anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Prospective, double blind randomized clinical trial of hip fracture patients who will be assessed for CD pre- and postoperatively, using the Mini Mental State Examination (MMSE). The presence of CD will be determined at follow-up evaluation up to three months after surgery. Patients undergoing hip surgery will be randomized into two groups. Group 1 will receive unilateral lumbosacral nerve block (sciatic nerve block and paravertebral block at levels L3-L4 and L4-L5) as well as placebo injection (1 ml normal saline) at the spinal anesthesia level (L3-L4 or L4-L5). The sciatic nerve will be injected by 20 ml of the anesthetic mixture whereas levels L3-L4 and L4-L5 will be injected by a total of 20 ml of the anesthetic mixture without exceeding the maximum injected volume of 1 ml/kg. Group 2 will receive spinal anesthesia (3 ml of 0.5% bupivacaine) in addition to placebo injection at the sciatic, L3-L4 and L4-L5 levels.
PURPOSE: A silicon emulsion composition is provided to be applied to products for hair care such as a shampoo, a rinse, a hair conditioner, and a hair treatment, and to produce a produce with conditioning effects such as excellent luster, coating property, and antistatic property, a cleansing effect, and a hair protection effect. CONSTITUTION: A silicon emulsion composition contains water, a non-ionic surfactant, silicon gum blending oil, and a neutralizing agent. The silicon gum blending oil contains polydimethyl siloxane and amino-modified siloxane. The viscosity of polydimethyl siloxane is 100-20,000,000 cP. A method for preparing the silicone emulsion composition comprises: a step of mixing the silicone gum blending oil and the non-ionic surfactant; a step of adding water and mixing; and a step of adding a neutralizing agent and mixing. A product for hair care contains the silicon emulsion composition.
Chronic exposure to arsenic causes adverse health effects in children. Aberrant epigenetic modifications including altered DNA methylation pattern are one of the major steps towards malignant transformation of cells. Our group has previously identified significant alteration in DNA methylation mark in arsenic exposed adults, affecting major biological pathways. Till date, no information is available exploring the altered DNA methylation mark in telomere regulation and altered mitochondrial functionality in association with DNA damage in arsenic-exposed children. Our study aims in identifying signature epigenetic pattern associated with telomere lengthening, mitochondrial functionality and DNA damage repair in children with special emphasis on DNA methylation. Biological samples (blood and urine) and drinking water were collected from the children aged between 5 and 16 years of arsenic exposed areas (N = 52) of Murshidabad district and unexposed areas (N = 50) of East Midnapur districts, West Bengal, India. Methylation-specific PCR was performed to analyse subtelomeric methylation status and promoter methylation status of target genes. Results revealed altered DNA methylation profile in the exposed children compared to unexposed. Promoter hypermethylation was observed in MLH1 and MSH2 (p < 0.05 and p < 0.001) indicating inefficiency in DNA damage repair. Hypomethylation in mitochondrial D-loop (p < 0.05) and TFAM promoter region (p < 0.05) along with increased mitochondrial DNA copy number among exposed children was also observed. Significant increase in telomere length and region specific subtelomeric hypermethylation (XpYp, p < 0.05) was found. Analysis of S-Adenosyl Methionine (SAM) and 8-oxoDG level revealed significant depletion of SAM (p < 0.001) and elevated oxidative DNA damage (p < 0.001) respectively in arsenic toxicity. Our study identified key methylation patterns in arsenic-exposed children which may act as an early predictive biomarker in the near future. Further in-depth studies involving large sample size and transcriptomic analysis are required for understanding the mechanistic details.
In this group, the mother applied multiple sensory stimuli. In this group, the mothers of the babies to be vaccinated applied multiple sensory stimuli such as breastfeeding, mother's voice, touch-light massage, and eye contact. The mother breastfed her baby for a total of 20 minutes. Breastfeeding was terminated before vaccination. Other applications were applied for 5 minutes before vaccination and 5 minutes after vaccination. FLACC pain scale, SPO2, and pulse oximetry were evaluated and recorded 5 min before and 2 min after vaccination, immediately before vaccination, immediately after vaccination (pain during the procedure), and 2 and 5 min after the procedure.
