anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Remifentanil and other opioids are widely used as anesthetic sedation during minor surgical procedures and as pain relief in postoperative patients when the patient is spontaneously breathing and the airway is not secured by endotracheal intubation. In a previous study (not yet published) we showed that remifentanil induce pulmonary aspiration in healthy volunteers and the aim of this study is to objectively determine weather remifentanil infusion in healthy volunteers influence the pharyngeal phase of swallowing. The purpose is also compare the effect of remifentanil to morphine and younger volunteers to elderly volunteers. To assess this question we are going to study 24 volunteers, 12 younger and 12 elderly, who are randomised to receive remifentanil infusion with target concentration 3 ng/ml during 30 minutes at one occasion and an injection of morphine (younger: 0.1 mg/kg, elderly 0.07 mg/kg) at the other. The volunteers are asked to swallow 10 ml normal saline several times both before and after opioid administration and pharyngeal motility is parallelly recorded using combined manometry and impedance catheter placed transnasally into to the pharyngo-esophageal segment. Any subjective swallowing difficulties are also recorded.
The invention relates to a traditional Chinese medicine for curing psoriasis. The medicine mainly consists of tenuifolia, red peony, marron, ligusticum wallichii, ageratum, cimicifuga foetida, angelica root, mint, divaricate saposhnikovia root, radices platycodi, licorice and snake slough. The bulk drugs are mixed and then put in a pot. 1000 g of clean water is put in the pot for immersion lasting 1 h. A strong fire is used for boiling the bulk drugs in the water. A slow fire is used for slowly decocting the bulk drugs till only 400 g of water is left in the pot. The medicine is taken once a day when being cooled to room temperature. One treatment course involves continuous taking of 10 dosages of the medicine. Generally, the recovery from the psoriasis can be realized after 2-3 months. After the elimination of exterior skin lesions, the taking of the medicine needs to be continued for 2-3 more treatment courses for purpose of effect enhancement. According to the demonstration in clinical use, after a patient takes the traditional Chinese medicine for 2-3 months, the exterior skin lesions of the patient can be completely eliminated, the continuing use of the traditional Chinese medicine can prevent relapse, and the traditional Chinese medicine has no toxic or side effects and is properly priced.
The whole method is based on the principle of daughter cells (i.e. metastatic cells) maintaining the properties of their parent cells. In this case prostatic metastatic cells preserve the 5-α reductase, which is an essential enzyme for their nutrition; this is because they can not absorb testosterone without denaturating it assisted by 5-α reductase. Based on this property, the labelled 5-α reductase will be bound to metastatic body cells (tracking), while also mapping local metastatic invasion; additionally, in the parent region, it will map the population and spread of androgen receptors, providing extremely useful practical knowledge regarding androgen- dependence or not of the tumor (parent/metastatic tumor); I.e., a new innovative use of Dutasteride. In conclusion, the technical scope of our invention regards the innovative use of an agent already marketed (put to a completely different application) for: 1) creating/manufacturing standardized complexes / conjugated forms of radio-imaging (contrast) mediums using said substance. 2) Using the substance as a drug vector (standardization for each drug) for all already known and reported drugs; due to its forced binding to the tissues in question, fully targeted bonding of the potent load of chemotherapy drugs will be possible.
In the intervention group, there were 3 health-promoting conversations with each family after the discharge. The health-promoting conversations were held within an approximately 4- to 8-week period with an interval of 2 weeks between conversations. A closing letter was sent 2 to 3 weeks after the final conversation that summarized all of the conversations and that provided further opportunities for reflection.
