anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pathogenic variants in genes encoding ion channels are causal for various pediatric and adult neurological conditions. In particular, several epilepsy syndromes have been identified to be caused by specific channelopathies. These encompass a spectrum from self-limited epilepsies to developmental and epileptic encephalopathies spanning genetic and acquired causes. Several of these channelopathies have exquisite responses to specific antiseizure medications (ASMs), while others ASMs may prove ineffective or even worsen seizures. Some channelopathies demonstrate phenotypic pleiotropy and can cause other neurological conditions outside of epilepsy. This review aims to provide a comprehensive exploration of the pathophysiology of seizure generation, ion channels implicated in epilepsy, and several genetic epilepsies due to ion channel dysfunction. We outline the clinical presentation, pathogenesis, and the current state of basic science and clinical research for these channelopathies. In addition, we briefly look at potential precision therapy approaches emerging for these disorders.
National prescription rates for low-value antibiotics for uncomplicated upper respiratory infections (URIs) remain unacceptably high, including at LAC+USC Medical Center-one of the largest safety net medical centers in the U.S. Using a quasi-experiment (pre-post) design, antibiotic prescriptions for URI at LAC+USC Urgent Care Center (intervention site) vs. Olive View-UCLA Urgent Care Center (control site) will be compared. A three-part intervention at LAC+USC consists of (1) the urgent care medical director emailing Choosing Wisely® guidelines and presented journal club to all 16 urgent care clinicians, and then (2) leveraging EHR performance data to provide individual clinicians with case-specific audit-feedback (both via emails and in-person while precepting nurse practitioners) on low-value antibiotic prescribing, and (3) using a behavioral "nudge", urgent care clinicians will sign a large poster committing to avoid prescribing low-value antibiotics for uncomplicated URIs, which will be displayed in the clinic. In contrast, the control site (Urgent Care Center at Olive View-Medical Center) will receive Centers for Disease Control prescription pads for non-antibiotic treatments (e.g., decongestants) that offer patients alternatives to antibiotics, in a broader health system effort to reduce antibiotic prescribing. Patient with URIs (e.g., acute bronchitis, bronchitis NOS, excluding guideline-based red flags such as COPD, HIV) will be identified using electronic health record clinical billable data and low-value antibiotic prescriptions rates per visit will be monitored at both sites. Differences in prescriptions rates will be determined using an interrupted time-series analysis comparing utilization between sites using a repeated measures logistic regression model.

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PROBLEM TO BE SOLVED: To obtain a cosmetic excellent in dispersibility and stability, hardly being influenced by pH, even in a system formulated especially with an acidic substance, having a low pH, high in phosphatidyl choline content, by including a specific amount of an acidic phospholipid. SOLUTION: This cosmetic has >=70wt.% of phosphatidyl choline content and comprises phosphatidyl choline and an acidic phospholipid (e.g. phosphatidyl inositol) in the weight ratio of 99.9:0.1 to 95:5. Preferably, the cosmetic contains a cholesterol and/or its derivative (e.g. dihydrocholesterol) and is adjusted to pH<=5. The blending ratio of the phospholipid and the cholesterol and/or its derivative by weight is preferably in a range of 1:0.1 to 1:1.
This treatment group will receive a combination therapy (i.e., both laser and physiotherapy), with each session lasting up to 50 minutes over a 12 week period. Laser and physiotherapy treatments will be delivered within the same visit where possible. Laser and physiotherapy protocols will be delivered as described in the previous arms.
PURPOSE:To provide a make-up cosmetic such as mascara, eye liner or foundation, containing a specified amount of an oil-soluble resin in the outer layer and a material for coloring in the inner layer, excellent in water resistance, perspiration resistance, sebum resistance, oil resistance, etc., and exhibiting an excellent make-up durability. CONSTITUTION:This water in oil type make-up cosmetic contains 1 to 54wt.% (especially preferably 5 to 50wt.% from the viewpoint of water resistance and oil resistance) oil-soluble resin in the outer layer and a material for coloring (e.g. talc, mica or kaolin) in the inner layer (aqueous layer). As the oil-soluble resin, an organic silicone resin [e.g. a compound satisfying (CH3)3SiO1/2: SiO2=1.5/1] composed of a structural unit of formula I [R is a 1 to 6C hydrocarbon or phenyl; (n) is 1.0 to 1.8] as the average formula is used. In this cosmetic, about 40 to 98wt.% volatile oil component {e.g. organic silicone oil of formula II [(n) is 0 to 3]} is recommendably blended in addition to the oil-soluble resin. The coating film of the outer layer of this make-up cosmetic is kept in a continuous state and the material for coloring is contained in the inner layer. Since material for coloring is prevented from coming into contact with the outside atmosphere, the make-up durability is excellent.
