anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
NEW MATERIAL:3,4-Diphenyl-1-benzylazetidin-2-one of the formula. USE:Useful as an anti-inflammatory, antipyretic, analgesic and antiphlogistic, antiallergic and immunological regulating agents, etc., and having strong inhibitory action on active oxygen species. PREPARATION:For example, 2,3-diphenylcyclopropenone is reacted with benzylamine in an inert organic solvent, e.g., benzene, at room temperature or a lower temperature than room temperature to give the compound of the formula. As an alternative method, a 1,3-dihalo-1,3-diphenylpropanone-2 is reacted with benzylamine preferably in the presence of an acid acceptor agent for the formed hydrogen halide, e.g. a carbonate of an alkali metal. The resultant reaction solution is then concentrated under reduced pressure and separated by chromatography to afford the aimed compound of the formula.
Colon polyps in colonoscopy images exhibit significant differences in color, size, shape, appearance, and location, posing significant challenges to accurate polyp segmentation. In this paper, a Weighted Dual-branch Feature Fusion Network is proposed for Polyp Segmentation, named WDFF-Net, which adopts HarDNet68 as the backbone network. First, a dual-branch feature fusion network architecture is constructed, which includes a shared feature extractor and two feature fusion branches, i.e. Progressive Feature Fusion (PFF) branch and Scale-aware Feature Fusion (SFF) branch. The branches fuse the deep features of multiple layers for different purposes and with different fusion ways. The PFF branch is to address the under-segmentation or over-segmentation problems of flat polyps with low-edge contrast by iteratively fusing the features from low, medium, and high layers. The SFF branch is to tackle the the problem of drastic variations in polyp size and shape, especially the missed segmentation problem for small polyps. These two branches are complementary and play different roles, in improving segmentation accuracy. Second, an Object-aware Attention Mechanism (OAM) is proposed to enhance the features of the target regions and suppress those of the background regions, to interfere with the segmentation performance. Third, a weighted dual-branch the segmentation loss function is specifically designed, which dynamically assigns the weight factors of the loss functions for two branches to optimize their collaborative training. Experimental results on five public colon polyp datasets demonstrate that, the proposed WDFF-Net can achieve a superior segmentation performance with lower model complexity and faster inference speed, while maintaining good generalization ability.
PURPOSE:To enable comparison of a radiation image under observation with a standard image without preparing hard copies, by refreshing and displaying side by side the radiation image based on a radiation image signal obtained by a retrieval means and a read means, and the standard image based on a standard image signal obtained by the retrieval means. CONSTITUTION:A radiation image signal S1 carrying radiation image information is obtained from a storage medium by a read means 1, subjected to an image processing by an image processing means 2 and sent to a display means 3. A piece of information S2 concerning the type of a subject corresponding to the radiation image signal S1 is input to a retrieval means 5 by an input means 4. A standard image signal S3 corresponding to the radiation image signal S1 is obtained from a large number of standard image signals stored in a storage means 6. The standard image signal S3 is sent to the image processing means to be subjected to an appropriate image processing if necessary. A standard image signal S3' is sent to a display means 3, which refreshes and displays the radiation image and the standard image side by side.
Gastric lavage or emesis plus catharsis as indicated. Alkalinize urine. If kidney function is normal, force fluids. If anuria is present, restrict fluids and salt, and treat appropriately. Catheterization of the ureters may be indicated for complete renal blockage by crystals. The low molecular weight of sulfasalazine and its metabolites may facilitate their removal by dialysis.
This group will receive 6 instructor-led 2 hour long didactic presentations regarding 8 key principles of self-efficacy and experiential exercises, including goal setting and problem solving with extensive group discussion. At the end of each session, tasks are assigned to participants to be completed outside the group during the week between sessions. Experiences from these activities and practice implementing the intervention principles will be shared and discussed each week, providing additional opportunities for problem solving and positive feedback.
