anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Exercise is recommended for the treatment for knee osteoarthritis (OA) with muscle strength and aerobic exercise improving physical function. There is evidence supporting quadriceps strength for patients with painful knee OA; positive effects on pain; and general fitness.

Research reviews by suggest exercise as an important aspect of rehabilitation in knee OA. However, there is very limited evidence to what type of exercises actually decrease pain and improve activity.

Despite positive evidence regarding exercise, highlighted major issues within the United Kingdom with only 5% of people with knee OA achieving the recommended level of activity and 57% of the population not completing regular exercise. 1% to 4% of total healthcare costs account for physical inactivity which cost 8.3 billion in 2009.

An essential factor of physical inactivity is exercise behaviour. Fear of movement is an important aspect of knee OA. Disability is present due to the individual's fear of physical movements that would cause pain. Evidence links fear of movement with knee OA and the role of exercise in the management of knee OA. Patients with OA experience pain during activity, which leads to an expectation that further activity, will cause greater pain therefore increasing muscle weakness. It has been indicated that individuals could have negative attitudes and beliefs about their knee problems, which could cause a barrier to treatment, with socioeconomic, personality and environmental factors being as important as the physical characteristics. Other factors such as balance issues and laxity of the knee have been associated with activity limitations. However, in a systematic review found weak evidence to support pain, distress, and avoidance of activity in participants with knee OA. Understanding individual exercise behaviours and habits is essential to improve exercise adherence. Non-compliance is common within physiotherapy with patients unwilling to accommodate exercises within everyday life. Reasons for this may include type of exercises, dosage, and underlying beliefs from the clinicians towards exercise as well as external factors. Incorrect prescription of exercises can lead to increased pain, decreased function and decreased exercise adherence. This could cause fear of movement whilst completing exercise. It has been concluded that in OA there is limited evidence that interventions can improve exercise adherence. Therefore, an understanding of non-adherence and the effects of kinesiophobia is essential to further develop exercise programmes for patients with OA.
A colloid preparation of platinum and palladium scavenges active oxygen and thus produces surprising effects for treatment and prevention of diseases, enhancement in vitality of the human body and improvement in health. Since, however, air and oxygen should be cut off for its stable storage, the preparation should have been in the form of an ampoule. In the present invention, the internal surface of a capsule is coated with chitosan for protecting the colloid solution of platinum and palladium against air and oxygen, that is, cutting off air and oxygen. Specifically, an about 2% acidic solution of chitosan having a molecular weight of 500 to 5000 and dissolved under such an acidic condition that the pH is not more than 4 is sprayed on the internal surface of a gelatin film for the preparation of a soft capsule, followed by drying to a small extent. For realizing the acidic condition, the use of an organic acid acceptable as a food additive is preferred. In the preparation of a soft capsule, the use of a coating with the internal surface thereof being coated with chitosan can provide a soft capsule which enables an aqueous solution, such as a colloidal solution of platinum and palladium, to be encapsulated therein and can realize protection against air.
INLYTA in combination with avelumab can cause severe and fatal cardiovascular events. Consider baseline and periodic evaluations of left ventricular ejection fraction. Monitor for signs and symptoms of cardiovascular events. Optimize management of cardiovascular risk factors, such as hypertension, diabetes, or dyslipidemia. Permanently discontinue INLYTA and avelumab for Grade 3–4 cardiovascular events.

