anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of this study is to reveal the molecular changes accompanying the neuronal hyper-excitability during lipopolysaccharide (LPS)-induced systemic inflammation on rat hippocampus using Fourier transform infrared (FTIR) spectroscopy. For this aim, the body temperature of Wistar albino rats administered LPS or saline was recorded by radiotelemetry. The animals were decapitated when their body temperature began to decrease by 0.5°C after LPS treatment and the hippocampi of them were examined by FTIR spectroscopy. The results indicated that systemic inflammation caused lipid peroxidation, an increase in the amounts of lipids, proteins and nucleic acids, a decrease in membrane order, an increase in membrane dynamics and changes in the secondary structure of proteins. Principal component analysis successfully separated control and LPS-treated groups. In conclusion, significant structural, compositional and functional alterations occur in the hippocampus during systemic inflammation and these changes may have specific characteristics which can lead to neuronal hyper-excitability.
The invention discloses an aptamer for specifically recognizing soluble ST2 protein and application thereof, belonging to the field of variation or genetic engineering. The technical problem to be solved by the invention is how to specifically detect the sST2 protein. To solve the technical problem, the present invention provides an aptamer of single-stranded DNA having nucleotide sequences of SEQ ID Nos. 1 to 10, respectively. The invention adopts SELEX technology, combines high-throughput sequencing technology and bioinformatics analysis, reduces the screening times, obtains candidate aptamers, and obtains the aptamers capable of specifically recognizing sST2 protein by further analyzing the affinity and specificity of the candidate aptamers. The aptamer has the characteristics of high specificity, high stability, convenience in synthesis, easiness in labeling functional groups and the like, and can be used for detection of sST2 protein and preparation of products such as biosensors, diagnosis and prognosis of cardiovascular diseases and the like.
A standard blood pressure cuff will be placed on the right or left thigh, depending on the affected side, to occlude blood flow. The cuff will be inflated to 225 mmHg to prevent blood flow. Each session will consist of 4 cycles of 5 minute IPC applications, followed by 5 minutes of reperfusion for a total of 35 minutes.
The inventive probiotic composition based on the enterococcus strain relates to novel treatment means for preventing and curing bacterial and viral infections and dysbacteriosis of mucosa and skin and can be used for pharmacology, medicine and cosmetology. Said invention also relates to microbiology, in particular to the strains of the bacteria-enterococcus used in medical and food biotechnology. Said strains exhibit high-adhesive properties and pronounced antagonistic properties with respect to gram-negative coliform bacteria and gram-positive bacteria and fungus and also resistance to the action of extremal factors. The invention can be carried out in any region of the globe using acting pharmacological and food productions and microbiological and biotechnological laboratories . The production of the probiotic composition is ecologically safe and low waste. The inventive method consists in producing a probiotic composition based on a separated enterococcus strain and having a high antagonistic activity in relation to opportunistic and pathogenic microflora, and used for treatment means and curative food products. The invention, whose feasibility is proved by many clinical and laboratory tests, ensures the high efficiency of the inventive probiotic composition for preventing and curing various skin and mucosa inflammatory processes. The invention is successfully used for cosmetology and dermatology in the form of skin patches, cosmetic masks, medicinal powders, external ointments, and also for gastroenterology in the form of pills and pastilles for stomach, intestines, oral mucosa etc. The inventive method for producing the probiotic composition is universal, reliable and ecologically safe.
Chronic respiratory diseases (CRD) are responsible for more than four million deaths worldwide and have become especially prevalent in developed countries. Although the current therapies help manage daily symptoms and improve patients' quality of life, there is a major need to prevent exacerbations triggered mainly by respiratory infections. Therefore, CRD patients are a prime target for vaccination against infectious agents. In the present manuscript we review the state of the art of available vaccines specifically indicated in patients with CRDs. In addition to pneumococcus, influenza, pertussis, and SARS-CoV-2 vaccines, recently added immunization options like vaccines and monoclonal antibodies against respiratory syncytial virus, are particularly interesting in CRD patients. As new products reach the market, health authorities must be agile in updating immunization recommendations and in the programming of the vaccination of vulnerable populations such as patients with CRDs. Organizational and educational strategies might prove useful to increase vaccine uptake by CRD patients.
