anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subjects in this arm will receive sitagliptin 100 mg/d for one week as well as valsartan 160 mg/d for one week. After this subjects will report for study day #1. During the study day, subjects will be given intra-arterial neuropeptide Y. A four week washout of medication will occur after the study day. Subjects will then receive placebo/d and valsartan 160 mg/d for one week followed by study day #2.
Elderly 70 year old ladies who had been to an outpatient X-ray investigation were invited to participate in this study. They were all healthy without any signs of osteoporosis, or fractures.They were stimulated to participate by having done bone density measurements free. Patients who had used biphosphonates, oestrogens, glucocorticoids , diuretics, immunomodulating agents, or prolonged use of heparin were excluded.

Patients with possible secondary osteoporosis due to primary hyperthyroidism or chronic lung disease were also excluded. The participants were randomized into placebo or Mg-treatment groups. They were seen by the dietician, and blood and urine samples were taken at day 0, 7 and 28 at the same time these days. Medicine was prepacked for intake twice daily. They received medicine for 30 days and should only take for 28 days. The number of tablets which should be left was controlled the last day. The participants were informed about the results of the bone density measurements taken the first and the last day. All the patient contacts were undertaken by the same dietician.
The invention discloses a method for removing chronic nephrotic toxin by exosome targeting, which remarkably optimizes the drug effect when the compound GW-028 is combined with exosome. The exosomes are nano vesicles secreted by cells, and can carry and transfer various bioactive molecules to other cells, so that intercellular communication is realized. In this combination, the exosomes encapsulate GW-028, safely and efficiently transporting it to target cells, such as damaged kidney cells. After the exosomes are fused with the target cells, GW-028 releases and exerts its antioxidant and anti-inflammatory effects, reducing oxidative stress and inflammatory injury. Meanwhile, the exosomes release bioactive molecules such as mirnas and proteins, further promoting cell repair and regeneration. Therefore, the synergistic effect of the functional group characteristics of GW-028 and exosomes not only enhances the potential of treating chronic kidney disease, but also provides a new direction for clinical application and treatment strategies.
Single treatment (24000 µg by 30 intramuscular injections). A total of 6 participants will receive hMaxi-K, and 3 will receive placebo.
Patients at St. Olavs hospital who suffer cardiac arrest and pulseless electrical activity (PEA) as primary rhythm during 2018-2021. 120 episodes from St. Olavs hospital were collected previously (2010-2013). In addition 200 cases will be available from the hospital of The University of Pennsylvania, Philadelphia, USA.
NEW MATERIAL:A 4-diphenyl-1-( 4-substituted ) arylmethylazetidin-2-one of formula I (Y is halogen, 1-4C alkyl or 1-4C alkoxyl). EXAMPLE:3,4-Diphenyl-1-(4-methoxyphenyl)methylazetidin-2-one. USE:Useful as an anti-inflammatory agent, and used as an antipyretic, analgesic, antiphlogistic, antiallergic and immunological regulating agents, etc. PREPARATION:For example, 2,3-diphenylcyclopropenone is reacted with a 4-substituted benzylamine of formula II in an inert organic solvent, e.g. benzene, at room temperature or a lower temperature than room temperature to give the aimed compound of formula I . As an alternative method, a 1,3-dihalo-1,3-diphenylpropanone-2 is reacted with a 4-substituted benzylamine of formula IIIpreferably in the presence of an acid accetor agent for the formed hydrogen halide to afford the aimed compound of formula I .
Patients receive amifostine SC 30-60 minutes prior to each dose of IMRT. Patients also undergo SNT and LWRT as in arm IB.
Up to 80 individuals with diabetes or prediabetes with a history of food insecurity enrolled in a 6 month program offering free bimonthly fresh food boxes, nutrition education, and individualized support. Each enrolled individual will serve as their own control. The study will evaluate pre and post program changes in reported self-obtained home glucose levels, food security, and dietary intake.
