anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To enable immunomeasurement with excellent reproducibility, accuracy and sensitivity by measuring a material having antigenicity by using a sulfonation antibody obtd. by sulfonating an antibody for the material having antigenicity. CONSTITUTION:A material having antigenicity to be analyzed and measured is a low molecular and high molecular antigen and antibody, more specifically, immune globulin, an antigen specific to cancer such as AFP or CEA, an autoantibody such as anti-ENA antibody or the like, virus, etc. The sulfonation antibody is obtd. by sulfonating, for example, an antibody by the compd. which generates sulfite ion in water such as Na2SO4, Na2S2O5, etc. Ther measurement of the material having antigenicity by using such sulfonation antibody is accomplished preferably by a method of bonding the antibody to a solid carrier consisting of polystyrene, PP or the like and using the labeling sulfonation antibody labeled by a marker. Enzyme is used as the marker. The sulfonation antibody obtd. in the above-mentioned way causes hardly non-specific agglutination and exists stably for a long period of time.
Patients receive cyclophosphamide IV or PO over 1 hour, bortezomib IV over 3 minutes, and dexamethasone IV or PO on days 1, 8, and 15. Patients also receive pegylated liposomal doxorubicin hydrochloride IV over 1 hour on day 8. Treatment repeats every 28 days for up to 4 courses in the absence of disease progression or unacceptable toxicity.
Snake bite Envenomation is a Public Health Problem especially for tropical and subtropical countries. The WHO estimates 40 000 annual deaths in the world for this cause. In México the Ministry of Health estimated 3 882 cases on 2005, being the age of 15-44 the most affected. There are not official numbers of mortality, although the thought is that there are few cases of death, most of them related with a delay on treatment.

There are a broad variety of clinical presentations depending on many factors such as species, snake bite variability or patient conditions. Proteolytic action of venom produces amines and vasoactive peptides such as bradykinin, histamine and serotonin which cause capillary lesions with anticoagulant effects. Coagulopathy is one of the most important systemic consequences. The Dry Tube Test has been proposed as an indirect test to evaluate coagulopathy related to this pathology.
A system for multiphasic delivery of at least one growth factor at a treatment site comprises a delivery vehicle for releasing at least one growth factor in an initial release profile and a carrier for releasing at least one growth factor in a sustained release profile. The initial release profile releases at least one growth factor over a period of hours to days, wherein the growth factor is released in a large amount initially, with the remainder being released in progressively lower amounts. The sustained release profile releases at least one growth factor over a period of days to weeks, wherein the growth factor is released at a generally constant amount over such period. The system of the invention is particularly suited for applications on bioimplants. The invention also comprises methods and kits for multiphasic delivery of at least one growth factor. The invention also comprises calcium sulphate as a carrier for releasing at least one growth factor in both single and multiphasic systems for delivering at least one growth factor at a treatment site.
In the present invention, a training device is appropriately controlled by correctly monitoring the load during operation and differences in position deviation changes. This training device (100) is provided with an immobile frame (1), an operation rod (3), a motor, a rotational information detection sensor, a tilt angle calculation unit (1131), a feedback current detection unit (1133), a position deviation calculation unit (1132), and a determination unit (1134). The operation rod (3) tilts with at least one degree of freedom. The motor tilts the operation rod. The rotational information detection sensor detects the amount of rotation of the motor. The tilt angle calculation unit (1131) calculates the tilt angle. The feedback current detection unit (1133) detects a feedback current value (I). The position deviation calculation unit (1132) calculates a position deviation each time a first time (T 1 ) elapses. The determination unit (1134) determines that there is an error when the position deviation arising between the first times (T 1 ) is at least a first threshold (φ 1 ), or when the feedback current value (I) is at least a first current value (I 1 ) for at least a second time (T 2 ).
