anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Multiple psychosocial factors have been associated with dementia, while the individual or joint effects of various psychosocial states on dementia remain unrevealed due to the complex interplay between those factors. Here, the authors examined the associations of psychosocial factors and patterns with subsequent risk of dementia, and if the associations could be modified by genetic susceptibility to dementia.
METHODS: UK Biobank dementia-free participants were followed from one year after recruitment (median date: 24 January, 2010) until 31 October, 2022. Psychosocial states were measured by 22 items related to five dimensions, including psychiatric history, recent stressful life events, current psychiatric symptoms, social contact, and individual socioeconomic state. We identified clusters of individuals with distinct psychosocial patterns using latent class analysis. Cox proportional hazards models were used to evaluate the association between psychosocial items, as well as psychosocial patterns, and risk of dementia. We further performed stratification analyses by apolipoprotein E (APOE) genotype, polygenic risk score (PRS) of dementia, and family history of dementia.
RESULTS: Of 497,787 included participants, 54.54% were female. During a median follow-up of 12.70 years, we identified 9,858 (1.98%) patients with newly diagnosed dementia. We identified seven clusters with distinct psychosocial patterns. Compared to individuals with a pattern of 'good state', individuals with other unfavorable patterns, featured by varying degrees of poor psychological state ('fair state' and 'mildly, moderately, and extremely poor psychological state'), low social contact or socioeconomic state ('living alone' and 'short education years'), were all at an increased risk of dementia (hazard ratios [HR] between 1.29 and 2.63). The observed associations showed no significant differences across individuals with varying APOE genotypes, levels of PRS, and family histories of dementia.
CONCLUSION: Unfavorable psychosocial patterns are associated with an increased risk of dementia, independent of genetic susceptibility. The findings highlight the importance of surveillance and prevention of cognitive decline among individuals with suboptimal psychosocial state.
Name of medicine: quick-acting Qianliekang medicine (medicine for treating prostatic diseases). Components of the medicine: flos chrysanthemi, herba houttuyniae, radix trichosanthis, radix rehmanniae and rosin. Functions: eliminating dampness, relieving swelling, cooling blood, stopping bleeding, removing pus and promoting regeneration of new tissue, relieving pain, expelling pus and sucking gas, relaxing small and large intestines, eliminating blood arthralgia, promoting blood circulation, regulating pulse condition of five viscera, conditioning intestines and stomach, and benefiting qi and energy. Primary efficacy of the medicine: urethritis, urocystitis, cervicitis, annexitis, proctitis, hemorrhoids, frequent micturition, urgent urination, impotence, premature ejaculation, sexual dysfunction and the like. Usage and dosage: 2-3 times every day, 3g per time, with boiled water before meals. Side effects of the medicine (dizziness, nausea and the like): 1, furuncle, red and swollen pimples in skin of some patients, generally disappearing after 3-4 days; 2, oral mucosal swelling and gum swelling in some patients, generally disappearing after 3-4 days; 3, dozing and sleepy; and 4, accumulation of dry feces, disappearing as stopping application of the medicine. Matters needing attention: not clear. Contraindication: not clear.
The invention relates to a tea polyphenol and ethanol double-disinfection and washing-free hand sanitizer and a preparation method thereof. The tea polyphenol and ethanol double-sterilization no-wash hand sanitizer contains ethanol and a tea extract; the content of the ethanol is 40-75% by mass; the tea extract is tea polyphenol. Furthermore, the tea polyphenol and ethanol double-disinfection and no-wash hand sanitizer also contains glycerol, isopropyl myristate and a thickening agent. The invention also provides a preparation method of the tea polyphenol and ethanol double-disinfection washing-free hand sanitizer. The tea polyphenol and ethanol double-sterilization no-wash hand sanitizer takes ethanol as a main bactericide, and the content of the ethanol in the hand sanitizer can reach 75 percent through a specific preparation method, so that coronavirus can be effectively killed. The prepared wash-free hand sanitizer overcomes the problems of foaming and opaqueness of the traditional product, retains the natural color of tea polyphenol, is glittering and translucent faint yellow-yellowish red as a whole according to the concentration condition, and is more natural, beautiful and beautiful.
