anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Malaria caused by Plasmodium falciparum continues to be a global problem withdevastating consequences. A greater understanding of the immunologic and parasitologic factors associated with infection and disease is badly needed; and will accelerate the development of highly protective vaccines for both mothers and children. Pregnancy malaria is associated with low birth weight, maternal anemia, and gestational hypertension, and both inflammation and the fetal response to infection may contribute to these poor outcomes. Childhood malaria is a major cause of mortality, and we have found that risk of childhood malaria is related to in utero exposure to pregnancy malaria, as well as other host factors like iron status and constitutive cytokine levels. Pregnancy malaria is caused by a distinct parasite binding phenotype, and as our primary hypothesis in this study we speculate that severe childhood malaria parasites may also have distinct features. A longitudinal cohort study will be conducted in Ouelessebougou, Mali, an area of intense seasonal transmission. Up to 2000 pregnant women and their infants and 2000 children ages 0-3 years will be enrolled and followed to age 5 years, with clinical evaluation and periodic venous and peripheral blood samples being obtained. In addition, up to 3000 febrile hospitalized and non-hospitalized children up to age 10 years will be enrolled at the Ouelessebougou district health centers or the Gabriel Tour(SqrRoot)(Copyright) Pediatric Hospital in Bamako, Mali, with acute and convalescent samples being obtained and 500 pregnant women enrolled at the health centers and hospital in Ouelessebougou district or the Gabriel Tour(SqrRoot)(Copyright) Hospital in Bamako for a case-control study on pregnancy malaria and preeclampsia. Up to 1000 children originally enrolled at birth and completed the pregnant women and their newborns study will be re-enrolled and followed-up for up to 10 years as they age from later childhood through adolescence to early adulthood. Clinical, parasitologic and host response (including immunologic) endpoints will be analyzed using appropriate statistical methods, including possible confounders, to determine factors associated with infection and disease in pregnant women and young children.
Adenoid cystic carcinoma (ACC) is an uncommon malignancy that arises in secretory glands. The most common sites for the disease are the major and minor salivary glands but these tumors may also arise in the nasal cavity, lacrimal gland, tracheobronchial tree, breast or vulva. The mainstay of treatment for localized ACC is surgical resection often followed by post-operative radiotherapy. Although this leads to an initially high rate of local control, the 5-year disease-free survival rate is 50-75%. In addition, a significant proportion of the patients develop distant metastases, most frequently in the lung. Compared to other malignancies, ACC tends to grow more slowly. Thus, patients often do well in the short-term but long-term prognosis remains guarded and most succumb to the disease within 10-15 years. To date, systemic therapies have proven to be largely ineffective against recurrent and metastatic ACC. Dovitinib is a broad-targeted-profiled RTK inhibitor active against these three RTKs (VEGF, FGF and PDGF) involved in tumor cell growth. Based on its potency as an inhibitor of these RTKs both in vitro and in vivo, and the compound's oral availability, several clinical trials of dovitinib are underway. This phase II trial will test the hypothesis that dovitinib will be active against this disease. The rationale is based on pre-clinical studies that suggest that dovitinib suppresses tumor growth by blocking constitutive signaling of the fibroblast growth factor receptor-1 (FGFR1) and animal studies in which the drug proved to be active against primary ACC xenografts.
A sensor aggregator is disclosed that may instantiate virtual sensors providing virtual sensor data. Virtual sensor data may be based at least in part on data shared by transitory sensors that come into an environment associated with the aggregator. An aggregator may have local sensors, e.g., non-transitory sensors associated therewith or disposed therein, or mobile sensors operating in conjunction with or for the aggregator, that may be used to provide sensor data to the aggregator that may also be provided as sensor output from the aggregator. An aggregator may combine different sensor inputs to derive virtual sensors based on received sensor data. In an emergency, an aggregator may assist with exit strategies based conditions sensed in various locations to help route people away from problems. Multiple aggregators may share data and trust mechanisms employed to determine if received sensor data may be trusted/used by an aggregator. And, aggregators may operate to store and forward data, such as to a cloud service, on behalf of a sensor. Accounting/payment systems may be used.