BYETTA (exenatide) is a synthetic peptide, glucagon-like peptide-1 (GLP-1) receptor agonist, that was originally identified in the lizard Heloderma suspectum.

Exenatide is a 39-amino acid peptide amide. Exenatide has the empirical formula C184H282N50O60S and molecular weight of 4186.6 Daltons. The amino acid sequence for exenatide is shown below.

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

BYETTA injection is supplied for subcutaneous administration as a sterile, preserved isotonic solution in a glass cartridge that has been assembled in a pen-injector (pen). Each milliliter (mL) contains 250 micrograms (mcg) synthetic exenatide, 2.2 mg metacresol as an antimicrobial preservative, mannitol as a tonicity-adjusting agent, and glacial acetic acid and sodium acetate trihydrate in water for injection as a buffering solution at pH 4.5. Two prefilled pens are available to deliver unit doses of 5 mcg or 10 mcg. Each prefilled pen will deliver 60 doses to provide for 30 days of twice daily administration (BID).
Poor manual ventilation technique is a well-documented problem which occurs irrespective of a provider's qualifications or experience. A disposable safety device, Adult Sotair®, was created to improve manual ventilation delivery among providers. The device is attached to a bag valve mask (i.e. manual resuscitator) and employs a flow limiting valve mechanism to minimize excessive pressure in the airway system without venting air by capping peak flow rates at 55 L/min. For an average adult with normal lung compliance and resistance, this corresponds to a maximum airway pressure of approximately 20 cmH2O which minimizes air entry into the stomach. In this non-inferiority study, a pre-post study design (single group, within-group comparison) to test the non-inferiority of the Adult Sotair® device compared to mechanical ventilation with respect to airway pressure.
Soft tissue sarcoma was rarely seen in pediatric patients, and pediatric Dermatofibrosarcoma Protuberans (PDFSP) was even rare. To our knowledge, the largest report constituted of 19 cases (five of them had no follow-up (FU) status) (1). So we proposed this retrospective study based on the cancer registry of our hospital. Twelve cases who were diagnosed as DFSP before age of 18 were identified. But all of them had been lost of FU for at least two years. So we will try to contact these patients and asked them to be back to our clinic for routine surveillance (history taking and physical exam and optional local image/chest xray) and quality of life (QoL) evaluation after pathological review if this clinical study was approved (2)
Non-alcoholic fatty liver disease (NAFLD), redefined as Metabolic Associated Fatty Liver Disease (MAFLD), is characterized by an extensive multi-organ involvement. MAFLD-induced systemic inflammatory status and peripheral metabolic alteration lead to an impairment of cerebral function. Herein, we investigated a panel of leptin-related inflammatory mediators as predictive biomarkers of neuroinflammation and evaluated the possible role of Bergamot Polyphenolic Fraction (BPF) in counteracting this MAFLD-induced inflammatory cascade. Male DIAMOND mice were randomly assigned to fed chow diet and tap water or high fat diet with sugar water. Starting from week 16, mice were further divided and treated with vehicle or BPF (50 mg/kg/day), via gavage, until week 30. Magnetic resonance imaging was performed at the baseline and at week 30. Correlation and regression analyses were performed to discriminate the altered lipid metabolism in the onset of cerebral alterations. Steatohepatitis led to an increase in leptin levels, resulting in a higher expression of proinflammatory mediators. The inflammatory biomarkers involved in leptin/CCL3-CCL4 axes were correlated with the altered thalamus energetic metabolism and the white matter degeneration. BPF administration restored leptin level, improved glucose and lipid metabolism, and reduced chronic low-grade inflammatory mediators, resulting in a prevention of white matter degeneration, alterations of thalamus metabolism and brain atrophy. The highlighted positive effect of BPF, mediated by the downregulation of the inflammatory biomarkers involved in leptin/CCL3-CCL4 axes, affording novel elements to candidate BPF for the development of a therapeutic strategy aimed at counteracting MAFLD-related brain inflammation.
