anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
• Introduction and rationale Patients experiencing problems with their conventional maxillary denture can benefit from implant-retained overdentures (IODs). Several retention systems are available. These retention systems can be roughly divided into bar-retained IODs, in which multiple implants are splinted and the overdenture is attached through retentive clips, and into retention systems using non-splinted solitary attachments. Bar-retained IOD's provide good retention, require little maintenance, but are more expensive than solitary attachments. Medium term results of bar-retained IODs are promising with high implant and overdenture survival and low incidence of complications and may be considered the gold standard. Solitary attachments serve as an alternative to bars. These attachments are more economical and are easy to clean by the patient, but wear more easily, which can cause lack of retention. However, replacement of these attachments can often be done chair side. A recent review reported that, when a maxillary IOD is supported by four implants, both types show equal implant survival, overdenture survival and patient satisfaction. However, these conclusions are based on a limited amount of randomized controlled trials. Moreover, most studies reporting on solitary attachments were retrospective. Evidence on maxillary IOD attachment systems has been mostly short to medium term, non-comparing or retrospective and therefore inconclusive. This underlines the need for studies comparing different attachment systems with a longer follow-up.

The study design is an observational study to compare treatment outcomes of fully edentulous patients with maxillary IODs, supported by four implants, retained by either bars or Locators. Patients were treated 10 years ago with dental implants and an overdenture in the maxilla because of problems with retention and stability with their conventional denture. Outcomes: primary outcome is the change in marginal peri-implant bone level 10 years after placing the overdenture. Secondary outcome measures will be implant and overdenture survival, peri-implant mucosa health and patients' satisfaction using a questionnaire.
Pre-assessment measurements included big toe strength, vertical and horizontal jump heights, Y-balance for balance, and T-tests for agility. Following pre-assessment, participants followed a structured toe-strengthening protocol, performing 15 repetitions in three sets twice a day for 4 weeks. Post-intervention measurements, using the same units and instruments, aim to reveal the effects of the intervention on specified physical variables. This research provides insights into the potential benefits of combining toe-strengthening exercises with running training for enhanced physical performance.
PURPOSE: The fragmented nature of the medical device market limits our understanding of how particular sub-markets navigate the device development process. Despite the widespread use of transcutaneous neuromuscular electrical stimulation (NMES), its use for acquired dysarthria treatment has not been sufficiently explored. This study aims to provide a preliminary understanding of the stages involved in the development of NMES devices designed for neurorehabilitation. It also aims to investigate manufacturers' perceptions concerning factors that facilitate or impede its development and determine its applicability for acquired dysarthria.
MATERIALS AND METHODS: In-depth semi-structured online interviews were conducted with eight NMES device manufacturers located across Europe, North America and Oceania. The interviews were video-recorded, automatically transcribed, manually reviewed, and analysed using a qualitative content analysis.
RESULTS: NMES device development for neurorehabilitation involves six complex phases with sequential and overlapping activities. Some emerging concepts were comparable to established medical device models, while others were specific to NMES. Its adaptability to different neurological disorders, the positive academia-industry collaborations, the industry's growth prospects and the promising global efforts for standardised regulations are all key facilitators for its development. However, financial, political, regulatory, and natural constraints emerged as barriers. Indications and challenges for the applicability of NMES for acquired dysarthria treatment were also discussed.
CONCLUSION: The findings provide a foundation for further investigations on the NMES market sub-sector, particularly in the context of neurorehabilitation. The study also provides insights into the potential adoption of NMES for acquired dysarthria, which can serve as a reference for future research.
METHODS: This study assessed data from two cohorts of patients with alpha-synucleinopathies (University of Brescia and University of Rome Tor-Vergata cohorts). Consecutive participants with video-polysomnography-confirmed iRBD, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and controls underwent neurological, clinical and 123I-FP-CIT SPECT imaging assessments. Individuals with iRBD were longitudinally monitored to collect clinical phenoconversion to PD or DLB. The main outcome was to identify whole brain 123 I-FP-CIT SPECT measures reflecting monoaminergic deficits in each clinical group as compared to controls.
