anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIMS: To evaluate the efficacy and safety of 0.01% atropine eye-drops in controlling myopia progression over 5 years.
METHODS: Experimental, analytical, prospective, randomised and longitudinal study, in 361 right eyes from 361 children randomised into the control group (177 eyes without treatment) and treatment group (184 eyes with 0.01% atropine eye-drops). Children assigned to the treatment group used 0.01% atropine once a day every night and the control group's children did not use any treatment or placebo. All the subjects completed an eye examination every 6 months for the 5 years of follow-up. The examination included subjective and objective refraction with cycloplegia, axial length (AL), keratometry and anterior chamber depth (ACD) to evaluate the efficacy of the treatment. It also included the anterior and posterior pole examination to evaluate the safety of the treatment.
RESULTS: The SE increased -0.63±0.42D in children after 5 years of treatment with 0.01% atropine, while in the control group the increase was -0.92±0.56D. AL increased 0.26±0.28 mm in the treatment group compared with 0.49±0.34 mm in the control group. Atropine 0.01% showed an efficacy of 31.5% and 46.9% in the control of the SE and AL increase, respectively. ACD and keratometry did not have significant changes between groups.
CONCLUSIONS: Atropine 0.01% is effective in slowing myopia progression in a European population. There were no side effects after 5 years of 0.01% atropine.
PURPOSE:A remedy and preventive for peptic ulcer having strong inhibitory activity against secretion of gastric juice, excellent antiulcer action and low toxicity, containing H chain of human IgG as an active ingredient. CONSTITUTION:A remedy and preventive for peptic ulcer containing H chain of human IgG as an active ingredient. The H chain is a polypeptide chain having 50,000+ or -1,500 molecular weight obtained by scissoring disulfide bond of IgG from IgG derived from human. This time, H chain is found newly to have antipeptic ulcer action. Namely, it has strong inhibitory activity against secretion of gastric juice. Powder, tablet, and capsule for oral medication, liposome preparation, intravenous injection or intramuscular injection is used as the form of medication. The preventive has low toxicity, excellent pharmaceutical effect, and is useful as a drug for remedying and preventing ulcer. A dose is preferably 1- 100mg/kg/day/adult.
BACKGROUND: Growth charts are an important method for evaluating a child's health, growth, and nutritional status. It is essential to monitor the growth of children and adolescents using growth charts.
OBJECTIVES: To present body mass index (BMI)-for-age references reflecting children's growth in Shanxi. We also compare our new data with growth references of other cities of China and World Health Organization (WHO) growth standards.
METHODS: A stratified cluster random sampling method was used to recruit 5461 children and adolescents aged 6-17 years. Height and weight were measured and BMI was calculated. The LMS method was used to calculate the percentile values of body mass index by sex and age. Smoothed BMI-for-age growth curves were presented for both sexes and compared with reference data from other cities of China and WHO.
RESULTS: BMI centiles increased with age but with different patterns in both boys and girls. The centile curves from the 3rd to the 50th had a slight increase, while a sharp increase was seen from 11 to 17 years in boys and from 6 to 14 years in girls in the higher centiles. In comparison with other cities of China, the values for the 50th percentile are higher than those reported for children from China 2009, Shanghai, Changsha and China 2010 in both sexes. In comparison with WHO growth references, Chinese girls and boys had higher values in all percentiles, whereas curves of girls look roughly the same. The medians for BMI in Shanxi increase linearly from 6 to 17 years in boys.
CONCLUSIONS: The BMI percentiles of children aged 6-17 years in Shanxi differed significantly from the growth reference curves of other cities of China and WHO. Recommending the provision of BMI reference curves for local children and adolescents to assess their growth and development and monitor their nutritional status. Early detection of overweight and obesity in children provides a scientific basis for the prevention and control of overweight and obesity in children.
