anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a drug or food composition to prevent or treat diabetes or obesity comprising leaf extracts of Peucedanum japonicum Thunb. as the valid ingredient and having the effect of α-glucosidase degradation. In the present invention, leaf extract of Peucedanum japonicum Thunb. relates to the alpha-glucosidase inhibition activity material obtained by extracting or segmenting leaves of Puecedanum japonicum Thunb. with oily solvent. In addition, the leaf extract of Pecuedanum japonicum Thunb. includes all of the refined, extracted or segmented materials that are condensed or dried beside the extracted or segmented material of the leaves.
Patients using topical corticosteroids should receive the following information and instructions.   
1\. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.   
2\. Patients should be advised not to use this medication for any disorder other than for which it was prescribed.   
3\. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.   
4\. Patients should report any signs of local adverse reactions especially under occlusive dressing.   
5\. Parents of pediatric patients should be advised not to use tight fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.
Alcohol-associated hepatitis (AH) is a critical condition with high mortality rates and is worsened by infections. Organ failure is strongly associated with intestinal dysbiosis. Emerging research suggests that gut microbiota modulation with probiotics can improve AH outcomes. This study investigated the clinical and microbiome effects of high-dose probiotic infusion (HDPI) compared with corticosteroid therapy (CST) and fecal microbiota transplantation (FMT) in severe AH. Patients with biopsy-proven severe-AH were enrolled from March 2019 to June 2020 and matched for age and disease severity. The patients received HDPI (n = 20), FMT (n = 16), or CST (n = 14). HDPI consists of a potent probiotic mix delivered via a nasoduodenal tube for 6 days. The primary outcome was survival at 90-days. Stool samples were subjected to 16S and 18S rRNA sequencing to assess significant bacterial and fungal taxa and their interactions at baseline and post treatment. At 90-days, survival rates were 55%, 64.3%, and 87.5% (HDPI, CST, respectively). HDPI did not beneficially impact bacterial alpha-diversity but significantly altered beta-diversity. Notably, the number of pathogenic bacteria, such as Bilophila and Roseburia increased. Fungal analysis revealed no significant changes in alpha diversity, but significant dissimilarities in beta diversity post-HDPI. New fungal genera such as Basidiomycota and Phragmoplastophyta have emerged, with significant deleterious expansion in fungal communities and damaging modifications between fungal-bacterial interactions. HDPI failed to outperform CST in improving the clinical outcomes of patients with severe AH. While HDPI influenced both bacterial and fungal microbiomes, it also led to the persistence of pathogenic communities. FMT showed superior survival outcomes, highlighting the urgent need for further controlled trials.
Obesity is a critical public health issue, necessitating effective weight loss interventions. While various dietary regimens have been explored, individual responses to interventions often vary. This study involved a 3-month dietary intervention aiming at assessing the role of macronutrient composition and the potential role of genetic predisposition in weight loss among Greek adults. This randomized clinical trial followed the CONSORT principles, recruiting 202 participants overall; 94 received a hypocaloric, high-protein diet and 108 received a high-carbohydrate, hypocaloric diet. Genetic predispositions were assessed through 10 target variants known for their BMI associations. Participants' weight and BMI values were recorded at baseline and post-intervention (n = 202 at baseline, n = 84 post-intervention) and an imputation method was applied to account for the observed missing values. Participants experienced a statistically significant weight loss across all dietary regimens (p < 0.001). Genetic analyses did not display statistically significant effects on weight loss. No significant differences in weight loss were observed between macronutrient groups, aligning with the POUNDS Lost and DIETFITS studies. This study underscores the importance of dietary interventions for weight loss and the potential contributions of genetic makeup. These findings contribute to obesity management within the Greek population and support the need for further research in personalized interventions.
Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights the mismatch between our Paleolithic-optimized genes and modern diets, which led to the dramatically increased prevalence of CKD in modern societies. In particular, the Standard American Diet (SAD), high in carbohydrates and ultra-processed foods, causes conditions like type 2 diabetes (T2D), chronic inflammation, and hypertension, leading to CKD. Autosomal dominant polycystic kidney disease (ADPKD), a genetic form of CKD, is characterized by progressive renal cystogenesis that leads to renal failure. This review challenges the fatalistic view of ADPKD as solely a genetic disease. We argue that, just like non-genetic CKD, modern dietary practices, lifestyle, and environmental exposures initiate and accelerate ADPKD progression. Evidence shows that carbohydrate overconsumption, hyperglycemia, and insulin resistance significantly impact renal health. Additionally, factors like dehydration, electrolyte imbalances, nephrotoxin exposure, gastrointestinal dysbiosis, and renal microcrystal formation exacerbate ADPKD. Conversely, carbohydrate restriction, ketogenic metabolic therapy (KMT), and antagonizing the lithogenic risk show promise in slowing ADPKD progression. Addressing disease triggers through dietary modifications and lifestyle changes offers a conservative, non-pharmacological strategy for disease modification in ADPKD. This comprehensive review underscores the urgency of integrating diet and lifestyle factors into the clinical management of ADPKD to mitigate disease progression, improve patient outcomes, and offer therapeutic choices that can be implemented worldwide at low or no cost to healthcare payers and patients.
