anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Spontaneous spinal epidural hematoma (SSEH) is a rare pathology characterized by a hemorrhage in the spinal epidural space without prior surgical or interventional procedure. Recent literature reported contradictory findings regarding the clinical, radiological and surgical factors determining the outcome, hence the objective of this retrospective analysis was to re-assess these outcome-determining factors.
METHODS: Patients surgically treated for SSEH at our institution from 2010 - 2022 were screened and retrospectively assessed regarding management including the time-to-treatment, the pre-and post-treatment clinical status, the radiological findings as well as other patient-specific parameters. The outcome was assessed using the modified McCormick Scale. Statistical analyses included binary logistic regression and Fisher's exact test.
RESULTS: In total, 26 patients (17 men [65%], 9 women [35%], median age 70 years [interquartile range 26.5]) were included for analysis. The SSEHs were located cervically in 31%, cervicothoracically in 42% and thoracically in 27%. Twenty-four patients (92%) improved after surgery. Fifteen patients (58%) had a postoperative modified McCormick Scale grade of I (no residual symptoms) and 8 patients (31%) had a grade of II (mild symptoms). Only 3 (12%) patients remained with a modified McCormick Scale grade of IV or V (severe motor deficits / paraplegic). Neither time-to-treatment, craniocaudal hematoma expansion, axial hematoma occupation of the spinal canal, anticoagulation or antiplatelet drugs, nor the preoperative clinical status were significantly associated with the patients' outcomes.
CONCLUSION: Early surgical evacuation of SSEH generally leads to favorable clinical outcomes. Surgical hematoma evacuation should be indicated in all patients with symptomatic SSEH.
The clot collected from the blood samples is pressed through a calibrated compression system into the PRF box the folded membrane is measured and adjusted to 1,5 mm, then transferred on a sterile gauze. A modified coronally advanced flap technique (MCAF) is used to treat the recession defect, the PRFs are placed over the exposed root surface, ﬂap is coronally positioned and sutures over the enamel in a tension-free position.
AIMS: The aims of this study were to determine the success of a reconstruction algorithm used in major acetabular bone loss, and to further define the indications for custom-made implants in major acetabular bone loss.
METHODS: We reviewed a consecutive series of Paprosky type III acetabular defects treated according to a reconstruction algorithm. IIIA defects were planned to use a superior augment and hemispherical acetabular component. IIIB defects were planned to receive either a hemispherical acetabular component plus augments, a cup-cage reconstruction, or a custom-made implant. We used national digital health records and registry reports to identify any reoperation or re-revision procedure and Oxford Hip Score (OHS) for patient-reported outcomes. Implant survival was determined via Kaplan-Meier analysis.
RESULTS: A total of 105 procedures were carried out in 100 patients (five bilateral) with a mean age of 73 years (42 to 94). In the IIIA defects treated, 72.0% (36 of 50) required a porous metal augment; the remaining 14 patients were treated with a hemispherical acetabular component alone. In the IIIB defects, 63.6% (35 of 55) underwent reconstruction as planned with 20 patients who actually required a hemispherical acetabular component alone. At mean follow-up of 7.6 years, survival was 94.3% (95% confidence interval 97.4 to 88.1) for all-cause revision and the overall dislocation rate was 3.8% (4 of 105). There was no difference observed in survival between type IIIA and type IIIB defects and whether a hemispherical implant alone was used for the reconstruction or not. The mean gain in OHS was 16 points. Custom-made implants were only used in six cases, in patients with either a mega-defect in which the anteroposterior diameter > 80 mm, complex pelvic discontinuity, and massive bone loss in a small pelvis.
CONCLUSION: Our findings suggest that a reconstruction algorithm can provide a successful approach to reconstruction in major acetabular bone loss. The use of custom implants has been defined in this series and accounts for < 5% of cases.
