anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Ocular Surface (OS) somatosensory innervation detects external stimuli producing perceptions, such as pain or dryness, the most relevant symptoms in many OS pathologies. Nevertheless, little is known about the central nervous system circuits involved in these perceptions, and how they integrate multimodal inputs in general. Here, we aim to describe the thalamic and cortical activity in response to OS stimulation of different modalities. Electrophysiological extracellular recordings in anaesthetized rats were used to record neural activity, while saline drops at different temperatures were applied to stimulate the OS. Neurons were recorded in the ophthalmic branch of the trigeminal ganglion (TG, 49 units), the thalamic VPM-POm nuclei representing the face (Th, 69 units) and the primary somatosensory cortex (S1, 101 units). The precise locations for Th and S1 neurons receiving OS information are reported here for the first time. Interestingly, all recorded nuclei encode modality both at the single neuron and population levels, with noxious stimulation producing a qualitatively different activity profile from other modalities. Moreover, neurons responding to new combinations of stimulus modalities not present in the peripheral TG subsequently appear in Th and S1, being organized in space through the formation of clusters. Besides, neurons that present higher multimodality display higher spontaneous activity. These results constitute the first anatomical and functional characterization of the thalamocortical representation of the OS. Furthermore, they provide insight into how information from different modalities gets integrated from the peripheral nervous system into the complex cortical networks of the brain. KEY POINTS: Anatomical location of thalamic and cortical ocular surface representation. Thalamic and cortical neuronal responses to multimodal stimulation of the ocular surface. Increasing functional complexity along trigeminal neuroaxis. Proposal of a new perspective on how peripheral activity shapes central nervous system function.
Postmenopausal women and premenopausal women receiving Luteinizing Hormone-Releasing Hormone (LHRH) analogues, aged ≥ 18 years with ER positive and HER2 negative locally advanced or metastatic breast cancer that had not received any therapy for the metastatic disease. Patients are not eligible if they are candidates for a local treatment with a radical intention. Subjects must have histologic confirmation of the estrogen and/or progesterone-positive and HER2 negative receptors breast cancer. Evidence of measurable or evaluable metastatic disease is required.
Previous studies have shown sleep deprivation is increasingly reported as one of the causes of female infertility. However, how and by what relevant mechanisms it affects female fertility remains unclear. In this study, female mice underwent 72 hours of total sleep deprivation (TSD) caused by rotating wheel or 2 different controls: a stationary wheel, or forced movement at night. Even though, there was no significant difference in the number of eggs ovulated by the TSD mice compared to the control groups. Overall levels of estrogen and FSH were lower throughout the estrus cycle. A total of 42 genes showed significant differential expression in GV oocytes after TSD by RNA sequencing (RNA-Seq). These included genes were enriched in gene ontology terms of mitochondrial protein complex, oxidoreductase activity, cell division, cell cycle G1/S phase transition, as well as others. The increased concentrations of reactive oxygen species (ROS) in germinal vesicle (GV) and metaphase II (MII) oocytes from TSD mice were observed, which might be induced by impaired mitochondrial function caused by TSD. The GV oocytes displayed increased mitochondrial DNA (mtDNA) copy number and a significant transient increase in inner mitochondrial membrane potential (Δψm) from the TSD mice probably due to compensatory effect. In contrast, MII oocytes in the TSD group showed a decrease in the mtDNA copy number and a lower Δψm compared with the controls. Furthermore, abnormal distribution of mitochondria in the GV and MII oocytes was also observed in TSD mice, suggesting mitochondrial dysfunction. In addition, abnormal spindle and abnormal arrangement of chromosomes in MII oocytes were markedly increased in the TSD mice compared with the control mice. In conclusion, our results suggest that TSD significantly alters the oocyte transcriptome, contributing to oxidative stress and disrupted mitochondrial function, which then resulted in oocyte defects and impaired early embryo development in female mice.
