anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Atrial fibrillation (AF) is a risk factor for cerebral ischemia. Identifying the presence of AF, especially in paroxysmal cases, may take time and lacks clear support in the literature regarding the optimal investigative approach; in resource-limited settings, identifying a higher-risk group for AF can assist in planning further investigation.
OBJECTIVE: To develop a scoring tool to predict the risk of incident AF in the poststroke follow-up.
METHODS: A retrospective longitudinal study with data collected from electronic medical records of patients hospitalized and followed up for cerebral ischemia from 2014 to 2021 at a tertiary stroke center. Demographic, clinical, laboratory, electrocardiogram, and echocardiogram data, as well as neuroimaging data, were collected. Stepwise logistic regression was employed to identify associated variables. A score with integer numbers was created based on beta coefficients. Calibration and validation were performed to evaluate accuracy.
RESULTS: We included 872 patients in the final analysis. The score was created with left atrial diameter ≥ 42 mm (2 points), age ≥ 70 years (1 point), presence of septal aneurysm (2 points), and score ≥ 6 points at admission on the National Institutes of Health Stroke Scale (NIHSS; 1 point). The score ranges from 0 to 6. Patients with a score ≥ 2 points had a fivefold increased risk of having AF detected in the follow-up. The area under the curve (AUC) was of 0.77 (0.72-0.85).
CONCLUSION: We were able structure an accurate risk score tool for incident AF, which could be validated in multicenter samples in future studies.
PURPOSE: A composition for preventing or treating immune diseases or inflammatory diseases is provided to prevent or treat atopic dermatitis with excellent treatment effect using stem cells. CONSTITUTION: A composition for preventing or treating immune diseases or inflammatory diseases contains stem cells as an active ingredient. The stem cells express ZNF281 and NOD2. The stem cells are human adult stem cells, human pluripotent stem cells, induced pluripotent stem cells, or animal embryonic stem cells or adult stem cells. A method for preparing the composition comprises the steps of: isolating the stem cells; and culturing the isolated stem cells. [Reference numerals] (AA) Gross lesion (Day 30); (BB) Gross lesion (Time course)
Non-fibrous cellulosic materials or cellulose derivatives, e.g cellulose acetate are impregnated with an essential oil and "diacetone" (i.e. acetylacetone or diacetone alcohol) with or without a plasticizer, e.g. diethyl phthalate, the diacetone being employed to prevent the formation of a bloom on the surface of the completed article.  The product may be formed into sheets, films &c. and may be shaped, e.g. by pouring a solution of the material on to a matrix plate to produce an article of desired shape such as a leaf.ALSO:Non-fibrous cellulosic materials or cellulose derivatives, e.g cellulose acetate are impregnated with an essential oil and "diacetone" (i.e. acetyl-acetone or diacetone alcohol) with or without a plasticizer, e.g. diethyl phthalate, the diacetone being employed for the purpose of preventing the formation of a bloom on the surface of the completed article.  The product may be formed into sheets, films, &c. and may be shaped, e.g. by pouring a solution of the cellulosic material and the other ingredients on to a matrix plate to produce an article of desired shape such as a leaf.
INTRODUCTION: Metabolic and bariatric surgery (MBS) has experienced considerable growth, addressing the challenges of obesity and its complications. The lack of a comprehensive bibliometric analysis in Latin America motivates this study, highlighting the need to understand the evolution of research in this area and its impact on clinical decision-making and health policies.
METHODOLOGY: A cross-sectional bibliometric study was carried out using the Scopus database. A structured search strategy was designed to identify articles related to bariatric surgery with authors affiliated with Latin American countries. Inclusion and exclusion criteria were applied, followed by a descriptive and bibliometric analysis of the scientific production found.
RESULTS: A total of 3553 documents published between 1991 and 2024 were included. There was an annual growth of 11%, with an average age of documents of 7.5 years. A concentration was observed in some countries, notably Brazil, Mexico, and Chile. Although scientific output increased, the average number of citations per article showed a downward trend since 2003.
DISCUSSION: Despite the growth in scientific production, the quality and relevance of research is questioned, especially given the decrease in the impact received. It highlights the lack of meaningful regional collaboration, which could limit the sharing of knowledge and resources. Questions are raised about gaps in research capacity and the economic and development implications are discussed.
CONCLUSIONS: This study provides valuable information to strengthen future research in bariatric surgery in Latin America. It highlights the importance of promoting regional and international collaboration and improving research training in countries with less participation. Clinical intervention strategies can benefit from better understanding research trends and adopting evidence-based practices in a more informed manner.
