anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In order to meet the optimal nutritional needs of HIV-infected infants, it is critical that nutritional intervention begin early. Early nutritional intervention may help reduce the susceptibility to or severity of primary HIV and/or opportunistic infections and add to the quality of life for children perinatally infected with HIV.

\[AS PER AMENDMENT 08/29/01: This study population will consist of infants from domestic sites and international sites.\] In this double-blind, controlled study perinatally HIV-exposed infants less than 15 days old \[AS PER AMENDMENT 08/29/01: "less than 15 days old" has been replaced with: less than 17 days old\] at time of study entry are randomized to 1 of 2 arms to receive either concentrated formula or standard formula for 8 weeks after being stratified by gestational age: less than 37 versus greater than 37 completed weeks. At the 8-week visit using a previously determined 8:1 random allocation, 89% of singleton infants \[AS PER AMENDMENT 08/29/01: from international sites\] with negative HIV-specific tests are discontinued from study treatment and further follow-up. The other 11 percent of these singleton infants with negative HIV-specific tests continue study treatment with open-label standard formula until Week 28 (control group). Singleton infants with positive HIV-specific tests continue on the blinded portion of the study and receive formula as initially assigned until Week 28. For a given multiple birth, if any of the infants at the 8-week study visit are determined to be infected, all the infants from that birth continue their initial blinded treatment assignment until Week 28; if none of the infants are determined to be infected at this time, all the infants from that birth continue study treatment with open-label standard formula until Week 28. All infants assigned to receive study treatment through Week 28 continue study follow-up until 12 months of age. A subset of patients at sites with appropriate resources will participate in a substudy in which measurements of triceps and thigh skinfold thickness and circumference and thigh density DEXA scans are evaluated.
PURPOSE:To obtain a hairdressing having excellent effects on hair growth by blending a hairdressing prepared by blending a base consisting of ethanol for splitting fats and oils, purified water, etc., with a blood stream promoter, astringent agent, hair growth agent, etc., with extract essences of Panax japonicus C.A. Meyer and Polygonum multiflorum Thunb. CONSTITUTION:A hairdressing obtained by blending a hairdressing prepared by blending a base consisting of ethanol for splitting fats and oils, purified water and a humectant with a Capsicum tincture as a blood stream promoter, menthol as an astringent agent, hinokitiol, Matricaria chamomilla L. and Glycyrrhizae Radix as a hair growth agent with extract essences of Panax japonicus C.A. Meyer and Polygonum multiflorum Thunb. The ethanol and extract essence of Polygonum multiflorum Thunb. effectively act on the splitting of the fats and oils and the Capsicum tincture and extract essence of Panax japonicus C.A. Meyer effectively act on blood stream promotion by stimulating the scalp to improve permeability of the hair growth agent into hair roots and exhibit excellent effects on hair growth.
RX-5902 will be taken daily for 4 weeks in each 4 week cycle. Subjects will be fasting for 8 hours before and food may be ingested approximately 3 hours after the dose has been administered.
Besides the usual excipients and additives, a medicament contains a compound having formula (I), in which A and B, which are the same or different, each stand for a phenyl residue substituted if desired by halogen, hydroxy, C1?-C6? alkyl or C1?-C6? alkoxy, or together stand for a -CH=CH-CO-CH=CH- group; X stands for oxygen and y for a methylene group or X stands for a -CH2?O- group and Y for a valency bond; and R stands for a spirolinked C3?-C6? cycloalkane residue or for a spirolinked C3?-C6? lactone residue. Also disclosed are its enantiomers, diastereomers and racemates said medicament is useful in treating acute and chronic allergic, non-allergic and traumatic inflammatory diseases. New compounds having the formula (I) and a process for preparing the same are described.
OBJECTIVES: Recent studies have suggested that older adults with hearing loss (HL) are at a greater risk of postural instability than those with normal hearing. However, little is known regarding this association in middle-aged individuals. The relationships between HL laterality, asymmetric hearing, and posture control are similarly unclear. The purpose of this study was to investigate the effects of hearing status on postural control and to explore the dose-response relationship between the hearing threshold and postural instability risk in middle-aged adults.
