anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To identify key factors influencing the therapeutic efficacy of the ketogenic diet (KD) for children with drug-resistant epilepsy and elucidate their interconnected relationships to optimize clinical practice.
METHODS: Participants were selected from children receiving KD treatment at West Second University Hospital of Sichuan University from September 2015 to October 2023. Clinical factors pre-KD and post-KD (at the third month) were analyzed systematically using an analytical framework. Descriptive analyses, univariate analyses, and multivariate regression analyses were performed for the entire cohort and subgroups of genetic and non-genetic (i.e., structural and unknown) etiologies. Thereby, the most significant predictors were identified for each relevant dependent variable. Path analysis diagrams were used for visual representation.
RESULTS: Of 156 patients, genetic etiology was prevalent (38.5%). In the genetic subgroup, channelopathies predicted lower baseline seizure frequency and increased chance of seizure freedom with KD. Frequent seizures and complex history of anti-seizure medications (ASMs) predicted severe baseline psychomotor abnormalities. Younger age at KD initiation benefited psychomotor improvement. In the non-genetic subgroup, lower baseline seizure frequency increased the likelihood of seizure freedom post-KD. Concurrent use of multiple ASMs helped achieve ≥50% seizure reduction. Boys were more likely to experience psychomotor improvement. A significant correlation was found between ≥50% seizure reduction and psychomotor improvement in both subgroups. Delayed KD initiation (longer epilepsy duration at KD start) was related to a greater number of ASMs used, infrequent seizures, and older age at epilepsy onset. In addition, patients with channelopathies had delayed initiation of KD.
SIGNIFICANCE: Children with genetic epilepsy display more pronounced characteristics of epileptic encephalopathy. Early KD intervention is crucial for channelopathies, notably SCN1A variants. For other drug-resistant epilepsy cases, KD alongside diverse ASMs may improve seizure control and developmental outcomes. However, the patient population benefiting most from early KD tends to start the treatment later, urging a re-evaluation of KD decision-making paradigms.
<P>PROBLEM TO BE SOLVED: To provide an aqueous solution type lotion/a skin paste, a tooth cleaner and a bath agent comprising tea polyphenol as a main ingredient, inhibiting discoloration and practical in resistance to long term preservation, and a bath agent easily produced, conveniently used and not staining bath tabs.  <P>SOLUTION: The aqueous solution containing high purity green tea polyphenol and ascorbic acid is used and tightly closed in a pet bottle and preserved. In case of the skin lotion, e.g., the concentration of green tea polyphenol is brought to be 25 ppm and that of ascorbic acid to be 2 ppm. In case of the tooth cleaner, the concentration of green tea polyphenol is brought to be 100 ppm-5%. In case of the bath agent, the concentration of green tea polyphenol is brought to be, e.g., about 1.0 wt.% and pH is brought to be 3.0-6.0 by adding sodium ascorbate and adjusting the rate of the ascorbate with ascorbic acid.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The invention discloses a graphene suppository and a preparation method and application thereof. The traditional Chinese medicine suppository is prepared from, by weight, 1-5 parts of graphene, 20-28 parts of honey-fried honeycombs, 15-23 parts of Japanese banana flowers, 18-26 parts of tarenna attenuata (Voigt) Hutch. and 1-8 parts of omphalia. The preparation method comprises the steps that honey-fried honeycombs and Japanese banana flowers are smashed and sieved, 20% of ethanol solution is added, sealing heat preservation treatment, ultrasonic treatment and centrifugal separation are conducted, and supernatant is obtained; tarenna attenuata (Voigt) Hutch. and omphalia are smashed and sieved, absolute ethyl alcohol is added, extraction is conducted twice, the two extracting solutions are mixed and concentrated, acetone is added, all the materials are stirred to be uniform, refrigerated and subjected to vacuum evaporation to recycle acetone, and residual liquid is obtained; graphene is smashed, sieved and stir-fried, and treated graphene is obtained; the supernatant and the residual liquid are mixed and stirred, treated graphene is added, ultrasonic treatment and heat preservation are conducted, and the suppository is obtained. The graphene suppository is definite and stable in therapeutic effect on Behcet's disease, quick in efficacy, high in cure rate and free of toxic and side effects, the Behcet's disease does not relapse after being cured, and the graphene suppository is safe to use and harmless to the heart, liver and kidney.
Oragastric tube of premature baby Hypoallergenic Flexible Patch will be detected using . Orogastric fixation will not be changed for 24 days. After 24 hours, the fixed patch will be removed using a silicone-based spray remover.
