anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Testosterone esters for use in pharmaceutical hormone preparations (see Group VI) may be produced by conventional methods.  For example, testosterone undecylenate is prepared by reacting testosterone with undecylenyl chloride in anhydrous benzene in the presence of anhydrous pyridine.  Other esters specified are the valerate and propionate.ALSO:A mixture of testosterone undecylenate, testosterone valerate and testosterone propionate is used in hormone preparations such as solutions (especially oil solutions) for parenteral administration, suspensions, emulsions, implantates, tablets, dragees, salves and creams.  Specified carrier materials include vegetable oils, benzyl alcohol, polyethylene glycols, gelatine, lactose, starch, magnesium stearate, talc, petroleum jelly and cholesterol.  Additional additives include preserving, stabilizing, wetting or emulsifying agents, buffer substances, local anaesthetics and substances having an effect on the blood vessels.  Examples are given of a preparation in sesame oil, a preparation in crystal form and of a tablet.
The invention discloses a compound traditional Chinese herbal medicinal drink for relieving effects of alcohol. The drink is prepared by blending purified water and extract liquids from the root of kudzu vine, Hovenia duleis Thunb fruit, orange peel, tropical fruit and citric acid. Each 100 ml of the drink comprises the components according to the following ratio: 1-1.5g of the root of kudzu vine, 0.9-1 g of Hovenia duleis Thunb fruit, 0.15-0.25 g of orange peel, 19-20 g of tropical fruit, 0.045-0.055 g of citric acid and 76-80 g of purified water. The drink provided by the invention is prepared by blending pure natural traditional Chinese medicinal materials and a small amount of western medicinal vitamins and adding a proper amount of tropical fruit as a sweetener. The drink has a unique mouthfeel, tastes fresh and cool, and has functions of clearing away heat and toxic materials, enhancing liver detoxification, enzymatic hydrolysis and dieresis, accelerating internal ethanolysis and discharge, increasing blood flow volume in cerebral and coronary vessels and relieving toxic symptom. Drunkenness can be prevented before people drink alcohol; and after people get drunk and then drink the product, drunkenness time can be shortened, discomfortable feelings such as gasteremphraxis and nausea, headache and dizziness, dry mouth and the like which are caused by drunkenness are relieved, increased heart rate and elevation of blood pressure which are caused by excessive drinking are alleviated, and liver injury caused by alcohol can be prevented.
OBJECTIVE: Alterations in gut microbiota have been implicated in the pathogenesis of ankylosing spondylitis (AS), but the underlying mechanisms remain elusive. This study aims to investigate changes in gut microbiota and metabolites in individuals with AS before and after treatment with secukinumab, to identify the biological characteristics specific to AS patients and investigate the potential biomarkers, for optimizing therapeutic strategies more effectively.
METHODS: Fecal microbiome data were collected from 30 AS patients before and after secukinumab therapy and compared with data from 40 healthy controls (HC). Additionally, we analyzed the metabolic profile of both groups from plasma.
RESULTS: Findings indicated that the treatment-induced changes in the composition of several crucial bacterial groups, including Megamonas, Prevotella_9, Faecalibacterium, Roseburia, Bacteroides, and Agathobacter. Post-treatment, these groups exhibited a distribution more akin to that of the healthy populations compared with their pretreatment status. We identified three gut microbial taxa, namely Prevotellaceae_bacterium_Marseille_P2831, Prevotella_buccae, and Elusimicrobiota, as potential biomarkers for diagnosing individuals at a higher risk of developing AS and assessing disease outcomes. Plasma metabolomics analysis revealed 479 distinct metabolites and highlighted three disrupted metabolic pathways. Integration of microbiome and metabolomics datasets demonstrated a significant degree of correlation, underscoring the impact of the microbiome on metabolic activity.
CONCLUSION: Secukinumab can restore the balance of the gut microbiome and metabolites in AS patients, rendering them more similar to those found in the healthy population. The analysis of microbiome and metabolomics data have unveiled some candidate biomarkers capable of evaluating treatment efficacy.