PURPOSE:To obtain a prophylactic agent effective in preventing infectious diseases caused by pathogens and viruses, by using a sialic acid-bonded protein, etc., as active component. CONSTITUTION:The objective prophylactic agent contains a sialic acid-bonded protein originated from cow's milk (e.g. k-casein or lactoferrin) or a sialic acid-bonded peptide produced by the protease-treatment of said sialic acid- bonded protein (e.g. glycomacropeptide originated from k-casein) as an active component. k-Casein contains >=2g/100g of sialic acid and >=5g/100g of glycomacropeptide (GMP) and has an effect to prevent the adhesion of E.coli to a cell, HI activity against viruses and an effect to inhibit the transformation of lymphocyte by EVB. It exhibits remarkable effect to prevent diarrhea caused by infection, group prophylaxis against the prevalence of influenza or canceration of lymphotcyte by EVB, etc.
The present invention relates to emulsions comprising an emulsification system comprising a mixture of at least one cationic surfactant, at least one anionic surfactant, at least one “bridging surfactant”, an oil and water, along with methods for preparing such emulsions. More specifically, the invention relates to stable, synergistic emulsions of various oils, water, cationic, anionic, and bridging surfactants that are useful in preparing a variety of finished personal care, laundry, and cleaning products, including for examples creams, lotions, sunscreens, liquid dish detergents, laundry detergents, automatic dishwasher detergents, hand soaps, laundry bars, personal cleansing bars, multi-purpose cleaners, multi-functional shampoos, body washes, and textile treatment compositions. The emulsifications of the present invention also may be employed in agricultural and pesticide applications. Additionally, the surfactant blends may be utilized in antimicrobial formulations (e.g., antimicrobial hard surface cleaners, hand soaps, shampoos, and dish detergents), soft-terg delivery systems and pre-spotter compositions. The emulsification system of the instant invention, even when utilized in low levels, is capable allowing for the emulsification of very high levels of oils in water, whereby such emulsions are storage stable over extended periods of time at various temperatures. Additionally, concentrated emulsions of the invention are readily dilutable to very low concentrations of, and yet, are also extremely stable phase systems. The instant invention further provides sunscreen emulsions, solid particulate matter suspensions and methods of producing the same.
BACKGROUND: Ankylosing spondylitis (AS) is an autoimmune disease that affects millions of individuals. Immune cells have been recognized as having a crucial role in the pathogenesis of AS. However, their relationship has not been fully explored.
METHODS: We chose to employ Mendelian randomization (MR) to investigate the potential correlation between immune cells and AS. We sourced the data on immune cells from the latest genome-wide association studies (GWASs). We obtained data on AS from the FinnGen consortium. Our comprehensive univariable MR analysis covered 731 immune cells to explore its potential causal relationship with AS. The primary analysis method was inverse-variance weighted (IVW). Additionally, we used Cochran's Q test and the MR-Egger intercept test to assess the presence of pleiotropy and heterogeneity. We examined whether our results could be influenced by individual single-nucleotide polymorphisms (SNPs) using the leave-one-out test. We conducted a bidirectional MR to investigate the reverse relationship. We also applied multivariable MR to decrease the potential influence between the immune cells.
RESULTS: Overall, our univariable MR analysis revealed eight immune cells associated with AS. Among these, four immune cells contributed to an increased risk of AS, while four immune cells were identified as protective factors for AS. However, the Bonferroni test confirmed only one risk factor and one protective factor with a significance level of p < 6.84E-05. CD8 on effector memory CD8+ T cell could increase the risk of AS (p: 1.2302E-05, OR: 2.9871, 95%CI: 1.8289-4.8786). HLA DR on CD33dim HLA DR+ CD11b+ could decrease the risk of AS (p: 1.2301E-06, OR: 0.5446, 95%CI: 0.4260-0.6962). We also identified a bidirectional relationship between CD4 on CD39+ activated CD4 regulatory T cells and AS utilizing the bidirectional MR. To address potential confounding among immune cells, we employed multivariable MR analysis, which revealed that only one immune cell had an independent effect on AS. HLA DR on CD33dim HLA DR+ CD11b+ could decrease the risk of AS (p: 2.113E-06, OR: 0.0.5423, 95%CI: 0.4210-0.6983). Our findings were consistently stable and reliable.
