anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: organic chemistry, fungicides, medicine. SUBSTANCE: invention describes pharmaceutical and veterinary compositions comprising a carrier and an active substance as compound of the formula (I):   wherein R 1  and R 2  means independently of one another hydrogen, halogen atom or methoxy-group and salts of compound of the formula (I) also. Invention proposes also the application of the indicated formula (I) for preparing pharmaceutical or veterinary composition for treatment of fungal infections. Composition is effective for eradication of fungal infections, such as caused by dermatophytes and can be used for peroral, parenteral or topical application. The composition exhibits systemic effect also. EFFECT: valuable medicinal properties of composition. 8 cl
To analyze the factors associated with the overall patient condition and explore the clinical value of the Patient Global Assessment (PGA) index for assessing the disease state in patients with Ankylosing Spondylitis (AS). This cross-sectional study used a standardized questionnaire to record the basic information of patients with AS. The collected data included the Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (CRP), ASDAS-erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), PGA, and other clinical indicators. Statistical analysis was performed using SPSS 25.0 software, and the scale was assessed for retest reliability and structural validity. The Kruskal-Wallis H test and Spearman or Pearson correlation analysis were used to analyze the factors influencing PGA scores. The receiver operator characteristic (ROC) curve was used to identify the cutoff value of the PGA for predicting disease activity in AS. The patient age, disease duration, family history, and history of ocular inflammation significantly differed between PGA groups (P < .05). The median PGA was significantly lower in patients with disease remission than in those with disease activity (P < .01). The various clinical indexes significantly differed between PGA groups (P < .01). The PGA was significantly correlated with various clinical indicators (P < .01). The area under the ROC curve (AUC) for disease activity based on the ASDAS-CRP was 0.743 (P < .01) with a PGA cutoff value of 1.38; the AUC for disease activity based on the BASDAI was 0.715 (P < .01) with a PGA cutoff value of 1.63. The PGA was significantly correlated with patient-reported outcomes, disease activity, function, and psychological status, and may indicate the level of inflammation in patients with AS. A PGA of around 1.5 indicates disease activity.
PROBLEM TO BE SOLVED: To obtain a newly confirmed polynucleotide, human inositol monophosphatase H1 and a polypeptide coded by the polynucleotide. SOLUTION: Human inositol monophosphatase H1 (hIMP-H1) polynucleotide, a DNA (RNA) for coding the polypeptide and a method for producing the polypeptide by a recombination technique are claimed. A method for using the polypeptide, e.g. by designing and screening a compound capable of inhibiting hIMP-H1 and making a map for gene diseases is claimed. Further, an antagonist to the aforesaid polypeptide and a method for using the antagonist to the polypeptide for the purpose of curing, e.g. for treating mental diseases and depressive disorders, are claimed.
Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15. Patients also receive carboplatin, bevacizumab, and veliparib as in Regimen I. Treatment repeats every 21 days for 6 courses. Patients then receive bevacizumab alone on day 1. Treatment with bevacizumab repeats every 21 days for 16 courses in the absence of disease progression or unacceptable toxicity.
PURPOSE: To obtain an ethylenically unsatd. bile acid deriv. having an ethylenically unsatd. group bonded to a bile acid deriv. through a bridge group and used as starting material for the preparation of a polymeric bile acid deriv. which inhibits the re-absorption of bile acid in the small intestine and is useful as a lipid in blood degradation medicine.  
     CONSTITUTION: A bile acid deriv. of formula I [where R 3  to R 8  are each H, (protected) OH or ON 2 ; and B is OH, an O-alkali metal, O-alkaline earth metal, O-1-12C alkyl, O-allyl or the like] is sulfonylated by reaction with methanesulfonyl chloride or the like, a bridge group is introduced by reaction with an ω-alkanediol under heating in the presence of a base and the resultant compd. is sulfonylated by reaction with methanesulfonyl chloride, azidated by reaction with sodium azide or the like, derived to an amino group by reduction with a Pd catalyst and then allowed to react with acrylic acid chloride, maleic anhydride or the like to obtain the objective ethylenically unsatd. bile acid deriv. of formula II (where G is the bile acid deriv. of the formula I; X is the bridge group; and A is a polymerizable ethylenically unsatd. group). 
