anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicine formula for treating piles. The preparation comprises an externally-washed prescription and an orally-taken prescription, wherein the externally-washed prescription and the orally-taken prescription are combined for treatment. The externally-washed medicine mainly comprises Glauber's salt, zanthoxylum, radix sileris, coptis root, houttuynia cordata thunb., nutgall and the like. With 50 grams of preparation as a reference, the content of various components is as follows: 10 grams of zanthoxylum, 10 grams of radix sileris, 10 grams of houttuynia cordata thunb., 10 grams of nutgall, 5 grams of coptis root and 5 grams of Glauber's salt. The orally-taken medicine mainly comprises sophora japonica, garden burnet, rehmannia root, peony bark, honeysuckle flower, weeping forsythia, radix sileris, gardenia, red peony root, herba schizonepetae and the like. With 150 grams of preparation as a reference, the content of various components is as follows: 15 grams of sophora japonica, 15 grams of garden burnet, 15 grams of rehmannia root, 15 grams of honeysuckle flower, 10 grams of peony bark, 10 grams of weeping forsythia, 10 grams of radix sileris, 10 grams of gardenia, 10 grams of red peony root and 10 grams of herba schizonepetae. The traditional Chinese medicine formula fetures wide medicine source, easy material acquirement, simple preparation, no toxic or side effect and remarkable curative effect, is economical and practical and is suitable for the treating various patients.
PURPOSE:To provide a cosmetic and a histamine liberation-inhibiting agent inhibiting the inflammation and chromatosis of skin after burnt with sunlight, by containing the extracts of Aloe andongensis Bak. and/or Aloe brevifolia Mill. as active ingredients. CONSTITUTION:The plant bodies of Aloe andongensis Bak. and/or Aloe brevifolia Mill. are extracted with a solvent such as water or alcohol at the ordinary temperature or under heating and the obtained extract is subsequently added to a cosmetic in an amount of 0.001-20wt.%, preferably 0.01-10wt.%, based on the whole amount of the cosmetic as a solid content. An aloe multiplied by a tissue culturing method wherein the stem top portion or plant body of the aloe is cultured aseptically cultured in an artificial solid medium containing a plant hormone (e.g. benzyl adenine or kinetine) to form a multi-bud body is preferably employed as the above-mentioned aloe.
The investigators will retrospectively and prospectively collect total PYP scans that had been performed on suspected or diagnosed ATTR-CM patients in medical centers in Taiwan and follow-up at least 1 year. You are enrolled based on clinical suspicions such as "red-flag" signs using ultrasound, NT-pro BNP and clinical data according to the diagnostic algorithms. If you are with Grade 2 and 3 PYP myocardial uptake, genetic testing is arranged, serum and urine AL tests results will be confirmed. Before reading, the imaging quality will be evaluated (good quality, fair but interpretable, poor but interpretable, poor and insufficient for interpretation). All the images will be visually graded by experienced nuclear medicine physicians with consensus. It helps understand the real-world data.
To compare INTELLiVENT-ASV with conventional ventilation with respect to (i.) quality of ventilation; and (ii.) ICU nursing staff workload in an international cohort of participants receiving postoperative ventilation after cardiac surgery. This study will also determine the effects of INTELLiVENT-ASV on clinical outcomes, including (iii.) duration of postoperative ventilation and (iv.) length of stay in ICU.
Loving-kindness meditation (LKM) and mindfulness meditation, in which PAT is rooted, are derived from Buddhist practices that have been empirically shown to have applications in improving mental health. Throughout the 1990s and early 2000s, mindfulness based CBT was shown to decrease stress, negative affect, and chronic pain in both psychiatric and non-psychiatric subjects. Mindfulness-based therapy has since been shown to be effective for treating mood and anxiety disorders. Only recently has LKM been examined as an intervention for affective symptoms. This meditation practice seems to be particularly suited for reducing negative affect while also enhancing positive affect in individuals who show emotional dysregulation, such as people with dysthymic disorder. This notion is supported by experimental studies suggesting that LKM decreases anxiety and stress, positively influences emotional responses to neutral stimuli, and promotes positive emotions such as trust, love, hope, and compassion. Dr. Fredrickson, a prominent researcher and social psychologist who is the foremost expert in LKM will serve as an outside consultant for the development of the protocol. She is not listed as an official collaborator because she will not be in direct contact with the participant data that the investigators will collect.

