anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The aim of the invention is to provide a new composition for the treatment of baldness and particularly for retarding and preventing hair loss. It has been discovered that thioacids, preferably thioaryl acids, such as thiobenzoic acid, reduce and prevent hair loss, particularly hair loss associated to baldness. According to the invention, a thioacid such as thiobenzoic acid is topically applied to the hair scalp, preferably in the form of a dermatologically acceptable composition. The compositions of the invention contain a mercaptocarbonyl compound, preferably a thioacid, typically thiobenzoic acid or salts or other dermatologically acceptable derivatives thereof in a quantity effective to control the hair loss, in combination with a dermatologically acceptable vehicle. In order to retard and prevent hair loss (and in some occasions to regenerate hair) there are disclosed topically applicable, dermatologically acceptable compositions, with a component which comprises a mercaptocarbonyl group or dermatologically acceptable salts thereof or a derivative thereof. One of the typical preferred compositions contains thiobenzoic acid.
A communication system utilizes an activity monitor that is operable to collect data, convert data, display data, and communicate data. Web portal and activity monitor are operable to communicate data between one another. Web portal enables a user to monitor an individual or population's activity data. Activity monitor enables user to toggle through one or more activity modes to be displayed. Activity monitor constantly measures a user's activity. Auxiliary mode enables user to track data that can be unrelated to activity data. Special event mode on activity monitor enables a user or machine to begin and to end a special event, while the activity monitor measures activity data during the special event.
<P>PROBLEM TO BE SOLVED: To save the labor for preparing operation of order information to be used to prepare a recept and a prescription for medical action, to improve the efficiency of the preparation operation and to prevent ordering errors and order input omissions as well.  <P>SOLUTION: This medical care support system 1 preliminarily stores medical treatment prearrangement information 22 and relevant information 23 in a storing part 20. An order information generating part 60 acquires from the relevant information 23 information of insurance items and insurance points corresponding to medical treatment execution information input when medical treatment action included in the medical treatment prearrangement information 22 is executed to generate order information. The generated order information is transmitted to an ordering system 3. When a medical treatment end key 2011 is clicked when medical treatment to a corresponding patient ends, the order information is transmitted to a recept system 7.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.
Patients receive anastrozole daily for 6 cycles followed by surgery. A treatment cycle is 4 weeks in length. After completion of analysis of endocrine resistant data, patients will continue treatment as defined in the protocol.
Digital Surgical Planning and Positioning Tools + ORA System with VerifEye or VerifEye +. Spherical power of the IOL will be selected using the Verion Planner with the surgeon's preferred formula with an optimized A-constant (Haigis, Holladay 2, Holladay, or other). Both toric lenses and corneal incisions will be calculated with the Verion Planner using the Verion Reference Unit keratometry and white to white measurements, and Lenstar biometry. The VERION Digital Markers L and M will be used for axis of placement and confirmed using ORA System with VerifEye or VerifEye +.
Hearing difficulty (HD) is a major health burden in older adults. While ageing-related changes in the peripheral auditory system play an important role, genetic variation associated with brain structure and function could also be involved in HD predisposition. We analysed a large-scale HD genome-wide association study (GWAS; ntotal = 501 825, 56% females) and GWAS data related to 3935 brain imaging-derived phenotypes (IDPs) assessed in up to 33 224 individuals (52% females) using multiple MRI modalities. To investigate HD pleiotropy with brain structure and function, we conducted genetic correlation, latent causal variable, Mendelian randomization and multivariable generalized linear regression analyses. Additionally, we performed local genetic correlation and multi-trait co-localization analyses to identify genomic regions and loci implicated in the pleiotropic mechanisms shared between HD and brain IDPs. We observed a widespread genetic correlation of HD with 120 IDPs in females, 89 in males and 171 in the sex-combined analysis. The latent causal variable analysis showed that some of these genetic correlations could be due to cause-effect relationships. For seven of them, the causal effects were also confirmed by the Mendelian randomization approach: vessel volume→HD in the sex-combined analysis; hippocampus volume→HD, cerebellum grey matter volume→HD, primary visual cortex volume→HD and HD→fluctuation amplitudes of node 46 in resting-state functional MRI dimensionality 100 in females; global mean thickness→HD and HD→mean orientation dispersion index in superior corona radiata in males. The local genetic correlation analysis identified 13 pleiotropic regions between HD and these seven IDPs. We also observed a co-localization signal for the rs13026575 variant between HD, primary visual cortex volume and SPTBN1 transcriptomic regulation in females. Brain structure and function may have a role in the sex differences in HD predisposition via possible cause-effect relationships and shared regulatory mechanisms.
