anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Last responders constitute an occupational category that includes all those who are involved in the postmortem care of deceased persons and their families. The work of last responders is often considered "dirty work" and, as a result, stigmatized. Last responders are aware of this stigma, and stigma consciousness has been associated with negative health outcomes. Despite the wide acknowledgment of stigma among last responders, specific risk, or protective factors for experiencing stigma have not been investigated. This paper aims to identify determinants of stigma among last responders in the United States. The data for this study were obtained from a national cross-sectional survey of last responders. The survey included a measure of stigma and multiple sociodemographic characteristics. A hurdle model was used to assess the association between the characteristics of last responders and their perceived stigma. Respondents were predominantly male (55.1%), White non-Hispanic (90.2%), and employed full-time (96%). Seventy-seven percent reported having experienced at least one form of occupation-related stigma. There was no significant association between the experience of stigma and any socio-demographic variables. The experience of stigma is nearly ubiquitous among last responders->75% of last responders in the sample experienced at least one form of stigma. Another aspect of its ubiquitous nature is the lack of evidence that stigma was experienced differentially across sex, race/ethnicity, employment type, and length of years as a last responder. Interventions are needed to decrease stigma among last responders and to support last responders in managing the consequences of the stigma they experience.
Participants will receive idelalisib for 96 weeks and obinutuzumab over 21 weeks. Following 4 weeks of treatment, safety data will be reviewed by an independent data monitoring committee (DMC). If acceptable tolerability is observed, the randomized portion of the study will begin.
PROBLEM TO BE SOLVED: To obtain the subject conjugate to which (i) a polypeptide having an affinity to HIV surface protein and HIV host target cell surface protein and (ii) a reverse transcriptase inhibitor or an HIV protease inhibitor is linked, and which has low toxicity and high anti-HIV activity. SOLUTION: This conjugate, which is useful as an anti-HIV agent or the like having low toxicity and high activity, is obtained by chemically linking one or more reverse transcriptase inhibitor(s) and/or an HIV protease inhibitor to a peptide having an affinity to HIV surface protein gp120 and/or HIV host target cell surface protein CD4, shown by formula I [A1 is H, or lysine, arginine, or ornithine residue, etc.; A2 is tyrosine or phenylalanine residue, etc.; A3 is lysine or ornithine residue; A4 is lysine or arginine residue, etc.; A5 is OH or NH2 ; Y is a peptide residue shown by formula II (A6 is alanine or valine residue, etc.; A7 is tyrosine or phenylalanine residue, etc.); Cys in positions 3 and 11 can be linked each other by the S-S bond].
Interest in microalgae products for use in food is increasing, as demands for sustainable and cost-effective food choices grow due to the escalating global population and increase in climate-related struggles with agriculture. Toxicological assessments of some species of microalgae have been conducted, but there were little data available for the oral consumption of the red microalgae Porphyridium purpureum and no data on genotoxicity. This article articulates a genotoxicity assessment and a 90-day repeated dose oral toxicity study in rats performed according to OECD guidelines. Under the experimental conditions applied, the test item did not induce gene mutations by base pair changes or frameshifts in the genome of the strains used in the bacterial reverse mutation test. Similarly, the test item did not induce structural chromosomal aberrations in V79 hamster lung cells. The test item also did not cause chromosomal damage in bone marrow of mice in the mammalian micronucleus test. The no observed adverse effect level (NOAEL) of the 90-day repeated dose oral toxicity study in rats was determined to be the highest dose tested, 3000 mg/kg bw/day. These data add to the body of evidence regarding the safety of P. purpureum for human consumption.
CR group were educated by a dietitian to reduce their usual energy intake to 1400 kcal/day (-500 kcal/day, -26% from baseline) for weight reduction and the recommended macronutrient composition was the 50-55% of energy intake as carbohydrate, 15-20% as protein and 20-25% as fat. Daily energy intake and nutrient composition were determined using a computer-aided nutritional analysis program (CAN-Pro 3.0; Korean Nutrition Society, Seoul, South Korea).
