anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the field of medicines, and particularly discloses application of daidzein in preventing and treating heart related diseases. Application of daidzein in preparing medicine for preventing and treating myocardial fibrosis is provided. Application of daidzein in preparing medicine for preventing and treating diseases caused by myocardial fibrosis is provided. Application of daidzein in preparing medicine for preventing and treating infarction of heart tissue is provided. Application of daidzein in preparing preparation for inhibiting myocardial fibroblast inflammatory factor expression is provided. The application of daidzein in preparing preparations for inhibiting TGF/Smad signal path or TGF-beta 1 expression. Application of daidzein in preparing preparation for inhibiting proliferation of myocardial fibroblast is provided. The medicine for preventing and treating myocardial fibrosis contains soybean extract as effective component. An inhibitor of TGF-beta 1 expression or an inhibitor of TGF/Smad signaling pathway, comprising daidzein as an active ingredient. The invention discloses that Daidzein has an inhibiting effect on TGF/Smad signal channels, so that Daidzein can inhibit myocardial fibroblast inflammation, thereby preventing and/or treating diseases caused by myocardial fibroblast inflammation.
BACKGROUND Conjoined twins are a rare congenital anomaly with various types, depending on the connection site. Managing these cases requires a structured approach leading to separation surgery. This report provides a detailed description of the anesthetic strategies and challenges of pygopagous conjoined female twins who underwent 2 surgeries before separation at 17 weeks of age. CASE REPORT The female twins were conjoined at the sacral level (S4), with fused thecal sacs at L5 and cord tethering, with the conus terminating below L3 in both patients. They had separate rectal ampullae that fused into a single anal canal in the midline in a Y formation. The babies underwent 2 surgeries prior to separation: meningocele repair for twin B and anal canal dilation and sphincter mapping for both twins, followed by a ventriculoperitoneal shunt insertion for twin B. The separation surgery included dividing the bony vertebral fusions and dural sacs, untethering the spinal cords and nerves, and correctly allocating the intrapelvic muscles, guided by sphincter muscle mapping. Anesthesia was managed by 2 distinct teams each time, with duplicated equipment and color-coded medications to prevent errors. Due to the critical condition of twin B, general anesthesia was administered to her first. The report also addresses the challenges faced during the 3 surgical procedures. CONCLUSIONS Anesthetic management for pygopagus twins presents complex challenges. Despite limited experience with similar cases, successful management was achieved through planning, effective communication, and rehearsal of unfamiliar setups. Attention to detail and involvement of highly experienced teams were crucial to the success of the procedures.
FIELD: medicine, pharmacy. SUBSTANCE: agent is made as rectal suppositorium. An agent has an active component showing the expressed analgetic, antipyretic and antiinflammatory effect - analgin taken at the dose 0.09-0.11 or 0.225-0.275 g per suppositorium. Solid confectionery fat based on hydrogenated fat or a mixture of triglycerides of natural food fatty C 12 -C 18 -acids with mono- and diglycerides of the indicated acids are used as a base. New medicinal form provides arresting different pains and fever state at influenza, rheumatism and in postoperative period and accelerates curative effect due to rapid absorption of drug in blood. EFFECT: enhanced effectiveness of an agent proposed. 2 cl, 6 tbl
A total of 12 hours of Evidence-Based Education intervention was applied to students in the intervention group, spread over 7 sessions. The educational intervention was created in line with the literature. No application was given to the students in the control group. Data were collected using the Students' Knowledge, Attitudes and Behavior Towards Evidence-Based Nursing Scale and the Nursing Students' Awareness and Attitudes Towards Research and Developments in Nursing Scale.

Paired Sample T test and Wilcoxon test will be used in pre-test and post-test comparisons. Mann Whitney U, Kruskal Wallis, One Way Anova test will be applied to determine the difference between groups. Statistical significance level was accepted as p˂0.05.
Case reports in the literature have shown that co-administration of carbapenems, including Imipenem and Cilastatin for Injection (I.V.), to patients receiving valproic acid or divalproex sodium results in a reduction in valproic acid concentrations. The valproic acid concentrations may drop below the therapeutic range as a result of this interaction, therefore increasing the risk of breakthrough seizures. Increasing the dose of valproic acid or divalproex sodium may not be sufficient to overcome this interaction. The concomitant use of Imipenem and Cilastatin for Injection (I.V.) and valproic acid/divalproex sodium is generally not recommended. 

Antibacterials other than carbapenems should be considered to treat infections in patients whose seizures are well controlled on valproic acid or divalproex sodium. If administration of Imipenem and Cilastatin for Injection (I.V.) is necessary, supplemental anti-convulsant therapy should be considered [see Drug Interactions ( 7.3)].  Close adherence to the recommended dosage and dosage schedules is urged, especially in patients with known factors that predispose to convulsive activity.
