anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the Phase 3 studies, no serious adverse event was considered related to study drug. A total of five patients, three in the active treatment groups and two in the vehicle group, experienced at least one serious adverse event. Three patients died as a result of adverse event(s) considered unrelated to study drug (stomach cancer, myocardial infarction, and cardiac failure).

Post-treatment clinical laboratory tests other than pregnancy tests were not performed during the Phase 3 clinical studies. Clinical laboratory tests were performed during conduct of a Phase 2 study of 104 patients and 21 patients in a Phase 1 study. No abnormal serum chemistry, hematology, or urinalysis results in these studies were considered clinically significant.

To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
After the warm-up period (5 minutes), the patient will be asked to cycle for 1 minute at a workload of 90% (high intensity) of the VO2max obtained from cardiopulmonary exercise test with a bicycle ergometer, and the patient will be asked to cycle for 2 minutes at a workload of 25% of the VO2max value. This cycle will be repeated 10 times. The patient will then be placed in a 5 minute cool-down period.
First, they perform two-minute chest compressions with conducting the PASAT. After 20 mins' rest, they perform two-minute chest compressions without conducting the PASAT.
During the I period, volunteers weekly consumed three 150g/serving Functional Meat (FM) products (cooked Ham and Turkey breast). It was firmly recommended that all other meats and meat derivatives had to be excluded from the diet.
PURPOSE:To obtain the titled coprecipitation product having high absorbability, improved solubility of cycloartenol ferulic acid ester which is a component of gamma-oryzanol, and increased remedying effect to autonomic imbalance, by adding a specific amount of PVP to the ester. CONSTITUTION:A coprecipitation product of cycloartenol ferulic acid ester and PVP can be produced by compounding 1pt.wt. of cycloartenol ferulic acid ester with >=1pt.wt., preferably >=3pts.wt. of PVP. The ester and PVP are dissolved in a solvent such as methanol, ethanol, etc., and the solution is adsorbed to a vehicle (e.g. gelatin, lactose, etc.). The ester is hardly soluble in water and has poor absorbability through the digestive tracts. The solubility and the absorbability through the digestive tracts can be improved and the pharmacological effects such as antiarteriosclerotic activity, gonadotropic activity, gonadotropic activity, etc., can be promoted by forming a coprecipitate.
LGX818 will be dosed on a flat scale of 300 mg (e.g., 3 x 100 mg capsules) once daily on a continuous dosing cycle. A complete treatment cycle is defined as 28 days. There will be no breaks between dosing cycles.
INTRODUCTION: Previous studies have established a history of shoulder dystocia as an important risk factor for shoulder dystocia, but studies on shoulder dystocia by severity are scarce. It is unknown if shoulder dystocia tends to be passed on between generations. We aimed to assess the recurrence risk of shoulder dystocia by severity in the same woman and between generations on both the maternal and paternal side. We also assessed the likelihood of a second delivery and planned cesarean section after shoulder dystocia.
MATERIAL AND METHODS: This was a population-based cohort study, using data from the Medical Birth Registry of Norway. To study recurrence in the same mother, we identified 1 091 067 pairs of first and second, second and third, and third and fourth births in the same mother. To study intergenerational recurrence, we identified an individual both as a newborn and as a mother or father in 824 323 mother-offspring pairs and 614 663 father-offspring pairs. We used Bayesian log-binomial multilevel regression to calculate relative risks (RR) with 95% credible intervals.
RESULTS: In subsequent deliveries in the same woman the unadjusted RR of recurrence was 7.05 (95% credible interval 6.39-7.79) and 2.99 (2.71-3.31) after adjusting for possible confounders, including current birthweight. The RRs were higher with severe shoulder dystocia as exposure or outcome. With severe shoulder dystocia as both exposure and outcome, unadjusted and adjusted RR was 20.42 (14.25-29.26) and 6.29 (4.41-8.99), respectively. Women with severe and mild shoulder dystocia and those without had subsequent delivery rates of 71.1, 68.9 and 69.0%, respectively. However, the rates of planned cesarean section in subsequent deliveries for those without shoulder dystocia, mild and severe were 1.3, 5.2 and 16.0%, respectively. On the maternal side the unadjusted inter-generational RR of recurrence was 2.82 (2.25-3.54) and 1.41 (1.05-1.90) on the paternal side. Corresponding adjusted RRs were 1.90 (1.51-2.40) and 1.19 (0.88-1.61), respectively.
