anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Mindfulness-Based Stress Reduction (MBSR) as delivered in the parent study (Protocol ID #201410093) consisted of a brief introductory meeting, eight weekly 2.5-hour classes, and a retreat, followed by monthly booster sessions for approximately 15 months. Content included instruction in mindfulness meditation practices, gentle mindful movement, and exercises to enhance mindfulness in everyday life. For the current study, participants will continue monthly approximately 2.5 hour booster sessions covering similar content for the duration of the study. Participants will be encouraged to maintain daily formal meditative activities at home.
It refers to the standard treatment currently applied for foot ulcers at the Health Center where the study was conducted. The intervention was applied to the cohort, three times a week during 16 weeks or when the wound attained full epithelization. The wound bed was cleaned with physiological serum before application of Hydrogel.
FIELD: food industry, fish industry. SUBSTANCE: the present innovation deals with biologically active additives (BAA) obtained out of sea products that could be applied in dietary therapy for either prophylaxis or treating cardiovascular diseases. BAA contains food fish oil and biologically active substances (variants): concentrate of carotinoids, alcoholic extract of phospholipids' concentrate, alcoholic extract of phospholipids' concentrate with saponins obtained out of sea hydrobionts, such as sea cucumbers, sea hedgehogs and starfishes, herring, etc. The present innovation increases biological activity of fish oil, broadens assortment of curative-prophylactic products due to applying wide range of biologically active substances obtained out of hydrobionts. EFFECT: higher efficiency. 3 cl, 3 ex
A serine protease inhibitor and its application comprise Fc-serpin 3-404 and Fc-serpin 3-424, wherein the amino acid sequence of Fc-serpin 3-404 is shown as SEQ ID NO.1, and the amino acid sequence of Fc-serpin 3-424 is shown as SEQ ID NO. 2. The serine protease inhibitors Fc-serpin 3-404 and Fc-serpin 3-424 can be combined with TMPRSS11E, and effectively inhibit TMPRSS11E activity. Thus, the serine protease inhibitors of the present invention can effectively inhibit inflammatory response by inhibiting TMPRSS11E activity. The yeast strain for stably expressing the fusion protein is obtained, and has high expression quantity and low cost. In terms of purification, the affinity chromatography step in the purification process has high purification efficiency and is easy for large-scale production.
Carbidopa, levodopa and entacapone tablets are contraindicated in patients who have demonstrated hypersensitivity to any component (carbidopa, levodopa, or entacapone) of the drug or its excipients.

Monoamine oxidase (MAO) and COMT are the two major enzyme systems involved in the metabolism of catecholamines. It is theoretically possible, therefore, that the combination of entacapone and a non-selective MAO inhibitor (e.g., phenelzine and tranylcypromine) would result in inhibition of the majority of the pathways responsible for normal catecholamine metabolism. As with carbidopa-levodopa, nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with carbidopa, levodopa and entacapone tablets. These inhibitors must be discontinued at least two weeks prior to initiating therapy with carbidopa, levodopa and entacapone tablets. Carbidopa, levodopa and entacapone tablets may be administered concomitantly with the manufacturer’s recommended dose of MAO inhibitors with selectivity for MAO type B (e.g., selegiline HCl). (See PRECAUTIONS, Drug Interactions.)

Carbidopa, levodopa and entacapone tablets are contraindicated in patients with narrow-angle glaucoma.

Because levodopa may activate malignant melanoma, carbidopa, levodopa and entacapone tablets should not be used in patients with suspicious, undiagnosed skin lesions or a history of melanoma.
Abstract Described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a targeting agent. The composition can include a therapeutic agent. The therapeutic agent can be an antisense oligonucleotide (ASO). Exemplary ASOs are targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1; or targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Also described is a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer and a therapeutic agent that is an ASO such as an ASO targeted to a portion of a nucleic acid encoding Akt-1, and which modulates the expression of Akt-1 or an ASO targeted to a portion of a nucleic acid encoding HIF-1, and which modulates the expression of HIF-1. Pharmaceutical formulations, methods of making the lipid nanoparticles, and methods of using the lipid nanoparticles, for example for treating cancers, are also disclosed.
