anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a strong loquat syrup and its preparation method, seven kinds of Chinese medicinal materials such as folium Eriobotryae, except menthol, other six kinds of Chinese medicinal materials such as folium Eriobotryae, etc. decoct with water twice, 2 hours each time, mix the decoction, filter, concentrate to the relative density of the liquid medicine 1.13-1.15, add 2g of stevia rebaudiana essence to dissolve, add 0.5g of citric acid, dissolve right amount of essence and menthol with ethanol, stir, mix, stand, filter, add water to 1000ml, mix, get final product. The invention has the following advantages: 1. the weight of the pharmaceutical excipient can be reduced. 2. High dissolving speed and high stability to heat and acid. 3. The prepared medicine is not easy to ferment and expand, and overcomes the defects that the syrup can inhibit bacteria only at high concentration, and the syrup is easy to cause bacteria growth and expansion when the sugar concentration is reduced. 4. The steviosin can be used as health sugar for long term administration, has no adverse effect on human body, and is especially suitable for patients with cardiovascular diseases, obesity, and diabetes.
Infants that are spontaneously breathing with a normal heart rate will be randomized to receive prophylactic surfactant (Curosurf 2.5 mL/kg, based on estimated fetal weight) by the LISA procedure in the first 2 hours of life, using a conventional or video laryngoscope and a small flexible 16 gauge angiocatheter. Any repeat dosing for surfactant will be based on clinical indication at the physician discretion by the conventional endotracheal approach.
Postoperative pulmonary complications are known to increase the length of hospital stay and healthcare cost. One of the most serious form of these complications is postoperative respiratory failure, which is also associated with morbidity and mortality. A lot of risk stratification models have been developed for identifying patients at increased risk of postoperative respiratory failure. However, these models were built by using a traditional logistic regression analysis. A logistic regression analysis had disadvantages of assuming the relationship between dependent and independent variables as linear. Recent advances in artificial intelligence make it possible to manage and analyze big data. Prediction model using a machine learning technique and large-scale data can improve the accuracy of prediction performance than those of previous models using traditional statistics. Furthermore, a machine learning technique may be a useful adjuvant tool in making clinical decisions or real-time prediction if it is integrated into the healthcare system. However, to our knowledge, there was no study investigating the predictive factors of postoperative respiratory failure using a machine-learning approach. Therefore, the main objective of this study is to develop a machine learning model that predicts postoperative respiratory failure within 7 postoperative day using a real-world, local preoperative and intraoperative electronic health records, not administrative codes and evaluate its performance prospectively.
Placebo infusion, matched to infliximab will be given intravenously at Week 0, 2 and 6. At Week 10, 12 and 16, participants will receive 5 mg/kg infliximab intravenously. Placebo infusion will be again given at Week 14 and 22. Total duration of treatment will be 26 weeks.
PURPOSE:To obtain a gelatinous composition, containing a semisolid fatty or oily substance, low-molecular cyclic silicone and gelling agent without causing stickiness in use and suitable as a dermal and cosmetic ointment base without crystallizing the fatty or oily substance and increase of crystals even in preservation for a long period. CONSTITUTION:A gelatinous composition containing (A) 10-90wt.% blend of a semisolid fatty or oily substance which is preferably a solid at ordinary temperature, (e.g. vaseline or lanolin) with fatty or oily substance which is a liquid at ordinary temperature (e.g. liquid paraffin or vegetable oil), (B) 90-10wt.% low-molecular cyclic silicone, e.g. octamethylcyclotetrasiloxane or decamethylcyclopentasiloxane, and (C) 1-10wt.% gelling agent, e.g. dextrin ester of a fatty acid, cellulosic derivative or phospholipid. The ratio of the ingredients (A) to (B) is preferably within the range of 55-65:45-35. Various drug effective ingredients used as a drug fro external use can be blended in the above-mentioned composition.
Subjects will be drawn from refractory mesial temporal lobe epilepsy patients determined to be candidates for LITT. During their LITT surgery, in addition to the placement of the stereotactic LITT probe, subjects will receive a second smaller stereotactic electrode for intraoperative monitoring of epileptic discharges before and after surgery. After surgery, at regularly scheduled follow-ups, patients will receive a QOLIE-31-P questionnaire, in addition to standard post-operative care.
