anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A composition for activating mitochondria containing a ginseng fruit extract is provided to effectively treat or prevent diseases related to the functional reduction of mitochondria. CONSTITUTION: A composition for activating mitochondria contains a ginseng fruit extract as an effective substance. The composition enhances the muscles. The composition prevents or treats degenerative diseases, brain disorders, neural diseases, heart diseases, liver diseases, kidney diseases, pancreatic diseases, or muscle diseases. The composition activates mitochondria. 10-90 weight% of the effective substance is included in the composition based on the total weight of the composition. [Reference numerals] (AA) Control group; (BB) Positive control group; (CC) Example 1; (DD) Example 2; (EE) Example 3; (FF) Ginsenoside Rg; (GG) Ginsenoside Rb; (HH) Ginsenoside Re
The SECUADO placebo-controlled trial for the treatment of schizophrenia did not include sufficient numbers of patients aged 65 and over to determine whether or not they respond differently than younger patients. Of the approximately 614 patients in placebo-controlled study of SECUADO, 1.6% (10) were 65 years of age or over.

Multiple factors that might increase the pharmacodynamic response to SECUADO, causing poorer tolerance or orthostasis, could be present in elderly patients, and these patients should be monitored carefully. Based on a pharmacokinetic study in elderly patients with sublingual asenapine, dosage adjustments are not recommended based on age alone [see Clinical Pharmacology (12.3)].

Elderly patients with dementia-related psychosis treated with SECUADO are at an increased risk of death compared to placebo. SECUADO is not approved for the treatment of patients with dementia-related psychosis [see Warning and Precautions (5.1, 5.2)].
25% Dextrose Injection, USP is a sterile, nonpyrogenic, hypertonic solution of dextrose in water for injection administered by intravenous injection to restore blood glucose levels in hypoglycemia and as a source of carbohydrate calories. Each milliliter (mL) of fluid contains dextrose, hydrous, 250 mg which delivers 3.4 kcal/gram (0.85 kcal/mL). The solution has an osmolarity of 1.39 mOsmol/mL (calc.). pH is 4.5 (3.2 to 6.5). May contain hydrochloric acid and sodium hydroxide for pH adjustment. The solution contains no bacteriostat, antimicrobial agent or added buffer (except for pH adjustment) and is intended only for use as a single-dose injection. When smaller doses are required the unused portion should be discarded with the entire unit.  
25% Dextrose Injection, USP is a dextrose (glucose) and nutrient (carbohydrate) replenisher. Dextrose, USP is chemically designated D-glucose monohydrate, (C6H12O6• H2O), a hexose sugar freely soluble in water.   
It has the following structural formula:

The syringe is molded from a specially formulated polypropylene. Water permeates from inside the container at an extremely slow rate which will have an insignificant effect on solution concentration over the expected shelf life. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the syringe material.
BACKGROUND: This study aimed to compare the risk of revision for aseptic loosening in obese (body mass index >30 kg/m2) patients with stemmed (ST) versus non-stemmed (NST) tibial implants in primary total knee arthroplasty (TKA).
METHODS: A systematic review and meta-analysis were conducted following PRISMA and MOOSE guidelines. Studies reporting a direct comparison between ST and NST tibial implants in obese patients were included. The primary outcome of interest was revision for aseptic loosening. Outcomes were analysed using meta-analysis of relative risk. Risk of bias assessment was performed using the Newcastle-Ottawa Scale for observational studies and the RoB-2 Cochrane tool for randomised studies.
RESULTS: Seven studies met the selection criteria, consisting of four cohort studies and three randomised controlled trials. Mean follow up time for the eligible cohort was 62.6 months. Meta-analysis demonstrated a statistically significant reduction in the risk of aseptic revision in the ST group compared with the NST group (risk ratio 0.25, 95% confidence interval 0.07 to 0.92). After removal of all zero-event studies, the results remained in favour of the ST group (risk ratio 0.15, 95% confidence interval 0.03 to 0.64).