BACKGROUND AND OBJECTIVES: Spontaneous intracranial hypotension is recognized as a cause for refractory headache. Treatment can range from blind blood patch injection to microsurgical repair of the cerebrospinal fluid (CSF) leak. The objective of the study was to investigate the safety and efficacy of the targeted blood patch injection (TBPI) technique through a mini-open approach in treatment of refractory intracranial hypotension.
METHODS: We retrospectively reviewed cases of 20 patients who were treated for spontaneous intracranial hypotension at our institute between 2011 and 2022. Head and spine MRI and whole-spine myelography were performed in an attempt to localize the CSF leak. All patients underwent implantation of two epidural drains above and beneath the index level through a minimally invasive interlaminar microsurgical approach under general anesthesia. Then, blood patch was injected under clinical surveillance. Treatment success and surgical complications were evaluated postoperatively and at follow-up.
RESULTS: Patients presented with orthostatic headache, vertigo, sensory deficits, and hypacusis (95%, 15%, 15%, and 10%, respectively). Subdural effusions were present in 65% of the cases. A CSF leak was identified in all patients. The exact site of the CSF leak could be identified in 80% of cases. TBPI was performed with an average blood amount of 37.5 mL. A significant improvement of symptoms was reported in 90% of the cases. A total of 15% of the patients showed recurrent symptoms and underwent a second TBPI, resulting in symptom relief. No therapy-related complications were reported.
CONCLUSION: TBPI is a safe and efficient treatment for spontaneous intracranial hypotension. It is performed in a minimally invasive procedure and can be repeated, if necessary, with a very low-risk profile.
The investigators collected 189 plasma samples from 59 patients with metastasized CRPC treated with abiraterone/enzalutamide. In order to stratify plasma DNA samples based on the presence of low (i.e. z-score ≤5; corresponds to \<10% ctDNA) versus high (z-score \>5; corresponds to ≥10% ctDNA) genomic complexity in ctDNA the investigators employed the modified Fast Aneuploidy Screening Test-Sequencing System (mFAST-SeqS), which provides a plasma based marker of aneuploidy (z-score). Altogether 106 plasma samples with a low z-score will be evaluated only with the AVENIO ctDNA Expanded Kit, which is capable of detecting mutations with VAFs as low as 0.1% . From the 83 plasma samples with increased z-score will be sequenced with high coverage (70x) so that both mutations and nucleosome positions can be extracted from the obtained sequences. With the other 32 high z-score samples plasma-Seq will be conducted to establish genome-wide copy number profiles and 31 prostate cancer genes will be enriched to screen for mutations in these genes.

At present, there is no evidence what parameters should be used to decide which treatment options are best for metastatic prostate cancer patients. The suggested innovative technologies, i.e. nucleosome position mapping and gene expression analyses will provide systematic maps of nucleosome positions. The sequencing of plasma samples with 70x will provide in addition a comprehensive view on the mutation spectrum in metastatic prostate cancer. By inclusion of primary tumor analyses, an unprecedented view on prostate cancer genome Evolution will be obtained. Overall, the comprehensive data set (copy number changes, mutations, gene expression) will allow pathway analyses with unprecedented resolution.
PURPOSE: A pharmaceutical composition and a health functional food containing widdrol are provided to suppress proliferation and differentiation of pre-adipocytes and to effectively prevent and treat obesity. CONSTITUTION: A composition for suppressing proliferation and differentiation pre-adipocytes contains widdrol as an active ingredient. A composition for preventing and treating obesity contains widdrol as an active ingredient. The daily dose of widdrol in the composition is 100 ug/kg(body weight). The composition is manufactured in the form of an oral or parenteral formulation. A health functional food for preventing obesity contains widdrol. The health functional food is manufactured in the form of a powder, granules, a tablet, a capsule, a suspension, an emulsion, a syrup, a candy, snack, gum, ice cream, bread, and beverage.
