anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses an intelligent prediction system and method for a cerebral hemorrhage hematoma expansion risk. Preferably, the system further comprises an image comparison interpretation module. The invention designs a visual focus anatomical model map, which is convenient for dissection and focus contrast. The signs observed by the radiologist are presented in a simple, standard, easy to master procedure. The description of the focus is accurate and standard. Through comparison between the lesion description result and the preset data module, the early expansion grading of hematoma is output while the description result is output, so that a basis is provided for clinical treatment and intervention decision.
OBJECTIVE: This scoping review and meta-analysis aimed to map the evidence regarding prognostic factors in Chinese patients with immunoglobulin light chain (AL) amyloidosis and to identify current research gaps.
METHODS: We searched EMBASE, PubMed, and CNKI databases from their inception to 15 September 2021. All studies investigated the association between any prognostic factor and target outcomes, including overall survival (OS), progression-free survival (PFS), and end-stage renal disease (ESRD) in Chinese patients with AL amyloidosis.
RESULTS: This scoping review included 52 studies, of which 44 with 6,432 patients contributed to the multivariate prognostic analysis. Multivariate analysis identified a total of 106 factors that correlated with OS, 16 factors with PFS, and 18 factors with ESRD. Five prognostic factors were significantly associated with PFS, and 11 prognostic factors were significantly associated with ESRD. Meta-analysis was only available for prognostic factors without heterogeneous cutoff values, for which hazard ratios (HRs) and their 95% confidence intervals (CIs) were reported. Meta-analysis showed that bone marrow plasma cells (BMCs) (HR: 1.96, 95% CI: 1.21-3.19, p < 0.05) and interventricular septal thickness (IVST) (HR: 1.23, 95% CI: 1.10-1.38, p < 0.05) were independently associated with OS.
CONCLUSION: The significant prognostic factors associated with OS, PFS, and ESRD in Chinese patients with AL amyloidosis were related to plasma cell tumor load, biological characteristics, cardiac involvement, renal involvement, population characteristics, and treatment. Further studies should explore additional prognostic factors in patients with AL amyloidosis to develop prognostic models.
Hemay102 will be administered to patients through i.v. drip for 4hrs at the dosage of 90mg/m2.
There is substantial evidence that physical inactivity contributes to poorer physical health outcomes in older adults. There is a paucity of work examining physical activity in Veterans with PTSD. Consequently, the efficacy of exercise as a beneficial adjunctive therapy in the treatment for PTSD symptoms and related health sequelae has not been established. Methods: Approximately 50 Veterans 60 years and older with PTSD will be recruited to participate in a 12-week physical activity program consisting of aerobic and strength-training activities. Participants will be randomized to an intervention arm or usual care wait-list control. Outcomes: Changes in physical function, PTSD symptom severity, and aerobic endurance will be assessed between the two study arms. Summary: This pilot trial will extend the investigators' understanding of the physical and psychological benefits of physical activity in Veterans with PTSD. The results from this study will be used to be used to develop a larger, randomized controlled exercise trial for Veterans with PTSD. Once new, effective exercise therapies for Veterans with PTSD are established, we can augment traditional PTSD therapy with exercise therapy to promote the prevention and treatment of chronic diseases common in this vulnerable population.
This was an open, randomized, comparative multicentric, phase III study to evaluate the safety and efficacy of rhCG in comparison with urinary hCG in the induction of final follicle maturation and early luteinization in 200 Chinese female subjects undergoing superovulation. The study was organized on an outpatient basis in subjects undergoing assisted reproductive technologies (ART). All subjects underwent pituitary down- regulation per each center's normal practice prior to and during stimulation of multiple follicular development. The subjects were randomized into 2 groups. One group received rhCG 250mcg and the other group received urinary hCG (Profasi®) 10,000IU. Each subject in both groups received a single injection of hCG when the follicular development was judged to be adequate. Oocytes were retrieved 36-38 hours after the hCG injection and fertilized in vitro. Not more than 3 embryos or 2 blastocysts were to be replaced. Progesterone was administered daily according to center's normal practice, starting after the oocyte pick up and continuing until a negative pregnancy test or for the first 3 weeks of pregnancy if the subject was pregnant. The subject was followed up and the treatment outcome (negative pregnancy test or pregnancy) was recorded.

A phase I sub-study to evaluate the pharmacokinetics of single subcutaneous (s.c.) administrations of rhCG was conducted on 24 healthy Chinese female subjects in China. The subjects were randomized into 3 groups. Each group received a single dose of 250mcg or 500mcg or 750 mcg of rhCG. Blood samples were collected at predetermined intervals after the injection. Human chorionic gonadotropin serum levels were measured with the Serono MAIAclone and the in vitro bioassay MA-10. Safety was assessed by the incidence and severity of adverse events (AEs), including multiple pregnancy and ovarian hyperstimulation syndrome (OHSS) and significant changes in laboratory values.
