anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Childbirth is commonly regarded as one of life's most painful experiences and, like childbirth, the postpartum period can also be painful for women. Pain in the immediate postpartum period may significantly affect a woman's overall delivery experience. Pain control is especially important in this period, as women are bonding with their infant and trying to initiate breastfeeding, which may be adversely affected by poor pain management.

Postpartum pain may come from multiple sources. Women experience uterine cramping as a result of uterine involution. Depending on delivery type, women may also have incision pain following cesarean section or perineal pain resulting from episiotomy, perineal tears, or generalized genital trauma during delivery. Perineal pain is common, present in 75% of patients with intact perineum and up to 95-97% with perineal lacerations or episiotomies during the first day after delivery. Commonly employed methods of controlling postpartum pain include opioid analgesics, non-steroidal anti-inflammatories, acetaminophen, and topical analgesics. Pain medication is generally administered via oral or intravenous route. Several studies have investigated suppositories as an alternative method of improving pain following delivery. A double-blinded randomized controlled trial by Wilasrusmee et al (2008) showed naproxen suppositories to be effective for reducing perineal pain after vaginal delivery. Another study showed prophylactic rectal diclofenac to provide effective analgesia after perineal repair, maintained into second and third day postpartum, and a Cochrane Review showed NSAID suppositories to be associated with less pain 24 hours after birth.

Rectal analgesia provides a means of improving pain control through local effects on the perineum and uterus while possibly decreasing systemic absorption, which may in turn decrease systemic side effects and transmission to the newborn infant through breast milk. B\&O suppositories contain two medications that could potentially decrease postpartum pain. Morphine, the principle agent in opium, binds opioid receptors and blocks ascending pain pathways. Atropine, a major active component of belladonna, blocks acetylcholine receptors, leading to smooth muscle relaxation. This quality may significantly improve pain from uterine contractions during the postpartum period. The primary aim of our study is to investigate whether belladonna and opium suppositories decrease patient-reported pain in the immediate postpartum period.
In day 1 each child in this treatment arm will receive a 100 mg tablet of mebendazole plus one 500 mg placebo tablet in the morning. In the afternoon of day 1 they will only receive the 100 mg tablet of mebendazole. In day 2 and 3 each child will receive one 100 mg tablet of mebendazole twice a day (in the morning and in the evening).
PURPOSE: The automatic segmentation and detection of prostate cancer (PC) lesions throughout the body are extremely challenging due to the lesions' complexity and variability in appearance, shape, and location. In this study, we investigated the performance of a three-dimensional (3D) convolutional neural network (CNN) to automatically characterize metastatic lesions throughout the body in a dataset of PC patients with recurrence after radical prostatectomy.
METHODS: We retrospectively collected [68 Ga]Ga-PSMA-11 PET/CT images from 116 patients with metastatic PC at two centers: center 1 provided the data for fivefold cross validation (n = 78) and internal testing (n = 19), and center 2 provided the data for external testing (n = 19). PET and CT data were jointly input into a 3D U-Net to achieve whole-body segmentation and detection of PC lesions. The performance in both the segmentation and the detection of lesions throughout the body was evaluated using established metrics, including the Dice similarity coefficient (DSC) for segmentation and the recall, precision, and F1-score for detection. The correlation and consistency between tumor burdens (PSMA-TV and TL-PSMA) calculated from automatic segmentation and artificial ground truth were assessed by linear regression and Bland‒Altman plots.
RESULTS: On the internal test set, the DSC, precision, recall, and F1-score values were 0.631, 0.961, 0.721, and 0.824, respectively. On the external test set, the corresponding values were 0.596, 0.888, 0.792, and 0.837, respectively. Our approach outperformed previous studies in segmenting and detecting metastatic lesions throughout the body. Tumor burden indicators derived from deep learning and ground truth showed strong correlation (R2 ≥ 0.991, all P < 0.05) and consistency.
CONCLUSION: Our 3D CNN accurately characterizes whole-body tumors in relapsed PC patients; its results are highly consistent with those of manual contouring. This automatic method is expected to improve work efficiency and to aid in the assessment of tumor burden.
Anterior cruciate ligament (ACL) injury is a common orthopedic disease with a high incidence, long recovery time, and often requiring surgical treatment. However, the susceptibility factors for ACL injury are currently unclear, and there is a lack of analysis on the differences in the ligament itself. Previous studies have focused on germline mutations, with less research on somatic mutations. To determine the role of somatic mutations in ACL injuries, we recruited seven patients between the ages of 20 and 39 years diagnosed with ACL injuries, collected their peripheral blood, injured ligament ends, and healthy ligament ends tissues, and performed exome sequencing with gene function enrichment analysis. We detected multiple gene mutations and gene deletions, which were only present in some of the samples. Unfortunately, it was not possible to determine whether these somatic mutations are related to ligament structure or function, or are involved in ACL injury. However, this study provides valuable clues for future in-depth research.
