anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
STUDY DESIGN: Retrospective review of an adult deformity database.
OBJECTIVE: To identify pelvic incidence (PI) and age-appropriate physical function alignment targets using a component angle of T1-pelvic angle within the fusion to define correction and their relationship to proximal junctional kyphosis (PJK) and clinical outcomes.
SUMMARY OF BACKGROUND DATA: In preoperative planning, a patient's PI is often utilized to determine the alignment target. In a trend toward more patient-specific planning, age-specific alignment has been shown to reduce the risk of mechanical failures. PI and age have not been analyzed with respect to defining a functional alignment.
METHODS: A database of patients with operative adult spinal deformity was analyzed. Patients fused to the pelvis and upper-instrumented vertebrae above T11 were included. Alignment within the fusion correlated with clinical outcomes and PI. Short form 36-Physical Component Score (SF36-PCS) normative data and PI were used to compute functional alignment for each patient. Overcorrected, under-corrected, and functionally corrected groups were determined using T10-pelvic angle (T10PA).
RESULTS: In all, 1052 patients met the inclusion criteria. T10PA correlated with SF36-PCS and PI (R=0.601). At six weeks, 40.7% were functionally corrected, 39.4% were overcorrected, and 20.9% were under-corrected. The PJK incidence rate was 13.6%. Overcorrected patients had the highest PJK rate (18.1%) compared with functionally (11.3%) and under-corrected (9.5%) patients ( P <0.05). Overcorrected patients had a trend toward more PJK revisions. All groups improved in HRQL; however, under-corrected patients had the worst 1-year SF36-PCS offset relative to normative patients of equivalent age (-8.1) versus functional (-6.1) and overcorrected (-4.5), P <0.05.
CONCLUSIONS: T10PA was used to determine functional alignment, an alignment based on PI and age-appropriate physical function. Correcting patients to functional alignment produced improvements in clinical outcomes, with the lowest rates of PJK. This patient-specific approach to spinal alignment provides adult spinal deformity correction targets that can be used intraoperatively.
HBV presents a worldwide health crisis and is difficult to treat when a patient's HBV strain is no longer responsive to 3TC. Given the significant incidence of 3TC-resistant HBV in patients receiving this drug as part of an antiretroviral regimen, other agents with anti-HBV activity are needed. ADV has shown promising anti-HBV activity in preclinical assessments and in Phase I, II, and III clinical trials. TDF, developed for the treatment of HIV infection, has in vitro activity against HBV. This study will compare TDF/3TC combination therapy with ADV/3TC combination therapy to determine which treatment regimen is more effective in patients coinfected with HBV and HIV.

This study will include two populations of patients. Patients in Population A are on stable HAART that includes TDF and will either be in Group I (compensated liver disease) or Group II (decompensated liver disease). All patients in Population A will be randomly assigned to one of two arms: Arm 1 patients will receive 10 mg ADV daily and TDF placebo; Arm 2 patients will receive ADV placebo and 300 mg TDF. Patients in Population B are on stable HAART and have never taken TDF as part of their HAART. Population B patients will receive 300 mg TDF daily during the course of the study.

Study visits will occur every 4 weeks for the 96-week study period. Targeted clinical and medication assessments and blood work assessing clotting time, liver function, and blood chemistry will be conducted at each study visit. HIV and HBV DNA viral load will be tested every 12 weeks. CD4 cell counts will be tested at Weeks 24, 48, 72, and 96.
Distant metastases are common in most elderly patients, because elderly patients are diagnosed with advanced thyroid cancer due to delayed diagnosis. There is still few specific real-world data regarding prognosis in the elderly with differentiated thyroid cancer (DTC). The purpose of this study is to evaluate the prognostic factors and survival rate of elderly DTC patients with metastasis. This retrospective study included 14,603 elderly patients diagnosed with DTC from 2010 to 2015, including 447 patients with distant metastasis via the Surveillance, Epidemiology and End Results (SEER) database. The prognostic factors of overall survival (OS) and cancer-specific survival (CSS) in elderly DTC patients with metastasis or non-metastasis were determined by univariate and multivariate analysis. Age, primary site operation, radiotherapy, chemotherapy and tumor size are associated with OS and CSS in elderly DTC patients with distant metastasis. Compared with the patients without surgery, patients with total thyroidectomy showed significantly better OS. For the elderly DTC patients, radiotherapy was associated with improving OS and CSS. Chemotherapy increased the risk of death. For elderly DTC patients, early identification of distant metastasis, total thyroidectomy and radiotherapy are associated with better prognosis.
