anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with a high propensity for early metastatic spread. Emerging evidence shows that extracellular vesicles (EVs) are key players in cancer metastasis, but their role in NPC metastasis remains poorly understood. We here present the first description of the proteomic and functional profiles of serum-derived circulating small EVs in metastatic NPC patients. To enhance the capture of low-abundance signaling proteins in EVs, timsTOF-based four-dimensional label-free quantitative proteomics was employed. We found that metastatic NPC patients (M-NPC-EVs) exhibited the highest serum EV levels compared to locoregional patients (L-NPC-EVs) and healthy subjects (Normal-EVs). The proteome of M-NPC-EVs differed substantially from L-NPC-EVs and was functionally enriched in pathways regulating cell polarity and motility, glucose metabolism, and angiogenesis. Functional assays testing individual EV samples demonstrated that M-NPC-EVs pronouncedly enhanced NPC cell migration, invasion, and the formation of lamellipodia and filopodia in vitro, and promoted angiogenesis in subcutaneous Matrigel plugs in vivo. In silico analyses suggested that PTPRA, TPI1 and GPI highly enriched in M-NPC-EVs were putative drivers underlying the motogenic and angiogenic activities of M-NPC-EVs, and their high expression levels were associated with a poor prognosis of NPC patients. The increased expression of PTPRA, TPI1 and GPI in M-NPC-EVs was then validated in an independent cohort consisting of 175 NPC patients (locoregional n = 114; metastatic n = 61). Together, utilizing patient-derived EVs, we mimicked the potential pro-metastatic functions of EVs in NPC patients in vitro and in vivo and provided novel insights into their bioactive cargoes.
The present disclosure involves a method of setting stimulation parameters for neurostimulation. A plurality of stimulation parameters available for bracketing is displayed. The stimulation parameters are selected from the group consisting of: stimulation current amplitude, pulse width, frequency, and contact location. Thereafter, in response to an input from a user, at least a subset of the stimulation parameters is selected for bracketing. A respective initial value is then obtained for each of the stimulation parameters in the selected subset. Thereafter, a bracketing process is used to generate a plurality of bracketed values for each of the stimulation parameters in the selected subset. The bracketed values are generated as a function of the initial value. A plurality of stimulation pulses is then delivered to a patient through a neurostimulator that is automatically programmed with a different combination of the bracketed values for the stimulation parameters for each stimulation pulse.
BACKGROUND/AIM: Heterotopic ossification (HO) is a common complication following total hip arthroplasty. Various prophylactic treatments have been proposed, including radiotherapy (RT). This review summarizes the evidence from meta-analyses on the efficacy of RT in preventing hip HO.
MATERIALS AND METHODS: A literature search was conducted on PubMed. The quality of the meta-analyses was assessed using the AMSTAR-2 tool.
RESULTS: Seven meta-analyses were included. One meta-analysis reported a significant reduction in HO occurrence after RT compared to the control group. Comparing RT and non-steroidal anti-inflammatory drugs, one and two meta-analyses showed significantly greater efficacy of RT in preventing severe HO and better outcomes in patients receiving drugs, respectively. Regarding RT settings, the postoperative and preoperative RT were each supported by one meta-analysis. Furthermore, two meta-analyses showed an advantage of multi-fractionated RT over single fraction RT. The overall confidence rate of the meta-analyses was moderate, low, and critically low in one, three, and three meta-analyses, respectively.
CONCLUSION: RT is a confirmed prophylactic intervention for HO. However, the precise optimization of timing, dosage, and fractionation requires elucidation. Future research should focus on the development of predictive models through large-scale data collection and advanced analytics to refine individualized treatment strategies and assess RT comparative effectiveness with drugs.
