anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a well-established noninvasive procedure for the evaluation and risk stratification of patients with coronary artery disease (CAD). However, it has been recognized that in certain patients SPECT MPI is unable to detect the presence of CAD or underestimates its extent. The fact that moderate to severe perfusion defects are noted in less than half of the patients with significant left main disease has stimulated studies to improve the diagnostic accuracy of SPECT MPI. These studies have analyzed post-stress parameters such as left ventricular (LV) ejection fraction (EF), wall motion abnormalities and transient LV dilation. However, these parameters were derived from data acquired using conventional Anger cameras as long as 60 minutes after stress tracer injection. Such delayed assessment may miss early ischemic stunning as a result of its rapid transient changes. However, with highly sensitive detectors and short lived tracers, the ability of PET MPI to measure EF during peak of stress has been reported. Similarly, the novel cadmium-zinc-telluride (CZT) SPECT cameras with solid state cardiac-focused detectors are significantly more sensitive than the conventional Anger scintillation cameras giving to SPECT the "PET-like" ability to image rapidly right after the stress test. The aim of this study is to evaluate early post-stress EF change (∆EF) and its relation to the severity of myocardial ischemia and angiographic coronary disease using CZT-SPECT MPI.
PURPOSE: In a certain proportion of dichorionic twin pregnancies, the two placentas are fused. The clinical significance of this finding remains unclear. Our objective was to compare outcomes of dichorionic twin pregnancies with fused versus separate placentas as determined on first-trimester ultrasound.
METHODS: Retrospective study of patients with dichorionic twins followed at a tertiary center between 2014 and 2022. The co-primary outcomes were fetal growth restriction and preeclampsia. Associations between fused placentas and the study outcomes were estimated using multivariable Poisson regression and were reported as adjusted relative risk (aRR) with a 95%-confidence interval (CI).
RESULTS: Of the 328 eligible patients, 175 (53.4%) and 153 (46.6%) had fused and separate placentas, respectively. Compared with pregnancies with separate placentas, patients with fused placentas had a lower risk of preeclampsia [aRR 0.48 (95%-CI 0.24-0.97)] but a higher risk of fetal growth restriction [aRR 1.23 (95%-CI 1.02-1.48)] and admission to the neonatal intensive care unit [aRR 1.31 (95%-CI 1.01-1.71)]. In addition, pregnancies with fused placentas were more likely to have a total placental weight below the 10th percentile than those with separate placentas [aRR 1.93 (95%-CI 1.16-3.21)].
DISCUSSION: Dichorionic twin pregnancies with fused placentas have a lower risk of preeclampsia but are more likely to be complicated by fetal growth restriction, observations that may be attributed to the lower total placentas mass in pregnancies with fused compared with separate placentas. Fused placentas can be used as a potential biomarker for the prediction of pregnancy complications in dichorionic twin pregnancies.
BACKGROUND: Although many health problems, including sleep disorders, have been associated with video gaming, further studies are required to establish the validity of these connections. This study aimed to determine the prevalence of gaming addiction among medical students and its association with poor sleep quality, which may be reflected in academic performance.
METHOD: A cross-sectional survey was conducted between January and June 2023 among medical students at the institution under study. An online survey was conducted and was divided into three sections. The first section included the demographic data, the second section included the 7-item Gaming Addiction Scale (GAS), and the third section included the Pittsburgh Sleep Quality Index. Using the GAS, and based on the total score, gamers were classified as addicted, problematic, engaged, or normal. Hence, abnormal gamers include engaged, problematic, and addicted gamers.
RESULT: There were 356 participants with a mean age of 22.5 -/+ 1.8 years, and 75.3% were males. The data showed that 38.8% of the study population were abnormal gamers: 40 (11.2%) engaged gamers, 81 (22.8%) problematic gamers, and 17 (4.8%) addicted gamers. Furthermore, abnormal gaming was linked to poor sleep quality when comparing abnormal gamers with normal gamers (92% vs. 80.3%, p = 0.002). Further comparison between the types of abnormal gamers revealed that addicted gamers were found to rely on sleep medication to help them sleep at night and took longer time to fall asleep (p = 0.050 and p = 0.045, respectively).
CONCLUSION: Abnormal gamers are common among medical students and strongly associated with poor sleep quality compared to normal gamers.
