anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Facial fractures and their historical link to potential blindness have been well-documented, often attributed to optic canal injuries or retinal vascular occlusion. This dire consequence can result from both direct and indirect ocular trauma, including retrobulbar hemorrhage. Traumatic orbital compression can manifest in various forms, such as hematomas, fractured bone fragments, and emphysema, all posing a significant threat to vision, necessitating immediate intervention. In this study, 9 clinical cases of traumatic orbital compression are presented, each characterized by distinct etiologies. The study delves into traumatic orbital compressive syndromes, underscoring the critical imperative of early recognition and treatment to prevent vision loss. Orbital compression, whether from edema, hematoma, or emphysema, collectively culminates in elevated intraorbital pressure and the potential for optic nerve ischemia. Through the presentation of these 9 clinical cases, the article emphasizes the pressing need for timely intervention in addressing orbital compressive syndromes to avert vision loss. Various surgical techniques are elucidated, highlighting the pivotal role of expeditious medical intervention. This article offers invaluable insights into the diagnosis, management, and outcomes of traumatic orbital compressive syndromes.
The invention discloses a traditional Chinese medicine composition for preventing and/or treating adverse reactions related to tumor immunotherapy and a preparation method thereof. The composition comprises the following traditional Chinese medicinal materials in parts by mass: 1-60 parts of Chinese yam, 1-60 parts of angelica, 1-30 parts of white peony root, 1-60 parts of radix rehmanniae, 1-10 parts of safflower, 1-30 parts of adenophora trachelioides and 1-30 parts of radix ophiopogonis. The preparation method is to prepare any clinically acceptable preparation according to the prior art. Such as decoction, granule, pill or capsule. The traditional Chinese medicine composition has the effects of tonifying qi, nourishing yin, nourishing blood, removing stagnation and detoxifying. Pharmacodynamic tests prove that the traditional Chinese medicine composition has good effects of preventing and treating inflammatory side effects of various organs caused by tumor immunotherapy, and prolongs the immunotherapy tolerance period, thereby enhancing the anti-tumor effect and improving the prognosis. And has remarkable effects on adjusting and recovering physiological functions of viscera, improving symptoms, improving the life quality of patients and the like. Simple and cheap, and no obvious toxic side effect.
FIELD: medicine. SUBSTANCE: ointment of ozonized vegetable oil is applied on injury areas. Said oils are prepared by treatment vegetable oils with ozone till peroxide number is 200-700 (as calculated for ozonides). Said application is prepared in each 6-24 h, treatment course being 14-20 days. Method is available for patients having thrombophlebitis, varicosis, neurology injuries, etc. Thus prepared ointment is intoxic. EFFECT: improves efficiency of the method.
UNLABELLED: CX3CR1+ cells play a crucial role in liver fibrosis progression. However, changes in the migratory behavior and spatial distribution of spleen-derived and hepatic CX3CR1+ cells in the fibrotic liver as well as their influence on the liver fibrosis remain unclear.
METHODS: The CX3CR1GFP/+ transgenic mice and CX3CR1-KikGR transgenic mice were used to establish the CCl4-induced liver fibrosis model. Splenectomy, adoptive transfusion of splenocytes, in vivo photoconversion of splenic CX3CR1+ cells and intravital imaging were performed to study the spatial distribution, migration and movement behavior, and regulatory function of CX3CR1+ cells in liver fibrosis.
RESULTS: Intravital imaging revealed that the CX3CR1GFP cells accumulated into the fibrotic liver and tended to accumulate towards the central vein (CV) in the hepatic lobules. Two subtypes of hepatic CX3CR1+ cells existed in the fibrotic liver. The first subtype was the interacting CX3CR1GFP cells, most of which were observed to distribute in the liver parenchyma and had a higher process velocity; the second subtype was mobile CX3CR1GFP cells, most of which were present in the hepatic vessels with a faster moving speed. Splenectomy ameliorated liver fibrosis and decreased the number of CX3CR1+ cells in the fibrotic liver. Moreover, splenectomy rearranged CX3CR1GFP cells to the boundary of the hepatic lobule, reduced the process velocity of interacting CX3CR1GFP cells and decreased the number and mobility of mobile CX3CR1GFP cells in the fibrotic liver. Transfusion of spleen-derived classical monocytes increased the process velocity and mobility of hepatic endogenous CX3CR1GFP cells and facilitated liver fibrosis progression via the production of proinflammatory and profibrotic cytokines. The photoconverted splenic CX3CR1+ KikRed+ cells were observed to leave the spleen, accumulate into the fibrotic liver and contact with hepatic CX3CR1+ KikGreen+ cells during hepatic fibrosis.
