anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The impingement-free ROM in a RSA patient is defined as the rotational area the humeral liner can move through without colliding against the scapula or dislocating the joint. In a previous study, a new software model was developed that uses imaging data to compute and quantify the impingement-free ROM of a patient according to clinically relevant motions. Before this model can be used in clinical practice, a validation of the model's accuracy in predicting real RSA patient outcomes is required. Therefore, the first objective is to verify the model's ability to predict the ROM of the glenohumeral joint in real RSA patients. The investigators will investigate and quantify the ROM and joint angles of RSA patients with and without impingement with the help of EOS imaging and video motion analysis. The investigators can then compare model outputs with measured patient outcomes. Additionally, the investigators will investigate how well our software model can predict impingement in patients with known postoperative impingement.

Currently, the software model uses a database of healthy shoulder kinematic motions to produce an objective ROM score for a RSA. However, it is not known if healthy shoulder kinematics are a suitable reference for quantifying and interpreting RSA kinematics. Glenohumeral motions of healthy subjects are already extensively described by Ludewig et al. Glenohumeral motions of RSA patients are not yet reported. Also, little is known about muscle activation patterns in RSA patients. The second objective is to describe muscle activation patterns and shoulder kinematics of RSA patients and compare our measured RSA kinematic motions to the healthy kinematic motion data currently used in the software model. Therefore, the investigators will perform instrumented 3D motion analysis in conjunction with electromyography measurements to incorporate muscle activation patterns into our RSA glenohumeral motion analysis. Our additional sub-objective is to compare muscle activation patterns between patients with and without limited ROM, with the goal of identifying differences between the two groups.

The third objective is to identify patient-related and implant related factors that influence the ROM after a reversed shoulder arthroplasty. Therefore, the investigators will investigate clinical factors that could have effect on the ROM after RSA. The different factors (sex, birth year, Body Mass Index, generic score EQ-5D-3L, Tampa Schaal voor kinesofobia) will be analyzed both across and within patients with and without limited ROM with the goal of identifying their relation to ROM. The most important implanted related factor will also be investigated and analyzed both across and within groups: implant position in terms of glenoid component version, inclination and location of center of rotation.
PROBLEM TO BE SOLVED: To efficiently improve the precision of diagnosis by providing an information system which records medical treatment information at the time of medical treatment in a patient card which functions as a clinical recording and an individual holds with a portable recording medium and can refer to past record even in other hospitals later. SOLUTION: In a hospital A a medical image diagnosis unit 1, an image server 2 and two electronic clinical recording devices 3, and in a hospital B the device 3 are connected to LANs in the respective hospitals. LAN 4 of the hospitals A and B are connected by the Internet 5. The respective devices 3 operate when the patient cards 6 as the clinical recordings, which the patients themselves have, are inserted. The server 2 and the device 3 of the hospital A transmit data in accordance with a request from the device 3 of the hospital B. A picture which the diagnosis unit 1 takes is transferred to the server 2 through a network or MOD and a magneto-optical disk. Thus, basic information and the past consultation history of the patient are referred to and the precision of diagnosis and the quality of medical treatment can efficiently be improved.
The randomization will be done with a list generated by the central pharmacy of the Hospital das Clínicas, Medical School, USP. When randomized to the placebo oral tablets group, the patient will receive placebo (orally, 2 single dose tablets) also 2 hours prior to PCI.
