anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1,184,044. Nitrofuryl-oxadiazole derivatives. E. R. SQUIBB & SONS Inc. 13 March, 1967 [14 March, 1966; 22 July, 1966], No. 11689/67. Heading C2C. Novel compounds of formula wherein n is 0, 1 or 2 and R 1  and R 2  each represent H or acyl, or R 1  and R 2  each represent H, C 1-8  alkyl, hydroxy (C 1-8 ) alkyl or acyl only one of R 1  or R 2  being H, or R 1  and R 2  together with the nitrogen atom form a saturated 6- membered heterocyclic ring which may contain O, S or a further N, are prepared either by reaction of a compound of formula HNR 1 R 2  and a compound of formula wherein X is halogen or trichloromethyl, optionally followed by acylation if both R 1  and R 2  and H, or by direct nitrution optionally with simultaneous acylation of a compound of formula Pharmaceutical compositions having antimicrobial activity and being in conventional forms for oral or topical administration comprise an above-novel compound and a carrier therefor.
The SAGE LEAF 2 study is a single-arm fully online implementation trial of the SAGE LEAF program delivered to family caregivers through Caregiver Serving Organizations (CSOs). The SAGE LEAF intervention is 8 weeks long and involves weekly self-guided positive emotion skill lessons, daily skill practice exercises, and daily emotion reporting, all housed on the SAGE LEAF website. The website also includes social features, such as a discussion board and profile pages, to facilitate social connection among participants. Up to n=140 family caregivers of individuals with dementia will be recruited through CSOs and the general population. To participate, caregivers must (1) identify as the primary family caregiver of a person with Alzheimer's disease, (2) be at least 18 years old, (3) speak and read English, and (4) have access to high-speed internet. Participants will complete survey assessments via REDCap before and after they go through the SAGE LEAF intervention. All study activities will take place online.

Individual level effectiveness will be assessed using self-reported outcomes, such as positive affect, caregiver burden, loneliness, and depression. These outcomes will be measured both pre- and post-intervention. Implementation barriers and facilitators will be assessed using follow-up qualitative interviews.
BACKGROUND: Obstructive sleep apnea (OSA), due to its high prevalence, has been associated with a number of comorbidities, frequently impacting the overall course of these other diseases if left untreated. Recent studies highlight a potential association between OSA and cancer. This study investigates how OSA severity and hypoxia affect cancer prognosis, aiming to elucidate how they interplay.
METHODS: Retrospective study including patients with a diagnosis of OSA after any cancer type followed up in a tertiary center during a 10-year period. OSA was mainly diagnosed after level III polysomnographic studies.
RESULTS: Nocturnal hypoxia was significantly more prevalent in patients presenting lung cancer versus other malignancies and was associated with higher rates of oncologic disease progression. Overall survival was significantly lower in severe OSA patients and also in patients presenting nocturnal hypoxia. A composite hypoxia score considering both OSA severity and significant hypoxia was an independent predictor of mortality regardless of clinical cancer staging and treatment. Shorter time between cancer and OSA diagnosis was also associated with worse prognosis.
CONCLUSION: This study suggests an association between OSA severity and nocturnal hypoxia and increased cancer mortality independently from possible confounding factors such as age, cancer clinical staging at diagnosis, treatment modality and also progression. Neoplastic patients with severe OSA and/or complex hypoxia seem to have lower overall survival rates than those with less severe OSA and nocturnal hypoxia.
People with epilepsy frequently under- or inaccurately report their seizures, which poses a challenge for evaluating their treatment. The introduction of epilepsy health apps provides a novel approach that could improve seizure documentation. This study assessed the documentation performance of an app-based seizure diary and a conventional paper seizure diary. At two tertiary epilepsy centers patients were asked to use one of two offered methods to report their seizures (paper or app diary) during their stay in the epilepsy monitoring unit. The performances of both methods were assessed based on the gold standard of video-EEG annotations. In total 89 adults (54 paper and 35 app users) with focal epilepsy were included in the analysis, of which 58 (33 paper and 25 app users) experienced at least one seizure and made at least one seizure diary entry. We observed a high precision of 85.7% for the app group, whereas the paper group's precision was lower due to overreporting (66.9%). Sensitivity was similar for both methods. Our findings imply that performance of seizure self-reporting is patient-dependent but is more precise for patients who are willing to use digital apps. This may be relevant for treatment decisions and future clinical trial design.
