anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sepsis is still one of the most common causes of death of animals and humans. It is marked by an aberrant immune response to infection, resulting in extensive inflammation, organ dysfunction, and, in severe instances, organ failure. Recognizable symptoms and markers of sepsis encompass substantial elevations in body temperature, respiratory rate, hemoglobin levels, and alterations in immune cell counts, including neutrophils, monocytes, and basophils, along with increases in certain acute-phase proteins. In contrast to human medicine, veterinarians must take into account some species differences. This article provides a comprehensive overview of changes in the immune system during sepsis, placing particular emphasis on species variations and exploring potential future drugs and interventions. Hence, understanding the intricate balance of the immune responses during sepsis is crucial to develop effective treatments and interventions to improve the chances of recovery in animals suffering from this serious condition.
Chitin beads having a uniform fine particle diameter and comprising a microsporidian spore whose main cell wall material is chitin; chitosan beads having a uniform fine particle diameter and prepared by N-deacetylating the chitin; a process for preparing the beads; a carrier comprising the beads; and a process for preparing a microsporidian spore. A microsporidian spore is propagated in an insect or a culture cell to prepare chitin beads having a uniform fine particle diameter and containing chitin as the main cell wall material. The chitin as the cell wall material is N-deacetylated to prepare chitosan beads. When the insect is the larva of a domesticated silkworm, the microsporidian spore is orally or percutaneously inoculated in a concentration of 5 x 102 to 5 x 108/ml into the larva of a second-instar exuviated domesticated silkworm to effect propagation. The propagated microsporidian spore is taken out of the grown fifth-instar larva body and purified to prepare chitin beads having a uniform fine particle diameter and chitosan beads are prepared therefrom in the same manner as that described above. These beads are used as a carrier for immobilizing or encapsulating various materials such as antibiotics and microorganisms.
Patients prescribed palliative radiation therapy with moderate-severe cancer-related anxiety or depression will be prescribed 3 Ketamine Assisted Psychotherapy (KAP) sessions. At the time of enrollment, they will complete surveys to assess depression, anxiety, and existential distress. KAP will be preceded by a preparatory session during which the subjects will virtually meet their the KAP clinical team, discuss important stressors or concerns, and prepare for KAP. Each KAP session will last approximately 3 hours during which patients will receive an individualized dose of Ketalar intramuscularly, and after the ketamine experience subsides, the patient will discuss the experience with a psychotherapist trained in KAP. A virtual integration session will occur the day after each KAP session as it provides patients with an opportunity to work collaboratively with their assigned therapist in a manner that can help translate any insights from their preparation and KAP sessions into actionable goals. Depression, anxiety, and existential distress will be measured throughout the trial to assess the impact from KAP.
Disclosed is a cement for dental applications, which comprises a first preparation and a second preparation, wherein each of the first and second preparations comprises a polymerizable monomer (a) and a filler (b), wherein the first preparation and/or the second preparation further contains a photopolymerization initiator (c), and wherein at least one of the first and second preparations contains an oxidizing agent (f) which is a component of a redox polymerization initiator comprising the oxidizing agent (f) and a reducing agent (g) (the redox polymerization initiator is used as a chemical polymerization initiator (d)) and the other contains the reducing agent (g) which is the other component of the redox polymerization initiator. The photopolymerization initiator (c) comprises an a-diketone. The total content of the photopolymerization initiator (c) is 0.010 to 0.100 part by weight relative to the total amount (100 parts by weight) of the polymerizable monomer (a). The total content of the chemical polymerization initiator (d) is 0.001 t0 20 parts by weight relative to the total amount (100 parts by weight) of the polymerizable monomer (a). When the cement is photo-cured, the compression elasticity of a cured product is 100 to 400 MPa immediately after the photo-curing and becomes 500 MPa or more 24 hours after the photo-curing. The cement for dental applications can be used suitably for the bonding between a tooth structure and a crown prosthesis or the like in the field of dental care.
