anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Topiramate is a sulfamate-substituted monosaccharide. Topiramate capsules (sprinkle) are available as 15 mg or 25 mg sprinkle capsules for oral administration as whole capsules or opened and sprinkled onto soft food. 

Topiramate, USP is a white to off-white powder with a bitter taste. Topiramate is most soluble in alkaline solutions containing sodium hydroxide or sodium phosphate and having a pH of 9 to 10. It is freely soluble in acetone, chloroform, dimethylsulfoxide, and ethanol. The solubility in water is 9.8 mg/mL. Its saturated solution has a pH of 6.3. Topiramate has the molecular formula C12H21NO8S and a molecular weight of 339.37. Topiramate is designated chemically as 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate and has the following structural formula: 

Topiramate capsules (sprinkle) contain topiramate beads in a hard gelatin capsule. The inactive ingredients are carboxymethylcellulose calcium, FD&C Red No. 40, gelatin, hypromellose, lactose monohydrate, microcrystalline cellulose, polyethylene glycol, povidone, saccharin sodium, sodium lauryl sulfate, talc and titanium dioxide. 

The imprinting ink contains shellac, black iron oxide and traces of potassium hydroxide.
1488859 Composition for remineralising dental enamel PROCTER & GAMBLE CO 13 Nov 1974 [13 Nov 1973 10 Oct 1974] 49120/74 Heading A5B An orally-acceptable composition for remineralising dental enamel is obtained by freshly mixing (i) a first solution containing 0.005% to 5% by weight of calcium ions in the form of a water-soluble calcium salt with (ii) a second solution containing 0.005% to 5% by weight of phosphate ions in the form of a water-soluble phosphate salt or phosphoric acid, to form a metastable solution having a pH of from 2.0 to 5.0 and a molar ratio of calcium ions to phosphate ions of from 0.01:1 to 100:1. The first solution (i) may additionally contain a water-soluble salt of a polyvalent metal other than calcium e.g. Mg, Sn, Al, In, Mn, Zn, Zr, Fe, Ni, Ti, V, W, Al, Sr, Ti, and rare earth metals such as Ce, La, Sm, Pr and Nd, and the second solution (ii) may additionally contain a watersoluble salt of an anion which forms an insoluble precipitate with calcium or with said polyvalent metal e.g. a fluoride, fluorophosphate, carbonate, salt of a fatty acid having 8-18 carbons such as laurate or stearate, molybdate, sulphate, tungstate, tartrate, sorbate, alkyl sulphonate and iodate, or the second solution may also contain hydrofluoric acid. Suitable calcium salts for use in the first solution (i) are the chloride, acetate, formate, lactate and nitrate and suitable phosphate salts for the second solution (ii) are disodium hydrogen phosphate, sodium or potassium dihydrogen phosphates and trisodium phosphate. The solutions are aqueous but may also contain ethanol, glycerine or propylene glycol. The first and second solutions may be separately packaged in a kit for mixing immediately before use and such a kit may be suitable to prepare a toothpaste or a mouthwash.
[GB1488859A]
Autism affects 2-3% of youth, approximately half of whom experience a co-occurring anxiety disorder. Anxiety disorders in autistic youth are associated with significant life impairment and worsening trajectory without treatment. Cognitive behavioral therapy (CBT) is the recommended treatment for both autistic and typically-developing (TD) youth with anxiety, yet most families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. Access to CBT is particularly limited for Hispanic or Spanish-speaking families due to lack of services provided in Spanish. Internet-delivered therapies such as iCBT provide low intensity but effective intervention and overcomes barriers such as cost, travel, time from work/school, and stigma. Studies suggest that iCBT protocols for anxious typically-developing youth demonstrate moderate to strong effect sizes relative to control groups. However, until recently, such treatment models have not been developed with stakeholder engagement to be personalized for autistic children with anxiety and their families, including for those families that speak Spanish. In a previous Texas Higher Education Coordinating Board (THECB) funded work, a parent-led iCBT intervention for anxiety among autistic youth, Learning to Understand and Navigate Anxiety (LUNA) was developed. Over 60% of participants demonstrated response to treatment, yet children responded better than adolescents. Family feedback indicated that the materials were not developmentally appropriate for adolescents, necessitating further efforts to develop and evaluate an adapted version which is personalized to the unique needs of autistic adolescents with anxiety. The goal of this project is to increase access to care for families of autistic adolescents with anxiety through an internet-based treatment model (LUNA-Adolescent). This treatment model, developed by the study team, consists of an interactive website with both parent- and adolescent-facing treatment materials, supported by brief therapist contact (e.g. telehealth sessions), both in English and Spanish. Specifically, this project will evaluate the efficacy and cost effectiveness of LUNA-Adolescent compared to standard-care CBT for anxiety. Overall, this study will provide important information regarding the potential benefits of internet-based, parent-led interventions for autistic adolescents with anxiety and its two different delivery models.
