anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To investigate the relationship of serum uric acid (Uacid) and derived parameters as predictors of insulin resistance (IR) and elevated liver transaminases in children and adolescents METHODS: Data of 1648 participants aged 10-18 years was analyzed using nationwide survey. Logistic regression analysis was performed with IR and elevated liver transaminases as dependent variables, and odds ratios (ORs) and 95% confidence intervals (CIs) for tertiles 2 and 3 of each parameter in comparison to tertile 1, which served as the reference. Receiver operating characteristic (ROC) curves were generated to assess predictability of the parameters for IR and elevated liver transaminases.
RESULTS: Hyperuricemia, IR, and elevated liver transaminases were significantly associated with each other. All Uacid and derived markers showed continuous increase in ORs and 95% CIs for IR and elevated liver transaminases across the tertiles of several biochemical and metabolic variables of interest (all p < 0.001), and were also significantly predictive in ROC curve. Overall, Uacid combined with obesity indices showed higher ORs and area under the curve (AUC) compared to Uacid alone. Uacid-body mass index (BMI) standard deviation score presented the largest AUC for IR. For elevated liver transaminases, Uacid-BMI and Uacid-waist-to-height ratio showed the largest AUC.
CONCLUSIONS: Uacid combined with obesity indices are robust markers for prediction of IR and elevated liver transaminases in children and adolescents. Uacid and derived markers have potential as simple markers which do not require fasting for screening of IR and elevated liver transaminases in children and adolescents.
From 166 first time mother-infant recruited, 128 completed the trail. Intervention group, mother-infant dyads got a month long weekly based training in small workshop groups about nutrition, feeding and parenting when infants were 4-6 months old. training was given by a highly experience pediatric dietitian and social worker. Thereafter, internet-based support continued until infants reached 12 months. The control group received customary support via municipal mother-child health clinics. Mealtime interactions were videotaped at home setting at 12 months and were evaluated using the Chatoor feeding scale by blinded (to group) viewers.
PURPOSE:To obtain in large quantities at low cost aromoline having various physiological activities such as vasodilative activity and antiallergic activity by separating and collecting aromoline from the enlarged or lumpy roots of Sinomenium diversifolium. CONSTITUTION:The enlarged or lumpy roots of Sinomenium diversifolium are e.g. dried and ground and then extracted with an organic solvent (pref. a lower alcohol, esp. methanol). The solvent is then distilled off, and the residue is extracted with an acidic aqueous solution of pH <= 3 (esp. aqueous citric acid solution) and an alkali (esp. ammonia) is then added to said aqueous solution to adjust the pH value to 9 - 10 followed by extraction with an organic solvent (esp. chloroform) again. If needed, the extract is further purified by e.g. chromatography to separate and collect aromoline from said roots, thus obtaining the objective aromoline in large quantities at low cost simultaneously from the above same tissue which has been cultivated for the purpose of extracting cepharanthine and isotetrandrine etc.
PROBLEM TO BE SOLVED: To obtain an oral composition excellent in germicidal activities, and good in palatability by formulating a prescribed amount of a specific germicidal enhancer with a system comprising a quarternary ammonium salt-based germicidal agent and/or a nonionic germicidal agent. SOLUTION: This oral composition is obtained by formulating a germicidal agent containing at least one or more kinds selected from a quarternary ammonium salt-based germicidal agent and/or a nonionic germicidal agent with >=0.005 wt.% cineole based on the whole amount of the composition and a nonionic surfactant. The formulating amount of the germicidal agent is 0.001-0.5 wt.% based on the whole amount of the composition. The nonionic surfactant is exemplified by a fatty acid ester of polyoxyethylenesorbitan having 5-20 mol. average polymerization degree of ethylene oxide, and 12-18 alkyl chain length of the fatty acid, and preferably formulated so as to be 0.01-5 wt.% in the whole amount of the composition. The cineole is exemplified by mint, citrus and grape, and preferably formulated so as to be 0.005-1.0 wt.%.
