anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A perfume composition with excellent preference and an external use skin composition containing the same are provided to ensure light and fresh feeling and to enhance preference. CONSTITUTION: A perfume composition which reproduces fruit perfume of oriental medicinal herb contains 45-60 wt% of perfume ingredient including 12-26 wt% of alpha-pinene, 10-22 wt% of caryophyllene, 10-22 wt% of hexanoic acid, and 6-14 wt% of D-limonene. The composition further contains 3-6 wt% of methyl heptenone. The composition also contains 3-6 wt% of linalool, 3-6 wt% of penthyl alcohol, rho-cymene, 2-5 wt% of citronellol, alpha-terpineol, 1-4 wt% of geraniol, 1-4 wt% of aldehyde C-9, and 1-4 wt% of amylvinyl carbinol. The fruit fragrance includes fragrance of Crataegi Fructus and Rubi Fructus. An external use skin composition contains the perfume composition.
The present invention discloses a yew health-care composite for reducing blood sugar, which uses yew tissue as a principal raw material. The present invention comprises roots, stems, leaves, stems and powder or granular materials of bark of the yew. The Ingredients of the composite and a weight percentage content comprise 50% to 95% of yew tissue, 3% to 25% of figwort and 2% to 25% of rehmannia root, and 5% to 7% of atractylodes of the total weight of the three is added. The composite can be drunk by soaking by boiled water or made into various beverages for drinking. The blood sugar can be averagely decreased by more than 2.7 mmol/l, and the effective rate is higher than 97%. The present invention achieves the purposes of making beverages by yew tissue and effectively reducing blood sugar. The present invention has the advantages of simple manufacture, convenient operation, wide range of application, good technical effects, etc. The present invention is widely suitable for various people to take for preventing and curing diabetes, and is especially suitable for diabetic to take for reducing blood sugar.
INTRODUCTION: There has been increasing concern about potential negative impact of mid-urethral slings (MUS) on sexual life. Our aim was to study sexual activity 10-20 years after MUS surgery and changes in impact of incontinence on sexual life over time and to compare subjective cure, pain, satisfaction, and incontinence between sexually active and inactive women 10-20 years after MUS.
MATERIAL AND METHODS: Historical cohort study using the Norwegian Female Incontinence Registry to identify women who underwent MUS between 2001-2006 and 2011-2012. They answered validated questionnaires about sexual activity, incontinence, pain, and satisfaction with MUS. We assessed changes in urinary incontinence during intercourse and compared symptoms and satisfaction between sexually active and inactive women. The study was registered in Clinical Trials (NCT04912830).
RESULTS: In total, 1210/1903 (64%) responded. Of women responding to questions about sexual activity, 63% (735/1166) were sexually active. 31.3% experienced negative impact of incontinence on sexual life preoperatively, decreasing to 5.9% at 10-20 years follow-up. A higher proportion of sexually inactive vs sexually active women had urinary incontinence (63.5% vs. 47.5%, aOR 1.60 [1.18-2.17]). In a subanalysis, only urgency and mixed urinary incontinence remained significant. A higher proportion of sexually inactive were dissatisfied with MUS (30.1% vs. 12.9%, aOR 2.53 [1.82-3.51]). Persistent pain after MUS was similar for sexually inactive and active women (4.0% vs. 3.2%, aOR 1.10 [0.55-2.19]). Furthermore, 3.4% of sexually inactive had persistent pain after MUS and stated pain as a reason for not being sexually active, whereas 1.7% of sexually active women had persistent pain after MUS and pain during intercourse.
CONCLUSIONS: Negative impact of incontinence on sexual life was less prevalent at 10-20 years follow-up after sling surgery compared to preoperative assessment. A higher proportion of sexually inactive had urgency and mixed urinary incontinence and were dissatisfied with MUS. Only 3%-4% of sexually active and inactive women had persistent pain after MUS and this was not associated with sexual activity. This indicates that incontinence has a greater negative impact on sexual activity than persisting pain after MUS at long-term follow-up.
