anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Improving the adoption and implementation of policies to curb non-communicable diseases (NCDs) is a major challenge for better global health. The adoption and implementation of such policies remain deficient in various contexts, with limited insights into the facilitating and inhibiting factors. These policies have traditionally been treated as technical solutions, neglecting the critical influence of political economy dynamics. Moreover, the complex nature of these interventions is often not adequately incorporated into evidence for policy-makers. This study aims to systematically review and evaluate the factors affecting NCD policy adoption and implementation.
METHODS: We conducted a complex systematic review of articles discussing the adoption and implementation of World Health Organization's (WHO's) "best buys" NCD policies. We identified political economy factors and constructed a causal loop diagram (CLD) program theory to elucidate the interplay between factors influencing NCD policy adoption and implementation. A total of 157 papers met the inclusion criteria.
RESULTS: Our CLD highlights a central feedback loop encompassing three vital variables: (1) the ability to define, (re)shape, and pass appropriate policy into law; (2) the ability to implement the policy (linked to the enforceability of the policy and to addressing NCD local burden); and (3) ability to monitor progress, evaluate and correct the course. Insufficient context-specific data impedes the formulation and enactment of suitable policies, particularly in areas facing multiple disease burdens. Multisectoral collaboration plays a pivotal role in both policy adoption and implementation. Effective monitoring and accountability systems significantly impact policy implementation. The commercial determinants of health (CDoH) serve as a major barrier to defining, adopting, and implementing tobacco, alcohol, and diet-related policies.
CONCLUSION: To advance global efforts, we recommend focusing on the development of robust accountability, monitoring, and evaluation systems, ensuring transparency in private sector engagement, supporting context-specific data collection, and effectively managing the CDoH. A system thinking approach can enhance the implementation of complex public health interventions.
OBJECTIVE: Cervical cancer screening rates are low in Japan. Therefore, when a woman is pregnant, this is a good opportunity to visit an obstetrics and gynecology clinic to have cervical cytology. This study aimed to clarify the association between cervical cancer screening and the management of pregnant women's health.
METHODS: We prospectively examined the relationships between cervical cytological results during prenatal checkups and the following factors: participant's background, cytological sampling instruments, and awareness of cytological results.
RESULTS: Of the 2725 participants, 71 showed abnormal results defined as atypical squamous cells of undetermined significance or higher grade (ASC-US+). ASC-US+ detection rates were higher in smokers, younger participants, those with a low education, those without cancer screening in the past 2 years, and those who received cytology using a spatula or brush. A multivariable logistic regression analysis identified smoking (adjusted odds ratio: 2.99 [95% confidence interval: 1.41-6.33]) and a spatula/brush (adjusted odds ratio: 2.46 [95% confidence interval: 1.09-5.53]) as independent variables associated with detecting ASC-US+. Among the participants, 39.4% (28/71) self-reported "no abnormalities," despite obtaining an ASC-US+ result.
CONCLUSIONS: Pre-pregnancy smoking and cytological sampling tools may contribute to detecting ASC-US+. Patients with detected abnormalities need accurate information and reliable follow-up.
The single-arm Phase II exploratory study designed to evaluate the safety and efficacy of the study drug will include 20-50 subjects to explore the safety and preliminary efficacy of BAT1308 combined with platinum-based chemotherapy ± Bevacizumab. Dynamic analysis will be conducted after the inclusion of 20 subject. If the safety of this combination regimen is manageable and the efficacy meets expectations, the enrollment in the Phase II study will be stopped and the Phase III study will be entered. The Phase III study is a randomized, double-blind, multicenter clinical study of BAT1308 combined with platinum-based chemotherapy ± Bevacizumab versus placebo plus platinum-based chemotherapy ± Bevacizumab as first-line therapy for PD-L1-positive (CPS ≥ 1) persistent, recurrent or metastatic cervical cancer. PFS and OS will be used as the combined endpoints, and a superiority design will be adopted with a total sample size of 476 subjects. Stratified block randomization will be performed based on the following random factors: patients will be stratified based on the presence of metastatic diseases at the time of diagnosis (Yes vs. No), PD-L1 CPS (1-10 vs. ≥ 10) and planned use of Bevacizumab (Yes vs. No).