Epigenetic regulation and mitochondrial dysfunction are essential to the progression of idiopathic pulmonary fibrosis (IPF). Curcumin (CCM) in inhibits the progression of pulmonary fibrosis by regulating the expression of specific miRNAs and pulmonary fibroblast mitochondrial function; however, the underlying mechanism is unclear. C57BL/6 mice were intratracheally injected with bleomycin (5 mg/kg) and treated with CCM (25 mg/kg body weight/3 times per week, intraperitoneal injection) for 28 days. Verhoeff-Van Gieson, Picro sirius red, and Masson's trichrome staining were used to examine the expression and distribution of collagen and elastic fibers in the lung tissue. Pulmonary fibrosis was determined using micro-computed tomography and transmission electron microscopy. Human pulmonary fibroblasts were transfected with miR-29a-3p, and RT-qPCR, immunostaining, and western blotting were performed to determine the expression of DNMT3A and extracellular matrix collagen-1 (COL1A1) and fibronectin-1 (FN1) levels. The expression of mitochondrial electron transport chain complex (MRC) and mitochondrial function were detected using western blotting and Seahorse XFp Technology. CCM in increased the expression of miR-29a-3p in the lung tissue and inhibited the DNMT3A to reduce the COL1A1 and FN1 levels leading to pulmonary extracellular matrix remodeling. In addition, CCM inhibited pulmonary fibroblasts MRC and mitochondrial function via the miR-29a-3p/DNMT3A pathway. CCM attenuates pulmonary fibrosis via the miR-29a-3p/DNMT3A axis to regulate extracellular matrix remodeling and mitochondrial function and may provide a new therapeutic intervention for preventing pulmonary fibrosis.
SAR442168 administered alone and together with rifampicin. 1 day washout for each administration of SAR442168.
The present invention discloses medicine for treating liver diseases. The medicine comprises the following components as raw materials (parts by weight): 3 to 12 parts of promoting blood circulation long, 2 to 10 parts of stir-baked cortex phellodendri with a salt solution, 2 to 10 parts of excrementum bombycis, 2 to 11 parts of angelica root, 2 to 10 parts of stir-baked radix bupleuri with vinegar, 2 to 10 parts of stir-baked atractylodes macrocephala, 2 to 10 parts of honey-fried radix astragali and 2 to 10 parts of liquorice root. The present invention has the preparing method that the raw materials are soaked in the conventional method; then, water whose amount is 7 to 9 times of the amount of the medicine is added into the raw materials, and the raw materials are decocted and boiled for 1 to 3 hours; physic liquor is taken for standby, water whose amount is 6 to 8 times of the amount of the medicine is added into the physic liquor, and the physic liquor is decocted and boiled for 1 to 2 hours; the physic liquor is filtered, and the physic liquor which is decocted and boiled for two times are combined and concentrated to form thick paste; tabletting is carried out by adopting well known technology; each tablet contains 0.4 gram of crude drug; at last, sugar is coated outside tablets, and the tablets are polished and dried, and are manufactured into sugar-coated tablets. The medicine of the present invention can also be manufactured into granule. A method for manufacturing the granule is the same with the public known preparation method of Chinese medicinal material granule. The medicine is mainly used for treating asymptomatic hepatitis B virus carriers, has the advantages of fast killing poison, fast improvement of liver functions and fast disappearance of clinical symptoms. After the medicine is taken for three months, the negative conversion rate of surface antigen can reach more than 50%, and therapeutic effects are stable; in addition, the present.