The invention provides a traditional Chinese medicine composition having anticancer effects and a preparing method and uses thereof. The traditional Chinese medicine composition mainly comprises following raw material medicines: rheum officinale and gadfly. The preparing method includes: weighing the raw material medicines according to a ratio, and extracting with water or an organic solvent mutually soluble with water; or weighing the raw material medicines according to the ratio and preparing by adoption of a water extraction and alcohol precipitation method, wherein the alcohol precipitation concentration is 50-90%. The uses of the composition relate to applications of the composition in preparation of medicines treating cancer especially medicines treating cervical cancer. The composition comprises the rheum officinale and the gadfly in a weight ratio of 1:0.2-4. By compatibility of the rheum officinale and the gadfly, the composition has coordinate repression effects for Hela cells and has good anticancer effects.
Participants will receive their standard treatment for 15 months but no treatment for anemia correction unless Hb level will be less than (\<) 10.5 g/dL on 2 consecutive visits of 2 weeks interval or the Hb level will be \<10 g/dL on a single determination. In such cases participants could receive epoetin beta at a starting dose of 2000 IU SC once weekly to reach and maintain a target Hb level of 10.5 to 11.5 g/dL. Standard treatment will be as per investigator discretion.
The invention discloses attapulgite traditional Chinese medicine dentifrice. The key point of the technical proposal of the invention is that the attapulgite traditional Chinese medicine dentifrice consists of purified attapulgite clay, attapulgite clay with activity, herba cirsii japenici, flos sophorae, hawthorn, baked rhizoma zingiberis, rhizoma imperatae, Chinese arborvitae twig, notoginseng, licorice, borneol and lauryl sodium sulfate. After being mixed, ingredients of the attapulgite traditional Chinese medicine dentifrice are put into a crusher to be crushed, and crushed mixture is transferred to a superfine comminuter to be ground and then packaged into finished attapulgite traditional Chinese medicine dentifrice product. The attapulgite traditional Chinese medicine dentifrice has good stability and foaming power, and is non-caking, cool and refreshing. The attapulgite traditional Chinese medicine dentifrice has good absorption, can absorb and remove various odors in the oral cavity, reduce dental plaque and gum bleeding effectively, and also contributes to oral diseases prevention. The invention is suitable for eliminating halitosis and preventing oral diseases.
BACKGROUND: Androgenic alopecia (AGA) is the most common non-scarring alopecia disorder. Given its increasing incidence and onset during adolescence, AGA significantly impacts both the physical and psychological well-being of affected individuals. Emerging evidence suggests a pivotal role of metabolites in AGA. This study aims to elucidate the causal relationship between metabolites and AGA using Mendelian randomization (MR) analysis.
METHODS: We conducted a two-sample Mendelian randomization (TSMR) analysis based on a genome-wide association study (GWAS) to assess the causality of 452 metabolites on AGA. The main approach employed for inferring causal effects was inverse variance weighted (IVW), which was complemented by MR-Egger regression, weighted median, as well as MR pleiotropy residual sum and outlier (MR-PRESSO) approaches. Additionally, sensitivity analyses were performed to ensure result robustness. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs) in GWAS dataset comprising 452 metabolites.
RESULTS: Notably, we identified Scyllo-inositol and Alpha-ketoglutarate as the most potent protective factors against AGA, while Heme* and 2-palmitoylglycerophosphocholine* emerged as significant risk factors for AGA. Furthermore, sensitivity analysis revealed no heterogeneity in these findings.
CONCLUSIONS: Overall, our research suggests a potential causal link between metabolites and AGA, offering a more comprehensive insight into the pathogenesis of AGA and present additional strategies for prevention and treatment.
INTRODUCTION: Delayed Cerebral Ischemia (DCI) is a significant complication following aneurysmal subarachnoid hemorrhage (aSAH) that can lead to poor outcomes. Machine learning techniques have shown promise in predicting DCI and improving risk stratification.
METHODS: In this study, we aimed to develop machine learning models to predict the occurrence of DCI in patients with aSAH. Patient data, including various clinical variables and co-factors, were collected. Six different machine learning models, including logistic regression, multilayer perceptron, decision tree, random forest, gradient boosting machine, and extreme gradient boosting (XGB), were trained and evaluated using performance metrics such as accuracy, area under the curve (AUC), precision, recall, and F1 score.
