anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
According to Global Burden of Disease data, fractures, which 436 million people suffer from each year, are the second most common musculoskeletal system disorder. Plaster casts have been used in treatment of fractures since 1850, and they play an important role in extremity injuries and the healing of operative repairs. In fractures treated with plaster, the bone alignment is corrected and this alignment is maintained with limited mobility. However, if plaster casts are incorrectly applied or not properly taken care of, this may prevent the healing of fractures and can threaten the safety of patients. Failure to comply with plaster-casting and cast-care principles can cause patients a range of immediate and delayed complications, including severe pain, edema, compartment syndrome, tissue necrosis, malunion, delayed union, nonunion, contracture, neurological problems, paralysis and pressure sores. Orthopedic patients, and especially those with plaster casts, are susceptible to the side effects arising from immobility. They thus need quality care and information to prevent or manage these side effects. Nurses play an important role in prevention or early recognition of complications arising from plaster-casting and in providing the patient with information. Orthopedic nursing requires special skills, knowledge and clinical judgement to provide the plaster cast-patient with safe, quality-care and to prevent complications. Patient education and information are very important for those patients whose treatment continues at home after casting, in order that they can maintain their care and prevent complications.In this study, the sample size was determined with an effect size of 0.43 using the power analysis Gpower 3.1.9.7 program. Accordingly, it was calculated that 29 patients were included in the intervention and control groups with a 5% margin of error and 80% power. İt was decided to include at least 66 people in each working group with 10% surplus, considering that they might be lost in data collection.
The origin of introduction of a new pathogen in a country, the evolutionary dynamics of an epidemic within a country, and the role of cross-border areas on pathogen dynamics remain complex to disentangle and are often poorly understood. For instance, cross-border areas represent the ideal location for the sharing of viral variants between countries, with international air travel, land travel and waterways playing an important role in the cross-border spread of infectious diseases. Unfortunately, monitoring the point of entry and the evolutionary dynamics of viruses in space and time within local populations remain challenging. Here we tested the efficiency of wastewater-based epidemiology and genotyping in monitoring Covid-19 epidemiology and SARS-CoV-2 variant dynamics in French Guiana, a tropical country located in South America. Our results suggest that wastewater-based epidemiology and genotyping are powerful tools to monitor variant introduction and disease evolution within a tropical country but the inclusion of both clinical and wastewater samples could still improve our understanding of genetic diversity co-circulating. Wastewater sequencing also revealed the cryptic transmission of SARS-CoV-2 variants within the country. Interestingly, we found some amino acid changes specific to the variants co-circulating in French Guiana, suggesting a local evolution of the SARS-CoV-2 variants after their introduction. More importantly, our results showed that the proximity to bordering countries was not the origin of the emergence of the French Guianese B.1.160.25 variant, but rather that this variant emerged from an ancestor B.1.160 variant introduced by European air plane travelers, suggesting thus that air travel remains a significant risk for cross-border spread of infectious diseases. Overall, we suggest that wastewater-based epidemiology and genotyping provides a cost effective and non-invasive approach for pathogen monitoring and an early-warning tool for disease emergence and spread within a tropical country.
The recommended dosage of cabergoline tablets for initiation of therapy is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient's serum prolactin level. Before initiating treatment, cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.

Dosage increases should not occur more rapidly than every 4 weeks, so that the physician can assess the patient's response to each dosage level. If the patient does not respond adequately, and no additional benefit is observed with higher doses, the lowest dose that achieved maximal response should be used and other therapeutic approaches considered. Patients receiving long term treatment with cabergoline should undergo periodic assessment of their cardiac status and echocardiography should be considered.

After a normal serum prolactin level has been maintained for 6 months, cabergoline may be discontinued, with periodic monitoring of the serum prolactin level to determine whether or when treatment with cabergoline should be reinstituted. The durability of efficacy beyond 24 months of therapy with cabergoline has not been established.
Two electrodes will be applied to the scalp (one on the left motor cortex, one on the right supraorbital cortex). Sham stimulation with 2mA for 40 seconds will be applied.
