anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Chronic rhinosinusitis (CRS) is a complex inflammatory condition affecting the nasal and paranasal sinus mucosa. Gastroesophageal reflux disease (GERD) has been implicated as a potential exacerbating factor in CRS, but the specific endoscopic features of nasopharyngeal pathology in this context remain poorly understood. Background and Objectives: Chronic rhinosinusitis is a multifactorial disease with various underlying etiologies, including inflammation, anatomical factors, and environmental triggers. While gastroesophageal reflux disease has been suggested as a potential contributor to chronic rhinosinusitis, the specific endoscopic features indicative of nasopharyngeal pathology in CRS patients with GERD symptoms have not been clearly elucidated. Our aim is to identify specific endoscopic features of nasopharyngeal pathology in patients with CRS associated with GERD symptoms and to propose a method for assessing the influence of gastroesophageal reflux disease on the mucosal layer of the nose and nasopharynx. Materials and Methods: We conducted a cross-sectional observational study involving 521 adult patients presenting with symptoms suggestive of CRS. From this cohort, 95 patients with the highest scores on the Reflux Symptom Index (RSI) and Reflux Symptom Score-12 (RSS-12) questionnaires were selected as the main group. Endoscopic examinations were performed to assess the nasal and nasopharyngeal mucosa. Results: Our study revealed significant alterations in the nasopharyngeal mucosa of patients with CRS associated with GERD symptoms. Increased vascularity of the nasopharyngeal mucosa was observed in 91 patients (95.7%), while hypertrophy was noted in 83 patients (87.4%). Mucus was present in the nasopharynx of 77 patients (81.1%), exhibiting varying characteristics of color and consistency. Asymmetric hypertrophy of the oropharyngeal mucosa was noted in 62 patients (65.3%). Conclusions: We propose a method for assessing the influence of gastroesophageal reflux disease on the mucosal layer of the nose and nasopharynx, which may aid in diagnostic and management decisions. Further research is warranted to explore the potential impact of GERD symptoms on the course and severity of CRS exacerbations.
PROBLEM TO BE SOLVED: To obtain an immunopotentiative agent high in immunopotentiation potency, capable of manifesting more potent activity by concurrent use with another immunopotentiative substance, having no adverse effect, and capable of being utilized for a food. SOLUTION: This immunopotentiative agent contains sugars containing 3-O-α- D-glucopyranosyl-D-glucose as a structural unit, e.g. nigerose, nigerantetrasaccharide and nigerotriose as an active ingredient. By blending with a conventional food, a food component, a medicinal carrier or an excipient, the agent can be prepared as a solid or a liquid form. Especially, this immuno- potentiative agent can be used for manifesting lymphocyte co-stimulating actions, especially a T-lymphocyte co-stimulating action and a B-lymphocyte co- stimulating action. As the amount of a does as an oral medicine, 4mg-40mg daily is administered for an adult as the active ingredient by dividing one to several times.  As the food, it can be prepared to the forms of a seasoning material, a processed meat, a processed fishery product, a processed agricultural product, a staple. a pre-cooked food, a seasoned food, desserts, a milk and oil product, a confectionery, etc.
Steroidal and non-steroidal glycosides and a method of producing them are provided, wherein aglycon compounds are glycosylated with tri-O-acyl glucal using molecular or ionized halogen as reaction catalyst. The aglycon, which may be a non-steroid or a steroid having a reactive functional group (e.g., -OH, -SH, -COOH, -NH2, -NHR1) such as a cholesterol, is glycosylated, wherein the glycosylation is performed in a single step. For example, a steryl pyranoside is oxidized to the corresponding 7-ketosteryl di-O-acyl-pyranoside, which is selectively reduced to provide the corresponding 7-beta-hydroxysteryl 2,3-dideoxy-alpha-D-erythro-hex-2-enopyranoside. These steroidal and non-steroidal glycosides possess valuable pharmacological properties. In particular, the cholesterol glycoside exhibits a selective cell-destructive activity on malignant cell, in vivo, and is substantially free of side effects on normal cells. The glycosides possess useful pharmacological properties which are the same as their respective unglycosylated aglycons, which properties include a drive-enhancing (stimulating) activity and an anti-inflammatory (immunosuppressive or immunoregulatory) activity.
