anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
IMPORTANCE: There is limited literature or even consensus on the suture material used for posterior vaginal repairs.
OBJECTIVES: This study aimed to compare outcomes of barbed versus nonbarbed delayed absorbable suture used for posterior colporrhaphy.
STUDY DESIGN: This study conducted a randomized controlled trial of 72 women undergoing posterior repair using standardized technique-concurrent procedures permitted with barbed (n = 36) or nonbarbed (n = 36) suture. Standardized examinations, validated questionnaires, and a visual analog scale (VAS) were completed at baseline, 6 weeks, and 12 months, and a telephone interview was conducted at 6 months. The primary outcome was posterior compartment pain at 6 weeks, measured by a VAS.
RESULTS: Seventy-two women enrolled, with follow-up rates 6 weeks (100%), 6 months (90.3%), and 12 months (73.6%). Demographics were similar between groups. A VAS with movement was not different between groups at 6 weeks. The odds of experiencing vaginal pain, having myofascial pain on examination, or being sexually active postoperatively were not different between the groups. There were no differences in the length of posterior colporrhaphy, surgical times, or hospital length of stay between the groups. Suture passes were lower in the nonbarbed group (median, 4 vs 7; P = <0.001), and suture burden was higher in the nonbarbed group (median, 26.9 vs 10.5 cm; P = <0.001). There was overall improvement in Pelvic Floor Distress Inventory Short Form 20 prolapse and colorectal subscores but no differences between groups. Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire Short Form 12 scores improved, and dyspareunia decreased at 6 and 12 months in both groups. In addition, there were few anatomic recurrences at 6 weeks (0%) and 12 months (3.4%) and few adverse events.
CONCLUSIONS: This study found no differences in primary or secondary outcomes; however, both suture types resulted in clinical improvements in quality-of-life measures and sexual function.
A pet chew with a dental health function includes a carrier and plural dental health members disposed on the surface of interior of the carrier. The dental health members include probiotic, prebiotic and adhesive. The probiotic is a human intestinal probiotic group, and a human beneficial probiotic. Since pets like molar, the chew induces a pet to chew for more than 3 minutes, and the probiotic and prebiotic can clean the pet's teeth during the long chewing time. An adhesive is mixed into the probiotic and prebiotic, so that a large amount of probiotic and prebiotic is adhered into the pet's mouth. The prebiotic promotes the colonization of the probiotic, forms advantageous probiotic groups, and inhibits the breeding of germs in the pet's mouth, and the growth of human harmful germs, so as to achieve the effects of maintaining the pet's oral health and eliminating bad breath.
The invention discloses the Newcastle disease poison strain of a strain separation, its whole genome sequence and application thereof, belong to separation and the Application Areas of Newcastle disease poison strain.First the present invention discloses the whole genome sequence of the Newcastle disease poison strain of separation, does is its nucleotides sequence classified as SEQ? ID? shown in NO.1.The invention also discloses a strain newcastle disease virus YT strain, does is its microbial preservation numbered: CGMCC? No.8789.Immunogenicity comparative result shows, and the YT strain that the present invention is separated has good immunogenicity, comparatively La can be provided? the better clinical protection rate of Sota vaccine and can effectively reduce toxin expelling rate.The blood clotting Inhibition test that intersects shows, is YT strain antiserum(antisera) of the present invention to YT antigen and La? Sota antigen all has good cross reactivity.Newcastle disease virus YT of the present invention strain and genome sequence thereof can be used in the neutralizing antibody preparing prevention newcastle disease virus vaccine and anti-newcastle disease virus.
