anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Intervention activities included helping participants to open savings accounts at a local federal credit union with 1:1 matches of up to twenty dollars per month for 12 months. Participants also received financial empowerment and Peer Support curriculum, weekly for about 3 hours per week for 28 weeks.
The invention relates to brain-clearing and heart-nourishing traditional Chinese medicine liquor which is prepared by the following superior traditional Chinese medicines: rhizoma gastrodiae, suncured ginseng, American ginseng, the fruit of Chinese magnoliavine and ginseng under forest. A preparation method is as follows: firstly cold soaking the superior traditional Chinese medicines into 2500-7500ml of pure grain liquor with alcohol degree of 42 and drinking the liquor after soaking for 100 days. The liquor is drunk once a day, 15ml every time or is drunk twice a day, 10ml every time. Before drinking the liquor, the patients can eat hawthorns, tea water and radishes are forbidden in one hour before or after drinking the liquor, but hawthorns can be eaten. The liquor can tonify qi in five viscera, activate meridians and collaterals, dredge microcirculation, maintain blood supply balance, strengthen blood supply in myocardium, reduce myocardial oxygen consumption, strengthen blood supply in brain issues, prevent cardiovascular and cerebrovascular diseases and correct yin and yang of human body and disorder of qi and blood. The liquor has the advantages of using corrigent or mitigating the properties of the bitter cold medicines, promoting gastrointestinal secretion of human body, helping digestion and absorption, improving blood circulation, promoting tissue metabolism and strengthen cell vitality.
The time management program aims to examine the effectiveness of an intervention strategy designed to increase personal and work outcomes through the strengthening of time management characteristics. The time management intervention (delivered over four weeks) will ask study participants to use the time management version of the app each week, with specific instructions on selecting one section each week and first listening to the longer version and reflect. At least two other times during the week they will be asked to listen to a recording of their choice on the same topic. On the final week (week 5) all participants (experimental and control) will return to the lab to complete post-study assessment tools (SART, post-study on-line questionnaire, provide a urine sample, and weight measurement).
This disclosure relates to systems and methods for managing patients of knee surgeries. A pre-operative patient questionnaire user interface is associated with a future knee operation of the patient. Patient input data is indicative of answers of a patient in relation to the pre-operative patient questionnaire. A processor of a computer system evaluates a statistical model to determine a predicted satisfaction value indicative of satisfaction of the patient with the future knee operation. The statistical model comprises nodes stored on data memory representing the patient input data and the predicted satisfaction value, and edges stored on data memory between the nodes representing conditional dependencies between the patient input data and the predicted satisfaction value. The processor then generates an electronic document comprising a surgeon report associated with the future knee operation to indicate to the surgeon the predicted satisfaction value.
In Part B, Group 4 will receive 4 vaccinations of either the DNA vaccine EP-HIV-1090 or placebo. Vaccinations will occur at Months 0, 1, 3, and 6.
The invention relates to a preparation method of a medicine controlled release microcapsule used for the field of medicine and bioengineering. Calcium alginate serves as gel beads. Polylysine serves as the capsule wall. The microcapsule is prepared through a static combination method. Meanwhile, polylysine is used as a film formation material used for preparing the calcium alginate/polylysine medicine controlled release microcapsule, and the calcium alginate/polylysine medicine controlled release microcapsule which is uniform in particle size, allows the particle size to be controlled within the range of 300-900 micrometers and is smooth in surface can be prepared with the help of a high voltage static drop generation device and through calcium alginate external gelatinization and polylysine film formation. Due to the fact that polylysine and degraded products of polylysine have pharmacology functions, a drug carrier with an interventional therapy effect can be obtained, and the calcium alginate/polylysine medicine controlled release microcapsule is used for embedding medicine or cells and used for the field of food and bioengineering.
