anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The objective of this study is to evaluate the effectiveness and toxicity of an alternative steroid dosing regimen for patients with focal segmental glomerulosclerosis (FSGS), using a pilot study design that will enroll 20 patients. Although the literature reports variable steroid responsiveness, remission rates of up to 30-40 percent have recently been reported in nephrotic adult patients treated with daily prednisone at 1 mg/kg/day for at least 4 months, followed by a taper over 3-4 months. Such a prolonged and aggressive steroid course is fraught with significant morbidity, but this approach has been advocated by some authors because of the poor prognosis for renal survival in nephrotic patients with FSGS who do not achieve remission with steroid treatment. We plan to test an eight month course of high dose steroid therapy administered in monthly pulses instead of daily doses, for comparable efficacy in achieving remission, and for the occurrence of adverse steroid side effects. We plan to enroll patients with nephrotic syndrome due to biopsy-proven FSGS, who have either not been treated, or have responded to conventional steroid dosing regimens and relapsed. We plan to treat them with monthly oral pulses of dexamethasone (40-60 mg/d x 4 days), for 8 months. The primary endpoint will be induction of complete remission, defined as urine protein less than 300 mg/d. Patients will also be evaluated for manifestations of steroid toxicity. Patients will be seen in follow up at intervals up to 24 months following study entry. If this study suggests that remission of nephrotic syndrome can be attained with this regimen, and with an acceptable toxicity profile, we will plan a randomized controlled trial of this regimen compared with daily or alternate day oral steroids.
The present invention relates to a new leptin fragment for inhibiting the growth of cancer. This new leptin series is a leptin active fragment OB3. The OB3 has a better water solubility than that of leptin. The experimental results also proved that OB3 is beneficial to the control of energy balance and glucose stability for the mice (ob/ob) that cannot produce leptin and the mice (db/db) that have leptin gene knocked out. At the same time, it does not stimulate the proliferation of cancer cells in human cervical cancer cells, ovarian cancer cells, liver cancer cells and thyroid cancer cells, so that the new application of the medicament can inhibit cancers related to leptin, FSH and endocrine system, such as liver cancer, colon cancer, breast cancer, cervical cancer, ovarian cancer and thyroid cancer. Furthermore, the medicament can also be used to prevent gynecology-related complications such as infertility and uterine fibroids caused by FSH secretion.
The experiment used a 2x2 within-subjects design in which participants either listened to music or underwent a silent control period and either performed an active foot tapping task, or a passive control task with no movement resulting in four experimental trial types: (a) Music Active (music with tapping); (b) Music Passive (music without tapping); (c) Silence Active (silence with tapping); and (d) Silence Passive (silence without tapping). The allocation of the music excerpts to the task (active, passive) was random, and the order of the four experimental trial types was counterbalanced.
Blinatumomab IV, 5 mcg/m2/day up to 28 mcg/day (detailed dosing in protocol) continous infusion. Two 28 day courses with a two week treatment free interval in between. Blinatumomab courses replace Consolidation 1 and Consolidation 2 in the standard protocol adapted for Down syndrome patients.
Persons recovering from injuries or surgeries today generally undertake physical therapy to regain usage of their muscles, joints and other portions of their body. Unfortunately such treatments often do not fully restore the patient's function, at least within constraints of the funds available. Added costs are also incurred by patients for transportation, time off work and the like. Disclosed are systems and methods to provide greatly improved and much more cost effective physical therapy regimens utilizing an interactive approach which makes possible physical therapy at home in a controlled manner. The physical therapist using the system instructs the patient and this instruction is incorporated into an intelligent camera-based system usable by the patient in the home or workplace. Dialog may take place between the patient and therapist using the system and the internet. Other features of the system increase motivation of the patient to perform the exercises prescribed.
