anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Botulinum toxin is a neurotransmitter produced by clostridium Botulinum. It is the one of the most beneficial method for treating spasticity and providing functional improvement. By reducing the spasticity, the available muscle can be utilized to perform functional activities. Muscle volume decreases following the administration of Botulinum toxin to the neuromuscular junction. Strength training has positive impact on improving muscle volume. There are few studies are available regarding the exercise training following the administration of Botulinum toxin to the neuromuscular junction. But to the best of the investigators knowledge, there is no study available regarding the effectiveness of strength training on muscle volume and gross motor function following the administration of Botulinum toxin to the neuromuscular junction.2. To determine the effectiveness of strength training on muscle volume estimated by Ultrasound imaging following the administration of Botulinum toxin to hamstring and gastrocnemius is the objective of the study. The study protocol was approved by the institutional research advisory committee (RAC) and registered under the Universal Trial Number (UTN), U1111-1240-0890. The protocol will be registered under ClinicalTrials.gov, under World Health Organization International Clinical Trials Registry Platform and then the study will be submitted for the ethical approval by institutional ethics committee of Maharishi Markandeshwar Deemed to Be University, Mullana, and Haryana with unique reference number. The study will be executed in accordance with the principles of the Declaration of Helsinki (Revised, 2013) and National ethical guidelines for Biomedical and Health research involving human participants by Indian council for medical research (ICMR, 2017). The purpose of the study will be clearly explained to the patient with Head and neck cancer. Written informed consent form will be obtained from the recruited patients. Total of X CSDCP and CHCP will be screened and through convenience sampling method, 34 children will be selected based on the inclusion criteria for the cross-over trail design. Demographic data will be recorded for all the recruited children.

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Participants with Parkinson disease randomized to the virtual visit intervention will receive educational materials from the National Parkinson Foundation, complete a baseline assessment and virtual study assessment with a physician independent rater, and then receive four virtual care visits with a Parkinson disease specialist in their state. Specialists will provide recommendations for care to participants and their designated local health care provider. At 12 months, these individuals will again be assessed by the independent rater, who will be blind to treatment assignment.
PURPOSE: A composition containing bavachinin A for preventing and treating obesity or lipid metabolic disorders is provided to effectively suppress adipocyte differentiation. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity or lipid metabolic disorders contains bavachinin A as an active ingredient. The lipid metabolic disorder is selected among diabetes, hyperlipidemia, fatty liver, arteriosclerosis, hypertension, cardiovascular disease, and metabolic syndrome. Bavachinin A suppresses adipocyte differentiation. A health food for preventing obesity or lipid metabolic disorders contains bavachinin A as an active ingredient. [Reference numerals] (AA) Neutral lipid (absorbance); (BB) Normal; (CC) Control group; (DD) Bavachinin A
Prehypertension is a predisposing condition for morbidity in hypertension and cardiovascular diseases. This has been defined as a systolic pressure from 120 to 139 mmHg or a diastolic pressure of 80-89 mm hg. The prevalence of this condition estimated to be at least 2 times higher than hypertension and those who have prehypertension 4 times more likely to progress to hypertension than normotensive people. Although, hypertension is a multi-factorial disease, lifestyle is associated mainly to its development. According to information, lifestyle changes may prevent more than 70% of primary hypertension and health education is a key strategy to promote lifestyle modification. Health education via electronic pathways such as mobile text messaging or virtual communities may provide more availability and adherence than printed media. Regarding lower costs of such electronic resources and continuity of interventions through these ways, assessing their effectiveness compared to a printed material may help health educators to choose proper methods for improve their educational attempts. Therefore, the current study aims to compare different tools for health education about healthy lifestyle in people with prehypertension. For this, educational interventions with similar content among 3 groups of people will be conducted (i.e., first group via mobile text messaging, second group using virtual communities, and third group by brochures as a printed media). A control group also will be considered without any intervention. Several phases are considered in the study. In phase 1 using health centers located in Qazvin city, people would be invited to a free screening program of prehypertension. Then, an eligible sample will be divided in three groups using a random allocation process (each one including 100-150 people with prehypertension). The blood pressure and health promotion lifestyle profile II (HPLP II) will be measured before intervention. A standard educational content using approaches of lifestyle promotion defined in HPLP II would be available for intervention groups during a time period of 1 month concurrently. At final phase, one month after termination of intervention blood pressure as primary outcome and lifestyle changes along with self-efficacy for lifestyle modification as secondary outcomes will be measured. This study may suggest effective ways for health education which is applicable by health care professionals to promote health status among people at risk of hypertension.
