anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The investigators have previously generated estimates for cost effectiveness of each arm of this reciprocal screening protocol based on literature dervied estimates of coprevalence and other key factors in a decision tree model to compare costs and outcomes. They measured expected outcomes using quality-adjusted life years (QALY) and the incremental cost-effectiveness ratios (ICER). The current study will involve establishment of the true co-prevalence and recalculation of the ICERs and QALYs. Based on their literature derived models we previously found an ICER of $34.01/QALY for AAA screening in IA patients and an ICER of $6,401.91/QALY for IA screening in AAA patients. Both of these are well below the societal accepted threshold of $60,000/QALY. However, both models were sensitive to co-prevalence. In the current study the investigators will therefore determine the actual cost-effectiveness of performing additional radiographic procedures and genetic counseling. The investigators will also bank DNA and RNA for future research.
The invention relates to actinolite pill integrative new formulation preparation technology and a production method thereof; the effective components comprise the following raw materials by weight: 2 parts of actinolite, 3 parts of fructus evodiae, 1 parts of prepared rehmannia roots, 3 parts of achyranthes roots, 3 parts of dried ginger, and 3 parts of bighead atractylodes rhizome. The production process comprises: ultrasonic jet milling, alcohol water extraction, ultrasonic crushing extraction, water decoction concentration, ultrasonic spray drying, nanometer grinding, high pressure homogenization, nanoparticle preparation, and the like. The invention emphasizes the utilization of the advantages of multiple synergism and multiple targeting of nanometer carrier combination technology. After large-scale production, the production cost is greatly reduced; the product quality is greatly improved; and the medicament targeting and sustained and controlled release performance are stronger. Both internal and external administration can be employed, and administration can be performed at four time periods respectively based on meridian flowing and human body qi-blood flowing rules. Film agents and transdermal agents can be prepared, respectively pasted at different parts of human body based on meridian flowing and human body qi-blood flowing rules, and directly absorbed through skin.
PURPOSE: Previous research highlights the adverse effects of visual impairment (VI) on academic achievement in children, yet its impact on cognitive performance among adolescents and young adults remains under-studied. Therefore, this investigation aimed to analyse this association in a nationwide sample of Israeli adolescents.
METHODS: A retrospective population-based cross-sectional study was conducted among 1,410,616 Israeli-born adolescents aged 16-19 years, who were assessed before mandatory military service between 1993 and 2017. The definition of VI was based on best-corrected visual acuity (BCVA) measurements using a standard Snellen chart. Adolescents with BCVA worse than 6/9 in either or both eyes were classified as having unilateral or bilateral VI, respectively. Cognitive performance was measured using the General Intelligence Score (GIS), based on a validated four-domain test. Relationships were analysed using regression models yielding adjusted odds ratios (ORs) for low (<-1 standard deviation [SD]) and high (≥1 SD) cognitive Z-scores.
RESULTS: Of 1,410,616 adolescents (56.1% men), 13,773 (1.0%) had unilateral and 3980 (0.3%) had bilateral VI. Unilateral VI was associated with adjusted ORs for low and high cognitive Z-scores of 1.24 (1.19-1.30) and 0.84 (0.80-0.89), respectively. ORs were accentuated for bilateral VI, reaching 1.62 (1.50-1.75) and 0.81 (0.74-0.90) for low and high cognitive Z-scores, respectively. Cognitive performance subscores mirrored these results, with the visual-spatial functioning subtest demonstrating the greatest effect size. These associations persisted in sub-analyses restricted to adolescents with amblyopia-related VI, mild VI and unimpaired health status.
CONCLUSIONS: Visual impairment, including mild and unilateral cases, is associated with reduced cognitive performance scores assessed in late adolescence. Further research is required to gain a comprehensive understanding of the dynamics underlying this relationship.
This is an open label, phase 1 dose escalation study designed to establish the safety and RP2D of autologous BAFF CAR-T cells in adults with refractory SLE. The planned dose escalation includes 3 dose levels and one de-escalation level. The maximum tolerated dose (MTD) will be determined using a 3+3 dose escalation design. The MTD dose level cohort may be expanded to a total of 6 patients. RP2D may be selected at dose level(s) at or below the MTD based on all data then available (e.g. efficacy, safety, PK and PD), and additional patients enrolled at these levels to expand up to a total of 40 patients in the study, in order to further evaluate safety and efficacy and guide Phase 2 trial design.

To ensure patient safety, during dose escalation, treatment of subjects at each dose will be staggered by at least 14 days. For example, the second subject will be enrolled only after the first subject has finished 14 days of safety monitoring from the CAR-T cell infusion, and the third subject will be enrolled only after the second subject has finished 14 days of safety monitoring from the CAR-T cell infusion. In the expansion cohorts, this staggering interval will no longer be required.
