anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A manufacturing method of the benzodiazepine derivative is provided to offer a simple production process and economic benefits not by using the expensive catalyst, and to safely mass-produce the high-yield of benzodiazepine derivative as there is not in danger of ignition or explosion. CONSTITUTION: A manufacturing method of the benzodiazepine derivative comprises the step of manufacturing the compound which is represented by the chemical formula 1 by the reduction reaction between a reducing agent and the compound represented by chemical formula 2. The above manufacturing method of the benzodiazepine derivative is performed by reacting the compound represented by chemical formula 2 with the reducing agent at a mol ratio of 1:0.5-1:10. The above reduction reaction occurs at 0 through 100°C. The above compound represented by chemical formula 2 is manufactured by cyclizing the compound represented by chemical formula 3 under the presence of base basic condition. The base is the one of the group comprised of sodium hydroxide and potassium hydroxide.
Alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) represent pathological conditions that include many distinct stages, potentially leading to the final stage of cirrhotic liver. To date, liver transplantation is the sole successful treatment with concomitant limitations related to donor organ shortage and the need of life-long immunosuppressive therapy. Recently, cell-based therapies for ALD and NAFLD have been proposed with mesenchymal stem/stromal cells (MSCs) as promising effectors. MSC therapeutic applications offer hepatoprotection, regulation of the inflammatory process and angiogenesis particularly in ALD and NAFLD pre-clinical disease models. Recent studies suggested that hepatospecific MSC-based therapies could benefit liver diseases by restoring liver function and decreasing inflammation and fibrosis. Similarly to solid-organ transplantation, limitations in MSC approaches include donor availability exacerbated by high number of cells and cell trapping into lungs. Herein, based on recent advances, we discuss the use of MSCs as a therapeutic approach for ALD and NAFLD and we provide the available information for the establishment of a framework toward a potential clinical application.
A portable user device, method and computer program provide rhythmic athletic training assist by tracking an athletic proficiency level of a user. A respective sport control affordance for a plurality of sports are presented on a user interface of the portable user device. In response to a user selection of one sport control affordance associated with a selected sport, more than one drill control affordance for a type of athletic drill associated with the selected sport are presented on the user interface. In response to a user selection of a particular drill control affordance for a particular type of athletic drill, the type of athletic drill is associated with two or more available rhythmic speed settings. Based upon the tracked proficiency level of the user, one of the two or more rhythmic speed settings is selected. Video/audio guide is presented on the user interface at the selected rhythmic speed setting.
Topical PRK 124 (Pyratine-6)(0.125%) moisturizing lotion applied twice daily to the face for 48 weeks. Subjects will wash their faces prior to application. The applications will occur in the mornings and one hour before bedtime.
The thrombotic events are increasingly recognized complications of hematopoietic cell transplantation (HCT) associated with significant morbidity and mortality, which include transplantation-associated thrombotic microangiopathy (TA-TMA), sinusoidal obstructive syndrome (SOS), deep vein thrombosis (DVT), pulmonary thromboembolism (PTE), catheter-related thrombosis (CRT), superficial vein thrombosis (SVT), etc. There is a complex interplay on balancing the risk for thrombosis and bleeding in these patients, making treatment decisions particularly challenging. Emerging studies revealed that endothelial injury is the common underlying mechanism among different thrombotic disorders. There is increasing data that N-acetyl-cysteine (NAC) may prevent or improve endothelial dysfunction by inhibiting ROS production and preventing endothelial apoptosis. Our previous study showed low dose NAC could decrease the incidence of TA-TMA. In this study, we aim to assess the the efficiency and safety of N-acetylcysteine for prevention of thrombotic events after allogenic hematopoietic stem cell transplantation.
