anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The initial transluminal puncture of the bile duct is performed by endoscopic ultrasound guidance (longitudinal echoendoscope) with an 19 G access needle. After injection of a radiopaque contrast media into the bile duct system, the malignant extrahepatic bile duct stenosis can be visualized by fluoroscopic guidance. Then, a 0.035 inch guide wire is introduced into the bile duct. After dilatation of the transluminal access route with a balloon catheter, a self-expandable metal stent is introduced as an antegrade biliary drainage, a transhepatic biliary drainage or a choledochal biliary drainage. The placement of the metal stent is controlled by fluoroscopic and endoscopic luminal guidance.
To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the Physician’s Desk Reference (PDR). In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient.

Protect the patient’s airway and support ventilation and perfusion. Meticulously monitor vital signs, blood gases, blood chemistry values, and other variables.

If convulsions occur, consider diazepam, phenytoin, or phenobarbital. If the seizures are refractory, general anesthesia with thiopental or halothane and paralysis with a neuromuscular blocking agent may be necessary.

For hypotension, consider intravenous fluids, elevation of the legs, and an inotropic vasopressor, such as dopamine or norepinephrine (levarterenol). Theoretically, calcium gluconate may be helpful in treating some of the toxic cardiovascular effects of papaverine; monitor the ECG and plasma calcium concentrations.

Forced diuresis, peritoneal dialysis, hemodialysis, or charcoal hemoperfusion have not been established as beneficial for an overdose of papaverine hydrochloride.
Participants randomized to this arm of the study will be randomized a second time into one of three groups. Participants in this group will attend one 2-hour class to be introduced to the intervention and will receive a workbook to use at home.
Methods, systems, and computer-readable media are disclosed herein for securing electronic data that includes personally identifying information. In embodiments, a message is obtained that includes personally identifying information encoded as electronic data. In the message, segments, fields, field components, and/or field subcomponents is/are identified that contain personally identifying information data. In embodiments, the values format(s) of those elements are recognized. The personally identifying information data is removed from the message. Then, for each of the fields, field components, and/or field subcomponents from which the personally identifying information data is removed from message, non-PHI data that conforms to the value format(s) is inserted into the message.
Sol-gel inorganic porous particles are composed of an inorganic compound that provides an inorganic solid phase including an external particle surface. They also have a first set of pores wherein the pores have an average diameter of less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm, which second set of pores contains stabilizing organic microgel particles. These inorganic porous particles are prepared using a first oil phase comprising a first water-immiscible aprotic solvent having a dielectric constant of less than 10 and having dissolved therein organic microgel particles. An aqueous phase comprising a polar solvent, an inorganic gel precursor, a catalyst, and a dispersing surfactant is neutralized to initiate condensation of the inorganic gel precursor. An oil-in-water emulsion is then formed with the organic microgel particles in the first oil phase, which is dispersed as first oil phase droplets in the aqueous phase. A second oil phase is combined with the oil-in-water emulsion with the second oil phase to form an oil-in-water-in-oil emulsion comprising the first oil phase droplets in the aqueous phase.
PURPOSE:To obtain a new compound, having excellent inhibiting actions on lipoxygenases and useful for treating and preventing allergic asthma, bronchitis, rheumatism, thrombosis, angina pectoris, arteriosclerosis, etc., or protecting, etc., cells in gastrointestinal tracts. CONSTITUTION:This compound is expressed by formula I [A is methylene or ethenyl; R<1> is a (substituted) hydroxynaphthyl or a 3,4-di-lower alkyl-4- hydroxyphenyl; R<2> is H, a lower alkyl or phenyl(thio)], e.g. 2-[(1,2,3-thiadiazol-4- yl)methyl]-1-naphthol. A compound in which A is methylene in the compound expressed by formula I is obtained by reacting, e.g. a compound expressed by formula II (X is Cl, Br, etc.) with 1-naphthol in the presence of an acidic catalyst such as boron trifluoride in a solvent. A compound in which A is ethenyl in the compound expressed by formula I is prepared by reacting, e.g. the compound expressed by formula II with triphenylphosphine, treating the resultant compound expressed by formula III with a base and then successively reacting the treated compound with a compound expressed by formula IV (R is a lower alkyl) and an acid.
These products are sterile, nonpyrogenic solutions of electrolytes in water for injection intended only for sterile irrigation, washing and rinsing purposes.

