anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obese individuals are at high risk for the development of hypertension and cardiovascular disease. Adipose tissue is a major source of pro-inflammatory molecules which can promote the development of atherosclerosis. Development of atherosclerotic plaques are mediated by oxidized or otherwise modified LDL cholesterol and infiltration of activated immune cells into the atherosclerotic lesions. Grapes contain high levels of polyphenols, a class of compounds known to possess antioxidant and anti-inflammatory properties. The overall goal of this proposal is to determine whether grape consumption can reduce the risk of cardiovascular disease by reducing the presence of inflammatory molecules and positively altering cholesterol levels, lipid profiles, and immune cell responses. Using a randomized cross-over design, twenty obese subjects will consume beverages containing either four servings of grape powder per day or the caloric equivalent without grape powder (placebo control) for a total of three weeks. After a two week washout period, the beverages will be switched for a further three weeks. Blood will be taken from each person at six intervals to determine lipid profiles, measure inflammatory markers in plasma, and analyze immune cell responsiveness.
MG patients are treated with tacrolimus as initial immune monotherapy. Symptomatic treatment like pyridostigmine bromide can be added to relieve symptoms (≤480mg/d).
The authors present a case of a 34-year-old female patient with von Willebrand disease who developed a recurrent right auricular keloid after childbirth. The patient had previously undergone surgical excision of the keloid in 2017, which led to the diagnosis of von Willebrand disease due to uncontrolled bleeding. After a successful pregnancy in 2023, the patient experienced keloid recurrence. Surgical excision and radiotherapy were performed in April 2023, followed by DDAVP administration to control postoperative bleeding. At 1-year follow-up, no recurrence was observed. This case highlights the potential impact of pregnancy on keloid recurrence and the challenges of managing keloids in patients with bleeding disorders.
PURPOSE: A health functional food is provided to improve skin wrinkling by controlling factors related to formation and decomposition of collagen. CONSTITUTION: Health functional food comprises processed extract of Panax species plant as an active ingredient that let sum of contents of ginsenoside Rg3, Rg5 higher than sum of content of ginsenoside Rb1, Rb2, Rc, and Rd. Processed Panax genus ginseng extract is manufactured as follows. Panax species plant is sliced and put in an autoclave to be heated at 70 °C to 150 °C, under 2 to 30 atmospheric pressure for 1 to 24 hours. Heated material is 1 or 20 times weight ratio(w/w) of water of sample weight, or low grade alcohol of C1 to C4 or mixture of these using cold extraction, hot water extraction, ultrasonic wave extraction, reflux cooling extraction, or heating extraction to be extracted. Extract is filtered, concentrated under reduced pressure, and dried. Health functional food is powder, granule, refinement, capsule or drink.
FIELD: pharmaceutical industry. SUBSTANCE: invention relates to biologically active agents preparing from the plant raw. Extraction of the milk ripeness dried oat is carried out with 35-70% an aqueous ethanol at ratio raw : extractant = 1:(35-60). The obtained biologically active complex shows general tonic effect. EFFECT: simplified technology, decreased cost, enhanced activity of an agent. 1 ex, 3 tbl
Vitamin D is a hormone that is important for bone and muscle health. As such, not having enough vitamin D in your body is associated with increased risk of injury and reduced health and athletic performance. It is often recommended that individuals who have low levels of vitamin D take vitamin D supplements. However, the effects of vitamin D supplementation on health and strength gains in collegiate athletes are not known. The goal of this study is to determine whether vitamin D supplementation increases strength and bone density, while reducing the risk of injury in collegiate athletes. Fasting vitamin D concentrations will be measured and athletes will be supplemented daily with Vitamin D for 8-12 weeks. The amount of supplementation will depend on whether the athlete is categorized as sufficient (\>30ng/ml), insufficient (20-35ng/ml), or deficient (\<20ng/ml). Vitamin D concentrations, strength, bone density, and injury risk will be assessed before and after the intervention period.
