anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
All consecutive patients with complex coronary artery disease (CAD) were treated with percutaneous coronary intervention (PCI). The complexity of CAD was defined as having at least one of the following characteristics: chronic total occlusion (CTO), lesion length \>40 mm, severe calcification assessed by angiography or intravascular imaging examination, multivessel PCI during the same intervention, or true bifurcation defined as any lesion involving both the main vessel (MV), proximal or distal and the ostium of the side branch (SB) (Medina 1,1,1; 1,0,1; or 0,1,1).
NEW MATERIAL:A compound of the formula (Z is halogen; Ma and Mb are alkoxycarbonyl group; m is a positive number). EXAMPLE:Diethyl(gamma-trichlorosilyl)propylmalonate. USE:A raw material compound for polysilsesquioxane which is a carcinostatic agent. PREPARATION:A trihalogenosilane, e.g. trichlorosilane, is added to an alkylmalonic acid derivative having a terminal double bond e.g. diethyl allylmalonate, in the presence of a catalyst, e.g. a platinum compound, e.g. chloroplatinic acid hexahydrate, by the so-called hydrosilylation reaction.
Patients with ESBL, antibiotic pressure will be included. On the day of inclusion, a stool culture is performed on the first stool issued after the start of antibiotic therapy in order to evaluate the initial flora and the relative initial faecal abundance of multidrug-resistant bacteria. In the absence of stool emission by the patient, a rectal swab will be performed. 72 hours after initiation of antibiotic therapy, a blood sample (5 ml) will be taken to determine plasma concentrations of antibiotics. In addition, a stool sample will be taken at 72 hours after the start of antibiotic therapy, at the end of antibiotic therapy and 60 days after this end to evaluate the change in initial flora and relative faecal abundance of ESBL-producing enterobacteria.
Ferroptosis, a key factor in tumor progression, is poorly understood at the molecular level. This study investigates how ELK4 and CHMP6 regulate skin cutaneous melanoma (SKCM) cell proliferation and ferroptosis. Analysis of TCGA data reveals high expression of ELK4 and CHMP6 in SKCM. Overexpression of ELK4 or CHMP6 enhances cell proliferation, invasion, and migration while reducing ROS and Fe2 + levels. It also increases GPX4 and xCT expression and decreases ACSL4 levels in SKCM cells. The opposite effects are observed with ELK4 or CHMP6 knockdown. ELK4 binds to the CHMP6 promoter, promoting CHMP6 transcription. Knockdown of CHMP6 reverses the oncogenic effects of ELK4 overexpression. In conclusion, ELK4 enhances proliferation, invasion, and migration while inhibiting ferroptosis in SKCM cells by upregulating CHMP6 transcription. This study sheds light on the intricate mechanisms involved in SKCM progression and identifies potential therapeutic targets in melanoma treatment.
BACKGROUND: Recurrent anterior shoulder instability remains the most common complication from a prior shoulder dislocation, especially among young and active individuals who engage in athletic activities. This instability can lead to repeated subluxation or dislocations of the humeral head from the glenoid fossa. The purpose of this study is to compare postoperative recurrence rates, instability-related revision and return to sport (RTS) rates between isolated arthroscopic Bankart repair (ABR) and ABR with remplissage (ABR + R) for anterior shoulder instability with subcritical glenoid bone loss (GBL) and a Hill-Sachs lesion (HSL).
METHODS: PubMed, Embase, and Web of Science were searched on June 2022. Studies sought were those comparing postoperative outcomes of ABR + R versus isolated ABR for subcritical GBL and an HSL. Study quality was evaluated using the revised Cochrane tool. Redislocations, instability-related revisions, and RTS rates were extracted and pooled estimates were calculated using the random-effect model.