PURPOSE: To suppress the metastasis of malignant tumor cell and microbial infection of warm blooded animals and prevent the conception of warm blooded animals by administering the animal with an agent for inhibiting carbohydratecarbohydrate interaction. CONSTITUTION: The cell-cell interaction or cell-substrate interaction of a warm- blooded animal is inhibited in vivo or in vitro by using an agent for inhibiting carbohydrate-carbohydrate interaction, e.g. a saccharide, a glyco-conjugate such as oligosaccharide linked to a peptide (e.g. lysyllysine) or an antibody against a carbohydrate determining group (preferably a monoclonal antibody). When one of the constituents of said interaction is present in the malignant tumor cell, the metastasis of the cell is suppressed and when it is present in a microorganism (bacteria, virus, true fungi or parasite), the infection with the microorganism is suppressed. The contraception of a warm blooded animal can be achieved by an agent effective for inhibiting a carbohydrate-carbohydrate interaction between the sperm and the ovum.
OBJECTIVES: Periprosthetic femur fractures after total knee arthroplasty in older adults are mostly treated by internal fixation. Members of the GETRAUM (French Orthopedic Trauma Society) sought to compare two surgical techniques - conventional open surgery and minimally invasive surgery - with the aim of analyzing the patients' functional recovery. We hypothesized that a minimally invasive technique would produce better early functional outcomes with recovery of independence.
MATERIALS AND METHODS: This retrospective multicenter study of patients treated between 2009 and 2015 consisted of 90 fractures with a follow-up of 1 year. Demographic, preoperative data and the characteristics of fractures, type of fixation and the surgeon's experience level were collected. The endpoints were the Parker Mobility score, Katz ADL, place of residence at the time of fracture and at 6 months and one-year follow-up. All complications and one-year mortality during the follow up were searched.
RESULTS: At 6 months follow-up, the minimally invasive technique contributed to significantly better functional recovery as measured by the Parker (p < 0.05) and Katz scores (p < 0.05). However, there were no differences in these scores at one-year follow-up. The complication rate was 31% at one year follow-up. Mortality rate was 12 % (11 patients).
CONCLUSION: Our hypothesis was confirmed, as there was a difference between techniques that impacted functional recovery and independence, but only in the early postoperative phase. A minimally invasive technique appears to be beneficial in the short term for distal femur fractures after total knee arthroplasty but must be evaluated in a comparative and prospective study to fully confirm its reliability.
Participants will receive GS1-144 5 mg, 15 mg, 30 mg, 60 mg and 90 mg tablets once on Day 1 in their respective Cohort in Part 1. 2 participants will receive placebo in each cohort.
The present invention discloses an activated biocidal aqueous solution containing hydrogen peroxide (activated peroxide solution) obtainable by subjecting an initial solution of hydrogen peroxide in water to a non-thermal electrical discharge process, such as a glow discharge plasma or a corona discharge. The resulting activated peroxide solution containing 0.05 to 20% (w/w) hydrogen peroxide has a pH in the range of 2 to 4, an oxidation-reduction potential (ORP) in the range of 400 to 600 mV, and the solution when having a peroxide content in the range of 0.05% to 0.5% (w/w) has a conductivity in the range of 100 to 500 μSiemens/cm, the solution when having a peroxide content in the range of 0.1% to 5% (w/w) has a conductivity in the range of 100 to 450 μSiemens/cm, and the solution when having a peroxide content in the range of 5% to 20% (w/w) has a conductivity in the range of 100 to 350 μSiemens/cm. The pH, ORP and conductivity are measurable under conditions essentially without the presence of additional compounds in the solution. The biocidal activity of the solution is substantially higher than that of a common peroxide solution. The biocidal solution may be used for any purpose where disinfecting and/or sanitizing and/or cleaning and/or bleaching and/or preservative activity is required. The present invention further discloses a non-thermal electrical discharge process, in particular a pulsed corona induced low frequency pulsed DC plasma discharge process, for the preparation of the activated peroxide solution.