A method for computed drafting of the variants of the individual diet comprises input of the data on the state of health of the patient, their procession, and the calculation of the diet. The "Dialog" system of decision making is used containing the computerized unit of inputting data and the channel for direct or remote data communication between the patient (or the [person who represents the patient) and/or doctor, and/or dieting expert. This unit contains the databases of formalized as well non-formalized data pertaining to the patient. The channel for data communication between the patient (or the person who represents the patient) and/or doctor, and/or dieting expert allows for the communication between the persons indicated above. The formalized data are inputted to the unit of the primary clinical and laboratory examination, then to the processing unit for calculation of the diet and drafting of the variants of the individual diet. Based on these data and the calculations of the elements of the diet, the final individual diet is drafted. Taking into account the current data on clinical and laboratory examination, the diet could be corrected or changed based on the communication between the patient (or the person who represents the patient) and/or doctor, and/or dieting expert realized by the above communication channels.
There is a lack of in-depth research on the impacts and changes in chronic psychological stress (CPS) on the cardiovascular system after acute myocardial infarction (AMI). This study aims to explore the comorbid mechanism and dynamic evolution of AMI exposed to CPS. 120 Wistar rats were randomly divided into Sham Operation group, Sham Operation + Chronic Unpredictable Mild Stress (CUMS) group, AMI group and AMI + CUMS group, with each group further divided into subgroups at days 7, 14, and 28. The AMI model was created by ligating the left anterior descending coronary artery, and CUMS model was used to induce CPS in rats. Behavioral changes were assessed through open field tests and sucrose preference tests. Cardiac function and structure were evaluated via echocardiography. The serum levels of TNFα, IL-6, NO, ET, CK-MB, cTNT, and ANP were measured using assay kits. Pathological changes in cardiac and brain tissues were observed under an optical microscope. Comparative analysis across different models revealed that CUMS significantly reduced behavioral activities in rats, with an interaction between CUMS and AMI affecting total distance (P < 0.05). Both CUMS and AMI significantly reduced cardiac function indicators, with their interaction effects on LVEF, LVFS, and CO (P < 0.05). AMI significantly altered cardiac structural parameters, particularly on day 28 (P < 0.05); while the impact of CUMS on cardiac structure was not significant, except for a notable reduction in LVAW/s on day 7 in AMI + CUMS group (P < 0.05). AMI caused significant changes in the serum biomarkers, while CUMS only significantly increased cTnT on day 7, ANP, TNFα, and IL-6 on day 14, and CK-MB on day 28, with their interaction effects on the three myocardial injury markers and TNFα (P < 0.05). Comparative analysis across different time points demonstrated that behavioral activity, cardiac function, CK-MB, cTnT, ANP, TNFα, and ET levels decreased significantly over time in the AMI model rats, while the left ventricular mass increased significantly (P < 0.05). Pathologically, compared with stress or AMI alone, the AMI + CUMS group exhibited more severe myocardia cellular degeneration and inflammatory infiltration, causing larger infract areas in myocardial tissue, as well as cell number decreases and morphological changes in hippocampal tissue. AMI with CPS exacerbates myocardial injury through sustained inflammation and endothelial dysfunction, leading to heart-brain pathology manifestations characterized by decreased cardiac function and hippocampal tissue damage.
Adult (\>18 years) patients remaining comatose during intensive care 48 hours after cardiac arrest. All patients are submitted to both clinical routine measurements: pupillometry and somatosensory evoked potentials.
The invention provides aqueous compositions and a process for dyeing hair in which naphthazarin (5, 8 dihydroxy 1, 4 naphthoquinone) is used with a water soluble surface active agent and a thickening agent.  The composition preferably contain 0.01-10% of naphthazarin, 0.25-15% of water soluble surface active agent and 0.1-20% of a thickening agent, the remainder being water, an alkaline reagent may also be included.  Dyeing is generally at temperature below 40 DEG C. and at pH values of 2.5 to 11.  Any anionic, non-ionic or cationic surface active agent may be used, and the thickening agent may be any conventional one e.g. sodium alginate, gum arabic, cellulose derivatives, acrylic and polyacrylic compounds or inorganic thickeners e.g. bentonite.  Any water soluble alkaline reagent may be employed and when used is used as 0.1 to 10% by weight of the composition, specified are aliphatic diamines and polyamines, alkanolamines and aryldialkanolamines.
