anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Federally Qualified Community Health Centers (FQHCs) are on the frontline of efforts to improve healthcare equity and reduce disparities exacerbated by the COVID-19 pandemic. This study assesses the provision and equity of preventive care and chronic disease management by FQHCs before, during, and after the pandemic.
METHODS: Using electronic health record data from 210 FQHCs nationwide and employing segmented regression in an interrupted time series design, preventive screening and chronic disease management were assessed for 939,053 patients from 2019 to 2022. Care measures included cancer screenings, blood pressure control, diabetes control, and childhood immunizations; patient-level factors including race and ethnicity, language preference, and multimorbidity status were analyzed for equitable care provision. Analyses were conducted in 2023-2024.
RESULTS: Cancer screening rates and blood pressure control initially declined after the onset of the pandemic but later rebounded, while diabetes control showed a slight increase, later stabilizing. Racial and ethnic disparities persisted, with Asian individuals having a higher prevalence of screenings and blood pressure control, and Black/African American individuals facing a lower prevalence for most screenings but a higher prevalence for cervical cancer screening. Hispanic/Latino individuals had a higher prevalence of various screenings and diabetes control. Disparities persisted for Native Hawaiian/Other Pacific Islander and American Indian/Alaska Native individuals and were observed based on language and multimorbidity status.
CONCLUSIONS: While preventive screening and chronic disease management in FQHCs have largely rebounded to pre-pandemic levels following an initial decline, persistent disparities highlight the need for targeted interventions to support FQHCs in addressing healthcare inequities.
Patients with recurrent/metastatic (R/M) platinum-refractory squamous cell carcinoma of the head and neck (SCCHN) have fewer treatment options and harbor an especially poor prognosis. Maintaining treatment with anti-PD1 agents beyond response evaluation criteria in solid tumors-defined disease progression (TBP) has been shown to be efficacious in several solid tumors, including head and neck cancer. We present the case of a platinum-refractory locally recurrent, PD-L1-negative hypopharyngeal carcinoma, that received second-line nivolumab which was then maintained beyond progression under the following criteria: no Eastern Cooperative Oncology Group performance status deterioration, no rapidly progressive disease, no severe toxicity, and evidence of overall treatment benefit. The patient achieved a partial response 8 months after starting second-line nivolumab, with progressive disease at 26 months, then followed by the first TBP with nivolumab lasting for 15 months due to a new tumor progression. A second TBP with nivolumab lasting for 7 months, was followed by a third TBP with nivolumab for 12 months and achieving a major tumor response. Treatment is still ongoing 60 months after starting nivolumab, with excellent tolerance to therapy. Maintaining anti-PD1 agents beyond progression is an efficacious treatment option for patients with R/M SCCHN, that may achieve very durable disease control and even late major responses.
Women who attain menopause before age 40 years (or as defined by clinical criteria). Perimenopausal women are those typically above age 40 years and experience secondary amenorrhea/ oligomenorrhea.
Vegetable flavone extracts, are purified by selective adsorption of the extract soln. successively on a complex-forming ion-exchange resin, to remove the heavy metals, then stirring with an aq suspension of an acid clay, pref. montmorillonite and finally stirring with neutral activated Al2O3. The last two stages must be carried out in closed vessels under N2. In between stages, the soln is cooled to O degree C, adjusted to pH 2.0 with H2SO4 and stands for 48 hours before decanting. The purified soln is adjusted to pH 5.0 with NaOH or KOH and either treated chemically to separate the flavonoids, or dried immediately, pref. by lyophilisation, to give a dry powder (I). (I) may be used in medicinal- or cosmetic prepns and are an allergic and apyrogenic, so that they may be used for injections or transcutaneous applications.
