anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Dietary supplement. The formula is based in free amino-acid to treat children with cow's milk allergy. The children should have a minimum consumption of 400 mL, daily.
Potassium channel openers (A1) in combination with sodium channel inhibiting or influencing substances (B1) or their salts are used in treatment of pains accompanied by increase in muscle tone. ACTIVITY : Analgesic. Muscle relaxing effect on reserpine-induced muscular rigidity in rats was measured using flupirtine and tolperisone. Male rats weighing 200-250 g were kept under standard conditions without any restriction in food or water and rigidity of the skeletal muscle measured by consecutively measuring the resistance of the flexor and extensor muscle, which acts in opposition when stretching and bending the foot in the joint. Freshly prepared flupirtine (5 mg/kg) and tolperisone (12.5 mg/kg) were administered intraperitoneally, 16 hours after the reserpine injection (2 mg/kg). The muscle relaxing effect measured was 71.1%. The result showed that the muscle relaxing effect of flupirtine was amplified superadditively by tolperisone and vice versa. MECHANISM OF ACTION : Synergist.
Tuberculosis (TB) remains the most important infectious disease in the world. In Taiwan, the incidence of TB increased in recent years. The failure of control implies the necessity to reevaluate the epidemiology of Mycobacterium tuberculosis. It is widely thought that most cases of TB are caused by reactivation of a latent infection. Treatment programs have therefore focused on cure rates rather than tracking of additional cases. But recent studies showed that exogenous reinfection plays an important role in the development of TB. In addition, it seems that the higher the local incidence, the more important exogenous reinfection is. The question of exogenous reinfection versus endogenous reactivation has an impact on the distribution of resources for the prevention and treatment of TB. Based on these evidences, we hypothesize that exogenous reinfection is very important in the Taiwan endemic. Therefore, we design a series of studies to evaluate the individual contribution of exogenous reinfection and endogenous reactivation in the Taiwan endemic, and to realize the impact of exogenous reinfection. First, we will identify the patients with TB relapse after complete treatment. The M. tuberculosis isolates responsible for their initial and recurrent episodes will then be genotyped to clarify the percentage of exogenous reinfection and endogenous reinfection.
### Teratogenic Effects.

Pregnancy Category B: Reproduction studies have been performed in rats and rabbits with mupirocin administered subcutaneously at doses up to 22 and 43 times, respectively, the human topical dose (approximately 60 mg mupirocin per day) on a mg/m2 basis and revealed no evidence of harm to the fetus due to mupirocin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Centany (mupirocin ointment),2% is administered to a nursing woman.