The study was conducted in Abu Dhabi Stem Cells Center (ADSCC), and the cell processing and investigational product formulation were performed at the same center according to Good Laboratory Practices (GLPs) and Good Manufacturing Practices (GMPs). Participants received the investigational therapy through compressor (jet) nebulization (two doses divided on Days 0 and 1). The primary endpoint was the safety assessment, to be measured as Adverse Reactions (ARs) incidence \[by the World Health Organization - Uppsala Monitoring Centre (WHO-UMC) causality assessment system\], and the nebulization tolerability rate (Days 0 and 1). The Laboratory testing profile was evaluated before treatment (Day 0 or -1) and on Days 14 and 28. Two thorax radiography tests (chest X-rays - CXR) were assessed: before the therapy (Day 0 or -1) and on Day 7. An electrocardiogram (ECG) assessment was performed on Days 0 (or -1), 14, and 28. The application of the validated St. George's Respiratory Questionnaire (SGRQ) on Days 0 and 28 was a surrogate safety endpoint. The whole clinical assessment in SANTANA Study was daily recorded until Day 28, taking into account the ARs incidence. The secondary endpoint was the tolerability assessment, measured by nebulization tolerability rate (Days 0 and 1), and Adverse Events (AEs) tolerability within 28-days. The trial was approved by the ADSCC Research Ethics Committee, and written informed consent was obtained from all participants. SANTANA Study was conducted following the Declaration of Helsinki principles and Good Clinical Practices (GCPs), and the authors are responsible for designing the trial, compiling, and analyzing the data.
Methods, systems, and apparatuses are described for generating an interdental filler model for a patient. Locations for ends of the interdental filler model may be determined. A curvature of the interdental filler model may be determined. A shape of the interdental filler model may be determined. A first arc may be determined for a first end of the interdental filler model and a second arc may be determined for a second end of the interdental filler model. A set of arcs may be interpolated between the first arc and the second arc. The set of arcs may be grounded on the patient's gingiva. The interdental filler model may be generated based on the set of arcs.
Goal 1: How does sleep loss and clinical sleep disruption (i.e. Insomnia Disorder) impact emotion perception and emotion regulation? The investigators are interested in how chronic loss of sleep, either through artificially restricting sleep or clinically related sleep disturbance, impairs our ability to properly perceive and regulate our responses to emotional information using various emotion regulation strategies. There has been research on the effect of sleep loss on broad areas of cognition, such as attention, working memory, and reasoning ability, but the impact of long-term sleep loss on emotional processing and regulation remains largely unexplored. The investigators aim to characterize how sleep loss via experimentally reduced sleep in healthy control participants or clinical sleep disturbance in patients with Insomnia Disorder, affects the ability to accurately perceive emotion. Investigators will also investigate how it alters the intensity with which emotions are perceived, and the effect that these changes have on the ability to regulate emotional responses to these stimuli compared to healthy control participants that are allowed undisturbed sleep.

Goal 2: How are changes in subjective emotional responses reflected in the neural signal and psychophysiological measures? The investigators will utilize fMRI and measures of autonomic reactivity (heart rate and skin conductance) to characterize the neural and psychophysiological responses that are associated with behavioral changes following sleep restriction or in patients with Insomnia disorder compared to healthy sleep control participants.
NEW MATERIAL:A neutral saccharide-containing luteinizing hormone which contains more than 30% of neutral saccharide chain components in the saccharide chain component composition of the beta-subunit. USE:kidney growth promoter. PREPARATION:For example, swine hypophysis is homogenized together with 0.15M aqueous ammonium sulfate and phenylmethylsulfonyl fluoride, adjusted in its pH to 4.0, centrifuged to collect the supernatant. Then, the pH of the supernatant is adjusted to 6.5-7.0, and ammonium sulfate is added to the supernatant to form precipitate. The precipitate is collected and suspended in a buffer, transferred into a dialysis tube to effect dialysis, then freeze-dried. The dried powder is dissolved in a carbonate buffer solution and fractionated by passing through a molecular sieve column to collect the fractions of about 40,000 molecular weight. The fraction is further fractionated using a Con A- immobilized column, the adsorbate is eluted and purified by the isoelectric electrophoresis to obtain the subject kidney growth promoting factor.
