anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pre-eclampsia is a potentially serious condition that affects pregnant women. It is usually diagnosed during routine antenatal appointments. This is based on blood pressure measurements and results of urine protein tests that are recommended at each routine antenatal visit to screen for the condition. The Triage PlGF test and the Elecsys immunoassay sFlt-1/PlGF ratio is also recommended to help rule out the condition in women presenting with suspected pre-eclampsia between 20 weeks and 34 weeks of pregnancy plus 6 days. If diagnosed with pre-eclampsia, women are usually referred to a specialist in hospital for further tests and more frequent monitoring. Depending on the severity of the condition, some women may be monitored as outpatients while others may need admission to hospital for closer monitoring or to have the condition managed in a critical care setting.

The Lumella test is based on the novel biomarker GlyFn. The company states that compared with other currently used biomarkers (such as soluble fms-like tyrosine kinase-1 \[sfIT-1\] and placental growth factor \[PlGF\] or PlGF alone), GlyFn is etiological to pre-eclampsia and maintains a linear progression throughout pregnancy. The company also claims that the test offers improved sensitivity and specificity over standard care tests. This would lead to a reduction in false positives and false negatives. The Lumella test requires a finger prick blood sample (5 microlitres). Other pre-eclampsia tests currently used in the NHS need a phlebotomy blood sample, which can be difficult to collect in some people. The test can also be transported and stored at room temperature. Other tests for pre-eclampsia need to be refrigerated and brought to room temperature before the test can be done. The Lumella test may improve patient experience and allow a more rapid turnaround time for results. The company states that Lumella is currently the only test that can be done within 10 minutes at room temperature.
PROBLEM TO BE SOLVED: To obtain an antibiotic exhibiting an excellent antitumor action against solid tumor and multiple medicine-resistant tumor and capable of being used for cancer chemotherapy by compounding a specific compound (salt) as an active ingredient. SOLUTION: This antitumor agent contains a compound (salt) of the formula [R is CH3, CH(CH3)2 or CH(CH3)CH2CH3] as an active ingredient. The compound can be obtained by culturing Streptomyces sp. SNA 15896 strain to produce the compound in the culture product, and subsequently collecting the compound. The strain is deposited as FERM P-16667. The compound is obtained, for example, by a fermentation method using Streptomyces braegensis N617-29 strain.
Water deficit stress limits net photosynthetic rate (AN), but the relative sensitivities of underlying processes such as thylakoid reactions, ATP production, carbon fixation reactions, and carbon loss processes to water deficit stress in field-grown upland cotton require further exploration. Therefore, the objective of the present study was to assess (1) the diffusional and biochemical mechanisms associated with water deficit-induced declines in AN and (2) associations between water deficit-induced variation in oxidative stress and energy dissipation for field-grown cotton. Water deficit stress was imposed for three weeks during the peak bloom stage of cotton development, causing significant reductions in leaf water potential and AN. Among diffusional limitations, mesophyll conductance was the major contributor to the AN decline. Several biochemical processes were adversely impacted by water deficit. Among these, electron transport rate and RuBP regeneration were most sensitive to AN-limiting water deficit. Carbon loss processes (photorespiration and dark respiration) were less sensitive than carbon assimilation, contributing to the water deficit-induced declines in AN. Increased energy dissipation via non-photochemical quenching or maintenance of electron flux to photorespiration prevented oxidative stress. Declines in AN were not associated with water deficit-induced variation in ATP production. It was concluded that diffusional limitations followed by biochemical limitations (ETR and RuBP regeneration) contributed to declines in AN, carbon loss processes partially contributed to the decline in AN, and increased energy dissipation prevented oxidative stress under water deficit in field-grown cotton.
