anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always possible in postnatal pediatric HIV infections. The timing of ART initiation is likely to affect the size of the latent viral reservoir established, as well as the development of adaptive immune responses, such as the generation of neutralizing antibody responses against the virus. How these parameters impact the ability of infants to control viremia and the time to viral rebound after ART interruption is unclear and has never been modeled in infants. To investigate this question we used an infant nonhuman primate Simian/Human Immunodeficiency Virus (SHIV) infection model. Infant Rhesus macaques (RMs) were orally challenged with SHIV.C.CH505 375H dCT and either given ART at 4-7 days post-infection (early ART condition), at 2 weeks post-infection (intermediate ART condition), or at 8 weeks post-infection (late ART condition). These infants were then monitored for up to 60 months post-infection with serial viral load and immune measurements. To gain insight into early after analytic treatment interruption (ATI), we constructed mathematical models to investigate the effect of time of ART initiation in delaying viral rebound when treatment is interrupted, focusing on the relative contributions of latent reservoir size and autologous virus neutralizing antibody responses. We developed a stochastic mathematical model to investigate the joint effect of latent reservoir size, the autologous neutralizing antibody potency, and CD4+ T cell levels on the time to viral rebound for RMs rebounding up to 60 days post-ATI. We find that the latent reservoir size is an important determinant in explaining time to viral rebound in infant macaques by affecting the growth rate of the virus. The presence of neutralizing antibodies can also delay rebound, but we find this effect for high potency antibody responses only. Finally, we discuss the therapeutic implications of our findings.
Persons with type 1 diabetes are at a much greater risk for heart disease compared to the general population. Among individuals with diabetes, those with a specific variation in a genetic marker called Haptoglobin (approximately 43% of persons with type 1 diabetes) are at even greater risk compared to those not carrying this genetic variation. A genetic marker or a "gene" is information inherited from parents (a blueprint) about the structure and functions of cells in the body that make up the color of our hair and eyes and may influence the way our bodies respond to certain stimuli such as an illness, or infection.

In this project we are seeking to understand what some of the mechanisms may be that put persons with type 1 diabetes and this variation in the Haptoglobin gene at greater risk for heart disease. Specifically, we will assess whether this gene variant affects the function of the good cholesterol (HDL cholesterol) and its subfractions (via NMR spectroscopy), which is thought to help against heart disease development. We also seek to evaluate whether vitamin E supplements may improve this function. If results indicate that vitamin E is beneficial and improves the function of HDL cholesterol, the next question to be answered would be whether vitamin E would also help reduce the risk of heart disease itself in these persons. To answer the latter, a large clinical trial would have to take place. In this research project we will therefore also evaluate whether such a trial would be feasible and whether individuals with type 1 diabetes would be interested in participating in a long, 4-5 year, clinical trial.
Subjects use a violet light emitting lamp (device intervention - minimally invasive as it's simply a source of light) with CR-39 lenses for their refractive correction. The lamp introduces violet light (Violet +) and the CR-39 lenses allow for the transmission of violet light through the lenses (Lens +).
PURPOSE:To provide a mold lubricant by which when a hard resin jacket crown is formed a hardened material for the jacket crown can be readily released from a model of a gypsum support tooth and which is excellent in size adaptability to an initial support tooth and which forms no unpolymerized layer on the inner surface of the jacket. CONSTITUTION:A mold lubricant set is composed of a water emulsion of a polymer having rubber elasticity and a solution containing a carboxyl group or its salt. The water emulsion is applied to that portion of a gypsum support tooth which is located above a margin portion. The solution containing the carboxyl group or its salt is applied to the margin portion. Therefore, a film having rubber elasticity derived from the water emulsion intervenes between the inner surface of a jacket crown and a gypsum model and so a mold can be easily released after hardening. Since the film derived from the polymer having carboxyl group and applied to the margin portion is thin, the film is excellent in size adaptability and also no unpolymerized layer is formed on the inner surface of the jacket.
