anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a traditional Chinese medicine for treatment of pharyngitis. The traditional Chinese medicine is prepared from the following crude drugs by weight: 8 parts of Scutellaria baicalensis Georgi root, 6 parts of Belamcanda chinensis, 9 parts of Lonicera japonica, and 6 parts of Gardenia jasminoides Ellis. The inventor believes that pharyngitis is caused by exogenous evil attack to the throat, and attack of exuberant heat in lung and stomach to the throat. Scutellaria baicalensis Georgi root can clear heat, purge pathogenic fire and remove toxin, Belamcanda chinensis can clear heat, remove toxin, dissolve phlegm and relieve sore throat, Lonicera japonica can clear heat and remove toxin, cool and dissipate wind-heat, and Gardenia jasminoides Ellis can reduce fever and cause dieresis, cool blood and eliminate toxin. Combined use of the drugs can achieve the efficacy of dredging lung channel, clearing heat and purging pathogenic fire, removing toxin and relieving sore throat, and can effectively treat pharyngitis. Clinical experiments prove that the traditional Chinese medicine provided by the invention can safely and effectively treat pharyngitis.
NEW MATERIAL:An interleukin 1 active substance. Molecular weight: about 13,000 dalton. pI Value: 6.9+ or -0.1, 6.6+ or -0.1, 5.2+ or -0.1 or 4.7+ or -0.1. pH Stability: stable at 2.3 and 9.0pH. Temperature stability: stable by treatment at 60 deg.C for 15min, stable by repeating treatment of freezing and melting three times and stable by trypsin treatment. USE:To be expected as an antitumor agent. PREPARATION:Human leukemic cell strain (e.g., SSY-1 NCACC No85051502) established by transforming a mononuclear cell obtained from peripheral blood of leukemic patient is cultivated in a medium, active substance IL-1 is accumulated in the culture mixture and the active substance IL-1 is collected from the culture mixture. The human leukemic cell is obtained by separating a mononuclear cell from peripheral blood of acute monocyte leukemic patient by the use of a lymphocyte separated solution by gravity centrifugation method, subjecting the cell to aerated culture in culture solution RPMI-1640 containing 1-15wt% bovine fetal serum at 30-40 deg.C, exchanging the culture solution once - twice a week, continuing the culture and treating the cell which has started natural growth, by limiting dilution analysis.
The invention relates to a novel chelated calcium, which is composed of 50 parts of L-aspartate trehalose, vitamin C37 and sucralose. The chelate calcium is prepared through solution preparation, filtration, chelation, drying and stirring, sieving and sterilization. An international leading chelation theory is adopted, and the collapse of cavitation and high-frequency high-voltage ultrasonic methods are used to reach the molecular resonance frequency, so as to chelate multiple molecules that are extremely difficult to react. The chelated calcium is formed through operations of the molecule chelating nano-energy conversion device. Each calcium ion together with two amino acids chelated therewith is absorbed by intestine in a wrapped manner, and the absorption rate reaches 95%. The chelate calcium has good taste and can be directly taken without side effects. The production process is reasonable, simple, easy to operate and easy to implement in industrial production.
Immune tolerance after kidney transplant will be induced by transfusion of enriched donor blood stem cells and T cells to initiate blood cell mixed chimerism in patients conditioned with total lymphoid irradiation and rabbit anti-thymocyte globulin after kidney transplant. Patients will receive corticosteroids for 14 weeks with gradual dose reduction. They will also receive 12 months of mycophenolate mofetil and 18 months of tacrolimus with dose tapering beginning 9 months post-transplant and continuing as long as mixed chimerism is maintained and there is no evidence of graft versus host disease and no kidney rejection evident. Patients losing chimerism will continue on low dose immunosuppressive drug doses unless additional kidney rejection therapy is needed.
Ivermectin cream applied once daily at bedtime was evaluated in the treatment of inflammatory lesions of rosacea in two randomized, double-blind, vehicle controlled clinical trials, which were identical in design. The trials were conducted in 1371 subjects aged 18 years and older who were treated once daily for 12 weeks with either Ivermectin cream or vehicle cream.

