anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cholangiocarcinoma (CCA) is a rare but highly invasive cancer, with its incidence rising in recent years. Currently, surgery remains the most definitive therapeutic option for CCA. However, similar to other malignancies, most CCA patients are not eligible for surgical intervention at the time of diagnosis. The chemotherapeutic regimen of gemcitabine combined with cisplatin is the standard treatment for advanced CCA, but its effectiveness is often hampered by therapeutic resistance. Recent research highlights the remarkable plasticity of tumor-associated macrophages (TAMs) within the tumor microenvironment (TME). TAMs play a crucial dual role in either promoting or suppressing tumor development, depending on the factors that polarize them toward pro-tumorigenic or anti-tumorigenic phenotypes, as well as their interactions with cancer cells and other stromal components. In this review, we critically examine recent studies on TAMs in CCA, detailing the expression patterns and prognostic significance of different TAM subtypes in CCA, the mechanisms by which TAMs influence CCA progression and immune evasion, and the potential for reprogramming TAMs to enhance anticancer therapies. This review aims to provide a framework for deeper future research.
Based on promising preliminary data, the study will characterize the claim that PXR signaling serves as a key mechanistic link between the host environment and the innate immune system in the gut. It is widely believed that one cause of IBD stems from abnormal sensing of commensal bacteria. The research will shed light on the molecular mechanisms used by gut barrier epithelial cells in sensing commensals and regulating inflammatory responses in the gut. This will provide a new mechanism towards which more mechanisms derived probiotics could be used to abrogate intestinal inflammation. It is hoped that these agents would eventually serve as non-toxic alternatives or adjuncts to currently available therapeutics for IBD. The research protocol will involve the collection of feces, either by self-collection or through colonoscopic washing.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely physiotherapy. A method involves the administration of chophytol, diet therapy, magnetic therapy and exposure to electric current. The magnetic therapy is performed by a low-frequency sinusoidal alternating magnetic field. The exposure covers a collar zone and liver for 10-15 minutes. A continuous mode, frequency 50 Hz, grade I-II magentic induction are specified. The magnetic therapy is immediately followed by the exposure to complex-modulated pulse electric current with a neural-like pulse shape. The exposure is generated at the level Th- Th, paravertebrally to the right, and cover skin projections within the liver and gallbladder transversally. For this purpose, the electrodes are placed in 6 procedure fields: 1 - paravertebrally to the right at the level of the Thspine, 2 - paravertebrally to the right at the level of the Thspine, 3 - in a projection of the liver on a front surface of the body, 4 - in a projection of the liver on a back surface of the body, 5 - in a projection of the gallbladder on the front surface of the body, 6 - in a projection of the gallbladder on the back surface of the body. The 1and 2electrodes are connected to the channel IV, while the 3and 4electrodes - to the channel I, and the 5and 6electrodes are connected to the channel II. The channels I, II work in a frequency-drift group mode. The channel IV work in a continuous mode at fixed frequency 20 Hz. The current intensity is adjusted to apparent vibration sensation. Duration of a session is 10-15 minutes. The therapeutic course is 10-12 daily procedures.EFFECT: method improves the motor function of the gall bladder ensured by the improved cholekinesis, hepatic circulation and cholestasis elimination.2 ex, 3 tbl
Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. Anabolic androgenic steroid abuse can lead to serious cardiovascular and psychiatric adverse reactions [see Drug Abuse and Dependence (9)].   
If testosterone abuse is suspected, check serum testosterone concentrations to ensure they are within therapeutic range. However, testosterone levels may be in the normal or subnormal range in men abusing synthetic testosterone derivatives. Counsel patients concerning the serious adverse reactions associated with abuse of testosterone and anabolic androgenic steroids. Conversely, consider the possibility of testosterone and anabolic androgenic steroid abuse in suspected patients who present with serious cardiovascular or psychiatric adverse events.
Inflammation serves as a common characteristic across a wide range of diseases and plays a vital role in maintaining homeostasis. Inflammation can lead to tissue damage and the onset of inflammatory diseases. Although significant progress is made in anti-inflammation in recent years, the current clinical approaches mainly rely on the systemic administration of corticosteroids and antibiotics, which only provide short-term relief. Recently, immunomodulatory approaches have emerged as promising strategies for facilitating the resolution of inflammation. Especially, the advanced nanosystems with unique biocompatibility and multifunctionality have provided an ideal platform for immunomodulation. In this review, the pathophysiology of inflammation and current therapeutic strategies are summarized. It is mainly focused on the nanomedicines that modulate the inflammatory signaling pathways, inflammatory cells, oxidative stress, and inflammation targeting. Finally, the challenges and opportunities of nanomaterials in addressing inflammation are also discussed. The nanotechnology-mediated immunomodulation will open a new treatment strategy for inflammation therapy.