The intervention the investigators plan to develop, Positive Affect Training (PAT), combines mindfulness and LKM, with a strong emphasis on the latter. The investigators will adopt strategies that have been described in a previous LKM protocol for trauma victims. The investigators contacted Dr. Kearney who shared his manual with us. Given the impressive effect LKM seems to have on generating positive, and attenuating negative affect in experimental studies, the investigators plan to test PAT as a method of improving positive affect. The current study aims to test the initial efficacy of PAT in individuals who report experiencing a low mood. The investigators hypothesize significant improvement in subjects' self-reported ratings of negative and positive affect as a result of the intervention.
Systems and methods for noninvasively determining the function capacity of the kidney are provided. In the methods, first contrast agent is injected into the vasculature of a subject. The contrast agent is to be bound with functioning glomeruli of the kidney of the subject. Then, the kidney is imaged with a magnetic resonance imaging (MRI) system to acquire MRI images of the kidney. In the images, signal magnitudes or phases of voxels of regions bound with the contrast agent are different from signal magnitudes or phases of voxels of regions not bound with the contrast agent. Afterwards, the function capacity of the kidney is determined using the MRI images. Lastly, a report of the function capacity of the kidney is generated.
Control Group. The cold pressure test will be apply to this group. The investigators will use a container with an outer part filled with ice and an inner part filled with water, both separated by a screen that prevents direct contact between the ice and the hand. The water will be regularly stirred to maintain the temperature near to 0.7ºC.
The patients belonging to the control groups of each subcategory will also receive an explanatory video with basic and light cervical mobilization exercises (Annex 12). This group of exercises will be made up of a series of cervical mobilization exercises that are performed without pain, smooth, controlled by the patients, and without forcing the angulations. They are performed seated, with the arms extended along the body and forearms and hands resting on the legs. The chair must be firm and comfortable. Head movements to the right and left, right and left lateral flexion of the cervical region, cervical flexion and extension will be performed. This exercise will be performed for 5 minutes 3 times a day and beginning in the first 24 postoperative hours.
FIELD: medicine, ophthalmology. SUBSTANCE: invention relates to agents prepared from vegetable raw. The proposed agent comprises bilberry fruits extract and accessory substances that comprise homeopathic supplements additionally taken among of order: eyebright (Euphrasia officinalis), evergreen Carolina jessamine (Gelsemium Juss.) and/or raceme-like bug-bane (Cimicifuga) in the following ratio of components in 100 g of ready product: bilberry fruits, 7.5-10.0 g; homeopathic supplements, 4.0-5.0 g; accessory supplements, the balance. Agent shows wide spectrum of effect: recovery, tonic and regenerative, ecologically pure and without irritating, allergic, inflammatory and other unfavorable effects and excluding mechanical contact with eye surface. EFFECT: valuable medicinal properties of agent. 7 cl, 4 tbl
This meta-analysis summarizes evidence from 44 neuroimaging experiments and characterizes the general linguistic network in early deaf individuals. Meta-analytic comparisons with hearing individuals found that a specific set of regions (in particular the left inferior frontal gyrus and posterior middle temporal gyrus) participates in supramodal language processing. In addition to previously described modality-specific differences, the present study showed that the left calcarine gyrus and the right caudate were additionally recruited in deaf compared with hearing individuals. In addition, this study showed that the bilateral posterior superior temporal gyrus is shaped by cross-modal plasticity, whereas the left frontotemporal areas are shaped by early language experience. Although an overall left-lateralized pattern for language processing was observed in the early deaf individuals, regional lateralization was altered in the inferior frontal gyrus and anterior temporal lobe. These findings indicate that the core language network functions in a modality-independent manner, and provide a foundation for determining the contributions of sensory and linguistic experiences in shaping the neural bases of language processing.