Bacterial infections already pose a significant threat to skin wounds, especially in diabetic patients who have difficulty healing wounds. However, wound or bacterial infections are known to produce excess reactive oxygen species (ROS), and hypoxia may further hinder wound healing and the development of chronic wounds. In this study, a multifunctional hydrogel for ROS scavenging and bacterial inhibition was developed by cross-linking polyvinyl alcohol (PVA) and sodium alginate (SA) with graphene oxide (GO) loaded with silver-platinum hybrid nanoparticles (GO@Ag-Pt). The PVA/SA hydrogel loaded with GO@Ag-Pt exhibited the ability to scavenge different types of ROS, generate O2, and kill a broad spectrum of bacteria in vitro. The silver-platinum hybrid nanoparticles significantly increased the antibacterial ability against Escherichia coli and Staphylococcus aureus compared with silver nanoparticles (AgNps). GO@Ag-Pt loaded hydrogel was effective in treating infections caused by S.aureus, thereby significantly promoting wound healing during the inflammatory phase. Hydrogel therapy significantly reduced the level of ROS and alleviated inflammation levels. Notably, our ROS-scavenging, antibacterial hydrogels can be used to effectively treat various types of wounds, including difficult-to-heal diabetic wounds with bacterial infections. Thus, this study proposes an effective strategy for various chronic wound healing based on ROS clearance and bacteriostatic hydrogels.
PURPOSE: The aim of this study was to evaluate the safety, efficacy, and predictability of lenticule intrastromal keratoplasty (LIKE) for the correction of iatrogenic high hyperopia.
METHODS: Three patients (4 eyes) were referred to our department because of overcorrection of myopia induced by femtosecond laser-assisted in situ keratomileusis. All eyes exhibited hyperopia (between +4.00 and +8.00 D) and thin corneas ranging from 307 to 378 μm. Because of the regression of the use of laser ablation to correct high hyperopia and thin corneas, we initially adopted LIKE to correct iatrogenic high hyperopia in all 4 eyes. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, corneal topography, and anterior segment optical coherence tomography findings were recorded during each follow-up evaluation.
RESULTS: No postoperative complications, such as interface haze and opacification, were observed in the 4 eyes during each follow-up evaluation, with an average follow-up of 9.50 months. All eyes had significantly improved UDVA postoperatively. A total of 3 eyes achieved an UDVA of 20/25 or better while the other 1 eye had an UDVA of 20/40 postoperatively. In addition, 2 of the 4 eyes had a postoperative UDVA equal to or better than preoperative CDVA. No eyes lost any CDVA lines. All 4 eyes were within ±0.50 D of the spherical power (intended target of 0). The central corneal thickness and curvature of the anterior corneal surface in all 4 eyes increased postoperatively. Anterior segment optical coherence tomography revealed that the lenticule was transparent, with no wrinkles or offsets, during each follow-up evaluation.
CONCLUSIONS: LIKE for the correction of iatrogenic hyperopia has good efficacy and safety. Although an extremely thin cornea after overcorrection may not be suitable for hyperopic laser enhancement, LIKE is a good choice because of its good predictability and ability to restore the normal corneal structure.
PROBLEM TO BE SOLVED: To obtain a water in oil type low viscosity cosmetic or dermatologic preparation having a very low viscosity capable of spraying by making the cosmetic include an oil phase including a hydrophobic inorganic fine pigment, a water phase, a thickener and a surfactant. SOLUTION: This cosmetic or dermatologic preparation includes (A) an oil phase (e.g. polydecene, cyclomethicone or the like) including a hydrophobic inorganic fine pigment (e.g. titanium dioxide or the like), (B) a water phase, and (C) (i) a thickener preferably selected from a polymer of acrylic acid (e.g. Carbomer (R), Carbopol (R) of formula I or the like), an acrylate/alkyl acrylate copolymer of formula II (R' is a long chain alkyl; x, y are each a calculated amount of the comonomer), a 10-30C alkylacrylate/acrylate copolymer and a xanthene rubber, and (ii) 0.5 wt.% or less of a surfactant (e.g. stearic acid, stearate, isostearic acid or the like).
When the mother is not self-confident; They cannot fulfill their motherhood role, have difficulty in establishing a relationship with their baby, and cannot raise their babies in a healthy way. It is easier for mothers who have the necessary knowledge and skills to care for the baby to adapt to this process. The educational support given in the transition to motherhood will affect the mother's self-confidence and readiness for motherhood, thus affecting the baby's health.

