anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a method for manufacturing a liposome by using woodiana pacifica anodonta as raw materials. The woodiana pacifica anodonta is called as HB for short, and an effective ingredient obtained from HB by proper extraction has an antineoplastic effect. Because HB is glucoprotein, the oral administration effect is poor, but the injection effect is good. In the method, the HB liposome is manufactured by HB, lecithin and cholesterol with a reverse phase evaporation method, and the antineoplastic effect is good according to a pharmacodynamics research result. The method has the advantages of simplicity and high product activity. An administration route of HB for suppressing a tumor is widened.
A polysaccharide graft polymer having the structure Sacch-O-(-G-)m-(M)n-1-M (I) in which Sacch- is a polysaccharide; m = 0 or 1; G is the residue of a polymerisable unsatd. monomer which is bonded to the polysaccharide by an ether or ester linkage; n is greater than 1; and M is the residue of one or more polymerisable, unsaturated monomers at least one of which is a siloxane-contg. monomer, which have been grafted to the polysaccharide or the Sacch-O-G polysaccharide deriv. by free radical polymerisation. Pref. in (I) G is derived from allyl glycidyl ether; and M has the structure in which Z = the residue of a polymerisable, unsaturated organic gp. which is bonded to the Si by a C-Si linkage; R1 = straight or branched 1-6C alkyl or alkenyl gp. or an aryl, aralkyl or alkaryl gp.; and R2 and R3 (same or different) straight or branched 1-6C alkyl or alkenyl or aryl, aralkyl or alkaryl gps. or alkoxides of straight or branched 1-6C alkyl or alkenyl gps. or aryl, aralkyl or alkaryl gps., or alkoxides in which R2 and R3 together for a cyclic structure of at least five members.
The study is a 12 week double-blinded, randomised, placebo-controlled food-based intervention trial in a real-life setting. 140 (18-50 y) women in risk of vitamin D deficiency and with Caucasian or South Asian origin. The two ethnic groups of women will each be randomised into two groups. One receiving vitamin D fortified foods and the other receiving the same kind of foods non-fortified. Foods given in the study period are free of charge for the participants and will be handed out every second week. The foods are eggs, yoghurt, cheese and crisp bread.

The study includes a baseline visit and a final visit, at both visits blood samples will be drawn, anthropometrics, muscle strengths, dietary and background questionnaires.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a serious chronic disease worldwide, with significant negative impacts on the quality of life, family economic burden, and social healthcare burden of patients.
AIMS: The aim of this study was to explore the effects of virtual reality technology on exercise function and lung function in COPD patients.
METHODS: A meta-analysis of randomized controlled trials was utilized. PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, CINAHL, Medline, Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Database, Weipu Database (VIP), and Chinese Biomedical Database (CBM) were systematically searched. We included randomized controlled trials published from the establishment of the database to August 10, 2022, on virtual reality technology in COPD patients. Literature retrieval and screening was carried out independently by two reviewers to obtain literature that met our inclusion and exclusion criteria and to extract relevant data. Two reviewers assessed the risk of bias in the included literature. A meta-analysis was performed using Revman 5.4 Software.
RESULTS: A total of 10 randomized controlled trials with 539 participants were included. The results showed that virtual reality technology significantly improved the lung function of COPD patients, such as forced expiratory volume (FEV1; MD = 7.29, 95% CI [4.34, 10.24], p < .01) and forced expiratory volume/forced vital capacity (FEV1/FVC; MD = 6.71, 95% CI [4.72, 8.71], p < .01). The combined intervention with different virtual reality technology had different effects on motor function. Compared with endurance training (ET) alone, virtual reality technology combined with ET had no significant effect on the 6-minute walk test (6WMT) in COPD patients (p > .05). Compared with pulmonary rehabilitation (PR) alone, virtual reality technology combined with PR was more effective in increasing 6WMT in COPD patients (MD = 30.80, 95% CI [10.85, 50.74], p < .01).
LINKING EVIDENCE TO ACTION: Virtual reality technology can help to improve lung function in COPD patients, and virtual reality combined with PR can improve exercise tolerance in COPD patients. However, due to the limited number of included studies, large-sample, multicenter, high-quality randomized controlled trial studies are needed to provide clear evidence.
