anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Out of hospital cardiac arrest is a major health problem accounting for 375000 deaths each year in Europe. Even after return to spontaneous circulation, survival is poor because of complications such as post-anoxic encephalopathy and multi-organ failure. The pathophysiology of cardiac arrest implies ischemia-reperfusion and sepsis like syndrome. These conditions are frequently associated with microvascular dysfunction that can be the "motor" of multi-organ failure. Few means allow the exploration of microvascular function in human. Recently, StO2, a non-invasive technique assessing microvascular function has been described. This technique measures the tissular saturation of a muscle using the near-infrared spectroscopy technique. It has been described to be a good prognostic factor during haemorrhagic shock state. Dynamic parameters such as reperfusion slope allow discriminating between survivors and survivors after severe sepsis. This dynamic test assesses the microvasculature recruitment that could be a marker of better prognosis. The aim of this study is to evaluate muscle StO2 as a prognostic factor after out of hospital cardiac arrest.
A machine learning system and method utilizing artificial intelligence that improves the provisioning of healthcare and reduces the total cost of healthcare and lost productivity. The approach creates a quantifiable assessment of quality and a ranking number measuring a provider's quality of healthcare services. The machine learning system makes a determination of quality based on a clinical evaluation database, an employee related time and attendance database, and a costing database. The system analyzes how quickly a provider returns an employee to work at or near pre-absence productivity and at what cost. The system creates a ranking number that provides employees with a comparison of providers. Employees may then be incentivized to seek high value providers.
BACKGROUND: Apnea is common in preterm infants and can be accompanied with severe hypoxic damage. Early assessment of apnea risk can impact the prognosis of preterm infants. We constructed a prediction model to assess apnea risk in premature infants for identifying high-risk groups.
METHODS: A total of 162 and 324 preterm infants with and without apnea who were admitted to the neonatal intensive care unit of Xiamen University between January 2018 and December 2021 were selected as the case and control groups, respectively. Demographic characteristics, laboratory indicators, complications of the patients, pregnancy-related factors, and perinatal risk factors of the mother were collected retrospectively. The participants were randomly divided into modeling (n = 388) and validation (n = 98) sets in an 8:2 ratio. Least Absolute Shrinkage and Selection Operator (LASSO) and multivariate logistic regression analyses were used to independently filter variables from the modeling set and build a model. A nomogram was used to visualize models. The calibration and clinical utility of the model was evaluated using consistency index, receiver operating characteristic (ROC) curve, calibration curve, and decision curve, and the model was verified using the validation set.
RESULTS: Results of LASSO combined with multivariate logistic regression analysis showed that gestational age at birth, birth length, Apgar score, and neonatal respiratory distress syndrome were predictors of apnea development in preterm infants. The model was presented as a nomogram and the Hosmer-Lemeshow goodness of fit test showed a good model fit (χ2=5.192, df=8, P=0.737), with Nagelkerke R2 of 0.410 and C-index of 0.831. The area under the ROC curve and 95% CI were 0.831 (0.787-0.874) and 0.829 (0.722-0.935), respectively. Delong's test comparing the AUC of the two data sets showed no significant difference (P=0.976). The calibration curve showed good agreement between the predicted and actual observations. The decision curve results showed that the threshold probability range of the model was 0.07-1.00, the net benefit was high, and the constructed clinical prediction model had clinical utility.
CONCLUSIONS: Our risk prediction model based on gestational age, birth length, Apgar score 10 min post-birth, and neonatal respiratory distress syndrome was validated in many aspects and had good predictive efficacy and clinical utility.