Helicobacter pylori (H.pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathology, especially non-cardiac gastric cancer. Strong evidence supports that H.pylori eradication is an effective approach to reduce the incidence of those pathological processes. Antimicrobial susceptibility test can pick out sensitive drugs to kill Helicobacter pylori, and reduce secondary drug resistance. But, there is a lack of high quality RCT to compare its efficacy with empirical regimen in the rescue treatment.

This study aims to assess the efficacy of 14-day antimicrobial susceptibility test guided quadruple therapy for the rescue treatment of Helicobacter pylori infection. Comparing this regimen with 14-day personal Medication History guided therapy to tell which one is better in clinic practice. Alterations in H.pylori assosicated dyspepsia and safety outcomes will also be evaluated.
Chikungunya is rapidly spreading throughout the Americas and causes debilitating chronic arthritis in approximately one fourth of patients. There is currently no standard treatment for chikungunya arthritis, and the mechanisms leading to this chronic arthritis are unclear. Further characterization of the disease pathophysiology is needed in order to guide evaluation of potential therapeutics. It is hypothesized that chronic chikungunya arthritis is due to persistence of active virus in the synovial fluid where macrophages serve as a viral reservoir. The predominance of activated macrophages in persistently infected tissue and the presence of viral genome within these macrophages in non-human primates makes our hypothesis plausible. To test this hypothesis, this study has three Specific Aims. Aim 1, describe host characteristics affect susceptibility to severe or persistent arthritis. Aim 2, determine if chikungunya virus persists in synovial fluid and synovial fluid macrophages in humans as shown in non-human primates. Aim 3, investigate how these macrophages may be activated and modulated by cytokines. To date, these pathophysiologic factors have not been well characterized in humans. Information gained from this study can directly lead to recommendations for the further evaluation of antiviral versus immune modulating medications.
Alhagi honey is derived from the secretory granules of Alhagi pseudoalhagi Desv., a leguminous plant commonly known as camelthorn. Modern medical research has demonstrated that the extract of Alhagi honey possesses regulatory properties for the gastrointestinal tract and immune system, as well as exerts anti-tumor, anti-oxidative, anti-inflammatory, anti-bacterial, and hepatoprotective effects. The aim of this study was to isolate and purify oligosaccharide monomers (referred to as Mel) from camelthorn and elucidate their structural characteristics. Subsequently, the impact of Mel on liver injury induced by carbon tetrachloride (CCl4) in mice was investigated. The analysis identified the isolated oligosaccharide monomer (α-D-Glcp-(1 → 3)-β-D-Fruf-(2 → 1)-α-D-Glcp), with the molecular formula C18H32O16. In a mouse model of CCl4-induced liver fibrosis, Mel demonstrated significant therapeutic effects by attenuating the development of fibrosis. Moreover, it enhanced anti-oxidant enzyme activity (glutathione peroxidase and superoxide dismutase) in liver tissues, thereby reducing oxidative stress markers (malondialdehyde and reactive oxygen species). Mel also improved serum albumin levels, lowered liver enzyme activities (aspartate aminotransferase and alanine aminotransferase), and decreased inflammatory factors (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6). Immunohistochemistry, immunofluorescence, and western blotting analyses confirmed the ability of Mel to downregulate hepatic stellate cell-specific markers (collagen type I alpha 1 chain, alpha-smooth muscle actin, transforming growth factor-beta 1. Non-targeted metabolomics analysis revealed the influence of Mel on metabolic pathways related to glutathione, niacin, pyrimidine, butyric acid, and amino acids. In conclusion, the results of our study highlight the promising potential of Mel, derived from Alhagi honey, as a viable candidate drug for treating liver fibrosis. This discovery offers a potentially advantageous option for individuals seeking natural and effective means to promote liver health.
