anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A nutraceutical product for the symptomatic management of cough composed of Lagundi (Vitex negundo) and Luya or Ginger (Zingiber officinale). Lagundi is credited with many medicinal properties, as an analgesic, anti-inflammatory, anti-oxidant, bronchial relaxant, and hepatoprotective. Luya contains active ingredients that have been shown to have analgesic, anti-inflammatory, antiemetic, muscle relaxant, and anti-oxidant properties. The specific pharmacokinetic interactions of the compounds found in both plants are not known. Active compounds in Vitex negundo and Zingiber officinale have known anti-inflammatory properties through prostaglandin inhibition, anti-histamine, anti-infective actions. These compounds act to augment innervations of cough receptors, as well as relieve bronchospasm and edema caused by endogenous neuropeptides, histamine, and eicosanoids. This dual component herbal is indicated for relief of cough due to common cold and flu, bronchospasm in bronchial asthma, chronic bronchitis and other bronchopulmonary disorders.
Participants will orally ingest a capsule identical to that containing the study medication, however this capsule will contain a placebo. They will ingest this capsule daily (Monday-Friday) for the first 2 weeks of rTMS treatment (10 sessions), followed by 2 weeks of rTMS without adjunctive medication.
The invention provides an artificial tooth implant suitable for a teaching hospital. The artificial tooth implant comprises a tapered spiral-root-shaped implant, an implant neck, a neck thread and a root tip thread. The artificial tooth implant is characterized in that the upper part of the implant neck is provided with a tapered connection hole with a circular section and without a base station and a thread, the two thirds part in the bottom of the connection hole is a hex hole, and the one third part outside the connection hole is of a conical hole structure. According to the tapered spiral-root-shaped implant, the neck thread is triangular, and the root tip thread is trapezoid; and the heights of the threads gradually decrease from the triangular neck thread to the trapezoid root tip thread, and the heights of the treads gradually increase circle after circle from the trapezoid root tip thread to the triangular neck thread. The artificial tooth implant is low in cost, simple and convenient in technology, easy to learn, high in success rate and easy for realization of mass production. The implantation of the artificial tooth implant does not need imported equipment and can be implemented by few simple manual tools, therefore, most of the old can afford to implant teeth, and graduates from a dental department of a medical university can have enough clinical practice.
Gemcitabine 1000 mg/m\^2 i.v. on days D1, D8, D15 of a 28-day cycle.
BACKGROUND: Functional mitral regurgitation (FMR) and its severity are associated with adverse outcomes in heart failure patients. This study aims to analyze the predictors of FMR improvement after successful left bundle branch area pacing (LBBAP) in patients with LVEF < 50% and complete left bundle branch block (CLBBB).
METHODS: Consecutive patients with LVEF < 50% and CLBBB who underwent successful LBBAP from July 2018 to July 2023 were retrospectively identified. Significant MR was defined as regurgitation of moderate severity or greater. Patients with significant FMR were included in the analysis. FMR improvement (FMRI) was defined as a reduction of at least one grade in regurgitation severity compared to baseline at 3 months or longer follow-up.
RESULTS: Among the 81 identified patients, 42 patients with significant FMR preoperatively were included. After LBBAP, QRS duration significantly shortened from 170.6 ± 18.8 ms to 114.5 ± 20.2 ms (p < .001). Significant FMR improves in approximately 76.2%, and the patients were divided into an FMRI group (n = 32) and a non-FMRI group (n = 10). Univariate analysis showed that absence of persistent atrial fibrillation, typical CLBBB, and left atrium diameter at baseline were associated with improvement of FMR after LBBAP. Of these variables, only absence of persistent atrial fibrillation remains an independent predictor in the multivariate model (OR 12.436, p = .009).
CONCLUSION: LBBAP is able to improve FMR in heart failure patients who had CLBBB with LVEF < 50%. Meanwhile, the absence of persistent atrial fibrillation is an independent predictor of FMR improvement.
