anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Rectal cancer surgery risks causing bowel dysfunction, which has an important impact on health-related quality of life. The validity of generic tools used to measure health-related quality of life after bowel dysfunction is unclear. This study aimed to determine the content validity of health-related quality-of-life measurement tools in rectal cancer.
METHODS: This was a qualitative single-center study in which adult patients who underwent rectal cancer surgery with sphincter preservation from July 2017 to October 2020 were recruited. Patients were excluded if they developed local metastasis, required a permanent stoma, or had surgery <1 year since recruitment. Telephone-based semi-structured interviews were conducted. Bowel dysfunction was measured using the Low Anterior Resection Syndrome score. Content analysis was achieved using the International Classification of Functioning framework.
RESULTS: Recurrent bowel dysfunction-related concepts included "Mental functions," "Defecation functions," "Emotional functions," "Recreation and leisure," "Intimate relationships," and "Remunerative employment." A mean of 7.5 recurrent bowel dysfunction-related concepts were identified within the health-related quality of life instruments analyzed. The European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire-C30 (n = 11) and the 36-Item Short Form Health Survey (n = 9) covered the greatest number of recurrent bowel dysfunction-related concepts. Concepts such as "Mental functions," "Urination functions," "Sexual functions," "Driving," and "Mobility" were not covered by any instrument.
CONCLUSION: The content of traditional health-related quality-of-life instruments is missing important areas that represent the impact of bowel dysfunction after rectal cancer surgery on health-related quality of life. These findings could help improve patient-centered care in rectal cancer surgery.
PROBLEM TO BE SOLVED: To obtain an antioxidant which inhibits oxidation of e.g. fat and oil and an active oxygen eliminator having a possible effect of preventing various disturbances of a living body by using a benzophenone derivative. SOLUTION: The benzophenone derivative means a compound derived by replacing a hydrogen atom or hydrogen atoms of the benzene nuclei of a benzophenone skeleton by e.g. hydroxyls, carbonyls or hydrocarbon chains such as isoprenyl groups. It may be water-soluble or fat-soluble and may be one prepared by chemical synthesis or one obtained by extracting the contained benzophenone derivative from a plant. Examples of the former include polyisoprenylated benzophenone derivatives such as garcinol and isogarcinol. Examples of plants containing the latter benzophenone derivatives include plants belonging to the family Hypericaceae (e.g. Garcinia cambogia).
LCHF diet for 3 weeks, where E% 70 fat, E% 20-25 proteins and 20g or less carbohydrates. Oral glucose tolerance test on the morning of day 21 followed by a bout of exercise in the afternoon (indoor bicycle, 60min at 75% HFpeak). The following morning (day 22) a new oral glucose tolerance test. Oral glucose tolerance test results from pre-tests used to determine the effect of LCHF and a bout of exercise on insulin sensitivity.
PHASE 1) LaparoGuard will be used as an adjunctive tool for maintaining safety during procedures performed by expert surgeons. The pre-operative instructions for use will be evaluated along with ease of procedural setup, as reported by pre-operative nurses. The intraoperative instructions for use will be evaluated along with system usability, as reported by the expert surgeons. The perceived clinical utility will be judged by expert surgeons. Postoperatively, the system data will be reviewed. This phase will include 4-6 subjects.

PHASE 2) Novice surgeons will conduct procedures alongside expert surgeons. Expert surgeons will establish the safe zone. LaparoGuard will record all deviations, speed and smoothness of tip movements. The training utility of LaparoGuard will be assessed by both the expert and novice surgeons. This phase will include 4-6 subjects.
PCT No. PCT/AT96/00105 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Jun. 12, 1996 PCT Pub. No. WO96/41868 PCT Pub. Date Dec. 27, 1996The invention relates to new prothrombin mutants or derivatives thereof which comprise one or more changes in their protein sequence as compared to natural protein, are either inactive or have an activity of approximately 10% at the most, preferably approximately 0.25% at the most, of the natural protein and which have a binding capacity relative to natural ligands (natural or synthetic anticoagulants) substantially corresponding to that of the natural protein. Furthermore, the use of mutated prothrombin mutants or derivatives, respectively, as pharmaceutical preparations is described.