BACKGROUND AND OBJECTIVES: Genome-wide association studies (GWASs) have identified numerous candidate genes for human brain-imaging phenotypes; however, the biological relevance of many of these genes remains unconfirmed. This study aimed to investigate the causal relationships among tescalcin (TESC) (a GWAS-indicated gene), hippocampal volume, Alzheimer's disease (AD), and the underlying biological mechanisms.
METHODS: Human transcriptional data were analyzed to confirm relative TESC expression in the hippocampus. In cell experiments, RNA-seq analysis was used to identify the potential biological pathways for TESC overexpression, and immunofluorescence imaging and cell viability assays were used to evaluate the effect of TESC overexpression on neuronal structure and survival. In animal experiments, the effects of TESC overexpression on hippocampal volume and cognitive function in normal mice and amyloid-β (Aβ)-induced AD mice were investigated by 9.4 T magnetic resonance imaging and behavioral tests. Underlying mechanisms were further assessed via western blotting and electrophysiological recordings.
RESULTS: Human transcriptional data demonstrated that TESC is primarily expressed in the hippocampus and neurons. TESC overexpression enhanced the viability of HT22 cells and reduced Aβ-induced cell death. In mouse models, Tesc-overexpressing mice revealed increased hippocampal volume, likely owing to enhanced cell viability and long-term potentiation (LTP), and reducing apoptotic- and oxidation-induced hippocampal damage. TESC overexpression could significantly mitigate Aβ-induced hippocampal atrophy and memory impairment, potentially by reducing Aβ-induced neuronal apoptosis and LTP weakening.
CONCLUSION: This study exemplifies the translation of GWAS findings into actionable biological knowledge and suggests that upregulation of TESC may offer a promising therapeutic strategy for AD.
Risk Summary 

Aripiprazole is present in human breast milk. Based on published case reports and pharmacovigilance reports, aripiprazole exposure during pregnancy and/or the postpartum period can lead to variable effects on milk supply in the post-partum period, including clinically relevant decreases in milk supply which may be reversible with discontinuation of the drug. There are also reports of aripiprazole exposure during pregnancy and no maternal milk supply in the post-partum period. Effects on milk supply are likely mediated through decreases in prolactin levels, which have been observed [see Adverse Reactions (6.2)]. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for aripiprazole, and any potential adverse effects on the breastfed infant from aripiprazole, or from the underlying maternal condition.

Clinical Considerations

Monitor infants exposed to aripiprazole through breastmilk for dehydration and lack of appropriate weight gain.
1,218,502. Injectable solutions comprising benzodiazepine derivatives. ARZNEIMITTELWERK DRESDEN VEB. 10 April, 1969, No. 18377/69. Heading A5B. Injectable solutions comprise at least one therapeutically useful benzodiazepine derivative of the general formula: wherein the phenyl nucleus indicated by I can be substituted one or more times by substituents selected from halogen atoms, nitro groups and C 1 -C 4  alkyl and alkoxy radicals, R 1  is H or a C 1 -C 4  alkyl radical, A is a group of the general formula: -N=C-R 2  or | R 3 -N-C=O in which R 2  is an amino, alkyl- | | amino or dialkylamino radical and R 3  is H or a C 1 -C 4  alkyl radical and B is a group of the general formula: in which the phenyl nucleus indicated by II can be substituted one or more times by substituents selected from halogen atoms, nitro groups and C 1 -C 4  alkyl and alkoxy radicals together with a solvent comprising up to 60% w/v of water and at least 40% w/v of a polyethylene glycol which has a molecular weight of between 200 and 600. An additional solvent such as alcohol may also be present.