Defects of human trophoblast cells may induce miscarriage (abnormal early embryo loss), which is generally regulated by lncRNAs. Ferroptosis is a newly identified iron-dependent programmed cell death. Hypoxia is an important and unavoidable feature in mammalian cells. However, whether hypoxia might induce trophoblast cell ferroptosis and then induce miscarriage, as well as regulated by a lncRNA, was completely unknown. In this work, we discovered at the first time that hypoxia could result in ferroptosis of human trophoblast cells and then induce miscarriage. We also identified a novel lncRNA (lnc-HZ06) that simultaneously regulated hypoxia (indicated by HIF1α protein), ferroptosis, and miscarriage. In mechanism, HIF1α-SUMO, instead of HIF1α itself, primarily acted as a transcription factor to promote the transcription of NCOA4 (ferroptosis indicator) in hypoxic trophoblast cells. Lnc-HZ06 promoted the SUMOylation of HIF1α by suppressing SENP1-mediated deSUMOylation. HIF1α-SUMO also acted as a transcription factor to promote lnc-HZ06 transcription. Thus, both lnc-HZ06 and HIF1α-SUMO formed a positive auto-regulatory feedback loop. This loop was up-regulated in hypoxic trophoblast cells, in RM villous tissues, and in placental tissues of hypoxia-treated mice, which further induced ferroptosis and miscarriage by up-regulating HIF1α-SUMO-mediated NCOA4 transcription. Furthermore, knockdown of either murine lnc-hz06 or Ncoa4 could efficiently suppress ferroptosis and alleviate miscarriage in hypoxic mouse model. Taken together, this study provided new insights in understanding the regulatory roles of lnc-HZ06/HIF1α-SUMO/NCOA4 axis among hypoxia, ferroptosis, and miscarriage, and also offered an effective approach for treatment against miscarriage.
Patients receive gemcitabine IV over 30 minutes followed by leucovorin calcium IV and fluorouracil IV over 5-10 minutes on days 1, 8, and 15. Treatment repeats every 4 weeks for a minimum of 2 courses in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months for 1 year and then every 6 months for 4 years.
The composition contains an active deodorant or antiperspirant base and a perfuming base in the form of an aqueous emulsion or in microencapsulated form, the perfuming base being combined with a film-forming agent and an emulsifying agent. The film-forming agent contains either chiefly polyvinylpyrrolidone, or a mixture of the latter with one or more compounds chosen from polyvinyl acetate, polyvinyl alcohol, dextrins, natural or modified starch, vegetable gums, pectins, xanthans, carboxymethylcellulose, methylcellulose, hydroxyethylcellulose and lipoheteropolysaccharides. The emulsifying agent is chosen from fatty acid mono- or diglycerides, esters derived from the combination of fatty acids with sorbitol or a saccharide, or their alkoxylated derivatives, or a tartaric, citric, ascorbic or lactic acid ester. The abovementioned composition has the advantage of releasing the volatile constituent of the fragrance at the desired time through the action of a source of moisture, especially sweat. It has, in addition, the advantage of giving rise to a re-encapsulation in situ, for example on the skin itself, of active constituents in the drying phase. It is especially suitable for the manufacture of articles intended for body care, such as deodorants and antiperspirants, produced in the form of sticks, roll-on devices, smooth-on devices or aerosols and pressure atomisers.
Blood loss and postoperative morbidity following adenotonsillectomy in children can be significant. The current technique for performing a tonsillectomy is "cold steel tonsillectomy" with electocautery hemostasis and a newer technique of coblation tonsillectomy. Postoperative pain has been shown to be increased in patients undergoing extensive electrocautery, with less pain seen in patients undergoing coblation tonsillectomy. The purpose of the study is to evaluate the clinical efficacy and complications of Floseal matrix hemostatic sealant for use in patients undergoing adenotonsillectomy compared with two other currently used techniques.

The study is a prospective, controlled clinical trial comparing Floseal hemostasis in "cold steel" knife dissection tonsillectomy with cautery hemostasis in "cold steel" knife dissection tonsillectomy and coblation tonsillectomy in a pediatric population. All children under the age of 18 without previous documented coagulopathy scheduled to undergo tonsillectomy will be offered enrollment in the study. Informed consent will be obtained from the patient's legal guardian. The goal of this study is to determine if Floseal reduces intraoperative blood loss, time to hemostasis, and postoperative morbidity in patients undergoing tonsillectomy compared with two other commonly used methods. Also, we wish to evaluate the complication rates following Floseal administration compared to those of electrocautery and coblation.
