anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Anesthesia maintenance: After endotracheal intubation, patients will be randomized into Desﬂurane for maintenance. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.
Ischemia reperfusion (I/R) was considered as one of main causes of acute kidney injury (AKI). However, the exact mechanism remains unclear. Here, this study aimed to investigate the role and mechanism of the m6A demethylase fat mass and obesity-associated (FTO) protein in I/R-induced AKI. HK-2 cells and SD rats were utilized to establish hypoxia/reoxygenation (H/R) or I/R induced AKI models. The changes of RNAs and proteins were quantified using RT-qPCR, western blot, and immunofluorescence assays, respectively. Cell proliferation and apoptosis were assessed by CCK-8 and flow cytometry. Interactions between molecules were investigated using RIP, ChIP, Co-IP, RNA pull-down, and dual luciferase reporter assays. Global m6A quantification was evaluated by kits. TUNEL and HE staining were employed for histopathological examinations. Oxidative stress-related indicators and renal function were determined using ELISA assays. The FTO expression was downregulated in H/R-induced HK-2 cells and renal tissues from I/R-induced rats. Overexpression of FTO improved the cell viability but repressed apoptosis and oxidative stress in H/R-treated HK-2 cells, as well as enhanced renal function and alleviated kidney injury in I/R rats. Notably, the FTO overexpression significantly increased autophagy-related LC3 and ULK1 levels. When autophagy was inhibited, the protective effects of FTO in AKI were diminished. Notably, Ambra1, a crucial regulator of autophagy, was repressed in H/R-induced HK-2 cells. However, the FTO overexpression restored the Ambra1 expression by reducing m6A modification of its mRNA. SP1, acting as an upstream transcription factor, directly interacts with the FTO promoter to enhance FTO expression. Knockdown of SP1 or Ambra1 suppressed the beneficial effects of FTO upregulation on autophagy and oxidative stress injury in H/R-stimulated cells. FTO, transcriptionally activated by SP1, promoted autophagy by upregulating Ambra1/ULK1 signaling, thereby inhibiting oxidative stress and kidney injury. These findings may provide some novel insights for AKI treatment.
In Period 1: Bupropion, Caffeine, Midazolam are given as a reference treatment. In Period 2: Survodutide, Bupropion, Caffeine, Midazolam are given as a test treatment.
The invention relates to the technical field of biomedicine, in particular to a structure of a serine protease inhibitor-3 (Serpin-3), an obtaining method thereof, a new physiological function and application thereof in the field of biomedicine. The amino acid and nucleotide sequence of the whole sequence of Serpin-3 are shown as SEQ ID NO:1 is shown. The amino acid and nucleotide sequences of the Serpin-3 mature peptide are shown in SEQ ID NO:2, respectively. The invention also provides an analogue or an active fragment of the recombinant Serpin-3. The natural and recombinant Serpin-3 and the analogues and partial fragments thereof have the inhibition effects on serine protease, antibacterial peptide synthesis and activation of a prophenoloxidase activating system in vivo and in vitro. The natural and recombinant Serpin-3 and the partial fragments or the analogues thereof have the advantages of conventional and simple method and high yield.
This study is aimed at showing the effectiveness and safety of electroacupuncture therapy for the stroke survivors with shoulder pain. 60 stroke survivors with shoulder pain will be enrolled in two traditional Korean medicine hospitals and randomly divided into either of verum or sham electroacupuncture group with 1:1 of allocation ratio. The participants will receive 9 sessions of electroacupuncture procedures for 3 weeks. Patients and outcome assessors will be blinded from the beginning to the study completion. Visual analogue scale will be primarily evaluated, and pain rating scale, Fugl-Meyer assessment upper extremity, modified Ashworth scale, manual muscle test, passive range of motion, Korean version of modified Barthel index, and Korean version of Beck depression inventory will be measured, too. Blinding index will be assessed. For safety, adverse events will be collected.
This is a prospective, randomized, controlled, multi-center study in which up to 300 evaluable subjects will receive MiniStim PNS. Target subjects will have chronic knee pain.

Subjects will be randomized into either the active or delayed group. Devices will be activated post-op in accordance to the randomization assignment. Subjects randomized to the Active group, programming parameters will be set, and therapy will be delivered for a minimum of 2-hours per day for the duration of the study. Implanted subjects will be educated on the use of the transmitter. Programming changes can be done as needed during this time period to maximize clinical response according to pre-programmed settings. Subjects randomized to the Delayed group will begin 2-hour stimulation/day at the 3-Month visit.

