anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Troponin (Tn) is a biomarker related to myocardial necrosis and is elevated in patients with myocarditis. This study aimed to investigate the association between cardiac Tn levels and the course of cardiac function, and prognosis in patients with fulminant myocarditis (FM) receiving percutaneous mechanical circulatory support (MCS).We used data from a multicenter retrospective registry, CHANGE PUMP 2, which included 216 patients with FM who required MCS. Among them, 141 patients whose Tn levels were available were analyzed. The patients were divided into low and high Tn groups according to the median values of TnT and TnI.The median age was 54 years, and 59.6% were male. The TnT and TnI on day 1 (at MCS initiation) were 3.8 (1.4-10.0) and 21.4 (8.4-68.8) ng/mL. While the left ventricular ejection fraction (LVEF) was similar on day 1 (25.0% versus 24.5%), the low Tn group showed better LVEF improvement on day 7 than the high Tn group (45.0% versus 25.3%, P < 0.001). LVEF at 1 year after admission was higher in the low Tn group (65.0% versus 59.7%, P = 0.039). The low Tn group had a better 90-day composite endpoint in death, durable left ventricular assist device implantation, and heart transplantation compared to the high Tn group (hazard ratio 0.47, 95% CI 0.23-0.95).Tn levels were associated with short- and long-term cardiac recovery and adverse outcomes in patients with FM receiving MCS due to cardiogenic shock.
Cucumber blight is a destructive disease. The best way to control this disease is resistance breeding. This study focuses on disease resistance gene mapping and molecular marker development. We used the resistant cucumber, JSH, and susceptible cucumber, B80, as parents to construct F2 populations. Bulked segregant analysis (BSA) combined with specific length amplified fragment sequencing (SLAF-seq) were used, from which we developed cleaved amplified polymorphic sequence (CAPs) markers to map the resistance gene. Resistance in F2 individuals showed a segregation ratio of resistance:susceptibility close to 3:1. The gene in JSH resistant cucumber was mapped to an interval of 9.25 kb, and sequencing results for the three genes in the mapped region revealed three mutations at base sites 225, 302, and 591 in the coding region of Csa5G139130 between JSH and B80, but no mutations in coding regions of Csa5G139140 and Csa5G139150. The mutations caused changes in amino acids 75 and 101 of the protein encoded by Csa5G139130, suggesting that Csa5G139130 is the most likely resistance candidate gene. We developed a molecular marker, CAPs-4, as a closely linked marker for the cucumber blight resistance gene. This is the first report on mapping of a cucumber blight resistance gene and will provideg a useful marker for molecular breeding of cucumber resistance to Phytophthora blight.
An implantable osmotic pump system includes a rigid pump housing defining an opening adapted to receive a catheter; one or more membrane assemblies fitted to the pump housing; an osmotic engine within the rigid pump housing and a flexible pharmaceutical agent compartment disposed within the pump housing. The flexible pharmaceutical agent compartment is adapted to enclose a volume of a pharmaceutical agent and to cause the pharmaceutical agent to be infused through the opening as water crosses the membrane assembly or assemblies and increases the volume of the osmotic engine. The flexible pharmaceutical agent compartment may include polyethylene teraphthalate (PET), for example, and/or may include a metallic layer such as gold, silver, platinum and/or aluminum, for example, to inhibit the transfer of gas or liquid across the compartment. A catheter may be bonded to the opening of the pump housing and to a corresponding opening in the flexible pharmaceutical agent compartment. The flexible pharmaceutical agent compartment may be free floating inside the pump housing, being only attached to the catheter and/or to the opening of the pump housing. As the present implantable osmotic pump does not include a movable piston, the pump housing may have a cylindrical shape in which the height of the pump housing is less than the diameter thereof, a non-cylindrical shape and/or a shape that conforms to the patient's anatomy at the implant site.
PCT No. PCT/US96/04721 Sec. 371 Date Nov. 12, 1996 Sec. 102(e) Date Nov. 12, 1996 PCT Filed Apr. 5, 1996 PCT Pub. No. WO96/31226 PCT Pub. Date Oct. 10, 1996Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip formts an angle of about 180 DEG /N with the longitudinal axes of at least two other strips of submucosal tissue.
