anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To produce a porous calcium carbonate based compd. consisting of particles exhibiting a specified property and excellent in dispersibility, transparency, oil absorptivity, moisture retention, etc., by allowing the calcium carbonate to react with a phosphoric acid based compd. SOLUTION: The calcium carbonate is allowed to react with the phosphoric acid based compd. (e.g. KH2 PO4 ). In this way, the porous calcium carbonate based compd. consisting of the particles which satisfies formula I, II, III, IV, V and VI is obtained. In each formula, dx is an average grain size (μm) calculated with an electronmicrograph; α is a dispersion coefficient; β is sharpness and particle size distribution, and the smaller the value, the sharper the particle size distribution; Sw is a BET specific surface area (m<2> /g) by a nitrogen adsorpting method; (x) is an oil absorption (ml/100g) and calculated by JIS K5101; (y) is a water absorption (cc/100g) and calculated by JIS K5101-19 by using water after taking 5g sample on an exclusive glass plate for calculating the oil absorption whose center is like a ground glass.  The obtained porous compd. is suitable for cosmetics.
The utility model relates to an article in daily life, particularly an inflation towel with Chinese herb medicine. The utility model is suitable for outgoing and tour, with the functions of killing bacteria and fungi. The utility model solves the problems that a tourist can carry the inflation towel with Chinese herb medicine conveniently, and the inflation towel with Chinese herb medicine can effectively kill bacteria and fungi. The inflation towel with Chinese herb medicine has main technical characteristics that one layer Chinese medicine powder layer is added between a cake-shaped towel. The thickness of the layer ranges from 0.5 mm to 5 mm. Then, finished products are packed by heat-shrinkable films. The inflation towel with Chinese herb medicine has the washing function, and also has the effects of hygiene, convenience, sterilization, body building, clear and activate the channels and collaterals, absorbing clots, relieving itching, etc. The inflation towel with Chinese herb medicine can also effectively prevent and treat skin diseases and skin diseases caused by fungal infection.
PURPOSE: To obtain a sustained release formulation, comprising a granule containing a core comprising a pharmacologically active substance coated with a specific polymeric mixture and an effervescent or a water-dispersible ingredient and administrable in a large dose to a patient. CONSTITUTION: This granular sustained release formulation in the form of a tablet comprises (A) a granule, containing a core comprising (A1 ) a pharmacologically active substance (e.g. ibuprofen, nifedipine or mefenamic acid) and an excipient and (A2 ) a coating substance composed of 100 pts. acrylic polymer which covers the surface of the core and is insoluble in water but swellable with water in an amount of 2-25% based on the weight of the core and 20-70 pts. water-soluble hydroxylated cellulosic derivative (e.g. hydroxyopropyl cellulose containing methoxyl groups having 20-30% substitution degree and hydroxy groups having 7-12% substitution degree) and having preferably 0.5-2.5mm, especially preferably 0.7-1.2mm diameter and (B) an effervescent ingredient (e.g. sodium bicarbonate and an organic acid) or a water-dispersible ingredient (e.g. mannitol).
The invention discloses a cosmetic composition and its use and preparation technology. Each 100g of the cosmetic composition contains 5-25g of an amino acid surfactant and the balance polyol. Through use of a proper amount of plant grease, polysaccharide humectant, plant extract, ampholytic surfactant and pH regulator in the cosmetic composition, functions can be further optimized. The cosmetic composition can be directly used as a skin cleaning product or a skin makeup removing product, can also be used as a humectant and an emulsifier in a skin care product, and is natural and environmentally friendly. The cosmetic composition has the characteristics of strong decontamination capacity, good affinity, no irritation and no tension feeling when being used as face-cleaning and makeup-removal personal care products. After use, the cosmetic composition makes skin fresh, comfortable and moist.
The care team consists of four nurses, two of whom are employed by the region and two by the municipality, 20 municipally employed assistant nurses and one physician. Other professions associated with the team are psychologist, dietitian, pharmacist, counsellor, physiotherapist, occupational therapist, and family consultants. All participants in the team will be invited to participate in the study. The technology will be place in 20-25 patients' home and patients and family members will be invited to participate in the study. Self-care education will be given to the patients and family members according to the middle-range theory of self-care of chronic illness.
