anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: In 1993, Kouvalchouk described an acromial bone block with a pedicled deltoid flap for the treatment of posterior shoulder instability. This procedure provides a "double blocking" effect in that the acromial autograft restores posterior glenoid bone loss and the deltoid flap functions as a muscular "hammock" resembling the sling effect of the conjoint in the Latarjet procedure. The primary aim of this study was to compare the Kouvalchouk procedure to distal tibial allograft (DTA) reconstruction for the management of posterior shoulder instability with associated bone loss, while the secondary aim was to evaluate the deltoid hammock effect.
METHODS: Ten upper extremity cadavers were evaluated using a validated shoulder testing apparatus in 0° and 60° of glenohumeral abduction in the scapular plane. Testing was first performed on the normal shoulder state and was followed by the creation of a 20% posterior glenoid defect. Subsequently, the Kouvalchouk and DTA procedures were conducted. Forces of 0N, 5N, 10N, and 15N were applied to the posterior deltoid tendinous insertion on the Kouvalchouk graft along the physiological muscle line-of-action to evaluate the 'hammock" effect of this procedure. Testing was additionally performed on the Kouvalchouk bone graft with the deltoid muscle sectioned from its bony attachment. For all test states, a posteriorly directed force was applied to the humeral head perpendicular to the direction of the glenoid bone defect, with the associated translation quantified using an optical tracking system. The outcome variable was posterior translation of the humeral head at an applied force magnitude of 30N.
RESULTS: The Kouvalchouk procedure with the loaded deltoid flap (10N: P = .039 and 15N: P < .001) was significantly better at reducing posterior humeral head translation than the DTA. Overall, increased glenohumeral stability was observed with increased force applied to the posterior deltoid flap in the Kouvalchouk procedure. The 15 N Kouvalchouk was most effective at preventing posterior humeral translation, and the difference was statistically significant compared with the 20% glenoid defect (P = .003), detached Kouvalchouk (P < .001), and 0N Kouvalchouk (P < .001). The 15 N Kouvalchouk procedure restored posterior shoulder joint stability to near normal levels, such that it was not significantly different from the intact state (P = .203).
CONCLUSIONS: The Kouvalchouk procedure with load applied to the deltoid was found to be biomechanically superior to the DTA for the management of posterior shoulder instability with associated bone loss. Additionally, the results confirmed the presence and effectiveness of the deltoid "hammock" effect.
One of the most important social changes today is the aging of the world's population. Along with the increasing elderly population, there is a serious increase in the number of elderly living alone. Many problems such as living alone, despair, insecurity, fear, depression, future anxiety, and close relationship longing are seen in the elderly who constitute the risk group in terms of mental health. The communication, social life and support opportunities of the elderly living alone with other people, their environment, relatives, and society are decreasing. Today, loneliness is one of the most commonly experienced psychological symptoms among the elderly. It has been reported that the feeling of loneliness is 80.0% in individuals aged 65 and over, and the age when this feeling is most common is 70 and above. Another of the most common emotions in the elderly is hopelessness. It is recommended to use art therapy, which is a supportive method suitable for a biopsychosocial approach in coping with loneliness and hopelessness. The art type, technique, and materials to be used in art therapy should be compatible with the age, ability, mental and physical development of the person to be applied. It is a substance that can be manipulated and deformed many times due to its clay structure. The person doing the clay works without fear of damaging the object due to the plastic and durable structure of the clay. Due to its advantage of being able to do it comfortably, it is a suitable art form for elderly individuals who are in the period of neurocognitive decline. Under this scope, this study will evaluate the effect of clay-based group study on the loneliness and hopelessness levels in elderly living alone.
Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined.

Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.