PROBLEM TO BE SOLVED: To stabilize vitamin B1or the like in a preparation and to improve disintegrability of a solid preparation containing a glycosaminoglycan such as chondroitin sulfate.SOLUTION: Vitamin B1 or the like are stabilized by incorporating amino sugars (such as glucosamine) into a preparation containing vitamin B1 or the like. The amount of the amino sugars to be used is an effective amount for stabilizing vitamin B1 or the like, for example, at least 0.1 pt.wt. based on 1 pt.wt. of vitamin B1 or the like. Incorporation of the amino sugars improves disintegrability of a solid preparation including glycosaminoglycans (hyaluronic acid, chondroitin or salts thereof). The amount of amino sugars to be used is at least 0.1 pt.wt. based on 1 pt.wt. of glycosaminoglycans. The solid preparation, even when a pH fluctuates, suppresses formation of a mass of gel of a glycosaminoglycan to improve disintegrability.
PROBLEM TO BE SOLVED: To provide a cosmetic having a transparent feeling in spite of having a sufficient covering force, exhibiting a natural finish, not showing pores of a skin, spots and freckles as conspicuous and excellent in both adhesion and ductility/malleability. SOLUTION: This cosmetic contains (A) a compounded inorganic powdery material showing 7-15 difference between each of the amounts of surface reflected light measured under conditions of 45 deg. incident light angle and 45 deg. receiving light angle, and 45 deg. incident light angle and 0 deg. receiving light angle in measuring the amount of a surface-reflected light angle and the amounts of a powder layer-reflected light angle under light receiving conditions of 2 views with C light by using a variable angle photometer mounted with an S polarized plate or a P polarized plate in its incident light side and receiving light side respectively on a specimen obtained by uniformly applying 10 mg mixture (weight ratio=47:47: 6) of the compounded inorganic powdery material, talc and squalane on a part of 10 cm× 5 cm of a black colored artificial leather, and also (-)3-3 difference between the amount of the surface- reflected light and the amount of the powder layer-reflected light measured at 45 deg. incident light angle and 0 deg. receiving light angle, and (B) 1 kind or >=2 kinds of spherical compounded powder selected from a resin dispersed with titanium oxide or zinc oxide at its inside and loaded with zirconium oxide or aluminum oxide on its surface and silicon oxide.
FIELD: biotechnology.SUBSTANCE: invention relates to the biotechnology. Disclosed is a binding element specific for binding to TNF-alpha, including: (i) heavy chain CDR-H1, CDR-H2 and CDR-H3 variable sequences presented in SEQ ID No: 6, 7 and 8; and (ii) light chain CDR-L1, CDR-L2 and CDR-L3 variable sequences presented in SEQ ID No: 3, 4 and 5. Also disclosed is an isolated nucleic acid molecule comprising a sequence which codes the binding element. Disclosed is a method of producing said binding member. Besides, the corresponding expression vector and the host cell and compositions are presented. Invention can be used in treating inflammatory and other diseases, as well as in diagnostics.EFFECT: disclosed is a method of treating TNFα-mediated disease and a method of detecting the presence of TNF-alpha in a biological sample.36 cl, 4 dwg, 4 tbl, 9 ex
Staff performing echocardiography exams work in a physically demanding environment. The physical and psychosocial demands of the work environment place a significant amount of stress on the physical well being of the employee. The nature of the work involved includes repetitive movements and static holds while applying intense pressure. These compounded by a challenging ergonomic work environment, often leads to physical tension, pain, and fatigue. Staff and patient characteristics, in particular obesity, present greater ergonomic challenges. In this setting, optimal ergonomics can be difficult to achieve. Repetitive actions in an ergonomically challenging environment can have an accumulative effect that can lead to injury.

Massage therapy has been noted to decrease levels of anxiety and fatigue which is essential to maintaining efficient care in a dynamic environment. Repetitive use, typically leads to shortened, tight muscles that fatigue over time. Once the massage therapy has released the connective tissue tension and restored muscle imbalances, exercise focused on core, trunk strength and those muscles which oppose the repetitively used muscles can further assist the therapeutic benefits of massage.

The cardiac sonographer is usually sitting and reaching forward or to the side, and the musculoskeletal imbalances show up primarily superior to the hips. Massage Therapy research for alleviating musculoskeletal symptoms has been with the use of table massage whereas chair massage research has focused on gaining physiological benefits. Chair massage therapy impacts the head, back, neck shoulders, arms and hands so does impact the areas of musculoskeletal imbalance of the cardiac sonographer. In addition, a massage chair is easy to set up, does not need a great deal of space, and can be provided in semi-private area, as the participant remains clothed. Chair massage literature to date has focused more on physiological responses and albeit positive, not as much on musculoskeletal responses.
