anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Although Zika virus infection is rarely reported now, continuous prevention is needed to achieve sustained eradication. This study aimed to explore the knowledge gaps, risk perception and preventive measures against Zika virus infection (ZIKV) in pregnant women in Malaysia.
METHODS: We conducted in-depth virtual interviews with pregnant women between February and April 2022. The interviews were recorded and transcribed, and data were analyzed by content analysis.
RESULTS: The majority of the participants demonstrated a commendable level of awareness regarding the signs and symptoms associated with ZIKV infection. They also exhibited a clear understanding of preventive measures, particularly emphasizing the importance of avoiding mosquito bites to minimize the risk of ZIKV transmission. However, a noteworthy gap in knowledge surfaced as a subset of participants remained uninformed about the potential for sexual transmission of ZIKV, which could lead to congenital ZIKV in pregnant women. Even among women who were cognizant of ZIKV and its potential negative health outcomes, associated with the infection, many of them did not perceive themselves to be at risk, mainly because ZIKV infection is infrequently discussed or heard of, leading to a sense of infections' rarity. While the adoption of preventive measures such as mosquito bite prevention during pregnancy was a common practice, however, prevention of sexually transmitted infections (STIs) including mosquito-borne diseases such as Zika is low. A minority of women express concerns about the sensitivity surrounding discussions and prevention of STIs within the context of marriage. Most of the participants were supportive of the provision of awareness of ZIKV infection in women during pregnancy and the involvement of men, especially in initiatives aimed at preventing transmission through sexual contact.
CONCLUSION: This study uncovered gaps in both knowledge and practices pertaining ZIKV infection among pregnant women in the aftermath of the ZIKV pandemic. The insights gleaned from our research are valuable for shaping future interventions geared towards preventing the resurgence or facilitating the sustainable eradication of ZIKV.
Usual diabetes care, every 3 months for 12 months, which consists of visits with their diabetes care physician. In addition, as per usual diabetes care, an individual education session and written information will be provided before formal transfer.
The aim of this study was to increase the bioconversion efficiency (lipid accumulation) of black soldier fly larvae while simultaneously increasing biodiesel production through a feed-shifting strategy. Feeding with low-lipid feed promoted an increase in larval weight, while high-lipid feed resulted in greater lipid accumulation. Based on this result, a feed-shifting strategy was introduced, which consisted of two stages: first, increasing larval body weight using low-lipid feed, followed by lipid induction for biodiesel production using high-lipid feed. The use of this strategy resulted in an increase in the dry weight of larvae by ≥16 % compared to single feeding systems. This led to a 20 % increase in biodiesel productivity. The waste reduction ratio was enhanced due to the higher bioconversion rate in the feed-shifting strategy compared to that in the single feeding systems. The feed-shifting strategy would contribute to the enhancement of waste-to-energy efficiency.
Background and Objectives: This study aimed to investigate the relationship between lower urinary tract symptoms (LUTS) and tooth loss due to chronic periodontitis. Materials and Methods: A total of 232 patients aged 40 years or older with LUTS were evaluated. The number of remaining teeth and the severity of LUTS were assessed using the overactive bladder symptom score, international prostate symptom score, and urodynamic tests. Statistical analyses, including multivariate and propensity score matching, were conducted to determine the relationship between tooth loss and overactive bladder (OAB). Results: Compared with the non-OAB group, the OAB group had significantly fewer remaining teeth (p < 0.001). A negative correlation was observed between the number of remaining teeth and the severity of LUTS, with symptoms such as urgency, frequency, and nocturia being more severe in patients with fewer teeth (all p < 0.001). Objective measures, including bladder capacity and maximum flow rate, were also significantly lower in patients with fewer teeth. Additionally, having fewer than 21 teeth was identified as a significant risk factor for LUTS. Multivariate analysis confirmed that tooth loss was an independent risk factor for OAB, even after adjusting for age and comorbidities (p < 0.001). Propensity score matching further validated the association between the number of remaining teeth and OAB (p = 0.022), highlighting a clear connection between dental health and urinary function. Conclusions: Tooth loss due to chronic periodontitis is strongly associated with the severity of LUTS, including storage and voiding symptoms. Maintaining good oral health may help reduce the risk of OAB and related urinary symptoms. This study underscores the importance of dental care in managing and preventing LUTS, suggesting that improving oral health could play a key role in mitigating these conditions.
