anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The main objective of this study was to assess the IPP complication rates of patients undergoing placement via perineal incision versus more traditional penoscrotal approach in synchronous dual implantation. We identified 38 patients who underwent dual implantations of an IPP and AUS or urethral sling from 2011 to 2021 at a single tertiary center, 24 via perineal and 14 via penoscrotal incision. All IPP implants were done by a single surgeon. IPP postoperative complications were captured using the Clavien-Dindo classification at three separate time points, < 30 days, 30 days - 6 months, and > 6 months. The perineal group had two complications, IPP explantation due to rectourethral fistula (Grade III, > 6 months), and IPP explantation due to chronic genital pain (Grade III, > 6 months). The penoscrotal group had three complications, post-operative urinary retention requiring catheterization (Grade I, < 30 days), incision site infection (Grade I, < 30 days), and IPP explantation due to infection (Grade III, 30 days to < 6 months). There was no statistically significant difference in rate of patients with IPP complications between the two groups (p = 0.546) or in rate of IPP device malfunction (p = 0.264). These preliminary findings suggest that the single perineal incision is a viable surgical approach in synchronous dual implantation.
The invention belongs to the technical field of medicine, and particularly relates to a pharmaceutical composition for treating blood vessel stasis type latent glomerulonephritis. The pharmaceutical composition is prepared from, by weight, 4-8 parts of herb of phlegmariurus hamiltonii(Spreng.)Love et Love var.petiolatus(Clarke)Ching, 4-8 parts of multiflora roses, 4-8 parts of herb of CerastiumrvenseL., 4-8 parts of rhizomes of largeleaf curculigo, 4-8 parts of roots of Pecteilis susannae (L.)Rafin., 4-8 parts of sporocarp of pleurotus ostreatus (Jacq. ex Fr.)Quel., 4-8 parts of rhizoma podophylli emodi, 4-8 parts of polyandrous balanophora herb, 4-8 parts of Japanese angelica tree root bark, 4-8 parts of herb of goodyera schlechtendaliana Reichb. f., 4-8 parts of common dysosmatis rhizomes and roots, 4-8 parts of roots of undulateleaf aralia, 4-8 parts of cortex moutan, 4-8 parts of rhizoma alismatis and 4-8 parts of licorice roots. According to the pharmaceutical composition for treating the blood vessel stasis type latent glomerulonephritis, all the medicinal materials are cooperatively used to jointly achieve the effects of nourishing yin and strengthening yang and promoting blood circulation to remove meridian obstruction, the clinical symptoms of a latent glomerulonephritis patient can be effectively improved, the urine erythrocyte quantity is decreased, the 24-hour urine protein quantitative level is lowered, and the glomerular filtration rate is improved.
Unscheduled Bleeding and Spotting

Unscheduled (breakthrough or intracyclic) bleeding and spotting sometimes occur in patients on COCs, especially during the first three months of use. If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy. If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different contraceptive product.

In the clinical trial of Tri-Lo-Marzia, the frequency and duration of unscheduled bleeding and/or spotting was assessed in 1,673 women (11,015 evaluable cycles). A total of 3 (0.2%) women discontinued Tri-Lo-Marzia, at least in part, due to bleeding or spotting. Based on data from the clinical trials, 7 to 17% of women using Tri-Lo-Marzia experienced unscheduled bleeding per cycle in the first year. The percent of women who experienced unscheduled bleeding tended to decrease over time.

Amenorrhea and Oligomenorrhea

Women who use Tri-Lo-Marzia may experience amenorrhea. Some women may experience amenorrhea or oligomenorrhea after discontinuation of COCs, especially when such a condition was pre-existent.

