anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Esophageal cancer, a global health concern, impacts predominantly men, particularly in Eastern Asia. Lymph node metastasis (LNM) significantly influences prognosis, and current imaging methods exhibit limitations in accurate detection. The integration of radiomics, an artificial intelligence (AI) driven approach in medical imaging, offers a transformative potential. This meta-analysis evaluates existing evidence on the accuracy of radiomics models for predicting LNM in esophageal cancer.
METHODS: We conducted a systematic review following PRISMA 2020 guidelines, searching Embase, PubMed, and Web of Science for English-language studies up to November 16, 2023. Inclusion criteria focused on preoperatively diagnosed esophageal cancer patients with radiomics predicting LNM before treatment. Exclusion criteria were applied, including non-English studies and those lacking sufficient data or separate validation cohorts. Data extraction encompassed study characteristics and radiomics technical details. Quality assessment employed modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Radiomics Quality Score (RQS) tools. Statistical analysis involved random-effects models for pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC). Heterogeneity and publication bias were assessed using Deek's test and funnel plots. Analysis was performed using Stata version 17.0 and meta-DiSc.
RESULTS: Out of 426 initially identified citations, nine studies met inclusion criteria, encompassing 719 patients. These retrospective studies utilized CT, PET, and MRI imaging modalities, predominantly conducted in China. Two studies employed deep learning-based radiomics. Quality assessment revealed acceptable QUADAS-2 scores. RQS scores ranged from 9 to 14, averaging 12.78. The diagnostic meta-analysis yielded a pooled sensitivity, specificity, and AUC of 0.72, 0.76, and 0.74, respectively, representing fair diagnostic performance. Meta-regression identified the use of combined models as a significant contributor to heterogeneity (p-value = 0.05). Other factors, such as sample size (> 75) and least absolute shrinkage and selection operator (LASSO) usage for feature extraction, showed potential influence but lacked statistical significance (0.05 < p-value < 0.10). Publication bias was not statistically significant.
CONCLUSION: Radiomics shows potential for predicting LNM in esophageal cancer, with a moderate diagnostic performance. Standardized approaches, ongoing research, and prospective validation studies are crucial for realizing its clinical applicability.
Clinically, there are localized or generalized flaccid bullae that quickly transform into post-bullous erosions and crusts , PV patients characteristically develop oral lesions with buccal and/or gingival persisting erosions (mucosal dominant PV) which several weeks or months later may also spread to the epidermis (mucocutaneous PV). PF is characterized by widespread cutaneous fragile bullae which rapidly rupture, resulting in erosions, crusting, and scaling. In contrast to PV, the mucosa is usually not involved in PV. (Zenzo .et al .,2015).

Pathophysiologically, the underlying intraepithelial blister formation is caused by IgG autoantibodies against the desmosomal adhesion proteins, desmoglein 3 and/or desmoglein 1, on epidermal keratinocytes. ( Amagai .et al .,1991) In PV the antigen is desmoglein 3 which is presented in lower epidermis and is expressed more strongly in buccal mucosa than in the skin ,in contrast to PF which its antigen is desmoglein 1 which is expressed in the skin throughout the epidermis and weakly expressed in the mucous membranes . ( Kneisel and Hertl. .,2011).

T cells play a crucial role in the pathogenesis of pemphigus vulgaris , The interaction of T and B cells critically modulates the development of pemphigus vulgaris. (Amber. et al., 2013 ; Zhu, et al.,2012).

