anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to daily chemical industry, in particular to a plant polypeptide nursing composition. A plant polypeptide nursing composition comprises 3-8 parts of active peptide and 3-7 parts of plant extract in parts by weight. The plant polypeptide care solution prepared from the plant polypeptide care composition has higher permeability, is easier to absorb by a human body, improves the antibacterial and anti-inflammatory effects, enables the menthol to emit fragrance more stably and durably, and improves the taste of the product. In addition, the product improves the effect of preventing irregular teeth, reduces the irritation of the product, and can effectively relieve oral problems such as gingival bleeding, stomatitis, halitosis, etc.; the oral care liquid can also effectively eliminate the bacterial breeding of tongue coating and periodontal, clean teeth, relieve halitosis, inhibit bacteria and resist inflammation, belongs to an effective oral care liquid, and can be used as a daily oral care product for a long time. The oral cavity pathogenic bacteria are removed by insisting on using the oral cavity health care product, and the oral cavity is healthier.
Aim 1 over 6 months will demonstrate ASIS device's consistent performance on 60 adult subjects with Cervical Dystonia. Gadolinium will be injected with ASIS subdermally (30) or conventional intramuscularly (30) for these 7 muscle groups: Splenius, Scalene, Sterno-cleido-mastoid, Levator scapulae, Semispinalis, Trapezius, and Longissimus. An MRI will be taken promptly after Gadolinium injection, as starting reference, to which subsequent MRI taken at 6 hrs, 12 hrs, and 24 hrs later will be compared for Persistent %. Since there isn't a way to measure level of Gadolinium within it, or any other (e.g. Botox) for that matter, at least the Prolongation of Gadolinium may be approximated by the greater or longer Persistent % on MRI. However, this approximation can only work if the variables are minimized to the same population with Cervical Dystonia, and these particular 7 muscle groups. Case in point, patients with Cervical Dystonia presumably have hyperactive Splenius, Scalene, Sterno-cleido-mastoid, Levator scapulae, Semispinalis, Trapezius, and Longissimus muscles, so expectantly will have shortened Gadolinium intramuscularly Persistent %, and somewhat reduced Gadolinium subdermally Persistent % as well due to agitation, thus these Persistent % values in Cervical Dystonia patients will not be like those of normal patients, or even the same between these 7 different muscle groups. Therefore, the Relative Prolongation Ability Score or total Persistent % subdermally over total Persistent % intramuscularly, will be specific and valuable indicators to help us modify Botox dosage and duration to inject into "unknown" subdermal bloodless space for Aim 2.

Aim 2 over 12 months, using Botox, instead of Gadolinium, will demonstrate the advantages of ASIS device subdermally over intramuscularly, for the same 60 adult subjects with Cervical Dystonia, on these particular 7 muscle groups: Splenius, Scalene, Sterno-cleido-mastoid, Levator scapulae, Semispinalis, Trapezius, and Longissimus. Hypothetically speaking, if that subdermal bloodless space in patients with e.g., Cervical Dystonia somehow failed to show prolongation of half-life for Gadolinium in Aim 1, we can still proceed with primary interest being therapeutic comparison for Botox in Aim 2, in terms of improvement on the Physician Global Assessment Scale at 6, 12, 18, 24, and 30 weeks, and reduction in Cervical Dystonia Severity Scale (CDSS) as well as adverse reactions.
Systems and methods for data warehouse management for medical information is provided. The system receives a set of medical record documents. These documents include evidence for one or more findings which are identified using natural language processing of evidence. The data set is probabilistically transformed into a structured data set (often as a table). This structured data set includes embedded links that reference the source document where the evidence is located. If the finding is supported by multiple articles of evidence, the link will direct the user to the source document with the highest confidence ranking. Evidence in the source document is highlighted and may include associated annotations. Evidence, findings and annotations may be updated by the user.
BACKGROUND: Mesenchymal stem cells have been administered via direct injection to treat perianal Crohn's fistulizing disease. We herein sought to determine the safety and durability of treatment response to 12 months with 3 individual phase IB/IIA clinical trials of mesenchymal stem cells for refractory perianal, rectovaginal, and ileal pouch fistulas in the setting of Crohn disease.
