anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a long life and weight reduction umbilical paste. The umbilical paste is made from the components with the following weight portions of 3-10 portions of prunus seeds, 5-10 portions of atractylodes, 10-20 portions of bitter orange, 3-10 portions of pubescent angelica, 10-20 portions of eupatorium fortune, 5-15 portions of bergamot, 3-6 portions of agastache, 10-30 portions of oil rice, 3-15 portions of aloe, 10-15 portions of radish seed, 10-15 portions of dodder, 3-9 portions of curcuma aromatica, 10-15 portions of areca peel, 3-10 portions of cassia twig, 10-20 portions of lanceolata and 10-20 portions of angelica. The umbilical paste is made by choosing natural genuine medicinal plants, and the umbilical paste is safe and has no side effects. The effects of body-building, weight reduction, body beauty, breast full-grown and long life can be achieved without diarrheaing, dieting, water dieting, active sporting, taking medicine and needle inserting. The umbilical paste can not cause the weakness of body without rebounding. The skin is not loosen after being reduced weight, especially, the breast is still plump.
BACKGROUND: The gut microbiota and its stability have important relationships with immunity. However, bibliometric analysis in this field is underdeveloped. This study aims to visualize publications related to the gut microbiota and immunity to identify research frontiers and hotspots, providing references and guidance for further research.
METHODS: Gut microbiota and immunity data were retrieved from the Web of Science Core Collection database, and Microsoft Excel, Scimago Graphica and VOSviewer software were used to analyze publication output trends, the most productive countries/regions, journals, authors, co-cited references, and keywords.
RESULTS: This study analyzed 16,611 publications, including 10,865 articles and 5746 reviews, and found a continuous increase in publications related to gut microbiota and immunity since 2013. We identified 62,872 authors contributing to this field from 2144 journals and 9965 organizations/institutions in 145 countries/regions. The top publisher with the highest output is University of California System with 525 papers. Among these journals, the top 3 most prolific journals are Frontiers in Immunology, Frontiers in Microbiology, and PLOS ONE. The literature with the highest citation frequency is published in Science and has been cited 3006 times by Patrick M. Smith and others.Gut microbiota research hotspots include gut microbiota inflammation, immune response, inflammatory bowel diseases (IBDs), and microbiota tumors. The gut microbiota and its microbial homeostasis play critical roles in immune reactions, inflammation, and even tumors and IBDs.Current research on gut microbiota and immunity is a popular field. Previous studies have shown that the gut microbiota and its microbial species have important effects on maintaining human health, immune function, inflammation, tumorigenesis, and IBDs. Understanding the roles of microbial communities and specific bacterial species as well as their interactions with humans has led to numerous discoveries that provide unique opportunities for exploring human health and future research.
CONCLUSION: This study used bibliometric and visualization analysis to identify the development trends and hotspots of publications related to the gut microbiota and immunity. The findings of this study provide valuable insights into the emerging trends and future directions in this field.
Cerebrospinal fluid (CSF)leak is caused by communication between the subarachnoid space and the air-filled spaces of the middle ear or para nasal sinuses and sometimes skin. CSF leaks can be divided into two types ,traumatic and non traumatic. The traumatic CSF leaks further divided into accidental and iatrogenic (post surgical procedures) 1. Almost 80% of CSF leaks are due to road traffic accidents, fall from heights and firearms injuries to brain and spine, 16% are iatrogenic, and 4% are non-traumatic 1,2. More than 50% of traumatic CSF leaks are evident within the first 02 days, 70% within the first week, and almost all present within the first 3 months \[2,3\]. It is estimated that in patients with skull base fracture 10-30% develops CSF leaks and 2% of all traumatic head injuries are associated with CSF leaks \[4\].With the help of conservative treatment most of the CSF leaks stop within 7-10 days 1,5. When the CSF leak doesn't stop after 7-10 days, a lumbar drainage (LD) is suggested3,7. LD(lumbar drain) is a recommended treatment method for the CSF leaks in skull base and spinal trauma, the indications for LD(lumbar drain ) placement are still controversial ,LD(lumbar drain) effect on early CSF leakage cessation is still arguable 2,3. Traumatic CSF leaks duration can be reduced by early( lumbar drain) placement . At tertiary level particularly in public hospital, our study will be helpful to document the benefits of early lumbar drain (LD) in traumatic CSF leakage patients and their hospital stay. This will also help to reduce the ambiguity regarding the protocol for early lumbar drain (LD) placement .
