anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIMS: Participants with cardiovascular diseases (CVD) often exhibit liver function abnormalities, hepatic fibrosis and cirrhosis. The extent of liver fibrosis is closely related to the prognosis of CVD. However, the association between the liver fibrosis-8 (FIB-8) index, a marker of liver fibrosis, and all-cause mortality in CVD participants remains unclear. This study aims to investigate the relationship between the FIB-8 index and all-cause mortality among individuals with CVD.
MATERIALS AND METHODS: A total of 1727 CVD American participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. Initially, we constructed weighted COX regression models and performed sensitivity analyses to examine the correlation between the FIB-8 index and all-cause mortality in CVD participants. Subsequently, we employed restricted cubic spline (RCS) to visualize their linear relationship. Finally, the stratified analyses and interaction tests of covariates were performed and presented in the forest plot.
RESULTS: A total of 1727 participants were included in our study, with a mean age of 61.68 ± 0.47 years, with men accounting for 59.19%. After adjustment for relevant covariables, weighted COX regression models indicated that the hazard ratio (HR) and 95% confidence interval (95% CI) for the association between the FIB-8 index and all-cause mortality in CVD participants was 1.21 (1.12, 1.30). Sensitivity analysis was then conducted, revealing that the results remained stable. In fully adjusted model, individuals in quartiles 3 and 4 demonstrated significant statistical differences compared to the lowest FIB-8 index quartile, with HR (95% CI) values of 1.88 (1.23, 2.87) and 2.17 (1.33, 3.53), respectively. Subsequently, RCS showed a linear relationship between the FIB-8 index and all-cause mortality among CVD participants. Finally, the interaction test revealed that no other covariables had significant interactions with the FIB-8 index in this study.
CONCLUSIONS: A positive and linear correlation was observed between the FIB-8 index and all-cause mortality among CVD adult participants in NHANES from 1999 to 2018. Our findings indicated that the FIB-8 index could serve as an excellent indicator for assessing all-cause mortality within the CVD population. The lower the FIB-8 index, the lower the all-cause mortality among CVD participants.
PURPOSE: To obtain a wrinkling suppression agent effective for preventing the aging of skin, especially preventing the formation of wrinkles by using a plant of the genus Cyperus or its extract as an active component. CONSTITUTION: This wrinkling suppression agent contains a plant of the genus Cyperus (e.g. umbrella sedge, Cyperus brevifolius and flatstage) or its extract as an active component in an amount of usually 0.001-20wt.%, preferably 0.001-3wt.% in terms of solid. The wrinkling suppression effect can be improved by adding an anti-inflammatory agent (e.g. allantoin), an antioxidant (e.g. α-tocopherol), etc. It can be prepared in the form of conventional cosmetics such as ointment, O/W-type or W/O-type emulsified cosmetic, cream, cosmetic milky lotion, face lotion, oily cosmetic, pack and foundation by properly adding conventional cosmetic components.  The extract is produced by extracting the whole grass or its leaf, stalk, root, fruit, seed and/or flower of a plant of the genus Cyperus or its dried and pulverized product with a solvent (e.g. ethanol) at room temperature or under heating.
BACKGROUND: The standard treatment for advanced esophageal cancer with synchronous distant metastasis is systemic chemotherapy or immunotherapy. Conversion surgery is not established for esophageal cancer with synchronous distant metastasis. This study aimed to investigate the clinical impact of conversion surgery for esophageal cancer with synchronous distant metastasis after induction therapy.
METHODS: This multi-institutional retrospective study enrolled 66 patients with advanced esophageal cancer, including synchronous distant metastasis, who underwent induction chemotherapy or chemoradiotherapy followed by conversion surgery between 2005 and 2021. Short- and long-term outcomes were investigated.
RESULTS: Distant lymph node (LN) metastasis occurred in 51 patients (77%). Distant organ metastasis occurred in 15 (23%) patients. There were 41 patients with metastatic para-aortic LNs, and 10 patients with other metastatic LNs. Organs with distant metastasis included the lung in seven patients, liver in seven patients, and liver and lung in one patient. For 61 patients (92%), R0 resection was achieved. The postoperative complication rate was 47%. The in-hospital mortality rate was 1%, and the 3- and 5-year overall survival (OS) rates for all the patients were 32.4% and 24.4%, respectively. The OS rates were similar between the patients with distant LN metastasis and the patients with distant organ metastasis (3-year OS: 34.9% vs. 26.7%; P = 0.435). Multivariate analysis showed that pathologic nodal status is independently associated with a poor prognosis (hazard ratio, 2.43; P = 0.005).
