anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A system and method for monitoring the inventory of a medical storage container such as a tray that has a required inventory of medical articles. An enclosure is used to isolate, scan, and take an inventory of the tray or other container of medical articles. The tray and each of the medical articles in the tray have RFID tags. The enclosure having a size differing from the size needed for a resonant frequency at the RFID frequency of operation of the tags. A probe is used to create a robust electromagnetic field standing wave of constructive interference in the enclosure and a program compares the scanned present inventory of the tray to the required inventory database and indicates any differences. Expired and recalled articles and substitutes for recalled articles are identified.
Vascular graft infections (VGI) pose a significant challenge in vascular surgery, characterized by substantial morbidity and mortality. This review delves into the epidemiology, pathogenesis, microbiology, risk factors, and clinical presentation of VGI. It highlights diagnostic criteria and methodologies, including imaging techniques and laboratory tests. Comprehensive management strategies, involving antimicrobial therapy, surgical intervention, and preventive measures, are discussed. Emphasis is placed on the multidisciplinary approach required for effective treatment, alongside emerging trends in VGI microbiology and innovative therapeutic options. This review article aims to provide a detailed understanding of VGI for improved clinical outcomes.
Locally advanced HER2+ breast cancer patients that receiving neoadjuvant combination therapy including Herceptin will undergo two contrast-enhanced \[18F\]FMISO PET/MRI imaging. Imaging session one will be after diagnosis and before beginning combination therapy. Imaging session two will be within 10 days prior to beginning the second round of combination therapy with targeted HER2 agents.
FIELD: medicine, medicinal microbiology. SUBSTANCE: method involves growing two strains of Corynebacterium KT N 226 and KT N 227 in separate tubes on modified nutrient medium containing dried nutrient agar and 0.2 ± 0.05% glucose and 0.15 ± 0.05% Tween, pH = 7.7 ± 0.1. Grown culture is washed out from each tube with 0.9% sodium chloride solution and obtained dense suspension is diluted to 10 U turbidity. Then suspensions are combined at equal volumes and heated at 80 ± 1 C for 1 h on water bath for inactivation. Obtained preparation promotes immunocorrection. EFFECT: improved method of preparing. 3 cl
PCT No. PCT/JP94/01807 Sec. 371 Date Apr. 29, 1996 Sec. 102(e) Date Apr. 29, 1996 PCT Filed Oct. 27, 1994 PCT Pub. No. WO95/11966 PCT Pub. Date May 4, 1996A human Activated Protein C preparation with a high specific activity of 3500 U/mg or more and substantially free from thrombin or other proteases which can convert Protein C into Activated Protein C is provided. A process for preparing this human Activated Protein C, which involves, contacting a solution of human Activated Protein C, after activation of Protein C with thrombin or other activating protease, with a cation exchanger to allow for adsorption of both thrombin or another activating protease and Activated Protein C to the cation exchanger followed by elution of the human Activated Protein C alone.
Subjects who meet the eligibility criteria will be classified into intervention and control groups based on their Qur'an listening routine. Those who listen to the Qur'an less than once a week will be included in the control group. On the other hand, those who listen to the Qur'an once or more a week will be included in the intervention group. Before the intervention, we will also evaluate the potential confounding factors in each respondent that could affect quality of life, such as SLE clinical manifestations, disease activity, pharmacologic treatment regimen, anxiety or depression, comorbidities, and economic status.

Subjects in the intervention group will be asked to listen to the Al Qur'an recital (QS. Ar-Rahman) with a minimum duration of 15 minutes each, twice every day for 40 days, through an MP3 player using a headset or earphone. They will listen to the same Qur'an recital that is recited by Freed Ghalib. To ensure the respondents listen to the Qur'an recital Surah Ar-Rahman, the researcher will call and message via the Whats App application to research subjects every day for reminding. Respondents are also given a checklist card that will be filled out each time they are finished listening to the Qur'an recital. The control group will be asked not to change their habits of listening to or reading the Qur'an during this period. In addition, both the intervention and control groups will also be asked to inform the researchers if they read the Qur'an during the intervention or monitoring period.