Intermittent fasting (IF), one of the most popular diets, can regulate inflammation and promote health; however, the detailed molecular mechanisms are not fully understood. The present review aims to provide an overview of recent preclinical and clinical studies that have examined the effect of IF on inflammasome signaling, and to discuss the translational gap between preclinical and clinical studies. Three databases (PubMed, Web of Science, and Embase) were searched to identify all relevant preclinical and clinical studies up to October 30, 2022. A total of 1544 studies were identified through the database searches, and 29 preclinical and 10 clinical studies were included. Twenty-three of the 29 preclinical studies reported that IF treatment could reduce inflammasome activation in neurological diseases, metabolic and cardiovascular diseases, immune and inflammatory diseases, gastrointestinal diseases, and pulmonary diseases, and 7 of the 10 clinical studies demonstrated reduced inflammasome activation after IF intervention in both healthy and obese participants. Among various IF regimens, time-restricted eating seemed to be the most effective one in terms of inflammasome regulation, and the efficacy of IF might increase over time. This review highlights the regulatory effect of IF on inflammasome activation in health and disease. Future studies using different IF regimens, in various populations, are needed in order to evaluate its potential to be used alone or as an adjunct therapy in humans to improve health and counteract diseases.
Patients following-up at the PWH outpatient clinics will be enrolled for further evaluation via telephone follow-up at one, three, and six months after hospital discharge. SF12, EQ-5D-5L and work status standardized quantitative assessments of quality of life will be implemented via telephone follow-up at these time-points.
Protein-energy wasting (PEW) is a major contributor to the high mortality among maintenance hemodialysis (MHD) patients. Cardiovascular disease (CVD) is the leading cause of death in dialysis patients, and PEW can significantly increase cardiovascular mortality in MHD patients. Previous studies have confirmed that PA may be a good objective indicator for determining the nutritional status and prognosis of MHD patients. Our study aimed to determine the predictive value of phase angle (PA) as detected by bioelectrical impedance analysis (BIA) on PEW and cardiovascular (CV) risk among MHD patients. Our retrospective observational study involved 161 adult patients with HD. The Cardiovascular risk score is a risk model based on the Japan Dialysis Outcome and Practice Patterns Study (J-DOPPS). We established LASSO logistic regression analysis model to identify key parameters related to body composition that can predict PEW in MHD patients. The area under the curve (AUC) values for PA, appendicular skeletal muscle mass index (ASMI), body cell mass (BCM), and mid-arm circumference (MAC) in predicting PEW in male MHD patients were relatively large, with 0.708, 0.674, 0.663, and 0.735, respectively. The predicted PEW values of these parameters were slightly lower in female patients than in men. We incorporated PA, ASMI, BCM, and MAC into a model that predicted the incidence of PEW in maintenance hemodialysis patients using LASSO technology. We discovered that the model predicted a greater AUC of PEW occurrence than any single factor, 0.877 for men and 0.76 for women. The results of the univariate logistic regression analysis showed that the low PA tertile array group had a greater incidence of PEW than the high PA group (P < 0.001). Additionally, we also found that lower PA was associated with higher CV risk scores. The PA detected by bioelectrical impedance analysis could predict the risk of PEW and cardiovascular events among patients with MHD. When used in conjunction, PA, ASMI, BCM, and MAC have a high diagnostic efficacy for PEW in patients on maintenance hemodialysis.
Present invention concerns the specific gradual modification of signal proteins and peptides. By a combination of modification with the localization thereof with protease treatment and new forms of mass spectrometry, a very specific modification of the protein or peptide can be achieved. This enables the introduction of a desired change in biological activity, preferably an enhanced activity, an antagonistic activity and/or a cell inhibitory activity.  The antagonistic or cell inhibitory activity could be realized by chemical modification, namely an alkylation with specificity for His residues that were localized in or near a catalytic and/or Zinc binding center of human Interleukin-3. One that is skilled in the art can also easily use this invention to generate inhibitors and/or antagonists, preferably by molecular biological modifications, chemical modifications and/or alkylations, preferably by Iodo-Acetate. Preferably these modifications are directed against His residues, other catalytic residues and/or Zinc binding residues.  From additional results and data it can be deduced that the invention can also be applied easily on other signal substances. The results can also be well accomplished by DNA-constructs which also includes gene-therapy. Thus the presented methods, obtained substances and the use thereof are embodied in the invention.
