anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An apparatus senses and records consumption of medical items during performance of a medical procedure. The medical items are enclosed in wrappers having RFID tags in which medical item information is encoded. The apparatus includes a shielded enclosure that attenuates radio frequency signals emanated from RFID tags disposed outside the shielded enclosure to levels that are substantially undetectable within the internal space. RFID antennas inside the shielded enclosure receive radio frequency signals from RFID tags on wrappers that are removed from used items and placed inside the enclosure. An RFID reader decodes the item information encoded in the RFID tags. A medical item inventory module including generates a post-op list of medical items consumed during the medical procedure. Item billing information and usage trend information may be derived from the post-op list. Also, Latex alerts and item expiration alerts may be generated based on information encoded in the RFID tags.
Pyraclostrobin, a typical representative of strobilurin fungicides, is extensively used in agriculture to control fungi and is often detected in water bodies and food. However, the comprehensive toxicological molecular mechanism of pyraclostrobin requires further study. To assess the toxic effects and underlying mechanisms of pyraclostrobin on aquatic organisms, zebrafish embryos were exposed to pyraclostrobin (20, 40, and 60 μg/L) until 96 h post fertilization (hpf). These results indicated that exposure to pyraclostrobin induces morphological alterations, including spinal curvature, shortened body length, and smaller eyes. Furthermore, heart developmental malformations, such as pericardial edema and bradycardia, were observed. This indicated severe cardiotoxicity induced by pyraclostrobin in zebrafish embryos, which was confirmed by the dysregulation of genes related to heart development. Besides, our findings also demonstrated that pyraclostrobin enhanced the contents of reactive oxygen species (ROS) and malondialdehyde (MDA), up-regulated catalase (CAT) activity, but inhibited superoxide dismutase (SOD) activity. Subsequently, the NF-κb signaling pathway was further studied, and the results indicated that the up-regulation of tnf-α, tlr-4, and myd88 activated the NF-κb signaling pathway and up-regulated the relative expression level of pro-inflammatory cytokines, such as cc-chemokine, ifn-γ, and cxcl-clc. Collectively, this study revealed that pyraclostrobin exposure induces developmental toxicity and cardiotoxicity, which may result from a combination of oxidative stress and inflammatory responses. These findings provide a basis for continued evaluation of the effects and ecological risks of pyraclostrobin on the early development of aquatic organisms.
The posterior ankle mobilization treatment is a manual therapy technique that consists of gently gliding your ankle in the backward direction through a pain free range of motion. This is a common therapy technique used by athletic trainers for the treatment of ankle sprains. The objective of this therapy technique is to glide the ankle into the area which restricts range of motion and gently stretch the restricted area. To begin this treatment, a certified athletic trainer with experience in applying this therapy technique will provide mild traction to the ankle joint to lightly distract the bones of the ankle joint. The athletic trainer will then apply two sets of joint mobilizations which will each last 2 minutes. Each repetition will consist of gently gliding the ankle joint in the backward direction until an area of restriction is reached. The athletic trainer will push into the restriction and then glide the ankle back to the starting position.
1. A liposome mitoxantron preparation, containing a liposome carrier and, possibly, pharmaceutically acceptable auxiliary substances. It is characterised in that the liposome carrier is constituted by a mixture of egg lecithin (PC), hydrogenated egg lecitin (HPC) and a resorcinol derivative (RL) in the weight ratio of 1:1:2, or egg lecithin (PC) and a resorcinol derivative (RL) at the weight ratio of 1:1. 5. A method of producing a liposome mitoxantron preparation, containing a liposome carrier and pharmaceutically acceptable auxiliary substances, characterised by the encapsulation degree exceeding 89 percent. It is characterised in that a solution of mitoxantron in an organic solvent is combined with the solution of the lipid carrier components, containing a mixture of egg lecithin (PC), hydrogenated egg lecithin (HPC) and a resorcinol derivative (RL) in the weight ratio of 1:1:2, or a mixture of egg lecithin (PC) with a resorcinol derivative (RL) in the weight ratio of 1:1, in the same or other organic solvent. Solvents are expelled. The lipid layer is distributed in an organic solvent, subjected to cold treatment and lyophilisation. The liophilisate is then contacted with water to obtain the original multilamellar liposome preparation. It is stabilized by subjecting to additional physical processes, to obtain a suspension of calibrated unilamellar liposomes with the size of 100-300 nm, preferably 100-200 nm, and the encapsulation degree exceeding 89 percent. Then, the liposome suspension is lyophilised. 8. An antitumorous pharmaceutical mixture for parenteral administration, comprising a therapeutically effective amount of mitoxantron in the form of a liposome preparation. Unique characteristics: The liposome preparation contains mitoxantron in the weight ration between 1:5 and 1:15 with respect to the lipid components of the liposome carrier. The carrier consists of egg lecithin (PC), hydrogenated egg lecithin (HPC) and a resorcinol derivative (RL) in the weight ratio of 1:1:2, or a mixture of egg lecithin (PC) with a resorcinol derivative (RL) in the weight ratio of 1:1, and it can contain additional pharmaceutically acceptable carriers and/or auxiliary substances.