OBJECTIVE: Olfactory and gustatory functions are important sensory aspects in humans. Although they are believed to influence each other, their interrelationship is not well understood. In this study, we aimed to investigate the relationship between the olfactory and gustatory functions based on the results of a large-scale epidemiological study (Iwaki Health Promotion Project) of the general local population.
METHODS: We analyzed 565 participants who underwent taste and olfactory tests in the 2019 Iwaki Project. Gustatory function was tested for four taste qualities (sweet, sour, salty, and bitter) using whole-mouth taste tests. Olfactory function was tested using the University of Pennsylvania Smell Identification Test modified for Japanese (UPSIT-J). We evaluated sex-related differences between olfactory and gustatory functions and the effects of various factors on olfactory identification using multivariate analysis. Furthermore, we compared the percentage of accurate UPSIT-J responses between the normal and hypogeusia groups. We also analyzed the effects of taste and olfactory functions on eating.
RESULTS: Olfactory and gustatory functions were lower in men than in women. Among the four taste qualities, salty taste was the most closely associated with olfactory identification ability, with lower olfactory scores of salty taste in the hypogeusia group than in the normal group. Moreover, the hyposmia group had higher daily salt intake than the normal olfaction group in women.
CONCLUSION: These results suggest that olfactory identification tests may be useful in predicting elevated salt cognitive thresholds, leading to a reduction in salt intake, which may contribute to hypertension prevention.
Aim: Tuberculous meningitis (TBM) often causes cerebral infarction, but its predictive factors are not well understood. Methods: Patients aged ≥13 years admitted with TBM were enrolled prospectively. Cerebral infarction was diagnosed using magnetic resonance imaging. Results: Of 186 patients, 80 (43%) had infarction. Most infarctions were multiple and located in the cortical areas, basal ganglia and subcortical regions. Independent predictors of infarction at admission included high blood pressure, short illness duration, low Glasgow coma scale and hydrocephalus. Neuroimaging inflammation signs, cerebrospinal fluid analysis abnormalities and pre-existing cardiovascular risks did not predict infarction. In-hospital mortality was higher in TBM with infarction, particularly in those with advanced TBM (stage 3). Conclusion: Baseline parameters of raised intracranial pressure predict cerebral infarction in TBM.
Methods and apparatus for the application of reinforcement learning to animal medical diagnostics. In one embodiment, a system is disclosed that utilizes two (2) RL  agents that are arranged sequentially and that are optimized independently from one another. The first RL agent is an assessment RL agent which takes as input from one or more of: outputs from classification artificial intelligence (AI) engines;  outputs from subjective biological data storage devices, and outputs from objective biological data storage devices. Using these input(s), the assessment RL agent outputs a set of assessments which evaluate a set of conditions associated with an animal. This set of assessments is then provided as input to a second RL agent known-as a plan RL  agent which determines a set of treatment recommendations and diagnostics based off this determined set of assessments. Methods and computer-readable media are also disclosed.
BACKGROUND: Little attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whether small airway inflammation (SAI) was the risk for the development of COPD.
METHODS: A total of 1062 patients were enrolled and analyzed in the study. The partitioned airway inflammation was determined by exhaled nitric oxide (NO) of FnNO, FeNO50, FeNO200, and calculated CaNOdual. Both FeNO200 and CaNOdual were compared to detect the promising predictor for peripheral airway/alveolar inflammation in COPD. The correlation between exhaled NO and white cell classification was evaluated to determine the inflammation type during the development of COPD.
RESULTS: Exhaled NO levels (FnNO, FeNO50, FeNO200, and CaNOdual) were the highest in the COPD group compared with all other groups. Furthermore, compared with controls, exhaled NO levels (FeNO50, FeNO200, and CaNOdual) were also significantly higher in the emphysema, chronic bronchitis, and smoking groups. FeNO200 was found to be a promising predictor for peripheral airway/alveolar inflammation (area under the curve [AUC] of the receiver operating characteristic [ROC] curve, area under the curve [AUC] = 0.841) compared with CaNOdual (AUC ROC = 0.707) in COPD. FeNO200 was the main risk factor (adjusted odds ratio, 2.191; 95% CI, 1.797-2.671; p = 0.002) for the development of COPD. The blood eosinophil and basophil levels were correlated with FeNO50 and FeNO200.
