anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The human septum verum represents a small but clinically important region of the brain. Based on the results of animal experiments, the stimulation of its medial part was recently proposed with various indications like epilepsy or cognitive impairment after traumatic brain injury. The aim of our study was to present the anatomical relationships of the human septum verum using fiber dissection and histological analysis to support its research and provide essential information for future deep brain stimulation therapies. 16 human cadaveric brains were dissected according to Klingler's method. To validate our macroscopical findings, 12 samples obtained from the dissected brains and 2 additional specimens from unfrozen brains were prepared for histological examinations. We identified the following white matter connections of the septum verum: (1) the precommissural fibers of the fornix; (2) the inferior fascicle of the septum pellucidum; (3) the cingulum; (4) the medial olfactory stria; (5) the ventral amygdalofugal pathway; (6) the stria medullaris of the thalamus and (7) the stria terminalis. Moreover, we could distinguish a less-known fiber bundle connecting the postcommissural column of the fornix to the stria medullaris of the thalamus and the anterior thalamic nuclei. In this study we present valuable anatomical information about this region to promote safe and effective deep brain stimulation therapies in the future.
A cleaning article made from a substrate such as a woven, nonwoven, or knit fabric. A sanitizer release polymer composition comprising at least one cationic (or alternatively, nonionic) surfactant is bound to the surface of the substrate. Preferably, the cationic surfactant is present in the sanitizer release polymer composition in an amount of about 1 to about 10 weight percent, based on a total weight of the composition. The composition may also include at least one nonionic co-surfactant in combination with the cationic surfactant. The article may also include an indication on its surface to identify a purpose or area of use in which the article is to be utilized. The indication may be a color, an international icon, a tactile label, and/or a label in a plurality of languages identifying the purpose or area where the towel is to be utilized.
Evidence that diabetes self-management education (DSME) can improve health outcomes has repeatedly been shown and is considered to be a critical component of care. Diabetes educators are highly skilled at addressing diabetes-related clinical and behavioral needs through DSME, but engagement with diabetes educators is underutilized. It has been suggested that poor referral practices and the way in which DSME service is delivered are the problems. Most patients receive diabetes care in primary care yet most DSME programs are distinctly separate from primary care practice. This limits care coordination and diabetes educator access to amenities currently available to primary care. Efforts are underway to change the US health care paradigm with a focus on quality in primary care that includes practice redesign, population management, and communication through electronic medical records. The purpose of this application is to evaluate the deployment of Glucose to Goal, a model relying on a systematic redesign of practice that links diabetes educators services with primary care. This will be compared to the traditional process for DSME delivery, without the direct connection to primary care processes, for an eighteen month period. The hypothesis is that the proportion of primary care provider referrals and patient utilization of diabetes educator services from primary care practices participating in Glucose to Goal will be higher compared to those associated with traditional DSME. It is anticipated that this model will appeal to primary care providers, demonstrate a feasible approach to offering diabetes education in the current health environment, and set the stage for future testing of the model, namely its impact on meaningful improvements on diabetes outcomes and cost-effectiveness.
Through complex interactions with the host's immune and physiological systems, gut bacteria play a critical role as etiological agents in a variety of human diseases, having an impact that extends beyond their mere presence and affects the onset, progression, and severity of the disease. Gaining a comprehensive understanding of these microbial interactions is crucial to improving our understanding of disease pathogenesis and creating tailored treatment methods. Correcting microbial imbalances may open new avenues for disease prevention and treatment approaches, according to preliminary data. The gut microbiota exerts an integral part in the pathogenesis of numerous health conditions, including metabolic, neurological, renal, cardiovascular, and gastrointestinal problems as well as COVID-19, according to recent studies. The crucial significance of the microbiome in disease pathogenesis is highlighted by this role, which is comparable to that of hereditary variables. This review investigates the etiological contributions of the gut microbiome to human diseases, its interactions with the host, and the development of prospective therapeutic approaches. To fully harness the benefits of gut microbiome dynamics for improving human health, future research should address existing methodological challenges and deepen our knowledge of microbial interactions.
