anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Disclosed are methods for evaluating genetic models that are predictive of autoimmune disease phenotype or status. The methods comprise obtaining genotype data from bone marrow transplant recipients and donors. The autoimmune disease phenotype of the transplant recipient after the transplantation may be used evaluate the effect of genotype on the autoimmune disease. Phenotype comparisons may be made to the transplant donor and/or the transplant recipient prior to the transplantation. The methods may be used to validate genetic models associated with autoimmune disease. The genetic models may be based on one or more genetic variants associated with susceptibility to or protection from an autoimmune disease.
PURPOSE: A polymer for cancer cell therapy and an atmospheric pressure plasma apparatus are provided to diagnose cancer with only polymer of gold nanoparticle and to remove side effects and pain. CONSTITUTION: A polymer used in treating cancer cells is formed by binding of a metal nanoparticle with a primary antibody to antigen of cancer cells. The metal nanopaticle is a gold nanoparticle of a diameter of 30nm. The primary antibody is FAK(focal adhesion kinase). The polymer further contains a secondary antibody on which a fluorescence material is conjugated. A plasma apparatus which is used in treating cancer cell by irradiating plasma to the cancer cells comprises: a first cable having a first electrode and a first insulator surrounding the same, a second cable having a secondary electrode and a second insulator surrounding the same, and a powder supply unit for generating plasma.
The control group will not be given any training. Diet and brisk walking 3 days a week will be recommended by the doctor as routine treatment for the control group.
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition. Women are recommended to do at least 150 minutes of moderate-intensity aerobic activity a week during pregnancy and the postpartum period. Exercise both during and out of pregnancy has been shown to be an effective non-pharmacologic tool to reduce glucose and lipid profiles. The goals and purpose of this pilot study is to 1) determine the influence of exercise and the timing of exercise surrounding a meal on glucose and lipid metabolism in pregnant women with GDM and 2) determine the feasibility of low-resistance and aerobic activity and measuring exercise metrics during pregnancy. The overarching objective of this study is to determine the effects of low-resistance and aerobic exercise on glucose and lipids following a meal in pregnant women with GDM. Women will perform either low-resistance or aerobic exercise. Blood will be taken before and 2 hours after a fixed meal. For safety, women will have supervised exercise and oxygen consumption will be measured throughout the activity.
PROBLEM TO BE SOLVED: To obtain a compsn. less irritating and excellent in conditioning effect and feeling on use by comprising one or more component selected from the group consisting of basic amino acid derivs. and their salts and, as an effective component, one or more members selected from the group consisting of higher alcohols. SOLUTION: This is a compsn. comprising 0.01-10 wt.% of one or more members selected from the group consisting of basic amino acid derivs. having formula I obtd. by addn. of an epoxyalkane to an amino acid such as arginine and their salts (A), and 0.1-30 wt.% of one or more members selected from the group consisting of higher alcohols such as stearyl alcohol (B) at B/A=10/100-100/0.5, and also <=50 wt.% of a nonionic surfactant such as a polyoxyethyleneglycol fatty acid ester, and the like. In the formula, R<1> and R<2> are each 8-22 C alkyl or alkenyl; X is a group represented by formula II; k is 0-5, where Y is a group represented by formula III when K=0, and an amino group when K=1-5; z is a group represented by formula IV; and m is 1-5.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and represents the main cause of liver cirrhosis and hepatocellular carcinoma. Cav3.2 is a T-type calcium channel that is widely present in tissues throughout the body and plays a vital role in energy and metabolic balance. However, the effects of Cav3.2 on the NFALD remain unclear. Here, we investigated the role of Cav3.2 channel in the development and progression of NAFLD. After 16 weeks on a high-fat diets (HFD), Cav3.2 knockout (Cav3.2 KO) improved hepatic steatosis, liver injury and metabolic syndrome in an NAFLD mouse model. We provided evidence that Cav3.2 KO inhibited HFD-induced hepatic oxidative stress, inflammation and hepatocyte apoptosis. In addition, Cav3.2 KO also attenuated hepatic lipid accumulation, oxidative stress, inflammation and hepatocyte apoptosis in palmitic acid/oleic acid (PAOA)-treated primary hepatocytes. These results suggest that therapeutic approaches targeting Cav3.2 provide effective approaches for treating NAFLD.
The mission of the SARP is to improve the understanding of severe asthma to develop better treatments. The SARP will gain a better understanding of asthma and its endotypes, in children and adults, by defining the disease at the molecular and cellular levels in the context of the temporal phenotypic expression of the disease. To this end, the SARP investigators will utilize both mechanistic and evoked phenotype approaches to: 1) characterize developmental molecular, cellular and physiologic phenotypes in children and adults with mild to severe asthma, and 2) to further elucidate the evolving pathobiology and pathogenesis of severe asthma and its sub-phenotypes and 3) compare these features over time. This approach involves a shared longitudinal protocol conducted across all participating centers which includes common information on all SARP participants. Additionally, the SARP investigators have each identified mechanistic research questions to be included in the shared longitudinal protocol. Together, these longitudinal and mechanistic approaches will enable prediction of phenotype stability/fluctuation and pharmacologic responses and identification of novel, disease-modifying targets for treatment.
