anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Virtual reality (SG) creates a virtual environment that reflects a real environment and offers various experiences to users. Motion sickness can be observed in people after using virtual reality applications or simulation devices in education. There are questionnaires in the literature such as "Simulator Sickness Questionnaire" and "Motion Sickness Questionnaire". However, these questionnaires are specific surveys to evaluate symptoms that develop after vehicle handling or use of simulation devices for pilot training, while they are not ideal questionnaires to evaluate symptoms that may develop after virtual reality applications. Because there are important differences between virtual reality systems and simulation systems in terms of the appearance of motion disturbance symptoms. For this reason, "Virtual Reality Sickness Questionnaire" has been developed that can evaluate these symptoms.

There is no Turkish version of the "Virtual Reality Sickness Questionnaire" in the literature. For this reason, this study is planned for the cultural adaptation and validity of the "Virtual Reality Sickness Questionnaire".
Nondystrophic myotonias are muscle disorders caused by abnormal muscle cell membrane proteins that affect the control of muscle fiber contraction. These disorders are extremely rare, and little is known about how to best treat the various subtypes of NDM. The purpose of this study is to characterize the clinical features and symptoms of NDM as well as to pair this data with specific NDM subtypes. In turn, this may lead to the development of improved treatments. The study will also establish clinical endpoints for use in future studies.

This multi-center observational study will involve both a cross-sectional data analysis and a prospective longitudinal analysis. Participants will initially attend a one-day outpatient study visit. Various baseline measurements will be collected, including demographics, medical history, and quality of life measures. Blood samples will be taken to evaluate laboratory values and genetic factors. Participants will undergo manual muscle testing (MMT), clinical myotonia assessments, and functional movement assessments. Routine nerve conduction studies and electromyography (EMG) will also be performed in order to test for the presence of myotonia in specific muscles. Annual follow-up evaluations will occur 1 and 2 years following the first study visit.
Novel cpds. (I) which are di-carbocyclic or heterocyclic carboxylic acid esters of a piperidinol or corresp. amide contg. an alkylene bridge or esters or amides of a substd. benzoic acid and a piperidinol or piperidyl amine contg. an alkylene bridge have the following structural characteristics (a) each benzoic acid ester which possesses an alkylene bridge between 2C atoms of the piperidyl ring is substd. in the Ph ring in at least one of the ortho or meta positions (b) in each benzoic acid ester which is unsubstd. in both ortho-positions of the Ph ring or which is substd. by halogen or alkyl in at least one of the ortho-positions but possesses only H or halogen in meta- and para-positions and which possesses an alkylene bridge between 2-ring C of the piperidyl ring, this alkylene bridge contains at least 3C (c) in each benzoic acid ester which contains an oxy gp. and which possesses an alkylene bridge between the N atom of the piperidyl ring and a ring C atom, there is at least one substituent other than oxy or only 2 oxy substituents in the benzoic acid nucleus (d) in each mono-cyclic or heterocyclic carboxylic acid amide or ester in which the heterocycle is a 6-membered ring, or in each cyclic hetero-cyclic carboxylic acid amide in which the heterocycle contains 2 O atoms, there is an alkylene bridge in the piperidyl ring between a piperidyl N-atom and a piperidyl C atom (e) in each benzoic acid amide, the alkylene bridge of the piperidyl ring is attached to a ring C and the ring N (f) in no benzoic acid amide is there an alkyl, OH or halogen substit. in the ortho-position (g) thienoyl and naphthoyl-8-aza-bicyclo (3,2,1) oct-3-yl esters are excluded. The salts of these cpds., e.g. their acid addn. salts and quat. ammonium salts e.g. of the N atom of the piperidyl ring are also new.
