anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Exploring the predictive value of NLR, PLR, MLR, and SII for the severity of cervical cancer screening abnormalities in patients.
METHODS: A retrospective analysis was conducted on the data of 324 patients suspected of cervical lesions due to abnormal TCT and/or HPV in our hospital from January 2023 to December 2023, who underwent colposcopy. The pathological results of colposcopic biopsy confirmed that there were 140 cases of chronic cervicitis, which classified as the group without cervical lesions. The cervical lesion group included 184 cases, including 91 cases of LSIL, 71 cases of HSIL, and 22 cases of cervical cancer. Compared the differences in preoperative peripheral blood NLR, PLR, MLR, and SII among different groups of patients, and evaluated their predictive value for the severity of cervical lesions using Receiver Operating Characteristic (ROC) curves.
RESULTS: The levels of NLR, PLR, and SII in the group without cervical lesions were lower than those in the group with cervical lesions (p < 0.05), and there was no statistically significant difference in MLR (p > 0.05). The comparison of NLR among LSIL, HSIL, and cervical cancer groups showed statistically significant differences (p < 0.05), while PLR, MLR, and SII showed no statistically significant differences (p > 0.05). The AUC of peripheral blood NLR, PLR, and SII for predicting cervical lesions were 0.569, 0.582, and 0.572, respectively. The optimal cutoff values were 2.3,176.48, and 603.56. The sensitivity and specificity were 38.6% and 73.6%, 28.8% and 85.7%, 37.5% and 76.4%, respectively. At the same time, the joint testing of the three had the highest efficiency, with sensitivity of 69% and specificity of 45%.
CONCLUSION: Although the peripheral blood NLR, PLR, and SII of the cervical lesions patients were higher than those without cervical lesions in cervical cancer screening abnormal patients, the predictive ROC curve discrimination was low. Therefore, it is not recommended to use preoperative peripheral blood inflammatory markers as markers for cervical cancer screening abnormal patient diversion.
Electrical acupuncture, tDCS, and NDT-BOBATH rehabilitation were performed for 30 minutes per time, respectively. The number of intervention was held for about a month, five times a week(a total of 20 times).
The intervention group consists of 30 patients diagnosed with PTSD induced by ACS. Eight individual EMDR sessions lasting for 1 hours will be provided over 8 weeks by licensed EMDR therapists from the German-speaking part of Switzerland. Each EMDR session follows a standardized 8-phase protocol.
The investigators will conduct a 12-month, multicenter, randomized controlled trial among 250 African-American Veterans with gout with a ULT medication possession ratio of \<80% at Birmingham, St. Louis, and Philadelphia VA clinics. The investigators will compare the efficacy of the storytelling intervention to usual care in improving Urate Lowering Therapy (ULT) adherence, assessed with MEMSCaps (electronic monitoring) at 6-months (primary outcome); reducing gout flares needing treatment, improving patient satisfaction, improving the ability to achieve target serum urate \<6 mg/dl and improving self-reported ULT adherence at 6-months (secondary outcomes). The investigators will assess these outcomes at 12-months as evidence for the sustenance of the effect of the intervention.

Alignment with VA mission and priorities: This study serves the VA's mission of improving the health of Veterans and addresses two priority areas, 1) decreasing health care disparities and 2) improving health care delivery using a low-cost, technology-based solution to poor medication adherence. Study results will lead to a ready-to-implement low-cost patient-centered intervention for AA Veterans with gout to improve medication adherence and patient outcomes. This study will provide proof of the efficacy of "storytelling" for improving medication adherence in chronic symptomatic diseases. The "storytelling" intervention can be easily adapted for similar chronic symptomatic conditions such as COPD and CHF.
