anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A cosmetic agent for the treatment of keratinic fibres, in particular human hair, which comprises a powder containing hydrophobically modified silicon dioxide and particles comprising a silicone elastomer. Preferably, the particles comprising a silicone elastomer are a composite material comprising a cross-linked a polyorganosiloxane and silicon dioxide, preferably a silica silylate. The particles may have an average particle size of from 0.1 to 20µm. Preferably, the hydrophobically modified silicone dioxide is a silylation product of a reaction of a precipitated silica and/or a fumed silica with an organosilicon compound such as an alkylsiloxane such as trimethysilane or hexamethyldisilazane. The cosmetic agent may comprise from 50 to 90%wt water, 5 to 30%wt of the hydrophobically modified silicon dioxide; and from 2 to 30%wt particles comprising the silicone elastomer. The cosmetic agent may be provided in a spray applicator.
This study aims to develop NICE Support program, and examine the effects of an NICE program in heart failure patients. An experimental design is used. Subjects are selected using a purposeful sampling and are randomly assigned to the intervention or control group by using block size randomization method. Patients in the intervention group will receive a 12 week NICE Support program including: individual consultation, nutritional consultation, teaching exercise which contain walking and resistance exercise by using elastic bands and elastic balls. Data are collected by physical indicators and a structural questionnaire to measure frailty, quality of life, social support, anxiety and depression, symptom distress at baseline, 4 weeks, 12 weeks and 24 weeks . Data analysis includes descriptive statistics, Pearson correlation coefficient, independent t test, chi square, one way ANOVA and generalized estimating equation.
The study "Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumoniae: stability, compatibility, population pharmacokinetic studies and breakpoint selection, R. De Jongh, et al, 2007 ", the author states that no adverse effects were found following injection of Temocillin. In the study "Temocillin use in England: clinical and microbiological efficacies in infections caused by extentedspectrum and / or derepressed AmpC β-lactamase-producing Enterobacteriaceae, I. Balakrishnan, et al, 2011, the author faced two cases of Clostridium difficile with a positive toxin test. The first patient received three doses of Amoxicillin / clavulanic acid followed by one week's treatment with Temocillin. This one has developed Clostridium difficile diarrhea on the last day of antibiotic treatment. The second patient did not not received Temocillin in the 6 weeks prior to diarrhea but received 8 days of Meropenem just before this diarrhea. In all cases, Temocillin can not be clearly attributed to this adverse effect and no patient developed pseudomembranous colitis.
This invention describes novel methods for fabricating nano/micro particles and capsules through template decomposition which incorporates the to-be-encapsulated molecules which are precipitated in pores of particles or in solution, i.e. below their isoelectric point, drying or by solvent adjustment methods. The encapsulation process can be followed by a deposition or adsorption of a protective shell that regulates release of the encapsulated material. The encapsulation, inclusion, manipulation, and release of various materials and bio-materials is to be conducted by delivery vehicles which are particles and capsules with sizes in the range of nanometers and micrometers. They can possess multicompartment and anisotropic geometries and can carry one or several types of various molecules. This invention can potentially be used for controlled delivery, manipulation, and release in a variety of applications requiring delivery vehicles such as cell cultures, in-vivo, subcutaneous incorporation, injection, spray-inhalation and planar surfaces, films, and stents.
