anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present disclosure is related to a topical composition consisting of a formula based on cold cream, mineral oil, zinc oxide, triethanolamine and ionic silver. The present invention is used in the medical and pharmaceutical area, particularly in the infected skin wounds treatment of any type, grade and extension; such as burns, pressure ulcers, diabetic foot ulcer, venous ulcers, arterial ulcers, dehiscence, cutaneous abscesses, bites, oncological ulcers, etc. Compared with other products used in infected skin wounds, is highly compatible by the similarity of its physical composition, is non-occlusive allowing skin perspiration. The percentages and / or grammage are specific to maintain the physical and chemical characteristics of normal skin (Degree of humidity, pH) and eliminate the pathogenic microorganisms present in the infected wound, does not cause irritation, or sensitization to perilesional skin. This invention has an optimal stability against environmental factors to guar antee its conservation, presents inertia to the active principles, of creamy consistency so that its extension on the bed of the infected wound is easy and can be dispersed favoring, in general, the penetration of the composition. The present invention is a versatile chemical substance that has the following advantages: Having broad spectrum antimicrobial properties, eliminates more than 360 pathogens eliminating the infection in the affected area, and favors autolytic and enzymatic debridement of non-viable tissue allowing the phagocytic cells to liquefy the tissue and thus promote granulation, induces hydration in the application zone and maintains the vehicle / skin interface, due to the proteolytic enzymes in the wound bed, keeping it humid, providing an optimal environment; scientific evidence has shown that a wound in a humid environment heals in a shorter time than in a dry environment. (Winter 1962). This formulation implies fast, simple and economical technology.
Vitamin D-dependent rickets type 1A (VDDR1A) is a rare condition caused by biallelic pathogenic variants in CYP27B1, which encodes 25-hydroxyvitamin D3-1-α-hydroxylase. Inadequate activity of this enzyme results in deficient 1α-hydroxylation of inactive 25-hydroxyvitamin D to biologically active 1,25-dihydroxyvitamin D, with consequent adverse effects on calcium and phosphate metabolism. A female child was clinically diagnosed at 18 months old with hypophosphatemic rickets based on phenotype and biochemical testing, with neither parent affected. A subsequent affected male sibling led to the reconsideration of the diagnosis. Exome sequencing showed a homozygous CYP27B1 c.1040T>A (p.Ile347Asn) variant for both children. No variants were found in genes associated with hypophosphatemic rickets. A review of published cases of VDDR1A with homozygous CYP27B1 variants indicates variable clinical presentation, lack of genotype-phenotype correlation, and low serum phosphate at diagnosis in most cases. These findings emphasize the clinical importance of molecular testing as part of the diagnostic evaluation for cases of non-nutritional rickets.
Microbial infection-induced sepsis causes excessive inflammatory response and multiple organ failure. An effective strategy for the treatment of sepsis-related syndromes is still needed. Rosuvastatin, a typical β-hydroxy β-methylglutaryl-CoA reductase inhibitor licensed for reducing the levels of low-density lipoprotein cholesterol in patients with hyperlipidemia, has displayed anti-inflammatory capacity in different types of organs and tissues. However, its effects on the development of sepsis are less reported. Here, we found that the administration of Rosuvastatin reduced the mortality of sepsis mice and prevented body temperature loss. Additionally, it inhibited the production of inflammatory cytokines such as tumor necrosis factor (TNF-α), Interleukin-6 (IL-6), interleukin-1β (IL-1β), and migration inhibitory factor (MIF) in peritoneal lavage supernatants of animals. The increased number of mononuclear cells in the peritoneum of sepsis mice was reduced by Rosuvastatin. Interestingly, it ameliorated lung inflammation and improved the hepatic and renal function in the sepsis animals. Further in vitro experiments show that Rosuvastatin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory cytokines in RAW 264.7 macrophages by preventing the activation of nuclear factor kappa-B (NF-κB). Our findings demonstrate that the administration of Rosuvastatin hampered organ dysfunction and mitigated inflammation in a relevant model of sepsis.
PROBLEM TO BE SOLVED: To obtain a cosmetic having excellent bleaching actions by including an alkylresorcinol and a substance such as an extract of Betula platyphylla Sukatchev var. japonical Hara. SOLUTION: This cosmetic contains (A) an alkylresorcinol represented by the formula (R1 is a 1-7C alkyl) (preferably a 4-alkylresorcinol or 4-n- butylresorcinol) and/or its physiologically acceptable salt and (B) at least one kind of substance selected from the group consisting of an extract of Betula platyphylla Sukatchev var. japonica Hara, an extract of Engelhardtia chrysolepis H. and a water-soluble soybean protein. Furthermore, the ingredient B is preferably obtained by adding a solvent, e.g. ethanol in an amount of 1-20 times that of an original crude drug or its processed material thereto and carrying out the dipping, etc., for several days in the case of room temperature. The amount of the formulated ingredients based on the total amount of the objective cosmetic are preferably 0.01-10 wt.% of the ingredient A and 0.01-10 wt.% of the ingredient B.