PURPOSE:To obtain a healthy nutriment, containing Gynostemma pentaphyllum Makino and Houttuynia cordata Thunb. as materials and useful for preserving health and maintaining physical strength. CONSTITUTION:A healthy nutriment obtained by drying whole folk medicinal herbs, such as Gynostemma pentaphyllum Makino and Houttuynia cordata Thunb. and powdering the dried herbs. The Houttuynia cordata Thunb. is used in an amount of 1.5 times based on the Gynostemma pentaphyllum Makino and powdered as finely as possible. The resultant powder is subsequently used as a culture medium required for fermenting yeast fungi and water and saccharides are added to provide a culture medium. Yeast fungal spawns are then inoculated to keep the obtained culture medium at 37-38 deg.C and propagate the yeast fungi. A wheat bran KOJI (yeast) is subsequently blended to carry out brewing and aging and the resultant substance is dried. A lactic acid solution obtained by fermenting lactic acid bacteria is then added thereto, stirred and permeated to afford the objective substance. Collective effects of the Gynostemma pentaphyllum Makino and Houttuynia cordata Thunb. can be combined with effects of the yeast fungi to provide universal combined effects.
A pharmaceutical composition for the treatment of periodontal and other diseases comprises zinc chloride, the active ingredients of sanguinaria and galangal, and purified water as an excipient. Preferred proportions of the constituents are, by weight: zinc chloride 45% sanguinaria 10.8% galangal 7.2% water 37%. These proportions produce a paste, and an excipient such as petroleum jelly may be added in such a proportion as to produce an ointment. Dilution may be effected by the addition of distilled water or gelatin, and a quantity of the order of 2%, by weight, of sodium carboxy-methyl cellulose may be added as a drying agent. The pharmaceutical composition may be administered externally, as a paste or ointment, or may be provided in capsules, with gelatin crystals as a buffer, to be taken orally, or may be administered parenterally. The pharmaceutical composition can be prepared by dissolving zinc chloride in purified water, screening and mixing sanguinaria and galangal and adding the zinc chloride solution to the mixture of sanguinaria and galangal to produce the paste.
Several common genetic variants have been reliably associated with type 2 diabetes and related glycemic traits. Study investigators hypothesize that variants in genes that are reproducibly associated with type 2 diabetes or related glycemic traits may impact the effect of anti-diabetic medications. In particular, sulfonylureas may have differential effects on individuals depending on the allelic variant they carry at KCNJ11 E23K; conversely, because TCF7L2 is postulated to influence insulin secretion by regulating the action of glucagon-like peptide 1 (GLP-1), and sulfonylureas act at a different step in the insulin secretion pathway, the effect of sulfonylureas on insulin secretion could be independent of genetic variation at TCF7L2. In addition, physiological responses to an insulin secretagogue or an insulin sensitizer may shed light on the mechanism of action of reported genetic associations.

Despite the convincing associations of several genetic variants with type 2 diabetes and their involvement in physiological pathways involved in drug response, their impact on pharmacological interventions has not been systematically examined. The completion of the Human Genome Project and the high-density characterization of common human variation in four different ethnic groups highlight the promise of genomic medicine. The elucidation of the genetic architecture of complex phenotypes may help clinicians understand disease heterogeneity, uncover new pathophysiological mechanisms, open the opportunity for novel therapeutic interventions, provide predictive diagnostic and prognostic information, and allow for individually tailored therapy that takes into account both the probability of response and the incidence of drug-induced complications.
The invention relates to the chemistry of organic heterocyclic compounds, and specifically to a new compound based on pyroxidine, of formula (1). The claimed compound shows a high level of antiepileptic activity. At doses of 25, 50 and 100 mg/kg, the compound (1) completely suppresses epileptic electrical activity in the brain within an hour of intraperitoneal administration to rats in the penicillin-induced epilepsy model. In the pentylenetetrazole-induced epilepsy model on rates, the compound (1) decreased seizure intensity and duration when administered in intraperitoneal doses of 25 and 100 mg/kg and oral doses of 100 and 200 mg/kg, and completely prevented seizures in individual cases when administered orally in a dose of 250 mg/kg. Moreover, the compound (1) has low toxicity since the LD50 parameter in rats is over 2000 and 5000 mg/kg of body weight for intraperitoneal and oral administration, respectively. Overall, the claimed technical solution enables the creation of a new, safe and highly effective medicinal preparation for the treatment of epilepsy which has the potential to substantially improve patient quality of life and lifespan.