Blood urea nitrogen (BUN) level is one of the commonly used indicators to assess renal function and systemic immune-inflammatory status. In the adolescent population, changes in BUN levels may be associated with a variety of factors, including physiologic dehydration, lifestyle influences such as nutritional intake, physical activity, and possible endocrine or metabolic disorders. In recent years, more and more studies have shown that BUN levels are not only a reflection of kidney function, but it may also be related to the inflammatory state of the body. The Systemic Immune Inflammatory Index (SII) is a comprehensive index that takes into account platelet counts, neutrophil and lymphocyte counts, and is thought to be effective in reflecting the body's immune status and inflammatory response. However, research on the relationship between the two, SII and BUN, remains understudied in the adolescent population. The purpose of this study was to examine the relationship between SII and BUN levels in a population of American adolescents and to further analyze the factors that influence it. We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) database. Using descriptive statistics, correlation analysis, and regression analysis, we explored the relationship between SII and BUN levels. We found a significant negative correlation between SII and BUN levels, with BUN levels decreasing when SII levels increased (BUN as the dependent variable and SII as the outcome variable). We performed a multiple regression analysis of this relationship, controlling for possible confounders such as gender, age, race, and BMI, and found that this negative correlation remained significant. Our findings reveal an important relationship between SII and BUN levels and provide new perspectives for understanding adolescent health.
Acute kidney injury (AKI) is a significant issue in public health, displaying a high occurrence rate and mortality rate. Ferroptosis, a form of programmed cell death (PCD), is characterized by iron accumulation and intensified lipid peroxidation. Recent studies have demonstrated the pivotal significance of ferroptosis in AKI caused by diverse stimuli, including ischemia-reperfusion injury (IRI), sepsis and toxins. Autophagy, a multistep process that targets damaged organelles and macromolecules for degradation and recycling, also plays an essential role in AKI. Previous research has demonstrated that autophagy deletion in proximal tubules could aggravate tubular injury and renal function loss, indicating the protective function of autophagy in AKI. Consequently, finding ways to stimulate autophagy has become a crucial therapeutic strategy. The recent discovery of the role of selective autophagy in influencing ferroptosis has identified new therapeutic targets for AKI and has highlighted the importance of understanding the cross-talk between autophagy and ferroptosis. This study aims to provide an overview of the signaling pathways involved in ferroptosis and autophagy, focusing on the mechanisms and functions of selective autophagy and autophagy-dependent ferroptosis. We hope to establish a foundation for future investigations into the interaction between autophagy and ferroptosis in AKI as well as other diseases.
OBJECTIVES: Alzheimer's disease (AD) presents a major global health issue of significant socio-economic impact. Pharmacological treatments for AD have limited efficacy, prompting the exploration of alternative therapies, such as repetitive transcranial magnetic stimulation (rTMS), a promising non-invasive technique to enhance cognitive function in AD patients. Our systematic review and meta-analysis aim to evaluate the efficacy of rTMS in relation to cognitive function in AD patients, identify optimal rTMS stimulation parameters, and understand the underlying neural mechanisms.
METHODS: We conducted a comprehensive literature search in PubMed using predefined search terms to identify original research articles investigating the effects of rTMS on cognitive function in AD patients. We selected only randomized controlled trials (RCTs) with sufficient quantitative data for comparing active rTMS to the sham-coil treatment, and then performed a random effects meta-analysis using standardized mean differences (SMDs) to synthesize the effects across studies.
RESULTS: The systematic review included 22 studies, among which 14 RCTs met our criteria for meta-analysis. High-frequency rTMS, particularly targeting the dorsolateral prefrontal cortex (DLPFC), evoked significant cognitive improvements in AD patients, with a moderate positive effect size of rTMS on cognitive function (Hedges' g=0.580, 95% CI [0.268, 0.892], p<0.001), albeit with substantial heterogeneity (I²=59%). Funnel plot asymmetry and Egger's test suggested a potential publication bias, but fail-safe N analysis indicated a robust finding. Moreover, anhedonia-apathy symptoms and motor-cognitive exercises mediated the efficacy of tTMS in ameliorating cognitive functioning across several studies.
CONCLUSION: rTMS demonstrates moderate efficacy in improving cognitive function in AD-patients, most distinctly with high-frequency rTMS stimulation protocols targeting the DLPFC area. The meta-analysis support rTMS as a viable therapeutic intervention for cognitive enhancement in AD. Future promising research should focus on personalized treatment strategies targeting mediating factors, baseline connectivity patterns, and TMS-induced neuroplasticity in AD.