FIELD: medicine.SUBSTANCE: invention refers to medicine, radiation diagnostics and can be used for 3D modeling for 3D printing when planning resections of pancreas in patients with tumor involvement. It is followed by CT with intravenous bolus contrast enhancement of hepatopancreatibiliary zone by low-dose protocol to obtain phases of maximum density gradient in arteries and veins of portal system. Obtained CT images are loaded into Myrian program and anatomical segmentation of image is performed. In the first phase of contrast amplification, the arterial bed is separated, in the second phase – the portal system. 3D area of interest is created and an automatic "hepatic artery" protocol is used to isolate the arteries of the celiac-mesenterial system, as well as an automatic protocol for the portal vein "portal vein, solid filter" separation. Pancreas is separated into a phase of maximum gradient with surrounding healthy tissues. Further, the tumor is recovered using the three-dimensional interpolation method with delineation of the formation at several levels depending on the size and shape. Obtained areas of interest: arteries, veins, and tumor are displayed on one screen of three-dimensional rendering called "surface area of interest" by transportation of missing object from other phase of contrast amplification. Obtained virtual model is evaluated for presence of errors in the image by comparison with axial CT sections. Further, the obtained three-dimensional model is stored in segmentation format and loaded into the Materialize program to create a three-dimensional printing file STL-file. Obtained file is loaded into 3D print program FlashPrint and sent to 3D printer FlashForge Dreamer. On the obtained three-dimensional model, supporting structures which were created automatically in FlashPrint are deleted.EFFECT: method provides planning of pancreatic resections in patients with tumor involvement by printing a three-dimensional model of the region of interest.1 cl, 11 dwg, 1 ex
Patients in this arm will receive 40 sessions of sham rTMS. They will be set up the same as the active Bulimia Nervosa group however their will be no actual brain stimulation.
The invention relates to a microalga screening method, and concretely relates to a freshwater microalga and an application thereof. A microalga strain is a freshwater microalga strain Didymogenes sp. HN-4, is preserved on Oct. 24, 2013, and has a preservation number of CGMCC No.8401. The microalga strain is used for producing oil, biodiesel, algal proteins, fatty acids or biomasses. The invention also discloses growth conditions and oil contents of the microalga strain under different medium components. The application of the microalga provides an environmentally-friendly cheap technology for producing biodiesel and reducing insect pests of microalgae.
The present invention discloses plantain seed health care tea. The present invention is prepared by the method that chrysanthemum flowers, gastrodia tubers, pagodatree flowers, wolfberry fruits, dogwood fruits and plantain seeds are proportioned according to certain weight. The health tea has the effects of liver moistening, kidney benefiting, calming endogenous wind for improving eyesight and dampness and phlegm elimination. The present invention has the advantages of low cost, good effect, reasonable formula, simple preparation, easy preservation, use in four seasons, disease treatment, health care, convenient drinking and good mouth feel. The tea is suitable for patients who have the disease symptoms of dizziness, tinnitus aurium, little ruber lichen, small and wiry pulse, blurred vision, shortage of liver and kidney, headache, etc. to drink. The present invention is a quite ideal health care drinking product with the functions of liver moistening, kidney benefiting, endogenous wind calming for improving eyesight and dampness and phlegm elimination.
The investigators propose a trial to test the effects of Incentive Therapy (IT) and Other Therapeutic and Supported Employment Services (Other TSES) on improving SUD outcomes in newly recovering Veterans in outpatient treatment. In line with eligibility criteria for different TSES programs, the investigators will employ a two branch study: One branch will be for Veterans who are not interested in pursuing competitive employment, and will be a two arm RCT with randomization (2:1) to referral for IT + treatment as usual (TAU; including usual SUD outpatient treatment) or TAU alone. The second branch will be for Veterans who express interest in competitive employment, and will be a two arm RCT with randomization (2:1) to referral for TSES competitive employment services + TAU or TAU alone. Total Intent to Treat sample will be 140 (n=70 per branch). Primary outcomes will be percent days abstinent during 3 month active phase and clinical global impression scale scores at 6 months. Secondary outcome will be psychiatric symptoms, self esteem/efficacy and quality of life.
