anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a liquid calcium soft capsule and a preparation method thereof, comprising a capsule skin and contents in the capsule body; the capsule shell comprises 30-50% of gelatin, 10-30% of glycerin, 30-50% of purified water and 1-4% of colorant; the content in the capsule body comprises 30-50% of calcium citrate, 1-5% of milk mineral salt, 0.1-3% of casein phosphopeptide, 30.01-2% of vitamin D and 40-60% of soybean oil. The invention takes calcium citrate as a main calcium source and takes milk mineral salt as a secondary calcium source. The calcium citrate is organic calcium, has absorption rate higher than inorganic calcium, and can increase citric acid content in urine, acidify urine, and inhibit calculus formation. The milk mineral salt is separated from milk, has small irritation to intestines and stomach, and the calcium supplement effect can not be reversed. The casein phosphopeptide is added to be combined with Ca2+ to form a soluble complex, and Ca2+ is prevented from precipitating in the small intestine with neutral or weak alkalinity, so that the absorption and utilization of Ca2+ by the small intestine epithelial cells are promoted. Vitamin D3 is a hormone precursor acting on calcium and phosphorus metabolism, and can improve the absorption of calcium and phosphorus by organism.
Individuals with type 1 diabetes and those with type 2 diabetes who are prescribed bolus insulin must decide on an insulin dose for any given meal. This dose is often based on what they are eating and their glucose value. Insulin bolus calculators may be helpful in recommending an insulin dose. This study examines the safety of an app-based insulin calculator manufactured by Welloc (Columbia, MD). This app uses the glucose value and trend arrow, in certain circumstances, to recommend a bolus insulin dose. This study is a single arm trial where continuous glucose monitoring metrics such as time in range will be measured before and after the study participants are given the app.
The optimum size of endotracheal tube (ETT) for general anaesthesia remains a matter of debate. Choice of ETT size may be of particular pertinence during thyroid surgery, for a number or reasons. Because of the strong attachments of the thyroid gland to the trachea, intraoperative mobilization of the thyroid will lead to inevitable movement of the trachea and larynx against the fixed ETT, with consequent risk of traumatic injury to tracheal mucosa, vocal cords, and arytenoids. Thus thyroidectomy is likely to be associated with a greater risk of laryngeal trauma related to the ETT than operations outside the Head and Neck region where there is no movement of the larynx. On top of this, postoperative vocal impairment comprises one of the most important concerns after thyroidectomy, usually attributed to impaired vocal fold function secondary to recurrent laryngeal nerve injury. However, post-thyroidectomy vocal impairment can also occur in cases where the recurrent laryngeal nerve is preserved. Thus, concerns regarding vocal outcomes after thyroidectomy tend to be foremost in the mind of both the surgeon and the patient, and any measures which can be taken to minimize post-thyroidectomy hoarseness, which might include choosing the optimal ETT size, would appear to constitute a worthwhile endeavor.

Laryngeal trauma due to endotracheal intubation is probably more common than appreciated, however, given that symptoms of sore throat and hoarseness after most operations are generally self-limiting, this is not usually a major cause of concern. On the other hand, postoperative vocal symptoms may be a major cause of anxiety after thyroidectomy, due to fear of damage to the recurrent laryngeal nerve or the external branch of the superior laryngeal nerve (SLN). Laryngeal trauma without impairment of vocal fold function has been reported to be a significant cause of vocal symptoms after thyroid surgery. However, no previously published study has attempted to correlate post-thyroidectomy vocal symptoms or signs of laryngeal trauma with ETT size.