CONCLUSIONS: This study found that obese patients undergoing TKA with stemmed tibial implants may have a lower risk of aseptic revision compared with those with non-stemmed tibial implants. However, due to the lack of high-quality literature available, our study is unable to draw a definitive conclusion on this matter. We suggest that this topic should be re-evaluated using higher-quality study methods, particularly national joint registries studies and randomised controlled trials.
The invention discloses a pharmaceutical composition containing albendazole for resisting microsporidia for silkworms. The pharmaceutical composition is a medicine compound powder prepared from albendazole, enrofloxacin, a filler and an appropriate compound cosolvent. The pharmaceutical composition disclosed by the invention can be applied to prevention and treatment of a pebrine disease and bacteriosis, and comprises two application modes: directly spraying the medicine compound powder on mulberry leaves to feed silkworms, or blending the medicine compound powder with water, preparing a solution, soaking the mulberry leaves and airing to feed the silkworms. The administration time is continuous 12-15 days until mounting and cocooning of silkworm from the fourth larva of silkworm; and the composition is fed once a day except for a moulting stage. The application method disclosed by the invention is convenient, simple and relatively practical. A result proves that a pebrine disease of the silkworms can be effectively prevented and treated.
All treatment stages were performed by the same experienced pediatric dentist (E.O.) to avoid behavioral problems. When necessary, topical anesthesia with 2% Xylocaine® DENTAL was administered, followed by local anesthesia with epinephrine 1: 100.000 (lidocaine HCl and Epinephrine Injection, DENTSPLY Pharmaceutical, USA). Access to proximal surfaces was provided with high-speed diamond bur (FD.D.801, Frank Dental, Germany) under an air-water coolant. The proximal cavity was opened at the occlusal level. Soft carious dentine was removed with a round low-speed steel bur (SS.1A, Frank Dental, Germany).

Restorations were placed under isolation with cotton rolls and a saliva ejector. The Ca(OH)2 cavity liner material (Hydrocal LC, Medicept Dental, India) was used as base material if the distance from the pulp was not safe. A metal matrix band (Matrix band, Hahnenkratt, Königsbach-Stein, Germany) was applied to the tooth with a universal matrix system (Tofflemire, Hahnenkratt, Königsbach-Stein, Germany) and wooden wedges (TDV, No 1). ClearfilTM SE Bond (Kuraray Medical Inc, Okayama, Japan) was applied to the cavity according to the manufacturer's instructions. For the polymerization, an LED curing light (Eliapar Freelight, 3M ESPE Dental Products, America) was used with a light power density of 600 mW/cm2. According to the manufacturer's instructions, A2 composite resin (Kerr Herculite Classic) and two different compomer materials (Dyract/XP and R\&D Series NOVA) were applied to the teeth with the incremental technique, and each increment was light-polymerized for 20 sec with an LED curing light.
This study will test the effectiveness of aerobic exercise on improving sleep in patients with systemic lupus erythematosus. The subjects will do treadmill 2 times per week, from 15-20 min. with low to moderate(55-65% maxCF) intensity exercise, so 30 min. until 4ª week. From the 5ª to 8ª week they will be able to make greater efforts to 35-40 min. totalizing 16 weeks. The control group will not do exercise and will receive education class about disease, health, sleep, 1 time per month.
Participants randomized to Condition 4 will view only stratified transplant survival outcome information when making a choice between the two hospitals. The "survival following transplant" metric is displayed as a pair of quintile scores corresponding to two distinct groups of transplant patients at the center: those who received optimal donor organs and those who received adequate donor organs.