The incidence of pressure injury in surgical patients about 12% to 45%, though these patients were treated with "gel pad" as routine. Based on the nutritional status of patients, long-term surgery, surgical posture, and anesthesia-induced hypotension, pressure injury still occurred. Sacral foam pad (Mepilex(®) Border Sacrum) is an unique 5-layer design, was designed to protect sacral pressure injury. In this study, we enrolled surgical patients who need to supine over ≧ 3 hours to evalute the effectiveness of sacral foam pad in preventing sacral pressure injury. The patients will randomized to control and intervention groups, both groups recruited 105 patients. In control group, patients use gel pad during surgery; whereas patients use gel pad in addition to sacrum foam pad (Mepilex(®) Border Sacrum) in intervention group. After surgery, the occurrence and severity of sacral pressure injury was evaluated. The results of this study can provide evidence to improve the awareness of operating room medical staff on surgical pressure injury, and find out the risk factors in avoiding of pressure injury, and offer an effective strategy to enhance the quality of surgery throughout the perioperative care.
Women treated with Menopur can participate with more than one cycle. 700 cycles will be enrolled.
This study was carried out in the northwest region of Misiones Province, Argentina, focusing on the clinical, pathological, epidemiological, and parasitological aspects of Eurytrema spp. in cattle. Clinical monitoring of five cattle cases exhibiting chronic weight loss revealed that affected animals had enlarged pancreases, with severe fibrosis and presence of Eurytrema coelomaticum in the pancreatic ducts. Histopathological analysis confirmed severe fibrosing periductal lymphoplasmacytic interstitial pancreatitis with intralesional trematodes. A cross-sectional epidemiological study was conducted from June 2018 to May 2021, involving 44 farms and 718 fecal samples. Coproparasitological analysis revealed a within-farm prevalence of 70.7 %, with an animal-level prevalence of 37.5 %. A multivariable generalized linear model identified the abundance of snails, the limited availability of monthly veterinary assistance, and loss of body condition as significant risk factors for Eurytrema sp. prevalence. Spatial analysis detected three significant clusters with varying prevalence levels, highlighting areas of high and low parasite occurrence. This study represents the first detailed investigation of Eurytrema sp. in Argentina, confirming its endemic presence in the central-northern region of Misiones Province. The findings underscore the need for further research to evaluate the parasite's spread across the province and its potential impact on livestock production.
The Peer-RESIM consists of 10 1.5-hour sessions (7-12 day intervals; 4 months), based on the modified CORE program manual and psychoeducation programs developed by the research team. The printed/online program is based on a self-care, personal plan for recovery workbook with 4 key components: personal recovery goals, plans to re-establish community functioning and support networks following a crisis, identifying early warning signs and creating a relapse prevention plan, and strategies and coping resources for problem-solving and maintaining wellbeing. After completing the recovery plan, participants will be empowered and supported by a peer-support worker and group members during scheduled sharing sessions.
PURPOSE:To provide the titled antiserum effective to the diagnosis of the infection with pine withering fungus, by administering the wood cellulase produced by the pine withering fungus belonging to Phomopsis genus to an animal. CONSTITUTION:Pine withering fungus belonging to Phomopsis genus (e.g. Phomopsis densiflora sp.) is cultured to obtain a wood cellulase. The enzyme (e.g. cellulase A) is purified, and is administered to an animal (e.g. rabbit) to obtain a wood cellulase antiserum. For example, a homogenate of 0.5mg of purified enzyme, 3ml of a mineral oil and 10mg of the antigen fungi is administered to a rabbit by hypodermic injection at 20-30 parts on the back. After 27 days, a homogenate of 0.1mg of the purified enzyme and 2ml of a mineral oil is administered as a booster to the forefood and hind leg of the rabbit by hypodermic injection. 31 days after the injection, the formation of the antibody is ascertained, the whole blood is collected through the carotid artery, and the serum is separated from the blood to obtain the objective antiserum.
OBJECTIVE: Home monitoring of 3-Hz spike-wave discharges (SWDs) in patients with refractory absence epilepsy could improve clinical care by replacing the inaccurate seizure diary with objective counts. We investigated the use and performance of the Sensor Dot (Byteflies) wearable in persons with absence epilepsy in their home environment.
