anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OARSCM (n = 51) patients will receive the same TAU procedures described above. They will also earn chances for prizes, with the same targeted behaviors, escalation of chances for prizes for each targeted behavior in a row, and reset criteria described. Briefly, for scheduling a MOUD treatment intake, patients will earn 2 chances for prizes. Chances for prizes will increase by 2 chances with documentation of each targeted behavior in a row up to a maximum of 10 draws/targeted behavior. With 38 targeted behaviors (schedule MOUD intake, complete intake, 12 opioid-negative urine toxicology/week over 12 weeks plus bonuses for cocaine-negative tests, and 12 group/individual therapy/week over 12 weeks), patients can earn up to 252 chances for prizes during the 12-week RCT.
Participants in the intervention group will receive the mobile application for improving symptoms and adherence to oral chemotherapy along with their standard oncology care. The proposed elements of the mobile application include the following: 1) specification of an oral chemotherapy treatment plan; 2) weekly collection of patient-reported symptoms and medication adherence; and 3) delivery of real-time, tailored feedback to patients as well as immediate transmission of survey results to oncology clinicians.
Approaches for detecting presence of ROP in an input eye, are described. In an example, an input eye image, corresponding to the input eye, is obtained. Once obtained, the input eye image may undergo a plurality of pre-processing steps including cropping, padding, resizing, and sharpening. Thereafter, the input eye image may be processed based on a view assessment model to select a temporal view image. Then, the input eye image may be processed based on a quality assessment module to ascertain the quality of the input eye image. Once the input eye image is ascertained to be acceptable based on quality standards, the same may be processed based on a categorization model to obtain attribute information to detect the presence of the ROP and performs binary categorization of the input eye image as one of a no referral ROP and a referral ROP.
The incidence of obesity has markedly increased globally over the last several decades and is believed to be associated with the easier availability of energy-dense foods, including high-fat foods. The reinforcing hedonic properties of high-fat foods, including olfactory cues, activate reward centers in the brain, motivating eating behavior. Thus, there is a growing interest in the understanding of the genetic changes that occur in the brain that are associated with obesity and eating behavior. This growing interest has paralleled advances in genomic methods that enable transcriptomic-wide analyses. Here, we examined the transcriptomic-level differences in the olfactory bulb and striatum, regions of the brain associated with olfaction and hedonic food-seeking, respectively, in high-fat-diet (HFD)-fed obese mice. To isolate the dietary effects from obesity, we also examined transcriptomic changes in normal-chow-fed and limited-HFD-fed groups, with the latter being pair-fed with an HFD isocaloric to the consumption of the normal-chow-fed mice. Using RNA sequencing, we identified 274 differentially expressed genes (DEGs) in the striatum and 11 in the olfactory bulb of ad libitum HFD-fed mice compared to the chow-fed group, and thirty-eight DEGs in the striatum between the ad libitum HFD and limited-HFD-fed groups. The DEGs in both tissues were associated with inflammation and immune-related pathways, including oxidative stress and immune function, and with mitochondrial dysfunction and reward pathways in the striatum. These results shed light on potential obesity-associated genes in these regions of the brain.
The invention discloses a plaster for treating facioplegia and an acupuncture point applying method thereof. The plaster for treating the facioplegia is prepared from the following Chinese medicament in part by weight: 20 parts of castor bean seed, 3 parts of borneol and 5 parts of processed nux vomica. The three kinds of Chinese medicament are prepared into the plaster convenient to be applied by the prior general preparation process; and net weight of each plaster is 0.5g. A using method of the plaster comprises the following steps of: applying the plaster having the net weight of 0.5g on temple point, Xiaguan point, Jiache point and Dicang point of a patient respectively; and changing the plaster every five days until curing. The plaster has the effects of opening orifices and rousing spirit, and clearing heat and relieving pain. The finished product of the plaster only acts on relevant acupuncture points of the patient. Therefore, the plaster has the advantages of quick response, convenient use, no toxic or side effect and low treatment cost.
