anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the field of bio-genetic engineering and provides a shuttle plasmid and a method for efficiently expressing cecropin and lysozyme genes. The invention constructs an escherichia coli-bacillus subtilis shuttle plasmid suitable for being expressed in prokaryotes (escherichia coli, bacillus subtilis and bacillus sphaericus). Cecropins expressed in the prokaryotes does not have a toxic action on hosts. The shuttle plasmid can successfully express the fusion protein of various cecropins such as human lysozyme, bovine lactoferrin, and the like. 6His is introduced into the expression plasmid constructed by the invention, which is convenient to purify, and the purified fusion protein identifies and correctly cut enzyme cutting sites among all fusion peptide segments through lysostaphin so as to release all functional peptides and enable the functional peptides to recover the activity; and moreover, enzyme separation and cutting are also saved, thus the method can be effectively, simply and conveniently used. The shuttle plasmid also has a certain common availability, and all suitable genes can be cloned and expressed.
OBJECTIVE: To comprehensively evaluate the effect of low birth weight on premature ovarian insufficiency.
METHODS: We performed a systematic review of the literature by searching MEDLINE, EMBASE, Web of Science, Scopus, Wanfang and CNKI up to August 2023. All cohort and case-control studies that included birth weight as an exposure and premature ovarian insufficiency as an outcome were included in the analysis. Data were combined using inverse-variance weighted meta-analysis with fixed and random effects models and between-study heterogeneity evaluated. We evaluated risk of bias using the Newcastle Ottawa Scale and using Egger's method to test publication bias. All statistical analyses were performed with the use of R software.
RESULTS: Five articles were included in the review. A total of 2,248,594 women were included, including 21,813 (1%) cases of premature ovarian insufficiency, 150,743 cases of low birth weight, and 220,703 cases of macrosomia. We found strong evidence that changed the results of the previous review that low birth weight is associated with an increased risk of premature ovarian insufficiency (OR = 1.15, 95%CI 1.09-1.22) in adulthood compared with normal birth weight. No effect of macrosomia on premature ovarian insufficiency was found.
CONCLUSIONS: Our meta-analysis showed strong evidence of an association between low birth weight and premature ovarian insufficiency. We should reduce the occurrence of low birth weight by various methods to avoid the occurrence of premature ovarian insufficiency.
Postoperative pain is among the main reasons for the decrease in respiratory function after upper abdominal surgery. Numerous studies have investigated the relationship between pain and respiratory function in abdominal surgeries. While the classic TAP block is used to relieve lower abdominal pain \[Th10-Th12\] after surgery, it may be insufficient in relieving pain in the upper abdominal wall \[Th6-Th9\]. The 4-point TAPb technique is employed to address the pain in this region. Ultrasound allows for non-invasive assessment of changes in diaphragm thickness along with changes in lung volume, and evaluating diaphragm mass and contraction is highly useful in diagnosing respiratory diseases. Previous studies have explored changes in diaphragm thickness and the relationship between total lung capacity \[TLC\], functional residual capacity \[FRC\], residual volume \[RV\] and diaphragm function. However, changes in diaphragm function due to pain prevention in patients undergoing '4-point' TAPb are not well understood. It is aimed to investigate the impact of the 4-point TAP block on the diaphragm in patients undergoing laparoscopic cholecystectomy under general anesthesia. The primary objective of this study is to use ultrasound to examine the effect of the four-point TAP block, administered for analgesia after laparoscopic cholecystectomy, on diaphragm thickness. The secondary objective is to assess the impact of the four-point TAP block on pain and the quality of patient recovery.
BACKGROUND: Stroke is a devastating global health issue, with high mortality and disability rates. The increasing prevalence of male infertility among reproductive-aged men has become a growing concern worldwide. However, the relationship between male infertility and stroke incidence remains uncertain. This study aimed to address this knowledge gap by employing a Mendelian randomization (MR) approach.
METHOD: Utilizing genetic instrumental variables derived from a genome-wide association study (GWAS) on male infertility and stroke, a two-sample MR design was implemented. Five different analysis methods, with inverse-variance weighted as the primary approach, were used to examine the genetic causal associations between male infertility and various stroke subtypes. Heterogeneity analysis, pleiotropy tests, and leave-one-out validation were conducted to assess heterogeneity, evaluate pleiotropy, and ensure the robustness of the findings.
