anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Left ventricular free wall rupture (LVFWR) and interventricular septal rupture (VSR) are potentially catastrophic mechanical complications after acute myocardial infarction (AMI). When they occur together, "double myocardial rupture" (DMR), survival is unlikely. DMR is seen in only 0.3% of all AMIs. With or without surgical intervention, the odds are against the patient.
CASE PRESENTATION: A 57-year-old male self-referred to the emergency department of a remote hospital 5 days after first experiencing chest pain. Investigations in ED confirmed an inferior ST-segment elevation myocardial infarction (STEMI) complicated by DMR. Coronary angiography revealed a mid-course total occlusion of the right coronary artery (RCA). He was rapidly transferred to our regional cardiac surgical unit, arriving straight into the operating theatre, in cardiogenic shock. He was briefly conscious, before arresting prior to intubation and being massaged onto bypass. Not only did he survive the all-night operation, requiring a mitral valve replacement in the process, but he survived multiple postoperative complications to be eventually transferred on postoperative day 66, neurologically intact, to a peripheral unit to complete his rehabilitation. He was subsequently discharged home 88 days after the operation and was able to ambulate with a walking frame into his first postoperative follow-up clinic appointment.
CONCLUSIONS: Our patient, against all odds, has survived DMR and multiple postoperative complications. We present the details of his case and the literature surrounding the condition. The patient's mental fortitude and his supportive family played a significant role, along with excellent multidisciplinary team work, in assuring his survival.
While performing heart rate estimation of a user, if the user is in motion, measured signal is prone to have noise data, which in turn affects accuracy of estimated heart rate value. Disclosed herein is a method and system for heart rate estimation when the user is in motion. The system estimates value of a noise signal present in a measured PPG signal by performing a Principle Component Analysis (PCA) of an accelerometer signal collected along with the PPG signal. The system further estimates value of a true cardiac signal for a time window, based on value of the true cardiac signal in a predefined number of previous time windows. The system then estimates frequency spectrum of a clean PPG signal based on the estimated noise signal and the true cardiac signal. The system further performs heart rate estimation based on the clean PPG signal.
The invention relates to a kind of animal agentia and the preparative of it, which has something to do with the animal drug technology. The material of the agentia is dandelion, which can relieve the fever, deintoxicate, lessen swelling and eliminate stagnation. The making procedures go as follows: remove the impurities of dandelion and clean it thoroughly; cut it into several sections and crush the dandelion; extract the smashed dandelion; mix the filtered solutions together; dry the solution into powder and smash it into refined dandelion powder. The extracting procedure includes two steps mainly, the first step is extracting the material in solution at ph2-5(adjusted by 10% acid solution) for 2 hours; the second step is extracting the material in solution at ph8-9(adjusted by 10% acid solution) for 8-9 hours. The agentia can treat the loimia of livestocks and poultries very effectively. The processing technology adopts the water-extracting method, besides it adopts acids before alkaline during extracting so that it can retain the effective ingredient of the drug. The effective ingredients of the refined powder have overcome the absorption problem of dandelion, so that the agentia can increase the economic benefits and decrease the producing cost of the animal agentia.
Complete sequestration of central nervous system tissue and cerebrospinal fluid by the dural membrane is fundamental to maintaining homeostasis and proper organ function, making reconstruction of this layer an essential step during neurosurgery. Primary closure of the dura by suture repair is the current standard, despite facing technical, microenvironmental, and anatomic challenges. Here, we apply a mechanically tough hydrogel paired with a bioadhesive for intraoperative sealing of the dural membrane in rodent, porcine, and human central nervous system tissue. Tensile testing demonstrated that this dural tough adhesive (DTA) exhibited greater toughness with higher maximum stress and stretch compared with commercial sealants in aqueous environments. To evaluate the performance of DTA in the range of intracranial pressure typical of healthy and disease states, ex vivo burst pressure testing was conducted until failure after DTA or commercial sealant application on ex vivo porcine dura with a punch biopsy injury. In contrast to commercial sealants, DTA remained adhered to the porcine dura through increasing pressure up to 300 millimeters of mercury and achieved a greater maximum burst pressure. Feasibility of DTA to repair cerebrospinal fluid leak in a simulated surgical context was evaluated in postmortem human dural tissue. DTA supported effective sutureless repair of the porcine thecal sac in vivo. Biocompatibility and adhesion of DTA was maintained for up to 4 weeks in rodents after implantation. The findings suggest the potential of DTA to augment or perhaps even supplant suture repair and warrant further exploration.
