anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obstructive sleep apnea (OSA) is highly prevalent in patients with asthma. Asthma, dose-dependently to its duration, promotes incident OSA, suggesting that asthma plays a role in OSA pathogenesis. We hypothesized that asthma-related inflammation alters breathing control mechanisms, specifically the carotid chemoreflex. Accordingly, we measured hypoxic ventilatory responses (HVR) in awake, unrestrained, ovalbumin (OVA)-sensitized Brown Norway rats and compared them with responses in sham-sensitized (SALINE) controls. To differentiate the role of allergic inflammation from bronchoconstriction, we repeated hypoxic ventilatory response (HVR) after administration of formoterol, a long-acting bronchodilator. Blood and bronchoalveolar lavage (BAL) fluid were collected for quantification of inflammatory cytokines. The rise in ventilatory equivalent for O2 evoked by acute exposure to hypoxia was augmented following sensitization by OVA, whereas it remained stable after SALINE. This augmentation was driven by increased breathing frequency with no change in tidal volume. Tachypneic hyperventilation in normoxia was also observed with OVA. Neither the increased HVR nor excessive normoxic ventilation was affected by formoterol, suggesting that they were not secondary to lung mechanical constraints. Higher levels of inflammatory cytokines were observed in BAL fluid and serum of OVA versus SALINE. In OVA, serum interleukin-5 levels significantly correlated with change from baseline in ventilatory responses to severe hypoxia ([Formula: see text], 0.09). These observations are consistent with inflammation-induced enhancement of carotid chemoreflex function, i.e., increased controller gain, and they suggest a possible role for asthma-related allergic inflammation in the ventilatory instability known to promote upper airway collapse and sleep apnea in humans.NEW & NOTEWORTHY Asthma is a risk factor for obstructive sleep apnea (OSA); however, the mechanisms are incompletely understood. In a rat model of allergic inflammation associated with asthma, we found that ventilation in normoxia and ventilatory responses to hypoxia were markedly enhanced and related with systemic inflammation. These alterations indicating carotid chemoreflex sensitization, known to promote ventilatory instability during sleep in humans, may contribute to the increased OSA risk in asthma.
The present invention relates to peptides which home to cells, e.g. heart cells, with high selectivity and which can be useful in the form of compositions. Such compositions can be used, e.g., for selectively targeting a systemically administered therapeutic agent or imaging agent to a cell or tissue in a subject. The present invention further relates to methods of using the compositions for imaging, e.g. PET imaging, and targeting cells, e.g. for delivering a therapeutic agent to one or more target cells in a subject.
PROBLEM TO BE SOLVED: To obtain a humectant having remarkable roughened skin-improving effect and excellent in moisture retention, smoothness and anti-sticking property of skin surface by using a specific component derived from soybean as an active ingredient. SOLUTION: This humectant comprises a component obtained by subjecting soybean component to enzymatic treatment. Bean-curd refuse is preferably used as the soybean component. An enzyme having action decomposing soybean cell wall, especially cellulase, hemilase or glucanase is preferably used as the enzyme. The humectant is obtained by adding water to soybean component, reacting the soybean component with the enzyme under active conditions to afford an enzymatically treated mixture and then, deactivating the enzyme. The humectant can be utilized for skin lotion, milk lotion, cream, lotion, essence, pack, bathing agent, foundation, etc.
MicroRNAs (miRNAs) in oral squamous cell carcinoma (OSCC)-derived small extracellular vesicles (sEVs) play a pivotal role in modulating intercellular communications between tumor cells and other cells in the microenvironment, thereby influencing tumor progression and the efficacy of therapeutic interventions. However, a comprehensive inventory of these secretory miRNAs in sEVs and their biological and clinical implications remains elusive. This study aims to profile the miRNA content of OSCC cell line sEVs and computationally elucidate their biological and clinical relevance. We conducted miRNA sequencing to compare the miRNA profiles of OSCC cells and their corresponding sEVs. Our motif enrichment analysis identified specific sorting motifs that are implicated in either cellular retention or preferential sEV secretion. Target cell analysis suggested that the sEV miRNAs potentially interact with various immune cell types, including natural killer cells and dendritic cells. Additionally, we explored the clinical relevance of these miRNAs by correlating their expression levels with TNM stages and patient survival outcomes. Intriguingly, our findings revealed that a distinct sEV miRNA signature is associated with lymph node metastasis and poorer survival in patients in TCGA-HNSC dataset. Collectively, this research furthers our understanding of the miRNA sorting mechanisms in OSCC and underscores their clinical implications.
