anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the technical field of polypeptides, and discloses a polypeptide and a preparation method and application thereof. The amino acid sequence of the polypeptide is Asp-Trp-Phe. The polypeptides were subjected to solid phase synthesis using standard Fmoc protocol. The polypeptide of the invention is docked with BACE1 enzyme related to A beta generation in Alzheimer disease by molecular docking technology, and the molecular docking result shows that the polypeptide of the invention can enter the hydrophobic cavity of the BACE1 enzyme and interact with the active site thereof to inhibit the activity of the BACE1 enzyme. In addition, the polypeptide DWF with different concentrations can obviously reduce the aggregation of A beta after being preincubated for 24 hours (p < 0.05). The polypeptide can be used as an adjuvant therapy medicament for Alzheimer's disease or a functional health-care food or a medicine with the function of reducing the aggregation of Abeta, and has the potential of improving and slowing the progress of diseases.
Magnesium is the fourth most abundant mineral in the human body. It is critical to day-to-day physiological function including the regulation of metabolism, cardiovascular function, immune function, and the operation of the nervous system. In light of its important role in physiology, dietary supplementation of magnesium has been purported to improve athletic performance, although the precise mechanism is unclear. The foci of the proposed study is the ergogenic effects of magnesium, its potential influence on gut health, and its potential ability to improve skeletal muscle function. The investigators will be studying an athletic/competitive population of endurance-trained adults. This group is likely to be the most interested in the use of magnesium to enhance athletic performance. Also, by only recruiting habitual exercisers, the variability between participants is likely to be reduced compared with if the investigators had also recruited people who are usually sedentary.
Indole, a compound in Chinese stinky tofu (ST), acts as a ligand for the aryl hydrocarbon receptor (AHR). Despite extensive research on prebiotic compounds, indole's specific role in ST remains unexplored. This study used an ethanol gavage method to create an ALD (alcoholic liver disease) mouse model and investigate dietary indole's effects on the intestinal barrier. Our findings indicate that after 6 weeks of being fed ST, the indole present (2 mg/day) robustly activated the intestinal AHR, upregulating its target gene, CYP1A1 (cytochrome P450 1A1 enzyme). This activation significantly reduced intestinal permeability, mitigated alcohol-induced oxidative stress and inflammation, and restored intestinal barrier function. Consequently, the study demonstrates that foodborne indole substantially reduces alcohol absorption and lowers the expression levels of liver inflammation-related factors, thereby slowing the progression of ALD. These results highlight indole's therapeutic potential for treating ALD and its role in developing functional foods.
Patients receive placebo PO BID and standard chemotherapy for 6 -8 cycles. Treatment with placebo continues for up to 2 years in the absence of disease progression or unacceptable toxicity.
Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution contains dorzolamide, a sulfonamide, and timolol maleate, a beta-adrenergic blocking agent; and although administered topically, is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulfonamides and/or systemic administration of beta-adrenergic blocking agents may occur with topical administration. For example, severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol maleate (see CONTRAINDICATIONS). Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Sensitization may recur when a sulfonamide is readministered irrespective of the route of administration. If signs of serious reactions or hypersensitivity occur, discontinue the use of this preparation.
A traditional Chinese herb medicine paste for treating intestine and stomach disease is composed of egg and fresh ginger. For each therapeutic course 4000 gm. egg and 18 gm. fresh ginger is used, its making method is as follows: after egg 13 cooked, remove shell and egg white, egg yolk is ground and stir fried in iron pot until charred and give out oily liquid, stop heating, cooling the oily material, put in a container and ready for use. The fresh ginger is chopped into small particles, put in above mentioned container and soak for 24 hrs. to obtain the invented medicine. It is high in curing rate and has no toxic side effect.
Sjögren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. Defining core disease domains comprising both specific clinical features and incorporating the patient experience is a critical first step to define this complex disease. The OMERACT SjD Working Group held its first international collaborative hybrid meeting in 2023, applying the OMERACT 2.2 filter toward identification of core domains. We accomplished our first goal, a scoping literature review that was presented at the Special Interest Group held in May 2023. Building on the domains identified in the scoping review, we uniquely deployed multidisciplinary experts as part of our collaborative team to generate a provisional domain list that captures SjD heterogeneity.
PURPOSE:To provide a basic cosmetic lotion capable of constantly keeping the skin of the face, etc. in a smooth state, and preventing the wrinkling with age, easily at a low cost, by filtering boiled soup of soybean, adding MgSO4 to the liquid, adding ethanol and further benzoic acid to the mixture, stirring and sealing the mixture and leaving the product in a cool dark place. CONSTITUTION:Proper amount of washed soybeans are immersed in water for definite time interval, crushed finely, mixed with water, boiled, and filtered with a piece of cloth. The filtrate is added with MgSO4, stirred, and filtered with a white cloth to obtain the stock solution. The stock solution is mixed with proper amounts of ethanol, glycerol, boric acid powder, oxydol and burnt alum, stirred, added with a small amount of benzoic acid after 10 days, stirred, sealed, and left for about 1 month in a dark and cool place to obtain the objective cosmetic lotion. EFFECT:Effective to supply proteins and replenish the skin with sedum secreted from the sebum gland and lost by washing the face and hands. It smoothens the surface of the face, hands and foot constantly, and facilitates the application of cosmetics to the face.
