anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain an antiinflammatory agent excellent in effectiveness and safety. SOLUTION: This antiinflammatory agent contains a tranexamic acid amide compound of the formula (R1 , R2 are each H, a 1-18C alkyl, a 5-8C cycloalkyl, benzyl, phenyl, wherein the phenyl group and the phenyl part of the benzyl group may be substituted by one to three of lower alkyl groups, lower alkoxy groups, OH groups, amino groups or halogen groups) and its salt. The compound of the formula is e.g. N-methyl-trans-4-aminomethylcyclohexane carboxylic acid amide hydrochloride. The compound of the formula is obtained by protecting the amino group of tranexamic acid with a proper protecting group, reacting the product with an amine compound to produce the amide of the acid-protecting compound, and subsequently removing the protecting group from the amide.  The compound is administered at a dose of 1-200mg in one to three portions a day for an adult as an oral administration agent, injected at a daily dose of 0.01-10mg as a parenteral administration agent, or applied to a diseased part at a dose of 1-500mg once to several times a day as a coating agent or a suppository.
The invention discloses a tamariskoid spikemoss herb effective part for reducing blood lipid, and an extraction method and application thereof. The effective part is an ethyl acetate part obtained by extracting tamariskoid spikemoss herb by acetone water, concentrating and extracting by ethyl acetate. The tamariskoid spikemoss herb effective part for reducing blood lipid is obtained by extracting from lipid solubility part of tamariskoid spikemoss herb and the tamariskoid spikemoss herb is distributed widely in nature, so that the raw material is easy to obtain and low in cost. In addition, the extraction method has simple technological process and easy operation. Experiment shows that the amentoflavone obtained by further extracting the tamariskoid spikemoss herb effective part for reducing blood lipid has good function of reducing blood lipid. Experiment in vivo shows that the blood lipid level can be reduced by reducing serum total cholesterol and low-density lipoprotein cholesterol of hyperlipidemic mouse. The amentoflavone has higher extraction rate, and the once extraction rate can reach as high as 30 to 40 percent.
The invention belongs to the field of medicines, relates to application of andrographolide, and particularly relates to application of triacetyl andrographolide as a medicine for regulating degradation of autophagosomes. Application of triacetyl andrographolide in preparing medicine for promoting autophagosome elimination is provided. Its use as a medicament for simultaneously reducing the expression levels of LC3-II and P62 in the brain. Also can be used as a medicine for reducing phosphorylation levels of Akt and mTOR, improving learning and improving memory. The invention utilizes APP/PS1/Tau triple transgenic model mice and ApoE4 transgenic mice to prove that triacetyl andrographolide can effectively improve the learning and memory ability of model animals and reduce A beta in brains of the model animals 1‑40 And Abeta 1‑42 The level of (c). The triacetyl andrographolide can inhibit the activation of Akt-mTOR signals, relieve the excessive accumulation of LC3-II and P62 and reduce the aggregation of autophagosomes in vivo and in vitro models.
The gluteus medius muscle is part of a muscle group called the hip abductor muscles. The gluteus medius originates at the dorsal ilium (uppermost, largest bone of the pelvis) below the iliac crest and inserts at the top outside surfaces of the greater trochanter (top of the thigh bone). It is the major abductor of the thigh (moves the leg away from the midline of the body). The anterior fibres rotate the hip internally and the posterior fibres rotate the hip externally. Based on the anatomy and function of this muscle, the gluteus medius plays a major role in the mechanics of running. Research has shown that runners with iliotibial band syndrome have been shown to have weakness in this muscle. Most conventional exercises that have been research have been exercises that focus on only activation of this muscle in an unloaded position (non-weightbearing). Group B of this study will focus on those exercises that have been researched. Group C will be the experimental group in which we will begin with the conventional exercises and progress the exercises from a floor (unloaded) position to a more dynamic functional position (standing). This will be geared towards running specific exercises. We would like to know if there will be a difference in how fast symptoms reduce and strength gains occur and at what rate.
Individualized holmium-166 radioembolization will be performed via a catheter during angiography. Dosimetry-based treatment planning will be individualized based on Q-Suite™ software.
