anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Robotic transanal minimally invasive surgery (R-TAMIS) was introduced in 2012 for the excision of benign rectal polyps and low grade rectal cancer. Ergonomic improvements over traditional laparoscopic TAMIS (L-TAMIS) include increased dexterity within a small operative field, with possibility of better surgical precision. We aim to collate the existing data surrounding the use of R-TAMIS to treat rectal neoplasms from cohort studies and larger case series, providing a foundation for future, large-scale, comparative studies.
METHODS: Medline, EMBASE and Web of Science were searched as part of our review. Randomised controlled trials (RCTs), cohort studies or large case series (≥ 5 patients) investigating the use of R-TAMIS to resect rectal neoplasia (benign or malignant) were eligible for inclusion in our analysis. Quality assessment of included studies was performed via the Newcastle Ottawa Scale (NOS) risk of bias tool. Outcomes extracted included basic participant characteristics, operative details and histopathological/oncological outcomes.
RESULTS: Eighteen studies on 317 participants were included in our analysis. The quality of studies was generally satisfactory. Overall complication rate from R-TAMIS was 9.7%. Clear margins (R0) were reported in 96.2% of patients. Local recurrence (benign or malignant) occurred in 2.2% of patients during the specified follow-up periods.
CONCLUSION: Our review highlights the current evidence for R-TAMIS in the local excision of rectal lesions. While R-TAMIS appears to have complication, margin negativity and recurrence rates superior to those of published L-TAMIS series, comparative studies are needed.
Sunitinib will be administered at a dose of 50 mg orally once daily for four consecutive weeks, followed by a two-week rest period. Intra-patient dose reduction may be required depending on the type and severity of individual toxicity encountered. Imaging studies will be performed after every other cycle. Patients may continue on study as long as they are tolerating treatment and in the absence of disease progression.
SHARE! the Self-Help and Recovery Exchange will engage peer workers in their Peer Toolkit training, which is designed to improve the performance of peer workers in their provision of peer support. The training covers each of the 12 tools in the Peer Toolkit, which are taught through brief presentations followed by group discussions and interactive exercises to help people competently use each of the tools. The training is offered both online and in-person, requires 60 hours of time, and is typically completed over the course of 4 months. Participation in the training is optional.

The Peer Toolkit training currently has a waitlist of peer workers interested in taking the course for professional development purposes. These peer workers and their supervisors will be invited to complete a web-based survey at baseline and 4-month follow-up. Peer workers will be randomly assigned to enroll in the Peer Toolkit training immediately or after the follow-up survey. Analyses will compare participants who had the opportunity to complete the training to those who are still waiting to start the training. This study will inform the use of the Peer Toolkit as a training mechanism to build the capacity of peer workers in the mental health workforce.
Pseudolymphomatous cutaneous angiosarcoma (cAS) is a rare subtype characterized by a prominent lymphocytic infiltrate, posing diagnostic challenges due to its resemblance to lymphoid neoplastic processes. We present a novel case highlighting the clinical and histopathological features, notably its association with persistent firm facial edema in a patient with systemic sclerosis (SSc). A 47-year-old woman with a 21-year history of SSc presented with firm palpebral edema evolving to involve the entire face and cervical region over six months. Diagnostic imaging revealed inflammatory changes in orbital regions, supradiaphragmatic lymphadenopathies, and lytic lesions. Skin biopsy demonstrated a diffuse neoplasm with vascular channels and solid areas, accompanied by dense lymphocytic proliferation. Pseudolymphomatous cutaneous angiosarcoma, a rare malignant neoplasm, exhibits variable clinical presentations and rapid progression. Histologically, it manifests as irregularly shaped vascular channels lined by prominent endothelial cells. Immunohistochemistry, particularly markers such as v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG), aids in diagnosis. Notably, this case marks the first presentation of cAS with persistent facial edema in SSc, highlighting the association between SSc and cancer risk. This case underscores the diagnostic challenges posed by cAS and emphasizes the importance of early detection for optimal patient outcomes. Further understanding of its association with autoimmune disorders such as SSc is crucial for comprehensive management strategies.
