anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This experiment was designed to explore how different types of probiotics affect the growth, carcass traits, and seasonal variations in growing New Zealand White rabbits (NZW). Two parallel experiments using the same strain of NZW during winter and summer, each alone from 5 to 13 weeks of age. Each experiment uses a total of 125 unsexed rabbits. These rabbits are separated into 5 groups of 25 rabbits each. Each group has five replicates, with five rabbits in every replicate. In each experiment, 1st group acting as the control group did not receive any probiotics. The 2nd was given a dose of 1 ml of Bifidobacterium bifidum, the 3rd received a dose of 1 ml of Lactobacillus acidophilus, and the 4th was treated with a 1 ml blend of both Bifidobacterium bifidum and Lactobacillus acidophilus, and 5th group was treated with 1 ml of Saccharomyces cerevisiae. Results indicated that the Bifidobacterium bifidum group had the best live body weight (LBW) values and daily weight gain (DWG). Meanwhile, during summer, the Lactobacillus acidophilus group had the best feed conversion ratio (FCR) and performance index (PI) values. Also, growing rabbits fed Lactobacillus acidophilus and Bifidobacterium bifiduim had significantly increased carcass traits during the summer and winter seasons. Furthermore, seasonal changes indicated that the Bifidobacterium bifiduim group improved LBW, DWG, and PI during summer than winter. So, it could be concluded that using Bifidobacterium bifidum can enhance rabbit growth by improving feed utilization and carcass traits, making it an effective addition to hot weather diets.
Suboptimal early infant feeding practices are the norm in Bangladesh, and contribute to its poor infant health and nutrition. However, the modern health services are unable to help because approximately 85% of births take place at home. The Government has begun the huge process of training the informal community traditional birth attendants (TBAs) who, along with community volunteers (CVs), deliver the majority of babies, especially in the rural areas. The proposed operations research will take place in one of the poorest rural districts. It will compare the cost effectiveness of practical training of these relatively uneducated community members, with or without supportive supervision in improving early infant feeding practices, using a cluster-randomized study design. The practices to be measured before and after on probability samples include: 1) delayed cord clamping, 2) early skin to skin contact and 3) newborn-led initiation of breastfeeding within one hour of birth, 4) avoidance of the traditional prelacteal feeds, and 5) exclusive breastfeeding, at least for the early months. Costs will be carefully monitored so as to compare the cost per behavior improved per infant.
Herpes zoster of trigeminal nerve was a common skin disease caused by varicella-zoster virus infection. Simple involvement of the third branch of trigeminal nerve was rare, and so were oral complications such as pulpitis, periodontitis, spontaneous tooth loss, bone necrosis, etc. This article presented a case of herpes zoster on the third branch of the left trigeminal nerve complicated with left mandibular osteonecrosis. We reported the case of a 64-year-old man with sudden pain in the left half of the tongue 1 month ago, and then herpes on the left facial skin appeared following with acute pain.The local hospital diagnosed it as herpes zoster and treated it with external medication. A few days later, he developed gum pain in the left mandibular posterior tooth area. He was admitted to Peking University School and Hospital of Stomatology one week ago with loose and dislodged left posterior tooth accompanied by left mandibular bone surface exposure. Clinical examination showed bilateral symmetry and no obvious restriction of mouth opening. Visible herpes zoster pigmentation and scarring on the left side of the face appeared. The left mandibular posterior tooth was missing, the exposed bone surface was about 1.5 cm×0.8 cm, and the surrounding gingiva was red and swollen, painful under pressure, with no discharge of pus. The remaining teeth in the mouth were all Ⅲ degree loosened. Imageological examination showed irregular low-density destruction of the left mandible bone, unclear boundary, and severe resorption of alveolar bone. The patient was diagnosed as left mandibular osteonecrosis. Under general anesthesia, left mandibular lesion exploration and curettage + left mandibular partial resection + adjacent flap transfer repair were performed. The patient was re-exmained 6 months after surgery, there was no redness, swelling or other abnormality in the gums and the herpes pigmentation on the left face was significantly reduced. Unfortunately, the patient had complications of postherpetic neuralgia. This case indicate that clinicians should improve their awareness of jaw necrosis, a serious oral complication of trigeminal zoster, and provide early treatment. After the inflammation was initially controlled, surgical treatment could be considered to remove the necrotic bone, curettage the inflammatory granulation tissue, and extraction of the focal teeth to avoid further deterioration of the disease.