Disclosed herein are methods for inducing apoptosis by exposing cells to an apoptic inducing amount of one or more of newly created DAG-lactone mimetics. In one embodiment of the new class of DAG compounds the new DAG-mimetic compound satisfies general formula (I) as follows:, wherein R1, R2, R3, and R4 are independently selected from the group consisting essentially of hydrogen, oxygen, nitrogen, hydroxyls, halogens, branched or unbranched, substituted or unsubstituted, aliphatic groups, heteroatom (e.g., O, S, N, hydroxyls, halogens) substituted aliphatic groups, aromatic groups, and all major functional groups. Preferably, R1 is O and R3 is a hydroxyalkyl such as CH2OH. Also preferably, R2 is an alkylidene group derived from an aldehyde and R4 is an alkyl group derived from an acid chloride. The size of the lactone ring may be varied by either increasing or decreasing the ring size. Preferably, R1, R2, R3, and R4 when comprising carbon chains or rings, comprise groups of carbon chains or rings of 12 carbon atoms or less.
During Part 2, participants receive 225 mg adavosertib BID starting on Day 1 of each 21 day cycle for a total of 5 doses. Participants receive adavosertib in combination with paclitaxel (175 mg/m2) and carboplatin (AUC 5).
The invention relates to oral immediate-release capsules of a compound lansoprazole medicine composition, and a preparation method thereof. The compound capsules are composed of lansoprazole, sodium bicarbonate, and pharmaceutically acceptable auxiliary materials. According to the invention, lansoprazole raw material medicine particle size is controlled with a micronization technology, wherein a particle size is controlled within the range of d90 (19mum), d50 (4mum), and d10 (3mum). A gastric immediate-release effect is more substantial, and the medicine can be more easily absorbed by human bodies. With sodium bicarbonate, a direct effect of gastric acid secretion inhibition can be achieved, and also lansoprazole can be prevented from being degraded by gastric acid. Therefore, lansoprazole is better protected, and preparation stability is better.
Participants received the selected dose formulation of V503 (0.5 mL in a 3-dose regimen) from a Denmark, Norway, or Sweden site in the base study (V503-001, NCT00543543). No study vaccination will be administered in study V503-021.
The present invention discloses a multi-dimensional surface electromyogram signal prosthetic hand control method based on principal component analysis. The method comprises the following steps. Wear an armlet provided with a 24-channel array electromyography sensor to a front arm of a subject, and respectively wear five finger joint attitude sensors at a distal phalanx of a thumb and at middle phalanxes of remaining fingers of the subject. Perform independent bending and stretching training on the five fingers of the subject, and meanwhile, collect data of an array electromyography sensor and data of the finger joint attitude sensors. Decouple the data of the array electromyography sensor by principal component analysis to form a finger motion training set. Perform data fitting on the finger motion training set by a neural network method, and construct a finger continuous motion prediction model. Predict a current bending angle of the finger through the finger continuous motion model.
On Day 1, patients will be randomized to receive either APL-1401 or placebo in a 5:1 ratio. Patients will receive APL-1401 orally once daily (QD) during the 28-day treatment period.
For most children, having to endure a diagnostic or therapeutic procedure in a hospital environment is a frightening and distressing experience, especially if it is accompanied by pain or discomfort. In an attempt to minimise the trauma and to maximise co-operation from the child, administration of a sedative is often requested by either the parent or the proceduralist. Some sedative agents may have the side effect reducing the child's efforts in breathing, causing inadequate oxygen to be delivered to and carbon dioxide removed from the body, a state that can be life threatening if left untreated. Other sedative agents may cause unpleasant sensations such as hallucinations or nausea while still others may have a paradoxical effect of exciting rather than sedating the child. Among the available agents that may be administered without the presence of an attendant anaesthesiologist, dexmedetomidine is an agent of choice with minimal incidence of the aforementioned effects. However, we have observed in a small proportion of children that dexmedetomidine does not see to be able to elicit a sedative response in the expected time and with the usual dose. It is possible that there is a genetic bas to this resistance and it would be of great use to be able to predict the non-responders ahead of time so an appropriate alternative may be selected without a trial and error approach.