PURPOSE:To obtain a cleansing agent composition for hair, etc., excellent in stability with time by dispersing a mixture of silica particles or a solvent insoluble silicone resin, a water soluble silicone derivative and dimethylpolysiloxane in an aqueous surfactant solution. CONSTITUTION:This cleansing agent composition excellent in stability with time and foamability, without sticking and excellent in conditioning effect is obtained by dispersing a mixture of (A) silica particles or a solvent insoluble silicone resin, (B) a water soluble silicone derivative and (C) dimethyl polysiloxane in an aqueous surfactant solution. The average size of A is preferably 0.01-500mum. The water soluble silicone derivative B is preferably a compound expressed by the formula I, II or III [R<1> is the formula IV (R<2> is a hydrocarbon, (c) is 0 or 1; (d) is 1-5: (e) is a number by which its degree of polymerization becomes >=40wt.%.), etc.].
PURPOSE: To obtain a dental implant which a ligature fixed to a bio-absorptive net material for only causing the lowest number of fixing holes on the bio- absorptive net material by composing a bio-absorptive half porous material, and providing an enclosed edge. CONSTITUTION: A net-shaped packing structure 10 made of a bio-absorptive material is made, for instance, by a laser-cutting without coming loose, and has a smooth edge. A ligature 12 made of the bio-absorptive material is fixed to a net-shaped inserting structure 10, the net-shaped inserting structure 10 can be firmly held in tooth. Fixing of the ligature 12 to the net-shaped inserting structure 10 is conducted by welding of laser or ultrasonic wave for example without producing any additive hole upon the net-shaped inserting structure. Otherwise the ligature 12 may be woven into the net-shaped inserting structure 10. By means of a presence of a fused edge and hole, transition of epithelial cell to a surface of tooth through the hole is not caused.
Maintaining gastrointestinal (GI) microbiome diversity has been shown to improve treatment related mortality in HSCT patients. Interventions to improve GI microbial diversity could be beneficial to this patient population. Diets rich in prebiotics have been shown to increase gut microbial diversity and improve symptoms in other gastrointestinal diseases. Prebiotics are non-digestible carbohydrates that promote growth of commensal organisms in the gut by providing nutrition. Some examples are brown rice, green apples, and tomatoes. Our theory is that consuming a diet rich in prebiotics pre- and during the first 100 days following HSCT will help to reduce acute graft versus host disease (aGVHD) overall, and specifically acute GI GVHD, and clostridium difficile (C.Diff). Participants will be encouraged to eat at least 2 servings of a prebiotic-rich food from time of admission for HSCT through 100 days following HSCT and will be clinically monitored, including for acute GVHD, acute GI GVHD and C.Diff. Stool samples will be collected from all participants about once every 4 weeks.
Iatrogenic arteriovenous fistula (AVF) is a complication accompanying venous and arterial puncture. Herein we report a case of ligation closure of an iatrogenic AVF in the brachial artery after percutaneous coronary intervention (PCI) for the patient with end-stage kidney disease (ESKD). A 68-year-old woman presented with a history of several coronary angiographies (CAG) and PCI through the right brachial artery. After PCI, the patient experienced a thrill in the right elbow. Two years later, the patient initiated hemodialysis (HD) using a temporary HD catheter for ESKD and congestive cardiac failure. Ultrasonography and computed tomographic angiography revealed an iatrogenic AVF between the right brachial artery and the medial brachial vein. Blood flow in the brachial artery was 760 mL/min. However, the iatrogenic AVF was unusable as vascular access for HD, and prior ligation closure of the iatrogenic AVF was performed, considering the risk of cardiac failure due to double AVFs after the creation of a new AVF for HD. Subsequently, a new radial-cephalic AVF was created in the left forearm. Therefore, clinicians should consider the possibility of iatrogenic AVF in patients with ESKD having a history of CAG or PCI.