MACE occurred in 7% of patients with advanced RCC treated with INLYTA in combination with avelumab compared to 3.4% treated with sunitinib in a randomized trial, JAVELIN Renal 101. These events included death due to cardiac events (1.4%), Grade 3–4 myocardial infarction (2.8%), and Grade 3–4 congestive heart failure (1.8%). Median time to onset of MACE was 4.2 months (range: 2 days to 24.5 months).
There is limited evidence linking exposure to heavy metals, especially mixed metals, to stress urinary incontinence (SUI). This study aimed to explore the relationship between multiple metals exposure and SUI in women. The data were derived from the National Health and Nutrition Examination Survey (NHANES), 2007-2020. In the study, a total of 13 metals were analyzed in blood and urine. In addition, 5155 adult women were included, of whom 2123 (41.2%) suffered from SUI. The logistic regression model and restricted cubic spline (RCS) were conducted to assess the association of single metal exposure with SUI risk. The Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) were used to estimate the combined effect of multiple metals exposure on SUI. First, we observed that blood Pb, Hg and urinary Pb, Cd were positively related to SUI risk, whereas urinary W was inversely related by multivariate logistic regression (all p-FDR < 0.05). Additionally, a significant non-linear relationship between blood Hg and SUI risk was observed by RCS analysis. In the co-exposure models, WQS model showed that exposure to metal mixtures in blood [OR (95%CI) = 1.18 (1.06, 1.31)] and urine [OR (95%CI) = 1.18 (1.03, 1.34)] was positively associated with SUI risk, which was consistent with the results of BKMR model. A potential interaction was identified between Hg and Cd in urine. Hg and Cd were the main contributors to the combined effects. In summary, our study indicates that exposure to heavy metal mixtures may increase SUI risk in women.
PURPOSE:To obtain from seaweed the title composition for fish feed for preventing an abnormal phenomenon in ocean culture by mixing a highly unsaturated fatty acid obtained from the lipid part of a red alga 'Fudaraku' with a saturated fatty acid. CONSTITUTION:The composition comprises a liquid formed from 38-55 pts.wt. highly unsaturated fatty acid obtained from the lipid part of a red alga 'Fudaraku' and 30-50 pts.wt. fatty acid. A highly unsaturated oil or fat with advanced function, such as eicosapentaenoic acid(EPA), cannot be formed in the body of fish. Accordingly, the conventional feed for the cultivation of fish, etc., which contains no or little EPA tends to result in an abnormal growth of a fry. The composition prepared from the seaweed can prevent the abnormality when added to the feed for the cultivation of fish, etc.
The invention discloses a light-controlled hydrogel based on P(MVE-alt-MA). Grafting polymer host and guest are obtained by modifying P(MVE-alt-MA) with beta-cyclodextrin and p-aminoazobenzene respectively; and the hydrogel is formed by assembling the polymer host and guest. The invention also discloses a preparation method of the light-controlled hydrogel based on P(MVE-alt-MA). Raw materials are cheap; and the preparation method has a simple synthetic route and a short cycle, has no pollution, and is suitable for large-scale production. A single component P(MVE-alt-MA) is adopted, so that a crosslinking degree of the hydrogel can be regulated by adjusting a host-guest proportion easily, and industrialization is facilitated. Under irradiation of ultraviolet light, the hydrogel is changed into a sol. The hydrogel has good response to light; and a response process is reversible. The hydrogel can be used for drug controlled release and cell 3D culture vectors.
"Brittle nails," referring to nails that chip, peel, or split excessively, occur in up to 30% of women and 15% of men, with highest prevalence among the elderly. Treatment of brittle nails involves restoration and maintenance of a normal degree of nail plate hydration by minimizing exposure to dehydrating chemicals and by use of moisturizers, such as alpha-hydroxy acids. Retinoids are vitamin A analogs that play a role in skin cell differentiation and proliferation. Tazarotene is a topical receptor-selective synthetic retinoid that normalizes epidermal differentiation and reduces the influx of inflammatory cells into the skin. In this single-center, open-label trial, subjects applied tazarotene to the nails twice daily for 24 weeks. Signs and symptoms were rated by the investigators and subjects during treatment and 12 weeks after discontinuation.