Nicotine replacement therapy (NRT), self-help materials, + brief in-person and telephone counseling, all conducted in Spanish. Computerized questionnaires at each of 5 visits and will take 1 1/2 hours to complete each time.
Due to their convenience, adhesive patch-type electrocardiographs are commonly used for arrhythmia screening. This study aimed to develop a reliable method that can improve the classification performance of atrial fibrillation (AF) using these devices based on the 2020 European Society of Cardiology (ESC) guidelines for AF diagnosis in clinical practice. We developed a deep learning model that utilizes RR interval frames for precise, beat-wise classification of electrocardiogram (ECG) signals. This model is specifically designed to sequentially classify each R peak on the ECG, considering the rhythms surrounding each beat. It features a two-stage bidirectional Recurrent Neural Network (RNN) with a many-to-many architecture, which is particularly optimized for processing sequential and time-series data. The structure aims to extract local features and capture long-term dependencies associated with AF. After inference, outputs which indicating either AF or non-AF, derived from various temporal sequences are combined through an ensembling technique to enhance prediction accuracy. We collected AF data from a clinical trial that utilized the MEMO Patch, an adhesive patch-type electrocardiograph. When trained on public databases, the model demonstrated high accuracy on the patch dataset (accuracy: 0.986, precision: 0.981, sensitivity: 0.979, specificity: 0.992, and F1 score: 0.98), maintaining consistent performance across public datasets. SeqAFNet was robust for AF classification, making it a potential tool in real-world applications.
The invention discloses healthcare sand for a local chicken playground. The healthcare sand for the local chicken playground is characterized by being prepared from river sand, shell powder, rock powder, bone meal, charcoal powder, salt powder and a medicinal herb preparation. The healthcare sand is used so that feathers on the body surface of a local chicken are in fully contact with the healthcare sand, the robust constitution of the local chicken can be kept, and growth is exuberant. The healthcare sand can also be eaten by the local chicken to promote assimilation of the local chicken on food. The medicinal herb preparation contained in the healthcare sand can kill pathogens such as germs and parasites on the body surface, the immunity of the organism of the local chicken is improved, the disease resistance of the local chicken is improved, the meat quality and flavor of the local chicken can be easily improved, and the function of improving the deliciousness of the meat quality of the local chickens is achieved. The local chicken bred on the playground with the healthcare sand is fresh, sweet and delicious in meat quality, fine, smooth and tough in taste, pure in quality, quite bright in feather color, especially beautiful in appearance, bright, red and large in cockscomb, high in nutritive value and small in fat content and is truly green, delicious and nutritious food.
PROBLEM TO BE SOLVED: To obtain a dopamine derivative-containing suppository, good in elution property and absorption in the body and having excellent bioavailability. SOLUTION: This suppository contains a dopamine derivative of the formula (R is methyl or 2-methylthioethyl) and a water-swelling polymeric substance in a water-soluble base material (e.g. polyethylene glycol). The content of the dopamine derivative is 1-60wt.%, the content of the water-soluble base material is 35-90wt.% and the content of the water-swelling polymeric substance is 1-30wt.%, each based on the total of the preparation. As an example of the dopamine derivative, (-)-(S)-2-acetamido-N-[3,4-bis(ethoxycarbonyloxy) phenethyl]-4-(methylthio)butylamide is cited, and as an example of the water- swelling polymeric substance, an internally crosslinked polyvinylpyrrolidone, chitosan, etc., is cited. Preferably, other various additives are adequately compounded and the mixture is formulated by a heat fusing method, and the weight of each preparation is 1-2g.