The invention relates to a traditional Chinese medicine composition used for treating cholecystitis. The traditional Chinese medicine composition comprises following raw materials, by weight, 20 to 30 parts of artemisia capillaries, 20 to 30 parts of lysimachia christinae hance, 20 to 30 parts of dandelion, and 10 to 15 parts of radix curcumae. The traditional Chinese medicine composition can be made into capsules, particulate agents, tablets, mixtures or syrups. Curative effect of the traditional Chinese medicine composition on cholecystitis is obvious, and cure rate is high. In addition, the traditional Chinese medicine composition only comprises four kinds of traditional Chinese medicine raw materials, so that the traditional Chinese medicine composition is more convenient for preparation, and labour and time are saved. It is confirmed by safety analysis results that toxic and side effects of the traditional Chinese medicine composition are few, so that the traditional Chinese medicine composition is easily accepted by patients.
PURPOSE: To efficiently produce a superior tasting pharmaceutical composition by compacting a mixture of a base and an acid, milling the obtained compact to make a foaming mixture, adding a pharmaceutically active agent and a granulating agent to the mixture, allowing them to foam and milling the resultant porous particles followed by formulation. CONSTITUTION: The objective pharmaceutical component is obtained as follows. Stoichiometric amounts of an appropriate base and an appropriate acid are mixed in a press and compressed to form a compact. The obtained compact is then milled to form an evenly distributed foaming mixture of the base and the acid. The mixture is added to a preparation of a pharmaceutically active agent to form an active mixture. Subsequently, the active mixture is further mixed with an appropriate amount of a granulating agent and the resultant mater is granulated, wherein the granulating agent, which is in combination with the active mixture, form water- containing wet granules. The wet granules are dried by heating, and whereby the applied heat and the water in the wet granules cause the acid and the base to react with each other and to release gas from the wet granules.  Thus, porous particles are produced. The porous granules are then milled to form powder. The powder is compressed to form tablets, used in a reconstitutable powder dosage form, or filled in a capsule.
This prospective cohort study of patients obtaining medical abortion medications by mail. The study investigators aim to recruit approximately 120 patients for this study across three study sites that have extensive experience providing early medical abortion. Five days after undergoing in-person consultation and necessary exams to assess eligibility for medical abortion, study team will mail study participants medical abortion pills and two multi-level urine pregnancy tests. Medical abortion follow-up will occur at the participant's home approximately two weeks after the initial visit, and the multi-level pregnancy test will be used to assess abortion outcome. At follow-up, study participants will be asked questions about the results of the multi-level pregnancy test, and their experience and feedback about the acceptability of the process. At the conclusion of the study, investigators will interview providers to better undertand their experience with the simplified medical abortion service delivery model.
The upper and lower limits of autoregulation determined by ICM+ software are used to guide the range of blood pressure control, but no more than 40% above or below the usual BP. From when the upper or lower limit of autoregulation appeared in ICM+ software to 48h after revascularization, the total time of actual BP beyond the CA range will be no more than two hours through drug intervention.
PURPOSE:To provide an excellent skin cosmetic containing a specific ascorbic acid derivative, storable stably for a long period without causing the discoloration, the change in the smell, the lowering of activity, etc., free from skin irritation, beautifying the body while giving an agreeable feeling and capable of keeping healthy skin. CONSTITUTION:The objective cosmetic contains a 6-O-higher acyl ascorbic acid-2-sulfuric acid ester salt (preferably e.g. 6-O-dodecanoylascorbic acid-2- sulfuric acid ester disodium salt, etc.) having moderate hydrophilic property and lipophilic property, and excellent stability in the cosmetic system, compatibility with the cosmetic base, emulsifiability and safety to the human body. The compound is added to the cosmetic base singly or as a mixture of two or more compounds. The amount of the compound is 0.05-20wt% based on the whole cosmetic composition. EFFECT:The design of the skin cosmetic preparation can be facilitated. The cosmetic compounded with the agent has high stability with time and exhibits effect to prevent the aging of the skin as well as the skin beautifying effect.
People will receive an education session per month for a period of six months with an average duration of 30 minutes. These will be performed by nurses outside the collection of phase base line and follow-up measurements, previously trained for the purpose.
Patients will initially receive 6 vaccinations over 12 weeks and 7 infusions of nivolumab every two weeks over 14 weeks. Toxicity assessments will be performed with each dose of vaccine, and 3 weeks after the completion of therapy at week 15. Patients who do not have disease progression at the week 15 evaluation are permitted to receive 4 additional vaccines administered approximately every 8 weeks. This maintenance vaccine course would begin at week 19.This cohort has completed recruitment.