DESIGN: This cross-sectional study included 1308 participants aged 40 to 69 years with complete audiometric and standing balance function data from the 2001-2004 National Health and Nutrition Examination Survey. Speech-frequency HL was defined as a pure-tone average at 0.5, 1, 2, and 4 kHz of >25 dB in the better-hearing ear; high-frequency HL was defined as a pure-tone average at 3, 4, and 6 kHz of >25 dB. Asymmetric hearing was defined as a difference in the pure-tone average >15 dB between ears. Postural instability was defined as participants ending the modified Romberg test in condition 4.
RESULTS: After adjustment for sociodemographic variables, lifestyle, and comorbidities, speech-frequency HL, except for unilateral HL, was associated with increased postural instability (mild HL: odds ratio [OR], 2.33; 95% confidence interval [CI], 1.25-4.35; moderate-to-severe HL: OR, 3.59; 95% CI, 1.61-8.03). Compared with individuals with normal bilateral hearing, participants with bilateral HL also showed a higher risk of postural instability (OR, 2.88; 95% CI, 1.61-5.14). The OR for postural instability among participants with asymmetric hearing compared with those with symmetric hearing was 2.75 (95% CI, 1.37-5.52). Furthermore, each 10 dB increase in the speech-frequency hearing threshold was associated with a 44% higher risk of postural instability.
CONCLUSIONS: Hearing loss is associated with poorer postural control. Individuals with asymmetric hearing have a higher postural instability risk compared with those with symmetric hearing. Further studies are needed to confirm these findings and the causality. Moreover, future studies are warranted to assess whether hearing aids are beneficial for the restoration of impaired balance functions.
<P>PROBLEM TO BE SOLVED: To provide a composition which is applied or taken to prevent the acid production of a dental caries-causing bacterium.  <P>SOLUTION: This dental caries induction-preventing action composition is characterized by containing difructose anhydride as an active ingredient. The composition may further contain xylitol, maltose, palatinit, mannitol, sorbitol, palatinose, panose oligosaccharide, lactitol, erythritol, coupling sugar, and/or isomaltooligo. The composition relates to the prevention in the acid production of a dental caries-causing bacterium, and can prevent the dental caries. The composition can be used as an oral composition, medicine, and food or drink for human being or animals.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The invention relates to a traditional Chinese medicine recipe for treating pneumonia. The traditional Chinese medicine recipe comprises, by mass, 6-10 parts of physalis alkekengi, 8-12 parts of solanum nigrum L., 4-8 parts of riparian homonoia roots, 8-12 parts of plum-leaved holly, 2-6 parts of trichosanthes peel, 8-12 parts of bamboo shavings, 4-8 parts of fermented soybeans, 10-14 parts of centipeda minima, 4-8 parts of semen cuscutae, 8-12 parts of rhizoma cimicifugae, 4-8 parts of thalictrum javanicum Blume roots, 8-12 parts of sarcandra glabra (Thunb.) Nakai, 4-8 parts of herba corydalis bungeanae, 8-12 parts of herba tripterospermi, 4-8 parts of crotalaria albida, 8-12 parts of pygmy fruit of peaches, 4-8 parts of Chinese pulsatilla roots, 8-12 parts of bischofia javanica, 4-8 parts of hoya carnosa (L. f.) R. Br., 8-12 parts of lumbricus, 4-8 parts of tatarian aster roots, 8-12 parts of loguat leaves and 4-8 parts of folium eucalypti. The traditional Chinese medicine recipe for treating the pneumonia is capable of dispersing the lung, relaxing the bowel, clearing and purging heat accumulation, promoting blood and qi circulation, strengthening healthy energy and removing pathogenic factors, has a good treatment effect on pneumonia treatment by means of cooperation of all medicines and is excellent in efficacy when used clinically every time. Sixty patients' use results of the traditional Chinese medicine recipe in the past three years show that the traditional Chinese medicine recipe is capable of effectively treating the pneumonia, and the effective rate is as high as 91.67%.