The invention discloses compound cinnamon capsules and a preparation method thereof and belongs to the technical field of medicines. The compound cinnamon capsules are prepared by taking Sheganzi as a main raw material and matching with auxiliary materials such as fructus perillae, semen raphani, tribulusterrestris and turnjujube. The multiple medicinal materials are compounded, so that the drug effect is promoted and improved, and the defect of single medicinal material is overcome. The product is good in mouthfeel and has obvious effect and long quality guarantee period. The Sheganzi compound capsules are scientific and effective in production process and simple and convenient to operate. Purification is performed aiming at the characteristics of different medicinal raw materials, so that the active ingredients are kept to the greatest degree, and the health requirements of different consumers can be met.
FIELD: medicine. ^ SUBSTANCE: invention refers to pharmacology. A solid pharmaceutical dispersion contains bazedoxifene acetate dispersed in a dispersant, and said dispersant contains polyvinylpyrrolidone, poloxamer, polyethylene glycol, or a mixture or copolymer of said substances. The invention refers also to the compositions containing said dispersion, to methods for making the solid pharmaceutical dispersion containing bazedoxifene acetate and the composition and a dosage form containing the solid pharmaceutical dispersion containing bazedoxifene acetate for treatment of a disease or a syndrome associated with oestrogen hunger or excess, a disease or a disorder associated with proliferation or pathological development of endometrial tissues, cholesterol reduction, bone loss inhibition and breast cancer treatment. Besides the invention covers the methods of treating mammals suffering a disease or a syndrome associated with oestrogen hunger or excess, or a disease or a disorder associated with proliferation or pathological development of endometrial tissues, or cholesterol reduction in a mammal, bone loss inhibition in a mammal or breast cancer treatment in a mammal, treatment of one or more vasomotor disorders in postmenopausal women, including the introduction of therapeutically effective amounts of the solid pharmaceutical dispersion, and also to the application of the solid pharmaceutical dispersion containing bazedoxifene acetate for preparing a drug for treatment of a disease or a syndrome associated with oestrogen hunger or excess, a disorder associated with proliferation or pathological development of endometrial tissues, cholesterol reduction, bone loss inhibition and breast cancer treatment. ^ EFFECT: invention provides higher clinical effectiveness. ^ 38 cl, 6 tbl, 2 dwg, 4 ex
Subjects requiring transfusion with red blood cells during the excision procedure after an acute burn will receive 2 units of hypoxic red blood cells manufactured with the Hemanext ONE device. As the excision treatments require transfusion of more than 2 units of red blood cells, the first 2 units transfused during the procedure will be hypoxic red blood cells. The subjects will be monitored for all adverse events through Day 28.
Bacteremia participants without pneumonia and who are not mechanically ventilated at screening will be enrolled in this cohort. Participants will receive RO7223280 on Day 1.
<P>PROBLEM TO BE SOLVED: To provide a pharmaceutical preparation composition containing a collagenous polypeptide free from risk of infection of pathogen and having high safety.  <P>SOLUTION: The pharmaceutical preparation has at least an amino acid sequence represented by the formula: Pro-Y-Gly (wherein Y is Pro or Hyp) and is composed of the collagenous synthetic polypeptide. The polypeptide may exhibit a positive Cotton effect in 220-230 nm wavelength and may exhibit a negative Cotton effect in 195-205 nm wavelength in a circular dichroism spectrum. At least one of the polypeptide may form a triple helical structure. The pharmaceutical preparation may be a solid preparation, a liquid preparation or a semi-solid preparation or a sustained release preparation.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
<P>PROBLEM TO BE SOLVED: To reduce cancer diseases.  <P>SOLUTION: Cancers growing in the body are reduced by utilizing a larva of Kisanagi (a larva of Buprestis haemorrhoidalis Herbst, etc.), growing in a hole of a tree. The larva in a nearly light red state obtained by slightly roasting the larva over a charcoal fire is considered as entirely good. The growing of the cancers in the body can be prevented by the growing of the larva in the hole of the tree.  <P>COPYRIGHT: (C)2004,JPO
Diabetic foot ulcer (DFU) prevalence is increasing in parallel with the increasing number of patients with diabetes mellitus (DM). Patients experience pain due to debridement, which is frequently used in DFU care. Therefore, it is seen that nonpharmacological strategies are needed in pain management, unlike pharmacological methods. For this purpose, this single-blind randomized controlled study attempted to provide more information to the literature for supportive care in DFU care. 68 DFU patients were included in the study. After being randomly assigned to the groups, the care solution was applied cold or hot according to the procedure in the DFU care performed in the outpatient clinic. Data were collected before (10 min before), during and after (10 min after) the procedure. Kruskal Wallis, One Way ANOVA, Post Hoc pairwise comparison tests and corrected Bonferroni were used in the analyses.