Subarachnoid hemorrhage often leads to poor outcomes owing to vasospasm, even after successful aneurysm treatment. Clazosentan, an endothelin receptor inhibitor, has been proven to be an effective treatment for vasospasms in a Japanese randomized controlled trial. However, its efficacy in older patients (≥ 75 years old) and those with World Federation of Neurosurgical Societies (WFNS) grade V has not been demonstrated. We retrospectively evaluated the efficacy of clazosentan in older patients and those with WFNS grade V, using real-world data. Patients with subarachnoid hemorrhage treated before and after the introduction of clazosentan were retrospectively evaluated. The patients were categorized into two groups (clazosentan era versus pre-clazosentan era), in which vasospasm management and outcomes were compared. Vasospasms were managed with fasudil hydrochloride-based (pre-clazosentan era) or clazosentan-based treatment (clazosentan era). Seventy-eight patients were included in this study: the clazosentan era (n = 32) and pre-clazosentan era (n = 46). Overall, clazosentan significantly reduced clinical vasospasms (clazosentan era: 31.3% versus pre-clazosentan era: 60.9%, p = 0.01), delayed cerebral ischemia (DCI) (9.4% versus 39.1%, p = 0.004), and vasospasm-related morbidity and mortality (M/M) (3.1% versus 19.6%, p = 0.03). In subgroup analysis of older patients or those with WFNS grade V, no significant difference was observed in clinical outcomes, although both DCI and vasospasm-related M/M were lower in the clazosentan era. Clazosentan was more effective than fasudil-based management in preventing DCI and reducing vasospasm-related M/M. Clazosentan could be used safely in older patients and those with WFNS grade V, although clinical outcomes in these patients were comparable to those of conventional treatment.
Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation.
AIMS: Transthyretin amyloid cardiomyopathy (ATTR-CM) is characterized by increased wall thickness, diastolic dysfunction and progressive heart failure symptoms. The disease may infiltrate the conduction system leading to conduction disturbances requiring an implantation of permanent cardiac pacemaker (PM), but the extent is unknown. Here, we report the prevalence of ATTR-CM in patients ≥65 years with PM.
METHODS AND RESULTS: In this prospective, cross-sectional single-centre study patients were recruited from our out-patient pacemaker clinic. Eligibility criteria were age above 65 years, permanent cardiac pacemaker and competent to give informed consent. Patients underwent echocardiography at the pacemaker visit and were referred to 99mTc-DPD-scintigraphy (DPD) and blood samples if septum thickness was ≥12 mm, defined as left ventricular hypertrophy (LVH). Fifty eight of the 128 patients had LVH on echocardiography. Eleven patients had a DPD-scintigraphy based diagnosis of ATTR-CM, which represent 19% of patients with LVH and 9% of the total cohort. Patients diagnosed with ATTR-CM had higher concentrations of cardiac biomarkers (P < 0.001), higher E/E' (P = 0.001), and lower global longitudinal strain (P = 0.003) on echocardiography and more heart failure symptoms (P = 0.001).
CONCLUSIONS: The prevalence of ATTR-CM in elderly patients with PM and LVH on echocardiography was 19%.
The Shoulder Instability-Return to Sports After Injury (SIRSI) scale is a useful psychological readiness tool to determine whether athletes are prepared to return to sport. Although questions remain on the optimal timing of survey administration based on the type of procedure (i.e., arthroscopic Bankart repair vs Latarjet procedure) and external factors contributing to psychological readiness, its current use begs the question of what other applications may be appropriate. The SIRSI scale has recently been able to effectively predict patient-reported and clinical outcomes, such as postoperative instability recurrence. However, it also may have added value as a serial screening tool for determining a safe return to preinjury activity rather than just serving as a harbinger of further negative outcomes after shoulder stabilization. Increasingly, we must recognize the fundamental limitations in our current rehabilitation pathways and sometimes myopic, 1-dimensional return-to-play criteria (e.g., range of motion or isokinetic testing) in facilitating a safe return to competition. We must transition to a more regimented, criteria-based return-to-play battery that incorporates optimized psychological readiness. As such, the SIRSI scale, like its anterior cruciate ligament counterpart, could become the standard of care in determining confidence in returning to sport and ultimately serve as a benchmark of surgical success.