The experimental group will be given min. 5 slices of bread baked with sourdough per day.
The invention discloses an oligosaccharide mixture comprising 5-70 wt% of at least one N-acetylated oligosaccharide, 5-90 wt% of at least one neutral oligosaccharide, 2-50 wt% of at least one sialylated oligosaccharide, and/or 5-70 wt% of at least one fucosylated oligosaccharide. The invention also discloses a food product, especially an infant formula, comprising said oligosaccharide mixture. The invention discloses an oligosaccharide mixture comprising 5-70 wt% of at least one N-acetylated oligosaccharide, 5-90 wt% of at least one neutral oligosaccharide, 2-50 wt% of at least one sialylated oligosaccharide, and/or 5-70 wt% of at least one fucosylated oligosaccharide. The invention also discloses a food product, especially an infant formula, comprising said oligosaccharide mixture. A water-dispersable polyurethane resin is obtained by reacting: at least one polycarbonate polyol; optionally, a polyester polyol which is different from the polycarbonate polyol; optionally, a low molecular weight compound containing two or more hydroxy and/or amino groups; optionally, a compound which is monofunctional in terms of reaction with NCO groups or which contains active hydrogen atoms differing in reactivity, these units being located in each case at the chain end of a polymer containing urethane groups; at least one compound containing at least two isocyanate-reactive groups and at least one group capable of forming anions; and a polyisocyanate component comprising â¥ 5 weight- % to â¤ 95 weight-% of hexamethylene diisocyanate and â¥ 5 weight- % to â¤ 95 weight- % of diisocyanatodicyclohexylmethane and/or isophorone diisocyanate, the total weight percentages amounting to â¤100 weight-%. The resultant polyurethane resin contains from 1.5% to 25.0% by weight of incorporated carbonate groups -O(C=O)O-.
PURPOSE: To compare rates of retinal nerve fiber layer change over time in healthy, eyes with nonprogressing glaucoma and eyes with progressing glaucoma using single wide-field (SWF) and optic nerve head (ONH) cube scan optical coherence tomography (OCT) images.
METHODS: Forty-five eyes of 25 healthy individuals and 263 eyes of 161 glaucoma patients from the Diagnostic Innovations in Glaucoma Study were included. All eyes underwent 24-2 visual field testing and OCT (Spectralis SD-OCT) ONH and macular imaging. SWF images (up to 43° × 28°) were created by stitching together ONH cube scans centered on the optic disc and macular cube scans centered on the fovea. Visual field progression was defined as guided progression analysis likely progression and/or a significant (P < 0.01) mean deviation slope of less than -1.0 dB/year. Mixed effects models were used to compare rates of change. Highly myopic eyes were included.
RESULTS: Thirty glaucomatous eyes were classified as progressing. In eyes with glaucoma, mean global rate of change was -1.22 µm/year (P < 0.001) using SWF images and -0.83 µm/year (P = 0.003) using ONH cube scans. Rate of change was significantly greater in eyes with progressing glaucoma compared with eyes with nonprogressing glaucoma (-1.51 µm/year vs. -1.24 µm/year; P = 0.002) using SWF images and was similar using ONH cube scans (P = 0.27).
CONCLUSIONS: In this cohort that includes eyes with and without high axial myopia, the mean rate of retinal nerve fiber layer thinning measured using SWF images was faster in eyes with progressing glaucoma than in eyes with nonprogressing glaucoma. Wide-field OCT images including the ONH and macula can be effective for monitoring glaucomatous progression in patients with and without high myopia.
