anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Objective: To comprehensively understand the disease burden of liver cirrhosis and other chronic liver diseases caused by alcohol use in China from 1990 to 2019, as well as to predict the trends in disease burden from 2020 to 2030. Methods: The analysis utilized data from the Global Burden of Disease study in 2019 (GBD2019). Key indicators such as incidence rate, mortality rate, disability-adjusted life years (DALY), years of life lost due to premature mortality, and years lived with disability were selected to describe the disease burden of alcohol-related liver cirrhosis and other chronic liver diseases in China from 1990 to 2019. The estimated annual percentage change (EAPC) was used to depict the temporal trends in disease burden. Furthermore, a Bayesian age-period-cohort (BAPC) model was constructed using R software to predict the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of alcohol-related liver cirrhosis and other chronic liver diseases in China from 2020 to 2030. Results: From 1990 to 2019, the incidence of alcohol-related liver cirrhosis and other chronic liver diseases in China showed an upward trend, with an EAPC of 0.31% (95%CI: 0.10%-0.52%). However, the DALY declined, with an EAPC of -2.81% (95%CI: -2.92% - -2.70%). The ASMR showed a downward trend, with an EAPC of -2.55% (95%CI: -2.66% - -2.45%). The highest incidence of cirrhosis of liver caused by alcohol and other chronic liver diseases was reported in the age group of 35-49 years, while the ASMR increased gradually with age, with a significant rise after the age of 30. The age-standardized DALY rate peaked between the ages of 55 and 64. The disease burden indicators for males were consistently higher than those for females during the same period. According to the predictions of the BAPC model, from 2020 to 2030, the ASIR for cirrhosis of liver caused by alcohol and other chronic liver diseases in the entire population of China was projected to increase from 3.45/100 000 in 2020 to 3.78/100 000 in 2030, a growth of 9.57%. Conversely, the ASMR was expected to decrease from 1.45/100 000 in 2020 to 1.24/100 000 in 2030, a reduction of 14.48%. Conclusions: The disease burden of cirrhosis of liver caused by alcohol and other chronic liver diseases remained serious in China, especially in men and the middle-aged to elderly population. There is a pressing need to prioritize attention and resources towards these groups. Despite the projected decrease in ASMR, the ASIR continued to rise and is expected to persist in its upward trend until 2030.
Participants will be randomized in one of three groups: HIIT, ST or ST combined with HIIT (ST+HIIT). Each training protocol will last 10 weeks, being the initial two weeks designed to participants' gradual adaptations to respective training protocol, with sessions performed three times per week in non-consecutive days.
Patients with ischemic cardiomyopathy (left ventricular ejection fraction \<35%) and heart failure who already have an implantable device with an atrial lead (dual chamber defibrillator or biventricular defibrillator) will undergo sequentially 1. Sham LLTS (5min), 2. Active LLTS at 5Hz (15min) and 20Hz (15min) and 3. Active LLTS group with atrial pacing at 100bpm at 5Hz (15min) and 20Hz (15min).
The present disclosure is drawn to a disinfectant system which can be used to disinfect surfaces. The system includes a first chamber containing a first solution and a second chamber containing a second solution. The first solution can include an alcohol, an organic carboxylic acid, and from 0.01 ppm, to 1,000 ppm by weight of a transition metal or alloy thereof based on the first solution weight content. The second solution can include hydrogen peroxide. The system further includes a dispenser through which the system is configured to mix and dispense the first solution and the second solution immediately before being dispensed. A peracid composition is formed upon mixing of the first and second solutions.
For this arm, participants will receive the ureteroscopy for their kidney and ureter stones using reusable fiberoptic flexible ureteroscope (URF-P6, Olympus). The surgical method of the ureteroscopy will be a standard fashion same as other arms.
INTRODUCTION: Use of indocyanine green (ICG) with near-infrared fluorescence (NIRF) has been demonstrated to be an effective tool for intraoperative assessment of bowel and ureteric vascularity. This study aimed to evaluate the impact of ICG on postsurgical outcomes such as anastomotic bowel leak and uretero-enteric stricture formation during robot-assisted cystectomy (RAC) and intracorporeal urinary diversion (ICUD).
METHODS: We identified 238 patients who underwent RAC at the University of Louisville between September 2012 and August 2021. Patients were divided into two groups based on the utilization of ICG. Demographic, perioperative outcomes, and rate of anastomotic bowel leak were compared.