Prostate cancer is a heterogenous disease and recent genomic analyses have highlighted specific germline and somatic mutations and alternative driver growth signaling pathways in patients with metastatic disease. Abiraterone acetate plus prednisone (AAP) is an established standard of care for the treatment of participants with mCSPC and is included in widely accepted clinical treatment guidelines. Niraparib in combination with AAP has been approved for the treatment of BRCA-mutated Metastatic Castration-Resistant Prostate Cancer (mCRPC). Niraparib is an investigational agent in the Metastatic Castration-Sensitive Prostate Cancer (mCSPC) population. Whether the addition of niraparib to the AAP standard of care may improve initial disease control and long-term outcomes compared with AAP alone in a biomarker selected mCSPC population is being evaluated on this trial. The study will consist of 4 phases; a Prescreening Phase for biomarker evaluation for eligibility only, a Screening Phase, a Treatment Phase, and a Follow-up Phase. Efficacy evaluations include the following: tumor measurements by computed tomography (CT), magnetic resonance imaging (MRI; abdomen, chest, and pelvis), Technetium-99m (99mTc) bone scans, serum prostate sensitive antigen (PSA) evaluations, and patient reported outcomes (PROs). Safety evaluations include incidence of adverse events and clinical laboratory parameters.
Women scheduled for a colposcopic examination at GRU or CerviCusco were asked to participate in the study. Interested patients read and signed an IRB-approved Informed Consent Document (ICD) that described the study and their potential involvement. The study coordinator read and or translated the ICD to women who spoke languages other than English or Spanish (i.e. Quechua).

Pertinent disease specific demographic information was collected from each patient. Following insertion of a vaginal speculum and a one minute application of 5% acetic acid, polarized and non-polarized high resolution digital RGB images were taken of the ectocervix. Thereafter, non-polarized light colposcopy was performed as standard of care. The colposcopist derived a colposcopic impression and indicated whether a biopsy was necessary. So as not to compromise the next examination, Lugol's Iodine was not applied. Then, a polarized light colposcopy was performed. As before, the colposcopist derived an impression, indicated whether a biopsy was necessary and annotated the site of pending biopsy. Then if indicated, a minimum of one cervical biopsy was obtained from the area(s) representing the most severe colopscopic changes as seen during the non-polarized exam. The exact biopsy site was annotated.
NK1 Receptor Occupancy

In two single-blind, multiple-dose, randomized, and placebo-controlled studies, healthy young men received oral aprepitant doses of 10 mg (N=2), 30 mg (N=3), 100 mg (N=3) or 300 mg (N=5) once daily (0.08, 0.24, 0.8, and 2.4 times the maximum recommended single dose, respectively) for 14 days with 2 or 3 subjects on placebo. Both plasma aprepitant concentration and NK1 receptor occupancy in the corpus striatum by positron emission tomography were evaluated, at predose and 24 hours after the last dose. At aprepitant plasma concentrations of approximately 10 ng/mL and 100 ng/mL, the NK1 receptor occupancies were approximately 50% and 90%, respectively. The oral aprepitant regimen for CINV produced mean trough plasma aprepitant concentrations greater than 500 ng/mL in adults, which would be expected to, based on the fitted curve with the Hill equation, result in greater than 95% brain NK1 receptor occupancy. However, the receptor occupancy for either CINV or PONV dosing regimen has not been determined. In addition, the relationship between NK1 receptor occupancy and the clinical efficacy of aprepitant has not been established.

Cardiac Electrophysiology

In a randomized, double-blind, positive-controlled, thorough QTc study, a single 200 mg dose of fosaprepitant had no effect on the QTc interval. Maximum aprepitant concentrations after a single 200 mg dose of fosaprepitant were 4- and 9-fold higher than that achieved with oral aprepitant 125 mg and 40 mg, respectively. QT prolongation with the recommended oral aprepitant dosing regimens for CINV and PONV is not expected.
Group 3 will be included in the exercise program twice a week for 40 minutes for 12 weeks. Trainings are planned with one-on-one therapist.
