anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To provide a foamable bath agent free from the flotation of an inorganic pigment by adding the inorganic pigment coated with the mixture of a nonionic surfactant with an oil to a foamable bath agent containing an organic acid and a carbonate salt and/or a bicarbonate salt. CONSTITUTION:A foamable bath agent containing a carbonate salt and/or a bicarbonate salt and an organic acid is compounded with 1-10-wt.% of an inorganic pigment (e.g. titanium dioxide) coated with the mixture of an oil (e.g. jujube oil, perfume) with one or more of nonionic surfactants represented by formula I, formula II (R<1> is 1-20C alkyl, 1-20C alkylene), formula III (R<2> is 1-20C alkyl, 1-20C alkylene), etc. The mixing weight ratio of the nonionic surfactant/the oil is preferably 25-80/75-20, and the amount of the surfactant-oil mixture coated on the surfaces of the inorganic pigment is 1-20wt.% based on the inorganic pigment. When applied to a bathtub, the foamable bath agent has good foamability and does not cause the flotation of the inorganic pigment on the surface of the hot water, thereby facilitating the cleaning of the bathtub.
The study of ideological asymmetries in empathy has consistently yielded inconclusive findings. Yet, until recently these inconsistencies relied exclusively on self-reports, which are known to be prone to biases and inaccuracies when evaluating empathy levels. Very recently, we reported ideological asymmetries in cognitive-affective empathy while relying on neuroimaging for the first time to address this question. In the present investigation which sampled a large cohort of human individuals from two distant countries and neuroimaging sites, we re-examine this question, but this time from the perspective of empathy to physical pain. The results are unambiguous at the neural and behavioral levels and showcase no asymmetry. This finding raises a novel premise: the question of whether empathy is ideologically asymmetrical depends on the targeted component of empathy (e.g., physical pain vs cognitive-affective) and requires explicit but also unobtrusive techniques for the measure of empathy. Moreover, the findings shed new light on another line of research investigating ideological (a)symmetries in physiological responses to vicarious pain, disgust, and threat.
Subjects will undergo a 4-week titration phase during which doxazosin may be increased to a maximum dose of 10mg at bedtime based on symptoms and tolerability. After the 4-week titration phase, subjects will continue at stable dose of study medication for a 4-week stable dose phase.
The disease course of liver cirrhosis is associated with a progressing dysbiosis of the intestinal microbiome and systemic inflammation, that leads to the development of cirrhosis-associated immune dysfunction (CAID). In healthy individuals, the microbiome uses orally incorporated dietary fibers for the production of short-chain-fatty-acids (SCFA). One of these physiological short-chain-fatty acids is propionate. SCFA´s are essential for a maintained integrity of the intestinal barrier and promote anti-inflammatory effects. Due to a reduction of symbiotic gut bacteria and an elevated number of potentially pathogenic microbes in cirrhosis, diminished levels of SCFA can be observed in this group of patients. Consequently, the permeability of the gut barrier increases and a bacterial translocation results. This translocation is a main driver of systemic inflammation and is linked to a higher likelihood for infections, such as spontaneous bacterial peritonitis (SBP). Furthermore, systemic inflammation promotes the degradation of skeleton muscles (sarcopenia) and frailty. Both are associated with a poor prognosis in cirrhosis. However, the impact of an adapted diet, that intends to normalize the intestinal SCFA-levels, on the clinical outcome of patients with advanced liver disease, needs to be further evaluated.

Therefore, the included patients receive dietary counseling, supplemented with propionate, that functions as fiber-surrogate. The dietary-intervention will last for a period of two months.
Intubation with the GlideScope® video-laryngoscope and styletted the tracheal tube using manufacturer's GlideRite Rigid Stylet (GRS) (GVL - ST1; Verathon Medical Inc., Bothell, WA, USA). Time till successful intubation of the patient is calculated.
PROBLEM TO BE SOLVED: To provide the subject composition useful for the photodynamic therapy of psoriasis and consisting of a topically administrable stable gel containing zinc phthalocyanine, a specific carrier and a gelling gent. SOLUTION: The objective composition contains (A) zinc phthalocyanine, (B) (i) a monoalkyl ether of diethylene glycol free from N-alkylpyrrolidone, N-dialkylbenzamide and dimethyl sulfoxide or a mixture of the component (i) and (ii) a lipid and (C) a gelling agent (preferably hydroxypropyl cellulose). The component (ii) is preferably a mixture of palmitoyloleyl phosphatidylcholine and dioleyl phosphatidylserine. The amount of the component A is preferably 50-400 μg based on 1 mL of the component B and that of the component C is usually 0.1-10 pts.wt. based on 100 pts.vol. of the composition.
