anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Zirconium silicate particles mixed in three distinct size ranges, namely (I) up to 20 m , (II) 20 m -50 m  and (III) over 50 m  wherein not more than 2% by wt. are over 70 m  form the essential ingredient in dental prophylaxis compositions. Preferably, the zirconium silicate particles have a rough surface produced by hammer milling attrition and the mixture comprises 10-50% by wt. in range I, 5-25% in range III, and the balance in range II, not more than 25% being less than 10 m .ALSO:A dental prophylaxis composition comprises as its essential ingredient zirconium silicate which is a mixture of particles in three distinct size ranges, namely (I) up to 20m , (II) 20m -50m  and (III) over 50m  wherein not more than 2% by wt. are over 70m . Preferably the particles have a rough surface produced by hammer milling attrition and the mixture comprises 10-15% by wt. in range I, 5-25% in range III and the balance in range II, not more than 25% being less than 10m .  Generally the zirconium silicate is used in the form of an aqueous slurry containing 15-25 parts by weight of water per 100 parts zirconium silicate powder in a conventional prophylaxis composition.
The method of reducing the drying time of nail varnish comprises introducing cellulose ester as component of nail varnish composition.   Cellulose ester is used in a nail varnish composition, comprising, in solvent medium, a polymeric system containing at least 50 wt.% of nitrocellulose (per total wt. of nitrocellulose and cellulose ester), film-forming auxiliary polymer and colorant. Cellulose ester is used in effective and synergic quantity (relative to nitrocellulose content) to reduce drying time of varnish. Solvent medium preferably contains at least one organic solvent. The composition preferably contains at least one plasticizer, and does not contain silicone drying agent.
Background. Cannabis is the most widely used illicit substance in the whole Western world and rates are further rising. Almost 240.000 adult Germans fulfill DSM-IV criteria for cannabis dependence and 140.000 the criteria for cannabis abuse (past 12-month), respectively. Several studies have revealed a considerable degree of unmet needs for intervention and treatment for cannabis disorders, for example in terms of associated physical, mental health, social and legal problems. The epidemiological significance of the problem is contrasted sharply with (1) strongly increasing treatment demand due to cannabis-related problems, (2) the lack of evidence-based interventions (motivational and early treatment) (3) the lack of specific services, and (4) the lack of treatment programs and components with established efficacy. With regard to treatment research there is a marked deficit with only a handful of studies up to date. Only in the US and Australia, some recent effort was undertaken to develop and evaluate cannabis-specific dependence treatment programs in controlled trials with highly selective samples. However, there are currently no 'state of the art' benchmark programs neither in Germany nor in other European countries that are suitable for routine use.

Aims. (1) To develop a modular treatment program (ST/TST) for cannabis use disorders based on treatment packages and components that have been shown to be effective in previous US and Australian trials, and to adapt these material to the needs of our target population. (2) To demonstrate that this modular treatment package, implying motivational enhancement, cognitive-behavioral and psychosocial problem solving components is efficacious in comparison to a delayed treatment control (DTC) group. (3) Additionally, we test whether the targeted standardized treatment (TST) component tailored to address more specifically core problem areas results in superior short term (3-months) outcomes in these core domains as compared to the ST-group.

Method. A randomized controlled intervention study is proposed. A total of 210 participants will be randomly assigned to two, respectively three study conditions: 1. ST (n=70) including motivational enhancement, cognitive-behavioral, and psychosocial problem solving treatment components, 2. TST (n=70), including the same components as the ST but partly individually matched to the specific problem profile of the patient, and (c) a delayed treatment control group (DTC, n=70). Core outcome variables are total quit rates, number of cannabis use in the past 4 weeks, decrease in ASI scores and retention rate. The core hypothesis will be tested in the combined ST/TST group (n=140). The ASI serves for the allocation algorithms in the TST group and serves as outcome measure for the 3rd hypothesis.

The proposed study is innovative and will result in a considerable advancement of our knowledge about effective treatments in cannabis disorders and will inform about the value of targeted individualized allocation.