BACKGROUND: In the presence of non-complicated appendicitis, treatment typically involves a simple appendectomy and can even be managed medically. However, in cases of complicated appendicitis, surgery becomes more difficult, and the morbidity and mortality rates increase. This study aims to develop a method for recognizing complicated acute appendicitis operatively.
METHODS: This retrospective study developed a scoring system based on the Alvarado score. Several variables were scored in this new scoring system, including the Alvarado score, female gender, elevated direct bilirubin, increased appendicitis thickness, and the presence of complications as evidenced by imaging or appendicoliths.
RESULTS: The study included a total of 404 patients with a mean age of 38.50±12.94 years, all operated on for acute appendicitis. Of these, 45.8% were female. Complicated acute appendicitis was present in 25% of the patients. The presence of complicated acute appendicitis was identified with a sensitivity of 86.1% and a specificity of 90.4% in patients who scored 10.5 or above.
CONCLUSION: It is critical to identify perioperative and postoperative complications, provide appropriate patient counseling, and consider medical treatment when appropriate to diagnose acute complex appendicitis effectively. The new scoring system is an effective method for recognizing acute complicated appendicitis.
PURPOSE:To obtain a new compound having antitumor activity and useful for. the treatment of cancer. CONSTITUTION:8,9,10,11-Tetrahydro-11-oxoascididemin of the formula. Form, yellow powder having indefinite form; melting point, >=300 deg.C. The compound can be produced by disintegrating and homogenizing a sponge which belongs to the genus Biemna and collected at Untenko, Okinawa Prefecture, extracting e.g. with methanol, adding 1M saline water to the extract, extracting thrice with ethyl acetate, extracting the water layer with n-butanol and purifying the solvent-extracted component by silica gel column chromatography and sephadex column chromatography.
Changes in body shape are linked to swimming performance and become relevant for selective breeding programmes in cultured finfish. We studied how the selection for fast growth could affect phenotypes by investigating the relationship between swimming performance and body shape. We also investigated how swimming might affect plasma metabolite concentrations. Critical swimming speed (UCrit), body traits (e.g., BW, body weight; BL, body length; K, condition factor), and plasma lactate and glucose concentrations were evaluated in two cohorts of Australasian snapper (Chrysophrys auratus): one derived from wild broodstock (F1), and the other selected for fast growth (F4). UCrit tests (n = 8) were applied in groups of 10 snapper of similar BW (71.7 g) and BL (14.6 cm). The absolute or relative UCrit values of both cohorts were similar (0.702 m⋅s-1 and 4.795 BL⋅s-1, respectively), despite the F4 cohort displaying a higher K. A positive correlation between K and absolute UCrit (Pearson's r = 0.414) was detected in the F4 cohort, but not in the F1 cohort, which may be linked to differences in body shape. A negative correlation between relative UCrit and body size (Pearson's r between -0.682 and -0.501), but no correlation between absolute UCrit and body size, was displayed in both cohorts. Plasma lactate and glucose concentrations were higher in the F4 cohort at UCrit. Whether a longer selective breeding programme could result in more changes in body shape, potentially affecting swimming performance, should be explored, along with the potential outcomes of the differences in metabolic traits detected.
The patient will have an amount of 4 sessions (S3, S5, S7 and S9) for 1.5 months: 1 session every 2 weeks. The patient will receive rTMS active and active mirror-based therapy using virtual reality.