The interval between each exercise session will be one week. Prior each to the exercises sessions (4), volunteers will undergo specific warm-up in each exercise adopted (a series of 15 repetitions with 40% of the maximum load obtained in the 10RM test). The exercise sessions will consist of four sets for 10RM, with an interval of one minute between sets and two minutes between exercises. The exercise sequence (extension chair, squat and leg press) will be randomized through a closed brown envelope draw. Prior to the 10RM test and data collection, standardized instructions regarding the experimental procedure and exercise technique will be provided. Verbal stimuli to the volunteer will be performed during the evaluations and exercises (TEIXEIRA et al., 2014a, 2014b). Volunteers will undergo an FR session immediately after resistance exercise session (PEARCEY et al., 2015).
Beginning at least 6 weeks post-stem cell transplant, patients receive nivolumab IV over 60 minutes on days 1 and 15. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
THe aim of this study is to Determine how age, sex, and adiposity influence the accuracy of EE determined from measurements of total heat production . This will be a randomized study with two within subject conditions(high and low physical activity levels). A heterogenous sample of adult men and women in stable health will be studied. We will study subjects across a wide range of weight (up to 300 lbs) and age range (≥ 18 yrs).
The long-term objective of this research is to improve patient understanding of the known and strongly suspected risks from treating infertility with assisted reproductive technologies such as in vitro fertilization (IVF). During IVF, when more embryos are transferred to the uterus, the risk of pregnancy with multiple fetuses increases. In addition, single infants conceived with IVF are at greater risk for low birth weight. This study will promote behaviors that may reduce these risks. One in 3 women who completes a pregnancy conceived with assisted reproductive technologies such as IVF delivers multiples, and these treatments produce over 12,000 multiple birth deliveries annually in the United States. This study will lead to a better understanding of the most effective ways to counsel IVF patients about the embryo transfer decision. This study will also help define how to prepare IVF patients to work most effectively with their prenatal care team to manage IVF-related obstetrical risks.

Medical Treatment Coverage: None, this study does not provide any monetary contribution to medical treatment
Patients receive Akt inhibitor MK2206 PO once per week on weeks 1-44 and bicalutamide PO QD on weeks 13-44. Patients with a PSA decline of \>= 50% may continue on Akt inhibitor MK2206 and bicalutamide until week 72 in the absence of disease progression or unacceptable toxicity.
BACKGROUND: Metabolic bariatric surgery (MBS) is standardized and safe. Nevertheless, complications such as anastomotic leakage (AL) or staple-line leakage (SLL) can occur. In upper GI or colorectal surgery, endoluminal vacuum therapy (EVT) offers a therapeutic alternative to revisional surgery. Data on EVT in patients with leakage after MBS remain scarce. The aim of this study is to evaluate the efficacy of EVT and its potential as endoscopic alternative to revisional surgery.
MATERIAL AND METHODS: All patients treated for AL or SLL with EVT after MBS between 01/2016 and 08/2023 at the Department for General Surgery, Medical University Vienna, were included in this retrospective, single-center study. Therapeutic value of EVT as management option for acute postoperative leakage after MBS in daily practice was evaluated. Statistical analyses were performed descriptively.
RESULTS: Twenty-one patients were treated with EVT within the observational period of 7 years. In 11 cases (52.4%), the index surgery was a primary bariatric intervention; in 10 cases (47.6%), a secondary surgery after initial MBS was performed. Favored approach was a combination of revisional surgery and EVT (n = 18; 85.7%), intermediate self-expanding metal stent (SEMS) in 16 (76.2%) cases. EVT was changed six times (0-33) every 3-4 days. Mean EVT time was 25.1 days (3-97). No severe associated complications were detected and EVT showed an efficacy of 95.2%.
CONCLUSION: This small case series supports the trend to establish EVT in daily clinical practice when revisional surgery after MBS is needed, thus preventing further reoperation and reducing associated morbidity and mortality in critically ill patients.