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the adult brain which mediates its rapid effects on neuronal excitability via ionotropic GABAA receptors. GABA levels in the brain are critically dependent upon GABA-aminotransferase (GABA-AT) which promotes its degradation. Vigabatrin, a low-affinity GABA-AT inhibitor, exhibits anticonvulsant efficacy, but its use is limited due to cumulative ocular toxicity. OV329 is a rationally designed, next-generation GABA-AT inhibitor with enhanced potency. We demonstrate that sustained exposure to OV329 in mice reduces GABA-AT activity and subsequently elevates GABA levels in the brain. Parallel increases in the efficacy of GABAergic inhibition were evident, together with elevations in electroencephalographic delta power. Consistent with this, OV329 exposure reduced the severity of status epilepticus and the development of benzodiazepine refractory seizures. Thus, OV329 may be of utility in treating seizure disorders and associated pathologies that result from neuronal hyperexcitability.
In the market, a great variety of heat-clearing and detoxifying herbal tea, such as heat-free herbal tea and Wong Lo Kat herbal tea, are available, however, heat-clearing and detoxifying medicinal liquor is not available yet. Since liquor is a product with great heat, it is quite difficult to make the medicinal liquor with great heat naturally to have heat-clearing and detoxifying functions. Some people are addicted to liquor and want to drink liquor three meals a day, so that these people are prone to alcoholism. If a kind of liquor capable of clearing heat and detoxifying, as well as preventing alcoholism is available. It is satisfactory if the purposes of clearing heat, detoxifying and preventing alcoholism can be achieved when the people drink. The invention discloses a preparation method of the heat-clearing and detoxifying medicinal liquor. According to the preparation method, the heat-clearing and detoxifying medicinal liquor is prepared from several kinds of Chinese herbs capable of clearing heat and detoxifying as well as preventing alcoholism and sobering via processing. For long-time drinking, effects of preventing diseases and preventing alcoholism can be achieved.
Alopecia areata (AA) is an autoimmune inflammatory disease characterized by non-scarring hair loss due to an immune response that targets hair follicles. The current treatment approach for AA involves the use of immunosuppressants and immunomodulators to reduce cytokine levels around affected hair follicles. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as potential anti-inflammatory agents with diverse beneficial effects in various medical conditions. This study investigates the role of beta-hydroxybutyrate (BHB), a ketone body produced during SGLT2 inhibition, in the pathogenesis of AA. Serum BHB levels were found to be significantly elevated in patients with AA compared with healthy controls, with higher levels correlating with severity of hair loss. BHB treatment increased inflammatory cytokine production in outer root sheath (ORS) cells, mimicking the inflammatory conditions seen in AA. The results suggest that elevated BHB levels may exacerbate the inflammatory immune response in AA patients and may be associated with chronic hair loss and resistance to treatment. Serum BHB levels may serve as a potential marker of poor prognosis in patients with severe AA. Further research is needed to elucidate the precise role of BHB in the pathogenesis of AA and its implications for disease management.
BACKGROUND: Trapezio-metacarpal osteoarthritis is a common condition for which the reference standard treatment after failure of non-operative measures is trapeziectomy. Several techniques have been devised to avoid proximal migration of the first metacarpal bone (M1) with impingement on the scaphoid bone. We have developed a Gore-Tex® ligament reconstruction technique that avoids potential complications of tendon harvesting. The objective of this study was to assess the long-term outcomes of this technique.
HYPOTHESIS: Trapeziectomy with Gore-Tex® ligament reconstruction is a reliable option for providing lasting pain relief in patients with trapezio-metacarpal osteoarthritis.
MATERIALS AND METHODS: We conducted an observational, single-centre, single-surgeon, retrospective cohort study in consecutive patients managed by primary trapeziectomy. We excluded patients with revision trapeziectomy or less than 10 years' follow-up. The primary outcome was event-free survival, defined as absence of revision surgery and of a numerical rating scale score for pain above 3/10. The secondary criteria were clinical tolerance of the Gore-Tex® implant and radiological changes. The patients were assessed at last follow-up either in person or during a teleconsultation.
