anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a traditional Chinese medicine product, and especially relates to mulberry leaf fluid decoction tablets and a preparation method thereof. The invention belongs to the technical field of traditional Chinese medicine. The decoction tablets are prepared with the steps that: a, medicine materials are crushed, wherein mulberry leaf traditional decoction tablets or trimmed and selected mulberry leaves are crushed; the material is sieved by using a sieve of 60-100 meshes, such that medicine powder is obtained; b, tablet preparation is carried out, wherein the medicine powder is poured into a micro air tabletting machine; the pressure in the micro air tabletting machine is regulated to 6-15kgf/cm<2>, and the powder is pressed into primary large tablets with a size of 16-20mm; the primary large tablets are crushed in a swing crusher, and the particles are sieved and trimmed, such that particles with a size of 60-100 meshes are obtained; the tablets with the size of 60-100 meshes are added into the tabletting machine; the pressure is adjusted to 4-8 kgf/cm<2>, and a pressing time is 3-7min; 0.2-0.6g of medicine powder is added, such that tablets with a size of 5-12mm are obtained. Therefore, the tablet-shaped mulberry leaf fluid decoction tablets are obtained. With the method, the prepared mulberry leaf fluid decoction tablets have uniform size and uniform density. With the method, treatment effect and characteristics of traditional Chinese medicine prescriptions are maintained.
BACKGROUND: During aging, both the brain and the immune system undergo a progressive impairment of physiological functions. Microglia, the immunocompetent cells of the central nervous system, shift towards a chronic mild inflammatory state that impacts brain homeostasis. Extracellular vesicles (EVs) released by microglia transport packages of molecular information that mirror the inflammatory status of donor cells and modulate the inflammatory phenotype of recipient microglia and other cell types.
RESULTS: We demonstrated that intranasal administration of EVs derived from microglial-like BV2 cells to late adult mice (16-20 months of age) shifts microglia toward a "juvenile" morphology affecting their inflammatory profile. Mice treated with BV2-derived EVs have a reduction of anxiety-like behavior and an increased spatial learning, with sex-dependent differences. Further, BV2-derived EVs increased neuronal plasticity both in male and female mice. These findings suggest the involvement of microglial cells in vesicles-mediated anti-aging effect.
CONCLUSIONS: Our data indicate that BV2-derived EVs could represent a resource to slow down age-dependent inflammation in the mouse brain.
OBJECTIVES: Arrhythmia is an important component of cardiovascular disease, and electrocardiogram (ECG) is a method to detect arrhythmia. Arrhythmia detection is often paroxysmal, and ECG signal analysis is time-consuming and expensive. We propose a model and device for convenient monitoring of arrhythmia at any time.
METHODS: This work proposes a model combining residual block and bidirectional long-term short-term memory network (BiLSTM) to detect and classify ECG signals. Residual blocks can extract deep features and avoid performance degradation caused by convolutional networks. Combined with the feature of BiLSTM to strengthen the connection relationship of the local window, it can achieve a better classification and prediction effect.
RESULTS: Model optimization experiments were performed on the MIT-BIH Atrial Fibrillation Database (AFDB) and MIT-BIH Arrhythmia Database (MITDB). The accuracy simulation results on both long and short signal was higher than 99 %. To further demonstrate the applicability of the model, validation experiments were conducted on MIT-BIH Normal Sinus Rhythm Database (NSRDB) and the Long-Term AF Database (LTAFDB) datasets, and the related recognition accuracy were 99.830 and 91.252 %, respectively. Additionally, we proposed a portable household detection system including an ECG and a blood pressure detection module. The detection accuracy was higher than 98 % using the collected data as testing set.
CONCLUSIONS: Hence, we thought our system can be used for practical application.