If scheduled (withdrawal) bleeding does not occur, consider the possibility of pregnancy. If the patient has not adhered to the prescribed dosing schedule (missed one or more active tablets or started taking them on a day later than she should have), consider the possibility of pregnancy at the time of the first missed period and take appropriate diagnostic measures. If the patient has adhered to the prescribed regimen and misses two consecutive periods, rule out pregnancy.
Simvastatin will be administered on an outpatient basis orally at a dose of 40 mg once daily. Treatment will start 7 days prior to the planned doxorubicin/cyclophosphamide chemotherapy initiation and will continue for a total of 25 weeks.
The present invention discloses the composition of mifepristone semi-solid skeleton preparation. The present invention comprises the components and the content of 0.5 to 5 wt% of mifepristone, 1 to 50 wt% of surface active agents of which the HLB is more than 12, and 45 to 98.5 wt% of semi-solid skeleton carriers. The present invention has good dissolution performance and high early-pregnancy resistance. The rat Ed50 of the present invention is 17 times more than market troches. The bioavailability of dogs is 5 times more than market troches. The present invention adopts multi-centric random double-blind clinical research (240 pairs). One third dosage of the present invention 50 mg achieves the same clinical effect as market troches 150 mg. The mifepristone capsules of the present invention have the advantages of low dosage, little adverse reaction and high bioavailability.
FIELD: microbiology. SUBSTANCE: nutrient medium for culturing the strain Streptococcus faecium STF-1/56 is prepared on deproteinized curd whey at the following ratio of components, g/1000 ml: glucose, 10; potassium dihydrogen phosphate, 2; ammonium chloride, 5, and in ml: curd whey, 200; Caspian sea water, 80; and tap water, the balance. Caspian sea water is used as an additional source of macro- and trace elements that are necessary for the growth of lactic acid streptococcus Streptococcus faecium STF-1/56. Other components provide the requirement of the strain for macroelements, nitrogen and carbon nutrition. Medium is used for preparing probiotic used for prophylaxis of poultry infection with salmonellae. EFFECT: enhanced prophylaxis, decreased cost.
BACKGROUND Pheochromocytomas, rare tumors arising from the adrenal medulla, can present with highly variable symptoms; therefore, pheochromocytomas frequently remain undiagnosed, leaving the potential for physiological complications. Acutely, these complications include pheochromocytoma crisis, in which high levels of catecholamines are released and cause a life-threatening hypertensive emergency. Over time, undiagnosed pheochromocytomas can lead to cardiovascular damage and end-organ disease related to chronic exposure to elevated blood pressure. CASE REPORT We share a case of pheochromocytoma in a 45-year-old woman who presented with gastrointestinal symptoms of intractable nausea, vomiting, and abdominal pain. Imaging revealed an adrenal mass that had radiographic features that were most consistent with myelolipoma. Before exposing the patient to anesthesia and endoscopy for further diagnostic workup of her gastrointestinal symptoms, which can trigger a catecholamine surge in individuals with a pheochromocytoma, further biochemical testing was performed. Testing of plasma and urine confirmed pheochromocytoma, and surgical resection was performed for definitive treatment. Ultimately, the patient had resolution of her symptoms following the removal of the tumor. CONCLUSIONS The resolution of symptoms following surgical resection suggests that symptoms may have been related to the mass effect of the tumor or as an atypical manifestation of increased catecholamine levels. Additionally, by screening for pheochromocytoma, the patient was able to avoid potential complications that can result from common gastroenterological diagnostic procedures. This case report highlights the potential benefit for screening for pheochromocytoma when faced with symptoms that may be non-specific or related to mass effect upon surrounding organs.
It was a clinical trial with four arms. The research was carried out at the Pharmacology Department, IIMC Riphah University, Rawalpindi. The sample size was calculated to be 380 using the prevalence of disease, z-score, and 5% margin of error. Written informed consent was obtained from the participants. The patients being treated for chronic periodontitis were randomly divided into four groups (I, II, III, and IV). Patients in Group I were subjected to Scaling and root planning alone. Group II patients were given metronidazole gel following Scaling and root planning. Minocycline gel was locally applied subsequent to scaling and root planning in Group III patients. The combination of metronidazole gel and minocycline gel was administered after Scaling and root planning in Group IV patients. Scaling and root planning of all the patients was done. Periodontal probing depth, the color of the gingiva, texture of the gingiva, bleeding on probing, clinical attachment level, and recession were recorded for each patient at baseline visit, after 7 days, and after 15 days to determine and compare the efficacy of local administration of drugs.
