anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to compounds of the following formula ##STR1## in which Y is sulfur, S(O), or S(O) 2  ; R stands for C 1  -C 3  alkyl, or can form a C 3  -C 8  carbocyclic ring. Q is a C 1  -C 8  hydrocarbylene diradical; and derivatives thereof. The compounds can be made by reacting a 20(S)-formyl vitamin D derivative with tert-butyl hypochlorite to form the corresponding acid chloride which is then reacted with potassium O-ethyl dithiocarbonate followed by photochemical reaction and decarbonylation, treatment with aminoethanol, and conversion to the 22-thiol. The 22-thiol is then alkylated to form the desired sidechain. The compounds show antiinflammatory and immunomodulating effects. They also exhibit strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
Intervention: Households in the 'Small-voucher' arm receive a voucher (\~$12-17) every month that entitles them to purchase fresh foods (fruits, vegetables and animal sourced foods). The households in this arm also receive the same social behavioural change communication (SBCC) messages as the 'BCC-only' arm.
In Part 2, we will recruit 60 ICs of patients with GBM who will be randomized to receive either MCP-C or EUC. MCP-C will be delivered individually over 7 1-hour-long sessions within 7 - 14 weeks.
Hypertensive disorders are one of the common disorders in pregnancy that cause complications in the mother and the fetus. Preeclampsia, one of the hypertensive disorders of pregnancy, is defined as the presence of hypertension, proteinuria or organ damage that occurs after the 20th week of pregnancy. Preeclampsia affects 5% to 7% of all pregnancies. It causes more than 70,000 maternal deaths and 500,000 fetal deaths worldwide each year. Preeclampsia is among the main causes of maternal mortality and morbidity. Preeclampsia is the first cause of maternal death due to hypertension. According to the report on causes of maternal death in our country, 14.2% of pregnant women died due to hypertensive diseases in 2019. Pregnancy-induced hypertension is the second leading cause of maternal deaths. Preeclampsia causes increased blood pressure in pregnant women, cardiovascular diseases, cerebrovascular accidents, and dysfunction in organs such as the liver, kidney and uterus. In addition to affecting the systems, it is also a condition that causes anxiety and fatigue in pregnant women. The most effective treatment for preeclampsia is delivery. In hospital, treatment includes MgSO4 therapy, blood pressure monitoring, urine monitoring, a high-protein and salt-restricted diet, and control of fetal movements and midwifery care to keep blood pressure at normal levels and prevent eclampsia. In addition to medical treatment in preeclampsia, complementary treatments such as music therapy, acupuncture and massage are also used. Massage application helps relax the muscles. It is stated that massage applied to pregnant women positively affects anxiety, blood pressure and fatigue. Equipment such as tennis ball, golf ball and massage ball are used for muscle relaxation. It is thought that massage ball application, one of the methods used in massage, will reduce anxiety, fatigue and be effective in lowering blood pressure.
Neuroendocrine tumors (NETs) are rare neoplasms arising from the diffuse endocrine system and spreading throughout the different organs and tissues of the body. Tumor-induced osteomalacia (TIO), is a rare, serious paraneoplastic syndrome primarily derived from a benign tumor of mesenchymal tissue. NETs and mesenchymal tumors are often insidious and are undetectable by conventional imaging techniques including ultrasound, computed tomography and magnetic resonance, while a permanent cure will rely on exact localization and completely removal of the tumor.

Positron emission tomography (PET) provides a valuable tool for the diagnosis and differential diagnosis, staging, efficacy evaluation and recurrence monitoring of various tumors. NETs and mesenchymal tumors overexpress somatostatin receptors (SSTRs), so molecular imaging using radiolabeled somatostatin analogues may be one of the best ways to detect the occult tumors. Recently, somatostatin analogue labelled with gallium-68 (68Ga-DOTA-TATE) as a novel positron tracer has shown to be effective for the detection of NETs and mesenchymal tumors. In this prospective study, the investigators will use the most advanced imaging equipment, integrated PET/MR，and PET / CT with specific imaging agent 68Ga-DOTA-TATE and conventional imaging agent \[F-18\] fluorodeoxyglucose to image patients. For patients suspected of or diagnosed with NETs and TIO, the investigators aim to evaluate the roles of integrated PET/MR and PET/CT in differential diagnosis, detecting primary and metastatic lesions, guilding biopsy, staging and determining treatment plan prior to treatment; for patients with a history of NETs and TIO, the aim is to evaluate the value of integrated PET/MR and PET/CT for treatment response assessment, detection of recurrences and metastatic lesions; for patients with inoperable and metastatic NETs, the aim is to find the value of integrated PET/MR and PET/CT in assessing the expression level of SSTRs to guide peptide receptor radionuclide therapy.
