anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The overarching goal of this research project is to conduct a randomized efficacy trial of a preventive intervention-the Kids in Transition to School (KITS) program-to enhance socioemotional and academic school readiness among preschool-aged foster children. Foster children are at great risk for poor social and academic school outcomes. Because of their experiences of early adversity, these children may have particular vulnerabilities that decrease the likelihood of a successful transition to school. Extensive prior research has shown that chronic early adversity is associated with alterations in the functioning of key neural systems (specifically, prefrontal cortex function and hypothalamic-pituitary-adrenal axis activity) related to self-regulation and stress reactivity. Alterations in these systems may interfere with children's abilities to relate to peers, to maintain focused attention, to follow directions, and to learn academic skills. Additionally, because these children are likely to have experienced multiple living transitions, they may be at a disadvantage in terms of caregiver involvement in school, a critical aspect of early school success. Foster children are recruited in the spring before they enter kindergarten and randomly assigned to the intervention and comparison conditions. The KITS intervention includes three components: (a) child therapeutic play groups to facilitate the development of self-regulatory, social, and emergent literacy skills; (b) a psychoeducational support group to promote caregiver involvement in the child's emergent literacy and schooling and the use of effective parenting techniques; (c) home- and school-based behavioral consultation. The intervention coincides with the transition into kindergarten. Multi-method, multi-agent assessments of the children's socioemotional readiness and literacy skills are conducted at baseline, kindergarten entry, and postkindergarten. We will examine the direct effects of the intervention on school readiness and kindergarten outcomes. We will also assess whether intervention effects are mediated through mechanisms of stress reactivity and regulation and caregiver variables. Finally, we will test for moderator effects of child and contextual characteristics including early adversity (prenatal/neonatal health, maltreatment history and placement history), child cognitive functioning, and placement transitions during the course of the study. An additional exploratory aim of the study is to examine intervention effects on first and second grade outcomes for subsamples of children. Group comparisons and longitudinal growth modeling will allow for evaluation of hypotheses.
FIELD: medicine. SUBSTANCE: invention relates to biologically active addition showing adaptogenic effect that has oak acorns as a base; amaranthus, viburnum, burdock, mistletoe and rose seeds as enhancing substances, and bee honey as corrective addition in the following ratio: oak acorns, 1; enhancing substances, 0.4; corrective addition, 0.5. Prophylactic agent based on medicinal plants without their thermic treatment provides improvement function of pancreas and other blood glands, shows antiviral and antibacterial activity, normalizes metabolism based on synergistic effect and enhances immune defense system of human body from pathological effect of microorganisms, viruses and protozoan. Invention can be used for prophylaxis of diseases associated with metabolism disorders and for immunity enhancement. EFFECT: enhanced effectiveness of agent, valuable medicinal properties. 1 cl, 1 tbl
The present invention relates to a cationic lipid based aqueous formulation comprising cationic lipid, dexamethasone and a neutral co-lipid, wherein the said formulation is useful for selective targeting and delivering gene to glucocorticoid receptor expressing cancer cells. Glucorticoid receptors (GR) express in various normal and cancer cells. A lot of ligand activated physiological functions are known involving GR but its role in cancer progression (if any) is not clearly understood. Synthetic GR antagonist, dexamethasone (Dex) finds use as anti-inflammatory drug and is known to induce apoptosis in cancer cells. This Dex is included in a cationic lipid-based formulation as a co-lipid to deliver to and express genes specifically in cancer cells possibly through expressed GR. Gene delivery to cancer cells is independent of the gene construct, and tumor cell line. Normal transformed cells expressing GR but with no cancer lineage show much smaller level of transfection. The composition of the formulation is optimized. The formulation may have particular application to the enhanced delivery of anticancer genetic constructs to cancer, with the synergistic effect of Dex in inducing apoptosis as such.
BACKGROUND: Patients with persistent air leak (PAL) pose a therapeutic challenge to physicians, with prolonged hospital stays and high morbidity. There is little evidence on the efficacy and safety of bronchial valves (BV) for PAL.