Each 100 mL of Ringer’s Irrigation, USP contains: Sodium chloride 860 mg; potassium chloride 30 mg; calcium chloride dihydrate 33 mg. The pH is 5.7 (5.0 — 7.5). The solution is isotonic (309 mOsmol/liter, calc.) and has the following electrolyte content (mEq/liter): Na+ 147.5; K+ 4; Ca++ 4.5; Cl− 156.

The solution contains no bacteriostat, antimicrobial agent or added buffer and is intended only for use as single-dose or short procedure irrigation. When smaller volumes are required the unused portion should be discarded. Ringer’s Irrigation, USP may be classified as a sterile irrigant, wash, rinse and pharmaceutical vehicle.

Calcium Chloride, USP is chemically designated calcium chloride dihydrate (CaCl2 • 2H2O), white fragments or granules freely soluble in water.

Potassium Chloride, USP is chemically designated KCl, a white granular powder freely soluble in water.

Sodium Chloride, USP is chemically designated NaCl, a white crystalline powder freely soluble in water.

Water for Injection, USP is chemically designated H2O.

The semi-rigid container is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The container requires no vapor barrier to maintain the proper drug concentration.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and secondary immunodeficiency disease (SID) are susceptible to severe, recurrent, or persistent infections. This retrospective cohort study assessed the burden of infection in patients with CLL/SLL with and without SID, and in immunoglobulin replacement therapy (IgRT)-treated and -untreated patients with CLL/SLL and SID. Anonymized data from the US Optum-Humedica database (Oct-1-2015-Mar-10-2020) were used. Eligible patients aged ≥ 18 years with a confirmed CLL/SLL diagnosis were assigned to cohorts (SID or no-SID) using an algorithm based on serum IgG levels < 5.0 g/L, hypogammaglobulinemia diagnosis codes, and ≥ 1 major infection. A further sub-categorization was made based on patients with SID who received IgRT and those who did not. During 12-month follow-up, patients with CLL/SLL and SID were significantly more likely to experience infections (70.1% vs. 30.4%), including severe bacterial infections (39.8% vs. 9.2%), and infections requiring hospitalization (27.7% vs. 5.8%) than patients without SID. The use of anti-infectives and healthcare resource utilization (HCRU) was also higher in the SID cohort versus the no-SID cohort. Overall survival was shorter in patients with SID than those without (12.3 vs. 16.9 months). In patients with CLL/SLL and SID, burden of infection and HCRU were greater in IgRT-treated patients than in no-IgRT patients, potentially highlighting the IgRT-treated cohort as a more vulnerable population. Increasing understanding of SID burden may help to improve outcomes in patients with CLL/SLL. Further research is needed to develop guidance for IgRT use and to assess the benefits of IgRT in this vulnerable population.
A hand-held device (1) for dispensing a metered quantity of a substance such as a pharmaceuticals, medicinal, or therapeutic substance, and applying that substance to the skin of a host animal. The device (1) includes a hollow body (2) that can be grasped by the hand of a user, and a substance capsule (4) mounted within that body. The capsule (4) includes a container (5) for the substance, and a nozzle (10) through which a quantity of the substance is dispensed, possibly in the form of a spray. The device (1) also includes actuator means (6,9) connected to the interior of the substance container (5) and operable to cause a metered quantity of the substance to be dispensed through the nozzle (1). The actuator means (6,9) may include a manually operable pump (6), or it may include a valve that is selectively operable to prevent or permit pressurized contents of the container (5) escaping in the form of an aerosol. In the former case, the pump (6) may be operated through an actuator button (9), and in the later case the valve may be opened through operation of an actuator button (9). The device (1) also includes means for preventing or minimising unintentional loss of the stored substance. In one form, that means includes a closure member (2) that is operable to close or open the nozzle outlet. In another form it includes an absorption pad (31) onto which an initial quantity of the substance is deposited, and which is thereafter removed to permit normal operation of the device (1). If a closure member (20) is used, means may be provided to apply a force to that member so as to ensure effective closure of the nozzle outlet. Substance emerging from the nozzle (10) is received within a shroud (13) for confining the dispensed substance to a designated target area, and which may also function to position the nozzle (1) at a suitable distance from the target area.
