anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The genitourinary syndrome of menopause (GSM) is a physiological process that affects more than 50% of postmenopausal women. It is a new definition that defines lower genital and urinary tract symptoms due to decreased estrogen levels in the menopausal transition and postmenopausal period. At the anatomical and histological level, estrogens can determine retraction of the introitus, thinning and regression of the labia, prominence of the urethral meatus, thinning of the vaginal epithelium and lamina propria layers with decreased glycogen stores, reduction in the papillae, and vascularization. Common symptoms of GSM include vaginal burning, itching, dryness, decreased lubrication, irritation, and dyspareunia. It may also include urinary symptoms such as urgency and dysuria.

Vaginal moisturizers, continuous sexual activity and lubricants are recommended as first-line treatment by the North American Menopause Society and The Endocrine Society in the treatment of GSM. When these first-line treatments are inadequate, local estrogen therapy or selective estrogen receptor modulators may be considered for suitable candidates. According to the International Urogynecological Association document, low-dose vaginal estrogens resulted in a level of evidence 1 for safe and effective treatment of GSM symptoms. In the last few years, increasing research has focused on alternative treatments such as energy-based devices and the use of laser (i.e., fractional microablative CO2, Er:YAG laser) while various studies are reassuring about the side effects of these treatments, long-term side effects remain to be defined. Previous studies have shown that fractional carbon dioxide (CO2) laser is effective and safe in improving vaginal symptoms associated with GSM. The use of this device should be done safely by trained health professionals, with certified devices, in exact indications, ideal conditions according to contraindications. The aim of the study was to evaluate the efficacy of laser therapy with CO2 vaginal laser on GSM symptoms with a prospective approach based on quality of life questionnaires completed by treated patients.
The object of the invention is a pharmaceutic production, particularly for diagnosis of neoplasmas, based on the enclosed formula I. To the aqueous solution of potassium tetrachloroplatinate is added methionine by the molar relation of methionine to tetrachloroplatinate 2 to 1. The solution is mixed intensively. The aqueous solution of tetrachloroplatinate before the addition of methionine is enriched to a large concentration of chlo­rides, e.g. by the addition of sodium chloride and po­tassium chloride and pH of the mixture is brought to the value 3 to 5. Methionine is added to so prepared solution and in the course of further manufacturing pro­cess, to the complex of dichlorodimethionineplatinum is added metal salt. The components are mixed and pH of the solution is brought to the value about 6, 5. At last the solution is infiltrated through the sterile filter.
PURPOSE: To obtain a material which can be used for cosmetics, emulsion and deodorant and shows comfortable touch and is smoothly spread by using porous microspheres coated with perfluoride oil, fluorinated silicone oil or silicone rubber. CONSTITUTION: Porous microspheres having <800 μm average grain size and consisting of polyamide or the like are coated with perfluoride oil, fluorinated silicone oil or silicone rubber by 0.1 to 500 wt.% to the weight of the porous microspheres. The pores of the porous microspheres are filled with a hydrophilic phase (e.g. water) lipophilic phase (e.g. paraffin oil) or perfluoride phase (e.g. perfluoropolyether having <1000 mol.wt.) before coating. The obtd. porous microsphere can be used for lipsticks, cosmetic powder, eye shadow, powder blusher, mascara, foundation, creme, lotion, emulsion and deodorant.
Trachomatous scarring has been shown to progress regardless of active ocular Chlamydia trachomatis infection, indicating that scarring drivers may be unrelated to ongoing transmission. Although scarring prevalence is commonly associated with older age and female sex, less is known about other potential contributors to its development. This study identified and assessed risk factors associated with scarring magnitude in a trachoma-endemic setting, utilizing a five-point photographic scale (S0-S4). During 2017 trachoma surveys of Amhara, Ethiopia, photographers captured left and right conjunctival images of adults (ages 15 years and older) from 10 districts. Subsequently, two graders independently assessed photographs for scarring, with discrepancies adjudicated by an expert grader. Scarring scores for 729 individuals were aggregated from the eye level to the participant level, excluding 17 participants because of poor photograph quality. Among those with scarring, most cases (20.4%) were severe (S4, comprising more than 90% of the tarsal conjunctiva) compared with the prevalence of moderate S3-A/B (11.2%), S2 (8.3%), and mild S1 (19.2%). The youngest group (ages 15-19 years) exhibited all scarring stages. Older participants (60 years and older) experienced a greater burden of severe scarring (S4 prevalence: 32.6%) than their younger (15-19 years) counterparts (6.2%). Multivariate ordinal logistic regression models indicated female sex, increasing age, and district-level trachomatous follicular-inflammation prevalence were significant predictors of scarring severity. Trachomatous scarring and its progression to trichiasis, may prove a barrier to meeting WHO timelines for trachoma elimination and will necessitate ongoing surveillance and interventions after elimination thresholds have been met.
