anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Neutrophils need to migrate through tight tissue spaces to eliminate pathogens, but their movement is often hindered by their large and stiff nuclei. Neutrophil migration is impaired in sepsis patients, but it is unclear whether this defect is related to the deformability of their nuclei. Herein, we designed microfluidic devices with micron-scale narrow slits to simulate biological barriers. This setup allowed us to observe and record neutrophil movement and nuclear deformation in real-time. We also developed a method for morphological analysis to quantify nucleus deformation in numerous individual cells. Our studies showed that neutrophils from healthy individuals could adjust their nuclear shape to squeeze through these constrictions, whereas those from sepsis patients demonstrated less flexibility. Neutrophils with rigid nuclei struggled to pass through narrow gaps and were more likely to rupture under pressure. These findings suggest that the migration defects of neutrophils observed in sepsis may be attributed to the inability of neutrophils to deform their nuclei, highlighting the crucial role of microfluidic technologies in offering new insights into migration defects under pathological conditions.
BACKGROUND: In recent years data-driven population segmentation using cluster analyses of mainly health care utilisation data has been used as a proxy of future health care need. Chronic conditions patterns tended to be examined after segmentation but may be useful as a segmentation variable which, in combination with utilisation could indicate severity. These could further be of practical use to target specific clinical groups including for prevention. This study aimed to assess the ability of data-driven segmentation based on health care utilisation and comorbidities to predict future outcomes: Emergency admission, A&E attendance, GP practice contacts, and mortality.
METHODS: We analysed record-linked data for 412,997 patients registered with GP practices in 2018-19 in Cwm Taf Morgannwg University Health Board (CTM UHB) area within the Secure Anonymised Information Linkage (SAIL) Databank. We created 10 segments using k-means clustering based on utilisation (GP practice contacts, prescriptions, emergency and elective admissions, A&E and outpatients) and chronic condition counts for 2018 using different variable compositions to denote need. We assessed the characteristics of the segments. We employed a train/test scheme (80% training set) to compare logistic regression model predictions with observed outcomes on follow-up in 2019. We assessed the area under the ROC curve (AUC) for models with demographic variables, with and without the segments, as well as between segmentation implementations (with/without comorbidity and primary care data).
RESULTS: Adding the segments to the model with demographic covariates improved the prediction for all outcomes. For emergency admissions this increased discrimination from AUC 0.65 (CI 0.64-0.65) to 0.73 (CI 0.73-0.74). Models with the segments only performed nearly as well as the full models. Excluding comorbidity showed reduced predictive ability for mortality (similar otherwise) but most pronounced reduction when excluding all primary care variables.
CONCLUSIONS: This shows that the segments have satisfactory predictive ability, even for varied outcomes and a broad range of events and conditions used in the segmentation. It suggests that the segments can be a useful tool in helping to identify specific groups of need to target with anticipatory care. Identification may be refined with selected diagnoses or more specialised tools such as risk stratification.
The invention discloses a kind of Chinese medicine composition treating syndrome of hyperactivity of fire due to deficiency of YIN renal tuberculosis. The traditional Chinese medical science thinks that renal tuberculosis is with consumptive disease worm for disease, many based on lung from the beginning of diseased region, with the passing of time through blood vessels invade and kidney and send out as kidney consumptive disease, with the passing of time deficiency of YIN affecting YANG, deficiency of QI and declination of YANG, often cause deficiency of spleen-YANG and kidneyYANG. The present invention selects have nourishing YIN to lower pathogenic fire, the Chinese medicine Rhizoma Tupistrae Chinensis of liver and kidney tonifying, Oreas martiana (Hopp. Et Hornsch.) Brid., Radix Anemones Rivularis, Herba Botrychii, Lindernia angustifolia (Benth.) Wettst., Folium Mori, Fructus Alismatis, Fructus Adinae, Herba Ecliptae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), make decoction, through clinical trial, total effective rate 96.7%, in therapeutic process, patient is showed no untoward reaction.
