anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Renal cold ischemia-reperfusion injury (CIRI), a pathological process during kidney transplantation, may result in delayed graft function and negatively impact graft survival and function. There is a lack of an accurate and non-invasive tool for evaluating the degree of CIRI. Multi-parametric MRI has been widely used to detect and evaluate kidney injury. The machine learning algorithms introduced the opportunity to combine biomarkers from different MRI metrics into a single classifier.
OBJECTIVE: To evaluate the performance of multi-parametric magnetic resonance imaging for grading renal injury in a rat model of renal cold ischemia-reperfusion injury using a machine learning approach.
METHODS: Eighty male SD rats were selected to establish a renal cold ischemia -reperfusion model, and all performed multiparametric MRI scans (DWI, IVIM, DKI, BOLD, T1mapping and ASL), followed by pathological analysis. A total of 25 parameters of renal cortex and medulla were analyzed as features. The pathology scores were divided into 3 groups using K-means clustering method. Lasso regression was applied for the initial selecting of features. The optimal features and the best techniques for pathological grading were obtained. Multiple classifiers were used to construct models to evaluate the predictive value for pathology grading.
RESULTS: All rats were categorized into mild, moderate, and severe injury group according the pathologic scores. The 8 features that correlated better with the pathologic classification were medullary and cortical Dp, cortical T2*, cortical Fp, medullary T2*, ∆T1, cortical RBF, medullary T1. The accuracy(0.83, 0.850, 0.81, respectively) and AUC (0.95, 0.93, 0.90, respectively) for pathologic classification of the logistic regression, SVM, and RF are significantly higher than other classifiers. For the logistic model and combining logistic, RF and SVM model of different techniques for pathology grading, the stable and perform are both well. Based on logistic regression, IVIM has the highest AUC (0.93) for pathological grading, followed by BOLD(0.90).
CONCLUSION: The multi-parametric MRI-based machine learning model could be valuable for noninvasive assessment of the degree of renal injury.
BACKGROUND: IgG4-related disease (IgG4-RD) is a rare, systemic immune-mediated fibro-inflammatory condition with an unclear etiology and pathophysiology, potentially affecting multiple organs. It presents with common clinical, radiological, and serological characteristics. This study aims to compare the latest two IgG4-RD classification and diagnostic criteria: Umehara-Okazaki 2011 and ACR/EULAR 2019.
MATERIAL AND METHODS: In a retrospective cross-sectional study conducted across two centers from January 2010 to July 2023, we included patients suspected of having IgG4-RD from various hospital departments. Patients finally diagnosed with other pathologies were excluded. The remaining suspected IgG4-RD cases were evaluated using both Umehara-Okazaki 2011 and ACR/EULAR 2019 criteria.
RESULTS: Out of 34 patients with a clinical diagnosis of IgG4-RD, the Umehara-Okazaki 2011 classified 20 patients: 5 as definitive, 7 as probable, and 8 as possible cases. Applying the ACR/EULAR 2019 criteria to the same cohort resulted in the diagnosis of 9 patients. Notably, retroperitoneal fibrosis and aortitis were the most prevalent form of presentation, accounting for 25% and 22.2% of cases classified under the 2011 and 2019 criteria, respectively.
DISCUSSION: The more recent and stringent ACR/EULAR 2019 criteria focus on histopathology, various forms of presentation, and analytical data, allow for a more accurate classification of patients.
The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine compound for treating gout. The compound comprises the following components in parts by weight: 1 part of glabrous greenbrier rhizome, 1 part of winged euonymus twig, 1 part of Coix Semen Coicis and 1 part of Paniculate Swallowwort Root. The traditional Chinese medicine compound achieves an obvious treatment effect for hyperuricemia and acute gouty arthritis, and has no severe toxic or side effect. Statistics of clinical use results and animal experiment research show that the traditional Chinese medicine compound can obviously relieve pain caused by hyperuricemia and gouty arthritis, can obviously reduce the blood uric acid levels of patients and rats, and has no obvious toxic or side effect. The traditional Chinese medicine compound has the advantages of favorable effect, low price, low side effect and the like, and meets the most simple three basic requirements of patients for a medicine for idealized gout treatment, i.e. for obviously relieving pain of the patients, reducing the side effect on the patients caused by medicine taking and lightening the medicine taking economic burden of the patients.