The eligible patients received 14-day concomitant therapy, including vonoprazan and three kinds of antibiotics according to the previous eradication regimens and antibiotic use. Antibiotics are selected from Amoxicillin, Tetracycline, Furazolidone, Levofloxacin, Clarithromycin, Tinidazole, Metronidazole.
The study aims to determine whether concentrated beetroot juice has an acute effect on isometric strength of the knee muscles and the rate of force development in knee extension, as well as endurance of the same muscle. This will be a cross-over study. 20 subjects will be randomly selected to the experimental group or control group; after 1 week, participants will repeat the measurements in the other condition. Subjects will consume 140 ml of beetroot juice extract 2.5 hours before the measurement or placebo (140 ml of blackcurrant juice with added appropriate amount of sugar to equalize the carbohydrate value and lemon juice fort the taste). An isometric dynamometer will be used to measure the isometric strength of the knee extensors. Investigators will quantify peak force, rate of force development, endurance of knee extensors at 50 % of the maximal force, and the force recovery after a fatiguing protocol.
The present invention relates to an extraction method for golden thread evodia rutaecarpa total alkaloid and a preparation of the golden thread evodia rutaecarpa total alkaloid. The extraction method is characterized in that after 6 portions of golden thread and one portion of evodia rutaecarpa are respectively pulverized into golden thread coarse powder and evodia rutaecarpa coarse powder which are mixed, and processed through the step of alcohol reflux extraction, alcohol is recovered. Thick paste is extracted by ethyl acetate recovered, and an extract is obtained; medicine dregs obtained after the alcohol reflux is carried out is added with water for being filtrated, decocted and concentrated, and a concentrated solution is obtained; a water solution after extracted and the concentrated solution are filtrated, the pH value of a filtered solution is regulated to 1.0 to 4.0 by hydrochloric acid, and NaCl is added to the solution for making the content of the solution from 5% to 10%. The NaCl and the solution are stirred for dissolving the NaCl, stewing and filtration are carried out, deposited matters are washed by water until the pH value is from 4.0 to 7.0, and an extract is obtained. The extracts are combined, pressure reduction drying and pulverization are carried out, and an extract, i.e. the golden thread evodia rutaecarpa total alkaloid is obtained. The golden thread evodia rutaecarpa total alkaloid extracted with the method has the pharmacological functions of gastritis resistance, gastric ulcer resistance, analgesia, etc. The content of the total alkaloid of the golden thread evodia rutaecarpa total alkaloid is larger than 60%, the content of berberine hydrochloride in the total alkaloid is 60%, and other alkaloid accounts for 40%. The method is easy to operate, has low cost and can be easily prepared into various preparations.
Placebo Group: In this group the participants received TENS with frequency of 75Hz, pulse duration of 200 microseconds. The stimulation time will be for only 10s.
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to abdominal pain in inflammatory bowel disease (IBD). Previous attempts at blocking these channels have been riddled with side effects. Here, we propose a novel treatment strategy, utilizing the large pore of TRPV1 channels as a drug delivery system to selectively inhibit visceral nociceptors.
METHODS: We induced colitis in rats using intrarectal dinitrobenzene sulfonic acid. Visceral hypersensitivity, spontaneous pain, and responsiveness of the hind paws to noxious heat stimuli were examined before and after the intrarectal application of membrane-impermeable sodium channel blocker (QX-314) alone or together with TRPV1 channel activators or blockers.
RESULTS: Intrarectal co-application of QX-314 with TRPV1 channel activator capsaicin significantly inhibited colitis-induced gut hypersensitivity. Furthermore, in the model of colitis, but not in naïve rats, QX-314 alone was sufficient to reverse gut hypersensitivity. The blockade of TRPV1 channels prevented this effect of QX-314. Finally, applying QX-314 alone to the inflamed gut inhibited colitis-induced ongoing pain.
