anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: This study was to investigate the correlation between oxidative balance score (OBS) and the prevalence of kidney stones in the general adult population.
MATERIALS AND METHODS: We conducted an analysis using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) project, including 17,988 participants. The OBS was computed based on previous research, combining 16 dietary factors and 4 lifestyle factors. Multiple logistic regressions and restricted cubic spline (RCS) regressions were utilized to explore the associations between OBS and kidney stone prevalence.
RESULTS: Our analysis included 1,622 adults with kidney stones and 16,366 adults without kidney stones. The average age of participants was 46.86 ± 0.27 years, with 50.72% being male. The median OBS was 22.00 (17.00, 27.00). After adjusting for all covariates, each one-unit increase in OBS was associated with a 3% decrease in kidney stone prevalence (odds ratio [OR] = 0.97 [0.96-0.98], P < 0.001). Moreover, compared to the first quartile, the fourth quartile of OBS (OR = 0.65 [0.50-0.84], P = 0.001) exhibited a negative association with kidney stone prevalence after adjusting for multiple variables. Furthermore, we observed a non-linear negative relationship between OBS and kidney stone prevalence, with inflection points at 18.2 (P for nonlinearity = 0.048). Stratified analysis did not identify any variables significantly affecting the results.
CONCLUSION: Our findings indicate that a higher OBS is associated with a decreased prevalence of kidney stones in the general adult population.
Echinococcus granulosus is a zoonotic parasite infects many livestock species, especially cattle, sheep, goat and buffalo, causing cystic echinococcosis. The aim of this study was to demonstrate the presence of the parasite and parasitic tissue damage histopathologically and to determine the role of oxidative stress in the tissue damage through the immunohistochemical detection of the oxidative damage-marker malondialdehyde (MDA) and the antioxidant response-marker superoxide dismutase (SOD). The material of the study consisted of 20 liver samples with Echinococcus cysts and 10 E.granulosus- negative healthy liver samples obtained from different cattle at various times from slaughterhouses in Kırıkkale province, Turkey. Histopathologically, Echinococcus cysts of various sizes were observed along with the surrounding fibrous connective tissue. Giant cells, mononuclear cells, and eosinophilic leukocytes were found between the fibrous connective tissue and the cyst. In the parenchymal tissue distant from the cyst, inflammatory changes were observed, including vacuolation and necrosis in hepatocytes, congestion and dilation sinusoidal capillaries. Immunohistochemically, MDA immunopositivity was observed in both hepatocytes surrounding the cyst and areas distant from the cyst, while SOD immunopositivity was mainly detected in fibrous connective tissue and hepatocytes surrounding the Echinococcus cysts. A significant increase in MDA immunoreactivity was observed in E.granulosus s.l.-infected livers. Although no statistically significant change was observed in SOD immunopositivity in the liver tissues with cystic echinococcosis, regional variations were noted. Germinal layer (GL) of Echinococcus cyst showed immunopositive staining for MDA, while laminated layer (LL) exhibited immunonegative staining. To the authors' best understanding, this study represents a pioneering effort in showcasing and evaluating the immunoreactivities of MDA and SOD within the liver tissue afflicted with Echinococcus cysts. Simultaneously, the examination extends to encompass tissue damage and the infiltration of inflammatory cells. This study highlights the role of oxidative stress in the pathogenesis of Cystic Echinococcosis (CE) and the need for further investigation of antioxidant defense mechanisms and their regional variations.
