anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
It is now well recognized that the incidence of diabetes is increasing worldwide. It is the leading cause of end-stage renal disease (ESRD) in Western countries. Diabetic nephropathy has been reported to occur in 25%-40% of people with diabetes. The appearance of microalbuminuria usually is regarded as incipient nephropathy, but recently, work has suggested that some individuals with diabetes and decreased GFR may not have an increased urinary AER.Identification of markers for prediction of the clinical course of diabetic nephropathy remains a major challenge. Previous research showed that m/z14766 protein by mass spectrometry, was selectively excreted in the urine of diabetic nephropathy patients, the m/z 14766 mass peaks were identified as UbA52. We suppose that UbA52 can be regard as a simple and practical biomarker for diagnosis of diabetic nephropathy.
PURPOSE:To obtain a resin for denture base having improved thermal conductivity and mechanical characteristics, by blending a resin with whiskers and/or short fiber filler having high thermal conductivity. CONSTITUTION:A resin is blended with a filler (e.g. short fibers of metal or alloy, silicon nitride, silicon carbide or aluminum oxide) having high thermal conductivity to give a resin for denture base. Thermal conductivity of the resin increases with rise of amount of the filler added, mechanical strength is also increased but an excessive amount of the filler added loses surface smoothness of resin for denture base, enlarges water supply and makes the base brittle so that fixation of optimum amount added is required. By some combination of the filler and the resin, since the resin has insufficient wetting properties as it is, in that case, the surface of the filler is roughly processed or is treated with a surface treating agent. By using the above-mentioned resin, a denture base capable of feeling heat of drink and food can be produced.
The medicinally active component of Lithospermum erythrorhizon is obtained by extracting under substantially acidic conditions with a chlorohydrocarbon which is nearly or completely incombustible and heavier than water, covering the solvent with an aqueous layer, making the aqueous layer alkaline by addition of alkali hydroxide to transfer the medicinally active component to the aqueous layer and separating the layers.  Carbontetrachloride, chloroform or trichloroethylene may be used-in the commercial forms both carbontetrachloride and chloroform are slightly acid and further acid need not be added.  The organic solvent layer after separation may be acidified e.g. with hydrochloric, sulphuric or phosphoric acid, and further extracted.  The active component may be precipitated from the aqueous layer by addition of acid (HCl) and separated by centrifuging or filtration.  Any active material remaining in the aqueous layer may be extracted with ether: if desired the precipitate may be dissolved in the ethereal extract and the solution evaporated to give a homogeneous product.
OBJECTIVE: To investigate the predictive value of intraoperative bulbocavernosus reflex (BCR) monitoring for voiding dysfunction post-operatively in patients with distal intraspinal tumors and to determine an appropriate timing for postoperative follow-up assessment.
METHODS: Patients with distal intraspinal tumors who underwent surgery with BCR monitoring were collected. Patients were classified into BCR absent and present groups according to the monitoring responses at the end of surgery. Voiding function was evaluated at 1 week, 2 months, 4 months, and 6 months after surgery.
RESULTS: A total of 52 patients were included. There were 30 (57.7 %) males and the mean age was (48.6 ± 17.2) years. Forty-nine (94.2 %) patients were adult. BCR was preserved in 50 (96.2 %) patients and completely disappeared in 2 cases at the end of the surgery. The sensitivity of intraoperative BCR loss for worsened voiding were 20.0 %, 33.3 %, 66.7 %, and 100.0 % at 1 week, 2 months, 4 months, and 6 months post-operatively respectively. The specificity was all 100.0 % at the four follow-ups. Preoperative voiding difficulty was more common in patients suffering from worsened voiding than those maintained at 1 week post-operatively (P < 0.05).
CONCLUSIONS: Intraoperative BCR monitoring is a reliable technique to predict the postoperative voiding dysfunction in patients with distal intraspinal tumors. Preservation of the BCR is a robust indication for favorable postoperative urinary function as time goes on and 6-month post-operatively may be an optimal timing for functional assessment with high sensitivity and specificity. Preoperative voiding symptoms may be a risk factor for voiding difficulty at early stage after surgery.
