anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: In this study, we aimed to establish nomograms to predict the microvascular invasion (MVI) and early recurrence in patients with small hepatocellular carcinoma (SHCC), thereby guiding individualized treatment strategies for prognosis improvement.
METHODS: This study retrospectively analyzed 326 SHCC patients who underwent radical resection at Wuhan Union Hospital between April 2017 and January 2022. They were randomly divided into a training set and a validation set at a 7:3 ratio. The preoperative nomogram for MVI was constructed based on univariate and multivariate logistic regression analysis, and the prognostic nomogram for early recurrence was constructed based on univariate and multivariate Cox regression analysis. We used the receiver operating characteristic (ROC) curves, area under the curves (AUCs), and calibration curves to estimate the predictive accuracy and discriminability of nomograms. Decision curve analysis (DCA) and Kaplan-Meier survival curves were employed to further confirm the clinical effectiveness of nomograms.
RESULTS: The AUCs of the preoperative nomogram for MVI on the training set and validation set were 0.749 (95%CI: 0.684-0.813) and 0.856 (95%CI: 0.805-0.906), respectively. For the prognostic nomogram, the AUCs of 1-year and 2-year RFS respectively reached 0.839 (95%CI: 0.775-0.903) and 0.856 (95%CI: 0.806-0.905) in the training set, and 0.808 (95%CI: 0.719-0.896) and 0.874 (95%CI: 0.804-0.943) in the validation set. Subsequent calibration curves, DCA analysis and Kaplan-Meier survival curves demonstrated the high accuracy and efficacy of the nomograms for clinical application.
CONCLUSIONS: The nomograms we constructed could effectively predict MVI and early recurrence in SHCC patients, providing a basis for clinical decision-making.
In order to automate some aspects of software development, an application catalogue is provided. The application catalog is associated with an application (e.g., a medical device) and includes a plurality of parameters that each define a desired state of the software application when the software application is deployed). These parameters may include service parameters, application parameters, environmental parameters, feature parameters, API parameters, and infrastructure parameters. Before a software application is deployed to an environment, the states of the parameters with respect to the environment are determined and compared to the states of the parameters of the application catalog. The system then automatically takes the necessary steps to correct the states of any parameters of the environment to match those of application catalog. These steps may include installing services, enabling features, configuring infrastructure or environmental parameters, and allocating processing or storage resources to a virtual machine.
Blood replenishing liquor is specially effective nutritious liquor, can increase human body red blood cells and blood cells and recover blood function, is developed by modern Chinese traditional and western medicine combination theory and is suitable for people who are in poor health, have anemia and purpura, are prone to bleed and are ill constantly to drink. In order to solve the technical problem, the technical scheme is that a formula uses traditional Chinese medicine which can replenish heart and lung, replenish Qi and blood, aid digestion and increase red blood cells and blood cells and white granulated sugar based on the formula theory according to etiology and pathology of change of human body red blood cells, blood cells and blood functions. The formula is specifically composed of 13 kinds of traditional Chinese medicine of liquor, ginseng, hairy asiabell root, red-rooted salvia root, white atractylodes rhizome, lucid ganoderma, caulis spatholobi, angelica sinensis, polygonum multiflorum, madder, poria cocos and tomato and white granulated sugar. In a production process, the Chinese traditional liquor is smashed with traditional Chinese medicine which can replenish heart and lung, replenish Qi and blood, aid digestion and increase red blood cells and blood cells, and bottled edible nutritious liquor can be manufactured through the modern liquor production technology. Habits of Chinese liquor culture are preserved. Furthermore, the name of the blood replenishing liquor presents combination of etiology and pathology of change of human body red blood cells, blood cells and blood functions and clinical effects and technical features of Chinese traditional and western medicine combination theory and modern mechanical liquor manufacture.
Patients will start CPAP treatment with an auto-adjusting CPAP device with pressure levels between 4 and 12 cmH2O. After 7 nights of titration, the optimal pressure will be determined by analyzing the median of the nightly pressure that included 95% of the periods (percentile 95). CPAP treatment will be continued with this fixed optimal pressure.