The invention discloses a montelukast orally disintegrating tablet. The montelukast orally disintegrating tablet is prepared from montelukast microspheres and pharmaceutically acceptable excipients and is prepared by a powder direct pressing method or a dry method for granulating and tabletting. Particularly, the montelukast microspheres are formed by combining montelukast with high polymer materials, an opacifying agent and an antisticking agent. The pharmaceutically acceptable excipients comprise a filling agent, a binding agent, a disintegrating agent, a lubricating agent and a corrigent. The montelukast orally disintegrating tablet disclosed by the invention is stable in property, is proper in mouthfeel and can be taken under the condition of no water; the property that the montelukast is optically unstable is greatly improved, and the compliance of an allergic sufferer is remarkably improved. The montelukast orally disintegrating tablet disclosed by the invention is simple in preparation process and low in production cost; the industrial demand can be met.
Participants will receive RO7445482 (Dose 1) in addition to their background NUC therapy for the 48-week treatment period. At the end of the treatment period, participants will continue NUC treatment during the follow-up unless the NUC discontinuation criteria have been met.
PROBLEM TO BE SOLVED: To obtain a safe hyaluronic acid synthesis promoter comprising ingredients derived from whey and obtained by treating whey of mammal with an acid and an alcohol and removing insoluble matter and capable of recovering skin structure in early age and preventing aging of skin. SOLUTION: This hyaluronic acid synthesis promoter comprises ingredients derived from whey and obtained by treating whey of mammal with an acid (e.g. hydrochloric acid or acetic acid) and an alcohol (e.g. ethanol) under conditions of pH 1-5 and 10-50 (v/v)% alcohol concentration and removing insoluble matter. A whey obtained by defatting milk and filtering the defatted milk with celite is preferable as the serum of mammal. One or two or kinds of serums selected from serums of human, cow, goat, sheep and pig and preferable as the serum. The ingredient derived from serum are formulated, preferably in an amount of 0.00001-10.0 wt.% expressed in terms of solid content in the case of a lotion. Skin lotion such as lotion preparation, milk lotion, cream or ointment is preferable as a formulation of the promoter.
BACKGROUND: Although moderate endurance exercise has been reported to improve cardiovascular health, its effects on cardiac structure and function are not fully characterized, especially with respect to sexual dimorphism. We aimed to assess the effects of moderate endurance exercise on cardiac physiology in male versus female mice.
METHODS AND RESULTS: C57BL/6J mice of both sexes were run on a treadmill for 6 weeks. ECG and echocardiography were performed every 2 weeks. After 6 weeks of exercise, mice were euthanized, and triple parametric optical mapping was performed on Langendorff perfused hearts to assess cardiac electrophysiology. Arrhythmia inducibility was tested by programmed electrical stimulation. Left ventricular tissue was fixed, and RNA sequencing was performed to determine exercise-induced transcriptional changes. Exercise-induced left ventricular dilatation was observed in female mice alone, as evidenced by increased left ventricular diameter and reduced left ventricular wall thickness. Increased cardiac output was also observed in female exercised mice but not males. Optical mapping revealed further sexual dimorphism in exercise-induced modulation of cardiac electrophysiology. In female mice, exercise prolonged action potential duration and reduced voltage-calcium influx delay. In male mice, exercise reduced the calcium decay constant, suggesting faster calcium reuptake. Exercise increased arrhythmia inducibility in both male and female mice; however, arrhythmia duration was increased only in females. Lastly, exercise-induced transcriptional changes were sex dependent: females and males exhibited the most significant changes in contractile versus metabolism-related genes, respectively.
CONCLUSIONS: Our data suggest that moderate endurance exercise can significantly alter multiple aspects of cardiac physiology in a sex-dependent manner. Although some of these effects are beneficial, like improved cardiac mechanical function, others are potentially proarrhythmic.