INTRODUCTION: During laparoscopic surgery, surgeons may experience prolonged periods without fluid intake, which might impact surgical performance, yet there are no objective data investigating this issue. Therefore, the aim of this study was to elucidate the effect of prolonged dehydration on laparoscopic surgical performance and tissue handling.
METHODS: A total of 51 laparoscopic novices participated in a single-center, open-label, prospective randomized cross-over trial. All participants were trained to proficiency using a standardized laparoscopic training curriculum. Afterward, all participants performed four different laparoscopic tasks twice, once after 6 h without liquid intake (dehydrated group) and once without any restrictions (control group). Primary endpoints were tissue handling defined by force exertion, task time, and error rate. The real hydration status was assessed by biological parameters, like heart rate, blood pressure, and blood gas analysis.
RESULTS: 51 laparoscopic novices finished the curriculum and completed the tasks under both hydrated and dehydrated conditions. There were no significant differences in mean non-zero and peak force between the groups. However, dehydrated participants showed significantly slower task times in the Peg transfer task (hydrated: 139.2 s vs. dehydrated: 147.9 s, p = 0.034) and more errors regarding the precision in the laparoscopic suture and knot task (hydrated: 15.7% accuracy rate vs. dehydrated: 41.2% accuracy rate, p < 0.001).
CONCLUSION: Prolonged periods of dehydration do not appear to have a substantial effect on the fundamental tissue handling skills in terms of force exertion among surgical novices. Nevertheless, the observed impact on speed and precision warrants attention.
Choristomas are proliferative growths that occur when normal tissue develops in abnormal locations and may resemble tumors. Oral choristomas commonly present as slow-growing, indolent, and firm masses. The diagnosis primarily relies on histopathologic examination. Given their tumor-like growth and developmental pathogenesis, it is critical to differentiate them from neoplasms. In this article, we present two clinical cases of oral choristomas, a cartilaginous choristoma, and an osseous choristoma of the tongue. We also offer a brief review of the literature discussing clinical presentation, microscopic features, and therapeutic options.
The receptor for Interleukin 35 (IL-35) is provided. The Interleukin 35 Receptor (IL-35R) comprises a heterodimeric complex of the Interluekin12Rβ2 receptor and the gp130 receptor. Various compositions comprising the IL-35R complex, along with polynucleotides encoding the same and kits and methods for the detection of the same the same are provided. Methods of modulating the activity of IL-35R or modulating effector T cell functions are also provided. Such methods employ various IL-35R antagonists and agonists that modulate the activity of the IL-35R complex and, in some embodiments, modulate effector T cell function. Further provided are methods for screening for IL-35R binding agents and for IL-35R modulating agents. Various methods of treatment are further provided.
PURPOSE:A composition for exodermis administration for raising drug permeability through skin and endermic absorption, containing a specific ester as an essential component. CONSTITUTION:A composition for exodermis administration having raised endermic absorption, containing an ester shown by the formula I (ring A is 5-7- membered ring; R is 5-13C chain hydrocarbon residue; p=0 or 1; X is H, lower alkyl, halogen, etc.,) as an essential component. Further addition of a polar compound to the composition raises synergistically endermic absoption of drug. A lower alcohol, glycerin, a cyclic urea shown by the formula II (R1 and R2 are H or lower alkyl) are preferable as the polar compound. The amount of the ester shown by the formula I blended is preferably 1-50wt% based on total amounts of the polar compound and the ester shown by the formula I. The composition raises permeability of a drug administrable to exodermis through the skin and endermic absorption and is readily administered to body.
Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, and mydriasis. Fatigue and depression usually follow the central stimulation.

Cardiovascular effects include tachycardia, arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Overdose of pharmacologically similar compounds has resulted in convulsions, coma and death.

The reported oral LD 50 for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg. 

Management of acute diethylpropion hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Intravenous phentolamine has been suggested on pharmacologic grounds for possible acute, severe hypertension, if this complicates diethylpropion hydrochloride tablets, 25 mg overdosage.