ETHNOPHARMACOLOGICAL RELEVANCE: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.) Miq. or Stemona japonica (Blume) Miq. (The plant name has been checked with http://www.theplantlist.org), of which multiple biological activities has been verified. However, whether it may alleviate pulmonary fibrosis via regulating ferroptosis mechanism has not been confirmed.
AIM OF THE STUDY: The aim of this study is to observe whether tuberostemonine alleviates pulmonary fibrosis by enhancing the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis.
MATERIALS AND METHODS: We validated the effects of tuberostemonine and ferroptosis on TGF-β1-induced proliferation of human lung fibroblast and bleomycin-induced pulmonary fibrosis in mice. In vitro, the ferroptosis effect of TGF-β1 on human lung fibroblast were examined and the activity of ɑ-SMA, collagen, hydroxyproline and ferrous ions in cells were also examined. In vivo, ferroptosis impacts respiratory function. Inflammatory manifestations, hydroxyproline, collagen activity and ferrous ions in the lung or blood were subject to evaluation.
RESULTS: Tuberostemonine significantly improved respiratory function in mice with bleomycin-induced pulmonary fibrosis, decreased cellular and lung hydroxyproline content, reduced inflammation and collagen deposition in cells and lung, and promoted an increase in the SLC7A11 and GPX4 proteins. Tuberostemonine inhibits the ferroptosis phenomenon, up-regulates SLC7A11, GPX4 and GSH, and down-regulates the accumulation of iron and ROS.
CONCLUSIONS: Tuberostemonine significantly inhibited ferroptosis and improved pulmonary fibrosis both in vivo and vitro.
Will perform the eccentric muscle damage exercise and will begin the icing intervention immediately after the muscle damage. The icing protocol will be icing the elbow flexor muscles for 10 minutes with a cold pack followed by 10 minutes with no icing and another 10 minutes of elbow flexor muscle icing. The participants will perform this protocol every day at approximately the same time for the duration of the study.
Patient activation, which incorporates elements of self-efficacy and readiness to change, is particularly important in managing conditions like pre-diabetes, where the mainstay of treatment is behavioral lifestyle change and self-management. Unfortunately, Primary Care Physicians (PCPs) often do not have adequate training on how to promote patient activation. Traditionally, patient decision aids are used in shared decision-making to help elicit patient preferences and guide treatment options. However, the guides primarily focus on reviewing treatment options rather than increasing patient activation, which is key to successful and efficient behavioral counseling. The Patient Activation Measure (PAM) is a widely used and validated patient-reported outcome measure for assessing patient activation. Studies have demonstrated that using PAM to tailor care to a patient's activation level decreased health service utilization while improving clinical outcomes like blood pressure and self-management behaviors.

The investigators overarching goal is to increase the percentage of patients engaging in diabetes prevention activities to reduce the incidence of diabetes. The investigators objective is to design and pilot test a pre-diabetes clinical decision support (CDS) tool in the electronic health record (EHR) that will assess the patient's activation level based on responses to a questionnaire. Based on the patient's assessed level of activation, the tool will generate several communication recommendations to guide clinicians in conversations related to pre-diabetes/lifestyle change and tailor recommendations about available resources (e.g., care manager, health coach, DPP) to support patient activation.
OBJECTIVE: Electrodiagnostic testing is an important screening test for myotonic dystrophy type 1 (DM1). Although myotonic discharges are observed on electromyography in cases of DM1, it is difficult to distinguish DM1 from other myotonic disorders clinically. In the present study, afterdischarges, another type of pathological potential revealed by electrodiagnostic testing, were analyzed, and their role in distinguishing DM1 from other myotonic disorders was explored.