The present invention discloses a traditional Chinese drug composition used for skin health care and an application method thereof, which belongs to a skin health care drug. The present invention is a prescription prepared from the following traditional Chinese drugs as raw materials of lightyellow sophora root, arnebia root, honeysuckle flower, mint, pepper, liquorice, fineleaf schizonepeta herb, ledebouriella root, weeping forsythia capsule, sodium sulfate, common cnidium fruit, radix isatidis, dyers woad leaf, dahurian angelica, argy wormwood leaf and dittany bark. The traditional Chinese drugs are respectively processed through drying, pulverization and porphyrization for achieving certain fineness, and effective components of the traditional Chinese drugs are respectively extracted with a traditional extraction method. Then, after being refined with a general method, extracting solutions refined from the traditional Chinese drugs are mixed according to proportioning, and penetrating agents are added. After being adsorbed by lacunaris non woven fabric with high water absorption, a mixed extracting solution is made into wet tissues. After being mixed according to the proportioning, comminuted drug powder can also be added with right amount of water and a small amount of penetrating agents for being prepared into drug face mask ointments. The wet tissues and the face mask ointments prepared through the prescription of the present invention has the effects of naturalness, no toxic and side effect, high efficiency, safety, etc., and are suitable for skin of various types and the cure of various skin diseases.
The present invention relates to an oil having gold (Au) nanoparticles distributed therein and a preparing method thereof. The gold (Au) nanoparticles included in the oil are in any one of the shapes of plate flakes, spheres, and polyhedrons. The size of the gold (Au) nanoparticles is 100 nm or less. The gold (Au) nanoparticles have the surface particles arranged in series to form multiple straight lines parallel to each other. Accordingly, the gold (Au) nanoparticles can be uniformly distributed in the oil to form smooth surfaces. The preparing method can be used to organically control the size of the gold (Au) nanoparticles. The gold (Au) nanoparticles with smooth surfaces can be uniformly distributed in the oil. The preparing method can have high productivity and cost-efficient preparing processes.
This study is a drug interaction study designed to study the effects of enalapril on doxorubicin metabolism. Women with breast cancer for whom at least two cycles every 14 day doxorubicin is planned will be considered for enrollment. Study participation will be for 2 treatment cycles of doxorubicin or approximately 4 weeks. Patients will receive a 14 day course of daily enalapril in association with one cycle of doxorubicin and receive no study agent during the other cycle allowing patients to act as their own control. The sequence of enalapril dosing will be assigned by randomization at study enrollment. Blood samples for pharmacokinetics will be drawn before and at 7 time points after each of the two doses of doxorubicin. For each patient, serum doxorubicin and doxorubicinol concentrations both on and off of enalapril will be compared.
Swallowing impairments are a common and a serious complication of stroke but lack effective therapies. The study investigators herein propose to conduct a prospective clinical study using a non-invasive brain stimulation technique, anodal transcranial direct current stimulation (tDCS), in combination with swallowing exercises for improving dysphagia due to an acute-subacute hemispheric infarction, and obtain data on safety and effect of 2 different doses of tDCS, on swallowing physiology and behavior. Dysphagia from hemispheric strokes occurs due to disruption of the cortical projections to the brainstem swallowing centers while recovery of swallowing functions have been shown to be mediated via the reorganization of the swallowing cortex in the unaffected hemisphere. A recent pilot study conducted by the investigators demonstrated the safety and feasibility of applying 5 consecutive daily sessions of anodal tDCS for 30 minutes to the swallowing cortex on the unaffected hemisphere in the acute-subacute stroke phases and showed a promise in improving dysphagia, when combined with swallowing exercises. The proposed research will be used to further confirm safety of this technique in early stroke phases and explore alternative, more effective doses for promoting swallowing recovery prior to its examination in any confirmatory trials. The investigators will use the study cohort to examine important subject specific parameters which influence response to the proposed intervention in dysphagic stroke patients. The overall aim of this study is to gather additional safety data on cumulative sessions of tDCS in acute-subacute phases of stroke, obtain information about effects of this intervention on important physiological and clinically relevant swallowing parameters, examine possible dose effects, and identify candidates who are more likely to benefit from this intervention. The experience gained from this project will guide planning of future confirmatory trials that use relevant clinical outcomes to assess potential benefits of this intervention and utilize important subject specific parameters to refine study inclusion criteria and aid in severity adjusted analysis.