Brain microvascular endothelial cells (BMECs), an important component of the neurovascular unit, can promote angiogenesis and synaptic formation in ischaemic mice after brain parenchyma transplantation. Since the therapeutic efficacy of cell-based therapies depends on the extent of transplanted cell residence in the target tissue and cell migration ability, the delivery route has become a hot research topic. In this study, we investigated the effects of carotid artery transplantation of BMECs on neuronal injury, neurorepair, and neurological dysfunction in rats after cerebral ischaemic attack. Purified passage 1 endothelial cells (P1-BMECs) were prepared from mouse brain tissue. Adult rats were subjected to transient middle cerebral artery occlusion (MCAO) for 30 min. Then, the rats were treated with 5 × 105 P1-BMECs through carotid artery infusion or tail vein injection. We observed that carotid artery transplantation of BMECs produced more potent neuroprotective effects than caudal injection in MCAO rats, including reducing infarct size and alleviating neurological deficits in behavioural tests. Carotid artery-transplanted BMECs displayed a wider distribution in the ischaemic rat brain. Immunostaining for endothelial progenitor cells and the mature endothelial cell markers CD34 and RECA-1 showed that carotid artery transplantation of BMECs significantly increased angiogenesis. Carotid artery transplantation of BMECs significantly increased the number of surviving neurons, decreased the cerebral infarction volume, and alleviated neurological deficits. In addition, we found that carotid artery transplantation of BMECs significantly enhanced ischaemia-induced hippocampal neurogenesis, as measured by doublecortin (DCX) and Ki67 double staining within 2 weeks after ischaemic injury. We conclude that carotid artery transplantation of BMECs can promote cerebral angiogenesis, neurogenesis, and neurological function recovery in adult rats after ischaemic stroke. Our results suggest that carotid injection of BMECs may be a promising new approach for treating acute brain injuries.
<P>PROBLEM TO BE SOLVED: To paste medical images as well as information on nodes in the image on an interpretation report.  <P>SOLUTION: When target image key information, positional information of the node in the target image, and information on an operation type for instructing to "paste an image on a report" are supplied to an image management part 2b from an input management part 2a, the image management part reads out the target image from an image storing part 2c and generates an image for pasting by duplicating it. The image management part 2b supplies the positional information of the nodes in the target image to an image analyzing part 2e to have the dimensions or the like of the node analyzed and receives node information being a result of the analysis. The image management part 2b supplies the generated image for pasting and the node information received from the image analyzing part 2e to an output management part 2f. The output management part 2f pastes the image for pasting and the node information supplied from the image management part 2b on a prescribed position on a screen for creating the interpretation report which is displayed on a monitor 3.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Certolizumab pegol (CZP; CIMZIA™) is the only Fc-free tumor necrosis factor inhibitor with data from a clinical study demonstrating no to minimal placental transfer. The pharmacokinetics (PK) of certolizumab pegol during pregnancy and postpartum in women with chronic inflammatory diseases were assessed using a population PK model based on data from the CHERISH study (NCT04163016), a longitudinal, prospective, open-label PK phase IB study. Model development was performed in NONMEM using a frequentist prior approach, with prior information based on a population PK model for certolizumab pegol in non-pregnant adult patients (NCT04740814). A one-compartment model with first-order absorption (Ka = 0.236 1/day) and linear elimination (CL/F = 0.416 L/day) from the central compartment (V/F = 7.86 L) best described certolizumab pegol PK in the CHERISH study. The structural model parameters were estimated with good precision (RSE < 25%). Baseline BW was included as a covariate on CL/F and V/F. Pregnancy trimester and time-varying log-transformed anti-drug antibody (ADA) titer were identified as the only significant covariates for CL/F with a comparable influence on CL/F. Individuals with higher ADA titer (75th percentile) during pregnancy exhibited CL/F up to 1.43-fold higher relative to individuals postpartum that showed median levels of ADA titer. However, the confidence interval for the combined effect of pregnancy stage and ADA titer effects on CL/F overlapped with the CL/F range of the typical individual postpartum. In addition, simulations showed a large overlap in certolizumab pegol concentrations between pregnant and non-pregnant adults. The findings of this population PK analysis support the maintenance of established certolizumab pegol dosing regimens throughout pregnancy.