Collaboration between cancer treatment and inflammation management has emerged as an integral facet of comprehensive cancer care. Nevertheless, the development of interventions concurrently targeting both inflammation and cancer has encountered significant challenges stemming from various external factors. Herein, a bioactive agent synthesized by genetically engineering melanin-producing Bacillus thuringiensis (B. thuringiensis) bacteria, simultaneously achieves eco-friendly photothermal agent and efficient reactive oxygen/nitrogen species (RONS) scavenger benefits, perfectly tackling present toughies from inflammation to cancer therapies. The biologically derived melanin exhibits exceptional photothermal-conversion performance, facilitating potent photonic hyperthermia that effectively eradicates tumor cells and tissues, thereby impeding tumor growth. Additionally, the RONS-scavenging properties of melanin produced by B. thuringiensis bacteria contribute to inflammation reduction, augmenting the efficacy of photothermal tumor repression. This study presents a representative paradigm of genetic engineering in B. thuringiensis bacteria to produce functional agents tailored for diverse biomedical applications, encompassing inflammation and cancer therapy.
The aim of this study is to assess whether the retina of some patients has dried up after the first or second intravitreal injection of Aflibercept (EYLEA®) 2mg and in that event, to determine the proportion of these patients The analysis of the characteristics could help identify a morphotype that would predict whether and when the retina will dry up within the first 3 months of treatment. For some patients having an early drying-up, the third monthly injection might be not necessary 50 naïve patients will be included and will receive a monthly injection over 12 weeks with a biweekly follow-up. Morphological and functional characteristics will be recorded at each visit and will be analyzed. The rate of patients with dry SD-OCT will be assessed.

The study includes 7 visits. The visits are scheduled on an every 2-week basis from baseline to Week 12. V1 (baseline), V3 and V5, the patient will be injected with Aflibercept (EYLEA®) 2mg. In the other visits, the visual acuity test, Fundus photography, SD-OCT, and/or Fluorescein Angiography are performed
The invention provides a mint fermented original pulp cosmetic and a preparation method and application thereof. The preparation method of the mint fermented original pulp comprises the following steps: mixing dry mint powder, water and a bacterial fluid to obtain an initial system; fermenting and culturing the initial system to obtain the mint fermented original pulp. In the bacterial fluid, the strain is yeast. The invention also discloses the application of the mint fermented original pulp in the preparation of the cosmetic with at least one function of the following 1)-4): 1) DPPH free radical scavenging; 2 superoxide anion scavenging; 3) antioxidation; and 4) anti aging or the application of the mint fermented original pulp in use direct as the cosmetic with at least one function of the following 1)-4): 1) DPPH free radical scavenging; 2 superoxide anion scavenging; 3) antioxidation; and 4) anti aging. The cosmetic is a mask, essence or toner. The method utilizes the fermentation engineering technology for extracting active substances from mint, and is simple in operation, and due to no addition of any foreign material, the prepared mint fermented product, namely the mint fermented original pulp is harmless to the skin, and has higher anti-aging activity.
