anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention provides a traditional Chinese medicine preparation for treatment of scrofula. The traditional Chinese medicine preparation is prepared from female plant caulis spatholobi roots, male plant caulis spatholobi roots and 60-degree sorghum liquor at certain weight ratios. The above materials are subjected to concentrated decoction, then the decoction is subjected to slag removal and filtration to obtain the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is taken orally, and has special effects in treating scrofula. The traditional Chinese medicine preparation has good curative effects in other tuberculosis. Scrofula is formed because of invasion of mycobacterium tuberculosis through oral cavities, decayed teeth, noses, throats or other pathways. In western medicine, anti-tuberculosis drugs or operative treatments are employed to treat scrofula. In traditional Chinese medicine, scrofula is generally named "luoli", also named "tanhe", if scrofula is located in necks, scrofula is usually called "lizijing" and in my place scrofula is usually called "jiuziyang". Liver qi and phlegm fire stagnate in liver and gallbladder meridians to form scrofula. Scrofula is treated by means of medicines with functions of soothing liver, nourishing blood, dispelling melancholy and reducing phlegm. But no matter traditional Chinese medicine or western medicine, curative effects are not satisfied, and until now no specific medicine comes out. The traditional Chinese medicine preparation makes up for the blank, and scrofula can be cured thoroughly.
BACKGROUND AND PURPOSE: Parathyroid carcinoma is the rarest endocrine neoplasm with very few published data discussing its imaging appearance with primary focus on ultrasound imaging features. We present our 23 years institutional experience to highlight multimodality imaging evaluation at presentation and at recurrence.
MATERIAL AND METHODS: Retrospective chart review of clinical and pathological diagnosis of parathyroid carcinoma patients presented for initial or recurrent disease management at M.D. Anderson Cancer Center between the period of January 2000 and February 2023 was performed. Imaging findings on US, CT, PET/CT, and technetium-99m sestamibi were analyzed for initial and local recurrent parathyroid carcinoma. We further assess patterns of distant recurrence and its location.
RESULTS: Twenty three patients with pathological and clinical diagnosis of initial (14 patients) or recurrent parathyroid carcinoma (14 patients) were included in this study. US findings of parathyroid carcinoma were larger lesions, increased/irregular vascularity, and non-circumscribed margins. Multiphasic CT findings of parathyroid carcinoma included an arterially enhancing lesion that is hypoenhancing relative to the thyroid and demonstrates no washout on delayed imaging. Highly suggestive findings for recurrent disease included a hypoechoic solid nodule (91.67%) with increased vascularity on ultrasound (81.8%) with corresponding enhancement on CT.
CONCLUSION: Parathyroid carcinoma is a rare malignancy often diagnosed after surgical resection. We provided CT and US imaging features that are helpful in suggesting the diagnosis of parathyroid carcinoma and detection of early local recurrence.
FIELD: biotechnology, in particular, production of eubiotic preparations. SUBSTANCE: method involves preparing ferment by cultivating bifidobacteria of Bifidibacterium bifidum, Bifidobacterium longum, Bifidobactrium infantis or Bifidobacterium adolescentis kinds in nutritive medium; introducing protective medium into it with following liophylic drying or preparing cultured milk product in liquid state by introducing sown dose of obtained ferment into pasteurized milk in an amount not exceeding 5% of volume of nutritive medium; providing repeated cultivation of mentioned kinds of bifidobacteria at temperature of 38 C plus and minus 1 C till bunching; cooling and packing product. To produce ferment or cultured milk product in liquid state, each kind of bifidobacteria is separately cultivated till obtaining of biomasses titrated to at least 10 9  CFU/ml and joined together prior to drying of ferment or prior to packing of biomass of cultivated milk product of bifidobacteria to obtain product in the form of mixture of mentioned kinds of bifidobacteria. To produce preparation for babies of up to 3-5 years, bifidobacteria of Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve or Bifidobacterium infantis kinds are used, and for teenagers or grownups - bifidobacteria of Bifidobacretium bifidum, Bifidobacterium longum and Bifidobacterium adolescentis kinds are used. Ratio of biomass of separate kinds of bifidobacteria in preparation is set in accordance with ratio of these bifidobacteria in intestines of healthy individual of definite age, obtained on the base of statistic data and regression analysis. EFFECT: improved medicinal and prophylactic properties of bifidopreparations, wider range of usage, improved compatibility with individual intestines normoflora and simplified production method by using optimum kinds of bifidobacteria in preparation. 4 cl, 1 dwg, 2 tbl, 6 ex
BACKGROUND: Rhinoplasty, a leading cosmetic surgical procedure, often involves the use of opioids for postoperative pain management. This raises concerns due to potential opioid side effects and overprescription. Liposomal bupivacaine offers a promising alternative, but its efficacy in rhinoplasty remains under-investigated. This study assesses the impact of liposomal bupivacaine on postoperative pain and opioid consumption following rhinoplasty.