FIELD: medicine. ^ SUBSTANCE: invention relates to field of veterinary. Method lies in application of preparation which conbtains ivermectin, triethylene glycol and propolis with the following component ratio, wt %: ivermectin - 0.01, propolis - 5-6, triethylene glycol - 93.99-94.99. Medication is used by aerosol propellent or non-propellent type of dispersion or direct application into conjunctival sac of animal one time in dose 0.5-1.0 ml into each affected eye. ^ EFFECT: method makes it possible to obtain high therapeutic effect, possesses anti-inflammatory action, contributes to acceleration of regeneration of damaged eye tissues. ^ 5 ex
The invention discloses a corynespora viticola, a traditional Chinese medicine microecological preparation for preventing and treating ruminant diarrhea and a preparation method thereof. The corynespora viticola (Clavispora lusitaniae) has a strain name of SAMY-9G; the culture is preserved in China Center for Type Culture Collection (CCTCC) No. M20221520. The strain is derived from ruminants, has the characteristic of high temperature resistance, and is more beneficial to propagation and probiotic effect in the rumen environment of the ruminants. The traditional Chinese medicine microecological preparation is obtained by inoculating microorganism composite fermentation seed liquid into a fermentation culture medium which takes traditional Chinese medicine compounds consisting of dark plum, chinese pulsatilla root, purslane, chinese gall, antifebrile dichroa and astragalus as substrates for fermentation, wherein the effective viable count is 10.0-20.0x10  8  cfu/mL. The preparation has better curative effect on bacterial, viral, parasitic and stress induced ruminant comprehensive diarrhea than single antibiotic for treating bacterial diarrhea, and greatly reduces the dosage of traditional Chinese medicine, and can improve the growth performance, antioxidant capacity and immunity of host animals.
Synaptic dysfunction and loss are central to neurodegenerative diseases and correlate with cognitive decline. Synaptic Vesicle Protein 2A (SV2A) is a promising PET-imaging target for assessing synaptic density in vivo, but comprehensive mapping in the human brain is needed to validate its biomarker potential. This study used quantitative immunohistochemistry and Western blotting to map SV2A and synaptophysin (SYP) densities across six cortical regions in healthy controls and patients with early-onset Alzheimer's disease (EOAD), late-onset Alzheimer's disease (LOAD), progressive supranuclear palsy (PSP), and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-GRN). We identified region in SV2A density among controls and observed disease- and region-specific reductions, with the most severe in FTLD-GRN (up to 59.5%) and EOAD. EOAD showed a 49% reduction in the middle frontal gyrus (MFG), while LOAD had over 30% declines in the inferior frontal gyrus (IFG) and hippocampus (CA1). In PSP, smaller but significant reductions were noted in the hippocampal formation, with the inferior temporal gyrus (ITG) relatively unaffected. A strong positive correlation between SV2A and SYP densities confirmed SV2A's reliability as a synaptic integrity marker. This study supports the use of SV2A PET imaging for early diagnosis and monitoring of neurodegenerative diseases, providing essential data for interpreting in vivo PET results. Further research should explore SV2A as a therapeutic target and validate these findings in larger, longitudinal studies.
Background: Children born to parents with severe mental illness like schizophrenia, bipolar disorder or major recurrent depression have an increased risk of developing a mental illness themselves during life. These children are also more likely to display developmental delays, cognitive disabilities, social problems and may have a higher risk than background population of experiencing adverse life events. This is due to both genetic and environmental factors, but in spite of the well documented increased risk for children with familial high risk no family-based early intervention has been developed. This study aims to investigate the effect of an early intervention model focusing on reducing risk and increasing resilience for children in families where at least one parent has a severe mental illness.

