anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Research on a health-related event at the stage of labour and the occurrence of adverse outcomes at the school age has provided inconclusive results. Thus far, no systematic reviews have been conducted. Thus, the objective of this study is to investigate the association between hypoxia during pregnancy or delivery and the subsequent occurrence of a developmental dyslexia in school-age children.
METHODS: We used a standard search strategy of electronic databases (PubMed, PsycINFO, Web of Science, EMBASE, and Cochrane Library) and handsearching. We included observational studies (cohort studies, case-control studies) that consider as an exposure the presence of hypoxia during pregnancy or delivery, and as an outcome, developmental dyslexia in school-age children. Two reviewers independently conducted the search and determined eligibility, which was not restricted by language or year of publication.
RESULTS: The search took place until 1 April 2023. Of the 1,336 abstracts screened, 6 were assessed for eligibility. Of the six eligible studies, no studies met the pre-specified eligibly criteria.
CONCLUSIONS: We were unable to assess the association between hypoxia and developmental dyslexia, as no eligible studies were found. Thus, the association between hypoxia during pregnancy or delivery and dyslexia in school-age children remains unknown.
Background: Overall survival rate for out-of-hospital cardiac arrest rarely exceeds 5%. While bystander cardiopulmonary resuscitation (CPR) can increase survival for cardiac arrest victims up to four times, bystander CPR rates remain low in Canada (15%). Survivors have a quality of life similar to the general population. Most cardiac arrest victims are men in their sixties; they usually collapse in their own home (85%), where bystander CPR rates are even lower. The event is witnessed by a family member or bystander 50% of the time. These statistics appear to support a strategy of targeted CPR training for an older population that is most likely to witness a cardiac arrest event. Interest in CPR training appears to decrease with advancing age. Behaviour surrounding CPR training and performance has never been studied using the theoretical constructs of a well validated behavioural theory (the Theory of Planned Behaviour).

Objectives: The overall goal of this study is to conduct a survey to better understand the behavioural factors associated with successful CPR knowledge transfer in an independent-living older population (aged 55 or more). Specific objectives are: 1) To conduct semi-structured qualitative interviews to identify factors influencing CPR training and performance behaviours; 2) To then develop a survey instrument about factors influencing CPR training and performance behaviours based on a systematic review of the literature, the results of the semi-structured interviews, and theoretical constructs; and 3) To conduct a telephone survey among an independent-living population aged 55 or more using the survey instrument, and to identify factors and strategies that might be targeted by KT interventions.

Methods: Objective 1: We will tape-record semi-structured qualitative interviews conducted among 20 randomly selected participants aged 55 or older, and perform inductive analyses to identify categories and themes. Objective 2: The survey instrument will be developed based on a completed systematic review of the literature, and results from objective 1. The two behaviours under study will be �seeking CPR training and providing CPR to a cardiac arrest victim�. Objective 3: We will develop and conduct a nation-wide telephone survey using random digit dialling. The telephone survey will be centrally administered and stratified by province and large or small communities in order to obtain a representative random sample of the Canadian population. The study population will include all men and women aged 55 or older, living independently in the community, with the ability to communicate in English or French. We will seek to obtain a participation rate of 60% or greater. We estimate requiring approximately 500 respondents to identify factors and strategies for improving CPR KT in our target population. Analyses will include measures of sampling bias, reliability of the measures, construct validity, as well as multiple regression analyses to identify constructs and beliefs most salient to seniors� decisions about whether to attend CPR classes or perform CPR.
BACKGROUND: Cancer has surpassed infectious diseases and heart ailments, taking the top spot in the disease hierarchy. Cervical cancer is a significant concern for women due to high incidence and mortality rates, linked to the human papillomavirus (HPV). HPV infection leads to precancerous lesions progressing to cervical cancer. The cervix's external os, near the vagina, hosts various microorganisms. Evidence points to the link between vaginal microbiota and HPV-induced cervical cancer. Cervical cancer onset aligns with an imbalanced Th1/Th2 immune response, but the role of vaginal microbiota in modulating this imbalance is unclear.