BACKGROUND: Literature comparing different alternatives for pain control in the immediate postoperative period of pediatric acute appendicitis (PAA) is scarce.
MATERIALS AND METHODS: We prospectively compared the analgesic and emetogenic profile of intravenous ibuprofen and metamizole in the immediate postoperative period of PAA. For this purpose, we used a sample of patients operated on in 2021 in our center. Participants were recruited on arrival at the Emergency Department and histopathological confirmation of the diagnosis was obtained in all of them. Pain was evaluated every 8 hours after the surgery with validated visual analog scales ranging from 0 to 10 points. Repeated measures ANOVA was used to compare the evolution of pain in the 48 hours after surgery between the two groups.
RESULTS: The sample included 95 patients (65% males) with a mean age of 9.7 years (sd: 3.14). 41 patients were treated with Ibuprofen (group 1) and 54 with metamizole (group 2). No significant differences were found in the level of pain either in the comparisons of point measurements or in its evolution in the 48 hours after surgery (p= 0.58). After adjusting for the received fluid therapy, children in the metamizole group had significantly more emetic episodes and needed significantly more doses of ondansetron.
CONCLUSIONS: In our cohort, ibuprofen had a similar analgesic efficacy and a better emetogenic profile than metamizole in the immediate postoperative period of PAA. Future prospective, adequately controlled studies with larger sample sizes are needed to validate these findings.
PURPOSE: To obtain a base material for powdering obtained by adding soluble starch and a polyol to an aqueous solution of a specific decomposition product of starch and drying the mixture, and capable of powdering an oily material and giving fluidity to the oily material by only mixing it with the oily material and leading to a composition having a low viscosity, rapidly soluble in cold-hot water and excellent in transparent feeling. CONSTITUTION: This base material for powdering is produced by adding soluble starch and/or a polyol to an aqueous solution of a starch decomposition product having 5-15 dextrose equivalent(DE) and drying by a drum dryer and has >=50wt.% of 32-145 mesh portion based on the total weight. The addition amount of the soluble starch is 10-100wt.% and that of the polyol is 0.5-10wt.% based on the starch decomposition product. Glycerol is used as the polyol. The decomposition product of starch is that of potato starch, tapioca starch, corn starch, etc. As the soluble starch, various starch or derivatives thereof produced by esterifying or etherealizing the starch, decomposing by using hydrochloric acid, etc., followed by drying the product and having 100-1000cp viscosity can be used. As the oily material, salad oil, palm oil, an agrochemical, a perfume, etc., are cited.
Retroviral vectors contain cis-acting viral elements for the expression, encapsidation, reverse transcription and integration of the retroviral genome nucleic acid sequence. However, these elements are not useful in the integrated provirus and may cause many problems. A retroviral vector is provided for eliminating most of the viral elements. This vector uses, among other things, the bacteriophage P1 Cre-lox recombination system. The 32-nucleotide loxP site is inserted into 3'LTR sequence U3 with the gene to be inserted into the cell. After loxP duplication using the LTR, the LTRs may be recombined by enzyme Cre. The structure of the resulting provirus in the host genome corresponds to a single LTR carrying a single copy of the gene to be inserted into the cell. If the Cre expression unit is inserted between the two LTRS, only single-LTR proviral structures are found following infection with the retroviral vector.
