anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A cosmetic composition comprising a goniochromatic colorant capable of creating a background coated with the goniochromatic colorant and reflective particles capable of creating a highlight point which is visible to the naked eye when the composition is coated onto a support and illuminated with a light source is provided. It creates a desirable volumizing effect when applied to the skin, lip, or a support such as the cuticle. CONSTITUTION: The cosmetic composition comprises: a physiologically acceptable medium; at least one goniochromatic colorant; and various reflective particles and has an average gloss of 30 or more. The goniochromatic colorant is selected from liquid crystal pigments and multi-layer interference structural materials to allow 30deg. or more at the minimum of the deviation of a color angle of the cosmetic composition Dh to be observed on a layer of the cosmetic composition, based on the deviation in a radiation angle of 45deg. and an observation angle of 0 to 80deg.
BACKGROUND: Although the risk of dental procedures as a cause of bacteremia has been recognized, evidence regarding the association between dental procedures and late periprosthetic joint infection (LPJI) is scarce. We sought to determine whether dental procedures are associated with an increased risk of LPJI.
METHODS: The study was conducted under a case-crossover design using a large claims database in Japan. We identified adult patients who had undergone dental procedures and were hospitalized for LPJI between April 2014 and September 2021. Exposure to dental procedures was assessed during a case period of 1-4 weeks, with two control periods of 9-12 weeks and 17-20 weeks, preceding LPJI hospital admission. Conditional logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of LPJI associated with dental procedures in the case period compared with the two control periods.
RESULTS: In total, 241 patients with LPJI were included in the case-crossover study. At least one dental procedure was performed in 46 patients (19.1%) in the hazard period and in 75 patients (31.1%) in the control periods. The OR for LPJI with dental procedures was 0.96 (95% CI, 0.61-1.53; p = 0.88). Findings were robust in several sensitivity analyses, including stratification by whether the dental procedure included antibiotic prophylaxis.
CONCLUSIONS: This study suggests that dental procedures are not associated with increased risk of LPJI, and will raise questions about the recommendation for antibiotic prophylaxis before dental procedures.
A method is disclosed for enhancing interactions between nonpolar substances and polar liquids, such as interactions between nonpolar polymers and aqueous systems, using amphipathic peptides, without the need for conventional surfactants. The nonpolar substance may either be pretreated to enhance its interactions with polar liquids, or the polar liquid (e.g., water) may be pretreated to enhance the interactions. It is possible to coat large surface areas on nonpolar substances uniformly with polar liquids. Nonpolar particles may be uniformly suspended in polar liquids, to an extent that has not been previously reported. The alteration of the nonpolar surface can be surprisingly durable. The treated surface may be rinsed, and the treated nonpolar surface will still retain its enhanced properties for interacting with polar liquids. By contrast, conventional surfactants are washed away when the water or other polar liquid is removed.
The invention relates to a method and a system for providing a representation of synchronicity of electrical activation of heart tissue. The method includes obtaining a three-dimensional model of electrical activation of the heart. The three-dimensional model includes a mesh with a plurality of nodes, each node having associated therewith a time delay between stimulation of the heart at a stimulation site and activation of the heart at that respective node. For each node a stimulus site is defined at the location of that node. For each node a modified three-dimensional model of electrical activation of the heart resulting from stimulation at that node is determined. For each node a measure for heart activation synchronicity for the heart based on stimulation at that node is determined A heart synchronicity map is determined representing a three-dimensional model of the heart, indicating at each node the respective measure for heart activation synchronicity.