Microorganisms in the digestive tract regulate the metabolism of host cells as well as stimulate the immune system of the host. If the microbiota is in good balance, it will promote the good health of the host. In this study, using 16S rRNA sequencing, we analyzed the microbiota of three groups of shrimp: a group of normal shrimp (control group), shrimp that were killed by infection with the white spot syndrome virus (WSSV) (susceptible group), and shrimp that survived WSSV infection (resistant group). The results showed that although the alpha diversity of the microbiota was barely affected by the WSSV, the bacterial communities in the three groups had different prevalences. The resistant group harbored significantly more bacteria than both the other groups. Remarkably, the resistant group had the greatest prevalence of the phylum Bacterioidetes, the families Rhodobacteraceae and Flavobacteriaceae, and the genus Nautella, suggesting their potential as biomarkers for shrimp resistance to WSSV infection. In addition, analysis of functional diversity in bacterial communities showed that the abundance of bacterial metagenomes in two groups infected with WSSV was mostly linked to metabolism and cellular processes. The susceptible WSSV group exhibited a significant reduction in amino acid metabolism. This result suggested that metabolism was the principal factor affecting the alteration in the microbiota after WSSV infection. This overview of the gut microbiota of shrimp infected with the WSSV offers crucial insights for aquaculture management and simplifies the use of control strategies in the future.
The present invention discloses a method for determining an injury risk of a user who has performed an exercise training for a first duration. Divide the first duration into a plurality of time segments. Determine the training load in each of the plurality of time segments. A first portion of the training load is above a threshold of an exercise intensity adjusted according to a fitness condition of the user. Perform an algorithm to determine an indication mode representing a training condition of the exercise training of the user in the first duration based on the training load. Determine a criterion of the injury risk based on the first portion of the training load and the algorithm. Determine the injury risk of the user based on a comparison between the indication mode and the criterion of the injury risk.
A method for evaluating change in liver fibrosis includes determining a baseline value of a fibrosis parameter and an end-of-treatment value of the fibrosis parameter. The baseline value is associated with a first liver biopsy sample of a subject at a first time. The end-of-treatment value is associated with a second liver biopsy sample of the subject at a second time after the first time. At least one correction coefficient is applied to at least the end-of-treatment value to obtain at least a corrected end-of-treatment value of the fibrosis parameter. A change in liver fibrosis severity is determined based on at least the corrected end-of-treatment value. In one embodiment, the at least one correction coefficient comprises a liver volume correction coefficient. In one embodiment, the fibrosis parameter comprises a qFibrosis parameter.
Mouse models are vital for assessing risk from environmental carcinogens, including ionizing radiation, yet the interspecies difference in the dose response precludes direct application of experimental evidence to humans. Herein, we take a mathematical approach to delineate the mechanism underlying the human-mouse difference in radiation-related cancer risk. We used a multistage carcinogenesis model assuming a mutational action of radiation to analyze previous data on cancer mortality in the Japanese atomic bomb survivors and in lifespan mouse experiments. Theoretically, the model predicted that exposure will chronologically shift the age-related increase in cancer risk forward by a period corresponding to the time in which the spontaneous mutational process generates the same mutational burden as that the exposure generates. This model appropriately fitted both human and mouse data and suggested a linear dose response for the time shift. The effect per dose decreased with increasing age at exposure similarly between humans and mice on a per-lifespan basis (0.72- and 0.71-fold, respectively, for every tenth lifetime). The time shift per dose was larger by two orders of magnitude in humans (7.8 and 0.046 years per Gy for humans and mice, respectively, when exposed at ~35% of their lifetime). The difference was mostly explained by the two orders of magnitude difference in spontaneous somatic mutation rates between the species plus the species-independent radiation-induced mutation rate. Thus, the findings delineate the mechanism underlying the interspecies difference in radiation-associated cancer mortality and may lead to the use of experimental evidence for risk prediction in humans.
The present invention provides variant HSV-1 glycoprotein D and HSV-2 glycoprotein D molecules capable of preventing infection of cells by herpes simplex virus types 1 and/or 2. Also provided are novel purified and isolated polynucleotides encoding the variant gD molecules. HSV gD-1 and gD-2 region IV variants or fragments thereof are specifically contemplated by the invention. The presently preferred variant molecule gD-1( DELTA 290-299t) is the product of recombinant expression in Sf9 cells of a fusion protein including the signal peptide of honeybee melittin and Patton strain HSV-1 gD wherein (1) the Patton strain amino acid residues 290 through 299 of the mature gD-1 protein have been replaced with the amino acid residues arginine, lysine, isoleucine and phenylalanine, and (2) Patton strain amino acid residues 308 through 369 have been replaced with five histidine residues. When expressed in Sf9 cells, cleavage of the melittin signal peptide results in the presence of aspartate and proline residues at the amino terminus of the variant molecule. The amino acid sequence of gD-1( DELTA 290-299t) is set out in SEQ ID NO: 2 and the preferred DNA sequence encoding gD-1( DELTA 290-299t) is set out in SEQ ID NO: 1. Administration of gD variant molecules of the invention to mammalian subjects, especially humans, for the purpose of preventing HSV infection and/or ameliorating pathological sequelae of HSV infection is specifically contemplated.