The central question of nephron-sparing surgery in unilateral non-syndromic Wilms tumour sits at a crossroads between surgery, oncology, and nephrology. There has been a significant paradigm shift in paediatric oncology towards reducing toxicity and addressing long-term treatment-related sequalae amongst childhood cancer survivors. After paediatric nephrectomy and 30-50 years of follow-up, 40% of patients will have chronic kidney disease, including 22% with hypertension and 23% with albuminuria. It is difficult to predict which patients will progress to develop hypertension, reduced glomerular filtration rate, albuminuria, and a higher cardiovascular risk. For these reasons, nephron-sparing surgery when it is technically feasible must be considered. To decrease the incidence of positive surgical margins (viable tumour present at a resection margin), incomplete lymph node sampling, and complications, these procedures should be performed at specialist and experienced reference centres. Based on the impacts of individual treatment pathways, survivors of childhood WT need to be followed through adulthood for early detection of chronic kidney disease, hypertension, and prevention of cardiovascular events.
A medical network system includes a computed tomography apparatus for imaging a body to acquire plural tomographic medical images as data files. An image server processes an image group of the tomographic medical images transferred from the computed tomography apparatus by network transmission. In the computed tomography apparatus, an imaging number of a sequence of imaging of each of the tomographic medical images is generated. An image end flag is generated, and represents a final tomographic medical image acquired finally in the image group. The image server includes CPU for checking the imaging number and the image end flag and for verifying completion of transfer of the tomographic medical images in the image group. The image server includes a site recognition unit for recognizing a site of the body recorded in each of the tomographic medical images by image recognition, to create site information.
Medicinal products are obtained by triturating plants or parts thereof in the freshly gathered state in the presence of amyloses such as starch, dextrin and polyamyloses and then drying the trituration at a temperature not above 30 DEG  C., the moisture content of the air preferably decreasing.  Buffer salts &c. having an alkaline reaction may be added before drying.  According to examples, mentha piperita plants are triturated with sugars and amylose. According to the Specification as open to inspection under Sect. 91, the presence of amyloses in making the triturations is not essential, the use of sugars not crystallizing or crystallizing with difficulty is described and also of amorphous bodies such as tragacanth and pectin.  Examples describe triturations of inula-helenium, thuja, juniper berries and pinus sylvestris.  This subject-matter does not appear in the Specification as accepted.
Participants receive 15 Real (active) LED treatments with the Vielight Neuro Alpha head frame device (with intranasal). Parameters: NIR, 810nm, pulsed at 10 Hz, 50% duty cycle, synchronized for a 20-minute treatment time. Total Energy Dose per head set plus intranasal: 225 J/cm2+ 15 J/cm2 = 240 J/cm2 per 20 min LED treatment. Total Energy Dose delivered (3x/Week, 5 Weeks) = 3600 J/cm2. The light from these LEDs is not visible to the eye. There is no potential for eye damage because the LEDs are not laser light. The head frame device falls within the FDA category General Wellness, low-risk devices, and no medical claims are made. It is approved for use by the VA Boston Healthcare System Safety Committee and Institutional Review Board.
PURPOSE: A pharmaceutical and cosmetic composition containing benzoyl chitosan is provided to adsorb with various injury healing factors and to improve stability of the factors. CONSTITUTION: A composition for injury healing contains a compound of chemical formula 1 as an active ingredient. The skin injury includes burn, ulcer, trauma, post-surgical, birth, chronic wound or dermatitis. The burn includes sun, chemical, radiation, or heat. The composition is used for topical application on skin. The composition is a pharmaceutical, functional cosmetics, or cosmetic composition.
The invention discloses a 3,4-dibenzamido benzamide derivative (I), wherein R1, R2 and R3 are respectively and individually hydrogen, fluorine, chlorine, bromine, hydroxyl groups, alkoxy groups, amino groups or substituted amino groups. The alkoxy groups are a C1-C4 alkoxy groups. The substituted amino groups include amino-NR5R6, acylamino-NHCOR7 and sulfoamino-NHSO2R8. The R5, R6, R7 and R8 are respectively and individually C1-C4 alkyl groups and C1-C4 halogenated alkyl groups. The R4 is a five-membered to seven-membered N-heterocyclic group. The invention also discloses a preparation method of the compound, and an application of the compound as an FXa inhibitor in preparation of medicines for preventing or treating cardiovascular and cerebrovascular diseases.