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1. NLRP7 was also found to promote progesterone receptor (PR) activity. So, the investigators hypothesized that NLRP7 may regulate progesterone-induced decidualization of human endometrial stromal cells. Part I is to explore how NLRP7 is induced during the decidualization. According to the luciferase activities of NLRP7 promoter luciferase reporter systems, the region from -100 to +37 or from -1200 to -100 had positive or negative regulatory elements, respectively, in the in vitro decidualization. Part II is to explore how NLRP7 contributes the decidualization of endometrial stromal cells. By immunoprecipitations of NLRP7 or PR, the investigators found NLRP7 might involve in the transcriptional complex of PR in the in vitro decidualization. The NLRP7 interacting protein in the co-immunoprecipitations the investigatorsre analyzed by LC/MS-MS. Part III is to explore the effects of NLRP7 mutations on in vitro decidualization and macrophage differentiation. Comparing to RFP control, the investigators found wild-type NLRP7 enhanced but NLRP7 mutants reduced IGFBP-1 expression in the in vitro decidualization. In the M1 macrophage differentiation of THP-1, wild-type and mutant NLRP7 reduced IL-1β expression compared to the RFP control. Part IV is to explore a role of MPA in macrophage differentiation. MPA drives THP-1 cells a M2-like macrophage differentiation toward a phenotype of decidual macrophages, which promoted in vitro decidualization and trophoblastic invasion, but tolerated TLR ligands stimulations. In conclusion, NLRP7 contributes in vitro decidualization of endometrial stromal cells; NLRP7 mutation may impede in vitro decidualization; NLRP7 may suppress IL-1 expression in M1 macrophage differentiation; MPA drives M2 macrophage differentiation toward a phenotype of decidual macrophage.
Participants will receive placebo as an IM injection Q3W for up to 9 doses plus Pembrolizumab 400 mg via an IV infusion Q6W for 9 cycles (up to \~54 weeks). Each cycle is 6 weeks.
This group (n = 20) received sham surgery with a steel frame affixed to their heads and four burr holes drilled into their foreheads without crossing the blood/brain barrier. Participants were assessed at baseline, 4, 8, and 12 months after surgery.
BACKGROUND: Recent studies have demonstrated a strong association between acute kidney injury (AKI) and chronic kidney disease (CKD), while the unresolved inflammation is believed to be a driving force for this chronic transition process. As a transmembrane pattern recognition receptor, Mincle (macrophage-inducible C-type lectin, Clec4e) was identified to participate in the early immune response after AKI. However, the impact of Mincle on the chronic transition of AKI remains largely unclear.
METHODS: We performed single-cell RNA sequencing (scRNA-seq) with the unilateral ischemia-reperfusion (UIR) murine model of AKI at days 1, 3, 14 and 28 after injury. Potential effects and mechanism of Mincle on renal inflammation and fibrosis were further validated in vivo utilizing Mincle knockout mice.
RESULTS: The dynamic expression of Mincle in macrophages and neutrophils throughout the transition from AKI to CKD was observed. For both cell types, Mincle expression was significantly up-regulated on day 1 following AKI, with a second rise observed on day 14. Notably, we identified distinct subclusters of Minclehigh neutrophils and Minclehigh macrophages that exhibited time-dependent influx with dual peaks characterized with remarkable pro-inflammatory and pro-fibrotic functions. Moreover, we identified that Minclehigh neutrophils represented an "aged" mature neutrophil subset derived from the "fresh" mature neutrophil cluster in kidney. Additionally, we observed a synergistic mechanism whereby Mincle-expressing macrophages and neutrophils sustained renal inflammation by tumor necrosis factor (TNF) production. Mincle-deficient mice exhibited reduced renal injury and fibrosis following AKI.
CONCLUSION: The present findings have unveiled combined persistence of Minclehigh neutrophils and macrophages during AKI-to-CKD transition, contributing to unresolved inflammation followed by fibrosis via TNF-α as a central pro-inflammatory cytokine. Targeting Mincle may offer a novel therapeutic strategy for preventing the transition from AKI to CKD.
A supervised 12-week rehabilitation program, initiated two weeks post surgery, containing 24 group-based exercise sessions, three individual counseling sessions, and three group-based lessons in health-promoting behavior. If the participants have special needs in terms of smoking cessation, nutritional counseling or patient education, this is offered too.