A process and set-up of therapeutic immunomodulation is provided for medicine. Many illnesses (i.e. Sepsis) are, among other things, characterized by a disruption of the immune system. In spite of previous therapies using antibiotics, the mortality rate is still very high. The administration of individual cytokins has not yet resulted in any convincing results. The use of cells in an extra-corporal circulation that can adsorb or self-release immunomodulatory effect substances is a completely new type of complex therapeutic approach to such illnesses, which leads to an improvement in the health of the affected patients.
Long term survivors of childhood cancer, are a distinct group requiring specific follow-up in order to enhance their quality of life. Studies have shown that many of these patients will go on to develop chronic issues within different organ systems. Because of the iron burden of the frequent transfusions required to care for these patients, iron overload may indeed be one of the problems these survivors potentially face. Research primarily in thalassemia and bone marrow transplant patients who were extensively transfused has shown that iron overload can have a significant impact on their overall health. Complications from increased iron burden can include growth retardation, gonadal dysfunction, hypothyroidism, impaired glucose metabolism, cardiac arrhythmias and failure, hepatic fibrosis and cirrhosis, and increased susceptibility to infections. However all of these conditions related to iron overload can be prevented with the use of either phlebotomy or chelation therapy. Based on this knowledge, our objective is to determine if pediatric oncology and transplant patients heavily supported with transfusions develop consequential biochemical and clinical evidence of iron overload.
BACKGROUND: Endoscopic nasobiliary drainage (ENBD) is used as a drainage technique in patients with choledocholithiasis after stone removal. However, ENBD can cause discomfort, displacement, and other complications. This study aims to evaluate the safety of not using ENBD following elective clearance of choledocholithiasis.
METHODS: Relevant studies were identified by searching PubMed, Web of Science, EMBASE, EBSCO, and Cochrane Library from their inception until August 2023. The main outcomes assessed were postoperative complications and postoperative outcomes. Subgroup analyses were conducted based on study design types and treatment procedures.
RESULTS: Six studies, including three randomized controlled trials (RCTs) and three cohort studies, were analyzed. Among these, four studies utilized endoscopic techniques, and two employed surgical methods for choledocholithiasis clearance. The statistical analysis showed no significant difference in postoperative complications between the no-ENBD and ENBD groups, including pancreatitis (RR: 1.55, p = 0.36), cholangitis (RR: 1.81, p = 0.09), and overall complications (RR: 1.25, p = 0.38). Regarding postoperative outcomes, the subgroup analysis indicated that the bilirubin normalization time was longer in the no-ENBD group compared to the ENBD group in RCTs (WMD: 0.24, p = 0.07) and endoscopy studies (WMD: 0.23, p = 0.005), although the former did not reach statistical difference. There was also no significant difference in the length of postoperative hospital stay between the groups (WMD: -0.30, p = 0.60).
CONCLUSION: It appears safe to no- ENBD after elective clearance of choledocholithiasis.
Current vascular access options require frequent interventions. In situ tissue engineering (TE) may overcome these limitations by combining the initial success of synthetic grafts with long-term advantages of autologous vessels by using biodegradable grafts that transform into autologous vascular tissue at the site of implantation. Scaffolds (6 mm-Ø) made of supramolecular polycarbonate-bisurea (PC-BU), with a polycaprolactone (PCL) anti-kinking-coil, are implanted between the carotid artery and jugular vein in goats. A subset is bio-functionalized using bisurea-modified-Stromal cell-derived factor-1α (SDF1α) derived peptides and ePTFE grafts as controls. Grafts are explanted after 1 and 3 months, and evaluated for material degradation, tissue formation, compliance, and patency. At 3 months, the scaffold is resorbed and replaced by vascular neo-tissue, including elastin, contractile markers, and endothelial lining. No dilations, ruptures, or aneurysms are observed and grafts are successfully cannulated at termination. SDF-1α-peptide-biofunctionalization does not influence outcomes. Patency is lower in TE grafts (50%) compared to controls (100% patency), predominantly caused by intimal hyperplasia. Rapid remodeling of a synthetic, biodegradable vascular scaffold into a living, compliant arteriovenous fistula is demonstrated in a large animal model. Despite lower patency compared to ePTFE, transformation into autologous and compliant living tissue with self-healing capacity may have long-term advantages.