The study team will develop and test a novel tailored behavioral intervention for patients of a Federally Qualified Health Center who are recently diagnosed with COVID-19. The study is a pragmatic, quality improvement randomized controlled trial (RCT). This research is looking to enroll 256 index patients and their households. Index patients and their households will be invited to participate in the COVID Prevention Program, which includes free COVID-19 testing for exposed household members. Index patients will be randomized to one of two groups: (a) the Standard-of-Care comparison group who will receive established clinical care and follow-up, or (b) the Enhanced Standard-of-Care group, who will receive standard-of-care plus tailored, real-time mobile/virtual counseling delivered by promotores/as. The intervention will use theory- and evidence-based strategies for behavior change and maximize the use of mobile phone applications and technologies to capture real-time behavioral, social, and contextual data (via Ecological Momentary Assessment). The intervention will utilize motivational interviewing techniques to tailor strategies to index patients' home environment/context and social/emotional needs. The intervention will target immediate risk of household spread, followed by risk of community spread. The primary outcome assessed will be a new positive antibody test within a household (post-baseline), as assessed by a blood draw collected by a certified phlebotomist. Secondary research outcomes will be assessed via self-report surveys. Surveys will include socioeconomic status indicators and demographics, as well as measures of mental health (e.g., depression), physical health (chronic conditions), health behaviors (social distancing, hand washing \& wearing face covering), as well as comorbidities and risk factors for severe COVID-19 outcomes. Primary and secondary outcomes will be measured at 5 timepoints: baseline, 6-weeks, 6-months, 12-months, and 24-months.
Implanted biomaterials and devices face compromised functionality and efficacy in the long term owing to foreign body reactions and subsequent formation of fibrous capsules at the implant-tissue interfaces1-4. Here we demonstrate that an adhesive implant-tissue interface can mitigate fibrous capsule formation in diverse animal models, including rats, mice, humanized mice and pigs, by reducing the level of infiltration of inflammatory cells into the adhesive implant-tissue interface compared to the non-adhesive implant-tissue interface. Histological analysis shows that the adhesive implant-tissue interface does not form observable fibrous capsules on diverse organs, including the abdominal wall, colon, stomach, lung and heart, over 12 weeks in vivo. In vitro protein adsorption, multiplex Luminex assays, quantitative PCR, immunofluorescence analysis and RNA sequencing are additionally carried out to validate the hypothesis. We further demonstrate long-term bidirectional electrical communication enabled by implantable electrodes with an adhesive interface over 12 weeks in a rat model in vivo. These findings may offer a promising strategy for long-term anti-fibrotic implant-tissue interfaces.
FIELD: organometallic compounds. SUBSTANCE: invention proposes the use of derivatives of cis-diamminediimidazolyl platinum dichloride of the general formula given in description. Method of synthesis involves interaction of cis-diimidazole platinum dichloride with 25% ammonium an aqueous solution at heating and intensive stirring up to complete dissolving followed by cooling and isolation of the end product. Synthesized compound shows antiproliferative and cytostatic activity and can be used in medicine, pharmaceutical and chemical industry. EFFECT: improved method of synthesis, enhanced effectiveness of compound. 2 cl, 5 tbl