The value of SE testing as an indicator of outcome will be assessed in patients with resting moderate mitral regurgitation (effective regurgitant orifice 0.2-0.39 cm2, and regurgitant volume 30-59 ml) of ischemic origin and angiographically documented CAD, and will enter a regular clinical follow-up program with annotation of cardiovascular and non-cardiovascular endpoints. Patients undergoing CABG with or without mitral repair or PCI with or without mitral valve intervention will be separately analyzed. A sample size of 173 patients per arm (CABG or PCI) is required. The primary hypothesis is that patients with moderate mitral regurgitation worsening of ≥ 1 grade during exercise have worse outcome on medical therapy and greater benefit from valve correction. The secondary hypothesis is that patients with worse SE pre-surgery parameters will have worse prognosis independent of regurgitation severity and treatment (medical therapy or valve repair).
STUDY OBJECTIVES Objective The objective of this study is to conduct a sham controlled randomized trial to evaluate the efficacy and safety of the Endobar System for the treatment of obesity. Efficacy, Safety, and secondary outcomes will be evaluated at 6 and 12 months to allow expansion of the investigation into a larger, pivotal clinical study.

Study Design This is a prospective randomized, single blind, active treatment and sham controlled, single-center trial . After the informed consent and screening process are completed, all subjects who are eligible and wish to participate in the study will undergo baseline testing. Those who complete baseline testing will be randomized to either Endobar Therapy (ET) or Sham Treatment (ST) for 52 weeks. Both groups will be given lifestyle therapy for weight loss, which involves treatment with a behavioral education weight loss program delivered as 19 individual sessions in person over 52 weeks. Endobar Therapy involves catheter-based embolization of the left gastric artery. After 26 weeks, the ET group will continue to be monitored for an addition 26 weeks and the ST subjects will be given ET and monitored for 26 weeks. The duration of the entire study will be 52 weeks.
PROBLEM TO BE SOLVED: To provide a composition including a weak preservative for inhibiting microbial growth in a media and a strong preservative for inhibiting microbial growth in the composition contained in a container having a dispensing tip which the media moves, not including any preservative that stimulates the organism, and the composition can be dispensed little by little. SOLUTION: A composition including a weak preservative and a strong preservative is contained in a container 12 made of plastics and having a small head 20. A media 26 is contained in the small head 20. The weak preservative inhibits the microbial growth of the media 26 and the strong preservative inhibits the microbial growth in the composition. And, while the composition passes through the small head 20, the media 26 does not completely remove the weak preservative, but makes the strong preservative inactive or remove it out. By this manner, while the composition passes through the small head 20, the strong preservative is removed, so it does not make bad influences on the organism, but the weak preservative is remained in the dispensed composition.
Background and Objective: Interatrial block (IAB) is defined as a conduction delay between the right and left atria. No data are available about the prevalence of both partial IAB and advanced IAB among the different stages of chronic kidney disease. The aim of this study was to describe the prevalence and type of advanced IAB across the spectrum of renal function, including patients on dialysis and the clinical characteristics associated with advanced IAB. Materials and Methods: Retrospective, single-center study of 151 patients consecutively admitted to the Nephrology and Ophthalmology Unit for 3 months. The study population was divided into three groups according to stages of chronic kidney disease. We evaluated the prevalence and pattern of IAB among the groups and the clinical characteristics associated with advanced IAB. Results: The prevalence of partial IAB was significantly lower in end-stage kidney disease (ESKD) group compared to control group (36.7% vs. 59.6%; p = 0.02); in contrast the prevalence of advanced IAB was significantly higher in both chronic kidney disease (CKD) (17.8% vs. 5.3%, p = 0.04) and ESKD group (24.5% vs. 5.3%, p = 0.005) compared to control group. The atypical pattern of advanced IAB was more frequent in both the ESKD and CKD group than in the control group (100% and 75% vs. 33.3%; p = 0.02). Overall, among patients that showed advanced IAB, 17 (73.9%) showed an atypical pattern by morphology and 2 (8.7%) showed an atypical pattern by duration of advanced IAB. The ESKD group was younger than the control group (65.7 ± 12.3 years vs. 71.3 ± 9.9 years; p = 0.01) and showed a higher prevalence of beta blockers (42.9% vs. 19.3%; p = 0.009), as in the CKD group (37.8% vs. 19.3%; p= 0.04). Conclusions: The progressive worsening of renal function was associated with an increasing prevalence of advanced IAB. Advanced IAB may be a sign of uremic cardiomyopathy and may suggest further evaluation with long-term follow-up to investigate its prognostic significance in chronic kidney disease.
