anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Fibromyalgia is a common, chronic musculoskeletal disorder that is characterized by widespread pain and tenderness. Fibromyalgia occurs in around 2% of the US general population, is more common in women and is associated with substantial morbidity and disability. Treatment of fibromyalgia has been disappointing; roughly one-third of patients have had a clinically important therapeutic response to medications or no-medicinal treatment, event with the newest drugs reported in the literature. Pathophysiology of fibromyalgia is unknown, but abnormalities in central neurotransmission might play a role. Some studies have shown that salmon calcitonin increases peripheral and central levels of endorphins. Increasing endorphins levels may decrease pain. Then, it is feasible that nasal administered salmon calcitonin may decrease several of the symptoms and signs of patients suffering fibromyalgia.
The invention takes the traditional Chinese medicine theory as guidance, and based on the achievement of modern process technology, the invention aims to creat and help to solve a sub-health weight-losing scheme which is safe and effective, has proper cost, is convenient to take and treats based on syndrome differentiation. It is used as the main product in the Zhen Zhu Sheng Jiang Jian Jiang Jiao (Capsule for eliminating turbid discharge and reducing weight). The basic prescription is composed of prepared rhubarb, frosted croton, hawthorn, rhizoma alismatis, orange peel, liquorice and other Chinese herbal medicines. It has effects of relaxing bowels, removing toxic substances, invigorating qi and spleen, removing blood stasis, reducing blood lipid, eliminating phlegm and eliminating dampness. Can be used for treating various simple obesity, habitual constipation, hyperlipidemia, and damp turbidity deficiency syndrome. The usage and dosage are as follows: 1-2 granules/time, 1-2 times/day, in proper degree; or following the medical advice. Based on the main formula, the treatment can be carried out according to syndrome differentiation by adding or subtracting the medicinal flavors aiming at two different constitutional symptoms of fat turbidity and damp turbidity. It is worth noting that energy intake during weight reduction should be less than energy consumption, staple food is reduced in a balanced manner, vegetables and fruits are eaten more frequently, and the staple food is kept constant step by step, so that a good habit is formed, and real health is obtained. The product is used for removing turbid pathogen and losing weight, has no pain, damage or side effect, and is a health care product integrating prevention, maintenance and treatment.
During the Cumulative Irritation portion of the study there will be 7 patches (2 product patches, 2 vehicle controls, 1 positive control, 1 low-irritancy control, and 1 empty patch). The low-irritancy control patch will be a saline patch. The positive control will be a SLS patch. The negative control will be an undosed patch.
The invention relates to a new application of daucosterol in medicine and health care product preparation, in particular to application of daucosterol in preparing medicines and health care products for promoting proliferation of neural stem cells. The daucosterol is a phytosterol derivative and is sitosterol-3-O-glucoside which widely exists in plants, and the processes of extracting, separation and content detection are simple and convenient. According to research, the medicines can promote proliferation of osteoblastlike cells, protect endothelial cells of human capillaries and further can reduce blood sugar activity. By means of the application, primarily-cultured neural stem cells and aged mice serve as the materials, and users can observe the effect of daucosterol on the neutral stem cells. In-vitro experiments and integral experiments prove that the daucosterol has the effect of promoting proliferation of the neutral stem cells. In the in-vitro experiments, the daucosterol with the dose ranging from 10 mu mol/L to 100 mu mol/L can promote proliferation of the neutral stem cells, and in the integral experiments, the daucosterol with the dose of 10mg/kg can promote proliferation of the neutral stem cells of the aged mice.
BACKGROUND: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities (including obesity, insulin resistance, hypertension, and dyslipidemia), which can be used to identify at-risk populations for diabetes and cardiovascular diseases, the main causes of morbidity and mortality worldwide. The achievement of a simple approach for diagnosing MetS without needing biochemical tests is so valuable. The present study aimed to predict MetS using non-invasive features based on a successful random forest learning algorithm. Also, to deal with the problem of data imbalance that naturally exists in this type of data, the effect of two different data balancing approaches, including the Synthetic Minority Over-sampling Technique (SMOTE) and Random Splitting data balancing (SplitBal), on model performance is investigated.
RESULTS: The most important determinant for MetS prediction was waist circumference. Applying a random forest learning algorithm to imbalanced data, the trained models reach 86.9% and 79.4% accuracies and 37.1% and 38.2% sensitivities in men and women, respectively. However, by applying the SplitBal data balancing technique, the best results were obtained, and despite that the accuracy of the trained models decreased by 7.8% and 11.3%, but their sensitivity improved significantly to 82.3% and 73.7% in men and women, respectively.
CONCLUSIONS: The random forest learning method, along with data balancing techniques, especially SplitBal, could create MetS prediction models with promising results that can be applied as a useful prognostic tool in health screening programs.