The research will be conducted on the online platform between November 2022 and November 2023. The population of the randomized controlled study was Istanbul Haseki Training and Research Hospital Sultan Gazi Haseki Campus, the pregnant women followed in the pregnant outpatient clinic, the sample was n: 45 pregnant women who attended the online training meeting the sample selection criteria, 45 pregnant women informed on the website, and 45 pregnant women in the control group, a total of 135 mothers. will form the candidate. Pregnant women who are willing to participate in the study will be assigned to the groups by simple randomization method. During the research, the CONSORT 2018 statement will be followed. Research data; Data Collection Form will be obtained by Pregnants' Readiness for Newborn Hygienic Care Scale, Karitane Parental Self-Confidence Scale, LACTH (Breastfeeding Success Assessment) Scale and Infant Follow-up Form.
The implantable cardioverter defibrillator (ICD) has been shown to be effective in preventing mortality in patients with ventricular tachyarrhythmia. However, the expanding indications of this therapy will have an impact on the follow-up policy. Currently, regular follow-up visits are scheduled every 3 months. In this context, the recently-introduced "remote monitoring" devices constitute a promising new technique, allowing to transmit information about the status of the device and ICD therapies, without direct contact between patients and physicians. This monitoring by "tele-follow-up" might reduce the cost of care by avoiding useless visits to the implantation centre.

The aim of our study is to assess the cost-benefit ratio of "tele-follow-up" assisted care as compared with the conventional ICD follow-up. Thanks to an open label, randomized, 2 arms study : one using a telephone follow up, the other a conventional follow-up.
CAMS-G is an group-based adaptation of the Collaborative Assessment and Management of Suicidality (CAMS) that has been developed to address perceived burdensomeness and thwarted belongingness, two drivers of suicide risk. Ongoing assessment and treatment planning are completed using the CAMS Suicide Status Form in the group modality, with involvement from group members and group facilitators. Driver-focused intervention strategies and group process also occur in the group based upon the unique needs of the group members. Groups are 90-minutes in length and occur on a weekly basis.
PURPOSE:To obtain a blood platelet antiagglutination agent containing benzylisoquinoline derivative including a novel compound or acid addition salt thereof as an active ingredient. CONSTITUTION:A blood platelet antiagglutination agent containing a compound expressed by formula I (R1 and R2 are H, methoxy or benzyloxy; R3 is H, OH or methoxy; R4 is H or methyl; R5 is benzyloxy or phenyl; R6 is H or methoxy R1 and R2 or R5 and R6 together may form methylenedioxy) or acid addition salt thereof, e.g. 6,7-methylenedioxy-1,2,3,4-tetrahydro-1(2-benzyloxy-3- methoxybenzyl)-isoquinoline, as an active ingredient. The above-mentioned pharmaceutical is effective in treating and preventing cerebral thrombosis, cardiac infarction, etc. In the case of oral administration, the agent is used in a dose within the range of 10-1,000mg/day, preferably 30-300mg/day expressed in terms of the active ingredient. The compound expressed by formula I (R4 is H) is obtained by reacting a compound expressed by formula II with phosphorus oxychloride and reducing the resultant reaction product.
Participants will be given a stationary exercise bike for home use. They will be instructed to use the exercise bike five times a week for thirty-minute sessions. The exercise intensity prescription will be based on the subject's VO2max determined on pre-test day. The exercise program will start at 60% of intensity per session, and then will be increased by steps of 5% intensity every 2 sessions until participants reach 30 minutes of training at 80% intensity. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be instructed to log each training session. Participants will record duration of exercise, perceived exertion, average heart rate, maximum heart rate, and distance.