METHODS: Data from 33 patients with myotonic discharges on electromyography were analyzed retrospectively. According to gene testing, the patients were divided into DM1 (n = 20) and non-DM1 myotonia (n = 13) groups. Afterdischarges were investigated by retrospectively evaluating the electrodiagnostic findings of motor nerve conduction studies, F-waves, and repetitive nerve stimulations.
RESULTS: Afterdischarges were observed in 17 of the 20 patients with DM1, with an occurrence rate of approximately 85%. However, afterdischarges were absent in all patients with non-DM1 myotonia. There were significant differences in the occurrence rate between the two groups (P < 0.01).
CONCLUSION: Afterdischarges may serve as a suggestive role in clinical diagnosis of DM1. The discovery that DM1 can present with afterdischarges may pave a new way to study the pathogenesis of DM1.
Participants will undergo a 4-week intervention (once per week, 1 hour each session). Each intervention session consists of approximately 30 minutes of computerized cognitive behavioral therapy, and 30 minutes of Virtual Reality Exposure Therapy with our novel arousal-based biofeedback system. For Virtual Reality Exposure Therapy, the physiological variables of participants will be continuously monitored and presented to them as feedback. Participants will have to deliver speeches to videotaped audiences while striving to regulate their physiological arousal.
Hysterectomy is one of the most common surgical procedures performed on women in the United States, with approximately 600,000 performed annually. The use of postoperative cooling as an adjuvant for post-operative pain control has previously been shown to be effective and safe in a variety of procedures, but has yet to be described for laparoscopic surgery. In contrast to laparotomy where the wound is a significant pain generator and direct application of ice is intuitive, in laparoscopic surgery much of the pain-generating tissue trauma is intraperitoneal and pelvic in nature, away from the abdominal wall. Ice pack use on the abdominal wall likely inhibits visceral afferent pain fibers via somatic afferent nerve cross-talk. Accordingly, applying ice to the abdominal wall and its somatic afferents may improve laparoscopic pain control, despite the lack of a significant abdominal wound. Our goal is to quantify narcotic use after hospital discharge following hysterectomy, and evaluate the effectiveness of abdominal ice packs as low cost adjuncts for pain control.
OBJECTIVE: To assess the effectiveness and safety of a topical silicone gel (BE + Gel reductor y reparador de cicatrices) and a polyurethane dressing (BE + Apósito reductor y reparador de cicatrices) on the evolution of scars of patients who were previously recruited in the emergency care unit while seeking wound care.
METHOD: A single center, stratified observational, open label study was performed in the emergency care unit of Donostia Universitary Hospital (recruitment) and in the Biodonostia Health Research Institute (intervention). Scars located in unexposed body areas with the dressing, and scars located in exposed areas with either the gel or the dressing. Investigators assessed interventions at day 1 and on weeks 4, 8 and 12. Vancouver Scar Scale (VSS) and a photographical assessment were used to determine the scars evolution, and the subjective perception of the scar was evaluated by means of a questionnaire administered to the patients.
RESULTS: Patients whose scars were treated with the silicone gel had an average initial VSS score of 5.4 ± 2.08. This value was reduced to 0.86 ± 1.17 after 90 days of treatment. Patients treated with the polyurethane dressing had an average initial VSS score of 5.8 ± 2.29. After 90 days of treatment, this average score was reduced to 0.33 ± 0.66. Positive evolution of scars was also supported by photographs and by a patient questionnaire.
CONCLUSIONS: Both treatments appear to be safe and effective, objectively, and subjectively, in the context of scar evolution.
PURPOSE: A hair penetrating nanometal particle for shielding radio waves is provided to block harmful radio waves generated when using a mobile phone and to keep talking on the phone without changing a posture. CONSTITUTION: A nanometal particle blocks radio waves by being penetrated into hair. The nanometal particle-penetrated hair blocks harmful radio waves generated when using a mobile phone. The nanometal particle has an effect by positioning the mobile phone on hair with proper length and quantity of hair when talking on the phone. The length of hair has to be longer than the size of the mobile phone. The quantity of hair affects the intensity of the harmful radio waves generated from the mobile phone.
