anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The effect of anti-inflammatory substances on the constriction of the fetal ductus arteriosus is well documented, but the anti-inflammatory property of polyphenols and their effect on the metabolism of prostaglandins are not established. Evidence indicates that foods rich in polyphenols consumed from the third trimester of pregnancy may interfere with anatomical and functional activity of the fetal heart, presumably by the action similar to anti-inflammatory drugs nonsteroidal, causing inhibitory effect on prostaglandin synthesis. Objective: The objective of this study was to evaluate the effect of polyphenol supplementation on plasma levels of prostaglandin E2 in women of childbearing age use of hormonal contraceptives. As secondary endpoints were also evaluated other markers of inflammation and oxidative stress. The selected women were randomized to receive capsules polyphenol at a concentration of 3000 mg / day or placebo capsules to be consumed daily for fifteen days. Was applied dietary recall to assess intake of polyphenols, measured height and weight and carried blood samples for prostaglandin analysis E2 (PGE2), high sensitive C-reactive protein, and urine for analysis of total polyphenols and F2 isoprostane (8 iso-PGF2a). Statistical analysis: The results will be expressed through absolute and relative frequencies and mean ± standard deviation (SD) or median and interquartile range. For analysis, Pearson correlation is used. To compare the means will be used Student's t test. The level of significance is 5%. Considering a 90% power, with absolute error margin of 5% in the present study, 13 patients were needed in each group.
Each lighting condition will last for three weeks (Weeks 2-4 or 5-7). The order of conditions will be randomized. Sleep data will be collected only on the last 7 days of each condition using actigraphy. Light spectrum and intensity will be tracked continuously throughout the waking hours (wearable light tracker). Moreover, caregivers will complete two questionnaires (CSDD and CMAI) every seven days to assess the short and long-term effects of each condition on mood and agitation of older adult participants.
Low-load resistance training promotes muscle strength and hypertrophic adaptations when combined with blood flow restriction (BFR). However, the effect of BFR on muscle endurance remains unclear. The aim of this study was to clarify the effects of BFR on muscle performance and adaptation, with special reference to local muscle endurance. In experiment 1, eight healthy men performed unilateral elbow flexion exercise to failure at 30% of one-repetition maximum with BFR (at 40% of estimated arterial occlusion pressure) and free blood flow (FBF). During the exercise, muscle activity and tissue oxygenation were measured from the biceps brachii. In experiment 2, another eight healthy men completed 6 weeks of elbow flexion training with BFR and FBF. The number of repetitions to failure at submaximal load (Rmax), the estimated time for peak torque output to decay by 50% during repetitive maximum voluntary contractions (half-time), one-repetition maximum, isometric strength and muscle thickness of elbow flexors were measured pre- and post-training. Blood flow restriction resulted in fewer repetitions and lower muscle tissue oxygenation at the end of exercise than FBF, while the muscle activity increased similarly to repetition failure. Blood flow restriction also resulted in a smaller post-training Rmax, which was strongly correlated with the total exercise volume over the 6 week period. Despite the smaller exercise volume, BFR resulted in similar improvements in half-time, muscle strength and thickness compared with FBF. These results suggest that the application of BFR can attenuate muscle endurance adaptations to low-load resistance training by decreasing the number of repetitions during exercise, both acutely and chronically.
Clinician and patient set up N-of-1 trial 4-12 weeks in length to compare two treatments for chronic pain. Patient uses Trialist smartphone app to monitor pain and associated side effects daily throughout length of N-of-1 trial. After trial ends, the patient reviews graphical displays of N-of-1 trial results with clinician.
BACKGROUND: With the advancement of cancer treatment, appropriate treatment for musculoskeletal problems is becoming more important as it extends the patient's lifespan and improves the quality of life. In surgical treatment for metastatic spine tumors (MST), various efforts are being considered to obtain a good prognosis. The purposes of this study are to analyze prognostic factors for postoperative ambulation and perioperative complications in patients surgically treated for MST with neurologic symptoms.