PURPOSE:To obtain a hair growing agent containing a caloitonin generelated peptide. CONSTITUTION:Raw materials (e.g. animal or vegetable oil, mineral oil, ester oil, wax, alcohol and water) for hair growing agent are blended with 0.0005-2.0w/w% calcitonin gene-related peptide, a kind of peptide hormone in a vertebrate. Further the blend is optionally mixed with a medicinal component, a keratin solubilizer, a humectant, a germicide, a cell activator, vitamins, an antiseptic, a stabilizer, perfume, etc., to give the objective substance. The substance is prepared into a dosage form such as hair tonic, hair lotion, hair cream, aerosol or foam type. When the calcitonin gene-related peptide is administered to blood capillary, hair root is sufficiently provided with nutrition by vasodilatory action and blood stream promoting action to show hair growing effect.
The topological attributes of structural covariance networks (SCNs) based on fractal dimension (FD) and changes in brain network connectivity were investigated using graph theory and network-based statistics (NBS) in patients with noise-induced hearing loss (NIHL). High-resolution 3D T1 images of 40 patients with NIHL and 38 healthy controls (HCs) were analyzed. FD-based Pearson correlation coefficients were calculated and converted to Fisher's Z to construct the SCNs. Topological attributes and network hubs were calculated using the graph theory. Topological measures between groups were compared using nonparametric permutation tests. Abnormal connection networks were identified using NBS analysis. The NIHL group showed a significantly increased normalized clustering coefficient, normalized characteristic path length, and decreased nodal efficiency of the right medial orbitofrontal gyrus. Additionally, the network hubs based on betweenness centrality and degree centrality were both the right transverse temporal gyrus and left parahippocampal gyrus in the NIHL group. The NBS analysis revealed two subnetworks with abnormal connections. The subnetwork with enhanced connections was mainly distributed in the default mode, frontoparietal, dorsal attention, and somatomotor networks, whereas the subnetwork with reduced connections was mainly distributed in the limbic, visual, default mode, and auditory networks. These findings demonstrate the abnormal topological structure of FD-based SCNs in patients with NIHL, which may contribute to understand the complex mechanisms of brain damage at the network level, providing a new theoretical basis for neuropathological mechanisms.
The present invention relates to novel fusion proteins which activate transcription, to nucleic acid constructs encoding the proteins and their use in the genetic engineering of cells. Key fusion proteins of the invention contain at least two mutually heterologous domains, one of which being a bundling domain. Bundling domains include any domain that induces proteins that contain it to form multimers ("bundles") through protein-protein interactions with each other or with other proteins containing the bundling domain. Examples of bundling domains that can be used in the practice of this invention include domains such as the lac repressor tetramerization domain, the p53 tetramerization domain, a leucine zipper domain, and domains derived therefrom which retain observable bundling activity. Cells are engineered by the introduction of recombinant nucleic acids encoding the fusion proteins, and in some cases with additional nucleic acid constructs, to render them capable of ligand-dependent regulation of transcription of a target gene.  Administration of the ligand to the cells then regulates (positively, or in some cases, negatively) target gene transcription.
Variables will be tested for their association with the outcome using Pearson chi-square test for categorical data and Mann-Whitney U test for numerical data. Comparison the different groups will be conducted by using Mann-Whitney U test for numerical data and using Pearson chi-square test for categorical data. The time course of biomarker plasma levels will be assessed by analysis of variance. Multivariate analysis will be performed using a logistic regression model to estimate the odds ratio of organ failure and dying, along with the 95% confidence interval (CI). Forward and backward selection procedures will be used to iteratively select the variables potentially related to death.

Discrimination will be assessed using the area under the receiver operating characteristic curve to evaluate how well the model distinguished patients who lived from those who died and whether progression of organ dysfunction. A survival analysis will be performed using Kaplan-Meier curves and the log-rank test. Analyses will be completed and a two-tailed p\<0.05 will be considered significant.
There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.
"Silent" stroke post-TAVR presents as asymptomatic brain ischemic lesions detected on diffusion-weighted magnetic resonance imaging (DW-MRI), with an incidence ranging from 60% to 100% in different studies. On the contrary, hemorrhagic lesions are not systematically studied given the poor visualization of small hemorrhage (i.e. microbleeds) on traditional T1, T2 or DW-MRI sequences. We have previously identified an incidence of new brain microbleeds early after TAVR of 100% with the routine use of susceptibility-weighted imaging (SWI). We hypothesize that new brain microbleeds are prevalent in patients with aortic stenosis after either TAVR or SAVR. The key objective of this registry is to evaluate the incidence, distribution and clinical impact of new brain microbleeds after transfemoral TAVR in patients with symptomatic severe aortic stenosis, in comparison with SAVR.
Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the CSF has been associated with microglial activation in several neurodegenerative diseases. However, the basis for this immune-mediated attack and the pathophysiological role of sTREM2 in NMOSD remain to be elucidated. Here, we performed Mendelian randomization analysis and identified a genetic association between increased CSF sTREM2 and NMOSD risk. CSF sTREM2 was elevated in patients with NMOSD and was positively correlated with neural injury and other neuroinflammation markers. Single-cell RNA sequencing of human macrophage/microglia-like cells in CSF, a proxy for microglia, showed that increased CSF sTREM2 was positively associated with microglial dysfunction in patients with NMOSD. Furthermore, we demonstrated that sTREM2 is a reliable biomarker of microglial activation in a mouse model of NMOSD. Using unbiased transcriptomic and lipidomic screens, we identified that excessive activation, overwhelmed phagocytosis of myelin debris, suppressed lipid metabolism and enhanced glycolysis underlie sTREM2-mediated microglial dysfunction, possibly through the nuclear factor kappa B (NF-κB) signalling pathway. These molecular and cellular findings provide a mechanistic explanation for the genetic association between CSF sTREM2 and NMOSD risk and indicate that sTREM2 could be a potential biomarker of NMOSD progression and a therapeutic target for microglia-mediated neuroinflammation.
Pharmaceutical antibacterial compositions for oral, topical and parenteral administration comprise fusidic acid (antibiotic ZN-6) or a non-toxic salt thereof and a penicillinase-sensitive penicillin antibiotic or a non-toxic salt thereof.  Specified salts of fusidic acid include those of sodium and diethanolamine (preferred), potassium, ammonium, calcium, magnesium, triethylamine, piperidine, morpholine, cyclohexylamine, monoethanolamine, dibenzyl ethylenediamine, benzyl-b -phenylethylamine and procaine.  The compositions may be in conventional forms, e.g. ointments, aqueous and oily injections, pills, capsules, tablets, enterically coated tablets and tablets in which the active compounds are separated (particularly when the fusidic acid salt is that of a strong base) e.g. layered and "double" tablets prepared from separate granulations, each comprising one of the above types of antibiotic. Optionally, there may also be present antibacterial nitro-furan derivatives and sulphonamides, other antibiotics which are not absorbed in the intestinal canal and sulphamylbenzoic acid derivatives capable of delaying the excretion of penicillins. Specification 930,786 is referred to.
Participants in the Moderate Intensity Continuous Training group will first be warming up for 2.5 minutes at a VO2 max of 30%. After the warm up, participants will be running for 15 minutes at 45-60% of VO2 max. Finally, the participants will perform a 2.5-minute cool-down at 30% VO2 max, for a total exercise duration of 20 minutes.
FIELD: medicine. ^ SUBSTANCE: there is offered a method of precursor recovery from a human body, including all cells having stem cell characteristics or similar, in particular closely active or multiple active precursors, and such cells are recovered either directly, or indirectly from human breast secretion sampled from the specified human body. This secret can be colostrum, ripened milk or secretions in males and females in a lactation interval, during at least one of the following periods: absence of pregnancy, pregnancy period, lactation period, involution period. Further, the present invention refers to preferable applications of such recovered cells. ^ EFFECT: improved clinical effectiveness. ^ 24 cl, 8 dwg
The present invention relates to a composition of cosmetic ingredients for skin whitening and wrinkle amelioration using a Dendropanax morbiferus H. Lev. extract, and a production method thereof. More specifically, the present invention relates to a cosmetic composition for skin whitening and wrinkle amelioration, a composition of cosmetic ingredients for skin whitening and wrinkle amelioration using a Dendropanax morbiferus H. Lev. extract for producing the cosmetic composition, and a method for producing the cosmetic composition. According to the present invention, the cosmetic composition is produced by the following steps: fermenting medicinal herb ingredients including Dendropanax morbiferus H. Lev. so as to extract enzyme; fumigating the fermented ingredients with a fermented enzyme solution obtained by fermenting an enzyme solution used in the fermentation step; drying the same; and distilling using a distiller for oriental medicine. The cosmetic composition can be used as raw materials for cosmetic products for skin whitening and wrinkle amelioration.