An immediate and visible temporary cosmetic improvement in skin condition is obtained by a multi-stage exfoliation method having a visible end point and providing a margin of safety so that the user's skin is not significantly irritated if he or she ignores the end point and continues to carry out additional and unnecessary exfoliation steps. The preferred method involves repeatedly attaching transparent exfoliation sheets having a pressure sensitive adhesive to a selected part of the user's body and then removing each sheet by grasping one edge and pulling it across the rest of the sheet. A handle may be detachably adhered to each sheet for superior results. After each repetition the user inspects the sheet that has just been removed to monitor the amount of exfoliated tissue. When the amount of tissue on a sheet is discernibly less than that removed in the immediately previous repetition, the process is completed. Alternately, a user may compare each removed sheet with a prefabricated comparison sheet that shows a number of visually distinct regions representative of various amounts of exfoliated tissue and from this may recreate and set an individualized target end point that conforms to his or her specific desires and limitations for exfoliation. A set of precut exfoliation sheets shaped to fit a selected portion of the body may be sold in a kit that also includes a prefabricated comparison sheet, and a rod-like handle that can be attached to an edge of each of the sheets for application.
Alzheimer's disease (AD), the leading cause of dementia, presents a significant global health challenge with no known cure to date. Central to our understanding of AD pathogenesis is the β-amyloid cascade hypothesis, which underlies drug research and discovery efforts. Despite extensive studies, no animal models of AD have completely validated this hypothesis. Effective AD models are essential for accurately replicating key pathological features of the disease, notably the formation of β-amyloid plaques and neurofibrillary tangles. These pathological markers are primarily driven by mutations in the amyloid precursor protein (APP) and presenilin 1 (PS1) genes in familial AD (FAD) and by tau protein mutations for the tangle pathology. Transgenic mice models have been instrumental in AD research, heavily relying on the overexpression of mutated APP genes to simulate disease conditions. However, these models do not entirely replicate the human condition of AD. This review aims to provide a comprehensive evaluation of the historical and ongoing research efforts in AD, particularly through the use of transgenic mice models. It is focused on the benefits gathered from these transgenic mice models in understanding β-amyloid toxicity and the broader biological underpinnings of AD. Additionally, the review critically assesses the application of these models in the preclinical testing of new therapeutic interventions, highlighting the gap between animal models and human clinical realities. This analysis underscores the need for refinement in AD research methodologies to bridge this gap and enhance the translational value of preclinical studies.
In addition to postoperative routine analgesic (Acetaminophen 500mg, TID), patients were received FSN treatment. The FSN insertion point and time are the same as control group. And then we performed swaying movement and reperfusion approach.
In Arm B, 5-FU 1000 mg/m2/24 hours was administered by continuous intravenous infusion (CIV) over 120 hours (on Days 1 through 5). This regimen was repeated every 4 weeks. 5-FU CIV followed cisplatin infusion on Day 1. All 5-FU used in this study was commercially available product.
The dose is dependent upon the capacity or surface area of the structure to be irrigated and the nature of the procedure. When used as a diluent or vehicle for other drugs, the manufacturer's recommendations should be followed. For use in cell washing, the manufacturer's recommendations for blood salvaging and red cell processing should be followed.

Drug Interactions

Additives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution container permits. See PRECAUTIONS.
The present invention relates to a product which will find application as a kind of food intended for people who cannot digest the conventional one, as well as a food supplement. According to the invention, the product contains in wt. %/: lyophilized snail meat from 7 to 12, lyophilized enzyme hydrolyzate from snail meat from 2 to 6, lyophilized snail caviar from 12 to 18 and optionally lyophilized snail mucus from 0.1 to 0.3. The other components are in the following quantities /by weight %/: dextrose 45 to 55 or fructose 45 to 55, maltodextrin from 15 to 22, sodium citrate 0.4 to 0.5 and flavour 3.5 to 4.5. The product can be in powder form or capsules. The advantages provided by the product according to the invention are: the product has a beneficial effect on the recovery of patients after surgery or severe illness, as well as in malnutrition. It has an extremely good effect on the immune system and a high antioxidant effect alike. It does not contain preservatives and artificial colours. The product supports the normal functioning of the gastrointestinal tract and prevents from reflux. It has a beneficial effect on problems with the oral cavity, such as canker sores. It significantly normalizes the condition of the gums.
The present invention relates to a formulation of medicinal species or parts of extracts of one or more agents from active ingredients and pharmaceutically or cosmetically acceptable excipients. Said extract includes a high bioactive content for regenerating the skin with anti-inflammatory and healing capacities. Said formulation aims to create a pharmaceutical product effective for topical use by spraying and other therapeutic applications. Also, it comprises the first active ingredient of Camellia sinensis known as green tea, containing proteins (15-20%), amino acids (3% theanine, glutamic acid, diethylamide), carbohydrates (5%), ascorbic acid, group B vitamins, purine bases represented by caffeine (2-4%), theophylline, heterosides of triterpenes, aliphatic, and aromatic alcohols. Additionally, it contains phenolic compounds (20% or more of the dried mass of flavonoids), varying in the variety, age of the leaf (maximum in young leaf), and season (maximum in summer). Further, it obta ins a second ingredient of Aloe Barbadensis by extracting and stabilizing Aloe vera gel or juice, analyzing at least 160 components classified as vitamins, minerals, proteins, essential amino acids, and polysaccharides located in the Aloe vera leaves.