BACKGROUND: There has been no consensus on what power of radiofrequency energy can be used to produce the best surgical results in patients with atrial fibrillation. In addition, patients undergoing local anesthesia and fentanyl analgesia may experience pain when radiofrequency ablation is performed. This study investigated the effect of different power radiofrequency ablations in treatment and postoperative pain in patients with atrial fibrillation.
METHODS: A retrospective study was performed with 60 patients who underwent radiofrequency ablation for atrial fibrillation between January and June 2023. Patients were divided into 2 groups according to the power of the radiofrequency ablation catheter used, with 30 patients in the conventional power group (35 W) and 30 patients in the high-power group (50 W). The cardiac electrophysiological indexes and postoperative pain of the 2 groups were compared.
RESULTS: Most of the procedural key parameters between the 2 groups had no significant differences. However, the total application time during radiofrequency ablation and pulmonary vein isolation time in the high-power group were significantly shorter than those in the conventional power group (p < 0.001). Patients in the high-power group reported significantly less pain than those in the conventional power group in the immediate postoperative period and the late postoperative period (p < 0.001).
CONCLUSIONS: High-power radiofrequency ablation showed a shorter treatment time, and could reduce postoperative pain compared to conventional power ablation.
An osmotic system is disclosed for delivering an agent. The system comprises a semipermeable wall surrounding a compartment. The compartment contains a layer of a compound that is insoluble in an exterior fluid, and juxtaposed with a layer of an agent that is soluble in the fluid. A passageway through the wall connects the exterior of the system with the interface between the wall and the insoluble compound. In operation, agent is delivered from the system, by the agent imbibing fluid into the compartment to form a saturated solution of agent, that is moved along the interface between the wall and the insoluble compound towards the passageway. The saturated solution is moved continuously by the corresponding imbibition of fluid, and as the solution moves along the interface it imbibs fluid, is diluted and delivered below a saturated concentration to the exterior of the system. The invention also concerns a two layered structure comprising a layer of an aqueous insoluble compound and a layer of an aqueous soluble compound.
In a non-face-to-face health management system using a wearable device and a non-face-to-face health management method using same, the health management system comprises: a wearable device; a communication network; a data server; a monitoring unit; and a data generation unit. The wearable device is mounted or attached to a wearer and collects biosignals and location information of the wearer. The communication network transmits, by wire or wirelessly, the information collected by the wearable device. The data server stores the collected information transmitted by the communication network. The monitoring unit calls the information stored in the data server and displays the information externally. The data generation unit generates statistical data by integrating health status and location information of the wearer on the basis of the stored information or the displayed information.
Patients undergoing coronary artery surgery routinely receive aspirin therapy, as a standard treatment for preserving bypass graft patency. Although the dual antiplatelet therapy post CABG has not been recommended by guideline, present studies indicated the patients could benefit from the dual anti-platelet therapy. Using clopidogrel+aspirin could significantly reduce the early saphenous vein graft occlusion. . Many surgeons empirically prescribe dual anti-platelet therapy in spite of the indeterminacy of the clinical effects. ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y12-receptor antagonist. The ONSET/OFFSET Study also shows that ticagrelor achieved much rapid and greater platelet inhibition than high-loading-dose clopidogrel in patients with stable CAD. ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y12-receptor antagonist. The ONSET/OFFSET Study also shows that ticagrelor achieved much rapid and greater platelet inhibition than high-loading-dose clopidogrel in patients with stable CAD.