METHODS: Three phase IB/IIA randomized placebo-controlled single-blinded clinical trials were performed for (1) perianal fistulas, (2) rectovaginal fistula, and (3) ileal pouch in situ with anovaginal and/or perianal fistulas. Bone marrow-derived mesenchymal stem cells (75 million in 7.5 mL) were injected at the time of exam under anesthesia on day 0 and month 3. Outcome measures were adverse events and combined clinical and pelvic magnetic resonance imaging healing at month 6 and month 12.
RESULTS: Across all 3 trials, 64 patients were enrolled; 49 were treatment and 15 were control. At 6 months, combined clinical and radiographic healing was achieved in 83.3%, 33.3%, and 30.8% of the perianal, rectovaginal, and pouch fistula treatment cohorts, respectively. At 12 months, the treatment response was durable, with 67.7% of perianal, 37.5% of rectovaginal, and 46.2% of peripouch fistulas maintaining complete clinical and radiographic healing. Two patients in the perianal fistula control cohort achieved combined clinical and radiographic healing at 12 months, whereas 0% of rectovaginal and pouch control patients healed.
CONCLUSION: Bone marrow-derived mesenchymal stem cells offer a safe and effective alternative treatment approach for severe perianal, rectovaginal, and peripouch fistulizing Crohn's disease. Treatment results are durable at 12 months.
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after blister formation. Specifically, using the blister tops, we are able to enrich for epidermal Langerhans cells which are very potent stimulators in antigen presenting assays. Thus, this normal volunteer study provides an important source of fresh epidermal tissue from which we can study normal epidermal Langerhans cell function. In addition, we have recently used blister roofs in important experimental models of HIV-1 transmission. There is no other method available for assessing the biologic function of freshly isolated Langerhans cells without altering their milieu. It is a very safe and effective way to obtain human epidermal samples.
There are both theoretical accounts and empirical evidence for the fact that, in health communication, narratives (story telling) may have a persuasive advantage when compared with information (the provision of facts). The dominant explanation for this potential advantage is that narratives inhibit people's resistance to persuasion, particularly in the form of counterarguing. Evidence in this area to date has most often been gathered through lab or field experiments. In the current study we took a novel approach, gathering our data from naturally-occurring, non-experimental and organically evolving online interactions about vaccinations. We focus on five threads from the parenting forum Mumsnet Talk that centered on indecision about the HPV vaccination. Our analysis revealed that narratives and information were used by posters in similar quantities as a means of providing vaccination-related advice. We also found similar frequencies of direct engagement with both narratives and information. However, our findings showed that narratives resulted in a significantly higher proportion of posts exhibiting supportive engagement, whereas information resulted in posts exhibiting a significantly higher proportion of challenges, including counterarguing and other manifestations of posters' resistance to persuasion. The proportions of supportive versus challenging engagement also varied depending on the topic and vaccine stance of narratives. Notwithstanding contextual explanations for these patterns, our findings, based on this original approach of using naturalistic data, provide a novel kind of evidence for the potential of narratives to inhibit counterarguing in authentic health-related discourse.
The primary assessment of PK similarity will be based upon a 90 percentage confidence interval (CI) for the ratio of the geometric means (TRS003, China-approved bevacizumab and US-licensed Avastin®) for AUC0-inf on PK analysis set. If the 90 percentage CI of the ratio of the geometric means for AUC0-inf is within the range of 80-125 percentage, then PK similarity will be concluded. Secondary PK parameters such as but not limited to Cmax, AUClast will be analyzed using the same statistical approach. A nonparametric approach, for example, Wilcoxon signed-rank test, will be taken to evaluate parameters such as t1/2. Exploratory analyses may be performed for other PK parameters as deemed appropriate. All adverse events (AEs) will be listed and summarized using descriptive methodology. The incidence of AEs for each treatment will be presented by severity and association with the study drugs. Clinical laboratory parameters, vital signs, and electrocardiogram (ECG) parameters will be listed and summarized using descriptive statistics. The number and percentage of participants testing positive for anti-drug antibodies (ADAs) will be summarized by treatment and time point.