The Secret Agent Society (SAS) Program is an intervention which involves subjects participating in 9 weekly two-hour therapy groups ('Club meetings') with 3 to 6 other children. The SAS intervention includes a number of components to help children apply the skills that they learn in the session to home. Parents will attend weekly parent support training sessions. 3 and 6 month booster sessions are conducted with both parents and children to help families with maintaining the skills that they have learned and to problem-solve new challenges that arise. Parent and child assessments will be completed at pre and post treatment (Wk 1 and Wk 10) and at 3-month and 6-month follow-up booster visits, for both parent and child participants.
Anatomic and functional preservation of the recurrent laryngeal nerve is a key element of thyroid surgery. Surgical exposure and visual identification of the nerve during thyroid surgery has been shown to provide the best rates of normal postoperative vocal fold function. Nevertheless, identification of the nerve sometimes can be difficult in patients who are heavily scarred or who have undergone previous surgery. Moreover, an anatomical intact nerve does not always correlate with normal vocal fold function. So it is mandatory to identify the nerve and to establish its function. Two techniques are described to facilitate identification of the nerve and to test its function. One is the neurostimulation with laryngeal palpation which is an intermittent monitoring techniques that permits to evaluate the contraction of cricoarytenoid muscle (laryngeal twitch ) after stimulation of RLN or vagal nerve with an electric stimulator probe. More recently some authors have suggested a continuous intraoperative neuromonitoring which provide audio and visual feed back when the nerve is electrically or mechanically stimulated during thyroidectomy. However controversy remains as to whether intraoperative neuromonitoring confers any significant benefit in injury prevention of recurrent laryngeal nerve.
Disclosed herein include systems, devices, and methods for counterfactual optimization. In some embodiments, spatial omics training data can comprise a plurality of training images each comprising a plurality of molecule channels. A training image label can be generated for each of a plurality of training images indicating presence of at least one T cell in the training image. A plurality of masked training images can be generated from a plurality of training images with any T cell present in a training image of the plurality of training images masked in a masked training image of the plurality of masked training images generated. A model comprising a classifier with the plurality of masked training images as input and the training image label as output can be generated. A counterfactual optimization can be performed to determine a tumor perturbation using a second plurality of images with no T cell present in each of the plurality of images.
<P>PROBLEM TO BE SOLVED: To provide a solubilized collagen fiber capable of rapidly and simply preparing itself to be formed into a collagen cosmetic in an aqueous solution state, by utilizing a cosmetic lotion, etc., and to provide the collagen cosmetic of a type of being prepared just before use.  <P>SOLUTION: This solubilized collagen fiber has an isoionic point of not more than a pH of 5 and an average fineness of not more than 10 dtex. The collagen cosmetic is prepared by dissolving the fiber in an aqueous liquid having a pH of 5.5 to 9.0. The solubilized collagen fiber is obtained by preparing solubilized collagen having an isoionic point of not more than a pH of 5, then preparing an aqueous solubilized collagen solution having a pH higher than the isoionic point of the solubilized collagen, and further spinning and drawing the solubilized collagen fiber by using the solution. An apparatus (1) which has spinning means (3, 5, 7, 9) for spinning the solubilized collagen fiber by extruding the aqueous solubilized collagen solution (A) into an organic solvent (S1) in a fibrous form, drawing means (11) for drawing the solubilized collagen fiber, and a solvent tank (13) for receiving a hydrophilic organic solvent (S2) used for soaking the drawn solubilized collagen fiber therein is used for producing the fiber.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This is a single center, open-labeled , single arm, prospective study which includes a safety run-in phase. The primary endpoint is the overall response rate which includes complete response (CR) and partial response (PR) at Week 12 and Week 24. The secondary endpoints include progression-free survival (PFS), overall survival (OS), and adverse events. There are two phases of the study. The first phase is the 'safety run-in phase'which plans to enroll 6 patients who would be observed for safety issues for 12 weeks after study drug administration. If no Grade ≥ 4 (CTCAE) adverse events (AE) occurs during this phase, the study would enter the second phase; if Grade ≥ 4 (CTCAE) AE happens during this phase, the study would be terminated. In the second phase of the study, another 24 patients would be enrolled. All enrolled patients would receive the study drug until progression of disease, intolerability of the drugs or Week 96 and would be followed every 4 weeks in the first 12 weeks, every 12 weeks until Week 48 and every 24 weeks until Week 96. The follow-up phase to assess PFS and OS will last from initiation of study drug to 36 months after enrollment (evaluation would be carried out every 24 weeks after Week 96). The total study duration will be 4 years after the last patient starts study medication.
