anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Turner syndrome (TS) affects approximately 1 in 2500 female live births globally, making it the most common sex chromosomal abnormality in females. It results from a partially or completely missing X chromosome, often occurring in mosaic karyotypes. TS is associated with various health issues, including short stature, delayed puberty, ovarian dysgenesis, hypergonadotropic hypogonadism, infertility, congenital heart defects, endocrine disorders and autoimmune disorders. TS is less prevalent among twins. Since the first case report in 1938, the association between TS and twinning has been noted in only 30 cases worldwide. However, only six reports exist of monozygotic non-mosaic twins with TS, all 45,XO. Although TS affects individuals worldwide, the literature on TS in Asian twins is sparse, with no reported cases from Asia. This scarcity underscores the need for further research to understand this region's epidemiology and challenges. This case report highlights the importance of evaluating both twins if one is diagnosed with TS.
This work was designed as a prospective case series clinical study. Twenty patients have been consecutively rehabilitated with an immediately loaded oral implant supported fixed full prosthesis. A total of 120 oral implants (Nobel Replace Tapered Groovy; Nobel Biocare AB, Goteborg, Sweden) supporting 23 bridges (8 mandible, 15 maxilla) were placed , 22 of which in fresh post extraction sockets. 117 out of 120 oral implants were immediately loaded.
BACKGROUND: Gastric cancer (GC) is a common cancer worldwide; however, its molecular and pathogenic mechanisms remain unclear. MicroRNAs (miRNAs), which target key genes in GC, are associated with tumor promotion or suppression. Therefore, identifying new miRNA mechanisms could improve the novel diagnostic and therapeutic strategies for patients with GC.
METHODS: To explore the biological functions of miR-135b-5p in GC, bioinformatic analysis and in vitro functional assays, including colony formation, wound healing, Transwell, and EdU assays, were used to assess the proliferative, invasive, and migratory capacities of GC cells. Target genes were predicted using RNA-seq and online databases. Dual-luciferase reporter assay, fluorescence in situ hybridization and western blotting were used to confirm the regulatory relationship between miR-135b-5p and CLIP4. The role of CLIP4 in tumor progression was assessed using clinical samples and both in vitro and in vivo assays. The tumor-suppressive mechanism of CLIP4 in GC was elucidated using rescue assays.
RESULTS: Our study identified that miR-135b-5p as one of the top three over-expressed miRNAs in GC tissues, with RT-qPCR confirming its upregulation. Functional analysis showed that upregulated miR-135b-5p promoted malignant phenotypes in GC cells. Mechanistic research indicated that miR-135b-5p acts as a cancer promoter by targeting CLIP4. Moreover, our study suggested that CLIP4 exerts its tumor-suppressive function by inhibiting the JAK2/STAT3 signaling pathway.
CONCLUSION: This study reveals a novel mechanism by which miR-135b-5p exerts its tumor-promoting functions by targeting CLIP4. The tumor-suppressive function of CLIP4 by inactivating the JAK2/STAT3 pathway is also elucidated. Regulatory mechanism of CLIP4 by miR-135b-5p provides a promising novel therapeutic strategy for GC patients.
PURPOSE: Provided is a glucose derivative complex compound in which the glucose derivative contains nitrogen or sulfur atom in its molecule, and is labeled with a radioactive isotope. And, a kit article including the glucose derivative and a reductant is also provided to produce the same. The compound has an excellent absorbability into a tumor region and is produced cost effectively, thereby being useful as a diagnosis reagent for tumor. CONSTITUTION: In a glucose derivative complex compound, the glucose derivative containing nitrogen or sulfur atom in its molecule is labeled with at least one radioactive isotope selected from the group of(99m)Tc,(188)Re, and(186)Re. Wherein, the glucose derivative is selected from the group consisting of 1-thio-D-glucose, 5-thio-D-glucose, glucosamine, and their salts or hydrates. The kit article comprises the glucose derivative including nitrogen or sulfur atom in its molecule and a reductant selected from the group of tin chloride(II), formamidine sulfuric acid, sulfuric acid and sodium borohydride. Optionally it includes an additive selected from the group consisting of ascorbic acid, sodium bisulphite and sodium pyrosulphite.