PURPOSE: This study aims to compare the mid-term radiographic, clinical results and survivorship between distal tibial tuberosity high tibial osteotomy (DTT-HTO) and conventional biplanar medial open-wedge high tibial osteotomy (cOW-HTO).
METHODS: The weight-bearing line ratio (WBL%) and medial proximal tibial angle (MPTA) were evaluated using a standing anteroposterior view of lower extremity. The posterior tibial slope (PTS), Caton-Deschamps index (CDI), tilting angle (TT) and lateral shift ratio (LSR) were evaluated using the lateral views and Merchant views. The Knee Society (KS) knee and function score, Lysholm score, and Anterior Knee Pain Scale (Kujala score) were were used to evaluate the functional outcomes. All parameters were evaluated preoperatively and at the final follow-up. The postoperative complications and survivorship for both groups were also evaluated during the follow-up period.
RESULTS: The WBL% and MPTA exhibited no significant differences between the two groups preoperatively and at the final follow-up. The postoperative CDI and TT in the cOW group decreased significantly compared with the DTT group (p = .037 and .041, respectively). The PF grade showed a significant increase after DTT-HTO and cOW-HTO (p = .036 and <0.001, respectively). Furthermore, the postoperative PF grade of cOW group was significantly higher than that of DTT group (p = .039). The KS knee and function score, Lysholm score, and Kujala score for both groups improved similarly at the final follow-up. The survivorship free of revision was 92.7 % in the DTT group and 94.2% in the OW group.
CONCLUSIONS: Despite observing a lower risk of PF joint progression in DTT-HTO compared to cOW-HTO, the clinical outcomes and survivorship after DTT-HTO and cOWHTO were comparable over a mid-term follow-up.
This systematic review and meta-analysis aimed to determine whether apical patency increases postoperative pain after endodontic therapy. This study explored the degree and incidence of postoperative pain during root canal therapy, as well as the number of required analgesic doses. We searched PubMed, Scopus, Embase, Web of Science, Cochrane Library, and gray literature from the date of database inception until May 2023. RevMan 5.4 software was used for data analysis. Twelve studies were considered eligible for meta-analysis. The mean pain scores on days 1 (mean difference [MD] = -1.69) and 2 (MD = -0.85) differed significantly between the apical patency and non-patency groups. The odds for pain after 24 h were significantly lower (OR 0.59) in the apical patency group than in the non-patency group. Furthermore, the mean number of required analgesic doses was not significantly different between the two groups. In conclusion, apical patency significantly alleviated postoperative pain (low-quality evidence) and reduced the incidence of pain (moderate evidence). However, high-quality randomized controlled trials are required to validate these findings.
BACKGROUND: Colon cancer is a prevalent invasive neoplasm in the gastrointestinal system with a high degree of malignancy. Despite extensive research, the underlying mechanisms of its recurrence and metastasis remain elusive.Rho GTPase activating protein 4 (ARHGAP4), a member of the small GTPases protein family, may be closely related to tumor metastasis, and its expression is increased in colon cancer. However, the role of ARHGAP4 in colon cancer metastasis is uncertain. This study investigates the impact of ARHGAP4 on the metastasis of colon cancer cells. Our objective is to determine the role of ARHGAP4 in regulating the invasive behavior of colon cancer cells.
METHODS: We downloaded colon adenocarcinoma (COAD) data from the Cancer Genome Atlas (TCGA), and performed differential analysis and survival analysis. By using the CIBERSORT algorithm, we evaluated the proportion of infiltrating immune cells in colon cancer. We further analyzed whether ARHGAP4 is associated with T cell exhaustion. Finally, we investigated the impact of ARHGAP4 knockdown on the migration and invasion of colon cancer cells through in vitro cell experiments. Additionally, we utilized western blotting to assess the expression of protein related to the TGF-β signaling pathway and epithelial-mesenchymal transition (EMT).