In this project, children who would require Precedex as first-line sedation for radiological or pre-anaesthesia sedation are asked to participate by providing a buccal swab sample and have their genome (genetic makeup) characterised by target sequencing. They are standardized into receiving 3mcg/kg intranasal Precedex and are observed every 5 minutes afterwards for their level of sedation. They would be identified as 'fast responder', 'normal responder', 'slow responder' and 'definite non-responder'.

A gene panel of 250 relevant genes is chosen and compared between the different groups of responders and non-responders. We will then try to look for the differences between these groups and we will use this information to build a predictive model. This model will help to identify non-responders in the future and this would allow clinicians to prepare for an alternative approach to sedation. This would save time, distress to the child and parent and ultimately cost to the institution.
The incidence of opportunistic, invasive fungal infections has dramatically increased over the past two decades and they cause high morbidity and mortality in a variety of patient populations. Voriconazole, a triazole antifungal agent, has shown in vitro activity against many yeasts and a variety of mold and dermatophyte isolates. Voriconazole can be administered either orally or parenterally. It exhibits good oral bioavailability and wide tissue distribution. Voriconazole is extensively metabolized by the hepatic cytochrome P450 isoenzymes, CYP 2C19, CYP 2C9 and CYP 3A4. The affinity of voriconazole is greatest for isoenzyme CYP 2C19 which exhibits genetic polymorphism with 15-20% of Asian populations being poor/slow metabolizers, whereas the prevalence is much lower (3-5%) amongst Caucasians and African Americans. Studies conducted in Caucasian and Japanese healthy subjects have demonstrated that poor metabolizers have, on average, four times higher voriconazole AUC than homozygous extensive metabolisers, while the AUC of heterozygous extensive metabolizers is two times higher than that of homozygous extensive metabolizers. The most commonly reported adverse events associated with voriconazole use include visual disturbances, liver function test abnormalities, and neurological complications. All of them have been reported to be associated with higher plasma concentrations and / or doses. In term of efficacy, an analysis showed a trend toward worse outcomes in patients with voriconazole plasma concentrations \< 0.5 μg/mL although this remains controversial. Since Asians have more CYP 2C19 polymorphism, we expect to see more patients with a wider range of voriconazole plasma concentrations than in previous studies in Caucasian patients. Our study will likely provide stronger evidence in explanation of the relationship between voriconazole plasma concentrations and clinical observations.

We plan to enroll patient who take voriconazole and examine their CYP 2C19 genotypes and plasma samples for peak and trough concentrations. We will collect potential confounding factors affecting voriconazole plasma concentrations, and correlate the concentrations with the dosing regimen, presence or absence of CYP 2C19 polymorphism, occurrence of adverse events, and treatment outcomes. The result of this study will be beneficial in clarify the international debate on controversial issue in the voriconazole plasma concentration monitoring. The ultimate goals of this study is to determine if monitoring of voriconazole plasma concentrations is desired in select patient populations or under certain circumstances in Taiwan.
OBJECTIVE: To evaluate the feasibility of endoscopic inspection of thoracolumbar and lumbar pedicle tracts in a canine large-breed model and its accuracy for the detection of breached versus nonbreached tracts.
ANIMALS: 2 greyhound cadavers.
METHODS: CT scans of 2 greyhound cadavers from the sixth thoracic vertebra to the sacrum were obtained. Fifty-six pedicles were randomized to have drill tracts with different modified Zdichavsky grades (nonbreached, partial/full medial breach, or partial/full lateral breach) using 3-D-printed guides. Endoscopy was performed on a single occasion from October 9 to 10, 2023, using a 1.9-mm 0-degree needle arthroscope in a randomized blinded fashion. The grading of drill tracts was performed on postoperative CT. Specificity, sensitivity, positive and negative predictive values, and time to assign endoscopic grade were investigated.
