anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Newborns are particularly susceptible to infection in hospitals, with neonatal sepsis being the most common infection symptom and the third leading cause of neonatal death. Klebsiella pneumoniae is a gram-negative bacterium of Enterobacteriaceae, which is a common pathogen of neonatal septicemia. In this study, we will analyze and evaluate the current status, clinical characteristics, and drug resistance of Klebsiella pneumoniaesepsis infection in Neonatal Intensive Care Unit (NICU), with the aim of providing effective basis for timely and accurate clinical diagnosis and treatment in clinical practice.
METHODS: Statistical analysis was performed on 75 cases of Enterobacteriaceae septicemia in infants admitted to NICU in a special obstetrics and gynecology hospital in Shanghai from January 2020 to June 2022. Based on bacterial identification, isolates were divided into the Klebsiella pneumoniae (KP) group (n = 49) and the non-KP Enterobacteriaceae group (n = 26). The infection, clinical characteristics, and bacterial resistance of the two groups of infected patients were compared.
RESULTS: Comparing the clinical characteristics of the two groups, the results showed that most of the subjects in the KP and non-KP groups were premature infants, accounting for 100% and 92.3% of subjects, respectively; late onset was the main disease in both groups, accounting for 93.9% and 80.8% of subjects, respectively. All patients received Peripherally Inserted Central Catheter(PICC). The levels of pro calcitonin and CRP (C-reactive protein) were significantly higher in the KP group compared with those in the non-KP group (p < .05). At the same time, the incidence of thrombocytopenia in the KP group was significantly higher than that in the non-KP group (p < .05). The proportion of antimicrobial drug exposure in the KP group is higher than that in the non-KP group. The drug resistance of the KP group to ceftazidime, ceftriaxone, cefepime, ampicillin/sulbactam, aztreonam, ciprofloxacin and compound sulfamethoxazole was significantly higher than that of the non-KP group, whereas the drug resistance rate to cefotetan, gentamycin and to bramycin was significantly lower than that of the non-KP group, Statistically significant differences (p < .05). 38 cases of Klebsiella pneumoniae producing ESBLs were tested for related resistance genes. The results showed that the main resistance types were SHV and TEM, with detection rates of 60.6% and 28.9%.
CONCLUSIONS: This study shows that neonatal sepsis caused by Klebsiella pneumoniae infection has a high incidence and drug resistance in premature and low birth weight infants, and has become a serious public health problem; Clinicians should pay attention to differential diagnosis, Reasonable selection of antibiotics to reduce the generation of drug-resistant bacteria.
HIV-infected pregnant women ≥ 20 weeks gestation NOT on tuberculosis treatment who received tenofovir alafenamide fumarate (TAF) 25 mg q.d. with cobicistat (COBI) or ritonavir (RTV) boosting.
PURPOSE: This study investigates a real-world multicenter cohort of patients with urinary tract cancer (UTC), with primary disease sites including the bladder, urethra, and upper tract, who enrolled for research molecular testing of their germline and tumor. The purpose of this study was to evaluate factors that could affect the likelihood of identifying a clinically actionable germline pathogenic variant (PV).
METHODS: Patients with UTC were identified from 10 cancer institutes of the Oncology Research Information Exchange Network consortium. The data set comprised abstracted clinical data with germline and tumor genomic data, and comparative analyses were conducted.
RESULTS: Clinically actionable germline PVs in cancer predisposition genes were identified in 16 (4.5%) of 354 patients. A higher proportion of patients with the urethra and the upper tract as the primary sites of disease had PVs with a prevalence of 11% (5/45), compared with only 3.6% (11/308) in those with the bladder as the primary site of disease (P = .04). There were no significant differences in markers of genomic instability (such as tumor mutational burden, microsatellite instability [MSI], and loss of heterozygosity, copy number, and chromosomal instability) between those with PVs and those without (P > .05). Of the PVs identified, 10 (62%) were in homologous recombination repair (HRR) genes, three (19%) in mismatch repair (MMR) genes, and three (19%) in genes associated with other pathways.