The invention discloses blood sugar reducing traditional Chinese medicinal herb which is mainly prepared from the following raw materials: Ligusticum wallichii, rhizoma atractylodis and papaya milk powder. In the formula, rhizoma atractylodis has the function of drying damp and strengthening spleen and tonifying qi and yin, Ligusticum wallichii has the function of invigorating the circulation of blood and promoting the circulation of qi as well as dispelling wind and relieving pain, and papaya milk powder has the function of pleiotropic immunomodulatory effect, enhancing the health of diabetics, accelerating metabolism and improving the glucose metabolism of the organism. Medicines are combined in use to achieve the effects of clearing heat, invigorating the circulation of blood, invigorating spleen and supplementing qi, enriching yin and nourishing kidney, inducing diuresis with bland drug and reducing the blood sugar. In addition, as Ligusticum wallichii and rhizoma atractylodis are traditional Chinese medicines which are in homology of medicine and food, and papaya milk powder is an extract of papaya, so that the traditional Chinese medicinal herb is very safe to take, free from any acute and subacute or chronic hazard to a human body and suitable for long-term use. The traditional Chinese medicinal herb provided by the invention is scientific and reasonable in formula, exact in blood reducing effect, safe and effective. The product is prepared as an oral solid preparation which is stable in quality and convenient to carry and take, and is suitable for long-term use by diabetics.
Adhesive capsulitis, also known as frozen shoulder, is an inflammatory condition characterized by shoulder stiffness, pain, and significant loss of passive range of motion. Adhesive capsulitis has a prevalence of approximately 2% to 5% in the general population, with a mean onset of age of 55.

A randomized clinical trial will be conducted at Ibne Sina Hospital, Multan . Non probability convenience sampling technique will be applied on 50 patients who will be allocated through computerized randomization into group A \& group B to collect data. Group A will be given spencer technique and group B will be given reverse distraction technique along with baselines. The study will be completed within the time duration of ten months. Primary Outcome measures of the research will be pain, range of motion, function, muscle strength, disability and quality of life will be measured pre and post intervention. The whole treatment protocols will be given for four weeks. Data will be analyzed using SPSS software version 25. After assessing normality of data by Shapiro-wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.
Patients will receive a comprehensive assessment at baseline, year 1 and year 2. In the interim between these time points patients will be managed according to 'usual care' procedures.
The novel positively charged pro-drugs of retinoids and retinoid-like compounds in the general formula (31) 'Structure 31' were designed and synthesized. The compounds of the general formula (31) 'Structure 31' indicated above can be prepared from retinoic acids and related compounds, by reaction with suitable alcohols, thiols, or amines and coupling reagents, such as N, N'-Dicyclohexylcarbodiimide, N,N'-Diisopropylcarbodiimide, O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, Benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate, et al. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs in water, but also bonds to the negative charge on the phosphate head group of membranes. This bonding will disturb the membrane a little bit and may make some room for the lipophilic portion of the prodrug. When the molecules of membrane move, the membrane may 'crack' a little bit due to the bonding of the prodrug. This will let the prodrug insert into the membrane. At pH 7.4, only about 99% of amino group is protonated. When the amino group is not protonated, the bonding between the amino group of the prodrug and the phosphate head group of membrane will disassociate, and the prodrug will enter the membrane completely. When the amino group of the prodrug flips to the other side of the membrane and thus become protonated, then the prodrug is pulled into the cytosol, a semi-liquid concentrated aqueous solution or suspension. The results suggest that the pro-drugs diffuse through human skin -350 times faster than do retinoids and retinoid-like compounds. In plasma, more than 90% of these pro-drugs can change back to the parent drugs in a few minutes. The prodrugs can be used medicinally in treating any retinoids and retinoid-like compounds-treatable conditions in humans or animals. The prodrugs can be administered transdermally for any kind of medical treatments and avoid most of the side effects of retinoids and retinoid-like compounds. Controlled transdermal administration systems of the prodrug enables retinoids and retinoid-like compounds to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of retinoids and retinoid-like compounds. Another great benefit of transdermal administration of these pro-drugs is that administering medication, especially to children, will be much easier.
The present invention is technological process of producing bear bile tonic wine. Fresh bear bile and water in the same amount are mixed and vacuum deodorized in a tank with steam jacket at a temp. not over 60 deg.C. After cooling and condensation for 8-12 hr, bear bile is taken out. In a extractor, acunthopanax senticosus is reflux extracted with 7 times of 75% alcohol at 70-75 deg.C and concentrated into extract. Liquor, deodorized bear bile, the said extract, glycerine and monose syrup are blended to obtain the bear bile tonic wine.
Data about the impacts of hemodialysis on antioxidant status and markers of oxidative stress are controversial, probably due to the use of different methodological approaches. The aim of this study was to assess the changes in the oxidative damage markers and antioxidant enzymes, and the serum antioxidant capacity by using in vitro model systems of free radical generation before and after one hemodialysis session. Blood samples were collected from 40 patients with kidney failure before and after hemodialysis. In pre- and post-hemodialysis serum samples, concentrations of biomarkers of oxidative damage and the activities of antioxidant enzymes were measured, as well as the in vitro antioxidant potential. The high concentrations of oxidative stress markers in serum of kidney failure patients were decreased after one hemodialysis session. In pre-hemodialysis, low activities of antioxidant enzymes were observed, including paraoxonase-1, however paraoxonase-1 activity was partially recovered after hemodialysis. Crocin bleaching and radical scavenging assays showed that serum antioxidant potential was decreased after hemodialysis. Although one hemodialysis session increased paraoxonase-1 activity and decreased oxidative stress markers, it caused a decrease in the serum antioxidant potential. Future research is needed to prospect strategies to mitigate the impacts of oxidative stress in the scenario of hemodialysis repetitions.
