anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a traumatic injury safflower medicine capsule and a preparation method thereof. The traumatic injury safflower medicine capsule comprises capsule shell and content in the capsule. The content is prepared from following raw materials by weight: 101.4 parts of pseudo-ginseng, 23.6 parts of safflower, 23.6 parts of Chinese angelica, 23.6 parts of ligusticum wallichii, 23.6 parts of dahurian angelica root, 23.6 parts of ground beetle and 30 parts of starch. The capsule medicine is good in stability, and is mainly prepared from the pseudo-ginseng, the safflower, the Chinese angelica, the ligusticum wallichii, the dahurian angelica root and the ground beetle. The capsule medicine has functions of simultaneously treating principal and subordinate symptoms, invigorating blood circulation and relieving pain, and removing stasis and producing new blood, and has good curative effects for traumatic injury, blood stasis, rheumatism, numbness, and swell and pain for muscles and bones. In addition, the preparation method is simple and the production cost is low.
Ecological momentary assessment (EMA) allows for the collection of participant-reported outcomes (PROs), including pain, in the normal environment at high resolution and with reduced recall bias. Ecological momentary assessment is an important component in studies of pain, providing detailed information about the frequency, intensity, and degree of interference of individuals' pain. However, there is no universally agreed on standard for summarizing pain measures from repeated PRO assessment using EMA into a single, clinically meaningful measure of pain. Here, we quantify the accuracy of summaries (eg, mean and median) of pain outcomes obtained from EMA and the effect of thresholding these summaries to obtain binary clinical end points of chronic pain status (yes/no). Data applications and simulations indicate that binarizing empirical estimators (eg, sample mean, random intercept linear mixed model) can perform well. However, linear mixed-effect modeling estimators that account for the nonlinear relationship between average and variability of pain scores perform better for quantifying the true average pain and reduce estimation error by up to 50%, with larger improvements for individuals with more variable pain scores. We also show that binarizing pain scores (eg, <3 and ≥3) can lead to a substantial loss of statistical power (40%-50%). Thus, when examining pain outcomes using EMA, the use of linear mixed models using the entire scale (0-10) is superior to splitting the outcomes into 2 groups (<3 and ≥3) providing greater statistical power and sensitivity.
<P>PROBLEM TO BE SOLVED: To determine the optimum operational condition of a passive training device by means of a computer simulation and a myoelectric potential measurement in a short time.  <P>SOLUTION: A simulator 2 seeks muscle activities and a power between joints in accordance with an operational condition to move a support stand of a passive training device 1 by means of a computer simulation. A condition focusing unit 6 selects a plurality of desirable candidate conditions from the muscle activities and power of joints sought through a simulator 2 in accordance with various operational conditions. An operation simulation device 3 includes the support stand achieving any movement of the support stand of the passive training device 1, and moves the support stand in accordance with the candidate conditions sought through the condition focusing unit 6. A myoelectric potential measurement device 4 measures a myoelectric potential of an examinee supported with a support stand of the operation simulation device 3. An evaluation device 5 selects an operational condition corresponding to a large muscle activity amount from a measured result of the myoelectric potential of the examinee and determines the condition as an operational condition of a passive training device 1.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Each participant completes 6 baseline sessions and 30 conditioning sessions. In each of the 30 conditioning sessions, while the participant is standing nerves in the lower leg and ankle are stimulated to activate the reflex. The participant attempts to change the reflex activity based on visual feedback. In this way the cutaneous reflex (skin reflex) will be changed to decrease neuropathic pain resulting from spinal cord injury.
