anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to isolated nucleic acid which encodes mammalian latheo protein (e.g., human). The present invention also relates to an isolated mammalian latheo protein (e.g., human). Also encompassed by the present invention are nucleic acid constructs, host cells, fusion proteins, antibodies and antisense nucleic acid. The present invention also relates to a method of producing a mammalian latheo protein. Also encompassed by the present invention are methods of identifying an agent that modulates (enhances, inhibits) interaction of latheo with a member of the origin recognition complex (e.g., ORC2, ORC4, ORC5, ORC6), a method of identifying an agent that modulates cell proliferation which results from latheo activity, a method of identifying sequence variants of latheo, a method of identifying an agent for use in the treatment of cancer, a method of identifying an agent to treat defects in synaptic function associated with a defective latheo and a method of identifying an agent to treat a cognitive dysfunction associated with latheo. Agents identified by the methods are also encompassed. The present invention also relates to methods of treating cancer, a defect in synaptic plasticity associated with a defective latheo and cognitive dysfunction associated with a defective latheo.
BACKGROUND: Despite stage IV categorization, survival outcomes for breast cancer patients who experience contralateral axillary lymph node metastasis (CAM) remain uncertain. This study aimed to investigate the clinical outcomes for patients with metachronous CAM to provide insights into its prognosis and treatment recommendations.
METHODS: This study retrospectively reviewed medical records of patients who underwent curative surgery for breast cancer and experienced CAM as the first site of distant metastasis (DM) during the follow-up period between January 2001 and April 2023. Survival outcomes of the CAM patients were compared with those of breast cancer patients with other DM via propensity score-matching (PSM).
RESULTS: The study identified 40 breast cancer patients with metachronous CAM. The estimated 5-year overall survival (OS) was 39.6%, and the progression-free survival was 39.4%. The patients with CAM exhibited marginally better OS than the patients with DM (p = 0.071), but survival similar to that of the patients with isolated supraclavicular node recurrence (SCN) (p = 0.509). Moreover, matching of CAM with DM using two PSM models showed a consistently insignificant survival difference (hazard ratio [HR], 1.47; p = 0.124 vs. HR, 1.19; p = 0.542). Ipsilateral breast tumor recurrences (IBTRs) were experienced by 12 patients before or concurrently with the CAM. These patients exhibited significantly better survival than the remaining patients (HR, 0.28; p = 0.024).
CONCLUSION: The breast cancer patients with CAM showed survival similar to that for the patients with DM, supporting the current stage IV classification of the CAM. However, CAM associated with IBTR exhibited superior survival outcomes, suggesting that this subset of CAM may benefit from treatments with curative intent.
Participants in this group will have the following performed: Institute of Mobility Activity and Participation (I-MAP's) clinical battery of tests and a simulated driving test, a Brief Driving Behavior Interview, Propensity for Angry Driving Scale, Clinical Driving Assessment, Community Integration Questionnaire, and a Satisfaction with Life Questionnaire. Driving safety professional, three x 1 hour sessions to discuss traffic safety, rules of the road, defensive driving, driving under influence, driver attitudes and safety. Additionally, the study will obtain real world driving data from the Department of Motor Vehicles (public records) which will include citations, violations, and recorded collisions/ crashes.
Overgrowth syndromes (OGS) comprise a heterogeneous group of disorders whose main characteristic is that the weight, height or the head circumference are above the 97th centile or 2-3 standard deviations above the mean for age, gender, and ethnic group. Several copy-number variants (CNVs) have been associated with the development of OGS, such as the 5q35 microdeletion or the duplication of the 15q26.1-qter, among many others. In this study, we have applied 850K SNP-arrays to 112 patients and relatives with OGS from the Spanish OverGrowth Registry Initiative. We have identified CNVs associated with the disorder in nine individuals (8%). Subsequently, whole genome sequencing (WGS) analysis was performed in these nine samples in order to better understand these genomic imbalances. All the CNVs were detected by both techniques, settling that WGS is a useful tool for CNV detection. We have found six patients with genomic abnormalities associated with previously well-established disorders and three patients with CNVs of unknown significance, which may be related to OGS, based on scientific literature. In this report, we describe these findings and comment on genes associated with OGS that are located within the CNV regions.