Severe obesity affects 4.7% of the U.S. population. A significant number of these individuals suffer from impaired glucose tolerance and type II diabetes due to insulin resistance (IR). Although it is generally accepted that the accumulation of intraabdominal (IA) fat increases the risk of developing IR, the mechanisms responsible for this phenomenon are not yet understood. In addition, the role of subcutaneous (SC) fat towards the etiology of IR - protective, inert or detrimental - is still under debate. This is because SC adipose tissue releases adipocytokines (IL-6, leptin, TNF-a) that have been demonstrated to impair insulin action. In individuals who are severely obese, hyperinsulinemia may induce an exaggerated production of adipocytokines from IA compared to SC fat stores. Our specific aims are: (1) to determine relative contribution of abdominal SC fat versus IA fat to systemic levels of IL-6, leptin and TNF-a in lean and in severely obese individuals; (2) to determine the effects of systemic adipocytokine concentrations on whole body as well as tissue sensitivity to insulin. Hypothesis: (a) In the context of severe obesity, IA fat produces increased quantities of IL-6, leptin and TNF-a compared to SC fat; (b) In severely obese patients undergoing weight loss, whole body and tissue IR can be predicted by changes in systemic adipocytokines. Methods: Adipose tissue content of IL-6, leptin and TNF-a will be determined by ELISA in biopsies obtained from IA and SC fat stores in lean and severely obese patients. Computer tomography-determined areas of IA and SC fat will be related to changes in systemic adipocytokines at baseline and 6-mo following weight loss therapy. Changes in systemic IL-6, leptin and TNF-a will be assessed from measurements made at baseline and following 6-mo weight loss. For this time period we will also determine changes in whole body (via IVGTT) and tissue sensitivity to insulin (via glucose uptake into muscle and fat). Relationships between systemic adipocytokines and IR will be assessed using uni- and multivariate correlation analysis. These novel studies will determine whether hypersecretion of adipocytokines by IA versus SC adipose tissue induces IR in patients with severe obesity.
A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device carried by a patient at least when the patient is in a non-clinical environment. The processing module extracts medically relevant data from the sensory data received from the sensor in the mobile device. The relevant data includes one or more features of interest in the sensory data. The analysis module derives one or more surrogate biomarkers from the relevant data. The surrogate biomarkers represent at least one of a state or a progression of a medical condition of the patient. The mobile device may be a mobile phone carried by the patient and the sensor may include at least one of an accelerometer or a gyroscope that generates the sensory data to represent movements of the patient.
Trastuzumab (Tras) was administered as an open-label, commercial product at an initial dose of 8 mg/kilograms (kg) over a 90-minute intravenous infusion, followed by 6 mg/kg over a 30- to 90-minute intravenous infusion once every 3 weeks. The dose could have been adjusted for toxicity management, per commercial labeling. The investigator could have interrupted, modified, or discontinued trastuzumab with medical monitor approval. Participants self-administered oral pemigatinib 13.5 mg QD on a 2-weeks-on therapy and 1-week-off therapy schedule. The treatment cycle consisted of: Days 1 through 14: pemigatinib QD; Days 15 through 21: treatment break. It was permissible to continue pemigatinib administration during the toxicity break of trastuzumab.
PURPOSE:To obtain the titled remedy having mild and slow activity and very little side effects, by using 9-chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-[1]benzopyrano [2,3-b]pyridine, etc. as active component. CONSTITUTION:The compound of formula useful as an antiallergic agent, its salt (e.g. Na salt, K salt, Ca salt, NH4 salt, etc.) and/or its hydrate is used as an active component to obtain the objective remedy for hypertension. The remedy is administered in the form of capsule, tablet, powder, granules, etc. The dose of the compound of formula is 120-720mg daily by oral administration as Na salt pentahydrate. The compound is also being used as an antiallergic agent and a remedy for bronchial asthma.
Of the 359 patients in clinical studies of SUBSYS in breakthrough cancer pain, 27% were 60 years of age and older, 17% were 65 years of age and older, and 3% were 75 years of age and older. No difference was noted in the safety profile of the group over 65 years of age as compared to younger patients in SUBSYS clinical trials.

Elderly patients have been shown to be more sensitive to the effects of fentanyl when administered intravenously, compared with the younger population. Therefore, monitor patients for respiratory depression and CNS effects when titrating SUBSYS in elderly patients.

Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid tolerant or when opioids were co-administered with other agents that depress respiration. Titrate the dosage of SUBSYS slowly in geriatric patients and monitor closely for signs of central nervous system and respiratory depression [ see Warnings and Precautions ( 5.1)] . 