BACKGROUND: To investigate microbial characteristics across multibody sites from chronic pancreatitis (CP), through pancreatic benign tumors, to pancreatic ductal adenocarcinoma (PDAC) at different stages.
METHODS: 16S ribosomal RNA (rRNA) amplicon sequencing was conducted on saliva, duodenal fluid, and pancreatic tissue obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of patients with CP, pancreatic benign tumors, PDAC in stage I/II, III, and IV. The neutral community model (NCM) assessed the microbial assembly contribution and MaAslin2 identified the differential microbes.
RESULTS: From CP to stage IV PDAC patients, there was a marked surge in influence of salivary and duodenal microbiota on constitution of pancreatic microbial communities. Our observations revealed a successive alteration in microbial species across various bodily sites during PDAC tumorigenesis. Notably, Porphyromonas gingivalis, Treponema denticola, Peptoanaerobacter stomatis, Propionibacterium acidifaciens, Porphyromonas endodontalis, Filifactor alocis, etc., sequentially increased along PDAC progression in pancreatic tissue, whereas bacteria commonly used as probiotics Bifidobacterium breve, Lactiplantibacillus plantarum, etc., declined. Furthermore, the sequentially escalating trends of Peptoanaerobacter stomatis and Propionibacterium acidifaciens during PDAC tumorigenesis were mirrored in duodenal fluid and saliva. Porphyromonas gingivalis, Porphyromonas endodontalis, and Filifactor alocis, which intensified from CP to stage IV PDAC in pancreatic tissue, were also found to be enriched in saliva of patients with short-term survival (STS) compared with those with long-term survival (LTS).
CONCLUSIONS: Salivary and duodenal microorganisms were prominent factors in shaping pancreatic microbial landscape in PDAC context. Further exploration of these microbial entities is imperative to unravel their specific roles in PDAC pathogenesis, potentially yielding insights for future therapeutic strategies.
That program was created by sending 40-minute videos 1 day a week for 8 weeks. The programme was developed both according to the achievements of previous self-management studies and according to the occupations that individuals with SSc have difficulty with.
The invention relates to a method for developing an active ingredient capable of directly or indirectly influencing, preferably in an intracellular manner, the function of physiologically active peptides or proteins. The influence on the function of the peptides or proteins preferably takes the form of an inhibition of said function. According to the method, first a target peptide or target protein which is able to or does physiologically participate in a peptide-peptide or protein-protein interaction is identified and selected. Usually only the identification or selection or one or more fragments of said peptide or protein is necessary. Secondly an amino acid sequence is derived or screened which interacts with the target peptide or target protein or with fragments thereof with high affinity. The derived amino acid sequence interacts with the target peptide preferably at least as well as and especially better than with its physiological interaction partner.
<P>PROBLEM TO BE SOLVED: To select a suitable image which an observer wants to see from a group of medical images, and display it.  <P>SOLUTION: Thumbnail image data is formed according to medical image data in a modality apparatus 1 creating medical image data, and the thumbnail image data is connected with the identification information of medical image data and transmitted to an observation apparatus 2 connected through a network 3. Next, the thumbnail image data received on the observation apparatus 2 are classified in a plurality of ranks and displayed in stages. Next, the identification information of medical image data according to the thumbnail image selected on a window is transmitted to the modality apparatus 1 as acquisition request information. Additionally, the medical image data transmitted from the modality apparatus 1 to the acquisition request information is displayed on the observation apparatus 2.  <P>COPYRIGHT: (C)2010,JPO&INPIT
PURPOSE:To obtain buckwheat tea useful for long life and promoting health, by removing impurities, etc. attached to unpolished seeds of buckwheat, washing them with water, immersing them in water, steaming, drying, peeling and sieving them into three groups, roasting them separately, blending them with herbs which are steamed, and roasted. CONSTITUTION:Admixtures, mud, impurities, etc. attached or blended in seeds of unpolished buckwheat are removed from unpolished buckwheat seeds, the selected buckwheat seeds are washed with water and immersed in water for about 2hr, taken out, steamed for about 40min, and dried with hot water into about 14wt% water content. The seeds are peeled with a peeler, and sieved by a seiving machine into three kinds of 60wt% middle seeds of spherical grain, 30wt% seeds of original form, and 5wt% cracked seeds, and roasted separately by a roasting device. Respectively proper amounts of herbs of Lycii fructus, Cassiae torosa Cav., Geranic herba, and Kishimame cha blended and washed with water. They are steamed for about 40min by a steamer, dried, cut into pieces, and roasted by a roasting machine. 100pts.wt. buckwheat is blended with 10pts.wt. herbs, to give the desired buckwheat tea.