RESULT: The results indicate a potential lower risk of small vessel stroke associated with male infertility (odds ratio, 95% confidence interval: 0.82, 0.68 to 0.99, p=0.044), although no significant impact on other stroke subtypes was observed. The study exhibited low heterogeneity and no apparent pleiotropy; however, the stability of the results was not optimal.
CONCLUSION: Male infertility might potentially confer a protective effect against small vessel stroke risk. Caution is warranted due to potential confounding factors. Additional studies are necessary to confirm these findings and provide further validation.
<P>PROBLEM TO BE SOLVED: To provide an agent for effectively alleviating symptoms of fatigue caused by alcohol intake of a healthy person, i.e. alcoholic fatigue.  <P>SOLUTION: Alcohol drinking is a widely accepted custom for living a fulfilling life such as stress release and communication improvement, however, alcohol drinking frequently causes fatigue such as next-day weariness. For solving the problem, there is provided the alcoholic fatigue alleviating agent to safely and effectively alleviate and improve fatigue caused by alcohol intake, i.e. alcoholic fatigue by using ornithine or its salt, or using ornithine or its salt in combination with one or more components selected from the group consisting of turmeric, fermented turmeric extract and curcumin. The alcoholic fatigue alleviating agent can be administered before or after drinking the alcohol or administered by continuous administration.  <P>COPYRIGHT: (C)2011,JPO&INPIT
The invention discloses a medicine for preventing and treating habitual abortion and premature delivery, comprising 17 kinds of herbs, such as red ginseng, bighead atractylodes rhizome, and donkey-hide gelatin, and the medicine can be prepared into honey bolus, tablets, capsules, condensed pills, oral liquid and other dosage forms. The invention belongs to the field of traditional Chinese medicine. Reasons of habitual abortion and premature delivery comprise body deficiency of Qi and blood, fetal malnutrition, cold invasion of uterus, deficiency of spleen and kidney, incontinence in lust, complete curettage of uterine cavity, uterine curetlage, induction of labor, artificial abortion, and damage of uterus. Various preparations of the medicine have the effects of warming the middle, invigorating spleen, invigorating qi, harmonizing the stomach, promoting qi-blood generation, lifting foetus and internal organs by tonifying middle qi, tonifying kidney yin and yang, promoting foetus stability, supplementing liver, kidney, Chong Channel, Ren Channel, essence and blood, supplying nutrition to foetus, and the like. The whole formula has thorough composition, strict compatibility and precise and appropriate selection of the herbs so as to realize strong synergism. The medicine is a rare secret prescription for preventing and treating habitual abortion and premature delivery. Clinic application in over forty years proves that the therapeutic effect is definite without toxic or side effect. By retrieval of existing data, patent publications similar to the invention which is not yet discovered.
The ApexM Device (InControl Medical) is a cylindrical inflatable instrument with electrodes on the dorsal and ventral sides. It is a battery operated, non-implanted device which will be inserted into the vagina and will stimulate the pelvic floor muscles. This device has been shown to be safe and effective for clinical use. Stimulation will alternate between 13 and 50Hz. The initial intensity will be set by the clinician at the patient's initial visit and will be increased in a standard fashion over the duration of the trial.
BACKGROUND: Laryngeal cancer (LC) is among of the most frequent head and neck cancers, associated to a high social impact and mortality. Unfortunately, the current treatment outcomes of LC are often scant, with different factors affecting patient's prognosis (i.e., advanced age, advanced disease stage, lymph node involvement, tumor pathological features, type of intervention). The aims of the present study were: 1) to evaluate the epidemiological and clinical features of patients affected by LC; and 2) to focus on tumor risk factors affecting patient's overall survival (OS) and recurrences.
METHODS: A retrospective analysis of all patients affected by LC and surgically treated at two different hospital settings has been performed.
