anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In Vietnam, herbal extracts have been used as a long-standing tradition to treat diabetic patients, but effects of these extracts have not been studied adequately. Based on previous results in experimental animals, we have selected the plant Gynostemma pentaphyllum (GP), which grows in the mountain region of Northern Vietnam. GP extract had a hypoglycemic effect on mice and rats, and was shown to contain a substance, phanoside, which stimulates insulin secretion. In addition, GP has been shown to reduce both hyperglycemia and hyperlipidemia in diabetic Zucker fatty rats.

The present study aimed at investigate effects of GP extract, administered as a "tea", and compared with placebo in a randomized, double-blind trial in drug-naive patients with newly diagnosed type 2 diabetes. All patients also received instructions about diet and physical exercise. In addition to monitoring effects on plasma glucose regulation, we also studied possible effects on plasma lipids, kidney and liver function as well as body weight and blood pressure.
Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the world's population. Antipsychotic drugs remain the cornerstone in the pharmacotherapy of schizophrenia. However, none of the available drugs is ideal, in particular because of their complex safety profile and the limited effectiveness against certain symptom domains. Whereas positive symptoms respond to treatment the effects on negative symptoms and cognitive impairment are only very modest.

Thus present treatment options leave room for improvement and call for new, more effective pharmacotherapies for the treatment of schizophrenia. In the current study, patients suffering from schizophrenia and experiencing clinically significant symptoms of the disease will be included. Eligible patients will be randomised to blinded treatment with either flexible doses of Lu 31-130 or flexible doses of a standard antipsychotic treatment (olanzapine) for 12 weeks. The efficacy (including potential effects on cognitive symptoms) and the safety of Lu 31-130 will be explored in comparison to olanzapine.
Allogeneic stem cell transplantation (alloHCT) is considered the only potentially curative treatment option for MDS patients and is therefore often considered the standard treatment for mainly higher-risk MDS patients up to the age of 75 years. One common approach to "bridge" higher-risk MDS from the time of diagnosis to transplantation is a treatment with hypomethylating agents such as azacitidine due to its anticipated low toxicity profile. Alternative strategies are intensive 7+3 chemotherapy with anthracycline and cytarabine or direct and immediate transplantation. By this strategy the time interval for donor search can be significantly prolonged leading to a higher proportion of success.Nevertheless, not every patient initially eligible for transplantation undergoes this procedure subsequently. A direct prospective comparison of different therapeutic approaches as outlined above versus CPX-351 prior to alloHCT has not been performed so far and is subject of the PALOMA trial. We hypothesize that CPX-351 will lead to higher and more durable response rates including a more favourable safety profile and long-term outcome compared to currently used conventional care regimens approaches prior to alloHCT.
A medical swab comprises one or more layers (2,3) of muslin, the cut edges (4,5) of which are turned up and folded in on themselves to form a pouch held together by a rubber ring (6). The cut edges (4,5) are sealed to prevent loose fibres from entering a wound. The edges (4,5) of every muslin layer (2,3) in the swab are sealed, pref. with a thermoplastic which is applied by immersion or as a strip coating. The sealed edges extend at least one, pref. three, filaments away from the cut edges (4,5). An X-ray contrast material is added to the sealant. USE/ADVANTAGE - Medical purposes. Prevents even small filaments from falling out of the swab during use.
Patients will have a Statseal Advance RAD (SS) disc applied after withdrawing the radial sheath 2-4 cm. A Tegaderm dressing will be applied to secure the disc position. The TR band will be applied over the SS disc with the center of the balloon (the green dot) over the center of the SS disc. The TR band will be inflated with 8cc of air (which is typically occlusive pressure), and the sheath removed. No deflation will occur immediately. After 20 minutes of pressure, 3 cc of air will be removed from the TR band. After an additional 40 minutes (60 minutes after procedure), the TR band will be completely deflated.