RESULTS: We found that ARHGAP4 is upregulated in colon cancer. Subsequent survival analysis revealed that the high-expression group had significantly lower survival rates compared to the low-expression group. Immune infiltration analysis showed that ARHGAP4 was not only positively correlated with CD8+ T cells, but also positively correlated with T cell exhaustion markers programmed cell death 1 (PDCD-1), cytotoxic T-lymphocyte associated protein 4 (CTLA-4), and lymphocyte activating 3 (LAG-3). In vitro cell experiments, the knockdown of ARHGAP4 inhibited the migration and invasion of colon cancer cells. Among EMT-related proteins, when ARHGAP4 was knocked down, the expression of E-cadherin was increased, while the expression of N-cadherin and Vimentin was decreased. Meanwhile, the expression of TGF-β1, p-Smad2, and p-Smad3, which are associated with the TGF-β/Smad pathway, all decreased.
CONCLUSION: ARHGAP4 promotes colon cancer metastasis through the TGF-β/Smad signaling pathway and may be associated with T cell exhaustion. It plays an important role in the progression of colon cancer and may serve as a potential target for diagnosis and treatment of colon cancer.
FLT190 is a recombinant adeno- associated viral (AAV) vector. Administered by a single intravenous infusion.
The invention discloses a targeting molecular probe based on a nucleic acid aptamer, a preparation method and application thereof, and relates to the field of biotechnology and molecular imaging. The preparation method comprises the following steps: preparing a nucleic acid aptamer-nuclide molecular probe precursor and labeling with a short half-life nuclide molecular probe. Molecular probes [  68  Ga]NOTA-SGC8 comprising SGC8 aptamer sequence, NOTA as ligand coupler and  68  ga radiocontrast agent. The application of the molecular probe in molecular imaging. The invention adopts aptamer targeting molecules to replace traditional antibody targeting molecules. The aptamer sequence can be synthesized entirely using a DNA synthesizer in the solid phase; the sequence can be personalized; the batch-to-batch variation is small. The reaction condition is simple, the stability is good, and the reaction is not influenced by temperature and pH value. The probe preparation method can be universally used for creating molecular probes aiming at other molecular targets and different nuclides.
The method of the present invention quantifies the severity of a subject's neurodegenerative disorder. The subject answers a questionnaire which results in a patient-reported outcome dataset. Benchmark tests are carried out by the subject performing one or more tasks resulting in a task result dataset. Continuous sensors collect data resulting in a sensor dataset. Short assessment tests of the subject are conducted resulting in a short assessment dataset. The patient-reported outcome dataset, task result dataset, sensor dataset, and short assessment dataset are aggregated into an output dataset that includes non-motor outcome measures and motor outcome measures. A single score is generated that quantifies the severity of a neurodegenerative disorder of the subject based on the output dataset.
NEW MATERIAL:A compound shown by the formula I or its salt. EXAMPLE:5-{4-[2-(3-Ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione. USE:A remedy for diabetes, having low toxicity. PREPARATION:A compound shown by the formula II is hydrolyzed by the use of a mineral acid (e.g., hydrochloric acid) in a solvent (e.g., methanol) to give a compound shown by the formula I. The reaction is carried out at 20-150 deg.C, preferably 50-100 deg.C for 0.5-20hr. The compound shown by the formula II is obtained by reacting a compound shown by the formula II with 4-fluoronitrobenzene in the presence of sodium hydride, etc. to give a compound shown by the formula IV, reducing catalytically this compound by the use of palladium carbon as a catalyst, diazotizing the resultant compound in the presence of an aqueous solution of hydrobromic acid, reacting further the reaction product with acrylic acid or its lower alkyl ester in the presence of a copper catalyst to give a compound shown by the formula V, and reacting the prepared compound with thiourea.