RESULTS: In total, 138 patients were in the ICG group and 100 patients were in the non-ICG group. More intracorporeal urinary diversions and more simple cystectomies were observed in the ICG group (p < 0.001 and p = 0.015, respectively). The ICG group patients initiated an oral diet sooner than the control group (4.9 vs. 7.1 days, p < 0.001). The mean length of stay of the ICG group was shorter than the non-ICG group (8.3 vs. 12.8 days, p < 0.001). The rate of postoperative ileus was not significantly different between cohorts. No patients in the ICG group experienced a bowel leak compared with five patients in the non-ICG group (p = 0.008).
CONCLUSIONS: In our study, the use of ICG for intraoperative assessment of bowel and ureteric vascularity was associated with earlier bowel recovery and a shorter length of stay. It was also significantly correlated with a lower rate of anastomotic bowel leak.
These children will be recruited from district 8, Ho Chi Minh City where most HFMD admissions to the Hospital for Tropical Diseases occur. We wil recruit healthy children from three kindergartens and ask for volunteers from participants enrolled in an Oxford University Clinical Research Unit Dengue birth cohort study (OXTREC approval 02-09) in District 8, HCMC. This birth cohort is an observational study.
Solutions of enzymatic protein hydrolysates containing 3-20 g of hydrolysate comprising amino-acids per 100 c.c. of water are stabilized by incorporating, for each 100 c.c. of water, .02-1 g. of a protective colloid forming a clear solution in water and compatible with human blood.  Suitable enzymatic hydrolysates which are sufficiently pure for parenteral use include enzymatic digestates of casein, lactalbumin or beef serum protein.  High grade gelatines, pectins, and peptones are colloids specified. They are added to the aqueous solvent prior to, with or after the hydrolysate, and before or after bottling.  A solution of the hydrolysate may be formed, cooled, filtered to remove any precipitate, the colloid added, and the solution sterilized in sealed bottles.  Repeated sterilization may be effected after storage to redissolve any precipitate. Examples illustrate the effect of varying additions of gelatine, pectin or peptone to solutions of casein or lactalbumin hydrolysates.ALSO:Solutions of enzymatic protein hydrolysates containing 3-20g of hydrolysate comprising amino-acids per 100 c.c. of water are stabilized by incorporating, for each 100 c.c. of water, .02-1g. of a protective colloid forming a clear solution in water and compatible with human blood.  Suitable enzymatic hydrolysates which are sufficiently pure for parenteral use include enzymatic digestates of casein, lactalbumin or beef serum protein.  High grade gelatines, pectins, and peptones are colloids specified. They are added to the aqueous solvent prior to, with or after the hydrolysate, and before or after bottling.  A solution of the hydrolysate may be formed, cooled, filtered to remove any precipitate, the colloid added, and the solution sterilized in sealed bottles.  Repeated sterilization may be effected after storage to re-dissolve any precipitate. Examples illustrate the effect of varying additions of gelatine, pectin or peptone to solutions of casein or lactalbumin hydrolysates.
BACKGROUND: The Roux-en-Y gastric bypass (RYGB) is a common bariatric surgery to treat obesity. Its metabolic consequences are favourable and long-term clinical corollaries beneficial. However, detailed assessments of various affected metabolic pathways and their mediating physiological factors are scarce.
METHODS: We performed a clinical study with 30 RYGB patients in preoperative and 6-month postoperative visits. NMR metabolomics was applied to profiling of systemic metabolism via 80 molecular traits, representing core cardiometabolic pathways. Glucose, glycated haemoglobin (HbA1c), insulin, and apolipoprotein B-48 were measured with standard assays. Logistic regression models of the surgery effect were used for each metabolic measure and assessed individually for multiple mediating physiological factors.
RESULTS: Changes in insulin concentrations reflected those of BMI with robust decreases due to the surgery. Six months after the surgery, triglycerides, remnant cholesterol, and apolipoprotein B-100 were decreased -24%, -18%, and -14%, respectively. Lactate and glycoprotein acetyls, a systemic inflammation biomarker, decreased -16% and -9%, respectively. The concentrations of branched-chain (BCAA; leucine, isoleucine, and valine) and aromatic (phenylalanine and tyrosine) amino acids decreased after the surgery between -17% for tyrosine and -23% for leucine. Except for the most prominent metabolic changes observed for the BCAAs, all changes were almost completely mediated by weight change and insulin. Glucose and type 2 diabetes had clearly weaker effects on the metabolic changes.