A solid form medicament is coated or bound with a water-insoluble amphoteric film-forming copolymer of (A) a vinylpyridine or an alkyl-substituted vinylpyridine and (B) acrylic or methacrylic acid and, if desired, (C) methyl acrylate, acrylonitrile, vinyl acetate, methyl methacrylate or styrene.  The medicament may be treated by applying to compressed units of it a solution in a volatile organic solvent of the copolymer, and then subjecting the compressed units to drying conditions. Alternatively, the medicament may be admixed with a solution in a volatile organic solvent of the copolymer, and then shaped, dried and pressed.  Specified solvents for the copolymers are lower alkanols, acetone and low boiling chlorinated hydrocarbons, e.g. chloroform.  Vinylpyridines specified are 2-vinylpyridine, 4-vinylpyridine, 2-methyl - 5 - vinylpyridine and 5 - ethyl - 2-vinylpyridine.  The solid medicament, which may be in the form of tablets, pills or granules, may be an antibiotic or vitamin, e.g. riboflavin.
N6-methyladenosine (m6A) serves as the most abundant posttranscription modification. However, the role of m6A in tumorigenesis and chemotherapeutic drugs sensitivity remains largely unclear. Present research focuses on the potential function of the m6A writer KIAA1429 in tumor development and sorafenib sensitivity in liver cancer. We found that the level of KIAA1429 was significantly elevated in liver cancer tissues and cells and was closely associated with poorer prognosis. Functionally, KIAA1429 promoted the proliferation and Warburg effect of liver cancer cells in vitro and in vivo. RNA-seq and MeRIP-seq analysis revealed the glycolysis was one of the most affected pathways by KIAA1429, and m6A-modified HK1 was the most likely targeted gene to regulate the Warburg effect. KIAA1429 depletion decreased Warburg effect and increased sorafenib sensitivity in liver cancer. Mechanistically, KIAA1429 could affect the m6A level of HK1 mRNA through directly binding with it. Moreover, KIAA1429 cooperated with the m6A reader HuR to enhance HK1 mRNA stability, thereby upregulating its expression. These findings demonstrated that KIAA1429/HK1 axis decreases the sensitivity of liver cancer cells to sorafenib by regulating the Warburg effect, which may provide a novel therapeutic target for liver cancer treatment.
For Group A, VAC dressing was placed to secure split thickness skin graft. Two sheets of sterilized VAC sponge that was cut to fit the wound contour were placed with a fenestrated tube between the two layers that was secured to the surrounding skin using tincture of benzoin spray and an adhesive dressing (OPSITE). The VAC was placed to intermittent -125 mmHg suction for 2 hours and then decompressed for next 2 hours.
Provides a compound Caffarolide A, a pharmaceutical composition thereof and application thereof in pharmacy, and belongs to the technical field of medical foods. The preparation method of the compound Caffarolide A has the advantages of easily available raw materials, easy operation and high yield, and is suitable for industrial production. The pharmaceutical composition taking the compound Caffarolide A as an active ingredient provides a product with better medicinal effect for a new lipid-lowering medicament. From the cell viability assay results, cafarolide a still showed no cytotoxicity at a concentration of 100 μm, indicating that it has a broad activity window. At a concentration of 40 μm, the lipid droplets had disappeared significantly with little residue. The compound Caffarolide A can be applied to preparing 3T3-L1 preadipocyte lipid inhibition active agents and lipid-lowering medicaments and medicaments for treating obesity diseases, and can be used for preparing lipid-lowering healthy products.
This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a modified viral composition that includes a moiety that binds to a cell surface receptor ligand. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy. Also provided are pharmaceutical compositions and kits including a modified viral composition.
First, the subjects will have 1 baseline day in the upright body position. This will be followed by 28 hours of head down tilt body position and air with 0.5% carbon dioxide, followed by 2 hour exposure of 3% carbon dioxide inhalation.