Overall, 96% of subjects were Caucasian and 67% were female. Using the 5-point Investigator Global Assessment (IGA) scale (0=clear, 1=almost clear, 2=mild, 3=moderate, 4=severe), 79% of subjects were scored as moderate (IGA=3) and 21% scored as severe (IGA= 4) at baseline.

The co-primary efficacy endpoints in both pivotal trials were the success rate based on the IGA outcome (percentage of subjects “clear” and “almost clear”) and absolute change from baseline in inflammatory lesion counts at Week 12. Table 1 presents the co-primary efficacy results at Week 12. Ivermectin cream was more effective than vehicle cream on the co-primary efficacy endpoints starting from 4 weeks of treatment in both studies, see Figures 1 through 4.

Figures 1 and 2: IGA Success Rates Over Time

Figures 3 and 4: Mean Absolute Change in Inflammatory Lesion Counts from Baseline Over Time
The objective of the protocol is to determine the pathogenesis of cough in diseases of the aerodigestive tract. There were over 24 million ambulatory chronic cough visits nationally in 1991 and over 8,000 visits in 2004 at MCR. Current guidelines for chronic cough are based on case series and on empirical expert opinions. Studies have implicated mucosal inflammation, heightened sensitivity of capsaicin cough receptors on peripheral nerves and elaboration of inflammatory mediators including tussigenic neuropeptides. There are gaps in our knowledge of what triggers cough in many disease states. For example, postnasal drip syndrome has been estimated to account for 70% of chronic cough, yet it is known that not all patients with postnasal drip have chronic cough. Our hypothesis is that there must be critical factor/s that cause cough in one patient with postnasal drip but not in another. This study will evaluate whether there exists differences in capsaicin cough sensitivity, neuropeptides levels and mucosal inflammation in patients with postnasal drip and chronic cough and compared to its natural control group, subjects with postnasal drip with and without chronic cough. After standard therapy to eliminate postnasal drip, repeat measurement of capsaicin sensitivity and nitric oxide levels will be obtained. There is a critical need to determine the mechanisms underlying cough for better management. The study results will provide insight and fill gaps in our knowledge and will serve to advance future work evaluating mechanisms of cough in other disease states including asthma, GERD, interstitial lung disease and smokers.
A device for treating a disease merging a small intestine meridian and a stomach meridian is a device applied for treating a disease merging a small intestine meridian and a stomach meridian by guiding traditional Chinese medicine (TCM) into a human body through the skin. The device is composed of a foreign material discharge bucket, a medicine guiding bucket, an auxiliary bucket, an ozone generator, a foreign material discharge ultrasonic generator, an ultrasonic medicine vibrator, a medicine guiding ultrasonic generator and a TCM prescription specialized for treating the disease merging the small intestine meridian and the stomach meridian. The ozone generator, the foreign material discharge ultrasonic generator, the ultrasonic medicine vibrator and the medicine guiding bucket are located beside the foreign material discharge bucket. The ozone generator is communicated with the foreign material discharge bucket, the medicine guiding bucket and the auxiliary bucket through an air pipe. Purified water and TCM decoction prepared inside the ultrasonic medicine vibrator and applied for treating the disease merging the small intestine meridian and the stomach meridian are placed inside the medicine guiding bucket. The device in the utility model makes the TCM molecules not decomposed and removes foul materials inside the human body. The device which treats diseases merging the small intestine meridian and the stomach meridian can be clinically applied.
The participants in the intervention group will be asked to identify an unfavourable behaviour that they wish to change when filling out the baseline questionnaire. The research nurse will conduct the individual face-to-face brief MI interviews for this purpose, which will last for approximately five to ten minutes. After the face-to-face brief MI interviews, the participants in the intervention group will receive brief MI messages individually by means of mobile instant messaging for six months from the baseline. After six months, the brief MI messages will cease to be delivered to the participants in the intervention group, with whom the research team will then maintain only minimal contact until the 12-month follow-up.