PURPOSE:A denitrifrice composition, containing an extract obtained by extracting a crude druge Japanese angelica root with a solvent, e.g. an ether, ester, ketone or alcohol, having improved hemostatic effect and good stability and feeling of use. CONSTITUTION:A Japanese angelica root is extracted with an ether, ester ketone, alcohol or hydrous substance, preferably ethyl ether or ethyl acetate having a low boiling point, as a solvent, and the resultant extract in an amount of 0.05-5wt%, based on the total weight, is incorporated to give a denitrifice composition. The extract of the Japanese angelica root has improved hemostatic effect and low degree of coloring on incorporating in the denitrifrice composition and good stability and feeling of use. Therefore, the extract is an excellent ingredient in the denitrifrice composition. The extraction of the Japanese angellica root is carried out by using the solvent in an amount of 3-20 times that of the Japanese angelica root, and preferably repeating the extracting operations at ordinary temperature -60 deg.C for 3- 48hr about three times. After removing the solvent, the resultant extract is used in the form of a concentrated extract.
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic reticulum protein regulatory programs and dysfunction of mitochondrial energy metabolism. Mitochondria and endoplasmic reticulum are seamlessly connected through the mitochondrial-associated endoplasmic reticulum membrane (MAM), which serves as a crucial site for the exchange of organelles and metabolites. However, there is a lack of reports regarding the communication of information and metabolites between mitochondria and related organelles, which is a crucial factor in triggering myocardial I/R damage. To address this research gap, this review described the role of crosstalk between mitochondria and the correlative organelles such as endoplasmic reticulum, lysosomal and nuclei involved in reperfusion injury of the heart. In summary, this review aims to provide a comprehensive understanding of the crosstalk between organelles in myocardial I/R injury, with the ultimate goal of facilitating the development of targeted therapies based on this knowledge.
The invention discloses a traditional Chinese medicinal preparation for treating orthopedic diseases, and a preparation method and an application thereof. The traditional Chinese medicinal preparation comprises, by weight, 16-24 parts of Herb of Dwarf Denseflower Elsholtzia, 20-28 parts of Sago Leaf, 1-5 parts of catechu, 11-20 parts of root of Syzygium buxifolium Hook. et Arn. and 8-16 parts of Dictyophora indusiata. The preparation method comprises the following steps: crushing the root of Syzygium buxifolium Hook. et Arn., carrying out CO2 supercritical extraction, adsorbing the obtained extract with macro-porous adsorption resin, pre-eluting the extract, and eluting the extract to obtain a Syzygium buxifolium Hook. et Arn. root medicine liquid; crushing catechu and Dictyophora indusiata, and carrying out high temperature treatment to obtain mixed powder; adding 50% ethanol to Dwarf Denseflower Elsholtzia and Sago Leaf to immerse Dwarf Denseflower Elsholtzia and Sago Leaf, heating the immersed materials to boil the immersed materials, filtering the obtained solution, and taking the obtained filtrate; and mixing the filtrate with the mixed powder and the Syzygium buxifolium Hook. et Arn. root medicine liquid, and carrying out heat treatment to obtain the traditional Chinese medicinal preparation. The traditional Chinese medicinal preparation has the efficacy of invigorating blood circulation and strengthening bones, warming channels and expelling cold, and relaxing veins and relieving pains, can be used to treat hyperosteogeny, femur head necrosis, traumatic injury and various orthopedic diseases and has the characteristics of fast effect, high cure rate, no recurrence after cure, no toxic or side effects, low production cost, and convenience for industrial production.
Patients receive bevacizumab as in arm I. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.
The control group received routine indwelling catheterization, the catheter was continuously opened, and the indwelling catheter was replaced every 7 days. When the bladder function returned to normal, the catheter was removed.
FIELD: medicine, narcology. SUBSTANCE: method involves administration of potentiated ethanol obtained by multiple successive dilution and shaking by homeopathic procedure. The parent substance is ethyl alcohol at dilution 100-10000. Method is combined with administration of potentiated morphine obtained by multiple dilution and shaking by homeopathic procedure from opium alkaloid morphine or opium alkaloids mixture containing 65-95 wt.-% morphine, or from morphine hydrochloride at dilution 200-1000. EFFECT: enhanced effectiveness of treatment. 4 cl
The present invention relates to a skin care mask, which comprises a breathing zone and a veneer zone. The breathing zone is located in a protrusion zone at the center of a skin mask, and is made of an air-permeable material. A space is formed between the breathing zone and a user face, and a user nostril is located in the space. The veneer zone is provided on left and right sides of the breathing zone to be applied to a user skin. The veneer zone includes: a sealing layer provided on one side of the veneer zone separated from the user skin; a skin care layer provided at one surface of the user skin opposite to the sealing layer, and including a skin care unit; and an air-permeable layer disposed in the veneer zone, and disposed on one side of the skin care layer close to the user skin. The skin care unit can be in contact with the user skin through the air-permeable layer, generates gas by occurring a reaction with moisture generated from the user skin, and allows the gas to be in contact with the user skin.