ABSTRACT      The invention relates to a new strain of rabies virus no. 675, a sample of which was deposited with the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under number CNCTC AO 4/77, to a process for the isolation of the virus strain, to new living or inactivated cell culture vaccines prepared from this new virus strain, to processes for the preparation of novel vaccines and to methods for immunization of warm blooded animals using such vaccines.    Vaccines derived from this new strain can be administered by different routes and especially non-parenterally e.g. by the oral route, they provide a full protection when administered before or after a rabies infection.    Moreover the live virus vaccine does not multiply after administration and no residual virus can be detected, while the vaccines cause very rapid interferon production and other additional, unknown interfering properties e.g. cellular-mediated immunity.
Participants in this arm will be offered 10 home visits in a 12-month period from community health workers (CHWs). Visits will cover a core asthma curriculum and provide social support.
Treatment seeking smokers across both Alabama and South Carolina (N=544) will be recruited and consented through established online methods and randomized to receive a 4-week course of either varenicline or combination NRT (patch + lozenge), counterbalanced. Using a concrete and measurable indicator of early treatment success (3 days non-smoking), smokers demonstrating early success at 4 week follow-up will continue with another four weeks of same medication, either varenicline or combination NRT. Those who do not demonstrate early success will be randomized to a subsequent 4-week course of either a) continuation of same medication, or b) switch to the other FDA approved option, either varenicline or combination NRT. The same process will repeat at Week 8, wherein treatment responders will continue with their ongoing medication and non-responders will be randomized to a final 4-week course of either a) continuation of same medication or b) switch to an e-cigarette. End of treatment outcomes will be assessed at Week 12 at which time no more product will be offered. Final follow-up at Week 24 will ascertain all primary (cessation) and secondary outcomes.
PURPOSE: To obtain a pasting agent having high percutaneous absorptivity and percutaneous stability of indomethacin in a pasting base agent, having excellent antiphlogistic and analgesic action and high safety to the skin. CONSTITUTION: This pasting agent contains a pasting base material, indomethacin in the amount of 0.1-2wt.% of the total base agent, 1-10wt.% crotamiton and 0.5-30wt.% a 4-6C dihydric alcohol (e.g.; 1,3-butylene glycol). The pasting base agent is pasted on a substrate to obtain the objective pasting agent. In this case, a tacky adhesive used in the pasting base agent is made of water-based, an acrylic-based, rubber-based, a silicone resin-based, etc., and has an adhesive strength capable of fixing on the surface of skin at a normal temperature for a long time. Percutaneous absorptivity of indomethacin conventionally inferior to the absorptivity is increased and its pharmacological action is exhibited at the maximum.  In the case of oral administration, indomethacin inducing adverse effect such as digestive organs disease can be effectively percutaneously administrated directly to a patient part.
This multi-center, unblinded, prospective randomized controlled trial will enroll adult diabetic patients of the Wilson Community Health Center, Harvest Family Health Center, and Freedom Hill Community Health Center living below 200% of 2013 poverty level with a serum hemoglobin A1C \>9% and who currently own a mobile device with text messaging capacity. After written informed consent has been obtained, subjects will be randomized to intervention or control group (1:1), stratified based on insulin initiation within 1 week of study inclusion. Participants randomized to the intervention group will be further divided into subgroups as "insulin user" or "non-insulin user" and both will receive SMS messages every 7 days. The content of the message consist of medication reminders, reporting of blood glucose results, insulin technique assessment (if applicable), or d) medication adherence assessment. Participants will be asked to respond with a simple text within 7 days. The intervention group will receive the standard medical appointment reminder via telephone one to two business days prior to the appointment at the Health Center PLUS a unidirectional text message two business days prior to scheduled health center appointments. Control group participants will receive the standard medical appointment reminder via telephone one to two business days prior to the appointment at the health center. All participants in the study (control and intervention) will undergo venipuncture at 3 months (+/-) 2 weeks for the determination of hemoglobin A1C. Demographic information, and frequency of hemoglobin A1C concentrations in the past 6 months will be assessed at baseline. Each week for 12 weeks, the number of texts sent per week and by type, percent of respondents weekly by text or by phone, content of participant responses, number of patients unable to be reached via text, total investigator time spent per week, and time spent per contact will be recorded. At the three month visit, the hemoglobin A1C concentration, blood transfusions since study initiation, and medication changes will be recorded.