OBJECTIVE: To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease (PD).
METHODS: A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients each. The electric acupuncture group was treated with electric acupuncture, while the control group was treated with Park needle pseudoacupuncture. Both groups were treated 5 times a week for a total of 4 weeks, and both groups completed 20 treatments. King's Parkinson's Pain Scale (KPPS) and visual analog scale (VAS) were used before and after treatment to evaluate the pain degree of patients. Real-time shear wave elastography (SWE) and modified Ashworth score (MAS) were used to evaluate the changes of muscle tone. Parkinson's comprehensive Score Scale (MDS-UPDRS, including UPDRSⅡ and UPDRS Ⅲ) was used to evaluate exercise ability. Hamilton Depression Scale (HAMD) score was used to evaluate the emotional changes of patients. Spearman correlation analysis was used to explore the correlation between pain degree and muscle tone, exercise ability and emotion.
RESULTS: During the study, one case fell off in the control group, and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control group. After treatment, Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment, while KPPS score, VAS score, UPDRSⅡ, UPDRS Ⅲ and modified Ashworth score were decreased, with statistical significance (P < 0.05). There was no statistical significance in control group (P > 0.05). After treatment, KPPS score, VAS score, UPDRSⅡ and UPDRS Ⅲ, MAS, HAMD score, Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group (P < 0.05). Spearman correlation analysis showed that KPPS score was positively correlated with UPDRS Ⅲ (r = 0.414, P < 0.05). KPPS score was positively correlated with HAMD score (r = 0.576, P < 0.01).
CONCLUSION: Electroacupuncture therapy can effectively improve skeletal muscle pain in patients with Parkinson's disease, reduce the muscle hardness of patients, improve patients' daily life ability, and improve patients' emotional disorders. The degree of skeletal muscle pain in PD patients is correlated with motor ability and emotional disorders, but there is no significant correlation between the degree of skeletal muscle pain and the muscle tone of PD patients.
The effects of the COVID-19 pandemic on comprehensive maternal deaths in Brazil have not been fully explored. Using publicly available data from the Brazilian Mortality Information (SIM) and Information System on Live Births (SINASC) databases, we used two complementary forecasting models to predict estimates of maternal mortality ratios using maternal deaths (MMR) and comprehensive maternal deaths (MMRc) in the years 2020 and 2021 based on data from 2008 to 2019. We calculated national and regional standardized mortality ratio estimates for maternal deaths (SMR) and comprehensive maternal deaths (SMRc) for 2020 and 2021. The observed MMRc in 2021 was more than double the predicted MMRc based on the Holt-Winters and autoregressive integrated moving average models (127.12 versus 60.89 and 59.12 per 100,000 live births, respectively). We found persisting sub-national variation in comprehensive maternal mortality: SMRc ranged from 1.74 (95% confidence interval [CI] 1.64, 1.86) in the Northeast to 2.70 (95% CI 2.45, 2.96) in the South in 2021. The observed national estimates for comprehensive maternal deaths in 2021 were the highest in Brazil in the past three decades. Increased resources for prenatal care, maternal health, and postpartum care may be needed to reverse the national trend in comprehensive maternal deaths.
The gingitrac cartridge was attached to the automixing gun and then the mixing syringe with intraoral tip was placed into the gingival sulcus and gingival retraction material was applied all around the selected abutment. After injecting the retraction material ,the corresponding comprecap was placed on to the abutment to push the material deep into the gingival sulcus. After 4 min, the comprecap with the set retraction material attached to it was removed from the patient mouth.
Ring chromosomes (RCs) are a structural aberration that can be tolerated better in acrocentric or gonosomal chromosomes. Complete RCs arise from telomere-telomere fusions. Alternatively, genomic imbalances corresponding to the ends of the chromosomal arms can be seen with RC formation. RCs are unstable in mitosis, result in mosaicism, and are associated with a "ring syndrome," which presents with growth and development phenotypes and differs from those features more frequently observed with pure terminal copy number changes. Due to variability in mosaicism, size, and genomic content, clear genotype-phenotype correlations may not always be possible. Given the rarity of RCs, this historical data is invaluable. We performed a retrospective review of individuals bearing RCs to investigate the incidence in our laboratory. This work details the methods and features seen in association with twenty-three autosomal RCs. In decreasing order, the most frequently seen autosomal RCs were 18, 22, 4, 13, 17, and 9. The additional cases detail clinical and cytogenomic events similar to those reported in RCs. As methodologies advance, insights may be gleaned from following up on these cases to improve genotype-phenotype correlations and understand the cryptic differences or other predisposing factors that lead to ring formation and development.
