anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BRRI31R is one of the Bangladesh's most promising restorer lines due to its abundant pollen producing capacity, strong restoring ability, good combining ability, high outcrossing rate and genetically diverse from cytoplasmic male sterile (CMS) line. But the drawback of this line is that it is highly susceptible to bacterial blight (BB) disease of rice caused by Xanthomonas oryzae pv. oryzae. The present study highlighted the pyramiding of effective BB resistance genes (xa5, xa13 and Xa21) into the background of BRRI31R, through marker-assisted backcrossing (MABC). Backcross progenies were confirmed and advanced based on the foreground selection of target genes. Pyramided lines were used for pathogenicity test against five Bangladeshi Xanthomonas oryzae (BXo) races (BXo93, BXo220, BXo822, BXo826, BXo887) and confirmed the dominant fertility restore genes, Rf3 and Rf4 and further validated against SNP markers for more confirmation of target resistance genes. All pyramided restorer lines consisted of Xa4 (in built), xa5, xa13, Xa21, and Chalk5 with two fertility restorer genes, Rf3, Rf4. and these restorer lines showed intermediate amylose content (<25%). Restorer lines BRRI31R-MASP3 and BRRI31R-MASP4 showed high levels of resistance against five virulent BXo races and SNP genotyping revealed that these lines also contained a blast resistance gene Pita races. Gene pyramided restorer lines, BRRI31R-MASP3 and BRRI31R-MASP4 can directly be used as a male parent for the development of new BB resistant hybrid rice variety or could be used as a replacement of restorer line of BRRI hybrid dhan5 and 7 to enhance the quality of hybrid seeds as well as rice production in Bangladesh.
With the rise of people's health awareness and exercise habit in recent years, and the demand for the use of sports health food supplements has also increased. Probiotics are generally recognized as safe and helpful in digestion in the gastrointestinal tract. Previous animal experiments have found that probiotics LY-66, PL-02 are more effective in promoting the grip and exhausting exercise in mice. The purpose of this study is to further explore the effects of probiotics LY-66, PL-02 on promoting exercise endurance and explosive power in healthy people. This study is to compare supplementary samples with placebo and adopt a double-blind study design. 88 healthy adult males and females (non-sports players) aged 20-40 will be recruited, 44males and 44 females, with an average number of male and female subjects in each group, and they will be randomly assigned to the (A) placebo group, (B) LY-66 probiotic group, (C) PL-02 probiotics group, (D) LY-66/PL-02 doublet probiotics group. Supplemented one time a day, take 15 billion CFU of probiotics each time for 42 consecutive days. During the period of taking probiotics, squats and TABATA training were set for the subjects 2 days a week. From day 0 to day 42 of supplementation, subjects in each group were tested physical fitness and cardiorespiratory endurance every 14 days. On the 21th days, the explosiveness of muscle strength in each group was tested with Wingate. On the 42nd day, the exercise endurance test, NGS and GC-MS technology was used to detect the fecal microbiota and SCFA(Short-chain fatty acids) in each group, body inflammation index of each group were tested and use questionnaire to evaluate subjective experience. This study may discover that supplementing with probiotics LY-66, PL-02 can promote exercise endurance, explosive power and reduce muscle inflammation index in healthy people.
A system for operating medical devices is provided. The system may be used to program a medical device such as an infusion pump (120). The system may be implemented in a variety of ways including as a computer system. The system may include a first computer (104) at a pharmacy and a second computer (118) at a treatment location. The system sends operating parameters to the medical device after providing various checks to assure that the correct medication (124) is being administered to the correct patient. The system may also include features for confirming the operating parameters are still valid and features for sending alarms to the treatment location if there are discrepancies between the operating parameters, medication identifiers, and/or patient identifiers.
PURPOSE: Copeptin efficiently predicts post-neurosurgical central diabetes insipidus (CDI) in patients with hypothalamic-pituitary lesions, but its role in characterizing changes in diuresis in individuals with acromegaly undergoing neurosurgery remains unexplored. Our study aimed to assess changes in postoperative fluid balance in acromegaly patients and correlate them with both copeptin and growth hormone (GH) levels.
METHODS: This was a secondary analysis of a prospective study involving 15 acromegaly patients undergoing endoscopic endonasal resection at our University Hospital. Fluid balance was assessed daily, and copeptin and GH levels were evaluated preoperatively (T0), and serially on the morning of the first (T2) and second (T3) postoperative day, with an additional measurement of copeptin one hour post-extubation (T1). Patients with pre-existing or post-neurosurgical CDI were excluded from the analysis.