PURPOSE:To facilitate the processing of chicken's egg and reduce the production cost of vaccine and processed egg food, by dissolving a part of an eggshell with an acid, thereby partially exposing eggshell membrane. CONSTITUTION:A hole is opened in an eggshell by the partial dissolution of the shell. The dissolution of the eggshell is carried out either by dipping an end of an egg in an acid liquid for a definite period to effect slow dissolution of the shell or by using an acid-resistant grinding material such as brush soaked with an acid liquid, pressing the brush toward the shell and rotating at a high speed to effect quick dissolution of the shell. The acid is e.g. hydrochloric acid, nitric acid, sulfuric acid, etc. The partial dissolution of the shell can be carried out at an arbitrary rate and the size of the opened hole can be freely adjusted according to the purpose.
Participants will receive a single oral dose of the combination of BIC plus FTC plus TAF tablet on Day 1. Multiple oral doses of JNJ-56136379 once daily on Day 6 to Day 24. A single oral dose of the combination of BIC plus FTC plus TAF tablet on Day 20.
Aging is associated with a priming of microglia such that they are hypersensitive to further immune challenges. As such high-fat diet during aging can have detrimental effects on cognition that is not seen in the young. However, conflicting findings also suggest that obesity may protect against cognitive decline during aging. Given this uncertainty we aimed here to examine the role of microglia in high-fat, high-sucrose diet (HFSD)-induced changes in cognitive performance in the aging brain. We hypothesised that 8 weeks of HFSD-feeding would alter microglia and the inflammatory milieu in aging and worsen aging-related cognitive deficits in a microglia-dependent manner. We found that both aging and HFSD reduced hippocampal neuron numbers and open field exploration; they also impaired recognition memory. However, the aging-related deficits occurred in the absence of a pro-inflammatory response and the deficits in memory performance persisted after depletion of microglia in the Cx3cr1-Dtr knock-in rat. Our data suggest that mechanisms additional to the acute microglial contribution play a role in aging- and HFSD-associated memory dysfunction.
The invention relates to a method for releasing an aldehyde or ketone of formula (2) by allowing a hydrolase to act on a compound of formula (1). The compound of formula (1) is used as a flavor or fragrance precursor. In formula (1), each of R 1 , R 2  and R 3  independently represents a hydrogen atom, an alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, an alkenyl group which may have a substituent, an aryl group which may have a substituent, or an aralkyl group which may have a substituent. R 1  and R 2  or R 1  and R 3  may form a ring. Ar represents an aryl group which may have a substituent. In formula (2), R 1 , R 2  and R 3  have the same definitions as those in formula (1). R 1  and R 2  or R 1  and R 3  may form a ring:
A single-blind randomized controlled trial (RCT) will be conducted, by assessors blind to group allocation. Participants will be referred to the study from 'Maccabi Healthcare Services' by family physicians and geriatric physician of 'Maccabi Healthcare Services Central District'. The majority of TECH protocol training will take place in the participants' home as self-practice. The assessment and weekly group meetings will take place at clinics of Maccabi Healthcare Services in the Central District. A Helsinki approval (#2016009) has already been obtained. Participants will receive information regarding the study and if eligible will sign a consent form, undergo the screening and then the pre-intervention assessments. Then they will be randomly allocated into experimental or control group by a computer program (stratification of the severity of the cognitive decline according to the Montreal Cognitive Assessment (MoCA) scores of above or below 23 points). The experimental group participants will receive the TECH protocol, while participants in the control group will continue to receive standard care. Following the intervention a second assessment will be performed, as well as six-months follow-up assessment.
Study subjects wil be randomized to either the Pregabalin or Placebo group. There is a 5o ,50 chance of being in either group.
Participants will receive a "high insulin infusion" (Hi-Ins) prior to quantifying insulin resistance and endothelial function. This infusion will result in participants having insulin levels similar to patients with type 1 diabetes for five hours.
