anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Disclosed are a peripheral blood TCR marker for colorectal cancer, a detection kit therefor and an application thereof. The marker comprises at least one of the proteins set forth in the sequence SpecSeq1-100. In the present invention, on the basis of a high-throughput sequencing method, only a small amount of peripheral blood needs to be taken. RNA is extracted, and an immune profile library is established by means of processing samples. Next, a characteristic TCR sequence in the peripheral blood of colorectal cancer is first determined by means of high-throughput sequencing and TCR data analysis, and then test results of a sample to be tested are compared to the characteristic TCR sequence so as to determine whether a patient has colorectal cancer. In the present invention, a huge number of colorectal cancer-specific TCR sequences may be compared at the same time, which has higher specificity and accuracy than detecting one or several markers separately, thereby increasing the diagnosis efficiency.
Following the assessment made in the participants' first menstrual cycle, on the most painful day of their second cycle (1st or 2nd day of the cycle), high-frequency TENS was applied at a frequency of 120 Hertz, at intervals of 100 µsn for 20 minutes. The intensity of the current was increased until the participant felt it.
The overall objective of this study is to evaluate the impact of the "Doing What Matters in Times of Stress Guided Self-Help Manual" on mental distress and if successful, see its impact on business performance among women entrepreneurs in Ethiopia. The study will be conducted in Addis Ababa, Ethiopia. A pilot randomized controlled trial (RCT) will be conducted to investigate the impact of the "Doing What Matters in Times of Stress Guided Self-Help Manual" intervention to reduce psychological distress and functional impairment among women entrepreneurs in Ethiopia. The investigators will screen approximately1200 women over the phone and identify 200 eligible women for the study. An in-person baseline survey will be conducted with the 200 eligible women and the participants will be randomized (using computer generated randomization) to either the doing what matters in times of stress self-help manual intervention (n=100) or wait list control (n=100). This will be followed by 6 phone-based sessions over 6-8 weeks to review handbook materials for the intervention group only. After six weeks, phone-based follow-up survey will be conducted with participants in both the intervention and control groups. If the intervention is found to be effective in reducing distress or stress at follow-up assessment, then the baseline survey will be repeated at 6-9 months post intervention both for the intervention and control group participants. Additionally, based on findings from the pilot study a larger sample of participants will be screened and enrolled (approximately 1000 women) and randomized to the intervention or wait-list control arm to be followed up at 6-9 months post intervention. The primary outcomes for this study will be psychological distress. Participants' performance on their businesses and self-esteem will be secondary outcomes for the study. A generalized linear model with appropriate statistical specifications and accounting for baseline values and any imbalanced variables at baseline (where available) will be used to analyze the data.
###  Lamivudine

Long-term carcinogenicity studies with 3TC in mice and rats showed no evidence of carcinogenic potential at exposures up to 10 times (mice) and 58 times (rats) the human exposures at the recommended dose of 300 mg. 3TC was not mutagenic in a microbial mutagenicity assay, in an in vitro cell transformation assay, in a rat micronucleus test, in a rat bone marrow cytogenetic assay, and in assay for unscheduled DNA synthesis in rat liver. 3TC showed no evidence of in vivo genotoxic activity in the rat at oral doses of up to 2000 mg per kg, producing plasma levels of 35 to 45 times those in humans at the recommended dose for HIV‑1 infection. In a study of reproductive performance, 3TC administered to rats at doses up to 4,000 mg per kg per day, producing plasma levels 47 to 70 times those in humans, revealed no evidence of impaired fertility and no effect on the survival, growth, and development to weaning of the offspring.

###  Tenofovir Disoproxil Fumarate

Long-term oral carcinogenicity studies of TDF in mice and rats were carried out at exposures up to approximately 16 times (mice) and 5 times (rats) those observed in humans at the therapeutic dose for HIV-1 infection. At the high dose in female mice, liver adenomas were increased at exposures 16 times that in humans. In rats, the study was negative for carcinogenic findings at exposures up to 5 times that observed in humans at the therapeutic dose. 

