anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Comorbid conditions represent a major risk for severe illness among persons with COVID-19. Previously healthy people with COVID-19 can also develop severe illness, but are expected to have better outcomes than those with comorbid conditions. Nevertheless, recent data suggest that the former may have, counterintuitively, higher risk of death among those with non-COVID sepsis. However, the epidemiology and outcomes of previously healthy people among critically ill patients with COVID-19 are unknown. We used statewide data to identify intensive care unit (ICU) admissions aged ≥18 years in Texas with COVID-19 in 2020. Multilevel logistic regression was used to estimate the association of comorbid state with short-term mortality (defined as in-hospital mortality or discharge to hospice) overall and with higher illness severity among ICU admissions. Among 52,776 ICU admissions with COVID-19, 6373 (12.1%) were previously healthy. Short-term mortality among previously healthy ICU admissions and those with comorbidities was 16.9% versus 34.6%. On adjusted analyses, the odds of short-term mortality were lower among the previously healthy compared to those with comorbidities overall (adjusted odds ratio (aOR) 0.84 (95% CI: 0.73-0.98)), but did not differ among those with ≥3 organ dysfunctions (aOR 1.11 (95% CI: 0.84-1.46)) and the mechanically ventilated (aOR 0.87 (95% CI: 0.68-1.12)), while being higher among those with do-not-resuscitate status (aOR 1.40 (95% CI: 1.04-1.89)). Over one in eight ICU admissions with COVID-19 were previously healthy. Although being previously healthy was associated with lower risk of death compared to those with comorbidities overall, it had no prognostic advantage among the more severely ill.
To investigate the effects of the addition of motorized movement therapy versus conventional chest physiotherapy alone on pulmonary functions, exercise capacity, and endurance in children with Down Syndrome (DS). Methods: This randomized controlled study included 40 children (24 boys \& 16 girls) with DS. Their ages ranged from 9 to 13 years. The control group received conventional chest physical therapy program, three sessions per week for 12 weeks. The study group received an aerobic exercise regimen using a motorized movement therapy device 3 times /week in addition to the same traditional program used with the control group. Pulmonary function tests, and six-minutes walking test were measured at baseline, after 18 sessions and after 36 sessions of treatment.
OBJECTIVES: The prognostic factors in patients with malignancy-related ascites (MA) have been poorly investigated. This study aimed to evaluate both the prognostic impact of MA on terminally ill patients with cancer and the prognostic factors in those with MA.
METHODS: This was a post hoc analysis of a multicentre, prospective cohort study. Patients with advanced cancer admitted to palliative care units at 23 institutions and aged≥18 years were enrolled between January and December 2017. Overall survival (OS) was compared according to MA. A multivariate analysis was conducted to explore prognostic factors in patients with MA.
RESULTS: Of 1896 eligible patients, gastrointestinal and hepatobiliary pancreatic cancers accounted for 42.5%. 568 (30.0%) of the total had MA. Patients with MA had significantly shorter OS than those without MA (median, 14 vs 22 days, respectively; HR, 1.55; 95% CI, 1.39 to 1.72; p<0.01). A multivariate analysis showed that MA was a poor prognostic factor (HR, 1.30; 95% CI, 1.13 to 1.50; p<0.01) and that among patients with MA, significant poor prognostic factors were liver metastasis, moderately to severely reduced oral intake, delirium, oedema, gastric cancer, high serum creatinine, high serum C reactive protein, high serum total bilirubin, dyspnoea and fatigue, while significant good prognostic factors were female sex, good performance status, high serum albumin and colorectal cancer.
CONCLUSIONS: MA had a negative impact on survival in terminally ill patients with cancer. A multivariate analysis revealed several prognostic factors in patients with terminal cancer and MA.
