anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Administered 10 x 10\^8 iTregs/kg or best available dose using sirolimus/MMF as graft-versus-host disease (GVHD) prophylaxis. Immunosuppression will consist of a combination of sirolimus and mycophenolate mofetil (MMF). Sirolimus will be administered starting at day -3 with 8mg-12mg oral loading dose followed by single dose 4 mg/day. MMF will be administered starting on day -3 at a dose of 3 gram/day divided in 2 or 3 doses. Intravenous (IV) route between days -3 and +5, then may change to PO between days +6 and +30. Stop MMF at day +30 or 7 days after engraftment, whichever day is later, if no acute GVHD.
Labouring women who have an epidural catheter in situ and established analgesia, in need of an unplanned Caesarean section, will be randomly allocated to receive either Chloroprocaine HCl 3% (T-group) or Ropivacaine HCl 0.75% (R-group) epidurally. Prior to the epidural injection, the patient will be transferred to the operating theatre. The local anaesthetic solution will be freshly prepared and 20 mL will be administered by epidural injection, according to the standard hospital procedures, as detailed in the "Study Schedule" section below. Time T0 is defined as the start time of the first epidural injection of the investigational product. In case of pain or discomfort, a 6 mL epidural top-up of the same anaesthetic, i.e. Chloroprocaine HCl 3% in T-group and Ropivacaine HCl 0.75% in R-group, will be administered. The anaesthesiologist(s) administering the anaesthetic and collecting the data will be blinded with respect to the treatment given to each patient.
Disclosed is a ticagrelor monohydrate crystal form. There are two large endothermic peaks at 102±5°C and 136±5°C in the differential scanning calorimetry spectrum thereof, and the thermogravimetry spectrum displays the presence of one molecule of crystallization water. This crystal form has a good storage stability, and the water-solubility thereof is better than the anhydrous crystal form reported. The ticagrelor monohydrate is obtained by heating and dissolving ticagrelor in a mixed solvent of an organic solvent and water, then cooling, crystallizing, filtering, and drying it. The preparation method is easy to operate, the solvent thereof is environmentally friendly and controllable and thus is easy to recycle and reuse, therefore the method is suitable for industrial mass production. The ticagrelor monohydrate can be used for preparing drugs for treating/preventing thrombosis.
Employment is important for financial security, social connection, and life satisfaction. Unfortunately, rates of unemployment remain high among people with spinal cord injury (SCI). To help address this challenge, the Northern New Jersey Spinal Cord Injury System (NNJSCIS) is conducting a single-site, randomized, controlled trial to compare two programs intended to increase rates of employment among people with SCI. The project will enroll 162 recently injured adults with SCI who are interested in becoming employed or returning to work and will compare different ways of delivering employment-related services in the first year after injury. Services will begin in inpatient rehabilitation and may include education, therapy, equipment provision, counseling, and other interventions. Information about employment status, earnings, community participation, and health will be collected through a combination of questionnaires and databases. Participants and service providers will also share their impressions of the programs via survey and focus groups. Analyses will examine the rate of participants employed at 1 year in each group, time to employment, earnings, community participation, and other aspects of well-being. Findings from this study will be used to determine which ways of delivering services are most effective in enabling employment by 1 year after injury, and to provide information to help other rehabilitation centers adopt effective programs.
The invention discloses a bionic anticarious polypeptide based on casein-rich saliva, a polypeptide derivative or a pharmaceutically acceptable salt thereof, and application thereof in pharmacy. The bionic anticarious functional polypeptide is based on an anticarious functional fragment of casein-rich saliva, and is subjected to amino acid sequence adjustment and improvement, and contains an amino acid sequence shown as SEQ ID NO. 1. The polypeptide is mainly combined with adsorption of demineralized enamel through the DpSEEK amino acid sequence, and the EEEEE amino acid sequence can act with calcium and phosphorus ions and induce hydroxyapatite nucleation, so that the in-situ mineralization repair effect on early enamel caries is realized. The polypeptide has the advantages of small molecular weight, convenient synthesis, low cost, good caries prevention effect, stable structure, safety and reliability. The invention designs the anti-caries polypeptide with the remineralization function by simulating the natural salivary protein by means of the bionic thought, and provides an ideal new way for preventing and treating caries.