Because B-cell activation and antibody production classically necessitate the involvement of CD4+ T cells, Dsg-reactive T cells were capable of recognizing multiple epitopes of the extracellular domain of Dsg and helping B cells to produce a specific antibody. Dsg3-reactive T-cell clones were able to commit polyclonal naive B cells to produce pathogenic anti-Dsg3 antibody and induce the PV phenotype. (Hertl . et al., 1998) Follicular T helper cells (Tfh) are a recently discovered group of CD4+ Th cells with intrinsic differences from Th1, Th2 and Th17 cells. Localized in B-cell follicles of secondary lymphoid tissues, The major function of Tfh cells appears to help B-cell activation and antibody production during humoral immune responses. The Tfh cells express high levels of IL-21, which was demonstrated to be important for the generation of Tfh cells and that responsiveness of Tfh cells to IL-21 drives the formation of the autoimmune reaction, and it clearly impacted on the amount of antibody production.( Gomez. et al.,2011 ; Vogelzang . et al.,2008) Nowadays, finding a promising treatment for pemphigus remains a serious challenge. Various treatments are currently recommended to treat this disease, but they rarely lead to complete and durable remission. Regulatory cells appear to have a critical role in numerous autoimmune diseases, so it is possible that control of these cells may induce remission. (Cholera and Chainani .,2016)
With the administration of acetylcysteine the patient may initially observe a slight disagreeable odor that is soon not noticeable. With a face mask there may be stickiness on the face after nebulization. This is easily removed by washing with water.

Under certain conditions, a color change may occur in the opened bottle of acetylcysteine. The light purple color is the result of a chemical reaction which does not significantly affect the safety or mucolytic effectiveness of acetylcysteine.

Continued nebulization of acetylcysteine solution with a dry gas will result in an increased concentration of the drug in the nebulizer because of evaporation of the solvent. Extreme concentration may impede nebulization and efficient delivery of the drug. Dilution of the nebulizing solution with appropriate amounts of Sterile Water for Injection, USP, as concentration occurs, will obviate this problem.
Provided are sphingosine kinase 1, a fusion protein comprising same, and a use thereof. The sphingosine kinase 1 and the fusion protein comprising the same have marked effects in lowering blood sugar and body weight, and are useful for the preparation of a protein drug for controlling metabolic diseases such as obesity and diabetes. Also provided is a protein drug, which is a fusion protein comprising sphingosine kinase 1 or an amino acid sequence having an activity thereof. The fusion protein comprises sphingosine kinase 1 (SPHK1) or an amino acid sequence having an activity thereof, a FC sequence and a linker sequence. The protein drug can significantly decrease blood sugar, blood fat and body weight, and improve fat metabolism. Also provided are a preparation method, an encoding gene, an expression construct and a host cell for the protein drug, and further provided are use of the protein drug, encoding gene, expression construct and host cell in the preparation of a pharmaceutical composition for preventing and/or treating obesity, hyperlipidemia or diabetes.
NEW MATERIAL:The fish growth hormone polypeptide having the peptide sequence of formula. USE:Growth-promoting agent for pisciculture. PREPARATION:For example, the frozen pituitary gland of chum salmon is solubilized by disintegrating in a solution containing guanidium thiocyanate, mixed with a solution containing cesium chloride, and subjected to the ultracentrifugation to recover the RNA as the precipitate. The RNA is passed through a column of oligo(dT)cellulose. The mRNA separated by the above process is mixed with a vector primer prepared by incising a plasmid with a restriction enzyme, and treated with a reverse transcriptase to synthesize a DNA complementary to the mRNA. The DNA is cyclized to a recombinant DNA by reacting with a linker DNA. Escherichia coli is transformed with the recombinant plasmid to the E.coli containing the DNA coding said polypeptide, and the transformed strain is cultured in a medium to produce the compound of formula.
Tumors with low levels of oxygen have been found to be more resistant to standard radiation and chemotherapy treatments. For patients with tumors with low oxygen levels, it is not well known if higher radiation doses can overcome treatment resistance to radiation. Currently, there are limited ways of measuring tumor oxygen levels. The investigators believe that measuring tumor oxygen levels during the brachytherapy procedure will allow the investigators to develop better and improved oxygen measurement techniques, and ultimately improve clinical outcomes for patients, such as better local tumor control.