Serious infections, including fatal sepsis and pneumonia, have been reported. Some infections were associated with agranulocytosis, neutropenia, or myelosuppression. Discontinue sulfasalazine if a patient develops a serious infection. Closely monitor patients for the development of signs and symptoms of infection during and after treatment with sulfasalazine. For a patient who develops a new infection during treatment with sulfasalazine, perform a prompt and complete diagnostic workup for infection and myelosuppression. Caution should be exercised when considering the use of sulfasalazine in patients with a history of recurring or chronic infections or with underlying conditions or concomitant drugs which may predispose patients to infections.
This is an examiner blind, randomized controlled, parallel designed clinical study that aims to assess the gum health efficacy (antiplaque and antigingivitis) from the combination effect of water flosser and chemistry (0.075% CPC) compared to water flosser and water and to no oral hygiene in a 3-week experimental gingivitis. Thirty participants will be enrolled and allocated into 3 groups: group I - using a water flosser device and water each time; group II - using a water flosser device and dilutable chemistry product (0.075% CPC) after dilution each time (for groups I an II participants will use this regimen treatment twice daily, in the morning and evening, and no other oral hygiene will be allowed during the 21 days of follow-up); group III - negative control in which participants will abstain for any oral hygiene during the 21 days of follow-up. Gingival index measurements will be the primary efficacy variable after using the assigned regimen for 3 weeks for each subject. Subjects will under go baseline, 3 days, 1, 2 and 3 weeks visits. An Analysis of Covariance will be performed on the final or delta plaque scores using the baseline value as covariate. The F-test in this analysis will test the hypothesis that the waterflosser groups are equal in adjusted means.
1413401 Influenza vaccines MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK 24 Sept 1973 [25 Sept1972] 44690/73 Heading A5B [Also in Division C6]  A recombinant, antigenically hybridised virus contains a haemagglutinin antigen having substantially no cross-reactivity with a challenge influenza virus and a neuraminidase antigen having substantial cross-reactivity with the challenge influenza virus, the recombinant being derived from viruses which are non- neurovirulent. The neuraminidase antigen may be derived from a subtype of Type A, B and C influenza viruses or from the Hong Kong variant. The haemagglutinin antigen may be derived from A/equine 1 virus. A recombinant virus H/eq 1/N2 which is effective against the Hong Kong variant can be formulated by recombining an Ao influenza virus e.g. Ao/PR 8/34 (HON 1) with the Hong Kong variant e.g. HK/Aichi/68 (H3N2) to form hybrid recombinants, some of which contain haemagglutinin and neuraminidase antigens which both have cross-reactivity with the type of influenza virus against which the viral vaccine is to be effective. This portion of the population of the first progeny is then recombined, after isolation, with another virus such as A/eq 1/56 (Heq 1  Neq 1 ) with a haemagglutinin antigen having substantially no cross-reactivity with the challenge influenza virus. The vaccine is prepared by adding 500-2000 chick-cell agglutinating units of the recombinant, antigenically hybridised virus to 1 ml or buffered saline, optionally including a mineral oil adjuvant.
FIELD: medicine, microbiology. SUBSTANCE: method involves accumulation of bacteria of genus Lactobacillus in liquid selective nutrient enrichment medium followed by isolation of lactobacilli in solid selective nutrient medium. Method provides preparing selective nutrient enrichment medium for isolation of bacteria Lactobacillus from clinical material in retention their growing properties. Invention can be used for selective isolation of bacteria of genus Lactobacillus from clinical material. EFFECT: simplified method, expanded arsenal of nutrient media. 2 tbl, 1 ex
"Esters of mercapto acyl-carnitines, process for their prepara-tion and pharmaceutical compositions containing same".                Abstract of the disclosures A novel class of esters of mercapto acyl-carnitines is dis-closed, wherein the mercapto acyl radical is the radical of sat-urated mercapto acids having from 2 to 10 carbon atoms. These esters of mercapto acyl-carnitines are prepared e.g. by first preparing the corresponding ester of halogen acyl-carnitine and then substituting therein, by nucleophylic substitution, the -SH group for the halogen atom.    These esters of mercapto acyl-carnitines are useful therapeu-tic agents, e.g. for the treatment of intoxications and burns, and as mucolytic agents.