This study aimed to determine whether trimethylamine N-oxide (TMAO) was involved in sympathetic activation in aging and the underlying mechanisms. Our hypothesis is TMAO reduces P2Y12 receptor (P2Y12R) and induces microglia-mediated inflammation in the paraventricular nucleus (PVN), then leading to sympathetic activation in aging. This study involved 18 young adults and 16 old adults. Aging rats were established by injecting D-galactose (D-gal, 200 mg/kg/d) subcutaneously for 12 weeks. TMAO (120 mg/kg/d) or 1% 3, 3-dimethyl-l-butanol (DMB) was administrated via drinking water for 12 weeks to investigate their effects on neuroinflammation and sympathetic activation in aging rats. Plasma TMAO, NE and IL-1β levels were higher in old adults than in young adults. In addition, standard deviation of all normal to normal intervals (SDNN) and standard deviation of the average of normal to normal intervals (SDANN) were lower in old adults and negatively correlated with TMAO, indicating sympathetic activation in old adults, which is associated with an increase in TMAO levels. Treatment of rats with D-gal showed increased senescence-associated protein levels and microglia-mediated inflammation, as well as decreased P2Y12R protein levels in PVN. Plasma TMAO, NE and IL-1β levels were increased, accompanied by enhanced renal sympathetic nerve activity (RSNA). While TMAO treatment exacerbated the above phenomenon, DMB mitigated it. These findings suggest that TMAO contributes to sympathetic hyperactivity in aging by downregulating P2Y12R in microglia and increasing inflammation in the PVN. These results may provide promising new target for the prevention and treatment of aging and aging-related diseases.
The invention discloses an extract with the functions of inflammation prevention and liver protection, which is prepared from propolis through a great deal of process research. Strict activity experiment shows that the extract has the inhibiting effect on human leukocyte elastase and has the protection effect on liver injury caused by carbon tetrachloride. The extract can be applied to development of plant source inflammation prevention and liver protection products. At present, the propolis is utilized primitively in China. As a raw material for producing plant source inflammation prevention and liver protection products, the propolis extract which is disclosed by the invention has the advantages of high eating security and simple process. A tablet prepared from the propolis extract is simple in prescription and preparation method, stable in quality and beneficial to popularization and application.
PURPOSE: A make-up cosmetic composition containing a binder and powder is provided to express various colors and to enable point make-up. CONSTITUTION: A make-up cosmetic composition contains a powder containing pigment; and a binder containing volatile materials and oil. The volatile material is alcohol. The oil is ester oils, silicone oils, or hydrocarbon oils. The content ratio of volatile material and oil is 40:60-60:40. A method for manufacturing the composition comprises: a step of preparing powder containing pigment; a step of preparing the binder containing oil and volatile materials; and a step of dispersing the powder to the binder.
OBJECTIVES: Quality improvement may reduce the incidence and severity of intraventricular hemorrhage in preterm infants. We evaluated quality improvement interventions (QIIs) that sought to prevent or reduce the severity of intraventricular hemorrhage.
METHODS: PubMed, CINAHL, Embase, and citations of selected articles were searched. QIIs that had reducing incidence or severity of intraventricular hemorrhage in preterm infants as the primary outcome. Paired reviewers independently extracted data from selected studies.
RESULTS: Eighteen quality improvement interventions involving 5906 infants were included. Clinical interventions in antenatal care, the delivery room, and the NICU were used in the QIIs. Four of 10 QIIs reporting data on intraventricular hemorrhage (IVH) and 9 of 14 QIIs reporting data on severe IVH saw improvements. The median Quality Improvement Minimum Quality Criteria Set score was 11 of 16. Clinical intervention heterogeneity and incomplete information on quality improvement methods challenged the identification of the main reason for the observed changes. Publication bias may result in the inclusion of more favorable findings.
CONCLUSIONS: QIIs demonstrated reductions in the incidence and severity of intraventricular hemorrhage in preterm infants in some but not all settings. Which specific interventions and quality improvement methods were responsible for those reductions and why they were successful in some settings but not others are not clear. This systematic review can assist teams in identifying potentially better practices for reducing IVH, but improvements in reporting and assessing QIIs are needed if systematic reviews are to realize their potential for guiding evidence-based practice.
