anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition containing natural plant extract is provided to lower the activation of glutamic acid pyruvic acid transaminase(GPT) and glutamic acid oxaloacetic acid transaminase(GOT). CONSTITUTION: A composition for improving liver function contains Acanthopanax koreanum peel extract or Cnidium officinale extract as an active ingredient. The extracts are hot water extract. The composition is a food composition or pharmaceutical composition. The food composition also contains sweetener, flavoring agent, physiological ingredient, and mineral. The physiologically active ingredient is catechins, retinols, ascorbic acid, tocopherol, and rivoflavin.
Negative SRH outcomes (e.g., sexually transmitted infections \[STIs\], unintended pregnancy, STI-related cancers) reduce human performance and undermine military readiness. Service members face unique challenges to maintaining SRH during their military service. HRSBs (e.g., multiple sexual partners, unprotected sexual behavior) offer potential intervention targets to improve SRH. Electronic-health interventions are cost-effective and dynamic, and have the potential to reach millions of users as part of an overall strategy for individual behavior and systems change. In civilian populations, e-health interventions have demonstrated success in reducing HRSBs. However, effective HRSB-prevention interventions must consider the specific values, mission, and context of military populations and settings. The MOST framework is used to develop highly effective, efficient, and economic behavioral interventions that is particularly well suited to be used in this context.

This project aims to address this problem by delivering an optimized app-based prevention intervention package ready for evaluation via a subsequent randomized controlled trial (RCT). The specific purpose of this project is to determine which component(s) should be included in the packaged app-based intervention Mission Wellness for US service members based on their effects on the outcomes of interest (i.e., improved knowledge, motivation, and behavior skills related to SRH and reduced HRSBs) in no more than 25 minutes of content. The components tested in the factorial CSEs include: Narratives; Skills; Scenarios; Future; and Risk. Each component has two levels: "on" (included) or "off" (not included). Main and interaction effects of components will be measured to determine the components constituting the packaged intervention.
BACKGROUND: To assess the long-term incidence and risk factors for post-keratoplasty infectious keratitis (IK), associated ocular pathogens, and antibiotic resistance profiles.
METHODS: Cohort study including 2553 consecutive penetrating, endothelial, and anterior lamellar keratoplasties performed between 1992 and 2020. Medical and microbiological records of patients clinically diagnosed with IK were retrospectively reviewed.
MAIN OUTCOME MEASURES: cumulative incidence of IK, infectious agent species, and antibiotics resistance profiles.
RESULTS: The average follow-up time after transplantation was 112 ± 96 months. Eighty-nine IK episodes were recorded; microbiological tests were positive in 55/89 (62%). The cumulated incidence of postoperative IK was 5.50%/10.25% at 10/20 years. The occurrence of at least one episode of IK after transplantation was associated with lower graft survival in the long term (p < 0.0001). Rejection risk (adjusted Hazard Ratio, 2.29) and postoperative epithelial complications (HR, 3.44) were significantly and independently associated with a higher incidence of postoperative IK. Infectious agents included 41 bacteria, 10 HSV, 6 fungi, and 1 Acanthamoeba. The rate of antibiotic resistance was 0% for vancomycin, 13% for fluoroquinolones, 20% for rifamycin, 59% for aminoglycosides, and 73% for ticarcillin. In 41% of cases, patients were under prophylactic topical antibiotics before the infectious episode. Topical antibiotics were significantly associated with increased resistance to penicillin, carbapenems, and aminoglycosides.
CONCLUSION: IK (mainly bacterial) is a frequent complication of corneal transplantation in the long term. Vancomycin and fluoroquinolones can be considered as first-line treatments. Prolonged postoperative antibiotic preventive treatment is not advisable as it may increase antibiotic resistance.
BACKGROUND: This study assessed the effectiveness of the dural puncture epidural (DPE) technique in managing breakthrough pain in parous women receiving labor analgesia during induced labor.