<P>PROBLEM TO BE SOLVED: To provide a compression-molded solid powder cosmetic which contains an elastic powder, has a good impact resistance without impairing sense of use or usability, and has reduced solid catalyst activity.  <P>SOLUTION: The compression-molded solid powder cosmetic comprises an elastic powder, a liquid oil, and a pulverized polyethylene terephthalate powder having an average particle diameter of 1-30 μm. The compounded amount of the elastic powder is 0.5-7 mass%; that of the liquid oil is 2-15 mass%; and that of the pulverized polyethylene terephthalate powder is 20-75 mass%. Preferably, the elastic powder has a hardness by JIS K 6301 spring-type hardness test of 30-50 and an average particle diameter of 3-35 μm. Preferably, a solid oil powder in an amount of 0.05-1 mass% is blended into the compression-molded solid powder cosmetic. Preferably, the solid oil powder has an average particle diameter of 0.05-20 μm and a melting point of 85-125°C. A metal oxide powder may be blended into the compression-molded solid powder cosmetic, wherein the metal oxide is preferably a surface-treated metal oxide powder.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Cognitive symptoms and sleep disturbance (SD) are common non-mood-related symptoms of major depressive disorder (MDD). In clinical practice, both cognitive symptoms and SD are related to MDD progression. However, there are only a few studies investigating the connection between cognitive symptoms and SD in patients with MDD, and only preliminary evidence suggests a significant association between cognitive symptoms and SD in patients with mood disorders. This study investigates the relationship between cognitive symptoms and sleep quality in patients with major depressive disorder. Patients (n = 20) with MDD were enrolled; their mean Hamilton Depression Scale-17 score was 21.95 (±2.76). Gold standard polysomnography (PSG) was used to assess sleep quality, and the validated THINC-integrated tool (the cognitive screening tool) was used to evaluate cognitive function in MDD patients. Overall, the results showed significant correlations between the cognitive screening tool's total score and sleep latency, wake-after-sleep onset, and sleep efficiency. These findings indicate that cognitive symptoms are associated with poor sleep quality among patients with MDD.
The invention relates to infantile talcum powder. The infantile talcum powder is prepared from a main material A, an auxiliary material B and an auxiliary material C in parts by mass. The main material A is prepared from 15-20 parts of corn starch, 60-65 parts of masson pine pollen and 15-20 parts of zinc oxide through stirring and being sieved by an 800-mesh sieve. The auxiliary material B is prepared from 0.1-0.2 part of borneol, 0.1-0.3 part of camphor and 0.1-0.25 part of essence through dissolution. The auxiliary material C is prepared from 0.3-0.6 part of phenoxyethanol. The auxiliary material B and the auxiliary material C are sequentially sprayed in the main material A to stir to uniformly mix, and the mixture is bagged after passing inspection to form the infantile talcum powder. The infantile talcum powder is prepared by taking pure natural pine tree pollen and the corn starch as main ingredients, adding a small amount of zinc oxide and using the borneol and the camphor as auxiliary raw materials according to the characteristic of infantile soft skin. Long-term clinical trials show that the infantile talcum powder has an obvious effect on infantile dermatitis, eczema and red buttock and does not have untoward effect.
526,276. Coatings for medicaments. KODAK, Ltd. March 11, 1939, No. 7907. Convention date, March 11, 1938. [Class 81 (i)] [Also in Group IV] Medicaments are covered with an enteric coating of a cellulose derivative containing free carboxyl groups. Such substances are prepared by reacting cellulose or a cellulose derivative containing free and available hydroxyl groups with a polycarboxylic acylating agent either in the presence of a tertiary organic base or in a suitable solvent. Examples are given in which cellulose, cellulose acetate and ethyl cellulose are reacted with phthalic anhydride and succinic anhydride. In one example, cyclohexane is used as a solvent. Other cellulose derivatives which may be used for the reaction are the propionate, butyrate, acetatepropionate, acetate-butyrate and the butyl and benzyl ethers ; diglycollic and maleic anhydrides are mentioned as other acylating agents. Increase in the amount of inert ester or ether in the product gives a decreased solubility in water, acid and alkali, while increase in the free carboxyl content causes increase in the solubility in alkali. The preferred carboxyl content is 5-25 per cent. and particularly the range 9-15 per cent. The substance to be coated may be dipped direct in a solution of the product in a suitable solvent or may be first covered with gelatine. The solvents used in the examples are dioxan, a mixture of ethylene dichloride and methyl alcohol and a mixture of ethyl lactate, water and ethyl alcohol. Triacetin, tripropionin, ethyl acid phthalate, butyl acid phthalate and ethyl acid adipate may be incorporated with the cellulose derivative to act as plasticizers and also fats and waxes may be added.