Limited information is available regarding the association between preoperative lung function and postoperative pulmonary complications (PPCs) in patients with esophageal cancer who undergo esophagectomy. This is a retrospective cohort study. Patients were classified into low and high lung function groups by the cutoff of the lowest fifth quintile of forced expiratory volume in 1 s (FEV1) %predicted (%pred) and diffusing capacity of the carbon monoxide (DLco) %pred. The PPCs compromised of atelectasis requiring bronchoscopic intervention, pneumonia, and acute lung injury/acute respiratory distress syndrome. Modified multivariable-adjusted Poisson regression model using robust error variances and inverse probability treatment weighting (IPTW) were used to assess the relative risk (RR) for the PPCs. A joint effect model considered FEV1%pred and DLco %pred together for the estimation of RR for the PPCs. Of 810 patients with esophageal cancer who underwent esophagectomy, 159 (19.6%) developed PPCs. The adjusted RR for PPCs in the low FEV1 group relative to high FEV1 group was 1.48 (95% confidence interval [CI] = 1.09-2.00) and 1.98 (95% CI = 1.46-2.68) in the low DLco group relative to the high DLco group. A joint effect model showed adjusted RR of PPCs was highest in patients with low DLco and low FEV1 followed by low DLco and high FEV1, high DLco and low FEV1, and high DLco and high FEV1 (Reference). Results were consistent with the IPTW. Reduced preoperative lung function (FEV1 and DLco) is associated with post-esophagectomy PPCs. The risk was further strengthened when both values decreased together.
The invention belongs to the field of daily-use chemicals and specifically relates to a bactericidal skin-care hand sanitizer and its preparation method. The bactericidal skin-care hand sanitizer comprises the following raw materials, by weight, 18-26 parts of Smilax glabra, 10-14 parts of glutinous rehmannia, 5-10 parts of senecio, 10-15 parts of alga oligosaccharides, 15-20 parts of polyvinyl alcohol, 8-14 parts of citric acid, 0.5-0.9 part of cananga oil, 5-9 parts of lauryl diethanol amide, 5-10 parts of licoflavone, 18-25 parts of ethanol and 30-50 parts of water. The hand sanitizer has an excellent cleaning effect. Hand cleaning rate of the hand sanitizer can reach up to more than 95%, and kill ratio of killing bacteria on the surface of skin can reach 100%. The hand sanitizer can effectively nurse hand skin, can supplement moisture for hand skin, makes hand skin white, tender and soft, has an anti-wrinkling effect and can effectively relieve false wrinkles of the hand. The hand sanitizer has stable performance. The preparation method is simple and easy to operate and is suitable for large-scale popularization and application.
The invention discloses a traditional Chinese medicine for treating cervical spondylosis. The traditional Chinese medicine comprises the following components in percentage by weight: 10.4-12.4% of notopterygium roots, 10.4-12.4% of radix astragali preparata, 8-10% of divaricate saposhnikovia root, 8-10% of angelica sinensis, 8-10% of red paeony roots, 8-10% of white paeony roots, 8-10% of rhizome Chuanxiong, 8-10% of zedoary, 4-5% of ephedra, 4-5% of ginger, 6-8% of cassia twig and 6.5-8.5% of hematoxylon. The traditional Chinese medicine can be orally taken after being decocted with water; and the traditional Chinese medicine can also be smashed by using a conventional method, sieved by using a 200-mesh sieve and subpackaged into 1# capsules the weight of each of which is about 1g. The capsules are orally taken. Through many-year clinical application, 166 patients taking the traditional Chinese medicine are counted, wherein the traditional Chinese medicine is capable of curing 120 patients, remarkable in curative effect for 28 patients, effective for 16 patients and invalid for 2 patients and has the total effective rate of 98.8%. The traditional Chinese medicine has no any toxic and side effects and no drug dependence and is simple in formula, convenient to take, low in cost, good in curative effect and high in effective rate.
BACKGROUND: Acute bronchiolitis, the most common lower respiratory tract infection in infants, is mostly caused by respiratory viruses. However, antibiotics are prescribed to about 25% of children with acute bronchiolitis. This inappropriate use of antibiotics for viral infections induces antibiotic resistance. This study aimed to determine the antibiotic prescription rate and the factors associated with antibiotic use in children with acute bronchiolitis in Korea, where antibiotic use and resistance rates are high.
METHODS: Healthcare data of children aged < 24 months who were diagnosed with acute bronchiolitis between 2016 and 2019 were acquired from the National Health Insurance system reimbursement claims data. Antibiotic prescription rates and associated factors were evaluated.
