anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
After enrollments, subjects were assigned to perform mental fatigue-inducing experiment-a 90 min of monotonous simulated driving task. They underwent repeated measurements of quantitative pupillary light reflex (PLR) using an automated quantitative pupillometer at baseline and at an interval of 30 min during the task. Subjective ratings, heart rate variability (HRV), and electroencephalography (EEG) were performed simultaneously.
Nimodipine plasma concentration and efficacy may be significantly reduced when concomitantly administered with strong CYP3A4 inducers. Therefore strong CYP3A4 inducers (e.g. rifampin, carbamazepine, phenobarbital, phenytoin, St. John’s Wort) should generally not be administered concomitantly with nimodipine (see WARNINGS). 

Other moderate and weak inducers of CYP3A4 may also reduce the efficacy of nimodipine, although the magnitude of decrease in nimodipine plasma concentrations is not known. Patients on these should be closely monitored for lack of effectiveness, and a nimodipine dosage increase may be required. Moderate and weak CYP3A4 inducers include: amprenavir, aprepitant, armodafinil, bosentan, efavirenz, etravirine, Echinacea, modafinil, nafcillin, pioglitazone, prednisone and rufinamide.
Process for preventing microorganisms, such as, mold, fungi, bacteria, and/or virus, from attaching to a surface. The microorganism and/or the surface are treated with an effective amount of a solution. The solution has the property of being antimicrobial. The solution contains an effective amount of a non-necrotic sclerosing fatty acid salt, an effective amount of ethanol, a buffering agent and a water carrier. The fatty acid salt is one prepared from an unsaturated fatty acid having one double bond and from an alkali metal, alkaline earth metal, alkali metal compound or alkaline earth metal compound. The pH of the solution is between 9 and 11.
Aim 1 involves the prospective data collection of subjects who are already enrolled in Mayo Clinic Rochester research study 08-005553 (PI: Dr Val Lowe) and are scheduled to be scanned on the Siemens Biograph Vision 600 PET/CT system (hereafter referred to as the V600-R1) in the PET/CT Molecular Imaging Research Center on Charlton 6 of Mayo Clinic Rochester. The purpose of this arm is to evaluate the effectiveness of motion correction software.
RO7623066 will be administered orally once daily (QD) continuously as monotherapy. Once the maximum tolerated dose (MTD) for RO7623066 monotherapy has been reached this concludes the Dose Escalation phase.
PURPOSE: Metabolic vulnerabilities can exacerbate inflammatory injury and inhibit repair in multiple sclerosis (MS). The purpose was to evaluate whether blood biomarkers of inflammatory and metabolic vulnerability are associated with MS disability and neurodegeneration.
METHODS: Proton nuclear magnetic resonance spectra were obtained from serum samples from 153 healthy controls, 187 relapsing-remitting, and 91 progressive MS patients. The spectra were analyzed to obtain concentrations of lipoprotein sub-classes, glycated acute-phase proteins, and small-molecule metabolites, including leucine, valine, isoleucine, alanine, and citrate. Composite indices for inflammatory vulnerability, metabolic malnutrition, and metabolic vulnerability were computed. MS disability was measured on the Expanded Disability Status Scale. MRI measures of lesions and whole-brain and tissue-specific volumes were acquired.
RESULTS: Valine, leucine, isoleucine, alanine, the Inflammatory Vulnerability Index, the Metabolic Malnutrition Index, and the Metabolic Vulnerability Index differed between healthy control and MS groups in regression analyses adjusted for age, sex, and body mass index. The Expanded Disability Status Scale was associated with small HDL particle levels, inflammatory vulnerability, and metabolic vulnerability. Timed ambulation was associated with inflammatory vulnerability and metabolic vulnerability. Greater metabolic vulnerability and inflammatory vulnerability were associated with lower gray matter, deep gray matter volumes, and greater lateral ventricle volume.
CONCLUSIONS: Serum-biomarker-derived indices of inflammatory and metabolic vulnerability are associated with disability and neurodegeneration in MS.
During the post approval use of azelastine hydrochloride 0.15%, the following adverse reactions have been identified. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse reactions reported include: abdominal pain, atrial fibrillation, blurred vision, chest pain, confusion, disturbance or loss of sense of smell and/or taste, dizziness, dyspnea, facial swelling, hypertension, involuntary muscle contractions, nasal burning, nausea, nervousness, palpitations, paresthesia, parosmia, pruritus, rash, sneezing, insomnia, sweet taste, tachycardia, and throat irritation.