RESULTS: The cohort (n = 184) included 45 patients with iRBD, 47 PD, 42 DLB and 50 age-matched controls. Individuals with iRBD were categorized as RBD-DAT- (n = 32) and RBD-DAT+ (n = 13), according to nigrostriatal assessment used in clinical practice. Compared to controls, RBD-DAT- showed an early involvement of the left insula, which increased in RBD-DAT+, and was present in patients with Parkinson's disease and dementia with Lewy bodies. Longitudinal cox regression analyses revealed a higher risk of phenoconversion in individuals with iRBD and insular monoaminergic deficits [HR = 3.387; CI 95%: 1.18-10.27].
INTERPRETATION: In this study, altered insular monoaminergic binding in iRBD was associated with phenoconversion to DLB or PD. These findings may provide a helpful stratification approach for future pharmacological or non-pharmacological interventions.
Disclosed is a ewe synchronized estrus vagina plugging device and a preparation method. The plugging device is in a Y-shaped structure and is composed of a plastic framework, cylindrical-slice-layer-shaped silicon rubber drug sustained-release caps, and a plastic pull rope. Two cylindrical-slice-layer-shaped silicon rubber drug sustained-release caps are sleeved on two upper forks of the Y-shaped plastic framework, each cylindrical-slice-layer-shaped silicon rubber drug sustained-release cap is manufactured by mixing of double components of vinyl silicon rubber, a silicon rubber cross-linking agent, an acetic acid flugestone powder, and a stearic acid modifying agent in a proportioning and injection molding mode. When the ewe synchronized estrus vagina plugging device is used, components of the device are assembled. The ewe synchronized estrus vagina plugging device is placed inside a ewe vagina, and a main component of efficacy of each cylindrical-slice-layer-shaped silicon rubber drug sustained-release cap is acetic acid flugestone hormones, the acetic acid flugestone hormones are slowly released inside the ewe vagina, and after the acetic acid flugestone hormones are absorbed by organisms, the natural estrus phenomenon of a ewe can be restrained. After 9-15 days, the ewe synchronized estrus vagina plugging device is fetched out and then inhibition effect is immediately removed and then the ewe quickly falls into an estrus state. The synchronized estrus vagina plugging devices for ewes can be applied to a group of ewes so that the estrus state of the group of ewes can be controlled, and accordingly the purpose of regulating and controlling the estrus of the group of the ewes in a man-made mode is realized. The drug efficacy is removed once, the group of ewes with different estrus periods can be controlled to fall into the estrus state in the same time approximately and the purpose of controlling animal estrus in a man-made mode can be realized, and besides, the ewe synchronized estrus vagina plugging device and the preparation method can enable the ewes to mate simultaneously, enable the ewes to lamb simultaneously, save labor and materials, improve management efficiency, and improve surviving rate of young stocks.
The invention discloses ginger tea electuary and a preparation method thereof. The ginger tea electuary is prepared from the following raw materials: zingiber mioga (Thunb.) rosc., rhizoma atractylodis macrocephalae preparata, rhizoma atractylodis, radix saposhnikoviae, pericarpium citri reticulatae, radix glycyrrhizae, bulbus allii fistulosi, fructus lycii, plumula nelumbinis, grape seeds, rhizoma dioscoreae, chrysanthemum morifolium ramat, herba menthae, fructus jujubae, an inclusion agent, brown sugar, nigecose, dextrin, a plasticizer and an adsorbent. pungent and hot zingiber mioga (Thunb.) rosc. is used as monarch drug of the ginger tea electuary, rhizoma atractylodis macrocephalae which has effects of strengthening the spleen and drying damp is used as ministerial drug, rhizoma atractylodis and radix saposhnikoviae which have effects of expelling wind and removing dampness are used as adjuvant drug, pericarpium citri reticulatae which has effect of eliminating dampness by warm and can invigorate the spleen and promoting circulation of qi is also used as adjuvant drug, radix glycyrrhizae, bulbus allii fistulosi, fructus lycii, plumula nelumbinis, grape seeds, rhizoma dioscoreae, chrysanthemum morifolium ramat, herba menthae, fructus jujubae and the like are used as auxiliary materials, in a preparation method, combined action of a supercritical CO2 extraction method and ethanol extraction is implemented, and effective ingredients of main materials and the auxiliary materials are fully utilized to carry out comprehensive regulation. The ginger tea electuary has effects of benefiting vital qi and blood, strengthening the spleen to dry, and expelling pathogenic wind and relieving pain to treat emesis and singultus, abdominal pain and gastric abscess, loose stool and greasy fur, and limb joint pain which are caused by attack of pathogenic cold, eating and drinking without temperance and weakness of the spleen and stomach.