METHODS: Seventy five cases of patients who underwent surgery for MST with neurologic symptoms were enrolled between December 2016 and January 2023. Postoperative ambulatory function and medical complications were assessed for each patient in this study. The endpoint of ambulatory function was defined as the best function among entire periods of follow-up outpatient visits. We defined the improvement of ambulatory function as improvement in Eastern Cooperative Oncology Group (ECOG) scale. For complications, we applied complication classification system for orthopaedic surgery. Perioperative complications were defined as those requiring changes of treatment compared with routine postoperative treatment during patient's admission. Confirmed complications included expire, delirium, urinary tract infection (UTI), pneumonia, sepsis, bacteremia, acute kidney injury (AKI), chylothorax. Prognostic factors were collected and analyzed for relationship by logistic regression.
RESULTS: Of the 75 cases, postoperatively 42 (56%) cases of patients were improved in Nurick grade, 36 (48%) cases of patients in ECOG performance. And 21 (28%) cases of patients were treated in intensive care unit (ICU) and 15 (20%) cases of patients suffered from major perioperative complications. Regression analysis showed that clinical factors such as ECOG, psoas muscle index (PMI) and prognostic nutritional index (PNI) were related to the improvement of ambulatory function and incidence of perioperative complications. On multivariate analysis, improvement of ambulatory function was associated with PMI (p = 0.014) and incidence of perioperative complications was associated with PNI (p = 0.045).
CONCLUSIONS: Preoperative nutritional status and sarcopenia are related factors in the outcome of surgical treatment for MST, and preoperative efforts to improve these may be a way to obtain better clinical results.
The present invention relates to injections for ocular tissues containing a conjugate covalently bonded a drug to PEG. When the drug--PEG conjugate is injected into the ocular tissues, the drug can be retained in the ocular tissues such as an iris, a ciliary body, a vitreous body, a retina and an optic nerve for a long period. Accordingly, the injections for ocular tissues of the present invention make it possible to treat or prevent diseases in various ocular tissues over a long period by a single administration. PEG can be any of straight-chain, stellate and branched. In the case of straight--chain PEG, since the drugs are generally bonded using hydroxyl groups at its both ends, a binding ratio of the drug to PEG is 1:1 or 2:1. Since stellate and branched PEGs have plural hydroxyl groups, plural covalent bond of drugs to PEG can be formed.
Participants will receive DARA SC (daratumumab 1800 milligram \[mg\] with Recombinant Human Hyaluronidase \[rHuPH20\] 30,000 units \[U\] that is 2000 U/milliliter \[U/mL\]) subcutaneous (SC) injection once weekly for the first 8 weeks in Cycles 1 and 2 (Days 1, 8, 15, and 22 of each week), every 2 weeks in Cycles 3 to 6 (Days 1 and 15) for the following 16 weeks and then every 4 weeks (from Cycle 7 \[Day 1\]) in subsequent cycles until disease progression, unacceptable toxicity, or any other reason for discontinuation. Each cycle is 28 days in duration.
The paclitaxel drug-coated balloon (DCB) is an emerging device in percutaneous coronary intervention (PCI); it allows a rapid local release of an anti-restenotic drug without the use of a durable polymer or metal scaffold. The DCB has been proven to be effective with paclitaxel in preclinical trials and in clinical practice for the treatment of coronary lesions such as in-stent restenosis (ISR), de novo and bifurcation lesions. Optical coherence tomography (OCT) is an intravascular imaging modality that has higher resolution than intravascular ultrasound. Excellent contrast among lumen, vessel, and stent in OCT images allows accurate measurement of lumen and lesion. However, only a few studies have investigated the effect of DCB on the intimal lumen in the acute phase and during the follow-up using optical coherence tomography (OCT). In this study, the investigators preformed OCT before and after DCB treatment, as well as at 6 months of follow-up, to assess the tissue characterization.

Demographic, angiographic, and procedural data were collected. Participants were followed up with coronary angiography and OCT for at least 6-9 months, combined with OCT to analyze qualitative analysis of changes in plaque characterization, and late lumen loss. The participants were followed up for long-term clinical events (including cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization).
BACKGROUND: Vitamin E-doped cross-linked polyethylene (VEPE) has encouraged the use of larger heads in thinner liners in total hip arthroplasty (THA). However, there are concerns about wear and mechanical failure of the thin liner, especially when metal heads are used. The aim of this randomized controlled trial was to investigate if the use of a large metal head in thin VEPE liner would increase polyethylene wear compared with a standard 32-mm metal head and to compare periacetabular radiolucencies and patient-reported outcomes in THA.