Targeted drug delivery is an ongoing aspect of scientific research that is expanding through the design of micro- and nanoparticles. In this paper, we focus on spray dried microparticles as carriers for a repurposed lipophilic antioxidant (probucol). We characterise the microparticles and quantify probucol prior to assessing cytotoxicity on both control and cisplatin treated hair cells (known as House Ear Institute-Organ of Corti 1; HEI-OC1). The addition of water-soluble polymers to 2% β-cyclodextrin resulted in a stable probucol formulation. Ursodeoxycholic acid (UDCA) used as formulation excipient increases probucol miscibility and microparticle drug content. Formulation characterisations reveals spray drying results in spherical UDCA-drug microparticles with a mean size distribution of ∼5-12 μm. Probucol microparticles show stable short-term storage conditions accounting for only ∼10% loss over seven days. By mimicking cell culture conditions, both UDCA-probucol (67%) and probucol only (82%) microparticles show drug release in the initial two hours. Furthermore, probucol formulations with or without UDCA preserve cell viability and reduce cisplatin-induced oxidative stress. Mitochondrial bioenergetics results in lower basal respiration and non-mitochondrial respiration, with higher maximal respiration, spare capacity, ATP production and proton leak within cisplatin challenged UDCA-probucol groups. Overall, we present a facile method for incorporating lipophilic antioxidant carriers in polymer-based particles that are tolerated by HEI-OC1 cells and show stable drug release, sufficient in reducing cisplatin-induced reactive oxygen species accumulation.
1,176,194. Pharmaceutical preparations containing imipramines. GEIGY (U.K.) Ltd. 9 Aug., 1968 [12 Aug., 1967], No. 37136/67. Heading A5B. [Also in Division C3] A pharmaceutical preparation (providing immediate and rapid release of the therapeutic agent for oral administration) comprises a suspension or dispersion, in a carrier liquid which is substantially free of ions or ionisable material, of a solid compound formed from imipramine, chlorimipramine, 10-keto-imipramine, desimipramine or opipramol base and a cation-exchange resin in the form of a methacrylate polymer containing carboxyl groups and having a degree of cross-linkage from 1 to 10%. The base is combined with the resin by agitating the resin with a solution of the base, e.g. in an acetone/water or isopropanol/water mixture, in the proportion of base to resin from 10 to 50% on a dry weight to weight basis. The resin may be a polymethacrylic acid or a copolymer of methacrylic acid and divinyl benzene, preferably having a particle size in the range of from 1 to 150 microns. The base may be used in the form of a pharmaceutical grade free base or it may be set free from the corresponding salt, preferably the hydrochloride, by solvent extraction after making alkaline, or by passing through an anion-exchange resin column, e.g. a polystyrene type polymer containing quaternary ammonium groups and cross-linked with divinyl benzene. The carrier liquid medium may comprise water and may also contain one or more sweeteners, flavours, colloid thickening agents, colours and preservatives.
It is estimated that 20% to 35% of children and adolescents worldwide are affected by chronic pain. As a result of chronic pain, children may miss school, withdraw from social activities, and develop internalizing behaviors. Therefore, accurately identifying the cause of a child's pain is important for both proper treatment of the pain and to prevent problems secondary to the chronic pain. Evidence in the literature points strongly toward an involvement of the sigma-1 receptor in neurogenic inflammation, which is known to be an important pathophysiological mechanism for maintenance and perpetuation of chronic neuropathic pain. The investigators hope to image and identify activated pain pathways in pediatric pain paitents using a radiolabeled biomarker for increased S1R expression. By localizing and quantifying areas of increased S1R expression to sites of augmented nociceptive activity using hybrid molecular/anatomic imaging techniques, we will objectively identify sites of neurogenic inflammatory activity and pain generation. The ability to image the changes associated with chronic pain generating pathologies provides us with a tool to identify and measure the intensity of the pathology. Imaging S1R expression in chronic pain states in pediatric patients would be both novel in its application and extremely powerful in better characterizing pediatric pain.
