anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a Chinese medicinal prescription and a preparation, in particular to a Chinese medicinal prescription for treatment of anorexia in children at 3-10 years old, a preparation and a preparation method thereof. Specifically, radix pseudostellariae and bighead atractylodes rhizome can tonify middle energizer and invigorate qi, strengthen spleen and harmonize stomach; Poria cocos can excrete dampness and promote dieresis; indigo naturalis can clear away heat and toxic materials; medicated leaven and parched hawthorn fruits have the efficacy of strengthening spleen and harmonizing stomach, helping digestion and regulating middle energizer; clove can warm stomach and kidney; nutmeg has the efficacy of warming middle energizer and astringing intestine, promoting the circulation of qi and helping digestion; fructus toosendan can soothe liver, promote qi circulation and relieve pain; fructus amomi can dissipate dampness and promote appetite, warm spleen and stop diarrhea; ginger can promote appetite and arrest vomiting; jujubes can tonify middle energizer and invigorate qi, nourish blood and tranquillize the mind; and licorice has the efficacy of relieving spasm, moistening lung, removing toxin, and coordinating the properties of drugs. The prescription is applied to treatment of 105 cases, wherein cures 102 cases (after drug administration, symptoms disappear and the appetite is increased), improves 2 cases (symptoms are alleviated after drug administration), and has no effect on 1 case (no change occurs to the symptoms after drug administration). The total effective rate is 97.14%, the shortest treatment time is 6 days, and the longest is 27 days. The composition provided by the invention has very good clinical test effects, a total effective rate of more than 97%, and short treatment time. The shortest time is 6 days, and the longest time is 27 days. The composition provided by the invention can be prepared into granules, tablets and oral liquid convenient for patient children to take, and the preparation process is simple and easy to operate.
The TIRE IMT group will receive a tablet with the TIRE software installed and a PrO2® device through which they will train. Training consists of six levels (A-F) with six inspirations at each level for a total of 36 breaths. Recovery times between breaths range from 40 to 5 seconds as the subject advances each level. TIRE data will be stored in the tablet for subsequent interrogation and data retrieval.
PURPOSE:To obtain the subject composition,. comprising a WS7622A monosulfuric acid ester, etc., as an active ingredient, having inhibiting activity against human leukocytic elastase, excellent in treating effects and useful as a preventing and therapeutic agent for arthrosclerosis, etc. CONSTITUTION:The objective composition comprises WS7622A mono- or disulfuric acid ester of the formula, etc., or its pharmaceutically permissible salt as an active ingredient. Furthermore, this composition is preferred as a preventing and therapeutic agent for periodontitis, pulmonary fibrosis, chronic sinopulmonary infection, chronic obstructive pulmonary disease, diffuse panbronchiolitis, hydroa, shock, systemic lupus erythematosus(SLE), Crohn disease, disseminated intravascular coagulation (DICE, amniorrhexis (immature birth), ischemic reperfusion disorder and corneal cicatrization or proliferation of fibroblast. Its daily dose is 1-5g and preferably administered in 1 to 3 divided portions. The WS7622A mono- or disulfuric acid ester and salts thereof are new compounds.
While impaired executive functioning has been often reported in association with COVID-19 contagion, it is still unclear whether, and to what extent, executive deficits might be explained by an altered quality of sleep, that been also frequently reported in COVID-19 patients. On this basis, this project aims to investigate executive functioning abilities (primary outcome) in patients hospitalized for a COVID-19 contagion, while distinguishing between those with and without sleep fragmentation (quality of sleep; secondary outcome), compared with an age- and education matched control group of healthy individuals who did not experience contagion. To this purpose, 38 COVID-19 patients and 38 healthy controls will be administered questionnaires and cognitive tasks aimed to assess: a) executive functioning/inhibitory control (GoNogo task); b) quality of sleep (NOSAS; Insomnia Severity Index; Epworth sleepiness scale). Prefrontal electrical activity will be recorded with EEG in COVID-19 patients, and related to sleep and cognitive-executive metrics. Statistical analyses will be aimed to investigate: a) a possible decrease of executive skills in COVID-19 patients compared with healthy controls, and in COVID-19 patients with fragmented sleep compared with those with normal sleep; b) possible differences in the relationship between executive performance and quality of sleep across the three experimental groups; c) whether possible differences in such relationship relate to prefrontal brain activity in patients. The results of this study will provide novel insights into the consequences of COVID-19 at the cognitive level, thus informing about treatment strategies.