The number of children in the United States who are overweight or obese has increased steadily over the past several decades. Latino children are at particular risk of becoming overweight or obese. Children who are overweight or obese have an increased risk of high blood pressure, high cholesterol, heart disease, and diabetes. Parental behaviors are thought to be important influences on children's obesity, but previous studies have only examined a narrow range of parental behaviors, and few studies have specifically focused on Latino children. There is an urgent need for further research that examines the ways in which parental eating habits and behaviors affect the rising obesity rates among Latino children. This study will focus on Mexican Americans, which is the largest Latino group in the United States. The purpose of this study is to examine whether parental and extended family members' dietary-related behaviors predict children's dietary intake and weight gain. The effects of socioeconomic status and cultural factors on parental behaviors will also be examined.

This study will enroll Mexican-American children and their parents. All study visits will occur at the participant's home. At a baseline visit, study staff will conduct a 1-hour interview with children and their parents to collect information on their thoughts about food, family eating habits, and how family members talk about food; children will also be asked about their physical development and physical activity level. Both parents and children will have their height, weight, waist, and hip circumference measured. Children will then wear an activity monitor for 3 days in the week following the baseline visit to measure physical activity levels. Two additional study visits will occur over the following 3 weeks. At the second visit, study staff will conduct 20-minute interviews with parents and children about their eating habits. At the third visit, study staff will videotape the child's evening meal, and additional interviews will occur. Follow-up visits will occur at Years 1 and 2. At both follow-up visits, repeat baseline interviews will occur, and children will wear the activity monitor for 3 days.
Modafinil will be administered at baseline with a single dose of 100 mg/day QAM increased at week 1 to a single dose 200mg/day QAM. Patients will take drug upon waking with no adjustment in sleep schedule. Dosing will be flexible based on side effects with a maximum dose of 200 mg/day. Subjects will be discontinued if 100mg/day is not tolerated.
A man in his 30s presented to the emergency department with a history of injury to the face with a crowbar. He was discharged from the department, in the absence of any facial bone fractures and given normal examination findings, except for a puncture wound on the mentum. The patient then re-presented within 24 hours with extensive cervical emphysema extending into the mediastinal cavity.He was referred to ear, nose and throat team for further management. CT scan of the chest and neck showed extensive surgical emphysema and a pneumomediastinum. The patient was managed conservatively and recovered well with no significant sequelae.Even in the absence of facial bone fractures, it is imperative to understand the force of impact which should prompt a consideration of imaging of the chest. Appropriate advice regarding avoidance of Valsalva manoeuvres will help prevent extensive propagation of air through the fascial planes that can result in a pneumomediastinum.
This is an exploratory study in a primary care setting with community pharmacists recruiting patients who are newly prescribed a PPI for a short-term treatment (30 days). There is no control group and no randomization. After informed consent and installing the app on their personal smartphones, patients will answer three questions from the app once daily. The questions address medication intake (yes/no), symptom course (better, worse, identical, no symptoms) and well-being (satisfactory/needs improvement). Worsening of symptoms will trigger an alarm (via email) at the pharmacy. The pharmacist will call the patients and use information from adherence and well-being to consolidate a supporting counseling.

Feasibility and a frequency estimation of the interventions will be the focus of the study in view of a larger implementation study with community pharmacies. Further implementation outcomes will be assessed through interviews and surveys (satisfaction, interprofessional work).
Objective. To assess the effects of inspiratory muscle training (IMT) on lung function, inspiratory muscle strength and athletic performance in soccer players.

Method. Participants will be randomized into two groups: experimental and sham . The two groups will perform a protocol of 8 weeks of training (6 days / week) with the PowerBreathe device. The EG will use progressive resistance loads up to 80% of the MIP, while the SG will use the device with a minimum load (20% PImax) during the 8 weeks. All participants will have the following tests before and after the intervention and 3 months after the end of the program: spirometry (FVC, FEV1), PImax, biophotogrammetry, and fit 30/15 test. For the statistical analysis, a 2-factor variance analysis will be performed for repeated measures and Pearson's correlations. The statistical significance will be set with a value of p \<0.05. The effect size will be calculated using the partial eta-square.