RESULTS: Twelve studies were included with a mean follow-up of 48.2 months for isolated ABR and 43.2 months for ABR + R. The meta-analytic comparison demonstrated that ABR + R resulted in statistically significant improvement in Rowe and American Shoulder and Elbow Surgeons scores by 6.5 and 2.2 points, respectively; however, the improvements in patient-reported outcomes were not clinically meaningful. ABR + R resulted in reduced external rotation at the side by 1° which was not clinically meaningful and there was no significant difference in terms of forward elevation. ABR + R resulted in a statistically significant reduction of overall postoperative recurrences (odds ratio [OR]: 9.36), postoperative dislocations (OR: 6.28), instability-related revision (OR: 3.46), and RTS to any level (OR: 2.85).
CONCLUSION: The addition of remplissage to ABR for recurrent anterior shoulder instability with subcritical GBL and HSL results in significantly lower postoperative instability recurrence, lower instability-related revisions, and higher RTS to any level.
Xeroderma Pigmentosum (XP) is a rare, recessive disorder with a more than 1000-fold increase in the frequency of all major skin cancers in association with defective DNA repair. The risk of skin and other cancers among normal appearing XP heterozygote individuals has not been fully studied. We plan to study the family members from XP families with known DNA repair gene mutations to determine if heterozygote carriers of XP disease mutations are at an increased risk of developing cancer. For controls we will compare XP heterozygotes to their non-carrier blood relatives and spouses and to the Surveillance, Epidemiology and End Results (SEER) rates. For this purpose, blood, skin or buccal cells will be obtained from all available relatives for DNA or RNA mutation analysis. Cancer confirmation will be accomplished through review of pathology reports, medical records and death certificates. In addition, willing family members will be clinically examined to determine current cancer status. Individuals who are determined to be heterozygous carriers of XP DNA repair gene disease mutations in these families by mutation analysis or by pedigree will be compared to non-carrier relatives and spouses with respect to history of any type of cancer. We will also focus on skin cancer and cancer of the nervous system since the risks of these cancers are elevated among the XP homozygotes.
NEW MATERIAL:The compound of formula I (X is acid residue; R<2> is alkanoyloxy, carbamoyloxy or heterocyclic-thio group which may have proper substituent group; R<3> is protected carboxy). EXAMPLE:7-( 2-Hydroxyimino-3-oxo-4-bromobutylamido )-3-( 1-methyl-1H-tetrazol- 5-yl)thiomethyl-3-cephem-4-carboxylic acid diphenylmethyl ester. USE:Useful as a raw material for the preparation of antibacterial agent. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II with a nitrosation agent such as nitrous acid, etc. in a solvent such as benzene under cooling or at room temperature. The starting compound of formula II is novel compound.
TQ05105 Tablets combined with TQB3909 Tablets, orally administered. 28 days as a treatment cycle.
HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left ventrolateral prefrontal cortex (VLPFC; x=-50, y=+26, z=+8) and posterior cingulate cortex (PCC; x=1, y=-61, z=38) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes.
Pelvic RT is delivered using IMRT technique, 45～50.4 Gy/4～7 weeks, brachytherapy will been given as necessary. Cisplatin 35 mg/m(2) IV once a week. Total treatment time is 6-7 weeks.
Treatment of Overdosage: Basic life support measures should be instituted as dictated by the clinical presentation of the carisoprodol overdose. Vomiting should not be induced because of the risk of CNS and respiratory depression, and subsequent aspiration. Circulatory support should be administered with volume infusion and vasopressor agents if needed. Seizures should be treated with intravenous benzodiazepines and the reoccurrence of seizures may be treated with phenobarbital. In cases of severe CNS depression, airway protective reflexes may be compromised and tracheal intubation should be considered for airway protection and respiratory support. 

For decontamination in cases of severe toxicity, activated charcoal should be considered in a hospital setting in patients with large overdoses who present early and are not demonstrating CNS depression and can protect their airway.

For more information on the management of an overdose of carisoprodol, contact a Poison Control Center.
OBJECTIVE: The current study aims to evaluate the correlation between oxytocin augmentation and postpartum hemorrhage.