In the experimental arm ribociclib will be dosed on a flat scale of 600mg/day (corresponding to three 200mg tablets once daily, 3 week on, one week off). Anti-hormonal/endocrine treatment of choice of investigator: anastrozole, exemestane, letrozole, fulvestrant.
Provided herein is a method for determining cancer treatment using an immune-modulating therapy in a subject in need thereof. The method comprises assessing whether a lymphatic system in a subject is dysregulated. When the lymphatic system is dysregulated, a treatment for the lymphatic system is determined before a therapeutic amount of an immune-modulating therapy is administered to treat cancer in the subject. Alternatively, when the lymphatic system is dysregulated, an immune-modulating therapy is selected to treat cancer in the subject. The immune-modulating therapy is independent of immune-cell priming, antigen trafficking, antigen presentation, and any combination thereof. The subject may also be treated for cancer accordingly.
The invention discloses a medical care device for treating arm pain. The medical care device for treating arm pain comprises a care band. Hook-and-loop fasteners are arranged at the two ends of the care band, at least two vertical sliding grooves are formed in one side face of the care band, and a cavity is formed in the care band. A small motor is arranged in the cavity, a driving eccentric wheel is arranged on a main shaft of the small motor, a moving rod is arranged in the cavity, a reset spring is arranged between the moving rod and the side wall of the cavity, the reset spring and the small motor are symmetrically arranged at the two ends of the cavity, and the end of the moving rod abuts against the driving eccentric wheel. At least two transverse supporting rods are arranged on the side wall of the moving rod, arc concave parts are arranged at the ends of the transverse supporting rods, and rolling balls are arranged in the arc concave parts and arranged in the vertical sliding grooves. A charging interface and an adjusting knob connected with the small motor are arranged on the care band. The medical care device for treating arm pain is simple in structure, convenient and fast to operate and high in use stability, applicability and practicability.
Chronic intractable pain is a disorder with complicated causes. The patient's quality of life is significantly reduced as a result of the patient's ongoing discomfort and the necessity for lengthy therapies. When patients don't respond well to medicine or other non-surgical treatments, spinal cord stimulation (SCS) is one of the surgical methods employed. The safety and effectiveness of SCS have previously been confirmed in numerous trials as a well-researched and clinically used therapy. However, the adjustment of SCS is complicated and its optimal effect relies on long-term regular follow-up. With the development of the internet, the investigators put forward a new system with remote and wireless SCS devices. Together with an exclusively developed mobile phone application, patients will be able to record their daily pain state and monthly health condition and make customized stimulation settings accordingly. This study is aimed to test the feasibility of this new precise management system. All participants will be randomly assigned to either interventional or control group. Participants in control group will be asked to take the conventional follow-up. Participants in interventional group will be additionally asked to take self-assessment on daily pain state and monthly health condition. The investigators hypothesized that this self-involved, closely monitored, and precisely adjusted system can significantly improve patients' quality of life in the long term and cut down both the financial expenses and time cost.