CONCLUSION: The splenic CX3CR1+ monocytes with classical phenotype migrated from the spleen to the fibrotic liver, modifying the migratory behavior of hepatic endogenous CX3CR1GFP cells and exacerbating liver fibrosis via the secretion of cytokines. This study reveals that splenic CX3CR1+ classical monocytes are a key driver of liver fibrosis via the spleen-liver axis and may be potential candidate targets for the treatment of chronic liver fibrosis.
PURPOSE:To obtain a cleaning agent compsn. being mild to the skins and having fine and good foam quality, excellent cleaning power and excellent touch after cleaning by compounding an amphoteric surfactant with a specified polyethyleneimine polymer. CONSTITUTION:A copolymer (A) with repeating units of formulas I and II (wherein R<1> is H, CH3 or C2H5; R<2> is a 4-15C alkyl, aryl or aralkyl) in a wt. ratio of formula I to formula II of 9/1 to 1/9 (polyethyleneimine polymer) and an amphoteric surfactant (B) (e.g. laurylaminopropionic acid) are compounded. Even though the amphoteric surfactant is mild to the skin and has good foaming properties, it exhibits coarse foam quality and insufficient cleaning power to sebum and oils. It is possible by the abovedescribed combination to obtain a cleaning agent compsn. with fine foam, high cleaning power and good touch after cleaning.
NEW MATERIAL:The compound of formula I (R1 is di- or monoalkylaminocarbonylalkyl, carbamoylalkyl, etc.; R2 is H or lower alkoxy). EXAMPLE:1-Ethoxycarbonylmethyl-4-[4-( 1,2,3,4-tetrahydro-1-naphthoyloxy )-benzoyl]piperazine. USE:It has chymotrypsin-inhibiting activity and is useful as a remedy for pancreatic diseases, etc. PROCESS:The compound of formula I can be obtained by esterifying the 4-substituted phenol of formula II with the tetrahydronaphthyl-carboxylic acid of formula III. The esterification can be carried out, e.g. by reacting the reactive derivative of the compound of formula III (e.g. acid halide acid anhydride, etc.) with the compound of formula II or by reacting the compound of formula IIwith the compound of formula III in the presence of a dehydrating agent such as DCC.
For many years overnight fasting of rats before the collection of clinical pathology blood samples and necropsy has been a common procedure in toxicological studies for regulatory purposes. The fasting was thought to minimize the intragroup variability for clinical pathology and organ weights. However, depriving rats of food overnight will impact animal welfare by interfering with the general metabolism and may result in physiological and behavioural changes. The effects of overnight fasting in comparison to rats that were not fasted prior to necropsy was investigated in lactating rats based on an evaluation of organ weights, haematological, and clinical biochemical parameters. The results of 92 OECD 422 studies were analysed (i.e., Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test) of which approximately half of the studies incorporated fasting prior to necropsy and the other half did not. Terminal body and organ weights from all 92 studies were evaluated. Clinical pathology was included in 78 of these 92 studies. Decreased glucose levels following fasting had been reported in the literature but were not observed when comparing 39 studies with fasted conditions versus 39 studies with non-fasted conditions. Both literature and the analysed database exhibited a reduction in liver weight, alanine aminotransferase, and alkaline phosphatase levels in overnight fasted groups. These differences between fasted and non-fasted states are considered of little account as study results are always interpreted based on the differences in parameter values between treated animals compared to control animals within a study. Contrarily to previously suggested, intragroup variability was lower in the majority of parameters in non-fasted animals. According to laboratory historical data, clinical pathology and organ weight parameters are found to be very similar in male and female rats, indicating that the results of this study may be extrapolatable to non-lactating female and male rats. Based on these comparisons, it is recommended not to fast rats prior to necropsy but to continue feeding all rats ad libitum, to minimize physiological changes in these animals, to reduce variability, improve animal welfare and thereby improve the scientific value of study results.
