anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses an antiseptic bactericidal condensed hand lotion. The antiseptic bactericidal condensed hand lotion comprises, by weight, 2-4% of a radix astragali extracting solution, 3-8% of polyoxyethylene lauryl ether, 3-5% of a phellodendron extracting solution, 2-5% of rose essential oil, 3-5% of thickening powder, 12-15% of liquid soap, 5-10% of tea tree oil, 2-4% of essence and the balance deionized water. The traditional Chinese medicine extracting solution are extracted respectively from 15-20 parts by weight of radix astragali and 25-35 parts by weight of phellodendron as raw materials by water as an extraction liquid and have d of 1.9-2.5g/ml. The antiseptic bactericidal condensed hand lotion has a high concentration and a large condensation degree, effectively saves a production cost and improves a product utilization rate. The used extract solutions of radix astragali, phellodendron and honeysuckle flower can effectively inhibit bacteria and kill bacteria. The Chinese herbal medicine components can effectively protect hand skin. Through use of the liquid soap, a dirt-removal capability is guaranteed. The antiseptic bactericidal condensed hand lotion has simple composition and strong practicality.
FIELD: medicine. SUBSTANCE: described are new aminosubstituted pyrazoles of general formula:   wherein R 1 -R 3 , A, Z and Y are as defined in claim 1. Said pyrazoles have antagonistic activity with respect to releasing factor of corticotropin. They are effective in treating wide range of diseases including stress induced disease. Also described are intermediate aminosubstituted pyrazines. EFFECT: improved properties of the title compounds. 13 cl, 36 ex, 4 tbl
Disclosed is an emotion recognition method based on multivariate multiscale fuzzy entropy analysis of electroencephalogram. Among several physiological signals, an electroencephalography (EEG) signal is an immediate and continuous signal of brain activity and is mainly used for emotional analysis because of directly reflecting a change of an emotional state of a person. To express the emotional state as entropy of EEG signals recorded from several EEG electrodes (quantifying complexity) and show features on multiple time scales, the emotional state is analyzed by using a method of combining multivariate fuzzy entropy (mvFE) and multivariate empirical mode decomposition (MEMD). Analysis of the emotional state is performed by using EEG data of DEAP which is a public database. The emotional state can be distinguished through binary classification of higher/lower arousal and positive/negative emotions (Valance) than a reference value. The emotion recognition method based on multivariate multiscale fuzzy entropy analysis of electroencephalogram comprises: a step of measuring, storing, and comparing a reference EEG signal with an experimental EEG signal; a step of distinguishing the emotional state; and a step of analyzing the emotional state.
In the era of artificial intelligence, privacy empowerment illusion has become a crucial means for digital enterprises and platforms to "manipulate" users and create an illusion of control. This topic has also become an urgent and pressing concern for current research. However, the existing studies are limited in terms of their perspectives and methodologies, making it challenging to fully explain why users express concerns about privacy empowerment illusion but repeatedly disclose their personal information. This study combines the associative-propositional evaluation model (APE) and cognitive load theory, using event-related potential (ERP) technology to investigate the underlying mechanisms of how the comprehensibility and interpretability of privacy empowerment illusion cues affect users' immediate attitudes and privacy disclosure behaviours; these mechanisms are mediated by psychological processing and cognitive load differences. Behavioural research results indicate that in the context of privacy empowerment illusion cues with low comprehensibility, users are more inclined to disclose their private information when faced with high interpretability than they are when faced with low interpretability. EEG results show that in the context of privacy empowerment illusion cues with low comprehensibility, high interpretability induces greater P2 amplitudes than does low interpretability; low interpretability induces greater N2 amplitudes than does high interpretability. This study extends the scopes of the APE model and cognitive load theory in the field of privacy research, providing new insights into privacy attitudes. Doing so offers a valuable framework through which digital enterprises can gain a deeper understanding of users' genuine privacy attitudes and immediate reactions under privacy empowerment illusion situations. This understanding can help increase user privacy protection and improve their overall online experience, making it highly relevant and beneficial.