<P>PROBLEM TO BE SOLVED: To provide a drug for preventing development of hepatic diseases used for a simple and effective prophylactic method or therapeutic method by which the development of the hepatic diseases can be prevented without progressing to serious hepatic diseases such as hepatoma even when persistently infected with HCV (hepatitis C virus).  <P>SOLUTION: The drug for preventing the development of the hepatic diseases includes an inhibitor of peroxisome proliferator-activated receptor α and the persistent activation of the receptor is thereby inhibited or reduced and suppressed. As a result, the development of HCV persistent infection-induced hepatic diseases is subjected to prophylaxis, suppression, and/or delay and prevented. The drug for preventing the development of the hepatic diseases includes a fatty liver ameliorating agent for carrying out the prophylaxis, the suppression, and/or the delay of the development of the fatty liver and/or etiologic symptoms thereof and the fatty liver ameliorating agent provides the prophylaxis, the suppression, and/or the delay of the development of the fatty liver and/or the etiologic symptoms thereof. Thereby, the development of the HCV persistent infection-induced hepatic diseases is subjected to the prophylaxis, the suppression, and/or the delay and prevented.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Provided is a method for dyeing hair that has, in this order: a step (I) in which an agent A, containing a component (A1) and a component (A2) ((A1) is a compound represented by general formula (1) or a salt thereof [In the formula, the dashed line indicates the presence or absence of a π bond. R 1  represents a hydroxyl group or an acetoxy group. R 2  represents a hydrogen atom or -COOR (R represents a hydrogen atom, a methyl group, or an ethyl group). R 3  represents a hydrogen atom, an acetyl group, a methyl group, or an ethyl group.] and (A2) is an alkali agent.) is mixed with an agent B, containing a component (B1) and a component (B2) ((B1) is an oxidative dye other than the component (A1) and (B2) is an alkali agent.) before use and a hair dye composition is prepared; and a step (II) in which the hair dye composition is applied to hair. The mixture ratio of the agent A and the agent B in step (I) is a predetermined ratio and there is no step in which an oxidizer is applied to the hair.
Whole-genome QTL mining and meta-analysis in tomato for resistance to bacterial and fungal diseases identified 73 meta-QTL regions with significantly refined/reduced confidence intervals. Tomato production is affected by a range of biotic stressors, causing yield losses and quality reductions. While sources of genetic resistance to many tomato diseases have been identified and characterized, stability of the resistance genes or quantitative trait loci (QTLs) across the resources has not been determined. Here, we examined 491 QTLs previously reported for resistance to tomato diseases in 40 independent studies and 54 unique mapping populations. We identified 29 meta-QTLs (MQTLs) for resistance to bacterial pathogens and 44 MQTLs for resistance to fungal pathogens, and were able to reduce the average confidence interval (CI) of the QTLs by 4.1-fold and 6.7-fold, respectively, compared to the average CI of the original QTLs. The corresponding physical length of the CIs of MQTLs ranged from 56 kb to 6.37 Mb, with a median of 921 kb, of which 27% had a CI lower than 500 kb and 53% had a CI lower than 1 Mb. Comparison of defense responses between tomato and Arabidopsis highlighted 73 orthologous genes in the MQTL regions, which were putatively determined to be involved in defense against bacterial and fungal diseases. Intriguingly, multiple genes were identified in some MQTL regions that are implicated in plant defense responses, including PR-P2, NDR1, PDF1.2, Pip1, SNI1, PTI5, NSL1, DND1, CAD1, SlACO, DAD1, SlPAL, Ph-3, EDS5/SID1, CHI-B/PR-3, Ph-5, ETR1, WRKY29, and WRKY25. Further, we identified a number of candidate resistance genes in the MQTL regions that can be useful for both marker/gene-assisted breeding as well as cloning and genetic transformation.
Patients will receive 4 blinded infusions of BCD-217 plus Placebo. Starting with the fith infusion patients will receive unblinded BCD-100 monotherapy.
The invention discloses a preparation method of syringa pubescens solid instant tea having antibacterial and antivirus functions. The solid instant tea is prepared from the following raw materials in percentage by mass: 60-70% of syringa pubescens and 30-40% of honeysuckle. The preparation method comprises the following steps: preprocessing the syringa pubescens, preprocessing the honeysuckle, extracting and condensing active ingredients, preparing solid instant tea, etc. The preparation method of syringa pubescens solid instant tea disclosed by the invention is simple in process, convenient to store and carry, and convenient to use. The finished solid instant tea derives from pure natural resource, and is mainly prepared from medicinal and dietary raw materials; therefore, the solid instant tea has obvious antibacterial and antivirus effects, and is free from toxic and side effects to a human body and capable of effectively relieving sphagitis, tonsillitis, enterogastritis and inflammation caused by cold; the solid instant tea, in daily drinking, can further better prevent inflammation such as cold, sphagitis, tonsillitis and enterogastritis, and is suitable for patients suffering from pharyngitis and having poor constitution to drink in long time. And the brewed tea is golden in color, intense in aroma, pure, natural and relatively good in taste.
