anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present proposal is intended to answer the call for accelerating drug development by exploring the potential of a novel anticonvulsant, Pitolisant as a candidate medication for the treatment of AUD. Pitolisant is an H-3 receptor inverse agonist that is FDA-approved for treating narcolepsy which has been found to have effects of on alcohol craving and consumption in preclinical studies. The aims of this study are to test the effects of Pitolisant on alcohol self-administration and craving among a sample of non-treatment seeking heavy drinkers. The effects of 5-days of pitolisant (8.9mg) or placebo will be evaluated in a human laboratory using an alcohol self-administration methodology. In this within-subjects crossover design, heavy drinkers (N=28) will be randomized to the order of exposure (Pitolisant or placebo) prior to completing two alcohol self-administration trials. Subjects will receive a priming drink of alcohol and will have access to 8 alcoholic drinks over a 2-hour period. The investigators anticipate that subjects will consume less alcohol during an alcohol self-administration trial when receiving Pitolisant compared to when they are receiving placebo. Significant Pitolisant-induced reductions in the quantity of alcohol self-administered will be considered to be an indication that this drug may have value as an AUD medication. This study may provide a rationale for phase II clinical studies testing Pitolisant with a treatment-seeking AUD population.
The invention discloses a nano drug carrier, a preparation method and an application thereof. The nano drug carrier is a mesoporous silicon dioxide composite particular including an inner core, a middle layer and an outer layer. The inner core is a nano mesoporous silicon dioxide particle, the middle layer is arranged on the surface of the inner core and includes at least one self-assembling layer, wherein the self-assembling layer includes Con A and glycogen which are combined with each other, and the outer layer is a transferrin layer which is arranged on the surface of the middle layer. In the invention, a layer-by-layer self-assembling membrane-making technology is employed. At least one Con A-glycogen self-assembled layer is formed on the surface of the nano mesoporous silicon dioxide particle and finally a super-molecular layer-shaped membrane with the transferrin being the outer layer is formed. The nano drug carrier is good in biocompatibility, is simple in preparation method and has a double-characteristic including tumor targeting and stimulative responding.
The invention aims to provide compound synergy tylosin tartrate for veterinary injection and a preparation method thereof. The compound synergy tylosin tartrate for veterinary injection has a quick and exact curative effect on livestock respiratory system infection and complication, and is prepared by the following steps of: mixing and smashing 0.2 parts of trimethoprim and 0.2 parts of cosolvent; sieving through a 120-meshed or finer sieve; and uniformly mixing with 1 part of tylosin tartrate, 1 part of kanamycin sulfate and 0.05-0.1 parts of pain relief agent according to an equivalent progressively increase method. The cosolvent is citric acid or succinic acid or a compound of the citric acid and the succinic acid. The pain relief agent is procaine hydrochloride or lidocaine hydrochloride or a compound of the procaine hydrochloride and the lidocaine hydrochloride. The compound synergy tylosin tartrate for veterinary injection contains three pharmaceutical ingredients, i.e. the tylosin tartrate, the kanamycin sulfate and the trimethoprim, so that the problem that secondary infection cannot be controlled well when mycoplasma infection is treated due to narrow tylosin tartrate antimicrobial spectrum is solved; the problem that the trimethoprim is poorly soluble in water is solved; the tylosin tartrate and the kanamycin sulfate can be synergied; and the medicinal cure effect is obvious.
Fecal immunochemical testing (FIT) is an FDA-approved stool-based screening test for colorectal cancer. It offers a less invasive colorectal cancer screening option for patients who are not agreeable to colonoscopy and measures the level of Ab-globin complexes in the stool without direct interference with diet or medications. FIT has been shown to be selective for colorectal bleeding, as globin from the upper GI tract is digested by proteolytic enzymes. A meta-analysis of studies analyzing FIT showed a pooled sensitivity of 0.79 (95% CI 0.69-0.86) and specificity was 0.94 (CI 0.92-0.95). In a large study comparing FIT with another stool-based screening test, gFOBT, sensitivity of FIT was found to be 0.53-0.73 for CRC and 0.20-0.25 for advanced neoplasia compared to gFOBT, which showed 33.3% for CRC and 8.6% for advanced neoplasia. In addition, FIT requires fewer stool samples and the lack of dietary or medication modifications. As a result, compliance is likely to be higher, which is crucial for cancer detection.

