anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of this paper is to present the surgical technique of selective Bowman's layer transplantation as well as the results of the surgery in patients with trophic corneal ulcers. The methodology of the study included three eyes from three patients with neurotrophic corneal ulcers grafting with corneal Bowman's layer. Pre- and postoperative analyses of the anterior segment of the eye were based on optical coherence tomography and slit-lamp assessment. Postoperatively a gradual corneal stroma restoration and fast corneal epithelialization were noticed. Based on our observations, the stiff and firm structure of Bowman's layer is supposed to strengthen the corneal surface and maintain its shape. It acts also as an antipathogen and antitoxin corneal barrier. Application of this acellular corneal layer transplantation to cover trophic corneal ulcers is an interesting, modern and crucial method of neurotrophic keratitis treatment.
PURPOSE: To identify sociodemographic factors associated with HPV vaccine uptake in a universal, in-school HPV vaccination program, among grade 6 and 9 students in the regional health authority of Vancouver Coastal Health (VCH), British Columbia (BC), Canada during the 2021/22 school year. VCH operates within the southwest corner of the province of BC serving a mix of urban and rural regions. HPV vaccine is offered in school to all grade 6 students using a two-dose series, with catch up immunizations offered to students in grade 9.
METHODS: We conducted a cross-sectional study of grade 6 and 9 students enrolled in VCH schools for the 2021/22 school year, who also resided within the VCH region. We modelled the associations between sociodemographic explanatory variables (individual-level and group-level) and fully vaccinated outcome using a cross-classified (non-nested) multilevel model.
RESULTS: Among the 17,939 students eligible, 74 % were fully vaccinated for HPV. Immunization coverage was associated with grade, geographic area of residence, school category, social and material deprivation. We demonstrated that grade modified the association between material deprivation and being fully vaccinated. Grade 9 students, including those residing in more materially deprived neighbourhoods, had substantially higher odds (OR 2.01 [95 % CI 1.08, 3.75]) of being fully vaccinated relative to grade 6 students in the least materially deprived neighbourhoods.
CONCLUSIONS: Though publicly funded HPV vaccine is offered to all students in grade 6 and 9, in a space that maximizes programmatic access, sociodemographic factors associated with under-immunized populations were identified. This information can be leveraged for strategic targeting of resources to underimmunized schools or students to mitigate impacts. The repeat offering of HPV vaccine in an older grade (grade 9 in BC) is a key programmatic strategy to reach under-immunized populations and should be complemented by other creative approaches.
The invention relates to means and methods of producing at least two antibodies. Methods may include providing cells with nucleic acid that encodes the antibodies; culturing said cells; collecting the antibodies from the culture; and separating produced antibodies from half antibodies by ion exchange chromatography (IEX). In some embodiments the antibodies exhibit IEX retention times that that deviate by 10% or less from the average of the retention times of the individual antibodies under the IEX conditions used. The invention also relates to compositions of antibodies thus produced. In some aspects the invention relates to compositions comprising 2-10 recombinant antibodies characterized in that the IEX retention times of at least two of said antibodies deviate by 10% or less from the average of the retention times of the individual antibodies under the IEX conditions. It also relates to compositions comprising 2-10 recombinant antibodies characterized in that the pI of at least two of said antibodies differ by 0.4 units or less from the average pI of said at least two antibodies.
This study will be a single-centred, open-label, prospective randomized controlled study to compare the extent of OA-related knee pain relief between subjects who undergo radiofrequency lesioning (COOLIEF\* CRFA; Avanos Medical) of the genicular nerves and subjects who receive a single intra-articular HA injection (Synvisc-One \[Hylan G-F 20\]; Sanofi). Study subjects will receive CRFA or HA injection in a 1:1 randomization scheme, with post-treatment data collection at 2 weeks, 1 month, 3 months and 6 months. Six months was chosen as the duration of follow-up as that is the expected duration of medical improvement following HA injection for chronic knee pain. Knee pain, function, overall subject impressions of treatment, quality of life, pain medication use, and adverse events will be compared among the treatment cohorts. The study is open-label as blinding is not possible due to the differences in administration of injection and CRFA, hence both the patient and the investigator will be aware of the treatment type.

