anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides traditional Chinese medicine lotion for treating hemorrhoids. The traditional Chinese medicine lotion for treating the hemorrhoid is prepared from the following traditional Chinese medicine materials: gallnut, sophora flower, cortex lycii radices, alum, Momordica cochinchinensis, folium artemisiae argyi, loranthus parasiticus, pepper, plantain seed, radix angelicae, Ailanthus altissima Swingle, fructus aurantii, honeysuckle, cimicifugae foetidae, smoked plum, radix sophorae flavescentis, blackberry lily, fructus cannabis, Scutellaria baicalensis, Ammannia baccifera, hedgehog hide, rheum officinale, hairyvein agrimony, pagoda tree fruit, Cacumen biotae, peach kernel, herba portulacae, cinnabar, Ligusticum wallichii, bezoar, safflower carthamus, leech, Polygonum cuspidatum, borneol, duckweed and mongolian oak leaf. The traditional Chinese medicine lotion for treating the hemorrhoids has effects of removing heat to cool blood, stopping bleeding and astringing and promoting blood circulation to remove blood stasis by the compatibility of all the traditional Chinese medicines. Symptoms and root causes of the hemorrhoids with various symptoms can be treated by the traditional Chinese medicine composition. Proved by observation, a clinical effect is exact, reliable and real. The traditional Chinese medicine lotion provided by the invention is non-toxic and harmless, is safe and reliable and is safe in clinical use, and no adverse reaction is generated after fumigation and washing.
Researchers have started exploring that neural tissue mobilization along with conventional treatment is more effective in decreasing pain and improving cervical range of motion and mental component of quality of life in unilateral cervical radiculopathy (CR) patients than intermittent cervical traction and conventional treatment. Future randomized controlled trials are warranted with the purpose to compare the long-term effectiveness of cervical traction with neural mobilization in CR, as well as the effect of these two techniques in comparison with other interventions. Some literature recommended the simultaneous application of mechanical cervical traction along with neural mobilization in the treatment of Unilateral Cervical Radiculopathy. There are numerous studies in which both groups received Cervical traction (CT) and neural mobilization (NM) was added in only one group along with cervical traction or studies in which both groups received NM and CT was administered in only one group as well, there are also some studies in which one group received only CT and other group received only NM but there isn't any study yet in which we can compare the effect of simultaneous administration of CT and NM and consecutive administration of CT and NM.

Pain and functional limitation in cervical radiculopathy can be treated with mechanical cervical traction and neural mobilization. The purpose of the study is to determine that is simultaneous administration of cervical traction and neural mobilization is more effective than consecutive administration in the management of cervical radiculopathy. The findings of the study will provide an insight into the low-cost evidence-based conservative management of cervical radiculopathy.
A prospective study including 180 consecutive patients with PCa referred to Oslo University Hospital, Radiumhospitalet, for surgical treatment. In vivo functional MRI examination will be performed within a few days prior to robot-assisted radical prostatectomy (RALP). For a subgroup of patients FACBC PET will also be acquired prior to prostatectomy. A subgroup of intermediate and high-risk patients (D'Amico risk classification) will prior to surgery receive an intravenous infusion of the hypoxia-marker pimonidazole (Hypoxyprobe™-1)\*. During surgery, bone marrow aspiration and blood collection will be performed for assessment of disseminated and circulating tumor cells. High-risk patients will undergo intraoperative lymph node dissection. Tumor tissue for molecular analyses will be sampled from prostate specimen prior to fixation. Prostate specimen and regional lymph nodes will be histopathologically examined for T- and N-classification, Gleason grade, presence of micrometastasis and areas of hypoxia. Histological and molecular findings will be correlated to MRI and PET findings and clinical data. Patients will be longitudinally followed to assess long-time clinical outcome (recurrence, metastatic disease, death).

\*From 2013 oral administration is used.