Chronic disease risk, including breast cancer risk, is not uniform across race and ethnic groups in the United States. This variation in disease risk may be due to environmental exposures (including diet), genetic susceptibility, disparities in access to health screening, diagnosis and medical care, or combination of these factors. Here we have shown that Hispanic women in the U.S. are more likely to be overweight or obese compared to non-Hispanic whites. Some of the excess obesity risk is likely due to the lack of neighborhood availability and affordability of fruit, vegetables, lean protein and whole grains. Whether an inexpensive and widely available highly processed/refined, nutrient poor diet superimposed on a genetic background favoring adipose deposition (i.e., the "thrifty genotype") is metabolically detrimental has not been investigated. Research to test the metabolic response to Indigenous and Western diets in Hispanic women may provide important information about the etiology of obesity and obesity-related diseases in Hispanic women, including risk of breast cancer. Since reducing disparities in obesity-related diseases, including breast cancer, is an important public health goal, identifying potential programs for prevention should receive high priority.

Mexicans are the largest immigrant group in the United States with an estimated 10 million Mexican-American women currently in the U.S. As they acculturate to this country, Mexican immigrants change their dietary habits from traditional (indigenous) foods with plentiful fruit, vegetables and complex carbohydrates rich in fiber and other compounds to a Western-style diet high in fat and refined carbohydrate, but low in plant foods. Particularly concerning is that the food choices made by Mexican immigrants, many of whom are of lower socio-economic status, are driven partly by their inability to procure and purchase healthy foods. The disparity in both food availability and purchasing power fuels a tendency to obtain and consume a low-cost, Western style diet. When this diet is superimposed on persons with a "thrifty genotype" who are evolutionarily adapted to diets high in legumes and complex carbohydrates, it may lead to an abnormal metabolic response that favors adipose deposition and numerous health risks. Thus, ancestral genetic characteristics likely have an important role in metabolic response to specific dietary patterns and subsequent health risks. This phenomenon may partly explain the tendency for Mexicans and other immigrants from the Americas to become obese after just one generation in the United States.
The invention relates to gentle face wash capable of naturally removing acne marks and blackheads and whitening and rejuvenating skins and a preparation method thereof. The face wash provided by the invention has better functions of whitening and rejuvenating skins and effectively removing acne marks and blackheads. The method provided by the invention has the characteristics of simplicity and convenience in preparation and relatively low cost. The gentle face wash comprises the following components by weight percent: 30-50% of white sugar, 5-10% of glycerol monolaurate, 16-35% of surfactant composition and the balance of water. The preparation method of the face wash comprises the following steps: I. weighing the raw materials including the white sugar, glycerol monolaurate, surfactant composition and water; II. grinding the white sugar into powder, and then sieving the powder with a 200-500-mesh sieve; III. carrying out microwave sterilization on the sieved white sugar; IV. putting all the raw materials into a reactor to be stirred uniformly, thus obtaining the face wash.
The ETV6::ABL1 fusion defines a subgroup of myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions. We report a case of extramedullary involvement and leukemic transformation in myeloproliferative neoplasm (MPN), where ETV6::ABL1 was initially overlooked but later detected in the blast phase. ETV6::ABL1 burden was very low during the MPN phase but increased substantially during the blast phase. This correlation between ETV6::ABL1 burden and disease phenotype indicated that an immature leukemic clone is the sole carrier of ETV6::ABL1, suggesting that ETV6::ABL1 is not the primary driver of the MPN phase. Moreover, only the blast phase revealed somatic mutations in RUNX1 and STAG2, or complex karyotype, while the MPN phase revealed no molecular and cytogenetic abnormalities. Therefore, it remains uncertain whether the small clone of ETV6::ABL1 influenced the manifestation of MPN or if another underlying driver was responsible for the MPN phase, necessitating further research.
Three dried ferrous sulphate and folic acid tablets every morning 30 mins before the meal. If side effects occur the drug may be taken with the meal or in 2 separate doses per day. The treatment will be pursued for 3 months after correction of anemia.