This study aims to find out if the combination of STAR particles with numbing gel can deliver anesthesia faster than applying the gel by itself. STAR particles are very small particles with microneedles on the surface that can increase and create small punctures in the skin. The small punctures should allow for the numbing gel to work more quickly and allow the area to become numb more quickly.

After pretreatment with STAR particles (applied to the right or left arm) and aloe gel (used as a control condition in the contralateral arm) a numbing gel will be applied. A Pin-Prick test will be performed to evaluate local anesthesia from the numbing gel; half the participants will be evaluated 10 minutes after application of the numbing gel and the other half will be assessed 20 minutes after the numbing gel is applied. The study team will also assess pain after needle insertion and measure how much water is being lost from the skin using a device called a Vapometer before and after the STAR particle and aloe gel applications. Participants will have follow-up calls 24 hours and 1 week after the visit to ask about any changes to the skin where the STAR particles were applied.
PURPOSE: A gene encoding novel ferritin with iron-binding activity is provided to express a large amount of ferritin in a host cell without side effect. CONSTITUTION: An iron-binding activity polypeptide has an amino acid sequence of sequence number 1 or 2. The polypeptide is derived from Perinereis aibuhitensis. Ferritin contains the polypeptide as a subunit. A nucleotide sequence encoding the polypeptide is denoted by sequence number 3 or 4. A pharmaceutical composition for preventing and treating iron deficiency contains the polypeptide. A composition for feed additive contains the polypeptide.
FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention relates to synthetic biologically active compounds of heterocyclic order. Invention is solved by synthesis of the group of novel chemical compounds: N-substituted derivatives of 5-hydroxyiminobarbituric (violuric) acid of the general formula (I)   where values of radicals X, R1 and R2 are given in the description text . Invention gives examples of synthesis of substances, yield value of products, data of elemental analysis and results of experiments of assay of their biological properties. New chemical synthesis of the present invention show antiviral, immunostimulating, antichlamydiosis, antituberculosis, antibacterial, antiaggregating, antiatherosclerotic, psychostimulating, psychodepressant, analgetic, hypoglycaemic, antiulcer, hepatoprotective and antioxidant activities. EFFECT: enhanced biological activity, expanded profile of biological effect as compared with prototype. 46 cl, 19 tbl, 3 ex
Levothyroxine (T4) is used to treat patients with hypothyroidism and may often result in lifelong therapy. Its physiologically active metabolite is tri-iodothyronine (T3). Levothyroxine is also endogenously produced in the body. Since small changes in levothyroxine administration (e.g. change in brand or formulation) can cause significant changes in serum thyroid stimulating hormone (TSH) concentrations, precise and accurate TSH control is critical to avoid potential adverse iatrogenic effects. Till date, the active pharmaceutical ingredient (API) for levothyroxine tablets marketed in India has been sourced from company 1. GSK India proposes to change the source of the API from the existing source (company 1) to to new source (company 2). In view of this change in the source of API, it is essential to determine whether it has any impact on drug product performance based on pharmacokinetic (PK) measures of total serum T4 and total serum T3 of the to-be-marketed formulation of levothyroxine (test formulation from company 2, Treatment A) relative to the formulation currently in the market (reference formulation from company 1, Treatment B).

This will be a single-center, open-label, two-period, two-treatment, two-sequence, randomized, single-dose, crossover study. 26 healthy adult males will be randomized to receive a single dose (6 x 100mcg tablets = 600mcg) of the test formulation of levothyroxine and reference formulation of levothyroxine separately in each treatment period. There will be two treatment sequences (AB, BA) and a 35 day washout between the two treatment periods.