Methods: The study is a randomized clinical trial including 100 children age 6-12 with familial high risk. Families will be recruited from registers or be referred from the primary sector or from hospitals. The children and their parents will be assessed at baseline and thereafter randomized and allocated to either Treatment as Usual or VIA Family. In the VIA Family group the families will be offered regular contact with a case manager. A multidisciplinary team of specialists from Adult Mental Health Services, Child and Adolescent Mental Health Services and Social Services will be responsible for providing the basic treatment elements that are: case management, psychoeducation for the whole family, parental training (Triple P) and early intervention for mental problems of the child. The study period is 18 months for both groups and all participants will be assessed at baseline and after 18 months. Primary outcome measure will be daily functioning of the child (CGAS), and secondary measures are psychopathology in the child and days of school absence, family functioning and child's home environment.

Discussion: This study is to the investigators knowledge the first to explore the effects on children with familial high risk for severe mental illness of a multidisciplinary team intervention providing an intensive and flexible support matching the families' needs. The study will provide important knowledge about the possibilities of increasing resilience and reducing risk of a child by supporting the whole family. However, longer follow-up time may be needed.
The radioactive stent carrying seeds iodine 125 is made of Polytetrafluoroethylene. It will be implanted in the common bile duct by ERCP(endoscopic retrograde cholangiopancreatography) of the irradiation group patients.
A computer method to improve medical outcomes that receives at a backend server notification of surgery including a recovery location. Creating a plan to deliver a smart treatment device with a unique identifier to the recovery location. Associate the unique identifier to the surgery. Receiving information that the smart treatment device is at the recovery location. The smart treatment device gathers recovery data. Sending the recovery data with the unique identifier to the backend server. Receiving at the backend server the recovery data. Receiving a request for access to the recovery data for the surgery. Providing access to the recovery data. Receiving and implementing adjustments to a treatment plan. Receiving final medical outcome information. Recording the surgery, recovery data and final medical outcome in a historical database. Training a machine learning algorithm on the historical data. Using the machine learning algorithm to suggest adjustments the treatment plan.
BACKGROUND/AIMS: : Endoscopic papillectomy (EP) is increasingly used as an alternative to surgery for managing benign ampullary neoplasms. However, post-EP resection margins are often positive or indeterminate, and there is no consensus on the management of ampullary adenomas with positive or indeterminate margins after EP. This study was designed to compare the long-term outcomes between resected margin-negative (RMN) and resected margin-positive/indeterminate (RMPI) groups and to identify factors associated with clinical outcomes.
METHODS: : This retrospective analysis included patients with ampullary adenoma without evidence of adenocarcinoma who underwent EP between 2004 and 2016. The RMN and RMPI groups were compared for recurrence rates and recurrence-free duration during a mean follow-up duration of 71.7±39.8 months. Factors related to clinical outcomes were identified using multivariate analysis.
RESULTS: : Of the 129 patients who underwent EP, 82 were in the RMN group and 47 were in the RMPI group. The RMPI group exhibited a higher recurrence rate compared to the RMN group (14.6% vs 34.0%, p=0.019). However, the recurrence-free duration was not significantly different between the groups (34.7±32.6 months vs 36.2±27.4 months, p=0.900). Endoscopic treatment successfully managed recurrence in both groups (75% vs 75%). Submucosal injection was a significant risk factor for residual lesions (hazard ratio, 4.11; p=0.009) and recurrence (hazard ratio, 2.57; p=0.021).
CONCLUSIONS: : Although ampullary adenomas with positive or indeterminate margins after EP showed a higher rate of recurrence at long-term follow-up, endoscopic treatment was effective with favorable long-term outcomes. Submucosal injection prior to resection was associated with increased risk of recurrence and residual lesions.
The present invention relates to novel antibodies, antibody fragments and antibody conjugates and single-chain immunotoxins reactive with human carcinoma cells. More particularly, the antibodies, conjugates and single-chain immunotoxins of the invention include: a murine monoclonal antibody, BR96; a human/murine chimeric antibody, ChiBR96; a F(ab')2 fragment of BR96; ChiBR96-PE, ChiBR96-LysPE40, ChiBR96 F(ab')2-LysPE40 and ChiBR96 Fab'-LysPE40 conjugates and recombinant BR96 sFv-PE40 immunotoxin. These molecules are reactive with a cell membrane antigen on the surface of human carcinomas. The BR96 antibody and its functional equivalents, displays a high degree of selectivity for carcinoma cells and possess the ability to mediate antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity activity. In addition, the antibodies of the invention internalize within the carcinoma cells to which they bind and are therefore particularly useful for therapeutic applications, for example, as the antibody component of antibody-drug or antibody-toxin conjugates. The antibodies also have a unique feature in that they are cytotoxic when used in the unmodified form, at specified concentrations.