RESULTS: After data augmentation, the random forest model demonstrated the best performance, with an AUC of 0.85. The multilayer perceptron neural network model achieved an accuracy of 0.93 and an F1 score of 0.85, making it the best performing model. The presence of positive clinical vasospasm was identified as the most important feature for predicting DCI.
CONCLUSIONS: Our study highlights the potential of machine learning models in predicting the occurrence of DCI in patients with aSAH. The multilayer perceptron model showed excellent performance, indicating its utility in risk stratification and clinical decision-making. However, further validation and refinement of the models are necessary to ensure their generalizability and applicability in real-world settings. Machine learning techniques have the potential to enhance patient care and improve outcomes in aSAH, but their implementation should be accompanied by careful evaluation and validation.
BACKGROUND: The associations of risk factors with vascular impairment in type 1 diabetes patients seem more complex than that in type 2 diabetes patients. Therefore, we analyzed the associations between traditional and novel cardiovascular risk factors and vascular parameters in individuals with T1D and modifications of these associations according to sex and genetic factors.
METHODS: In a cross-sectional study, we analyzed the association of risk factors in T1D individuals younger than 65 years using vascular parameters, such as ankle brachial index (ABI) and toe brachial index (TBI), duplex ultrasound, measuring the presence of plaques in carotid and femoral arteries (Belcaro score) and intima media thickness of carotid arteries (CIMT). We also used photoplethysmography, which measured the interbranch index expressed as the Oliva-Roztocil index (ORI), and analyzed renal parameters, such as urine albumin/creatinine ratio (uACR) and glomerular filtration rate (GFR). We evaluated these associations using multivariate regression analysis, including interactions with sex and the gene for connexin 37 (Cx37) polymorphism (rs1764391).
RESULTS: In 235 men and 227 women (mean age 43.6 ± 13.6 years; mean duration of diabetes 22.1 ± 11.3 years), pulse pressure was strongly associated with unfavorable values of most of the vascular parameters under study (ABI, TBI, Belcaro scores, uACR and ORI), whereas plasma lipids, represented by remnant cholesterol (cholesterol - LDL-HDL cholesterol), the atherogenic index of plasma (log (triglycerides/HDL cholesterol) and Lp(a), were associated primarily with renal impairment (uACR, GFR and lipoprotein (a)). Plasma non-HDL cholesterol was not associated with any vascular parameter under study. In contrast to pulse pressure, the associations of lipid factors with kidney and vascular parameters were modified by sex and the Cx37 gene.
CONCLUSION: In addition to known information, easily obtainable risk factor, such as pulse pressure, should be considered in individuals with T1D irrespective of sex and genetic background. The associations of plasma lipids with kidney function are complex and associated with sex and genetic factors. The decision of whether pulse pressure, remnant lipoproteins, Lp(a) and other determinants of vascular damage should become treatment targets in T1D should be based on the results of future clinical trials.
The present invention relates to Cannabidiol (CBD) and 5-HT 2B Use of a combination of receptor agonists. Such a combinationProvide for the treatment of 5-HT 2B Protection of adverse effects caused by receptor agonists. The invention also relates to the use of a combination of a CBD and amphetamine or an amphetamine derivative for the treatment of epilepsy. In one embodiment, CBD is used in combination with the amphetamine derivative fenfluramine to produce a significant reduction in seizures. Preferably, the CBD used is in the form of a highly purified extract of cannabis (cannabis) such that the CBD is present at greater than 98% (w/w) of the total extract and is characteristic of other components of the extract. In particular, the cannabinoid Tetrahydrocannabinol (THC) has been substantially removed to a level of no more than 0.15% (w/w), and the propyl analogue of CBD is present in an amount of up to 1% of Cannabidivarin (CBDV). Alternatively, the CBD may be a synthetically produced CBD. In CBD and 5-HT 2B When the receptor agonist is used in combination, amphetamine or an amphetamine derivative may be formulated for administration separately, sequentially or simultaneously with amphetamine or an amphetamine derivative, or the combination may be provided in a single dosage form. When the CBD is formulated for separate, sequential or simultaneous administration, it may be provided as a kit, or with instructions to administer one or more of the components in the manner indicated.
