anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition which is prepared from the following raw materials: clove, angelica dahurica, folium artemisiae argyi, mint, agastache rugosus, pepper, eupatorium and rhizoma atractylodis. The invention also discloses a preparation method and application of the traditional Chinese medicine composition. The Chinese medicinal composition takes pure natural Chinese medicinal herbs as raw materials, closely combines the theory of the traditional Chinese medicine with the modern extraction process technology, is scientifically compatible, is green and environment-friendly, has no toxic or side effect, and has long medicinal effect time and obvious effect. The Chinese medicinal composition takes pure natural Chinese medicinal herbs as raw materials, has no toxic or side effect, long medicinal effect time and obvious effect, and not only can refresh air, but also can refresh the brain, increase the immunity of a human body and the like. The solid aromatic has simple preparation, low preparation cost and no pollution. The Chinese medicinal composition is used as a pure Chinese medicinal aromatic solid agent, can be suitable for various people, is implemented within a certain distance range, and does not cause sensitive reaction of other people to smell.
OBJECTIVE: To determine the efficacy of a single injection of platelet-rich plasma (PRP) into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that PRP may help treat female stress urinary incontinence (SUI).
METHODS: This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous PRP or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at 6 months, defined as a negative cough stress test and an answer of "much better" or "very much better" on the Patient's Global Impression of Improvement.
RESULTS: Fifty patients were enrolled in the study and randomized to the PRP group (n = 25) or the saline placebo group (n = 25). There was no statistically significant difference in the primary outcome between the 2 groups. Adverse events were minor, and the rate of adverse events was similar between both groups.
CONCLUSION: In this randomized placebo-controlled study, we were unable to demonstrate a difference in SUI treatment success between PRP and saline injections. At this time, there is insufficient evidence to offer a one-time PRP injection into the anterior vaginal wall for treatment of female SUI.
Control Arm participants will be enrolled in the standard of care TKA program and complete six (6) research visits over 2.5-3 years. This group of participants will undergo a TKA procedure without any surgical weight loss intervention.
A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition to a tooth structure.
A device for monitoring a patient includes a substrate, an adhesive layer coupled to a first side of the substrate, and a circuit board coupled to a second side of the substrate. The adhesive layer is configured to adhere to a patient. The device also includes a plurality of switches coupled to the circuit board. Each switch is associated with a respective condition and is switchable by a user between a first state indicating that a corresponding condition is believed to be associated with the patient and a second state indicating that the corresponding condition is not believed to be associated with the patient. The device also includes a wireless transmitter coupled to the circuit board. The wireless transmitter is configured to transmit medical information associated with the patient to a mobile device. The medical information includes data indicating a setting of each of the plurality of switches.
Novel tumor-on-a-chip approaches are increasingly used to investigate tumor progression and potential treatment options. To improve the effect of any cancer treatment it is important to have an in depth understanding of drug diffusion, penetration through the tumor extracellular matrix and cellular uptake. In this study, we have developed a miniaturized chip where drug diffusion and cellular uptake in different hydrogel environments can be quantified at high resolution using live imaging. Diffusion of doxorubicin was reduced in a biomimetic hydrogel mimicking tissue properties of cirrhotic liver and early stage hepatocellular carcinoma (373 ± 108 µm2/s) as compared to an agarose gel (501 ± 77 µm2/s, p = 0.019). The diffusion was further lowered to 256 ± 30 µm2/s (p = 0.028) by preparing the biomimetic gel in cell media instead of phosphate buffered saline. The addition of liver tumor cells (Huh7 or HepG2) to the gel, at two different densities, did not significantly influence drug diffusion. Clinically relevant and quantifiable doxorubicin concentration gradients (1-20 µM) were established in the chip within one hour. Intracellular increases in doxorubicin fluorescence correlated with decreasing fluorescence of the DNA-binding stain Hoechst 33342 and based on the quantified intracellular uptake of doxorubicin an apparent cell permeability (9.00 ± 0.74 × 10-4 µm/s for HepG2) was determined. Finally, the data derived from the in vitro model were applied to a spatio-temporal tissue concentration model to evaluate the potential clinical impact of a cirrhotic extracellular matrix on doxorubicin diffusion and tumor cell uptake.
BACKGROUND AND OBJECTIVES: The incidence of stroke among young adults was rising globally, but the death burden of stroke in young adults in China is lacking. We aimed to examine the temporal trends in mortality and years of life lost (YLLs) caused by stroke among young adults from 2005 to 2020 across China.
METHODS: Based on the data from the National Mortality Surveillance System in China, we estimated the number and age-standardized rate of mortality and YLLs due to stroke and its subtypes among young adults aged 15-49 years during 2005-2020, for both China and its 31 mainland provinces.
