anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Gabapentin is described as 1-(aminomethyl) cyclohexaneacetic acid with a molecular formula of C 9H 17NO 2 and a molecular weight of 171.24. Gabapentin is a white to off-white crystalline solid with a pKa1 of 3.7 and a pKa2 of 10.7. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is -1.25. It has the following structural formula: 

Gabapentin film-coated tablet, USP for oral administration contains 600 mg and 800 mg of gabapentin. In addition, each tablet contains the following inactive ingredients: copovidone, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol and titanium dioxide.
The intervention course consisted of 3 hour-long sessions on communication delivered over a 4-month period. It differed from the control course in subject matter and pedagogy. Subject matter focused on specific skills used in communication: reflective listening, responding to emotion, and providing information within a broad range of communication scenarios. In terms of pedagogy, the intervention course was interactive with a focus on skills practice, communication drills, and improvisation to engage learners. The sessions consisted of fifteen minutes of lecture and 45 minutes of skills practice.
The present disclosure relates to active particle-enhanced membrane and methods for making and using the same. In some embodiments, a breathable membrane includes a base material solution and active particles. The active particles incorporated in the membrane may improve or add various desirable properties to the membrane, such as for example, the moisture vapor transport capability, the odor adsorbance, the anti-static properties, or the stealth properties of the membrane. In some embodiments, the base material may exhibit water-proof properties when converted into non-solution state, and thereby result in a water-proof membrane. In some embodiments, the active particles may be protected from losing activity before, during, or after (or any combination thereof) the process of producing the membrane. The membrane may be applied to a substrate, or may be used independent of a substrate.
The selection of appropriate doses for Part B will be performed upon consideration of available safety and tolerability and PK data from Part A and/or any preceding repeat dose cohorts. The subjects will receive GSK2849466 in ratio of 3:1.with placebo. In Cohort 4 subjects will be dosed in the fasted state on Days 1 and 14 and in the fed state on Day 7.
All patients will receive shockwave treatment (6 sessions for all subjects, 5000 shockwaves at each session, at energy level 7), twice per week (total of 3 weeks) without treatment interval. Starting at first LiST session and finishing one week after final LiST session, subjects will receive for 4 weeks daily Tadalafil 5mg. Total treatment period = 4 weeks.
BACKGROUND AND OBJECTIVES: Smoking can worsen inflammatory bowel disease (IBD), although evidence regarding the duration of cessation is scarce. The objectives of the study were to determine the duration of abstinence and identify the characteristics of relapse in IBD patients.
PATIENTS AND METHODS: Using the local database of a nationwide registry of patients with IBD, we identified patients who were active smokers at the time of IBD diagnosis and invited them to participate in the study. Patients were asked about their smoking habit and those who were ex-smokers constituted the study cohort. We obtained clinical and smoking-related data of ex-smokers from medical records and telephone interviews. We measured nicotine dependence using the Fagerström Test for Nicotine Dependence (FTND).
RESULTS: We enrolled 121 IBD patients who were ex-smokers: 89 patients with Crohn's disease (CD) and 33 patients with ulcerative colitis (UC). The median age at cessation was lower in patients with CD (38 years) than in patients with UC (46 years) (p=0.002). Follow-up time was shorter in CD patients than in UC patients (114 vs. 168 months, p=0.035). No difference was found in the FTND score. Relapse was more common in CD patients (46%) than in UC patients (24%) (p=0.029), although time to first relapse was similar in both groups of patients (12 and 15 months, respectively; p=0.056). Nicotine dependence was the only independent factor associated with relapse.
CONCLUSIONS: The risk of smoking relapse was high, especially in CD patients, although their dependence level was similar to that of UC patients.
Sickness absence due to psychiatric problems is considered a growing problem in Norway. Little research is done to examine if psychotherapy can reduce sickness absence. Since 2007 there is a government sponsored program in Norway (Raskere tilbake) aimed at reducing sickness absence. This study examines if psychotherapy within this program, delivered at an out-patient clinic, actually reduces sickness absence. Levels of absenteeism is measured before, after and 6 months after treatment. This is a quasi-experimental study, where the treatment-group will be compared with a statistical group in the general population, that is socio-demographical similar and has similar history of sickness absence but haven't been to treatment. Changes in levels of symptoms and quality of life will also be measured. The participants will be asked to describe their working environment, and this will be related to outcome-measures.