Septic shock is a devastating illness and the most severe form of infection seen in the intensive care unit (ICU). It is characterized by cardiovascular collapse, failure of organs and is common with severe repercussions including a mortality of 20-40%. Survivors suffer long-term impairment in function and reduced quality of life (QOL). Despite decades of research examining different immune therapies, none has proven successful and supportive care remains the mainstay of therapy, at a cost of approximately 4-billion dollars in Canada annually. MSCs represent a potentially novel treatment for sepsis because in animal models, MSCs have been shown to modulate the immune system, increase pathogen clearance, restore organ function, and reduce death.

The Phase II multi-centre double blind Umbilical Cord Cellular Immunotherapy for Septic Shock RCT (UC-CISS II) will examine intermediate measures of clinical efficacy (primary outcome) as well as biomarkers, safety, clinical outcome measures, and a health economic analysis (secondary outcomes). To answer these aims, UC-CISS II will randomize 296 patients who are admitted to the ICU with septic shock to 300 million cryopreserved, allogeneic, umbilical cord-derived MSCs or placebo across several Canadian academic centres over approximately 2.5 years.
The present invention relates to a Chinese medicine preparation which has the effect of invigorating stomach, promoting digestion, keeping fit and benefiting qi. The invention is characterized in that the Chinese medicine preparation is prepared by the following crude drugs as raw materials by weight: 20-80 parts of ginseng, 70-130 parts of bighead atractylodes rhizome (bran stir-fried), 70-130 parts of picrorhiza rhizome, 1-60 parts of liquorice, 50-110 parts of quisqualis fruit (decladded), 40-100 parts of whitethorn, 40-100 parts of medicated leaven (stir-fried), 1-50 parts of coptis, 40-100 parts of wheat germ (stir-fried), 30-90 parts of poria cocos wolf and 20-80 parts of Chinese aloe. The ginseng, bighead atractylodes rhizome, picrorhiza rhizome, Chinese aloe and coptis are crushed to fine powder and are sieved for standby. The medicated leaven is percolated with 25146005230f ethanol, and then the ethanol is recycled. The quisqualis fruit and liquorice beverage are boiled twice. The boiled water liquid is combined and filtered. The whitethorn, the wheat germ and poria cocos wolf are immersed twice in moderate temperature. The moderate temperature immersion liquids are combined and filtered. The percolated liquid, the boiled liquid and moderate temperature immersion liquid are mixed and condensed to paste. The condensed paste is added with powders of ginseng, etc. and supplementary material and is mixed to uniform. Various common oral preparation can be prepared. The Chinese medicine preparation provided by the invention has the advantages of remarkable curative effect, stomach invigorating, digestion promoting, fit keeping and qi benefiting. The Chinese medicine preparation is used for treating indigestion of child, food and milking taking stoppage and weak somatoplasm.
Extended Pharmacogenomic prescribing for a period of 12 months. Participants will receive pharmacogenomic testing across a range of clinically relevant variants, to guide the dose and drug selection of 27 drugs commonly used in supportive care. The participants will be followed up for a minimum of 12 weeks, with maximal time-period being 12 months depending on time of enrolment.
Food-related functional substances with biological activity serve as a crucial material foundation for achieving precision nutrition, which has gained increasing attraction in regulating physiological functions, preventing chronic diseases, and maintaining human health. Nutritional substances typically include bioactive proteins, peptides, polysaccharides, polyphenols, functional lipids, carotenoids, probiotics, vitamins, saponins, and terpenes. These functional substances play an essential role in precise nutrition. This chapter introduces and summarizes typical functional substances to demonstrate the challenges in precision nutrition for their stability, solubility, and bioavailability. The current status of delivery systems of functional substances is described to give an insight into the development of desirable characteristics, such as food grade status, high loading capacity, site targeting, and controlled release capacity. Finally, the applications of food-borne delivery systems of functional substances for precision nutrition are emphasized to meet the requirement for precision nutrition during nutritional intervention for chronic diseases.
The present invention concerns methods and compositions for forming complexes of interferon-? with an antibody or antigen-binding antibody fragment. In preferred embodiments, the interferon-? and the antibody or fragment are fusion proteins, each comprising a dimerization and docking domain (DDD) moiety from human protein kinase A or an anchor domain (AD) moiety from an A-kinase anchoring protein (AKAP). In more preferred embodiments, the interferon-antibody complex is more efficacious for treatment of cancer, asthma, Alzheimer's disease, multiple sclerosis or viral infection than interferon-? alone, antibody alone, or the combination of unconjugated interferon-? and antibody.