PROBLEM TO BE SOLVED: To industrially obtain a cod liver oil having a specific peroxide value and a specified aldehyde value, scarcely generating a smell and having excellent stability. SOLUTION: This cod liver oil has a peroxide value of <=5 meq/kg and an aldehyde value of <=0.020 mmol/g. The cod liver oil is obtained by subjecting cod liver oil to a peroxide-removing treatment, adding 0.01-1 pt. of one or more antioxidizing agents selected from the group consisting of dibutylhydroxytoluene, butylhydroxyanisole, citric acid, ascorbic acid and their esters to 100 pts. of the treated cod liver oil, and subsequently subjecting the mixture to a deodorization treatment using a thin film distillation device at a deodorization temperature of 80-120 deg.C under a vacuum degree of <=2 mmHg. The retention time of the cod liver oil is preferably 2-20 sec.  The peroxide-removing treatment is carried out by adding an adsorption treatment agent such Japanese acid white clay or activated white clay preferably in an amount of 0.5-10 pts.wt. to 100 pts.wt. of the cod liver oil, further adding a filtration auxiliary preferably in an amount of 50-100 wt.% based on the adsorption treatment agent and subsequently filtering the treated mixture.
PURPOSE:To eliminate blur to attain an encoding system of high reproducibility by preliminarily subjecting a picture to be encoded to filtering processing to generate a high band-emphasized picture. CONSTITUTION:A roentgenogram is digitized by a film digitizer 50 or the like and is inputted, and an original picture 20 taken into a processor 51 is subjected to filtering processing to generate the high band-emphasized picture. This picture is thinned and reduced by a block size, and a reduction picture 21 is enlarged by two-dimensional line forecasting to generate a forecasted picture 22, and a forecasted error 23 between the forecasted picture 22 and the original picture 20 is calculated. An encoding mode 24 is selected for each block in accordance with the forecasted error 23 to encode the picture. Encoded data stored in an external storage device 52 is decoded and is displayed on a display device 53 or a photo printer 54. Thus, the occurrence of blue in edge parts, minute structure parts, or the like is prevented.
Participants receive Flexiquit, an avatar-led computerized smoking cessation program. Flexiquit is a self-delivered app providing: motivational interviewing, psychoeducation on addiction/withdrawal, cognitive-behavioral strategies for cravings, relapse prevention, stress/emotion regulation skills. Delivered over 6 months starting Day 2 after initial assessments. Adherence monitored. Biochemical verification of abstinence at 3 and 6 months post-quit.
BACKGROUND: The present research aims to investigate the clinical diagnostic value of LncRNA HOXA distal transcript antisense RNA (HOTTIP) in acute respiratory distress syndrome (ARDS) of sepsis and its predictive significance for mortality.
METHODS: One hundred eighteenth patients with sepsis and 96 healthy individuals were enrolled. RT-qPCR to examine HOTTIP levels. The incidence of ARDS and death was recorded. The diagnostic significance of HOTTIP in sepsis ARDS was examined using ROC and logistic regression analysis. The correlation between HOTTIP and disease severity was evaluated using Pearson's coefficients. Kaplan-Meier analysis and COX regression were employed to examine the predictive significance of mortality. Validation of HOTTIP target miRNA by dual-luciferase assay.
RESULTS: HOTTIP was persistently up-regulated in patients with ARDS sepsis than in patients without ARDS patients (P < 0.05). HOTTIP was a risk factor for the development of ARDS, which could be diagnosed in ARDS patients from non-ARDS patients (AUC = 0.847). Both the SOFA score (r = 0.6793) and the APACHE II score (r = 0.6384) were positively correlated with the HOTTIP levels. Furthermore, serum HOTTIP was an independent predictor of short-term mortality (HR = 4.813. 95%CI: 1.471-15.750, P = 0.009) and noticeably predicted the occurrence of short-term death (log rank = 0.020). miR-574-5p, a target miRNA for HOTTIP, was reduced in patients with sepsis ARDS and negatively correlated with HOTTIP.
CONCLUSIONS: The presence of HOTTIP serves as a diagnostic biomarker for the occurrence of ARDS, exhibits correlation with disease severity, and provides predictive value of short-term mortality in sepsis patients. HOTTIP may be involved in ARDS progression by targeting miR-574-5p.