     COPYRIGHT: (C)1994,JPO
Ethylenically unsaturated compounds are polymerized in the presence of an organic peroxide, a tertiary amine and a triester of phosphorous acid.  The monomer may be an ester of acrylic or methacrylic acid.  The triester may be tris-(b -chlorethyl) phosphite or tris-octyl phosphite.  The tertiary amine may be dimethyl aniline or diethyl aniline.  The peroxide may be benzoyl peroxide.  The polymerizable composition may also contain finely divided polymer of the monomer to be polymerized, ultra-violet light absorbers, e.g. 2,4-dihydroxybenzophenone, and other co-catalysts and accelerators.
Arm 2 patients will be treated using a daily escitalopram treatment. Treatment will be taken in the morning. Treatment will be initiated at 10 mg daily and gradually increased depending on symptom control and side effects. Treatment doses will be adapted for 5 mg for old patients.
Cardiomyocyte proliferation is a challenging metric to assess. Current methodologies have limitations in detecting the generation of new cardiomyocytes and technical challenges that reduce widespread applicability. Here, we describe an improved cell suspension and imaging-based methodology that can be broadly employed to assess cardiomyocyte cell division in standard laboratories across a multitude of model organisms and experimental conditions. We highlight additional metrics that can be gathered from the same cell preparations to enable additional relevant analyses to be performed. We incorporate additional antibody stains to address potential technical concerns of miscounting. Finally, we employ this methodology with a dual-thymidine analog-labeling approach to a post-infarction murine model, which allowed us to robustly identify unique cycling events, such as cardiomyocytes undergoing multiple rounds of cell division.
The emergence of long COVID during the ongoing COVID-19 pandemic has presented considerable challenges for healthcare professionals and researchers. The task of identifying relevant literature is particularly daunting due to the rapidly evolving scientific landscape, inconsistent definitions, and a lack of standardized nomenclature. This paper proposes a novel solution to this challenge by employing machine learning techniques to classify long COVID literature. However, the scarcity of annotated data for machine learning poses a significant obstacle. To overcome this, we introduce a strategy called medical paraphrasing, which diversifies the training data while maintaining the original content. Additionally, we propose a Data-Reweighting-Based Multi-Level Optimization Framework for Domain Adaptive Paraphrasing, supported by a Meta-Weight-Network (MWN). This innovative approach incorporates feedback from the downstream text classification model to influence the training of the paraphrasing model. During the training process, the framework assigns higher weights to the training examples that contribute more effectively to the downstream task of long COVID text classification. Our findings demonstrate that this method substantially improves the accuracy and efficiency of long COVID literature classification, offering a valuable tool for physicians and researchers navigating this complex and ever-evolving field.
ESML-SOCIAL consists of four weekly 90-minute seminars. Each seminar includes discussion of a specific topic, open time for socializing, and a "homework" assignment to be completed prior to the next session. Seminars are carried out in small groups of five to six participant/care partner dyads (10-12 people total), to ensure everyone in the seminar gets individual attention and that everyone has a chance to bring up any concerns.
Lung cancer stands prominently among the foremost contributors to human mortality, distinguished by its elevated fatality rate and the second-highest incidence rate among malignancies. The metastatic dissemination of lung cancer stands as a primary determinant of its elevated mortality and recurrence rates, underscoring the imperative for comprehensive investigation into its metastatic pathways. Circular RNAs (circRNAs), a subclass of non-coding RNA (ncRNA) molecules, have garnered attention for their pivotal involvement in the genesis and advancement of lung cancer. Emerging evidence highlights the indispensable functions of circRNAs in orchestrating the metastatic cascade of lung cancer. This review primarily discusses the mechanisms by which circRNAs act as competitive endogenous RNAs (ceRNAs) and modulate various signaling pathways to regulate lung cancer metastasis. CircRNAs influence critical cellular processes including angiogenesis, autophagy, and glycolysis, thereby exerting influence over the metastatic cascade in lung cancer. These discoveries offer innovative perspectives and therapeutic avenues for the diagnosis and management of lung cancer.