METHODS: There were 96 candidates for uncemented THA who were randomly allocated to either the largest possible metal head (36 to 44 mm) that could be fitted in the thinnest available VEPE liner (intervention group) or a standard 32-mm metal head (control group). The primary outcome was proximal head penetration, measured with a model-based radiostereometric analysis. Secondary outcomes were periacetabular radiolucencies and patient-reported outcomes. The midterm results of the trial at 5 years are presented.
RESULTS: The median total proximal head penetration (interquartile range) was -0.04 mm (-0.12 to 0.02) in the intervention group and -0.03 mm (-0.14 to 0.05) in the control group (P = .691). The rates of periacetabular radiolucencies were 1 of 44 and 4 of 42 (P = .197), respectively. Patient-reported hip function and health-related quality of life did not differ between the groups, but participants in the intervention group reported a higher level of activity (median University of California Level of Activity score 7 versus 6, P = .020). There were 5 revisions caused by dislocations (2), periprosthetic fracture (1), stem subsidence (1), or iliopsoas impingement (1).
CONCLUSIONS: Large metal heads in thin VEPE liners did not increase liner wear and were not associated with liner failure 5 years after THA.
Participants will register in ePain for an individual account. Then they will finish the the pre-test questionnaire. They will be randomized to either the intervention group or control group. ePain will be accessed by the participants in the intervention group. The control group will remain their regular activities. The participants in both groups will need to complete the pre-test (Week 1), process evaluation (Week 3), post-assessment (Week 6) and follow-up assessment (Week 12). Same questionnaire will be used in the assessments. Demographic data will be collected in Week 1. At Week 1, 3, 6 and 12, pain situation and pain self-efficacy will be collected. Data of negative emotions and quality of life will be collected at Week 1, 6 and 12. The control group will undergo the same assessment as the intervention group.
The present invention relates to a medicinal composition having anti-oxidative and anti-inflammatory effects. More particularly, the present invention relates to anti-oxidative and anti-inflammatory composition extract from a mixture of licorice, Platycodonis Radix, Platycodon grandiflorum, Aralia continentalis Kitagawa, peppermint, Saposhnikovia divaricata Schischkin, Cicadidae Periostracum, or the like, and a pharmaceutical composition comprising the same. The present invention provides an anti-oxidative and anti-inflammatory composition obtained by extraction of a mixture of licorice, Ostericum Koreanum, Platycodonis Radix, Aralia continentalis Kitagawa, peppermint, Saposhnikovia divaricata Schischkin, Cicadidae Periostracum, Bupleurum falcatum, ginseng, Cnidium officinale Makino, Poria cocos, Anthriscus sylvestris, Poncirus trifoliata, Hetaeria sikokiana, Schizonepeta tenuifolia, Betula platyphylla var. japonica and Dictamnus dasycarpus. In addition, the present invention provides an anti-oxidative and anti-inflammatory composition obtained by extraction of a mixture of 100 parts by weight of licorice, 80-120 parts by weight of Ostericum Koreanum, 80-120 parts by weight of Platycodonis Radix, 80-120 parts by weight of Aralia continentalis Kitagawa, 80-120 parts by weight of peppermint, 80-120 parts by weight of Saposhnikovia divaricata Schischkin, 80-120 parts by weight of Cicadidae Periostracum, 80-120 parts by weight of Bupleurum falcatum, 80-120 parts by weight of ginseng, 80-120 parts by weight of Cnidium officinale Makino, 80-120 parts by weight of Poria cocos, 80-120 parts by weight of Anthriscus sylvestris, 80-120 parts by weight of Poncirus trifoliata, 80-120 parts by weight of Hetaeria sikokiana, 80-120 parts by weight of Schizonepeta tenuifolia, 180-240 parts by weight of Betula platyphylla var. japonica and 180-240 parts by weight of Dictamnus dasycarpus. The present invention also provides a pharmaceutical composition comprising the anti-oxidative and anti-inflammatory composition.