The invention discloses the use of cactus pear fruit polysaccharides extracted from cactus pear fruit in the preparation of medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors. The cactus pear fruit polysaccharides can control the occurrence and development of hypertension, have an active significance for preventing the occurrence and development of hyperlipidemia and fatty degeneration of liver, have potential applications in the prevention and treatment of diabetes and complications and have certain antitumor effect. Therefore, the invention lays a foundation for the development of medicaments or health-care products for preventing and treating hypertension, hyperlipaemia and diabetes and resisting tumors, and promotes the full use of the cactus pear fruit polysaccharides effectively. The cactus pear fruit is a natural plant resource with remarkable medicinal and health-care effects as well as regulation and protection effects on human organs and systems. The price of the cactus pear fruit is relatively low, and the side effects of the cactus pear fruit are relatively fewer. Thus, the cactus pear fruit polysaccharides have good application prospect in the preparation of the medicaments or health-care products for reducing blood pressure, blood fat, blood sugar and resisting tumors.
Subacute spinal cord injury (SCI) displays a complex pathophysiology associated with pro-inflammation and ensuing tissue damage. Microglia, the resident innate immune cells of the CNS, in concert with infiltrating macrophages, are the primary contributors to SCI-induced inflammation. However, subpopulations of activated microglia can also possess immunomodulatory activities that are essential for tissue remodeling and repair, including the production of anti-inflammatory cytokines and growth factors that are vital for SCI recovery. Recently, reports have provided convincing evidence that sex-dependent differences exist in how microglia function during CNS pathologies and the extent to which these cells contribute to neurorepair and endogenous recovery. Herein we employed flow cytometry and immunohistochemical methods to characterize the phenotype and population dynamics of activated innate immune cells within the injured spinal cord of age-matched male and female rats within the first week (7 days) following thoracic SCI contusion. This assessment included the analysis of pro- and anti-inflammatory markers, as well as the expression of critical immunomodulatory kinases, including P38 MAPK, and transcription factors, such as NFκB, which play pivotal roles in injury-induced inflammation. We demonstrate that activated microglia from the injured spinal cord of female rats exhibited a significantly diminutive pro-inflammatory response, but enhanced anti-inflammatory activity compared to males. These changes included lower levels of iNOS and TLR4 expression but increased levels of ARG-1 and CD68 in females after SCI. The altered expression of these markers is indicative of a disparate secretome between the microglia of males and females after SCI and that the female microglia possesses higher phagocytic capabilities (increased CD68). The examination of immunoregulatory kinases and transcription factors revealed that female microglia had higher levels of phosphorylated P38Thr180/Tyr182 MAPK and nuclear NFκB pp50Ser337 but lower amounts of nuclear NFκB pp65Ser536, suggestive of an attenuated pro-inflammatory phenotype in females compared to males after SCI. Collectively, this work provides novel insight into some of the sex disparities that exist in the innate immune response after SCI and indicates that sex is an important variable when designing and testing new therapeutic interventions or interpretating positive or negative responses to an intervention.
CR is a form of group therapy that uses a hybrid approach of restorative and strategy based methods to improve areas of cognition (ie. attention, memory, processing speed and learning) through the use of computerized exercises. CR is administered in groups consisting of 2-8 participants and one or two therapists. The CR groups meet twice per week for two hours per session over twelve weeks, for a total of 24 sessions.