A computer system is provided. The system includes a computing device including at least one data processor and at least one computer readable storage medium storing computer-executable instructions. The system further includes a device configured to communicate with the computing device and having a display. The at least one data processor is configured to execute the computer executable instructions to perform operations. The operations including displaying, using the at least one data processor and on the display, a first eye condition assessment or eye condition correction activity of a plurality of eye condition assessments or correction activities configured to measure one or more visual skills of a user. The operations further include receiving, by the at least one data processor, user input with respect to the first eye condition assessment or eye condition correction activity. The operations further include determining whether a target value of at least one parameter has been reached.
Participants will undergo screening with basic physical exam and lung function testing at the start of the study. Participants will then inhale a radiolabeled substance and undergo medical imaging to measure the clearance of mucus in the airways. Albuterol will be administered after the first imaging is completed. Lung function testing will be repeated. Finally, medical imaging will be repeated two more times to further look at clearance of mucus in the lungs. The study will be completed in one day and will last about 6 hours.
The microbiome includes both 'mutualist' and 'pathogen' microbes, regulated by the same innate immune architecture. A major question has therefore been: how do hosts prevent pathogenic infections while maintaining beneficial microbes? One idea suggests hosts can selectively activate innate immunity upon pathogenic infection, but not mutualist colonization. Another idea posits that hosts can selectively attack pathogens, but not mutualists. Here I review evolutionary principles of microbe recognition and immune activation, and reflect on newly observed immune effector-microbe specificity perhaps supporting the latter idea. Recent work in Drosophila has found a surprising importance for single antimicrobial peptides in combatting specific ecologically relevant microbes. The developing picture suggests these effectors have evolved for this purpose. Other defence responses like reactive oxygen species bursts can also be uniquely effective against specific microbes. Signals in other model systems including nematodes, Hydra, oysters, and mammals, suggest that effector-microbe specificity may be a fundamental principle of host-pathogen interactions. I propose this effector-microbe specificity stems from weaknesses of the microbes themselves: if microbes have intrinsic weaknesses, hosts can evolve effectors that exploit those weaknesses. I define this host-microbe relationship as 'the Achilles principle of immune evolution'. Incorporating this view helps interpret why some host-microbe interactions develop in a coevolutionary framework (e.g. Red Queen dynamics), or as a one-sided evolutionary response. This clarification should be valuable to better understand the principles behind host susceptibilities to infectious diseases. This article is part of the theme issue 'Sculpting the microbiome: how host factors determine and respond to microbial colonization'.
BACKGROUND: The economic crisis that began in 2008 has severely affected Southern (Greece, Italy, Portugal, Spain) Western European (SWE) countries of Western Europe (WE) and may have affected ongoing efforts to eliminate viral hepatitis. This study was conducted to investigate the impact of the economic crisis on the burden of HBV and HCV disease.
METHODS: Global Burden of Diseases 2019 data were used to analyse the rates of epidemiological metrics of HBV and HCV acute and chronic infections in SWE and WE. Time series modelling was performed to quantify the impact of healthcare expenditure on the time trend of HBV and HCV disease burden in 2000-2019.
RESULTS: Declining trends in incidence and prevalence rates of acute HBV (aHBV) and chronic HBV were observed in SWE and WE, with the pace of decline being slower in the post-austerity period (2010-2019) and mortality due to HBV stabilised in SWE. Acute HCV (aHCV) metrics and chronic HCV incidence and mortality showed a stable trend in SWE and WE, whereas the prevalence of chronic HCV showed an oscillating trend, decreasing in WE in 2010-2019 (p < 0.001). Liver cancer due to both hepatitis infections showed a stagnant burden over time. An inverse association was observed between health expenditure and metrics of both acute and chronic HBV and HCV.
CONCLUSIONS: Epidemiological metrics for HBV and HCV showed a slower pace of decline in the post-austerity period with better improvement for HBV, a stabilisation of mortality and a stagnant burden for liver cancer due to both hepatitis infections. The economic crisis of 2008 had a negative impact on the burden of hepatitis B and C. Elimination of HBV and HCV by 2030 will be a major challenge in the SWE countries.