All patients in the control group will receive routine diabetes management, including lifestyle education, health guidance, blood glucose monitoring and medicine adjustment and other treatments which conducted by the endocrinology medical team. After the inclusion visit, the patients will be randomized to Shared Care group or traditional therapy group. Compared to conventional diabetes education in the traditional therapy group, the Shared Care group provides patients with online services and continuous diabetes management and education through a mobile application. It also addresses that it is important for patients to meet regularly with diabetes multidisciplinary team for better results. The total observation period is 3 years for each patient. The visits will be done every 3 months.
Transposable elements (TEs) are mobile genetic modules of viral derivation that have been co-opted to become modulators of mammalian gene expression. TEs are a major source of endogenous dsRNAs, signaling molecules able to coordinate inflammatory responses in various physiological processes. Here, we provide evidence for a positive involvement of TEs in inflammation-driven bone repair and mineralization. In newly fractured mice bone, we observed an early transient upregulation of repeats occurring concurrently with the initiation of the inflammatory stage. In human bone biopsies, analysis revealed a significant correlation between repeats expression, mechanical stress and bone mineral density. We investigated a potential link between LINE-1 (L1) expression and bone mineralization by delivering a synthetic L1 RNA to osteoporotic patient-derived mesenchymal stem cells and observed a dsRNA-triggered protein kinase (PKR)-mediated stress response that led to strongly increased mineralization. This response was associated with a strong and transient inflammation, accompanied by a global translation attenuation induced by eIF2α phosphorylation. We demonstrated that L1 transfection reshaped the secretory profile of osteoblasts, triggering a paracrine activity that stimulated the mineralization of recipient cells.
<P>PROBLEM TO BE SOLVED: To provide a means usable in cleanly healing a wound so as not to leave an excoriation.  <P>SOLUTION: A mesenchymal cell is derived from a mammal and has a wound healing ability. The mesenchymal cell is obtained from mammalian bone marrow, menstrual blood or umbilical cord blood and has the wound healing ability. The mammal can be a rat, a pig or a human. A method for preparing the mesenchymal cell having the wound healing ability for transplantation into the wound of a patient comprises isolating the mesenchymal cell having the wound healing ability from the bone marrow, menstrual blood or umbilical cord blood of the patient having the wound and culturing the isolated cell. A method for treating the wound comprises transplanting an effective amount of the mesenchymal cell having the wound healing ability to the wound of the patient. A wound treating agent comprises the mesenchymal cell having the wound healing ability as an active ingredient.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
PURPOSE: To continuously prepare protein encapsulated microspheres by subjecting a heated protein soln. contg. gas to sonication to foam the soln., then forming gaseous microbubbles while insolubilizing the protein in the soln. by heating. CONSTITUTION: A biocompatible gas is passed into the segment of the dilute aq. soln. of heat-denaturatable water-soluble biocompatible protein before, during or after heating of this aq. soln. and is carried to the segment. The heated segment of the protein soln. contg. the gas is continuously fed to a chamber enclosing an operative sonication apparatus disposed with a sonication device horn, where the segment is subjected to the sonication to foam the soln. While the protein in the soln. is subjected to the insolubilization treatment by heating, the gaseous microbubbles are formed. The microspheres encapsulated with the stable protein are continuously formed in the segment of the soln. passing the chamber.
Subjects will be instrumented with a nasal cannula to receive 2L/min supplemental oxygen. The oxygen will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.
Disclosed are compositions and methods that can be used for the prevention, mitigation, and/or prophylactic treatment of a viral infection, such but not limited to a coronavirus infection, such as but not limited to a COVID-19 infection. In some embodiments, a chemically modified tetracycline (CMT) derivative for the prevention, mitigation and/or prophylactic treatment of a viral infection is provided. In some embodiments, the CMT derivative lacks anti-microbial activity; comprises a phenol ring; and/or comprises a chemical structure sufficient to chelate and/or bind a divalent cation. In some embodiments, the divalent cation comprises Zn2+. In some embodiments, the viral infection is a coronavirus infection. In some embodiments, the viral infection is a COVID-19 infection.