RESULTS: Most patients (11/15) exhibited a negative fluid balance on the second postoperative day, with 4 developing polyuria. Postoperative GH levels did not differ significantly between polyuric and non-polyuric patients, but GH measured at T2 correlated significantly with negative total balance (r = -0.519, p = 0.048). Copeptin levels at T1 were significantly higher in those who developed polyuria (p = 0.013), and a copeptin value > 39.9 pmol/L at T1 showed excellent ability (Sensitivity 100%, Specificity 90.9%, p < 0.001) in predicting postoperative polyuria. Additionally, polyuric patients exhibited a higher T1 / T3 copeptin ratio (p = 0.013) and a negative fluid balance was associated with the remission of acromegaly at 12 months (p = 0.046).
CONCLUSION: The early assessment of copeptin, in addition to facilitating the rapid identification of individuals at increased risk of developing CDI, could also allow the recognition of subjects with a tendency towards non-pathological polyuria in the postoperative setting, at least in individuals affected by acromegaly.
PROBLEM TO BE SOLVED: To prepare a hair-washing agent not only capable of washing hair and simultaneously massaging scalp with hands but also capable of extremely effectively removing wastes and adhered matters near to hair roots by adding a specific substance to a hair-washing agent. SOLUTION: This hair-washing agent is prepared by adding granules 2 to a hair-washing agent 1. The granules 2 may be produced e.g. by sealing an ingredient effective for removing matters adhered to hair roots, a hair-growing ingredient, vitamins, etc., in capsules having such a breaking strength as broken with a proper force on the massage of hair. The granules 2 may comprise finely ground plant seeds, etc. The employment of the hair-washing agent enables to easily remove the matters adhered to the hair roots. A massage effect due to the friction of the granules 2 enables to stimulate blood circulation, enhance metabolism and thereby further enhance the hair-growing effect. Since the above two treatments can simultaneously be carried out, a time required for the growth of hair can considerably be shortened.  When the hair-washing agent is used before the employment of a conventional hair-growing agent, the effect can remarkably be improved.
Continuous infusion of fentanyl and midazolam is started per protocol. Both drugs are titrated to target pain score (0 to 3) using Critical Care Pain Observation Tool (CPOT) and target sedation score (0 to -3) using Richmond Agitation Sedation Scale (RASS). Daily interruption of fentanyl and midazolam is not performed. Every morning 120-min CPAP trial is performed as long as the patient's RASS score is 0 to -2 and the patient passes the SBT safety screen.
The invention discloses a composition having a bowel relaxing function, a preparing method thereof and applications thereof. The composition comprises following components by volume: 75-85 parts of aloe juice, 5-15 parts of a first plant oil component, and 5-15 parts of a second plant oil component. The first plant oil component comprises walnut oil, pine-seed oil and grape seed oil. The second plant oil component comprises black sesame oil, linseed oil, apricot kernel oil, sunflower seed oil and olive oil. The composition adopts an anus administration manner. By the function of the composition, the intestinal wall of the rectum is fully lubricated, faeces are not dry any longer, success defecation after taking the medicine can be achieved, and long-term using of the composition can improve symptoms of constipation. The composition is free of allergens, free of irritation and free of side effects. A constipation patient is free of any discomfort after using the composition.
The objective of the study was to use a deep learning model to differentiate between benign and malignant sentinel lymph nodes (SLNs) in patients with breast cancer compared to radiologists' assessments.Seventy-nine women with breast cancer were enrolled and underwent lymphosonography and contrast-enhanced ultrasound (CEUS) examination after subcutaneous injection of ultrasound contrast agent around their tumor to identify SLNs. Google AutoML was used to develop image classification model. Grayscale and CEUS images acquired during the ultrasound examination were uploaded with a data distribution of 80% for training/20% for testing. The performance metric used was area under precision/recall curve (AuPRC). In addition, 3 radiologists assessed SLNs as normal or abnormal based on a clinical established classification. Two-hundred seventeen SLNs were divided in 2 for model development; model 1 included all SLNs and model 2 had an equal number of benign and malignant SLNs. Validation results model 1 AuPRC 0.84 (grayscale)/0.91 (CEUS) and model 2 AuPRC 0.91 (grayscale)/0.87 (CEUS). The comparison between artificial intelligence (AI) and readers' showed statistical significant differences between all models and ultrasound modes; model 1 grayscale AI versus readers, P = 0.047, and model 1 CEUS AI versus readers, P < 0.001. Model 2 r grayscale AI versus readers, P = 0.032, and model 2 CEUS AI versus readers, P = 0.041.The interreader agreement overall result showed κ values of 0.20 for grayscale and 0.17 for CEUS.In conclusion, AutoML showed improved diagnostic performance in balance volume datasets. Radiologist performance was not influenced by the dataset's distribution.