FIELD: chemical industry. SUBSTANCE: described are acetic acid derivatives of formula I:   wherein L, M, Q and T are as defined in claim 1. Compounds are useful for treatment or prophylaxis of diseases associated with binding of adhesive proteins with thrombicytes and also aggregation of thrombicytes and cell-cell adhesion. Compounds are prepared by detachment of protective groups in corresponding protected compounds or by conversion of cyan group into amidine group in corresponding nitriles. EFFECT: improved properties of the title compounds. 23 cl, 193 ex, 1 tbl
A microsphere comprises a core, an intermediate functional layer and an outer solid oxide coating. The core which may be buoyant, preferably hollow may comprises a synthetic polymer, a natural polymer, a co-polymer, a block co-polymer, polymethylmethacrylic acid, a protein, a glass, a ceramic or a ceramic oxide. The functional layer may be laid down as nanoparticles and may comprise a magnetizable agent such as a paramagnetic agent, a superparamagnetic agent, iron, nickel, iron oxide, a spinel ferrite or an alloy, a fluorescent or coloured agent such as a pigment, paint, polymeric organic pigment or porphyrin or a radioactive agent such as iodine-125, iodine 131, palladium, radium, iridium or caesium. The solid oxide coating may be less than 25 microns such as 0.2 to 100nm and may comprise an oxide of aluminium, titanium, silicon, magnesium or zirconium. Priming layers, anchoring agents such as functional binding agents and coupling agents may be used. An effector agent such as a protein, an antibody, a lectin, an enzyme, a polypeptide, a nucleotide, a polysaccharide, a metal -ion sequestering agent, biotin or avidin may be present on the outer surface of the solid oxide coating. The invention provides a more robust microsphere that can be used without any or limited damage to the functional layer and may be manipulated in a magnetic field, injected into a body, used in separation procedure or sprayed from a paint gun.
1. Captopril tablets comprising a filler and binding agent, a disintegrating agent, a lubricant and a glidant agent wherein the filler and binding agent is a 1.5:1 - 1:1 weight ratio mixture of lactose and microcrystalline cellulose and the total amount of said mixture is 60-80 % by weight of the total weight of the tablet. 2. Tablets according to claim 1 wherein the total amount of the mixture of lactose and microcrystalline cellulose is 67-75 % by weight of the total weight of the tablets. 3. Tablets according to claim 2 wherein the total amount of the mixture of lactose and microcrystalline cellulose is 69-70 % by weight of the total weight of the tablets. 4. Tablets according to any of claims 1-3 wherein the disintegrating agent is corn starch, carboxymethyl starch, partially hydrolized starch, carboxymethyl cellulose or cross-linked polyvinyl pyrrolidone, the amount thereof being 1-20 % by weight related to the total weight of the tablets. 5. Tablets according to any of claims 1-3 wherein the lubricant is stearine, magnesium stearate, calcium stearate, sodium stearyl fumarate or hydrogenated castor oil, in an amount of 0.2-3 % by weight related to the total weight of the tablets. 6. Tablets according to any of claims 1-3 wherein the glidant agent is colloidal silica in an amount of 0.2-1 % by weight related to the total weight of the tablets. 7. Tablets according to any of claims 1-3 wherein the lactose is lactose monohydrate having an average particle size of 50-200 μm. 8. Tablets according to claim 7 wherein the lactose is lactose monohydrate having an average particle size of 80-160 μm. 9. Tablets according to any of claims 1-3 wherein 90 % of the microcrystalline cellulose has an average particle size of 20-150 μm. 10. Tablets according to claim 9 wherein 90 % of the microcrystalline cellulose has an average particle size of 50-100 μm. 11. Process for the preparation-of captopril tablets containing a filler and binding agent, a disintegrating agent, a lubricant and a glidant agent which comprises using as a filler and binding agent a 1.5:1 - 1:1 mixture of lactose and microcrystalline cellulose, the amount of said mixture being 60-80% by weight related to the total weight of the tablets. 12. Process according to claim 11 which comprises using lactose, microcrystalline cellulose, disintegrating agents, lubricant and/or glidant agents as defined in any of claims 2-10.
