anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To provide a management system capable of simply confirming whether a document, such as a medical chart is correctly associated with various relevant apparatuses.SOLUTION: The management system manages, for example, a document, such as a medical chart of a patient in association with an apparatus, such as a container in medical relations. A document side ID area is defined on the document, and a document side ID, for example, a patient ID is applied. In addition, an apparatus arrangement area is defined in the document or other work places, and an operator arranges an apparatus within the apparatus arrangement area. An apparatus side ID, such as a patient ID is preliminarily applied to an apparatus. Photographing means, such as a camera photographs a document and an apparatus arrangement area as a photographic image. The document side ID and the apparatus side ID are respectively read from the photographic image, and whether the document side ID and the apparatus side ID are coincident is determined. Then, a photographed date by the photographing means, the photographic image, the document side ID, the apparatus side ID, and a coincidence determination result are associated with one another to be stored in a management database.
Disclosed are a facial mask with double-sided stereoscopic cross micropores, and a manufacturing method thereof. According to the present invention, the manufacturing method of a facial mask with double-sided stereoscopic cross micropores comprises: a step of spinning a natural silk yarn and a synthetic yarn in order to form a fabric having a double-sided stereoscopic cross microporous structure. The fabric includes both a synthetic fiber surface and a natural silk surface, or both a synthetic fiber surface and a mixed yarn surface made of a synthetic yarn and a natural silk yarn. The natural silk surface or the mixed yarn surface includes at least about 50% of natural silk for skin contact. All of the synthetic fiber surface, the natural silk surface, and the mixed yarn surface have a stereoscopic cross microporous structure for promoting the absorption of essence, increasing relative moisture retaining ability, and enhancing the overall elasticity and skin compatibility of the facial mask. In comparison with a common pure natural silk facial mask, the facial mask in the present invention has a synthetic fabric structure on one surface, and is thus further inexpensive. Furthermore, the facial mask in the present invention has excellent skin affinity, moisture retaining ability, skin compatibility, and elasticity, in comparison with a nonwoven fabric facial mask, a fabric facial mask, or a biological facial mask. Therefore, the facial mask in the present invention has various effective properties and can enhance industrial competitiveness.
PROBLEM TO BE SOLVED: To obtain an oxidizing dye capable of dyeing having excellent color fastness and hardly discoloring with the effect of the sunlight or postprocessing by combinedly containing a specific color developing component with a coupling component. SOLUTION: This oxidizing hair dye combinedly contains a mixture composed of 2-(2,5-diminophenyl)ethanol and 4-amino-2-aminomethyl-phenol as a color developing component with a coupling component (e.g. resorcinol or 5-amino-2- methylphenol). Each mixing amount of the components is 0.01-5wt.% of the color developing component, 0.01-3wt.% of the coupling agent and the total amount of both component contained in the hair dye is 0.02-8wt.%. Preferably, the hair dye is prepared to cream, a gel or an emulsion having pH6.8-11.5. As a dyeing treatment of the hair, the hair dye is mixed with an oxidizing agent just before the use and usually 60-200g of the hair dye is coated on the hair.
PURPOSE:A pharmaceutical member composition, consisting essentially of a water-swellable urethane resin and a drug having physiological activity, and having improved shape retaining property and dry touh after absorbing a solution to be absorbed and good drug release ability. CONSTITUTION:A pharmaceutical member composition consisting essentially of a water-swellable urethane resin such as a resin, obtained from a polyisocyanate, e.g. isophorone diisocyanate or toluene diisocyanate, and polyol consisting of polyether polyol, and having substantially no NCO, and a drug having physiological activity. An adduct of a compound having at least two active hydrogen atoms, e.g. low-molecular polyol, polyhydric phenol and amine compound with ethylene oxide (EO) and if necessary another alkylene oxide may be cited as the above-mentioned polyol. Preferably, the EO content is >=40%, particularly 60-85% and equivalent is 100-5,000, preferably 500-4,000.
