anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Introduction: Sleep is one of the most significant parts of everyone's life. Most people sleep for about one-third of their lives. Sleep disorders negatively impact the quality of life. Obstructive sleep apnea (OSA) is a severe sleep disorder that significantly impacts the patient's life and their family members. This study aimed to investigate the relationship between rs6313 and rs6311 polymorphisms in the serotonin receptor type 2A gene and OSA in the Kurdish population. Materials and Methods: The study's population comprises 100 OSA sufferers and 100 healthy people. Polysomnography diagnostic tests were done on both the patient and control groups. The polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) was used to investigate the relationship between OSA and LEPR gene polymorphisms. Results: Statistical analysis showed a significant relationship between genotype frequencies of patient and control groups of rs6311 with OSA in dominant [odds ratio (OR) = 5.203, p < 0.001) and codominant models (OR = 9.7, p < 0.001). Also, there was a significant relationship between genotype frequencies of patient and control groups of rs6313 with OSA in dominant (OR = 10.565, p < 0.001) and codominant models (OR = 5.938, p < 0.001). Conclusions: Findings from the study demonstrated that the two polymorphisms rs6311 and rs6313 could be effective at causing OSA; however, there was no correlation between the severity of the disease and either of the two polymorphisms.
FIELD: veterinary, food production. SUBSTANCE: active substance of premix is polyelectrolyte complex of cation polyelectrolyte and anion detergent; filling agent is taken from the order involving wheat bran, milled wheat or barley, irradiated food yeast, zeolite. Also, premix has mineral salts of macroelements (magnesium) and trace elements (zinc, cobalt, manganese, copper, iodine), vitamins (U, E, A, D) and phosphorus-containing additional food. Combined fodders contain the obtained premixes. Prophylaxis of metabolism disorders and curative effect at severe metabolism damages (hepatodystrophy) were provided after combined fodders feeding to calves at doses 1-5 kg/100 kg living mass/24 hr. EFFECT: enhanced effectiveness of agent.
Participants in the waitlist control group will receive materials on the promotion of physical and psychological health during the waiting period. Participants will then receive the same 24-week intervention as the experimental group in Week 25 after completing the baseline assessment.
The REDUCTION trial is a prospective multicentre cohort study conducted at the level I emergency departments of the University Medical Center Groningen, Isala hospital (Zwolle, The Netherlands) and the level II trauma center Nij Smellinghe hospital (Drachten, The Netherlands). The increased availability of Computed Tomography (CT) in the emergency department is leading to an overuse for patients with suspected maxillofacial injury. The use of a clinical decision aid could lead to more expedient use of diagnostic imaging within this population of patients. Therefore, all maxillofacial trauma patients admitted to the emergency department are included in this trial if the consultation is within 7 days after trauma. Both maxillofacial trauma patients admitted to CT scan and patients without a radiological confirmed diagnosis are included. The research protocol was approved by the institutional review board of the University Medical Center Groningen (Groningen, The Netherlands). Informed consent was waived as patients are treated according to the standards of care. Upon admission, each patient with maxillofacial injury will be allocated as a midfacial or mandibular trauma. During physical examination, either by the emergency physician or surgical resident, a pre-defined selection of clinical parameters will be assessed focussing on the assessment of potential presence of fractures in the maxillofacial region. The standardization of this examination will be ensured using a pocket map and easy accessible online instructional video's. The clinical parameters, fracture likelihood and physical examination findings will be structurally reported in electronic health record software using a smart tool dedicated for maxillofacial injury. Data regarding patient demographics, mechanism of injury, concomitant injury, diagnostic outcome and radiation dose parameters will be derived from the medical records.
The present invention relates to a health product and a preparation method thereof. The health product with the functions of weight reduction and beauty treatment contains raw materials of the following parts by weight: 5 to 15 parts of cassia seeds, 5 to 12 parts of haws, 2 to 6 parts of wolfberry fruits, 5 to 12 parts of poria and 5 to 14 parts of rice beans, and is prepared by the steps of treatment of raw materials and processing. The health product of the present invention has the advantages of reasonable matching and obvious action effects. After the Chinese herbal medicines are matched, the health product has the functions of absorbing human body surplus fat, nourishing a stomach and strengthening a spleen. In practical use, a person taking the health product of the present invention has normal diet, the intake of desserts is reduced, but slimming is not needed. The health product can be drunk by the person with an empty stomach once every day and 400 ml for each time, and a good amount of sweat is exhausted in the period of the person drinking the health product. With the extension of the drinking time, the sweat is reduced, and the weight of the person is kept to be normal. Through observation after stopping drinking the health product, the body weight can not gain for as long as 10 years maximally. The health product has an especially obvious effect on teenagers and females with adiposity.