NEW MATERIAL:The substituted diphenylimidazole derivative of formula I (X is H, halogen, lower alkyl or lower alkoxy; m is 0 or 1; n is 1-4; R is heterocyclic group or cyclic amino; when n=2, R is not 2-pyridyl) and its acid addition salt. EXAMPLE:4,5-Diphenyl-2-(2-pyridylmethyl)thio-imidazole. USE:It has antiulcer and anti-inflammatory actions and is useful as a drug. It has low side effect and high safety. PREPARATION:The compound of formula I can be produced according to the reaction formula, by reacting the compound of formula II with the compound of formula III in a solvent (e.g. methanol) at 20-120 deg.C.
Reduced cerebral blood flow (CBF) in the temporoparietal region and gray matter volumes (GMVs) in the temporal lobe were previously reported in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, the temporal relationship between reductions in CBF and GMVs requires further investigation. This study sought to determine if reduced CBF is associated with reduced GMVs, or vice versa. Data came from 148 volunteers of the Cardiovascular Health Study Cognition Study (CHS-CS), including 58 normal controls (NC), 50 MCI, and 40 AD who had perfusion and structural MRIs during 2002-2003 (Time 2). Sixty-three of the 148 volunteers had follow-up perfusion and structural MRIs (Time 3). Forty out of the 63 volunteers received prior structural MRIs during 1997-1999 (Time 1). The relationships between GMVs and subsequent CBF changes, and between CBF and subsequent GMV changes were investigated. At Time 2, we observed smaller GMVs (p<0.05) in the temporal pole region in AD compared to NC and MCI. We also found associations between: (1) temporal pole GMVs at Time 2 and subsequent declines in CBF in this region (p=0.0014) and in the temporoparietal region (p=0.0032); (2) hippocampal GMVs at Time 2 and subsequent declines in CBF in the temporoparietal region (p=0.012); and (3) temporal pole CBF at Time 2 and subsequent changes in GMV in this region (p = 0.011). Therefore, hypoperfusion in the temporal pole may be an early event driving its atrophy. Perfusion declines in the temporoparietal and temporal pole follow atrophy in this temporal pole region.
Monoclonal antibodies (MAb) against TNF-BPI (tumour necrosis factor-binding protein I), designated tbp-1 and tbp-2 and secreted by the hybridomas TBP-1 and -2, and their active fragments are new. Also new are (1) hybridomas TBP-1 and-2 (ECACC 91060555 and 91060556, respectively) and (2) sandwich immunoassay kits for determn. of TNF-BPI in a sample. More specifically, TNF-BPI is detected by reaction with at least one MAb to form a binary or ternary complex. In partic. a ternary complex is formed esp. where the 1st. antibody is tbp-1 and the 2nd. is tbp-2. USE/ADVANTAGE - MAb provide an efficient and sensitive method for detecting TNF-BPI in body fluids (serum, plasma or urine) and cell culture supernatants. The method is used to diagnose (and monitor) diseases associated with activation of the TNF-receptor system, specifically septic shock but also bacterial infections, graft vs. host disease, cerebral malaria and cachexia. TNF-BPI can be determined at 200 ng/l with reproducibility better than 10% and the presence of TNF in the sample does not affect the assay, even at pathologically elevated levels. MAb can also be used for affinity chromatographic purificn. of TNF-BPI
Kidney diseases pose a significant global health challenge, requiring precise diagnostic tools to improve patient outcomes. This study addresses this need by investigating three main categories of renal diseases: kidney stones, cysts, and tumors. Utilizing a comprehensive dataset of 12,446 CT whole abdomen and urogram images, this study developed an advanced AI-driven diagnostic system specifically tailored for kidney disease classification. The innovative approach of this study combines the strengths of traditional convolutional neural network architecture (AlexNet) with modern advancements in ConvNeXt architectures. By integrating AlexNet's robust feature extraction capabilities with ConvNeXt's advanced attention mechanisms, the paper achieved an exceptional classification accuracy of 99.85%. A key advancement in this study's methodology lies in the strategic amalgamation of features from both networks. This paper concatenated hierarchical spatial information and incorporated self-attention mechanisms to enhance classification performance. Furthermore, the study introduced a custom optimization technique inspired by the Adam optimizer, which dynamically adjusts the step size based on gradient norms. This tailored optimizer facilitated faster convergence and more effective weight updates, imporving model performance. The model of this study demonstrated outstanding performance across various metrics, with an average precision of 99.89%, recall of 99.95%, and specificity of 99.83%. These results highlight the efficacy of the hybrid architecture and optimization strategy in accurately diagnosing kidney diseases. Additionally, the methodology of this paper emphasizes interpretability and explainability, which are crucial for the clinical deployment of deep learning models.
