anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: organic chemistry, vitamins. SUBSTANCE: invention relates to derivatives of vitamin D of the general formula (I)   where X - H, OH; R 1  and R 2  are similar or different C 1 -C 6 -alkyl, possibly, substituted with fluorine atoms; Q - a single bond or group (CH 2 ) n  where n = 0, 1, 2 or 3 being OH-groups can be protected and their splitting off occurs in vivo, or their diastereomers. Compounds show antiinflammatory and immunomodulating action and strong inducing effect with respect to differentiation and inhibition of some cells proliferation. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 5 cl, 4 tbl
The current invention provides methods to identify gamma9delta2T-cell receptors (gamma9delta2TCR) that mediate anti-tumour responses. Surprisingly, it was now found that the CDR3 regions of the gamma9-T-cell receptor chain and the delta2-T-Cell receptor chain (delta2TCR chain) are of importance. Based on these findings, combinatorial-gammadeltaTCR-chain-exchange (CTE) is proposed as an efficient method for identifying gamma9delta2TCRs that mediate anti-tumourresponses.Using the method of the invention, specific sequences of the respective gamma9TCR and delta2TCR chains were identified that mediate anti-tumour responses. Hence, the invention further provides for specific gamma9delta2TCRs, or fragments thereof, that may be used e.g. in diagnostics or treatment of cancer. The invention further provides for nucleic acid sequences, genetic constructs and retroviral vectors that can be used to express the gamma9delta2TCRs according to the invention.
Investigators will use a quasi-experimental interrupted time series (ITS) design that allows for a continuous sequence of observations on a population, taken repeatedly over time (Bernal et al., 2017). ITS design provides an estimate of the causal effect of a discrete intervention; the design begins with measurements on a dependent variable and the intervention breaks ("interrupts") this time series into preintervention and post-intervention time points. Data will be collected from two group an "Immediate Start Group" and a "Delayed Start Group" (who will serve as a control group for the ITS design).
This study proposes an extendable modelling framework for Digital Twin-Oriented Complex Networked Systems (DT-CNSs) with a goal of generating networks that faithfully represent real-world social networked systems. Modelling process focuses on (i) features of nodes and (ii) interaction rules for creating connections that are built based on individual node's preferences. We conduct experiments on simulation-based DT-CNSs that incorporate various features and rules about network growth and different transmissibilities related to an epidemic spread on these networks. We present a case study on disaster resilience of social networks given an epidemic outbreak by investigating the infection occurrence within specific time and social distance. The experimental results show how different levels of the structural and dynamics complexities, concerned with feature diversity and flexibility of interaction rules respectively, influence network growth and epidemic spread. The analysis revealed that, to achieve maximum disaster resilience, mitigation policies should be targeted at nodes with preferred features as they have higher infection risks and should be the focus of the epidemic control.
Osteoid osteoma is a benign bone-forming tumour, seen more frequently in males than females, during the first three decades of their life. It accounts for 3% of all bone neoplasms and 10-12% of benign bone lesions. The spine is involved in approximately 10-20% of cases. A teenage boy presented with complaints of low back pain and spinal deformity for 2 years. He was previously treated for tuberculosis of that same segment empirically. A whole-body PET scan was taken, which revealed the presence of osteoid osteoma. The patient underwent complete resection of the osteoid osteoma from the L3-L4 facet joint and transforaminal lumbar interbody fusion. The patient had good pain relief following the procedure, and he was able to carry out all his daily activities on a 1-year follow-up with no recurrence.
PURPOSE:To provide a blood preservative containing an amino acid transfusion, exhibiting antihemolytic activity similar to sucrose against the drop of osmotic pressure of erythrocyte, and usable for blood transfusion directly without removing the amino acid. CONSTITUTION:An amino acid transfusion, preferaly containing essential amino acids (e.g. tryptophan, phenylalanine, lysine, threonine, etc.) is used as a component of the objective blood preservative. The content of amino acid is preferably 1-15wt%. The wall of erythrocyte can be protected and reinforced and the hemolysis of the preserved blood can be prevented by the addition of the amino acid transfusion. When the erythrocyte concentration in the blood transfusion operation is lower than that of the blood, the blood containing said transfusion can be used as it is. In the case of using a concentrated erythrocyte preparation, it is diluted with an isotonic physiological saline water or with the amino acid transfusion of the present invention.