This invention relates to a polymeric polyphenol containing beverage. In particular it relates to a substantially clear ambient temperature beverage comprising tea solids derived from fermented tea. The invention also relates to a method for improving the clarity of a polymeric polyphenol containing liquid composition. It has long been observed that on cooling an aqueous black tea infusion from about 90 degrees Celsius to ambient temperature, a marked increase in the turbidity of the infusion can be seen leading ultimately to precipitation of up to about 30% w/w of the total tea solids. This precipitate is known as tea cream. It is thought that this precipitate originates from initial self-associations of polymeric polyphenols and association with caffeine thereby forming nano-clusters. These nano-clusters are not themselves responsible for any turbidity or precipitation of tea solids. However as the solubility of the polymeric polyphenols further reduces on cooling of the aqueous black tea infusion, these nano-clusters then aggregate into larger sub-micelles and ever larger micelles which are responsible for the turbidity and precipitate. A solution to the aforementioned problem is provided in a first aspect of the invention by a beverage comprising tea solids, a liquid vehicle, added protein and added anionic polysaccharide, wherein the beverage has a cream inhibition (Cl) of 70-100%, preferably 80-100%, wherein Cl = (1-((OD S -OD B )/( OD O -OD B ))) 100 where OD S  is the optical density of the beverage, OD B  is the optical density of the tea solids in a 25% w/w aqueous solution of ethanol and OD O  is the optical density of the beverage but in the absence of the protein and anionic polysaccharide additional to any in the tea solids, the optical density being measured at a fixed path length at 600nm and at 4 degrees Celsius after equilibration at 4 degrees Celsius for 24 hours.
Methods and systems for interactively creating and submitting insurance claims and determining whether the submitted claims are in condition for payment by an insurer. A medical technician operating a client computer establishes communication with a remote server. The remote server transmits a claim form to the client computer for display to the medical technician. Using the claim form, the technician enters patient identification information, which is transmitted to the server to determine whether the patient is a beneficiary of an approved insurance plan. If the patient is a beneficiary, the technician can prepare an insurance claim using the claim form displayed by the client computer. The technician enters a diagnosis code and a treatment code representing the diagnosis and treatment of the patient. The diagnosis and treatment codes are transmitted to the remote server, which processes the codes to determine whether the claim corresponds to health care services that are approved for payment. If the insurance claim is not in condition for payment, the medical technician is notified. The medical technician can then amend the insurance claim as necessary and resubmit the claim.
FIELD: biotechnology.SUBSTANCE: invention refers to biotechnology and concerns application of Rickettsia sibirica subsp. sibirica Baevo-107/87 strain for obtaining diagnostic preparations for rickettsial disease detection. Rickettsia sibirica subsp. sibirica Baevo-107/87 strain is isolated from imago of Dermacentor marginatus ticks. Baevo-107/87 strain is successfully cultivated on cell culture of Vero E6 and developing chick embryos. Strain is deposited in the State collection of II-III bacteria of pathogenicity of Federal State Budgetary Institution Research Center for Epidemiology and Microbiology named after Honorable Academician N. F. Gamaleya of the Ministry of Health of the Russian Federation.EFFECT: rickettsia sibirica subsp_ sibirica Baevo-107/87 strain can be used for laboratory diagnostics and obtaining diagnostic preparations for diagnosing rickettsial disease caused by Rickettsia sibirica subsp_ sibirica.1 cl, 2 ex
The TIKOSYN clinical program involved approximately 8,600 patients in 130 clinical studies of normal volunteers and patients with supraventricular and ventricular arrhythmias. TIKOSYN was administered to 5,194 patients, including two large, placebo-controlled mortality trials (DIAMOND CHF and DIAMOND MI) in which 1,511 patients received TIKOSYN for up to three years.

In the following section, adverse reaction data for cardiac arrhythmias and non-cardiac adverse reactions are presented separately for patients included in the supraventricular arrhythmia development program and for patients included in the DIAMOND CHF and MI mortality trials (see CLINICAL STUDIES, Safety in Patients with Structural Heart Disease, DIAMOND Studies, for a description of these trials).