CONCLUSIONS: Selective silencing of gut nociceptors by a membrane-impermeable sodium channel blocker entering via exogenously or endogenously activated TRPV1 channels diminishes IBD-induced gut hypersensitivity. The lack of effect on naïve rats suggests a selective analgesic effect in the inflamed gut. Our results suggest that in the colitis model, TRPV1 channels are tonically active. Furthermore, our results emphasize the role of TRPV1-expressing nociceptive fibers in colitis-induced pain. These findings provide proof of concept for using charged activity blockers for the blockade of IBD-associated abdominal pain.
Re-irradiation consisting of hyperfractionated IMRT, 40.8 Gy in 1.2 fractions twice daily 5/7 days weekly, with oral capecitabine 825 mg/m2 BID on radiotherapy treatment days. Re-staging performed 4-6 weeks after the last dose, followed by surgery, when feasible.
A method and system for automated classification of distinction between normal lungs and abnormal lungs with interstitial disease, based on the analysis of predetermined physical texture measures and also on a data base for normal lungs of these texture measures. The texture measures selected are the RMS variation, R, and the first moment of power spectrum, M, for lung texture. These two texture measures are normalized by using the data base for normal lungs. A single texture index is determined from the two normalized texture measures by taking into account the distribution (or the data base) of texture measures obtained from abnormal lungs, in order to facilitate the automated classification of normal and abnormal lungs. A threshold texture index is then chosen for initial selection of "abnormal" regions of interest (ROIs), which contain a large texture index above the threshold level. The selected abnormal ROIs are then subjected to three independent tests for a (1) definitely abnormal singular pattern, (2) localized abnormal pattern for two or more abnormal clustered ROIs, and (3) diffuse abnormal pattern for more than four abnormal ROIs distributed through the lung. A chest image containing any one of these abnormal patterns is classified as showing an abnormal lung with interstitial disease.
<P>PROBLEM TO BE SOLVED: To provide a solution of a problem that although Fuscoporia obliqua having functions such as a high antioxidant property has been attracting attention recently, conventional methods of using Fuscoporia obliqua cannot be said to make full use of effective ingredients thereof and the effects have not been provided sufficiently.  <P>SOLUTION: The conventional method of using Fuscoporia obliqua is a method of crushing fungus bodies thereof, extracting the same with hot water. In order to overcome the difficulty in the extraction from the fungus bodies, Fuscoporia obliqua is subjected to liquid culture, and a culture supernatant thereof is used. Further, malted rice or rice bran is added to the culture supernatant of Fuscoporia obliqua and the mixture is fermented with lactic acid bacteria. With such procedures, a composition having a function such as a higher antioxidant property can be obtained. In addition, it was found that a composition obtained by fermenting only malted rice or rice bran with lactic acid bacteria also had an antioxidant property.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Copolymers are made which consist of acrylamide and N-tert.-butylacrylamide in weight proportions of 3:7 to 8:2.  The monomers are preferably copolymerized in aqueous solution with the addition of an organic solvent miscible with water, e.g. methanol, ethanol, isopropanol, acetone and dioxane, and a catalyst such as a persulphate, hydrogen peroxide, benzoyl, diacetyl, cumene, cyclohexanone or lauroyl peroxides, azobisisobutyronitrile, or a redox system, e.g. a mixture of a persulphate and sodium bisulphite, pyrosulphite, dithionite or formaldehyde sulphoxylate.  The catalyst may be added gradually or portionwise to the reaction mixture.  At the end of polymerization the copolymer may be recovered by drying or by precipitation, or, if if it is desired to obtain an aqueous solution of copolymer, the solvent may be removed from the reaction mixture by heating in vacuo.  The copolymers are used for thickening mixtures of water and organic solvents which are miscible with water, e.g. C1-C3 alkanols, ethylene glycol and its monoethyl ether, acetone, dioxane glycerine and dimethyl formamide.
Stroke remains the 4th cause of death in Singapore and despite advances in neuro-medical care and rehabilitation, 40-50% of stroke survivors are left with permanent neuro-disability and a reduced quality of life. The previous 2 decades has seen exponential leaps in the development of rehabilitation technologies which enhance neuroplasticity and rehabilitation outcome. One of these potentially useful technologies is nBETTER System, was developed by Institute for Infocomm Research, Agency for Science, Technology and Research (A\*STAR). nBETTER is a portable, internet-connected device that detects the imagination of movement of stroke-affected limb using a Electroencephalography (EEG)-based Brain-Computer Interface (BCI) thus delivering visually engaging feedback for directed neurofeedback aimed at improving upper limb recovery for subacute to chronic stroke patients. The pilot study aims to recruit 13 patients using a multi centre trial design to investigate nBETTER system feasibility and safety for rehabilitation of subacute to chronic stroke patients with upper limb motor impairment and to determine clinical efficacy, safety and feasibility of such a system when it is delivered with standard occupational therapy.