PURPOSE:A membrane composition, containing a phospholipid and/or hydrogenated phospholipid, and having improved biodegradability and compatibility with living bodies. CONSTITUTION:A membrane composition obtained by dissolving a phospholipid derived from egg yolk or plant or/and a hydrogenated phospholipid in a solvent, e.g. hexane, lower aliphatic halogenated hydrocarbon such as chloroform or lower aliphatic alcohol such as ethanol, dispersing or dissolving an active substance, e.g. fat-soluble vitamin, water-soluble vitamin or nonsteroidal hormone, and drying the resultant dispersion or solution to give a film. The addition of a high polymer e.g. polybutene or chlorinated paraffin, or oily substance, e,g. liquid paraffin or squalane, permits the adjustment of strength, elasticity of the film and releasability of the active substance, etc. EFFECT:Improved affinity for the skin and excellent absorbability and solubility of the active constituent. The composition is very stable with time, and can be incorporated in a large amount even in the liquid form.
Systems, methods, non-transitory computer-readable mediums, and/or apparatuses are provided for determining a medication used by a patient. Label information for a medication may be determined. A source national drug code (NDC) associated with the medication may be determined. The source NDC may be validated. A product NDC and a normalized identifier may be determined. A brand name associated with the medication may be determined. One or more active ingredients associated with the brand name may be determined. A drug display name may be determined. The drug display name and active ingredient information for the one or more active ingredients may be displayed. A summary indicating an amount of the active ingredient may be displayed, for example, based on a medication diary.
One session of repetitive transcranial magnetic stimulation (rTMS) treatment at 1 Hz frequency will be applied to the contralesional dorsal premotor cortex. Application will be performed with Neurosoft-Neuro MS / D device. 90% of the motor threshold will be used in the stimulation. Stimulation is planned for a total of 25 minutes and a total of 1500 beats in the form of 1 Hz stimulation.
Parkinson's disease (PD) patients who suffered from dysphagia have reported significantly reduced quality of life. The swallow function is a multidirectional process that depends on complex neuro-muscular network. The function can be evaluated using instrumental, such as fibreoptic endoscopic evaluation of swallowing (FEES), videofluoroscopy, or well structured questionnaires. There are many questionnaire and scales for assessment of dysphagia in PD but very few have been validated. The study will assess the construct validity and reliability of the Turkish version of Swallowing Disturbance Questionnaire. The investigators developed the Turkish version of this questionnaire (SDQ-T), according to the cross-cultural adaptation guidelines. Two translators translated the SDQ into Turkish and a native English language speaker reverse-translated it into English. The back translation was sent to the original author for proofreading. The SDQ questionnaire consisted of 15 basic questions related with dysphagia symptoms in PD patients.
Life-style intervention in participants with high genetic risk score: The 3-year lifestyle intervention includes 7-9 group sessions (two additional group sessions for participants whose body mass index exceeds 28 kg/m2) on diet (healthy diet according to Nordic and Finnish nutrition recommendations emphasizing appropriate energy intake, meal frequency, consumption of fruits, vegetables and berries, quality of dietary fat and carbohydrates, including sugar and fiber intake) and physical exercise (brisk walking a minimum of 30 minutes per day at least five days a week or other types of exercise, e.g. cycling, cross-country skiing, housework such as leafs raking, resistance training).
CP-B participants take GZR 50 mg or GZR 100 mg + EBR 50 mg q.d. by mouth for 12 weeks (GZR dose chosen based on results of Part A CP-B arm).
PURPOSE:To readily carry out the examination of periodontal deseases such as gingivitis or periodontitis by reacting a specimen collected from the oral cavity with a substrate for measuring the activity of an alkaline phosphatase. CONSTITUTION:A substrate for measuring the activity of an alkaline phosphatase (preferably p-nitrophenyl phosphate, etc.) and an amine-based buffer solution (preferably diethanolamine buffer, etc.) at pH7.5-11 are added to a specimen collected from the oral cavity and reaction is carried out at 20-40 deg.C for 1 to 30min. Coloring is measured with an absorbance meter, etc., to carry out the objective examination. Furthermore, when only the activity of the alkaline phosphatase derived from a periodontal pathogenic germ is detected, the specimen is heat-treated at 45-70 deg.C for 1-15min and cooling pretreatment is then carried out.