PURPOSE:To obtain an ultraviolet protective which has a high transparency in the visible region, a high absorbing power in the ultraviolet region, and excellent corrosion resistance and ultraviolet protective properties and is useful as an external preparation for skin by using a silicon carbide powder with a specified particle size. CONSTITUTION:A silicon carbide powder with a particle size of 0.001-10mum is used. Pref. the powder gives an X-ray diffraction pattern corresponding to JCPDS file no. 4-756, etc., and still pref. is of a hexagonal crystal system, contains 0.50wt.% or lower free carbon and 0.1wt.% or lower iron or its compd., and has an L value of 75 or higher.
A method and software interface enables selective processing of data transmissions containing one or more medication orders intended for a pharmacy. Data transmissions are monitored and parsed for prescribed information which is utilized to populate a prescribed data structure. The data structure and parsing rules can be associated with a specific source that can be determined from the data transmission. The parsed data is tested against an order database to determine suitability for automated handling. If suitable, the medication preparation system prepares the medications identified by the data. Those portions of the data that are not suited for automated handling are released (e.g., from the parser). Further verification can be performed by determining the source of the data transmission and verifying it as a valid source. Data transmissions can be monitored over a network, within a network component, or in cooperation with another software program.
Use of polyamines (I) or their salts, solvates and physiologically hydrolyzable amides for treatment or prevention of alcoholism in humans. Use of polyamines of formula A-NH-(CH2)n-NH-B (I) or their salts, solvates and physiologically hydrolyzable amides for treatment or prevention of alcoholism in humans. A, B : H or 3-aminopropyl; and n : 3-4; provided that when n = 3, A and B = H. ACTIVITY : Antialcoholic; Antiaddictive. UChB rats, genetically predisposed to alcoholism, were provided with 10 % aqueous ethanol solution and water ad libitum during a reference period during which the amount of alcohol consumed was recorded. The animals were then given 2 mg/kg, intragastrically, of spermidine trihydrochloride on each of 3 days. The mean (n = 8) reduction in alcohol consumption was 25 % in the first 6 hours after treatment and 17 % in the 6 hours after treatment was stopped. MECHANISM OF ACTION : None given.
This study is being done to test the effect of a drug, nifurtimox, against neuroblastoma and medulloblastoma in children. Nifurtimox is a drug that has been used in South America for many years to treat a parasitic disease known as Chagas Disease. It is not approved by the Food and Drug Administration for routine use in neuroblastoma or medulloblastoma in the United States, but limited early observations suggest that nifurtimox may have anti tumor activity for neuroblastoma and medulloblastoma.

From the preliminary trials of nifurtimox we have determined a safely tolerated dose of nifurtimox to use in neuroblastoma patients (30mg/kg/day). The dose determined in the Phase I study to be safe, will be the dose used for this study. From clinical experience in South America, we know that children can tolerate nifurtimox when given by mouth, and it appears to have no long-term side effects when used to treat Chagas Disease. Based on our laboratory and animal studies, we believe that drug levels similar to those used to treat Chagas Disease may shrink/kill neuroblastoma cells, especially when combined with other chemotherapy drugs. We do not know whether nifurtimox will shrink/kill tumor cells effectively in children. Therefore, the major goal of the study is to learn if nifurtimox in combination with other chemotherapy drugs is effective in shrinking/killing neuroblastoma and medulloblastoma cells.