Obesity and gestational diabetes (GDM) impact fetal growth during pregnancy. Iron is an essential micronutrient needed for energy-intense feto-placental development, but if mis-handled can lead to oxidative stress and ferroptosis (iron-dependent cell death). In a mouse model showing maternal obesity and glucose intolerance, we investigated the association of materno-fetal iron handling and placental ferroptosis, oxidative damage and stress signalling activation with fetal growth. Female mice were fed a standard chow or high fat, high sugar (HFHS) diet during pregnancy and outcomes were measured at day (d)16 or d19 of pregnancy. In HFHS-fed mice, maternal hepcidin was reduced and iron status maintained (tissue iron levels) at both d16 and d19. However, fetal weight, placental iron transfer capacity, iron deposition, TFR1 expression and ERK2-mediated signalling were reduced and oxidative damage-related lipofuscin accumulation in the placenta was increased in HFHS-fed mice. At d19, whilst TFR1 remained decreased, fetal weight was normal and placental weight, iron content and iron transporter genes (Dmt1, Zip14, and Fpn1) were reduced in HFHS-fed mice. Furthermore, there was stress kinase activation (increased phosphorylated p38MAPK, total ERK and JNK) in the placenta from HFHS-fed mice at d19. In summary, a maternal HFHS diet during pregnancy impacts fetal growth trajectory in association with changes in placental iron handling, ferroptosis and stress signalling. Downregulation of placental iron transporters in HFHS mice may protect the fetus from excessive oxidative iron. These findings suggest a role for alterations in placental iron homeostasis in determining perinatal outcomes of pregnancies associated with GDM and/or maternal obesity.
BA accounts for approximately 60% of the liver transplantations in infants younger than 1 year of age. The diagnosis of BA remains a clinical challenge because affected neonates have signs, symptoms, and serum liver biochemistry that are also seen in those with other causes of neonatal cholestasis.

The success of the Kasai procedure is varied, but a good outcome is correlated with an early diagnosis. Unfortunately, most BA are usually identified later and the average age at surgery is about 60 days. To address this problem, some research groups screen infants for the pale stools or measure bilirubin level in the serum. However, these screening programs have not yet to be implemented because of several reasons. Recently, the relative abundance of serum MMP-7 was suggested to have discriminatory features for infants with BA. Nevertheless, whether the level of MMP-7 elevates in newborn dry blood spot of BA is still undefined. In this study, we will explore a screening strategy based on DB, γ-GT or MMP-7 measurement in newborn screening blood spot, and identify whether DB , γ-GT or MMP-7 measurement in the newborn period could be sensitive and specific for BA.
PROBLEM TO BE SOLVED: To obtain an agent for hepatic failure useful for prevention and remedy or various kinds of hepatic failures such as virus hepatitis, alcoholic hepatic injury, and drug induced hepatic injury by including an extract of Spondylus varius Sowerby as an active ingredient. SOLUTION: This agent for hepatic failure contains an extract of Spondylus varius Sowerby as an active ingredient. The raw material for the extract is Spondylus varius Sowerby, Spodylidae, Pteriomorphia of Bivalvia, living in south sea such as Okinawa area, and its close species. The extract is obtained by extracting the raw material by using a solvent, and optionally partially purifying the obtained extract. If necessary, the obtained extract can be subjected to means such as condensation, liquid-liquid distribution, and adsorption chromatography. The extract can be used as a medicine, and also allowed to be included in a functional food.
The invention discloses an anti-pancreatic cancer monoclonal antibody and an application thereof. A hybridoma cell strain NM002-1 excreting the anti-human pancreatic cancer monoclonal antibody is preserved in the China Center for Type Culture Collection on August 31, 2011, and has a preservation number of CCTCC NO:C201173. The hybridoma cell strain NM002-1 secrets the anti-human pancreatic cancer monoclonal antibody NJ002-1. The expression of a specific antigen of the monoclonal antibody NJ002-1 disclosed by the invention in pancreatic cancer tissues is higher than that in pancreas benign disease tissues, and the positive expression rate of the antigen in a poorly differentiated patient is higher than that in a highly differentiated patient. Moreover, the monoclonal antibody NJ002-1 can effectively inhibit the clone formation of pancreatic cancer cells SW1990 in soft agar, and can significantly inhibit the growth of a human pancreatic cancer transplantation tumor in the body of a nude mouse. Therefore, the monoclonal antibody NJ002-1 is expected to become a medicament for treating pancreatic cancer or be prepared into a diagnostic reagent for detecting the pancreatic cancer.