In studies of patients with supraventricular arrhythmias, a total of 1,346 and 677 patients were exposed to TIKOSYN and placebo for 551 and 207 patient years, respectively. A total of 8.7% of patients in the dofetilide groups were discontinued from clinical trials due to adverse events compared to 8.0% in the placebo groups. The most frequent reason for discontinuation (>1%) was ventricular tachycardia (2.0% on dofetilide vs. 1.3% on placebo). The most frequent adverse events were headache, chest pain, and dizziness.
The invention belongs to the technical field of genes, and particularly discloses an MMP20 gene mutant and application thereof. One aspect relates to an MMP20 gene mutant, the sequence of which is shown in SEQ ID NO. 1, and the 356 th base is mutated from G to A. The mutant has a plurality of expression forms, such as nucleic acid, polypeptide and the like. Another aspect relates to the use of a reagent for detecting a mutant MMP20 gene in the preparation of a kit or device for screening or diagnosing familial hypercholesterolemia. And further relates to a preparation for promoting MMP20 expression or application of over-expressed MMP20 in preparing an LDLR low-expression biological model or a familial hypercholesterolemia biological model and a method for promoting MMP20 expression. The invention determines the connection between the c.356G > A mutation of MMP20 and familial hypercholesterolemia, and provides a new treatment scheme for treating the familial hypercholesterolemia according to the connection, and provides a means for diagnosing and treating the familial hypercholesterolemia in particular; while partly defining the association of MMP20 with LDLR.
Past research of ICBT offered in routine care has found that patients and therapists often recommend "personalizing" the delivery of ICBT, for example, by increasing the length of time therapist support is available or offering booster sessions after treatment has ended. To date, in terms of ICBT, there has been limited research on the impact of extending support after treatment materials have been delivered or offering a booster session.

In this trial, the investigators will examine if the efficacy of ICBT is improved by offering an extended period of support to clients (from 8 weeks to 12 weeks) or by being offered a booster session at 16 weeks after treatment enrollment (yes vs no). Follow-up assessments will be conducted at 8, 16 and 26 weeks after treatment enrollment. Primary outcomes are reduced anxiety and depression. Secondary outcomes include reduced panic, social anxiety, trauma, quality of life, disability, work productivity, and healthcare use. The impact of these factors on intervention usage (e.g., completion rates, log-ins, emails sent) and treatment satisfaction will also be examined.
Macroautophagy/autophagy acts as an anti-tumor mechanism in early cancer stages but promotes growth in established tumors. Similarly, miRNAs function as tumor suppressors or oncogenes, depending on their target genes. This reciprocal relationship between autophagy and miRNAs is a well-studied area, primarily focused on how miRNAs regulate autophagy-related genes. Our research provides innovative insights into how autophagy selectively controls miRNAs. For instance, MIR224 is preferentially degraded within autophagosomes, leading to the upregulation of SMAD4 and suppressing hepatocellular carcinoma (HCC) tumorigenesis. Conversely, autophagy positively regulates MIR449A by degrading EP300/p300 to activate FOXO1 and facilitate MIR449A transcription in colorectal cancer (CRC). In conclusion, our findings reveal the role of autophagy in maintaining the cellular balance of two miRNAs to mitigate tumorigenic stresses and highlight that autophagy-regulated miRNA profiles may serve as diagnostic and therapeutic markers for cancer development.
The invention provides a method and system for predicting the life of a printed label. Various embodiments shown herein disclose a method comprising receiving, by a processor, one or more patient characteristics associated with a first patient, the one or more patient characteristics comprising at least a type of sanitization and/or a frequency of sanitization usage. Further, the method includes receiving one or more image characteristics associated with an image of a patient bracelet worn by the first patient. The method also includes training a Machine Learning (ML) model that defines a relationship between the one or more patient characteristics and the one or more image characteristics. The ML model is used to predict the number of days until the patient bracelet associated with the second patient is deemed unavailable. In addition, the method includes generating instructions to the printing device to print a new patient bracelet for the second patient based on the number of days being less than a predetermined number of days threshold.