This was a randomised, controlled, clinical trial on patients who received a primary knee prosthesis in 2018-2019. Treatment group was given a multi-layer foam dressing with Safetac. The control group received standard treatment with povidone-iodine and a gauze dressing with plaster. 50 patients was needed for sufficient power. Primary outcome measures were; the characteristics of the surgical wound, patient reported comfort and adaptability according to the physiotherapist. Secondary outcome measures were: the clinical status and quality of life level according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Statistical analysis was performed by using IBM SPSS version 25, with a statistical significance of 5%.
Store at controlled room temperature 20°-25°C (68°-77°F). Protect from moisture and excessive heat. Note that contact with moisture may produce surface discolorations of the tablet.

Keep in a well-closed, light-resistant container. Supplied in a child-resistant bottle as a safeguard against ingestion by children. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
Sign languages (SLs) are expressed through different bodily actions, ranging from re-enactment of physical events (constructed action, CA) to sequences of lexical signs with internal structure (plain telling, PT). Despite the prevalence of CA in signed interactions and its significance for SL comprehension, its neural dynamics remain unexplored. We examined the processing of different types of CA (subtle, reduced, and overt) and PT in 35 adult deaf or hearing native signers. The electroencephalographic-based processing of signed sentences with incongruent targets was recorded. Attenuated N300 and early N400 were observed for CA in deaf but not in hearing signers. No differences were found between sentences with CA types in all signers, suggesting a continuum from PT to overt CA. Deaf signers focused more on body movements; hearing signers on faces. We conclude that CA is processed less effortlessly than PT, arguably because of its strong focus on bodily actions.
Generally, the present disclosure provides novel bacterial translocation domains for use in cellular delivery. An example is the translocation domain from the Austwickia chelonae protein of SEQ ID NO:2, the translocation domain having the amino acid sequence of SEQ ID NO: 3. Translocase domains from other bacterial strains and species are also described (e.g. SEQ ID NOs: 4 to 17 and 36 to 48). Recombinant polypeptides comprising these translocation domains are described. The recombinant polypeptides are intended for use in delivery of cargo molecules, including therapeutic polypeptides that may be used to treat disease.
PURPOSE: Right-sided diverticulitis is a rare entity in North Africa. Therefore, it is usually misdiagnosed, and the management of cecal diverticulitis is aggressive in most cases, whereas nowadays, most studies recommend a conservative approach with promising results. This study aims to describe the presentation, management, and outcomes of right-sided diverticulitis (RSD) and to present the experience of one surgical center in Tunisia.
METHODS: This is a retrospective study including all patients presented with RSD, in the Department of Surgery "A" of the Charles Nicolle Hospital between 2007 and 2021.
RESULTS: Forty patients were included in our study. The mean age was 42 years with a standard deviation of 14. The sex ratio was 1.1. Only 2 patients had chronic constipation. All patients presented right-sided abdominal pain, and only 3 patients had diarrhea. Twenty one patients were diagnosed during surgery. Fourteen patients were treated successfully by conservative management. An operative procedure was performed in 26 cases: 21 had a diverticulectomy (80%), two had an ileal resection (8%), and three had a right colectomy (11.5%). No postoperative events occurred with a short hospital stay (5 ± 3 days). Follow-up showed no recurrences.
CONCLUSION: Right-sided diverticulitis has a lower incidence and complication rate compared to left-sided diverticulitis. Conservative treatment has demonstrated favorable outcomes in managing RSD, although the available evidence remains limited.
Women will be instructed in the use of the Ferticare 2.0® vibrator with a frequency of 70 Hz, amplitude of 1.5 mm. It will be recommended to gradually increase its use over time, with a limit of 30 minutes a day.
