anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
1324975 Microcapsule coated sheets FUJI PHOTO FILM CO Ltd 19 April 1971 [2 April 1970] 25792/71 Heading B2E A microcapsule coated sheet which does not develop high static electrical charge is made by coating a support sheet with a dispersion of the microcapsules, which may contain adhesives, dyes, foodstuffs, pharmaceuticals or perfumes, to which has been added a polymer containing a unit or units of wherein R is hydrogen, an alkyl group having 1 to 4 carbon atoms or an atom forming a water soluble salt with the carboxy group or an alkali metal salt or anhydride of such a carboxy containing polymer, and drying the coated support. The polymer is preferably present in amounts of between 0.5 and 4% of the dispersion which is preferably maintained alkaline. Suitable polymers are homopolymers of maleic acid, maleic anhydride or alkyl maleate or copolymers thereof, with vinyl ether, styrene, vinyl acetate, ethylene or butylene. The molecular weight of the polymer is preferably between 500 and 10,000. The microcapsules may be made by a coacervation method with gelatin or polymer-forming capsule walls. The support sheet may be of paper, plastic or laminated paper and plastic.
[GB1324975A]
Women with breast cancer (BC) overexpressing HER2 have more aggressive tumors and, without administration of anti-HER2agents, a shorter disease-free survival (DFS) and overall survival (OS) compared to patients with HER2-negative subtypes. Since the introduction of trastuzumab, the course of HER2-positive BC has notably improved in both metastatic and early settings. Indeed, anti-HER2 treatment has influenced the response to neoadjuvant (NAD). Women with breast cancer (BC) overexpressing HER2 have more aggressive tumors and, without administration of anti-HER2agents, a shorter disease-free survival (DFS) and overall survival (OS) compared to patients with HER2-negative subtypes. Since the introduction of trastuzumab, the course of HER2-positive BC has notably improved in both metastatic and early settings. Indeed, anti-HER2 treatment has influenced the response to neoadjuvant (NAD) therapy in HER2-positive BC by increasing the pCR rate. However, primary and acquired resistance to trastuzumab-containing regimens remains one of the major issues in clinical practice. Selecting patients that will benefit from anti-HER2 treatment is therefore essential. Overexpression of HER2 is identified in ∼20% of early-stage invasive BC and induces the downstream activation of the PI3K/AKT/mTOR pathway that plays a crucial role in developing resistance to trastuzumab: PIK3CA mutation and PTEN protein loss cause an hyperactivation of the pathway, whereas PIK3CA wild-type and retained or increased PTEN expression lead to a lower activation. PIK3CA mutations are predominantly found in hotspots located in the helical and kinase domains (exons 9 and 20), resulting in activation of the kinase. Another potential mechanism of resistance to trastuzumab is the estrogen receptor (ER) in those tumors that express both ER and HER2. To date, resistance biomarkers are lacking: despite the fact that data on PIK3CA mutations demonstrate significantly lower pCR rates, this has not led to an inclusion of the marker into routine diagnostics. PIK3CA can be investigated together with HER2 in pre-NAD tissue samples, in order to evaluate the correlation with response to NAD chemotherapy. That is an optimal setting to understand if PI3K could be considered a biomarker for HER2 therapy-resistant tumors and to select patients with poorer prognosis.

This study investigates the association of pCR with PIK3CA mutations and ER status and their prognostic value in HER2-positive BC treated with anti-HER2 therapy in addition to NAD chemotherapy.