The primary endpoint will be at 3-Months, comparing Active vs. Delayed data from baseline data, and subjects in the Delay group will begin stimulation. At the 3-month visit, VAS will be completed and compared to baseline VAS, during this visit the safety and efficacy of the device will be assessed, and subjects in the Delayed group will be instructed to begin daily stimulation for a minimum of 2 hours a day. Subjects will be seen at 3-month intervals through the 12-Month visit for data collection and adverse event review. Subjects will continue therapy and followed for a total of 36-months with primary outcomes assessed at 3-months. Their participation in the study will end at 36-months.
Indomethacin Capsules, USP for oral administration are provided in two dosage strengths which contain either 25 mg or 50 mg of indomethacin. Indomethacin is a non-steroidal anti-inflammatory indole derivative designated chemically as 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid.

The structural formula is:

C19H16ClNO4 M.W. 357.79 

Indomethacin, USP is practically insoluble in water and sparingly soluble in alcohol. It has a pKa of 4.5 and is stable in neutral or slightly acidic media and decomposes in strong alkali.

Each capsule for oral administration contains 25 mg or 50 mg of indomethacin and the following inactive ingredients: lactose monohydrate, sodium lauryl sulphate, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate. The hard gelatin shell consists of gelatin, titanium dioxide USP, FD & C Blue 1, D & C Yellow 10. The capsules are printed with black ink containing black iron oxide E172 dye.
Professional CGM calibrate blood glucose via a glucsoe-oxidase-impregnated membrane during a 5 day period. The patient wearing professional CGM is randomized to immediate feedback after data downloaded into computer.
AIM: The objective was to evaluate the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1α), and apelin 13 in patients with acute pulmonary thromboembolism (PE) and to investigate their diagnostic and prognostic role in PE patients with different mortality risk groups.
MATERIAL AND METHODS: This study was conducted in a tertiary referral center and included 124 subjects with 94 cases of PE and 30 cases of healthy control group. All subjects were 18 years of age or older. The diagnosis of PE was done with computed tomography angiography of the thorax. After the diagnosis of acute PE, the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1α), and apelin 13 levels were measured with a commercial enzyme-linked immunosorbent assay (ELISA) kit.
RESULTS: The median and IQR (interquartile range) age of patients and control groups were 68 (56-76) and 61.5 (56-67) years, respectively. The majority of patients with PE had risk factors (97.88 %), and only two (2.12 %) had no known risk factors. HIF-1 alpha level was found to be higher in the patient group than in the control group (p = 0.03). At the same time, the HIF-1 alpha level was found to be higher in the high mortality risk group than in the control group, low mortality risk group and intermediate-low mortality risk group (p = 0.000, 0.011, 0.002, respectively). While there was no significant difference in NGAL level between the patient group and the control group, a significant difference was observed between the mortality groups. NGAL level was found to be higher in the high mortality risk group than the control group, low mortality risk group, and medium-low mortality risk group (p = 0.001, 0.000, 0.010, respectively). Apelin 13 levels did not differ significantly in all groups.
CONCLUSION: HIF-1 alpha is a promising biomarker in distinguishing between patients and control groups and in identifying those with high mortality risk in the patient group. At the same time, NGAL can be used as a successful biomarker in determining the group with high mortality risk in cases of PE.
A licensed, independent therapist and caregivers will provide the training program in the public space in the university for 2 hours/per session, 2 sessions/per week for a total of 12-week intervention based on ecological and dynamic systems theories. Each week the participant will wear a light-weight, head-mounted eye-tracker for recording the first 10-minute of driving and natural play sessions in a 2-hour training session. The 2-hour training session is composed of a 70-minute driving session and a 50-minute natural play session. Training will concentrate on building the concept of casual-effect on the control system and car motion, practicing goal-oriented driving in certain public spaces, upper limb use in functional tasks for exploration in driving sessions, and applying various motor skills for mobility and socialization in natural play sessions. The program will be discussed by the family and the treating therapist.