All participants in the attention control arm received three emails during the 20 month intervention period including (1) NASBE's Fit Healthy and Ready to Learn; A School Health Guide Part II: Policies to Promote Sun Safety and Prevent Skin Cancer, (2) CDC's Guidelines for Sun Safety to Prevent Skin Cancer, and (3) a link to the Surgeon General's 2014 Call to Action to Prevent Skin Cancer. This attention-control treatment will equalize schools on awareness of recommendations to implement school sun safety.
The invention relates to a drug for treating the fatty liver. The drug is prepared from, by weight, 9 parts of semen juglandis, 12 parts of roots of Japanese premna, 10 parts of all-grass of saxifraga stolonifera Meerb., 15 parts of common aeschynomene herb, 6 parts of stems of anderson ironweed, 9 parts of seeds of Japanese snakegourd, 15 parts of dates, 6 parts of large leaf moss and 9 parts of roots of rustyhair raspberries. According to the drug for treating the fatty liver, semen juglandis strengthens the spleen, benefits qi, tonifies the kidney and arrests seminal emission; roots of Japanese premna clear heat and remove toxicity; herba gomphostemma chinense Oliv. induces diuresis and diminishes swelling; common aeschynomene herb clears heat, dispels wind, eliminates dampness, diminishes swelling and removes toxicity; stems of anderson ironweed dispel wind, relieve exterior syndrome, relax muscles and stimulate blood circulation; seeds of Japanese snakegourd clear heat, remove dampness, cool the blood and stop bleeding; dates tonify qi and deficiency, promote digestion, eliminate phlegm and mainly treat qi deficiency and weakness; large leaf moss promotes tranquility, calms nerves, clears away heart-fire and improves eyesight; roots of rustyhair raspberry dispel wind, eliminate dampness and promote blood circulation to remove meridian obstruction. All the medicines are combined for use, and the effects of soothing the liver and strengthening the spleen, dissipating dampness, removing stagnation and eliminating phlegm are achieved. It is proved through clinical tests that the drug can treat the fatty liver safely and effectively.
NEW MATERIAL:A bornane-3-spiro-1'-cyclopentane shown by the formula I (R1 is H and R2 is hydroxy or R1 and R2 are linked to form ketone). EXAMPLE:Bornane-3-spiro-1'-cyclopentan-2-one. USE:Useful as a component for a perfume composition, having particular fragrance based on woody fragrance, excellent as a material to be added to various kinds of perfume. Widely usable as a material requiring frangrance, such as high-quality perfume composition, perfume, soap, shampoo, hair rinse, detergent, cosmetic, spray, aroma agent, etc. PREPARATION:As shown in the reaction formula (X is halogen), camphor is reacted with 1,4-dihalogenobutane in the presence of a base and a proper solvent under heating with stirring to give a compound shown by the formula Ia. Then, this compound is reduced by a method generally used in reduction of a ketone, to give a compound shown by the formula Ib.
PURPOSE:To provide the titled cosmetic composition effective to suppress the separation of amino acids caused by the damage of hair, by compounding a cosmetic with condensed tannin. CONSTITUTION:The objective cosmetic composition contains 0.1-10wt%, preferably 1-5wt%, based on the whole composition, of a condensed tannin (preferably having a molecular weight of 500-3,500) having flavan-3-ol, etc. as a basic structure, e.g. catechin, epicatechin, etc. The condensed tannin can be prepared from various plants and crude drugs; for example, a crude extract containing 20-60wt% of tannin can be obtained by extracting DAIO (rhizome of Rheum palmatum), KASHU (rhizome of Polygonum multiflorum), MAO (stalk of Ephedra sinica), tea, miosa, chestnut, etc. with 30-70% aqueous solution of acetone, >=30% aqueous solution of an alcohol, etc. at room temperature -60 deg.C for 15-60min, repeating the extraction process two - several times, and concentrating and drying the whole extract at <=60 deg.C. The crude extract may be used as it is or after purification.