PURPOSE: An RNA aptamer is provided to detect staphylococcus by specifically binding to teichoic acid of Staphylococcus aureus, to suppress activity of Staphylococcus aureus, and to prevent food spoilage. CONSTITUTION: An RNA aptamer has a base sequence of sequence number 1 which specifically binds to teichoic acid of Staphylococcus aureus. Urecil(U) and cytosine(C) of sequence number 1 have 2' hydroxyl group which is substituted with a fluorine group. A biosensor for detecting Staphylococcus aureus contains the RNA aptamer. A pharmaceutical composition for preventing or treating diseases selected from the group consisting of staphylococcal pneumonia, sepsis, osteomyelitis, staphylococcal enteritis, food poisoning, staphylococcal scalded skin syndrome(SSSS), and toxic shock-like syndrome(TSS) contains the RNA aptamer. A food additive composition contains the RNA aptamer.
Obstructive sleep apnea (OSA) is characterized by recurrent airway collapse that causes chronic intermittent hypoxia(CIH). OSA is associated with systemic inflammation and oxidative stress resulting in endothelial dysfunction and cardiovascular disease (CVD). Under physiological conditions, eNOS is activated by shear stress and Ach. L-arginine and O2 are catalyzed by BH4, FMN, FAD, NADPH, and eNOS to produce nitric oxide (NO)， which has an important vasodilating effect， and L-citrulline. During the episode of OSA, intermittent hypoxia leads to oxidative stress resulting in the production of superoxide anions. The reaction between O2- and NO occurs rapidly, resulting in ONOO-. ONOO- and H2O2 oxidize BH4 to dihydrobiotrexate (BH2), which is a competitive inhibitor with BH4, thus limiting the availability of eNOS substrates and preventing NO production, resulting in an imbalance between contraction and diastolic. It has been documented that beat-to-beat blood pressure variability in OSAS patients is much higher than that in healthy adults. In some patients, intermittent hypoxia was observed with the episode of OSA, and blood pressure fluctuated with the episode of hypoxia. However, this was not found in the other patients, whose blood pressure did not change significantly during the hypoxia episode. Therefore, the investigators considered that the endothelial function of patients with high sensitivity to hypoxia was healthy or in the early stage, while the endothelial function of those patients with low sensitivity to hypoxia was at a relatively high level of impairment. Endothelial dysfunction can be measured indirectly by brachial artery flow-mediated dilation (FMD), beat-to-beat blood pressure variability can be measured by Polysomnography (PSG), and biological examinations can be performed by blood sampling. Thus, the purpose is to explore the specific relationship between OSAS beat-to-beat blood pressure variability and endothelial dysfunction.
Project Health will be delivered in six 1-hour group sessions that will be held weekly. In addition, participants will be asked to complete 30 mins of response inhibition and attention trainings once per week between the sessions. This program promotes to retain the gradual lifestyle modification designed to bring energy intake into balance with energy output and the food response inhibition and attention training, but will adapt the dissonance-induction activities to focus on the negative effects of developing T2D in addition to the negative effects of obesity, overeating, and a sedentary lifestyle.
Participants will use subcutaneously-delivered BC LisPram through pump therapy. During dual wave bolusing, 50% of the prandial bolus is delivered immediately, and the other 50% delivered over the next 30 minutes.
At Providence Saint John's Health Center, there is the ongoing integration of Intra-Operative Radiation Therapy (IORT) as a standard treatment option among Breast Conserving Therapy (BCT) for individuals with in situ and early stage breast cancer. Currently, approximately 60 women per year are being treated with IORT. No repository of information of patient outcomes with this treatment has been established. This leaves a critical gap in the ability to assess the long-term outcomes of patients treated with IORT.