This research study is a Pilot Study, meaning that this is the first time investigators are examining the oxygen sensor being used. This study is designed to test the oxygen sensor's ability to measure the oxygen levels within the participant's cervical tumor with the aid of magnetic resonance imaging (MRI) scans. MRI scans use magnets to make detailed images of the participant's tumor and the surrounding normal tissues during the brachytherapy procedure.
The invention discloses traditional Chinese medicine for treating liver cirrhosis and liver ascites. The traditional Chinese medicine is prepared from, by weight, 1-5 parts of fructus aurantii, 1-5 parts of radix geutianae, 1-5 parts of herba artemisiae capillariae, 1-3 parts of rhizoma cyperi, 1-3 parts of rhizoma sparganii, 1-3 parts of rhizoma curcumae, 1-7 parts of sticky rice, 1-7 parts of black soybean, 1-3 parts of pangolin scales and 1-3 parts of umbellate pore fungi. The invention further discloses a preparing method. The preparing method includes the following steps that 1, all raw materials by the formula ratio are smashed into powder and mixed uniformly; 2, water is added into the uniformly mixed powder, the mixture is rolled into pills, and the pills are dried to obtain the traditional Chinese medicine for treating liver cirrhosis and liver ascites. The raw materials of the traditional Chinese medicine are reasonable in compatibility and supplement each other, the traditional Chinese medicine has the effects of removing dampness, relieving abdominal fullness, clearing heat, promoting dieresis, promoting the circulation of qi, promoting urination, relaxing the bowels, expelling retained water, promoting blood circulation to remove blood stasis, dispersing the depressed liver-qi, alleviating pain and softening liver and spleen and therefore can treat liver cirrhosis and liver ascites well. The traditional Chinese medicine has the advantages of being remarkable in treatment effect, small in toxic and side effect, low in treatment cost and the like and treats both symptoms and root causes.
BACKGROUND: Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a frequent superinfection in critically ill patients with COVID-19 and is associated with increased mortality rates. The increasing proportion of severely immunocompromised patients with COVID-19 who require mechanical ventilation warrants research into the incidence and impact of CAPA during the vaccination era.
METHODS: We performed a retrospective, monocentric, observational study. We collected data from adult patients with severe COVID-19 requiring mechanical ventilation who were admitted to the intensive care unit (ICU) of University Hospitals Leuven, a tertiary referral center, between 1 March 2020 and 14 November 2022. Probable or proven CAPA was diagnosed according to the 2020 European Confederation for Medical Mycology/International Society for Human and Animal Mycology (ECMM/ISHAM) criteria.
RESULTS: We included 335 patients. Bronchoalveolar lavage sampling was performed in 300 (90%), and CAPA was diagnosed in 112 (33%). The incidence of CAPA was 62% (50 of 81 patients) in European Organisation for Research and Treatment of Cancer (EORTC)/Mycosis Study Group Education and Research Consortium (MSGERC) host factor-positive patients, compared with 24% (62 of 254) in host factor-negative patients. The incidence of CAPA was significantly higher in the vaccination era, increasing from 24% (57 of 241) in patients admitted to the ICU before October 2021 to 59% (55 of 94) in those admitted since then. Both EORTC/MSGERC host factors and ICU admission in the vaccination era were independently associated with CAPA development. CAPA remained an independent risk factor associated with mortality risk during the vaccination era.
CONCLUSIONS: The presence of EORTC/MSGERC host factors for invasive mold disease is associated with increased CAPA incidence and worse outcome parameters, and it is the main driver for the significantly higher incidence of CAPA in the vaccination era. Our findings warrant investigation of antifungal prophylaxis in critically ill patients with COVID-19.
Category B

Fertility studies have not been done. Teratology studies in rats and rabbits at doses from 0.05 to 10 mcg/kg/day (approximately 0.1 times the maximum systemic human exposure in rats and up to 38 times the maximum systemic human exposure in rabbits based on surface area, mg/m2) revealed no harm to the fetus due to desmopressin acetate. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. 