PURPOSE:A safe, inexpensive remedy for pimples of optical use and pharmaceutical preparation for remedying pimples, having the same effects as that of existing remedy by ODT therapy, comprising ethanol as a main component. CONSTITUTION:A remedy for pimples of external use, comprising ethanol as a main component, and, if necessary, purified water and a humectant (e.g., glycerin, etc.). The remedy is impregnated into a carrier to give a pharmaceutical preparation for remedying pimples. It has been found that ODT therapy of aqueous solution of ethanol is extremely effective for pimples regardless of the concentration, and as the same effects as that of internal use of existing antibiotic. Antimicrobial action on causative agent of acne of alcohol may be cited as its action mechanism. The remedy has more fat solubility than sulfur camphor lotion, is more easily permeated into folliculus pili, and shows antimicrobial action. It suppresses sebum retention in folliculus pili, and inhibits comedo and steatorrhea. It has further a refreshing feeling, and is a useful remedy for pimples.
In October 2023, Nigeria integrated the single-dose human papillomavirus (HPV) vaccine into its routine immunization program, aiming to protect 7.7 million girls aged 9 to 14 years. This milestone in the fight against HPV-related cancers, especially cervical cancer, faces significant challenges due to high vaccine rejection rates driven by misinformation and cultural barriers. Despite the vaccine's proven safety and efficacy, uptake remains low. This communication highlights the urgent need for a comprehensive public health education campaign to address these barriers. Proposed strategies include leveraging digital health technologies, integrating HPV education into school curricula, training community health workers, engaging religious and cultural leaders, and launching media campaigns featuring personal narratives. Implementing these evidence-based interventions is crucial for dispelling myths, misconceptions, and skepticism surrounding HPV vaccines. This will enhance acceptance and uptake, ultimately reducing cervical cancer mortality in Nigeria.
Participants in PRO group receive dietary supplementation with protein-rich supplements immediately before and after each exercise training session. The interventions include 30 training sessions.
In recent years, artificial intelligence has made remarkable strides, improving various aspects of our daily lives. One notable application is in intelligent chatbots that use deep learning models. These systems have shown tremendous promise in the medical sector, enhancing healthcare quality, treatment efficiency, and cost-effectiveness. However, their role in aiding disease diagnosis, particularly chronic conditions, remains underexplored. Addressing this issue, this study employs large language models from the GPT series, in conjunction with deep learning techniques, to design and develop a diagnostic system targeted at chronic diseases. Specifically, performed transfer learning and fine-tuning on the GPT-2 model, enabling it to assist in accurately diagnosing 24 common chronic diseases. To provide a user-friendly interface and seamless interactive experience, we further developed a dialog-based interface, naming it Chat Ella. This system can make precise predictions for chronic diseases based on the symptoms described by users. Experimental results indicate that our model achieved an accuracy rate of 97.50% on the validation set, and an area under the curve (AUC) value reaching 99.91%. Moreover, conducted user satisfaction tests, which revealed that 68.7% of participants approved of Chat Ella, while 45.3% of participants found the system made daily medical consultations more convenient. It can rapidly and accurately assess a patient's condition based on the symptoms described and provide timely feedback, making it of significant value in the design of medical auxiliary products for household use.
INTRODUCTION: Lower gastrointestinal bleeding (LGIB) is a common cause of emergency hospitalization and may require readmission for re-bleeding. A novel adhesive endoscopic hemostatic powder (UI-EWD/NexpowderTM, Nextbiomedical, Incheon, South Korea) has been developed and recently utilized for LGIB hemostasis. The aim of the current study was to assess the efficacy and safety of UI-EWD as a rescue therapy for the treatment of refractory LGIB.
METHODS: In this study, a total of 59 consecutive patients with LGIB who experienced initial hemostasis failure with conventional endoscopic therapy were enrolled into this multicenter single-arm study. These patients subsequently underwent UI-EWD application for the refractory LGIB hemostasis. We evaluated the success rate of hemostasis, re-bleeding rate within 30 d, and adverse events related to UI-EWD.
RESULTS: UI-EWD was successfully administered to the bleeding sites in all enrolled refractory bleeding patients. Hemostasis was achieved in the entirety of the 59 patients (100%). The cumulative re-bleeding rate within 30 d was 8.5% (5/59). There were no UI-EWD-related adverse events, such as perforation nor embolism.
CONCLUSION: Based on our results, the utilization of UI-EWD demonstrated a remarkable success rate in achieving hemostasis for refractory LGIB, while also exhibiting promising outcomes in reducing the re-bleeding rate within a 30-day period. Particularly, UI-EWD exhibits a favorable safety profile across all segments of the colon in cases of refractory LGIB.