Patients undergo IMPT for 15 sessions over 19 days in the absence of disease progression or unacceptable toxicity. Patients may receive cisplatin IV over 1-2 hours per standard of care. Patients undergo CT or MRI and PET/CT or PET/MRI during screening and follow-up. Patients may also undergo blood sample collection throughout the trial.
Cognitive impairments are closely associated with depression and recent studies have found that these cognitive problems can persist following remission of depression. Internet-delivered cognitive control training (CCT), and the adaptive Paced Auditory Serial Addition Task (aPASAT) in particular, has shown to be an effective preventative intervention for remitted depressed individuals (RMD), where beneficial effects have been found for rumination, depressive symptomatology (Hoorelbeke \& Koster, 2017), and risk for recurrence of depression (Hoorelbeke et al., 2021). At the same time, prior studies suggest significant heterogeneity in response to CCT, where RMD individuals can show strong fluctuations in functioning in the months following completion of aPASAT training. In line with this, recent findings suggest that, for individuals with high-risk profiles, initial training gains may diminish over time, resulting in recurrence of internalizing symptomatology (Hoorelbeke et al., 2022). As such, there may be merit in the use of CCT booster sessions.

Currently, it is unclear whether offering additional CCT sessions when RMD individuals are reporting increased symptomatology (i.e., adding booster sessions based on early warning signs for possible recurrence of depression) can increase the long-term effectiveness of CCT. In this study, two groups of RMD individuals will perform 10 CCT sessions, after which one group will be offered booster sessions (contingent on indicators of functioning). For this purpose, we will rely on 15 weekly mobile assessments, using the PHQ-9 questionnaire. In addition, functioning will be assessed using a more extensive assessment battery at baseline, post-training (2 weeks after baseline) and follow-up (15 weeks after baseline).
PURPOSE: A composition containing Chinese herbal medicine for treatment of gray hair and premature gray hair is provided which has an effect on nourishing the blood and strengthening the body while treating gray hair. CONSTITUTION: About 400g Rehmanniae Radix is mixed with 100ml liquor, 400g Zingiberis Rhizoma Crudus, 250g Amomi Semen and 250g Ligustrum japonicum to produce a first mixture. About 300g Polygoni Multiflori Radix is mixed with 300g Pleuropterus multiflorus, 300g Cuscutae Semen, 300g Glycine max L. Merr., 300g Glycine max L. Merr. and 100ml liquor to produce a second mixture. About 400g black sesame is mixed with 300g Lycii Radicis Cortex, 350g Liriopis Tuber, 200g Moutan Cortex Radicis, 200g Ostreae Testa, 200g Cinnamomi Ramulus, 250g Fossilia Ossis Mastodi, 300g Angelicae Gigantis Radix, 250g Cnidii Rhizoma and 300g Atractylodis Rhizoma to produce a third mixture. All the above mixtures are mixed and formed.
PURPOSE:A hair cosmetic not only preventing white hair and making it black but also showing light promoting action on occurrence of hair, obtained by using an essence extracted from Acanthopanax spinosus Miq. as a main agent, blending it with a proper compounding agent. CONSTITUTION:An essence extracted from Acanthopanax spinosus Miq. well- known as a herb medicine for long is used as a main agent, further preferably blended with one or more of essence extracted from herb and chemical substances (carpronium chloride, nicotinic acid, nicotinic acid derivative, pilocarpine, etc.), to give a hair cosmetic preventing white hair, making it black, promoting occurrence of hair. Further addition of essence extracted from Japanese swertia such as swertiol is preferable.