CONCLUSIONS: Conversion surgery after chemotherapy or chemoradiotherapy for esophageal cancer with synchronous distant metastasis is feasible and promising. It might be effective for improving the long-term prognosis for patients with controlled nodal status.
To find and provide at least initial treatments after the infection with the Novel Coronavirus.SOLUTION: According to "Concept of order of resistance of various pathogens to disinfection" of the US CDC (Centers for Disease Control and Prevention), a fungus {e.g., mold, ringworm, yeast, and the like} has an antibacterial function against fungi because of being more resistant to disinfection than the Novel Coronavirus. Eutrema japonicum and the like also have an antiviral function against it (there are multiple supporting papers) and are safe foods. The inventor carefully applied the kneaded product of Eutrema japonicum in a tube to the foot with Trichophyton fungus and confirmed healing. The inventor has the experience that "food poisoning is cured by eating Eutrema japonicum, and stuffy nose and thick mucous nasal discharge in sinusitis, which had no surgical effect, are eliminated by sterilization and disinfection of the nose with a thick solution of Eutrema japonicum that was repeated almost every day." A gas (such as allyl isothiocyanate) generated from the paste of Eutrema japonicum can be used to disinfect the inside of the nose. Using this method several times heals nasal cold immediately after onset. Please confirm the demonstration by each expert! Free release of this application.SELECTED DRAWING: Figure 1
EOIPB will be administered by a single anesthetists following the intubation. A linear ultrasound transducer is positioned in the sagittal plane at the 6th rib level, between the anterior axillary and midclavicular lines. The ribs, lungs, pleura, intercostal muscles, external oblique muscle and subcutaneous tissue are visualized in the image. The in-plane technique with a 22G, 80 mm block needle is used to inject 30 ml of 0.25% bupivacaine into the external oblique intercostal plane on both sides.
BACKGROUND: Inflammation and disruption of cardiac metabolism are prevalent in the setting of myocardial ischemia. Canagliflozin, a sodium-glucose costransporter-2 inhibitor, has beneficial effects on the heart, though the precise mechanisms are unknown. This study investigated the effects of canagliflozin therapy on metabolic pathways and inflammation in ischemic myocardial tissue using a swine model of chronic myocardial ischemia.
METHODS: Sixteen Yorkshire swine underwent placement of an ameroid constrictor to the left circumflex artery to induce chronic ischemia. Two weeks later, pigs received either no drug (n = 8) or 300 mg canagliflozin (n = 8) daily. Five weeks later, pigs underwent terminal harvest and tissue collection.
RESULTS: Canagliflozin treatment was associated with a trend toward decreased expression of fatty acid oxidation inhibitor acetyl-CoA carboxylase and decreased phosphorylated/inactivated acetyl-CoA carboxylase, a promotor of fatty acid oxidation, compared with control ischemic myocardium (P = .08, P = .03). There was also a significant modulation in insulin resistance markers p-IRS1, p-PKCα, and phosphoinositide 3-kinase in ischemic myocardium of the canagliflozin group compared with the control group (all P < .05). Canagliflozin treatment was associated with a significant increase in inflammatory markers interleukin 6, interleukin 17, interferon-gamma, and inducible nitric oxide synthase (all P < .05). There was a trend toward decreased expression of the anti-inflammatory cytokines interleukin 10 (P = .16) and interleukin 4 (P = .31) with canagliflozin treatment.
CONCLUSION: The beneficial effects of canagliflozin therapy appear to be associated with inhibition of fatty acid oxidation and enhancement of insulin signaling in ischemic myocardium. Interestingly, canagliflozin appears to increase the levels of several inflammatory markers, but further studies are required to better understand how canagliflozin modulates inflammatory signaling pathways.