The invention discloses nourishing and health-care liquor which is prepared through unique formula and processing technique by taking of deer testes and penis, pilose antler, deer muscle, medlar, ginseng, red dates, cinnamon bark, hawthorn, Angelica sinensis, bighead atractylodes rhizome, Ligusticum wallichii, prepared rhizome of rehmannia, white paeony root, honey and crystal sugar as the main materials. Active pharmaceutical ingredients are mixed with the deer testes and penis, the pilose antler and the deer muscle, then water is added to the mixture to decoct, and finally the decoction is mixed with liquor, honey and crystal sugar. In this way, the efficacy and the quality of the nourishing and health-care liquor are improved, the nourishing and health-care liquor is fragrant and sweet in taste, has little flavor of a drug and is suitable for drinking, thereby the invention combines daily drinking with medical health care. The Chinese medicinal ingredients in the liquor are effective medicines for tonifying the kidney and Yang and have the efficacies of nourishing the blood and tonifying Yang. The liquor has the characteristics that the liquor contains rich nutrient substances while maintaining the mellow flavor of liquor, and has unique taste and the functions of regulating blood and vigor, balancing Ying and Yang and enhancing immunity. Therefore, the liquor can prevent and cure diseases, protect the human body against ageing and prolong life, and a drinker can get nourishment and health care effect whiling drinking the liquor.
Severe hypotension, particularly with upright posture, may occur with even small doses of nitroglycerin. This drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive. Hypotension induced by nitroglycerin may be accompanied by paradoxical bradycardia and increased angina pectoris.

Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.

As tolerance to other forms of nitroglycerin develops, the effect of sublingual nitroglycerin on exercise tolerance, although still observable, is somewhat blunted.

In industrial workers who have had long-term exposure to unknown (presumably high) doses of organic nitrates, tolerance clearly occurs. Chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence.

Several clinical trials in patients with angina pectoris have evaluated nitroglycerin regimens which incorporated a 10 to 12 hour nitrate-free interval. In some of these trials, an increase in the frequency of anginal attacks during the nitrate-free interval was observed in a small number of patients. In one trial, patients demonstrated decreased exercise tolerance at the end of the nitrate-free interval. Hemodynamic rebound has been observed only rarely; on the other hand, few studies were so designed that rebound, if it had occurred, would have been detected. The importance of these observations to the routine, clinical use of transdermal nitroglycerin is unknown.
Due to an alarming rise in opioid use among the general population that is mirrored in pregnant women, Neonatal Abstinence Syndrome (NAS) rates have increased in the US from 2004 to 2014. Most newborns experiencing NAS require non-pharmacologic care, which entails, most importantly, maternal involvement with her newborn. Facilitating postpartum maternal-newborn involvement is critical in preventing further adverse maternal-newborn outcomes. To achieve positive maternal-newborn involvement, mothers need to learn effective caregiving NAS strategies while they are pregnant. Surprisingly, current obstetrical practice standards for high risk pregnant women do not address this pressing need, in part because no interventions exist to prepare future mothers for the challenges of caring for their newborns at risk for NAS. To address this critical gap, the investigators propose to adapt an existing mobile NAS tool for clinician training and decision support, for high-risk pregnant women and assess its usability, acceptability, and feasibility in a small randomized controlled analog trial. First, the investigators will conduct semi-structured interviews with a panel of neonatology experts, NAS care providers, and mothers with NAS-affected babies to gather their recommendations on management of NAS and explore their perspectives on the care of these newborns. Findings will guide the adaptation of the existing mobile NAS tool for high-risk pregnant women. The investigators will then test the usability, acceptability, and feasibility of the adapted mobile tool via surveys with 10 pregnant women receiving opioid agonist therapy (OAT) at Spokane Regional Health District's Opioid Treatment Program and Evergreen Recovery Center. Finally, the investigators will randomize 30 high-risk pregnant women seen at these facilities to either receive the adapted mobile NAS caregiving tool or usual care. The investigators will compare these mothers on maternal drug relapse and OAT continuation, maternal-newborn bonding, length of newborn hospital stays, readmission rates, breastfeeding initiation and duration, and postpartum depression and anxiety at 4, 8, and 12 weeks postpartum. Findings will serve as pilot data for a subsequent large R01 randomized controlled analog trial testing the efficacy of the adapted NAS caregiving tool in reducing poor outcomes for NAS-affected newborns and their mothers.