METHODS: In this study, we collected vaginal samples from 99 HPV-infected patients across varying degrees of lesions, alongside control groups. These samples underwent bacterial DNA sequencing. Additionally, we employed Elisa kits to quantify the protein expression levels of Th1/Th2 cytokines IL2, IL12, IL5, IL13, and TNFa within the centrifuged supernatant of vaginal-cervical secretions from diverse research subjects. Subsequently, correlation analyses were conducted between inflammatory factors and vaginal microbiota.
RESULTS: Our findings highlighted a correlation between decreased Lactobacillus and increased Gardenerella presence with HPV-induced cervical cancer. Functionally, our predictive analysis revealed the predominant enrichment of the ABC transporter within the vaginal microbiota of cervical cancer patients. Notably, these microbiota alterations exhibited correlations with the production of Th1/Th2 cytokines, which are intimately tied to tumor immunity.
CONCLUSIONS: This study suggests the potential involvement of vaginal microbiota in the progression of HPV-induced cervical cancer through Th1/Th2 cytokine regulation. This novel insight offers a fresh perspective for early cervical cancer diagnosis and future prevention strategies.
OBJECTIVE: The modified Harborview Risk Score (HRS) is a simple measure initially derived from a single institutional dataset used to predict ruptured abdominal aortic aneurysm (rAAA) repair survival preoperatively using basic labs and vital signs collected upon presentation. However, validation of this widely applicable scoring system has not been performed. This study aims to validate this scoring system using a large multi-institutional database.
METHODS: All patients who underwent repair of an rAAA from 2011 to 2018 in the National Surgical Quality Improvement Program (NSQIP) and at a single academic medical center were included. The modified HRS was calculated by assigning 1 point for each of the following: age >76 years, creatinine >2 mg/dL, international normalized ratio >1.8, and any systolic blood pressure less than 70 mmHg. Assessment of the prediction model was then completed. Using a primary outcome measure of 30-day mortality, the receiver operating characteristic area under the curve was calculated. The discrimination between datasets was compared using a Delong test. Mortality rates for each score were compared between datasets using the Pearson χ2 test. Comparative analysis for patients with a score of 4 was limited due to a small sample size.
RESULTS: A total of 1536 patients were identified using NSQIP, and 163 patients were assessed in the institutional dataset. There were 518 patients with a score of 0 (455 NSQIP, 63 institutional), 676 patients with a score of 1 (617 NSQIP, 59 institutional), 391 patients with a score of 2 (364 NSQIP, 27 institutional), 106 with a score of 3 (93 NSQIP, 13 institutional), and 8 patients with a score of 4 (7 NSQIP, 1 institutional). No difference was found in the receiver operating characteristic area under the curves between datasets (P = .78). Thirty-day mortality was 10% NSQIP vs 22% institutional for a score of 0; 28% NSQIP vs 36% institutional for a score of 1; 41% NSQIP vs 44% institutional for a score of 2; 45% NSQIP vs 69% institutional for a score of 3; and 57% NSQIP vs 100% institutional for a score of 4. Score 0 was the only score with a significant mortality rate difference between datasets (P = .01).
CONCLUSIONS: The modified HRS is confirmed to be broadly applicable as a clinical decision-making tool for patients presenting with rAAAs. Therefore, this easily applicable model should be applied for all patients presenting with rAAAs to assist with provider and patient decision-making prior to proceeding with repair.
Two probiotic capsules (BIO-K+ CL-1285®) per day. Patients took their daily dose 2h after breakfast and antibiotic administration each day. Patients were then followed for an additionnal 21 days after completion of the assigned intervention.