Adult day programs provide critical supports to both, older adults living in the community, and their family/friend caregivers. This is essential because ensuring high-quality care in the community for as long as possible and avoiding or delaying long-term care home admissions are key priorities of older adults, their caregivers, and healthcare systems. While most older adults in Canada receive care in the community, about 10% of newly admitted nursing home residents have relatively low care needs that could be met in the community with the right supports. Caregivers provide most of the care in the community, which puts them at high risk for caregiver burden. Day programs intend to mitigate these issues by providing respite to caregivers. However, research on the effectiveness of day programs is inconsistent. Generally, the methodological quality of studies is poor, and especially Canadian research is lacking. The research objectives are to (1) explore changes in patterns of day program use (including non-use) between provinces and over time, (2) compare characteristics of older adults with different day program use patterns (including non-use), and (3) assess whether day program attendees compared to a propensity score matched control group of non-attendees have better outcomes. This retrospective cohort study will use population-based clinical and health administrative data of older adults (65+ years) who received publicly subsidized continuing care in the community in Alberta, British Columbia, and Manitoba between January 01, 2012 and December 31, 2024. Patterns of day program use (i.e., variations in time to attend a day program for the first time, and frequency and duration of attendance) and how these patterns vary by province and over time will be assessed. Characteristics of older adults with different patterns of day program use (e.g., no, low, medium, high) will be compared. Characteristics of the participants will include age, sex, dementia status, frailty level, comorbidity status, socioeconomic status, availability of a caregiver, and caregiver distress. Finally, propensity-matched comparison group (by region, age, gender, cognitive/physical impairment, type/duration of community care received previously) of older adults who have not attended a day program will be created. Time-to-event models and general estimating equations will assess whether day program attendees compared to non-attendees enter continuing care facilities later (primary outcome); use emergency, acute, or primary care less frequently; experience less cognitive and physical decline; and have better mental health (secondary outcomes). Models will include day program exposure as an independent variable and will be adjusted for province, participant demographics, medical and functional conditions, caregiver availability/distress, other community services received (e.g., home care, in-home respite), and (if appropriate) matching variables.
BACKGROUND: Patients with chronic limb-threatening ischemia (CLTI) face a high long-term mortality risk. Identifying novel mortality predictors and risk profiles would enable individual health care plan design and improved survival. We aimed to leverage a random survival forest machine-learning algorithm to identify long-term all-cause mortality predictors in patients with CLTI undergoing peripheral vascular intervention.
METHODS AND RESULTS: Patients with CLTI undergoing peripheral vascular intervention from 2017 to 2018 were derived from the Medicare-linked VQI (Vascular Quality Initiative) registry. We constructed a random survival forest to rank 66 preprocedural variables according to their relative importance and mean minimal depth for 3-year all-cause mortality. A random survival forest of 2000 trees was built using a training sample (80% of the cohort). Accuracy was assessed in a testing sample (20%) using continuous ranked probability score, Harrell C-index, and out-of-bag error rate. A total of 10 114 patients were included (mean±SD age, 72.0±11.0 years; 59% men). The 3-year mortality rate was 39.1%, with a median survival of 1.4 years (interquartile range, 0.7-2.0 years). The most predictive variables were chronic kidney disease, age, congestive heart failure, dementia, arrhythmias, requiring assisted care, living at home, and body mass index. A total of 41 variables spanning all domains of the biopsychosocial model were ranked as mortality predictors. The accuracy of the model was excellent (continuous ranked probability score, 0.172; Harrell C-index, 0.70; out-of-bag error rate, 29.7%).
CONCLUSIONS: Our random survival forest accurately predicts long-term CLTI mortality, which is driven by demographic, functional, behavioral, and medical comorbidities. Broadening frameworks of risk and refining health care plans to include multidimensional risk factors could improve individualized care for CLTI.