BACKGROUND: Kidney transplantation (KT) is the best treatment for patients with end-stage renal disease. However, postoperative complications remain the main issues faced during KT recovery period. Posttransplant lymphoproliferative disorders (PTLD) are one of the severe and life-threatening complications that occur after KT while the recipient is undergoing immunosuppressive therapy. PTLD risk factors include Epstein-Barr virus (EBV) infection, the cumulative degree of immunosuppression, as well as genetic aspects. PTLD is more common in the transplanted organ itself and its surroundings, and the central nervous system, while PTLD involving the pharyngeal soft tissue is relatively rare, with only a few reported case reports. Therefore, systematic experience is scarce regarding whether the treatment or the care.
CASE PRESENTATION: Herein, we report a 41-year-old male, underwent a reproductive KT due to chronic renal insufficiency. Recurrent fever, pharyngeal pain, and bilateral cervical lymph node enlargement were recurred during five years' follow-up after KT surgery. In this inpatient experience, the patient vomited a large amount of blood from the oropharynx, then the tonsil artery was ligated by emergency operation. EBV-associated T/NK cell monomorphic PTLD was eventually diagnosed by blood EBV DNA test, pharyngeal biopsy, and corresponding pathological examination. After six cycles of R-CHOP chemotherapy, the clinical symptoms and laboratory tests changed into normal. Subsequent three years' follow-up shows no tumor recurrence and good transplant kidney function.
CONCLUSION: This rare case report describes a manifestation of PTLD with pharyngeal involvement. Early diagnosis using histopathological examination is crucial to prevent damage to the throat and airway, and even life-threatening conditions. Discontinuing immunosuppression and starting systemic treatment can help in disease regression. Since the low incidence of this disease, limited clinical experience, and limited data, our experience with a smooth recovery through efficacy treatment and nursing can provide a reference for the development of new clinical drugs and diagnostic and treatment plans of patients with PTLD in the future.
Participants will have their wrist and hand immobilized using a rigid splint continuously for 7 days. The splint will restrict all wrist and hand movement and must be worn at all times for the full 7 day period, and may only be removed under supervision of the research participants.
Participants will participate in 7 lifestyle coaching sessions (two in the first month) over a 6 month period. The coaching sessions will be administered by phone.
Included patients will have F-MISO PET followed by brain MRI (MRI-1)(diffusion, FLAIR, perfusion, TOF) as soon as possible after stroke onset (less than 36 hours). A second brain MRI (MRI-2) will be performed on day 7.
The present invention provides a method for preparing submicron dragon blood powder. A fluidized bed airflow disintegrator set is adopted, the nozzle diameter is 4 millimeters, dry air is adopted as working gas, working pressure is from 6 to 7kg / cm <2>, the pitch of fractionation wheels is from 3.5 to 4.5 millimeters, the rotating speed of the fractionation wheels is from 8000 to 9000 circles / minute, and the particle diameter of dragon blood materials is less than 3 millimeters. The adopted working gas is cooled by liquid nitrogen firstly. The disintegrating method adopted by the present invention has the advantages of no grinding medium, no material pollution, low energy consumption and no environmental pollution. The original chemical components and the structure of dragon blood as traditional Chinese medicinal materials are not changed. The particle diameter range of obtained dragon blood granules is from 0.1 to 10 micrometres, the dragon blood granules with the particle diameter of less than 1 micrometre account for no fewer than 25%, and the average particle diameter of the dragon blood granules is 1.69 micrometres.