PURPOSE:To use the titled system for simple call service and also information service widely by using plural group codes and using one for selective call service and the other for information service. CONSTITUTION:A transmitter 4 uses a selective call signal string to modulate a radio frequency signal and sends the result to air through an antenna. A receiver 5 receives a send radio selective call signal string and when a signal coincident with the selective call code assigned to the receiver 5 is detected in the string, a ring tone and message display are applied. Then the information service is inputted from a keyboard 36 while observing a display cathode ray tube (CRT) 34. In this case, as the information service, characters such as alphabets other than numerals are used. The inputted information is stored tentatively in the 2nd control 35 and when no selective call signal string is sent, the string is sent to the transmitter 4 as the information signal string through the encoder 35. When the receiver 5 receives the information signal string, all the received information is displayed in order of reception.
FIELD: medicine, particularly, pharmaceutics. SUBSTANCE: homeopathic drug contains potentiated medicinal substance where neutral carrier is introduced in the form of caramel mass. It is formed as caramel sweet with weight of 2-10 g. Homeopathic drug is prepared by introduction of potentiated medicinal solution in caramel mass in the process of caramel syrup cooling after its boiling at temperature 70-80 C in the amount of 1-3 g per 100 g of caramel mass. The prepared hard medicinal form of the homeopathic drug provides for easy administration, and increases surface and prolonged contact with mucous membrane at resorption of homeopathic caramel up to full dissolution. EFFECT: easy administration. 3 cl
Neuronal loss is the central issue in Alzheimer's disease (AD), yet no treatment developed so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal antibody (mAb2A7) against 217 site-phosphorylated human tau (p-tau217) and observed that p-tau217 levels positively correlated with brain atrophy and cognitive impairment in AD patients. Intranasal administration efficiently delivered mAb2A7 into male PS19 tauopathic mouse brain with target engagement and reduced tau pathology/aggregation with little effect on total soluble tau. Further, mAb2A7 treatment blocked apoptosis-associated neuronal loss and brain atrophy, reversed cognitive deficits, and improved motor function in male tauopathic mice. Proteomic analysis revealed that mAb2A7 treatment reversed alterations mainly in proteins associated with synaptic functions observed in murine tauopathy and AD brain. An antibody (13G4) targeting total tau also attenuated tau-associated pathology and neurodegeneration but impaired the motor function of male tauopathic mice. These results implicate p-tau217 as a potential therapeutic target for AD-associated neurodegeneration.
STUDY SUMMARY The purpose of this pilot study is to compare a medical food intervention with the dietary standard of care at Boston Medical Center, in obese women subjects undergoing Roux-en Y gastric bypass surgery. Commercially available nutritional supplements will also be provided as part of the study's protocol.

Subjects will be selected from surgical candidates of the Nutrition and Weight Management Center who meet the study criteria. Subjects will be randomly assigned to one of the 2 groups (treatment and control). Subjects will be seen at the study site 2 weeks before surgery and 4 weeks, 8 weeks, 12 weeks, and 6 months after surgery (for a total of 5 visits). Data recorded during the study visits will be used to assess post-operative progress and will include: body composition, resting energy expenditure, muscle strength, quality of life questionnaires, hair loss, and blood markers for insulin resistance, nutritional state, organ function, lipid profile and inflammation. Safety indicators and compliance will also be monitored.
Influenza vaccination is associated with a reduced incidence of cardiovascular events, cardiovascular death, and all-cause mortality. However, the functional role of the associated immunoglobulin remains unclear. This study identified a specific influenza-related immunoglobulin heavy chain junction region sequence (Ser-Leu-Gly-Ala-Ser-Asp, SD6) that inhibited plasma kallikrein (PKa) activity to resist thromboinflammatory responses and stroke injury. PKa is considered an attractive therapeutic target for alleviating the complications of thrombophilia-induced inflammation. In vitro, SD6 prolonged plasma recalcification and activated partial thromboplastin time, with no effects on bleeding risk-related prothrombin time, indicating selective inhibition of the intrinsic coagulation pathway. Correspondingly, at doses ranging from 0.25 to 4 mg/kg, SD6 attenuated arterial and cortical venous thrombosis in FeCl3-induced and photochemically induced mice, without impacting hemorrhage risk, and further mitigated cerebral inflammatory injury in a mouse model of transient middle cerebral artery occlusion ischemic stroke. These findings suggest that SD6 may serve as a potential therapeutic agent for the treatment of thromboinflammatory conditions.