In obesity, adipose tissue macrophages (ATMs) are abundant immune cells in the adipose tissue and are known as inducers of metabolic inflammation that may lead to insulin resistance and immune disorders associated with obesity. However, much less is known about the ontogeny and physiological functions of ATMs in lean adipose tissue. ATMs are present at birth and actively participate in the synthesis of mediators that induce lipolysis, mitobiogenesis, and thermogenesis in adipocytes. Later in life ATMs limit the thermogenic competence of the adipocytes and favor lipid storage. ATMs respond to lipid overload of adipocytes in obesity with a sequence of pro-inflammatory events, including inflammasome activation and pyroptosis, as well as stimulation of nuclear factor kappa B and interferon regulatory factors that evoke an uncontrolled inflammation. ATMs are life-long constituents of the adipose tissue and hence signals that control ATM development and ATM-adipocyte interactions determine adipose tissue health.
Pulmonary hypertension is a complex and heterogeneous condition with five main subtypes (groups). This review focuses on pulmonary hypertension caused by chronic hypoxia (hypoxic pulmonary hypertension, HPH, group 3). It is based mainly on our own experimental work, especially our collaboration with the group of Professor Herget, whose fifth anniversary of death we commemorate. We have found that oxidation and degradation of the extracellular matrix (ECM) in vitro, in either the presence or the absence of pro-inflammatory cells, activate vascular smooth muscle cell (VSMC) proliferation. Significant changes in the ECM of pulmonary arteries also occurred in vivo in hypoxic rats, namely a decrease in collagen VI and an increase in matrix metalloproteinase 9 (MMP-9) in the tunica media, which may also contribute to the growth activation of VSMCs. The proliferation of VSMCs was also enhanced in their co-culture with macrophages, most likely due to the paracrine production of growth factors in these cells. However, hypoxia itself has a dual effect: on the one hand, it can activate VSMC proliferation and hyperplasia, but on the other hand, it can also induce VSMC hypertrophy and increased expression of contractile markers in these cells. The influence of hypoxia-inducible factors, microRNAs and galectin-3 in the initiation and development of HPH, and the role of cell types other than VSMCs (endothelial cells, adventitial fibroblasts) are also discussed. Keywords: Vasoconstriction, Remodeling, Oxidation, Degradation, Extracellular matrix, Collagen, Proteolytic enzymes, Metalloproteinases, Macrophages, Mast cells, Smooth muscle cells, Endothelial cells, Fibroblasts, Mesenchymal stem cells, Hypoxia-inducible factor, microRNA, Galectins, Hyperplasia, Hypertrophy, Therapy of hypoxic pulmonary hypertension.
PCT No. PCT/AU89/00055 Sec. 371 Date Oct. 9, 1990 Sec. 102(e) Date Oct. 9, 1990 PCT Filed Feb. 10, 1989 PCT Pub. No. WO89/07644 PCT Pub. Date Aug. 24, 1989.A gene sequence including a first promoter for the expression of a major early fowlpox virus (FPV) protein. In a preferred aspect, the gene sequence further includes a second promoter for the expression of a late fowlpox virus protein in opposite orientation to said first promoter. The promoter is useful in developing FPV based vectors for the delivery of vaccine antigens preferably to poultry, and as a tool to study the temporal regulation of poxvirus genes. The invention also offers methods useful in the construction of recombinant fowlpox viruses or related avian poxviruses, which methods are characterized by the introduction of foreign DNA into the fowlpox virus or into virus DNA sequences, which sequences are able to use native FPV promoter regions.
