anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Adolescents with moderate risk will receive the SPI-A intervention from the provider. Adolescents with high risk will be immediately taken to the mental health specialist at the primary care clinic. Following creation of the safety plan, patients are followed-up with at least twice to assess risk and review their plan. Following completion of the pilot, the investigators will interview all included providers as well as 18 adolescents who participated in SPI-A and their caregivers.
Microbiologicale prodn. of peptides or polypeptides (I) comprises first producing, simultaneously in the same medium, many genes (A) composed at least partly of stochastic, synthetic polynucleotides, and introducing these genes into host cells. The (A)-contg. strains are cultured so as to clone (A) and induce expression of proteins coded by (A). The modified strains are screened/selected to identify those which produce the required (I), according to a particular property. These strains are then isolated and cultured to produce (I). In modification, the (A)-contg. transformants are selected for presence of a particular stochastic DNA or RNA sequence, and such sequences recovered from cultures of the appropriate strains.
Patients with newly diagnosed, pathologically confirmed NK/T-cell lymphoma of stage III-IV treated with XCOPL regimen. 3 weeks for a cycle, with a total of 6-8 cycles. Initial safety and PET-CT assessment were performed after 3 cycles of treatment (which could be delayed until 4 cycles of treatment in special cases). Patients who achieved partial remission or above will continue the original regimen, and patients who did not achieve partial remission or above will perform re-biopsy and be excluded from the group. Patients who remain partial remission by PET-CT evaluation after 6 cycles may switch to a second-line regimen (referring to NCCN guidelines, GDP regimen combined with selinexor is recommended). Chemotherapy will be performed for up to 8 cycles (followed by autologous or allogeneic hematopoietic stem cell transplantation), after which follow-up period was entered. It is recommended to perform ultrasound or CT evaluation, peripheral blood ctDNA and EBV copy number every three months during the first year of follow-up, and PET-CT evaluation every half a year.
Doses of 0.5 to 1 mg of atropine are mildly stimulating to the central nervous system. Larger doses may produce mental disturbances; still larger doses are depressing. Death from atropine poisoning, though rare, is usually due to paralysis of the medullary centers.

Pregnancy

Teratogenic Effects

Pregnancy Category B. Reproduction studies have been performed in mice in doses of 50 mg/kg of body weight and have revealed no evidence of impaired fertility or harm to the fetus due to Atropine Sulfate. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
The invention belongs to the technical field of medicine, and relates to a nalmefene hydrochloride injection medicine composition and a preparation method, and particularly relates to a nalmefene hydrochloride injection medicine composition. The medicine composition comprises nalmefene hydrochloride. Particularly the medicine composition comprises the nalmefene hydrochloride, inorganic salt and injection water. The nalmefene hydrochloride in the medicine composition is added into the composition in a form of 17-(cyclopropyl)-4, 5alpha-epoxyl-6-methylene morphinan-3, 14-diol hydrochloride. Sugar is selected from one or more of mannitol, glucitol, lactose, maltose, maltitol, glycine, trehalose, glucose, dextran and the like. The medicine composition is an opiates receptor antagonist and is mainly clinically used for completely or partially inverting the effects of opiates drugs, including the respiratory depression caused by natural or synthetic opiates drugs. The injection is good in pharmaceutical properties such as excellent chemical stability and physical stability.
Itch and pain share many similarities and dissimilarities in terms of the mechanisms and molecules involved. Many studies have been conducted to explain all the neurophysiological aspects involved in the pain process, and cortical adaptations have been provoked in healthy individuals using experimental pain models. Unfortunately, all these aspects still need to be clarified regarding itch. Has been previously demonstrated that motor imagery can counteracted the pain-induced decrease in corticospinal excitability observed during acute pain, and it has also been proposed as a potential intervention for individuals with pain to restore maladaptive neuroplasticity. However, whether motor imagery can similarly counteract the itch-induced cortical changes remains unclear. Therefore, the aim of this project is to investigate whether motor imagery would counteract the reduction in cortical excitability during acute itch, similar to the effects observed in the context of acute pain.
Participants age 2 to less than (\<) 18 years of age (globally) and 8 to \<18 years of age (for US sites only) will receive nipocalimab once every two weeks for 24 weeks. After Week 24, all participants will have the option to enroll in long term extension (LTE).
There have been no reports of significant overdose with dexlansoprazole. Multiple doses of dexlansoprazole 120 mg and a single dose of dexlansoprazole 300 mg did not result in death or other severe adverse events. However, serious adverse events of hypertension have been reported in association with twice daily doses of dexlansoprazole 60 mg. Nonserious adverse reactions observed with twice daily doses of dexlansoprazole 60 mg include hot flashes, contusion, oropharyngeal pain, and weight loss. Dexlansoprazole is not expected to be removed from the circulation by hemodialysis.