<P>PROBLEM TO BE SOLVED: To compound a cosmetic with high mol. wt. pectin originated from plant cells to give a stable viscosity little affected by the concentration of a salt.  <P>SOLUTION: It has been found that higher mol. wt. pectin than conventional pectin is obtained by a plant cell culture and a stable viscosity not affected by the concentration of a salt is obtained by adding the higher mol. wt. pectin to a cosmetic or the like.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Surgically removed cysts, and collected intracystic fluids and cerebrospinal fluid for histological and molecular analyses. Samples will be collected during the surgery and will be cryo-protected for further analyses. All subjects will enroll for intensive rehabilitation 60 days after surgery.
Infants were first offered oral feedings beginning at 32 weeks PMA. They were offered 8 oral feedings every day, at each of 8 scheduled daily feedings.
Anal fissure (AF) is common among children attending pediatric and surgery clinics and is frequently associated with painful defecation, stool withholding and constipation which affect 1%-30% of the pediatric population. Constipated children consume low fiber diets, come from lower socioeconomic families and tend to be obese. The reason why anal fissure develops is still largely unclear, however the pathogenesis points to an initial anal trauma cause by the hard stool leading to anal sphincter hypertonia or spasm which cause local ischemia and non-healing ulcer. It is not clear why the posterior anal canal is the most affected part by the local anal ischemia.

Current medical therapy for chronic anal fissure focuses on alleviating the two main pathologies by using anal sphincter relaxing topical ointments and laxative to treat associated constipation. The classical text book described treatment of AF focus on increasing fiber intake to treat the underlying constipation. Jensen et al, has found that treating the first episode of anal fissure with bran is more effective than local anesthetic or steroids. The American Society of Colon and Rectal Surgeons practice parameters suggest that increase in fluid and fiber ingestion, use of sitz baths, and if necessary use of stool softeners are safe have few side effects and should be the initial therapy for all patients with anal fissure.

There have been many recent randomized trials describing the effectiveness of Nitroglycerin (NTG), Botulinum toxin injection or the topical calcium channel blockers such as Diltiazem (DTZ) in adult and pediatric. A systematic review of the available randomized trials of these agents has shown that topical agents are marginally better than placebo \[15\]. Furthermore, in most trials that have demonstrated the effectiveness of topical agents laxatives usage was either not well controlled or lactulose was the main agent used. In children, many recent randomized trials have demonstrated the superior effectiveness of PEG over lactulose consequently; we think that treating AF with PEG is likely to improve the success rate and lead to persistent log-term fissure healing. Most adults and pediatric RCTs that have demonstrated the effectiveness of topical agents in healing AF, have focused on comparing various topical agents to placebo in treating AF, however the effectiveness in comparison to placebo has never been demonstrated in patients how are placed on more effective laxative such as PEG. We hypothesize that replacing lactulose with a more effective laxative such PEG as a sole agent to treat AF can eliminate the effectiveness and therefore the need to add topical sphincter relaxing agent such DTZ or NTG. Laxative-only treatment is likely to be more convenient and more cost-effective.
Since its introduction, the number of heart surgeries has risen continuously. It is a high-risk procedure, usually involving cardiopulmonary bypass, which is associated with an inflammatory reaction that can lead to perioperative and postoperative organ dysfunction. The extent of complications following cardiac surgery has been the focus of interest for several years because of their impact on patient outcomes. Recently, numerous scientific efforts have been made to uncover the complex mechanisms of interaction between inflammation, oxidative stress, and endothelial dysfunction that occur after cardiac surgery. Numerous factors, such as surgical and anesthetic techniques, hypervolemia and hypovolemia, hypothermia, and various drugs used during cardiac surgery trigger the development of systemic inflammatory response and the release of oxidative species. They affect the endothelium, especially endothelial glycocalyx (EG), a thin surface endothelial layer responsible for vascular hemostasis, its permeability and the interaction between leukocytes and endothelium. This review highlights the current knowledge of the molecular mechanisms involved in endothelial dysfunction, particularly in the degradation of EG. In addition, the major inflammatory events and oxidative stress responses that occur in cardiac surgery, their interaction with EG, and the clinical implications of these events have been summarized and discussed in detail. A better understanding of the complex molecular mechanisms underlying cardiac surgery, leading to endothelial dysfunction, is needed to improve patient management during and after surgery and to develop effective strategies to prevent adverse outcomes that complicate recovery.
