anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Traditionally, patellar fractures (PFs) have been managed using metallic tension band fixation, a method often associated with a notable rate of complications. Considering these challenges, this study explores the potential of nonmetallic fixation as a treatment option for PFs. This research aims to provide robust evidence supporting the use of the nonmetallic tension band fixation technique as an effective alternative to conventional metallic tension band fixation, thereby advancing the standard of care in treating these fractures.
METHODS: This retrospective study analyzed a consecutive patient series presenting with PFs from 2008 to 2021, treated with a nonmetallic tension band fixation technique. Inclusion criteria were strictly defined to include individuals over 18 years of age with isolated PFs requiring surgical intervention. The study focused on evaluating postoperative complications and clinical outcomes, as measured by standardized scoring systems, at the final follow-up point to assess the efficacy and safety of the employed surgical technique.
RESULTS: In this study, with a mean follow-up of 64 ± 7 months, a total of 64 patients who received open reduction and internal fixation (ORIF) for PFs were enrolled. Among these, five cases required additional surgical interventions. Specifically, two cases were due to knee stiffness, while the remaining three involved complications such as superficial infection, skin irritation, or delayed wound healing. The mean postoperative values recorded for the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, Oxford knee score (OKS), and visual analog scale (VAS) were 20.4 ± 2.3, 35.5 ± 5.3, and 1.6 ± 0.4, respectively. There were no complications related to the nonmetallic fixation technique or instances of loss of reduction.
CONCLUSION: This study substantiates that nonmetallic tension band fixation is a safe and effective alternative to traditional metallic tension band fixation for patellar fractures. The study's low-complication rate and reoperation frequency underscore the value of nonmetallic implants in mitigating adverse effects and enhancing clinical outcomes.
LEVEL OF EVIDENCE: IV.
Retinal oximetry can be measured with newly developed Oxymap (Oxymap ehf, Reykjavik, Iceland). Briefly, the device simultaneously acquires digital images at two wavelengths and automatically tracks retinal vessels on both images. Retinal vessel oxygen saturation is estimated by spectrophotometric analysis of light reflected from retinal vessels and from the immediately surrounding retina. Oxygen saturation measurements are made on major temporal arteries and veins. Briefly, the first and second degree vessels are used, with the addition of third degree vessels in images where peripapillary haemorrhage prevented analysis close to the optic disc. Vessel segments chosen for analysis are used consistently for consecutive measurements in the same retina.

Retinal oximetry in various chorioretinal diseases will be measured with Oxymap.
A smell is one sense of the human body′s five senses and is used routinely. A fragrant smell causes a positive response such as a refreshing sensation, or an odor causes a negative response such as an unpleasant feeling, a psychologically uneasy feeling, etc. Lots of people live around an area emitting an odor such as a waste odor, a sewer odor, and a methane gas odor, and the odor can affect the people′s personality, characteristics, disposition, etc. when the people are consistently exposed to the odor. In the present study, a mouse is exposed to ammonia gas which is odor stress. As a result of observation of behavior change, it was verified that the mouse becomes depressed or aggressive. In order to solve the problem, a fumigation therapy and a dietary therapy were applied to the stressed mouse by using Dendropanax morbifera H. Lev. (DMH) which is effective in cancer treatment, immunity enhancement, etc. As a result of inspection of various items such as cortisol in plasma, AST, ALT, etc., it was verified that DMH alleviates the stress applied to the mouse exposed to ammonia gas. Accordingly, DMH can be applied so that people overcome depression or alleviate stress. Consequently, a smell can have a positive or negative effect on humans and a mouse according to the type and use of the smell.
PROBLEM TO BE SOLVED: To obtain a hair-growing and -nourishing agent that has excellent depilation-preventive action and shows excellent hair-growing and -nourishing effects. SOLUTION: The objective hair-growing and -nourishing agent includes a woad extract and one or two or more kinds selected from the group consisting of cell activators and blood circulation stimulators. The woad extract is obtained by extracting the roots, stems, leaves or their mixture of woads as a plant of Isatis indigotica in Brassicaceae with a solvent at room or heated temperature. As a cell activator, are cited pantothenic acid and its derivatives (pantothenyl ethyl ether), photosensitive element No.301, a ginseng extract, biotin, mononitroguiacol, hinokitiol, allantoin, and the like. The blood circulation stimulators are, for example, carpronium chloride, cepharanthin, DL-α-tocopherol, iodized garlic essence, Swertia essence, and the like. In a preferred embodiment, the amount of these cell activators or blood circulation stimulators is 0.0001-10 wt.%.