This responds to NHTSA's request with a proposal to increase our understanding of smoked cannabis' (CNB's) acute effects on cognition and simulated driving performance, the persistence of these deficits over the hours after use, and the influence of prior experience with CNB on these effects. The project also will link an extensive literature on CNB's effects on laboratory cognitive tests to simulated driving performance for the first time, providing a crucial validation of CNB's neurofunctional effects identifying maximally relevant candidate measures for field sobriety tests. To this goal, the proposed study was based upon a careful and thorough review of the scientific literature describing CNB effects on cognitive test performance and driving, as well as current state-of-knowledge on the sensitivity of biological assays for identifying recent CNB use. The study will carefully characterize the persistence of CNB's acute effects on cognitive test performance and driving over a several-hour time span. This will allow us to identify the point at which any effects of CNB intoxication on cognitive tests and driving performance cannot be distinguished from normal, i.e., the first step towards establishing standards for legal and social policy. The data obtained from simulated driving, cognitive tests, and biological assays of THC will be used in analyses aimed at identifying what tests or combination of tests predict both recent use and driving impairment risk.

Participants
Aging is the main risk factor for chronic lung diseases (CLDs) including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Accordingly, hallmarks of aging like cellular senescence are increased in these patients in different lung cell types including fibroblasts. However, little is known about the different triggers that induce a senescence phenotype in different disease backgrounds and its role in CLD pathogenesis. Therefore, we characterized senescence in primary human lung fibroblasts (phLF) from control, IPF, or COPD patients at baseline and after exposure to disease-relevant insults (H2O2, bleomycin, TGF-β1) and studied their capacity to support progenitor cell potential in a lung organoid model. Bulk-RNA sequencing revealed that phLF from IPF and COPD activate different transcriptional programs but share a similar senescence phenotype at baseline. Moreover, H2O2 and bleomycin but not TGF-β1 induced senescence in phLF from different disease origins. Exposure to different triggers resulted in distinct senescence programs in phLF characterized by different SASP profiles. Finally, co-culture with bleomycin- and H2O2-treated phLF reduced the progenitor cell potential of alveolar epithelial progenitor cells. In conclusion, phLF from COPD and IPF share a conserved senescence response that varies depending on the insult and impairs alveolar epithelial progenitor capacity ex vivo.
PURPOSE:To obtain a new subject compound having tachykinin antagonism and effective in treatment and prevention for tachykinin-intercalated diseases such as asthma, atopic dermatitis and nettle rash, by culturing a specific microorganism belonging to the genus Aspergillus. CONSTITUTION:A microorganism belonging to the genus Aspergillus and having ability capable of producing a compound (TAN-1666A) expressed by formula I or a compound (TAN-1666B) expressed by formula II [e.g. Aspergillus terreus FL-29694 (FERM P-13126), etc.] is inoculated into a culture medium and subjected to shake culture at 28 deg.C for 48hr to afford a seed culture. The seed culture is transplanted to a culture medium in a stainless-steel tank and subjected to spinner culture under aeration at 24 deg.C and then, pH of culture medium is adjusted to pH 2-4 and the cultured mixture is extracted with dichloromethane, etc., and the extracted liquid is extracted with a dilute alkali water. Thereby, TAN-1666B is dissolved in a water layer and TAN-1666A is left in an organic solvent layer and these layers are purified to provide the objective TAN-1666 related compound expressed by formula III [R1 is H; R2 is (substituted)alkoxy, etc., or R2 forms direct bond together with R1].
Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo liver surgery on day 1 of week 7. Beginning 4 weeks after surgery, patients continue nivolumab IV over 30 minutes every 4 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity.
The prevalence of childhood metabolic syndrome is rising with an increase in obesity. The current confirmatory diagnostic methods for metabolic syndrome are invasive. Triceps Skinfold Thickness (TSFT) measurement is a non-invasive alternative. This cross-sectional study evaluated the performance of TSFT for screening overweight and obese adolescents aged 10-16 years for metabolic syndrome. Out of 60 participants, 17 (28%) had metabolic syndrome. The mean (SD) TSFT measurements were significantly higher in adolescents with metabolic syndrome compared to those without metabolic syndrome [29.4 (6.0) vs. 24.3 (7.6); P = 0.018]. A cutoff of 26.7 mm for TSFT demonstrated 88% sensitivity and 72% specificity in predicting metabolic syndrome. TSFT was found as promising non-invasive screening tool for metabolic syndrome.
The real group received biphasic rSMS using a Magstim Super Rapid (Magstim, Whitland, UK) stimulator connected to a 120-mm outer diameter figure-of-8 air film cooling coil positioned in the midline over the sacral vertebrae (approximately 5 cm above the natal cleft, which approximates to the level of S2). Stimulation was delivered at 15 Hz at 50% of maximum stimulator output (10 seconds on and 30 seconds off) with a total of 1500 pulses and the hand of the coil upward. The stimulation was repeated for 10 sessions, 5 sessions per week and 2 days off.
