anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Forced postures are common in the workplace. Work in the primary economic sector is characterised by a high degree of physical activity and movement; however, activities in the secondary and tertiary sectors commonly require workers to stand or sit. An expansion of the tertiary sector in recent decades has meant that people in industrialised and emerging economies primarily sit or stand at work. The aim of the systematic review was to identify occupational factors relating to the presence of chronic venous disease (CVD), to place these in the context of developments in the workplace, and to determine whether measures are in place to prevent CVD. We performed a systematic literature review to analyse studies assessing work-related risk factors for CVD. We searched for publications in the PubMed database, the clinic library of BG Hospital Bergmannstrost Halle, and the registry of the German Statutory Accident Insurance. Using occupation-specific keyword combinations, we identified 27,522 publications. The publications underwent an automatic and manual filtering process according to the PRISMA guidelines and 81 publications qualified for the review. Ultimately 25 studies were included in the systematic review. All of the subjects of the studies worked in the secondary and tertiary sectors. No studies looked at the relationship between venous disorders and primary sector occupations. Standing at work for more than four hours a day, repeated heavy lifting, and cumulative time working in a sitting or standing position are risk factors for the development of CVD. Sitting is less of a risk factor than standing or walking. Occupational history and the patient's activity profile are important diagnostic tools which can help confirm a diagnosis and justify treatment when findings are inconsistent. Compression therapy is the primary form of secondary and tertiary prevention. There continues to be a lack of primary preventive measures related to workplace design.
<P>PROBLEM TO BE SOLVED: To obtain a flavor deterioration inhibitor having excellent safety, and giving no affection to the original flavor of food and drink, oral health agents, or the like; namely, a flavor deterioration inhibitor inhibiting flavor deterioration caused mainly by light, heat or oxygen in respective steps of production, distribution and storage.  <P>SOLUTION: This flavor deterioration inhibitor comprises an extract from Syzygium malaccense Merr. et Perry and/or Euphoria longana Steud. seeds. The flavor deterioration inhibitor is added to food and drink, oral health agents or spices to inhibit flavor deterioration caused by light or oxidization.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
CONTEXT: This study explores the influence of COVID-19 public health mandates on people with mobility disabilities in the United States in their everyday lives. It highlights the intersection of disability with social determinants of health, emphasizing the need for a comprehensive policy response.
METHODS: Qualitative data were collected through 76 semi-structured interviews with people with mobility disabilities. Interviews focused on experiences with COVID-19 mandates and community access, analyzed using thematic analysis and coded for emergent subthemes.
RESULTS: The relationship between community participation and COVID-19 compliance was complex for people with disabilities. Inaccessible environments and inflexible policies made it difficult for people with disabilities to practice good safety measures, while widespread noncompliance by community members limited their community participation. The findings revealed additional mixed lived experiences of COVID-19 policies on community participation, accessibility, and access to resources and support. While technology facilitated some aspects of community participation, issues with accessibility, public transportation, and personal assistance services were exacerbated.
CONCLUSION: COVID-19 policies have complex implications for people with mobility disabilities. Findings suggest a need for inclusive policymaking, improved disability awareness, and continued support for accessible technology and services. Future research should further explore these dynamics to inform policy and practice.
Once-daily gabapentin tablets are not interchangeable with other gabapentin products.

Titrate gabapentin tablet to an 1,800 mg dose taken orally once daily with the evening meal. Gabapentin tablets should be swallowed whole. Do not split, crush, or chew the tablets. 

If gabapentin dosing is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of one week or longer (at the discretion of the prescriber). 

In adults with postherpetic neuralgia, gabapentin therapy should be initiated and titrated as follows:
The salts are prepd. by adding nutritive substances, such as nitrates or phosphates, to sea water in a vessel, then inoculating the mixture with phytoplankton cells. After 10 days when the number of cells has considerably increased the culture medium is filtered and the filtrate is evaporated and dried under vacuum at 40-50 degrees C. The product is used wither (a) as bath salts or in cosmetic products or (b) as a food supplemtn. As (a) it has a sea odour, a soft consistency and is nutritive to the epidermic cells; and (b) it is beneficial as a result of the synthesised substances such as vitamins that it contains. The phytoplankton cells are pref. diatom, specifically Chaetoceras teres and/or Asterionella japonica. In the prepn. the culture is pref. filtered first through nylon mesh of 100 mu dia. and then through material of 10-0.5 mu mesh dia.
Autologous Peripheral Blood Progenitor Cell Transplantation

The recommended dose is 250 mcg/m2/day administered intravenously over 24 hours or subcutaneously once daily beginning immediately following infusion of progenitor cells and continuing until an ANC greater than 1500 cells/mm3 for three consecutive days is attained. Do not administer LEUKINE within 24 hours preceding or following receipt of chemotherapy or radiotherapy.