The present invention relates to nanometer traditional Chinese medicine for preventing and curing osteoporosis, which belongs to the field of biologic medicine preparation. The nanometer traditional Chinese medicine for preventing and curing osteoporosis is prepared from oyster shell, activity hairy antler, old arable soil, kudzuvine root, eucommia bark, ginseng and tortoiseshell. The present invention has the preparation technologies that oyster calcium and the activity hairy antler, namely the hairy antler processed with a freeze drying method, are prepared by applying a nanometer technology; ginseng powder is taken for being ground into fine powder, the eucommia bark is extracted by alcohol, a tortoiseshell water decocting solution, an old arable soil water decocting solution and a kudzuvine root water decocting solution are combined, vaporized through pressure reduction and concentrated into paste. The paste is mixed with eucommia bark paste, the ginseng fine powder and activity hairy antler powder, and the paste, the eucommia bark paste, the ginseng fine powder and the activity hairy antler powder are dried under reduced pressure for being prepared into micro powder. Then, the nanometer oyster calcium and the traditional Chinese medicine micro powder are completely mixed by a high speed agitator for being prepared into a finished product. The present invention has the advantages of scientific and novel design, original preparation technology and generally medicine material source, and creates the organic synergy of cure methods of benefiting qi, replenishing energy, strengthening the kidneys, replenishing the marrow, supplying calcium, strengthening the bones and a preparation with the functions of supplying calcium and replenishing the kidneys. The present invention integrally enhances organism functional activities, and adjusts endocrine dyscrasia. The present invention adjusts metabolic calcium disorder from bone remodeling aspects, and has a remarkable.
The invention discloses a traditional Chinese medicine composition used for treating dysmenorrheal. The medicine composition is characterized in that the medicine composition is prepared from the raw materials of, by weight: 5-8 parts of salvia miltiorrhiza, 5-8 parts of vinegar-fried yanhusuo tuber, 5-8 parts of doubleteeth angelica root, 5-8 parts of safflower, 5-8 parts of argy wormwood leaf, 10-15 parts of trogopterus dung, 10-15 parts of ligusticum, 10-15 parts of achyranthes bidentata, 10-15 parts of prepared nutgrass galingale rhizome, 10-15 parts of motherwort, 5-8 parts of vinegar-fried Himalayan teasel root, 5-8 parts of dried ginger, 8-10 parts of Mongolian milkvetch root, 8-10 parts of prepared rhizome of rehmannia, 8-10 parts of cinnamomum cassia, and 8-10 parts of lightyellow sophora root. According to the invention, pure traditional Chinese medicines and a reasonable formula are adopted. The prepared traditional Chinese medicine composition has the functions of meridians warming, coronary circulation promoting, cold eliminating, pain relieving, blood circulation activating, stasis removing, and the like. The medicine composition especially has good effect against exuberance yin coldness caused by uterus coldness and affections of exogenous wind-cold. The medicine composition assists in removing internal coldness, warming uterus, and enhancing uterus vigor.