INTRODUCTION: Proprioception can be impaired in people with neck pain. The cervical joint position sense test, which measures joint position error (JPE), is the most common test used to assess neck proprioception. The aim of this systematic review was to assess the measurement properties of this test for the assessment of people with and without neck pain.
METHODS: This systematic review was registered prospectively on Prospero (CRD42020188715). It was designed using the COSMIN guidelines and reported in line with the PRISMA checklist. Two reviewers independently searched Medline, Embase, SportDiscus, and CINAHL Plus databases from inception to the 24th July 2022 with an update of the search conducted until 14th of October 2023. The COSMIN risk of bias checklist was used to assess the risk of bias in each study. The updated criteria for good measurement properties were used to rate individual studies and then the overall pooled results. The level of evidence was rated by two reviewers independently using a modified GRADE approach.
RESULTS: Fifteen studies were included in this review, 13 reporting absolute JPE and 2 reporting constant JPE. The measurement properties assessed were reliability, measurement error, and validity. The measurement of JPE showed sufficient reliability and validity, however, the level of evidence was low/very low for both measurement properties, apart from convergent validity of the constant JPE, which was high.
CONCLUSION: The measure of cervical JPE showed sufficient reliability and validity but with low/very low levels of evidence. Further studies are required to investigate the reliability and validity of this test as well as the responsiveness of the measure.
Improvements in methods for treating diseases and tumors with compositions of matter defining drug units, each of which includes an antibody, such as a monoclonal antibody produced outside of the body of a living being to be treated. Each unit contains a quantity of normally inactive nuclide capable of being rendered radioactive for treating a disease and a quantity of a second nuclide which may be normally inactive or radioactive, such as a radionuclide. The antibody is targeted to a specific antigen existing in the patient being treated. The drug units emit such radiation upon being activated within the body by radiation such as neutron radiation generated to detect the presence of a particular disease in a living being and to provide an indication of the location and extent of such disease. Once a concentration of disease cells is so located by analyzing signals derived from one or more detectors of radiation generated by a nuclide carried by antibodies to the disease site, and its extent or shape is determined by analysis of direct or reconstructed images of the interior of the body at the site, nuclide material carried to the detected site may be activated by properly controlling the location of a source of activating radiation, its direction and activation to effect treatment of the disease. Treatment radiation may include atomic disintegration of a small quantity of a nuclide, such as boron-10 by absorption of neutrons directed through the body, which disintegration results in the generation of high velocity particles or fragments capable of the localized destruction of diseased cells such as cancer cells.
The intervention group will first receive 5 times EMA per day for one week. The EMA will document participants smoking behaviors, smoking cues, smoking cravings, etc. The intervention group will receive 15-30 minutes of a nurse-led phone call, and 10-week instant messaging after completing the one-week EMA documentation.
Sham training will consist of 9 cognitive training sessions, each session lasting approximately 20 minutes completed on separate days over 3 weeks. Each session requires the participant to respond to 240 visual stimuli using a push or pull motion as quickly as possible.
The developmental language disorder control group will receive the conventional language rehabilitation sessions in 30 minute sessions twice a week, for 3 months. Conventional language therapy targets semantics, syntax, prosody, pragmatics, and phonology.
OBJECTIVE: Aim: To determine the current prevalence of postpartum infections and antimicrobial resistance and antimicrobial resistance of responsible pathogens in Ukraine.
PATIENTS AND METHODS: Materials and Methods: Multicenter prospective cohort study was conducted from January 2020 to December 2022 in fifteen hospitals from twelve regions of Ukraine. Definitions of healthcare- associated postpartum infection were adapted from the Centers for Disease Control and Prevention's National Healthcare Safety Network. Antibiotic susceptibility was done by the disc diffusion test as recommended by EUCAST.