The invention relates to a compound fungal polysaccharide preparation having functions of supporting healthy energy, strengthening spleen and stomach and boosting immunity. The preparation is mainly prepared from the following raw materials in percentage by weight: 10-50% of grifola frondosa, 10-50% of hericium erinaceus polysaccharide, 5-35% of ganoderma lucidum polysaccharide and 5-35% of pachymaran. Traditional Chinese medicine holds that supporting healthy energy is to build up healthful vital energy and consolidate essence, namely boosting the immunity, enhancing the disease resistance of a human body, preventing diseases and keeping away from sub-health. The grifola frondosa and the hericium erinaceus polysaccharide medicinal and edible fungal polysaccharides are capable of boosting immunity, protecting gastric mucosa, and improving such adverse reactions of tumor chemotherapy as lack of appetite, emesis, nausea and leucopenia. Traditional Chinese medicine thinks that lucid ganoderma (ganoderma lucidum polysaccharide) and poria cocos (pachymaran) can invigorate qi and strengthen spleen, and calm heart and nerves; modern researches prove that the preparation can boost immunity, resist tumors, assist in cancer therapy, and treat insomnia and dyspepsia. In conclusion, through rational combination of the four fungal polysaccharides, the preparation has clear functions of supporting healthy energy, strengthening spleen and stomach and boosting immunity, and has an obvious healthcare effect on sub-health; meanwhile, the preparation can be used for improving adverse reactions of tumor chemotherapy.
BACKGROUND/AIM: Pediatricians play an essential role in managing pediatric oral emergencies; hence, they should have accurate information on dental injuries. This study aimed to assess the knowledge level of pediatricians regarding traumatic dental injuries (TDI) and their awareness of the ToothSOS mobile application.
MATERIALS AND METHODS: A survey comprising 10 questions was created on Google forms, and the links were sent to the participants via electronic mail and a mobile application. The demographic characteristics and the knowledge level of pediatricians about TDI and their awareness of the ToothSOS mobile application were evaluated. The questions were prepared by following similar studies and the current guidelines of the International Association of Dental Traumatology.
RESULTS: A total of 229 pediatricians (74.2% female) participated in this study. The correct answer rates revealed statistical differences in terms of profession and experience on the following issues: the most frequently traumatized tooth, the preference of the antibiotic agent, and the management of avulsed primary tooth (p < .05). The decision to consult a dentist revealed statistical differences in the profession (p = .001). The correct answers on the correlation between the age group and dental trauma accompanied by soft tissue injuries showed statistical differences in experience (p = .005). Although none of the participants knew the ToothSOS application, 91.7% of them preferred using this tool in future practices. This rate was statistically higher in participants with an experience of more than 10 years (p = .013).
CONCLUSIONS: The knowledge level of pediatricians regarding dental trauma was found to be sufficient, except for the questions on avulsion injuries. However, the fact that the participants were unaware of the ToothSOS mobile application was the most considerable result of the study, and this finding highlighted the importance of informing pediatricians dealing with oral injuries regarding the latest updates on dental traumatology.
A mechanism is provided in a data processing system comprising a processor and a memory, the memory comprising instructions that are executed by the processor to specifically configure the processor to implement an intelligent personal assistant with a health behavior change engine. A user state monitoring component monitors a user state received from an intelligent personal assistant. The user state monitoring component generates a user data model data structure that represents a pattern of behavior of the user based on the monitored user state. A user state change detection component detects a change in user state. A state change analysis component analyzes the change in user state to determine whether to activate a dialog. A dialog generation component generates a health-based conversation dialog in response to the state change analysis component determining to activate the dialog. A communication component executes with the user via the intelligent personal assistant using the health-based conversation dialog.
Endolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere's disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. Endolymphatic hydrops also can occur after noise trauma and its presence correlates with cochlear synaptopathy, a form of hearing loss caused by reduced numbers of synapses between hair cells and auditory nerve fibers. Here we tested whether there is a mechanistic link between these two phenomena by using multimodal imaging techniques to analyze the cochleae of transgenic mice exposed to blast and osmotic challenge. In vivo cochlear imaging after blast exposure revealed dynamic increases in endolymph that involved hair cell mechanoelectrical transduction channel block but not the synaptic release of glutamate at the hair cell-auditory nerve synapse. In contrast, ex vivo and in vivo auditory nerve imaging revealed that synaptopathy requires glutamate release from hair cells but not endolymphatic hydrops. Thus, although endolymphatic hydrops and cochlear synaptopathy are both observed after noise exposure, one does not cause the other. They are simply co-existent sequelae that derive from the traumatic stimulation of hair cell stereociliary bundles. Importantly, these data argue that Meniere's disease derives from hair cell transduction channel blockade.