Some patients with epilepsy experience seizure clusters, which may be defined as 2 or more seizures occurring within 24 hours. Left untreated, seizure clusters increase the risk for physical injury and may progress to status epilepticus, irreversible neurologic injury, and death. Rescue therapy is based on benzodiazepine treatment. Prompt, appropriate use should be specified in patients' individualized seizure action plans. Most seizure clusters occur outside the hospital setting. The ideal rescue therapy allows for easy and quick administration by a nonmedical person, which may minimize the need for intervention by emergency medical personnel or transportation to the hospital. In the 2 decades before the approval of 2 intranasal benzodiazepines in 2019 and 2020, rectal diazepam was the only route of administration approved by the US Food and Drug Administration specifically for seizure clusters. Each of the approved intranasal formulations has a unique profile. Both offer a convenient and socially acceptable route of administration. Recognition of seizure clusters and timing of proper administration are key to successful use of rescue therapy. Pharmacists' counseling plays an important role in reinforcing when and how to appropriately administer rescue therapies and the importance of consistently using rescue treatment when indicated to promote effective management. This review includes resources for pharmacists, patients, and caregivers; reviews currently available treatments; and discusses seizure action plans that support effective treatment of seizure clusters.
PROBLEM TO BE SOLVED: To produce a new compound having antagonistic actions on an excitatory amino acid receptors without adverse effects and useful for treating cerebronluronopethy or the like with the excitatory amino acid. SOLUTION: This compound is represented by formula I [Ar is a (substituted) phenyl, a (substituted)naphthyl or the like; R is nitro, cyano or the like; R<1> is H, a (halogen-substituted) lower alkyl or the like; R<2> is OH, a lower alkoxy or the like], e.g. 3,4-dihydro-6-nitro-3-oxo-7-phenylquinoxaline-2-carboxylic acid. The compound represented by formula I is obtained by reacting, e.g. a compound represented by formula II (R<7> is a lower alkyl or the like) (e.g. ethyl 3- methoxy-6-nitro-7-phenylquinoxaline-2-carboxylate) with an alkali such as potassium hydroxide in a solvent such as ethanol at 25-100 deg.C for 0.5-2 hr, providing a carboxylic acid derivative, then reacting the resultant derivative with an acid such as hydrochloric acid in the absence of presence of a solvent such as water at 25-120 deg.C for 3-96 hr.
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for cancer therapy. However, excessive pyroptosis may trigger the development of inflammatory diseases due to immoderate and continuous inflammatory reactions. Nanomaterials and nanobiotechnology, renowned for their unique advantages and diverse structures, have garnered increasing attention owing to their potential to induce pyroptosis in diseases such as cancer. A nano-delivery system for drug-induced pyroptosis in cancer cells can overcome the limitations of small molecules. Furthermore, nanomedicines can directly induce and manipulate pyroptosis. This review summarizes and discusses the latest advancements in nanoparticle-based treatments with pyroptosis among inflammatory diseases and cancer, focusing on their functions and mechanisms and providing valuable insights into selecting nanodrugs for pyroptosis. However, the clinical application of these strategies still faces challenges owing to a limited understanding of nanobiological interactions. Finally, future perspectives on the emerging field of pyroptotic nanomaterials are presented.
AIMS: Acute myocardial infarction (AMI) is a cardiovascular disease with high morbidity and mortality. We collected patients with AMI from the Medical Information Mart for Intensive Care IV (v2.0) database and explored the association between serum albumin-corrected anion gap (ACAG) level and mortality in patients with AMI.
METHODS AND RESULTS: Data of adult patients with AMI were collected. According to the 360 day prognosis, patients were divided into survival and non-survival groups. Based on the ACAG level, patients were then divided into normal and high ACAG groups. Cox hazard proportional models and restricted cubic splines (RCSs) were used to investigate the correlation between ACAG and mortality. Kaplan-Meier curves were created to compare the cumulative survival rates between the high and normal ACAG groups. The receiver operating characteristic (ROC) curve was used to analyse the predictive value of ACAG for the prognosis of patients with AMI. Sensitivity and subgroup analyses were conducted to revalidate the results. Finally, 1783 patients were included. Elevated ACAG (>20 mmol/L) was significantly associated with 30 and 360 day mortality (P < 0.001). Adjusted for multiple confounding factors, the Cox proportional hazard analysis showed that elevated ACAG (>20 mmol/L) was an independent risk factor of increased all-cause mortality in patients with AMI (hazard ratio 1.423, 95% confidence interval 1.206-1.678, P < 0.001). RCS analysis further showed that there was a non-linear trend relationship between ACAG and the risk of all-cause mortality at 30 and 360 days (χ2 = 10.750, P = 0.013; χ2 = 13.960, P = 0.003). Kaplan-Meier survival curves showed that the 30 and 360 day cumulative survival rates of patients with AMI were significantly lower (log-rank test, χ2 = 98.880, P < 0.001; χ2 = 105.440, P < 0.001) in the high ACAG group. ROC curve analysis showed that the area under the curve (AUC) of ACAG was 0.651, while the AUC of anion gap (AG) was 0.609, indicating that ACAG had a higher predictive value for 360 day mortality than AG. When combined with Sequential Organ Failure Assessment score, the predictive performance of ACAG for 360 day mortality was better, with an AUC of 0.699. Sensitivity and subgroup analyses were conducted suggesting the stability of our results.