Pediatric Use: The safety and effectiveness of Centany (mupirocin ointment),2% have been established in the age range of 2 months to 16 years. Use of Centany (mupirocin ointment),2% in these age groups is supported by evidence from adequate and well-controlled studies of Centany (mupirocin ointment),2% in impetigo in pediatric patients studied as a part of the pivotal clinical trials. (See CLINICAL STUDIES.)
Retrospective registry of 500 patients who have received the Synergy stent. Data will be mined from the DES registry database for the identified Synergy patients at the following time points, in-hospital and then at 1 year, 2 years, 3 years, and 4 years after percutaneous coronary intervention (PCI).
Process for obtaining a prophylactic or therapeutic vaccine against a specific disease is characterized by taking blood direct from a person or animal having the disease, diluting it with an isotonic liquid to a concentration of from 1 in 30 to 1 in 1000, and destroying or attenuating the virulence of the pathogenic agents by physical, chemical or biological means, there being no cultivation of the active principle of the vaccine in an artifical medium.  The dilution may be carried out with physiological saline.  In preparing a prophylactic vaccine against "polio" blood is taken from a monkey convalescing from the disease, diuted with physiological saline and the coloured constituents removed. The so-formed serum is irradiated with ultra-violet light and placed in a sterile bottle.  A second monkey is inoculated with the same virus as the first, and venous blood removed during the fever period.  This is diluted with saline. 25 per cent of the total volume is further diluted with physiological saline and exposed to ultra-violet light, and bottled.  A second 25 per cent is mixed with the treated serum from the first animal and the remainder is diluted with physiological saline.  The three preparations are injected according to a special schedule described in the Specification.  For oral administration the preparations may be enclosed in suitable enteric capsules.  The preparation of a therapeutic vaccine against undulant fever is described.
United States: Olmesartan medoxomil 20 mg plus hydrochlorothiazide 12.5 mg fixed dose combination tablets, titrated up to olmesartan medoxomil 40 mg plus hydrochlorothiazide 25 mg orally, once daily for up to 52 weeks. Europe: Olmesartan medoxomil 20 mg plus hydrochlorothiazide 12.5 mg fixed dose combination tablets, titrated up to olmesartan medoxomil 20 mg plus hydrochlorothiazide 25 mg orally, once daily for up to 52 weeks.
A total of 20 (10 M, 10 F) stunted rural Malawian children aged 36-60 months will be studied to determine if there is an effect of feeding RS on zinc homeostasis and environmental enteropathy. These children are at high risk for zinc deficiency and environmental enteropathy by their demographic characteristics. Children will first have a quantitative assessment of zinc homeostasis where each child is given 2 zinc stable isotopes, one by mouth and another intravenously, which is followed by a stool and urine collection of 4 days. Zinc isotopes are quantified in the feces and urine, and these values are used to calculate the primary outcome, net zinc balance. This is followed by an assessment of environmental enteropathy quantitatively measured using the non-invasive site specific sugar absorption test, where each child drinks 100 mL of a sugar solution and a urine collection follows. The quantities of non-metabolizable sugars are measured, and the ratio of two of the sugars, lactulose and mannitol, is a measure of environmental enteropathy. Then the children will receive a dietary supplement, corn starch that has been modified to reduce its dietary absorption, for 5 weeks, which they will add to their phala. The RS is a standard food product that has been used safely in many millions of people for several decades. After taking this RS for 4 weeks both the zinc stable isotope test and the dual sugar absorption test will be repeated on the children to see if they have improved. These results will offer preliminary data as to whether RS might be used effectively on a large scale in the community to alleviate zinc deficiency and/or environmental enteropathy.
This study is a prospective cohort with a randomized single-blinded intervention with convenience sampling design. Our pediatric emergency medicine department (PED) treats nearly 2,500 patients between 1 and 3 years of age annually in 2008-10 and is a regional referral center for specialty care for our state. All data is collected in the PED between May 2008 and July 2010.

One PED examination room is designated as the study room. The music was stored on an ipod played in a portable speaker. The music is from the Compact Disk(CD), "Baby Go to Sleep." This is a commercially available CD.23 The "Baby Go to Sleep" Compact Disk played a combination of the sound of an actual human heartbeat and children's songs. Tempo changes occurred between each song. During the study, the initial three nursery rhymes were played.

