anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Atopic dermatitis (AD)is an inflammatory skin disease characterized by itching, dry skin and recurrent inflammatory eczema. It is one of the most common skin diseases and is associated with reduced quality of life, functional impairment and sleep difficulties. There are currently no pharmacological treatments that are effective in curing the disorder in the longer-term. Itching is one of the core symptoms in AD and it has been shown that the behavioral response to itching, scratching, has a maintaining function in AD. Reducing scratching may therefore play an important role in alleviating AD. Although behavioral aspects play a significant role in AD only a few studies have investigated the effect of psychological treatment for AD. These studies have shown promising results and the present study aim to add to the body of knowledge by testing a new form of cognitive behavioral treatment for AD. This new treatment is based on the idea that patients could benefit from training in exposure to events that could lead to increase in itching while refraining from scratching. To enable this the treatment incorporates more recently developed cognitive behavioral components such as mindfulness training.

The present study aims to investigate a new exposure-based cognitive behavioral psychological treatment for the disorder. The trial is a small scale open trial (n=25) with assessments at baseline, post-treatment and 6-month follow-up. The primary outcome is the SCORAD.
Neutrophils rapidly respond to inflammation and infection, but to which degree their functional trajectories after mobilization from the bone marrow are shaped within the circulation remains vague. Experimental limitations have so far hampered neutrophil research in human disease. Here, using innovative fixation and single-cell-based toolsets, we profile human and murine neutrophil transcriptomes and proteomes during steady state and bacterial infection. We find that peripheral priming of circulating neutrophils leads to dynamic shifts dominated by conserved up-regulation of antimicrobial genes across neutrophil substates, facilitating pathogen containment. We show the TLR4/NF-κB signaling-dependent up-regulation of canonical neutrophil activation markers like CD177/NB-1 during acute inflammation, resulting in functional shifts in vivo. Blocking de novo RNA synthesis in circulating neutrophils abrogates these plastic shifts and prevents the adaptation of antibacterial neutrophil programs by up-regulation of distinct effector molecules upon infection. These data underline transcriptional plasticity as a relevant mechanism of functional neutrophil reprogramming during acute infection to foster bacterial containment within the circulation.
'Enjoy Your Bump (EYB)' is an online life skills course based on Cognitive Behavioural Therapy (CBT) principles which has been designed to specifically support women in the antenatal period. A survey of women and health professionals has demonstrated that this is a resource that both groups find acceptable. The aim of this quasi-experimental feasibility study is to evaluate the user experience and efficacy of this online programme as a non-pharmacological, low intensity intervention for women experiencing mild-moderate depressive symptoms in pregnancy. This will be achieved by measuring depression and anxiety as well as measures of attachment to the developing baby, pre and post intervention. It is hoped the results from this study will help inform whether this is a resource that should be made more widely available to women in the National Health Service (NHS). It is hypothesised that the 'Enjoy Your Bump' will be an acceptable and effective intervention for women experiencing mild to moderate depressive symptoms in the antenatal period.
The invention discloses a traditional Chinese medicine composition for treating diarrhea. The traditional Chinese medicine composition is composed of the following traditional Chinese medicine raw materials, by weight, 10-30 parts of gen-seng, 5-25 parts of poria cocos, 10-30 parts of Chinese yam, 5-25 parts of bighead atractylodes rhizome, 5-15 parts of hyacinth beans, 3-10 parts of licorice, 2-8 parts of dendrobium, 2-8 parts of polyghace seche, 3-10 parts of polygonatum rhizome, 2-7 parts of Gorgon fruit and 1-10 parts of lotus seeds. Under the traditional traditional Chinese medicine theory and clinic experience guidance, medicament ingredients are selected carefully, the ingredients of the composition employ natural traditional Chinese medicine raw materials, and most of the traditional Chinese medicine raw materials have functions of tonifying spleen and benefiting qi. Preparation is simple, medicine sources are wide, and the cost is low. The prescription medication principle of traditional Chinese medical science is followed, and all the ingredient medicaments are subjected to water decoction and then are taken. The traditional Chinese medicine composition is verified by clinic application, the curative effects are substantial, the functions are reliable, medical properties are mild, the composition has no toxic or side effects, the clinic cure rate is 78.95%, and the total effective rate is 97.38%.