Response to NAD therapy will be determined as pCR, defined as no invasive residuals in breast tissue and lymph nodes (ypT0/is, ypN0). Disease-free survival (DFS) will be defined as time in months from randomization to (local or distant) disease recurrence, secondary malignancy or death due to any cause. Overall survival (OS) was defined as time in months from randomization to death due to any cause.
Procedures for proper handling and disposal should be considered. Consideration should be given to handling and disposal according to guidelines issued for cytotoxic drugs. Several guidelines on this subject have been published.1-4 Caution should be exercised in the handling and preparation of Fludarabine Phosphate Injection solution. The use of latex gloves and safety glasses is recommended to avoid exposure in case of breakage of the vial or other accidental spillage. If the solution contacts the skin or mucous membranes, wash thoroughly with soap and water; rinse eyes thoroughly with plain water. Avoid exposure by inhalation or by direct contact of the skin or mucous membranes.
Within the scope of the conventional treatment Bobath Method, facilitating movement and functional activities in the upper and lower extremities, activating trunk muscles, facilitating basic functional activities such as turning in bed, coming to sit and standing, improving weight bearing while sitting and standing, postural control, balance and walking. A targeted exercise program will be created. In line with this goal, upper and lower extremity exercises; don't turn around, don't come to sit, don't stand up; Exercises to activate core muscles; such as bridging, functional reaching; weight bearing and balance training; It is planned to implement walking training. Treatment time will be 40-50 minutes.
The invention discloses a preparation method for a stem cell preparation capable of preventing and treating mycoplasma pneumoniae of swine. The preparation method comprises the steps of separating swine bone marrow mesenchymal stem cells from newborn swine leg bone marrows; separating a subtype cell BMSC-S3 cell line of the swine bone marrow mesenchymal stem cells; establishing a BMSC-S3/PBD-1 cell line stably transfected by PBD-1 gene; detecting genes expressed by BMSC-S3/PBD-1 cells by using PCR; and detecting antigen molecules expressed by the BMSC-S3/PBD-1 cells by using cellular immunofluorescence chemical analysis and flow cytometry. The BMSC-S3/PBD-1 cells prepared by the method can stably express PDB-1 and has the characteristics of standard BMSC stem cells. The BMSC-S3/PBD-1 cells stably transfected by the PBD-1 gene are injected into a swine body suffering from mycoplasma pneumoniae, with an effective dosage of 1-5*10<5> per time per kg of weight, so that mycoplasma pneumoniae diseases of the swine can be controlled. The BMSC-S3/PBD-1 cells can be stored in a liquid nitrogen container for a long time, so that sources can be guaranteed. The stem cell preparation provided by the invention has no drug resistance; and foreign protein is processed only by the swine body, without risk of drug residues, so that the stem cell protein has wide application prospects.
SABRIL causes edema in adults. Pediatric clinical trials were not designed to assess edema, but observed incidence of edema-based pooled data from controlled pediatric studies appeared similar for pediatric patients on vigabatrin and placebo.

Pooled data from controlled trials demonstrated increased risk among SABRIL patients compared to placebo patients for peripheral edema (SABRIL 2%, placebo 1%), and edema (SABRIL 1%, placebo 0%). In these studies, one SABRIL and no placebo patients discontinued for an edema related AE. In adults, there was no apparent association between edema and cardiovascular adverse events such as hypertension or congestive heart failure. Edema was not associated with laboratory changes suggestive of deterioration in renal or hepatic function.
After the training given with the demonstration method, the training videos on https://www.montgomerycollege.edu/academics/departments/nursing-tpss/nursing-simulation-scenario-library.html were shown to the participants using interactive training methods in parallel with this training. Each session lasted approximately 30-45 minutes. The sessions were repeated in the same environment on the same day and time, once a week, for a total of four weeks (four times).
Maltodextrin dextrose equivalent 10 is a fast digesting carbohydrate, is a non-sweet nutritive polymer that consists of D-glucose units linked primarily by \[alpha\]-1-4 bonds and that has a dextrose equivalent (D.E.) of less than 20. It is regarded as Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration for direct use as a food ingredient (GRAS, 21CFR184.1444).DE-1 Maltodextrin is commercially available. Participants will receive 21 individual containers of maltodextrin (30 g/container) and 21 cups of 4 oz unsweetened apple sauce. Participants will be asked to consume one maltodextrin container mixed in apple sauce at 10 a.m.; each day for 21 days.
This study is a prospective observational cohort study aimed at thoroughly investigating the disease progression and influencing factors of patients with moderate aortic valve disease, diagnosed at the Second Affiliated Hospital of Zhejiang University School of Medicine. Aortic valve stenosis and aortic regurgitation are the most common forms of aortic valve disease. According to the 2021 ESC guidelines, moderate aortic stenosis (Moderate AS) is defined as an aortic valve area (AVA) of 1.0-1.5 cm2 on echocardiography (or AVA \<1.0 cm2 with an AVA index of 0.60-0.85 cm2/m2), a peak jet velocity (Vmax) of 3-4 m/s, and/or a mean transvalvular gradient (MG) of 20-40 mmHg. Moderate aortic regurgitation (Moderate AR) is defined as a regurgitant fraction between 30% and 50% or an effective regurgitant orifice area between 0.10-0.30 cm2.