Several publications where desmopressin acetate was used in the management of diabetes insipidus during pregnancy are available; these include a few anecdotal reports of congenital anomalies and low birth weight babies. However, no causal connection between these events and desmopressin acetate has been established. A fifteen year Swedish epidemiologic study of the use of desmopressin acetate in pregnant women with diabetes insipidus found the rate of birth defects to be no greater than that in the general population; however, the statistical power of this study is low. As opposed to preparations containing natural hormones, desmopressin acetate in antidiuretic doses has no uterotonic action and the physician will have to weigh the possible therapeutic advantages against the possible risks in each case.
ETHNOPHARMACOLOGICAL RELEVANCE: Xi Yang Shen (Panax quinquefolium L.) was originally recorded in "Ben Cao Cong Xin" edited by Wu Yiluo during the Qing Dynasty. Panax Quinquefolium Saponins (PQS) is the main component derived from Panax quinquefolium L, and has been wildly used in the treatment of coronary heart disease.
AIM OF THE STUDY: This study aims to explore the potential role and underlying mechanisms of PQS in promoting angiogenesis in rats with diabetes and myocardial infarction.
MATERIALS AND METHODS: Echocardiograms were used to assess cardiac function, while the heart weight to tibia length ratio was calculated to determine cardiac hypertrophy. Hematoxylin and eosin, periodic acid-Schiff and Masson's trichrome staining were used to examine cardiac morphology, myocyte diameter, and myocardial fibrosis. Immunofluorescence staining was employed to evaluate arteriolar density. The transcriptomes were analyzed and bioinformatic analyses were conducted to predict the potential angiogenesis-promoting mechanism of PQS. In addition, RT-PCR and western blotting was utilized to examine the expression of genes and proteins influenced by PQS.
RESULTS: PQS improved blood glucose, ameliorated cardiac function, reduced cardiac hypertrophy, and enhanced myocardial morphology in diabetic rats with myocardial infarction. PQS was also found to decrease myocyte diameter, curtail myocardial fibrosis, and increase arteriolar density. However, the effects of PQS were abolished following the deletion of protein kinase C δ (PKCδ). Molecular docking predicted strong interactions between the major blood components of PQS and PKCδ. Transcriptomic and bioinformatic analyses indicated that PQS may bolster angiogenesis by activating the VEGF/PI3K-Akt/eNOS pathway in rats with diabetes and myocardial infarction. Finally, the study demonstrated that PQS could inhibit the expression of PKCδ and stimulate the activation of the VEGF/PI3K-Akt/eNOS pathway.
CONCLUSIONS: PQS improves blood glucose, enhances cardiac function, mitigates cardiac damage, and boosts arteriolar density. The angiogenic impact of PQS appears to be, at least partially, due to its modulation of the PKCδ-mediated VEGF/PI3K-Akt/eNOS signaling pathway in rats with diabetes and myocardial infarction.
The invention discloses acupuncture-combined cancer treatment vomit-stopping powder and its preparation method and use. The acupuncture-combined cancer treatment vomit-stopping powder is prepared from radix aconite lateralis preparata, dry ginger, cassia bark, poria cocos, bighead atractylodes rhizome, inula flower, fructus evodiae, ginger processed pinellia and ruddle. The preparation method comprises weighing the above traditional Chinese medicines according to a ratio, mixing the traditional Chinese medicines, chopping the traditional Chinese medicines and grinding the traditional Chinese medicines to obtain powder. The vomit-stopping powder is used for treatment on gastrointestinal tract symptoms such as nausea and vomiting after cancer chemotherapy. The drug composition and acupuncture acupoint selection are based on clinical experience. Clinical experiences in a long term prove that the vomit-stopping powder has observabe treatment effects, does not produce wound and pain, can be operated simply, can be easily accepted by patients, is safe and effective in treatment, has a wide clinical application range and is suitable for diseases of all departments.
A consent management system may receive a request to modify consent data associated with a patient. The system may obtain patient capacity information associated with the patient and may determine whether to allow the patient to modify the consent data based on the obtained patient capacity information. The patient capacity information may indicate patient cognitive capacity, patient emotional capacity and/or the like. A response to the consent modification request may be generated based on the determining. For example, based on a determination that the obtained patient capacity information indicates that patient lacks the capacity to modify the consent data, the response may indicate a rejection of the request (e.g., may indicate that the consent data may not be modified). Based on a determination that the obtained patient capacity information indicates that patient possesses the capacity to modify the consent data, the response may indicate an approval of the request.
Composition, preferably a film-shaped composition, comprises at least one active substance or its salt, at least one complexing agent for stabilizing the active substance or its salt, at least one semi-synthetic hydrophilic polymer and optionally at least one natural hydrophilic polymer. The amount of natural and semi-synthetic polymers is greater than the amount of synthetic polymers in the total composition. At least one semi-synthetic polymer and optionally at least one natural polymer are present in an amount of 30-50 wt.% total composition. Composition, preferably a film-shaped composition, comprises at least one active substance or its salt, at least one complexing agent for stabilizing the active substance or its salt, at least one semi-synthetic hydrophilic polymer and optionally at least one natural hydrophilic polymer. The amount of natural and semi-synthetic polymers is greater than the amount of synthetic polymers in the total composition. At least one semi-synthetic polymer and optionally at least one natural polymer are present in an amount of 30-50 wt.% total composition. The complexing agent is present in an amount of 10-50 wt.% total composition.
FIELD: medicine, stomatology. SUBSTANCE: the suggested preparation upon biopolymeric foundation contains the complex of biologically active substances out of sage and yarrow. Moreover, as biopolymeric foundation one should use 2%-acetic acid collagen solution and sodium alginate, and as biologically active substances it contains camomile and calendula tinctures, dog rose extract, sanguinarine and water. Components are taken at a certain quantitative ratio. The method provides higher adhesion to mucous surfaces, increased amount of medicinal preparations in affected area and improved protection of wound surface. EFFECT: improved curative results. 1 cl, 3 ex
PROBLEM TO BE SOLVED: To obtain the subject composition which gives sufficient smoothness, pliability and moistness to hair and is excellent in detergent effect for hair by mixing a specific amidoamine compound, a specific oily additive component, an organic acid and a specific surfactant. SOLUTION: This composition is prepared by blending (A) an amidoamine compound of formula I (R<1> is a residual of higher aliphatic acid; R<2> is an alkyl; (n) is 2-4), (B) an oily additive component selected from higher alcohols and higher aliphatic acids, (C) an organic acid and (D) an alkyloylalkyltaurine salt type anionic surfactant of formula II (R<3> is an alkyl and an alkenyl; R<4> is a lower alkyl; M is an alkali metal and an organic amine). The (A) component is stearic acid dimethylaminopropyl-amide and the like and is formulated in an amount of about 0.001-2.0wt.%. The (B) component is palmitic acid and the like and is formulated in a proportion of about 0.001-5.0wt.%. The (C) component is L-glutamic acid and the like and is formulated in an amount of about 0.001-5.0wt.%.  The (D) component is sodium salt of a plam aliphatic acid methyltaurine and is formulated in a proportion of about 1.0-20.0wt.%.
NEXICLON XR was studied in an open-label crossover, force titration, partially randomized trial in patients with mild and moderate essential hypertension who were on two or fewer antihypertensive medications. The trial was designed to compare steady-state exposures between the NEXICLON XR and clonidine immediate-release tablets. There were up- and down-titration phases. There was no washout period between phases or treatments.