METHODS: A retrospective study was conducted on patients undergoing rhinoplasty between January 2014 and September 2020. Postoperative pain scores were assessed at intervals up to 16 h, and opioid consumption was monitored. Patients were stratified into two groups: those receiving postoperative liposomal bupivacaine (Group 1) and those who did not (Group 2).
RESULTS: No significant disparities in demographics or surgical specifics were identified between groups. Group 1 consistently reported lower pain scores, notably at 30 min (1.4 vs. 3.7, p = 0.0006) and 2 h (2.2 vs. 3.38, p = 0.0417). Cumulatively, Group 1's average pain score was 2.4, significantly lower than Group 2's 3.4 (p = 0.0023). Group 1 also demonstrated reduced opioid consumption, with oxycodone and oral morphine equivalent (OME) intake being notably lower (p = 0.005 and p = 0.0428, respectively).
CONCLUSION: Liposomal bupivacaine presents as an efficacious alternative for post-rhinoplasty pain management, reducing both perceived pain and opioid consumption. While promising, the findings necessitate validation through larger, prospective studies considering the inherent limitations of this preliminary investigation. This study evaluates the efficacy of liposomal bupivacaine as a pain management strategy in postoperative care for rhinoplasty and septorhinoplasty procedures, with the potential to reduce reliance on opioids. The findings indicate that patients receiving liposomal bupivacaine experienced significantly lower pain scores postoperatively and less overall opioid consumption, thereby enhancing patient comfort and safety.
LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
BACKGROUND Pneumatosis intestinalis (PI) is an uncommon condition that is not specific to any particular disease. Currently, there is no specific clinical guideline for treating and diagnosing PI. Furthermore, there are numerous causes of PI, which makes it difficult for clinicians - internal medicine physicians as well as surgeons - to take a clinical approach to diagnosis and treatment. CASE REPORT We present 3 clinical scenarios with PI. In the first patient there was a solitary image of PI, which was treated successfully with parenteral nutrition and intravenous antibiotics, and he was discharged after 5 days. The other 2 cases, which involve gas in the hepatic portal vein (HPVG), were handled in 2 distinct ways: surgically and conservatively. One needed diagnostic laparoscopy with necrotic segmentectomy and was discharged from the hospital on postoperative day 16. The last patient, received resuscitation treatment due to severe comorbidities and inability to tolerate surgery. After 3 days, abdominal CT scan revealed no signs of remaining PI. However, the patient was terminally discharged after 7 weeks of treatment due to septic shock caused by sacrococcygeal ulcer and urinary tract infection. By drawing comparisons among these 3 scenarios, we aim to highlight certain indicators for conservative treatment success. CONCLUSIONS PI with HPVG is a sign of severe prognosis, which often requires surgical intervention. However, the decision to manage conservatively or surgically depends on the patient's condition and other criteria such as peritonitis, free fluid in the abdominal cavity, and the presence of shock. Physicians should also weigh the benefits and risks of surgical intervention in critically ill patients.
Subjects will receive standard of care for COVID-19 alone for 2 weeks. Total study duration (including the screening phase) will be approximately 4 weeks.
