anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Echocardiography is currently the technique of choice to assess the etiology and severity of mitral regurgitation (MR). Multiple 2D and Doppler parameters are assessed in an integrated fashion and the proximal flow convergent zone of the mitral regurgitation jet is used to calculate effective regurgitant orifice area and regurgitant volume. These measurements have been shown to have important prognostic information. In the last two years, the development of transesophageal imaging with 3D capability has allowed a better visualization of mitral leaflet pathology. Color Doppler 3D studies have shown that 2D methods generally underestimate mitral regurgitant volume. Magnetic resonance techniques have recently been developed to quantitate flow and calculate regurgitant volumes.

The purpose of this study is to evaluate newer methods of quantitating mitral regurgitation severity using real-time 3D echocardiography (RT3DE) and cardiac magnetic resonance imaging (CMR). Although RT3DE measurements have been shown to correlate well with CMR measures of LV volumes, using a 3D volumetric method to calculate mitral regurgitant volumes has not been well studied. In patients with more than mild mitral regurgitation, we will obtain transthoracic RT3DE measures of mitral regurgitant volume and compare them with traditional 2D measures of MR severity. We will also compare RT3DE and CMR measures of mitral regurgitant volume.
Researchers desire to capture the behaviors and outcomes of those individuals who would enroll in these programs without the additional encouragement to be a participant in a research study. The study will employ an observational prospective design intended to introduce as little interference as possible with subjects' behaviors. This is in order to capture the pure effects of the weight-loss programs themselves, and to reduce the potentially confounding effects of merely participating in a research study. Subjects who have already committed to a weight-loss program (Medifast Direct, Take Shape For Life , or other) will be recruited to join this study, and will be asked to complete several questionnaires over a period of up to 6 ⅓ years after enrollment. Questionnaires will measure information regarding anthropometrics, sociodemographics, and health \& quality of life outcomes. The overall goal of this research is to be able to describe and compare the long-term dieting behaviors and outcomes among participants in Medifast Direct and Take Shape For Life programs in comparison with other dieters.
ON101 cream will be applied twice daily for up to 20 weeks to the Target Ulcer. The SOC will include evaluation to ensure adequate blood flow, wound cleaning, removal of necrotic, infected and/or nonviable tissue by debridement, maintenance of a moist wound environment via regular dressing changes, and management of infection through oral antibiotics, if necessary.
Emulsion comprising 0.01-85% silicone, 0.01-35% of a hydrophobic and/or hydrophilic emulsifier, 0.1-99% of a biocompatible salt solution and 0.01-40% dimethyl sulfoxide is used for treating diseases resulting from the accumulation of harmful metabolites or from the inability of an organism to react to strong life-preserving internal and external stimuli, or to neutralize or buffer pathogenic concentrations of reactive oxygen intermediates. Emulsion comprising 0.01-85% silicone, 0.01-35% of a hydrophobic emulsifier with a hydrophilic-lipophilic balance (HLB) of 1-7 and/or a hydrophilic emulsifier with an HLB of 7-14, 0.1-99% of a biocompatible salt solution and 0.01-40% dimethyl sulfoxide is used for treating or preventing diseases resulting from the accumulation of harmful metabolites or from the inability of an organism to react to strong life-preserving internal and external stimuli and/or to neutralize or buffer pathogenic concentrations of reactive oxygen intermediates in the metabolism of animals and humans. ACTIVITY : Virucide; Anti-HIV; Antiinflammatory; Antiulcer; Antiparkinsonian; Neuroprotective; Nootropic; Antibacterial; Antiasthmatic; Nephrotropic; Uropathic; Antimigraine; Antirheumatic; Antiarthritic; Cytostatic; Vasotropic; Hypotensive; Analgesic; Relaxant; Dermatological; Vulnerary; Muscular-Gen; Immunomodulator. A patient due to undergo dental surgery to insert titanium implants into the lower jaw was treated with 2.5 ml of the emulsion (composition and administration route not stated) before the procedure. There was only slight pain after the local anesthetic wore off. Repeated application of the emulsion made the patient free of pain. Slight pain occurring after 2 days was relieved by further application of the emulsion. The implant sites healed without complications. MECHANISM OF ACTION : Oxygen radical scavenger.
The invention relates to a formula and a preparation method of a pollen product. The pollen product is prepared according to principles that bee pollen has the function of treating prostate and pumpkinseed has pharmacological effects of easing the prostatitis and treating nonmalignant prostate hypertrophy. In the formula disclosed by the invention, pumpkinseed powder is used as a raw material based on bee pollen, wherein the bee pollen accounts for 80 percent by weight, and the pumpkinseed powder accounts for 20 percent. The invention also discloses a preparation method of the product, which adopts the high-quality natural pollen and pumpkinseed and the scientific formula. The pollen product is rich in various kinds of protein, amino acid, vitamins, flavonoids, trace elements and biological active substances, and is a nutritional product which can help improve prostatic disorders. The modern medical research and clinical practice show that the pollen has specific effects on treatment of the chronic prostatitis, functional disorders of the prostate and the prostate hypertrophy, and is incomparable with certain drugs.
Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is a cytotoxic drug. Follow applicable special handling and disposal procedures.1 The use of gloves is recommended. If Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) (lyophilized cake or reconstituted suspension) contacts the skin, wash the skin immediately and thoroughly with soap and water. Following topical exposure to paclitaxel, events may include tingling, burning, and redness. If Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) contacts mucous membranes, the membranes should be flushed thoroughly with water.

Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) is supplied as a sterile lyophilized powder for reconstitution before use.

Read the entire preparation instructions prior to reconstitution.

Each mL of the reconstituted formulation will contain 5 mg/mL paclitaxel.

The reconstituted suspension should be milky and homogenous without visible particulates. If particulates or settling are visible, the vial should be gently inverted again to ensure complete resuspension prior to use. Discard the reconstituted suspension if precipitates are observed. Discard any unused portion.

Calculate the exact total dosing volume of 5 mg/mL suspension required for the patient and slowly withdraw the dosing volume of the reconstituted suspension from the vial(s) into a syringe: Dosing volume (mL)=Total dose (mg)/5 (mg/mL).

Inject the appropriate amount of reconstituted Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) into an empty, sterile intravenous bag [plasticized polyvinyl chloride (PVC) containers, PVC or non-PVC type intravenous bag]. The use of specialized DEHP-free solution containers or administration sets is not necessary to prepare or administer Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) infusions. The use of medical devices containing silicone oil as a lubricant (i.e., syringes and intravenous bags) to reconstitute and administer Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) may result in the formation of proteinaceous strands.

Visually inspect the reconstituted Paclitaxel Protein-Bound Particles for Injectable Suspension (Albumin-Bound) suspension in the intravenous bag prior to administration. Discard the reconstituted suspension if proteinaceous strands, particulate matter, or discoloration are observed.
Participants completed all tasks of the IMP group and additionally, individuals in the IMP+ condition received fluency training and text message reminders. Fluency training occurred weekly using an online survey tool. On fluency training days, participants received a survey link via email, which consisted of six multiple-choice questions for participant's unique implementation intentions. Participants had to correctly identify their matching goal-aligned behavior among three distractor behaviors as quickly as possible and were given corrective feedback if they chose incorrectly. Text messages containing all six implementation intentions as well as goal reminders that were obtained by asking participants to write down their reasons for wanting to lose weight were sent on four days each week of the intervention (16 days total). At baseline, participants chose how text messages were bundled and when they were sent. Text schedules stayed constant across the study.
Neurolymphomatosis (NL) is a rare complication of non-Hodgkin's lymphoma, characterized by the infiltration of lymphoma cells into the peripheral nerves. A 54-year-old woman initially presented with right facial palsy without any other significant symptoms and was diagnosed with Bell's palsy. Despite initial improvement, her condition recurred, prompting further evaluation. Magnetic resonance imaging (MRI) revealed contrast enhancement from the tympanic segment to the surface of the masseter muscle along the right facial nerve and an adjacent mass lesion. Biopsy of the mass revealed a diagnosis of T-cell/histiocyte-rich large B-cell lymphoma. Chemotherapy resulted in complete resolution of facial palsy. Follow-up MRI confirmed the absence of contrast enhancement along the facial nerve. Facial palsy was considered to be caused by NL. This case was classified as that of primary NL because the facial palsy was the first manifestation of a hematologic malignancy. Recurrent facial palsy, which is atypical in Bell's palsy, led to further evaluation with MRI, which finally resulted in the diagnosis of malignant lymphoma. In cases of recurrent facial palsy, clinicians should consider various diagnoses, including that of NL, and advocate early imaging tests and biopsy, if possible, for accurate diagnosis and improved outcomes.
Patients in the Triamcinolone group will be applying Triamcinolone 0.1% cream daily to their face, chest, and upper back, in addition to adhering to the same daily moisturizer and sunscreen regimen of the Control group. Erlotinib, cetuximab, panitumumab, or afatinib will be administered concomitantly as standard of care treatment.
An automatic labeling method for an antinuclear antibody fluorescent karyotype belongs to the research field of medical big data processing. Due to the difficulty in collecting labeled antinuclear antibody fluorescent karyotype pictures, it is difficult to learn a brand new fast-RCNN network structure from the beginning with a small amount of samples. The first step of the method is to select a common pre-training model as an initial network according to the characteristics of the picture to be identified. And secondly, comparing the requirements of the pre-training model on the input picture with the collected training sample examples, and performing picture preprocessing work, specifically comprising cutting, labeling, naming and the like. And the third step is to train the fast-RCNN with the initialized network through the training samples obtained in the previous step, and determine real-time parameters through iterative optimization. After a proper Faster-RCNN model is obtained, the fourth step of the method can be used for carrying out identification and marking of the newly added picture, and the newly added picture also needs to be subjected to necessary preprocessing, such as cutting.
PCT No. PCT/FR92/00494 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed Jun. 4, 1992 PCT Pub. No. WO92/21322 PCT Pub. Date Dec. 10, 1992The invention relates to the use of an extract of prunella or at least one prunella saponin. This extract or this saponin is used for the preparation of a cosmetic or pharmaceutical and/or dermatological composition. Said composition makes it possible to regulate the renewal and differentiation of the keratinocytes and has an anti-aging activity, an anti-inflammatory activity, especially in inflammations caused by ultraviolet radiation, or an anti-allergic or anti-free-radical activity. It also enables the epidermis of normal skin to be kept in good condition, especially by maintaining the functional role of the skin, in particular as a protective barrier, and makes it possible to prevent or treat dry skin, especially ichthyotic skin, and to treat psoriasis.
BACKGROUND: It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome (MetS), causes changes in the gut microbiota and metabolic disorders. There is limited knowledge on the effects of metformin in HF-induced intestinal irregularities in male and female rats with MetS.
OBJECTIVES: In this study, we investigated the sex-dependent effects of metformin treatment on the gut microbiota, intestinal Tight Junction (TJ) proteins, and inflammation parameters in HF-induced MetS.