PURPOSE:To prevent leak to other persons and an alteration by sectioning medical diagnosis information into the information to restrict an operator and the information not to restrict him, deciding whether the operator is the specified person or not and permitting the write and read of the information according to the decision result. CONSTITUTION:When the operator requests, for example, the write, a write/read selecting key 1600 is pushed, the write is instructed, and thereafter, an item number to execute the write is inputted from a ten key input part 1602. For the section read from a recording medium 3 for restricting an operator, whether the write of the item is permitted or not is judged, and when it is permitted, the inputted item number and item are displayed on a display part 12. The operator input a write numeric value from the ten key input part 1602. A device 10 displays the numeric value inputted from the ten key input part 1602 on the display part 12, the operator confirms that the numeric value to be inputted is correct by the display, and thereafter, the operator pushes a write instructing key 1604. When the device 10 confirms that the above- mentioned write instructing key 1604 is pushed, the device 10 writes the inputted information to a recording medium 20 for storing medical diagnosis information by a writing/reading part 14.
BACKGROUND: Numerous studies have demonstrated the influence of gut microbiota on the development of obesity. In this study, we utilized Mendelian randomization (MR) analysis to investigate the gut microbiota characteristics among different types of obese patients, aiming to elucidate the underlying mechanisms and provide novel insights for obesity treatment.
METHODS: Two-sample multivariable Mendelian randomization (MR) analysis was employed to assess causal relationships between gut microbiota and various obesity subtypes. Gut microbiota data were obtained from the international consortium MiBioGen, and data on obese individuals were sourced from the Finnish National Biobank FinnGen. Eligible single-nucleotide polymorphisms (SNPs) were selected as instrumental variables. Various analytical methods, including inverse variance weighted (IVW), MR-Egger regression, weighted median, MR-RAPS, and Lasso regression, were applied. Sensitivity analyses for quality control included MR-Egger intercept tests, Cochran's Q tests, and leave-one-out analyses and others.
RESULTS: Mendelian randomization studies revealed distinct gut microbiota profiles among European populations with different obesity subtypes. Following multivariable MR analysis, we found that Ruminococcaceae UCG010 [Odds Ratio (OR): 0.842, 95% confidence interval (CI): 0.766-0.926, Adjusted P value: 0.028] independently reduced the risk of obesity induced by excessive calorie intake, while Butyricimonas [OR: 4.252, 95% CI: 2.177-8.307, Adjusted P value: 0.002] independently increased the risk of medication-induced obesity. For localized adiposity, Pasteurellaceae [OR: 0.213, 95% CI: 0.115-0.395, Adjusted P value: <0.001] acted as a protective factor. In the case of extreme obesity with alveolar hypoventilation, lactobacillus [OR: 0.724, 95% CI: 0.609-0.860, Adjusted P value: 0.035] reduced the risk of its occurrence. Additionally, six gut microbiota may have potential roles in the onset of different types of obesity. Specifically, the Ruminococcus torques group may increase the risk of its occurrence. Desulfovibrio and Catenabacterium may serve as protective factors in the onset of Drug-induced obesity. Oxalobacteraceae, Actinomycetaceae, and Ruminiclostridium 9, on the other hand, could potentially increase the risk of Drug-induced obesity. No evidence of heterogeneity or horizontal pleiotropy among SNPs was found in the above studies (all P values for Q test and MR-Egger intercept > 0.05).
CONCLUSION: Gut microbiota abundance is causally related to obesity, with distinct gut microbiota profiles observed among different obesity subtypes. Four bacterial species, including Ruminococcaceae UCG010, Butyricimonas, Pasteurellaceae and lactobacillus independently influence the development of various types of obesity. Probiotic and prebiotic supplementation may represent a novel approach in future obesity management.