BACKGROUND: One of the most prevalent unmet needs among cancer patients is the fear of disease progression (FoP). This cross-sectional study aimed to identify the relationships among uncertainty in illness (UI), intolerance of uncertainty (IU), and FoP among newly diagnosed cancer patients and to verify the mediating role of IU in the relationship between UI and FoP.
METHODS: A total of 202 newly diagnosed cancer patients (male: 105, 51.98%; mean age: 47.45 ± 14.8 years; lung cancer: 49, 24.26%) were recruited by convenience sampling. The patients completed a homemade questionnaire that assessed demographic characteristics, the Fear of Progression Questionnaire-Short Form, the Mishel Uncertainty in Illness Scale, and the Intolerance of Uncertainty Scale.
RESULTS: The prevalence of FoP among newly diagnosed cancer patients was 87.62%, and the prevalences of high, medium, and low levels of UI were 15.84%, 73.27%, and 10.89%, respectively. The mean score on the Intolerance of Uncertainty Scale was 41.19 ± 10.11. FoP among newly diagnosed cancer patients was positively correlated with UI (r = 0.656, P < 0.001) and IU (r = 0.711, P < 0.001). Moreover, IU was positively correlated with UI (r = 0.634, P < 0.001). IU partially mediated the effect of UI on FoP, accounting for 47.60% of the total effect.
CONCLUSIONS: Newly diagnosed cancer patients have a high prevalence of FoP. UI can directly or indirectly affect FoP through the mediating role of IU. Healthcare professionals can help newly diagnosed cancer patients mitigate their FoP by reducing IU in light of UI.
The invention relates to an inhaler (10) with an evaluation unit (60) and also to the evaluation unit (60) on its own. The inhaler (10) has in the conventional way a housing (20) with a mouthpiece (22) and a chamber (12) in which there is a container unit (50), which can be pressed down for the purpose of dispensing medium. Provided between the container unit (50) and a wall (24) of the chamber (12) is an annular gap (14), through which air is sucked in and mixes with the medium flowing out through a discharge opening (32). The evaluation unit (60) is mounted on the container unit (50). It can be pressed down together with a container (52) of the container unit (50) and is designed for detecting the air sucked in through the annular gap (14). For this, it comprises a measuring channel (70), which forms part of a first flow path (100) for air flowing into the open end of the chamber from a surrounding area and which has a flow sensor (94) for detecting the air flowing through the measuring channel (70). In addition to the first flow path, a second flow path (110) is provided for air flowing into the open end of the chamber from a surrounding area, the flow resistance of which second path is equal to or lower than that of the first flow path (110).
This study sample will include 306 Veterans with fibromyalgia. Patients will be randomized to one of two treatment arms. The YOGA arm will involve a standardized 12-week, yoga-based intervention. The yoga intervention will consist of three treatment components: 1) in-person group yoga taught by a certified yoga therapist; 2) a relaxation audio recording for home-use; and 3) a DVD recording to reinforce concepts taught during in-person yoga sessions. Patients randomized to the structured exercise program (SEP) arm will participate in a 12-week exercise program delivered in a group/class format and supervised by a fitness instructor. In addition, SEP patients will receive a DVD (for home use) describing the benefits of aerobic exercise for fibromyalgia, a one-on-one consultation session with the fitness instructor, an individualized exercise prescription, and supervised exercise sessions for 12 weeks.
PURPOSE: A healthy diet reduces the risk of non-alcoholic fatty liver disease (NAFLD) in the general population, especially in individuals who are genetically predisposed to NAFLD. Little is known in patients who suffered from a myocardial infarction (MI). We examined the interaction between diet quality and genetic predisposition in relation to NAFLD in post-MI patients.
METHODS: We included 3437 post-MI patients from the Alpha Omega Cohort. Diet quality was assessed with adherence to the Dutch Healthy Diet index 2015 (DHD15-index). A weighted genetic risk score (GRS) for NAFLD was computed using 39 genetic variants. NAFLD prevalence was predicted using the Fatty Liver Index. Prevalence ratios (PR) with 95% confidence intervals of DHD15-index and GRS in relation to NAFLD were obtained with multivariable Cox proportional hazards models. The interaction between DHD15-index and GRS in relation to NAFLD was assessed on an additive and multiplicative scale.