All colorectal polyps up to 10 mm found except for tiny hyperplastic polyps in the rectum and distal sigmoid colon are removed using an exclusive cold polypectomy snare (Exacto cold snare). The technique is cold snare resection of the polyp without tenting without electrocautery and then suction of the transected polyp into a trap followed by submission to the histological evaluation. The hemostatic clipping is not performed after cold snare polypectomy.
Two probiotic strains will constitute the experimental arm (Probiotics). Patients will take two capsules a day (one closed capsule to swallow and one open capsule mixed with maple syrup) from Day 1 to Day 10 and one closed capsule to swallow from Day 11 to Day 25.They will stop the treatment if they are admitted to the hospital. The treatment will last a maximum of 25 days.
Adult patients with a histologically or cytologically documented advanced NSCLC not amenable to curative surgery or radiation with tumors that lack activation EGFR mutations and ALK fusions are eligible for enrollment. During the initial therapy phase, patients will receive treatment with Durvalumab along with the Investigator's choice of platinum-based doublet therapy for squamous NSCLC (nab-paclitaxel plus carboplatin or gemcitabine plus carboplatin/cisplatin) and non-squamous NSCLC (nab-paclitaxel plus carboplatin or pemetrexed plus carboplatin/cisplatin) for 4 cycles. Patients who have completed 4 cycles and not progressed throughout the initial therapy phase will be randomized in a 1:1 ratio into the maintenance phase of the study to receive either Durvalumab plus placebo or Durvalumab plus Olaparib maintenance therapy. Patients will receive maintenance treatment until specific discontinuation criteria are met, including clinical disease progression (as assessed by the Investigator) or RECIST 1.1-defined radiological Progressive Disease (PD), unacceptable toxicity, and withdrawal of consent. Tumor evaluation scans will be performed until objective disease progression as efficacy assessments. All patients will be followed for survival until the end of the study.
PURPOSE:The titled ameliorant, containing a solubilized collagen as an active constituent, capable of activating and improving the peripheral blood circulation insufficiency, stabilizing the blood corpuscular cells and eliminating the circulation insufficiency, etc., and suitable for injection. CONSTITUTION:An injection containing a solubilized collagen as an active constituent. The friction between the blood corpuscular cells and blood vessels plays an important role in the blood stream in the microcirculation, and various diseases, e.g. peripheral arterial thrombosis, phlebothrombosis or ischemic heart diseases, are considered to be induced and exacerbated by the deterioration in the cellular lubricating action. The solubilized collagen prevents the coagulation, agglutination and hemolysis of the blood solid components, e.g. erythrocytes, leukocytes or blood platelets, and facilitates the passage or permeation in capillaries, microblood vessels, artificial membranes, extracorporeal circulation apparatuses, etc., prevents the stay in fine gaps, stabilizes the blood cellular membranes and activates the microcirculation of blood corpuscular components. The collagen is easily obtained by solubilizing the skin tissues, bones, etc. of animals.
OBJECTIVE: Elderly patients undergoing spinal surgery are at an increased risk of morbidity and mortality. Evaluating frailty and preoperative status is crucial for predicting postoperative outcomes. This study aimed to assess the predictive value of the modified Frailty Index (mFI), sarcopenia, Prognostic Nutritional Index (PNI), and Geriatric Nutritional Risk Index (GNRI) in determining postoperative complications in patients undergoing oblique lumbar interbody fusion (OLIF) over 60 years.
METHODS: Preoperative risk factors were assessed using 11 variables, including mFI, PNI, and GNRI. Complication rates were compared among nonfrail (mFI=0; n=50), prefrail (mFI=0.09-0.18; n=144), and frail (mFI ≥0.27; n=80) patients. Demographic and perioperative variables were compared between the complication and noncomplication groups. The incidence of complications was the primary outcome measure.
RESULTS: Complications occurred in 36 of 274 patients (13.1%). The frail group exhibited a significantly higher incidence of pneumonia than the nonfrail and prefrail groups. The complication group displayed significant differences in several variables, including age, fusion level, albumin level, lymphocyte count, platelet count, creatinine level, and estimated blood loss. Moreover, mFI, PNI, and GNRI differed significantly between the complication and noncomplication groups.