Patients apply MAL cream on the lesions and the surrounding normal skin. Beginning 3 hours later, patients undergo light emitting diode treatment for 5-10 minutes.
The invention relates to the field of health-care rabbit meat balls, in particular to a health-care rabbit meat ball which can prevent and cure hyperlipemia. The health-care rabbit meat ball is characterized by comprising the following raw materials, by weight part, of 100 parts of rabbit meat, 10-20 parts of pimpinella diversifolia traditional Chinese medicine micro powder, 2-5 parts of chopped onion, 1 part-5 parts of cooking wine, 10-20 parts of corn starch and 3-6 parts of salt. The pimpinella diversifolia traditional Chinese medicine micro powder is manufactured by pimpinella diversifolia, honeysuckle, kapok and Chinese yam according to the weight part ratio of 10:5-8:5-8:5-10. The health-care rabbit meat ball is fresh, sweet and mellow in taste, the taste of the rabbit meat ball is improved, and the health-care function of the rabbit meat ball is achieved. The honeysuckle, the Chinese yam and the like are used for conditioning the balance of the heart, the liver, the spleen, the lungs and the kidneys of the human body, regulating Qi, strengthening the spleen, removing thirst, dispersing blood stasis and removing turbid. The pimpinella diversifolia is used for activating blood and promoting menstruation to achieve the purpose of reducing blood fat. The rabbit meat ball is suitable for preventing and curing hyperlipemia and can achieve auxiliary food health care.
Patients will be integrated during the traditional day hospitalization follow-up, at the rate of 3 sessions per week. The patient will have 2 phases : phase A: CO-OP treatment during 6 week and phase B : without specific treatment during 3 weeks.
A pharmaceutical complex for radioprotection is disclosed, as well as its preparation method and applications. Within the pharmaceutical complex, the binding between Amifostine and natural microalgae is driven by osmotic pressure. The complex is gradually degraded in the gastrointestinal tract after oral administration. The degradation of the complex makes it thoroughly cover the intestine and slowly release the drug, thereby increasing the drug concentration in the small intestine, sufficiently exerting radioprotective effects on the intestinal tissues, and avoiding systemic toxicity to the gastrointestinal tract. Additionally, the pharmaceutical complex can function as supplementary nutritional substances and regulate intestinal inflammation. The excellent oral safety, feasible preparation, simple storage, and intake of the complex prompt absorption efficiency and oral safety settle the existing issues of drug preparation technologies. The pharmaceutical complex offers wide application prospects in the field of intestinal radioprotection.
The invention discloses a lansoprazole enteric coated tablet and a preparation method thereof. The core of the lansoprazole enteric coated tablet contains a medicinal excipient and lansoprazole as an active component, and the core is coated with an intermediate isolation layer and an enteric coating protective layer. The lansoprazole enteric coated tablet contains lansoprazole, one or more diluents, one or more disintegrating agents, an acidifying or alkalizing agent, an adhesive and one or more lubricants. The preparation method comprises the following steps of weighing lansoprazole, the one or more diluents, the one or more disintegrating agents and the acidifying or alkalizing agent according to prescription proportions, mixing uniformly, carrying out wet particle production by adopting an appropriate amount of the adhesive, drying wet particles obtained by the previous step at a temperature of 40 to 50 DEG C, finishing the dried particles, adding the one or more lubricants into the finished particles, mixing well, carrying out tabletting, coating an isolation layer and an enteric film coating layer on tablets obtained by the previous step, and packaging to obtain finished products. The lansoprazole enteric coated tablet contains sodium carbonate as an acidifying or alkalizing agent, has stable quality and is in favor of human health and safety. The preparation method has the advantages of simple prescription and process, short production cycle, high efficiency, low cost and easy production. The lansoprazole enteric coated tablet has the characteristics of good stability, rapid and stable releasing of active substances from the lansoprazole enteric coated tablet, and good clinical effects.