Hypothalamic obesity is when individuals suffer from acute weight gain after brain tumor treatment, involving secondary damage to the ventromedial nucleus of the hypothalamus, which may lead to obesity. The weight gain is uncontrolled and not receptive to diet and exercise interventions. The rate of long-term obesity in children diagnosed with craniopharyngioma can be as high as 50%. Exenatide, a drug indicated for diabetes, is an incretin mimicking agent that mimics the enhancement of glucose-dependent insulin secretion and several other antihyperglycemic actions of incretins has resulted in weight loss when given to diabetics. Exenatide shows potential to benefit patients suffering from hypothalamic obesity by slowing gastric emptying and therefore reducing food intake. Also increasing the glucagon-like peptide 1 (GLP-1) circulation, decreased due to obesity, at the already compromised GLP-1 receptor site of the hypothalamus could potentially help with regulation of appetite.
Two I-shaped kinesio tapes in 40 cm length will be applied bilaterally, beginning from 5 cm below the spina iliaca posterior superiors (SIPSs) to the level of the 12th costae, in maximum trunk flexion position, on the paravertebral muscles, by inhibition technique of muscle correction techniques. The tapes will be placed with no tension at 5 cm of both ends, and with 15-25% tension in between. In addition, an extra I-shaped tape will be placed perpendicullar to these tapes with the ligament correction technique, while the pregnant women are in the vertical upright position, at the level of the sacroiliac joints, starting with a tensile strength of 75-100% from the middle, and then with no tension at two ends.
Idiopathic pulmonary fibrosis (IPF) is a poor prognosis disease that affects approximately 5 million people worldwide, and the detailed mechanisms underlying the pathogenesis of IPF remain unclear. Bleomycin-induced pulmonary fibrosis has been widely used as a representative animal model of IPF that induces fibrosis in lung tissue. The lungs of rodent consist of five lobes and each bronchus enters each lobe of the lung at a different bifurcation angle, path length, and diameter. The method of administration of bleomycin is considered as important thing to establish appropriate animal models. We conducted a time-dependent histopathological study to examine how pulmonary fibrosis develops in each lung lobe when bleomycin was intratracheally sprayed in ICR mice. And we then explored the suitable points for evaluation of anti-fibrotic agents in this model. As a result, we found that homogeneous fibrosis was induced in the 5 lobes of the lungs following initial inflammation. The expression of transforming growth factor (TGF)-β1 and phospho-Smad2 (pSmad2) was observed from Day 1, and their positivity increased until Day 21. In conclusion, we have observed a detailed time course of histological changes in bleomycin-induced pulmonary fibrosis in ICR mice using the aerosolization technique. We found that our protocol can induce a highly homogeneous lesion in the lung and that the most suitable time point to assess anti-fibrotic agents is 14 days after treatment in this model.
People living with HIV comprise a substantial number of the patients admitted to intensive care. This number varies according to geography, but all areas of the world are affected. In lower-income and middle-income countries, the majority of intensive care unit (ICU) admissions relate to infections, whereas in high-income countries, they often involve HIV-associated non-communicable diseases diagnoses. Management of infections potentially resulting in admission to the ICU in people living with HIV include sepsis, respiratory infections, COVID-19, cytomegalovirus infection, and CNS infections, both opportunistic and non-opportunistic. It is crucial to know which antiretroviral therapy (ART) is appropriate, when is the correct time to administer it, and to be aware of any safety concerns and potential drug interactions with ART. Although ART is necessary for controlling HIV infections, it can also cause difficulties relevant to the ICU such as immune reconstitution inflammatory syndrome, and issues associated with ART administration in patients with gastrointestinal dysfunction on mechanical ventilation. Managing infection in people with HIV in the ICU is complex, requiring collaboration from a multidisciplinary team knowledgeable in both the management of the specific infection and the use of ART. This team should include intensivists, infectious disease specialists, pharmacists, and microbiologists to ensure optimal outcomes for patients.
PURPOSE: A method of coating the surface of inorganic powder particles with a silicon-carbon composite, and inorganic powder particles surface-coated with the silicon-carbon composite manufactured thereby are provided to form a thin and uniform coating film compared to a liquid coating method, to form a superhydrophobic silicon-carbon composite coating film having a high stability to ultraviolet rays, and to enable the silicon-carbon composite coating to be used as anti-oxidation layer of a sample. CONSTITUTION: A method of coating the surface of inorganic powder particles with a silicon-carbon composite comprises a step of mixing inorganic powder particles and solidified silicone organic polymers, and a step of heating the mixture. The inorganic powder particles are at least one selected from the group consisting of titanium dioxide, zinc oxide, zirconium oxide, copper, nickel, carbon fibers, and activated charcoal. The solidified silicone organic polymers are obtained by adding a curing agent in the silicone organic polymers. The silicone organic polymers are polydimethylsiloxane, polyvinylsiloxane, polyphenylmethylsiloxane, or their combination. The curing agent is organic peroxide. The heating is performed at 150-300 deg. C.