<P>PROBLEM TO BE SOLVED: To provide a method for producing an emulsion type acrylic adhesive, capable of producing a polymer emulsion (acrylic emulsion) in a good polymerization stability without using nonylphenol as an emulsifier.  <P>SOLUTION: This method for producing the emulsion type acrylic adhesive is provided by emulsion polymerizing monomers consisting mainly of a (meth)acrylic acid alkyl ester in the presence of an emulsifier containing at least a sulfosuccinic acid salt. Suitably, the emulsifier containing at least the sulfosuccinic acid salt contains 0-50 pt./pts.wt. another emulsifier than the sulfosuccinic acid salt based on 100 pts.wt. sulfosuccinic acid salt, and the using amount of the emulsifier containing at least the sulfosuccinic acid salt is 0.5-5 pt./pts.wt. based on 100 pts.wt. monomers.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The invention discloses throat-clearing and sore-throat-relieving candies. The throat-clearing and sore-throat-relieving candies are prepared from the following ingredients: isomaltitol, boat-fruited sterculia seeds, semen oroxyli, liquorice roots, radix platycodonis, radish seeds, Chinese olive fruits, Chinese atractylodes, and water. The throat-clearing and sore-throat-relieving candies disclosed by the invention contain the following ingredients: the extracts of boat-fruited sterculia seeds, semen oroxyli, liquorice roots, radix platycodonis, radish seeds, Chinese olive fruits and Chinese atractylodes; thus, the throat-clearing and sore-throat-relieving candies have the functions of clearing away heat, detoxifying, clear the throat, relieving sore throat, benefiting the stomach, increasing body fluid, eliminating phlegm, removing stasis, soothing, calming the nerves and so on. With respect to the conditions of hoarse voice, uncomfortable throat and the like, the throat-clearing and sore-throat-relieving candies have the characteristics of quick and good effects, and are free of toxic and side effects. The isomaltitol is utilized as the sweetener of the throat-clearing and sore-throat-relieving candies, and has purer and more natural sweet taste compared with other sweeteners; and the utilization of the isomaltitol also makes the applicable crowd to become wider. The isomaltitol is non-carious, so that the streptococcus mutans in the oral cavity cannot be decomposed and utilized; therefore, no acid and glucan are produced, and no decayed teeth are caused; therefore, the throat-clearing and sore-throat-relieving candies can be eaten by children. Moreover, the throat-clearing and sore-throat-relieving candies do not cause elevation of glycemia and insulin, so that the candies can also be eaten by the patients with diabetes.
In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.
<P>PROBLEM TO BE SOLVED: To provide a skin beautifying agent having excellent all-around skin-beautifying effects such as high safety, prevention of skin drabness, chapped skin and stains and improvement in wrinkles, and to provide a skin care preparation having a skin-beautifying effect, a cosmetic, a bath medicine and a detergent.  <P>SOLUTION: The agent includes a carotenoid and a sphingolipid. The carotenoid is preferably a cryptoxanthin. The carotenoid and/or the sphingolipid is preferably derived from one or more plants selected from the group consisting of a plant of citrus fruit, a persimmon, Eriobotrya japonica, mango, papaya, red bell pepper and Guinea pepper. The plant of citrus fruit is preferably Citrus unshiu Markovich.  <P>COPYRIGHT: (C)2009,JPO&INPIT