Social support is the gratification of basic social needs (affection, belonging, esteem or approval, security, identity) through interaction with others. Social support at school allows students to perceive themselves as competent during learning and to enjoy school in general. Little is known about social support at school for students with sensory disabilities. This review aims to synthesize findings from studies examining social support at school for students with hearing and visual impairments. A search of computerized databases was supplemented by a manual search of the bibliographies of the main publications. The synthesis of the literature suggests that all students need adequate support devices in class and properly trained support teachers. However, visually impaired students are more likely to have access to resources compared to those with hearing impairments. Students with visual impairments attending regular schools are more positive about the availability of resources than those with hearing impairments attending special schools. Overall, senior secondary school students indicate higher resource availability than junior secondary school ones. Still, very few studies have investigated social support for students with sensory disabilities. Thus, further research is needed to confirm these results.
Xenogenesis has been recognized as a prospective method for producing channel catfish, Ictalurus punctatus ♀ × blue catfish, I. furcatus ♂ hybrids. The xenogenesis procedure can be achieved by transplanting undifferentiated stem cells derived from a donor fish into a sterile recipient. Xenogenesis for hybrid catfish embryo production has been accomplished using triploid channel catfish as a surrogate. However, having a surrogate species with a shorter maturation period, like white catfish (Ameiurus catus), would result in reduced feed costs, labor costs, and smaller body size requirements, making it a more suitable species for commercial applications where space is limited, and as a model species. Hence, the present study was conducted to assess the effectiveness of triploid white catfish as a surrogate species to transplant blue catfish stem cells (BSCs) and channel catfish stem cells (CSCs). Triploid white catfish fry were injected with either BSCs or CSCs labeled with PKH 26 fluorescence dye from 0 to 12 days post hatch (DPH). No significant differences in weight and length of fry were detected among BSCs and CSCs injection times (0 to 12 DPH) when fry were sampled at 45 and 90 DPH (P > 0.05). The highest survival was reported when fry were injected between 4.0 to 5.5 DPH (≥ 81.2%). At 45 and 90 DPH, cell and cluster area increased for recipients injected from 0 to 5.2 DPH, and the highest cluster area values were reported between 4.0 to 5.2 DPH. Thereafter, fluorescent cell and cluster area in the host declined with no further decrease after 10 DPH. At 45 DPH, the highest percentage of xenogens were detected when fry were injected with BSCs between 4.0 to 5.0 and CSCs between 3.0 to 5.0 DPH. At 90 DPH, the highest number of xenogens were detected from 4.0 to 6.0 DPH when injected with either BSCs or CSCs. The current study demonstrated the suitability of white catfish as a surrogate species when BSCs and CSCs were transplanted into triploid white catfish between 4.0 to 6.0 DPH (27.4 ± 0.4°C). Overall, these findings allow enhanced efficiency of commercializing xenogenic catfish carrying gametes of either blue catfish or channel catfish.
The invention relates to an artificial tooth cleaning agent composition. The composition is prepared through using 40-45 parts by weight of anhydrous sodium carbonate, 15-20 parts by weight of a sodium hydroxide solution, 15-20 parts by weight of sodium perborate, 15-20 parts by weight of sodium persulfate, 0.001-0.002 parts by weight of an acidic red dye, and 0.002-0.004 parts by weight of brilliant blue. The composition is prepared through taking the above raw materials according to the above weight proportions and uniformly mixing. The composition is dissolved in water having a volume 40times higher than the composition when the composition is used. The artificial tooth cleaning agent composition has the advantages of use convenience, substantial decontamination and sterilization effects, and non-toxicity to human bodies. Dirt on artificial teeth is completely removed when the composition solution becomes red from blue, and finally becomes colorless, so it helps people to grasp the cleaning time.
