anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: There is growing evidence supporting the role of inflammatory mechanisms in complex regional pain syndrome (CRPS). Corticoids, as most effective anti-inflammatory drugs, are widely used in treating inflammation. The aim of this study was to retrospectively assess the efficacy of oral corticoid treatment in CRPS patients.
METHODS: Patients treated at the center of pain medicine in the Erasmus University Medical Centre between January 2015 and January 2020 were approached to partake in this study. Medical records were screened for age, gender, medical history, duration of CRPS, and CRPS severity score. Also, treatment effect, dose and duration, pain scores (NRS), and side effects were extracted from medical records. In addition, global perceived effect was completed in patients treated with corticoids.
RESULTS: Between January 2015 and January 2020, twenty-nine CRPS patients received corticoids and met the inclusion criteria. One extreme outlier was excluded and treatment effect was unknown for one patient. Average daily dose was 28.9 mg (range 10-30 mg) and the mean treatment duration was 10.5 days (7-21 days). Fourteen patients (51.9%) responded positively to treatment and thirteen (48.1%) did not respond. Side effects were reported in five patients (17.9%).
CONCLUSIONS: Corticoid treatment was effective in more than half of the patients. With only mild side effects reported the treatment also appears to be relatively safe. Further research is needed to investigate the efficacy of corticoids in treating (early) CRPS, preferably in an intervention study.
Sepsis is a life-threatening inflammatory condition partly orchestrated by the release of various damage-associated molecular patterns such as extracellular cold-inducible RNA-binding protein (eCIRP). Despite advances in understanding the pathogenic role of eCIRP in inflammatory diseases, novel therapeutic strategies to prevent its excessive inflammatory response are lacking. Milk fat globule-epidermal growth factor-VIII (MFG-E8) is critical for the opsonic clearance of apoptotic cells, but its potential involvement in the removal of eCIRP was previously unknown. Here, we report that MFG-E8 can strongly bind eCIRP to facilitate αvβ3-integrin-dependent internalization and lysosome-dependent degradation of MFG-E8/eCIRP complexes, thereby attenuating excessive inflammation. Genetic disruption of MFG-E8 expression exaggerated sepsis-induced systemic accumulation of eCIRP and other cytokines, and consequently exacerbated sepsis-associated acute lung injury. In contrast, MFG-E8-derived oligopeptide recapitulated its eCIRP binding properties, and significantly attenuated eCIRP-induced inflammation to confer protection against sepsis. Our findings suggest a novel therapeutic approach to attenuate eCIRP-induced inflammation to improve outcomes of lethal sepsis.
The derivation cohort will correspond to approximately 70% of the total sample to be analyzed in the study. The Ex-Care II risk model will build upon it. It is composed of patients operated in the participating institutions.
1,216,372. Anthelmintic compositions and methods. MONSANTO CO. 9 Jan., 1968, No. 1267/68. Headings A5B and A5E. An anthelmintic composition comprises, as active ingredient, a compound of formula wherein Z is a nitroalkyl or haloalkenyl group having 1-8 carbon atoms or a nitroaryl, haloalkaryl or haloaralkyl group having up to 18 carbon atoms, X is Cl or Br and n is 0 or an integer from 1-5, and a granular solid diluent. The invention also comprises a method of controlling Nemathelminthes and Platyhelminthes (otherwise than in a human being) by exposing them to an effective amount of the active ingredient, e.g. in a solid or liquid composition. The composition may be in the form of an animal feed.
On the day of the lavender group, after filling the first phase questionnaire, 20 drops of the lavender oil will be added to the electrical aromatherapy vaporizer near the patient's chair at a distance of 20 cm in the waiting room. After 20 minutes, the second phase questionnaire will be given to the patient, and then the patient will be transformed to dental clinics in which the lavender vaporizer will be placed near the dental unit at a distance of 20 cm. The vaporizer will be also prepared by adding 20 drops of the lavender which will be added added every 20 minutes until the dental sitting will be finalized, and the third questionnaire will be answered. At home, the patients will be asked to pour 3 drops of the lavender on a pad and inhale it for 5 minutes from 10 cm distance every one hour until they attend on the next day to answer the fourth questionnaire.