Disclosed is a biological product containing the combination of garlic glycoside and garlic active components. The combination contains garlic glycoside molecules and garlic active components. The combination can be effectively used for beautifying and hairdressing, healthcare and medical therapy. The invention is pure biological product and is extracted after the mashed garlic is oxidized with air and alliin is decomposed by garlic enzyme. The extraction rate of the stable active components released from the deposited thick ethanol can reach 20-30 percent of the total quantity of the garlic. The combination has no strong garlic smell and has low extraction cost and high medical value.
PROBLEM TO BE SOLVED: To obtain a fat-reducing preparation for external use, capable of decreasing local fat by an easy means such as affixation and application, and further to provide a fat-reducing apparatus. SOLUTION: This fat-reducing preparation for external use comprises at least one of capsaicin, a homologue thereof and a derivative thereof, or a lipolysis component of vanillylamide of nonylic acid or the like, and a component for inhibiting the fat generation. The preparation is affixation preparation for the external use having a substrate layer and a medicine layer formed on the substrate layer and contacting with the skin, and containing a fat-degrading component and/or a component for inhibiting the fat generation in the medicine layer. The substrate can permeate the ultrasonic wave. The substrate is the porous one or has a lot of small holes, and further has an ultrasonic sound coupler, allowing the ultrasonic wave to be impregnated to the substrate to permeate.  When the medicine layer of the preparation for the external use is brought into contact with the skin, or when the preparation is applied to the skin as a spreading preparation for the external use, containing the component for degrading the fat and/or for inhibiting the fat generation, a physical stimulation-imparting means for imparting a physical stimulation from the outside of the body can be combinedly used therewith. The physical stimulation-imparting means is at least one kind of an ultrasonic wave, an electromagnetic wave or a machine vibration to a living body.
Developing a biodegradable sponge with rapid shape recovery and potent antibacterial and coagulation properties for traumatic hemostasis and anti-infection remains challenging. Herein, we fabricated quaternized silk fibroin (SF) sponges by freeze-drying under a constant cooling rate and modification with quaternary ammonium groups. We found the constant cooling rate enabled the sponges with a highly uniform pore structure, which provided excellent self-elasticity and shape recovery. Decoration with quaternary ammonium groups enhanced blood cells adhesion, aggregation, and activation, as well as resistance to infections from Staphylococcus aureus and Escherichia coli. The SF sponge had superior hemostatic capacity to gauze and commercial gelatin sponge in different hemorrhage models. The SF sponge exhibited favorable biodegradability and biocompatibility. Moreover, The SF sponge also promoted host cell infiltration, capillary formation, and tissue ingrowth, suggesting its potential for guiding tissue regeneration. The developed SF sponge holds great application prospects for traumatic hemostasis, anti-infection, and guiding tissue regeneration.
OBJECTIVE: To investigate the diagnostic and therapeutic value of direct visualization (single-use eyeMax subscope) endoscopic management of acute uncomplicated appendicitis.
METHODS: Thirty-six patients diagnosed with acute uncomplicated appendicitis, confirmed by computed tomography or ultrasonography, from Jan 2023 to Feb 2024 were enrolled in this study. We collected demographics, colonoscopy findings, subscope findings, clinical outcomes of endoscopic retrograde appendicitis therapy (ERAT), and adverse events associated with ERAT.
RESULTS: Appendiceal intubation was successful for all 36 patients. Thirty-five patients (97.2%) were definitely confirmed as having acute uncomplicated appendicitis. One patient with negative appendicitis was diagnosed as having cecal diverticulitis with fecalith incarceration. The mean procedure time was 13.1 ± 13.6 min. One patient presented with worsening abdominal pain, and a computed tomography scan suggested a perforated appendix. The mean length of hospitalizations was 1.78 ± 2 days. The mean follow-up was 158 days; during this period, two patients (5.6%) experienced recurrent abdominal pain after 23 and 88 days and subsequently underwent laparoscopic appendectomy.
