anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study evaluates the response of dairy cows to short and extended heat stressing conditions (from 1 to 28 days), as expressed in changes in their behavior. Due to climate change, heat stress and strong heat waves are frequently affecting the productivity and behavior of dairy cows. In the five years under study from 2018 to 2022, two were characterized by extremely strong heat waves occurring in the region analyzed in this study (Northern Italy). The dairy cattle farm involved in this study is located in Northern Italy and includes about 1 600 Holstein Friesian lactating dairy cows. Phenotypic data were provided by the Afimilk system and compromised behavioral and productive traits. Behavioral traits analyzed were activity, rest time, rest bouts, rest ratio, rest per bout and restlessness. Production traits were daily milk yield, average milking time, somatic cell count, fat percentage, protein percentage and lactose percentage. Climate data came from the National Aeronautics and Space Administration/Prediction of Worldwide Energy Resources database. Heat stress was analyzed considering Temperature-Humidity Index (THI) averaged over 28 different time windows of continuous heat stress. Results showed that rest time and milk yield were the two traits most affected by the increased THI. Rest time was immediately affected by high THI, showing a marked decrease already from 1d window and maintaining this all over the other windows. Furthermore, results show that rest time and rest ratio were only slightly negatively correlated with milk yield (-0.14 and -0.15). In addition, heat stress has a different effect depending on parity and lactation stages on the studied traits. In conclusion, the results indicate that heat stress increases activity and compromises milk production, rest time and milk quality traits. Results further suggest that rest time can be a better parameter than activity to describe the effects of heat stress on dairy cattle. The novel approach used in this study is based on the use of different time windows (up to 28 days) before the emergence of undesired THI and allows to identify the traits that are immediately influenced by the undesirable THI values and those that are influenced only after a prolonged heat stress period.
Cytarabine (Ara-C) is a commonly used chemotherapeutic drug for the treatment of leukemia, known for its significant tolerability. The down regulation of miR-203 in leukemia cells suggests its potential involvement in the pathogenesis of leukemia. In this study, we investigated the effects and possible mechanisms of miR-203 and Ara-C on proliferation and apoptosis of human leukemia K562 cells which were cultured with Ara-C and/or with transfection of miR-203 expression vectors. Our results showed that the combination of Ara-C and miR-203 synergistically inhibited the proliferation of K562 cells and the sensitivity of leukemia cells to Ara-C was increased by 2.5-fold with trasfection of miR-203. The proportion of apoptotic cells in the Ara-C and miR-203 combination group was higher than Ara-C or control plasmid group. Caspase-3 and caspase-9 activities were increased in Ara-C and miR-203 combination group. miR-203 down regulated the protein level of Bcr/abl in K562 cells compared with plasmid control. In conclusion, Ara-C in combination with miR-203 has a synergistic effect of proliferation inhibition and apoptosis induction in chronic myelogenous leukemia K562 cells, which may be associated with miR-203 down regulating Bcr/abl, thereby inhibiting cell proliferation and promoting cell apoptosis.
High-intensity circuit exercise training will be performed 3 times weekly for 12 weeks in a group setting. Circuit training is an exercise modality consisting of a series of exercises at different stations. Exercise training will be delivered by VTEL broadcast from the Salem VAMC to participants at the Atlanta VAMC and Baltimore VAMC. Rooms will be equipped with steps, hand and ankle weights, dumbbells, chairs and bands. No stationary exercise equipment will be used in either AEX or RT.
The method for producing herbal substance possessing choleretic and hepatoprotective activities comprises extraction of the chopped herbal raw material, filtration and evaporation. To the dry herb of the marigold, ethanol is added until the "mirror" on the surface. The raw material is extracted at room temperature and filtered through a vacuum filter. The resulting filtrate is evaporated to a thick residue. The extraction cake is further extracted with hot water on the water bath, filtered and re-extracted twice. The aqueous filtrates are combined and evaporated to obtain a thick residue. The residues after ethanol and water extractions are combined and dried.