The invention discloses a 7 site-connected bis(beta-carboline alkaloid) compound and its preparation method, pharmaceutical composition and use. The bis(beta-carboline alkaloid) compound and its medicinal salt are shown in the general formula I. The bis(beta-carboline alkaloid) compound is prepared by condensation of a beta-carboline intermediate and dihalogenated alkane. The invention discloses a pharmaceutical composition. The pharmaceutical composition comprises an effective dose of the bis(beta-carboline alkaloid) compound shown in the formula I and pharmaceutically acceptable carriers. The invention relates to a use of the bis(beta-carboline alkaloid) compound in preparation of drugs for resisting cancers such as melanoma, stomach cancer, lung cancer, breast cancer, kidney cancer, liver cancer, human oral epidermoid carcinoma, cervical carcinoma, ovarian cancer, pancreas cancer, prostate cancer and colorectal carcinoma.
<P>PROBLEM TO BE SOLVED: To provide a medical report preparation support system reducing oversight of added findings.  <P>SOLUTION: The report preparation support system adds a second finding different from a first finding to a medical report into which the first finding has been input. A finding addition button 71 is arranged on an editing picture 62, and when the finding addition button 71 is clicked, an input column 72 for adding the second finding is displayed apart from an input column 63 into which the first finding has been input. The medical report is read out to the editing picture 62 in a state where editing of the input column 63 for the first finding is inhibited. In the medical report, the second finding and the first finding are displayed on a display screen in an equivalent size.  <P>COPYRIGHT: (C)2010,JPO&INPIT
In this study everolimus will be administered in combination with exemestane, which is an irreversible steroidal aromatase inactivator that has demonstrated efficacy in the treatment of postmenopausal patients with ABC. Exemestane is indicated for adjuvant treatment of postmenopausal women with HR+ EBC who have received two to three years of tamoxifen and are switched to exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy. It is also indicated for the treatment of ABC in postmenopausal women whose disease has progressed following tamoxifen therapy (in the USA) or following antiestrogen therapy (in Europe). In 2011, the BOLERO-2 trial reported (5; 33) a significant benefit for HR+ HER2- postmenopausal pretreated women in the ABC setting by combining everolimus with exemestane. In this randomized, double-blind, placebo-controlled trial a statistically significant improvement in PFS by adding everolimus to exemestane versus exemestane alone was reported. Adding everolimus determined a 2.4-fold prolongation in PFS from 3.2 up to 7.4 months and so lowered the risk of cancer progression by 56% for these women. These findings were confirmed by an independent assessment (4.1 vs. 11.0 months, risk reduction: 64%). The QoL data shows positive trend in the everolimus plus exemestane treatment arm.
OBJECTIVES: The goal of this quality improvement project (QIP) was to increase awareness of the serious medical consequences of clozapine-associated constipation to front line nursing staff and patients with schizophrenia.
METHODS: The QIP was developed iteratively by psychiatric nurses, psychiatrists and pharmacists with input from patients. The processes involved a literature review, development of educational materials for staff and patients, and the creation of a daily bowel movements log (BML). Implementation involved review of the BML at treatment team meetings, and deployment of pharmacological and non-pharmacological interventions to resolve constipation and increase awareness and knowledge of this clinical concern.
OUTCOMES: The initial pilot screened for symptoms of constipation in patients receiving clozapine and non-clozapine antipsychotic agents and intervening as necessary during multidisciplinary team meetings. Patients benefited from relief of constipation and improved bowel habits. Staff benefited from improved knowledge and making requisite changes in workflow and practice. Feedback allowed refinements to be made to the educational materials for patients and staff. Since full implementation, bowel habits are routinely monitored, and interventions are reviewed for effectiveness. Staff satisfaction with this QIP is reflected in answers to a structured questionnaire and in patient reports (n = 50).
CONCLUSIONS: Clozapine, the only approved and efficacious medication for treatment-resistant schizophrenia is significantly underutilized. Medically consequential constipation can be a serious barrier to retention of patients benefiting from clozapine. Increased awareness and use of educational materials for patients and staff, routine monitoring of bowel habits combined with pharmacological and non-pharmacological interventions can successfully address this clinical problem.