CONCLUSIONS: Elevated serum ACAG (≥20 mmol/L) is an independent risk factor for short-term and long-term mortality in critically ill patients with AMI, and it may assist clinicians and nurses identifying high-risk patients.
Patients receiving radiotherapy for malignancies of the abdomen and pelvis will be asked to complete two research visits lasting approximately one hour. Each visit will include a 30 minute combined 4D ultrasound and 4D MRI scan.
PURPOSE:An intestinal preparation of nutrition supplement that contains specific proteins, peptides and aminoacids in a specified proportion, thus permitting the intestinal administration with no diarrhea, especially helping the normalization of the plasma aminoacid balance in hepatopathy patients. CONSTITUTION:Nitrogen compounds having the composition shown in the table, on the weight basis of the total nitrogen compounds, are used as protein sources to give the intestinal preparation of nutrition supplement that is suitably used as a nutrition supplement or remedy for hepatopathy patients such as acute hepatitis. The resultant preparation is given orally or intestinally and digested and absorbed physiologically. Further, it can lower the osmotic pressure to avoid diarrhea. It also is palatable because the bitterness and unpleasant smells characteristic in aminoacids is lowered. Since the plasma aminoacid balance in hepatopathy patients is readily normalized, the objective nutrition improvement and curing effect are sufficiently and constantly developed.
The utility model relates to hydrolat eye drops - artificial tears with antiseptic action, particularly to hydrolate eye drops - artificial tears with microbicidal, moisturizing, cleansing and antiallergic action, which finds application in medicine and in particular in ophthalmology. The hydrolat eye drops - artificial tears with antiseptic action represent a hydrolat solution obtained by distillation of fresh rose blossom - R. damascena - rose water, with a composition of 99.1 wt. % rose water and 0.9 wt. % essential extract - rose oil. The hydrolat eye drops - artificial tears with antiseptic action represent a hydrolat solution obtained by distillation of fresh rose blossom - R. damascena - rose water, with a composition of 48.2 wt. % rose water and 1.8 wt. % essential extract - rose oil and 50 wt. % hydrolates, comprising equal wt. % of: Roman chamomile, eyebright, aloe vera, basil, calendula, St. John's wort, cornflower, rosehip, bilberry, mulberry. The hydrolat eye drops - artificial tears with antiseptic action represent a hydrolat solution obtained by distillation of fresh rose blossom - R. damascena /- rose water with a composition of 48.2 wt. % rose water and 1.8 wt. % essential extract - rose oil and 50 wt. % hydrolates, comprising equal wt. of one or more of the following: Roman chamomile, eyebright, aloe vera, basil, calendula, St. John's wort, cornflower, rosehip, bilberry, mulberry. The aforementioned hydrolates may contain essential extracts of flowers, fruits, leaves and roots of the plants. The hydrolat eye drops - artificial tears with antiseptic action are easily applicable in the treatment of many eye diseases, such as dry eye syndrome, allergic and bacterial conjunctivitis, keratitis, cataracts, macular degeneration, when putting in and wearing contact lenses, and others in the field of ophthalmology.
B-cell maturation antigen (BCMA)-targeted Chimeric antigen receptor (CAR) T-cell therapy has yielded satisfactory clinical outcomes in patients with relapsed or refractory (R/R) multiple myeloma (MM). However, BCMA-targeted CAR-T cells cannot achieve a favorable response in patients with dim or negative BCMA expression on the tumor surface at baseline or relapse. G protein-coupled receptor, class C, group 5, member D (GPRC5D) is highly distributed on MM cells and proves to be a promising target for MM. In normal tissues, it is restrictedly expressed in hair follicle, rendering it a safe target for CAR-T cell therapy as well. To construct a bispecific BCMA-GPRC5D CAR structure would help mitigate the antigen escape and elevates the clinical efficacy.

This is an investigational study. The objectives are to evaluate the safety and efficacy of BCMA-GPRC5D CAR-T cells in adult patients with relapsed or refractory MM disease.
The present application relates to stabilized all-aqueous emulsions and methods of making and using the same. Described herein are methods for preparing all-aqueous emulsions, including stable emulsions and/or emulsions having high viscosity and/or ultra-low interfacial tension. The method includes mixing, combining, or otherwise contacting a first charged phase containing a first solute with at least one second phase containing a second solute. These solutes are mutually incompatible. Electrostatic forces between the two phases induce the formation of droplets of the dispersed phase in the continuous phase. The dispersed and continuous phases contain oppositely charged molecules that stabilize the droplets of the dispersed phase.