BACKGROUND: Cirrhosis is a prevalent disease and ranks among the leading causes of death worldwide. Sarcopenia is believed to be associated with a poorer prognosis in patients with cirrhosis.
OBJECTIVE: To evaluate the impact of sarcopenia on the prognosis of patients hospitalized for acute decompensation of cirrhosis, with or without acute-on-chronic liver failure.
METHODS: This prospective cohort study evaluated patients hospitalized for acute decompensation of cirrhosis, with or without acute-on-chronic liver failure. Sarcopenia was assessed according to the European Working Group on Sarcopenia in Older People, using skeletal muscle mass analysis by bioelectrical impedance and handgrip strength testing. The data was collected between March-2019 and April-2020. Qualitative variables were presented as frequencies and percentages, and quantitative variables as means and standard deviations when symmetrical, or medians and 25th and 75th percentiles when asymmetrical. The association of sarcopenia and mortality with quantitative variables was tested using Student's t-test or the Mann-Whitney test, while associations with qualitative variables were tested using the Chi-square test or Fisher's Exact test. For significant associations, crude and adjusted (multivariate analysis) relative risk estimates with a 95% confidence interval were calculated using Poisson regression analysis. Results with P<0.05 were considered significant.
RESULTS: Fifty patients were included, with a mean age of 60.5 years (±10.4) and a slight predominance of men (56%). The main causes of cirrhosis were alcohol use disorder (28%) and hepatitis C (24%). The median Child-Pugh score was 8 points (7-10), and the median Model for End-stage Liver Disease score was 15 points (12.5-21). Ten patients were diagnosed with acute-on-chronic liver failure. Sarcopenia was present in 50% of the sample. Sarcopenia was present in 70.0% of patients with acute-on-chronic liver failure and in 43.2% of those without acute-on-chronic liver failure (P=0.168). Overall mortality was 48% in patients with sarcopenia and 44% in those without sarcopenia (P=1.000). In multivariate analysis, overall mortality was associated only with leukocyte count (relative risk=1.01, 95% confidence interval=1.01-1.01) and Model for End-stage Liver Disease score (relative risk=1.07, 95% confidence interval =1.03-1.10).
CONCLUSION: In this study, sarcopenia was not associated with mortality in patients hospitalized for acute decompensation of cirrhosis, with or without acute-on-chronic liver failure. There was a non-significant trend towards a higher prevalence of sarcopenia among individuals with acute-on-chronic liver failure.
The invention relates to a pantoprazole sodium freeze-dried powder injection pharmaceutical composition and a preparation method thereof. Specifically, the invention relates to a freeze-dried powder injection, which comprises pantoprazole sodium, mannitol, an acid-base regulator and the like. The invention also relates to a method for preparing the pantoprazole sodium freeze-dried powder injection. The invention also relates to a method for controlling the quality of the pantoprazole sodium freeze-dried powder injection. The pantoprazole sodium freeze-dried powder injection can be used for treating gastropathy and has expected good properties. For example, the pantoprazole sodium freeze-dried powder injection has excellent industrial production process and excellent quality control method.
PURPOSE:To provide inexpensive hemoferrum-containing biscuits useful for preventing asideritic anemia without any bloody malodor, taste, etc., by subjecting a hemoglobin obtained from livestocks, etc., to specific treatment and containing the resultant hemoferrum with a high iron content in biscuits. CONSTITUTION:Hemoglobin is collected from blood of livestocks and/or poultries. A proteolytic enzyme (e.g. alkaline protease) is then added to the resultant hemoglobin under alkaline conditions to carry out hydrolysis thereof. The enzyme, etc., are subsequently inactivated by a method for heating, etc. At least one selected from magnesium chloride, calcium chloride, potash alum and ammonium alum in the form of an aqueous solution is subsequently added to treat the aforementioned enzymically treated solution. An acid is then added to deposit hemoferrum at a high iron concentration. The hemoferrum with a high iron content is subsequently contained in biscuits to produce the hemoferrum-containing biscuits.