Piscine red blood cells (RBC) are nucleated and have been characterized as mediators of immune responses in addition to their role in gas exchange. Salmonid RBC are major target cells of Piscine orthoreovirus-1 (PRV-1), the etiological agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). PRV-1 replicates in RBC ex vivo, but no viral amplification has been possible in available A. salmon cell lines. To compare RBC basal transcripts and transcriptional responses to PRV-1 in the early phase of infection with non-susceptible cells, we exposed A. salmon RBC, Atlantic salmon kidney cells (ASK) and Salmon head kidney cells (SHK-1) to PRV-1 for 24 h. The RNA-seq analysis of RBC supported their previous characterization as pluripotent cells, as they expressed a wide repertoire of genes encoding pattern recognition receptors (PRRs), cytokine receptors, and genes implicated in antiviral activities. The comparison of RBC to ASK and SHK-1 revealed immune cell features exclusively expressed in RBC, such as genes involved in chemotactic activity in response to inflammation. Differential expression analysis of RBC exposed to PRV-1 showed 46 significantly induced genes (≥ 2-fold upregulation) linked to the antiviral response pathway, including RNA-specific PRRs and interferon (IFN) response factors. In SHK-1, PRV induced a more potent or faster antiviral response (213 genes induced). ASK cells showed a differential response pattern (12 genes induced, 18 suppressed) less characterized by the dsRNA-induced antiviral pathway. Despite these differences, the RIG-I-like receptor 3 (RLR3) in the family of cytosolic dsRNA receptors was significantly induced in all PRV-1 exposed cells. IFN regulatory factor 1 (IRF1) was significantly induced in RBC only, in contrast to IRF3/IRF7 induced in SHK-1. Differences in IRF expression and activity may potentially affect viral propagation.
335,202. Groves, W. W., (I. G. Farbenindustrie Akt.-Ges.). June 10, 1929. Medicines for internal use.-Heart-stimulating substances are extracted from muscular tissue by extraction with water-soluble organic solvents, lipoids being removed by treating the tissue before extraction, or by treating the extract obtained, with a water-insoluble solvent. The aqueous extract remaining after expelling the water-soluble solvent is saponified with caustic soda, barium hydroxide or the like to destroy substances affecting the intestine or uterus and, after the saponifying agent has been removed, and if desired after removal of byproducts of saponification by further treatment with a water insoluble organic, solvent, may be sterilized by heating or mixed with a preservative. In an alternative process the aqueous extract after saponification is evaporated to dryness and freed from ballast substances by extraction with methyl alcohol of high strength. Dried muscles mav be employed, but in this case water is added before or during extraction with the water-soluble solvent. The tissues may be treated at the natural hydrogen-ion concentration or after addition of alkali. The active substances are soluble in water-soluble organic solvents containing at least 10 per cent of water, but not in highly concentrated solvents. Soluble solvents specified are methyl and ethyl alcohols and acetone; insoluble solvents are ether and methylene chloride. Specificatsons 279,445, 306,606, and 306,608 are referred to.
In the prevention and treatment of cervical region pathologies, various exercise methods are applied in the clinic. The clinical exercises vary according to the time and severity of the pathology but also according to the pathology itself. These exercises include exercises focusing on flexor or extensor muscles. The aim of this study was to investigate the morphological changes in the neck muscles of cervical spinal stabilization exercises focused on flexor and extensor muscles applied to healthy individuals. At least 27 healthy male subjects between the age of 18-30 are planned to be included in the study. Individuals will be divided into 3 groups by simple randomization method. In one group cervical stabilization exercise program focused on the flexor muscles will be applied and the other group cervical stabilization exercise program focused on the extensor muscles will be applied for 8 weeks. Individuals in the control group will only be evaluated without exercise. In the study, by using magnetic resonance imaging (MRI) method as the main evaluation, muscle anatomical cross-sectional area and T2 relaxation time measurements will be made and morphological changes in muscles will be determined. These evaluation procedures will be performed on longus colli, sternocleidomastoid, semispinalis cervicis, multifidus and upper trapezius muscles. As additional evaluation methods, muscle strength and muscle endurance tests, normal joint motion measurements, posture evaluation and MRI measurement of cervical spine curvature will be performed. All evaluations will be performed at the beginning and at the end of these 8 weeks and the effects of the exercises applied on the muscles in the two groups will be examined.
Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.
The study isolated two strains of intestinal autochthonous bacteria Lactiplantibacillus plantarum1 (MH155966.1) (L1) and Lactiplantibacillus plantarum2 (MH105076.1) (L2) from the Choobdeh Abadan region. The aim of this study was to investigate the effects of different strains of probiotic bacteria on the growth performance, digestive enzyme activity, histopathologic and histomorphometric characterization of the intestine, expression of immune and growth related genes, and evaluate Lates calcarifer resistance against Vibrio alginolyticus. To achieve this, for each treatment 60 L. calcarifer juveniles (75 ± 12 g) were randomly distributed in three fiberglass tanks (300 L) and fed for 45 days. The treatments were established as Diet 1 (control diet); L1 (diet with Lb. plantarum isolated 1); L2 (diet with Lb. plantarum isolated 2) with a bacterial concentration of 1 × 109 CFU/g. Nine fish from each treatment were sampled and examined, after euthanasia. The fish were placed 2 cm from the beginning of the intestine for microscopic sampling of villi height, villi width and thickness of the epithelium, with 3 treatments: The result showed differences in the mean values of total weight were found at the end of the experiment. After 45 days of culture, the fish fed with L1 had higher (P < 0.05) growth performance than the other treatment groups. But at the end of the trial, in L2, the digestive enzyme activities were higher (P < 0.05) than the other treatment groups. The fishes fed diets supplemented with the L2 group, like the digestive enzyme activities test, presented an increase in the thickness of the epithelium of the intestine, and villus height, and villus width were greatest in L2. Fish feeding with L1 and L2 probiotics induced higher transcription levels of interleukin-10 (IL-10), granulocyte-macrophage colony-forming cells (GMCFC), epidermal growth factor (EGF), and Transforming Growth Factor Beta (TGF-β) genes in the gut, which may correlate with better immune and hematological parameters in these groups. The results of the challenge test revealed that the percentage of survival was significantly higher in L1 (76.2%) and L2 (80.95%) treatments than in the control (P < 0.05). These results indicate that host-derived probiotics (Lb. plantarum) have significant potential as important probiotics to enhance nutrient utilization, Digestive enzymes, and metabolism by increasing the gut surface area of Lates calcarifer juveniles at 45 days of culture.
A suite of fluidless predictive machine learning models includes a fluidless mortality module, smoking propensity model, and prescription fills model. The fluidless machine learning models are trained against a corpus of historical underwriting applications of a sponsoring enterprise, including clinical data of historical applicants. A data appended procedure supplements historical applications data with public records and credit risks. Various features of this data are engineered for improved predictive characteristics. Fluidless models are trained by application of a random forest ensemble including survival, regression and classification models. The trained models produce high-resolution, individual mortality scores. A fluidless underwriting protocol runs these predictive models to assess mortality risk and other risk attributes of a fluidless application that excludes clinical data to determine whether to present an accelerated underwriting offer. If any of the fluidless predictive models determines a high risk target, the applicant is required to submit clinical data.
The study plans to enroll 32 subjects. After signing the informed consent form and meeting the inclusion and exclusion criteria, patients will receive standard-dose treatment of the RC48, Adebrelimab, Apatinib and S-1 regimen for 3-4 cycles (every 3 weeks) before surgery. Apatinib will only be used for 14 days in the last cycle. Imaging studies will be conducted 3-4 weeks after the last dose to assess the efficacy of neoadjuvant therapy and the possibility of radical D2 gastrectomy. The treatment plan after curative surgery for gastric cancer will be determined by the investigators and the patients based on the pathological findings. Patients who benefit clinically after surgery may receive adjuvant therapy with RC48, Adebrelimab, Apatinib and S-1 for 4 cycles (the first treatment is expected to start around 4 weeks after surgery) or follow the standard postoperative adjuvant regimen recommended by the guidelines.
