anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a liquid capsule which comprises medicament, an auxiliary material and an outer shell of the capsule, wherein the medicamentis used as an active ingredient. A content is in a liquid state or a semisolid shape. The liquid capsule is prepared by a way that the medicine active ingredient is mixed with liquid to be filled in the outer shell of the capsule. The present invention has the advantages of high biologic utilization rate, good sealability, accurate content and beautiful appearance. The medicament is mixed with oil, the surface of the medicament is coated by the oil, and thus, the stability of the medicament can be increased. The liquid capsule saves many steps before the capsule is filled, and required equipment investment is less. Simultaneously, the liquid capsule saves the equipment and the technology of capsule smelting, press, drying and the like which are required for soft capsule production.
BACKGROUND: Obesity is a complex metabolic disorder that is associated with several diseases. Recently, precision nutrition (PN) has emerged as a tailored approach to provide individualised dietary recommendations.
AIM: This review discusses the major intrinsic and extrinsic components considered when applying PN during the management of obesity and common associated chronic conditions.
RESULTS: The review identified three main PN components: gene-nutrient interactions, intestinal microbiota, and lifestyle factors. Genetic makeup significantly contributes to inter-individual variations in dietary behaviours, with advanced genome sequencing and population genetics aiding in detecting gene variants associated with obesity. Additionally, PN-based host-microbiota evaluation emerges as an advanced therapeutic tool, impacting disease control and prevention. The gut microbiome's composition regulates diverse responses to nutritional recommendations. Several studies highlight PN's effectiveness in improving diet quality and enhancing adherence to physical activity among obese patients. PN is a key strategy for addressing obesity-related risk factors, encompassing dietary patterns, body weight, fat, blood lipids, glucose levels, and insulin resistance.
CONCLUSION: PN stands out as a feasible tool for effectively managing obesity, considering its ability to integrate genetic and lifestyle factors. The application of PN-based approaches not only improves current obesity conditions but also holds promise for preventing obesity and its associated complications in the long term.
The invention relates to medicine and pharmacology, in particular, to preparations for the treatment of gastric and duodenal ulcer. A pharmaceutical composition contains at least one proton pump inhibitor (PPI) and at least one prebiotic from the group of aliphatic alcohols, or disaccharides, or polysaccharides, or fructooligosaccharides, or galactooligosaccharides. The content of the composition components in wt.%: proton pump inhibitor - 0.05-25; prebiotic from the group of aliphatic alcohols, or disaccharides, or polysaccharides, or fructooligosaccharides, or galactooligosaccharides - 40-95; excipients - up to 100. The composition allows effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics, as well as the comprehensive treatment of ulcer disease associated with a helicobaterial infection. The claimed pharmaceutical composition makes it possible, in conditions of an elevated pH of the stomach contents, to actively stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment. Also proposed is a method for the treatment of gastric and duodenal ulcer, whereby the eradication of H. pylori is attained during the course of therapy providing enteral administration of the pharmaceutical composition of PPI and prebiotic.
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease with unknown cause. It mainly affects joints and, without proper treatment, negatively impacts their movement, causes painful deformities, and reduces the patients' quality of life. Current treatment options consist of various types of disease-modifying antirheumatic drugs (DMARDs), however 20-30% of patients are partially resistant to them. Therefore, development of new drugs is necessary. Possible option are compounds exhibiting their action via endocannabinoid system, which plays an important role in pain and inflammation modulation. One such compound - cannabidiol (CBD) has already been shown to attenuate synovitis in animal model of RA in in vivo studies. However, it has low bioavailability due to its low water solubility and lipophilicity. This issue can be addressed by preparation of a lipid containing formulation targeting lymphatic system, another route of absorption in the body. Materials and Methods: CBD-containing emulsion was prepared by high-shear homogenization and its droplet size distribution was analysed by optical microscopy. The relative oral bioavailability compared to oil solution as well as total availability of CBD were assessed in a cross-over study in rats and absorption of CBD via lymphatic system was observed. The effect of CBD on the animal model of RA was determined. Results: Compared to oil solution, the emulsion exhibited higher absolute oral bioavailability. Significant lymphatic transport of CBD was observed in all formulations and the concentrations in lymph were calculated. The therapeutic effect of CBD on RA was confirmed as an improvement in clinical symptoms as well as morphological signs of disease activity were observed during the study. Conclusion: In this work, we prepared a simple stable emulsion formulation, determined the pharmacokinetic parameters of CBD and calculated its absolute bioavailability in rats. Moreover, we successfully tested the pharmaceutical application of such a formulation and demonstrated the positive effect of CBD in an animal model of RA.