UNLABELLED: Meropenem penetration into the cerebrospinal fluid (CSF) is subject to high interindividual variability resulting in uncertain target attainment in CSF. Recently, several authors recommended administering meropenem as a continuous infusion (CI) to optimize CSF exposure. This study aimed to compare the concentrations and pharmacokinetics of meropenem in CSF after intermittent infusion (II) and CI. This prospective, observational study (NCT04426383) included critically ill patients with external ventricular drains who received either II or CI of meropenem. Meropenem pharmacokinetics in plasma and CSF were characterized using population pharmacokinetic modeling (NONMEM 7.5). The developed model was used to compare the concentration-time profile and probability of target attainment (PTA) between II and CI. A total of 16 patients (8 CI, 8 II; samples: nplasma = 243, nCSF = 263) were recruited, with nine patients (5 CI, 4 II) suffering from cerebral and seven patients from extracerebral infections. A one-compartment model described the plasma concentrations adequately. Meropenem penetration into the CSF (partition coefficient (KP), cCSF/cplasma) was generally low (6.0%), exhibiting substantial between-subject variability (coefficient of variation: 84.0%). There was no correlation between the infusion mode and KP, but interleukin (IL)-6 measured in CSF showed a strong positive correlation with KP (P < 0.001). Dosing simulations revealed no relevant differences in CSF concentrations and PTA in CSF between CI and II. Our study did not demonstrate increased penetration rates or higher concentrations of meropenem in the CSF with CI compared with II.
CLINICAL TRIALS: This study is registered with ClinicalTrials.gov as NCT04426383.
276,024. I. G. Farbenindustrie Akt.- Ges. Aug. 14, 1926, [Convention date]. Bacteria, cultivating; antitoxins, toxins, and immunizing and like serums.-Anti-serums are obtained from rod-like bacilli which are stated to be found in cases of scarlet fever but which differ from the usual scarlet fever hµmolytic streptococci. The cultural and morphological characteristics, which resemble those of the diptheria bacillus, are described. Modified forms of the bacilli, found in the blood of patients suffering from various complications following scarlet fever, may be used. For the production of anti-serums, animals such as cows or horses are injected with suspensions of the bacilli grown on solid media, or with cultures in liquid media, or with both; or injections may be made with mixtures of the normal bacillus with its modified forms, or with scarlet fever streptococci, or both, or with other species of bacteria or their toxins found in scarlet fever patients, or instance stophylococci and proteus bacilli. Mixed cultures or mixtures of separate cultures may be used, or successive injections may be made. The bacilli may be grown in media containing carotin, on ordinary agar covered with a layer of blood into which the bacilli are inoculated superficially, in media containing lipoids, in beef broth containing 2 per cent of peptone, or on L÷fflers serum. Toxins are produced in broth cultures but not when solid media are used.
One the day of frozen-thawed embryo transfer, frozen embryos will be thawed and incubated for at least 10 minutes in embryo transfer medium. For women allocated to the HA group, EmbryoGlue (Vitrolife), a hyaluronan-enriched embryo transfer medium, will be used as embryo transfer medium. EmbryoGlue contains a higher concentration of hyaluronan than the control medium.
Pyrimethamine is well absorbed with peak levels occurring between 2 to 6 hours following administration. It is eliminated slowly and has a plasma half-life of approximately 96 hours. Pyrimethamine is 87% bound to human plasma proteins. 

  


Microbiology: Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against Toxoplasma gondii. 

The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides. This was demonstrated by Eyles and Coleman1 in the treatment of experimental toxoplasmosis in the mouse. Jacobs et al2 demonstrated that combination of the 2 drugs effectively prevented the development of severe uveitis in most rabbits following the inoculation of the anterior chamber of the eye with toxoplasma.
