anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Hypoxia, a significant feature of the tumor microenvironment, is closely associated with tumor growth, metastasis, and drug resistance. In the field of tumor microenvironment analysis, accurately imaging and quantifying hypoxia - a critical factor associated with tumor progression, metastasis, and resistance to therapy - remains a significant challenge. Herein, a hypoxia-activated red-emission fluorescent probe, ODP, for in vivo imaging of hypoxia in the tumor microenvironment is presented. Among various imaging methods, optical imaging is particularly convenient due to its rapid response and high sensitivity. The ODP probe specifically targets nitroreductase (AzoR), an enzyme highly expressed in hypoxic cells, playing a vital role by catalyzing the cleavage of azo bonds. The optical properties of ODP exhibited excellent performance in terms of fluorescence enhancement, fluorescence lifetime (0.81 ns), and detection limit (0.86 µM) in response to SDT. Cell imaging experiments showed that ODP could effectively detect and image intracellular hypoxia and the imaging capability of ODP was studied under various conditions including cell migration, antioxidant treatment, and different incubation times. Through comprehensive in vitro and in vivo experiments, including cellular imaging and mouse tumor models, this work demonstrates the efficacy of ODP in accurately detecting and imaging hypoxia. Moreover, ODP's potential in inducing apoptosis in cancer cells offers a promising avenue for integrating diagnostic and therapeutic strategies in cancer treatment. This innovative approach not only contributes to the understanding and assessment of tumor hypoxia but also opens new possibilities for targeted cancer therapy.
NEW MATERIAL:A human hepatic parenchymal cell growth factor (hHGF), having an amino acid sequence on the N-terminal side expressed by the formula (Xaa is pyroglutamic acid residue) and a specific amino acid sequence. USE:A therapeutic agent for hepatopathy. PREPARATION:For example, a cDNA of a human hepatic parenchymal cell growth factor (hHGF) is prepared according to a well-known method, treated with a restriction enzyme, linked to a plasmid vector and then transduced into Escherichia coli. Transformation is carried out and the resultant transformant is cultured and proliferated to recover and purify the resultant plasmid DNA. The obtained plasmid DNA is subsequently treated with a restriction enzyme, bound to an expression vector and transduced into an animal cell such as CHO cell to perform transformation. The resultant transformed animal cell is then cultured to express the plasmid DNA. Thereby, the objective hHGF having the amino acid sequence at the N-terminal expressed by the formula and the specific amino acid sequence is obtained.
PROBLEM TO BE SOLVED: To provide a substance which has specific functions of preventing growing fat and of decreasing an accumulated fat in viscera and to provide the use thereof. SOLUTION: A substance which exists in natural lipids derived from a highly unsatd. oil or fat selected from fish oils and vegetable oils (e.g. linseed oil and shiso oil), is separated artificially from the lipids, and has a function of specifically enhancing the decoupled breathing (proton leak) of thermogenetic tissue cells [e.g. brown fat cells (BA) of mammals including humans]; an agent contg. the substance as the acting component and having functions of preventing growing fat (i.e., of inhibiting the fat accumulation in viscera) and of decreasing an accumulated fat in viscera; a food contg. the substance as the acting component and having functions of preventing growing fat (i.e., of inhibiting the fat accumulation in viscera) and of decreasing an accumulated fat in viscera;  and a feed contg. the substance as the acting component and having function of preventing growing fat (i.e., of inhibiting the fat accumulation in viscera) and of decreasing an accumulated fat in viscera are provided. The substance has a function for specifically enhancing the proton leak of thermogenetic tissue cells, such as brown fat cells (BA) in thermogenetic tissues such as brown cell tissues (BAT) in tissue cells of living bodies of mammals, etc., including humans.
BACKGROUND & AIMS: Butyric (one of the short-chain fatty acids), a major byproduct of the fermentation of non-digestible carbohydrates (e.g. fiber), is supposed to have anti-obesity and anti-inflammatory properties. However, butyrate's potential and mechanism in preventing obesity and the efficient form of administration remain to be clarified.