PROBLEM TO BE SOLVED: To suppress the radical generation when zinc oxide absorbs UV rays by treating zinc oxide particulates in a phosphoric acid solution to allow a phosphoric acid group to exist as zinc phosphate on particulate surfaces. SOLUTION: The zinc oxide particulates of <=1 μm in major axis are immersed in the dilute solution of phosphoric acid and are heated to about 80 deg.C, following which the solution is stirred and held for 1 to 5 hours. The solution is baked for 10 to 24 hours at 250 to 350 deg.C after filtering and washing with water, by which the zinc oxide particulates coated with the phosphoric acid group as zinc phosphate on the particulate surfaces at a thickness of 0.003 to 0.1 μm are obtained. The radical generation is suppressed without the impairment of the UV absorption characteristic and optical effect of the zinc oxide by this treatment. The surface treated zinc oxide particulates are preferably applied to materials used under exposure of light as cosmetics. The applications to cosmetics for sun care and makeup cosmetics, such as foundation, are preferable.  The particulates are also adequate for use with persons having the sensitive skin.
PURPOSE: To evaluate the precise origin of sensory nerves through gross anatomical study of the TFCC, synthesized alongside imaging and histological techniques.
METHOD: Six cadaveric forearm specimens were obtained to map the course and branches of the ulnar nerve through macrodissection. Immunohistochemical staining targeting PGP 9.5 and type IV collagen was performed on frozen TFCC sections to visualize nerve fibers microscopically. Computed tomography, magnetic resonance imaging, and arthrography findings were also reviewed.
RESULTS: At the macroscopic level, the articular branches supplying the TFCC originated predominantly from the dorsal branch of the ulnar nerve. Microscopic analysis revealed positive PGP 9.5 expression and discernible neural marker expression, signifying fine nerve fiber ingrowth within the TFCC. Imaging modalities aided the diagnosis of TFCC lesions. The dorsal cutaneous branch of the ulnar nerve, medial cutaneous nerve of the forearm, and volar sensory branch of the ulnar nerve emerged as the principal nerves innervating the TFCC.
CONCLUSIONS: This study provides anatomical evidence that the TFCC receives innervation from branches of the ulnar nerve and contains sensory nerve fibers. These findings enhance understanding of potential neuropathic pain mechanisms in TFCC injuries and offer insights to guide surgical interventions. Further investigations are warranted to elucidate the clinical implications.
PURPOSE: For breast cancer survivors (BCS) living with breast cancer-related lymphedema (BCRL), what outcome measures (OMs) are recommended to be used to measure standardized outcome domains to fully assess the burden of the disease and efficacy of interventions? An integral component of a standardized core outcome set (COS) are the OMs used to measure the COS.
METHODS: A supplemental online survey was linked to a Delphi study investigating a COS for BCRL. OMs were limited to a maximum of 10 options for each outcome domain (OD). There were 14 ODs corresponding to the International Classification of Functioning, Disability, and Health (ICF) framework and respondents rated the OMs with a Likert level of recommendation. The feasibility of the listed OMs was also investigated for most outpatient, inpatient, and research settings.
RESULTS: This study identified 27 standardized OMs with a few ODs having 2-3 highly recommended OMs for proper measurement. A few of the recommended OMs have limitations with reliability due to being semi-quantitative measures requiring the interpretation of the rater.
CONCLUSION: Narrowing the choices of OMs to 27 highly recommended by BCRL experts may reduce selective reporting, inconsistency in clinical use, and variability of reporting across interdisciplinary healthcare fields which manage or research BCRL. There is a need for valid, reliable, and feasible OMs that measure tissue consistency. Measures of upper extremity activity and motor control need further research in the BCS with BCRL population.
PURPOSE:To obtain a detergent which is creamy, has good foaming and conditioning effects and lowly irritates skin and hair by compounding a specified nonionic glycoside deriv. in the detergent. CONSTITUTION:A detergent compsn. contg. a nonionic glycoside deriv. of formula I wherein Gm is a sugar residue which remains after eliminating H atoms of all the non-glycoside and glycoside hydroxyl groups in a 5-6C reducing sugar or condensate thereof (wherein m is the degree of condensation and the means value is 1-10); the group A is an R<2>(OR<3>)Z group bonding to the sugar residue Gm via O-glycoside bond (wherein R<2> is a 6-22C linear or branched alkyl, etc.; R<3> alkylene; Z is a means value of 0-20); R<1> is a 2-4C alkylene; X is 0-10 in terms of (the total molar number of alkylene oxide molecules added to the non-glycoside hydroxyl group)/y; y is the number of non-glycoside hydroxyl group in the 5-6C reducing sugar; B is H, hydroxypropyl, formula II (wherein X is H or methyl), etc.