BACKGROUND: There is no consensus on the most effective strategy for Postoperative Pulmonary Complication (PPC) reduction. This study hypothesized that a Goal-Directed Fluid Therapy (GDFT) protocol of infusion of predetermined boluses reduces the occurrence of PPC in patients undergoing elective open abdominal surgeries when compared with Standard of Care (SOC) strategy.
METHODS: Randomized, prospective, controlled study, conducted from May 2012 to December 2014, with ASA I, II or III patients undergoing open abdominal surgeries, lasting at least 120 min, under general anesthesia, randomized into the SOC and the GDFT group. In the SOC, fluid administration was according to the anesthesiologist's discretion. In the GDFT, the intervention protocol, based on bolus infusion according to blood pressure and delta pulse pressure, was applied. Patients were postoperatively evaluated by an anesthesiologist blinded to the group allocation regarding PPC incidence, mortality, and Length of Hospital Stay (LOHS).
RESULTS: Forty-two patients in the SOC group and 43 in the GDFT group. Nineteen patients (45%) in the SOC and 6 in the GDFT (14%) had at least one PPC (p = 0.003). There was no difference in mortality or LOHS between the groups. Among the patients with PPC, four died (25%), compared to two deaths in patients without PPC (3%) (p = 0.001). The LOHS had a median of 14.5 days in the group with PPC and 9 days in the group without PPC (p = 0.001).
CONCLUSION: The GDFT protocol resulted in a lower rate of PPC; however, the LOHS and mortality did not reduce.
A composition and method for separating red blood cells from whole blood comprising a rouleaux-forming aggregator and an enhancer for enhancing the settling rate. The enhancer is a material which alters directly or indirectly the properties of the red blood cell and may alter the structure and/or reactivity of the aggregator, without adversely affecting the morphology and function of white blood cells. In most instances, the red blood cell enhancers of the invention are osmotic agents. Such agents create a hypertonic solution while not entering the cells themselves. Preferably the enhancer is a salt of oxalic acid, a salt of malonic acid, mannitol or sucrose. Potassium oxalate is most preferred. High molecular weight substances which are large enough to form molecular bridges between red blood cells form the aggregators used in the invention. Examples of useful aggregators include dextran, hespan, pentaspan, ficoll, gum arabic, polyvinylpyrrolidone, nucleic acids, and proteins such as fibrinogen and gamma globulins.
Group B will consist of 6 subjects who will receive 2.85x10\^11 molecules of AAVrh.10CUCLN2, the gene transfer vector carrying the CLN2 gene. This is equal to 285,000,000,000 molecules of the drug. The drug will be administered only once in the study.
Like African-American women, African-American girls suffer disproportionately from obesity and Type 2 diabetes mellitus. One factor strongly associated with the development of obesity and Type 2 diabetes mellitus disparities in children is low physical activity levels. Low physical activity is more prevalent in African-American girls, pointing to the critical need for effective physical activity interventions. For a physical activity intervention message to be effective among African-American girls, the program must be enjoyable and tailored to African-American girls and women. One possibility for an appropriate physical activity intervention is afro-centric dance, which has strong cultural and historical significance in the African-American community. This form of physical activity may provide girls with sustained bouts of moderate-to-vigorous physical activity. There appears to be a strong positive correlation between parental and children physical activity levels. In the African-American culture, maternal health behaviors in particular have a strong influence on children's health behaviors. Currently, there are no studies that examine the effects of a daughter-mother Afro-centric dance program on the physical activity levels of African-American girls. Therefore, the purpose of this study will be to examine the feasibility and efficacy of a 12-week physical activity intervention consisting of afro-centric dance and its ability to affect the physical activity levels of African-American girls. If investigators identify afro-centric dance as a sustainable form of physical activity for African-American daughters and mothers, investigators can use this intervention to significantly reduce obesity and Type 2 diabetes mellitus in these groups.