PROBLEM TO BE SOLVED: To provide a device and method for delivery of an active pharmaceutical ingredient (API) to an anal sphincter.SOLUTION: A rectally insertable device 20 comprises a shell 22 for containing an active pharmaceutical ingredient (API) 24. The upper end and sides of the shell are preferably smoothly continuous, and are formed from a material which is impermeable to the API, such that the API is unable to pass through the shell into the rectum. The shell may be constructed from at least one layer of any non-irritating material which is impermeable to the API and which is sufficiently strong not to tear during insertion into the rectum. The layer should be thin enough so that the shell is sufficiently flexible to avoid unnecessary patient discomfort. The shell should also be compatible with a lubricant used in conjunction with the device. Examples of materials suitable for use in constructing the shell include rubber, latex, silicon, polyvinylchloride, and polyurethane. Preferably, the shell is provided with a rounded tip 27 to minimize discomfort to the subject during insertion.
Quercetin (QUE) has been found to inhibit the progression of sepsis-related diseases, including sepsis-induced cardiomyopathy (SIC). More information about the role and mechanism of QUE in SIC progression deserves further exploration. Human cardiomyocytes (AC16) were induced with LPS to mimic SIC cell models. Cell proliferation and apoptosis were determined using CCK8 assay, EdU assay, and flow cytometry. Cell inflammation and ferroptosis were evaluated by detecting IL-1β, TNF-α, Fe2+, ROS, GSH, and GPX4 levels. 5-lipoxygenase (ALOX5) expression was examined by quantitative real-time PCR and western blot. LPS treatment reduced AC16 cell proliferation, while enhanced apoptosis, inflammation, and ferroptosis. QUE repressed LPS-induced AC16 cell apoptosis, inflammation, and ferroptosis. ALOX5 was upregulated in SIC patients, and its expression was reduced by QUE. ALOX5 knockdown restrained LPS-induced apoptosis, inflammation, and ferroptosis in AC16 cells. The inhibitory effect of QUE on LPS-induced myocardial injury could be reversed by ALOX5 overexpression. QUE promoted the activity of PI3K/AKT pathway by reducing ALOX5 expression. QUE could alleviate LPS-induced myocardial injury by regulating ALOX5/PI3K/AKT pathway, suggesting that QUE might be used for treating SIC.
Child Centered Therapy provides 12 sessions (45 minutes child, 45 minutes parent) of supportive interventions. This includes client-directed activities focused on the needs and interests of the child or parent, respectively.
FIELD: chemistry of polysaccharides.SUBSTANCE: invention relates to the chemistry of polysaccharides. Disclosed is a bioactive composition based on a cross-linked hyaluronic acid (HA) salt containing resveratrol. The average molecular weight of hyaluronic acid is 1800 kDa. Resveratrol in the composition is chemically bound with hyaluronic acid at the same time being a bifunctional cross-linking agent for it. The composition is a dry powdery substance with the following ratio of components, wt%: resveratrol - 0.5-1.5; hyaluronic acid - 98.5-99.5. Also disclosed is a method for producing a bioactive composition based on a cross-linked hyaluronic acid salt. The method involves mixing powdered hyaluronic acid with an average molecular weight of 1800 kDa with resveratrol powder for homogenizing the mixture in a mill at 15-40°C for 10-15 minutes and mechanochemical processing by feeding the resulting homogeneous mixture of powders into a mechanochemical reactor such as a twin-screw extruder with sequential automatic moving to the feeding zone and the second and third zones of mechanochemical treatment with the ratio of the lengths of the zones, respectively,%: 20:40:40. Mechanochemical treatment is carried out with the pressure within 500-600 MPa and shear deformation of cam mechanisms with a shear angle of 180° in total for 2-4 minutes in a nitrogen flow at a temperature of 5-10°C in the feed zone, at a temperature of 90-100°С in the second mechanochemical zone and at a temperature of 5-15°С in the third mechanochemical zone.EFFECT: invention is aimed at obtaining a composition in which the macromolecular chains of HA are cross-linked with resveratrol as well as at the development of an environmentally friendly method for obtaining the composition, which makes it possible to obtain previously unknown cross-linked HA salts chemically modified with resveratrol in a one-stage technological mode in the absence of a liquid medium without high energy labor and water consumption while receiving target products with a high yield.2 cl, 3 dwg, 4 ex
Subjects are assigned to a controlled arm whereas no intervention were done. They should underwent the same cognitive evaluations than active comparator at week 1 and 12.
There was no evidence of carcinogenicity when mice and rats received ivabradine up to 104 weeks by dietary administration. High doses in these studies were associated with mean ivabradine exposures of at least 37 times higher than the human exposure (AUC0-24hr) at the MRHD.