Trastuzumab has been administered to 386 patients who were 65 years of age or over (253 in the adjuvant treatment and 133 in metastatic breast cancer treatment settings). The risk of cardiac dysfunction was increased in geriatric patients as compared to younger patients in both those receiving treatment for metastatic disease in Studies 5 and 6, or adjuvant therapy in Studies 1 and 2. Limitations in data collection and differences in study design of the 4 studies of trastuzumab in adjuvant treatment of breast cancer preclude a determination of whether the toxicity profile of trastuzumab in older patients is different from younger patients. The reported clinical experience is not adequate to determine whether the efficacy improvements (ORR, TTP, OS, DFS) of trastuzumab treatment in older patients is different from that observed in patients < 65 years of age for metastatic disease and adjuvant treatment.

In Study 7 (metastatic gastric cancer), of the 294 patients treated with trastuzumab, 108 (37%) were 65 years of age or older, while 13 (4.4%) were 75 and over. No overall differences in safety or effectiveness were observed.
Osteoarthritis (OA) of the knee has become a major public health issue and imposes a significant healthcare burden and accounts for high annual hospitalizations. Chronic OA of the knee may lead to reduced physical fitness, mobility disability with a resultant increased risk of cardio-metabolic comorbidity and early mortality. Total knee arthroplasty (TKA) is indicated in severe cases to improve long-term pain and function. (1) TKA involves extensive bone resection as well as soft tissue excision and therefore is associated with profound postoperative pain. (2) Inadequate perioperative pain control may prolong hospitalization, hinder early rehabilitation, and is also a strong predictor of persistent pain beyond 3 months. (3) Adequate analgesia after TKA is therefore considered paramount to facilitate early hospital discharge and effective functional recovery. (4) The recently introduced adductor canal block (ACB) typically covers the anterio-medial aspect of the knee and preserves quadriceps function, which presumably enhances postoperative rehabilitation by allowing patients to actively participate in knee movement. The relative effectiveness of this ACB technique added to intrathecal morphine is limited to a single study (1) in which assessment of short-term functional recovery was done and dexamethasone was neither included in the LIA solution nor perineurally in the ACB. Thus, we hypothesize that adductor canal block as an adjunct to intrathecal morphine will have a better impact on functional recovery than peri-articular infiltration.
This arm will display similar text proposed in a recent sugary drink warning label bill in California. Sample text: WARNING: Drinking beverages with added sugar(s) contributes to obesity, type 2 diabetes, and tooth decay. The calorie label will also appear on all beverages.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. In particular, hepatocellular carcinoma (HCC) has become the most common primary hepatic malignancy. Current therapies are now satisfying and there is therefore an important need for identifying new therapeutic avenues. IL-27 is a cytokine produced in liver microenvironment but its role in the pathogenesis of HCC has never been investigated. The inventors now show that IL-27 exerts anti-proliferative activities in HCC cell lines. However, the inventors show that in patients suffering from HCC that a decreased expression of WSX-1 (i.e. the IL-27 receptor) is associated with a worse prognosis and contributes to the tumor proliferation. The inventors then identified some microRNAs (miR) that are capable of repressing the expression of WSX-1 and show that overexpression of said miR are associated with a worse prognosis in patients. Finally, the inventors demonstrate that antagomirs restore the expression of WSX-1 that can thus restore the tumor cell sensitization to IL-27 properties. Accordingly, the present invention relates to methods for the treatment and prognosis of cancer, in particular hepatocellular carcinoma (HCC).
The invention relates to the biotechnology, namely to the production of the dry bacillary preparation subtilis used for treating and preventing the gastrointestinal diseases of the young individuals of the cattle. The aim of the invention consists inimproving the quality, increasing the yield of the end product, and increasing its shelf time. The strain Bacillus subtilis BKIIM B-4099 is cultured in the bioreactor in the submerged mode. The selective medium containing all the required nutrients with high content of dry substances is used. The bacteria are cultured under continuous agitation and aeration. The bacterial mass is separated by ultracentrifugation at 15000 rpm and mixed with the protective medium. Then the end product is sublimated.