Heretofore morbidity and mortality in Zollinger-Ellison syndrome were caused by severe ulcer disease. The advent of specific drugs to cure ulcer disease now extends life until metastases from the non-B-islet cell tumor or other events cause death. Patients with metastatic gastrinoma that is not surgically resectable and that has increased in size over a 4-6 month period prior to the study will be treated with interferon-alpha, 5 million international units/day. The drug will be administered subcutaneously by the patient. Tumor response and side effects will be monitored. Patients will receive 6 months of therapy and if there is reduction or stabilization of tumor masses, therapy will continue as long as response is maintained.
The Subsequent 50 patients will be randomized to either placebo or BSS. The patients will be assigned by envelope containing a symbol for either active drug or placebo (or other suitable randomization event) by a member of the research team not directly involved in the clinical trial.
PROBLEM TO BE SOLVED: To prepare a hair cosmetic giving gloss, moist feeling, cohesiveness and smooth touch to hair and free from oil stain by mixing an amphoteric polymer and a polyoxyalkylene alcohol ether with a specific compound. SOLUTION: This cosmetic is prepared by mixing 0.05-15wt.% of an amphoteric polymer and 0.05-15wt.% of a polyoxyalkylene alcohol ether with 0.1-20wt.% of a cellulose ether. The amphoteric polymer preferably contains a unit of formula I (R1 is H or methyl; R2 , R5 are each a hydrocarbon; R3 , R4 are each H or a hydrocarbon; A is O or NH etc.). An especially preferable compound is expressed in formula II (R6 is H or methyl; R7 is a hydrocarbon; n and m are integers). A compound of formula III (R8 is a hydrocarbon; p is an integer) is preferred as the polyoxyalkylene alcohol ether. The cellulose ether containing the unit of formula IV (R9 to R11 are each a hydrocarbon etc.), is preferred.
The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnormal tyrosine kinase activities. The present invention also provides pharmaceutical compositions and methods for inhibiting cell proliferation of differentiation and related disorders. Examples of such disorders include cancers, blood vessel proliferative disorders, psoriasis, hyperimmune response and fibrotic disorders. Example ofother disorders include the HER2 disorders, EGF disorders, IGFR disorders, PDGFR disorders, met disorders, SrC disorders, and KDR/FLK-1 disorders described herein. It is to be understood that compounds which are effective for diseases related to one TK will also likely be effective for diseases related to other TK's, especially those from the same family. Thus, for example, compounds shown to have good effect against Her2 are likely to also have good effect against other members of the Her family, i.e., EGFR, Her3,and Her4.
BACKGROUND: Diabetes foot sepsis (DFS) is the leading cause of amputation of lower extremities. Over 50 % of patients who have had major lower extremity amputation due to DFS are dead within 4 years following the procedure.
AIM: To determine the life expectancy of patients following amputation for DFS at a regional hospital in South Africa.
METHODS: We conducted an audit of patients who had DFS and were admitted over a 5-year period. The duration from admission to time of death was recorded in days. Occurrence of death was confirmed from family members of the deceased using structured telephonic interview questionnaires. Categorical findings were summarized using actual counts and percentages and compared using either the Chi-square or Fisher's exact test. We used the mean with standard deviation or median and range to compare parametric and non-parametric continuous data, respectively. The Shapiro-Wilk test was used to test normality of data. Multivariate logistic regression was done to establish factors that were strongly associated with the mortalities. Adjusted survival curves were added to compare the rate of occurrence of mortality between males and females with age as a confounder. Statistical significance was set at a p-value below 0.05.
RESULTS: 197 were found of which 100 % of participants had Type 2 diabetes mellitus and 63.5 % were males. Associated comorbidities included hypertension in 73.6 %, obesity in 66 %, alcohol use in 64.5 % and smoking in 58.4 %. 190 participants had an amputation and 19.3 % died.
CONCLUSION: DFS was more common in males and 96 % of the patients had an amputation. Mortality rate within 4 years following amputation was 19.3 % and was higher in females and individuals with multiple comorbidities.