Additionally, the following adverse reactions have been identified during the post approval use of the Astelin brand of azelastine hydrochloride 0.1% nasal spray (total daily dose 0.55 mg to 1.1 mg). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Adverse reactions reported include the following: anaphylactoid reaction, application site irritation, facial edema, paroxysmal sneezing, tolerance, urinary retention, and xerophthalmia.
Hepatic ischaemia-reperfusion (I/R) injury is a frequent and nearly inevitable pathophysiological process without widely accepted effective therapy. Soluble egg antigen (SEA) of Schistosoma japonicum (S. japonicum) is the main mediators capable of regulating immunological activities and has received increased attention in immune-mediated diseases. But its role in hepatic I/R injury has not been well defined. This study aimed to elucidate whether SEA protects liver against hepatic I/R injury and explore underlying mechanism. After intraperitoneal injecting SEA three times a week for 4 weeks, mice underwent 70% hepatic I/R injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), haematoxylin-eosin (HE) and TdT-mediated dUTP nick-end labelling (TUNEL) staining were used to evaluate liver injury. The severity related to the inflammatory response was also investigated. Furthermore, immunofluorescence was used to detect macrophage polarisation. Compared with the hepatic I/R injury group, SEA pretreatment significantly alleviated hepatic I/R injury induced liver damage, apoptosis and inflammatory. Interestingly, SEA enhanced the polarisation of macrophages towards M2 macrophages in vivo. We are the first to investigate the therapeutic efficacy of S. japonicum SEA in a hepatic I/R injury model in mice. We provided the first direct evidence that SEA attenuated hepatic I/R injury by promoting M2 macrophage polarisation.
Stage B: Vehicle nasal spray, 1 spray to each nostril twice a day for 4 days. On Day 5, 1 spray to each nostril 60 minutes before entering the EEC.
Neuronal ensemble activity entrained by local field potential (LFP) patterns underlies a variety of brain functions, including emotion, cognition, and pain perception. Recent advances in machine learning approaches may enable more effective methods for analyzing LFP patterns across multiple brain areas than conventional time-frequency analysis. In this study, we tested the performance of two machine learning algorithms, AlexNet and the Transformer models, to classify LFP patterns in eight pain-related brain regions before and during acetic acid-induced visceral pain behaviors. Over short time windows lasting several seconds, applying AlexNet to LFP power datasets, but not to raw time-series LFP traces from multiple brain areas, successfully achieved superior classification performance compared with simple LFP power analysis. Furthermore, applying the Transformer directly to the raw LFP traces achieved significantly superior classification performance than AlexNet when using LFP power datasets. These results demonstrate the utility of the Transformer in the analysis of neurophysiological signals, and pave the way for its future applications in the decoding of more complex neuronal activity patterns.
After Ethics committee approval, investigators decided to enroll 40 pateints ASA I-II, 18-60 years of age undergoing maxillofascial, oral and double chin surgery to determine which nostril is more suitable for nasotracheal intubation with nasotracheal Airtraq. In addition is the 90° anti-clockwise rotation of the tip of the tube helpful to insert the tube into the trachea. Patients were randomized into right and the left nostril groups. After standard anesthesia induction with propofol and fentanyl, rocuronium was used for muscle relaxation. Primary aim of this prospective study was to compare the glottis visualization time, intubation time and total intubation times. The Cormack-Lehane grades, the need for optimization, tube adjustment maneuvers, hemodynamic data, occurrence of epistaxis of the patients were recorded during the process.
FIELD: antlers-type reindeer breeding, pharmaceutics. SUBSTANCE: the suggested method deals with applying clay onto antlers' section, thermal treatment and wind drying, moreover, one should apply clay at moisture of not more than 20% without any calcination. Before thermal treatment velvet antlers undergo freezing from -4 to -15 C for 10-15 d, thermal treatment with infrared beams should be conducted at emission spectrum being 1.5-2.8 mcm and 65-68 C to achieve antlers' moisture of 16-17%. The present innovation provides high quality of raw material and decreased financial and labor resources. EFFECT: higher efficiency of conservation. 1 ex, 5 tbl _