Virtual reality (VR) experience VR visualization of a 3-dimensional relaxing nature scene with the accompanying audio. The patient will be offered a selection of scenes from which to choose, played continuously on a Samsung Gear VRTM(San Jose, CA) headset and headphones. The goal is for the patient to use the intervention for the entire duration of the external cephalic version procedure (ECV), which typically lasts 15 - 30 minutes.The patient will also receive verbal reassurance and coaching as needed. The obstetrician will communicate as usual with the patient.
Dilute and prepare RYBREVANT for intravenous infusion before administration.

  * Check that the RYBREVANT solution is colorless to pale yellow. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if discoloration or visible particles are present.
  * Determine the dose required and number of RYBREVANT vials needed based on patient's baseline weight [see Dosage and Administration (2.3)] . Each vial of RYBREVANT contains 350 mg of amivantamab-vmjw. 
  * Withdraw and then discard a volume of either 5% Dextrose Injection or 0.9% Sodium Chloride Injection from the 250 mL infusion bag equal to the volume of RYBREVANT to be added (i.e., discard 7 mL diluent from the infusion bag for each RYBREVANT vial). Only use infusion bags made of polyvinylchloride (PVC), polypropylene (PP), polyethylene (PE), or polyolefin blend (PP+PE).
  * Withdraw 7 mL of RYBREVANT from each vial and add it to the infusion bag. The final volume in the infusion bag should be 250 mL. Discard any unused portion left in the vial.
  * Gently invert the bag to mix the solution. Do not shake.
  * Diluted solutions should be administered within 10 hours (including infusion time) at room temperature 15°C to 25°C (59°F to 77°F).
It has been shown that chronic restraint stress (CRS) increases adrenal 5-HT levels and turnover through a mechanism that appears unrelated to tryptophan hydroxylase (TPH). In the present study we re-analyzed the effects of CRS (20 min/day) for 14 days relative to control (CTRL) conditions on TPH expression, distribution, and activity in rat adrenal glands. On day 15, adrenal glands were collected for TPH1 and TPH2 immunohistochemistry, Western blot, and RT-PCR; TPH activity was estimated by quantification of 5-hydroxytryptophan (5-HTP) and, indirectly, through measurement of 5-HT and 5-hydroxindolacetic acid (5-HIAA) levels and turnover (5-HIAA/5-HT ratio) by HPLC. TPH expression and activity in the dorsal raphe nucleus (DRN) were also determined for comparison. TPH1 and TPH2 immunostaining was observed in the adrenal medulla, and measurable levels of TPH1 and TPH2 protein and mRNA were detected in rat adrenal glands from CTRL animals. CRS exposure noticeably increased TPH2- but not THP1-immunostaining in the medulla and the outer adrenocortical areas of left (LAG) but not of right adrenal glands (RAG). In addition, CRS exposure increased TPH2 protein and mRNA levels in LAG; however, both measures decreased in DRN. Finally, CRS treatment produced an increase and a decrease of TPH activity and 5-HT turnover in LAG and DRN, respectively. Results indicate that TPH is indeed expressed in rat adrenal glands. Exposure to CRS upregulates TPH2 in LAG, while inducing downregulation of it in the DRN. Then, the increased levels of 5-HT in LAG from CRS-exposed animals likely results from TPH2-mediated synthesis.
OBJECTIVES: Acute central serous chorioretinopathy (CSC) and Vogt-Koyanagi-Harada (VKH) disease in the acute uveitic phase are characterized by serous retinal detachment caused by dysfunction of the choroid. The aim of this study is to compare blood flow velocity and pulse waveform parameters in the choroid between these two diseases.
METHODS: In this study, 25 patients (50 eyes) with VKH disease, 21 patients (27 eyes) with CSC and 15 healthy controls (30 eyes) were studied. Laser speckle flowgraphy (LSFG) was performed at presentation.