RESULTS: Two hundred twenty-five patients were enrolled in the present study; of these 189 were males (84%) and 36 (16%) were females. The most frequently performed surgery was total laryngectomy. Thirty-two (14.2%) patients experienced local recurrence, while 15 patients (6.6%) had regional recurrence and 15 distant metastases. Multivariate analysis showed that locoregional recurrence was associated to the occurrence of distant metastases (P=0.002, HR=25,35). Analyzing OS, the only statistically significant factor that correlated with an increased risk of mortality (P<0.015, HR=2,45) was locoregional recurrence.
CONCLUSIONS: The present study confirms the literature data about age and sex distribution of LC, about tumors localization, lymph nodes metastasis and distant metastasis incidence and OS rate, based on T and N stage. Interestingly, within this series, the presence of locoregional recurrence or distant metastasis is related to a worst prognosis and a lower overall survival rate.
Trigeminal neuralgia (TN) is an intense and debilitating orofacial pain. The gold standard treatment for TN is carbamazepine. This antiepileptic drug provides pain relief with limited efficacy and side effects. To study the antinociceptive potential of cannabidiol (CBD) and its fluorinated analog PECS-101 (former HUF-101), we induced unilateral chronic constriction injury of the infraorbital nerve (IoN-CCI) in male Wistar rats. Seven days of treatment with CBD (30 mg/kg), PECS-101 (3, 10, and 30 mg/kg), or carbamazepine (10 and 30 mg/kg) reduced allodynia and hyperalgesia responses. Unlike carbamazepine, CBD and PECS-101 did not impair motor activity. The relief of the hypersensitive reactions has been associated with transient receptor potential vanilloid type 1 (TRPV1) modulation in the trigeminal spinal nucleus. CBD (30 mg/kg) and PECS-101 (10 and 30 mg/kg) reversed the increased expression of TRPV1 induced by IoN-CCI in this nucleus. Using a pharmacological strategy, the combination of the selective TRPV1 antagonist (capsazepine-CPZ - 5 mg/kg) with sub-effective doses of CBD (3 and 10 mg/kg) is also able to reverse the IoN-CCI-induced allodynia and hyperalgesia responses. This effect was accompanied by reduced TRPV1 protein expression in the trigeminal spinal nucleus. Our results suggest that CBD and PECS-101 may benefit trigeminal neuralgia without motor coordination impairments. PECS-101 is more potent against the hypernociceptive and motor impairment induced by TN compared to CBD and carbamazepine. The antinociceptive effect of these cannabinoids is partially mediated by TRPV1 receptors in the caudal part of the trigeminal spinal nucleus, the first central station of orofacial pain processing.
<P>PROBLEM TO BE SOLVED: To provide a food composition containing collagen, and having function of promoting collagen synthetic efficiency in the body: and to provide a method for producing the food composition.  <P>SOLUTION: The food composition is obtained through the following process: steaming fresh olive leaves; rolling the steamed leaves; drying the rolled leaves; processing the dried leaves into powdery state; and mixing the powdery collagen and powdery olive leaves. At least one kind selected from vitamin C, hyaluronic acid, coenzyme Q-10, L-carnitine, chondroitin, acetylglucosamine, elastin and astaxanthin so as to produce powdery food composition. The olive leaves richly contain oleuropeine which is a kind of polyphenol. Intake of both the collagen and the oleuropeine at the same time enables favorable generation of the collagen regardless of the age of a person who takes the composition because the oleuropeine has effect of promoting collagen synthetic efficiency in the body.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
OBJECTIVES: The objective of this study is to evaluate whether there is an association between in-utero exposure to nicotine and subsequent hearing dysfunction.
MATERIALS AND METHODS: Secondary analysis of a multicenter randomized trial to prevent congenital cytomegalovirus (CMV) infection among gravidas with primary CMV infection was conducted. Monthly intravenous immunoglobulin hyperimmune globulin therapy did not influence the rate of congenital CMV. Dyads with missing urine, fetal or neonatal demise, infants diagnosed with a major congenital anomaly, congenital CMV infection, or with evidence of middle ear dysfunction were excluded. The primary outcome was neonatal hearing impairment in one or more ears defined as abnormal distortion product otoacoustic emissions (DPOAEs; 1 to 8 kHz) that were measured within 42 days of birth. DPOAEs were interpreted using optimized frequency-specific level criteria. Cotinine was measured via enzyme-linked immunosorbent assay kits in maternal urine collected at enrollment and in the third trimester (mean gestational age 16.0 and 36.7 weeks, respectively). Blinded personnel ran samples in duplicates. Maternal urine cotinine >5 ng/mL at either time point was defined as in-utero exposure to nicotine. Multivariable logistic regression included variables associated with the primary outcome and with the exposure (p < 0.05) in univariate analysis.