This research aimed to explore the impact of nodosin on lipopolysaccharide (LPS)-induced acute kidney injury (AKI) in rats. The study involved administering nodosin orally at doses of 2 and 4 mg/kg body weight orally to rats for 7 days before induction of AKI. Toward the end of the study, urine, blood, and kidneys were gathered from the rats to undergo biochemical and molecular examination after sacrificing them. Serum Scr, BUN, urine NGAL, and KIM-1 levels were significantly decreased in nodosin-treated AKI rats. Besides, nodosin administration resulted in a significant reduction in kidney MDA and 4-HNE levels. In contrast, antioxidant enzymes such as SOD, CAT, GPx, and GST levels increased, as well as Nrf2, NQO1, and HO-1 levels increased, while Keap-1 mRNA levels decreased in AKI rats. In addition, AKI rats treated with nodosin reversed excessive ferroptosis in the kidneys of LPS-induced AKI rats, as evidenced by increased mRNA and protein levels of GPX4, SLC7A11, and FTH-1. The administration of nodosin significantly reduced levels of inflammatory markers including TLR4, MYD88, NF-κB p65, IkKβ, and IL-1β, while IL-10 levels increased in the AKI-induced rats. Besides, histopathological changes were reduced in AKI-induced rats treated with nodosin. Nodosin proves highly beneficial in safeguarding the kidney from AKI by regulating oxidative stress, inflammation, and ferroptosis. The treatment of AKI could greatly benefit from this option.
The invention discloses a preparation for repairing uterus by activating ovarian function secondarily and a preparation method thereof, and belongs to the technical field of food and medicine homologous foods. The preparation is prepared into pills by taking Kaqi flower pedicle and mart as main medicines and matching with various raw materials such as rose and the like. The Kaqi flower pedicle is used for activating the vitality of ovaries, and dogwood, spina date seed and medlar are used for astringing yin and nourishing blood; wild rose, fingered citron, wrinkled gianthyssop herb, common fennel fruit and dried orange peel, and the functions of resolving depression, activating blood circulation, regulating qi and resolving dampness are realized; the mulberry, the raspberry, the lithospermum and the stir-fried fructus amomi are beneficial to absorbing new nutrients. The whole medicine has mild property, does not hurt the spirit of human body, takes blood as the root, solves the gynecopathy caused by various emotion emotions and even wind cold of women, and solves the problems by promoting blood circulation to remove blood stasis, regulating qi to promote blood circulation and warming yang to nourish, and the whole compound has the functions of astringing, resolving depression, resolving dampness, opening and closing and has inherent diarrhea. The female is easy to see the moxibustion of yin deficiency and heat, eliminates the excrescence of the waist and the abdomen, reduces the greasy degree of the face and solves various gynecological diseases. Has good effect in clinic application for many years.
A breath test for diagnosing the presence of Chlamydia species, such as Chlamydia pneumoniae, in a subject is described. The method of diagnosing Chlamydia species in a subject is performed as follows. First, a safe and effective amount of a substrate, preferably appropriately labelled, is administered to the subject. Second, the exhaled breath of the subject is analyzed to detect the concentration of a cleavage product or products, produced when an enzyme from Chlamydia bacteria cleaves the substrate. The presence of the cleavage product or products indicates a positive diagnosis of Chlamydia species in the subject. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of diagnosing Chlamydia species in a subject. For example, such a breath test kit could include a substrate to be administered to the subject.
BACKGROUND: The incidence of gallbladder diseases is as high as 20%, but whether gallbladder diseases contribute to hepatic disorders remains unknown.
METHODS: Here, we established an animal model of gallbladder dysfunction and assessed the role of a diseased gallbladder in cholestasis-induced hepatic fibrosis (CIHF).
RESULTS: Mice with smooth muscle-specific deletion of Mypt1, the gene encoding the main regulatory subunit of myosin light chain phosphatase (myosin phosphatase target subunit 1 [MYPT1]), had apparent dysfunction of gallbladder motility. This dysfunction was evidenced by abnormal contractile responses, namely, inhibited cholecystokinin 8-mediated contraction and nitric oxide-resistant relaxation. As a consequence, the gallbladder displayed impaired bile filling and biliary tract dilation comparable to the alterations in CIHF. Interestingly, the mutant animals also displayed CIHF features, including necrotic loci by the age of 1 month and subsequently exhibited progressive fibrosis and hyperplastic/dilated bile ducts. This pathological progression was similar to the phenotypes of the animal model with bile duct ligation and patients with CIHF. The characteristic biomarker of CIHF, serum alkaline phosphatase activity, was also elevated in the mice. Moreover, we observed that the myosin phosphatase target subunit 1 protein level was able to be regulated by several reagents, including lipopolysaccharide, exemplifying the risk factors for gallbladder dysfunction and hence CIHF.