Patients suspect to be suffering from IUA will be recruited following a systematic pre-operative assessment process. This will include a detailed history of the menstrual pattern, previous intrauterine surgery, and reproductive history, as well as 3D transvaginal ultrasound. The severity and extent of intrauterine adhesions will be scored according to the AFS score. All patients will receive hysteroscopic adhesiolysis with the aid of ultrasound guidance as necessary. After adhesiolyis, the patients will assigned to two groups randomly,namely,the E-IUS(estrogen intrauterine stent system) group and the control group. Adhesion will be evaluated by hysteroscopy at second-look hysteroscopy before 60 after surgery.
Suggested Dosage: 1,200 mg to 3,200 mg daily (400 mg, 600 mg or 800 mg tid or qid). Individual patients may show a better responseto 3200 mg daily, as compared with 2,400 mg, although in well-controlledclinical trials patients on 3,200 mg did not show a better meanresponse in terms of efficacy. Therefore, when treating patients with 3,200 mg/day, the physician should observe sufficient increased clinicalbenefits to offset potential increased risk.The dose should be tailored to each patient, and may be loweredor raised depending on the severity of symptoms either at time of initiatingdrug therapy or as the patient responds or fails to respond.In general, patients with rheumatoid arthritis seem to require higherdoses of Ibuprofen tablets than do patients with osteoarthritis.

The smallest dose of Ibuprofen tablets that yields acceptable controlshould be employed. A linear blood level dose-response relationshipexists with single doses up to 800 mg (See CLINICAL PHARMACOLOGY for effects of food on rate of absorption).

The availability of three tablet strengths facilitates dosage adjustment.In chronic conditions, a therapeutic response to therapy with Ibuprofen tablets is sometimes seen in a few days to a week but most often isobserved by two weeks. After a satisfactory response has beenachieved, the patient’s dose should be reviewed and adjusted asrequired.
Disclosed is a method of treating a subject with a Wasting Syndrome. The method comprising the step of administering to the subject an effective amount of a compound represented by Structural Formula (I), Ar is a substituted or unsubstituted aryl group. Ar is preferably a monocyclic heteroaryl group or a fused polycyclic heteroaryl group. Ring A has zero, one or more additional substituents. R1 and R2 are independently -H or a C1-C4 alkyl group. W is -CH2-, -CH2CH2- or -CH2CH2CH2-. R3 is a substituted or unsubstituted phenyl or pyridyl group.
Compositions for oral administration to animals containing methyl salicylate. A premix of the methyl salicylate and a nutritional support is prepared and this is then incorporated into a feedstuff or into drinking water. The nutritional support preferably contains animal or vegetable gelatin, together with sugars and vegetable oils such as olive oil. An especially preferred support contains 20 - 45 % gelatin, 20 - 45 % water, 5 - 25 % glucose, and 5 - 25 % vegetable oil. Solid feedstuffs containing the premix preferably contain 0.4 - 1.1 g of methyl salicylate per kilogram. Drinking water containing the premix preferably contains 0.0001 - 0.02 % of methyl salicylate.
OBJECTIVE: This study aimed to elucidate the long-term impact of prelingual deafness and elderly age at cochlear implantation on cochlear implant (CI) programming parameters and CI thresholds METHODS: We retrospectively reviewed patients who underwent cochlear implantation less than 5 years (Prelingual group) and equal and more than 18 years in our institute. The latter group was further divided into Adult and Elderly groups according to whether the patient was younger or older than 65 at implantation. From 152, 69, and 55 patients in the Prelingual, Adult, and Elderly groups, 242, 92, and 58 ears were included. We compared CI thresholds and CI programming parameters, including impedances, T/C levels, and dynamic ranges for 8 years after implantation between the Prelingual, Adult, and Elderly groups.