EP395 in repeated doses. Oral, once-daily administration of 3 EP395 capsules for 12 weeks.
Pain is usually seen in the scapular region in patients with fibromyalgia. We decided to do this study because we thought that there was no exercise for this area before in our study and that if it was done, improvements in pain and posture could be observed. Our study was conducted to investigate the effect of scapular stabilization exercise training on cervical posture and pain in fibromyalgia. 59 patients aged 18-60 years were included in the study. The patients included in the study were diagnosed with fibromyalgia from the physical therapy outpatient clinic and individuals who did not have any other disease were included. The included individuals were divided into 2 groups by randomization method. Individuals were divided into scapula exercise therapy group (n=29) and classical exercise therapy group (n=30). Hotpack, tens and ultrasound applications were applied to both groups as conventional treatment before exercise. This protocol was applied to both groups for 6 weeks, 5 days a week. Following this protocol, classical shoulder exercises (wand exercises, codman exercises and stretching exercises) were given to the classical group, and stabilization exercises (push-up exercises on the wall, scapular adduction, scapular elevation, rowing exercises) were given to the scapular stabilization group. While the study designer applied the treatment, another designer applied the evaluation. The patients were evaluated for pain, cervical posture, functional status, and quality of life. pain was evaluated with a visual analog scale (vas), cervical posture was evaluated by tragus-wall distance, functional status was evaluated with fibromyalgia impact questionnaire and quality of life was evaluated with nottingam quality of life questionnaire. All evaluations were performed twice before and at the end of the treatment (6 weeks).
Psychiatric Adverse Reactions

Fluoroquinolones, including ciprofloxacin, have been associated with an increased risk of psychiatric adverse reactions, including: toxic psychosis, psychotic reactions progressing to suicidal ideations/thoughts, hallucinations, or paranoia; depression, or self-injurious behavior such as attempted or completed suicide; anxiety, agitation, or nervousness; confusion, delirium, disorientation, or disturbances in attention; insomnia or nightmares; memory impairment. These reactions may occur following the first dose. Advise patients receiving ciprofloxacin to inform their healthcare provider immediately if these reactions occur, discontinue the drug, and institute appropriate care. 

Central Nervous System Adverse Reactions

Fluoroquinolones, including ciprofloxacin, have been associated with an increased risk of seizures (convulsions), increased intracranial pressure (pseudotumor cerebri), dizziness, and tremors. Ciprofloxacin, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold. Cases of status epilepticus have been reported. As with all fluoroquinolones, use ciprofloxacin with caution in epileptic patients and patients with known or suspected CNS disorders that may predispose to seizures or lower the seizure threshold (for example, severe cerebral arteriosclerosis, previous history of convulsion, reduced cerebral blood flow, altered brain structure, or stroke), or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold (for example, certain drug therapy, renal dysfunction). If seizures occur, discontinue ciprofloxacin and institute appropriate care [see Adverse Reactions(6.1) and Drug Interactions(7)].
Trivalent chromium (Cr(III)) is sometimes taken as a long-term supplement, but its effectiveness is unclear. Recently, Cr(III) reportedly modulates peroxisome proliferator-activated receptor gamma (PPARγ) expression. Our previous study reported that increased PPARγ after 24 h Cr(III) treatment promoted erythropoietin (EPO) production in HepG2 cells. In the current study, we analyzed 4-week Cr(III) treatment effects on PPARγ and EPO production in HepG2 cells. Long-term Cr(III) treatment resulted in significantly elevated mRNA expression levels of PPARγ and EPO compared to controls. Additionally, treatment with a PPARγ inhibitor suppressed EPO mRNA expression. Increased EPO mRNA expression due to stimulation with hypoxia or cobalt was unaffected by long-term Cr(III) treatment. Administration of lipopolysaccharide and pyocyanin which causes oxidative stress, promoted EPO production, but this effect was attenuated in cells treated with Cr(III). Long-term Cr(III) treatment increased hypoxia inducible factor (HIF)-1α and 2α mRNA expression and protein levels. Increased PPARγ, induced by long-term Cr(III) treatment, suppressed sirtuin1 (SIRT1) mRNA expression and increased EPO mRNA expression, suggesting that increased PPARγ attenuated the suppressive effect of SIRT1 on HIF. These results suggest that the sustained increase in PPARγ during long-term Cr(III) treatment maintains increased EPO production through a mechanism different from that observed under hypoxia.