An aqueous preparation suitable for use in dyeing live hair comprises a synthetic organic hair dye, a monohydric aliphatic alcohol containing at least 8 carbon atoms in the molecule or a monoester of a dihydric or polyhydric aliphatic alcohol with a fatty acid containing at least 12 carbon atoms in the molecule and an emulsifying agent consisting of either (a) an alkali salt of a sulphonated aliphatic alcohol with at least 8 carbon atoms in the molecule or (b) an alkali salt of an aliphatic sulphonic acid with at least 8 carbon atoms and with or without nitrogen in the molecule. Cholesterin may advantageously be incorporated. Specified dyeing compounds are aromatic diamines, e.g. nitro - p - phenylenediamine and m- and p-toluylenediamines, aminophenols, e.g. nitroaminophenols, p-nitrophenylglycine, 4 : 41-diaminodiphenylamine and 1 : 5 - dihydroxynaphthalene. The alcohol or ester is melted, the emulsifying agent is uniformly admixed, water is added to form a paste and, when this has thickened on cooling, the dyeing compound is uniformly admixed. For use a small quantity of hydrogen peroxide is added.  In examples, preparations are obtained containing (1) stearic acid monoglycol ester, the sodium salt of lauryl alcohol sulphuric acid ester, p-toluylenediamine sulphate, ammonia and water (dyeing blonde); (2) stearic acid monoglycol ester, sodium oleylmethylaminoethanesulphonate, p-nitrophenylglycine, ammonia and water (dyeing yellow blonde); (3) myristyl alcohol, the sodium salt of lauryl alcohol sulphuric acid ester, m- and p-toluylenediamines and water (dyeing blue to blue-green); (4) myristyl alcohol, sodium oleylmethylaminoethanesulphonate, sodium 4-nitro-2-aminophenolate and water (dyeing red); (5) palmityl alcohol, sodium oleylmethylaminoethanesulphonate, 4 : 41-diaminodiphenylamine, 1 : 5-dihydroxynaphthalene, benzyl alcohol, ethyl alcohol and an aqueous soap solution (dyeing blue-green).
BACKGROUND: Antepartum hemorrhage (APH) is an obstetric emergency that complicates pregnancy worldwide and continues to lead to hemorrhagic conditions in parts of Tanzania. Midwifery education received by midwives consists theoretical knowledge on the subject but with no or minimal practical skills in the laboratory, which may reduce their practical capacity as graduated midwives. This study therefore aimed to explore midwives' clinical actions and experiences regarding the care of women with APH in Mwanza region.
METHOD: Qualitative, inductive approach with critical incident technique was used. Data were analysed using the critical incident technique, and a question guide consisting of eleven open-ended questions was used to collect data from 44 out of 60 midwives who graduated not less than one year. A total of 522 critical incidents, with 199 actions and 323 experiences, were identified and categorized into five main areas. Ethical approval was obtained.
RESULTS: Midwives' clinical actions and experiences in caring for women with APH are affected by the knowledge and skills obtained during training at school. They have insufficient theoretical knowledge and practical skills, leading to inadequate identification of the problem and the implementation of care. A need for additional preventive care is described and structural issues, such as co-operation, referral to other instances, access to equipment and relevant treatments need to be improved.
CONCLUSION: The actions taken to provide care for women with APH were related to their ability to identify problems, implement care and carry out structural initiatives. However, the midwives' experience was influenced by an attempt to understand the seriousness of the situation and the existence of an organizational challenge. The results can provide knowledge and tools to improve midwives' education and clinical practice and in the long run, prevent complications, improves health and minimize suffering in women with APH.
OBJECTIVES: I. Determine the toxic effect profile and maximum tolerated dose of interleukin-12 (rhIL-12) in women with advanced breast cancer who have undergone high dose chemotherapy with stem cell rescue. II. Determine the effect of rhIL-12 on cellular and humoral immune systems following high dose chemotherapy. III. Explore the effect on treatment failure of rhIL-12 after high dose chemotherapy with stem cell rescue.