<P>PROBLEM TO BE SOLVED: To provide a highly effective and safe atopic dermatitis-improving agent, and to provide foods for animals and human, containing the atopic dermatitis-improving agent.  <P>SOLUTION: The atopic dermatitis-improving agent has high effects and immediate effects by combinedly using acid xylo-oligosacharide having uronic acid group and extracts of Lyophyllum decastes Sing. The acid xylo-oligosaccharide is a mixture composition of oligosaccharides comprising xylose oligomers having different polymerization degree, and the average polymerization degree of the xylose oligomers is preferably 5.0-15.0. The uronic acid is preferably glucuronic acid or 4-O-methyl-glucuronic acid. The functional foods or foods for animals, and the functional foods or foods for human, comprising the atopic dermatitis-improving agent, are provided.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Chronic poor health and impaired work ability entails both personal suffering and considerable social costs. Poverty, homelessness, difficulties to handle complex issues, and maltreatment may affect health outcomes in the long run. Both sense of coherence (SOC) and the ability to understand health-related information (health literacy) influences personal coping strategies and thus the motivation to participate in health care and rehabilitation, which is known to have a positive impact on health outcome. The purpose of this study is to evaluate whether an intervention with patient education in study circles, aiming to empower patients to participate in health care and rehabilitation by increasing health literacy and sense of coherence, may have a causal effect on perceived health, ability and function as well as independence and quality of life for patients with long-term health-related disabilities and passive coping strategies. The study design is a cluster randomized controlled study comparing the intervention in addition to treatment as usual (TAU) with TAU. Follow-up is performed with validated questionnaires after 3, 6 and 12 months. Primary outcome is net inactivity days (net days without employment or rehabilitation) and secondary outcome variables are the number of net and gross days with sick leave during the follow-up period, sense of coherence, health literacy, health-related quality of life, confidence in own problem solving ability, work ability and work satisfaction, social function and health habits, symptoms of depression, anxiety, and exhaustion as well as pain and catastrophization. Randomization will be performed at Primary Care Center (PCC) level. Around 30 Primary Care Centers and 400 patients will be included in the study. The intervention consists of patient education with study circles meeting half a day per week for eight following weeks. The study is expected to show whether patient education in study circles aiming to increase health literacy and sense of coherence has a causal effect on perceived health, ability and function, independence and quality of life for patients with long-term health-related disabilities and passive coping strategies compared to TAU.

The research subjects will answer all questionnaires in a web based tool approved for storing research data, esMaker (Entergate AB) on their mobile phone, iPad or computer. Individual web links to the questionnaires will be distributed via e-mail. Research subject identity is replaced with individual codes in esMaker. The research assistant will be in charge of the CodeKey and responsible for distributing the web links and for reminding the research subjects to fill in the questionnaires.
Patients receive bryostatin 1 IV continuously over 72 hours immediately followed by cisplatin IV over 1 hour. Treatment continues every 3 weeks for a minimum of 2 courses in the absence of disease progression.
The invention relates to an ibuprofen sustained-release preparation and a preparation method thereof. The ibuprofen sustained-release preparation is characterized by comprising a main medicament of ibuprofen, blank pellets, a lubricant, an adhesive and a diluent, and is mainly prepared by adding medicament on lamination. The invention belongs to the technical field of pharmaceutical preparations and aims at providing the ibuprofen sustained-release preparation with good patient compliance, small side effects, lasting efficacy and stable curative effect. The ibuprofen sustained-release preparation can realize smooth and slow medicament release, avoid the peak valley phenomenon which is easy to occur during the medicament release of ordinary preparations, enable the efficacy to be more lasting, exist in the blood for 12-24 hours stably, be widely distributed in a whole body, be high in bioavailability, be convenient to take, be few in administration times, be low in toxicity and side effects, be stable in efficacy and improve the safety of a medicament. The invention also aims at providing the preparation method of the ibuprofen sustained-release preparation, which is simple in preparation process, good in repeatability, high in production efficiency and applicable to industrialized mass production. Medicament-carrying micro-pellets prepared by the method are smooth, round and even, and are uniform in release and good in stability.
Cold exposure activates brown adipose tissue (BAT) and potentially improves cardiometabolic health through the secretion of signaling lipids by BAT. Here, we show that 2 h of cold exposure in young adults increases the levels of omega-6 and omega-3 oxylipins, the endocannabinoids (eCBs) anandamide and docosahexaenoylethanolamine, and lysophospholipids containing polyunsaturated fatty acids. Contrarily, it decreases the levels of the eCBs 1-LG and 2-LG and 1-OG and 2-OG, lysophosphatidic acids, and lysophosphatidylethanolamines. Participants overweight or obese show smaller increases in omega-6 and omega-3 oxylipins levels compared to normal weight. We observe that only a small proportion (∼4% on average) of the cold-induced changes in the plasma signaling lipids are slightly correlated with BAT volume. However, cold-induced changes in omega-6 and omega-3 oxylipins are negatively correlated with adiposity, glucose homeostasis, lipid profile, and liver parameters. Lastly, a 24-week exercise-based randomized controlled trial does not modify plasma signaling lipid response to cold exposure.