Post-acute sequelae of COVID-19 (PASC), or Long COVID, is a chronic condition following acute SARS-CoV-2 infection. Symptoms include exertion fatigue, respiratory issues, myalgia, and neurological manifestations such as 'brain fog,' posing concern for their debilitating nature and potential role in other neurological disorders. However, the underlying potential pathogenic mechanisms of the neurological complications of PASC is largely unknown. Herein, we investigated differences in antigen-specific T cell responses from the peripheral blood towards SARS-CoV-2, latent viruses, or neuronal antigens in 14 PASC individuals with neurological manifestations (PASC-N) versus 22 individuals fully recovered from COVID-19. We employed Activation Induced Marker (AIM), ICS and FluoroSpot assays to determine the specificity and magnitude of CD4+ and CD8+ T cell responses towards SARS-CoV-2 (Spike and rest of proteome), latent viruses (CMV, EBV), and several neuronal antigens. Overall, we observed similar antigen-specific T cell frequencies and cytokine effector T cell responses between PASC donors compared to recovered controls for all antigens tested (viral or autoantigen) in both CD4+ and CD8+ T cell compartments. Our findings suggest that PASC-N does not appear to be associated with changes in antigen-specific T cell responses towards a subset of disease-relevant targets, but more studies in a larger cohort are needed to confirm these unaltered responses.
Bruton tyrosine kinase (BTK) is a kinase expressed by various immune cells and is often activated under proinflammatory states. Although the majority of BTK-related research has historically focused on B cells, understanding the role of BTK in non-B cell populations is critical given myeloid cells also express BTK at comparable levels. In this study, we investigated and compared how BTK inhibition in human and murine myeloid cells alters cell phenotype and function. All experiments were performed using two BTK inhibitors (evobrutinib and tolebrutinib) that are currently in late-stage clinical trials for the treatment of multiple sclerosis. Assays were performed to assess the impact of BTK inhibition on cytokine and microRNA expression, phagocytic capacity, and cellular metabolism. In all cells, both evobrutinib and tolebrutinib significantly decreased phosphorylated BTK and LPS-induced cytokine release. BTK inhibition also significantly decreased the oxygen consumption rate and extracellular acidification rate in myeloid cells, and significantly decreased phagocytosis in murine-derived cells, but not human macrophages. To further elucidate the mechanism, we also investigated the expression of microRNAs known to impact the function of myeloid cells. BTK inhibition resulted in an altered microRNA expression profile (i.e., decreased miR-155-5p and increased miR-223-3p), which is consistent with a decreased proinflammatory myeloid cell phenotype. In summary, these results provide further insights into the mechanism of action of BTK inhibitors in the context of immune-related diseases, while also highlighting important species-specific and cell-specific differences that should be considered when interpreting and comparing results between preclinical and human studies.
Objective: This study aimed to investigate the effect of a virtual reality (VR)-mediated gamified rehabilitation program added to a home exercise program on pain, functionality, and quality of life in shoulder impingement syndrome. Methods: Forty-eight participants with shoulder impingement syndrome were included in this prospective, randomized, single-blind study between January and July 2022. The participants were randomized into two groups: the VR group (n = 24) and the control group (n = 24). All participants were given a home exercise program for 3 weeks, with five sessions per week. The participants in the VR group received 15 sessions (45 minutes each session) of a gamified shoulder exercise program with an immersive VR headset, while those in the control group received 15 sessions (45 minutes each session) of supervised therapeutic exercises. The participants were evaluated and compared before and after treatment using the 36-item Short Form Survey (SF-36), range-of-motion (ROM) measurements, the Visual Analog Scale (VAS), and the Shoulder Pain and Disability Scale (SPADI). Results: At the baseline assessment, the two groups were homogenous regarding demographic and clinical parameters. The post-treatment shoulder extension and adduction ROM was significantly greater in the VR group and the post-treatment pain subscales for SPADI and SF-36 were significantly lower in the VR group. Conclusion: In individuals with shoulder impingement syndrome, a VR-mediated gamified exercise program added to a home exercise program increased shoulder ROM and reduced pain scores. Further clinical studies are needed to prove the long-term efficacy of the addition of VR-mediated gamified exercises to the treatment of this condition in clinical settings.
The patient care system is computer based in which a screen display provides a pull down menu that list items ranging from catheter requirements, nursing requirement and medical treatment. Selection of any item results in an on screen display of the different options for catheterisation (4-11). The locations of catheter functions are indicated by the cursor in relation to icons on a body symbol. For treatment a range of organ symbols are displayed on the screen and a time scale indicates different requirements. A similar display indicates nursing care requirements. ADVANTAGE - Provides reliable, structured plane and documentation.
