Cerebral Small Vessel Disease (CSVD) causes 20-25% of strokes and is the most common cause of Vascular Cognitive Impairment (VCI). Patients with CSVD accumulate frequent, small brain infarcts, leading to accelerated functional and cognitive decline, but at present, there are no approved disease-modifying treatments. The prehospital setting of ischemic stroke care is another challenge. Many patients incur prehospital delays in their arrival to stroke centres, and in countries like Canada, patients often require an hour or more to be transported to hospital even under the best of circumstances due to geographic realities. Unfortunately, there are also no approved pre-hospital treatments for ischemic stroke, besides thrombolysis in a mobile stroke units (MSUs), meaning these patients end up losing too much brain tissue prior to hospital arrival. Remote Ischemic Conditioning (RIC) is a promising strategy to prevent infarct accumulation in CSVD, and also to mitigate infarct growth in ischemic stroke, offering the potential to tackle the treatment frontiers of CSVD and pre-hospital ischemic stroke in parallel. RIC induces brief periods of ischemia-reperfusion in a limb to protect a remote organ (e.g. brain) from injury through humoral and neuronal-mediated responses promoting cell survival/repair and inhibiting apoptosis/inflammation. In a bilateral carotid occlusion mouse model of VCI, daily RIC showed increased angiogenesis, cerebral blood flow, and preserved white-matter myelination at 4 months A few very small studies (17-36 participants) of RIC have been conducted in CSVD, suggesting that it may be associated with lower white matter hyperintensity volume and differences in visuospatial or executive function. The device we will be testing addresses the challenges with current RIC therapy options that previously limit our ability to conduct large-scale, high-quality trials.

For patients in the CSVD group, each RIC session will consist of 4 cycles, once daily of unilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes. The procedure will be performed using our device with single-arm cuffs that inflate to a pressure of up to 200 mmHg during the ischemic period. This will first be demonstrated by a clinic-based nurse and will subsequently be performed by the patient at home, once daily, for up to 60 days. The device records and documents each RIC cycle. The RIC process can be stopped at any time by the subject if the subject experiences any major discomfort. Half the patients will initially be receiving a control or sham treatment with the same device programmed remotely to inflate to only 30mmHg for the first 30 days before being switched over to the typical RIC treatment protocol.

For the patients in the MSU group, a cuff will inflate around one or both upper arms (both arms preferred if tolerated by the patient), up to 200mmHg to interrupt perfusion to the limb for approximately 5 minutes, after which it will deflate for around 5 minutes to restore normal blood flow. This cycle will repeat for a maximum of 6 cycles until the patient is transferred to the stroke hospital.

The paramedics and physicians in the usability testing group will be encouraged to try the device themselves for at least one complete RIC treatment session of 4 cycles, and also one sham treatment cycle. A subset of the paramedics and/or physicians will also test the device as part of a mock acute stroke code scenario in either an emergency room-type setting or on the MSU to help the investigators understand how the device might fit into the acute stroke workflow.