Oral squamous cell carcinoma is the predominant subtype of head and neck squamous cell carcinoma, characterized by a challenging prognosis. In this study, we established a murine model of oral carcinogenesis using 4-nitroquinoline-1-oxide (4-NQO) induction to investigate the impact of immunotherapy on microenvironmental alterations. Mice in the precancerous condition were randomly divided into two groups: one receiving programmed death-1 (PD1) monoclonal antibody treatment and the other, control immunoglobulin G. Our observations showed that while PD1 blockade effectively delayed the progression of carcinogenesis, it did not completely impede or reverse it. To unravel the underlying reasons for the limited effectiveness of PD1 blockade, we collected tongue lesions and applied mass cytometry (CyTOF) and RNA sequencing (RNA-seq) to characterize the microenvironment. CyTOF analysis revealed an increased macrophage subset (expressing high levels of IFNγ and iNOS) alongside a diminished Th1-like subset (exhibiting low expression of TCF7) and three myeloid-derived suppressor cell subsets (displaying low expression of MHC Class II or IFNγ) following anti-PD1 treatment. Notably, we observed an increased presence of cancer-associated fibroblasts (CAFs) expressing collagen-related genes after PD1 blockade. Furthermore, we found a negative correlation between the infiltration levels of CAFs and CD8+ T cells. These findings were validated in murine tongue tissue slides, and publicly available multi-omics datasets. Our results suggest that CAFs may impair the therapeutic efficacy of PD1 blockade in oral carcinogenesis by the remodeling of the extracellular matrix.
The present invention discloses a medicine for treating pain caused by wind-cold-dampness arthromyodynia, which is prepared from 16 Chinese herbal medicines, such as girald daphne bark, suberect spatholobus stem, common floweringquince fruit, slenderstyle acanthopanax bark, ledebouriella root, pubescent angelica root, large-leaf gentian root, notopterygium root, etc. The present invention also discloses a method for preparing the medicine. The medicine of the present invention has the efficiency of expelling wind, clearing away cold, removing moisture, promoting blood circulation for removing obstruction in collaterals and alleviating pain. The present invention is mainly used for treating the pathological symptoms, such as pain in the whole body, limb anesthesia, the aching of waists and knees, etc., caused by wind-cold-dampness arthromyodynia. The present invention is used for treating the pain of limbs and joints with manifestations, the limitation of movement, the inconvenience of activity, the thinness and the whiteness of coated tongues, floating pulses or trichiasis, and the symptoms belongs to patients with pain caused by wind-cold-dampness arthromyodynia through syndrome differentiation of the Chinese medicine. After clinical trial, the present invention has the advantages of quick action, obvious effects and no adverse reaction.
