anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A dittany glycoside R and a preparation method and application thereof relate to a compound, a preparation method thereof and application of the compound. Dictamni glucoside R has molecular formula of C  21  H  36  O  9  The molecular weight is 432.2359. The preparation method comprises the following steps: 1. pulverizing cortex Dictamni Radicis, and extracting with 95% ethanol; 2. dispersing the ethanol-recovered extract with water, and sequentially extracting with petroleum ether, dichloromethane, ethyl acetate and n-butanol; 3. and (3) repeatedly performing silica gel column chromatography on the ethyl acetate extraction layer, and performing high performance liquid chromatography separation to obtain the monomer compound. The dittany glycoside R has in-vitro anti-tumor activity and is specific to MDA-MB-231 human breast cancer cell IC  50  The value was 60.5 (μg/ml) and the minimum effective concentration was 12.5 (μg/ml). Has strong inhibition on MDA-MB-231 human breast cancer cells. The invention belongs to the field of organic matter extraction.
The invention relates to a preparation technology and a production method of a novel dual-purpose decoction integrated dosage form. The novel dual-purpose decoction integrated dosage form consists of the following raw material active ingredients in parts by weight: 4.4 parts of cassia bark core, 4 parts of dried ginger, 30 parts of liquoric root and 4.4 parts of apricot kernel. The production process comprises ultrasonic speed fluid energy milling, alcohol-water extraction, ultrasonic wave smashing and extracting, water decoction concentration, ultrasonic speed spray drying, nanometer grinding, high-pressure homogenization, nanoparticle preparation and the like. In the invention, the advantages of multi-coordination, multi-targeting and the like represented in a nano-carrier coupling technique are utilized. After large-scale production is performed, the production cost can be reduced greatly, the product quality can be enhanced greatly, and the targeting property and controlled release property of a medicament can be enhanced. A dual-purpose decoction can be administrated internally and externally, and can be taken at four time intervals according to midnight-noon ebb-flow and the qi-blood flow rule of a human body. The dual-purpose decoction can be prepared into a film forming agent and a transdermal agent which are attached to different positions of a human body respectively according to midnight-noon ebb-flow and the qi-blood flow rule of the human body and can be directly absorbed through skin.
Consumption of foods with fiber and compounds can promote gastrointestinal health and reduce obesity complications. Therefore, treatment with common bean leaves (BL) against obesity was evaluated in mice with a high-fat and high-fructose diet (HFFD) for 14 weeks. The bromatological and phytochemical characterization of BL were determined. Afterwards, the animals were supplemented with BL (10%) or a standard diet (SD) as a strategy to encourage a healthy diet for 12 additional weeks. Changes in body composition, lipid profile, and intestinal integrity were analyzed. The characterization of BL stood out for its content of 27.2% dietary fiber, total phenolics (475.04 mg/100 g), and saponins (2.2 mg/100 g). The visceral adipose tissue (VAT) decreased in the BL group by 52% compared to the HFFD group. Additionally, triglyceride levels were 23% lower in the BL consumption group compared to the HFFD group. The improvement in lipid profile was attributed to the 1.77-fold higher fecal lipid excretion in the BL consumption group compared to the HFFD group and the inhibition of pancreatic lipase by 29%. Furthermore, BL supplementation reduced the serum levels of IL-6 (4.4-fold) and FITC-dextran by 50% compared with those in the HFFD group. Metabolic endotoxemia was inhibited after BL supplementation (-33%) compared to the HFFD group. BL consumption as a treatment in obese mice reduces adipose tissue accumulation and improves the lipid profile. Furthermore, we report for the first time that BL consumption improves intestinal integrity.
PURPOSE: A composition containing Lilium Candidum extract and carriers is provided to suppress malanogenesis with low cytotoxicity. CONSTITUTION: A composition for skin lightening contains extract prepared from Lilium Candidum whole plant, flowers, stems, leaves, or combination thereof. The extract contains 0.1 wt% of polyunsaturated fatty acid with a structure of chemical formula I(R-COOH). The extract additionally contains polysaccharides, oligosaccharides, disaccharides, and combination thereof. The composition further contains skin lightening agent. A facial mask contains a mask substrate and the composition.
The invention belongs to the technical field of biological medicines, and particularly relates to a fibroblast vaccine, a preparation method and application thereof. The invention aims to provide a new choice for treating organ fibrosis. The technical scheme of the invention is that the inactivated fibroblast vaccine has a main active ingredient of fibroblast activated by basic fibroblast growth factor (bFGF). The invention also provides a preparation method of the fibroblast vaccine, which comprises the following steps: 1) Primary fibroblast acquisition; 2) bFGF stimulates fibroblasts; 3) And (5) inactivating by irradiation and freezing. All of the foregoing operations are accomplished under aseptic conditions. The fibroblast vaccine provided by the invention has the advantages of strong immunocompetence, high clinical safety and the like, and is an excellent cell vaccine for organ fibrosis.