A vaccine composition including an immunogenic hybrid polypeptide is provided to be applicable to animals such as dog, cow, and cat as well as human and induce a uniform antibody reaction between individuals, thereby being effective for preventing and treating obesity of the human and animals. An immunogenic polypeptide is characterized in that it is fused with: (a) a monomer or a polymer of a peptide having an amino acid sequence selected from SEQ ID : NOs. 1, 2 and 3; (b) a rabies virus helper T cell epitope or a hepatitis B virus surface antigen helper T cell epitope linked to a C-terminal of the monomer or polymer of the peptide; and (c) a C-terminal peptide fragment of a mouse apolipoprotein CII or the monomer or the polymer having the amino acid sequence selected from the SEQ ID : NOs. 1, 2 and 3 linked to a C-terminal of the helper T cell epitope. A vaccine for preventing or treating obesity comprises the immunogenic hybrid polypeptide. A method for preparing the immunogenic hybrid polypeptide comprises a step of culturing a host cell transformed by a recombinant expression vector including a polynucleotide coding the polypeptide.
PROBLEM TO BE SOLVED: To easily fetch clear images by fetching the image signals outputted from a photographing device and generating the image data corresponding to an object image when the time of a timer means is coincident with its set time after an instruction is inputted from a photographing instruction means. SOLUTION: The position of a photographing device 11 is decided to obtain a desired image of an object, and a photographing instruction is given via a keyboard or a mouse 25, etc., serving as a photographing instruction means. Thus, a timer parts 34 starts its counting. Then the remaining number of seconds is shown on the screen of a display device 22, for example, in a count- down mode or the tones are produced from a speaker 41 every second, for example. An image fetch signal S3 is instantaneously produced at a set time, and an image data generation part 31 fetches the image signals S1a and converts them into the image data D1. When plural photographing sheets are set, the signals S3 are outputted in plural times and plural data D1 are generated.
Participants will receive apomorphine via a pump. Participants in the Continuous Delivery Arm will self-administer apomorphine continuously (12-14 hours a day) using a portable pump.
Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e. substitution of one of the hydrogens by methyl) demonstrated chiral discrimination in proteasome CT-L activity inhibition (the S-enantiomer was 35-40 fold more potent than the R-enantiomer).
NEW MATERIAL:The compound of formula I [R1 is H or 1-5C straight or branched chain alkyl; R2 is lower alkoxycarbonyl, carboxyl or tetrazolyl; R3 is R1 or (substituted)phenyl; R4 is H or together with R3 form butadienylene of formula VII (R5-R8 are R1, OH, OCH3, halogen, etc.) which forms a condensed benzene ring] and its salt. USE:A drug. A leucotriene antagonistic agent. Effective in the prevention and remedy for allergic diseases such as asthma, cerebral edema caused by cerebral ischemia, stenocardia caused by cerebral vessel constriction or decrease in coronary blood flow, etc. PREPARATION:The compound of formula I wherein R2 is lower alkoxycarbonyl can be produced by carrying out dehydrative condensation reaction of a compound of formula II (Ra is lower alkyl) with a compound of formula III, breaking the phenyl ether bond of the resultant compound of formula IV with Lewis acid, etc., to obtain a compound of formula V and reacting the product with a compound of formula VI (Rb is 1-5C alkyl; X is Cl, Br or I).
PURPOSE: To objectify the indication for re-bubbling by analyzing graft detachments (GDs) after Descemet membrane endothelial keratoplasty.
METHODS: In this retrospective monocentric observational study, re-bubbling cases of 450 Descemet membrane endothelial keratoplasties and the percentage of the residual gas filling (RGF) in the anterior chamber on the first postoperative day were collected. The number/location/extent of GDs and the corneal thickness above GDs were analyzed using anterior segment optical coherence tomography.