ABSTRACT  The present disclosure provides a method and system for detecting anomaly in the signal using a morphological aware symbolic representation of the signal. The method thus treat the problem of relevant information loss during the symbolic representation of the signal.  The system discovers pattern atoms based on the strictly increasing and strictly decreasing characteristics of the time series physiological signal, and generate symbolic representation in terms of these pattern atoms.  Additionally the method possess more generalization capability in terms of granularity. This detects discord / abnormal phenomena with consistency.   Date Recue/Date Received 2021-06-16
This group consists of 250 healthy male adults whose pelvic CT scans were analyzed to define the optimal antegrade entry point and anatomical parameters for anterior column fixation. The fluoroscopic visualization technique and screw placement were simulated to assess anatomical variations and feasibility specific to the male cohort.
Patients with lower than expected cyclosporine blood trough concentrations in relation to the oral dose of Sandimmune® may have poor or inconsistent absorption of cyclosporine from Sandimmune®. After conversion to Gengraf® Oral Solution (cyclosporine oral solution, USP [MODIFIED]), patients tend to have higher cyclosporine concentrations. Due to the increase in bioavailability of cyclosporine following conversion to Gengraf®, the cyclosporine blood trough concentration may exceed the target range. Particular caution should be exercised when converting patients to Gengraf® at doses greater than 10 mg/kg/day. The dose of Gengraf® should be titrated individually based on cyclosporine trough concentrations, tolerability, and clinical response. In this population the cyclosporine blood trough concentration should be measured more frequently, at least twice a week (daily, if initial dose exceeds 10 mg/kg/day) until the concentration stabilizes within the desired range.
STUDY OBJECTIVES: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Associations of baseline resting-state electroencephalography (EEG) with phenoconversion have been reported. In this study, we aimed to develop machine learning models to predict phenoconversion time and subtype using baseline EEG features in patients with iRBD.
METHODS: At baseline, resting-state EEG and neurological assessments were performed on patients with iRBD. Calculated EEG features included spectral power, weighted phase lag index, and Shannon entropy. Three models were used for survival prediction, and four models were used for α-synucleinopathy subtype prediction. The models were externally validated using data from a different institution.
RESULTS: A total of 236 iRBD patients were followed up for up to 8 years (mean 3.5 years), and 31 patients converted to α-synucleinopathies (16 PD, 9 DLB, 6 MSA). The best model for survival prediction was the random survival forest model with an integrated Brier score of 0.114 and a concordance index of 0.775. The K-nearest neighbor model was the best model for subtype prediction with an area under the receiver operating characteristic curve of 0.901. Slowing of the EEG was an important feature for both models.
CONCLUSIONS: Machine learning models using baseline EEG features can be used to predict phenoconversion time and its subtype in patients with iRBD. Further research including large sample data from many countries is needed to make a more robust model.
PURPOSE:To cure a person of a malignant tumor by separating blood plasma from blood, treating the blood plasma in contact with a blood plasma treating liquid, mixing the blood plasma with blood corpuscle components and returning the blood in a living body. CONSTITUTION:Blood from an artery 51 of a living body such as a house rabbit 5 or the like is sent to a blood plasma separating means 1 by a reflux means 600 such as a pump 61, a tube 71 and so on to separate a part of blood plasma. The residual blood plasma and blood corpuscle components are sent to a mixing means 3 through a tube 72. On the other hand, the separated blood plasma is passed through a tube 74 and supplied by a pump 62 to a blood plasma treating means 200 to be in contact with a blood plasma treating liquid and be sent to a mixing means 3. The blood plasma and blood corpuscle mixed by the mixing means 3, that is, the blood is adjusted to the environment in the living body by an adjusting means 400 and returned into the living body through a vein 54 by reflux means 600 such as a pump 63, a tube 73 and so on. The artery 51 of the living body and the vein 54 of the living body are suitably connected to an external circulating circuit by an injection needle or the like.