1. Technical Result Increase in efficiency of treatment of Alzheimer's disease. 2. Essence The present invention provides a method of treating Alzheimer's disease using a novel compound of formula (I), wherein X, Y and P have the values indicated in the description. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of formula (I) and a method of imaging amyloid deposits using isoindoline derivatives. 3. Field of Application Medicine.
The purpose of this protocol is to investigate plastic changes in human cerebral cortex in health and disease. The overall hypothesis is that it is possible to identify neuroimaging patterns reflecting reorganization in the human cerebral cortex using fMRI and that it is possible to obtain information on the mechanisms underlying some of these plastic changes by using magnetic resonance spectroscopy (MRS) of GABA. This information is potentially important for the understanding of mechanisms of cortical reorganization operating in humans. Patients and normal volunteers will be scanned at rest and during performance of different tasks. These studies should provide new information on mechanisms of human plasticity. The MRI techniques used for that purpose are functional MRI (fMRI), MR spectroscopy (MRS), and conventional MRI with magnets between 1.5 and 4 tesla.
Biopsy is the clinical standard for diagnosing lymph node (LN) metastasis, but it is invasive and poses significant risk to patient health. Magnetic resonance imaging (MRI) has been utilized as a noninvasive alternative but is limited by low sensitivity, with only ∼35% of LN metastases detected, as clinical contrast agents cannot discriminate between healthy and metastatic LNs due to nonspecific accumulation. Nanoparticles targeted to the C-C chemokine receptor 2 (CCR2), a biomarker highly expressed in metastatic LNs, have the potential to guide the delivery of contrast agents, improving the sensitivity of MRI. Additionally, cancer cells in metastatic LNs produce monocyte chemotactic protein 1 (MCP1), which binds to CCR2+ inflammatory monocytes and stimulates their migration. Thus, the molecular targeting of CCR2 may enable nanoparticle hitchhiking onto monocytes, providing an additional mechanism for metastatic LN targeting and early detection. Hence, we developed micelles incorporating gadolinium (Gd) and peptides derived from the CCR2-binding motif of MCP1 (MCP1-Gd) and evaluated the potential of MCP1-Gd to detect LN metastasis. When incubated with migrating monocytes in vitro, MCP1-Gd transport across lymphatic endothelium increased 2-fold relative to nontargeting controls. After administration into mouse models with initial LN metastasis and recurrent LN metastasis, MCP1-Gd detected metastatic LNs by increasing MRI signal by 30-50% relative to healthy LNs. Furthermore, LN targeting was dependent on monocyte hitchhiking, as monocyte depletion decreased accumulation by >70%. Herein, we present a nanoparticle contrast agent for MRI detection of LN metastasis mediated by CCR2-targeting and demonstrate the potential of monocyte hitchhiking for enhanced nanoparticle delivery.
Cosmetic emulsion of algae and obtaining procedure by freezing. The cosmetic emulsion of seaweed is prepared with a mixture of algae such as undaria pinnatifida, phorphyra purpurea, chondrus crispus, laminaria ochroleuca, himanthalia elongata by agitation or liquefaction with which a base mixture is obtained to which an oil emulsion will be added. Water or a water-in-oil emulsion. The result of the new mixture obtained will be frozen for its conservation of nutrients. It is used for the cosmetic application as an innovative solution to provide vitamins and nutrients without chemical stabilization thereof to the final consumer. (Machine-translation by Google Translate, not legally binding)
There is a need for customized formulations of dietary supplements and therapeutics based on the genetic, physical, physiological, and medical needs of an individual. Conventionally, typical formulations of supplements and therapeutics are prepared as a pill or liquid in batches comprised of a fixed set of ingredients to be used by the average person with little regard to the needs of that specific individual. Diagnostic advances in individual genomic sequencing and molecular diagnostics, for example, result in a need for corresponding innovation in the formulation and packaging of a range of compounds and biologics in a small batch production that is economic for individual consumption that addresses respective ailments. Further, there is recognized need to encourage greater consumer compliance in daily intake of key nutritional and pharmacological components in order to obtain desired outcomes, and a solution that uses natural human drives, such as taste and pleasure, if combined to suit individual subjective preferences will likely improve voluntary compliance with prescriptive nutrition and medicine. The embodiments disclosed herein provide a system and method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The system and method involves receiving health-related information for an individual from the individual, their agent, or a service provider, the health-related information including one of genetics or metabolomic profile data of the individual. Taste-related preference data is then received from the individual. Based on the health-related information, the present invention determines a formulation for an ingredient for the individual, and based on the taste-related preference data, determines a filler medium that is consistent with the taste-related preference data, wherein the filler medium is a thixotropic semi-solid hydrocolloid that allows dissolution or suspension of compounds in a form that is stable until agitated or extruded at which point the semi-solid hydrocolloid becomes fluid and can be dispensed. A preparation apparatus is involved that includes a formulation device configured to prepare the formulation, as well as a medium formulation device configured to prepare the filler medium. A dispenser is configured to dispense a predetermined amount of the formulation within the filler medium to form a dosage, wherein the thixotropic semi-solid hydrocolloid is solubilized to embed the formulation and then reformed as a semi-solid. The dosage is packaged as an individual use dosage in a packaging material.