RESULTS: From a total of 450 grafts, 384 (85.3%) had at least a minimal degree GD. One hundred twenty-two of 450 grafts (27.1%) underwent at least 1 re-bubbling. The mean RGF was significantly lower in eyes with GD (67.7 ± 12.6%) than in eyes without GD (74.2 ± 11.3%). GDs occurred most frequently in the inferotemporal quadrant (46.0%). GDs were significantly more likely to require a re-bubbling when the central parts of the graft were affected (94.0% vs. 35.7%). The number of detachments per graft was directly proportional to the re-bubbling rate. The GDs which required a re-bubbling were on average 56 μm higher and 461 μm wider than the untreated ones. The cornea above the GDs that needed a re-bubbling was significantly thicker than above the untreated GDs (mean 988 ± 102 μm vs. 951 ± 99 μm).
CONCLUSIONS: The RGF seems to be a major influencing factor for graft attachment. The most susceptible location of the GD is inferotemporal. The main factors that need to be investigated to decide if a re-bubbling is required are the number of detachments per graft, their dimensions, whether the central portions of the graft are involved, and the corneal thickness above GDs.
FIELD: medicine; biochemistry.SUBSTANCE: invention relates to biotechnology and biochemistry, in particular to a cell penetrating peptide. Said peptide consists of an amino acid sequence of SEQ ID NO: 1 and is capable of mediating intracellular delivery of a botulinum light chain. Invention also relates to a conjugate for intracellular delivery of a botulinum toxin light chain. In said conjugate, the botulinum toxin light chain is conjugated at one or both ends with an amino acid sequence of SEQ ID NO: 1. Invention also relates to a vector and to a bacterium expressing said conjugate. Present invention relates to cosmetic and pharmaceutical compositions comprising said conjugate and are intended for the treatment of dermatological diseases.EFFECT: invention allows obtaining compositions for the treatment of dermatological diseases.23 cl, 15 dwg, 1 tbl, 13 ex
The invention relates to a traditional Chinese medicine composition for treating motility dysfunction-type dyspepsia. The traditional Chinese medicine composition comprises, by weight, 30-40 parts of radish seed, 30-40 parts of chicken's gizzard membrane, 30-40 parts of Chinese garlic, 10-20 parts of pogostemon cablin, 10-20 parts of loquat leaf, 10-20 parts of pawpaw, 10-20 parts of santal, 10-20 parts of galagal rhizome, 5-10 parts of fingered citron, 5-10 parts of bitter orange, 5-10 parts of green tangerine peel and 1-5 parts of rose. Radish seed having effects of helping digestion and eliminating swelling, Chicken's gizzard membrane having effects of helping digestion and strengthening stomach and Chinese garlic having effects of promoting the circulation of qi and removing food stagnation are used as monarch drugs. Pogostemon cablin having effects of preventing or arresting vomiting, loquat leaf having effects of calming the adverse-rising energy and preventing or arresting vomiting, pawpaw having effects of eliminating dampness and harmonizing stomach, santal having effects of rectifying qi and regulating the center, and dispelling cold and relieving pain, and galagal rhizome having effects of dispelling cold and relieving pain, and warming the middle warmer and preventing or arresting vomiting are used as minister drugs. Fingered citron having effects of rectifying qi and regulating the middle warmer, bitter orange having effects of relieving stagnant qi and removing food retention, and green tangerine peel having effects of removing food retention and transforming stagnation are used as assistant drugs. Rose having effects of promoting the circulation of qi and promoting blood circulation to arrest pain is used as a guide drug. Through combination of the twelve traditional Chinese medicines, the traditional Chinese medicine composition has effects of helping digestion and strengthening stomach, and harmonizing the stomach and preventing or arresting vomiting. The traditional Chinese medicine composition has a reasonable formula, is convenient and safe in use, has no side effects, has a low treatment cost and realizes simultaneous treatment of principal and subordinate symptoms.