NEW MATERIAL:The serum calcium lowering substance PX [molecular weight, 20,000-30,000 (gel-filtration analysis with Sephadex); isoelectric point, 3-5pH; having sensitivity to trypsin; physiological activity, at least having the activity to lower the serum calcium level and keeping the activity even by heating at 80 deg.C for 5min]. USE:It has activities to lower the serum calcium level and decrease the peripheral leucocyte, and useful as a remedy for bulbospinal paralysis, muscular dystrophy, etc. PREPARATION:The acetone-dried powder of swine pancreas is suspended in a buffer solution, and extracted by stirring under cooling. The extract liquid is centrifuged, and the supernatant liquid is added with an organic solvent and centrifuged. The recovered supernatant liquid is added with an organic solvent, and the precipitate is recovered by centrifugal separation. The precipitate is dissolved in a buffer solution, fractionated by gel-filtration, again fractionated with ion exchange material, eluted by increasing the salt concentration of the buffer solution, and the obtained active fraction is dialyzed with water to obtain the objective serum calcium lowering substance PX.
The invention comprises substituted imidazolones of the general formula <FORM:0757650/IV(a)/1> wherein n is 2 or 3, and their acid addition and quaternary salts, and the preparation thereof by condensing a carboxylic acid of the general formula <FORM:0757650/IV(a)/2> wherein n has the above significance or a lower alkyl ester or nitrile thereof, with ethylenediamine or an acid addition salt thereof.  Suitable esters are the methyl, ethyl, propyl, isopropyl, butyl, pentyl and hexyl esters.  The reaction is preferably carried out by heating, e.g. the nitrile may be heated with the p-toluenesulphonic acid salt of ethylene diamine.  The acid addition salts are prepared by contacting the free imidazolines with an acid to form, for example, the tartrate, citrate, phthalate, lactate, formate, phosphate, nitrate, sulphate, hydrochloride, hydrobromide, hydroiodide and acetate salts, and the quaternary salts are formed by reaction with an ester, e.g. an alkyl halide or sulphate such as dimethylsulphate, methyl iodide, ethyl bromide and propyl chloride.  In the examples, 2-(1,2,3,4-tetrahydro - 1 - naphthyl) - imidazoline and its hydrochloride, dehydrogen phosphate, hydrobromide, cyclohexylsulphamate, bitartrate and saccharinate salts and the hydrochloride salt of 2-(1-indanyl)-imidazoline are prepared. Intermediate compounds.  1,2,3,4-Tetrahydro-1-naphthonitrile is prepared by heating the corresponding 1-naphthoamide with thionyl chloride.  Lower alkyl esters of 1,2,3,4-tetrahydro-1-naphthoic acid and 1-indone-carboxylic acid are prepared by heating the free acids with alcohols, e.g. methyl alcohol.
PURPOSE: To obtain a new phosphoric acid derivative, capable of specifically inhibiting actions of a metallic protease, an angiotensin-converting enzyme, an endothelin-converting enzyme and an enkephalinase and useful as an analgesic, a stegnotic agent or a therapeutic agent, etc., for cardiac insufficiency or hypertension. CONSTITUTION: This compound of formula I (R1 to R3 are each H, a lower alkyl, hydroxy, a lower alkoxy, a halogen, nitro, amino, etc.; R4 is H, a lower alkyl or a lower aralkyl; R5 is a lower alkyl or a lower aralkyl; R6 is hydroxy, a lower alkyl or a lower aralkyl), e.g. benzyl 2-[N-ethyl- N-(diethoxyphosphorylmethyl)-carbamoyl]-1,2,3,4-tetrahydroisoquinoline-3- carboxylate. Furthermore, the compound of formula I is obtained by de- esterifying a compound of formula III obtained by using a compound of formula II as a starting raw material. The compound of formula III is new.