This is multicenter, open-label (identity of assigned study drug will be known) one-arm study in pediatric participants receiving general anesthesia. The participants are children aged 1-15 years old, planned to undergo head and neck, thoracic (except heart), urological, orthopedic or plastic surgery. Approximately 80 participants will be enrolled in this study. These participants are divided into two groups by age (1-6 and 7-15 years old). Pharmacokinetic (what the body does to the drug,) blood samples will be collected from at least 3 participants between the ages of 1 and 6 years and at least 3 participants between the ages of 7 and 15 years from 15 minutes after the start of infusion to the end of infusion of the study drug . The study consists of 4 phases: screening phase, treatment phase, recovery phase and follow-up phase. Screening for eligible participants will be performed within 14 days before administration of the study drug. The safety and tolerability of study drug will be evaluated by physical examinations, electrocardiogram (ECG), clinical laboratory tests, vital signs, and adverse events (AEs) according to the Time and Events Schedule. Participants safety will be monitored throughout the study.
INTRODUCTION: Despite its existence for more than 40 years, the TEM method has not become widespread. The main reasons are the high acquisition costs, the sophisticated technology and alternative procedures (especially radical resection procedures), which provide greater oncological safety. However, avoiding major abdominal surgery with the creation of a stoma and higher complication rates can outweigh the higher risk of recurrence for some patients. We examined the results using V-TEM with reduced acquisition costs in the resection of adenomas and carcinomas and discussed its importance by literature .
METHOD: From 2003 to 2019, 154 patients with 170 findings were operated by V-TEM technology. Data on the operation and follow-up were collected and analyzed retrospectively.
RESULTS: The median age was 67 years, 89 patients were male and 65 female. V-TEM was performed on 79 carcinomas, 77 adenomas and 14 other findings. The complication rate was 21.2 %. R0 resection was achieved in 78.8 %. The adenoma recurrence rate was 7.3 %, the overall recurrence rate for carcinomas 11.9 %, local recurrences were observed in 6.8 %. The disease-specific survival is 100 % at 5 years and 94.2 % at ten years.
DISCUSSION: The successful use of TEM in adenomas and early carcinomas is undisputed. When treating carcinomas from a T1 high risk stage using TEM, recurrence rates higher than 10 % must be expected. Better results can be achieved with radical procedures, this is why they are considered the therapy of choice in these cases. However, there are no differences in terms of survival rates and TEM offers proven better postoperative quality of life. In particular, the combination of neoadjuvant procedures with TEM delivered promising results in more advanced stages. Further studies on TEM and the possibility of lower acquisition costs through modification to V-TEM could make the method more popular in the future.
The invention discloses lipid-lowering extract from effective parts of sharpleaf galangal fruit and preparation and application thereof. The lipid-lowering extract from effective parts of sharpleaf galangal fruit includes effective ingredients, such as oligosaccharide, polysaccharides, flavonoid and diarylheptanoid compounds. The invention further discloses the preparation method of the lipid-lowering extract from effective parts of sharpleaf galangal fruit. The preparation method includes the steps of firstly, performing percolation extracting to coarse powder of sharpleaf galangal fruit by ethanol; secondly, decompressing and concentrating percolation extract to obtain concentrated alcoholic extract; and thirdly, extracting the concentrated alcoholic extract by organic solvents different in polarities, mixing insoluble in the extracting processes, and drying to obtain the lipid-lowering extract. Pharmacodynamic researches show that the lipid-lowering extract from effective parts of sharpleaf galangal fruit is highly effective in lowering blood lipid, capable of lowering abnormally rising TC (total cholesterol), TG (triglyceride) and LDL-C (low-density lipoprotein cholesterol) levels and increasing HDL-C (high-density lipoprotein cholesterol) level, and also capable of causing change in composition of subfractions of HDL. The lipid-lowering extract from effective parts of sharpleaf galangal fruit can be made into drugs for lowering blood lipid or treating hyperlipidemia.
The aim of this clinical trial is to evaluate the value of circulating tumor cell detection in the early diagnosis of malignant pulmonary nodule. Patients with clinical suspected malignant pulmonary nodules will be included in this trial. Peripheral blood of participants will be collected before surgery or biopsy. Clinical and imaging data of enrolled patients will also be collected. Pathological diagnosis is the gold standard for differentiating benign and malignant pulmonary nodules. The sensitivity and specificity of CTC detection for diagnosing malignant pulmonary nodules will be analyzed.