PURPOSE OF THE REVIEW: The use of bioelectrical impedance analysis (BIA) for monitoring body composition during the ketogenic diet has experienced a rapid surge. This scoping review aimed to assess the validity of procedures applying BIA in the ketogenic diet and to suggest best practices for optimizing its utilization.
RECENT FINDINGS: We conducted a systematic scoping review of peer-reviewed literature involving BIA for assessing body composition in individuals adhering to a ketogenic diet. Searches of international databases yielded 1609 unique records, 72 of which met the inclusion criteria and were reviewed. Thirty-five studies used foot-to-hand technology, 34 used standing position technology, while 3 did not declare the technology used. Raw bioelectrical parameters were reported in 21 studies. A total of 196 body mass components were estimated, but predictive equations were reported in only four cases. Most research on BIA during ketogenic diets did not report the equations used for predicting body composition, making it impossible to assess the validity of BIA outputs. Furthermore, the exceedingly low percentage of studies reporting and analyzing raw data makes it challenging to replicate methodologies in future studies, highlighting that BIA is not being utilized to its full potential. There is a need for more precise technology and device characteristics descriptions, full report of raw bioelectrical data, and predictive equations utilized. Moreover, evaluating raw data through vectorial analysis is strongly recommended. Eventually, we suggest best practices to enhance BIA outcomes during ketogenic diets.
Prior research has identified associations between immune cells and aplastic anaemia (AA); however, the causal relationships between them have not been conclusively established. A two-sample Mendelian randomisation analysis was conducted to investigate the causal link between 731 immune cell signatures and AA risk using publicly available genetic data. Four types of immune signatures, including relative cell, absolute cell (AC), median fluorescence intensities and morphological parameters, were considered sensitivity analyses were also performed to verify the robustness of the results and assess potential issues such as heterogeneity and horizontal pleiotropy. Following multiple test adjustments using the False Discovery Rate (FDR) method, no statistically significant impact of any immunophenotype on AA was observed. However, twelve immunophenotypes exhibited a significant correlation with AA without FDR correction (p of IVW < 0.01), of which eight were harmful to AA: CD127- CD8br %T cell (Treg panel), CD25 on IgD + CD38dim (B cell panel), CD38 on naive-mature B cell (B cell panel), CD39 + resting Treg % CD4 Treg (Treg panel), CD39 + secreting Treg AC (Treg panel), CD8 on CD28 + CD45RA- CD8br (Treg panel), HLA DR + NK AC (TBNK panel), Naive DN (CD4-CD8-) AC (Maturation stages of T cell panel); and four were protective to AA: CD86 on CD62L + myeloid DC (cDC panel), DC AC (cDC panel), DN (CD4-CD8-) NKT %T cell (TBNK panel), and TD CD4 + AC (Maturation stages of T cell panel). The results of this study demonstrate a close link between immune cells and AA by genetic means, thereby improving the current understanding of the interaction between immune cells and AA risk and providing guidance for future clinical research.
Stabilisation of pollen extracts contng. reducing sugars (C5-C6) and amino acids produced by hydrolysis of aqueous pollen extracts, characterised by freeze-drying the hydrolysed extract. The product is used in daily doses of 100-800 mg. in tonics, antiinflammatory drugs etc. or by local application e.g. as ointments contng. 3% of stable extract. The glutamic acid equivalent of a normal extract fell from about 7.6 to 3.1 at room temp. and 1.9 at 37 degrees C. after 6 months. There was no significant change in the value of treated extracts similarly stored.
PURPOSE: A method for supplying an integrated medical service and a device thereof are provided to supply medical data to a user automatically by receiving necessary data from a medical system as a newborn infant total management system, a PACS(Picture Archiving and Communication System), an OCS(Order Communication System), etc. when a user such as a doctor requests data with respect to a medical treatment or examination. CONSTITUTION: Inherent data stored in a system are requested to at least one system out of a newborn infant total management system, a PACS, an OCS or data are inputted to the system using a predetermined input unit(100). The data request or the inputted data are transmitted to a corresponding system(110). If a system received the transmitted data request transmits a message for displaying a normal transmission of data corresponded to the request and inputted data(120), the transmitted data or message is received and a data format of the data or message is checked(130). The format of the transmitted data or message is converted in accordance with the data format checked in the above stage and output to a user(140).