Recent investigation of a constitutively active ADAMTS13 variant (caADAMTS13) in murine models of acute ischaemic stroke (AIS) have revealed a potential anti-inflammatory mechanism of action contributing to its protective effect. However, it remains unclear whether these observations are a direct result of VWF proteolysis by caADAMTS13. We have implemented state of the art in vitro assays of neutrophil rolling and transmigration to quantify the impact of caADAMTS13 on these processes. Moreover, we have tested caADAMTS13 in two in vivo assays of neutrophil migration to confirm the impact of the treatment on the neutrophil response to sterile inflammation. Neutrophil rolling, over an interleukin-1β stimulated hCMEC/D3 monolayer, is directly inhibited by caADAMTS13, reducing the proportion of neutrophils rolling to 9.5 ± 3.8 % compared to 18.0 ± 4.5 % in untreated controls. Similarly, neutrophil transmigration recorded in real-time, was significantly suppressed in the presence of caADAMTS13 which reduced the number of migration events to a level like that in unstimulated controls (18.0 ± 4.5 and 15.8 ± 7.5 cells/mm2/h, respectively). Brain tissue from mice undergoing experimental focal cerebral ischaemia has indicated the inhibition of this process by caADAMTS13. This is supported by caADAMTS13's ability to reduce neutrophil migration into the peritoneal cavity in an ischaemia-independent model of sterile inflammation, with the VWF-dependent mechanism by which this occurs being confirmed using a second experimental stroke model. These findings will be an important consideration in the further development of caADAMTS13 as a potential therapy for AIS and other thromboinflammatory pathologies, including cardiovascular disease.
FIELD: biotechnology, sorbents. SUBSTANCE: method involves alkaline treatment of hydrolytic lignin, the following washing out from alkali and dissolved compounds by three-fold extraction and suspension dilution with drinking water, neutralization of residual alkali with acid, lignin washing out from acid and salts by two-fold extraction and suspension dilution with drinking water followed by milling and dehydration of lignin. Lignin washing out is carried out by extraction using suspension dilution with drinking water up to the content of dry matter 40-100 g/l followed by intensive stirring of suspension for 15 min, not less, separation of cleared liquid at amount from 1/3 to 1/2 of obtained volume by decanting after its settling for 30 min, not less. Alkaline treatment and washing out of lignin is carried out in collector-mixer having ratio of height to diameter 3:1, not less. Lignin can be used as enterosorbent at different metabolic disorders and organism intoxications. EFFECT: simplified technology. 8 cl, 4 ex, 7 tbl
A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to activation by an antigen to which the immune system of the host; (human or animal) is to be made tolerant. The cells contain a genetic sequence of which the expression product (e.g. HSV1--TK--) may, when its production is increased so that it is present in a sufficient quantity within said trapped cells, react in situ with a pharmaceutically active substance (e.g. acyclovir) to induce the destruction of the cells and of means (e.g. a promoter of an interleukin receptor controlling the expression of said genetic sequence) which are specifically induced by an activation signal provided by the antigen to the cells, to cause the aforesaid increased production. The production of drugs implementing the above mentioned principles in order to prevent host immune system dysfunctions which are natural (autoimmune diseases) or induced (grafts), is also described.
The present invention discloses a granular formulation with heat-clearing and detoxicating, promotion of diuresis and tonglin function and preparation method and detection method. The granular formulation is made by Polygonum capitatum. (four seasons red) 2700 units, plantain 1300 units, dextrin 810 units and 30 Sodium cyclamate units in weight unit. Compared with current technology, the Sodium cyclamate is used as flavoring agent replacing steviosion in the invention, which overcomes problem of poor taste when taking steviosion as flavoring agent and difficulty in taking medicine to patients; dextrin dosage is increased so as to overcome problem of low yield of dry paste in actual production and insufficiency of extract quantity; thick paste density adjusted after liquid medicine concentrated, and can complete concentration process directly in decompression concentrator. No need of adding a great amount of water in pellet fabrication process which avoids waste of energy sources, equipment and human energy, reduces production cost, meanwhile guaranties product quality; and gallic acid shallow layer identification item is reestablished in quality detecing. The method is of good specificity, strong particularity and high sensitivity, has no interference to negative control, and can ensure product quality and curative effect.
