anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Interferon fixed to a support so that the interferon acts on the exterior of the cell without penetrating and effecting the pathological processing taking place within the cell is characterised in that the support is (a) a homopolysaccharide chosen from D-fructose polymers esp. laevosan (main link beta-2, 6-D-fructosyl-D-fructose), D-mannose polymers esp. mannan (main linkage: alpha-1,2, alpha-1,3 and alpha-1,6-D-mannosyl -D-mannose), D-galacturonate polymers esp. pectin (main linkage: alpha-1, 4-D-galacturonosyl-D-galacturonate), pentose polymers esp. xylan (main linkage : beta-1,4-D-xylosyl-D-xylose), D-galactose polymers esp. galactan (main linkage; beta-1,4-D-galactosyl-D-galactose) (b) a heteropolysaccharide containing modified sugars esp. powdered agarose (main linkage : beta-1,4-D-galactosyl-D-galactose), heteropolysaccharides containing substd. sugars esp. glycerol-pectate (main linkage : that of pectin) and derivatives containing more than one type of monosaccharide residue esp. heparin (main linkage alpha-1, 4-D-2-deoxy-2-sulphoamino-glucosyl-6-sulphate-D-Glucuronate) Antivval, treatment of certain forms of cancer and leukemia. When bonding in this way the interferon is not degraded by the cell and can be used in much smaller amounts. The supports are soluble or may be solubilised and the interferon may be administered by normal routes. The interferon is pref. fixed to a support activated by diazotisation esp. by the method of S.A. Barker et al (Immunology (72 23 689). Insoluble supports with fixed interferon may be solubilised by various treatments e.g. Sepharose (RTM) with fixed interferon may be hydrolysed by heating in an autoclave under 1 atmosphere and 110 degrees C for 39 mins at pH2.
An object is to provide an ophthalmic aqueous liquid preparation excellent in the retention of gatifloxacin in a tear fluid and the penetration of gatifloxacin into an aqueous humor and a conjunctiva. Another object is to prevent the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation. An aqueous liquid preparation comprising gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the salt and at least 0.15 w/v% of xanthan gum enables to improve the retention and penetration of gatifloxacin. When at least 0.2 w/v% of sodium chloride is added to the aqueous liquid preparation, the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation can be prevented. Disclosed is a polycarbonate resin composition containing a glass filler, which is excellent in transparency, strength and heat resistance, while having high flame retardancy. Also disclosed is a polycarbonate resin molded article obtained by molding this resin composition. Specifically disclosed is a flame-retardant polycarbonate resin composition containing a combination of (A) 55-95% by mass of an aromatic polycarbonate resin and (B) 45-5% by mass of a glass filler having a refractive index difference of 0.002 or less from the aromatic polycarbonate resin, and further containing per 100 parts by mass of the combination, (C) 0.05-2.0 parts by mass of a silicone compound having a reactive functional group and (D) 0.03-0.4 part by mass of an organic alkali metal salt compound and/or an organic alkaline earth metal salt compound. Also disclosed is a polycarbonate resin molded article having a thickness of 0.3-10 mm which is obtained by molding the composition. An object is to provide an ophthalmic aqueous liquid preparation excellent in the retention of gatifloxacin in a tear fluid and the penetration of gatifloxacin into an aqueous humor and a conjunctiva. Another object is to prevent the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation. An aqueous liquid preparation comprising gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the salt and at least 0.15 w/v% of xanthan gum enables to improve the retention and penetration of gatifloxacin. When at least 0.2 w/v% of sodium chloride is added to the aqueous liquid preparation, the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation can be prevented.
PURPOSE:An adhesive plaster obtained by incorporating a plaster consisting of an adhesive material with nulumbinic fructus or/and Nupharis Rhizome. CONSTITUTION:An adhesive plaster obtained by incorporating a plaster consisting of an adhesive material, e.g. acrylic material such as n-butyl acrylate, or rubber based material such as styrene-isoprene-styrene block copolymer rubber, with nelmbinis fructus (fruit of Nelumbo nuifera Gaertn. of the family Mymphaeaceae or/and Nupharis Rhizome (rhizome of Nuphar japonica DC. belonging to the above-mentioned family) in an amount of 0.05-20wt% for dried powder and 0.005-20wt% for extract. A tackifier, e.g. terpenic resin, adhesive force and holding power modifier, e.g. liquid paraffin or wax, filler, e.g. titanium oxide, may be incorporated as the third component. Since a compound containing phenolic hydroxyl group, amine based compound, etc., reduce considerably the content thereof among the drug to be incorporated, this plaster is particularly useful for formulating the above-mentioned drug.