CONCLUSIONS: Our findings indicated a potential link between immune cells and AS, which could provide a new idea for future research. Nevertheless, the specific underlying mechanisms require further exploration.
501,732. Cosmetics. FACTOR & CO., M. June 23, 1937, No. 17498. Convention date, Nov. 27, 1936. [Class 81 (i)] Cosmetics in dry solid cake form are prepared by forming an oil-in-water emulsion of oils, waxes and water-soluble dispersing agent in a large volume of water, adding from 0'76 to 1-25 parts of fillers and pigments to one part of emulsion, drying the mixture and compressing it into cake form. According to an example, 12 parts of a mixture containing 80 per cent olive oil or petroleum oil, 2À25 per cent paraffin wax or beeswax, 13À5 per cent stearic or oleic acid, 1À34 per cent triethanolamine, 0À66 per cent potassium or sodium hydroxide, and 2À24 per cent lauryl or cetyl alcohol is mixed with 8 parts of diethylene glycol, and is emulsified with 60 parts of water and 50 parts of aqueous quince seed extract and the whole is mixed with 0À75 to 1À2 parts of pigments, colours and fillers to each part of emulsion. The proportions of the ingredients may be varied particularly where a cosmetic of reduced masking effect or one to give a shiny effect is required. The cosmetic is applied by means of a wet sponge and is stated to be waterproof in use but to be removable by rubbing with soap and water. In the composition specified above, the oils may be replaced by vegetable or animal oils, benzoinated lard or hydrogenated products ; paraffin wax may be replaced by vegetable or animal waxes ; the dis. persing agents may be replaced by soap, lanoline (Registered Trade Mark), sulphonated alcohols or glycerin ; quince seed extract may be replaced by gum tragacanth, gum karaya, gum acacia, agar, or pectin, and talc may be used as the filler. Reference has been directed by the Comptroller to Specification 474,820.
This study aimed to examine the protective role of nebivolol (NEB) on liver tissue against the lipopolysaccharide (LPS)-induced sepsis model in rats by targeting endoplasmic reticulum (ER) stress-related binding immunoglobulin protein (Bip), CCAAT-enhancer-binding protein homologous protein (Chop) signaling pathways. Four groups, each comprising eight rats, were established: control, LPS, LPS + NEB, and NEB. Biochemical analyses included total oxidant status (TOS), serum aspartate transaminase (AST), and alanine aminotransferase (ALT) levels. Additionally, genetic assessments involved Chop and Bip/GRP78 mRNA expression levels, while histopathological examinations were conducted. Immunohistochemistry was used to determine interleukin-1 beta (IL-1 β) and caspase-3 levels. The LPS group exhibited significantly higher AST, ALT, oxidative stress index, and TOS levels compared to the control group. Moreover, the LPS group demonstrated markedly increased Chop and Bip/GRP78 mRNA expression compared to the control group. Immunohistochemical analysis of the LPS group revealed significant upregulation in IL-1β and caspase-3 expressions compared to the control group. Additionally, the LPS group showed significant hyperemia, mild hemorrhage, and inflammatory cell infiltrations. Comparatively, the LPS+NEB group exhibited a reversal of these alterations when compared to the LPS group. Collectively, our findings, suggest that NEB holds promise as a treatment in conditions where oxidative damage, inflammation, and ER stress-related apoptosis play significant roles in the pathogenesis.
PURPOSE: A composition containing VIP is provided to effectively prevent stress or mood disorders and to enhance gene expression and protect nervous cells. CONSTITUTION: A composition for preventing and treating mood disorders contains VIP(Vasoactive Intestinal Peptide) as an active ingredient. The VIP has an amino acid sequence of sequence number 1. The composition enhances BcL-2 expression and GDNF(Vasoactive Intestinal Peptide). The mood disorder includes depression(unipolar disorder), bipolar disorder I or II, or cyclothymic disorder. A composition for preventing and treating the mood disorder contains GDNF or Bcl-2 gene or protein thereof as an active ingredient.