Anterior resection with total mesorectal excision (TME) is the standard procedure for mid and low rectal cancers . A colo-rectal anastomosis under peritoneal reflection is, most of the time, protected by a temporary loop stoma to decrease the risk and severity of anastomotic morbidity. This stoma, which is intended to be temporary, appears to be permanent in 6 to 32% of cases in the literature. The main risk factor being anastomotic leakage. Two major risk factors for anastomotic leakage after colorectal surgery are " male sex " and " Body mass index ", which are responsible of a higher anatomical difficulty (Narrow pelvis and bulky mesorectal fat) Studies focused on surgical difficulties usually evaluated criteria such as, total surgery duration, blood loss or surgeon's subjective evaluation. The investigators of this retrospective study hypothesize that when a stoma,primarily intended to be temporary, is not reversed after a long (2 years) post operative delay, it all comes to surgical difficulties and that these surgical difficulties are essentially represented by anatomical constraints. Therefore, the objective of this study is to look for a statistical link between permanent stoma and intraoperative difficulty represented by pelvic anatomical constraints.
Participants with confirmed diagnosis of CLL will be observed to collect data on ibrutinib therapy to describe the effectiveness of ibrutinib and to provide a description of ibrutinib therapy and the first non-ibrutinib subsequent therapy in Cohort 1. The primary data source for this observational study will be the medical records of each enrolled participant.
Pumice stone having a specific gravity of less than 1 is prepared by mixing a pulverulent mineral abrasive, e.g. natural pumice, pulverised corundum, quartz sand or quartz flour, with an inorganic or organic binder and a gas-developing carminative, and hardening the resulting mixture. The synthetic pumice is steeped, either before or after hardening, with a detergent soln. (optionally with additn. of hand care substances, perfumes and colourants) followed by removal of the solvent. Specifically, the detergent soln. is applied to the pumice pores by immersion under superatmospheric pressure or subatmos. pressure and heating.
Smokeless Tobacco (ST) users have not been the focus of tobacco control campaigns in Minnesota. However, there are a significant number of adults in Minnesota who regularly use ST. There is a need for a low-cost cessation program that can be widely delivered to ST users who may have little or no access to conventional and/or group treatments. Self-help interventions can make a significant contribution in reaching this population. The telephone provides a unique low-cost delivery system that can expand the reach of a self-help cessation program to underserved groups of tobacco users. The primary objective is to evaluate the effectiveness of telephone-based counseling in promoting smokeless tobacco cessation among Minnesota residents. It is hypothesized that a greater proportion of individuals assigned to the telephone calling group will quit their use of smokeless tobacco products and all tobacco products compared to the comparison group not receiving calls. We plan to recruit 400 smokeless tobacco users who are interested in quitting their use of smokeless tobacco and randomize them to telephone counseling for smokeless tobacco cessation or to a comparison group that receives the same mailed self-help materials. All subjects will be assessed pre-intervention, and at 3- and 6-months.
PURPOSE:To obtain a hemorrhoid medicine not causing a special side effect such as constipation and having an excellent treating effect against the hemorrhoid. CONSTITUTION:This hemorrhoid medicine contains spherical active carbon having a particle diameter of 0.05-2.0mm, preferably 0.1-1.0mm, and preferably a specific surface area of 500-2000m<2>/g as an active ingredient. The spherical active carbon includes the particles originated from carbonaceous powder, an organic synthetic polymer, and a petroleum hydrocarbon, especially the spherical active carbon originated from the petroleum hydrocarbon. The spherical active carbon is preferably subjected to oxidation and reduction treatments. The spherical active carbon originated from the petroleum hydrocarbon is produced e.g. by forming a petroleum pitch having a pour point of 50-300 deg.C in a molten state into a small particulate shape, converting the formed particles into infusible particles with oxygen, thermally carbonizing the produced infusible particles at a temperature of 600-1000 deg.C in an inert atmosphere, and subsequently activating the carbonized particles at a temperature of 800-1000 deg.C in a stream atmosphere.