RESULTS: Patients had a mean age of 69 (± 5.5) years, 77% was male and 20% had diabetes. The DHD15-index ranged from 28 to 120 with a mean of 73. Patients with higher diet quality were less likely to suffer from NAFLD, with a PR of 0.76 (0.62, 0.92) for the upper vs lower quintile of DHD15-index. No association between the GRS and NAFLD prevalence was found (PR of 0.92 [0.76, 1.11]). No statistically significant interaction between the DHD15-index and GRS was observed.
CONCLUSION: In Dutch post-MI patients, adherence to the Dutch dietary guidelines was associated with a lower prevalence of NAFLD, as assessed by the FLI. This association was present regardless of genetic predisposition in this older aged cohort.
Double blinded placebo/Sildenafil crossover design for 6 months with crossover at month 3. Then open label Sildenafil from months 6-12.
ARDSNet protocol (low PEEP-FiO2 table). Ventilatory mode: volume-controlled ventilation Tidal volume (VT) will be adjusted to 4-6 mL/Kg of PBW and Plateau pressure \< 30 cmH2O for the at least the first 12 hours after inclusion in the protocol pH should be maintained between 7.35-7.45 Oxygenation (SpO2) target ranges 90-95% Maximum respiratory rate = 35 breaths/min PEEP and FIO2 adjusted according to the low PEEP-FiO2 Table.
Vatiquinone, a 15-lipoxygenase inhibitor, is in development for patients with Friedreich ataxia. The study determined the effect of vatiquinone on electrocardiogram parameters. This was a 2-part, single-center, randomized, double-blinded, and placebo-controlled study. Part 1 used an adaptive approach to identify a supratherapeutic dose, while Part 2 evaluated the effect of vatiquinone on Fridericia corrected QT interval (QTcF). A safe and tolerated supratherapeutic dose of 1400 mg was identified. Concentration-QTcF analysis confirmed there was no statistically significant relationship between vatiquinone concentration and QTcF. QTcF effect (ie, ΔΔQTcF) exceeding 10 milliseconds was excluded for concentrations up to approximately 11,500 ng/mL. By-time-point analysis confirmed that least-squares mean ΔΔQTcF was below 10 milliseconds. Largest least-squares mean ΔΔQTcF of 1.5 milliseconds was observed at 2 hours after dosing. Vatiquinone did not have a clinically relevant effect on heart rate nor on cardiac conduction (PR interval and QRS interval). No new safety signals were found, as safety data are consistent with the known safety profile of vatiquinone. These findings altogether demonstrated that there is a minimal cardiac risk for vatiquinone concentrations up to the supratherapeutic dose level.
Fifteen healthy volunteers. Each participant will attend for a single study visit, lasting approximately 1 hour in duration.
BACKGROUND: Previous models for predicting delirium after cardiac surgery remained inadequate. This study aimed to develop and validate a machine learning-based prediction model for postoperative delirium (POD) in cardiac valve surgery patients.
METHODS: The electronic medical information of the cardiac surgical intensive care unit (CSICU) was extracted from a tertiary and major referral hospital in southern China over 1 year, from June 2019 to June 2020. A total of 507 patients admitted to the CSICU after cardiac valve surgery were included in this study. Seven classical machine learning algorithms (Random Forest Classifier, Logistic Regression, Support Vector Machine Classifier, K-nearest Neighbors Classifier, Gaussian Naive Bayes, Gradient Boosting Decision Tree, and Perceptron.) were used to develop delirium prediction models under full (q = 31) and selected (q = 19) feature sets, respectively.
RESULT: The Random Forest classifier performs exceptionally well in both feature datasets, with an Area Under the Curve (AUC) of 0.92 for the full feature dataset and an AUC of 0.86 for the selected feature dataset. Additionally, it achieves a relatively lower Expected Calibration Error (ECE) and the highest Average Precision (AP), with an AP of 0.80 for the full feature dataset and an AP of 0.73 for the selected feature dataset. To further evaluate the best-performing Random Forest classifier, SHAP (Shapley Additive Explanations) was used, and the importance matrix plot, scatter plots, and summary plots were generated.
CONCLUSIONS: We established machine learning-based prediction models to predict POD in patients undergoing cardiac valve surgery. The random forest model has the best predictive performance in prediction and can help improve the prognosis of patients with POD.