The invention discloses an extract of Amaranth, having enriched nitrate content, L-arginine, Flavonoids, saponins, alkaloids, carbohydrates, proteins, potassium, and with negligible amount of oxalic acid or oxalate content. The extract of Amaranth can be prepared from fresh or dried leaves and stem of Amaranth. It can be administered into different dosage viz. fast melt tablet, lozenge, candy, chewing gum, beverage, tablet, capsule, pill, and powder to patients. The said enriched extract of Amaranth has the capability to enhance nitric oxide concentration, nitrate level concentration, and nitrite level in blood as well as in saliva. Hence by administering it can lower blood pressure, increase physical endurance, increase swimming endurance, increase running endurance, and improve sexual performance among human beings.
BACKGROUND: Giant cell reparative granulomas are nonneoplastic, benign lesions that can expand and dissolve bone. Fibrous dysplasia is a benign condition in which normal bone tissue is replaced by abnormally proliferating immature reticular bone and fibrous tissue. The combination of giant cell reparative granuloma and fibrous dysplasia is extremely rare and can pose diagnostic and therapeutic challenges because of the complexity of clinical presentation.
CASE PRESENTATION: We here present a patient who had a combination of fibrous dysplasia of bone and a giant cell reparative granuloma. An elderly male was admitted to the hospital with a blood-streaked nasal discharge, blurry vision in his right eye, and an enlarged mass under the chin. A CT scan revealed that the lesion had infiltrated the head and face extensively, including the right maxillary sinus, sieve sinus, and the right nasal cavity, contraindicating surgery. The patient received a total dose of 30 Gy of 6 MV x-ray radiotherapy delivered through helical tomotherapy over 15 sessions, with a single dose of 2 Gy being administered five times a week. Concurrently, The dose is 4 mg of zoledronic acid administered intravenously once every 21 days. After treatment, the patient's nasal congestion was significantly relieved, the vision of the right eye improved, and the mandibular lesion was significantly reduced.
CONCLUSIONS: Treatment with radiotherapy combined with zoledronic acid for our patient's inoperable osteolytic giant cell reparative granuloma adjacent to vital nerves and blood vessels was extremely effective and safe. This case report provides a reference for the management of this rare combination.
Stroke survivors show a deterioration in bilateral coordination during gait that impacts functional mobility and quality of life. Such deterioration includes spatial (e.g. step length) and temporal (e.g. step time) inter-limb asymmetries during walking (gait asymmetry). While restoration of gait symmetry through adaptive exercise as in split-belt training is an answer, it is compounded by deficits of perception that is common in stroke survivors. One solution to this problem is the use of augmented visual feedback such as virtual reality (VR). Such augmented visual inputs during training can help remove sensory conflicts that commonly exist during gait rehabilitation (e.g. static visual input versus motion perception through proprioceptive input during treadmill walking). The PI's ongoing research investigating the effects of VR on gait adaptation in stroke survivors indicates that the impact of VR is dependent on the subject's baseline gait asymmetry such that the effect of VR is potentially higher in those who have large baseline asymmetries. Therefore, in the current proposal, to determine if this hypothesis is correct, chronic stroke survivors who are above and below a specific asymmetry threshold will be recruited and assessed for the effect of VR on a split-belt treadmill paradigm. In the second aim, the effect of VR on the transfer of split-belt adaptation to a preferred walking trial will be assessed. Since stroke survivors also suffer from major perceptual deficits related to symmetry, in the third aim, the effect of VR on gait adaptation on four groups of stroke survivors will be analyzed those with deficits only in perceiving visual asymmetry, only gait asymmetry, both deficits or neither.
INTRODUCTION: The prevalence of type 2 diabetes (T2D) has increased dramatically in recent decades, and there are increasing indications that dementia is related to T2D. Previous attempts to analyze such relationships principally relied on traditional multiple linear regression (MLR). However, recently developed machine learning methods (Mach-L) outperform MLR in capturing non-linear relationships. The present study applied four different Mach-L methods to analyze the relationships between risk factors and cognitive function in older T2D patients, seeking to compare the accuracy between MLR and Mach-L in predicting cognitive function and to rank the importance of risks factors for impaired cognitive function in T2D.
METHODS: We recruited older T2D between 60-95 years old without other major comorbidities. Demographic factors and biochemistry data were used as independent variables and cognitive function assessment (CFA) was conducted using the Montreal Cognitive Assessment as an independent variable. In addition to traditional MLR, we applied random forest (RF), stochastic gradient boosting (SGB), Naïve Byer's classifier (NB) and eXtreme gradient boosting (XGBoost).
