anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Acute myocardial injury is associated with poor outcomes in patients with acute ischemic stroke, but its prognostic significance in patients with spontaneous intracerebral hemorrhage remains unclear. We investigated whether acute myocardial injury and the direction of the cardiac troponin I (cTnI) change (rising versus falling) affect post-intracerebral hemorrhage outcomes.
METHODS AND RESULTS: We re-analyzed the FAST (Factor-Seven-for-Acute-Hemorrhagic-Stroke) trial. Acute myocardial injury was defined as at least 1 cTnI value above the upper reference limit with a rise/fall of >20%. Logistic regression tested for associations (1) between acute myocardial injury (presence versus absence) and poor outcome (modified Rankin Scale 4-6) and mortality at 15 and 90 days; (2) among 3 groups (rising versus falling versus no acute myocardial injury) and outcomes. Among the 841 FAST participants, 785 patients were included. Acute myocardial injury was detected in 29% (n=227); 170 had rising cTnI. At 15 and 90 days, respectively, those with acute myocardial injury had higher odds of poor outcome (adjusted odds ratio) ([aOR] 2.3 [95% CI, 1.3-3.9]); and adjusted odds ratio 2.5 [95% CI, 1.6-3.9];, and higher odds of mortality (adjusted odds ratio 2.4 [95% CI, 1.4-4.3]; and adjusted odds ratio 2.2 [CI, 1.3-3.6]) than patients without. There was no interaction between FAST group assignment and myocardial injury, and associations between myocardial injury and outcomes were consistent across group assignments. Rising cTnI was associated with the highest risk of poor outcomes and mortality.
CONCLUSIONS: In this secondary analysis of the FAST trial, acute myocardial injury was common and associated with poor outcomes. The direction of the cTnI change might provide additional risk stratification after intracerebral hemorrhage.
In this group in the PROMOTE-II study, mothers receive 3 doses of sulfadoxine-pyrimethamine (SP), and children receive every 3 month dihydroartemisinin-piperaquine (DP). No intervention is given in the observational PROTECT study.
<P>PROBLEM TO BE SOLVED: To provide a tyrosinase activity inhibitor and a cosmetic.  <P>SOLUTION: The invention relates to a tyrosinase activity inhibitor containing a pine bark extract and a tea extract. Preferably, the pine bark extract contains ≥20 mass% OPC (oligomeric proanthocyanidin) and ≥5 mass% catechins and the tea extract contains ≥60 mass% catechins. More preferably, the tyrosinase activity inhibitor has a solid or solution form such as tablet, pill, capsule, granule, powder, powdery medicine or liquid medicine. The cosmetic containing the tyrosinase activity inhibitor preferably has the form of essence, face lotion, cosmetic cream, lotion, pack, ointment, milky lotion, cleansing foam, cleansing gel or soap.  <P>COPYRIGHT: (C)2009,JPO&INPIT
A two-component stomach ultrasonic examination contrast agent and a preparation method therefor, belonging to the technical field of medical imaging diagnosis. The contrast agent consists of two components: a component A, which consists of functionalized silicon dioxide particles, a defoaming agent, sodium alginate, citric acid and water; and a component B, which is a calcium chloride solution. During examination, the component A is used first. As the viscosity of the component A is low, gas can be rapidly displaced while the stomach is being filled, thus reducing gas artifact interference. At the same time, as gastric peristalsis occurs, the functionalized silicon dioxide particles are rapidly dispersed to the stomach wall and, under the action of an aldehyde group or a sulfhydryl group and a prolamin, adhere to a gastric wall lipoprotein layer, forming a uniform high-echo interface on the stomach wall, thereby improving the disease diagnosis rate. After the component A is used for 3 minutes, the component B is used. The viscosity of the contrast agent increases within 1-3 minutes, prolonging the examination window and ensuring ample examination time.
Prescribed dietary pattern. Energy largely from fat, cellular carbohydrate sources, and otherwise similar food types as in the acellular/cellular carbohydrate diets including at least 500 grams of fruits/vegetables per day.
Subjects will complete all study assessments without the aVNS. In the following visit, Auricular vagal nerve stimulation (aVNS) will be provided by a device that is placed around the ear. A low-voltage electrical signal will be given for 30 minutes. Participation will be up to 2 weeks.