Placental health and foetal development are dependent upon element homeostasis. Analytical techniques such as mass spectroscopy can provide quantitative data on element concentrations in placental tissue but do not show spatial distribution or co-localisation of elements that may affect placental function. The present study used synchrotron-based X-ray fluorescence microscopy to elucidate element content and distribution in healthy and pathological placental tissue. The X-ray fluorescence microscopy (XFM) beamline at the Australian Synchrotron was used to image trace metal content of 19 placental sections from healthy term (n = 5, 37-39 weeks), foetal growth-restricted (n = 3, <32 weeks, birth weight <3rd centile), postdate (n = 7, >41 completed weeks), and stillbirth-complicated pregnancies (n = 4, 37-40 weeks). Samples were cryo-sectioned and freeze-dried. The concentration and distribution of fourteen elements were detected in all samples: arsenic, bromine, calcium, chlorine, copper, iron, molybdenum, phosphorous, potassium, rubidium, selenium, strontium, sulphur, and zinc. The elements zinc, calcium, phosphorous, and strontium were significantly increased in stillbirth placental tissue in comparison to healthy-term controls. Strontium, zinc, and calcium were found to co-localise in stillbirth tissue samples, and calcium and strontium concentrations were correlated in all placental groups. Molybdenum was significantly decreased in stillbirth, foetal growth-restricted, and postdate placental tissue in comparison to healthy-term samples (p < 0.0001). Synchrotron-based XFM reveals elemental distribution within biological samples such as the placenta, allowing for the co-localisation of metal deposits that may have a pathological role. Our pilot study further indicates low concentrations of placental molybdenum in pregnancies complicated by foetal growth restriction, postdate delivery, and stillbirth.
This is a case-control series comparing a strategy using a computer-based contrast induced nephropathy (CBCIN) risk tool in patients undergoing PCI versus usual care. Only inpatients will be included in this study. These inpatients will be compared to historical controls obtained using the medical record of age- and gender-matched inpatients who underwent cardiac catheterization with at least two consecutive daily post-procedure creatinine values. The percentage PCI will be matched in the retrospective series.

In the prospective group, the operator will be exposed to the CBCIN risk tool before and during care delivery with estimated CIN risk. The CBCIN risk tool estimates CIN risk based on the status of known risk factors (and suggests an associated standard hydration strategy based on left-ventricular end-diastolic pressure), which are automatically prepared from the patient's Electronic Medical Record and presented to the operator for review. This functionality has been evaluated in previous research and was found to be stable and reliable. Based on the data presented by and reviewed in the CBCIN risk tool, the operator may use the information and adjust therapy as clinically indicated (i.e. the risk tool is not the basis for clinical decisions). Following the PCI, serum creatinine will be measured as per treating physician, but those who undergo at least two consecutive daily serum creatinine measurements starting the day after the procedure will be included in the study. These patients will be called 6 months and 12 months post-procedure to determine mortality and re-hospitalization status.
Standard Care + Interactive Voice Response (IVR) System Participants will return with the caregiver on day 15 to complete a questionnaire lasting 30 minutes. Phone calls made once daily, each taking about 3-5 minutes to complete.
Stroke is a major cause of debilitation in the first world, with few therapeutic options when it comes to improvement in quality of life and morbidity, besides physical and occupational therapy. It affects people of all nationalities, creeds, and socioeconomic classes through a narrow array of mechanisms. With all those mechanisms, a common outcome is shared: derangement of the brain parenchymal architecture. This derangement is non-selective in its destruction with obscuration of the blood brain barrier and the glymphatic system, and with bleeding as a common sequela; the oxidative stress of the hemoglobin-heme-iron compound causing further injury. This study will measure Interleukin 6 (IL-6), a well-documented inflammatory biomarker that is increased in the acute phase of stroke, and to compare its levels after the administration of melatonin - a well-documented anti-inflammatory and anti-oxidant - that regulates circadian rhythm, which helps promote sleep. Any increased time spent in a restful state because of melatonin increases the clearance of waste products after a catastrophic event, like in stroke.
The present invention relates to a mother-baby granule and a preparation method thereof. The granule is prepared from traditional Chinese medicines, comprising astragalus root, angelica, white peony root, poria cocos, glycyrrhiza, seed of cowherb, chuanxiong rhizome, bitter orange, balloonflower, etc. Traditional Chinese medicines added with water are decocted, filtered and condensed to be the extract. Beta-cyclodextrin is added into the extract to be sprayed and dried into medicine powder, and then, the mother-baby granule is obtained by adding pregelatinized starch to the medicine powder for granulating and finishing granules. The mother-baby granule has the lactation-promoting comprehensive therapeutic effect of traditional soup preparations, and has the advantages of easy absorption and quick effect taking. If made into granules, the mother-baby granule is easy to store, carry and take.