PURPOSE:In the production of a stick cosmetic composed of a sintered and formed inorganic pigment and a cosmetic component impregnated in the pore of the sintered material, the collapse of the cosmetic at the part held with a holder is prevented by applying a reinforcing material to the holding part and solidifying the material. CONSTITUTION:In the production of a stick cosmetic (e.g. eyeliner, eyebrow pencil, etc.) composed of a sintered and formed inorganic pigment and a cosmetic component (e.g. higher alcohol, higher fatty acid, wax, liquid paraffin, etc.) impregnated in the pore of the sintered material, the part of the cosmetic held with a holder is coated with a reinforcing material and solidified to prevent the collapse of the held part. The reinforcing material is e.g. a solution of acrylonitrile-styrene copolymer resin, polyvinyl alcohol, etc., in a solvent, molten polyethylene, etc., UV-curable material, etc. The ends of a number of cosmetic sticks having definite shape are placed on a plane, dipped in a liquid reinforcing material by definite lengths, and solidified to obtain reinforced cosmetic sticks.
This study is a dose escalation study which adopts the 3+3 dose escalation design protocol. The dose is respectively 3.0×10\^9 cells, 5.0×10\^9 cells and 7.0×10\^9 cells. The administration is performed on day 1 and day 8 of each cycle (21 days). 3-6 subjects will be enrolled at every dose level. The first and second subjects in the same group shall be enrolled at an interval of at least 7 days, for the purpose of ensuring their safety. Only when the dose-limiting toxicity (DLT) of all subjects in the previous dose group was observed can the enrollment of the next dose group get started.
PURPOSE:To provide a pressure impression material capable of taking a dynamic impression suiting the function of e.g. chewing motion to form an artificial denture applying uniform biting pressure to the alveolar crest in chewing motion and effective for eliminating the problems such as the oppressive pain of the protruded part of bones. CONSTITUTION:The objective pressure impression material taking solid state at room temperature and plasticized at 37 deg.C to cause the deformation and shift of the material by the application of biting pressure is produced by using one or more materials selected from polyethyl methacrylate, polymethyl methacrylate, polyvinyl acetate, polybutyl methacrylate, polyisobutylene, etc., as main components. Since the material is plasticized at 37 deg.C, it exhibits plasticity and flowability when inserted into oral cavity and is resistant to hardening with time and, accordingly, a dynamic impression suiting the function of chewing motion can be taken by this material. The impression material 2 is sealed on the surface of mucosa (the inner face of the artificial denture 1) with a mucosa-regulation material 3 and deformed and shifted by biting to uniformly disperse the pressure applied to the mucosa. As a result, the pressure on the surface of the mucosa is uniformized to eliminate the problems such as the oppressive pain of the protruded part of bones.
A vein thromboembolism (VTE) risk assessment system that includes a casing having a shape adapted to secure a plurality of components with the casing. The casing includes a microphonic sensor, a Photoplethysmography (PPG) sensor, an Inertial Measurement Unit (IMU) sensor, a diaphragm, and a microcontroller. The microphonic sensor captures VTE audio signals indicative of the VTE risk of the user. The PPG sensor measures blood volume changes in a skin area in response to venous hemodynamic changes in a lower limb. The IMU sensor captures seismic signals indicative of the VTE risk of the user. The diaphragm enhances auscultation signals. The microcontroller transmits data to a computing device.
A scaffold for use as a growth supportive base for cells and tissue explants is formed of naturally occurring derived connective or skeletal tissue that has been treated for elimination of cellular and cytosolic components comprising DNA, RNA, peptides, lipids and proteoglycans. The treated tissue can be crosslinked and treated for producing a higher porosity such as by mechanical or chemical treatment. Alternatively, the treated tissue is ground to form flakes having a size below 1000μ, and the flakes are attached to each other to provide a scaffold having a porosity of at least 85%. The scaffold may be composed of several single-flake layers arranged on top of the other. The scaffold can be impregnated with cells to form tissue such as epiphysial tissue, and may contain adhesive molecules or growth factors. A prosthesis for implanting can be formed using the scaffold. The scaffold may be composed of fused epiphyses.
BACKGROUND: Eradication for Helicobacter pylori usually induces digestive dysbiosis that, in turn, elicits symptoms. Consequently, probiotic supplementation may counterbalance the disturbed microbiota after this procedure. So, probiotics may restore microbiota homeostasis quickly relieve complaints.