Investigating the gut microbiome and metabolome frequently requires faecal samples, which can be difficult to obtain. Previous studies have shown that rectal swabs are comparable to faecal samples for analysing gut microbiota composition and key metabolites. In this study, 3D printed rectal swabs were compared with conventional flocked swabs and faecal samples, due to the potential advantages 3D printing as a technique offers for swab production and development. 16S rRNA gene sequencing, qPCR and metabolite profiling (using 1H-NMR spectroscopy) were performed on swab and faecal samples from healthy participants. Faecal calprotectin and total protein analysis were performed on samples from inflammatory bowel disease (IBD) patients. There were no significant differences between both swab types and faecal samples when assessing key measures of alpha and beta diversity, and differences in the abundance of major phyla. There was a strong correlation between both swab types and faecal samples for all combined metabolites detected by NMR. In IBD patients, there was no significant difference in faecal calprotectin and total protein levels between both swab types and faecal samples. These data lead us to conclude that 3D printed swabs are equivalent to flocked swabs for the analysis of the gut microbiome, metabolome and inflammation.
This invention involves a method for reducing neurotoxic side effects that can be caused when NMDA antagonists such as MK-801 are used as anti-convulsants, to prevent excitotoxic damage in the central nervous system, or for anesthetic purposes in human or veterinary medicine. This method involves the use of anti-cholinergic agents such as scopolamine, atropine, benztropine, trihexyphenidyl, biperiden, procyclidine, benactyzine, or diphenhydramine in conjunction with, or subsequent to, administration of an NMDA antagonist. These anti-cholinergic agents greatly reduce or eliminate the deleterious side effects that can accompany NMDA antagonists (such as convulsion potentiating effects, as well as vacuole formation, mitochondrial dissolution, and possible death of cingulate/retrosplenial cerebrocortical neurons), without interfering with the useful properties of the NMDA antagonists. The protective agents described herein may also reduce the neurotoxic, psychotoxic, and/or hallucinatory side effects associated with illegal use of drugs such as phencyclidine. This invention also relates to mixtures of NMDA antagonists and anti-cholinergic agents. Such mixtures can be used for beneficial purposes, such as providing safe anesthesia or ameliorating neurological disease processes, while also preventing deleterious side effects that might otherwise be caused by the NMDA antagonists.
NEW MATERIAL:The ascochlorin derivative of formula (AS-6-C). USE:A remedy for II-type diabetes (insulin-independent diabetes). It acts to the peripheral tissue, restores its insulin-sensitivity and reactivity, and shifts the diabetic metabolism toward normal metabolism. The compound exhibits comparable remedying effect to AS-6 (4-O-carboxymethylascochlorin) which is a starting material of the compound, and furthermore, the compound has remarkably improved safety because it is secreted rapidly from the body. PREPARATION:The compound of formula can be prepared nearly quantitatively, either by (i) vigorously agitating a dilute alkaline solution of AS-6 in the presence of ground animal liver for a definite period, or by (ii) oxidizing the above AS-6 solution with a group of bacteria known as oxidizing bacteria (e.g. bacteria belonging to Pseudomonas genus).
PURPOSE: This study compared COVID-19 vaccination intentions in those with and without chronic diseases (CDs and non-CDs) in South Korea. We hypothesized that the factors associated with COVID-19 vaccination intentions would differ between CDs and non-CDs in South Korea.
METHODS: Using survey data collected through a Korean online panel in June 2021, we conducted a cross-sectional secondary data analysis. Of the 2292 participants, 411 had at least one chronic disease. To construct a comparable dataset, we selected non-CDs via a 1:1 case-control matching for age and gender. We then utilized a multivariable binary logistic regression model to explore the factors contributing to COVID-19 vaccination intentions in CDs and non-CDs.
RESULTS: All told, over 75% of participants in both groups indicated that they intended to vaccinate against COVID-19. In both groups, those who mistrusted general vaccine benefits reported significantly lower COVID-19 vaccination intentions. Regarding factors associated with vaccination intentions, CDs identified anxiety regarding coronavirus and exposure to COVID-19 vaccination promotions at the community level, while non-CDs highlighted hesitancy regarding vaccines and confidence in government/health services.
CONCLUSION: Improving vaccination acceptance will require the development and implementation of tailored approaches for CDs and non-CDs and efforts to minimize general vaccine mistrust.
Morphine Sulfate Injection is intended for intravenous and intramuscular administration.