Participants received a 12-hour intravenous (IV) infusion of SAGE 547, at ascending doses of 29, 58, and 86 micrograms per kilogram of body weight per hour (μg/kg/h), 4 hours each, on Day 1 of Stage 1 \[Treatment Period 1 (TP 1)\]. After a washout period of approximately 7 days, participants received a 12-hour IV infusion of SAGE-547 matching-placebo, on Day 10 of Stage 1 \[Treatment Period 2 (TP 2)\].
The trial is designed as a multicenter randomized single blinded study with the centralized blinded outcome assessment. The patients with diagnosed STEMI will be randomly assigned with one of the treatment options within 4 hours after the symptoms onset. The effectiveness of the tested product GNR-060 or reference product Metalyze will be assessed by the coronarography within 24 hours after the thrombolysis with the following PCI in case of ineffectiveness. The patients will then be followed up for survival and cardiac events for 90 days. The safety assessment will also include any related hemorrhagic complication. The pharmacokinetic parameters and immunogenicity will be also assessed.
The study finds no significant difference in the timing of radiation therapy initiation between bleeding and non-bleeding cohorts, ensuring that timely adjuvant care is achievable without compromising survival. Feeding tube dependency and dysphagia outcomes are also explored to enhance understanding of post-surgical morbidity and quality of life. With a multi-institutional design, the study strengthens the generalizability of its findings and addresses limitations inherent in retrospective data collection. Future research could use validated patient-reported outcomes to refine swallowing assessments and investigate novel hemostatic techniques as alternatives to transcervical arterial ligation. Additionally, exploring HPV-related prognostic subgroups will provide further clarity on oncological outcomes. This study paves the way for optimizing TORS protocols to improve patient care and long-term survival.
The invention relates to a bone-growth and intelligence-development ginseng antler capsule, which is a medicament for mainly treating short stature and mental retardation of adolescents and children in a growth and development step. The capsule provided by the invention has advantages of good treatment effects, short treatment process, safe facilitation, intelligence development, simpleness and convenience, no pains and no toxic and side effects. The capsule provided by the invention comprises the following raw materials: red ginseng, pilose antler, seal kidney, placenta, aspongopus chinensis dallas, cordyceps sinensis, cistanche deserticola, semen cuscutae, os draconis, oyster, tortoise plastron, fructus lycii, spina date seed, radix polygalae, schisandra chinensis, radix rehmanniae, radix rehmanniae preparata, atractylodes macrocephala, Indian buead, acorus tatarinowii schott, hawthorn, endothelium corneum gigeriae galli, and liquorice. According to the theory of kidney governing bones to control Qi, produce marrow and develop intelligence in the traditional Chinese medical science, the capsule can be used for intelligence development by reinforcing kidney, supplementing essence and producing the marrow. Meanwhile, the bone-growth and intelligence-development ginseng antler capsule is used for benefiting essential Qi through mental-tranquilization, immobilization, spleen invigoration and Qi replenishment, and appetite stimulation, thereby improving abilities of tonifying the kidney to supple the essence, producing the marrow and developing the intelligence. Due to brain being marrow sea and bones being the marrow, if the marrow is enough, a person is smart and invigorating, and the bones grow; in addition, if the essence is enough, the hair is black, the hearing is quick, the action is sensitive, and the intelligence is strong, and therefore the purposes of the bone growth and the intelligence improvement and development are realized.
The invention relates to medicine, in particular to radiology, and may be used in oncology and mammology. The invention is aimed at facilitating breast cancer diagnostics. The breast cancer diagnostics method includes contrast enhanced spectral mammography with an additional delayed phase included in the imaging protocol - contrast enhanced spectral mammography imaging at the 9-12th minute from the beginning of intravenous injection of a contrast agent. The contrast enhanced spectral mammography was carried out using Senographe Essential digital mammography system (GE) with a contrast enhanced spectral mammography (CESM) function - obtaining immediate recombinant imaging. A iodine-containing contrast agent with 300 mg/ml iodine concentration was used as a contrast agent and was introduced intravenously at a rate of 3 ml/sec on the basis of 1.5 ml/kg of weight, but max. 100 ml. Biplane mammograms were made after introduction of the iodine-containing contrast agent to the patient: craniocaudal (CC) and mediolateral (MLO), in the interval from 2 to 5 min and from 9 to 12 min from the beginning of the contrast agent introduction. Compression time for each breast was not more than 15 sec. Processed recombinant images were transferred directly to a workstation for interpreting by a mammography radiotherapist. The total effective dose equivalent varied from 1.4 to 3.6 mGy depending on the size and structural type of the breast. The proposed method makes it possible to improve breast cancer diagnostics, to determine more precisely dimensions, location and prevalence (nodal, multifocal, multicentric, inflammatory growth forms) of the main process, the positive predictive value of the method was 97.7%.