Although clinically effective, the manufacturing process of first generation PCB coatings contributed to inconsistent drug concentrations, particulate formations on the balloon surface and their shedding during the interventional procedures. As a consequence developments of new PCB coatings have been proposed to address consistency, uniformity, small particle drug coverage, which may potentially contribute to improved vessel healing profile and improved clinical outcomes. Nevertheless, data on the safety and efficacy of this novel coating developments in the clinical setting remain limited. Previously in the experimental model, the investigators reported that delivery of paclitaxel via a novel mcPCB resulted in low long-term tissue retention of paclitaxel, however displayed reduced neointimal proliferation and favorable healing profile. Therefore in current clinical trial the investigators will address the feasibility and safety of the mcPCB (PAK, Balton) in the treatment of femoropopliteal restenotic disease in a prospective, randomized manner when compared to plain balloon angioplasty (PBA). The efficacy analysis will be observational and evaluated post-hoc, with no prespecified criteria.
PURPOSE: To provide a well differentiate, structurized, and homogenized skin substitute by mixing contractile cells with trophic medium to form gel, eliminating the trophic medium to form a corium substitute, transplanting a fragment of trichocyst on the corium substitute, and putting it to get in contact with keratin-synthesizing cells. CONSTITUTION: Hair enclosed by a tegument 21 is pulled, it is cut in a zone where it is enclosed in the tegument 21 perpendicularly to a center length direction line, and a transplantation body 22 is formed. A fraction of skin organization including corium 4 and epidermis 3 is arranged in a plate disposed in culture medium. As the result of mutual action between fibroblast as contracting cells and collagen fibers included in trophic media in gel, the volume of the gel is decreased, the trophic medium is eliminated, and a corium substitute 24 is formed. The transplantation body 22 is inserted from a free surface of the gel perpendicularly to the center length direction line in initial several minutes of gel contraction. After insertion for transplantation, the corium substitute 24 is immersed in trophic medium (MN1) 25 for 5-6 days.  Move of keratin-synthesizing cells forms an epidermis substitute 26 on the corium substitute 24, thereby a skin substitute 27 is formed of the corium substitute 24 and the epidermis substitute 26.
Participants are exposed to 31°C and 45% relative humidity for 8 hours. These conditions are similar to mean domicile conditions measured in a variety of domicile types during heat waves complexes during heatwaves and are consistent with the World Heath Organization recommendation for maximal indoor temperatures.
To provide a pyridone compound that is excellent in pest control activity, particularly, insecticidal activity and/or acaricidal activity; is excellent in safety; and can be synthesized in an industrially advantageous manner.SOLUTION: This invention relates to a compound represented by the following formula or a salt thereof. Ris a C1-6 alkyl group. Ris a substituted or unsubstituted C1-6 alkyl group, a substituted or unsubstituted C2-6 alkenyl group or the like. Z is an oxygen atom or a sulfur atom. n is an integer selected from 0-2. Q is a directly-bonded 5-6 condensed-ring.SELECTED DRAWING: None
A radio-active aqueous bath for toilet or hygienic purposes is obtained by treating the bath with a halogen, or a substance yielding halogen under the conditions together with an organic substance, soluble in water to give a solution permeable by light rays, and unstable in the presence of halogen and water. Suitable halogen yielding substances are chloramine T with or without potassium iodide, and suitable organic substances are carbohydrates such as glucose and they may be mixed together to form a convenient preparation for addition to a bath or added thereto separately. Substances such as borax or carbonate of soda, as water softeners, and any suitable scent imparting substance may be added. Specification 320,096, [Class 81 (i)], is referred to.ALSO:A radio-active aqueous bath for toilet or hygienic purposes is obtained by treating the bath with a halogen or a substance yielding halogen under the conditions, together with an organic substance, soluble in water to give a solution permeable by light-rays, and unstable in the presence of halogen and water. Suitable halogen yielding substances are chloramine T with or without potassium iodide, and suitable organic substances are carbohydrates such as glucose and they may be mixed together to form a convenient preparation for addition to a bath or added thereto separately.  Substances such as borax or carbonate of soda, as water softeners, and any suitable scent imparting substance may be added.  Specification 320,096, [Class 81 (i)], is referred to.
Phase 1 of CDT will be applied to CDT group. This application consists of manual lymph drainage, skin care, compression bandage and exercises. This phase will continue 5 days a week for 3 weeks.