OBJECTIVES: I. To determine if Chronos (beta-tricalcium phosphate bone graft) will form a posterolateral fusion mass in patients undergoing fusion surgery for spine cancer within 12 months. II. To evaluate quality of life following the use of ChronOS as measured by (a) pain (or lack of pain) associated with pseudoarthrosis and (b) the need for additional treatment for instability as a result of hardware failure. OUTLINE: Patients undergo placement of beta-tricalcium phosphate bone graft strips posterolaterally during surgery. After completion of study treatment, patients are followed up at 1 month and then every 3 months for 1 year.
There is no data regarding success rates and incidence of carotid punctures during central venous cannulation (CVC) in pregnant patients. We hypothesize that because of the anatomical and physiological changes associated with pregnancy, these patients are at higher risk of procedure failure and carotid puncture than the general population. The purpose of our study is to determine the success rate and incidence of carotid punctures using an ultrasound-simulated procedure in pregnant and non-pregnant patients.

Pregnant patients and adult female volunteers (controls) were recruited. Subjects were placed supine with wedge under the right hip, and head turned 35 degrees to the left. Two different approaches for CVC, the central landmark and the palpatory approach were used. The ease of identification of the landmarks was noted. CVC was simulated using an ultrasound probe, on pre-marked points. Ultrasound images were obtained, within the same parasagittal plane, directed 30 degrees caudad, in a manner simulating how a syringe and needle would be placed for central venous cannulation. The investigator placing the probe was blinded to the image being generated. The vertical cursor of the ultrasound, which serves to delineate the path of a needle, was placed in the image. If the cursor intersects the vein, the attempt is considered successful. If the first attempt is not successful, the investigator placing the probe was asked to redirect the probe to the second and if necessary to the third marked point. This was done for each approach. If the cursor intersects the carotid artery, the attempt is considered an accident and no further attempts were made. In addition to determining the success rate and the incidence of carotid punctures, the relative position of vein and artery was studied in each patient. For each approach, the best image was recorded, and three experienced anesthesiologist scored the images for vein and artery degree of overlapping.
This is a transdermal device with diethylcarbamazine (DEC) applied directly on the skin. The reading will be done 24 hours after.
Adenocarcinoma of the endometrium is the most prevalent invasive tumor of female genital tract. Endometrial carcinoma is divided to 2 different types as regards to genitical and phenotypical features, type I endometrial carcinoma represents more than three quarters of all cases. Type I is inevitably preceded by hyperplastic changes in the endometrium. However, the malignant potential of endometrial hyperplasia to carcinoma is markedly variable and subjected to interobserver variations. Determine of novel biological markers for detection of precancerous endometrial hyperplasia that may proceed to endometrial adenocarcinoma is a must. PTEN is a tumor suppressor gene. it inhibits cell mitosis and migration. PTEN induce the damaged cells to pass in apoptosis. Low levels of PTEN expression noted in many human malignancies as melanoma, mammary and ovarian carcinomas.

The aim of this study is to evaluate the expression of PTEN (by immunohistochemistry) in different endometrial biological conditions as endometrial hyperplasia and primary endometrial adenocarcinoma specimens, and correlate that expression to PTEN expression in physiological endometrial specimens.
OBJECTIVE: Microglial polarization plays a critical role in neuroinflammation and may be a potential therapeutic target for ischemic stroke. This study was to explore the role and underlying molecular mechanism of Circular RNA PTP4A2 (circPTP4A2) in microglial polarization after ischemic stroke.