RESULTS: Totally, the test cohort consisted of 197 T2D (98 men and 99 women). Results showed that all ML methods outperformed MLR, with symmetric mean absolute percentage errors for MLR, RF, SGB, NB and XGBoost respectively of 0.61, 0.599, 0.606, 0.599 and 0.2139. Education level, age, frailty score, fasting plasma glucose and body mass index were identified as key factors in descending order of importance.
CONCLUSION: In conclusion, our study demonstrated that RF, SGB, NB and XGBoost are more accurate than MLR for predicting CFA score, and identify education level, age, frailty score, fasting plasma glucose, body fat and body mass index as important risk factors in an older Chinese T2D cohort.
Methods and systems determine a health condition based on health data of a user of the respiratory system or an operating condition of the respiratory system. Health data or operational data is collected by a processing device local to the user. Methods and systems include analyzing the collected data to initially determine a potential health condition associated with a user or a potential operational fault condition of the respiratory system. In response to determining the potential condition, a command is sent for receipt by the remote server. The command will provide a health assessment module including instructions for analyzing the health data, or an operational fault assessment module including instructions for analyzing the operational data, to further assess the initially determined potential condition. A health assessment module or an operational failure assessment module is received on the processing device, and the health assessment module or the operational failure assessment module is updated to store the assessment module as executable instructions for analyzing the health data or the operational data to verify the initial determination.
OCALIVA is a farnesoid X receptor (FXR) agonist. Chemically, obeticholic acid is 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid. It is a white to off-white powder. It is soluble in methanol, acetone and ethyl acetate. Its solubility in water is pH dependent. It is slightly soluble at low pH and very soluble at high pH. Its chemical formula is C26H44O4, the molecular weight is 420.63 g/mol, and the chemical structure is:

OCALIVA tablets are supplied in 5 mg and 10 mg strengths for oral administration. Each tablet contains obeticholic acid as the active ingredient and the following inactive ingredients: microcrystalline cellulose, sodium starch glycolate, and magnesium stearate. The film coating is Opadry II (Yellow) containing polyvinyl alcohol-part hydrolyzed, titanium dioxide, macrogol (polyethylene glycol 3350), talc, and iron oxide yellow.
Skeletal muscles host \~40% of all protein in the body. Muscles are not only crucial for locomotion but also represent the body's largest metabolically active tissue, glucose disposal site and fuel reservoir for other organs in pathological conditions (i.e., supply of amino acids to the liver for gluconeogenesis). Muscle atrophy is characterized by a reduction in cross sectional area (CSA) and length and occurs in many common illnesses (e.g. cancers (1), renal/heart failure, sepsis, genetic diseases, neurodegenerative disorders etc). It is also prevalent in situations of reduced neural input such as leg casting after fractures (2), bed-rest, spinal cord injury (3), space flight and chronic physical inactivity. Atrophy results in a loss of muscle power and strength (which is related to increased morbidity and mortality (4)) and reduced capacities for whole-body glucose storage and metabolism which causes insulin resistance. Strategies to oppose atrophy are limited but include mechanical loading (5) and the synergistic anabolic effects of nutrients. Although muscle atrophy is of great clinical importance, relatively little mechanistic research has been done in humans. Thus, the aim of this study is to assess the link between the variation in muscle physiological responses to disuse atrophy with variation in protein turnover and molecular-networks. This will not only provide new hypotheses for physiological regulation of human muscle and generate 'intervention targets' derived from clinically relevant human studies, it will also improve understanding of whether the response to disuse is altered with age and determine if mechanistic differences in atrophy resistant and atrophy sensitive muscles might explain inter-muscular variation in susceptibility to atrophy.

This study aims to define the molecular and metabolic mechanisms causing disuse atrophy in both young and older individuals and explore how and why some muscles are protected against it. The study will also assess temporal aspects of disuse atrophy (in younger individuals only) to explore the mechanistic basis for the more rapid atrophy observed in the early days of disuse.
Fibroblast growth factor receptor (FGFR) alterations are present as oncogenic drivers and bypass mechanisms in many forms of cancer. These alterations can include fusions, amplifications, rearrangements, and mutations. Acquired drug resistance to current FGFR inhibitors often results in disease progression and unfavorable outcomes for patients. Genomic profiling of tumors refractory to current FGFR inhibitors in the clinic has revealed several acquired driver alterations that could be the target of next generation therapeutics. Herein, we describe how structure-based drug design (SBDD) was used to enable the discovery of the potent and kinome selective pan-FGFR inhibitor KIN-3248, which is active against many acquired resistance mutations. KIN-3248 is currently in phase I clinical development for the treatment of advanced tumors harboring FGFR2 and/or FGFR3 gene alterations.