METHODS: Thirteen participants (median age = 22 years, 11 female) were enrolled at the university hospitals of Leuven and Freiburg. At home, participants had to attach the Sensor Dot and behind-the-ear electrodes to record two-channel electroencephalogram (EEG), accelerometry, and gyroscope data. Ground truth annotations were created during a visual review of the full Sensor Dot recording. Generalized SWDs were annotated if they were 3 Hz and at least 3 s on EEG. Potential 3-Hz SWDs were flagged by an automated seizure detection algorithm, (1) using only EEG and (2) with an additional postprocessing step using accelerometer and gyroscope to discard motion artifacts. Afterward, two readers (W.V.P. and L.S.) reviewed algorithm-labeled segments and annotated true positive detections. Sensitivity, precision, and F1 score were calculated. Patients had to keep a seizure diary and complete questionnaires about their experiences.
RESULTS: Total recording time was 394 h 42 min. Overall, 234 SWDs were captured in 11 of 13 participants. Review of the unimodal algorithm-labeled recordings resulted in a mean sensitivity of .84, precision of .93, and F1 score of .89. Visual review of the multimodal algorithm-labeled segments resulted in a similar F1 score and shorter review time due to fewer false positive labels. Participants reported that the device was comfortable and that they would be willing to wear it on demand of their neurologist, for a maximum of 1 week or with intermediate breaks.
SIGNIFICANCE: The Sensor Dot improved seizure documentation at home, relative to patient self-reporting. Additional benefits were the short review time and the patients' device acceptance due to user-friendliness and comfortability.
All participants completing the Week 14 visit, irrespective of their response status, will continue in the OLE without unblinding of their baseline treatment group and will receive vedolizumab 300 mg, IV infusion, Q8W, on Days 99, 155, 211, 267, 323, and 379 (Weeks 14, 22, 30, 38, 46 and 54). Starting from Day 127 (Week 18) until the end of OLE Period up to approximately 58 weeks, participants who are nonresponders or who have disease worsening are eligible to receive 300 mg vedolizumab Q4W.
To test the extrapolation capabilities of the deep learning sysyem, two independent datasets, the Joint Five-site Fundus Test (JFFT) and the Hong Kong Children Eye Study (HKCES), were applied as external test sets. The JFFT study, a multi-site dataset, contains cross-sectional data from Shanghai, Yunnan, Inner Mongolia, Xinjiang and Guangzhou. HKCES, a population-based cohort study of eye conditions in children aged 6-8 years.
Innovations in kidney transplantation have improved short-term outcomes for transplant patients. However, organ rejection remains as an important threat to the long-term survival of the transplanted organ. If clinicians could better monitor the condition of the organ after transplantation, they may be able to improve the chance of graft survival. Noninvasive ways to monitor the condition of the transplanted organ need to be developed and tested. This observational study will investigate whether certain blood and urine tests are useful in monitoring the health of transplanted kidneys.

This trial will involve 14 post-transplant study visits over the course of 2 years. A physical exam, medication history, adverse events assessment, and blood and urine collection will occur at all visits. Kidney biopsies will occur at study entry prior to transplantation and at Month 6, in adult participants only. Protocol biopsies are optional in the pediatric substudy group. Additional visits may be required if organ rejection is suspected.
PROBLEM TO BE SOLVED: To provide a composition containing methyl cellulose, used for oral cavities, and scarcely changing the viscosity with the passage of time. SOLUTION: This composition for oral cavities contains methyl cellulose. Therein, (i) polyoxyethylene-cured caster oil and/or (ii) polyoxyethylene/ polyoxypropylene copolymer are added. The polyoxyethylene/polyoxypropylene copolymer used therein is a block copolymer comprising a polyoxyethylene portion A and a polyoxypropylene portion B. The polyoxyethylene portion A is contained in the 60-90 wt.%, preferably 70-85 wt.%, in the molecule, and the polyoxypropylene portion B has a mol.wt. of 2,000-4,500, preferably 2,500-4,000.
Swedish massage session of 30 minutes duration, once weekly for eight weeks over a eight (8) week period. Total intervention = 8 sessions for 240 minutes.