Nearly 85% of stroke survivors experience significant unilateral impairment in upper extremity motor control, typically caused by damage to the corticospinal (CST) and corticoreticular (CRT) tracts (i.e., the corticofugal tracts). Alternative neural pathways, such as the contralesional cortico-reticulospinal tract (CRST), can be recruited to achieve movement of the affected arm and hand, but may have undesirable consequences. For example, the diffuse, bilateral branching of reticulospinal neurons can produce abnormal muscle co-activations (synergies) in the paretic limb, and involuntary mirror movements (associated reactions) between limbs. Together, these effects create stereotypical movement patterns post-stroke, and there is growing interest in novel \"anti-synergy\" interventions to enhance usage of residual CST systems rather than strengthening the CRST. Imaging has the potential to become an invaluable tool for evaluating whether rehabilitative strategies can preferentially access CST versus CRST pathways. However, current functional imaging research has focused on cortical activity, and must theoretically infer what pathway is used. Structural MRI directly assesses changes in white matter pathways, but it is limited to detecting long-term plasticity. To guide new interventions, there is a critical need to directly evaluate what descending motor pathways are active during movement. Thus, the overall objective of this study is to generate a novel fMRI dataset in participants with post-stroke hemiparesis, capturing neural activity during an innovative isometric shoulder abduction task, evaluating differences when abducting the paretic versus non-paretic arm. The investigators will acquire multi-echo fMRI data in individuals with post-stroke hemiparesis and age-matched controls, hypothesizing that increased reliance on the CRST will cause distinct activation patterns during shoulder abduction with the paretic limb, and that this will correlate with individual upper-extremity impairment (Upper-Extremity Fugl-Meyer Assessment). This work is significant because it will provide direct evidence of descending contralesional motor pathway involvement in post-stroke hemiparesis, and demonstrate the utility of neuroimaging for optimizing movements to preferentially engage specific systems and promote desired neural plasticity following injury.
An epilepsy diagnosis reduces a patient's quality of life tremendously, and it is a fate shared by over 50 million people worldwide. Temporal lobe epilepsy (TLE) is largely considered a nongenetic or acquired form of epilepsy that develops in consequence of neuronal trauma by injury, malformations, inflammation, or a prolonged (febrile) seizure. Although extensive research has been conducted to understand the process of epileptogenesis, a therapeutic approach to stop its manifestation or to reliably cure the disease has yet to be developed. In this review, we briefly summarize the current literature predominately based on data from excitotoxic rodent models on the cellular events proposed to drive epileptogenesis and thoroughly discuss the major molecular pathways involved, with a focus on neurogenesis-related processes and transcription factors. Furthermore, recent investigations emphasized the role of the genetic background for the acquisition of epilepsy, including variants of neurodevelopmental genes. Mutations in associated transcription factors may have the potential to innately increase the vulnerability of the hippocampus to develop epilepsy following an injury-an emerging perspective on the epileptogenic process in acquired forms of epilepsy.
An image generation device generates continuous image data from successive medical examination images. An encoding device compresses the image data by using a prediction process. An evaluation unit evaluates physiological periodic data regarding repetition rate related to the data. A ring buffer memory stores the compressed image data. The encoding device is connected to evaluation unit which controls encoding device by adjusting prediction process relative to current period length of physiological periodic data. An independent claim is also included for continuous image data compressing method.
The study aimed to evaluate and compare patency rate and complications of standard arteriovenous grafts (SAVGs) and immediate-access arteriovenous grafts (IAAVGs) in end stage renal disease (ESRD) patients for one year after the intervention. Patients were randomly divided into two groups: SAVGs group and IAAVGs group. Patients with ESRD with no chance for native AVF were examined clinically and by duplex ultrasonography preoperatively. Follow up was for one year. Primary end points were the success rate, complications rate (hematoma, pseudo-aneurysm, graft site infection, systemic bacteremia), time of first cannulation. Secondary end points were primary and secondary patency within one year.
Method for separately regulating hepatic and extrahepatic production and insulin-like growth factor-1 (IGF-1). The levels of IGF-1 in sera can be significantly reduced without reducingt the desired actions of IGF-1. This is achieved by separately regulating the systemic and local distribution of IGF-1 without affecting body growth. The invention also relates to the treatment of obesity. It further refers to the treatment of retinopathy in diabetic patients. Inhibition of the biological effects exerted by IGF-I in blood circulation could be obtained by injection of IGF-I antagonists, IGF binding proteins, or thyrohostins into blood circulation or by blockade of hepatic IGF-I information, for instance by oral treatment with estrogenic agents or by local treatment with small nucleotide molecules.
<P>PROBLEM TO BE SOLVED: To obtain a fat accumulation-suppressing composition which exerts excellent fat accumulation-suppressing effect by directly acting on a fat cell and also has no limit in flavoring.  <P>SOLUTION: This fat accumulation-suppressing composition contains a modified grape fruit oil in which limonene of 10-100 mass% is removed from the fruit oil. Alternatively, the composition contains an extract from the grape fruit oil by a mixed solvent comprising n-hexane/ethyl acetate of 9:1. In this invention, there are disclosed the composition-containing skin care preparation for external use, slimming cosmetic, obesity improver, clothes and foods. Further, there is provided a fat accumulation-suppressing method comprising application of the composition to the skin.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
CLOBEX® (clobetasol propionate) Spray, 0.05% should be sprayed directly onto the affected skin areas twice daily and rubbed in gently and completely. Do not exceed 30 sprays per application or 60 sprays per day. (See INDICATIONS AND USAGE).

