anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
NEW MATERIAL:A sangenone having physical and chemical properties as follows (sangenone D): description: yellow powder, molecular weight: 708 (according to the field desorption mass spectrography), melting point: 175-185 deg.C (decomposed), [alpha]D<25>=-145 deg. (c=0.173 in methanol); positive to ferric chloride reaction and to hydrochloric acid-magnesium reaction, hard soluble in water, hexane, chloroform, soluble in ethyl ether or ethyl acetate, easy soluble in methanol, ethanol, DMF, acetone; acidic substance. USE:Hypotensor with low toxicity. PREPARATION:For example, barks of mulberry tree roots are finely cut, defatted with a low-polarity organic solvent, then extracted with a lower alcohol. The extract is filtered, the filtrate is dried under reduced pressure to obtain an extract. The extract is subjected to column chromatography to separate impurities and collect fractions containing sangenone D. Then, sangenone is isolated and purified.
PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin which possesses excellent melanin-forming effect, tyrosinase inhibitory activity and antioxidant effect by formulating a specific plant extract thereto. SOLUTION: This preparation for external use for skin contains an extract from the family Celastraceae the genus Maytenus plants, particularly espinkeira santa (Maytenus illicifolia), as an active ingredient. This preparation for external use for skin is preferably utilized as a skin whitening agent or an antioxidant. The above extract is formulated with the preparation for external use for skin in an amount of 0.005-20.0 wt.% as the dry product. This preparation for external use for skin shows excellent effect in color-lightening and whitening pigmentation after getting sunburn, stains, freckles and liver spots. In addition, due to the antioxidant effect, it is excellent in safety. By formulating it with a cosmetic material, the cosmetic is effective for preventing oxidation of lipid components in skin, oxidative injury to skin and skin aging and can protect skins.
Male or female inpatients, age ≥ 18 and ≤ 80 years, who are in normal sinus rhythm and do not have a pacemaker or other indwelling intracardiac device and require PICC insertion for their routine care will be studied. Intervention: ECG-guided Power PICC placement.
The invention discloses externally-applied medicinal liquid for treating earache and a preparation method thereof. Flying centipedes are soaked in rice wine according to a weight ratio of 1:3. The flying centipedes are obtained from earth beneath grass on mountains. The rice wine is 40 to 50 degrees. The preparation method comprises: washing away earth on elliptic flying centipedes from earth beneath grass on mountains, completely drying in the air, placing into a glass bottle, injecting 40 to 50-degree rice wine, soaking according to a weight ratio of the flying centipedes to the rice wine of 1:3, and sealing the glass bottle for soaking for 10 to 15 days. When the externally-applied medicinal liquid prepared by the flying centipedes is used for treating earache, the treatment effect is obvious.
The α-glucosidase inhibitor voglibose was developed by Takeda Pharmaceutical Co. Ltd and is one of the most commonly used oral antidiabetic agents in Japan. Voglibose is used as first-line treatment for improvement of postprandial hyperglycemia in diabetic patients with inadequate response to diet and exercise therapy and as add-on treatment to other oral antidiabetic drugs and insulin. In 2009, voglibose was approved in Japan for the management of prediabetes (IGT).

This study was a single-group, multi-center, open-label study. The study period consisted of a screening period of 1 week or less, a treatment period of 96 weeks or more, and a follow-up period of 48 weeks. However, if a patient was assessed as having type 2 diabetes mellitus or normoglycemia, the treatment period was to be ended, and only those assessed as normoglycemic were to proceed to follow-up. Follow-up was also to be terminated if patients were assessed as having IGT or type 2 diabetes mellitus during follow-up.