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Here, a macrophage infection model was used to unravel the role of the histone deacetylase sirtuin 6 (SIRT6) in Mtb-triggered regulation of the innate immune response. Mtb infection downregulated microRNA-26a and upregulated its target SIRT6. SIRT6 suppressed glycolysis and expression of HIF-1α-dependent glycolytic genes during infection. In addition, SIRT6 regulated the levels of intracellular succinate which controls stabilization of HIF-1α, as well as the release of interleukin (IL)-1β. Furthermore, SIRT6 inhibited inducible nitric oxide synthase (iNOS) and proinflammatory IL-6 but augmented anti-inflammatory arginase expression. The miR-26a/SIRT6/HIF-1α axis therefore regulates glycolysis and macrophage immune responses during Mtb infection. Our findings link SIRT6 to rewiring of macrophage signaling pathways facilitating dampening of the antibacterial immune response.
Either of two standard, long acting anti-cholinergic medications (Long acting Tolterodine or Extended Release Oxybutynin)will be given. Subjects receive 8 weeks of medication counseling in conjunction with the medications. Medications will be continued for 1 year.
Objectives: To introduce a novel hydrodynamic design for a flexible ureteroscope that can increase stone debris clearance. Methods: Based on hydrodynamics, the new design allowed the ureteroscope to have six water jets. Fluid gushed from the six jets and would ultimately converge into an eddy. The safety and stone debris clearance efficiency were tested in a 3D-printed kidney model. Stone fragments between 0.5 and 1 mm were used to mimic the debris. A ureteroscope already approved for marketing was used as a control. Results: The new design did not change the local renal pressure and did not raise the whole renal pressure under irrigation at 80 or 100 mL/min but slightly raised it under irrigation at 120 mL/min. The pressures in the 2 g stone clearance procedures were 26.0, 33.1, and 37.5 cmH2O for the new design and 25.1, 30.2, and 39.3 cmH2O for the current design; in the 4 g stone clearance procedures, the pressures were 30.1, 37.2, and 40.0 cmH2O for the new design and 26.9, 30.8, and 39.8 cmH2O for the current design, all under conditions of 80, 100, and 120 mL/min irrigation, respectively. The new design significantly improved the stone clearance rate by ∼10-fold. It effectively cleared 2 and 4 g stones within 900 seconds under the three irrigation rates. In contrast, the current design cleared <10% of the stone debris in all tests. Conclusion: The new hydrodynamic design significantly improved the stone debris clearance rate without causing obviously increased renal pressure, and the improvement was maintained under different irrigation pressures and stone burdens.
BACKGROUND AND AIMS: Long noncoding RNAs are involved in the pathogenesis of atherosclerosis. As long noncoding RNAs maternally expressed gene 3 (Meg3) prevents cellular senescence of hepatic vascular endothelium and obesity-induced insulin resistance, we decided to examine its role in cellular senescence and atherosclerosis.
METHODS AND RESULTS: By analyzing our data and human and mouse data from the Gene Expression Omnibus database, we found that Meg3 expression was reduced in humans and mice with cardiovascular disease, indicating its potential role in atherosclerosis. In Ldlr-/- mice fed a Western diet for 12 weeks, Meg3 silencing by chemically modified antisense oligonucleotides attenuated the formation of atherosclerotic lesions by 34.9% and 20.1% in male and female mice, respectively, revealed by en-face Oil Red O staining, which did not correlate with changes in plasma lipid profiles. Real-time quantitative PCR analysis of cellular senescence markers p21 and p16 revealed that Meg3 deficiency aggravates hepatic cellular senescence but not cellular senescence at aortic roots. Human Meg3 transgenic mice were generated to examine the role of Meg3 gain-of-function in the development of atherosclerosis induced by PCSK9 overexpression. Meg3 overexpression promotes atherosclerotic lesion formation by 29.2% in Meg3 knock-in mice independent of its effects on lipid profiles. Meg3 overexpression inhibits hepatic cellular senescence, while it promotes aortic cellular senescence likely by impairing mitochondrial function and delaying cell cycle progression.