Systemic midazolam prescribed perioperatively might have impact on pain, with studies suggesting antinociceptive and hyperalgesic effects. Anxiety might be a confounder in this association. In order to investigate the effect of midazolam on postoperative pain, a prospective cohort study will be conducted in four Portuguese ambulatory surgery units. A convenience sample with consecutive design will include patients admitted for open inguinal hernia repair. After anxiety and pain evaluation, a tailored dose of midazolam will be administered as premedication according to the anesthetist's best judgement within each unit's protocol (routine care; this dose may be null). Subsequent anesthesia and analgesia will be standardized. Postoperative pain will be blindly assessed by telephone interviews at 24h, 7 days, and 3 months. Statistical analysis will be performed separately for each gender, centre and type of anesthesia, adjusting for preoperative anxiety and other confounding variables with multivariate analysis.

The investigators intend to clarify the relation between anxiety, preoperative midazolam and postoperative pain.
In the procedures of regenerative endodontics therapy, K-files were intentionally used to violate the periapical tissues via overinstrumentation up to 2-3mm past the apical foramen to induce bleeding. Only the apex 1/3 of the root canal need to be filled with blood. PRF was injected into the root canal to a level below the CEJ, then wait for 10-15min to coagulate.
PURPOSE: A composition containing scallop components is provided to prevent and treat thrombus-associated diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating thrombus-associated diseases contains scallop components as an active ingredient. The scallop extract is isolated using water, acetone, dimethyl ether, low alcohol of 1-4 carbon atoms, or mixture solvent thereof. The scallop is Patinopecten yessoensis, Pecten albicans, Chlamys farreri, Chlamys swifti, Patinopecten(Mizuhopecten) tokyoensis, or Lima sowerbyi. A health food for preventing and treating thrombus-associated diseases contains scallop components as an active ingredient. The health food is manufactured in the form of powder, granule, tablet, capsule, syrup, or beverage.
The invention relates to an antibacterial chromophoric peptide, the amino acid sequence of which is as follows: Trp-Asp-Cys. The invention also discloses a preparation method of the antibacterial chromophoric peptide. The antibacterial chromophoric peptide can be prepared by taking marine shrimps as a raw material, carrying out enzymolysis on the marine shrimps by adopting protease, separating, purifying and freeze-drying the marine shrimps to obtain the antibacterial chromophoric peptide; the antibacterial chromophoric peptide can also be synthesized by adopting a peptide synthesis method or a synthesis and modification method; the synthesis or modification methods include, but are not limited to: biosynthesis, chemical synthesis, enzymatic synthesis, ligation, addition, coupling or derivatization. The invention also discloses an antibacterial application of the chromophoric peptide. The invention is a natural antibacterial agent, eliminates the side effects of residue, drug resistance and the like possibly caused by artificially synthesized antibacterial agents and antibiotics, can replace the traditional artificially synthesized antibacterial agents, has high antimicrobial activity and particularly has stronger inhibition capability on pathogenic bacteria of aquatic products. The method can improve the condition of low utilization rate of aquatic products in China, not only improves the utilization rate of aquatic resources, but also can remove the worry of consumers on the safety of the antibacterial agent in food.
INTRODUCTION: Arthroscopy is a well-established diagnostic modality for various orthopaedic conditions in veterinary medicine. The aim of this study was to describe the relationship of canine shoulder arthroscopy portals to major muscular, ligamentous, and neurovascular structures for anatomical and safety considerations.