High-temperature stress poses a significant environmental challenge for aquatic organisms, including tsinling lenok trout (Brachymystax lenok tsinlingensis). This study aimed to investigate the role of microRNAs (miRNAs) in inducing liver inflammation in tsinling lenok trout under high-temperature stress. Tsinling lenok trout were exposed to high-temperature conditions (24 °C) for 8 h, and liver samples were collected for analysis. Through small RNA sequencing, we identified differentially expressed miRNAs in the liver of high-temperature-stressed tsinling lenok trout compared to the control group (maintained at 16 °C). Several miRNAs, including novel-m0105-5p and miR-8159-x, showed significant changes in expression levels. Additionally, we conducted bioinformatics analysis to explore the potential target genes of these differentially expressed miRNAs. Our findings revealed that these miRNA target genes are involved in inflammatory response pathways, such as NFKB1 and MAP3K5. The downregulation of novel-m0105-5p and miR-8159-x in the liver of high-temperature-stressed tsinling lenok trout suggests their role in regulating liver inflammatory responses. To validate this, we performed a dual-luciferase reporter assay to confirm the regulatory relationship between miRNAs and target genes. Our results demonstrated that novel-m0105-5p and miR-8159-x enhance the inflammatory response of hepatocytes by promoting the expression of NFKB1 and MAP3K5, respectively. In conclusion, our study provides evidence that high-temperature stress induces liver inflammation in tsinling lenok trout through dysregulation of miRNAs. Understanding the molecular mechanisms underlying the inflammatory response in tsinling lenok trout under high-temperature stress is crucial for developing strategies to mitigate the negative impacts of environmental stressors on fish health and aquaculture production.
The WHT group includes only patients newly enrolled in the Geisinger MPP program who consent to participate in the study. WHT subjects will be recruited over 1 year, with 1 year of follow-up.
Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp80 was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmembrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Dimerization of the envelope precursors might be essential for the processing of these glycoproteins into the mature products extracellular and transmembrane glycoproteins. Furthermore the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
Vitrectomy to remove vitreous hemorrhage and take additional panretinal photocoagulation. If vitreous hemorrhage was not absorbed/vitreous hemorrhage aggravation/proliferation membrane formation/tractive retinal detachment after 4 weeks of observation, the treatment was considered failed and PPV was performed.
INTRODUCTION: There has been a paradigm shift in the treatment of chronic lymphocytic leukemia (CLL) over the past decade. With the advent of self-administered targeted oral anticancer agents (OAAs), the treatment of CLL has begun to shift from the infusion clinic to the patient's home. This introduced new challenges including patient non-adherence, class-specific adverse effects, and financial toxicity to treatment. In this paper, we discuss a structured approach to identifying and addressing barriers to optimal patient outcomes.
AREAS COVERED: We will ground our discussion using the five dimensions of adherence as defined by the World Health Organization (WHO): therapy factors, health-system factors, condition-related factors, social/economic factors, and patient factors. We discuss how each of these domains present in patients with CLL. We will also discuss how we can prevent and address these barriers in through the various phases of treatment.
EXPERT OPINION: A multidisciplinary program to support patients on OAAs is critical for patients with CLL. This team should involve pharmacists and social workers in addition to nursing, advanced practitioner and physician colleagues. The program should aim to identify, prevent, and address patient-specific barriers by offering individualized solutions. We describe how such a program can be designed and implemented.
PURPOSE:To obtain a liquid agent for external use having excellent permeability and retention in the corneum of nail and useful for the treatment of nail trichophytosis. CONSTITUTION:This composition for the treatment of nail trichophytosis contains omoconazole nitrate or butenafine hydrochloride as an active component compounded to a base agent composed of a hydrophobic film-forming agent such as nitrocellulose, alkyd resin and polyvinyl butyral and a solvent. The amounts of the components are preferably 0.3-5wt.% (preferably 0.5-3wt.%) of the active component, 3-35wt.% of the film-forming agent and 20-90wt.% of the solvent. A synergistic effect can be expected by adding <=20wt.% of an absorbefacient for nail (e.g. liquid higher alcohol, benzyl alcohol and salicylic acid). A film is formed by the application of this composition to the surface or the peripheral part of nail and the active component is impregnated from the coating film into the surface or inside of the nail.
Methods for increasing the effectiveness of one or more antimicrobial agents incorporated in polymeric films are described. The methods involve adding an antimicrobial agent promoter to the polymer prior to or when forming the film. The antimicrobial agent promoter is a blowing agent, a hydrophilic wetting agent, and/or both. Also described are polymeric films comprising antimicrobial agents and such promoters, and multilayer barrier assemblies using such films. The multilayer barrier assemblies find wide application in the medical field. Also described are multilayered polymeric films comprising a first skin layer that includes at least one gas and vapor barrier organic polymer, a core layer that comprises at least one elastomeric organic polymer, and a second skin layer that comprises at least one sealable organic polymer and at least one antimicrobial agent. Articles comprising the film are useful in various applications to include medical and health care applications. A method to provide a gas and vapor barrier and antimicrobial activity in an article comprises manufacturing an article in which the article comprises the film.