Patients with an inflammatory joint disease on stable DMARD treatment weith indication of intraarticular glucocorticoid injection. Women should be premenopausal and men younger than 50 years.
Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV. Long non-coding RNAs (lncRNAs), as important epigenetic regulators, have an unclear role in cccDNA transcription regulation. In this study, lncRNA sequencing (lncRNA seq) is conducted on five pairs of HBV-positive and HBV-negative liver tissue. Through analysis, HOXA-AS2 (HOXA cluster antisense RNA 2) is identified as a significantly upregulated lncRNA in HBV-infected livers. Further experiments demonstrate that HBV DNA polymerase (DNA pol) induces HOXA-AS2 after establishing persistent high-level HBV replication. Functional studies reveal that HOXA-AS2 physically binds to cccDNA and significantly inhibits its transcription. Mechanistically, HOXA-AS2 recruits the MTA1-HDAC1/2 deacetylase complex to cccDNA minichromosome by physically interacting with metastasis associated 1 (MTA1) subunit, resulting in reduced acetylation of histone H3 at lysine 9 (H3K9ac) and lysine 27 (H3K27ac) associated with cccDNA and subsequently suppressing cccDNA transcription. Altogether, the study reveals a mechanism to self-limit HBV replication, wherein the upregulation of lncRNA HOXA-AS2, induced by HBV DNA pol, can epigenetically suppress cccDNA transcription.
1421488 Making carrier-bonded polypeptides by irradiation; modified acrylamide copolymers ROHM GmbH 21 Dec 1973 [23 Dec 1972] 59522/73 Headings C3H and C3P A process for the preparation of carrierbonded polypeptides, for example an enzyme, antibody, hormone or enzyme inhibitor comprises irradiating in an essentially oxygen-free atmosphere an aqueous solution of a polypeptide containing a non-peptidic macromolecular reactive carrier, the said solution being irradiated with UV or visible light in the presence of an organic peroxide. The carrier may be a water soluble, water-swellable or water insoluble macromolecular compound preferably containing carboxylic amide, ester, lactone stemiacetal and/or cyclic ether groups and may be a polysaccharide, e.g. a dextran gel, agarose gel or cellulose, vinyl pyrrolidone or may comprise units of methacrylamide, acrylic or methacrylic acid or water-soluble salts thereof, a hydroxyalkyl ester of acrylic or methacrylic acid, 1,2 or 1,4-butanediol acrylate, or methacrylate, an aminoalkyl ester or aminoalkyl amide of acrylic or methacrylic acid or a quaternization product thereof, or units of divinyl benzene, glycol diacrylate or dimethacrylate, triallyl cyanurate, and may comprise side alkenyl and/or alkylphenyl groups. The irradiation may be performed in the presence, as sensitizer, of propiophenone, xanthene, acetophenone, triacetylbenzene, isobutyrophenone, diphenylpropanone benzaldehyde, triphenylmethyl ketone, carbazole, diphenylene oxide, triphenylamine, dibenzothiophene, o-dibenzoylbenzene, benzophenone, dichlorobenzophenone, diacetylbenzene or flucrene. In Example 8, an acrylamide/2-hydroxyethyl methacrylate copolymer is modified by reaction with p-toluene sulphonyl chloride. In Example 9, a similar copolymer is modified by reaction with 4-methylphenylacetic acid chloride.