Group II (treatment with Inoue et al.'s technique) Fifteen patients (15 wrists) were evaluated at an average of 51 months. Nine patients were men and 6 were women. The mean age of the group at the time of surgery was 37.5 years (range, 24 to 58 years). The dominant hand was involved in 10 and nondominant hand, in seven.
After baseline measures are taken, 10 overweight (BMI 25-30 kg/m2) young adult participants (ages 20-40 years) without major chronic conditions including diabetes, kidney, cardiac, or liver disease will receive an isocaloric, high protein and low carbohydrate ketogenic diet for 2 weeks. Each participant will consume one meal daily in the Diet and Nutrition (DAN) laboratory metabolic kitchen at the University of Virginia (UVA) and receive the remainder of the daily food allocation packed out to consume at home. Plate-waste method and NDS-R software will be used to measure food consumption (all served and packed-out foods and all uneaten and returned portions will be weighed). Weight, blood pressure and symptom surveys will be monitored at least 3 times a week. Fasting blood and 24 hour urine samples will performed at baseline and the end of each week. Stool for microbiota will be assess at baseline and end of study. Adherence will be confirmed with urinary biomarkers (e.g. urinary nitrogen) and point of care blood testing ketones. Differences in estimated glomerular filtration rate (GFR) determined from serum creatinine and cystatin C will be evaluated for each participant to assess magnitude of increase in GFR on the ketogenic diet. Over the past decade new panels of biomarkers have become available measuring glomerular permeability (urine albumin to creatinine ratio; UACR) and kidney injury and repair (IL-18, kidney injury molecule 1 \[KIM-1\], neutrophil gelatinase-associated lipocalin \[NGAL\], liver fatty acid type binding protein \[L-FABP\], tumor necrosis factor α \[TNF-α, TNF receptor 1 and 2\], transforming growth factor beta \[TGF-β\], human cartilage glycoprotein 39 \[YKL-40\], and monocyte chemoattractant protein 1 \[MCP-1\]). Change in UACR comparing the end of two weeks to baseline will be the primary outcome. Changes in other kidney injury markers will be assessed as secondary and exploratory outcomes. Additional exploratory outcomes will include urine metabolomics and stool 16S rRNA to characterize the gastrointestinal microbiota. Biosamples will be stored in a repository for future uses.
AIM: Dietary therapy of glycogen storage disease I (GSD I) is based on frequent feeding, with a high intake of complex carbohydrates (supplied by uncooked cornstarch), restriction of sugars, and a lower amount of lipids. There is limited information about the dietary regimen in patients with GSD, which might affect the intestinal luminal pH and microbiota composition. The aim of this study to investigate the intestinal microbiota composition in patients with GSD receiving diet treatment.
METHOD: Twelve patients who were followed up with GSD I after the diagnosis receiving diet therapy and 11 healthy children have been enrolled. Intestinal microbiota composition was evaluated by 16 s rRNA gene sequencing.
RESULTS: A significant difference was found for beta-diversity between the GSD group and controls. A significantly lower abundance of Firmicutes and higher abundance of Actinobacteria was found in GSD group compared to the controls. Akkermansia, Pseudoalteromonas, Uruburella, and Castellaniella were dominant in the GSD patients at the genus level, while Faecalibacterium, Bacterioides, Gemmiger, Parabacteroides in the control group. At species level, Faecalibacterium prausnitzii decreased, and Akkermansia muciniphila were dominant in children with GSD.
DISCUSSION: There is a substantial change in the composition of the gut microbiota, reduction of F. prausnitzii and an increase of A. muciniphila in children with GSD receiving consumption of uncooked cornstarch. Alterations of the intestinal microbiota might be related with the disease itself or dietary restrictions in patients with GSD, however, in certain condition, dysbiosis can negatively affect the course and make it difficult to control the disease.