The Inadequate Milk Perception Scale was administered to the mothers to determine the mothers who thought that their milk was inadequate by face-to-face interview method before discharge from the hospital after delivery. Mothers with low scale scores were randomly assigned to the control group as described in the intervention group. Then, Personal Information Form-1, Tendency to Discontinue Breastfeeding Scale and Breastfeeding Self-Efficacy Scale were applied to the mothers. The mothers determined as the control group were called by the investigators via telehealth application between the 2nd-5th days, 13th-17th days, 38th-40th days, 2nd-3rd months, 4th-5th months and at the end of the 6th month and the relevant forms were applied again. No intervention was made to the mothers in the control group.
The investigators will study up to one thousand subjects who will be randomized into same-gendered teams of three or volunteer as acquainted groups of three . Teams will be randomized to receive oxytocin or placebo. The investigators will first measure baseline personality traits including prosocial orientation. Cohesion will then be measured using a cooperative, virtual unmanned aerial vehicle (UAV) flying mission. All online behavior will be recorded within the task and all offline, real world, behavior will be video recorded throughout the study by digital cameras for later behavioral coding. To measure biobehavioral synchrony, autonomic physiology will be recorded and saliva samples will be taken throughout behavioral testing.
After gingival healing the newest low-profile OT Equators® (Rhein83) will be screwed on to the implants, using the OT Equator® square screwdriver (Rhein83), with a torque range of 22-25 N cm. The cuff heights ranged from 0.5 to 7.0 mm, depending on the height of the transition zone of each implant, easily measured using the color-coded millimeter Cuff Height Measurer Gauge (Rhein83) after healing abutment removal.
Patients will receive spinal anesthesia with 0.5% bupivacaine 9 mg + fentanyl 10 mcg. Following the completion of surgery, ultrasound-guided bilateral transversus abdominis plane block will be done with 0.375% ropivacaine 15 ml per each side.
BACKGROUND: Minimally invasive distal pancreatectomy has become a widely accepted procedure for tumors located in the pancreatic body or tail. However, pancreatic transection by linear stapler is generally avoided for pancreatic body tumors located above the portal vein because the surgical margin width is narrowed after taking into account the cutting allowance for insertion of the stapling device. Herein, we report a parenchymal clamp-crushing procedure that provides a sufficient surgical margin in pancreatic transection.
METHODS: Two patients with suspected early pancreatic cancer underwent pancreatic transection using the clamp-crushing procedure. The planned pancreatic transection line was set just to the left of the gastroduodenal artery in both cases. Robotic and laparoscopic distal pancreatectomy were performed in 1 patient each. Patients were positioned supine with split legs. Parenchymal transection was performed with crushing by VIO 3 (ERBE Elektromedizin) operated in softCOAG Bipolar mode with Effect 2/modulation 50. After crushing, remnant tissue was cut in autoCUT Bipolar mode operated by VIO 3 with Effect 2/modulation 50, or cut after secured by clipping.
RESULTS: The surgical duration was 253 and 212 minutes, and estimated blood loss was 0 and 50 mL in the 2 patients, and both were discharged with uneventful courses. Pathologic examination confirmed a negative surgical margin in both patients.
CONCLUSION: Clamp-crushing pancreatic transection for distal pancreatectomy might be a suitable treatment option for achieving sufficient surgical margin in pancreatic body tumors located close to the portal vein.
The invention discloses a traditional Chinese medicine combination for treating qi and blood deficiency type burns. The traditional Chinese medicine combination for treating qi and blood deficiency type burns is characterized in that the traditional Chinese medicine combination is prepared by using the following medicinal materials in parts by weight: 9-21 parts of Acanthopanax brachypus Harms, 20-40 parts of Rhizome of Perny false Fairybells, 4-16 parts of Stemmacantha carthamoides, 9-21 parts of heterophylly falsestarwort root, 9-21 parts of Gomphocarpus fruticosus, 4-16 parts of Cicerbita cyanea (D. Don) Beauv, 10-30 parts of Pilea notata C. H. Wright, 3-15 parts of Fructus terminaliae Billericae, 4-16 parts of Rhodomyrtus tomentosa, 10-30 parts of Lysimachia barystachys Bge, 6-15 parts of Holostemma ada-kodien J. A. Schultes, 10-30 parts of Asplenium varians Wall, 6-18 parts of Mecodium badium (Hook. et Grev.) Cop., 9-21 parts of Metaplexisjaponica and 4-16 parts of Circaea cordata Royle. The traditional Chinese medicine combination is used for treating qi and blood deficiency type burns, the curative effect is good and the effective rate is high.