Sham group receives five sessions of sham low intensity extracorporeal shockwave treatment, once per week for five consecutive weeks. Treatment is initiated three weeks after radical prostatectomy and is given using DUOLITH® SD1 manufactured by STORZ MEDICAL AG with a shockwave absorbing adapter.
Participants will receive 6 weeks of the nicotine patch therapy and brief counseling sessions. Participants will also receive mindfulness strategies for 10 days during both the pre- and post-quit periods via smartphone to aid in their cessation attempt. AutoSense will be worn to detect stress and lapse throughout the 10 day period.
The present invention relates to a method for producing Ficus erecta var. sieboldii tea with improved immune-promoting activity, which comprises the step of: (a) steaming Ficus erecta var. sieboldii leaves at a temperature of 90℃ or higher; (b) crushing and forming the Ficus erecta var. sieboldii leaves into a predetermined size; (c) drying the Ficus erecta var. sieboldii leaves at a temperature of 40℃ or higher; and (d) heating the dried Ficus erecta var. sieboldii leaves at a high temperature of 130℃ or higher.
A biotin and biotin polyethylene glycol-linked GLP-1 derivative is provided to be usefully used for preventing or treating diseases caused by excessive secretion of insulin, lowering of glucose in plasma, inhibition of stomach or intestine motion, inhibition of an empty stomach or intestine, or inhibition of food intake, type 2 diabetes, obesity and irritable colon syndrome. A GLP-1 derivative in which biotin and biotin-polyethylene glycol are selectively linked to No. 26 lysine residue and No. 34 lysine residue is represented by the formula(2), wherein the biotin-polyethylene glycol is represented by the formula(1) having a molecular weight of 3,400. A method for preparing the GLP-1 derivative comprises the steps of: (a) adding biotin, biotin-polyethylene glycol and GLP to a buffer solution and an organic solvent to be subject to reaction; (b) storing the reaction mixture obtained from the step(a) under a certain temperature for a certain period of time; (c) removing non-reacted reaction products after the reaction completion of the step(b); and (d) isolating GLP-1 in which the biotin and biotin-polyethylene glycol are linked from the non-reacted products-removed products and purifying them. A pharmaceutical composition for preventing or treating diabetes or obesity comprises the biotin and biotin polyethylene glycol-linked GLP-1 derivative.
BACKGROUND: Acute kidney injury (AKI) is a critical complication of immune checkpoint inhibitor therapy. Since the etiology of AKI in patients undergoing cancer therapy varies, clarifying underlying causes in individual cases is critical for optimal cancer treatment. Although it is essential to individually analyze immune checkpoint inhibitor-treated patients for underlying pathologies for each AKI episode, these analyses have not been realized. Herein, we aimed to individually clarify the underlying causes of AKI in immune checkpoint inhibitor-treated patients using a new clustering approach with Shapley Additive exPlanations (SHAP).
METHODS: We developed a gradient-boosting decision tree-based machine learning model continuously predicting AKI within 7 days, using the medical records of 616 immune checkpoint inhibitor-treated patients. The temporal changes in individual predictive reasoning in AKI prediction models represented the key features contributing to each AKI prediction and clustered AKI patients based on the features with high predictive contribution quantified in time series by SHAP. We searched for common clinical backgrounds of AKI patients in each cluster, compared with annotation by three nephrologists.
RESULTS: One hundred and twelve patients (18.2%) had at least one AKI episode. They were clustered per the key feature, and their SHAP value patterns, and the nephrologists assessed the clusters' clinical relevance. Receiver operating characteristic analysis revealed that the area under the curve was 0.880. Patients with AKI were categorized into four clusters with significant prognostic differences (p = 0.010). The leading causes of AKI for each cluster, such as hypovolemia, drug-related, and cancer cachexia, were all clinically interpretable, which conventional approaches cannot obtain.
CONCLUSION: Our results suggest that the clustering method of individual predictive reasoning in machine learning models can be applied to infer clinically critical factors for developing each episode of AKI among patients with multiple AKI risk factors, such as immune checkpoint inhibitor-treated patients.