Mechanical force induces hypoxia in the pulpal area by compressing the apical blood vessels of the pulp, triggering pulpal inflammation during orthodontic tooth movement. However, this inflammation tends to be restorable. Macrophages are recognized as pivotal immunoreactive cells in the dental pulp. Whether they are involved in the resolution of pulpal inflammation in orthodontic teeth remains unclear. In this study, we investigated macrophage polarization and its effects during orthodontic tooth movement. It was demonstrated that macrophages within the dental pulp polarized to M2 type and actively participated in the process of pulpal inflammation resolution. Inflammatory reactions were generated and vascularization occurred in the pulp during orthodontic tooth movement. Macrophages in orthodontic pulp show a tendency to polarize towards M2 type as a result of pulpal hypoxia. Furthermore, by blocking M2 polarization, we found that macrophage M2 polarization inhibits dental pulp-secreting inflammatory factors and enhances VEGF production. In conclusion, our findings suggest that macrophages promote pulpal inflammation resolution by enhancing M2 polarization and maintaining dental health during orthodontic tooth movement.
The exposure of interest is Dayingpian. Patients in this group take Dayingpian combined with conventional mood stabilizers. The psychiatrist does not assign specific interventions to the study participants. The course of observation is 12 weeks.
Tofacitinib will be self-administered for 6 months, with the option to extend treatment up to an additional 6 months at the discretion of the principal investigator. Patients will then be followed for 6 months off the drug to assess the incidence and timing of recurrence of disease or documentation of delayed response to treatment.
PURPOSE: To obtain the subject composition useful for household and industrial disinfectant, soap, etc., especially effective for sterilizing water in a cooling tower, etc., comprising an agent selected from a coal-derived humic acid, its salt and derivative and a carrier. CONSTITUTION: This composition comprises 4-25wt.% (preferably 4-17wt.%) of humic acid derived from oxidized coal, its salt or derivative as an agent. The coal-derived humic acid is composed of 45-70wt.% of carbon, 20-40wt.% of oxygen, 2-6wt.% of hydrogen, further <=5wt.% of sulfur and 1-2wt.% of nitrogen and is used with a liquid or solid carrier. An aqueous carrier is preferable as the liquid carrier. In this case, the medium has pH7-8.5 and the composition is preferably used for sterilizing water especially in a cooling tower or a cascade plate for passing water through the tower. The coal-derived humic acid is produced in a stable state more inexpensively than a humic acid derived from other natural resources and shows sterilizing effects in a low concentration.
PURPOSE: To obtain a hyaluronidase activity inhibitor or a humectant consisting essentially of a natural product having high hyaluronisase activity inhibitor action and extracted from fruit of Prunus domestica LINN. free from adverse effects and preventing activation of hyaluronidase, and a cosmetic containing the inhibitor and the humectant. CONSTITUTION: This hyaluronidase activity inhibitor or this humectant contains an extract extracted from fresh fruit or dried fruit of Prunus domestica LINN. by an extraction means using a hydrophilic solvent such as water, cold water, hot water, ethyl alcohol or glycerin or a mixed liquid of a polyhydric alcohol with water as an active ingredient. This cosmetic contains the hyaluronidase activity inhibitor and the humectant. The extract is used as the hyaluronidase activity inhibitor or the humectant directly or in diluted or condensed state or in a form of concentrated and dried or lyophilized powder or granule or tablet or used by adding these materials to a cosmetic.
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy (see INDICATIONS). It is 3-mercapto-D-valine. It is a white or practically white, crystalline powder, freely soluble in water, slightly soluble in alcohol, and insoluble in ether, acetone, benzene, and carbon tetrachloride. Although its configuration is D, it is levorotatory as usually measured: 