METHODS: We systematically searched the PubMed and Embase databases to identify studies evaluating the efficacy and safety of BV for PAL. We calculated the success rate (complete resolution of air leak or removal of intercostal chest drain after bronchial valve placement and requiring no further procedures) of BV for PAL in individual studies. We pooled the data using a random-effects model and examined the factors influencing the success rate using multivariable meta-regression.
RESULTS: We analyzed 28 observational studies (2472 participants). The pooled success rate of bronchial valves in PAL was 82% (95% confidence intervals, 75 to 88; 95% prediction intervals, 64 to 92). We found a higher success rate in studies using intrabronchial valves versus endobronchial valves (84% vs. 72%) and in studies with more than 50 subjects (93% vs. 77%). However, none of the factors influenced the success rate of multivariable meta-regression. The overall complication rate was 9.1% (48/527). Granulation tissue was the most common complication reported followed by valve migration or expectoration and hypoxemia.
CONCLUSION: Bronchial valves are an effective and safe option for treating PAL. However, the analysis is limited by the availability of only observational data.
PCT No. PCT/FR88/00188 Sec. 371 Date Dec. 15, 1988 Sec. 102(e) Date Dec. 15, 1988 PCT Filed Apr. 19, 1988 PCT Pub. No. WO88/07986 PCT Pub. Date Oct. 20, 1988.Compound useful particularly for the treatment by targetted radiotherapy or imaging of cancer, characterized in that the compound is comprised of a molecule susceptible of fixing itself or passing close to the DNA of the target cells, said molecule being radiolabelled with iodine 123. The invention also relates to new ligands specific of steroid hormone receivers useful for the targetted therapy or imaging particularly of cancer and presenting a structural base skeleton having the formula (I). According to the invention these ligands comprise particularly a) a hydroxyl or ketone function in position C3; b) a  beta chloromethyl function on position C11; c) an  alpha  methyl or vinyl function on position C17 and d) a substituted radioactive iodine on an alkyl or alkenyl group attached to the skeleton, particularly methyl or vinyl.
The invention discloses a plaster for treating facial paralysis-caused eye-mouth deviation and realizing treatment on internal illness by external treatment, and a preparation method thereof. The plaster solves the problem that the existing drug produces effects slowly, has poor effects, causes pain in treatment and has a high cost. The plaster is prepared from Chinese starjasmine stem, Erodium stephanianum Willd, giant knotweed, tiger bone, corydalis tuber, leech, gadfly and cortex erythrinae soup by mixing. The plaster has the advantages of fast action, good treatment effects, no pain, no toxic or side effect, low cost and difficult recurrence after healing. The plaster has a scientific and practical formula. After use of the plaster in 24h, a virus liquid can be drawn and is shown for a patient. The one plaster can heal the child with the age of 2-15 in sleeping. One to three plasters can heal an adult and does not influence normal working and living in treatment.
The invention relates to a preparation method of an injection, particularly relates to a preparation method of an injection for treating male and female genital organ stubborn ills, male and female infertility, male and female sexual disorder, female chronic pelvic inflammatory disease and hyperplasia of mammary glands, and male prostatitis, prostatic hypertrophy and chronic pelvic pain. The injection is transparent injection prepared from Angelica sinensis by modern technology by distillation extraction of effective ingredients in volatile components and making into injection. The injection has effects of promoting blood circulation, softening hard masses, eliminating blood stasis, promoting tissue regeneration, restoring functions of visceral organs, and enhancing immunity. After application of the injection, male and female genital organs restore, and the treatment effect of male and female infertility and sexual disorder is apparently improved. The injection can regulate qi and blood balance of whole body, so as to achieve peculiar treatment effect on cardiovascular and cerebrovascular, digestive system, urinary system and skin stubborn ills, and cataract and hypertension. The injection is the first choice of treatment, prevention and health promotion. The injection has the characteristics of no toxic and adverse effect, is simple in application, integrates disease treatment and prevention and health promotion, and has more rapid therapeutic action than oral preparations.