A number of school aged children from Uganda. Children from 5-7 different schools will be in the group.
Down-regulation started on day 20 of the previous cycle by GnRH agonist triptorelin (0.5 µg Decapeptyl; Ferring). On the second day of menstruation, when down regulation was confirmed (as evidenced by endometrial thickness \<5 mm and/or E2 levels \<50 pg/mL) using transvaginal sonography (TVS) by Voluson 730 Pro (GE, Fairfield, CT) apparatus, gonadotropin (Merional; IBSA) was commenced at an initial dose of 300-450 IU/day for the first 5 days followed by individual adjustment in Gn dose according to ovarian response and the dose of Decapeptyl 50µg/day was continued until day of HCG administration.
The purpose of our study was to investigate the role of TGF-β1 in the endothelial-to-mesenchymal transition (EndoMT) and fibrosis in high glucose (HG)-treated human retinal microvascular endothelial cells (HRMECs). HRMECs were cultured not only under normal glucose (NG) conditions with or without TGF-β1, but also under HG conditions with or without the TGF-β1 inhibitor SB431542. The expression of TGF-β1 was detected by real time-PCR and enzyme-linked immunosorbent assay. Morphological changes and migration of the HRMECs were observed using electron microscopy and scratch-wound assay. Endothelial markers, such as CD31 and vascular endothelial (VE)-cadherin, and the acquisition of fibrotic markers, such as alpha smooth muscle actin (α-SMA) and fibroblast-specific protein-1 (FSP-1), were determined by immunofluorescent staining and western blot. The level of TGF-β1 was significantly upregulated in HG-treated HRMECs. And HG stimulation promoted obvious morphological changes and the migration ability in HRMECs. Our results also demonstrated increased expression of α-SMA and FSP-1, and decreased expression of CD31 and VE-cadherin, in HG-treated HRMECs. These EndoMT-related changes were promoted by TGF-β1 and abrogated by SB431542. The results of this study demonstrated the important role of TGF-β1 in HG-induced vitreoretinal fibrosis. EndoMT is likely to be involved in the associated effects.
Patients will be given cholecalciferol 10,000 IU daily for 30 days. \<-THIS IS THE INTERVENTION. At that point, if their vitamin D levels remain below 50 ng/ml, the 30 day course will be repeated. For patients who enroll in the summer, levels will be rechecked in March and if \<50 ng/ml, a 30 day course will be administered.
This invention discloses an apparatus for extraction of constituents with extraction fluid present in a substance by means of an extraction fluid constituted by a water heated to high temperature known as super-heated water (SHW). According to this invention, in the heater the water is heated to a subcritical point and introduced to the extractor contacting takes place between the substance and the extraction fluid to dissolve the constituents in the fluid. The fluid leaving the extractor is then cooled in a cooler. The process is performed under constant counter pressure given by a Nitrogen tank. Separation of the volatile components is done in one or multistage countercurrent liquid-liquid system with any volatile solvent with proper solubility of the constituents or in a distillation column. distillation column.