RESULTS: During 2005-2020, the age-standardized mortality rate of stroke among young adults aged 15-49 years in China decreased by 21.0%, from 5.9/100,000 to 4.7/100,000, and the YLL rate decreased from 286.9/100,000 to 229.5/100,000. The age-standardized mortality rate among young adults due to intracerebral hemorrhage (ICH) showed a significant downward trend with a decrease of 26.3% while that of ischemic stroke (IS) and subarachnoid hemorrhage (SAH) decreased by 4.5% and 0.6%, respectively. In 2020, the mortality rate of ICH was 3.5 times higher than that of IS (3.3/100,000 vs 0.9/100,000) among young adults in China. The male/female ratio of age-standardized mortality rate of stroke in young adults increased from 2.0 in 2005 to 3.1 in 2020. The age-standardized mortality rate of IS and SAH in young men increased by 11.0% and 2.5%, respectively. In 2020, Tibet (18.4/100,000), Jilin (10.4/100,000), and Qinghai (8.3/100,000) were the top 3 provinces holding the highest age-standardized mortality rate due to stroke among young adults. Tibet was found to have the highest mortality rate due to ICH and SAH while that of IS was higher in northeast China.
DISCUSSION: In China, the death burden caused by ICH among young adults was substantially higher than that of IS. The increasing death burden of IS and SAH among young men requires special attention. Evidence-based intervention strategies are needed to improve the outcomes of stroke and alleviate the death burden due to stroke among young adults in Chinese population.
Co-occurring hazardous drinking, anxiety disorders, and PTSD are problematic combinations of mental health concerns experienced by deployed Veterans. Veterans who have been deployed are at particular risk for experiencing problems in functioning and reintegration related to mental health disorders and hazardous drinking. Co-occurring anxiety and hazardous drinking heavily impact psychosocial functioning and quality of life. Although cognitive behavior therapy (CBT) can promote psychological recovery through improvements in functioning and quality of life, most CBT protocols do not address co-occurring disorders, leading to inefficient and disjointed treatment. The current research seeks to adapt and test the Unified Protocol (UP) for deployed Veterans with hazardous drinking. The use of combined CBT for both anxiety disorders and hazardous drinking has the potential to more efficiently and effectively improve functioning, reduce symptoms, and promote psychosocial recovery.
Brain metastasis is very common, about 30% incidence rate for all patients with a diagnosis of cancer. The rising incidence of brain metastasis is most likely due to recent advances in systemic therapy, and use of magnetic resonance imaging (MRI). The most common primary site is the lung followed by breast. One of the standard treatments is whole brain radiotherapy; it can prolong the decline of neurocognitive function and improve quality of life. However, it can also cause decline in neurocognitive function as a late sequela. Memory impairment is the main cognitive function that affected by radiotherapy, and the neuronal stem cells located at hippocampal subgranular zone are highly sensitive to radiotherapy. There have been large randomized trials confirming that by HA-WBRT, the neurocognitive function decline can be reclaimed. In Taiwan, HA-WBRT is a popular and emerging treatment. However, not much study focused on its effects on neurocognitive function. The study is aimed to objectively investigate the memory preservation and neurocognitive function protection of HA-WBRT in people speaking Mandarin Chinese or Taiwanese by utilizing neurocognitive function test and QoL questionnaire.
Cannabidiol for use in the treatment of epilepsy, wherein the epilepsy is a treatment-resistant epilepsy (TRE), and wherein the TRE is Doose syndrome, is provided. Preferably the Doose syndrome is characterised by tonic-clonic seizures. Preferably the CBD is used in combination with one or more concomitant anti-epileptic drugs (AED) which may be selected from the group consisting of clobazam, levetiracetam, topiramate, stiripentol, phenobarbital, lacsamide, valproic acid, zonisamide, perampanel and fosphenytoin, wherein the dose of anti-epileptic drug/s that is/are used in combination with the CBD is reduced. Preferably the CBD is present as a highly purified extract which comprises at least 98% (w/w) CBD. Preferably the extract further comprises up to 1% CBDV (cannabidivarin) and less than 0.15% THC (tetrahydrocannabinol). Preferably the dose of CBD is from 5mg/kg/day to 25mg/kg/day. Cannabidiol (CBD) for use in the treatment of nocturnal snoring is also outlined.