BACKGROUND: The inflammatory burden index (IBI), a novel inflammation-based indicator, to is associated with the presence and prognosis of various diseases. However, few studies have focused on exploring the relationship between IBI and the coronary slow flow phenomenon (CSFP). In this study, we aimed to investigate the predictive value of IBI for CSFP in patients with chest pain and no obstructive coronary artery disease.
METHODS: A total of 1126 individuals with chest pain and no obstructive coronary arteries were consecutively included in this study. 71 patients developed CSFP were included in the CSFP group. A 1:2 age- and sex-matched patient with normal blood flow and angiographically proven normal coronary arteries was selected as the control group (n = 142). Plasma C-reactive protein (CRP), neutrophil, and lymphocyte counts were measured to determine the value of IBI.
RESULTS: The IBI were significantly higher in the CSFP group than in the controls (21.1 ± 6.5 vs. 14.5 ± 6.4, P < 0.001). The IBI increasedelevated with the increase of the numbers of vessels affected by CSFP. Multivariate logistic regression analysis revealed that IBI and body mass index (BMI) were independent predictors of CSFP. Receiver operating characteristic (ROC) curve analysis showed that when IBI was > 15.74, the sensitivity and specificity were 77.5% and 67.6%, respectively, and the area under the ROC curve (AUC) was 0.799 (95% CI: 0.737-0.862, P<0.001).
CONCLUSION: The IBI may be an independent predictor of CSFP in patients with chest pain and normal coronary arteries. The IBI could improve the predictive value of CSFP compared with the indicators alone.
PURPOSE:To obtain the extract of MANNENTAKE (Fomes japonicus, a kind of fungi) composed of the solvent extract of the mycelia of MANNENTAKE cultured in a specific medium or of the concentrate of the culture liquid after the separation of the mycelia, positive to ninhydrin reaction and Fehling reaction, etc., and containing the component resembling closely to the natural fruiting body of MANNENTAKE. CONSTITUTION:The seed mycelia of MANNENTAKE is cultured in a liquid medium containing 0.2-10W/V% glucose and 0.2-2W/V% wheat embryo. The cultivation is carried out by inoculating about 5-10mg of the mycelia to 100ml of the liquid medium, and stirring the medium at 200-300rpm and 25-30 deg.C under aeration of 0.5- 3.0V.V.m. in a dark place for 7-21 days. After cultivation, the cultured product or the mycelia separated from the cultured product is extracted with a solvent, or the cultured liquid left after the separation of the mycelia therefrom is concentrated to obtain the objective extract of MANNENTAKE. The extract is relatively stable at about <=60 deg.C, contains the components having close resemblance to the natural fruiting body of MANNENTAKE, and exhibits excellent effect such as nutrient, tonic, brain refreshing, anti-inflammatory, diuretic effects, etc. as a health food.
PURPOSE: A composition containing metformin and melatonin for preventing or treating diabetes is provided to enhance anti-diabetic activity. CONSTITUTION: A composition for preventing or treating diabetes contains melatonin and metformin as an active ingredient. A pharmaceutical composition for preventing or treating diabetes contains metatonin and metformin as an active ingredient. The pharmaceutical composition additionally contains pharmaceutically acceptable carrier. Metformin and melatonin are administered in 100 mg/kg each. The pharmaceutical composition is taken by oral administration or parenteral administration.