Provided is a biomarker capable of specifically diagnosing acute kidney injury. An acute kidney injury-specific biomarker is a miRNA that is primarily present in the blood. The miRNA is miRNA-5100. Furthermore, miRNA-5100 can be used as a method for diagnosing acute kidney injury. In this diagnosis, when the expression of miRNA-5100 is decreased in the blood, it is diagnosed as acute kidney injury. As an acute kidney injury test kit, it is also possible to include a reagent for measuring miRNA-5100.
PURPOSE: To present a new protocol using antibiotic irrigation during lithotripsy in retrograde intrarenal surgery (RIRS) to provide sterility of the renal collecting system.
METHODS: This prospective study included 102 patients who underwent RIRS between January 2022 and August 2023. The patients were examined in two groups as those who received antibiotic irrigation (n:51) and standard irrigation (n:51). In the antibiotic irrigation group, 80 mg of gentamicin was dissolved in normal saline in a 3 L irrigation pouch to obtain a 26.7 mg/L concentration. In the standard irrigation group, normal saline was used. Preoperative information, including age, sex, body mass index (BMI), ASA score, stone side, volume, and density, and the Seoul National University Renal Stone Complexity (S-ReSC) score. The groups were compared with respect to postoperative fever (> 38 °C), urinary tract infection (UTI), systemic inflammatory response syndrome (SIRS), infectious complications such as sepsis, and stone-free rate.
RESULTS: No statistically significant difference was determined between the groups with respect to age, sex, BMI, ASA score, stone side, volume and density, and S-ReSC score (p > 0.05 for all). Statistically significant differences were determined between the groups with respect to postoperative fever (p = 0.05), SIRS (p = 0.05), and hospital length of stay (p = 0.05). Sepsis was observed in one patient in the standard irrigation group and in none of the antibiotic irrigation group.
CONCLUSION: The reliability, efficacy, and utility of antibiotic irrigation during lithotripsy in RIRS were presented in this study as a new protocol for sterilization of the renal collecting system which will be able to reduce infectious complications.
PURPOSE: A composition for preventing alopecia and promoting hair growth is provided to supply nutrition to hair and to protect scalp. CONSTITUTION: A composition for preventing alopecia and promoting hair growth contains Acorus calamus var. angustatus root extract, Panax ginseng extract, Urtica laetevirens Maxim. extract, Cynanchum silfordii Hemsley extract, Sophorae flavescens Ait. extract, Swertia japonica Makino extract, Centella asiatica extract, Zanhosylum piperitum DC. extract, Portulaca oleracea extract, and Poria cocos extract. The composition is manufactured in the form of a shampoo, hair rinse, hair tonic, hair gel, hair lotion, hair spray, hair treatment, or hair dyeing agent.
Satisfactory reduction of some displaced pediatric supracondylar humerus fractures is not achievable via closed reduction, thus necessitating open procedure, which increases the incidence of complications. Using percutaneous prying-up technique to assist closed reduction may reduce the requirement for transform to an open operation. We retrospectively reviewed displaced pediatric supracondylar humerus fractures treated by the same surgeon from September 2021 to January 2024,with 134 subjects meeting criteria for inclusion. These children were divided into two groups. In Group A(n = 61),the prying-up technique was used to assist with closed reduction of fractures. Group B(n = 73) included fractures treated with conventional manual traction. To balance group size,12 fractures from group A were randomly removed, leaving a final 61 patients in each group. Demographics, operative time, the rate of failed closed reduction, complications and radiographic results were analyzed. The operative time was significantly less in Group A as compared with Group B(mean difference, - 7.22; [95% confidence interval (CI), - 8.49 to - 5.94]; p < 0.001). The rate of failed closed reduction were significantly lower in Group A as compared to Group B(2 of 61 vs. 10 of 61, p = 0.015).However, we found no difference in terms of the radiographic results and complications between the two groups(p > 0.05). percutaneous prying-up technique significantly improves the efficiency of surgery and reduces rate of failed closed reduction of supracondylar humeral fractures in pediatric patients. Level III, retrospective comparative study.See Guidelines for Authors for a complete description of levels of evidence.