Ivabradine tested negative in the following assays: bacterial reverse mutation (Ames) assay, in vivo bone marrow micronucleus assay in both mouse and rat, in vivo chromosomal aberration assay in rats, and in vivo unscheduled DNA synthesis assay in rats. Results of the in vitro chromosomal aberration assay were equivocal at concentrations approximately 1,500 times the human Cmax at the MRHD. Ivabradine tested positive in the mouse lymphoma assays and in vitro unscheduled DNA synthesis assay in rat hepatocytes at concentrations greater than 1,500 times the human Cmax at the MRHD.

Reproduction toxicity studies in animals demonstrated that ivabradine did not affect fertility in male or female rats at exposures 46 to 133 times the human exposure (AUC0-24hr) at the MRHD.
Extra lung mucus secretions, injured mucosa, contaminants, and aspirated substances should be handled in their early stages. In the case of fibrinous material transudates, compromised mucociliary secretions and mucosal slough must be cleared. There are different methods to assist the clearance of secretions as bronchoscopy, ventilator, mucolytics, suction, and chest physiotherapy.

In Pilates method (PM), several muscles are activated, including the muscles involved in breathing, especially to improve the expiratory function, which remains contracted during the inspiratory and expiratory phase. Breathing control is fundamental during the execution of PM exercises, where the practitioner learns how to breathe properly as an essential part of each exercise through forceful exhaling followed by complete inhaling. Thus, adequate breathing aids in controlling movements, and therefore, the method can be regarded as an indirect strategy for respiratory muscle training. It is known that poor control of breathing can result in compensation and lung volumes and respiratory muscle performance, with several factors involved.
PURPOSE:To efficiently produce silver water at a low cost by forming a carrier having a large surface area with an org. or inorg. material, activating the carrier by chemical treatment, coating the activated carrier with fine silver particles and bringing the coated carrier into contact with water. CONSTITUTION:A carrier having the max. surface area is formed with an org. or inorg. material such as ceramic balls. The surface of the carrier is activated by chemical treatment with hydrofluoric acid, etc., and the activity is maintained by chemical plating such as electroless plating. The surface of the carrier is then coated with fine silver particles of several to several ten mum particle size and the coated carrier 1 is put in a vessel 3 and brought into contact with ordinary or structural water. Silver water having a lasting effect is produced in large quantities with high productivity.
2 Study Aims and Objectives To investigate the effect of metformin treatment on metabolic parameters in patients with long-term high dose GCs.