Gastro- resistant, entero-soluble granules of pharmaceutical material are prepd. by the following prcess: a suspension of the pharmaceutical substance (I) in a liquid is added repeatedly and in small quantities to an inert granular core material (II) and after each addition, the cores are covered with an absorbant anti-agglomerating agent (III). The cores are then coated with sugar, dried, coated with a 30% emulsion of methacrylic acid-methylethyl methacrylate copolymer, and finally with a methacrylic acid-methyl methacrylate copolymer. The process is partic. suitable for the prepn. of proteic material, esp. Ferritin for oral ferruginous therapy. The process gives a more gastro-resistant and entero-soluble prod. than is obtainable by prior art methods, enabling higher doses to be given over longer periods.
BACKGROUND: Preoperative microvascular invasion (MVI) of liver cancer is an effective method to reduce the recurrence rate of liver cancer. Hepatectomy with extended resection and additional adjuvant or targeted therapy can significantly improve the survival rate of MVI+ patients by eradicating micrometastasis. Preoperative prediction of MVI status is of great clinical significance for surgical decision-making and the selection of other adjuvant therapy strategies to improve the prognosis of patients.
PURPOSE: Established a radiomics machine learning model based on multimodal MRI and clinical data, and analyzed the preoperative prediction value of this model for microvascular invasion (MVI) of hepatocellular carcinoma (HCC).
METHOD: The preoperative liver MRI data and clinical information of 130 HCC patients who were pathologically confirmed to be pathologically confirmed were retrospectively studied. These patients were divided into MVI-positive group (MVI+) and MVI-negative group (MVI-) based on postoperative pathology. After a series of dimensionality reduction analysis, six radiomic features were finally selected. Then, linear support vector machine (linear SVM), support vector machine with rbf kernel function (rbf-SVM), logistic regression (LR), Random forest (RF) and XGBoost (XGB) algorithms were used to establish the MVI prediction model for preoperative HCC patients. Then, rbf-SVM with the best predictive performance was selected to construct the radiomics score (R-score). Finally, we combined R-score and clinical-pathology-image independent predictors to establish a combined nomogram model and corresponding individual models. The predictive performance of individual models and combined nomogram was evaluated and compared by receiver operating characteristic curve (ROC).
RESULT: Alpha-fetoprotein concentration, peritumor enhancement, maximum tumor diameter, smooth tumor margins, tumor growth pattern, presence of intratumor hemorrhage, and RVI were independent predictors of MVI. Compared with individual models, the final combined nomogram model (AUC: 0.968, 95% CI: 0.920-1.000) constructed by radiometry score (R-score) combined with clinicopathological parameters and apparent imaging features showed the optimal predictive performance.
CONCLUSION: This multi-parameter combined nomogram model had a good performance in predicting MVI of HCC, and had certain auxiliary value for the formulation of surgical plan and evaluation of prognosis.
The "Bupivacaine Arm" includes all patients who will receive bupivacaine injection on their trocar sites after the laparoscopic hysterectomy is completed. Bupivacaine (0.25%) will be injected through the closed incisions ensuring subcutaneous tissue, fascia, muscle and pre-peritoneal space of the trocar incision sites are infiltrated. All incisions 8 mm and greater are injected with 10 cc while all incisions 5 mm or less are infiltrated with 5 cc.
A fermentation method using an auxiliary enzyme for yeast, enzyme dough, brewing dough and bread, bun, steamed roll, bagel and a method for brewing xiao ban enzyme, and a method for making enzyme yeast are disclosed. The fermentation method includes using xiao ban dough, vegetable and fruit, whole grains and nuts. Xiao ban dough is the fundamental fluid with overall ratio of 3%˜300%. The method for making auxiliary enzyme for yeast includes using vegetable and fruits, whole unlit) and various nuts, and mixing with xiao ban dough. The duration of fermentation process is between 0-90 days, and the fermentation temperature is between 5 Degree Celsius to 30 Degree Celsius. The auxiliary enzyme for yeast can efficiently enhance food color, odor and taste and prolong food preservation.
Participants who responded to interferon alfa-2A (either pegylated interferon alfa-2A or recombinant interferon alfa 2A) treatment during the parent study will continue to receive the same treatment in this study. Pegylated interferon alfa-2A will be administered subcutaneously once weekly and recombinant interferon alfa 2A will be administered subcutaneously once daily, until disease progression, withdrawal, or death whichever occurs first (up to approximately 3 years).
Enteric capsules are prepd. by capsules being treated in vacuo to eliminate air, and then contacted with a gas that blocks the reactive chemical groups of the gelatin. Contact is maintained for 12-18 hours, pref. 14-16 hours, and then they are contacted with clean air for 60-80 hours, pref. 72 hours, in a stove at 40 deg.C, the air being changed every 24 houurs. The capsules are opened on a capsuler without emptying the contents, the open capsules are sprayed with a silicone soln. in chloroform and the capsules closed. The closed capsules are immersed for a few seconds in a soln. of silicone in chloroform and are then dried. They may be sealed, if desired, by treatment with gum arabic in a mixture of castor oil and absolute alcohol. The process gives a better product at a more rapid rate than other methods of making enteric capsules.