The present invention relates to a kind of medicine for treating tumor, it features broad spectrum, high effect, low toxicity, and side effect free. It can also treat rheumatic disease, rheamatoid disease, hemorrhoid, varicosis, and possesses of the actions of anti-inflammation, analgesia, and obstention from smoking. The structural formula is 1,1,7-trimethyl dicyclo [2,2,1]-2-heptanol-5-methyl-2-isopropyl cyclohexanol called antitumor terpine I (formula A) in short, and 1,1,7-trimethyl dicyclo [2,2,1]=2heptanone-5-methyl-2-isopropyl cyclohexanol, called antibumor terpine II (formula B) in short. The arbitrary mixture of A and B is called the anti tumor terpine I, II mixture. The technological characteristic lies in that it can detect two or three ingredients of the composition simultaneously and possessing the special fragrance. It can make into various forms of the drug, beverage and candy. The initial raw material is abundant and capable of regenerating.
FIELD: veterinary virology. SUBSTANCE: method involves immunization of donor-animals (sheep, goats) firstly with cultural viral antigen by subcutaneous route with noncomplete and complete Freund's adjuvant and then with antigen no containing Freund's adjuvant at a single dose at all immunization stages (10: 25) ml and at antigen titer 5 lg LD 50 ,, not less. Blood samples are taken from donors at regular intervals at blood antibody titer 2.5 lg, not less, in reaction of biological neutralization for plague viruses or carnivorous adenoviral hepatitis and at 1:512, not less, in suppression hemagglutination reaction for parvoviral enteritis. Then animals are subjected for the periodical repeated vaccination at the same titer and dose of antigen but without Freund's antigen. Immunoglobulins are isolated by precipitation with salts followed by purification using the preparative chromatography method. EFFECT: increased yield of the highly purified immunoglobulins, enhanced specificity and activity of immunoglobulins. 1 tbl, 5 ex
The study is being conducted in an IAPT primary care service in North Yorkshire. The study will be recruiting 50 participants experiencing mild to moderate depression who are deemed suitable for 'behavioural activation' low intensity guided self-help intervention. Following telephone screening for intervention, clinicians will ask clients if they wish to hear more about participating in a research study. If participants say yes, their contact details will be passed on to the researcher who will send them the study information sheet and consent form in the post. If the participant consents to taking part in the research, they will be randomised to receive either treatment as usual (low-intensity guided self-help utilising behavioural activation for depression) or treatment with security priming intervention (treatment as usual with an additional security priming task). They will have between 6-8 sessions as routinely delivered within the service and will be asked to complete measures of depression, anxiety and impaired functioning on a sessional basis. The principal investigator at the study site will collect information regarding attendance to therapy, dropout rates, and 'stepping' clients up to higher-intensity therapies as primary outcomes.
Despite disruption of central command of the vasculature during orthostatic maneuvers, individuals with tetraplegia are generally able to be seated in an upright position for long periods of time without developing symptoms of orthostatic intolerance. It must be appreciated however, that orthostatic hypotension may occur unpredictably in persons with chronic tetraplegia. This may result in a range of symptoms due to cerebral hypoperfusion from mild reduction in mental acuity to loss of consciousness. Nitric oxide (NO) is the most potent endogenous vasodilator which is synthesized by the enzyme NO synthase (NOS) and may be largely responsible for orthostatic hypotension in individuals with immobilizing conditions. Recent evidence suggests an up-regulation of inducible nitric oxide synthases (NOS) activity with prolonged exposure to hind limb suspension. The effects of NOS inhibition during orthostasis on blood pressure regulation in those with chronic tetraplegia may provide insight into effective pharmacological therapy to reduce or prevent pathologic orthostatic changes. Treatment with a NOS inhibitor may facilitate the process of mobilization in those with acute higher cord lesions.