<P>PROBLEM TO BE SOLVED: To provide a granulated substance as an oral solid preparation that has excellent temporal stability and contains an HMG-CoA reductase inhibitor.  <P>SOLUTION: The granulated substance is obtained by granulating an HMG-CoA reductase inhibitor or a mixture of the inhibitor and a basic amino acid with a gastrosoluble polymer. Preferably the HMG-CoA reductase inhibitor is selected from the group consisting of fluvastatin, atorvastatin, pitavastatin, rosuvastatin and their salts. Preferably the basic amino acid is arginine, lysine or histidine. Preferably the gastrosoluble polymer is a polyvinyl acetal diethyl aminoacetate or an aminoalkyl methacrylate copolymer.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Patients in the MICU after lung transplantation were enrolled, and alveolar lavage fluid was obtained within 48 hours of the patient's surgery, divided into aliquots, and subjected to macrogenomic sequencing, routine microbiological testing and cytokine testing. Patients will be divided into pneumonia group if they had a co-infection at the time of sampling.
Glaucoma is the second cause of blindness worldwide. Laser peripheral iridoplasty (LPI) is a simple and effective treatment for angle closure glaucoma. LPI can widen or reopen an existing angle close or angle adhesion in order to reduce the risk of attack of the angle closure glaucoma. However, there are very little research on the laser site, laser wavelengths, laser energy and laser spot intervals.

The purpose of this study is to determine the optimum laser site of LPI. Before and 7days, 1 month, 3 months after LPI, the structure of anterior chamber, including angle anterior chamber depth(ACD), angle of anterior chamber (AA), anterior chamber angle opening distance 750(AOD750) are measured with ultrasound biomicroscopy. Before and 7days, 1 month, 3 months after LPI, the outflow resistance of aqueous humor are evaluated with C value. Before and 1hour, 1days, 3day, 7days, 1 month, 3 months after LPI, intraocular pressure are measured with Goldmann tonometry. Before and 3 months after LPI, retinal nerve layer thickness and the optic disc cup disc ratio are measure with optical coherence tomography.
All patients will be placed into Arm 1. They will undergo punch biopsies of the breast skin at the time of mastectomy and at 2, 4, 6, 8 and 12 months after completion of radiation therapy. Three more biopsies will be taken at 3, 6, and 12 months after completion of reconstruction. Patients will also undergo skin blood flow studies with a laser imaging device prior to each biopsy procedure. Ultrasound studies of the chest vessels will be performed 4 times over the course of the study- once prior to radiation and at 2, 6 and 12 months after radiation.
The goal of this pilot study is to determine if a personalized trial (N-of-1) employing a Mind-Body Intervention (MBI) can produce a meaningful increase in sleep duration among women 40-60 years of age working at Northwell Health. A total of 60 women with a history of short sleep duration (defined as an average \<7h per 24-h period for at least three months) will be enrolled over a period of two years. Participants will complete a 2-week run-in period with no intervention, during which their baseline sleep duration and adherence to the Fitbit wear and survey submission will be assessed. Adherence to Fitbit wear will be defined as recorded activity of greater than 12 hours a day, and recorded sleeping activity greater than 180 minutes in total. Survey adherence will be defined as submission of a given survey. Participants who achieve at least 80% adherence of Fitbit wear and survey submission during baseline period will be randomized to Arm 1 (N=30) or Arm 2 (N=30). Each arm will receive a personalized intervention comprised of three components: mindfulness, yoga and guided walking assigned in 2-week block sequences for a total period of 12 weeks. During each 2-week block, participants will be prompted to complete 3 x 30-minute intervention sessions weekly. Interventions will be delivered by a virtual link to online videos recorded by an experienced wellness provider. Participants will be limited to three views of the study-provided intervention content each week. Changes in average daily sleep duration will be calculated for each participant based on daily measurements between the run-in and each treatment period. The Fitbit devices will also record sleep quality components (sleep onset, sleep staging, and overall sleep score) and physiological factors (breathing/resting heart rate, heart rate variability (HRV) and activity). We will also examine the direct and indirect relationships between perceived stress, anxiety and depression, and sleep quality assessed pre, during (bi-weekly), and post MBI. Enrollment will continue until up to 60 participants have been randomized. Following the intervention, all participants will be assessed over a 2-week follow-up period to allow for a personalized report of their observed data to be generated.