<P>PROBLEM TO BE SOLVED: To provide a collagen cosmetic surely usable in a state without quality deterioration by denaturation or putrefaction of collagen.  <P>SOLUTION: The collagen cosmetic comprises an aqueous solvent and a dried substance of solubilized collagen separate from the aqueous solvent for dissolving in use. The dried substance of the solubilized collagen is a solubilized collagen fiber having pH≤5.0 isoelectric point and ≤40 dtex average fineness. The cosmetic is composed by preparing the solubilized collagen having pH≤5.0 isoelectric point, preparing an aqueous solution of the solubilized collagen having a higher pH than the isoelectric point of the solubilized collagen, removing water therefrom and preparing the solubilized collagen fiber. Furthermore, the collagen fiber can be produced by an apparatus having a solvent tank housing the organic solvent, a means for discharging the aqueous solution of the solubilized collagen into a filamentary form in the solvent and a means for making the solvent flow in the direction crossing the discharge direction and cutting the collagen coagulated into the filamentary form.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
A carbomer cervical gel is mainly composed of carbomer, glycerin, triethanolamine, benzyl alcohol, disodium ethylene diamine tetraacetate (EDTA-2Na) and water. In 100 g of the gel, various components comprise: 0.1-10 g of carbomer, 2-10 g of glycerin, 0.1-1.0 g of triethanolamine, 0.01-1.0 g of disodium ethylene diamine tetraacetate, 0.03-5.0 g of benzyl alcohol, and the balance water, wherein the content of -COOH is 0.1-0.3 g. Carbomer is the main component of the gel and is used for the formation of the gel. Glycerin is a humectant and has a lubrication effect. triethanolamine is an antalkali. Benzyl alcohol is an antiseptic and has disinfection and anticorrosion functions. Disodium ethylene diamine tetraacetate (EDTA-2Na) is an anti-oxidant and is used for preventing products from oxidizing and denaturizing. The gel product provided by the invention is used to reduce erosion area, promote healing of cervical erosion area, mitigate degree of local inflammation, minimize leukorrhagia and improve symptoms such as postcoital bleeding, lumbosacral pain, blood and puriform leucorrhea and the like.
PROBLEM TO BE SOLVED: To obtain a shaving aid, capable of preventing an active ingredient from tightly binding to shaving system and protecting the active ingredient during process, by making the shaving aid contain at least one kind of water- sensitive complex-forming agent. SOLUTION: This shaving aid contains (A) an active ingredient (preferably a lubricant, vitamin E, menthol, a mineral oil, a medicine, a cosmetic, etc.) and (B) molecule of at least one kind of a water-sensitive complex-forming agent [preferably a cyclic polysaccharide or a cyclodextrin, etc.] individually forming a complex in at least part of each molecule of the component A. This shaving aid is prepared by forming an inclusion complex by bringing the component A into contact with the component B and incorporating the inclusion complex into a shaving system. Thereby, deterioration of the active ingredient due to processing and lowering of effect can be minimized.
Warfarin monotherapy 10 mg/day for \>=2 to \<=4 days, then Warfarin 0-15 mg/day for 4 days (Treatment Period 2). A 14-day washout period will separate Treatment Periods 1 and 2.
OBJECTIVES: The trough concentration of vancomycin and the area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ratio are crucial in determining vancomycin efficacy against methicillin-resistant Staphylococcus aureus. However, the use of similar pharmacokinetic principles in determining antibiotic efficacy against other gram-positive cocci is lacking. We performed a pharmacokinetic/pharmacodynamic analysis (association of target trough concentration values and AUC/MIC with therapeutic outcome) of vancomycin in patients with Enterococcus faecium bacteraemia.
METHODS: Between January 2014 and December 2021 we performed a retrospective cohort study of patients with E. faecium bacteraemia treated with vancomycin. Patients who received renal replacement therapy or had chronic kidney disease were excluded. Clinical failure, the primary outcome, was defined as a composite of 30-day all-cause mortality, vancomycin-susceptible infection requiring change of treatment, and/or recurrence. AUC24 was estimated using a Bayesian estimation approach based on an individual vancomycin trough concentration. The MIC for vancomycin was determined using a standardised agar dilution method. Additionally, classification was used to identify the vancomycin AUC24/MIC ratio associated with clinical failure.
RESULTS: Of the 151 patients identified, 69 were enrolled. All MICs of vancomycin for E. faecium were ≤1.0 µg/mL. The AUC24 and AUC24/MIC ratio were not significantly different between the clinical failure group and the clinical success group (432±123 µg/mL/hour vs 488±92 µg/mL/hour; p=0.075). However, 7 of 12 patients (58.3%) in the clinical failure group and 49 of 57 patients (86.0%) in the clinical success group had a vancomycin AUC24/MIC ratio ≥389 (p=0.041). No significant association between trough concentration or AUC24 ≥600 µg/mL×hour and acute kidney injury was observed (p=0.365 and p=0.487, respectively).
CONCLUSION: The AUC24/MIC ratio is associated with the clinical outcome of vancomycin administration in E. faecium bacteraemia. In Japan, where vancomycin-resistant enterococcal infection is rare, empirical therapy with a target AUC24 ≥389 should be recommended.
