anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses aliphatic polyester-b-poly(ethylene oxide-co-propylene epoxide) amphipathy block copolymers side hydrophilic chains of which are provided with different functional groups, and a preparing method of the copolymers. The functional groups comprise halogen, azido, amino, carboxyl, and other groups. P(EO-co-ECH) is synthesized under mild reaction conditions through a controllable anionic coordinate polymerization method. A random copolymer (P(EO-co-Glycidyl Azide)) side chains of which is provided with the azido is obtained by azidation of the halogen on the P(EO-co-ECH). An amphipathy block copolymer the side hydrophilic chains of which are functionalized is obtained by subjecting the P(EO-co-Glycidyl Azide) and an aliphatic ester monomer to ring opening polymerization. Through reduction and click chemistry reactions, the azido of the block copolymer is converted, so as to obtain a series of amphipathy block copolymers the side hydrophilic chains of which are provided with the different functional groups such as amino and carboxyl are obtained.
This invention is based on the discovery of the human galectin-4 gene, and the discovery that human galectin-4 is expressed in breast cancer. The invention provides an isolated polynucleotide encoding human galectin-4, and the human galectin-4 polypeptide. Antibodies which bind human galectin-4 polypeptide and formulations for administration of these antibodies are also disclosed. The present invention provides a method of diagnosing or determining the prognosis of cell proliferative disorder, such as breast cancer, associated with the human galectin-4. A method of determining the presence of metastases in a sample from a subject by determining the presence or absence of galectin-4 is also disclosed. A method of treating a subject having, or at risk of having, a human galectin-4 associated disorder, such as breast cancer, is also provided. A kit useful for detecting the presence of human galectin-4 polypeptide or polynucleotide in a sample from a subject having a human galectin-4-associated disorder is disclosed. A method of identifiying compounds which affect human galectin-4 expression is also provided. Transgenic nonhuman animals having a transgene encoding human galectin-4 are also described.
The present disclosure provides a coating composition including a pectin and a non-glycerol sugar alcohol. The pectin can be present in an amount by weight of at least 30.0% and at most 50.0%. The non-glycerol sugar alcohol can be present in an amount by weight of at least 10.0%) and at most 40.0%. The pectin can be present in a ratio of at least 1:1 and at most 5:1 relative to the non-glyercol sugar alcohol. The present disclosure also provides coating suspensions, coatings, and coated substrates related to the coating composition. The present disclosure also provides methods of making and using the coating compositions.
Hemorrhagic shock (HS) is a common complication after traumatic injury. Early identification of HS can reduce patients' risk of death. Currently, the identification of HS relies on macrocirculation indicators such as systolic blood pressure and heart rate, which are easily affected by the body's compensatory functions. Recently, the independence of the body's overall macrocirculation from microcirculation has been demonstrated, and microcirculation indicators have been widely used in the evaluation of HS. In this study, we reviewed the progress of research in the literature on the use of microcirculation metrics to monitor shock. We analyzed the strengths and weaknesses of each metric and found that microcirculation monitoring could not only indicate changes in tissue perfusion before changes in macrocirculation occurred but also correct tissue perfusion and cell oxygenation after the macrocirculation index returned to normal following fluid resuscitation, which is conducive to the early prediction and prognosis of HS. However, microcirculation monitoring is greatly affected by individual differences and environmental factors. Therefore, the current limitations of microcirculation assessments mean that they should be incorporated as part of an overall assessment of HS patients. Future research should explore how to better combine microcirculation and macrocirculation monitoring for the early identification and prognosis of HS patients.