The invention discloses a parasite-expelling powder. The parasite-expelling powder is characterized in that selected traditional Chinese raw materials comprise costus root, betel nut, dried ginger, mume fruit, rhubarb rhizome, hawthorn fruit, cyrtomium rhizome, fructus ulmi macrocarpae, stemona root, sweet wormwood and radix lateralis aconiti carmichaeli praeparata. To achieve a better use effect, the invention also provides a preparation method for the traditional Chinese medicine powder. The preparation method comprises the following steps of (1) removing impurities from the raw materials of costus root, betel nut, dried ginger, mume fruit, rhubarb rhizome, hawthorn fruit, cyrtomium rhizome, fructus ulmi macrocarpae, stemona root, sweet wormwood and radix lateralis aconiti carmichaeli praeparata, washing with cold boiled water rapidly and draining off; and (2) drying the raw materials obtained by the step (1) in the sun and grinding into fine powder for use. The selected raw materials are complementary in medicine properties and efficacy, evades the selection of mutual inhibition, mutual resistance and mutual detoxication among the medicines, enhances mutual promotion and mutual assistance of the medicines, and has the functions of drying dampness and killing parasites, clearing heat, cooling blood and diminishing inflammation. The parasite-expelling powder has a definite curative effect for treating bovine gastrointestinal parasitic diseases.
Rapid and severe onset of middle ear infection is a common bacterial infection in children. These infections, particularly when they occur early in life and are recurrent, are associated with considerable disease and can lead to increasingly serious infections. This is a multicenter study to determine the effectiveness of levofloxacin in eliminating bacteria in the middle ear fluid of children between 6 months and 5 years of age with a rapid and severe onset of infection and inflammation of the middle ear (who are at high risk for infections that are difficult to treat). The study consists of a 1-day screening period when patients will be tested for eligibility for the study; a 4 to 6-day treatment, blood collection, possible collection of fluid from the middle ear, and assessment period; and a post-treatment period to assess the status of the middle ear infection. All patients will receive levofloxacin 2 times daily (up to a maximum daily dose of 500 mg) mixed with liquid and taken by mouth for 10 days. Safety evaluations will include laboratory tests, physical examinations, vital sign measurements, and recording of adverse events, including any report of joint pain or signs and symptoms of joint disease. Effectiveness will be assessed by the rate of elimination of the bacteria identified at the start of the study and by signs and symptoms, as well as microscopic evidence that the patient is cured of the middle ear infection. The study hypothesis is that levofloxacin will be effective in eliminating bacteria in the middle ear fluid of children with a rapid and severe onset of infection and inflammation of the middle ear and who are at high risk for infections that are difficult to treat. Levofloxacin 10 milligrams/kilogram (mg/kg) 2 times daily (up to a maximum daily dose of 500 mg) mixed with liquid and taken by mouth for 10 days
Participants will receive AZD0328 capsules for oral administration.AZD0328 is a selective α7 nicotinic receptor agonist, The total daily dosage of AZD0328 is 1mg per day; administered as 0.5mg twice daily / BID. The study treatment period is 12-weeks.
BACKGROUND/AIM: The underlying processes of renal cell carcinoma (RCC), one of the deadliest malignancies of the urinary system, are still poorly understood. HECT domain E3 ubiquitin protein ligase 2 (HECTD2) is an E3 ubiquitin ligase implicated in the pulmonary inflammatory response. This study investigated the impact of HECTD2 on regulating inflammation in RCC cells and its potential mechanisms.
MATERIALS AND METHODS: HECTD2 expression in RCC tissues was examined. Immunoprecipitation and western blot (WB) analysis confirmed that HECTD2 up-regulated euchromatic histone lysine methyltransferase 2 (EHMT2) protein degradation. ChIP experiments validated tumor necrosis factor α Inducing protein 1 (TNFAIP1) as a direct target of EHMT2. qRT-PCR determined HECTD2 and TNFAIP1 expression in RCC cells. Cell viability was assayed via CCK-8. ELISA was employed to measure the expression of IL-6, TNF-α, IL-8, and IL-1β. WB analysis was conducted to test p38/JNK pathway-related protein (p38, p-p38, JNK, and p-JNK) expression.