PURPOSE: An aromatic composition containing cypress essential oil is provided to treat memory loss and cognitive disorder. CONSTITUTION: An aromatic composition which enhances memory and prevents and treats Alzheimer's disease contains 0.01-100 wt% of cypress essential oil as an active ingredient. The aromatic composition further contains a carrier, excipient, diluents, filler, binder, wetting agent, lubricant, disintegrant, or surfactant. A cosmetic product contains the aromatic composition. The cosmetic composition is used in the form of a shampoo, rinse, perfume, lotion, cream, skin, cleanser, mousse, hair wax, or hair gel. An aromatic agent, ointment, and deodorant contain the aromatic composition.
PCT No. PCT/JP90/01600 Sec. 371 Date Jul. 17, 1991 Sec. 102(e) Date Jul. 17, 1991 PCT Filed Dec. 10, 1990 PCT Pub. No. WO91/09024 PCT Pub. Date Jun. 27, 1991.The present invention relates to quinazoline-3-alkanoic acid derivatives having both an inhibitory effect on platelet aggregation and a hindering effect on aldose reductase together, represented by a general formula [I]   <IMAGE> [wherein R is hydrogen or a protecting group for carboxyl group, R1 is a lower alkyl group, alkenyl group, alkinyl group, lower alkoxy group, lower alkylthio group, halogen, phenyl group (this phenyl group may be substituted by one to three of lower alkyls, lower alkoxys, halogens, trifluoromethyls, carboxyethylenes or ethoxycarbonylethylenes, naphthyl group, heterocycle (this heterocycle may be substituted by one to three of lower alkyls), cycloalkyl group or benzoyl group (this benzoyl group may be substituted by lower alkyl or halogen), R2 and R3 are identically or differently hydrogens, halogens, lower alkyl groups, lower alkoxy groups, aralkyl groups which may be substituted, nitro groups, imidazolyl groups, imidazolylmethyl groups or  <IMAGE>  (R4 and R5 indicate identically or differently hydrogens or lower alkyl groups, or connected with each other to make five- or six-membered heterocycles which may contain other hetero atom, X is carbonyl, thiocarbonyl or methylene group (this methylene group may be substituted by lower alkyl group), A is lower alkylene or lower alkenylene, and n indicates an integer of 1 to 3], their salts, their preparation processes and medicinal drugs containing them.
In an embodiment, the present disclosure pertains to a composition. In some embodiments, the composition includes a cross-linked network of cyclic macromolecules. In some embodiments, the cyclic macromolecules are covalently cross-linked to one another by a plurality of cross-linking agents. In some embodiments, at least some of the cross-linking agents are covalently functionalized with a plurality of functional groups. In some embodiments, the plurality of functional groups include a chain of at least three atoms that protrude out of the cross-linking agents. In some embodiments, the cross-linking agents and the functional groups form a polymer matrix, such as poly (β-amino ester). In some embodiments, the composition is in the form of particles. In another embodiment, the present disclosure pertains to a method of administering an active agent to a subject. In some embodiments, the method includes administering a composition of the present disclosure to the subject.
Patients who receive inpatient stroke rehabilitation at Istanbul Physical Medicine Rehabilitation Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, will be included in the study by the inclusion and exclusion criteria. Their informed consent will be received. Initially, clinical and demographic data of all patients will be noted. Participants who volunteered for the study will be separated into the acupuncture treatment group and the control group by simple random sampling. Both the acupuncture treatment group and the control group will be included in the conventional rehabilitation program 2 hours a day, 7 days a week, for 8 weeks. In addition the acupuncture treatment group will get acupuncture treatment which will be applied to Baihui (DU20), Yintang (EX-HN3) points and bilateral Tai Chong (LR3), Hegu (LI4) points for 4 weeks, twice a week. During the application, the feeling of De Qi will be taken and the application will take 20 minutes. Measurements; Hamilton Depression Rating Scales, Hamilton Anxiety Rating Scales, Pittsburg Sleep Quality Index, Barthel Index, and change in psychiatric drug use will be assessed at baseline (week 0), 4th and 8th week post-treatment. The adverse events observed during the study will be noted and the compliance of patients in each application will be questioned by visual analog scale.