Glaucoma is a progressive optic neuropathy and is the leading cause of preventable irreversible blindness worldwide. Glaucoma causes progressive visual field loss and can have significant implications on the patient's quality of life. Lowering intraocular pressure (IOP) is the only treatment proven to prevent vision loss from glaucoma. It is achieved using medication, laser treatment and surgery. The treatment paradigm of glaucoma has been one whereby surgical intervention has been left for advanced cases due to a variety of reasons, mainly concerning safety and long term success. The past two decades have seen a paradigm shift towards earlier IOP lowering interventions using a wide array of different technologies in the laser and surgical spaces. This review aims to understand the background to this paradigm shift, its necessity, and its potential impact on the vision and life of glaucoma patients.
Certain embodiments present a system for generating a medical teaching file message. An image identifier labels medical images based upon information pertaining to user interaction with the image. The system also provides an image search engine that scans and indexes images within a database based on a set of rules. The image search engine generates a subset of images from a larger group of medical images within a database based upon the rules. The system also includes a supporting data selection engine for accepting a free text search query from an interface. The supporting data selection engine scans medical databases based on the free text search query, and provides the supporting data search results via an interface. A teaching file message is generated either automatically or manually from the subset of images and the supporting data search results for transmission to a teaching file.
PURPOSE: To propose an automated approach for detecting and classifying Intracranial Hemorrhages (ICH) directly from sinograms using a deep learning framework. This method is proposed to overcome the limitations of the conventional diagnosis by eliminating the time-consuming reconstruction step and minimizing the potential noise and artifacts that can occur during the Computed Tomography (CT) reconstruction process.
METHODS: This study proposes a two-stage automated approach for detecting and classifying ICH from sinograms using a deep learning framework. The first stage of the framework is Intensity Transformed Sinogram Sythesizer, which synthesizes sinograms that are equivalent to the intensity-transformed CT images. The second stage comprises of a cascaded Convolutional Neural Network-Recurrent Neural Network (CNN-RNN) model that detects and classifies hemorrhages from the synthesized sinograms. The CNN module extracts high-level features from each input sinogram, while the RNN module provides spatial correlation of the neighborhood regions in the sinograms. The proposed method was evaluated on a publicly available RSNA dataset consisting of a large sample size of 8652 patients.
RESULTS: The results showed that the proposed method had a notable improvement as high as 27% in patient-wise accuracies when compared to state-of-the-art methods like ResNext-101, Inception-v3 and Vision Transformer. Furthermore, the sinogram-based approach was found to be more robust to noise and offset errors in comparison to CT image-based approaches. The proposed model was also subjected to a multi-label classification analysis to determine the hemorrhage type from a given sinogram. The learning patterns of the proposed model were also examined for explainability using the activation maps.
CONCLUSION: The proposed sinogram-based approach can provide an accurate and efficient diagnosis of ICH without the need for the time-consuming reconstruction step and can potentially overcome the limitations of CT image-based approaches. The results show promising outcomes for the use of sinogram-based approaches in detecting hemorrhages, and further research can explore the potential of this approach in clinical settings.
For traditional MLS under general anesthesia, after general anesthesia and intubation with microlaryngeal tube, the patient would be positioned on head-ring support for better alignment and access to glottis. A laryngoscope will be inserted transorally under direct vision and suspended. Vocal cord cysts are visualized with microscope, and removed with microsurgery instruments with microflap technique and sent for routine section. After the surgery, the patient is kept nil-by-mouth until fully awake, and is discharged on same day or the next day depending on the post- operative recovery. Patient will be discharged with voice rest for 3 days.
BACKGROUND: Disease can drastically impair common bean (Phaseolus vulgaris L.) production. Anthracnose, caused by the fungal pathogen Colletotrichum lindemuthianum (Sacc. and Magnus) Briosi and Cavara, is one of the diseases that are widespread and cause serious economic loss in common bean.
RESULTS: Transcriptome analysis of the early response of common bean to anthracnose was performed using two resistant genotypes, Hongyundou and Honghuayundou, and one susceptible genotype, Jingdou. A total of 9,825 differentially expressed genes (DEGs) responding to pathogen infection and anthracnose resistance were identified by differential expression analysis. By using weighted gene coexpression network analysis (WGCNA), 2,051 DEGs were found to be associated with two resistance-related modules. Among them, 463 DEGs related to anthracnose resistance were considered resistance-related candidate genes. Nineteen candidate genes were coexpressed with three resistance genes, Phvul.001G243600, Phvul.001G243700 and Phvul.001G243800. To further identify resistance genes, 46 candidate genes were selected for experimental validation using salicylic acid (SA) and methyl jasmonate (MeJA). The results indicated that 38 candidate genes that responded to SA/MeJA treatment may be involved in anthracnose resistance in common bean.