Cystic fibrosis (CF) is a life-threatening exocrine gland disease that is often diagnosed in childhood and its incidence tends to increase. CF affects many systems, especially the respiratory and gastrointestinal systems, and is life-threatening with its progressive course. In addition to the complications that arise due to the disease affecting many systems, the limited life expectancy and poor prognosis also bring psychological and social problems for children and their families. Especially if it is a genetically inherited disease, it may cause the parent to blame himself or herself and experience psychological problems. It is stated that in order to make it easier for children with CF and their families to cope with the negativities brought about by the disease, their psychological resilience levels should be strengthened and health professionals should encourage families to do so. Apart from increasing the level of psychological resilience, other methods that contribute to the reduction of psychological problems include yoga, meditation and laughter yoga. Laughter yoga is a series of exercises that combine gratuitous laughter with yoga breathing techniques, as well as stretching-relaxation techniques, laughter and deep breathing exercises. It is reported that laughter yoga physiologically increases breathing in the body, relaxes muscles, strengthens mental function by reducing the level of stress hormones, reduces burnout, depression and anxiety levels, positively affects the quality of life and increases psychological well-being. In this context, an intervention program was created for children with CF and their mothers, including psychological resilience training, laughter yoga, concentrated breathing exercise and meditation.
PURPOSE: To obtain an antithrombotic agent, a thrombus formation suppressing agent or a thrombus forming cause suppressing agent, consisting of a pharmaceu tically acceptable powder of a green tea leave extract obtained by a new advanced and improved production process, as an active component, and having excellent thrombus forming cause suppressing effect and stability. CONSTITUTION: This method for producing an antithrombotic agent is constituted by hot water-extracting a dried green tea leave material, a parched green tea, or a marketed green tea with water or a mixture of lower alcohols and concentrating the obtained solution after removing the insoluble materials. Then, non-polar compounds are removed by redissolving the concentrated material in water and extracting with an organic solvent. Then the obtained extract is again concentrated, separated by using a column and then concentrated to obtain a green tea extract. The antithrombotic preparations are prepared by using the green tea extract as an active ingredient, and formulated with pharmaceutically used assistants in usual methods to usual preparation forms. As the preparations, tablets, capsules, solutions, soft capsules, injections and granules are cited.
The subjects included in the experimental group will carry out a protocol of proprioception exercises. Each session will last 25 minutes, taking place during 2 sessions a week, in a period of 4 weeks. All interventions will be made before the training session.
BACKGROUND: Colorectal cancer is one of the most common forms of cancer in Norway, and typically develops from colorectal polyps. For benign colorectal polyps, endoscopic removal is recommended to avoid unnecessary surgery. This study identifies the extent of surgical treatment of benign polyps in the period 1 January 2008-31 December 2021.
MATERIAL AND METHOD: We obtained statistics from the Norwegian Patient Registry on the surgical resection of benign colorectal polyps, number of colonoscopies performed and number of patients with the diagnostic code for benign polyp in the study period. Population size from Statistics Norway was used to calculate annual incidences of the procedure.
RESULTS: The number of patients with benign polyps increased from 211 per 100 000 population to 444 per 100 000 during the study period. The number of colonoscopies increased from 9.4 per 1 000 population to 16.7 per 1 000. The number of surgical resections of benign colorectal polyps per year increased from 4.2 per 100 000 population to 6.3 per 100 000. The total number of unique patients with benign polyps in the period was 215 736, of which 2.1 % received surgical treatment, with the figures varying from 2.0 % in 2008 to 1.6 % in 2021.
INTERPRETATION: Our results show that surgical treatment of benign polyps is still widespread in Norway. This impacts on patient safety and health economics. We propose the establishment of multidisciplinary teams and enhanced endoscopic competence in Norwegian health trusts.
Viruses, antigens or purified vaccines are prepd. by fractional centrifugation of a crude virus conc. in a sterilised rotor (40-90% of vol. of rotor), spinning the rotor at 2000-5000 rev./min. and adding successively to the periphery of the rotor >=2 lots of liq of increasing density, the first being less dense than that of the virus particles but dense enough to prevent migration of the greater part of the impurities, and the density of the second being >= than that of the virus particles. Having completely filled with rotor it is accelerated to such a speed so as to separate the virus from the impurities, slowing the rotor to 2000-5000 rev./min. and introducing a liq. of density >= that of the contents of the bowl to discharge the contents through the central orifice of the rotor and collecting purified virus. Process is simple and cheap.