A packaging cell line that complements recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary, diploid human cells that are transformed by adenovirus E1 sequences either operatively linked on one DNA molecule or located on two separate DNA molecules, the sequences being operatively linked to regulatory sequences enabling transcription and translation of encoded proteins. Also disclosed is a cell line derived from PER.C6 that expresses functional Ad35 E1B sequences. The Ad35-E1B sequences are driven by the E1B promoter or a heterologous promoter and terminated by a heterologous poly-adenylation signal. The cell lines are useful for producing recombinant adenoviruses designed for gene therapy and vaccination. The cell lines can also be used for producing human recombinant therapeutic proteins such as human growth factors and human antibodies. Also, the cell lines are useful for producing human viruses other than adenovirus such as influenza virus, herpes simplex virus, rotavirus, and measles virus.
A new cultivar of medicinal cannabis has been bred that renders large amounts of cannabidiolic acid (mg/gram ground flower weight)... greater than 10%. The cultivar moved from an outdoor to indoor environment produced similar levels of cannabidiolic (CBD) and similar cannabinoid profiles. Reproduced asexually, the same (greater than 10%) cannabidiolic acid amounts were rendered and this remains constant crop to crop.  THC levels do not change between 20 and 30% of that of the CBD-A  concentration.  High Pressure Liquid Chromatography (HPLC) determines Cannabinoid profiles where the amounts of the three most abundant cannabinoids (tetrahydrocannabinol, cannabinol and cannabidiol) and their acids are quantified. The cannabinoid profile relates directly to the physiological effects of the plant as a medicine. In addition, a genetic fingerprint of the strain has been generated using gel electrophoresis. Strains high in cannabidiolic acid are rare since commercial breeding has led to strains with large concentrations of tetrahydrocannabinol (THC) and very little cannabidiol making the strain in question rare. Hayley's Comet provides a unique cannabinoid profile containing large concentrations of CBD-A making it useful for medicaments for seizure disorder, pain and inflammation.
Participants will receive single oral dose (low) of JNJ-0440 or matching placebo under fed conditions. The dose will be escalated based on the preliminary safety data from the preceding cohort as per sponsor and investigator discretion.
In the Control group, either before or after PCI a loading dose of Clopidogrel will be administered and a manteinance daily dose of 75mg will be associated with oral ASA (100mg). PCI procedure will be performed as per current cinical practice, according clinical guidelines and at operator discretion.
Participants in this group will complete 3 sessions of social support effectiveness training. All will complete 1 follow-up call after the 3 sessions have been completed.
Three decades since its comprehensive description (Taylor et al., 1971), focal cortical dysplasia (FCD) remains an enigmatic condition. FCD may cause severe refractory epilepsy that can be directly life threatening. Preoperative neuroimaging usually includes high-resolution MR imaging, which can reveal only 60 to 80% of cortical abnormalities in patients with FCD. When antiepileptic drugs fail to bring complete seizure freedom in FCD patients, surgical resection of the FCD is inevitable. Many patients, especially those with normal MR imaging results, undergo additional diagnostic procedures. Scalp EEG is frequently used and was one of the more important modalities during early surgical series. Approximately one half to two thirds of patients with abnormal EEG findings have a regional ictal abnormality. In some cases, intracranial electrophysiological recordings, most commonly with grid arrays, are used. Chronic recording allows identification of eloquent cortex areas, in addition to defining the epileptogenic region. The "eloquent brain" refers to the parts of the brain that allows the interaction with and the process of surrounding environment, via the senses, motion, language, memory and the purposeful use of tools. Nevertheless, all these techniques are either invasive or have a spatiotemporal resolution too poor to identify precisely the epileptic lesion deep in the brain. Hence, large resection of lesion areas, such as lobectomies and even hemispherectomies, are performed with a high risk of side effects including aphasia, partial face paralysis and hemiplegia depending on the localization of the lesion.

Navigable three-dimensional (3D)-MRI (based on Neuronavigation system) is currently used at the Sainte Anne hospital for planning and guiding during resection but neurosurgeons often complains about poor resolution and non-real-time imaging. While the use of surgical navigation has been an important advance in brain surgery, its utility is limited by the phenomenon known as brain shift. Whenever the brain is exposed, cerebral spinal fluid (CSF) is lost. Additionally, after the start of resectioning, the position of the surgical field can shift by centimeters, compared to the pre-surgery position. Brain shift makes it potentially hazardous to rely on preoperative images to determine the location of residual tumors. The only way to deal with brain shift and maintain accurate neuronavigation is with intraoperative imaging to enhance resection of the pathologic tissue in FCD.