The Centers for Medicare and Medicaid Services (CMS) has specifically targeted COPD hospital readmissions as a meaningful quality outcome that could result in financial penalties highlighting the significant impact of COPD on our overall health system. The growing availability of efficacious medication, stands in stark contrast to the poor health outcomes experienced by COPD patients. One possible explanation for this gap is low rates of medication adherence; some studies report that only 25% of COPD patients take at least 80% of their prescribed medications. Pharmacy refill records indicate that adherence to COPD medications is significantly lower than adherence rates seen in other chronic illnesses including hypertension, diabetes, and congestive heart failure. Significant negative long term health outcomes may be magnified by non-adherence to prescribed medications in COPD.

This study proposes to systematically identify modifiable determinants of adherence in COPD based on the Theory of Self-Regulation in 360 patients with COPD. A novel and significant innovation of this study is the use of mobile health (mhealth) technology to objectively assess medication use. No previous study of self-regulation theory has utilized objective measure of adherence. A further innovation of the study is the use of ecological momentary assessment (EMA) of patient reported symptoms and beliefs to evaluate longitudinal associations between observation (patient symptoms) judgements (medication use to relieve symptoms), and reactions (self-efficacy, outcome expectancy, and medication beliefs) in real time. This study will be the first to objectively evaluate the application of the Self-Regulation Theory in COPD and to examine the long-term longitudinal impact of medication adherence on disease progression in a diverse sample.
Myotonic dystrophy type 1 is an autosomal dominant condition due to a CTG repeat expansion in the myotonic dystrophy protein kinase (DMPK) gene. This multisystem disorder affects multiple organ systems. Hypogonadism in males affected by myotonic dystrophy is commonly reported; however, the effect on female hypogonadism remains controversial. A 19-year-old female was referred to our genetics clinic due to primary amenorrhea without any family history of similar symptoms. Initial genetics evaluation identified a variant of uncertain significance in IGSF10, c.2210T>C (p.Phe737Ser). Follow-up genetic evaluation via whole genome sequencing identified at least 100 CTG repeats in the DMPK gene, thus resulting in the diagnosis of myotonic dystrophy type 1. The patient remains otherwise asymptomatic from myotonic dystrophy. This is the first report that demonstrates primary amenorrhea as a possible presenting feature of myotonic dystrophy type 1, thus providing evidence supporting female hypogonadism in myotonic dystrophy type 1.
Provided is a traditional Chinese medicine formula for treating diabetes. Modern medicine thinks that a diabetic nephropathy is glomerulus microvascular lesions caused by a plurality of reasons, and finally leads to glomerular sclerosis, and main therapeutic principles of the diabetic nephropathy are anticoagulation and improvement of glomerulus haemodynamics. Traditional Chinese medicine thinks that the diabetes exists for a long time, vitality of patients is certainly and badly sapped, deficiency of both vital energy and yin is caused, the deficiency of the vital energy causes inability of blood transport, patients with the deficiency of the yin are obscure in blood movement, and are in aeipathia, kidneys of the patients are hurt, a syndrome of the diabetes is blood stasis when veins are hurt. The technical field includes that the traditional Chinese medicine formula which can be lucid yang, clean stomach fire, clear viscera gas, help produce saliva and slake thirst comprises the following ingredients and is manufactured by weight. Main ingredients of the traditional Chinese medicine formula for treating the diabetes comprise, by weight, 60g of gypsum, 15g of anemarrhenae, 30g of radix trichosanthis, 6g of coptidis rhizome, 3g of cooked rhubarb and 9g of fructus schizandrae. An auxiliary ingredient of the traditional Chinese medicine formula for treating the diabetes comprises 1000ml of water.