OBJECTIVE: To make recommendations for evaluation, approach to counseling and treatment for patients who present with ear fullness without abnormalities on otomicroscopic examination, standard audiometric studies, or imaging results.
METHODS: Retrospective chart review of adult patients in a tertiary referral center presenting with ear fullness and/or otalgia without external, middle, and/or inner ear pathologies. Data collected include demographics (age and gender), laterality and duration of symptoms, co-morbid conditions and final diagnoses of temporomandibular joint (TMJ) dysfunction, intermittent Eustachian tube dysfunction (iETD), migraine disorder, and anxiety.
RESULTS: In the span of 8 years of a single neurotologist's practice, 964 patients presented with ear fullness. After excluding all instances where external, middle, and inner ear disorders were identified and where audiometric and radiologic findings were abnormal, 263 patients had ear fullness and no objective causes. Women were more likely than men to complain of ear fullness and/or otalgia and were also more likely to present with no objective abnormalities ( p < 0.05). Patients who reported isolated ear fullness were more likely to be diagnosed with iETD, whereas patients who reported pain were more likely to be diagnosed with TMJ dysfunction (TMJD). Fourteen patients (5.3%) had completely unexplained sensation of ear fullness.
CONCLUSIONS: There were 94.7% of the patients presenting with unexplained ear fullness were diagnosed as having a possible contribution of TMJ dysfunction, IETD, migraine disorder, anxiety, or a combination of these conditions to their symptomatology. Directing treatments toward these diagnoses may alleviate symptoms of ear fullness or, if unsuccessful, provide an avenue for counseling in the framework of functional neurologic disorders.
NEW MATERIAL:The 5-fluorouracil derivative of formula (R is acyl derived from triene higher fatty acid or pentaene higher fatty acid). EXAMPLE:1-(alpha-Linoleylaminomethylcarbamoyl)-5-fluorouracil. USE:A carcinostatic agent and platelet coagulation inhibitor. PREPARATION:The objective compound of formula is produced by reacting 5-fluorouracil (5-FU) with the compound of formula R-NHCH2CO2H in a solvent such as dimethylformamide, dioxane, etc., in the presence of diphenylphos phorylazide. The compound exhibits an antitumor activity (carcinostatic activity) comparable to or higher than 5-FU, and has lower toxicity than 5-FU. It has strong platelet coagulation inhibiting activity which cannot be found in 5-FU. It is administered in a dose of preferably about 1-3g daily for adults.
PURPOSE: A composition containing whitening agent and sub-whitening agent is provided to enhance whitening function. CONSTITUTION: A composition for tooth whitening contains whitening agent and sub-whitening agent. The whitening agent is hydrogen peroxide. The sub-whitening agent is hyaluronic acid. The sub-whitening agent has adhesion property. The viscosity of the composition is 100,000-1,200,000 cps. A kit for tooth whitening contains the composition. A method for tooth whitening comprises a step of applying the composition onto the teeth.
Methods and apparatus for an intelligent human-machine interface comprising an interface shell, system agents, function agents, a dynamic documentation system, and a layering architecture. The system agents include dynamic, knowledge-based software object sub-agents that model and track the state of a work area. The function agents model, track, and facilitate work area functions. The interface shell provides a hardware and software interface between the system agents and the function agents. The layering architecture comprises a tracking layer, an equipment and supply management layer, a coordination layer, and a situational awareness layer, and an oversight layer. The oversight layer combines information from the situational awareness layer with process rule sets contained in the function agents to determine if processes are being performed correctly. The interface processes an integrated collection of facts and relationships and recognizes deviation from or compliance with a predetermined process and communicates the same to a user.
