anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:The titled pharmaceutical consisting of an antimicrobial substance prepared by extracting a licorice or a residue after extracting a sweetness component from the licorice with an organic solvent and a specific sucrose ester of a fatty acid. CONSTITUTION:An antimicrobial pharmaceutical obtained by extracting an antimicrobial substance from a licorice or a residue after extracting a sweetness component with an aqueous solvent with an organic solvent, e.g. methanol, ethanol, acetone or dichloromethane, adsorbing the resultant extract in a basic anion exchange resin or porous resin, eluting the adsorbed substance, and incorporating 1pt.wt. resultant purified extract with 0.1-4pts.wt., preferably 0.25-2pts.wt. sucrose ester of a fatty acid, e.g. sucrose ester of stearic acid or palmitic acid, having >=5 HLB, and having improved solubility. The above-mentioned pharmaceutical exhibits very high solubility by addition thereof in the form of the pharmaceutical alone or a formulated pharmaceutical to a food, is dissolved rapidly in the food and develops effectively the antiseptic effect.
Peer support group received, in addition to usual care, peer support via telephone 1-5 times according to their own preference. Peer support was started at the time between diagnosis and the beginning of treatments.
Thirty-five million Latinos live in the U.S. and nearly 14% have peripheral arterial disease (PAD) defined as a build-up of plaque in the arteries that supply blood to the legs. Approximately 40% have at least one risk for PAD (i.e., aged 70 years and older, diabetes, high blood pressure, high blood cholesterol, or smoking). Persons with at least one risk factor and who are physically inactive are more likely to suffer from severe PAD. Physical inactivity is highly prevalent in Latinos and a major risk factor for PAD. Physical inactivity affects 50% of Latinos aged 60 years and older.

Participation in this study will last for about 3 months. Participants will be randomized to one of two groups. One group will receive text messages, brief telephone calls, and a handout. The other group will only receive the handout. The study will be looking at how the different groups respond to the different interventions used in the study.
The children in this arm will receive only child intervention curriculum (peer group activities). The child intervention includes 20 hours of facilitator-guided programming delivered in 10 sessions in a peer-group setting and aims to increase resilience by developing a number of skills including positive thinking, emotional regulation, coping, and problem solving.
<P>PROBLEM TO BE SOLVED: To provide MCH receptor antagonists.  <P>SOLUTION: In one embodiment, a new class of compounds as MCH receptor antagonists, a method for producing such compounds, a pharmaceutical composition containing ≥1 kinds of such compounds, a method for preparing a pharmaceutical formulations containing ≥1 kinds of such compounds, and a method for treating, preventing or ameliorating ≥1 kinds of diseases associated with the MCH receptor are provided. An illustrative inventive compound is represented. In one embodiment, compounds having a general structure represented by formula I are disclosed. The compounds include enantiomers, stereoisomers, rotational isomers, tautomers and prodrugs and, in addition, pharmaceutically acceptable salts and solvates of the compounds and the prodrugs.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Epilepsy affects over 50 million people globally. Electroencephalography is critical for epilepsy diagnosis, but manual seizure classification is time-consuming and requires extensive expertise. This paper presents an automated multi-class seizure classification model using EEG signals from the Temple University Hospital Seizure Corpus ver. 1.5.2. 11 features including time-based correlation, time-based eigenvalues, power spectral density, frequency-based correlation, frequency-based eigenvalues, sample entropy, spectral entropy, logarithmic sum, standard deviation, absolute mean, and ratio of Daubechies D4 wavelet transformed coefficients were extracted from 10-second sliding windows across channels. The model combines multi-head self-attention mechanism with a deep convolutional neural network (CNN) to classify seven subtypes of generalized and focal epileptic seizures. The model achieved 0.921 weighted accuracy and 0.902 weighted F1 score in classifying focal onset non-motor, generalized onset non-motor, simple partial, complex partial, absence, tonic, and tonic-clonic seizures. In comparison, a CNN model without multi-head attention achieved 0.767 weighted accuracy. Ablation studies were conducted to validate the importance of transformer encoders and attention. The promising classification results demonstrate the potential of deep learning for handling EEG complexity and improving epilepsy diagnosis. This seizure classification model could enable timely interventions when translated into clinical practice.
To determine the limits between normal and emotional anxious, thirty volunteers male's adults (GL) with age range between 20 and 50 years were recruited. None of them had any pathology associated with anxiety or psychiatric disorders, and none was drugs user or taking medication.