A challenge inherent to stool-based screening tests is compliance with sample submission by the patients. FIT is meant to improve logistical barriers to screening because only one sample is needed, however, compliance rates with standard of care FIT (FIT-SOC) is approximately 50%. FIT using stool from a digital rectal exam (DRE) performed during a clinic visit may be an effective screening tool for patients preferring stool-based screening. FIT has been FDA-approved for the testing of spontaneously passed stool, as well as stool collected by DRE. Manufacturers of FIT have claimed that DRE provides a sufficient amount of stool for sampling, however, there are no validated studies to our knowledge which demonstrate adequate efficacy. As a result, FIT using DRE is not commonly done in clinical practice. This study aims to assess the correlation of FIT using DRE (FIT-DRE) with standard of care FIT (FIT-SOC) as a method of obtaining stool samples.
The invention relates to Chinese herbal medicines, in particular to a traditional Chinese medicine for treating trigeminal neuralgia. The traditional Chinese medicine is characterized by comprising raw gypsum, baikal skullcap root, gardenia, tall gastrodia tuber, rhynohophylla, red peony root, twotooth achyranthes root, rhizoma ligustici wallichii, dahurian angelica root, long pepper, muscardine silkworm, centipede and licorice. Each dose of medicine comprises the following components in weight ratio: 20-30g of raw gypsum, 10-12g of baikal skullcap root, 10-12g of gardenia, 10-15g of tall gastrodia tuber, 20-30g of rhynohophylla, 15-18g of red peony root, 15-18g of twotooth achyranthes root, 15-18g of rhizoma ligustici wallichii, 15-18g of dahurian angelica root, 3-4g of long pepper, 15-20g of muscardine silkworm, 2-3 centipedes and 9-12g of licorice. The whole prescription of the invention exerts the effects of reducing fever, purging the pathogenic fire, calming the liver, relieving convulsion and spasm, promoting blood circulation and relieving pain together. The medicine has simple preparation, low cost, wide medicine source, convenient use, quick curative effect, high cure rate and no any toxic or side effect and can effectively carry out treatment. The effective rate of the clinical application is 90%, and the cure rate is 60%.
Individuals in acute rehabilitation following acquired brain injury journal (ABI) and aged-matched, non-injured controls will be recruited for this study.

Testing sessions will take place in a private treatment room at the Shirley Ryan AbilityLab and required 45 minutes to complete. Upon entering the room, participants will be greeted, electrodes placed on the participant's fingers to record their electrodermal activity, and participants will provide demographic information. Participants will then be instructed about how to respond on the Cued Reinforcement Response Time task (CRRT, see description below), and complete the task on a laptop computer while their electrodermal activity is being recorded. In this task, they are instructed to respond as quickly and accurately as possible, and will be informed that they will receive a monetary reward based on their accuracy at the completion of the task. Finally, participants will complete 3 self-report measures: (1) explicit level of motivation was measured in a post-study survey which included two items from the Sensitivity to Punishment and Sensitivity to Reward Questionnaire, (SPSRQ); (2) Reward sensitivity was evaluated using the Reward Responsiveness Scale , and (3) depression was evaluated using the Patient Health Questionnaire (PHQ-8) survey. At the end of the session, the electrodes will be removed, and participants will be debriefed and provided their monetary reward
Diagnosis of T2DM was made according to the criteria of the American Diabetes Association. All patients were tested by angiography, with CAD diagnosed if luminal diameter narrowing was estimated visually at ≥50% in a major epicardial coronary artery.
The use of an ionic eluent in ion exchange chromatography for analysing a sample comprising an analyte, wherein the ionic eluent comprises a volatile ionic salt, in particular an ammonium salt, is described. Such eluents are shown to be compatible with mass spectrometry (MS), providing clean mass spectra of the analyte. Furthermore, eluates from ion exchange chromatography may be advantageously analysed with MS without additional on-line or off-line devices for desalting or suppressing salts in the eluent. Important information concerning the chemical structure and composition of a sample may therefore be obtained with ion chromatography-MS by utilising the invention. The invention also provides a method of analysing a sample (e.g. a vaccine) comprising an analyte (e.g. a saccharide) by ion chromotography-MS by employing an ionic eluent, wherein the ionic eluent comprises a volatile ionic salt. An apparatus for analysing a sample comprising an analyte is also disclosed.
13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

