anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
(see also Boxed WARNING) 

The total combined duration of use of oral ketorolac tromethamine and intravenous or intramuscular dosing of ketorolac tromethamine is not to exceed 5 days in adults. Ketorolac tromethamine is not indicated for use in pediatric patients.

The most serious risks associated with ketorolac tromethamine are:

  * Gastrointestinal Effects - Risk of Ulceration, Bleeding, and Perforation:Ketorolac tromethamine is contraindicated in patients with previously documented peptic ulcers and/or gastrointestinal (GI) bleeding. Ketorolac tromethamine can cause serious GI adverse events including bleeding, ulceration and perforation, of the stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with ketorolac tromethamine. 




Only one in five patients who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Minor upper gastrointestinal problems, such as dyspepsia, are common and may also occur at any time during NSAID therapy.

The incidence and severity of gastrointestinal complications increases with increasing dose of, and duration of treatment with ketorolac tromethamine. Do not use ketorolac tromethamine for more than five days.

However, even short-term therapy is not without risk. In addition to past history of ulcer disease, other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids, or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this population.

To minimize the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration.Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected. This should include discontinuation of ketorolac tromethamine until a serious GI adverse event is ruled out. For high risk patients, alternate therapies that do not involve NSAIDs should be considered. 

NSAIDs should be given with care to patients with a history of inflammatory bowel disease (ulcerative colitis, Crohn's disease) as their condition may be exacerbated.
BACKGROUND: Children with ADHD were found to have language impairment in many studies. The way they use language in their everyday life may be affected, namely, the pragmatic aspect of language. Measuring the affected parameters in all aspects of language will help to reach better rehabilitation. Thus, this study set out to observe relationships between hyperactivity/impulsivity and inattention with all language domains in 30 Egyptian Arabic-speaking children with ADHD between 4 and ≤7 years old with the aim of better intervention. Children were evaluated to establish the diagnosis of ADHD and its type following the diagnostic criteria of the DSM-V criteria and the Conners' Parent Rating Scale-Revised. Language abilities were assessed by the Pre-school Language Scale 4th edition (Arabic version), the Arabic articulation test, and the Egyptian Arabic Pragmatic Language Test. This assessment covered receptive and expressive language abilities and phonological and pragmatic skills.
RESULTS: Compared to norms, it was found that the ADHD children who participated in this study had non-significant language delays in the parameters of the modified PLS-4 test. 70 % of the ADHD children had total pragmatic test scores below their 5th percentile, while 30 % of the children had total pragmatic test scores above their 5th percentile. 50 % of ADHD children failed to master certain sounds corresponding to their phonological age. A statistically significant negative correlation was observed between each of the inattention and hyperactivity/impulsivity scores and the receptive, expressive, total language ages, and pragmatic language scores.
CONCLUSION: Children with ADHD in this study did not show major difficulties in areas beyond what would be expected in normally developing children. Most children with ADHD in the present study had problems with pragmatic language aspects that are correlated positively to ADHD symptoms. 50 % of ADHD children failed to master certain sounds corresponding to their chronological age.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to synthetic biologically active compounds of class belonging to derivatives of 1-deoxy-1-N-methylaminohexaalcohols and N-acridone acetic acid. Invention describes new compounds - salts of 1-deoxy-1-N-methylaminohexaalcohols with N-acridone acetic acid of the general formula (I)   showing an immunomodulating activity. Invention describes also a drug showing an immunomodulating activity characterized in that it contains the compound of the formula (I). EFFECT: enhanced immunomodulating activity of compounds. 2 cl, 3 tbl, 5 ex
CC-4047 0.5 mg orally daily starting on day 1 through 28. Prednisone given during first 3 cycles of therapy. It will be dosed orally at the dose of 30 mg/day during cycle 1, 15 mg/day during cycle 2, and 15 mg every other day during cycle 3, and then it will be discontinued.
Optic nerve sheath diameter (ONSD) was detected 3 mm behind the entry point of the optic nerve into the globe in both eyes in each ultrasonographic measurement. ONSD was measured bilaterally 3 mm posterior to the papilla. Transverse measurements were made for each optic nerve.