Device consists of a wall, made at least partly of a material which is permeable to the external fluid, which defines a compartment. This contains (1) a compsn. contg. active ingredient (I) and an osmopolymer (II) and (2) a compsn. of (II) only. - The wall has an opening which establishes contact between the exterior and (1). Pref. both compsns. inside the compartment are formulated as layers and both imbibe fluids which permeate in through the walls.
BACKGROUND: The Chinese government launched the Essential Public Health Service (EPHS) program nationwide in 2009. However, prior studies have not provided clear and integrated evidence on whether the EPHS program improves health outcomes and prevents financial risks among individuals. Because hypertension is the chronic disease with the highest prevalence, this study evaluated the impact of the EPHS program among hypertensive patients to provide evidence for the progress of the program.
METHODS: A cohort of hypertensive patients was identified from the 2011-2018 China Health and Retirement Longitudinal Study (CHARLS). The outcomes assessed included hospitalization expenditure, outpatient expenditure and cardiovascular disease (heart attack and stroke). The key independent variable was whether an individual received EPHS-covered blood pressure measurements in 2013-2015. Based on the International Health Partnership+ (IHP+) common monitoring and evaluation (M&E) framework, a difference-in-differences (DID) method with propensity score matching (PSM) was used to examine the impact of the EPHS program on hypertensive patients.
RESULTS: The results showed that among hypertensive patients covered by the EPHS program, outpatient total costs/OOP costs were reduced by 29.8% and 30.8%, respectively, and hospitalization total costs/OOP costs were reduced by 34.9% and 35.6%, respectively. The EPHS program reduced the probability of heart attack and stroke among hypertensive patients by 3.5% and 2.7%, respectively. Mechanistic tests showed that the EPHS program improved health outcomes by reducing alcohol consumption and increasing physical activity, thereby further reducing health expenditure among hypertensive patients. The impacts of the EPHS program on hypertensive patients varied by age, educational attainment, residential region, and alcohol consumption status.
CONCLUSION: The EPHS program in China significantly improved health outcomes and prevented financial risks for hypertensive patients. This evidence provides a valuable reference for low- and middle-income countries with their essential public health service programs.
The present invention relates to the utilization of five groups of essential oil compositions, formed by mixing pure natural plant essential oils, with characteristics of five elements theory and with excellent infiltration for absorption and which may cooperate with the human body coordination, circulation system to adjust the anion-cation balance of whole body. The essential oil composition with excellent infiltration, absorption characteristics used for gently scraping is related to use natural essential oils to cooperate with the five elements theory of traditional Chinese medicine to prepare five groups of essential oil mixtures of fire, wood, water, metal, and earth, and by utilizing the characteristic of excellent infiltration absorption of the essential oil and five elements theory to maintain the balance of five elements of human body and restore the health of human body. The gently spine scraping method of this invention is related to the utilization of the tradition Chinese medicine theory. The Ren meridian distributes in the middle of chest and abdomen and reaches up to the chin which is the location all Yin meridians join, therefore it is called the sea of Yin meridians and has the effect of adjusting the qi of all Yin meridians of the whole body. The Du meridian circulates in the middle of the waist and back and reaches up to head which is the location all Yang meridians join, therefore it is called the sea of Yang meridians and has the effect of adjusting the qi of all Yang meridians of the whole body. By the gentle scrape of the Ren and Du meridians, the balance of five elements can be maintained and the health of human body can be restored.
Intravenous studies in rats with albuterol sulfate have demonstrated that albuterol crosses the blood-brain barrier and reaches brain concentrations amounting to approximately 5.0% of the plasma concentrations. In structures outside the brain barrier (pineal and pituitary glands), albuterol concentrations were found to be 100 times those in the whole brain.

Studies in laboratory animals (minipigs, rodents, and dogs) have demonstrated the occurrence of cardiac arrhythmias and sudden death (with histologic evidence of myocardial necrosis) when beta-agonists and methylxanthines are administered concurrently. The clinical significance of these findings is unknown.

Clinical Trials

In controlled clinical trials in adults, most patients exhibited an onset of improvement in pulmonary function within 5 minutes as determined by FEV1. FEV1 measurements also showed that the maximum average improvement in pulmonary function usually occurred at approximately 1 hour following inhalation of 2.5 mg of albuterol by compressor-nebulizer and remained close to peak for 2 hours. Clinically significant improvement in pulmonary function (defined as maintenance of a 15% or more increase in FEV1 over baseline values) continued for 3 to 4 hours in most patients, with some patients continuing up to 6 hours.