In the event of over-exposure, treatment should be symptomatic and supportive.

If over-exposure occurs, call your poison control center at 1-800-222-1222 for current information on the management of poisoning or over-exposure.
<P>PROBLEM TO BE SOLVED: To provide a mechanism for enhancing security and improving convenience of operation of a system in processing medical information.  <P>SOLUTION: This medical system includes a user terminal 10 for processing medical information and a storage means 30 of the medical information. The user terminal 10 reads out identification information of a mobile medium, detects operation, and records the identification information in association with the operation when the operation is detected, and does not accept the operation from the user when the mobile medium is not detected, and accepts the operation when the mobile medium is detected. Thereby, even when a third party inputs after the user of the mobile medium, uses, and then leaves in the middle, the third party can not operate it when the third party does not have the mobile medium. When the third party has his or her own mobile medium, the third party can operate it but the user is recorded as the third party who uses the user terminal. Therefore, it can be prevented from being recorded that the user who finishes makes an input.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Clinical practice guidelines emphasize recommend weight gain prevention, but evidence-based treatments are not available in primary care. Balance, a pragmatic effectiveness trial, will test a scalable treatment approach for medically-vulnerable adults, those who suffer disproportionately from obesity and its adverse health effects. Balance builds on the design and findings of the Shape study (NCT00938535) to test a pragmatic intervention within rural community health centers. Balance will randomize overweight adults and adults with obesity who are patients a local community health center network (Piedmont Health Services) to either: 1) a 12-month weight gain prevention intervention or 2) usual care. Intervention group components include tailored behavior change goals; mHealth self-monitoring and feedback; skills training videos; and stepped responsive coaching from clinic Registered Dietitians. The usual care group will receive standard primary care offered by their providers and automated text messages and health information about maintaining a healthy weight. All intervention components and materials will be provided in Spanish or English.
Objectives. The paper proposes a novel methodology for the classification of Chronic Obstructive Pulmonary Disease (COPD) utilizing respiratory sound attributes.Methods. The approach involves segmenting respiratory sounds into individual breaths and conducting extensive studies on this dataset. Spectral Transforms, various Wavelet Transforms are applied to capture distinct signal features. Complex Network is also employed to extract characteristic elements, generating novel representations of spectrogram data based on graph factors, including entropy, density, and position. The normalized and enriched data is then used to develop COPD classifiers using six machine learning algorithms, fine-tuning with appropriate training details and hyperparameter tuning.Results. Our results demonstrate robust performance, with ROC curves consistently exhibiting an Area Under the Curve (AUC) > 96% across different time-frequency transformations. Notably, the Random Forest algorithm achieves an AUC of 99.67%, outperforming other algorithms. Moreover, the Wavelet Daubechies 2 (Db2) consistently approaches 98% accuracy, particularly noteworthy in conjunction with the Naive Bayes algorithm.Conclusion. This study diagnosis patients through spectrogram images extracted from lung sounds. The application of Inverse Transforms, Complex Network, and Optimized Classification Algorithms yielded results beyond expectations. This methodology provides a promising approach for accurate COPD diagnosis, leveraging Machine Learning techniques applied to respiratory sound analysis.
We aim to recruit 120 women with a history of irregular menstrual cycles, and no previous diagnosis of PCOS. An equal number of lean and overweight/obese women will be recruited within this group based on body mass index (BMI; Lean = 18 - 24 kg/m2 and overweight/obese ≥ 25 kg/m2).
Clinical studies for the treatment of anaphylaxis have not been performed in subjects aged 65 and over to determine whether they respond differently from younger subjects. However, other reported clinical experience with use of epinephrine for the treatment of anaphylaxis has identified that geriatric patients may be particularly sensitive to the effects of epinephrine. Therefore, for the treatment of anaphylaxis, consider starting with a lower dose to take into account potential concomitant disease or other drug therapy.   
  
Clinical studies of epinephrine for the treatment of hypotension associated with septic shock did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
All patients that develop chronic ankle instability after an ankle sprain and reporting at the emergency department. Experiencing persisting complaints of instability for more than 6 months.
