anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a composition for treating, alleviating, or preventing skin pigmentation disorders or symptoms, or a skin-lightening composition, comprising an extract of Dendropanax morbifera Lev. leaves and novel active ingredients isolated therefrom, as effective components. The extract of the present invention and the novel active ingredients isolated therefrom exhibit excellent effects in inhibiting melanogenesis and inhibiting the expression of melanogenesis-related proteins (MITF, Tyrosinase, TRP-1, and TRP-2) in melanoma. Accordingly, the extract of the present invention and the novel active ingredients isolated therefrom may be beneficially used as a cosmetic composition for preventing or treating various skin pigmentation disorders including hyperpigmentation. A composition having skin-lightening activity, comprising an extract of Dendropanax morbifera Lev. leaves and novel two types of single components as effective components, may be used as a pharmaceutical composition, a cosmetic composition, or a food composition capable of preventing or treating various skin pigmentation disorders including hyperpigmentation.
The invention relates to a pill for stopping bone hyperplasia. The pill is a medicine for treating hyperosteogeny and joint hypertrophy, concretely is a Chinese patent medicine prepared by taking Chinese herbal medicines as raw materials, and is capable of treating hyperosteogeny, joint hypertrophy and osteoarthritis caused by joint hypertrophy. The invention also relates to a preparation method of the medicine. The pill is an oral small honey pill prepared by taking radix rehmanniae preparata, herba cistanches, deerhorn glue, radix ginseng rubra (removing stem basal part), donkey-hide glue, caulis spatholobi, herba epimedii (processed), rhizoma drynariae (processed) and semen raphani as bulk drugs and performing screening, drying and crushing on the raw materials through a provided pill preparation technology. The provided formula is definite in therapeutic effect, and the pill is an ideal medicine capable of rapidly treating hyperosteogeny, joint hypertrophy and osteoarthritis caused by joint hypertrophy. The pill is simple in preparation method, easy to process and easy for large-scale production.
FIELD: medicine. ^ SUBSTANCE: invention refers to surgery, and can be applied for treating trophic ulcers. It involves fenestration of a wound surface up to healthy, blood-supplied underlying tissue. It is followed with tangential excision of the wound surface. A complete wound hemostasis is carried out. Foetal allofibroblasts are injected in amount 1-7 million cells in a region of the fenestrated openings with irrigating a surface of trophic ulcer with a foetal allofibroblast solution. Autodermoplasty with a split-thickness sieve graft is performed. ^ EFFECT: method allows to stimulate granulation tissue growth in extensive injury. ^ 2 ex, 4 dwg
PURPOSE: Inguinal hernia repair remains one of the most common elective general surgical procedures. Previous studies have suggested high rates of chronic pain afterwards. The aim of this study was to evaluate changes in quality of life after local anaesthetic (LA) inguinal hernia surgery performed in a primary care setting.
METHODS: Quality of life (QoL) was measured in all patients both pre-operatively and at 6-months post-operatively using the European Hernia Society Scoring tool. Data was analysed by tertile grouping according to initial symptom score.
RESULTS: 497 patients filled out pre-operative QoL forms between June 2020 and May 2022. Post-operative QoL scores were received from 179 patients (164 male (91.6%)). Median pre-operative score was 33 (IQR 20-48). Median post-operative score was 4 (IQR 1-11). Mean improvement in QoL score was 27.8. Nine patients had a worse score at 6-months compared to pre-op (5%). When the data was analysed by pre-op QoL group as expected the low symptom group (score 0-10) had minimal improvement in QoL (0.23) and 5 out of 13 patients (38%) had a worse score. The medium group (score 11-40) had a mean improvement in QoL of 17.25 with 3 out of 92 (3.2%) experiencing a worse score. The high symptom group (score 41-90) had a mean improvement in QoL of 45.4 with only 1 of 76 (1.3%) experiencing a worse score.
CONCLUSIONS: LA Inguinal hernia repair improves QoL substantially 6-months after surgery. However, in those patients with low pre-operative scores (< 11) the gain is minimal and rates of chronic symptoms following surgery are very high. We recommend avoiding surgery in this group and instead adopting a surveillance approach.