MTX administered orally once weekly with dose ranging from 10 to 20 mg per week through Week 52. Participants also received baricitinib placebo orally once daily. Starting at Week 24, participants who were nonresponders were rescued with baricitinib 4 mg orally once daily and MTX orally once weekly.
PROBLEM TO BE SOLVED: To obtain a specific new phosphonic diester derivative bearing substituted phenyl or substituted nitrogen-contg. heterocyclic group, having hypoglycemic action, therefore useful as e.g. an antidiabetic agent. SOLUTION: This new phosphonic diester derivative is shown by formula I [R<1> is amino, an N-lower alkylamino, N-(substituted) phenylamino or the like; R<2> and R<3> are each H, a lower alkyl, halogen, lower alkoxy, nitro amino or the like; R<4> is H, a lower alkyl or the like; R<5> and R<6> are each a lower alkyl; X, Y and Z are such that all of them are carbon atoms, or one of them is nitrogen atom and the other two are carbon atoms; Q is a single bond or an alkylene] and useful as e.g. an antidiabetic agent. This compound of formula I is obtained by reaction between an amine compound of formula II and an acid chloride of formula III (W is a halogen; Q' is an alkylene) in an inert solvent in the presence of a deacidifying agent.
This was a Phase 2, placebo-controlled, double-blind study in subjects newly diagnosed with head and neck cancer (who had not received previous treatment for oral mucositis) and who were receiving concomitant chemotherapy and radiotherapy. Subject eligibility, including tumor staging, was assessed during the screening period, which was to occur within 30 days prior to the initiation of radiation therapy. The radiation therapy treatment period was approximately 7 weeks, depending on the subject's prescribed radiation plan. Prior to the randomized portion of the trial, the first 7 subjects enrolled in the study entered a safety run-in evaluation and received a total of 2 doses of open-label clazakizumab 160 mg IV, 4 weeks apart (Day 0 and Week 4 of radiation); these subjects were not eligible for the randomized portion of the study. Subsequent to completion of the safety run-in, eligible subjects were randomized 1:1:1 to treatment with 2 doses of clazakizumab 160 mg, or clazakizumab 320 mg, or placebo, administered IV 3 weeks apart (Day 0 and Week 3 of radiation therapy). All subjects were to be followed for 4 weeks post last day of radiotherapy treatment for the primary efficacy and safety assessments and then for up to an additional 12 months of long-term follow-up.
The present invention relates to an essential oil from Pinus koraiensis Siebold and Zucc. nuts and, more specifically, to a composition for protecting nerve cells containing an essential oil of Pinus koraiensis Siebold and Zucc. nuts as an active ingredient. According to the present invention, it is proved that the essential oil of Pinus koraiensis Siebold and Zucc. nuts has antioxidant properties, promotes absorption of glucose, inhibits accumulation and oxidation of neutral lipid, induces expression of peroxisome proliferator activated receptor alpha (PPARα) protein, inhibits accumulation of acidic endoplasmic reticulum, enhances transport of neurotransmitter, and has an excellent neuronal cell protection effect. Accordingly, the essential oil of Pinus koraiensis Siebold and Zucc. nuts has excellent effects in protecting nerve cells, improving cognitive function, and treating neurodegenerative diseases, thereby being used in a variety of ways in the health functional food or pharmaceutical fields.
The intervention group will participate in an exercise program, including aerobic and anaerobic components,twice a week, for 3 months. Exercise testing, blood sampling and cognitive assessment will be performed at the start and in the end of this study.
PURPOSE:To obtain anti-carcinogenic promoter composition useful for preventing cancers by adding to drinks, soups, cosmetics, etc., having high safety, comprising an extract of egg of fowls with an organic solvent. CONSTITUTION:An anti-carcinogenic promoter composition containing an extract obtained by homogenizing the whole egg, vitellus and glair of birds (e.g. chicken, quail or duck) by a homogenizer, respectively, freeze-drying and extracting the homogenized substance with a proper amount of an organic solvent (e.g. methyl alcohol, methyl ethyl ketone or ethyl acetate) as a component. Any extract such as the whole egg powder may be used. Lactose, starch, cornstarch, etc., may be cited as an excipient and an auxiliary useful in production of cancer preventing preparation using the component. Content of the composition in the preparation is preferably >=0.05% (weight/weight) usually.