Nanopolystyrene (NP) and phoxim (PHO) are common environmental pollutants in aquatic systems. We evaluated the toxic effects of exposure to ambient concentrations of NP and/or PHO in the intestines of the Chinese mitten crab (Eriocheir sinensis). Our study showed that histopathological changes were observed in the intestines. Specifically, NP and/or PHO exposure increased intraepithelial lymphocytes. Furthermore, NP and/or PHO exposure induced oxidative stress, as evidenced by a significant decrease in superoxide dismutase activity (SOD), peroxidase activity (POD), and total antioxidant capacity (T-AOC). Pro-inflammatory gene expression and transcriptome analysis demonstrated that NP and/or PHO exposure induced the intestinal inflammatory response. Transcriptome results showed that NP and/or PHO exposure upregulated the NF-κB signaling pathway, which is considered a key pathway in the inflammatory response. Additionally, the expression of pro-inflammatory genes significantly increased after a single exposure to NP or PHO, but it exhibited a significant decrease after the co-exposure. The downregulation of these genes in the co-exposure group likely suggested that the co-exposure mitigated intestinal inflammation response in E. sinensis. Collectively, our findings mainly showed that NP and/or PHO exposure at ambient concentrations induces oxidative stress and inflammatory response in the intestines of E. sinensis.
In the US, increased length of life and reduced morbidity and mortality have resulted in a growing number of older adults, the demographic "time bomb" often referred to in discussions of public policy. According to the Census Bureau, the population aged 65 and over will double in size within the next 25 years. Moreover, these older adults will live healthier lives than their predecessors. While this increased length of a healthy life is an undeniable societal benefit, it brings with it a major societal problem: an epidemic of aging-related cognitive decline. The need to develop interventions to address this growing problem is urgent. Aging-related cognitive dysfunction is not diffuse; rather it targets selected brain areas, in particular the frontal lobes and the hippocampal formation. The separate but interconnected subregions of the hippocampus are differentially vulnerable to pathogenic mechanisms, including the normal aging process. A range of in vivo and post-mortem studies have converged on the dentate gyrus (DG) as the hippocampal subregion differentially targeted by the aging process. As with pathogenic processes, any intervention that improves brain function does so with regional selectivity. One such intervention is physical exercise, which has been shown to improve both frontal lobe and hippocampal function. Using a high-resolution variant of functional magnetic resonance imaging (fMRI), the investigators have demonstrated that aerobic training selectively benefitted DG function both humans and mice. In addition, improvement in DG function was associated with improved performance on a word list learning task but not in tasks conventionally thought to be frontal lobe dependent. The human part of the study had significant shortcomings, however: it was small (N = 11), lacked a control group, enrolled only young subjects (age 20-45 years), and employed only a limited neuropsychological testing battery. The overall goal of this proposal is to use the high-resolution variant of fMRI to test the hypothesis that aerobic training will induce improvements in DG function in a sample of younger (age 20-35) and older (50-65) adults, assigned randomly to an active training condition or wait list control group. The investigators will use more comprehensive neuropsychological testing to examine the relationship between changes in DG function and selected cognitive capacities. Taken together with the observation that normal aging differentially targets the DG, this research program will establish that physical exercise is an effective approach for ameliorating the insidious cognitive slide that occurs in aging. Thus, the potential significance of this application is substantial.
Sessions are aiming to neuromuscular and functional training. Each session starts with trunk muscle activation. Patients will then have to realize a neuromuscular training on Huber Motion Lab® followed by multiple exercises targeting functional stability and neuromuscular control. From the 4th session, a jump sequence will be added to the previous exercices. Exercises used in this protocol are based upon successful exercises of protocols already performed on patients with anterior cruciate ligament rupture.