PROBLEM TO BE SOLVED: To prepare an external preparation for the skin, having melanin production-inhibiting action, excellent in bleaching effect and capable of providing cosmetics excellent in stability and safety by including an extract from plants belonging to Passiflora. SOLUTION: This external preparation for the skin, capable of being used as cosmetics is prepared by including (A) an extract from plants belonging to Passiflora and, if needed, (B) an aqueous ingredient, an oil ingredient, a plant extract, an animal extract, powder, an surfactant, lubricant, an alcohol, coloring matter, perfumery or the like. Extract from Passiflora incarnata L. is preferably adopted as the ingredient A. The ingredient A is included in a quantity of 0.0001-20.0 wt.% (more preferably 0.01-5.0 wt.%) in terms of residue on evaporation to dryness. The ingredient A is prepared e.g. by extraction with a solvent such as water, ethyl alcohol or 1,3-butylene glycol under heating after starting the extraction at a lower temperature.
BACKGROUND: Powdery mildew (PM) is one of the important soybean diseases, and host resistance could practically contribute to soybean PM management. To date, only the Rmd locus on chromosome (Chr) 16 was identified through traditional QTL mapping and GWAS, and it remains unclear if the bulk segregant RNA-Seq (BSR-Seq) methodology is feasible to explore additional PM resistance that might exist in other varieties.
RESULTS: BSR-Seq was applied to contrast genotypes and gene expressions between the resistant bulk (R bulk) and the susceptible bulk (S bulk), as well as the parents. The ∆(SNP-index) and G' value identified several QTL and significant SNPs/Indels on Chr06, Chr15, and Chr16. Differentially expressed genes (DEGs) located within these QTL were identified using HISAT2 and Kallisto, and allele-specific primers (AS-primers) were designed to validate the accuracy of phenotypic prediction. While the AS-primers on Chr06 or Chr15 cannot distinguish the resistant and susceptible phenotypes, AS-primers on Chr16 exhibited 82% accuracy prediction with an additive effect, similar to the SSR marker Satt431.
CONCLUSIONS: Evaluation of additional AS-primers in the linkage disequilibrium (LD) block on Chr16 further confirmed the resistant locus, derived from the resistant parental variety 'Kaohsiung 11' ('KS11'), not only overlaps with the Rmd locus with unique up-regulated LRR genes (Glyma.16G213700 and Glyma.16G215100), but also harbors a down-regulated MLO gene (Glyma.16G145600). Accordingly, this study exemplified the feasibility of BSR-Seq in studying biotrophic disease resistance in soybean, and showed the genetic makeup of soybean variety 'KS11' comprising the Rmd locus and one MLO gene.
Participants in this arm will not receive any intervention for two weeks. Participants will complete the treatment after 4-6 weeks of being on the waitlist after their intake session.
The invention discloses a traditional Chinese medicine liniment for treating neuralgia, which comprises 26% of edible alcohol. The Chinese medicinal liniment also comprises 6.8 to 8.4 weight parts of dragon's blood. The Chinese medicinal liniment also comprises asarum, wherein the asarum accounts for 4.3-5.3 wt%. The Chinese medicinal liniment also comprises ligusticum wallichii, which accounts for 6.5 to 8.5 weight percent. The traditional Chinese medicine liniment also comprises 5 to 7 weight percent of safflower. The Chinese medicinal liniment also comprises pepper, and the pepper accounts for 3.4-4.2% of the total weight of the Chinese medicinal liniment. The Chinese medicinal liniment also comprises 1.7 to 3.5 weight parts of cinnamon. The Chinese medicinal liniment also comprises 1 to 3 weight percent of frankincense. The traditional Chinese medicine liniment also comprises mint, wherein the mint accounts for 2.2-3% of the weight. Compared with the existing traditional Chinese medicine liniment, the traditional Chinese medicine liniment for treating neuralgia provided by the invention is more comprehensive in formula, is used for bacteriostasis, cleaning and nursing of skin and treating neuralgia, and has better bacteriostasis and pain relieving effects.