The invention relates to food industry, in particular to the method of processing the vegetable raw material, and it can be used for preparing the vitamin-containing organometallic plant complex with retention of biologically active materials of the natural raw material, which has a wide range of application for any form of biological objects (man, animals, birds, insects, plants etc). Processing vegetable raw material is carried out by mummification thereof, during which extraction of the vegetable raw material is carried out by vapor-liquid working under the temperature of 105-200 °C and pressure up to 0.5-10 atm with addition to the vegetable raw material of a prepared extractant in mass ratio 3-13: 1. Specially prepared drinking water is used as the extractant, which contains microcells in the form of salts of metals allowable from the point of view of the standards of drinking water, which surely include, besides other, salt of nickel, cobalt and iron, or prepared water-alcohol solution on the base of specially prepared drinking water with a water-soluble organic solvent in the concentration of 5-50 %, mainly with alcohol or mixture of alcohols from the group allowable in the food industry. The produced extract is mixed up with dry similar to initial or another vegetable raw material in the ratio 1:0.3 - 1: 10 mass per cent. Then final drying and crushing up to powdery state is performed with producing the mummified end product - vitamin-containing organometallic plant complex. The invention ensures decrease of duration of the entire technological process and power consumption, reduction of the cost of end product and improvement of its quality due to mummification of the raw material and producing the enriched end product with properties of natural product, and also extension of used raw-material base.
FIELD: medicine; biochemical engineering. SUBSTANCE: method involves crushing, suspending, raw material in 2-3 water volumes at 10.-10.5 pH and centrifuging it. Non-ionic detergent ingredient, mainly Neonol, is added to liquid above the precipitate to reach resulting concentration of 0.8-1.5%. The mixture is hold at 20-25 C during 14 h or longer. Uricase is precipitated with ammonium sulfate taken at the final concentration of 9.5-11%, the so produced precipitate is dissolved in 1% sodium carbonate solution and the end product is repeatedly precipitated with ammonium sulfate taken at the same concentration. EFFECT: simplified production process; high degree of purity. 3 cl
Intratympanic injection of methylprednisolone (methylprednisolone succinic acid for injection) at a dose of 40mg/mL, once every two days, three times in total. 40mg of methylprednisolone was dissolved in 0.2 ml of lidocaine injection and 0.8 ml of sterilized injection water.
Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
Limited information on nitazoxanide overdosage is available. Single oral doses of up to 4000 mg nitazoxanide have been administered to healthy adult volunteers without significant adverse effects. In the event of overdose, gastric lavage may be appropriate soon after oral administration. Patients should be observed and given symptomatic and supportive treatment. There is no specific antidote for overdose with ALINIA. Because tizoxanide is highly protein bound (>99.9%), dialysis is unlikely to significantly reduce plasma concentrations of the drug.
Beginning at weeks 4 and 5 or 5 and 6 of radiotherapy, patients undergo neurofeedback training QID TIW for up to 6 treatments. Patients also complete questionnaires over 10 minutes at baseline and after neurofeedback training.
Patients receive imatinib mesylate PO QD. Treatment repeats every 4 weeks for up to 5 years in the absence of disease progression or unacceptable toxicity.
The present disclosure relates to blood treatment systems, units, modules, apparatuses, and methods useful for blood circulation, hemodialysis, hemofiltration, hemodiafiltration, apheresis, and the like. Modular systems (1910) are provided that include a first base module (1920) comprising a dock (1828), and a first portable module (1520) configured to dock the first base module (1920) and configured to operate independently of the first base module (1920) in an undocked configuration. The first base module (1920) comprises a base module housing (1922) and a primary dialysate circuit. The first portable module (1520) comprises a first portable module housing (1522), a blood pump mounted in or on the first portable module housing (1522), a first extracorporeal blood circuit tubing set, and a second inter-module connector complementary to the first inter-module connector and configured to connect to the first inter-module connector in the docked configuration, wherein the blood pump is configured to releasably engage the extracorporeal blood circuit tubing set. Methods of using the modular systems are also provided, for example in the preparing for, and the conducting of, blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration. The systems and methods enable the engagement and disengagement of the portable module from the base module to conduct, interrupt, and resume blood treatments without disconnecting the extracorporeal blood circuit tubing set from the vasculature of a patient.
This is an open-label (all people know the identity of the intervention), non-randomized (the study drug is not assigned by chance) study to evaluate the efficacy and safety of paliperidone ER in adult Thai schizophrenia participants. The study consists of a screening phase and an open-label treatment phase. Study duration will be 10 weeks and participants can either be inpatient or outpatient. The recommended paliperidone ER starting and maintenance dose will be 6 milligram (mg) per day for most participants. Throughout the study, flexible dosing ranging from 3 to 12 mg per day may be used at the discretion of the investigator. Throughout the study, participants will be evaluated for efficacy using clinician rating (Clinical and Global Impressions-Severity \[CGI-S\] scale, and Personal and Social Performance Scale \[PSP\]) scales. Safety of the participants will be monitored.