The invention discloses acetyl dithranol paste and a preparation method thereof. The acetyl dithranol paste comprises, by mass, 0.12-1.20% of acetyl dithranol with the grain diameter from 10 mu m to 80 mu m and 98.80-99.88% of white Vaseline. The preparation method comprises steps of grinding the acetyl dithranol until the grain diameter is in a range from 10 mu m to 80 mum; heating and melting the white Vaseline, filtering the white Vaseline when the white Vaseline is hot, removing impurities, heating the white Vaseline at the temperature from 145 DEG C to 155 DEG C, preserving the temperature for 1-2 hours, conducting sterilization and removing water; and grinding and mixing a little white Vaseline and smashed acetyl dithranol when the temperature of the white Vaseline lowers to the range from 45 DEG C to 55 DEG C, adding the mixture to a residual substrate, stirring evenly for 15-30 minutes, mixing the main medicine and the substrate evenly, cooling, conducting solidification and obtaining the acetyl dithranol paste. The acetyl dithranol paste is uniform and smooth. The acetyl dithranol paste can be applied to the skin easily and the medicine is easy to absorb. Compared with acetyl dithranol paste in the market, the acetyl dithranol paste has identical curative effect and little side effect.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Most patients with RA face a barrier to participation in social activities or exercise due to joint pain, despite the beneficial effects of exercise and physical activity. Thus, RA may be a risk factor for sarcopenia in the clinical field. Bioelectrical impedance analysis-derived phase angle (PhA) reflects cellular health and is correlated with the prognosis of various diseases. However, its association with physical function in non-sarcopenic RA female patients remains unclear. We evaluated the association between PhA values and various physical function measures in female patients with non-sarcopenic RA. Methods: Thirty-five participants with RA were screened. One met the criteria for sarcopenia. Finally, 34 patients with non-sarcopenic RA were enrolled. This cross-sectional retrospective study evaluated upper- and lower-extremity strengths, cross-sectional area of rectus femoris, 6 min walking test, Borg scale score, sit-to-stand test, and physical function and mental health from 36-Item Short Form Health Survey scores. Results: In total, 34 female participants (mean age = 49.74 ± 8.15 years) were enrolled. In non-sarcopenic RA patients, PhA was significantly correlated with BMI and ASM/(height)2. Multicollinearity was not detected among the independent variables (VIF < 5). The final multivariable regression model identified ASM/height2 as a significant predictor of PhA among non-sarcopenic RA patients. Conclusion: Multivariable linear regression analyses identified appendicular skeletal muscle mass as a significant predictor of PhA. Bioelectrical impedance analysis-derived PhA is a valuable guidance tool for RA management. PhA can be a useful clinical biomarker of muscle status in non-sarcopenic RA patients.
One injection of cAd3 will be administered to the study participants at enrollment. The participants will be monitored for 30 minutes after receipt of the vaccine and thereafter follow up done at different time points up to 72 months.
A matrix for supporting cells such as animal cells is provided that enables cells to be supported at high efficiency and density in a short period. The matrix contains a plurality of cone shaped pores having an average diameter opening in an upstream surface of the matrix of from 500 to 1500 mum. The diameter decreases from the upstream surface to a downstream surface, and the average diameter of the cone shaped pores in the whole matrix is from 100 to 1000 mum. The matrix also contains a plurality of communicating pores that communicate with the cone shaped pores and with each other. These pores have an average diameter of from 5 to 100 mum, and the diameter decreases from a pore opening positioned near one surface of the matrix or near an interior surface of the cone shaped pores to a pore opening positioned remote from the surfaces. The matrix may also contain a plurality of column shaped pores having an average diameter of 100 to 1000 mum. A porous skin layer having an average pore size smaller than the average pore size of the communicating pores may be on the downstream surface, and the matrix may be made of polyurethane.