The present invention relates to a modified natural killer (NK) cell and its use in personalised medicine. The modified NK cells of the present invention are non-immunogenic, meaning that they are able to be administered to any recipient subject without being rejected by the host immune system (they are “universal”). In a first embodiment the non-immunogenic NK cells are modified to express CD3 to allow a T-cell Receptor (TcR) to be expressed. In a further embodiment the non-immunogenic NK cells are further modified to express a TcR together with the CD3 co-receptor. Co-expression of CD3 with a specific TcR results in the modified NK cells showing antigen-specific cytotoxicity towards target cells. Universal NK cells can thus be targeted against specific antigens, and may thus be used in personalised medicine, particularly in the field of oncology.
<P>PROBLEM TO BE SOLVED: To provide a method for reconstructing an animal embryo and to provide the survival reconstructed animal embryo prepared by the method.  <P>SOLUTION: The method for reconstructing the animal embryo comprises transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated during the transfer so as to continuously bring a donor nucleus into contact with a recipient cytoplasm for a prescribed period. The diploid nucleus is obtained from any cell in the G0 phase or G1 phase of the cell cycle during the transfer. The resultant reconstructed embryo is then activated. The correct polyploidy is maintained during the activation by incubating the reconstructed embryo in the presence of a microtubular inhibitor, e.g. nocodazole. Furthermore, the reconstructed embryo gives births to one or more live animals. Therefore, the oocyte is useful for producing a transgenic animal and a non-transgenic animal of high genetic value.  <P>COPYRIGHT: (C)2007,JPO&INPIT
The proposed study will have a prospective, randomized, parallel design in which patients on chronic ticagrelor therapy will be assigned to receive a reloading dose of 90 or 180 mg ticagrelor. Platelet function assays will be done following in vitro incubation with and without 500 nM cangrelor.
Lumbar punctures (LP) are implemented for the diagnosis of patients with hematologic symptoms as well as for the intrathecal chemotherapy injections. Post lumbar puncture headache (PLPH) is a common complication in around 30% of patients. PLPH is characterized by the occurrence of a headache with an orthostatic component within 12-72 hours after LP with additional symptoms such as nausea. Even if this phenomenon spontaneously resolves within 3 to 5 days, symptoms can immobilize the patient and can interfere with his daily activities. Technical procedures largely influence the incidence of PLPH. Indeed, some studies in neurology, anesthesia and gynecology have previously shown a decreased incidence for PLHP while using atraumatic needles as compared to standard needles. So far, few data are available for hematology. In this context, it is necessary to better document the incidence of PLPH with the use of atraumatic needles in hematologic patients.
INTRODUCTION: Fistula formation and velopharyngeal insufficiency (VPI) are complications of cleft palate repair that often require surgical correction. The goal of the present study was to examine a single institution's experience with cleft palate repair with respect to fistula formation and need for surgery to correct velopharyngeal dysfunction.
METHODS: Institutional review board approval was obtained. Patient demographics and operative details over a 10-year period were collected. Primary outcomes measured were development of fistula and need for surgery to correct VPI. Chi-square tests and independent t tests were utilized to determine significance (0.05).
RESULTS: Following exclusion of patients without enough information for analysis, 242 patients were included in the study. Fistulas were reported in 21.5% of patients, and surgery to correct velopharyngeal dysfunction was needed in 10.7% of patients. Two-stage palate repair was associated with need for surgery to correct VPI (P = 0.014). Furlow palatoplasty was associated with decreased rate of fistula formation (P = 0.002) and decreased need for surgery to correct VPI (P = 0.014).
CONCLUSION: This study reiterates much of the literature regarding differing cleft palate repair techniques. A 2-stage palate repair is often touted as having less growth restriction, but the present study suggests this may yield an increased need for surgery to correct VPI. Prior studies of Furlow palatoplasty have demonstrated an association with higher rates of fistula formation. The present study demonstrated a decreased rate of fistula formation with the Furlow technique, which may be due to the use of the Children's Hospital of Philadelphia modification. This study suggests clinically superior outcomes of the Furlow palatoplasty over other techniques.
Ischemic heart disease, a leading cause of death worldwide, manifests clinically as myocardial infarction. Contemporary therapies using mesenchymal stromal cells (MSCs) and their derivative (exosomes, EXOs) were developed to decrease the progression of cell damage during ischemic injury. Laminin alpha 2 (LAMA2) is an important extracellular matrix protein of the heart. Here, we generated MSC-derived exosomes cultivated under LAMA2 coating to enhance human-induced pluripotent stem cell (hiPSC)-cardiomyocyte recognition of LAMA2-EXOs, thus, increasing cell protection during ischemia reoxygenation. We mapped the mRNA content of LAMA2 and gelatin-EXOs and identified 798 genes that were differentially expressed, including genes associated with cardiac muscle development and extracellular matrix organization. Cells were treated with LAMA2-EXOs 2 h before a 4 h ischemia period (1% O2, 5% CO2, glucose-free media). LAMA2-EXOs had a two-fold protective effect compared to non-treatment on plasma membrane integrity and the apoptosis activation pathway; after a 1.5 h recovery period (20% O2, 5% CO2, cardiomyocyte-enriched media), cardiomyocytes treated with LAMA2-EXOs showed faster recovery than did the control group. Although EXOs had a protective effect on endothelial cells, there was no LAMA2-enhanced protection on these cells. This is the first report of LAMA2-EXOs used to treat cardiomyocytes that underwent ischemia-reoxygenation injury. Overall, we showed that membrane-specific EXOs may help improve cardiomyocyte survival in treating ischemic cardiovascular disease.