The invention discloses a preparation method for a traditional Chinese medicine lotion for treating malnutritional pustule on sole and belongs to the technical field of traditional Chinese medicine preparation methods. The malnutritional pustule on sole is treated by adopting antibiotics and sulfonamides generally at present, but the antibiotics and the sulfonamides are big in toxic and side effects. The technical scheme disclosed by the invention is that the preparation method for the traditional Chinese medicine lotion for treating the malnutritional pustule on sole comprises the following steps of: putting cubilose, human milk, Fructus Ziziphi Jujubae, Chinese yam, triticum aestivum, radix pseudostellariae, black-bone chicken, cabbage, arillus longan, Rhizoma Atractylodis Macrocephalae, radix paeoniae alba, American ginseng, Angelica sinensis, semen nelumbinis, Codonopsis pilosula, fructus alpiniae oxyphyllae, Astragalus mongholicus, rhizoma polygonati, polished round-grained rice, rhizoma zingiberis, maltose, prepared rehmannia root, Polygonum multiflorum, Angelica sinensis, radix paeoniae alba, longan pulp, honey and liquorice in water and soaking; then, decocting on a slow fire; and filtering to remove dregs to obtain a decocted soup, i.e. the traditional Chinese medicine lotion for treating the malnutritional pustule on sole. The preparation method for the traditional Chinese medicine lotion for treating the malnutritional pustule on sole has the advantages that the traditional Chinese medicine lotion is simple in preparation, is small in toxic and side effects of the prepared traditional Chinese medicine lotion, is short in course of treatment and is high in recovery rate. The untoward effects generated by applying Western medicines can also be avoided.
A wasting station for receiving a wasted medication from a medication dispenser is provided. The wasting station includes a base and a locking mechanism. The base includes a weight sensor to measure a weight of a waste container supported by the base. The wasting station can determine, based on the measured weight, a volume of the wasted medication positioned within the waste container. The locking mechanism includes a first end coupled to the base. The locking mechanism also includes a second end coupled to the waste container when the locking mechanism is in a first position and decoupled from the waste container when the locking mechanism moves from the first position to a second position, thereby allowing for removal of the waste container.
Ninety male subjects will be equally allocated, according to their age, to either the younger NHE (Nordic Hamstring Exercise) group (aged between 18 and 22 years), the older NHE group (aged between 30 and 40 years) or the control group (aged between 18 and 40 years old). Potential candidates will be excluded from this study if they have a history of hamstring injuries, or a recent severe trauma or surgery in the lower extremity. All participants must perform at least 1 hour of weekly sport participation and do not participate in more than 3 training sessions a week. To ensure valid measurements of eccentric strength and muscle shear modulus, subjects will be instructed not to engage in strenuous training or sport activities 48 h prior to testing. All participants will be informed regarding the aim, content and possible risks associated with the experimental approach before they will be asked to sign an institutionally approved informed consent document, indicating voluntary participation in this study. Prior to the first training session, participants will undergo both a bilateral isokinetic eccentric and concentric strength protocol and an ultrasound elastographic assessment of the hamstring muscles to determine baseline strength (eccentric and concentric) and shear modulus of the posterior thigh muscles, respectively. Participants will be instructed not to engage in strenuous training or sport activities 48 h prior to testing to ensure a valid measure of the hamstring muscle-tendon elasticity. After completion of all the pre-training assessments, participants in the NHE groups will be familiarized with the correct execution-modalities of the eccentric hamstring exercise (NHE). For a period of 12 weeks, both experimental groups will perform a progressive eccentric strength training program targeting the hamstring muscles, solely consisting of the NHE. On the other hand, the control group will be instructed not to engage in any lower limb strength training. After completing the final training session, hamstring eccentric strength and shear modulus of all participants will be reassessed. The isokinetic strength protocol will be systematically conducted after all shear modulus measurements have been finished in order to avoid acute influences of previous exertion on the elasticity measurements.
Active LLTS will be performed by use of a neuromodulation device with electrodes attached to the tragus of the ear. Stimulator will be applied continuously for 1 hour daily for 12 weeks.
BACKGROUND: Exercise has shown positive effects on fatigue, exhaustion, neuropathy, and quality of life in cancer patients. While on-land exercises have been studied, the aquatic environment offers unique advantages. Water's density and viscosity provide resistance, enhancing muscle strength, while hydrostatic pressure improves venous return. This trial aims to investigate the effect of aquatic exercises on time to return to work, work hours, work-related difficulties, daily life activity and participation, quality of life, exhaustion, fatigue, and neuropathy among cancer patients, compared to on-land exercise intervention group and a non-exercise group.