The invention designs a method for non-invasively measuring the hepatic portal vein pressure in biomedicine by using a fluid dynamics model. The invention aims to obtain the response of a hepatic portal vein position contrast agent to a subharmonic signal through ultrasound, and acquire the relation between an ultrasonic contrast microbubble and environmental pressure by using a fluid dynamics model. And correcting the fluid mechanics model by combining with an in vitro experiment. The aim of obtaining the hepatic portal vein pressure before the operation is fulfilled. The portal vein pressure measured by the method of the invention has the following advantages compared with the prior manometry method: the invention can acquire the hepatic portal vein pressure under the non-invasive condition, and creates a brand-new non-invasive measurement idea and method. Because the invention is a non-invasive manometry method, the bleeding risk of preoperative puncture manometry can be avoided. The invention utilizes the ultrasonic technology and the radiography technology, and has the advantages of simplicity, convenience and the like.
The prevalence rate of arthritis in medial knee joint is increasing with an increase in senile diseases and there are two main types of therapy: total knee replacement surgery and high tibial osteotomy. Generally, the elderly prefer total knee replacement surgery and younger people prefer high tibial osteotomy. High tibial osteotomy is a procedure to reduce pain and to prevent the progression of osteoarthritis by evenly dispersing excessive load on medial knee joint attributed to varus deformity on the overall knee joint through the correction of abnormal anatomical axis arising from degenerative changes in articular cartilage. The clinical outcomes of high tibial osteotomy are reported as favorable but this high tibial osteotomy has a limitation in terms of the regeneration of injured cartilage. Thus, a research to concurrently perform additional therapy for the regeneration of injured cartilage with the osteotomy was released. Microfracture surgery on injured cartilage, autologous chondrocyte implantation, autologous bone marrow injections and adipose derived stem cell injections are typical examples. However, there is not any solid proof for the excellence of concurrent therapy over a therapy using only the osteotomy in the regeneration of injured cartilage. Therefore, this research is designed to conduct a research to prove the excellence of the direct transplantation of stem cell into injured cartilage over the existing concurrent therapy in the regeneration of injured cartilage. Besides, this research intends to compare the cartilage regeneration capabilities of bone marrow and adipose-derived stem cell.
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a commonly performed type of bariatric surgery. Early complications of LSG include bleeding, leakage, pulmonary embolism, and surgical site infections. Most surgeons try to implement preventive methods, such as omentopexy. Staple line-imbrication, which has a difficult learning curve, often prevents complications. This study aimed to evaluate the effect of omentopexy on patients with imbricated LSG.
MATERIAL AND METHODS: The study applied a retrospective data analysis design to patients who underwent LSG between 2020 and 2023. All patients' staple lines were imbricated, and patients were then divided into two groups: omentopexy group and control group. Patients' demographic features, such as age, gender, height, weight, body mass index(BMI), bleeding, leakage, and reoperations, were recorded and examined retrospectively.
RESULTS: A total of 1356 patients were included in the study (540 in omentopexy, 816 in control), of which the mean age was 37.9 ± 10.5 years, 82.3% were women, and mean BMI was 40.9 ± 5.8 kg/m2. The mean bleeding rate was 1.0% (1.3-0.7%), the mean leakage rate was 0.2% (0.2-0.2%, respectively), and the mean reoperation rate was 0.6% (0.7% and 0.5%, respectively). No statistically significant differences were observed.
CONCLUSION: Omentopexy is a technique that is widely used to prevent staple line complications. According to our study, omentopexy applied to an imbricated stapler line increased the operation time but did not affect bleeding or leakage ratios. This is the first study to evaluate the effect of omentopexy on imbricated staple lines. The findings of the study indicate that omentopexy has no additional benefit on early complications when using staple-line imbrication.
PROBLEM TO BE SOLVED: To obtain a safe oral pharmaceutical composition for replenishing nutrients for physical fatigue, anorexia during or after diseases, nutritional disorders, pyrogenous marantic diseases, etc., and further for nourishment, robustness and improvement in weak constitution by combining two kinds of specific compounds. SOLUTION: This composition contains ubidecarenone and a vitamin B1 derivative. The vitamin B1 derivative is compounded in an amount of 0.2-10 pts.wt. (converted into vitamin B1 ) per pt.wt. of the ubidecarenone. The vitamin B1 derivative is thiamine or its salt, dicethiamine, fursulthiamine, etc., especially dicethiamine. The addition of taurine to the composition in an amount of 1-300 pts.wt. per pt.wt. of ubidecarenone is preferable from the point of effects.