Ferroptosis, a lipid peroxidation- and iron-mediated type of regulated cell death, relates to both neuroinflammation, which is common in relapsing-remitting multiple sclerosis (RRMS), and neurodegeneration, which is prevalent in progressive (P)MS. Currently, findings related to the molecular markers proposed in this paper in patients are scarce. We analyzed circulatory molecular indicators of the main ferroptosis-related processes, comprising lipid peroxidation (malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and hexanoyl-lysine adduct (HEL)), glutathione-related antioxidant defense (total glutathione (reduced (GSH) and oxidized (GSSG)) and glutathione peroxidase 4 (GPX4)), and iron metabolism (iron, transferrin and ferritin) to estimate their contributions to the clinical manifestation of MS and differences between RRMS and PMS disease course. In 153 patients with RRMS and 69 with PMS, plasma/serum lipid peroxidation indicators and glutathione were quantified using ELISA and colorimetric reactions, respectively. Iron serum concentrations were determined using spectrophotometry, and transferrin and ferritin were determined using immunoturbidimetry. Compared to those with RRMS, patients with PMS had decreased 4-HNE (median, 1368.42 vs. 1580.17 pg/mL; p = 0.03). Interactive effects of MS course (RRMS/PMS) and disease-modifying therapy status on MDA (p = 0.009) and HEL (p = 0.02) levels were detected. In addition, the interaction of disease course and self-reported fatigue revealed significant impacts on 4-HNE levels (p = 0.01) and the GSH/GSSG ratio (p = 0.04). The results also show an association of MS course (p = 0.03) and EDSS (p = 0.04) with GSH levels. No significant changes were observed in the serum concentrations of iron metabolism indicators between the two patient groups (p > 0.05). We suggest circulatory 4-HNE as an important parameter related to differences between RRMS and PMS. Significant interactions of MS course and other clinically relevant parameters with changes in redox processes associated with ferroptosis support the further investigation of MS with a larger sample while taking into account both circulatory and central nervous system estimation.
PURPOSE:A health tea containing Gynostemma pentaphyllum Makino and Litchi chinensis Sonnerat as essential components. CONSTITUTION:A health tea containing Gynostemma pentaphyllum Makino (a veinous perennial herb which is a plant of the family Cucurbitaceae having a light sweetness) and Litchi chinensis Sonnerat (a mushroom, belonging to the family Polyporaceae, useful as an ameliorant remedy for hepatic function, and capable of giving a hot water extract having anticancer action) as essential components. The resultant tea is capable of increasing the metabolism promotion effect of the Gynostemma pentaphyllum Makino on lipoperoxide and the improvement in obesity of Litchi chinensis Sonnerat, and the increasing effect on hepatic function of the Litchi pentaphyllum Makino is obtained with eliminated bitterness of the Litchi chinensis Sonnerat. The Gynostemma pentaphyllum Makino to be used is preferably obtained by drying and powdering all sites, the terrestrial site, subterranean site or seed thereof. All the dried or dried and pulverized materials of the Litchi chinensis Sonnerat belonging to the so-called Ganoderma lucidum Karst. may be used. The amounts of the components to be incorporated may be as follows: 100:2-20 dried material weight ratio between the former and the latter.
The role of an extended pelvic lymph node dissection (ePLND) in patients undergoing radical prostatectomy (RP) remains controversial. An ePLND is the most accurate staging method to assess the presence of lymph node metastases. Lymph node involvement is associated with a significantly worse prognosis and may require immediate or delayed adjuvant therapy. However, an ePLND is associated with an increased risk of complications such as lymphoceles, thromboses and lymphedema, and prolongs surgery and patient recovery. Thus, the diagnostic advantage of PLND should be weighed against the potential morbidity.