CONCLUSION: Tissue-based assessment of genomic instability, such as MSI, does not reliably indicate germline PV. A comprehensive clinical germline testing approach that includes HRR genes in addition to MMR genes is likely to yield PVs in approximately one of 10 patients with nonbladder primary disease sites such as the upper tract and the urethra.
This is the group that will receive laparoscopic pancreaicoduodenectomy trocars were inserted (between 5 and 6 trocars were required) and pneumoperitoneum induction was done. The surgeries were performed as previously described . Single loop reconstruction was adopted which involved the formation of all three anastomoses (pancreatico-jejeunostomy, hepatico-jejeunostomy, and gastro-jejeunostomy) on a single jejunal loop. The distance between the hepatico-jejeunostomy, and gastro-jejeunostomy was adjusted at 60 cm for all patients.
Patients will be assigned to one of two groups according to the block randomization list, given a sequence number according to the date and time of admission. In addition to the clinical routine application, cold gel pack application will be applied to the patients in Group 1, and the clinical routine application will continue for those in Group 2. To collect data, the Patient Diagnosis Form developed by the researcher in line with literature information, the Visual Analog Scale for Itching, the Bates-Jensen Wound Assessment Tool and the 12-Item Itching Severity Scale, whose validity and reliability analysis has been conducted, will be used. Calculation of the sample size of the study was made with the G.Power (v3.1.7) computer program. In the study of Joo et al., a total of 26 patient samples were used to represent the universe, assuming that the difference in two independent groups was considered statistically significant according to the itching degree averages of burn patients (α = 0.05 significance level and 95% power). During the research process, it was decided to include a total of 60 individuals in the sample, with 30 patients in Group-1 (Experiment) and 30 patients in Group-2 (Control), taking into account possible losses.
The effect of hepatic impairment on the pharmacokinetics of buprenorphine and naloxone has been evaluated in a pharmacokinetic study. Both drugs are extensively metabolized in the liver. While no clinically significant changes have been observed in subjects with mild hepatic impairment; the plasma levels have been shown to be higher and half-life values have been shown to be longer for both buprenorphine and naloxone in subjects with moderate and severe hepatic impairment. The magnitude of the effects on naloxone are greater than that on buprenorphine in both moderately and severely impaired subjects. The difference in magnitude of the effects on naloxone and buprenorphine are greater in subjects with severe hepatic impairment than in subjects with moderate hepatic impairment, and therefore the clinical impact of these effects is likely to be greater in patients with severe hepatic impairment than in patients with moderate hepatic impairment. Buprenorphine/naloxone products should be avoided in patients with severe hepatic impairment and may not be appropriate for patients with moderate hepatic impairment [see Warnings and Precautions (5.12), and Clinical Pharmacology (12.3)].
Cervical cancer, a prevalent malignancy in the female reproductive tract, exhibits a high incidence. Existing evidence indicates a robust correlation between alterations in vaginal flora composition and the progression of cervical cancer. Nevertheless, there is a lack of clarity concerning the specific microorganisms within the vaginal microbiota that are linked to the onset and development of cervical cancer, as well as the mechanisms through which they exert carcinogenic effects. The 16 S ribosomal (rRNA) and metagenomic sequencing technology were used to analyze vaginal microorganisms, and screening for human papillomavirus (HPV) positive cervical cancer-associated microbial markers using fold change in mean bacterial abundance. Moreover, vaginal microenvironmental factors were detected, and the local vaginal inflammatory state in patients with cervical cancer was subjected to assay via qRT-PCR and ELISA. The hub inflammatory genes were screened by transcriptome sequencing after co-culture of bacteria and normal cervical epithelial cells, and an in vitro model was utilized to assess the impacts of inflammatory factors on cervical cancer. Both cervical cancer patients and HPV-positive patients showed significant changes in the composition of the vaginal flora, characterised by a decrease in the abundance of Lactobacillus and an increase in the abundance of a variety of anaerobic bacteria; The microbial sequencing identified Porphyromonas, Porphyromonas_asaccharolytica, and Porphyromonas_uenonis as microbial markers for HPV-associated cervical cancer. Vaginal inflammatory factors in patients with cervical cancer were overexpressed. After Porphyromonas_asaccharolytica intervention on cervical epithelial H8 cells, interleukin (IL)-1β, a hub differential gene, markedly promoted tumor-associated biological behaviors at the in vitro cytological level in cervical cancer. This study for the first demonstrated that Porphyromonas, Porphyromonas_asaccharolytica, and Porphyromonas_uenonis could serve as novel microbial markers for cervical cancer. Moreover, Porphyromonas_asaccharolytica was identified as having the ability to induce the overexpression of inflammatory genes in cervical epithelial cells to create a favorable microenvironment for the onset and development of cervical cancer. The effects of dysbacteriosis on cervical cancer were microbiologically elucidated.