The study will be conducted at BA/BE facility after approval from an independent ethics committee. Subjects will have a screening visit within 21 days prior to the first dose of study drug, two treatment periods with each containing a single dose of study drug, followed by 48 hours of serial PK sample collection. Subjects will check out of the unit on Day 3 (at 7am) after collection of the 48 hour PK sample. The subject will be instructed to return for the next treatment period or for the final follow-up visit, as appropriate. The final follow-up visit will occur 35 days after the last dose of study drug. Subjects will be assigned to each of the two treatments randomly as per the randomization schedule.
To compare the central corneal thickness measurement in patients with exfoliation, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma. Prospective study in progress. Randomly selected patients undergo a comprehensive ophthalmic exam which includes 2 separate pachymetry measurements in 2 different examinations at the same time of the day (10:00 am) with 3 different pachymeters. The values obtained are correlated with a number of other glaucoma parameters. A thinner cornea may represent a specific attribute and an additional risk factor for patients with exfoliation. Evaluation of corneal thickness is an important exam in the management of patients with exfoliation.
By 2030, an estimated 2 billion international tourist trips are expected annually worldwide, with citizens of Poland as important contributors. Illness rates among returnees from developing regions range between 43% and 79%. Properly diagnosing fever in these travelers is vital due to potentially serious implications. After visiting tropical and subtropical zones, the main health complaints are diarrhea, fever, and skin lesions. A reliable diagnosis begins with taking a comprehensive travel history and identifying potential risks. In travelers returning from sub‑Saharan Africa, malaria caused by Plasmodium falciparum is the main cause of fever, affecting 50 in every 1000 cases. Among returnees from Southeast Asia, dengue is dominant, occurring in 50-60 per 1000 cases, and its prevalence rises significantly nowadays. Other significant diseases include chikungunya, Zika, typhoid fever, amebic liver abscess, and occasionally viral hemorrhagic fevers. SARS‑CoV‑2 and influenza viruses are crucial pathogens as well. An in‑depth assessment of the travel history, combined with knowledge on tropical diseases, are key to the diagnostic process, and algorithms may be helpful in selecting appropriate tests and treatment methods.
Background: Most long-term care (LTC) residents live with dementia and the proportion with more advanced cognitive impairment is increasing. Residents with dementia often have limited functional ability to complete their activities of daily living (ADLs) and are vulnerable to further functional decline. Multicomponent exercise can help prevent functional decline, but residents with dementia are less likely to receive it and have not often been included in previous intervention studies. The Dementia Moves intervention was designed to fill this gap. It is an individually tailored multicomponent group exercise program with an aerobic warm-up and a focus on moderate to high intensity functional balance and strength training. Investigators will measure the feasibility and effect of the Dementia Moves program on ADLs for LTC residents with moderate to severe dementia (Mini-Mental State Exam of 20 or less). Investigators hypothesize the intervention will be feasible without modification if 16 individuals are recruited over 6 months, 65% of our sample is retained at 6-months, and 75% of the completed exercises are performed at a moderate to high intensity.

Methods: A pre-post pilot study will be used to assess feasibility, safety (rates of falls and adverse events), and change in ADLs at three- and six-months among LTC residents with moderate to severe dementia. A physiotherapist, physiotherapy assistant, and three volunteers will deliver the group-based exercise program to groups of four residents, three times per week, for six months. Assessments will be completed at three- and six-months. Feasibility outcomes include 1) recruitment over six-months; 2) retention at three- and six-month follow-up; and adherence via 3) attendance and 4) proxy and self-reported ratings of exercise intensity. Investigators will also assess fidelity of the intervention through program audits, and audio diaries and interviews to identify barriers and facilitators to implementation of the intervention.

Discussion: The feasibility of the Dementia Moves intervention will be evaluated in LTC residents with dementia, and investigators will examine rates of falls and adverse events and change in ADLs. Investigators will use the collected information to inform a definitive parallel cluster randomized controlled trial. The feasibility of the Dementia Moves intervention will be evaluated in LTC residents with dementia, and investigators will examine rates of falls and adverse events and change in ADLs. Investigators will use the collected information to inform a definitive parallel cluster randomized controlled trial.