PURPOSE:To simplify the work of an operator and to reduce his burden by automatically obtaining an optinum gradation conversion curve and performing gammacorrection in accordance with this conversion curve only by designating an area on a displayed image. CONSTITUTION:An original image in a state that a gamma correction circuit 5 is not interposed is displayed by an image display device 3 and arbitrary areas A, B are designated by the operation of a mouse 4. The densities of the average value and the peak value within each area of these points A, B are read by a CPU 2 and inputted in an approximate expression calculation circuit 6. Then, the circuit 6 determines a polynomial showing the input/output characterisitic curve from these two point data by an approximate calculation. A data calculation circuit 1 calculates each value of the output image data corresponding to each value of input image data from this polynomial. A writing circuit 8 designates the address corresponding to each value of input image data and writes each output image data in the gamma correction circuit 5. Therefore, a gradation conversion is performed for image data via the circuit 5.
NEW MATERIAL:A glycoprotein originated from human cell membrane, having a molecular weight of 20-25Kd measured by SDS-polyacrylamide electrophoresis, containing N-glycoside-type sugar chain and phosphatidyl inositol and effective in suppressing the damage of cell membrane caused by a complement. USE:Useful for the preparation of a stable monoclonal antibody against membrane protein participating in the control of the activity of complement, the diagnosis of diseases such as pernicious anemia, the remedy for diseases in which the activation of complement is participated, the lysis of cancer cell, etc. PREPARATION:Human cells such as erythrocytes are collected by centrifugation and disintegrated in a hypotonic solution by osmotic pressure. The obtained disintegrated liquid is added with a hypotonic solution and subjected to centrifugal separation to collect a cell membrane fraction. The membrane protein is extracted from said fraction with a buffer solution containing a surfactant, etc., and the extract liquid is added with ammonium sulfate. The fraction precipitated by the ammonium sulfate is purified by column chromatography.
Clear cell meningiomas are a rare histological subtype of World Health Organization (WHO) grade II meningioma. Despite its relatively low frequency, clear cell meningioma has attracted considerable attention because of its unique pathological characteristics, clinical behavior, and challenging management considerations. The purpose of our systematic review is to provide clinicians with a better understanding of this rare disease. PubMed was searched for articles in the English language published from 1988 to 2023 June. The keywords were as follows: "clear cell meningioma," "clear cell" and "meningioma." We analyzed clinical manifestations, radiological manifestations, pathological features, comprehensive treatment strategies, and prognosis to determine the factors influencing recurrence-free survival (RFS). Recurrence-free survival curves of related factors were calculated by the Kaplan‒Meier method. The log-rank test and Cox univariate analysis were adopted to assess the intergroup differences and seek significant factors influencing prognosis and recurrence. Fifty-seven papers met the eligibility criteria, including 207 cases of clear cell meningioma (CCM), which were confirmed by postoperative pathology. The fifty-seven articles involved 84 (40.6%) males and 123 (59.4%) females. The average age at diagnosis was 27.9 years (range, 14 months to 84 years). Among the symptoms observed, headache, neurologic deficit, and hearing loss were the most commonly reported clinical manifestations. Most tumors (47.8%) were located in the skull base region. Most tumors showed significant enhancement, and homogeneous enhancement was more common. A total of 152 (74.1%) patients underwent gross total resection (GTR), and 53 (25.9%) patients underwent subtotal resection (STR). During the follow-up, the tumor recurred in 80 (39.4%) patients. The log-rank test and the Cox univariate analysis revealed that tumor resection range (GTR vs. STR) and adjuvant treatment (YES vs. NO) were significant predictors of recurrence-free survival (RFS). Clear cell meningioma is a rare type of meningioma with challenging diagnosis and therapy. The prognosis of this disease is different from that of regular meningiomas. Recurrence remains a possibility even after total tumor resection. We found that the surgical resection range and adjuvant treatment affected the recurrence period. This finding provides significant guidance for the treatment of clear cell meningioma.