METHODS: Fructose was given to the male and female rats as a 20% solution in drinking water for 15 weeks. Metformin (200 mg/kg) was administered by gastric tube once a day during the final seven weeks. Biochemical, histopathological, immunohistochemical, and bioinformatics analyses were performed. Differences were considered statistically significant at p < 0.05.
RESULTS: The metformin treatment in fructose-fed rats promoted glucose, insulin, Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR), and Triglyceride (TG) values in both sexes. The inflammation score was significantly decreased with metformin treatment in fructose-fed male and female rats (p < 0.05). Moreover, metformin treatment significantly decreased Interleukin-1 Beta (IL-1β) and Tumor Necrosis Factor-Alpha (TNF-α) in ileum tissue from fructose-fed males (p < 0.05). Intestinal immunoreactivity of Occludin and Claudin-1 was increased with metformin treatment in fructose-fed female rats. HF and metformin treatment changed the gut microbial composition. Firmicutes/Bacteroidetes (F/B) ratio increased with HF in females. In the disease group, Bifidobacterium pseudolongum; in the treatment group, Lactobacillus helveticus and Lactobacillus reuteri are the prominent species in both sexes. When the male and female groups were compared, Akkermansia muciniphila was prominent in the male treatment group.
CONCLUSION: In conclusion, metformin treatment promoted biochemical parameters in both sexes of fructose-fed rats. Metformin showed a sex-dependent effect on inflammation parameters, permeability factors, and gut microbiota. Metformin has partly modulatory effects on fructose-induced intestinal changes.
This is Fudekang foam agent and its preparing method, and its characteristic is: it is made from kuh-seng alkaloids dodesyl sodium sulfate, doctacosanol, wool alcohol, water and other raw materials. Its manufacturing technique is: dissolve kuh-seng alkaloids in water, adjust pH value with hydrochloric acid, and unfreeze dodesyl sodium sulfate, doctacosanol and wool alcohol on water bath; mix the two liquids and agitate homogeneous, then add distilled water to the total amount and agitate homogeneous, instead of pouring it into voltage-withstand vessel and adding propellant, this invention pour it into pressure net foam latex generator, which can generate foam when pressing its foam latex pump. Using pressure net foam latex generator, generating foam by pressing a foam latex pump can save cost, reduce environmental pollution caused by propellant, reduce pressurized vessel easy-burst and make it safer. The foam agent can make medicine distribute even and broad in vagina cavity or on skin surface, make the medicine filter into vagina mucosa crink-wall. It has characteristics of therapeutic effect volatilization plenty and quick, therapeutic effect good, health, safety and convenient. It is a perfect medicine for curing colpitis mycotica, uterus neck erosion, and other gynecological pathology diseases.
The present invention involves a method of preparing Mirabilitum Praeparatum by pure strain fermentation and its application in treating infectious and inflammatory diseases, as well as health products and cosmetics. The method involves blending the ripe fruit (watermelon) of Citrullus Ianatus (Thunb.) Matsum. et Nakai with mirabilitum (Na2SO4.10H2O) according to a certain ratio as culture media and the pure strain Penicillium rubens as zymocyte, and then fermenting under a certain temperature. The Mirabilitum Praeparatum prepared by present method is different from that of prepared by traditional technology significantly, and the present invention possesses more advantages than the traditional method. The Mirabilitum Praeparatum prepared by present method, its extract shows powerful antibacterial and anti-inflammatory activities, which can be prepared into pharmaceutical preparations to treat infectious diseases of mucous membrane and skin, such as cavum oris ulcer, paradentosis, glossitis, rhinitis, laryngopharyngitis, dermatitis, otitis media, uterine cervicitis, kysthitis, and other health products and cosmetics.
The application discloses a method for improving antiviral efficacy of rainbow trout I-type interferon alpha protein, and belongs to the technical field of medical drugs. The method comprises the following steps: adopting resistant starch and carboxymethyl chitosan as microencapsulation materials to carry out microencapsulation treatment on interferon alpha protein. The application adopts a novel combination mode of coating materials: resistant starch-carboxymethyl chitosan, wherein, resistant starch has excellent enzymolysis resistance and colon targeting, and can prolong the half-life of interferon protein in vivo. And the carboxymethyl chitosan has excellent water solubility and film forming property. The highest encapsulation rate of the two composite materials can reach 23.09%, the highest drug loading rate can reach 81.20%, and the effect is remarkable. The oral interferon microcapsule prepared by emulsification by the method has simple use method, obvious antiviral effect and excellent application prospect, and provides a new idea for microencapsulation coating.
Period 1-Test Treatment: Ovine enoxaparin sodium 60 mg SC injection, manufactured by Metiska Farma. Period 2-Reference Treatment: Porcine enoxaparin sodium 60 mg SC injection (Lovenox), manufactured by Sanofi, France.
Participants will take sertraline that is dosed between 50 and 100 mgs during the symptomatic period. Women who report moderate to severe side effects will be allowed to reduce their dose to 25 mg of sertraline and to increase the dose at the next cycle unless rate-limiting side effects continue.
PCT No. PCT/EP93/02367 Sec. 371 Date Mar. 6, 1995 Sec. 102(e) Date Mar. 6, 1995 PCT Filed Sep. 2, 1993 PCT Pub. No. WO94/05331 PCT Pub. Date Mar. 17, 1994The present invention relates to stable highly concentrated formulations of specific fluorescein derivatives, to the preparation of said formulations and the use thereof, especially for the photodynamic therapy of secondary cataract. The invention principally relates to an aqueous solution comprising a fluorescein diester, preferably a fluorescein di-lower alkyl ester, most preferably fluorescein diacetate, and a partially etherified  beta -cyclodextrin the ether substituents of which are hydroxyethyl, hydroxypropyl or dihydroxypropyl groups, some of which ether substituents may be methyl or ethyl groups, said  beta -cyclodextrin ether having a water-solubility of more than 1.8 g in 100 ml of water, preferably hydroxy- beta -cyclodextrin.
Purpose: To investigate the efficacy of a training program including resistive action video games on functional fitness (FF) of disabled workers in sheltered workshops (DWSWs).