Diarrhea is the second major source of ill health and pediatric death globally. It accounts for over 90% of loss of life in infants especially those below 5 years old in developing nations. Lack of quality water and good sanitation is the principal root of diarrhea. Poor nutritional status also increases the incidence of diarrhea. The United Nations Sustainable Development Goal (SDG) number 3 targets to put a stop to avoidable deaths among newborns and infants under 5 years old by the year 2030. Interestingly, SDG number 6 targets to ensure all-round and fair access to safe quality portable water, good sanitation, and proper hygiene for everyone by the year 2030. Unfortunately, South Asia and sub-Saharan African regions are centers of limited improved water and good sanitation facilities, thus explaining the increased morbidity and loss of life orchestrated by diarrhea in young children in these areas. Therefore, enhancing water quality, good sanitation, and proper hygiene is a pivotal interposition strategy to improve children's health and well-being and achieve SDG 3, especially in the fight against diarrhea. Due to the interrelated relationship between the SDGs, improving water quality, sanitation, and hygiene (SDG 6) appears to be the foundation for achieving other goals such as reducing malnutrition (SDG 2), eradicating poverty in children (SDG 1), building good working conditions (SDG 8), protecting the environment and climatic variations (SDG 13).
Patients in ICU with severe sepsis, both gender, adult, over 18 years od age. Initiation of renal replacement therapy after 48 hours after reaching criteria of severe sepsis.
1. Technical Result Increase in therapeutic and prophylaxis effect.         2. Essence Anatoxin comprises inactivated toxines of serotipes Clostridium botulinium - A, B, C, D, E, F and G and pharmaceutically acceptable auxiliary means thereof. In order to receive the mentioned anatoxin the strains of each serotipe is separately propagated, the obtained mass is decanting and filtered to isolate toxin. The filtrate is passed through biogel and the obtained toxin is inactivated. Further, the inactivated toxin of each serotipe is combined and diluted.         3. Field of Application Medicine.
BACKGROUND: The research aims to explore the characteristics of intestinal flora, nutritional status and immune function in patients with different types of obese colon cancer.
METHODS: A retrospective analysis is conducted on 64 cases of obese colon cancer diagnosed from June 2018 to January 2020. According to the histological staging of the cancer, they are classified into adenocarcinoma, adenosquamous carcinoma and undifferentiated carcinoma, with corresponding cases of 24, 22 and 18, respectively. The intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI), immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) are analyzed in the different groups of patients. Survival curves are evaluated by Kaplan-Meier method and log-rank test for tumour death, local recurrence, and distant metastasis.
RESULTS: There were no statistically significant differences in intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI) and immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) between different groups. There was a significant correlation between intestinal flora, nutritional status and immune function for all three. The survival curves of tumour death, local recurrence and distant metastasis in different groups of obese colon cancer patients were statistically significant. The tumor mortality rate, local recurrence, and distant metastasis rate in adenocarcinoma were 78.65%, 54.25% and 48.26% respectively.
CONCLUSION: There are differences in intestinal flora, nutritional status and immune function among different types of obese colon cancer patients, but adenocarcinoma has the least benefit in intestinal flora, poor nutritional status, and weakest immune function.
Cetuximab will be combined with weekly irinotecan and cisplatin. Patients will receive cetuximab 400 mg/m2 on day 1, week 1. Following this loading dose, patients will receive weekly cetuximab 250 mg/m2 (day 8, 15, 22, etc.) until disease progression or unacceptable toxicity. Patients will continue to receive irinotecan and cisplatin weekly on day 1 and day 8, on an every 21 day cycle. The standard maximum doses are irinotecan 65 mg/m2 and cisplatin 30 mg/m2.
Captopril tablets, USP are indicated for the treatment of hypertension.

In using captopril tablets, consideration should be given to the risk of neutropenia/agranulocytosis (see WARNINGS).