Objective. To evaluate patient characteristics and 5-year outcomes after surgical mitral valve (MV) repair for leaflet prolapse at a medium-sized cardiothoracic center. Background. Contemporary reports on the outcome of MV repair at medium-sized cardiothoracic centers are sparse. Methods. Patients receiving open-heart surgery with MV repair due to primary mitral regurgitation caused by leaflet prolapse between 2015 and 2021, without active endocarditis, were included. Clinical data, complications, re-interventions, mortality, and echocardiographic data were retrospectively registered from electronical patient charts, both pre-operatively and from post-operative follow-ups. Results. One hundred and three patients were included, 83% male, with a mean age of 62 years. All-cause mortality was 9% during a median follow-up time of 4.9 years. Re-intervention rate on the MV was 4%. Post-operative complications before last available follow-up visit at median 3.0 years were infrequent, with new-onset atrial fibrillation/flutter in 16%, post-operative MV regurgitation grade II or above in 17% and post-operative tricuspid regurgitation grade II or above in 14%. Conclusions. These data demonstrate that surgical MV repair for leaflet prolapse at a medium-sized cardiothoracic center was associated with low re-intervention rate and few severe complications. The presented results are comparable to data from surgical high-volume centers, indicating that surgical MV repair can be safely performed at selected medium-sized cardiothoracic centers.
BACKGROUND: While predictors for postoperative survival in spine tumour patients have been identified, there is limited evidence for predictors of postoperative Quality of Life (QoL), pain and functional outcome.
METHODS: One hundred and fifty-three consecutive patients, who had undergone surgery for symptomatic spinal metastases between June 2016 and April 2019, were interviewed preoperatively and during follow-ups at three, six and 12 months using the EQ-5D-3L, COMI, and ODI questionnaires. Differences in means exceeding the specific Minimal Clinically Important Difference (MCID) values were considered clinically significant.
RESULTS: Thirty-three percent of the patients were reported dead after 12 months. Only one metastasis compared to multiple metastases has 7.9 the Odds for an improved EQ-5D-3L score at three months. No neoadjuvant metastatic irradiation has 6.8 the Odds for the improvement at that time against performed radiation. A preoperative ODI score between 50.1 and 100 has 22.0 times the odds compared to the range from 0 to 50 for an improved EQ-5D-3L after three months, and 12.5 times the odds in favour of improved COMI after three months, and 13.6 times the odds for improvement of ODI at the three-month follow-up. A preoperative COMI score ranging from 5.0 to 10 has 21 times the odds of a COMI between 0 and 5 for an improved EQ-5D-3L score and 11 times the odds for an improved ODI after 12 months. Other predictors showed no statistically significant improvement.
CONCLUSION: An improvement in QoL, pain and spinal function after 12 months can be predicted by a subjective preoperative poor health condition. Impaired spinal function before surgery, a singular metastasis and no previous irradiation is predictive of improved spinal function and quality of life three months after surgery.
PURPOSE: A composition for improving or preventing hyperlipemia comprising pine tree extract as an active ingredient is provided to improve blood circulation and degradation of blood flow which are caused by excessive intake of cholesterol. CONSTITUTION: A composition for improving or preventing hyperlipemia comprises pine tree extract as an active extract. The pine tree extract is manufactured by using carbon dioxide with 50-70 kgf/cm^2 condition and Pinus densiflora Siebold et Zuccarini at 50-170deg.C for 100-300minutes with a sub-supercritical extraction method. A composition for improving or preventing hyperlipemia comprises pine tree extract as an active extract. A manufacturing method of food composition additionally comprises manufacturing of pine needles powder. A step of manufacturing pine needles powder is processed with hot air dry at 50-70deg.C and pulverization in order to maintain anti-oxidization active material of the pine.