PROBLEM TO BE SOLVED: To obtain the subject stable aqueous solution preparation by admixing β-lactoglobulin (β-LG) and human calcuitonin (h-CT). SOLUTION: This preparation is obtained by formulating β-LG one of protein components in milk to an aqueous solution of h-CT. In the production of this preparation, β-LG is dissolved in a suitable aqueous solvent as distilled water or tap water, the pH of the solution is adjusted to <=4, then h-CT is dissolved therein. The concentration of h-CT is suitably 0.5-10 mg/ml, β-LG is 1-40 mg/ml, suitably. This preparation may contain a mucous absorption promoter, stimulation alleviator, isotonizing agent, thickener, preservative and other additives. Since β-LG is formulated, the preparation is stable since its coagulation of h-CT is delayed.
3,4-Aminopyridine or Amifampridine belongs to the aminopyridine class of drugs which is used to treat multiple sclerosis and Lambert-Eaton Myasthenic Syndrome (LEMS). Aminopyridine pharmaceuticals inhibit presynaptic potassium channels. This increases available acetylcholine in the nerve cleft which leads to improved strength in this patient population. While overdoses have been reported of 4-Aminopyridine, no case reports of acute 3.4-Aminopyridine overdose are currently available. A 67 year old man presented to the emergency department 30 min after ingesting 100 mg of amifampridine in a suicide attempt. Within an hour of ingestion he experienced tachycardia, tachypnea, hypertension and tremor. The patient then started to experience seizures and had a cardiac arrest 3 h after the ingestion. The patient achieved return of spontaneous circulation but proceeded to have refractory seizures. Despite significant and escalating doses of anti-epileptic medications, the patient continued to have seizures until 18 h after ingestion. His anti-epileptic medications were weaned over the following days and he had no more seizures. This is a report of a novel overdose of 3,4-Aminopyridine, a medication that belongs to the aminopyridine class of pharmaceuticals that have been well used for many years. Aminopyridine overdoses are commonly thought to carry low morbidity and mortality; however, our patient had both a cardiac arrest and refractory status epilepticus. Ultimately, this case suggests that patients who overdose on 3,4-Aminopyridine could become critically ill and their presentation may be far more severe than that of other medications of the same class.
A medical information retrieval system includes a natural language processing system that processes voice user queries to identify keywords and phrases. These keywords and phrases are provided to an inference engine that provides a set of knowledge-based inferences from a medical knowledge source based on the keywords and phrases. These knowledge-based inferences are then provided to an information retrieval engine that retrieves a corresponding plurality of medical articles based on the knowledge-based inferences and ranks each medical article with respect to the knowledge-based inferences. The summarization engine receives the ranked articles and creates a model based on the topic keywords and candidate sentences found in the highly ranked articles. The paraphrasing engine processes the candidate sentences to provide a summary response according to a knowledge-based paraphrasing model. The audio output device presents the summary report as a response to the user's original voice query.
Non-twins 6-12 mo Flu/MMRV Naïve (annual return): In 2014-2015, participants 6-12 mo who are flu and MMRV naïve will be given Fluzone® inactivated influenza vaccine quadrivalent (IIV4) as an IM injection. In Year 1, participants will return for a second flu immunization at least 28 days later and for blood samples on Days 0 and 60 post-second immunization and on Day 60 post MMRV (to be given by primary care physician). In Years 2-5, participants will return annually for Fluzone® IIV4 flu immunization and for blood samples on Days 0 and 60 post-immunization.