Skeletal muscle dysfunction is common in patients with COPD and has been recognized as a contributing factor to reduced exercise capacity, health related quality of life and increased mortality associated with this disease. Several structural changes in the limb muscles of patients have previously been reported and have been linked to the known reductions in muscle strength and endurance commonly reported in COPD. Muscle dysfunction, lower extremity muscle strength, and muscle fatigue also contribute to the intensity of dyspnea and the ability to sustain exercise mostly through stimulation of type III and IV muscle afferents. As such, many patients who primarily perform aerobic exercise training as part of pulmonary rehabilitation are unable to tolerate the intensity and/or volume of exercise required to achieve clinically important changes in exercise capacity or symptom relief. Resistance training (RT) is an attractive exercise modality for patients with COPD because it is efficacious and often more tolerable initially. To our knowledge no one has examined whether similar benefits to those elicited by longer RT programs can be attained in just 4 weeks using multi-joint, multi-muscle exercises and individualized progression. If a short term RT program can improve muscle quality, enhance endurance, and reduce type III and IV afferent activity then it would reduce the drive to breathe and thus dyspnea. These adaptations would likely translate into improved exercise tolerance making it feasible to "pre-habilitate" COPD patients with tolerable RT, allowing them to achieve a higher volume/intensity of endurance training, thus making pulmonary rehabilitation more effective.
PURPOSE:To obtain a scrub cleaning agent having adequate hardness and good use feeling and optimum for comerdo by blending scrub agent granules with a cleaner. CONSTITUTION:A scrub agent is shaped into fine powder having <=20mum average particle size and then formed into granules having 0.2-3mm average particle size using a water-soluble binder (e.g. hydroxypropylcellulose). The granules are mixed with powder or granules of the cleaner and as necessary conventional pigment is properly blended therewith and prepared to provide the objective product. When the pigment is previously added to scrub fine powder, beautiful appearance is exhibited and in collapse of the granules, color disappears and end of scrub effect can be clearly found. Pearl layer powder, polyethylene powder, conchyolin powder, etc., is used as the scrub agent powder.
Problem gambling and problem drinking frequently co-occur. Further, the treatment needs of people with co-occurring gambling and drinking problems may be different from those of problem gamblers who do not drink alcohol in a hazardous fashion. The current project will evaluate whether there is a benefit to providing access to a problem drinking Internet intervention (G+A intervention) in addition to an Internet intervention for problem gambling (G-only intervention) in participants with gambling problems who do or do not have co-occurring problem drinking.

People with gambling concerns will be recruited using targeted advertisements. Potential participants will be screened using an online survey to identify participants meeting criteria for problem gambling. As part of the baseline screening process, measures of alcohol consumption will be assessed. Eligible participants who agree to take part in the study will be randomized into one of two online interventions for gamblers - an intervention that only targets gambling issues (G-only) versus one that contains an intervention for drinking (G+A). It is predicted that for problem gamblers with co-occurring problem drinking, participants provided access to the G+A website will display significantly reduced gambling outcomes at three- and six-month follow-ups as compared to those provided access to the G-only website. However, for problem gamblers without co-occurring problem drinking, it is predicted that participants will display no significant difference between the G-only and G+A websites at three- and six-month follow-ups.