calculated on a dried basis.

The molecular formula is C5H11NO2S, giving it a molecular weight of 149.21 g/mol. The structural formula is:

It reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic acid. Penicillamine capsules for oral administration contain 250 mg of penicillamine. Each capsule contains the following inactive ingredients: magnesium stearate, microcrystalline cellulose. The capsule shell contains black pharmaceutical ink, D&C yellow #10, gelatin and titanium dioxide. The capsule imprinting black ink contains ammonium hydroxide 28%, iron oxide black, propylene glycol and shellac.
How Supplied

APRETUDE is supplied in a kit containing one 600-mg/3-mL single-dose (200-mg/mL) vial of cabotegravir extended-release injectable suspension, 1 syringe, 1 vial adapter, and 1 needle for intramuscular injection (23 gauge, 1½ inch) (NDC 49702-264-23). The vial stopper is not made with natural rubber latex.

Storage and Handling

Store APRETUDE at 2°C to 25°C (36°F to 77°F) in the original carton until ready to use. Exposure up to 30°C permitted. Do not freeze. Do not mix with any other product or diluent.

If the pack has been stored in the refrigerator, the vial should be brought to room temperature prior to administration (not to exceed 30°C [86°F]). 

Once the suspension has been drawn into the syringe, the injection should be administered as soon as possible, but may remain in the syringe for up to 2 hours. The filled syringes should not be placed in the refrigerator. If the medicine remains in the syringe for more than 2 hours, the filled syringe and needle must be discarded [see Dosage and Administration (2.7)].
The liver, with its ability to produce acute phase proteins, complement and cytokines, plays a central role in regulating inflammation. A balanced pro- and anti-inflammatory liver response results in bacterial clearance and resolution of inflammation. Steatotic liver disease (SLD) is the most common chronic liver disease associated with systemic changes in immune response. Although there are numerous immunological links between sepsis and SLD, there is a significant gap in knowledge regarding the role of SLD in sepsis. Semaphorins were recently recognized as one of the key regulators of immune responses; while some suppress immune cells activation, proliferation and production of inflammatory cytokines, others stimulate immune responses. Semaphorins were recently shown to be associated with pathogenesis of viral hepatitis, SLD and progression of fibrosis. However, their role in sepsis is unknown. The hypothesis of this project is that semaphorins are regulators of inflammation in patients with SLD that have impact on sepsis outcome.
The invention discloses improved polarizing liquor and a preparation method as well as application thereof. The composition of the improved polarizing liquor comprises the following components: 50-200 g/L of fructose, 50-200 g/L of glucose, 30-70 U/L of insulin and 50-100 mmol/L of potassium chloride, wherein the solvent is water for injection. The preparation method comprises the following steps: taking the fructose, the glucose and the potassium chloride, adding the water for injection for dissolving, removing pyrogen, sterilizing and drying to prepare a medicinal mixture component A; taking the medicinal component B constituted by the insulin independently; adding the medicinal component B into the medicinal mixture component A to prepare the improved polarizing liquor. According to the improved polarizing liquor (FGIK), the oxidative stress of liver and kidney tissues after trauma can be relieved, and the polarizing liquor has a certain anti-oxidation effect. The FGIK can be used for adjuvant therapy for protection of functions of important organs after trauma, and has potential broader application prospect. Thus, the polarizing liquor can be applied to preparing a medicament for liver and/or kidney tissue repair after trauma or operation.
PURPOSE: To observe the regulation of cerebral circulation in vivo based on image segmentation algorithms for deep learning in medical imaging to automatically detect and quantify the neonatal deep medullary veins (DMVs) on susceptibility weighted imaging (SWI) images. To evaluate early cerebral circulation self-rescue for neonates undergoing risk of cerebral hypoxia-ischaemia in vivo.
METHODS: SWI images and clinical data of 317 neonates with or without risk of cerebral hypoxia-ischaemia were analyzed. Quantitative parameters showing the number, width, and curvature of DMVs were obtained using an image segmentation algorithm.
RESULTS: The number of DMVs was greater in males than in females (p < 0.01), and in term than in preterm infants (p = 0.001). The width of DMVs was greater in term than in preterm infants (p < 0.01), in low-risk than in high-risk group (p < 0.01), and in neonates without intracranial extracerebral haemorrhage (ICECH) than with ICECH (p < 0.05). The curvature of DMVs was greater in term than in preterm infants (P < 0.05). The width of both bilateral thalamic veins and anterior caudate nucleus veins were positively correlated with the number of DMVs; the width of bilateral thalamic veins was positively correlated with the width of DMVs.
CONCLUSION: The DMVs quantification based on image segmentation algorithm may provide more detailed and stable quantitative information in neonate. SWI vein quantification may be an observable indicator for in vivo assessment of cerebral circulation self-regulation in neonatal hypoxic-ischemic brain injury.
Hypertension