This research project is a study designed to address both motor and cognitive changes after stroke, two common stroke disabilities. For example: two third of patients reported loss of upper limb function as a major problem after stroke and spatial neglect occurs in more than 350,000 US right hemisphere stroke survivors annually. These two impairments if not treated, lead to immediate impairment in basic life activities, long term functional disability, increased risk for falls and increased healthcare costs. The literature displays many strong research studies that trialed the use of multiple treatment approaches to remediate spatial neglect, including prism adaptation treatment (PAT), resulting in positive results. Similar findings result for treatment studies that attempt to remediate the upper extremity (UE). However, in all group of patients that were tested in these studies (both for spatial neglect and UE dysfunction) only had one stroke and past medical histories that were unremarkable. Rehabilitation professionals help clients that have had all types of strokes achieve improved quality of life by helping to increase independence by remediating impairment. In addition, these professionals need to know more about the effects of PAT in stroke survivors with multiple lesions because these are patients commonly being treated in the clinical setting. Also, it has not been investigated whether using PAT, a very promising and easy to administer treatment, to remediate spatial neglect will also increase spontaneous UE movement of the limb affected by the stroke because of an influence on motor-intentional aiming errors. Thus, in this pilot research proposal, the researcher intends to first investigate the feasibility of this two week treatment on stroke survivors that have had multiple lesions and second verify if PAT will improve spatial neglect and jointly increase spontaneous movement of the UE.
INTRODUCTION: Laparoscopic IPOM is technically challenging, especially regarding fascial closure. Hybrid repair has been proposed as a simpler approach. We aimed to compare hybrid and laparoscopic intraperitoneal onlay mesh repair (IPOM) in patients undergoing ventral hernia repair (VHR).
METHODS: We performed a systematic review of Cochrane, Scopus, and MEDLINE databases to identify studies comparing hybrid versus laparoscopic IPOM VHR reporting the outcomes of recurrence, mortality, seroma, postoperative complications, reoperation, surgical site infection, and operative time. Statistical analysis was performed using RStudio 4.1.2 using a random-effects model.
RESULTS: We screened 2,896 articles and fully reviewed 22 of them. A total of five studies, encompassing 664 patients were included. Among them, 337 (50.8%) underwent laparoscopic IPOM. All patients had incisional hernias, with a mean diameter varying from 3 to 12.7 cm, 60% were women, with a mean BMI varying from 29.5 to 38. The hybrid approach had a lower rate of seroma when compared to the laparoscopic (OR 0.22; 95% CI 0.05 to 0.92; p = 0.038; I²=78%). We found no difference in recurrence, mortality, postoperative complications, reoperation, surgical site infection, and operative time between groups.
CONCLUSION: Hybrid IPOM is a safe and effective method for incisional hernia repair. Moreover, it facilitates fascial defect closure and decreases postoperative seromas.
The present invention relates to the preparation and use of compositions for the treatment of skin disorders itchy and/or infected skin such as impetigo, acne (on face, forehead scalp and on the back of the body) and fungal infection of skin and nails. Whether the infection may be acute or chronic or sub-acute or acute on chronic. As well as for the promotion of non carrier state of the human beings and animals from some pathogenic bacteria such as staphylococci. The compositions are based on extracts from the plants Cassia tora, Centratherum anthelminticum and/or Melia azadirachta. A variety of other herbal extracts may be included and the composition may take the form of a freeze dried or a spray dried powder or presence of this in a cream or ointment based on Ghee, or in a cream or ointment form developed with any other vehicle, or they may be in a powdered form without spray drying. That spray dried or freeze dried powder may be suspended in a suitable mouth wash or nasal drops. The herbs may be in a powdered form of suitable for preparing decoctions in hot water. Laboratory results are of Specimen Example 2. Specimen Example 1 I have found working on the patients clinically as broad spectrum covering pustules as well as fungal infections.