Juvenile Idiopathic Arthritis (JIA) is one of the common chronic diseases in childhood. Problems such as weakness or pain may occur in JIA, especially in the joints and the muscles around the trunk. These conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with JIA. These conditions may lead to abnormal displacement of the center of gravity, deterioration of biomechanics, and muscle imbalance in children with JIA. All these situations can lead to postural imbalance and asymmetrical loading pattern, which we often encounter in children with JIA. Current studies describing various exercise methods effective on postural alignment. However, no study was found in the literature that searching the effects of these exercise methods on gait parameters in children JIA. Therefore, this study aimed to investigate the effects of two different exercise programs (core based exercise program against neuromuscular training) on gait parameters in children JIA.

In this study, the participants will be evaluated and then they will be divided into two groups randomly. The first group will be administered as a core based exercise program group and the second one will be undergone as a neuromuscular training group. After the interventions, they will be re-evaluted by the physiotherapist and the outcomes will be recorded.
PURPOSE: Depression is a notable contributor to suboptimal outcomes after total joint arthroplasty (TJA). We conducted a systematic review of comparative studies to review the available evidence of interventions that affected depression scores and/or outcomes for patients undergoing TJA.
METHODS: EMBASE, Ovid MEDLINE, PubMed, and Scopus were reviewed systematically from inception until November 15, 2022. Studies that were relevant for this review included comparative studies between patients who received an intervention within 3 months before or after their primary total hip or knee arthroplasty procedure. The interventions included a wide range of modalities, which were grouped into psychotherapy, enhanced perioperative support, and pharmacotherapy. Other interventions included physiotherapy techniques with a psychological focus, art/music-based therapy, occupational therapy support, and educational interventions. Meta-analysis was conducted for psychotherapy and enhanced support.
RESULTS: The final systematic review consisted of 28 relevant studies, most of which were randomized controlled trials. A total of 3,702 patients, with a mean age of 66 years, were considered, of whom 59% were female. Most of the studies reported a notable reduction in depressive symptoms and/or scores based on the interventions being analyzed. At 3 months postoperatively, psychotherapy and enhanced support both resulted in markedly better depression and function scores compared with control subjects, with psychotherapy additionally improving pain scores.
CONCLUSIONS: Overall, a wide range of interventions aimed at psychological optimization of patients undergoing TJA can improve depressive symptoms, pain, and function, even in the absence of a formal diagnosis of depression. Specifically, cognitive-based psychotherapy and enhanced perioperative support had the best evidence. Routine pharmacotherapy plays a limited role, if any, in the care of TJA. Additional efforts to develop pragmatic, evidence-based, and reproducible interventions are warranted to continue to optimize outcomes in TJA patients.
<P>PROBLEM TO BE SOLVED: To provide a safe, inexpensive and easy means for supplementing the deficiency of female hormone (estrogen) in blood in a middle and advanced aged female in a food shape.  <P>SOLUTION: Steamed raw material soybeans are transported to a sterilized chamber, and Rhizopus microsporus var. oligosporus grown in pure culture is added thereto and mixed well. The mixture is inserted into a stainless vat and kept warm at 35°C for 12 h. The resultant product is taken out from an incubator, transferred to a shelf at a room temperature and left there for 24 h. The obtained product is sterilized by putting the product in an oven at 100°C for 1 h after confirming that mycelia have prevailed over the whole. The obtained soybean-fermented product is frozen and preserved. The preserved fermented product is pulverized by adding 75% ethanol in an amount of 1.8 times after thawing, and a supernatant is separated by centrifugal separation. Further a supernatant is separated by the centrifugal separation after adding 50% ethanol in an amount of 1.7 times to the precipitate, and pulverizing the added product. The supernatants obtained by the two-time centrifugal separations are mixed, and heated and concentrated until the content of the solid components becomes 20%. The liquid food having the estrogen activity is obtained by heat-sterilizing the product.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Chest wall pain is a severe and distressing symptom.Interventional pain management aims to use invasive techniques such as joint injections, nerve blocks and/or neurolysis, neuromodulation, and cement augmentation techniques to diagnose and treat pain syndromes unresponsive to conventional medical management. The erector spinae plane block (ESPB) is an interfascial plane block where local anesthetic (LA) is injected between the erector spine muscle and the transverse process. It is a simple procedure, with easy sonographic landmarks, for postoperative analgesia in patients undergoing thoracic, abdominal, lumbar, and urologic surgery. The ESPB was initially described to relieve chronic pain from metastatic disease and rib fractures.