Participants randomly assigned to this arm will receive 16 weeks of NB medication. NB medication will combine naltrexone sustained-release (SR, 32 mg/day) combined with bupropion SR (360 mg/day) taken daily in pill form.
<P>PROBLEM TO BE SOLVED: To provide a method for separating the larvae of an insect for industrially producing a useful substance in the insect, to provide a method for conveying the larvae, to provide a method for arranging the larvae, and to provide a method for stabbing the larvae.  <P>SOLUTION: That the larvae of Sarcophaga peregrine creep outside a container and drop from the outer wall of the container to pupate is utilized to confirm the separation and maturity of the larvae. The dropped larvae are conveyed with a cold water flow to perform both the washing and cold anaesthesia of the larvae. The water flow route is sequentially thinned to disperse the larvae, and the larvae are sequentially arranged in mesh trays, one by one. At the time, off-spec larvae are removed. When the larvae can not be arranged for a prescribed time, the mesh is conveyed being empty to prevent the congestion of an arrangement process. The arranged larvae are sequentially stabbed to produce an antibacterial peptide. At this time, a stabbing operation is not carried out at prescribed positions where the larvae are not arranged.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Impulse oscillometry (IOS) is a sensitive tool for assessing small airway function in patients with chronic obstructive pulmonary disease (COPD). This study aimed to differentiate between COPD, small airway disease (SAD), and normal groups using IOS, and to evaluate the clinical applicability of IOS. This retrospective cohort study was conducted from January 2020 to February 2022. The eligible population comprised adult patients who simultaneously underwent IOS and pulmonary function tests. The diagnostic value of IOS in differentiating SAD and/or COPD from control was analyzed, and the correlations among IOS parameters, lung function, and radiological assessment results were determined. Among the enrolled 306 patients, 38 (12.4%) had SAD and 134 (43.8%) had COPD. The remainder comprised the control group without COPD and/or SAD. Abnormal airway resistance according to IOS parameters was detected in 17.2% of the patients in the control group, 47.2% of those in the SAD group, and 55.2% of those in the COPD group. Airway resistance estimated by IOS were significantly higher in the SAD and COPD groups than in the control group and correlated with lung function and radiological airway wall thickness. We developed a composite index called the IOS severity index (IOSsi) using IOS parameters that can predict SAD and COPD, and IOSsi showed significantly differentiation of SAD and/or COPD from control. Especially, IOSsi value ≥ 4 was associated with an increased risk of SAD and/or COPD and also with risk for moderate-to-severe exacerbation in patients with COPD. IOS may be a useful tool to differentiate disease status and evaluate disease severity and prognosis in patients with SAD and/or COPD, and a prognostic factor of COPD.
Sexual wellness or sexual fitness is enhanced over time by administrating on a daily basis a source of proanthocyanidins and a source of arginine. Both sources may be blended into a composition or taken separately from a kit. The source of arginine may be a salt or peptide of L-arginine and aspartic acid such as arginine aspartate. The proanthocyanidins stimulate an endothelial NO-synthase enzyme, which serves as a catalyst for synthesis of the nitric oxide from a substrate that is the source of the arginine. A sufficient amount of the nitric oxide is released over time to enhance sexual wellness or sexual fitness. In case of low levels of androgenic hormones in both sexes, the combination may contain as a further ingredient a sex hormone or a sex hormone precursor or a sex hormone stimulant or a sex hormone bioavailability enhancer.
BACKGROUND: WD repeat domain 43 (WDR43) is a protein component that encodes WD-repeats and is involved in ribosome biogenesis. However, little is known about the role of WDR43 in cancer prognosis and immune modulation.