A Caralluma extract and a method of making thereof which can be standardized and reproducible, and which prevents the glycosides from decomposition, which can reduce the undesirable non-glycoside components. In the first Caralluma extract, the resinous material does not exceed 0.5% by weight, and, in the second Caralluma extract, the resinous material does not exceed 1.0% by weight. The first extract is produced by optionally pretreatment of plant materials, optional crushing and/or grinding, extraction, and concentration. The filtration step and the resin removal step may be performed optionally. The second extract is produced by contacting the first Caralluma extract with excipients, drying, powdering, sifting and blending. The Caralluma extracts of the present invention can be used for medical purposes and as food additives.
BACKGROUND: Chronic kidney disease (CKD) affects over 10 % of the global population and can lead to kidney failure and death. Exposure to per- and polyfluoroalkyl substances (PFAS) is associated with increased risk of CKD, yet studies examining the mechanisms linking PFAS and kidney function are lacking. In this exploratory study, we examined longitudinal associations of PFAS exposure with kidney function, and tested if associations were mediated by altered gut bacterial taxa or plasma metabolites using a multi-omics mediation analysis.
METHODS: Seventy-eight young adults from the Children's Health Study were included in this longitudinal cohort study. At baseline, seven plasma PFAS and untargeted plasma metabolomics were measured using liquid chromatography/mass-spectrometry. Baseline gut bacterial abundance was characterized using 16S rRNA sequencing and examined at the genus level. At follow-up, serum creatinine and cystatin-C concentrations were quantified to estimate glomerular filtration rate (eGFR). High-dimensional multi-omics analyses were conducted to assess the association between baseline PFAS exposure with follow-up eGFR, mediated by gut microbiome and circulating metabolite levels.
RESULTS: PFAS burden score, a variable developed to estimate exposure to chemical mixtures, was associated with kidney function. Each standard deviation increase in baseline PFAS burden score was associated with a 2.4 % lower eGFR at follow-up (95 % CI:[0.1 %,4.8 %]). Following high-dimensional mediation analyses with the microbiome and circulating metabolites, a joint component (characterized by reduced Lachnospiraceae and 17b-estradiol and increased succinate, retinoate and dodecanoic acid) and a metabolite component (characterized by increased hypotaurine and decreased D-pinitol and ureidopropionate) mediated 38 % and 50 % of the effect between PFAS burden score and eGFR, respectively.
CONCLUSION: Our proof-of-concept analysis provides the first evidence that reduced short-chain fatty acid-producing bacteria and anti-inflammatory metabolites may link PFAS exposure with impaired kidney function. This study raises the possibility of future targeted interventions that can alter gut microbiome or circulating metabolite profiles to prevent PFAS induced kidney damage.
The invention provides Yao-national tea powder for strengthening spleen and ventilating. The tea powder is a powdered composition mixed by the following medicinal materials in parts by weight: 1-2 parts of schisandra chinensis, 0.2-2 parts of caulis akebiae, 0.2-2 parts of paederia scandens, 0.2-2 parts of delavay honeysuckle herb, 0.2-2 parts of phryma leptostachya and 0.2-2 parts of caulis sargentodoxae, and is added with one or more of esliptae herba, spatholobus suberctu, syntriandrium (illigera rhodantha hance) and lygodium japonicum. The preparation method comprises the following steps: respectively grinding the medicinal materials which are clean without insect pests and dry without mildew into raw medicinal powders for later use; uniformly mixing the raw medicinal powders according to the proportion to obtain a composition; quantitatively encapsulating the composition with a non-woven fabric or a gauze bag to obtain a standard medicinal packet; and performing microwave sterilization treatment on the medicinal packet to obtain a finished product. When the Yao-national tea powder is used, the medicinal packet is cooked in boiling water for 3-5 minutes or directly brewed with boiling water to drink as tea, and is taken before Yao-national bath to improve the efficacy of Yao-national bath. The tea powder has the effects of strengthening spleen, ventilating, promoting digestion, slimming body, reducing body weight, soothing channels, activating collaterals, lowering blood fat and blood pressure, dispelling the effect of alcohol and the like, and has a remarkable curative effect on dry stool and constipation, drainage difficulty, anal fissure in defecation, haemorrhoids, irregular menstruation, enterogastritis, liver injury and the like. The tea powder is prepared from pure herbal medicinal materials, does not contain chemical preparations, and is non-toxic and harmless.