METHOD: PubMed, Web of Science, and Scopus has been searched for studies assessing the correlation between oxytocin augmentation and postpartum hemorrhage up to January 24, 2024. The search strategy included relevant keywords related to PPH and oxytocin augmentation. The risk of bias assessment was conducted by two reviewers using the Newcastle-Ottawa Scale (NOS). To pool the effects sized of included studies odds ratios (OR) of interest outcome with their 95% confidence interval (CI) were used.
RESULTS: Eight studies were included in this meta-analysis. The pooled analysis of the included studies showed a statistically significant association between oxytocin augmentation and increased odds of PPH (pooled odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.05-1.53; I2 = 84.94%; p = 0.01). Publication bias was assessed using funnel plots, which appeared relatively asymmetrical, indicating significant publication bias. Galbraith plot and trim and fill plot were used for publication bias. Sensitivity analyses were performed by leave one out method.
CONCLUSION: This meta-analysis suggests that using oxytocin for labor augmentation is linked to a significant increase in the risk of PPH. It highlights the need for careful monitoring and consideration when using oxytocin, especially in low and middle-income countries where guidelines and supervision are crucial.
PURPOSE: To investigate the detectability of lymph node metastasis in patients with esophageal squamous cell carcinoma using a combination of dual-energy computed tomography (CT) and positron-emission tomography (PET) parameters.
METHODS: We analyzed dual-energy CT and PET preoperative data in 27 consecutive patients with esophageal squamous cell carcinoma (23 men, 4 women; mean age, 73.7 years). We selected lymph nodes with a short-axis diameter of ≥5 mm and measured CT values, iodine concentrations, fat fractions, long- and short-axis diameters, and ratio of long- and short-axis diameters. We performed visual assessment of lymph node characteristics based on dual-energy CT and determined the maximum standardized uptake value via PET. The measured values were postoperatively compared between pathologically confirmed metastatic and nonmetastatic lymph nodes. Stepwise logistic regression analysis was performed to determine factors associated with lymph node metastasis. Diagnostic accuracy was assessed via receiver operating characteristic curve analysis.
RESULTS: Overall, 18 metastatic and 37 nonmetastatic lymph nodes were detected. CT values, iodine concentrations, fat fractions, and the maximum standardized uptake values differed significantly between metastatic and nonmetastatic lymph nodes (p < 0.05). Stepwise logistic regression showed that iodine concentration and the maximum standardized uptake value were significant predictors of metastatic lymph nodes. The areas under the curve of iodine concentrations and maximum standardized uptake values were 0.809 and 0.833, respectively. The area under the curve of the combined parameters was 0.884, with 83.3% sensitivity and 86.5% specificity.
CONCLUSION: Combined dual-energy CT and PET parameters improved the diagnosis of lymph node metastasis in patients with esophageal cancer.
Patients who underwent intra-abdominal surgery by the Principal Investigator between January 1, 2011 and May 9, 2013 will be identified through patient medical records. Living patients will be contacted via letter from the Principal Investigator introducing the study along with the study's consent form for the patients' review. Interested patients will be consented either in person at the patient's next clinic visit or via telephone by a member of the study staff.
BACKGROUND: To compare pressure-controlled ventilation (PCV), volume-controlled ventilation (VCV), and pressure-controlled ventilation-volume guaranteed (PCV-VG) modes in patients undergoing spinal surgery in the prone position under general anesthesia.