Acute respiratory distress syndrome (ARDS) is presented as acute hypoxemia and pulmonary edema due to the increased permeability of alveolar capillaries. Endothelial damage injury and swelling, microthrombosis, and hypoxic pulmonary vasoconstriction can lead to low pulmonary blood vessels perfusion and even occlusion, while patients with ARDS often suffer a gravity-dependent alveolar collapse, resulting in a reduction of tidal volume, residual alveolar excessive distension, and ventilator-related lung injury(VILI) induced by unreasonable ventilator setting.Prone ventilation (PPV) improves the gravity-dependent alveolar ventilation and promotes lung recruitment in the gravity-dependent area and improves lung compliance. Besides, pulmonary blood perfusion is less affected by gravity distribution, thus the improvement of gravity-dependent alveolar ventilation can significantly reduce shunt, and lung heterogeneity and improve V/Q radio. Previous studies showed that prolonged PPV combined with low tidal volume lung protected ventilation can significantly reduce the mortality of patients with moderate to severe ARDS.Although more than 60% of patients with moderate to severe ARDS due to COVID-19 has been widely implemented PPV,studies showed an improvement in oxygenation in patients with ARDS(the P/F radio improved by more than 20% before and after PPV) was 9-77%, that is, That is, some patients are unresponsive to PPV. In addition, some patients showed CO2 responsiveness after PPV (ventilation rate (VR) decreased significantly after PPV).The tools for monitoring the effects of PPV on ventilation and blood flow at bedside are still lacking, Electrical impedance tomography (EIT) is a non-invasive, non-radiative, real-time bedside lung imaging technique that can monitor local lung ventilation distribution. By injecting hypertonic saline through a central vein catheter, we can obtain lung perfusion images to indicate local lung blood flow distribution. In addition, combined with lung ventilation images, we can evaluate the pulmonary shunt, dead space, V/Q ratio, to better clarify the physiological and pathological status of lung.This study intends to use EIT to evaluate pulmonary ventilation, blood flow distribution and local V/Q ratio before and after PPV, as well as to monitor the changes in pulmonary physiology before and after PPV, explore the mechanism of PPV improving oxygenation by combined with the changes in oxygenation, and explore the factors that predict and affect PPV responsiveness.
BACKGROUND: Postoperative quality of recovery (QoR) and patient satisfaction have gained increasing significance in medical services. This study aimed to compare these 2 parameters between 2 types of regional anesthetics (spinal anesthesia and combined sciatic-femoral nerve block) in orthopedic lower knee surgery.
METHODS: A total of 101 patients were classified into 2 groups (combined sciatic-femoral nerve block, group N; spinal anesthesia, group S) according to patient preference. In group N, sciatic and femoral nerve blocks were performed on the popliteal and groin regions, respectively, under ultrasound guidance. Spinal anesthesia was performed in group S. The primary outcomes were QoR and patient satisfaction. QoR was measured using the Korean translation of the QoR-15K. Patient satisfaction was assessed using an 11-point Likert scale (0-10) and a dichotomous question addressing anesthesia preferences for future surgeries.
RESULTS: The physical independence of the postoperative QoR-15K was significantly higher in group N than in group S (14.2 vs 12.0, P = .04). On the 11-point Likert scale, group N scored 8.8, and group S scored 7.8 (P = .001). In the dichotomous question, 93.8% of the group N and 52.8% of the group S answered that they would like to choose the same anesthesia method for the next surgery (P < .001). In addition, fewer participants in group N complained of backache than those in group S, and the time to first urination after anesthesia was shorter in group N than in group S (P = .004, <.001, respectively).
CONCLUSION: Combined sciatic-femoral nerve block may provide better physical independence and satisfaction than spinal anesthesia in orthopedic below-knee surgeries.
Burnout threatens the sustainability of compassionate care in rehabilitation. This project explores the impact of an online compassion-based intervention on burnout among specialist inpatient rehabilitation healthcare providers. Thirty specialist rehabilitation healthcare providers will be recruited to take part. The online intervention will include six weekly live one-hour sessions. Healthcare provider socio-demographic, practice, and wellness measures will be collected at baseline, post-course, and three months later. Qualitative interviews will be used to explore participant views on burnout and compassion, experiences with the intervention, barriers and facilitators to taking part, and suggestions for improving online course delivery. Up to two instructors and support persons will be invited to participate in qualitative interviews to explore their views for improving online course delivery.
The present invention includes the selection of a particular species of  Epilobium,  and the production of an efficacious  Epilobium  extract. The method of extraction utilized in the present invention includes the selection and separation of parts of  Epilobium Parviflorum  plant to be used, excluding the use of solid stems and roots. Once selected, the plant parts are combined with a solvent and water for the extraction process. In one embodiment of the present invention, the  Epilobium  plant parts are combined at room temperature, such as between 71 to 81 degrees (F.) or 20 to 25 degrees (C.), with 196 proof Sugar Cane Alcohol (without denaturalization process), stirred, and allowed to rest, such as for 72 hours. Next, an additional amount of Sugar Cane Alcohol and water is added, stirred, and allowed to rest, such as for 24 hours. Next, water is added, stirred, and allowed to rest, such as for 48 hours; and this step may be repeated. Next, additional sugar cane alcohol is added for stabilization, and the mixture is allowed to rest, such as for 96 hours. The mixture is then filtered.