The primary endpoints will be the extent of reduction of pain score measured via 11-point visual analogue scale (VAS). Secondary outcomes will include proportion of subjects ("responders") whose knee pain is reduced by at least 50% from baseline up to 6 months after treatment, patients' overall knee pain score as measured via Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), subjects' perception of treatment effect as measured via Knee injury and Osteoarthritis Outcome Score (KOOS), patients' perception of treatment effect via Global Perceived Effect (GPE) score and health related quality of life via EuroQol-5 Dimensions 5 Level (EQ-5D-5L). Assessments of these study endpoints will be made at baseline, 2 weeks, 1 month, 3 months and 6 months following treatment.
Time-limited (18 or 24 months) intervention program for children (aged 5-12) with neuropsychiatric/psychiatric disorder(s). Etä-LAKU family program (18 months) includes 35 family-based meetings and two separate family weekends. A 24-month-program will include 10 additional family-based meetings.
Sarcopenia, a decline in muscle mass and strength, can be triggered by aging or medications like glucocorticoids. This study investigated cornflower (Centaurea cyanus) water extract (CC) as a potential protective agent against DEX-induced muscle wasting in vitro and in vivo. CC and its isolated compounds mitigated oxidative stress, promoted myofiber growth, and boosted ATP production in C2C12 myotubes. Mechanistically, CC reduced protein degradation markers, increased mitochondrial content, and activated protein synthesis signaling. Docking analysis suggested cannabinoid receptors (CB) 1 and 2 as potential targets of CC compounds. Specifically, graveobioside A from CC inhibited CB1 and upregulated CB2, subsequently stimulating protein synthesis and suppressing degradation. In vivo, CC treatment attenuated DEX-induced muscle wasting, as evidenced by enhanced grip strength, exercise performance, and modulation of muscle gene expression related to differentiation, protein turnover, and exercise performance. Moreover, CC enriched gut microbial diversity, and the abundance of Clostridium sensu stricto 1 positively correlated with muscle mass. These findings suggest a multifaceted mode of action for CC: (1) direct modulation of the muscle cannabinoid receptor system favoring anabolic processes and (2) indirect modulation of muscle health through the gut microbiome. Overall, CC presents a promising therapeutic strategy for preventing and treating muscle atrophy.
1,132,031. Furnace tube walls; finned tubes. PROVINCIAAL EN GEMEENTELIJK UTRECHTS STROOMLEVERINGS - BEDRIJF N.V. 15 Feb., 1966 [19 Feb., 1965], No. 6569/66. Headings F4B and F4S. [Also in Division B3] Heat exchange tubes for cooling furnace walls and supporting a refractory lining are provided with studs extending from the tube wall and attached thereto by welding, each stud comprising a core of carbon steel, around which is a jacket of steel with a chromium content of at least 12%. The core steel may contain traces of chromium and/or aluminium and/or silicon, and the jacket may also contain aluminium and/or silicon, The jacket is formed by deposition of chromium from a chromium-containing atmosphere, which may also contain aluminium and/or silicon. A rod may be subjected to this treatment and then cut in two to form two studs.
Introduction: The association between unintentional weight loss (WL) and outcomes after major hepatectomy for malignancy remains unclear.Methods: This retrospective cohort study reviewed the 2014-2019 NSQIP database of all patients who underwent major liver resections. The patients were categorized into two groups based on their history of weight loss. The primary outcome measure was the 30-day mortality. The secondary outcome was 30-day in-hospital complications.Results: In total, 384 patients had a history of preoperative weight loss. Preoperative WL was an independent predictor of septic shock (OR, 2.44; CI: 1.61, 3.69), bile leak (OR: 1.96; CI: 1.51, 2.55), and grade C liver failure (OR: 2.57; CI: 1.64, 4.01). However, preoperative WL was not a significant predictor of perioperative mortality (OR: 1.38; CI: 0.82, 2.32).Conclusion: The study found higher morbidity rates in patients undergoing liver resection with a history of weight loss. Further validation with prospective weight monitoring is needed to validate as a prognostic marker in patients undergoing hepatectomy. In addition, weight changes can help guide multidisciplinary decision-making in treating patients undergoing hepatectomy.