The invention relates to applications of winged euonymus total flavones in an antiallergic agent or a cosmetic, and a preparation method. A technology scheme comprises: using ultrasonic extraction, condensing an extract, passing a macroporous adsorption resin column, washing out by using distilled water and ethanol as an eluant, and condensing, drying and purifying the eluate, to obtain winged euonymus total flavones. For preparing an antiallergic agent or a cosmetic, 1-10% winged euonymus total flavones is used as a main material, and 0.01-6% of methoxy homogalacturonans is used as a auxiliary material; prepared medicaments comprise: a tablet, a capsule, a paste agent and a inunction; and prepared cosmetics comprise: a cream, an emulsion, a lotion, a mask, and a massage paste. Shown in an experiment result to a mouse, the winged euonymus total flavones have obvious antipruritic effect, body fluid and cellular immunity enhancing effect and in vitro anti-allergic effect. The preparation has a 100% effective rate on treatment of urticaria. Compared with a same kind of product, the preparation has characteristics of substantial effect and good security.
The diagnosed patients with epicondylosis will be treated with HILTERAPIA HIRO 3.O for a total of four sessions during the entire duration of the treatment protocol. Parameters to be evaluated are tenderness, pain upon active resistive motion and DASH scores. After every treatment session of HILTERAPIA HIRO 3.O, these said parameters will be recorded initially on the first treatment, one week after the initial treatment, two weeks after the initial treatment and four weeks after the initial treatment. Patient is advised to follow-up on the 6th and 12 month post initial HILTERAPIA HIRO 3.O treatment for the reevaluation of the parameters. Tenderness is described as pain upon palpation and is further categorized into, 0= no tenderness, 1 = mild tenderness, 2 = tenderness evident on facial expression and 3 = patient screams upon palpation. Pain is also noted upon active resistive motion of extension/flexion, supination/pronation. Classification includes; 0 = no pain and 1 = mild pain with full power, 2 = severe pain with full power, and 3 = muscle weakness with pain. And for functional scoring will be using the DASH which is a multidimensional disease specific, brief, self-administered measure of symptoms and functional status among subjects with upper limb disorders. The DASH consists of a 30-item questionnaire with 5 response options for each item with a scale ranging from 0, which indicates "least disability," to 100, which indicates "most disability." A change in 12.7 DASH score points is considered to represent clinically significant functional improvement.
Participants will be administered topically on the scalp after fasting for at least 10 hours pre-dose and 5 hours post-dose. After the administration subject should not wash her head for at least 5 hours. Each one mL dose of 2% topical minoxidil will be carefully measured to provide 20 mg of minoxidil using the syringe provided with each bottle.
PURPOSE:To obtain an economic powdery mugwort, readily drinkable and utilizable for health mugwort tear or mugwort SAKE, by drying young leaves of mugwort, pulverizing the dried leaves, fermenting the pulverized leaves and roasting the fermented leaves to remove the strong smell and bitterness unique to the mugwort. CONSTITUTION:Powdery mugwort obtained by drying young mugwort leaves, pulverizing the dried leaves and fermenting the pulverized leaves. The fermentation is carried out by adding a yeast fungus, small amount of sugar (about 5% glucose) and hot water (30%) to 100% powdery mugwort and at a constant temperature for 1-3 days. The above-mentioned powdery mugwort is roasted to give a finished product. Ash in the mugwort can be decomposed and removed by the fermentation, and strong smell and bitterness unique to the mugwort can be removed. The product can be made fragrant by the roasting. Mugwort components. e.g. thiamine or pantothenic acid, are readily extracted by a method for packing the powdery mugwort in a bag and pouring hot water thereon, etc. The resultant product can be utilized for health mugwort tear, mugwort SAKE, mugwort bath, etc.
Prebiotics, including inulin-type fructans (ITFs) are a group of the naturally occurring plant carbohydrates stored in various amounts in tubers, bulbs and tuberous roots of several edible fruits and vegetables and in particularly large amounts in the tubers of Helianthus tuberosus (Jerusalem artichoke) and Cichorium intybus (chicory). Because of their unique structural properties, they are not hydrolyzed by the enzymes of the upper intestinal digestive tract and reach the colon unchanged, therefore are classified as prebiotics. Prebiotics are defined as selectively fermented ingredients that allow specific changes in the composition and/or balance of the microbiota. ITFs, particularly the mixture of short- and long-chain polymers, indicate several beneficial effects, including the positive changes in the histological picture of the intestine (proliferation in the crypts and Goblet cells, longer intestinal villi) and modulation of the endocrine and immune functions. Moreover, they have a great potential as agents improving or maintaining a balanced intestinal microbiota both in the lumen and at the mucosal surface, to one in which bifidobacteria and lactobacilli come to greater prominence. This, so-called healthier flora, should provide increased resistance to gut infections and may also have immuno-modulatory properties. Until now, inulin and fructooligosaccharide (FOS) have been tested mainly in animal models of inflammatory bowel diseases (IBD). Reports on animal colitis model suggests that prebiotics have the anti-inflammatory properties as they reduce the inflammation symptoms, along with the increase in bifidobacteria or lactobacilli number, and in some reports, the increase in the concentration of butyrate in the gut.