RESULTS: Of 78 included joints, 54 were assessed during patient visits and 24 by teleconsultation. At 10 years, the event-free survival rate was 91.3%, and 60.3% of patients were free of pain. Evidence of osteolysis was visible in 24% of patients. No patient experienced clinical intolerance of the Gore-Tex® implant. The mean Disabilities of Arm, Shoulder and Hand score was 25.5. Metacarpo-phalangeal hyperextension was significantly increased, to 30.6°, and the mean trapezial space ratio was significantly decreased, to 39.1% of the baseline value.
CONCLUSION: Long-term event-free survival was high. Functional outcomes and pain were similar to previous reports. Trapeziectomy with Gore-Tex® ligament reconstruction obviates the need for tendon harvesting. Osteolysis developed in some patients but did not correlate with clinical intolerance. Long-term clinical and radiological monitoring is in order after Gore-Tex® implantation.
LEVEL OF EVIDENCE: IV, Observational, single-centre, single-surgeon, retrospective cohort study.
Embodiments herein provide a method for a patient to increase engagement with cognitive behavioral therapy by a system ( 100 ), which in turn will increase the efficacy of the therapy. The embodiment is meant to be used in a clinical setting, specifically in an outpatient group program with a supervising therapist that meets weekly, bi-weekly, or monthly. The embodiment uses machine learning (ML), a group component, and gamification to promote increased engagement. ML (natural language processing) is used to help the patient automatically classify his/her negative thoughts into a pre-set taxonomy of ‘cognitive distortions’ or retrieve a previously stored triple column entry. The group component allows for the patient to request help from his/her groupmates in between in-person meetings. Gamification provides an additional incent to participate in the therapy: Within groups, teams of three patients compete against each other by scoring points proportional to their engagement with the app.
The invention relates to Chinese medicine preparation for curing cancer and a method for preparing the same, which belong to the medicine technical field and are used for solving the problem of curing a plurality of cancers and particularly curing intermediate and advanced patients. The medicine preparation takes blue vitriol, realgar, centipede, cabardine, bornyl alcohol, secretio bufonis, scorpion, zaocys, woodlouse, raw oysters, honeycombs and herba salviae chinensis as raw materials which are prepared into pills through mixture and crushing. The medicine preparation is formed by excavation, sorting, research and development of a hereditary secret formula which is handed down for hundreds of years. The medicine preparation has strong medicine potency and obvious effect and has the function of curing and saving intermediate and advanced patients of a plurality of cancers. The functions of the medicine preparation are as follows: reducing edema and reducing phlegm, astringing and softening hard mass, resolving stasis and promoting menstruation, inducing vomiting and expelling toxin, detoxicating and alleviating pain, and anti-cancer and inducing resuscitation. The medicine preparation can be used for curing gastric cancer, lung cancer, liver cancer, skin carcinoma, breast carcinoma, intracranial tumour and other nameless malignant pyogenic infections. The medicine preparation is characterized by short taking time, quickness in taking effect and so on; the patients are required to take the medicine as directed by a physician severely; and the medicine plays a part in bringing the dying back to life on partial cancer patients as shown by clinical observation.
Asthma exacerbation is a common clinical occurrence. The causal factors are not fully understood yet. Environmental pollution is linked to asthma exacerbation. The objective of this study is to elucidate the role of 3-methyl-4-nitrophenol (MNP), an environmental pollutant, in asthma exacerbation. In this study, an airway allergy mouse model was established with ovalbumin as a specific antigen with or without the presence of MNP. The results showed that, in a mouse model, the intensity of airway allergy was significantly increased by exposure to MNP. RNAseq results showed an increase in endoplasmic reticulum (ER) stress-associated molecules and the Osm expression in airway epithelial cells of mice with airway allergy. Exposure of epithelial cells to MNP in culture induced the expression of oncostatin M (OSM) and ER stress associated molecules. The OSM receptor was expressed by macrophages. OSM could drive macrophages to produce tumor necrosis factor-α (TNF-α). Inhibition of PERK, one of the key molecules of ER stress, or depletion of OSM receptor in macrophages, could effectively attenuate the MNP/ovalbumin protocol induced airway allergy. To sum up, by promoting ER stress, environmental pollutant MNP can cause airway epithelial cells to produce OSM. The latter induces macrophages to produce TNF-α, which can exacerbate airway allergy.