BACKGROUND: Dengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics).
METHODS: A descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus antibodies and DENV NS1 antigen among Banadir Region residents, while a questionnaire survey was conducted to understand the clinical and demographic characteristics of the patients.
RESULTS: A total of 735 febrile patients were studied, with 55.6% men and 44.3% women. The majority of the participants were children aged 14 years and younger. Among them, 10.8% tested positive for IgM antibodies against dengue virus (DENV), while the prevalence of DENV NS1 antigen was 11.8%. Fever and myalgia were the most common symptoms observed in the DENV-positive patients.
CONCLUSIONS: A dengue fever outbreak has been confirmed in Banadir region, Somalia. This study provides information on the most affected districts and identifies risk factors contributing to DF outbreaks. The study recommends improving outbreak readiness and response, particularly in surveillance and laboratory diagnostics, by fostering intersectoral collaboration and establishing regulatory frameworks for financial and operational participation.
A mechanism is provided in a data processing system comprising at least one processor and at least one memory, the at least one memory comprising instructions which are executed by the at least one processor and configure the processor to implement a healthcare blockchain framework for continuous compliance auditing readiness and attestation in healthcare cloud solutions. The mechanisms provides a healthcare blockchain framework to create, read, update, and delete elements of a healthcare compliance model supporting a dynamic allocation of cloud resources to a healthcare business network. Compliance with one or more healthcare regulations is built into the blockchain framework. Responsive to an attestation event, a compliance attestation component within the healthcare blockchain framework reviews asset contents, state, and properties of an asset in a compliance repository. The compliance attestation component creates a bottom-up asset manifest for the asset and compares the asset manifest to a test case corresponding to an asset class of the asset. The compliance attestation component validates the asset against evidence rules corresponding to the asset class of the asset based on the comparison. Responsive to the compliance attestation component validating the asset, the mechanism generates a proof-of-validation certification.
UNLABELLED: Triggering ferroptosis, an iron-dependent form of cell death, has recently emerged as an approach for treating cancer. A better understanding of the role and regulation of ferroptosis is needed to realize the potential of this therapeutic strategy. Here, we observed extensive activation of ferroptosis in hepatoma cells and human hepatocellular carcinoma (HCC) cases. Patients with low to moderate activation of ferroptosis in tumors had the highest risk of recurrence compared to patients with no or high ferroptosis. Upon encountering ferroptotic liver cancer cells, aggregated macrophages efficiently secreted proinflammatory IL1β to trigger neutrophil-mediated sinusoidal vascular remodeling, thereby creating favorable conditions for aggressive tumor growth and lung metastasis. Mechanistically, hyaluronan fragments released by cancer cells acted via an NF-κB-dependent pathway to upregulate IL1β precursors and the NLRP3 inflammasome in macrophages, and oxidized phospholipids secreted by ferroptotic cells activated the NLRP3 inflammasome to release functional IL1β. Depleting either macrophages or neutrophils or neutralizing IL1β in vivo effectively abrogated ferroptosis-mediated liver cancer growth and lung metastasis. More importantly, the ferroptosis-elicited inflammatory cellular network served as a negative feedback mechanism that led to therapeutic resistance to sorafenib in HCC. Targeting the ferroptosis-induced inflammatory axis significantly improved the therapeutic efficacy of sorafenib in vivo. Together, this study identified a role for ferroptosis in promoting HCC by triggering a macrophage/IL1β/neutrophil/vasculature axis.
SIGNIFICANCE: Ferroptosis induces a favorable tumor microenvironment and supports liver cancer progression by stimulating an inflammatory cellular network that can be targeted to suppress metastasis and improve the efficacy of sorafenib.
Patients will begin fosphenytoin or phenytoin prophylaxis on Day -10. Patients will receive busulfan on days -9, -8, -7 and -6, cyclophosphamide on days -5, -4, -3, and -2 and rabbit antithymocyte globulin on days -4, -3, -2 and -1. The double cord blood infusion will be performed on Day 0. GVHD prophylaxis will consist of tacrolimus/MMF.