The present invention provides medical composition for treating tinea pedis and tinea corporis, which belongs to the technical field of the combination of Chinese medicines and western medicines. The present invention is composed of the components of the following weight proportion: 2 to 4 parts of cinnabar, 5 to 9 parts of borneol, 4 to 9 parts of borax, 4 to 20 parts of sulfamethoxazole, 0.8 to 4 parts of trimethoprim, 3 to 18 parts of aspirin and 2 to 8 parts of mycostatin, wherein the borax needs to be calcined and fried. The components are ground into fine powder with the prior art and uniformly mixed into a powder agent, or 15 to 35 parts of white vaseline is added into the obtained powder agent to be uniformly mixed and prepared into paste, and the paste can be smeared to the affect parts. Compared with the prior art, the medical composition for treating tinea pedis and tinea corporis of the present invention has the advantages of reasonable medicine compounding, simple preparation technology, convenient use and favorable therapeutic effect. Besides, the present invention can effectively adjust sole qi and blood balance, and kill fungi. As a result, the present invention achieves the purpose of treating manifestation and nosogenesis.
PURPOSE:To obtain a new subject compound capable of solubilizing calcium phosphate and useful as a calcium enhancer having high rate of absorption by binding a phosphoric acid ester of a reducing sugar to a protein by aminocarbonyl reaction to introduce a phosphoric acid group into the protein. CONSTITUTION:A phosphoric acid ester of a reducing sugar (e.g. glucose-6-phosphoric acid) and a protein (e.g. whey protein) are dissolved in distilled water and pH of the solution is controlled to 7.5 by 1N NaOH and the solution is subjected to freeze-drying to afford powder, which is then retained at 50 deg.C and 65% relative humidity for 12hr to carry out aminocarbonyl reaction, and after finishing the reaction, the reaction mixture is dialyzed against distilled water to remove unreacted material and lyophilized. The residue is treated so as to introduce a phosphoric acid group into the protein to provide the objective phosphorylated protein compound capable of solubilizing calcium phosphate. Furthermore, 0.2M calcium chloride, 0.2M dipotassium hydrogen phosphate and citric acid, etc., are dropped to the phosphorylated protein compound wile retaining pH of the solution to 6.7 to provide the objective protein- calcium complex compound in which calcium is dissolved without producing any precipitate.
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to method of treatment of diseases that can be relieved by inhibition of tyrosine kinase receptor VEGF or by inhibition of angiogenesis. Method involves administration of phthalazine derivatives of the formula (I)  , the novel phthalazine derivatives of the formula (I), pharmaceutical composition comprising thereof and method for preparing compounds of the formula (I). Invention enhances the effectiveness of treatment and realizes the novel therapeutic approach with respect to treatment and prophylaxis of diseases indicated above. EFFECT: valuable medicinal properties of compounds. 16 cl, 7 tbl
A 74-year-old woman with an implanted physiological DDD pacemaker visited our department complaining of palpitations due to atrial fibrillation (AF). Catheter ablation therapy for AF was scheduled. Preoperative multidetector computed tomography showed that the inferior pulmonary vein (PV) was a common trunk, and the left and right superior PVs branched from the center of the left atrial roof. In addition, mapping of the left atrium before AF ablation revealed no potential in either the inferior PV or common trunk. We performed left and right superior PV and posterior wall isolation. After ablation, AF was not observed on pacemaker recordings.
Only one group will be evaluated during the SALINE study. Everyone that meets the inclusion criteria of having a high risk for albuminuria is invited to participate. During participation, subjects are asked to collect one or more urine samples for albuminuria determination. If albuminuria is high (\>= 3,0 mg/mmol) subjects are invited for a visit. During the visit non-invasive measurements (BMI, PoC HbA1c, eGFR, blood pressure and heart rate) are taken to determine the cardiovascular risk. Furthermore, medication use is reviewed.
The theory of dopamine channels states that dopamine molecules pass through dopamine functional channels to reach dopamine active cavities to play a dopamine functional role. The science and pathology of Parkinson's disease states that Parkinson's disease occurs when dopamine functional pathways are blocked by fibrin. This is because occlusion of dopamine functional channels results in a decrease in dopamine-functional factors and a decrease in functional dopamine content. The ephedrine molecule is adopted, so that the function of specifically selecting a functional channel passing through dopamine is realized, and the application of the ephedrine in treating and controlling the Parkinson's disease is invented. Experimental determination proves that the ephedrine is a substance which has a specific selection to pass through a dopamine functional channel. The experiment of the mouse and the animal proves that the ephedrine can dredge the dopamine functional channel blocked by the +/-synuclein and has the effect of treating and controlling the Parkinson's disease.
PROBLEM TO BE SOLVED: To provide a method for control of fish parasites, especially white spot worms.SOLUTION: The present invention relates to a method for control of fish parasites, the method comprising administering a folic acid synthesis inhibitor and/or folate activation inhibitor to a fish continuously for one to two weeks in a daily dosage amount of 1 to 50 mg/kg of fish weight. A mixture of the folic acid synthesis inhibitor and the folate activation inhibitor is preferable. The folic acid synthesis inhibitor is preferably a sulfa drug. The folate activation inhibitor is preferably a dihydrofolate reductase inhibitor, a folic acid antagonist, or the like. The parasiticide concerned can control the fish parasites by oral administration. The method for control of fish parasites is effective particularly to parasites belonging to ciliates among fish parasites.SELECTED DRAWING: None