There is provided a method of forming a segmented composition utilizing the thermal exchange properties of a first component that solidifies when cooled, and a second component that solidifies when heated. When an amount of the heat from the first component is transferred to the coolness of the second component, and vice versa, both the first and second components are provided with structural integrity, this forming the segmented composition. There is also provided a method and an apparatus that can form a segmented cosmetic composition. The segmented cosmetic composition has at least two components. A first component is preferably a molten wax. A second component is preferably a smectite clay dispersion. One of the components fully surrounds, partially surrounds, or is adjacent to the other component. Figure 1 shows a rod 3 which is inserted into the cavity 4 to form a core. The molten wax-based component 5 is then poured into the cavity 4 and allowed tu partially 'set up'. As is known by those skilled in the art, the term 'set up' means that the composition begins to solidify as its temperature approaches room temperature. Thereafter, the rod 3 is removed.
A medication reminder and dispensing device includes a housing having at least one opening and at least one drawer containing at least one dose of a medication to be delivered to a patient. The drawer is slidably positioned in the opening and configured to move from a closed position to an open position. The device also includes at least one electromagnet connected to the housing or drawer configured to be transitioned between a first state and a second state. When in the first state, the electromagnet is configured to maintain the drawer in the closed position. When in the second state, the drawer automatically moves to the open position. The device also includes a processor configured to cause the at least one electromagnet to transition from the first state to the second state based on the pre-programmed schedule, thereby causing the drawer to automatically move to the open position.
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes the novel tetralone or benzopyranone derivatives and method of their synthesis that can be used as therapeutic drug for prophylaxis and treatment of patients with hormone-depending diseases. New tetralone and benzopyranone derivatives have the general formula (I)   where each of R 1  and R 2  means hydrogen atom, hydroxyl-group, alkoxy-group, respectively; each of R 3 -R 7  means hydrogen atom, hydroxyl-group, direct or branched alkyl, alkylhydroxy-group containing 1-6 carbon atoms, halogen atom, amino-group or alkylenedihydroxy-group bound respectively by the point R 3  and R 4 , R 4  and R 5 , R 5  and R 6  or R 6  and R 7  and A means methylene-group or oxygen atom. Compounds show inhibiting effect on activity of 17-17β-hydroxysteroid dehydrogenase and therefore these derivatives can be used for preparing therapeutic agent used for prophylaxis and/or treatment of patients with androgen- and estrogen-dependent diseases, in part, prostate gland cancer, prostate benign hyperplasia, virilism. breast cancer, mastopathy, uterus cancer, ovary cancer and so on. EFFECT: improved method of synthesis, enhanced anticancer activity of compounds. 4 cl, 3 dwg
The invention embeds SAT2 in Loop2 region on the surface of PPV VP2 protein based on the simulation result of computer softwareFMDV B cell epitopes (VYTKAAAAIRGDRAALAAKYADTNHTLPPTFNFGYVTVD). The chimeric gene GS1921OP is synthesized according to insect cell tropism optimization and cloned to a vector pFastBac TM On Dual, transformation of competent cell DH10Bac to obtain recombinant bacmid L 2 B, transfecting sf9 cells to obtain recombinant baculovirus rBacL 2 B. Detection of the chimeric epitope and the VP2 protein using indirect immunofluorescence was specific for fluorescence. West ern Blot was tested against the chimeric epitope and VP2 protein, and a specific band appeared at 67 kDa. Recombinant chimeric protein L 2 B is capable of self-assembly into Virus-like Particles (VLPs). The invention can be applied to the preparation of the reserve vaccine for the south Africa type 2 foot-and-mouth disease and can achieve the purpose of preventing the south Africa type 2 foot-and-mouth disease and the porcine parvovirus disease simultaneously on the basis.