In cheese making, whey is the liquid that is separated from the clot formed as a result of coagulation of milk with rennet or acid, does not coagulate and contains milk dry matter. Serum proteins in whey increase the nutritional value of whey proteins and help the absorption of minerals. In addition to their nutritional value, whey proteins have important health effects in terms of other metabolic functions such as strengthening immunity, stimulating gastrointestinal hormone secretion, antiviral activity, and satiety response. Therefore, the aim of this study was to add whey powder, which is lost as waste in cheese production and has many health benefits, to bread, which is consumed very much daily in Turkey, to enrich bread in terms of nutrients and to examine the effect of whey powder added bread on postprandial blood glucose. The study is planned to be conducted in 20 healthy individuals aged 19-35 years with normal body mass index (18.5-25.0 kg/m2) between August 2024 and March 2025. In the study, all volunteer participants will be randomly assigned to a breakfast meal consisting of all bread types (bread made from white flour, bread made from white flour with whey powder added, bread made from whole wheat flour and bread made from whole wheat flour with whey powder added) for four consecutive days. During these days, participants will have their fasting blood glucose measured immediately before the meal containing the test bread and will then be asked to consume the entire test bread with their breakfast meal within 15 minutes. After breakfast, postprandial blood glucose will be measured at 15, 30, 45, 60, 90, 120 minutes. Food consumption records will be taken by the researchers and participants will be instructed not to eat or drink anything 8 hours before breakfast and not to perform any physical activity other than their daily activities during that day. Anthropometric measurements will be taken by the researchers using appropriate methods and food consumption records will be questioned in detail on a daily basis. According to the food consumption record, the types and amounts of foods consumed daily will be determined and energy, macro and micronutrient values will be analyzed using the Turkey Specific Nutrition Information System (BeBIS) computer program. There is no study in the literature investigating the effect of whey powder added to bread on blood glucose. In addition, enriching bread, which is very important in the nutrition of the Turkish nation, with whey powder, which is considered as "waste", will contribute to both sustainability and economy.
Meralgia paresthetica is a mononeuropathy of the lateral femoral cutaneous nerve (i.e. lateral cutaneous nerve of the thigh). It is known as the lateral cutaneous nerve of the thigh neuralgia. It is due to a lot of etiologies. It is characterized by neuropathic pain, tingling, paresthesia and numbness in the anterolateral aspect of the thigh. The symptoms may be provoked or worsened by prolonged standing and walking. Sitting may alleviate the pain because there is reduction of the tension over the nerve, The treatment of meralgia paresthetica is directed towards the improvement of the symptoms which is mainly pain with subsequent improvement of function and quality of life, as well as, treatment of the etiology. The treatment includes conservative and surgical treatment. Conservative treatment consists of non-pharmacologic treatment and pharmacologic treatment. Surgical treatment takes place in case of failure of the conservative treatment. Surgical options consist of neurolysis and neurectomy.

Neural prolotherapy was reported to improve and relieve of neuropathic pain including that of meralgia paresthetica. Neural prolotherapy is the subcutaneous perineural injection of isotonic dextrose (5%) solution especially at the points of fascial penetration of the sensory nerve. It is the site where the sensory nerve reaches the subcutaneous plane. There are scanty studies assessed this issue.

The aim of the current study was to assess the efficacy of neural prolotherapy (subcutaneous perineural injection of dextrose 5% solution) on reliving pain and improvement of function and quality of life in patients with meralgia paresthetica.
A method of administering dienogest to a women in high dosages for reducing the body of the breast is described. The dosage should be at least ten times the effective dosage for inhibiting ovulation in the women. A pharmaceutical composition for use in the method is also described. Furthermore, retrogression of mastopathic changes in the body of the breast can be brought about. Dienogest is also outstandingly suitable for the prophylaxis of mastopathies. In high dosages, dienogest prevents the formation of mastopathic changes in the body of the breast.
Imatinib (IM), a breakthrough in chronic myeloid leukemia (CML) treatment, is accompanied by discontinuation challenges owing to drug intolerance. Although BCR-ABL1 mutation is a key cause of CML resistance, understanding mechanisms independent of BCR-ABL1 is also important. This study investigated the sphingosine-1-phosphate (S1P) signaling-associated genes (SphK1 and S1PRs) and their role in BCR-ABL1-independent resistant CML, an area currently lacking investigation. Through comprehensive transcriptomic analysis of IM-sensitive and IM-resistant CML groups, we identified the differentially expressed genes and found a notable upregulation of SphK1, S1PR2, and S1PR5 in IM-resistant CML. Functional annotation revealed their roles in critical cellular processes such as proliferation and GPCR activity. Their network analysis uncovered significant clusters, emphasizing the interconnectedness of the S1P signaling genes. Further, we identified interactors such as BIRC3, TRAF6, and SRC genes, with potential implications for IM resistance. Additionally, receiver operator characteristic curve analysis suggested these genes' potential as biomarkers for predicting IM resistance. Network pharmacology analysis identified six herbal compounds-ampelopsin, ellagic acid, colchicine, epigallocatechin-3-gallate, cucurbitacin B, and evodin-as potential drug candidates targeting the S1P signaling genes. In summary, this study contributes to efforts to better understand the molecular mechanisms underlying BCR-ABL1-independent CML resistance. Moreover, the S1P signaling genes are promising therapeutic targets and plausible new innovation avenues to combat IM resistance in cancer clinical care in the future.
