anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Albumin has a variety of biological functions, such as immunomodulatory and antioxidant activity, which depends largely on its thiol activity. However, in clinical trials, the treatment of albumin by injection of commercial human serum albumin (HSA) did not achieve the desired results. Here, we constructed reduced modified albumin (SH-Alb) for in vivo and in vitro experiments to investigate the reasons why HSA did not achieve the expected effects. SH-Alb was found to delay the progression of liver fibrosis in mice by alleviating liver inflammation and oxidative stress. Although R-Alb also has some of the above roles, the effect of SH-Alb is more remarkable. Mechanism studies have shown that SH-Alb reduces the release of pro-inflammatory and pro-fibrotic cytokine through the mitogen-activated protein kinase (MAPK) signaling pathway. In addition, SH-Alb deacetylates SOD2, a key enzyme of mitochondrial reactive oxygen species (ROS) production, by promoting the expression of SIRT3, thereby reducing the accumulation of ROS. Finally, macrophages altered by R-Alb or SH-Alb can inhibit the activation of hepatic stellate cells and endothelial cells, further delaying the progression of liver fibrosis. These results indicate that SH-Alb can remodel the phenotype of macrophages, thereby affecting the intrahepatic microenvironment and delaying the process of liver fibrosis. It provides a good foundation for the application of albumin in clinical treatment.
PURPOSE:To obtain a bathing agent for a jet bath having excellent skin cleaning effect and free from the troubles concerning foaming ability. CONSTITUTION:This bathing agent for a jet bath is composed mainly of a surfactant. The surfactant is selected from a nonionic surfactant, e.g. lauric acid diethanolamide, palm oil-fatty acid monoethanolamide, an anionic surfactant, e.g. sodium alpha-olefin sulfonate and sodium lauryl sulfate and an amphoteric surfactant, e.g. a carboxy betaine-type compound and an aminocarboxylic acid. However, an anionic surfactant is preferable from the point of view of foaming ability. Further, as a compounding ratio, the ratio which is free from a problem occurring in formulation is preferably selected.
Many factors influence outcomes following mastectomy and breast reconstruction. Cutaneous sensation, degree of scar formation, nipple projection and overall appearance are well correlated with patient satisfaction. However, very little data exists on the importance of skin temperature after mastectomy and reconstruction. Our investigators have noted that a number of patients report their reconstructed breast is cold and relate this as a source of dis-satisfaction. In these patients, it is unclear if 1) the reconstructed breast skin is cold and if so 2) can something can be done to improve this. Our investigators hypothesize that cutaneous breast temperature may be altered after mastectomy and reconstruction. This may be dependent on the reconstruction technique and other patient factors. In this pilot study, our investigators aim to establish techniques for evaluating cutaneous breast temperature following mastectomy and reconstruction. Our investigators hope to establish baseline data to develop an understanding of breast skin temperature after mastectomy and reconstruction.

Our long-term goals are to evaluate how cutaneous breast temperature may contribute to patient satisfaction. Our investigators also hope to determine which patients are at risk for developing a cold breast after surgery. Finally, our investigators will setup a prospective trial evaluating techniques to correct this problem and improve patient satisfaction.
Patients receive 4 mg/kg VEGF Trap IV over 1 hour on day 1. Treatment repeats every 14 days in the absence of disease progression or unacceptable toxicity.
Eight cycles of rituximab IV infusion (375 mg/m\^2; rituximab induction) in combination with up to 8 cycles of cyclophosphamide, doxorubicin, vincristine, prednisolone (CHOP) or cyclophosphamide, vincristine, prednisolone (CVP) chemotherapy (as per institutional practice) administered every 3 weeks. Participants achieving at least PR during induction, entered rituximab IV maintenance therapy (375 mg/m\^2) once every 8 weeks for 24 months.