RESULTS: Postoperative CT confirmed 43 nonbreached tracts, 7 medial breaches (partial/full), and 5 lateral breaches (partial/full). One tract was excluded because of guide misplacement. Intraosseous endoscopy was successfully performed in the remaining 55 drill tracts. Sensitivity to detect medial and lateral breaches was 71.4% and 60.0%. Negative predictive value was 93.1%. Specificity was 94.2%. Positive predictive value for detection of medial and lateral breaches was 83.3% and 54.5%. Median (range) time to assign an endoscopic grade was 118 (30 to 486) seconds.
CLINICAL RELEVANCE: Intraosseous endoscopy of pedicle drill tracts may be a useful adjunct technique during pedicle screw/pin placement in dogs.
BACKGROUND: Splenic artery aneurysm (SAA) is characterized by a weakening and bulging of splenic artery. Robot-assisted (RA) laparoscopic surgery is a minimally invasive surgical technique. This systematic review aimed to assess the use of RA laparoscopic surgery to manage SAA.
METHODS: Five medical databases were used to identify studies that investigated the use of robotic devices in laparoscopic SAA management in humans. Original peer-reviewed articles were included. Two authors independently screened articles and extracted data on factors including patient demographics, surgical procedures, and outcomes.
RESULTS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses search identified 7 studies with a total of 28 patients who underwent RA laparoscopic surgery for SAA. The studies reported successful surgeries using various techniques, including end-to-end anastomosis, ligation, and graft placement. 3-dimensional printed models were used in 1 study as an aid for preoperative surgery planning. Mean operation time was 210 minutes, and 3 complications were reported (robotic arm failure during surgery and 2 conversions to open surgery).
CONCLUSIONS: RA laparoscopic surgery offers several advantages more than traditional open surgery for SAA management. However, more research is needed to confirm these potential benefits and establish RA laparoscopic surgery as a standard treatment option for SAA. Future studies should involve larger patient groups, compare this method to traditional techniques, and evaluate its cost-effectiveness. Additionally, incorporating advancements like mixed reality for preoperative planning and 3D printing to improve surgical planning and patient communication.
The present invention relates generally to growth factors and more particularly to growth factors which are capable of stimulating or otherwise facilitating formation of insulin-secreting cells. The identification of these growth factors permits the development of protocols to culture cells in vitro for transplantation into mammalian and in particular human subjects with insulin-dependent type 1 diabetes or related conditions. It is further contemplated that the endogenous expression of growth factors required for the development of insulin-producing cells may be manipulated in vivo, by the appropriate administration of agents including genetic agents capable of regulating the expression of growth factors in pancreatic duct epithelial cells. The growth factors may also be administered to subjects with type 1 diabetes to stimulate the proliferation and differentiation of pancreatic cells into insulin-secreting cells. The present invention also provides modulators of growth factor-mediated pancreatic cell differentiation. Such modulators are useful in the treatment inter alia of β cell tumors and/or pancreatic cancer.
Surgical interventions can be large or small, planned or urgent, but they have physiological and psychological effects on people. The most obvious physiological effects on the patient are: deterioration of organ functions and vascular system, change in body image, activation of stress-alarm reaction. Another of these physiological effects and the most common one is the changes in the gastrointestinal system. Postoperative ileus, which is defined as the temporary deterioration of gastric motility, causes pre- and postoperative diet restrictions, administration of anesthetics/narcotics, delay in gastric emptying as a result of excessive use of isotonic solutions, and slowing down in bowel movements due to excessive touching of the intestines, especially in abdominal and pelvic surgeries. It is known that current approaches and evidence-based practices regarding treatment and care in surgery can accelerate post-surgical recovery and reduce surgery-related deaths. In this direction, one of the evidence-based applications that has emerged to accelerate post-operative recovery is Enhanced Recovery After Surgery - ERAS, also known as Fast Track Surgery (FTS) protocol. With these new approaches, it has been proven that the time between the onset of bowel movements and the first gas formation is shortened, wound healing is accelerated, infection rates are reduced, and hospital stay is reduced. One of these approaches is coffee consumption in the postoperative period. Coffee is a popular beverage and its effects on general health, the central nervous system and the cardiovascular system are well known. Caffeine is a moderate central nervous system stimulant, and these effects are mediated by adenosine receptors. It acts as a potential antagonist of adenosine receptors in the nervous system. Caffeine and adenosine molecules are similar molecules. Caffeine binds to adenosine receptors, thus reducing the effectiveness of adenosine. As a result, we feel the stimulating effect of caffeine at the highest level. It has been observed that consuming more than 7 cups of coffee per day increases gastric secretion. It is also known that coffee increases bowel movements in healthy people. In a study conducted with patients who underwent laparoscopic orectal surgery, it was determined that bowel movements started 3 hours earlier than the patients in the control group and stayed one day less in the hospital. However, in the literature review, it is observed that there are very limited studies on this subject.