The 7 units of curriculum fit in with the theory of planned behavior where the educational components of the BiC intervention are designed to impact knowledge, attitudes, norms, and perceived control over sexual health related outcomes (i.e., sexual intercourse and contraception usage), ultimately influencing intention and behavior. The curricula is trauma-informed and integrate a PYD approach through creation of safe environments, engagement of youth through creative activities, and facilitation of progressive skill-building.
In this group, patients will undergo the standard transumbilical laparoscopic appendectomy procedure through a 15 mm trocar port in the umbilical region. The procedure will involve locating the appendix and removing it via an extracorporeal approach.
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1 BB. The molecule may have at least one humanized 5T4 binding domain or a 4-1BB binding domain. The molecules are useful for treating cancer. The protein molecule that binds to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules can bind to both cells expressing 5T4 and cell surface molecules expressed by effector cells to enhance effector cell activation, proliferation, survival, and/or effector cell-mediated cytotoxicity. The present disclosure also provides pharmaceutical compositions comprising 5T 4-binding or 4-1 BB-binding polypeptide or protein molecules; nucleic acid molecules encoding these polypeptides; and methods of making and using these molecules.
BACKGROUND: Diagnosing parosmia is a challenge. The present study aimed to explore the distinctions between hyposmic patients with and without parosmia utilizing electroencephalography-derived olfactory event-related potentials (ERP).
METHODS: Forty-four patients with hyposmia were enrolled and divided into a group with parosmia (n = 23, mean age ± standard deviation = 48 ± 14 years, seven men) and a group without parosmia (n = 21, age = 52 ± 12 years, seven men) based on the clinical interview. Additionally, 21 healthy controls (mean age = 45 ± 14 years, six men) were included. Various measurements were obtained, including the Sniffin' Stick test, threshold tests for the odorants furfural mercaptan and 2,6-nonadienal, a modified Sniffin' Stick parosmia test, and well-being ratings. Chemosensory ERPs were recorded separately for each nostril using high-precision, computer-controlled air-dilution olfactometry.
RESULTS: Patients with parosmia had a decreased olfactory function similar to that observed in patients with hyposmia, although the odor sensitivity of patients with severe parosmia remained relatively unaffected. Patients with parosmia reported a decrease in well-being compared to controls. The severity of parosmia was positively correlated with odor sensitivity. Furthermore, patients with severe parosmia exhibited faster responses to unpleasant odors than patients without parosmia.
CONCLUSION: Overall, the present findings support the idea that parosmia predominantly occurs during olfactory recovery, significantly disturbing patients and warranting the development of effective treatments. Notably, the relatively faster responses of hyposmic patients with severe parosmia suggest that the generation of distorted olfactory responses may involve early stages of the processing of olfactory information.
Participants receive etoposide 100mg/m2 day1-3+carboplatin AUC 5 day 1(EC) combined with Adebrelimab（ PD-L1 inhibitor）1200mg day1 Q3w for 2 cycles, and the efficacy is evaluated 3 weeks after the treatment. If the efficacy evaluation is SD/PR/CR, concurrent radiotherapy(45Gy /3Gy/qd/3w) with EC(2 cycles) + Adebrelimab will be initiated. After concurrent chemoradiotherapy+ Adebrelimab, Adebrelimab was maintained until PD or intolerance or for at most 2 years.
Patients assigned to the study group will receive Ang 2 infusion in addition to standard vasopressor regimen. Ang 2 is currently approved at UCLA as a second line vasopressor and will be used as such for the purposes of our study. Hemodynamic goals will be established at the beginning of the case by the anesthesiology and surgical teams. Ang 2 will be started as a second vasopressor once the norepinephrine dose has reached 0.05mcg/kg/min. Ang 2 will be initiated at a starting dose of 5ng/kg/min. That dose will be up titrated one time to 10ng/kg/min as vasopressor requirements escalate. Once a patient is on the 10ng/kg/min dose of ang 2, no additional up titration will be performed. Hemodynamic management will continue throughout the case with titration of other vasopressors as needed. Ang 2 will be continued throughout the intraoperative period but will be weaned off prior to leaving the operating room.