Pharmaceutical compositions comprising Scutellaria having antiviral activity against Coronavirus, particularly against Severe Acute Respiratory Syndrome (SARS). Preferably, the Scutellaria spp is selected from S. baicalensis , S. amoena, S. barbata, S. discolour, S. hypericifolia, S. inbica, S. likiangensis, S. orthocalyx, S. rehderiana, S. scssiliflora and S. viscidula. The Scutellaria may be a botanical raw material, botanical drug substance or botanical ingredient. Preferably, the extract is standardised and is an ethanolic and/or lyophilised extract. In another aspect, extracts of one or more of Scutellaria, Lonicera, Forsythia, Rabdosia for the treatment of SARS. In another aspect, the use of one or more of baicalin, baicalein, chlorogenic acid, forsythiaside, caffeic acid and phillyrin for the treatment of SARS.
The estrus cycle in female rodents has been shown to affect a variety of physiological functions. However, little is known about its presumably thorough effect on auditory processing during the sleep-wake cycle and sleep deprivation. Vertex auditory evoked potentials (vAEPs) were evoked by single click tone stimulation and recorded during different stages of the estrus cycle and sleep deprivation performed in metestrus and proestrus in female rats. vAEPs showed a strong sleep-dependency, with the largest amplitudes present during slow wave sleep while the smallest ones during wakefulness. Higher amplitudes and longer latencies were seen in the light phase during all vigilance stages. The largest amplitudes were found during proestrus (light phase) while the shortest latencies were seen during estrus (dark phase) compared to the 2nd day diestrus baseline. High-amplitude responses without latency changes were also seen during metestrus with increased homeostatic sleep drive. More intense and faster processing of auditory information during proestrus and estrus suggesting a more effective perception of relevant environmental cues presumably in preparation for sexual receptivity. A 4-h sleep deprivation resulted in more pronounced sleep recovery in metestrus compared to proestrus without difference in delta power replacement suggesting a better tolerance of sleep deprivation in proestrus. Sleep deprivation decreased neuronal excitability and responsiveness in a similar manner both during metestrus and proestrus, suggesting that the negative consequences of sleep deprivation on auditory processing may have a limited correlation with the estrus cycle stage.
Although Hepatitis C virus (HCV) infection can be cured with direct-acting antivirals (DAA), some cured patients face a serious risk of advanced liver damage and early mortality. In order to avoid these two negative health outcomes, it is important to identify and assess related risk factors. Little is currently known about socioeconomic and behavioural factors in this context. Using data from the ANRS CO22 Hepather cohort, we tested for associations between socioeconomic and behavioural factors and (i) advanced liver fibrosis (defined as an FIB-4 > 3.25) assessed longitudinally using a mixed-effects logistic regression model (both the whole population and stratified on advanced liver fibrosis status at the time of HCV cure) and (ii) all-cause mortality (Cox proportional hazards model), during post-HCV cure follow-up. Among 5833 participants cured of HCV, living in poverty was associated with postcure advanced liver fibrosis in participants without this diagnosis at the time of HCV cure (population attributable fraction-PAF-of 8.6%) and with mortality in the whole study population (PAF of 10.6%). The detrimental effects of unhealthy alcohol use and heavy tobacco smoking, as well as the beneficial effect of living with a stable partner were also highlighted. We highlighted the major role of poverty and behavioural factors in advanced liver fibrosis and all-cause mortality in patients cured of HCV. Encouraging linkage to social support services and healthy behaviours after successful DAA treatment could limit morbidity and increase survival in this population. Clinical Trial Registration: ClinicalTrials.gov: NCT01953458.
BACKGROUND: Radiotherapy is a critical treatment modality for nasopharyngeal carcinoma (NPC). However, the mechanisms underlying radiation resistance and tumour recurrence in NPC remain incompletely understood.
METHODS: Oxidised lipids were assessed through targeted metabolomics. Ferroptosis levels were evaluated using cell viability, clonogenic survival, lipid peroxidation, and transmission electron microscopy. We investigated the biological functions of glutathione S-transferase mu 3 (GSTM3) in cell lines and xenograft tumours. Co-immunoprecipitation, mass spectrometry, and immunofluorescence were conducted to explore the molecular mechanisms involving GSTM3. Immunohistochemistry was performed to investigate the clinical characteristics of GSTM3.