Angiogenesis, the process of formation of new blood vessels from pre-existing vasculature, is essential for tumor growth and metastasis. Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF) signaling is a powerful tool to combat tumor growth; however, anti-tumor angiogenesis therapy has shown limited efficacy, with survival benefits ranging from only a few weeks to months. Compensation by upregulation of complementary growth factors and switches to different modes of vascularization have made these types of therapies less effective. Recent evidence suggests that targeting specific players in endothelial metabolism is a valuable therapeutic strategy against tumor angiogenesis. Although it is clear that metabolism can modulate the translational machinery, the reciprocal relationship between metabolism and mRNA translational control during tumor angiogenesis is not fully understood. In this review, we explore emerging examples of how endothelial cell metabolism affects mRNA translation during the formation of blood vessels. A deeper comprehension of these mechanisms could lead to the development of innovative therapeutic strategies for both physiological and pathological angiogenesis.
FIELD: hygiene.SUBSTANCE: group of inventions concerns a composition for oral hygiene and methods for its application. Disclosed composition comprises an effective amount of aluminum chlorohydrate, suspended in a carrier, to prevent or reduce hypersensitivity of teeth, where the aluminum chlorohydrate is present in amount of 0.01 wt. % to 20 wt. % of the total weight of the composition and is made using a buffer selected from glycine and betaine, and demonstrates a SEC chromatogram having the intensity ratio SEC Peak 4 to Peak 3, equal to at least 7, and Peak intensity 4, which is greater than Peak 5 intensity. Carrier is a hydrophobic carrier containing triglyceride C-Cfatty acids and is present in the composition in amount of 5 wt. % to 99 wt. % of the total weight of the composition. Composition contains maximum amount of water 3 % by weight. Intensities of said peaks are determined using a SEC chromatogram using the following parameters: analytical pump and Waterscontroller, 77251 Rheodynedispenser, Protein-Pakcolumn 125 (Waters), Refractometer Waters 2414, 5.56 mmol of mobile phase nitric acid, 0.50 ml/min flow rate, 2.0 microliter of sample volume and data analysis using WaterEmpower software (Waters Corporation, Milford, Mass). Also presented is a method for prevention, reduction or reduction of dental hypersensitivity and a method for closing dental tubules involving administering said composition into the oral cavity of a subject.EFFECT: using the group of inventions provides effective occlusion of the dental canal and thereby preventing or reducing the hypersensitivity of the teeth.15 cl, 1 tbl, 2 ex
A single-chain antibody and an application thereof. The single-chain antibody comprises: an IFNγ secretory signal peptide, an antibody variable region, an IgG1 hinge fragment, and an IgG1 CH2CH3 region connected in that order. An amino acid sequence of the IFNγ secretory signal peptide is shown in SEQ ID NO:1, with a base sequence as shown in SEQ ID NO:2. An amino acid sequence of the IgG1 hinge fragment is shown in SEQ ID NO:3, with a base sequence as shown in SEQ ID NO:4. The single-chain antibody is used mainly in medical and biotechnology fields, and the main uses thereof are: 1, as a coupling tracer for tumor imaging during surgery; 2, as a targeting drug for a targeting treatment; 3, as a neutralizing antibody to a bound target thereof, inhibiting a function of the bound target; and 4, for detecting the expression of an antigen recognized by the variable region. The present invention preserves the functions and stability of an antibody, simplifies a manufacturing process and an antibody structure, and improves a performance of an antibody.
The invention provides a method for assessing risk of a reurodegenerative disease or disorder in a subject. The method comprises comparing a level of anti-amyloid peptide antibody in a biological sample from a subject to a normal level, wherein a lower level in the biological sample from the subject indicates the presence of the disease or disorder. In a specific embodiment, the disease or disorder is Alzheimer's Disease (AD); in a further specific embodiment, the amyloid peptide is β-amyloid-42 (Aβ42). In addition, the discovery that certain neurodegenerative diseases or disorders are associated with a deficiency of anti-amyloid antibodies provides a method of treating of treating such a disease or disorder in a subject. This method comprises administering a therapeutically effective amount of a human anti-amyloid peptide antibody to a subject believed to suffer from the immune deficiency or disorder. For example, the disease or disorder can be Alzheimer's Disease (AD). In such an embodiment, the amyloid peptide can be β-amyloid-42 (Aβ42).
Ratcheted grasper is inserted through the lateral 5-mm port to retract the gallbladder fundus in cephalad fashion. An atraumatic grasper is inserted through the middle 5-mm port to retract the gallbladder infundibulum laterally, exposing the anteromedial aspect of the triangle of Calot.
The present invention provides a composite powder which displays an adsorption position for attracting or adsorbing a specific enzyme, and an action position for inhibiting or activating the specific enzyme. The zeta potential of the adsorption position of this powder is negative at pH 7.5, so it can attract or adsorb the specific enzyme having a positive zeta potential. Preferably, the zeta potential of the adsorption position is less than -10 mV at pH 7.5. Preferably, the specific enzyme is plasminogen activator, and said action position possessing the plasminogen activator inhibition activity. This powder is useful as rough skin improving agent and sensitive skin ameliorating agent. The rough skin improving agent or sensitive skin ameliorating agent of the present invention contain one kind or more of this powder.