Stress is a psychosocial factor that affects students' academic performance and well-being. The presence and level of stress have a positive or negative impact on learning and thinking, and students show behavioral, emotional, and physical symptoms of experiencing stress For this reason, it is very important for university students to apply stress reduction methods, especially non-drug methods. Progressive relaxation and deep breathing exercises with music are effective methods of coping with stress. When the literature is examined, it is seen that the use of music has recently been effective in reducing the anxiety and stress experienced by many students during the education process. At the same time, a progressive relaxation exercise integrated with deep breathing exercises helps a person to feel the difference between tension and laxity in the body and allows the person to learn to relax on their own, thus reducing physical and emotional tension. Thus, the individual moves away from disturbing stimuli that reduce the quality of life such as anxiety, pain, and stress. In accordance with the nursing education program carried out with theoretical and practical application course hours, students considering the stress they are exposed to and the behavioral, emotional, and physical problems that arise with stress, there is a need for research that uses mind-body applications to support nursing students. At the end of the research, it is foreseen that the stress levels of nursing students and the symptoms seen due to stress can be reduced.

Method: The universe of the study will consist of 2nd, 3rd, and 4th year nursing undergraduate students who are studying and interning at Gülhane Nursing Faculty of Health Sciences University in 2022-2023. As a result of the power analysis, the minimum sample size was found to be 140 students, with 70 students in each group. During the study, in order to strengthen the results of the research and increase reliability, it was determined that the sample was 154 students with 77 experiments and 77 control groups with an increase of at least 10%. Student sampling; After each class is evaluated as a layer, proportional stratification will be taken by sampling method according to layer weight (number of students). 44 students from 2nd grade, 52 students from 3rd grade, and 58 students from 4th grade will participate in the research. Students have completed the Voluntary Consent Form for Nursing Students, Personal Information Form, Perceived Stress, and Bio-psycho-social Response Scale, then students who meet the inclusion criteria will be randomly assigned to intervention and control groups. Exercises will be applied to the intervention groups for 6 weeks. There will be no intervention in the control group. At the end of 6 weeks and 2 weeks after the last application (8. Weeks) intervention and control groups will refill the scales.
An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.
In the estrogen alone substudy of WHI, no overall effect on coronary heart disease (CHD) events (defined as nonfatal myocardial infarction [MI], silent MI, or CHD death) was reported in women receiving estrogen alone compared to placebo. (See CLINICAL STUDIES.)

In the estrogen plus progestin substudy of WHI, no statistically significant increase of CHD events was reported in women receiving CE/MPA compared to placebo (39 versus 33 per 10,000 women years). An increase in relative risk was demonstrated in year 1, and a trend toward decreasing relative risk was reported in years 2 through 5.

In postmenopausal women with documented heart disease (n = 2,763, average age 66.7 years), in a controlled clinical trial of secondary prevention of cardiovascular disease (Heart and Estrogen/progestin Replacement Study; HERS), treatment with daily CE 0.625 mg/MPA 2.5 mg demonstrated no cardiovascular benefit. During an average follow-up of 4.1 years, treatment with CE/MPA did not reduce the overall rate of CHD events in postmenopausal women with established coronary heart disease. There were more CHD events in the CE/MPA-treated group than in the placebo group in year one, but not during the subsequent years. Two thousand three hundred and twenty one (2,321) women from the original HERS trial agreed to participate in an open-label extension of HERS, HERS II. Average follow-up in HERS II was an additional 2.7 years, for a total of 6.8 years overall. Rates of CHD events were comparable among women in the CE/MPA group and the placebo group in the HERS, the HERS II, and overall.
The purpose of this research study is to find out if a hospital-based violence intervention (Bridging the Gap) is effective for reducing youth violence. Researchers think that youth who receive the Bridging the Gap will see greater improvements than youth who do not receive the intervention. Approximately 300 youth patients and 300 adult caregivers will enroll in this study. Participants will be randomized into a study group (either Bridging the Gap or Treatment as Usual). If patients agree to the study but do not like the group they are assigned to, they can request to switch groups. Participants assigned to the Treatment as Usual intervention will receive a brief violence awareness brochure during their hospital stay. Participants assigned to the Bridging the Gap intervention will receive an in-hospital intervention and, once released from the hospital, will receive 3-months of community case management services with their families. The study team thinks that youth who receive the Bridging the Gap intervention will see greater improvements than youth who do not receive the intervention. Participation in this study will last up to 6 months.