METHODS: This randomized controlled trial will include 150 cancer patients aged 18-65 years with stage III colon cancer or breast cancer patients with lymph node involvement. Participants in the aquatic exercise intervention group will undergo an 8-week, twice-weekly group-based Ai-Chi program, while the on-land exercise group will perform identical exercise. The control group will not engage in any exercise. The primary outcome will be assessed using an employment barriers questionnaire, capturing return to work date and working hours and daily life participation and activity and quality of life. Secondary outcomes include exhaustion, fatigue, and neuropathy. Data will be collected at baseline, post-intervention (8 weeks), and at 3,12, and 24 months. Mixed variance analyses will explore relationships among groups and over time for independent variables, with separate analyses for each dependent variable.
DISCUSSION: The potential benefits include an earlier return to work for patients, reducing their need for social and economic support. The study's implications on socio-economic policies are noteworthy, as a successful intervention could offer a cost-effective and non-invasive solution, improving patients' quality of life and increasing their participation in daily activities. This, in turn, could lead to a faster return to work, contributing to both personal well-being and broader societal interests by reducing reliance on social services.
TRIAL REGISTRATION: The trial is registered at ClinicalTrials.gov NCT05427344 (22 June 2022).
From the fact that microorganisms are the most common factors causing pain, this study aimed to evaluate effect of 940 nm diode laser disinfection performed in addition to conventional irrigation on postoperative pain of retreatment cases. Eighty-four patients with chronic apical periodontitis were treated. Root canal fillings were removed using rotary files. Root canals were irrigated using sodium hypochlorite between instrument changes. Final irrigation was performed using sodium hypochlorite and ethylenediaminetetraacetic acid (EDTA). The cases were randomly allocated into 2 groups: Group 1: Diode laser disinfection group, Group 2: control group. Root canal fillings were applied and crowns were restored. All treatments were completed in a single appointment. Patients were given a pain scale and they were requested to mark the code that reflects their pain intensity during 3 days.
PURPOSE:To obtain an ibuprofen tablet having masked disagreeable taste without suppressing the development of initial effect of anti-inflammatory and analgesic action and producible without causing troubles in tableting, by placing excipient layers at the top and bottom of a layer containing ibuprofen or its salt. CONSTITUTION:The objective tablet is composed of an intermediate layer consisting of granules for tableting containing ibuprofen or its salt and, necessary, excipient, disintegrant, binder, lubricant and other drugs and an upper and a lower layers consisting of granules for tableting composed of an excipient. The tablet can be prepared without causing the troubles such as adhesion to tableting ram, creaking, adhesion to rotary disk, etc. The excipient is e.g. starch, carboxymethylcellulose, crystalline cellulose, lactose, talc or light silica. An antacid agent incompatible with ibuprofen can be used in the tablet by compounding to the upper and the lower layers.
The present invention relates to transformed EFG proteins with improved transdermal transmission, and a cosmetic composition for improving skin condition containing the proteins as an active ingredient. In addition, the present invention relates to a pharmaceutical composition for preventing or treating skin diseases containing the transformed EFG proteins as active ingredients. According to the present invention, the transformed EFG protein is bonded with a cell membrane to efficiently deliver EGF proteins into a cell, thereby increasing cell permeation rates and a half-life. In addition, since the shape of the transformed EGF protein is maintained intact even under harsh condition, thereby improving long-term stability. Further, the EGF protein may be effectively used in cosmetic composition and a pharmaceutical composition which have a short preserving period and are difficult to store and distribute due to protein denaturation. Therefore, the present invention may be used in a new cosmetic composition or a pharmaceutical composition with improved cell permeation rates, in vivo sustainability and stability, compared with existing EGF.
