anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to surgery, and can be used in the treatment of patients with acute pancreatitis. To do this, in the postoperative period, drugs are delivered to the area of ​​the inflammatory focus through a catheter system consisting of a main catheter and three branched catheters connected through tee connectors. Branched catheters have micro-perforations along their entire length, and thin metal strings are placed inside each of them. In this case, the upper branched catheter is placed along the upper edge of the pancreas. The middle catheter is placed along the midline of the anterior surface of the pancreas. The lower catheter is placed up to 1.5 cm from the lower edge of the pancreas. Drugs sandostatin, L-lysine, 5-fluorouracil, aminocaproic acid 5% are administered alternately through the main catheter at a rate of 1 drop per 6 seconds. To remove excess fluid, a drainage tube with perforations made of rigid PVC with a diameter of 1 cm is used. Treatment is carried out around the clock for 5-7 days.EFFECT: implementation of the invention makes it possible to increase the effectiveness of the treatment of acute pancreatitis by blocking the secretory function of the pancreas, which contributes to the regression of the enzymatic cascade reaction.1 cl, 1 dwg, 2 ex
Once radiologic progression confirmed from atezolizumab monotherapy (stage 1), 1200mg of atezolizumab would be administered with 15mg/kg of bevacizumab as combination therapy (stage 2). Both of drugs are administered via intravenous infusion every 3 weeks.
The current study examined the relationship between compassion fatigue and professional self-concept in psychiatric nurses. Participants included 156 nurses working in a mental health and disorders hospital in Turkey. Data were collected via a sociodemographics form, the Compassion Fatigue subscale of the Professional Quality of Life Scale, and Professional Self-Concept Scale. Participants exhibited low levels of compassion fatigue and high levels of professional self-concept. A significant negative relationship was found between participants' mean compassion fatigue scores and mean professional satisfaction, professional competence, and professional self-concept scores (p < 0.05). Professional satisfaction, professional competence, and professional self-concept decreased with increasing compassion fatigue. Nurses should be provided emotional support through in-service training and effective communication to prevent burnout. [Journal of Psychosocial Nursing and Mental Health Services, 62(3), 22-28.].
<P>PROBLEM TO BE SOLVED: To enable accurate dispensing work and enhance safety for dispensing.  <P>SOLUTION: When patient data and dispensing data are extracted from an image of a prescription captured and inputted using a scanner 18, the drug data of a drug specified by the prescription are obtained from a drug DB according to the dispensing data to check the stock status of the drug. If the drug is in stock, the drug data obtained are displayed on a pharmacist's display device 13a; if the drug is out of stock, a search is conducted according to the drug data obtained to see whether or not there are any other drugs as effective as the drug. After dispensing is over and an image of the dispensed drug taken with a camera 19 is inputted, the image of the drug dispensed is compared to the image of the drug specified by the prescription, and if they do not match, an error message indicating that the dispensing is wrong is displayed on the pharmacist's display device 13a. Finally, the images of the drug taken and the drug data are printed using a printer 17 for output as instructions.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Patients will monitor their weight, blood pressure, oxygen saturation and symptoms with sensors and a tablet computer provided to them. Patients are asked to do this everyday for 60-days. A monitoring nurse receives and reviews the data electronically and will follow-up with the patient.
INTRODUCTION: Docetaxel plus ramucirumab (DTX + RAM) therapy is a standard treatment for previously treated lung cancer, but many adverse events have been reported. This retrospective study was conducted to examine if the side effects of DTX + RAM therapy can be minimized by the combined use of oral dexamethasone (DEX), and to assess the therapeutic effect of DTX + RAM in patients with recurrent lung cancer.
METHODS: Forty patients with relapsed non-small cell lung cancer who underwent DTX + RAM therapy were divided into two groups based on the concomitant use of oral DEX, and the therapeutic effects and toxicities in the two groups were compared.