The hypothesis of the present study was that intubation with a smaller size ETT would lead to less trauma to the larynx during thyroidectomy than intubation with a standard size tube, and this would be reflected through less postoperative throat symptoms and objective laryngeal alterations. The rationale for this hypothesis was that a smaller caliber tube would be less unyielding when the larynx is moved against it, and thus would lead to less laryngeal injury. In order to address this question, the investigators designed a randomized controlled trial, comparing the impact of intubation with a smaller size tube (size 6.5 for females, and size 7 for males) with that of intubation with ETTs of the standard size used in the investigators department (size 7.5 for females, and size 8 for males).
Participants receive busulfan IV over 2 hours and fludarabine IV over 30 minutes on days -5 to -2. Participants undergo HSCT on day 0. Participants then receive cyclophosphamide IV over 60 minutes on days 3 and 4.
BACKGROUND & AIMS: Echocardiographic findings may provide valuable information about the cardiac conditions in cirrhotic patients waiting for liver transplantation (LT). However, data on the ability of the different echocardiographic parameters to predict post-transplant risk of mortality are scarce and heterogeneous. This systematic review evaluates the role of different echocardiographic features as predictors of post-LT mortality. A meta-analysis was also performed according to the observed results.
METHODS: A systematic review was conducted according to PRISMA guidelines. Medline (PubMed) database was searched through February 2023 for relevant published original articles reporting the prognostic value of echocardiographic findings associated with outcomes of adult LT recipients. The risk of bias in included articles was assessed using ROBINS-E tool. Methodological quality varied from low to high across the risk of bias domains.
RESULTS: Twenty-three studies were identified after the selection process; ten were enrollable for the meta-analyses. According to the results observed, the E/A ratio fashioned as a continuous value (HR = 0.43, 95%CI = 0.25-0.76; P = 0.003), and tricuspid regurgitation (HR = 2.36, 95%CI = 1.05-5.31; P = 0.04) were relevant predicting variables for post-LT death. Other echocardiographic findings failed to merge with statistical relevance.
CONCLUSION: Tricuspid regurgitation and left ventricular diastolic dysfunction play a role in the prediction of post-LT death. More studies are needed to clarify further the impact of these echocardiographic features in the transplantation setting.
Participants will remain at rest in the supine position for 6 minutes. Participants in the experimental group will perform intermittent apneas at high lung volume with a density of 30 seconds, followed by a normal breath of 10 seconds (9 cycles of 30s apnea - 10s normal breathing, until completing the 6 minutes).
Functional neuroimaging and electrophysiological assessments can identify evidence of residual consciousness and cognition in patients with prolonged disorders of consciousness (PDOC) who are otherwise behaviourally unresponsive. These functional neurodiagnostics are increasingly available in clinical settings and are recommended by international clinical guidelines to reduce diagnostic and prognostic uncertainty, and thereby assist family caregivers in their best-interests decision-making. Nevertheless, little is known about how family caregivers make sense of the results of these state-of-the-art functional neurodiagnostics. By applying Interpretative Phenomenological Analysis (IPA) to interviews with family caregivers of patients with diagnoses of PDOC who had received a functional neurodiagnostic assessment, we identify three primary themes of sense-making: The special significance of "brain scans"; A dynamic sense-making process; Holding on to hope and holding on to the person. These themes highlight the challenges of helping family caregivers to balance the relative importance of functional neurodiagnostic results with other clinical assessments and identify an ability of family caregivers to hold a contradiction in which they hope for recovery but simultaneously express a rational understanding of evidence to the contrary. We offer several recommendations for the ways in which family caregivers can be better supported to make sense of the results of functional neurodiagnostics.