Adenomas are polyps of the colorectum that have the potential to develop into colon cancer \[1\]. However, some adenomas never become malignant and if they do, progression from adenoma into cancer usually takes a long time. As a result, screening colonoscopy programs were established in order to detect and resect adenomas at an early stage \[2\]. After resection, polyps should be sent to pathology in order to make a histological diagnosis. Not every colorectal polyp has adenomatous histology. Approximately 40-50% of all polyps contain other benign histology (e.g. hyperplastic or inflammatory polyps). These polyps do not bear the risk of colon cancer.

The implementation of screening programs has led to increasing numbers of colonoscopies in the last years \[3\]. This approach naturally implies higher amounts of detected polyps. The removal of these polyps and consultation of a pathologist in order to make a diagnosis is time consuming and expensive. An optical- based prediction of polyp histology (adenomatous versus non- adenomatous) would enable endoscopists to save money and to inform patients faster about examination results. The approach of predicting polyp histology on the basis of optical features is called the "optical biopsy" method. The prediction is made by the endoscopists during real-time colonoscopy. The aim of this strategy is to make an optical diagnosis which enables users to resect polyps without sending the specimen to pathology. Narrow Band Imaging (NBI) is a light-filter device which can be switched on during colonoscopy. NBI is useful to better display vascular patterns of the colon mucosa. It has been shown that the use of NBI can facilitate optical classification of colorectal polyps \[5\]. A NBI- based classification schemes exists which can be used to assign polyps into specific polyp categories (adenomatous versus non- adenomatous) \[6\].

Prior to the implementation of the optical classification approach for routine use in endoscopy it is necessary to proof its feasibility and accuracy \[7\]. Otherwise the approach would entail the risk of wrong diagnoses which could lead to wrong recommendations on further diagnostic or therapeutic steps.

Until now, some clinical trials have shown good accuracy for the optical biopsy method \[5\]. However, there is growing evidence that optical biopsy does not yet meet demanded accuracy thresholds \[8\]. The aim of our study is to create a computer program that is able to distinguish between adenomatous and non-adenomatous polyps. Still images of colorectal polyps including NBI- pictures of polyps will be used for machine learning (validation phase). Afterwards a set of 100 still pictures will be used to test whether the computer program is able to distinguish between adenomatous and non- adenomatous polyps (primary endpoint). Statistical measures (accuracy, sensitivity, specificity) will be calculated.
Internet-based cognitive-behavioral therapy (iCBT) is an effective treatment for social anxiety disorder (SAD). However, little is known about the processes and mechanisms of change in this treatment. Compared to face to face (FTF) treatments, online interventions may operate through partially different mechanisms of change due to the text-based nature of the interaction and the reduced level of therapist involvement. The present randomized controlled trial will examine therapeutic processes during iCBT for SAD including the presence of sudden gains and their relationship to outcome, the relationship between anxiety and depressive symptoms along the course of treatment, changes in the therapeutic alliance and attrition from therapy. Moreover, we will compare iCBT for SAD with a wait-list control group and utilize weekly measurements of anxiety, depression, and SAD-related cognitions in both groups. This will facilitate comparison between temporal processes in both conditions and also shed light on processes occurring in wait-list conditions.
Systems and methods for non-vascular sensor implantation and for accurately measuring a physiological parameter in areas of a body where amounts of the physiological parameter are heterogeneous. An implant unit (10) is implanted in an area of a body and a foreign body capsule is allowed to form around the area of the implant unit. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area of the body. A subcutaneous area of the body may be tunneled to place the sensor. A plurality of spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area may be determined based on the sensed amounts.
PURPOSE:To form the hybrid antibody having the power to recognize two antigens by polymerizing two kinds of antibody molecules having the antigen specificity different from each other by a crosslinking structure via the carboxyl groups of the respective antibody molecules. CONSTITUTION:Two kinds of the monomer type antibodies are dissolved in a suitable buffer soln. and after a condensing agent is added to this soln., diamine is added thereto to effect a crosslinking reaction and to polymerize two kinds of the above-mentioned antibody molecules by the crosslinking structure via the carboxyl groups of the respective antibody molecules. The hybrid antibody obtd. in such a manner is the polymer type hybrid antibody covalent- bonded with diamine as a spacer. The novel type of the hybrid antibody having the polymerized structure via the carboxyl groups is obtd. in this way.
The study would have 2 stages. In the first stage, around 12 healthy adults aged 18-45 (male vs female,around 1:1)would receive 135μg/0.5ml of the HPV vaccine, the participants would be actively followed up for 7 days, if no vaccine related serious adverse events(SAE) occurred and the vaccine is well tolerated, another group of 12 healthy adults aged 18-45 (male vs female,around 1:1)would be enrolled and would receive 270μg/0.5ml of the HPV vaccine. The vaccine would be administered intramuscularly at day 0, month 1 and month 6. All the participants would be actively monitored for adverse reactions/events for 1 month after each injection. SAE during the trial were followed up. And blood, liver and kidney function changes will be monitored before and 2 days after the first and third vaccination. Serum samples from all the subjects would be collected on day 0 and month 7 to test immunogenicity as exploratory analysis.