CONCLUSION: The complete airway inflammations were shown in COPD, whereas SAI was the main risk factor for the development of COPD, which might relate to eosinophil and basophil levels.
An antifungal nano-material based on dynamic covalent bonds, a preparation method and application thereof, and belongs to the field of biomedical materials. Firstly, synthesizing alpha-aminophosphonate derivative lipid (lipid molecule) modified with different carbon chain lengths and containing catechol, reacting the lipid molecule with antifungal drugs in an organic solvent, concentrating, adding a phosphate buffer solution, and ultrasonically oscillating until the organic solvent is completely volatilized, thereby obtaining the antifungal nanomaterial, wherein the structure of the antifungal nanomaterial is shown as a formula I. The invention utilizes dynamic covalent bonds to construct antifungal nano materials to realize antifungal drugs and lipid moleculesDynamic combination, achieving the aim of drug responsive release. Has effects in killing Candida albicans and inhibiting growth of biofilm. Can be used for treating vulvovaginal candidiasis. Compared with the traditional lipid nano-drug, the system realizes drug release under specific conditions in a dynamic covalent chemical combination mode, and can avoid the problems of drug burst release and the like of the lipid nano-drug in blood.
PURPOSE:To provide excellent disinfecting detergency and to peel and decom pose away proteins and fats by compounding a specific anion surfactant with sodium hypochlorite. CONSTITUTION:The disinfecting for medical treating equipment for artificial dialysis, etc., contains the anion surfactant of an alkyl ether sulfate ester salt or alkyl phenyl ether sulfate ester salt system, the sodium hypochlorite and the stabilizer thereof, and ethylenediaminetetraacetic acid as essential components. The specific anion has general formula. The specific anion does not decompose even if a strong alkali agent is compounded with a sodium hypochlorite soln. contg strong alkali agent. The detergency of this specific anion and the sodium hypochlorite act synergistically to provide the effect of removing the proteins and fats sticking to the inside of the piping of the equipment simultaneously with sterilization and disinfection.
Sebelipase alfa is a recombinant human lysosomal acid lipase (rhLAL) that is a lysosomal glycoprotein enzyme produced by recombinant DNA technology in the egg white of eggs laid by genetically engineered chickens. Purified sebelipase alfa is a monomeric glycoprotein containing 6 N-linked glycosylation sites and has a molecular mass of approximately 55 kDa. The amino acid sequence for sebelipase alfa is the same as the amino acid sequence for human LAL. The specific activity of sebelipase alfa is 195 to 345 units/mg. One unit is the amount of enzyme activity that catalyzes the hydrolysis of 1 micromole of the synthetic substrate 4-methylumbelliferyl oleate per minute at 37°C under specified assay conditions.

KANUMA (sebelipase alfa) injection is supplied as a sterile, preservative-free, non-pyrogenic clear to slightly opalescent, colorless to slightly colored aqueous solution in single-dose vials for intravenous infusion. Each vial contains sebelipase alfa 20 mg/10 mL. Each mL of solution contains sebelipase alfa (2 mg), citric acid monohydrate (1.57 mg), Human Serum Albumin (10 mg), and trisodium citrate dihydrate (13.7 mg) at pH 5.9.