Several studies have reported that the atherogenic index of plasma (AIP) is associated with serum uric acid (SUA) in healthy middle-aged men, kidney transplant patients, and diabetic patients. We assessed the relationship between AIP and SUA in patients with untreated essential hypertension (EH) in China. In the cross-sectional study, we evaluated 5003 patients with untreated EH in China; 1490 were assigned to the hyperuricemia (HUA) group and 3513 to the normouricemia (non-HUA) group according to the diagnostic criteria of HUA (SUA level≥6 mg/dL in females and ≥7 mg/dL in males). A higher AIP level was found in the HUA group (P < .001), and AIP was positively and independently correlated with SUA after adjusting for statistically significant variables (β = .204, P < .001). Moreover, multivariate logistic regression analysis showed that the AIP was closely and independently related to HUA after adjusting for confounders (odds ratio [OR]: 11.980, 95% confidence interval [CI]: 3.186-45.047, P < .001). Our findings suggested that the AIP was positively and independently associated with SUA, and elevated AIP might be a significant risk factor for HUA in patients with untreated EH in China.
Several studies have reported positive impact of some interventions on the tracheal intubation-related complications incidence. Providing bag face-mask ventilation between medication administration and initiation of laryngoscopy significantly reduced the number of peri intubation hypoxemia episodes. The use of a non-depolarizing (rocuronium) paralytic agent instead of succinylcholine is associated with less post-intubation complications occurrence. Finally, use of a tracheal tube introducer (GEB) as an aid for intubation in emergency patients with at least one prognostic factor of difficult laryngoscopy has been shown to facilitate intubation. Assessment of a strategy combining these three interventions to reduce intubation related morbidity in emergency situations has never been assessed. It is expected that the combination of these interventions will drastically reduce the morbidity associated with emergency intubation. The strategy assessed will associate rocuronium use as paralyzing agent to facilitate intubation, bag mask ventilation before intubation and GEB use at first intubation attempt in all patients. The emergency physician in charge of the patients will record out-of hospital outcomes immediately after the out-of-hospital period. Intra-hospital data will be retrieved from the patient's medical record on the 28th day after inclusion.
UNLABELLED: The association of renal function with fracture incidence during teriparatide or alendronate treatment in elderly Japanese women was examined. Fracture incidence differed by fracture type, renal function, and treatment protocol. The results provide important information on pharmacotherapy in clinical practice for osteoporosis.
PURPOSE: Incidence rate of morphometric vertebral fracture was lower under treatment with once-weekly teriparatide (TPTD) followed by alendronate (ALN) than under treatment with ALN throughout the study among elderly Japanese women at high fracture risk in JOINT-05. This is an exploratory subgroup analysis according to chronic kidney disease (CKD) status at baseline.
METHODS: Participants received sequential therapy with TPTD for 72 weeks, followed by ALN for 48 weeks (TPTD-ALN group, N = 483) or ALN monotherapy for 120 weeks (ALN group, N = 496). Baseline CKD status was classified by the estimated glomerular filtration rate (eGFR) and categorized as: CKD 1/2 (eGFR ≥ 60 mL/min/1.73 m2), CKD 3a (eGFR 45-59 mL/min/1.73 m2), or CKD 3b/4 (eGFR < 45 mL/min/1.73 m2). Incidences of vertebral fractures including morphometric fractures, non-vertebral fractures, and all fractures were evaluated during follow-up.
RESULTS: Baseline characteristics were not different between treatment groups. Higher stages of CKD were associated with age and number of prevalent vertebral fracture. In CKD 1/2 patients (N = 556 with 90 incidents of morphometric vertebral fracture), the incidence of vertebral fractures was lower in the TPTD-ALN group than in the ALN group (p = 0.01). In CKD 3b/4 patients (N = 112 with 10 incidents of non-vertebral fracture), the incidence of non-vertebral fractures was lower in the ALN group than in the TPTD-ALN group, although the number of fractures was small. In the ALN group, the incidences of vertebral fractures, non-vertebral fractures, and all fractures remained constant across CKD stages.
CONCLUSION: This exploratory analysis showed that fracture incidence on ALN was constant regardless of renal function. It also suggested that the incidence of vertebral fractures on TPTD-ALN was lower than ALN monotherapy in CKD 1/2 patients. These results provide important information for drug selection in the clinical practice of osteoporosis.