The aim of the study is to compare the effects of reduced-exertion high-intensity training (REHIT) versus short moderate-intensity training (SMIT) on functional capacity, resting heart rate (RHR), and activity enjoyment in sedentary young women. Therefore, sedentary young women will be randomly allocated to either a: i) REHIT group or ii) SMIT group. Both groups will perform an intervention over 6 weeks duration for 10 minutes each session for 2 sessions/week, but with different intensities (REHIT or SMIT). Both forms of exercise will be conducted on a cycle ergometer with the subjects monitored throughout the intervention. Before and after the 3-week intervention, functional capacity (6-minute walking test) and RHR will be measured. Additionally, physical activity enjoyment (Physical Activity Enjoyment Scale) will be assessed after the intervention.
A system for entering physical documents into an electronic data store includes a host server system having a computer processor and associated memory, including the electronic data store, a data entry system including a computer processor and associated memory and a provider system including a computer processor and associated memory. The data entry system transmits instructions to the host server system to generate a token including destination information for physical documents being entered into the electronic data store. The host server system includes a token generation system for generating the token, the token including the destination information for physical documents being entered into the electronic data store. The host server system transmits the token to the data entry system. The data entry system generates a hard copy of the token and transmits an electronic version of the hard copy of the token to the provider system. The provider system receives the electronic version of the token, converts the electronic version back to the hard copy of the token, attaches the physical documents to be entered in the electronic data store to the hard copy of the token and electronically transmits the hard copy and the physical documents to the host server system. The host server system receives the electronic form of the electronically transmitted hard copy and physical documents, reads the token and enters the electronic form of the physical documents into the electronic data store based on the destination instructions.
PROBLEM TO BE SOLVED: To obtain a skin preparation which has a remarkably improved skin- whitening effect and high safety and is useful for external use, by adding the extract of Chutro (scientific name; Berberis nepalensis). SOLUTION: This skin preparation for external use contains the extract of Chutro (scientific name; Berberis nepalensis). The Chutro is a plant which belongs to the genus Berberis in the family Berberidaceae and has been used as a traditional galenical drug in Nepal. The extract of the Chutro is obtained by immersing or thermally refluxing the leaves, stems including subterranean stems, branches, barks, fruits, whole plant, and the like of the Chutro together with a proper extraction solvent, filtering and then concentrating the filtrate. The extract is added in an amount of preferably 0.001-20 wt.% more preferably 0.01-10 wt.%, pspecially preferably 0.1-7%, as a concentrated product or a dry product on the basis of the total amount of the preparation for external use for skin.  The preparation for external use for skin is preferably a beautifully skin-whitening agent for the external use.
One oral dose of dextroamphetamine (0.43 mg/kg) up to a maximum dose of 45mg. The dose is administered in 10mg and 2.5mg capsules prepared by the Vanderbilt Investigational Drug Services (IDS). Note: We are not testing the effect of dextro-amphetamine on a symptom. Rather it is part of the diagnostic intervention that is used to measure dopamine release assessed as the decline in \[18F\]fallypride binding relative to baseline.
PURPOSE:To obtain a medicated cream, containing an extract substance of Glycyrrhizae Radix, an extract solution of Phellodendri bark and further, as necessary, an extract solution of Sophora angustifolia Sieb. et Zucc. and effective for allergic disease, especially for dermatitides induced by the contact with materials such as metals, cosmetics or Japanese lacquer. CONSTITUTION:A medicated cream containing 0.05-0.5% extract substance of Glycyrrhizae Radix consisting mainly of glycyrrhetinic acid, 1-10% extract solution of Phellodendri bark and further, as necessary, 1-10% extract solution of Sophora angustifolia Sieb. et Zucc. Synergistic effects are exhibited by combining respective abilities of antiinflammatory action of the extract from the Glycyrrhizae Radix, wound surface curing promoting action and antiinflammatory action of the extract from the Phellondendri bark based on the astringent antiinflammatory action with berberine, alkaloids, etc., and ulcerogenic preventing ability of matrine which is a main alkaloid in the extract solution of the Sophora angustifolia Sieb. et Zucc., responding ability, etc., to skin infectious diseases, together with their individual effects.