TDF was mutagenic in the in vitro mouse lymphoma assay and negative in an in vitro bacterial mutagenicity test (Ames test). In an in vivo mouse micronucleus assay, TDF was negative when administered to male mice.

There were no effects on fertility, mating performance or early embryonic development when TDF was administered to male rats at a dose equivalent to 10 times the human dose based on body surface area comparisons for 28 days prior to mating and to female rats for 15 days prior to mating through day seven of gestation. There was, however, an alteration of the estrous cycle in female rats.
Patients receive docetaxel IV and irinotecan hydrochloride as in regimen 1 induction chemotherapy. They also receive cisplatin IV over 20-30 minutes on days 1 and 8. Treatment with irinotecan hydrochloride, docetaxel, and cisplatin repeats every 3 weeks for 2 courses in the absence of disease progression or unacceptable toxicity. Patients receive docetaxel IV, irinotecan hydrochloride IV, and undergo radiotherapy as in regimen 1 chemoradiotherapy. Patients also receive cisplatin IV over 20-30 minutes on days 1 (week 8) and 8 (week 9). Treatment with irinotecan hydrochloride, docetaxel, cisplatin, and radiotherapy repeats every 3 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
The invention discloses an extractive for official rheum. According to thin-layer chromatography detection, the Rf value of the extractive is provided with two spots within the range of 0.2-0.3. The detection condition is as follows: a stationary phase is a silica gel H thin plate layer; and developing solvent is petroleum ether-ethyl formate-formic acid at the volume ratio of (13-17):(3-7):(0.5-1.5). The invention also provides an identification method for the official rheum. The extractive for the official rheum, which is disclosed by the invention, can be used as a reference substance to identify whether a seed to be detected is the official rheum seed. The detection method disclosed by the invention has the advantages of high accuracy, convenience in operation, low cost and good market application prospect.
After recruitment, signed inform consent and allocation, researcher collected demographic data of each participant. First outcome assessment was done before session. Participants received a 15-minute session of Perfetti method on affected elbow flexor.Immediate after session, last outcome assessment was collected.
Remimazolam is administered intravenously for anesthesia induction and maintenance. The dose and infusion rate is adjusted to maintain Bispectral Index (BIS) value between 40 and 60. Analgesia is maintained with remifentanil and/or sufentanil. Muscle relaxation is maintained with rocuronium and/or cisatracurium. Sevoflurane inhalation is provided when considered necessary.
The invention provides 7- ((five-membered heterocycle) methyl) -8-carboxylic acid-benzocyclobutane ester derivatives and application thereof, belonging to the field of medicines. The derivative is a compound shown in a formula I, or a salt, a conformational isomer and an optical isomer thereof. The derivative provided by the invention has good broad-spectrum inhibition activity on clinically common Metal Beta Lactamase (MBL) and Serine Beta Lactamase (SBL), can be used as an inhibitor of MBL and/or SBL enzymes, and is used for preparing antibacterial, particularly drug-resistant bacteria resistant drugs. In addition, the derivative disclosed by the invention is combined with beta-lactam antibiotic meropenem, and has better antibacterial activity on various beta-lactam antibiotic drug-resistant bacteria. The derivatives of the invention are used inThe preparation of MBL and SBL dual broad-spectrum inhibitor and the medicine for overcoming beta-lactam antibiotic drug-resistant bacteria have great potential. The invention provides a new choice for the use of antibacterial drugs and has good application prospect.
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is an acute respiratory illness characterized by bilateral chest radiographic opacities and severe hypoxemia due to noncardiogenic pulmonary edema. However, ARDS due to sing lung injury is rare. In this article, we describe a case of a female patient who developed ARDS during surgery and 1-lung mechanical ventilation.
METHODS: A 53-year-old woman developed hypoxemia 2 days after undergoing thymoma excision. Antibiotics, diuretics, expectorants, and supportive treatment strategies (noninvasive positive-pressure breathing, high-flow nasal oxygen) were used for approximately 3 days after admission to the intensive care unit (ICU), but the patient's oxygen index continued to deteriorate. Considering the possibility of ARDS being induced by 1-lung mechanical ventilation, prone positioning, methylprednisolone, nintedanib, and acetylcysteine were administered.