While treatment guidelines for patients with severe AS are well-established, there is currently no clear consensus on the treatment of patients with moderate AS, and the subsequent disease progression for these patients remains unclear. Similarly, when the aortic valve shows only moderate regurgitation, surgical treatment is usually not required; the most important aspect is regular monitoring of disease changes, including regular echocardiographic examinations. It is noteworthy that the time span from moderate to severe aortic regurgitation can vary from 1 to 10 years, and the monitoring and early warning mechanisms for potential markers indicating disease deterioration are currently not well developed. The goal of this study is to identify all clinical characterization, biological, echocardiographic, and CT imaging parameters that may increase the risk of disease progression. The confirmation of these parameters will guide future research to develop medical and interventional treatment methods to reduce mortality associated with this disease. Patients participating in this study will undergo outpatient follow-up every 1 year after diagnosis and will undergo electrocardiography, echocardiography, blood analysis, and enhanced CT examinations at 1, 3, and 5 years (plus once if an endpoint event occurs). Through these comprehensive monitoring methods, we expect to more accurately assess changes in the patient\'s condition and provide a scientific basis for clinical decision-making.
The thiazides may decrease serum PBI levels without signs of thyroid disturbance.

Calcium excretion is decreased by thiazides. Pathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been observed in a few patients on prolonged thiazide therapy. The common complications of hyperparathyroidism such as renal lithiasis, bone resorption, and peptic ulceration have not been seen. Thiazides should be discontinued before carrying out tests for parathyroid function.

Insulin requirements in diabetic patients may be increased, decreased or unchanged. Diabetes mellitus which has been latent may become manifest during thiazide administration.
AIM: New-onset diabetes mellitus is a frequent and severe complication arising after liver transplantation (LT). We aimed to identify the risk factors for new-onset diabetes mellitus after liver transplantation (NODALT) and to develop a risk prediction score system for relevant risks.
METHODS: We collected and analyzed data from all recipients who underwent liver transplantation at the First Affiliated Hospital of Xi'an Jiaotong University. The OR derived from a multiple logistic regression predicting the presence of NODALT was used to calculate the risk prediction score. The performance of the risk prediction score was externally validated in patients who were from the CLTR (China Liver Transplant Registry) database.
RESULTS: A total of 468 patients met the outlined criteria and finished the follow-up. Overall, NODALT was diagnosed in 115 (24.6%) patients. Age, preoperative impaired fasting glucose (IFG), postoperative fasting plasma glucose (FPG), and the length of hospital stay were significantly associated with the presence of NODALT. The risk prediction score includes age, preoperative IFG, postoperative FPG, and the length of hospital stay. The risk prediction score of the area under the receiver operating curve was 0.785 (95% CI: 0.724-0.846) in the experimental population and 0.782 (95% CI: 0.708-0.856) in the validation population.
CONCLUSIONS: Age at the time of transplantation, preoperative IFG, postoperative FPG, and length of hospital stay were independent predictive factors of NODALT. The use of a simple risk prediction score can identify the patients who have the highest risk of NODALT and interventions may start early.
Integral diagnosis and/or therapy or tumours in hollow organs comprises topical admin. of gamma-aminolevulinic acid (ALA). Detection is effected by irradiation with light of wavelength 390-430 nm, pref. 410 nm, which causes tumours to fluoresce. A krypton ion laser is pref. used for this purpose. Therapy is by irradiation with light of wavelength 600-650 nm, pref. 630 nm, esp. using a neodymium-yttrium-aluminium-garnet (Nd:Yag) laser. Admin. is e.g. by inhalation into the bronchial system, topically to the cervix, instillation into the peritoneal cavity and topically or by instillation in the case of the bladder. USE/ADVANTAGE - Used esp. to detect and treat tumours (including cancerous and precancerous lesions) of the respiratory tract, peritoneal cavity, gastrointestinal tract, female genital tract and partic. urinary tract. The method enables the detection of early cancerous conditions which cannot be detected by endoscopy, thus reducing relapse and progression rates. Further, the method is more effective than procedures involving the i.v. admin. of porphyrin photosensitisers. In partic., because ALA has higher tumour selectivity (tumour to healthy tissue uptake = 20:1 compared with 2-5:1 for porphyrins), results can be evaluated visually rather than by computer-generated imaging and phototoxic side effects do not occur.
After 6 months of ZOLADEX treatment, 109 female patients treated with ZOLADEX showed an average 4.3% decrease of vertebral trabecular bone mineral density (BMD) as compared to pretreatment values. BMD was measured by dual-photon absorptiometry or dual energy x-ray absorptiometry. Sixty-six of these patients were assessed for BMD loss 6 months after the completion (posttherapy) of the 6-month therapy period. Data from these patients showed an average 2.4% BMD loss compared to pretreatment values. 