OUTLINE: This is a dose escalation study of interleukin-12 (rhIL-12). RhIL-12 therapy begins 3-5 weeks after discharge from the chemotherapy/stem cell transplant hospitalization or 2-3 weeks after completion of posttransplant radiation. Patients receive rhIL-12 subcutaneously twice a week for 12 consecutive weeks. Treatment continues in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients are treated at each dose level of rhIL-12. The maximum tolerated dose is defined as the dose at which no more than 1 of 6 patients experiences dose limiting toxicity. Patients are followed every 2 months after treatment.

PROJECTED ACCRUAL: Approximately 6-35 patients will be accrued for this study within 1-2 years.
Sectral is well absorbed from the GI tract. It is subject to extensive first-pass hepatic biotransformation, with an absolute bioavailability of approximately 40% for the parent compound. The major metabolite, an N-acetyl derivative (diacetolol), is pharmacologically active. This metabolite is equipotent to Sectral and in cats is more cardioselective than Sectral; therefore, this first-pass phenomenon does not attenuate the therapeutic effect of Sectral. Food intake does not have a significant effect on the area under the plasma concentration-time curve (AUC) of Sectral although the rate of absorption and peak concentration decreased slightly. 

The plasma elimination half-life of Sectral is approximately 3 to 4 hours, while that of its metabolite, diacetolol, is 8 to 13 hours. The time to reach peak concentration for Sectral is 2.5 hours and for diacetolol, after oral administration of Sectral, 3.5 hours. 

Within the single oral dose range of 200 to 400 mg, the kinetics are dose proportional. However, this linearity is not seen at higher doses, probably due to saturation of hepatic biotransformation sites. In addition, after multiple dosing the lack of linearity is also seen by AUC increases of approximately 100% as compared to single oral dosing. Elimination via renal excretion is approximately 30% to 40% and by nonrenal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall. 

Sectral has a low binding affinity for plasma proteins (about 26%). Sectral and its metabolite, diacetolol, are relatively hydrophilic and, therefore, only minimal quantities have been detected in the cerebrospinal fluid (CSF). 

Drug interaction studies with tolbutamide and warfarin indicated no influence on the therapeutic effects of these compounds. Digoxin and hydrochlorothiazide plasma levels were not affected by concomitant Sectral administration. The kinetics of Sectral were not significantly altered by concomitant administration of hydrochlorothiazide, hydralazine, sulfinpyrazone, or oral contraceptives. 

In patients with renal impairment, there is no effect on the elimination half-life of Sectral, but there is decreased elimination of the metabolite, diacetolol, resulting in a two- to three-fold increase in its half-life. For this reason, the drug should be administered with caution in patients with renal insufficiency (see PRECAUTIONS). Sectral and its major metabolite are dialyzable. 

Sectral crosses the placental barrier and is secreted in breast milk. 

In geriatric patients, the bioavailability of Sectral and its metabolite is increased, approximately two-fold, probably due to decreases in the first-pass metabolism and renal function in the elderly.
Rheumatoid arthritis (RA) is a highly prevalent and chronic inflammatory synovial joint disease manifested by hyperplasia and continuous inflammation. Curcumin (Cur) has been studied for alleviating RA. However, poor stability and oral bioavailability restrict its therapeutic value. Bisdemethoxycurcumin (BDMC), a curcumin (Cur) derivative, exerts better stability and oral bioavailability than Cur. However, the efficacy of BDMC on RA has not been fully clarified. The aim of the study was to investigate the therapeutic effects and underlying mechanisms of BDMC on RA. The in-vivo anti-arthritic activity of BDMC was determined via adjuvant-induced arthritis (AIA) rat model. Paw swelling, body weight, arthritic index, and histopathological assessments were performed. RAW264.7 cell was stimulated by lipopolysaccharides (LPS) in vitro. The cell viability were determined by CCK8 assay, while the migration ability was determined using cell wound healing and transwell assays. Furthermore, in-vivo and in-vitro levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) were assayed by ELISA, and that of IκBα, p-NF-κB, NF-κB, and COX-2 were assessed via Western blot or immunofluorescence. In AIA rat model, it suggested a higher anti-arthritic activity of BDMC than Cur, including amelioration of swelling in hind paws, reduced arthritic index, and alleviated histopathological injury in rats. Furthermore, BDMC also substantially decreased the levels of the aforementioned pro-inflammatory cytokines in both in-vivo and in-vitro, inhibited the IκBα degradation, down-regulated the COX-2 levels and p-NF-κB/NF-κB ratio in AIA rats and LPS-stimulated RAW264.7 cells. Additionally, BDMC showed an inhibitory effect on the migration of LPS-stimulated RAW264.7 cells. BDMC could effectively ameliorate RA by suppressing inflammatory reactions and inhibiting macrophage migration, more potentially than Cur.
This is a prospective cohort study recruiting consecutive men with elevated blood test PSA 4-10 ng/mL, normal prostate on digital rectal examination, and result for blood Prostate Health Index (phi) known. A multi-parametric MRI prostate with contrast will be performed in all subjects. MRI prostate will be reported according to PI-RADS (Prostate Imaging-Reporting and Data Systems) v2.1 recommendations\[10\] and scored from 1 to 5. A PI-RADS score of 3-5 is considered abnormal. The proportion of abnormal MRI in different phi ranges (primary outcome) will be compared.