CONCLUSION: Direct visualization ERAT may be effective for diagnosing and treating acute uncomplicated appendicitis and seems to have a low complication rate.
OBJECTIVE: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous manifestations and prognosis, and guide individualized therapy regimen.
METHODS: This inpatient cohort included 123 patients with MDA5+ DM. Unsupervised hierarchical clustering analysis was used to derive disease endotypes from the circulating immune cell profiles on admission. Clinical symptoms, laboratory test results, inpatient treatments, and disease outcomes were then analyzed among the identified endotypes.
RESULTS: Three disease endotypes in MDA5+ DM were identified from peripheral immune cell profiles. Endotype1 had the highest percentages of CD4+ T cells and monocytes, and the lowest percentage of neutrophils; Endotype2 had the highest percentage of B cells; Endotype3 had the highest percentage of CD8+ T cells and NK cells. Clinical and prognostic heterogeneity of the endotypes were revealed. Endotype1 had the lowest 3-month mortality with the high incidence of periungual capillary changes. Endotype2 and Endotype3 had higher prevalence of rapidly progressive interstitial lung disease (RPILD) and mortality at 3 months than Endotype1. Meanwhile, Endotype3 had higher pneumocystis jiroveci and CMV viremia cases with significantly elevated of activated CD8+ T cells and multiple cytokines than Endotype1.
CONCLUSION: Clustering analysis of peripheral immune cell profiles identified three different endotypes in MDA5+ dermatomyositis. Endotpye2 and 3 showed higher RPILD, 3-month mortality, pneumocystis jiroveci and CMV viremia.
<P>PROBLEM TO BE SOLVED: To develop a calcium channel-inhibiting or suppressing agent originating from a natural product, and to develop a substance containing the same.  <P>SOLUTION: This calcium channel-inhibiting or suppressing agent is characterized by containing a natural dipeptide : Val-Tyr (VY) or a substance containing the same as an active ingredient. The VY-containing substance includes the hydrolysate (sardine peptide) of a fish meat such as sardine. The VY or the VY-containing substance can be used not only for medicines but also for drinks or foods. The present invention has clarified that the VY has two actions of ACE (angiotensin-converting enzyme) inhibition and calcium channel inhibition in hypotension.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Paraduodenal Hernia (PDH) is an extremely rare cause of bowel obstruction. The true incidence of pediatric PDH is unknown since there are very few published cases of this phenomenon. PDH carries a high morbidity and mortality rate if unidentified. Proper diagnosis and prompt surgical intervention are extremely important. Our case is of a healthy 3-year-old male who presented with six days of generalized abdominal pain associated with constipation, anorexia, insomnia, and non-bloody, non-bilious emesis. Abdominal ultrasound (US) was negative for intussusception and failed to visualize the appendix. Abdominal x-ray (AXR) showed nonspecific distention of several loops of bowel with air-fluid levels. Computerized tomography (CT) scan was concerning for an internal hernia versus possible transverse colonic volvulus. The patient's abdominal pain and distension worsened after nasogastric (NG) tube placement. With the combination of physical and imaging findings, the patient underwent diagnostic laparoscopy. Intraoperatively, severely dilated bowel was encountered, which was decompressed via the appendix. After which, we discovered a PDH on the left side of the ligament of Treitz which was successfully reduced. The patient had no complications and continues tolerating a regular diet with return of normal bowel function. Our case describes successful laparoscopic surgical reduction of a pediatric left paraduodenal hernia.
The proportion of lower energy density items vs. higher energy density items will be reversed (67% lower - 33% higher) relative to the default proportion condition (33% lower - 67% higher). Lower energy density items will be defined as lower ED ≤ median of ED distribution within a food category.