Disclosed are low-modification biocompatible high polymer sulfhydryl-modified derivatives. The derivatives have a very low degree of sulfhydryl modification, and maintain to the greatest extent possible the initial structure, physiological function, and biocompatibility of the biocompatible high polymer. At the same time, the sulfhydryl introduced effectively carries out chemical cross-linking so as to produce a biocompatible high polymer cross-linked material having a low degree of cross-linking. Also disclosed is a type of disulfide cross-linked biocompatible high polymer cross-linked material. This cross-linked material has a low degree of cross-linking and not only maintains to the greatest extent possible the initial structure, physiological functions, and biocompatibility of the biocompatible high polymer, but also delays metabolization of the biocompatible high polymer in the body and reduces solubility. This satisfies a variety of needs in terms of clinical application. The present invention relates also to the use of disulfide cross-linked biocompatible high polymer cross-linked material in medical science and pharmacology.
Speech therapy makes an integral part of the non-pharmacological, conservative management of Post stroke aphasia. Routine speech therapy aims to improve comprehension and verbal skills and also develop functional communication skills through augmentative Alternative communication devices. Disorders of communication, including aphasia (mainly post stroke) caused by the left hemisphere brain damage, is a major community health issue. Aphasia is a language disorder occurring mainly as a result of stroke. It is an acquired impairment of language that weakens people's ability of comprehension and expression, it does not show any affect to intellect ability. The verbal expressive skills management programme (VESMP) is the software which developed augmented management for patients to enhance verbal expressive skills for patients with severe Broca's aphasia from different geographic areas.
CMV retinitis is one of the most common opportunistic infections in patients with AIDS. DHPG is at present the only drug available for widespread compassionate use in the United States. Although most patients respond to treatment with DHPG, the medication does not cure the infection. Most patients will have a relapse and will require retreatment with DHPG. Because of the large relapse rate, most people treated for CMV retinitis are placed on continuous treatment with DHPG. There are two major problems associated with ongoing use of DHPG: 1) The development of a low white blood cell (WBC) count (leukopenia) which is a known side effect of the drug; and 2) the increased risk for leukopenia when DHPG is given together with AZT, the only antiviral drug currently available for the treatment of HIV infection. Therefore, patients cannot take both AZT and DHPG at the same time because the bone marrow toxicity is made much more severe when the drugs are given together. This has resulted in the difficult decision as to whether to forgo potential life-extending therapy with AZT in order to preserve sight. An effective treatment for CMV retinitis is needed that will allow the patient to also take AZT. ACV is presently the drug of choice for severe herpes virus infections. It has been shown to be effective in suppressing severe CMV disease in patients who have received bone marrow transplants.

Patients receive ACV intravenously and AZT orally for 12 weeks. Tolerance of the combined administration of ACV and AZT is monitored. AMENDED: AZT dose lowered and inclusion of concurrent medication expanded.
A Cdna clone of 744 bp encoding a copper / zinc-superoxide dismutase (Cu/Zn-SOD) from lemon was cloned by PCR approach. Nucleotide sequence analysis of this Cdna clone revealed that it comprise an open reading frame coding for 152 amino acid residues. The coding region (or fused with 9 amino acid residues to N-terminal, namely Tat) was subcloned into an expression vector and transformed into E.coh or yeast. The expression of the Cu/Zn-SOD (or Tat-Cu/Zn-SOD) was confirmed by enzyme activity staining on a native-gel and purified by Ni2± nitrilotriacetic acid Sepharose superflow. The thermal inactivation rate constant Kd value at 90 DEG C was -0.007 min-1, and half-life for inactivation was 99 min. Both activity and forms of the enzyme were not affected by acidic , basic Ph or 4 % SDS. The enzyme was also resistant to proteolytic attack with trypsin or chymotrypsin. Lemon Cu/Zn-SOD can eliminate the superoxide free radical,on surface of skin and cooperates with the abundant vitamin C in lemon to reduce the melanin and brighten the skin. Due to its novel stability and resistance, the lemon SOD may be used for many applications, such as skin-whiting agent by lemon directly or lotion with purified lemon SOD.There were many reports using superoxide dismutase in cosmetic with porphyrin or even melanin for the protection of the skin, hair and/or mucosae against the harmful and/or unaesthetic effects caused by oxygen-containing free radicals. Lemon SOD immersed in liposome administrated by oral may prevent inflammation and remove the free radical in gastrointestinal tract to protect the diarrhea, their possible uses as burn or ulcer healing and immunomodulating agents.