PURPOSE: A composition for preventing or treating vascular diseases containing Gleditsia sinensis Lam. extract is provided to suppress cell cycle at G2/M phase and cell migration and induce apoptosis. CONSTITUTION: A composition for suppressing smooth muscle cell proliferation contains Gleditsia sinensis Lam. as an active ingredient. A composition for treating or preventing hyperproliferative vascular disorders contains Gleditsia sinensis Lam. extract as an active ingredient. The extract is isolated using water, hydrous or anhydrous low alcohol of 1-4 carbon atoms, mixture solvent of low alcohol and water, acetone, ethyl acetate, chloroform, 1,3-butyleneglycol, hexane, diethylether, or butylacetate. The composition is a pharmaceutical composition or food composition.
All adult patients with kidney failure referred to a department of renal medicine at one of the four hospitals from the 1st of October 2016 to the 31st of May 2018 were offered the intervention and invited to participate in the study. The inclusion criterion was an estimated glomerular filtration rate below 20 ml/min and based on a clinical judgement made by the contact doctor and/or the contact nurse about the decline in the Estimated glomerular filtration rate to continue. Exclusion criteria were patients who had decided on conservative management, patients with a living donor and a set date for transplantation and patients not able to participate in the intervention due to cognitive impairment. The use of an interpreter was not an exclusion criterion.
A rehabilitation PAC team will care for patients in the hospital within 3 weeks after acute hospitalization. The patient will have 1 to 2 session(s) of PT or OT on weekdays, and a daily physician visit and nurse care.
The invention discloses a TCM (traditional Chinese medicine) preparation for preventing and treating cardiovascular and cerebrovascular diseases. A monarch drug is made from 350 to 450 parts of bee pollen, 270 to 370 parts of mulberry, 300 to 400 parts of manyflower solomonseal rhizome, and 350 to 450 parts of Cordyceps militaris. A ministerial drug is made from 300 to 400 parts of kudzuvine root, 250 to 350 parts of peach kernel and 300 to 400 parts of hawthorn. An Adjuvant drug is made from 200 to 300 parts of seed of wild jujube, 250 to 350 parts of longan pulp, 250 to 350 parts of wolfberry fruit, and 50 to 150 parts of cassia bark. An envoy drug is made from 200 to 300 parts of honeysuckle flower, 220 to 320 parts of cassia seed, 250 to 350 parts of Indian bread, and 210 to 210 parts of chrysanthemum. The TCM preparation with natural non-toxic herbal medicines and with no mineral drugs has mild and precise efficacy, is non-toxic and harmless, is friendly to the boy in long-term consumption, is especially suitable for patients with cardiovascular and cerebrovascular diseases, and allows on the whole the patients to get better or recover in a short time and reach the clinical rehabilitation level.
PURPOSE:To make it possible to measure active osteocalcine specifically and to make it be useful for diagnosis of a bone disease by using hydroxyapatite and a substance being combinable with the osteocalcine or a fragment thereof, as measuring reagents. CONSTITUTION:Hydroxyapatite and a substance being combinable with osteocalcine or a fragment thereof are used as measuring reagents. The kind of the hydroxyapatite is not limited particularly and the one used for separation and production of protein, DNA, etc., can be used. As for the shape, too, it may be particle-shaped, granular, tubular, flat-plate-shaped or in other shapes. As to the substance being combinable with the osteocalcine, an anti-osteocalcine antibody or collagen can be mentioned, for instance. As for the anti-osteocalcine antibody, either an antiserum or a monoclonal antibody may be used and it is not limited by the class, affinity, specificity, etc., of an antibody. As to the antibody to be used, an active fragment of the antibody is preferable for the purpose of preventing non-specific adsorption.
Control Group (n=54) The researcher did the explanation of the questionnaire sheet to the pediatric student nurses to assess their awareness and attitude toward hemoglobinopathies. The researcher observed the pediatric student nurses 'practice during applying blood transfusion, subcutaneous medication administration, and oral medication administration using the observational checklist at faculty laboratory.
