anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: pigmented villonodular synovitis (PVNS) is a benign condition that affects the knee, leading to abnormal proliferation of the synovial membrane and the accumulation of hemosiderin in the joint cavity. Although it can be surgically treated, PVNS tends to have a high recurrence rate, potentially resulting in chronic joint damage.
CASE REPORT: we present the case of a young woman who experienced localized pain in her right knee due to a recurrence of PVNS. Magnetic resonance imaging revealed multiple multilobulated cystic lesions affecting the entire joint, including the ligaments. The patient underwent open surgical resection with a favorable clinical outcome. Histopathological examinations confirmed the absence of malignancy.
CONCLUSION: while arthroscopy is typically the preferred treatment for PVNS, this case highlights the tendency for recurrence associated with this approach. Open surgical resection, supported by benign histopathological findings in this case, suggests a favorable long-term prognosis.
BACKGROUND: Risk factors for local recurrence in patients with metastatic spinal cord compression (MSCC) has not been clearly investigated. So, the purpose of this study was to identify risk factors causing local recurrence following surgeries in patients with MSCC.
METHODS: We conducted a retrospective comparative study on 304 patients who underwent surgery for MSCC between March 2014 and February 2020. Local recurrence rate (LRR) was analyzed according to demographic variables, radiological variables such as level of spinal metastasis, number of non-spinal bone metastases, degree of spinal cord compression, spinal instability, and pathological fracture, and treatment-related variables such as origin of tumor, surgical treatment methods, and pre- and post- operative radiation therapy. Univariate and multivariate logistic regression analyses were performed to reveal the risk factors for local recurrence.
RESULTS: Among 304 patients with MSCC, 50 patients (16.4%) experienced local recurrence after surgery. Of the surgical methods, decompression alone (26/50, 52.0%) showed higher LRR compared to decompression with fixation (9/177, 5.1%) or corpectomy (11/89, 12.4%), (P = 0.002 and P = 0.018, respectively). Patients with renal cell carcinoma revealed higher LRR compared to other types (P = 0.014). It was found that the 3 or more level of spinal metastasis (P = 0.001), the 3 or more of extraspinal bone metastases (P = 0.028), and pathologic fracture (P = 0.003) were related with higher LRR. Smoking is also an independent risk factor for local recurrence in patients who underwent fixation (P = 0.026).
CONCLUSIONS: Symptomatic local recurrence may be influenced by several factors, including the extent of spinal and extraspinal bone metastasis, pathologic fractures, surgical approach, and tumor origin (RCC). These factors should be carefully considered by surgeons when evaluating the risk of symptomatic local recurrence after surgery.
Both exercise and metformin are common effective clinical treatments of type 2 diabetic mellitus. This study investigated the functional role of exercise, metformin, and combination treatment on type 2 diabetic mellitus-induced muscle atrophy. In this experiment, a total of 10 BKS mice were set as the control group. A total of 40 BKS-db/db mice were randomly divided into the control group (db/db); the exercise intervention group (db/db + Ex), which ran on a treadmill at 7-12 m/min, 30-40 min/day, 5 days/week; the metformin administration group (db/db + Met), which was administered 300 mg/kg of metformin solution by gavage daily; and the exercise combined with metformin administration group (db/db + Ex + Met). After 8 weeks of intervention, their tibialis anterior muscles were removed. The levels of insulin signaling pathway proteins, ubiquitin proteasome, and autophagic lysosome-associated proteins were detected using western blot, the expression of MuRF1 and Atrogin-1 was detected using immunohistochemical staining, and the degradation of autophagosomes was detected using double-labeled immunofluorescence. The db/db mice exhibited reduced