A composition (e.g. a solution) for inhibiting hair growth in mammals which contains as the active ingredient a compound which block glucose transfer across the membranes of the cells of hair follicles. The compound is used in a method of inhibiting hair growth in mammals including topically applying the compound to any area of unwanted hair e.g. on a daily basis. A preferred embodiment of the invention uses phloretin as a glucose blocking compound. Other embodiments of the invention include steviol, cytochlasin B, 3,3'diallylstilbesterol and 3,3'-di(2-chlorallyl) stilbesterol. The blocking compounds are suspended in solutions of suitable solvents.
This invention relates to novel proteins useful for enhancing pulmonary surfactant activity, methods for obtaining said proteins and compositions containing one or more of the proteins. The proteins of this invention include the following: 1. A protein characterized by a molecular weight of about 35 kd and by being encoded for by the DNA sequence depicted in Table 1. 2. A protein characterized by a molecular weight of about 35 kd and by being encoded for by the DNA sequence depicted in Table 2. 3. A protein encoded for by a portion of the DNA sequence depicted in Table 6 and characterized by a molecular weight of about 5.5-9 kd; and 4. A protein characterized by a molecular weight of about 5.5-9 kd and an amino acid composition as set forth in Table 4.
Fibroblast growth factor 23 (FGF23) is a newly discovered hormone. Its primary function is to regulate phosphate metabolism, which it does both by directly regulating phosphate excretion through the kidney as well as by regulating vitamin D activity. What controls FGF23 levels is still under investigation; potential factors include dietary phosphate intake and vitamin D levels.

In this pilot study, we aim to investigate what the normal levels of FGF23 are in healthy girls and how these are related to other measurements of bone and mineral metabolism. Since vitamin D deficiency is very common in healthy girls, we expect a subset of the subjects in this study to be vitamin D deficient. We will then randomize these girls to vitamin D repletion or placebo and follow changes in FGF23 levels. Vitamin D deficiency has also been implicated in insulin resistance which is a precursor to diabetes. We will therefore also look at changes in insulin resistance with vitamin D repletion.
Dibutylaminoethyl ester of 4 - n - butylamino - 2 - hydroxy benzoic acid is prepared by heating a mixture of 4-n-butylamino-2-hydroxy-benzoic acid, p-toluene sulphonic acid and dibutylaminoethanol on a steam bath for 5 hours, making alkaline with potassium carbonate and extracting the ester so formed with ether. The hydrochloride is produced by dissolving the ester in hydrochloric acid.  Specifications 736,960 and 760,003 are referred to.ALSO:A pharmaceutical composition having activity against gram-negative bacteria, e.g. E. coli and B. proteus, comprises penicillin in admixture with a salt of an ester of general formula <FORM:0790300/VI/1> in which R1 and R2 are alkyl groups each containing 1 to 4 carbon atoms, X is hydrogen or a hydroxyl group, and R is an alkyl group containing 2 to 6 carbon atoms, the acid addition salt of the ester being present in an amount sufficient to increase the range of activity of the penicillin.  Esters specified are (a) dimethylaminoethyl ester of 4-n-butylamino-2-hydroxybenzoic acid; (b) diethylaminoethyl ester of 4 - n - butylamino - 2 - hydroxybenzoic acid; (c) dimethylaminoethyl ester of 4-n-butylamino-benzoic acid; and (d) dibutylaminoethyl ester of 4-n-butylamino-2-hydroxybenzoic acid. The hydrochloride is the preferred salt of these esters, but salts with tartaric acid, lactic acid or the sulphamic acid salt of p-aminosalicylic acid may be used. The penicillin may be any penicillin, penicillin G being preferred. The compositions may be used as aqueous solutions containing not more than 0.5 per cent of the ester salt.  Specifications 736,960 and 760,003, [both in Group IV (b)], are referred to.