CONCLUSIONS: The comprehensive metabolic analyses indicate that weight loss and improved insulin sensitivity during the 6 months after the RYGB surgery are the key physiological outcomes mediating the short-term advantageous metabolic effects of RYGB. The clinical study was registered at ClinicalTrials.gov as NCT01330251.
Efferocytosis, the clearance of apoptotic cells by macrophages, plays a crucial role in inflammatory responses and effectively prevents secondary necrosis. However, the mechanisms underlying efferocytosis in acute pancreatitis (AP) remain unclear. In this study, we demonstrated the presence of efferocytosis in injured human and mouse pancreatic tissues. We also observed significant upregulation of CD47, an efferocytosis-related the "do not eat me" molecule in injured acinar cells. Subsequently, we used CRISPR-Cas9 gene editing, anti-adeno-associated virus (AAV) gene modification, and anti-CD47 antibody to investigate the potential therapeutic role of AP. CD47 expression was negatively regulated by upstream miR133a, which is controlled by the transcription factor TRIM28. To further investigate the regulation of efferocytosis and reduction of pancreatic necrosis in AP, we used miR-133a-agomir and pancreas-specific AAV-shTRIM28 to modulate CD47 expression. Our findings confirmed that CD47-mediated efferocytosis is critical for preventing pancreatic necrosis and suggest that targeting the TRIM28-miR133a-CD47 axis is clinically relevant for the treatment of AP.
BACKGROUND: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) lead to severe irritation and impaired sperm quality in males. However, current therapeutic options often fail to achieve satisfactory effects. Consequently, the investigation of novel treatment strategies or remedies holds substantial clinical importance. As a flavonoid monomer, isoliquiritigenin (ISL) has been shown to possess anti-inflammatory activity, especially in several chronic nonspecific-inflammatory conditions. Thus, an exploration of the possible anti-inflammatory effects of ISL on CP/CPPS, a chronic aseptic inflammation of the prostate, has significant potential.
METHODS: An experimental autoimmune prostatitis (EAP) model was used for the evaluation of the anti-inflammatory effects of ISL. It was found that ISL treatment could reduce the secretion and invasion of pro-inflammatory cytokines in prostate tissue. In EAP mice, ISL treatment also reduced oxidative stress (OS) and activation of the NLRP3 inflammasome. In vitro, ISL upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and inhibited NLRP3 inflammasome activation in RAW264.7 macrophages exposed to lipopolysaccharide (LPS).
RESULTS: Treatment with ISL treatment relieved prostate inflammation and pelvic pain in EAP mice. Both in vivo and in vitro, ISL treatment activated Nrf2/HO-1 signaling, which in turn inhibited oxidative stress and activation of the NLRP3 inflammasome. Blockade of Nrf2/HO-1 signaling abolished the inhibitory effects of ISL on oxidative stress and NLRP3 inflammasome activation.
CONCLUSIONS: Isoliquiritigenin reduced experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) is the most common subset. We previously found that infiltration of tumor inflammatory monocytes (TIMs) into lung squamous carcinoma (LUSC) tumors is associated with increased metastases and poor survival. To further understand how TIMs promote metastases, we compared RNA-Seq profiles of TIMs from several LUSC metastatic models with inflammatory monocytes (IMs) of non-tumor-bearing controls. We identified Spon1 as upregulated in TIMs and found that Spon1 expression in LUSC tumors corresponded with poor survival and enrichment of collagen extracellular matrix signatures. We observed SPON1+ TIMs mediate their effects directly through LRP8 on NSCLC cells, which resulted in TGF-β1 activation and robust production of fibrillar collagens. Using several orthogonal approaches, we demonstrated that SPON1+ TIMs were sufficient to promote NSCLC metastases. Additionally, we found that Spon1 loss in the host, or Lrp8 loss in cancer cells, resulted in a significant decrease of both high-density collagen matrices and metastases. Finally, we confirmed the relevance of the SPON1/LRP8/TGF-β1 axis with collagen production and survival in patients with NSCLC. Taken together, our study describes how SPON1+ TIMs promote collagen remodeling and NSCLC metastases through an LRP8/TGF-β1 signaling axis.