In two controlled clinical trials, 160 patients with advanced prostate cancer were randomized to receive either one 3.6 mg ZOLADEX implant every four weeks or a single 10.8 mg ZOLADEX implant every 12 weeks. Mean serum testosterone suppression was similar between the two arms. PSA falls at three months were 94% in patients who received the 10.8 mg implant and 92.5% in patients that received three 3.6 mg implants. 

Periodic monitoring of serum testosterone levels should be considered if the anticipated clinical or biochemical response to treatment has not been achieved. A clinical outcome similar to that produced with the use of the 3.6 mg implant administered every 28 days is predicted with ZOLADEX 10.8 mg implant administered every 12 weeks (84 days). Total testosterone was measured by the DPC Coat-A-Count radioimmunoassay method which, as defined by the manufacturers, is highly specific and accurate. Acceptable variability of approximately 20% at low testosterone levels has been demonstrated in the clinical studies performed with the ZOLADEX 10.8 mg depot.
A non-invasive imaging device obtains a four dimensional (4D) image data set of a living subject representing three dimensions and time in relation to the subject's cardiac cycle. In order to determine various vascular parameters, it is useful to segment the image data set into internal structures defined as having the same tissue types contiguous locations. To accomplish this, a gradient calculation unit constructs a gradient data set from the image data set indicating the magnitude of spatial changes in the image data set. A plurality of locations are selected by an operator with a pointing device during `training` along with corresponding data values in the image and gradient data sets. These data values are plotted by a scatter generator against each other to construct a scatter plot then processed to determine a bivariate statistical probability distribution. The remaining data values are then assigned a tissue type based upon their plot on the bivariate statistical probability distribution. Contiguous locations having the same tissue type assignment are identified as a solid structure by a connectivity calculator. These solid structures may be the internal volume of cardiac chambers. Since these volumes may be accurately measured over the cardiac cycle, a functionality calculator determines vascular functionality, such as ejection fraction, and cardiac output and displays the results on a monitor to the operator.
<P>PROBLEM TO BE SOLVED: To provide an apparatus and a method for introducing a hair growth agent which introduce a hair growth agent effectively into the scalp and make the hair growth agent sufficiently penetrate the scalp and the inside of the pores irrespective of the kind of the hair growth agent.  <P>SOLUTION: The apparatus 1 for introducing a hair growth agent includes a pulse applying section that generates electric pulses and electrodes 41 connected electrically with the pulse applying section for applying the electric pulses generated by the pulse applying section to the scalp of a user. Because the apparatus introduces a hair growth agent via the scalp using an electroporation method, the hair growth agent sufficiently penetrates the scalp and the inside of the pores irrespective of the kind of the hair growth agent. The electrodes 41 of the apparatus 1 may be formed in the shape of bars and the plurality of electrodes may be arranged on a distal part 40 of a brush-like electrode unit 4. With such a configuration, the electrodes 41 are abutted on the scalp in a similar way to comb the hair to introduce the hair growth agent. The apparatus has excellent maneuverability and facilitates introduction of the hair growth agent via the scalp.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Single-group crossover trial with 100 total participants. Participants will use Pamprin Botanicals during their first period and both Pamprin Botanicals and over-the-counter Pamprin Menstrual Relief during their second period.
The present invention relates to a recipe of Chinese traditional medicine for promoting blood circulation and reducing blood fat, and a preparation thereof. The recipe of traditional Chinese medicine for promoting blood circulation and reducing blood fat disclosed by the present invention is composed of 0.5 to 5% saffron, 49 to 70% of safflower and 29 to 50% of gold theragran by weight. The medicine can be made into tea bags, health-care beverages and various oral preparations, such as granules, capsules, tablets, etc. by a conventional method. The recipe of the present invention can be used for effectively controlling coronary heart disease and hyperlipidemia, and has significant curative effects on blood stasis dysmenorrhoea of gynecology. Various preparations made by the recipe of the present invention has specific efficiency; the present invention is convenient to take, and has good clinic popularization and application values.
