anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of this project is to demonstrate that ADIPOKINES, as well as the PPAR alpha and gamma are implied in the intensity of the steatosis and in the regulation of the inflammatory process and the hepatic fibrogenesis in alcoholic liver disease. In order to prove this hypothesis, we will study among patients having a ALD at various stages of histological severity: 1) the hepatic and subcutaneous abdominal adipose tissue expression of the PPAR alpha and PPAR gamma, 2) the hepatic and subcutaneous abdominal adipose tissue expression of the TNF alpha, the IL1Ra, the IL6 and the IL10, 3) the hepatic and subcutaneous abdominal adipose tissue expression of the ADIPOKINES (leptin, adiponectin, resistin), 4) the serum ADIPOKINES values, the cyanotic of the mRNA expression and of the serum ADIPOKINES values after 7 days of alcohol withdrawal 50 patients will be studied (25 having ALD without cirrhosis, with or without acute alcoholic hepatitis (AAH) and 25 having alcoholic cirrhosis with or without AAH). A part of liver biopsy will be frozen in a dry tube. The percutaneous adipose tissue will be obtained with a punction on the abdominal level at the time of inclusion of the patients having AAH and, for the second time, after 7 days of alcohol withdrawal, than will be frozen. The TNF alpha, the IL1Ra, the IL6, the IL10, the leptin, the adiponectin and the resistin expression as well as the hepatic and adipose tissue PPAR alpha and gamma will be evaluated by PCR in real time. The serum concentration of the ADIPOKINES (leptin, adiponectin, resistin) will be measured by ELISA or RIA.

If our hypothesis is true, severity of liver lesions (steatosis, AAH, fibrosis) could be positively correlated with the expression in the liver and the adipose tissue and / or the serum values of the anti-inflammatory cytokines and ADIPOKINES (TNF alpha, IL6, leptin, resistin) and negatively with the cytokines and ADIPOKINES which are potentially anti-inflammatory (IL1Ra, IL10, adiponectin). We also expect to find a negative correlation between the amount of hepatic and adipose tissue PPAR-alpha and PPAR-gamma mRNA and the severity of the liver disease.
Patients suffering from sepsis-induced acute lung injury (ALI) exhibit a high mortality rate, and their prognosis is closely associated with infiltration of neutrophils into the lungs. In this study, we found a significant elevation of CD64+ neutrophils, which highly expressed p75 neurotrophin receptor (p75NTR) in peripheral blood of mice and patients with sepsis-induced ALI. p75NTR+CD64+ neutrophils were also abundantly expressed in the lung of ALI mice induced by lipopolysaccharide. Conditional knock-out of the myeloid lineage's p75NTR gene improved the survival rates, attenuated lung tissue inflammation, reduced neutrophil infiltration and enhanced the phagocytic functions of CD64+ neutrophils. In vitro, p75NTR+CD64+ neutrophils exhibited an upregulation and compromised phagocytic activity in blood samples of ALI patients. Blocking p75NTR activity by soluble p75NTR extracellular domain peptide (p75ECD-Fc) boosted CD64+ neutrophils phagocytic activity and reduced inflammatory cytokine production via regulation of the NF-κB activity. The findings strongly indicate that p75NTR+CD64+ neutrophils are a novel pathogenic neutrophil subpopulation promoting sepsis-induced ALI.
Post-traumatic Stress Disorder (PTSD) is a prevalent and pervasive mental disorder. Studies have shown that there is a significant reluctance to use mental health services by trauma-exposed individuals at high risk for developing PTSD. Providing clinical services in combat or disaster zone might be difficult. Trauma-focused cognitive behavioral therapy (CBT) effectively reduces the prevalence of PTSD among recent survivors. Telephone based CBT was found to be effective in mood and anxiety disorders, but has not been tried in PTSD. Establishing the effectiveness of telephone based CBT has significant service delivery and public health implications. Preventing PTSD significantly reduces individuals' suffering and disability We will screen, by telephone, up to 1200 survivors of traumatic events, from a general hospital emergency department trauma registry list, randomize the first 240 with ASD or Acute PTSD to either early, telephone based cognitive behavioral therapy (ET_CBT) (n=120) or a no-treatment control condition (n=120). We will provide five sessions of ET-CBT to the former and compare the two groups three and eight months later.