Published reports of trials in asthmatic children aged 3 years or older have demonstrated significant improvement in either FEV1 or PEFR within 2 to 20 minutes following single doses of albuterol inhalation solution. An increase of 15% or more in baseline FEV1 has been observed in children aged 5 to 11 years up to 6 hours after treatment with doses of 0.10 mg/kg or higher of albuterol inhalation solution. Single doses of 3, 4, or 10 mg resulted in improvement in baseline PEFR that was comparable in extent and duration to a 2-mg dose, but doses above 3 mg were associated with heart rate increases of more than 10%.
This group is used as a control group. They keep training their sports discipline but don't join the 12-week PFM training protocol.
Polyethylene glycol + ascorbic acid solution. Used 2 l before colonoscopy. Bowel preparation interval: QD/BID or one day.
Patients with end-stage renal disease (ESRD) and hemodialysis have a very high risk for cardiovascular events and a very high cardiovascular mortality. Uncontrolled treatment resistant hypertension (TRH) is an important factor driving this very high cardiovascular event risk. Clinical and experimental studies have clearly shown that sympathetic nerve activity is increased in patients with chronic kidney disease (CKD) and substantially aggravates the progression of CKD. In patients with ESRD and chronic hemodialysis bilateral nephrectomy reduced increased sympathetic nerve activity. Interestingly, kidney transplantation did not normalize peripheral sympathetic activity unless the native kidneys were removed. Thus, afferent sensory nerve signaling from the diseased kidneys to the central nervous system is an important pathophysiologic mechanism in CKD leading to sympathetic overactivity and hypertension. Clinical studies have demonstrated that invasive, catheter-based renal denervation (RDN) decreases the sympathetic nerve activity in the whole body and in particular in the kidneys
Vehicle cognitive data is collected using multiple devices. A user interacts with various pieces of technology to perform numerous tasks and activities. Reactions can be observed and cognitive states inferred from reactions to the tasks and activities. A first computing device within a vehicle obtains cognitive state data which is collected on an occupant of the vehicle from multiple sources, wherein the multiple sources include at least two sources of facial image data. At least one face in the facial image data is partially occluded. A second computing device generates analysis of the cognitive state data which is collected from the multiple sources. A third computing device renders an output which is based on the analysis of the cognitive state data. The partial occluding includes a time basis of occluding. The partial occluding includes an image basis of occluding. The cognitive state data from multiple sources is tagged.
Relating to the field of medical technologies, the invention provides a new dosage form of clindamycin phosphate, i.e. preparation and application of temperature sensitive and pH sensitive clindamycin phosphate in-situ gel. The gel is characterized by preparation and application of the gel that is a solution under a nonphysiological state and is gel through phase transition under a physiological state. The temperature sensitive and pH sensitive clindamycin phosphate gel is finally prepared with Poloxamer 407 (F127 for short) and Poloxamer 188 (F68 for short) in a proper ratio. The pH sensitive in situ gel is prepared by Carbopol 980 and Poloxamer F127 in a proper ratio. The gel has viscosity of less than 1100mpa.s under a nonphysiological condition and viscosity of greater than 2500mpa.s under a physiological condition with pH of 4.5. The gel prolongs the detention time of clindamycin phosphate in the vagina and improves the bioavailability and curative effects, thus boasting good application prospects.
1,263,395. Phloroglucic acid derivatives. ORSYMONDE. 29 May, 1970 [29 May, 1969], No. 26146/70. Heading C2C. Novel compounds of formula wherein X is -O- or -NH-, A is C 1-6  alkylene, R is amino or mono- or di-alkylamino or an N-heterocyclic amino group optionally containing a further hetero atom and of 5-7 ring atoms, and acid addition salts thereof, are prepared by reacting phloroglucic acid halide with a compound of formula HXAR optionally with salt formation.  Pharmaceutical compositions having antispasmodic activity being in conventional forms comprise an above novel compound and a carrier therefor.