This protocol uses TMR during REM sleep to strengthen associative memories generated by emotional attention bias modification (EABM), an effective treatment for controlling craving levels in patients with Alcohol Use Disorder (AUD). EABM involves exposure to negative emotional words (e.g., frustrated, inferior) associated with alcohol-related cues and positive emotional words (e.g., successful, confident) associated with healthy lifestyle cues. The goal is to reduce alcohol-related cue positive emotional attention bias (EABs). In EABM training, alcohol-related cues and healthy activity (e.g., exercising, reading, playing musical instruments) images are always paired with negative words and positive words, respectively. The TMR group receives the EABM protocol with auditory cue feedback (sound S1-Alcohol; sound S2-Healthy Life); the control group receives the EABM protocol without auditory cue feedback. All patients will perform EABM every evening and will be exposed to sounds S1 and S2 during REM sleep with a wireless headband, which automatically detects sleep stages. Clinical evaluation of the EAB and craving levels of AUD will be conducted before and after (with a 2-week follow-up). The investigators hypothesize that patients treated with EABM and who are exposed during REM sleep to a sound that had previously been associated with the new negative memory of alcohol and the positive memory of a healthy lifestyle (TMR group) will have more reduced EAB and craving levels compared to participants exposed to the same, but non-associated, sound during REM sleep (control group).
Gastric mucin, suitable for preparations for internal use, is obtained by extracting stomach linings, preferably of hogs, with aqueous acid, e.g. hydrochloric acid, filtering, adjusting the acidity to the isoelectric point of the mucin and precipitating the mucin by the addition of a water soluble organic liquid such as alcohol or acetone.  The precipitate is treated with a compound such as sodium carbonate or bicarbonate in aqueous suspension to form a mucin salt which is separated by decanting and draining and is then dried.  The potassium and lithium compounds may also be prepared in a similar manner.  The substances are stated to be efficacious in the treatment of acidity of the stomach.ALSO:Gastric mucin, suitable for preparations for internal use, is obtained by extracting stomach linings, preferably of hogs, with aqueous acid, e.g. hydrochloric acid, filtering, adjusting the acidity to the isoelectric point of the mucin and precipitating the mucin by the addition of a water soluble organic liquid such as alcohol or acetone.  The precipitate is treated with a compound such as sodium carbonate or bicarbonate in aqueous suspension to form a mucin salt which is separated by decanting and draining and is then dried.  The potassium and lithium compounds may also be prepared in a similar manner.  The substances are stated to be efficacious in the treatment of acidity of the stomach.
PCT No. PCT/JP91/01277 Sec. 371 Date Mar. 13, 1992 Sec. 102(e) Date Mar. 13, 1992 PCT Filed Sep. 25, 1991 PCT Pub. No. WO92/04906 PCT Pub. Date Apr. 2, 1992.A method for removing leukocytes from a leukocyte-containing blood product, include subjecting a leukocyte-containing blood product to a first stage leukocyte-removing treatment to remove at least 60% of all leukocytes contained in the leukocyte-containing blood product, thereby obtaining a leukocyte-depleted blood product, and passing the leukocyte-depleted blood product through a microfilter element to perform a second stage leukocyte-removing treatment, the microfilter element having a non-woven or a woven fabric including fibers having an average diameter of from 0.3 to 1.6 (my)m. A filter system for removing leukocytes from a leukocyte-containing blood product, to includes a first filter element for the first stage and a second filter element for the second stage, wherein the first filter element communicates with the second filter element and is positioned upstream of the second filter element with respect to a direction in which a leukocyte-containing blood product is to be flowed. By the method and filter system of the present invention, leukocytes can effectively be removed from a leukocyte-containing blood product to a level of a leukocyte residual ratio of 10-4 or less and, in addition, a miniaturization of leukocyte-removing filters can be attained.
Hoosier Sport is a comprehensive sport-based youth development program designed to enhance the health and wellness of rural children and adolescents. The program leverages the power of sport to teach essential sport skills, leadership qualities, and promote health education. Conducted primarily in physical education (PE) classes, with occasional sessions in health classes, Hoosier Sport spans eight weeks with sessions twice a week. The curriculum focuses on unique sports such as strength training, pickleball, and flag football, and integrates activities that foster leadership (e.g., goal setting) and health education (e.g., the importance of regular exercise and a healthy lifestyle).