Urban rivers are hotspots of N2O production and emission. Interconnected river-lake networks are constructed to improve the water quality and hydrodynamic conditions of urban rivers in many cities of China. However, the impact of the river-lake connectivity project on N2O production and emission remains unclear. This study investigated dissolved N2O and emission of the river-lake network in Wuhan City, China from March 2021 to December 2021. The results showed that river-lake connection greatly decreased riverine Nitrogen (N) concentration and increased dissolved oxygen (DO) concentration compare to traditional urban rivers. N2O emissions from the urban river interconnected with lakes (LUR: 67.3 ± 92.6 μmol/m2/d) were much lower than those from the traditional urban rivers (UR: 467.3 ± 1075.7 μmol/m2/d) and agricultural rivers (AR: 20.4 ± 15.3μmol/m2/d). Regression tree analysis suggested that the N2O concentrations were extremely high when hypoxia exists (DO < 1.6 mg/L), and TDN was the primary factor regulating N2O concentrations when hypoxia does not occur. Thus, we ascribe the low N2O emission in the LUR and AR to the lower N contents and higher DO concentrations. The microbial process of N2O production and consumption were quantitatively estimated by isotopic models. The mean proportion of denitrification derived N2O (fbD) was 63.5 %, 55.6 %, 42.3 % and 42.7 % in the UR, LUR, lakes and AR, suggested denitrification dominated N2O production in the urban rivers, but nitrification dominated N2O production in the lakes and AR. The positive correlation between logN2O and fbD suggested that denitrification is the key process to regulate the N2O production and emission. The abundance of denitrification genes (nirS and nirK) was much higher than that of nitrification genes (amoA and amoB), also evidenced that denitrification was the main N2O source. Therefore, river-lake interconnected projects changed the nutrients level and hypoxic condition, leading to the inhibition of denitrification and nitrification, and ultimately resulting in a decrease of N2O production and emission. These results advance the knowledge on the microbial processes that regulate N2O emissions in inland waters and illustrate the integrated management of water quality and N2O emission.
Severe Acute Pancreatitis, a serious condition caused by factors such as gallstones and chronic excessive alcohol consumption, with a very high mortality rate. Human pancreatic lipase (hPL) is a key digestive enzyme and abnormal activity levels of this enzyme are important indicators for diagnosing and monitoring pancreatic diseases. A fluorescent probe, LPP, has been developed to monitor the activity of hPL, especially in cases of SAP. The probe is based on cyanine isoindole derivatives, in vitro experiments confirmed the high specificity and sensitivity of the probe, with a detection limit of 0.012 U/mL, reactions completed within 10 min, and effective monitoring of pancreatic lipase activity in various biological samples. The stability and low cytotoxicity of LPP make it suitable for clinical applications, providing new tools and perspectives for the research and treatment of pancreatic diseases and related metabolic abnormalities. In addition, the change in fluorescence lifetime after the reaction of the probe with lipase allows for fluorescence lifetime imaging (FLIM), effectively monitoring the dynamic changes of hPL and enabling early diagnosis and monitoring of pancreatitis. This research not only enhances the understanding of pancreatic lipase activity detection but also has the potential to improve the diagnostics and treatment of pancreatitis.
Ball sports demand precise control of body and ball while executing tactics and team coordination, which leads to cognitive depletion and mental fatigue. The detrimental effects of mental fatigue on physical, technical, cognitive, and tactical performance in ball sports are evident, highlighting the need for effective management of mental fatigue as a crucial component of modern sports science. This review aims to systematically study and integrate existing experiments on mental fatigue recovery interventions to identify viable strategies for mitigating its impacts. Following PRISMA guidelines, electronic databases including Web of Science, PubMed, SPORTDiscus, and Scopus were used for literature screening. Studies that induced mental fatigue followed by interventions aimed at mental fatigue recovery were included in this review, resulting in 6 articles primarily focused on basketball, soccer, and golf. Short-term interventions such as music listening, mindfulness training, self-talk, and natural visual stimuli have been shown as effective strategies to alleviate mental fatigue and enhance technical and cognitive performance in ball sports. However, their practical application in real-game environments requires further research and validation. Additionally, future research should explore defensive skills and tactical performance as viable directions for study.