Self-Monitoring Blood Glucose will be managed with a traditional glucometer according to usual care for the first 6 months (experimental phase). In the 6 months post-trial follow-up (observational phase), Self-Monitoring Blood Glucose will be managed with iBGStar and iBGStar Diabetes Manager App.
Post-operative pain not only alleviates patient discomfort, but also delays recovery and thus prolongs the hospital stay. There are many ways to control postoperative pain, but analgesic infusion through venous route, patient controlled analgesia (PCA), especially narcotic analgesics, is often used to control the infusion when needed. However, because PCA is based on only age, weight, and underlying diseases, there are limitations in effective analgesia, and excessive sedation due to excessive infusion. Therefore, if the individual patient's pain is assessed and the amount of analgesic needed after surgery is predicted, appropriate injection of pain control and excessive injection of narcotic analgesic can be prevented. The noxious stimuli during surgery may have a negative effect on the healing process and surgical outcome of the wound due to stress reaction and catabolism, secretion of pituitary hormone, activation of the sympathetic nervous system, and immunological changes. Therefore, proper analgesia is needed during general anesthesia. A non-invasive, non-invasive analgesic device is currently available for Surgical pleth index (SPI) to assess the status of intraoperative analgesia. SPI = 100- (0.3 \* heart beat interval + 0.7 \* photoplethysmographic pulse wave amplitude) is automatically and continuously calculated from the waveform of peripheral oxygen saturation.

In the postoperative pain prediction study with SPI, the SPI value at the end of the operation was found to be proportional to the pain in the recovery room. However, only the pain score immediately after the operation was confirmed in these studies. Therefore, investigators try to evaluate the degree of pain during surgery and the amount of analgesic use for management of postoperative pain.
The invention discloses a liver-nourishing kidney-tonifying traditional Chinese medicine composition for treating liver cirrhosis. The liver-nourishing kidney-tonifying traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 4-6 parts of coptis chinensis, 12-16 parts of rhizoma atractylodis, 7-16 parts of flos rosae rugosae, 6-12 parts of yerbadetajo herb, 12-18 parts of fructus gardeniae, 5-8 parts of cortex acanthopanacis, 11-16 parts of cassia twig, 13-18 parts of polyporus umbellatus, 7-13 parts of fortunella hindsii, 11-18 parts of radix paeoniae rubra, 9-16 parts of ludwigia octoualuis(Jacq.)Raven, 7-15 parts of mulberry fruit, 12-17 parts of radix sophorae flavescentis, and 8-15 parts of fructus rubi. Effective ingredients of various dosage forms are stable, are safe, and have no toxic or side effects. According to the theory of traditional Chinese medicine, reasonable composition is achieved, and the liver-nourishing and kidney-tonifying traditional Chinese medicine composition is prepared from purely nature plant materials. The prepared liver-nourishing kidney-tonifying traditional Chinese medicine composition is remarkable in treatment effect, and short in course of treatment, and can promote liver function recovery of a patient.
The present invention is a peptide having from 5 to 20 amino acid residues having tumor cell invasion-inhibiting activities. As such a peptide, a peptide represented by any one of the formulas (1) to (13) is preferred among peptides. Further, the present invention is a cancer metastasis inhibitor comprising the above peptide as an active ingredient. Furthermore, the present invention is a peptide complex having a peptide having tumor cell invasion-inhibiting activities and a polymer derived from a vital body chemically bonded to each other. As such a peptide, a peptide represented by any one of the formulas (1) to (14) is preferred among peptides. As the polymer derived from a vital body, a protein such as albumin or globulin is preferred. Still further, the present invention is a cancer metastasis inhibitor comprising the above peptide complex as an active ingredient.