RESULTS: HECTD2 and TNFAIP1 were significantly up-regulated in RCC patient tissues and cells. Subsequent investigations revealed that HECTD2 promoted an inflammatory response in RCC cells. Additionally, HECTD2 up-regulated TNFAIP1 expression, and high TNFAIP1 expression could reverse the repressive impact of low HECTD2 expression on the inflammatory response in RCC cells. Rescue experiments demonstrated that the addition of p38/JNK pathway inhibitors attenuated the impact of TNFAIP1 overexpression on the RCC inflammatory response.
CONCLUSION: Our findings establish a new mechanism by which HECTD2 exerts a pro-inflammatory role in RCC cells and present a prospective method for an anti-inflammatory intervention targeting the HECTD2/TNFAIP1 axis in malignancies.
Management of Comtan overdose is symptomatic; there is no known antidote to Comtan. Hospitalization is advised, and general supportive care is indicated. There is no experience with hemodialysis or hemoperfusion, but these procedures are unlikely to be of benefit, because Comtan is highly bound to plasma proteins. An immediate gastric lavage and repeated doses of charcoal over time may hasten the elimination of Comtan by decreasing its absorption and reabsorption from the gastrointestinal (GI) tract. The adequacy of the respiratory and circulatory systems should be carefully monitored and appropriate supportive measures employed. The possibility of drug interactions, especially with catechol-structured drugs, should be borne in mind.
PURPOSE:To obtain an artificial root of teeth having excellent mechanical strength and excellent affinity for organism, consisting of a parent part made of high-strength structural material such as ceramic, metal, etc., and a dental neck part made of a biologically active material such as appetite, tricalcium phosphate, bio-glass, etc. CONSTITUTION:An artificial root of teeth consisting of a parent part 1 made of high-strength structural material such as ceramic (e.g., alumina, zirconia, carbon or silicon nitride), metal (e.g., stainless steel, titanium, titanium alloy or shape memory alloy), etc., and a dental neck part 2 made of a biologically active material such as apatite, tricalcium phosphate, bio-glass. etc. The dental neck part 2 is circularly set only in part to be brought into contact with gum when the artificial root of teeth is fixed to pyramid. Since the artificial root of teeth has high strength, a shape thereof can be made thin, implanting treatment is simplified and the artificial root of teeth can be applied to a foretooth. The figure II is an example wherein the dental neck part is detachably screwed to the parent part.
Fifteen lean \[BMI(body mass index) less than 23 kg/m2\] type 2 diabetes subjects and fifteen obese (BMI more than 26 kg/m2) subjects with type 2 diabetes treated by diet and/or metformin, SU(sulfonylurea), DPP4-inhibitors(Dipeptidyl peptidase-4 inhibitor) will be recruited. Every subject will be studied on 2 separate days in random order with 1-2 week intervals. These participants will be injected either normal saline or 10 mcg of lixisenatide in a cross-over fashion. Neuroimaging composed with resting-12-min, visual stimulation task-12-min, T1-5-min, and diffusion tensor image-12-min will be proceeded. Ad lib buffet will be provided to every participant and the intake will be measured. Surveys about appetite and mood will be done before and after neuroimaging test and buffet eating.