As the practice of using IORT to treat early stage and in situ breast cancer continues to grow at Providence Saint John's Health Center, this registry will provide the data needed to compare patient outcomes with those being treated with the traditional whole breast radiation therapy. In addition, the Providence Health \& Services strives to improve patient care and outcomes with excellence whenever possible. The registry will provide the data needed to compare patient outcomes to national and community standards that can inform internal practice patterns and contribute to advancing breast cancer care nationally and internationally.
Aim: This study assessed the clinical impact and cost-effectiveness of switching from tenofovir disoproxil fumarate (TDF) to either tenofovir alafenamide (TAF) or entecavir (ETV) in a Greek chronic hepatitis B (CHB) population. Patients & methods: A Markov model from the perspective of a third-party payer in Greece quantified the health and economic benefits of switching from TDF to either TAF or ETV over a lifetime horizon. Results: Over a lifetime, patients who switch from TDF to TAF versus patients who switch from TDF to ETV had an overall lower incidence of compensated cirrhosis (0.4% lower), decompensated cirrhosis (0.04% lower) and hepatocellular carcinoma (0.25% lower). Chronic kidney disease and end-stage renal disease were also lower in patients who switch to TAF; major osteoporotic fractures were similar for both groups. While total costs were higher for switching from TDF to TAF versus TDF to ETV due to the higher cost of TAF, switching from TDF to TAF versus ETV was cost effective with an incremental cost-effectiveness ratio of €17,113 per quality-adjusted life year. Conclusion: Switching from TDF to TAF in patients living with CHB is a cost effective strategy to reduce adverse liver disease outcomes, while improving bone- and renal-related safety outcomes.
As a defense mechanism against deleterious stimuli, inflammation plays a vital role in the development of many disorders, including atherosclerosis, inflammatory bowel disease, experimental autoimmune encephalomyelitis, septic and non-septic shock, and non-alcoholic fatty liver disease (NAFLD). Despite the serious adverse effects of extended usage, traditional anti-inflammatory medications, such as steroidal and non-steroidal anti-inflammatory medicines (NSAIDs), are commonly used for alleviating symptoms of inflammation. The PPARδ subtype of peroxisome proliferator-activated receptors (PPARs) has attracted interest because of its potential for reducing inflammation and related disorders. In this study, a series of 1,3,4-thiadiazole derivatives were designed, synthesized, and evaluated. Compound 11 exhibited potent PPARδ agonistic activity with EC50 values 20 nM and strong selectivity over PPARα and PPARγ. Furthermore, compound 11 demonstrated favorable in vitro and in vivo pharmacokinetic properties. In vivo experiments using labeled macrophages and paw thickness measurements confirmed compound 11's potential to reduce macrophage infiltration and alleviate inflammation. These findings highlight compound 11 as a potent and promising therapeutic candidate for the treatment of acute inflammatory diseases and warrant further investigation to explore various biological roles.
PURPOSE: A method for preparing ivabradine, an additional salt thereof with a pharmaceutically acceptable acid, and a hydrate thereof, and a drug are provided to synthesize ivabradine without jewelry. CONSTITUTION: A method for synthesizing ivabradine of chemical formula I comprises a step of reductive amination of a compound of chemical formula V and amine of chemical formula VI in an organic solvent or a mixture of the organic solvent at 25-100 deg. C at a dihydrogen pressure of 1-20 bar under the presence of iron-based catalyst, and the presence or absence of trimethyl amine N-oxide. The iron-based catalyst has a structure of chemical formula VII. The amount of a catalyst in the reductive amination is 1-10 mol% based on aldehyde. The amount of trimethyl amine N-oxide is 1-3 equivalent based on the catalyst.