METHODS: Hence, we studied the effect of oral supplementation with 5% (w/w) sodium butyrate and 4% (w/w) β-glucan (fiber) on young male mice (C57BL/6J) with high-fat diet-induced obesity (HFD: 60 kcal% of fat + 1% of cholesterol). Six weeks old mice were fed diets based on HFD or control (AIN-93G) diet with/without supplements for 4 weeks. The unique, interdisciplinary approach combining several Raman-based techniques (including Raman microscopy and fiber optic Raman spectroscopy) and next-generation sequencing was used to ex vivo analyze various depots of the adipose tissue (white, brown, perivascular) and gut microbiome, respectively.
RESULTS: The findings demonstrate that sodium butyrate more effectively prevent the pathological increase in body weight caused by elevated saturated fatty acids influx linked to a HFD in comparison to β-glucan, thereby entirely inhibiting diet-induced obesity. Moreover, butyrate significantly affects the white adipose tissue (WAT) reducing the epididymal WAT mass in comparison to HFD without supplements, and decreasing lipid saturation in the epididymal WAT and perivascular adipose tissue of the thoracic aorta. Contrarily, β-glucan significantly changes the composition and diversity of the gut microbiome, reversing the HFD effect, but shows no effect on the epididymal WAT mass and therefore the weight gain inhibition is not as effective as with sodium butyrate.
CONCLUSIONS: Here, oral supplementation with sodium butyrate and β-glucan (fiber) has been proven to have an anti-obesity effect through two different targets. Administration-dependent effects that butyrate imposes on the adipose tissue (oral administration) and microbiome (fiber-derived) make it a promising candidate for the personalized treatment of obesity.
OBJECTIVE: The study was carried out to evaluate the role of the AST (Aspartate transaminase)/ALT (Alanine transaminase) ratio as an indicator of the functional severity in people with chronic heart failure (CHF) with reduced left ventricular ejection fraction.
METHODS: A prospective cross-sectional study was conducted in a tertiary care centre in South India among the individuals who had left ventricular ejection fraction (LVEF) of ≤40 %. The study period was between January 2021 and December 2021. Consecutive patients with the criteria were enrolled in the study. Study participants were grouped based on their AST/ALT ratio value (ratio<1 and ratio≥1).
RESULTS: In present study of 100 participants, there was a statistically significant difference between two groups with respect to ALT, AST/ALT ratio, and ALP (Alkaline phosphatase). There was a significant correlation between the APRI (AST to platelet ratio index) and FIB-4 (Fibrosis-4) with AST/ALT ratio. Diagnostic analysis of AST/ALT ratio to predict the severity of CHF with reduced EF, the area under the curve (AUC) was 0.547 (p-value = 0.5654) with a 95 % confidence interval of 0.299-0.795 with an optimal cut-off value of 0.6, sensitivity of 96.70 %, and specificity of 33.33 %.
CONCLUSION: The AST/ALT ratio is increased in patients with CHF patients with reduced left ventricular ejection fraction. It is a simple predictor of left ventricular dysfunction in patients with heart failure with reduced ejection fraction.
Compositions of hydroxyl-terminated dendrimers covalently conjugated with functional nucleic acids (D-FNA) to prevent, treat or diagnose one or more diseases or disorders in a subject in need thereof, and methods of use thereof, have been developed. Covalent conjugation of FNA to dendrimer greatly enhances serum half-life and bioavailability, protecting the payload from protein adsorption and enzymatic degradation. Preferably, the functional nucleic acids are covalently conjugated to dendrimers by functionally releasable coupling elements for intracellular release of FNAs within activated macrophages, including tumor-associated microglia (TAMs). An exemplary functionally releasable coupling element is a glutathione-sensitive coupling element. Exemplary FNAs include antisense RNAs, microRNAs and silencing RNAs. The compositions are particularly suited for treating or ameliorating symptoms of inflammatory diseases and proliferative diseases. Methods of treating a human subject having or at risk of inflammatory diseases and proliferative diseases are provided.