The exercise protocol would last 5 weeks, performing 3 exercise sessions per week, with an effective work time of 30 minutes per session. The exercises would be directly focused on activating the core stabilizing muscles.
Objectives Cardiac rehabilitation (CR) provides evidence-based secondary prevention for people with heart disease (HD) (clients). Despite HD being the leading cause of mortality and morbidity, CR is under-utilised in Australia. This research investigated healthcare systems required to improve access to CR in rural and remote areas of North Queensland (NQ). Methods A qualitatively dominant case study series to review management systems for CR in rural and remote areas of NQ was undertaken. Data collection was via semi-structured interviews in four tertiary hospitals and four rural or remote communities. An audit of discharge planning and CR referral, plus a review of community-based health services, was completed. An iterative and co-design process including consultation with healthcare staff and community members culminated in a systems-based model for improving access to CR in rural and remote areas. Results Poorly organised CR systems, poor client/staff understanding of discharge planning and low referral rates for secondary prevention, resulted in the majority of clients not accessing secondary prevention, despite resources being available. Revised health systems and management processes were recommended for the proposed Heart: Road to health model, and given common chronic diseases risk factors it was recommended to be broadened into Chronic disease: Road to health . Conclusion A Chronic disease: Road to health model could provide effective and efficient secondary prevention for people with chronic diseases in rural and remote areas. It is proposed that this approach could reduce gaps and duplication in current healthcare services and provide flexible, client-centred, holistic, culturally responsive services, and improve client outcomes.
FIELD: medicine, particularly, methods of removing toxic and pathogenic components from human organism and other warm-blooded. SUBSTANCE: this method prescribes administering sorptive materials into intestinal lumen in order to accelerate process of withdrawal of toxic agents and preventing intestinal mucosa from absorbing salts of heavy metals and pathogenic microorganisms from adhering to intestinal mucosa surface. Disclosed m method particularly prescribes administering such natural dispersing materials as montmorillonite or clinoptilolite into intestinal lumen in amount of 0.7 to 10.0 g per 1 cu. dm of intestine contents (0.1 to 1.0 g per 1 kg of body mass 24 h). EFFECT: effective withdrawal of toxic agents. 10 tbl
Defined as women between 18 and 30 years old, who are vaccinated against HPV with either the Cervarix, Gardasil or Gardasil9 vaccine and are using contraceptives that do not affect ovulation (i.e. intrauterine devices).
Military training and operations present a risk of incapacitation and death from Exertional Heat Illness (EHI). However, widely accepted EHI risk factors are absent in almost half of all United Kingdom (UK) military EHI cases, indicating that a significant number of EHI cases in military personnel involve alternative risk factors. Risk factors for EHI can been classified along a spectrum ranging from acute (e.g. recent poor sleep) to chronic (e.g. low fitness), with the role of chronic risk factors supported by the observation that individuals who have suffered an EHI are at a substantially increased risk of subsequent EHI. The primary aim of this study is to compare putative 'chronic' EHI risk factors (e.g. composition of gastrointestinal (GI) microbiome, infection and inflammation, trait-like psychological factors) between a cohort who have suffered a history of EHI and a control cohort with no EHI history. The secondary aim is to examine the influence of these EHI risk factors on thermoregulation during a standard heat tolerance assessment.
OBJECTIVE: To understand the implications of a tiered extracorporeal membrane oxygenation (ECMO) criteria framework and the outcomes of patients with COVID-19 acute respiratory distress syndrome who we were consulted on for ECMO but ultimately declined.
METHODS: All patients declined for ECMO support by a large regional health care system between March 2020 and July 2021 were included. Restrictive selection criteria were enacted midway through the study stratifying the cohort into 2 groups. Primary outcomes included 30-day mortality. Secondary outcomes included reasons for declining ECMO and survival stratified by phase.