INTRODUCTION: With it becoming a global pandemic, the coronavirus disease of 2019 (COVID-19) imposed public health restraints that hampered patient's presentation to hospitals. In Lebanon, little is known about the presentation patterns of acute appendicitis (AA) patients among different population groups during the COVID-19. Therefore, this study aims to assess the effects of the COVID-19 pandemic on the rates of cases seen during the pandemic period, the adopted management strategies, and evaluate the patient outcomes compared to presentations from previous years.
METHODS: This is a retrospective, observational cohort study with no interventional procedures. All patients presented to our tertiary health care center were diagnosed with AA between February 2019 and February 2021 comprised the study analysis. We divided our patients into the pre-pandemic period cohort March 1st, 2019, till February 29th, 2020, and the pandemic period cohort March 1st 2020 till March 1st 2021.
RESULTS: We collected data retrospectively from 342 patients: 201 patients presented in the pre-pandemic period and 141 during the pandemic period. Male predominance was seen in both cohorts (51.7% and 58.9% respectively). A decrease in the number of AA cases was seen during the pandemic, however, the duration of symptoms before presentation was similar in both cohorts (p = 0.382) Additionally, the number of complicated appendicitis cases was not different between cohorts. The main imaging modality was CT in both groups with no statistically significant difference in the type of imaging between them (p = 0.398). Further, the predominant treatment modality remained surgery during the pandemic, with no difference between both periods (p = 0.200), and no statistically significant difference in the type of surgery performed as laparoscopic surgery remained the most common surgery type in the pandemic period (p = 0.43). Finally, no extra surgical and post-surgical complications were identified.
CONCLUSION: In conclusion, our study is an example of how the COVID-19 pandemic did not significantly affect patients presenting for AA. Despite the COVID-19-related restrictions, Lebanese patients with worrying symptoms were presenting to the emergency department and the American University of Beirut Medical Center was providing them with the standards of care. Our study mirrors the Lebanese experience and gives an example of a population that focused more on their current symptoms than the fear of acquiring the COVID-19 virus. Further research is needed to assess whether this was the correct approach during these times.
PURPOSE: To prepare a micro-emulsion, particularly a bicontinuous micro- emulsion, by treating an aq. phase and an addition-polymerizable water- immiscible org. material with an addition-polymerizable surfactant. CONSTITUTION: In preparation of a bicontinuous micro-emulsion from an aq. phase, an addition-polymerizable water-immiscible org. material such as styrene and vinyl chloride and a surfactant, an addition-polymerizable surfactant is used as the surfactant. As examples of suitable addition-polymerizable surfactants, cation type ones such as quat. ammonium compounds and tert. amine salts are preferably used. As addition-polymerizable groups in the addition-polymerizable surfactants, (alk)acrylates are preferably used. Further, when the micro-emulsion is treated under polymerizing conditions, a solid compsn. consisting of a continuous solid phase and a continuous aq. liq. phase is obtained, which can be seen as transparent by naked eyes.
BACKGROUND: Acute myocardial infarction (AMI) is a global health problem with high mortality. Early diagnosis can prevent the development of AMI and provide valuable information for subsequent treatment. Angiogenesis has been shown to be a critical factor in the development of infarction and targeting this process may be a potential protective strategy for preventing myocardial injury and improving the prognosis of AMI patients. This study aimed to screen and verify diagnostic markers related to angiogenesis in AMI and to investigate the molecular mechanisms of action associated with AMI in terms of immune cell infiltration.
METHODS: The GSE66360 and the GSE60993 datasets were both downloaded from the GEO database and were used as the training cohort and the external validation cohort, respectively. Angiogenesis-related genes (ARGs) were downloaded from the MSigDB database. The hub ARGs were identified via LASSO, RF, and SVM-RFE algorithms. ROC curves were used to assess the accuracy of the hub ARGs. The potential mechanisms of the hub ARGs were analyzed by GSEA. The ssGSEA algorithm was used to determine differences in immune cell infiltration and immune function. The CIBERSORT algorithm was used for immune cell infiltration analysis. In addition, we constructed a ceRNA network map of differentially expressed ARGs.