The immunopathogenesis of dengue severity is convoluted. The primary objective of the research was to examine the dynamics of cytokine storm and its correlation with disease development in individuals affected by DENV infection. Additionally, the study aimed to discover potential biomarkers that could indicate severe dengue infection and determine the most suitable timeframe for predicting the severity of these biomarkers during the acute stage of dengue infections. We conducted a temporal analysis of the daily viral load and cytokine levels in 60 hospitalized dengue patients until discharge. Our findings reveal a distinct cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4 and decreased IL-12, MIP-1β) on the third day after symptom onset is predictive of severe dengue in secondary dengue infection. The imbalanced cytokine signature may inform clinical decision-making in treating severe dengue infections.
Participants will download the iBDecide app on their smartphone approximately two weeks prior to the scheduled clinic visit. Approximately one week after the clinic visit, survey data, along with demographic data will be collected from all participants via a brief telephone call. We will collect data on app use between installation and the clinic visit as well as in the 3 months following the clinic visit.
PROBLEM TO BE SOLVED: To obtain he subject novel compound, showing an antitumor function by suppressing growth of tumor cells. SOLUTION: This compound is shown by the formula, which belongs to Streptomyces. It is obtained by culturing a microorganism capable of producing the compound shown by the formula, e.g. Streptomyces sp. A54017, FERM P-16952 or its variant preferably at 14 to 34 deg.C and pH 4 to 8 for 24 to 168 hours, and recovering the compound from the culture system by an adequate separation method, e.g. solvent extraction and ion-exchanging with a resin. When this compound is used as an antitumor agent, it is preferably administered at 10 to 50 mg/day for an adult for oral administration, and 10 to 100 mg/day for parenteral ad ministration, preferably intravenous injection.
CC-486 (oral azacitidine), 300 mg total, taken daily on days 1-21 (of a 28 day cycle) for up to 12 cycles. Upon disease recurrence, subjects will start on a first-line chemotherapy.
The prevalence of TKA has increased dramatically during the last two decades, its popularity can be attributed to its evident success regarding pain improvement, deformity correction and disability reduction in knee osteoarthritis subjects. However, only a third of the patients report no functional problems after surgery, the 20% of then are unsatisfied with its functional skills and around a 20% are experiencing pain, high disability degrees and a significant quality of life reduction. This results cannot be fully explained by mechanical processes, surgical procedures or surgery variations, but it seems to be related to other psychological aspects. Chronic pain subjects often develop maladaptive thoughts and behaviours (i.e. pain catastrophism, Kinesiophobia, activity avoidance) which contribute to make the subject suffer physically as well as emotionally, and affect on the intensity and persistency of pain.

Although many psychosocial factors have been studied, pain catastrophism has emerged as one of the most important predictors for persistent pain after a total knee arthroplasty, as well as its severity and duration, that's why it is getting more importance when it comes to study chronic pain in this subjects. Reducing pain catastrophism has become a key factor to determine the success in the rehabilitation of some maladies accompanied by pain, considering that its reduction has been associated with the clinical improvement of pain itself. It has been observed that treatments using psychological and psychosocial interventions, therapeutic education and coping skills training, or physical therapy and therapeutic exercise, are effective techniques to reduce pain catastrophism. Nevertheless, it's still necessary to determine whether the maladaptive pain related thoughts approach, using physical therapy and behavioural techniques, are able to reduce the risk of suffering postoperative chronic pain.
Tumors are a heterogeneous group of cell masses originating in various organs or tissues. The cellular composition of the tumor cell mass interacts in an intricate manner, influenced by humoral, genetic, molecular, and tumor microenvironment cues that dictate tumor growth or suppression. As a result, tumors undergo a period of a dormant state before their clinically discernible stage, which surpasses the clinical dormancy threshold. Moreover, as a genetically imprinted strategy, early-seeder cells, a distinct population of tumor cells, break off to dock nearby or extravasate into blood vessels to secondary tissues, where they form disseminated solitary dormant tumor cells with reversible capacity. Among the various mechanisms underlying the dormant tumor mass and dormant tumor cell formation, heat shock proteins (HSPs) might play one of the most important roles in how the dormancy program plays out. It is known that numerous aberrant cellular processes, such as malignant transformation, cancer cell stemness, tumor invasion, metastasis, angiogenesis, and signaling pathway maintenance, are influenced by the HSPs. An accumulating body of knowledge suggests that HSPs may be involved in the angiogenic switch, immune editing, and extracellular matrix (ECM) remodeling cascades, crucial genetically imprinted strategies important to the tumor dormancy initiation and dormancy maintenance program. In this review, we highlight the biological events that orchestrate the dormancy state and the body of work that has been conducted on the dynamics of HSPs in a tumor mass, as well as tumor cell dormancy and reactivation. Additionally, we propose a conceptual framework that could possibly underlie dormant tumor reactivation in metastatic relapse.