anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Recruit and sequence breast cancer subjects in Guatemalan and US Hispanic populations. Identify optimum strategies to recruit Latin American and Hispanic women into genetic studies of breast cancer.
METHODS: We used targeted gene sequencing to identify pathogenic variants in 19 familial breast cancer susceptibility genes in DNA from unselected Hispanic breast cancer cases in the US and Guatemala. Recruitment across the US was achieved through community-based strategies. In addition, we obtained patients receiving cancer treatment at major hospitals in Texas and Guatemala.
RESULTS: We recruited 287 Hispanic US women, 38 (13%) from community-based and 249 (87%) from hospital-based strategies. In addition, we ascertained 801 Guatemalan women using hospital-based recruitment. In our experience, a hospital-based approach was more efficient than community-based recruitment. In this study, we sequenced 103 US and 137 Guatemalan women and found 11 and 10 pathogenic variants, respectively. The most frequently mutated genes were BRCA1, BRCA2, CHEK2, and ATM. In addition, an analysis of 287 US Hispanic patients with pathology reports showed a significantly higher percentage of triple-negative disease in patients with pathogenic variants (41% vs. 15%). Finally, an analysis of mammography usage in 801 Guatemalan patients found reduced screening in women with a lower socioeconomic status (p < 0.001).
CONCLUSION: Guatemalan and US Hispanic women have rates of hereditary breast cancer pathogenic variants similar to other populations and are more likely to have early age at diagnosis, a family history, and a more aggressive disease. Patient recruitment was higher using hospital-based versus community enrollment. This data supports genetic testing in breast cancer patients to reduce breast cancer mortality in Hispanic women.
PROBLEM TO BE SOLVED: To provide the subject new compound capable of being obtained under a mild condition in high yield by using a raw material easily available as an industrial raw material, and useful as an insecticidal agent or a microbicidal agent for agriculture or horticulture, or antimicrobial agent for medical care. SOLUTION: This new compound is a 1,3-thiazine derivative or a 1,3- selenazine derivative of formula I (X is S or Se; R is H, an alkyl, an alkenyl, an alkynyl, an aryl, a substituted phenyl, an alkoxy, an acyl or the like; R1 is H, hydroxy, an alkoxy, an alkenyloxy or the like; and R2 to R6 are each H, an alkyl, an alkenyl an alkynyl, an aryl or the like), e.g. 4-hydroxy-4- methyl-2-(4-methylphenyl)-4H-5,6-dihydro-1,3-selenazine. The compound of formula I is obtained by reacting a thioamide or a selenoamide of formula II (e.g. 4- methylselenobenzamide) with an α,β-unsaturated ketones (e.g. methyl ethyl ketone) in the presence of a catalyst.
This meta-analysis aimed to systematically review and analyze parental awareness of human papillomavirus (HPV) and its vaccine, as well as parental willingness of the HPV vaccine in China. The literature search selected studies that met the following criteria: study published between 2009 and 2023, study design involving parents with at least one child aged ≤ 18 years, sample sizes exceeding 300, availability of data on parental willingness of the HPV vaccine or sufficient information to calculate effect sizes, and studies published in either English or Chinese. Studies that did not meet one of the above points were excluded. From an initial pool of 660 papers, 33 studies were included, encompassing a total sample size of 92,802. The analysis revealed that the pooled awareness rates of HPV and the HPV vaccine among Chinese parents were 45.0% (95% CI: 36.1-54.0%) and 41.4% (95%CI: 30.7-52.5%), respectively. The overall parental willingness for vaccinating children against HPV was 61.0% (95% CI: 53.5-68.3%). Both parental awareness and willingness of the HPV vaccine in China were found to remain low when compared to other countries.
The participant is guided through the web-based sessions by minimum weekly contact with an experienced therapist (estimated ½ hour/week for 10 weeks). The therapist will motivate, answer questions and give feedback on written material and exercises.