An emulsifiable vitamin preparation comprises 25-95% by weight of a solution of a vitamin-active compound in an edible triglyceride oil, and 75-5% of an emulsifier composition (see Division B1) comprising 1.5 to 4 parts by weight of polyethylene sorbitan monooleate containing 20 equivalents of ethylene oxide and one part by weight of monoolein or a glycerin/safflower oil esterification product molecularly distilled to contain at least 90% of esters, the oil forming at least 5% of the preparation. The preparation may be made by mixing the components and may be emulsified by mixing with water. Examples are given of preparation of vitamin A palmitate, d-alpha-tocopheryl acetate (Vitamin E) and mixtures of vitamins A and D2 and of vitamins A, D2 and E, the oil being corn oil or cottonseed oil.  1 : 2-dihydroxy-6-ethoxy-2 : 2 : 4-trimethylquinoline is present in a vitamin A preparation as antioxidant.ALSO:An emulsifier composition, suitable for forming aqueous emulsions of vitamins in edible triglyceride oils (see Division A5), comprises 1.5-4 parts by weight of polyoxyethylene sorbitan monooleate containing 20 equivalents of ethylene oxide and 1 part by weight of monoolein or a glycerin/safflower oil esterification product molecularly distilled to contain at least 90% esters.  The esterification product contains glycerol monolinoleate, monooleate and saturated monoglycerides, the latter of which may be removed e.g. by dissolving the product in acetone, storing at -20 DEG C. filtering and removing the remaining acetone under vacuum ("wintering").  The emulsifiable vitamin preparation comprises 25-95% by weight of a solution of a vitamin-active compound in an edible triglyceride oil, and 75-5% of the emulsifier composition, the oil forming at least 5% of the preparation.  The preparation may be made by mixing the components and may be emulsified by mixing with water.  Examples are given of preparations of vitamin A palmitate, d-a -tocophenyl acetate (vitamin E) and mixtures of vitamins A and D2 and of vitamins A, D2 and E, the oil being corn oil or cotton seed oil. 1:2-dihydroxy-6-ethoxy-2:2:4-tri methylquinoline is present in a vitamin A preparation as antioxidant.
Distraction is a new treatment for trapeziometacarpal joint osteoarthritis. The purpose of this study was to test the efficiency of magnetic distraction using a new internal distractor in cadavers. The distractor consists of two magnets embedded inside titanium capsules that are implanted on either side of the trapeziometacarpal joint with the same poles facing each other, so that the force between the magnets distracts the joint. Intra-articular forces were recorded pre-implantation, immediately after implantation and again 10 minutes later. We also studied the changes in the forces before and after the procedure in different thumb positions. Our findings show that the trapeziometacarpal joint could be offloaded in all the studied trapeziometacarpal positions.
Immunophenotyping of blood lymphocyte subtypes can provide vital information for diagnosing and treating immunological nonresponse for people living with HIV (PLHIV). This study aimed to characterize lymphocyte subtypes among PLHIV with different immunologic responses. We recruited PLHIV from the Guangzhou Eighth People's Hospital in Guangzhou between 1 November to 31 December 2023. Participants were grouped into immunological responders (IR, CD4+ T cell count ≥ 500 cells/μL) and immunological non-responders (INR, < 350 cells/μL) after more than 4 years of antiretroviral therapy (ART). Flow cytometry was used to determine the profiles of peripheral blood lymphocyte subtypes. Spearman rank correlation analysis was conducted between lymphocyte subtypes and disease progression indicators. A total of 387 PLHIV were included, among whom 255 were INR and 132 IR. The number of total B and T lymphocytes, natural killer cells, natural killer T-like cells, and the percentage of naive helper T lymphocytes were decreased in INR group than those in IR. However, the percentages of memory helper T lymphocytes and suppressor T lymphocytes were more abundant in INR. Notably, we found that levels of the immune activation cells were higher in INR group, since the percentages of activated helper T lymphocytes and activated T lymphocytes were more abundant in INR. Lymphocyte subtypes had slight correlations with WBC, PLT, Scr and Glu. This study described the comprehensive immune cell profile of lymphocyte subtypes and provided clues for a deeper understanding of the mechanism of poor immunologic recovery in INR.