Myocarditis is an important public health issue due to the high prevalence of sudden death in adolescents and young adults. Nevertheless, the early identification of myocarditis remains a serious problem for clinicians. There is no single non-invasive method to diagnose myocarditis in the currently available clinical guidelines and consensus. Molecular imaging is an effective approach for accurate diagnosis. Poly(lactic acid-glycolic acid) (PLGA) is considered to be the preferred carrier for molecular imaging because of its biosafety and modifiability. Macrophage membrane-modified biomimetic nanoprobes (MM-NPs) possess low immunogenicity and inflammation-directed chemotaxis capabilities and are repeatedly chosen as materials for targeted diagnosis and treatment of inflammatory diseases. In this study, experimental autoimmune myocarditis (EAM) was used as an animal model of inflammation. Previous studies have confirmed that this model is similar to pathological injury caused by acute myocarditis in humans. In multimodal imaging (US/PA/MRI), a phase-change material (PFH) and superparamagnetic iron oxide (SPIO) are used as imaging substances. Early identification of myocardial inflammatory sites was achieved by the tail vein injection of MM/NPs loaded with PFH and SPIO. This probe is expected to be a powerful tool for clinicians to diagnose myocarditis.
The combination therapy of Carfilzomib, cyclophosphamide and dexamethasone (KCyd) will be used to treat eligible patients for up to 6 cycles.This will be followed by an autologous bone marrow transplantation and 2 further consolidation cycles of KCyd. Depending on their disease response, patients will be managed expectantly or be started on maintenance.
Subjects randomized to the control arm will receive education and a handbook on the benefits of exercise and will be encouraged to have adequate protein in their diet and provided with the list of high protein foods and nutritional information. These subjects will undergo the same assessments as the intervention arm at all time points. Control subjects will be offered a 6-week home exercise program 3 months after CRS/HIPEC. Results and outcomes will not be recorded.
Compositions for use in dry powder inhalers contain a percentage of lubricant e.g. magnesium stearate to increase the fine particle dose. The highest possible surface area of the carrier particles is coated with the lubricant in order to increase the release of the active particles and hence the respirable fraction. A powder for use in a dry powder inhaler comprises an active ingredient and a carrier. The carrier includes between 0.05 and 0.5 percentage by weight of a lubricant. The lubricant particles at least partially coat the carrier particles surface.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to ophthalmology, and can be used for the administration of preventive antibiotics in ophthalmic surgeries. That is ensured by intravenous introduction of Cefuroxime in dosage 750 mg 30 minutes before the procedure. Repeated introduction of Cefuroxime is carried out after the procedure intramuscularly in the same dosage, in 8 hours after the first introduction. In the patients with a severe accompanying pathology, introduction of the antibiotic after double introduction is continued for 5-6 days intramuscularly 3 times a day in the same dosage. ^ EFFECT: method provides effective prevention of infectious complications, including due to the penetration of Cefuroxime through the blood-aqueous barrier and the creation of required concentration of this antibiotic in a visual organ at the different stages of surgical management. ^ 1 ex
Participants are asked to train (at least) 5 times a week during 15 - 20 mins. The first 4 sessions are training sessions, the fifth session is an in-training test session (DTT and phoneme discrimination).
Chronic pain is a notable health concern because of its prevalence, persistence, and associated mental stress. Drugs targeting chronic pain with potent abirritation, and minimal side effects remain unidentified. Substantial evidence indicates that the Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a distinct and critical role in different stages of chronic pain. Aberrant activation of the JAK2/STAT3 signaling pathway is evident in multiple chronic pain models. Moreover, an increasing number of studies have demonstrated that the downregulation of JAK2/STAT3 can attenuate chronic pain in different animal models. In this review, we investigated the mechanism and role of the JAK2/STAT3 signaling pathway in modulating chronic pain. The aberrant activation of JAK2/STAT3 can trigger chronic pain by interacting with microglia and astrocytes, releasing proinflammatory cytokines, inhibiting anti-inflammatory cytokines, and regulating synaptic plasticity. We also retrospectively reviewed current reports on JAK2/STAT3 pharmacological inhibitors that demonstrated their significant therapeutic potential in different types of chronic pain. In summary, our results provide strong evidence that the JAK2/STAT3 signaling pathway is a promising therapeutic target for chronic pain.