FIELD: medicine. SUBSTANCE: the method deals with evaluating the concentration of blood serum testosterone in mature male mice 72 h after a single injection of a test dose of the preparation equal to 25 mcg/ml total peptides at the volume of 0.5 ml/mouse in case of parallel injecting for a control group a sterile isotonic solution of sodium chloride at the same volume. The preparation is considered to be biologically active if it provides the increase of testosterone concentration by not less than 4 times against a control group. Concentration of serum testosterone could be determined by any of the well-known methods, for example, by immune-enzymatic assay with application of commercial test systems. The method enables to quantitatively detect biological activity of different medicinal forms of preparations made of prostatic tissue. EFFECT: higher accuracy of results. 1 cl, 1 tbl
Salsalate 2grams twice a day for 30 days. Then Placebo for 30 days.
Electrospun Polyvinyl Alcohol (PVA)/Inulin composite nanofibers (CNFs) are provided using electrospinning technique and tested for their prebiotic and antibacterial activities. The PVA/Inulin electrospun CNFs were tested for prebiotic activity with  Lactobacillus  sp. and for antibacterial activity against both  Escherichia coli  ( E. coli ) and  Staphylococcus aureus  ( S. aureus ). A number of electrospinning parameters such as solution concentration, PVA: Inulin mixing ratio, solution flow rate and applied voltage were carefully varied and the best PVA/Inulin electrospun CNFs (bead free) were selected for prebiotic and antibacterial tests. The concentration of the composite solution varied between 14-20%, the flow rate ranged between 0.005-0.5 mL/min and the applied voltage used ranged between 15-20 Kv. The structural properties and morphology of the PVA/Inulin electrospun CNFs were fully characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and scanning electron microscopy (SEM).
The experimental condition includes an online psychological intervention with therapist email guidance based on Acceptance \& Commitment Therapy (ACT). ACT is a form of Cognitive Behavioral Therapy, which focuses on acceptance of chronic pain in order to be able to perform valuable activities, instead of attempts of avoidance and controlling (Hayes et al., 2012). The main goal of ACT is increasing psychological flexibility, which includes the ability to act effectively according to personal values, with pain. ACT can thereby play a role in creating more realistic expectations regarding expectations of future pain relief. The intervention can be worked through in the participant's own living environment. It consists of 6 modules which can be worked through in 8 weeks.
Hyponatremia may occur as a result of treatment with SSRIs and SNRIs, including Venlafaxine Extended-Release Tablets. In many cases, this hyponatremia appears to be the result of the Syndrome of Inappropriate antidiuretic hormone secretion (SIADH). Cases with serum sodium lower than 110 mmol/L have been reported. Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs. Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk [see Use in Specific Populations (8.5)]. Discontinuation of Venlafaxine Extended-Release Tablets should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted.

Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls. Signs and symptoms associated with more severe and/or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death.
PROBLEM TO BE SOLVED: To select a suitable container efficiently without a complicated aging test by selecting a container taking the squeeze strength of a plastic container as an index in filling the plastic container with a cosmetic in which a polyether modified silicone is mixed. SOLUTION: In filling a plastic container with a cosmetic in which polyether modified silicone is mixed, a container is selected taking the squeeze strength of the plastic container as an index. In this case, it is preferable that the plastic container with the squeeze strength of 3.0 kg is selected. As a concrete example of resin for the plastic container, high density polyethylene or the like is cited. The squeeze strength shows the resisting force when the wall surface central part most easy to be squeezed of an empty plastic container is pressed by 5 mm vertically inward at room temperature of 21 deg.C, with a diameter of 15 mm of a compressing part, and at a pressing rate of 200 mm/min. by using a push-pull gauge of 10 kg as a compression test device.
The present invention provides silica-based fluorescent nanoparticles that can be used to accurately detect, characterize, monitor and treat diseases such as cancer. The diameter of the nanoparticle ranges from about 0.1nm to about 100nm. The nanoparticle has a fluorescent compound located therein and has a higher brightness and fluorescence quantum yield than the free fluorescent compound. The nanoparticles may be coated with an organic polymer, such as polyethylene glycol (PEG). The nanoparticle may further be conjugated with a ligand that is capable of binding to a cellular component associated with a particular cell type. A therapeutic agent may be attached to the nanoparticle. In order to make the nanoparticle detectable not only by optical fluorescence imaging but also by other imaging techniques, a radionuclide/radiometal or paramagnetic ion may be conjugated to the nanoparticle.