Stroke is a neurological injury caused by the occlusion or rupture of cerebral blood vessels. Stroke can be ischemic, hemorrhagic, or both. Ischemic stroke is more frequently caused by arterial occlusion, but it may also be caused by venous occlusion of cerebral veins or sinuses. Hemorrhagic stroke is the result of bleeding from a ruptured cerebral artery or from bleeding into the site of an acute ischemic stroke. Stroke is relatively rare in children but can lead to significant morbidity and mortality. Understanding that children with strokes present differently than adults and often present with unique risk factors will optimize outcomes in children. Early recognition and treatment of pediatric stroke are critical in optimizing long-term functional outcomes, reducing morbidity and mortality, and preventing recurrent stroke. Neuroimaging plays a vital role in achieving this goal. Neuroimaging is usually the first step in diagnosis, helping discriminate between ischemic/hemorrhagic strokes and also in the identification of underlying potential causes MRI is a more sensitive test for early detection of an infarction. Magnetic resonance arteriography (MRA) and magnetic resonance venography (MRV) should also be carried out to confirm vessel patency and define the vascular anatomy. MRA will yield further information about blood flow, and MRV will more reliably identify cerebral venous sinus thrombosis. MRI has a high sensitivity and specificity in the first hours after symptom onset with the potential to both characterize the ischemic pathology and to differentiate ischemic from hemorrhagic lesions at least as accurately as computed tomography (CT). Most common imaging protocol used for acute ischemic stroke is an emergent/urgent stroke protocol MRI with MRA. This usually takes approximately 13 min for the MRI sequences and 19 min with MRA.
Disclosed is a method for preparing sustained release microparticles which release a physiologically active substance for long periods of time. The sustained release microparticles are prepared through a multi-emulsion process.      A drug of interest is dissolved or dispersed in each of at least two oils to give at least two primary oil phases or emulsions. Each oil phase or emulsion contains a biodegradable polymer. The least two primary oil phases or emulsions are dispersed in one aqueous phase, synchronously or in succession. From the drug-dispersed solution, the organic solvents are removed to produce microparticles.      Therefore, the drugs such as leutenizing hormone releasing hormones can be continuously released in vivo for prolonged periods of time, bringing about an improvement in the therapeutic effect.
The invention relates to the technical field of pneumonia prevention and treatment, and particularly relates to a traditional Chinese medicine formula for preventing pneumonia, a preparation method thereof and a traditional Chinese medicine card box. The traditional Chinese medicine formula comprises the following components: borneol, wormwood, rhizoma atractylodis, rhizoma acori graminei, radix angelicae, mint, biond magnolia flower, ligusticum wallichii, agastache rugosus and rhizoma cyperi, and the traditional Chinese medicine composition can be worn on the body to effectively prevent pneumonia without oral administration, and avoids discomfort of people caused by oral administration prevention. The preparation method of the traditional Chinese medicine formula comprises the following steps: weighing folium Artemisiae Argyi, rhizoma Atractylodis, rhizoma Acori Graminei, radix Angelicae Dahuricae, herba Menthae, flos Magnoliae, rhizoma Ligustici Chuanxiong, herba Agastaches and rhizoma Cyperi, cleaning, oven drying, adding Borneolum Syntheticum, mixing, and grinding into powder; filling the pulverized Chinese medicinal mixture into Chinese medicinal bag with several air-dispersing holes for volatilizing medicine. The preparation method is simple and low in cost. The traditional Chinese medicine card box comprises a card box body, wherein air holes are formed in the card box body, and the card box body comprises a storage cavity for storing traditional Chinese medicine bags. It can be convenient for the wearing of medicine, and it is more convenient to use.
This study analyzes the relationship between work fatigue and musculoskeletal disorders in gas station operators in Pontianak City. This study used with a cross-sectional approach. The sample consists of 150 gas station workers. Data collection was carried out by observing and interviewing. Respondents characteristics were recorded through interviews using a questionnaire. Data on work fatigue were obtained by interviews using the IFRC questionnaire and musculoskeletal data using the Nordic Body Map questionnaire. The study results show that 50% of workers experience a high level of work fatigue, and 26% of workers experience severe musculoskeletal disorders. There is a significant relationship between work fatigue and musculoskeletal diseases (p = 0.001). The study established the need for intervention as a preventive measure by providing sufficient rest time, stretching, setting work shifts, improving ergonomic work positions for gas station operators, and controlling the work environment through environmental improvement and monitoring and using personal protective equipment.