insulin sensitivity and inhibition of the autophagic-lysosome system, the ubiquitin-proteasome system was activated, and protein degradation was exacerbated, leading to skeletal muscle atrophy. Exercise and metformin and their combined interventions can increase insulin sensitivity, whereas exercise alone showed more effective in inhibiting the ubiquitin-proteasome system, improving autophagy levels, and alleviating skeletal muscle atrophy. Compared with metformin, exercise demonstrated superior improvement of muscle atrophy by promoting the synthesis and degradation of autophagy through the AMPK/ULK1 pathway. However, the combination treatment exhibits no synergistic effect on muscle atrophy.
Patients receive paclitaxel IV over 3 hours followed by intraperitoneal carboplatin over 15 minutes on day 1 in course 1. Beginning in course 2, patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
The invention discloses pharmaceutical calcium folinate composition capsules for treating leucopenia and belongs to the technical field of medicines. The pharmaceutical calcium folinate composition capsules are prepared from calcium folinate, starch, microcrystalline cellulose, stearyl alcohol sodium sulfonate, povidone K30, 95% ethyl alcohol and talcum powder. The calcium folinate is a novel crystal-form compound and is different from calcium folinate in the prior art, as shown in Figure 1 of an X-ray powder diffraction diagram obtained through Cu-KAlpha ray measurement. A test shows that the calcium folinate crystal-form compound is good in stability and low in impurity content compared with the prior art. The solubility and liquidity in water of the crystal-form compound are obviously improved compared with the prior art, the problems of poor water solubility, poor stability and high related substance content of the calcium folinate in the prior art are solved, convenience is brought to preparation of preparations, and the pharmaceutical effect is also greatly improved. The capsules prepared by using the novel crystal-form compound are high in dissolution rate, good in stability and high in bioavailability and are very suitable for clinic application.
This disclosure relates generally to the field of taxonomic profiling of microbial organisms such as bacteria, and, more particularly, to system and method for simultaneous interpretation of taxonomic distribution and replication rates of microbes constituting microbial communities. The present disclosure extracts bacterial genomic DNA from a plurality of bacterial organisms comprised in collected microbiome sample. Maps the plurality of the DNA sequence fragment reads to a precomputed reference sequence database of a plurality of all available completely sequenced bacterial genomes. Based on the mapping, the read coverage is measured at the genomic locations of the phylogenetic marker genes, wherein measured read coverage is used for interpretation of taxonomic distribution of the plurality of bacterial organisms. A plurality of slopes is obtained by fitting a linear function. The present disclosure interprets a replication rate for each of the plurality of bacterial organisms identified from the collected microbiome sample.
All children with CMN that will have their nevus removed in our surgical department will be asked to participate. The investigators will send a package of questionnaires to evaluate quality of life and stigmatization before nevus surgery. One year after surgical therapy is finished (sometimes more then one session is necessary), the scar will be clinically evaluated and also another questionnaire package will be sent to evaluate the same parameters again. All parameters are checked for the patients and the families as well. Therefore self and proxy reports of the parents are asked. Moreover, for the patients this is done with interviews in case they are older than 7 years.
As with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated. Cross-sensitivity to other aminoglycoside antibiotics may occur; if hypersensitivity develops with this product, discontinue use and institute appropriate therapy. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis. 