RESULTS: The objective response rate (ORR) was significantly better in the DEX group (P = 0.0203). The median progression-free survival (PFS) was 5.20 months vs 2.87 months (P = 0.064) in the DEX and non-DEX groups, respectively. However, the median overall survival (OS) was significantly better in the DEX group (15.17 months vs 7.37 months, P = 0.0317). The frequency of fluid retention within six months of the start of treatment was 10.0% vs 42.5% in the DEX and non-DEX groups, respectively, with the fluid retention rate being significantly higher in the non-DEX group (P = 0.039).Conclusion: Concomitant use of oral DEX during DTX + RAM therapy may facilitate the long-term continuation of treatment and contribute to OS prolongation.
Research has shown that parent-targeted interventions are effective in ameliorating adolescent conduct disorders, substance abuse, HIV-risk, and related adolescent problem behaviors. The meteoric rise of Internet use and recent advance in multimedia technology and software combine to create new opportunities for disseminating evidence-based practices. Parenting Wisely (PW; Gordon, 2000) is a computer-based intervention designed to prevent and treat child disruptive behavior problems. This evidence-based approach fits easily into existing juvenile justice, health, education, and mental health service delivery systems, bypassing many of the current barriers to care. The investigators' Phase I study focused on revising and enhancing PW with more culturally relevant content and imagery to broaden its appeal to ethnically diverse populations. The findings revealed substantial improvements on virtually all measures of parenting and child behavior and outcomes at 6 months were highly significant and clinically meaningful. This Phase II study is designed to broaden the appeal and potential reach of PW through a formal randomized trial conducted in collaboration with the juvenile justice system (JJS), the primary market for such a program. Parents of 450 delinquent receiving JJS services as usual (SAU) will be randomly assigned to: PW plus a social networking online discussion forum, PW alone, or SAU. PW is the first online skill-building parent training program to examine effectiveness across different ethnic cultural groups and offers a brief, low cost, accessible approach that could be easily and quickly implemented and sustained in JJS settings. As such, the potential impact for marketing PW and reducing child behavior problems is considerable. Phase II activities will include the development of a moderated online forum to increase parental social support and skill acquisition. The investigators will also determine the potential marketability of the PW intervention to JJS programs based on the effects of PW on parent report and direct observation measures of parenting behaviors, adolescent behaviors, and family functioning, as well as measures of recidivism and cost savings. User satisfaction, program comprehension, receptivity, and parent self-efficacy will also be assessed.
Due to the particularity of children's eye structure, selecting the appropriate surgical approach for congenital cataracts presents challenging for ophthalmologists. The major concerned postoperative problem is the after-cataract formation. As a result, PCCC with A-Vit is usually performed to prevent the formation of secondary cataracts. However. Debate over the indication and surgical procedure still persists since A-Vit and excessive manipulations may interfere with the development of the eye and increase the risk of postoperative inflammation, unstable intraocular pressure, macular edema, retinal detachment and so on. Thus, it is necessary to evaluate the safety and effectiveness of PCCC without A-Vit in congenital cataract surgery.

In this randomized clinical trial, children with equal degree of congenital cataract in both eyes are enrolled. Patients receive cataract surgery on both eyes on the same day. For each patient, one eye is randomly assigned to undergo PCCC+A-Vit procedure, while the fellow eye is undergoing PCCC procedure without A-Vit. PCCC+A-Vit procedure includes anterior continuous curvilinear capsulorhexis (ACCC), irrigation/aspiration (I/A), PCCC, and A-Vit. Primary intraocular lens implantation (IOL) is performed in children older than age of two. Investigators then compare the incidence of visual axis opacity, uveitis, iris/pupil abnormality and intraocular pressure between two groups.
The invention relates to a process for the production of nanocrystals or amorphous nanoparticles of actives (nanomaterials), especially from the peels of grapes. According to the process of the invention, a dispersion of a micrometer-sized material in a solution of surfactant or a steric stabilizer is provided. The macrosuspension is then stirred for at least 1 minute at a rotational speed above 500 rpm. This stirring is effected using a rotor-stator mixer. Further, the mixture is passed through a jet stream or piston-gas type high pressure homogenizer. The process according to the invention is very economical and takes place under mild conditions. This excludes or minimizes any chemical decomposition. The nanomaterials according to the invention may be incorporated into formulations for use as nutraceutical, nutritional supplement, or as supportive treatment in medical therapy.