All subjects are tested three times, each in a different diet-induced metabolic state: glycolytic (glucose burning), fasting (8 hours no food), and ketotic (fat burning). While having their brains scanned with MRI, subjects are initially tested at rest, and then perform a task. Midway through the session, subjects are removed from the scanner and drink up to 75g glucose. Our data analyses quantify network reorganization in response to changing energy constraints (i.e., cognitive demand, fuel).
Achieved formalin-fixed paraffin embedded tissue specimens from colon cancers and/or other benign and pre-cancer colon lesions as well as melanoma and/or other benign pigmented skin lesions will be used. The achieved specimens were kept in Department of Pathology, National Taiwan University Hospital. Sections of achieved pathological specimens were put on glass slides and tissue image will be observed by 3D optical coherence tomography (OCT). The 3D optic tomography system utilize a Ce:YAG optical fiber as light source and also combined with confocal microscopy. Taken together, these features made the 3D optic tomography system have very high resolution and suitable for single cell imaging. This study will not interfere with the normal medical practice and had no impact on patient's safety and health. All of the materials will be destroyed once the experiments are done. The enrollment criteria will be patients who underwent colon/skin surgery or examinations in NTUH with pathological specimens taken and stored at NTUH.
Disclosed and claimed are recombinants or vectors including at least one nucleotide sequence encoding an immunogen or epitope or epitopic region thereof of avian leukosis virus of subgroup J, such as a recombinant MDV; for instance, a recombinant HVT. The recombinant or vector can express the immunogen, epitope or epitopic region; and, the immunogen can be the Env glycoprotein (gp85 and gp37) and/or the gag/pol proteins. The nucleotide sequence can be in the BamHI I or M fragment of the HVT genome; for instance in one of intergenic zones 1, 2, and 3 or in ORF UL55 or in ORF UL43. The nucleotide sequence can be under the control of a promoter such as a CMV-IE promoter. The recombinant can include at least one additional nucleotide sequence coding for an immunogen or epitope or epitopic region thereof of another avian leukosis of subgroup J and/or another avian pathogen. The recombinant can also include a nucleotide sequence encoding an immunomodulator such as an avian cytokine. Immunogenic, immunological or vaccine compositions containing inventive recombinants, as well as methods  for immunizing fowl or for inducing an immunological response in birds, are also disclosed and claimed; and, kits for preparing such compositions are also envisioned.
Despite advances in intubation technology, difficult airways persist. Because it is failure to oxygenate, not failure to intubate, that ultimately leads to brain injury and cardiovascular collapse, effective mask ventilation is at least as important as successful intubation. Therefore optimizing mask ventilation is crucial for clinicians. When difficult mask ventilation encounters, clinicians often switch to two hand technique to hold the mask including either "C-E" clamp or "V-E" clamp. Both volume mode ventilation and pressure mode ventilation are superior with the V-E technique as compared to the C-E technique. The study will test the hypothesis that a novel reversal V-E mask ventilation technique will retain its high efficiency as that of standard V-E technique but be easier to use than standard V-E technique.
Participants randomized to the control group will receive diet and exercise counseling at baseline and 9 months. Participants will wear an ActivePAL for 7 days at baseline, 9 months, and 18 months without stimulation.
A key step in drug discovery, common to many disease areas, is preclinical demonstration of efficacy in a mouse model of disease. However, this demonstration and its translation to the clinic can be impeded by mouse-specific pathways of drug metabolism. Here, we show that a mouse line extensively humanized for the cytochrome P450 gene superfamily ("8HUM") can circumvent these problems. The pharmacokinetics, metabolite profiles, and magnitude of drug-drug interactions of a test set of approved medicines were in much closer alignment with clinical observations than in wild-type mice. Infection with Mycobacterium tuberculosis, Leishmania donovani, and Trypanosoma cruzi was well tolerated in 8HUM, permitting efficacy assessment. During such assessments, mouse-specific metabolic liabilities were bypassed while the impact of clinically relevant active metabolites and DDI on efficacy were well captured. Removal of species differences in metabolism by replacement of wild-type mice with 8HUM therefore reduces compound attrition while improving clinical translation, accelerating drug discovery.