The purpose of this study is to determine the role of respiratory viruses in the etiology of medically attended acute respiratory illness in elderly populations and to assess the impact of these illnesses. Ambulatory elders presenting for health care with an acute respiratory illness will be recruited. Nose and throat swab specimens will be collected to test for one of the respiratory viruses, and acute and convalescent blood specimens will be collected to test for increases in specific antibody. Specimens will be collected within seven days of the onset of illness and then 1 month later for comparison specimens. A brief questionnaire will accompany the specimens, and more complete data on the illness and consequences will be obtained from the medical record. The pattern of illnesses by virus and their severity and duration will be determined.
This arm tests use of video game to help preteens in the decision to pursue HPV vaccination. Participants in the intervention group are asked to play the Land of Secret Gardens game and complete 3 tasks: (1) play a shield game with blue spikey virus balls, (2) find hidden objects in 4 different garden sheds, and (3) create a potion (vaccine). Participants in the intervention arm are asked to respond to surveys about HPV and HPV vaccine knowledge, vaccination self-efficacy and decisional balance, the Physical/Emotional/Narrative Presence Scale (PENS) to gauge preteens' immersion in the game, and game play experience.
Fibrous dysplasia (FD) is a skeletal disorder characterized by the replacement of normal bone by fibrous tissue. Malignant transformation of FD is extremely rare and has been reported in both monostotic and polyostotic forms of FD. The most frequently reported malignant transformation is osteosarcoma. Among malignant bone tumors, spindle cell sarcomas are uncommon and difficult to diagnose. This report presents the case of a 30-year-old woman with an unusual presentation of a malignant undifferentiated spindle cell neoplasm secondary to fibrous dysplasia. The clinical features, radiological findings and management are discussed.
The system for monitoring and dispensing medical items which are dispensed for administration to patients includes a data terminal ( 76, 338 ) which is connected through a network ( 82, 328 ) to at least one remote computer ( 84, 324 ) having a processor and a data store. The system also includes a reading device ( 348 ) which is connected to the network. A user of the data terminal or the reading device is enabled to select a patient for whom medical items will be used, and responsive to a request to dispense items the requested items are dispensed from dispensing devices ( 96, 100, 344, 346, 450, 527 ) connected to the data terminal. A report generating device ( 384 ) generates reports ( 388 ) which include machine readable indicia corresponding to patients and/or medical items. Users may select patients and dispense medications by reading the indicia from the reports using the reading device. Certain storage locations are also labeled with machine readable indicia which may be read to indicate the taking of items therefrom as well as to indicate inventory status information. One such dispensing device in the system is a cabinet ( 550 ). The cabinet may be configured with various configurations of drawers or shelves by supporting connecting members in apertures which extend in the interior walls of the cabinet.
Regulatory guidance materials for fatigue management typically advise that employees be provided with days or weeks of advance notice of schedules/rosters. However, the scientific evidence underpinning this advice is unclear. A systematic search was performed on current peer reviewed literature addressing advance notice periods, which found three relevant studies. A subsequent search of grey literature to determine the quality of evidence for the recommendation for advance notice periods returned 37 relevant documents. This review found that fatigue management guidance materials frequently advocated advance notice for work shifts but did not provide empirical evidence to underpin the advice. Although it is logical to suggest that longer notice periods may result in increased opportunities for pre-work preparations, improved sleep, and reduced worker fatigue, the current guidance appears to be premised on this reasoning rather than empirical evidence. Paradoxically, it is possible that advance notice could be counterproductive, as too much may result in frequent alterations to the schedule, particularly where adjustments to start and end times of the work period are not uncommon (e.g., road transport, rail). To assist organisations in determining the appropriate amount of advance notice to provide, we propose a novel theoretical framework to conceptualise advance notice.
A process for making multi-phase liquid compositions is disclosed. For example, a plurality of liquid phases can be placed in separate vessels equipped with supply lines. Predetermined amounts of each of the liquid phase can be transferred, via the supply lines, into a combiner that aligns each of the liquid phases. The liquid phases can be transferred from the combiner to a blender. A mixing element of the blender can blend the liquid phases together to produce a multi-phase liquid composition having a visually distinct pattern formed by the liquid phases. The multi-phase liquid phase composition can be transferred to an individual product container via a delivery nozzle. When said multi-phase liquid composition is transferred to said individual product container via said delivery nozzle, the individual product container can be rotated, via a rotating platform of a bottle holding device.