RESULTS: Choroidal mean blur rate (MBR), representing blood flow velocity in choroidal vessels, was significantly lower in the eyes affected by VKH disease compared with the healthy control and CSC eyes. CSC eyes had a significantly higher MBR compared with healthy controls. Among the analyzed pulse waveform parameters, blow-out time (BOT), falling rate (FR) and flow acceleration index (FAI) changed significantly. BOT value was significantly lower in CSC eyes than in healthy control and VKH eyes. FR and FAI values were significantly lower in VKH eyes than in healthy control and CSC eyes. There was a strong positive correlation between MBR and FAI.
CONCLUSIONS: Our findings confirm different pathophysiology of these two diseases. Assessment of choroidal blood flow velocity and haemodynamics with LSFG provides useful information to differentiate acute CSC and initial-onset acute uveitis associated with VKH disease.
In recent years, the highest rates of HIV in the U.S. have been concentrated among young men who have sex with men (MSM), especially those of color. Unfortunately, evidenced-based intervention programs for non-heterosexual Black adolescent males (nHBAM) do not exist. Drs. Brown and Crosby have each designed, tested (in the context of NIH-funded RCTs) behavioral interventions targeting young people at-risk of HIV acquisition. Also, their previous work demonstrates that parental involvement prevents sexual risk behavior by adolescents. They will adapt key elements of STYLE, an efficacious HIV prevention program for adolescents and their parents/caregivers, to be relevant for nHBAM. A formative phase will use in-depth interviews to assess and identify the needs of nHBAM and their parents/caregivers. Work groups, composed of youth, parents/caregivers, stakeholders, and investigators, will tailor and refine the content in an iterative process with a sophisticated media company (MEE studios). MySTYLE is proposed to be a series of eight online novella episodes designed to increase relevant knowledge, attitudes, and sexual protective behaviors of nHBAM. The project will take place in Jackson MS, which has the highest prevalence of HIV among urban MSM in the U.S. and the third highest rate among Black MSM under the age of 25. Adolescents and parents will be recruited from community organizations, medical clinics and schools. The feasibility and effect sizes of MySTYLE, compared to a waitlist control group, will be tested with a cohort of 72 nHBAM and their parents. Interventions effect sizes will be determined for sexual behaviors, HIV testing, and psychosocial mediators (e.g., knowledge, attitudes, communication between adolescents and their parents/caregivers relative to sex, safer sex, and sexuality).
BACKGROUND: Time-dependent changes in cell populations during acute bacterial infections remain unclear. We assessed time-dependent changes in fluorescent light intensity of the neutrophil area (NE-SFL) and fluorescent light distribution width index of the neutrophil area (NE-WY) and their association with sepsis and bacteremia.
METHODS: Patients with acute bacterial infections were enrolled in this prospective, observational cohort study. Blood samples were collected from all patients at the onset of bacterial infections (day 0) and on days 1 and 3. Microbiological evaluation included the examination of blood bacterial load using PCR. Cell population data were assessed using an automated hematology analyzer (Sysmex series XN-2000).
RESULTS: Forty-three participants with acute bacterial infections were enrolled in the study. Twenty-five participants developed definite sepsis. All the participants improved after the onset of infection. NE-WY levels showed significant time-dependent changes in participants with sepsis, peaking on day 0 and significantly decreasing until day 3, whereas these changes were not statistically significant for NE-SFL. A significant correlation with the Sequential Organ Failure Assessment score was observed with NE-WY and NE-SFL in the entire cohort on days 0 and 1. However, only NE-WY showed a significant correlation with blood bacterial load on days 0 and 1.
CONCLUSION: This study demonstrated that NE-WY elevation in sepsis peaked earlier than NE-SFL, which may partly reflect the early bacterial invasion into circulation. These findings advocate caution in interpreting cell population data values as sepsis biomarkers and propose the potential of NE-WY as a therapeutic indicator.