The existence of sex-specific differences in phenotypic traits is widely recognized. Yet they are often ignored in studies looking at the impact of global changes on marine organisms, particularly within the context of combined drivers that are known to elicit complex interactions. We tested sex-specific physiological responses of the cosmopolitan and ecologically important marine copepod Acartia tonsa exposed to combined hypoxia and marine heatwave (MHW) conditions, both of which individually strongly affect marine ectotherms. Females and males were acutely exposed for 5 days to a combination of either control (18°C) or a high temperature mimicking a MHW (25°C), and normoxia (100% O2 sat.) or mild hypoxia (35% O2 sat.). Life-history traits, as well as sex-specific survival and physiological traits, were measured. Females had overall higher thermal tolerance levels and responded differently than males when exposed to the combined global change drivers investigated. Females also showed lower metabolic thermal sensitivity when compared to males. Additionally, the MHW exerted a dominant effect on the traits investigated, causing a lower survival and higher metabolic rate at 25°C. However, egg production rates appeared unaffected by hypoxia and MHW conditions. Our results showed that MHWs could strongly affect copepods' survival, that combined exposure to hypoxia and MHW exerted an interactive effect only on CTmax, and that sex-specific vulnerability to these global change drivers could have major implications for population dynamics. Our results highlight the importance of considering the differences in the responses of females and males to rapid environmental changes to improve the implementation of climate-smart conservation approaches.
FIELD: food industry. ^ SUBSTANCE: mixture for baby feeding contains a source of proteins based on milk whey, casein and their mixture as well as based on soya in an amount of no more than 2.0 g/100 kcal, a source of lipids, a source of carbohydrates and a probiotic or a mixture of probiotics. The probiotic or the mixture of probiotics is/are represented by strain(s) preferably chosen from Lactobacillus and/or Bifidobacterium genus in an amount equivalent to 102-105 CFU/g of the dry mixture. The source of lipids and carbohydrates is suitable for use in baby mixtures. ^ EFFECT: possibility for application of the mixture for newborn baby immune system modulation for initiation of development of useful digestive microbiota (in the initial few weeks of baby life) comparable to microbiota of babies fed with breast milk as well as for stimulation of maturation of newborn baby immune system in the initial few weeks of baby life. ^ 12 cl, 1 tbl, 2 ex
Methods for treating latent viral infections using a gene for a nuclease that is expressed in the presence of a latent viral infection, allowing the nuclease to digest viral nucleic acid. The gene is controlled by a switch that turns expression on in the presence of viral transcripts. The switch may be an engineered sequence that, in the absence of a viral transcript, forms a duplex structure to inhibit translation. The viral transcript hybridizes to the switch and disrupts the duplex structure, allowing translation to occur. A nucleic acid encodes a nuclease and a switch that causes the nuclease to be expressed in the presence of a viral nucleic acid. A portion of the switch may be complementary to at least a portion of a latency associated transcript such as an HHV latency associated transcript that, when present, interacts with the switch to initiate translation of the nuclease.
Staff at the intervention sites were trained in basic tobacco control and motivational interviewing. Two booster trainings were held over 6 months.
In Part A, HCV GT2-infected NC participants will take GZR 100 mg + UPR 300 mg + EBR 50 mg q.d. by mouth for 8 weeks.
Liver biopsy is still used as the gold standard in the diagnosis of many liver diseases. The health practice notification (SUT) makes the diagnosis with liver biopsy mandatory for the treatment of chronic viral hepatitis (Chronic Hepatitis B Inf. And Chronic Hepatitis C Inf.). In daily gastroenterology practice, clinicians frequently perform a liver biopsy for the diagnosis of non-alcoholic fatty liver (NASH), and to a lesser extent, for the diagnosis of Wilson Disease and Hemochromatosis.

During the observation after liver biopsy, patients are hospitalized on their right side, which is the biopsy side, with the argument that there will be less bleeding or bile leakage complications. Patients who do not develop complications after 4-6 hours of observation are discharged to their homes. (1) In this study, researchers aimed to investigate the post-biopsy position of patients who were referred to the clinic for liver biopsy, the rate of complications after biopsy, and to what extent the patients found the procedure acceptable according to their post-biopsy position.
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.