A food-grade tableware cleaning agent belongs to the category of surfactants, all components of the food-grade tableware cleaning agent are food materials specified by related national food safety standards, and the food-grade tableware cleaning agent is a genuine edible 'detergent'. The cleaning agent is particularly used for cleaning household tableware, washing hands of infants and food operators, cleaning meat surfaces, and cleaning chopping boards and cutting tools for processing food. The product not only achieves the basic aims of removing oil stains, sterilizing and inhibiting bacteria, having no residual hazard, natural degradation and the like, but also has the advantages of mild cleaning and skin protection, little foam, easy cleaning, water saving and environment protection and the like. The cleaning time is prolonged to make up for the deficiency that the decontamination capability of the product is weaker than that of the daily chemical products, and the washing time can be saved due to the advantages of less foam, easy washing, no residue and harm and the like. The cost of water saved by flushing is reduced, the cost increased by most raw materials can be reduced, and water resources can be saved. All the components are products of industrial production, and the method is suitable for large-scale batch production and convenient to use.
INTRODUCTION: Male breast cancer accounts for 1% of all breast cancers. Its low frequency leads to a lack of awareness, resulting in significant diagnostic delays. Additionally, this limits the available evidence, which primarily uses diagnostic-therapeutic algorithms based on women.
OBJECTIVES: To analyze the prevalence, clinical presentation, anatomical and pathological characteristics, and prognosis of male breast cancer using one of the largest series available. Secondarily, to compare our data with studies conducted in women.
MATERIALS AND METHODS: A multicenter, observational, descriptive, retrospective study was conducted in the autonomous community of Aragon, Spain, from 1995 to 2022 including men with a pathological diagnosis of breast cancer.
RESULTS: A total of 148 patients were included, with a prevalence of 1%. The most common clinical presentation was a palpable retroareolar mass. Invasive ductal carcinoma was the most frequent type (88.89%), and luminal B was the predominant subtype (47.76%). Surgery was the most utilized treatment; mastectomy was performed in 90.34% and AL in 46.89%. At diagnosis, 52.46% had extramammary involvement. The recurrence rate was 24.1%, and the mortality attributed to the disease was 14.6%.
CONCLUSIONS: There is a high rate of metastatic involvement at diagnosis, a high percentage of mutilating surgeries, and a high number of recurrences compared to available studies on males. Additionally, a worse prognosis is observed compared to breast cancer in women, despite these tumors having a less aggressive molecular subtype. These findings highlight the importance of conducting studies focused on men to develop specific protocols.
In the previous pilot study, reactivation of VZV was confirmed in 63.6% of the patients as having RCVS by cell mediated immune response (CMI) test and 18.2% by Saliva PCR. None of patients who were simply stressed showed reactivation of VZV. Considering about 20% had false negative results in angiographic findings of RCVS, we set the effect size as 0.63 in group of subjects and 0.12 in group of controls. Using alpha values of 0.05 and beta values of 0.2, we calculated the target number of the study. If the ratio of cases to controls is 1:2, 9 case-patients and 18 control-patients were needed and if the ratio is 1:3, 8 case-patients and 24 control-patients were needed. We expect to enroll 10 case-patients and 20 to 30 control-patients within two years, considering the drop rate of 10\~20%.

Baseline clinical information regarding age, sex, smoking history and medical comorbidities including hypertension (treated, systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg at discharge), diabetes (treated, fasting blood glucose ≥126 mg/d), hyperlipidemia (treated, total cholesterol level ≥200 mg/dl or low-density lipoprotein level ≥140 mg/dl) and coronary artery disease will be collected on admission. Laboratory tests, including complete blood count, blood chemistry, c-reactive protein and erythrocyte sediment rate wil be performed. Images of brain MRI, MR angiography, CT angiography or digital substraction angiography will be gathered if present.