The PROFUTURE study: A prospective, multicenter, observational, case-control study with collection of peripheral blood and clinical data from clinical networks in order to develop machine learning models for discovering cancer from non-cancer. According to the statistical hypothesis based on expected detection performance, the study will enroll approximately 3,830 participants, including 2,138 participants with cancer (case arm) and approximately 1,692 representative participants without a clinical diagnosis of cancer after medical screening (control arm). Participants pre-matched by age and gender will be divided into training set and validation set in a ratio of approximately 7:3. The validation set will be blinded until the models are developed. Clinical information, demographics, and medical data relevant to cancer status are collected from all participants and their medical records at baseline. The participants of control arm will be asked to report suspected cancer diagnosis status within 6 months after blood collection.
A system for implanting surgical material in a patient's body is disclosed. The system comprises a two-dimensional (2D) laser cutter network comprising a 2D laser cutter and a processor. The processor is configured to perform the steps of capturing an image of an open area of a patient's body and processing a drug implant substrate to create a customized drug implant substrate. The customized drug implant may be created based on the captured image to correspond with the open area of the patient's body. The drug implant substrate is shaped using the 2D laser cutter. The processor is further configured to perform the steps of placing the customized drug implant substrate in the open area of the patient's body and sealing the open area after placing the customized drug implant substrate in the open area.
Data-based decision-making (DBDM) using curriculum-based measurement (CBM) data has demonstrated effectiveness in improving academic achievement for students with or at risk for learning disability. Despite substantial evidence supporting DBDM, its use is not common practice for many educators, even those who regularly collect CBM data. One explanation for its lack of widespread use is that educators may not receive adequate training in the DBDM aspects of CBM. Espin et al. examined the extent to which DBDM is represented in CBM professional development (PD) materials and found that the topic was significantly underrepresented (12% to 14% of CBM PD material content) compared with other CBM topics. The purpose of this study was to conduct a conceptual replication of the Espin et al. systematic review through an analysis of CBM content in practitioner journal articles. The present review includes 29 practitioner articles coded to the four CBM categories used in the Espin et al. study: (a) general CBM information, (b) conducting CBM, (c) data-based decision-making, and (d) other. Results revealed a pattern similar to the one found by Espin et al. with approximately 18% of the content of practitioner articles on CBM devoted to the topic of decision-making. These findings strengthen the recommendation from Espin et al. for increased attention to DBDM in CBM training materials.
Recently has been using the LED, known by its acronym in English LED (Light Emitting Diode), devices that are light-emitting non-coherent and monochromatic, having a longer wavelength (± 10 - 30 nm) compared to lasers. The difference between the fundamental radiation emitted by a laser and an LED is the coherence of the beam.
PURPOSE:To obtain W/O/W-type composite emulsion having high stability by preparing a mixture system of an oil phase containing nonion surfactant and a water phase containing hydroxypropyl cellulose, and emulsifying this mixture near the temp. at which hydroxypropyl cellulose does not melt. CONSTITUTION:Hydroxypropyl cellulose(HPC) is used as a hydrophilic emulsifier. As for a lipophilic emulsifier, noion surfactant such as sorbitane ester is used. When the mixture of an oil phase and an water phase containing these emulsifiers is emulsified near the temp. for stable HPC, adsorption on the interfaces of HPC is promoted and the system is stabilized. Further, the system is processed at >=0.05ml sec shear rate to obtain a fine emulsion. Thereby, the obtd. emulsion has high productivity and stability.
Patient will be approached upon admission to labor and delivery floor (Standard of care). The study will be presented to the patient and if they agree, they will be consented. (Study). Upon epidural patient request patient will be randomized to A-US vs B-US based on the randomization table. Ten envelopes will be available with the randomization choice. (Study). The resident will walk in with both US devices into the room (for patient blinding) and perform scan with the device the randomization table called for. (Study). After performing scan and markings of the patients back, the research fellow or clinical fellow will be called into the room to evaluate the number of needle manipulation and provide surveys related to patient and labor analgesia satisfaction. (Study).