The invention belongs to the technical field of tea production and preparation, and discloses actinidia arguta leaf tea and a preparation method thereof, wherein mature actinidia arguta leaves are selected; freezing the fruits of the soft jujube at low temperature by utilizing a freeze-drying FD freeze-drying technology; dehydrating, drying, processing into tablet, and adding into folium Ziziphi Spinosae tea. The method adopts FD freeze-drying technology to dehydrate and dry the soft date fruits in a low-temperature freezing mode and then process the soft date fruits into slices. The tea is added into the soft jujube cotyledon tea, so that the color, aroma, taste and nutritional and medicinal values of the fresh tea are preserved to the maximum extent. And has good rehydration. Does not contain any additive, and is an ideal natural sanitary food. The frozen and dried soft jujube slices are added into soft jujube tea, so that the content of vitamin C is increased, and the soft jujube frozen and dried soft jujube slices have high antioxidation effect, and have the effects of scavenging free radicals, tonifying kidney, resisting cancer, expelling toxin, improving immunity and the like.
Methods and compositions are provided for the controlled release of an active agent. The composition includes an oligonucleotide scaffold and a substantially complementary oligonucleotide factor. An active agent is attached to the oligonucleotide factor. The two oligonucleotides are differentially degradable, so that degradation of the scaffold occurs a faster rate than the degradation of the factor. As the scaffold degrades, the factor is released. The active agent can be a therapeutic agent, or a diagnostic agent.
Formulations for oral transmucosal compositions including aromatase inhibitors (AIs) in combination with transmucosal absorption enhancers are disclosed. Oral transmucosal compositions can be for fast release or slow release, and can be administered to induce ovulation in a female patient and thereby reduce symptoms of anovulatory infertility, unexplained infertility, and the like. Oral transmucosal compositions include liquid dosage forms, solid dosage forms, and chewing gums. Further dosage forms include mucoadhesive thin strips, thin films, tablets, patches, and tapes, among others. Other dosage forms are: mucoadhesive liquids, such as, for example gel-forming liquid; gel-forming semisolids; and gel-forming powders, among other dosage forms that exhibit mucoadhesive properties, and provide oral transmucosal delivery of AIs. Oral transmucosal compositions will deliver AIs directly into the patient's bloodstream, and provide high bioavailability of AIs; therefore, the required doses are lower.
In this group, UC-MSC transplantation will be administered twice to each patient in the study group via the hepatic artery: the first transplantation will be performed post-surgery at the beginning, and the second one will be performed 6 months later, with a dose of 1 million UC-MSC/kg. The applications will be applied after kasai portoenterostomy.
Patients followed in Internal Medicine department bring together favorable conditions for the use of alternative medicines. While some are recognized for their benefits, some can, on the contrary, harm the patient. It is therefore proposed to make a complete descriptive inventory of these practices, through an anonymized questionnaire. The main objective is the evaluation of the proportion of the use of alternative medicines in patients with autoimmune diseases in the department of Internal Medicine .

At all times alternative medicine has existed. Internal Medicine deals with rare autoimmune diseases, of which there is not always a cure. Even when the treatment is optimal, there are often subjective complaints.Patients followed in Internal Medicine therefore have favorable conditions for the use of alternative medicines. While some are recognized for their benefits, some can, on the contrary, harm the patient. It is therefore proposed to make a complete descriptive inventory of these practices, through an anonymized questionnaire. This information will make it possible to target the patient's needs, and to be able to offer alternative medicines that are better focused, without calling into question their conventional treatment
Clean catch urine should be used due to possible vaginal secretion contamination with falsely elevated U Pr/Cr ratio. However, no supporting reference was found in the article and no control group with random urine collection for comparison to clean catch specimen U Pr/Cr was included in their study. The original studies that validated spot Pr/Cr urine as a predictor of 24 -hour total urine protein used random non-clean catch random urines . They had an r value of .93-.99 in estimating total protein excreted in 24 hours. At our institution we use Siemens-base test to determine U Pr/Cr. In the product insert the company states that no special patient preparation is necessary.