Sickle cell disease is a severe monogenic disorder which affects approximately 80,000 patients in the US. It is characterized by a vasculopathy with involvement of multiple organs and resulting in complications such as ischemic stroke, pulmonary hypertension, autosplenectomy, priapism, as well as chronic kidney disease (CKD). Despite the high prevalence of CKD and its known association with increased mortality, the natural history of CKD and the factors associated with changes in kidney function in patients with SCD remain incompletely defined. Furthermore, the available treatment options for albuminuria, an early manifestation of CKD, in patients with SCD are limited. In fact, no controlled studies have confirmed the long-term efficacy of angiotensin-converting enzyme (ACE) inhibitors, the current "standard of care." There is increasing evidence for a contribution of endothelial dysfunction to the pathophysiology of albuminuria in SCD. The association of biomarkers of endothelial function with albuminuria provides opportunities, not only to assess the effect of therapies which improve endothelial function, but also to evaluate the predictive value of these biomarkers for a decline in kidney function. The long-range goal is to develop a model to identify patients at particularly high risk for a decline in kidney function.

In this study, the investigators will evaluate rate of change in kidney function (decline in estimated glomerular filtration rates and increase in albuminuria) and identify biomarkers of endothelial function, metabolomic profiles and clinical characteristics for the worsening of kidney function and for a rapid decline in kidney function. At the conclusion of this proposed work, the investigators will have an improved understanding of the natural history of CKD in sickle cell anemia. With the limited available therapies for the treatment of albuminuria in SCD and the paucity of data on the long-term efficacy of available pharmacotherapies, identification of biomarkers for the progression of CKD will facilitate the development of treatments which may be more effective than the current "standard of care."
The determination of parameters affecting the performance of high performance athletes that are effective in performance is very important to determine the physical performance potential. The body is a kinetic chain and core muscles play an important role in this chain. The relationship between the performance ability of the athletes and the relationship between the core muscles and performance abilities and respiratory function is extremely important. Different functional classifications caused by different barriers (physical, mental or visual) in many paralympic branches affect physical training because it is directly related to the classification, performance and training adaptations of an athlete. Determining the parameters that affect the respiratory function of paralympics is very important to develop a training program with strategies that can affect the physical performance of athletes and thus to achieve the desired results in training and competitions. Therefore, the aim of this study was to investigate the relationship between respiratory muscle strength and core muscle strength in paralympic athletes (athletes with disability).
INTRODUCTION: Proactive esophageal cooling has been FDA cleared to reduce the likelihood of ablation-related esophageal injury resulting from radiofrequency (RF) cardiac ablation procedures. Data suggest that procedure times for RF pulmonary vein isolation (PVI) also decrease when proactive esophageal cooling is employed instead of luminal esophageal temperature (LET) monitoring. Reduced procedure times may allow increased electrophysiology (EP) lab throughput. We aimed to quantify the change in EP lab throughput of PVI cases after the introduction of proactive esophageal cooling.
METHODS: EP lab throughput data were obtained from three EP groups. We then compared EP lab throughput over equal time frames at each site before (pre-adoption) and after (post-adoption) the adoption of proactive esophageal cooling.
RESULTS: Over the time frame of the study, a total of 2498 PVIs were performed over a combined 74 months, with cooling adopted in September 2021, November 2021, and March 2022 at each respective site. In the pre-adoption time frame, 1026 PVIs were performed using a combination of LET monitoring with the addition of esophageal deviation when deemed necessary by the operator. In the post-adoption time frame, 1472 PVIs were performed using exclusively proactive esophageal cooling, representing a mean 43% increase in throughput (p < .0001), despite the loss of two operators during the post-adoption time frame.
CONCLUSION: Adoption of proactive esophageal cooling during PVI ablation procedures is associated with a significant increase in EP lab throughput, even after a reduction in total number of operating physicians in the post-adoption group.