The annual occurrence of gastrointestinal (GI) bleeding is approximately 150 per 100,000 in the US and accounts for 300,000 hospitalizations per year with a death rate of 5%. Qualitative assessments of blood tests monitoring patients with or are thought to have GI bleeding can lack accuracy and objectivity, delaying conformation of the bleed through endoscopy. Early endoscopies have been linked to more favorable outcomes for patients with heavier GI bleeding and earlier discharge times for patients with less severe GI bleeding. Additionally, laboratory values are not documented at regular intervals, which makes identifying when GI bleeding exactly occurred difficult. In this study, the investigators aim to improve methods of monitoring and diagnosing GI bleeding via the E4 wristband, a biosensor watch. Using data from the E4 wristband, the investigators will train a model to recognize GI bleeding through analyzing the heart rate and skin conductance of both patients with GI bleeding and who may have GI bleeding while they are not bleeding and while they are bleeding. Monitoring both types of patients while they are and are not bleeding will help the model discern which vital signs are critical. Additionally, the investigators will be using blood tests and other traditional methods of diagnosis to create a standard for vitals that characterize GI bleeding. If the E4 wristband is successfully able to accurately identify when a patient is experiencing GI bleeding, then speed of GI bleeding detection and the ability to monitor GI bleeding will dramatically increase, leading to quicker discharge times, reduced risk of rebleeding, and a lower death rate for afflicted patients.
After singing an informed consent, and prior to IOL initiation, study participants were randomly assigned (1:1) to receive either intermittent or continuous Oxytocin infusion. Both groups received the same primary infusion dose of Oxytocin 1.0 with an incremental increase of 2.5 every 30 minutes until 20, titered to a target of 3-5 contractions in a 10 minute period. During Oxytocin infusion, fetal heart rate was continuously monitored. Artificial ROM was performed according to the accepted indications, local protocol and by the staff physician discretion who was in charge on the labor ward at that time, regardless of oxytocin initiation time. In the intermittent Oxytocin infusion group, Oxytocin was discontinued after 8 h if the patient did not go into active labor during by that time, and renewed 4 h later. In the continuous infusion group, patients received a continuous Oxytocin infusion for 16 h. If they did not go into active labor within this frame time, Oxytocin was discontinued for 4 hours and then resumed. In addition, during Oxytocin infusion, sodium levels were monitored every 8 h.
Sevoflurane is considered an effective neuroprotector in cerebral ischemia/reperfusion injury (CIRI). Sevoflurane preconditioning in CIRI, however, remains unknown precisely by its molecular mechanism. The middle cerebral artery occlusion reperfusion (MCAO/R) rat model was established, and neurological function was evaluated by Zea-Longa score. Cerebral water content was determined to assess cerebral edema. Brain pathological condition was observed by hematoxylin and eosin staining, the intact changes of rat neurons were observed by Nissl staining, and neuronal apoptosis was measured by TUNEL staining. In addition, miR-192-5p and DICER1 levels were detected by RT-qPCR or Western blot, and the targeting relationship between miR-192-5p and DICER1 was verified by bioinformatics analysis and luciferase reporting experiment. miR-192-5p was up-regulated and DICER1 was down-regulated in MCAO/R rats. Sevoflurane preconditioning could decrease miR-192-5p and promote DICER1 expression. Sevoflurane preconditioning could alleviate brain tissue injury and neuronal apoptosis in MCAO/R rats. DICER1 expression was negatively regulated by targeting miR-192-5p. Elevating miR-192-5p or suppressing DICER1 rescued the protective effect of sevoflurane preconditioning on MCAO/R rats. Sevoflurane alleviates brain injury in MCAO/R rats via miR-192-5p/DICER1 axis.
Techniques disclosed herein relate to generating and applying subject event timelines for various purposes. In various embodiments, data indicative of a plurality of medical events associated with a subject may be retrieved ( 502 ) from data sources ( 102 - 110 ). For example, natural language processing may be performed ( 504 ) on a narrative data record to extract concept(s) associated with a first medical event. Each of the plurality of medical events may be associated ( 508 ) with a respective timestamp. Based on the plurality of medical events and associated timestamps, a timeline data structure associated with the subject may be assembled ( 510 ) and used to render a visual timeline ( 232 ) indicative of the plurality of medical events on a display. Each respective medical event of the plurality of medical events may be represented by a graphical element ( 234 ) that is operable to cause additional information ( 236 ) about the respective medical event to be output.