The body's immune response to injury otr infection is very complex. Immune cell activity, the release of specific mediators (such as proteins), genetics (Deoxyribonucleic acid or DNA) and/or the body's "instructions" for making proteins (Ribonucleic Acid or RNA) may effect the body's clinical response to a stress such as an infection.Hydrocortisone is a substance produced by the body (in the adrenal gland)in response to stress such as infection or injury. Endotoxin is a man- made substance, which causes the body to "mimic" sickness (fever, chills, and achiness) for a few hours. This study is designed to give hydrocortisone before and/or after endotoxin to determine if this medication can prevent or relieve any of the symptoms caused by endotoxin.In addition, this study may determine whether any of the above(proteins,DNA,RNA,etc.) correlate with or affect the body's response to hydrocortisone and/or endotoxin. This will enable the investigator to better understand whether treatment with this substance can alter the body's immune response.
<P>PROBLEM TO BE SOLVED: To make a medical examination efficient by rationarizing input in an electronic chart.  <P>SOLUTION: A medical chart sheet having a mark sheet filling column at least including alternatives regarding a medical examination result of a doctor is provided at a part of the medical chart sheet. Furthermore, a system having a means for optically reading the medical chart sheet and a storage means for storing read information by associating it with patient information is included. Furthermore, a system including a means for rearranging the alternatives in an order of use frequency, a means for preferentially outputting the rearranged alternatives from the one with high use frequency and the one used last are included. In addition, a means for optically scanning a manually written medical chart and for storing the chart as an image by associating it with the data is included.  <P>COPYRIGHT: (C)2004,JPO
This study has two parts: 1a and Ib. Ia is a single agent study, and Ib is a combination study, testing the safety of JS014 with 200 mg of pembrolizumab. After being informed about the study and the potential risks, all subjects giving written informed consent will receive at most 4-week screening procedures to ensure the eligibility of the study entry. Once eligible, the subjects will receive JS014 infusion at the designated dose levels once every week until disease progression. In Ia study, only JS014 is given. In Ib study, JS014 will be given once a week with pembrolizumab at 200 mg once every three weeks until disease progression. The subjects will receive safety evaluation, pharmacokinetic and pharmacodynamic studies, as well as efficacy evaluation at regular interval.

The maximum number in each part of the study is 30 subjects. The Ia study will be conducted in Taiwan, and Ib study will be conducted in both Taiwan and the United States.
The invention relates to a traditional Chinese medicine capsule for treating ischemic necrosis of caput femoris. The capsule comprises the following traditional Chinese medicine raw materials in weight portion: 100 portions of prepared rhizome of rehmannia, 200 portions of rhizoma drynariae, 100 portions of cassia twig, 200 portions of root of herbaceous peony, 100 portions of liquorice, 150 portions of angelica, 200 portions of reticulate millettia, 200 portions of mistletoe, 150 portions of radix achyranthis bidentatae, 50 portions of pangolin, 100 portions of centipede, 50 portions of pawpaw, 100 portions of lycopodium calvatum, 100 portions of ants, 50 portions of whole worm, 100 portions of frankincense, 100 portions of myrrh, 200 portions of dragon blood, 60 portions of nux vomica, 60 portions of asarum, and 100 portions of honey-suckle stem. Various compositions can be directly purchased. The preparation method for the traditional Chinese medicine capsule comprises the following steps: the compositions are rolled into powder together and pass through a sieve with meshes between 80 and 100; medicinal powder is loaded into hollow capsules; and the capsules are loaded into a bottle and are sealed. The treatment of the ischemic necrosis of caput femoris by the traditional Chinese medicine capsule has quick effect and high cure rate, does not stimulate stomach, and has no toxic side effect. The capsule application of 202 clinical patients proves that the effective rate reaches 100 percent, and the cure rate reaches 85 percent.