Embodiments of the present disclosure relate to collaborative AI with respect to privacy-assured transactional data. A data intersection of data to be used between at least two participants is evaluated. The data will be used in Artificial Intelligence (AI) applications. An estimate of an instruction set required by the AI application is performed, wherein the estimate creates a modified instruction set in which operands are symbolically associated with corresponding privacy levels. Using the evaluated data intersection and the modified instruction set, a mapping is created from the data to the operands having the associated privacy metrics. The mapping processes overlapping data from the evaluated data intersection differently than non-overlapping data to improve privacy relative to the case without the mapping. The AI application is executed using the data to produce at least one parameter of the AI application. At least one parameter is output for use by a trained version of the AI application. Apparatus, methods, and computer program products are described.
OBJECTIVE: This systematic review and meta-analysis aimed to investigate the effects of herbal treatments on cervicovaginal human papillomavirus infection.
METHODS: A comprehensive literature search was conducted in PubMed, Scopus, Science Direct, and the Cochrane Library until December 2023, following Cochrane guidelines. Data were analyzed using the Review Manager computer program (Version 5.4.1).
RESULTS: Five randomized controlled trials involving a total sample size of 662 women were included in the study. The pooled odds ratio for individuals testing negative for human papillomavirus after herbal intervention among human papillomavirus-positive patients was 1.86 (95% confidence interval (CI) 0.64-5.43), according to the fixed-effects model. Three out of the five studies indicated a significant relationship. The relationship between positive human papillomavirus infection and herbal treatments, measured by the fixed-effects model, resulted in a pooled odds ratio of 0.41 (95%CI 0.17-1.01), reporting a significant association (p=0.05). Subgroup analysis revealed a significant reduction in the relationship between herbal treatment and atypical squamous cells of undetermined significance (OR 0.16, 95%CI 0.03-0.88, p=0.04) but no significant impact on the relationship between herbal treatment and low-grade squamous intraepithelial lesion (OR 0.33, 95%CI 0.01-8.77, p=0.51).
CONCLUSION: The meta-analysis suggests that herbal treatments reduce human papillomavirus infections. While herbal treatments show a significant reduction in atypical squamous cells of undetermined significance, they do not significantly impact the regression of low-grade squamous intraepithelial lesions.
The invention discloses a pharmaceutical composition for treating oyster velar virus, which comprises the following traditional Chinese medicines in parts by weight: 20-30 parts of cinnamon, 15-30 parts of indico naturalis, 2-10 parts of cornel, 15-25 parts of self-heal, 2-10 parts of Fructus Forsythiae and 10-20 parts of garlic. The invention also discloses a preparation method of the pharmaceutical composition. The content of the effective component cassia oil in the cinnamon is 1.4%, and the maximum conversion rate is up to 93.3%. The effective components of the indico naturalis are indirubin and indigotin, wherein the maximum conversion rate of the indirubin is up to 96.8%, and the maximum conversion rate of the indigotin is up to 96.1%. The pharmaceutical composition has better effect on treating oyster velar virus than the traditional western medicine or Chinese and western combined medicine, and the cure rate is up to 100%. The pharmaceutical composition composed of pure traditional Chinese medicine components does not have toxic or side effect on the oysters, and has the advantages of no dependency, high cure rate and no relapse.
Abstract This description provides cooling compositions that deliver a prolonged physiological 5 cooling sensation to the skin or a mucous membrane. The cooling compositions may be present alone or in product such as a chewing gum or a confection. The cooling compositions comprise a menthyl ester and a second cooling agent, which may be WS 3 or WS-23 and optionally Menthol. The menthyl ester may be a menthyl glutarate or a menthyl succinate ester, and it may be present in an amount of at least 5 weight 10 percentage, at least 10 weight percentage, at least 20 weight percentage, at least 30 weight percentage, or at least 40 weight percentage. In many instances, the menthyl ester is present in an amount of 5 to 60 weight percentage or especially 15 to 50 wt %. 3090947_1 (GHMatters} P77183.AU.3
BACKGROUND AND AIMS: Scirrhous HCC (SHCC) is one of the unique subtypes of HCC, characterized by abundant fibrous stroma in the tumor microenvironment. However, the molecular traits of SHCC remain unclear, which is essential to develop specialized therapeutic approaches for SHCC.