The invention relates to a natural dandruff-removing and itching-relieving hair conditioner which is prepared, by weight, by olive oil, aloes, mint and lemon. The natural dandruff-removing and itching-relieving hair conditioner does not contain any chemical substances, is non-toxic and harmless, and cannot cause any damage to human health. The natural dandruff-removing and itching-relieving hair conditioner enables hair to be smooth and manageable, also removes dandruff and relieves itching, and enables the hair to be brilliantly black, soft, bright, but not oily, full of vigor and elasticity, and healthy. The natural dandruff-removing and itching-relieving hair conditioner is mild and natural in smell and not tangy, and a delicate fragrance lasts after the natural dandruff-removing and itching-relieving hair conditioner is used. The natural dandruff-removing and itching-relieving hair conditioner is easy to wash out, and the hair is not sticky. After the natural dandruff-removing and itching-relieving hair conditioner is used, the hair is light, natural and smooth, moisture of the hair is maintained, static is reduced, luster is increased, and the protective film is generated on the surface of the hair.
BACKGROUND: Gestational diabetes mellitus (GDM) is the most common complication of pregnancy, affecting an estimated 16.7% of live births worldwide, which translates to approximately 21 million cases annually. Although poor sleep quality is a prevalent concern in this population, most existing studies predominantly focus on the impact of sleep disorders on GDM, rather than directly assessing sleep quality in women diagnosed with GDM. This study aimed to investigate sleep quality and its associated factors specifically among women with GDM.
METHODS: We originally aimed to include 287 women with GDM; ultimately, 618 were invited, of whom 393 participated in the survey through a convenience sampling method at the obstetric clinics of four general tertiary hospitals in Chongqing, China, from June to August 2022. Data were collected utilizing sociodemographic characteristics, the Pittsburgh Sleep Quality Index (PSQI), the Sleep Hygiene Scale, and the Pregnancy-related Anxiety Scale (PrAS). We employed linear regression analysis to identify factors associated with sleep quality.
RESULTS: The PSQI score of participants was (5.83 ± 3.41). Notably, 43.77% of participants reported an actual sleep duration of less than 8 h per night, whereas 45.55% experienced poor sleep quality. Worrying during the day about your inability to fall asleep (β = 0.204, P < 0.01), body image concern (β = 0.159, P < 0.01), going to bed thirsty (β = 0.160, P < 0.01), educational attainment (β=-0.150, P < 0.01), avoidance (β = 0.124, P < 0.01), sleep disturbed by bed partner's sleep (β = 0.126, P < 0.01), and worrying as you prepare for bed about your inability to fall asleep (β = 0.137, P < 0.05) significantly affected the sleep quality of participants.
CONCLUSIONS: The study revealed a high prevalence of insufficient sleep duration and poor sleep quality among women with GDM, which was significantly influenced by inadequate sleep hygiene habits and pregnancy-related anxiety. These findings enhance our understanding of the factors affecting sleep quality in this population and underscore the necessity for healthcare professionals to timely identify sleep disorders. Implementing appropriate interventions, such as the development of educational programs focused on sleep hygiene and body image acceptance through cognitive behavioral therapy, could enhance the quality of care for women with GDM.
A 91-year-old man presented with a cutaneous left abdominal mass. The mass was longstanding (over 5 years) and slow-growing. Examination revealed a violaceous, multinodular, and exophytic non-tender mass surrounded by patchy erythema. Excisional biopsy was performed and revealed a nodular and cystic dermal proliferation of predominately basaloid cells with focal duct formation, surrounded by prominent hyalinized stroma. The superficial portion of the mass was identified as a nodulocystic hidradenoma. Along the deep aspect and in association with the benign hidradenoma, sheets of markedly atypical epithelioid cells invaded the surrounding tissue, consistent with malignant transformation. Perineural and lymphovascular invasion were seen among areas with anaplastic features. This case supports that some hidradenocarcinoma originates from benign counterparts, and as such, ample sampling is required to definitively exclude a more sinister diagnosis. Diagnostic, prognostic, histopathological, and molecular characteristics, and current knowledge limitations are briefly discussed.