The investigators primary hypothesis is that nBETTER is a feasible and safe prototype in stroke survivors (\> 3 months) with moderate to severe arm impairment (FMMA 10-50). The primary outcome is a gain of 15% in Fugl-Meyer motor scores at 6 weeks after 18 sessions (total of 27 hours) of supervised training by occupational therapists and bioengineers.
The present invention relates to a stick-type shampoo comprising: a housing having a guide protrusion formed on an inner circumferential surface thereof and a through hole formed on a bottom surface thereof; a lifting member inserted and coupled into the housing, and provided with a guide groove slid and coupled to the guide protrusion; a rotary handle formed on a lower surface of the housing, and provided with a helical protrusion coupled into the housing; and a replacement shampoo inserted and fixed on the helical protrusion in the housing to be tightly fixed on an upper surface of the lifting member. The helical protrusion is rotated by rotation of the rotary handle to lift and move the lifting member. Accordingly, the guide groove of the lifting member is lifted and moved along the guide protrusion, and the replacement shampoo is exposed in an upward direction of the housing. According to the present invention, the replacement shampoo is exposed in the upward direction of the housing by a simple operation of rotating the rotary handle to provide a convenient method of use. The rotary handle can be rotated in the reverse direction after using the replacement shampoo to reposition the replacement shampoo into the housing. Specifically, all of the replacement shampoo can be used up by easily exposing a small amount of the replacement shampoo remaining on the lifting member in the upward direction of the housing. The replacement shampoo can be easily refilled by a simple operation of inserting the replacement shampoo into the helical protrusion in the housing to place the replacement shampoo on the upper surface of the lifting member. Accordingly, the amount of use of the remaining shampoo is increased and shampoo purchase expenses are reduced to improve product reliability.
Androgens are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate and in women who are or may become pregnant. When administered to pregnant women, androgens cause virilization of the external genitalia of the female fetus. This virilization includes clitoromegaly, abnormal vaginal development, and fusion of genital folds to form a scrotal-like structure. The degree of masculinization is related to the amount of drug given and the age of the fetus and is most likely to occur in the female fetus when the drugs are given in the first trimester. If the patient becomes pregnant while taking androgens, she should be apprised of the potential hazard to the fetus.  
  
This preparation is also contraindicated in patients with a history of hypersensitivity to any of its components.
INTRODUCTION: Neck pain is a common problem that severely affects physical and mental health. While musculoskeletal manipulations are recommended as the first-line treatment for adults with neck pain, the comparative effectiveness of different musculoskeletal manipulations remains unclear. This systematic review and network meta-analysis of randomised controlled trials (RCTs) will compare the effectiveness of different types of musculoskeletal manipulations, with the overarching aim of guiding clinical practice.
METHODS AND ANALYSIS: Two independent reviewers will search four English electronic databases (Web of Science, Cochrane Library, EMBASE, PubMed) and three Chinese electronic databases (China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang) for relevant RCTs published from 1 January 2013 to 30 April 2023. The Clinical Trials Registry (ClinicalTrials.gov) will be searched for completed but unpublished RCTs. English and Chinese will be used to search English databases and Chinese databases, respectively. RCTs of musculoskeletal manipulations for adults (aged ≥18 years) with neck pain will be considered eligible for inclusion. A pairwise meta-analysis and network meta-analysis will be performed, and pooled risk ratios, standardised mean differences and 95% CIs will be determined.
ETHICS AND DISSEMINATION: Ethics approval is not required as this study is a literature review. The results of this review will be published in peer-reviewed journals or disseminated at conferences.
PROSPERO REGISTRATION NUMBER: CRD42023420775.
The invention belongs to the field of a biological medicine and relates to application of a human gene MK5 for screening and preparing a drug for inhibiting growth of liver cancer cell. The liver cancer is one of common tumors around the world at present. The quantity of patients who die of the liver cancer every year ranks the third place of the quantity of the patients who die of tumors. The MK5 disclosed by the invention has an effect of promoting a liver cancer cell to resist adriamycin-induced apoptosis, and can developed as a novel drug target for inhibiting growth of the liver cancer cell. SiRNA of the MK5 has an effect of promoting adriamycin-induced apoptosis of liver cancer cell, can be used together with adriamycin to inhibit growth and multiplication of the liver cancer cell or can be combined with the adriamycin to be used as a drug for promoting apoptosis of the liver cancer cell. The MK5 disclosed by the invention and an antagonist thereof can be used for preparing the drug for inhibiting growth of the liver cancer cell; a novel way and means are provided for treatment and detection of the liver cancer.