MATERIALS AND METHODS: Arthroscopic exploration of 20 adult canine cadaver shoulders was performed. Each shoulder region was dissected layer by layer to the level of the joint. Musculotendinous, ligamentous, and cartilaginous lesions were documented. The distance was measured from each portal to neurovascular structures encountered.
RESULTS: Muscular lesions included the deltoideus, cleidobrachialis, omotransversarius, supraspinatus, infraspinatus, and teres minor muscles. The neurovascular structures identified were the omobrachial vein, the caudal circumflex humeral artery, axillobrachial vein, and branches of the axillary nerve. Lesions to the lateral glenohumeral ligament were noted from the caudal instrument portal and the middle arthroscope portal. Iatrogenic articular cartilage injuries were identified on the caudal humeral head and the glenoid.
CONCLUSION: This study supports the safety of lateral shoulder arthroscopy in dogs. Most local neurovascular structures are unaffected with traditional scope portal positions. Musculotendinous lesions are unavoidable due to the extensive muscling surrounding the shoulder but are unlikely to cause severe complications postoperatively.
Participants will complete a 6-week remote, technology-based physical activity intervention named ACTIVE-CR, in which they will be required to wear a wrist worn monitor to measure daily physical activity. Participants will be able to view their physical activity feedback on a web-based platform and will receive three online trainer sessions across the 6 weeks to help them to understand and interpret their data.
All participating subjects will serve as their own baseline control and will receive treatment of their androgenetic alopecia with LaseMD, a 1927nm Fractionated Thulium laser and post-treatment topically applied autologous platelet rich plasma at monthly intervals for a total of 4 treatment. The total duration of laser application, venipuncture, PRP preparation, and topical administration will take approximately 30 minutes. Post-treatment surveillance: The subject will be observed in the clinic under direct supervision of the treating physician for any post-treatment side-effects for up to 15 minutes.
Experimental: Intervention Group A novel Mindfulness-based Health Promotion program for Educators for active teachers will be employed. The intervention will be held once a week for 8-weeks, two-hour meetings (16.0-h total). Participants will be encouraged to meditate for 10-30 min/day via audio recording.
Major Depressive Disorder (MDD) is a prevalent mental health condition with a complex pathophysiology involving neuroinflammation, neurodegeneration, and disruptions in neuronal and glial cell function. Microglia, the innate immune cells of the central nervous system, release inflammatory cytokines in response to pathological changes associated with MDD. Damage-associated molecular patterns (DAMPs) act as alarms, triggering microglial activation and subsequent inflammatory cytokine release. This review examines the cellular mechanisms underlying MDD pathophysiology, focusing on the lipid-mediated modulation of neuroinflammation. We explore the intricate roles of microglia and astrocytes in propagating inflammatory cascades and discuss how these processes affect neuronal integrity at the cellular level. Central to our analysis are three key molecules: High Mobility Group Box 1 (HMGB1) and S100 Calcium Binding Protein β (S100β) as alarmins, and Neuron-Specific Enolase (NSE) as an indicator of neuronal stress. We present evidence from in vitro and ex vivo studies demonstrating how these molecules reflect and contribute to the neuroinflammatory milieu characteristic of MDD. The review then explores the potential of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) as neuroinflammation modulators, examining their effects on microglial activation, cytokine production, and neuronal resilience in cellular models of depression. We critically analyze experimental data on how ω-3 PUFA supplementation influences the expression and release of HMGB1, S100β, and NSE in neuronal and glial cultures. By integrating findings from lipidomic and cellular neurobiology, this review aims to elucidate the mechanisms by which ω-3 PUFAs may exert their antidepressant effects through modulation of neuroinflammatory markers. These insights contribute to our understanding of lipid-mediated neuroprotection in MDD and may inform the development of targeted, lipid-based therapies for both depression and neurodegenerative disorders.