CONCLUSIONS: We found a strong recurrence risk of shoulder dystocia, especially severe, in subsequent deliveries in the same woman. The inter-generational recurrence risk was higher on the maternal than paternal side. Women with a history of shoulder dystocia had more often planned cesarean section.
Water-soluble, organo specific, proteolytic enzymes, suitable for the treatment of leprosy, are prepared by macerating, in sterile physiological saline solution, an animal tissue for a period of time sufficient to reach maximum activity, this period of time being that necessary to produce a maceration liquid which will digest at least 7 of 10 different animal tissue substrates by the Abderhalden reaction (described) and (a) either precipitating the maceration liquid, after filtration, with a watermiscible organic solvent, separating the precipitate, elutriating the enzyme with physiological saline solution and, if desired, evaporating to dryness, or (b) heating the maceration liquid in an autoclave for about one hour at 120 DEG C., filtering and, if desired, evaporating to dryness. Step (b) is preferably carried out in the presence of animal tissue. Step (a) may be carried out by means of acetone, an alcohol or a mixture of these solvents. The enzymes may be activated by exposure to X-rays or ultraviolet rays. The starting material may be the suprarenal glands of pigs and oxen, the brains of goats, the spinal marrow of goats, the skin of goats, the testicles of oxen, the livers of goats and oxen, the thyroid glands of goats, hearts of oxen, and especially the muscle of goats and oxen or the lungs, cubital nerves or kidneys of goats.ALSO:A medicine for the treatment of leprosy comprises a solution in physiological saline of water-soluble, organic specific, proteolytic enzymes prepardd by macerating an animal tissue in sterile physiological saline solution for a period of time to reach maximum activity (see Group IV (b)). The starting material may be the suprarenal glands of pigs and oxen, the brains of goats, the spinal marrow of goats, the skin of goats, the testicles of oxen, the livers of goats and oxen, the thyroid glands of goats, hearts of oxen and especially the muscle of goats and oxen or the lungs, cubital nerves or kidneys of goats. The activity is improved by treatment with X-rays or ultra-violet rays. Optional additions are Vitamin C, penicillin and certain water-soluble, non-enzyme, constituents of animal tissues.
Background: Few original articles describe the perioperative outcomes of uniportal thoracoscopic segmentectomy using a unidirectional dissection approach. In this retrospective study, we evaluated the feasibility and safety of this procedure. Methods: This study included 119 patients who underwent uniportal thoracoscopic segmentectomy in our department between February 2019 and December 2022. The patients were divided into unidirectional (group U, n = 28) and conventional (group C, n = 91) dissection approach groups. While the dominant pulmonary vessels and bronchi were transected at the hilum without dissecting a fissure in the unidirectional (U) group, the dominant pulmonary artery was exposed and divided at a fissure in the conventional (C) group. Patient characteristics and perioperative outcomes were compared between groups U and C. Results: The proportions of simple and complex segmentectomies were statistically similar between the groups. The operating time was shorter (group U: 110 [interqurtile range: 90-140] min, group C: 135 [interqurtile range: 105-166] min, p = 0.012) and there was less blood loss (group U: 0 [interqurtile range: 0-0] g, group C: 0 [interqurtile range: 0-50] g, p = 0.003) in group U than in group C. However, there were no significant intergroup differences in other perioperative outcomes. Conclusions: The unidirectional dissection approach in uniportal thoracoscopic pulmonary segmentectomy is safe and feasible and enables a smoother operation.
Due to its absorption spectrum, changing concentrations of Indocyanine Green in the blood can be monitored by ear densitometry or by obtaining blood specimens at timed intervals. The technique for both methods is as follows. The patient should be studied in a fasting, basal state. The patient should be weighed and the dosage calculated on the basis of 0.5 mg/kg of body weight. 