Pregnancy Category C. Nimodipine has been shown to have a teratogenic effect in Himalayan rabbits. Incidences of malformations and stunted foetuses were increased at oral doses of 1 and 10 mg/kg/day administered (by gavage) from day 6 through day 18 of pregnancy but not at 3 mg/kg/day in one of two identical rabbit studies. In the second study an increased incidence of stunted fetuses was seen at 1 mg/kg/day but not at higher doses. Nimodipine was embryotoxic, causing resorption and stunted growth of fetuses, in Long Evans rats at 100 mg/kg/day administered by gavage from day 6 through day 15 of pregnancy. In two other rat studies, doses of 30 mg/kg/day nimodipine administered by gavage from day 16 of gestation and continued until sacrifice (day 20 of pregnancy or day 21 post partum) were associated with higher incidences of skeletal variatio n, stunted fetuses and stillbirths but no malformations. There are no adequate and well controlled studies in pregnant women to directly assess the effect on human fetuses. Nimodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Cardiomyocyte survival is a critical contributing process of host adaptive responses to cardiovascular diseases (CVD). Cells of the cardiovascular endothelium have recently been reported to promote cardiomyocyte survival through exosome-loading cargos. Sphingosylphosphorylcholine (SPC), an intermediate metabolite of sphingolipids, mediates protection against myocardial infarction (MI). Nevertheless, the mechanism of SPC delivery by vascular endothelial cell (VEC)-derived exosomes (VEC-Exos) remains uncharacterized at the time of this writing. The present study utilized a mice model of ischemia/reperfusion (I/R) to demonstrate that the administration of exosomes via tail vein injection significantly diminished the severity of I/R-induced cardiac damage and prevented apoptosis of cardiomyocytes. Moreover, SPC was here identified as the primary mediator of the observed protective effects of VEC-Exos. In addition, within this investigation, in vitro experiments using cardiomyocytes showed that SPC counteracted myocardial I/R injury by activating the Parkin and nuclear receptor subfamily group A member 2/optineurin (NR4A2/OPTN) pathways, in turn resulting in increased levels of mitophagy within I/R-affected myocardium. The present study highlights the potential therapeutic effects of SPC-rich exosomes secreted by VECs on alleviating I/R-induced apoptosis in cardiomyocytes, thereby providing strong experimental evidence to support the application of SPC as a potential therapeutic target in the prevention and treatment of myocardial infarction.
Multiple doses of finafloxacin once daily (o.d.) for 7 days at dose levels of 800 mg i.v.
BACKGROUND: Poly ADP-ribose polymerase (PARP) inhibitors are approved for the treatment of some men with advanced prostate cancer. Rare but serious side effects include myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The impact of PARP inhibitors on clonal hematopoiesis (CH), a potential precursor lesion associated with MDS and AML, is incompletely understood in prostate cancer. We hypothesized that PARP inhibitors would increase CH prevalence and abundance.
METHODS: We prospectively enrolled participants with advanced prostate cancer treated with PARP inhibitors. The presence of CH was assessed from leukocytes using an ultra-deep error-corrected dual unique molecular identifiers sequencing method targeting 49 genes most commonly mutated in CH and myeloid malignancies. Variant allele frequencies (VAF) of ≥0.5% were considered clinically significant. Blood samples were collected before and after PARP inhibitor treatment.
RESULTS: Ten men were enrolled; mean age of 67 years. Six patients had Gleason 7 disease, and four had Gleason ≥8 disease at diagnosis. Nine had localized disease at diagnosis, and eight had prior treatment with radiation. The mean time between pre- and post-treatment blood samples was 11 months (range 2.6-31 months). Six patients (60%) had CH identified prior to PARP inhibitor treatment, three with multiple clones. Of 11 CH clones identified in follow-up, 5 (45%) appeared or increased after treatment. DNMT3A, TET2, and PPM1D were the most common CH alterations observed. The largest post-treatment increase involved the PPM1D gene.
CONCLUSION: CH alterations are frequently found after treatment with PARP inhibitors in patients with prostate cancer and this may be one mechanism by which PARP inhibitors lead to increased risk of MDS/AML.
