anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Bupivacaine Hydrochloride (HCL) and Lidocaine. Fifty mL of 0.05% Marcaine and 30 mL of Lidocaine will be diluted in 100 mL of injectable saline used for hydro-dissection of the vesicovaginal space and along the track of the sling trocars during the placement of a suburethral sling.
We will present individuals with medically accurate information about a medical condition and measure people's perceptions of their own likelihood to having that medical condition. This will include an opportunity for people to pursue more information by directing them to a website that features more information about the condition. The initial information provision will vary slightly in presentation (method of eliciting symptoms will vary), and the rate at which individuals visit the subsequent medical website to receive more information will be recorded as a measure of information seeking behavior. Rates will be compared across symptom elicitation conditions to determine which formats are most effective at encouraging information seeking about health issues. No personally identifying information will be collected, and all results will be reported in aggregate. Critically, no deception will be used: Participants will only be provided with information that is as accurate as possible (given existing knowledge in the health/medical fields).
OBJECTIVE: This study aimed to investigate the function and mechanism of lncRNA NORAD in Sevoflurane (Sev) protection against myocardial hypoxia-reoxygenation (H/R).
METHODS: Preprocess rat cardiomyocytes H9c2 cells with Sev at concentrations of 0.5%, 1.0%, and 1.5%, and subjected them to H/R treatment. qRT-PCR was used to detect levels of NORAD and miR-144-3p. Measure concentrations of the inflammatory cytokines IL-6, TNF-α, and IL-10, as well as cardiac injury markers cTnI, CK-MB, and LDH using ELISA. Assess cell proliferation and apoptosis using CCK-8 and flow cytometry. Perform dual-luciferase reporter assay and RIP assay to validate the targeting relationship between NORAD and miR-144-3p.
RESULTS: H/R induced inhibition of cell proliferation, increase in apoptosis, and production of IL-6, TNF-α, CK-MB, LDH, and cTnI were significantly attenuated by Sev. As hypoxic treatment time lengthened, the NORAD levels in myocardial cells showed an increase, with Sev pretreatment being able to suppress the NORAD levels elevation. The overexpression of NORAD notably weakened the cardioprotective effect of Sev. NORAD targetedly binds to miR-144-3p and negatively regulates miR-144-3p. Increased miR-144-3p levels inhibited the antagonistic effect of NORAD on the cardioprotective effects of Sev.
CONCLUSION: The current study confirmed that sevoflurane attenuated H/R-induced cardiomyocyte injury via the NORAD/miR-144-3p axis.
The present invention includes peptides that bind to and inhibit the function of the integrin receptor, αVβ3. It also includes peptides that bind the integrin receptor αVβ5. The inventive peptides are between nine to about thirty amino acids in length. The peptides include an amino acid sequence comprising the binding domain Thr-Cys-X1-X2-Arg-Ala-Asp-Cys-X3 and an amino acid sequence comprising the binding domain Arg-Cys-Gly-Gly-Asp-Ser-X4-Cys-Tyr. These non-RGD peptides display surprisingly potent antagnonist activity despite the lack of the consensus binding sequence Arg-Gly-Asp, and present opportunities for selective targeting to the αVβ3 receptor. Pharmaceutical compositions and methods of use are also disclosed. The therapeutic uses for the inventive peptides include treating diseases involving αVβ3 receptors such as cancer, osteoporosis, restenosis, and angiogenic-based diseases.
658,144. Artificial teeth. EGGER, L. June 7, 1949, Nos. 15120, 15121 and 15122. Convention dates, July 6, 1946, July 18, 1946, Feb. 4, 1947. [Class 81(ii)] A composite tooth is made in crown and base sections, one having a conical socket and the other a conical spigot of slightly' smaller angle, so that the crown may rock on the base, and an intermediate cushion of a resilient substance. The tooth may be of porcelain with a synthetic rubber cushion or may be partly or wholly of synthetic plastic material. In one form the crown 11, Fig. 1, is formed with a conical socket 16, the apex of which engages the apex of a conical member 10. The space between the two contains a resilient cushion 12 which is preferably brought out to form a shoulder 40 to provide greater bearing surface. All the parts may be cemented or otherwise secured together. It is also proposed to form the base member as part of the palate of the denture, (see Fig. 4, not shown), and in a further modification the socket is formed in the base part and the spigot in the crown, (see Fig. 5, not shown), this arrangement giving the possibility of increased movement.