PURPOSE: To obtain a stable composition comprising a hair-dressing resin, dimethyl ether and water, short in a drying time, and useful for hair sprays, wherein the dimethyl ether and the water are contained in a specific ratio and wherein the resin is contained in such an effective amount that the resin is not precipitated. CONSTITUTION: This composition comprises one or more kinds of hair-dressing resins, dimethyl ether and water. Therein, the dimethyl ether and the water are contained in such a ratio of 0.5/1 or larger that are two phases are formed, and the hair-dressing resin is also contained in such an effective amount that the resin is not precipitated. The hair-dressing resin may be the mixture of a polar resin with a non-polar resin. The resin may be partially or perfectly neutralized with an alkali agent (e.g. an organic or inorganic base, such as 2-amino-2-methyl-1-propanol).
After thorough prophylaxis, place gel in applicator tray (not more than 1/3 full). Throughly air-dry teeth and insert tray(s) in mouth. Gel may also be swab applied. Instruct patient to bite down slightly but firmly for one to four minutes. A slight chewing motion enhances coverage interproximally. Remove tray(s) and have patient expectorate excess gel. Instruct patient not to eat, drink or rinse for at least 30 minutes.
An initial Baseline MRI is to be done within 6-24 hours from the bleeding. second MRI which serves as review - within two weeks.
PURPOSE: A method of producing a cosmetic composition containing a Corni Fructus extract having free radical scavenging properties, antioxidant action, anti-inflammatory properties, cell membrane protecting action, cell proliferating action, etc. is provided. The cosmetic composition has enhanced efficacy in preventing skin aging and safety to human body. CONSTITUTION: Fruit meat sections are separated from a whole fruit of Corni Fructus, added with an extraction solvent in a volume of 10 to 20 times based on the weight of dried meat of Corni Fructus and extracted for 2 to 20hr at 50 to 95deg.C in an extractor with a cooling condenser. Thereafter, the extract is filtered with a filter paper of 400meshes, cooled to room temperature and precipitated for 1 to 15 days at 5 to 15deg.C and filtered with a filter with a size of 0.3μm. The cosmetic composition contains 0.01 to 10%(w/v) of the Corni Fructus extract.
IL-10 is a key anti-inflammatory mediator ensuring the protection of a host from excessive inflammation in response to pathogen infections, whose transcription or expression levels are tightly linked to the onset and progression of infectious diseases. An AP-1 family member called CiJunD was shown to be a transcription factor of IL-10 in grass carp (Ctenopharyngodon idella) in the current study. CiJunD protein harbored the conserved Jun and bZIP domains. Mutant experiments demonstrated that CiJunD bound to three specific sites on IL-10 promoter, i.e., 5'-ATTATTCATA-3', 5'-AGATGAGACATCT-3', and 5'-ATTATTCATC-3', mainly relying on the bZIP domain, and initiated IL-10 transcription. Expression data from the grass carp spleen infected by Aeromonas hydrophila and lipopolysaccharide (LPS) challenged spleen leukocytes indicated that the expressions of CiJunD and IL-10 were positively correlated, while the expression of pro-inflammatory cytokines, such as IL-1β, IL-6, IL-8, IFN-γ, and TNF-α, showed an overall downward trend when CiJunD and IL-10 peaked. The ability of CiJunD to down-regulate the production of pro-inflammatory cytokines and up-regulate the expression of IL-10, both with and without LPS stimulation, was confirmed by overexpression experiments. Meanwhile, the subcellular fractionation assay revealed that the nuclear translocation of CiJunD was significantly enhanced after the LPS challenge. Moreover, in vivo administration of grass carp with Oxamflatin, a potent agonist of JunD activity, could promote IL-10 but suppress the expression of pro-inflammatory cytokines. Intriguingly, tissue inflammation lesions and the survival rates of grass carp infected with A. hydrophila were also significantly improved by Oxamflatin administration. This work sheds light on the regulation mechanism by JunD of IL-10 expression and bacterial infectious inflammation for the first time, and it may present a viable method for preventing infectious diseases in fish by regulating IL-10 expression and inflammatory response.