This study aimed to examine the association between household water insecurity (HWIS), mother's handwashing practices, and childhood diarrhea in the peri-urban and informal settlements of Hosanna town. A community-based cross-sectional study involving 424 mothers was carried out in Hosanna town, and the data were collected using a pretested structured questionnaire, HWISE Scale, and an observational checklist. Bivariate and multivariable logistic regression models were used to analyze the data. The study revealed that the prevalence of HWIS and diarrhea among under-five children was 68.6% and 16%, respectively. Only 42.2% of the mothers had good handwashing practices. Good knowledge of handwashing, positive attitudes toward handwashing, household water security (HWS), and the presence of handwashing facilities were significantly associated with good handwashing practices. Children aged 6-11 months, HWIS, uncovered and wide-mouthed water storage containers, unsafe child's stool disposal practices, and hands not washed with soap after defecation, before preparing food, and feeding a child were significantly associated with the occurrence of diarrhea. The prevalence of diarrhea and HWIS was very high. The majority of the mothers had poor handwashing practices. Therefore, findings suggest interventions to improve HWS and mother's handwashing practices, which could reduce the risk of diarrheal diseases.
Example embodiments relate to determining prognosis and treatment based on clinical-pathologic factors and continuous multigene-expression profile scores. An example embodiment includes a non-transitory, computer-readable medium having instructions stored thereon. The instructions, when executed by a processor, cause the processor to execute a method. The method includes obtaining a plurality of clinical-pathologic factors related to a patient. The clinical-pathologic factors are indicative of risk associated with melanoma. The method also includes obtaining a continuous multigene-expression profile score for the patient. The continuous multigene-expression profile score is based on multiple genes whose expressions are related to melanoma. Further, the method includes determining, based on the plurality of clinical-pathologic factors and the continuous multigene-expression profile score, a risk score for the patient. In addition, the method includes outputting the risk score for use in determining a prognosis and treatment plan.
The proposed research assesses the feasibility of using an innovative application of the 2 x 2 factorial randomized controlled trial (RCT) design to examine the individual and combined effects of 1) lumbar medial branch nerve radiofrequency ablation (LRFA), a commonly used procedural intervention to target low back pain severity, and 2) a novel video telehealth tablet- and personal computer (PC)-based Activity Tracker-Informed Video-Enabled Cognitive Behavioral Therapy program ("AcTIVE-CBT"), a behavioral intervention designed primarily to target functional limitations both secondary to, and independent of, improvements in pain. The LRFA treatment to be used in the proposed study addresses the major patient selection, procedural/technical, methodologic and reporting limitations of prior studies. AcTIVE-CBT addresses problems with Veteran access and compliance associated with conventional cognitive behavioral therapy (CBT) delivered in clinic, and uses currently available activity tracking technology to better promote activity and behavior change as compared to conventional CBT. This pilot RCT involves recruitment of up to 30 Veterans with CLBP who will be followed to evaluate functional recovery for up to 3 months, to reach a goal of 20 Veterans completing the 3-month primary outcome. The primary outcome is participant-reported back-related functional limitations (mobility and ADLs) at 3 months, as measured by the validated Roland-Morris Disability Questionnaire. Secondary outcomes include activity tracker-assessed step counts, back pain intensity, reduction in opioid use, and quality of life. The investigators hypothesize that 1) each individual treatment will result in improvements in back-related functional limitations and secondary outcomes compared to control, and 2) combined treatment will produce greater treatment effects than each of the individual treatments alone. Although the proposed pilot study is unlikely to definitively address whether these treatments alone or in combination have significant effects on functional recovery, it will inform a future large-scale multicenter RCT to determine the efficacy of LRFA, AcTIVE-CBT, or combined LRFA + AcTIVE-CBT, for Veterans with CLBP.
A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities is provided to show wrinkle and elasticity improvement by the Chamaenerion angustifolium extracts having effects of inhibiting type I collagenase and AP-1. A composition containing Chamaenerion angustifolium extract with anti-wrinkle and antioxidant activities comprises Chamaenerion angustifolium extract obtained by adding water and alcohol or a mixed solvent thereof. The Chamaenerion angustifolium extract inhibits inflammation and improves skin elasticity. The composition has a formulation of external skin application. The composition represents cosmetics or health foods. The Chamaenerion angustifolium extract is an active ingredient in the composition.