Survivors from both groups who will continue to have PTSD at three months (after either treatment or waiting list), will receive 12 sessions of face-to-face, trauma focused CBT. A first phase of the study will consist of establishing the acceptance of ET-CBT and its main components (e.g., exposure to traumatic reminders) by survivors, and optimizing the protocol. It will involve 20 survivors and no randomization. Subsequent to that phase we will start recruiting for the main study. The study's main hypothesis is that early CBT will reduce the prevalence of PTSD three and eight months after the traumatic event.
An envelope split-full-split thickness flap without vertical incisions will be carried out in the gingival recession area. Afterwards, a xenogenic collagen matrix (XCM) will be applied to all teeth with recession defect. The XCM will be cut into the right dimensions, measured with the probe, and its measurements recorded; then it will be placed from the CEJ to the bone crest on the recipient bed using single sutures, 7/0 PGA sutures. The matrix will be rehydrated with blood, in order to reconstitute and maintain the maximal thickness possible. The flap will be closed slightly coronal to the CEJ with a sling suture using resorbable PGA 6/0 sutures and avoiding any compression of the matrix.
The intervention group will participate in multicomponent intervention conducted by and expert psychologist that target different aspects of the caregiving experience (affective responses, communication skills, burden experience, social support and loneliness, cognitive performance, the practice of mindfulness and health-related behaviours). The number of sessions will be 8, 1 session of 90 minutes a week, and the number of participants will be 12-14 per group. In some sessions other collaborators will be invited to participate (social workers, physiotherapist).
Each day in the morning, for lunch, or in the afternoon, participants will drink one 12 fl oz. can of Poppi ACV prebiotic soda.
The clinical association of purpura, arthralgia, and arthritis was first described in 1837 in a publication by Johann Lukas Schönlein, a German physician. In 1874, Eduard Henoch, a student of Schönlein, reported cases of children with purpura, abdominal pain, bloody diarrhea, and joint pain. IgA vasculitis, or Henoch-Schönlein purpura, is a systemic hypersensitivity vasculitis caused by the deposition of immune complexes in small blood vessels, including the renal glomeruli and mesangium. In the skin, the presentation is with non-thrombocytopenic purpura or urticaria. Worldwide, IgA nephropathy is the most common cause of primary glomerulonephritis. Detection of IgA deposition in small blood vessels and the renal glomeruli is diagnostic in most cases. This article aims to review the history, current classification, epidemiology, presentation, and diagnosis of IgA vasculitis and nephropathy, disease associations or trigger factors, including infections, vaccines, and therapeutic agents, and highlights some future approaches to improve diagnosis and clinical management.
PURPOSE:To obtain a deodorizing agent containing extract from one or more kinds of plants selected from Plantago major L. var. asiatica or plant analogous thereto as an active ingredient, having high mouth odor-deodorizing force and excellent safety to human body and effective for oral cavity, household use and industry. CONSTITUTION:The aimed agent containing at least either one position or extract thereof among ground parts, root parts or seeds of at least one or more kinds of plants selected from (Plantago major L. var. asiatica) or analog plants thereof as an active ingredient. When the agent is used, the agent is prepared in a form of solution, paste, powder, etc. The above-mentioned effective ingredient is used at an amount of 0.001-50%, especially preferably 0.001-10% based on total deodorizing agent. Furthermore, Plantago major L., Plantago depressa willd, Plantago lanceoatalinn, etc., is extracted using a solvent (water, methanol, n-hexane, etc.) and used as an active ingredient.