Allogeneic Stem Cell Transplantation With Rituximab Containing Nonablative Conditioning Regimen: Cyclophosphamide 750 mg/m\^2 given intravenously on Day -3, 4 hours after completion of Fludarabine 30 mg/m\^2 given intravenously on Days -5 and -3 before transplantation. Rituximab 375 mg/m\^2 given intravenously on Days -13, -6 before transplantation and Days 16, 8 after transplantation.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivative of 1-[ω-(3,4-dihydro-2-naphthalinyl)alkyl]cyclic amine of the formula (I) ω where values  , p, q are given in p. 1 of the invention claim. Compounds show strong inhibitory effect of the vesical reflex and are useful agents for treatment of patients suffering with often urination and enuresis. Invention describes also a pharmaceutical composition based on compounds of the formula (I). EFFECT: new compounds indicated above, high an antidiuretic potency. 11 cl, 9 tbl, 76 ex
Compounds include at least one cyclic cell penetrating peptide (cCPP) conjugated to an antisense compound (AC). The AC modulates splicing of an RNA transcript. For example, the AC induces exon skipping. Exon skipping can result in downregulation of expression or activity of a protein. Exon skipping may cause a frameshift in a resulting mRNA. The frameshift may result in a premature termination codon. The frameshift may result in nonsense mediated decay.
The method for preventing the inflammatory diseases of the internal genital organs in the women employing intrauterine contraceptive devices comprisesthe diagnostic examination prior to the insertion of the intrauterine contraceptive devices, the sexually infections being looked for. In case of such infections, complex etiopathogenic treatment is provided. The intramuscular injections of Cycloferon are prescribed. Starting from the third Cycloferon injection, Vilprafen and Metronidasol are prescribed. Starting from the third day of antibiotic treatment, antimycotic drugs are prescribed. For sanitization purposes, Miramistine is used in the swabs. After Vilprafen, Levofloxacin is prescribed. Finally, endovaginal swabs with Cycloferon liniment are employed.
Participants first received 24IU of Oxytocin administered intranasally with 6 total sprays (three in each nostril) on the morning and at midday of one study visit. Then, after at least month the participants returned for a second study day and received placebo.
PURPOSE:To obtain the titled cream having high operating efficiency, by dispersing polyoxyethylene lanolin ether in water or an alcohol with a specific dispersing agent, adding polyvinyl alcohol, glycerol and ethanol further thereto, and stirring uniformly the resultant mixture. CONSTITUTION:A hand cream as a substitute for gloves prepared by dispersing polyoxyethylene lanolin ether as a main component in water or an alcohol with coconut oil fatty acid diethanolamide, sodium lauryl sulfate or lauryl sulfate triethanolamine as a dispersing agent, adding an aqueous solution of polyvinyl alcohol and glycerol thereto to soften the resultant dried film, adding an adequate amount of ethanol, and stirring the resultant mixture. The above-mentioned hand cream is capable of forming a thin film simply by rubbing the cream in the hand before work, and drying the film. There is no sense of incompatibility on the hand surface without slipping on the surface. A small amount of the cream to be used is sufficient and economical. The cream can be washed off with water, and used with ease.
The invention relates to a Chinese herbal medicine preparation, and in particular relates to a Chinese herbal medicinal toxin-expelling powder which can be used for effectively expelling vivotoxin and especially used for expelling toxins from livestock and preventing virus infection. The toxin-expelling powder is prepared from the following raw materials in parts by weight: cottonrose hibiscus leaves, viola inconspicua, vanilla, liquorice and the like which are dried and smashed; or the cottonrose hibiscus leaves, the vanilla, the liquorice, a small amount of the viola inconspicua and the like which are dried and smashed. The toxin-expelling powder cannot generate toxic and side effect. When the livestock is fed by a feed in which the toxin-expelling powder is added, the disease and the death of the livestock are avoided. Thus, the working time of a veterinarian is reduced. The toxin-expelling powder can be used as a necessary preventive medicine for farmers in livestock raising such as pig raising and the like. In addition, the toxin-expelling powder is processed simply and cannot generate compounds. The raw material sources are wide; and raw materials can be planted both in southern and northern in China.
FIELD: veterinary medicine, agriculture. SUBSTANCE: for prophylaxis and treatment of dyspepsia a mixture of milk and preparation antidiarrhin is fed to calf. The preparation consists of 30 g of citric acid, 5 g of sodium chloride and water - up to 100 ml. The dose is 6-20 ml per one liter of milk. Then 100-200 ml of rumen content from adult animal are given also. EFFECT: simple and highly effective method. 7 cl, 2 ex