Embodiments of the invention relate to systems and methods for creating a form for receiving data relating to a health care incident. A dictionary of field objects is provided in a metabase, where a field object defines attributes, and an instance of a field object is a form field. A request to create a user-defined field object is received and it is determined that the user-defined field object is not in the dictionary of field objects in the metabase. The user-defined field object is generated by defining attributes for the user-defined field object, where at least one attribute is a presentation attribute for a form field within a form. The user-defined field object is added to the dictionary of field objects in the metabase and the user-defined field object is linked to a data location in a persistent store. The form is generated, where the form is an ordered collection of form fields, where at least one form field is an instance of the user-defined field object and is displayed according to the at least one presentation attribute.
Participants receive Eribulin or Vinorelbine or Gemcitabine or Capecitabine in the first cycle (3 weeks). Participants with clinical benefit could receive additional treatment for more cycles. The administration will be terminated because of disease progression or intolerable toxicity occurring or other reasons.
This procedure involves passing a mucosal impedance probe through the endoscope and gently placing the tip of the probe on the esophageal mucosa. Measurements will be made at 2,5,10 and 15 cm above the gastroesophageal junction. There is no increased risk to the procedure and it adds approximately 2 minutes to the procedure.
<P>PROBLEM TO BE SOLVED: To provide a method for monitoring IL-18.  <P>SOLUTION: The present invention relates to the method suitable for monitoring IL-18. The present invention also provides a method for measuring IL-18 in a human body fluid for the purpose of diagnosing disease and evaluating the response to ICE inhibitor or other therapy. These methods are useful in discovering or developing compounds that modulate IL-18. Monitoring IL-18 levels provides a method for monitoring both IL-18-mediated and IL-1 β mediated disease processes.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Novel Outpatient Occupational Therapy Intervention using chronic illness management strategies, yoga, meditation for disordered eating. 8-weeks with 2 visits per week each lasting 1 hour.
Adult patients (aged \>18 years) will be enrolled as they present for emergency or immediate medical care, in facilities such as the intensive care unit (ICU), cardiac care unit (CCU), and/or other departments. Subjects may or may not have a clinical indication for ultrasound scanning as part of their regular medical care and will be required to meet the inclusion criteria and none of the exclusion criteria. Eligible subjects will undergo an ultrasound exam using the investigational ultrasound device. The exam type will be based on the subject's clinical condition. Users performing the scans will periodically be asked to provide feedback on User Survey forms prepared by the Sponsor. Image data sets from investigational exam will be stored electronically and de-identified data will be disclosed to the Sponsor.Results are for use in development and optimization of a next generation ultrasound system being developed by study Sponsor, GE Healthcare (GEHC) prior to future commercial release.
BACKGROUND: Toll-like receptors (TLRs) are a family of transmembrane receptors that play key roles in identifying invading pathogens and activating innate immunity. TLR1 has been reported to be associated with the risk of gastric cancer (GC) but that was based on only a simple statistical analysis.
METHODS: We genotyped the TLR1 in 526 GC patients to investigate the association between the variation and gastric cancer survival by the multiplex polymerase chain reaction and sequencing method. The rs4833095 variation (chr4:38798089 [GRCh38. p14], T > C) in the TLR1 gene was genotyped in 526 patients who underwent GC resection. The associations between genotype, survival, and recurrence were investigated. The potential role of TLR1 in stomach cancer was investigated using clinical data from formalin-fixed, paraffin-embedded tissue samples.
RESULTS: Patients with the T/C and C/C genotypes of rs4833095 had a lower risk of recurrence than those with the T/T genotype. Recurrence-free periods were substantially longer in patients with the T/C or C/C genotypes (22.6 and 22.3 months, respectively) than in those with the T/T genotype (20.7 months). Patients with the T/C or C/C genotype, low expression levels of VEGF1, high expression levels of ERBB2 and ERCC1, the absence of cancer nodules, a tumor size of less than 5 cm, and poor differentiation had a considerably reduced risk of recurrence.
CONCLUSIONS: TLR1 rs4833095 was correlated with the postresection prognosis of patients with gastric cancer, suggesting that TLR1 may have a role in the onset or progression of gastric cancer.