While life expectancy has increased markedly for people living with HIV (PLWH), gains in expected years of life have come at a cost - earlier onset and greater frequency of age-associated comorbid conditions, such as osteoporosis, metabolic syndrome, and cardiovascular disease. Accumulated multi-morbidity is the likely cause of much higher than age-expected rates of frailty in PLWH. Perceived stress is prevalent in PLWH and, when present, associated with worse clinical outcomes, including poor engagement in HIV care, rapid progression to AIDS, and higher AIDS-related mortality. Stress is a well-documented risk factor for many illnesses that demonstrate early onset in PLWH, and perceived stress has been hypothesized to be a cause of aging itself. Nonetheless, the role of perceived stress in early-onset aging and age-related illness in PLWH is essentially unexplored. Investigating the interrelatedness of aging, perceived stress, and HIV may elucidate mechanism(s) that underlie a phenotype of premature aging and functional decline in HIV patients with implications for understanding fundamental mechanisms of stress and aging in HIV uninfected populations. The proposed randomized controlled study will estimate correlations between perceived stress and both aging and HIV-specific outcomes and will measure feasibility of a cell phone-delivered stress reduction intervention. Participants will complete structured interviews to measure cumulative life stress, perceived stress, intimate partner violence exposure (as a traumatic stressor), functional status, frailty, and potential covariates across the age spectrum in PLWH. Stress measures will be correlated with biomarkers known to be associated with functional decline in aging, HIV-uninfected populations. The findings from this exploratory R03, led by a New Investigator, will measure feasibility of mobile technology for stress reduction interventions and estimate correlations between perceived stress and markers of aging and HIV disease. The results will be used to determine sample sizes necessary to perform definitive studies to assess the link between perceived stress and a phenotype of premature aging, as well as interventional studies of stress modification to mitigate the onset of early multi-morbidity and functional decline. These findings can be applicable to both HIV-infected and HIV-uninfected populations.
The invention discloses a novel momordica saponin extraction technology. The physical separation process for extraction of momordica saponin by water or ethanol as an extraction solvent does not produce harmful materials and realizes clean production. The water extraction agent saves a large amount of an organic solvent. The innocuous and unpoisonous water or ethanol extraction agent reduces damage to momordica saponin physiological activity, improves product quality and reduces environmental pollution. The novel momordica saponin extraction technology utilizes easily available raw materials and has a low manufacturing cost. The product can improve immunity, resist mutagenesis and viruses, reduce cholesterol and blood sugar and resist tumors and HIV. The momordica saponin product can be used as a raw material of many medical preparations. The momordica saponin product can be mainly used for adjusting human physiological functions, improving human immunity, inhibiting tumors, resisting oxidation and diminishing inflammation. The raw material formula of the technology comprises fresh momordica charantia, deionized water, ethanol with a concentration of 70% and petroleum ether.
PURPOSE:To provide a new isoquinoline derivative whichc is an agonist having high affinity and selectivity to delta-opioid recepter and useful as an immunosup pressive agent and analgesic. CONSTITUTION:A compound of formula I [R1 is H, 1-5C alkyl, etc,; R2 is H or OR5 (R5 is H or 1-5C alkanoyl); R3 and R3' are 1-5C alkyl, nitro, etc.; R4 is H, benzyl, etc.; X is CH or N[or its salt, e.g. 2-methy-4aalpha-(3-hydroxyphenyl)-8- methyl-1,2,3,4,4a,5,12,12abeta-octahydro-quinoxalino]2,3-g]isoquinoline. The compound of formula I wherein R1 is CH3, R2 is H and X is N can be produced by reacting a compoudn of formula II with a compound of formula III, successively subjecting the reaction product to cyclization and reduction, reacting the resultant compound of formula IV with a compound of formula V, successcively deprotecting and oxidizing the reaction product to obtain a compound of formula VI, condensing the compound to a compound of formula VII and reducing the condensation reaction product.
Infants 9 months of age in Stage 2 (Africa), part of the safety cohort, randomized to receive three doses of altSonflex1-2-3 Dose B vaccine, one each at Day 1, Day 85 and Day 253. These infants also receive two doses of Serum Institute of India's Measles and rubella vaccine, one each at Day 29 and Day 281, as concomitant vaccination.
Contains sodium sulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

There is the potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other NSAIDs. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs.

With some NSAIDs, there exists the potential for increased bleeding time due to interference with platelet aggregation. There have been reports that ocularly applied NSAIDs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.
Pouchitis is the most common long term complication among patients with ulcerative colitis who have undergone restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). The etiology of pouchitis remains unclear. There is significant clinical evidence implicating bacteria in the pathogenesis. It has been shown that fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile -infection. Case reports have also shown promising results of FMT in patients with inflammatory bowel disease. Currently there is no established effective treatment for chronic antibiotic dependent or refractory pouchitis. The aim of our study is to investigate the efficacy and safety of fecal transplantation in the treatment of chronic pouchitis instead of antibiotic therapy. Another aim is to evaluate phylogenetic analysis of the fecal microbiota trying to find microorganisms contributing to good results in fecal transplantation in IPAA patients.

Patients receive FMTs on weeks 0 and 4. Antibiotic treatment has been stopped 36 hours before the first FMT.