Esters of penicillins or penicillanic acids with hydroxychalcones, esp. of formula (I): (where R1 and R2 are H, halogen, alkyl or NO2; and R3 is an acyl residue as found in known penicillins), have higher antibacterial activity than the corresp. unesterified penicillins. The esters are pref. prepd. by reacting an opt. substd. p-hydroxybenzaldehyde with acetophenone and using the resulting hydroxychalcone to esterify a penicillin.
PURPOSE:To smooth a weighing operation, by a method wherein a chemical agent high in frequency in use is stored in a memory while an exclusive numerical value code is set to the memory each time of use with respect to a chemical agent low in frequency in use and the memory is read by a detection means to fill a prescription according to indicated quantities. CONSTITUTION:When the powdered medicine A indicated in a prescription is registered in a ROM 2, a code reader 8 reads the code thereof to store the same in a RAM 3 and said code is displayed on a CRT 6. Next, the powdered medicine A is weighed by indicated quantity by an electronic balance 9 and data is stored in the RAM 3. At the time of unregistered powdered medicine B, a numerical number code and a chemical agent name are inputted to a backup RAM 4 from a keyboard 5 and subsequently read by the code reader 8 to be stored in the RAM 3 and both of them are displayed on the CRT 6. Next, the powdered medicine B is weighed by indicated quantity by the electronic balance 9 to store data in the RAM 3. A chemical agent of other formulation is also similarly processed. Lastly, the END key of the keyboard 5 is pushed to print the prescription by a printer 7. By this method, an unregistered chemical agent is subjected to data processing in the same way as an already registered chemical agent and registering capacity is reduced.
Trails directed at investigating differences in injury risk in relation to the focus of the running schedule have been conducted without any firm conclusions. People engaged in recreational running or choosing running as a new and active lifestyle needs guidance on which running schedules minimize the injury risk, aiding their chance of an active lifestyle and possibly reversing the increase in people developing a lifestyle disease. To develop running schedules minimizing the risk of injury, an understanding of the mechanisms that the different training variables impose on the human body is necessary. The existing literature on running intensity and the development of injuries show conflicting result. More studies are necessary to ascertain if there is a relationship between the intensity of running. In such studies, it is important to include other training variables in the analysis and to quantify running exposure using an objective method of measuring the relative intensity and absolute volume.
Although antiviral drugs can effectively inhibit hepatitis B virus (HBV) replication, the maintenance of chronic inflammation in the liver is still considered to be an important cause for the progression of HBV-related liver disease to liver fibrosis and advanced liver disease. As an endogenous inhibitory receptor of IL-1R and TLR signaling pathways, single immunoglobulin interleukin-1-related receptor (SIGIRR) has been proven to reduce inflammation in tissues to maintain system homeostasis. However, the relationship between SIGIRR expression and HBV replication and inflammatory pathway activation in hepatocytes remains unclear. In this study, hepatitis B virus X protein (HBx) upregulated MyD88 in liver cells, promoting NF-κB signaling and inflammatory factor production with LPS treatment, and the cell supernatant accelerated the activation and collagen secretion of hepatic stellate cells. However, SIGIRR overexpression suppressed HBx-mediated MyD88/NF-κB inflammatory signaling activation and inflammatory cytokine production induced by LPS in hepatocytes and HBV replication hepatocytes. Although we did not find any effect of SIGIRR on HBV replication in vitro, this study investigated the role of SIGIRR in blocking the proinflammatory function of HBx, which may provide a new idea for the treatment of chronic hepatitis B.