The invention comprises compounds of the formula: <FORM:0854631/IV(b)/1> (wherein R is an aryl radical which may be substituted by one or more halogen atoms or alkyl groups, R1 is a hydroxy, alkoxy, dialkylaminoalkoxy, mercapto or alkylmercapto group and R2 is hydrogen, an alkyl radical or, if R1 is a free hydroxy or mercapto group, also a free hydroxy or mercapto group respectively, the alkyl radicals each containing at most 7 carbon atoms) including tautomers thereof; and salts thereof.  The compounds containing free hydroxy groups may be prepared by reacting a 5-unsubstituted 2-aryl-3-amino-pyrazole-4-carboxylic acid or an ester or the amide thereof with formamide or urea or an alkane carboxamide, or the amide of the pyrazole carboxylic acid with an alkane carboxylic acid or reactive derivative thereof. p  Hydroxy groups in the resulting products may subsequently be replaced by chlorine atoms and the chloro compounds reacted with a metal alcoholate or mercaptide or a metal hydrosulphide or thiourea to introduce alkoxy, mercapto or alkylmercapto groups, or the free hydroxy groups may be substituted directly, for example by reaction with alkyl or dialkylaminoalkyl halides.  Metal salts of the free hydroxy or mercapto compounds may be made, and basic compounds may be converted to salts with inorganic or organic acids, an extensive list of which is given.  Examples describe the preparation of 1-phenyl-4-hydroxy-pyrazolo-(3 : 4-d)-pyrimidine and the corresponding 4-methoxy, 4-mercapto, 4-dimethylaminoethoxy and 4 : 6-dihydroxy compounds and of 1-phenyl-4-hydroxy-6-methyl-and 1-(p-chlorophenyl)-4-hydroxy-pyrazolo-(3 : 4-d)-pyrimidines. hydrochloride of one of the products is also described. Specifications 854,632, 854,633 and 854,634 are referred to.ALSO:Pharmaceutical preparations comprise compounds of the formula:  <FORM:0854631/VI/1> (wherein R is an aryl radical which may be substituted by one or more halogen atoms or alkyl groups, R1 is a hydroxy, alkoxy, dialkylaminoalkoxy, mercapto or alkylmercapto group and R2 is hydrogen, an alkyl radical or, if R1 is a free hydroxy or mercapto group, also a free hydroxy or mercapto group respectively, the alkyl radicals each containing at most 7 carbon atoms) including tautomers thereof, and salts thereof, in admixture with conventional pharmaceutical inorganic or organic excipients suitable for enteral, parenteral or topical administration in forms such as tablets, dragees, salves, creams, solutions, suspensions or emulsions.  They may contain preserving, stabilizing, or emulsifying, wetting agents and other therapeutically valuable substances.  Specified salts are hydrohalides, sulphates, nitrates, perchlorates, phosphates, formates, acetates, propionates, lactates, oxalates, succinates, malates, tartrates, citrates, ascorbates, benzoates, salicylates, p-aminosalicylates and methane-, ethane-, hydroxyethane-, toluene- and naphthalene-sulphonates.  Specifications 854,632, 854,633 and 854,634 are referred to.
Two capsules of placebo (devoid of microorganisms) per day. Patients took their daily dose 2h after breakfast and antibiotic administration each day. Patients were then followed for an additionnal 21 days after completion of the assigned intervention.
A fiber optic probe placement guide minimizes sampling errors during optical sampling of a tissue measurement site by allowing repeatable placement of the fiber optic probe (33) at a targeted tissue measurement site. A mount (11), contoured to conform to the shape of the tissue measurement site, typically the arm of a human subject, contains an aperture (14) for receiving a fiber optic probe. A temperature probe (15) on the contact surface of the guide allows for monitoring of surface temperature within the vicinity of the tissue measurement site. Crosshair slots (22) in the mount align with corresponding crosshairs at the tissue measurement site. The fiber optic probe placement guide is affixed to the tissue measurement site by means of adhesive tape (38) or fastenable straps. Guideposts (21) on the external surface of the mount are received by corresponding receptacles (32) on a subject interface bearing the fiber optic probe to facilitate alignment of the fiber optic probe (33) with the aperture (14).
Immunomagnetic particles are extensively used for the separation of biological molecules and particles, and have exhibited great potential in many fields including biosensors, disease diagnosis and biomedical engineering. However, most immunomagnetic particles exhibit a smooth surface, resulting in a limited separation efficiency for biological particles featuring enormous surface nanostructures, such as tumor cells. Here we report flower-like immunomagnetic particles (FIMPs) prepared by streptavidin (SA)-assisted biomineralization and one-step antibody modification, and demonstrate their superior capability for highly efficient and selective separation of circulating tumor cells (CTCs). SA can link inorganic nanosheets and magnetic nanoparticles together to obtain FIMPs with programmable hierarchical flower-like nanostructures and provide enormous binding sites for post-antibody modification. The synergetic effect of nano-sized petals and micro-sized particles in the hierarchical nanostructure enhances the interaction between the cells and the matrix, thus enabling FIMPs to separate CTCs with high selectivity and high efficiency. Our study provides a promising platform for the selective separation of trace biological molecules and particles from complex samples and shows great potential for downstream detection and diagnosis.