<PICT:0498643/IV/1> <PICT:0498643/IV/2> Liquid pharmaceutical preparations containing surface-active material are purified or concentrated by forming froth in the liquid and removing the froth from the liquid.  If the surface-active material is an impurity in the original liquid, the latter is thus purified, while, if the surface-active material is the desired product, it is obtained in a more concentrated form when the froth is reliquified.  The liquid is treated in batches and the froth may be collected in fractions containing the surface-active materials in different degrees of concentration. Frothing agents may be added if necessary.  Air, nitrogen or other inert gas may be used to form the froth.  Agents, for example octanol, may be added to reliquefy the froth or it may be liquefied by centrifuging.  One form of suitable apparatus is shown in Fig. 3.  The liquid to be treated is supplied to a vessel a through an aperture e which is then closed by a stopper with a capillary tube b for the introduction of the gas.  The froth passes away through an aperture g and is collected in a vessel d, which can be readily changed.  The gas may be passed through a cooling coil p and separate jackets may surround the upper and lower portions of the vessel a, so that the froth can be kept at a lower temperature than the liquid.  A cooling coil o, which may be connected with the upper jacket, is provided for the froth.  Fig. 2 shows a vessel a with elongated lower portion and an upper portion dish-shaped to give a froth and liquid surface of increased area.  The method can be applied in the treatment of vegetable extracts, for example those of digitalis and ergot. Special reference is made to the treatment of a solution containing both sodium cholate and saponin, the separation of which depends on the temperature of the liquid.  The separation of saponin from a digitalis preparation is described.
A cell piercing device comprising a container, a respectively matching cap and a cell interacting surface is disclosed. The cell interacting surface comprises a plurality of extensions or prongs. The cell piercing device may further comprise a pedestal. Furthermore, a method of facilitating an interaction with the interior of cells is disclosed. The method includes the steps of loading into the container of the cell piercing device, a liquid solution containing the cells and tightening the respectively matching cap. Then centrifuging the device while the extensions or prongs protruding from the cell interacting surface are oriented essentially within the direction of the vector of the centripetal force and thereafter centrifuging the device while said extensions or prongs are oriented essentially within the direction of the vector of the centrifugal force.
IAP group: infants born to GBS-positive mothers who have received adequate intrapartum antibiotic prophylaxis (IAP). According to the Institutional treatment protocol for GBS prophylaxis (derived from CDC guidelines), intravenous ampicillin is given every 4 hours until delivery (first dose 2 g, following doses 1 g each). IAP is considered adequate when the mother received at least two doses of ampicillin before delivery.
BACKGROUND: The ongoing opioid crisis demands an investigation into the factors driving postoperative opioid use. Ambulatory robotic colectomies are an emerging concept in colorectal surgery, but concerns persist surrounding adequate pain control for these patients who are discharged very early. We sought to identify key factors affecting recovery room opioid use (ROU) and additional outpatient opioid prescriptions (AOP) after ambulatory robotic colectomies.
METHODS: This was a single-institution retrospective review of ambulatory robotic colon resections performed between 2019 and 2022. Patients were included if they discharged on the same day (SDD) or postoperative day 1 (POD1). Outcomes of interest included ROU [measured in parenteral morphine milligram equivalents (MMEs)], AOP (written between PODs 2 to 7), postoperative emergency department presentations, and readmissions.
RESULTS: Two hundred nineteen cases were examined, 48 of which underwent SDD. The mean ROU was 29.4 MME, and 8.7% of patients required AOP. Between SDD and POD1 patients, there were no differences in postoperative emergency department presentations, readmissions, recovery opioid use, or additional outpatient opioid scripts. Older age was associated with a lower ROU (-0.54 MME for each additional year). Older age, a higher body mass index, and right-sided colectomies were also more likely to use zero ROU. Readmissions were strongly associated with lower ROU. Among SDD patients, lower ROU was also associated with higher rates of AOP.
CONCLUSION: Ambulatory robotic colectomies and SDD can be performed with low opioid use and readmission rates. Notably, we found an association between low ROU and more readmission, and, in some cases, higher AOP. This suggests that adequate pain control during the postoperative recovery phase is a crucial component of reducing these negative outcomes.
PURPOSE:To make it possible to preserve and handle the titled compound useful as a gastric acid secretion inhibitor, etc. and obtain stably the titled compound, by filling a solution or suspension containing a prostaglandin, e.g. prostaglandin E, in a hard capsule. CONSTITUTION:A solution or suspension containing one or two or more prostaglandins selected from prostaglandin E (hereinafter abbreviated to PGE) and/or 15R isomer thereof is filled in a hard capsule to give the aimed stable pharmaceutical of the prostaglandin E and/or 15R isomer thereof. The above- mentioned capsule may be any one meeting the specifications of the Japanese Pharmacopoeia, and as necessary, an enteric hard capsule, etc., may be used. PGE1, 13,14-dihydro-PGE1, etc., may be cited as the PGE. The concentration of the PGE in the suspension or solution is preferably within 0.1mug/ml-100mg/ ml range.