The purpose of this study is to test the safety of a new medicine called antibody 8H9 injected into the lining of the abdomen or peritoneum, where the tumor is. This medicine is an antibody or protein which binds to certain tumors, including DSCRT. There is a small number of DSCRT which do not bind with 8H9. If the tumor does not bind with 8H9, you might not benefit from this treatment. The investigators want to find out what effects, good and/or bad, it has.

This antibody is made in mice. Radioactive iodine can be bound to this antibody to deliver radiation to the tumor. The investigators wish to determine the safety of radiolabeled 8H9 at different dose levels. This is the first study using 131I-8H9 in the peritoneum.
This study will be conducted using a randomized, crossover design with three dietary phases: 1) fine emulsion beverage (small lipid droplet size), 2) coarse emulsion beverage (large lipid droplet size) and 3) non-emulsified oil and water. All treatments will be consumed together with bread. All participants will be randomly allocated to the three test meals. Fifteen to twenty participants aged between 21 and 50 years will be recruited from the general public in Singapore.

During the testing sessions, participants' glycemic, insulinemic, lipidemic responses and gastric emptying to the test meals will be measured. Gastric antral distention ultrasound measurement is an indirect measure of gastric emptying rate. Participants' metabolic satiety for the test meals will also be assessed at regular intervals throughout the testing session. Each testing session will take approximately four hours in duration and the testing sessions will take place at least five days apart.
FIELD: medicine (phthisiology) chemical and pharmaceutical industry, and veterinary science. SUBSTANCE: described is antitubercular agent which is essentially isoniazid- dextran conjugate with molecular weight of 65-75 kD of formula:   wherein R 1  is H, glucose residue or polyglucosyl residue of species shown in Fig. 1; R 2  is isonicotinoyl hydrazide (isoniazid) residue of formula:   or hydroxyl group. Agent has greater prolongation, higher therapeutic efficiency both with respect to micobacteria circulating in blood and micobacteria persisting in granulates, and is substantially less toxic. EFFECT: improved properties of the title agent. 3 cl
Scarring is an inevitable outcome of surgical manipulation of the skin. Previous studies have shown that postoperative scarring, especially in cosmetically sensitive areas, may negatively affect patient quality of life and social interactions. The impact of surgical scarring is magnified in Mohs micrographic surgery, for which the large proportion of treated lesions are in highly visible areas, such as the head, face, and neck. Clinicians often underestimate the significance of scarring in patients' daily activities. Patients desire quick healing surgical scars in order to reintegrate into their normal social routines. Anecdotal evidence suggests that scars that heal well early in the post-operative period will achieve better results in the late postoperative period. Determining a model of early and late surgical scar evolution, as rated by patients, physicians, and third-party observers may; 1. Identify gaps between physician and patient evaluations; 2. Assist clinicians in effectively evaluating and counseling patients regarding their post-operative scar appearance.
PURPOSE: Article-noun disagreement in spoken language is a marker of children with developmental language disorder (DLD). However, the evidence is less clear regarding article comprehension. This study investigates article comprehension in monolingual Spanish-speaking children with and without DLD.
METHOD: Eye tracking methodology used in a longitudinal experimental design enabled the examination of real time article comprehension. The children at the time 1 were 40 monolingual Spanish-speaking preschoolers (20 with DLD and 20 with typical language development [TLD]). A year later (time 2), 27 of these children (15 with DLD and 12 with TLD) were evaluated. Children listened to simple phrases while inspecting a four object visual context. The article in the phrase agreed in number and gender with only one of the objects.
RESULT: At the time 1, children with DLD did not use articles to identify the correct image, while children with TLD anticipated the correct picture. At the time 2, both groups used the articles' morphological markers, but children with DLD showed a slower and weaker preference for the correct referent compared to their age-matched peers.
CONCLUSION: These findings suggest a later emergence, but a similar developmental trajectory, of article comprehension in children with DLD compared to their peers with TLD.
PURPOSE:To obtain a lip cosmetic having excellent durability, keeping high luster of lip without causing chapping of lip and having excellent safety, by using a solid oil component, a liquid oil component and mica powder as essential components and compounding the components at specific ratios. CONSTITUTION:The objective cosmetic is composed of 15-30wt% solid oil, 50-70wt% liquid oil, 5-25% mica powder having an average particle diameter of 0.5-20mu and other colorant. The solid oil is e.g. microcrystalline wax, polyethylene wax, etc., used as a component of lipstick, etc., and the liquid oil component is cetyl 2-ethylhexanoate, squalane, etc., which exhibits fluid liquid state at normal temperature and is used as a component of a lip cosmetic such as lipstick. The mica powder has a composition of hydrated aluminum potassium silicate and the colorant is pearlescent powder such as titanium mica, white, inorganic or organic pigment or dye. EFFECT:Free from stickiness and excellent spreadability.