Hepatocellular carcinoma (HCC) is a lethal form of liver cancer, and the tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a critical role in its progression. This study aimed to elucidate the mechanism by which CAF-derived exosomes regulate the development of HCC. The study employed quantitative real-time polymerase chain reaction for mRNA expression analysis and western blot analysis for protein expression detection. Chromatin immunoprecipitation assay and dual-luciferase reporter assay were performed to investigate the relationship between zinc finger protein 250 (ZNF250) and programmed cell death 1 ligand 1 (PD-L1). Transmission electron microscopy and western blot analysis were used to characterize the isolated exosomes. The transferability of CAF-derived exosomes and normal fibroblasts (NFs)-derived exosomes into HCC cells was analyzed using a green fluorescent labeling dye PKH67. Cell proliferation was assessed via a 5-Ethynyl-2'-deoxyuridine assay, while Transwell assays were conducted to evaluate cell migration and invasion. Flow cytometry was performed to measure cell apoptosis, while enzyme-linked immunosorbent assays were used to assess the levels of tumor necrosis factor-α and perforin. Finally, a xenograft mouse model was constructed to examine the effects of exosomes derived from ZNF250-deficient CAFs on the tumor properties of HCC cells. The study revealed increased expression of ZNF250 in HCC tissues and cells, with ZNF250 transcriptionally activating PD-L1 in HCC cells. ZNF250 expression was associated with HbsAg, clinical stage and tumor size of HCC patients. CAF-derived exosomal ZNF250 can regulate PD-L1 expression in HCC cells. Furthermore, exosomes derived from ZNF250-deficient CAFs inhibited the proliferation, migration, invasion, and immune escape of HCC cells by downregulating PD-L1 expression. Moreover, CAF-derived exosomal ZNF250 promoted tumor formation in vivo. These findings provide insights into the role of CAF-derived exosomes in the suppression of HCC development, highlighting the significance of ZNF250 and PD-L1 regulation in tumor progression.
Unclear cystic masses in the pelvis in male patients are a rare situation and could be of benign or malignant origin. The underlying diseases demand for specific diagnostic and therapeutic approaches. We present a case series of 3 male patients with different clinical symptoms (perineal pain, urinary retention and a large scrotal cyst) related to cystic lesions in the pelvic region. On all patients initial histopathological workup was unclear. All patients underwent surgery with complete resection of the tumor which revealed a broad spectrum of histopathological findings: unusual form of cystic adenocarcinoma of the prostate, malignant transformation of a dysontogenetic cyst, and finally a very rare diagnosis of a malignant tumor of the Cowper gland. This case series and literature review provide clues for a possible diagnostic and therapeutic approach in the case of unclear pelvic cystic masses and could support urologists during the therapy selection in the future.
BACKGROUND: Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the role of the meningeal lymphatic system in SAE.
METHODS: Sepsis was established in male C57BL/6J mice by intraperitoneal injection of 5 mg/kg lipopolysaccharide, and the function of meningeal lymphatic drainage was assessed. Adeno-associated virus 1-vascular endothelial growth factor C (AAV1-VEGF-C) was injected into the cisterna magna to induce meningeal lymphangiogenesis. Ligation of deep cervical lymph nodes (dCLNs) was performed to induce pre-existing meningeal lymphatic dysfunction. Cognitive function was evaluated by a fear conditioning test, and inflammatory factors were detected by enzyme-linked immunosorbent assay.
RESULTS: The aged mice with SAE showed a significant decrease in the drainage of OVA-647 into the dCLNs and the coverage of the Lyve-1 in the meningeal lymphatic, indicating that sepsis impaired meningeal lymphatic drainage and morphology. The meningeal lymphatic function of aged mice was more vulnerable to sepsis in comparison to young mice. Sepsis also decreased the protein levels of caspase-3 and PSD95, which was accompanied by reductions in the activity of hippocampal neurons. Microglia were significantly activated in the hippocampus of SAE mice, which was accompanied by an increase in neuroinflammation, as indicated by increases in interleukin-1 beta, interleukin-6 and Iba1 expression. Cognitive function was impaired in aged mice with SAE. However, the injection of AAV1-VEGF-C significantly increased coverage in the lymphatic system and tracer dye uptake in dCLNs, suggesting that AAV1-VEGF-C promotes meningeal lymphangiogenesis and drainage. Furthermore, AAV1-VEGF-C reduced microglial activation and neuroinflammation and improved cognitive dysfunction. Improvement of meningeal lymphatics also reduced sepsis-induced expression of disease-associated genes in aged mice. Pre-existing lymphatic dysfunction by ligating bilateral dCLNs aggravated sepsis-induced neuroinflammation and cognitive impairment.