In summary, SARS-CoV-2 activates the immune system, in which a large number of cytokines, containing IL-6 that can increase vascular permeability and cause migration of fluid and blood cells, is released, causing consequent symptoms such as difficulty breathing and respiratory failure. Also, the common cold or flu replicates itself within infected cells in the body and is released. Excessive amounts of reactive oxygen species are generated due to invasion of pathogens, viruses, vaccines, respiratory infections through viruses, radiation, chemicals, and the like, and the cell membrane lipids of normal cells are destroyed or the protein structure is destroyed, modifying the bases of nucleic acids. Thus, pathogenic microorganisms can cause glomerulitis and vasculitis after vaccination against the COVID-19 virus among citizens in all countries of the world. SARS-CoV-2, in Organs (Figure 1), circulates to organs through blood vessels such as large, medium, and small blood vessels as well as arteries, capillaries, and veins, causing multi-organ diseases. To solve this problem, 8 types of natural herbal medicines can be recombined (earth skin seeds, Phellodendron Amurense Bark, morus bark, schizonepeta stem, Soyeom, Sunui, aerial parts of fringed pink, Plantain Taxa) and decocted for 24 hours to treat the diseases of glomerulonephritis and vasculitis.
BACKGROUND: Liver fibrosis is a predisposing factor for liver cancer. This study will investigate the predictive role of the Triglyceride-glucose and Gamma-glutamyl transferase index (TyG-GGT) as a non-invasive indicator of advanced liver fibrosis in individuals with obesity or overweight.
METHOD: We enrolled patients who underwent metabolic and bariatric surgery as well as intraoperative liver biopsies at Zhejiang provincial people's hospital from August 2020 to March 2023. Clinical characteristics, comorbidities, laboratory data, and pathological variables of patients were collected and analysed. Then, we conducted logistics regression model to compare the performance of the TyG-GGT index with other 4 non-invasive models.
RESULTS: A total of 65 patients were included in this study. 43(66.2%) of them were female, with the mean body mass index (BMI) of 39.0 ± 7.3 kg/m2. Meanwhile, 24(36.9%) patients were diagnosed with diabetes. Advanced liver fibrosis were observed in 16.9% of patients, while liver cirrhosis was found in 4.6% of patients. The multivariable logistics regression showed that TyG-GGT was an independent risk factor of advanced liver fibrosis (OR = 6.989, P = 0.049). Additionally, compared to another 4 non-invasive liver fibrosis models (NFS = 0.66, FIB4 = 0.65, METS-IR = 0.68, APRI = 0.65), TyG-GGT exhibits the highest AUC value of 0.75.
CONCLUSIONS: More than one-third of patients undergoing metabolic and bariatric surgery are afflicted with nonalcoholic steatohepatitis (NASH), and a significant proportion exhibit advanced fibrosis. TyG-GGT was a potentially reliable predictor for screening individuals with overweight or obesity at high risk of advanced liver fibrosis, thus providing clinical guidance for early intervention in this targeted group.
XEN402 0% w/w ointment for topical application. Identical content and appearance to the XPF-002 ointment but without the active medicine. Applied to the skin twice daily for 14 or 21 days.
Bortezomib will be administered at 1.3 mglm2 IVP on Days 1. 4, 8, and 11. Response will be assessed subsequent to each cycle. A total of 8 cycles would beplanned. Patients would be removed subsequent to Cycle 2. if progression of disease is documented.
Baby's development takes its roots in sensorimotricity. Baby coordinates different senses (visual, auditory, tactile, taste, vestibular) to understand the space around him and to implement voluntary motor strategies. These sensory links also allow him to invest hisoral zone and consolidate his oral feeding. Another good sensory integration is necessary for a child to develop harmoniously on motor and psychic levels. In 2018 the study of L. Dagenais revealed a gap in posturomotor development on babies operated on for isolated congenital heart disease. However nobody assess sensory disorders in these babies. With this study the investigators wish to clarify the sensory impact in this situation.
Evoked potentials will be recorded from brain area M1 (motor cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
Patients randomized into the intervention will be assigned a lay health worker who will contact the patient to begin the intervention. The intervention includes: proactive symptom assessments for patients for up to 12-months.