Morphine Sulfate Injection is available in five concentrations for direct injection. Dosing errors can result in accidental overdose and death. Avoid dosing errors that may result from confusion between mg and mL and confusion with morphine injections of different concentrations when prescribing, dispensing, and administering Morphine Sulfate Injection. Ensure that the dose is communicated and dispensed accurately.

Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5.1)]. 

Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse [see Warnings and Precautions (5.1)] . 

Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of initiating therapy and following dosage increases with Morphine Sulfate Injection and adjust the dosage accordingly [see Warnings and Precautions (5.2)]. 

Administration of Morphine Sulfate Injection should be limited to use by those familiar with the management of respiratory depression. Morphine must be injected slowly; rapid intravenous administration may result in chest wall rigidity.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if color is darker than pale yellow, if it is discolored in any other way or if it contains a precipitate.
Patients under medication for addiction treatment (MAT) that are active members of the Greek Organization Against Drugs (OKANA) therapeutic units will be recruited for this investigation. The participants will be stratified into two subgroups, i.e., methadone maintenance treatment (MMT) and buprenorphine maintenance treatment (BMT), according to the maintenance treatment program they attend. Pomegranate juice, which is the examined nutritional intervention, will be administered to the participants of both MMT and BMT subgroups of the experimental group. The juice will be administered to the patients at the following dosage: 250 ml/day, seven days/week, for four months.
Participants who completed the DEP were randomized 1:1 to receive placebo orally immediately after meals. Participants remained on the same dose of placebo for the duration of the RWP; doses of placebo were not permitted to be modified during the RWP.
Lumbar disc hernia (LDH); It is one of the common spinal problems that occur in the form of low back pain and radiculopathy that spreads to the lower extremities. The prevalence of lumbar disc herniation reported in individuals with low back pain; It ranges from 0% to 47%. It has been reported that the highest prevalence of LDH is in adults between the ages of 30-50. Disc herniation at the L4-5 and L5 - S1 spinal levels is more common in adults over the age of 55. The most important complaint in LDH is pain, and patients often complain of a blunt pain in the lumbar region. Weakness in the muscles surrounding the vertebra can cause balance and walking problems. For Lumbar Disc Hernia, sedentary life, gender, high body mass index, occupation, smoking, psychosocial factors and people exposed to vibration for a long time are among the risk factors. Lack of time is reported to be the biggest obstacle to exercising. In addition, kinesiophobia, that is the fear of pain due to movement, is very common in this group. Physical activity and exercise are arguably the most comprehensive therapeutic agent for a long-term and fundamentally established society. There is a consensus on the review of the current literature that it positively affects the risk of exercise disease, but not all, risk factors, diseases, and disability between middle and advanced age. Whole Body Electromyostimulation (WB-EMS), a technology that addresses nine (main) muscle groups, may be a good option. Given the low training intensity of 1-2 sessions per week for 20 sessions, it may be of interest to people who are close to traditional exercise programs, with low volunteer intensity and a high degree of oversight and individualization of existing WB-EMS settings.
Transitioning to adulthood is a complex and challenging process for youth with complex communication needs (CCN) and/or who use augmentative and alternative communication (AAC). This scoping review examined and consolidated available evidence documenting transition barriers and facilitators. Eight databases were searched systematically using complex communications needs/augmentative and alternative communication, transition programs, and adulthood as key terms. Participants aged 14-35 years and interventions focused on transition to occupations, including education, employment, leisure pursuits, or socializing/relationships. The search yielded 3459 records, which were screened by three independent raters. Twenty-three articles met the inclusion criteria. Studies focused primarily on employment (n =18), postsecondary education (n = 10), and socializing/relationships (n = 13). Programs experience and outcomes varied. Enabling factors included organizations, transition-focused programs, and social networks. Barriers included low expectations, lack of programs/supports, and limited literacy skills. Future studies must include richer descriptions of programs/services and participants, while more work is required to explore long-term outcomes.