RESULTS: Of 399 enrolled patients in the original trial, 150 were included in this analysis, of whom 46 (31%) were exposed to nicotine. The primary outcome occurred in 18 (12%) newborns and was higher in nicotine-exposed infants compared with those nonexposed (15.2 vs. 10.6%, odds ratio [OR] 1.52, 95% confidence interval [CI] 0.55-4.20), but the difference was not significantly different (adjusted odds ratio [aOR] = 1.0, 95% CI 0.30-3.31). This association was similar when exposure was stratified as heavy (>100 ng/mL, aOR 0.72, 95% CI 0.15-3.51) or mild (5-100 ng/mL, aOR 1.28, 95% CI 0.33-4.95). There was no association between nicotine exposure and frequency-specific DPOAE amplitude.
CONCLUSION: In a cohort of parturients with primary CMV infection, nicotine exposure was not associated with offspring hearing dysfunction assessed with DPOAEs.
KEY POINTS: · Nicotine exposure was quantified from maternal urine.. · Nicotine exposure was identified in 30% of the cohort.. · Exposure was not associated with offspring hearing dysfunction..
The investigators will assess the effects of a year-long small process group intervention, led by a psychiatrist, which aims to improve self-awareness, mindfulness, and resilience in first and second-year medical students. Students self-select into the process group, and a similar number are randomly recruited as controls from the rest of the preclinical student body. The psychiatrist is blinded to student participation in the study. Students in the process and control groups will be surveyed with the Perceived Stress Scale, the Connor-Davidson Resilience Scale, and the Grit Scale in September 2023, and again after nine months and 25 sessions, in May 2024, after the academic year. Statistical analysis will be done with R Studio. Bandura's theory of self-efficacy was used to conceptualize the study. Recruitment is done by email, as is data collection. The intervention includes guided exploration of the psychodynamic process, group dynamic theory, cognitive behavioral therapy, dialectical behavioral therapy, boundaries, and empathy.
The present invention is directed to novel formulations of modified antibodies and to methods of producing the same. The modified antibodies formulated according to the present invention each comprise an antibody fragment covalently attached to at least one nonproteinaceous polymer, such as poly(ethyleneglycol). CDP870 is an example of one such modified antibody, a therapeutic modified antibody. One method disclosed herein involves the removal from a solution of the modified antibody of molecules capable of adversely affecting the stability or solubility of the modified antibody after lyophilization (e.g., by dialysis or diafiltration), followed by lyophilization of the modified antibody. Another method involves concentration of a modified antibody solution by equilibrium dialysis. The methods of the present invention can be used to produce formulations suitable for use in subcutaneous and parenteral injection, including high concentration formulations.
The invention discloses a cranial nerve activating and restoring liquid and belongs to the technical field of medicines. The cranial nerve activating and restoring liquid comprises plant nervonic acid, metallothionein MT3, menthol, camelina sativa seed oil, oil-soluble VB12, aspirin, oryzanol powder and rice oil. The nervonic acid and the metallothionein MT3 are adopted as main components, and reasonable auxiliary components are adopted as supplements. The auxiliary components can fully promote absorption of the nervonic acid and the metallothionein MT3 by human bodies and ensure function exertion of the nervonic acid and the metallothionein MT3. The cranial nerve activating and restoring liquid can be taken orally and absorbed through the intestinal tract or transdermal absorption through cerebral cortex tissues can be achieved through mist spraying at the outside of brain. The cranial nerve activating and restoring liquid is capable of activating and restoring rigidified deteriorative and deactivated brain cells, promoting brain development of children, improving the level of intelligence, improving brain functions of middle-young people, and inhibiting senile dementia and the Parkinson's disease, and has special effects on dizziness, brain swelling and hypomnesis which are caused by electric, magnetic and light radiation.