A woman with suspected preeclampsia and with inclusion criteria receives a blood sample, according to the department's usual practices, to analyse the values of sFlt-1 and PlGF and the usual vascular-renal sample. The woman gave her verbal consent to participate in the study. The Roche Elecsys® immunoassay sFlt-1/PlGF ratio was used to measure the two markers in the patients' blood.
A resveratrol and lauric polyether complex provided by the invention is a resveratrol-containing lauric polyether complex. The complex is composed of the following materials: lauric polyether, resveratrol and citric acid. Equipment used for complexation is a stainless steel (or enamel or glass) reaction vessel with reflux and heating functions. The complex is a light yellow viscous liquid in appearance and is soluble in water, ethanol, isopropanol and acetone. The pH value (1% aqueous solution) of the complex is 5-7; moisture of the complex is less than or equal to 1.0%; viscosity (25 DEG C CPS) of the complex is 1100-1300; and the content of resveratrol is 5-10%. The complex at an effective concentration has a good effect of sterilizing staphylococcus aureus, escherichia coli, fungus, mould and the like. The resveratrol and lauric polyether complex has good water solubility, can widely be applied in pharmaceuticals, food, cosmetic and human body cleaning products, and is an intermediate for preparation of medicines, health care products, cosmetics, pilatory, hair itching-relieving lotions, a face cleansing lotion and the like.
Cardiovascular (CV) morbidity and mortality are frequently occurring problems in chronic kidney disease (CKD) patients. Apart from the so called traditional risk factors, also risk factors more or less specific to CKD contribute in the pathogenesis of these problems. There is strong evidence that the sympathetic hyperactivity, which often characterizes CKD, is one such factor. Previously, we have shown that angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) reduce but not normalize this sympathetic hyperactivity. We re-analysed the cohort of patients who were investigated in the past and subsequently treated according to present guidelines. The results show that, despite of treatment, the unfavourable relation between sympathetic hyperactivity and clinical outcome still exits. This might mean that treatment is insufficient. In present study, we want to study the effect of Aliskiren 300mg on sympathetic nerve activity.
BACKGROUNDS: Glioma is a highly aggressive type of brain tumor, and its prognosis is still poor despite recent progress in treatment strategies. G protein-coupled receptor 27 (GPR27) is a member of the G protein-coupled receptor family and has been reported to be involved in various cellular processes, including tumor progression. Nevertheless, the clinical potential and tumor-related role of GPR27 in glioma remain unknown. Here we aimed to explore the function and role of GPR27 in gliomas.
METHODS: In the current study, we evaluated the expression and clinical significance of GPR27 in gliomas using data from The Cancer Genome Atlas (TCGA) datasets. We also conducted cellular experiments to evaluate the functional role of GPR27 in glioma cell growth.
RESULTS: We found that GPR27 expression level was closely associated with disease status of glioma. Of note, GPR27 was negatively correlated with WHO grade, with grade IV samples showing the lowest GPR27 levels, while grade II samples showed the highest levels. Patients with IDH mutation or 1p/19q co-deletion exhibited higher GPR27 levels. In addition, lower GPR27 levels were correlated with higher death possibilities. In cellular experiments, we confirmed that GPR27 inhibited glioma cell growth.
CONCLUSIONS: Our results indicate that GPR27 may function as a potential prognostic biomarker and therapeutic target in gliomas. Further studies are needed to illustrate the signaling mechanism and clinical implications of GPR27 in gliomas.
Satisfaction with one's academic major is critical to a university student's development. This study explores the interrelationships among thinking styles, grit, and academic major satisfaction in both deaf or hard-of-hearing (DHH) and hearing students, employing independent samples t-tests to compare the two groups, Pearson's correlation analysis to explore relationships among the variables, and mediation analysis to understand the mediating effect of grit on the relationship between thinking styles and academic major satisfaction. The results indicated significantly higher levels of grit and consistency of interest in DHH students than hearing students, with no significant differences in perseverance of effort. A strong correlation was found between thinking styles and both grit and academic major satisfaction, particularly in DHH students. Mediation analysis revealed that grit significantly mediated the relationship between thinking styles and academic major satisfaction, underscoring its role in enhancing students' academic experience. These findings contribute to the limited literature on DHH students' psychological attributes and the complex interplay of psychological constructs in academic major satisfaction, offering valuable insights for tailored educational strategies.