High dose cyclosporine weeks 1-6, then maintenance dose cyclosporine weeks 7-36. If CR, PR, or SD at week 36 evaluation, treatment is complete. If progression occurs during weeks 7-36, patients will re-register to Step 2 at time of PD and begin high dose therapy (weeks 1-6), followed by maintenance therapy (weeks 7-36). At second progression patients will end protocol treatment.
This group will supplement their regular diet with 3.0 grams of a combined omega-3-6-9 supplement in soft gel form on a daily basis for 12 weeks. This group will also complete a whole body progressive resistance training program 3 days per week for 12 weeks.
BACKGROUND: Neuroinflammation is a hallmark of the Alzheimer's disease (AD) pathogenic process. Cortisol dysregulation may increase AD risk and is related to brain atrophy. This cross-sectional study aims to examine interactions of cortisol patterns and neuroinflammation markers in their association with neuroimaging correlates.
METHOD: 134 participants were recruited from the Karolinska University Hospital memory clinic (Stockholm, Sweden). Four visual rating scales were applied to magnetic resonance imaging or computed tomography scans: medial temporal lobe atrophy (MTA), global cortical atrophy (GCA), white matter lesions (WML), and posterior atrophy. Participants provided saliva samples for assessment of diurnal cortisol patterns, and underwent lumbar punctures for cerebrospinal fluid (CSF) sampling. Three cortisol measures were used: the cortisol awakening response, total daily output, and the ratio of awakening to bedtime levels. Nineteen CSF neuroinflammation markers were categorized into five composite scores: proinflammatory cytokines, other cytokines, angiogenesis markers, vascular injury markers, and glial activation markers. Ordinal logistic regressions were conducted to assess associations between cortisol patterns, neuroinflammation scores, and visual rating scales, and interactions between cortisol patterns and neuroinflammation scores in relation to visual rating scales.
RESULT: Higher levels of angiogenesis markers were associated with more severe WML. Some evidence was found for interactions between dysregulated diurnal cortisol patterns and greater neuroinflammation-related biomarkers in relation to more severe GCA and WML. No associations were found between cortisol patterns and visual rating scales.
CONCLUSION: This study suggests an interplay between diurnal cortisol patterns and neuroinflammation in relation to brain structure. While this cross-sectional study does not provide information on causality or temporality, these findings suggest that neuroinflammation may be involved in the relationship between HPA-axis functioning and AD.
Objective: First generation antipsychotics would induce tardive dyskinesia in some schizophrenic patients. Second generation antipsychotics were the choices for these patients. But which one of second generation antipsychotic was the better choice did not have definitive results. We compared risperidone and olanzapine in schizophrenic patients with neuroleptic-induced tardive dyskinesia to see their effects in improving tardive dyskinesia. We also collected the data of average dose of risperidone and olanzapine to help the dosing strategy guidelines for the schizophrenic patients with neuroleptic-induced tardive dyskinesia.

Method: This randomized, rater-blind, parallel group, flexible dose study enrolled patients from Taoyuan Mental Hospital from July 2000 to December 2003. Schizophrenia, schizophreniform or schizoaffective disorder (DSM-IV) patients who met the research criteria of neuroleptic-induced tardive dyskinesia research criteria of DSM-IV and no less than moderate severity (\> or =4) of global impression of extrapyramidal syndrome rating scale (ESRS). 60 patients were random assignment to risperidone or olanzapine for 24 weeks. The primary outcome was to compare the change of total scores of abnormal involuntary movement scale from baseline to study endpoint.
All children were treated with antibiotics according to WHO classification and treatment of childhood pneumonia at health facilities 2012 \[18\], at enrollment after obtaining consent from parents and completing the baseline assessment, children were given a single injection of one ml of 100.000 IU of vitamin D3 (Cholecalciferol), vitamin D3 obtained from 2 ml vials containing 200,000 IU each (Devarol- S- 200.000 I.U. produced by Memphis for Pharmaceutical and Chemical Industries) and stored in manufacturer's recommended conditions in a dry, cool environment for 1-16 weeks (depending on the date of recruitment) . Syringes were labeled with a unique ID number and given by the blinded doctors choosing the next syringe with a randomization code.
