anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Background/Objectives: Positive body image is linked to improved mental and physical well-being, healthier lifestyles, and fewer unhealthy weight control behaviors. Cultural factors also play a role in influencing body appreciation. This study investigated the associations between body appreciation, body weight, lifestyle factors, and subjective health among bachelor's students in Lithuania and Poland. Methods: A cross-sectional online survey was conducted with 1290 students from universities in both countries. The Body Appreciation Scale-2 (BAS-2) measured body appreciation, while participants provided self-reported data on their dietary habits, physical activity, sleep, health perceptions, and body weight and height. Linear regression models explored associations between BAS-2 scores, actual and perceived body weight, lifestyle habits, and subjective health. Results: Gender and country-based differences in body appreciation were observed. Lithuanian female students reported a higher median BAS score of 33 compared to 32 among Polish female students (p = 0.02), despite having a higher median BMI (22.3 kg/m2 vs. 21.1 kg/m2, p = 0.001). Positive body appreciation was linked to healthier dietary behaviors, such as higher consumption of fruits, vegetables, fish, and regular breakfasts. Additionally, greater physical activity and sufficient sleep were associated with higher body appreciation, while higher intake of sweets, sugary drinks, and fast food correlated with lower BAS-2 scores. Both BMI and perceived weight were negatively associated with body appreciation, particularly among females. Conclusions: Body appreciation is closely linked to body weight, healthier lifestyle, and positive health perceptions, suggesting that promoting healthier habits may improve body appreciation.
Ethyl acrylate is polymerized in aqueous suspension with benzoyl peroxide catalyst and in the presence of a -alumina particles and the polymeric suspension is treated with an aqueous mixture of FeSO4 and Na4P2O7 to form polyacrylate granules having alumina particles embedded therein.ALSO:A polishing agent suitable for use in a dentifrice comprises carrier particles of a material having a Moh's hardness less than 6 and an average size in the range 1 to 50 microns, the said carrier particles having embedded therein abrasive particles of a material having a Moh's hardness greater than that of the material of the carrier particles and an average size of less than 1 micron.  Suitable carrier materials are plastics materials, e.g. natural and synthetic rubbers, polyolefines, poyvinyl chloride and co-polymers of vinyl chloride and other unsaturated monomers such as vinyl acetate or vinylidene chloride, nylons, polyacrylates and polymethacrylates.  The abrasive materials may be aluminas, natural or synthetic silicas, calcium phosphates such as b -tricalcium or thophosphate, and thermosetting resins such as urea-formaldehyde or melamine-formaldehyde resins.  Optional ingredients in the dentifrice may be soap or synthetic detergents, flavouring materials, buffers, sweeteners, colouring materials and therapentic materials, e.g. sodium fluoride, stannous fluoride and sodium monofluorophosphate. The dentifrice may contain conventional carriers and abrasives, as well as particles of a plastics material not impregnated with abrasive particles.
The invention provides a carbon quantum dot and a preparation method and application thereof. The carbon quantum dot is synthesized by taking ethylenediamine and aspirin as raw materials and utilizing a hydrothermal method; the particle size of the carbon quantum dots is about 4-7nm, and the carbon quantum dots have photoluminescence characteristics under in vitro conditions. The carbon quantum dots proved to be effective in scavenging hydroxyl radicals and ABTS radicals present in the solution. In addition, they also exhibit a specific effect on Fe in solution  2+  And Fe (Fe)  3+  Chelating and scavenging capabilities of ions. Its preparation methodThe method comprises the following steps: and (3) carbonizing and condensing ethylenediamine and aspirin under high temperature and high pressure by utilizing a hydrothermal synthesis method. The method is simple and easy to operate, low in cost and convenient for mass production. The obtained carbon quantum dot has the characteristics of small size, easy water dissolution, high-efficiency oxidation resistance, iron chelating property and the like, and has potential medical value.
BACKGROUND: Subclinical thyroid diseases are often the subject of debate concerning their clinical significance, the appropriateness of diagnostic testing, and possible treatment. This systematic review addresses the variation in international guidelines for subclinical hyperthyroidism, focusing on diagnostic workup, treatment, and follow-up recommendations.