Echocardiographic grades of diastolic function was defined according to 2016 ASE/EACVI recommendations for the evaluation of LV diastolic function. Cardiac diastolic dysfunction was defined as elevated E/e'≥15.
The invention relates to a bioactive chemical composition, more specifically to proteins and can be used in medicine, veterinary and cell biology. The inventive glycoproteins are extracted from an intercellular space of the tissue of various organs, blood serum and bile of vertebrates (human beings and animals). Said glycoproteins have a high biological activity in super low doses at a concentration ranging from 10-12 to 10-29 mol/liter and lower. It is thus possible to produce a pharmaceutical form including glycoprotein in an effective quantity and a pharmaceutically acceptable carrier. The glycoprotein protein produced finds application as a medicamentous form. 3 claims, 29 figures
Aim One: Determine mechanisms driving autonomic dysregulation of blood pressure (BP) in premature and early menopausal women. Because sympathetic activity and baroreflex function are important contributors for autonomic support of BP regulation, these two mechanisms will be assessed in premature and early menopausal women who are ≤49 yr old. To specifically identify the influence of menopause, these women will be compared to age-matched premenopausal women. The primary hypothesis is that there is greater resting sympathetic activity and blunted baroreflex function in premature and early menopausal women compared with age-matched premenopausal women. The secondary hypothesis is that BP and sympathetic reactivity will be greater in premature and early menopausal compared with age-matched premenopausal women when the sympathetic nervous system is challenged with a stressor.

Aim Two: Determine mechanisms driving autonomic dysregulation of BP in older menopausal women. Because older age contributes to risk of CVD, it is imperative to assess the long-term effects of premature and early menopause in older (≥50 yr) women. To determine the impact of the premature loss of sex hormones on cardiovascular physiology, women whom have lived without functioning ovaries for \>10 yr will be compared to age-matched women who entered menopause at a typical age. The primary hypothesis is that resting sympathetic activity is greater and baroreflex function is attenuated in women who experience premature or early menopause compared with typically-aged menopausal women. The secondary hypothesis is that BP and sympathetic reactivity will be greater in premature and early compared with typically-aged menopausal women when the sympathetic nervous system is challenged with a stressor.
Historical control group. Patients in this group are drawn from the same plan populations as the intervention group, but they are identified during the 1-year period prior to the start of patient enrollment in the intervention group. The historical control group is closely matched with the intervention group on demographic characteristics, practice patterns, and benefit plan features that may affect resource utilization.
The present invention relates to a Chinese traditional medicine preparation for treating asthma and cough and a preparation method thereof. The preparation is prepared from ephedra, bitter apricot seed, japanese ardisia herb, epimedium herb, etc. The preparation comprises capsule preparations, granule preparations, soft capsule preparations, tablet preparations, drop pill preparations, etc. The present invention also provides a preparation method thereof. Compared with the prior art, the present invention has simple preparation; produced products has high stability and convenient administration;. The preparation has good treatment effect on treating pathological symptoms of tissue, expectoration, asthma oppression in chest, soreness and weakness of waist and knees, etc.
Mineralocorticoid receptor antagonists (MRAs) are one of the renin-angiotensin-aldosterone system inhibitors widely used in clinical practice. While spironolactone and eplerenone have a long-standing profile in clinical medicine, finerenone is a novel agent within the MRA class. It has a higher specificity for mineralocorticoid receptors, eliciting less pronounced adverse effects. Although approved for clinical use in patients with chronic kidney disease and heart failure, intensive non-clinical research aims to further elucidate its mechanism of action, including dose-related selectivity. Within the field, animal models remain the gold standard for non-clinical testing of drug pharmacological and toxicological properties. Their role, however, has been challenged by recent advances in in vitro models, mainly through sophisticated analytical tools and developments in data analysis. Currently, in vitro models are gaining momentum as possible platforms for advanced pharmacological and pathophysiological studies. This article focuses on past, current, and possibly future in vitro cell models research with clinically relevant MRAs.