This study aimed to determine knowledge, attitude, and practices towards Noise-Induced Hearing Loss among maintenance and administration workers in selected health facilities in the Modimolle-Mookgopong Municipality. Non-probability convenient sampling was used to select 250 participants. Maintenance workers were populated within the age range of 26-35 years, being more than administrative personnel (COR 1.59, CI 0.8-3.16). Maintenance workers showed more knowledge of noise being an unwanted sound (COR 1.04, CI 0.29-3.73), an ear infection (COR 4.65, CI 1.48-14.58) and poor hearing of speech as a sign of hearing loss (AOR 0.25, CI 0.07-0.86). Thirty-four percent (34%) of maintenance workers believed that ear screening and assessments are important while 17.9% believed not to be important. Forty-eight percent (58%) of maintenance workers suggested that they could not use hearing protectors effectively without training while 13.7% suggested training is needed.
All participants with myocarditis are selected among the participants who received at least 1 dose of Moderna vaccination targeting SARS-CoV-2. Cases are those participants who develop myocarditis or pericarditis any time during the follow-up after Moderna vaccination targeting SARS-CoV-2 vaccination.
The present invention relates to a composition comprised of AKAP12 (A-Kinase anchoring protein 12) and to uses of AKAP12 mutant zebrafish as an animal model. More particularly, the following characteristics are noted in the present AKAP12 mRNA knockdown zebrafish: crooked or shortened tail, inability to move normally, non-uniform micro-vasculature in the brain, and change in heart shape with non-uniform and weak heartbeats. It also has various circulatory and genetic defects, such as hemorrhage from the ventricles of the heart, brain, and retina. All of these defects can be cured with AKAP12 injection. Therefore, AKAP12 can be used as an active component for a composition to prevent and heal circulatory and genetic defects that are caused by AKAP12 deficiency, and as a hemorrhage inhibitor. Further, the AKAP12 deficient mutant zebrafish can be useful as an animal model for verification of effectiveness of treatment for genetic defects in the circulatory system.
PURPOSE:To provide the titled vaccine obtained by mixing virus liquid obtained by culturing attenuated Japanese encephalitis virus in culture cell, with virus liquid obtained by culturing attenuated swine parvovirus in culture cell. CONSTITUTION:A mixed live vaccine for Japanese encephalitis and swine parvovirus infection can be prepared by mixing (A) a virus liquid prepared by inoculating an attenuated Japanese encephalitis virus in a culture cell suitable for the proliferation of attenuated Japanese encephalitis virus (e.g. culture cell originated from swine kidney, culture cell originated from hamster kidney or lung, etc.) with (B) a virus liquid prepared by inoculating an attenuated swine parvovirus in a culture cell sutable for the proliferation of attenuated swine parvovirus (e.g. culture cell originated from swine kidney, culture cell originated from swine thyroidea, etc.) at a ratio of 1:(1-4). EFFECT:Various kinds of labor and economic load can be reduced remarkably. Since the vaccine is safe, the productivity of pig can be improved.
BACKGROUND: Australian Indigenous (AI) populations face significant socioeconomic disadvantage and have poorer health outcomes when compared to their non-AI counterparts. There is a paucity of published literature on outcomes following hip fracture in the AI population.
METHODS: We performed a retrospective cohort study comparing outcomes following hip fracture in AI and non- AI patients presenting to a single regional trauma centre. The primary outcome of interest was all-cause mortality. Secondary outcomes of interest were the odds of postoperative delirium and length of stay in hospital. All outcomes were adjusted against collected baseline covariates.
RESULTS: One hundred and twenty-seven hip fractures were identified across 125 patients. There were 62 hip fractures in the AI group and 65 in the non-AI group. The adjusted hazard ratio (HR) for all-cause mortality was not statistically significant when comparing Indigenous versus non-Indigenous patients (HR = 2.37, P = 0.055). Adjusted odds of postoperative delirium was lower in Indigenous patients (OR = 0.12; P = 0.018). The AI cohort had a 4 day longer median length of stay, which was not statistically significant when adjusted for covariates.
CONCLUSION: AI patients with hip fractures were younger, had a higher Charlson Comorbidity Index Score and American Society of Anaesthesiologists grade, as well as a higher incidence of diabetes and associated end-organ sequalae. There was no difference in all-cause mortality. Odds of postoperative delirium was lower in the AI group. We did not find any difference in the length of hospital stay.
In education group, each subject in the experimental group was taught individually according to investigator's brochure in the outpatient department by researchers. Three months later, participants in the education group received a follow-up phone call in order to clarify any questions related to the brochure. All participants completed posttest at 6-month follow-up.