Social dominance is a universal phenomenon among grouped animals that profoundly affects survival, health, and reproductive success by determining access to resources, and exerting a powerful influence on subsequent behavior. However, the understanding of pain and anxiety comorbidities in dominant or subordinate animals suffering from chronic pain is not well-defined. Here, we provide evidence that subordinate mice are more susceptible to pain-induced anxiety compared to dominant mice. We propose that the gut microbiota may play a mediating role in this mechanism. Our findings demonstrate that transplantation of fecal microbiota from subordinate mice with chronic inflammatory pain, but not dominant mice, into antibiotics-treated pseudo-germ-free mice significantly amplifies anxiety-like phenotypes, highlighting the critical involvement of gut microbiota in this behavioral response. Using chronic inflammatory pain model, we carried out 16S rRNA sequencing and untargeted metabolomic analyses to explore the relationship between microbiota and metabolites in a stable social hierarchy of mice. Interestingly, anxiety-like behaviors were directly associated with some microbial genera and metabolites, especially bile acid metabolism. Overall, we have demonstrated a close relationship between social status and anxiety susceptibility, highlighting the contributions of gut microbiota and the associated metabolites in the high-anxiety state of subordinate mice with chronic inflammatory pain.
BACKGROUND: Early diagnosis of acute gallstone pancreatitis severity (GSP) is challenging in clinical practice. We aimed to investigate the efficacy of CT features and radiomics for the early prediction of acute GSP severity.
METHODS: We retrospectively recruited GSP patients who underwent CT imaging within 48 h of admission from tertiary referral centre. Radiomics and CT features were extracted from CT scans. The clinical and CT features were selected by the random forest algorithm to develop the ML GSP model for the identification of severity of GSP (mild or severe), and its predictive efficacy was compared with radiomics model. The predictive performance was assessed by the area under operating characteristic curve. Calibration curve and decision curve analysis were performed to demonstrate the classification performance and clinical efficacy. Furthermore, we built a web-based open access GSP severity calculator. The study was registered with ClinicalTrials.gov (NCT05498961).
RESULTS: A total of 301 patients were enrolled. They were randomly assigned into the training (n = 210) and validation (n = 91) cohorts at a ratio of 7:3. The random forest algorithm identified the level of calcium ions, WBC count, urea level, combined cholecystitis, gallbladder wall thickening, gallstones, and hydrothorax as the seven predictive factors for severity of GSP. In the validation cohort, the areas under the curve for the radiomics model and ML GSP model were 0.841 (0.757-0.926) and 0.914 (0.851-0.978), respectively. The calibration plot shows that the ML GSP model has good consistency between the prediction probability and the observation probability. Decision curve analysis showed that the ML GSP model had high clinical utility.
CONCLUSIONS: We built the ML GSP model based on clinical and CT image features and distributed it as a free web-based calculator. Our results indicated that the ML GSP model is useful for predicting the severity of GSP.
This is a randomised, double-blind, placebo-controlled, parallel-group, multicentre, 24 week study to be conducted in approximately 300 patients at approximately 14 clinical sites in the UK, 6 sites in Australia, 5 sites in Germany, and 2 sites in Canada. Women will be randomised 1:1 to receive 300 mcg/day TTS or placebo for a 24 week period. Consistent with previous phase III studies, efficacy will be assessed over 24 weeks using the Sexual Activity Log (SAL), and at 12 and 24 weeks using the Profile of Female Sexual Function (PFSF) and Personal Distress Scale (PDS). Safety will be assessed over the entire 24 weeks. Hormone data (free and total testosterone, total estradiol, and sex hormone binding globulin) will be collected at Weeks -4 and 24. The total duration of treatment for each patient is 24 weeks.
Reproduction studies have been performed in rats and rabbits with exposures (based on Cmax) up to 399 and 183 times, respectively, of that seen at a clinical dosage of 1 mg/kg/day and have revealed no evidence of teratogenicity. The incidence in fetuses of a common skeletal variation, unossified or incomplete ossification of sternebra, was increased in rats at 399 times human exposure, while no effect was observed at 216 times human exposure. A slight post-implantation loss was noted at 216 times the human exposure with no effect noted at approximately 135 times the human exposure. An increase in early rat neonatal mortality (birth to 4 days of age) occurred at 399 times the human exposure, while survival of neonates was unaffected at approximately 135 times the human exposure. A study in rats showed that stavudine is transferred to the fetus through the placenta. The concentration in fetal tissue was approximately one-half the concentration in maternal plasma. Animal reproduction studies are not always predictive of human response. 

There are no adequate and well-controlled studies of stavudine in pregnant women. Stavudine should be used during pregnancy only if the potential benefit justifies the potential risk. 