Material and methods: Thirty-two DWSWs participated in this study and were allocated as either experimental group (EG) or control group (CG). DWSWs in EG underwent three 60-minute training sessions each week for 12 weeks. One of the session is group training and two of the sessions are individual session. In group session, the participants do aerobic exercise following a video which was launch by the health management ministry of city government. In the individual session, the participants play play two video games alternatively. The video games used are Fitness Boxing 2 and Adventure Ring-Fit. In addition to the training program, the participants in the EG maintain work and leisure routine in addition to the added training. The participants in the CG maintained daily work and leisure routine.The outcome measures included body mass index, body weight, body fat percentage, skeletal muscle rate, muscle strength, cardiopulmonary endurance, flexibility, balance and agility. All participants must be evaluated of the outcome measures at pre-, mid- and post-training time point.
New strategy - Patients benefit from a 3D rotational acquisition at the end of procedure, which offers CT-like reconstructions. If any technical issues is depicted on the 3DRA, it can be treated during the same operating time. A contrast-enhanced ultrasound is performed for each patient before discharge to confirm that no technical issue was missed by the 3DRA.
The patients of this arm practice on-line muscle relaxation every day.They complete the Brief Symptom Rating Scale(BSRS), Family APGAR(APGAR), the Chinese-version of the Medical Outcomes Study 36-Item Short Form Health Survey(SF-36), and the panic diary via internet browser. The Panic Disorder Severity Scale(PDSS)and Clinical Global Impression (CGI) were performed by well-trained clinicians.