Powders having contact biocidal properties comprise a polysacharide carrying atomic/metallic silver. The preferred polysaccharide is chitin, although other polysaccharides including chitosan, carboxymethyl celluloses and carrageenans can be used. The chitin may be obtained from deproteinated crustacean shells without demineralisation, thus being admixed with calcium carbonate and other naturally occurring minerals present in the shells, and may be enzyme deacetylated. The powders of the invention can be used as biocidal dusting powders, formulated into pastes, gels, hydrogels, creams, foams and aerosol sprays for pharmaceutical applications, or dissolved to form solutions for coating substrates such as skin, fabrics, glass, leather and paper to give a bactericidal surface. A particular application of such a solution is as a protective, post-wash treatment for workwear in a laundering process. The powders of the invention may be prepared by slurrying a polysaccharide, which is capable of interacting with silver ions and which is in powder form, in a liquid in which the polymer is insoluble, which liquid contains silver ions, filtering off the powder, washing the powder, reducing the silver ions which have interacted with the polysaccharide to atomic/metallic silver, and drying the powder. According to the polysaccharide chosen, the liquid is suitably water or aqueous ethanol. The silver ions may derive from silver nitrate. The reduction of the silver ions which have interacted with the polysaccharide to atomic/metallic silver can be effected photochemically through exposure to light. To hasten the reduction, however, the washed powder is preferably slurried in a solution of an alkali metal halide, irradiated under stirring with natural or artificial light containing an ultraviolet component, and again filtered off and washed, before drying it.
1. Apply 0.1 mL of the technetium Tc 99m mertiatide preparation to the head of the cartridge through the longer end of the cartridge using a 1 mL syringe with needle.  
Note: The cartridge and all solutions eluted from it will be radioactive after this step. 
  2. With a disposable 10 mL syringe, slowly push 10 mL of 0.001N hydrochloric acid through the cartridge. Collect this fraction in a culture tube or vial for counting. 
  3. Similarly, elute the cartridge with 10 mL of the 1:1 ethanol/saline solution. Be sure that this solution is pushed through the cartridge slowly so that the elution occurs in a drop-wise manner. Collect this 10 mL fraction in a second culture tube or vial for counting. 
  4. Place the Sep-Pak cartridge in a third culture tube or vial for counting.
Cetuximab will be administered weekly as an i.v. infusion. Irinotecan will be administered as an i.v. infusion on Weeks 1 and 2 and repeated every 3 weeks.
Participants will be given 2 weeks of placebo treatment. The placebo capsules will be taken once a day orally. The daily dose of placebo treatment will match the Prednisone dose for each participant.
The invention provides an application of Del-1 protein in preparing a medicament for treating secondary injury after craniocerebral trauma, and belongs to the technical field of medical application. The Del-1 protein can not only remove pathological microvesicles in peripheral blood to prevent and treat TBI post-coagulopathy, but also stabilize vascular endothelial cells in the treatment of craniocerebral Trauma (TBI), thus achieving the effect of preventing blood brain barrier leakage and cerebral edema after TBI. And the Del-1 protein is a protein secreted normally in human body, so that the safety and the practicability are good. Can be used for preparing medicaments for treating secondary injury after trauma. Since the Del-1 protein can be obtained from human endothelial cells, it can also be obtained in large quantities by in vitro cell culture expression. The protein can also play a role in stabilizing endothelial cells, and has more remarkable function in treating endothelial disorders.
BACKGROUND: We explore the spatial distribution of comorbidity with trachoma and potentially visual-impairing non-communicable diseases (NCDs) and their risk factors among Kenyan pastoralists.
METHODS: Using a cross-sectional study design, we recruited and clinically examined 262 study participants for NCDs (hypertension or diabetes) and trachoma using the World Health Organization grading system. Network models estimated interactions and risks linked with trachoma and NCDs while the Poisson point process determined their spatial distribution.
RESULTS: Of the 262 participants, 140 (53%) had trachoma, with >71% of these cases identified among females and those >60 y of age. A total of 36 trachoma cases co-occurred with hypertension (26%) and diabetes (0.01%). NCDs were frequent among those with recurring trachoma (21%) and trachomatous trichiasis (14.3%). Trachoma and NCDs clustered together in <1 km distances (R=0.18, p=0.02). In network analysis, age was strongly associated with trachoma and NCDs. Trachoma was linked with geographic location while diabetes was linked with water source distances. Education level became the central risk factor.
CONCLUSIONS: We demonstrate a twin trachoma-NCD burden that is higher among elderly pastoralists in southern Kenya. Attenuating adverse population-level visual impairment, including integrating the trachoma SAFE strategy with NCD comprehensive care, amplifies the benefits from economies of scale, accelerating realization of Sustainable Development Goal 3 and universal health coverage in hard-to-reach areas.
Patients also undergo HA-WBRT QD for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients will also receive memantine PO QD or BID for up to 24 weeks in the absence of disease progression or unacceptable toxicity.