CONCLUSIONS: We propose that gallbladder dysfunction caused by myosin phosphatase target subunit 1 ablation is sufficient to induce CIHF in mice, resulting in impairment of the bile transport system.
PURPOSE: A composition containing angiopoietin 1 for preventing or treating muscular atrophy or sarcopenia is provided to promote proliferation and differentiation of skeletal muscle cells and to improve intracellular calcium delivery ability. CONSTITUTION: A composition for preventing or treating muscular atrophy or sarcopenia contains angiopoietin 1 or a protein with a substantially identical physiological activity with angiopoietin 1. Angiopoietin 1 is derived from human body or a mouse. The composition additionally contains a pharmaceutically acceptable carrier. The composition is manufactured in the form of a capsule, a liquid, an injection, a soft capsule, a granule, or a tablet. [Reference numerals] (AA,CC) No treatment; (BB) 40mM caffeine; (DD) Caffeine reaction expressed by standardised rate; (EE,GG) Control group; (FF) KCI reaction expressed by standardised rate
Counseling on therapeutic lifestyle change diet consisting of 30% of energy from total fat (\<7% saturated fat, 12% monounsaturated fat and 11% polyunsaturated fat), 15% from protein and 55% from carbohydrate; less than 200 mg of cholesterol per day and 1200 mg of calcium and 2 fatty fish meals per week. Those ingesting suboptimal dietary calcium were given calcium carbonate supplementation.
The procedure will be performed under regimen of major ambulatory surgery, it will be done under guidance of combined X-ray and ultrasound. . The nerves will be located b, after applying AL (Lidocaine 1%), a RF needle will be placed in the objective position.After verifying the positive sensitive and negative motor responses the cooled radiofrequency will proceed (previous application of local anesthesia (lidocaine 2%)). Cooled RF will be performed for 2:30 minutes at 60 degrees.
The role of heat shock protein 27 (HSP27), a chaperone, in neuropathic pain after nerve injury has not been systematically surveyed despite its neuroprotective and regeneration-promoting effects. In this study, we found that HSP27 expression in sensory neurons of the dorsal root ganglia (DRG) mediated nerve injury-induced neuropathic pain. Neuropathic pain behaviors were alleviated by silencing HSP27 in the DRG of a rat spinal nerve ligation (SNL) model. Local injection of an HSP27-overexpression construct into the DRG of naïve rats elicited neuropathic pain behaviors. HSP27 interacted with a purinergic receptor, P2X3, and their expression patterns corroborated the induction and reversal of neuropathic pain according to two lines of evidence: colocalization immunohistochemically and immunoprecipitation biochemically. In a cell model cotransfected with HSP27 and P2X3, the degradation rate of P2X3 was reduced in the presence of HSP27. Such an alteration was mediated by reducing P2X3 ubiquitination in SNL rats and was reversed after silencing HSP27 in the DRGs of SNL rats. In summary, the interaction of HSP27 with P2X3 provides a new mechanism of injury-induced neuropathic pain that could serve as an alternative therapeutic target.
The present invention provides a copolymer which can be used as an oily gelling agents for preparing a stable oily gel composition. The copolymer according to the present invention is characterized by containing a hydrophobic monomer represented by the following formula (1), and a hydrophilic monomer represented by the following formula (2) and/or the following formula (3). in formula (1), R1 represents a straight or branched alkyl group having a carbon number of 16 to 22. R2 represents a hydrogen atom or a methyl group. in formula (2), R3 represents a hydrogen atom, a glyceryl group, a hydroxyalkyl group having a carbon number of 1 to 4, or a polypropylene glycol group represented by -(C3H6O)nH (n is an integer of 2 to 10), R4 represents a hydrogen atom or a methyl group. in formula (3), R5 represents a hydrogen atom or a methyl group, R6 represents a straight or branched alkyl or hydroxyalkyl group having a carbon number of 1 to 4 or a substituent represented by the following formula (4).