This group of patients underwent catheterization after anesthesia,and the catheter was indwelled. The patient was routinely removed for 24 to 72 hours after surgery.
There are 2 groups: active drug and placebo. The patients in the placebo arm receive an administration of eyedrops to the affected eye, identical to the active drug but with no thymosin beta 4 (0.00% thymosin beta 4, w/w), 2 drops 4 times a day (breakfast, lunch, dinner, and bedtime) for 14 days. The first of 4 daily doses will be administered following surgery (vitrectomy).
Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness and impaired performance caused by insufficient sleep. It is unclear (1) whether daily use of caffeine could prevent or exacerbate the GM alterations induced by 5-day sleep restriction (i.e. chronic sleep restriction, CSR), and (2) whether the potential impact on GM plasticity depends on individual differences in the availability of adenosine receptors, which are involved in mediating effects of caffeine on sleep and waking function. Thirty-six healthy adults participated in this double-blind, randomized, controlled study (age = 28.9 ± 5.2 y/; F:M = 15:21; habitual level of caffeine intake < 450 mg; 29 homozygous C/C allele carriers of rs5751876 of ADORA2A, an A2A adenosine receptor gene variant). Each participant underwent a 9-day laboratory visit consisting of one adaptation day, 2 baseline days (BL), 5-day sleep restriction (5 h time-in-bed), and a recovery day (REC) after an 8-h sleep opportunity. Nineteen participants received 300 mg caffeine in coffee through the 5 days of CSR (CAFF group), while 17 matched participants received decaffeinated coffee (DECAF group). We examined GM changes on the 2nd BL Day, 5th CSR Day, and REC Day using magnetic resonance imaging and voxel-based morphometry. Moreover, we used positron emission tomography with [18F]-CPFPX to quantify the baseline availability of A1 adenosine receptors (A1R) and its relation to the GM plasticity. The results from the voxel-wise multimodal whole-brain analysis on the Jacobian-modulated T1-weighted images controlled for variances of cerebral blood flow indicated a significant interaction effect between caffeine and CSR in four brain regions: (a) right temporal-occipital region, (b) right dorsomedial prefrontal cortex (DmPFC), (c) left dorsolateral prefrontal cortex (DLPFC), and (d) right thalamus. The post-hoc analyses on the signal intensity of these GM clusters indicated that, compared to BL, GM on the CSR day was increased in the DECAF group in all clusters  but decreased in the thalamus, DmPFC, and DLPFC in the CAFF group. Furthermore, lower baseline subcortical A1R availability predicted a larger GM reduction in the CAFF group after CSR of all brain regions except for the thalamus. In conclusion, our data suggest an adaptive GM upregulation after 5-day CSR, while concomitant use of caffeine instead leads to a GM reduction. The lack of consistent association with individual A1R availability may suggest that CSR and caffeine affect thalamic GM plasticity predominantly by a different mechanism. Future studies on the role of adenosine A2A receptors in CSR-induced GM plasticity are warranted.
FIELD: medicine, pharmacy. SUBSTANCE: method involves the use of complex treatment in combination with ointment containing, wt.-%: alfalfa aqueous sterile extract 10; anhydrous lanolin 30; medicinal Vaseline 50 and water for injection 10 as a local medicinal preparation. Ointment is applied on the damaged site by uniform layer (one per a day for 5-15 days). Also, Eracond substance (0.5-1.0 g/24 h) or Eracond tablets (0.2 g in 1 tablet, three times per a day) were given to patient up to complete recovery. Method involves massage of site on which ointment was applied. EFFECT: enhanced antiinflammatory action, regeneration stimulation, enlarged assortment of phytotherapy agents.
PURPOSE OF REVIEW: Community engagement is key to the success of sustainable public health interventions. This review highlights recent published studies that describe the use of community-engaged methods in sexually transmitted infection (STI) prevention research.
RECENT FINDINGS: We organized the findings using a socio-ecological model. At the individual level, communities were engaged through participation in formative research, short-term consultations and community advisory board participation, as well as co-creation activities. At the interpersonal level, studies reviewed described peer-led interventions that leverage the influence and guidance of peers, patient-led interventions in the form of patient navigation and notification, as well as those that mobilize social networks and the power of social relationships to promote health. At the organizational and community level, multisectoral, multifacility collaborations between community, government, and academic stakeholders were highlighted. At the policy and population level, communities were engaged through community dialogues to disseminate research findings, as well as in developing strategic frameworks and clinical guidelines. Digital tools have also been leveraged for effective community engagement.
SUMMARY: Communities have an effective role to play in STI prevention and can be engaged at multiple levels. Future efforts may consider the use of community engagement tools highlighted in this review, including digital technologies that have the potential to reach more diverse end-users.