PURPOSE:To obtain the title granules causing no prolonged disintegration time thereof due to its hardening by incorporating fine silicon dioxide powder in an aqueous binder solution or water as kneading liquid. CONSTITUTION:A mixture comprising, based on the final granules, (A) 40-90wt.% of pancreatin, (B) a shaping agent such as lactose or starch, (C) <=15wt.% of a disintegrating agent (e.g. hydroxypropyl cellulose of low substitution degree), (D) 3-20wt.% of fine silicon dioxide powder, and (E) small amounts of coloring matter, lubricant, etc., is incorporated with an aqueous solution containing 1-10wt.%, based on the final granules, of a binder (e.g. water-soluble cellulose derivative, water-soluble vinyl polymer) followed by kneading. The product is then extruded using an extruder to obtain the objective readily disintegrable granules. When said binder is mixed, in advance, directly in the form of powder, the kneading is made by addition of water alone. A pharmaceutical preparation produced by coating the present granules with an enteric base will transfer from the stomach to the intestine through the digestive tract and be rapidly disintegrated at the upper part of the small intestine, thus being expected to adequately give medicinal virtues.
BACKGROUND: Sexually transmitted infections (STI) are public health problems in Ethiopia. Women have a higher chance of acquiring STI. STI complications are more severe in women compared to men. Despite that, treatment seeking for STI among women is poor. Woman empowerment and gender related factors may be playing a role for treatment seeking practice for STI. However, there are no studies that assess the association between these factors and treatment seeking practice for STI among married reproductive age women in Ethiopia. Therefore, this analysis was designed to explore this association in Ethiopia.
METHODS: This analysis used the 2016 Ethiopian demographic and health survey (EDHS) data. The 2016 EDHS collected data about STI treatment seeking practice for STI among other variables. Data was analyzed using STATA 17.0. Sampling weights were applied to improve the representativeness of the samples. Descriptive statistics were computed to describe the characteristics of the women. Binary and multivariable logistic regression models were fitted to identify the association between treatment seeking practice for STI and predictor variables. Multicollinearity was checked using variance inflation factors before running the multivariable logistic regression.
RESULTS: In this study, about 28% (95%CI: 20.87, 36.77) married reproductive age women with STI or STI symptoms sought treatment from the formal sector. Women whose husband attended secondary and higher education (AOR, 8.52; 95%CI 1.42, 51.21), and women with higher women empowerment scores (AOR 1.38, 95%CI 1.06, 1.81) had higher odds of treatment seeking for STI or STI symptoms. On the other hand, women who believe wife beating is justified had lower odds (AOR 0.32; 95%CI 0.15, 0.68) of treatment seeking for STI or STI symptoms.
CONCLUSIONS: Treatment seeking practice for STI among married reproductive age women in Ethiopia is low. The Ministry of Health and development partners shall conduct further research to identify barriers for treatment seeking practice. Gender variables (women empowerment and belief that wife beating is justified) were significantly associated with STI treatment seeking practice among married reproductive age women. STI prevention and control strategies shall include women empowerment and gender issues as essential component in STI prevention, treatment, and control activities.
PURPOSE:A cosmetic, containing a mucopolysaccharide and polyoxyalkylene alkyl glucoside ether, having enhanced humectant effect and good stability and safety without stickiness. CONSTITUTION:A cosmetic containing (A) 0.001-5wt%, preferably 0.1-1wt% mucopolysaccharide and (B) a polyoxyalkylene alkyl glucoside ether in an amount of twice or more based on the mucopolysaccharide. The feeling of use with strong stickiness of the component (A) is improved and humectant effect is enhanced by the use of the component (B) together. The component (A) is selected from hyaluronic acid, chondroitin-4-sulfate, dermatan sulfate, keratan sulfate or heparin, etc. The average number of added mol of the ethylene oxide and/or propylene oxide of the component (B) is preferably 5-40mol in total. The dosage form of the cosmetic is optional and widely usable as foundation cosmetic, make-up cosmetic or hair cosmetic, etc.
Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The objective of this study was to examine in depth the genetic relationships between CRP and GlycA as well as between each of them and other selected cytokines, which may shed light on the mechanisms of inflammageing. Using the Olink 96 Inflammation panel, data on inflammatory mediators for 1518 twins from the TwinsUK dataset were acquired. Summary statistics for genome-wide association studies for several cytokines as well as CRP and GlycA were collected from public sources. Extensive genetic correlation analyses, colocalization and genetic enrichment analyses were carried out to detect the shared genetic architecture between GlycA and CRP. Mendelian randomization was carried out to assess potential causal relationships. GlycA predicted examined cytokines with a magnitude twice as great as that of CRP. GlycA and CRP were significantly genetically correlated (Rg = 0.4397 ± 0.0854, p-value = 2.60 × 10-7). No evidence of a causal relationship between GlycA and CRP, or between these two biomarkers and the cytokines assessed was obtained. However, the aforementioned relationships were explained well by horizontal pleiotropy. Five exonic genetic variants annotated to five genes explain the shared genetic architecture observed between GlycA and CRP: IL6R, GCKR, MLXIPL, SERPINA1, and MAP1A. GlycA and CRP possess a shared genetic architecture, but the relationship between them appears to be modest, which may imply the promotion of differing inflammatory pathways. GlycA appears to be a more robust predictor of cytokines compared to CRP.
BACKGROUND: Little is known about the effects of night shifts and their interactions with genetic factors on chronic obstructive pulmonary disease (COPD). In this study, we aim to investigate relationships between long-term night shift work exposure and COPD risk, and assess modification effects of genetic predisposition.
METHODS: A total of 277,059 subjects who were in paid employment or self-employed were included in the UK Biobank. Information on current and lifetime employment was obtained, and a weighted COPD-specific genetic risk score (GRS) was constructed. We used Cox proportional hazard models to investigate associations between night shift work and COPD risk, and their interaction with COPD-specific GRS.
RESULTS: The cohort study included 277,059 participants (133,063 men [48.03%]; mean [SD] age, 52.71 [7.08] years). During a median follow-up of 12.87 years, we documented 6558 incidents of COPD. From day work, irregular night shifts to regular night shifts, there was an increased trend in COPD incidence (P for trend < 0.001). Compared with day workers, the hazard ratio (HR) and 95% confidence interval (CI) of COPD was 1.28 (1.20, 1.37) for subjects with rarely/sometimes night shifts and 1.49 (1.35, 1.66) for those with permanent night shifts. Besides, the longer durations (especially in subjects with night shifts ≥ 10 years) and increasing monthly frequency of night shifts (in workers with > 8 nights/month) were associated with a higher COPD risk. Additionally, there was an additive interaction between night shifts and genetic susceptibility on the COPD risk. Subjects with permanent night shifts and high genetic risk had the highest risk of COPD (HR: 1.90 [95% CI: 1.63, 2.22]), with day workers with low genetic risk as a reference.
CONCLUSIONS: Long-term night shift exposure is associated with a higher risk of COPD. Our findings suggest that decreasing the frequency and duration of night shifts may offer a promising approach to mitigating respiratory disease incidence in night shift workers, particularly in light of individual susceptibility.