Obstruction of the urinary tract can increase pelvi-ureteric pressure and thus cause renal colic pain, which can be very severe. Conventional therapy consists of non-steroidal anti-inflammatory drugs (NSAIDs) and opioids. NSAIDs have many side effects and opioids are not always available. In addition, the intravenous form of NSAIDs is not routinely available in Iran, and the drug is mainly used in the form of suppository. Due to these reasons, research on newer replacement therapies with fewer side effects is necessary. Desmopressin intranasal spray has already been shown to be partially effective in renal colic pain in a few studies. Due to its lower side effects, we decided to conduct a clinical trial with desmopressin to evaluate pain relief in renal colic. In this study, eighty-eight patients with acute renal colic pain, referring to Imam Khomeini Hospital in Tehran, will be randomly allocated to receive either intranasal desmopressin or placebo. Both groups will also receive 100 milligram indomethacin suppository. Pain intensity will be assessed and recorded using a verbal numeric rating scale, before nasal spray, and in minutes 5, 10, 15, 30, 45 and 60 after receiving the allocated treatment. Possible side effects will also be asked and recorded. The patient and the investigator responsible for recording pain intensity will not be aware of the administered drug. The results will be compared before and after treatment in each group, using appropriate statistical tests.
The function of the chloride channel ClC-1 is crucial for the control of muscle excitability. Thus, reduction of ClC-1 functions by CLCN1 mutations leads to myotonia congenita. Many different animal models have contributed to understanding the myotonia pathophysiology. However, these models do not allow in vivo screening of potentially therapeutic drugs, as the zebrafish model does. In this work, we identified and characterized the two zebrafish orthologues (clc-1a and clc-1b) of the ClC-1 channel. Both channels are mostly expressed in the skeletal muscle as revealed by RT-PCR, western blot, and electrophysiological recordings of myotubes, and clc-1a is predominantly expressed in adult stages. Characterization in Xenopus oocytes shows that the zebrafish channels display similar anion selectivity and voltage dependence to their human counterparts. However, they show reduced sensitivity to the inhibitor 9-anthracenecarboxylic acid (9-AC), and acidic pH inverts the voltage dependence of activation. Reduction of clc-1a/b expression hampers spontaneous and mechanically stimulated movement, which could be reverted by expression of human ClC-1 but not by some ClC-1 containing myotonia mutations. Treatment of clc-1-depleted zebrafish with mexiletine, a typical drug used in human myotonia, improves the motor behaviour. Our work extends the repertoire of ClC channels to evolutionary structure-function studies and proposes the zebrafish clcn1 crispant model as a simple tool to find novel therapies for myotonia. KEY POINTS: We have identified two orthologues of ClC-1 in zebrafish (clc-1a and clc-1b) which are mostly expressed in skeletal muscle at different developmental stages. Functional characterization of the activity of these channels reveals many similitudes with their mammalian counterparts, although they are less sensitive to 9-AC and acidic pH inverts their voltage dependence of gating. Reduction of clc-1a/b expression hampers spontaneous and mechanically stimulated movement which could be reverted by expression of human ClC-1. Myotonia-like symptoms caused by clc-1a/b depletion can be reverted by mexiletine, suggesting that this model could be used to find novel therapies for myotonia.
Conversion factor of Mirapex to Requip 24-Hour of 1:3. This was a switch study in which the conversion factor was being investigated to assist in the conversion from Mirapex to Requip PR. In this group, the dose of Requip PR was 3 times the dose of Mirapex.
PROBLEM TO BE SOLVED: To obtain a cleansing agent composition suitable for eliminating a make-up cosmetic, comprising a carboxylic acid type anionic surfactant, a specific compound and a prescibed cellulose essential components, by setting the pH of the mixture in a fixed range. SOLUTION: This cleansing agent composition is obtained by combining (A) a carboxylic acid type anionic surfactant with (B) a compound of formula I, formula II or formula III and (C) a cationic cellulose of formula IV (R<1> to R<6> are each H, methyl, ethyl, hydroxyethyl or hydroxypropyl; (n) is tens to several hundred thousand) or formula V (R<7> to R<9> are each H, etc.; (t) is tens to several hundred thousand) and adjusting the mixture to pH 7.5-8.5. A fatty acid soap is preferable as the component A and the amount of the component A blended is preferably 2-30wt.%, especially about 5-25wt.%. The amount of the component B blended is preferably 2-40wt.%, especially about 3-30wt.%. For example, methyl cellulose may be cited as the cellulose of formula IV in the component C and the amount of the component C blended is preferably 0.1-10wt.%, especially about 0.5-5wt.%.