<P>PROBLEM TO BE SOLVED: To improve convenience of diagnosing by controlling the propriety of referring to a medical image inconsistent with imaging order information corresponding to a diagnostic environment of referring to the medical image.  <P>SOLUTION: An image server 30 registers consistent DICOM image data to be released and registers inconsistent DICOM image data to be put on hold. An ER-WS terminal 50 receives the DICOM image data registered to be released/put on hold from the image server 30. Then, when the DICOM image data registered to be put on hold are referred to and displayed, ED document data are generated and transmitted to the image server 30. A WS terminal 40 receives the DICOM image data registered to be released from the image server 30. Further, when the ED document data corresponding to the DICOM image data are present in the image server 30, the ED document data are received as well.  <P>COPYRIGHT: (C)2009,JPO&INPIT
The glomus tumor is a rare neoplasm that is typically found subungually in the extremities and functions as a specialized neurovascular organ. An extremely rare site for glomus tumors is the breast, with only a few reported cases. Breast glomus tumors present with three typical clinical signs: dull pain, focal tenderness, and cold sensitivity. Less than 10% of all glomus tumors are malignant. We herein present a case of a malignant glomus tumor originating in the breast. Distant metastasis was ruled out, and the tumor was completely resected. However, the patient unexpectedly developed rapid systemic metastasis, detected 5 weeks after tumor removal. Despite the administration of analgesics and targeted therapy, the patient died 1 month later. When treating patients with undiagnosed breast tumors, clinicians should pay attention to unexplained and repeatedly reported symptoms and consider the possibility of a rare disease. Our literature search revealed no cases of malignant glomus tumors originating in the breast, making this case the first of its kind.
An exemplary system for coupling acoustic energy using an encapsulated coupler member comprises a display or indicator, a control system, a probe, and a coupler member. This invention provides a coupler member adjustably configured to perform at least one of (i) providing a standoff, (ii) focusing or defocusing energy, and (iii) coupling energy. An exemplary gel coupler member is configured to hold the shape of a lens geometry. In one aspect of the present invention, gel coupler member comprises water, glycerol, and polyvinyl alcohol, and exhibits an increased desiccation time and shelf life when compared to the prior art. The probe can comprise various probe and/or transducer configurations. In an exemplary embodiment, the probe delivers focused, unfocused, and/or defocused ultrasound energy to the region of interest. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
In group 2 the same procedure will be performed, but the injectate will consist of 5 mL of a balanced crystalloid intravenous solution (4 ml of normal saline) plus 4 mg dexamethasone (each side). This procedure will be performed bilaterally.
Patients receive BKM120 PO daily and rituximab IV. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients with asymptomatic progression may continue treatment for up to 12 months. Pharmacodynamic samples from peripheral blood (for those with peripheral blood involvement) and bone marrow aspirate (for all patients) are drawn at baseline. Patients will undergo correlative studies to include bone marrow biopsy at study enrollment, and at the time of complete remission.
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's anti-nociceptive and antiseizure effects in animals. In animal models of nerve damage, pregabalin has been shown to reduce calcium-dependent release of pro-nociceptive neurotransmitters in the spinal cord, possibly by disrupting alpha2-delta containing-calcium channel trafficking and/or reducing calcium currents. Evidence from other animal models of nerve damage and persistent pain suggest the anti-nociceptive activities of pregabalin may also be mediated through interactions with descending noradrenergic and serotonergic pathways originating from the brainstem that modulate pain transmission in the spinal cord.
    While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Aging is a constant, natural and inevitable process in living creatures' lives, characterized by bio psychosocial and cultural changes that are affected by intrinsic factors such as genetics and by extrinsic factors such as acquired experiences and the environment (World Health Organization \[WHO\], 2010).

Geriatrics refers to medical care for older adults, there is no set age to define older age, but age greater than 65 is mostly used. The elderly, or those older than 65 years, currently represent 12.5 percent of the U.S. population.With increasing life spans across the world, Pakistan is also experiencing a rise in its elderly population.According to 1998 Census report, in Pakistan the population of over-60 years increased to 7.34 million .Functional capacity is a complex concept that includes basic activities of daily living (BADL), instrumental activities of daily living (IADL),and advanced activities.BADL demonstrate the effectiveness of rehabilitation, and determine a person's ability to perform activities of daily living.The BADL may decline due to age, a specific disease, or a variety of factors such as decreased muscle strength, loss of vision, and postural changes Functional decline in older people is nearly 12% in those more than 75 years of age. According to (ECHP) people over 65 in the European Community, it is observed that 21% of the population is severely deteriorated to carry out activities of daily living, and this figure rises up to 29% for people over 75 years old. France would be the European country with most dependence in the ADL (28% of people over 65). The estimate of prevalence of physical disability in older adults of Punjab Pakistan varied from 13.9% to 36.6%.The assessment of functional status is critical when caring for older adults. A functional assessment can also guide the clinician to focus on the person's baseline capabilities, facilitating early recognition of changes that may signify a need either for additional resources or for a medical work-up. number of questionnaires are available to assess IADL, however, no gold standard exists . One of the most widely used is the Lawton Instrumental Activities of Daily Living Scale developed in 1969 by Lawton and Broady. Lawton IADL is an 8-item scale used to assess independent living skills. It is most useful for identifying how a person is functioning at a present time and to identify improvement or deterioration over time.