Participants with Diet-controlled Type 2 Diabetes who were assigned to Open-label treatment with colchicine. These participants were not randomized and were not part of the randomized controlled trial.
While the relationships between spectral resolution, temporal resolution, and speech recognition are well defined in adults with cochlear implants (CIs), they are not well defined for prelingually deafened children with CIs, for whom language development is ongoing. This cross-sectional study aimed to better characterize these relationships in a large cohort of prelingually deafened children with CIs (N = 47; mean age = 8.33 years) by comprehensively measuring spectral resolution thresholds (measured via spectral modulation detection), temporal resolution thresholds (measured via sinusoidal amplitude modulation detection), and speech recognition (measured via monosyllabic word recognition, vowel recognition, and sentence recognition in noise via both fixed signal-to-noise ratio (SNR) and adaptively varied SNR). Results indicated that neither spectral or temporal resolution were significantly correlated with speech recognition in quiet or noise for children with CIs. Both age and CI experience had a moderate effect on spectral resolution, with significant effects for spectral modulation detection at a modulation rate of 0.5 cyc/oct, suggesting spectral resolution may improve with maturation. Thus, it is possible we may see an emerging relationship between spectral resolution and speech perception over time for children with CIs. While further investigation into this relationship is warranted, these findings demonstrate the need for new investigations to uncover ways of improving spectral resolution for children with CIs.
Manual cataract surgery will be performed. Aqueous humour will be collected and frozen in -80° celsius before MCS starts.
Recurrent abdominal pain is the most common type of pain in school age children and young adolescents. Over 80% of these children have pain in the upper abdomen which is diagnosed as functional dyspepsia (FD). Many of these children are also found to have eosinophilic duodenitis (ED). ED is a type of inflammation in the lining of the gastrointestinal tract characterized by an increase in eosinophils. An increase in intestinal eosinophils is a finding also seen with food allergy upon exposure to the offending antigen. The presence of intestinal eosinophilia in ED would suggest an allergic mechanism may be involved in the generation of pain and other symptoms associated with ED. Endoscopy and biopsy are used to aid in the identification of ED, which often is followed by elimination diets and food challenges to identify the offending allergen. This approach is both invasive (due to endoscopy) and cumbersome (due to the complexity and restrictiveness of the elimination diet). The value of screening for food hypersensitivities in children with ED has not been well characterized despite the theoretical links between food hypersensitivities, gut inflammation, and symptoms of dyspepsia. The current study will determine if standard and investigational tests used to evaluate food hypersensitivity have the potential to be used as biomarkers to direct treatment of children with ED.
<P>PROBLEM TO BE SOLVED: To provide a data intensive collection management system for performing a useful static analysis for the medical condition of a patient, and presenting the result.  <P>SOLUTION: Both a server device and a terminal device comprise communication means, so that transmission data can be intensively collected in the server device, and accumulated by an accumulation means. The server device further comprises a data analyzing means so that various statistic analyses for the medical condition of the patient can be performed by use of the thus- accumulated analyzing transmission data, and the analytic result can be presented to the terminal device. Both the server device and the terminal device further comprise encrypting and decoding means for performing the secrete processing of personal information, so that the outflow of the part requiring the privacy protection of the data exchanged between the terminal device and the server device can be prevented, and the information necessary for analysis can be disclosed. Further, the server device comprises an accumulated data control means, so that only precise data can be accumulated in the accumulation means to perform a precise statistic analysis in the analyzing means.  <P>COPYRIGHT: (C)2003,JPO
The high-volume irrigation system consists of an irrigation bag connected to a tube. The water flows into the rectum, either by gravity or by using a pump. Some systems use balloon to hold the device in place during irrigation; others require the user to hold it in place. The mechanism of action is the same for all systems. Participants will start irrigation with 300ml and increase this by 100ml every 2 days until satisfactory defaecation is achieved, or the procedure becomes uncomfortable, up to a maximum of 1500ml. Initial frequency of irrigation is the same as for low-volume irrigation: i.e. once daily for two weeks followed by participant adjustment of number of irrigation days per week as well as volume used for irrigation but no more than 1500ml a day. Participants will be restricted to using high-volume irrigation to not more than once a day.