Optical genome mapping (OGM) is an emerging next-generation cytogenomic tool that enables a comprehensive analysis of structural variants (SVs) in the genome. OGM, in its current iteration, is performed on the Saphyr system, which is developed and marketed by Bionano Genomics (San Diego, CA). OGM employs imaging of ultra-long DNA molecules (\>150 kbp) that are labeled at a unique 6 base-pair sequence motif (CTTAAG) that occurs throughout the genome. The images of the labeled DNA molecules are used to generate a de novo assembly that can be compared to a reference genome to identify all classes of SVs, such as deletions, duplications, balanced/ unbalanced genomic rearrangements (insertions, inversions, and translocations), and repeat array expansions/contractions). In addition, a separate coverage-based algorithm enables the detection of genome-wide copy number analysis (similar to CMA), and the absence of heterozygosity (AOH) analysis. In the same assay, a concurrent or stepwise data analysis pipeline allows for sizing pathogenic CGG repeat expansions (consistent with fragile X syndrome) as well as D4Z4 repeat contractions which are consistent with facioscapulohumeral muscular dystrophy type 1 (FSHD1). Recently, in several studies, OGM has demonstrated excellent concordance with standard-of-care testing. Importantly, the OGM workflow can provide results within three-five days.

The aim of this double-blinded, multi-site, retrospective, observational, Institutional Review Board (IRB)-approved study is to evaluate the concordance of structural variant detection by OGM compared to standard of care tests (such as CMA, karyotyping, Southern blot analysis, PCR, FISH, and/or NGS, etc.), in a large cohort containing a variety of SVs including aneuploidies, intragenic and contiguous deletions, duplications, balanced and unbalanced translocations, inversions, isochromosomes, ring chromosomes, repeat expansions, repeat contractions, and more. This study is also designed to assess the sensitivity, specificity, and reproducibility of OGM analysis conducted at multiple sites, by numerous operators, and on different Saphyr instruments. Consensus testing and interpretation protocols were developed and implemented at all sites.
The invention relates to a coated granular material, wherein the coating is a resin, comprising the reaction producing of at least one compound selected from the group consisting of cardol, cardanol or derivatives or oligomers of these compounds with an isocyanate component, and to a method for the preparation thereof. Water-soluble granular materials are suitable as substances to be coated. Examples of granular substances are fertilizers, crop protection agents, insecticides, pesticides, fungicides, drying agents and mixtures thereof. The substance coated according to the invention has advantageous properties since the resin can be applied in a selective and economical manner to the substrates due to its low tackiness. In particular, coated fertilizer granulates are advantageous in that, with regard to the applied amount of fertilizer, they can provide more nutrients to the plant. In addition, fertilizers can be provided that can provide nutrients to the plant over a longer period of time and continuously and they have an exact and reproducible release behavior according to the type of plant to be treated. Furthermore, the polyol component of the coating can be obtained from the renewable raw material cashew nut oil.
Gut microbes can influence numerous aspects of human biology. Alterations in the function and composition of gut microbial flora (gut microbiota) have been linked to different diseases such as obesity, diabetes and inflammation. Advanced Glycation End products (AGEs) are formed via the Maillard reaction, which consists of a complex network of non-enzymatic reactions involving the carbonyl groups of reducing sugars which react with the amino groups of proteins. AGEs are produced in vivo and being consumed. They have been implicated in increased risk of different diseases including atherosclerosis, CAD and kidney diseases. In this study, the investigators are evaluating the effects of consuming a low AGE diet in participants on peritoneal dialysis on the gut bacteria and inflammation.
Accommodative/vergence therapy (60 minutes per visit, one time per week, 12-14 weeks) and home reinforcement (15 minutes each time, five times per week, 12-14 weeks) will be provided to patients of treatment group. These therapy includes accommodative, vergence and anti-suppression technique. No drug is used during the whole therapy process.
An isolated  Bacillus  strain LSSAO1 is provided. When fed to a bird, this and other  Bacillus  strains described herein provide benefits to the birds. For example, administration of the one or more  Bacillus  strain can increase low G+C, gram positive bacteria in the gastrointestinal flora of the bird. These type of bacteria are increased by antibiotics and include beneficial  Clostridium . Administration of the one or more  Bacillus  strain can also inhibit pathogen in the bird, such as  E. coli, Salmonella , and  Clostridium . These benefits can enhance feed conversion in poultry. Useful combinations of  Bacillus  strains and methods of using one or more  Bacillus  strain are also provided.