Men with spinal cord injury (SCI) experience a high prevalence of hypogonadism which influences the neural, muscular, skeletal, and body composition deficits that occur after injury. It remains unknown whether testosterone administration improves bone mineral density, muscle mass and muscle function, and body composition / metabolic health in hypogonadal men who have experienced ambulatory dysfunction subsequent to incomplete spinal cord injury. In addition, it is unknown whether testosterone or the 5-alpha reduced metabolite dihydrotestosterone (an endogenous metabolite of testosterone) mediate effects in these and other tissues.

For this study hypogonadal men with motor incomplete spinal cord injury who present with ambulatory dysfunction will be randomized to receive testosterone plus the 5-alpha reductase inhibitor finasteride or a placebo treatment for 12 months. Testosterone or placebo injection will be administered weekly; finasteride or placebo will be administered daily. Participants will be assessed at study entry and at 1-6 month intervals thereafter. Assessments will include measurements such as a dual energy x-ray absorptiometry (DEXA) scan, MRI scan, and muscle performance tests. Participants will also have several safety tests, including electrocardiogram (EKG) for cardiac electrophysiology, prostate digital rectal exam and prostate ultrasound sizing for prostate health, and blood tests to assess hematocrit, liver enzymes (AST and ALT), prostate specific antigen (PSA), cholesterol, and other health markers.
Tramadol hydrochloride obstruction, including paralytic ileus. The tramadol in ng symptoms. Tramadol hydrochloride extended-release tablets are contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus.   
  
The tramadol in tramadol hydrochloride extended-release tablets may cause spasm of the sphincter of Oddi. Opioids may cause increases in serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis, for worsening symptoms.
BACKGROUND: Pancreatic head resection is associated with postoperative morbidity, primarily because of infectious complications. The microbiota in these infections is crucial, and selective decontamination of the digestive tract (SDD) aims to mitigate this risk by targeting pathogenic organisms while preserving beneficial flora. This study aimed to determine the effect of SDD on bacterial shifts and resistance patterns in pancreatic head resection.
METHODS: All patients who underwent pancreatic head resection either between January 2012 and August 2018 (non-SDD group) or between January 2019 and December 2021 (SDD group) were included. Propensity score-matched analysis was performed to compare the bacterial presence and resistance patterns in bile duct smear tests and postoperative complications.
RESULTS: Positive bile duct smear tests were observed more often in the non-SDD group (63.5%) than in the SDD group (51.0%). Moreover, the SDD group exhibited a significant reduction in the median number of bacterial species in the bile ducts compared with the non-SDD group (P = .04). However, a notable increase in gram-negative species was observed in the SDD group. The SDD group experienced higher rates of postoperative complications, including relevant pancreatic fistulas (24.8% in the SDD group vs 11.6% in the non-SDD group; P < .01) and delayed gastric emptying (33.8% in the SDD group vs 21.9% in the non-SDD group; P < .01). No significant difference in antibiotic resistance patterns was observed.
CONCLUSION: SDD in pancreatic head resection reduces bacterial load in the biliary tract, but it is associated with a shift toward more gram-negative species and higher rates of severe postoperative complications. Our findings suggest that SDD may negatively affect postoperative outcomes and should be carefully considered in clinical practice.
The metabolic demands created by endurance activities, which include muscle and liver glycogen depletion as well as losses in body fluids and electrolytes, are significant limitations to the performance potential of the athlete. For this reason, a well-supported recommendation exists for such athletes to consume a carbohydrate formula, in particular, one containing electrolytes during their activity.

Currently, most commercially available exercise-nutrition products for use in endurance activities come at relatively high costs to the athlete. Moreover, the ingredients used within this market vary and could therefore hinder their effectiveness. For example, Fermentable Oligosaccharides Disaccharides Monosaccharides and Polyols (FODMAPs) potentially present in common sports foods (i.e. excess fructose) are known to alter gastrointestinal (GI) function in some individuals. Indeed, 25-70% of endurance athletes experience GI symptoms during exercise. Given the prevalence of exercise induced GI discomfort in this population, it is possible that GI symptoms limit the adherence to nutritional recommendations during exercise. Therefore identification of a targeted nutrition strategy that maximizes GI effectiveness and dietary adherence is warranted.

An alternative to the commercially available sports foods are whole foods. Specifically, white potatoes, which have a high GI index, indicates that their carbohydrate content is readily available. Additionally, potatoes naturally contain potassium, an important electrolyte. Because of these characteristics, potatoes provide the potential to be a low-cost alternative, and merit investigation. To this point, we know of no studies that have explored the effectiveness of white potatoes as an ergogenic aid. Therefore, the purpose of this study is to examine how capable potatoes are at off-setting the losses in muscle and liver glycogen and electrolytes compared to the current products available on the market, i.e. "sports gels."