Biomimetic magnetic nanoparticles comprising MamC. The present invention provides magnetite comprising superparamagnetic biomimetic nanoparticles, which can be manufactured by a scalable process. Furthermore, these nanoparticles have promising properties, since, if functionalized, they can become drug transporters or contrast agents for clinical imaging. They can be used in clinical settings also to purge bone marrow as well as molecule separators and/or in environmental applications as biosensors. These nanoparticles, coupled with a drug, can be encapsulated in liposomes, obtaining magnetoliposomes, which can be functionalized for use in the targeted administration/release of drugs. In addition, mixtures of magnetoliposomes (both functionalized and non-functionalized with a targeting agent) and functionalized biomimetic magnetic nanoparticles or liposomes containing mixtures of functionalized BMNPs and MNPs can be used to combine different treatments such as targeted administration/release of drugs and hyperthermia. (Machine-translation by Google Translate, not legally binding)
Patients receive vincristine sulfate IV over 1-2 minutes and bleomycin sulfate IV over 10 minutes on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Batch de-identification of unstructured health care documents includes performing optical character recognition (OCR) upon a form-based document so as to produce an initial set of terms. Amongst the initial set of terms, initial specific terms are identified which contain protected information. Each of the identified initial specific terms are then replaced with synthetically generated corresponding terms. Subsequently, additional OCR is performed upon the form-based document so as to produce a new set of terms and new specific terms are identified amongst the new set of terms which are determined to contain protected information. Finally, the new specific terms are compared to the initial specific terms and the form-based document is then added to a repository of de-identified documents only if none of the new specific terms are equivalent to corresponding ones of the initial specific terms. But otherwise, the form-based document is flagged in error.
The mothers will receive passive temperature insulation by a cotton blanket (standard procedure) after start of the spinal anaesthesia for cesarean section. The newborn will be bonded on the mothers chest under the cotton blanket (also passive insulation without active warming) for 20 min after birth (bonding period).
Introduction: To analyze the influencing factors of ureteral stenosis after ureteroscopic holmium laser lithotripsy. Methods: The clinical data of 427 patients treated with ureteroscopic holmium laser lithotripsy were selected, and the patients were divided into two groups based on the presence or absence of ureteral stenosis after the operation. Univariate and multivariate logistic regression were used to analyze the independent risk factors for postoperative ureteral stenosis, and R software and regression coefficients were used to construct a predictive model. Results: After a 1-year follow-up of 427 patients, 28 patients (6.56%) developed ureteral stenosis; univariate analysis showed that the occurrence of ureteral stenosis after subureteral holmium laser lithotripsy was related to stone diameter, stone incarceration, degree of hydronephrosis, holmium laser injury of mucosa, and operation time (p < 0.05); further logistic regression analysis showed that a large stone diameter, stone incarceration, and moderate to severe hydronephrosis were independent risk factors for ureteral stenosis after ureteroscopic holmium laser lithotripsy (p < 0.05); According to H-L deviation degree and area under receiver operating characteristic curve test, the results show that the model has high accuracy (χ2 = 2.475, p = 0.613) and differentiation (0.875 [95% confidence interval or CI: 0.817-0.919]), and the external verification of the nomogram prediction model was carried out by the verification group. The results showed that the prediction probability of the calibration curve was close to the actual probability and had a good consistency (area under the curve: 0.873 [95 CI: 0.822-0.914]). Conclusion: The established nomogram model exhibits high accuracy and discriminative ability. It can effectively identify high-risk groups, enabling timely prevention of ureteral stenosis and minimizing the risk of postoperative ureteral stenosis.
Retinal vasculitis is a major component of ocular inflammation that plays a critical role in retinal tissue damage and subsequent vision loss. Retinal vasculitis can occur as a primary ocular disease or secondarily, as a component of a systemic vascular disease. Unfortunately, little is known about primary retinal vasculitis. The initiating event in retinal vasculitis is most likely multifactorial. Nevertheless, the underlying pathologic mechanisms driving this process may be common. We hypothesize that there are biological markers of retinal vasculitis, such as, cytokines, chemokines, adhesion molecules, T-cell surface markers and autoantibodies which can be useful in determining disease progression, understanding mechanisms of pathogenesis, identifying therapeutic strategies and monitoring treatments. The purpose or objective of this study is to investigate selected biological markers to collect clinical and biologic information to better understand the natural history of conditions indicative of primary retinal vasculitis.