The invention discloses medicinal and edible traditional Chinese medicine extracted hypoglycemic granules, which are prepared by mixing ginseng, balsam pear, mulberry leaf, Chinese yam, poria cocos, galangal, polygonatum odoratum, corn stigma, medlar, cinnamon and the like, and the preparation process comprises the steps of screening, processing, extracting, granulating, drying, mixing and packaging. The effective components obtained by the original process adopted in the extraction section are one eighth to one fifth of the original medicinal materials, and the prescription compatibility is carried out according to the traditional Chinese medicine theory, so that the effective components can be efficiently and quickly absorbed by human bodies. In addition, the raw materials adopted by the invention are all in the range of national allowable medicine-food homologous catalogues, so that the invention is safe and reliable and conforms to the modern nutritional immunology concept. Although the traditional health care product has certain nutritive value, the effect on removing focus is not obvious in most aspects. The western medicine for reducing blood sugar can be stopped taking after the product is taken for 3-10 days, and the blood sugar index tends to be normal within 1-2 months after the product is continuously taken. The invention has the functions of improving sleep and intestinal tracts while reducing the blood sugar of patients. The balance of various physiological functions of the body can be better maintained from a long-term perspective.
Neuroinflammation has been considered involved in the process of cerebral ischemia-reperfusion injury (CIRI). Transcription factors play a crucial role in regulating gene transcription and the expressions of specific proteins during the progression of various neurological diseases. Evidence showed that transcription factor nuclear factor erythroid 2-related factor 1 (NFE2L1, also known as Nrf1) possessed strong biological activities including antioxidant, anti-inflammatory and neuroprotective properties. However, its role and potential molecular mechanisms in CIRI remain unclear. In our study, we observed a significant elevation of Nrf1 in the cerebral cortex following cerebral ischemia-reperfusion in rats. The Nrf1 downregulation markedly raised COX-2, TNF-α, IL-1β, and IL-6 protein levels during middle cerebral artery occlusion/reperfusion in rats, which led to worsened neurological deficits, higher cerebral infarct volume, and intensified cortical histopathological damage. In subsequent in vitro studies, the expression of Nrf1 protein increased following oxygen-glucose deprivation/reperfusion treatment on neurons. Subsequently, Nrf1 knockdown resulted in a significant upregulation of inflammatory factors, leading to a substantial increase in the cell death rate. Through analyzing the alterations in the expression of inflammatory factors under diverse interventions, it is indicated that Nrf1 possesses the capacity to discern variations in inflammatory factors via specific structural domains. Our findings demonstrate the translocation of the Nrf1 protein from the cytoplasm to the nucleus, thereby modulating the protein expression of IL-6/TNF-α and subsequently reducing the expression of multiple inflammatory factors. This study signifies, for the first time, that during cerebral ischemia-reperfusion, Nrf1 translocases to the nucleus to regulate the protein expression of IL-6/TNF-α, consequently suppressing COX-2 expression and governing cellular inflammation, ultimately upholding cellular homeostasis.
Ultrasound (US) can guide and confirm percutaneous release of the achilles tendon in the clubfoot. However, this technique may not always be available; therefore, surgeons' reported feelings of tendon release ("click" or "pop") and the Thompson sign could demonstrate that they are sensitive and reliable for confirming complete tendon release. The purpose of this study was to compare the reproducibility of clinical maneuvers that aim to detect the reported "click" or "pop" sensation by the surgeon and the Thompson sign after surgical release in percutaneous achilles tenotomy compare with US in patients with clubfoot. A cross-sectional reproducibility study of consecutive patients with idiopathic clubfoot was conducted. All the patients were scheduled to undergo tenotomy in the operating room using the standard percutaneous achilles tenotomy technique under sedation. The surgeon's reported surgical sensation ("click" or "pop") and Thompson signs were compared to the US assessment of the cut. The final Pirani score was used to predict recurrence risk and was correlated with the number of plaster casts and age. Forty-five feet were affected in 30 patients. Eighteen (60%) men. Age range: 1 to 60 months. The sensation of "click" or "pop" was recorded in 38 patients, and complete release was confirmed by US in 37 patients, for a sensitivity (Se) of 0.95 and specificity (Sp) of 0.63. Thompson signs were positive in 33 and 36 patients at 2 evaluations, with Se values of 0.87 and 0.92 and Sp values of 0.88 and 0.75, respectively. The Pirani final score, a predictor of recurrence risk, had an area under the curve of 0.80 (95% CI = 0.63-0.97; P = .005), Se = 0.78, and Sp = 0.56, with a cutoff point of 2.75. The feeling of achilles tendon release and Thompson sign had high sensitivity, prevalence, accuracy, and posttest probability. The confirmation of tendon release based on clinical signs could prevent the use of US.