The therapeutic value of an ePLND remains especially unclear in PCa patients with an estimated risk of lymph node invasion (LNI) ≤ 20%, where only a minority of patients will have nodes harbouring metastases. Prospective trials to address this issue are still lacking.
The Selective Serotonin Reuptake Inhibitor ("SSRI") group will receive medication for 12 weeks. Patients will be evaluated every 4 weeks and phone call will be made in between visits to assess the effectiveness and side effects of the medication. Questionnaires will be repeated in the clinic visits and will be used in the data analysis to look for improvements and to compare the two classes of medication in this study.
The invention belongs to the field of medicines, and particularly discloses application of myricetin. Application of myricetin in preparation of preparations for inhibiting PDGFR beta phosphorylation and/or PDGFR beta downstream pathway expression. Application of myricetin in preparing preparation for inhibiting smooth muscle phenotype transformation is provided. Application of myricetin in preparing medicine for preventing and treating diseases induced by smooth muscle phenotype transformation is provided. Application of myricetin in preparing medicine for preventing and treating cardiovascular diseases is provided. Application of myricetin in preparation of preparations for inhibiting PDGFR beta phosphorylation and/or PDGFR beta downstream pathway expression. Application of myricetin in preparing preparation for inhibiting PDGF-BB induced cell proliferation is provided. The invention discloses that myricetin has an inhibition effect on PDGFR beta, so that myricetin can inhibit smooth muscle phenotype transformation, thereby preventing and/or treating restenosis after vascular injury.
Prior to injection, patients will wait in a temperature controlled room for 30 minutes in order to allow time for normalization of baseline digital temperature. Once a patient is randomly selected via our randomization process, BT will be reconstituted by clinic nursing staff with sterile saline per manufacturer recommendations such that the investigating hand surgeon who will be performing the injection will be sufficiently blinded. After proper cleansing of the skin with alcohol swabs, BT will be sterilely administered percutaneously via a small-gauge needle and syringe into the base of each digit by the investigating hand surgeons within the Upper Extremity Division. The volar metacarpal head will be used as a standardized anatomic landmark for injection both to lessen the probability and magnitude of risk to deep structures of the hand as well as maximize probability of proper anatomic placement of the drug.
A salt of cytisine, selected from a mesylate salt of cytisine, a gentisate salt of cytisine; and a maleate salt of cytisine. Cytisine is a potent nicotinic acetylcholine receptor (nAChR) and the cytisine salts of the invention are for use in the treatment of nicotine addiction. Cytisine mesylate, cytisine gentisate and cytisine maleate have improved stability over the cytisine free base. A process for preparing the cytisine salts is also claimed, the method comprising preparing a first solution of an acid salt former selected from methanesulphonic acid, gentisic acid and maleic acid; preparing a second solution, of cytisine; adding the solution of acid salt former to the solution of cytisine; maintaining the resulting solution at an elevated temperature; cooling the solution and obtaining the solid cytisine salt by filtration. Also claimed are a pharmaceutical composition comprising cytisine mesylate, cytisine gentisate or cytisine maleate and a carrier. Also disclosed is a method of treating nicotine addiction in a subject by administering cytisine mesylate, cytisine gentisate or cytisine maleate.
Vagal nerve stimulation at an intensity under 10 units. Participants will self-administered at this intensity for 2 minutes each day over 4 weeks.
The first stage is a dose escalation study, with three CD70 CAR-NK dose levels. Each dose level is planned to recruit 3 to 6 subjects to evaluate safety and efficacy and determine the number of CD70 CAR-NK cells for treatment in the second stage. The second stage is the dose expansion stage, where 30 subjects are recruited to receive the number of CD70 CAR-NK cells recommended in the first stage.
Matched controls from the DANBIO register receiving standard routine care. Up to 3 patients will be matched based on sex, age (+/-5 years), time at enrolment (\< 2 years prior to index date is allowed) and DAS28 scores (+/- 0.4).