Intervention treated wounds in Group A participants will be covered using the exciflex bandage which will be activated to deliver ES using a 10% duty cycle, i.e. ES will be active for 1 minute out of every 10 minutes. ES will be delivered for up to 10 weeks or until the wound is healed for 3 days. The exciflex bandage will be changed when indicated clinically or every 5 days, whichever is sooner. At each bandage change, wound status monitored as described above, specifically a 3D digital image and wound swabs will be obtained. The exciflex power/control module will then be transferred to a new sterile flexible substrate and the exciflex bandage reapplied to the wound.
The invention comprises quinolines which contain in the 3-position an unsubstituted or substituted guanidino group and which are unsubstituted or C-substituted by a lower alkyl or a lower alkoxy or an alkylene dioxy group, their physiologically tolerable acid addition salts, acyl derivatives and quaternary ammonium salts, pharmaceutical preparations containing these compounds (see Group VI)., and the preparation of the compounds by reacting a 3-aminoquinoline with an S-alkylisothiourea or a cyanamide and, if desired, in a resulting quinolyl-(3)-guanidine whose imino or amino groups are unsubstituted, substituting the latter by hydrocarbon radicals or acyl radicals and/or converting the resulting free compound into a salt or a salt into the free compound.  Substituents of the guanido group include alkyl, alkylene (in which instance when the alkylene group is ethylene the guanido group is a 4,5-dihydroimidazoyl-(2)-amino group) and acyl groups.  Acyl groups are derived from acids such as lower alkoxy carbonic, carbamic, lower alkanoic, lower alkenoic, lower alkynoic, b -cyclopentylpropionic, monohaloacetic, trifluoracetic, methoxy acetic, dimethylaminoacetic, b -dimethylaminopropionic, b -piperidinopropionic, benzoic, methoxybenzoic, 3,4,5-trimethoxybenzoic, 4-O-ethoxysyringic, 3,4-dichlorobenzoic, 3-nitrobenzoic, 3 dimethylaminobenzoic, nicotinic, isonicotinic, 2-furancarboxylic, 2-thiophenecarboxylic, phenyl- or diphenyl-acetic, b -phenylpropionic, p-methoxyphenylacetic, cinnamic, p-chlorocinnamic, 3,4,5-trimethoxycinnamic, pyridyl-(2)-acetic and thienyl-(2)-acetic acids.  Lower alkyl and alkoxy groups contain 1 and 7 carbon atoms.ALSO:Pharmaceutical compositions having anti-hypertensive activity comprise quinolines substituted in the 3 position by guanidino groups and optionally C-substituted by lower alkyl or lower alkoxy groups (i.e. containing 1-7 carbon atoms), their acyl derivatives, acid addition or quaternary ammonium salts and a pharmaceutical carrier.  The guanidino groups may be unsubstituted or substituted by alkyl or alkylene groups (in which latter instance the guanidino group is converted into a heterocyclic ring e.g. a - 4 : 5 - dihydro - imidazolyl - (2) - amino group with ethylene).  Acyl derivatives are derived from aliphatic, monocyclic aromatic, heterocyclic araliphatic or heterocyclic-aliphatic carboxylic acids, salts from therapeutically useful organic and inorganic acids and quaternary ammonium salts from reactive esters of alkanols or aralkanols. The compositions are in a form suitable for enteral or parenteral administration such as tablets, dragees, capsules, solutions, suspensions or emulsions and may contain other therapeutically useful substances.
Hyperemesis gravidarum has a reported incidence of approximately 0.3-3% of pregnancies. Without treatment, refractory hyperemesis gravidarum can result in dehydration, electrolyte deficiencies, and severe nutritional deficiencies, resulting in significant maternal morbidity. The overall goals of inpatient management of refractory hyperemesis gravidarum are the resumption of oral intake to an adequate level to maintain hydration and nutrition, including the ability to tolerate oral pharmacotherapy. Patients initially are stabilized with rehydration and electrolyte repletion. There are numerous pharmacotherapeutics available that can be administered intravenously to control symptoms when oral intake is not an option. However, despite maximizing typical antiemetics, there will be cases refractory to these medications, and alternative pharmacotherapeutics and nutrition-support modalities must be considered. Mirtazapine, olanzapine, corticosteroids, and gabapentin are examples of alternative pharmacotherapeutics, and enteral and parenteral nutrition are alternative therapies that can be used when oral intake is not tolerated for prolonged time periods with ongoing weight loss. In refractory cases of hyperemesis gravidarum, the risks and benefits of these alternative forms of management must be considered, along with the risks of undertreated hyperemesis gravidarum and the overall effect of hyperemesis gravidarum on patients' quality of life.