Administer 100 mg cilostazol, twice daily for 14 days. In addition, implement the standard treatment regimen of 60 mg nimodipine every 4 hours for 21 days, and the standard aneurysmal subarachnoid treatment pathway.
OBJECTIVE: To develop Plectranthus amboinicus extract loaded Polyurethane foam dressing for burn wound healing.
SIGNIFICANCE: Plectranthus amboinicus is traditionally used as an anti-inflammatory and wound-healing agent. Its incorporation in a PU foam dressing will offer the dual benefits of foam dressing as well as the healing potential of P. amboinicus.
METHODS: PU foam dressings were prepared and loaded with P. ambionicus leaf extract (PAE). The dressings were prepared with varying concentrations (0.5-2%) of extract along with Toluene diisocyanate, polypropylene glycol (PPG), and liquid paraffin. The dressings were characterized by Scanning Electron Microscopy and evaluated for Moisture Vapor Transmission Rate, absorption rate, porosity, and mechanical strength followed by in vivo burn wound-healing studies in comparison to a marketed dressing.
RESULTS: The MVTR was found to be optimum in formulations FD2-FD4 with values ranging from 2068.06 ± 0.99 to 2095.00 ± 0.25 g/m2/day. Absorption rate was found to be between 1.27 ± 0.01, 1.31 ± 0.00, and 1.30 ± 0.02 g/cm2 for formulations FD2-FD4. Formulations FD1, FD2, FD3, FD4 showed better porosity when compared to other formulations. Formulation FD4 was further characterized by micro-CT and a porosity of 46.32% was obtained. Tensile strength measurement indicated that the selected formulations were flexible enough to withstand regular handling during dressing changes. Acute dermal irritation performed on rabbits showed no irritation, erythema, eschar, and edema. In vivo wound-healing studies performed on albino wistar rats showed that the FD4 formulation has better wound healing property.
CONCLUSION: Plectranthus ambionicus-loaded PU foam dressing demonstrated promising burn wound-healing potential.
Patient must be between 18 and 80 years old and have problems with the bones in there lower back (lumbar disease) for which Cautious management over at least 3 months has not brought relief from back and/or leg pain. Patients will be scheduled to undergo surgery to treat there lumbar disease. The surgery will be followed by placement of screws in the back of the bones of there lower back. This includes placing solid metal rods that are connected and secured to adjacent vertebrae (bones of the back) using screws. The screws are used to hold the spine together. Everyone who takes part in this study will be assigned to one of the following 3 study groups: 1) One-sided screw placement into the bones above and below the area where the nerve is being surgically relieved of its pinching; 2) Same as group 1 but with an additional stand alone screw which crosses the spinal joint placed into the joint on the other side; 3) Screw placement on both sides into the bones above and below the area where the nerve is being surgically relieved of its pinching.
FIELD: medicine. SUBSTANCE: every of individual components of a pattern is a mini-tablet of less 5 mm size. All mini-tablets have practically the same size. Mini-tablet consists of a nucleus covered with two membranes. Nucleus contains an active ingredient such as calcitonin or ferritin. One of the membranes is designed from polymer soluble at pH above 5.0. The second membrane is made of practically insoluble polymer, which is permeable for gastrointestinal liquids. Multi-component dosed pattern at pH under the value of 4.5 reveals not higher than 10% calcitonin or ferritin. The rest part of an active ingredient is revealed at pH equal or above 5 during 0.5-8 hours. EFFECT: higher efficiency to provide controlled isolation of active intestinal ingredient. 8 cl
This invention relates to the therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells a chimeric gene containing an apoptosis-inducing gene (AIG) driven by a promoter of an inducible gene activated in inflammation and a promoter enhancer such that the inflammatory cells are targeted. In one embodiment, the chimeric gene comprises at least one TNF alpha promoter enhancer attached to a functional copy of a minimal TNF alpha promoter and further attached to at least one copy of an apoptosis-inducing gene, wherein expression of the gene is driven by the TNF alpha promoter. Attachment can be direct, distal, proximal or combinations thereof. Example apoptosis-inducing genes include caspase 3, caspase 4, caspase 5, Granzyme B. Advantageously, the TNFp-AIG chimeric gene is expressed in only those cells producing the inflammatory cytokine, TNF alpha . In addition, the TNFp-AIG chimeric gene also sequesters inducible TNFp transcription factors, thereby reducing endogenous production of TNF alpha . The invention also relates to methods of making and using self-regulated apoptosis chimeric genes and pharmaceutical compositions containing them for treating inflammatory diseases.