This is the randomized controlled, multi-centers, and open-labeled study. Delivering systemic chemotherapy between concurrent capecitabine-based long-term radiotherapy and total mesorectal excision (TME) surgery would be more effectively improved local control rates and improved metastases-free survival rates. The investigators attempted to investigate the effect on pathological response of delivering 4 cycles XELOX between concurrent capecitabine-based long-term radiotherapy and TME with lengthening the interval from radiation to surgery. In this study, the participants with high risk of deeper infiltration, or extramural vessel invasion, or circumferential resection margin involvement, or surrounding organs and structures invaded et al. were recruited. The participants will be randomized (1:1 ratio) to a control and intervention arm. The participants in the control arm will receive best current practice of concurrent capecitabine-based long-term radiotherapy followed by TME and then a 6 cycles of XELOX as standard adjuvant chemotherapy. The participants in the intervention arm will receive concurrent capecitabine-based long-term radiotherapy followed by 4 cycles XELOX as neoadjuvant chemotherapy pre- a delayed TME.
BACKGROUND: Induction followed by 1 year maintenance instillation of intravesical Bacillus Calmette-Guerin (BCG) is the standard treatment for intermediate-risk (IR) nonmuscle invasive bladder cancer (NMIBC) patients. Few data exist on the efficacy of Mitomycin C (MMC) instillation in this setting.
METHODS: We retrospectively analyzed 226 IR-NMIBC patients classified by the International Bladder Cancer Group (IBCG) and 250 IR-NMIBC intravescical treatment-naïve patients classified by the European Association of Urology (EAU). All patients received either a full induction course of BCG or 40 mg/40 ml MMC from 2012 to 2022. Optimal treatment was defined as 1-year maintenance for BCG and 11 monthly maintenance instillations for MMC. Kaplan-Meier analysis estimated recurrence-free survival (RFS) before and after inverse probability of treatment-weighting (IPTW) and progression-free survival (PFS). Multivariable Cox regression was used to evaluate difference in recurrence after adjustment for clinically relevant variables before and after IPTW.
RESULTS: Optimal BCG and MMC courses were administered to 21% of IR-IBCG and 23% of IR-EAU patients. At 4-years, patients treated with optimal MMC and BCG treatment had similar RFS and PFS in both EAU and IBCG groups. Patients receiving nonoptimal BCG compared to optimal MMC exhibited lower 4-year RFS after IPTW (82% vs. 68% in EAU and 82% vs. 65% in IBCG). At 4-year optimal MMC had greater PFS non optimal BCG. Optimal MMC treatment predicted recurrence in EAU (adjusted and weighted HR 0.33, 95% CI, 0.11-0.98) and IBCG (adjusted and weighted HR 0.29, 95% CI, 0.08-0.97) groups compared to nonoptimal BCG.
CONCLUSIONS: Optimal 40 mg/40 ml MMC treatment was as effective as optimal BCG in IR-IBCG and IR-EAU NMIBC patients, reducing both recurrence and progression compared to nonoptimal BCG. MMC could be a valid first line alternative to BCG for both IR-EAU and IR-IBCG intravescical treatment-naïve patients, during BCG shortages.
Organ offers from donors with prior or chronic hepatitis C virus (HCV) exposure have been historically underutilized for orthotopic heart transplantation because of the post-transplantation risks \[1, 2\]. The use of HCV antibody-positive (Ab+) donors was associated with attenuated survival benefit after heart transplant and increased coronary allograft vasculopathy in the era before new highly effective direct-acting antiviral agents (DAAs) were developed \[3-5\]. These DAAs target multiple steps in the HCV replication life cycle \[6\]. Newer, well-tolerated, oral direct-acting antivirals (DAAs) have recently been transforming thoracic transplant outcomes after donor-derived HCV transmission. Moreover, now that HCV nucleic-acid testing (NAT), a polymerase chain reaction (PCR)-based approach to detecting viral activity, is widely available and used on all US donor organs, transplant centers have more relevant information about the donor, allowing better risk assessments.