The performance of stroke patients' daily living activities (ADLs) is severely affected because of hemiplegia. The consequences of stroke on patients can lead to a financial and welfare burden on society. Thus, it is vital to provide a rehabilitation program to enhance patients' performance in ADLs and help them become more independent. This study aims to evaluate the efficacy of telerehabilitation on stroke patients' capability to perform ADLs after three months of telerehabilitation intervention. Additionally, the investigators also conduct a survey on the satisfaction of patients after telerehabilitation. The investigators will recruit 32 stroke patients from five hospitals in Vietnam. All subjects will be provided the three-month treatment that includes video-based rehabilitation and the online meeting section. The investigators will use the Barthel Index (BI) to evaluate the intervention and use the Paired T-test to review the results. Evaluation of the satisfaction of stroke patients with telerehabilitation is conducted by Telemedicine Satisfaction and Usefulness Questionnaire (TSUQ).
1496102 Shampoo KAO SOAP CO Ltd 14 Sept 1976 [16 Sept 1975] 38011/76 Heading C5D A liquid shampoo composition comprises 10-40 wt. per cent of an anionic surface active agent having the formula where R, is a C 10 -C 18  alkyl, n is the average mole number of added ethylene oxide units and is in the range 1-5 with the proviso that not more than 5 wt. per cent of the compounds are n=0, and M is an alkali metal or an organic amine; 0À1-5 wt. per cent of a cationic surface active agent having the formula where R 2  is a C 16 -C 22  alkyl, R 3  and R 4 , which may be the same of different, are C 1 -C 2  alkyl, R 5  is a C 1 -C 2  alkyl or benzyl, and X is an anionic group, preferably Cl-, Br-, I- or monoethylsulphate; and water. Optional ingredients include 1-8 wt. per cent of a higher fatty acid alkanolamine, 0À1-5 wt. per cent of a non-ionic surfactant, such as polyoxyethylene alkyl ether, 0À1-3 wt. per cent NaCl, and 0À1-2 wt. per cent of an oil component such as a higher alcohol or isopropylmyristate. Other optional ingredients include antioxidants, chelating agents, ultraviolet absorbers, fungicides, prevervatives, perfumes, and dyes. Examples of shampoos according to the invention comprise a sodium polyoxyethylene lauryl ether sulphate, stearyl trimethyl or stearyl dimethyl benzyl ammonium chloride, coconut fatty acid or lauroyl diethanolamide, perfume, dye, and deionized water.
Online learning materials are of great importance in health education where theoretical knowledge and psychomotor skills are developed. The student takes responsibility for learning and has the chance to continue his education outside the classroom. Concept maps are one of the most effective educational materials both in classroom education and online learning. Visual education is concept map training in which each concept is included once on concrete applications and the relationships between concepts are revealed within the framework of the main lines to be taught. Providing parenteral drug administration training with a concept map will reveal the application steps as a concrete step and clear away confusing theoretical knowledge. The use of concept maps will ensure that first-year nursing students who are receiving training on drug administration for the first time will receive an education that is summative and memorable, away from the complex structure. One of the education models that offer interactive education opportunities other than traditional ones is blended learning. Blended learning provides a combination of face-to-face and technology-mediated teaching and learning that not only fully embodies the concept of \"student-centered\" teaching but also enables students to effectively participate in the classroom. The student-centered nature of blended learning also brings about self-directed learning. Self-directed learning is defined as the process of constantly monitoring and improving students\' cognitive states, observing and applying various learning strategies, helping them recognize learning behaviors, and making efforts to create and use physical and social resources that facilitate learning.
Interferons can be modified by (a) enzymic introduction of a terminal sialic acid residue, using a sialic acid donor, e.g. CMP-N-acetyl nemaminic acid and a silyl transfer ase, at pH 5.5-8.0, (b) oxdn. of the terminal galactose residue of an asialo-interferon with galactose at pH 7.0-8.0, (c) removal of the terminal galactose residue of an asialo-interferon with a beta-galactosidase at pH 3.5-6.5, (d) biosynthesis under modifying conditions, i.e. in the presence of a glycosyl transferase inhibitor, e.g. 2-deoxyglucose. (Modified) interferous can be purified by affinity chromatography using an agglutin immobilised or activated agarose.