Twenty-eight of the 109 patients were assessed for BMD at 12 months posttherapy. Data from these patients showed an average decrease of 2.5% in BMD compared to pretreatment values. These data suggest a possibility of partial reversibility. Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/or progestins) to ZOLADEX is effective in reducing the bone mineral loss which occurs with ZOLADEX alone without compromising the efficacy of ZOLADEX in relieving the symptoms of endometriosis. The optimal drugs, dose and duration of treatment has not been established [see Patient Counseling Information (17.2)].
Cirrhosis, a chronic liver disease, significantly impairs wound healing due to complex alterations in physiology, including compromised immune function, poor nutritional status and altered blood flow. This prospective observational cohort study aimed to evaluate the effectiveness of the multidimensional combination therapy approach in enhancing wound healing among patients diagnosed with cirrhosis. The study was conducted from February to November 2023 in Shanghai, China, including 248 patients with cirrhosis experiencing poor wound healing. The combination therapy consisted of tailored pharmacological treatments, advanced wound dressings, dietitian-directed dietary regimens and supplementary therapies like negative pressure wound therapy (NPWT), stem cell and hyperbaric oxygen therapy. The interventions were customised based on comprehensive initial assessments of liver function, nutritional status and wound characteristics. Follow-ups were conducted to monitor response and adjust treatments accordingly. The patient demographic was varied, predominantly 41-60 years old, with the slight male predominance. The study demonstrated that after 3 months of treatment, wound sizes decreased significantly across all cirrhosis severity levels: mild (2.4-1.7 cm2 ), moderate (4.1-2.6 cm2 ) and severe (6.2-4.4 cm2 ). Healing rates improved to 90% in mild, 75% in moderate and 45% in severe cases over 6 months. Albumin levels increased by the average of +0.3 g/dL to +0.4 g/dL post-treatment across the severity spectrum. However, complication rates escalated with severity: Mild cases had a 10% infection rate, while severe cases had up to 30% infection rate. Combination therapy significantly improved wound healing in cirrhosis patients, with the extent of improvement correlated with the severity of the condition. Tailored, multidisciplinary approaches are critical in managing the intricate wound healing process in cirrhosis, effectively reducing healing times and improving overall treatment outcomes. These findings advocate for personalised care strategies and highlight the potential of integrating various treatment modalities to address the complex needs of this population.
Factors driving progression from steatosis (NAFL) to steatohepatitis (NASH) in patients with non-alcoholic fatty liver disease (NAFLD) remain largely unknown. Considerable data now indicate that steatosis per se is not a hepatotoxic event and may represent in fact a protective mechanism against free fatty acid (FFA)-induced toxicity. the investigators previously showed that Kupffer cells from NASH mice accumulate more toxic lipids (ceramides, diacylglycerols, sphingolipids) enhancing their proinflammatory polarization. Therefore, "quality" of accumulating lipids rather than "quantity" may play a central role in NAFLD progression. This is a pilot comparative study aiming to evaluate the presence of toxic lipids (such as free-fatty acids, ceramides, diacylglycerols, sphingolipids) in postprandial state after ingestion of a "western diet" in