Sickle cell anemia is a genetic disorder that results from a single nucleotide substitution in codon 6 of the beta-globin gene which, in the homozygous state, produces an abnormal hemoglobin that is prone to polymer formation when deoxygenated. The polymerized hemoglobin leads to impaired deformability and sickling of red blood cells which subsequently lodge in end-arterioles producing the classic and most prominent feature of the disorder, repeated vasoocclusive crises. Despite knowledge of the precise genetic defect for decades, only recently has there been therapeutic impact based upon this knowledge when a clear benefit from treatment with hydroxyurea, a cell cycle-specific agent administered to induce production of fetal hemoglobin (HbF) by stimulating gamma-globin synthesis, was reported in patients with sickle cell disease (SCD). The reduction in the frequency and severity of vasoocclusive crises seen has been attributed to the increase in HbF levels in responsive patients. While the majority of patients demonstrate a rise in HbF, not all such patients benefit from treatment. Given these results, alternative agents that also stimulate the production of HbF warrant investigation in the treatment of SCD. Recombinant-methionyl human stem cell factor (SCF) is a hematopoietic growth factor with activity on immature hematopoietic progenitor cells. SCF stimulates the production of HbF in vitro and in vivo, and this effect is attainable without the myelosuppression associated with hydroxyurea. In this phase I/II trial, we will administer SCF in a dose escalating fashion to patients with sickling disorders. Parameters to be measured are HbF levels, F cell levels, peripheral blood CD34 levels, frequency, duration, and severity of vasoocclusive crises, and toxicity.
The embodiment of the invention provides an auxiliary judging method, device, equipment and medium for endometrial cancer stage, and relates to the technical field of neural network auxiliary diagnosis. The auxiliary judging method comprises the steps S1 to S4. S1, acquiring an original MR I image containing a uterine region of a patient. S2, dividing according to the original MRI image through a pre-trained semantic division model, and obtaining a mask map of the uterine region. S3, performing edge recognition processing according to the mask map of the uterine region to obtain a contour map of the uterine region containing the focus. S4, predicting the antagonism network GAN through pre-trained generation according to the original MRI image and the outline map of the uterine region, and obtaining the outline map of the uterine region before illness. The auxiliary judging method finds the outline of the uterine region through the semantic segmentation classification model, and then generates a normal outline map of abnormal uterus through generating an countermeasure network GAN, so that a doctor is effectively assisted to diagnose endometrial cancer in stages.
BACKGROUND: The knowledge is sparse in the literature on intervention programs using nutritional support and physical activity for patients with chronic obstructive pulmonary disease within a person-centred approach. We aimed to explore and map the existing evidence on intervention programs with a person-centred approach, focusing on nutritional support and physical activity for people with COPD.
METHODS: A scoping review was conducted using Arksey & O'Malley's methodological framework. A search in the databases CINAHL and PubMed, and a grey literature search, was conducted in June 2022 and updated in June 2023. We identified studies published between 2012 and 2023. The PRISMA checklist for scoping reviews, supported by The PAGER framework was used for reporting the method.
RESULTS: A total of 15 studies were included. The primary interventions comprised behavior of change or self-management, addressing needs assessment, motivation, personal goals, education, and physical activity. Health-related quality of life and hospital stay displayed no clinically significant variances. However, eight studies demonstrated differences in physical function and activity levels. Nutritional outcomes were addressed in one study, and three studies involved relatives.
CONCLUSION: This scoping review addresses a knowledge gap in nutritional support interventions with a person-centred approach. It indicates that there is a need to increase nutritional support and consider the patient's physical and social environmental resources within Behavior of change or Self-management intervention programs for patients with COPD. The review found no clinical effect on health-related quality of life, although there were some effects on physical activity. The results highlight how the interdisciplinary team can include the patients' resources when structuring the management of COPD by applying a person-centred approach.