RESULT: Oxygenation improves greatly after 23 days admitted to ICU. Chest computed tomography shows a real reversal of the disease. The patient was discharged from ICU 29 days after admission to the ICU and was discharged from the hospital after 36 days admitted to ICU.
CONCLUSION: In this report, we describe a rare case of ARDS involved 1 lung, in which we successfully used noninvasive positive-pressure breathing, high-flow nasal oxygen, and prone positioning to succeed improvement of clinical outcomes. The use of the prone position has benefits in nonintubated patient with ARDS even involved 1 lung.
Cardiovascular system response to the microgravity includes major changes. During spaceflight, body fluids are displaced in the cephalad direction due to changes in gravity, resulting in altered vascular dynamics and the redistribution of the blood circulation. Redistribution of fluids triggers baroreceptor reflex and autonomic response initiates. Cardiovascular response to the microgravity environment is affected by gender. Women tend to lose more plasma volume and have less peripheral vascular resistance in response to microgravity analogue situations like bed rest.

Simulated microgravity leads to increased stiffness and remodeling of the aorta, a major vessel supplying blood to the abdomen, pelvis, and lower extremities. Pelvic organs are located in the lower abdomen and have rich blood supply through these major blood vessels and anastomosis. Mathematical modeling for microgravity showed a 6% mean flow rate variation in the last part of abdominal aorta. Furthermore, mean flow rate variations and resistance changed based on the branching arteries, such as internal iliac arteries. The uterine and ovarian arteries branch from the internal iliac arteries and abdominal aorta, respectively. Blood supply to an organ and tissue perfusion are vital for the proper functioning of the organs and tissues.

As we approach crewed Moon and Mars missions and commercial spaceflights become more frequent, understanding the impact of space travel on women's health is crucial. Despite the known importance of these vascular dynamics in both clinical and research settings, we have limited information on the pelvic blood flow under microgravity. Our aim is to fill this gap by analyzing the impact of simulated microgravity on the perfusion of female reproductive organs using Doppler velocimetry. Head down tilt (HDT) position is an established model in literature for simulated microgravity on Earth.

This prospective study will be conducted at Koç University Hospital. Adult women of reproductive age (18-44 years) undergoing abdominal ultrasound will be recruited. Participants will be selected from a cohort presenting for their well-woman visit; there will be no additional visits. Ultrasound and Doppler spectrometry evaluations will be carried out with convex and linear probes of the GE Loqic S8 device. We will assess pelvic organ blood flow in the supine position after a period of acclimation as a control. After completing Doppler measurements in the supine position, the participant will be placed in the HDT position. Following a period of acclimation, Doppler measurements will be repeated on the same vessels. During both supine and simulated microgravity conditions, vital signs (i.e., blood pressure, heart rate, oxygen saturation) will be collected. Pre- and post-HDT Doppler measurements will be compared and analyzed.
The invention relates to a Chinese medicine preparation with the functions of harmonizing the stomach and dispelling alcoholic effect. The Chinese medicine preparation is prepared from the raw materials of fingered citron, agastache rugosus, citron, dried tangerine peel, hovenia acerba and pu'er tea, elimintates or reduces the hurt of alcohol to the human body through harmonizing the stomach, tonifying the spleen, clearing the liver and expelling noxious substances and belongs to the field of Chinese medicine health care. Animal experiments show that the Chinese medicine preparation can obviously reduce the concentration of alcohol in the blood of a drinking rat. Clinic tests display that the alcohol content in the blood of subjects drinking after taking the drug is obviously reduced than the alcohol content in direct drinkers; meanwhile, the observation of the body feeling of the subjects after drinking finds that the drinkers drinking the drug basically do not have vomitting phenomena after drinking, but the direct drinkers have strong uncomfortable feeling and even have vomitting phenomena. Experiments also verify that the taking of the drug after drinking still has great function of dispelling the alcoholic effect. If the Chinese medicine preparation is taken 30 minutes before drinking and 30 minutes after drinking, the alcoholic effect dispelling function is better.