Autologous Bone Marrow Transplantation

The recommended dose is 250 mcg/m2/day administered intravenously over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. Do not administer LEUKINE until the post marrow infusion ANC is less than 500 cells/mm3. Continue LEUKINE until an ANC greater than 1500 cells/mm3 for three consecutive days is attained. Do not administer LEUKINE within 24 hours preceding or following receipt of chemotherapy or radiotherapy [see Warnings and Precautions (5.3)].
A substance for poxvirus molluscum infection treatment that includes a mixture of anacardium occi dental e seeds and sunflower oil is disclosed. The mixture is obtained by the washing, drying, and grinding of at least seven anacardium occi dental e seeds. The grinded seeds are then mixed in with at least one cup of sunflower oil. The mixture is then heated under a low temperature for a duration of at least ten minutes until the seeds are in a liquid or semi-liquid state. The temperature is then raised when the mixture begins to change color. The temperature is then lowered once the mixture ceases to produce smoke. The mixture is then strained and poured into sterile bottles which are wrapped in aluminum foil. When applied to a user, the mixture is then placed on a patch which is then placed on an infected area of a user's body.
This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2 and/or proteinuria) occurred in 80,187 participants. In participants without antihypertensive treatment (AHT), the adjusted hazard ratios (95% confidence interval) per 1-standard deviation, that is, 15 mmHg increase in systolic BP for CKD incidence, were 1.08 (1.07-1.09), 1.12 (1.10-1.13), and 1.15 (1.12-1.18) in normoglycemia, borderline glycemia, and diabetes groups, respectively. These ratios were significantly higher in the borderline glycemia and diabetes groups compared with those in the normoglycemia group (interaction p < 0.0001). The interaction between BP and borderline glycemia was evident when the outcome definition was restricted to proteinuria. In participants under AHT, systolic BP was most strongly associated with CKD risk in the diabetes group, although no significant interaction was observed. High BP and high glucose status may synergistically increase the incidence of CKD. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population. This large-scale longitudinal cohort study showed high BP and diabetes synergistically increased the risk of CKD in individuals without AHT. Strict BP management may play an important role in the early prevention of CKD in individuals with worse glucose status within the young and middle-aged population.
Periodic assessment of organ system function, including frequent evaluation of electrolyte balance, hepatic, renal and hematopoietic systems, and cardiac and vascular status should be performed during prolonged therapy with high doses of intravenous penicillin G (see ADVERSE REACTIONS). If any impairment of function is suspected or known to exist, a reduction in the total dosage should be considered (see DOSAGE AND ADMINISTRATION). In suspected staphylococcal infections, proper laboratory studies, including susceptibility tests should be performed. All infections due to Group A beta-hemolytic streptococci should be treated for at least 10 days. 

Patients being treated for gonococcal infection should have a serologic test for syphilis before receiving penicillin. All cases of penicillin treated syphilis should receive adequate follow-up including clinical and serological examinations. The recommended follow-up varies with the stage of syphilis being treated.
In this monocentric study, a double-blind, randomised crossover design was used, with washout periods of at least one week between study days. A standardized meal consisting of two 100 g croissants prepared with sourdough or with brewer's yeast was administered randomly to 17 (9 F; Age range 18-40; BMI range 18-24 kg/m2) healthy subjects after an overnight fast (at least 8 h) and consumed in a 10-minute interval with 300 mL of water. Immediately after meal ingestion, subjects were asked to evaluate croissant palatability. Gastric volume was evaluated by Magnetic Resonance(MR) Imaging to calculate gastric emptying rate in the 3-hour interval following croissant ingestion. Hydrogen breath test was performed to assess gastrointestinal fermentation measuring H2 production after SC and BC ingestion. Postprandial gastrointestinal symptoms and perceptions over a 4-h period after the meal were evaluated by visual analogue scale (VAS). In addition, in the 3-hour interval, blood samples were drawn to measure serum glucose levels. The protocol was repeated twice in each subject, once with sourdough croissants (SC) and once with brewer's yeast croissants (BC), dispensed according to a computer generated randomisation list created by RC following simple randomisation procedures (computerized random numbers). The area under the curve (AUC) was employed to evaluate global kinetics of all parameters and the T-test was used to evaluate differences between groups.
Reddit is one of the world's leading social media platforms, fostering active community discussions on a variety of topics including keloids. The prevalence and reach of conversations on Reddit underscore the need to investigate and understand patient perspectives and gaps in knowledge. Herein, we present an in-depth analysis of questions and concerns of Reddit users on keloids, offering valuable insights into patient experiences, knowledge gaps and treatment preferences. The study presents a distinct approach by harnessing the power of social media data to understand patient perspectives, which may not be readily apparent in clinical settings. All posts on the 'Hot' page of the subreddit r/Keloids were analyzed. Questions were categorized and subcategorized to reveal common themes. A total of 644 questions from 513 posts between 26 March 2017 and 28 August 2023 were identified and analyzed. Reddit users most frequently asked questions regarding keloid management (57.5%). Other common categories included uncertainty regarding diagnosis or symptoms (15.1%), living with keloids (7.5%) and causes or triggers (6.2%). This analysis highlights critical areas of patient knowledge gaps and potential misconceptions regarding keloids. For dermatologists, understanding these patient questions is crucial. Such insights allow for patient-centric education and treatments, ensuring more effective and comprehensive care.
Intramuscular administration of aripiprazole lauroxil to rats and dogs was associated with injection site tissue reactions at all doses in rats treated up to 6 months at doses of 15, 29, and 103 mg/animal (which are approximately 0.3 to 2 times and 0.5 to 3 times the MRHD of 1064 mg on mg/m2 basis in males and females, respectively) and in dogs treated up to 9 months at doses of 147, 662, and 2058 mg/animal (which are approximately 0.5 to 6 times and 0.6 to 8 times the MRHD in males and females, respectively on mg/m2 basis). These injection site tissue reactions consisted of localized granulomatous inflammation and granuloma formation. Transiently impaired limb function and swelling occurred in dogs. The granulomas did not completely resolve 2 months following the last injection in the 6 month rat study and 4 months following the last injection in the 9 month dog study (the low dose groups were not examined for reversibility in these studies). 