METHODS: This single-center retrospective cohort study included term pregnant women with singleton pregnancies who received treatment for breakthrough pain during labor. All participants underwent induced labor, and some parous women among them underwent DPE. The DPE technique consisted of placing an epidural catheter after dural puncture with a 27-gauge spinal needle. Eligible women were allocated into a DPE group and conventional epidural (CE) anesthesia group. Pain was assessed with a numerical rating scale (NRS), and a patient-controlled epidural analgesia (PCEA) bolus was administered when the NRS score was ≥3. Breakthrough pain was defined as an NRS score ≥3 during PCEA management. The primary outcome was the efficacy of rescue interventions in managing breakthrough pain, as determined by a reduction in pain intensity to an NRS score <3 before birth.
RESULTS: Among the 55 parous women who received labor analgesia, 44 required additional rescue administration for breakthrough pain. Of the remaining women, 23 received DPE and 19 received CE anesthesia. The DPE group experienced significantly more effective relief of breakthrough pain before birth than did the CE group (DPE: 100%; CE: 68.4%; p=0.005).
CONCLUSION: In parous women, DPE anesthesia was more effective than CE anesthesia in providing analgesia for breakthrough pain immediately before delivery during induced labor.
<P>PROBLEM TO BE SOLVED: To provide a vaccine, preferably for human use, for symptom relaxant or prevention of evoked IgE-mediated allergic reactions.  <P>SOLUTION: This vaccine contains a protein having the entire amino acid sequence of constant C<SB>H</SB>2-C<SB>H</SB>3 domains in the epsilon chain of an IgE molecule or a structurally stable unit of the amino acid sequence, the protein optionally being coupled to one or more heterologous carrier proteins, and optionally containing an adjuvant. The vaccine is injected, with or without adjuvant, to raise the concentration of endogenous anti-IgE antibodies in the plasma of allergy subjects. In practice, the vaccine can be used against all types of IgE-mediated allergies since the antibodies are not dependent on the antigen specificity of the IgE molecule but can reduce the total IgE pool of the subject. Therefore, the vaccine is aimed at being used for treatment of subjects having different types of IgE-mediated allergies.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
PURPOSE:A drug and food and drink effective for remedying diseases such as hysteromyoma, hysteroptosis, metrocele, etc., containing papain and citric acid. CONSTITUTION:A composition containing 20-100wt% papain and citric acid in a remedy or 5-10wt% papain and citric acid in food and drink. Papain and citric acid are in a powdery or granular state and a ratio of them is 0.05-20pts.wt., especially 0.5-5pts.wt. of the latter to 1pt.wt. of the former. The composition is more easily drinkable than a composition containing citric acid only, the effects are developed in an extremely short time and are extremely prominent.
Chronic constipation, which is common and often difficult to treat, has numerous origins, including neurological and other conditions, and adverse reactions to drugs, especially opioids. Chronic functional constipation lacks a clear underlying cause. Increasing evidence suggests that transanal irrigation (TAI) aids faecal evacuation and is well tolerated in many people with bowel dysfunction who do not adequately respond to first-line treatments. Recent papers offer insights that help nurses and other healthcare professionals implement best practice in the community, including discussing any need for assistance before starting TAI, agreeing the most appropriate device with patients and optimising the irrigation protocol. Training, careful follow-up and ongoing supervision improve adherence and success. Further studies are needed, however, and patients who do not respond adequately or are unable to tolerate TAI should be referred to a specialist service.
Patients in the PSY group will participate to a short-term group psychotherapy with elements of music therapy; meetings will be 1 / week, for a total of 6 weeks. Beginning of psychotherapy intervention will be 1-2 weeks after recruitment at T0 and will therefore cover the entire duration of the RT cycle.
All patients will undergo a caloric restriction diet for a week.This begins with the intake of a laxative fluid on the first fasting day. This fluid aids in bowel emptying, akin to preparations for a colonoscopy. Detailed instructions on how to use it will be provided along with the laxative, and the study physician or dietary team will discuss dosage and intake with you. The caloric restriction period will last for 7 days and then be broken with the consumption of an apple. Following the breaking of the fast, three build-up days will follow to gradually increase food intake.