Patients starting on intravitreal anti-VEGF treatment, not receiving Omega-3 supplements. They serve as wet-AMD controls.
Consecutive patients admitted as in-patients to the Department of Gastroenterology at four University Hospitals in Denmark, with acute severe UC defined as an affirmed diagnosis of UC according to well established criteria, combined with a Mayo score of 8 or more (i.e. severe disease activity) and the need for intravenous corticosteroid treatment will be screened for participation in the study after informed consent.
<P>PROBLEM TO BE SOLVED: To provide a novel immunomodulator which can be used in the prevention and treatment of allergies and excels in safety.  <P>SOLUTION: A composition comprising a product brewed from rice as a raw material is provided as an immunomodulator. It is preferred that the above product brewed from rice as a raw material has further undergone fermentation treatment, and particularly has undergone the fermentation treatment in the presence of rice bran. Such fermentation treatments can increase the content of γ-aminobutyric acid in the product brewed from rice as a raw material and exhibits superior modulability. For example, the immunomodulator is useful as a Th1/Th2 balance modulator for modulating the Th1/Th2 balance and an antiallergic agent.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Recently, numerous studies have revealed the participation of circular RNAs (circRNAs) in cancer progression. Likewise, this research focused on circRNAs in hepatocellular carcinoma (HCC). A lowly expressed circRNA hsa_circ_0072309 in HCC was screened by analyzing the circRNA microarray GSE242797 and GSE216115 and identified in clinical specimens and cells. Subsequently, CCK-8, colony formation, and transwell assays were performed. The results revealed that hsa_circ_0072309 overexpression suppressed HCC cell proliferation, migration, invasion, and sorafenib resistance, whereas its suppression showed opposite results. Mechanistic investigation found an interaction between hsa_circ_0072309 and its host gene leukemia inhibitory factor receptor (LIFR) in HCC. We found that LIFR overexpression promoted the hsa_circ_0072309 formation. In turn, hsa_circ_0072309 recruited the E1A binding protein p300 to promote the enrichment of H3K27 acetylation (H3K27ac) in the LIFR enhancer, thus transcriptionally promoting LIFR expression. To conclude, we revealed a hsa_circ_0072309/LIFR regulatory loop in HCC, which may provide a potential target for HCC treatment.
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells such as B cells and T cells in non-lymphoid tissues induced by infection, inflammation, and tumors. They play a crucial role in the immune response, particularly in association with tumor development, where they primarily exert anti-tumor immune functions during tumorigenesis. Current research suggests that TLSs inhibit tumor growth by facilitating immune cell infiltration and are correlated with favorable prognosis in various solid tumors, serving as an indicator of immunotherapy effectiveness to some extent. Therefore, TLSs hold great promise as a valuable biomarker. Most importantly, immunotherapies aimed to prompting TLSs formation are anticipated to be potent adjuncts to current cancer treatment. This review focuses on the formation process of TLSs and their potential applications in cancer therapy.
BACKGROUND AND AIMS: Physiological shear stress promotes vascular homeostasis by inducing protective molecules in endothelial cells (EC). However, physiological shear stress has been linked to atherosclerosis progression in some individuals with heightened cardiovascular risk. To address this apparent paradox, we hypothesized that diseased arteries may exhibit reduced responsiveness to the protective effects of physiological shear stress. Consequently, we compared the transcriptome of EC exposed to physiological shear stress in healthy arteries versus atherosclerotic conditions.
METHODS: Employing 3D light sheet imaging and computational fluid dynamics, we identified NOS3 as a marker of physiological shear stress in both healthy and atherosclerotic murine arteries. Single-cell RNA sequencing was performed on EC from healthy (C57BL/6) mice, mildly diseased (Apoe-/- normal diet) mice, and highly diseased (Apoe-/- high fat diet) mice. The transcriptomes of Nos3high cells (exposed to physiological shear stress) were compared among the groups.