The ESPB provides blockade of ventral and dorsal ramus from T1-2 to T8-12 with easy insertion of a catheter into the distension induced by the injectate. It is performed away from the pleura and neuraxis, with low risk of complications in these structures.To our knowledge it is the first time study to evaluate the effectiveness of tramadol hydrochloride as adjuvant to local anaesthetic in ultrasound guided ESPB in the management of chronic chest wall cancer pain. Our hypothesis is that tramadol, when added to the local anaesthetic solution injected for ESPB, may improve analgesia and decrease the opioid consumption in patients with chronic chest wall cancer pain
For diagnosis purpose, bone marrow sampling is performed for acute myeloid leukemia patients. 2 milliliters of this sample will be collected and analysed for the COSMOS study.
Gut microbiota perturbation and motor dysfunction have been reported in steatosis patients. Rats with mild liver damage (MLD) show motor dysfunction mediated by neuroinflammation and altered GABAergic neurotransmission in the cerebellum. The extracellular vesicles (EV) from mesenchymal stem cells (MSC) have emerged as a promising therapeutic proxy whose molecular basis relies partly upon TGFβ action. This study aimed to assess if MSC-EVs improve motor dysfunction in rats with mild liver damage and analyze underlying mechanisms, including the role of TGFβ, cerebellar neuroinflammation and gut microbiota. MLD in rats was induced by carbon tetrachloride administration and EVs from normal (C-EVs) or TGFβ-siRNA treated MSCs (T-EV) were injected. Motor coordination, locomotor gait, neuroinflammation and TNF-α-activated pathways modulating GABAergic neurotransmission in the cerebellum, microbiota composition in feces and microbial-derived metabolites in plasma were analyzed. C-EVs reduced glial and TNFα-P2X4-BDNF-TrkB pathway activation restoring GABAergic neurotransmission in the cerebellum and improving motor coordination and all the altered gait parameters. T-EVs also improved motor coordination and some gait parameters, but the mechanisms involved differed from those of C-EVs. MLD rats showed increased content of some Bacteroides species in feces, correlating with decreased kynurenine aside from motor alterations. These alterations were all normalized by C-EVs, whereas T-EVs only restored kynurenine levels. Our results support the value of MSC-EVs on improving motor dysfunction in MLD and unveil a possible mechanism by which altered microbiota may contribute to neuroinflammation and motor impairment. Some of the underlying mechanisms are TGFβ-dependent.
The present invention relates to a Chinese medicine dosage form and relates specifically to an Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form. The present invention pulverizes Astragalus membranaceus (Fisch.) Bge. into ultrafine powder, which is subjected to an alcohol-water wetting process to be granulated, extrusion formed under a predetermined rotational speed and then dried. The Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form so manufactured has an increased bioavailability and the dosage form has improved stability and good disintegrability. The Astragalus membranaceus (Fisch.) Bge. wall-breaking dosage form is characterized in that Astragalus membranaceus (Fisch.) Bge. is subjected to wall-breaking pulverization to obtain ultrafine powder that is added with alcohol-water solution to form a soft material and is subjected to extrusion to form wet granules, which are then dried to form the Astragalus membranaceus (Fisch.) Bge. dosage form. The particle sizes of 90% or more of the ultrafine powder are less than or equal to 45 <mu>m.
PCT No. PCT/FR96/01434 Sec. 371 Date Dec. 30, 1997 Sec. 102(e) Date Dec. 30, 1997 PCT Filed Sep. 16, 1996 PCT Pub. No. WO97/12585 PCT Pub. Date Apr. 10, 1997The present invention relates to a composition for the treatment of keratinous material, in particular human hair, comprising, in a cosmetically or dermatologically acceptable medium, at least one grafted silicone polymer, containing a polysiloxane skeleton grafted with non-silicone organic monomers and at least one hydrocarbon which is liquid at room temperature, the hydrocarbon chain of which has from 11 to 26 linear or branched, cyclic or acyclic carbon atoms, as well as its applications. The compositions according to the invention are used in particular as rinse-out products or as leave-in products, in particular for the washing, care and conditioning of the hair, for maintaining the hairstyle or for shaping the hairstyle.