GELNIQUE is for topical application only and should not be ingested.

GELNIQUE should not be applied to recently shaved skin surfaces. Patients should wash hands immediately after product application. Application sites should not be subject to showering or water immersion for 1 hour after product application. Application sites should be covered with clothing if close skin-to-skin contact at the application site is anticipated.

Alcohol based gels are flammable. Avoid open fire or smoking until the gel has dried.
Phenylephrine, a potent sympathomimetic, induces mydriasis via iris dilator muscle contraction. Intracameral (IC) phenylephrine has been successfully used in cataract surgery for initial mydriasis, maintaining mydriasis, and management of intraoperative floppy-iris syndrome. Serious systemic adverse events (mainly cardiovascular) have been described with topical phenylephrine drops, but we found very little evidence of such adverse events associated with IC phenylephrine use. However, we suspect under-reporting of such adverse events, as they may instead be ascribed to anxiety, positioning, anesthesia, etc. Optimal dosage/concentrations for IC phenylephrine use in different purposes have not been fully studied. In the absence of robust evidence, we suggest that lower but effective IC phenylephrine concentrations are used: a lower concentration (0.31%), in conjunction with an anticholinergic and lidocaine, may be used for initial mydriasis. For management of intraoperative floppy-iris syndrome, 0.31% may be effective, though a higher concentration (1% to 1.25%) may be required.
PURPOSE: To summarize the causes of retinal arterial microaneurysm combined with branch retinal artery occlusion.
METHODS: The case reports of retinal arterial microaneurysm combined with branch retinal artery occlusion were searched in PubMed, Web of Science, and CNKI databases before May 1, 2024. A total of nine participants from nine case reports were included to analyze factors leading to complications.
RESULTS: The reasons for this complication are as follows: complications during photocoagulation therapy. Intraretinal hemorrhage and exudation result in compression of adjacent or distal arteries, resulting in branch retinal artery occlusion. Embolus dislodgement or intraarterial embolus formation can block the artery, damage the wall, and provide conditions for the development of retinal arterial microaneurysm. In addition, it is necessary to be alert to the optic disk macroaneurysm, if hemorrhage or embolus formation in the macroaneurysm will affect the blood supply of the downstream artery, affecting a large range of the retina.
CONCLUSION: Based on the review of case reports, we found that retinal arterial microaneurysm and branch retinal artery occlusion can cause each other. Acute vision loss can result when a complication occurs. In addition, retinal vascular diseases can reflect the whole body, suggesting that ophthalmologists need to pay attention not only to the patient's fundus but also to the patient's systemic diseases.
Deep pressure were applied along origin and insertion of Piriformis and hamstring muscle combined with active movement of patient for 5 -15 time as per required (depend upon thickness of scar) per session, 10 sec rest b/w pressure. This technique given 5 time per session. Conventional treatment include Hot Pack for 5mins, AROM exercises ,Home plans include stretching exercise of glutes,hamstring and calf (5-7 reps x 10 sec hold, each).
1,219,785. Veterinary antibiotic compositions. ELI LILLY & CO. 20 March, 1968 [20 March, 1967], No. 13452/68. Heading A5B. Compositions for the control of mycoplasmic infections in poultry comprise an antibiotic* effective against mycoplasma and a polyoxyethylene ether of the formula: wherein n is a number between 10 and 35 and R is cholesteryl or C 12-20  alkyl or alkenyl; the weight ratio of antibiotic to polyoxyethylene ether being between 1:25 and 30:1. They may be in the form of feedstuffs or drinking preparations and premixes for addition to feed and drinking water. * Specified antibiotics are aureomycin, bottromycin, tetracycline, erythromycin, spiromycin, lincomycin and tylosin.