Prebiotics are known as substances affecting beneficially the organism by restoring the intestinal microbiota balance, stabilizing the intestinal barrier and modulating the endocrine and immune functions. In many persons suffering from celiac disease (CD), despite a gluten-free diet (GFD), an impaired intestinal barrier functionality, accompanied by altered intestinal microbiota and ongoing intestinal inflammation is observed. For these reasons, prebiotics could be a promising and low-risk adjuvant in the dietetic management of CD. It was hypothesized that Synergy 1 consumed by CD children as a supplement of a GFD will affect beneficial the intestinal permeability and intestinal microbiota without side effects. The primary objective of this randomized placebo-controlled study was to determine the effect of 3-months consumption of Synergy 1 versus placebo, as the supplements of a GFD, on the intestinal permeability in CD children, in particular on the concentration of the intestinal fatty acid binding protein (iFABP) as a biomarker of intestinal permeability. The secondary objective was to determine the effect of Synergy 1 versus placebo applied in GFD on the changes in the gut microbiota quantity and metabolism in CD children.
Group 5 are participants with metabolic abnormality in the non-intervention group. Group 5 use the health information push technology with three months.
The optimal surgical strategy for treatment of patients with resectable synchronous rectal liver metastases remains controversial. To answer whether synchronous rectal cancer liver metastases (SLM) should be resected simultaneously with primary cancer or should be delayed, We conducted a randomized, controlled trial to compare the safety and efficacy of simultaneous versus delayed resection of the rectum and liver. Patients with rectal cancer and resectable SLM were randomly assigned to either simultaneous or delayed resection of the metastases. The primary outcome was the rate of major complications (Clavien-Dindo grade≥III) within 30 days following surgery. Secondary outcomes included disease-free and overall survival. A consecutive patients of rectal cancer with liver metastasis from ZhongShan hospital, Fudan university were enrolled and randomly assigned to simultaneous liver resections and staged hepatectomies. Post-operative complications, peri-operative mortality, long-term survival were compared.
A drug database system that is particularly adapted for drug prescribing and drug dispensing activities is disclosed. In accordance with one aspect of the present invention, information on the usage, dosing and contraindications for a plurality of drugs is provided via a communications link to persons desiring such information. All information is provided in response to a request that includes specific information. The information provided can be of different types and varies with the information in the request. The information provided may be provided to the person making the request or to another person associated with the person making the request. Advantageously, the system provides real-time access to a plurality of persons requesting drug information. In addition, the drug information stored in the system may be dynamically modified. Such modifications are provided by permitting selective access to the database by drug manufacturers, drug researchers and the like. Accordingly, the most up-to-date information on a drug is provided.
Ischemic stroke (IS) is one of the most impairing complications of sickle cell anemia (SCA), responsible for 20% of mortality in patients. Rheological alterations, adhesive properties of sickle reticulocytes, leukocyte adhesion, inflammation and endothelial dysfunction are related to the vasculopathy observed prior to ischemic events. The role of the vascular endothelium in this complex cascade of mechanisms is emphasized, as well as in the process of ischemia-induced repair and neovascularization. The aim of the present study was to perform a comparative transcriptomic analysis of endothelial colony-forming cells (ECFCs) from SCA patients with and without IS. Next, to gain further insights of the biological relevance of differentially expressed genes (DEGs), functional enrichment analysis, protein-protein interaction network (PPI) construction and in silico prediction of regulatory factors were performed. Among the 2469 DEGs, genes related to cell proliferation (AKT1, E2F1, CDCA5, EGFL7), migration (AKT1, HRAS), angiogenesis (AKT1, EGFL7) and defense response pathways (HRAS, IRF3, TGFB1), important endothelial cell molecular mechanisms in post ischemia repair were identified. Despite the severity of IS in SCA, widely accepted molecular targets are still lacking, especially related to stroke outcome. The comparative analysis of the gene expression profile of ECFCs from IS patients versus controls seems to indicate that there is a persistent angiogenic process even after a long time this complication has occurred. Thus, this is an original study which may lead to new insights into the molecular basis of SCA stroke and contribute to a better understanding of the role of endothelial cells in stroke recovery.