The objective of this study was to identify genomic regions and genes associated with resistance to gastrointestinal nematodes in Australian Merino sheep in Uruguay, using the single-step GWAS methodology (ssGWAS), which is based on genomic estimated breeding values (GEBVs) obtained from a combination of pedigree, genomic, and phenotypic data. This methodology converts GEBVs into SNP effects. The analysis included 26,638 animals with fecal egg count (FEC) records obtained in two independent parasitic cycles (FEC1 and FEC2) and 1700 50K SNP genotypes. The comparison of genomic regions was based on genetic variances (gVar(%)) explained by non-overlapping regions of 20 SNPs. For FEC1 and FEC2, 18 and 22 genomic windows exceeded the significance threshold (gVar(%) ≥ 0.22%), respectively. The genomic regions with strong associations with FEC1 were located on chromosomes OAR 2, 6, 11, 21, and 25, and for FEC2 on OAR 5, 6, and 11. The proportion of genetic variance attributed to the top windows was 0.83% and 1.9% for FEC1 and FEC2, respectively. The 33 candidate genes shared between the two traits were subjected to enrichment analysis, revealing a marked enrichment in biological processes related to immune system functions. These results contribute to the understanding of the genetics underlying gastrointestinal parasite resistance and its implications for other productive and welfare traits in animal breeding programs.
The efficacy of diclofenac potassium in adults was demonstrated in two multicenter, randomized, double-blind, placebo- controlled, parallel arm, multiple-dose clinical trials comparing diclofenac potassium 25 mg and placebo in patients with pain following bunionectomy with osteotomy. Once patients met the criteria for randomization (pain intensity ≥4 on a 0 to 10 numerical pain rating scale) they received their initial dose of study medication followed by a remedication dose when requested by the patient, and were then dosed every six hours over four days. Pain intensity was recorded at 3 and 6 hours postdose during the fixed dosing period. In Study 1, mean baseline pain intensity scores were 6.9 in the diclofenac potassium group (range: 4 to 10) and 7.3 in the placebo group (range: 4 to 10). In both studies, patients treated with diclofenac potassium had a lower mean pain intensity score over the 48-hour inpatient period following the first remedication dose (see Figure 1). The median time to onset of pain relief was less than one hour for diclofenac potassium 25 mg across the clinical trials. The results were similar in Study 2.  
  
Figure 1 Mean Pain Intensity Scores at the Midpoint and End of Each Dose Interval in Postbunionectomy Pain Study 1
Lymphocytes which are toxic to cancer cells and specific for a glyco- related antgen (GRA) of such cells are prepd. by sensitising leucocytes to a GRA.  GRA is isolated from human cancer cells by complexing with a lectin e.g. groundnut or soya lectin for galactose specificity, or Dolictis agglutin or Luma bean lectin for acethylgalactosamine.  Particulary the GRA is a component of cancer cell membranes and combines with a lectin specifically at the galactose or N-acetylgalactosamine terminal gp.  Sensitised cells destroy cancer cells carrying the corresponding GRA and are specific since GRA do not occur on normal cells.
The invention discloses a method for mining the relation between a medicine pair and efficacy from prescription information. The method comprises the following steps: 1) Authoritative prescription information data is collected, wherein the data comprises prescription efficacy main treatment information and traditional Chinese medicine composition information. 2) And the data is cleaned and structured, so that the subsequent model training and information mining are facilitated. 3) And (3) constructing a data mining model, fitting the samples, and learning parameters with strong interpretability. 4) And acquiring the interpretive parameters learned by the model, performing subsequent filtering treatment, removing noise, reserving medicine pair information, and mining the relation between the medicine pair and efficacy. According to the invention, a heuristic strategy is adopted for filtering, the association degree between the efficacy and the drug pair is measured according to the efficacy prediction accuracy, and most of invalid relations can be removed.
FIELD: medicine. SUBSTANCE: method involves applying Polygonum aviculare L. s.I knot-grass extract for improving ejaculate quality. The means has 10% of extractive substances containing in Polygonum aviculare L.s.I knot-grass extract as active base. The drug is to be administered for normalizing spermatogenesis at a dose of 12.0-10.0 g daily during the full cycle of spermatogenesis. EFFECT: enhanced effectiveness in treating male infertility; simplified method. 3 cl, 8 tbl
BACKGROUND: Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both alcohol consumption and serum urate or gout in separate genome-wide association studies (GWAS). This study aimed to identify and characterise interactions between these shared signals of genetic association and alcohol consumption for serum urate level, hyperuricaemia, and gout.
METHODS: This research was conducted using the UK Biobank resource. The association of alcohol consumption with serum urate and gout was tested among 458,405 European participants. Candidate SNPs were identified by comparing serum urate, gout, and alcohol consumption GWAS for shared signals of association. Multivariable-adjusted linear and logistic regression analyses were conducted with the inclusion of interaction terms to identify SNP-alcohol consumption interactions for association with serum urate level, hyperuricaemia, and gout. The nature of these interactions was characterised using genotype-stratified association analyses.