FIELD: medicine, pharmacy. SUBSTANCE: composition has the surface antigen of hepatitis B virus and protein of yeast Saccharomyces cerevisiae as active components. Glucose and polyglucin at their mass ratio = (1:1)-(10:1) are used as vehicles and stabilizing agents. Indicated components are used as dried substances. Also, composition has additional substances. Composition has 100-200 mcg HBsAg of surface antigen of hepatitis B virus, 0.05-12 mg protein of yeast Saccharomyces cerevisiae, 10-50 wt.-% of glucose with polyglucin and up to 100 wt.-% of additional substances per unit of ready form. Antigen is obtained, in part, by culturing the strain Saccharomyces cerevisiae VKPM Y-2203. Composition can contain 0.8-1 wt.-% of calcium stearate, 50-55 wt. -% of dehydrated lactose as additional substances and composition is made as a tablet. Tablet is covered by acetylphthalylcellulose shell taken at mass 0.4-0.5% of total sum of all tablet components. Composition is stable, can be stored for a long time, easily for using and does not cause adverse reactions. This tablet form shows more facility as compared with injection forms and provides safety and rapid vaccination of many people without using the special equipment and qualified staff for immunization carrying out. EFFECT: improved quality and properties of composition. 6 cl, 2 tbl, 3 ex
PURPOSE: Emerging research indicates a link between the intake of fatty fish and age-related macular degeneration (AMD). However, observational studies fall short in establishing a direct causal link between oily fish intake and AMD. We wanted to determine whether causal association lies between oily fish intake and age-related macular degeneration (AMD) risk in human beings.
METHODS: This two-sample mendelian randomization (MR) study used the MR method to probe the genetic causality in the relationship between oily fish intake and AMD. The genome-wide association study (GWAS) data for AMD were acquired from a Finnish database, whereas the data on fish oil intake came from the UK Biobank. The analysis used several approaches such as inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode MR. In addition, the Cochran's Q test was used to evaluate heterogeneity in the MR data. The MR-Egger intercept and MR-pleiotropy residual sum and outlier (MR-PRESSO) tests were used to assess the presence of horizontal pleiotropy. A leave-one-out sensitivity analysis was conducted to determine the reliability of the association.
RESULTS: The IVW method revealed that the intake of oily fish is an independent risk factor for AMD (P = 0.034). It also suggested a minimal likelihood of horizontal pleiotropy affecting the causality (P > 0.05), with no substantial heterogeneity detected in the genetic variants (P > 0.05). The leave-one-out analysis confirmed the reliability and stability of this correlation.
CONCLUSIONS: This research used a two-sample MR analysis to provide evidence of a genetic causal relationship between the eating of oily fish and AMD. This discovery held potential significance in AMD prevention.
BACKGROUND: Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological stimuli. Recently, we have found that the decrement of carboxypeptidase E (CPE) with aging impairs the maturation of brain-derived neurotrophic factor (BDNF) and neurogenesis in the SVZ. However, it remains unknown whether these events occur in the hippocampus, and what the role of CPE is in the adult hippocampal neurogenesis in the context of Alzheimer's disease (AD).
METHODS: In vivo screening was performed to search for miRNA mimics capable of upregulating CPE expression and promoting neurogenesis in both neurogenic niches. Among these, two agomirs were further assessed for their effects on hippocampal neurogenesis in the context of AD. We also explored whether these two agomirs could ameliorate behavioral symptoms and AD pathology in mice, using direct intracerebroventricular injection or by non-invasive intranasal instillation.
RESULTS: Restoration of CPE expression in the hippocampus improved BDNF maturation and boosted adult hippocampal neurogenesis. By screening the miRNA mimics targeting the 5'UTR region of Cpe gene, we developed two agomirs that were capable of upregulating CPE expression. The two agomirs significantly rescued adult neurogenesis and cognition, showing multiple beneficial effects against the AD-associated pathologies in APP/PS1 mice. Of note, noninvasive approach via intranasal delivery of these agomirs improved the behavioral and neurocognitive functions of APP/PS1 mice.