In the literature review, early oral feeding, mobilization and gum chewing were found to be effective in preventing paralytic ileus after abdominal and laparoscopic surgery, increasing patient comfort and shortening hospital stay. However, studies examining the effect of coffee consumption on bowel movements and hospital stay in the early postoperative period are very limited.

Based on this information, this study was planned to evaluate the effects of Turkish coffee and fennel tea drinking on GIS functions and healing quality in patients who underwent laparoscopic laparoscopic cholecystectomy surgery.
BACKGROUND: Hereditary breast cancer is characterised by the presence of a pathogenic sequence variant passed from one generation to the next. These cancers are aggressive, develop early, and account for 5 - 10% of all breast cancer cases. In South Africa (SA), the common variants that predispose to hereditary breast cancer have been well documented among white patients and form part of screening panels during targeted testing. For non-white patients, common variants are not well understood, and as such, all populations are offered the same test optimised for white patients. This carries a risk of misdiagnosis, the consequences of which include recurrence and increased mortality.
OBJECTIVES: To retrospectively describe genetic trends in the black African and Indian breast cancer patients from KwaZulu-Natal Province, SA.
METHODS: We reviewed clinical and genetic data of breast cancer and high-risk patients who consulted at Inkosi Albert Luthuli Central Hospital between 2011 and 2021. Inclusion criteria were based on clinical and demographic characteristics as defined by SA clinical guidelines.
RESULTS: Black African patients were young (mean 37.6 years, standard deviation 11.16) and had the majority of triple-negative tumours (37.5%). Indians represented 50% of bilateral breast cancers and of high-risk individuals. We identified 30 pathogenic BRCA1/2 sequence variants, four large genomic rearrangements and 13 variants of unknown significance. Twenty black patients carried 12, 13 white patients carried 4, 25 Indian patients carried 16, and 3 coloured patients carried 3 pathogenic sequence variants. The most frequent variants were BRCA2 c.5771_5774del, p.Ile1924fs among black patients, BRCA2 c.7934del, p.Arg2645fs among white patients, and BRCA2 c.8754+1G>A among Indian patients. None of the founder mutations common in white patients was reported in either black, Indian or coloured patients, which explains why black, Coloured and Indian SA patients consistently test negative during targeted screening.
CONCLUSION: This study highlights unique genetic trends for SA populations and the need for more inclusive targeted tests that are optimal for these populations.
An antimicrobial peptide variant having an amino acid sequence selected from SEQ ID NOs: 2-30 is provided. The antimicrobial peptide variant can have antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Staphylococcus aureus MRSA, Staphylococcus epidermidis, Cutibacterium acnes, or Clostridium perfringens. A composition, pharmaceutical composition, food additive, cosmetic composition, or hygiene product having an antimicrobial peptide variant including an amino acid sequence selected from SEQ ID NOs: 2-30 is also provided. The antimicrobial peptide can be an active ingredient in such compositions, additives, and products. A method of treating an infectious disease caused by bacteria is also provided. The method can include administering a pharmaceutical composition having the antimicrobial peptide as an active ingredient.