METHODS: In this study, we analyzed the expression and prognostic significance of WDR43 in pan-cancer using the Cancer Genome Atlas, the Genotype-Tissue Expression, and the Human Protein Atlas. We also examined the differential expression of WDR43 in liver hepatocellular carcinoma (LIHC) and adjacent tissues of 48 patients using immunohistochemistry. Additionally, we investigated the correlation between WDR43 and clinical characteristics, gene alterations, tumor mutation burden, microsatellite instability, mismatch repair, tumor microenvironment, immune infiltrating cells, and immune-related genes using bioinformatics methods. Gene set enrichment analysis was conducted, and potential biological mechanisms were identified.
RESULTS: Immunohistochemistry staining showed that WDR43 was overexpressed in LIHC among 48 patients. Upregulation of WDR43 was associated with unfavorable prognosis, including overall survival in various types of cancer such as LIHC, uterine corpus endometrial cancer, head and neck squamous cell carcinoma, and pancreatic adenocarcinoma. Differential expression of WDR43 was significantly correlated with microsatellite instability, mismatch repair, and immune cell infiltration. Gene ontology annotation analysis revealed that these genes were significantly enriched in immune-related functions, including immune response, immune regulation, and signaling pathways.
CONCLUSION: We conducted a thorough investigation of the clinical features, phases of tumor development, immune infiltration, gene mutation, and functional enrichment analysis of WDR43 in various types of cancer. This research offers valuable insight into the significance and function of WDR43 in clinical therapy.
Patients receive olaparib PO BID the day before standard RT commences (Day 0) and throughout the RT course until the last day of RT administration. Olaparib is also continued on weekends (routine days without RT) throughout the RT course. Patients undergo standard radiation therapy 5 days per week for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo blood sample collection throughout the study.
The saphenous vein, which runs from the ankle to the groin along the inside of the leg, is commonly used as a graft for people undergoing a CABG surgery. The vein is removed from the leg and reattached to the heart to create a detour around the blocked part of a coronary artery. Following this procedure, many people are prescribed aspirin as a way to increase the chance that the graft procedure will be successful. However, saphenous vein graft failure may still occur in some people, indicating a need to understand why this happens and who might be at risk for graft failure. Thrombin, a protein involved in the blood clotting process, is somehow related to aspirin resistance, abnormalities in blood flow, and cell disruption within the saphenous vein, all factors thought to increase the risk of graft failure. The purpose of this study is to evaluate the likelihood that a burst in thrombin contributes to graft failure in people who have recently undergone a CABG procedure using the saphenous vein.

This study will enroll individuals undergoing CABG surgery at the University of Maryland. Prior to and immediately following surgery, an incision will be made in the skin and the time required for the blood to form a clot will be determined. During surgery, participants' blood vessels will be examined using imaging and cell analysis techniques. Blood collection will occur before surgery, immediately after surgery, and on Days 1, 3, and 30 following surgery. A portion of blood will be frozen for future analysis. An x-ray of the saphenous vein will be performed on Day 5 and again at a follow-up visit 6 to 12 months following surgery. Kidney function will be measured at both of these visits prior to the x-ray procedure. At the second visit, health and mental status questionnaires will be completed.
PURPOSE:To provide a solid bathing agent having a complex outer appearance and a high tasteful feeling without being cleaved or broken by adding polyethylene glycol to a dry powdery raw material for a bathing agent and subsequently molding the mixture. CONSTITUTION:20-80wt.% of polyethylene glycol having a mol.wt. of 3000-10000 and, if necessary, further a perfume, a dyestuff, a medicine, a vitamin, etc., are added to 20-80wt.% of a dry powdery raw material for a bathing agent and the mixture is melted at 65-100 deg.C. The melted mixture is injected into a mold, allowed to stand for 30-60min at the room temperature for the cooling and solidification thereof and subsequently molded into the objective article. The injection of the melted mixture into the mold is carried out by using a known injection device, etc., or by decanting the mixture by a manual operation. The cooling solidification process may be performed by a water cooling method, an air cooling method, etc.