The invention discloses a composition obtained by fermenting tetrastigma hemsleyanum diels et gilg. through edible and medicinal fungi and a preparation method of the composition. The composition comprises a tetrastigma hemsleyanum diels et gilg. fermentation subcritical extract I and a streptomycete fermentation product III, and has a favorable function of reducing blood lipid. The preparation method comprises the following steps of inoculating Brazilian mushroom liquid seed fluid into tetrastigma hemsleyanum diels et gilg. solid state fermentation culture mediums for culturing, wherein the tetrastigma hemsleyanum diels et gilg. solid state fermentation culture mediums contain tetrastigma hemsleyanum diels et gilg. and bletilla striata, and then placing the cultured Brazilian mushroom liquid seed fluid in alternating magnetic field environment for culturing once again so as to obtain tetrastigma hemsleyanum diels et gilg. solid state fermentation products; then performing subcritical water extraction so as to obtain the tetrastigma hemsleyanum diels et gilg. fermentation subcritical extract I; inoculating streptomycete seed fluid into streptomycete liquid fermentation culture mediums for culturing so as to obtain the streptomycete fermentation products III, wherein the streptomycete liquid fermentation culture mediums contain extraction remnants II. According to the method disclosed by the invention, nutrient components and effective components in the tetrastigma hemsleyanum diels et gilg. can be effectively biodegraded and utilized, and the increase of the content and the activity of active components in finished products is facilitated.
Escherichia coli F18 (E. coli F18) is the main cause of bacterial diarrhea in piglets. Previous transcriptome reported that ST3GAL1 was associated to E. coli F18 infection. However, its role in mediating the resistance to E. coli F18 remains elusive. Here, we revealed that the downregulation of ST3GAL1 expression contributed to the enhancement of E. coli F18 resistance in IPEC-J2 cells. Bisulfite sequencing identified 26 methylated CpG sites in the ST3GAL1 core promoter. Among these, the ST3GAL1 mRNA levels significantly correlated with methylation levels of the mC-8 site in the specificity protein 1 (SP1) transcription factor (P < 0.01). Interestingly, ST3GAL1 expression may enhances the immune response by activating TLRs signaling, meanwhile decreases the production of the E. coli F18 receptor by inhibiting glycosphingolipid biosynthesis signaling, thereby leading to enhance the resistance to E. coli F18 infection. Besides, low ST3GAL1 expression may increase E. coli resistance by reducing sialylation. Together, these results support the status of ST3GAL1 as a viable target for efforts to modulate E. coli F18 susceptibility, offering a theoretical foundation for the use of this gene as a key biomarker for molecular breeding to improve porcine disease resistance.
Ovarian tumor domain-containing protease 1 (OTUD1) is a critical negative regulator that promotes innate immune homeostasis and is extensively involved in the pathogenesis of sepsis. In this study, we performed a powerful integration of multiomics analysis and an experimental mechanistic investigation to elucidate the immunoregulatory role of OTUD1 in sepsis at the clinical, animal and cellular levels. Our study revealed the upregulation of OTUD1 expression and the related distinctive alterations observed via multiomics profiling in clinical and experimental sepsis. Importantly, in vivo and in vitro, OTUD1 was shown to negatively regulate inflammatory responses and play a protective role in sepsis-induced pathological lung injury by mechanistically inhibiting the activation of the transforming growth factor-beta-activated kinase 1 (TAK1)-mediated mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways in the present study. Subsequently, we probed the molecular mechanisms underlying OTUD1's regulation of NF-κB and MAPK pathways by pinpointing the target proteins that OTUD1 can deubiquitinate. Drawing upon prior research conducted in our laboratory, it has been demonstrated that tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) performs a protective function in septic lung injury and septic encephalopathy by suppressing the NF-κB and MAPK pathways. Hence, we hypothesized that TIPE2 might be a target protein of OTUD1. Additional experiments, including Co-IP, immunofluorescence co-localization, and Western blotting, revealed that OTUD1 indeed has the ability to deubiquitinate TIPE2. In summary, OTUD1 holds potential as an immunoregulatory and inflammatory checkpoint agent, and could serve as a promising therapeutic target for sepsis-induced lung injury.