RESULTS: One hundred ninety-three patients with COVID-19 acute respiratory distress syndrome were declined for ECMO within the study period out of 260 ECMO consults. At the time of consult, 71.0% (n = 137) were mechanically ventilated and 38% (n = 74) were proned and chemically paralyzed. Thirty-day mortality was 66% (n = 117), which increased from 53% to 73% (P = .010) when restrictive criteria were enacted. Patients with multisystem organ failure, prolonged ventilator time, and advanced age had respectively an 11-fold (odds ratio, 10.6; 95% CI, 1.7-65.2), 4-fold (odds ratio, 3.5; 95% CI, 1.1-12.0), and 4-fold (odds ratio, 4.4; 95% CI, 1.9-10.2) increase in the odds of mortality.
CONCLUSIONS: Patients with COVID-19 acute respiratory distress syndrome declined for ECMO represent a critically ill cohort. We observed an increase in the severity of disease and 30-day mortality in consults in the latter phase of our study period. These findings may reflect our use of tiered selection criteria coupled with ongoing education and communication with referring centers, sparing both patients likely to respond to medical therapy and those who were unsalvageable by ECMO.
Diphosphonic acids of formula (I), where R is H or CH3, and their water-soluble salts are new: (I) are prepd. by reacting NH2CHR.COOH with H3PO3 and PCl3, followed by acid hydrolysis of the reaction mixt. (I) are chelating agents useful for preventing Ca pptn. in water, as corrosion inhibitors; for cleaning metal or glass; to overcome unwanted effects of Cu ions (e.g. to stabilise per cpds., fats and soaps); to bind metal ions in dye baths; to introduce trace elements into plants; and as additives for cyanide electroplating baths. They are also used for control of Ca and phosphate metabolic disorders (e.G. orally at 1-50 mg/kg/day or for animals as feed additives opt. together with calcitonin) and in oral hygiene to prevent development of calculus. (I) can also be used to make 99m-Tc diagnostic agents specific for the skeleton and Ca-contg. tumours.
Soybean rust is an economically significant disease caused by the fungus Phakopsora pachyrhizi that negatively impacts soybean (Glycine max [L.] Merr.) production throughout the world. Susceptible plants infected by P. pachyrhizi develop tan-colored lesions on the leaf surface that give rise to funnel-shaped uredinia as the disease progresses. While most soybean germplasm is susceptible, seven genetic loci (Rpp1 to Rpp7) that provide race-specific resistance to P. pachyrhizi (Rpp) have been identified. Rpp3 was first discovered and characterized in the soybean accession PI 462312 (Ankur), and it was also determined to be one of two Rpp genes present in PI 506764 (Hyuuga). Genetic crosses with PI 506764 were later used to fine-map the Rpp3 locus to a 371-kb region on chromosome 6. The corresponding region in the susceptible Williams 82 (Wm82) reference genome contains several homologous nucleotide binding site-leucine rich repeat (NBS-LRR) genes. To identify Rpp3, we designed oligonucleotide primers to amplify Rpp3 candidate (Rpp3C) NBS-LRR genes at this locus from PI 462312, PI 506764, and Wm82 using polymerase chain reaction (PCR). Five Rpp3C genes were identified in both Rpp3-resistant soybean lines, and co-silencing these genes compromised resistance to P. pachyrhizi. Gene expression analysis and sequence comparisons of the Rpp3C genes in PI 462312 and PI 506764 suggest that a single candidate gene, Rpp3C3, is responsible for Rpp3-mediated resistance. [Formula: see text] The author(s) have dedicated the work to the public domain under the Creative Commons CC0 "No Rights Reserved" license by waiving all of his or her rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law, 2024.