C20T5 Ruby CBD Oil (Cannatrek Ltd, Australia). 20mg/ml CBD and 5mg/ml THC in sunflower oil.
A system and method are provided for generating a predictive model for use in optimizing a clinical workflow. The predictive model may be generated as follows. Workflow metadata is obtained which is indicative of the clinical workflow. A viewer log is obtained of an image viewer used by a physician to review one or more medical images. The viewer log may be indicative of one or more viewing actions performed by the physician using the image viewer. A diagnostic value of the one or more medical images is then estimated based on the viewing actions. The above steps are performed for different clinical workflows. A machine learning technique is then applied to the resulting plurality of diagnostic values and plurality of workflow metadata to generate the predictive model. The generated predictive model is predictive of the diagnostic value of medical images acquired by a particular clinical workflow given the workflow metadata of the particular clinical workflow. Advantageously, the predictive model can be used to modify the clinical workflow so as to increase the diagnostic value of the acquired images.
Maigne's thoracic pain is a condition in which pain originates from the thoracic spine, but according to Maigne, in most cases, its origin lies in the lower three cervical segments. It is common among both men and women, but it is most common among women. Common symptoms of Maigne's thoracic pain are tenderness and stiffness of thoracic muscles, especially interscapular muscles. The most important and chief complaint reported by patients of this condition is unilateral and severe pain which increases with static sitting and with carrying or lifting heavyweight. Physical examination of tenderness on the interscapular region at the level of T5-T6, 1-2 cm lateral to the midline. Pressure reproduces the patient's pain. Several clinical trials have established therapeutic guidelines and protocols for the rehabilitation of hyperkyphosis. These trials have typically focused on the use of spinal bracing, therapeutic taping, manual therapy, and therapeutic exercise for postural training. Studies have been conducted on the effectiveness of combination therapy of thoracic extension exercises with other therapeutic exercises. Similarly, many studies have been conducted on thoracic stabilization exercises for posture correction. It is quite difficult to judge which exercise is more effective than the other. Moreover, typically for the management of Maigne's Thoracic pain, the efficacy of therapeutic treatment is quite underexplored. The rationale of this study is that it will provide evidence that may improve treatment strategies for the management of Maigne's Thoracic pain, majorly focusing on the muscular component of the thoracic region.
The invention relates to the technical field of genetic engineering, in particular to a pEGFP-N1/SEPT8 eukaryotic expression vector, a construction method, a SEPT8 gene interference fragment and application. The sequence of the pEGFP-N1/SEPT8 eukaryotic expression vector has a sequence shown in SEQ ID NO. 1. The construction method of the pEGFP-N1/SEPT8 eukaryotic expression vector has the advantages of simple operation and low operation difficulty. siRNA interfering fragment of SEPT8 gene, including four siRNA1, siRNA2, siRNA3 and siRNA 4. The siRNA interference fragment of SEPT8 gene has profound development value in preparing the application for inhibiting tumor cell migration and invasion.
All participants will be assigned to one of up to 87 peer coaches, who also are Detroit VA diabetes patients who previously had poor glycemic control but are currently in good control. After their baseline assessment, participants in both arms will receive information on their lab and blood pressure values and will be randomized to one of the two study arms. Participants in the TEC arm will be scheduled for an initial visit with their coach to review the decision aid, which has incorporated their personal baseline data.