Under sterile conditions, the Indocyanine Green for Injection USP powder should be dissolved with Sterile Water for Injection, USP. Exactly 5 mL of Sterile Water for Injection, USP, should be added to the 25-mg vial, giving 5 mg of dye per mL of solution. 

Inject the correct amount of dye into the lumen of an arm vein as rapidly as possible, without allowing the dye to escape outside the vein, (If the photometric method is used, prior to injecting Indocyanine Green, withdraw 6 mL of venous blood from the patient's arm for serum blank and standard curve construction, and through the same needle, inject the correct amount of dye.)

### Ear Densitometry: 

Ear oximetry has also been used and makes it possible to monitor the appearance and disappearance of Indocyanine Green without the necessity of withdrawal and spectrophotometric analysis of blood samples for calibration. An ear densitometer which has a compensatory photo-electric cell to correct for changes in blood volume and hematocrit, and a detection photocell which registers levels has been described. This device permits simultaneous measurement of cardiac output, blood volume and hepatic clearance of Indocyanine Green* and was found to provide a reliable index of plasma removal kinetics after single injections or continuous infusions of Indocyanine Green. This technique was employed in newborn infants, healthy adults and in children and adults with liver disease. The normal subject has a removal rate of 18-24% per minute. Due to the absence of extra-hepatic removal, Indocyanine Green was found to be ideally suited for serial study of severe chronic liver disease and to provide a stable measurement of hepatic blood flow. In larger doses, Indocyanine Green has proven to be particularly valuable in detecting drug-induced alterations of hepatic function and in the detection of mild liver injury. 

Using the ear densitometer, a dosage of 0.5 mg/kg in normal subjects gives the following clearance pattern. 