OBJECTIVE: To compare the clinical outcomes of radial artery (RA) grafts during CABG to those of right internal mammary artery (RIMA) grafts.
METHODS: This was a retrospective, single-institution cohort study of isolated CABG with multiple grafts between 2010-2022. To balance graft cohorts, propensity score matching (PSM) was performed using a 1:1 match ratio. Long-term postoperative survival was compared among RA and RIMA groups. Similarly, major adverse cardiac and cerebrovascular events (MACCE) were compared among both cohorts, with MACCE comprising death, myocardial infarction (MI), coronary revascularization, and stroke. Kaplan-Meier estimation was performed for mortality, while cumulative incidence estimation was utilized for MACCE.
RESULTS: A total of 8,774 patients underwent CABG. Of those, 1,674 (19.1%) patients who underwent multiarterial CABG were included in this analysis. 326 (19.5%) patients received RA grafts and 1,348 (80.5%) received RIMA grafts. PSM yielded a cohort of 323 RA patients and 323 RIMA patients. After matching, groups were well-balanced across all baseline variables. No significant differences were observed in immediate postoperative complications or long-term survival, with 5-year survival estimates of 89.5% for the RA group vs 90.1% for the RIMA group. There was a nonsignificant trend toward a higher incidence of MACCE at 5 years in the RA group compared to the RIMA group (31.3% in the RA group vs 24.1% in the RIMA group), especially after 1-year follow-up (21.6% in the RA group vs 15.1% in the RIMA group). Specifically, for RA patients, there were higher rates of repeat revascularization in the 5-year postoperative period (14.7% in the RA group vs 5.3% in the RIMA group), particularly in the territory revascularized by the RA during the index operation (45.7% in the RA group vs 10.3% in the RIMA group).
CONCLUSION: Overall, RA and RIMA secondary conduits for CABG were associated with comparable immediate postoperative complications, 5-year MACCE, and 5-year survival after PSM. RA grafting was associated with significantly higher rates of repeat coronary revascularization at 5 years, specifically in the territory revascularized by the RA during the index operation.
In group 1, a three hundred micron laser fiber was used to conduct the laser energy. holmium laser pulse energy of approximately 1 joule was used that was generated from a Holmium laser Quanta device and total power of 15 watts. the laser fiber was aimed directly to the midline at 12 o'clock position to start the procedure and cut the fibrous tissue till access to a wide lumen.
Techniques for providing acoustic feedback are disclosed. Several audio clips (21-23) have a synchronized beat. A sensor signal (16) received from a sensor has a sensor signal range divided by first and second thresholds (11, 12) into at least three sensor signal sub-ranges (13-15). An audio signal is output in response to the received sensor signal (16), the output audio signal comprising one or more of the audio clips. If the received sensor signal (16) exceeds the first threshold (11), at least one (21) of the one or more audio clips is discontinued and/or at least one additional audio clip (22) of the audio clips is initiated in synchronization with the one or more audio clips (21). If the received sensor signal (16) falls below the second threshold (12), at least one (21) of the one or more audio clips is discontinued and/or at least one additional audio clip (23) of the audio clips is initiated in synchronization with the one or more audio clips (21).
BACKGROUND: Restorative proctocolectomy (RP) with ileal pouch-anal anastomosis (IPAA) remains the gold standard for the surgical management of patients with medically refractive mucosal ulcerative colitis. We aimed to identify functional and quality of life (QOL) outcomes in RP and IPAA surgery patients at our institution.
METHODS: A retrospective observational study was performed including all patients who had undergone RP and IPAA between August 1984 and November 2017 at Royal Prince Alfred Hospital (RPAH).