The present invention relates to a Chinese medical preparation for treating wind-cold type of common cold and a preparing method thereof. Indian kalimeris herb is pulverized to fine powder, and effective ingredients of fewflower lysionotus herb, wintersweet root or stem, aleppo avens, mysorethorn bark, perilla leaf and schizonepeta are extracted by a water technique or an ethanol technique. Then, the effective ingredients are uniformly mixed with Indian kalimeris herb fine powder, dried, pulverized and made into a required dosage form. Compared with the prior art, the present invention is made from pure Chinese herbal medicine, the curative effect is obvious, and the present invention has no toxic side effect. Simultaneously, the present invention has the advantages of no somnolence ingredient in the medicine, low cost, simple preparation method and easy accepting by patients. The medicine has the efficiency of dispelling the evil in the superficies with drugs of pungent taste and warming nature, diffusing the lung and relieving a cough. The present invention is used for treating symptoms of headache because of wind-cold type of common cold, fever with aversion to cold, rhinorrhea, cough, etc. The medicine obtains the production permit of relevant departments of China.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to therapeutic dentistry, and can be used for the local treatment of chronic gingivitis caused by tobacco smoking in young individuals. That is ensured by a preparatory procedure of luminal-dependent chemiluminescence of the oral fluid aiming at a maximum burst and a glow light sum. If the maximum burst falls within the range of 3.3 to 18.15 standard units, whereas the glow light sum ranges from 8.2 to 40 standard units, an antioxidant therapy is conducted by using a transverse gingival mucosa electrophoresis on 5% aqueous propolis by means of jaw electrodes in a tray at a current intensity of 0.5-1 mA and an exposure of 8-10 minutes. A polarity is alternated with a positive pole to be taken the first. The therapeutic course makes 4 procedures every second day. Colgate Propolis Toothpase and Mouthwash are used additionally during 30 days. If the maximum burst is from 0.8 to 1.24 standard units, whereas the glow light sum ranges from 3.34 to 7.5 standard units, a pro-oxidant therapy is required by using an exposure to magnetic infrared laser (MIL) light covering a projection of gums and generated by Optodan laser with a periodontal attachment The exposure parameters: 2-2,000 Hz in segments, 2 minutes per each segment, no more than 12 minutes per 1 procedure. The therapeutic course makes 4 procedures every second day. Parodontax Toothpase and Mouthwash are used additionally during 12 days.EFFECT: method simplifies and reduces the length of the treatment in the given category of patients.2 ex
Denticleless E3 ubiquitin protein ligase homolog (DTL), the substrate receptor of the CRL4A complex, plays a central role in genome stability. Even though the oncogenic function of DTL has been investigated in several cancers, its specific role in hepatocellular carcinoma (HCC) still needs further elucidation. Data from a clinical cohort (n = 209), RNA-sequencing, and public database (TCGA and GEO) were analyzed, indicating that DTL is closely related to patient prognosis and could serve as a promising prognostic indicator in HCC. Functionally, DTL promoted the proliferation, metastasis, and sorafenib resistance of HCC in vitro. In the orthotopic tumor transplantation and tail vein injection model, DTL promoted the growth and metastasis of HCC in vivo. Mechanically, we revealed for the first time that DTL was transcriptionally activated by hypoxia-inducible factor 1α (HIF-1α) under hypoxia and functioned as a downstream effector molecule of HIF-1α. DTL promotes the ubiquitination of SAFB-like transcription modulator (SLTM) and subsequently relieves the transcriptional repression of Notch1. These results suggested that DTL may be a potential biomarker and therapeutic target for HCC.
Recent statistics found the prevalence of dyslexia in UK medical schools to be 7%, sitting below the national prevalence of 10%. The factors contributing to this discrepancy are currently unknown, but may result from an interplay of individual and systemic barriers to entering medicine. This collaborative, analytic autoethnography aimed to use the experiences of 'Meg', a fourth-year medical student who was diagnosed as dyslexic whilst at medical school, to explore how the lack of a diagnosis during the admissions process may have impacted her journey into medicine. The data were collected using reflective writing and an interview before conducting a thematic analysis. Our analysis resulted in the construction of two meta-themes, relating to the negative emotional impact of not having a diagnosis and feelings of inferiority. Seven themes were also constructed. Some explored how Meg's personal experience of undiagnosed dyslexia acted as a barrier to entering medicine. Others explored the impact of external factors, such as socio-economic background and the provision of support, on an individual's chance of successfully applying to medical school. Finally, we explored the inadvertent impact undiagnosed (and unrecognised) dyslexia had on Meg's life course, including how medicine-specific aptitude tests, such as the BMAT and UKCAT, may have contributed to this. These results provide a unique window into the culture of applying to medical school as an undiagnosed dyslexic person, whilst discussing the need for medical schools to consider how their admissions processes may inadvertently disadvantage undiagnosed dyslexic applicants.