The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1 cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone. Methods of treating or preventing a loss of bone mass, methods of inducing increased bone mass, and methods of inducing Wnt activity are also provided.
Large benign thyroid nodules （BTNs）usually cause compressive symptoms or cosmetic concerns and therefore require treatment. Thyroidectomy remains the mainstay treatment for large, symptomatic BTNs. However, if surgery is not feasible or refused, ablative approach could be considered in selected patients. However, it has been proved that single application of thermal ablation is less effective in causing shrinkage in large thyroid nodules. The possible reason is that it is difficult for single application of thermal ablation to cover all of the nodule tissue in a three-dimension if the nodule is large. In addition, nodule locations adjacent to vital structures might hinder complete treatment in one session because of safety concerns. Few studies reveal that staged thermal ablation (Pre-designed multiple sessions of thermal ablation) can also achieve complete ablation and adequate volume reduction of large benign thyroid nodules. However, there is a lack of comparison between these two methods. Thus, this study is aimed to compare the safety, efficacy, quality of life between staged thermal ablation and thyroidectomy for treating large benign thyroid nodules.
TIME™ at Home is a licensed, pre-recorded video-based, group, community exercise program. One program will have a maximum of 10 participants registered. March of Dimes Canada will run two programs. A 1.5-hour session will be hosted by two facilitators using Zoom twice a week for 8 weeks, starting with the Level 1 video (beginner level). All participants will switch to the Level 2 video (advanced level) mid-program.
Almonds are energy-dense and rich in beneficial nutrients including B vitamins, vitamin E, mono- and polyunsaturated fatty acids, protein, fiber, minerals and polyphenols. Polyphenols and vitamin E in almonds provide protection to the body in part, through their ability to combat oxidative stress. Clinical studies have demonstrated beneficial effects of almond consumption on diseases such as diabetes and cardiovascular disease.

Almond consumption has been shown to significantly decrease wrinkle severity in two clinical studies conducted with postmenopausal women with Fitzpatrick skin type I and II. Almond intake has also been shown to increase resistance to erythema induced by ultraviolet exposure. The extracellular matrix contains proteins including collagen and elastin, which contributes to the integrity of the skin. Enzymatic and ultraviolet radiation induced degradation and a reduction in synthesis of collagen and elastin contribute to wrinkle formation. Furthermore, the process of menopause decreases the level of estrogen which affects the skin in several ways, including a decrease in skin collagen and hydration, and an increase in wrinkling.
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) has demonstrated efficacy in alleviating leg pain among patients with lumbar disc herniation. Nonetheless, residual back pain persists as a troubling issue for surgeons following the procedure. In the treatment of discogenic back pain, sinuvertebral nerve radiofrequency ablation has shown promising results. Nevertheless, the potential benefit of simultaneously implementing sinuvertebral nerve radiofrequency ablation during PELD surgery to address residual back pain has not been thoroughly investigated in current literature.
METHODS: This retrospective study reviewed Lumbar disc herniation (LDH) patients with low back pain who underwent combined PELD and sinuvertebral nerve ablation in our department between January 2021 and September 2023. Residual low back pain post-surgery was assessed and compared with existing literature.
RESULTS: A total of 80 patients, including 53 males and 27 females, were included in the study. Following surgical intervention, patients demonstrated remarkable improvements in pain and functional parameters. One month post-operatively, the VAS score for low back pain exhibited a 75% reduction (6.45 ± 1.3 to 1.61 ± 1.67), while the VAS score for leg pain decreased by 85% (7.89 ± 1.15 to 1.18 ± 1.26). Notably, the JOA score increased from 12.89 ± 5.48 to 25.35 ± 4.96, and the ODI score decreased form 59.48 ± 9.58 to 20.3 ± 5.37. These improvements were sustained at three months post-operatively. According to the modified Mac Nab criteria, the excellent and good rate was 88.75%. Residual low back pain is observed to be comparatively reduced compared to the findings documented in earlier literature.
CONCLUSION: The combination of percutaneous endoscopic lumbar discectomy and sinuvertebral nerve ablation demonstrates effective improvement in low back pain for LDH patients.