All patients will receive Normosol or equivalent solution, 0.5 ml/kg/fasted hour IV (approximately from 8am to time of induction) during induction of anesthesia. All patients will then receive maintenance fluids consisting of Normosol or equivalent solution at 6 ml/kg/operative hour. After randomization occurs, those patients randomized to the Restricted Arm will continue to receive Normosol or equivalent solution at 6ml/kg/operative hour.
<P>PROBLEM TO BE SOLVED: To obtain a skin melanocyte proliferation inhibitor, a sunscreen agent and a bleaching agent, to prepare a sunscreen cosmetic or a bleaching cosmetic.  <P>SOLUTION: The melanocyte proliferation inhibitor utilizing an information-communicating mechanism from skin epidermal cells is characterized by containing an extract of Paeonia Lactiflora Pallas and/or Zizyphus jujuba Miller var. inermis Rehder. The sunscreen cosmetic or bleaching cosmetic contains the extract of Paeonia Lactiflora Pallas and / or Zizyphus jujuba Miller var. inermis Rehder as the melanocyte proliferation inhibitor.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Study participants will undergo imaging of both eyes with the AngioVue unit (approximately 60 seconds/eye), per standard operating protocol. Imaging is noncontact, and pharmacologic dilation will not be used for the purposes of this study. In most instances, study participants will undergo only a single imaging session on a single day. However, potential participants will be asked to consent for additional imaging sessions (up to 12) that may occur over the course of subsequent future visits to the clinic. Additionally, study participants will be asked to consent to prospective collection of clinical and demographic data, to correlate findings of OCT-A imaging to subsequent clinical course.
In each session, 20 ml of local anesthetic (1:100 mixture of 10 mg/mL procaine) was used. Local injections, C5-T8 segmental injections, trigger point injections of the forearm muscles and stellate ganglion injections were applied in each session, using a 27-gauge, 4-6 cm needle. The local injection was applied first in the first extensor compartment at the point of maximal tenderness and was directed proximally toward the radial styloid (3 mL of the mixture). Then the forearm muscles were investigated by palpation to determine the trigger points. If any trigger point was detected, approximately 5 mL lidocaine was injected to that point. C5-T8 segmental injections were applied intradermally to each spinous process and to 0.5-2 cm lateral of each process on the affected side (approximately 0.25-0.5 ml per injection). Finally, the stellate ganglion injection was applied using Fischer's modified technique. The sternocleidomastoid muscle was palpated by the physician between the middle and distal third, gently pulling the muscle laterally with the neurovascular bundle. Following palpation of the anterior tubercle of the transverse process of the sixth cervical vertebra, the cervical spine was extended and rotated 45° to the opposite side. The needle entry point was 1 mm below the tubercle, then the needle was directed 45° caudally, 45° medially and 45° dorsally. If the aspiration was negative, 3mL procaine was injected
Cytotoxic chemotherapeutic agents are defined by the AACR as traditional chemotherapy and have long been a mainstay of cancer treatment. Many of these drugs have been developed through screening natural substances. The efficacy of these drugs for non-small cell lung cancer was demonstrated by a 1995 meta-analysis, which showed an extension of survival time with cisplatin. Although numerous drugs have been developed, combinations such as carboplatin with paclitaxel and cisplatin with gemcitabine have been standard treatments. The development of molecularly targeted therapy represents a significant advance in the treatment of lung cancer, with EGFR inhibitors first approved in Japan. Predictive factors for therapeutic effect have been identified as specific abnormalities in the EGFR gene, and it has been shown that resistance due to secondary mutations in the gatekeeper region occurs, and that increasing specificity for genetic abnormalities enhances drug efficacy. Subsequently, genetic abnormalities causing multiple cancers have been identified, and corresponding drugs have been developed. Immunotherapy has shown the effectiveness of immune checkpoint inhibitors. In lung cancer, the therapeutic effect of PD-1/PD-L1 inhibitors was demonstrated early on. Currently, immunotherapy is standard treatment from the first-line for patients likely to respond well to it, and in combination with chemotherapy for others. Furthermore, as an adjunct to curative treatment, combinations of molecularly targeted therapy and immune checkpoint inhibitors have shown to extend survival. This indicates that a composite approach is beneficial for patient prognosis.