The invention discloses a Chinese herb preparation for treating rheumatism and heumatism. The preparation is prepared by experts Qi Yuanguo and Hou Fuguo according to the theory that 'The evil are up, the gas must be false'. Tonification and counteracting are achieved in combination, 'tonification' exists in 'counteracting', 'counteracting' exists in 'tonification', and the body deficiency is tonified, the body pathogen is counteracted. Components of elecampane, ligusticum wallichii, salvia miltiorrhiza, liquorice, medlar, large-leaved gentian, Chinese angelica, dried rehamnnia roots, prepared rehmannia roots and codonopsis pilosula are selected and combined, so that efficacies of all medicines generate the synergistic effect. Wind is dispelled and dampness is eliminated; the liver and the kidney are tonified; meridians are warmed and activated; cold is eliminated and pains are relieved; neutralization is achieved, and blood stasis is removed; and the body resistance is strengthened, and pathogenic factors are eliminated. Yang is tonified and bones are boosted; stasis is eliminated and inflammation is prevented; and inflammatory invasion is prevented and peripheral nerve blood circulation is improved by the aid of various substance elements contained in natural medicines. According to observation of 200 clinical cases (150 cases of the Chinese herb preparation for treating rheumatism and heumatism in an experimental group and 50 cases of large activating pills in a comparison group), the preparation is strict in treatment rule, comprehensive in treatment, reasonable in formula, safe, reliable, exact in curative effect (the total effective rate is 91.85%), free from side effects and ideal in effect.
The invention relates to a traditional-Chinese-medicine-ingredient-containing yeast fermentation material. The yeast fermentation material is prepared from, by weight, 0.01% to 5% of active yeast, 5% to 15% of traditional Chinese medicine powder, 0.5% to 10% of nutrient starch and 0.01% to 2% of urea. The traditional Chinese medicine powder is prepared from, by weight, 5 parts to 20 parts of dry selfheal powder, 1 part to 10 parts of dry lophatherum gracile powder, 5 parts to 35 parts of dry white mulberry root bark powder, 5 parts to 25 parts of dry lotus powder, 5 parts to 35 parts of dry ligusticum wallichii powder and 5 parts to 25 parts of dry peony powder. The active yeast is rhodotorula rubra or saccharomyces cerevisiae. The nutrient starch is a mixture of one or two or more kinds of rice flour, wheat flour or corn flour. The invention further discloses a preparing method of the yeast fermentation material and an application of the yeast fermentation material. According to the yeast fermentation material, the yeast and the traditional Chinese medicinal material effective ingredients are provided at the same time and synergistically interact with each other; free radicals can be powerfully removed through the yeast fermentation material, the activity of tyrosinase can be remarkably inhibited, and the skin can be effectively whitened.
Stage IV EGFR-mutant NSCLC patients with no known tumor non-synonymous TP53 genomic alteration who are currently receiving first line osimertinib treatment and have received at least 3 months, but no more than 6 months, of osimertinib with a best response of PR or SD. Patients may receive alisertib therapy until lack of clinical benefit or intolerable toxicity.
The purpose of this study will be to examine the effects of Oceanix supplementation on isometric mid-thigh pull force kinetics and salivary immunoglobulin A (indice of immune function) following a one-week intense resistance training protocol. The study will be carried out in a randomized, double-blind, placebo-controlled, parallel manner. Subjects will be stratified into quartiles based on peak force achieved in the isometric mid-thigh pull assessment during screen and prior to baseline testing. Subjects from each quartile will be randomly divided by into treatment and or placebo conditions. Supplement conditions will be provided in visually identical capsules and containers. Supplement compliance will be determined via supplement logs and collection of supplement containers on day 21. Subjects will be instructed to refrain from consuming other nutritional supplements for the duration of the study.