3 Study Design 3.1 General Design We will recruit patients (18-75y) requiring glucocorticoid treatment for various inflammatory conditions (e.g. rheumatoid arthritis, giant cell arteritis/polymyalgia rheumatic, asthma, sarcoidosis) into a pilot, randomised, double-blind, placebo-controlled trial. These patients will be treated with metformin to prevent or reverse their metabolic complications. Prevention algorithm: Patients who are about to start GC treatment predictably for ≥12w at a ≥10mg/d prednisolone (or equivalent) dose who consent to participate in this study will be randomly assigned to receive either placebo (20 patients/group, see power calculations) or metformin at the maximum tolerated dose with a minimum of 850 mg bd for 12w. Treatment algorithm: Consenting patients already on long-term GC treatment (≥4w, ≥20mg/d prednisolone or equivalent) who are expected to continue for at least 12w at ≥10mg/d prednisolone will be randomly assigned to receive either placebo or metformin for 12w. In both algorithms, metformin treatment will be started gradually (as standard practice) to avoid gastrointestinal side effects and the full dose will be reached by day 10. Patients will have a full clinical assessment before the start of the metformin treatment and at the end of the 12w treatment period. Anthropometric and biochemical parameters and questionnaires will be repeated at 4 and 8 weeks.
PURPOSE:To continuously exhibit a necessary effect by encapsulating a core substance consisting of a hydrophobic liq. substance having volatility with a wall film consisting of the condensation product of a specified amino compd. and formaldehyde to slowly release the core substance. CONSTITUTION:The hydrophobic substance having volatility is added into an aq. acidic medium contg. a small amt. of a styrene-maleic anhydride copolymer, etc., kept at 3-6 pH, agitated at high speed, and emulsified or dispersed. Meanwhile, an alkali is added to formaline to control the pH to 8-10, a requisite amt. of >=1 kind of amino compd. among guanidine, melamine, urea, and the derivative thereof is added, and the mixture is heated to obtain an aq. soln. of a methylolated amino compd. The aq. soln. is added to the liq. dispersion or emulsion of the core substance, the materials are allowed to react with each other, and a slowly-releasable wall film consisting of the condensation product of the amino compd. and formaldehyde is formed around the core substance.
PROBLEM TO BE SOLVED: To confirm effects such as antimicrobial activity, suppression of uresase activity, intragastric fixability and interleukin-8 generation, or the like, against Helicobacter pylori which is a pathogen of gastritis, gastric ulcer and duodenal ulcer and then to identify and obtain an active ingredient against Helicobacter pylori from Perilla frutescens var. acuta KUDO which is a food material. SOLUTION: This extract comprises one or more kinds of hot-water extracts produced by adding water in an amount of 5-20 times weight based on the Perilla frutescens var. actua KUDO, carrying out hot-water extraction thereof at 80-120 deg.C for 6-15 h and carrying out vacuum concentration of the filtrate under 40-70 cmHg and a solvent extract produced by adding 50-70% ethanol in an amount of 5-20 times weight based on the amount of the crude drug material, then extracting at 50-90 deg.C for 4-8 h and carrying out vacuum concentration of the filtrate under 40-70 cmHg, and has the effects such as the antimicrobial activity and the suppressions of urease activity of Helicobacter, of gastric epithelial cell fixability and suppression of interleukin-8 purification against the Helicobacter pylori.  Besides, a berberine becomes a main active ingredient in the extract of the Perilla frutescens var. acuta KUDO by dividing a water-soluble layer obtained therefrom using an organic solvent such as chloroform and an XAD-7 column chromatography and a silica column chromatography and separating the main active ingredient by using a preparative thin layer chromatography(TLC).
This is a prospective observational multicenter study including patients affected by patients with macroscopic recurrence within prostate bed after RP detected with Choline or PSMA CT-PET and confirmed with pelvic MRI (except for cases in which MRI is contraindicated). Patients will be treated with SSRT on macroscopic prostate bed recurrence for a total dose of from 35 in 5 fractions. Planned size of the overall study population is 90 patients. The study will include a screening phase and a treatment phase. The screening phase allows for assessment of subject eligibility, demographics, PSA, comorbidities and current drug therapies up to 45 days prior to randomization.

The treatment phase consists of SSRT administered on prostate bed macroscopic recurrence. Different techniques will be allowed provided that treatment respects doses and fractionation indicated per-protocol (35 Gy in 5 fractions) and that dose constraints to organs at risk (OAR) reported in this document are observed. The total planned duration of the study is 40 months, consisting in 16 months enrollment period, during which patients will perform the screening and and later phase of 24 months in which patients will continue to be submitted to periodic checks every 3 months.
Use with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function. 

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. 

Thiazides may add to or potentiate the action of other antihypertensive drugs. Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma. 

The possibility of exacerbation or activation of systemic lupus erythematosus has been reported. 