gingival mucoperiosteal flaps are designed along the cleft margins and elevated medial and lateral mucoperiosteal flaps are generated from the cleft and the gingival sulcus of the teeth. To obtain adequate mobility of the posterior flap, the flap must be extended to the first or the second molar and back-cut up to the buccal sulcus while taking care not to injure the alveolar bone covering the roots of the teeth. These flaps are raised up to and around the piriform aperture, and then are separated from the nasal mucosa the palatal mucoperiosteal flaps along the cleft margins are then elevated from the palate. After complete exposure of all the bony clefts, the nasal lining of the nostril floor is approximated and sutured, and the palatal flaps are then turned back and sutured to make a soft-tissue pocket. Grafting of the defect is accomplished with cortical bone only from the chin the cortical shelf is prepared to be two layers perpendicular to each other the first one is parallel to the nasal floor and second one is continuous with buccal cortex of alveolar ridge then cancellous bone will be packed under these shelves and be compressed into the cleft defect to maximize the number of osteo-competent cells and the osteoid material per unit graft volume. When packing bone particles, it is better to create the maxilla and alveolar ridges and elevate the depressed nostril by appropriately supporting the nasal base and aligning the symmetry. The rest can then be covered with gingival mucoperiosteal flaps through tension-free transposition
This is a standard smoking cessation smartphone app using the latest evidence-based smoking cessation methods and behavior change theory. Subjects will be encouraged to set a quit date of 3 weeks, to allow comparison to experimental arm quit date.
Currently, the gold standard in measurement of portal hypertension is via measurement hepatic venous pressure gradient (HVPG). The HVPG has been shown to correlate with risk of clinical decompensation, development of varices, hepatocellular carcinoma, variceal bleeding, spontaneous bacterial peritonitis and mortality. The technique involves ultrasound guided puncture of the internal jugular vein, followed by passage of a balloon catheter from through the right atrium, IVC and right hepatic vein. The free hepatic vein venous pressure is then measured followed by the wedge balloon venous pressure. The HVPG is then calculated by subtracting the free hepatic venous pressure from the wedge balloon venous pressure. When HVPG is \>10mmHg, the risk of developing varices is increased. If \>12mmHg, then risk of variceal bleeding is increased. Mortality risk is increased when HVPG is \>16-20mmHg. Nevertheless, the technique is technically difficult and it may not be available even in tertiary medical centres \[8\]. Furthermore, it requires the use of ionic contrast and also has a low acceptance rate amongst patients.

The aim of the current study is to investigate the feasibility of EUS-PPGM using the novel device and correlate the risk of developing complications with the PPGM in patients that are suffering from chronic hepatitis.

Recently, the use of EUS-guided approach for measurement of portal pressure gradient (PPGM) has been shown to be feasible. PPGM by the EUS approach was found to have excellent accuracy and strong correlation with pressure values obtained by the criterion standard transjugular wedged and free hepatic venous pressure measurements by interventional radiology in an animal model. Furthermore, in a pilot study involving 29 patients. The technical success rate was 100% and no adverse events were reported. Measurements obtained with the EUS approach was shown to correlate excellently with clinical parameters of portal hypertension including presence of varices, portal hypertensive gastropathy and thrombocytopenia. Furthermore, the procedure could be performed at the same time of screening oesophagogastroduodenoscopy (OGD), that is frequently required for variceal screening in this group of patients. However, whether the technique could reproduce results similar to HVPG in humans is uncertain.
The aim of the study is to evaluate the impact of preoperative breast MRI on primary surgical treatment in a highly specialized multidisciplinary breast cancer clinic. The clinic serves a population of 237.000. The diagnostic tools routinely used are conventional mammography, ultrasound with core needle biopsy, and clinical examination including palpation of breast and axillary nodes. If indicated, the examination includes ultrasound examination and fine needle biopsy of axillary glands. We offer all patients selected for breast-conserving surgery preoperative breast MRI.