PCT No. PCT/FR94/00564 Sec. 371 Date Feb. 2, 1995 Sec. 102(e) Date Feb. 2, 1995 PCT Filed May 11, 1994 PCT Pub. No. WO94/26283 PCT Pub. Date Nov. 24, 1994A method of treating a living organism having a disease associated with demineralization or mineralization defects of an existing bone by applying in a spongy portion of the bone or in a medullary canal of the bone at least one biocompatible and bioabsorbable calcium salt in the form of particles having dimensions less than 8 mm. The biocompatible and bioabsorbable calcium salt is an active ingredient for reinitiating bone remineralization and reconstruction of resorbed bone spans and increases bone density and bone mass.
PURPOSE:To provide a composition containing carotenoid and lecithin as main ingredients and having a lipidperoxide-lowering action. CONSTITUTION:The objective composition contains 0.1-10 pts. of carotenoid and 99.9-90 pts. of lecithin preferably in a compounding ratio of 1:(99-95). The cartenoid is a strongly lipophilic substance and includes beta-carotene and astaxanthine, and the lecithin as a phospholipid includes soybean lecithin and york lecithin. The composition containing the homogeneous mixture of the carotenoid with the lecithin exhibits an action to reduce the increase in the amount of lipidperoxide in a living body by its oral administration, etc., the increase being recognized in the patients of hypertension, diabetes, cerebral hemorrhage, cancer, etc.
The container includes a housing with a liquid containment section, defined in part by a common wall, that holds the fluid. A movable member defines, in a first position and in conjunction with the common wall, a sealed interior chamber within which is disposed the mixable or solid composition. In a second position, the movable member is raised above the common wall thereby mixing the mixable composition and the fluid in a mixing section. The mixing section is a combination of the liquid containment section and the interior chamber. The container also includes a lid which is removably attachable to the housing and is operatively associated with the movable member such that when the lid is removed, the movable member is enabled to move from the first position to the second position. The container also includes a port for dispensing the resultant fluid derived from mixing the mixable composition and the fluid. The port is defined by the hollow body, movable member which has an open top and an open bottom. The method for storing, mixing and dispensing includes the steps of providing a movable member that isolates the mixable composition, containing the fluid about a portion of the movable member which isolates that composition, and substantially concurrently moving the member, exposing the mixable composition to the fluid and exposing the resultant fluid to the ambient environment.