Subacromial impingement (SAI) is associated with shoulder pain and dysfunction and is exacerbated by rotator cuff tears; however, the role of acromioplasty in mitigating subacromial contact in the rotator cuff deficient shoulder remains debated. This study aimed to quantify the influence of isolated and combined tears involving the supraspinatus on subacromial contact during abduction; and second, to evaluate the influence of acromioplasty on joint space size and subacromial contact under these pathological conditions. Eight fresh-frozen human cadaveric upper limbs were mounted to a computer-controlled testing apparatus that simulated joint motion by simulated force application. Shoulder abduction was performed while three-dimensional joint kinematics was measured using an optoelectronic system, and subacromial contact evaluated using a digital pressure sensor secured to the inferior acromion. Testing was performed after an isolated tear to the supraspinatus, as well as tears involving the subscapularis and infraspinatus-teres minor, both before and after acromioplasty. Rotator cuff tears significantly increased peak subacromial pressure (p < 0.001), average subacromial pressure (p = 0.001), and contact force (p = 0.034) relative to those in the intact shoulder. Following acromioplasty, significantly lower peak subacromial contact pressure, force and area were observed for all rotator cuff tears involving the supraspinatus at 30° of abduction (p < 0.05). Acromioplasty predominantly reduces acromion thickness anteriorly thereby reducing subacromial contact in the rotator cuff deficient shoulder, particularly in early to mid-abduction where superior glenohumeral joint shear force potential is large. These findings provide a biomechanical basis for acromioplasty as an intervention for SAI syndrome and as an adjunct to rotator cuff repairs.
A subset of participants (up to 40 caregiver-child pairs) who were assigned to the immediate PriCARE group will be offered to participate in the PriCARE Positive Discipline Module if they attended at least 4 PriCARE sessions and completed both main study interviews. If they are randomized to the immediate PriCARE Positive Discipline group, they will attend an additional 4-6 sessions 4-6 weeks after completion of the 6-week PriCARE intervention. This module teaches techniques related to behavior reward charts, appropriate timeout protocol, and other positive discipline techniques for handling persistent behaviors not addressed by the other PriCARE skills.
BACKGROUND: Chronic nonspecific cheilitis is a complex condition characterized by persistent lip peeling and discomfort. This case report explores the clinical progression of a patient with history of tongue squamous cell carcinoma and subsequent Tislelizumab treatment, presenting with persistent lip peeling.
CASE PRESENTATION: A patient with a history of tongue squamous cell carcinoma (T2N0M0), treated with chemotherapy, surgery, and Tislelizumab, presented with six months of persistent lip peeling. Clinical examination revealed distinct features of chronic nonspecific cheilitis with infectious angular cheilitis (Oral Candidiasis). A tailored treatment plan, emphasizing oral hygiene practices and local treatments with Sodium Bicarbonate, Tacrolimus ointment, and Chlortetracycline ointment. Follow-up visits demonstrated sustained improvement, highlighting the significance of individualized approaches.
CONCLUSIONS: This case underscores the importance of recognizing and managing oral manifestations in patients with a history of cancer and immunotherapy. The patient's response to treatment suggests that a multifaceted approach, combining local therapy with lifestyle modifications, can be effective in managing chronic nonspecific cheilitis associated with immunotherapy. Routine follow-up appointments, guided by personalized medicine principles, contribute to sustained patient well-being.
INTRODUCTION: Ureteroscopy has become increasingly chosen as a treatment of choice for patients with kidney stone disease and laser as the energy source for stone lithotripsy is a key part of this. Our aim was to analyse a national database to evaluate the burden of adverse events related to laser fibers and laser machines.