CLOBEX® (clobetasol propionate) Spray, 0.05% contains a super-high potent topical corticosteroid; therefore treatment should be limited to 4 weeks. Treatment beyond 2 weeks should be limited to localized lesions of moderate to severe plaque psoriasis that have not sufficiently improved after the initial 2 weeks of treatment with CLOBEX® (clobetasol propionate) Spray, 0.05%.

The total dosage should not exceed 50 g (59 mL or 2 fluid ounces) per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

Therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

Use in pediatric patients younger than 18 years is not recommended because of the potential for HPA axis suppression. (See PRECAUTIONS: Pediatric Use).

Unless directed by physician,CLOBEX® (clobetasol propionate) Spray, 0.05% should not be used with occlusive dressings.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a role in IPF but the exact mechanisms are yet to be elucidated. In this study, we have utilized various perturbations of the bleomycin mouse model of IPF including genetic knockout, RANKL inhibition, and macrophage adoptive transfer to further understand ACP5's role in pulmonary fibrosis. Genetic ablation of Acp5 decreased immune cell recruitment to the lungs and reduced the levels of hydroxyproline (reflecting extracellular matrix-production) as well as histological damage. Additionally, gene expression profiling of murine lung tissue revealed downregulation of genes including Ccl13, Mmp13, and Il-1α that encodes proteins specifically related to immune cell recruitment and macrophage/fibroblast interactions. Furthermore, antibody-based neutralization of RANKL, an important inducer of Acp5 expression, reduced immune cell recruitment but did not decrease fibrotic lung development. Adoptive transfer of Acp5-/- bone marrow-derived monocyte (BMDM) macrophages 7 or 14 days after bleomycin administration resulted in reductions of cytokine production and decreased levels of lung damage, compared to adoptive transfer of WT control macrophages. Taken together, the data presented in this study suggest that macrophage derived ACP5 plays an important role in development of pulmonary fibrosis and could present a tractable target for therapeutic intervention in IPF.
Glycine is an amino acid and a nonelectrolyte. A solution of glycine in water is therefore nonconductive and suitable for urologic irrigation during electrosurgical procedures. A 1.5% concentration of glycine in water (200 mOsmol/liter calc.) is sufficient to minimize the risk of intravascular hemolysis which can occur from absorption of plain water through open prostatic veins during transurethral resection (TUR). It is hypotonic in relation to the extracellular fluid (280 mOsmol/liter). Any solution absorbed intravascularly during transurethral prostatic or bladder surgery, although variable in amount depending primarily on the extent of surgery, will be excreted by the kidney. Studies have shown that the absorption of glycine does not cause significant hemolysis (increase of free hemoglobin) or release significant amounts of free ammonia in the blood. Glycine is rapidly degraded in the liver by glycine oxidase.

Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production).

Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium.
In cooperation with a first database, a problem preparation supporting unit supports the preparation of nursing problem items for patients. Based on the nursing problem items prepared, a plan preparation supporting unit supports the preparation of nursing care plans by conducting search through a second database. In cooperation with a third database, a specification unit specifies an implementation of nursing items contained in the prepared nursing care plan. When a communication unit receives an implementation result of the nursing items, the communication unit outputs the result to a recording unit. A nurse enters an evaluation of the implementation result of the nursing items to an operation apparatus. The evaluation entered is recorded in the recording unit. Among the nursing problem items stored in the recording unit, the nursing items contained in the nursing care plans, the implementation results and the evaluations, the management unit associates them with one another by bringing them into correspondence with each other.
BACKGROUND: Rates of pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer have improved, especially among human epidermal growth factor 2-positive (HER2+) and triple-negative subtypes. The frequency and significance of biomarker profile change in residual disease are unclear. This study aimed to determine the rate of biomarker profile changes after NAC and the impact on clinical outcomes in a contemporary cohort.
METHODS: Upon institutional review board approval, the study identified 634 consecutive patients treated with NAC between 2010 and 2022 at two academic institutions. The study cohort was focused on patients with residual disease who underwent biomarker profile retesting. Biomarker profile change for each subtype was compared across groups using Fisher-Irwin tests. Cox Proportional Hazards Model and Kaplan-Meier plots were performed to evaluate the association of changed versus unchanged biomarker profile with event-free survival.
RESULTS: Biomarker retesting was performed for 259 (61.4 %) of 422 patients with residual disease. Biomarker profile change occurred in 18.1 % overall and was significantly higher among those with pre-NAC HER2+ disease (32.7 %, 17/52) than among those with HER2-disease (14.5 %, 30/207) (p = 0.004). Conversion of pre-NAC biomarker profiles of HR+HER2- and HR+HER2+ to triple-negative breast cancer (TNBC) post-NAC may be associated with worse event-free survival, hazard ratios of 2.23 (95 % confidence interval [CI], 0.90-5.53; p = 0.08), trending toward significance, and 36.7 (95 % CI, 2.2-610.8; p = 0.01), respectively.
CONCLUSIONS: The results from one of the largest contemporary cohorts demonstrated that biomarker profile change in patients with residual disease after NAC was common. Furthermore, specific biomarker profile change in residual disease may have prognostic value. These findings strengthen the rationale for routine re-testing of biomarkers in residual disease after NAC.
Parent-Based Prevention (PBP; Sadeh-Sharvit \& Lock, 2018) is a manualized preventive intervention, focused on increasing parental awareness and competence to facilitate healthy eating habits, body image, and self-regulation in children whose parent has an eating disorder history. PBP is comprised of three phases that focus on unique goals. The strategies in each session include psycho-education, behavioral experiment planning, and skill practicing to augment parents' insight into how the context of the parental cognitions and behaviors may impact child outcomes, with the goal of creating a longstanding effect.
This is an exploratory study of single-arm, open, modified "3+3" dose escalation. The BGT007H cell therapy group received five progressively increased dose levels (2.0× 10\^8,5.0 ×10\^8, 1.0× 10\^9,3.0 × 10\^9,6.0 ×10\^9) of BGT007H cells. Each subject was observed for at least 4 weeks after cell transfusion (DLT observation period). The first two dose groups (2.0×10\^8 cells and 5.0×10\^8 cells) included 1 subject each, and the other three dose groups were followed by conventional "3+3" dose increments.
A topical cosmetic composition for increasing skin whitening or lightening is described. The composition includes a pomegranate extract in an amount effective to reduce melanin composition. The pomegranate extract may be standardized to about 20% punicalagin. The composition may also include an extract from the genus  larix,  such as  Larix sibirica.  The  larix sibirica  may be standardized to 80% taxifolin. A method for using the compositions is described.
Breastfeeding protects children against diseases such as gastrointestinal, asthma, diabetes, otitis media, sudden infant death syndrome and obesity. At the same time, it supports the increase of children's IQ level and brain development. Among the benefits for women's health are its contribution to the involution process in the postpartum period, protection against postpartum depression, ovarian and breast cancer. The social impact of breastfeeding is that it provides economic benefits.Despite all the benefits of breastfeeding, breastfeeding rates are not sufficient. Globally, the rate of exclusive breastfeeding of children for the first six months is 41%, and the rate of breastfeeding with complementary foods for two years is 45%.

There are many factors that affect breastfeeding. These; social, environmental, cultural and personal factors. These factors can affect the motivation of women internally and externally.For this reason, internal and external motivations of women will be supported with breastfeeding education.
Use aseptic technique when preparing and administering sterile irrigation solutions.

Use only if solution is clear and container and seal are intact.

If pain or hematuria should occur during irrigation, it should be discontinued and the patient reevaluated.

When used for irrigation via appropriate irrigation equipment, the administration set should be attached promptly. Unused portions should be discarded and a fresh container of appropriate size used for the start up of each cycle or repeat procedure. For repeated irrigations of urethral catheters, a separate container should be used for each patient.