RESULTS: Nos3high EC were associated with several markers of physiological shear stress in healthy arteries. Clustering of Nos3high EC revealed 8 different EC subsets that varied in proportion between healthy and diseased arteries. Cluster-specific nested functional enrichment of gene ontology terms revealed that Nos3high EC in diseased arteries were enriched for inflammatory and apoptotic gene expression. These alterations were accompanied by changes in several mechanoreceptors, including the atheroprotective factor KLK10, which was enriched in Nos3high EC in healthy arteries but markedly reduced in severely diseased arteries.
CONCLUSIONS: Physiological shear stress is uncoupled from atheroprotective KLK10 within atherosclerotic plaques. This sheds light on the complex interplay between shear stress, endothelial function, and the progression of atherosclerosis in individuals at risk of cardiovascular complications.
The Asiatic lion (Panthera leo persica) is an endangered species with a slowly increasing captive and wild population. Several zoos from within the European Association of Zoos and Aquaria Ex Situ Program reported Asiatic lions with neurological signs such as (progressive) ataxia, and stargazing. The aim of this study was to evaluate the frequency (prevalence and incidence) and etiology of these clinical signs within the captive Asiatic lion population. The medical history of 74 Asiatic lions (36 healthy and 38 affected) was retrieved and reviewed for blood tests (biochemical, hematological, and retinol), diagnostic imaging (MRI and CT scans) and postmortem examinations. The data of the affected lions was compared with those of healthy lions. Between 2002 and 2020, the prevalence of ataxia ranged from 0.6% in 2004 to 13.0% in 2020. The incidence of ataxia was variable per year between 2002 and 2020 and ranged between 0 and 40%. Besides ataxia, stiffness and lameness were the most described signs in this study. Blood results showed lower total protein, ALT and creatinine, and higher phosphate in lions with neurological signs. Moreover, neurologically affected lions showed a significant lower blood retinol than the control lions (0.59-0.81 µmol/L). The most important finding in diagnostic imaging and necropsy included caudal fossa hyperostosis and cerebellar herniation. These abnormalities are similar as found in African lions (Panthera leo) with calvarial hyperostosis syndrome associated with vitamin A deficiency. Leucomyelopathy, syringomyelia (in one case combined with cerebellar herniation) and incidental mineralization of the dura mater were also described. A possible congenital/hereditary component should not be excluded.
The dose protocol would be similar to the one used in Deep Venous Thrombosis. 15 mg PO q12hr for 21 days with food, THEN 20 mg PO qDay for 6 months.
* PHENERGAN Injection has been reported to cause severe chemical irritation and damage to tissues, including gangrene, regardless of the route of parenteral administration. Intra-arterial and subcutaneous administration have resulted in more significant complications. The use of PHENERGAN Injection by intravenous injection at concentrations greater than 1 mg/mL, intra- arterial injection, or subcutaneous injection is contraindicated (see CONTRAINDICATIONS).
  * Irritation and damage can result from perivascular extravasation, intra- arterial injection, and intraneuronal or perineuronal infiltration. Inadvertent intra-arterial injection can cause severe arteriospasm. Other reported adverse reactions included burning, pain, erythema, swelling, sensory loss, palsies, paralysis, severe spasm of distal vessels, thrombophlebitis, venous thrombosis, phlebitis, abscesses, tissue necrosis, and gangrene. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required.
  * The preferred route of administration of PHENERGAN Injection is by deep intramuscular administration.
  * PHENERGAN Injection may be administered intravenously after dilution through an intravenous catheter inserted in a large vein. Preferably through a central venous catheter (see DOSAGE AND ADMINISTRATION).
  * If pain occurs at the injection site during intravenous infusion, immediately discontinue the infusion, evaluate for possible arterial injection or perivascular extravasation, and initiate appropriate medical management.