This will be a prospective, randomized, double-blinded study to compare the use of albumin versus lactated Ringer's solution in patients undergoing coronary artery bypass graft surgery and in patients undergoing aortic valve replacement surgery and evaluate the incidence of acute kidney injury as a primary outcome. Data will be collected from both EPIC and STS (society of thoracic surgeons) database. STS database extracts data from the electronic medical record and groups it in specific format to evaluate outcomes after cardiac surgery to compare institutional performance to similar institutions and the national average. Patients undergoing coronary artery bypass graft or aortic valve replacement will be randomized to receive either albumin or lactated Ringer's for fluid resuscitation post-surgery. The resuscitation volume will be based on clinical decision after examining all the hemodynamics parameters. This practice coincides with standard of care and current practice. All eligible patients will be randomly assigned to receive either albumin 5% or lactated Ringer's solution in a 1:1 ratio using computer-generated, permutated blocks of 2 - 4. Both solutions will be administered intravenously in 250 mL increments at the discretion of the physician until hemodynamic parameters are met. The IV infusion bag and IV tubing will be covered using opaque bags to allow for blinding.
PURPOSE:To obtain a ceramic member for a living body well bonded to bone tissue and not having possibility infected with bacteria by casting a dense material slurry and a porous material slurry in a mold so as to form two layers not mixed with each other and drying the cast slurries before baking. CONSTITUTION:When a tooth extraction cavity filler is prepared, at first, a beta-TCP powder becoming a raw material powder is synthesized using calcium carbonate and calcium hydrogen phosphate.dihydrate and heat-treated. Next, an ammonium polyacrylate type deflocculating agent and pure water are added to the above mentioned raw material powder and sufficiently mixed to prepare a uniform slurry and a foaming agent is subsequently added to foam said slurry to prepare a porous material slurry. An ammonium polyacrylate solution is added to the raw material powder and sufficiently mixed to prepare a uniform slurry to obtain a dense material slurry. Next, the porous material slurry is cast in a mold at first and the dense material slurry is subsequently cast in the mold so as not to be mixed with said porous material slurry to form two layers in the mold and these layers are dried at room temp. and subsequently baked.
Patients receive temoporfin IV over at least 6 minutes on day 1 and undergo interstitial photodynamic therapy on day 3. Within 4-6 weeks, patients undergo surgical resection.
This study is investigating a method to positively influence skin cancer prevention behaviors among melanoma survivors and their families. The first objective is to compare patient and familial sun exposure and cancer screening activity before and after a patient's diagnosis with primary cutaneous melanoma less than 4.0 mm in depth. It is believed that the diagnosis will positively affect behavior regarding skin cancer prevention as the diagnosis of melanoma makes the risk associated with sun-exposure and skin cancer a tangible issue. The second objective is to test whether receiving a "Melanoma Survivor" plaque and posting it in a melanoma survivor's bathroom will significantly affect the survivor's and broader family's sun exposure and cancer screening activity. Marketing research has shown similar techniques have been effective in causing individuals to consume goods (e.g. getting free pens with company logos makes you more likely to buy goods from that company), and the investigators think such techniques are transferable into the field of public health.
Intestinal pneumatosis (IN) is an uncommon radiological finding defined as the accumulation of air in the gastrointestinal tract wall. Its clinical signs are nonspecific and include symptoms such as diarrhea or abdominal pain. It includes benign entities (with subtle symptoms and the accumulation of air in the form of cysts that appear as clustered nodular lesions on the endoscopy, collapsible and soft); or severe cases (symptoms indicative of general health compromise and linear accumulation of air or free fluid suggestive of hollow viscus perforation); which require different management. We present the case of a patient diagnosed with benign intestinal pneumatosis (BIN), associated with anatomical changes due to a diaphragmatic hernia. CASE REPORT We report the case of an 86-year-old woman with a Morgani-Larrey congenital diaphragmatic hernia (HML) (2) admitted due to exacerbation of chronic baseline diarrhea. A colonoscopy with biopsies was performed, but the study was incomplete due to colonic torsion at the hepatic angle deriving from HML, with uncomplicated colonic mucosa and absence of cystic nodulations. Figure 1a. Biopsies ruled out organicity. The abdominal computed tomography (CT) scan performed revealed the accumulation of pneumoperitoneum bubbles in the distal ileum and suprahepatic wall without identification of continuity changes, or signs of visceral perforation. Figure 1b-c. The patient was diagnosed with BIN associated with an anatomical change (HML). Medical treatment was initiated with metronidazole at a dose of 1500 mg/day for 1 week, along with the patient's usual probiotics, and commercial compounds containing xyloglucan (pea protein) to restore the intestinal barrier function. (3). The patient was discharged with complete resolution of the diarrhea. No surgical intervention for her HML was required. DISCUSSION The clinical and radiological data in the presence of IN help us differentiate between severe cases and BIN, the latter being managed conservatively without the need for medical or surgical treatment. The intestinal barrier restoration measures implemented in our patient may have contributed to this resolution, although there is not enough scientific evidence to support this. The endoscopic image of nodular cysts is not always present in these cases, and the diagnosis of choice for this condition is radiological and based on exclusion. (4).