*Dichromatic earpiece densitometer supplied by The Waters Company, Rochester, Minnesota.
PURPOSE:To provide a flavivirus antigen containing at least one kind of epitope of V3 protein of flavivirus and effectively utilizable as a high-purity vaccine for Japanese encephalitis. CONSTITUTION:A Japanese encephalitis virus JaOArS982 strain is cultured by C6/36 cell culture originated from Aedes albopictus which is a kind of mosquito and a virus RNA is separated from supernatant liquid of the cultured product. cDNA is prepared from the virus RNA using an oligonucleotide (dGTACGGDTTCCCACATTTGGTCTCC) and cloned to a cloning vector pUC13. A clone S22 having a length of 2,500bp, containing 5'-terminal of virus RNA and containing a gene region coding V3 protein of Japanese encephalitis is separated from the cloned product. XboI linkers are linked to both terminals of the clone to obtain a clone S22X. A plasmid pJM105 for the manifestation of V3 protein gene is constructed by using a plasmid pS22X and a manifestation vector YEp133PCT.
OBJECTIVES: This study was aimed to develop a nomogram that can accurately predict the likelihood of cognitive dysfunction in individuals with abdominal obesity by utilizing various predictor factors.
METHODS: A total of 1490 cases of abdominal obesity were randomly selected from the National Health and Nutrition Examination Survey (NHANES) database for the years 2011-2014. The diagnostic criteria for abdominal obesity were as follows: waist size ≥ 102 cm for men and waist size ≥ 88 cm for women, and cognitive function was assessed by Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Word Learning subtest, Delayed Word Recall Test, Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). The cases were divided into two sets: a training set consisting of 1043 cases (70%) and a validation set consisting of 447 cases (30%). To create the model nomogram, multifactor logistic regression models were constructed based on the selected predictors identified through LASSO regression analysis. The model's performance was assessed using several metrics, including the consistency index (C-index), the area under the receiver operating characteristic (ROC) curve (AUC), calibration curves, and decision curve analysis (DCA) to assess the clinical benefit of the model.
RESULTS: The multivariate logistic regression analysis revealed that age, sex, education level, 24-hour total fat intake, red blood cell folate concentration, depression, and moderate work activity were significant predictors of cognitive dysfunction in individuals with abdominal obesity (p < 0.05). These predictors were incorporated into the nomogram. The C-indices for the training and validation sets were 0.814 (95% CI: 0.875-0.842) and 0.805 (95% CI: 0.758-0.851), respectively. The corresponding AUC values were 0.814 (95% CI: 0.875-0.842) and 0.795 (95% CI: 0.753-0.847). The calibration curves demonstrated a satisfactory level of agreement between the nomogram model and the observed data. The DCA indicated that early intervention for at-risk populations would provide a net benefit, as indicated by the line graph.
CONCLUSION: Age, sex, education level, 24-hour total fat intake, red blood cell folate concentration, depression, and moderate work activity were identified as predictive factors for cognitive dysfunction in individuals with abdominal obesity. In conclusion, the nomogram model developed in this study can effectively predict the clinical risk of cognitive dysfunction in individuals with abdominal obesity.
Alternative splicing (AS) is a crucial mechanism in post-transcriptional regulation, contributing significantly to the diversity of the transcriptome and proteome. In this study, we performed a comprehensive AS profile in nine tissues obtained from Duroc (lean-type) and Luchuan (obese-type) pigs. Notably, 94,990 AS events from 14,393 genes were identified. Among these AS events, it was observed that 80% belonged to the skipped exon (SE) type. Functional enrichment analysis showed that genes with more than ten AS events were closely associated with tissue-specific functions. Additionally, the analysis of overlap between differentially alternative splicing genes (DSGs) and differentially expressed genes (DEGs) revealed the highest number of overlapped genes in the heart and skeletal muscle. The novelty of our study is that it identified and validated three genes (PYGM, MAPK11 and CAMK2B) in the glucagon signaling pathway, and their alternative splicing differences were highly significant across two pig breeds. In conclusion, our study offers novel insights into the molecular regulation of diverse tissue physiologies and the phenotypic differences between obese- and lean-type pigs, which are helpful for pig breeding.
Carpal tunnel syndrome is the most common compressive neuropathy, occurring in 0.1 to 3% of the population. The incidence is reported to be higher in certain at risk populations. 87% of individuals exhibit bilateral symptoms. In patients who fail conservative treatment, surgery is indicated. To date, it is not know whether patients benefit from undergoing simultaneous or consecutive carpal tunnel release. Some patients express concern that having both hands operated on may make it impossible to perform necessary activities of daily living in the early postoperative period. Other patients express concern that having two surgeries increases their out of pocket cost, their total disability time, and lengthens the amount of time to resolution of preoperative symptoms. One previous study has attempted to characterize the differences in the effect on activities of daily living of these two treatment paradigms. This study was limited by the fact that there was no comparison group to the study cohort.

Cohort #1: Patients undergoing simultaneous bilateral carpal tunnel release. Inclusion criteria includes any adult patient indicated for bilateral carpal tunnel release. Exclusion criteria include age less than 18, pregnancy, any protected patient population, and the lack of assistance at home during the early postoperative period.

Cohort #2: Patients undergoing unilateral carpal tunnel release. Inclusion criteria include any adult patient indicated for unilateral carpal tunnel release. Exclusion criteria include age less than 18, pregnancy, and any protected patient population.