Participants randomized to this arm will do muscle stretching and toning for 20-45 minutes, 3 times per week, for 6-12 weeks. This arm will also take the study drug 6R-BH4.
PURPOSE: Provided are cationic lipids for gene transfer and, more particularly, gene-transferring vectors consisting of a cholesterol compound dangling with an amino acid moiety such as lysine or ornithine. Also, provided is a method for preparing such cationic lipids. CONSTITUTION: Cationic lipids for gene transfer, which are capable of transferring nucleic acid materials into cells at very high efficiency with low cell toxicity, are represented by the following general formula. They are synthesized by forming a carbamate ester linkage between lysine or ornithine residue and a cholesteryl chloroformate in a solid-phase manner. This solid-phase synthesis method allows the automatic mass production of the vehicles suitable for use in gene therapy and transfer. In the formula, R is-CH2-CH2-CH2-CH2-NH3+ or-CH2-CH2-CH2-NH3+ and n is an integer of 1-10 with a proviso that the amino acid moiety is a homo-oligopeptide consisting of lysine or ornithine alone or a hetero-oligopeptide consisting of lysine and ornithine. Further, liposomes are made of the cationic lipids and very useful in transfecting nucleic materials into cells as well as in delivering pharmaceutically active materials into target cells.
The nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms foundin soil and water that rarely cause disease in humans. Since exposure to these organisms is universal and disease is rare, it can be concluded that normal host defenses are almost always sufficient to prevent infection. It follows that otherwise healthy individuals who develop disease must have abnormal susceptibility or immune defects that permit infection with nontubercuolous mycobacteria. The organisms that are most commonly encountered in clinical practice include Mycobacterium avium, and M. intracellulare \[collectively known as the M. avium complex (MAC)\], M. kansasii, M. fortuitum, M. abscessus, and M. chelonae. These organisms share significant structural and biochemical similarities with their more pathogenic relative, M. tuberculosis (MTB). Recognition of host factors that predispose or lead to NTM infection may have important implications for pathogenesis and therapeutic intervention, and may be applicable to the more virulent MTB. Identification of genetic or acquired susceptibility factors may lead to recognition of endogenous pathways that can be exploited therapeutically and to possible gene identification.

Over the last two decades, three important observations have been made regarding the pathogenesis of nontuberculous mycobacterial infections. 1) In patients infected with HIV, nontuberculous mycobacterial infections often occur when the CD4+ T-lymphocyte number falls below 50/mm3. This suggested that specific T cell products or activities were required for mycobacterial resistance. 2) An association was noted between pulmonary nontuberculous mycobacterial infections and a particular body habitus, predominantly in post-menopausal women (pectus excavatum, scoliosis, mitral valve prolapse). 3) Multiple defects have been found involving the interferon gamma synthesis and use pathways in patients with disseminated nontuberculous mycobacterial infection without HIV, suggesting this is a critical pathway for host defense against these organisms.

We seek to better characterize the predisposition to mycobacterial infection. This study will specifically address several aspects of immune function and investigate the proposed link to body morphotype in the relevant population. By collecting this information, we hope to provide insight into disease associations, infection susceptibility, and genetic predisposition to mycobacterial infection.
PURPOSE:To provide a skin cosmetic such as lotion, etc., containing specific amounts of levulinic acid and/or its salt, capable of promoting the turn-over rate of the corneal layer of the skin (rate of skin regeneration), and making a fair skin. CONSTITUTION:The objective skin cosmetic such as lotion, cream, milky lotion, pack, etc. contains levulinic acid and/or its salt, e.g. ammonium salt, alkali metal salt, alkaline earth metal salt, alkanolamine salt, etc. in an amount of 0.05-0.7wt%, preferably 0.1-0.5wt% based on the sum of the cosmetic components. The levulinic acid contained in the cosmetic is stable and absorbed in the skin with time to activate the skin cells, promote the function of the skin and accelerate the regeneration of the skin. By the combined effect with the other components in the cosmetic, it improves the healthy state of the skin, promotes the beautification, and remarkably improves the fineness, tenseness and gloss of the skin.