Patients will be randomized to receive standard radiographic/endoscopic surveillance plus placebo. Patients will continue placebo for 3 years during follow-up.
Polycystic ovary syndrome (PCOS) is a multifaceted and heterogeneous disorder, linked with notable reproductive, metabolic, and psychological outcomes. During adolescence, key components of PCOS treatment involve weight loss achieved through lifestyle and dietary interventions, subsequently pursued by pharmacological or surgical therapies. Nutritional interventions represent the first-line therapeutic approach in adolescents affected by PCOS, but different kinds of dietary protocols exist, so it is necessary to clarify the effectiveness and benefits of the most well-known nutritional approaches. We provided a comprehensive review of the current literature concerning PCOS definition, pathophysiology, and treatment options, highlighting nutritional strategies, particularly those related to high-fat diets. The high-fat nutritional protocols proposed in the literature, such as the ketogenic diet (KD), appear to provide benefits to patients with PCOS in terms of weight loss and control of metabolic parameters. Among the different types of KD studies, very low-calorie ketogenic diets (VLCKD), can be considered an effective dietary intervention for the short-term treatment of patients with PCOS. It rapidly leads to weight loss alongside improvements in body composition and metabolic profile. Even though extremely advantageous, long-term adherence to the KD is a limiting factor. Indeed, this dietary regimen could become unsustainable due to the important restrictions required for ketosis development. Thus, a combination of high-fat diets with more nutrient-rich nutritional regimens, such as the Mediterranean diet, can amplify positive effects for individuals with PCOS.
Background Pre-exposure prophylaxis (PrEP) use has been attributed to heightened rates of sexually transmitted infections (STIs), ostensibly due to increased condomless anal sex (CAS) and greater frequency of STI testing. Few qualitative studies have assessed how gay, bisexual and queer men (GBQM) who use PrEP perceive STIs and how these attitudes have evolved post-PrEP uptake. We investigated the perspectives of current and former PrEP users on STIs. Methods Annual, in-depth longitudinal interviews were conducted with 38 current and former PrEP users in Ontario (n =18) and British Columbia (n =20), Canada, as part of a mixed-methods implementation science study (2020-2022). Over 3years, 109 interviews were conducted. Data analysis included reflexive thematic coding and longitudinal recurrent cross-sectional analysis using NVivo 12. Results Four STI-related themes emerged: (1) lack of STI-related concerns due to treatment and prevention optimism, (2) stigma-related concerns, (3) perceived risk among other PrEP users due to increased CAS, and (4) inconsistent testing concerns among non-PrEP users. Over time, some STI-related anxieties decreased with increased knowledge and reduced stigma. However, concerns persisted for other participants due to perceived risky sexual behaviours among other PrEP users and non-PrEP users. Both current and former PrEP users who expressed STI-related apprehensions consistently indicated adopting risk-reduction strategies, including condom use and having fewer sexual partners throughout the study. Conclusions Findings show how varied STI perceptions and experiences among current and former PrEP users shaped sexual decision-making over time. Providers, public health experts, and policymakers should develop a more comprehensive strategy to address STI concerns among GBQM.
BACKGROUND: Although mesenchymal stem cells (MSCs) have been proven to be appropriate candidates for the treatment of AKI-CKD, their efficacy is limited and variable. Astilbin (AST) had a protective effect on MSCs from oxidative stress via ROS-scavenging, however, whether it can improve MSCs' renoprotection and the underlying mechanism need to be elucidated.
METHODS: AST-pretreated MSCs were administered intravenously into the ischemia-reperfusion injury mice models and the renal function, pathological changes and inflammation. Were evaluated. In addition, DARTS, molecular docking, surface plasma resonance(SPR), dual-luciferase reporter gene assay and the ChIP-PCR were utilized to explore the potential signaling pathways through which AST exert renal protective effects on MSCs.