The invention discloses a traditional Chinese medicine formula for treating blood-deficiency type chronic pharyngitis. The invention is characterized in that the formula is prepared from the following raw materials: 25 g of Radix Astragali, 10 g of Chinese angelica, 15 g of Poria cocos (Schw.) Wolf, 20 g of polygala root and 20 g of licorice. The preparation method and application method comprise the following steps: washing Radix Astragali, Chinese angelica, Poria cocos (Schw.) Wolf, polygala root and licorice, adding 2500 g of water and decocting, boiling with strong fire, decocting with slow fire for 25 min, filtering to remove slag, fetching a decoction; taking the formula orally twice a day. The traditional Chinese medicine formula for treating blood-deficiency type chronic pharyngitis has efficacy of nourishing blood and enriching blood.
Background and Objectives: Few U.S. women meet the public health recommendations to exclusively breastfeed for 6 months and continue breastfeeding for at least 1-2 years. We compared prenatally collected demographic, health, and breastfeeding support/intention variables to examine how these factors intersect to predict meeting breastfeeding recommendations. Methods: PREVAIL, a CDC-funded birth cohort in Cincinnati, OH, was approved by the IRB at CDC, Cincinnati Children's Hospital, and the hospitals where enrollment (third trimester, 2017-2018) occurred. The prenatal questionnaire captured sociodemographics, pre-pregnancy weight and height, breastfeeding environment, and breastfeeding intention, while health factors were obtained from obstetrical records. Body mass index (BMI) (kg/m2) was categorized as healthy (18.5-24.9), overweight (25-29.9), obesity 1 (30-34.9), and obesity 2+ (≥35). Mothers self-reported date of exclusive and any breastfeeding cessation through quarterly postnatal questionnaires. Random forest was used for variable selection, cross-validated in multivariable logistic models. Results: Analysis included n = 237 mothers with BMI ≥18.5. Random forest identified BMI category, prenatal intention, and insurance type as the most important predictors of meeting breastfeeding recommendations. The resulting logistic models explained >40% of the variance with an area under the curve of ≥0.89 for both recommendations. More than 73% of the risk of not meeting breastfeeding recommendations was attributable to having an elevated BMI or lacking strong breastfeeding intention. Conclusions: In PREVAIL, maternal BMI and prenatal intention explained most risks of not meeting breastfeeding exclusivity and duration recommendations. Our findings suggest efforts to improve breastfeeding exclusivity and duration should focus on strengthening prenatal breastfeeding intention and identifying effective interventions for supporting breastfeeding among mothers with higher BMI.
PROBLEM TO BE SOLVED: To obtain the subject new water-soluble compound, an antibiotic derived for microorganism belonging to the genus Amycolatopsis, having excellent antibacterial activity against Gram-positive bacteria, esp. highly resistantized MRSA, thus useful as an antimicrobial agent. SOLUTION: This compound is a new amythiamicin amide derivative (salt) of formula I  (n) is an integer of 1-6; R<1> is H, carboxyl or hydroxymethyl; R<2> is a group of the formula COOR<3> [R<3> is H, a lower alkyl or (substituted) benzyl], methyl, OH, guanidino group, etc.}, being useful as an antimicrobial agent for medical use, esp. e.g. an antibacterial agent effective on drug-resistant MRSA. This compound is obtained by hydrolyzing an amythiamicin of formula II as a methanolysis product from an antibiotic amythiamicin A yielded by culturing MI481-42F4 strain belonging to the genus Amycolatopsis (FERM P-12739) followed by reaction of the resultant hydrolyzate with an amine derivative of formula III.
Induced overexpression of defined exogenous transcription factors (TFs), or alternatively treatment with specific pathway modulatory cocktails, can reprogram somatic cells to pluripotency or alternate cell states. A barrier to initiating reprogramming lies in the starting cell's molecular identity, enforced by lineage-instructive TFs. However, it remained unclear whether repression of such somatic lineage-defining TFs of the starting cell in the absence of exogenous TFs is sufficient to induce cell reprogramming. Using an intra-species somatic cell hybrid model, SNAI2 and PRRX1 were identified as the most critical determinants of mesenchymal commitment in rat embryonic fibroblasts (REFs) and demonstrate that siRNA-mediated transient knockdown of these individual factors is adequate to convert REFs into functional adipocytes, chondrocytes or osteocytes without requiring the provision of exogenous TFs. Additionally, it was shown that siRNA-mediated transient knockdown of SNAI2 alone, in the absence of exogenous TFs, is sufficient to transform REFs to a dedifferentiated pluripotent stem-like cell (dPSC) state that forms embryoid bodies and is capable of triple germ layer differentiation. These results establish for the first time that transient repression of a single somatic lineage-defining TF can effectively induce transdifferentiation to alternative somatic cell states or dedifferentiation to dPSCs in the absence of exogenous TFs or small molecule cocktails.