The disclosure relates to methods of reducing static on hair or a cloth material, reducing hair frizz and/or increasing shine on hair by wiping the hair or cloth material with a dry wipe product. The dry wipe product comprises a flexible substrate having a first side and a second side; and either an anhydrous composition, or an aqueous composition, disposed over the first and/or second side(s) of the flexible substrate. When hair or cloth material is wiped with a side of the dry wipe product having the anhydrous composition or the aqueous composition disposed thereon, the anhydrous composition or aqueous composition is transferred from the flexible substrate of the dry wipe product to the hair or cloth material. The anhydrous compositions and aqueous compositions of the instant disclosure reduce static on hair and/or cloth, reduce hair frizz and/or increase shine on hair. The dry wipe products of the. instant disclosure are particularly beneficial for hair care because they are dry, portable., disposable,.may be biodegradable, and comprise compositions that are safe for personal use.
BACKGROUND: Multiple factors impact ability to achieve urinary continence in cloacal malformation including common channel (CC) and urethral length and presence of spinal cord abnormalities. Few publications describe continence rates and bladder management in this population. We evaluated our cohort of patients with cloacal malformation to describe the bladder management and continence outcomes.
METHODS: We reviewed a prospectively collected database of patients with cloacal malformation managed at our institution. We included girls ≥3 years (y) of age and evaluated their bladder management methods and continence. Dryness was defined as <1 daytime accident per week. Incontinent diversions with both vesicostomy and enterovesicostomy were considered wet.
RESULTS: A total of 152 patients were included. Overall, 93 (61.2%) are dry. Nearly half (47%) voided via urethra, 65% of whom were dry. Twenty patients (13.1%) had incontinent diversions. Over 40% of the cohort performed clean intermittent catheterization (CIC), approximately half via urethra and half via abdominal channel. Over 80% of those performing CIC were dry. In total, 12.5% (n = 19) required bladder augmentation (BA). CC length was not associated with dryness (p = 0.076), need for CIC (p = 0.253), or need for abdominal channel (p = 0.497). The presence of a spinal cord abnormality was associated with need for CIC (p = 0.0117) and normal spine associated with ability to void and be dry (p = 0.004) CONCLUSIONS: In girls ≥ 3 y of age with cloacal malformation, 61.2% are dry, 65% by voiding via urethra and 82% with CIC. 12.5% require BA. Further investigation is needed to determine anatomic findings associated with urinary outcomes.
LEVEL OF EVIDENCE: IV.
To stabilize the quality of microorganism inspection irrespective of the level of experience of an operator.SOLUTION: A start information acquisition unit 201 acquires instruction information as start information that indicates instructions of a doctor. A process determination unit 203 determines a start process on the basis of the acquired start information. A print data output unit 204 outputs print data for work information that indicates the work content of a determined start process to be printed to a label. A work information acquisition unit 205 acquires work information indicated by the code printed to a work label. An input control unit 206 accepts input of work result to an image for input. The start information acquisition unit 201 acquires the acquired work information and the inputted work result as start information of a new process. The process determination unit 203 determines a start process on the basis of the start information, and the print data output unit 204 outputs print data for the work information that indicates the work content of the determined start process to be printed to a label.SELECTED DRAWING: Figure 4
BACKGROUND AND AIMS: Effective management of patients' pain, anxiety, and discomfort during colonoscopy is crucial for successful completion of the procedure, patient adherence to follow-up examinations, and patient satisfaction. Virtual reality (VR) interventions, as a nonpharmacologic and innovative solution, have demonstrated promising results in managing these outcomes. Nevertheless, there is limited evidence on their effectiveness and implementation. This trial aimed to test clinical effectiveness and identify factors to facilitate the implementation of VR during colonoscopy.
METHODS: A hybrid type 1 effectiveness implementation, parallel randomized controlled, open-label trial was conducted. Fifty patients were randomized (1:1) to a VR or a control group. The effectiveness (pain, anxiety, discomfort, medication use, and satisfaction) and implementation (reach, adoption, implementation, and maintenance) outcomes were assessed before, during, and after colonoscopy.
