anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
### Teratogenic Effects:

Pregnancy Category C. Animal reproduction studies have not been conducted with butalbital, aspirin, caffeine and codeine. It is also not known whether this combination product can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity and should be given to a pregnant woman only when clearly needed.

### Nonteratogenic Effects:

Although Butalbital, Aspirin, Caffeine with Codeine was not implicated in the birth defect, a female infant was born with lissencephaly, pachygyria and heterotopic gray matter. The infant was born 8 weeks prematurely to a woman who had taken an average of 90 Butalbital, Aspirin, Caffeine with Codeine capsules each month from the first few days of pregnancy. The child's development was mildly delayed and from one year of age she had partial simple motor seizures.

Withdrawal seizures were reported in a two-day-old male infant whose mother had taken a butalbital-containing drug during the last 2 months of pregnancy. Butalbital was found in the infant's serum. The infant was given phenobarbital 5 mg/kg, which was tapered without further seizure or other withdrawal symptoms.

Studies of aspirin use in pregnant women have not shown that aspirin increases the risk of abnormalities when administered during the first trimester of pregnancy. In controlled studies involving 41,337 pregnant women and their offspring, there was no evidence that aspirin taken during pregnancy caused stillbirth, neonatal death, or reduced birth weight. In controlled studies of 50,282 pregnant women and their offspring, aspirin administration in moderate and heavy doses during the first four lunar months of pregnancy showed no teratogenic effect.

Reproduction studies have been performed in rabbits and rats at doses up to 150 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to codeine.

Therapeutic doses of aspirin in pregnant women close to term may cause bleeding in mother, fetus, or neonate. During the last 6 months of pregnancy, regular use of aspirin in high doses may prolong pregnancy and delivery.
With dramatic improvement in survival of patients with hypoplastic left heart syndrome and related forms of single right ventricle undergoing staged palliation to the Fontan operation, a high prevalence of neurodevelopment abnormalities has been exposed. The NHLBI-funded Pediatric Heart Network (PHN) Single Ventricle Reconstruction (SVR) III study, "Long-term Outcomes of Children with Hypoplastic Left Heart Syndrome (HLHS) and the Impact of Norwood Shunt Type," is a prospective follow-up study of an existing cohort of children with HLHS and other single RV anomalies who were enrolled in early infancy in a randomized clinical trial of the modified Blalock-Taussig shunt (MBTS) versus right ventricular to pulmonary artery shunt (RVPAS). The parent SVR III study seeks to determine if the shunt assignment at the time of the Norwood operation is associated with cardiac function, transplant-free survival, exercise function, and neurodevelopmental outcomes. The investigators here propose a neuroimaging ancillary study to the parent SVRIII study that leverages the neurodevelopmental follow-up of the SVR cohort at age 11 years. The investigators will combine state-of-the-art brain imaging techniques \[Resting-Blood Oxygenation Level Dependent (BOLD) and Diffusion Tensor Imaging\] in 140 SVR III patients and 100 referent subjects with innovative brain connectome or "graph" analyses to determine if brain connectivity graph measurements will provide novel neuroimaging biomarkers for neurodevelopmental disabilities and improve the investigators' understanding of their inciting mechanisms in the SVR survivors. The investigators' specific aims are: Specific Aim (SA) #1: To characterize the global brain network topology of the SVR III cohort; SA #2: To determine which neurocognitive and behavioral outcomes predict global brain network topology in the SVR III cohort. SA #3: To determine which patient factors (e.g., birth weight, gestational age, maternal education) and medical factors (e.g., intraoperative conduct during Norwood procedure, hemodynamic complications, types and number of interventions, and measures of global morbidity) predict global brain network topology in the SVRIII cohort. SA #4: To precisely characterize the specific relationships between global brain network topology, specific patient/medical factors, and adverse neurocognitive/behavioral outcomes in the SVRIII cohort. The investigators will use linear regression and mediation statistical methods to analyze associations of MRI graph measures with SVRIII neurodevelopmental measures and surgical/non-surgical clinical independent risk factors. Upon successful completion, these studies will elucidate the nature and basis of neurodevelopmental disability in single ventricle patients following Fontan palliation. This research will also contribute a novel and robust set of clinical/research tools in the form of neuroimaging biomarkers that can be used to help classify and predict outcomes in complex congenital heart disease (CHD).