The pathophysiological mechanisms of the post-acute sequelae of COVID-19 (PASC) remain unclear. Sex differences not only exist in the disease severity of acute SARS-CoV-2 infection but also in the risk of suffering from PASC. Women have a higher risk of suffering from PASC and a longer time to resolution than men. To explore the possible immune mechanisms of PASC among non-elderly females, we mined single-cell transcriptome data from peripheral blood samples of non-elderly female patients with PASC and acute SARS-CoV-2 infection, together with age- and gender-matched non-PASC and healthy controls available from the Gene Expression Omnibus database. By comparing the differences, we found that a CD14+ monocyte subset characterized by higher expression of signal transducers and activators of transcription 2 (STAT2) (CD14+STAT2high) was notably increased in the PASC patients compared with the non-PASC individuals. The transcriptional factor (TF) activity analysis revealed that STAT2 and IRF9 were the key TFs determining the function of CD14+STAT2high monocytes. STAT2 and IRF9 are TFs exclusively involving type I and III interferon (IFN) signaling pathways, resulting in uncontrolled IFN-I signaling activation and type I interferonopathy. Furthermore, increased expression of common interferon-stimulated genes (ISGs) has also been identified in most monocyte subsets among the non-elderly female PASC patients, including IFI6, IFITM3, IFI44L, IFI44, EPSTI1, ISG15, and MX1. This study reveals a featured CD14+STAT2high monocyte associated with uncontrolled IFN-I signaling activation, which is indicative of a possible type I interferonopathy in the non-elderly female patients with PASC.
Two stimulations sessions per day, with 1 hour apart, for 20 working days, so 4 weeks (frequency of 20 Hz, 100% of motor threshold).Each session lasts 28 min. The duration of the train of 10 s, an inter-train of 80s The total number of pulses is 40000 in 20 trains or 2000 per day.
OBJECTIVES: To analyze the clinical and histopathological characteristics of oral leukoplakia (OL) in the Japanese population and investigate the prevalence and risk factors for epithelial dysplasia (ED) and carcinoma within lesions.
STUDY DESIGN: Data, including age, sex, lesion site, and histopathological features, of 676 cases diagnosed with OL over the previous 10 years were analyzed. Dysplasia and carcinoma prevalence were determined.
RESULTS: In male patients, the most affected site was the gingiva (42.7%), whereas in females, it was the tongue (47.6%). Moreover, ED was more prevalent in males (41.9%), whereas epithelial hyperplasia was more common in females (44.7%). A significant difference was observed between affected sites with regard to the presence of dysplasia. The ED rates by site were 64.6% and 33.7% for the tongue and gingiva, respectively (P < 0.05). The squamous cell carcinoma rates by site were 23.4%, 5.4%, and 3.4% for the tongue, buccal mucosa, and gingiva, respectively (P < 0.05). Logistic regression analysis revealed a higher prevalence of dysplasia in males than it did in females and that the risk for both dysplasia and carcinoma was highest in the tongue.
CONCLUSIONS: Dysplasia is common in OL cases, often showing carcinoma. Early biopsy and interventions are key in OL management.
PURPOSE: To provide the pharmaceutical composition for treating abnormally hypersensitive muscular movement disorder contg. active butulimum toxin and substantially no inactive toxin. CONSTITUTION: This composition consists essentially of freeze-dried active botulinum toxin type A and contains no sodium chloride and has a <25 wt.% inactive toxin content. A preferred example of the composition is a freeze-dried composition which contains in an ampul sealed under vacuum, 100 U of active botulinum toxin type A or a medically-appropriate number of units and about 0.5% of human serum albumin. The freeze-dried botulinum toxin is obtained by dissolving the botulinum toxin into distilled water or a buffer solution contg. a protein stabilizer and no sodium chloride, receiving the resulting solution into a vessel, freezing the solution at <-70 deg.C in the vessel, drying the solution by freeze-drying and removing water from the solution.