NAFL and NASH patients. The secondary outcomes were: to evaluate the relationship between postprandial circulating lipids and markers of liver injury and proinflammatory cytokines; to evaluate hepatotoxicity of postprandial lipids in vitro. A total of 24 consecutive patients (group 1: 12 NAFL patients; group 2: 12 NASH patients) with biopsy-proven NAFLD (liver biopsy \< 6 months) will be recruited. A dietary evaluation covering the 2 previous weeks will be performed. Detailed anthropometric data will be collected (body mass index, waist and hip circumferences, abdominal height, cutaneous skinfolds) and serum metabolic parameters (standard lipid profile, lipoprotein levels, fasting plasma glucose, insulin levels, C-peptide levels, hemoglobin A1c) will be evaluated. After a 12hours overnight fast, patients will undergo an oral "western diet" test consisting in the ingestion of a high saturated fat, high refined sugar, high fructose-meal called "western diet" (800 kcal/meal). Blood samples will be drawn at fasting and then 2, 4, 6 and 8hours after ingestion of the standard meal. Each time plasma and serum samples will be stored at -80°C for subsequent analysis. Lipidomics will be used to quantify each plasma lipid class (neutral lipids, phospholipids and fatty acid methyl esters). Serum levels of cytokines will be assessed using multiple assay technology. Markers of liver injury will be assessed (aminotransferases, Keratin 18 fragments, microRNA-122) in the serum. Hepatocytes will be cultured with plasma from NAFL or NASH patients, and incubated overnight. In vitro hepatotoxicity will be evaluated using TUNEL assay, MTT assay and LDH release assay. the investigators anticipate that inflammation together with hepatocyte death will occur in NAFLD patients who develop specific postprandial plasma lipid changes with an increase in toxic lipid levels. Such patients may develop more severe liver lesions (inflammation, fibrosis/cirrhosis) and benefit of interventions. Identification of a toxic plasma lipid profile may help choosing the adequate diet in order to prevent deleterious lipid formation. Identification of a toxic postprandial plasma lipid signature specific to hepatotoxicity may also serve to develop a discrimination index to be further validated in clinical practice.
Patients will start their GVHD prophylaxis with Tacrolimus on Day -8. Patients will receive busulfan twice daily on Days -8, -7, -6, and -5; fludarabine on Days -7, -6, -5, -4, -3 and -2 and alemtuzumab on Days -5, -4, -3, -2, and -1. The double cord blood infusion will be performed on Day 0. GVHD prophylaxis will consist of tacrolimus/MMF.
A limited number of accidental overdoses of octreotide acetate injection in adults have been reported. In adults, the doses ranged from 2,400 to 6,000 mcg/day administered by continuous infusion (100 to 250 mcg/hour) or subcutaneously (1,500 mcg 3 times a day). Adverse events in some patients included arrhythmia, complete atrioventricular block, hypotension, cardiac arrest, brain hypoxia, pancreatitis, hepatitis steatosis, hepatomegaly, lactic acidosis, flushing, diarrhea, lethargy, weakness, and weight loss.

Octreotide acetate injection given in intravenous (IV) boluses of 1 mg (1,000 mcg) to healthy volunteers did not result in serious ill effects, nor did doses of 30 mg (30,000 mcg) given intravenously over 20 minutes and of 120 mg (120,000 mcg) given intravenously over 8 hours to research patients.

If overdose occurs, symptomatic management is indicated. Up-to-date information about the treatment of overdose can often be obtained from the National Poison Control Center at 1-800-222-1222.