Single parenteral administration of 60000 U of epoetin alfa. The objectives of the second phase are to investigate the effects of the highest safe dose on infarct size, left ventricular remodeling and endothelial progenitor cells.
Benzodipyran salts (Ie with organic or inorganic cations which have water-solubility of 3 wt/wt. % (pref. 0.5 wt/wt. %) at 20-50 degrees C are new (where at least one gp. R is an organic or inorganic cation giving the necessary solubility; the other may be H). The cpds. are antiallergics which inhibit the release or action of pharmacological mediators resulting from specific antigen/antibody reactions e.g. combination of a reagininic antibody with a specific antigen. They are used to treat allergic asthma (including intrinsic asthma), hay fever, urticaria etc. (I) are absorbed more slowly or have longer duration of activity and have less side-effects (e.g. broncho-constriction when administered by inhalation) than disodium cromoglycate or the disodium salt or free acid corresp. to (I). They are administered orally, rectally or by oral or nasal inhalation in daily doses of 0.1-1000mg, esp. 0.5-50 mg administered as several unit doses (e.g. 1-3 unit doses). In treatment of hay fever doses of 0.1-1mg are administered 1-8 time daily.
BACKGROUND: Synchronous abscesses of the prostate and seminal vesicles represent a rare but clinically significant form of purulent retention. They pose diagnostic and therapeutic challenges and are associated with considerable morbidity and a high risk of sepsis.
CASE PRESENTATION: We present the case of a 60-year-old Caucasian man with a history of insulin-dependent diabetes mellitus, who had a voluminous prostatic abscess associated with a right seminal vesicle abscess due to compression of the right ejaculatory duct, and who presented to our department with sepsis. He had clinical and radiological confirmation with computed tomography scan and magnetic resonance imaging. The patient underwent percutaneous drainage of the prostatic abscess resulting in the subsidence of the seminal vesicle abscess. The treatment also consisted on prolonged antibiotic therapy. The clinical evolution was favorable.
CONCLUSION: We conclude that prostatic abscesses can lead to synchronous seminal vesicle abscesses due to ejaculatory duct compression. Percutaneous drainage of the prostatic abscess by transrectal ultrasound-guided drainage, combined with prolonged antibiotic therapy, can effectively treat both abscesses.
The proposed study is a matched cohort design. Subjects will be matched with 24 historical control patients who received similar cold stored ECD grafts. Subjects will be matched on known covariates including donor age, donation after cardiac death, steatosis, both warm and cold ischemia times, recipient age, MELD score and disease etiology. Additional analyses will be performed on historical control blood and/or tissue samples previously collected and stored in the study's sample repository.