No evidence of tumorigenicity was observed in a 104-week inhalation study in rats at tiotropium doses up to 0.059 mg/kg/day, in an 83-week inhalation study in female mice at doses up to 0.145 mg/kg/day, and in a 101-week inhalation study in male mice at doses up to 0.002 mg/kg/day. These doses correspond to approximately 25, 35, and 0.5 times the recommended human daily inhalation dose (RHDID) on a mg/m2 basis, respectively. These dose multiples may be over-estimated due to difficulties in measuring deposited doses in animal inhalation studies.

Tiotropium bromide demonstrated no evidence of mutagenicity or clastogenicity in the following assays: the bacterial gene mutation assay, the V79 Chinese hamster cell mutagenesis assay, the chromosomal aberration assays in human lymphocytes in vitro and mouse micronucleus formation in vivo, and the unscheduled DNA synthesis in primary rat hepatocytes in vitro assay.

In rats, decreases in the number of corpora lutea and the percentage of implants were noted at inhalation tiotropium doses of 0.078 mg/kg/day or greater (approximately 35 times the RHDID on a mg/m2 basis). No such effects were observed at 0.009 mg/kg/day (approximately 4 times than the RHDID on a mg/m2 basis). The fertility index, however, was not affected at inhalation doses up to 1.689 mg/kg/day (approximately 760 times the RHDID on a mg/m2 basis). These dose multiples may be over-estimated due to difficulties in measuring deposited doses in animal inhalation studies.

13.2 Animal Toxicology and Pharmacology

Reproductive Toxicology Studies   
No evidence of fetal structural alteration was observed in rats and rabbits at inhalation tiotropium doses of up to 1.471 and 0.007 mg/kg/day, respectively. These doses correspond to approximately 660 and 6 times the RHDID on a mg/m2 basis, respectively. However, in rats, fetal resorption, litter loss, decreases in the number of live pups at birth and the mean pup weights, and a delay in pup sexual maturation were observed at inhalation tiotropium doses of ≥0.078 mg/kg (approximately 35 times the RHDID on a mg/m2 basis). In rabbits, an increase in post-implantation loss was observed at an inhalation dose of 0.4 mg/kg/day (approximately 360 times the RHDID on a mg/m2 basis). Such effects were not observed at inhalation doses of 0.009 and up to 0.088 mg/kg/day in rats and rabbits, respectively. These doses correspond to approximately 4 and 80 times the RHDID on a mg/m2 basis, respectively. These dose multiples may be over-estimated due to difficulties in measuring deposited doses in animal inhalation studies.
The aim of this research was to perform a comparative clinical and histomorphometric analysis of soft tissues in the area of soft tissue graft and collagen matrix transplantation. Thirty five patients diagnosed with partial absence of teeth were examined on the basis of the Department of Surgical Dentistry of the E.V. Borovsky Institute of Dentistry of I.M. Sechenov First Moscow State Medical University. Patients had a soft tissue thickness deficiency from the vestibular surface in the area of the planned dental implant placement which was an indication for its increase. All patients were randomly divided into two groups depending on method of soft tissue augmentation used. In 1 group (n=15) transplantation of a free connective tissue graft (CTG) from tuberosity area of the upper jaw was performed. In 2 group (n=20) collagen matrix "Fibromatrix" was used. According to gender and age characteristics both groups were comparable. Randomization of patients was carried out at the stage of surgical intervention as follows: after a dental implant placement and preparation of recipient's bed an envelope with a randomly assigned treatment method (using a connective tissue graft or a collagen matrix) was opened.