Captopril tablets may be used as initial therapy for patients with normal renal function, in whom the risk is relatively low. In patients with impaired renal function, particularly those with collagen vascular disease, captopril should be reserved for hypertensives who have either developed unacceptable side effects on other drugs, or have failed to respond satisfactorily to drug combinations.

Captopril tablets are effective alone and in combination with other antihypertensive agents, especially thiazide-type diuretics. The blood pressure lowering effects of captopril and thiazides are approximately additive.
FIELD: medicine. ^ SUBSTANCE: claimed invention relates to field of cosmetology, namely to cosmetic composition for care and make-up of lips, method of lip make-up of and application of copolymer in said composition. Claimed cosmetic composition contains one copolymer in form of block-copolymer, which contains, first block and second block, one non-volatile oil, one oil with glitter effect. First block is obtained from one acrylate monomer of formula CH2=CH-COOR2, where R2 - represents cycloalkyl group, which has 4-12 carbon atoms, and from one methacrylate monomer of formula CH2=C(CH2)-COOR'2, where R'2 represents cycloalkyl group, which has 4-12 carbon atoms. Second block is obtained from monomer of acrylic acid and from one other monomer with temperature of vitrifying less or equal 20C. Non-volatile oil has hydrocarbon (polymeric) chain, which contains 16 atoms of carbon and has molar weight less than 650 g/mole. Oil with glitter effect has molar weight, more or equal 650 g/mol. ^ EFFECT: composition insures novel cosmetic product and has good properties of comfort, good stability and glitter effect. ^ 26 cl, 2 ex
BACKGROUND: Physical rehabilitation may improve health and wellbeing outcomes for some adults living with long COVID. However, individuals living with pre-existing multiple long-term conditions (MLTCs) and long COVID may have additional rehabilitation challenges. This scoping review aims to identify the available evidence describing physical rehabilitation interventions for adults living with long COVID, to systematically map the reporting of pre-existing MLTCs, and to describe the characteristics of physical rehabilitation interventions used in adults with both pre-existing long-term conditions (LTCs) and long COVID.
METHODS: MEDLINE, CINAHL, Scopus, APA PsycInfo, medRxiv, OpenGrey and MedNar were searched from January 2020 to July 2023. Eligibility criteria included adults with long COVID, rehabilitation interventions including a physical component in any setting and any study design investigating interventions or intervention content except case series/reports.
RESULTS: Of 5326 unique records, 50 articles met the inclusion criteria, of which 25 (50%) made reference to pre-existing LTCs. These articles included four protocols and one consensus statement. Four of the remaining 20 studies (20%) reported the number of pre-existing LTCs, enabling the differentiation of individuals with MLTCs. One study reported outcomes of individuals with MLTCs separately to those without. The interventions described (k=24) typically consisted of combined aerobic and strength exercises (k=17 (71%)) in an outpatient setting (k=13 (54%)).
CONCLUSIONS: There is limited and inconsistent reporting of the presence of MLTCs in studies of physical rehabilitation for adults with long COVID. Clarity and consistency of reporting of MLTCs is required to enable evaluation and adaptation of interventions to improve health and wellbeing for this population.
Patients stop taking TKI medication within 10 days after enrollment. Patients undergo peripheral blood collection to monitor loss of MMR every 4 weeks in year 1, every 6 weeks in year 2, and every 12 weeks in year 3. Patients who lose their molecular remission may restart TKI medication and are monitored every 4 weeks in year 1, every 6 weeks in year 2, and every 12 weeks in year 3.
Care protocol will be applied to the study group (n=40), starting from the first day spent in the intensive care unit.Care protocol consists of patient's position, mobilization, use of spirometer and shoulder exercises. The bed head of the patient will be raised 30°-45° in line with the application steps. In the study, the patient's in-bed and out-of-bed mobilization will be provided by considering the mobilization application steps, and the patient will be asked to stay out of bed for two hours on the 0 th day after surgery. The patient will be asked to stay out of bed for six hours from the first postoperative day until discharge. After the thoracotomy, the conditions that the doctor considers as complications will be recorded.The time of chest tube removal and the day of discharge will be recorded. In the study, the use of spirometry and shoulder exercises will be carried out by taking into account the implementation steps of the care protocol.