Wet age-related macular degeneration (wet AMD) is a primary contributor to visual impairment and severe vision loss globally, but the prevailing treatments are often unsatisfactory. The development of conventional treatment strategies has largely been based on the understanding that the angiogenic switch of endothelial cells (ECs) is mainly dictated by angiogenic growth factors. Even though treatments targeting vascular endothelial growth factor (VEGF), like ranibizumab, are widely administered, more than half of patients still exhibit inadequate or null responses, suggesting the involvement of other pathogenic mechanisms. With advances in research in recent years, it has become well recognized that EC metabolic regulation plays an active rather than merely passive responsive role in angiogenesis. Disturbances of these metabolic pathways may lead to excessive neovascularization in angiogenic diseases such as wet AMD, therefore targeted modulation of EC metabolism represents a promising therapeutic strategy for wet AMD. In this review, we comprehensively discuss the potential applications of EC metabolic regulation in wet AMD treatment from multiple perspectives, including the involvement of ECs in wet AMD pathogenesis, the major endothelial metabolic pathways, and novel therapeutic approaches targeting metabolism for wet AMD.
Patients of FZQZ Group received Fu-zheng-qu-zhuo (FZQZ) oral liquid 20ml every time, and three times a day combined with integrated therapy. The integrated therapy was same to Control Group.
BACKGROUND: The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patients is important to quickly institute the correct therapies. We performed targeted proteomics and machine learning analysis to identify novel plasma proteins of MIS-C for early disease recognition.
METHODS: A case-control study comparing the expression of 2,870 unique blood proteins in MIS-C versus SCNS patients, measured using proximity extension assays. The 2,870 proteins were reduced in number with either feature selection alone or with a prior COMBAT-Seq batch effect adjustment. The leading proteins were correlated with demographic and clinical variables. Organ system and cell type expression patterns were analyzed with Natural Language Processing (NLP).
RESULTS: The cohorts were well-balanced for age and sex. Of the 2,870 unique blood proteins, 58 proteins were identified with feature selection (FDR-adjusted P < 0.005, P < 0.0001; accuracy = 0.96, AUC = 1.00, F1 = 0.95), and 15 proteins were identified with a COMBAT-Seq batch effect adjusted feature selection (FDR-adjusted P < 0.05, P < 0.0001; accuracy = 0.92, AUC = 1.00, F1 = 0.89). All of the latter 15 proteins were present in the former 58-protein model. Several proteins were correlated with illness severity scores, length of stay, and interventions (LTA4H, PTN, PPBP, and EGF; P < 0.001). NLP analysis highlighted the multi-system nature of MIS-C, with the 58-protein set expressed in all organ systems; the highest levels of expression were found in the digestive system. The cell types most involved included leukocytes not yet determined, lymphocytes, macrophages, and platelets.
CONCLUSIONS: The plasma proteome of MIS-C patients was distinct from that of SCNS. The key proteins demonstrated expression in all organ systems and most cell types. The unique proteomic signature identified in MIS-C patients could aid future diagnostic and therapeutic advancements, as well as predict hospital length of stays, interventions, and mortality risks.
A system and method for automatically recommending ultrasound examination workflow modifications based on detected activity patterns is provided. The method includes analyzing system activity detected during performance of one or more workflows of an ultrasound examination. The method includes detecting a recurring system activity pattern over a plurality of ultrasound examinations. The method includes presenting, at a display system and based on the detecting the recurring system activity pattern, a prompt providing a recommendation to apply a macro to automate a series of system activities in response to detecting a triggering system activity. The method includes receiving a user input accepting the recommendation to apply the macro. The method includes applying the macro to automate the series of system activities in response to the detecting the triggering system activity.
Patients with relapsed/refractory lymphoma generally have few if any curative options and demonstrate poor response rates to standard salvage therapies. Novel regimens utilizing molecular targets are needed to improve outcomes in this patient population. While studies evaluating single agent small-molecule inhibitors have demonstrated activity in this setting, combinations of these drugs are generally thought to be more efficacious due to targeting separate mechanisms of action and decreased chance of developing resistance. The PD-1/PD-L1 axis is a molecular target that has been demonstrated to be up-regulated in several tumors including malignant lymphoma. Several pre-clinical studies have demonstrated the importance of this axis on clinical outcomes of patients afflicted with low grade lymphoma including FL. Targeting this axis with specific inhibitors would appear to be a rationale way to improve outcomes in patients afflicted with these diseases. PI3K inhibitors in addition to inhibiting signaling, impart changes in the immune cells in the tumor microenvironment and would appear to be a logical candidate to explore in combination with immunotherapy. Based on these preliminary data, we believe that we have justification for proceeding with our proposed phase I study to combine the PD-1 inhibitor, nivolumab, with the PI3K inhibitor, copanlisib, and the CD20 antibody, rituximab, in patients with relapsed/refractory follicular and marginal zone lymphoma. This work has the potential to provide a novel strategy to improve upon the clinical response noted in this patient population.