Sepsis is a systemic inflammatory reaction caused by infection, and severe sepsis can develop into septic shock, eventually leading to multiorgan dysfunction and even death. In recent years, studies have shown that mitochondrial damage is closely related to the occurrence and development of sepsis. Recent years have seen a surge in concern over mitochondrial DNA (mtDNA), as anomalies in this material can lead to cellular dysfunction, disruption of aerobic respiration, and even death of the cell. In this review, we discuss the latest findings on the mechanisms of mitochondrial damage and the molecular mechanisms controlling mitochondrial mtDNA release. We also explored the connection between mtDNA misplacement and inflammatory activation. Additionally, we propose potential therapeutic targets of mtDNA for sepsis treatment.
Methods and compositions for blocking calcium channels with a spider toxin Phoneutria nigriventer are provided. For easy identification the toxin will be sometimes generally referred to as Ph.alpha.-1B during the present description of the invention. The toxin comprises a 55-amino acid toxin having a molecular weight of approximately 6,017. This Ph.alpha.-1B spider toxin was found to block calcium channels within the nervous system. The synthetic gene responsible for producing this toxin has been designed and cloned. This gene and/or its derivative provide a mechanism by which the toxin can be produced using recombinant DNA expression technologies. The present invention further relates to methods of treating neurological diseases and pain by applying the isolated and identified toxins. The toxin Ph.alpha.-1B may provide beneficial effects on pain and certain neurological conditions including seizures, ischemic- hypoxic, CNS damage, and neurodegenerative disorders. It was also found that the toxins are effective as tags in probing calcium channels.
NNK, formally known as 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanoe, is a potent chemical carcinogen prevalent in cigarette smoke and is a key contributor to the development of human lung adenocarcinomas. On the other hand, autophagy plays a complex role in cancer development, acting as a "double-edged sword" whose impact varies depending on the cancer type and stage. Despite this, the relationship between autophagy and NNK-induced lung carcinogenesis remains largely unexplored. Our current study uncovers a marked reduction in p62 protein expression in both lung adenocarcinomas and lung tissues of mice exposed to cigarette smoke. Interestingly, this reduction appears to be contingent upon the activity of extrahepatic cytochrome P450 (CYP450), revealing that NNK metabolic activation by CYP450 enzyme escalates its potential to induce p62 downregulation. Further mechanistic investigations reveal that NNK suppresses autophagy by accelerating the degradation of p62 mRNA, thereby promoting the malignant transformation of human bronchial epithelial cells. This degradation process is facilitated by the hypermethylation of the Human antigen R (HuR) promoter, resulting in the transcriptional repression of HuR - a key regulator responsible for stabilizing p62 mRNA through direct binding. This hypermethylation is triggered by the activation of ribosomal protein S6, which is influenced by NNK exposure and subsequently amplifies the translation of DNA methyltransferase 3 alpha (DNMT3a). These findings provide crucial insights into the nature of p62 in both the development and potential treatment of tobacco-related lung cancer.
Oral doses of 240 mg/kg and 264 mg/kg in male and female mice, respectively, and 2390 mg/kg and 2250 mg/kg in male and female rats, respectively, caused significant lethality.

In a suicide attempt, one patient took 150 mg felodipine together with 15 tablets each of atenolol and spironolactone and 20 tablets of nitrazepam. The patient's blood pressure and heart rate were normal on admission to hospital; he subsequently recovered without significant sequelae.

Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly bradycardia.

If severe hypotension occurs, symptomatic treatment should be instituted. The patient should be placed supine with the legs elevated. The administration of intravenous fluids may be useful to treat hypotension due to overdosage with calcium antagonists. In case of accompanying bradycardia, atropine (0.5-1 mg) should be administered intravenously. Sympathomimetic drugs may also be given if the physician feels they are warranted.

It has not been established whether felodipine can be removed from the circulation by hemodialysis.

To obtain up-to-date information about the treatment of overdose, consult your Regional Poison-Control Center. Telephone numbers of certified poison-control centers are listed in the Physicians' Desk Reference (PDR). In managing overdose, consider the possibilities of multiple-drug overdoses, drug-drug interactions, and unusual drug kinetics in your patient.