Following the implantation of a carotid artery stent (CAS), the aetiology of in-stent occlusion typically shifts from embolic events in the acute phase to intimal hyperplasia in the chronic phase. A man in his 70s with a history of CAS implantation (performed 5 years ago) for left internal carotid artery (ICA) stenosis was admitted to our hospital with a chief complaint of left-sided transient scotoma. MRI revealed an acute occlusion of the left ICA, and an urgent digital subtraction angiography (DSA) was performed. The DSA results suggested the presence of an in-stent thrombus instead of in-stent stenosis. An urgent endovascular thrombectomy was performed, and the thrombus was successfully retrieved from the carotid stent. Full reperfusion was achieved, and no damage occurred to the carotid stent. This case highlights the importance of thorough examination of MRI and DSA findings for accurate differentiation between the causes of vessel occlusion.
This study aims to determine which topics in alcohol warning labels are most effective at making US adults who consume alcohol want to drink less alcohol, which topics best remind consumers of alcohol's harms, and which topics are most likely to teach consumers something new. The survey research company NORC at the University of Chicago will recruit a sample of 1,000 US adults ages 21+ who consumed alcohol at least one time per week during the past 4 weeks.

Participants will complete a within-subjects online randomized experiment in which they view and rate messages shown on alcohol containers. Participants will rate each message on perceived message effectiveness (primary outcome), reminding of alcohol's harms (secondary outcome), and learning something new (secondary outcome). These tasks will be repeated for 10 messages, each with a different topic. There will be 9 warning topics (i.e., topics about alcohol's harms) and 1 control topic (i.e., neutral topic not about alcohol's harms). In this within-subjects experiment, the survey will present the topics in random order and participants will view 1 of 2 messages for each topic.
This is a single arm study so this arm will include all eligible subjects. All subjects will have radiosurgery 1-4 days prior to surgical resection.
This study is a Phase I study of the safety and immunogenicity of recombinant Staphylococcal Enterotoxin B vaccine (STEBVax) in healthy adults. STEBVax is a recombinant mutated form of staphylococcal enterotoxin B (SEB) containing three point mutations that disrupt the interaction of the toxin with human major histocompatibility complex (MHC) class II receptors and render the protein non-toxic while retaining most of the immunogenicity. The primary intended result of this program is the development of a hyperimmune serum for treatment of toxic shock syndrome (TSS) originating from nosocomial, environmental or potential bioterrorist events. An additional long-term goal is the development of a multivalent vaccine and immunotherapeutic for treating or preventing diseases caused by Staphylococcus (S.) aureus. The long-range goal is to develop a vaccine that will protect against a broad range of staphylococcal superantigens. The primary objective is to evaluate and assess the safety of parenterally administered STEBVax vaccine in healthy adult subjects over a range of doses from 0.01 to 20 mcg by intramuscular injection. The secondary objectives are to determine the immunogenicity of STEBVax vaccine over a range of doses as determined by the rate and titer of seroconversion with serum anti-S. aureus enterotoxin B IgG antibodies measured by enzyme-linked-immunosorbent serologic assay (ELISA). Participants will include 28 healthy adult subjects from the University of Maryland Baltimore community. Subjects will receive a dose of STEBVax in Alhydrogel adjuvant at one of the following doses: 0.01, 0.1, 0.5, 2.5, 10 or 20 mcg or 2 doses of 20 mcg given 21 days apart. STEBVax will be administered as a single 0.5 mL intramuscular injection. Subjects will be followed for safety, reactogenicity, and immune response after vaccination. Subjects will be observed in the clinic for at least 8 hours after vaccination and remain in the Baltimore-Washington metropolitan area for 7 days after vaccination.