Low frequency (1 Hz) rTMS has shown promise to reduce cortical hyperexcitability and to improve subjective measures of sleep quality and insomnia symptoms in patients with insomnia disorder (ID) (Nardone et al. 2020). However, the few studies to date that have examined the objective measures of sleep parameters using Polysomnography (PSG), have yielded heterogeneous results. The variability in the PSG measures of sleep may potentially be attributed to the effectiveness of rTMS therapy delivered at different times of day because of changes in cortical excitability related across the 24-hour period (Ly et al. 2016) as well as the temporal proximity of the stimulation to sleep. However, the impact of the timing of rTMS administration on improving insomnia has not yet been examined. In this pilot study, the investigators aim to demonstrate the feasibility of the data acquisition using the proposed protocol and to establish preliminary data that would be used in a future R-level grant. Building on this preliminary data, the future R-level grant would be focused on optimizing rTMS therapy for insomnia and sleep quality by manipulating the time of day that the rTMS sessions are delivered. In the following, the investigators will provide their aims for this pilot study.

The investigators' objectives are 1. To assess the impact of morning versus evening administration of rTMS on a) subjective and b) objective sleep outcomes. Here the investigators propose to enroll 10 participants and randomize each to either receive 10 sessions of rTMS over two weeks in the morning or in the evening. This pilot study would provide preliminary time-of-day effects on subjective (sleep diary parameters and insomnia severity) and objective sleep (wristwatch actigraphy and PSG) measures. It characterizes the time course of improvement across the two-week treatment period for a) subjective and b) objective sleep measures. Throughout the multi-week intervention, the investigators will collect subjective and objective sleep measures to characterize the improvement across the two-week period.

Finally, this pilot study would determine whether cortical excitability predicts treatment outcomes. Participants will undergo a TMS-EEG session before rTMS therapy. Cortical excitability will be assessed by measuring TMS-evoked EEG potentials (TEP).
The study of adipose tissue (AT) is enjoying a renaissance. White, brown, and beige adipocytes are being investigated in adult animals, and the critical roles of small depots like perivascular AT are becoming clear. But the most profound revision of the AT dogma has been its cellular composition and regulation. Single-cell transcriptomic studies revealed that adipocytes comprise well under 50% of the cells in white AT, and a substantial portion of the rest are immune cells. Altering the function of AT resident leukocytes can induce or correct metabolic syndrome and, more surprisingly, alter adaptive immune responses to infection. Although the field is dominated by obesity research, conditions such as rapid lipolysis, infection, and heat stress impact AT immune dynamics as well. Recent findings in rodents lead to critical questions that should be explored in domestic livestock as potential avenues for improved animal resilience to stressors, particularly as animals age.
BACKGROUND: There are few reports on conversion surgery (CS) after chemotherapy plus nivolumab as a first-line treatment in patients with unresectable advanced or recurrent gastric cancer (GC). This multicenter study was conducted to analyze real-world data on CS after chemotherapy plus nivolumab as a first-line treatment and to identify predictive biomarkers.
METHODS: This multicenter study included 104 patients who received chemotherapy plus nivolumab as primary treatment for unresectable advanced recurrent GC from 12 institutes. We investigated and analyzed patient characteristics and blood test data in the presence or absence of CS, the relationship between the Gustave Roussy Immune Score (GRIm-s) and CS, and the characteristics of CS cases.
RESULTS: CS was performed in 12 patients (11.5%). Eastern Cooperative Oncology Group Performance Status (ECOG-PS) was significantly better in patients who underwent CS (p < 0.0001). There were no CS cases with high-risk GRIm-s (0%), however there were 22 non-CS cases (23.9%). No high-risk GRIm-s cases were converted to CS. Minimally invasive surgery was performed in 50.0% of the cases, with R0 resection in all cases and only one case of urinary retention (Grade II) as a postoperative complication, indicating a good postoperative short-term outcome. There were two cases of postoperative recurrence (16.7%), both of which were grade 1b.
CONCLUSIONS: The short-term postoperative results of CS after chemotherapy plus nivolumab as the first-line treatment for GC were acceptable in this study. There were no high-risk GRIm-s cases among those who underwent CS, suggesting that the GRIm-s may be a predictor of CS.