Number of needle insertion attempts: defined as advancement of the needle through the skin in an effort to enter the epidural space; a needle requiring withdrawal from the skin for reinsertion is to be counted as an additional insertion attempt. Time to landmark identification: defined as the time interval between the start of needle puncture site identification and the time to first needle puncture attempt. The start time of needle puncture site identification in both the LT and UST corresponds to when the resident physician first places his/her hand on the patient to palpate the back. In both groups, all materials, supplies, and equipment will be prepared and readily available prior to the start of the procedure.
PROBLEM TO BE SOLVED: To maintain performance by making the innermost layer of a plurality of layers forming a packed body using an ethylene-(meth)acrylic acid copolymer to stabilize the content of nitroglycerin of a plaster agent. SOLUTION: A packed body of a nitroglycerin plaster agent 1 is made up of a PET layer as the outermost layer, the subsequent PE layer 3 and an aluminum foil layer 4 thereinside and the innermost layer 5 is made of an ethylene-(meth) acrylic acid copolymer. The innermost layer 5 is made of an ethylene-(meth)acrylic acid copolymer. The ethylene-(meth) acrylic acid copolymer has preferably the content of about 5-20-wt.% of (meth)acrylic acid. When the content is under the value, the barrier performance is lowered and when the content exceeds the value, the polarity becomes too high to make the nitroglycerin easily transfer. So, the content is more preferably about 6-15wt.%. The number of layers is preferably 2-5. The thickness of the innermost layer 5 is preferably about 5-50μm.
PURPOSE: An anticancer therapeutic agent containing Salmonella which expresses TNF-alpha is provided to enhance anticancer effects of chemotherapeutic agent, radiation therapy, or immunocyte therapeutic agent with minimized side effects. CONSTITUTION: An anticancer therapeutic agent contains Salmonella which expresses TNF-alpha. The anticancer therapeutic agent is used together with anticancer agents. The anticancer agent is cisplatin, doxorubicin, or etoposide. The cancer is testicular cancer, ovarian cancer, lung cancer, bladder cancer, gastric cancer, cervical cancer, or breast cancer. The anticancer therapeutic aid is used together with an immunocyte therapeutic agent using dendritic cells or lymphocytes.
PURPOSE: To obtain a skin external agent containing a water-soluble rutin and a tyrosinase-activity inhibitor as active components, having excellent beautifying effect, accordingly effective for prevention, improvement, etc., of darkening of skin, spots and freckles caused by sunburn, etc., and excellent in stability and safety. CONSTITUTION: This external agent contains (A) a water-soluble rutin [preferably, α-glycosylrutin of the formula (R is glucose, mannose, etc.); the content of rutin is 10-85wt.%] and (B) a tyrosinase-activity inhibitor [e.g. cysteine, an extract of SOUHAKUHI (bark of Morus bombycis) or an extract of TOUKI (root of Angelica acutiloba)] as active components. The content of the component A is preferably 0.00001-5wt.% in terms of rutin. That of the component B is preferably 0.001-5% in term of dried solid. Further, α-glycosylrutin of the formula is obtained e.g. by mixing rutin with starchiness such as dextrin followed by an enzymatic reaction.
The invention relates to a hydrophobic polymer dispersion and a solvent-free process for the preparation thereof. According to the invention, the dispersion contains starch ester together with dispersion admixtures known as such. According to the process, the polymer is first mixed with a plasticizer in order to obtain a plasticized polymer blend. The plasticized polymer blend is then mixed with dispersion admixtures and water at an elevated temperature so as to form a dispersion. The plasticizing of the polymer and the dispersion of the mixture in water can be performed in an extruder. The obtained dispersion is homogenized in order to improve its stability. The dispersion obtained by the invention can be used to coat paper or board, as a primer or a component in paint or labelling adhesives, and it is also suitable for the production of cast films and as a binder in materials based on cellulose fibres, as well as for coating medicinal preparations.