Forty two post partum woman will recieve electrical stimulation for the rectus abdominis muscle day after day for 8 weeks. The patient position was relaxed in the crook lying position. The session parameters were 30 minutes/session with a low frequency current (50-100Hz).
During initial rest period, the volunteer remained seated for 10' in spontaneous breathing. During carrying out of the breath stacking technic, the volunteer remained seated, being requested to hold the mask on his/her face not allowing air scape, The volunteer was oriented to inhale normally and exhale all the air during expiration for 20 seconds. During the 20 seconds of applying of technic, in the three series the maximum inspiratory and expiratory pressures reached during the carrying out of technic. In the final rest period, right after technic end, the volunteers remained seated for 10 minutes in spontaneous breathing and again the same variables of control at the 10th minute were assessed.
Composition for nasal administration contain hPTH or a N-terminal fragment thereof. Preferred carriers are coated celluloses. Fragments are particularly [1-34]hPTH to [1-41]hPTH. Celluloses coated with fatty acid glycerides are also disclosed together with compositions containing a peptide and coated cellulose in powder form. HPTH fragment (1-36) is disclosed per se as new. Compositions are useful for treating e.g. osteoporosis.
The present invention discloses a youngia japonica heat clearing and toxin relieving black rice cake and a production method thereof. The black rice cake is prepared from the following raw materials in parts by weight: 100-120 parts of black glutinous rice, 30-40 parts of glutinous rice, 30-40 parts of panicum miliaceum, 10-20 parts of orange powder, 10-15 parts of coconut powder, 8-10 parts of traditional Chinese medicine powder, 2-4 parts of spice powder, and 2-4 parts of  sauce prepared from five kinds of flowers (Wuhua sauce). The traditional Chinese medicine powder is prepared from youngia japonica, broomjutre sida herb, gram chickpea seeds, barley, longhairy antenoron herb, herb of moellendorfs spidemoss, hibiscus rosasinensis flowers, celosia cristata stem leaves, vitis flexuosa vine juice, roughhaired holly roots, althaea rosea flowers, and dendrobium moniliforme. The main steps of the production method are as follows: grinding, Chinese traditional medicinal powder preparing, spice powder preparing, preparing of the sauce prepared from five kinds of flowers (Wuhua sauce), mixing, steaming, and shaping. The youngia japonica heat clearing and toxin relieving black rice cake is prepared from the purely natural raw materials. Combination of a Chinese herbal medicine formula and the rice cake is very important. The delicious rice cake is eaten by people, the physical symptoms of people can be effectively improved and the medicines are reasonable and effective in collocation. The rice cake has the efficacies of clearing heat and relieving toxins, inducing diuresis to reduce edema and stopping pains after being eaten for a long term.
This is a multi-centre, non-comparative, prospective post-market surveillance study involving surgeons skilled in shoulder replacement surgery. Each case enrolled will receive an Anatomical Shoulder Fracture implant. All system components are CE (Conformité Européenne)-marked and commercially available. Patients will be selected according to the subject selection criteria.

All patients will undergo pe-operative, intra-operative and post-operative physical examination, radiographic evaluation according to the hospital's routine procedure and collection of quality of life metrics. Follow-up evaluations are to be conducted at 6-12 weeks (x-rays only), at 6 months and annually thereafter for a minimum period of 5 years post hospital discharge. Follow-up evaluation at 10 years post hospital discharge is optional.
An investigator-blinded, prospective study of subjects with mild to moderate psoriasis will be conducted. Forty subjects ages 18 years and older will be enrolled.The Internet-based survey will be piloted to evaluate its effect on adherence to topical psoriasis medication. Subjects randomized in a 1:1 ratio to the Internet-survey group will log their impression of the state of their psoriasis on a weekly basis. Subjects in both the intervention and control groups will receive standard-of-care topical fluocinonide 0.05% ointment to be applied to affected areas on the skin twice daily. Adherence to fluocinonide will be assessed using Medication Event Monitoring System (MEMS®) caps, electronic monitors affixed to the medication containers. Investigators and subjects will be blinded to the adherence data until the final (Month 12) treatment visit.
Open label evaluation of ION283. All subjects with Lafora disease enrolled in this study will receive ION283.