1333826 Hydrorefining oils ESSO RESEARCH & ENG CO 11 Jan 1971 [16 Feb 1970] 1296/71 Heading C5E A colourless and odourless oil for cosmetics is made by refining a heavy alkylate bottoms oil, having a boiling range between 540‹ and 800‹ F., a viscosity at 100‹ F. between 75 SSU and 3000 SSU and a viscosity index between 0 and - 200, in a hydrogen-refining zone in the presence of a sulphur-insensitive catalyst at 400-700‹ F., a hydrogen pressure of 150- 2000 p.s.i.g., a liquid hourly space velocity of 0À1-20 and 100-1000 s.c.f. of hydrogen per barrel and then hydrogenating the hydrogen refined oil in the presence of a Group VIII metal catalyst at 300-650‹ F., a hydrogen pressure of 300-3000 p.s.i.g., a liquid hourly space velocity of 0À1-3 and 300-2500 s.c.f. of hydrogen per barrel. Suitable hydrogen-refining catalysts are molybdenum disulphide, molybdenum oxide or cobalt molybdate on alumina. Suitable hydrogenation catalysts are platinum, palladium, rhodium or nickel on kieselguhr. A heavy alkylate bottoms oil by-product of the sulphuric acid catalysed isobutane or isopentane alkylation of C 3  to C 5  olefins is distilled at 12 and 16 to provide a stream 19 which is refined at 20 and then hydrogenated at 24. The stream 19 can be a single boiling-range fraction or a blend of several such fractions.
PURPOSE:To prepare the subject composition comprising amorphous SiO2-Al2O3 powder, an alkali metal silicate salt, water and a specific medicinally active ingredient such as a perfume, having an excellent sustained release property for the medicinally active ingredient in a molded product excellent in designability, and excellent in productivity. CONSTITUTION:This composition contains 100 pts.wt. of amorphous SiO2Al2O3 powder (e.g. fly ash having a SiO2/Al2O3 compounding ratio of 10-90/90-100, an alkali metal silicate salt (preferably having a SiO2/R2O molar ratio of 0.05-2.5) preferably in an amount of 50-500 pts.wt. (as an aqueous solution), water preferably in an amount of 10-400 pts.wt., and one or more medicinally active ingredients selected from the group of a perfume (e.g. a lemon oil or orange oil), an aromatic agent, an insect-proof agent (e.g. peppermint oil), an insecticide (e.g. pyrethrin or parathion), and a repellent (e.g. citral or diethyltoluamide).
This systematic literature review explored the relationship between hearing loss, the use of hearing aids or cochlear implants, and late-deafened adults' perception and appreciation of, and participation in, music. To identify articles, four databases were searched, MEDLINE, Scopus, Embase, and American Psychological Association (APA) PsycINFO, using terms associated with hearing loss, hearing aids, cochlear implants, music perception, appreciation, or participation. The included studies were empirical, written in English, peer reviewed, used any research method, had no date restrictions, and involved late-deafened adults. A formal risk of bias evaluation was undertaken using the Joanna Briggs Institute (JBI) Critical Appraisal tools. A double-blind review of 2595 articles was completed in June 2023, with a total of 131 studies meeting the inclusion criteria. Typically, the reviewed articles focused on music perception testing. The studies included more than 6900 adult participants with hearing loss. Data relating to the review question were extracted and thematically coded. Only 18 studies reported on music experiences for adults who had hearing loss with or without hearing aids. The remaining 113 articles related to cochlear implant users, and 91 of these focused primarily on identification of musical structural components. The reviewed articles consistently established that hearing loss and hearing devices have a substantial, generally negative, impact on music perception. The psychosocial and emotional need for music was mostly overlooked, with few studies focusing on music appreciation, enjoyment, social connectedness, or participation. Further research is needed to understand the broader context of how hearing loss and hearing devices impact personal experiences including mental and physical well-being and quality of life.
PURPOSE: To provide a method for producing a solid enteric pharmaceutical preparation excellent in acid resistance by which a medicine is coated with a coating liquid containing a dispersed polymer having <=1μm average particle diameter. CONSTITUTION: A cellulosic polymer is dissolved in an organic solvent mixable with water in an optional proportion or a mixed solvent thereof with water to prepare a polymer solution. which is subsequently mixed with water. The organic solvent is then removed to provide a concentrate. An anionic surfactant is subsequently added to the resultant concentrate and the prepared mixture is dried to afford a polymer powder. which is then charged into water to thereby afford an emulsion containing the polymer dispersed into <=1μm average particle diameter. The resultant emulsion is subsequently dispersed in water containing a plasticizer to provide a coating liquid. A medicine is coated with the coating liquid to complete the production of a solid enteric pharmaceutical preparation.