Lithium generally should not be given with diuretics (see PRECAUTIONS, Drug Interactions).
IMPORTANCE: Research is beginning to elucidate the sophisticated mechanisms underlying the microbiota-gut-brain-immune interface, moving from primarily animal models to human studies. Findings support the dynamic relationships between the gut microbiota as an ecosystem (microbiome) within an ecosystem (host) and its intersection with the host immune and nervous systems. Adding this to the effects on epigenetic regulation of gene expression further complicates and strengthens the response. At the heart is inflammation, which manifests in a variety of pathologies including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis (MS).
OBSERVATIONS: Generally, the research to date is limited and has focused on bacteria, likely due to the simplicity and cost-effectiveness of 16s rRNA sequencing, despite its lower resolution and inability to determine functional ability/alterations. However, this omits all other microbiota including fungi, viruses, and phages, which are emerging as key members of the human microbiome. Much of the research has been done in pre-clinical models and/or in small human studies in more developed parts of the world. The relationships observed are promising but cannot be considered reliable or generalizable at this time. Specifically, causal relationships cannot be determined currently. More research has been done in Alzheimer's disease, followed by Parkinson's disease, and then little in MS. The data for MS is encouraging despite this.
CONCLUSIONS AND RELEVANCE: While the research is still nascent, the microbiota-gut-brain-immune interface may be a missing link, which has hampered our progress on understanding, let alone preventing, managing, or putting into remission neurodegenerative diseases. Relationships must first be established in humans, as animal models have been shown to poorly translate to complex human physiology and environments, especially when investigating the human gut microbiome and its relationships where animal models are often overly simplistic. Only then can robust research be conducted in humans and using mechanistic model systems.
FIELD: medicine. SUBSTANCE: method involves taking lymph sample, holding it at 4 C during 1 day or centrifuging during 30 min at 1500 rpm. Formed lymph elements settle to reservoir bottom and plasma cleared from the formed elements, remains at the top. The plasma is sucked off. Antitumoral chemotherapeutic preparations are combined with the formed lymph elements in high doses, held in thermostat at 37 C during 1.5 h and reinfused intravenously in drops to the patient. EFFECT: enhanced effectiveness in treating nonoperable cancer cases transforming them into operable state; reduced toxic action of antitumoral preparations. 4 cl, 1 dwg, 1 tbl
Patients suffering from post-acute sequelae of COVID-19 (PASC) have a higher prevalence of anxiety and depression than the general population. The long-term trajectory of these sequelae is still unfolding. To assess the burden of anxiety and depression among patients presenting to the University of Iowa Hospitals and Clinics (UIHC) post-COVID-19 clinic, we analyzed how patient factors influenced Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) scores. In this retrospective cohort study, the GAD-7 and PHQ-9 questionnaire scores of patients presenting to the UIHC post-COVID clinic between March 2021-February 2022 (N = 455) were compared to the scores of a sample of patients presenting to the general internal medicine (GIM) clinic during the same period (N = 94). Our analysis showed that patients with an absent history of depression on their electronic medical record (EMR) problem list scored significantly higher on the GAD-7 (mean difference -1.62, 95% CI -3.12 to -0.12, p = 0.034) and PHQ-9 (mean difference -4.45, 95% CI -5.53 to -3.37, p < 0.001) questionnaires compared to their similar counterparts in the GIM clinic. On the other hand, patients with an absent history of anxiety on their EMR problem list scored significantly higher on the GAD-7 (mean difference -2.90, 95% CI -4.0 to -1.80, p < 0.001) but not on the PHQ-9 questionnaire (p = 0.196). Overall, patients with PASC may have experienced a heavier burden of newly manifest anxiety and depression symptoms compared to patients seen in the GIM clinic. This suggests that the mental health impacts of PASC may be more pronounced in patients with no prior history of anxiety or depression.
FIELD: proteins, hormones. SUBSTANCE: invention relates to water-soluble aggregate of insulin derivatives where residues B24-B30 of B-chain of insulin derivative are presented by sequence: Phe-X-X-X-X-X-X wherein each X represents independently any amino acid or deletion; at least one X is N ε -substituted lysine residue wherein substituent is 5-α-lithocholic acid or 5-β-lithocholic acid bound via α-glutamyl, γ-glutamyl or β- or α-aspartyl as linker. Aggregate has size determined by gel-filtration method that is greater than that of aldolase and aggregate comprises at least 2 zinc ions per 6 molecules of insulin derivative. Invention provides prolonging effect of insulin derivatives. EFFECT: valuable medicinal properties of aggregate. 7 cl, 4 dwg, 2 tbl