FIELD: medicine. SUBSTANCE: method involves discussing problem to be solved with a testee immediately before testing and bringing its solving necessity level to dominating level. Then Ketamine is administered to the make the testee fall into medicamentous sleep. REM-sleep stage occurrence is determined and supported within the whole study period. Rapport is set with the testee and his/her attention focus is concentrated by means of suggestion upon the problem to be solved. Problem solving is induced. Testee messages are recorded during rapport. After having obtained required information from the testee, the testee is awakened. The obtained information is analyzed. EFFECT: enhanced effectiveness in widening intellectual abilities of human being. 5 cl
The invention discloses an intelligent clothing health monitoring system and method based on deep learning. The system mainly comprises an intelligent clothing module, a deep learning algorithm module and a cloud center management module. The intelligent clothing module consists of clothing, a sensor module and a wireless communication module and is used for acquiring various vital sign data of a user and carrying out data interaction with the deep learning algorithm module. The deep learning algorithm module integrates a trained artificial intelligent model, can analyze and calculate the acquired data, and obtains a corresponding output result. The cloud center management module can interact with the deep learning algorithm module, intensively manage and store all acquired information, analyze and present the acquired information, generate corresponding data periphery or month report, and enable a user to more intuitively check the change of each vital sign data. The intelligent clothing is innovatively combined with the deep learning algorithm, the cloud center computing technology and the data preprocessing technology, the acquired information is more comprehensive, the accuracy of output results is improved, the acquisition, processing and presentation of vital sign data of a user can be realized, the processed results are fed back to the user, the abnormal vital sign information is reminded, the health of the user is effectively guaranteed, and meanwhile, the change of vital signs of the user can be reflected by the generation of weekly reports and monthly reports.
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women and transgender men. Current treatments are ineffective for a substantial proportion of patients, underscoring the need for additional therapies with long-term benefits. Nociceptors release neuropeptides, such as calcitonin gene-related peptide (CGRP), which are known to shape immunity through neuroimmune communication. Given the comorbidity between endometriosis and migraine and the integral role of immune cells and inflammation in endometriosis, we investigated the role of CGRP-mediated neuroimmune communication in endometriosis. Using samples from eight patients with endometriosis and a nonsurgical mouse model of the disease, we found that mouse and human endometriosis lesions contain both CGRP and its coreceptor, receptor activity modifying protein 1 (RAMP1). In mice, nociceptor ablation reduced pain, monocyte recruitment, and lesion size, suggesting that nociceptor activation and neuropeptide release contribute to endometriosis lesion growth and pain. Mechanistically, CGRP changed the phenotype of macrophages to a pro-endometriosis phenotype. CGRP-stimulated macrophages demonstrated impaired efferocytosis and supported increased endometrial cell growth in a RAMP1-dependent manner. Treatment of lesion-bearing mice with US Food and Drug Administration-approved drugs that block CGRP-RAMP1 signaling reduced mechanical hyperalgesia, spontaneous pain, and lesion size. Together, our data demonstrated the effectiveness and underlying cellular mechanisms of nonhormonal and nonopioid CGRP/RAMP1 blockade in a mouse model of endometriosis, suggesting that targeting this axis may lead to clinical benefit for patients with endometriosis.