1,195,384. Non-thrombogenic films and hollow artificial fibres. DOW CHEMICAL CO. 13 July, 1967 [21 July, 1966], No. 32307/67. Heading B5B. [Also in Divisions B1 and C3] Thrombogenicity is inhibited in articles of organic film or fibre-forming polymeric material having dialkylaminoalkyl groups attached to the polymer chains through ether linkages by reacting the material with an alkyl halide and reacting the resultant product with an alkali metal salt of a cationic group-containing antithrombogenic compound such as heparin or a heparinoid compound. The term "articles" is defined as meaning films, thin, pliable non- fibrous sheets and hollow fibres having an axial cavity extending throughout their length so that liquid can flow through the fibres from one end to the other. The dialkylaminoalkyl polymeric material may be prepared by converting at least a portion of the hydroxyl groups of a hydroxyl group-containing polymeric material to oxy alkali metal groups and reacting the product with a haloalkyl dialkyl amine. The hydroxyl group-containing material may be a cellulose, such as a regenerated cellulose, or may be prepared by treating a film-forming and/or a fibre-forming cellulose ester, such as cellulose acetate, with an aqueous solution of an excess of an alkali metal hydroxide. The aqueous solution may contain a water-soluble swelling agent for the cellulose ester, such as dimethyl sulphoxide, dimethylformamide, N-methylformamide, dimethylacetamide or tetramethylene sulphone or a ring-substituted derivative thereof. The article of the invention may be in the form of one or a bundle of hollow fibres. The hydroxyl group-containing polymeric material may be polyvinyl alcohol, hydroxy ethyl cellulose or hydroxyethylcarboxymethyl cellulose. Alternatively, polymeric materials that have grafted upon their surfaces hydroxy-containing materials may be employed, e.g. hydroxy terminated grafts of alkylene oxides on polyamides and polyesters. Normally the polymeric materials that are treated are in the desired article shape namely a film or fine hollow filaments, before being heparinized, but the polymeric material may be treated while in the form of granules, powders or other shapes and subsequently shaped into films or hollow filaments. The latter may be produced by melt spinning cellulose acetate plasticized with tetramethylene sulphone or a related ring-substituted derivative combined with a polyol. An artificial kidney may be comprised of a number of fine filamentary hollow fibres that have been treated according to the invention.
<P>PROBLEM TO BE SOLVED: To provide a specific binding member binding human ED-B, containing an antigen-binding part comprising an antibody VH domain and an antibody VL domain.  <P>SOLUTION: Provided are selectively targeting tumoral vasculature in vivo using a human recombinant scFv, L19, to the angiogenesis marker ED-B domain of fibronectin. In preferred embodiments, a complete human IgG1 having the variable regions of L19 is employed. In other embodiments a mini-immunoglobulin generated by fusing the scFv L19 to the constant CH4 domain of a secretory IgE isoform that naturally contains a cysteine in its COOH terminal and which forms a covalently linked dimer is employed. Different in vivo behavior of the antibody formats is exploitable for different diagnostic and/or therapeutic purposes, depending on clinical needs and disease. The antibody molecules may be labelled as described.  <P>COPYRIGHT: (C)2010,JPO&INPIT
FIELD: organic chemistry. SUBSTANCE: products: new 1,2-dihydro-2-oxopyridines of the formula (I)   where R means the group of the formula   where R 1 -R 3  and X have indicated values, and their salts that show antagonistic properties with regard to angiotensin II. Pharmaceutical composition showing angiotensin II-antagonistic activity containing compound (I)   at amount 1-1000 mg per a dose and pharmaceutically acceptable carrier. Synthesized compounds can be used for treatment of hypertension, aldosteronismis and cardiac failure. EFFECT: improved method of synthesis. 3 cl, 1 tbl
Hernia surgery is a widely performed procedure, and the use of a polypropylene mesh is considered the standard approach. However, the mesh often leads to complications, including the development of scar tissue that wraps around the mesh and causes it to shrink. Consequently, there is a need to investigate the relationship between the mesh and scar formation as well as to develop a hernia mesh that can prevent fibrosis. In this study, three different commercial polypropylene hernia meshes were examined to explore the connection between the fabric structure and mechanical properties. In vitro dynamic culture was used to investigate the mechanism by which the mechanical properties of the mesh in a dynamic environment affect cell differentiation. Additionally, electrospinning was employed to create polycaprolactone spider-silk-like fiber mats to achieve mechanical energy dissipation in dynamic conditions. These fiber mats were then combined with the preferred hernia mesh. The results demonstrated that the composite mesh could reduce the activation of fibroblast mechanical signaling pathways and inhibit its differentiation into myofibroblasts in dynamic environments.