METHODS: Search was performed of the Manufacturer User and Facility Device Experience (MAUDE) database in the United States for all events related to holmium laser fibers and holmium laser machines during ureteroscopy between 2012-2021. Information collected included the following: problem, timing, prolonged anaesthesia, early termination of procedure, injury and retained parts.
RESULTS: 699 holmium laser fiber events were reported and these had been manufactured by 13 different companies. The commonest problems were breakage outside the patient while in use (26.3%) and breakage of the laser fiber tip (21.2%). Manufacturers concluded root cause to be device failure in 8.9%. 29% of issues occurred before the laser had been activated. 5.2% of cases had to be cancelled as a result of an event. Significantly more injuries were sustained intra-operatively by operating staff compared to patients (6% vs. 0.2%, p < 0.001). All these injuries were superficial burns to the skin with the hand being the most affected body part (88.1%). Zero ocular injuries were reported. Only eight events were related to laser machines and all involved sudden hardware failure but no patient injury.
CONCLUSIONS: Laser fibers are fragile. Most adverse events are due to operator error. Direct patient injury from laser fiber is scarce but operating staff should be aware of the risk of sustaining minor burns. Laser machines rarely incur problems and, in this study, did not result in any safety issues beyond need to abort the procedure due to lack of spare equipment.
Patients in the intervention arm will receive anakinra IV (N=85) 4 times a day for 7 days. The investigator will follow up with patients for up to 60 days.
The methylation of cytosines in CpG sites can have profound effects on the ability of genes to be transcribed. To clarify and distinguish the specific methylation changes responsible for overactive bladder (OAB) in those with insulin resistance (IR), the investigator will compare three well-characterized groups of women: 1) OAB and IR; 2) IR only (no OAB); and 3) OAB only (no IR). In this proposal the investigator is only studying women since they are more likely to be affected by OAB with incontinence, the investigator wants to study pure cohorts of patients, and because this is the clinical population cared for by the primary investigator. The plan for future investigations is to apply these findings to broader groups to better understand gender and racial differences.

In Specific Aim 1, the investigator will conduct an epigenome-wide association study (EWAS) study, followed by targeted validation studies to determine whether CpG sites throughout the genome are differentially methylated in well-characterized and matched cohorts, while controlling for the effects of insulin-resistance. In Specific Aim 2, the investigator will assess for differential expression of candidate loci in relation to methylation. RNA-sequencing (RNA-seq) will be used to establish differences in the transcriptome between extreme phenotypes of OAB+IR and OAB alone. The investigator will then use quantitative polymerase chain reaction (qPCR) to validate expression differences in all cohorts, and to confirm differences in candidate loci that are confirmed in experiments from Aim 1. The investigator will proceed with bioinformatic pathway analyses to identify the function and interdependence of genes with altered expression and altered methylation profiles. In Specific Aim 3, the investigator will determine whether expression (mRNA and protein) differences in voided urine cells are also exhibited in biopsied bladder mucosa. The investigator will use targeted assays to confirm similar methylation profiles and gene expression in voided cells and bladder biopsies. The investigator will also compare protein expression of candidate loci such as EXOC6, ZFC3H1, RPS6KA2, and SPON2 proteins, if confirmed in other Aims, between cohorts. When the proposed studies have been completed, it is the expectation that the investigator will have functionally characterized the methylation changes that the investigator preliminarily identified in IR associated OAB.
FIELD: animal science. SUBSTANCE: the method for stimulating reproductive functions in sows deals with enhancing biologically active centers N 5, 7, 11, 41, 44. Moreover, one should increase biological functions due to removal of one among five biologically active centers combined into single system with the help of atropine solution microinjections, and due to enhancing biological activity of other centers, as well. The suggested method provides higher percentage of conception rate as a result of the first insemination and could be applied for enhancing biological functions in sows. EFFECT: higher efficiency of stimulation. 1 dwg, 2 tbl