METHODS: The current study evaluated the efficacy and safety of Abivisor®, a food supplement containing Lacticaseibacillus rhamnosus LR06 (3 billion living cells), Lactiplantibacillus pentosus LPS01(100 million living cells), Lactiplantibacillus plantarum LP01 (1 billion living cells), and N-acetyl cysteine (60 mg). Patients were randomized into two groups (2:1). Group A took one stick/daily for 60 days after eradication. Group B was considered as control. Patients were evaluated at baseline (T0) and after 15 (T1), 30 (T2), and 60 (T3) days. The severity of digestive symptoms was measured by patients using a Visual Analog Scale. The percentage of patients with each symptom was also evaluated.
RESULTS: Abivisor® has significantly and progressively diminished intestinal symptoms' presence and severity at T1, T2, and even more at T3. Accordingly, the percentage of symptomatic patients diminished more rapidly and significantly in group A than in B. All patients well tolerated the food supplement.
CONCLUSIONS: The present study suggests that Abivisor® may be an effective and safe therapeutic option for managing patients undergoing H. pylori eradication.
Approximately 6500 women will be screened, consented, and have the PreTRM® test sample collected. Randomization will occur 1:1 at each site. Those randomized to the Control arm will not receive the PreTRM® test results. Control arm subjects will continue on with standard of care.
The utility model provides Elsholtzia ciliata nebula, which is prepared from Elsholtzia ciliata oil or other plant extracts which can be combined, and auxiliary materials. The Elsholtzia ciliata comprises 1 to 99 parts of Elsholtzia ciliata oil, 10 to 50 parts of vegetable oil, 10 to 40 parts of carrier oil, 10 to 30 parts of a flavoring agent, 2 to 15 parts of a surfactant and 100 to 1000 parts of purified water. The components are fully and uniformly mixed to prepare the nebula. The medicinal nebula can be directly sprayed to the nasal cavity or the pharyngeal portion. The nebula can reach the diseased parts directly without being absorbed by gastrointestinal tracts, and act on mucous membrane so that the medicine can directly play a local role. The Elsholtzia ciliata nebula is used safely and carried conveniently.
The LH-RH receptor antagonists containing cyclic pentapeptides or salt thereof and novel cyclic pentapeptide or salts thereof are provided. The LH-RH receptor antagonists of the present invention are effective as medicines for preventing and curing sex hormone-dependent cancers (eg. prostatic cancer, uterine cancer, mammary cancer, pituitary tumor, etc.) prostatomegaly, endometriosis hysteromyoma, puberty precox, amenorrheal syndromes, multilocular ovarian syndromes, comedo, etc, and are also effective as pregnancy controlling agents (e.g., contraceptives, etc.) and menstrual cycle controlling agents. Moreover, these are also useful in the livestock industry for the control for the estrus of animals and also for the improvement in the quality of meat and for the control of the growth of animals, as well as in the marine products industry as spawning promoters for fishes.
PURPOSE:To provide a safe cosmetic to be used for the promotion of blood flow and metabolism of skin and containing apricot extract, honey and optionally further a humectant such as royal jelly. CONSTITUTION:The objective cosmetic is produced by compounding various components to apricot extracts and honey. The cosmetic preferably further contains a humectant to impart moist feeling to the skin surface. The humectant is preferably royal jelly, sodium dl-pyrolidonecarboxylate, etc. Apricot extract contains vitamins, minerals and amino acids and is capable of supplying nutrients to the skin, adjusting the pH of the skin in weakly acidic state and keeping the skin in excellent state. The extract is also effective in improving the tackiness of the cosmetic. Honey has high viscosity to impart viscosity to the cosmetic and plays the role of antiseptic. The cosmetic is effective in promoting the blood flow, activating the metabolism and rejuvenating the skin.
Participants will be administered a single encapsulated dose of the test formulation (Model Naltrexone 50mg containing 2-butanol). Breath samples will be taken over 90 minutes (-5, 0, 5, 10, 20, 40, 60, 90). Subjects will then be randomly crossed over to the four interventions (Formulation 1, Formulation 2, Formulation 3, Formulation-free positive control) three formulations from the first part of the study and a control administration (a capsule-in-capsule design).