APPROACH AND RESULTS: We presented an integrative analysis containing single-cell RNA-sequencing, whole-exome sequencing, and bulk RNA-sequencing in SHCC and usual HCC samples from 134 patients to delineate genomic features, transcriptomic profiles, and stromal immune microenvironment of SHCC. Multiplexed immunofluorescence staining, flow cytometry, and functional experiments were performed for validation. Here, we identified SHCC presented with less genomic heterogeneity while possessing a unique transcriptomic profile different from usual HCC. Insulin-like growth factor 2 was significantly upregulated in SHCC tumor cells compared to usual HCC, and could serve as a potential diagnostic biomarker for SHCC. Significant tumor stromal remodeling and hypoxia were observed in SHCC with enrichment of matrix cancer-associated fibroblasts and upregulation of hypoxic pathways. Insulin-like growth factor 2 was identified as a key mediator in shaping the hypoxic stromal microenvironment of SHCC. Under this microenvironment, SHCC exhibited an immunosuppressive niche correlated to enhanced VEGFA signaling activity, where CD4 + T cells and CD8 + T cells were dysfunctional. Furthermore, we found that another hypoxic-related molecule SPP1 from SHCC tumor cells suppressed the function of dendritic cells via the SPP1-CD44 axis, which also probably hindered the activation of T cells.
CONCLUSION: We uncovered the genomic characteristics of SHCC, and revealed a hypoxia-driven tumor stroma remodeling and immunosuppressive microenvironment in SHCC.
This study will be a randomized controlled trial. This study will be conducted in cardiac surgery department at Faisalabad institute of cardiology. sample size will be 44including both male and female. Non- probability purposive sampling technique will be used.

Modified healthy heart questionnaire will be used as a screening tool. Baseline, postoperatively before discharge at week 5 assessment will be done by 6-minute walk test. Subjects in group A (interventional group) will be treated using segmental breathing exercises combined with Conventional Treatment (deep breathing exercise ) and the group B (control group) will be treated with only conventional treatment. Group-A (interventional group) will receive segmental breathing exercises for one month 5 days a week and 2 sessions per day for 15 minutes for each patient. conventional treatment will be for one month 5 days a week 10 to 15 repetitions of deep breathing exercise 2times a day. Dyspnea will be checked baselineand at week5 by modified Borg scale.Sputum cup was used for expectoration of sputum . Quality of life will be checked baseline and at week 5by SF-12 Questionnaire. Outcome variables will be 6MWT, dyspnea, quality of life, oxygen saturation, heart rate, blood pressure and expectoration of sputum. Data will be analyzed on SPSS-25.
The present invention relates to a preparation of dragonfly and male silkworm moth, which can be a wine, an oral liquid or a capsule. The present invention provides a preparation using dragonfly and silkworm moth as principal raw materials. The medicinal effects of the dragonfly and the male silkworm moth are further exerted, and simultaneously, the species of the adopted medicinal insects are properly enlarged. A small quantity of traditional Chinese medicine can also be matched as raw materials for preparing the preparation. The used medicinal insects with the mixture ratio are: 1% to 53% of dragonfly, 1% to 49% of male silkworm moth and 0.5% to 51% of aspongopus, and a small quantity of traditional Chinese medicine sea horse, angelica, radix paeoniae alba and matrimony vine can be properly added. The present invention has the health care efficiency of essence replenishment, marrow supply, kidney replenishment, yang strengthening, human body immune function enhancement, impotence treatment, premature ejaculation treatment, renal deficiency treatment, lumbago treatment, sexual function decline treatment, life lengthening, etc. without toxic or side effect.
Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound-triggered sonosensitizers. N-type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti-tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx, the sonodynamic therapy efficiency of TiO2 can be improved. Compared to conventional techniques, the high controllability of ALD allows for the delicate loading of CoOx nanoparticles into TiO2 pores, resulting in the precise tuning of the interfaces and energy band structures and ultimately optimal SDT properties. In addition, CoOx exhibits a cascade of H2O2→O2→·O2 - in response to the tumor microenvironment, which not only mitigates hypoxia during the SDT process, but also contributes to the effect of chemodynamic therapy (CDT). Correspondingly, the synergistic CDT/SDT treatment is successful in inhibiting tumor growth. Thus, ALD provides new avenues for catalytic tumor therapy and other pharmaceutical applications.