1,181,605. The antibiotic libanomycin. SOC. FARMACEUTICI ITALIA. 23 April, 1968 [28 April, 1967], No. 19064/68. Heading C2A. An antibacterial, antifungal, antibiotic libanomycin, which also has growth factor properties in the human and veterinary field, is produced by the aerobic cultivation of a libanomycinproducing strain of Streptomyces libani n.sp. in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and mineral salts at pH 5 to 8À8. The strains specified are F.I. 2343 (I.M.I. 130777 and I.M.R.V. 3915), F.I. 2399 (I.M.I. 130778 and I.M.R.V. 3916), F.I. 2501 (I.M.I. 130779 and I.M.R.V. 3917) and F.I. 2521 (I.M.I. 131233 and I.M.R.V. 3918). Libanomycin is a complex of components A, B and C. Crude libanomycin is isolated from the mycelium and also from the clarified broth. The mycelium is extracted with aqueous alcohol or. aqueous acetone and the extract is concentrated to precipitate the crude complex. The clarified broth is extracted with butyl alcohol at pH 7À5 to 8À5, the butanol extract concentrated and the crude antibiotic precipitated by the addition of acetone or diethyl ether. Alternatively, the antibiotic may be adsorbed on a carboxylic cationic exchange resin in the acid form. The resin is washed with water and then with 0À5 N NH 4 OH and the antibiotic is eluted with alcoholic aqueous saline, e.g. NaCl in aqueous CH 3 OH and the eluate concentrated and extracted with butanol. The crude is dissolved in alcohol and the solution is chromatographed on a column of neutral activated alumina or silica gel. Alcoholic elution fractions containing B, A and B and A and C are obtained. These fractions are further purified by chromatography on cellulose powder followed by elution with butanol: pyridine: water (6:3:4). Soluble in aqueous alcohols, aqueous acetone, methanol, ethanol, pyridine, dimethylformamide and dimethylsulphoxide; sparingly soluble in water; insoluble in acetone, chloroform, benzene, diethyl ether and petroleum ether. A pharmaceutical composition for oral or parenteral use comprises one or more of the antibiotics libanomycin complex and its components A, B and C and a carrier. The antibiotic (including mycelium) may be incorporated in animal feeds as a nutritional supplement.
In this 4-week sleep protocol, children in this experimental condition follow a Stabilized Sleep schedule (i.e., their usual bed time) during weeks 1, 3 and 4. During week 2, they follow a Shortened Sleep schedule, during which they go to bed 90 later than is typical.
INTRODUCTION: Gestational diabetes mellitus (GDM) is a major pregnancy metabolic disorder and is strongly linked with obesity. Kisspeptin is a hormone that increases several thousand-fold in the maternal circulation during human pregnancy, with placenta as its main source. Studies have suggested that kisspeptin regulates trophoblast invasion and promotes pancreatic insulin secretion and peripheral insulin sensitivity.
METHODS: In a well-characterized cohort of pregnant South African women and molecular and histological techniques, this study explored the impact and interaction of maternal obesity and GDM on kisspeptin (KISS1) signalling in relation to placental morphology and maternal and neonatal parameters.
RESULTS: We found that GDM had no effect on placental KISS1 and KISS1R (KISS1 receptor) mRNA and/or protein expression. However, obesity reduced placental KISS1R mRNA expression even though overall KISS1 protein abundance or localization was not different from the non-obese group. Maternal and cord circulating KISS1 concentrations did not vary with obesity or GDM, but maternal circulating KISS1 was positively correlated with placenta weight in non-GDM obese women, and negatively correlated with placental intervillous space volume in non-GDM non-obese women. Cord serum KISS1 was positively correlated with infant weight in GDM obese women, but negatively correlated with maternal BMI in the non-obese GDM group. Placental syncytiotrophoblast extracellular vesicles exhibited detectable KISS1 and its abundance was ∼50 % lower in those from obese GDM compared to non-GDM women.
DISCUSSION: This study shows maternal obesity and GDM can modulate placental kisspeptin signalling and placental morphological development with potential pathophysiological implications for clinically-relevant pregnancy and perinatal outcomes.