PURPOSE:A composition for exodermal administration, obtained by containing a prolinol ester to enhance the skin permeability and percutaneous absorbing action of a drug and further blending a polar substance to synergistically enhance the percutaneous absorbability. CONSTITUTION:A composition obtained by containing a prolinol ester expressed by formula I (Ra is H or aliphatic hydrocarbon residue; Rb is aliphatic hydrocarbon residue; Ra + Rb is <=18C) and having high percuteaneous absorbability of a drug, e.g. local aneasthetic, antibiotic substance, antihistaminic agent, etc. The compound expressed by formula I is further used together with a polar compound, e.g. cyclic urea expressed by formula II (R1 and R2 are H or lower alkyl), lower alcohol, glycerol, etc., to synergistically enhance skin permeability and percutaneous absorbing action of the drug. The compound expressed by formula I is preferably blended in an amount of 1-50wt% based on the total weight of the polar compound and the compound expressed by formula I.
Use of illegal drug among adolescents is one of the critical health problems in this age group. The purpose of that study was to apply the 3D virtual reality technology to develop a training program aiming at improving the abilities of problem solving, self-efficacy and teamwork of supervisory volunteers on adolescents' illegal drug use. This study used a randomized controlled design with recruiting 68 participants. The participants in the experimental group received the 3D VR training program and the counterparts in the control group did not receive any intervention. The participants in the experimental group performed better on problem solving, self-efficacy and teamwork. In addition, the scores of technology use related variables also supported that experimental participants favored the 3D VR training system. The findings suggested that the 3D VR training system enhanced the supporting volunteers' abilities to deal with adolescents' illegal drug use. The 3D VR program showed potential for future promotion to supporting volunteers that contribute to improve volunteers' abilities on dealing with adolescents' illegal drug use.
AIMS: Bariatric surgery results in rapid recovery of glucose control in subjects with type 2 diabetes mellitus. However, the underlying mechanisms are still largely unknown. The present study aims to clarify how bariatric surgery modifies pancreatic cell subgroup differentiation and transformation in the single-cell RNA level.
METHODS: Male, 8-week-old Zucker diabetic fatty (ZDF) rats with obesity and diabetes phenotypes were randomized into sleeve gastrectomy (Sleeve, n = 9), Roux-en-Y gastric bypass (RYGB, n = 9), and Sham (n = 7) groups. Two weeks after surgery, the pancreas specimen was further analyzed using single-cell RNA-sequencing technique.
RESULTS: Two weeks after surgery, compared to the Sham group, the metabolic parameters including fasting plasma glucose, plasma insulin, and oral glucose tolerance test values were dramatically improved after RYGB and Sleeve procedures (p < .05) as predicted. In addition, RYGB and Sleeve groups increased the proportion of pancreatic β cells and reduced the ratio of α cells. Two multiple hormone-expressing cells were identified, the Gcg+/Ppy + and Ins+/Gcg+/Ppy + cells. The pancreatic Ins+/Gcg+/Ppy + cells were defined for the first time, and further investigation indicates similarities with α and β cells, with unique gene expression patterns, which implies that pancreatic cell transdifferentiation occurs following bariatric surgery.
CONCLUSIONS: For the first time, using the single-cell transcriptome map of ZDF rats, we reported a comprehensive characterization of the heterogeneity and differentiation of pancreatic endocrinal cells after bariatric surgery, which may contribute to the underlying mechanisms. Further studies will be needed to elucidate these results.
Methods and systems for automatically scoring diagnoses associated with clinical images. One system includes a server including an electronic processor and an interface for communicating with at least one data source. The electronic processor is configured to receive a diagnosis associated with an image of a patient from the at least one data source over the interface. The diagnosis is for an anatomical structure represented in the image. The electronic processor is also configured to receive a pathology result for the patient for the anatomical structure generated after the diagnosis from the at least one pathology result source over the interface. The electronic processor is also configured to automatically generate a score based on a comparison of the diagnosis and the pathology result. The electronic processor is also configured to display the score within a graphical user interface.
PURPOSE:A cosmetic having improved hair tonic effect, and remedying effect on acne free from side effect, containing a 4-estren-3-one-17beta-carboxylic acid. CONSTITUTION:A cosmetic containing one or more 4-estren-3-one-17beta-carboxylic acids shown by the formula (R is H, or 1-5C alkyl). It is said that physiological symptom such as baldness, falling hair, seborrhea, acne, etc. is caused by increase in male hormone irritation resulting from excess accumulation of male hormone. The compound shown by the formula inhibits the linkage between 5alpha- dihydrotestosterone (5alpha-DHT for short), a main compound of male hormone, and a protein acceptor, further inhibits the activity of reductase to reduce testosterone into 5alpha-DHT, has improved hair tonic effect, and remedying effect of acne. It has no side effect unfavorable to hormone action at all.