RESULTS: Ionising radiation (IR) promoted lipid peroxidation and induced ferroptosis in NPC cells. GSTM3 was upregulated following IR exposure and correlated with IR-induced ferroptosis, enhancing NPC radiosensitivity in vitro and in vivo. Mechanistically, GSTM3 stabilised ubiquitin-specific peptidase 14 (USP14), thereby inhibiting the ubiquitination and subsequent degradation of fatty acid synthase (FASN). Additionally, GSTM3 interacted with glutathione peroxidase 4 (GPX4) and suppressed GPX4 expression. Combining IR treatment with ferroptosis inducers synergistically improved NPC radiosensitivity and suppressed tumour growth. Notably, a decrease in GSTM3 abundance predicted tumour relapse and poor prognosis.
CONCLUSIONS: Our findings elucidate the pivotal role of GSTM3 in IR-induced ferroptosis, offering strategies for the treatment of radiation-resistant or recurrent NPC.
Dosing Regimen 3 (Q12W) is not used until Week 12. At Week 12, participants who were re-randomized to this arm were administered one 80-mg SC injection Q12W.
BACKGROUND: Robotic cholecystectomy is being increasingly used for patients with acute gallbladder disease who present to the emergency department, but clinical evidence is limited. We aimed to compare the outcomes of emergent laparoscopic and robotic cholecystectomies in a large real-world database.
METHODS: Patients who received emergent laparoscopic or robotic cholecystectomies from 2020 to 2022 were identified from the Intuitive Custom Hospital Analytics database, based on deidentified extraction of electronic health record data from US hospitals. Conversion to open or subtotal cholecystectomy and complications were defined using ICD10 and/or CPT codes. Multivariate logistic regression with inverse probability treatment weighting (IPTW) was performed to compare clinical outcomes of laparoscopic versus robotic approach after balancing covariates. Cost analysis was performed with activity-based costing and adjustment for inflation.
RESULTS: Of 26,786 laparoscopic and 3,151 robotic emergent cholecystectomy patients being included, 64% were female, 60% were ≥45 years, and 24% were obese. Approximately 5.5% patients presented with pancreatitis, and 4% each presenting with sepsis and biliary obstruction. After IPTW, distributions of all baseline covariates were balanced. Robotic cholecystectomy decreased odds of conversion to open (odds ratio, 0.68; 95% confidence interval, 0.49-0.93; p = 0.035), but increased odds of subtotal cholecystectomy (odds ratio, 1.64; 95% confidence interval, 1.03-2.60; p = 0.037). Surgical site infection, readmission, length of stay, hospital acquired conditions, bile duct injury or leak, and hospital mortality were similar in both groups. There was no significant difference in hospital cost.
CONCLUSION: Robotic cholecystectomy has reduced odds of conversion to open and comparable complications, but increased odds of subtotal cholecystectomy compared with laparoscopic cholecystectomy for acute gallbladder diseases. Further work is required to assess the long-term implications of these differences.
LEVEL OF EVIDENCE: Therapeutic/Care Management; Level IV.
1524447 Phytosterol compositions GENERAL MILLS CHEMICALS INC 4 June 1976 [6 June 1975] 23287/76 Heading A5B [Also in Division C5] Compositions comprising a blend of a phytosterol (i.e. a sterol obtained from a plant source, such as stigmasterol, campesterol, sitosterol and/or brassicasterol or the naturally occurring esters thereof) and a free saturated fatty acid and/or fatty alcohol having an even numbered C 12-18  carbon chain (e.g. lauric, myristic, palmitic or stearic acid, lauryl, myristyl, cetyl or stearyl alcohol), the said blend being substantially free of triglyceride, are prepared by heating the fatty acid and/or fatty alcohol to a molten condition and dispersing the phytosterol, preferably also heated to melting, therein. The compositions may be used in cosmetic compositions e.g. as emulsions with triethanolamine or liquid paraffin, or as shampoos comprising e.g. aqueous sodium lauryl sulphate, triethanolamine lauryl sulphate and lauric and myrisfic diethanolamides.
PURPOSE: A composition containing cattlefish fraction dry powder or extract is provided to reduce total cholesterol in blood and to prevent and treat arteriosclerosis. CONSTITUTION: A pharmaceutical composition for preventing and treating arteriosclerosis contains cattlefish fraction dry powder or extract as an active ingredient. The cattlefish is fractioned in cattelfish body, meat, liver, bone, head, legs, skin, or eye. The cattelfish fraction extract is isolated using water, low alcohol of 1-4 carbon atoms, or mixture solvent thereof. A health food for preventing and treating arteriosclerosis contains cattlefish fraction dry powder or extract as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, or beverage.