Bronchial asthma is a neuroendocrine disease. The development of the disease process has two stages: a) first stage - neuroendocrine; b) second stage - allergic. It is a consequence of the changes in the neuroendocrine status of the organism during the first stage. There is allergy in patients with asthma, not allergic asthma. The modern asthmatologists treat allergy, not asthma, i.e. treating the result, not the cause. The bronchial asthma has two clinical forms: a) central / sympathetic / asthma. The causes / stress, viral infections, immunizations, vaccinations, etc. / act on the structures of the central nervous system and increase the tone of the sympathetic part of the vegetative nervous system. A blocker of the sympathetic tone is ergotaminum tartaricum. b) peripheral nerve asthma or asthmatic bronchitis. The causes / bacterial infections, radiation, irritants from acetone, ammonia, etc.) act on the soft tissues of the bronchial tree and increase the tone of the parasympathetic nucleus of the vagus nerve - the endocrine glands produce a thick and sticky secretion that clogs the bronchi. A blocker of the parasympathetic is the atropine. The alternative treatment of bronchial asthma lasts about a year. For the next 20-30 years and more, the patient is healthy and efficient. 1 claim
Participants were given the LIITA3H app that tracked their visits to fast food restaurants (using the ELI feature) and they submitted pictures of their food (using the SNAP feature). However, they did not receive tailored text messages.
Customers receive intervention via technology-aided phone wellness counseling. The intensive phase lasts 13 weeks and includes 5 phone calls. The customers are able to view their change change needs and choose tasks/goals for the coaching. The independent phase lasts 13 weeks and coaching is done via a digital tool.
The present invention discloses health care tea for eliminating eye fatigue. The health care tea is mainly prepared from fructus lycii, red ginseng, cornel, common yan rhizome and rock candy according to certain weight mixture proportion. The health care tea has the efficiency of liver nourishing, kidney nourishing and eye fatigue elimination and the advantages of low cost, favourable effect, rational prescription, simple preparation, easy preservation, four season suitability, disease cure, health care, convenient drinking and good mouth feel. The health care tea is suitable for persons who longtime work before computers, persons who check characters of newspapers and periodicals and students who study hard, etc. to drink, and the presons and the students overly use eyes, and are easy to have eye fatigue. The health care tea is helpful to the health care of eyes, and is an ideal good health care drinking product.
Keloid is a disease in which fibroblasts abnormally proliferate and synthesize excessive amounts of extracellular matrix, including collagen and fibronectin, during the healing process of skin wounds, causing larger scars that exceed the boundaries of the original wound. Currently, surgical excision, cryotherapy, radiation, laser treatment, photodynamic therapy, pressure therapy, silicone gel sheeting, and pharmacotherapy are used alone or in combinations to treat this disease, but the outcomes are usually unsatisfactory. The purpose of this review is to examine whether natural products can help treat keloid disease. I introduce well-established therapeutic targets for this disease and various other emerging therapeutic targets that have been proposed based on the phenotypic difference between keloid-derived fibroblasts (KFs) and normal epidermal fibroblasts (NFs). We then present recent studies on the biological effects of various plant-derived extracts and compounds on KFs and NFs. Associated ex vivo, in vivo, and clinical studies are also presented. Finally, we discuss the mechanisms of action of the plant-derived extracts and compounds, the pros and cons, and the future tasks for natural product-based therapy for keloid disease, as compared with existing other therapies. Extracts of Astragalus membranaceus, Salvia miltiorrhiza, Aneilema keisak, Galla Chinensis, Lycium chinense, Physalis angulate, Allium sepa, and Camellia sinensis appear to modulate cell proliferation, migration, and/or extracellular matrix (ECM) production in KFs, supporting their therapeutic potential. Various phenolic compounds, terpenoids, alkaloids, and other plant-derived compounds could modulate different cell signaling pathways associated with the pathogenesis of keloids. For now, many studies are limited to in vitro experiments; additional research and development are needed to proceed to clinical trials. Many emerging therapeutic targets could accelerate the discovery of plant-derived substances for the prevention and treatment of keloid disease. I hope that this review will bridge past, present, and future research on this subject and provide insight into new therapeutic targets and pharmaceuticals, aiming for effective keloid treatment.
A method for maintaining a first physiological parameter below a predetermined threshold is provided. The method includes causing first media content to be displayed on a display device, the first media content including a first prompt to perform a first activity. The method also includes receiving data associated with the user, the data including motion data associated with movement of the user and physiological data associated with the user. The method also includes determining whether the user is performing the first activity based at least in part on the physiological data, the motion data, or both. The method also includes determining a first physiological parameter associated with the user subsequent to the first prompt based at least in part on the physiological data associated with the user. The method also includes determining whether the first physiological parameter exceeds a predetermined threshold.