A portable medical device includes a portable medical bag, a plurality of connectors and a processor. These connectors respectively connect the portable medical bag and every medical device contained inside the portable medical bag. The portable medical bag obtains the device management information of each the medical device through these connectors. The device management information includes the remaining power of medical device. The processor calculates the charge strategy information of the corresponding medical device according to the medical device information, address information and device management information. In addition, a management method for portable medical device is also provided.
A synthetic hemagglutinin (sHA) which represents the highest degree of conservation in the HA sequences of all Influenza B viruses (IVB) based on comprehensive bioinformatics analyses was cloned into an adenoviral vector. The recombinant adenovirus carrying the sHA gene was then delivered intransallyintranasally into DAB/2 mice. The animals were challenged with 5xLD50 influenza B viruses. We have found that the synthetic HA vaccines afford 100% protection against lethal challenge whereas 50% mice died in the control group. Furthermore, no virus was found in the lung of the vaccinated group while significant lung viruses were found in all mice of the controlled group. Consistent with the survival data and virus titre, severe pneumonia was found in all mice of the control group while no pathologic observation was made in animals receiving the vaccines.
The study has three phases: in the first phase (Phase I) a baseline pretreatment schistosomiasis morbidity assessment of children aged 1-5 years will take place. The Kato-Katz technique will be used to detect and enumerate S. mansoni eggs in faecal samples from each participating child. Communities with the highest S. mansoni prevalence and intensity will be chosen and included in the study. In the second phase (Phase II) the S. mansoni positive children will be divided randomly into two intervention groups, single and double dose praziquantel treatment arms. Abdominal ultrasound will be combined with clinical examination to accurately identify hepatosplenomegaly. The sizes of both the liver and spleen will be examined. Anthropometric measurements and Hb for each child will also be recorded. In the last phase (Phase III), the effect of praziquantel on S. mansoni morbidity will be evaluated in all the treated children aged 1-5 years.
1. A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula I   wherein R<1> and R<3> are independently hydrogen,   wherein Ar is optionally substituted phenyl; R<2> is selected from the group consisting of pyrrolidine, hexamethylenemino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof; alone or in combination with one or more melanoma-inhibiting agents. 2. The method of claim 1 wherein said compound is the hydrochloride salt thereof. 3. The method of claim 1 wherein said compound is   or its hydrochloride salt. 4. The method of claim 1 wherein said administration is in combination with one or more of cisplatin, dacarbazine or carmustine. 5. The method of claim 1 wherein said melanoma is metastatic.
Death rate in patients affected with respiratory tract involvement is high as oxygenation level falls to the critical low level. Once critical low level is achieved irreversible hypoxia sets in and multi organ failure takes place which may eventually lead to the death. Currently there is no solution available in medicine form. External oxygen can be administered but skilled person, facilities are required beside they are costly and may not be available in vicinity. Current invention provides composition for clearing respiratory tract involvement and improving oxygenation comprises a garlic essential oil, a curcumin, a tincture benzoin, a bhimseni camphor, a clove oil, a eucalyptus oil, a menthol and an ethyl alcohol. It may optionally comprise one or more from an alpha tocopherol, a black pepper oil, a sandalwood essential oil, a tulsi essential oil, a methylene blue dye, a cinnamon oil, a thymol, water and a solubilizing and emulsifying agent.
This Stage II trial builds on the Stage I trial that compared the single-gender WRG to mixed-gender GDC and demonstrated preliminary support for the WRG in treating women with substance use disorders (SUDs). It was hypothesized that women in the WRG would decrease their substance use more so than women in the GDC. The GDC was chosen as the comparison group to approximate group drug counseling that is consistent with treatment as usual within the community. The WRG is a manual-based group therapy for women heterogeneous with respect to their substance dependence, co-occurring psychiatric disorders, trauma history, and age and stage of life. The WRG is a 12-session structured relapse prevention group therapy that utilizes a cognitive-behavioral approach and includes gender-specific content and single-gender group composition. There are 14 specific session topics that can be flexibly implemented in any order for a 12-week sequence of groups. In the Stage I trial, women were randomized to WRG (n=16) or mixed-gender GDC (n =7). No significant differences in outcomes emerged between WRG and GDC during the 12 week group sequence. However, in the 6 months post-treatment, WRG participants showed a pattern of continued reductions in substance use while GDC participants did not. While the design of the Stage I trial was essential for treatment development and testing, the Stage I trial had a small sample size and used a semi-closed enrollment format. However, most treatment is delivered in an open enrollment format (i.e., rolling admission) in which patients enter at any time in the group sequence and exit the group after 12 weeks are completed. Because WRG is intended to be a manual-based treatment ready for dissemination into clinical practice if demonstrated to be effective, the Stage II trial was designed to be implemented in an open group format and to enroll a larger, more diverse sample at two clinical sites. The study was designed to investigate the effectiveness of the WRG relative to the GDC in (1) reducing days of use of any substance from baseline in a sample of women with heterogeneity with regard to their substance dependence, co-occurring psychiatric disorders, and other demographic characteristics, and (2) to demonstrate the feasibility of implementing the WRG in an open-enrollment group format.