1,204,862. Water soluble polymers. PHARMACIA A.B. 1 Dec., 1967 [2 Dec., 1966], No. 54788/67. Heading C3B. [Also in Division A5] Linear or branched chain polymers have an average M.W. of at least 5000 and are built up of alternating groups of formula (or physiologically acceptable salts thereof) and intermediate straight or branched chain C 3-30  aliphatic hydroxyl containing bridges. The polymers are obtainable by reacting a 3,5- bifunctional 2,4,6-triiodobenzoic acid derivative with a bifunctional aliphatic bridge former, said bridge former containing or being capable of forming one or more OH groups as a result of the polymerization process. Examples of bridge formers are diepoxides, e.g. bis-(2,3-epoxypropyl) ether, 1,2-ethanediol diglycidyl ether, 1,4-butanediol diglycidyl ether or 1,3-glycerinediglycidyl ether. Examples of groups of Formula I are (R is an acyl group containing up to 5 carbon atoms). Examples of aliphatic bridges are: and The polymers may be used either in solution or in conjunction with a physiologically acceptable solid carrier as preparation for the X-ray visualization of body cavities.
The invention discloses application of Kangai injection as an attenuation synergist of an anti-PD-1 antibody of a liver cancer therapeutic drug. The invention provides application of PD-1 blocker and Kangai injection in preparing medicaments for treating liver cancer. The invention also protects the application of the Kangai injection in preparing the sensitizer; the sensitizer has the function of improving the sensitivity of liver cancer tumor tissues to PD-1 blockers. The invention also protects the application of the Kangai injection in preparing a synergist; the function of the synergist is to enhance the anti-liver cancer activity of the PD-1 blocker. The invention also protects the application of the Kangai injection in preparing the antidote; the function of the antidote is to reduce the cardiotoxicity and/or pulmonary toxicity of the PD-1 blocker to the organism. The invention develops a new liver cancer treatment strategy, improves the curative effect and the response rate of immunotherapy, can furthest improve the clinical benefit and greatly reduces the toxic effect to the minimum.
Serum 89SF is a pooled sera from individuals vaccinated with a 23 valent pneumococcal polysaccharide vaccine collected in the late 1980s. The 89SF standard for ELISA is running low (2-3 year supply) and is insufficient to serve for opsinophagocytosis assay (OPA), which requires large volumes. The objective of this study is to immunize healthy volunteers with licensed polyvalent pneumococcal polysaccharide vaccine (Pneumovax 23) with subsequent blood donation in a quantity sufficient to make reference sera. Two hundred fifty volunteer subjects will be recruited from a total population of up to 600. Study participants will include healthy men and nonpregnant females, ages 18-45. Subjects will undergo physical examination by a licensed clinician, subject interview, and clinical laboratory and serologic testing. Potential subjects must provide written informed consent and meet all eligibility criteria. On Day 0, subjects will receive 0.5 mL pneumococcal vaccine (Pneumovax 23) in the deltoid muscle. Volunteers will remain in the clinic for 30 minutes following immunization for observation of any adverse reactions. Volunteers will return to clinic in 10-35 days following immunization to donate 1 unit (approximately 500 mL) of blood. Volunteers will return for a second donation of 1 unit of blood not less than 8 weeks and not more than 14 weeks following the first donation.
Amatoxins are responsible for most fatal mushroom poisoning cases, as it causes both hepatotoxicity and nephrotoxicity. However, studies on amatoxin nephrotoxicity are limited. Here, we investigated nephrotoxicity over 4 days and nephrotoxicity/hepatotoxicity over 14 days in mice. The organ weight ratio, serological indices, and tissue histology results indicated that a nephrotoxicity mouse model was established with two stages: (1) no apparent effects within 24 h; and (2) the appearance of adverse effects, with gradual worsening within 2-14 days. For each stage, the kidney transcriptome revealed patterns of differential mRNA expression and significant pathway changes, and Western blot analysis verified the expression of key proteins. Amanitin-induced nephrotoxicity was directly related to RNA polymerase II because mRNA levels decreased, RNA polymerase II-related pathways were significantly enriched at the transcription level, and RNA polymerase II protein was degraded in the early poisoning stage. In the late stage, nephrotoxicity was more severe than hepatotoxicity. This is likely associated with inflammation because inflammation-related pathways were significantly enriched and NF-κB activation was increased in the kidney.