Compounds, genetic constructs, and cancer treatment methods 035 provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fc&epsiv;-Ϝ transmembrane anchor derived from a subunit of the FC epsilon receptor. mRNA and the IL­2tm fusion protein was expressed in transfected RD995 tumor cells. Expression of the IL­2tm protein on the tumor A511 surface membrane was confirmed by microscopy. RD995 ce11s transfected with IL-2tm or pCMV2b (empty expression vector) were implanted subcutaneously into C3H /HEN mice. Tumors in groups of mice implanted with 106 or 105 RD995 ce11s transfected with IL-2tm grew slower than controls. Without being limited to any one theory, it is believed that selective expression of cytokines such as IL-2 on the surface of tumors is likely to stimulate tumor-infiltrating lymphocytes that are primed and already recognize tumor antigens, enhancing tumor recognition and killing, potentially avoiding toxicity associated with known cytokine therapies.
One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.
The invention discloses an amino acid saturated amnion moisturizing mask and a preparation method thereof. Amnion and chorion of placenta of healthy animals (sheep, goat, deer) are isolated. The amnion is processed into amnion acellular matrix by acellular treatment; the chorion is processed by freeze thawing, crushing, centrifugal separation, etc. to obtain chorion amino acid concentrated solution (amino acid content is greater than or equal to 3.5 mg/ml). Immersing the amniotic membrane acellular matrix in the chorionic amino acid concentrated solution, and carrying out 24 hours at the temperature of 2-8 ℃ to ensure that the amniotic membrane acellular matrix adsorbs chorionic amino acid in a saturated mode to form the amino acid saturated acellular amniotic membrane. And then, adhering the amnion and the mask carrier to obtain the amino acid saturated amnion moisturizing mask. The facial mask disclosed by the invention is natural and green, has no chemical substances added, and has the remarkable functions of moisturizing, increasing skin elasticity, improving skin metabolism and the like.
Assessing fertilized human embryos is crucial for in vitro fertilization, a task being revolutionized by artificial intelligence. Existing models used for embryo quality assessment and ploidy detection could be significantly improved by effectively utilizing time-lapse imaging to identify critical developmental time points for maximizing prediction accuracy. Addressing this, we develop and compare various embryo ploidy status prediction models across distinct embryo development stages. We present BELA, a state-of-the-art ploidy prediction model that surpasses previous image- and video-based models without necessitating input from embryologists. BELA uses multitask learning to predict quality scores that are thereafter used to predict ploidy status. By achieving an area under the receiver operating characteristic curve of 0.76 for discriminating between euploidy and aneuploidy embryos on the Weill Cornell dataset, BELA matches the performance of models trained on embryologists' manual scores. While not a replacement for preimplantation genetic testing for aneuploidy, BELA exemplifies how such models can streamline the embryo evaluation process.
Lysozyme phosphate, glycerophosphate, lactate gluconate and hexametaphosphate are new. They are prepd. by salifying lysozyme with an appropriate acid or a lysozyme salt with sodium salt of the appropriate acid. Prophylactic treatment of chickens involves admin. of lysozyme or its salts. Lysozyme combats vaccination stress in chickens so that the usual antibiotic dosage can be reduced or avoided. It is also useful in treating respiratory diseases. Lysozyme also acts as a growth factor.
A method for treating the recurrent uterine hemorrhage in pubertal girls comprises the use of Tranexam, Oxytocin, Etamzilate, Mefenamic acid, Afobasol, Neurorubin, Regulon, Dufaston, and herbal species. Upon attainment of hemostasis and stabilization of the state of the patient, enteral oxygen therapy, electrically induced sleep, and individual psychotherapy are provided. When the treatment is provided on an outpatient basis, Tranexam, Etamzilate, Afobasol, Regulon, Novinet, Regulon Dufaston, Evika, and herbal species are used. Upon attainment of hemostasis and stabilization of the state of the patient, enteral oxygen therapy, electrically induced sleep, and individual psychotherapy are provided. When the treatment is provided in sanatorium, Tranexam, tamzilate, Mefenamic acid, Afobasol, Regulon, Novinet, Regulon Dufaston, Evika, and herbal species are used. Upon attainment of hemostasis and stabilization of the state of the patient, enteral oxygen therapy, electrically induced sleep, electrophoresis with calcium and sodium bromide, individual psychotherapy, and breathing exercises are provided.