FIELD: chemistry. ^ SUBSTANCE: method involves steps for reducing the terminal monosaccharide link of sialic acid to obtain a reduced monosaccharide link of sialic acid, hydrolysis of the saccharide to obtain a hydrolysate containing monosaccharide links. The saccharide contains monosaccharide links of sialic acid which are 2åÆ9 bonded, and a terminal monosaccharide link of sialic acid. Further, the ratio of the total amount of sialic acid to amount of the reduced sialic acid in the hydrolysate is determined. The invention enables to measure the degree of polymerisation of saccharides and evaluation of the quality of vaccines which contain saccharides. ^ EFFECT: high accuracy and reliability of the method. ^ 13 cl, 23 dwg, 9 tbl
Method and system for the analysis and source localization of the dynamical patterns in medical and health data, and linking such dynamical patterns with the individual's genetic and/or molecular data. The invention makes use of optimally positioned sensors (sensor arrays) providing input data for signal processing, time-series analysis, pattern recognition and mathematical modeling to facilitate dynamical tracking of systemic arterial pressure without a pressure cuff, local vascular activity, electrocardiographic (ECG), respiratory, physical, muscular, gastrointestinal and neural activity, temperature and other physiological/health data. The invention also facilitates separation of local signals (such as local aneurisms or local vascular activity) from non-local, central or systemic patterns (e.g. systemic blood pressure). In addition, the invention improves identification of dynamical patterns associated with a specific genotype/disorder for screening, personalized risk assessment, diagnosis and treatment control. The system can be implemented in a specialized processor, such as an ambulatory blood pressure monitor, Electrocardiograph, Holter monitor located outside subject's body or implanted inside the body, mobile/cell phone or Smart Phone/Personal Digital Assistant, computer or computer network (the Internet), including wireless or mobile network. The system can be also linked to the electronic health/medical records and other databases.
A solid understanding of fractions is the cornerstone for acquiring proficiency with rational numbers and paves the way for learning advanced mathematical concepts such as algebra. Fraction difficulties limit not only students' educational and vocational opportunities but also their ability to solve everyday problems. Students who exit sixth grade with inadequate understanding of fractions may experience far-reaching repercussions that lead to lifelong avoidance of mathematics. This article presents the results of a randomized controlled trial focusing on the first two cohorts of a larger efficacy investigation aimed at building fraction sense in students with mathematics difficulties. Teachers implemented an evidence-informed fraction sense intervention (FSI) within their sixth-grade intervention classrooms. The lessons draw from research in cognitive science as well as mathematics education research. Employing random assignment at the classroom level, multilevel modeling revealed a significant effect of the intervention on posttest fractions scores after controlling for pretest fractions scores, working memory, vocabulary, proportional reasoning, and classroom attentive behavior. Students in the FSI group outperformed their counterparts in the control group, with noteworthy effect sizes on most fraction measures. Challenges associated with carrying out school-based intervention research are addressed.
The invention relates to a water lily root herbal extract moisture-retention hand sanitizer, which is characterized by selecting and using pure natural herbal cleansing component. The fine hand sanitizer is prepared through a special process. The formula of the hand sanitizer comprises effective components of water lily root herbal extract, coconut oil sulfobetaine, coconut oleyl alcohol polyoxyethylene ether sodium sulfate, glycerol, and EDTA-Na. The water lily root herbal extract is a precious plant stem cell component and a novel active cosmetic component, which fuses international cutting-edge technology of precision fractional distillation, and is used for aging skin to reduce fine lines on surface layer and to effectively reduce deep wrinkles. The hand sanitizer has unique skin activating and protection effect to establish a good maintenance function for skin and to effectively delay skin aging, so that beautiful and young appearance will be kept. The water lily root herbal extract has a peculiar herbal cleansing component and the hand sanitizer has fine foam and soft touch, which not only can be used for deeply cleaning hand skin, but also can nourish hands to tighten, smooth and soften skin without making skin dry and oily, and is suitable for daily use by people in different ages to help hand skin to keep lasting health.
