anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The proposed research plan focuses on the identification of changes in the structural and functional brain parameters (e.g. volume, brain activity), in response to a physical exercise (PE) protocol, on the neurocircuitry of addiction, after a 4 month-intervention program in college binge drinkers (BDs). The main objectives of this proposal are: O1) to evaluate the potential benefits of PE on the brain structure and function, particularly in the neurocircuitry of addiction, in a sample of Portuguese college students with a binge drinking pattern of alcohol use; and O2) to determine whether the PE intervention reduces craving and alcohol consumption levels in BDs. The present project will involve: i) a pre-intervention comprehensive evaluation of behavioral (alcohol consumption), psychological (craving levels), physiological (VO2, HRV), and neurological (neuroimaging) variables; ii) a training phase consisting of 48 sessions (3 weekly sessions\*16 weeks) of aerobic (exp group 1), agility-cognitive (exp group 2) exercise and stretching (control group; iii) a post-intervention evaluation of behavioral, physiological, and neurological (neuroimaging) variables; iv) and a 6 months' follow- up evaluation of behavioral, physiologicaln and cognitive variables. A randomized controlled trial will be implemented at the University of Minho. It will include a total of 60 college students with a binge drinking pattern of alcohol intake, 20 participants per condition.
Chronic venous insufficiency (CVI) is a chronic lower limb progressive disorder with significant burden. Graduated compression therapy is the gold-standard treatment, but its underutilisation, as indicated in recent literature, may be contributing to the growing burden of CVI. The aim of this systematic review is to determine the reasons for poor compliance in patients who are prescribed graduated compression therapy in the management of chronic venous insufficiency. A systematic review of the literature was conducted to identify the reasons for non-compliance in wearing graduated compression therapy in the management of chronic venous insufficiency. The keyword search was conducted through Medline, PubMed, CINAHL, Cochrane library, AMED, and Embase databases from 2000 to April 2023. Qualitative and quantitative studies were included with no study design or language limits imposed on the search. The study populations were restricted to adults aged over 18 years, diagnosed with chronic venous insufficiency. Of the 856 studies found, 80 full-text articles were reviewed, with 14 being eligible for the review. Due to the variability in study designs, the results were summarised rather than subjected to meta-analysis. There are five main overarching themes for non-compliance, which are physical limitations, health literacy, discomfort, financial issues, and psychosocial issues with emerging sub-themes. Graduated compression therapy has the potential to reduce the burden of chronic venous insufficiency if patients are more compliant with their prescription.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to solid rapidly decomposing carbonated composition of cetirizine. Rapidly decomposing carbonated composition for oral administration comprises cetirizine or its pharmaceutically tolerant salt, carbonated base comprising at least one organic food acid and/or its salt, alkaline and/or alkaline-earth metal carbonates or hydrocarbonates and optional pharmaceutically acceptable accessory substances. Invention provides preparing novel, therapeutically suitable, solid, rapidly decomposing carbonated compositions of cetirizine. EFFECT: improved and valuable properties of composition. 12 cl, 1 dwg
Despite being designed for smoking cessation, e-cigarettes and their variety of flavors have become increasingly attractive to teens and young adults. This trend has fueled concerns regarding the potential role of e-cigarettes in advancing chronic diseases, notably those affecting the cardiovascular system. E-cigarettes contain a mixture of metals and chemical compounds, some of which have been implicated in cardiovascular diseases like atherosclerosis. Our laboratory has optimized in vivo exposure regimens to mimic human vaping patterns. Using these established protocols in an inducible (AAV-PCSK9) hyperlipidemic mouse model, this study tests the hypothesis that a chronic exposure to e-cigarette aerosols will increase atherosclerotic plaques. The exposures were conducted using the SCIREQ InExpose™ nose-only inhalation system and STLTH or Vuse products for 16 weeks. We observed that only male mice exposed to STLTH or Vuse aerosols had significantly increased plasma total cholesterol, triglycerides, and LDL cholesterol levels compared to mice exposed to system air. Moreover, these male mice also had a significant increase in aortic and sinus plaque area. Male mice exposed to e-cigarette aerosol had a significant reduction in weight gain over the exposure period. Our data indicate that e-cigarette use in young hyperlipidemic male mice increases atherosclerosis in the absence of significant pulmonary and systemic inflammation. These results underscore the need for extensive research to unravel the long-term health effects of e-cigarettes.