The principal investigator's research associates recruit all patients up to 3 years of age presenting to the PED during the hours they were available. Once situated in the room, children both in the control and experimental group received the usual medical care including the evaluation by attending physician to determine if head CT would be performed or not. After subjects were determined to need a head CT by the attending physicians, they were randomly assigned to either the Control(Con) or experimental(Exp) group. Children in the Con group received the usual medical care while children in the Exp group received the usual medical care in combination with the intervention. The intervention was started by the patients nurse without the knowledge of the research associate. In the intervention group, music was played until the CT scan was completed. Research associates rated children's anxiety levels using a visual analogue scale(VAS) and Modified Ramsay Sedation Scale(MRSS) before children were transferred to radiology department for head CT then after children was laid down to go through head CT. Researchers associates were blinded to group by wearing headphones that were tested to ensure that they could not hear whether or not music was playing during the intervention phase.
OBJECTIVE: Reliable interpretation of imaging findings is essential for the diagnosis of axial spondyloarthritis (axSpA) and requires a high level of experience. We investigated experience-dependent differences in diagnostic accuracies using X-ray (XR), MRI and CT.
METHODS: This post hoc analysis included 163 subjects with low back pain. Eighty-nine patients had axSpA, and 74 patients had other conditions (mechanical, degenerative or non-specific low back pain). Final diagnoses were established by an experienced rheumatologist before the reading sessions. Nine blinded readers (divided into three groups with different levels of experience) scored the XR, CT and MRI of the sacroiliac joints for the presence versus absence of axSpA. Parameters for diagnostic performance were calculated using contingency tables. Differences in diagnostic performance between the reader groups were assessed using the McNemar test. Inter-rater reliability was assessed using Fleiss kappa.
RESULTS: Diagnostic performance was highest for the most experienced reader group, except for XR. In the inexperienced and semi-experienced group, diagnostic performance was highest for CT&MRI (78.5% and 85.3%, respectively). In the experienced group, MRI showed the highest performance (85.9%). The greatest difference in diagnostic performance was found for MRI between the inexperienced and experienced group (76.1% vs 85.9%, p=0.001). Inter-rater agreement was best for CT in the experienced group with κ=0.87.
CONCLUSION: Differences exist in the learnability of the imaging modalities for axSpA diagnosis. MRI requires more experience, while CT is more suitable for inexperienced radiologists. However, diagnosis relies on both clinical and imaging information.
The efficacy of vaccination, incomplete treatment and disease relapse are critical challenges that must be faced to prevent and control the spread of infectious diseases. Age heterogeneity is also a crucial factor for this study. In this paper, we investigate a new age-structured SVEIR epidemic model with the nonlinear incidence rate, waning immunity, incomplete treatment and relapse. Next, the asymptotic smoothness, the uniform persistence and the existence of interior global attractor of the solution semi-flow generated by the system are given. We define the basic reproduction number R 0  and prove the existence of the equilibria of the model. And we study the global asymptotic stability of the equilibria. Then the parameters of the model are estimated using tuberculosis data in China. The sensitivity analysis of R 0  is derived by the Partial Rank Correlation Coefficient method. These main theoretical results are applied to analyze and predict the trend of tuberculosis prevalence in China. Finally, the optimal control problem of the model is discussed. We choose to take strengthening treatment and controlling relapse as the control parameters. The necessary condition for optimal control is established.
This is a single-arm, 20 subject, pilot clinical trial utilizing 18F-fluciclovine PET/CT scan prior to treatment for brain metastatic lesion(s). Patients with recently diagnosed brain metastatic lesion(s) will be recruited based on MRI with or without histological confirmation, per standard of care. All patients will undergo an 18F-fluciclovine head PET/CT scan. The study will characterize uptake dynamic PET images over 60 minutes. Uptake within the lesions and the benign brain parenchyma will be plotted on a time activity curve for 60 mins. The investigators hypothesize that uptake will be above benign brain parenchyma. The 18F-fluciclovine PET/CT will serve as a baseline PET/CT scan.

Subjects will undergo a second 18F-fluciclovine PET/CT to evaluate 18F-fluciclovine uptake in treated lesions over 60 minutes. This will be offered concurrently with the post-procedure SOC MRI to evaluate post-treatment changes. Uptake within the lesions and the benign brain parenchyma will be plotted on a 60 min time activity curve. Results will be compared to the pre-treatment baseline images. Absolute SUV values of the lesions will be compared with contralateral normal brain, cerebellum, pituitary gland, and superior sagittal sinus. The investigators hypothesize that uptake of lesions with complete response will demonstrate significant reduction of uptake with persistent mild uptake above the pituitary gland. Focal uptake will be considered as residual viable disease. The truth will be correlated with histology confirmation, SOC images, or follow up.