The invention relates to a traditional Chinese medicine combination and method for treating breast hyperplasia. According to the method, breast hyperplasia is treated by oral taking of traditional Chinese medicines and external application of a hot traditional Chinese medicine bag. The traditional Chinese medicine combination comprises 15-20 g of angelica sinensis, 15-20 g of parched white peony root, 15-20 g of honewort, 5-10 g of poria, 10-15 g of roasted atractylis ovata, 10-15 g of fructus forsythiae, 15-20 g of kelp, 15-20 g of marine algae, 10-20 g of pericarpium citri reticulatae viriole, 10-15 g of cantharides, 10-15 g of safflower, 10-15 g of roasted fructus aurantii immaturus, 10-15 g of edible tulip, 10-15 g of dandelion, 10-15 g of curcuma aromatica, 5-12 g of cornu cervi degelatinatum and 20-30 g of oysters. A patient takes a dose of the decoction of the traditional Chinese medicine combination twice every day. External application of the traditional Chinese medicine bag comprises the steps of bagging and decocting the orally taken traditional Chinese medicines and then externally applying the hot traditional Chinese medicine bag to an affected breast part. Oral taking of the traditional Chinese medicines can sooth the liver, relieve depression, promote blood circulation to remove blood stasis, clear blood stasis, relieve pain and achieve the effect of treating the root cause of breast hyperplasia; external application of the traditional Chinese medicine bag can play a role in softening hardness to dissipate stagnation and enabling the oral and external medicines to act on the focus quickly; and both symptoms and root causes of the breast disease can be treated by oral taking and external application, the efficiency is high, the treatment course is short, the possibility of relapse is low, and meanwhile, the body immunity is enhanced.
Participants receive PEG interferon alfa-2b 1.5 mcg/kg by SC injection OW for up to 40 weeks. They also receive 500 to 1000 mg of acetaminophen orally 30 minutes prior to PEG interferon alfa-2b administration, and 500 to 1000 mg afterwards every 4 to 6 hours as needed. Total daily dose of acetaminophen should not exceed 3000 mg.
The potential carcinogenicity of azacitidine was evaluated in mice and rats. Azacitidine induced tumors of the hematopoietic system in female mice at 2.2 mg/kg (6.6 mg/m2, approximately 8% the recommended human daily dose on a mg/m2 basis) administered IP three times per week for 52 weeks. An increased incidence of tumors in the lymphoreticular system, lung, mammary gland, and skin was seen in mice treated with azacitidine IP at 2 mg/kg (6 mg/m2, approximately 8% the recommended human daily dose on a mg/m2 basis) once a week for 50 weeks. A tumorigenicity study in rats dosed twice weekly at 15 or 60 mg/m2 (approximately 20%-80% the recommended human daily dose on a mg/m2 basis) revealed an increased incidence of testicular tumors compared with controls.  
The mutagenic and clastogenic potential of azacitidine was tested in in vitro bacterial systems Salmonella typhimurium strains TA100 and several strains of trpE8, Escherichia coli strains WP14 Pro, WP3103P, WP3104P, and CC103; in in vitro forward gene mutation assay in mouse lymphoma cells and human lymphoblast cells; and in an in vitro micronucleus assay in mouse L5178Y lymphoma cells and Syrian hamster embryo cells. Azacitidine was mutagenic in bacterial and mammalian cell systems. The clastogenic effect of azacitidine was shown by the induction of micronuclei in L5178Y mouse cells and Syrian hamster embryo cells.  
Administration of azacitidine to male mice at 9.9 mg/m2 (approximately 9% the recommended human daily dose on a mg/m2 basis) daily for 3 days prior to mating with untreated female mice resulted in decreased fertility and loss of offspring during subsequent embryonic and postnatal development. Treatment of male rats 3 times per week for 11 or 16 weeks at doses of 15 to 30 mg/m2 (approximately 20%-40%, the recommended human daily dose on a mg/m2 basis) resulted in decreased weight of the testes and epididymides, and decreased sperm counts accompanied by decreased pregnancy rates and increased loss of embryos in mated females. In a related study, male rats treated for 16 weeks at 24 mg/m2 resulted in an increase in abnormal embryos in mated females when examined on day 2 of gestation.
Our subjective worlds are built from those things in our internal and external environments that capture our attention. Environments can be ambiguous with respect to which objects are most important for our attention, and the characteristics of stimuli that allow them to dominate attention are thus of great interest. Self-relevant objects, such as internally generated experience (e.g. thought), may receive substantial attention, but research on this dimension has been hampered by the difficulty of measuring such objects experimentally. The proposed study seeks to make headway in this area using several behavioral (accuracy, response time, response pattern) measures, with the hypothesis that internally generated experience will vie for attention in a way reflected by behavior. Such research will extend previous work the investigators' lab has done studying stimulus parameters that influence attention, and as a whole may present a more complete picture of how objects and attention interact to shape our worlds.