PURPOSE: The purpose of this study was to assess the risk factors that predispose patients with keratoconus to develop acute corneal hydrops (ACH), including both clinical and tomographic risk factors. We additionally describe tomographic changes of the cornea over time after ACH.
METHODS: We retrospectively reviewed patients with keratoconus who were followed at our institution from January 2015 to May 2023. Control eyes, defined as eyes with advanced keratoconus (stage IV Amsler-Krumeich classification on initial examination) were compared with eyes that developed ACH. Demographic, clinical, and tomographic factors were investigated. Visual acuity, keratometry, and corneal thickness were assessed at each follow-up visit to monitor progression over time.
RESULTS: Twenty-three eyes of 19 patients developed ACH over the follow-up period. The incidence of known clinical associations including seasonal allergies, eye rubbing, snoring, asthma, and eczema was similar between the hydrops and control groups. There was a higher incidence of Down syndrome in the hydrops group ( P = 0.04). Eyes that developed hydrops had similar best corrected visual acuity on initial examination, but had steeper keratometry ( P = 0.003) and thinner corneas ( P < 0.001) than controls at baseline. After hydrops, progressive corneal flattening and reduced maximum keratometry occurred over time. However, final best corrected visual acuity was worse compared with initial examination before hydrops ( P = 0.03), as well as compared with control eyes ( P < 0.001).
CONCLUSIONS: Risk factors of developing ACH include steep keratometry and thin corneas as well as Down syndrome. Although corneal flattening will occur after resolution of acute corneal edema, visual acuity worsened after ACH.
PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.
Subjects assigned to this arm will receive 5 intravenous infusions of HB-adMSCs at 50 million cells/dose. Infusions will occur at weeks 0, 2, 6, 10, and 14.
The invention discloses a traditional Chinese medicine for treating painful heel caused by damp-heat retardation. The traditional Chinese medicine is characterized by being prepared from the following medicinal materials in parts by weight: 15 parts of dioscorea althaeoides R. knuth., 10 parts of punctatelip woodbetony flowers, 10 parts of melodinus hemsleyanus diels, 12 parts of fraxinus malacophylla roots, 25 parts of acanthopanax ricinifliux seem roots, 15 parts of roots of Low greenbrier, 12 parts of glabriuscula a. juss, 25 parts of diploclisia glaucescens, 10 parts of abliflora, 20 parts of contorted tanglehead herb, 15 parts of roots of wilford Swallowwort, 15 parts of fewleaf schnabelia herb, 12 parts of viscum multinerve, 15 parts of sabia discolor dunn, 12 parts of sinomenium acutum, 8 parts of rhizoma dioscoreae nipponicae, 10 parts of roots of rustyhair raspberries, 10 parts of holly leaves, 20 parts of prickly pear fruits and 5 parts of liquorice. The medicine disclosed by the invention can be used for effectively treating painful heel caused by damp-heat retardation. Over the years, the use of the medicine on many patients shows that the effective rate reaches 100% and the cure rate reaches 96%. The curative effect is good and painful heel cured no long replase.