BACKGROUND: Previous longitudinal magnetic resonance imaging studies have shown progressive gray matter (GM) reduction during the earliest phases of schizophrenia. It is unknown whether these progressive processes are homogeneous in all groups of patients. One way to obtain more valid findings is to focus on the symptoms. Auditory hallucinations (AHs) are frequent and reliable symptoms of psychosis. The present study aims to analyze whether longitudinal changes in structural abnormalities in cortical regions are related to the presence of AHs and the intensity of psychotic symptoms in a large sample.
METHODS: A Magnetic Resonance (MR) voxel-based morphometry analysis was applied to a group of 128 first episodes psychosis (FEP) patients (63 patients with AHs and 65 patients without AHs) and 78 matched healthy controls at baseline and at a 2-year follow-up.
RESULTS: At baseline, FEP patients exhibited significant GM volume reductions in the temporal, frontal and precentral regions. At follow-up, FEP patients exhibited GM volume changes in the temporal, Rolandic, frontal, precentral and insula regions. At baseline, no significant differences were found between FEP patients with and without AHs. At follow-up, while FEP patients with AHs showed less GM volume in temporal and frontal lobes, non-AH FEP patients showed reductions in the frontal, precentral and fusiform areas. PANSS scores showed statistically significant correlations with GM volume reductions at baseline and follow-up.
CONCLUSIONS: Brain cortical loss in the early phases of psychosis is not associated with potentially transitory AHs; however, brain structural changes may emerge as AHs appear in chronic patients.
The invention relates to a composition for treating lymphoma. The composition is prepared from the following raw materials in parts by weight: 3-9 parts of scorpio, 2-5 parts of centipede, 10-20 parts of batryticated silkworm, 20-40 parts of buttercup root, 15-25 parts of bittersweet, 10-20 parts of euonymus alatus, 15-25 parts of rhizoma arisaematis and 10-15 parts of rhizoma pinelliae preparata. The composition is reasonable in prescription and accurate in lymphoma treatment effect. The invention further discloses a preparation method of the composition. The preparation method comprises the following steps of: adding ethanol in the scorpio, centipede and batryticated silkworm, moistening, and carrying out microwave drying the medicines; crushing the medicines to fine powder for future use; and decocting the buttercup root, bittersweet, euonymus alatus, rhizoma arisaematis and rhizoma pinelliae preparata in water, filtering, concentrating, carrying out spray drying, and uniformly mixing; and adding additives in the medicines to prepare pharmaceutically acceptable oral preparation. The preparation method can be used for guaranteeing convenient use and controllable quality of the composition.
Subjects will follow the exercise regime during four days. Each day will consist of 13 hours sitting, 1 hour walking, 1 hour standing, 1 hour exercise and 8 hours sleeping. The cycle session will be at approximately 60% maximal power. Exact cycling intensity and duration will be calculated to ensure equal total energy expenditure between the sitting less and the exercise regime.
A kit of individual packets of food containing a dosage amount of an allergen. The kit has a plurality of packets associated with each other and containing a carrier food in each packet and an allergen so arranged that the respective allergen quantity in each successive packet is larger than in the previous packet. Preferably, the allergen quantities are different and range in weight from 100mg to 1800mg in 7 packets. Preferably, each kit has about the same total weight which is in the range of about 3mg to 4mg. The contents of each package can be fed to an infant by being dissolved in mother's milk, formula and the like. After the initial introduction packets, maintenance packets, preferably containing 2mg of the allergen can be fed to the child.