With the growing numbers of children with dyspraxia in Hong Kong, the focus of paediatric rehabilitation services has shifted from severe motor disorders (e.g., cerebral palsy) to relatively minor motor problems such as developmental coordination disorder (DCD). Evidence-based treatment strategies must be developed to suit this changing need. Children diagnosed with DCD are characterised by marked impairment in motor functions. Poor balance ability is a major concern because it may predispose children to falls and affect their motor skill development. At present, rehabilitation regimes for DCD-affected children use functional movement training (FMT) to induce neural plastic changes in the central nervous system (CNS) and thus enhance functional (balance) performance. Less emphasis is placed on treating the neuromuscular impairments that might also affect functional outcomes. Recently, the investigators research team discovered that slowed hamstring muscle force production, a neuromuscular deficit, may be one of the causes of poor balance strategies in children with DCD, but no effective treatment strategy has yet been examined. Power training (PT) has been found to be effective in increasing the speed of muscle force production and balance in adults through various neuromuscular mechanisms. In this study, the investigators intend to treat both the CNS and peripheral neuromuscular deficits in DCD-affected children. Therefore, the investigators will incorporate PT into a conventional FMT regime. The investigators hypothesise that balance strategies and functional performance in children with DCD will be improved most by treating both the CNS and neuromuscular deficits. This hypothesis will be supported by the finding that PT with FMT is superior to FMT alone in improving balance strategies and functional performance in children with DCD.

Objective: To compare the effectiveness of PT-FMT, FMT alone and no intervention in improving balance strategies and performance among children with DCD. Design: A randomised controlled clinical trial. Sample: 87 children with DCD. Interventions: 12 weeks of PT and FMT or FMT alone in the two intervention groups.

Major outcomes: Sensory organisation test - balance strategy and composite scores; Movement Assessment Battery for Children - total impairment score and balance subscore; hand-held dynamometer measurements of lower limb muscle strength and time to peak force.

Anticipated results and clinical significance: DCD-affected children who receive FMT together with PT will have the best balance performance outcomes. If the results are positive, this training programme could be readily transferrable to clinical practice. This could have positive socio-economic implications, such as shorter treatment periods and reduced healthcare costs.
<P>PROBLEM TO BE SOLVED: To compose metal colloid only from natural sources.  <P>SOLUTION: A metal ion solution and a pH compensation agent are added to a treatment liquid obtained by adding a surfactant to water, and stirring is performed while the temperature of the treatment liquid is controlled in a reducing atmosphere, thus the metal ions are reduced to produce metal colloid. The produced metal colloid is noble metal colloid in which the metal is gold, silver, the platinum group or the like. As the reducing agent, low molecular weight alcohol is used. As the surfactant, glycerol fatty acid ester is used. As the metal ion solution, a solution of the acids of chlorinated noble metal is used. As the pH compensation agent, sodium hydrogen carbonate is used. The metal colloid is produced at a pH from a neutral region to a weak alkali region. Regarding its oxidation-reduction potential after the completion of the reduction reaction, it is a negative electric charge, and a negative potential higher than (-)200 mV is shown.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
This invention relates to methods for making a three-dimensional dental prosthesis using ink-jet printing systems. An ink-jet printer is used to discharge light-curable, wax-like polymerizable material in a layer-by-layer manner to build-up the prosthesis. The methods are particularly useful for making integrated dentures containing a set of artificial teeth. The denture base and set of teeth are made of light-curable, wax-like polymerizable materials comprising a mixture of monomer, oligomer, and light sensitizer. The wax-like materials are dimensionally stable in their uncured states. The denture base and artificial teeth are later light-cured to form a polymerized denture product having high flexural modulus and flexural strength.
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is stimulated in order to reduce the level aggregration. For purposes of screening agents for treatment of neurodegenerative disease, oxidative stress in the neuronal cells is stimulated by introducing a mixture of metal-ions and hydrogen peroxide. Examples of appropriate metals include iron, aluminum, and copper. After introduction of the agent under evaluation for stimulation of expression of non-amyloidogenic protein, the effectiveness is measured by testing for a decrease in the level of aggregation of NACP/α-synuclein. In an exemplary embodiment, the non-amyloidogenic protein is β-synuclein. The aggregation of NACP/α-synuclein is dependent upon the concentration of metal ions in the neuronal cells. In addition, the presence of chelating agents appears to modulate the build-up of NACP/α-synuclein aggregates which are responsible for synaptic and neuronal dysfunction.