Thus, this study will determine the incidence of elevated U Pr/Cr in normal term pregnant women. In addition we will determine if a "clean catch" urine has an effect on the U Pr/Cr.
The invention discloses a degradable orthopedics drug carrier system with osteo inductivity and a preparation method thereof. The drug carrier system essentially consists of the carrier material which is biological activity glass setting solid and the carried therapeutic drug. And the carrier material is the solid body carrier material with certain strength which is obtained through the fast curing after the reaction of highly reactive boron-containing biological activity glass and cured buffer liquid after the reaction. The carrier material can carry various drugs without thermal stability restriction, such as antibiotics, bone growth factors, antituberculosis drugs, antineoplastic drugs, which are used for the treatment of orthopedics diseases, thus composing the integrated drug carrier system. The drug carrier system can degrade automatically under the function of human tissue fluid in a human body with a porous structure left during the degradation which provides diffusion channels for the sustainable releasing of the drugs, thus achieving the effect that the drugs are chronically and uniformly released. The drug carrier system has good biocompatibility, biological activity and osteo inductivity and can be applied to the treatment of various diseases of orthopedics.
PURPOSE:To easily execute and experience the pleasure of an aromatic body by placing a heating aromatic body constituted by using non-combustible inorg. particles as a heating medium and adding an aromatic material to said medium to mix the same therewith on a heat-resistant placing member, and heating said aromatic body through the heat-resistant placing member. CONSTITUTION:As a heating medium 1b, for example, a water-soluble substance such as potassium chloride, calcium chloride or sodium carbonate or a water- insoluble inorg. substance such as an ore or a natural stone is used. As an aromatic material 1a, for example, aloes wood, sandalwood or reiryoko (phonetic) are used. A heating aromatic body 1 formed by mixing the aromatic material 1a and the heating medium 1b is placed on a heat-resistant placing member 2 composed, for example, of a ceramic product or a metal non-combustible substance and a heating source 3 is arranged under said member 2 to heat the heating aromatic body 1 through the heat-resistant placing member 2. At first, the heating medium 1b absorbs heat to be heated and the aromatic material 1a is heated to begin to diffuse an arom. By this method, the pleasure of 'incense' not requiring subsidary etiquette such as sonorous manners and behavior of 'Kodo' can he enjoyed.
962,711. Coating particulate material. SMITH KLINE & FRENCH LABORATORIES. Aug. 30, 1962 [Sept. 18, 1961], No. 33415/62. Heading B2B. Fine solid particles are coated by forming a dense phase fluidized bed of the particles, continuously withdrawing particles from the lower portion of the fluidized bed, passing the withdrawn particles through a nozzle with a gas to deagglomerate them and eject them upwards into a coating zone, spraying the particles in said zone with a liquid coating material and directing the coated particles falling under gravity into the upper portion of the fluidized bed. As shown, apparatus for carrying out the process comprises an upstanding coating chamber 6 having an open lower end, means 104 for exhausting gas from the upper portion of the coating chamber, a casing 4 for containing solids having its upper end in communication with the lower end of the coating chamber, the lower portion of the casing having a decreasing cross-sectional area as it extends downwards, a powder nozzle 14, extending upwards within the casing from a point adjacent the inner periphery of the lower portion of the casing, gas supply means 50 for introducing a jet of gas into the casing, to supply a flow of gas between the casing and the powder nozzle so as to form when the apparatus is in use a fluidized bed of solid particles 24 within the casing and to entrain solid particles from the fluidized bed into the powder nozzle for spraying upwards into the coating chamber 61, and a spray nozzle 78 in the coating chamber adapted to spray a liquid coating material on to the solid particles. Particles of drugs, foodstuffs or chemicals may be sprayed with liquefied waxes.