During the operation, incision was made along the top of the alveolar ridge within the defect; a full-thickness muco-periosteal flap was elevated. Traditional 2-stage dental implantation was performed according to surgical protocols of dental implant systems Ostem (Osstem Implant Co., Ltd., Korea; registration in Russia 05.09.2018 No FSZ 2018/7577). A free connective tissue graft was harvested in patients of the first group. Graft was fixed with a horizontal U-shaped suture to the buccal muco-periosteal flap. In second patients group a fragment of the collagen matrix "Fibromatrix" was fixed to the buccal muco-periosteal flap (LLC "Cardioplant", Russia; registration in Russia 20.05.2019 No № FSZ 2019/83671). For patients of all groups mobilization of the muco-periosteal flap conducted followed by suturing the wound tightly without tension with simple interrupted sutures.

In the early postoperative period the standard antibacterial and anti-inflammatory therapy in combination with the use of local antiseptics for daily care was prescribed. The stage of the implant uncovering with hilling abutments installation was carried out 3 months after the intervention. At this stage, a soft tissue fragment was taken using a mucotome in the area of the previously performed mucous membrane thickness increasing for subsequent histomorphometric analysis. In the study we used both conventional light microscopy (microscopy in the light field) and polarizing microscopy - to estimate the content of collagen fibers in preparations stained with picrosirius red. During a morphometric study we carried out a quantitative assessment of the characteristics of the epithelial layer, the basement membrane relative length (the ratio of the absolute length of the basement membrane to the length of the epithelial layer), the characteristics of the underlying connective tissue.
<P>PROBLEM TO BE SOLVED: To provide a liquid filter apparatus capable of automating liquid filtering operation to efficiently perform the same.  <P>SOLUTION: The first member 15, on which a container 8 with a filter being a microtiter plate wherein a filter part is provided on the bottom part of a well is placed, is lowered with respect to the second member 11 having a recovery container 9 mounted therein. A hermetically closed space 3a is formed by the first and second members 15 and 11 and the container 8 with the filter. At the time of filtering operation of a liquid, the nozzle 18 of a dispensing head 17 is lowered to supply a treated liquid 6 into the well of the container 8 with the filter and the hermetically closed space 3a is sucked under vacuum by the suction part 43 to suck the treated liquid in the well from the filter part to drip a liquid component to the recovery container 9. By this constitution, liquid filtering operation can be automated to be performed efficiently.  <P>COPYRIGHT: (C)2004,JPO
The invention discloses a methyl vinyl ether and maleic acid copolymer/chondroitin sulfate-based pH-sensitive composite hydrogel and a preparation method thereof. The pH-sensitive composite hydrogel is a reticulate structure. The polymer rhydrogel is obtained through chemically cross-linking an artificially synthesized polymer with a natural polymer chondroitin sulfate by adopting adipic dihydrazide with 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide as catalysts. The method has the advantages of simple synthesis process, mild reaction conditions, and suitableness for large-scale production. The hydrogel is prepared from the artificially synthesized polymer P(MVE-alt-MA) and the natural polymer Chs, and mechanical performances of the hdyrogel can be easily adjusted through adjusting the ratio of the artificially synthesized polymer to the natural polymer, so the method can easily meet application demands and industrial production. The hydrogel disclosed in the invention has pH sensitivity, and has good application prospect in the fields of drug sustained release and tissue engineering scaffolds.
The invention relates to a nanometer selenium-VE (vitamin E) anti-wrinkle skin-smoothing cream, belonging to the technical field of production and preparation of cosmetic skin tenderization series products. With the ageing of population in China, the behaviors of anti-aging, anti-wrinkle, hairdressing and skin care are paid attention and cared. The common medical discipline shows that the active material for people to resist the aging is used for cleaning free radicals. The free radicals continuously generated in normal metabolism of a human body promote the aging; and air pollution, sunlight ultraviolet radiation and excess cigarettes and drinks cause the aging, and 100,000 free radicals are generated at each whiff of cigarette. Excess free radicals catalyze the aging of the human body. Selenium, specifically nanometer selenium, has a strong effect on eliminating the free radicals; the activity of nanometer selenium for cleaning free radicals is improved by five times compared with that of organic selenium, therefore, the key point of the invention is that the nanometer selenium and VE are added in the skin-smoothing cream.