The present invention relates to a medicine 'Yiganjiangmeisan' for treating hepatitis B and a preparation method thereof, which is a pure traditional Chinese medicine preparation mainly used for treating hepatitis B, transaminase raising and icteric index raising. In the prescription, artemisiae scopariae, rhubarb, giant knotweed, scutellaria root and forsythia fruit have the functions of liver protection, transaminase reduction, negative turning promotion, body immunity strengthening, effective hepatitis B resistance, virus prevention, etc.; white peony root, red peony root, rehmannia root, schisandra fruit and ophiopogon root have the functions of blood nourishing, blood stasis dissipation, liver kneading, yin nourishing, fluid promotion, etc.; glossy privet fruit, fleece-flower root and herba ecliptae have the functions of peripheral white cell raising and organism virus-resistant capability strengthening; atractylodes rhizome, aucklandia root, medicated leaven, fructus, calamus and glycyrrhiza have the functions of spleen reinforcing, spleen and stomach strengthening, digestion aid, chest stuffiness relieving, appetite promotion, qi regulation, etc.; kudzu root has the functions of muscles relieving, heat removing, etc.; dahurian angelica root and water plantain have the functions of wind expelling, pain alleviation and abdominal distention elimination; curcuma root and safflower have strong functions of promoting the circulation of qi, removing blood stasis, removing toxicity, improving body immunity, lowering transaminase and promoting negative turning. The clinical application of Dongrong hospital of Shuangyashan city mining group company in Heilongjiang proves that the curative effect is obvious.
The invention discloses a method for synthesizing a tumor combined treatment nano preparation based on mineralized Sendai virus, which is prepared by CaHPO 4 Mineralized Sendai virus and ICG ((ICG + SEV) @ CaHPO) 4 ) The method for synthesizing the photothermal tumor combined treatment nanometer preparation by the strategy biomimetic simulation. The method comprises the following specific steps: 1) preparing an aqueous solution of indocyanine green; 2) one-pot synthesis of (ICG + SEV) @ CaHPO 4 And (3) nanoparticles. Sendai virus (SEV) can activate organism immunity, and kill and eliminate tumor in all directions. ICG has higher photo-thermal conversion efficiency under the irradiation of near-infrared laser,can effectively guide tumor photothermal therapy. In the pathway formed by the calcium ion signal and the tumor cell apoptosis, pro-apoptotic proteases which promote and cause each other exist, so that the tumor cell apoptosis is accelerated. The composite nano-particle integrating virus immunotherapy and photothermal therapy can improve the effect of tumor therapy.
Mild hyperbaric oxygen therapy (mHBOT) is an adjuvant therapy used in conditions where tissue oxygenation is reduced and is implemented using pressures less than 1.5 ATA and 100% O2 (instead of the classical HBOT at 1.9-3 ATA) which results in cheaper, easier to implement, and equally effective. mHBOT is offered for wellness and beauty and as an anti-aging strategy, in spite of the absence of studies on the cardiovascular system. Consequently, we investigated the impact of mHBOT on the cardiovascular system. Mechanical and energetic parameters of isolated heart submitted to ischemia/reperfusion injury and arterial contractile response from mHBOT-exposed rats were evaluated. In the heart, mHBOT increased pre-ischemic velocity of contraction and ischemic end-diastolic pressure and developed pressure and contractile economy during reperfusion. mHBOT decreased infarct size and increased the plasma nitrite levels. In the artery, mHBOT increased acetylcholine sensitivity. mHBOT protects the heart during ischemia/reperfusion and affects vascular relaxation.