Vehicle and method is disclosed for treating and/or preventing skin disorders such as acne vulgaris and which exfoliates healthy skin by a topical application. The vehicle is a formulation incorporating hypohalous acid in a suitable pharmaceutical compound. The topical application comprises administering and scrubbing a therapeutically effective amount of hypohalous acid in the vehicle. The hypohalous acid may be hypochlorous acid, hypobromous acid, or hypoiodious acid. The suitable pharmaceutical vehicles include water, solutions, cleansers, lotion, cream, paper facial masks, and gels. The scrubbing action on the skin is exerted by a mechanic tool, such as hand, cloth towel, sponge, brush, and spraying device. Methods of preparing and compounding the vehicle for topical application and of its use are also set forth.
Postoperative gastrointestinal dysfunction, including temporary nonmechanical suppression of gastrointestinal motility (known as postoperative ileus), occurs in about 10% surgeries of abdominal tumors. Since these complications can prolong hospitalization and affect eating, it is important to understand their risk factors and identify effective interventions to manage or prevent them. The present review comprehensively examined the relevant literature to describe risk factors for postoperative ileus and effective interventions. Risk factors include old age, open surgery, difficulty of surgery, surgery lasting longer than 3 hours, preoperative bowel treatment, infection, and blood transfusion. Factors that protect against postoperative ileus include early enteral nutrition, minimally invasive surgery, and multimodal pain treatment. Interventions that can shorten or prevent such ileus include minimally invasive surgery, early enteral nutrition as well as use of chewing gum, laxatives, and alvimopan. Most of these interventions have been integrated into current guidelines for enhanced recovery of gastrointestinal function after surgery. Future high-quality research is needed in order to clarify our understanding of efficacy and safety.
China is a country with a heavy burden of gastric cancer and esophageal cancer. In 2015, the incidence/mortality of gastric cancer and esophageal cancer in China were 680000/500000 and 220000/200000, respectively. Gastroscopy is the most important means to detect early cancer of gastrointestinal tract. However, due to various factors, the miss rate of clinical significant lesions by gastroscopy is innegligible. Our previous research results showed that the detection rate of early gastric cancer and early esophageal cancer in China was only about 15%. This study aims to include 2000 gastroscopic procedures and investigate the relationship between procedure time and lesion detection rate in tertiary endoscopic centers in China.

At the first stage, the researchers observe the actual procedure time of gastroscopies without affecting the natural behavior of endoscopists. Then, researchers collect the data (including focal lesion detection rate, procedure time, detection rate of early upper GI cancer, biopsy rate and adverse event rate) and analyze the minimal procedure time. At the second stage, a minimal time limit will be set for each procedure. Every stage last two months, and potential correlations between lesion detection rate and procedure time will be investigated through subsequent statistical analysis.
Key message Three major QTLs for resistance to downy mildew were located within an 0.78 Mb interval on chromosome 8 in foxtail millet. Downy mildew, a disease caused by Sclerospora graminicola, is a serious problem that jeopardizes the yield and quality of foxtail millet. Breeding resistant varieties represents one of the most economical and effective solutions, yet there is a lack of molecular markers related to the resistance. Here, a mapping population comprising of 158 F6:7 recombinant inbred lines (RILs) was constructed from the crossing of G1 and JG21. Based on the specific locus amplified fragment sequencing results, a high-density linkage map of foxtail millet with 1031 bin markers, spanning 1041.66 cM was constructed. Based on the high-density linkage map and the phenotype data in four environments, a total of nine quantitative trait loci (QTL) associated with resistance to downy mildew were identified. Further BSR-seq confirmed the genomic regions containing the potential candidate genes related to downy mildew resistance. Interestingly, a 0.78-Mb interval between C8M257 and C8M268 on chromosome 8 was highlighted because of its presence in three major QTL, qDM8_1, qDM8_2, and qDM8_4, which contains 10 NBS-LRR genes. Haplotype analysis in RILs and natural population suggest that 9 SNP loci on Seita8G.199800, Seita8G.195900, Seita8G.198300, and Seita.8G199300 genes were significantly correlated with disease resistance. Furthermore, we found that those genes were taxon-specific by collinearity analysis of pearl millet and foxtail millet genomes. The identification of these new resistance QTL and the prediction of resistance genes against downy mildew will be useful in breeding for resistant varieties and the study of genetic mechanisms of downy mildew disease resistance in foxtail millet.