Fentanyl is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
The SEIR (susceptible-exposed-infected-recovered) model has become a valuable tool for studying infectious disease dynamics and predicting the spread of diseases, particularly concerning the COVID pandemic. However, existing models often oversimplify population characteristics and fail to account for differences in disease sensitivity and social contact rates that can vary significantly among individuals. To address these limitations, we have developed a new multi-feature SEIR model that considers the heterogeneity of health conditions (disease sensitivity) and social activity levels (contact rates) among populations affected by infectious diseases. Our model has been validated using the data of the confirmed COVID cases in Allegheny County (Pennsylvania, USA) and Hamilton County (Ohio, USA). The results demonstrate that our model outperforms traditional SEIR models regarding predictive accuracy. In addition, we have used our multi-feature SEIR model to propose and evaluate different vaccine prioritization strategies tailored to the characteristics of heterogeneous populations. We have formulated optimization problems to determine effective vaccine distribution strategies. We have designed extensive numerical simulations to compare vaccine distribution strategies in different scenarios. Overall, our multi-feature SEIR model enhances the existing models and provides a more accurate picture of disease dynamics. It can help to inform public health interventions during pandemics/epidemics.
Active sessions will involve the placement of the anode over the scalp corresponding to the F3 (10-20 EEG system), and cathode over F4. Current intensity will be 2mA, and the stimulation will last for 20 minutes.
Sepsis is a systemic inflammatory response syndrome (SIRS) caused by infection, which may lead to multiple organ dysfunction in susceptible patient. The most frequently involved organs/systems include the lung, kidney and circulation system. It is well established that sepsis is a risk factor for acute lung injury. While overt pulmonary infiltrates can be well captured by human operators, subtle structural changes of the lung might be ignored. Since the advantage of chest computed tomography (CT) is its capability of providing fine structural changes in high spatial resolution, the study of chest CT by means of computer science may provide further insights into the underlying pathophysiology. The integration of chest CT into the study of sepsis is limited partly due to the lack of well-curated database. The study aims to establish a database comprising detailed clinical tabular data, as well as the raw chest CT images. The database is intended to support a wide array of research studies involving radiomics in sepsis patients, helping to reduce barriers to the reproducibility of clinical research.
<P>PROBLEM TO BE SOLVED: To obtain a therapeutic composition comprising carotenoids enclosed in liposomes or other lipid carrier particles.  <P>SOLUTION: This invention discloses a reduced-toxicity formulation of carotenoids, which is stable in an aqueous environment. The formulation includes the carotenoids, lipid carrier particles (such as liposomes), and an intercalation promoter agent (such as a triglyceride) capable of substantially uniformly distributing the carotenoids together with the lipid in the lipid carrier particles. The molar ratio of carotenoids to the lipid is greater than about 1:10. Also disclosed is a method for inhibiting the growth of cancer cells, which comprises administering to a living body a therapeutically effective amount of the composition described above.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Cosmetic and therapeutic use, with respect to pigmentation, of a polynucleotide fragment (A) comprising at least 18 consecutive nucleotides (nt) corresponding to at least part of human chromosome 9 between the markers D9S1677 and D9S1682. (A) contains 30-5000 nt. Independent claims are also included for the following: (1) method for diagnosing a predisposition to precocious canitis (whitening of the hair) by determining the alleles of markers present in the region between D9S1677 and D9S1682; (2) use of at least one of the markers D9S1677, D9S1776 and D9S1682 to determine genes implicated in progressive or sudden interruptions of pigmentation of skin and its appendages; and (3) kit comprising at least one (A) and at least one other polynucleotide fragment (B). ACTIVITY : Dermatological. No details of tests for dermatological activity are given. MECHANISM OF ACTION : Modification of the function and/or expression of genes, or their expression products, involved in pigmentation.