We include consecutively breast cancer lesions in women aged 35-75 in a prospective study, collecting data from January 2009 to December 2010. The patients are all selected for breast-conserving surgery based on the criteria recommended by the Norwegian Breast Cancer Group. That is, tumor ≤ 4 cm, or acceptable tumor:breast ratio, and age \> 35. Multifocal lesions, defined as more than one tumor \> 1 cm apart, size of tumor \> 4 cm, or a large tumor:breast ratio, extensive ductal carcinoma in situ (DCIS), or known genetic disposition for breast cancer, indicates mastectomy according to these criterias. In addition, when postoperative radiation therapy is contraindicated, mastectomy is indicated. If the patients fill the criteria for breast-conserving surgery, they are offered preoperative breast MRI and included in the study. Patients who either choose mastectomy, or does not get a breast MRI for technical reasons, are excluded from the study. Two experienced breast radiologists evaluate the breast MRIs, and three experienced breast radiologists study the mammographies and perform the ultrasound examinations and biopsies. All additional MRI findings are examined by ultrasound-guided biopsy and given a histological diagnose before it influence the surgical method.

A formal application has been presented to the regional ethical commitee. Since this is an observational study of established practice, the commitee replied that approval was not required.
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to the pharmaceutical industry. Disclosed is an isotonic infusion solution for perioperative fluid therapy. The solution contains ions of sodium, potassium, calcium, magnesium, chlorine, acetate, malate, glucose and water with a ratio of the malate ion to glucose of 1/11 and a ratio of the malate ion to the potassium ion of 1/0.76 - 1/0.42. The components are taken at a certain concentration. The osmolarity of the solution without glucose is 290.6-323.2 mmol/L.EFFECT: above solution is used to prevent hypo- and hypernatremia, to maintain the level of carbohydrate metabolism at a sufficient level, to provide protection against possible hypoxia. The solution is characterized by high stability. It has an antihypoxic effect and is effective when used for perioperative replacement of blood, electrolyte and fluid losses with partial coverage of a patient's need for carbohydrates. The invention ensures stabilization of carbohydrate metabolism in the perioperative period.1 cl, 7 tbl
Systems and methods are provided for detecting physiological episodes (PE). Raw physiological data including raw respiration data is received from at least one sensor of a biosensing garment of a pilot. Individual breaths are extracted from the raw physiological data. Each individual breath has an associated breath pattern. Aircraft environment data associated with an aircraft is received. The individual breaths are aligned with the aircraft environment data in accordance with a breath timeline associated with the individual breaths is and an aircraft environment timeline associated with the aircraft environment data. Each individual breath is classified as one of a plurality of different breath types based on the associated breath pattern. A determination is made regarding whether the breath types associated with the individual breaths are associated with a PE profile based at least in part on the aircraft environment data. A PE alert is issued based on the determination.
This is a Clinical crossover trial study. In this study, 100 patients with type II diabetes will be selected based on entry and exit criteria, then randomly divided into two equal groups (group "A" and group "B").In the first three days of the first week of hospitalization, in group "A" insulin injection with a 90-degree angle and using Nidel 32-Gauge with a length of 5 mm, and in the other group insulin injection with a 90-degree angle and using Nidel 32-Gauge with a length of 8 mm will be done. After a one-day break, in another three days, the types of needles used in the two groups are moved together. After a one-day break, in another three days, the types of needles used in the two groups are replaced together. Then the VAS scale will be used to assess post-injection pain; the amount of leakage after the injection will be measured in two ways Yes/No, according to the researcher's observation. And to check the effect of Needles on controlling patients' blood sugar, their blood sugar levels will be measured based on the routine of hospital units.

After entering the data in SPSS20 software, the collected data will be analyzed using descriptive statistics (frequency, percentage, mean, standard deviation) and statistical tests (t-test, chi-square).
Frequency: Twice daily (morning and evening) Dosage Form: Tablets Dosage: 9 tablets for BID on Day 1 + 4 tablets BID for next 9 days (maximum). On Day 1, the second dose will be administered with at least a 4-hour interval from administration of the first dose.