The invention relates to novel erythromycin derivatives, particularly ones with novel C-13 R13 substituents, and to pharmaceutically acceptable salts thereof. The compound of this invention are useful as antibacterial agents and antiprotozoa agents and for other applications (e. g. anticancer, atherosclerosis, gastric mobility reduction, etc.) in mammals, including man, as well as fish and birds. The invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial protozoa infections by administering such compounds. The invention also relates to methods of preparing such compounds and to intermediates useful in such preparation. 32 claims
A standard enteral feed commonly used in practice. Nutricomp Soy Fibre (B.Braun). 300mls administered nasogastrically over one hour.
A current sensor may take measurements of electrical currents that flow between two limbs of a patient through at least a portion of the patient's torso. The current measurements may be taken during a single diagnostic session while the patient holds a ground electrode in a hand of one limb and a probe electrode is sequentially placed at different locations on the distal portions of other limbs. Each of the measurement locations may be an acupuncture point. An electrical current state for the diagnostic session may be calculated. This state may consist of current ranges for one or more electrical currents that are measured during the session. A lookup table may be employed to determine one or more medical conditions that are indicated by the current state. Alternatively, a trained machine learning model may predict, based on the measured currents, one or more medical conditions.
Tumor treatment vaccine(TTV) would be given deep subcutaneously in the arm or near the tumor. Use PD-1/L1 inhibitors in accordance with the drug indication.
NEW MATERIAL:4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate of formulaI. USE:A drug for treating diseases caused by thromboxane A2. It is low-toxicity and useful for treating inflammation, hypertension, thrombosis, cardiopathy or asthma. This hydrochloride monohydrate solves various kinds of medical problems caused by its anhydrous derivative. Its dose is orally 1-1,000mg/man/ day and parenterally 0.1-100mg/man/day. PREPARATION:4-(1-Imidazolylmethyl)cinnamic acid hydrochloride is recrystallized from water or an aqueous organic solvent such as aqueous acetone or aqueous ethanol to give the compound of formulaI. The content of water in the aqueous solvent is preferably 10-25vol% in order to increase the yield.
[JP57131769A]
PURPOSE: To obtain an immunorejection suppressing agent capable of suppressing immunorejection after organ transplantation, etc., and having little side effect by compounding amrinone as an active component. CONSTITUTION: This immunorejection suppressing agent contains amlinon, which is called by a chemical name of 5-amino-(3,4'-bipyridine)-6(1H)-one and has cardiotonic effect, as an active component. The agent is formulated into an oral preparation, an injection, etc., by a conventional method. In the case of oral administration, this is administered at a daily dose of 1-20mg/kg in one or several divided doses. In the case of parenteral administration, preferably the agent is administered at 0.5-10mg/kg/day by intravenous injection and at 0.05-33mg/kg/hr by intravenous drip infusion. Especially, in the case of acute cardiac insufficiency, it is administered at a single dose of 1mg/kg by intravenous injection and at 0.3-0.9mg/kg/hr by intravenous drip infusion.  After the transplantation of heart, kidney, bone marrow, liver, pancreas, etc., immunorejection is suppressed by administering the amurinone. This is especially effective after heart transplantation. This immunorejection suppressing agent has a completely different structure from those of agents such as ciclosporin and corticosteroid.
Magnesium sulfate is, generally, applied in order to alleviate or to avoid seizures. It can be administered according to many medical approaches. Nevertheless, at Rajavithi Hospital, the recommended administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour (Zudpan regimen). The therapeutic index of magnesium is in the range of 4.8-8.4 mg/dL. After that, the level of magnesium sulfate will be evaluated every 4 or 6 hours.