Fatal lactic acidosis has been reported in pregnant women who received the combination of stavudine and didanosine with other antiretroviral agents. It is unclear if pregnancy augments the risk of lactic acidosis/hepatic steatosis syndrome reported in nonpregnant individuals receiving nucleoside analogues (see WARNINGS: Lactic Acidosis/Severe Hepatomegaly with Steatosis). The combination of stavudine and didanosine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs the potential risk. Healthcare providers caring for HIV-infected pregnant women receiving stavudine should be alert for early diagnosis of lactic acidosis/hepatic steatosis syndrome.
The doxycycline -which was so-far useful for the therapy of microbial infections-can be utilized as an auxiliary antineoplastic factor against osteosarcomas. The chemotherapy is unable to suppress all the osteosarcomatic cells. The presence of the gelatinase MMP-9 and the vascular endothelial growth factor -VEGF in the osteosarcomatic cells surviving from chemotherapy are statistically significant factors for the survival of patients suffering from osteosarcoma. The doxycycline proved to be a strong inhibitor of the gelatinases MMP and especially of the gelatinases MMP-2 and MMP-9. The inhibition of the MMP by doxycycline can suspend the positive relation between MMP-9 and VEGF. Its angiogenic action can circumvent the problem of resistance of the osteosarcomatic cells in chemotherapy and improve life expectation in patients suffering from osteosarcoma.
The invention relates to a sugar-free soothing composition. The composition has very good curative effects on coronary heart disease and angina, and is suitable for diabetics to take. Meanwhile, a composition prepared by adding resin of sweetgum and akebia fruit into the composition can be used for remarkably reducing the blood fat of patients. The composition and auxiliary materials are further prepared into capsules which are free from sugar. In order to improve the bioavailability of the capsules, the composition is prepared into micro-capsules together with a polymer, propylene glycol alginate and mannitol, and the micro-capsules are filled into capsule shells made from gum karaya, gelatin, propylene glycol and water. The prepared capsules have the beneficial effects of remarkable curative effect, quick response, long and stable release of medicaments, high medicinal stability and the like.
Inherited thrombocytopenias (ITs) encompass a group of rare disorders characterized by diminished platelet count. Recent advancements have unveiled various forms of IT, with inherited thrombocytopenia 2 (THC2) emerging as a prevalent subtype associated with germline variants in the critical 5' untranslated region of the ANKRD26 gene. This region is crucial in regulating the gene expression of ANKRD26, particularly in megakaryocytes. THC2 is an autosomal dominant disorder presenting as mild-to-moderate thrombocytopenia with minimal symptoms, with an increased risk of myeloproliferative malignancies. In our study of a family with suspected IT, three affected individuals harbored the c.-118C>T ANKRD26 variant, while four healthy members carried the c.-140C>G ANKRD26 variant. We performed a functional analysis by studying platelet-specific ANKRD26 gene expression levels using quantitative real-time polymerase-chain reaction. Functional analysis of the c.-118C>T variant showed a significant increase in ANKRD26 expression in affected individuals, supporting its pathogenicity. On the contrary, carriers of the c.-140C>G variant exhibited normal platelet counts and no significant elevation in the ANKRD26 expression, indicating the likely benign nature of this variant. Our findings provide evidence confirming the pathogenicity of the c.-118C>T ANKRD26 variant in THC2 and suggest the likely benign nature of the c.-140C>G variant.
The investigation will recruit male and female patients 18-80 years old and diagnosed with glaucoma or ocular hypertension requiring hypotensive ocular treatment. Up to 100 subjects will be enrolled in the study to ensure a minimum of 80 completing three IOP fluctuation monitoring sessions. Patients will be considered enrolled in the study upon signature of informed consent. A screening visit and three 26-hour IOP fluctuation monitoring sessions are planned for each patient. IOP monitoring sessions will be carried out in ambulatory mode at 4 week intervals (plus/minus 7 days). All subjects will be monitored during the same period of the day (± 1hr). The expected duration of participation for each patient is of 3.5 days over three to four months. Patients will be recruited over a 16-month period. The total expected study duration is 16 months.