Urolithiasis is a high‑incidence disease caused by calcium oxalate (mainly), uric acid, calcium phosphate, struvite, apatite, cystine and other stones. The development of kidney stones is closely related to renal tubule cell damage and crystal adhesion and aggregation. Cell death, comprising the core steps of cell damage, can be classified into various types (i.e., apoptosis, ferroptosis, necroptosis and pyroptosis). Different crystal types, concentrations, morphologies and sizes cause tubular cell damage via the regulation of different forms of cell death. Oxidative stress caused by high oxalate or crystal concentrations is considered to be a precursor to a variety of types of cell death. In addition, complex crosstalk exists among numerous signaling pathways and their key molecules in various types of cell death. Urolithiasis is considered a metabolic disorder, and tricarboxylic acid cycle‑related molecules, such as citrate and succinate, are closely related to cell death and the inhibition of stone development. However, a literature review of the associations between kidney stone development, metabolism and various types of cell death is currently lacking, at least to the best of our knowledge. Thus, the present review summarizes the major advances in the understanding of regulated cell death and urolithiasis progression.
Low back pain (LBP) is a significant health problem internationally characterized by various biophysical, psychological, and social dimensions affecting functioning, societal participation, and personal financial prosperity.The reported prevalence of LBP was high, especially for chronic non-specific low back pain, approximately 15.4%. of which chronic low back pain was about 2.5 times more prevalent in the working population compared to the non-working group. Recently, there has been a focus on lumbar stabilization exercises that prove to be effective and may be superior to general exercises for LBP management. The approach is aimed at improving the neuromuscular control, strength, and endurance of the active subsystem stabilizing the spine. Several groups of muscles are particularly targeted namely, the transverses abdominis and the multifidus muscles that are central to maintain spinal and trunk stability. But also other core muscles are involved. so this study will be conducted to investigate the effect of segmental stabilization exercise on low back pain. forty-five patients will be allocated to three groups. first experimental will receive segmental stabilization phase 1 and phase 2, second experimental will receive segmental stabilization phase 1 and 3, the third one is the control group and receives traditional treatment
Patients with late staged and/or recurrent sarcoma have poor prognosis despite complex multimodal therapy. Therefore, innovative interventions are needed. Sarcoma is known to express increased levels of surface antigens that can be targeted by CAR-T cells. In addition, studies have shown that low dose chemotherapy such as doxorubicin may modulate surface PD-L1 level and enhance immunotherapy effects. This study will combine multiple CAR T cells with low dose chemotherapy to treat sarcoma, and followed by maintenance sarcoma vaccines. The purpose of this clinical trial will assess the feasibility, safety, efficacy and side effects of this combination therapy in patients who have sarcoma that is relapsed or late staged.
SIBS intervention is a 5-session group intervention for siblings and parents of children with chronic illness. Sessions 1-3 are delivered in one day, and sessions 4-5 are delivered in one day one week later.
FIELD: molecular biology. SUBSTANCE: invention finds nucleotide sequence of synthetic gene for plant toxin gelonine and a method of preparing, cloning and expression of this synthetic gene. DNA sequence for gelonine synthetic gene is given as sequence ID N 1. Invention proposes also expression vectors containing DNA sequences for gelonine and cells transformed with these vectors. Also, immunotoxin containing antibodies conjugated with protein gelonine is proposed. EFFECT: improved method of procedures.
The invention relates to a medical prescription and a preparation method of catalpol-puerarin freeze-dried powder injection. The invention is characterized in that the medical prescription of the catalpol-puerarin freeze-dried powder injection comprises 1 to 1000mg of catalpol, 1 to 3000mg of puerarin, 100 to 8000mg of mannite, 50 to 4000mg of fucose as well as proper amount of 50% propanediol. The freeze-dried powder injection prepared by catalpol and puerarin has medical application in the treatment of clinic cerebral ischemic diseases. The invention also comprises the adjuvant used in the medical prescription for preparing the freeze-dried powder injection of the composition prepared by catalpol, puerarin and other drugs according to different mixture ratio to cure the ischemic diseases. The invention aims at providing the compound drug preparation of the active components of Chinese herbs for curing the ischemic diseases. The preparation can penetrate blood brain barriers, lighten the injury degree of cerebral ischemia, improve the durable capacity of ischemia and oxygen deficiency of brain tissues, promote the rebirthing and maturity of brain microvascular, protect the neurovascular units, promote the growth of neuron axon and neurodendrite, enhance the synaptic reorganization, improve the neurological behavior after cerebral ischemia, increase the neurological scores and promote the motor function resuming of the tired limbs after the cerebral ischemia.