At Rajavithi Hospital, there are a lot of patients having pre-eclampsia symptom and many patients, who were received magnesium sulfate in the treatment, having the level of magnesium sulfate lower than the therapuetic level and needed to increase the maintenance dose to 2.5 grams/hour. Therefore, this work aims to studying the amount of magnesium sulfate administered to pregnant woman with pre-eclampsia symptom who possess high body mass index (BMI), especially for BMI greater than or equal to 30 kg/m2.
In advanced (Extraction Defect Sounding Class 3-4) alveolar defects, a minimally invasive tunnelised socket preservation technique utilising long term resorbable membranes and connective tissue grafting was used for extraction site development (XSD). The novel technique was evaluated in a retrospective comparative case series study including a total of 54 extraction sites. In the test group, out of 33 single rooted teeth, 29 in the maxilla and 4 in the mandible were removed, extractions sites were treated by the XSD method. Out of 33 teeth, 27 were incisors, 2 canines and 4 premolars. In the control group, out of 21 single rooted teeth, 11 in the maxilla and 10 in the mandible were extracted and left for spontaneous healing. Out of 21 teeth, 13 were incisors, 2 canines and 6 premolars. CBCT scans were taken prior to tooth extraction and 6-9 months later in both groups. Radiographic evaluation was carried out using the I-CAT Vision (Imaging Sciences International, LLC; Hatfield, USA) and ImageJ (National Institutes of Health) softwares. Following manual alignment of CBCTs vertical and horizontal linear measurements as well as planimetric measurements of cross-section areas were performed in pre- and postoperative data sets at the extraction sites.
An abundance of laboratory-based experiments has described a vigilance decrement of reducing accuracy to detect targets with time on task, but there are few real-world studies, none of which have previously controlled the environment to control for bias. We describe accuracy in clinical practice for 360 experts who examined >1 million women's mammograms for signs of cancer, whilst controlling for potential biases. The vigilance decrement pattern was not observed. Instead, test accuracy improved over time, through a reduction in false alarms and an increase in speed, with no significant change in sensitivity. The multiple-decision model explains why experts miss targets in low prevalence settings through a change in decision threshold and search quit threshold and propose it should be adapted to explain these observed patterns of accuracy with time on task. What is typically thought of as standard and robust research findings in controlled laboratory settings may not directly apply to real-world environments and instead large, controlled studies in relevant environments are needed.
Injection of 20% dextrose (50 % dextrose diluted with 0.5% lidocaine) into the rotator cuff tendinous insertions as well as into the tear. All injections are performed under ultrasound.
NEW MATERIAL:A compound expressed by formula I (R is expressed by formula II, formula III or formula IV). EXAMPLE:3-(3,4-dihydroxyphenyl)-1-(3-phenoxyphenyl)-2-propen-1-one. USE:Useful as a vascular hypertrophy-preventive agent. The agent is useful as a restenosis-preventive agent after a percutaneous coronary artery-dilating operation or a therapeutic agent of arterial sclerosis. PREPARATION:3-(3,4-dimethoxymethoxyphenyl)-1-(3-phenoxyphenyl)-2-prope n-1-one is dissolved in acetic acid and stirred under heating at 80 deg.C for 4hr, then extracted with ethyl acetate containing water. The ethyl acetate layer is washed with saturated saline solution and dried with anhydrous magnesium sulfate, then the solvent is distilled away under reduced pressure, the resultant residue is recrystallized by ethyl acetate-hexane to afford the compound expressed by formula I.
PURPOSE: A comprehensive understanding of neural distribution within the vastus medialis is crucial for the effective administration of botulinum neurotoxin injections to manage spasticity. The aim of this study was to develop an anatomically informed approach to guide the administration of botulinum neurotoxin injections into the vastus medialis muscle.
METHODS: Using a modified Sihler's method, we examined the vastus medialis muscles (20 specimens) to delineate the distribution of nerves relative to a transverse line extending from the anterior superior iliac spine to the base of patella. The vastus medialis muscle was divided into 10 areas from top to bottom. Then, using two fresh cadavers, ultrasonography-guided injections were performed based on the distribution of nerves within the vastus medialis. Each specimen was subsequently dissected to verify if the dye was accurately directed to the most densely innervated regions of the vastus medialis and to assess the precision of the injections.