Information for Patients: Do not touch dropper tip to any surface, as this may contaminate the solution. 

Pregnancy Category B: Reproduction studies in three types of animals at doses up to thirty-three times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and wellcontrolled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. 

Nursing Mothers: Because of the potential for adverse reactions in nursing infants from tobramycin, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother. 

Pediatric Use: Safety and effectiveness in pediatric patients below the age of two months has not been established. 

Geriatric Use: No overall clinical differences in safety or effectiveness have been observed between the elderly and other adult patients.
PURPOSE: A human cervical cancer 1(HCCR-1) gene and a protein coded thereby are provided for the prevention and treatment of various cancers. CONSTITUTION: The human cervical cancer 1(HCCR-1) gene as a protooncogene has the base sequence of sequence No. 1 consisting of 2118 bps, in which the base sequence from 9 to 1088 is an open reading frame which encodes a HCCR-1 protein having the amino acid sequence of sequence No. 2 consisting of 360 amino acids, wherein the amino acid sequence from 1 to 25 encodes signaling peptide, and the amino acid sequence from 435 to 494 encodes single transmembrane domain. A microorganism JM109/HCCR-1(KCTC 0667BP) is produced by the transformation of a HCCR-1 containing vector. The microorganism JM109/HCCR-1(KCTC 0667BP) produces the HCCR-1 protein. A HCCR-1 diagnosing kit article manufactured by using the HCCR-1 is used for diagnosing the infection of HCCR-1 and treating the human cervical cancer.
Men and women, 18 years of age and older. Asthmatic since at least one year before inclusion. Patient's informed consent obtained.
UNLABELLED: The role of recent fracture site in predicting the most detrimental subsequent fractures, hip and vertebral, is unclear. This study found that most recent fracture sites were associated with an increased risk of both hip and vertebral fracture, a finding that may impact the design of secondary prevention programs.
BACKGROUND: Hip and vertebral fractures are the most serious in terms of associated morbidity, mortality, and societal costs. There is limited evidence as to which fracture types are associated with the highest risk for subsequent hip and vertebral fractures. This study aims to explore the dependency of imminent hip and vertebral fracture risk on the site of the recent index fracture.
METHODS: Conducted as a nationwide retrospective cohort study, we utilized Swedish national registers to assess the risk of hip and vertebral fractures based on the site of the recent (≤ 2 years) index fracture and an old (> 2 years) prevalent fracture. This risk was compared to that observed in individuals without any prevalent fractures. This study encompassed all Swedes aged 50 years and older between 2007 and 2010. Patients with a recent fracture were categorized into specific groups based on the type of their previous fracture and were followed until December 2017, with censoring for death and migration. The study assessed the risk of hip and vertebral fractures during the follow-up period.
RESULTS: The study included a total of 3,423,320 individuals, comprising 145,780 with a recent fracture, 293,051 with an old fracture, and 2,984,489 without a previous fracture. The median follow-up times for the three groups were 7.6 years (IQR 4.0-9.1), 7.9 years (5.8-9.2), and 8.5 years (7.4-9.7), respectively. Patients with a recent fracture at almost all sites exhibited a significantly increased risk of hip fracture and an elevated risk of vertebral fracture compared to controls. Patients with recent fractures had an increased risk of subsequent hip and vertebral fractures, regardless of the index fracture site. These results strengthen the notion that all patients with a recent fracture, regardless of fracture site, should be included in secondary prevention programs, to improve the prevention of the clinically most serious fractures.
BACKGROUND: The occurrence of postoperative complications may affect short-term outcomes and prognosis of patients with various malignancies. However, the prognostic impact of these complications in older patients with colorectal cancer (CRC) remains unclear. Therefore, this study aimed to investigate the impact of severe postoperative complications on the oncological outcomes of older (aged ≥ 80 years) and non-older (aged < 80 years) patients with CRC.
METHODS: We retrospectively analyzed 760 patients with stage I-III CRC who underwent curative surgery in two institutions between 2013 and 2019. The patients were categorized into older (aged ≥ 80 years, 191 patients) and non-older (aged < 80 years, 569 patients) groups. Short- and long-term outcomes were compared between the two groups.
RESULTS: The incidence of severe postoperative complications did not differ between the two groups (p = 0.981). Cancer-specific survival (CSS) was significantly worse in older patients with severe complications than in those without severe complications (p = 0.007); meanwhile, CSS did not differ between the non-older patients with severe complications and those without severe complications. Survival analysis revealed that the occurrence of severe postoperative complications was an independent prognostic factor for CSS in older patients (hazard ratio = 4.00, 95% confidence interval: 1.27-12.6, p = 0.017).