One of the most challenging aspects of Pediatric Dentistry is the management of child behavior. Anxiety is often manifested by children during dental appointments, and may represent a challenge in the dental surgeon's clinical practice. Among the procedures performed, local anesthesia is one of the factors that influence the increase in fear and anxiety in children in relation to dental procedures. In view of the basic techniques used to manage children's behavior, distraction has been widely used to provide a more relaxed and effective experience during dental treatment for children. Thus, this study aims to evaluate the effect of the use of virtual reality glasses as an audiovisual distraction technique during anesthesia in behavior, anxiety and pain perception, comparing it with traditional behavior management techniques. A sample of 44 children was estimated and will be selected with the following inclusion criteria: be between 5 and 9 years of age; good general health; no prior dental experience involving anesthesia in the last 2 years; need for restorative treatment or exodontia under local anesthesia. Children with physical or mental disabilities will be excluded and those who report poor behavior in dental consultations will be excluded. The sample will be randomized through the draw of envelopes at the time of the service, being 22 envelopes for the group that will use the glasses during the procedure(G0) and 22 envelopes containing group that will not use the glasses in consultation (G1).

The treatments will be performed in 2 visits, the first for initial examination, and the other for performing the procedures are either extraction or restorative treatment with the use of local anesthesia. During dental treatment, the dentist will explain the procedure in layman\'s terms using the basic techniques of behavior management, such as the \"tell-show-do\" technique, positive reinforcement, conventional distraction in all consultations. When using the distraction technique with virtual reality during the procedure, the virtual stereo glasses model HDMI-MHL 98 Inches (98) will be used. In all two consultations, VENHAM anxiety will be assessed through VENHAM scale and heart rate measurement at the beginning, during and at the end of the visit, as well as the perception of pain during the procedure (FLACC) and after finishing the service through the FPS-R scale. During the visits, the data will be collected using a previously tested tab. The data will be entered into a worksheet in the Microsoft® Excel® 2016 program and analyzed in the Stata 14.0 program. There will be a single blind blinding: both for the typist and who will analyze the data. A descriptive analysis of the data will be performed, obtaining the absolute and relative frequencies. Comparisons in the outcomes of interest between groups G0 and G1 will be performed using the chi-square test for dichotomous variables and the t-test for comparison of means. A significance level of 5% will be adopted for all analyzes.
The present invention relates to an automatic liposome preparation equipment and method for preparing liposome by using said equipment. Said equipment includes 1). high-pressure pump; 2). solution mixer; 3). liposome grain size control device; and 4). high-pressure ultrafiltering dialysis column. Said invention uses the high-pressure pump to make the phospholipid dissolved in organic phase, liposoluble medicine and aqueous solution be quickly mixed in solution mixer to obtain multiphase multilayer liposome, then makes said multiphase multilayer liposome directly pass through liposome extruding device so as to obtain large monochamber liposome, and the medicine which is not wrapped in the liposome and organic solvent can be removed by using high-pressure ultrafiltering dialysis column.
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a high degree of comorbidity, including substance misuse. We aimed to assess whether ADHD polygenic risk scores (PRS) could predict ADHD diagnosis in alcohol dependence (AD). ADHD PRS were generated for 1223 AD subjects with ADHD diagnosis information and 1818 healthy controls. ADHD PRS distributions were compared to evaluate the differences between healthy controls and AD cases with and without ADHD. We found increased ADHD PRS means in the AD cohort with ADHD (mean 0.30, standard deviation (SD) 0.92; p = 3.9 × 10-6); and without ADHD (mean - 0.00, SD 1.00; p = 5.2 × 10-5) compared to the healthy control subjects (mean - 0.17, SD 0.99). The ADHD PRS means differed within the AD group with a higher ADHD PRS mean in those with ADHD, odds ratio (OR) 1.34, confidence interval (CI) 1.10 to 1.65; p = 0.002. This study showed a positive relationship between ADHD PRS and risk of ADHD in individuals with co-occurring AD indicating that ADHD PRS may have utility in identifying individuals that are at a higher or lower risk of ADHD. Further larger studies need to be conducted to confirm the reliability of the results before ADHD PRS can be considered as a robust biomarker for diagnosis.