A socially assistive robot will be programmed to instruct 10-14 yoga postures for a group of 20-25 older adults. The yoga session will also include meditation and centering exercises.
Subjects with history of recent subacute Traumatic Brain Injury (TBI) will receive a single IV injection, 370 megabecquerel (MBq) \[10 millicurie (mCi)\] of 18F-AV-1451 2 to 6 weeks following injury. They will return for a follow-up injection approximately 6 months following injury.
The goal of this clinical trial is to learn about burnout syndrome among healthcare workers in tertiary hospital. The main questions It aims to answer are what kind of music therapy used as a non-pharmacological intervention for health workers with Burnout Syndrome, Maslach Burnout Inventory and Heart Rate Variability score in health workers with Burnout Syndrome before and after music therapy, and does music therapy improve Maslach Burnout Inventory and Heart Rate Variability score in health workers with Burnout Syndrome. Participants will get examined using Maslach Burnout Inventory-Human Service Survey and Heart rate variability device before starting the music therapy. Music therapy will be conducted in two groups, one using 3 session a week for 4 weeks and the second group will get 5 session a week for 2 weeks. After all the session are done, participant will get their Maslach burnout inventory and heart rate variability score evaluate. Researchers will compare the results with neutral group without any music therapy to see if there are any positive effects of music therapy to Maslach burnout inventory and heart rate variability score.
Sleep deprivation is a common problem among older adults. It is often at the root of increased mortality and some psychiatric disorders. Regular participation in a medium-intensity exercise regimen may help people sleep better. This study will assess the effectiveness of a regular exercise program on improving sleep in older adults with moderate difficulty sleeping.

Participants will be randomly assigned to one of two conditions. One group will partake in a moderate-intensity physical activity training regimen. The other group will act as a non-exercise attention-control comparison group. Each group will undergo its assigned treatment for 12 months. Sleep quantity and quality will be measured objectively using in-home polysomnography. Subjective sleep quality and health-related quality of life measures will be evaluated with questionnaires. All measurements will be performed at the beginning of the study, Month 6, and Month 12.
Cyclic Hypobaric Hypoxia (CHH) subjects were given 40 min sessions inside the CVAC device per day (two 20 min sessions sequentially per day), 3 days a week for 10 weeks, for a total of 30 sessions or 20 hours. After familiarization sessions, pre-programmed sessions were administered, progressing from Tier 1 to 5. Subjects rotated through three pre-programmed sessions per Tier and each session varied the pattern and rate of hypoxic fluctuations, so that subjects would experience a constantly changing stimulus at each elevation. Five weeks were allotted to progress from Tier 1 (3048 m) to Tier 4 (5486 m). At Tier 5 (6096 m), there was an additional 5 weeks of exposure.
BACKGROUND: The anal symptoms occurring during pregnancy and post-partum, mainly related to Haemorrhoidal Disease (HD), have been reported with in a wide range of incidence in the literature. Although in many cases the course of the disease is mild and self-limiting, sometimes it is severe enough to affect quality of life.
METHODS: Our study has been conducted through a questionnaire administered via social media with the aim of obtaining epidemiologic data on the incidence of the symptoms of HD in an unselected population of pregnant women. In addition, we looked for the presence of those factors notoriously predisposing or associated to HD (constipation, straining on the toilet, low dietary fibres and fluid intake).
RESULTS: Out of 133 patients 51% reported symptoms of HD during pregnancy, mainly in the second and third trimester. Constipation, straining on the toilet, low dietary fibres and fluid intake were not significantly related to incidence of HD. Only a previous history of HD was correlated to onset of symptoms of HD in pregnancy and reached a statistical significance (odds ratio = 5.2, p < 0.001).
CONCLUSION: Although with the limitations posed by the nature of our retrospective study via a self-assessment interview, our results suggest that the occurrence of HD in pregnancy seems not sustained by the classical risk factors observed in the general population. At the moment, specific therapeutic measures are lacking and treatment relies on empiric suggestions concerning diet, fluid intake, bowel care, local ointment. Further studies are needed in order to identify a targeted etiologic treatment.