RESULTS: We identified the thrombomodulin (THBD) gene from ARGs as a potential diagnostic marker for AMI based on the LASSO, SVM-RFE, and RF algorithms. THBD was differentially expressed and had a potential diagnostic value (area under the curve [AUC] = 0.931 and 0.765 in the training and testing datasets, respectively). GSEA showed that the MAPK signaling pathway was more enriched in the high-expression group of THBD (P < 0.05). Immune cell infiltration analysis demonstrated that THBD was mainly positively correlated with monocytes (R = 0.48, P = 0.00055) and neutrophils (R = 0.36, P = 0.013). Finally, in the ceRNA regulatory network, THBD was closely associated with 9 miRNAs and 42 lncRNAs involved in AMI.
CONCLUSION: THBD can be used as a potential diagnostic marker for AMI. This study provides new insights for future AMI diagnosis and molecular mechanism research. Moreover, immune cell infiltration plays an essential role in the occurrence and development of AMI.
Contradictory reports regarding the effects of nanoselenium (NanoSe) on the performance of broiler chickens may occur. Therefore, the optimum supplementation of NanoSe doses needs to be determined. The current meta-analysis study was aimed at evaluating the effectiveness and the optimum doses of NanoSe supplementation in broiler diets on performance, blood constituents, carcass, and giblet weight by considering breed and sex. The database was obtained from online scientific publications by searching through search engines such as Scopus, Web of Science, Google Scholar, and PubMed by entering the keywords nanoselenium, performance, antioxidants, and broiler. A total of 25 articles were included in the meta-analysis database. The study group was treated as a random effect while NanoSe dose, breed, and sex were treated as fixed effects. Daily body weight gain, carcass weight, and breast weight increased quadratically (P < 0.05), and FCR decreased quadratically (P < 0.05) in the starter and cumulative periods with increasing NanoSe supplementation. NanoSe supplementation tended to decrease cumulative feed intake linearly (P < 0.1) and decreased (P < 0.05) abdominal fat, albumin, red blood cells, ALT, and MDA levels. In contrast, levels of total protein, globulin, glucose, AST, white blood cells, cholesterol, triglyceride, and the weight of the liver, heart, gizzard, bursa of Fabricius, thymus, and spleen were not affected by NanoSe supplementation. Increasing the dose of NanoSe increased (P < 0.05) the GSHPx enzyme and Se concentration in breast muscle and liver and tended to enhance (P < 0.01) the CAT enzyme. It is concluded that a proper dose of NanoSe supplementation in a broiler diet improves body weight gain, feed efficiency, carcass, and breast weight without adverse effects on giblets. Dietary NanoSe elevates Se concentration in the breast muscle and liver and antioxidant activity. The current meta-analysis shows that the optimum dose for body weight gain and FCR is 1 to 1.5 mg/kg.
PROBLEM TO BE SOLVED: To obtain a dental filling composition good in transparent feeling by blending a composite ponder in which an inorganic oxide is uniformly dispersed in a vinyl polymer, with a system consisting of a polymerizable monomer with a polymerization initiator and also specifying its refractive index. SOLUTION: This dental filling composition is obtained by blending 40-400 pts.wt. powder of a composite in which the first inorganic oxide is uniformly dispersed in a vinyl polymer matrix with 100 pts.wt. polymerizable monomer and 0.01-10 pts.wt. polymerization initiator. Also, the difference in refractive indices between the polymer of the above monomer and the powder of the composite is made as <=0.1. As the composite, it is preferable that the content of the first inorganic oxide is <=20% and a light transparency in 400-800nm range measured by using a plate of 1.5mm plate thickness, is >=70%. The mean particle diameter of the composite powder is preferably 1-100μm. As the inorganic oxide, the fine particles of a silica is preferable in view of its cost and the ease of its availability.  The composition is transparent and excellent in working property of its paste, gloss of its cured resin surface, mechanical strength and wear resistance.