Screening high-risk populations is crucial for the prevention and treatment of kidney stones. Here, we employed radiomics to screen high-risk patients for kidney stones. A total of 513 independent kidneys from our hospital between 2020 and 2022 were randomly allocated to training and validation sets at a 7:3 ratio. Radiomic features were extracted using 3Dslicer software. The least absolute shrinkage and selection operator (LASSO) method was used to select radiomic features from the 107 extracted features, and logistic regression, decision tree, AdaBoost, and support vector machine (SVM) models were subsequently used to construct radiomic feature prediction models. Among these, the logistic regression algorithm demonstrated the best predictive performance and stability. The area under the curve (AUC) of the logistic regression model based on radiomic features was 0.858 in the training cohort and 0.806 in the validation cohort. Furthermore, univariate and multivariate logistic regression analyses were performed to identify the independent risk factors for kidney stones, which were gender and body mass index (BMI). Combining these independent risk factors improved the predictive performance of the model, with AUC values of 0.860 in the training cohort and 0.814 in the validation cohort. Clinical decision curve analysis (DCA) indicated that the radiomic model provided clinical benefit when the probability ranged from 0.2 to 1.0. The radiomic model has a good ability to screen high-risk patients with kidney stones, facilitating early intervention in kidney stone cases and improving patient prognosis.
Each participant will receive SOC plus sotatercept at a dose of 0.3 mg/kg SC for Cycle 1. (Each cycle will be 21 days.) From Cycle 2 through Cycle 9, the dose will be escalated to 0.7 mg/kg SC. Dosing will be every three weeks during the 24-week treatment period and 18-month extension period.
Although the exact relationship between posture and NSNP is unsettled, the posture of the cervical spine appears to influence dorsal neck muscle activity at rest and during movement. Additionally, the forward head posture associated with thoracic kyphosis indirectly affects cervical flexion and rotational range of motion (ROM) also sustained computer work and prolonged using smart phones often in positions that encourage a functional kyphosis, appears to modify neck posture, as well as scapular positioning and upper trapezius muscle activity. Besides that Ergonomic intervention, including adjustments of the workplace station and postural correction, have been demonstrated to be effective in reducing NP with some work conditions. In addition, modalities that used to correct sagittal alignment of the cervical spine proved statistical and clinically significant results related to pain, disability, and improved nerve function. That is accomplish cause and effect relationship between bad posture and neck symptoms. According to the systematic review of Anabela et al., about head posture assessment useful for neck patients or not? The answer, of course, was yes, but it must be considered in relation to the patient's symptoms and related functional problems. Harrison and his colleagues reported that posture abnormalities occurred in the head, ribs, and pelvis in three dimensions in the form of translations and rotational displacements. Therefore, we should consider three dimensional (3D)postural assessment and correction during the treatment of NSNP associated with significant posture problems of the head in relation to thoracic. Growing research about using mirror image traction during ambulatory exercise, which is prescribed specifically to help normalize the patient's neuromuscular dysfunction and postural deformation via reflecting the patient's posture across different planes, is more beneficial than a less personalized program. With these considerations in mind and to combine the findings of 3D postural assessment into the treatment program, we designed adjustable 3D posture corrective orthotic (PCO) to be worn by the patient for a short time. The device has the ability to reflect all transitional displacements and rotational movements of the head then ask the patient to make ambulatory exercise using a treadmill while the PCO holds the patient's reverse posture. To our knowledge, no randomized clinical trial (RCT) had evaluated the addition of a 3D adjustable PCO to usual care program and investigate its short- and moderate-term improvement effects on NSNP management outcomes (i.e., neck pain, neck disability and 3-dimensional posture parameters of the head). The primary aim of our study was to evaluate of conducting an RCT using neck disability index (NDI )and 3D posture parameters. The secondary aim was NPRS and Active CervicalROM. investigate the effect size of the addition of ambulatory mirror-image traction via the wearing of 3D adjustable PCO compared to control group interventions for neck pain, disability, and 3D posture parameters.