PURPOSE: This study aimed to characterize the histopathological immunohistochemical features of chronic sclerosing sialadenitis, emphasizing the IgG4-related disease.
METHODS: Seventeen cases of chronic sclerosing sialoadenitis were examined for histopathological aspects, (inflammation, fibrosis, glandular parenchyma, and lymphoid follicles) and immunohistochemistry (BCL2, CD3, CD20, CD34, CD163, p63, cyclin D1, mast cell, SMA, S100A4, IgG, and IgG4) which were scored. IgG4-related disease features were investigated. Demographic and clinical data were also collected.
RESULTS: Males predominated (10:7), with an average lesion size of 3.9 cm. Common histopathological findings included reduced acinar parenchyma, lymphoid follicle formation, and ductular proliferation. CD3-positive T lymphocytes and CD34- and SMA-positive stromal fibroblasts were abundant. Nine cases (53%) showed sialoliths and three cases met the criteria for IgG4-related disease.
CONCLUSION: CSS of the submandibular gland represents a reactive pattern rather than IgG4-RD as only 3 cases seemed to be related to IgG4-RD. The immunohistochemical profile revealed an abundant population of CD3-positive T lymphocytes, as opposed to regulatory proteins such as cyclin D1, demonstrating that populations of CD34- and SMA-positive stromal fibroblasts contribute to the fibrosis characteristic of CSS. In addition, our results provide a comprehensive insight into the study of CSS and its relationship with IgG4-RD.
NEW MATERIAL:A perfluoro compound of formulaI(RF is perfluoroalkyl, perfluoroalkoxyalkyl or perfluoroalkyloxy; X and X' are F atom or perfluoroalkyl; Y is perfluoroalkyloxy or perfluorodialkylamino group having total 8-11 carbon atoms). EXAMPLE:Perfluoro-3-n-propoxy-2-methylpentane. USE:Useful as a synthetic blood substitute or infusion medium. PROCESS:A partially fluorinated compound of formula II (RF1' is partially fluorinated alkyl, alkyloxy, alkyloxyperfluoroalkenyl, etc.; X1 and X2 are H, F, etc.) is reacted with only molecular fluorine in an inert solvent at -75-+100 deg.C while keeping the molecular fluorine stoichiometrically excess in the reaction to give the compound of formulaI.
PURPOSE: To obtain a cosmetic containing an aqueous polymer emulsion, having excellent water resistance, gloss and film-forming property. CONSTITUTION: This cosmetic contains 1-60wt.% (in terms of solid content) aqueous polymer emulsion obtained by copolymerizing a cycloalkyl group- containing monomer (e.g. cyclohexyl acrylate) having polymerizable double bond with a monomer (e.g. styrene) having double bond copolymerizable with the monomer in the presence of a plasticizer or film-forming auxiliary. The blend amount of the cycloalkyl group-containing monomer is 0.1-98wt.% based on total constitutional monomer in the aqueous polymer emulsion and the blend amount of the plasticizer and the film-forming auxiliary is 1-50 pts.wt. based on 100 pts.wt. of the above monomer.  The cosmetic is applied to skin and hair and strong to perspiration and water and free from messy makeup and excellent in non-stickiness, quick dryness, high film hardness, water resistance, adhesion, abrasion resistance, etc., especially when used for nail enamel, etc.
A system for alterting heathcare practitioners (20) includes a plurality of receiving devices (10), and a sending station (30). Each of the plurality of receiving device is associated with a corresponding healthcare practitioner. The receiving device (10) includes a user alerting device (120), a receiver (110), and circuitry (160). The user alerting device (120) alerts the practitioner to a received message with one of a plurality of types of alerts. The receiver (110) receives the incoming messages. The circuitry (160) causes the user alerting device to alert the practitioner to an incoming message with one of the plurality of types of alerts. The sending station (30) sends the messages carrying healthcare information of one of a plurality of preselected types of healthcare significants to a selected one or more of the receiving devices, each message corresponding to a selected one of the types of alerts, such that the receiving device alerts the practitioner to receiving the message with the selected type of alerts.