Inflammatory bowel disease (IBD) treatment was revolutionised with the arrival of biological therapy two decades ago. There are now multiple biologics and increasingly novel small molecules licensed for the treatment of IBD. Treatment guidelines highlight the need for effective control of inflammation and early escalation to advanced therapies to avoid long-term complications. Consequently, a large proportion of patients with IBD receive advanced therapies for a long time. Despite their beneficial risk-benefit profile, these treatments are not without risk of side effects, are costly to healthcare providers and pose a burden to the patient. It is, therefore, paramount to examine in which circumstances a temporary cessation of therapy can be attempted without undue clinical risk. Some patients may benefit from cyclical rather than continuous treatment. This review examines the risk of relapse after discontinuation of advanced therapies, how to identify patients at the lowest risk of relapse and the chance of recapturing response when flaring after discontinuation.
Psycho-education video + an active placebo training, consisting of 10 sessions of ±15 minutes each (during an intervention period of two weeks), will be administered. The training task is an undirected scrambled sentences task with online contingent feedback.
OBJECTIVE: In our study, we aim to explore the structural differences between the aortic root and the pulmonary artery to better understand the process of pulmonary autograft dilatation during the Ross procedure.
MATERIALS AND METHODS: We studied twenty human fetuses (aged 14-36 weeks of gestation) and four adults (one female and three males, aged 30-45 years, mean age = 37 ± 16 years). Samples of aortic root and pulmonary artery were obtained through dissection. Histological examinations, including hematoxylin-eosin, Masson's trichrome, and orcein staining, as well as immunohistochemical technique with caldesmon staining, were performed. Microscopic counting was conducted to assess the number of elastic laminae and smooth muscle cells in each arterial wall. Statistical analyses were performed using R software. Means and standard deviations were used to present central tendencies and data dispersion for elastic laminae and smooth muscle.
RESULTS: Significant histological differences were observed between the aortic root and pulmonary artery in both adults and fetuses. In fetuses, no difference was found between the two vessels in terms of elastic laminae (p = 0.26) and smooth muscle cells (p = 0.69). However, in adults, significant differences were found for elastic laminae (p < 0.001) and smooth muscle cells (p < 0.001) between the aorta and pulmonary artery.
CONCLUSIONS: The microscopic vascular structure impacts the mechanical properties of the pulmonary autograft wall and explains its observed dilatation remote from the Ross procedure due to wall stresses related to systemic pressure.
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is caused by biallelic pathogenic expansions, or compound heterozygosity with other pathogenic variants in the RFC1 gene. CANVAS is estimated to be underdiagnosed, both because of the lack of formal diagnostic criteria and molecular challenges that translate to lesser access and high cost of routine testing. Our aim was to address the need for making CANVAS genetic testing routine, by designing a streamlined two-step PCR consisting of a short-allele screening PCR and a confirmatory PCR with fragment capillary electrophoresis detection. Exome sequencing of RFC1 was additionally foreseen to resolve potential compound heterozygosity cases. Specificity of our approach was evaluated using ataxia patients with known non-CANVAS diagnoses, and optimized using Southern blot confirmed CANVAS patients. We evaluated our approach by testing patients consecutively referred for clinically suspected CANVAS using first the two-step PCR, followed by exome sequencing. Our approach was able to accurately identify negative and confirm positive cases in prospectively collected suspected CANVAS patients presenting with at least three typical clinical signs. The proposed testing approach provides an alternative method able to clearly distinguish between CANVAS negative and positive cases and can be easily incorporated into the genetic diagnostic laboratory workflow.
The recipient will begin a lymphodepleting preparative regimen of fludarabine and cyclophosphamide on Day -6. The haploidentical donor identified by HLA matching of the immediate family members will undergo non-mobilized large volume (20-L) leukapheresis on Day -1, and the NK cell product will be infused into the recipient on Day 0. Subcutaneous IL-2 will begin approximately 2-4 hours after infusion and will continue every other day through Day 12 for a total of 7 doses.