RESULTS: AST-pretreated MSCs markedly improved kidney function, reduced kidney pathological injury and inflammation in AKI and AKI-CKD mice. RNA-seq results showed that PTGS2 related pathway was significantly up-regulated in MSCs after AST pretreatment. DARTS assay, molecular docking and SPR assay revealed that AST could bind with the transcriptional factor of Kruppel-Like Factor 4(KLF4) protein. The promoter of PTGS2 had the binding and transcriptional activation by KLF4. Furthermore, AST pretreatment promoted the secretion of PGE2 in MSCs. And then the westren blot results showed that the protein levels of CD163 and CD206 were upregulated after coculture in AST-pretreated MSCs, indicating that the polarization of RAW264.7 cells towards M2-like macrophages was induced. Knockdown of PTGS2 reversed the ability of AST-pretreated MSCs in converting macrophages to M2 phenotype and reducing their therapeutic effects on AKI-CKD mice.
CONCLUSION: AST pretreatment enhances the efficacy of MSCs on AKI and AKI-CKD mice by inducing of M2-like phenotype polarization in macrophages through the PTGS2-mediated pathway. This approach not only provides a novel strategy to strengthen the capability of MSCs but also helps elucidate the beneficial effects of the Chinese herbal medicine AST.
An interactive pill dispensing system, apparatus, and methods with advanced capabilities for medication management and adherence. In the broadest terms, the system comprises an advanced pill dispensing apparatus with one or more user-interfaces, computing, mobile communication, networking, and Artificial Intelligent (AI) digital assistant capabilities. These capabilities enable the pill dispensing user (patient) to be connected to a support system of care givers. The apparatus functions as an integral component of an ecosystem for medication management and adherence. The ecosystem comprises one or more said apparatus, local area network (LAN), wide area network (WAN), Internet of Things (IoTs), a cellular network, Internet, ISP, mobile cellular phone, local server, remote server, cloud server, cloud computing services, laptop, desktop computer, database, application software, smart appliances. One or more of said components are configured to enable seamless communication between patient, caregivers, healthcare providers, and service providers.
The study arm in which only radiotherapy is administered. RT Dose: 12 fractions of 4 Gy each, delivered 3 times per week, with sessions scheduled every other day (exceptions can be made in weeks with holidays) over four weeks.
Analysis of cell populations for both research and clinical applications such as cell therapy is often performed on whole blood that is close to 24 hours old. The reason for this is that the analysis site is removed from the blood draw site so that blood must be shipped overnight to the analysis site. During the 24-hour shipping period, granulocytes and other blood components break down into undesirable cell debris including nucleic acids that are released into the blood. Such debris is known to interfere with immunological assays and with thawing following freezing of samples. The present invention solves this issue by removing granulocytes (and optionally other components) using an anti-CD15 molecule (or other appropriate molecule) bound to metallic magnetic particles. Following mixing, the granulocytes (or other components) are removed and prepared for shipment to the analysis site or for other reasons.
The intervention is a cognitive behavioral therapy (CBT) based automated conversational agent available as a mobile device smartphone application. When a user logs in with the app, it asks questions about that user, such as how they're feeling, and the user is able to type their response, similar to texting or messaging. The app is then available for use by the user anytime (24 hours per day 7 days per week), and will check in with the user to encourage mood tracking followed by tailored delivery of CBT-based tools and other general psychoeducation. This smartphone app interacts with conversational tones, and offers empathy and behavioral pattern insight to users. The app's artificial intelligence becomes more specific to a user over time, based on conversations. The app allows patients are able to immediately process and receive empathy for significant events and removes barriers traditionally limiting treatment access (cost, stigma, health care system navigability, and lack of childcare or transportation).