Randomized to receive depot Lupron for 6 weeks. Then randomized again to receive estrogen plus placebo for another 6 weeks.
Normotensive individuals age-matched to the hypertensive patients will receive only a single dose of sildenafil citrate (100 mg) - acute protocol. Penile and systemic microvascular function will be evaluated before and one hour after sildenafil administration.
PPG signal will be measured on CE certified medical devices. Measurement will be performed using reflectance and transmitance method on finger and in ear canal. The measurement will be 120s long.
OBJECTIVES: We planned to evaluate the association of fetal and maternal thyroid hormones and maternal iodine status with neonates' anthropometric parameters.
METHODS: In this cross-sectional study, levels of thyrotropin were measured in maternal serum in the first trimester of pregnancy, and thyrotropin (TSH) and free thyroxin (fT4) were measured in cord blood serum samples at birth. Urinary iodine concentration (UIC) levels in random urine samples of mothers were measured in the third trimester of pregnancy. The relationship between UIC and thyroid hormone levels of mothers with neonates' anthropometric birth parameters of neonates was evaluated.
RESULTS: One hundred eighty-eight mother-newborn pairs completed the study. Mean (SD) of cord blood TSH (CB-TSH), cord blood-free thyroxin (CB-FT4) values, and maternal TSH (M-TSH) levels were 8.8 (7.3) mIU/L, 1.01 (0.2) ng/dL, and 2.2 (0.9) mIU/L, respectively. After adjusting for confounders, there was a positive significant association between female neonate length and maternal TSH and log log-transformed CB TSH (LN_CB-TSH) (p<0.05). Median UIC (Q1-Q3) was 157 (53-241) μg/L, and there was no association between birth weight, birth length, and head circumferences of neonates and mothers' UIC (p>0.05).
CONCLUSIONS: We found a positive correlation between maternal TSH in the first trimester of pregnancy and the birth length of newborns, and a negative correlation was observed between CB-TSH and birth length in girls, but it did not provide conclusive evidence for the relationship between maternal and neonatal thyroid hormone levels and birth weight. There was no association between maternal UIC levels in the third trimester and birth anthropometric parameters.
MOSAIC treatment plus Usual NHS Care. MOSAIC treatment comprises 2 x 60-minute individual face-to-face consultations (weeks 1 \& 2) and 2 x 20-minute follow-up telephone calls (weeks 6 \& 12) with a trained physiotherapist.
In this study, in patients who are planned to have an intracranial mass operation with craniotomy, their medical histories, demographic features, comorbidities, preoperative radiotherapy treatment, the parameters examined in the preoperative routine will be collected as a file scan (previous operations, GKS, laboratory values). The classification of patients according to the 2016 World Health Organization Central Classification of Nervous System Tumors (WHO-CNS classification) and whether it is glial or non glial will be recorded from the clinical file. Intraoperative; hemodynamic data of patients; heart rate, diastolic, systolic and mean arterial pressures, fluid and blood products delivered, anesthetic and other medications, and blood gas samples will be written from the anesthesia document after the operation is finished. For the study, the application of the anesthesiologist for the patient will not be interfered. If postoperative patients are sent to the intensive care unit, their laboratory values and clinical observations (mortality, morbidity, neurological sequelae, imaging techniques, GOSE (Glasgow outcome skale)) will be recorded. In our study, mortality and morbidity will be evaluated 30 days postoperatively, and if the patient was sent to the service from the intensive care unit in this process, the values in the postoperative clinic (mortality, morbidity, neurological evaluation, imaging techniques, pathology results) will be recorded from the patient document. If the patient was discharged 30 days before, outpatient data will be recorded. The patients will be classified by evaluating the collected data (intraoperative hemodynamic data, blood transfusions, postoperative neurological sequel, postoperative complications and mortality).

In our study; the effects of lactate level on mortality and morbidity will be investigated in patients undergoing an intracranial mass operation with general anesthesia.