<P>PROBLEM TO BE SOLVED: To provide an implant for at least partially creating, recreating or stabilizing vertebra bodies or tubular bones.  <P>SOLUTION: In the implant, a ceramic hollow body is coated with an active ingredient complex or is filled with the above active ingredient complex. The active ingredient complex has the following components which differ from one another and are specifically adapted for creating bones: at least one structural component based on extracellular material which is specifically adapted to the cells of the bone which is to be created, at least one recruiting component, at least one adhesion component and at least one growth and/or maturation component. The ceramic hollow body preferably comprises calcium phosphate or aluminum oxide ceramic. The active ingredient can be applied to support materials which is selected from polymers and collagen.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Those qualified for enrollment will be randomized into a double-blind crossover study to consume 2 morning servings of a 0.6 cup (150g) of plain yogurt with : A) cane sugar added in an isocaloric level as the honey or, B) 1 tbsp of phenolic-rich honey for 4 weeks. A one-month washout between periods will be used. The participants will be instructed to consume one yogurt in replacement of or as part of breakfast, and as a late morning snack. They will also be instructed to not add any additional items to the yogurt. Therefore, each study participant will consume 2 tbsp. of honey a day for four weeks, which is a realistic amount typically consumed by honey users.
Treatment support systems and methods can select interactive opportunities for presentation to a patient. A system can generate first lists by independently selecting opportunities from an opportunity pool using first models based on competency levels of a patient and associations between the opportunities and competencies of the patient. The system can generate a second list by selecting opportunities from the first lists using a second model based on the competency levels and target competency levels for the patient. The system can provide the second list to a client device of the patient and receive from the client device a selection of an opportunity in the second list. The system can provide the selected opportunity to the client device and receive performance data from the client device. The performance data can concern performance of the selected opportunity. The system can update the competency levels based on the received performance data.
Biallelic mutations in the coenzyme Q7 (COQ7) encoding gene were recently identified as a genetic cause of distal hereditary motor neuropathy. Here, we explored the clinical, electrophysiological, pathological, and genetic characteristics of a Chinese patient with spastic paraplegia associated with recessive variants in COQ7. This patient carried a novel c.322C>A (p.Pro108Thr) homozygous variant. Sural biopsy revealed mild mixed axonal and demyelinating degeneration. Immunoblotting showed a significant decrease in the COQ7 protein level in the patient's fibroblasts. This study confirmed that COQ7 variant as a genetic cause of HSP, and further extended spastic paraplegia to the phenotypic spectrum of COQ7-related disorders.
Disclosed are substrates suited for dispensing air treatment chemicals upon being heated. Granular particles, preferably sand with a phenolic binder, are adhered together to form a substrate body having a network of pores. A volatile air treatment chemical is disposed in the pores. The particle size and pores are such that the smaller particles of the substrate are grouped at one end, preferably an end adjacent to a projecting nose. This structure tends to wick the volatile air treatment chemical towards the nose, and heating that area can lead to efficient, and rechargeable, dispensing. Methods for using such substrates, and methods for forming such substrates, are disclosed.
Participants will receive, in a random order, a placebo prior to exercise in normoxia, a placebo prior to exercise in hypoxia, 1000 mg of Aes-103 prior to exercise in hypoxia, and 3000 mg of Aes-103 prior to exercise in hypoxia. Each intervention is separated by a 7 day washout period.
PURPOSE: A gonad growth inhibiting composition is provided to effectively control the growth of gonad of fish by safely applying a natural extract to the fish. CONSTITUTION: A gonad growth inhibiting composition comprises an active substance of an Albizia julibrissin extract. The Albizia julibrissin extract is obtained by methanol extraction. 0.01-10 weight% of Albizia julibrissin extract is contained for the total feed composition. The composition delays the growth of reproductive cells of fish. The reproductive cells of the fish forms egg yolk. The composition maintains the concentration of steroid hormones of the fish in blood low compared to the fish without the composition. The composition extends the survival time of the fish. The composition is a fish feed composition. [Reference numerals] (AA) Concentration of an added extract(mg per 1g of feed)