RESULTS: 316 consecutive patients were identified, median age 39 (range 5 to 81) years. The median duration of disease was 60 (range 1 to 528) months. Ulcerative colitis was the main preoperative diagnosis with the main RP indication being failure of medical treatment. The median postoperative stay post-IPAA was 11 (range of 5 to 67) days. Pouchitis was the most common late complication (22.1%), bleeding pouch (3.5%) the earliest, with a 6.8% rate of symptomatic anastomotic leak. Visual analogue scale QOL measure (P-value <0.001), St Marks incontinence score (P-value = 0.001) and Cleveland clinic score (P-value = 0.002) all revealed significant improvement in functional outcomes and QOL.
CONCLUSION: QOL and functional outcomes following RP with IPAA in patients at our institution are excellent and comparable to institutions with larger patient numbers.
PROBLEM TO BE SOLVED: To obtain a promoter for the synthesis of collagen and a glycosaminoglycan, comprising a midkeine as an active ingredient, having promoting actions on the synthesis of the collagen and the glycosaminoglycan in a human dermal fibroblast and useful as a therapeutic agent, etc., for dermatopathy such as a wound or burn. SOLUTION: This preparation for external use for skin comprises a midkeine(MK) as an active ingredient. When the medicine is preferably used for treating dermatopathy, it is administered in the dosage form such as an ointment, a cream, a lotion, a milky lotion or a gel for external use. A pharmacodynamically effective ingredient such as a tumor growth factor-β, interleukin-1, an epithelial growth factor, γ-interferon or an antimicrobial agent and further a mineral oil, an animal or a vegetable oil, an emulsifying agent, a gelling agent, water polyethylene glycols, a synthetic oil, etc., can be blended in addition to the MK. The amount of the MK blended is, e.g. 0.0001-50wt.%, especially preferably 0.0001-10wt.%.
PURPOSE:To obtain a compound, having marked vascularization-inhibitory activity, thus having excellent effect as a vascularization inhibitor. CONSTITUTION:This vascularization inhibitor consists of a compound selected from compounds of formulas I to IV and salts thereof. The compound of the formula I can be obtained by culturing a strain belonging to Bacillus thuringiensis var. gerehiae. The compound of the formula II can obtained by reacting a formic acid solution with the compound of the formula I, and the compound of the formula III can be obtained by reacting sodium nitrite with the compound of formula I in the presence of acetic acid. The compound of the formula IV can be obtained by dissolving the compound of the formula II and sodium nitrite in distilled water followed by dripping acetip acid to the resultant aqueous solution to conduct reaction. This vascularization inhibitor can be used for the treatment of diseases caused by vasohyperplasia such as diabetic retinopathy, rheumatic arthritis, immature baby retinopathy or senile xanthosis degeneration.
Placebo Capsule. MRI of cerebrum pre dose. Transcranial Doppler, near-infrared spectroscopy (NIRS), endothelial response with EndoPAT2000, and endothelial biomarkers (pre and post dose).
This is a single site, double-blind, placebo-controlled, crossover trial to quantify the effects of combination adjunctive therapy on glycemic control, ketogenesis during insulinopenia, insulin resistance, and diabetes burden and quality of life.

Up to 22 adult participants with type 1 diabetes (T1D) will be enrolled with at least 16 participants completing the study in full. After screening, baseline data (A1c, CGM, ambulatory insulin dosing, ambulatory ketones \[fasting and after infusion set change\], and psychosocial questionnaires) will be collected and participants will complete an insulin withdrawal test (IWT) and a hyperinsulinemic-euglycemic clamp (HEC) with indirect calorimetry (IDC). Participants will then receive 12-week insulin-adjunctive treatments with both: (1) SGLTi (sotagliflozin 200 mg daily) + Placebo and (2) SGLTi + GRA (volagidemab 35 mg weekly), in a random-order, cross-over design with a 14-week washout period between treatment periods. Throughout the treatment periods subjects will be seen weekly in clinic for medication dosing (GRA or placebo) and download/review of CGM, insulin, and ketone data. At the end of each treatment period, the baseline studies will be repeated. Subjects will return for a safety follow up visit 6 weeks after the final GRA or placebo dose.