RESULTS: Patients in the VR group reported significantly lower pain (P = .043) and discomfort (P <.0001) during colonoscopy, had a higher number of completed colonoscopies without sedation (P = .003), and showed higher satisfaction (P = .032). The major barrier to the implementation and maintenance of the VR intervention was inadequate VR content design. Staff were most worried about altered patient communications, unclear responsibilities, increasing workload, and patient safety. Patients expressed willingness to reuse VR glasses and to suggest them to other patients.
CONCLUSIONS: VR can be used as a nonpharmacologic method for pain management and for overcoming anxiety and discomfort during colonoscopy. VR can improve patients' satisfaction and diminish the need for sedative medications; accordingly, it has the potential to promote cooperation and compliance among patients and increase screening colonoscopy rates. (Clinical trial registration number: NCT05723861.).
The invention relates to a two-phase drug-release multilayer drug-loaded nanofiber mat and a preparation method thereof. The fiber mat is a multilayer drug-loaded nanofiber membrane which consists of a water-soluble polymer, a water-insoluble polymer and a drug. The nanofiber membrane has the following two structures: a shell layer is the drug-contained water-soluble polymer, and a core layer is the drug-contained water-insoluble polymer; the shell layer is the drug-contained water-insoluble polymer, and the core layer is the drug-contained water-insoluble polymer. A preparation method for a nano analgesic comprises the following steps of: (1) preparing spinning solution containing analgesic ketoprofen; (2) preparing a multilayer nanofiber membrane through performing coaxial electrostatic spinning on the prepared spinning solution, and drying to obtain the drug-loaded nano analgesic. The nano analgesic can be used for rapidly and durably easing pains, can be easily carried, is convenient in administration and can be used for administrating drugs into intestinal tracts in the manner of targeting. The invention has the advantages that the preparation method is simple and is low in cost, and has no special requirements on equipment; and the two-phase drug-release multilayer drug-loaded nanofiber mat can be produced on a large scale.
A method for remotely reviewing medical data allows medical data to be transmitted over a vulnerable network to a physician's mobile device. The method sends data to be transmitted through a console, and a data server to reach the mobile device. The method includes separating patient's medical file into a demographics layer and a data layer, separately encrypting the demographic layer and data layer using different encryption keys, and providing servers in a communication and processing system with a decryption key for the layer processed by such server. Medical file data may be separated into more than two layers. After reviewing the data, physicians may transmit their comments from their mobile device to the requestor by going through the same system. Separately encrypting different parts of a patient medical record enables processing and communication of patient medical files by intermediary servers without risking disclosure of sensitive patient information.
INTRODUCTION: Morocco is no exception to the global phenomenon of an ageing population. The number of people aged 60 and over rose from one million to 4.5 million between 1970 and 2022. In terms of health, 64.4% of Moroccan seniors are affected by at least one chronic disease, and almost a third suffer from disability. We aimed to estimate the prevalence and identify the factors associated with frailty among the elderly in the Essaouira province of Morocco.
METHODS: a descriptive and analytical cross-sectional survey of 384 people aged 65 and over attending health centres in Essaouira province was conducted between March 2022 and January 2023. Data were collected using a self-administered questionnaire. The Fried phenotype was used to assess frailty in the participants.
RESULTS: according to Fried's phenotype, 46.4% of the elderly were frail. Multivariate analyses showed that frailty was associated with family type [OR=1.9; 95% CI 1.4-2.6], professional activity [OR=2.2; 95% CI 1.2-3.9], financial difficulties [OR=1.7; 95% CI 1.1-2.8] and undernutrition [OR=2.9; 95% CI 1.7-4.8].
CONCLUSION: implementing a screening strategy and speeding up the process of generalising social protection are actions that will make it possible to reduce the prevalence of frailty among the elderly, prevent its complications and act on its main determinants in Morocco.
Online Interpretation Training Condition 2 provides three sessions of a computerized training. Each session will last approximately 20-30 minutes, and participants will undergo 1 session each week.