RESULTS: The Prelingual group showed consistently lower CI thresholds than the Adult and Elderly groups during the postoperative 2-8 years, but no difference was detected between the Elderly and Adult groups, except at the postoperative 4 years. The elderly group's CI thresholds did not deteriorate until postoperative 8 years. The Prelingual group showed consistently larger T/C levels (minimum/maximum current strength from CI), especially C levels, than the other two groups. At the same time, there was no significant difference between the Elderly and Adult groups except for smaller dynamic ranges in the Elderly group until postoperative 2 years. These results in the CI programming parameters might explain the lower CI thresholds in the Prelingual group than in the other groups. Focusing on CI maps 1 and 3 years after implantation, the strength of the T/C levels was similar for all channels in the Prelingual group, but the Adult and Elderly groups showed larger electrical stimuli in channels responsible for the middle frequencies than those for the lower or higher frequencies.
CONCLUSIONS: Our results suggest a significant influence of prelingual deafness but less impact of elderly age at implantation on long-term CI programming parameters and CI thresholds. The larger C levels and lower CI thresholds in the Prelingual group than in the Adult and Elderly groups implied that CI children with prelingual deafness tolerate and prefer larger CI stimuli, which may reflect the CI-dependent development of their auditory system before the critical period. No age-related reduction in hearing thresholds was observed in the Elderly group, probably because the CI compensates for age-related dysfunction of the peripheral auditory system.
Rotator cuff tear is a common cause of pain and disability among adults. Most tears are largely caused by the normal wear and tear that goes along with aging. Although nonsurgical treatment relieves pain and improves function in the shoulder, surgical repair for a torn rotator cuff is indicated if symptoms persisted or deteriorated after 3 months nonsurgical treatments, Recently, arthroscopic repair has become the mainstream of surgical repair for rotator cuff tear. However, the healing of a repaired tendon is not always predictable. Mesenchymal stem cells (MSCs) are pluripotent cells that can differentiate into multiple mesenchymal tissues, including tenocytes, chondrocytes and osteoblasts, as well as being a source of multiple growth factors to establish an environment conducive to soft and hard tissue regeneration. As bone marrow concentration has high concentration of mesenchymal stem cells, some studies have shown that autologous bone marrow concentration can improve the healing of tendon grafts in a bone tunnel. Therefore, the goal of this study was to evaluate the effect of bone marrow concentration on healing of rotator cuff.
The food industry has been extremely successful in creating a broad range of delicious, affordable, convenient, and safe food and beverage products. However, many of these products are considered to be ultraprocessed foods (UPFs) that contain ingredients and are processed in a manner that may cause adverse health effects. This review article introduces the concept of UPFs and briefly discusses food products that fall into this category, including beverages, baked goods, snacks, confectionary, prepared meals, dressings, sauces, spreads, and processed meat and meat analogs. It then discusses correlations between consumption levels of UPFs and diet-related chronic diseases, such as obesity and diabetes. The different reasons for the proposed ability of UPFs to increase the risk of these chronic diseases are then critically assessed, including displacement of whole foods, high energy densities, missing phytochemicals, contamination with packaging chemicals, hyperpalatability, harmful additives, rapid ingestion and digestion, and toxic reaction products. Then, potential strategies to overcome the current problems with UPFs are presented, including reducing energy density, balancing nutritional profile, fortification, increasing satiety response, modulating mastication and digestion, reengineering food structure, and precision processing. The central argument is that it may be possible to reformulate and reengineer many UPFs to improve their healthiness and sustainability, although this still needs to be proved using rigorous scientific studies.