The invention relates to a long-acting benserazide sustained release microsphere composition. The composition comprises the following components in percentage by weight: 40 to 99 percent of degradable hydrophobic polymer and 1 to 60 percent of benserazide. The invention also provides a preparation method for the long-acting benserazide sustained release microsphere composition. The composition overcomes the defects of the conventional single oral administration scheme, administration loss of people with the disease due to the requirements of frequent oral administration, and ineffective treatment. The invention provides the preparation method using one W/O/W. The particle diameter of the composition can be controlled according to different needs and the composition does not pollute environment; and influences on the treatment effect of the benserazide can be avoided. The particle diameter can be adjusted and controlled to be between 1 mu n and 500 mu n according to needs. The freeze-drying powder of the composition is white, delicate and loose, does not collapse and conglutinate and has good dispersibility. Compared with an oral preparation of the same dosage, the composition is obviously better than the oral preparation in effect.
Although physical activity has been identified as a relevant determinant of cancer therapy outcome, its valid assessment remains challenging. In principle, direct and indirect assessment instruments can be employed for assessment of physical activity. While direct instruments, e.g. accelerometers, are considered to provide a more objective measurement, indirect tools such as questionnaires are less expensive and more applicable for use in larger study populations. The validity of both forms of measurements in cancer patients is however not well studied. Therefore, this study aims to elucidate the relative validity of an accelerometer in comparison to a standardized physical questionnaire at different time points of cancer therapy. Findings of this study will allow conclusions regarding the ideal modalities for assessment of physical activity in cancer patients.
In the active group, non-invasive transcutaneous magnetic stimulation of the dorsal spine will be applied by placing a circular magnetic coil (Magventure®️ MagPro®️ R20) on the skin, in the upper thoracic region (chest level T2-T3). The stimulation intensity will represent 100% of the motor threshold, this determined by abdominal muscle contractions, found from single pulses, applied gradually every 10 seconds until the contractions appear. The intermittent theta burst stimulation protocol will consist of 20 stimulation trains, with an interval of 8 seconds between trains, each train will have 20 bursts, and each burst will have 3 pulses at 50 Hz repeated at 5 Hz. In total, 1200 pulses will be applied for 3 minutes and 58 seconds.
Abstract Infant Formula With High Sn-2 Palmitate And Oligofructose An infant formula having a relatively high content of triglycerides having palmitic acid in the sn-2 position. The formula may include oligofructose. The formula may also include at least one omega 6 fatty acid and at least one omega 3 fatty acid. The formula may also have a relatively low protein content and an alpha-lactalbumin content similar to human milk. The invention also includes a method for improving the stool consistency, increasing bifidobacteria in the colon, and reducing calcium soaps in the stool of a formula-fed infant.A Most illustrative Figure: Fig. 1
Patients with post-stroke depression (PSD) have more dysfunction, poorer recovery outcomes, and higher morbidity and mortality in the first year after stroke onset than those patients without stroke. Some therapeutic methods have shown to be effective for PSD, including antidepressants, non-drug interventions, and combination therapies. However, pharmacological agents not only show unwanted side effects, including nausea, diarrhea, fatigue, and dizziness, but also produce high risk of hemorrhagic complications and stroke. Therefore, in addition to antidepressants treating PSD, non-drug interventions have been proposed to treat PSD. Until now, there are various physical techniques, including transcranial magnetic stimulation, vagus nerve stimulation, transcranial direct current stimulation, transcranial ultrasonic stimulation, etc. Previous studies have shown that transcranial alternating current stimulation (tACS) is commonly used to relieve pain, and has also been used to treat conditions such as transient tic disorder and cluster headaches. In the brain, there are specific opioid receptors which are not independent, and they work together with the electro analgesic system. Patients treated for chronic pain had lower levels of endorphins in their cerebrospinal fluid. Theoretically, using tACS can alleviate pain was caused by electrical stimulation to activate the brain's pain system (anti-nociceptive system), led to the beta-endorphin, serotonin and norepinephrine release.

Therefore, the study is expected to verify the effect of Transcranial Alternating Current Stimulation on patients with PSD in China and preliminarily explore the variations of gamma and beta-oscillations and cognitive function for the intervention of PSD utilized by it.