This study investigated the time course of gene expression changes during the progression of persistent painful neuropathy caused by paclitaxel (PTX) in male and female mouse hindpaws and dorsal root ganglia (DRG). Bulk RNA-seq was used to examine these gene expression changes at 1, 16, and 31 days post-last PTX. At these time points, differentially expressed genes (DEGs) were predominantly related to the reduction or increase in epithelial, skin, bone, and muscle development and to angiogenesis, myelination, axonogenesis, and neurogenesis. These processes are accompanied by the regulation of DEGs related to the cytoskeleton, extracellular matrix organization, and cellular energy production. This gene plasticity during the progression of persistent painful neuropathy could be interpreted as a biological process linked to tissue regeneration/degeneration. In contrast, gene plasticity related to immune processes was minimal at 1-31 days after PTX. It was also noted that despite similarities in biological processes and pain chronicity between males and females, specific DEGs differed dramatically according to sex. The main conclusions of this study are that gene expression plasticity in hindpaw and DRG during PTX neuropathy progression similar to tissue regeneration and degeneration, minimally affects immune system processes and is heavily sex-dependent at the individual gene level.
PURPOSE: To report a rare case of cytomegalovirus (CMV)-associated non-necrotizing viral retinopathy, occlusive retinal vasculitis, papillitis, and retinal neovascularization in a young 41-year-old woman.
METHODS: Case report.
RESULTS: The patient presented with features of papillitis, peripapillary cotton-wool spots, pre-retinal hemorrhages, and occlusive vasculitis. Her visual acuity was 20/100 in the left eye. She developed a worsening of the disease upon initiation of systemic corticosteroids. Her serum immunoglobulins (Ig) (both IgG and IgM) were highly positive for CMV. Anterior chamber paracentesis was positive for CMV DNA using real-time polymerase chain reaction. After stopping systemic corticosteroids, she was initiated on oral valganciclovir, with rapid resolution of the vasculitis and cotton-wool spots. After three months, the patient developed retinal neovascularization and underwent pan-retinal photocoagulation. However, her uveitis was inactive, and her visual acuity improved to 20/25.
CONCLUSIONS: Non-necrotizing viral retinopathy has been associated with either varicella zoster virus (VZV) or herpes simplex virus (HSV). Our case highlights that CMV can also lead to non-necrotizing retinopathy and must be suspected in patients who may be negative for VZV and HSV. Appropriate anti-viral treatment can prevent severe vision loss in these patients.
Diabetic nephropathy represents one of the main long-term complications in T2DM patients. Cigarette smoking represents one of modifiable renal risk factors to kidney damage due to lead (Pb) exposure in these patients. Our goal is to investigate serum copeptin and Kidney injury molecule-1 (KIM-1) and urinary lead (UPb) in type 2 diabetes mellitus (T2DM) patients even smokers and non-smokers groups and compared to corresponding health controls and assess its associations with Angiotensin-Converting enzyme Insertion/Deletion polymorphism [ACE (I/D)] polymorphism in diabetic nephropathy progression in those patients. In present study, 106 T2DM patients and 102 healthy control individuals were enrolled. Serum glucose, copeptin, KIM-1, total cholesterol (TChol), triglycerides (TG), estimated glomerular filtration rate (eGFR) and UPb levels and ACE (I/D) polymorphisms were assessed in both groups. Results mentioned to significant variations in all parameters compared to in T2DM group compared to control group. Serum copeptin and UPb demonstrated significant difference in diabetic smokers (DS) and diabetic non-smokers (DNS) groups while KIM-1 exhibited significant change between DNS and healthy control non-smokers (CNS) groups. Positive relation was recorded between serum glucose and KIM-1 while negative one was found between serum copeptin and TChol. D allele was associated with significant variation in most parameters in T2DM, especially insertion/deletion (ID) polymorphism. ROC curve analysis (AUC) for serum copeptin was 0.8, p < 0.044 and for Kim-1 was 0.54, p = 0.13 while for uPb was 0.71, p < 0.033. Serum copeptin and UPb might be a prognostic biomarker for renal function decline in smoker T2DM patients while KIM-1 was potent marker in non-smoker T2DM with association with D allele of ACE I/D gene polymorphism.
The invention relates to a traditional Chinese medicine (TCM) for treating azoospermia and a preparation process thereof. The TCM is prepared from the following medicines: actinolite, antler, Tianxiong, fried semen allii tuberosi, desertliving cistanche, wine soaked medicine terminalia fruit, Chinese taxillus herb, flickingeria comata, Chinese eaglewood, silkworm moth stir-fried with wine and Chinese magnoliavine fruit, wherein the accuracy of the ratio of the medicines is +/-5%. The preparation process is characterized by comprising the following steps of: mixing the medicines and grinding the medicines into powder; and cooking glutinous rice into paste with wine, pouring the powder into the glutinous rice paste and stirring the materials uniformly when the glutinous rice paste is cooled to 10 DEG C and preparing pills with the materials. Patients take the TCM with warm saline water on an empty stomach twice a day, once in the morning and once in the evening and 12g once. Continuous 30 days is a course of treatment. The patients take the TCM for one-three courses of treatment and azoospermia can be cured. Alcohols are prohibited during medicine taking. Clinical use demonstrates that the TCM has especially obvious effect, reliable curative effect, no side effect and pretty good social and economic benefits and is convenient to take and simple to prepare.