INTRODUCTION: Poor sleep quality has been associated with inflammatory bowel disease (IBD) activity, although studies incorporating actigraphy suggest that the perception of sleep differs rather than objective difference in sleep quality. Short sleep duration has been associated with increased pro-inflammatory cytokines that have been implicated in the pathogenesis of IBD.
METHODS: An observational study incorporated home-based polysomnography that was conducted within twelve weeks of an objective assessment of IBD activity such as calprotectin, colonoscopy, or MRI. Participants completed a survey on subjective measures of sleep quality, clinical IBD activity, depression, and anxiety. Polysomnography results were normalized by standardized results for a healthy population matched by gender and age.
RESULTS: Twenty participants were included in the final analysis. Those with objective evidence of active IBD had shorter stage 2 sleep duration, leading to shorter NREM sleep and total sleep time. Sleep latency was also longer in those with active IBD, leading to worse sleep efficiency-despite no difference in time available for sleep between the two groups. These changes persisted after normalization of polysomnography results by health population age and gender matched norms. Depression scores correlated with sleep latency and stage 2 sleep duration and were associated with objectively active IBD.
CONCLUSIONS: Objectively confirmed active IBD was associated with shorter sleep duration. Observed sleep changes may, in part, relate to coexistent depression. Further research should consider the utility of changes in sleep duration and quality as a means of longitudinally assessing objective IBD activity.
Iatrogenic arterial injuries may occur during neurosurgical procedures. Particularly, the vertebral artery may be injured in a high-level cervical spinal fusion case, either during the initial exposure or when placing screws.1- 3 If such an injury occurs, obtaining hemostatic control and repairing the laceration are of paramount importance.4, 5 In this technical video, we describe the case of a patient who was undergoing a posterior C1-C2 cervical fusion when the right vertebral artery was injured due to variant anatomy. Using sutures to repair the injury was unsuccessful. Thus, we employed a technique known as crimping, which involves the use of vascular clips to pinch off the site of the tear. This technique is an improvement over existing methods given how quickly and easily it can be performed. In our technical video, we explain how to perform the crimping technique and discuss indications for its use. The patient consented to the procedure.
Huntington's disease (HD) is a dominantly inherited disorder. It is uniformly progressive and there is no known effective treatment or cure. The pathogenesis is largely unknown; however, recent studies implicate caspase activation, glutamate excitotoxicity, and free radical toxicity as possible causes of HD. Pharmacological agents that block these pathways may be therapeutic in HD. Minocycline is an antibiotic that also inhibits caspase-1 and caspase-3 expression, and inducible nitric oxide synthetase activity, which are factors that may play an important role in the mechanisms of neuropathology in HD.

Two dosages of minocycline or placebo will be given to ambulatory patients with HD over an 8-week period and the tolerability will be compared. Additional measures of safety and the change in motor, behavior, cognitive, and function features will be examined.
BACKGROUND: Studies have reported positive associations between drug-induced movement disorders (DIMDs) and symptoms of psychosis in patients with schizophrenia. However, it is not clear which subtypes of symptoms are related to each other, and whether one symptom precedes another. The current report assessed both concurrent and temporal associations between DIMDs and symptoms of psychosis in a community-based sample of homeless individuals.
METHODS: Participants were recruited in Vancouver, Canada. Severity of DIMDs and psychosis was rated annually, allowing for the analysis of concurrent associations between DIMDs and Positive and Negative Syndrome Scale (PANSS) five factors. A brief version of the PANSS was rated monthly using five psychotic symptoms, allowing for the analysis of their temporal associations with DIMDs. Mixed-effects linear and logistic regression models were used to assess the associations.