In pulmonary hypertension (PHTN), a metabolic shift to aerobic glycolysis promotes a hyperproliferative, apoptosis-resistant phenotype in pulmonary arterial smooth muscle cells (PASMCs). Enhanced glycolysis induces extracellular acidosis, which can activate proton-sensing membrane receptors and ion channels. We previously reported that activation of the proton-gated cation channel acid-sensing ion channel 1a (ASIC1a) contributes to the development of hypoxic PHTN. Therefore, we hypothesize that enhanced glycolysis and subsequent acidification of the PASMC extracellular microenvironment activate ASIC1a in hypoxic PHTN. We observed decreased oxygen consumption rate and increased extracellular acidification rate in PASMCs from chronic hypoxia (CH)-induced PHTN rats, indicating a shift to aerobic glycolysis. In addition, we found that intracellular alkalization and extracellular acidification occur in PASMCs following CH and in vitro hypoxia, which were prevented by the inhibition of glycolysis with 2-deoxy-d-glucose (2-DG). Inhibiting H+ transport/secretion through carbonic anhydrases, Na+/H+ exchanger 1, or vacuolar-type H+-ATPase did not prevent this pH shift following hypoxia. Although the putative monocarboxylate transporter 1 (MCT1) and -4 (MCT4) inhibitor syrosingopine prevented the pH shift, the specific MCT1 inhibitor AZD3965 and/or the MCT4 inhibitor VB124 were without effect, suggesting that syrosingopine targets the glycolytic pathway independent of H+ export. Furthermore, 2-DG and syrosingopine prevented enhanced ASIC1a-mediated store-operated Ca2+ entry in PASMCs from CH rats. These data suggest that multiple H+ transport mechanisms contribute to extracellular acidosis and that inhibiting glycolysis-rather than specific H+ transporters-more effectively prevents extracellular acidification and ASIC1a activation. Together, these data reveal a novel pathological relationship between glycolysis and ASIC1a activation in hypoxic PHTN.NEW & NOTEWORTHY In pulmonary hypertension, a metabolic shift to aerobic glycolysis drives a hyperproliferative, apoptosis-resistant phenotype in pulmonary arterial smooth muscle cells. We demonstrate that this enhanced glycolysis induces extracellular acidosis and activates the proton-gated ion channel, acid-sensing ion channel 1a (ASIC1a). Although multiple H+ transport/secretion mechanisms are upregulated in PHTN and likely contribute to extracellular acidosis, inhibiting glycolysis with 2-deoxy-d-glucose or syrosingopine effectively prevents extracellular acidification and ASIC1a activation, revealing a promising therapeutic avenue.
Oncology patients candidate for rectal surgery (tumors located up to 15 cm from the anal margin) and meet inclusion criteria. Rectoscope (P201630551) allows the identification of the distal section margin.
Even though the capability of aircraft manufacturing has improved, human factors still play a pivotal role in flight accidents. For example, fatigue-related accidents are a common factor in human-led accidents. Hence, pilots' precise fatigue detections could help increase the flight safety of airplanes. The article suggests a model to recognize fatigue by implementing the convolutional neural network (CNN) by implementing flight trainees' face attributions. First, the flight trainees' face attributions are derived by a method called the land-air call process when the flight simulation is run. Then, sixty-eight points of face attributions are detected by employing the Dlib package. Fatigue attribution points were derived based on the face attribution points to construct a model called EMF to detect face fatigue. Finally, the proposed PSO-CNN algorithm is implemented to learn and train the dataset, and the network algorithm achieves a recognition ratio of 93.9% on the test set, which can efficiently pinpoint the flight trainees' fatigue level. Also, the reliability of the proposed algorithm is validated by comparing two machine learning models.
Pharmaceutical compositions comprising a sulfated polysaccharide and a shear-thinning fluid gel are provided. For example, the sulfated polysaccharide may be selected from the group consisting of: dextran sulfate having an average molecular weight of 10,000da or less; heparan sulfate; fucoidan; degraded carrageenan; furcellaran; and carrageenan. The shear-thinning fluid gel may comprise a microgel particle forming polymer suitably selected from one or more of the following groups: gellan gum; an alginate; carrageenan (E); agarose; chitosan; pectin; agarose; agar or gelatin. The disclosed compositions are useful for preventing and/or treating glaucoma. These compositions are useful for inhibiting or reducing fibrosis. The invention also relates to the medical use of sulfated polysaccharides, and to the medical use of shear-thinning fluid gels.
The patients are recurrent, refractory or progressive high-grade glioma including Diffuse Intrinsic Pontine Glioma patients. Patients may take crenolanib as an intact tablet or crushed in apple sauce/juice. Currently accruing to dose level 4 (220 mg/m\^2).