CONCLUSION: The meningeal lymphatic drainage is damaged in sepsis, and pre-existing defects in this drainage system exacerbate SAE-induced neuroinflammation and cognitive dysfunction. Promoting meningeal lymphatic drainage improves SAE. Manipulation of meningeal lymphangiogenesis could be a new strategy for the treatment of SAE.
The invention provides a process for preparing active component of reversal of the tumor multidrug resistance of fructus psoralea, which comprises the following procedures: fructus psoralea is disintegrated and immersed in 55-90 % ethanol with 2-5 times density for 3-7 days, and then filtered. The filtering liquid is collected and the ethanol is recycled and concentrated to viscous liquid and then 75-95% ethanol is charged. The viscous liquid is dissolved and placed for 2-5 days at room temperature. The dissolving liquid is filter-washed in 55-90% ethanol and the filter liquid is collected and concentrated to 1.02-1.04 relative density. The dry powder of the active component of reversal of the tumor multidrug resistance of fructus psoralea is obtained after the liquid which is filtered and concentrated is dried. The prepared active component of the invention has good effect to reversal of the tumor multidrug resistance, thereby the prepared the active component of reversal of the tumor multidrug resistance fructus psoralea can be applied in the preparation of conventional traditional Chinese medicine medicament forms, such as tablets, capsules, oral liquid, and granules and the like.
In their 2010 book, Lorna Weir and Eric Mykhalovskiy conceptualised the role of vigilance in unknown and emerging infectious disease threats. Theirs is a macro-level account which draws on empirical data to describe vigilance as a set of technical and political arrangements that govern collection, analysis, interpretation and communication of data as it pertains to unknown threats. In this paper we expand their work to detail a conceptual analysis of the role of vigilance at the micro-level during periods of high infectious disease threat. Our data are daily press conferences and associated non-discursive tools in New South Wales (NSW), Australia during times of heightened COVID-19 risk. This paper is a conceptual analysis that draws on theories of vigilance and related concepts to show how a key aspect of vigilance is making previously unseen threats visible or present. Communications formulated and encouraged three types of vigilance as a set of governing relations: institutional or authority-based; individual outward-facing; and individual inward-facing. We also describe the relationship between vigilance and related concepts that are used in response to anticipated public threats. Authority based vigilance involved contact tracing and policing of movement and behaviours. In individual outward facing vigilance people were asked to be alert to, analyse, and react to risk in their immediate environment. Inward facing vigilance required people to gather and react to information about their own behaviours and within their own bodies. There was a relationship between different types of vigilance; as risk increased and authority-based vigilance was less successful in containing the spread of infection, individual vigilance had a stronger role to play. This extension of vigilance at the micro-level sees some of the same unintended consequences as Weir and Mykhalovskiy describe at the global level, particularly in how burdens are inequitably distributed and experienced.
Antithrombotic agents, including antiplatelet agents and anticoagulants, are widely used in Korea because of the increasing incidence of cardiocerebrovascular disease and the aging population. The management of patients using antithrombotic agents during endoscopic procedures is an important clinical challenge. The clinical practice guidelines for this issue, developed by the Korean Society of Gastrointestinal Endoscopy, were published in 2020. However, new evidence on the use of dual antiplatelet therapy and direct anticoagulant management has emerged, and revised guidelines have been issued in the United States and Europe. Accordingly, the previous guidelines were revised. Cardiologists were part of the group that developed the guideline, and the recommendations went through a consensus-reaching process among international experts. This guideline presents 14 recommendations made based on the Grading of Recommendations, Assessment, Development, and Evaluation methodology and was reviewed by multidisciplinary experts. These guidelines provide useful information that can assist endoscopists in the management of patients receiving antithrombotic agents who require diagnostic and elective therapeutic endoscopy. It will be revised as necessary to cover changes in technology, evidence, or other aspects of clinical practice.