Usual care for AHF. It is recommended to administer an intravenous loop diuretic dose at least BID (or through continuous infusion), with the aim of achieving a urine output 3-5 L per day until the patient is considered in an optimal volume status as is recommended by current guidelines. Urine electrolyte assessment in the control arm is not allowed as it is a key component of the studied intervention.
The present invention relates to an ointment for treating various skin diseases and a preparation method thereof. The ointment for treating various skin diseases is prepared from that traditional Chinese medicines of borneol, massicot, realgar, yellow lead, alum, calomelas, sublimated sulfur, etc. and western medicines of chloromycetin, rifampin, mycostatin, etc. are taken as raw materials to prepare medicinal powder, and vaseline or lard is used as a solvent; the ointment is prepared by a modern scientific preparation method. The ointment is spread on the surface of skin for treating various skin diseases, such as dermatitis, tinea, sore, beriberi, eczema, bedsore, impetigo, scabies, etc., and the total effective rate can reach 96%. The ointment has the advantages of easy preparation, low cost, high curative effect, short course of treatment, quick effect, convenient use, treatment of both symptoms and radical causes of skin diseases and wide application range. The ointment is an ideal mixture ointment for both Chinese medicines and western medicines.
Post-prandial study feeding 2 g of carotenoid powder formula (845 µg sapotexanthin, 1.21-1.51 mg cryptocapsin), 37.5 g of sugar, 75 µg of citric acid, 6 g of soybean oil emulsified into 300 g of water using 3 g of soy lecithin as well as ca. 100 g of crushed ice, yielding a shake volume of 450 mL.
As part of retinal detachment surgery, the eye is typically filled with a gas bubble or silicone oil bubble. This bubble acts like a balloon inside the eye and helps to keep the retina pushed back against the eye wall so it can heal in its proper place. Gas bubbles spontaneously dissolve over a few weeks whereas silicone oil remains in the eye until removed with another surgery. When retinal detachments are associated with significant scar tissue on the retinal surface, silicone oil is often used since it can remain filling the eyeball for as long as necessary to help the retina to heal properly in place. Currently, two different types of silicone oil (1000 centistoke and 5000 centistoke) are commercially available and have been approved for use in the eye by the Food and Drug Administration. The goal of the study is to compare the outcomes using these two different types of silicone oil.

The retinal detachment will be repaired in a standard fashion. There will be no difference between the way retinal detachments are repaired in this study compared to those not in this study. Patients will be randomly assigned (like a flip of a coin) to receive one of the types of silicone oil. Both types of oil have very similar characteristics. The primary difference is that one type is thicker (more viscous) than the other, analogous to honey in comparison with maple syrup.
These patients will then receive bilateral cervical nodal irradiation with the primary post operative site excluded (30 fractions). They will be monitored for both physician reported toxicities.
NEW MATERIAL:A compound shown by formula I (n is 8-16 integer) and a salt thereof. EXAMPLE:N-Lauroyl-N-(3-hydroxypropyl)glycine. USE:A surface active agent preferably usable for heir and skin detergent for little children, kitchen detergent for housewives having the hands to be readily chapped, daily shampoo, shampoo for beauty culture having low irritation, etc., because of improved hard water resistance, low irritation and improved surface active performance. PREPARATION:A compound shown by formula II is reacted with a compound shown by formula III in the presence of a base to give a compound shown by formula I. The compound keeps effects as surface active agent when it is used not only for city water but also underground water, hot spring, seawater, etc., and use of the compound as an additive for other surface active agents provides hard water with foam increasing effects. Further it is usable as a detergent for metallic surface, antistatic agent, fiber treatment, penetrating agent, emulsifying agent for emulsion polymerization, etc., similarly as an ordinary surface active agent.