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia that leads to acute lung damage, deterioration of lung function, and increased mortality risk. In this study, we investigated the effects of the orange coproduct extract (OCE) and the combination of pure hesperidin and oleuropein (HO) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar rats. Rats were divided into six groups: the control group (G1), the BLM group (G2), three groups (G3, G4, G5) receiving a single dose of BLM combined with OCE extract at 100, 200, and 300 mg/kg, and group 6 (G6) receiving a single dose of BLM combined with HO: both pure major phenolic compounds of OCE (hesperidin at 50 mg/kg) and olive leaves (oleuropein at 2.5 mg/kg). Oxidative stress in lung tissues was investigated using catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) assays and the measurement of malondialdehyde (MDA) and lactate dehydrogenase (LDH) levels. Treatment with OCE and HO normalized the disturbance in oxidative markers' levels and showed a significant reduction in fibrosis score with no renal or hepatic toxic effects. In conclusion, OCE and HO exhibit antifibrotic effects on a rat model of pulmonary fibrosis.
Aim: This research was conducted with the purpose of determining the effect of biological nurturing technique used for starting breastfeeding in primipara on breastfeeding success and self-efficacy.

Material and Method: This randomized controlled study was conducted with 130 mothers who had a cesarean section in a public hospital located in Southeast Turkey (65 experimental, 65 control). The mothers in the control group received routine hospital care. The mothers in the experimental group were taught the biological nurturing technique after the first breastfeeding and breastfeeding was provided according to the technique during the hospitalization. Pre-test data were obtained by applying LATCH and BSES-SF to the mothers in the experimental and control groups at the 1st hour after the first breastfeeding. LATCH was re-administered at the end of the 8th and 24th hour postpartum. Post-test data were obtained by administering LATCH and BSES at the end of the 48th hour postpartum.In statistical analysis; count, percentage distribution, arithmetic average, chi-square test, standard deviation, t-test in dependent and independent groups and ANOVA analysis in repeated measurements were used.
PURPOSE: An anticancer drug composition including resveratrol derivative compound separated from grape stem shell is provided to prevent and treat all kinds of cancers including lung cancer, ovarian cancer, melanoma, central nervous system tumor, colon carcinoma, and leukemia. CONSTITUTION: An anticancer drug composition includes vitisinol C, vitisinol E, cis-vitisin A, vitisin B, vitisin C, a pharmaceutically acceptable salt and isomer or a mixture thererof, and grape stem shell extract including thereof as an active ingredient. The grape stem shell extract is obtained by extracting methanol, methanol aqueous solution, ethanol, ethanol aqueous solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma or colon carcinoma. A health enhancement food having cancer cell growth inhibition efficacy contains vitisinol C, vitisinol E, cis-viticin A, viticin B, viticin C, pharmaceutically acceptable salt, isomer or a mixture thereof, and grapes stem shell extract including the same. The food is in beverage form. The grape stem shell extract is obtained by the following steps: extracting the grape stem shell by methanol and suspending the obtained extract in distilled water; partitioning thereof by dichloromethane; and extracting the obtained water layer by ethyl acetate.
Participants will eat two whole eggs/day for 30 days. Participants will be given a specified number of Kieke eggs to last them until their next appointment. They will be asked to eat no other eggs than the eggs given to them and to return cartons with any leftover eggs.
Systems and methods for automatically staging non-small cell lung cancer are provided. Patient data relating to a cancer of a patient is received. The patient data comprises one or more medical images and one or more biopsy reports. A T-stage of the cancer is determined based on a location and a size of one or more tumors of the cancer determined using the patient data. An N-stage of the cancer is determined by combining a metastasis evaluation of the cancer to regional lymph nodes determined from the one or more medical images and a metastasis evaluation of the cancer in the regional lymph nodes determined from the one or more biopsy reports. An M-stage of the cancer is determined based on a metastasis evaluation of the cancer to anatomical structures based on the patient data. The T-stage, the N-stage, and the M-stage are output.