The invention discloses buxine. It is made up of cyclovirobuxine D, cyclovirobuxine D, and cyclovirobune C. And their weight content respectively is 60%-95%, 1.0%-30%, and 0.5%-20%. It also discloses buxine hydrochloride and its preparation method and their preparation. The formed product has clear composition and structure, effective quality control to ensure stable curative effect and easy to form various modern preparations. Its preparation technology is simple. And its cost is low.
In this stage, the behavior of the variables of functional, clinical and metabolic outcome will be analyzed before the exhaustion protocol and the application of the massage after 1h of passive recovery. Firstly the volunteers will perform the protocol for exercise, followed by a passive recovery of 1h and then the massage application. The functional tests will be performed 2 hours after the stress protocol begins. Again, blood lactate collection and clinical data will occur at specific times.
ERCP will be performed under conscious sedation with intramuscular administration of diazepam 2.5-5.0 mg and pethidine 25-50 mg. If necessary, Endoscopic Sphincterotomy or Endoscopic Papillary Balloon Dilatation will be performed. A dilating bougie or balloon will be used to dilate the stenosis after sphincterotomy. After that, the balloon will be used to remove the stones first, and the basket will replace the balloon after 15 minutes to remove any remaining stones. Finally, the effect of the balloon will be evaluated.
An organic extract (PM-251) from a plant,  Euphorbia hirta  (Euphorbaceae) has been standardized. Agronomical standardization has been achieved on this plant by growing it in eastern North Carolina. Subsequently the PM 251 extract has been chemically and biologically standardized. The standardized extract has been tested for its efficacy as an anti-inflammatory product based on in vitro assays as well as in vivo (animal studies). The standardized extract has significant COX-2 (Cyclooxygenase) enzyme inhibition in vitro. PM-251 has proved to be a good anti-inflammatory agent in sub-acute rat models of inflammation in the doses of 100 mg/kbw, 200 mg/kbw and 400 mg/kbw body weights when given orally.
This study will be a prospective pilot randomized controlled trial. Collaboration will be between the National University Hospital (Medical, Surgical and Cardiothoracic ICUs), Centre for Healthy Aging, National University Health System (NUHS) and Physical Education \& Sports Science, National Institute of Education (NIE). Patients admitted into these ICUs will be screened and those meeting the inclusion criteria will be approached for consent. If the patient is unable to consent, his/her legally acceptable representatives will be approached. This approach is routinely done in ICU studies. As with other ICU studies, potential difficulties in consenting and recruiting patients will be expected. To overcome this, all adult ICU patients at NUH will be included in the current study.
A magnetic medicine paste, comprising a stroma layer, a medicine adhesive layer, a magnetic layer, an anti-sticking layer, wherein the adhesive layer is arranged on top of the stroma layer, the magnets in the magnetic layer are metal grain pills adhered to the medicine adhesive layer, a plurality of uniformly distributed ventilating holes are arranged on the stroma layer and the medicine adhesive layer, the anti-stick layer are adhered to the area of the medicine adhesive layer other than that taken by the metal grains. In the utility model, with the medicine and magnetic grains contacted with the human acupuncture points and lesion tissues directly at the same time, the anti-inflammation and analgesic effect is strong, the curative effect is significant. Further more, no desquamative magnetic powder is formed out of the metal magnetic grains, and the effect is stable. Since the magnetic grains are in the form of grains, when adhered to the acupuncture points, the magnetic grains sometimes have an extra function of pressure massage during sleeping, sitting and walking, which is significant addition to the elimination of the muscle fatigue and rigid discomfort. For through holes are uniformly distributed on the stroma layer and medicine adhesive layer, not only the breathe of the pasted skin is improved, but also the stretching along with the motion of the skin is facilitated, and the pain during tearing off is also reduced. Utilized by multiple people for multiple times, the utility model is felt to be good consistently.
Patients undergoing curative resection for rectal cancer will receive a peritumoural, submucosal administration of indocyanine green and technetium-99m nanocolloid. Intraoperatively the SENSEI gamma probe and Da Vinci Firefly will be used to identify pelvic side wall lymph nodes.