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression. Within the intestinal epithelium, miRNAs play a critical role in gut homeostasis, and aberrant miRNA expression has been implicated in various disorders associated with intestinal inflammation and barrier disruption. In this study, we sought to profile changes in intestinal epithelial cell miRNA expression after alcohol and burn injury and elucidate their impact on inflammation and barrier integrity. Using a mouse model of acute ethanol intoxication and burn injury, we found that small intestinal epithelial cell expression of miR-146a is significantly decreased 1 d following injury. Using in vitro studies, we show that reduced miR-146a promotes intestinal epithelial cell inflammation by promoting p38 MAPK signaling via increased levels of its target TRAF6 (TNFR-associated factor 6). Furthermore, we demonstrate that in vivo miR-146a overexpression significantly inhibits intestinal inflammation 1 d following combined injury and potentially supports intestinal barrier homeostasis. Overall, this study highlights the important impact that miRNA expression can have on intestinal homeostasis and the valuable potential of harnessing aberrant miRNA expression as a therapeutic target to control intestinal inflammation.
New oral rinse solutions and mouthwashes are provided. The oral rinse solutions comprise essential oil and alcohol, supplemented with hydrogen peroxide, and natural extracts. The essential oil and/or alcohol can be provided as part of a base composition. The most preferred base compositions are antiseptic mouthwashes containing the essential oil and/or alcohol. Alternatively, the ingredients can be individually added to the inventive composition. The oral rinse solutions provide antimicrobial activity while soothing oral inflammations and irritations, thus being useful for treating, alleviating, and promoting healing of a wide variety of oral ailments such as periodontal disease (gingivitis and periodontitis), plaque, oral inflammation, toothaches, oral ulcerations, dry socket, dentin hypersensitivity, and halitosis, as well as address aesthetic issues such as bad breath and tooth discoloration.
BACKGROUND: The aim of this study is to explore the prognostic value and immune signature of ITGB4 expression in lung adenocarcinoma (LUAD) brain metastasis.
METHODS: We comprehensively screened genes associated with LUAD brain metastasis by integrating datasets from the GEO database and TMT-based quantitative proteomics profiles. Univariable survival and Multivariate Cox analysis was used to compare several clinical characteristics with survival, and a risk model was constructed. The biological functions were explored via GO and KEGG analysis. Gene set enrichment analysis (GSEA) was performed using the TCGA dataset. In addition, we use TIMER to explore the collection of ITGB4 Expression and Immune Infiltration Level in LUAD. The ability of ITGB4 to regulate tumor metastasis was further assessed by migration, invasion assay and Western-blot in H1975-BrM4 cells.
RESULTS: We found that ITGB4 was the only gene with high clinical diagnostic and prognostic value in LUAD. Enrichment analysis indicated that ITGB4 is associated with brain metastasis, infiltration of immune cells, and the response to immunotherapy. ITGB4 expression can effectively predict the outcomes of patients with LUAD who are receiving anti-PD-1 therapy. ITGB4 knockdown inhibited the invasion, migration of H1975-BrM4 brain metastasis cells, as well as epithelial-mesenchymal transition (EMT) abilities. The heightened expression of ITGB4 protein was shown to promote EMT and enhance the metastatic potential. ITGB4 promotes the progression in H1975-BrM4 cells via MEK/ERK signaling pathway.
CONCLUSIONS: Our findings indicate that the expression of ITGB4 is linked to the occurrence of brain metastasis and infiltration of immune cells, suggesting that ITGB4 might be a clinical treatment target for LUAD.
Some retrospective analysises showed CTCs is considered to be valuable for diagnosis, staging, prognosis and follow-up in several types of cancers and some mRNA markers are helpful in differentiating patients with benign versus malignant thyroid disease. However, the lack of sensitivity and specificity of mRNA measurements restricted their clinical application. The aim of this study is to see if optimizing test method combined with ultrasound can get similar diagnostic performance. 200 patients with thyroid nodules (≤2cm) which need to undergo FNAB will be enrolled in four centers of northern China. Patients will simultaneously undergo CTCs tests and FNAB. And following treatments will be performed according to the previous standard. Allowed by the patients, the investigators will obtain 10ml peripheral blood samples from the participants to make a CTCs test before any FNAB. The primary end point is the pathologically confirmed benign versus malignant thyroid disease, which including surgical pathology and diagnostic results of FNAB.