CONCLUSIONS: This study identified 38 resistance-related candidate genes involved in the early response of common bean, and 19 resistance-related candidate genes were coexpressed with anthracnose resistance genes. This study identified putative resistance genes for further resistance genetic investigation and provides an important reference for anthracnose resistance breeding in common bean.
Specified derivatives of paraphenylenediamine and their addition salts and of para-nitroaniline, their use in hair dyeing compositions and the compositions themselves. The derivatives of paraphenylenediamine are of formula (I) R 1H, 1-8C hydrocarbon chain in which one or more carbon atoms may be replaced by one or more of O or N or Si or S or SO 2; n : 1-4; R 2, R' 2alkyl non- substituted or substituted with one or more carboxyl or alkylcarbonyl or alkoxycarbonyl or carbamoyl or mono- or dialkylcarbamoyl or heterocyclics with 4-7 atoms where the heteroatoms are N or O or S, CH 2R; R : alkyl substituted with one or more hydroxy or alkoxy or hydrogenothio or halogeno or amino or mono- or dialkylamino or amine substituted by alkylcarbonyl or carbamyl or alkylsulfonyl, aryl, benzyl; R 3H, alkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkylcarbonyl, hydroxyalkoxyalkyl, amino optionally mono or disubstituted with alkyl or acetyl or hydroxyalkyl, mono- or dialkylamino, aminoalkyl optionally mono- or disubstituted on the amine with alkyl, acetyl or hydroxyalkyl, hydroxy and amino alkyl, carboxyl, carboxyalkyl, carbamoyl, carbamoalkyl, alkoxycarbonyl, mono- or dialkylaminocarbonyl, mono- or dialkylaminocarbonylalkyl; R 4alkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, hydroxyalkoxyalkyl, aminoalkyl optionally mono- or disubstituted on the amine with alkyl or acetyl or hydroxyalkyl, hydroxy- and aminoalkyl, carboxyl, carboxyalkyl, carbamoyl, carbamoylalkyl, alkoxycarbonyl, mono- or dialkylaminocarbonyl, mono- or dialkylaminocarbonylalkyl; m : 0-4; X ->a counter ion; R 1 does not comprise a peroxide bond nor diazo, nitro or nitroso radicals. The para-nitroaniline derivatives are of formula (II); The paraphenylenediamine derivative substituted with a diazacyclohexane group and of Formula (I) n, m : 0; R 2, R' 2methyl. and 4-(4-nitrophenyl)-1,1- dimethylpiperazin-1-ium are both specifically excluded from the claim. Independent claims are included for: (1) a method of dyeing keratinic fibers by applying the composition in the presence of an oxidant for a sufficient time to develop the desired color; (2) a device comprising several compartments, one of which contains the claimed composition and another the oxidant. [Image].
PRP is freshly isolated from patients with diminished ovarian reserve as determined by at least one prior IVF cycle canceled for poor follicular recruitment response, or estimated by serum AMH and/or FSH, no menses for ≥1 year. Immediately following substrate isolation and activation with calcium gluconate, approximately 5 mL of autologous PRP is injected into each ovary under direct transvaginal sonogram guidance. AMH, FSH, and serum estradiol data will be recorded at 2wk intervals post-PRP and compared to baseline (pre-PRP) values.
The total volume of 0.5 mL was administered intranasally with a spray applicator (approximately 0.25 mL into each nostril). Each dose contained approximately 10 to 7th TCID 50 (median tissue culture infectious dose) of each of three influenza virus strains. During the 2005 enrollment period, the three 2004/2005 influenza virus strains were used: A/New Caledonia/20/99(H1N1), A/Wyoming/03/2003(H3N2), and B/Jilin/20/2003). During the 2006 and 2007 enrollment periods, the three 2005/2006 influenza virus strains were used: A/New Caledonia/20/99(H1N1), A/California/7/2004(H3N2), and B/Jiangsu/10/2003 (B/Shanghai/361/2002-like.