PURPOSE:To obtain a composite resin tooth having high physical strength (wear- resistant strength), excellent aesthetic appreciation, neither coloring nor changing color in an environment in oral cavity, having excellent water absorption resistance. CONSTITUTION:A composite resin tooth contains an inorganic filler in a cured resin and is molded into a given tooth shape. The resin comprises a polymer obtained by dispersing 1-20 pts.wt. fluoroalkyl group-containing polymerizable compound and 10-60 pts.wt. urethane dimethacrylate copolymer into 10-90 pts.wt. inorganic filler having 5-70mum and polymerizing the compound in the dispersed state.
The invention provides an oyster myosphere recombinant protein with low sensitization and a preparation method and application thereof. The invention provides a oyster myoglobin recombinant protein with hypoallergenic property, and the recombinant protein has the amino acid sequence shown in SEQ ID NO: 2. SEQ ID NO: 3. SEQ ID NO: 4. SEQ ID NO: 5, or a pharmaceutically acceptable salt thereof. The recombinant protein provided by the invention reduces the allergenicity of the oyster tropomyosin by modifying the amino acid in the allergen linear epitope of the oyster tropomyosin, and can be used for clinical immunotherapy of shellfish allergy patients.
PURPOSE: To obtain a dental resin composite of high safety by adding a specific amount photopolymerization initiator to a monomer mixture of tetrahydrofurfuryl methacrylate and specific methacrylates at a specific ratio. CONSTITUTION: To 100 pts.wt. of monomer mixture of 10-40 pts.wt. of tetrahydrofurfuryl methacrylate and 90-60 pts.wt. of at least one or more kinds of specific methacrylates having at least one or more unsaturated double bonds in the molecule, is formulated 0.004-0.12 pts.wt. of a photopolymerization initiator. This adhesive has a proper viscosity, shows no color remaining and excellent handling and aesthetical point and has sufficient adhesive strength and is used safely in oral cavity. This resin composite can be used to pile up an unpolymerized acrylic resin composite on a polymerized acrylic resin component such as a hard resin or a resin composite.
BACKGROUND: Acute kidney injury (AKI) has a complex pathophysiology and imposes serious health concerns worldwide. Extracellular vesicles (EVs) derived from induced mesenchymal stem cells (iMSCs) have been recognized as novel cell-free therapeutics for various inflammatory and degenerative disorders. In this study, we investigated whether iMSCs stimulated with a pan-peroxisome proliferator-activated receptor (PPAR) agonist could enhance the therapeutic efficacy of EVs against AKI.
METHODS: Human iMSCs were primed with or without lanifibranor, a PPAR agonist for 24 h, and EVs were collected after an additional 24 h. The basic characteristics of EVs were evaluated using cryo-transmission electron microscopy imaging, immunoblot detection of EV markers, nanoparticle tracking analysis, and localization in AKI kidneys. In vitro, the potential of the EVs to promote the growth and survival of HK-2 cells undergoing cisplatin-induced apoptosis and anti-inflammatory effects in M1-polarized THP-1 was compared. Subsequently, AKI was induced in BALB/c mice using cisplatin. After 8 and 24 h of cisplatin treatment, iMSC-EVs or pan-PPAR-iMSC-EVs were injected intravascularly. At 96 h after cisplatin administration, the renoprotective effects of iMSC-EVs or pan-PPAR-iMSC-EVs in inhibiting inflammation and apoptosis were compared using serum biochemistry, histology, immunohistochemistry, and gene expression analysis by qPCR.
RESULTS: Both EV types expressed EV markers and had typical EV morphology, and their localization in the renal tissue was confirmed. The proliferation and survival of HK-2 cells were higher in pan-PPAR-iMSC-EVs than those in iMSC-EVs. In M1-polarized THP-1 cells, the reduction in the mRNA expression of inflammatory cytokines was more significant in pan-PPAR-iMSC-EVs than that in iMSC-EVs. In the mouse model of cisplatin-induced AKI, pan-PPAR-iMSC-EVs markedly enhanced renoprotective effects compared to iMSC-EVs. Specifically, pan-PPAR-iMSC-EVs reduced tissue inflammation, immune cell infiltration, and apoptosis. Pan-PPAR-iMSC-EVs also increased renal capillary density.
CONCLUSION: Priming iMSCs with a PPAR agonist significantly improved the therapeutic potential of EVs by reducing inflammation and apoptosis. The reported strategy may contribute to the development of a novel cell-free option for AKI treatment.
TRIAL REGISTRATION: Not applicable.