RESULTS: Results: Among 21,968 women, 6,175 (28.1%) postpartum infections were observed. Of all postpartum infection cases, 83.1% were detected after hospital discharge. The postpartum infection rates were 17.3% after cesarean section and 10.8% after vaginal delivery. The most common postpartum infection types were endometritis (17.3%), followed by urinary tract Infection (3.5%), mastitis (3.4%), surgical site infection (excluding endometritis) (2.4%), and episiotomy site infection (1.5%). The predominant postpartum infection pathogens in Ukraine were: Escherichia coli (10.4%), Enterococcus spp. (9.6%), Staphylococcus aureus (6.7%), Pseudomonas aeruginosa (5.8%), Enterobacter spp. (5.8%). In our study pathogens of postpartum infection had differently levels of resistance to antibiotics.
CONCLUSION: Conclusions: Our results indicate that postpartum infections requiring medical attention are common in Ukraine and that most postpartum infections occur after hospital discharge, so that use of routine inpatient surveillance methods alone will lead to underestimation of postpartum infection rates. Optimizing the antibiotic prophylaxis may reduce the burden of postpartum infection, but prevention is the key element.
PURPOSE: Neoadjuvant chemotherapy (NAC) is increasingly used in breast cancer. Predictive modeling is useful in predicting pathologic complete response (pCR) to NAC. We test machine learning (ML) models to predict pCR in breast cancer and explore methods of handling missing data.
METHODS: Four hundred and ninety-nine patients with breast cancer treated with NAC in two centers in Singapore (National Cancer Centre Singapore [NCCS] and KK Hospital) between January 2014 and December 2017 were included. Eleven clinical features were used to train five different ML models. Listwise deletion and imputation were evaluated on handling missing data. Model performance was evaluated by AUC and calibration (Brier score). Feature importance from the best performing model in the external testing data set was calculated using Shapley additive explanations.
RESULTS: Seventy-two (24.6%), 18 (24.7%), and 31 (24.8%) patients attained pCR in NCCS training, NCCS testing, and KK Women's and Children's Hospital (KKH) testing data sets, respectively. The random forest (RF) base and imputed models have the highest AUCs in the KKH cohort of 0.794 (95% CI, 0.709 to 0.873) and 0.795 (95% CI, 0.706 to 0.871), respectively, and were the best calibrated with the lowest Brier score. No statistically significant difference was noted between AUCs of the base and imputed models in all data sets. The imputed model had a larger positive predictive value (PPV; 98.2% v 95.1%) and negative predictive value (NPV; 96.7% v 90.0%) than the base model in the KKH data set. Estrogen receptor intensity, human epidermal growth factor 2 intensity, and age at diagnosis were the three most important predictors.
CONCLUSION: ML, particularly RF, demonstrates reasonable accuracy in pCR prediction after NAC. Imputing missing fields in the data can improve the PPV and NPV of the pCR prediction model.
Grape-flavored wipes will be used with 2 drops of PCCA colorless grape flavoring. The grape-flavored wipes each contain a solution of 0.9% Sodium Chloride, purified water, and Benzalkonium chloride. PCCA artificial colorless grape flavoring will be used. The PCCA grape flavoring contains propylene glycol, ethyl alcohol, and artificial flavoring.
The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I), wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, -(CH2)q-, etc.;  R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of formula (II) (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.
PURPOSE: A method for manufacturing a nanocomposite for pH sensitive drug delivery is provided to easily and quickly penetrate the nanocomposite into a target cells. CONSTITUTION: A nanocomposite for pH sensitive drug delivery contains a polymer having a 2,3-dimethylmaleic acid induced to am amine group of polysaccharide. The polysaccharide is pullulan, cudlan, hyaluronic acid, pectin, chitosan, dextrin, heparin, or starch. A nanocomposite has a drug with pharmacological activity. The drug is a protein, peptide, or synthetic compound. A method for manufacturing the nanocomposite comprises: a step of dissolving polysaccharides in a solvent; a step of adding 2,3-dimethylmaleic acid to a solution in which polysaccharides are dissolved; and a step of dialyzing and freeze-drying the synthesized polymers.
NEW MATERIAL:The peptide of formula I (A is Ser or Tyr; B is Gly or Glu; X is Ala or Val; the steric configuration of amino acid residues is D, L or DL). EXAMPLE:H-Ser-Gln-Glu-Asp-Pro-Asn-Ala-Tyr-Ser-Gly-Glu-Leu-Phe-Asp-Ala-OH. USE:A synthetic intermediate of the peptide of formula II[Y is OH or NR<1>R<2> (R<1> and R<2> are H or alkyl)] having analgesic activity. Useful for the preparation of an antiserum acting specifically to the peptide of formula II, and for the detection and determination of prodynorphin. PROCESS:After protecting the amino groups and carboxyl groups having no participation in the reaction, the required peptide chains are bonded successively to the C-terminal according to the peptide synthesis process. The protecting groups are removed from the obtained ptotected peptide by conventional method to obtain the objective peptide of formula I .