Spontaneous intracranial hypotension (SIH) commonly results from ventral spinal cerebrospinal fluid (CSF) leaks and epidural patches are advocated as first-line treatment. Complications such as superficial siderosis can arise but have previously been reported only in the context of long-term persistent, ongoing, CSF leak and SIH. We report a case of a patient with SIH from a ventral spinal CSF leak that was treated with epidural patching and experienced complete resolution of SIH. Four years later SIH symptoms recurred, and brain magnetic resonance imaging unexpectedly showed the interval accumulation of hemosiderin pigmentation on the cerebellum and brainstem during the period when the patient was without symptoms of SIH. This case uniquely demonstrates the progression of superficial siderosis despite the apparent resolution of SIH. Our findings suggest two divergent pathophysiological outcomes from spinal ventral dural tear: (1) CSF loss causing SIH; and (2) persistent low-level bleeding arising from the spinal dural tear leading to superficial siderosis. These divergent pathophysiologies had a discordant response to epidural patching. Epidural patching successfully treated the SIH but did not prevent the progression of superficial siderosis, indicating that some patients may require more than epidural patching despite symptom resolution. This case highlights the need for post-treatment monitoring protocols in patients with ventral spinal CSF leaks and SIH and raises important questions about the adequacy of epidural patching in certain SIH cases arising from ventral spinal CSF leak.
After post-phase I assessment, participants who are eligible will be randomized to 1) Continued SRI. For these participants, the medication (SRI) will be provided at a consistent dosage.
Subjects will have a screening visit within 30 days prior to the first dose of study drug, two treatment periods, and a follow-up visit 7-14 days after the last dose of study drug. Subjects in Arm 2 will receive GSK1349572 50 mg once daily for 7 days and GSK1349572 50 mg once daily in combination with rifabutin 300 mg once daily for 14 days.
Inadequate assessment, diagnosis, and stratification of patients with bone mass loss can lead to an increased risk of osteoporotic fractures. Therefore, alternative and advanced methods to support screening and diagnosis of osteoporosis (OP) are becoming increasingly essential, particularly considering specific gender differences. In this context, evaluating new methods and innovative techniques is a global challenge. To address this challenge, in 2018, the IRCCS Istituto Ortopedico Rizzoli (IOR) filed a European patent (European Patent No. 3008470, March 21, 2018; Inventors: Fini M, Giardino R, Salamanna F) related to an in vitro method for correlating the vitality of peripheral blood mononuclear cells (PBMCs) with bone metabolism alterations and OP through simple optical microscope observation. Additionally, specific gender-related differences have been observed in the number, size, differentiation time, and gene and protein expression profiles of PBMCs from osteoporotic patients of different sexes. In this context, the purpose of this study is to fully expand and develop the patent filed by IRCCS IOR in 2018 in order to: a) improve the understanding of the mechanisms of action and observed behavior in PBMCs on which the IOR patent is based; b) correlate the in vitro behavior of PBMCs with different levels of bone metabolism alteration (from osteopenia to fragility fractures); c) evaluate the correlation between the Dual-X-ray Absorptiometry (DXA) T-score and other blood factors related to OP (parameters related to platelets, pro- and anti-inflammatory cytokines, lymphocyte subpopulations) with the in vitro behavior of PBMCs in the presence of different levels of bone metabolism alteration, considering specific gender differences.
In this prospective study, we will recruit subjects into one of the three groups based on inclusion and exclusion criteria: 1) CN, 2) AD and 3) VCI. We will follow up with each of them subject at designated time points up to 2 years. We will collect demographic, medical, imaging (MRI and PET scans), genetic information and various biological samples (blood, saliva, urine and feces) during the study period. This study uses a case-control study design. The matched cases will have similar age, gender and education levels. By studying the relationship between risk factors of AD and VCI, we will establish norms and parameters in the Chinese population.
This group consists of participants who receive traditional medical massage for the treatment of acute ankle sprain. Interventions are conducted over three sessions, occurring on days 1, 8, and 15, with each session lasting 30 minutes. The medical massage aims to alleviate pain, improve muscle relaxation, and enhance overall functionality in daily activities. Participants' pain levels and functional capacity are assessed using the VAS pain scale and Roland-Morris questionnaire at both the beginning and end of the study period.