There are only about 100 case reports on the Acute Idiopathic Blind Spot Enlargement Syndrome (AIBSES). This is characterised by the eponymous visual field loss in the blind spot area, acute onset photopsia, and funduscopically little or no change in the optic disc area, with conspicuous outer retinal bands on optical coherence tomography (OCT). Typical is the unilateral occurrence. Predominantly young women are affected. While previous reviews of AIBSES either predate the introduction of OCT or focus on differentiation from potentially related outer retinal conditions (e.g., multiple evanescent white dot syndrome and acute zonal occult outer retinopathy), the present review will concentrate on the current perspective and treatment strategies that have been developed and will aim to help increase awareness. Since the first description of AIBSES in the late 1980s, the introduction of OCT has simplified the diagnosis and characterisation of AIBSES as a disease of the outer retina. Nevertheless, misdiagnosis remains common in the spectrum of optic neuritis, as AIBSES may be ignored in differential diagnosis.
The trial and recruitment will be conducted at the Queen Elizabeth National Spinal Injuries Unit (QENSIU), Glasgow. Individuals with tetraplegia and upper limb weakness will be randomly allocated to receive either a tailored progressive resistance training (PRT) programme alongside usual care or usual care alone.

Up to 30 participants admitted to the QENSIU will be recruited to the study. They will be randomised to the intervention or control group. The intervention group will receive 8 weeks of PRT. An upper limb functional goal will be identified through discussion with the researcher and the participant. PRT will be individually tailored to target two muscle groups which contribute to achieving this goal. For each muscle group 3 sets of 8-10 repetitions will be carried out, resistance will be applied using wrist weights, free weights or resistance bands as required. Measurements of muscle strength and function will be assessed prior to, and following the study. Outcome measures: Manual muscle testing, Handheld Dynamometry, The Spinal Cord Independence Measure, The Action Research Arm Test.
GROUP C: Treatment with Monotherapy. Chlorthalidone 12,5 mg. Once daily during 12 weeks.
A thromboplastin reagent comprises: (i) activated sTF, (ii) a metal-chelating lipid, (iii) a metal ion, and (iv) a phospholipid. Activated sTF preferably includes the extracellular domain of TF and an oligohistidine moiety having at least 2 histidine residues, more preferably 2-10 histidine residues. Preferably, the histidine residues are consecutive. Attaching a metal binding domain, such as an oligohistidine tag, to the C-terminus of sTF allows the protein to bind to phospholipid vesicles that contain metal -chelating lipid. Metal complexes of this activated sTF and metal-chelating lipids have all of the desirable expression, handling, and solubility characteristics of sTF, and exhibit procoagulant activities in plasma clotting tests that are comparable to relipidated rTF. In addition, it was discovered that, under some circumstances, Ni-lipids are themselves procoagulant, even in the absence of activated sTF. Further studies indicated that Ni-lipids are potent activators of the contact pathway of blood clotting.
Wet glass ionomer cement is applied to a tooth lesion. Before the cement hardens, wet amalgam is applied on top of the glass ionomer cement. The glass ionomer bonds to the tooth, and the interface of the wet cement and wet amalgam allows strong bonds to form between the glass ionomer cement and the amalgam, to provide an exceptionally strong bond between the amalgam and the tooth. Metal bases, metal salts and/or metal oxides are added to an amalgam restoration formula for use in conjunction with a glass ionomer cement to restore a tooth lesion. The additive is comprised of an amount of metal bases, metal salts and/or metal oxides, such as the powder of a polycarboxylate dental cement, sufficient to improve the bond strength between wet glass ionomer cement applied to the tooth lesion and the wet improved amalgam applied to the wet cement. As a result, the retentive quality of such a restoration is improved and therefore may permit a lesion to be filled with amalgam rather than requiring extraction or the application of a prosthesis.
Characteristics of electrograms depend on the electrode design and distance to the electric source. Our aim was to assess the impact of electrode design and distance from the myocardial electric source on the unipolar and bipolar electrograms to deduce a far-field cut-off. We retrospectively analyzed left atrial electroanatomical maps of 25 patients acquired using an ablation catheter with a 4.5 mm tip-, mini- and 2 mm ring electrodes. The unipolar and bipolar electrograms were characterized based on peak-to-peak amplitude, signal duration, maximal slope, and relative power of the high frequency spectrum above 50 Hz (HF_rel). The unipolar electrograms of ring electrodes showed an increased amplitude (140%), slope (150%) and HF_rel (16% vs. 11%) compared to the tip- and mini-electrodes. The median amplitude, slope, and HF_rel for the ring electrodes followed a power-law decay with distance with a steep decline up to 4 mm. This near-field cut-off can be identified based on a HF_rel above 10% in unipolar electrograms. In conclusion, we observed a higher unipolar amplitude for small ring-electrodes compared to larger tip-electrodes. The rapid decay of the amplitude, slope, and HF_rel up to a distance of 4 mm is suggestive for near-field cut-off identified based on HF_rel above 50 Hz.Clinical Trial Registration: NCT04095559.