METHODS: Following the PRISMA guidelines, we searched PubMed, Embase, and guideline-specific databases and included clinical practice guidelines with recommendations on subclinical hyperthyroidism. Guideline recommendations were extracted, and quality assessment was performed using selected questions of the Appraisal of Guidelines for Research & Evaluation (AGREE) II instrument.
RESULTS: Of the 2624 records screened, 22 guidelines were included, which were published between 2007 and 2021. Guideline quality was generally intermediate to low. Diagnostic approaches differed substantially, particularly in the extent of recommended testing. Treatment initiation depended on TSH levels, age, and comorbidities, but the level of detail regarding defining precise comorbidities varied. Recommendations for monitoring intervals for follow-up ranged from 3 to 12 months.
CONCLUSION: This review underscores the existing variability in (inter)national guidelines concerning subclinical hyperthyroidism. There isa need for clear recommendations in guidelines considering diagnostic workup, treatment, and follow-up of subclinical hyperthyroidism. In order to establish this, future research should focus on determining clear and evidence-based intervention thresholds.
This arm will receive semaglutide (n=23). All participants will initially receive 0.25mg for 4 weeks, and then as tolerated dose will be increased to 0.5mg for 4 weeks. Then as tolerated, the dose will be increased to 1.0mg for 4 weeks.
Nonalcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation that can progress to inflammation (nonalcoholic steatohepatitis, NASH), and fibrosis. Serum β-hydroxybutyrate (β-HB), a product of the ketogenic pathway, is commonly used as a surrogate marker for hepatic fatty acid oxidation (FAO). However, it remains uncertain whether this relationship holds true in the context of NAFLD in humans. We compared fasting serum β-HB levels with direct measurement of liver mitochondrial palmitate oxidation in humans stratified based on NAFLD severity (n = 142). Patients were stratified based on NAFLD activity score (NAS): NAS = 0 (no disease), NAS = 1-2 (mild), NAS = 3-4 (moderate), and NAS ≥ 5 (advanced). Moderate and advanced NAFLD is associated with reductions in liver 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), serum β-HB, but not 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL) mRNA, relative to no disease. Worsening liver mitochondrial complete palmitate oxidation corresponded with lower HMGCS2 mRNA but not total (complete + incomplete) palmitate oxidation. Interestingly, we found that liver HMGCS2 mRNA and serum β-HB correlated with liver mitochondrial β-hydroxyacyl-CoA dehydrogenase (β-HAD) activity and CPT1A mRNA. Also, lower mitochondrial mass and markers of mitochondrial turnover positively correlated with lower HMGCS2 in the liver. These data suggest that liver ketogenesis and FAO occur at comparable rates in individuals with NAFLD. Our findings support the utility of serum β-HB to serve as a marker of liver injury and hepatic FAO in the context of NAFLD.NEW & NOTEWORTHY Serum β-hydroxybutyrate (β-HB) is frequently utilized as a surrogate marker for hepatic fatty acid oxidation; however, few studies have investigated this relationship during states of liver disease. We found that the progression of nonalcoholic fatty liver disease (NAFLD) is associated with reductions in circulating β-HB and liver 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2). As well, decreased rates of hepatic fatty acid oxidation correlated with liver HMGCS2 mRNA and serum β-HB. Our work supports serum β-HB as a potential marker for hepatic fatty acid oxidation and liver injury during NAFLD.
The invention discloses a peony gel patch with functions of relieving pain and removing blood stasis and a preparation method thereof, and particularly relates to the field of efficacy patches, wherein the peony gel patch comprises the following components: gel matrix, emulsifier and efficacy drug; the mass ratio of the gel matrix to the emulsifier to the effective medicine is 3: 1: 2-5; the functional medicine comprises, by weight, 20-40 parts of peony extract, 15-30 parts of herba euphorbiae ebracteolatae extract, 10-20 parts of rhizoma tuberosi extract and 5-10 parts of safflower extract. Wherein the peony extract contains various anti-inflammatory and analgesic effective components. The herba euphorbiae antiquorum extract has the effects of relieving swelling and pain, and can effectively relieve local joint swelling and pain after trauma. In addition, the rhizoma tuberosi extract and the safflower extract have the effects of relieving pain and removing blood stasis. The arthralgia can be relieved more effectively by the proportion of the four components. The gel matrix is used for wrapping the efficacy medicine, so that the acting time of the efficacy medicine can be prolonged, and the wound can be protected from being infected by external microorganisms.