The invention relates to a preparation method and application of tetrandrine solid lipid nanoparticles. The tetrandrine solid lipid nanoparticles are composed of tetrandrine, soybean lecithin, soybean oil and water. In the preparation process, a solvent method is firstly utilized to form the tetrandrine phospholipid compound, and then a film dispersion and ultrasonic freeze-drying method is adopted to prepare the tetrandrine solid lipid nanoparticles. The tetrandrine solid lipid nanoparticle is simple and convenient in preparation method, and high in encapsulation efficiency and drug loading capacity. The prepared tetrandrine solid lipid nanoparticles are freeze-dried powder, and can effectively improve the stability and transportation convenience of the preparation. The tetrandrine solid lipid nanoparticles prepared by the invention can be used for treating tissue fibrosis and pneumoconiosis diseases by oral administration, injection administration, inhalation administration and the like.
Participants will receive three texts each week asking a question about their workout. Regardless of whether or not they respond to the texts, participants receive 500 bonus points for their first three workouts during the week. These bonus points are on top of points participants receive for each workout (200 points per workout).
OBJECTIVE: This systematic review and meta-analysis aimed to estimate the prevalence of voice disorders and related factors in university professors.
METHODS: In this systematic review, Medline, Scopus, Embase, Cochrane Library, Eric, ProQuest, Magiran, Scientific Information Database and IranDoc databases were searched. The search was limited to January 1990 and May 2020. The inclusion criteria were reports of the prevalence of voice disorders in university professors and original studies in English and Persian languages. The exclusion criteria were studies assessing voice disorders in school or music teachers; the full-text not available; and case studies, conference papers, and review studies. All eligible studies were selected and critically appraised using the Joanna Briggs Institute checklist. Finally, a meta-analysis was performed using STATA 16.0 statistical software.
RESULTS: The preliminary search yielded 1251 articles and 18 of which met the eligibility criteria. The overall prevalence of voice disorders in university professors was 41% (Pooled prevalence: 0.41, 95% CI: 0.34-0.49, P-value < 0.001). Country-based analysis showed that the highest prevalence of voice disorders among university professors was in Iran 69% (Pooled prevalence: 0.69, 95% CI: 0.62-0.76) and the lowest was in China 20% (Pooled prevalence: 0.20, CI: 0.14-0.27). Among 4037 university professors, caffeine consumption was the most frequent related factor (87%) and dry throat was the most frequent symptom (46%).
CONCLUSIONS: The present study yielded about 41% of the professors had voice disorders. Among the influential habits, caffeine consumption and among the symptoms, dry throat were very common in university professors. Due to the cross-sectional nature of our studies, we were not able to perform further analyses on the risk factors for voice disorders. Therefore, more longitudinal surveys are needed for reaching a more reliable and deep view into the development of voice disorders.
912,326. Coffee and like extracts. KOELLE, G., and KOELLE, S. Dec. 28, 1959, No. 43964/59. Class 129. Coffee or other material is extracted by circulating the extracting liquid under reduced pressure in a closed circuit, withdrawing a small amount of the liquid from the circuit and using it for cold extraction of the material under reduced pressure and feeding the product back into the circuit; a second extraction with the same or a different liquid, and preferably at a more reduced pressure, can be carried out. The vacuum conduit 12 draws cold water from a container 2 through a steam-heated section to a collector 6 whence the liquid can return to the container. Vapour is withdrawn from the collector through a pipe 9 and past a cooling coil 10 where it condenses and falls on the material to be extracted in the vessel 13, where it collects until it siphons over the tube 16 back to the container 2. The material can be further extracted with the same or a different liquid and under more reduced pressure. The extract is fed to a container 20 containing a stirring mechanism, and other materials such as fructose can be added. From the container 20, the extract passes to a drier 23 and storage receptacle 24. The extracted material in the vessel 13 is dried in a drier 25 and ground in a mill 27, after which it can be added to the extract in the container 20. A simpler form of apparatus is also described.