Patients who have a yes-no reversal respond "yes" when they mean no and vice versa. The unintentional response can be made both verbally and with gestures (e.g., head shake or nod, thumbs up or down). Preliminary reports associate this phenomenon with 4-repeat tauopathies including primary progressive apraxia of speech (PPAOS), nonfluent/agrammatic primary progressive aphasia, and corticobasal syndrome; however, the significance and timing of this symptom relative to others are not well understood. Whereas some accounts associate yes-no reversals with other binary reversals (e.g., up/down, hot/cold) and attribute the reversals to disturbances of selection within the language system, others implicate more general inhibitory control processes. Here, we compared clinical and neuroimaging findings across 30 patients with PPAOS (apraxia of speech in the absence of aphasia), 15 of whom had a yes-no reversal complaint and 15 who did not. The two groups did not differ on any of the language or motor speech measures; however, patients who had the yes-no reversal received lower scores on the Frontal Assessment Battery and motor assessments. They also had greater hypometabolism in the left supplementary motor area and bilateral caudate nuclei on [18F]-fluorodeoxyglucose PET, but only the right caudate nucleus cluster survived correction for multiple comparisons. We interpret these results to suggest that the yes-no reversal phenomenon is associated with cognitive abilities that are supported by the frontostriatal network; more specifically, impaired response inhibition.
This is a prospective, non-therapeutic protocol designed to create and maintain a registry of participants with Adrenoleukodystrophy (ALD) and known/presumed mutation for ALD. This study also involves maintaining a prospective biorepository to collect and store buccal swab, blood, stool and urine samples as well. In this protocol, pediatric (including infants), adolescents and adult patients with confirmed or presumed ALD (based on positive VLCFA testing and/or confirmed mutation) will be offered potential study participation. Additionally, presumed mutation for ALD (based on pedigree or confirmed mutation) will be offered potential study participation. After appropriate consent (online or in-person), subjects will be requested to provide a medical history (with authorization of release of medical records), longitudinal biospecimens, and permission to perform laboratory analyses on these samples. The overall goal is to understand the natural disease course in affected and unaffected patients (identified patients and relatives with a diagnosis of ALD), as well as women with ALD to assemble a resource of clinical, medical, and biological data from the participants. This study also aims to understand the outcomes of this disease, as well as possibly develop biomarkers to identify prognostic markers for disease progression, which may help develop effective interventions. The biospecimen bank and registry will provide access to samples and data for the ongoing studies as well as will provide an important resource for the future research.
Composition in aqueous solution, comprises insulin and substituted anionic compounds, which consist of a backbone formed by a discrete number (u) of 1-8 of identical or different saccharide units, linked by identical or different glycosidic bonds. The saccharide units consist of hexoses in cyclic form or open reduced form. The substituted anionic compounds comprise partially substituted carboxyl functional groups and unsubstituted carboxyl functional groups that are salifiable. Independent claims are included for: (1) pharmaceutical formulation comprising a composition in aqueous solution; (2) use of anionic functionalized compound for preparing pharmaceutical insulin formulation, after administration, to accelerate passage of blood insulin and to reduce blood sugar faster relative to a formulation free of anionic substituted compound; and (3) preparing formulation of human insulin and insulin analog whose onset of action in humans is lower than that of the reference formulation in the same concentration of insulin in the absence of anionic substituted compound, comprising adding an anionic compound to the formulation. ACTIVITY : Antidiabetic. MECHANISM OF ACTION : None given.
1,160,235. Detergent compositions; aerosol compositions. L'OREAL. 5 Oct., 1966 [5 Oct., 1965; 14 Jan., 1966], No. 44536/66. Headings C4X and C5D. [Also in Division D1] Aerosol compositions and detergent compositions for use in the treatment of hair comprise a basic composition comprising a mixture of at least one thiol and at least one disulphide of a thiol the mole ratio of disulphide to thiol being at least 1À5: 1. The thiol may be thioglycollic acid, thioglycerol, glycol thioglycollate, glycerol thioglycollate, glycol thiolaetate, #- mercaptoethanol, N-carboxymethyl-mercaptoacetamide, thiolactic acid or #-mercaptopropionic acid and the disulphide of a thiol may be a disulphide of one of these thiols although not necessarily the disulphide of the thiol being used. The pH of the composition may be adjusted, preferably to a pH of 9-10, by the addition of ammonia, sodium carbonate, monoethanolamine, diethanolamine or morpholine. The composition may be in the form of a liquid solution, cream or gel. Aerosol compositions may contain butane and Freon (Trade Mark). Shampoos may contain compounds containing polyethenoxy groups, sugar esters, lauryl sulphates, dodecyl benzene sulphonate, quaternary ammonium salts, salts of fatty amines or long chain amino acids, and may comprise 2-10% by weight of detergent 0À5-10% by weight of thiol and 3-50% by weight of thiol disulphide. The compositions may also contain perfumes, dyes, cationic products which facilitate the untangling of the hair and the application of the composition, swelling agents, e.g. urea, or sequestering agents.