Experimental: RC1012 injection (allo-DNT Cells) The trial is divided into two parts: Part A1 is a single- dose escalation trial with three dose groups (5×10\^7 cells/kg, 1.5×10\^8 cells/kg, 4.5×10\^8 cells/kg), with 9-18 patients planned to be enrolled. Part A2 is a multiple-dose escalation trial consisting of 2 dose groups (1.5×10\^8 cells/kg and 4.5×10\^8 cells/ kg at day 0, day 7 and day 14), with 9-12 patients planned to be enrolled. Part B is a multiple-dose extension trial in which the Safety Review Committee evaluates whether to extend an additional 3-6 patients to receive the multiple cell infusions based on available PK and safety data.
Carotid artery atherosclerosis is one of the leading causes of stroke. Even though the association between the risk of stroke and the level of morphological stenosis of a carotid plaque has been known for a long time, growing evidence has since proven necessary to assess the composition of the plaque itself to identify vulnerability predictors. These vulnerable plaques, even more if non-stenosing, may be responsible for a significant - but hard to quantify - proportion of strokes so far classified cryptogenic. As a matter of fact, plaque composition may escape detection and characterisation with classical imaging. Several biomarkers associated with its vulnerability to destabilization and with the risk of stroke such as intraplaque hemorrhage and inflammation are now routinely assessable. After a few pathophysiological reminders and a critical reading of the historical literature concerning carotid artery atherosclerosis management, we will review in this article the imaging techniques that can be used in the routine work-up of a carotid atherosclerotic plaque, with a focus on vessel wall magnetic resonance imaging and contrast enhanced ultrasonography.
Dragonfly nymphs breathe water using tidal ventilation, a highly unusual strategy in water-breathing animals owing to the high viscosity, density and low oxygen (O2) concentration of water. This study examines how well these insects extract O2 from the surrounding water during progressive hypoxia. Nymphs were attached to a custom-designed respiro-spirometer to simultaneously measure tidal volume, ventilation frequency and metabolic rate. Oxygen extraction efficiencies (OEE) were calculated across four partial pressure of oxygen (pO2) treatments, from normoxia to severe hypoxia. While there was no significant change in tidal volume, ventilation frequency increased significantly from 9.4 ± 1.2 breaths per minute (BPM) at 21.3 kPa to 35.6 ± 2.9 BPM at 5.3 kPa. Metabolic rate increased significantly from 1.4 ± 0.3 µl O2 min-1 at 21.3 kPa to 2.1 ± 0.4 µl O2 min-1 at 16.0 kPa, but then returned to normoxic levels as O2 levels declined further. OEE of nymphs was 40.1 ± 6.1% at 21.3 kPa, and did not change significantly during hypoxia. Comparison to literature shows that nymphs maintain their OEE during hypoxia unlike other aquatic tidal-breathers and some unidirectional breathers. This result, and numerical models simulating experimental conditions, indicate that nymphs maintain these extraction efficiencies by increasing gill conductance and/or lowering internal pO2 to maintain a sufficient diffusion gradient across their respiratory surface.