After receiving informed consent from the children and their families, the American Society of Anesthesiologists (ASA) 1-2 pediatric patients between 6 and 14 years who will be recruited for elective surgery will be included in this study. The children under the 5% percentile will be accepted as underweight. After, the basal gastric volume will be calculated with the help of Ultrasonography (USG). The children will receive oral 3 mL/kg 5% dextrose. USG evaluation will be made every 5 minutes until the gastric volume reaches the basal level. Children reaching basal gastric volume will be accepted as suitable for the surgery. This study compares the gastric volume and emptying time after ingesting 3 mL/kg clear fluid in underweight and average-weight pediatric patients in the pre-operative period.
Patients undergo standard of care treatment and collection of blood samples as in Group I. Patients then receive hepatitis A and tetanus toxoid vaccinations at month 9.
PURPOSE:To dry incense sticks in a short time and in a large quantity by putting incense sticks extruded from an extruder and then cut into required length and kept to undried state on a receiving sheet in a row, laminating plural receiving sheets thereof and charging the laminate into a cubic device for drying the sticks while sucking air. CONSTITUTION:A number of undried incense sticks 9 are put on a receiving plate 10 and plural sheets thereof are laminated while turning incense sticks in same direction to form the laminate 12. The laminate 12 is applied to an air introducing and opening part 3 provided on the side part of sucking device and the opening part is properly closed. Then air is sucked and water content of incense sticks 9 in the laminates 12 is removed by sucking and evacuating the water content to dry the incense sticks 9. The above-mentioned drying means are carried out in a remarkably short time independently to season and weather and the production efficiency of incense sticks can be remarkably improved. Further, since production thereof can be practiced in a narrow place of equipment, the method is advantageous. Besides, incense sticks are not warped and the cost of equipment is also reduced.
This study will involve two different physical activity conditions and a control condition. Each participant will undergo the three conditions in a random order. The first protocol involves 3 minutes of cycling on a stationary bike at moderate intensity every 30 minutes for 6 hours, totaling 36 minutes of cycling exercise. The second protocol involves 3 minutes of cycling on a stationary bike at moderate intensity every 15 minutes for 3 hours to match the total exercise duration in the first protocol. Participants will remain seated for 3 hours to match to the total time spent in the lab. For the control condition, participants will remain seated. For each condition, participants will be provided with two meals, one before the protocol and another one in the middle of the protocol. The meals will be purchased from the cafeteria on campus based on the participant's own choice as long as carbohydrates account for 55-65% of total calories. Participants will eat identical meals across the three conditions.
A process for the production of a transdermal therapeutic system, in which a first laminate web composed of a carrier layer, active layer with an active substance and further auxiliary and/or protective layers, is transferred either individually or in combination with at least one more layer section into a second web. Steps, with different phases of motion and stationary move both the first and second web forward. An active layer is always, in an inoperative phase of the webs, subdivided, in phases, into subdivisions; it is further transferred, vertically to the direction of the webs, to the second web after withdrawal of the carrier layer in predetermined spaces formed in the direction of the webs. An apparatus consists of a punching device with a punch (3) and holding-down clamp (5) positioned slidingly therein, in the direction vertical to the first web. A clamp device (4) is slidingly positioned between the punch (3) and holding-down clamp (5). A transfer device consisting of deflection rolls (10, 11) and dispenser edge (6) is positioned behind the holding-down clamp (5). Said dispenser edge (6) is connected mechanically to the clamp device (4) and the first deflection roll (10). The second web (2) is positioned, slidingly in the direction of the first web (1), behind the transfer device.
For Intravitreal Use via SUSVIMO ocular implant.