Of the total number of subjects in clinical studies of ATACAND, 21% (683/3260) were 65 and over, while 3% (87/3260) were 75 and over. No overall differences in safety or effectiveness were observed between these subjects and younger adult subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. In a placebo-controlled trial of about 200 elderly hypertensive patients (ages 65 to 87 years), administration of candesartan cilexetil was well tolerated and lowered blood pressure by about 12/6 mm Hg more than placebo.

Heart Failure

Of the 7599 patients with heart failure in the CHARM program, 4343 (57%) were age 65 years or older and 1736 (23%) were 75 years or older. In patients ≥ 75 years of age, the incidence of drug discontinuations due to adverse events was higher for those treated with ATACAND or placebo compared with patients <75 years of age. In these patients, the most common adverse events leading to drug discontinuation at an incidence of at least 3%, and more frequent with ATACAND than placebo, were abnormal renal function (7.9% vs. 4.0%), hypotension (5.2% vs. 3.2%) and hyperkalemia (4.2% vs. 0.9%). In addition to monitoring of serum creatinine, potassium, and blood pressure during dose escalation and periodically thereafter, greater sensitivity of some older individuals with heart failure must be considered.
The present invention has the goal of providing externally used traditional Chinese medicine for radically treating tympanitis, which has a short medication period and a conspicuous curative effect. The traditional Chinese medicine has raw materials as following: juice of fresh calamus, distilled water and white sugar, wherein the content of the juice of fresh calamus is at least 95%. The present invention creatively uses the pharmaco-medicine performance of the fresh calamus. The fresh juice squeezed by fresh calamus roots is regarded as major ingredients, and a proper amount of the distilled water is added for dilution so that the viscosity of the fresh juice is decreased. Meanwhile, a proper amount of the white sugar is added for blending so that foreign flavors are reduced. Then, the fresh juice is directly applied on a focus. An effect is obvious particularly for otitis media suppurativa. A total effective rate is 100%., and a cure rate achieves 98% by clinical application. The present invention has no toxic or side effect.
PROBLEM TO BE SOLVED: To obtain the subject non-sticky composition having a moisture- imparting characteristic by compounding an alcohol, a carbomer polymer, a cationic antimicrobial compound, and water. SOLUTION: An antimicrobial composition having a viscosity of >5,000 centipoises comprises (A) >=40 wt.% of an alcohol, (B) an effective amount of a carbomer polymer, (C) an effective amount of a cationic antimicrobial compound (for example, benzethonium chloride), and (D) water. The composition may further be compounded with a complexing agent. The remainder of the composition is 15-40 wt.% of water. The component A includes n-propyl alcohol and isopropyl alcohol, and is preferably used in a concentration of 60-75 vol.%. The concentration of the component C in the whole composition is preferably 0.09-0.2 wt.%, and the concentration of the component B is preferably 0.4-0.7 wt.%.