Placebo will be administered as a 1-hour intravenous infusion every 3 weeks + BSC. Participants who do not respond to placebo during the blinded treatment period will have option to crossover and receive siltuximab 11 mg/kg which will be administered by 1-hour intravenous infusion every 3 weeks + BSC during the unblinded treatment period.
A solid surfactant cosmetic composition includes (i) insoluble vegetable fibre, insoluble fruit fibre or mixture thereof; (ii) surfactant; and (iii) hydrocolloid. The solid surfactant cosmetic composition is prepared by dehydrating a liquid composition. The liquid composition includes (i) a vegetable pulp containing insoluble vegetable fibre, a fruit pulp containing insoluble fruit fibre or a mixture thereof, wherein the vegetable pulp, fruit pulp or mixture thereof is in an amount of 55 to 99 wt. %; (ii) surfactant in an amount of 0.9 to 40 wt. %; and (iii) hydrocolloid in an amount of 0.1 to 15 wt. %, the amounts being based on the total combined amount of pulp, surfactant and hydrocolloid.
Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well as in oral premalignant lesions, where they exert pro-tumorigenic activities. Since the two bacteria are present also in endodontic diseases, playing a role in their pathogenesis, here we analyze the literature searching for information on the impact that endodontic infection by P. gingivalis or F. nucleatum could have on cellular and molecular events involved in oral carcinogenesis. Results from the reviewed papers indicate that infection by P. gingivalis and/or F. nucleatum triggers the production of inflammatory cytokines and growth factors in dental pulp cells or periodontal cells, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. In addition, the two bacteria and the cytokines they induce halt the differentiation and stimulate the proliferation and invasion of stem cells populating the dental pulp or the periodontium. Although most of the literature confutes the possibility that bacteria-induced endodontic inflammatory diseases could impact on oral carcinogenesis, the papers we have analyzed and discussed herein recommend further investigations on this topic.
Dyschromic hypertrophic scar (HTS) is a common sequelae of burn injury, however, its mechanism has not been elucidated. This work is a histological study of these scars with a focus on rete ridges. Rete ridges are important for normal skin physiology, and their absence or presence may hold mechanistic significance in post-burn HTS dyschromia. It was posited that hyper-, and hypo-pigmented areas of scars have different numbers of rete ridges. Subjects with dyschromic burn hypertrophic scar were prospectively enrolled (n = 44). Punch biopsies of hyper-, hypo-, and normally pigmented scar and skin were collected. Biopsies were paraffin embedded, sectioned, stained with H&E, and imaged. The number of rete ridges were investigated. Burn hypertrophic scars that healed without autografts were first investigated. The number of rete ridges was higher in normal skin compared to HTS that was either hypo- (p < 0.01) or hyper-pigmented (p < 0.001). This difference was similar despite scar pigmentation phenotype (p = 0.8687). Autografted hyper-pigmented scars had higher rete ridge ratio compared to non-autografted hyper-pigmented HTS (p < 0.0001). Burn hypertrophihc scars have fewer rete ridges than normal skin. This finding may explain the decreased epidermal adherence to underlying dermis associated with hypertrophic scars. Though, contrary to our hypothesis, no direct link between the extent of dyschromia and rete ridge quantity was observed, the differences in normal skin and hypertrophic scar may lead to further understanding of dyschromic scars.
The use of ONZETRA Xsail is contraindicated in patients with ischemic or vasospastic CAD. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of sumatriptan. Some of these reactions occurred in patients without known CAD. 5-HT1 agonists, including ONZETRA Xsail, may cause coronary artery vasospasm (Prinzmetal's angina), even in patients without a history of CAD. 

Perform a cardiovascular evaluation in triptan-naïve patients who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) prior to receiving ONZETRA Xsail. If there is evidence of CAD or coronary artery vasospasm, ONZETRA Xsail is contraindicated. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of ONZETRA Xsail in a medically supervised setting and performing an electrocardiogram (ECG) immediately following administration of ONZETRA Xsail. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of ONZETRA Xsail.