PROBLEM TO BE SOLVED: To provide an in vivo examination means which can easily and securely examine effects of a hair growing material on extending the hair growth period in a growth cycle by applying the hair growing material to a nude mouse, specifying the condition of a part with hair growing on the body surface of the nude mouse, and examining the effects of the hair growing material on extending the hair growth period in a growth cycle. SOLUTION: In this method, such a nude mouse is used as has basically no hair but can grow hair in a part of the body surface which may move over time. Hair of the mouse (e.g. balb c nu/nu) grows in a very long and narrow part for a limited period (according to a hair growth cycle), and the grown hair will gradually fall out in a few days. As a result, the part with hair growing will move from the head to the tail of the mouse as time passes. As for such a nude mouse, the length of the growth period in a hair growth cycle can be examined by specifying the width of the part with hair growing and the speed of moving of the part with hair growing, or observing time for hair to start growing in a specific part. The hair growing material to be examined will be applied to the surface skin of the mouse, or orally administered, or hypodermically injected.
Interpersonal psychotherapy that focuses on an adolescents relationship and communication skills in the context of of their depression. After 8 weeks of therapy, participants with at less than a 40% reduction in Hamilton Rating Scale for Depression (HRSD) score will be further randomized into 2 groups, increased dose of interpersonal psychotherapy or introduction of fluoxetine therapy starting with 10 mg per day for the first week and 20 mg per day in the following 5 weeks. If HRSD scores meet target, patients continue to receive initial dose of interpersonal psychotherapy.
BACKGROUND: This study aimed to evaluate dentist perceptions of attractive smiles in the Pakistani population, considering different dental proportions.
METHODS: Maxillary casts and digital images were used to create symmetrical representations of anterior teeth. dentists' preferences for good and bad teeth proportions, width/height ratios, and various dental proportions (golden, recurring esthetic dental (RED), golden percentage, Preston, and local/observed) were assessed using one sample and paired t-test. The Chi-square test was used to determine the gender disparities and factors affecting smile attractiveness. A p-value of ≤ 0.05 was taken as significant.
RESULTS: The RED proportion emerged as the preferred choice for normal-sized teeth, with specialists and general dentists favoring it over the golden proportion. For tall teeth, the golden proportion was predominantly preferred. The golden percentage received limited preference for aesthetic smile construction.
CONCLUSIONS: The smiles created using the principles of RED proportion were opted as the most attractive by local dentists. Factors such as tooth arrangement, color, and midline were highlighted as essential considerations in aesthetic smile construction.
Group Decompression: Patients assigned to Group Decompression. After determination of the appropriate space for the approach under fluoroscopy guidance, a 17 gauge trochar needle was advanced posterolaterally up to the center of the disc. Then site verification was done again with water soluble contrast material under floroscopy guidance. Then flexible intradiscal decompression catheter (SpineCATH®, Smith \& Nephew, Memphis, TN) were advanced inside the trochar needle towards the disc and decompression was performed. After being sure of achieving sufficient decompression inside the disc, the decompression device were removed under fluoroscopy guidance and the incision site was closed and the patients were recommended to have bedrest for 2 hours.
Arm: Other: Group 1 Participants in this group will receive the culturally tailored education booklet titled "Your Guide to Sugar Diabetes". In addition, subjects will complete 10 sessions of diabetes education delivered weekly via videoconferencing lasting 60 minutes each session as detailed above.