PROBLEM TO BE SOLVED: To provide a culture method of Langerhans' islet capable of obtaining a sufficient amount of a transplant and an autotransplant. SOLUTION: Langerhans' islet is cultured in a culture blood serum (rat/ human) medium in which a radical scavenger, a growth factor, a matrix material, a nerve growth factor, a cell migration/scattering factor and anti-integrin β-1 antibody are added in a culture process. At first, the medium is added with the radical scavenger and the growth factor, then cultured for about 12-24 h, and next, the matrix material, the radical scavenger, the nerve growth factor and a growth factor are supplemented. At 4-5 days during the culture process, the growth factor, the cell migration/scattering factor and the anti-integrin β-1 antibody are supplemented. The culture process is continued for a long period of time so as every latent erythrocytes to be eliminated from the Langerhans' islet.  The growth is continued for a long period of time for producing the islet in an amount sufficient to transplant for regenerating the islet for completely curing the patients with diabetes mellitus until showing normal blood glucose while not containing fibroblast.
Patients who were admitted to the Cardiology Outpatient Clinic of Y State Hospital and passed the 6MWT conducted by the cardiology physician were eligible for participation in the green walk group. Following the physician's examination at the Cardiology Outpatient Clinic, the researcher conducted face-to-face interviews with the patients in a private room. During these interviews, the patients were administered the Structured Patient Information Form, Blood Lipids and BMI Monitoring Form, the Brief IPQ, and the MIDAS, and the collected data were recorded on the respective forms. Then, the researcher provided detailed information to the patients about green walking. For the randomized MI patients, two groups were formed, and they engaged in a 50-minute green walking three days a week for 12 weeks, under the guidance of the researcher. The green walk group's walks were scheduled differently for the two subgroups.
<P>PROBLEM TO BE SOLVED: To provide an ameliorating agent for muscle fatigue and an external preparation ameliorating various symptoms of the muscle fatigue such as stiffness of shoulders, neck pain and lumbago.  <P>SOLUTION: It is found that plant extracts having promoting actions on the production of β-endorphin, e.g. Helichrysum italicum, Crithmum maritimum, Lavandula stoechas, Cistus monspeliensis and Ulex europaeus have effects on amelioration of the stiffness of the shoulders and effects on the amelioration of myalgia. Furthermore, the effects are not only reduction of a sense of the muscle ache but also suppression of excessive contraction of the muscle and recovery from the fatigue. Thereby, an achievement is accomplished.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Abrupt discontinuation or dosage reduction of tranylcypromine tablets has been associated with the appearance of new symptoms that include dizziness, nausea, headache, irritability, insomnia, diarrhea, anxiety, fatigue, abnormal dreams, and hyperhidrosis. In general, discontinuation events occurred more frequently with longer duration of therapy.

There have been spontaneous reports of adverse reactions occurring upon discontinuation of MAOIs, particularly when abrupt, including dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g. paresthesia, such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures. While these reactions are generally self-limiting, there have been reports of prolonged discontinuation symptoms.

Patients should be monitored for these symptoms when discontinuing treatment with tranylcypromine tablets. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible [see Dosage and Administration (2.3) and Adverse Reactions (6)].
### Pregnancy Category C

The incidence of malformations was not increased compared to control in offspring of rats or rabbits given doses up to 13.9 times (rat) and 4.2 times (rabbit) the human daily dose on a mg/kg basis, or 3 times (rat) and less than 2 times (rabbit) the human daily dose on a mg/m2 basis. However, in rats, there was a decrease in pup weight and an increase in pup deaths during lactation. The cause for these deaths is not known. The no effect dose for rat pup mortality was 6.9 times the human dose on a mg/kg basis or 1.5 times the human dose on a mg/m2 basis.

Placental transfer of felbamate occurs in rat pups. There are, however, no studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

To provide information regarding the effects of in utero exposure to felbamate, physicians are advised to recommend that pregnant patients taking felbamate enroll in the NAAED Pregnancy Registry. This can be done by calling the toll free number 1-888-233-2334, and must be done by patients themselves. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/.