The invention provides an externally applied drug for treating burns and scalds. The externally applied drug is characterized by comprising by mass, 5 to 12% of aloe powder, 30 to 50% of peanut oil, 35 to 50% of sesame oil and 5 to 15% of millet powder. The externally applied drug has multiple effects belonging to peanut oil, sesame oil, aloe and millet. Through external application, the externally applied drug can fast eliminate swelling, relieve pain, remove heat, promote fast growth of muscle and tendon and fast healing of wounds, prevent effectively bacterial growing on the surface of a wound, and prevent cross infection. Operations of skin-grafting and beauty treatment are not needed after large-area burns and scalds are treated by the externally applied drug. The pain can be relieved after the externally applied drug is applied to the surface of a wound for 15 minutes, and the wound heals without scarring after the externally applied drug is applied to the wound for about 15 days. Therefore, the externally applied drug has special effects of treatment burns and scalds.
The exercise will be 30 minutes of treadmill walking. During the initial stages of walking, participants will gradually be taken up to a speed that registers between 10 and 12 on the Borg Rating of Perceived Exertion (RPE) Scale, up to a maximum of 4.0 km/h. This speed will be fixed for the entire exercise period. This exercise intensity has been chosen as it is the exercise intensity matched to light-moderate physical activity.
The present disclosure is related to the extraction of prickly pear mucilage from the part called parenchyma, that is to say, the soft part and that is in the center of the cactus Phylloclades with an age of two to four years old; time in which the soft part has developed. No solvent is used for the extraction of the cactus mucilage or high temperatures to obtain the mucilage. The parenchyma is used because it has a greater amount of sticky substance; this is an advantage over other mucilage extraction methodologies where all the Phylloclade is used, therefore, high temperature, organic type solvents must be used for the extraction. The technique consists in sectioning the parenchyma of the cactus Phylloclades, that is, the softest part and placing it in a container containing a metal mesh fabric with holes of 5 mm in diameter to retain parts of the cactus heart that can sneak when adding, mixing and resting speed of approximately 40 minutes. The mucilage passes to another metal mesh fabric with perforations of 0.177 mm in diameter, which allows only the passage of the mucilage and the water that it contains by nature. The mucilage is collected in a container that is preferably amber and refrigerated to achieve precipitation of the mucilage and water, this precipitate is placed in a separation flask to promptly separate the water from the mucilage. Once the mucilage is separated from the water, the mucilage without water is again deposited in an amber container to place it at refrigeration temperature until use.
Following discontinuation of L-thyroxine (T4), triiodothyronine (T3) will be initiated at a 3:1 ratio. The dose will be titrated by the investigator to maintain levels of free T4 \< 50% of normal range while maintaining a euthyroid state. Triiodothyronine (T3) tablets for oral administration will be prescribed once or twice daily depending on the total dose. Treatment duration will be approximately 9 months during which time the subjects will continue to be treated and monitored as usual for their metastatic breast cancer. During the study period and at the conclusion of the study period, there will be continuous evaluations of the disease status and thyroid status with the option of resuming the original thyroid replacement or continuation of the triiodothyronine (T3).
A technique for dynamic generation of a therapeutic derivative story includes obtaining attribute data that describes characteristics of a content consumer along with situational details describing an emotional situation involving the content consumer. A relatability score for the therapeutic derivative story is determined. A content data structure (CDS) is selected. The CDS specifies story elements of a preexisting story. The story elements are associated with metadata constraints that constrain modification or use of the story elements. The metadata constraints indicate whether associated ones of the story elements are mutable story elements. One or more of the mutable story elements are adapted based on the attribute data or the situational details as constrained by the metadata constraints and to an extent determined at least in part by the relatability score to generate the therapeutic derivative story.
The protocol for patients assigned to medical group was as follows. ASUC patients were admitted in, estimated their baseline situations and tested their blood and fecal indicators including PCT, IL-6 and FC on admission. All patients were treated according to the ECCO guideline 2012. Patients who showed response to medicine (glucocorticoid for 5 days or rescue therapy for 3 days) were classified in the medical group. Their baseline manifestations were collected and compared with the surgery group.