Chronic neutrophil leukemia (CNL) is a rare and life-threatening disease. Cases of CNL combined with lymphoma are rare. Here, we report a case of CNL with T-acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) in a 28-year-old male. After a regimen of ruxolitinib, VICLP (Vincristine, Idarubicin, Cyclophosphamide, Prednisone, Peg-asparaginase) regimen, high-dose cytarabine, and methotrexate regimens, the patient's bone marrow condition partially resolved. However, when the disease relapsed four months later, despite attempts with selinexor, venetoclax, and CAG(aclarubicin hydrochloride, Algocytidine, Granulocyte Stimulating Factor) chemotherapy, the leukocytes and peripheral blood primitive cells reduced, but the bone marrow did not achieve remission. This pathogenesis may be related to microenvironmental immune escape under prolonged inflammatory stimulation and gene disruption affecting protein function due to colony-stimulating factor 3 receptor gene (CSF3R) mutations. For this type of disease, early intervention may delay disease progression.
PURPOSE: A manufacturing method of Cactus extracts having a superior solubility using a high pressure enzyme reaction is provided to manufacture the Cactus extracts by decomposing mucilage component, thereby increasing availability of the Cactus in food and medical fields. CONSTITUTION: A manufacturing method of Cactus extracts having a superior solubility using a high pressure enzyme reaction comprises the following steps: washing and grinding the Cactus(S1); adding a mixture including pectinase and hydrocarbonoclastic enzyme and distilled water to the grinded Cactus and performing the high pressure enzyme reaction thereof (S2); heat treating the reacted products obtained by performing the high pressure enzyme reaction and inactivating the enzyme(S3); and irradiating the reacted products with the ultra high frequency(S4). In S2 step, 0.5-2 parts by weight of the pectinase, 0.5-2 parts by weight of the hydrocarbonoclastic enzyme, and 5-15 parts by weight of distilled water are added to 100 parts by weight of the grinded Cactus. The pectinase is either pectin methyl esterase or pectinase. The hydrocarbonoclastic enzyme is a mixture including arabanase, cellulase, β-glucanase, hemicellulase, and xylanase. In S2 step, the high pressure enzyme reaction is processed at 32-40 deg. Celsius and 80-120 MPa for 1-24 hours. In S3 step, The enzyme inactivation process is heated in boiling water at 90-100 deg. Celsius for 10-15 hours. In S4 step, the ultra high frequency is irradiated for 2-3 minutes for 300g of the reactants.
Friedreich's Ataxia (FA) is a progressive neurodegenerative disease affecting 1 in 50,000 individuals in the U.S. Currently, there is no approved treatment.

There is a critical knowledge gap regarding the best ways to intervene to increase aerobic capacity (VO2max on exercise testing) in FA. Exercise is the most potent known stimulus for increasing muscle mass and mitochondrial oxidative phosphorylation (OXPHOS) capacity, increasing VO2max, and increasing insulin sensitivity (Si), however, it has not been studied in FA. One adaptation seen in exercised muscles is an increase in muscle nicotinamide adenine dinucleotide (NAD+), a cofactor required for glycolytic and mitochondrial adenosine triphosphate (ATP) production. In skeletal- and cardiac muscle-specific frataxin (FXN) knock-out animals, NAD+ precursors rescued cardiac function to near-normal, additionally highlighting its translational potential in FA. Nicotinamide riboside (NR) is a NAD+ precursor currently available as a dietary supplement (Tru Niagen ®, ChromaDex, Irvine CA) that is expected to be safe and well-tolerated in adults and children. The central hypothesis is that exercise + NR will increase skeletal muscle mitochondrial OXPHOS and increase muscle mass to increase VO2max in FA. The investigators expect that exercise + NR will also increase Si in this cohort.