<P>PROBLEM TO BE SOLVED: To provide ingredients which are important blood type determining constituent substances affording an important substance for a human metabolic pathway without difficulty by permeating and dissolving the ingredients in humor such as blood in the similar manner as that of intravenous drip according to drinking or external use for maintaining health or as therapy for intractable diseases in modern scientific medicines by utilizing the safe active ingredients of seaweeds and usable for dogs, cats, etc., and to produce wonderful effects when utilized as a raw material for cosmetics.  <P>SOLUTION: The seaweeds brown algae as a raw material are formulated with an acidic substance citric acid as a shocking agent and a masking agent, a cell wall sugar, a mucilaginous sugar, a stored sugar, etc., an ultralow-molecular microcolloid, an aqueous solution of citric acid to provide citric acid solution-ultralow-molecular polysaccharide extract No.1. Orthophosphoric acid is added to the citric acid solution-ultralow-molecular polysaccharide extract No.1 to simultaneously carry out ultralow-molecular hydrolysis and catalytic reactions with an enzyme. A substance mainly composed of β-L-fucose 1-phosphate/uronic acid/β-D- Glc-(1,3) β-D-Glc-(1,6) is obtained. Chamaecyparis obtusa oil/Aloe extract is additionally added thereto to afford citric acid solution-ultralow-molecular polysaccharide extract No.2. Bis-β- ethylcarbonic acid germanium sesquioxide + N-acetyl-L-cystene is added to the citric acid solution-ultralow-molecular polysaccharide extract No.2 to provide citric acid solution-ultralow- molecular polysaccharide extract No.3.  <P>COPYRIGHT: (C)2004,JPO
New discoveries for hearing loss intervention are often impeded by the proprietary nature of commercial hearing aids and their use in scientific research as "black boxes". An open-source hearing aid (open-source speech platform or OSP) was developed to bridge the gap between audiology research and the commercialization of hearing aid technologies and to promote innovative solutions to meet the needs of the hearing loss community. The OSP can replicate functions found in commercial hearing aids, and provides tools to researchers and listeners to access those functions. The purpose of this study is to evaluate portable and cloud-based platforms of the OSP that will enable a wide range of lab and field applications by measuring speech perception abilities with the open-source hearing aid in quiet and in noise for adults with and without hearing loss.

The study is a within-subjects design that allows for the comparison of outcomes within the same participant. The study will compare performance with two platforms of the open-source hearing aid (portable and cloud-based) for adults with hearing loss and normal hearing. The study will measure performance using tests of word identification. We will test aided performance with clinically validated hearing aid settings in quiet and in noise. Each participant will be presented with all the test conditions, and the order of presentation of the test conditions will be randomized across participants. Statistical analyses will use a repeated measures model to control for correlation between outcomes for the same participant.
The control group receives the usual care from the preschool oral health programme. The usual care is described as a DT team visiting the school to do an oral examination, provides OHE to the children, and applies fluoride varnish (20,000 ppmF) twice/year.
Studies indicate that buspirone is less sedating than other anxiolytics and that it does not produce significant functional impairment. However, its CNS effects in any individual patient may not be predictable. Therefore, patients should be cautioned about operating an automobile or using complex machinery until they are reasonably certain that buspirone treatment does not affect them adversely.

While formal studies of the interaction of buspirone hydrochloride with alcohol indicate that buspirone does not increase alcohol-induced impairment in motor and mental performance, it is prudent to avoid concomitant use of alcohol and buspirone.

Potential for Withdrawal Reactions in Sedative/Hypnotic/Anxiolytic Drug-Dependent Patients

Because buspirone does not exhibit cross-tolerance with benzodiazepines and other common sedative/hypnotic drugs, it will not block the withdrawal syndrome often seen with cessation of therapy with these drugs. Therefore, before starting therapy with buspirone, it is advisable to withdraw patients gradually, especially patients who have been using a CNS-depressant drug chronically, from their prior treatment. Rebound or withdrawal symptoms may occur over varying time periods, depending in part on the type of drug, and its effective half-life of elimination.