<P>PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating and preventing cancer containing crude medicine components having little adverse effects even when administered for a long period of time or in a large amount with suppressing solely proliferation of cancer cells without affecting normal cells, and a composition which is a health-functional food for improving and preventing cancer containing the same as an effective component, easily taken as a health-functional beverage and easily carried with and ingested.  <P>SOLUTION: The composition contains Rhodiola sacra, Oldenlandia diffusa and Cistanche salsa (C.A. Meyer) G. Beck, wherein Rhodiola sacra is included in 10-70 pts.wt. based on 100 pts.wt. of the total composition and Oldenlandia diffusa is included in 20-80 pts.wt. based on 100 pts.wt. of the total composition.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Chronic kidney disease (CKD) and depression often coexist, resulting in a complex interaction that can be detrimental to patient outcomes. This article examines the reciprocal association between CKD and depression, with a focus on the increased incidence of depression and the harmful effects of depressive symptoms among patients with CKD. Next, it investigates the role CKD plays as a risk factor for the onset and worsening of depression because symptoms of depression may interfere with the progression of CKD. In addition, it highlights the difficulties in making a suitable diagnosis between CKD progression and depression regarding overlapping symptoms. Finally, it emphasizes the impact of depression on CKD outcomes, and proposes routine screening and non-pharmacological and pharmaceutical therapies to ease this dual burden. It is critical to identify and treat depression in the context of CKD to maximize patient outcomes and promote a comprehensive treatment approach.
Peer educator students group (a group of six senior nursing students), provided Newborn Physical Assessment training to 4th-year students in the nursing laboratory every week. Each training was conducted with a group of 5 students. This each training consisted of 30 minutes of theoretical presentation using a PowerPoint presentation material and 20 minutes of skills application on a newborn model, totaling 50 minutes. Before the training, the NPA-KT was administered, and the students' skills were evaluated using the NPA-SCL. At the end of the training, the NPA-KT and the Peer Support Scale were administered to the students. Three weeks after the training, the students' knowledge levels were re-evaluated using the NPA-KT.
The participant is randomly assigned to this group completes The Power as Knowing Participation in Change (PKPCT) to determine: 1. Freedom to Act Intentionally; 2. Involvement in creating change; 3.Freedom to act intestinally and 4. My involvement in creating change. The study measures are completed upon entry and 21 days post entry into the study and include: PKPCT and the SF-36v2.
More than 80% of stroke survivors have impaired walking ability, but most regain their ability to walk. While 40% of them need help while walking, 60% of the group do not have the ability to move independently outside the home. Balance disorder is the most common problem after stroke. Decreased muscle strength and joint range of motion and impaired coordination and sensory organization mechanism prevent balance. 80% of individuals who have had a stroke for the first time have balance disorder in the subacute phase. As a result of restricted balance, postural control deteriorates, the risk of falling increases and mobility decreases.

Interventions to improve gait function should be intense, repetitive, and task-oriented. Intensive efforts of more than one physiotherapist are required in patients who do not have independent gait. Robot assisted walking devices; provides high-intensity, repetitive, task-specific therapy. It both reduces the workload of physiotherapists and improves gait quality, functional results (walking speed and capacity) and motor performance with multi-sensory stimulation.
Subjects were treated with the dose of AMG 479 (12 mg/kg) in combination with gemcitabine. Gemcitabine (1000 mg/m2) was administered by intravenous infusion on days 1, 8 and 15 of each 28 day cycle followed by the AMG 479 infusion on days 1 and 15 after completion of the gemcitabine infusion.
INTRODUCTION: Brain dysfunction in sepsis is known as Sepsis-associated encephalopathy (SAE), which often results in severe cognitive and neurological sequelae and increases the risk of death. Neuron specific enolase (NSE) may serve as an important neurocritical biomarker for detection and longitudinal monitoring in SAE patients. Our Meta-analysis aimed to explore the diagnostic and prognostic value of serum NSE in SAE patients. Currently, no systematic Review and Meta-analysis have been assessed that NSE as a biomarker of SAE.