The goal of this study is to evaluate patients with primary retinal vasculitis disorders. We will compare this group of patients with two additional types of uveitis patients with retinal vasculitis; patients with Behcet's syndrome and HIV patients undergoing HAART therapy with immune recovery uveitis. Patient evaluations will consist of the following procedures: a full ocular examination, fluorescent angiogram study, blood collection and therapy. Patient blood samples will be studied to evaluate the presence of three types of biological markers (1) cytokines, chemokines or adhesion molecules, (2) autoantibodies and (3) infectious agents. The primary outcome of this study is the identification of biological markers in patients with retinal vasculitis.
This randomized controlled trial of oral curcumin for the treatment of pain of CMC arthritis will investigate the therapeutic potential of curcumin as an oral treatment for pain of CMC arthritis. Rationale: Curcumin is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for knee osteoarthritis, however no clinical trial has been performed to establish efficacy of curcumin in humans for CMC arthritis. Hypothesis: Curcumin is more effective than placebo for relieving pain and improving patient-reported outcomes for CMC arthritis Study Design: The study design will be a double-blind, randomized controlled trial with crossover. Treatment will be blinded to the subjects and investigators. Patients will be randomly assigned 4 weeks of the Curcumin or control and then crossover to the other condition for 4 additional weeks. Patients will take the oral curcumin or control placebo capsule twice daily. Subjects will be advised to observe adverse effects.

The study design will be a double-blind randomized control trial with crossover. Treatment will be blinded to the subjects and investigators. Patients will be randomly assigned 4 weeks of the case (curcumin) or control capsules and then crossover to the other condition for 4 more weeks with a 2-week washout interval between. Patients will take one oral capsule by mouth twice daily. The subjects will be advised to observe for physiologic changes, skin changes, or other adverse effects. If mild to severe adverse events are noticed, the patient's will discontinue the use of the capsules, and appropriate care and observation will be taken. Each condition will last for 4 weeks and then subjects will be contacted by the study coordinator to facilitate crossover into the other condition following a 2-week washout period. To capture any delayed-onset adverse events, subjects will attend a follow-up visit seven days following the last dose of the curcumin capsule.
Aqueous solution (A) containing opipramol (I) as a salt, and suitable for pharmaceutical processing also includes at least one sweetening agent (II), i.e. a mono- or di-saccharide alcohol or a synthetic sweetener. An independent claim is also included for an aqueous solution containing opipramol (I) as a salt also at least one sweetening agent (II), and suitable for pharmaceutical processing, that has a lower tendency to discolor than the corresponding solution without (II), where color is measured by the CIE-Lab system. ACTIVITY : Antidepressant. No details of tests for antidepressant activity are given. MECHANISM OF ACTION : None given.
BACKGROUND: There is an ongoing controversy regarding whether single-occupancy rooms are superior to multiple-occupancy rooms in terms of infection prevention. We investigated whether treatment in a multiple-occupancy room is associated with an increased incidence of nosocomial coronavirus disease 2019 (COVID-19) compared with treatment in a single-occupancy room.
METHODS: In this retrospective cohort study, every hospitalization period of adult patients aged ≥ 18 years at a tertiary hospital in Korea from January 1, 2022, to December 31, 2022, was analyzed. If COVID-19 was diagnosed more than 5 days after hospitalization, the case was classified as nosocomial. We estimated the association between the number of patients per room and the risk of nosocomial COVID-19 using a Cox proportional hazards regression model.
RESULTS: In total, 25,143 hospitalizations per room type were analyzed. The incidence rate of nosocomial COVID-19 increased according to the number of patients per room; it ranged from 3.05 to 38.64 cases per 10,000 patient-days between single- and 6-bed rooms, respectively. Additionally, the hazard ratios of nosocomial COVID-19 showed an increasing trend according to the number of patients per room, ranging from 0.14 (95% confidence interval 0.001-1.03) to 2.66 (95% confidence interval 1.60-4.85) between single- and 6-bed rooms, respectively.
CONCLUSIONS: We demonstrated that the incidence of nosocomial COVID-19 increased according to the number of patients per room. To reduce nosocomial infections by respiratory viruses, the use of multiple-occupancy rooms should be minimized.