BACKGROUND: In the 21st century, endoscopic retrograde cholangiopancreatography (ERCP) has emerged as a diagnostic and therapeutic method for diseases of the pancreaticobiliary duct system. However, like any other diagnostic and therapeutic method, ERCP carries the risk of unwanted complications.
MATERIAL AND METHODS: We retrospectively followed patients who underwent ERCP examinations from January 2013 to April 2023. We focused on early post-ERCP complications and their risk factors, prevention, treatment, and mortality.
RESULTS: A total of 4,814 patients were recorded, of which 175 patients had early post-ERCP complications, including acute pancreatitis, acute cholangitis, perforation, and bleeding. We focused on the statistical significance of risk factors such as BMI, repeated ERCP, bleeding disorders, and repeated pancreatitis or cholangitis.
CONCLUSION: Ensuring proper preparation and appropriate indication for ERCP examination can significantly mitigate the risk of post-ERCP complications. Additionally, early diagnosis and prompt treatment of any post-ERCP complications are essential strategies for reducing mortality associated with these conditions (Tab. 3, Fig. 3, Ref. 32). Text in PDF www.elis.sk Keywords: post-ERCP complication, risk factor, BMI, prevention.
OBJECTIVES: Methotrexate (MTX) is an antimetabolite agent widely used to manage a variety of tumors and autoimmune diseases. Nonetheless, MTX-induced intestinal intoxication is a serious adverse effect limiting its clinical utility. Inflammation and oxidative stress are possible mechanisms for MTX-induced intestinal toxicity. Vinpocetine (VNP) is a derivative of the alkaloid vincamine with potent anti-inflammatory and antioxidant effects. The current study investigated the protective intestinal impact of VNP in attenuating MTX-induced intestinal intoxication in rats.
MATERIALS AND METHODS: VNP was administered orally in a dose of 20 mg/kg, while MTX was injected intraperitoneal in a dose of 20 mg/kg.
RESULTS: VNP administration attenuated drastic histological changes induced by MTX and preserved both normal villus and crypt histology. VNP significantly attenuated oxidative injury by upregulating intestinal Nrf2 and HO-1 expression. VNP attenuated inflammation by reducing MPO, NO2-, TNF-α, and IL-1β levels mediated by downregulating NF-κB, NDAPH-oxidase, IRF3, p-JAK-1, and p-STAT-3 expressions. Moreover, VNP potently counteracted intestinal necroptosis by effectively downregulating RIPK1, RIPK3, MLKL, and caspase-8 proteins.
CONCLUSION: Therefore, VNP may represent a promising approach that can attenuate intestinal toxicity in patients receiving MTX.
1516525 Anhydrous compositions for remineralizing tooth enamel PROCTER & GAMBLE CO 9 Oct 1975 [10 Oct 1974] 41435/75 Heading A5B Anhydrous compositions for the remineralizing of demineralized dental enamel e.g. dentifrices, mouthwashes, toothpastes, chewing gums and dental prophylaxis pastes comprise (A) a water-soluble calcium salt e.g. calcium chloride, acetate, formate, lactate or nitrate; (B) a water-soluble phosphate salt e.g. disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, trisodium phosphate and anhydrous phosphoric acid; (C) the balance, anhydrous ingredients for use in the oral cavity; wherein the molar ratio of calcium to phosphate is from 0.01:1 to 100:1, and the composition, when dispersed in water at a concentration of 1 part by weight of composition to 2 parts by weight of water, produces a pH of from 2 to 5. Additional ingredients include a watersoluble salt of magnesium or a heavy metal such as manganese, tin, zinc, indium, aluminium, zirconium, iron, titanium, vanadium and the rare earth metals e.g. lanthanum and cerium; a water soluble salt of an anion capable of forming a water-insoluble precipitate with the cations of calcium, magnesium or the above specified heavy metals e.g. fluoride; and other conventional dentifrice components.
[GB1516525A]