Individuals with diabetes in the intervention 1 group will be interviewed for 'life coaching with diabetes'. Coaching is a set of systems that make people think deeply and reveal their own awareness and potential. A coach is a person who deliberately applies all these systems with awareness. Life coaching sessions with diabetes are based on the philosophy of coaching. Sessions are continued with questions that will enable the individual to realize the deficiencies in diabetes self-management. It helps the person with diabetes to discover solutions.This training will last for 3 months, once in 10 days. A total of 9 interviews will be provided.
A method, apparatus and system for use in treating a patient receiving an antineoplastic drug to optimize therapy and prevent an adverse drug response.  This system employs surrogate markers or indicators including blood levels of the antineoplastic drug to determine the next required dose for a patient. Since the surrogate markers are employed as a percent change in status, virtually any indicator can be used. Surrogate markers could include any measure of the effectiveness of the antineoplastic drug's action. Given the effectiveness of the antineoplastic drug's action relative to the surrogate markers, a change in antineoplastic drug dose is calculated by the system. Conversely, by employing this system, one could determine the expected result of the antineoplastic drug dose change on the surrogate markers.
Plasma Exchange will be performed for consecutive days. Standard medical therapy included as per requirement,management of cerebral edema/intracranial hypertension: transfer to ICU,prophylactic antibiotics, intubation of trachea (as required),administration of mannitol or 3% saline for severe elevation of Intra Cranial Pressure,volume replacement and pressor support (norepinephrine, vasopressin) as needed, NAC, correction of metabolic parameters and nutrition.
The system includes automatic physiological parameter measuring apparatus (20). The data is automatically transmitted and processed with the measuring apparatus automatically connected (30) to an information server (10) via a switched telephone network (14) and a digital transmission network (12). The server identifies the connected apparatus.  The storage, processing and information terminal connection are installed on the doctor's premises. The doctor's terminal can transmit at regular intervals or immediately in an emergency. A central monitor unit checks and coordinates activities and sends out prescriptions. Monitor times are adjusted to the patients needs.
OBJECTIVE: Primary aortoenteric fistulas (PAEFs) are a rare entity with high morbidity, and their relationship with Bacillus Instillation of Calmette-Guérin is anecdotal.
METHODS/RESULTS: We present a 68-year-old male with a primary aortoenteric fistula after instillation of Bacillus Calmette-Guérin (BCG) for a non-muscle-invasive bladder cancer. Diagnosis was made by CT angiography, subsequently confirmed by intraoperative findings and results of anatomopathological studies of aortic wall samples. We performed an in-situ reconstruction with a silver prosthesis impregnated in rifampicin with satisfactory evolution at one year.
CONCLUSIONS: Primary aortoenteric fistula is an extremely rare complication, and although its relationship with intravesical BCG therapy is anecdotal, it should be considered in patients with gastrointestinal bleeding who have previously undergone this treatment. Its diagnosis requires clinical suspicion, and its treatment should be carried out without delay. Long-term targeted anti-biotherapeutic treatment is a fundamental pillar for its management. Reconstruction with an antibiotic-impregnated silver prosthesis is a valid option in cases of controlled infection.
In a first aspect the present invention provides a method for producing an adoptive immune response to a target cell in a subject, said method including the steps of engineering a CD4+ T cell and engineering a CD8+ T cell to express a molecule capable of binding to an antigen on the target cell, and administering an effective number of the engineered CD4+ and CD8+ T cells to the subject. According to this method the CD4+ T cell and the CD8+ T cell are obtained from the subject, engineered, and re-administered to the subject to produce the adoptive immune response Applicants have found that in adoptive transfer experiments in vivo, administration of sufficient numbers of antigen engineered CD4+ in combination with engineered CD8+ cells leads to a significantly enhanced immune response to a target cell. It is demonstrated herein that the injection of CD4+ and CD8+ T cells engineered to express a molecule capable of binding to a tumor associated antigen led to significant improvement in survival of subjects having established lung metastases, compared with transfer of unfractionated spleen-derived (largely CD8+) engineered T cells. Importantly, anti-tumor responses in the subjects correlated with persistence and localization of engineered T cells at the tumor site and in the blood and spleen. Applicants have further demonstrated herein that subjects treated with engineered CD4+ and CD8+ T cells that survived primary tumor challenge could reject a subsequent rechallenge with the same tumor. The studies disclosed herein demonstrate the therapeutic advantage in the combined transfer of antigen-specific gene-modified CD4+ and CD8+ T cells to significantly enhance T cell adoptive strategies for the treatment conditions such as cancer and infectious diseases.