1,218,278. Stabilised aluminium hydroxide suspensions. MILES LABORATORIES Inc. 20 Aug., 1968, No. 39877/68. Heading A5B. Freeze-stable suspensions comprise an aluminium hydroxide gel having an antibodyproducing or immunising substance consisting of an antigen, allergen, microorganism, toxin, toxoid, metabolite or derivative of microbes which cause immunological responses, adsorbed thereon suspended in a 2 to 18% by weight aqueous solution of a water-soluble, non-toxic non-antigenic polyhdric alcohol, e.g. glycerol, sorbitol, mannitol, propylene glycol, polyethylene glycol, glucose or sucrose; polyvinylpyrrolidone or dextran. The aluminium hydroxide gel having the above mentioned substances adsorbed thereon may be formed by conventional methods including precipitation with alum of an aqueous pyridine extract of an antigenic material, addition of Al ions to an aqueous extract or solution of the substance or the direct addition of preformed aluminium hydroxide gel or suspension to a solution of the said substance.
Inflammatory bowel disease remains a difficult disease to effectively treat, especially fistulizing Crohn's disease. Perianal fistulas in the setting of Crohn's disease remain an area of unmet need with significant morbidity in this patient population. Up to one third of Crohn's patients will have perianal fistulizing disease and current medical and surgical interventions are of limited efficacy. Thus, most patients experience significant morbidity, narcotic use, and loss of employment and end up with multiple surgical interventions. Mesenchymal stem cells (MSCs) have shown efficacy in phase 3 clinical trials, but considerable infrastructure challenges make MSCs limited with regard to scalability in clinical practice. Extracellular vesicles, being derived from MSCs and capturing the secretome functionality of MSCs, offer similar physiological utility regarding mechanism, while also providing an off the shelf regenerative medicine product that could be widely used in daily clinical practice.
Thiosemicarbazones of chalcones, of general formula <FORM:0692060/IV (b)/1> where R=aryl, substituted or not; R1=alkyl, substituted or not; R11=hydrogen or alkyl, substituted or not; are prepared by the action of thiosemicarbazide upon a chalcone.  The thiosemicarbazone of benzalacetone is prepared by adding a saturated aqueous solution of thiosemicarbazide at 90 DEG  C. to a saturated solution of benzalacetone in alcohol at 60-70 DEG  C. and heating on a steam bath.  The thiosemicarbazones of salicylalacetone, 6-hydroxy-3-methyl benzalacetone and 4-acetamino-benzalacetone are prepared by similar methods.ALSO:A composition adapted for combating microorganisms of the genus Brucella comprises at least one active hydrophil component which is capable of substantially reducing the growth of Brucella in a hydrophilic medium and at least one active lipophil component which is capable of substantially reducing the growth of Brucella in a lipoidic medium.  Specified hydrophil components are: - antibiotics e.g. aureomycin, streptomycin, chloromycetin and patulin; sulpha compounds e.g. sulphadiazine and p-phenylsulphanilamide; 1,4-hydroquinone; a -naphthoquinone; and 3-methyl a -naphthoquinone. Typical lipophil components are the chloro-, bromo-, nitro- or acyl derivatives of 1,4-hydroquinone e.g. 2-bromo-, 2-chloro-, 2,5-dibromo-, 2,5-dichloroderivatives and quinacetophenone; the thiosemicarbazones of patulin; the semicarbazones of patulin; and the thiosemicarbazones of chalcones of general formula:- <FORM:0692060/VI/1> where R=aryl, substituted or not; R1=alkyl, substituted or not; R11=hydrogen or alkyl, substituted or not. Examples are the thiosemicarbazones of benzalacetone, 6-hydroxy-3-methylbenzal acetone, salicylalacetone, 4-acetamino benzalacetone and 3-nitrobenzalacetone.  Substances promoting the growth of lactobacillus e.g. galactose, lactose, glucose or stabilised lactobacilli may be added to the compositions, especially those in the form of vaginal pencils and suppositories. Examples are given of vaginal pencils containing 1,4-hydroquinone and 2-bromo-1,4-hydroquinone; lactose, galactose, glucose or stabilised lactobacilli; polymerised ethylene oxide; as such, or with the further addition of one or more of the following: thiosemicarbazone or semicarbazone of patulin, starch, paraffin wax, glycerin and gelatin.  An ointment has a base of petroleum jelly, liquid paraffin, lanolin, emulsifier and water.  Oral preparations consist of the active components and galactose, or lactose or a phosphate buffer. Pastils may have magnesium stearate as excipient.  The compositions may be administered to both man and animals by injection, orally, rectally or vaginally. Aqueous emulsions of vegetable or mineral oils may be used for general application to stables and the like.  The thiosemicarbazone of patulin is described in Specification 679,391, [Group IV (b)].  The thiosemicarbazones of chalcones of the above formula are prepared by the action of thiosemicarbazide upon a chalcone (see Group IV (b)).