BACKGROUND: The objective of this study was to observe the incidence and potential risk factors of postoperative depression and anxiety in patients during the early period after undergoing orthognathic surgery.
METHODS: From March 7 to September 7, 2023, patients ≥ 18 years of age who were scheduled for elective orthognathic surgery under general anesthesia in Peking University School and Hospital of Stomatology were included in this study. We prospectively evaluated their degrees of pre- and postoperative depression and anxiety using the Patient Health Questionnaire-9 and the State Trait Anxiety Inventory. Associations between the perioperative factors and occurrences of postoperative anxiety and depression were evaluated using a multivariate logistic regression model.
RESULTS: A total of 371 patients were included in the analysis. Within five days after surgery, we observed the occurrence of depression in 32% (116) of the patients and anxiety in 72.8% (270) of them. Their preoperative depression score on the Pain Catastrophizing Scale and intraoperative urine output were significantly associated with a higher risk of postoperative depression. The presence of preoperative anxiety, postoperative moderate-to-severe pain, postoperative nausea and vomiting and postoperative insomnia were significantly associated with a higher risk of postoperative anxiety. Furthermore, a monthly income ≥ ¥10000 was found to be significantly associated with a lower risk of postoperative anxiety.
CONCLUSIONS: Postoperative depression and anxiety are common among patients who undergo orthognathic surgery. Moreover, preoperative psychological status and incidence of postoperative adverse events were associated with an increased risk of depression and anxiety after surgery. The results of the present study suggest that careful psychological assessment and appropriate management are necessary to improve patients' recovery following orthognathic surgery.
FIELD: medical engineering. SUBSTANCE: device has compress sheets covered with medicinal preparations sticking to skin for healing injured part of patient body. Thin film is attached to the lower surface of the compress sheets. The thin film is detachable from the compress sheets when using the plaster. Bearing sheet is in the upper surface of the compress sheets. A pair of conducting layers is attached to the lower surface of the bearing sheet being opposite to the upper surfaces of the compress sheets. Low frequency oscillator is set between the conducting layers. Button for sending a trigger signal to the low frequency oscillator is mounted above the low frequency oscillator. Body temperature pickup or shock-sensitive gauge for sending a trigger signal to the low frequency oscillator is mounted on the inferior surface of the low frequency oscillator. EFFECT: enhanced effectiveness of treatment; increased drug infiltration into injured tissues. 11 cl, 7 dwg
The FDA recently approved the use of COVID-19 booster vaccines for both homologous and heterologous vaccine booster regimens, with both regimens considered standard of care. However, there is incomplete research on the long-term effects and immunity offered by each approach. In fact, the FDA has not offered guidance on whether or not to mix or match vaccines because as of yet, there is no evidence indicating that one strategy should be recommended over the other. Studies have shown that vaccine efficacy declines over time, and the Delta and Omicron variants continue to cause breakthrough cases. Additionally, millions of Americans are now becoming eligible for a booster. These factors present both a pressing need and a unique opportunity to investigate the longitudinal effects of the mixing and matching vaccine-booster approaches.

This study proposes to fill this critical gap through a systematic and prospective randomized trial utilizing the existing digital infrastructure of the COVID-19 Citizen Science (CCS) study on the Eureka Research Platform. Eligible CCS participants will have the opportunity to be randomly assigned to be encouraged to receive either the BNT162b2 (Pfizer) or mRNA-1273 (Moderna) booster vaccine and will continue to complete their weekly CCS follow up surveys on symptoms and infection. Thus, this study will allow for longitudinal follow up of participants receiving homologous and heterologous vaccine booster regimens. By randomizing participants and analyzing a larger cohort, this study aims to mitigate the effect of confounding variables and provide more conclusive evidence to guide booster recommendations.
Subjects aged between and including 18-25 years, who received one dose of Cervarix™ vaccine Lot 3 manufactured at 600L scale according to a 0, 1, 6- month schedule and were followed up for 7 months after the first dose. Additionally, a telephone contact was foreseen at Month 12. The vaccine was administrated by intramuscular (IM) injection into the deltoid region of the non-dominant arm.