Back pain is one of the major global challenges and is one of the most prevalent musculoskeletal disorders occurring in 80% of people at least once in their lifetime. Therefore, the need to find appropriate treatment methods for this issue is very important. The objective is to examine the short-term and acute effects of a treatment session with dry needling, massage therapy, stretching exercises and Kinesio tape on pain, functional disability, position sense and range of motion in elite bodybuilders with non-specific chronic low back pain. The sample of this quasi-experimental study consisted of 48 bodybuilders with non-specific chronic low back pain (all male, mean age = 25.96 ± 2.18 years; mean weight = 74.45 ± 4.51 kg; mean height = 173.88 ± 3.74 cm; mean BMI = 24.60 ± 0.74 kg/m2) who randomly were placed in 4 dry needling, massage therapy, stretching exercises and Kinesio tape groups. The duration of each intervention was 30 min. The dependent variables in this study included the massage range of motion, position sense tests and visual pain scale that were taken separately from each subject in pretest, posttest (acute effect) and follow-up test (72 h after posttest; short-term effect). The results of a 4 (groups) × 3 (time) the mixed ANOVAs showed that pain in the short-term phase was significantly lower in the dry needling group than in the stretching and massage groups (P < 0.05). Also in the acute effect phase, the flexion range of motion was significantly lower in the dry needling group than in the massage group (P < 0.05). Furthermore, the two groups of stretching and massage exercises showed significantly greater range of motion (P < 0.05). Other comparisons were not significant (P > 0.05). The findings of the study showed that both massage and stretching treatment have higher acute effects, while dry needling treatment was more effective in follow up. On the other hand, these findings show that these treatment methods can have immediate and lasting positive effects in improving the performance in elite bodybuilders with non-specific chronic low back pain.
The capacity to oxidize (burn) fat as fuel for exercise may have important implications for health and performance. For example, increased fat oxidation could help to induce a negative fat balance and over time improve body composition. Furthermore, increasing the oxidation of fat could spare carbohydrate utilization during exercise which should improve endurance performance by preserving the bodies limited carbohydrate reserves for the latter stages of competition. Interestingly, there is substantial individual variation in the balance of fuels used for energy during exercise and in particular the maximal capacity to oxidize fat (MFO). Whilst habitual diet is known to affect the metabolic response to exercise, the influence of nutrition on the individual variability observed in maximal fat oxidation has not been comprehensively studied.

Therefore, the proposed investigation aims to build on current understanding of how various nutritional factors influence MFO during exercise. Based on previous small intervention studies, it is suspected that energy balance and macronutrient content or distribution may exert the strongest influence on MFO during exercise. Specifically, the main hypothesis would be that negative energy balance; higher fat intake and/or low carbohydrate intake would be the strongest positive influencer's of MFO. Nonetheless, the determination of an array of habitual and acute nutrient intake data in a relatively large cohort of healthy individuals will enable an insight into the influence of a comprehensive array of nutrients on MFO during exercise. With a greater understanding of the nutritional factors that influence MFO during exercise, new nutritional interventions can be designed to promote the oxidation of fat for improved health and performance.
PROBLEM TO BE SOLVED: To obtain a composition containing the subject compound, useful for treating cyanide poisoning, excellent in stability and preservable for a long period. SOLUTION: Hydroxocobalamin is first lyophilized in an acidic medium; thereafter, the lyophilized product is dissolved again in a neutral saline solution (pref. an aqueous solution of sodium chloride, esp. physiological saline solution). To obtain the lyophilized product, a hydroxocobalamin solution is prepared in an acidic medium which may be incorporated with a filler (pref. at pH3.5-5.5) and then lyophilized in a vessel intended to use.
NSAIDs, including diclofenac, can cause serious skin adverse reactions such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. NSAIDs can also cause fixed drug eruption (FDE). FDE may present as a more severe variant known as generalized bullous fixed drug eruption (GBFDE), which can be life-threatening. These serious events may occur without warning. Inform patients about the signs and symptoms of serious skin reactions, and to discontinue the use of diclofenac sodium delayed-release tablets at the first appearance of skin reaction or any other sign of hypersensitivity. Diclofenac sodium delayed-release tablets are contraindicated in patients with previous serious skin reactions to NSAIDs (see CONTRAINDICATIONS).
The invention discloses a traditional Chinese medicine fumigating and washing agent for treating knee osteoarthritis. Knee osteoarthritis belongs to the scope of bone impediment in the aspect of traditional Chinese medicine, and according to the the etiology and the pathogenesis of knee osteoarthritis, knee osteoarthritis is mainly caused by the deficiency of the liver and the kidneys and qi stagnation and blood stasis and vein impatency caused byexogenous pathogenic factors such as exogenous wind cold dampness. Thus, traditional Chinese medicine of artemisia japonica, erythrina arborescens small, mentha rotundifolia(L.) huds, Viola philippica Cav. Subsp. Malesi-ca W. Beck., radix ampelopsis, herba violae acuminatae, cactus, stephania sinica diels, abrus herbs, verbena officinalis, sida szechuensis matsuda, tamariskoid spikemoss herbs, herbs of Japanese farfugium, crassocephalum crepidioides and Jiachala is selected and prepared into the traditional Chinese medicine fumigating and washing agent, as clinically proved, the total effective rate reaches 97.5%, and the traditional Chinese medicine fumigating and washing agent has no side effects.