This study explores the role of inflammation and oxidative stress, hallmarks of COVID-19, in accelerating cellular biological aging. We investigated early molecular markers-DNA methylation age (DNAmAge) and telomere length (TL)-in blood leukocytes, nasal cells (NCs), and induced sputum (IS) one year post-infection in pauci- and asymptomatic healthcare workers (HCWs) infected during the first pandemic wave (February-May 2020), compared to COPD patients, model for "aged lung". Data from questionnaires, Work Ability Index (WAI), blood analyses, autonomic cardiac balance assessments, heart rate variability (HRV), and pulmonary function tests were collected. Elevated leukocyte DNAmAge significantly correlated with advancing age, male sex, daytime work, and an aged phenotype characterized by chronic diseases, elevated LDL and glycemia levels, medications affecting HRV, and declines in lung function, WAI, lymphocyte count, hemoglobin levels, and HRV (p < 0.05). Increasing age, LDL levels, job positions involving intensive patient contact, and higher leukocyte counts collectively contributed to shortened leukocyte TL (p < 0.05). Notably, HCWs exhibited accelerated biological aging in IS cells compared to both blood leukocytes (p ≤ 0.05) and NCs (p < 0.001) and were biologically older than COPD patients (p < 0.05). These findings suggest the need to monitor aging in pauci- and asymptomatic COVID-19 survivors, who represent the majority of the general population.
PURPOSE:To obtain the title film capable of protecting hair damage along with retaining and restoring hair performance by forming alkali-soluble films on both the upper and lower surfaces of a film consisting mainly of water-soluble natural sugar and plasma. CONSTITUTION:The objective film can be obtained by forming alkali-soluble films on both the upper and lower surfaces of a film or thin layers as the chief constituent consisting mainly of a water-soluble natural sugar (e.g. glucose, dextran, pullulan) and plasma or plasma substitute (e.g. polyvinylpyrrolidone) or one of them. Alternatively, the objective film can be obtained by forming acid-soluble or hot-melt type films on both the upper and lower surfaces of a film or thin layer as the chief constituent consisting mainly of at least one of the above-mentioned water-soluble natural sugar, plasma and plasma substitute. Addition of polyvinyl alcohol to the above chief constituent will improve the flexibility of the final film, making the film easier to handle.
The invention discloses a preparation method of a health-care apple-juice tea wine. The wine is prepared from the raw materials of, by weight: 40-50 parts of apple, 10-15 part of olive, 8-14 parts of green tea, 80-110 parts of glutinous rice wine, 5-8 parts of wampee, 2-3 parts of purple common perilla, 2-4 parts of Japanese galangal rhizome, 2-3 parts of hawthorn fruit, 1-2 parts of licorice root, 2-3 parts of sunflower leaf, 1-2 parts of henbit deadnettle herb, 2-3 part of canton abrus herb, 1-2 parts of jasmine, 1-2 parts of grape root, 10-15 parts of red lees, 5-10 parts of brown sugar, and proper amount of water. According to the invention, apple and olive in the formula are rich in various beneficial components such as vitamins and mineral elements, such that the wine is beneficial for health. Also, canton abrus herb is added, such that heat-clearing, inflammation-eliminating, detoxifying, and liver-soothing effects are provided. Henbit deadnettle herb assists in reducing blood pressure, reducing blood fat, and protecting and benefiting liver. The wine is reasonably formulated, and has brain-invigorating, intelligence-promoting, heat-clearing, lung-moistening, yang-nourishing, and beautifying functions. The food is nutritional, and has health-care function and unique taste.
After Institutional Review Board approval, It recruits 2 groups. one group is elderly and another group is stroke survivors. the stroke group that meets the criteria. Another group is age matching of the stroke and not having an orthopedic or neurological disease. Participants of all the groups are assessed for kinematic by motion capture During reaching arm(affected side; stroke group, non-dominant side; healthy group) in 3 directions(medial_45, forward_90 and lateral_135 degrees). Retroreflective markers are placed on 11 anatomical place (3th metacarpal joint, both acromion, elbow lateral and medial epicondyle, lateral and medial styloid process, xyphoid process, sternum, C7, T4). Participants reach to a bell as quickly as possible in three directions. The subject reach to a bell 5 times in each direction and assess clinical evaluation such as Fugl Meyer Assessment, Postural Assessment Scale, Modified Ashworth Scale, shoulder-elbow range of motion and Trunk Instability scale.