BACKGROUND: Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field.
METHODS: We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method.
RESULTS: A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years.
CONCLUSION: We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.
Group 1 (G1)- 80 eligible participants will receive training in Cognitive Restructuring (CR). These participants will use CR while receiving rTMS over their individual dlPFC target and will partake in short term and long term follow up testing.
Sciatica and low back pain are common problems that lead to major costs in Western countries. The presence of herniated disc is generally considered as the leading cause of sciatica. However, recent findings indicate that the presence of this mechanism is not sufficient to explain all the clinical signs of radiculopathy and that inflammatory mechanisms contribute also to the pathophysiology of sciatica. Indeed, herniated discs contain large amounts of tumor necrosis factor (TNF-alpha) which can induce acute and chronic inflammation and pain. It has recently been demonstrated that TNF-alpha inhibitors (infliximab or etanercept) were able to prevent the occurrence of pain in an experimental model of sciatica. In addition, two independent preliminary studies have shown that patients treated with TNF-alpha inhibitors had better evolution than an historical control group. This study has been designed to verify the hypothesis that TNF-alpha has a major role in human sciatica and that anti-TNF-alpha agents are interesting therapeutic approaches in severe sciatica.
Patients will be vaccinated once a week for four weeks of a treatment cycle. On each vaccination day, the HLA-A\*0201 or HLA-A\*0206-restricted URLC10 peptide (2mg) mixed with Montanide ISA 51 will be administered by subcutaneous injection.
Mitochondrial respiration and metabolism play a pivotal role in facilitating the migratory and invasive capacities of cancer cells. In this study, we aimed to explore the potential influence of glycoprotein SPARC on mitochondrial respiration and its subsequent influence on the migration and invasion of hepatocellular carcinoma (HCC) cells. Lentivirus-mediated shRNA delivery was employed to deplete SPARC in HCC cell lines. The mitochondria localization of SPARC was validated using cellular fractionation followed by Western blot analysis, as well as immunofluorescence staining and Proteinase K protection assay. Co-immunoprecipitation was employed to investigate the interaction between SPARC and GPD2. Seahorse XF Cell Mito Stress Test was conducted to assess the mitochondrial respiration and functionality of HCC cells. Our study identifies an active pool of SPARC within the mitochondria of HCC cells, with the mitochondrial subset proving crucial for the regulation of migration and invasion. The mitochondrial SPARC interacts with GPD2, influencing its expression levels and subsequently modulating GPD2-mediated mitochondrial respiration. This regulatory mechanism orchestrates the migratory and invasive phenotypes of HCC cells. Notably, SPARC and GPD2 exhibit upregulated expression in HCC tissues compared to normal liver tissues. High expression levels of both SPARC and GPD2 in HCC patients are associated with a poorer prognosis. Our study unveils a novel role for SPARC in governing HCC cell migration and invasion through regulating GPD2-mediated mitochondrial respiration. These findings underscore the importance of mitochondrial processes in cancer progression and propose the SPARC/GPD2 axis as a promising target for HCC interventions.
PURPOSE: A medical device and a medical image display method using the same are provided to directly confirm an image having a lesion without reading the image from the beginning. CONSTITUTION: A medical device (3) includes a display unit (4), a communication unit (21), an input unit (22), and a control unit (23). The communication unit receives various information for the diagnosis of medical staff or an inner image of an object from a server (2) and transmits information modified or manipulated in the medical device to the server. When the communication unit receives image information of the object, the control unit displays an image having an unusual image on the display unit. The control unit displays the object linked with the image having the unusual image on the display unit. [Reference numerals] (14) Internet; (2) Server; (21) Communication unit; (22) Input unit; (23) Control unit; (3) Medical device; (4) Display unit
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition comprising enalapril maleate as an active compound and lactose, starch, polyvinylpyrrolidone, calcium or magnesium stearate and talc as accessory inert substances taken in the definite amounts. Method for preparing enalapril maleate base-pharmaceutical composition as a tablet involves wetting granulation of tabletted mass with the combined wetting agent. Wetting agent comprises 2-4% solution of starch sizing and 15-20% polyvinylpyrrolidone an aqueous solution. Pharmaceutical solid composition based on enalapril maleate satisfies to all requirements of the pharmaceutical standard by indices of decomposition, solubility and stability at storage. The use of polyvinylpyrrolidone aqueous solution as component of the combined wetting agent provides the decreased cost of tablets. EFFECT: improved preparing method, valuable pharmaceutical properties of composition. 4 cl, 1 ex
Patients receive cisplatin and undergo radiotherapy as in arm I. Patients also receive cetuximab IV over 1 hour once weekly during weeks 1-6.