Mixed martial arts' popularity has increased in recent years, alongside descriptive research and evidence-based performance recommendations. Guidelines for (both chronic and acute) weight making exist; however, how these translate in real-life scenarios and detailed investigations on practices in larger groups deserve attention. The present study examined the body mass (BM) and composition of 33 professional mixed martial arts athletes preparing for 80 fights. Athletes were supported by on-site dietitians, who encouraged evidence-based practices. Fasted BM was measured throughout the last ∼10 days before all bouts (acute weight management phase). A subset of athletes had body composition assessed before and after the chronic weight loss phase for 40 fights. Most athletes engaged in chronic BM loss, and all engaged in acute weight loss. Many lost fat-free mass (FFM) during the chronic phase, with rates of BM loss <0.5% best preserving FFM. Regardless of losses, the present athletes possessed greater FFM than other combat sport athletes and engaged in greater acute weight loss. Dehydration in the 24-48 hr before the weigh-in was not reflective of weight regain after the weigh-in, rather BM 7-10 days before the weigh-in was most reflective. These findings suggest that many mixed martial arts athletes could increase FFM at the time of competition by maintaining leaner physiques outside of competition and/or allowing increased time to reduce BM chronically. Acutely, athletes can utilize evidence-based protocols, eliminating carbohydrates, fiber, sodium, and finally fluid in a staged approach, before the weigh-in, reducing the amount of sweating required, thus theoretically better protecting health and preserving performance.
PCT No. PCT US88/04208 Sec. 371 Date Apr. 26, 1990 Sec. 102(e) Date Apr. 26, 1990 PCT Filed Nov. 23, 1988.The invention is a sustained release dosage or delivery form, such as a tablet, pill, granule or the like capable of providing sustained release of a functionally active ingredient and the method for its manufacture. The invention comprises a matrix of a polymer containing functionally active ingredient and an excipient shaped at or above the glass transition temperature of said polymer into a form such as a granule, tablet or the like. Preferably the excipient is a microcrystalline cellulose.
Combination arm - Trabectedin + DOXIL: DOXIL 30 mg/m2 intravenous (IV) infusion over 90 minutes + trabectedin 1.1 mg/m2 IV infusion over 3 hours every 3 weeks. patients will be premedicated with 20 mg dexamethasone or its equivalent IV infusion over 30 minutes prior to the DOXIL infusion.
BACKGROUND: Trends in overweight and obesity among expectant parents can provide useful information about the family environment in which children will grow up and about possible social inequalities that may be passed on to them. Therefore, we aimed to assess whether the prevalence of underweight, overweight and obesity changed over time in pre-pregnant women and their male partners in northern Sweden, and if there were any educational inequalities.
METHODS: This study is based on cross-sectional data from a repeated survey of the population in Västerbotten, Sweden. The study population included 18,568 pregnant women and 18,110 male partners during the period 2010-2019. Multinomial logistic regression models were fitted separately for pregnant women and male partners to assess whether the prevalence of age-adjusted underweight, normal weight, overweight and obesity had evolved between 2010 and 2019, and whether trends differed by educational level.
RESULTS: Among women, obesity prevalence increased from 9.4% in 2010 to 11.7% in 2019. Among men, it went from 8.9 to 12.8%. Educational inequalities were sustained across the study period. In 2019, the prevalence of obesity was 7.8 percentage points (pp) (CI = 4.4-11.3) higher among women with low compared to high education. The corresponding figure for men was 6.4 pp (CI = 3.3-9.6).
CONCLUSIONS: It is not obvious that the prevalence of obesity among parents-to-be will decrease under current dispositions. Public health policies and practice should therefore be strengthened.
To assess whether enteral nutrition fomulas based either on fat or glucose influence glucose homeostasis differently in critically ill medical patients. All patients are admitted to a tertiary ICU and require mechanical ventilation.

Resting energy expenditure is assessed at baseline in the fasting state by indirect calorimetry. Total energy demand is calculated and patients are randomized to receive fat-based or glucose-based nutrition which is administered continously for 7 days. Indirect calorimetry is repeated on days 3 and 7 under continous nutrition. During the study period, various parameters of glucose homeostasis are assessed. Daily, there will be at least 3 measurements of blood glucose, more if the treating physician deems it necessary. Daily average glucose, daily glucose variability, overall area under the curve for glucose are calculated. Furthermore, energy intake by nutrition, medications (i.e. propofol), and glucose infusion, as well as substrate intake, and insulin demand per 24hrs are determined daily. Adverse effects such as episodes of hyper- or hypoglycemia, cholestasis, hypertriglyceridemia, diarrhea, vomiting, and the amount of gastric residual volume are noted.