Objective To examine the association of CRF and adiposity with cardiometabolic risk factors and metabolic syndrome among emerging adults. Participants: 5681 (60.1% Men; 21 ± 1years) college students from a large university located in the northeast of the United States. Methods: Participants completed an objective health assessment that involved the assessment cardiometabolic risk factors, CRF, and adiposity. Data of 5681 students' (60.1% Men; 21 ± 1years) who had CRF, adiposity, all risk factors necessary to determine metabolic syndrome evaluated were analyzed using logistic regression analyses. Results: Poor CRF and elevated adiposity were associated with cardiometabolic risk factors and metabolic syndrome regardless of sex, with the association between adiposity and risk factors found to be stronger compared to CRF. Conclusions: Targeted and tailored screening and interventions are urgently needed to reduce adiposity and increase CRF to avoid serious short and long-term negative health outcomes in this population.
The invention relates to a formula of tranilast emulsifiable paste and a preparation process thereof, has a treatment effect in the fields of keloid and hypertrophic scars, and belongs to the technical field of medicines. The formula of the tranilast cream comprises the following components in percentage by weight: 0.5 to 10 percent of tranilast; 15% -30% of cream matrix; 3% -5% of a thickening agent; and (4) purifying the balance of water. The cream base comprises oil phase liquid and water phase liquid. The preparation process comprises the following steps: preparing oil phase liquid; preparing an aqueous phase liquid; preparing an emulsified tranilast dispersion liquid and the like. The cream containing the tranilast component belongs to an external preparation form, and has no untoward effects such as laziness, cytotoxicity and the like. The topical application can penetrate scar tissue to take effect locally, and has higher drug concentration for scar target tissue.
Patients in the POS group will undergo ET under general anesthesia. After the surgery is done, patients will keep being intubated and mechanically ventilated for 6hrs, during which period the patients will be sedated with sedatives to maintain a BIS value of 50\~70 and Ramsay sedation score of 5 \~ 6. The SBP will be controlled between 120 \~ 180mmHg with vasoactive drugs. After 6hs, the patients will be recovered and extubated.
Hair is permanently waved or straightened by treating it with a urea-containing aqueous solution or emulsion of a mercapto compound, e.g. ammonium thioglycolate, or an organic sulphur compound which can split up to give a mercapto compound, e.g. dithiodiglycolide, carbaminyl thioglycolic acid and ethyl xanthogen acetic acid, having a pH of 5-9 and adding urease or a urease-containing substance before, during or after placing the hair on curlers or curling the hair on cut-to-size strips of absorbent material, e.g. paper or cotton fabric, impregnated with urease preparation solution.  The hair may be wetted with water, wound on to curlers with the inter position of a urease-containing paper and then wetted with an acid thioglycolate solution to which shortly before use urea has been added or the hair may be wetted with the acid urea-containing thioglycolate solution and curled in the urease-containing paper. Alternatively the hair may be curled in the urease-containing paper and wetted with a urea-containing thioglycolate solution the pH of which has been adjusted to a little below 7.  When urease-impregnated absorbent material strips are not used the urease or urease-containing substance is preferably added to the urea-containing aqueous solution or emulsion of the mercapto compound shortly before its application to the hair.  The action of the waving compositions may be increased by increasing the temperature by use of a drier or vaporizer.  The urease-containing substance may be soya bean powder or jack bean powder or the extracts of these powders from which insoluble constituents have been removed.  In hair straightening processes the reagents are preferably applied to the hair in the form of a cream and straightening may be promoted by combing.  The compositions used may also contain wetting agents, perfume oils, buffering substances, e.g. ammonium dihydrogen phosphate and citric acid, and thickening agents.  Specifications 453,700, 689,641, 723,917, 735,303 and 780,037 are referred to.