Orally administered aripiprazole produced retinal degeneration in albino rats in a 26-week chronic toxicity study at a dose of 60 mg/kg, which is 19 times the oral MRHD of 30 mg/day on mg/m2 basis, and in a 2-year carcinogenicity study at doses of 40 mg/kg and 60 mg/kg, which are 13 and 19 times the oral MRHD on mg/m2 basis and 7 to 14 times human exposure at the oral MRHD based on AUC. Evaluation of the retinas of albino mice and of monkeys did not reveal evidence of retinal degeneration. Additional studies to further evaluate the mechanism have not been performed. The relevance of this finding to human risk is unknown.
Patients in 3D-CTA based perimeter group will undergo CCTA examination before LAAO and a 3D model of the left atrium is reconstructed by a workstation. LAmbre device size selection is based on perimeters of LAA ostium and landing zone which are obtained by the measurement method shown previously in this protocol. After transseptal puncture, LAA angiography is performed with a 6F pigtail catheter in LAA at the tangent angle view which is obtained preoperatively by 3D-CCTA. Then, the outline of the LAA will be drawn on the screen according to the LAA angiography. The process of device implantation, assessment, releasing will be carried out at this tangent angle view. TEE is used to check whether the residual peri-device leaks is less than 5mm. The device will be released if it passes the 'COST' standard; otherwise readjusting the implantation position, change the device size and even re-puncturing transseptal to achieve a better axis will be proceeded.
These will be the same participants from aim 2. All participants will be offered the opportunity to wear the sensors and provide and chose which ones they would prefer to wear. Two participants will be asked to wear the sensor for 48 hours in order to pilot test the feasibility of syncing sensor and MOCHA application data collection.
The PTSD ITP group (CON2) will receive the traditional standard of care (cognitive training and cognitive processing therapy). There is no spaced training or practice.
Patients undergo collection of blood or mouthwash samples. 4-8 weeks later, patients receive a standard follow-up phone call.
An intraoral composition comprising an alkaline active pharmaceutical agent, or a salt thereof, and a chemically bonded ceramic system formed from a substance selected from the group of calcium aluminates, calcium silicates, calcium phosphates, calcium carbonates and mixtures thereof is provided. The alkaline active pharmaceutical agent is preferably nicotine or a salt thereof, such as nicotine bitartrate, or the agent is an opioid analgesic, for example buprenorphine. The composition can be packaged within a permeable sealed bag to form a pouch containing the solid porous chemically bonded ceramic system and the alkaline pharmaceutical agent. The pouch is held within the mouth to release the alkaline active pharmaceutical agent. The chemically bonded ceramic system (alkaline bioceramic) provides a source of alkalinity which facilitates the uptake of the agent into the bloodstream. The composition is preferably in the form of a nicotine pouch, but may also be formulated as a sublingual tablet, buccal tablet, wafer, or lozenge. The composition may be for use in treating one or more symptoms of nicotine dependence, aiding smoking cessation, or ameliorating symptoms associated dementia, Alzheimer’s disease, Parkinson’s disease, Huntingdon’s disease, and depression. The composition may be for use in treating pain.
<P>PROBLEM TO BE SOLVED: To provide an env gene of a new human endogenous retrovirus related to onset of IgA nephropathy.  <P>SOLUTION: An HC2env gene (env gene of the human endogenous retrovirus HC2) is disclosed. One or several bases therein may be deleted, substituted or added. The onset of the IgA nephropathy is a mechanism in which the HC2env gene is expressed to produce an HC2ENV protein that is an expression product thereof. When a human has an antibody reactive with the HC2ENV protein by an autoimmune mechanism, an immunoreactive conjugate of the antibody deposits in a glomerular mesangium region to cause chronic inflammatory reactions.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