RESULTS: A total of 3,638,424 visits were analyzed. The antibiotic prescription rate was 51.8%, which decreased over time (P < 0.001). In the multivariate analysis, toddlers (vs. infants), non-capital areas (vs. capital areas), primary clinics and non-tertiary hospitals (vs. tertiary hospitals), inpatients (vs. outpatients), and non-pediatricians (vs. pediatricians) showed a significant association with antibiotic prescription (P < 0.001). Fourteen cities and provinces in the non-capital area exhibited a wide range of antibiotic prescription rates ranging from 41.2% to 65.4%, and five (35.7%) of them showed lower antibiotic prescription rates than that of the capital area.
CONCLUSION: In Korea, the high antibiotic prescription rates for acute bronchiolitis varied by patient age, region, medical facility type, clinical setting, and physician specialty. These factors should be considered when establishing strategies to promote appropriate antibiotic use.
Provided is a method for producing: a pyridazinone derivative and/or a pharmaceutically acceptable salt thereof, which is useful as a therapeutic and/or prophylactic agent for diseases in which nav1.1 is involved and various central nervous system diseases; and a medicament containing the pyridazinone derivativeAs an active ingredient, a compound and/or a pharmaceutically acceptable salt thereof. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof. [ in the formula, M 1 Represents saturated or partially unsaturated C 4‑12 Carbocyclic groups, and the like; r 1 And R 2 Independently represent a hydrogen atom or the like; m 2 Represents a group represented by the formula (2a), etc.; x 1a 、X 1b And X 1c Independently represent N, etc.; x 2 、X 3 And X 4 Independently represent CR 3 Etc.; a. the 1 And A 2 Independently represent N, etc.; and R is 3 Represents a hydrogen atom or the like.]
These patient participants will receive 1 session of unsupervised stationary cycling exercise on every weekday of participation and be allowed up to 30min of voluntary exercise pr. session.
BACKGROUND: The accurate assessment of kidney function is vital for the early detection of kidney damage. The estimated glomerular filtration rate GFR (eGFR) from serum cystatin C (CysC) and creatinine-based equations are commonly used in clinical practice as an alternative to the invasive measured glomerular filtration rate (mGFR), which is the usually accepted overall best index of kidney function in health and disease. Recently the CKiD under 25 (CkiD U25) equations have been shown to perform well in children and young adults with chronic kidney disease (CKD). In this focused report, we evaluated the performance of the CkiD U25 equations alongside 3 non-race-corrected (NRC) eGFR equations commonly used in pediatrics in our cohort.
METHODS: mGFR measured following the intravenous injection of tracer Tc-99mDTPA was retrospectively compared with eGFR from these equations in 57 patients (6 months to 22 years) from different races/ethnicities. Ordinary least squares regression analyses were used to assess correlation between the mGFRs and eGFRs.
RESULTS: The average mGFR for this cohort was 84.1 mL/min/1.73 m2. The NRC creatinine equations overestimated eGFR across all groups, with the lowest bias for CKiD U25-creatinine (22.59 mL/min/1.73 m2). The best correlations to mGFR, P30, and lowest biases were the CKiD U25-CysC (0.6281, 80.7%, 3.72 mL/min/1.73 m2) and Schwartz CysC (0.6372, 77.2%, -4.68 mL/min/1.73 m2).
CONCLUSIONS: Overall, both CKiD U25-CysC and Schwartz CysC provide a good estimation of mGFR with the CKiD U25-CysC having the overall best performance compared to mGFR in our study.
This is an open-label, fixed-sequence, two-period study in up to 12 healthy male subjects. The present study is designed to fully characterize the rates and routes of elimination of TD 4208 using radiolabeled drug administered via the oral and IV route. This study will provide information regarding the metabolic fate of TD 4208, the need for evaluation of potential drug-drug interactions, the need for studies in special populations and the absolute oral bioavailability of TD-4208. The results from this study will allow a comprehensive comparison between animal and human routes of elimination and metabolic profiles of TD 4208.

This study will be conducted in a small number of healthy male subjects (up to n=12) to minimize the number of individuals exposed to radioactivity. Each subject will receive the following treatments: Treatment A (Period 1): 20 μg IV infusion of \[14C\] TD-4208 administered in a fasted state over 30 minutes. Treatment B (Period 2): 200 μg oral solution of \[14C\] TD-4208 administered in a fasted state. Blood, urine, feces, and vomitus (if applicable) will be collected until the subject is released during Periods 1 and 2. In Periods 1 and 2, subjects may remain in the clinical research unit for a maximum of 15 days. Between the dosing in periods 1 and 2, there will be washout intervals of at least 28 days.