<P>PROBLEM TO BE SOLVED: To solve the problem that various conventional cosmetic treatment methods of scalp are used exclusively for hair care, expected to serve only for maintenance of present status and temporary recovery of hair, and can not succeed in attaining essential hair care and improvement of scalp.  <P>SOLUTION: A head is soaked in a highly concentrated carbonate warm water having a carbon dioxide gas concentration of 500 ppm or more at 30°C or above preferably for 20 min or more to improve bloodstream in a subcutaneous blood capillary and activate metabolism in scalp. The every day treatment may develop the subcutaneous blood capillary toward the scalp to allow permanent hair care and improve the scalp. In order to facilitate the bathing of scalp in the highly concentrated carbonate warm water, a system and a packing for protecting liquid leakage are used to carry out the bathing of the head in carbonate warm water for about 20 min. A cap-like vessel is put on the head and filled with the highly concentrated carbonate warm water to keep the head skin in direct contact with the highly concentrated carbonate warm water for about 20 min. The method and the apparatus are provided to allow simple cosmetic treatment of the head with the carbonate warm water.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Posttraumatic stress disorder (PTSD) is prevalent among Veterans and is a substantial public health burden. Several psychotherapies, including cognitive processing therapy (CPT), have a strong evidence base for their efficacy in PTSD. However, many individuals show limited benefit from such treatments, particularly older Veterans. One factor likely affecting treatment response is poor encoding, storage, and retrieval of the skills and treatment points that are learned in psychotherapy. Individuals with PTSD display deficits in learning and memory, and aging is independently associated with declines in memory and executive functioning. Thus, older adults with PTSD may be at heightened risk of cognitive dysfunction that could impact their ability to benefit from frontline PTSD treatments. To this end, pre-treatment memory functioning has been shown to consistently predict treatment response in psychotherapy for PTSD. Inefficient learning and memory for psychotherapy content may be one mechanism explaining this relationship, as poor learning of therapy content is linked with worse treatment adherence and outcomes. The primary aim of this proposal is to examine the feasibility and acceptability of integrating a novel Memory Support intervention into the provision of CPT for older adults with PTSD. The Memory Support intervention was developed such that specific strategies to enhance encoding and retrieval of therapy content and skills can be integrated into manualized psychotherapy. However, no prior studies have integrated this intervention into treatments for PTSD. The proposed project will be guided by a user-centered design framework for treatment development and be conducted in three phases. In the first phase, the investigators will develop a modified CPT treatment manual that systematically integrates Memory Support, with clinician (n=3) and Veteran (n=3) feedback to provide guidance on process and techniques. In the next phase, the investigators will conduct iterative refinement of the modified treatment through a case series in older Veterans (n=3) with an experienced CPT therapist. Finally, the investigators will conduct a small feasibility randomized controlled trial (n=20) in which the investigators will examine accrual, retention, completion, acceptability, and variability in symptom and functional outcomes, as well as all procedures for a larger trial. The proposed project offers substantial conceptual innovations by bridging foundational work from rehabilitation neuropsychology and psychotherapy mechanisms research and will provide valuable pilot data to inform a novel intervention for older Veterans with PTSD that can be tested in future large-scale studies. Such approaches may be especially relevant for Veterans with neurocognitive deficits (e.g., memory), potentially suggesting a target for a personalized approach to mental health care.