The invention discloses a baby eczema lotion and a preparation method thereof. The lotion comprises the components of, by weight: 50-100 parts of redroot gromwell, 45-90 parts of light-yellow sophora root, 30-100 parts of Taiwan angelica root, and 60-120 parts of fragrant solomonseal rhizome. According to the invention, on a basis of heat clearing and dampness eliminating of traditional baby eczema treatment, a blood-cooling and detoxifying method is adopted. Also, considering the characteristics of baby skins, blood-cooling detoxifying, wind-evil-dispelling, dampness-eliminating, heat-clearing, itching-relieving, and skin-moisturizing traditional Chinese medicines are adopted for preparing the lotion, such that baby skins can be moisturized when baby eczema is cured. No significant side effect is found currently. The invention also discloses a preparation method of the baby eczema lotion.
PURPOSE: The aim of the present study was to examine the relationship between perceived physical literacy and obesity-related outcomes among adolescents from Spain.
METHODS: This is a secondary cross-sectional analysis including a total sample of 845 Spanish adolescents (55.3% girls) aged 12-17 years from the Valle de Ricote (Region of Murcia) from the Eating Healthy and Daily Life Activities (EHDLA) project. Physical literacy was evaluated using the Spanish Perceived Physical Literacy Instrument for adolescents (S-PPLI). Body mass index was computed by taking the participants' body weight in kilograms and dividing it by the square of their height in meters, and body mass index (z score) and overweight/obesity and obesity were computed by the World Health Organization age- and sex-specific thresholds. Waist circumference was measured using a constant tension tape. Moreover, the waist-to-height ratio was calculated, and therefore, abdominal obesity was determined. Skinfold measurements were taken at the triceps and medial calf using calibrated steel calipers.
RESULTS: In general, the overall trend was downward (i.e., the higher the PPLI score the lower the obesity-related indicators), with the approximate significance of smooth terms being statistically significant for all models examined (p < 0.001). Adolescents with lower perceived physical literacy (PPL) showed the highest estimated marginal means of body mass index, body mass index z score, waist circumference, waist-to-height ratio, and skinfold (triceps and calf) and predictive probabilities of having excess weight, obesity, and abdominal obesity, while their counterparts with high PPL had the lowest. In addition, significant differences were observed for all the obesity-related indications between adolescents with low PPL and those with medium PPL (p-adjusted < 0.05 for all indicators), as well as with those with high PPL (p-adjusted < 0.05 for all indicators). Moreover, these significant differences were also shown for most indicators between adolescents with medium PPL and those with high PPL (except for obesity).
CONCLUSION: Physical literacy could play a crucial role in maintaining more desirable obesity-related outcomes in adolescents. Adolescents with high perceived physical literacy showed lower obesity-related indicators (i.e., body mass index, body mass index z score, waist circumference, waist-to-height ratio, skinfolds), as well as a lower probability of having excess weight, obesity, and abdominal obesity.
The invention discloses application of a targeted complement inhibitor in preparation of a medicament for improving cholestatic liver injury. The application of a targeted complement inhibitor CR2-Crry in preparing a medicament for improving cholestatic liver injury is disclosed, wherein the amino acid sequence of CR2-Crry is shown as SEQ ID NO. 1. The invention utilizes Complement receptor 2 (CR 2) to fuse C3 activation inhibitory factor Crry, combines the CR2 targeting to the Complement activation site, and utilizes Crry specificity to inhibit C3 activation, thereby inhibiting Complement system activation. By establishing a mouse cholestatic liver injury model and comparing the liver injury level change of a CR2-Cryy treatment group and a control group, the result proves that CR2-Crry can obviously improve cholestatic liver injury, inhibit inflammatory cell infiltration in liver, inhibit M1 type macrophage polarization in liver and reduce proinflammatory factor expression. The invention further verifies the improvement effect of the inhibition of a complement system on cholestatic liver injury through a C3 gene knockout mouse.