FIELD: medicine, particularly, remedies of vegetable origin with antiinflammatory and resorbing action. SUBSTANCE: oil is a mixture of oily extracts of fresh raw material of yellow sweetclover, common wormwood or wild camomile, bog gnaphalium and vaseline oil taken in ratio 2:1:1:1, respectively. The oil may be used for treatment of thrombophlebites, varicoses of lower extremities, hematomas, contusions, trophic ulcers and mastites. The proposed remedy has no side effects and positively influences on processes of tissue appearance, promotes resorbing of formed thrombi, softening of induration and elasticity of tissues. EFFECT: higher efficiency. 1 cl, 1
The present invention relates a chimeric antigen receptor, which has a structure of X-Y-CD3zeta-M-N; wherein X comprises a tumor targeting antibody or a ligand or receptor capable of specifically binding to a tumor. Y is an intracellular region of a costimulatory receptor selected from ICOS, CD28, CD27, HVEM, LIGHT, CD40L, 4-1BB, OX40, DR3, GITR, CD30, TIM1, SLAM, CD2, and CD226; M is an intracellular region of a gamma chain family cytokine receptor, the cytokine receptor being selected from IL2Ra, IL2Rb, IL4Ra, IL7Ra, IL9Ra, IL15Ra, and IL21Ra. N is an intracellular region of IL2Rg. The present invention further provides a CAR-T cell constructed from the recombinant expression vector of said chimeric antigen receptor, a preparation method therefor and the use thereof. The CAR-T cell of the present invention significantly improves tumor killing capacity and amplification capacity. The CAR T cell comprises a third signal receptor, has a potential effect-enhancing function, and only works on the CAR-T cell, thereby reducing the risk of causing an immune side effect.
OBJECTIVES: To assess the association between allostatic load in early pregnancy and sleep-disordered breathing (SDB) during pregnancy.
METHODS: High allostatic load in the first trimester was defined as ≥ 4 of 12 biomarkers (systolic blood pressure, diastolic blood pressure, body mass index, cholesterol, low-density lipoprotein, high-density lipoprotein, high sensitivity C-reactive protein, triglycerides, insulin, glucose, creatinine, and albumin) in the unfavorable quartile. SDB was objectively measured using the Embletta-Gold device and operationalized as "SDB ever" in early (6-15 weeks) or mid-pregnancy (22-31 weeks); SDB at each time point was analyzed as secondary outcomes. Multivariable logistic regression was used to test the association between high allostatic load and SDB, adjusted for confounders. Moderation and sensitivity analyses were conducted to assess the role of allostatic load in racial disparities of SDB and obesity affected the relationship between allostatic load and SDB.
RESULTS: High allostatic load was present in 35.0% of the nuMoM2b cohort. The prevalence of SDB ever occurred among 8.3% during pregnancy. After adjustment, allostatic load remained significantly associated with SDB ever (aOR= 5.3; 3.6-7.9), in early-pregnancy (aOR= 7.0; 3.8-12.8), and in mid-pregnancy (aOR= 5.8; 3.7-9.1). The association between allostatic load and SDB was not significantly different for people with and without obesity. After excluding BMI from the allostatic load score, the association decreased in magnitude (aOR= 2.6; 1.8-3.9).
CONCLUSION: The association between allostatic load and SDB was independent of confounders including BMI. The complex and likely bidirectional relationship between chronic stress and SDB deserves further study in reducing SDB.