METHODS: The study included 78 patients aged 20 to 80 years, American Society of Anesthesiologists 1-2, scheduled for lumbar spinal surgery. Patients included in the study were randomly divided into 3 groups Group-VCV; Group-PCV; Group-PCV-VG. Standard anesthesia protocol was applied. In addition to routine monitoring, train of four and BIS monitoring were performed. All ventilation modes were set with a target tidal volume of 6 to 8 mL/kg, FiO2: 0.40-0.45 and a respiratory rate of normocarbia. Positive end-expiratory pressure: 5 cm H2O, inspiration/expiration ratio = 1:2, and the maximum airway pressure:40 cm H2O. Hemodynamic, respiratory variables and arterial blood gases was measured, 15 minutes after induction of anesthesia in the supine position (T1), after prone position 15 minutes (T2), 30 minutes (T3), 45 minutes (T4), 60 minutes (T5), 75 minutes (T6), 90 minutes (T7).
RESULTS: There was no significant difference between the groups in patient characteristics. SAP, DAP, mean arterial pressure, and heart rate decreased after being placed in the prone position in all groups. Hemodynamic variables did not differ significantly between the groups. partial arterial oxygen pressure and arterial oxygen saturation levels in blood gas were found to be significantly higher in Group-PCV-VG compared to Group-PCV and Group-VCV in both the supine and prone positions. Ppeak and plateau airway pressure (Pplato) values increased and dynamic lung compliance (Cdyn) values decreased after placing the patients in the prone position in all groups. Lower Ppeak and Pplato values and higher Cdyn values were observed in both the supine and prone positions in the Group-PCV-VG group compared to the Group-PCV and Group-VCV groups.
CONCLUSION: PCV-VG provides lower Ppeak and Pplato values, as well as better Cdyn, oxygenation values compared to PCV and VCV. So that PCV-VG may be an effective alternative mode of mechanical ventilation for patients in the prone position during lumbar spine surgery.
PURPOSE:A dermal drug for external use, obtained by using urea and further elastin and/or elastin hydrolyzate protein together, and capable of improving the stability of the urea with time in the presence of water. CONSTITUTION:A dermal drug for external use, obtained by incorporating elastin and/or elastin hydrolyzate protein having several hundreds - several tens of thousands of molecular weight preferably in an amount of 1/10-10 times of that of urea as a dilute solution in a dermal drug for the external use containing 0.1-20wt% urea, and capable of improving the stability of urea with time in the presence of water. The effect is exhibited in case the urea is contained in the form of an aqueous solution in the base for the dermal drug for the external use. An aqueous solution of the urea may be in the form of emulsion with an oil phase, etc. However, if the individual base shows strong basicity, the emulsion is not preferred since the decomposition promoting action by the basic sub- stance sometimes is greater than the above-mentioned effect. The urea has expected wetting, cell activating and wound curing effect, etc. when incorporated in the dermal drug for external use.
Background: Studies in adult patients suggest cefepime can cause neurotoxicity, including disorientation, seizures, and coma, particularly when present at high concentrations. Patients with underlying kidney dysfunction or central nervous system anomalies are at particularly high risk. There is a relative paucity of pediatric literature on the neurotoxic effects of cefepime. Case Report: Herein is reported the case of a 2-year-old patient with chronic kidney disease receiving cefepime for Serratia marcescens bacteremia who experienced agitation, tremor, and inconsolability in the setting of an elevated cefepime trough that improved with cefepime discontinuation alone. Conclusions: Pediatric patients with acute and chronic kidney disease are at risk of cefepime-related neurologic changes. Therapeutic drug monitoring for cefepime in patients with kidney dysfunction or baseline neurologic abnormalities may help inform appropriate antimicrobial dosing and avoidance of toxicity.
The invention discloses application of PEDF in preparing medicine for diabetes bone tissue complication, and most diabetes patients have bone tissue complication, including osteoporosis, bone healing difficulty, gangrene and the like,. When PEDF expression levels of an osteoblast and osteogenic capability of a diabetes patient and a non-diabetes patient are compared, it is found that PEDF expression level of the non-diabetes patient is higher, and the osteogenic differentiation ability, the osteogenic efficiency and the calcium deposition level of the non-diabetes patient are higher than those of the diabetes patient (p<0.01). Exogenetic PEDF can up-regulate expression of osteogenic differentiation related genes OCN and Runx2. Compared with VEGF expression levels of the osteoblast of the two groups of the patients, it is found that the overall VEGF level of the non-diabetes patient is higher than that of a diabetes patient, and the exogenetic PEDF can up regulate expression of VEGF. PEDF can improve osteogenic differentiation ability of the osteoblast and calcium deposition level. PEDF can be applied to treating bone tissue complication caused by diabetes.