The utility model provides a medicine sponge cork used for treating vaginal diseases. Traditional Chinese medicine for clearing heat, promoting diuresis, destroying parasites and relieving itching, the extracting solution of phellodendron bark, flavescent sophora root, cnidium fruit, broom cypress fruit, Chinese gall, white alum, cockscomb flower and yam rhizome is soaked in a polyurethane sponge cork which is defatted. The polyurethane sponge cork dried by aeration forms an elliptical column shape or a column shape. When the sponge cork is used, the sponge cork can release the medicine for treating the diseases for a long time. Moreover, vaginal secretion can be absorbed in the sponge cork for disinsection and sterilization. And the medicine is protected form external flow. The therapeutic effect is remarkably raised.
An electrically addressable release pad for use in a burst electrode drug release (delivery) system. The pad useable in this system comprises a polymer, preferably polypyrrole, which surrounds medicine. Once a section of the polymer receives an electrochemical potential sent from an electrode contained within the pad, a defined dose of medicine contained therein is released. The pad is designed to be worn by a patient, so that when the medication is released, its administered to the patient, without the patient having to do anything. The electrode typically can be a burst electrode, one with a unique electrical signature. The electrode can be triggered from a remote source.
The invention relates to a non-alkaline ganciclovir injection and a preparation method thereof. The pH value of the product solution is 7.4+/-0.4. The injection is prepared from 2-5 parts of ganciclovir, 2-25 parts of sulfobutyl ether-beta-cyclodextrin, 50-200 parts of water for injection and a proper amount of other additives. The preparation method comprises the following steps: firstly, preparing a soluble compound solution of ganciclovir and sulfobutyl ether-beta-cyclodextrin; then adding a pH regulating agent (or not adding), dissolving, sterilizing and filtering to obtain concentrated injection, or further preparing a lyophilized powder injection. According to the preparation method, multiple effects can be achieved by using only one cyclodextrin inclusion material, i.e., the solubility of ganciclovir can be sufficiently increased, the ganciclovir can be more stable, stimulation caused by using sodium hydroxide and other strong alkali can be avoided, and the injection can be used as filler, a supporting agent even a protective agent when frozen and dried. Therefore, the safety can be improved, the formula and the process can be simplified, and the non-alkaline ganciclovir injection is beneficial to clinical application and advantageous to industrial production.
The clobetasol group was treated with clobetasol propionate 0.05%, while the anti-inflammatory group was treated with mouthwash. The drug used consisted of Clobetasol propionate 0.05%, Ethyl alcohol 96° (50%), Hydroxyethylcellulose (4%); Preserved water (just enough to 100%) that was topically applied \[11\]. This drug was produced as a galenic formulation. Clobetasol propionate twice a day (every 12 hours) to the lesions with a soft bristle brush and were advised not to drink or eat during the hour following application of the medication.
BACKGROUND: The triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein (hsCRP) are the commonly used biomarkers for insulin resistance and systemic inflammation, respectively. We aimed to investigate the combined association of TyG and hsCRP with the major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS).
METHODS: A total of 9421 patients with CCS were included in this study. The primary endpoint was defined as a composite of MACE covering all-cause death, nonfatal myocardial infarction, and revascularization.
RESULTS: During the 2-year follow-up period, 660 (7.0%) cases of MACE were recorded. Participants were divided equally into three groups according to TyG levels. Compared with the TyG T1 group, the risk of MACE was significantly higher in the TyG T3 group. It is noteworthy that among patients in the highest tertile of TyG, hsCRP >3 mg/L was significantly associated with an increased risk of MACE, whereas the results were not significant in the medium to low TyG groups. When patients were divided into six groups according to hsCRP and TyG, the Cox regression analysis showed that patients in the TyG T3 and hsCRP >3 mg/L group had a significantly higher risk of MACE than those in the TyG T1 and hsCRP ≤3 mg/L group. However, no significant interaction was found between TyG and hsCRP on the risk of MACE.
CONCLUSION: Our study suggests that the concurrent assessment of TyG and hsCRP may be valuable in identifying high-risk populations and guiding management strategies among CCS patients.