As a result, the utilization of HCV NAT+ donor hearts for transplantation is rapidly gaining momentum, with the obvious benefits of an enlarged donor pool \[7\]. Appropriately, clinical safety trials are currently underway, including a multicenter effort led by the PI of this proposal. Moreover, since the last \~2 years many transplant centers across the nation have started transplanting HCV NAT+ donor organs as standard of care. We estimate that the number of HCV+ cardiac transplants is quickly outpacing the number of trial participants. Hence, it is imperative that safety assessments and risk analyses 'catch up with the real world'.
A data collection system collects and stores physiological data from an ambulatory patient at a high resolution and/or a high data rate (“more detailed data”) and sends a low-resolution and/or downsampled version of the data (“less detailed data”) to a remote server via a wireless network. The server automatically analyzes the less detailed data to detect an anomaly, such as an arrhythmia. A two-tiered analysis scheme is used, where the first tier is more sensitive and less specific than the second tier. If the more sensitive analysis detects or suspects the anomaly, the server signals the data collector to send more detailed data that corresponds to a time period associated with the anomaly. The more specific second tier analyses the more detailed data to verify the anomaly. The server may also store the received data and make it available to a user, such as via a graphical or tabular display.
At the end of cancer treatment (chemotherapy, radiotherapy, or Chemoradiotherapy), a hydrogen water gargle (dissolved for 12 hours or longer) was administered by the investigator or a researcher every Monday through Friday. The changes in six scales described above were tracked in the experimental and control groups on days 1 (T1), 3 (T2), 7 (T3), and 14 (T4) after the end of treatment.
The target is 15 male ja 15 female participants for both the control and intervention groups. To be included, participants need to be with two or more years of resistance training experience, similar to our previous study in females (Hulmi et al. 2017). If more than 15+15 control participants sign up for the study, the final group will be matched to the intervention group based on age, height, weight, and training experience reported on the pre-study questionnaire. The control group maintain their normal nutrition and training during the study.
Patients in the chewing gum and WeChat group are advised to chew one piece of sugarless gum for 20 minutes after drinking each 1 liter PEG. They also receive enhanced instructions via WeChat before two days and one day of colonoscopy to further inform how to chew gum and highlight the importance of adequate bowel preparation.
PURPOSE: Provided is a cosmetic composition which contains micro-spheres of perfluorodecalin capable of effectively inhibiting skin aging, and maintains them without damaging the activity thereof or deteriorating them for a long period of time. The perfluorodecalin easily intrudes into the skin, and well exerts the desired skin care effect. CONSTITUTION: The cosmetic composition comprises micro-spheres of a mixture of 1.0-10.0wt.% of poloxamer 188, 1.0-80.0wt.% of a fluorine compound, and 0.1-5.0wt.% of an emulsion stabilizer. The fluorine compound is selected from perfluorodecalin, and perfluoropolymethylisopropyl ether. The emulsion stabilizer is selected from glycerin, xylitol, and natural polymer compounds. The mixture is processed by a high pressure homogenizer to uniformly diffuse the micro-spheres.
OBJECTIVE: To assess the effectiveness of a kindergarten vision screening program by randomly assigning schools to receive or not receive vision screening, then following up 1.5 years later.
METHODS: Fifty high-needs elementary schools were randomly assigned to participate or not in a vision screening program for children in senior kindergarten (SK; age 5‒6 years). When the children were in Grade 2 (age 6‒7 years), vision screening was conducted at all 50 schools.
RESULTS: Contrary to expectations, screened and non-screened schools did not differ in the prevalence of suspected amblyopia in Grade 2 (8.6% vs. 7.5%, p = 0.10), nor prevalence of other visual problems such as astigmatism (45.1% vs. 47.1%, p = 0.51). There was also no difference between screened and non-screened schools in academic outcomes such as the proportion of children below grade level in reading (33% vs. 29%) or math (44% vs. 38%) (p = 0.86). However, more children were wearing glasses in screened than in non-screened schools (10.2% vs. 7.8%, p = 0.05), and more children reported their glasses as missing or broken (8.3% vs. 4.7%, p = 0.01), suggesting that SK screening had identified successfully those in need of glasses. Examination of individual results revealed that 72% of children diagnosed and treated for amblyopia in SK no longer had amblyopia in Grade 2.