The long term objective of this project is to develop an understanding of lifestyle factors that influence the cognitive and brain health of children while also reducing the sedentary nature of today's youth. Previous research has found that physical activity interventions can enhance both a variety of aspects of cognition and brain structure and function of children, older adults, and individuals with neurodegenerative disorders such as Parkinson's disease and multiple sclerosis. More specifically, in previous research with children the researchers have found that higher fit children possess larger hippocampi which in turn are related to better relational memory than their lower fit counterparts. The researchers have also observed that higher fit children exhibit more efficient executive control as indicated by performance measures and event-related brain potentials. While intriguing, these cross-sectional data do not enable us to establish causality between physical activity and cognition. In the current study the researchers substantially extend this previous research by examining the influence of a 9 month randomized controlled afterschool physical activity program on cognition and brain health. Cognition will be assessed with a battery of tasks and standardized achievement tests both before and after the 9 month intervention in the activity group and a wait list control (who will receive the intervention the following year). Children will also participate in magnetic resonance imaging (MRI) sessions both before and after the intervention (and at comparable times for the wait list control). In these sessions the researchers will measure both structural aspects of the brain including regional volumes of gray matter and the integrity of the white matter tracts (through diffusion tensor imaging) and functional aspects of brain function using fMRI activity recorded as the children perform a series of executive control and memory tasks. The researchers anticipate, based on our cross-sectional studies with children and our previous longitudinal studies with older adults, that the children in the physical activity program will show both larger regional brain volumes, particularly in brain regions that subserve executive control and relational memory, and more efficient brain function, as indexed by task-related and resting state fMRI. Furthermore, the researchers anticipate that these changes will be accompanied by improvements in memory and executive control processes. Given recent trends identifying decreased levels of physical activity and health status in preadolescents, the understanding of the potential benefits of physical activity on cognition is of great interest. It is imperative that factors positively influencing cognitive function of children be examined to maximize health and effective functioning of individuals as they progress through the lifespan.
A server system includes motherboards, a control circuit and a system fan. Each motherboard can generate a PWM signal. The control circuit includes charge/discharge routes for receiving PWM signals, a comparator and a selector. These PWM signals can charge/discharge these routes to generate end voltages. A comparator compares these end voltages to generate a result signal. A selector selects one of the PWM signals to control a system fan based on the result signal.
A 48-year-old man with no history of diagnosis with any abnormality was admitted to our hospital 43 min after onset of stroke. He had a right conjugate deviation and severe left hemiparesis, and his initial National Institutes of Health Stroke Scale (NIHSS) score was 13. Computed tomography (CT) of the head revealed no early ischemic changes, while CT angiography showed occlusion of the M1 proximal segment of the right middle cerebral artery. Intravenous thrombolysis was administered within 27 min of admission, and mechanical thrombectomy was performed. Effective reperfusion was achieved 55 min after puncture. Carotid web (CaW) at the root of the right internal carotid artery was suspected to be the source of the embolus. Carotid ultrasonography (CUS) on the following day revealed an oval-shaped structure of equal intensity rising from the far wall. The structure enlarged over time, despite the administration of an antiplatelet agent. In addition to thrombi, intramural hematoma and neoplastic lesions were considered in the differential diagnosis. Carotid endarterectomy was performed on day 6. Pathologically, a mixed thrombus was identified adhering to the CaW; however, no neoplastic changes were observed. There were no postoperative complications, and the patient was discharged without neurological deficits on day 14. The CaW has anatomical factors morphologically associated with a high risk of thrombus formation. Pathologically, the involvement of hydrodynamic factors was considered more significant than the influence of the CaW surface morphology. CUS is a useful tool for assessing thrombus morphology.
Pediatric skeletal muscle channelopathies include a spectrum of conditions including nondystrophic myotonias and periodic paralyses. They are rare inherited conditions that can cause significant morbidity. They are characterized by episodic stiffness and weakness. While there is significant phenotypic variability, there are distinct diagnostic features. The nondystrophic myotonias encompass myotonia congenita, paramyotonia congenita, and sodium channel myotonia caused by mutations in chloride and sodium channels. The clinical manifestations vary across age groups and a small subset with sodium channel mutations may have severe presentation with fetal akinesia, laryngospasm, or congenital myopathy. The periodic paralyses include hypokalemic periodic paralysis, hyperkalemic periodic paralysis, and Andersen-Tawil syndrome. The phenotypic differences between the groups can be helpful in diagnosis. It is important to review the cardiac phenotype in Andersen-Tawil syndrome due to a risk of life-threatening cardiac arrhythmias. Early and accurate diagnosis utilizing clinical features aided by investigations is important across all the pediatric channelopathies, as effective symptomatic treatment is available and can substantially improve quality of life.