CONCLUSION: CRC surgery can be safely performed in older and non-older patients. Moreover, the occurrence of severe postoperative complications might more strongly affect the prognosis of older patients than that of non-older patients.
Finely-divided inorganic materials are rendered water-repellent by exposure to the vapour of one or more organo-silicon halides, preferably a methyl silicon halide mixture containing an average of 1 to 3 methyl groups per silicon atom, particularly azeotropic mixtures of trimethyl-chlorosilane and silicon tetrachloride.  The materials may be fillers or pigments for paper, paints, lacquers, face powders or masking creams, e.g., oxides of lead, iron, titanium or zinc, carbonates of calcium and lead, calcium and barium sulphates, aluminium and magnesium silicate, cadmium chromate, zinc sulphide, clays.  Alkyl, aryl, alkaryl or aralkyl silicon halides may be used. In an example, "Catalpo" (Registered Trade Mark) clay thus treated, pasted with a water miscible liquid, e.g., acetone or alcohol, is beaten with wood pulp in water and the product made into paper.  The process improves compatibility, flow, covering power, fluffiness and thixotropy.  Specifications 572,740 and 575,696, [both in Group VIII], are referred to.ALSO:Finely divided inorganic materials are rendered water-repellent by exposure to the vapour of one or more organo silicon halides, preferably a methyl silicon halide mixture containing an average of 1 to 3 methyl groups per silicon atom, particularly azeotropic mixtures of trimethyl chlorsilane and silicon tetrachloride.  The materials may be fillers or pigments for moulded products, paints, paper, &c.  Alkyl, aryl, alkaryl or aralkyl silicon halides may be used.  A series of inorganic oxides and salts are specified.  In an example "Catalpo" (Registered Trade Mark) clay, thus treated, pasted with a water miscible liquid, e.g., acetone or alcohol, is beaten with wood-pulp in water and the product made into paper. The process improves compatibility, flow, covering power, fluffiness and thixotropy.  Specifications 572,740 and 575,696, [both in Group VIII], are referred to.ALSO:Finely - divided inorganic materials are rendered water-repellent by exposure to the vapour of one or more organo silicon halides, preferably a methyl silicon halide mixture containing an average of 1 to 3 methyl groups per silicon atom, particularly azeotropic mixtures of trimethyl chlorsilane and silicon tetrachloride.  The materials may be fillers or pigments for paints, lacquers, face powders or masking creams, e.g. oxides of lead, iron, titanium or zinc, carbonates of calcium and lead, calcium and barium sulphates, aluminium and magnesium silicate, cadmium chromate, zinc sulphide, clays.  Alkyl, aryl, alkaryl or aralkyl silicon halides may be used.  In an example, "Catalpo" (Registered Trade Mark) clay, thus treated and pasted with a water-miscible liquid, e.g. acetone or alcohol, is beaten with wood pulp in water and the product made into paper.  The process improves compatibility, flow, covering power and thixotropy. Specifications 572,740 and 575,696, [both in Group VIII], are referred to.
Considering that a multifactorial lifestyle approach may prove more effective than a single factor approach to improve or maintain brain health, we evaluated the association of exercise (open skill exercise [OSE] or closed skill exercise [CSE]) combined with long-chain polyunsaturated fatty acid (LCPUFAs) (docosahexaenoic acid [C22:6n-3, DHA], eicosapentaenoic acid [C20:5n-3, EPA], and arachidonic acid [C20:4n-6, ARA]) intake with brain atrophy among older Japanese individuals (n = 795, aged 60-88 years) without a self-reported history of dementia based on the datasets of a two-year longitudinal study. Brain volumes were measured using three-dimensional T1-weighted brain magnetic resonance imaging for follow-up periods of two years. The associations between multivariate-adjusted changes in brain volumes and OSE or CSE frequency (≥ once/month and < once/month) along with LCPUFA intake (≥ median and < median) at the baseline were assessed using a general linear model. Subgroup analysis was performed by restricting DHA and EPA intakes (n = 263; median, 323 mg/d), which represented levels similar to those in countries with low fish consumption. Higher OSE frequencies, ARA intakes, and their combination were inversely associated with decreases in total gray matter and frontal cortex volumes. In subgroup analysis, a combination of higher OSE frequencies and DHA intakes was also associated with a smaller decrease in total gray matter volume. Overall, our findings suggest that regular OSE engagement and appropriate LCPUFA intake may contribute to preventing brain volume decreases in older individuals.
Participants will receive IV infusion of MEDI-551 12 mg/kg on Days 1 and 8 of Cycle 1 and thereafter Day 1 of 28- day cycles from Cycle 2 onwards. Treatment will be continued until the participants experiences unacceptable toxicity, disease progression, reaches CR or withdraws consent.
No specific information on emergency treatment of overdosage with betaxolol tablets, USP is available. The most common effects expected are bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. In one acute overdosage of betaxolol, a 16-year-old female recovered fully after ingesting 460 mg.