Withdraw the bolus volume from the diltiazem hydrochloride infusion bag and administer it over 2 minutes. The initial dose of diltiazem hydrochloride should be 0.25 mg/kg actual body weight as a bolus administered over 2 minutes (20 mg is a reasonable dose for the average patient). If response is inadequate, a second dose may be administered after 15 minutes. The second bolus dose of diltiazem hydrochloride should be 0.35 mg/kg actual body weight administered over 2 minutes (25 mg is a reasonable dose for the average patient). Subsequent intravenous bolus doses should be individualized for each patient. Patients with low body weight should be dosed on a mg/kg basis.
Cambodia has made progress in reducing the under-five mortality rate and burden of infectious diseases among children over the last decades. However the determinants of child mortality and morbidity in Cambodia is not well understood, and no recent analysis has been conducted to investigate possible determinants. We applied a multivariable logistical regression model and a conditional random forest to explore possible determinants of under-five mortality and under-five child morbidity from infectious diseases using the most recent Demographic Health Survey in 2021-2022. Our findings show that the majority (58%) of under-five deaths occurred during the neonatal period. Contraceptive use of the mother led to lower odds of under-five mortality (0.51 [95% CI 0.32-0.80], p-value 0.003), while being born fourth or later was associated with increased odds (3.25 [95% CI 1.09-9.66], p-value 0.034). Improved household water source and higher household wealth quintile was associated with lower odds of infectious disease while living in the Great Lake or Coastal region led to increased odds respectively. The odds ratios were consistent with the results from the conditional random forest. The study showcases how closely related child mortality and morbidity due to infectious disease are to broader social development in Cambodia and the importance of accelerating progress in many sectors to end preventable child mortality and morbidity.
PURPOSE: To obtain a stabilized sorbic acid or its salt for an antimicrobial agent, etc., by preparing a stabilized aq. soln. contg. sorbic acid or its salt in an antimicrobial ratio and manganous ions enough to prevent the oxidation of the sorbic acid or its salt to acetaldehyde. CONSTITUTION: Sorbic acid (2,4-hexadienic acid) or its salt such as potassium sorbate is added to water in an antimicrobial ratio and manganese sulfate is further added so as to attain 0.1-5 ppm concn. of manganous ions. Sucralose, sodium benzoate, citric acid, sodium citrate, etc., are then dissolved in the resultant aq. soln. contg. manganous ions enough to prevent the oxidation of the sorbic acid or its salt to acetaldehyde to obtain the objective stabilized srobic acid or its salt contg. low concn. manganous ions as a stabilizer and useful for an antimicrobial agent for food, pharmaceuticals and products for promotion of health.
Consented patients receiving monthly bi-lateral injections of the same dose of ranibizumab will have one eye injected with a 30 gauge needle and the other eye injected with a 32 gauge needle. Bi-lateral injections may be performed on the same day or with one week of each other, depending on the subject preference and their normal injection regimen. On the first visit following enrollment in the study, the eye to receive the injection from the 30 or 32 gauge needle will be determined randomly. The other eye will be injected with the other needle size (may be that day or within 1 week of the 1st injection). When the patient returns for their next set of bi-lateral injections, the eyes receiving the 30 and 32 gauge needle injection will switch.
The medial plantar artery flap (MPAF) presents both unique value as well as significant challenges. As the plantar foot has specific anatomy, the use of the MPAF to recreate this highly specialized area may provide improvements in durability and rates of limb salvage. The purpose of this study is to establish the anatomic course of the branching patterns of the medial plantar artery (MPA) and provide a foundation for MPA flap nomenclature as it is related to design and elevation. Thirty-seven fresh frozen cadaver feet were used for dissection: 20 right and 17 left sided limbs. Anatomic measurements recorded included: branching pattern of the MPA, bifurcation distance of the superficial branch (SB) and deep branch (DB) from the origin of the MPA, distance from the MPA origin to the anterior colliculus of the medial malleolus, and the distance from the SB and the DB to the navicular tuberosity. The MPA was found to bifurcate into SB and DB in 30 (81%) specimens; 6 (16%) specimens had only a SB, whereas 1 (3%) specimen had only a DB, which had not been previously described. The distance from the anterior colliculus to the MPA was 3.0 cm, MPA to the distal bifurcation was 2.9 cm, and navicular tuberosity to the SB and DB was 2.2 cm and 1.3 cm, respectively. Minimizing the complexity of the dissection with the use of more reliable landmarks and a deeper understanding of the anatomy may reduce complications and allow for more reproducible outcomes when utilizing the MPAF.