CONCLUSION: The prevalence of amblyopia and other visual problems was not reduced in Grade 2 by our SK vision screening program, perhaps because of poor treatment compliance and high attrition. The results suggest that a single screening intervention is insufficient to reduce visual problems among young children. However, the data from individuals with amblyopia suggest that continuing vision care and access to glasses benefits children, especially children from lower socioeconomic class.
The invention relates to riemerella anatipestifer (RA). The collection number of the RA is CGMCC No.6832. The RA is used for preparing an RA inactivated vaccine. The prepared vaccine can prevent occurrence of infectious serositis of duck characterized by neurological symptom, fibrinous pericarditis, perihepatitis and air sacculitis. The number of RA 6832 in the inactivated vaccine is not less than 1*10<8>CFU/mL. The RA obtained by screening has high pathogenicity. The vaccine prepared from the RA can prevent occurrence of infectious serositis of duck characterized by neurological symptom, fibrinous pericarditis, perihepatitis and air sacculitis, and has good market promotion prospects.
Prospective, randomized study, comparing ticagrelor + aspirin vs. aspirin monotherapy following the 4-week post-procedural combination of Ticagrelor or Plavix with low dose aspirin. The investigators will enroll a minimum of 40 patients. Patients will be enrolled if they have either claudication and/or critical limb ischemia, and angiographically identified superficial femoral artery (SFA) disease requiring intervention, with either total occlusion or a significant SFA stenosis with the presence of Optical Coherence Tomography (OCT) defined clot following stent placement.

Participants will be evaluated at baseline, 1 month, 4 months, 6 and 7 months following SFA intervention. At baseline demographic data will be collected, and anthropomorphic and physiological variables (body mass index, waist circumference, blood pressure). Baseline and 6-month ankle brachial index (ABI) will be performed. A 6-min walk test will be performed at baseline and 6-month follow-up. At 6 month time point patients in both treatment groups will return for a peripheral angiogram and repeat OCT imaging of the SFA segments of interest. Subject will have a final follow up clinic visit at 7 months.
An Internet delivery method delivers electronic information products to a plurality of users via the Internet. A plurality of display formats are stored in a database. The display formats including at least a default display format and a custom display format. Information is also stored for each user indicating whether the user is a specific type of user. When a user logs in, the user is identified as being that specific type of user. If the user is identified as the specific type of user, then an electronic information product is delivered to the user in the custom display format. The electronic information products are accessed via computers connected to the Internet, including wireless devices.
FIELD: microbiology, vaccines. SUBSTANCE: invention relates to preparing the preparation used for prophylaxis and treatment of staphylococcus infections and showing an immunostimulating effect. Staphylococcus cells are cultured for 10 days followed by destruction of cells in an autoclave under 1.0 atm for 30 min. Detoxication is carried out by addition of formalin to staphylococcus suspension for two stages. Firstly, formalin is added up to its concentration 0.3-0.4% in medium and incubated at 37-40 C for 7-10 days and then - up to the final concentration 0.5-0.6% and incubation at 44-46 C for 5-8 days. Destruction of staphylococcus cells can be carried out by gamma-irradiation using  60 Co at the dose 1.0-2.0 x 10 6  R. Then the end product is sorbed on aluminium hydroxide and sterilized in an autoclave. EFFECT: increased storage period and stabilization of the end product. 2 cl, 4 ex
A system and a method for tracking patients having renal disease, particularly Chronic Kidney Disease (CKD), are provided. The system and method track patients through a common system with multiple healthcare professionals, such as doctors, nurses and the like, having access to the system and updating the system based on information regarding the care, treatment, diagnosis, therapy, or the like provided to the patients. The system and method interface with remote machines and supply chains by a modem, via the internet or by wireless devices. The system and method provide a continuum of care for renal patients, i.e., CKD, peritoneal dialysis (PD), home hemodialyis (HHD), in-center hemodialysis and transplant within a single database associated with the system. The system and method track the access information of PD patients and/or HD patients. Specifically, the system and method track access placement, infections, non-infection related problems, medications and hospitalizations. The system and method may track PD and HD information in one comprehensive module.