FLOW Trial is a randomized, placebo-controlled, blinded phase II trial evaluating the efficacy of coupling antidepressant therapy (e.g., selective serotonin reuptake inhibitor - fluoxetine) with exercise rehabilitation across multiple Canadian sites in 176 stroke patients. 88 patients will be enrolled in each arm of the study. Both groups will receive an exercise program in addition to standard of care rehabilitation, but only one group (the intervention group) will receive the active drug fluoxetine.

Study participants will be evaluated at baseline, post-exercise program and 6-months post-exercise program. While enrolled in the study, participants will be required to take part in a 12 week, 3 times per week exercise program. Evaluators and patients will be blind to the treatment administered. The trial is constructed with randomization to remove selection and allocation biases and to ensure greater validity in observed differences in the outcome measures. The Applied Health Research Centre (AHRC) in Toronto will act as the coordinating and analysis center.
PURPOSE:To obtain an agent containing a water-soluble beta-glucan derivative having hydroxyl group modified by the reaction with glycidol, developing excellent antiviral activity and extremely low toxicity and having excellent safety and prolonged drug action. CONSTITUTION:This water-soluble beta-1,3-glucan derivative is a compound produced by modifying hydroxyl group of beta-1,3-glucan with glycidol (excluding water-soluble paramylon derivative obtained by modifying the hydroxyl group of paramylon with glycidol and having a 6-site substitution degree of 25%). Curdlan is used as the glucan. The derivative is used as an antiviral agent (excluding the antiviral agent containing the paramylon having a hydroxyl group modified by reacting 1 pt.wt. of paramylon with 3.5-4.5 pts.wt. of glycidol). The reaction of the glucan with glycidol is carried out at an alkali concentration of 0.1-5N at 40-100 deg.C and the water solubility of the derivative is preferably >=0.1%W/W.
The aim of this study is to examine the relations between depression and psychiatric family history, candidate genes, cytokines and health-related quality of life among hemodialysis patients and patients receiving interferon treatment for hepatitis C. The investigators aim to recruit 200 hemodialysis patients and 100 patients receiving interferon treatment for hepatitis C at Chang Gung Memorial Hospital, Keelung. Our pilot study found that among hemodialysis patients, the prevalence rates of probable anxiety disorder and probably depression disorder was 25.9% and 40.0%. Among the patients receiving interferon treatment for hepatitis C, the prevalence rates of probable anxiety disorder and probably depression disorder was 30.2% and 20.7% at baseline, and 44.0% and 36.2% at 3 months after interferon treatment. The study procedure consists of 2 parts. For the first one, all the recruited hemodialysis patients will receive assessments for fatigue symptoms using Fatigue Scale, depressive symptoms using Hospital Anxiety and Depression Scale (HADS) and Montgomery Asberg Depression Rating Scale (MADRS), Short-form Health-related Quality of Life (SF-36), blood levels of IL-1β, IL-6 and TNF-αas well as psychiatric diagnostic interview with the Mini-International Neuropsychiatric Interview (MINI) and the Family Interview for Genetic Study (FIGS). The second one is a prospective follow up of patients receiving interferon treatment. Before initiating interferon treatment, the subjects will receive baseline assessments using the same scales mentioned above. The investigators will genotype the 5-HTTLPR triallelic polymorphism on all subjects. The follow-up visits are at month 1, month 3, termination, and one month after termination of interferon program. This proposed project will provide a broad view and better understanding of the gene-environment interaction in the etiology of depression.
A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of Fig. 3 of the attached drawings; their metal complexes have the formula of Fig. 1. The verdins have the formula of Fig. 4 of the attached drawings; their metal complexes have the formula of Fig. 2. The porphyrin derivatives have the formula of Fig. 9 of the attached drawings; their metal complexes have the formula of Fig. 10. Solutions of the benzochlorins, verdins, porphyrin derivatives and metal complexes which are physiologically acceptable for intravenous administration are also disclosed, as are emulsions or suspensions of the solutions, and compositions which additionally include cyclodextrin, and wherein the molecules of the benzochlorin, verdin, porphyrin derivative or metal complex are encapsulated within the molecules of the cyclodextrin. The solvent for the solutions can be a product of the reaction of ethylene oxide with castor oil. A method for detecting and treating tumors in human and animal patients is also disclosed. The method comprises administering one of the benzochlorins, verdins, porphyrin derivatives or metal complexes to the patient. For detection, the tumor area is then illuminated with ultra violet light; for treatment, the tumor area is illuminated with visible light of a wavelength at which the benzochlorin, verdin, porphyrin derivative or complex administered shows an absorption peak.