Rates of suicide among young Alaska Native males are over ten-fold higher than among a similar age cohort in the rest of the United States. A high proportion of these deaths are associated with firearms. Firearms are an important part of the subsistence lifestyle of this population, however restriction of access to guns by youth may be a promising strategy to reduce the risk of suicides in this population. Recent work by the HIPRC has shown that locked guns are associated with a 73% reduced risk of suicide, compared to unlocked guns. Similar protective associations were found for unloaded guns. A recent pilot project to improve the storage of guns conducted in southwest Alaska increased the proportion of households having all guns locked from 15% to 85%. The aims of this proposed study are to estimate the prevalence of firearm ownership and of specific firearm storage practices among residents living in the Bristol Bay and Yukon-Kuskokwim regions of southwest Alaska and to work with the Alaska Native health corporations to plan and execute a randomized trial of an intervention to improve firearm storage practices among residents of selected villages. This 3-year study consists of two phases.

The first phase is a regional survey of households within 20 randomly selected villages in southwest Alaska to estimate the extent of firearm ownership and existing storage practices in these communities. This weighted sample would be extrapolated to an overall estimate of these variables for each of the two Native corporations in the region. The second phase of the study will be a two-arm randomized controlled trial of an intervention to increase the proportion of households that store all of their firearms in a locked safe. A secondary outcome will be to reduce the proportion of home reporting the presence of a loaded gun. Households will be randomly assigned to either an early or late intervention group. The 'early' intervention group will receive the intervention at baseline. The 'late' intervention group will receive the intervention 12 months after baseline. All eligible households within participating villages will be educated about the potential protective value of safe firearm storage practices, and then be offered a gun safe to store all of their firearms. Household adults will be trained to use the safe and to carefully restrict access to the guns by youth. Each household will complete a questionnaire about storage practices and important co-variates at baseline, 12 months, and 18 months. Data will be analyzed to detect differences, between groups, in the proportion of homes with unlocked guns, and loaded guns, at 12 and 18 months after baseline. We estimate that the enrollment of 350 homes at baseline should provide 90% power to detect differences of about 16-20 absolute percentage point difference between groups, depending on the baseline prevalence of these variables. This study has the potential to have an important effect on firearm storage patterns in a population at high risk for suicide. If proven successful, it could be disseminated throughout Alaska and other high risk communities.
The invention discloses a traditional Chinese medicine composition, in particular a traditional Chinese medicine composition for treating breast hyperplasia and a preparation method of the composition. The traditional Chinese medicine composition is characterized by being made from: Bupleurum root, White Peony Root, selfheal, Cyperus rotundus, dried tangerine peel, radix curcumae, radix ranunculi ternati, rhizoma bolbostemmae, Iphigenieae, oysters, kelp, seaweed, Scrophularia, Scutellaria, fried frankincense, fried myrrh, the root of red-rooted salvia, Ligusticum wallichii, safflower and angelica. The traditional Chinese medicine composition is specially used for treating breast hyperplasia, a plurality of medicines are matched properly. With the mutual coordination or resistance of the medicines, the curative effect is enhanced to adapt to the treatment requirement of complex diseases and reduce adverse reaction. The traditional Chinese medicine composition is prominent in curative effect, addresses both symptoms and root causes, safe and reliable and has good treating effect on breast hyperplasia. Used for 240 cases totally, the composition reaches 98% of total effective rate.