RESULTS: 401 participants were included, mean age of 40.7 years (SD = 11.2) and 77.4% male. DIMDs and symptoms of psychosis were differentially associated with each other, in which the presence of parkinsonism was associated with greater negative symptoms, dyskinesia with disorganized symptoms, and akathisia with excited symptoms. The presence of DIMDs of any type was not associated with depressive symptoms. Regarding temporal associations, preceding delusions and unusual thought content were associated with parkinsonism, whereas dyskinesia was associated with subsequent conceptual disorganization.
CONCLUSIONS: The current study found significant associations between DIMDs and symptoms of psychosis in individuals living in precarious housing or homelessness. Moreover, there were temporal associations between parkinsonism and psychotic symptoms (delusions or unusual thought content), and the presence of dyskinesia was temporally associated with higher odds of clinically relevant conceptual disorganization.
PURPOSE:To obtain a therapeutic agent for dysuria such as pollakiuria, urgency or incontinence of urine related to diseases such as neuropathic pollakiuria, neurogenic bladder, nocturnal enuresis, unstable bladder, bladder contraction, chronic cystitis or chronic prostatis. CONSTITUTION:A therapeutic agent for pollakiuria containing a compound expressed by the formula (R<1> to R<3> are lower alkyl) or its salt, e.g. (f)-(2R*, 4R*)-4-dimethylamino-2-phenyl-2-(2pyridyl) valeramide as an active ingredient. The aforementioned compound has anticholine activity and is capable of exhibiting inhibitory effects in a bladder contraction model. Thereby, this compound is useful as the above-mentioned therapeutic agent and usefulness for treating asthma, angina pectoris, etc., is further expected. The aforementioned therapeutic agent for dysuria can orally or parenterally be administered in the form of a normally used medicinal pharmaceutical and the above-mentioned active ingredient can normally be administered in a unit dose of 0.1-500 mg/ individual per day in 1-4 divided portions.
Background and Objectives: The conventional posterior approach in the lateral decubitus position is widely used for femoral neck fractures in femoral hemiarthroplasty. Postoperative dislocation is the major problem with this approach. The conjoined tendon-preserving posterior (CPP) approach is a less invasive surgical approach than the conventional posterior approach to the hip, maintains posterior stability, and preserves short external rotators and joint capsules. However, the mention was required to avoid muscle damage and whether muscle damage affects postoperative dislocation or not. The current study aimed to evaluate the clinical results of the CPP approach in hemiarthroplasty for femoral neck fractures and identify muscle damage risk factors. Materials and Methods: This study was a retrospective cohort study and included 170 hips in 168 patients. The mean age at the operation was 81.2 years. The preservation rate of the internal obturator muscle and gemellus inferior muscle and factors related to intraoperative short rotator muscle injury were investigated retrospectively. The postoperative complications and the relation between muscle damage and postoperative dislocation were investigated. Results: In the four hips (2.3%) with the obturator internus muscle damage, thirty-eight hips (22.4%) with gemellus inferior muscle damage were detected; in the muscle-damaged cases, the high body mass index (BMI) was significantly higher. The complication occurred in four hips (2.3%), including postoperative posterior dislocation in one hip without muscle damage (0.6%). Postoperative infection occurred in one hip (0.6%), and peroneal or sciatic nerve paralysis was suspected in two hips (1.1%). Conclusions: Compared to the conventional posterior approach in previous reports, the CPP approach reduces postoperative dislocation. A higher BMI is a risk factor for muscle damage, and the gemellus inferior muscle damage has no effect on postoperative dislocation. The CPP approach for BHA appeared to be an effective treatment method.
A system and a method for managing a clinical trial of patients. The method inlcudes obtaining consents of the patients undergoing the clinical trial and storing consent data of the patients. Consent data of the patients is validated before progressing onto any stage of the clinical trial. Data associated with at least one clinical trial site is collected for performing the clinical trial. The patients are randomly grouped into two or more groups for performing one or more of a single blinded study and a double blinded study during the clinical trial. Clinical data and non-clinical data of the patients is collected during the clinical trial. Timelines, progress, compliance, and data associated with different stages of the clinical trial are managed.