Pregnancy Category D [see Warnings and Precautions (5.1)]

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue PRESTALIA as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.

In the unusual case that there is no appropriate alternative therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. Perform serial ultra-sound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, discontinue PRESTALIA, unless it is considered lifesaving for the mother. Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. Closely observe infants with histories of in utero exposure to PRESTALIA for hypotension, oliguria, and hyperkalemia [see Use in Specific Populations (8.4)].

Radioactivity was detectable in fetuses after administration of 14C-perindopril to pregnant rats.
The invention relates to a capsule for preventing cardio-cerebrovascular disease, which is a natural extract without toxic and side effects and can effectively reduce incidence rate of cardio-cerebrovascular disease. The invention is prepared from the following materials: large hellbender meat 10-20 parts by weight and red sage root 1-5 parts by weight. The process procedures are as follows: large hellbender without head and internal organs is peeled, cut into pieces, placed in the plate, and then dried and disintegrated. Solid product 1 can be obtained after 3-5 minutes microwave germ-killing and 80-120 mesh sieves. Red sage root is cleaned and extracted through water for 4-18 hours, and the weight ratio of red sage root and water is 1:4-20. The extracting liquid is immediately filtered and the filtering residue is collected with another container. Solid product 2 is obtained after the filtering liquid is concentrated and dried. Utilizing automatic purifying operation, the solid product 1 and the solid product 2 are combined, evenly mixed, and bottled into capsules. The package is finished after being plate-made with plastic-aluminum and tested.
Monitoring accurately a difference of a change of a position difference and an amount of load in operation and controlling appropriately a training apparatus. A training apparatus 100 comprises a fixed frame 1, a training rod 3, a motor, a rotation information outputting sensor, a tilt angle calculation unit 1131, a feedback current detecting unit 1133, a position difference calculation unit 1132, and a determination unit 1134. The training rod 3 is configured to tilt in at least one degree of freedom. The motor is configured to tilt the training rod. The rotation information outputting sensor is configured to output an amount of rotation of the motor. The tilt angle calculation unit 1131 is configured to calculate a tilt angle. The feedback current detecting unit 1133 is configured to detect a feedback current I. The position difference calculating unit 1132 is configured to calculate a position difference in a period of a predetermined first passing time T1. The determining unit 1134 is configured to notify an error when the position difference generated during the first passing time T1 is a first threshold [Phi]1 or more, or when a magnitude of the feedback current I keeps first magnitude of current I1 or more for a second passing time T2 or more.
Low-grade appendiceal mucinous neoplasm (LAMN) is principally characterized by low-grade cytology without evidence of invasion to other organs. We report a LAMN surgical case whose appendiceal tumor penetrated the sigmoid colon wall. An 87-year-old man was referred for endoscopic resection (ER) of a colon polyp. Despite four ERs over 5 years, the polyp recurred at the same site. Laparoscopic surgery revealed a dilated appendix firmly attached to the sigmoid colon. We performed en bloc resection of both the sigmoid colon and appendix without tumor exposure. The histopathological evaluation showed that the LAMN had penetrated the sigmoid colon wall, forming two polyps on the colonic mucosa. In cases where the appendiceal-colonic fistula is suspected, en bloc resection of the appendix and colon wall should be considered.
PURPOSE: To obtain a percutaneous, absorption-type plaster capable of giving sustention in drag release and higher application, difficult to peel off and easy to attach. CONSTITUTION: This percutaneous absorption-type plaster is made by laminating a base material 1, a first adhesive layer 2, a net layer 3, a second adhesive layer 4 and a peeling paper 5 in this order. The net layer 3 has an area narrower than that of other lamination bodies. A periphery part is formed by laminating the base material 1, the first adhesive layer 2, the second adhesive layer 4 and a peeling paper 5 on the outer periphery of the net layer 3. The net layer 3 is used for storing a medicine. When the medicine remains in the net layer 3, it takes time for the medicine to pass through the second adhesive layer 4 and the sustention of the medicine is enhanced. Inside vapor pressure becomes higher and utilization of the medicine becomes higher. The periphery part adheres closely and is difficult to be peeled off. It absorbs strain and stress as it is stretchable. The net layer is capable of supporting the plaster and easily attachable to the skin.
Participants in the University of Pittsburgh Claude D. Pepper Center community research registry. Potential participants will have stable regimens of 5+ prescribed medications and recent physician contact but no hospitalization in the prior 6 months.