The syndrome of withdrawal from sedative/hypnotic/anxiolytic drugs can appear as any combination of irritability, anxiety, agitation, insomnia, tremor, abdominal cramps, muscle cramps, vomiting, sweating, flu-like symptoms without fever, and occasionally, even as seizures.
BACKGROUND: Chromosomal rearrangements involving one of the NTRK genes result in oncogenic driver mutations in thyroid carcinoma (TC) and serve as a target for therapy. We compared the clinicopathologic features of thyroid carcinomas with NTRK fusions vs. thyroid neoplasms with other malignancy associated gene fusions within our institution.
MATERIALS AND METHODS: Our pathology archives were searched from 2013 to 2023 for thyroid neoplasms with gene fusions, excluding THADA fusions and medullary thyroid carcinomas.
RESULTS: 55 thyroid lesions were identified: 22 with NTRK fusions (NTRK cohort) and 33 with other fusions (non-NTRK cohort). On fine needle aspiration (FNA), 54% of the NTRK cohort were classified as Category V as per Bethesda System for Reporting Thyroid Cytology (TBSRTC) and 51.5% of non-NTRK cohort as TBSRTC Category III. In the NTRK cohort, the most common reported fusion was ETV6::NTRK3 and the most common reported fusion in the non-NTRK cohort was PAX8::PPAR-gamma. On histologic examination both cohorts were most commonly diagnosed as PTC follicular variant. Invasive features were more common in the NTRK cohort in comparison to the non-NTRK cohort. Locoregional recurrence occurred in 2/22 NTRK cases and 2/33 non-NTRK cases, with average time from surgery to recurrence being 5.5 months and 21 months, respectively. The majority of patients in both groups are alive with no evidence of disease.
CONCLUSIONS: Thyroid neoplasms with a malignancy associated gene fusion are likely to be diagnosed as subtype/variant of PTC. Patients whose thyroid lesions harbor NTRK fusions present with a PTC-FV that on presentation has more aggressive clinicopathologic findings and are likely to have earlier disease recurrence.
The invention provides rapeseed peptide and application thereof in preparation of a drug nano-carrier, and relates to the technical field of biomedical materials. The sequence of the rapeseed peptide is shown as SEQ ID NO. 1, and can be applied to the preparation of drug nano-carriers. The invention also provides a method for preparing an anti-tumor drug by taking the polypeptide as a carrier, which comprises the following steps: and sequentially dissolving the rapeseed peptide and the antitumor drug in chloroform to obtain a mixed solution A. And (3) dropwise adding the mixed solution A into a phosphate buffer solution, then adding tween 80, and uniformly stirring to obtain a mixed solution B. Removing chloroform from the mixed solution B to obtain the antitumor drug. The rapeseed peptide is an excellent nano carrier of an anti-tumor drug, has high embedding rate on the drug, and obviously reduces the IC of the drug  50  The dosage of the medicine is reduced.
Olfactory dysfunction, influenced by factors such as aging and environmental stress, is linked to various neurological disorders. The olfactory bulb's connections to brain areas like the hypothalamus, piriform cortex, entorhinal cortex, and limbic system make olfactory dysfunction a contributor to a range of neuropathological conditions. Recent research has underscored that olfactory deficits are prevalent in individuals with both metabolic syndrome and dementia. These systemic metabolic alterations correlate with olfactory impairments, potentially affecting brain regions associated with the olfactory bulb. In cases of metabolic syndrome, phenomena such as insulin resistance and disrupted glucose metabolism may result in compromised olfactory function, leading to multiple neurological issues. This review synthesizes key findings on the interplay between metabolic-induced olfactory dysfunction and neuropathology. It emphasizes the critical role of olfactory assessment in diagnosing and managing neurological diseases related to metabolic syndrome.
BACKGROUND: The objective of this study was to determine the effects of royal jelly and fermented soy extracts on menopausal symptoms and on quality of life in pre- and post-menopausal women.