This invention relates to treatment and detection of the diseases by Magnetic Resonance Imaging. Previously, there was no way to use MRI imaging to early detect and map the agent bind to hypoxia in tissue, blood brain barrier leakage or break down, tissue under glycolysis, brain activation in neurodegenerative diseases, aggressive cancer, senescent tissues, and T-cells senescent. Also, novel methods to treat neurodegenerative diseases, aging, senescent tissues and T-cells senescent. Embodiments of the present invention use novel treatment and imaging methods are disclosed for early detection and mapping of diseases by using MRI. The endogenous of the biological tissue and exogenous agents can be used to produce MRI contrast which rely on the endogenous proteins and exogenous protons, as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging and mapping for the early detection of hypoxia in tissue, blood brain barrier leakage or break down, tissue under glycolysis, brain activation in neurodegenerative diseases, aggressive cancer, senescent tissues, T-cells senescent, and other diseases by using endogenous and exogenous protons contrast by using MRI. Also, this invention relates to novel methods to treatment neurodegenerative disease, senescent cells and T-cells senescent.
BACKGROUND AND AIMS: CCN4/WISP-1 regulates various cell behaviours that contribute to atherosclerosis progression, including cell adhesion, migration, proliferation and survival. We therefore hypothesised that CCN4 regulates the development and progression of atherosclerotic plaques.
METHODS: We used a high fat fed ApoE-/- mouse model to study atherosclerotic plaque progression in the brachiocephalic artery and aortic root. In protocol 1, male ApoE-/- mice with established plaques were given a CCN4 helper-dependent adenovirus to see the effect of treatment with CCN4, while in protocol 2 male CCN4-/-ApoE-/- were compared to CCN4+/+ApoE-/- mice to assess the effect of CCN4 deletion on plaque progression.
RESULTS: CCN4 overexpression resulted in reduced occlusion of the brachiocephalic artery with less apoptosis, fewer macrophages, and attenuated lipid core size. The amount of plaque found on the aortic root was also reduced. CCN4 deficiency resulted in increased apoptosis and occlusion of the brachiocephalic artery as well as increased plaque in the aortic root. Additionally, in vitro cells from CCN4-/-ApoE-/- mice had higher apoptotic levels. CCN4 deficiency did not significantly affect blood cholesterol levels or circulating myeloid cell populations.
CONCLUSIONS: We conclude that in an atherosclerosis model the most important action of CCN4 is the effect on cell apoptosis. CCN4 provides pro-survival signals and leads to reduced cell death, lower macrophage number, smaller lipid core size and reduced atherosclerotic plaque burden. As such, the pro-survival effect of CCN4 is worthy of further investigation, in a bid to find a therapeutic for atherosclerosis.
PURPOSE:To provide the subject new compound K-18 or its base adduct salt exhibiting an inhibitory effect on calcium overload, an active oxygen-removing effect and an inhibitory effect on generation of a lipoperoxide. CONSTITUTION:The compound K-18 represented by the formula or its base adduct salt. The compound K-18 of the formula can be produce by aerobically culturing a K-18-producing cell strain [Bikoken stipulation No. 3741 (FERM- BP-3741)] belonging to Hyphomycetes, plexogenic Fungi Imperfecti in a suitable culture medium and collecting the above-mentioned compound from the cultured material. The above-mentioned new compound is useful as a medicine for preventing or improving various kinds of diseases or various kinds of symptoms such as inflammation or edema caused, e.g. by disturbance of circulation in the brain, the heart or the periphery.
PROBLEM TO BE SOLVED: To obtain an antimocroalgal agent excellent in new kinds of bioactivity such as antimicrobial activity for fish diseases, antimicroalgal activity and antiallergic activity by using a specific seven-membered heterocyclic compound bearing a sulfur atom as the active ingredient. SOLUTION: This antimicroalgal agent uses thiotropocin obtained by use of a microorganism belonging to the genus Caulobacter and having the ability to produce thiotropocin as the active ingredient. The microorganism is represented by the strain of Caulobacter sp. PK-654 (National Institute of Bioscience and Human-Technology, reference No. FERM BP-5080). The concentration of the active ingredient is suitably 0.01-10wt.% in emulsions, wettable powders or oils and 0.1-10wt.% in granule or dust.