PURPOSE:To provide a blood glucose value elevation-inhibiting agent containing a monoterpene glucoside as an active ingredient, inhibiting the digestion of saccharides, suppressing the absorption of the saccharides in small intestines, and useful for the prevention of postcibal blood glucose value elevation and for obesity-resistant activity. CONSTITUTION:The agent contains a compound of the formula (R is H, 1-3C alkyl or alkenyl; OR1 is OH, group capable of being easily derived into the OH), e.g. 1-perillyl-beta-D-glycopyranoside as a main ingredient. A conventional recipient, a conventional preparation carrier, other additives, etc., are further added and then prepared into granules, tablets, capsules, etc. The agent is administered at a dose of 0.1-5mg/kg a day for an adult when orally administered. The compound of the formula specifically inhibits sucrase existing in small intestines, and is thereby useful for hyperglycedmia, obesity caused by the hyperglycemia, adiposis, hyperlipemia, diabete, prediabete, etc. The agent is further useful as a healthy food for the prevention of abnormal metabolisms, as an animal feed additive, etc.
An electronic system facilitates the clinician-patient encounter and serves as a single point of integration for all electronic health care information systems. A physician selects a diagnosis, which is converted from the physician's preferred terminology to a standard ICD diagnosis. The system then proposes a preferred treatment appropriate to the selected diagnosis. The physician can change any items of the proposed treatment plan, with changes being checked against payor rules, prior patient information and selected authorities' guidelines. If a diagnosis or treatment element is not authorized by the payor for the selected diagnosis, the system notifies the physician, allowing changes or offering electronic request for payor authorization. Additionally, the system may indicate those diagnoses for which payor allows said elements, allowing the physician to choose a diagnosis that is consistent with the patient's symptoms and supports the desired treatment. Upon accepting a diagnostic and treatment plan, the plan elements are preferably carried out automatically. For example, payor authorizations are requested as necessary, prescriptions are transmitted to the patient's preferred pharmacy, laboratory tests are ordered, and tests, referrals, and appointments are scheduled electronically.
OBJECTIVES: Evaluation of the results of treatment of adenocarcinoma in situ by loop electrosurgical excision procedure and the safety of a conservative strategy.
METHODS: Identification of all cases of adenocarcinoma in situ treated by loop electrosurgical excision procedure at our institution and follow-up by a conservative strategy. Completeness of the identification of all cases was secured by data from the National Pathology Registry. The treatment strategy was based on cytologic follow-up performed by a general practitioner and, irrespective of margin status of the cone, only the results of the postoperative surveillance were indicative of further treatment.
RESULTS: A total of 224 patients were identified. The overall recurrence rate with a mean follow-up time of 87.8 months was 7.6% (17/224). The recurrence rate in patients with involved margins was significantly higher than in patients with uninvolved margins, 15.7% vs 5.2%, respectively. Six recurrences were diagnosed at first examination 6 months postconization in patients with involved margins. They were treated with hysterectomy in 4 cases and reconization in 1 case. If involvement of margins alone had been an indication of further therapy (hysterectomy or reconization) immediately after conization, the conservative management strategy prevented 46 surgical procedures. Two cases of invasive cancer were diagnosed during follow-up, 150 months and 196 months after primary treatment, and after normal follow-up examinations. These 2 cases must be considered de novo cases and cannot be considered treatment failures.
CONCLUSION: The conservative management strategy thus seems safe, and unnecessary surgical procedures were avoided.
A pharmacologically effective or cosmetic preparation for external application to treat e.g. acne, pimples, ulcers, cold sores. The preparation includes an extract from plants of the grass family of plants, particularly cereals, the extract including juice from green components of the plants at the unjointed stage. The extract is stabilised and carried in a pharmaceutically acceptable aqueous carrier or excipient, the carrier preserving the extract against deterioration and the preparation being capable of at least partial absorption by tissues so as to carry the extract to sub-surface tissues. An anti-microbial agent is included. A second aspect is directed to a preparation which is not necessarily based upon the plant extract and which comprises ascorbic acid and beta-carotene and which may optionally include biotin, trypsin and chlorophyll.