The invention discloses a compound gardenia oil soft capsule and a method for preparing the same. The gardenia oil soft capsule is used for treating insomnia and consists of a content and rubber sheetThe invention discloses a compound gardenia oil soft capsule and a method for preparing the same. The gardenia oil soft capsule is used for treating insomnia and consists of a content and rubber sheet, wherein the content consists of clear spina date seed oil, clear semen boitae oil and clear gardenia oil according to a mass ratio of 3:2-3:1-1.5, and the rubber sheet consists of a rubber material,, wherein the content consists of clear spina date seed oil, clear semen boitae oil and clear gardenia oil according to a mass ratio of 3:2-3:1-1.5, and the rubber sheet consists of a rubber material, humectant, water and antiseptic according to a mass ratio of 10:4-6:7-14:0.005. The clear spina date seed oil, the clear semen boitae oil and the clear gardenia oil are mixed uniformly to form the cohumectant, water and antiseptic according to a mass ratio of 10:4-6:7-14:0.005. The clear spina date seed oil, the clear semen boitae oil and the clear gardenia oil are mixed uniformly to form the co ntent; the water is heated and added sequentially with the humectant, the antiseptic and the rubber material to form a gum-solution; the content and the gum-solution are pressed by the prior pressing ntent; the water is heated and added sequentially with the humectant, the antiseptic and the rubber material to form a gum-solution; the content and the gum-solution are pressed by the prior pressing method so as to be formed; and after post treatment, the compound gardenia oil soft capsule is obtained. The compound gardenia oil soft capsule is reasonable in formula, has a sedative-hypnotic functimethod so as to be formed; and after post treatment, the compound gardenia oil soft capsule is obtained. The compound gardenia oil soft capsule is reasonable in formula, has a sedative-hypnotic function which can be enhanced by long drug application time, is free from tolerance and suitable to be used for treating insomnia, and can relieve physical fatigue.                                         on which can be enhanced by long drug application time, is free from tolerance and suitable to be used for treating insomnia, and can relieve physical fatigue.
INTRODUCTION: Hoffa fractures are a rare and often overlooked entity. The main goal of surgical treatment is to restore the articular surface and maintain knee function. However, current clinical data indicate heterogeneous outcomes. The aim of this multicenter study was to obtain a representative data set of patients with isolated Hoffa fractures with special emphasis on concomitant soft tissue injuries, diagnostic algorithms, treatment strategies and functional outcomes.
MATERIALS AND METHODS: Participating Level I trauma centres were asked to review their internal database for isolated Hoffa fractures treated surgically between 2010 and 2020. Demographics, mechanism of injury, diagnostic and therapeutic algorithm, Letenneur classification, concomitant soft tissue injuries, and postoperative knee function and complications were analysed.
RESULTS: A total of 56 patients from six participating trauma centres were included. The median age at injury was 45 years (15-94) with a median follow-up of 19 months (2-108). The most common mechanism of injury was high-energy trauma, with unicondylar lateral Letenneur type I and II fractures being the most common. Surgical treatment was independent of the type of fracture and included isolated screw fixation, combined plate and screw fixation and isolated plate osteosynthesis. Isolated screw fixation resulted in significantly better range of motion (ROM) values (p = 0.032), but the highest number of postoperative complications (n = 14/20, n.s.) compared to the other fixation techniques. The highest number of fixation failures requiring revision was observed in the plate and screw fixation group (n = 3/8, p = 0.008). Osteochondral flake fractures (n = 12/43, 27%) and lateral meniscus injuries (n = 5/49, 10%) were commonly seen in Hoffa fractures.
CONCLUSIONS: Treatment of Hoffa fractures with screw fixation resulted in significantly better functional outcomes, probably due to less comminuted fractures. Concomitant cartilage, meniscal and ligamentous injuries are common and warrant preoperative recognition and management.
Each area will be treated with a dose contained in a vial of Sculptra®. For conducting the study, six vials of the product will be available per subject, and one vial will be used in each session with up to maximum a total volume of 16mL per treated area. It will be 3 session with interval of 1 month in total.