Vitamin-A acid panthenol ester is prepared by adding dropwise under nitrogen a benzene solution of vitamin-A acid chloride to a cooled (0 DEG C.) solution of d-panthenol in pyridine/benzene and raising the temperature to 50 DEG C. for 2 hours after 30 minutes. After ether extraction and drying the ester may be purified by chromatography on alumina.  The mono glyceryl ester is prepared by a similar process whereby vitamin-A acid chloride is reacted with acetonyl-glycerine to give the vitamin-A acid acetonyl-glycerol ester which gives the mono-glyceryl ester on heating under nitrogen a solution thereof in an ether/acetone/acetic acid mixture.ALSO:Cosmetic compositions comprise a cosmetic or pharmaceutical base and Vitamin-A acid or an ester thereof, e.g. in a quantity of about 0.01 to 1% by weight. Suitable esters are those with monohydric alcohols and polyhydroxy alkanes containing up to 7 carbon atoms, e.g. sugars, glycerine and panthenol, the alcohol derived radical optionally being further substituted by araliphatic, cycloaliphatic or heterocyclic radicals which, in turn may bear carboxy, carbalkoxy, hydroxy and/or amino groups. Cosmetic forms mentioned are creams, pomades, salves, brilliantines and hair lotions.  Optional ingredients include substances conventionally used for the care of the skin, e.g. lanolin and lecithin.
INTRODUCTION: Occupational therapists working in low vision rehabilitation make recommendations for assistive technology (AT) and provide training in AT use for people with vision impairment (PVI) to support participation and independence. Smartphones and apps are an important AT for PVI, yet little is known about the training needs of PVI or what training is currently provided. Research exploring PVI's learning and training experiences is required to inform training development.
PURPOSE: This study aimed to explore the perspectives, needs, and recommendations of PVI from Australia and Singapore on smartphone training methods.
METHODS: An online survey collected data between November 2020 to February 2021. Participants were recruited from Australia and Singapore using purposeful sampling. The survey had three sections: (i) demographics, (ii) use of smartphones and apps, and (iii) training. It consisted of 26 closed and open-ended questions. The quantitative results from the survey were analysed descriptively, and responses to open-ended questions were analysed using content analysis.
RESULTS: Sixty-eight PVI responded to the survey, with 34 (50%) participants from each country. There were more Australians (n = 19/34, 55.9%) who had accessed formal training compared to Singaporeans (n = 11/34, 32.3%). Participants valued both formal and informal training, and self-training was the most used method for informal training (Australia: n = 29/34, 85%, Singapore: n = 22/34, 64.7%). Participants stated they preferred individualised formal training that caters to their learning needs and is provided by patient and knowledgeable trainers. They also preferred formal training, which is flexible and convenient to access, including online training with peers.
CONCLUSION: Findings such as providing individualised training, ensuring increased awareness of formal training, and using both formal and informal training methods can be considered by occupational therapists to enhance and develop training for PVI in the use of smartphones and apps.
CONSUMER AND COMMUNITY CONSULTATION: Consumers were involved at the development stage. Three people with vision impairment reviewed and provided feedback on the survey's accessibility and content.
Multiple risk factors contribute to the causation of atherosclerotic cardiovascular disease. Past studies indicate that exercise exerts its protective effects on the disease through actions on multiple cardiovascular risk factors simultaneously; however, the studies focused on the effect of exercise predominantly on subjects with a single risk factor. Does exercise differentially act on various risk factors in the same subject? Do subjects with multiple risk factors respond differently to exercise than those predominantly with a single risk factor do? To our knowledge, this is the first large-scale study to test the efficacy of exercise on subjects with multiple risk factors. Exercise in fitness clubs has uniquely fitting features for middle to older aged people with multiple risk factors: access is relatively easy because there are usually many clubs throughout the city; the control of exercise intensity or heart rate is made precise, rendering exercise safer when treadmills or bicycles are used as a mainstay of aerobic exercise as in this study; and cardiac arrest, the most feared complication of exercise, will be most likely to be properly handled since in recent years the installment of automated external defibrillators has been increasingly popular in many clubs.

Comparison: Exercise vs. standard care comparison is to be made only for the first 6-month period. The second 6-month period is for follow-up and other purposes.
Patients participate in online nutritional counseling over 30 minutes in weeks 1, 3, 5, 7, 9, and 11, and participate in online resistance training sessions weekly over 30 minutes in weeks 1-6 and biweekly at weeks 8, 10, and 12. Patients also receive educational materials at baseline.
The program is a comprehensive CBT program lasting 12 weeks, with as many modules. The modules are quite extensive. A guide with basic education in psychotherapy assists and counsels participants online.