Participants will participate in 3 consecutive treatment periods (Periods 1, 2, and 3). In Period 1, each participant will receive a single nasal dose of JNJ-43260295 without prior nasal allergen challenge. In Period 2, each participant will receive a single nasal dose of JNJ-43260295, preceded by a nasal allergen challenge approximately 15 hours prior to the dosing. In Period 3, each participant will receive single nasal allergen challenge without JNJ-43260295. There will be a washout period of at least 21 days between 3 consecutive treatment periods.
A burr-hole craniostomy is performed and the dura is opened sharply and 10 ml of subdural exudate is aspired with blunt aspiration needle for a CSDH sample to be stored in -70℃ to be used for later analysis. Subdural space is irrigated by repeated rinsing with body temperature saline solution with a syringe and blunt needle until surgeon considers exudate to be clear. Minimum volume of irrigation will be 200 ml per operated side. The subdural drain is inserted 3-5 cm underneath the skull and parallel to it. The total volume of irrigation as well as the duration of operation is recorded.
PROBLEM TO BE SOLVED: To obtain the subject preparation capable of preventing calcitonin from adsorbing onto the syringe and administrating to humans without impairing its concentration when filled by filling a syringe with a calcitonin injection reduced in adsorptivity onto the wall surface. SOLUTION: This preparation is obtained by filling a syringe with a calcitonin injection reduced in adsorptivity onto the wall surface. The above calcitonins include elcatonin or salmon calcitonin, porcine calcitonin or human calcitonin. The calcitonin injection comprises preferably calcitonins and an adsorption- preventing ingredient. The preparation is preferably administered by injection at a dose of about 10-160 units as calcitonins. Consequently, calcitonins are preferably formulated in an amount of 0.01-10,000 units/ml as the calcitonin injection. The syringe used as a container for filling the calcitonin solution is made of glass or resin, preferably glass.
Lumbar spinal manipulation will be performed up to 8 times within 1 month (no more than 2 times per week) by Dr. WangTso-Liang, who is a well-trained and experienced manual therapy doctor. If the symptoms subside before the end of 1 month' treatment, the manipulation is discontinued.
Rare genetic diseases affect 5-8% of the population but are often undiagnosed or misdiagnosed. Electronic health records (EHR) contain large amounts of data, which provide opportunities for analysing and mining. Data mining, in the form of cluster analysis and visualisation, was performed on a database containing deidentified health records of 1.28 million patients across 3 major hospitals in Singapore, in a bid to improve the diagnostic process for patients who are living with an undiagnosed rare disease, specifically focusing on Fabry Disease and Familial Hypercholesterolaemia (FH). On a baseline of 4 patients, we identified 2 additional patients with potential diagnosis of Fabry disease, suggesting a potential 50% increase in diagnosis. Similarly, we identified > 12,000 individuals who fulfil the clinical and laboratory criteria for FH but had not been diagnosed previously. This proof-of-concept study showed that it is possible to perform mining on EHR data albeit with some challenges and limitations.
If patient is on \> 7.5 mg prednisone-equivalent daily: administer 7.5 mg q.d. for 7 days, then 5 mg q.d. for 7 days, then 2.5 mg q.d. for 7 days, then 2.5 mg q.d. every second day, then stop. If patient on 7.5 mg q.d.: maintain for 7 days, then taper as above.
JUVÉDERM® VOLBELLA™ XC injectable gel was injected into the infraorbital and adjacent area at Randomization as determined by the investigator. Participants were eligible to receive an optional touch-up treatment 1 month later and an optional repeat treatment 12 months after last treatment, if applicable. A maximum of 2.2 milliliter (mL) per side was injected for initial and touch-up treatments combined.