PURPOSE:To obtain a perfume composition which can be incorporated into foods and drinks, cosmetics, drugs for health and sanitation, etc., to impart thereto various flavor and taste characteristics like, e.g. cone and cooked rice, by using a 1-pyrroline as constituent. CONSTITUTION:A 1-pyrroline of the formula (wherein R is H or 1-3C alkyl) (e.g. 1-pyrroline, 2-methyl-1-pyrroline or 2-isopropyl-1-pyrroline) is used as effective constituent to give a perfume composition. The compound of the formula has flavor and taste characteristics like cone, cooked rice, a sugar cane, an egg, chicken, pineapple, tropical fruits, ozone, green, and marine with very excellent persistence. An example of its content is about 0.001-30wt.% based on the total weight of the composition. The composition can be incorporated into various foods and drinks, cosmetics, drugs, etc.
The inventive method for producing an antineoplastic based on tetra-chloro-platinite of potassium consists in treating a water solution containing humic substances with a solution of tetra-chloro-platinite of potassium. Said treatment is carried out by exposing to the action of ultrasound having a radiation power of 40 W/cm2 and a frequency of 22 Hz during 4-8 minutes. The humic substances can be exuded by treating a humified material with an alkaline solution at standard conditions. Moss peat and transition peat, or composts, or sapropels, or the humus horizons of various soils can be used as the humified material. The humic substances can be also produced from oxidised wood lignin. It is rational to produce humic acids by oxidising the wood lignin in an alkaline medium with the aid of an oxygen-containing gas at a temperature of 170 20 °C, a pressure ranging from 1.9 to 2.5 MPa during a time period ranging from 1 to 3 hours, aftercooling the stock, separating a solid phase from the solution and acidulating it till pH =2-3 is obtained.
The present invention relates to a use of Hsian-tsao ( Mesona procumbens  Hemsl.) extracts for preparing a pharmaceutical composition for promoting wound healing. The extracts according to the present invention, e.g. ethanol extracts of Hsian-tsao or polysaccharides from water extracts of Hsian-tsao, can regulate wound healing related factors and thus enhance wound healing. As such, the Hsian-tsao ( Mesona procumbens  Hemsl.) extracts can be applied to improve the diabetic wound healing and decrease the risk of infection.
FIELD: medicine, narcology. SUBSTANCE: innovation deals with elaborating preparations against pathological addiction and abstinence syndrome in case of opium narcomania. For increasing the number of curative preparations the following peptide compound CP - Arg-Pro-Lys-Pro-Gln- Gln-Phe-Gly-Leu-Met-NH2 of low therapeutic properties should be used in composition with AntiCP - Arg-Pro- Lys-Pro-Gln-Gln-Phe-Phe-D-Pro-(spiro-gammalactam)- Trp-NH2. The innovation enables to considerably increase efficiency in treating opium narcomania. EFFECT: higher efficiency of therapy. 3 dwg, 3 ex
The present invention relates to a preparation for treating rhinitis. A recipe of the present invention comprises astragalus roots, xanthium (fry), scorched white atractylodes rhizomes, ledebouriella roots, dahurian angelica roots, asarum, centipeda herbs, wild chrysanthemums, grassleaved sweetflag rhizomes, chuanxiong rhizomes, magnolia flowers, yam rhizomes, cuttle bones, Chinese ephedra, cassia twigs, calcined os draconis, oysters, chlorpheniramine maleate and hydrochloric acid racanisodamine, wherein the magnolia flowers, the asarum, the chlorpheniramine maleate and the hydrochloric acid racanisodamine are taken and crushed into 100 meshes of fine powder. The astragalus roots, etc. are taken and decocted twice in water. Ten times of amount of water is added for the first time, and the Chinese drugs are decocted for 1.5 hours; eight times of amount of water is added for the second time, and the Chinese drugs are decocted for 1.5 hour, filtered and combined into filter liquid which is decompressed and concentrated into paste. Fine powder is obtained through spray drying, dextrin is added, and the fine powder of the magnolia flowers, the asarum, the chlorpheniramine maleate and the hydrochloric acid racanisodamine is added for mixing to be uniformly mixed so as to be extruded into granules. The present invention is obtained through granule correction, split charging, packaging and sterilization. The present invention has the advantage of safety, and rapidly takes effect. The present invention is suitable for most crowds, and has the functions of invigorating the lung, benefiting qi, dispersing wind and promoting the restoration of consciousness.