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.
Polyglycolic acid sheets and fibrin glue are routinely used in surgical procedures. Their usefulness in gastrointestinal endoscopy is mainly to prevent complications (bleeding, delayed perforation, stenosis, etc.) associated with procedures such as endoscopic submucosal dissection and endoscopic mucosal resection, with most reports on iatrogenic and secondary conditions. However, there are few reports on primary gastrointestinal diseases. Herein, we report three cases of gastrointestinal bleeding that were successfully treated with endoscopic hemostasis by sealing the lesions with polyglycolic acid sheets and fibrin glue. Case 1 was of an 83-year-old woman with a rare duodenal perforation that was treated with omental plugging who experienced subsequent bleeding from the greater omentum. Case 2 was of a 73-year-old woman with an acute hemorrhagic rectal ulcer that was difficult to treat even after performing standard endoscopic hemostasis techniques; however, surgery was avoided by sealing. Case 3 was that of an 89-year-old woman with a stercoral ulcer, treated curatively using a combination of sealing and argon plasma coagulation right from presentation based on the lessons learned from Cases 1 and 2. Endoscopic hemostasis using a polyglycolic acid sheet and fibrin glue may be a new treatment option for gastrointestinal bleeding particularly in refractory or rare causes.
Provided are a Lactobacillus brevis strain and anti-cervical cancer use thereof. The provided Lactobacillus brevis is specifically (Lactobacillus brevis) YNH, which is deposited under CGMCC No. 24368 at the China General Microbiological Culture Collection Center. Experiments have demonstrated that Lactobacillus brevis YNH has the effects of reducing the proliferation activity of Hela cells of cervical cancer, arresting the Hela cell cycle at the S phase, reducing the mitochondrial membrane potential of Hela cells and promoting the apoptosis of Hela cells. Lactobacillus brevis YNH can inhibit the PI3K/AKT signaling pathway to inhibit the proliferation of Hela cells, promote apoptosis, and inhibit the proliferation of subcutaneous tumors of cervical cancer in nude mice, has relatively good inhibitory activity against Hela cells of cervical cancer, and can be used for adjusting the microecological balance of the genital tract of cervical cancer patients, preventing and treating cervical cancer, and improving the survival rate of cervical cancer patients. The strain is used for preparing fermented food and related drugs for inhibiting the development and progression of cervical cancer, thus having very wide application prospects.
Novel dental polymeric compositions useful as an adhesive dental restoration material are based on a polymer obtained by the reaction of methacryloxyethyl trimellitic acid anhydride and methyl methacrylate monomer, in the presence of a free radical catalyst. They contain at least one compound selected from silver, nickel, tin, silicon, copper and titanium or their oxides. The preferred amount of these compounds is in the range of between 2% to 20% by volume of the polymer. The compounds should be finely ground, possessing a particle size in the range of between 5 to 50 microns. Optionally, the compositions will contain a material capable to release anions, most preferred being fluoride-based material, in an amount of between 1% to 10% by weight of the composition. The compositions impart bonding to fresh or old amalgam, as well as to dentin, enamel, porcelain and various alloys.
Reiki Master will perform the teaching and attunement process for Level 1 Reiki and teach the caregiver(s) how to complete a simple 10-minute Reiki session with the patient and a 10-minute self-Reiki session for the caregiver(s). The Reiki Master will explain that Reiki sessions can be given whenever the patient and caregiver feel it is appropriate, but sessions should be at minimum twice per 24-hour period for at least 10 minutes with at least two hours between sessions. Reiki sessions may be more frequent than twice per day and/or longer than 10 minutes. Self-Reiki sessions should be performed daily for at least 10 minutes but maybe more frequent and/or longer in length. Each family caregiver will receive a copy of the book. The patient and caregiver will wear a Holter monitor continuously for 48 hours beginning when the caregiver(s) are trained in Reiki to measure HRV, a valid measure for stress.