1420713 Immuno-suppressive anti-human lymphocyte serum CHOAY SA 5 Feb 1974 [8 Feb 1973] 05205/74 Heading A5B Immuno-suppressive anti-human lymphocyte serum, free from anti-erythrocyte and antithrombocyte effects may be prepared by injecting an animal with an antigenic material comprised of the acellular supernatant of cultures of cells of long-term lines initiated from human lymphocytes and preferably cultured without receiving information other than that which is naturally specific to them, or of one or more fractions of said supernatant, which antigenic material causes the immunisation of the animal, and bleeding the treated animal and recovering the serum from the plasma separated from the collected blood. Each culture may be obtained from a single cell line. Preferably the serum comprises anti-human lymphocyte immunoglobulins G obtained by purification of the serum. The antigenic material used for immunising the animal may be prepared by seeding a suitable nutrient medium with long term line cells initiated from human lymphocytes and cultured without receiving information other than that which is naturally specific thereto, continuing the culture until the cell count has reached a value corresponding substantially to saturation of the medium employed, stopping the culture at this stage, centrifuging the culture and retaining the supernatant which constitutes the antigenic material. The anti-human lymphocyte immunoglobulins G are preferably isolated by purification of the blood plasma obtained after immunisation caused by injection of the supernatant utilising an acridine salt e.g. 2-ethoxy-6, 9-diamino acridine lactate, followed by a purification operation using ammonium sulphate and passage over an anion exchanger resin having a high fixation capacity, at a pH of from 6.5 to 8.5, and sterilisation of the thus-obtained solution.
The proposed research aims to establish the efficacy of an imagined gait protocol for improving gait and cognition in the elderly. This imagined gait protocol involves imagined gait in single (imagined walking; iW) and dual-task (imagined walking while talking; iWWT) situations. A single-blind randomized clinical trial of 58 cognitively-healthy elderly with pre-post measures of gait, cognition, and functional Magnetic Resonance Imaging (fMRI) during imagined gait is proposed. The overall hypothesis is that imagined gait can be used as a rehabilitative tool for improving gait and cognition in the elderly because it engages and strengthens similar neural systems as actual gait and cognition. The first aim of this study is to establish the efficacy of our imagined gait protocol to improve gait and cognition in the elderly. We predict that our imagined gait intervention will improve gait velocity during actual walking and walking-while-talking conditions to a greater extent than the active control (visual imagery) intervention. We also predict that our imagined gait intervention will cognitive performance during dual-task walking conditions. The second aim of this study is to determine neuroplasticity changes in response to our imagined gait protocol. We predict that the neural systems engaged during imagined gait will change following our imagined gait intervention.
Participants received 10 milligrams/killograms (mg/kg) dose of isavuconazonium sulfate every 8 hours (± 2 hours) on days 1 and 2 for a total of 6 doses (via intravenous or oral administration at the investigator's discretion) followed by once-daily maintenance dose of 10 mg/kg for up to 84 days IA or 180 days IM or until the participant had a successful outcome as judged by the investigator, whichever occured first. The route of administration could have been changed per the investigator's discretion.
The epitranscriptome encompasses over 170 post-transcriptional modifications found in various RNA species. RNA modifications play pivotal roles in regulating gene expression by shaping RNA structure and function, implicating the epitranscriptome in diverse biological processes, including pathology progression. This review focuses on research elucidating the roles of the epitranscriptome in cancer metastasis. Metastasis, a primary cause of solid tumor patient mortality, involves a multistep process whereby tumor cells migrate from a primary tumor to distant secondary organs. We discuss RNA modifications found on rRNA, tRNA, and mRNA, highlighting their roles in different stages of metastasis. Understanding mechanisms by which modifications regulate molecular and cellular processes during metastasis is crucial for leveraging epitranscriptomic signatures in cancer diagnosis and treatment.
BACKGROUND: Oncogenic human papillomavirus (HPV) types are linked to anal cancer, with elevated risk among men who have sex with men (MSM), especially men with HIV. Data on HPV-related malignancies in the Middle East and North Africa (MENA) region is scarce. This study aims to assess anal HPV strains, dysplasia, and sexually transmitted infections (STIs) among asymptomatic MSM with HIV in Lebanon.
METHODS: We conducted a cross-sectional study with 38 participants who completed questionnaires on socio-demographics, HIV-related data, and STI history. Anoscopy, anal Pap smears, and PCR for HPV and STIs were performed.
RESULTS: HPV was detected in 34 of 38 samples (89%), with 91% having multiple strains. HPV16 was the most common strain (56%). Eighteen percent had a concomitant bacterial anal STI. Most participants lacked awareness of anal dysplasia and cancer risk, with only 29% vaccinated against HPV.