The invention discloses a processing method for the traditional Chinese medicine--Herba Pogostemonis. The method comprises the following steps: 1) harvesting, wherein Herba Pogostemonis can be harvested after cultivation in a paddy field for 6 to 8 m or cultivation in a dry field for 8 to 11 m; and 2) processing: a step of tedding harvested Herba Pogostemonis in a bleachery for several hours, layering, overlaying and stacking Herba Pogostemonis when the leaves of Herba Pogostemonis shrink, allowing Herba Pogostemonis to sweat for one night so as to enable branches and leaves of Herba Pogostemonis to become yellow, spreading and insolating Herba Pogostemonis the next day, then stacking and tightly covering Herba Pogostemonis for one light again and repeating spreading and insolating until Herba Pogostemonis is thoroughly dried. After packaging, Herba Pogostemonis should be stored in a dry and cool place and be prevented from dampness and heat. Fragrance of Herba Pogostemonis disappears when Herba Pogostemonis is stored for a long time, and the quality of Herba Pogostemonis is affected. Normally, 200 to 400 kg of dried Herba Pogostemonis is produced from each 667 square meters of fresh Herba Pogostemonis, with a drying rate being 4: 1. The processing method provided by the invention improves both the commercial grade and the output of Herba Pogostemonis, thereby increasing economic benefits; otherwise, years of hardworking and considerable investment have nothing in return caused by poor processing, which brings in great loss.
Up ontil now, only low reactivity Tzs can be radiolabeled via direct aliphatic S N 2. Unfortunately, these structures display too low reactivity for in vivo bioorthogonal chemistry approaches. Highly reactive structures such as mono-unsubstituted tetrazines (H-Tzs) have been reported to be highly sensitive to base. Extensive degradation is observed which prevents isolation of meaningful amounts for imaging studies. In the present invention there is provided a method providing the possibility to radiolabel base sensitive tetrazine structures with significantly improved RCYs. Even tetrazines that were previously not accessible by applying "standard" aliphatic  18 F-labeling strategies can be radiolabeled. This places new classes of  18 F-fluorinated compounds within reach for application in PET imaginge studies such as for diagnosis of cancers.
The invention, to be presented for use in hospitals and health institution, is a patient experience management system that measures performance by asking patients' opinions on the services provided in the hospitals and health institution using thorough questionnaires and analyze the patients' responses to score the performance, detect causes of performance alterations, and suggest solutions and prioritizing. This patient experience management system (1) has the following characteristics: using contacts of patient(s) (10) that are provided by hospitals and health institution (40), the patient(s) (10) are contacted and asked about their opinions on the provided services and treatments in the hospitals and health institution (40), the opinions of the patient(s) (10) are asked using thorough questionnaires (20). The responses of the patient(s) (10) on these questionnaires (20) questions are entered in a server (30) that has a built in Artificial Intelligence based matrix (31). The server (30) with its built in Artificial Intelligence based matrix (31) analyzes the responses and report the score, the Coefficient of Variation, the occurrence pattern, and trending. The server (30) with its built in Artificial Intelligence based matrix (31) then analyzes the score, the Coefficient of Variation, the occurrence pattern, and trending all together to report performance, detect causes of performance alterations, and suggest solutions and prioritizing. These results are then fed by the server (30) to the hospitals and health institution (40) on agreed intervals (real-time, weekly, monthly, etc.)