PURPOSE: A pharmaceutical composition containing Polygonum multiflorum extract for lowering blood pressure is provided to prevent and treat hypertension. CONSTITUTION: A pharmaceutical composition for reducing blood pressure contains Polygonum multiflorum ethanol extract as an active ingredient. The ethanol is 70-90% ethanol. A functional food with an activity of reducing blood pressure contains Polygonum multiflorum ethanol extract as an active ingredient. A pharmaceutical composition for reducing blood pressure contains 0.02-50 wt% of the Polygonum multiflorum extract. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, external use formulation, and suppository.
The is an open-label study. Children diagnosed with ADHD will be provided with a weight-based dose of a chewable natural health product containing zinc, magnesium, vitamin B6 and vitamin C for 10 weeks with an additional follow-up post intervention at 20 weeks. Severity of ADHD symptoms will be measured at baseline, week 5 and week 10 using the Connor-3 Parent and SNAP-IV validated questionnaires. Nutritional status will be monitored at baseline and week 10 for changes in serum zinc and erythrocyte magnesium. Children will be monitored for any adverse reactions that may occur using the investigational product.Following the informed consent process, participants will undergo a structured psychiatric interview prior to enrollment and will have 4 30 minute study visits and 2 10 minute telephone calls throughout the study. Blood samples will be taken 2 times with the use of a topical anesthetic to decrease sensation during the blood draw. Once enrolled, children can withdraw from the study at any time if assent to participate is withdrawn.
PURPOSE:To obtain the subject inhibitor specifically acting on dental caries- inducing bacteria and keeping the colony phase balance for the indigenous bacteria living in the oral cavity. CONSTITUTION:This proliferation inhibitor contains >=0.0004 (pref. <=0.1)wt.% of chitosan derived from squid soft bone. The average molecular weight of the chitosan, is pref. >=9600 to <600000 and is obtained by acid or alkali treatment of the chitosan having normally >=600000 average molecular weight, derived from squid soft bone, to effect its molecular weight reduction. The deacetylation rate of the chitosan to be used is pref. >=80%.
The invention is a kind of fuzhiqing soft paste and the manufacturing method. It is made up by crushing jinguolan, rhubarb, ardisia crenata, mother chrysanthemum, viola yedoensis, hemsleya chinensis, kuh-seng, borneol, pairs polyphylla, mint brain and blending them with the cream base material. Compared with current technology, the construction of the invention is simple, the cost is low. It has functions of clearing away heat and detoxicating, dispersing blood stasis and promoting the subsidence of swelling, desiccation and relieving itching. It is tested that the invention has prominent effect on tinea manuum and pedis, tinea corporis, tinea cruris, jinying tumefaction, hemorrhoids, bleeding, and so on. It is quick-acting and it has no toxic side effect.
Mirazid is an antischistosomal drug available in the local Egyptian market since 2001 (Mirazid®). It originates from Myrrh a medicinal herb that has been used for thousands of years. Myrrh (Arabian or Somali Myrrh) is an oleo-gum resin, obtained from the stem of various species of Commiphora (Burseraceae) growing in northeast Africa and Arabia.
OBJECTIVES: Knee osteoarthritis (KOA) pain is caused by nociceptors, which are actually sensory nerve fiber endings that can detect stimuli to produce and transmit pain signals, and high levels of NGF in synovial tissue led to peripheral hyperalgesia in KOA. The purpose of this study is to investigate how sensory nerve fibers respond to the NGF/TrKA signal pathway and mediate the peripheral hyperalgesia in KOA rats.
METHODS: Forty SD male rats were randomly divided into 4 groups: normal, KOA, KOA + NGF, and KOA + siRNA TrKA. KOA model rats were induced by anterior cruciate ligament transection (ACLT). Mechanical and cold withdrawal thresholds (MWT and CWT) were measured 4 times in each group. The synovial tissues were harvested on day 28, and the expressions of NGF, TrKA, TRPV1, IL-1β, and PGP9.5 were determined using western blot, qPCR, and immunofluorescence staining. The primary rat fibroblast-like synoviocytes (FLSs) and DRG cells were divided into 4 groups as in vivo. The expressions of NGF, TrKA, TRPV1, and CGRP in vitro were determined using western blot and qPCR.
RESULTS: KOA and intra-articular injection with NGF protein increased both mRNA and protein levels, not only TRPV1, PGP 9.5, and IL-1β in the synovial tissue, but also TRPV1, PGP 9.5, and S100 in the DRG tissue, while above changes were partly reversed after siRNA TrKA intervention. Besides, siRNA TrKA could improve peripheral hyperalgesia and decreased the TRPV1 positive nerve fiber innervation in synovial tissue. The results in vitro were consistent with those in vivo.
CONCLUSION: This study showed the activation of the NGF/TrKA signaling pathway in KOA promoted the release of pain mediators, increased the innervation of sensory nerve fibers in the synovium, and worsened peripheral hyperalgesia. It also showed increased TRPV1 positive sensory innervation in KOA was mediated by NGF/TrKA signaling and exacerbated peripheral hyperalgesia.