Background: Pregnancy loss (PL) is a common, yet rarely examined public health issue associated with an increased risk of impaired mental health, particularly depression.Objective: Previous research shows childlessness to be a correlate of depression after PL. First studies also indicate associations of the type of loss, multiple losses, relationship quality, and coping strategies with depression after the loss of a pregnancy. However, results are inconsistent and the few existing studies show methodological deficits. Therefore, we expect higher depression scores for women without living children, and we exploratively examine the associations between the type of loss, the number of losses, relationship quality, and coping strategies with depression scores for women who suffered a PL.Method: In an online setting, N = 172 women with miscarriage (n = 137) or stillbirth (n = 35) throughout the last 12 months completed the Patient Health Questionnaire (PHQ-D), Brief-COPE, and Partnerschaftsfragebogen (PFB), a German questionnaire measuring relationship quality.Results: In a multiple hierarchical regression analysis, stillbirth, β = 0.15, p = .035, presence of living children, β = -0.17, p = .022, and self-blame/emotional avoidance, β = 0.34, p < .001, are predictors of depression scores. However, there was no association between depression symptoms and other coping strategies, relationship quality, and multiple losses.Conclusions: Especially with regard to women who have no living children, have suffered a stillbirth, or are affected by self-blame/emotional avoidance, health care providers should monitor the presence of depressive symptoms. Our results indicate the need for specific instruments measuring coping style and relationship quality after PL, since the standard items of the PFB and the Brief-COPE seem inappropriate for this setting.
This is a randomized, open label, phase IV study in anemic predialysis patients (Hb between 8 and 11.5 g/dl) who require iron supplementation. The duration of the study for each patient will be approximately 6 months. Patients will be randomized to one of two treatment arms and admitted to the anemia correction phase (days 1-43). Treatment will be intravenous iron sucrose alone versus iron sucrose plus rhEPO. The main treatment evaluation will at the end of the correction phase: The primary end-point will be the change of hemoglobin during correction phase. Secondary end-points will be the change of ferritin and transferrin saturation from baseline to day 43. Safety assessments will include recording of adverse events, vital signs, physical examinations and clinical laboratory tests. Incidence and severity of adverse events will be compared between the two different treatment arms.
PCT No. PCT/EP95/02011 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed May 26, 1995 PCT Pub. No. WO95/33057 PCT Pub. Date Dec. 7, 1995It is described a hybrid molecule of formula GM-CSF-L-EPO or EPO-L-GM-CSF useful for the stimulation of hematopoiesis, comprising GM-CSF and EPO molecules fused together by means of a linker L having a variable length of amino acids, GM-CSF and EPO molecules being either complete molecules or fragments thereof. Such hybrid molecules exhibit a higher specifity of action on erythroid differentiation if compared to that of an equimolar mixture of not-linked GM-CSF and EPO molecules. Further, the present invention describes: DNA sequences encoding such hybrid molecules, which stimolate the hematopoiesis; plasmid vectors containing the genes encoding hybrid molecules and directing their synthesis in host cells; the use of such hybrid molecules for the preparation of a pharmaceutical composition and such pharmaceutical composition useful for stimolation of hematopoiesis.
Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive. Here, we report that SIRPα controls podocyte antigen presentation in specific T cell activation via inhibiting spleen tyrosine kinase (Syk) phosphorylation. First, podocyte SIRPα under lupus nephritis (LN) conditions is strongly downregulated. Second, podocyte-specific deletion of SIRPα exacerbates renal disease progression in lupus-prone mice, as evidenced by an increase in T cell infiltration. Third, SIRPα deletion or knockdown enhances podocyte antigen presentation, which activates specific T cells, via enhancing Syk phosphorylation. Supporting this, Syk inhibitor GS-9973 prevents podocyte antigen presentation, resulting in a decrease of T cell activation and mitigation of renal disease caused by SIRPα knockdown or deletion. Our findings reveal an immunoregulatory role of SIRPα loss in promoting podocyte antigen presentation to activate specific T cell immune responses in LN.