The High-intensity interval training group was instructed to complete exercise sessions of 4x4-minutes intervals at 85-95% of maximal heart rate, 3 times a week for 8 weeks. This type of exercise include 10 minutes warm-up, followed by four intervals of four minutes high-intensity (85-95% of HRmax), with three minutes active breaks (70% of HRmax) between each interval, and ending with seven minutes cool-down. An exercise session last for 42 minutes, where the participants should breathe heavily and feel exhausted four times.
Cancer evolution is a multifaceted process leading to dysregulation of cellular expansion and differentiation through somatic mutations and epigenetic dysfunction. Clonal expansion and evolution is driven by cell-intrinsic and -extrinsic selective pressures, which can be captured with increasing resolution by single-cell and bulk DNA sequencing. Despite the extensive genomic alterations revealed in profiling studies, there remain limited experimental systems to model and perturb evolutionary processes. Here, we integrate multi-recombinase tools for reversible, sequential mutagenesis from premalignancy to leukemia. We demonstrate that inducible Flt3 mutations differentially cooperate with Dnmt3a, Idh2, and Npm1 mutant alleles, and that changing the order of mutations influences cellular and transcriptional landscapes. We next use a generalizable, reversible approach to demonstrate that mutation reversion results in rapid leukemic regression with distinct differentiation patterns depending upon co-occurring mutations. These studies provide a path to experimentally model sequential mutagenesis, investigate mechanisms of transformation and probe oncogenic dependency in disease evolution.
Vascular risk factors, including diabetes, hypertension, hyperlipidemia, and obesity, pose significant health threats with implications extending to neuropsychiatric disorders such as stroke and Alzheimer's disease. The Asian population, in particular, appears to be disproportionately affected due to unique genetic predispositions, as well as epigenetic factors such as dietary patterns and lifestyle habits. Existing management strategies often fall short of addressing these specific needs, leading to greater challenges in prevention and treatment. This review highlights a significant gap in our understanding of the impact of genetic screening in the early detection and tailored treatment of vascular risk factors among the Asian population. Apolipoprotein, a key player in cholesterol metabolism, is primarily associated with dyslipidemia, yet emerging evidence suggests its involvement in conditions such as diabetes, hypertension, and obesity. While genetic variants of vascular risk are ethnic-dependent, current evidence indicates that epigenetics also exhibits ethnic specificity. Understanding the interplay between Apolipoprotein and genetics, particularly within diverse ethnic backgrounds, has the potential to refine risk stratification and enhance precision in management. For Caucasian carrying the APOA5 rs662799 C variant, pharmacological interventions are recommended, as dietary interventions may not be sufficient. In contrast, for Asian populations with the same genetic variant, dietary modifications are initially advised. Should dyslipidemia persist, the consideration of pharmaceutical agents such as statins is recommended.
The invention relates to a nutritious juice liquor formula and a brewing technology. The nutritious juice liquor formula comprises Saussurea involucrate, Cornu Cervi Pantotrichum, Herba Sedi Aizoon, centipede notoginseng, Radix Notoginseng, Hibiscus trionum Linn and the like. The brewing technology includes the steps of preparing minor ingredients, boiling the minor ingredients in water with a soft fire, filtering out after placing the minor ingredients for three times with color change, placing dried human placenta powder into cooked glutinous rice at 30-40 DEG C, vatting, fermenting and the like. The brewing technology is characterized by preparing nutritious juice liquor from best-quality medicinal materials according to a traditional method. Original ecological pulp liquor prepared by cold fermentation according to the brewing technology is natural, green, free of additives and suitable for various people and can be drank daily in lifetime particularly for the middle-aged and aged people. The middle-aged and aged people with essential qi and immunity declining gradually are susceptible to multiple kinds of chronic wasting diseases, and the nutritious juice liquor is capable of strengthening the body resistance, tonifying deficiency, combining tonification with purgation, strengthening and curing the middle warmer and regulating and reinforcing asthenic diseases and deficiency of qi and blood in viscera to enable a human body to reach yin and yang in equilibrium and qi-blood smoothness.