Arm A: sodium chloride 1g/10kg of body weight /day per os on day -2 and -1 before contrast exposure. With a maximum dose of 10 gram sodium chloride a day.
The tolerability of Dexmedetomidine Injection was studied in one study in which healthy adult subjects were administered doses at and above the recommended dose of 0.2 to 0.7 mcg/kg/hr. 

The maximum blood concentration achieved in this study was approximately 13 times the upper boundary of the therapeutic range. The most notable effects observed in two subjects who achieved the highest doses were first degree atrioventricular block and second degree heart block. No hemodynamic compromise was noted with the atrioventricular block and the heart block resolved spontaneously within one minute. 

Five adult patients received an overdose of Dexmedetomidine Hydrochloride in the intensive care unit sedation studies. Two of these patients had no symptoms reported; one patient received a 2 mcg/kg loading dose over 10 minutes (twice the recommended loading dose) and one patient received a maintenance infusion of 0.8 mcg/kg/hr. Two other patients who received a 2 mcg/kg loading dose over 10 minutes, experienced bradycardia and/or hypotension. One patient who received a loading bolus dose of undiluted Dexmedetomidine Injection (19.4 mcg/kg), had cardiac arrest from which he was successfully resuscitated.
The chemical structure of piperidine has a unique ability to combine with other molecular fragments. This fact makes it possible to actively use it as an effective basis for the creation of new drug-like substances. Thus, the aim of the current investigation was to study the acute toxicity, local anesthetic potency, and antiarrhythmic activity of the two new synthesized piperidine derivatives under laboratory codes LAS-286 and LAS-294 (local anesthetic substances). The Bulbring & Wajda animal model and method of determining the nociception threshold during electrical stimulation was used to investigate the action of the substance during infiltration anesthesia. An antiarrhythmic activity was observed by the aconitine-induced rat arrhythmia model. Additionally, these compounds were studied in relation to molecular docking to delineate the structure-activity relationships. The tested piperidine derivatives had a low toxicity in the subcutaneous and intravenous administration routes. The experimental results showed a higher prolonged and pronounced local anesthetic activity for LAS-286 at a 0.5% concentration, compared to the reference preparations. The low dosage of 0.1 mg/kg of LAS-294 demonstrated a pronounced preventive antiarrhythmic effect in 90% of cases on the development of mixed arrhythmia, caused by aconitine. The results of molecular docking confirmed a higher binding affinity of the tested piperidines with the Nav1.4 and Nav1.5 macromolecules. The results of the present study are very promising, because these piperidines have shown a high biological activity, which can suggest a potential therapeutic application in the future.
Eligible patients will be approached for enrollment after their first night in the hospital (i.e.: not on day of admission). Patient/parent will be asked to complete a brief questionnaire describing the child's general sleep habits prior to admission. The parent and/or child will then be asked to complete a questionnaire describing sleep while in the hospital; this in-hospital sleep questionnaire will be obtained for 3 consecutive nights after enrollment, or until discharge, whichever is soonest. A subgroup of patients (between the ages of 5 and 18) will be invited to participate in an additional aspect of the study, where they wear an actigraph (a small device that looks like a watch) for up to 72 hours. This device reliably measures sleep by monitoring the child's motion. This will be used to relate sleep perception to more objective measures of sleep as provided by actigraphy.
A system, method, and computer program product for generating a virtual avatar representing a plurality of users. Sensor data is obtained from sensor sets associated with each user. A user performance metric can be determined for each user based on the corresponding sensor data. An avatar performance metric is generated based on the user performance metrics determined for the plurality of users. An avatar performance characteristic is then determined from the avatar performance metric. The avatar performance characteristic can be used to control the performance of a virtual avatar within a virtual environment. The virtual avatar can be animated and displayed within the virtual environment based on the avatar performance characteristic.
The group metacognitive training program (MCT) is fully documented (Moritz, Woodward, \& Metacognition Study Group, 2007; VanHam Campus Press) and can be obtained in more than 15 languages cost-free via the following link: www.uke.de/mkt. The group program is delivered to groups of 3-10 patients by trained psychologists addressing delusion-related metacognitive biases (e.g., jumping to conclusions). The eight modules are presented via a video projector using pdf-converted Power-Point slides. Each group session lasts approximately 45-60 minutes. Individualized MCT (MCT+) follows group sessions and accords to the general guidelines for cognitive-behavioral therapy. For each patient, 8 one-to-one sessions were carried in addition to one session relating to the medical history.