PROBLEM TO BE SOLVED: To obtain the subject stable emulsified preparation with improved usability, namely, having nonsticky and refreshing feel when applied, by formulating a higher alcohol, a lipophilic nonionic surfactant and a silicone oil. SOLUTION: This emulsified preparation is obtained by including (A) as the principal medicament, one or more kinds selected from urea, sodium salicylate and pyrrolidonecarboxylic acid, (B) a water-soluble polymer (pref. a carboxyvinyl polymer, its amount to be formulated being >=0.15 wt.%), (C) a higher alcohol (pref. cetanol), (D) a lipophilic nonionic surfactant (pref. glycerol monofatty acid ester), and (E) a silicone oil (pref. <=50 mPa/s in viscosity at normal temperatures); wherein, it is preferable that, after emulsification process, such a process as to agitate and cool a mixture component containing at least component A from a temperature of >=50 deg.C is involved.
Participants randomized to the Intensive Behavioural Counselling condition will receive in-person intensive (\~45 minutes) behavioural counselling in the clinic at screening and at weeks 2, 4, 8, and 12. Additionally, on non-clinic visit weeks participants will receive (1) one phone call each week from the clinic counsellor, and (2) two text messages each week providing encouragement and advice. \].
The invention enables smooth measurement when obtaining optical tomographic information that takes a living body as a measurement object. A specimen holder (64) used as a measurement object holder is formed by a material having optical properties in which near-infrared light and fluorescence propagate while scattering isotropically. Further, the specimen holder (64) is divisible into a block 66 and a block 68 in a plane including the axial center. Recessed portions 66A and 68A are formed in the blocks (66, 68) in conformity with the outer shape and size of a specimen. A specimen 18 is accommodated in a cavity portion formed by the recessed portions (66A, 68A) such that its epidermis is in close contact with. Thereby, the specimen holder (64) holds the specimen (18) in a state where the original shape of the specimen (18) and the organ positions in the specimen (18) are maintained while performing a measurement with respect to the specimen (18).
PROBLEM TO BE SOLVED: To obtain a sheet coated with perfumes, deodorants, deodorizers or the like which suit individual tastes. SOLUTION: At least one of perfumes, deodorants and deodorizers is printed to sheets made of fabric, paper or porous material with a printer, particularly with an ink-jetting printer in 3dots/mm×3dots/mm to 35dots/mm×35dots/mm. When coloring is needed, an ink containing a dye is used, while in the case that coloring is unnecessary, no colorant is used. By utilizing a personal computer communication, sheets coated with perfumes or the like can be immediately obtained in a remote place. Moreover, a plurality of perfumes may be mixed by a personal computer and also an exact formulation data can be obtained. Further, a figure is drawn with a personal computer and a perfume suited for the figure is printed thereby giving sheets having the smell suiting individual tastes by utilizing their visual sense.  For example, a drawing in a room of a hotel is given smells different everyday and the room is deodorized with a sheet coated with a deodorant.
SOCS are a family of negative inhibitors of the molecular cascades induced by cytokines, growth factors and hormones. At molecular level, SOCS proteins inhibit the kinase activity of specific sets of receptor-associated Janus Activated Kinases (JAKs), thereby suppressing the propagation of intracellular signals. Of the eight known members, SOCS1 and SOCS3 inhibit activity of JAKs mainly induced by cytokines and can play key roles in regulation of inflammatory and immune responses. SOCS1 and SOCS3 are the most well-characterized SOCS members in skin inflammatory diseases, where their inhibitory activity on cytokine activated JAKs and consequent anti-inflammatory action has been widely investigated in epidermal keratinocytes. Structurally, SOCS1 and SOCS3 share the presence of a N-terminal domain containing a kinase inhibitory region (KIR) motif able to act as a pseudo-substrate for JAK and to inhibit its activity. During the last decades, the design and employment of SOCS1 and SOCS3-derived peptides mimicking KIR domains in experimental models of dermatoses definitively established a strong anti-inflammatory and ameliorative impact of JAK inhibition on skin inflammatory responses. Herein, we discuss the importance of the findings collected in the past on SOCS1 and SOCS3 function in the inflammatory responses associated to skin immune-mediated diseases and malignancies, for the development of the JAK inhibitor drugs. Among them, different JAK inhibitors have been introduced in the clinical practice for treatment of atopic dermatitis and psoriasis, and others are being investigated for skin diseases like alopecia areata and vitiligo.