The present invention relates to complex calcium which is a novel calcium product. Ionic calcium and amino acid are compounded under the action of enzyme, which forms a soluble calcium product of the present invention. The present invention uses fresh bones of animals as raw material. The action of the enzyme leads calcium in bone material to become into molecule type bone material, ion type bone material and complex type bone material. Compared with a molecule calcium product and an ion calcium product, the present invention is easily and thoroughly absorbed by a human body and is effectively utilized. A preparation method comprises the following steps: the bone material becomes into a mixture of molecule calcium under the action of alkaline enzyme; the mixture of molecule calcium is converted into soluble ionized calcium under the action of dilute acid; the ionized calcium and amino acid which is necessary for a human body are compounded under the action of acid proteinase to form a calcium complex compound. The complex calcium of the present invention can be used as a calcium complement preparation, calcium food or a food additive.
Swallowing impairments (dysphagia) represent the highest functional morbidity in veteran patients treated for oropharyngeal cancers with either surgical approaches followed by radiation or with more recent organ-preservation protocols. The nature of the impairments is often resistive to treatment and results in life-long health consequences and high cost burden on the VA health system. Recent preliminary data have linked alterations in the otherwise highly stable respiratory-swallowing phase pattern relationships to the swallowing impairment and penetration/aspiration and in this patient group. The immediate goal of this clinical trial is to test the effect of a novel respiratory-swallow intervention on swallowing impairment and penetration/aspiration in a cohort of chronically dysphagic veterans following treatment for oropharyngeal cancer. Patients presenting with a "non-optimal" respiratory-swallow phase pattern during liquid swallows and measurable swallowing impairment will learn an "optimal" physiologic pattern that facilitates both airway protective and mechanical advantages during swallowing. The broad goal of this research is to develop ideal respiratory-swallowing phase training methods and regimens that alone or combined with traditional swallowing treatments improve swallowing function in the acute phases of recovery and improve long term patient outcome. Our intention is to use these preliminary data to motivate a larger clinical trial to compare the effect of respiratory-swallow phase training with other evidenced based methods of swallowing treatment and expand the approach to other patient groups that have indications of respiratory-swallow phase impairments (e.g. pulmonary disease and stroke) contributing to impaired swallowing function
Patients with Hyperaldosteronism will either be treated by adrenalectomy (adrenal adenoma) or receive medical treatment (Spironolactone/Eplerenone; bilateral hyperplasia) as indicated by the Endocrinological Guideline (J Clin Endocrinology \& Metabolism, May 2016). Before and after intervention tissue sodium and tissue potassium amount will be assessed by MRI.
The present invention relates to a moxibustion pocket comprising: a moxibustion pocket which is made of cotton cloth and can be produced in several colors according to the prescribed therapy for each body part; an inside vinyl for protecting moxibustion materials by blocking air to not permeate inside the moxibustion pocket; a string for tying a knot in the moxibustion pocket; and moxibustion pocket materials mixed with native grasses which are not chemically treated but are treated with bay salt so that cool moxibustion or warm moxibustion is performed together with pressuring and aromatherapy on each of the chakra parts and body parts by chakra color therapy prescribed according to the colors and positions of the chakra parts and body parts. The moxibustion pocket is used to perform cool moxibustion or warm moxibustion by using moxibustion pocket materials contained in the vinyl inside the moxibustion pocket made of cotton cloth along with chakra color therapy prescribed according to the positions of the seven chakra parts and the body parts. The moxibustion pocket is effective in improving blood circulation and alleviating menopausal disorder, a feeling of coldness in the hands and feet, and insomnia. For cool moxibustion, the moxibustion pocket is used after being kept in a freezer; for warm moxibustion, the moxibustion pocket is used after being heated in a microwave for one minute or less. When not used for moxibustion, the moxibustion pocket can be put beside a user at bedtime for aromatherapy. After it is torn, the moxibustion pocket can be used for a foot bath or used as perfume.