PURPOSE:To obtain a plaster base for external use, effective in preventing migration of active component to reverse face and having excellent stretchability and aira-permeability to suit for the protection of diseased part, by laminating a plurality of stretchable nonwoven cloths crossing the stretchable directions of the cloths with each other. CONSTITUTION:A plurality of stretchable nonwoven cloths 2,2',2a,2b,3 are laminated in a manner to cross the stretchable directions with each other. Preferably, the laminated nonwoven cloths 2 and 3, 2' and 3, and 2a, 2b and 3 are integrated with each other by needle-punching to obtain a base 1 for external plaster such as anti-inflammatory analgesic for external use. Since the obtained external plaster base is stretchable along multiple directions, it surely follows the stretch of skin without hindering the motion of the diseased part. There is no stuffing of the diseased part because all the nonwoven cloths constituting the base are aira-permeable. The multi-layer structure of the base is effective in preventing the migration of the drug active component to the reverse side.
Breeding new and sustainable crop cultivars of high yields and desirable traits has been a major challenge for ensuring food security for the growing global human population. For polyploid crops such as wheat, introducing genetic variation from wild relatives of its subgenomes is a key strategy to improve the quality of their breeding pools. Over the past decades, considerable progress has been made in speed breeding, genome sequencing, high-throughput phenotyping and genomics-assisted breeding, which now allows us to realize whole-genome introgression from wild relatives to modern crops. Here, we present a standardized protocol to rapidly introgress the entire genome of Aegilops tauschii, the progenitor of the D subgenome of bread wheat, into elite wheat backgrounds. This protocol integrates multiple modern high-throughput technologies and includes three major phases: development of synthetic octaploid wheat, generation of hexaploid A. tauschii-wheat introgression lines (A-WIs) and homozygosis of the generated A-WIs. Our approach readily generates stable introgression lines in 2 y, thus greatly accelerating the generation of A-WIs and the introduction of desirable genes from A. tauschii to wheat cultivars. These A-WIs are valuable for wheat-breeding programs and functional gene discovery. The current protocol can be easily modified and used for introgressing the genomes of wild relatives to other polyploid crops.
Progeroid disorders are a heterogenous group of rare and complex hereditary syndromes presenting with pleiotropic phenotypes associated with normal aging. Due to the large variation in clinical presentation the diseases pose a diagnostic challenge for clinicians which consequently restricts medical research. To accommodate the challenge, we compiled a list of known progeroid syndromes and calculated the mean prevalence of their associated phenotypes, defining what we term the 'progeria phenome'. The data were used to train a support vector machine that is available at https://www.mitodb.com and able to classify progerias based on phenotypes. Furthermore, this allowed us to investigate the correlation of progeroid syndromes and syndromes with various pathogenesis using hierarchical clustering algorithms and disease networks. We detected that ataxia-telangiectasia like disorder 2, spastic paraplegia 49 and Meier-Gorlin syndrome display strong association to progeroid syndromes, thereby implying that the syndromes are previously unrecognized progerias. In conclusion, our study has provided tools to evaluate the likelihood of a syndrome or patient being progeroid. This is a considerable step forward in our understanding of what constitutes a premature aging disorder and how to diagnose them.
Participants will receive 30 daily sessions of sham tDCS. Each session lasts 20 minutes, and the sham programming delivers 3 ramps of 30 seconds of active current, the first in the first minute of the session, the second after 10 minutes and the third at the last minute of the session.