BACKGROUND/OBJECTIVES: No simple, accurate diagnostic tests exist for exocrine pancreatic insufficiency (EPI), and EPI remains underdiagnosed in chronic pancreatitis (CP). We sought to develop a digital screening tool to assist clinicians to predict EPI in patients with definite CP.
METHODS: This was a retrospective case-control study of patients with definite CP with/without EPI. Overall, 49 candidate predictor variables were utilized to train a Classification and Regression Tree (CART) model to rank all predictors and select a parsimonious set of predictors for EPI status. Five-fold cross-validation was used to assess generalizability, and the full CART model was compared with 4 additional predictive models. EPI misclassification rate (mRate) served as primary endpoint metric.
RESULTS: 274 patients with definite CP from 6 pancreatitis centers across the United States were included, of which 58 % had EPI based on predetermined criteria. The optimal CART decision tree included 10 variables. The mRate without/with 5-fold cross-validation of the CART was 0.153 (training error) and 0.314 (prediction error), and the area under the receiver operating characteristic curve was 0.889 and 0.682, respectively. Sensitivity and specificity without/with 5-fold cross-validation was 0.888/0.789 and 0.794/0.535, respectively. A trained second CART without pancreas imaging variables (n = 6), yielded 8 variables. Training error/prediction error was 0.190/0.351; sensitivity was 0.869/0.650, and specificity was 0.728/0.649, each without/with 5-fold cross-validation.
CONCLUSION: We developed two CART models that were integrated into one digital screening tool to assess for EPI in patients with definite CP and with two to six input variables needed for predicting EPI status.
A computer implemented method and a system choosing optimal disease treatment among several possible treatment options for a patient are provided. The system computes cancer-free survival rates for each considered treatment based on predicting recurrence rate of a disease and/or cancer outcome for a particular patient. The treatment survival models use quantitative data from histopathological images of the patient, clinical data and other patient information. The system segments the histopathological images into biologically meaningful components; automatically determines disease-affected regions in one or more of the segmented image components. The system also partitions the disease-affected regions in each image into a number clusters. Those that are determined to be the most associated with the disease outcome are used as a source of the imaging information for the survival modeling. Optimal treatment is suggested as the treatment with probability of the cancer free survival within a certain time period is maximized.
The invention discloses a medicinal globefish oil making method. The existential state of tetrodotoxin in vivo is not affected, and the curative effect of the tetrodotoxin can be improved. The technological difficulty of high-purity tetrodotoxin extraction is high, and technology and equipment are complex. However, according to the medicinal globefish oil preparation method, tetrodotoxin extraction and tetrodotoxin removing are not needed, the general equipment and technology for making oleum morrhuae are adopted, the technology is simple, the cost is low, and curative tetrodotoxin popularization is facilitated; the utilization value of globefish viscera is improved, the whole liver and ovary (comprising eggs) are utilized instead of utilizing only toxin in the viscera, other abundant nutrition ingredients in the whole liver and ovary are sufficiently utilized, the rich highly unsaturated fatty acids can enhance the comprehensive treatment effect and enhance the immunologic function and also has the tumor suppression effect, and the suppression rate of globefish oil to tumors can reach 59%. The globefish oil can be developed as a health care product for tumor suppression, immunity increasing and addiction removing besides detoxification, analgesia and anesthesia. Globefish breeding has no value in the tetrodotoxin related industries originally, however, by means of the medicinal globefish oil making method, bred globefish becomes indispensable raw materials, and the values besides the edible value of globefish are improved.
This study aimed to evaluate the presence of dynamic hyperinflation (DH) during the Glittre-ADL test (TGlittre) coupled to the dynamic ventilation measurements in people with central obesity (pwCO) and to correlate it with lung mechanics at rest. Sixty-four pwCO underwent TGlittre and the following resting lung function tests: spirometry and impulse oscillometry system (IOS). On TGlittre, 22 participants presented DH at the end of the test (DH group), while 42 did not present DH (NDH group). Body mass index (BMI), waist circumference (WC), and hip circumference (HC) were higher in the DH group than in the NDH group. IOS abnormalities were more common in the DH group compared to the NDH group. TGlittre time significantly correlated with BMI, WC, waist-to-hip ratio (WHR), and neck circumference (NC). Delta inspiratory capacity correlated significantly with WC, HC, NC, and resonance frequency measured by IOS. Thus, pwCO perform worse on TGlittre, and DH is frequent in those with higher anthropometric indices and worse lung mechanics.
The optimal surgical procedure for each patient depends on the characteristics of the tumor. Patients were placed in French position and a laparoscopic-assisted partial hepatectomy was performed under CO2 pneumoperitoneum pressure 12-14 mmHg (1 mmHg =0.133 kPa). In most cases, a 4-well or 5-well method was used under general anesthesia.