An oral powder Chinese medicine formula for treating lumbar disc herniation and osteoproliferation belongs to the field of oral powder Chinese medicine formulas. The Chinese medicine formula is composed of gamboge 50g, tabasheer 150g, red flower 150g, snake 150g, realgar 100g, diverse wormwood herb 150g, radix angelicae sinensis 50g, acacia catechu 100g, sodium sulfate 50g, frankincense 50g, gastrodia elata 100g, amber 20g, ground beeltle 150g, myrrh 50g, vitamin B1 500g and vitamin B6 500g. The total mass is 1420g. The oral powder Chinese medicine formula for treating the lumbar disc herniation and the osteoproliferation has the advantages of being simple in manufacture process, rich in raw material, low in production cost, small in investment scale and flexible. In addition, a patient can take a medicine simply and conveniently, the curative process is free of pain feeling, curative rate is high, curative effect is remarkable and the lumbar disc herniation and the osteoproliferation are not easy to relapse, curative cost is low, the patient can easily accept the cost and the like. The oral powder Chinese medicine formula is better than hormone treatment and operation treatment of western medicine, has wide popularization and treatment meanings and considerable market prospect.
BACKGROUND: There is limited literature comparing open and minimally invasive surgical (MIS) techniques for first ray dorsiflexion osteotomy (DFO). This study is the first of its kind to report early healing and complication rates of patients undergoing MIS vs open first ray DFO.
METHODS: A retrospective cohort review of 28 patients who underwent a first ray DFO procedure at an academic medical center between 2015 and 2024 was conducted. Demographic factors and medical comorbidities were recorded. Radiologic parameters were measured along with healing. Postoperative healing and outcomes were identified through medical record review.
RESULTS: Thirteen open and 15 MIS DFO procedures were performed. At follow-up, all osteotomies were healed with no wound or infection complications. There was no significant difference in hardware removal rates, 7.7% for open and 6.7% for MIS. The change in lateral Meary angle was 10.5 ± 3.9 and 9.7 ± 4.3 for the open and MIS groups, respectively (P = .61). The calculated dorsal closing wedge resection was 3.5 mm and 4.1 mm for open and MIS, respectively (P = .26).
CONCLUSION: This study showed no significant differences in healing or complication rates in the short term between MIS and open surgery, with comparable magnitude of correction, suggesting similar ability for the MIS technique to correct first ray alignment. Further studies are needed to determine long-term outcomes.
An Internet based health data system for providing patient medical, health, insurance and related data via the Internet, to a plurality of potential users including the patient based on profile and security that complies with all regulations including the HIPAA Act. The system registers and maintains an individual's health data by adding a meta-data wrapper thereto that then determines applicability-to-use cases defined by system logic. A patient profile is also used to recommend and independently search the Internet for appropriate information to benefit the patient and potential stakeholders and caretakers of the patient. Each profile and related data is interactively developed with regard to the individual patient and the other participant users including physicians, insurance institutions, hospitals, laboratories, family genetics, health care facilities, government agencies, etc. and stored in a relational database to be continuously updated through a patient's lifetime. The profiled health material is converted into contemporary, multi-tiered object oriented content utilizing Internet browser technology (i.e. HTML, VRML, HTTP/IIOP, Visual Basic, Active X, XML, RDF, Java-script, etc.) and integrated to the presentation level using object oriented technology and standards (e.g. OODBMS, Java, .jt, SQL, SOAP, CORBA, OLE, COM, etc.). The system is patient centric with a free web interface provided to the individual. Financial support is derived from the other stakeholders that can use this data. The system will constitute a single source of patient data that is secure and immediately accessible over the WWW to the appropriate stakeholders. The data is registered to the system and does not necessarily need to reside in a separate duplicated environment. All this data is converted in real time for standards based viewing across the WWW using standard browser technology.
Patients receive oral sunitinib malate once daily on days 1-28. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity.
Participants be placed on enalapril 10 mg and weaned off their other anti-hypertensives prior to the Pre-Treatment Assessment. Amlodipine (5 to 10 mg) will be added if needed to control blood pressure. After the Pre-Treatment Assessment, participants randomized to this arm will receive 50 mg eplerenone . At 2 weeks, eplerenone will be increased to 100 mg. Amlodipine (5 to 10 mg) will be added at 6 weeks or later if needed to achieve the BP target of \<135/85 mmHg.