Recombinant cells are disclosed. The cells comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element. The cells additionally comprise a gene that encodes a protein which can be targeted for selective elimination. Methods of treating an individual suspected of suffering from an organ insufficiency condition are disclosed. The methods comprise introducing into such an individual, a plurality of recombinant cells that comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element and that also comprise a gene that encodes a protein which can be targeted for selective elimination. Implantable devices are disclosed. The implantable devices comprise a plurality of recombinant cells that comprise a recombinant expression cassette which contains a nucleotide sequence that encodes a condition sensitive transforming protein operable linked to an activatable regulatory element and that also comprise a gene that encodes a protein which can be targeted for selective elimination. Gene therapy compositions and methods are disclosed for preparing and using recombinant cells to deliver therapeutic proteins to individuals.
A bath water comprising activated concentrated solution of nature minerals, activated concentrated seawater, shell powder, chelating agent, pH-adjusting agent and pure water. Said activated concentrated solution of nature minerals and said activated concentrated seawater are mixed in the ratio of 1:1-50. Based on the total amount of said mixture above, the amount of shell powder is 0-30%. Said bath water has pH of 5.5-7.5 and the specific gravity of 1.1-1.8. Said activated concentrated solution of nature minerals is prepared by dissolving the powder of ores in the dissolving solution. Said powder of ores includes those of zinc ore, mica, vermiculite and magnesium ore.
Patients receive CPX-351 IV over 90 minutes on days 1, 3, and 5 of cycle 1 and IMGN632 IV on days 1 and 22 of cycle 1 in the absence of disease progression or unacceptable toxicity. Patients then receive fludarabine IV over 30 minutes QD on days 1-5 of cycle 2, cytarabine IV over 1-3 hours QD on days 1-5 of cycle 2, and IMGN632 IV on days 1 and 22 of cycle 2 in the absence of disease progression or unacceptable toxicity.
INTRODUCTION AND HYPOTHESIS: Transgender men and transmasculine individuals report a variety of lower urinary tract symptoms (LUTS), but little is known about LUTS in this population. One of the obstacles is the lack of validated questionnaires. This study was aimed at validating the International Consultation on Incontinence Questionnaire-Lower Urinary Tract Symptoms (ICIQ-LUTS), which measures filling, voiding, and incontinence symptoms, in transmasculine individuals.
METHODS: This is an observational validation study that included transmasculine individuals receiving care within a single tertiary care hospital system. Construct validity was assessed by comparing the ICIQ-LUTS with severity of LUTS as measured by the Urinary Distress Inventory-Short Form (UDI-6), and concurrent validity by the association between ICIQ-LUTS and the Patient Perception of Bladder Condition (PPBC). Discriminant validity was determined by comparing ICIQ-LUTS scores in those with and those without self-reported LUTS. Spearman correlation, t test, and Kruskal-Wallis test were used for data analysis.
RESULTS: A total of 131 respondents were included in the analysis. Only two individuals (1.5%) reported prior vaginectomy and/or phalloplasty. Concurrent validity was demonstrated by a significant association between ICIQ-LUTS subscales and PPBC (filling p < 0.001, voiding p < 0.001, incontinence p < 0.001). Construct validity was demonstrated by a significant correlation between ICIQ-LUTS and UDI-6 (filling ρ = 0.76, p < 0.001; voiding ρ = 0.48, p < 0.001; incontinence ρ = 0.61, p < 0.001). For discriminant validity, those with at least one self-reported LUTS had significantly higher (worse) ICIQ-LUTS subscale scores than those without self-reported LUTS.
CONCLUSIONS: The ICIQ-LUTS is valid for measurement of LUTS severity in transmasculine individuals. This will be an important tool to use in future research to learn more about LUTS in this population.
MMG-23-04-2019 is composed by sodium hyaluronate at concentration of 2% (20 mg/ml) with 1,4-Butanediol diglycidyl ether (BDDE) acting as a cross-linking agent, in aqueous solution at physiological pH. The filler of 1ml is administered once or twice depending on the individual necessity.