RESULTS: The intramuscular nerve distribution within the vastus medialis muscle showed distinct patterns, particularly in areas between 6 and 9. Four injections were successfully administered on each side, targeting the regions between 6 and 9 of the vastus medialis. Upon dissection of the cadavers, the dye was found to be distributed along the muscle fiber.
CONCLUSION: We recommend targeting botulinum neurotoxin injections toward regions displaying a prominent nerve distribution, specifically focusing on areas between 6 and 9. By adhering to these guidelines, clinicians can minimize doses and mitigate potential adverse effects, such as gait disturbances, antibody development, and bruising, resulting from multiple injections. Furthermore, these findings can be incorporated into electromyography practices.
BACKGROUND: Elevated serum pro-inflammatory molecules have been reported in early psychosis. What is not known is whether peripheral inflammatory biomarkers are associated with CNS biomarkers. In the brain, release of pro-inflammatory molecules by microglial hyperactivity may lead to neuronal apoptosis seen in neurodegenerative disorders and account for loss of brain tissue observed in psychotic disorders. Neurochemical changes, including elevated glutamate levels, are also associated with neuroinflammation, present in early psychosis and change with antipsychotic treatment.
METHODS: Antipsychotic naïve patients with first episode psychosis (FEP) were studied as part of a collaborative project of neuroinflammation. In Study 1 we explored associations between plasma inflammatory molecules and neurometabolites in the dorsal caudate using magnetic resonance spectroscopy (1H-MRS) in N = 13 FEP participants. Study 2 examined the relationship between inflammatory molecules in the Plasma and CSF in N = 20 FEP participants.
RESULTS: In Study 1, the proinflammatory chemokine MDC/CCL22 and IL10 were significantly positively correlated with Glutamate and Glx (glutamate + glutamine) levels in the dorsal caudate. In Study 2, plasma inflammatory molecules (MIP1β/CCL4, MCP1/CCL2, Eotaxin-1/CCL11 and TNFα) were significantly correlated with CSF MIP1β/CCL4, IL10, MCP1/CCL2 and Fractalkine/CX3CL1 and symptoms ratings.
DISCUSSION: Plasma inflammatory biomarkers are elevated in early psychosis, associated with neurochemical markers as well as CSF inflammatory molecules found in neurodegenerative disorders. Future studies are needed that combine both peripheral and central biomarkers in both FEP and HC to better understand a potential neuroinflammatory subtype of psychosis likely to respond to targeted interventions.
The present invention relates to Taiwan lettuce health care tea capable of tranquilization and decompression, which is used for treating heart, brain and kidney complications due to hypertension. The present invention is prepared from the following components by weight: 600 to 1000 g of lettuce tea, 400 to 600 g of wildcelery herb root, 300 to 600g of wildcelery herb leaf, 250 to 450 g of dried lotus rhizome node, 400 to 600 g of Chinese taxillus twig, 300 to 500 g of dried cucumber stem, 400 to 800 g of feverfew, 350 to 650 g of lotus leaf, 100 to 400 g of scutellaria root, 100 to 400 g of semen cassiae, 100 to 400 g of common anemarrhena rhizome and 150 to 350 g of plantain seed. The present invention utilizes traditional Chinese medicine of lettuce tea, wildcelery herb root, Chinese taxillus twig, feverfew, etc. to prepare tea preparation for administration of patients; the medicine is admitted for 3 to 4 times a day, patients administer one pack of medicine each time, half a month is one course of treatment, patients can administer the medicine for 1 to 3 periods of courses of treatment according to the states of illness, and patients reduce medicine administration dosages for keeping health after the blood pressure is stable. Clinical experiments prove that the cure rate is 95%, and the present invention has the advantages of convenient administration, no side effect, etc. The present invention is pure traditional Chinese medicine preparation with good curative effects.