Once a patient has been identified in the clinic the consent process will begin. Consent will be administered by a member of the research team. Being part of this investigation will not change the standard treatment of carpal tunnel syndrome in any way. After surgery, patients will go home and be asked to fill out the Quick DASH, Levine-Katz Severity Score, WHO HPQ, and SF-6D on pre-operatively and at their first post-operative visit. They will also fill out an activities of daily living log that asks the patient to rate on a scale from 1 to 5 how much difficulty he or she has with each task on the list. The patient will return their ADL log to their physician on their first postoperative visit. A final postoperative visit will occur at 1 month. The investigational questionnaires will be filled out one last time at that visit. No long term follow up is required. Patients will be contacted on their first post-operative day to ensure receipt of the daily log, the day prior to the first post operative visit as a reminder to bring the log into clinic, and on the day before their last post-operative visit thanking them for participation in the study. During their final phone call patients will be asked what factors contributed to their decision to proceed or not proceed with undergoing bilateral carpal tunnel release.
Patients will receive 45 minutes of sham TENS therapy. All patients will receive ibuprofen.
PURPOSE:To obtain a TSG antibody, by prescribing a TSG antigen originated in a cancerous cell having a DBA-receptor to a mammal and collecting produced antibody. CONSTITUTION:It is indispensable to utilize an TSG antigen originated in a cancerous cell having a DBA-receptor as the antigen and the TSG antigen is obtained easily by separating the cell wall glycoprotein from a cancerous cell having a publicly known DBA-receptor e.g. tetratocarcinoma such as tetratocarcinoma OTT 6050 or tetratocarcinoma PCC3 etc. or a human gastric cancerous cell etc. and next, separating the substance combined with DBA from glycoprotein. The aimed antibody is obtained by prescribing TSG antigen to a mammal (rabbit or guinea pig) and collecting blood serum.
Mendelian randomization (MR) is an emerging tool for inferring causality in genetic epidemiology. MR studies suffer bias from weak genetic instrument variables (IVs) and horizontal pleiotropy. We introduce a robust integrative framework strictly adhering with STROBE-MR guidelines to improve causality inference through MR studies. We implemented novel t-statistics-based criteria to improve the reliability of selected IVs followed by various MR methods. Further, we include sensitivity analyses to remove horizontal-pleiotropy bias. For functional validation, we perform enrichment analysis of identified causal SNPs. We demonstrate effectiveness of our proposed approach on 5 different MR datasets selected from diverse populations. Our pipeline outperforms its counterpart MR analyses using default parameters on these datasets. Notably, we found a significant association between total cholesterol and coronary artery disease (P = 1.16 × 10-71) in a single-sample dataset using our pipeline. Contrarily, this same association was deemed ambiguous while using default parameters. Moreover, in a two-sample dataset, we uncover 13 new causal SNPs with enhanced statistical significance (P = 1.06 × 10-11) for liver-iron-content and liver-cell-carcinoma. Likewise, these SNPs remained undetected using the default parameters (P = 7.58 × 10-4). Furthermore, our analysis confirmed previously known pathways, such as hyperlipidemia in heart diseases and gene ME1 in liver cancer. In conclusion, we propose a robust and powerful framework to infer causality across diverse populations and easily adaptable to different diseases.
Pharmaceutical composition comprising sulfated oligosaccharides, particularly mono- and disaccharides, or their salts to enhance healing of wounds are described. Preferred saccharides are those having three or more sulfate groups, with persulfation being most preferred. Preferred salts are the soluble salts most preferably the alkali metal salts, particularly potassium and sodium salts. Sucrose octasulfate is the most preferred material. The saccharides may be present in any form, including liquids, gels or time release polymers. In preferred practice the saccharide is present in combination with collagen.
The invention relates to the use of alkaloid lolines to reduce parasitic infection in livestock and especially in ruminants, particularly sheep. The loline alkaloids are produced by and found in, grasses infected by endophytes. These grasses can be sown in areas where ruminants graze. Consumption of the grass supports the accumulation of loline alkaloids in the rumen of the animals and leads to a lower rate of infection by internal parasites and hence healthier livestock. The loline alkaloids may be produced by a number of endophytes present in a range of suitable grasses. The invention also provides a range of grasses which are suitable for the treatment of internal infection by parasites in livestock, especially ruminants and more especially sheep.