Childhood obesity is a persistent public health concern, and community-based interventions have become crucial for addressing it by engaging local communities and implementing comprehensive evidence-based strategies. The Catalyzing Communities intervention takes a "whole-of-community"approach to involve leaders from diverse sectors in thinking systematically about child healthy weights and implementing evidence-based solutions. Using systems thinking and the Getting to Equity framework to guide interview analysis, this study examines changes in participants' use of systems thinking concepts and health equity in 43 participants across four U.S. communities involved in the Catalyzing Communities intervention. Our findings reveal significant shifts in systems thinking concepts, as participants develop a deeper understanding of childhood obesity as a complex adaptive system, and system insights, as participants increasingly recognize the interconnections and leverage points within the system driving childhood obesity. Participants also experienced increases in health equity thinking and action, particularly when discussing social and structural determinants of health, commitment to targeted actions, and a focus on addressing barriers and enhancing resources. The intersection between systems insights and health equity action, such as explaining leverage points and interventions to reduce deterrents to health behaviors, suggests the need for systems thinking activities to be integrated into health equity planning. Future research is needed to develop measures to connect systems thinking concepts to health equity, and the impact of these to community-level policy, systems, and environmental changes in public health.
Depression, affecting individuals worldwide, is a prevalent mental disease, with an increasing incidence. Numerous studies have been conducted on depression, yet its pathogenesis remains elusive. Recent advancements in research indicate that disturbances in synaptic transmission, synaptic plasticity, and reduced neurotrophic factor expression significantly contribute to depression's pathogenesis. In our study, we utilized adult male C57BL/6J mice. Lipopolysaccharide (LPS) can induce both chronic and acute depression-like symptoms in mice, a widely used model for studying depression associated with inflammation. N-acetylcysteine (NAC) exhibits anti-inflammatory and ameliorative effects on depressive symptoms. This study sought to determine whether NAC use could mitigate inflammatory depressive behavior through the enhancement of synaptic transmission, synaptic plasticity, and increasing levels of brain-derived neurotrophic factor (BDNF). In this study, we discovered that in mice modeled with depression-like symptoms, the expression levels of dendrites, BDNF, and miniature excitatory postsynaptic potential (mEPSC) in glutamatergic neurons, as well as the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptors (AMPARs) GluA1 and GluA2 subunits, were significantly decreased. These findings suggest an impairment in the synaptic transmission of glutamatergic neurons. Following treatment with NAC, the previously mentioned levels improved, indicating an enhancement in both synaptic transmission and synaptic plasticity. Our results suggest that NAC exerts a protective effect on mouse models of inflammatory depression, potentially through the enhancement of synaptic transmission and plasticity, as well as the restoration of neurotrophic factor expression. These findings offer vital animal experimental evidence supporting NAC's role in mitigating inflammatory depressive behaviors.
PROBLEM TO BE SOLVED: To enable to obtain a safe and effective otitis-curing agent by containing vitamin E and squalane. SOLUTION: This otitis-curing agent comprises 0.1-99 wt.% of vitamin E and 0.1-99 wt.% of squalane and, when needed, it contains 0.001-20 wt.% of an antibiotic and 0.001-20 wt.% of an insecticidal disinfectant. It can be formulated in forms of liquid, cream, jelly, gel and emulsion. A dose is 10-50 μl/once for the liquid and 10-50 mg/once for the ointment in 1-4 times a day. Since the agent contains vitamin E and squalane, it can improve local inflammatory conditions in otitis media or external otitis. The otitis-curing agent added with the antibiotic and/or the insecticidal disinfectant is enhanced in its curing effect for infectious conditions of diseases.