PEEP was routinely set at 6 cm H2O. If it was in a state of Trendelenburg position or carbon dioxide pneumoperitoneum, PEEP was set to 8 cm H2O.
Peripheral congestion is caused by an excess of fluid in tissues and vessels. Fluid overload is associated with poor outcome in heart failure (HF)(1). Several clinical signs can suggest peripheral congestion, such as peripheral edema or neck vein distention. In particular, the clinical sign of the neck jugular vein distention is used to estimate right atrial pressure (RHC) and is associated with fluid overload and congestion. Nevertheless, clinical assessment is somewhat subjective depending on the anatomy of the patient's neck and on the expertise of the physician (2). It has been reported that the detection of elevated RAP can be measured using a bedside ultrasound (US)(3). In this study, the Authors compared the jugular vein distensibility (IVD) ratio assessed with US with the invasive measure of the RAP reporting a good accuracy in detecting normal RAP. They showed a good performance of this diagnostic test, nevertheless, they evaluated this diagnostic test in a mix population including only 27 patients with congestive HF. More recent studies showed the prognostic value of the IVD ratio in patients with HF (4). Nevertheless, a specific threshold of the internal JVD ratio to identify patients with normal RAP in the setting of patients with systolic chronic HF (CHF) has never been described. Furthermore, in patients with CHF clinical signs of congestion cannot always be evident at clinical examination, making the decision to modify diuretic dosage or to introduce vasodilator drugs uneasy. Thus, a convenient, accurate, and reproducible non-invasive tool to identify patients with normal RAP (normal mean RAP is 7 or less mmHg) patients with systolic CHF would be desirable to tailor therapy, in particular in outpatient clinics.

The main hypothesis of this study is that US-assessment of the internal JVD could be an accurate diagnostic tool to identify patients with normal RAP in this challenging set of patients.

The primary aim of the study prospectively validates an US-assessed internal JVD ratio to identify patients with systolic CHF and RAP of 7 or less mmHg measured by RHC. In a calibration cohort, a threshold of the JVD ratio above which the RAP is normal with the highest accuracy will be identified and then this diagnostic tool with a defined JVD ratio will be validated in a second prospective validation cohort.
1. Technical Result Increase in efficiency of treatment of pathological conditions mediated by TNF-alpha ferment.                  2. Essence Compound of the formula wherein R1-R6, X, Y and Z have the values indicated in the specification; said compound is useful in treating diseases conditions mediated by TNF-alpha, such as rheumatoid arthritis, osteoarthritis, sepsis, inflammation of central nervous system; methods for their production and pharmaceutical compositions containing the same.          3. Field of Application Medicine.                         Tables: 15
BACKGROUND: Arteriovenous (AV) access practice and its outcomes vary internationally. To provide a better understanding of the patterns and outcomes of AV access creation, we investigated the patency and risk factors of arteriovenous fistulas (AVFs) and grafts (AVGs) as initial AV access in the Korean adult population using data from the last 10 years.
METHODS: The National Health Insurance Service database was queried retrospectively to identify patients undergoing hemodialysis with AVFs and AVGs as well as their clinical characteristics and outcomes from 2008 to 2019. AV access patency and its associated risk factors were evaluated.
RESULTS: During the study period, 64,179 AVFs and 21,857 AVGs were placed. The mean patient age was 62.6 ± 13.6 years (21.5% were ⩾75 years old), and 39.3% patients were women. More than half of the patients underwent AV access creation at tertiary care hospitals. At 1 year, the primary, primary assisted, and secondary patency rates were 62.2%, 80.7%, and 94.2% for AVFs, and 46.0%, 68.4%, and 86.8% for AVGs, respectively. AVG, older age, female sex, diabetes, and creation at general hospitals (vs tertiary hospitals) were associated with decreased patency outcomes (all, p < 0.05).
CONCLUSION: This study using national data showed that three quarters of patients with AV access had AVF and AVF showed superior performance to AVG and identified several patient and center factors related to AV access patency in Korea.