One capsule will be taken (dextromethorphan HB and quinidine sulfate, 20 mg/10 mg) daily for seven days. On the eight day and for the remainder of the study 2 capsule will be taken twice a day. Medication will be taking daily for a total of 3 months.
Data will be collected from 130 patients with non-specific chronic back pain that will be recruited for a prospective cross-sectional study. To characterize the main study variables, the participants will undergo the Focused analgesia selection test (FAST) which evaluates within-subjects variability of pain reports, and placebo manipulation containing administration of an inert injection accompanied by a verbal suggestion, which is expected to produce placebo effects. The involvement of additional factors considered associated with the within-subjects variability of pain reports and the placebo response will be explored. Stress and well-being characteristics will be examined by measuring cortisol levels in saliva and in hair, salivary level of Secretory Immune globulin A (SIgA), and an autonomic nervous system function and a stress perception questionnaire. Personal traits such as suggestibility, optimism, and Focus of attention, will be examined using questionnaires. Memory will be assessed by memory task, and factors related to the pain modulation system will be examined using psychophysical tests, and a pain sensitivity questionnaire.
The intervention group (1) will use GlowCaps, a remote monitoring and reminder pill bottle; (2) assigned an engagement advisor from the study team; (3) asked to provide study team with names and contact information of up to 3 family members or friends as support partners for med adherence. The study team will contact these people in order listed until 1 agrees to this role; (4) will select a 2-digit lucky number to be used as part of the sweepstakes-based engagement incentives in which eligibility to win will be conditional on med adherence; and (5) will determine preferences for Way to Health platform communication methods.The group receiving the program intervention will also have their claims data analyzed for the 12 months post-enrollment.
Praziquantel therapy will be offered at the start, at six weeks and at 12 weeks from date of enrollment. Thereafter praziquantel therapy will be offered if subjects have demonstrable S. mansoni eggs on the subsequent six-monthly evaluations. In addition subjects will receive placebo as a supplement for two months which will be followed by antioxidant as a supplement for the rest of the year.
Fludarabine Day -6 to -2 and Cyclophosphamide Day -5 and -4. On Day 0 PNK-007 at 4 varying dose levels followed by Human recombinant Interleukin-2 (rhIL-2) every other day, Day 0 to Day 10.
Patients receive falimarev vaccine intratumorally using endoscopic ultrasound guidance on day 1. Patients also receive inalimarev vaccine SC on day 1 and sargramostim SC on days 1-4. Patients then receive falimarev vaccine SC on days 15 and 29 and sargramostim SC on days 15-18 and 29-32 in the absence of unacceptable toxicity. Beginning on day 43, patients with stable or improving pancreatic cancer receive falimarev vaccine SC and sargramostim SC (given on the day of and for 3 days after each falimarev vaccination) monthly in the absence of disease progression or unacceptable toxicity. Beginning on day 71, patients with no irreversible or dose limiting toxicity, receive falimarev vaccine SC and sargramostim SC (given on the day of and for 3 days after each falimarev vaccination) monthly in the absence of disease progression or unacceptable toxicity.
PURPOSE: Patent processus vaginalis (PPV) is usually observed in pediatric abdominal surgery; however, robotic single-port surgery in repairing processus vaginalis has not been reported in children. Herein, we present our clinical experiences in single-port robotic surgeries for PPV repair to evaluate both efficacy and safety.
METHODS: Retrospective analysis of patients underwent single-port robotic-assisted laparoscopic surgery for genitourinary diseases from May 2020 and May 2023 in our center. Among these patients, 21 children had PPV repaired at the same time. The case characteristics and follow-up data were recorded.
RESULTS: Twenty-one of the 53 children were found to have PPV during genitourinary surgery. The simultaneous treatment of the primary disease and PPV with a single-port robotic-assisted platform was both convenient and safe. There was no significant increase in total operation time, and no excessive intraoperative hemorrhage was observed in any of the operations. There were no complications observed on follow-up.
CONCLUSION: With a high incidence of PPV in children, a single-port robotic-assisted procedure is feasible and effective if simultaneously performed when addressing a primary abdominal disease.