PURPOSE:Novel lake pigment useful as a coloring matter, e.g., cosmetic, etc., insoluble in water or solvents, pulverizable, having opacifying power, obtained by covering the surface of white inorganic pigment particles with a reaction product of a metal polymer and organic dyestuff. CONSTITUTION:White inorganic pigment particles, e.g., titanium oxide, etc. are added to an aqueous solution obtained by dissovling a metal compound, e.g., aluminum hydroxide, etc. in water and dispersed. The same metal as that of the above- mentioned metal compound is dissolved in the solution. The solution is then reacted with an aqueous solution of metallic soap such as aluminum monostearate, etc. and/ or anionic surface active agent such as ammonium stearate, etc., and the reaction product is aged. The reaction product is then reacted with an organic dyestuff, e.g., red 104-1, etc.
Loss of retinal ganglion cells (RGCs) is a primary cause of visual impairment in glaucoma, the pathological process is closely related to neuroinflammation and apoptosis. B-cell activating factor (BAFF) is a fundamental survival factor mainly expressed in the B cell lineage. Evidence suggests its neuroprotective effect, but the expression and role in the retina have not yet been investigated. In this study, we adopt optic nerve crush (ONC) as an in vivo model and oxygen-glucose deprivation/reoxygenation (OGD/R) of RGCs as an in vitro model to investigate the expression and function of BAFF. We found that BAFF and its receptors were abundantly expressed in the retina and BAFF inhibition exacerbated the caspase 3-mediated RGCs apoptosis, glial cell activation and pro-inflammatory cytokines expression, which may be caused by the activation of the NF-κB pathway in vivo. In addition, we found that BAFF treatment could alleviate RGCs apoptosis, pro-inflammatory cytokines expression and NF-κB pathway activation, which could be reversed the effect by blockade of the NF-κB pathway in vitro. Meanwhile, we found that microglia induced to overexpress BAFF in the inflammatory microenvironment in a time-dependent manner. Taken together, our results indicated that BAFF deficiency promoted RGCs apoptosis and neuroinflammation through activation of NF-κB pathway in ONC retinas, suggesting that BAFF may serve as a promising therapeutic target for the treatment of glaucoma.
In subjects allocated to the warm saline group, a thermos flask, which was filled with heated sterile water, was used. A 1000 ml bottle of sterile water was heated to 60 ˚C in a stove for an hour at minimum. Just before introducing into the abdominal cavity, the laparoscope was placed into the thermos flask for 30 seconds at minimum . After each incidence of laparoscopic lens fogging (LLF), the scope was briefly inserted into the thermos flask about 10 seconds, and was then wrapped gauze around the lens before abdominal reinsertion.
Historical chart review of patients from the Blood and Marrow Transplant database who received myeloablative allogeneic stem cell/bone marrow transplantation followed by standard GVHD prophylaxis in the past 10 years. Participants received allopurinol per institutional guidelines.
This is a single arm, open-label, single-center study. This study is indicated for relapsed or refractory CD19+ B-line hematological malignancy involved in CNS. All together 20 patients were enrolled. Primary objective is to explore the safety including the complication of cytokine release syndrome, CRES, pancytopenia and infection. The secondary objective is to explore the efficacy. We will also detect CAR-T cell expansion dynamics in blood and cerebral fluid and compare the difference.
A 79-year-old male patient with type 2 diabetic nephropathy and hypertension was admitted to our hospital because of acute kidney injury with significantly elevated serum creatinine (8.12 mg/dL) and urinary β2-microglobulin (β2MG, 31,748 μg/L) levels. α-glucosidase inhibitor (α-GI) miglitol, started two weeks prior to presentation, was discontinued because drug-induced acute interstitial nephritis (AIN) was suspected. Renal biopsy revealed AIN and diabetic nephropathy. The drug-induced lymphocyte stimulation test for miglitol was also positive. After the discontinuation of miglitol, the urinary β2MG levels decreased to the normal range. This case raises the possibility that α-GI miglitol can worsen the renal function in patients with underlying renal dysfunction.