NEW MATERIAL:A cell obtained by the fusion of mouse myeloma cell and an antibody-producing human cell, capable of producing human antibody, and having strong proliferativity. USE:Preparation of human antibody such as anti-hepatitis B s-antigen antibody (anti-HBs antibody) having prophilactic activity. PREPARATION:For example, leukocyte separated from the peripheral blood of a man positive to anti-HBs antibody is purified e.g. by centrifugal precipitation, mixed with mouse myeloma cell P3-X63, Ag 8, UI, and fused with each other by dripping 45% polyethylene glycol solution to obtain a hybridoma. The hybridoma is diluted with a medium, centrifuged to remove the polyethylene glycol, and cultured in a hypoxanthine-aminopterin-thymidine (HAT) medium to effect the selective growth of the hybridoma and obtain the objective mixed cell. The anti-HBs antibody can be separated from the culture liquid.
Chronic hepatitis B is one of the most widespread viral infections worldwide, potentially leading to liver cirrhosis and hepatocellular carcinoma. Previous studies demonstrated that patients with active viral replication, defined as the presence of detectable serum HBV-DNA or HBeAg, were at increased risk of developing progressive liver disease or death.The prognosis of decompensated cirrhosis resulting from chronic hepatitis B virus infection is poor. Anti-viral therapy in decompensated HBV-related cirrhosis has been recommended by the American Association for the Study of Liver Diseases. However, no high quality research on the effectiveness of anti-viral therapy in decompensated cirrhosis has been performed.

Entecavir is a new nucleotide analogue, which has been proved effective in suppressing viral replication and decreasing the necroinflammatory response, was recommended as a first-line medication in AASLD guideline. Our purpose was to evaluate the effect of Entecavir for patients With decompensated HBV-Related cirrhosis. The main outcomes were liver function, HBV-DNA, disease progression, hepatocellular carcinoma, Child-Pugh score and the survival.
Ablation using CARTO system. Manual collection of RF ablation points by operator or by assistant. Optimal contact force suggested: 10-40g.
The invention relates to the technical field of medical biology, in particular to a building method and application of a novel hepatitis A virus animal model. The preservation number of a hepatitis A virus strain is CGMCC No. 11200, and the complete sequence of the hepatitis A virus strain is as shown in SEQ ID No. 1. The quantified hepatitis A virus strain is inoculated to an experimental animal to produce the animal model, wherein the experimental animal is a marmot and preferably a woodchuck or a Himalayan marmot. The application of the novel hepatitis A virus animal model includes application of the novel hepatitis A virus animal model to researches on hepatitis A viruses or in-vivo infection process and pathogenesis of human hepatitis A viruses and medicine screening or vaccine evaluation.
Subjects will do quiet, sedentary activities for 8 hours. Hourly blood draws and breath sampling will be collected. Bolus C13-Lysine will be given at hour 4.
Tumor metastasis requires systemic remodeling of distant organ microenvironments that impacts immune cell phenotypes, population structure, and intercellular communication. However, our understanding of immune phenotypic dynamics in the metastatic niche remains incomplete. Here, we longitudinally assayed lung immune transcriptional profiles in the polyomavirus middle T antigen (PyMT) and 4T1 metastatic breast cancer models from primary tumorigenesis, through pre-metastatic niche formation, to the final stages of metastatic outgrowth at single-cell resolution. Computational analyses of these data revealed a TLR-NFκB inflammatory program enacted by both peripherally derived and tissue-resident myeloid cells that correlated with pre-metastatic niche formation and mirrored CD14+ "activated" myeloid cells in the primary tumor. Moreover, we observed that primary tumor and metastatic niche natural killer (NK) cells are differentially regulated in mice and human patient samples, with the metastatic niche featuring elevated cytotoxic NK cell proportions. Finally, we identified cell-type-specific dynamic regulation of IGF1 and CCL6 signaling during metastatic progression that represents anti-metastatic immunotherapy candidate pathways.