The intervention group will complete a short survey called the WE CARE HOUSTON survey. The WE CARE HOUSTON survey has been designed to quickly assess patient need for local services that address the social determinants of health. The WE CARE HOUSTON survey will be administered on paper or verbally if family is not able to read. Based on the parent's responses to the screening survey, the study investigators will use an algorithm to direct families to appropriate services and community resources. Families who screen positive for social needs will receive a handout on resources. For the families that screen positive for depression/ mental health needs, domestic violence, or alcohol and drug abuse, the study investigators will notify the medical/clinical team and recommend an inpatient social work prior to discharge. Intervention participants will be called 1 week-2 months after enrollment to follow up on resources and will be called for a 6 month follow up structured telephone survey.
Patients will receive 1g tranexamic acid in 100mL solution intravenously in the operating room before inflation of the tourniquet. They will again receive the same IV solution in the post-anesthesia care unit, approximately 3 hours after the first solution was given. They will also receive a 75cc topical saline solution approximately 5 minutes before the tourniquet is released.
The specific contribution of focal damage of the prefrontal cortex and the cognitive mechanisms accounting for communicative-pragmatic disorders remains unclear. The objective of the current study was to investigate the impact of focal prefrontal cortex damage on the ability to understand indirect speech or hints and to identify the prefrontal neural mechanisms involved. We also examined the underlying cognitive mechanisms of disorders of indirect speech understanding particularly theory of mind and executive functions. Thirty patients with focal prefrontal cortex damage and 30 control subjects were compared on their performances on the Hinting task assessing pragmatic language skills, the "Faux-Pas" task and the Reading the Mind in the Eyes task assessing Theory of Mind and a battery of executive tasks. Patients were significantly impaired compared with control subjects on all these abilities. Both deficits of executive functions and theory of mind were able to predict impaired ability of patients in understanding non-literal meanings on the Hinting task. Finally, using voxel-based lesion analysis we identified a partially shared neural prefrontal network involved in all these abilities centered on the dorsomedial and ventral regions of the prefrontal cortex.
A manufacturing method of a cactus instant powder belongs to food processing technology. The present invention takes the fresh cactus as raw material. Firstly, the cactus is processed dehydration, drying and enzyme treatment. Secondly, the cactus is processed preparing and grinding treatment. Thirdly, the cactus is processed homogenization and spray granulation. And lastly, the finished production is made. The present invention is characterized in that the cactus is not processed juice extraction procedure, which makes the bioactive components have high preservation rate and rich nutrition, uses agglomeration regenerated granules and spraying lecithin technology to make the product have good instant solubility, and adopts enzymolysis treatment to make the soluble components completely release and dissolve, which makes the product reserve the light green color of the raw material.
The invention relates to a livestock traditional Chinese medicine composition having functions of tonifying qi, nourishing blood, stimulating the menstrual flow and stimulating milk secretion. The composition comprises following components by weight: 10-30 parts of astragalus root, 10-40 parts of Chinese honeylocust spine, 10-20 parts of Chinese angelica root, 10-20 parts of radix codonopsitis, 10-30 parts of globethistle root, 10-30 parts of rhizome of Sichuan lovage, 10-20 parts of seed of cowherb, 10-20 parts of fruit of beautiful sweetgum and 1-10 parts of iron-dextrin. The formulation of the composition is scientific and reasonable. The composition has the functions of tonifying qi, nourishing blood, stimulating the menstrual flow and stimulating milk secretion. The composition is free of toxic and side effects and medicine residues, and is convenient to use and low in cost. The composition can be used for treating common postpartum hypogalactia, breast milk stoppage, and the like for livestock.
Embodiments are generally directed to systems and apparatuses for tracking usage of an item. For example, an apparatus may be provided for tracking use of a packetized item. The apparatus may include a microprocessor, a power source, and a structural layer to which the microprocessor and power source are coupled. The structural layer may include a container that is configured to hold various items. The container may also include an opening that allows access to the items. The apparatus may further include a cover layer that is configured to cover the opening of the container. The cover layer may include at least one bendable sensor placed over the opening of the container. The microprocessor may be configured to determine, using detected movements in the bendable sensor, whether the container has been opened.