Recording of gastric motility with the investigational medical device. Gastric emptying rate of a liquid meal is assessed with the 13C-octanoate breath test.
Cosmetic use of Scutellariaextract as slimming agent for topical application. An independent claim is included for a cosmetic process to prevent and/or treat a degradation in the skin surface mainly on fat storage zones, comprising topical application of a cosmetic composition comprising the Scutellariaextract . ACTIVITY : Dermatological; Antiinflammatory; Antibacterial. MECHANISM OF ACTION : Lipolysis activator; Adipocyte dedifferentiation stimulator; Lipogenesis inhibitor; Adipocyte conversion inhibitor. The ability of the Scutellariaextract to inhibit adipocyte conversion was tested. The results showed that the treatment of the pre-adipocytary cells by the Scutellariaextract very strongly inhibited the triglycerides conversion process i.e. 66% inhibition on the eleventh day of application, thus the Scutellariaextract exhibited good inhibiting effect on adipocyte conversion and lipogenesis.
PROBLEM TO BE SOLVED: To prepare the subject color material including covered pigment with alkyl-modified silicone resin and having improved dispersibility of pigment in a nail varnish through using the pigment subjected to the treatment for inhibiting aggregation. SOLUTION: This color material comprises covered pigment in which at least part of pigment is covered with an alkyl-modified silicone resin. The covered pigment is prepared by covering pigment with silicone polymer coat having at least one of Si-H group and by adding a compound reactive with the Si-H group to the Si-H group so as for the pigment to support the silicone coat having an alkyl group from the compound virtually on the whole surface of the pigment. Inorganic pigment (e.g. titanium oxide, zinc oxide, etc.), a filmforming ingredient (e.g. nitrocellulose), a resin (e.g. alkyd resin), a plasticizer (e.g. castor oil), etc. are necessary for forming the covered pigment.
N6-methyladenosine (m6A) is the most abundant modification controlling RNA metabolism and cellular functions, but its roles in placental development are still poorly understood. Here, we characterized the synchronization of m6A modifications and placental functions by mapping the m6A methylome in human placentas (n = 3, each trimester), revealing that the dynamic patterns of m6A were associated with gene expression homeostasis and different biological pathways in placental development. Then, we generated trophoblast-specific knockout mice of Wtap, a critical component of methyltransferase complex, and demonstrated that Wtap was essential for trophoblast proliferation, placentation and perinatal growth. Further in vitro experiments which includes cell viability assays and series molecular binding assays demonstrated that WTAP-m6A-IGF2BP3 axis regulated the RNA stability and translation of Anillin (ANLN) and VEGFA, promoting trophoblast proliferation and secretion. Dysregulation of this regulatory axis was observed in placentas from pregnancies with fetal growth restriction (FGR) or preeclampsia, revealing the pathogenic effects of imbalanced m6A modifications. Therefore, our findings provide novel insights into the functions and regulatory mechanisms of m6A modifications in placental development and placental-related gestational diseases.
PURPOSE:To provide the subject new factor originated from the peripheral blood of a patient of chronic rheumatism, effective in clarifying the mechanism of systemic tissue disorder in chronic rheumatism and useful as a treating agent or diagnostic for systemic tissue disorder in chronic rheumatism. CONSTITUTION:The objective factor is derived from a fraction having a molecular weight of 900kd by gel-filtration fractionation method. It inhibits the DNA synthesis of normal peripheral blood monocyte and non-specifically damages the normal peripheral blood monocyte and human cell strain. It is stable to the heat-treatment at 56 deg.C for 30min or at 85 deg.C for 5min and is free from protease activity and collagenase activity. The factor can be prepared e.g. by collecting and clotting the peripheral blood of a patient of chronic rheumatism, separating the blood serum by centrifugal precipitation, fractionating the serum by high-performance liquid chromatography, etc., concentrating the obtained fraction having a molecular weight of 900kd by ammonium sulfate precipitation, etc., dialyzing with PBS and purifying the obtained crude product by ion-exchange chromatography.