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicaments or plant protection agents in the form of substrat es which, as functional groups, carry at least one amino or hydroxyl group. Sai d active ingredients can be obtained by means of a one-electron reaction which  is catalysed using enzymes or mixtures exhibiting enzymatic activity with a broad substrate spectrum. The method is characterised in that radical-formin g enzymes are used as enzymes, and/or supernatants of ligninolytic mushrooms i n an aqueous solution are used as mixtures exhibiting enzymatic activity. The following can be introduced in the form of additional functional groups: A) polyfunctional synthones which give the active ingredient a different soluti on behaviour in aqueous and lipophile systems, and high interfacial activity, B ) aromatic molecules and heteroaromatic compounds, C) heterocyclic compounds, D) active ingredients with independent biological efficacy, and E) active ingredients which bring together independent activity and surfactant properties in one molecule. Together, said additional functional groups and the starting products produce covalently linked coupling products exhibiting  modified distribution behaviour, by means of which polyfunctional interactio n with the target organism is made possible.
PURPOSE:To obtain the titled composition containing a mixture consisting of a polyfunctional monomer having a specific number or more of (meth) acryloyloxy groups and monofunctional monomer having cyclic ether bond in the side chain and a visible ray polymerization initiator. CONSTITUTION:The titled composition obtained by blending 100pts.wt. monomer consisting of 70-95wt% compound expressed by formula I (at least 4 of X are CH2=CHCOO- and the rest are -OH; m is 1-4; R is H or CH3) and 30-5wt% compound expressed by formula II or III (R1 is 2-3C alkylene; m and n are 0-5; x is 1-6; y is 0-4; z is 0-6) with 0.01-40pts.wt. visible ray polymerization initiator consisting of an aromatic mercaptocarboxylic acid, alpha-diketone and amine having a polymerizable unsaturated group. Plastic dentures having improved abrasion resistance, aesthetic feeling, etc., are readily obtained from the composition at a low cost. Surface characteristics are improved by coating the dentures with the composition and curing the composition.
The quality of drinks affects the functioning of the liver. In recent decades, the variety of high-calorie and sweet drinks has increased. The objective of this study was to explore the association between Healthy Beverage Index (HBI) and the risk of nonalcoholic fatty liver disease (NAFLD) among adults. We included 6,276 participants aged 35 to 65 from the Ravansar Non-Communicable Disease (RaNCD) cohort study at baseline. NAFLD is defined based on the fatty liver index (FLI), calculated using anthropometric measurements and non-invasive markers. The HBI was developed using a combination of water, low-fat milk, 100% fruit juice, sugar-sweetened beverages, met fluid requirement and % energy from beverages. Logistic and linear regression models were employed to investigate the associations of the HBI and high FLI. The average FLI was significantly lower in the first tertile of HBI compared to the third tertile (47.83 vs. 45.77; P = 0.001). After adjusting for confounding variables, the odds of high FLI decreased by 28% (OR 0.72, 95% CI 0.63, 0.82) in the second tertile of HBI and by 21% in the third tertile (OR 0.79, 95% CI 0.70, 0.91). There was no correlation between gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST) levels with HBI. The study findings indicate an inverse association between high FLI and HBI. Therefore, it is recommended to consume healthy beverages and without added sugar. However, additional longitudinal studies are required to examine the association between beverage consumption and the development of NAFLD.
<P>PROBLEM TO BE SOLVED: To provide a hair-treating method which can enhance an effect for inhibiting the fading of hair dyed with an oxidation hair dye and can easily inhibit the deterioration in the flexibility of the hair, and to provide a post-treating agent kit.  <P>SOLUTION: At the first post-treating stage, the first post-treating agent is applied to hair wetted by washing away an oxidation hair dye. At a dry treating stage, the hair after the first post-treating stage is dried. At the second post-treating stage, the second post-treating agent is applied to the hair after the dry treating stage. The first and second post-treating agents contain a cationized chitosan and a surfactant. The surfactant is at least one selected from amphoteric surfactants having ≤18C alkyl groups, and cationic surfactants having ≤18C alkyl groups. The first post-treating agent contains the cationized chitosan in a larger mass rate than the cationized chitosan in the second post-treating agent. The post-treating agent kit is formed by containing the first and second post-treating agents.  <P>COPYRIGHT: (C)2011,JPO&INPIT