The invention discloses a Hydrangea strigosa capable of preventing and treating a heat syndrome, cold and cough, and belongs to the technical field of Chinese herbal medicine processing. The Hydrangea strigosa is prepared from Ampelopsis grossedentata, buerger pipewort flower, Adenosma glutinosum Druce, rose mallow root, rhoeo discolor,an EMoriginal liquid and the like. The buerger pipewort flower and the Adenosma glutinosum Druce as main medicines are good at expelling wind and dissipating heat, dispelling wind-damp, eliminating pyogenic infections and promoting qi and blood so as to dissipate excessive heat of cold, the buerger pipewort flower can clear and dispel toxic heat to treat a headache and a throat disease caused by a cold, and the Adenosma glutinosum Druce can dispel wind and promote qi to relieve the pain caused by stagnation of a cold. The Ampelopsis grossedentata is mainly used for treating a cold, fever, sore throat and swelling and pain of eyes and has internal heat eliminating and sweating, anti-inflammatory and analgesic effects. The medicines are compatible to form a core medicine for treating a heat-syndrome cold. The rose mallow root and the rhoeo discolor can dispel wind and promote dampness, clearlung and eliminate phlegm, and detoxify and relieve pain and can mainly treat a lung heat cough and asthma, and are suitable for treating a heat-syndrome cold and cough. The rose mallow root can activate blood, dredge collaterals and dissipate blood stasis, tonify qi and spleen, and strengthen healthy qi to eliminate pathogens to treat the cold disease.
The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences (events) reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the terazosin group was at least 5%, where the prevalence rate for the terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest. Asthenia, blurred vision, dizziness, nasal congestion, nausea, peripheral edema, palpitations and somnolence were the only symptoms that were significantly (p < 0.05) more common in patients receiving terazosin than in patients receiving placebo. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials.

  


Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. The following additional adverse reactions were reported by at least 1% of 1987 patients who received terazosin in controlled or open, short- or long-term clinical trials or have been reported during marketing experience:
The solubility and stability of basic pharmaceuticals (I) in mixts. of mono- an di-glycerides of 6-12C fatty acids are improved by adding to (I) free 6-18C (6-10C) fatty acids. The resulting salts are then dissolved in the glyceride mixt. Better resorption of (I) from the gastro-intestinal tract. The fatty acid salts of (I) are more soluble in the glyceride mixt. than free bases or hydrochlorides.
PURPOSE: A protein conjugate containing oxyntomodulin and immunoglobulin Fc region and a pharmaceutical composition containing the same for preventing or treating obesity are provided to promote adipose decomposition and to safely and effectively treat obesity. CONSTITUTION: A conjugate contains oxyntomodulin and immunoglobulin Fc region which are conjugated by non-peptidal polymers. The oxyntomodulin has an amino acid sequence of sequence number 1. The oxyntomodulin is an oxyntomodulin derivative prepared by addition, deletion, or substitution of wild type oxyntomodulin. The both ends of the non-peptidal polymers are conjugated to an amine group or a thiol group of the immunoglobulin Fc region and oxyntomodulin. A pharmaceutical composition for preventing or treating obesity contains the conjugate. The pharmaceutical composition is administered solely or is combined with other pharmaceutical formulation for prevent or treating obesity.
This is an open label, prospective study to evaluate safety and efficiency of Silk'n Glide on the face. During the study, the subjects will perform up to 6 face treatments, two weeks apart. The treatment's safety and efficiency will be evaluated at 4 weeks of after last treatment and at 12 weeks after last treatment .
Control 4: Hand cleaning for 60 seconds with a clean Supertowel. The Supertowel will be soaked in water by submersing it completely in a bucket filled with tap water. The amount of water absorbed by the ST will be recordedby means of weighing the Supertowel before and after soaking. The control group will clean their pre-contaminated hands of with thesoaked Supertowel for 60 seconds.