The invention provides an oligosaccharide oat beverage capable of treating hyperlipoidemia and hyperglycemia and improving gastrointestinal tract function and a manufacturing method thereof by hydrolysis of three enzymes and fine grinding. The manufacturing method comprises the following steps: carrying out fine grinding on the oat meal to obtain the powder of which the average particle size is less than about 100 mu m, dissolving the oat powder in water to form oat slurry, and adding alpha-amylase, beta-amylase and trans-glucosidase to carry out enzyme treatment, thereby obtaining the oat beverage with rich functional components. The oligosaccharide oat beverage integrally reserves oat beta-dextran, and also contains oligo-isomaltose component of which the content is higher than that in common oat products. The manufacturing method can integrally reserve the nutritional components of the whole oat grains and omit the filter operation, thereby being beneficial to increasing the utilization ratio of raw materials; and the method is completed under the conditions of fermentation and sterilization in the optimal short time, thereby avoiding the possibility of rancidity of oat slurry in the processing procedure. When the oligosaccharide oat beverage is used for human testing for assessing physiologic effect, the test proves that the oligosaccharide oat beverage can lower the total cholesterol, low-density lipoprotein cholesterol, triglyceride and fasting blood-glucose value in blood. The oligosaccharide oat beverage tastes savoury, thick and smooth like milk, and maintains the natural flavor of oat; and thus, the invention changes the traditional way for eating oat, greatly raises the nutrition health-care value of oat processed products, and has the potentials of preventing and treating hyperlipoidemia, hyperglycemia and other life-style related diseases and improving the gastrointestinal tract function.
A method and apparatus for a pellet fuel burning heating unit for burning corn or wood pellets having a balanced pressure system having a four-way split combustion intake airstream. The invention includes a combustion air blower system for providing combustion air into a firebox containing a burner under positive pressure and at the same time providing a negative pressure to remove the combustion gases from the firebox. A pressure regulator and air splitter maintains a balance between the positive and negative pressure and adjusts the air flow into the firebox and out the exhaust. The exhaust is provided through a bank of exhaust tubes running from the top of the firebox to an exhaust manifold. The blower air moves into the pressure regulator and air splitter dividing the air flow such that a portion enters the heating unit exhaust manifold to produce a negative pressure and the remaining portion enters the heating unit burner under positive pressure. Such remaining positive pressure portion is split three ways, with a flow stream directed at the fuel bed in the burner, a flow stream directed concentrically with a fuel pellet feed toward the region directly above the burner and a flow stream directed along the firebox door window. This flow split results in improved combustion efficiency of the fuel pellets and is self-regulating as between the relative amounts of air between the burner fuel bed and the region above the burner. The flow directed above the burner is concentric with the fuel feed line and hence reduces the likelihood of flame or smoke entering the fuel feed lines. The combination of air flow through the burner and directly above the burner results in a turbulence which ensures each corn kernel or pellet of fuel is sufficiently surrounded by combustion air to efficiently burn each kernel or pellet. The flow along the firebox door window prevents buildup of soot or discoloration of the glass in the door. A second, room air blower system is provided which directs ambient air around the exhaust tube bank and through vents in the heating unit housing into the room or space to be heated.
Glycine N-acyltransferase (GLYAT), known to influence glycine metabolism, has been implicated in the progression of various malignant tumours. However, its clinical relevance in hepatocellular carcinoma (HCC) remains unexplored. Here, GLYAT expression levels in HCC tissues were significantly reduced compared to normal liver tissues. Similarly, GLYAT expression levels in Huh 7, HepG2, PLC and SK-HEP1 were lower than those in LO2. Receiver operating characteristic curve analysis demonstrated that GLYAT exhibited good diagnostic performance for HCC. Kaplan-Meier analyses suggested that decreased GLYAT expression was correlated with poorer progress in HCC. Low GLYAT expression was significantly associated with gender and histologic grade. Multivariate Cox regression analysis identified low GLYAT expression and T stage as independent prognostic factors. Nomograms based on GLYAT mRNA expression and T stage showed good concordance with actual survival rates at 1, 2, 3 and 5 years. Moreover, GLYAT downregulation in the Huh 7 cell line enhanced cell proliferation, invasion and migration abilities, while GLYAT overexpression in the HepG2 cell line inhibited these abilities. HCC patients with low GLYAT expression exhibited a predisposition to immune escape and poor response to immunotherapy. This research revealed that GLYAT holds promise as both a prognostic biomarker and a potential therapeutic target in HCC.