Following randomization, subjects will be baseline tested on isometric mid-thigh pull and salivary immunoglobulin A. Following baseline testing, subject will be given their respective supplement conditions and will be instructed to consume one serving (25mg) a day for 21 consecutive days. For days 1 through 14 subjects will be instructed to consume their condition with their first meal of the day, and they will asked to refrain from resistance training during this time frame. Subjects will undergo a five day intense resistance training protocol will on day 15 to day 19, and they will be instructed to consume their condition approximately 30 minutes prior to the training session. Subjects will complete follow-up testing in a manner identical to baseline on day 20 and 21 (24- and 48-hours post completion of the training protocol) consuming their condition approximately 30 minutes prior to their arrival at the laboratory.

The five day resistance training protocol will consist of two lower-, two upper-, and one full-body workout. Exercise sets performed on the first four days of the protocol will be targeted will repetition maximum loads such that sets will be perform to or near muscular failure. On the fifth day of the protocol, subjects will perform sets of bodyweight rear foot elevated split squats to failure for a total of 10 sets (5 sets with each leg in an alternating fashion). Subjects will be instructed to maintain the cadence set on an audible metronome, which will be set at one second downward and one second upward. Failure for these sets will be defined as 1) volitional muscle failure or 2) failure to complete two consecutive repetitions at the prescribed metronome cadence. Subjects will rest for one minute between sets. Prior to all training sessions, subjects will perform a dynamic warm-up, and following all training sessions, subjects will complete a cool down with static stretching of the targeted muscle groups with the session. All warm-up, resistance training, and cool down sessions will be supervised by trained research personnel. All training sessions will be separated by at least 24-hours.
The invention discloses a noni homogeneous polysaccharide extraction and separation method and application, and relates to the field of polysaccharide extraction and separation and application. The invention aims to solve the technical problems that the existing extraction method of the noni polysaccharide has easily damaged components, long time consumption, low extraction rate and undefined pharmacological action of the noni polysaccharide. The method comprises the following steps: preparing noni coarse powder; flash extraction, concentration, alcohol precipitation, concentration and drying to obtain crude noni polysaccharide; deproteinizing and decoloring; eluting with DEAE-52 fiber column, and performing Sephadex G-75 gel column chromatography to obtain five kinds of noni uniform polysaccharides. The invention improves and optimizes the noni polysaccharide extraction method, can reserve the effective components of the plants to the maximum extent by utilizing the flash extraction method, obviously shortens the extraction time and greatly improves the extraction efficiency. The noni homogeneous polysaccharide has the proved inhibiting effect on human liver cancer cell HepG 2. The noni homogeneous polysaccharide extracted by the invention is used as a bioactive component for inhibiting human liver cancer cells and is applied to preparing antitumor drugs.
The present method is related to a molecular press dehydration method of vegetative tissues using water-soluble polymers in solid-phase as dehydrating agents. The molecular press dehydration method of the present invention is characterized by that dehydration is done by induction of cytorrhysis to vegetative tissues mixed with water-soluble polymers such as PEG, gum arabic, arabinogalactan, egg albumin, milk protein, soybean protein, etc. in its solid-phase. Compared to the conventional dehydration methods, the present method enables to obtain much greater dehydration effects in the amount and the rate, even though a very small amount of polymer substance is used; and the method enables to obtain excellent quality of dehydrated tissues as well as dehydrated exudates; and is environmentally friendly under favor of reduced energy consumption. The dehydrated vegetative tissues are excellent in their storage stability, and flavor and texture after rehydration, and dehydrated exudates are excellent in the concentrated useful components, flavor, and preservation quality. Therefore, the dehydrated vegetative tissues and exudates obtained by using the dehydration method of the present invention may be usefully applied to various fields such as foods and beverages, feeds, cosmetics, medicines, flavorings, agricultural chemicals, coloring agents, etc. according to the characteristics of plants.