A key objective of Hoosier Sport is to explore how participation in sports can satisfy the basic psychological needs of autonomy, competence, and relatedness. By providing structured yet flexible activities that allow for individual achievement and peer interaction, the program aims to enhance students' intrinsic motivation to engage in physical activity. Additionally, Hoosier Sport addresses the growing concern of screen time and social media usage, which are known to negatively impact physical activity levels. The program integrates discussions and activities that encourage students to reflect on their screen time habits, understand the effects of social media on body image and activity levels, and develop healthier behaviors.

To objectively measure the impact of the program on physical activity (PA), Hoosier Sport utilizes advanced accelerometers (AX3 devices). These devices are worn by students for a week at a time, capturing detailed data on their physical activity patterns. This data allows the research team to accurately assess changes in PA levels throughout the program, providing insights into the effectiveness of the intervention. Alongside physical activity, the program collects data on psychosocial factors, such as self-esteem and social skills, to identify broader health and behavioral outcomes. Exploratory data includes screen time, social media usage, as well as inhibitory control. All collected data is handled anonymously, following strict Institutional Review Board (IRB) protocols to ensure the privacy and protection of participants. Through this multifaceted approach, Hoosier Sport aims not only to improve physical health but also to foster psychological well-being and sustainable healthy behaviors among rural youth.
Patients undergoing hemodialysis experience anxiety and pain related to the insertion of hemodialysis needles, estimated 320 times in total per year. The pain experienced is mostly caused by needle insertion into a fistula. Pain control is one of the main nursing tasks. Pain relief leads to the acceptance of the procedure and ultimately enhances the patients' quality of life. The use of virtual reality to reduce pain and anxiety during the arteriovenous fistula cannulation procedure is based on the concept that the perception of pain can be controlled because an individual is able to process only a limited amount of information at once. As such, the use of virtual reality during painful procedures may serve as a distraction.
Background: Sepsis-associated brain injury is associated with deterioration of mental status, persistent cognitive impairment, and morbidity. The SUR1/TRPM4 channel is a nonselective cation channel that is transcriptionally upregulated in the central nervous system with injury, allowing sodium influx, depolarization, cellular swelling, and secondary injury. We hypothesized that genetic variation in ABCC8 (SUR1 gene) and TRPM4 would associate with central nervous system dysfunction in severe pediatric sepsis. Methods: 326 children with severe sepsis underwent whole exome sequencing in an observational cohort. We compared children with and without central nervous system dysfunction (Glasgow Coma Scale <12) to assess for associations with clinical characteristics and pooled rare variants in ABCC8 and TRPM4. Sites of variation were mapped onto protein structure and assessed for phenotypic impact. Results: Pooled rare variants in either ABCC8 or TRPM4 associated with decreased odds of central nervous system dysfunction in severe pediatric sepsis (OR 0.14, 95% CI 0.003-0.87), P = 0.025). This association persisted following adjustment for race, organ failure, viral infection, and continuous renal replacement therapy (aOR 0.11, 95% CI 0.01-0.59, P = 0.038). Structural mapping showed that rare variants concentrated in the nucleotide-binding domains of ABCC8 and N-terminal melastatin homology region of TRPM4 . Conclusion : This study suggests a role for the ABCC8/TRPM4 channel in central nervous system dysfunction in severe pediatric sepsis. Although exploratory, the lack of therapies to prevent or mitigate central nervous system dysfunction in pediatric sepsis warrants further studies to clarify the mechanism and confirm the potential protective effect of these rare ABCC8/TRPM4 variants.
Communication devices and systems and methods of analyzing, authenticating, and transmitting medical information are provided herein. A communication device includes a housing, a transceiver circuit, a processor, and a battery circuit. The transceiver circuit has a communication channel. The processor is in communication with the transceiver circuit. The communication channel receives medical data from at least one medical instrument. The transceiver circuit transmits the medical data to a network or server. Disclosed systems and methods collect, analyze and build a proxy of patient health and response to treatment, securely authenticate, encrypt, and transmit data medical instruments to nurses and the EMR for use by medical professionals.