The use of intravenous antiplatelet therapy during primary percutaneous coronary intervention (PPCI) is not fully standardized. The aim is to evaluate the effectiveness and safety of periprocedural intravenous administration of cangrelor or tirofiban in a contemporary ST-segment elevation myocardial infarction (STEMI) population undergoing PPCI. This was a multicenter prospective cohort study including consecutive STEMI patients who received cangrelor or tirofiban during PPCI at seven Italian centers. The primary effectiveness measure was the angiographic evidence of thrombolysis in myocardial infarction (TIMI) flow < 3 after PPCI. The primary safety outcome was the in-hospital occurrence of BARC (Bleeding Academic Research Consortium) 2-5 bleedings. The study included 627 patients (median age 63 years, 79% males): 312 received cangrelor, 315 tirofiban. The percentage of history of bleeding, pulmonary edema and cardiogenic shock at admission was comparable between groups. Patients receiving cangrelor had lower ischemia time compared to tirofiban. TIMI flow before PPCI and TIMI thrombus grade were comparable between groups. At propensity score-weighted regression analysis, the risk of TIMI flow < 3 was significantly lower in patients treated with cangrelor compared to tirofiban (adjusted OR: 0.40; 95% CI: 0.30-0.53). The risk of BARC 2-5 bleeding was comparable between groups (adjusted OR:1.35; 95% CI: 0.92-1.98). These results were consistent across multiple prespecified subgroups, including subjects stratified for different total ischemia time, with no statistical interaction. In this real-world multicenter STEMI population, the use of cangrelor was associated with improved myocardial perfusion assessed by coronary angiography after PPCI without increasing clinically-relevant bleedings compared to tirofiban.
Dimensionally-true sintering or thorough sintering of a milled molded article processed from a blank (10) including a green body or a pre-sintered blank body, preferably dental reconstruction e.g. bridge (12), comprises: connecting the molded article with a carrier body (14) together with the article via a first web-like connection; and arranging the article on a carrier (32) during the sintering. The article is processed with a curved-shaped geometry. The carrier body is processed along a concave area of the article so that it exhibits a first limiting surface and a second limiting surface. Dimensionally-true sintering or thorough sintering of a milled molded article processed from a blank (10) including a green body or a pre-sintered blank body, preferably dental reconstruction e.g. bridge (12), comprises: connecting the molded article with a carrier body (14) together with the molded article processed from the blank via a first web-like connection; and arranging the molded article on a carrier (32) during the sintering or the thorough sintering. The molded article is processed with a curved-shaped geometry from the blank. The carrier body is processed along a concave area of the molded article in such a manner that it exhibits a first limiting surface of the curved-shaped geometry extending into a molded article side, and a second limiting surface of a plane-shaped geometry extending in an opposite side of the molded article. The second limiting surface is arranged on the carrier forming a rigid support during the sintering or the thorough sintering.
The invention relates to a Baicao expandable vaginal suppository for clearing gynecologic inflammation, and a preparation method and a detection method thereof. The expandable suppository comprises a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition and the matrix form a medicine-containing matrix, which is coated on the surface of the expansion carrier. The traditional Chinese medicine composition is prepared from sophora root, the tuber of stemona, Fructus Cnidii, agrimony, Folium Callicarpae Formosanae, alum, borneol, camphor and boric acid; and the medicine-containing matrix includes an acidifier and hydrogenated lecithin, which cooperate to promote absorption of the traditional Chinese medicine composition. The expandable vaginal suppository is prepared into an osmotic pump expandable vaginal suppository, which has the function of zero level slow release, so as to fully play the therapeutic effect of the expandable suppository. And the Baicao expandable vaginal suppository employs seven unique technologies, and has the beneficial effects of prevention of outflow liquid, high stability, lasting effect and prevention of secondary infection.