A third 18F-fluciclovine PET/CT will be offered to evaluate post radiation changes necrosis from recurrence, for up to 10 patients in our cohort who are under clinical surveillance (up to three years surveillance) and developed MRI evidence of either true progression or radionecrosis with clinical uncertainty after stereotactic radiosurgery. The investigators hypothesize that the absolute uptake of lesions with radionecrosis will be significantly lower than that of true progression. The initial 18F-fluciclovine PET/CT will serve as a baseline PET/CT scan. This will be compared to post procedural histological confirmation.

If study results are promising, a larger prospective cohort study will be designed.
PURPOSE: To use a liquid composition as a surface coating layer of plastic and lotion for the hair by constituting particles which are the microdispersion in the liquid composition of a mixture composed of a specific amount of wax, a specific amount of a cationic emulsifier and in some cases a specific amount of oil and/or liposoluble active component. CONSTITUTION: A stable microdispersion of which the dispersion phase is composed of particles below 0.5 μ is obtained as the liquid composition existing in the form of the dispersion of wax in a fluid vehicle composed of a single phase. The particles are composed of the mixture composed of at least one kind of the wax, at least one kind of the cationic emulsifier and in some cases at least one kind of the oil and/or liposoluble active component. The mixture has a final melting point higher than 50 deg.C and lower than 100 deg.C. The composition contains 0.1 to 40 wt.% wax and 0.01 to 25 wt.% emulsifier. The composition is so formulated that the concentration of the oil is below 30 wt.% of the weight of the wax or the mixture of the wax if the oil exists in the composition.
A pharmaceutical composition containing chlorogenic acid and derivative thereof are provided to treat allergic conjunctivitis and infectious conjunctivitis using a pharmaceutically allowable carrier. A pharmaceutical composition comprises chlorogenic acid, derivative thereof and a pharmaceutically allowable carrier. The conjunctivitis indicates allergic conjunctivitis or infectious conjunctivitis. The infectious conjunctivitis is viral conjunctivitis, bacterial conjunctivitis, fungal conjunctivitis, chlamydial conjunctivitis, rickettsial conjunctivitis or parasitic conjunctivitis. The chlorogenic acid is represented by the formula 1. The chlorogenic acid normally exists in fruits of dicotyledones and the chemical name is 3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid.
Treatment with SPRYCEL is associated with severe (NCI CTCAE Grade 3 or 4) thrombocytopenia, neutropenia, and anemia, which occur earlier and more frequently in patients with advanced phase CML or Ph+ ALL than in patients with chronic phase CML [see Adverse Reactions (6.1)].

In patients with chronic phase CML, perform complete blood counts (CBCs) every 2 weeks for 12 weeks, then every 3 months thereafter, or as clinically indicated. In patients with advanced phase CML or Ph+ ALL, perform CBCs weekly for the first 2 months and then monthly thereafter, or as clinically indicated.

In pediatric patients with Ph+ ALL treated with SPRYCEL in combination with chemotherapy, perform CBCs prior to the start of each block of chemotherapy and as clinically indicated. During the consolidation blocks of chemotherapy, perform CBCs every 2 days until recovery.