The invention provides a transdermal absorption adhesive patch for curing onychomycosis. The adhesive patch comprises a back lining layer, a viscous polymer layer and a protective film layer, wherein the viscous polymer layer contains a medicine for curing onychomycosis, viscous polymer and a penetration enhancer, wherein the medicine is ciclopirox olamine, and the penetration enhancer is laurocapram or a traditional Chinese medicinal mixture with laurocapram. The invention also provides a preparation method of the adhesive patch. The adhesive patch of the invention can effectively promote ciclopirox olamine to penetrate the skin and realize the effect of curing onychomycosis. By adopting precutaneous administration, the gastrointestinal enzymolysis and the first-pass effect of the liver can be avoided, the toxic or side effects can be reduced and the individual differences of administration can be reduced. In addition, ciclopirox olamine in the adhesive patch can be released in a stable rate and the drug effect can be maintained stably for about 3 days, thus the frequency of use can be reduced. The raw materials of the adhesive patch of the invention are simple and accessible, the cost is cheap; and the adhesive patch is convenient to remove or paste and is also convenient to use, thus avoiding the pollution of clothes and the loss of medicines. Therefore, the adhesive patch of the invention has high practicability.
Pulsatile tinnitus is a rhythmic type of tinnitus. Most cases are caused by vascular disorders and present as synchronous with the patient's heartbeat. A dilated mastoid emissary vein may cause pulsatile tinnitus. Here, we report the first case of bilateral pulsatile tinnitus caused by dilated bilateral mastoid emissary vein. The patient suffered from bilateral pulsatile tinnitus for 2 years. His bilateral tinnitus disappeared temporarily when the bilateral mastoid processes were compressed. Temporal bone computed tomographic (CT) showed the bilateral dilated mastoid emissary canals. Cranial Magnetic resonance venograms (MRV) showed the bilateral dilated mastoid emissary veins. We explained the risk of surgery to the patient. Because the patient could tolerate his tinnitus and did not have a hemangioma or tumor, he did not choose to undergo surgery.
PROBLEM TO BE SOLVED: To obtain a cosmetic material such as a foundation and the likes without sticky feeling during and after applying it and excellent in durability of moisture-retaining effects and cosmetic effects. SOLUTION: This cosmetic material contains a pigment, the surface of which is coated with water soluble glucomannan. The coated pigment has 5-40 μm volume-average particle size measured by a dry type size distribution measuring device using laser. The amount of the water soluble glucomannan is preferably 0.1-5 wt.% based on the weight of the pigment. The amount of the coated pigment to be blended in the cosmetic material is preferably 0.1-99% based on the whole amount of the cosmetic material. The objective coated pigment is obtained by dissolving water soluble glucomannan in purified water, mixing the pigment with the aqueous solution, agitating the mixture to disperse the pigment, drying and pulverizing the mixture by a heating and drying method, etc.
Cathodal tDCS will be applied over the left DLPFC (F3) according to the 10-20 EEG electrode systems and the anode will be placed over the right supraorbital (Fp2), using rectangular saline-soaked sponge pads 35 cm2. The current intensity of 1.5 mA will flow continuously only 120 seconds. The electrode will be attached until the end of stimulation even the current flows only at the beginning.
Antiperspirant products and processes for forming antiperspirant products are provided. One antiperspirant product comprises a water-in-oil emulsion having a water phase and an oil phase. The water phase comprises an active antiperspirant compound and water. The oil phase comprises cetyl PEG/PPG-10/1 dimethicone and a hydrophobic carrier. One process comprises combining water and an active antiperspirant compound and heating the water and the active antiperspirant compound to form a water phase. A carrier, a high MW polyethylene, and cetyl PEG/PPG-10/1 dimethicone are combined, the polyethylene is melted and an oil phase is formed. The water phase and oil phase are mixed.