Participants will be treated at dose level 2: Ipilumumab 3mg/kg + Nivolumab 1mg/kg IV day 1 every 3 weeks for 4 cycles, followed by Nivolumab 360 mg every 3 weeks. Sacituzumab Govitecan 10 mg/kg IV will be administered days 1 and 8 every 3 weeks.
PROBLEM TO BE SOLVED: To enable an end user to previously and easily record a medical fixed form document as character string data, to convert them into display by a graphic user interface, to realize mouse-driven operation environment and to correctly and efficiently prepare a medical chart. SOLUTION: An electronic medical chart device by a computer is provided with database recording medical information and an input means inputting information in the database. The device is also provided with an example file where the fixed form examples of input examples are previously recorded by individual medical situations and a conversion means converting character string data on the example file into the display of the graphic user interface. The easy operation environment by a mouse operation is realized with the example file as the display of the graphic user interface. A necessary part is selected from the example file by the mouse operation. The selected example is taken out, the other example is deleted and the selected example is filled in the prescribed file.
OBJECTIVES: This study aims to develop deep learning (DL) models for the quantitative prediction of hearing thresholds based on stimulus-frequency otoacoustic emissions (SFOAEs) evoked by swept tones.
DESIGN: A total of 174 ears with normal hearing and 388 ears with sensorineural hearing loss were studied. SFOAEs in the 0.3 to 4.3 kHz frequency range were recorded using linearly swept tones at a rate of 2 Hz/msec, with stimulus level changing from 40 to 60 dB SPL in 10 dB steps. Four DL models were used to predict hearing thresholds at octave frequencies from 0.5 to 4 kHz. The models-a conventional convolutional neural network (CNN), a hybrid CNN-k-nearest neighbor (KNN), a hybrid CNN-support vector machine (SVM), and a hybrid CNN-random forest (RF)-were individually built for each frequency. The input to the DL models was the measured raw SFOAE amplitude spectra and their corresponding signal to noise ratio spectra. All DL models shared a CNN-based feature self-extractor. They differed in that the conventional CNN utilized a fully connected layer to make the final regression decision, whereas the hybrid CNN-KNN, CNN-SVM, and CNN-RF models were designed by replacing the last fully connected layer of CNN model with a traditional machine learning (ML) regressor, that is, KNN, SVM, and RF, respectively. The model performance was evaluated using mean absolute error and SE averaged over 20 repetitions of 5 × 5 fold nested cross-validation. The performance of the proposed DL models was compared with two types of traditional ML models.
RESULTS: The proposed SFOAE-based DL models resulted in an optimal mean absolute error of 5.98, 5.22, 5.51, and 6.06 dB at 0.5, 1, 2, and 4 kHz, respectively, superior to that obtained by the traditional ML models. The produced SEs were 8.55, 7.27, 7.58, and 7.95 dB at 0.5, 1, 2, and 4 kHz, respectively. All the DL models outperformed any of the traditional ML models.
CONCLUSIONS: The proposed swept-tone SFOAE-based DL models were capable of quantitatively predicting hearing thresholds with satisfactory performance. With DL techniques, the underlying relationship between SFOAEs and hearing thresholds at disparate frequencies was explored and captured, potentially improving the diagnostic value of SFOAEs.
The Recall Study (Retaining Cognition while Avoiding Late-Life Depression) is a study for adults 60 and older who have noticed mild memory changes in themselves or a loved one. Mild memory changes may feel stressful and therefore increase an individual's risk of developing depression. This research project will test whether Problem Solving Therapy (PST) is successful in preventing major depression for those living with mild cognitive impairments. We will also examine the effect of modest exercise on mood. You will participate in 8 to 12 PST sessions over 16 weeks. All treatments are provided at no cost and there is compensation for participation.