The invention discloses a traditional Chinese medicine preparation for treating quinsy and a preparation method thereof. The traditional Chinese medicine preparation for treating the quinsy is prepared from, by weight, honeysuckle flowers, fructus forsythiae, radix platycodonis, rhizoma belamcandae, radix achyranthis bidentatae, radix sophorae flavescentis, rhizoma coptidis, fructus gardeniae, licorice roots, folium isatidis, periostracum cicada, radix glycyrrhizae preparata, bengal dayflower herb, herb of elsholtzia bodinieri Vant., honeysuckle stems, herba scutellariae barbatae, fructus xanthii, rhizomes of petasites japonicus (Sieb. et Zucc.) Fr. Schmidt, thinleaf crazyweed roots, radix dipsaci from Sichuan of China, cortex moutan, semen oroxyli, radix ophiopogonis, herba houttuyniae, rhizoma saururi and fructus corni. The traditional Chinese medicine preparation adopts the high-quality traditional Chinese medicinal materials for achieving scientific compatibility, accords with theories of the traditional Chinese pharmacology and the modern medicine and pharmacology, has the functions of clearing away heat and toxic materials, dissipating stagnation and eliminating swelling and cooling the blood and eliminating addiction, is mainly used for treating the quinsy, swelling and the symptoms such as a fever and pain which are caused by tonsil inflammations and has the advantages that the treatment course is short, the treatment effect is good, the quinsy does not relapse, safety is achieved, and no toxic or side effect is generated when the traditional Chinese medicine preparation is used for treating the quinsy.
The incidence of bone metastases in advanced cancer patients is substantial, representing 70% of all metastatic sites. Approximately 5-10% of all patients with bone metastases develop pathological fractures. Surgical reconstruction can be helpful following fracture or prophylactically in cases of an impending fracture. In these cases, post-operative radiation is the current clinical practice in North America and many countries around the world. Post-operative radiation has the potential to support bone healing and prevent tumor progression while also decreasing the need for subsequent orthopaedic surgeries to the same site. A recent systematic review, however, challenged the evidence on its efficacy and adoption as standard of care in this patient population. As well, post-operative radiation requires additional visits to the radiation centre (associated with added costs and efforts for both the patients and the healthcare system). There is also a "pain flare" phenomenon, in which up to 40% of patients receiving radiation for palliative bone metastases experience pain within 1-5 days following radiation. The pain can last for 10 days and may acutely mask potential clinical benefits of radiation.

Given that there is potential negative impact to these patients who are palliative with a relatively short lifespan, it is important that the efficacy of post-operative radiation is rigorously evaluated.

We propose a multicenter randomized controlled trial to assess the efficacy of post-operative radiation following orthopaedic surgery in patients with lower extremity bone metastases. 300 patients with pending or established lower extremity pathological fracture will be recruited to a trial of surgery alone vs. surgery with post-operative radiation. The primary endpoint is a second surgery to the same site within 12 months. Secondary outcomes include quality of life, pain and functional outcome markers, radiation or re-irradiation as applicable, a second surgery within 24 months for those patients alive, overall survival and cost effectiveness.
The intervention will be characterized by be based on Mindfulness exercises (e.g. body scan, gentle yoga, sitting, grounding and walking meditation), relaxation techniques and cognitive rehabilitation exercises. walking), relaxation techniques and cognitive rehabilitation exercises. The objective is to provide specific practical skills to learn how to deal with difficult and/or stressful situations managing emotions and intercurrent thoughts. The intervention is proposed to last for a total of 5-6 sessions lasting 45 minutes each, two sessions per week, for a three-week commitment. In addition, between sessions, reflection materials, readings or exercises will be offered. The intervention will be conducted in telemedicine by a Psychologist, who has experience in conducting these interventions and who receives regular supervision. The sessions will be conducted through special platform and audio-recorded to ensure the reliability of the data collected, prior consent.
NEW MATERIAL:Chitinovorin-C shown by the formula and its salt. Showing the following physical and chemical properties (all are measured by Na salt except molecular weight). Molecular weight: 416. Solubility: soluble in water or dimethyl sulfoxide, slightly soluble or insoluble in methanol, ethanol, acetone, chloroform, or ethyl acetate. Color reaction: positive in ninhydrin reaction, or Sakaguchi reaction. Appearance: colorless powder. An acidic substance having amphoteric properties, etc. USE:An antibacterial agent against Gram-positive and Gram-negative bacteria, and a raw material for a novel antibiotic containing formylamino group. PREPARATION:A strain such as Flavobacterium chitinovorum (FERM-P 7085), etc. belonging to the genus Flavobacterium is cultivated in a medium preferably at 5.5-8.5pH at 25-32 deg.C for 20-80hr.