Telmisartan and Hydrochlorothiazide   
In controlled clinical trials with more than 2500 hypertensive patients, 1017 patients were exposed to telmisartan (20 mg to 160 mg) and concomitant hydrochlorothiazide (6.25 mg to 25 mg). These trials included one factorial trial (Study 1) with combinations of telmisartan (20 mg, 40 mg, 80 mg, 160 mg, or placebo) and hydrochlorothiazide (6.25 mg, 12.5 mg, 25 mg, and placebo). The factorial trial randomized 818 patients, including 493 (60%) males; 596 (73%) Non-Black and 222 (27%) Blacks; and 143 (18%) ≥65 years of age (median age was 53 years old). The mean supine blood pressure at baseline for the total population was 154/101 mmHg. 

The combination of telmisartan and hydrochlorothiazide resulted in additive placebo-adjusted decreases in systolic and diastolic blood pressures at trough of 16 to 21/9 to 11 mmHg for doses between 40 mg/12.5 mg and 80 mg/25 mg, compared with 9 to 13/7 to 8 mmHg for telmisartan 40 mg to 80 mg monotherapy and 4/4 mmHg for hydrochlorothiazide 12.5 mg monotherapy. The antihypertensive effect was independent of age or gender. There was essentially no change in heart rate in patients treated with the combination of telmisartan and hydrochlorothiazide in the placebo-controlled trial.

Four other studies of hypertensive patients of at least six months’ duration allowed add-on of hydrochlorothiazide for patients who either were not adequately controlled on the randomized telmisartan monotherapy dose or had not achieved adequate blood pressure response after completing the up-titration of telmisartan. In active-controlled studies, the addition of 12.5 mg hydrochlorothiazide to titrated doses of telmisartan in patients who did not achieve or maintain adequate response with telmisartan monotherapy further reduced systolic and diastolic blood pressures.
For the purpose of this study the EndoRotor System is investigationally indicated for use during endoscopic procedures to resect and remove refractory Barrett's esophagus tissue in conjunction with a submucosal saline injection mix using adrenaline and dye. Subjects randomized to the EndoRotor arm will be treated up to 3 times through the 9 month follow-up period to remove gross visible Barrett's.
Many inhalation exposures induce pulmonary inflammation contributing to disease progression. Inflammatory processes are actively regulated via mediators including bioactive lipids. Bioactive lipids are potent signaling molecules involved in both pro-inflammatory and resolution processes through receptor interactions. The formation and clearance of lipid signaling mediators are controlled by multiple metabolic enzymes. An imbalance of these lipids can result in exacerbated and sustained inflammatory processes which may result in pulmonary damage and disease. Dysregulation of pulmonary bioactive lipids contribute to inflammation and pulmonary toxicity following exposures. For example, inhalation of cigarette smoke induces activation of pro-inflammatory bioactive lipids such as sphingolipids, and ceramides contributing to chronic obstructive pulmonary disease. Additionally, exposure to silver nanoparticles causes dysregulation of inflammatory resolution lipids. As inflammation is a common consequence resulting from inhaled exposures and a component of numerous diseases it represents a broadly applicable target for therapeutic intervention. With new appreciation for bioactive lipids, technological advances to reliably identify and quantify lipids have occurred. In this review, we will summarize, integrate, and discuss findings from recent studies investigating the impact of inhaled exposures on pro-inflammatory and resolution lipids within the lung and their contribution to disease. Throughout the review current knowledge gaps in our understanding of bioactive lipids and their contribution to pulmonary effects of inhaled exposures will be presented. New methods being employed to detect and quantify disruption of pulmonary lipid levels following inhalation exposures will be highlighted. Lastly, we will describe how lipid dysregulation could potentially be addressed by therapeutic strategies to address inflammation.