METHODS: The study protocol was registered in the PROSPERO database (CRD42023398736) and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We conducted a systematic review and Meta-analysis to evaluate the serum NSE's diagnostic accuracy for SAE and prognostic strength for probability of death of septic patients. We systematic searched electronic bibliographic databases from PubMed, MEDLINE, Web of Science, Embase, Cochrane databases, CNKI, CQVIP, and WFSD. QUADAS-2 assessment tool was used to evaluate quality and risk of bias of the selected studies. Subgroup analyses, funnel plots, sensitivity analyses were also carried out. Review Manager version 5.4 and Stata16.0. was used for statistical analysis.
RESULTS: This Meta-analysis included 22 studies with 1361 serum samples from SAE patients and 1580 serum samples from no-encephalopathy septic (NE) patients. The Meta-analysis showed that individuals with SAE had higher serum NSE level than NE controls (SMD 1.93 (95 % CI 1.51-2.35), P < 0.00001). In addition, there are 948 serum samples from survival septic patients and 446 serum samples from non-survival septic patients, septic patients with survival outcomes had lower serum NSE levels than those with death outcomes (SMD -1.87 (95 % CI -2.43 to -1.32), P < 0.00001).
CONCLUSION: Our Meta-analysis reveals a significant association between elevated NSE concentrations and the increased likelihood of concomitant SAE and mortality during septic patients. This comprehensive analysis will equip ICU physicians with up-to-date insights to accurately identify patients at risk of SAE and implement appropriate intervention strategies to mitigate morbidity and improve neurological outcomes. However, it is important to note that the presence of substantial heterogeneity among studies poses challenges in determining the most effective discrimination cutoff values and optimal sampling collection time.
The present invention discloses a wine for invigorating the kidney and preserving health. The wine is prepared by using spirit as a solvent and adding the raw materials of male chicken testicle, black bean, Chinese chive, anax parthenope, rice oil, black glutinous rice, barbary wolfberry fruit, Chinese yam, mulberry fruit, gordon euryale seed, lotus seed, powder of deer's blood, ginger, lotus leaf and Chinese date for soaking according to weight proportion. The wine abandons the existing prejudice by blindly using rare nourishing traditional Chinese medicines to prepare a tonic wine. The raw materials with wide source, low cost and excellent nourishing effect are carefully selected to prepare the wine by scientific and reasonable compatibility. Thus, the wine for invigorating the kidney and preserving health of the present invention has the characteristic of low cost simultaneously while ensuring the drinking effect. The wine for invigorating the kidney and preserving health has the advantages of benefiting vital energy, invigorating the kidney, strengthening and building the body, preserving health and prolonging life by long-term drinking. The wine can also be used for the adjuvant therapy of the diseases of sexual function subsidence, impotence, prospermia, alopecia, body ache and numbness caused by wind, cold and damp, etc.
Chronic varicella zoster virus (VZV) infection induced neuroinflammatory condition is the critical pathology of post-herpetic neuralgia (PHN). The immune escape mechanism of VZV remains elusive. As to mice have no VZV infection receptor, herpes simplex virus type 1 (HSV-1) infection is a well established PHN mice model. Transcriptional expression analysis identified that the protein arginine methyltransferases 6 (Prmt6) was upregulated upon HSV-1 infection, which was further confirmed by immunofluorescence staining in spinal dorsal horn. Prmt6 deficiency decreased HSV-1-induced neuroinflammation and PHN by enhancing antiviral innate immunity and decreasing HSV-1 load in vivo and in vitro. Overexpression of Prmt6 in microglia dampened antiviral innate immunity and increased HSV-1 load. Mechanistically, Prmt6 methylated and inactivated STING, resulting in reduced phosphorylation of TANK binding kinase-1 (TBK1) and interferon regulatory factor 3 (IRF3), diminished production of type I interferon (IFN-I) and antiviral innate immunity. Furthermore, intrathecal or intraperitoneal administration of the Prmt6 inhibitor EPZ020411 decreased HSV-1-induced neuroinflammation and PHN by enhancing antiviral innate immunity and decreasing HSV-1 load. Our findings revealed that HSV-1 escapes antiviral innate immunity and results in PHN by upregulating Prmt6 expression and inhibiting the cGAS-STING pathway, providing novel insights and a potential therapeutic target for PHN.