OBJECTIVES: The study aimed to evaluate the correlation between self-reported pubertal developmental scale (PDS) and physically assessed Tanner staging by an experienced pediatrician among girls.
METHODS: In a school population-based study in Zhongshan, China, we recruited 1,722 girls in grades 1-3 by a multistage stratified cluster random sampling method. Participants completed self-reported PDS questionnaire prior to physical examination. Breast development was evaluated by a female pediatrician combined with ultrasound examination for overweight/obese girls; pubic hair development was evaluated. Otherwise, we tested follicle-stimulating hormone (FSH) and luteinizing hormone (LH) for some participants.
RESULTS: We observed a weak association between Tanner-derived composite stage (TDCS) and puberty category scores (PCS) (τ=0.288, p<0.001) among all girls. There was correlation (τ=0.314, p=0.001) between ultrasound-derived composite stage (UDCS) and PCS among overweight/obese girls. Moreover, among overweight/obese girls, PCS was positively correlated with LH (r=0.265, p=0.008), but not FSH (r=0.155, p=0.123), and when the basal LH value was greater than 0.3 mIU/mL, the proportion of PCS stage ≥2 (9/18) was higher than the proportion of TDCS ≥2 (5/18). As for the determination of pubertal onset, when UDCS was used as the gold standard, the specificity of PCS was 0.86 and positive predictive value was 90.00 %.
CONCLUSIONS: There was a weak correlation between PCS and TDCS among girls early adolescence. Moreover, among overweight/obese girls, combining hormone values, ultrasonographic stage of breast, and the positive predictive value of PCS, we posit that self-reported PDS might be a more reliable method than TDCS to evaluate pubertal development among overweight/obese girls.
The invention discloses a traditional Chinese medicine composition for preventing and treating poultry infectious laryngotracheitis and a preparation method thereof, and belongs to the technical field of veterinary traditional Chinese medicine. The traditional Chinese medicine is mainly composed of the following traditional Chinese herbals in parts by weight: 30 to 40 parts of radix scutellariae, 30 to 40 parts of isatis root, 20 to 30 parts of balloonflower root, 20 to 30 parts of rhizoma belamcandae, 10 to 25 parts of dwarf lilyturf tuber, 10 to 25 parts of fructus arctii, and 5 to 10 parts of licorice. The traditional Chinese herbals are compounded according to the principle of "monarch, minister, assistant and guide" in the traditional Chinese medicine theory. The radix scutellariae and isatis root have the functions of clearing heat, removing toxicity, and preventing pathogenic microorganisms and are taken as the monarch drugs; the balloonflower root and rhizoma belamcandae have the functions of relieving coughing, reducing phlegm, clearing heat, and moistening the lung, and are taken as the minister drugs; fructus arctii and dwarf lilyturf tuber have the functions of nourishing yin, engendering liquid, diffusing the lung, and soothing the throat, and are taken as the assistant drugs; and licorice has the functions of clearing heat, removing toxicity, and harmonizing the drugs and is taken as the guide drug. The traditional Chinese herbals mentioned above are co-used to generate the functions of clearing heat, removing toxicity, reducing phlegm, calming panting, boosting qi, and invigorating the spleen. The traditional Chinese medicine is mainly used to prevent and treat poultry infectious laryngotracheitis, and has the advantages of rapid effect, definite curative effect, pure traditional Chinese herbals, easily-available raw material, low price, safety, and no residue.
The patients included in this study are adult patients with a bilateral conductive or mixed hearing loss, that are already bilaterally implanted with two percutaneous bone-anchored devices (BAHS). The study consists of two visits. At visit 1, the patients are fitted unilaterally and bilaterally with the investigational device (Ponto 3 SuperPower). After fitting, the patients perform a test of spatial resolution (minimum audible angle, visit 1) and an auditory working memory test (visit 2). These two outcome measures are conducted in the laboratory using the Ponto 3 SuperPower unilaterally and bilaterally. Additionally, the patients fill in a questionnaire (SSQ12) to report perceived performance in their everyday life with their own devices. This is a post market study and all products used are CE marked and used in clinical practice worldwide.