Patients in the experimental group were treated with the maximum tolerable dose of angiotensin converting enzyme inhibitor ( ACEI ) and / or angiotensin II receptor blocker ( ARB ) combined with rituximab. The specific usage and dosage are as follows : On the basis of the use of ACEI and / or ARB, rituximab was used on D1 and D31 days, 1 g each time, intravenous drip, twice in total. Add 1 g rituximab at 6 months. All patients who received rituximab were given oral acetaminophen ( 1g ), diphenhydramine hydrochloride ( 50mg ) and intravenous methylprednisolone ( 40mg ) 30-60min before the beginning of infusion. ACEI and / or ARB were given daily maximum tolerable dose according to individual factors of subjects.
INTRODUCTION: Cardiogenic shock is severe circulatory failure that results in significant in-hospital mortality, related morbidity, and economic burden. Patients with cardiogenic shock are at high risk for atrial and ventricular arrhythmias, particularly within the subset of patients with an overlap of cardiogenic shock and cardiac arrest.
AREAS COVERED: This review article will explore the prevalence, definition, management, and outcomes of common arrhythmias in patients with cardiogenic shock. This review will describe the pathophysiology of arrhythmia in cardiogenic shock and the impact of inotropic agents on increased arrhythmogenicity. In addition to medical management, focused assessment of mechanical circulatory support, radiofrequency ablation, deep sedation, and stellate ganglion block will be provided.
EXPERT OPINION: We will navigate the limited data and describe the prognostic impacts of arrhythmia. Finally, we will conclude the review with a discussion of prevention strategies, research limitations, and future research directions.
The invention provides an active chemical compound Anoectochilus roxburghii for anti self-body immune hepatitis and preparation method thereof. Through separations and purifications of the water extract of the Anoectochilus roxburghii plant, the chemical compound Anoectochilus roxburghii is obtained. Through assessments of the immune suppression for the chemical compound, the chemical compound is found to have cell activity suppression effect on T lymphocyte cells inside and outside the body. The chemical compound can be used as a lead compound for developing drug for treating self-body immune hepatitis. The experiment results show that the Anoectochilus roxburghii has good remedy effects for self-body immune hepatitis. The mechanism lies in that the chemical compound has good suppression functions for EGFR2 kinase. The chemical compound can effectively suppress the metabolism related tubes JAK2-STAT3 and inflammation related tubes PI3K-AKT.
This umbrella review of 34 meta-analyses, representing 235 randomised controlled trials done across 52 countries and 48 957 participants and ten chronic conditions, aimed to evaluate evidence on the efficacy of mobile phone interventions for populations with chronic diseases. We evaluated the strengths of evidence via the Fusar-Poli and Radua methodology. Compared with usual care, mobile apps had convincing effects on glycated haemoglobin reduction among adults with type 2 diabetes (d=0·44). Highly suggestive effects were found for both text messages and apps on various outcomes, including medication adherence (among patients with HIV in sub-Saharan Africa and people with cardiovascular disease), glucose management in type 2 diabetes, and blood pressure reduction in hypertension. Many effects (42%) were non-significant. Various gaps were identified, such as a scarcity of reporting on moderators and publication bias by meta-analyses, little research in low-income and lower-middle-income countries, and little reporting on adverse events.
Venetoclax and Azacitidine control arm in dose expansion. The participants will be randomized to the treatment arm or control arm at a 2:1 ratio.
Techniques for predicting, reporting and preventing medical adverse events such as sepsis are disclosed. For example, the techniques may be implemented in a client-server arrangement, where the client resides on a smartphone of a medical professional. The ability of the disclosed technology to detect an impending medical adverse event utilizes two innovations. First, some embodiments include a flexible and extensible joint model based on sparse multiple output gaussian processes. Unlike prior art joint models, the disclosed model can account for very challenging structures that include non-gaussian noise, while being scalable to large data. Second, some embodiments utilize an optimization strategy to predict events using the distribution of event occurrences estimated by the joint model.