The invention provides a pharmaceutical composition for treating gouty arthritis and belongs to the technical field of traditional Chinese medicine compositions. The pharmaceutical composition comprises, by weight, 10-50 parts of herba sarcandrae, 10-30 parts of fallopia multiflora (Thunb.) Harald., 15-40 parts of polygonum cuspidatum Sieb.et Zucc., 8-25 parts of schisandra chinensis (Turcz.) Baill., 10-40 parts of rhamnus aurea, 5-25 parts of red peony root, 10-35 parts of ganoderma lucidum Karst. and 10-30 parts of costusroot. Different drug forms can be prepared from the pharmaceutical composition and adjuvant materials acceptable medically. The pharmaceutical composition for treating the gouty arthritis has the advantages that test results show that the pharmaceutical composition is better in efficacy as compared with traditional Chinese medicine or western medicine for treating the gouty arthritis and is higher in safety; the pharmaceutical composition is low in cost and simple in preparation method and has remarkable practical and economic value.
A compound of formula (I), wherein; R is alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group, optionally substituted by one or more hydroxyl groups; cycloalkyl; optionally substituted cycloalkanyl; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be saturated, or fully or partially unsaturated and which may optionally be substituted by one or more alkyl groups or halo atoms; or R is optionally substituted phenyl or a compound of formula (a), wherein; X is O, S or -CH2 -; a, b, e, and d are each independently selected from an integer 0 to 2 and a+b+c+d < 5; or R is R24 , wherein  R24 is H, optionally substituted alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl; or optionally substituted cycloalkyl or cycloalkenyl; or an optionally substituted 3 to 6 membered oxygen or sulphur containing a heterocyclic ring; or a group of formula SR23, wherein R23 is alkyl, alkenyl, alkylnyl, cycloalkyl, cycloalkenyl, or optionally substituted phenyl. R4 is H or an acyl of an organic acid of up to 18 carbons. The compounds of this invention are useful as antibacterial agents and antiprotozoa agents and for other applications (e.g. anticancer, atherosclerosis, gastric motility reduction, etc.) in mammals, including man, as well as in fish and birds. The invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial protozoa infections by administering such compounds. The invention also relates to methods of preparing such compounds and to intermediates useful in such preparation.
Spermatozoa are immobilised by cooling and introduced into a nutritive fractionating media. The fractionating media has a density gradient so that when the sperms are introduced into the middle of the column the denser X-chromosome contg. sperms descend and the less dense Y-chromosome contg. sperms rise. The fractionation is carried out under reduced pressure at -5 degrees to +2 degrees C and a pH of 6-8 in a media having a S.G. of 1.01-1.15 g./cm3 at 0 degree C. The appts. for the fractionation is claimed. The process allows one to choose the sex of the progeny of mammals for economic and social reasons.
After being informed about the study and potential risks, written consent was obtained from all patients. In order to effectively manage postoperative analgesia in patients planned for lower abdominal surgery (inguinal hernia and undescended testicles), patients will begin to be observed after routine anesthesia and block techniques applied to the patients. After these procedures, the block is applied to the patient using the appropriate method, under aseptic conditions and under ultrasound guidance. Intraoperative hemodynamic changes of the patients, intraoperative opioid consumption and bispectral index monitoring values of the patients will be kept throughout the peroperative period. Postoperative follow-ups will be made at 0nd, 1st, 2nd, 4th, 6th, 12th, and 24th hours to evaluate the initial analgesic consumption, need for analgesics types, pain levels, and parental satisfaction. In this way, it is aimed to compare the Transversalis Fascia Plan Block and Transversus Abdominis Plan Block as an effective analgesic application in lower abdominal surgery in children and to show the analgesic method that can be used effectively in postoperative pain management.