Women with recurrent BV use the Flourish HEC Vaginal Care System, consisting of three components: 1) "Balance" external wash; 2) BioNourish vaginal moisturizing gel (an FDA 510k cleared class II medical device); and 3) BiopHresh homeopathic vaginal suppository with probiotics. All system components are currently available to the public at national retailers. Women will use the system for six months. They will have vaginal microbiome composition (next-generation sequencing and Nugent score) and vaginal pH tested at baseline, 3 months, and 6 months. At each timepoint they will also complete the vulvovaginal symptoms questionnaire (VSQ).
Non-suicidal self-injury (NSSI), deliberate harm to the body without suicidal intent, is highly prevalent in young adults, with 1 in 10 college students engaging in over 100 episodes in their lifetimes. Consequences of NSSI are severe, including physical injury ranging in medical severity, distress from shame associated with the behavior, social isolation, psychological symptoms, and increased risk and lethality of NSSI over time. Despite the prevalence and significant consequences of NSSI, no empirically supported treatments specific to NSSI exist. The purpose of this study is to develop, implement, and evaluate an intervention specifically for NSSI in young adults, the Treatment for Self-Injurious Behaviors (T-SIB). This time-limited intervention will integrate theoretically-based strategies whose utility has been identified through empirical research with the goal of reducing frequency and severity of NSSI. The research plan consists of 2 phases. During Phase 1, 12 patients will be treated in an open pilot trial. During Phase 2, 60 patients will be treated in a randomized controlled pilot study to determine the feasibility and acceptability of T-SIB, investigate change in NSSI frequency and severity between T-SIB and treatment as usual (TAU) through a 3-month follow up period, and evaluate the research design of the randomized controlled pilot study to inform both the utility and design of a larger randomized clinical trial.
AZD9291(80mg, QD, p.o.) was provided to patients with confirmed EGFR T790M positive NSCLC who have received prior therapy with an EGFR-TKI and concurrent with brain metastasis. Radiation therapy will be implemented according to investigator's clinical practice(A 7-10 days washout period before radiotherapy and 1 week period after completion of brain radiothearpy before re-starting AZD9291.).
The newborns in the experimental group listened to the recorded heart sounds of their mothers for 1 minute before the heel blood procedure, during the procedure and for 1 minute after the procedure. At the same time, the behaviors of newborns were recorded on camera throughout the procedure. At the end of the study, the camera recording was monitored and scored by two midwives trained in the Neonatal Pain Scale.
FIELD: dentistry.SUBSTANCE: present invention relates to a new cleaning composition for dental prostheses, in particular, to an alcohol-free composition. The present invention also relates to a towel for a dental prosthesis, impregnated with the cleaning composition, and to an application thereof for cleaning removable dental prostheses. Described is a cleaning composition for dental prostheses, containing: (a) 3 to 15% wt./wt. of isopropyl ether of a fatty acid, selected from isopropyl palmitate, isopropyl myristate, and combinations thereof; (b) 0.5 to 4% wt./wt. of sorbitan polyoxyethylene ester, and (c) 0.5 to 4% wt./wt. of a second sorbitan ester selected from sorbitan monostearate, sorbitan monolaurate, sorbitan palmiate and combinations thereof; wherein the cleaning composition comprises 0.7 to 12% wt./ wt. of propylene glycol and 85 to 90% wt./wt. of water and does not contain methyl, ethyl or isopropyl alcohol.EFFECT: composition according to the present invention provides good cleaning of dental prostheses and significant removal of microorganisms while minimising damage to the dental prosthesis.7 cl, 8 ex, 2 tbl
DCB was used for post-dilation after stent placement. The DCB for post-dilation in this study is Orchid 035 DCB Catheter.