MATERIALS AND METHOD: This prospective observational study was carried out in a Clinical Hospital of Brasov, Romania, during June 2020 and December 2021. Eighty pre- and post-menopausal women, aged between 45 and 60 years, were included in two groups. The first group (40 women) received a dietary supplement with fermented soy extract twice a day for eight weeks and the second group (40 women) received the same dietary supplement with fermented soy extracts and 1500 mg of royal jelly capsules for eight weeks. After the treatment, the MENQOL score, DASS-21 score, and the mean number and intensity of daily hot flushes were recorded and compared with baseline values.
RESULTS: After eight weeks of treatment, the score of the MENQOL questionnaire and all its domains' scores decreased in comparison with the baseline in both groups (p < 0.001). Also, the DASS-21 score (p < 0.001), depression score (p < 0.001), anxiety score (p < 0.001), and stress score (p < 0.001) improved. The mean number and the intensity of hot flushes decreased in both groups (p < 0.001). Comparing these variables after the treatment in both groups, we observed that the women who received dietary supplements with fermented soy extracts and royal jelly capsules recorded better scores for MENQOL (vasomotor, physical, and psychosocial domains) and a more reduced mean number of daily hot flushes.
CONCLUSIONS: This observational study suggests that both dietary fermented soy supplements and royal jelly capsules possess beneficial effects against menopausal symptoms, increase the quality of life in pre- and post-menopausal women, and that the effects might be significantly improved if those dietary supplements are administered in association.
The invention discloses a traditional Chinese medicine composition for treating cough and a preparation method thereof. The medicine comprises common goldenrod, litchi leaves at the bottoms of ponds, gallbladders of carps, nails, small herb of nutgrass galingale, blood of crocodiles, herb of creeping waterprimrose, amphibious crab, bark of Buddhist bauhinia, wood of pungent litse, peel of sweet orange, ovientvine, sterculia nobililis and longan mistletoe. The preparation method comprises the following steps: weighing the components according to the parts by weight; grinding the nails into powder, drying the amphibious crab and ovientvine in the sun and putting the processed components in a pot together to be stir-fried with big fire for 2-5 minutes for later use; adding other components except the gallbladders of carps to the pot in the step B and adding water 10-20 times the components to decoct the components for 20-120 minutes; adding the bile of the gallbladders of carps to the step C, thus obtaining the composition. The invention aims to provide the traditional Chinese medicine composition for treating cough to overcome the defects in the prior art. The traditional Chinese medicine composition is reasonable in proportion and has quick curative effects. The invention also aims to provide the method for preparing the traditional Chinese medicine composition for treating cough.
Patients from groups 1b took the study product once a day in doses 60 mg per os and saline solution subcutaneously. Dose was blinded for a patient and investigator (double-blind method) using six tablets for each administration, some of them contained Dimolegin - DD217, and others were masked as Placebo of the study product.
The invention relates to a pygmy water lily and white tea clarifying lotion. The active ingredients of the pygmy water lily and white tea clarifying lotion are pygmy water lily petals, a pygmy water lily active extracting solution, a white tea extracting solution, avocado oil and sodium lactate. The pygmy water lily and white tea clarifying lotion is prepared from the active ingredients by adopting special process equipment. The pygmy water lily and white tea clarifying lotion belongs to the technical field of cosmetics. The pygmy water lily and white tea clarifying lotion is mainly used for daily skin care to brighten the skin and resist oxidation and can be used for deeply moisturizing the cells and repairing the damaged skin. The pygmy water lily and white tea clarifying lotion has the advantages that (1) the pygmy water lily and white tea clarifying lotion has the faint scent of the pure natural pygmy water lily, has clear and bright color and comprises whitening and freckle removing ingredients, so that the whitening and freckle removing effects are excellent; (2) the pygmy water lily and white tea clarifying lotion achieves the functions of brightening the skin, calming and whitening the skin, removing freckles and preventing skin allergy while moisturizing; (3) various plant essences have synergistic effects, so that the effects of various ingredients are maximized; (4) the pygmy water lily and white tea clarifying lotion is suitable for the crowd with various skins to use, is convenient to carry, has high cost performance and is environment-friendly.