The invention provides a codonopsis pilosula fermented raw stock cosmetic, a preparation method thereof and an application thereof. The preparation method of the codonopsis pilosula fermented raw stock includes steps of mixing dry codonopsis pilosula powder, water and bacterium fluid and obtaining an initial system; fermenting and cultivating the initial system, and obtaining the codonopsis pilosula fermented raw stock. In the bacterium fluid, the culture is lactococcus lactis, in particular to lactobacillus. The application of codonopsis pilosula fermented raw stock in preparing the cosmetic with at least one function of 1)-4) or the application of directly using as the cosmetic with at least one function of 1)-4) is also in the protection scale of the invention: 1) remove DPPH free radical; 2) remove superoxide anion; 3) antioxidant; 4) anti-aging. The cosmetic is mask, essence or toner. By using the fermentation engineering technology, active matters are extracted from codonopsis pilosula; the operation is simple; for not adding any external substances, the codonopsis pilosula yeast prepared, or the codonopsis pilosula fermented raw stock is free from any harm to skin, and has higher anti-aging activity.
Pulmonary surfactant is required for normal lung function. Data from a previous study suggest that as many as 75% of chronically ventilated extremely low birthweight premature infants have at least one episode of surfactant dysfunction beyond the first week of life, as measured in vitro, associated with a low surfactant protein B content. Furthermore, episodes of surfactant dysfunction are significantly associated with clinically significant respiratory decompensations. We hypothesize that booster doses of surfactant given during the second and third week of life to extremely low birth weight premature infants requiring persistent intubation and mechanical ventilation will improve their respiratory status during the first 28 days of life. We propose to enroll premature infants \< 1250 gm birthweight, between days 7 and 10 of life who are intubated, and mechanically ventilated. Infants requiring persistent intubation and mechanical ventilation for respiratory support at 7-10 days of life will receive a total of 3 doses of Infasurf surfactant, 3 days apart, at the standard dose of 3 ml/kg. Primary outcome is the change in area under the respiratory severity score curve between days 7 and 28 of life. Total sample size is 88 infants, study duration is 36 months, and recruitment of study patients will occur at The Hospital of the University of Pennsylvania, in Philadelphia PA, Women and Children's Hospital in Buffalo, St. Louis Children's Hospital in St. Louis MO, Mercy Children's Hospital in Kansas City, Oakland Children's and Alta Bates Medical Center in Berkeley, CA and Long Island Jewish Medical Center, NY.
Functional neuroimaging studies suggest that a large-scale brain network transforms others' pain into its vicarious representation in the observer, potentially modulating helping behavior. However, the neuromolecular basis of individual differences in vicarious pain and helping is poorly understood. We investigated the role of the endogenous μ-opioid receptor (MOR) system in altruistic costly helping. MOR density was measured using [11C]carfentanil. In a separate fMRI experiment, participants could donate money to reduce a confederate's pain from electric shocks. Participants were generally willing to help, and brain activity was observed in amygdala, anterior insula, anterior cingulate cortex (ACC), striatum, primary motor cortex, primary somatosensory cortex and thalamus when witnessing others' pain. Haemodynamic responses were negatively associated with MOR availability in emotion circuits. However, MOR availability positively associated with the ACC and hippocampus during helping. These findings suggest that the endogenous MOR system modulates altruism in the human brain.
Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfunction is an important part of this pathogenesis. Carnitine palmitoyltransferase (CPT1A) is a key rate-limiting enzyme in the metabolic process of fatty acid oxidation (FAO). FAO regulates endothelial cell (EC) proliferation during vascular germination and is also essential for ab initio deoxyribonucleotide synthesis, but its role in EOPE needs to be further elucidated. In the present study, we investigated its functional role in EOPE by targeting the circHIPK3/miR-124-3p/CPT1A axis. In our study, reduced expression of circHIPK3 and CPT1A and increased expression of miR-124-3p in placental tissues from patients with EOPE were associated with EC dysfunction. Here, we confirmed that CPT1A regulates fatty acid oxidative activity, cell proliferation, and tube formation in ECs by regulating FAO. Functionally, knockdown of circHIPK3 suppressed EC angiogenesis by inhibiting CPT1A-mediated fatty acid oxidative activity, which was ameliorated by CPT1A overexpression. In addition, circHIPK3 regulates CPT1A expression by sponging miR-124-3p. Hence, circHIPK3 knockdown reduced fatty acid oxidation in ECs by sponging miR-124-3p in a CPT1A-dependent manner and inhibited EC proliferation and tube formation, which may have led to aberrant angiogenesis in EOPE. Thus, strategies targeting CPT1A-driven FAO may be promising approaches for the treatment of EOPE. KEY MESSAGES: Decreased Carnitine palmitoyltransferase (CPT1A) expression in preeclampsia(PE). CPT1A overexpression promotes FAO activity and tube formation in ECs. CircHIPK3 can affect CPT1A expression and impaire angiogenesis of EOPE. CircHIPK3 regulates CPT1A expression by acting as a ceRNA of miR-124-3p in HUVECs. Confirming the effect of circHIPK3/miR-124-3p/CPT1A axis on EOPE.