Allergic rhinitis (AR) is a major chronic respiratory disease with a prevalence approaching nearly 25% in the worldwide population.Allergic Rhinitis is a common and relatively undiagnosed public health problem and has been reported as being one of the ten most common causes for outpatient attendances to the general practitioner. Long term untreated allergic rhinitis may lead on to asthma. When exposed to allergens (pollen, house dust mite etc) in the atmosphere, the mast cells in the nose burst and an inflammatory response is triggered and patients experience sneezing, itching, blocked nose and running. These allergens may be used as provocation agents to recreate the disease symptoms to confirm the diagnosis of which allergens one is allergic to. However, there is a risk of allergic reactions in doing so. Adenosine monophosphate (AMP)achieves the same goal by stimulating the mast cells and causing them to burst without actually the risks of allergen provocation tests. Such tests are now commonplace in research and clinical medicine. Nasal steroids are considered to be the most potent medications for allergic rhinitis, particularly nasal blockage. Nasal antihistamines are also available but they act mainly to limit nasal running, itching and sneezing and have lesser effect on blockage. The other advantage is that they act very quickly while steroids take at least 72 hours to begin acting and weeks to achieve maximal benefit. Finally, they are free of significant short and long term side effects. Having said that nasal steroids are very safe and unlike inhaled or oral steroids have not been shown to cause systemic side effects in adults. Therefore, it is interesting to see if a combination of an antihistamine and nasal steroid would add their good qualities mentioned above and by the act of reducing the dose of steroid reduce their side effects. To do this we will use nasal AMP challenge as an outcome measure as we have done research studies for over a decade with. We will look at noninvasive nasal airflow parameters, nasal nitric oxide levels, and for safety we will look at the overnight urinary cortisol and creatinine ratio which is the most sensitive and noninvasive test of urine to quantify how much steroid has been absorbed in the blood stream.
<P>PROBLEM TO BE SOLVED: To provide an additional research tool for elucidating the molecular mechanism of bone modulation, for screening and development of a candidate new drug, and for treatment of bone developmental and bone loss disorders.  <P>SOLUTION: A reagent, a compound, a composition, and a method related to new interactions of the extracellular domain of LRP5, HBM (a variant of the LRP5), and/or LRP6 with Dkk, including Dkk-1 are provided. A specific nucleic acid, a polypeptide, an antibody, an assay method, a diagnostic method, and a treating method are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. The Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the reagent and the method for modulating lipid levels and/or bone mass are useful in treating and diagnosing abnormal lipid levels and bone mass disorders such as osteoporosis.  <P>COPYRIGHT: (C)2009,JPO&INPIT
PURPOSE: Cancer is an independent risk factor for the development of venous thromboembolism (VTE). However, patients with high-grade glioma (HGG) including glioblastoma (GBM) are at a particularly high risk of VTE with an incidence up to 20-30% per year. Patients are often placed on anticoagulation if they are found to have VTE. However, patients with primary brain tumors such as HGG are at increased risk for intracerebral hemorrhage (ICH) even without the administration of anticoagulation. The combination of risk factors for ICH with anticoagulation and HGG complicates decision-making. Currently it is not known which of the direct oral anticoagulants (DOACs) are safest for patients with HGG in terms of adverse bleeding-related outcomes such as ICH. Furthermore, a deeper understanding of the clinical and molecular determinants of bleeding-related adverse outcomes in HGG is not fully characterized.
METHODS: In this retrospective study, we identified and gathered data on 75 consecutive patients with pathology-confirmed HGG with hospital encounters at two academic medical center hospitals in Austin between July 1, 2017 and June 30, 2022. We compared clinical and treatment-related factors among cohorts who had received various forms of anticoagulation or no anticoagulation.
RESULTS: Patients who were on rivaroxaban (3/7 (43%)) had a statistically significant association with more bleeding-related adverse events compared to those on apixaban (0/12 (0%)) or enoxaparin (0/5 (0%), p = 0.022) even though the groups were similar in characteristics including total time on the respective anticoagulation. Patients on anticoagulation vs those never on anticoagulation did not differ in terms of their studied demographic and clinical characteristics. Intriguingly, logistic regression analysis revealed that patients Astrocytoma, isocitrate dehydrogenase (IDH) mutant, grade 4 had a significant association with more adverse bleeding-related events even when controlling for other relevant factors (Odds Ratio compared to reference GBM: 49.4, 95% CI: 2.8, 2084.7; p = 0.013).
CONCLUSION: In this study we found that the use of rivaroxaban was associated with more bleeding-related events compared to apixaban and enoxaparin in patients with high-grade glioma. In this study we also found that the diagnosis of astrocytoma, IDH mutant, grade 4 was associated with more bleeding events. However, this is based on a small study and there is a need for larger studies to further evaluate these results.
Participants received a 35-40-minute intervention on the Tablet PC and an in-person 10-15-minute booster session conducted by interventionists within a month after the intervention. Participants in this condition completed a baseline assessment as well as a follow-up assessment 3 months later.