A physical distribution system for distributing prescribed medications ordered by physicians from a storeroom via a pharmacy to patients in a hospital department in a secure and reliable manner. The physical distribution system comprises a container with compartments, and dispensers. Each of the compartments is associated with an electronic lock associated with an opening code uniquely associated with a physician, a patient and prescription data. Each of the plurality of dispensers is associated with a unique patient related code. Each electronic lock is arranged to enable entering the prescribed medications into the associated compartment upon identification of the associate opening code. Each electronic lock is arranged to enable disposing prescribed medications from compartments into the dispenser upon identification of a patient related code on the dispenser corresponding to patient data in the opening code. The prescribed medications are associated with their prescription data.
The goal of this pilot study is to collect preliminary data that will allow the investigators to formulate theories about ER-related brain function change during intervention-like training that will be tested in larger, externally-funded grant proposals submitted to the National Institutes of Health. The investigators are not especially interested in any existing specific, manualized therapeutic technique. Existing ER-based psychotherapies typically incorporate a variety of related interventions, not all of which focus on the ER component itself. Instead, the investigators will focus on the "building blocks" of such therapies, i.e., the ER interventions themselves and their effect on negative emotional reactions. Here, the investigators ask a specific question - How does ER-elicited brain function change with repeated sessions of guided practice of various ER techniques? In other words, does increasing familiarity or mastery of ER skills through practice change brain function, and how? There are logical hypotheses about the likely nature of brain function changes that can be gleaned from prior neuroimaging research. For instance, if prefrontal cortex activation is important to ER, perhaps practice simply increases such activation. However, pilot work for the current NIMH R01 suggests instead that ER practice might work by enhancing the functional integration among key frontolimbic regions. Complicating such hypotheses is the recognition that different ER tactics engage many distinct brain regions depending on which approach is employed. So a participant's individual brain function differences prior to ER training might be a potent determinant for what sorts of neural changes result from repeated practice. Because all these issues must be evaluated through the lens of a preliminary study before any coherent theoretical model can be formulated, a pilot study is proposed here. Not only will this provide empirical data upon which to base future research, conducting such a pilot will showcase any methodological hurdles or challenges that need to be overcome in order to successfully conduct a larger-scale study.
BACKGROUND AND AIMS: Insulin resistance (IR) has previously been associated with hypertension, and obesity is a risk factor for IR and hypertension. There is likely an association between body mass index (BMI) and risk for hypertension through the triglyceride-glucose (TyG) index but this relationship remains uncharacterized.
METHODS AND RESULTS: This study is based on the Hanzhong Adolescent Hypertension Cohort, which is an ongoing prospective study established in 1987. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. The total area under the curve (AUCt) and incremental AUC (AUCi) were calculated as the long-term burden and trend of BMI, respectively. We found that BMI AUCt and BMI AUCi were significantly associated with the risk of adult hypertension, both without (RR = 1.30/1.31 for BMI AUCt/AUCi) and with (RR = 1.25/1.26 for BMI AUCt/AUCi) the inclusion of the TyG index as a covariate. Importantly, mediation analysis revealed that the TyG index mediated the BMI AUCt-SBP association (19.3%), the BMI AUCt-DBP association (22.7%), the BMI AUCi-SBP association (18.5%) and the BMI AUCi-DBP association (21.3%). Furthermore, the TyG index had a significant mediating effect of 15.9% on the BMI AUCt-hypertension association and 14.9% on the BMI AUCi-hypertension association.
CONCLUSION: These findings suggest that the TyG index plays an important mediating role in the association between the cumulative burden and increasing trends of BMI originating in childhood and the risk of hypertension in midlife. We emphasize that early weight management has the potential to reduce the burden of hypertension caused by IR.
TRIAL REGISTRATION: The study was clinically registered at the ClinicalTrials.gov (NCT02734472) and approved by the Academic Committee of the First Affiliated Hospital of Xi'an Jiaotong University (XJTU1AF2015LSL-047).