An anti-infectant preparation for medicinal use comprises at least one reducing agent having a chain of not more than six carbon atoms and an enediol group, a nongaseous oxidizing agent capable of oxidizing the enediol group in aqueous medium, and a substance capable of yielding ions of at least one of the metals, copper, iron, manganese, nickel, cobalt or zinc, as a catalyst for the oxidation, any aqueous phase present contacting one only of the enediol and oxidizing constituents prior to use.  Peroxides, e.g. hydrogen or carbamide peroxide, or alkali metal percarbonates or perborates are the preferred oxidizing agents and may be present in substantially equimolar proportion to the enediol compound.  Enediol compounds specified are ascorbic, reductic and dihydroxy-maleic or dihydroxy-fumaric acids, reductane and water-soluble salts or derivatives e.g. esters, thereof.  The catalyst, which preferably yields copper ions, is present in a proportion of from 0.00003 to 0.01 mol of copper per mol of enediol compound, or from 0.000004 to 0.0004 per cent by weight of the preparation.  The oxidizing and reducing agents are kept separately and the preparation kept free from moisture e.g. in water-free vehicles such as paraffin, olive oil or glycerol, and are not brought together in the presence of water until the time of application.  The preparation may be preserved in the form of water-free powders, tablets or ampull  by granulating the reaction mixture and coating the particles with sodium silicate, or in the form of water-free pastes made up with glycerol.  The final pH of the preparation, between 5 and 8, may be obtained by addition of sodium hydroxide or carbonate, or citric acid, either after the hydration of the water-free preparation, or to each component prior to mixing.
An eyeshade for clearing away heart-fire and improving eyesight relates to eye nursing and eye health care products. Aiming at the problems of eye fatigue, eye dryness, itching, eye wrinkles, eye bags, dark circles, similar eyes, presbyopia and the like caused by excessive use of eyes, the eye mask for clearing away the heart fire and improving the eyesight, which is polluted by traditional Chinese medicines, acupuncture point stimulation, eye health care, light, sound and electric waves isolation, is provided. Has the effects of shading light, insulating sound, preventing radiation pollution, clearing away the heart fire, activating collaterals, relieving swelling and pain, improving eyesight, soothing nerves and caring eye health. Can relieve temporary ametropia such as myopia, hypermetropia, astigmatism and the like caused by long-time tension of eyes. Effectively prevent diseases caused by work and study pressure and eye discomfort. Has the characteristics of novel concept, unique process, convenient use and obvious effect. Is very suitable for people who often face electronic products such as televisions, computers, mobile phones and the like.
The invention relates to a Chinese material medicine preparation for treating eczema. The Chinese material medicine preparation is prepared from the following raw medicines: 12 g of Chinese angelica, 15 g of white peony roots, 10 g of radix gentianae, 15 g of common selfheal fruit-spikes, 10 g of plantain seed, 10 g of atractylodes rhizomes, 12 g of bighead atractylodes rhizomes, 15 g of poria cocos, 15 g of tree peony bark, 20 g of honeysuckle, 10 g of forsythia suspensa, 15 g of lithospermum, 15 g of herba violae, 12 g of prepared rehmannia roots, 10 g of asiatic cornelian cherry fruits, and 6 g of licorice roots. For a patient with poor appetite, 15 g of haw and 10 g of radish seed are added; for a patient with dry stool, 10 g of raw rhubarb and 6 g of mirabilite are added; for a patient with heat and yellow coated tongue, 10 g of phellodendron and 12 g of talc are added; for a patient with fantod mood and poor sleep, 12 g of arborvitae seed and 12 g of albizia flowers are added. The Chinese material medicine preparation is prepared by the following steps: taking the raw medicines, adding 1000 ml of water, soaking the taken raw medicines in the water for 30 minutes, cooking the soaked raw medicines with mild fire until 200 ml of liquid medicine is remained, and filtering off dregs so as to prepare a decoction. The decoction is taken twice in the morning and at night. The Chinese material medicine preparation disclosed by the invention is prepared from pure traditional Chinese medicines, is good in curative effect, takes effect quickly, and has small toxic and side effect.