PURPOSE:To provide a soft drug for oral application, having excellent feeling and retainability in the oral cavity, and improved slow-releasing property and improved transmucous absorptivity and bioavailability of the drug component, by using a water-soluble protein, a polyhydric alcohol and a fatty acid ester as the base components. CONSTITUTION:The objective drug contains (A) a drug to be absorbed through the oral mucosa, (B) a water-soluble protein to promote the absorption of the drug (preferably animal protein, especially gelatin or solubilized collagen), (C) a polyhydric alcohol to control and maintain the softness of the drug and modify the rate of dissolution or disintegration (e.g. glycol, triol, etc.) and (D) a fatty acid ester, preferably the ester of a 8-20C fatty acid and a C1-20 alcohol and/or a carboxyvinyl polymer. The amount of the component A is 0.05-60wt% based on the whole drug preparation, that of the component B is 1-100pts. per 1pt. of the component A, and those of the components C and D are 0.03-2pts. and 0.03-7pts. per 1pt. of the component B, respectively.
PURPOSE: Pain is a common symptom following proximal femoral fractures (PFF), however, information on its treatment in terms of agents and type of use (scheduled vs. pro re nata [PRN]) is scarce. The main objective of this study was to examine pain medication regimens according to pain intensity following PFF. Furthermore, we explored the utilization of medication plans.
METHODS: The "ProFem"-study on healthcare provision, functional ability, and quality of life after PFF is a German population-based prospective cohort study based on statutory health insurance data and individually linked survey data from different time points including information on the currently used medication. This present analysis refers to the participants' baseline interviews (about 3 months following PFF) conducted from 2018 to 2019 in the participants' private surroundings.
RESULTS: The study population comprised 444 participants (mean age: 81.2 years, 71.0% female). Half of them reported high intensity pain, and the mean value for the EuroQol visual analogue scale was 50.8. Most commonly used analgesics were metamizole and tilidine/naloxone. Among participants with high intensity pain, 21.9% received only PRN pain medication and 17.2% no pain medication at all. Overall, 61.5% of participants presented any (printed) medication plan and only 25.2% a "federal standardized medication plan" (BMP).
CONCLUSION: As a substantial number of patients reports high intensity pain about 3 months following a PFF, the large proportion of those receiving no or only PRN pain medication raises questions regarding the appropriateness of the therapy. The overall low utilization of the BMP indicates potential for improvement.
The invention relates to a medical monitoring system controller (10) for controlling a medical monitoring system (1). The controller is configured to control the medical monitoring system such that the time resolution of storing measured medical parameters like blood pressure, heart rate, etc. in the storage unit (8) depends on an identification of the user like a physician or nurse, wherein the identification is preferably an authentication of the user. In particular, if the user has been identified, the time resolution of storing the measured medical parameters can be increased. It is not necessary to store the medical parameters at all times with a relatively high temporal resolution, but this temporal resolution can generally be relatively low and increased if a user has been identified. This allows a significant reduction in the required storage capacity.
PURPOSE:To obtain a bathing agent, containing a phthalide derivative as an active ingredient and capable of promoting blood circulation and enhancing warm bath effects without any problems in clouding of bath water, etc. CONSTITUTION:The objective substance is obtained by using a phthalide derivative expressed by the formula (R1 is H, OH, methoxy, amino, dimethylamino, etc.; R2 is H, OH, methoxy, etc.; R3 is H or methoxy; R4 is H, amino, dimethylamino or nitro; R5 is H, alkyl or alkoxyl, except when all the R1 to R4 are H) alone or two or more thereof in combination, further suitably blending inorganic salts, enzymes, emollient agents, humectants, perfumes, coloring matters, etc., used as a bathing agent therewith and preparing the bathing agent according to a conventional method. The aforementioned agent can be prepared in a dosage form such as a liquid, a powder, a granule, a crystal or a tablet. The compound expressed by the formula is added in an amount so as to afford 0.03-60ppm in the bath water.