The utility model relates to a bigeminal capsule, particularly a novel preparation which comprises peroral medicines respectively in different capsule chambers in the same capsule and belongs to the field of medicine preparations. The preparation is composed of a normal capsule and capsule caps, wherein the normal capsule is externally sheathed with the capsule caps to form the two capsule chambers; the normal capsule and the capsule caps can be respectively gastrically dissolved and/or enterically dissolved capsules. Thus, a gastrically dissolved and gastrically dissolved capsule and an enterically dissolved and enterically dissolved capsule are respectively formed. A gastrically dissolved capsule cap is dissolved in a stomach to release the medicines into the stomach; an enterically dissolved capsule cap is dissolved in an intestinal tract to release the medicines into the intestinal tract. The same medicines and different preparations and different medicines or different medicine preparations can be placed in the two capsule chambers. The preparation can avoid the occurrence of the interaction of the medicines outside a body, extend the period of validity of the medicines and reduce medicine failure caused by the interaction among compound medicines. The utility model is favorable for making medicines with unstable physicochemical properties into compound preparations, which facilitates a quality analysis. Thus, clinical medicine combination is convenient, which improves patients'compliance.
PROBLEM TO BE SOLVED: To provide a composition, which has excellent stability though it includes (A) a quaternary ammonium salt-based preservative, has satisfactory sense of use, and is applicable to a mucous membrane, and to provide a composition applied to a mucous membrane, which has excellent stability though it includes (A) a quaternary ammonium salt-based preservative at a low concentration of ≤0.02 wt.%, has satisfactory sense of use, and is suitably used for the cleaning of a mucous membrane.SOLUTION: The composition applied to a mucous membrane includes: (A) a quaternary ammonium salt-based preservative; (B) edetic acid and/or its salt; and (C) polysorbate. In the composition, setting is performed so as to satisfy the ratios in which (C) polysorbate is set to 0.5 to 110 pts.wt. per 1 pt.wt. of (A) a quaternary ammonium salt-based preservative and (B) edetic acid and/or its salt is set to 0.001 to 1.5 pts.wt. to 1 pt.wt. of (C) polysorbate.
Background- Subclinical electrophysiological derangements occur at birth in foals. Smartphone-based ECG (spECG) is practical tools to assess heart rhythm and was recently validated in foals. Objectives-To assess the heart rate (HR) and rhythm at birth in clinically healthy foals born after spontaneous and induced parturition using a spECG. Animals- Newborn healthy foals born after at term spontaneous (SF) or induced foaling (IF). Methods- Cohort study. In SF and IF groups, a spECG was performed immediately at birth (T0) and after 5 min (T5). SpECG tracings were selected for quality. HR was manually calculated and was compared between groups and time-points. Tracings were manually interpreted for rhythm diagnosis. Results- Eighty-one spECG tracings owing to 42 healthy foals (36 SF, 6 IF) were of adequate quality. There were no significant differences in HR between SF and IF and between T0 and T5 (p > 0.05). Six foals were diagnosed with atrial fibrillation and 4 with sinus arrhythmia. Conclusions and clinical importance- The spECG was feasible and detected subclinical arrhythmias at birth. A potential relationship with induced foaling warrants confirmation. Provided good quality tracing is obtained, the device might assist in the clinical assessment at birth, especially in screening high-risk foals.
Participants in the Treatment As Usual condition will receive educational material on quitting smoking. Participants will be asked to complete questionnaire measures weekly for 8 weeks, with a final follow-up questionnaire at 12 weeks following study enrollment.