Intracranial xanthogranulomas (XGs) have been found at various sites, but xanthogranuloma of the sellar region is extremely rare. We report about a case of sellar XG in a 34-year-old female. Magnetic resonance imaging showed a solid-cystic mass located at the sella turcica. The cystic component was hyperintense on the T1-weighted image (WI) and T2WI. The solid component was hyperintense on T1WI and hypointense on T2WI. There was peripheral enhancement after gadolinium administration. The diagnosis of cystic macroadenoma was considered before surgery. Final diagnosis of XG was confirmed by histopathological examination after surgical resection. Gross total resection of the lesion was achieved using the microscope through endoscopic endonasal transsphenoidal approach. The patient had a good outcome and no symptom of diabetes insipidus, hormonal evaluation did not show any alterations compatible with hypopituitarism and prolactin levels were normal XG should receive diagnostic consideration for the sellar mass lesions with cystic components hyperintense on T1WI and T2WI, solid components hyperintense on T1WI and hypointense on T2WI, and CT without evidence of calcifications. It is important to consider the possibility of XG when pertinent, as it facilitates a proper surgical approach strategy.
Compositions, methods, kits and apparatus are provided for delivering a macromolecular assembly such as a plasmid, virus vector, or other gene vector, to an extravascular tissue such as muscle tissue. The composition comprises the macromolecular assembly and a vascular permeability-enhancing agent. In another embodiment, the composition further comprises a vasodilating agent.  The method of the invention comprises proving a vascular permeability-enhancing agent to a blood vessel and providing a macromolecular assembly to the vessel. An oxygenator useful for providing oxygen to a fluid extracorporeally prior to providing the fluid to a blood vessel of a mammal is included in the invention. Kits, apparatus, and methods for using the catheters described herein for isolating cardiac ciruclation, diverting caval blood flow from the right atrium, and other purposes, are also described.
FIELD: medicine. ^ SUBSTANCE: invention relates to field of medicine and deals with composite materials for plastic reconstruction of damaged bone tissues. Obtained is porous composite chitosan-gelatin sponge containing octacalcium phosphate in form of powder or granules. Introduction of gelatin increases sponge plasticity, which makes it possible to fill in bone defects of various form and size, as well as increases sponge solubility. ^ EFFECT: octacalcium phosphate contained in sponge demonstrates osteoinductive properties, which in combination with chitosan creates favourable conditions for formation of natural human bone tissue. ^ 1 tbl, 9 ex
BACKGROUND: The long-term prognosis of baseball and softball players diagnosed with Little League elbow (LLE) and Little League shoulder (LLS) is unknown. Many of these athletes are potentially at risk of developing future shoulder and elbow injuries that may require surgical intervention. This study's purpose is to retrospectively assess 5-year patient-reported outcomes and career progression of a series of youth baseball and softball players diagnosed with LLE and LLS.
METHODS: This institutional review board-approved, single-center, retrospective study evaluated 5-year outcomes of a cohort of youth baseball and softball players diagnosed with LLE and LLS between 2013 and 2017. Demographic and clinical data was recorded including age, gender, primary position, and months played per year. A standardized phone survey was obtained approximately 5 years post-treatment to assess upper extremity function, career progression, and pain recurrence.
RESULTS: Sixty-one patients (44 LLE, 17 LLS) met the inclusion criteria and participated in a standardized phone survey. The mean age at the time of diagnosis was 13.2 years and all but one of the athletes were male. On average, about 80% (34/44 LLE, 15/17 LLS) played baseball 9 months or more per year. After diagnosis and nonoperative management, more than 80% (37/44 LLE, 14/17 LLS) were able to return to competition, but up to 40% of players changed positions (9/44 LLE, 7/17 LLS). Five years later, less than half (21/44 LLE, 8/17 LLS) were playing baseball actively. The recurrence rate was >20% (9/42 LLE, 6/17 LLS) with a mean time of recurrence of 8.8 months. Patients who experienced symptom recurrence were less likely to play baseball 5 years later and had lower patient-reported outcomes.
CONCLUSIONS: A diagnosis of LLE and LLS in early adolescence can be a setback for a young athlete. Fortunately, most athletes will be able to return to competition with ∼50% still competing at 5 years. Very few will progress to future arm surgery, but recurrence rates are relatively high, and these athletes are less likely to participate in their sport 5 years later.
LEVEL OF EVIDENCE: Level IV-Retrospective cohort study.
PURPOSE:To produce a large amount of interferon, by separating the animal cells from the culture liquid after the production of interferon, and using the cells repeatedly for the production. CONSTITUTION:Animal cells such as leukocyte, lymphoblast, etc. are induced by an inducing agent by conventional method to produce interferon. The cell is treated with a treating agent such as sodium butyrate, dimethyl sulfoxide, etc. preferably prior to the treatment with the inducing agent, separated and recovered from the culture liquid when the titer of the interferon reaches the peak or thereabout, and suspended again in a fresh medium to produce the interferon. The cells are again separated and recovered from the liquid, and the process is repeated.