Ageing-associated loss of muscle mass and strength is a major cause of physical frailty, disability, morbidity and dependency in the elderly. This is associated with increased falls, fractures, loss of mobility, restricted activities of daily living and increased utilisation of healthcare resources. It is well known that serum testosterone levels fall with advancing age and this may be an important cause for muscle wasting and weakness (sarcopenia). Testosterone replacement increases muscle mass and improves muscle strength in young hypogonadal men. In relatively healthy elderly men, some short-term studies have also shown that testosterone can improve muscle strength. The potential beneficial effects of testosterone supplementation on muscle strength and functional capacity of frail elderly men has so far not been studies and forms the basis of this research. We hypothesise that testosterone supplementation is an effective, safe and economic anabolic intervention in frail elderly men with low circulating testosterone.
A method of creating medical documentation uses selection of images representing synonyms for complex medical concepts. The images can be of two types, one corresponding to a parameter or Key in a Key/Value pair and the other corresponding to possible values of the selected parameter or Key. The user first selects an image or portion thereof corresponding to the parameter they wish to record observations, such as the heart or a valve of the heart. A set of images representing possible values of the parameter is then displayed e.g., images representing possible murmurs the selected valve may have. The user selects the image representing the value corresponding to the observation of the patient. A document is created by recording either the Key/Value image pairs or, alternative, text representing the synonyms for the images. Other methods of recording the document are possible, such as instantiating a set of class objects.
PROBLEM TO BE SOLVED: To obtain the above agent capable of effectively preventing both acute and chronic cardiac infarction, having highly reliable therapeutic effect as a first aid in a stroke, and harmless to human body, containing, as active ingredient, a polypeptide having human adult T-cell leukemia-derived factor activity. SOLUTION: This preventive/therapeutic agent contains, as active ingredient, a polypeptide having human adult T-cell leukemia-derived factor activity (e.g., having an amino acid sequence of the formula, having another sequence produced by adding a methionine residue to the N-terminal of the 1st valine in the amino acid sequence of the formula). This polypeptide is obtained, for example, by the following process: a human-derived cell strain such as ATL-2 cell is cultured, and from the resultant culture fluid or cell liquid extract, the aimed polypeptide is purified through salting-out or chromatography such as gel filtration chromatography. It is preferable that this agent be made into pharmaceutical preparations for intravenous injection and its dose, for adult, be 0.0001-10 (esp. 0.001-1.0)mg/kg b.w. a day.
The research question we are exploring is whether the conventional approach is better in terms of successful treatment, compliance with treatment, and quality of life. There will be 2 arms to the study. Subject will be randomly assigned to either one of the following two treatment options: 1) the conventional investigation and nasal CPAP treatment pathway comprising 2 overnight sleep studies, one for diagnosis and one for determining the required level of nasal CPAP treatment 2) experimental pathway that uses a simplified home study (overnight oximetry), together with a machine that automatically adjusts the nasal CPAP pressure to the required amount, and a careful follow-up during the first 2 weeks of treatment.

Procedures: The study protocol will require the subject to complete the following procedures which are part of routine clinical practice: History and Physical Examination by a physician, Home Oximetry (This simple test involves wearing an oxygen probe gently wrapped around subject's finger during a night's sleep to continuously measure the amount of oxygen in blood and detect obstructions of subject's breathing. The probe is easily applied by the subject and requires no supervision), Spirometry (simple non-invasive breathing test), Standardized Sleepiness Questionnaires, Orientation and Education regarding nasal CPAP therapy, and compliance monitoring, Overnight polysomnography (This is the procedure that requires subject to spend a night in the sleep laboratory with a variety of painless and non-invasive monitoring devices attached to the body. The purpose is to obtain detailed information about subject's sleep quality, breathing, heart function, and body movements during sleep. Subject will be continuously monitored by a trained technologist during this procedure.). The following procedures are not routine and subject may be required to complete some or all of them depending on which pathway assigned to. Follow-up visits to the Clinic on Days 7 and 14 of nasal CPAP treatment for adjustments of nasal CPAP pressure as required (this could also be done at home), Repeat Home Oximetry as required, Quality of Life Questionnaire.
Participants will be asked to go to bed normally but wake up earlier, such that normal sleep duration is restricted by 60%. For example, if someone normally sleeps for 8 hours by falling asleep at 11 pm and waking up at 7 am, they will be asked to fall asleep normally (11 pm) and sleep for 3.2 hours, which results in a wake-up time of 2:12 am.