Previously, the investigators demonstrated the feasibility of their approach by monitoring the hemodynamic responses during drug-induced epileptic seizures in preclinical models using functional micro-Doppler Sonography (fmDS).

The investigators are now developing this new tool combining a navigable three-dimensional (3D)-ultrasound interface to correct in real-time the brain shift (B-mode) with the near-real-time identification with unprecedented resolution of the dysplasia foci based on the specific hemodynamic signature of abnormal neurons.
Patients rinse and gargle with supersaturated calcium phosphate rinse over 1 minute QID beginning on the first day (about day -7) of the conditioning regimen. Treatment continues until day 20 post-transplantation.
PURPOSE: This study tested the hypothesis that our predominately AA medical center population would demonstrate a decline in HCV-driven HCC diagnosis following the initiation of DAA treatment in 2014. Also evaluated was whether achieving an SVR prior to diagnosis of HCC improved outcomes in patients who had an HCV diagnosis after completion of treatment.
METHODS: All patients with HCC seen at the Detroit Medical Center from 2009 to 2021 were identified using ICD-10 codes, and medical records were evaluated. Outcomes were evaluated as either alive or death/hospice as of December of 2022.
RESULTS: There were 461 patients with HCC of whom 433 (94%) had racial information in the database (AA = 351; non-AA = 82). HCC incidence regardless of race peaked in 2017, with a subsequent decline through 2021. HCV as a risk factor was higher in AA as compared to non-AA (85% vs. 53% p = 0.0001). Outcome (alive vs. death/hospice) was better for SVR patients compared to untreated patients (54% vs. 19%; p = 0.0009). HCC patients who achieved SVR also had better liver function at diagnosis as defined by Child-Pugh score (74% vs. 49% Class A p = 0.04) at the time of diagnosis.
CONCLUSIONS: Racial disparity in HCC etiology was confirmed with AA more likely to have HCV than non-AA. The reduction in HCC patients with HCV confirms the impact of DAA treatment and prior successful treatment of HCV yields better outcomes. Increasing HCV treatment rates especially in AA patients will have a major impact on HCC development and treatment outcomes.
WHAT IS KNOWN: • African Americans are more likely to have HCV infection as compared to non-AA. • Hepatocellular carcinoma is increasing in incidence in the US. • The role of HCV in the development of HCC remains to be further investigated.
WHAT IS NEW: • HCC diagnosis in a single urban medical center study increased from 2009 as a result of HCV as a risk factor. • HCC declined post 2018 due primarily to a reduction in HCV infection as the risk factor. • African Americans were more likely to have HCV as the risk factor as compared to non-AA patients who were more likely to have no known risk factor on record (i.e., cryptogenic).
PURPOSE:To use the titled antibiotic as a drug by its anbacterial action, by cultivating a bacterium belonging to the genus Streptomyces, and collecting a novel antibiotic from the culture mixture. CONSTITUTION:Streptomyces sp. S43405 (FERM P-7956) is cultivated in a nutrient medium by a culture method of common ray fungus under an aerobic condition by submerged spinner culture, etc. The culture mixture is separated into a mold and filtrate, the mold is extracted with a solvent, the extracted solution is concentrated to give an aqueous solution, which is incorporated with the filtrate, and the prepared mixture is extracted with a solvent, or treated with an ion exchange resin, etc. to separate and to purify novel antibiotic SS43405D. Antibiotic SS43405 has a formula of C23H18O7, 170 deg.C melting point, yellow crystal, is acidic, soluble in chloroform, alkali water, etc., slightly soluble in h- hexane, and water (formula).