No human data are available to indicate the presence or absence of drug-associated risk. Animal reproductive studies have not been conducted with BIVIGAM. It is not known whether BIVIGAM can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Immune globulins cross the placenta from maternal circulation increasingly after 30 weeks of gestation. BIVIGAM should be given to pregnant women only if clearly needed. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively.
Heart failure with preserved ejection fraction (HFpEF) is a difficult disease to diagnose due to nonspecific symptoms and clinical findings. The disease occurs in the elderly, who often have other illnesses and signs of aging that make diagnosis of heart failure more difficult. Recently, it has been suggested that HFpEF, which has primarily been thought to be a diastolic disease, is in fact multifactorial, with elements of abnormal systolic function and increased vascular stiffness playing a role in disease pathology. No treatment has been shown to reduce the high mortality of the disease. However, few studies have evaluated this population of patients during periods of increased physiologic stress, despite the consistent clinical presentation of impaired exercise tolerance with few symptoms at rest. This study explores the multifactorial physiology of HFpEF, with a detailed investigation of the specificity of abnormalities in contractile reserve and vascular stiffness for this disease, and exploration of the modifiability of these abnormalities. The techniques used are non-invasive, involving echocardiographic evaluation of cardiac function, and measurement of arterial stiffness using tonometry. The first aim of the study is to explore the specificity of a potential diagnostic test for HFpEF by investigating the change in ejection fraction before and after β-adrenergic stimulation with low-dose dobutamine in HFpEF compared to other groups important to distinguish clinically, specifically patients with shortness of breath due to pulmonary disease, and those with hypertension and left ventricular hypertrophy without clinical heart failure. In the second aim, the study will investigate the ability of the calcium channel blocker, amlodipine, to restore normal contractile responses of the myocardium. In the third aim, the role of arterial stiffness in drug responses in HFpEF will be explored. It is anticipated that improved understanding of the complex physiology of this multifactorial disease gained through this study will lead to more rational design of large clinical trials studying promising agents for HFpEF that impact not only diastolic function, but contractile reserve and arterial properties as well.
A medical data analysis system integrating structured image data. The system comprises an image information structuring module, an integration and preprocessing module, and a machine learning algorithm module. According to the invention, on the basis of a distributed data analysis platform using Spark and Hadoop, and to address the difficulty of both integrating medical image data with structured data residing in electronic medical records and analyzing same, an image information structuring module is used to analyze medical image data by means of computer vision technology and used to perform structuring conversion on key information. Said data is then integrated with structured data of the relevant patient, the structured data including relevant diagnostic information and demographic information from an electronic medical records system; missing value processing and classification data conversion is performed by means of a data preprocessing module; and data analysis and results visualization are carried out using a machine learning algorithm module. A highly efficient medical data analysis system is thus formed. The invention increases the utilization rate of various types of multi-dimensional medical data, and satisfies the various topical research requirements of researchers.
The invention discloses a medicament for treating burn and scald. The medicament comprises aqueous agent for coating, wherein the aqueous agent is soaking solution obtained by soaking dittany bark, corktree bark, cotton rose flower, beautyberry, borneol, golden thread and wild jujubes into alcohol. The medicament also comprises medicinal powder for external application, wherein the medicinal powder is formed by grinding processed strychnos, borneol and dragon's blood into superfine powder and mixing and sterilizing the powder. For pyogenic infection of a patient, the medicinal powder is externally applied to the burn or the scald. The medicament can quickly relieve the initial sharp pain caused by the burn and the scald, and the searing pain is obviously relieved after the medicament is used for 5 to 8 minutes for I and II degrees. The medicament can effectively prevent medium-term infection under scab. The medicament has short treatment period and does not left scars after healing, and even the scars left by I and II-degree burn and scald are not too obvious. The medicament is particularly suitable for I and II-degree burn and scald, and the III-degree or large-area burn and scald are suggested to be treated by combining Chinese (the medicament of the invention) and western medicaments.