The application discloses an exosome-loaded hydrogel and a preparation method and application thereof. The hydrogel loaded with the exosomes comprises a gel substrate and the exosomes loaded on the gel substrate, wherein the mass ratio of the exosomes to the gel substrate is 0.5-5:100000. The preparation method of the hydrogel is simple, quick and high in repeatability, and is suitable for industrial production. The prepared exosome-loaded composite hydrogel has the advantages of local high concentration and low toxicity of the whole body, and has the characteristics of skin permeability, long residence time and the like. In addition, the exosome-loaded composite hydrogel also has injectable, biodegradable and slow-release properties. In addition, exosomes are natural content substances, have low immunogenicity, are not sensitized, and have strong capability of transmitting information among cells. The slow release and local administration can be realized by matching with the release of the gel substrate, and the physical barrier is given to the skin, so that the regeneration of skin tissues can be realized, and the scar tissue generation and skin pigmentation can be effectively improved.
Family members' experience of integrating chronic illnesses or chronic conditions into family life is valuable information for health care professionals, such as nurses, to understand, improve, and adjust the care provided to families of chronically ill patients. Furthermore, the assessment of the experience of integrating chronic illness into family life can support family nursing interventions and reduce suffering. This study aimed to adapt and psychometrically test a new Likert-type questionnaire on the experience of integrating pediatric chronic illness into family life (EICI-FLQ) in two European samples. A sample of 164 primary caregivers of children/adolescents with chronic illnesses/conditions in Iceland and another sample of 237 primary caregivers with children/adolescents with chronic illnesses/conditions in Portugal completed the online questionnaire. Exploratory factor analysis of the Icelandic sample yielded support for a one-factor solution with acceptable internal reliability (Cronbach's α = .866). Confirmatory factor analysis of the one-factor structure in the Portuguese sample indicated good model fit and similar internal reliability (Cronbach's α = .838). This instrument has good psychometric characteristics and is a promising tool for measuring the experience of integrating pediatric chronic illness into family life in clinical and research settings.
The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antidepressant. In a method aspect of the present invention, an antidepressant is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antidepressant to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antidepressant through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antidepressant; and, b) a device that forms an antidepressant containing aerosol from the composition, for inhalation by the mammal.
Naloxone/Diazoxide evaluation: Oral placebo (for diazoxide) 3 hours before the first hypoglycemic episode. Intranasal naloxone (4 mg NARCAN Nasal Spray) via a nostril twice during the first hypoglycemia episode; once at the start of insulin administration and again after one hour. Intranasal naloxone (4 mg NARCAN Nasal Spray) will again be given via a nostril twice during the second period of hypoglycemia; once at the start of insulin administration and again after one hour.
INTRODUCTION: The emergence of handheld ultrasound devices capable of connecting to cell phones or tablets heralds a significant advancement in medical technology, particularly within the field of obstetrics. These devices offer the promise of immediate bedside ultrasound examinations, potentially revolutionizing patient care by enabling fetal assessments in diverse settings.
MATERIAL AND METHODS: This prospective study aimed to validate the reliability of non-piezo, chip-based handheld ultrasound devices in clinical obstetric practice. Conducted in a university hospital obstetric ward, the study included 100 pregnant women between 17 and 41 weeks of gestation. Participants underwent ultrasound examinations using both conventional and portable point-of-care ultrasound (POCUS) devices to compare the accuracy in estimating fetal weight and other parameters, such as cardiac activity, fetal presentation, placental location, and amniotic fluid volume. The reliability and agreement between the devices were assessed using intraclass correlation coefficients, Bland-Altman plots, and Pearson correlation coefficients.
RESULTS: The results show a near-perfect agreement (0.98) and correlation (r = 0.98, p < 0.001) for estimated fetal weight and most biometry measurements between the two types of ultrasound devices, with slight deviations in head circumference and amniotic fluid index measurements. Subgroup analysis revealed variations in agreement and correlation rates with higher BMI and advanced gestational age, indicating areas for further refinement.
CONCLUSIONS: These findings affirm the high reliability of handheld ultrasound devices for basic obstetric ultrasound evaluations, supporting their integration into daily clinical practice. This technology improves the flexibility and immediacy of prenatal care, although further research is needed to optimize its application across patient populations and treatment settings.
Messages are automatically generated on a user device. Physiologic data generated from the sensing of one or more physiological parameters of a user is received. User-entered data for the user is received. Social-context data is received describing one or more other user is within social communication with the user. A determination is generated from i) the physiologic data, ii) the user-entered data, iii) the social-context data, iv) historical, archival, or prerecorded data that records at least one profile of historical data that an automated message should be sent to one or more user devices. The automated message is sent.
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56 of each cycle. Cycles repeat every 56 days in the absence of disease progression or unacceptable toxicity. Patients also undergo PET/CT or CT scans in week 1 of cycle 2 and at off treatment follow up prior to progression. Additionally, patients undergo blood sample collection, ECHO or MUGA on study.