CONCLUSIONS: Our data demonstrate that Meg3 promotes the formation of atherosclerotic lesions independent of its effects on plasma lipid profiles. In addition, Meg3 regulates cellular senescence in a tissue-specific manner during atherosclerosis. Thus, we demonstrated that Meg3 has multifaceted roles in cellular senescence and atherosclerosis.
Patients receive a 90 minute continuous infusion of irinotecan on days 1, 8, 15, and 22 for 4 weeks, followed by a 2 week rest period. Courses of treatment are repeated every 42 days. Patients continue treatment in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 1 year, then every 6 months for the next 4 years.
In the management of brachial plexus birth palsies, the quality of the roots eligible for reconstruction is thought to be a key issue. The aim of the present study was to evaluate the correlations between pathological root examination and motor recovery after brachial plexus reconstructions. Quantitative histopathological analysis of intraneural fibrosis was conducted on 72 nerve transections (40 roots, 18 trunks and 14 suprascapular nerves) in 20 patients. Clinical recovery of targeted muscles after surgery was assessed by standardized functional scores. After a mean follow-up of 32 months, patients with a lower fibrosis rate for the suprascapular nerve had greater global Mallet scores (r = -0.57; p = 0.042) as well as a greater active shoulder flexion (r = -0.66; p = 0.015). Correlations were also found between C6 root and upper trunk fibrosis rate and some of the subsections of the Mallet score, active movement scale for the biceps and active elbow flexion. These results seem to confirm the relevance of intraoperative pathological evaluation of the roots and nerves after neuroma resection to optimally define the reconstruction strategy.Level of evidence: IV.
It is currently unknown whether changes in systemic venous congestion, assessed by venous excess ultrasound score (VExUS), are associated with worsening renal function, reduced diuretic and natriuretic response, and poor prognosis in patients with acute decompensation of heart failure (AHF).

This prospective, observational, single-center study included patients admitted to the intensive care unit with AHF. At admission all patients undergo bedside Doppler ultrasound of inferior vena cava, hepatic, portal and renal veins to determine blood flow patterns. Congestion was graded with the VExUS score (grade 0, grade 1, grade 2, grade 3). Sodium concentration in a spot urine sample was assessed in 1 hour after first standard intravenous loop diuretic administration. The primary endpoint was the development of acute kidney injury (AKI), defined as oligoanuria (diuresis rate \<0.5 ml/kg/hour for 6 hours) and an increase of serum creatinine \>26 µmol/l within a 48-hour period or 50% from baseline creatinine within a week. The secondary endpoints were in-hospital mortality, change in spot urine sodium content \<50 mmol/l and development of diuretics resistance (defined as the need to double starting dose of intravenous furosemide in 6 hours without adding a different class of diuretic agents).
The extent of percutaneous absorption of topical corticosteroids, including clobetasol propionate, is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings (see DOSAGE AND ADMINISTRATION). 

As with all topical corticosteroids, clobetasol propionate can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids (see DOSAGE AND ADMINISTRATION). 

Once absorbed through the skin, topical corticosteroids enter pharmacokinetic pathways similarly to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids, including clobetasol propionate and its metabolites, are also excreted into the bile. 

Following repeated nonocclusive application in the treatment of scalp psoriasis, there is some evidence that clobetasol propionate topical solution has the potential to depress plasma cortisol levels in some patients. However, hypothalamic-pituitary-adrenal (HPA) axis effects produced by systemically absorbed clobetasol propionate have been shown to be transient and reversible upon completion of a 2-week course of treatment.