CONCLUSION: This study highlights high HPV prevalence and low awareness among men with HIV in Lebanon. The findings underscore the need for improved HPV education, vaccination, and routine screening in this population. Further research is needed to address barriers to comprehensive HIV and STI care in the region.
In the noninvasive-ventilation group is delivered to the patient through a face mask that was connected to an ICU ventilator,with pressure support applied in a noninvasive ventilation mode. The Fio2 or PEEP level (or both) were then adjusted to maintain an Spo2 of 92% or more.
In period 1, subjects will receive a single oral dose of savolitinib on Day 1 after overnight fasting. Following minimum 10 days of washout after the last dose of savolitinib, in period 2 subjects will take oral doses of fluvoxamine alone, twice daily from Days 1 to 4. On Day 5 subject will receive a single oral dose of savolitinib and a twice daily oral dose of fluvoxamine. On Day 6, subjects will receive a twice daily oral dose of fluvoxamine alone.
This study features a single treatment arm where participants receive semaglutide (Fitaro) for weight management. Administered subcutaneously once weekly, the treatment begins at 0.25 mg and escalates to a maximum of 2.4 mg over 16 weeks based on individual response and tolerance. Participants include overweight or obese adults aged 18 and older, with or without Type 2 Diabetes Mellitus (T2DM). The primary focus is to assess the efficacy and safety of semaglutide in achieving significant weight loss, while also evaluating its impact on metabolic parameters like body mass index (BMI), waist circumference, blood glucose levels, and overall quality of life. Alongside medication, participants will receive lifestyle counseling to encourage dietary adjustments and increased physical activity. Regular follow-up assessments will be conducted to monitor weight loss progress, metabolic health, and any treatment-related adverse events throughout the study duration.
BACKGROUND: The upper cervical dorsal root ganglia (DRG) are important for the transmission of sensory information associated with the back of the head and neck, contributing to head pain. Calcitonin receptor (CTR)-based receptors, such as the amylin 1 (AMY1) receptor, and ligands, calcitonin gene-related peptide (CGRP) and amylin, have been linked to migraine and pain. However, the contribution of this system to nociception involving the cervical DRG is unclear. Therefore, this study aimed to determine the relative distribution of the CTR, CGRP, and amylin in upper cervical DRG.
METHODS: CTR, CGRP, and amylin immunofluorescence was examined relative to neural markers in C1/2 DRG from male and female mice, rats, and human cases. Immunofluorescence was supported by RNA-fluorescence in situ hybridization examining amylin mRNA distribution in rat DRG.
RESULTS: Amylin immunofluorescence was observed in neuronal soma and fibres. Amylin mRNA (Iapp) was also detected. Amylin and CGRP co-expression was observed in 19% (mouse), 17% (rat), and 36% (human) of DRG neurons in distinct vesicle-like neuronal puncta from one another. CTR immunoreactivity was present in DRG neurons, and both peptides produced receptor signalling in primary DRG cell cultures. CTR-positive neurons frequently co-expressed amylin and/or CGRP (66% rat; 84% human), with some sex differences.
CONCLUSIONS: Amylin and CGRP could both be local peptide agonists for CTR-based receptors in upper cervical DRG, potentially acting through autocrine and/or paracrine signalling mechanisms to modulate neuron function. Amylin and its receptors could represent novel pain targets.
The hormone of the corpus luteum is concentrated by treating a solution containing the hormone in a solvent immiscible with water with one or more adsorbing agents and extracting the hormone from the adsorbent by means of an organic solvent.  Carbon disulphide, petroleum ether, benzene, toluene and ethyl acetate may be used as the solvent immiscible with water, suitable adsorbents are fuller's earth, alumina, fibrous alumina, kieselguhr, silica gel, kaolin, calcium carbonate, carbon.  For extracting the hormone from the adsorbent suitable solvents are ether, methyl or ethyl alcohol, acetone, chloroform or a mixture, e.g. of methyl alcohol and petroleum ether.  The extraction of the adsorbent is made at raised temperature.  After evaporation of the solvent the concentrated product is left in solid form or as a liquid which solidifies on standing.