METHODS: C57BL/6J mice underwent transient middle cerebral artery occlusion (tMCAO), while primary mouse microglia and BV2 microglial cells experienced oxygen glucose deprivation/reperfusion (OGD/R) to mimic ischemic conditions. CircPTP4A2 shRNA lentivirus and Colivelin were used to knock down circPTP4A2 and upregulate signal transducer and activator of transcription 3 (STAT3) phosphorylation, respectively. Microglial polarization was assessed using immunofluorescence staining and Western blot. RNA pull-down and RNA binding protein immunoprecipitation (RIP) were applied to detect the binding between circPTP4A2 and STAT3.
RESULTS: The levels of circPTP4A2 were significantly increased in plasma and peri-infarct cortex in tMCAO mice. CircPTP4A2 knockdown reduced infarct volume, increased cortical cerebral blood flow (CBF), and attenuated neurological deficits. It also decreased pro-inflammatory factors levels in peri-infarct cortex and plasma, and increased anti-inflammatory factors concentrations 24 h post-stroke. In addition, circPTP4A2 knockdown suppressed M1 microglial polarization and promoted M2 microglial polarization in both tMCAO mice and OGD/R-induced BV2 microglial cells. Moreover, circPTP4A2 knockdown inhibited the phosphorylation of STAT3 induced by oxygen-glucose deprivation. In contrast, increased phosphorylation of STAT3 partly counteracted the effects of circPTP4A2 knockdown. RNA pull-down and RIP assays further certified the binding between circPTP4A2 and STAT3.
CONCLUSION: These results revealed regulatory mechanisms of circPTP4A2 that stimulated neuroinflammation by driving STAT3-dependent microglial polarization in ischemic brain injury. CircPTP4A2 knockdown reduced cerebral ischemic injury and promoted microglial M2 polarization, which could be a novel therapeutic target for ischemic stroke.
Patients placed in the catheterized group will have an indwelling catheter placed after anesthetic has been administered. It would be removed at 12 hours post Cesarean section.
In general, β-blockers may mask some of the manifestations of hypoglycemia, particularly tachycardia. Nonselective β-blockers may potentiate insulin-induced hypoglycemia and delay recovery of serum glucose levels. Patients subject to spontaneous hypoglycemia, or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned about these possibilities.

In patients with heart failure and diabetes, carvedilol therapy may lead to worsening hyperglycemia, which responds to intensification of hypoglycemic therapy. It is recommended that blood glucose be monitored when carvedilol dosing is initiated, adjusted, or discontinued. Trials designed to examine the effects of carvedilol on glycemic control in patients with diabetes and heart failure have not been conducted.

In a trial designed to examine the effects of carvedilol on glycemic control in a population with mild-to-moderate hypertension and well-controlled type 2 diabetes mellitus, carvedilol had no adverse effect on glycemic control, based on HbA1c measurements [ see Clinical Studies (14.4)].
The invention belongs to the technical field of medical care, and particularly relates to a drug pillow for treatment of a woman climacteric syndrome. The drug pillow for treatment of the woman climacteric syndrome comprises a pillow body, and a conical protrusion corresponding to the acupuncture point of the brain is arranged on the upper surface of the pillow body. A drug bag is arranged in the pillow body, and the drug bag extends to the conical protrusion. The drug bag is filled with liquid drug, and the liquid drug is composed of, by weight, Chinese yam, roots of rehmannia, radix aconiti praeparata, glossy privet fruits, radix paeoniae alba, fleece-flower roots, radix bupleuri, Poria cocos, Concha Margaritiferallsta, tuber fleeceflower stem and amber. An electric heating wire is arranged in the drug bag, and a temperature control switch is arranged on the outer side of the pillow body. The liquid drug in the drug pillow is mild in drug property, free of side effects and can not hurt the body of a woman, the woman climacteric syndrome can be treated in the sleeping process of a patient, the patient does not need to consume time and energy, and the woman climacteric syndrome can be cured once for all when the drug pillow is used in a long term.