Coronary heart disease (CHD) is a significant health threat among veterans. Compared to their civilian counterparts, veterans experience greater disability, reinfarction, and mortality following myocardial infarction (MI) and other acute coronary syndromes (ACS). High rates of hypertension, diabetes, and cardiac risk behaviors (e.g., smoking) and low socioeconomic status (SES) further increase veterans' CHD-related morbidity and mortality. The proposed pilot project will establish the feasibility of a telehealth nursing intervention for veterans with CHD who are recovering from MI/ACS. The Veterans Heart Attack Representations Telehealth (Vet-HART) intervention is designed to promote adaptive conceptual change in veterans' beliefs (common sense models or representations) about CHD etiology and self-management and facilitate health behavior changes (e.g., smoking cessation, medication adherence, diet management, and increased physical activity). The long-term goal of this research program is to improve veterans' quality of life (QoL) and reduce their CHD-related morbidity/mortality. The proposed project is the requisite next step in attaining that goal.
BACKGROUND: Sepsis is perceived as lethal tissue damage and significantly increases mortality in combination with acute kidney injury (AKI). M2 macrophages play important roles in the secretion of anti-inflammatory and tissue repair mediators. We aimed to study the role of Dehydroandrographolide (Deh) in sepsis-associated AKI in vitro and in vivo through lipopolysaccharide (LPS)-induced macrophages model and cecal ligation and puncture-induced AKI mice model, and to reveal the mechanism related to M2 macrophage polarization.
METHODS: Enzyme-linked immunosorbent assay kits were used to assess the levels of inflammatory factors. Expression of markers related to M1 macrophages and M2 macrophages were analyzed. Additionally, dual specificity phosphatase 3 (DUSP3) expression was tested. Cell apoptosis was evaluated by flow cytometry analysis and terminal-deoxynucleotidyl transferase-mediated nick end labeling staining. Moreover, renal histological assessment was performed by using hematoxylin and eosin staining.
RESULTS: Deh reduced inflammation of THP-1-derived macrophages exposed to LPS. Besides, Deh induced the polarization of M1 macrophages to M2 and downregulated DUSP3 expression in THP-1-derived macrophages under LPS conditions. Further, DUSP3 overexpression reversed the impacts of Deh on the inflammation and M2 macrophages polarization of THP-1-derived macrophages stimulated by LPS. Additionally, human proximal tubular epithelial cells (HK-2) in the condition medium from DUSP3-overexpressed THP-1-derived macrophages treated with LPS and Deh displayed decreased viability and increased apoptosis and inflammation. The in vivo results suggested that Deh improved the renal function, ameliorated pathological injury, induced the polarization of M1 macrophages to M2, suppressed inflammation and apoptosis, and downregulated DUSP3 expression in sepsis-induced mice.
CONCLUSION: Deh facilitated M2 macrophage polarization by downregulating DUSP3 to inhibit septic AKI.
Functional constipation (FC) is a dysfunctional gastrointestinal disease with the main clinical manifestations of complex bowel movements, incomplete bowel movements, reduced frequency of bowel movements, and dry and hard stools, which seriously affect patients' quality of life and psychology. Electroacupuncture improves constipation by performing acupuncture on specific points in the body to accelerate intestinal peristalsis. Chinese medicine ironing therapy (CMIT) can warm up the meridians, accelerate local blood circulation, promote gastrointestinal dynamics, and accelerate gastric emptying. This study elaborated on the method and steps of electroacupuncture combined with CMIT for functional constipation, including patient selection, material preparation, operation procedure, postoperative care, and precautions. The therapeutic effect of the method was also evaluated. The results of the study showed that after 4 weeks of treatment, compared with Western medicine alone, electroacupuncture combined with CMIT can improve the frequency of FC patients' voluntary bowel movements, constipation, and quality of life. There were no obvious adverse reactions.
Participants randomized to the intervention arm will undergo the FAST program, a progressive safe-falling training based on the tuck and roll strategy. As part of the FAST program, participants will train 30 minutes twice a week for a period of four weeks under the supervision of a trained researcher. Participants will wear protective gear (knee, hip, head) and they will complete a 10-minute stretching exercise routine to minimize the risk of injury.