<P>PROBLEM TO BE SOLVED: To provide an implant for partially generating, reproducing or stabilizing at least vertebrae or tubular bones.  <P>SOLUTION: In this implant, a metallic hollow body is coated with an active substance complex or the metallic hollow body is filled with the active substance complex. The active substance complex has the following components being mutually different and particularly adapted for generating bones: that is, at least one kind of structural component based on an extracellular substance particularly adapted to a cell of a generating bone, at least one kind of replenishing component, at least one kind of adhesive component, and at least one kind of propagation and/or maturation component. The metallic hollow body is desirably composed of titanium or a titanium alloy, and is formed in a cylindrical shape forming a lattice structure. An active component can be applied to a support material selected from a polymer or collagen for reducing a quantity of required active component.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Eligible subjects who did not participate in Intravenous NAC or subjects who are at least 4 weeks after participation in Intravenous NAC, will be given Oral NAC at a dose of 2400mg daily, in two equally divided doses, for 4 weeks. Subjects will have blood drawn prior to beginning the phase and weekly for 4 weeks. At each visit interim medical events and adverse events will be collected.
The investigators conducted a controlled, randomised, prospective and double-blind trial. One hundred thirty eight participants were included, with American Society of Anesthesiologists physical status classification of I to II, with pregnancies of at least 36 weeks of gestation who were scheduled for elective caesarean delivery under spinal anaesthesia. One hour before induction of anaesthesia participants received a capsule containing sugar placebo (placebo group), pregabalin 150 mg or pregabalin 300 mg. Data related to surgical history, pre-existing medical problems, indications for cesarean and peroperative hemodynamic changes were analyzed. The primary outcome was first analgesic request. Secondary outcomes included maternal pain scores at rest and during movement, rescue analgesics consumption, sedation, nausea, vomiting, pruritus and Apgar scores. All maternal secondary outcome variables were recorded 0, 2, 4, 6, 12, 18, and 24 h after delivery. Common side effects linked to pregabalin such as somnolence, blurred or abnormal vision, or fetal distress were collected.
PURPOSE: A composition containing snowberry extract is provided to improve anti-wrinkle, anti-inflammation, whitening, moisturizing, and anti-aging. CONSTITUTION: A composition for preventing or relieving skin wrinkle contains snowberry extract as an active ingredient. A composition for preventing or treating inflammation contains snowberry extract as an active ingredient. A composition for skin whitening contains snowberry extract as an active ingredient. A composition for anti-oxidation contains snowberry extract as an active ingredient. The snowberry is Common snowberry, Mexican snowberry, Little leaf snowberry, Creeping snowberry, Western snowberry, Coralberry, Mountain snowberry or Chinese coralberry.
The present invention discloses a medicine in treating stomatocace. Said medicine is composed of litsea elongata fruit and its extract. It can be made into oral preparation, its preparation method includes the following steps preparing 3-5 weight portions of litsea elongata fruit, decocting them in water, concentrating the decoction to 100 weight portions, and it can be used for external application, and said external application method is characterized by that the litsea elongata fruit is crushed and applied to the affected region. Besides, 1-2 weight portions of litsea elongate oil can be taken orally, and the litsea elongata oil also can be applied to affected region for external application. In said invented medicine other medicinal materials of liquor, syrup and oil can be added. Its therapeutic effect is obvious.
PURPOSE:To obtain the title sol which has never been obtained conventionally by heating an aqueous suspension containing zirconium hydroxide to give an aqueous mixture containing crystallized zirconia, adding an acid to the aqueous mixture, peptizing the mixture and dehydrating the zirconia sol. CONSTITUTION:An aqueous suspension containing zirconium hydroxide is heated and maintained at >=80 deg.C until zirconia is sufficiently crystallized to give an aqueous mixture containing crystallized zirconia. Then the aqueous mixture is blended with an acid and zirconia is peptized to give sol of fine crystallized zirconia dispersed in an aqueous solvent. Then the acid is removed from the sol. Removal of the acid is not especially restricted and, for example, removal of low-boiling acid by heating, adjustment of pH>=5.0 with anion exchange resin, etc., may be cited as the removal of acid. Consequently, weakly acidic crystallized zirconia-based sol having pH of weak acidity, excellent dispersibility and dispersion stability is obtained.