Pancreatic ribonuclease A coupled to human transferrin via a disulfide bond resulted in a hybrid protein that was cytotoxic to mammalian cells in vitro. In measuring protein synthesis capacity of K562 human erythroleukemia cells the IC50 for different preparations of transferrin-RNase ranged from 8 x 10-9 to 8 x 10-8 M whereas the IC¿50? of RNase or SPDP RNase alone was 1000-10,000 times higher. In a clonogenic assay 1 x 10?-6¿ M of the transferrin RNase conjugate killed 6 logs of cells whereas 7 x 10-5 M of the SPDP modified RNase had no significant effect. The inhibition of protein synthesis by transferrin-RNase was blocked by excess transferrin or ribonuclease inhibitors in the medium demonstrating that cytotoxicity was dependent on both components of the conjugate. Human serum RNase may also exhibit receptor mediated toxicities providing a new approach to selective cell killing possibly with less systemic toxicity and, importantly, less immunogenicity than the currently employed antibody-toxin conjugates.
Monitoring of pre-operative status and post-operative recovery from elective orthopaedic surgery is critical to delivering safe, value-based care. Measurement after TKA has traditionally been accomplished through clinician in-office assessments, validated surveys, or both; subjectivity, cost-effectiveness, and inconsistent reporting limit these assessments. Leveraging now ubiquitous smartphone technology and smart wearable technology with machine learning software offers the opportunity to remotely monitor patients before and after surgery. This provides surgeons, hospitals, and stakeholders the opportunity to objectively quantify (1) patient compliance, (2) value of a given surgical procedure with unprecedented benchmarking, and, more importantly, (3) the better triage of those needing increased perioperative attention. Regardless of the orthopaedic procedure, a motion-based machine learning software application to commercial mobile and wearable technology readily and inexpensively unlocks the potential of delivering value-based care through the low maintenance acquisition of both precision, small data that may then be extrapolated to population-level revelations from big data regardless of the joint or extremity. With the rise of telemedicine, clinical validation of the technology is of mutual interest to orthopaedic patients, surgeons, administrators, payers, and policymakers.
T14, a 14mer peptide, is significantly increased in the pre-symptomatic Alzheimer's disease brain, and growing evidence implies its pivotal role in neurodegeneration. Here, we explore the subsequent intracellular events following binding of T14 to its target α7 nicotinic acetylcholine receptor (nAChR). Specifically, we test how various experimental manipulations of PC12 cells impact T14-induced functional outcomes. Three preparations were compared: (i) undifferentiated vs. NGF-differentiated cells; (ii) cells transfected with an overexpression of the target α7 nAChR vs. wild type cells; (iii) cells transfected with a mutant α7 nAChR containing a mutation in the G protein-binding cluster, vs. cells transfected with an overexpression of the target α7 nAChR, in three functional assays - calcium influx, cell viability, and acetylcholinesterase release. NGF-differentiated PC12 cells were less sensitive than undifferentiated cells to the concentration-dependent T14 treatment, in all the functional assays performed. The overexpression of α7 nAChR in PC12 cells promoted enhanced calcium influx when compared with the wild type PC12 cells. The α7345-348 A mutation effectively abolished the T14-triggered responses across all the readouts observed. The close relationship between T14 and the α7 nAChR was further evidenced in the more physiological preparation of ex vivo rat brain, where T30 increased α7 nAChR mRNA, and finally in human brain post-mortem, where levels of T14 and α7 nAChR exhibited a strong correlation, reflecting the progression of neurodegeneration. Taken together these data would make it hard to account for T14 binding to any other receptor, and thus interception at this binding site would make a very attractive and remarkably specific therapeutic strategy.
PURPOSE: A composition for preventing early dental caries by remineralization of teeth is provided. CONSTITUTION: A composition for coating teeth contains 3-10 weight% of minute hydroxyapatite, 6-15 weight% of binder, 5-10 weight% of sweetener, 20-35 weight% of wetting agent and remaining amount of solvent. The binder is polyethylene glycol or carboy methylcellulose sodium. The solvent is water or alcohol. A composition remineralizes teeth by applying the composition on the teeth for 10 minutes to 10 hours a day. A gum composition contains minute hydroxyapatite, gum base, and additive.