The investigators plan to accomplish this objective by developing, implementing, and evaluating a randomized controlled trial of an intervention to improve diet and physical activity-related risk factors of obesity. A previous iteration of the intervention trial, called Obesity Prevention Research and Evaluation of InterVention Effectiveness in NaTive North Americans (OPREVENT) was implemented in five American Indian communities in Michigan and New Mexico. OPREVENT was a multi-level, multi-component intervention functioning at the community, institution, household, and individual levels and was implemented in schools, food stores, and worksites. Prior to OPREVENT, the research team has run multi-level interventions by working with schools and food stores in Native North American (NNA) communities1-6. For this new trial, named OPREVENT2, the research team will expand on the collective experience working on obesity prevention interventions in American Indian (AI) settings by developing complementary policy and social media components to support long-term sustainability of the OPREVENT intervention. OPREVENT2 will be implemented in six new AI communities.
OBJECTIVE: "Stop stunting" is the central focus of the national Indonesian campaign to improve child health. We provide an autoethnographic statement on the currently practiced strategy that commits 23 ministries and an estimated $3.9 billion per year to coordinating nutrition interventions that are supposed to address the underlying causes of stunting.
METHODS: We visited six community health posts (posyandus) in West Timor and in Java and participated in routine child health examinations. We documented our impressions and discussed them with Indonesian colleagues, health officials, and local physicians.
RESULTS: Routine health checks for children include anthropometry (height, weight, head, and mid-upper arm circumference), immunizations, and documentation in the children's health records. The examinations do not include a physical examination, vision and hearing tests of the child, health questionnaires, or information on nutrition. No specific information or recommendations are given to the mothers.
CONCLUSION: Stunting is highly prevalent in Indonesia and "Stop-stunting" campaigns have become a national issue. Yet, their impact is disillusioning. Stunting is associated with a way of life that differs from that in developed Western countries today and was prevalent in feudal and other nondemocratic societies. We do not want to throw away policies that try to improve growth in children, but instead of spending money for dubious interventions as we have encountered in Indonesia, we rather suggest spending thoughts on the political and emotional causes of poor growth in otherwise healthy Indonesian children.
OBJECTIVES: Understanding adolescent perspectives on prescribed opioids in the context of medical care for acute pain is needed to prevent opioid-related adverse outcomes. We explored factors that may influence opioid decision-making and use behaviors among adolescents prescribed opioids for acute pain.
METHODS: We conducted semistructured interviews with 19 adolescents (63% females, ages 12 to 17) prescribed opioids upon discharge from surgery or intensive care unit admission. Interview transcripts were coded using inductive thematic analysis.
RESULTS: Five themes were identified: "Opioid use to reduce extreme pain and facilitate acute recovery"; "Familiarity with risks and negative effects of opioids"; "Assessment of opioid risk based on individual characteristics and use behaviors"; "Careful balance of risks, benefits, and symptoms when taking opioids"; "Importance of trusted adults for adolescent opioid management". Adolescents commonly believe opioids are only appropriate for severe pain that cannot be managed with other strategies. Most (but not all) adolescents were aware of addiction and other potential opioid harms and generally disapproved of misuse. However, a few adolescents would consider taking unprescribed opioids for severe pain. Adolescents wanted to be well informed for opioid decision-making, considering guidance from trusted adults.
DISCUSSION: Adolescents often demonstrated active and sound participation in shared opioid decision-making, influenced by complex integration of inputs and self-reflection. Conversely, potential factors that could contribute to risky behaviors included low personal risk perceptions, uncertainty about what constitutes opioid misuse, and avoidance of prescribed opioids despite extreme pain. Future studies may explore associations of adolescents' opioid decision-making with longer-term pain and opioid-related outcomes.