CONCLUSIONS: CPE may regulate adult hippocampal neurogenesis via the CPE-BDNF-TrkB signaling pathway. This study supports the prospect of developing miRNA agomirs targeting CPE as biopharmaceuticals to counteract aging- and disease-related neurological decline in human brains.
BACKGROUND: Heart transplantation remains the most definitive therapy for qualified candidates with end-stage heart failure. Concomitant kidney disease is common in this population prompting an increase in simultaneous heart-kidney (SHK) transplantation in recent years. The goal of our study was to explore the effects of the 2018 heart allocation policy (HAP) change on candidate listing characteristics and compare survival rates at 1 y in patients that were supported with a left ventricular assist device (LVAD) pretransplant and underwent SHK or heart alone transplant (HAT).
METHODS: We used data from the Scientific Registry of Transplant Recipients and identified all adults who underwent primary SHK or HAT between January 2010 and March 2022. Recipients supported with a durable LVAD and estimated glomerular filtration rate <60 mL/min/1.73 m 2 were selected (n = 309 SHK; 217 pre- and 92 post-HAP and n = 3,324 HAT; 2738 pre- and 586 post-HAP).
RESULTS: Difference in survival at 1 y did not reach statistical significance. Comparing the 1-y survival of SHK and HAT recipients who were bridged with LVAD pre-HAP, we found no significant difference ( P = 0.694). Adjusting for the same covariates in a multivariable model did not affect the results (SHK versus HAT hazard ratio 0.84 [0.51, 1.37]; P = 0.48). In contrast, SHK recipients supported with an LVAD who were listed and transplanted post-HAP change had significantly lower 1-y survival, when compared with HAT ( P = 0.037).
CONCLUSIONS: Our findings suggest that the HAP change had a potentially negative impact on the survival of select patients undergoing SHK transplant. Further research is warranted in this area.
Limited research has been performed to determine if histologic improvement serves as a prognosticator for endoscopic remission, a key therapeutic target for ulcerative colitis (UC). The primary aim of the study was to evaluate if histological activity could predict endoscopic remission in UC patients with Mayo endoscopic subscores (MES) of 0 or 1. In addition, we compared the clinical outcomes between histologic improvement group and active group. This research encompassed 492 individuals with UC with MES of 0 or 1, who underwent histological assessment as per the established protocol of Samsung Medical Center between January 2018 and December 2020. Participants were categorized into two cohorts based on the degree of histological activity: those showing histologic improvement and those with ongoing histologic activity. The endoscopic activity was assessed during follow-up, and the primary outcome was endoscopic remission according to histologic activity. Out of the total participants, endoscopic activity was scrutinized in 435 patients during the colonoscopic follow-up and in 146 during the subsequent one. The histologic improvement group at the index colonoscopy was more likely achieve endoscopic remission than the histologic active group. Clinical relapse was more likely in the histologic active group than in the histologic improvement group.
The invention belongs to the technical field of health care products, and relates to a preparation method of water-soluble cannabidiol-containing health care tea. The invention aims at the development prospect of domestic market and international market and aims at developing a preparation method of water-soluble cannabidiol-containing health-care tea. The water-soluble cannabidiol is prepared by an inclusion method, the water-soluble activity of CBD is improved, and the comprehensive synergistic effect is exerted by matching with the traditional Chinese medicinal materials in the formula. The invention has the advantages that: 1. the water-insoluble cannabidiol is embedded with high-purity CBD by an inclusion method on the premise of not changing the molecular structure, so that the water solubility, the stability and the bioavailability of the CBD are greatly improved, the effect is fully exerted, and the application field of the CBD is widened. 2. The extraction of the raw materials can fully dissolve out the raw material components, and the efficacy of the raw materials can be better exerted. The product has unique flavor and obvious health care effect, has the effects of clearing away heat and toxic materials, resisting inflammation, resisting oxidation, regulating immunity and the like, and is health care tea integrating beauty, health preservation and leisure.