Tests for VZV specific antibody responses and T-cell mediated immune response will be performed by VZV specific ELISA and IFN-γ ELISPOT, respectively. Result for T cell responses will be shown as spot number per 10\^6 PBMCs. On the day of blood sample collection, plasma will be isolated and freezed (-80℃). Peripheral mononuclear cells will be separated from the remaining blood samples and keep freezed (-190℃). Melt the frozen peripheral mononuclear cells and inoculate them on a plate (T-Track human IFN-γ, Lophius) with anti-human IFN-γ antibody and inoculate VZV lysate (Microbix) 50 ug/mL on them. After incubating 24 hours, the staining will be performed and the spot will be read in a automated ELISPOT reader (ELR07 reader system, Autoimmune Diagnostika GmbH).

For statistical analysis, patients with thunderclap headache will divided into two groups according to the presence of RCVS. Among them, the rate of infection with varicella zoster virus will be compared and analyzed. Fisher's exact test, Mann-Whitney test, Pearson correlation will be performed. Also, logistic regression analysis will be used, and covariates will be adjusted if needed. Sensitivity and specificity of tests for reactivation of VZV and RCVS will be analyzed too.
Objective: The purpose of this study is to evaluate the safety and feasibility of intra-arterial and intravenous injection of autologous bone marrow mononuclear cells in patients in the acute and sub-acute phase (\> 3 and \< 90 days after symptoms onset) of ischemic cerebral infarct in the middle cerebral artery territory.

Methods: 15 patients with cerebral infarct within the middle cerebral artery territory will be enrolled in this prospective, nonrandomized, open-labeled study. Up to 10 patients will receive up to 500x 10 6 autologous bone marrow cells injected intra-arterially into the middle cerebral artery through percutaneous approach. The procedure is monitored by Transcranial Doppler (TCD) and electroencephalogram (EEG). Other 5 patients will receive up to 500x 10 6 autologous bone marrow cells injected intravenously. Changes in neurological deficits and improvements in functions will be evaluated at baseline and at regular intervals during follow-up ( 4 months). EEG and neuroimaging exams will be performed at baseline and at regular intervals during the follow-up period.
Patients receive peposertib PO BID on days 1-21, days 1-28, or days 1-7 (depending on dose level) and pegylated liposomal doxorubicin hydrochloride IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scan or MRI during screening and every 8 weeks and after 6 months of study treatment, every 12 weeks. Patients undergo ECHO during screening and every 6 months. Starting in cycle 13, patients undergo ECHO or MUGA scan every 2 cycles. Additionally, patients undergo blood sample collection throughout the study.
INTRODUCTION: The breathing and suspended inspiration techniques are often used interchangeably for spine X-ray examinations. However, these techniques are not always adequately supported by clinical evidence. This study aimed to determine the two techniques' diagnostic value and adverse image outcomes.
METHODS: A total of 400 participants were examined on a Siemens Ysio Max system and randomized into four examination groups: suspended inspiration or breathing techniques with exposure times of 1, 2, and 3.2 s, respectively. Two consultant radiologists conducted the evaluation of the X-ray images. If disagreement was present, the radiologists collaboratively reviewed the X-ray images until a consensus was reached.
RESULTS: The final 394 study population comprised 275 women and 119 men with a mean age of 64 years (range:18-96 years). The proportions of visually sharp reproduction of the endplates and trabecular structures did not differ significantly with regards to differences in exposure times between groups. The breathing technique groups had significantly higher proportions of blurring and motion artifacts (p < 0.001). However, adverse image outcomes (motions artifacts) were significantly lower in the 1-s exposure group.
CONCLUSIONS: The suspended inspiration and breathing techniques performed equally well regarding visually sharp reproduction. However, the suspended inspiration technique was superior to the breathing technique. regarding adverse image outcomes, although the latter could be improved by using a shorter exposure time.
IMPLICATIONS FOR PRACTICE: The suspended inspiration and breathing technique appeared to perform at equal diagnostic levels. The suspended inspiration technique should be preferred due to its reduced risk of adverse image outcomes. However, the risk could also be reduced using a short exposure time with the breathing technique.