RESULTS: Alcohol consumption was associated with elevated serum urate and gout. For serum urate level, non-additive interactions were identified between alcohol consumption and rs1229984 at the ADH1B locus (P = 3.0 × 10-44) and rs6460047 at the MLXIPL locus (P = 1.4 × 10-4). ADH1B also demonstrated interaction with alcohol consumption for hyperuricaemia (P = 7.9 × 10-13) and gout (P = 8.2 × 10-9). Beer intake had the most significant interaction with ADH1B for association with serum urate and gout among men, while wine intake had the most significant interaction among women. In the genotype-stratified association analyses, ADH1B and MLXIPL were associated with serum urate level and ADH1B was associated with hyperuricaemia and gout among consumers of alcohol but not non-consumers.
CONCLUSIONS: In this large study of European participants, novel interactions with alcohol consumption were identified at ADH1B and MLXIPL for association with serum urate level and at ADH1B for association with hyperuricaemia and gout. The association of ADH1B with serum urate and gout may occur through the modulation of alcohol metabolism rate among consumers of alcohol.
Patients receive a handout describing behavioral management tips for urinary incontinence, including information and suggestions about optimal volume fluid intake, constipation management, measures to reduce urgency by spreading fluid intake, and avoiding caffeine and other bladder irritants that have proved effective in other intervention trials. Patients undergo PFMT over 20-30 minutes teaching them to contract the pelvic floor muscles correctly and receive feedback to avoid the contraction of abdominal, gluteal or adductor muscles. Patients are asked to perform 3 sets of 10 pelvic muscle contractions with a goal of holding the contraction for 5 seconds daily for 12 weeks and also receive a reminder phone call to address concerns and review the instructions at 4 weeks.
The invention relates to the technical field of medicines, in particular to a blood circulation activating and stasis removing fermented wine. The invention fully utilizes the characteristics of medicinal materials, changes the traditional mode and shows better advanced technology. In the use of lapis Chloriti, the traditional method is to use lapis Chloriti Dan Duanshao. From ancient times, doctors thought that lapis Chloriti did not calcine and did not play the role of medicine. However, the inventor does not operate in the traditional way, but utilizes the characteristic that lapis Chloriti is decomposed when meeting acid, and the medicinal components of lapis Chloriti are fully decomposed through the reaction process of saccharification and acidification, so that a good effect is achieved. Shows advancement, science and technology, and has unique and innovative characteristics. Through a series of operation steps, the sweet medicinal liquor capable of treating diseases is perfectly produced, and the method has scientificity and advancement. The sweet wine has the effects of promoting blood circulation to remove blood stasis and dredging blood vessels, has good curative effect on treating coronary heart disease, and is sour, sweet and delicious.
Sepsis-induced acute liver injury (SALI), a manifestation of sepsis multi-organ dysfunction syndrome, is associated with poor prognosis and high mortality. The diversity and plasticity of liver macrophage subpopulations explain their different functional responses in different liver diseases. Kupffer macrophages, liver capsular macrophages, and monocyte-derived macrophages are involved in pathogen recognition and clearance and in the regulation of inflammatory responses, exacerbating the progression of SALI through different pathways of pyroptosis, ferroptosis, and autophagy. Concurrently, they play an important role in maintaining hepatic homeostasis and in the injury and repair processes of SALI. Other macrophages are recruited to diseased tissues under pathological conditions and are polarized into various phenotypes (mainly M1 and M2 types) under the influence of signaling molecules, transcription factors, and metabolic reprogramming, thereby exerting different roles and functions. This review provides an overview of the immune role of macrophages in SALI and discusses the multiple roles of macrophages in liver injury and repair to provide a reference for future studies.
Vocal communication depends on distinguishing self-generated vocalizations from other sounds. Vocal motor corollary discharge (CD) signals are thought to support this ability by adaptively suppressing auditory cortical responses to auditory feedback. One challenge is that vocalizations, especially those produced during courtship and other social interactions, are accompanied by other movements and are emitted during a state of heightened arousal, factors that could potentially modulate auditory cortical activity. Here, we monitor auditory cortical activity, ultrasonic vocalizations (USVs), and other non-vocal courtship behaviors in a head-fixed male mouse while he interacts with a female mouse. This approach reveals a vocalization-specific signature in the auditory cortex that suppresses the activity of USV playback-excited neurons, emerges before vocal onset, and scales with USV band power. Notably, this vocal modulatory signature is also present in the auditory cortex of congenitally deaf mice, revealing an adaptive vocal CD signal that manifests independently of auditory feedback or auditory experience.