In the ivabradine study, randomization will be implemented with 1:1:1:1 allocation among the combinations of ivabradine/placebo and coordinated/usual care. All participants receive either ivabradine or placebo for 3 months (12 weeks) with a follow-up period for an additional 3 months (total study duration of 6 months). See NCT06305806 for additional details.
Optimal fluid management has been considered as crucial part to determine postoperative outcome and organ function. Many reports have focussed on evaluation of fluid responsiveness using various parameters such as pulse pressure variation (PPV) or stroke volume variation (SSV) derived from invasive or semi-invasive monitoring. Recently developed, non invasive cardiac output measurement(NICOM, Cheetah Medical, Portland, OR)has enabled continuous cardiac output(CO) monitoring just by attaching electrode on thorax. Moreover, CO and SSV derived from NICOM have been demonstrated as predictors of fluid responsiveness. Therefore, the aim of this study is to evaluate stroke volume variation derived from NICOM as a predictor of fluid responsiveness in neurosurgical patients. In addition, we plan to reveal inconclusive patients using gray zone approach.
INTRODUCTION AND AIMS: Capsule endoscopy is part of the diagnostic approach to patients with suspected small bowel bleeding and data on its clinical impact are still limited in developing countries. The primary aim of the present study was to determine its impact on subsequent diagnostic and therapeutic decisions.
MATERIAL AND METHODS: A retrospective study was conducted that included all the patients that underwent capsule endoscopy with the PillCam™ SB 3 Capsule system due to suspected small bowel bleeding treated at the Hospital Universitario Fundación Valle del Lili between January 2011 and December 2020.
RESULTS: A total of 158 patients met the inclusion criteria. Mean patient age was 63 years (interquartile range [IQR], 52-74), 53.6% of the patients were women, and high blood pressure was the most frequent comorbidity (43.7%). The main indication was overt bleeding (58.2%). Of all the capsule endoscopies carried out, 63.9% showed lesions that were potentially responsible for bleeding. Medical or surgical treatment was indicated in 63.3% of the case total. Rebleeding at 6 months occurred in 15 patients and there were 2 deaths due to gastrointestinal bleeding at 6 months.
CONCLUSIONS: Capsule endoscopy has a high impact on patients with suspected small bowel bleeding, with respect to clinical decision-making, as well as rebleeding, hospitalization, and mortality outcomes. The positivity rate of lesions potentially responsible for bleeding was similar to that reported in developed countries.
Metabolic dysfunction-associated steatotic liver disease (MASLD), with its steadily increasing prevalence, represents now a major problem in public health. A proper referral could benefit from tools allowing more precise risk stratification. To this end, in recent decades, several genetic variants that may help predict and refine the risk of development and progression of MASLD have been investigated. In this review, we aim to discuss the role genetics in MASLD plays in everyday clinical practice. We performed a comprehensive literature search of PubMed for relevant publications. Available evidence highlights the emergence of genetic-based noninvasive algorithms for diagnosing fatty liver, metabolic dysfunction-associated steatohepatitis, fibrosis progression and occurrence of liver-related outcomes including hepatocellular carcinoma. Nevertheless, their accuracy is not optimal and application in everyday clinical practice remains challenging. Furthermore, susceptible genetic markers have recently become subjects of great scientific interest as therapeutic targets in precision medicine. In conclusion, decisional algorithms based on genetic testing in MASLD to facilitate the clinician decisions on management and treatment are under growing investigation and could benefit from artificial intelligence methodology.
A digital pillbox, a personal alert device, and a computer-implemented system and method for aiding a patient in maintaining a desirable dosage schedule of medicines. Sensors and logic determine a time and quantity of a dosage taken, if any, and the system keeps records and monitors against a schedule and against a dynamic, learning, behavioral model of the patient. The schedule is remotely updateable by e.g. the patient's pharmacist. The system is equipped to alert e.g. a friend of the patient, or emergency services, if the patient fails to take the desired medications or if the patient's dosage behavior exhibits a significant change.