PURPOSE: The study improves our understanding of the reading comprehension difficulties seen in people with aphasia. It investigates the influence of reader characteristics, including personal demographic variables, and linguistic and wider cognitive skills, on text comprehension.
METHOD: Seventy-five people with aphasia and 87 neurologically typical readers completed a test of paragraph comprehension. People with aphasia also completed background tests of language, attention, recognition memory, and executive functions. The influence of demographic variables (age, gender, and level of education) was analyzed separately in the group of people with aphasia and the typical readers using analyses of variance. In the people with aphasia, the relationship between paragraph comprehension and the language and cognitive tests was explored using correlational analyses.
RESULTS: In the typical readers, there was a significant effect of gender and level of education and a significant three-way interaction. For the people with aphasia, there were no significant effects of demographic variables. Significant positive correlations were found between performance on paragraph comprehension and each of the language tests and with tests of auditory attention, executive functions, and recognition memory for words.
CONCLUSIONS: In people with aphasia, the effects of demographic variables were overshadowed by the effect of their language difficulties. The association seen across language measures reflects the shared semantic representations across single-word, sentence, and text levels, across modalities. The study emphasizes the importance of attention, executive functions, and short-term memory in the comprehension of and memory for what we read. The contribution of both language difficulties and wider cognitive skills needs to be considered when planning intervention.
SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.24695451.
The discharge is conditional on the approval of a senior physician or the attending physician in charge. The participant will sign on a "Form for discharge and consent to receive a discharge letter, using the "Apollo" application" in which the discharge process, recommendations and contact information of the department are described. Thereafter, the patient will be discharge home and the discharge letter will be available in the app once it is written. The participant is guided to contact the department, in case the discharge letter is not received in the application up to 24 hours after discharge.
This prospective study will utilize investigational MRI sequences both in a volunteer population as well as in patients in addition to standard of care MR imaging to develop and optimize MRI sequence post-processing techniques as well as to generate preliminary and comparative data for potential clinical trials. These post-processing techniques include but are not limited to visual inspection of image quality and known anatomy, semi-quantitative analysis including the use of rating schemes, signal-to-noise-ratios and contrast-to-noise-ratios measurements for quantitative assessment, standard fitting procedures for measuring MRI parameters, and using various published methods for image post-processing. The MRI methodologies we plan to use as part of this study will allow us to obtain morphological, functional and molecular information. For the patient population: Patients receiving a standard of care 1.5 or 3T MRI will be asked by study personnel if they are interested in undergoing additional investigational imaging sequences after their standard of care imaging. If the patient agrees, he/she will remain in the same position on the MRI scanner for up to an additional 30 minutes while more images are obtained. Each patient will be imaged for no longer than 2 hours (standard of care imaging and additional investigational imaging). A routine clinical report will be generated for the clinically indicated MRI by a radiologist. Once this routine clinical MRI scan is dictated and finalized, a study team member will obtain the report via IHIS and manually remove all identifiers. This report is being obtained for comparative purposes. All the data being compared will be coded using a unique study number. For the volunteer population: Healthy volunteers recruited through the OSU Wexner Medical Center or accompanying patients to their standard of care imaging appointments at The Wright Center of Innovation will be asked by study personnel if they are interested in undergoing investigational MR imaging sequences. If the volunteer agrees, he/she will be imaged on the MRI scanner for up to 60 minutes while images are obtained. Other than the participant signing the informed consent form, no participant information or protected health information (PHI) will be recorded. Following the informed consent authorization, the participant's name will be coded using a unique study number.
The invention belongs to the field of pharmaceutical preparation, and specifically discloses a vesicle-type medication system containing metformin, and an application thereof. According to the invention, metformin is used for replacing part of ammonium in a classic ammonium ion gradient, and an ammonium gradient and/or metformin gradient in water phase inside and outside liposome is established. A novel vesicle-type medication system (comprising various liposomes) is prepared. With the trans-membrane gradient, an anti-tumor drug is actively loaded into liposome. The metformin is still retained in water phase in liposome. Therefore, the two are both encapsulated in liposome. According to the invention, a surface active substance is adopted as a basic membrane material; a solution of a guanidine-containing cationic compound is adopted as a hydration medium, and blank vesicles are prepared; and trans-membrane gradient is established upon the blank vesicles, so that the medication system is prepared. The vesicle-type medication system is characterized by wide drug loading range, high drug encapsulation efficiency, and good stability. With the vesicle-type medication system, drug toxicity can be reduced, and tumor reoccurrence can be inhibited.