Common respiratory viruses, including the human parainfluenza viruses, threaten human health seasonally and associate with the development of chronic lung diseases. Evidence suggests that these viruses can persist, but the sources of viral products in vivo and their impact on chronic respiratory diseases remain unknown. Using the murine parainfluenza virus Sendai, we demonstrate that viral protein and RNA persist in lung macrophages, type 2 innate lymphoid cells (ILC2s) and dendritic cells long after the infectious virus is cleared. Cells containing persistent viral protein expressed Th2 inflammation-related transcriptomic signatures associated with the development of chronic lung diseases, including asthma. Lineage tracing demonstrated that distinct functional groups of cells contribute to the chronic pathology. Importantly, targeted ablation of infected cells significantly ameliorated chronic lung disease. Overall, we identified persistent infection of innate immune cells as a key factor in the progression from acute to chronic lung disease after infection with parainfluenza virus.
A cardiology device comprises memory (3) capable of storing heart activity data. These data comprise a chronological series of amplitude values (32). This series corresponds to a raw form of measurement of heart activity. The device additionally comprises a processing unit (54). The heart activity data moreover comprise a second chronological series of amplitude values (34). This second series (34) corresponds to a reduced form of the heart activity measurement. The processing unit (54) is configured to construct a linear function by parts of the amplitude values of the second chronological series (34). The linear function is adjusted to the amplitude values of the chronological series (32), according to an optimization criterion. Each part of the linear function corresponds to a time interval of the chronological series. The processing unit (54) is moreover configured to calculate a probabilistic law relative to periods of heart activity, according to a stochastic model, to combine some of said time intervals in order to obtain, for resultant time intervals, a statistical distribution of time periods approaching said probabilistic law, and to deliver data relative to the resultant time intervals in the form of data relative to a heart rhythm.
A hormone calcitonin substantially free from parathormone and capable of reducing the level of calcium in the blood is prepared by extracting parathyroid tissue with water at a pH of between 6.5 and 7.5, boiling to precipitate protein impurities, filtering and adjusting the pH of the filtrate to 5.5 to 6.5 to precipitate crude calcitonin.  The crude calcitonin may be dissolved in water at pH 6.5 to 7.5 and purified by (a) dialipin or (b) addition of ethanol to at least 60% to precipitate impurities followed by ether to precipitate active calcitonin.  The preparation may also be obtained by perfusing live parathyroid tissue with a physiologically compatible fluid e.g. blood containing 12 to 15 mg of calcium per 100 ml i.e. 3 to 5 mg of calcium per ml. above normal.  The parathyroid tissue may be freshly dissected or may be the isolated thyroid-parathyroid gland of the living animal.
Constipation with serious complications has been reported following the use of AIMOVIG in the postmarketing setting. There were cases that required hospitalization, including cases where surgery was necessary. In a majority of these cases, the onset of constipation was reported after the first dose of AIMOVIG; however, patients have also presented with constipation later on in treatment. AIMOVIG was discontinued in most reported cases of constipation with serious complications. Constipation was one of the most common (up to 3%) adverse reactions reported in clinical studies [see Adverse Reactions (6.1)].

Monitor patients treated with AIMOVIG for severe constipation and manage as clinically appropriate [see Patient Counseling Information (17)]. The concurrent use of medications associated with decreased gastrointestinal motility may increase the risk for more severe constipation and the potential for constipation-related complications.
BCD-021 is a product code for bevacizumab biosimilar manufactured by CJSC BIOCAD, Russia. In this arm patients will receive 6 courses of treatment with BCD-021 in combination with carboplatin and paclitaxel. BCD-021 will be administered at a dose of 15 mg/kg as 90 min intravenous infusion every 3 weeks (on Day 1 of each course). Paclitaxel will be administered at a dose of 175 mg/m2 as 3 hour intravenous infusion every 3 weeks on Day 1 and carboplatin (AUC 6 mg/ml×min) as 15 - 30 min intravenous infusion just after paclitaxel every 3 weeks on Day 1.