This is the control group. This group will be taking 0.02 grams of the "three-seeds" mixture once a day for three weeks.
Disclosed is an anticoagulant polypeptide and applications thereof. The anticoagulant polypeptide comprises a polypeptide formed by an amino acid sequence as represented in Seq. ID No. 1; or comprises a derived polypeptide that selectively inhibits coagulation factor Xla and is formed by an amino acid sequence, as represented in Seq. ID No. 1, that has undergone one or multiple amino acid residue substitutions, deletions, or insertions. The anticoagulant polypeptide is a selective inhibitor for coagulation factor Xla, has anticoagulant activity and small side-effect, and can be used in preparing medicines for the prevention and treatment of thrombotic diseases.
Patients received 15-ml mixture of bupivacaine 0.25% and 50 mcg fentanyl over 5 minutes , injected in the epidural space by epidural catheter at L3-L4 interspace, a dural puncture was created by the spinal needle. Braun's Espocan® combined spinal epidural kit before insertion of epidural catheter (needle-through-needle technique) but intrathecal medication administration was withheld.
This is a prospective study of montelukast efficacy in addition to standard treatment of status asthmaticus in children from 2-5 years old who are in the PICU. Children who meet eligibility requirements will be randomized to receive a rapid-dissolving oral dose of montelukast or placebo. Once enrolled, a baseline modified Wood's-Downes clinical asthma severity score will be recorded pre and post completion of a standard nebulized albuterol treatment of 0.15 mg/kg/dose (min2.5mg/dose). Patients who are able will have FEV1 measurements obtained at predetermined intervals for determination of clinical asthma severity score. Blood samples for PK analysis will be collected prior to study drug administration and at predetermined time intervals to determine the plasma level of montelukast. In addition, a blood sample will be obtained for genetic study of polymorphisms of CYP3A4, CYP3A5, and CYP2C9.
<P>PROBLEM TO BE SOLVED: To obtain a new protein having platelet aggregation-inhibiting activity.  <P>SOLUTION: Ti-4 Protein is the new protein derived from Triatoma infestans. Ti-4 Gene encoding the protein is obtained. Since the Ti-4 protein has platelet aggregation-inhibiting activity, the medicine containing the Ti-4 protein as an active ingredient is effective for treating and preventing cardiac infarction, pulmonary infarction and cerebral infarction as a platelet aggregation inhibitor. The Ti-4 protein has high possibility as a leading compound for a platelet aggregation inhibitor in the field of a medicine development.  <P>COPYRIGHT: (C)2004,JPO
There is a lack of knowledge regarding methotrexate (MTX) usage in patients with rheumatoid arthritis (RA) and its possible links with gender, disease characterization and sexual functioning, loneliness, fatigue and depression. We, therefore, investigated the associations of gender with physical function, fatigue, depression, loneliness and sexual functioning with a particular focus on MTX usage. A cross-sectional study design was used. Inclusion criteria were RA diagnosis, age above 18 years and available data on MTX treatment 1 year after diagnosis. Data consisted of responses from validated questionnaires regarding physical function, fatigue, depression, loneliness and sexual functioning combined with evaluations from medical records. Data were analysed with linear regression models comparing numerical outcome measures between male and female patients and between MTX users and MTX non-users. Amongst 286 patients with RA (69 men and 217 women), 67.8% were MTX users 1 year after diagnosis. Comparing women and men, both overall and within subgroups of MTX usage, we found significantly more adverse outcomes for women than men in physical functioning at diagnosis and in sexual function, depression, fatigue and physical functioning at enrolment in the study. Gender differences were also present when comparing MTX users with MTX non-users divided by gender. There were only significant differences in the HAQ and loneliness scores when comparing MTX users with MTX non-users. Women with RA had more negative outcomes measured by the selected PROMs compared to men with RA, both overall and in subgroups of users and non-users of MTX. These findings call for sharpened attention to the importance of gender in the treatment and care of patients with RA, as well as in future clinical research.