The invention provides a traditional Chinese medicine composition with the functions of detoxification and vein relaxing, which is prepared from the following raw materials in parts by weight: 14-22 parts of giant knotweed, 14-22 parts of weeping forsythia, 20-40 parts of sedum sarmentosum, 14-22 parts of herba siegesbeckiae, 9-21 parts of suberect spatholobus stem, 9-21 parts of astragalus and 14-22 parts of szechuan lovage rhizome. The invention provides application of the traditional Chinese medicine composition. The advantages are that: the traditional Chinese medicine composition takes clearing heat toxin, removing blood stasis toxin, tonifying qi, activating blood and dredging collaterals as a treatment method, and can improve clinical symptoms of patients such as memory decline, cognitive degradation, anxiety depression, sleep disorder and the like related to cerebral arteriolar lesions. Cell experiments prove that the traditional Chinese medicine composition has a protective effect on human brain microvascular endothelial cell injury caused by hypoxia reoxygenation, and can inhibit apoptosis. Animal experiments prove that the traditional Chinese medicine composition has a protective effect on chronic ischemic injury of white matter. Therefore, the traditional Chinese medicine composition can be applied to the prevention and/or treatment of clinical symptoms related to cerebral small vessel lesions under the pathological mechanism of heat stasis and toxin accumulation.
Adequate long-term studies in animals to evaluate carcinogenic potential have not been conducted with fluorouracil. Studies with the active ingredient of fluorouracil, 5-fluorouracil, have shown positive effects in in vitro tests for mutagenicity and on impairment of fertility.5-Fluorouracil was positive in three in vitro cell neoplastic transformation assays. In the C3H/10T½ clone 8 mouse embryo cell system, the resulting morphologically transformed cells formed tumors when inoculated into immunosuppressed syngeneic mice.  
While no evidence for mutagenic activity was observed in the Ames test (three studies), fluorouracil has been shown to be mutagenic in the survival count rec-assay with Bacillus subtilis and in the Drosophila wing-hair spot test. Fluorouracil produced petite mutations in Saccharomyces cerevisiae and was positive in the micronucleus test (bone marrow cells of male mice).  
Fluorouracil was clastogenic in vitro (i.e., chromatid gaps, breaks, and exchanges) in Chinese hamster fibroblasts at concentrations of 1.0 and 2.0 mcg/mL and has been shown to increase sister chromatid exchange in vitro in human lymphocytes. In addition, 5-fluorouracil has been reported to produce an increase in numerical and structural chromosome aberrations in peripheral lymphocytes of patients treated with this product.  
Doses of 125 to 250 mg/kg, administered intraperitoneally, have been shown to induce chromosomal aberrations and changes in chromosome organization of spermatogonia in rats. Spermatogonial differentiation was also inhibited by fluorouracil, resulting in transient infertility. However, in studies with a strain of mouse which is sensitive to the induction of sperm head abnormalities after exposure to a range of chemical mutagens and carcinogens, fluorouracil was inactive at oral doses of 5 to 80 mg/kg/day. In female rats, fluorouracil administered intraperitoneally at doses of 25 and 50 mg/kg during the preovulatory phase of oogenesis significantly reduced the incidence of fertile matings, delayed the development of preimplantation and postimplantation embryos, increased the incidence of preimplantation lethality and induced chromosomal anomalies in these embryos. Single-dose intravenous and intraperitoneal injections of 5-fluorouracil have been reported to kill differentiated spermatogonia and spermatocytes (at 500 mg/kg) and to produce abnormalities in spermatids (at 50 mg/kg) in mice.