This group received triple standard therapy with standard doses of omeprazole. 20 mg "omeprazole" before breakfast and before dinner. 500 mg "clarithromycin" after breakfast and after dinner and 1 g "amoxicillin" after breakfast and after dinner for 10 days.
Provided are an organopolysiloxane having a catechol structure in a molecule thereof, and a powder treatment agent that is formed from said organopolysiloxane and that provides a dispersion having excellent dispersibility, fluidity, and temporal stability.　This catechol functional organopolysiloxane is represented by formula (1).　(In formula (1), each R 1  independently represents an unsubstituted or substituted C1-6 monovalent hydrocarbon group, each R 2  independently represents an unsubstituted or substituted C1-6 monovalent hydrocarbon group or represents a substituent represented by formula (2), a, b, c, and d each represent 0 or a positive number, and a+b+c+d equals 2 to 1,000. At least one R 2  per molecule is a substituent represented by formula (2). In formula (1), an oxygen atom of each repeating unit of formula (1) is shared with another repeating unit.) (In formula (2), Y 1  represents an unsubstituted or substituted C2-6 divalent hydrocarbon group. In formula (2), the atomic bond delimited by the wavy line is bound to a silicon atom in formula (1).)
Participants will receive an SC injection of TV-46000 at baseline and q4w thereafter. The maximal dose for adult participants is comparable to an oral risperidone dose of 5 milligrams (mg)/day, and the maximal dose for adolescents is comparable to 4 mg/day. Participants will continue treatment until they experience a relapse event; meet 1 or more of the study discontinuation or withdrawal criteria; or remain relapse-free during the double-blind phase until the study is terminated.
Mitochondria are crucial organelles that play a central role in cellular metabolism and programmed cell death in eukaryotic cells. Mitochondrial autophagy (mitophagy) is a selective process where damaged mitochondria are encapsulated and degraded through autophagic mechanisms, ensuring the maintenance of both mitochondrial and cellular homeostasis. Excessive programmed cell death in neurons can result in functional impairments following cerebral ischemia and trauma, as well as in chronic neurodegenerative diseases, leading to irreversible declines in motor and cognitive functions. Neuroinflammation, an inflammatory response of the central nervous system to factors disrupting homeostasis, is a common feature across various neurological events, including ischemic, infectious, traumatic, and neurodegenerative conditions. Emerging research suggests that regulating autophagy may offer a promising therapeutic avenue for treating certain neurological diseases. Furthermore, existing literature indicates that various small molecule autophagy regulators have been tested in animal models and are linked to neurological disease outcomes. This review explores the role of mitophagy in programmed neuronal death and its connection to neuroinflammation.
The invention belongs to the technical field of medicines and particularly relates to a ganciclovir crystal compound, a new composition thereof and a preparation method thereof. The ganciclovir is a crystal. The X-ray powder, measured by Cu-Kalpha ray, of the ganciclovir crystal is diffracted to display characteristic peaks when 2 theta equals to 30 DEG, 35 DEG, 50 DEG, 60 DEG, 63 DEG or 74.5 DEG. The grain size of the ganciclovir crystal is 85 to 105 microns. The invention also relates to a ganciclovir medicinal composition. The medicinal composition is a ganciclovir freeze-dried preparation. The ganciclovir freeze-dried preparation comprises ganciclovir, sodium chloride and sodium hydroxide. In the preparation process, the freeze-drying process is controlled strictly. The prepared freeze-dried powder injection is stable, low in related substance and high in redissolving property.
The present invention relates to a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating or treating steatohepatitis, comprising a curcumin derivative and a TGF-? receptor inhibitor as active ingredients. In the composition, the TGF-? receptor inhibitor inhibits the fibrosis of liver tissue, and the curcumin derivative inhibits the adipogenesis of hepatocytes increased during the fibrosis inhibition process. Thus, compared to when a curcumin derivative or a TGF-? receptor inhibitor is administered alone as in the conventional cases, the composition exhibits an excellent effect of preventing and treating steatohepatitis, and therefore, can be used as a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating or treating metabolic liver diseases, including steatohepatitis.