Oral LD 50s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats. 

In the case of overdosage, treatment with betaxolol tablets, USP should be stopped and the patient carefully observed. Hemodialysis or peritoneal dialysis does not remove substantial amounts of the drug. In addition to gastric lavage, the following therapeutic measures are suggested if warranted:

Hypotension: Use sympathomimetic pressor drug therapy, such as dopamine, dobutamine, or norepinephrine. In refractory cases of overdosage of other beta-blockers, the use of glucagon hydrochloride has been reported to be useful. 

Bradycardia: Atropine should be administered. If there is no response to vagal blockade, isoproterenol should be administered cautiously (see Warnings: Major surgery). In refractory cases the use of a transvenous cardiac pacemaker may be considered. 

Acute cardiac failure: Conventional therapy including digitalis, diuretics, and oxygen should be instituted immediately. 

Bronchospasm: Use a ß 2\- agonist. Additional therapy with aminophylline may be considered. 

Heart block (2nd- or 3rd-degree): Use isoproterenol or a transvenous cardiac pacemaker.
PURPOSE:A drug for external use in inhibiting melanization, containing a blend of cyclodextrin with KOJIC acid, particularly KOJIC acid included with the cyclodextrin and used for external therapy for pigmentation, e.g. chloasma, etc. CONSTITUTION:A drug for external use containing a blend of cyclodextrin, preferably alpha,beta,gamma-cyclodextrin, methylcyclodextrin, particularly preferably beta- cyclodextrin with KOJIC acid (a compound obtained from a bacterium, e.g. the genus Aspergillus, Gluconobacter, etc., and useful for inhibiting melanization. The amounts of the KOJIC acid and cyclodextrin are 1pt.wt. KOJIC acid and about 10-0.5pts.wt., particularly 4-5pts.wt. cyclodextrin. The blend of the cyclodextrin with the KOJIC acid is preferably the KOJIC acid included in the cyclodextrin.
Calcium acetate, USP acts as a phosphate binder. Its chemical name is Calcium acetate, USP. Its molecular formula is C 4H 6CaO 4, and its molecular weight is 158.17. Its structural formula is: 

Each opaque capsule with a blue cap and white body is spin printed in blue and white ink with “SUVEN” printed on the cap and “667” printed on the body. Each capsule contains 667 mg calcium acetate, USP (anhydrous; Ca(CH 3COO) 2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, and water as the inert binder, crospovidone and sodium stearyl fumarate . The gelatin cap and body have the following inactive ingredients: FD&C blue 1, D&C red 28, titanium dioxide and gelatin. Imprinting ink on capsule body contains shellac and FD&C 2 Aluminum Lake and imprinting ink on capsule cap contains shellac, titanium dioxide and potassium hydroxide. Calcium acetate capsules are administered orally for the control of hyperphosphatemia in end-stage renal failure. Meets USP Dissolution Test 4