Participants will receive spinal manipulative therapy (SMT) exclusively at dysfunctional lumbar segments. Participants will receive 36 SMT sessions over 12 weeks, 3 times per week, each session lasting ≈15 min. Spinal manipulation will be performed using the diversified technique. For each treatment, the SMT provider will perform two spinal manipulations, one on each side of the most painful lumbar vertebra. During spinal manipulations, participants will lay on their side and they will be instructed to inhale and exhale fully before each thrust.
Type 1 diabetes (T1D) is a chronic autoimmune disease that is caused by a combination of genetic and environmental risk factors. In this study, we sought to determine whether a known genetic risk factor, the rs1990760 single nucleotide polymorphism (SNP) (A946T) in IFIH1, resulted in a gain of function in the MDA5 protein and the effects of this mutation on the regulation of type I IFNs during infection with the diabetogenic virus coxsackievirus B3. We found that in cell lines overexpressing the risk variant IFIH1946T there was an elevated level of basal type I IFN signaling and increased basal IFN-stimulated gene expression. An investigation into the mechanism demonstrated that recombinant MDA5 with the A946T mutation had increased ATPase activity in vitro. We also assessed the effect of this SNP in primary human PBMCs from healthy donors to determine whether this SNP influenced their response to infection with coxsackievirus B3. However, we observed no significant changes in type I IFN expression or downstream induction of IFN-stimulated genes in PBMCs from donors carrying the risk allele IFIH1946T. These findings demonstrate the need for a deeper understanding of how mutations in T1D-associated genes contribute to disease onset in specific cellular contexts.
Matching placebo will be administered orally once daily on a continuous schedule. All subjects will receive background therapy with BR for a maximum of 6 cycles (a cycle is defined as 28 days, with the exception of Cycle 1, which will be 29 days to allow for rituximab dosing prior to bendamustine and study medication).
There are currently 5 million active high school, collegiate, professional, and master athletes in the United States. Regular intense exercise by these athletes can promote structural, electrical and functional remodeling of the heart, which is termed the "athlete's heart." In addition, regular intense exercise can lead to pathological adaptions that promote or worsen cardiac disease. Many of the athletes in the United States seek medical care. Consequently, physicians must be aware of the normal cardiac anatomy and physiology of the athlete, the differentiation of the normal athlete heart from the athlete with cardiomyopathy, and the contemporary care of the athlete with a cardiomyopathy. In athletes with persistent cardiovascular symptoms, investigations should include a detailed history and physical examination, an ECG, a transthoracic echocardiogram, and in athletes in whom the diagnosis is uncertain, a maximal exercise stress test or a continuous ECG recording, and cardiac magnetic resonance imaging or cardiac computed tomography angiography when definition of the coronary anatomy or characterization of the aorta and the aortic great vessels is indicated. This article discusses the differentiation of the normal athlete with physiologic cardiac remodeling from the athlete with hypertrophic, dilated or arrhythmogenic ventricular cardiomyopathy (ACM). The ECG changes in trained athletes that are considered normal, borderline, or abnormal are listed. In addition, the normal echocardiographic measurements for athletes who consistently participate in endurance, power, combined or heterogeneous sports are enumerated and discussed. Algorithms are listed that are useful in the diagnosis of trained athletes with borderline or abnormal echocardiographic measurements suggestive of cardiomyopathies along with the major and minor criteria for the diagnosis of ACM in athletes. Thereafter, the treatment of athletes with hypertrophic, dilated, and arrhythmogenic right ventricular cardiomyopathies are reviewed. The distinction between physiologic changes and pathologic changes in the hearts of athletes has important therapeutic and prognostic implications. Failure by the physician to correctly diagnose an athlete with hypertrophic cardiomyopathy, dilated cardiomyopathy, or ACM, can lead to the sudden cardiac arrest and death of the athlete during training or sports competition. Conversely, an incorrect diagnosis by a physician of cardiac pathology in a normal athlete can lead to an unnecessary restriction of athlete training and competition with resultant significant emotional, psychological, financial, and long-term health consequences in the athlete.