FIELD: biochemistry.SUBSTANCE: invention relates to production of iodized whey proteins for preparing a biologically active substance and can be used for preventing iodine deficiency disorders in humans and animals. Process of iodination of initial protein raw material, in form of α-lactalbumin, β-lactoglobulin or a mixture of said proteins, or hydrolysates of said proteins, by mixing with an aqueous solution of inorganic iodine at temperature of 20–40 °C and at ratio of solution of inorganic iodine to total protein selected (2–40):1. Mixture of whey proteins is fermented with an aqueous solution of inorganic iodine by adding a buffer mixture of reagents – a complex of NaCl mineral salts and Na and K phosphates and a mixture of lactoperoxidase-based enzymes containing 16–24 wt%, horseradish peroxidase and from 14 to 21 wt% of catalase. Buffer mixture contains 14–18 wt% sodium phosphate and 22–28 wt% potassium orthophosphate with stability pH=6–8 with a reaction mixture of enzymes immobilized on semi-permeable membranes or on inert carriers. Fermentation process is carried out with continuous monitoring of iodine content in the solution. Aqueous solution of iodinated proteins is purified from macroimpurities and microimpurities, including from inorganic iodine, using macrofiltration, microfiltration with subsequent diafiltration of aqueous solution of iodinated proteins on ultrafiltration unit in tangential flow mode using membrane modules with cut-off limit of 300 to 800 Da at pH 6.0–8.0. Obtained solution of iodated proteins subject to sterilizing microfiltration, then sublimation or spray drying to obtain a finished powder product with content of deterministic covalently bound iodine in amount of 0.5–4 % in form of a mixture of iodised amino acids – monoiodotyrosines in amount of 55–75 wt% in iodated proteins, 24.0–43.5 wt% di-iodotyrosines and 1.0–1.5 wt% of tri-iodotyrosines.EFFECT: invention enables to obtain a ready powder product with given content of deterministic amount of covalently bound iodine with optimal and specified content of iodised amino acids in it – monoiodotyrosines, di-iodotyrosines and tri-iodotyrosines, production of industrial volumes of iodized milk whey proteins.1 cl, 6 ex
One week of treatment with HC3 followed by 3 weeks of no treatment. The standard intensive consolidation chemotherapy course HC3 includes dexamethasone (10 mg/m\^2/day intravenous \[IV\] on Days 1-6), vincrisitne (1.5 mg/m\^2/day IV on Days 1 and 6), daunorubicin (30 mg/m\^2 IV over 24 hours on Day 5), methotrexate (1 g/m\^2 IV over 36 hours on Day 1), ifosfamide (800 mg/m\^2 IV for 1 hour on Days 2-4), and pegylated \[PEG\]-asparaginase (1000 U/m\^2 IV for 2 hours or intramuscularly \[IM\] on Day 6) or, if allergic, erwinia-asparaginase (20,000 units/m\^2 IV or IM every 48 hours for a total of 6 doses).
The present invention relates to an infrared radiation cosmetic composition, and infrared radiation cosmetics comprising same. The present invention relates to infrared radiation cosmetics in which infrared rays of the cosmetics having an infrared radiation function permeates deeply into the skin to activate the function of cells and cause vasodilatation of the capillary vessels, thus promoting blood circulation and cell tissue genesis. The present invention relates to a cosmetic composition having an infrared radiation function, comprising silicon dioxide(SiO 2 ), aluminum oxide(Al 2 O 3 ), and ferric oxide(Fe 2 O 3 ) which are mixed at a specific mixing ratio. The present invention also relates to infrared radiation cosmetics using said cosmetic composition. More particularly, the present invention provides infrared radiation cosmetics which radiate 80 to 95% of infrared rays of 5 to 20 wavelengths and which have radiation energy of 3.0×10 2  to 4.0×10 2  (W/m 2 .µm, 37̊C). The infrared radiation cosmetics of the present invention cause infrared rays to permeate the skin in order to prevent or delay skin ageing and promote metabolism using an advantageous function of the infrared ray.
Lipophilic compositions comprise a fat-soluble vitamin, a lipophilic derivative of a water-soluble vitamin, a carotenoid or any mixture of these, in admixture with a non-ionic emulsifier and an ionic wetting agent.  The compositions may be mixed with water, or aqueous solutions of polyalcohols and/or hydrocolloids to give clear stable solutions.  Vitamins may be A, D, E, K1, or lipophilic derivatives of water-soluble vitamins such as pantothenol cetyl ether, or pyridoxin tri-palmitate, or carotenoids.  Preferred non-ionic emulsifiers are those containing polyoxyethylene groups; ionic wetting agents may be anionic, cationic, or amphateric, many being listed. Water-soluble vitamins, e.g. Vitamins C, B1, B2, B6, and nicotinamide, sugars, e.g. sucrose, sorbitol, glucose, invert sugar, and also starch syrup or glycerine are mentioned as the aforesaid polyalcohols, and hydrocolloids may be methyl cellulose, tragacanth, polyvinylpyrrolidone, polyvinyl alcohol, pectin, and/or guar gum. Examples are given for preparations containing many fat-soluble vitamin mixtures, which are then admixed with aqueous solutions which may contain water-soluble vitamins.