Participants will receive increasing doses of BT7480. It is expected that approximately 80 patients will participate in this dose escalation arm.
Oocytes treated with a ready-to-use ionophore compound (GM508 CultActive, Gynemed) within 15 min after ICSI (or 18 min in IVF). After 15 min of incubation in GM508 CultActive and a thorough washing process, the oocytes subjected to AOA will transfer to the same time-lapse culture dish with the controlled sibling group.
NEW MATERIAL:The compound of formulaI[R<1> and R<2> are alkyl which may be substituted with indolyl; Y is substituted aryl or (substituted) ar-lower-  alkenyl; Z is H, salt-forming cation, or carboxyl-protecting group]. EXAMPLE:N-[N-(3,4,5-Trihydroxybenzoyl)-(L)-leucyl]-(L)-leucine. USE:An agent for suppressing the secretion of gasrric juice. It has no side effect caused by anticholinergic action and has extremely high safety. PROCESS:The compound of formulaIis prepared e.g. by reacting the compound of formula II with the reactive derivative of the carboxylic acid of formula III, and if necessary subjecting the resultant reaction product to the salt-forming reaction. The reaction is carried out in a solvent such as diethyl ether in the presence of an acid acceptor such as NaOH.
FIELD: biologically active substances. ^ SUBSTANCE: invention relates to improved method of obtaining total amount of phenol acid including following steps: (a) multi-rooted sage is extracted with water and filtered; (b) filtrate is placed in polyamide column and washed with water to neutral reaction, wash water is removed, and polyamide column is eluted with weak aqueous alkali solution, and obtained fractions are connected; (c) alkali fractions obtained in step (b) are acidified and placed in absorption column with macroporous resin, column is washed to neutral state, wash water is removed, column is eluted with aqueous or anhydrous lower alcohol, eluent is collected, evaporated at reduced pressure to remove alcohol, and dried. Yield of final product exceeds 4% based on amount of crude drug and content of total amount of phenol acid exceeds 80%. Thus obtained total amount of phenol acid can be used as drug for prevention and treatment of brain vessel diseases. ^ EFFECT: enlarged resource of vegetable material for preparation of vascular drugs. ^ 15 cl, 7 ex
Administered orally once daily for 24 weeks. After 24 weeks of treatment participants will be eligible to participate in an open-label extension period (Part C). Part C: 4 mg or 8 mg administered orally once daily for 52 additional weeks. After 76 weeks of treatment participants will be eligible to participate in an additional open-label extension period (Part D). Part D: 4 mg administered orally once daily for 52 additional weeks.
Spinal cord stimulation (SCS) involves an implantable pulse generator with the potential for enhanced therapeutic success through stimulation algorithms and parameters (28). Spinal cord stimulation (SCS) targeting distal areas, such as the dorsal root ganglion, may offer greater anatomical specificity in therapy. Subthreshold stimulation, utilizing high-frequency or burst energy delivery, has the potential to eliminate noxious and off-target paresthesiae. Recent studies have demonstrated that subthreshold stimulation at high frequencies and/or utilizing different stimulation paradigms can provide equal or even superior pain relief compared to standard SCS (29). The procedure entails the placement of two octapolar electrodes inserted through the epidural space, positioned beneath the dorsal area posterior to the spinal cord's posterior horn.
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that is associated with an increased risk of developing cutaneous malignancies. Clinical outcomes for these malignancies, including melanoma and keratinocyte cancers (KC), are worse for patients with CLL. Individuals with CLL develop an immunodeficiency of both the adaptive and innate immune system, which plays a role in the increased prevalence of skin cancers. This review focuses on the complex interplay between genetics, immunity, and pathogens that influence the cellular composition and biology of skin tumors and their microenvironment in CLL patients, and in comparison with other chronic hematological malignancies. It is paramount for dermatologists to be aware of the association between CLL (and chronic hematological malignancies more broadly) and cutaneous malignancies. This is a high-risk population who require regular and vigorous dermatologic follow-up.