The subjects will be offered a prostate biopsy according to usual clinical indications in our hospital: In men with phi \>35 (higher risk of significant prostate cancer), prostate biopsy (systematic biopsy, plus MRI-guided if abnormal MRI) will be offered. In men with phi \< 35 (lower risk of prostate cancer), prostate biopsy (systematic plus MRI-guided) will be offered only if MRI is abnormal.
BACKGROUND: Recent improvements in sequencing technologies enabled detailed profiling of genomic features. These technologies mostly rely on short reads which are merged and compared to reference genome for variant identification. These operations should be done with computers due to the size and complexity of the data. The need for analysis software resulted in many programs for mapping, variant calling and annotation steps. Currently, most programs are either expensive enterprise software with proprietary code which makes access and verification very difficult or open-access programs that are mostly based on command-line operations without user interfaces and extensive documentation. Moreover, a high level of disagreement is observed among popular mapping and variant calling algorithms in multiple studies, which makes relying on a single algorithm unreliable. User-friendly open-source software tools that offer comparative analysis are an important need considering the growth of sequencing technologies.
RESULTS: Here, we propose Comparative Sequencing Analysis Platform (COSAP), an open-source platform that provides popular sequencing algorithms for SNV, indel, structural variant calling, copy number variation, microsatellite instability and fusion analysis and their annotations. COSAP is packed with a fully functional user-friendly web interface and a backend server which allows full independent deployment for both individual and institutional scales. COSAP is developed as a workflow management system and designed to enhance cooperation among scientists with different backgrounds. It is publicly available at https://cosap.bio and https://github.com/MBaysanLab/cosap/ . The source code of the frontend and backend services can be found at https://github.com/MBaysanLab/cosap-webapi/ and https://github.com/MBaysanLab/cosap_frontend/ respectively. All services are packed as Docker containers as well. Pipelines that combine algorithms can be customized and new algorithms can be added with minimal coding through modular structure.
CONCLUSIONS: COSAP simplifies and speeds up the process of DNA sequencing analyses providing commonly used algorithms for SNV, indel, structural variant calling, copy number variation, microsatellite instability and fusion analysis as well as their annotations. COSAP is packed with a fully functional user-friendly web interface and a backend server which allows full independent deployment for both individual and institutional scales. Standardized implementations of popular algorithms in a modular platform make comparisons much easier to assess the impact of alternative pipelines which is crucial in establishing reproducibility of sequencing analyses.
PURPOSE:To decrease the heterologous interference of heteroantibodies, and to purify the antibody to the one suitable especially for the low-concentration immunoglobulin assay, by immobilizing an antibody of an antibody fluid col lected from two kinds of animals to an insoluble carrier, and contacting the immobilized antibody with the other antibody liquid. CONSTITUTION:In an immunoassay using a sandwich process wherein the antigen separated from the first animal species is sandwiched stepwise with antibodies collected from the second and the third animal species, the antibody is purified by immobilizing either the second or the third antibody to an insoluble carrier (e.g. CNBR-activated sephalose column), and contacting the antibody to the other antibody. The reactive components in the heteroantibodies can be removed, and the mutual interference can be decreased. Accordingly, an immunoassay can be carried out in high sensitivity. It is especially useful for the purification of an antibody suitable for the assay of a low-concentration immunoglobulin.