Cross-matched allogeneic stored red cells will be rejuvenated using rejuvesol® Red Blood Cell Processing Solution (Citra Labs, MA, a Zimmer Biomet Company, IN, USA) with washing and re-suspension in an additive solution prior to transfusion. The rejuvenated red cells will then be administered to the patient as per standard practice and according to established institutional protocols. A maximum of 6 rejuvenated red cell units will be transfused within any 24 hour period.
BACKGROUND: Superficial temporal artery (STA)-middle cerebral artery (MCA) bypass surgery has been widely adopted in treating moyamoya disease (MMD). Geometric variations including high tortuosity and stenosis exist in many cases, but the hemodynamic effects have not been comprehensively evaluated. We aim to evaluate the hemodynamic effects of bypass geometry variations based on patient-specific data.
METHODS: In total, 17 patients with MMD who underwent STA-MCA bypass surgery with highly tortuous bypass geometry were included. For each patient, the original 3-dimensional structure of STA-MCA bypass was reconstructed from clinical imaging data. The bypass structure was virtually improved by removing the tortuosity and stenosis. Computational fluid dynamics simulation was performed on both bypass structures under identical patient-specific condition. The simulated hemodynamic parameters of the bypass and its distal branches were compared between the original and virtually improved bypass geometries in all cases using paired t-test or Wilcoxon signed-rank test. The changes of hemodynamic parameters were compared between the cases with and without mild-to-moderate stenosis (44.0-70.3% in diameter) in the bypass using t-test or Mann-Whitney U test.
RESULTS: The virtual improvement of bypass geometry significantly increased the flow rate of the bypass and its distal branches (P < 0.05) and decreased the transcranial flow resistance (P < 0.05). The hemodynamic changes in cases with stenosis removal were significantly greater than those without stenosis (P < 0.05).
CONCLUSIONS: High tortuosity and stenosis can significantly change the hemodynamics of STA-MCA bypass, and the optimization of bypass geometry deserves further consideration.
As bleeding disorders are a worldwide health concern, Saudi Arabia is experiencing a notable prevalence of such disorders. Studying the frequency and cause of hemostatic disorders is the key to successful clinical interventions and instigating effective public policies that limit the spread of such disorders. The current review aims to highlight the major findings of the body of literature that has investigated the causes, prevalence, and major challenges associated with bleeding disorders in the country. The current review summarizes the major findings of different studies that have been conducted in Saudi Arabia regarding different bleeding disorders. Multiple causes and symptoms of bleeding disorders have been reported by different studies. Some studies investigated the genetic aspect of bleeding disorders and revealed specific mutations in coagulation factor genes influencing the symptoms of different bleeding disorders. Moreover, rare bleeding disorders such as Glanzmann thrombasthenia and Henoch-Schönlein purpura, have been reported in different regions of Saudi Arabia. Combining clinical presentations, genetic factors, and epidemiological data, the current review of the literature provides a comprehensive insight into bleeding disorders in the kingdom. This will help in advancing the diagnostic capabilities and genetic counseling enhancing management strategies and therapeutic interventions benefiting bleeding disorder patients and the kingdom.
FIELD: medicine; otorhinolaryngology. SUBSTANCE: action period is preliminarily determined by means of lunar calendar. Action is effected with aid of independent electric stimulator of gastroenteric tract. Electric stimulator is kept in oral or nasal cavity 2-3 times a day within periods of the least activity of pericardium channels. Use is also made of three heaters and channel corresponding to main accompanying disease. In addition, patient keeps to diet which is combined with taking of sorbents. Phytotherapy, color therapy and aroma therapy are performed. Method makes it possible to render simultaneous effect in case of combined diseases of otolaryngological organs, mucous coat of oral cavity and paradontium. Method has practically no contraindications. It causes no complications. It is absolutely harmless, atraumatic and clean ecologically. It can be used at home. EFFECT: high therapeutic effect. 7 cl, 3 ex
The invention discloses a metoprolol tartrate sustained-release tablet and a preparation method thereof. The metoprolol tartrate sustained-release tablet is prepared from the following components in percentage by weight: 39-57 percent of metoprolol tartrate, 17-31 percent of retardant, 4-15 percent of adhesive, 9-24 percent of filler, 1-3 percent of lubricant, 1-2 percent of flow aid and 1-4 percent of coating premix. According to the preparation method, a method of twice separately granulating metoprolol tartrate and partial medicinal auxiliaries is adopted, and a fluidized bed is adopted for granulating. Compared with a traditional wet granulation method, the preparation method has the advantages that raw and auxiliary materials are separately granulated by the fluidized bed according to different properties, and play roles in improving particle fluidity, in particular resisting viscosity. The preparation is good in stability, good in releasing rate, and is beneficial to clinical use. The method is easy to operate, is suitable for large-scale industrial production, and has a higher application value.