Hepatic fibrosis (HF) is caused by persistent inflammation, which is closely associated with hepatic oxidative stress. Peroxynitrite (ONOO-) is significantly elevated in HF, which would be regarded as a potential biomarker for the diagnosis of HF. Research has shown that ONOO- in the Golgi apparatus can be overproduced in HF, and it can induce hepatocyte injury by triggering Golgi oxidative stress. Meanwhile, the ONOO- inhibitors could effectively relieve HF by inhibiting Golgi ONOO-, but as yet, no Golgi-targetable fluorescent probe available for diagnosis and assessing treatment response of HF through sensing Golgi ONOO-. To this end, we reported a ratiometric fluorescent probe, Golgi-PER, for diagnosis and assessing treatment response of HF through monitoring the Golgi ONOO-. Golgi-PER displayed satisfactory sensitivity, low detection limit, and exceptional selectivity to ONOO-. Combined with excellent biocompatibility and good Golgi-targeting ability, Golgi-PER was further used for ratiometric monitoring the Golgi ONOO- fluctuations and screening of ONOO- inhibitors from polyphenols in living cells. Meanwhile, using Golgi-PER as a probe, the overexpression of Golgi ONOO- in HF and the treatment response of HF to the screened rosmarinic acid were precisely visualized for the first time. Furthermore, the screened RosA has a remarkable therapeutic effect on HF, which may be a new strategy for HF treatment. These results demonstrated the practicability of Golgi-PER for monitoring the occurrence, development, and personalized treatment response of HF.
FIELD: chemical and pharmaceutical industry. SUBSTANCE: tape consists of support and adhesive. The latter is composed of acrylic emulsions, to which is added 25% aqueous solution of ammonia in amounts 1.5 to 5% to achieve pH 6-8.5, viscosity of medium ranging between 10 and 30 thousand mPa.s. Acrylic emulsion is prepared from butyl acrylate and acrylic acid or from acrylic and methacrylic acids and copolymer of acrylic acid ester containing carboxylic groups. EFFECT: increased viability, optimized adhesiveness, and avoided irritation for human skin. 8 cl, 2 ex
PURPOSE:To obtain a composition for hair treatment capable of gradually dyeing white hair into a desired color tone, e.g. black purple to black under mild conditions without exhibiting allergic action and being simple also in dyeing operation. CONSTITUTION:This composition for hair treatment contains a water-soluble extract of a saxifragaceous plant, e.g. Saxifraga stlonifera Meerb. In this case, the water-soluble extract of the saxifragaceous plant is blended in an amount of 0.01-5.0wt.% (expressed in terms of condensed material) based on total amount of the composition. A polyvalent metal salt is preferably added to the composition so as to effectively carry out dyeing of white hair. As such a polyvalent metal salt, ferrous sulfate, ferrous chloride, ferric chloride, ferric acetate, etc., can be exemplified.
Objective: To introduce the progress in research of rash and fever syndrome (RFS) surveillance and early warning both at home and abroad, and provide reference for surveillance and prevention of RFS in China. Methods: The keywords "fever" "rash" and "surveillance" and others were used for a literature retrieval by using China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, PubMed and Web of Science. The languages of literatures were limited in Chinese and English. The key information of the literatures were collected and analyzed with Excel. Results: A total of 36 study papers (21 in Chinese and 15 in English) were included. The studies mainly focused on the pathogen surveillance of RFS (n=19). The pathogens included measles virus, varicella-zoster virus, rubella virus, enterovirus, human B19 virus, dengue virus, streptococcus group A, Salmonella typhi and Salmonella paratyphoid,human herpesvirus, mumps virus and adenovirus. Eight studies were about the surveillance in major events, such as sport game, World Expo and religious gathering, or sudden natural disasters, such as earthquake and tropical storm, during 2010-2015. Eight studies focused on case or epidemic surveillance, most of which were studies from other counties. The surveillance sites were medical institutions. RFS was diagnosed according to the International Classification of Diseases, 9th (ICD-9) and symptoms descripted in chief-complaint. Only one study in Mongolia conducted RFS epidemic prediction. The analysis methods of 36 papers included simple descriptive analysis, time-based early warning models (such as regression analysis, fixed threshold method, Hugh Hart control chart method and cumulative sum control chart method) and time series analysis method. Conclusions: In the future, RFS surveillance system should cover both known pathogens and emerging pathogens. Automatic surveillance using information capture and intelligent modelling can be applied to improve the sensitivity and specificity of RFS surveillance and early warning.