The invention discloses a formula of a heart-tonifying health-preserving tea bag. At present, the heart-benefiting health-preserving tea bag for conditioning the circulatory system of a human body in the market is not common in formula. In order to overcome the defects of the prior art, the formula of the invention adopts the following technical scheme: 15g of uncaria, 10g of grassleaf sweelflag rhizome, 30g of suberect spatholobus stem, 15g of rehmannia root, 15g of prepared rehmannia root, 10g of asiatic toddalia root, 10g of pilose asiabell root and 10g of astragalus root. Pulverizing into powder, packaging in filter tea bag, putting into cup, and soaking in boiled water for drinking. The main dietotherapy purposes are as follows: has effects in calming liver, tranquilizing mind, invigorating qi, tonifying blood, and promoting health. Compared with the prior formula technology, the invention has the beneficial effects that: has high nutritive value, and can strengthen body constitution, nourish heart.
Participants will be asked to write about different topics regarding their cancer experience. During session 1, participants will be asked to write about the stress of having cancer and their strategies for coping with stressors associated with their cancer (i.e., stress and coping). During session 2, participants will be asked to write about their deepest feelings regarding their cancer experience (i.e., emotional disclosure). During session 3 and the booster session (at 9-month follow-up), participants will be asked to write about positive thoughts and feelings regarding their experience with cancer.
PURPOSE:To obtain a detergent compsn. which is transparent and solid, is uniform in shape, hardness, and easiness to dissolve and disintegrate, gives a cleaned item an elegant hand, foams well even in hard water, and does not generate scum by compounding a specific amphoteric surfactant, an anionic surfactant of a carboxylate type, a nonionic surfactant, and a polyhydric alcohol. CONSTITUTION:This compsn. comprises at least one amphoteric surfactant (A) selected from surfactants of formulas I, II, and III [wherein R1, R2, and R5 are each 7-21C alkyl or alkenyl; R3 and R4 are each lower alkyl; R6 and R7 are each lower alkenyl; A is lower alkylene; M is an alkali or alkaline earth metal or an org. amine; Z is H or (CH2)pCOOY (wherein p is 1-3; and Y is the same as M); and n and m are each 1-3], at least one anionic surfactant of a carboxylate type (B), at least one nonionic surfactant (C), and a polyhydric alcohol (D) in a wt. ratio of A:B:C of (5-20):(40-90):(5-55) and in an amt. of D of 5-35wt.%.
Gastric outlet obstruction (GOO) poses a common and challenging clinical scenario, characterized by mechanical blockage in the pylorus, distal stomach, or duodenum, resulting in symptoms such as nausea, vomiting, abdominal pain, and early satiety. Its diverse etiology encompasses both benign and malignant disorders. The spectrum of current treatment modalities extends from conservative approaches to more invasive interventions, incorporating procedures like surgical gastroenterostomy (SGE), self-expandable metallic stents (SEMSs) placement, and the advanced technique of endoscopic ultrasound-guided gastroenterostomy (EUS-GE). While surgery is favored for longer life expectancy, stents are preferred in malignant gastric outlet stenosis. The novel EUS-GE technique, employing a lumen-apposing self-expandable metal stent (LAMS), combines the immediate efficacy of stents with the enduring benefits of gastroenterostomy. Despite its promising outcomes, EUS-GE is a technically demanding procedure requiring specialized expertise and facilities.
A package for a plurality of identical elongate articles each with a longitudinal axis and a head, center and tail. A pair of film members with abutting parts of their major surfaces are positioned along a common plane and pockets formed in the film members as nonabutting parts across from one another provide a plurality of article receiving spaces. Each article receiving space has a head, center and tail space to position an article with its head, center and tail in the respective spaces when the film members are attached to one another along the abutting parts. The article receiving spaces are disposed within the film members parallel in closely spaced and side by side relation for minimizing the abutting major surfaces between adjacent article receiving spaces and the spaces are in head to tail relation so the axes of the articles received therein are substantially parallel. The film members are thermoformed polymer joined along abutting surfaces. The attached pair of film members have a parting line defining at least one complete package separable from the next adjacent package having an article receiving space.