A medical device data back-association system, apparatuses, and methods are disclosed. In an example embodiment, an electronic medical record memory receives, while an infusion pump is administering a medication to a patient, an identifier message including at least two of a device identifier of the infusion pump, a patient identifier of the patient, and a medication order identifier of a medication being administer by the infusion pump. The memory creates an association between an electronic medical record (“EMR”) of the patient and the infusion pump using the identifier message. The memory next receives, after the association between the EMR of the patient and the infusion pump, infusion pump data from the infusion pump. The infusion pump data includes the device identifier. The memory then stores the infusion pump data to the EMR of the patient based on the created association between the EMR of the patient and the infusion pump.
Laser Interstitial Thermal Therapy (LITT) ablations are neurosurgical procedures which are performed for several indications including brain tumors and epilepsy. LITT procedures are performed utilizing intraoperative magnetic resonance imaging (MRI) scans. Some of these procedures must be performed in the prone position and can last 8 hours or longer. Investigators have observed several minor skin breakdown complications as well as a few major thromboembolic complications during these long prone procedures. Investigators hypothesize that the cause of the major thromboembolic complications are a result of compression of the femoral veins by the gel pads used to support the patient in the prone position. Many long spine surgeries are performed in the prone position and fewer episodes of skin pressure wounds are experienced and no major intraoperative thromboembolic complications. The study team hypothesizes that the difference is the way that the spine surgery pads support the hips does not compress the femoral vein, therefore significantly decreasing the risk of developing a thrombus intraoperatively.

The aim of this project is to design a modular, adjustable plastic frame to support the spine surgery Jackson table chest and hip pads. Investigators will produce a prototype of the frame and test it during LITT procedures. The prototype of the frame will be 3D printed using the 3D printer owned by the Department of Neurosurgery. The hypothesis is that supporting the patient in the prone position using similar positioning methods to those used for spine surgeries will reduce the rate of skin pressure injuries and prevent future major thromboembolic complications.
Participants will receive free access to the ZI app for the 12-week intervention. After completing initial set-up, participants will be asked to record physical activity and symptoms regularly via scheduled in-app routines. Further use of ZI (eg. Custom daily routines, additional graphing, medication tracking, accessing linked health resources) during the intervention will be possible ad libitum. After the initial 12-weeks of the EXCEL+ZI intervention, participants have continued free access to the ZI app for up to 1 year.
MOTIVATION: Exploring potential associations between diseases can help in understanding pathological mechanisms of diseases and facilitating the discovery of candidate biomarkers and drug targets, thereby promoting disease diagnosis and treatment. Some computational methods have been proposed for measuring disease similarity. However, these methods describe diseases without considering their latent multi-molecule regulation and valuable supervision signal, resulting in limited biological interpretability and efficiency to capture association patterns.
RESULTS: In this study, we propose a new computational method named DiSMVC. Different from existing predictors, DiSMVC designs a supervised graph collaborative framework to measure disease similarity. Multiple bio-entity associations related to genes and miRNAs are integrated via cross-view graph contrastive learning to extract informative disease representation, and then association pattern joint learning is implemented to compute disease similarity by incorporating phenotype-annotated disease associations. The experimental results show that DiSMVC can draw discriminative characteristics for disease pairs, and outperform other state-of-the-art methods. As a result, DiSMVC is a promising method for predicting disease associations with molecular interpretability.
AVAILABILITY AND IMPLEMENTATION: Datasets and source codes are available at https://github.com/Biohang/DiSMVC.