This will be a Randomized Clinical Trial that will be conducted at Pakistan Sports Board and Coaching Centre, Lahore. Participants of the study are 38 that will be randomly allocated into 2 groups. The group A will perform Pilates three times per week for 6 weeks and group B will follow Plyometric training three times per week for 6 weeks. Participants of both groups will follow their regular warm up regime and nutrition plans. All participants will undergo a pre and post treatment test via Functional movement's screen test (FMST), vertical-jump test (VJT), 30m sprint test, sit and reach test. The data will be analyzed via SPSS version 21.

Key Words: Performance; Pilates; plyometric; sprint; volleyballVolleyball is one of the famous games which is used in order to enhance and increase physical and game oriented skills in athletes and players. The main goal of athletic training and sports participation is to enhance athletic performance. Different types of training regimes (Pilates and Plyometric) are used on athletes to increase their physical performance. As volleyball is the game of power agility as well as speed. Physical fitness is one of the important parameters of this game. So, Pilates training strengthens the deep core muscles and improves movement, efficiency and muscle control. And plyometric training is to increase the power of subsequent movements using both natural elastic components of muscle and tendon and the stretch reflex. The aim of this study is to compare the effects of Pilates and Plyometric, on physical performance of volleyball players.

This will be a Randomized Clinical Trial that will be conducted at Pakistan Sports Board and Coaching Centre, Lahore. Participants of the study are 38 that will be randomly allocated into 2 groups. The group A will perform Pilates three times per week for 6 weeks and group B will follow Plyometric training three times per week for 6 weeks. Participants of both groups will follow their regular warm up regime and nutrition plans. All participants will undergo a pre and post treatment test via Functional movement's screen test (FMST), vertical-jump test (VJT), 30m sprint test, sit and reach test. The data will be analyzed via SPSS version 21.

Key Words: Performance; Pilates; plyometric; sprint; volleyball
CD44 is associated with a high risk of metastasis, recurrence, and drug resistance in various cancers. Here we report that platelet endothelial aggregation receptor 1 (PEAR1) is a CD44 chaperone protein that protected CD44 from endocytosis-mediated degradation and enhances cleavage of the CD44 intracellular domain (CD44-ICD). Furthermore, we found that lysyl oxidase-like protein 2 (LOXL2), an endogenous ligand of PEAR1, bound to the PEAR1-EMI domain and facilitated the interaction between PEAR1 and CD44 by inducing PEAR1 Ser891 phosphorylation in a manner that was independent of its enzyme activity. Levels of PEAR1 protein and PEAR1 phosphorylation at Ser891 were increased in patients with triple-negative breast cancer (TNBC), were positively correlated with expression of LOXL2 and CD44, and were negatively correlated with overall survival. The level of PEAR1 Ser891 phosphorylation was identified as the best independent prognostic factor in TNBC patients. The prognostic efficacy of the combination of PEAR1 phosphorylation at Ser891 and CD44 expression was superior to that of PEAR1 phosphorylation at Ser891 alone. Blocking the interaction between LOXL2 and PEAR1 with monoclonal antibodies significantly inhibited TNBC metastasis, representing a promising therapeutic strategy for TNBC.
Disinfecting agents containing heavy metals, which cause release of respective ions (mercury, zinc, copper, etc.) should not be used for skin or mucous membrane disinfection since they have been related to incidents of swelling and edema.

When chemical disinfection of the container surface is desired, either isopropyl alcohol (91%) or ethyl alcohol (70%) is recommended. It is recommended that chemical disinfection be accomplished by wiping the vial stopper thoroughly with cotton or gauze that has been moistened with the recommended alcohol just prior to use. When a container is required to have a sterile outside, a Sterile-Pak should be chosen. Glass containers may, as an alternative, be autoclaved once. Stability has been demonstrated using a targeted F0 of 7 minutes at 121°C.

The solubility of ropivacaine is limited at pH above 6. Thus, care must be taken as precipitation may occur if ropivacaine hydrochloride injection is mixed with alkaline solutions. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Solutions which are discolored or which contain particulate matter should not be administered.
The present invention relates to a method for diagnosing a brain disease utilizing 3D magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). The method for diagnosing a brain disease comprises the following steps. An image obtaining unit obtains the 3D MRI and MRA photographing a brain of a patient. A brain disease lesion extraction unit extracts a lesion region and lesion information of a brain disease from the MRA. An image mapping unit maps the lesion region to the 3D MRI based on the extracted lesion information. A classification unit localizes the mapped region and classifies a disease.
FIELD: medicine. SUBSTANCE: method involves injecting sterile personal antigen material obtained from inflammation focuses of otorhinolaryngologic organs. The preparation is intramuscularly administered at a dose of 0.5 ml containing 2 billions of microbe substance in 1.0 ml and intracutaneously 0.5 ml containing 2 millions of microbe substance every other day. The total treatment course involves 5 intramuscularly and 5 intracutaneous injections simultaneously. EFFECT: enhanced effectiveness of treatment. 4 tbl