The second treatment group received abobotulinumtoxinA (Dysport) on the right side of their face and onabotulinumtoxinA (Botox) on the left side of their face. Baseline treatment at Week 0 included the intradermal injection of onabotulinumtoxinA on one side of the face and abobotulinumtoxinA on the other. Patients were treated at Week 2 with traditional intramuscular injections consisting of onabotulinumtoxinA on the same side of their face as at Week 0 and abobotulinumtoxinA on the other side. Patients were treated based on individual need, and thus the treatment volumes were not controlled or standardized.
The invention discloses a paclitaxel polymer nanoparticle. The paclitaxel polymer nanoparticle can be used as a slow-release carrier of a paclitaxel medicament and is characterized in that the particle size of the nanoparticle is 50-800nm, a composition of the paclitaxel polymer nanoparticle contains the components of a biodegradable polymer material, the paclitaxel medicament and a stabilizing agent; the encapsulation rate of the paclitaxel medicament is within 2.0-6.0%; and the paclitaxel polymer nanoparticle has a paclitaxel slow-release effect. The invention also discloses a preparation method of the nanoparticle. The paclitaxel can be scattered in the nanoparticle prepared from the biodegradable polymer material under the condition of maintaining the original biological activity of the paclitaxel. Pure physical effects are played in the whole process, side effects brought by residue of other reagents in the chemical synthesis process can be effectively avoided, and the prepared nanoparticle can effectively play a role in medicament slow release. Compared with a conventional method, the preparation method does not need chemical reaction, and is simple in preparation process, relatively low in cost and relatively energy-saving.
BACKGROUND/AIMS: We examined the involvement of cholecystokinin (CCK) in the exacerbation of indomethacin (IND)-induced gastric antral ulcers by gastroparesis caused by atropine or dopamine in mice.
METHODS: Male mice were fed for 2 h (re-feeding) following a 22-h fast. Indomethacin (IND; 10 mg/kg, s.c.) was administered after re-feeding; gastric lesions were examined 24 h after IND treatment. In another experiment, mice were fed for 2 h after a 22-h fast, after which the stomachs were removed 1.5 h after the end of the feeding period. Antral lesions, the amount of gastric contents, and the gastric luminal bile acids concentration were measured with or without the administration of the pro- and antimotility drugs CCK-octapeptide (CCK-8), atropine, dopamine, SR57227 (5-HT3 receptor agonist), apomorphine, lorglumide (CCK1 receptor antagonist), ondansetron, and haloperidol alone and in combination.
RESULTS: IND produced severe lesions only in the gastric antrum in re-fed mice. CCK-8, atropine, dopamine, SR57227 and apomorphine administered just after re-feeding increased bile reflux and worsened IND-induced antral lesions. These effects were significantly prevented by pretreatment with lorglumide. Although atropine and dopamine also increased the amount of gastric content, lorglumide had no effect on the delayed gastric emptying provoked by atropine and dopamine. Both ondansetron and haloperidol significantly inhibited the increase of bile reflux and the exacerbation of antral lesions induced by atropine and dopamine, respectively, but did not affect the effects of CCK-8.
CONCLUSIONS: These results suggest that CCK-CCK1 receptor signal increases bile reflux during gastroparesis induced by atropine and dopamine, exacerbating IND-induced antral ulcers.
Chlamydia trachomatis (CT) is the most common sexually transmitted infections globally, and CT infection can enhance HPV persistence. Epidemiological analysis has shown that patients with CT/HPV coinfection have a higher risk of developing cervical cancer and exhibit more rapid progression to cervical cancer than patients with HPV infection alone. However, the mechanism has not been fully elucidated. Here, we report that CT infection supports HPV persistence by further suppressing the functions of Langerhans cells (LCs); in particular, CT further activates the PI3K pathway and inhibits the MAPK pathways in LCs, and these pathways are frequently involved in the regulation of immune responses. CT/HPV coinfection also impairs LC functions by reducing the antigen-presenting ability and density of LCs. Moreover, CT/HPV coinfection can alter T-cell subsets, resulting in fewer CD4 + and CD8 + T cells and more infiltrating Tregs. Moreover, CT/HPV coinfection decreases the CD4 + /CD8 + T cell ratio to below 1, coinfection also induces greater T lymphocytes' apoptosis than HPV infection, thus impairing cell-mediated immunity and accelerating the progress to cervical cancer.