PURPOSE: Following spinal fixation, postoperative imaging is routinely performed. The value of routine postoperative imaging and its impact on the surgical decision remains uncertain, especially in degenerative cases. Moreover, routine postoperative imaging is not free and is an ionizing radiation. This study investigated the value of postoperative imaging after uneventful uncomplicated elective posterior lumbar fixation.
METHODS: This case series retrospectively reviewed the medical records of patients who underwent elective posterior lumbar fixation surgeries at our institution within two years. A series of 98 cases met our selection criteria. Their mean age was 51.2 years. We reviewed the decisions taken after performing the routine postoperative images. We searched for further diagnostic or imaging studies, revision surgery, or an extended hospital stay.
RESULTS: We found no particular decision was made after performing the postoperative imaging after uneventful uncomplicated elective posterior lumbar fixation surgeries. Moreover, there was no change in the hospital stay or the regular postoperative clinical management for all the included patients. No revision surgery was required based on the postoperative routine images.
CONCLUSIONS: We found that routine postoperative imaging after posterior fixation of a degenerative lumbar spine is of limited value. A randomized, controlled study is helpful to confirm this finding.
PROBLEM TO BE SOLVED: To prepare a water-in-oil microemulsion having high safety to a living body by using the ester compd. of a lower alcohol and a higher fatty acid as an oil component and bile acid or its salt as a surfactant and further using an auxiliary activator. SOLUTION: The ester compd. of a 2-6C, preferably 3-4C lower straight chain or branched chain mono- or polyhydric alcohol and a 10-20C, preferably 14-18C straight chain or branched chain satd. or unsatd. fatty acid is, e.g. used as an oil component. Bile acid having >=2 OH groups such as cholic acid, chenodeoxycholic acid or deoxycholic acid or its alkali metallic salt, e.g. used as a surfactant. The ester of a 10-20C, preferably 12-18C fatty aid and sorbitol or glycerol is, e.g. used as an auxiliary activator.
INTRODUCTION: Pre-pregnancy obesity is a significant public health concern with profound implications for maternal and child health. The burgeoning evidence suggests that maternal obesity prior to conception is intricately linked with an increased risk of gestational complications, as well as with adverse neonatal outcomes. Furthermore, the long and short-term health of offspring, including the risk of early motor development impairment, obesity, and metabolic syndrome in childhood and adulthood, may be adversely affected as well. Addressing pre-pregnancy obesity is critical for improving overall maternal and child health outcomes, and therefore, the aim of this study was to evaluate the connections linking pre-pregnancy obesity with infants' motor development within the first twelve months of infants' lives.
MATERIAL AND METHODS: This study included 200 mother-infant pairs divided into two groups based on their pre-pregnancy body mass index values. To assess infants' early motor development, we used the Alberta Infant Motor Scale (AIMS) and evaluated the parameters of infants' early motor development at the ages of three, six, nine, and twelve months.
RESULTS: Pre-pregnancy overweight/obesity was significantly associated with excessive gestational weight gain (p < 0.001), fetal macrosomia (p = 0.022), and a family history of diabetes and cardiovascular diseases (p = 0.048 and p = 0.041, respectively), as well as with all observed parameters of early motor development at the ages of three, six, nine, and twelve months: AIMS 3 months total (p < 0.001), AIMS 6 months total (p < 0.001), AIMS 9 months total (p < 0.001), and AIMS 12 months total (p < 0.001). Furthermore, pre-pregnancy overweight/obesity was a significant predictor for AIMS 6 months total (p = 0.043) and AIMS 6 months supination (p = 0.017).
CONCLUSIONS: Pre-pregnancy obesity is a critical determinant of pregnancy outcomes and offspring early motor development, with possible far-reaching implications for children's long-term well-being. Addressing this issue requires a comprehensive approach that includes preconception weight management, targeted interventions during the pregnancy and postpartum periods, and ongoing research to better understand the underlying mechanisms and develop effective strategies for prevention and management.
Sunitinib 50 mg by mouth daily for 28 consecutive days. Nephrectomy will occur approximately 24 hours after the last dose of sunitinib.