<P>PROBLEM TO BE SOLVED: To efficiently produce gel particles having a uniform particle diameter without causing problems of solvents derived from a step of dispersion without carrying out the step of dispersing a raw material solution for forming the raw material solution of the gel particles into a micro-particle state in an organic solvent.  <P>SOLUTION: A method for producing the gel particles is carried out as follows. The raw material solution prepared by dissolving a polymer modified with a xanthene dye and a hydrogen donor in a hydrophilic liquid or a lipophilic liquid is irradiated with visible light to cross-link and cure the polymer in the presence of the hydrogen donor. Thereby, the gel particles are produced. In the process, the raw material solution is sprayed as droplets over the vapor phase. The resultant droplets of the raw material solution are then irradiated with visible light and made to gel.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This study delves into the correlation between the triglyceride glucose-body mass index (TyG-BMI) index upon hospital admission and clinical outcomes among this patient population. We investigated the association between TyG-BMI at hospital admission and clinical outcomes in this patient group, and analyzed data from the Medical Information Mart for Intensive Care IV database, identifying acute pancreatitis (AP) patients admitted to ICUs and stratifying them by TyG-BMI quartiles. We assessed the relationship between TyG-BMI and mortality (both in-hospital and ICU) using Cox proportional hazards regression and restricted cubic splines. The cohort included 419 patients, average age 56.34 ± 16.62 years, with a majority being male (61.58%). Hospital and ICU mortality rates were 11.93% and 7.16%, respectively. Higher TyG-BMI was positively correlated with increased all-cause mortality. Patients in the highest TyG-BMI quartile had significantly greater risks of in-hospital and ICU mortality. An S-shaped curve in the spline analysis indicated a threshold effect at a TyG-BMI of 243 for increased in-hospital mortality risk. TyG-BMI is a reliable predictor of both in-hospital and ICU mortality in severely ill AP patients, suggesting its utility in enhancing risk assessment and guiding clinical interventions for this vulnerable population.
Participants will have metabolism studies to consist of outpatient X-ray and MR measurements of bone density and body composition, metabolic testing (intravenous glucose tolerance test), and muscle and adipose tissue biopsies. Blood will also be drawn for genetic testing and for microarray studies of leukocytes. Upon completion of the above studies, the participant will begin pioglitazone therapy. Every 4 weeks throughout the drug intervention, glycemic control, lipoprotein profile, and weight will be monitored. After 12 weeks of pioglitazone therapy, the X-ray and MR measurements of body composition, the biopsies, microarray studies for leukocytes and the metabolic tests will be repeated.
In recent years advances in diagnosis/ therapy in patients with acute coronary syndromes heart failure / and renal insufficiency patients could be made. However, these diseases still associated with an increased mortality rate. The diseases affecting at the same time as the heart and the kidney contribute to the deterioration in the course of the disease. An acute or chronic functional impairment of an organ, e.g. the heart, is connected to another functional impairment, such as the kidneys. In the past, different scores to the risk and prognosis assessment have been introduced measuring many different diagnostic parameters such as E.g. age, pre-existing conditions, kidney function, heart function, and laboratory values. The scores can be used for risk assessment and treatment.

For determining the prognosis of heart and kidney-failure patients, biomarkers are analyzed. Biomarkers in the blood or urine which can provide early information on a specific course of disease are called prognostic biomarkers. In this study, prognostically relevant biomarkers for cardiovascular / renal insufficiencies will be clinically evaluated, to improve the course of assessment of such disease and to gain new insights into the typical course of congestive heart failure. This is a prerequisite to allow patients to appropriate treatment as soon as possible. An important role in heart and vascular disease can be awarded the Fibroblast growth factor 23 (FGF) 23. The height of FGF23 in the blood plasma is linked with the risk of cardiovascular events occur and the beginning of dialysis patients. FGF23 goes hand in hand with the development of heart failure or with a hospitalization as a result of heart failure.

The clinical utility of biomarkers will be examined in relation to established risk scores calculated from clinical parameters, to determine whether this biomarker of bone-heart-kidney axis can extend the forecast evaluation of patients.