Introduction: most studies that analyze the relationship between diet quality and obesity have a cross-sectional design; an alternative with repeated cross-sectional data is a pseudo-panel design. Objective: to estimate the association between trends in dietary patterns, defined by a diet quality index, and body mass index (BMI) of Mexican adults between 2006 and 2016. Methodology: a pseudo-panel analysis was performed using data from cross-sectional surveys: National Health and Nutrition Surveys of Mexico (ENSANUTs) 2006 and 2012 and the Midway National Health and Nutrition Survey 2016 (ENSANUTMC). Cohorts (n = 108) were constructed by grouping adults 20-59 years old by sex (men n = 6,081 and women n = 11,404), education level, and year of birth. The association between diet quality (defined with the Healthy Eating Index-2015) and BMI was estimated using a fixed effects model, adjusting for sociodemographic characteristics. Results: a one-point increase in the proportion of women with high diet quality was associated with 4.1 points lower BMI (p = 0.014) compared with women with low diet quality when excluding sub-reporters of energy, the same association is observed when physical activity is included in the model. No association was found between diet quality and BMI in men, possibly because of the existence of latent classes within sociodemographic strata, therefore diet qualiy is inversely associated with BMI only in some categories of sociodemographic strata. Conclusions: these results contribute to the evidence in the longitudinal analysis between diet and BMI, highlighting the importance of differentiating the population by sex and sociodemographic characteristics. These results are input for public policy creation that promotes improving the quality of the population's diet as part of multisectoral strategies to reduce overweight and obesity in Mexican adults.
BACKGROUND: Adhesive arachnoiditis is a rare yet serious complication that may occur following subarachnoid hemorrhage (SAH). In this circumstance, it is mainly due to ruptured vertebral artery (VA) or posterior inferior artery (PICA) aneurysms. It disrupts cerebrospinal fluid (CSF) flow leading to complications such as spinal arachnoiditis, syringomyelia, trapped 4th ventricle, or a combination of these conditions. Evidence for effective treatment strategies is currently limited. We aimed to review the epidemiology, clinical characteristics, treatment, complications, outcomes, and prognosis of cranio-vertebral junction and spinal adhesive arachnoiditis resulting from ruptured VA and PICA aneurysms.
METHODS: This study involved a comprehensive literature review and complemented by our own case. We focused on adult cases of arachnoiditis, syringomyelia, and trapped 4th ventricle with SAH caused by ruptured VA or PICA aneurysms, excluding cases unrelated to these aneurysms and those with insufficient data.
RESULTS: The study included 22 patients, with a mean age of 52.4 years. Symptoms commonly manifest within the first year after SAH and timely diagnosis requires a high index of suspicion. Treatment approaches included lysis of adhesions and various shunt procedures. Most patients showed improvement post-treatment, though symptom recurrence is significant.
CONCLUSION: Adhesive arachnoiditis is a critical complication following SAH, most commonly from ruptured VA and PICA aneurysms. Early detection and individualized treatment based on the type of arachnoiditis and CSF flow impact are crucial for effective management. This study underscores the need for tailored treatment strategies and further research in this field.
The control group (n=150) will follow their habitual sleeping schedule. Parents will be instructed not to alter their children's daily sleeping routine, or their diet and physical activity habits. The same number and frequency of meetings (in-person or virtual) and methods of registration of bedtime/wake-up times will be used as in the sleep extension group. All sessions for the control group will be educational in nature and will focus on the appropriate use of devices to monitor sleep, and preparation for the assessments.