The SUSVIMO initial fill and ocular implant insertion and implant removal procedures must be performed under aseptic conditions by a physician experienced in vitreoretinal surgery. The SUSVIMO ocular implant must be surgically implanted in the eye or removed from the eye (if medically necessary) in an operating room using aseptic technique. See SUSVIMO Instructions for Use and the standardized steps to optimize surgical outcomes.

SUSVIMO refill-exchange procedures must be performed under aseptic conditions by a physician experienced in ophthalmic surgery [see Dosage and Administration (2.7)].

Do not administer SUSVIMO (ranibizumab injection) as a bolus intravitreal injection. Do not substitute SUSVIMO (ranibizumab injection) with other ranibizumab products.

Initial Fill: One SUSVIMO initial fill needle (34-gauge, with integrated 5 μm filter and blue cap) is included. A 5-micron sterile filter needle (19-gauge × 1½ inch), and a 1 mL Luer lock syringe are needed but not included.

Refill-Exchange: One SUSVIMO refill needle (34-gauge with integrated 5 μm filter and clear cap) is included. A 5-micron sterile filter needle (19-gauge × 1½ inch), and a 1 mL Luer lock syringe are needed but not included.
Circulating tumor DNA (ctDNA) is the cornerstone of liquid biopsy diagnostics, revealing clinically relevant genomic aberrations from blood of cancer patients. Genomic analysis of single circulating tumor cells (CTCs) could provide additional insights into intra-patient heterogeneity, but it requires whole-genome amplification (WGA) of DNA, which might introduce bias. Here, we describe a novel approach based on mass spectrometry for mutation detection from individual CTCs not requiring WGA and complex bioinformatics pipelines. After establishment of our protocol on tumor cell line-derived single cells, it was validated on CTCs of 33 metastatic melanoma patients and the mutations were compared to those obtained from tumor tissue and ctDNA. Although concordance with tumor tissue was superior for ctDNA over CTC analysis, a larger number of mutations were found within CTCs compared to ctDNA (p = 0.039), including mutations in melanoma driver genes, or those associated with resistance to therapy or metastasis. Thus, our results demonstrate proof-of-principle data that CTC analysis can provide clinically relevant genomic information that is not redundant to tumor tissue or ctDNA analysis.
Participants will receive matching placebo for up to 27 months (treatment period) in addition to an initial treatment of Standard of Care IOP- lowering therapy (prior to randomisation and start of trial treatment) . They will receive 1.5g/day for the first 6 weeks, then dose increase to 3.0g/day for remainder of the treatment period.
The invention discloses the extracting process and application of a single-ingredient total flavonoids active ingredient as well as a single-ingredient medicine of various dosage forms prepared by the extractive. The invention belongs to the field of medical technology. The invention combines the refinement of aqueous extraction and macroporous resin absorption with the refinement of polyamide resin absorption, thereby overcoming the defects existing in the prior preparation that the content of total flavonoids is low and the cost performance of the product is low. In the obtained extractive, the content of total flavonoids can reach 20 percent or higher after the aqueous extraction, 60 percent or higher after the absorptive separation of the macroporous resin and 90 percent or higher after the refinement of polyamide resin absorption. The extractive obtained in the invention can be developed into various dosage forms according to needs. Experiments of pharmacodynamics prove that the single-ingredient extractive in the invention has the effects of stopping bleeding, alleviating pain, activating blood circulation, dissolving stasis and diminishing inflammation. The content of total flavonoids is greatly increased and the cost performance is far higher than other similar single-ingredient medicines on the market. The theory and procedures of the invention are universally fit for the preparation and application of other plants containing total flavonoids.
A method for evaluating a hospital patient's risk of mortality includes collecting data from physiologic signals generated by patient monitors, physiologic signals of organ function, and demographic information for a patient. A measure of the variability of at least one of the physiologic signals is determined. Data and the measure of variability are analyzed to determine whether a value for a particular physiologic or demographic variable falls within a critical interval for the variable that indicates that the value is predictive of mortality or survival. Each time a value for a physiological or demographic variable for the patient falls within a critical interval, the occurrence of an event for the patient is recorded. The number of events for the patient is counted over a time period. Output perceptible by human user that indicates the patient's risk of mortality or likelihood of survival is generated based on the count.
Cataract is affecting over 95 million people worldwide and remains the leading cause of vision impairment and blindness. Cataract surgery is an effective method for restoring visual acuity (VA). With the advancement of cataract surgery technique and intraocular lenses (IOL) technologies, expectations of patients from cataract surgery have good vision at distance and near ranges without using spectacles. The standard IOLs design were monofocal, which offered only fixed focal distance. One of the main factors for dissatisfaction after monofocal pseudophakic eyes is lack of accommodation. Previous studies demonstrated that this problem can be resolved by using diffractive trifocal IOLs. Diffractive trifocal IOLs provide effective near, intermediate and distance visual restoration, and has been widely used in patients who want to achieve spectacle independence after surgery. However, some possible optical side effects of trifocal IOLs have been reported, including halos and other dysphotopsias, reduced contrast sensitivity (CS), glare disability, which can significantly affect visual quality and patient satisfaction. The purpose of the present study was to compare the clinical outcomes such as visual function, refraction errors and visual quality of patients undergoing cataract surgery with implantation of two different models of diffractive trifocal IOLs: RayOne Trifocal (Rayner IOL, Ltd.) and AcrySof IQ PanOptix (Alcon Laboratories, Inc.) IOL.
Embodiments provide computerized methods and systems for managing electronic health data. In some cases a health data management system includes at least a local processing module, a zone database module, and a global database module. The local processing module stores a patient health record and generates and transmits a patient data set based on the health record to the zone database module. In some cases the patient data set excludes one or more portions of the patient health record. The zone database module may send the patient data set to one or more additional local processing modules without sending the excluded portion of the patient health record. In some cases the excluded portion includes patient assessment data and the transmitted portion includes patient subjective, objective and/or plan data.
Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.
A wireless device for facilitating visualization of a state of a patient being monitored by monitoring equipment. The device includes a wireless network interface, a camera, and a touch-sensitive display. A processor is in communication with the wireless network interface, the camera, a memory and the touch-sensitive display over a system bus. The device wirelessly receives data representative of a state of a first physiological parameter of a patient over a time interval. The visualization data includes a plurality of visualization data values, each of the visualization data values being generated by a data visualization module of the data visualization server from multiple values of machine data produced by the monitoring equipment in connection with monitoring the first physiological parameter. A first portion of a monitoring screen displayed by the device includes a graphical representation of the visualization data over the time interval along with or more range indicators.
The day before their scheduled appointment, participants will be asked if they have completed a series of difficult health behaviors (e.g., whether they walked 3 miles yesterday, ate 4-6 servings of fruits and vegetables yesterday, and slept at least 9 hours the previous night). They will then be encouraged to get a flu shot at their appointment.