BACKGROUND: Understanding sexual lifestyles and how they change over time is important for determining the likelihood of sexual health outcomes. Standard descriptive and regression methods are limited in their ability to capture multidimensional concepts such as sexual lifestyles. Latent Class Analysis (LCA) is a mixture modelling method that generates a categorical latent variable to derive homogenous groups from a heterogeneous population. Our study investigates (1) the potential of LCA to assess change over time in sexual lifestyles and (2) how quantifying this change using LCA compares to previous findings using standard approaches.
METHODS: Probability-sampled data from three rounds of the National Survey of Sexual Attitudes and Lifestyle (Natsal) were used, restricted to sexually active participants (i.e., those reporting sexual partners in the past year) aged 16-44 years (N1990 = 11,738; N2000 = 9,690; N2010 = 8,397). An LCA model was built from four variables: number of sexual partners (past year), number of partners without a condom (past year), age at first sex and self-perceived HIV risk. Covariates included age, ethnicity, educational attainment, same-sex attraction, and marital status. Multinomial regression analyses and Chi-Squared tests were used to investigate change over time in the size of each class.
RESULTS: We successfully used a LCA approach to examine change in sexual lifestyle over time. We observed a statistically significant increase between 1990 and 2010 in the proportion of men (χ2 = 739.49, p < 0.01) and women (χ2 = 1270.43, p < 0.01) in a latent class associated with reporting 2 or more partners in the last year, relatively high probabilities of reporting condomless sex partners, greater self-perceived HIV risk, and a high probability of first sex before age 16 years, increasing from 19.5% to 31.1% (men) and 9.9% to 22.1% (women).
CONCLUSION: Our results indicate the viability of LCA models to assess change over time for complex behavioural phenomena. They align with previous findings, namely changing sexual lifestyles in Britain in recent decades, partnership number driving class assignment, and significant sex differences in sexual lifestyles. This approach can be used to extend previous LCA models (e.g., to investigate the impact of COVID-19 on sexual lifestyles) and to support empirical evidence of change over time, facilitating more nuanced public health policy.
The aim of this study was to assess the efficacy of Gow-Gates and inferior alveolar nerve block on success rate of anesthesia in patients with irreversible pulpitis. In this prospective, randomized, double-blind study , forty healthy patients with symptomatic irreversible pulpitis and including criteria who failed to infra alveolar nerve block injection (without lip numbness) have been randomly divided into two groups on a random basis and have received Gow-Gates or another inferior alveolar nerve block injection. Their pain has been evaluated by electric pulp tester every 5 minutes for two times. Endodontic access cavity preparation has been initiated after complete anesthesia. If patients felt any pain during the steps of caries or dentin removal, Endodontic access cavity preparation or canal working length determination, treatment has been stopped and their pain has been measured by Heft Parker 170 mm Visual Analog Scale (Zero as no pain and 170 as maximum pain ). The patients have been instructed to rate any pain during each of the mentioned steps. The data have been analyzed by Mann-U-Whitney and CHI- SQUARE tests.
A therapeutic composition especially an injection comprises a solution of erythromycin in a lower dialkyl carbonate in which the alkyl groups have from 1 to 3 carbon atoms.  Specified dialkyl carbonates are dimethyl carbonate, diethyl carbonate, dipropyl carbonate and ethyl isopropyl carbonate.  The erythromycin is the free antibiotic or a therapeutically acceptable form thereof such as erythromycin ethyl carbonate, erythromycin propionate or other esters soluble in the dialkyl carbonate.  The antibiotic is employed in quantities of 25 to 100 and preferably 50 mg per mil of solution. Optional additions are (a) local anaesthetics e.g. procaine, benzocaine and 1- benzamido -1- phenyl -3-piperidinopropane (see Specification 739,741) (b) preservatives, e.g. phenol, benzyl alcohol and chlorobutanol (c) other antibiotic and/or chemotherapeutic agents, and (d) pharmaceutical adjurants.