VFEND I.V. for Injection unreconstituted vials should be stored at 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. VFEND is a single dose unpreserved sterile lyophile. From a microbiological point of view, following reconstitution of the lyophile with Water for Injection, the reconstituted solution should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and should not be longer than 24 hours at 2°C to 8°C (36°F to 46°F). Chemical and physical in-use stability has been demonstrated for 24 hours at 2°C to 8°C (36°F to 46°F). This medicinal product is for single use only and any unused solution should be discarded. Only clear solutions without particles should be used [see Dosage and Administration (2.1)].
1. A monoclonal antibody S19 expressed by the hybridoma deposit accessible under Access No. ATCC HB 12144, specific to a sperm surface glycoprotein SAGA-1. 2. A purified preparation of a sperm surface SAGA-1glycoprotein bound by the monoclonal antibody of Claim 1. 3. A contraceptive vaccine, comprising an amount of the sperm surface glycoprotein of Claim 2 in an amount effective to induce production of antibodies thereto when administered to a female mammal, in a pharmaceutically acceptable carrier. 4. The vaccine of Claim 3, wherein said glycoprotein is present in sufficient amounts such that, on completion of a vaccination protocol, said female mammal exhibits an antibody titer sufficiently high to provide at least 95 percent fertility inhibition. 5. A method for determining the antibody titer in a vaccination patient receiving the vaccine of Claim 3, comprising mixing a sample received from said vaccination patient with bound glycoprotein SAGA-1, bound on a solid matrix, and detecting binding between the glycoprotein SAGA-1, bound on a solid vehicle, and antigens present in the sample, wherein complete binding of all said bound glycoprotein is indicative of an antibody titer in said sample sufficient to inhibit fertilization in said patient. 6. A spermicide, comprising as an active agent the monoclonal antibody of Claim 1, in a pharmaceutically acceptable carrier. 7. The spermicide of Claim 6, wherein said spermicide comprises a concentration of monoclonal antibodies sufficient such that one dose of said spermicide effectively binds 100 percent of all sperm cells present in an ejaculate. 8. The spermicide of Claim 7, wherein said spermicide is prepared in the form of liposomes. 9. The spermicide of Claim 8, wherein said liposomes are non-phospholipid positively charged liposomes. 10. A method for determining the antibody titer in a vaccination patient receiving the vaccine of Claim 3, comprising mixing a sample received from said vaccination patient with glycoprotein SAGA-1 and measuring an amount of antibody in said sample, which is bound to the with glycoprotein SAGA-1.
FIELD: medicine, veterinary science. ^ SUBSTANCE: invention relates to commercial poultry production. A method involves treatment of surface of incubator zootechnical control objects and hatchable eggs with an aqueous solution of a quaternary ammonium compound preparation. The aqueous solution of the quaternary ammonium compound preparation is 0.05-0.1 % aqueous solution of a composition containing ammonium bromide trimethyloctadecyl - 80 % and ammonium iodide trimethyloctadecyl - 20 %. ^ EFFECT: method provides higher young poultry brood and safety. ^ 1 tbl, 1 ex
NEW MATERIAL:A compound expressed by the formula. USE:An antitumor agent of carcinogenesis inhibiting agent having antitumor activity and protein kinase C inhibiting activity. PREPARATION:UCN-1028C producing bacterium strain belonging to the genus Cladosporium is subjected to liquid cultivation in a culture medium containing a carbon source, nitrogen source, etc., at 20-35 deg.C and pH 4-10 for 1-7 days. Then the culture liquid is filtered to afford bacterium cell, which is extracted with acetone, etc. and purified by applying the extract to a nonionic porous resin column, silica gel column or Sephadex column to provide the compound expressed by the formula. Properties of the compound expressed by the formula; molecular formula, C44H38O14; molecular weight, 790; solubility, insoluble in water, soluble in alkali water, chloroform, acetone, ethyl acetate and readily soluble in methanol and DMSO.