Studies with immediate-release clonidine hydrochloride have demonstrated a moderate reduction (15% to 20%) in cardiac output in the supine position with no change in the peripheral resistance. At a 45° tilt, there is a smaller reduction in cardiac output and a decrease of peripheral resistance. During long-term therapy, cardiac output tends to return to control values, while peripheral resistance remains decreased. Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise.

Tolerance to the antihypertensive effect may develop in some patients, necessitating a re-evaluation of therapy.

Other studies in patients have provided evidence of a reduction in plasma renin activity and in the excretion of aldosterone and catecholamines. The exact relationship of these pharmacologic actions to the antihypertensive effect of clonidine has not been fully elucidated.

Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use.
Vizumax-ENEM es un sulfato de bario para suspensión 96% p / p para administración rectal. Cada 100 g contiene 96 g de sulfato de bario. El sulfato de bario, debido a su alta densidad molecular, es opaco a los rayos X y, por lo tanto, actúa como un agente de contraste positivo para estudios radiográficos. El ingrediente activo es sulfato de bario y su fórmula estructural es BaSO4. El sulfato de bario se presenta como un polvo fino, blanco, inodoro, insípido y voluminoso, libre de arenosidad. Sus suspensiones acuosas son neutrales al tornasol. Es prácticamente insoluble en agua, soluciones de ácidos y álcalis, o solventes orgánicos.