AG-120 administered continuously as a single agent dosed orally on Days 1 to 28 of a 28-day cycle prior to surgery. Following surgery, subjects will have the option to receive treatment with AG-120 .
Radiofrequency ablation is a popular treatment for recurrent hepatocellular carcinoma (HCC),but still has a higher recurrence. Sorafenib as neo-adjuvant therapy in combination of RFA was not reported yet. There's a theoretical advantage of this combination. Hence in this study the efficacy and safety of pre-administrative Sorafenib and Latter radiofrequency ablation (RFA) in Recurrent HCC will be tested in a multicenter prospective cohort study. Eligible cases will be assigned into the experimental group and the control group. For experiment group, sorafenib tablet will be given for two weeks, and then perform radiofrequency ablation. For the control group, RFA will be performed immediately.
PURPOSE: To obtain a new compound exhibiting selectively excellent antifungal activity against fungi, hardly exhibiting toxicity to human and animals, scarcely having adverse effect, safe and useful as an antifungal agent applicable to a wide range of mycotic infections. CONSTITUTION: This compound is expressed by formula I (R<1> is H or an alkoxyalkyl; R<2> is a lower alkoxy, an amino, etc.; X is a halogen or a halogen- substituted phenyl; Y is a halogen or H), e.g. 3,3-dichloro-4-ethyl-1-(3- methoxymethoxy-4-methoxycarbonylphenyl)-2-pyrrolidinone. The compound is preferably obtained by reductively subjecting a salicylic acid-based compound of formula II (Z is Cl or Br) to cyclization reaction with a cyclization agent such as tributyltinhydride, Furthermore, the compound of formula II is preferably obtained by reacting, e.g. an alkyl 4-amino-2-alkoxyalkoxybenzoate with an alkyl 1-halogenated-2-butene to afford a new compound of formula III and reacting the compound with trichloroacetyl chloride, etc.
Patients receive medroxyprogesterone acetate IM on day 1 and entinostat PO on days 1, 8, and 15. Patients undergo hysterectomy between days 21-24.
Employing functional magnetic resonance imaging (fMRI) techniques, we conducted a comprehensive analysis of neural responses during sign language, picture, and word processing tasks in a cohort of 35 deaf participants and contrasted these responses with those of 35 hearing counterparts. Our voxel-based analysis unveiled distinct patterns of brain activation during language processing tasks. Deaf individuals exhibited robust bilateral activation in the superior temporal regions during sign language processing, signifying the profound neural adaptations associated with sign comprehension. Similarly, during picture processing, the deaf cohort displayed activation in the right angular, right calcarine, right middle temporal, and left angular gyrus regions, elucidating the neural dynamics engaged in visual processing tasks. Intriguingly, during word processing, the deaf group engaged the right insula and right fusiform gyrus, suggesting compensatory mechanisms at play during linguistic tasks. Notably, the control group failed to manifest additional or distinctive regions in any of the tasks when compared to the deaf cohort, underscoring the unique neural signatures within the deaf population. Multivariate Pattern Analysis (MVPA) of functional connectivity provided a more nuanced perspective on connectivity patterns across tasks. Deaf participants exhibited significant activation in a myriad of brain regions, including bilateral planum temporale (PT), postcentral gyrus, insula, and inferior frontal regions, among others. These findings underscore the intricate neural adaptations in response to auditory deprivation. Seed-based connectivity analysis, utilizing the PT as a seed region, revealed unique connectivity pattern across tasks. These connectivity dynamics provide valuable insights into the neural interplay associated with cross-modal plasticity.