The invention provides Shuanghuanglian mouthwash and a preparation method thereof. The Shuanghuanglian mouthwash is prepared from 1-50g of honeysuckle flower (lonicera confusa), 0.1-15g of weeping forsythia, 0.1-15g of baical skullcap root, 0.01-1g of menthol crystal, 30-90ml of glycerol, 1-50g of xylitol, 1-20ml of ethanol, 0.05-0.5g of potassium sorbate and 0.01-10ml of essence in proportion by weight. The Shuanghuanglian mouthwash is prepared by taking the honeysuckle flower (lonicera confusa), the baical skullcap root and the weeping forsythia as main raw materials and adding other raw and auxiliary materials, wherein the baical skullcap root, the honeysuckle flower (lonicera confusa) and the weeping forsythia are respectively extracted and concentrated to obtain the extracts. For the Shuanghuanglian mouthwash and the preparation method thereof, a Shuanghuanglian classic formula of the Chinese medicine is applied, and particularly, an extraction process is optimized on the basis of the Shuanghuanglianclassic formula of the Chinese medicine, wherein the PH value of an alcoholic solution is regulated in a process for extracting the honeysuckle flower (lonicera confusa) extract and the weeping forsythia extract with the method provided by the invention; thus, the obtained Shuanghuanglian mouthwash has the advantages of high yield, fewer impurities, good taste and clear solution, has a good effect of keeping oral health and can effectively kill oral pathogenic bacteria and various harmful bacteria and viruses, including coronavirus and avian influenza virus. Compared with common gargles made of pure Chinese medicines or western medicines in the market, the Shuanghuanglian mouthwash provided by the invention is convenient to prepare and difficult to precipitate after long-term storage, has the advantages of good stability, safety and effectiveness and is an ideal preparation for daily oral care. The preparation method is applicable to industrial production.
PURPOSE: We evaluated the efficacy of megestrol in improving chemotherapy-related anorexia by analyzing the related scales of taste alteration.
METHODS: We conducted the current study on a group of advanced patients with cancer with two or more chemotherapy cycles. The chemotherapy-induced taste alteration scale (CiTAs) scale helped assess the megestrol effects on basic taste perception, aversive taste changes, unpleasant symptoms, and associated concerns. Furthermore, the Short Nutritional Assessment Questionnaire scale (SNAQ) helped measure the impact of megestrol on malnutrition likelihood in patients experiencing chemotherapy-induced anorexia. The World Health Organization Quality of Life (WHOQOL)-BREF Scale was used to evaluate the quality of life of participants, producing scores related to physical health, psychological well-being, environmental factors, and social relationships.
RESULTS: The CiTAs scale assessment indicated that administering megestrol significantly enhanced taste perception among advanced patients with cancer undergoing chemotherapy. Notably, the megestrol group patients showed significantly higher Short Nutritional Assessment Questionnaire (SNAQ) scores than the control group. The megestrol group patients also exhibited higher physiological (PHYS) scores than their control group counterparts. However, this distinction was not statistically significant. The study findings indicate that patients who received megestrol demonstrated significantly higher scores in psychological (PSYCH) and environmental(ENVIR) domains than the control group. Furthermore, megestrol administration was associated with significantly elevated SOCIL and ENVIR levels in patients.
CONCLUSION: The proficient efficacy evaluation of megestrol in enhancing appetite, mitigating malnutrition likelihood, and improving the quality of life of chemotherapy-induced anorexic patients can be achieved through taste-related scales.
BACKGROUND: Mesoamerican nephropathy is a leading contributor to premature mortality in Central America. Efforts to identify the cause are hampered by difficulties in distinguishing associations with potential initiating factors from common exposures thought to exacerbate the progression of all forms of established chronic kidney disease (CKD). We explored evidence of disease onset or departure from the healthy estimated glomerular filtration rate distribution [departure from ∼eGFR(healthy)] in an at-risk population.
METHODS: Two community-based cohorts (adults aged 18-30 years, n = 351 and 420) from 11 rural communities in Northwest Nicaragua were followed up over 7 and 3 years respectively. We examined associations with both (i) incident CKD and (ii) the time point of departure from ∼eGFR(healthy), using a hidden Markov model.