PURPOSE: An anti-wrinkle cosmetic composition is provided to be shrinked while moisture is evaporated, thereby the lotion including the composition moists the skin. CONSTITUTION: An anti-wrinkle cosmetic composition includes a polymer having water-absorption and swelling properties as an active ingredient. The anti-wrinkle cosmetic composition includes a first mineral having the water-absorption and swelling properties. The polymer is edible gums which are added to the food. The gums are seaweed polysaccharide, agar, alginic acid or carrageenan. The first mineral is montmorillonite based mineral, montmorillonite, bentonite or acid clay, and the average granularity is 20-30 nano meters. The cosmetic composition additionally includes Kaolinite, kaolin based mineral of dickite or halloysite, and mica mineral of illite or glauconite.
PROBLEM TO BE SOLVED: To obtain the subject accelerator capable of recovering reduced skin barrier function remarkably in a short time by containing phytosterol. SOLUTION: This accelertor for recovering skin barrier function contains phytosterol. Phytosterol is a mixture of plant originated sterols and mainly contains β-sitosterol, campesterol, stigmasterol, etc. To accelerate recovering of skin barrier function means to have an accelerating effect in a TEWL recovery factor with a clearly significant difference when TEWL values at every measuring time are compared with the value without any treatment by bringing the TEWL value after 1 hour of tape stripping of the skin to be 0% and the value before the tape stripping to be 100%. The accelerator can be added to cosmetics, medicines and quasi-drug baes. The amount to be added is preferably 0.1-20 wt.% in the whole amount of the aforesaid cosmetic and the like.
Dysorgasmia in women is an infrequent reason for consulting a clinician. In this article, the authors describe the case of a woman with right-sided pelvic pain immediately after orgasm. Dysorgasmia is likely to negatively impact sexual health but is rarely discussed in medical literature. Furthermore, assessment and treatment guidelines for clinicians are currently lacking. Therefore, the authors conducted a literature review and created a preliminary assessment guide, considering both medical and gray literature. A brief flowchart was developed which can facilitate the assessment of dysorgasmia in women for clinicians and improve the quality of care for patients. Further research on the etiology and pathophysiology of dysorgasmia in women is warranted, as is a more proactive attitude of clinicians to discuss sexual health. More guidance on diagnosis and treatment is needed.
Use of metalloprotease inhibitors (I) such as polyacrylate for the preparation of an agent to treat chronic wound. Independent claims are included for: (1) a metalloprotease inhibitor such as polyacrylate; and (2) wound pad comprising the metalloprotease inhibitor. ACTIVITY : Vulnerary. MECHANISM OF ACTION : Matrix metalloprotease inhibitor. The matrix metalloprotease inhibiting activity of (I) to treat wound was tested in-patient. The result showed that (I) exhibited 100% enzyme activity against the wound.
IV patient-controlled analgesia (PCA) tramadol Tramadol infusion (PCA): 400 mg tramadol, IV 4 mg/mL tramadol solution into 100 mL normal saline; PCA settings: 0.3 mg/kg bolus, 10 mg Demand dose and 20 min lock out interval, six-hour limit infusion to attain 100 mg. Maximum daily dose was set at 400 mg.
BACKGROUND: Epinephrine is administered to increase coronary perfusion pressure during advanced life support and promote short-term survival. Recent cardiopulmonary resuscitation (CPR) guidelines recommend an epinephrine dosing interval of 3 to 5 minutes during resuscitation; however, scientific evidence supporting this recommendation is lacking. Therefore, we aimed to investigate the hemodynamic effects of repeated epinephrine doses during CPR by monitoring augmented blood pressure after its administration in a swine model of cardiac arrest.
METHODS AND RESULTS: A secondary analysis of data from a published study was performed using a swine cardiac arrest model. The epinephrine dose was fixed at 1 mg, and the first dose of epinephrine was administered after no-flow and low-flow times of 2 minutes and 8 minutes, respectively, and subsequently administered every 4 minutes. Four cycles of dosing intervals were defined because a previous study was terminated 26 minutes after the induction of ventricular fibrillation. Augmented blood pressures and corresponding timelines were determined. Augmented blood pressure trends following cycles and the epinephrine effect duration were also monitored. Among the 140 CPR cycles, the augmented blood pressure after epinephrine administration was the highest during the first cycle of CPR and decreased gradually with further cycle repetitions. The epinephrine effect duration did not differ between repeated cycles. The maximum blood pressure was achieved 78 to 97 seconds after epinephrine administration.
CONCLUSIONS: Hemodynamic augmentation with repeated epinephrine administration during CPR decreased with cycle progression. Further studies are required to develop an epinephrine administration strategy to maintain its hemodynamic effects during prolonged resuscitation.
OBJECTIVES: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP.
MATERIALS AND METHODS: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP.
RESULTS: Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP.
CONCLUSIONS: Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.