FIELD: cosmetology. SUBSTANCE: innovation deals with developing cosmetic preparations normalizing physiological state of skin surfaces. Said cosmetic preparation includes cosmetically acceptable organic liquid with predominantly dissolved carbon dioxide. The preparation provides the impact of stable internal carbon dioxide- enriched gaseous phase upon skin tissues. EFFECT: additional useful properties of cosmetic preparations. 3 cl
This study aimed to reduce alexithymia levels in nursing students with emotion regulation training based on a cognitive behavioral approach. The study was conducted with 74 nursing students, 37 in the intervention group and 37 in the control group, studying at a foundation university in the 2023-2024 academic year. The study data were collected using the data collection form and the Toronto Alexithymia Scale-20 (TAS-20). Data collection tools were applied three times as pre-post and follow-up tests. Male and female students who met the inclusion criteria of the study were determined by using the pre-test of the population. For the sample group to represent the population, students with high levels of alexithymia were identified by stratification by determining the class and gender ratios. Then, students were assigned to intervention and control groups by randomization. The 7-session training program prepared for the students in the intervention group was applied. No intervention was made to the control group during the implementation. After the training sessions were completed, post-test data were collected. Follow-up measurements were made three months later.
Heart failure (HF) is the fastest-growing disease with a higher fatality rate. The most differentiating feature of HF is pulmonary or peripheral edema, which is characterized by a gradient between intravascular and extravascular pressure. Loop diuretics were chosen as the primary treatment for edema associated with HF due to their efficacy and early onset of action. If an oral dose had not been provided, intravenous (IV) administration of torsemide, or equal doses of furosemide and bumetanide, was preferred. However, the key variables for selecting and administering loop diuretics are their pharmacological qualities as well as their clinical efficacy. Torsemide has greater bioavailability, a higher rate of absorption, a longer duration of action, and lesser ototoxicity, making it the primary choice in the management of edematous HF.
Barrett's oesophagus is the only known precursor to oesophageal adenocarcinoma, a cancer with very poor prognosis. The main risk factors for Barrett's oesophagus are a history of gastro-oesophageal acid reflux symptoms and obesity. Men, smokers and those with a family history are also at increased risk. Progression from Barrett's oesophagus to cancer occurs via an intermediate stage, known as dysplasia. However, dysplasia and early cancer usually develop without any clinical signs, often in individuals whose symptoms are well controlled by acid suppressant medications; therefore, endoscopic surveillance is recommended to allow for early diagnosis and timely clinical intervention. Individuals with Barrett's oesophagus need to be fully informed about the implications of this diagnosis and the benefits and risks of monitoring strategies. Pharmacological treatments are recommended for control of symptoms, but not for chemoprevention. Dysplasia and stage 1 oesophageal adenocarcinoma have excellent prognoses, since they can be cured with endoscopic or surgical therapies. Endoscopic resection is the most accurate staging technique for early Barrett's-related oesophageal adenocarcinoma. Endoscopic ablation is effective and indicated to eradicate Barrett's oesophagus in patients with dysplasia. Future research should focus on improved accuracy for dysplasia detection via new technologies and providing more robust evidence to support pathways for follow-up and treatment.
BACKGROUND: Severe infections caused by carbapenem-resistant Acinetobacter baumannii (CRAB) have been reported increasingly over the past few years. Many in-vivo and in-vitro studies have suggested a possible role of intravenous fosfomycin for the treatment of CRAB infections.
METHODS: This multi-centre, retrospective study included patients treated with intravenous fosfomycin for severe infections caused by CRAB admitted consecutively to four hospitals in Italy from December 2017 to December 2022. The primary goal of the study was to evaluate the risk factors associated with 30-day mortality in the study population. A propensity score matched analysis was added to the model.
RESULTS: One hundred and two patients with severe infections caused by CRAB treated with an intravenous fosfomycin-containing regimen were enrolled in this study. Ventilator-associated pneumonia (VAP) was diagnosed in 59% of patients, primary bacteraemia in 22% of patients, and central-venous-catheter-related infection in 16% of patients. All patients were treated with a regimen containing intravenous fosfomycin, mainly in combination with cefiderocol (n=54), colistin (n=48) or ampicillin/sulbactam (n=18). Forty-eight (47%) patients died within 30 days. Fifty-eight (57%) patients experienced clinical therapeutic failure. Cox regression analysis showed that diabetes, primary bacteraemia and a colistin-containing regimen were independently associated with 30-day mortality, whereas adequate source control of infection, early 24-h active in-vitro therapy, and a cefiderocol-containing regimen were associated with survival. A colistin-based regimen, A. baumannii colonization and primary bacteraemia were independently associated with clinical failure. Conversely, adequate source control of infection, a cefiderocol-containing regimen, and early 24-h active in-vitro therapy were associated with clinical success.
CONCLUSIONS: Different antibiotic regimens containing fosfomycin in combination can be used for treatment of severe infections caused by CRAB.
The young individuals in the control group will be informed about the study, including its purpose and methodology, and their consent will be obtained. The control group will receive sleep education, consisting of two educational presentations provided 15 days apart. The questionnaires of the scales used for analysis will be administered to assess their sleep problems. The content of the education will be prepared based on the literature and will be reviewed by at least three experts.