Patients receive propranolol hydrochloride PO BID beginning 48-72 hours before treatment. Patients undergoing surgery resume propranolol hydrochloride post-operatively once oral drugs are tolerated and continue until completion of 6 cycles of chemotherapy. Patients undergoing neoadjuvant chemotherapy continue propranolol hydrochloride PO BID during 3 chemotherapy cycles pre-surgery and 3 cycles post-surgery. Treatment repeats every 3 weeks for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
The counseling program is 6 sessions, and it is the sessions will last 60-90 minutes on average once a week and be conducted via online video-conference applications. The first session is informing group members about emotional eating and solution-oriented approach, determining members' goals and expectations. Second session; It aims to ensure that emotions are noticed, to clarify the goals with the miracle question technique, and to focus on the solution by getting away from the problems. In the third session; Exception questions focus on recognizing exceptional situations, strengths, and skills. In the fourth session; It is aimed to discuss the existing coping methods of the group members, to recognize the useful coping methods and strengths and to increase their use. In the fifth session; focuses on designing a positive future and steps towards achieving a positive future. In the sixth session, the sessions are summarized by the group leader and members.
BACKGROUND: Observational studies and experimental evidence have shown that chemokines play important roles in lung cancer development, progression, and treatment. However, few studies have examined the causal association between them.
METHODS: Summary data of chemokines and lung cancer were obtained from genome-wide association studies. Mendelian randomization (MR) analyses were performed by five methods, Inverse variance weighted (IVW), Weighted median estimation, MR-Egger, Simple mode and Weighted, with IVW as the primary analysis method. Sensitivity analysis was used to assess the reliability of the MR results. Multivariate Mendelian randomization studies were used to infer whether causality was influenced by potential mediators. The expression levels of CCL21 were analyzed by quantitative real-time PCR.
RESULTS: We found that CCL21 was negatively associated with lung adenocarcinoma risk. CCL25 was positively associated with lung squamous cell carcinoma risk. CCL5 was negatively associated with small cell lung cancer risk. CCL21, CCL24, CCL27, and CCL28 was positively associated with small cell lung cancer risk. After multivariate Mendelian randomization adjustment for smoking behavior, it was found that the effect of CCL25 on lung squamous cell cancer disappeared, and the effect of CCL21 on small cell lung cancer was quite opposite to the univariate. The receiver operating characteristic curve indicated that chemokines had high accuracy in the diagnosis of lung cancer. CCL21 expression levels showed large differences in lung adenocarcinoma cells.
CONCLUSION: These results highlighted the causal effects of chemokines on lung cancer and suggested a mediating role of smoking behavior in the association between chemokines and lung cancer.
OBJECTIVE: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS1 function in hypothalamic neurones, whereas disproportionate metabolic complications may be due to impaired adipose tissue expandability. We tested this by comparing the metabolic effects of global and mesenchymal stem cell (MSC)-specific Alms1 knockout.
METHODS: Global Alms1 knockout (KO) mice were generated by crossing floxed Alms1 and CAG-Cre mice. A Pdgfrα-Cre driver was used to abrogate Alms1 function selectively in MSCs and their descendants, including preadipocytes. We combined metabolic phenotyping of global and Pdgfrα+ Alms1-KO mice on a 45% fat diet with measurements of body composition and food intake, and histological analysis of metabolic tissues.
RESULTS: Assessed on 45% fat diet to promote adipose expansion, global Alms1 KO caused hyperphagia, obesity, insulin resistance, dyslipidaemia, and fatty liver. Pdgfrα-cre driven KO of Alms1 (MSC KO) recapitulated insulin resistance, fatty liver, and dyslipidaemia in both sexes. Other phenotypes were sexually dimorphic: increased fat mass was only present in female Alms1 MSC KO mice. Hyperphagia was not evident in male Alms1 MSC KO mice, but was found in MSC KO females, despite no neuronal Pdgfrα expression.
CONCLUSIONS: Mesenchymal deletion of Alms1 recapitulates metabolic features of AS, including fatty liver. This confirms a key role for Alms1 in the adipose lineage, where its loss is sufficient to cause systemic metabolic effects and damage to remote organs. Hyperphagia in females may depend on Alms1 deficiency in oligodendrocyte precursor cells rather than neurones. AS should be regarded as a forme fruste of lipodystrophy.