Itraconazole is mainly metabolized through CYP3A4. Other substances that either share this metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of itraconazole. Some concomitant drugs have the potential to interact with itraconazole resulting in either increased or sometimes decreased concentrations of itraconazole. Increased concentrations may increase the risk of adverse reactions associated with itraconazole. Decreased concentrations may reduce itraconazole efficacy.

Table 2 lists examples of drugs that may affect itraconazole concentrations, but is not a comprehensive list. Refer to the approved product labeling to become familiar with the interaction pathways, risk potential and specific actions to be taken with regards to each concomitant drug prior to initiating therapy with itraconazole.

Although many of the clinical drug interactions in Table 2 are based on information with a similar azole antifungal, ketoconazole, these interactions are expected to occur with itraconazole.
PURPOSE: Cytotoxic lesions of corpus callosum (CLOCCs) are associated with many disease entities. Serious neurological complications after coronavirus disease 2019 (COVID-19) vaccination are rare.
CASE REPORT: A 20-year-old man presented with severe headache for 2 days. He had received the first dose of ChAdOx1nCoV-19 COVID-19 vaccine 5 days ago. Persistent dull headache occurred on the third day after vaccination and intensified gradually to awaken him from sleep at night. No neck stiffness was observed. Brain magnetic resonance angiography (MRA) 9 days after vaccination revealed an oval-shaped diffusion-weighted restriction lesion at the splenium of corpus callosum with a mildly high signal intensity on T2-weighted images (T2WI) and low signal intensity on apparent diffusion coefficient (ADC) imaging but without enhancement after contrast injection. A COVID-19 polymerase chain reaction test was negative. A blood test revealed slight leukocytopenia, thrombocytopenia, and hyponatremia. Further autoimmune and hematological studies were normal. A cerebrospinal fluid study revealed normal intracranial pressure. The patient's headache improved gradually. Follow-up brain MRA 5 weeks after vaccination revealed complete disappearance of the diffusion-weighted restriction lesion of the splenium.
CONCLUSION: CLOCCs are rare transient adverse effect of COVID-19 vaccination possibly related to a cytokine storm. The splenic lesion might disappear spontaneously with a good prognosis.
An interferon inducer isolated from the plant tissue, having an elemental analysis of H: 6.54±0.3% C: 41.9±0.3%, N: 2.39±0.3% and P: 0.28±0.03% and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main constituents amino acids, sugars and phosphoric acid. This substance is believed to be a homogeneous polymer of protein and sugars, containing phosphoric acid. This substance has an excellent interferon inducing activity and low toxicity and is significantly active against various viruses. The interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Carthamus of the family Compositae or a variant thereof containing said active substance and recovering the active substance from the extract thereby obtained. Preferably, the active substance may be extracted from the flower of this plant with water and the recovery may be effected by ultrafiltration using a membrane capable of fractionating substances having a molecular weight of from 200,000 to 1,000,000. Pharmaceutical composition of this invention comprises as active ingredient the interferon inducer of this invention in association with a pharmaceutical carrier or excipient.
When the abdominal wound is closed, the operator performs needle insertion at 14 sites near the incision site under the guidance of ultrasonography. When the needle is in the abdominal muscle, the operator performs muscle stimulation for about 10 seconds per needle insertion.
Clofarabine Dose escalation starting 20 mg/m2/d days 1-5 Mitoxantrone 12 mg/m2/d days 3-6. Rituximab in patient with CD20+ disease only 375 mg/m2 day 1, 8, 15. IT Depocyt 35 or 50 mg/dose day 1 per cycle. IT ARA-C in children \< 3 years age based dosing.
A method and system for transcribing dictation information from an author in an electronic communication environment and permitting real-time review and correction of the transcribed information by the author is disclosed. An author may request either a particular or next-available transcriptionist for transcribing a document using a first communication device. If a transcriptionist accepts the request using a second communication device, a communication session is initiated. The author dictates information using the first communication device. The transcriptionist receives the information via the second communication device and transcribes the information. As the information is transcribed, the first communication device displays the transcribed information substantially in real time. The author and/or the transcriptionist may edit the displayed information during the communication session. When transcription of the information is completed, the transcribed information is stored, and the communication session is terminated.