OBJECTIVES: I. Determine the objective response rate in elderly patients with stage IIIB or IV non-small cell lung cancer treated with oral vinorelbine. II. Determine the time to progression in patients treated with this drug. III. Determine the toxicity of this drug in these patients. IV. Determine whether there is a perceived preference for this oral administration in these patients. V. Determine the quality of life of these patients when treated with this drug. VI. Assess individual variation in responses, pharmacokinetic parameters, and/or biological correlates in patients treated with this drug.

OUTLINE: Patients receive oral vinorelbine on days 1, 8, 15, and 22. Treatment repeats every 28 days for 4-6 courses in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline and after 8 weeks of therapy. Patients are followed every 3 months for 5 years.
A recombinant protein is prepared comprising a polypeptide of interest and a starch binding domain (SBD). The said SBD is obtainable from glucoamylase of fungi genus  Rhizopus.  The said recombinant protein comprising the said SBD can be purified by contacting with an affinity matrix such as starch, the SBD binds to the affinity matrix to isolate the recombinant protein. The recombinant protein can be purified by separating the association between the SBD and the affinity matrix by acid, alkaline, salt, or sugar. The polypeptide of interest may be an antibody, an antigen, a therapeutic compound, an enzyme, or a protein and may apply in pathogen destruction, vaccine producing, and oral care product manufacturing. The SBD further provides as a tool to screen or identify polysacchrides.
Radiomics features have been widely used as novel biomarkers in the diagnosis of various diseases, but whether radiomics features derived from hematoxylin and eosin (H&E) images can evaluate muscle atrophy has not been studied. Therefore, this study aims to establish a new biomarker based on H&E images using radiomics methods to quantitatively analyze H&E images, which is crucial for improving the accuracy of muscle atrophy assessment. Firstly, a weightless muscle atrophy model was established by laying macaques in bed, and H&E images of the shank muscle fibers of the control and bed rest (BR) macaques were collected. Muscle fibers were accurately segmented by designing a semi-supervised segmentation framework based on contrastive learning. Then, 77 radiomics features were extracted from the segmented muscle fibers, and a stable subset of features was selected through the LASSO method. Finally, the correlation between radiomics features and muscle atrophy was analyzed using a support vector machine (SVM) classifier. The semi-supervised segmentation results show that the proposed method had an average Spearman's and intra-class correlation coefficient (ICC) of 88% and 86% compared to manually extracted features, respectively. Radiomics analysis showed that the AUC of the muscle atrophy evaluation model based on H&E images was 96.87%. For individual features, GLSZM_SZE outperformed other features in terms of AUC (91.5%) and ACC (84.4%). In summary, the feature extraction based on the semi-supervised segmentation method is feasible and reliable for subsequent radiomics research. Texture features have greater advantages in evaluating muscle atrophy compared to other features. This study provides important biomarkers for accurate diagnosis of muscle atrophy.
PROBLEM TO BE SOLVED: To provide a method that makes possible determination of a specific grass allergen in a composed material.SOLUTION: To determine the presence of an extract from at least one grass species selected from perennial ryegrass, timothy grass, orchard grass, vernal grass and Kentucky bluegrass, peptide having alignment No. 1 and at least one peptide selected from a lot including alignment No. 2, alignment No. 3, alignment No. 4 and alignment No. 5 are used.SELECTED DRAWING: None
The prevalence of obesity and type 2 diabetes in the United States and worldwide has risen dramatically over the last few decades, resulting in an enormous need for new therapies to treat these conditions. The discovery that beiging of subcutaneous white adipose tissue may increase energy expenditure has led to tremendous interest in beige cells as a potential treatment for diabetes and obesity. An established treatment for type 2 diabetes and obesity is endurance exercise training. Exercise training can improve systemic homeostasis, and although adaptations to skeletal muscle play a critical role in these effects, the underlying mechanisms are not fully understood. Moreover, the contributions of other tissues in these beneficial effects of exercise on metabolism have not been intensively investigated. The study team hypothesizes that exercise training results in fundamental changes to white adipose tissue, including beiging, and these adaptations play an important role in the effects of exercise training to improve metabolic homeostasis.