The present invention discloses a traditional Chinese medicine volatile oil self-microemulsion nanometer composition and a preparation method. The components and the weight percentage contents of the traditional Chinese medicine volatile oil self-microemulsion nanometer composition of the present invention are 0.2 to 40% of traditional Chinese medicine volatile oil, 0.4 to 80% of surface active agent, 0 to 40% of cosurfactant and 0 to 99.40% of water. The present invention combines a self-microemulsion nanometer technology and traditional Chinese medicine volatile oil, medicine can be emulsified into the size of nanometer by itself in bodies, such as oral soft capsules, oral liquid, etc.; or medicine can exist in the form of nanometer preparations outside bodies, such as a sterile solution form and is prepared into injections, suction solutions, etc. The prepared self-microemulsion nanometer composition lowers the stimulation and the toxin of medicine and improves the absorption speed rate and the mucosa penetration capability of medicine simultaneously. Thereby, the biological availability of medicine is improved, the therapeutic effect of medicine is strengthened, and the compliance of patients for medication is improved.
An apparatus is provided. A strip has first and second end sections, and a first surface and second surface. Two electrocardiographic electrodes are provided on the strip with one of the electrocardiographic electrodes provided on the first surface of the first end section of the strip and another of the electrocardiographic electrodes positioned on the first surface on the second end section of the strip. A flexible circuit is mounted to the second surface of the strip and includes a circuit trace electrically coupled to each of the electrocardiographic electrodes. A wireless transceiver is affixed on one of the first or second end sections, and a battery is positioned on one of the first or second end sections. A processor is positioned on one of the first or second end sections and is housed separate from the battery.
An ischemic stroke mimic is detected, or otherwise predicted, based on medical images acquired from a subject. Medical image data, which include medical images acquired from a head of the subject, are accessed with a computer system. A machine learning model (e.g., one or more deep convolutional neural networks) is trained on training data to estimate a probability of an acute intracranial abnormality being depicted in a medical image. Intracranial abnormality prediction data are generated by inputting the medical image data to the machine learning model. The intracranial abnormality prediction data include an intracranial abnormality probability score for each of the medical images in the medical image data. An ischemic stroke mimic classification for the medical image data is generated based on the intracranial abnormality prediction data, and may be displayed to a user with the computer system.
Calcipotriol solution (Daivonex® scalp solution, calcipotriol 50 ug/ml) was purchased from LEO Pharmaceutical Products, Ltd. (Ballerupt, Denmark) and also distributed into 5-ml eye drop bottles for this trial.Each subject was asked to apply one to two drops (0.05 ml per drop) of the solution twice daily onto the nail folds, plus the hyponychium, of affected nails. The maximum period of treatment was 24 weeks or until there was complete clearing of their nail psoriasis.
Citrus plants are grown in diverse regions of the world, from subtropical to semi-arid and humid tropical areas. Through mechanisms essential for their survival, they adapt to the environmental conditions to which they are subjected. Although there is vast literature on adaptation of citrus plants to individual stresses, plant responses to interaction among different types of stresses have not been clearly examined. Abiotic or biotic stresses, or a combination of these stresses, result in reorganization of plant energy resources for defense, whether it be for resistance, tolerance, or prevention of stress. Plants generally respond to these stress factors through production of secondary metabolites, such as volatile compounds, derived from different biosynthesis and degradation pathways, which are released through distinct routes. Volatile compounds vary among plant species, meeting the specific needs of the plant. Simultaneous exposure to the stress factors of water deficit and herbivory leads to responses such as qualitative and quantitative changes in the emission of secondary metabolites, and compounds may accumulate within the leaves or predispose the plant to more quickly respond to the stress brought about by the herbivore. The genetic makeup of citrus plants can contribute to a better response to stress factors; however, studies on the emission of volatile compounds in different citrus genotypes under simultaneous stresses are limited. This review examines the effects of abiotic stress due to water deficit and biotic stress due to herbivory by Diaphorina citri in citrus plants and examines their connection with volatile compounds. A summary is made of advances in knowledge regarding the performance of volatile compounds in plant defense against both stress factors, as well as the interaction between them and possible findings in citrus plants. In addition, throughout this review, we focus on how genetic variation of the citrus species is correlated with production of volatile compounds to improve stress tolerance.