When allocated in the control group, the intensity of the initial thirst was measured by Visual Numerical Scale (VNS), which ranged from 0 (no thirst) to 10 (very intense thirst) and the discomfort of the initial thirst was measured through the Perioperative Thirst Discomfort Scale (PTDS), which is composed of 7 attributes and ranges from 0 to 14. After maintaining the usual care, that is, reaffirming the need for absolute fasting of food and drinks for 20 minutes, the final intensity and discomfort were measured using the same scales.
Parents in the control group will via a web-based portal be able to view four pre-recorded lectures during four weeks. The lectures will be around 10 minutes long and have a content similar to the group meetings that are offered to the intervention group but more superficial and without printed material and reflection practices.
Described are generally a T-cell immune response cDNA 7 (TIRC7) encoding a T-cell transmembrane protein as well as peptides and polypeptides derived therefrom and antibodies recognizing said (poly)peptides. More particularly, peptide and polypeptide as well as antibodies being capable of inhibiting T-cell stimulation through the T-cell membrane protein (TIRC7) are provided. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins, peptides or polypeptides are described. Additionally, pharmaceutical and diagnostic compositions are provided comprising any one of the afore-described polynucleotide, vector, protein, peptide, polypeptide, or antibody. Furthermore, methods and uses for modulating immune responses through the TIRC7 membrane protein as well as pharmaceutical compositions comprising agents which act on the TIRC7 membrane protein or its ligand are described. Also, the use of said polynucleotide, vector, protein, peptide, polypeptide, or antibody for the preparation of pharmaceutical compositions for use in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided. Furthermore, methods for modulating (antigen-specific) T-cell unresponsiveness inducing maintaining or reversing T-cell unresponsiveness by inhibiting or stimulating an (unresponsive) T-cell through the TIRC7 membrane protein are encompassed herein.
PURPOSE: The aim of this study was to explore relations between speech sound disorder severity and selective mutism in a group of children with 7q11.23 duplication syndrome (Dup7), a genetic condition predisposing children to childhood apraxia of speech (CAS) and other speech sound disorders and to anxiety disorders, including selective mutism and social anxiety disorder.
METHOD: Forty-nine children aged 4-17 years with genetically confirmed Dup7 completed the Goldman-Fristoe Test of Articulation-Second Edition (GFTA-2), the Expressive Vocabulary Test-Second Edition (EVT-2), and the Differential Ability Scales-Second Edition (DAS-II). Parents completed the Anxiety Disorders Interview Schedule-Parent (ADIS-P).
RESULTS: Mean standard scores (SSs) were 65.67 for the GFTA-2, 92.73 for the EVT-2, and 82.69 for the DAS-II General Conceptual Ability (GCA; similar to IQ). Standard deviations for all measures were larger than for the general population. GFTA-2 SS was significantly correlated with both EVT-2 SS and DAS-II GCA. Based on the ADIS-P, 22 participants (45%) were diagnosed with selective mutism and 29 (59%) were diagnosed with social anxiety disorder. No significant differences in performance on any of the measures were found either between the group with a selective mutism diagnosis and the group that did not have selective mutism or between the group with a selective mutism and/or social anxiety disorder diagnosis and the group that did not have either disorder.
CONCLUSIONS: For children with Dup7, neither the diagnosis of selective mutism nor the diagnosis of selective mutism and/or social anxiety disorder was related to severity of speech sound disorder, expressive vocabulary ability, or overall intellectual ability. Accordingly, treatment for speech sound disorder alone is unlikely to lead to remission of selective mutism or social anxiety disorder. Instead, selective mutism and/or social anxiety disorder should be treated directly. Further research is needed to determine if these findings generalize to other populations, such as children with idiopathic CAS.