Bone graft compositions and methods are provided for promoting cellular recruitment bone regeneration. The novel bone graft includes at least one of: fluorapatite nano-crystalline coated non-ceramic hydrophilic hydroxylapatite crystals; and a combination of fluorapatite nano-crystalline coated non-ceramic hydrophilic hydroxylapatite crystals and fluorapatite nano-crystalline coated hydroxylapatite crystal clusters. Methods include treating cells at a bone defect site with the novel bone graft, wherein fluorapatite crystallites from the fluorapatite nano-crystalline coating immediately and continuously release fluorapatite to the cellular environment over the course of treating the cells. The compositions and methods promote cell differentiation, migration, and proliferation. Through the use of compositions and methods provided herein, inhibition of the migration of connective tissue and epithelial cells to bone defect sites is realized for better bone restoration by osteoblast cells. Moreover, inhibition of inflammatory cells and bacteria at the surgical site are realized, further enhancing bone restoration.
The invention allows remote monitoring of measurements in clinical trials. Clinical trial participant data units received from a client device are accessed. The clinical trial participant data units are set to include a clinical trial diary entry from a clinical trial diary application in the client device and clinical trial measurement samples corresponding to the clinical trial diary entry from a measurement device connected to the client device via a short-range wireless connection. If it is determined that such a data unit lacks any collected clinical trial measurement samples, a wireless connection log is searched for a corresponding connectivity issue entry. If such an entry is found, it is determined that a potential connectivity issue exists and a connectivity correction action is triggered. Otherwise, it is determined that a potential compliance issue exists and a compliance correction action is triggered.
Consumption of alcohol mixed with energy drinks (AmED) has increased mainly among young people. Energy drinks (ED) are usually combined with alcohol with the intention of counteracting its effects. However, most studies have not shown a reduction in drunkenness and consumption is related with engagement of risk-taking behaviours like driving under alcohol effects. It is already known that alcohol concentrations and effects are higher in women than in men even after adjusting dose by weight.

The relevance of gender in the acute effects of alcohol associated with ED consumed in a binge-drinking pattern has been poorly studied. A randomized clinical trial will be conducted in healthy volunteers (1:1) and four treatment conditions will be administered: alcohol+ED, alcohol+placebo of ED, placebo of alcohol+ED and placebo of alcohol+placebo of ED. Subjective and physiological effects, driving related skills, and alcohol and caffeine concentrations will be measured along an 8-hours period. A pilot study has been conducted with the first 6 volunteers to select the alcohol doses. In the definitive study 70 g of alcohol in men and 55 g in women will be used.
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to new compounds of the general formula (I):   where Ar means phenyl, thienyl or thienyl substituted with lower alkyl, or its lower alkyl ester that inhibit enzyme glycineamidoribonucleotide formyltransferase and to a method of inhibition and proliferation of bacterial cells or higher organism. Method involves administration to host a compound (I) or its ester at effective dose. Invention relates to a method of inhibition of activity of glycineamideribonucleotide formyltransferase in vitro by effect on this enzyme with an effective dose of compound of the formula (I) or its ester. Compounds of the formula (I) are synthesized by multistage method that involves interaction of compounds of the formula (III)   with compound (IV)   in the presence of a base and producing a compound (V)   which interacts with acid in solvent and forms a compound (VI)  . The latter is reduced and obtained compound (VII)   is hydrolyzed to compound (VIII)   or a compound (VII) where R 3  - hydrogen is subjected for interaction with glutamic acid diester hydrochloride and if necessary the synthesized compound is hydrolyzed. EFFECT: improved method of synthesis, enhanced inhibitory effectiveness. 6 cl, 3 tbl, 3 ex