Methods for using bioadhesive and stearic interactions specific to copolymers with at least two moieties, to minimize adverse effects. These copolymers are useful for reducing rates of viral infectivity in target cells and in reducing host morbidity. These copolymers are useful for reducing a number of agents whose toxicity can manifest as a corneal epithelial toxicity. Methods for enhancing efficacy through coformulations with mucopenetration enhancing technologies and in coformulations with other actives that inhibit macropinocytosis increase efficacy in patient treatment approaches described herein. Coformulations with other actives ingredient will have therapeutic utility and prove beneficial in various settings. Formulations of these multifunctional copolymers for topical ophthalmic use are safe and well tolerated. Epithelial cells and the ocular surface including limbal stem cell and precursor corneal epithelial cells are treated with these copolymers to confer utility and patient benefit. Corneal nerves are similarly protected and corneal nerve cell damage is mitigated.
The intervention is based on the principles of the teaching of the ancient Greek philosopher Pythagoras. These principals set a basic framework for behavior on the basis of experiential learning and weekly evaluation of the implementation of 12 virtues. The technique is practiced twice a day(before night sleep and in the morning before getting up from bed) and evolves into five successive steps;1)reading of the 12 virtues and diaphragmatic breathing, 2)recall every event og the day,3)third person visualization and self-observation, 4)self-dialogue "What have I done wrong?", "What have I done right?", "What have I omitted that I ought to have done?" Endorsement or disapproval of actions according to the 12 virtues and the instructions for a healthy lifestyle, 5) next morning brief revision of the previous night's conclusions and setting of goals for the upcoming day.
The present invention includes a method for detecting and translating uncoordinated, mixed linguistic, coded, and symbolic anatomic site data into coordinates, axes, visualizations, maps, avatars, record results, and sequenced data. The mixed inputs may be text terms or verbal inputs in any linguistic language, or coded inputs such as ICD-11 codes for anatomy, or numerical codes corresponding to an anatomic site, region or other descriptive term, or symbolic inputs such as emojis. In an exemplar of symbolic code, a "nose" emoji categorizes nasal sites. The mixed inputs are automatically detected, categorized, and organized into fully sequenced translations, including synonyms, and into visualizations, records, and coordinates relative to anatomic sites. Linguistic inputs that are categorized can include identifiers, lateralities, prefixes, suffixes, anatomic site names, categories, modifier terms such as directional modifiers, custom descriptors, anatomic distributions, distribution segments, and synonyms for each of the preceding inputs. The present invention delivers language translations in a natural linguistic sequence for the language, with corresponding visualizations, including anatomic maps and avatars which themselves can include multidimensional, custom axes defined coordinate systems, and records related to a patient that have anatomic descriptions or images associated with them. The delivered anatomic maps and avatars can be overlaid or underlaid and aligned to other images that contain anatomy. Additionally, this invention includes progressive sub¬ segmentation of the mixed inputs to deliver human readable, accurate, and precise descriptions with corresponding visualizations and coordinates up to a pinpoint level, as well as coded descriptions. Finally, the present invention includes axial mirroring to display the mixed-input- derived visualizations and anatomic maps, to show and interact with the visualizations and maps in both outside-observer view and in selfie-view.
INTRODUCTION: Postoperative urinary dysfunction poses a significant challenge for rectal cancer patients. While pelvic floor muscle training (PFMT) has shown promise in other contexts, its efficacy following rectal cancer surgery remains uncertain.
RESULTS: A clinical trial involving 79 rectal cancer patients found that initiating Kegel exercises post-surgery led to significant improvements in urinary symptoms compared to standard care. Adherence to exercises correlated with symptom reduction, with no reported adverse events. We have defined the main outcome of our study as the improvement in urinary function scores post-surgery. Effectiveness is considered as any statistically significant improvement in these scores.
CONCLUSION: Early initiation of Kegel exercises shows promise in alleviating postoperative urinary dysfunction in rectal cancer patients. Further research is needed to optimize postoperative care protocols and enhance patient outcomes.