CONCLUSIONS: MFI, PNI, and GNRI can be useful for predicting postoperative morbidity and mortality in patients undergoing OLIF. These comprehensive assessment methods enable the identification of high-risk patients and the formulation of tailored strategies to enhance postoperative outcomes. Integrating mFI, PNI, and GNRI into the preoperative evaluation process can help health care providers proactively manage high-risk patients, thus improving the overall quality of care for elderly individuals undergoing OLIF.
This study investigates if prolonged exposure is an effective treatment in reducing PTSD symptoms people who have recently experienced trauma. The study will also investigate predictive markers of PTSD, moderators of successful treatment and health economic aspects of the intervention.

Participants will first undergo an evaluation session that will include an interview (Immediate Stress Reaction Checklist) and questionnaires. Participants will subsequently be randomly assigned to receive either modified prolonged exposure therapy or attention control, starting the assigned intervention immediately. Participants in each arm will receive three weekly treatment sessions. Treatment will involve psychoeducation about common reactions to trauma, imaginal exposure (revisiting memories of a recent trauma out loud with a therapist and audio-recording these for review at home), exposure in vivo and breathing retraining. All participants will undergo assessments 2, 6 (primary endpoint) and 12 months after the intervention by blinded assessors. Patients unable to come to the clinic for follow-up assessments will be interviewed via telephone or skype. Source data will be quality monitored by an independent party (Karolinska trial alliance) according to the Helsinki Declaration.
There have not been sufficient numbers of geriatric patients involved in clinical trials utilizing norethindrone acetate and ethinyl estradiol to determine whether those over 65 years of age differ from younger subjects in their response to norethindrone acetate and ethinyl estradiol.

In the Women’s Health Initiative Memory Study, including 4,532 women 65 years of age and older, followed for an average of 4 years, 82% (n = 3,729) were 65 to 74 while 18% (n = 803) were 75 and over. Most women (80%) had no prior hormone therapy use. Women treated with conjugated estrogens plus medroxyprogesterone acetate were reported to have a two-fold increase in the risk of developing probable dementia. Alzheimer’s disease was the most common classification of probable dementia in both the conjugated estrogens plus medroxyprogesterone acetate group and the placebo group. Ninety percent of the cases of probable dementia occurred in the 54% of women that were older than 70. (See WARNINGS, Dementia.)
Obesity is the result of positive energy balance in which various hormones and neurotransmitters are involved. Using Dietary supplements is a common and popular method to lose weight. Medicinal plants with specific effects on metabolizing enzymes, blocking adipogenesis, and improving energy metabolism can be a suitable alternative to these supplements. In this study, the role of hydro-alcoholic extract of Dactylorhiza maculate (Salep) plant on obesity and its related hormones and antioxidants was investigated. Forty male Wistar rats were divided into five groups: Control, Sham, and Salep extract (three doses): 80, 160, and 320 mg/kg. The extract was fed by gavage for 29 days. After the 29th day, blood and tissue samples were taken. Rats' ELISA kits were used to measure adiponectin, obestatin, resistin, orexin-A, insulin, epinephrine, Agouti Related Neuropeptide (AgRP), omentin, chemerin, amylin, neuropeptide-Y (NPY), and ghrelin. In addition, we measured leptin, cholecystokinin (CCK), antioxidants, and lipid profile factors. Evaluation of weight changes showed that Salep extract helped the animals to lose weight significantly in the 160 and 320 mg/kg Salep groups. Leptin, adiponectin, AgRP, obestatin, CCK, chemerin, adiponectin, and total antioxidants displayed a significant increase compared to the control group. In contrast, ghrelin, omentin, resistin, NPY, amylin, orexin-A, epinephrine, and Malondialdehyde (MDA) decreased in the Salep groups. The lipid profile was also affected by the extract. These findings suggest that the Salep extract prevents appetite, reduces ghrelin, and affects digestive factors; the Salep extract can change the secretory factors of adipose tissue and lipid profile and ultimately help to lose weight.