KIT ligand and its associated receptor KIT serve as a master regulatory system for both melanocytes and mast cells controlling survival, migration, proliferation and activation. Blockade of this pathway results in cell depletion, while overactivation leads to mastocytosis or melanoma. Expression defects are associated with pigmentary and mast cell disorders. KIT ligand regulation is complex but efficient targeting of this system would be of significant benefit to those suffering from melanocytic or mast cell disorders. Herein, we review the known associations of this pathway with cutaneous diseases and the regulators of this system both in skin and in the more well-studied germ cell system. Exogenous agents modulating this pathway will also be presented. Ultimately, we will review potential therapeutic opportunities to help our patients with melanocytic and mast cell disease processes potentially including vitiligo, hair greying, melasma, urticaria, mastocytosis and melanoma.
This was a prospective, open-label, multicenter, observational study. Participants who received bortezomib, Melphalan, Prednisone(VMP) therapy for Multiple myeloma (MM) that was not eligible for autologous stem cell transplantation will be enrolled in the study. The study will consist of Screening phase; VMP therapy phase (9cycles); Follow-up phase (2 years from the day when the first cycle was started). Participants visited each institution for evaluation for 2 years from the date of baseline evaluation and first VMP administration (duration of treatment, 9 cycles; follow-up visits, every 3 months after the end of the treatment). Participants receiving VMP therapy will be primarily evaluated for 2-year progression-free survival rate. Participants safety will be monitored throughout the study.
The purpose of the study is to investigate the combination VS-6063, carboplatin, and paclitaxel. in the treatment of patients with ovarian cancer. The study will evaluate whether this regimen is safe. The study will also evaluate whether the regimen can reduce the amount of cancerous cells in your body. If you agree, you will be treated with VS-6063 by mouth, as well as carboplatin and paclitaxel infusions. Carboplatin and paclitaxel are approved by the FDA for the treatment of ovarian cancer. VS-6063 is considered experimental because it is not approved by the FDA for the treatment of cancer.
The invention provides a preparing method for wolfberry fruit and schisandra chinensis tea. The wolfberry fruit and schisandra chinensis tea is specifically prepared from 100-130 g of vinegar-fried schisandra chinensis, 100-120 g of wolfberry fruits and 60-100 g of rock candy. The preparing method includes the steps that 1, the vinegar schisandra chinensis is prepared, wherein clean schisandra chinensis is taken, vinegar is added, the mixture is stirred to be even, tightly covered, placed in a suitable container and steamed till vinegar is absorbed completely and the surface is purple black, and the obtained product is taken out and dried; (15 kg of vinegar is added into every 100 kg of schisandra chinensis) 2, the vinegar-fried schisandra chinensis and the cut-up wolfberry fruits are put into a clean and heat-resistant container, 1500 ml of boiling water is poured, the container is tightly covered, and steeping is carried out for 3 days. The wolfberry fruit and schisandra chinensis tea replaces tea, and the using amount is not limited. The wolfberry fruit and schisandra chinensis tea can cure diseases such as appetite and weight losing in summer and emaciation. If the wolfberry fruit and schisandra chinensis tea is drunk for a long time, body functions can be effectively improved, and body immunity can be strengthened.