolyl or benzyl, and an aliphatic group such as methyl, attached to the silicon atom may also be used. An example is the methyl phenyl polysiloxanes which are copolymers having viscosities of 10 to 1000 centistokes at 25 DEG  C.  The organopolysiloxane and the amide are used in quantities of at least 0.05 per cent and preferably 0.1 to 10 per cent by weight of the composition.  Dental creams contain 0.5 to 5 per cent by weight of the amide and from 0.1 to 2.0 per cent by weight of the organopolysiloxane.  The organopolysiloxane is used in amounts insufficient substantially to affect adversely the foaming power during use.  Examples relate to (a) a dental cream containing sodium N. lauroyl sarcoside, a methyl silicone fluid of 350 cs. viscosity, calcium carbonate, dicalcium phosphate dihydrate glycerin and water; (b) a similar cream containing a copolymer of methyl siloxane and phenyl siloxane; (c) a dental powder containing sodium N-lauryl sarcoside, disodium acid pyrophosphate, methyl silicone fluid (350 cs. viscosity), saccharin, flavour and dicalcium phosphate dihydrate; (d) mouthwash containing sodium N-lauroylsarcoside, methyl phenyl silicone (35-60 cs.), ethyl alcohol, flavour, saccharin and water; (e) liquid dentifrice containing potassium lauroyl sarcoside, methyl phenyl silicone (35-60 cs.), ethyl alcohol, flavour, saccharin and water; (f) chewing gum containing sodium lauroyl sarcoside, methyl silicone fluid (1000 cs.) gum base (chicle), sucrose, corn syrup and flavour.  Specification 686,429 also is referred to.
OBJECTIVE: To evaluate the frequency of cachexia and its associated factors using the Asian Working Group for Cachexia (AWGC) criteria in elderly patients with diabetes and chronic diseases.
METHODS: The subjects were diabetic outpatients of ≥65 years of age who were managed at Ise Red Cross Hospital. Patients with chronic disease (chronic heart failure, cancer, or chronic renal failure). Cachexia was evaluated based on the AWGC criteria and was defined as a body mass index (BMI) <21 kg/m2 and one or more of the following: anorexia, elevated C-reactive protein, and decreased grip strength. A logistic regression analysis was used to identify cachexia-related factors, with cachexia as the dependent variable, and various variables (basic attributes, blood glucose-related parameters, diabetic complications, comorbidities, and treatment) as explanatory variables.
RESULTS: Two hundred forty-two patients (male, n=164; female, n=78) were included in the study. Forty patients (16.5%) had cachexia. A logistic analysis revealed that age (odds ratio (OR), 1.16; P<0.001), type 1 diabetes (OR, 15.25; P=0.002), diabetic retinopathy (OR, 5.72; P=0.001), and physical frailty (OR, 7.06; P<0.001) were associated with cachexia.
CONCLUSION: Elderly diabetics with chronic diseases were more likely to have cachexia. According to the AWGC criteria, the frequency of cachexia was 16.5% in elderly patients with diabetes and chronic diseases. Additionally, type 1 diabetes, diabetic retinopathy, age, and physical frailty were identified as factors associated with cachexia. In elderly diabetes patients with chronic diseases, it is therefore important to raise awareness regarding cachexia when these related factors are diagnosed.
After a wash out of 15 minutes with conventional oxygen therapy, CPAP with a Positive End -Expiratory Pressure of 7 cmH2O will be introduced, with an inspiratory oxygen fraction required for an oxygen saturation of 94%, during 30 minutes. The collection of EAdi min/max will be done every minutes over 30min as well as the collection of HR, Respiratory rate (RR), SpO2, while TCPCO2, distress respiratory score and pain score will be taken at M0 and M30.