This disclosure provides compounds having Bcl inhibitory activity. The acylaminophosphonate compounds may include a P-phenylaminophosphonate moiety N-acylated with an aroyl or heteroaroyl group. One of the heteroatoms attached to phosphorus may be a carbon atom that is cyclic attached to an adjacent phenyl ring attached to phosphorus to provide a heterocyclic ring with the phosphorus atom via which they are attached. By introducing such a ring constraint between two phosphorus substituents of the core linking module, an advantageous binding conformation can be promoted in the compound. The selected compounds promote apoptosis in senescent cells and may be developed for use in the treatment of senescence-associated conditions, such as osteoarthritis, ocular diseases, pulmonary diseases, and atherosclerosis. The selected compounds promote apoptosis in cancer cells and may be developed as chemotherapeutic agents.
There has been a major increase in Type 2 diabetes and obesity in many countries, and this will lead to a global public health crisis, which not only impacts on the quality of life of individuals well but also places a substantial burden on healthcare systems and economies. Obesity is linked to not only to type 2 diabetes but also cardiovascular diseases, musculoskeletal disorders, and certain cancers, also resulting in increased medical costs and diminished quality of life. A number of studies have linked changes in gut in obesity development. Dysbiosis, a deleterious change in gut microbiota composition, leads to altered intestinal permeability, associated with obesity and Type 2 diabetes. Many factors affect the homeostasis of gut microbiota, including diet, genetics, circadian rhythms, medication, probiotics, and antibiotics. In addition, bariatric surgery induces changes in gut microbiota that contributes to the metabolic benefits observed post-surgery. Current obesity management strategies encompass dietary interventions, exercise, pharmacotherapy, and bariatric surgery, with emerging treatments including microbiota-altering approaches showing promising efficacy. While pharmacotherapy has demonstrated significant advancements in recent years, bariatric surgery remains one of the most effective treatments for sustainable weight loss. However, access to this is generally limited to those living with severe obesity. This underscores the need for non-surgical interventions, particularly for adolescents and mildly obese patients. In this comprehensive review, we assess longitudinal alterations in gut microbiota composition and functionality resulting from the two currently most effective anti-obesity treatments: pharmacotherapy and bariatric surgery. Additionally, we highlight the functions of gut microbiota, focusing on specific bacteria, their metabolites, and strategies for modulating gut microbiota to prevent and treat obesity. This review aims to provide insights into the evolving landscape of obesity management and the potential of microbiota-based approaches in addressing this pressing global health challenge.
The prevalence of autism spectrum disorders (ASD) has been steadily increasing, and growing evidence suggests a link between high-fat diet (HFD), obesity, and ASD; however, the mechanism underlying this association remains elusive. Herein, BTBR T + tf/J (BTBR) inbred mice (a mouse ASD model) and C57Bl/6J (C57) mice were fed an HFD and normal diet (ND) for 8 weeks (groups: C57 + ND, C57 + HFD, BTBR + ND, and BTBR + HFD). Subsequently, mice underwent behavioral assessments, followed by intestinal tissues harvesting to detect expression of intestinal barrier proteins and inflammatory factors and immune cell numbers, and a correlation analysis. HFD-fed BTBR mice developed obesity, elevated blood sugar, significantly aggravated anxiety-like behaviors, impaired intestinal barrier function, intestinal inflammation with elevated CD4+IL17+ T (Th17) cells and reduced CD4+Foxp3+ T (Treg) cells, exhibiting reduced expression of proteins related to AMPK regulatory pathway (AMPK, p-AMPK, SIRT1). Correlation analysis revealed that the degree of behavioral anxiety, the degree of intestinal barrier damage, the severity of intestinal inflammation, and the degree of immune cell imbalance positively correlated with each other. Accordingly, HFD-induced obesity may cause intestinal Th17/Treg imbalance via the AMPK-SIRT1 pathway, leading to an inflammatory environment in the intestine, impairing intestinal barrier function, and ultimately aggravating anxiety-like behaviors in mice.