Myelosuppression is generally reversible and usually managed by withholding SPRYCEL temporarily and/or dose reduction [see Dosage and Administration (2.5)].
PURPOSE: Community rehabilitation is crucial for the long-term treatment of people with chronic psychotic disorder. Ethnic minorities are less likely to seek care and have accessible treatment. This study examines whether the use of rehabilitation services and the relationship between rehabilitation and number of hospitalization days differ between Arabs and Jews.
METHODS: Data from the Israel National Psychiatric Case Register on 18,684 adults with schizophrenia/schizoaffective disorders hospitalized in 1963-2016 were merged with data from the national Mental Rehabilitation Register. Associations between the use of rehabilitation services and demographic and clinical characteristics were assessed through logistic regression modeling. Associations between ethnicity and duration of rehabilitation (housing or vocational) and annual hospitalization days during Period1: 2001-2009 and Period2: 2010-2016 were analyzed using ANOVA.
RESULTS: Among Jewish patients (N = 2556), 37% and 57% used rehabilitation services during Period1 and Period2, respectively, compared with 18% and 40% among Arab patients (N = 15,145) (p < 0.0001). The use of rehabilitation services was significantly higher among Jews (adjusted OR = 2.26, 95% CI 2.07-2.47). Average duration of housing and vocational rehabilitation services did not differ between Arab and Jewish patients. In both groups, duration of rehabilitation was inversely associated with annual hospitalization days.
CONCLUSIONS: The ethnic disparity in the use of rehabilitation services has narrowed over time, yet remains. Although fewer Arab patients use rehabilitation, Jewish and Arab benefit similarly from the services with regard to reduced hospitalization days. To further close the ethnic gap, greater efforts must be made to expand the availability of culturally appropriate rehabilitation services for the Arab minority.
Provided is a preparation method for chicken tail oil skin care emulsion. The chicken tail oil skin care emulsion comprises components, by weight, 1.5-10 parts of poultry uropygial gland oil and 90-98.5 parts of common skin care cosmetic. The chicken tail oil skin care cosmetic is paste or liquid, and the common skin care cosmetic is paste or liquid. The poultry uropygial gland oil is chicken uropygial gland oil. Secreta of a uropygial gland contain 7-dehydrocholesterol which has a function of nourishing feathers, ergosterol in the secreta can be changed into vitamin D which can be absorbed by skin under irradiation of ultraviolet rays, and thus poultry feathers are glossy, and the poultry uropygial gland oil has moisture retention and nourishing functions. The preparation method is as follows: firstly, chicken uropygial gland oil and common skin care cosmetic are weighed according to the weight ratio, and if the common skin care cosmetic is liquid, the weight of the common skin care components of the common skin care cosmetic is converted; secondly, the chicken uropygial gland oil is added in the common skin care cosmetic at a temperature of 45 DEG C, full mechanical stirring is carried out, after the chicken uropygial gland oil and the common skin care cosmetic are blended fully, and the mixture is cooled to the room temperature.
Coronary sinus reducer implantation is a percutaneous technique creating a narrowing in the coronary sinus through the implantation of an hourglass-shaped endoprosthesis. It is proposed to reduce symptoms in patients suffering from refractory angina pectoris. This innovative treatment is experiencing a major craze among interventional cardiologists. It is associated with very high procedural success rates. Complications are rare and include coronary sinus dissection or perforation and migration of the device. This review exposes the device implantation technique, the potential anatomical difficulties, the tips and tricks to overcome challenging situations. It also focuses on the prevention and management of potential complications.
Telocytes are closely associated with the regulation of tissue smooth muscle dynamics in digestive system disorders. They are widely distributed in the biliary system and exert their influence on biliary motility through mechanisms such as the regulation of CCK and their electrophysiological effects on smooth muscle cells. To investigate the relationship between telocytes and benign biliary diseases,such as gallbladder stone disease and biliary dilation syndrome, we conducted histopathological analysis on tissues affected by these conditions. Additionally, we performed immunohistochemistry and immunofluorescence double staining experiments for telocytes. The results indicate that the quantity of telocytes in the gallbladder and bile duct is significantly lower in pathological conditions compared to the control group. This reveals a close association between the decrease in telocyte quantity and impaired gallbladder motility and biliary fibrosis. Furthermore, further investigations have shown a correlation between telocytes in cholesterol gallstones and cholecystokinin-A receptor (CCK-AR), suggesting that elevated cholesterol levels may impair telocytes, leading to a reduction in the quantity of CCK-AR and ultimately resulting in impaired gallbladder motility.Therefore, we hypothesize that telocytes may play a crucial role in maintaining biliary homeostasis, and their deficiency may be associated with the development of benign biliary diseases, including gallstone disease and biliary dilation.
The Equal Attention Control consists of 8 sessions (7 group and one individual) that meet weekly for 60-90 minutes. The control sessions provide equal attention and psychotherapeutic experience of a support group where participants can address issues important in their lives.