RESULTS: CKD occurred in men only (male incidence rate: 0.7%/year). Fifty-three (out of 1878 visits, 2.7%) and 8 (out of 1067 visits, 0.8%) episodes of probable departure from ∼eGFR(healthy) occurred in men and women, respectively. Cumulative time in sugarcane work and symptoms of excess occupational sun exposure were associated with incident CKD. The same exposures were associated with probability of departure from ∼eGFR(healthy) in time-updated analyses along with measured and self-reported weight loss, nausea, vomiting and cramps, as well as non-steroidal anti-inflammatory drug use.
CONCLUSIONS: CKD burden in this population is high and risk factors for established disease are occupational. Additionally, a syndrome suggesting an alternative exposure is associated with evidence of disease onset supporting a possible separate unknown initiating factor for which further investigation is needed. Interventions to reduce the impact of occupational risks should be pursued meanwhile.
The present discloses systems and methods for tissue analysis, biopsy, and treatment utilizing at least exogenous fluorophores and near infrared light. A method is disclosed for optically determining the presence of abnormal cells, such as cancer, in tissue. The method includes applying one or more exogenous fluorophores into tissue in an animal body, wherein the exogenous fluorophores include a targeting moiety formulated to bond with a selected site on abnormal cells. The method includes illuminating the one or more exogenous fluorophores in the tissue with near infrared light from an elongated optical probe to generate fluorescent light from exogenous fluorophores present in the tissue. The method includes receiving fluorescent light generated from the one or more exogenous fluorophores in the tissue. The method includes determining if abnormal cells are present in the tissue based on the fluorescent light generated from the one or more exogenous fluorophores in the tissue.
Patients undergo collection of blood samples at 4-6 weeks prior to surgery/ablation and at 12 weeks, 6, 12, 18 and 24 months after surgery/ablation. Patients' previously collected tissue samples are analyzed. Patients' medical records are also reviewed at baseline, 4-6 weeks prior to surgery/ablation, 12 weeks, 6, 12, 18 and 24 months after surgery/ablation, and then every 6 months for 3 years.
Influenza A viruses are widely found in nature and can infect a wide variety of birds and mammals, including humans. Some types of influenza A viruses are more likely to spread from animals to humans, and researchers are interested in monitoring these viruses and developing potential vaccines for them. H7N7 is one type of influenza A virus. In recent years, there have been several H7N7 outbreaks among humans, and the development of an H7N7 vaccine is a high priority. This study will enroll two groups of participants: people who have previously received one of three types of a pandemic LAIV as part of a research study and people who have not previously received a LAIV vaccine. The purpose of this study is to evaluate the safety and immunogenicity of a single dose of an inactivated H7N7 vaccine in these two groups of participants.

At a baseline study visit, all participants will undergo a medical history review, physical examination, vital sign measurements, blood collection, and nasal secretion collection. Female participants will provide a urine sample for pregnancy testing. All participants will then receive one intramuscular (IM) injection of the H7N7 study vaccine in their upper arm. They will remain in the clinic for 30 minutes for observation and monitoring. Participants will monitor and record any adverse symptoms between study visits. Additional study visits will occur at Days 4, 7, 14, 28, 56, and 180. At select study visits, participants will undergo a medical history review, physical examination, and nasal secretion collection. Blood collection will occur at each visit; some blood samples may be stored for future research.
The data processing system comprises a mask analysis module and a first prompt module. The mask analysis module can generate reference data according to a tumor position mask and an organ position mask of the medical image. The reference data includes reference tumor location, reference tumor size, invasive organ name, and SUV value. The first prompt module can generate first prompt contents according to the reference data and the tumor category labels, receive first prompt information, and input an initial report, the first prompt contents and the first prompt information into the large language model. The initial tumor category, initial tumor location, and initial tumor size are recorded in the initial report. The large language model is capable of generating an optimized report from the initial report, the first prompt and the first prompt. The optimization report includes optimizing tumor class, optimizing tumor location, optimizing tumor size, invasive organ name, and SUV value. The data processing system is capable of improving the accuracy of the generated report. A data processing method is also provided.
Patients receive placebo PO BID for 3-6 weeks prior to SOC RP. Patients also undergo biopsy at time of surgery and collection of blood samples during screening and on study.