The "Dental Team" at the Department for Oral and Maxillofacial Surgery in Trondheim takes care of patients before, during and also after radiotherapy in the head and neck area. In spite of the use of advanced radiation protocols and prevention measures such as fluoridation splints the team observes significant side effects, both under radiation and also on the long term after concluding treatment. Common problems are for example dermal and mucosal damages, reduced salivation, dysphagia and lesions of the teeth. Aim of the study is the investigation and documentation of side effects and complications in relation to the oral cavity. During the acute and postradiation phase a continuous follow-up over a longer lasting period is proceeded with registration of all relevant parameters. This includes among others dental status and evaluation of quality of life.
HE is delivered over a 9 week period with 1 1-hr individual session during week 1, 8 weekly 1.5-hr group counseling sessions during weeks 2-9, and 1 20-minute individual telephone session during week 4. Session content includes smoking health education program plus standard behavioral smoking cessation treatment. Participants also receive 8 weeks of nicotine patch.
Sedation brain refreshing liquid of this invention is a kind of preparation of the Chinese traditional medicine with unique effectiveness of Sedation brain awakening, promoting blood circulation and reducing swelling, regulating qi to alleviate pain, anti-stasis and eliminating macules, improving the circulation of heart and brain, decrease intracranial pressure, relieving spasm and pain,  and has the performance of promoting blood circulation without hurting yin, arresting bleeding without leaving stasis, goreing without heating, and it can be well absorbed by intestine and stomach with short period of treatment, fast effect. Dosage is at least for three days, but the longest period can be 25 days with average dosage of 7 days. Its curative ratio is as high as 98%. It can be used for treating external injured non-specific inflammation, thrilling injury, pain because of the swelling dui to gore and suggillation. It has obvious curative effect in treating diseases course by the gore of due to external injury such as skull and brain damage, light and medium cerebral concussion, sequela cerebral concussion, cerebral haemorrhage, skull fracture, soft tissue injury, coronary heart disease, angina, it has in the field of the Chinese traditional medical department of fractures and wounds solved the problem of which the standardized Chinese pure herbal medicine to treat difficult cases of disease. At the same time, it points out that for external damage of skull and brain, the principle is not be ignored but highly regarded,and be treated as early and fast as it can, so as to avoid sequela. If it had led sequela happened, it may course rheumatic disease, even make the patient cripple for life.
A significant contributor to the morbidity and mortality from COVID-19 is from the abnormal carbon dioxide and oxygen levels in COVID-19 patients. Metabolic studies done on COVID-19 patients have shown that these patients have abnormally high metabolic rates. High metabolic rates results in increased carbon dioxide production and increased oxygen usage, both of which can result in high carbon dioxide and low oxygen levels. As some patients with severe COVID-19 continue to have high carbon dioxide levels and/or low oxygen levels despite being on the ventilator, it is hypothesized that decreasing the metabolic rate in these COVID-19 patients will help their oxygen and carbon dioxide levels. Mild hypothermia is currently used in comatose survivors of cardiac arrest to improve mortality and neurological outcomes. Mild hypothermia is also an effective way to reduce metabolic demand. The aim is to apply mild hypothermia to COVID-19 patients to decrease metabolic rate in order to improve their oxygen and carbon dioxide levels. Although the application for mild hypothermia has been widely adopted in some patient populations, it has never been applied in COVID-19 patients. If we can develop a strategy to help improve the oxygen and carbon dioxide levels in COVID-19 patients, it may lead to improvements in their overall outcomes.