Provided is a composition for improving liver function that is useful for improving, for example, the symptoms of non-alcoholic hepatitis with the use of a resorcinol-type fat or oil derived from a plant.　A resorcinol-type fat or oil derived from a plant is used as an active ingredient of the composition for improving liver function. Preferably, the resorcinol-type fat or oil is an alkyl resorcinol. Also preferably, the resorcinol-type fat or oil is derived from a gramineous plant. Also preferably, the resorcinol-type fat or oil is derived from bran and/or whole grains of wheat and/or rye. This composition for improving liver function is appropriately usable particularly for improving the symptoms of non-alcoholic hepatitis.
The invention provides a nano antibody targeting cadherin 17 and application thereof, wherein the complementarity determining region of the amino acid sequence of the nano antibody targeting cadherin 17 is CDR1 shown in SEQ ID NO. 2, CDR2 shown in SEQ ID NO. 4 and CDR3 shown in SEQ ID NO. 6; or the CDR1 shown in SEQ ID NO. 9, the CDR2 shown in SEQ ID NO. 11 and the CDR3 shown in SEQ ID NO. 13. The cadherin 17-targeted nano antibody has good binding activity with CDH17 protein, has nanomolar affinity with CDH17 protein, has high affinity, and has specific recognition capability on CDH17 protein on the surface of a cell membrane.
Deep breathing for 5 minutes as a baseline Buteyko technique of 2 sets of 8-10 repetitions for 2 days a week. Chest wall mobilization will not be included in Group 2. Repeat the breathing cycle for 5-10 minutes, 2-3 times a day. Total time duration will be 30 minutes.
We aimed to assess the association between SBP-VVV and outcomes in Asian patients with atrial fibrillation (AF). AF patients in the COOL-AF registry with SBP measured at baseline, and at least two other visits were studied. We defined SBP-VVV using the standard deviation (SD) of average SBP. Patients were categorized according to the quartiles of SBP SD. The associations between SBP-VVV and outcomes were assessed in the adjusted Cox model. We studied 3172 patients (mean age 67.7 years; 41.8% female), with the prevalence of hypertension being 69%. Warfarin was used in 69% of patients, whereas 7% received non-vitamin K antagonist oral anticoagulants. The minimum and maximum SD of average SBP in the study population was 0.58 and 56.38 mmHg respectively. The cutoff of SD of average SBP for each quartile in our study were 9.09, 12.15, and 16.21 mmHg. The rates of all-cause mortality, ischemic stroke or systemic embolization (SSE), major bleeding, and intracranial hemorrhage (ICH) were 3.10, 1.42, 2.09, and 0.64 per 100 person-years, respectively. Compared with the first quartile, patients in the fourth quartile had a significantly higher risk of mortality (adjusted HR 1.60, 95%CI 1.13-2.25), bleeding (aHR 1.92, 95%CI 1.25-2.96) and ICH (aHR 3.51, 95%CI 1.40-8.76). The risk of SSE was not significantly different among the quartiles. SBP-VVV had a significant impact on the long-term outcomes of Asian patients with AF, particularly mortality and bleeding. Adequate SBP control and maintaining SBP stability over time may improve outcomes for AF patients.
PURPOSE:To obtain an anti-inflammatory which has excellent anti-inflammatory action, can be given orally or parenterally with durative effect and high stability to heat, light and air, by using dihydromyricetin as an active ingredient. CONSTITUTION:The subject preparation contains dihydromyricetin as an active ingredient. The substance is mixed with an excipient, a binder, a disintegrator, a lubricant and other additives and prepared into tablets, granules or powder in a usual manner. Dihydromyricetin has a chemical formula of C15H12O8, and is also called ampelopsin or 3,5,7,3',4',5'-hexahydroxyflavanone. The compound is rich in safety, soluble in water and alcohol and has actions to inhibit tyrosinase, prevent ultraviolet rays, and resist to oxidation, thereby it is used as a cosmetic. The dihydromyricetin may be synthesized or a natural product obtained by extraction of plants such as willow trees.