When the processing of medical images is divided among multiple workers, the invention enables easy verification of the work status of each worker. The server is provided with an image storage unit, an image-processing unit, a progress management unit and a UI control unit. The image storage unit stores medical images of different regions of a subject's body. The image-processing unit receives a request from one of a plurality of clients for each medical image and processes said medical image. The progress management unit generates processing progress information for each medical image on the basis of the stage of processing by the image-processing unit for each of the multiple medical images and manages the progress information for the multiple medical images collectively. According to the processing stages indicated in the progress information, the UI control unit generates display screen data to show the processing status of the medical images of the corresponding body regions in the multiple screen regions corresponding to the multiple body regions and transmits same to one of the multiple clients.
In the prepn., (a) a dil. aq. soln. of the mucoprotide components is produced by autolysis of the starting material, precipitating precipitable proteins with dilute lead acetate and dilute ammonium sulphate, and sepn. of the supernatant; (b) the aq. soln. is treated with acetone to form 3 layers; (c) the upper and middle layers are sepd. from the lower layer; (d) the two upper layers from (c) are heated to ppte unstable and antigenic substances; and (e) the ppte is sepd. off and discarded. A new mucoprotide prod. is produced from liver parenchyma, placenta, yeast or other natural sources and chiefly consists of protides such as protein and protein hydrolysates with a ca. 0.1-40% mucoid content. The mucoprotide shows a marked saddle in the IR spectrum at a wave number between ca. 1000 and 1200. T'e mucoprotide product is useful for the treatment of Allergies and hypersensitivities, toxic states, undesired side-effects of drugs, drug-dependence and alcoholism. It is particularly useful when the disorder to be treated is accompanied or caused by damaged liver function. The product may be administered orally or parenterally.
A monitoring system incorporates, and method and computer program product provide a contextual gaze detection based user selection for prompting caregiver actions by a person with ambulatory and communication deficits or limitations. A controller of the monitoring system receives receiving at least one image stream from a camera system comprising at least one image capturing device. The camera system captures a first image stream that encompasses eyes of a person and a second image stream that at least partially encompasses surrounding object(s) and surface(s) viewable by the person. The controller determines an eye gaze direction of the person and a region of interest (ROI) aligned with the eye gaze direction. The controller identifies an object and associated caregiver action contained within the ROI. The controller communicates a notification to an output device, which presents to a second person, an indication of interest by the person in the caregiver action.
PURPOSE: This study aimed to investigate the safety and feasibility of a novel stent-assisted ileal bypass for rectal cancer patients who received sphincter-preserving surgery.
METHODS: Patients who were diagnosed with rectal cancer and received sphincter-preserving surgery plus a novel stent-assisted ileal bypass were respectively included from January 2022 to January 2023. Biofragmentable ileal stent with diaphragm sheet in the cavity was placed in the terminal ileum using absorbable sutures after anastomosis. At the proximal end of the stent, an intestinal diversion tube was placed in the prefabricated purse-string, through which faeces were drained. The stent completely disintegrated in the body after 3-4 weeks, which protected the anastomosis after surgery and avoided protective stoma. Clinical characteristics and surgical outcomes were collected.
RESULTS: Eleven patients who successfully received surgery were included. There were seven (63.6%) males and four (36.4%) females. The tumour size was 3.2 ± 1.7 cm and the lower verge of tumour to anal verge was 6.8 ± 1.3 cm. As for surgical outcomes, operation time was 216.4 ± 54.1 min, blood loss was 43.6 ± 64.6 mL, time to first flatus via intestinal diversion tube was 3.2 ± 1.1 days, time to discharge stent was 22.8 ± 3.0 days, and postoperative hospital stay was 21.0 ± 5.4 days. Two patients suffered from postoperative complications including pneumonia and incision infection.
CONCLUSION: This novel stent-assisted ileal bypass is safe and feasible, it provides a new choice for rectal cancer patients to avoid protective stoma and secondary surgery.