anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Plant diseases significantly impact food security and food safety. It was estimated that food production needs to increase by 50% to feed the projected 9.3 billion people by 2050. Yet, plant pathogens and pests are documented to cause up to 40% yield losses in major crops, including maize, rice, and wheat, resulting in annual worldwide economic losses of approximately US$220 billion. Yield losses due to plant diseases and pests are estimated to be 21.5% (10.1 to 28.1%) in wheat, 30.3% (24.6 to 40.9%) in rice, and 22.6% (19.5 to 41.4%) in maize. In March 2023, The American Phytopathological Society (APS) conducted a survey to identify and rank key challenges in plant pathology in the next decade. Phytopathology subsequently invited papers that address those key challenges in plant pathology, and these were published as a special issue. The key challenges identified include climate change effect on the disease triangle and outbreaks, plant disease resistance mechanisms and its applications, and specific diseases including those caused by Candidatus Liberibacter spp. and Xylella fastidiosa. Additionally, disease detection, natural and man-made disasters, and plant disease control strategies were explored in issue articles. Finally, aspects of open access and how to publish articles to maximize the Findability, Accessibility, Interoperability, and Reuse of digital assets in plant pathology were described. Only by identifying the challenges and tracking progress in developing solutions for them will we be able to resolve the issues in plant pathology and ultimately ensure plant health, food security, and food safety.
A composition for the treatment of psoriasis vulgaris, and a method for its preparation are described. The compound is made from the following ingredients: 6 alpha ,9 alpha -difluoro-11 beta , 17 alpha -dihidroxy-16 alpha -methyl-21 trimethyl-acetoxy-1,4-pregnadiene-3,20 dione; (+)-17,21-dipropionyloxy-16 beta -methyl-9 alpha -fluoro-prednisolone; salicylic acid; tetracycline chloride; gentamycin sulfate; neomycin sulfate; trypsin; chymotrypsin; and bismuth. A method for the preparations of this composition is also disclosed. In this method, 6 alpha ,9 alpha -difluoro-11 beta ,17 alpha -dihidroxy-16 alpha -methyl-21-trimethyl-acetoxy-1,4-pregnadiene-3,20 dione and (+)-17,21-dipropionyloxy-16 beta -methyl-9 alpha -fluoroprednisolone are first mixed together under intensive agitation. Salicyclic acid, tetracycline chloride, gentamycin sulfate and neomycin sulfate are then added. Next, trypsin, chymotrypsin and bismuth are added. Finally, the preparation is mixed into a neutral cream, ointment, etc., at which time it is ready for use. This unique composition of ingredients acting together achieves excellant results in the treatment psoriasis vulgaris.
BACKGROUND: Despite increasing attention, disparities in outcomes for Black and Hispanic patients undergoing orthopedic surgery are widening. In other racial-ethnic minority groups, outcomes often go unreported. We sought to quantify disparities in surgical outcomes among Asian, American Indian or Alaskan Native, and Native Hawaiian or Pacific Islander patients across multiple orthopedic subspecialties.
MATERIALS AND METHODS: The National Surgical Quality Improvement Program was queried to identify all surgical procedures performed by an orthopedic surgeon from 2014 to 2020. Multivariable logistic regression models were used to investigate the impact of race and ethnicity on 30-day medical complications, readmission, reoperation, and mortality, while adjusting for orthopedic subspecialty and patient characteristics.
RESULTS: Across 1,512,480 orthopedic procedures, all patients who were not White were less likely to have arthroplasty-related procedures (P<.001), and Hispanic, Asian, and American Indian or Alaskan Native patients were more likely to have trauma-related procedures (P<.001). American Indian or Alaskan Native (adjusted odds ratio [AOR], 1.005; 95% CI, 1.001-1.009; P=.011) and Native Hawaiian or Pacific Islander (AOR, 1.009; 95% CI, 1.005-1.014; P<.001) patients had higher odds of major medical complications compared with White patients. American Indian or Alaskan Native patients had higher risk of reoperation (AOR, 1.005; 95% CI, 1.002-1.008; P=.002) and Native Hawaiian or Pacific Islander patients had higher odds of mortality (AOR, 1.003; 95% CI, 1.000-1.005; P=.019) compared with White patients.
CONCLUSION: Disparities regarding surgical outcome and utilization rates persist across orthopedic surgery. American Indian or Alaskan Native and Native Hawaiian or Pacific Islander patients, who are under-represented in research, have lower rates of arthroplasty but higher odds of medical complication, reoperation, and mortality. This study highlights the importance of including these patients in orthopedic research to affect policy-related discussions. [Orthopedics. 2024;47(3):e131-e138.].
The invention aims to provide polypeptide with immunomodulatory effects, namely undecapeptide which has immunomodulatory effects and is separated from bursa of Fabricius. The amino acid sequence of the polypeptide is SEQ ID NO:1. The bursa of Fabricius undecapeptide separated from a bursa of Fabricius extract product has a simple structure, has no toxic or side effect, and has poor immunogenicity. The polypeptide can be obtained by separation and extraction from bursa of Fabricius and also can be obtained by chemical synthesis. The polypeptide has low cost and can be put into mass production. The polypeptide has an induction effect on antibody production, and also can regulate production of cytokines and proliferation of lymphocyte and promote cellular immune response. In addition, the polypeptide also regulates differentiation of B cell in a dose-dependent mode. The polypeptide has a wide application prospect, taking an application of the polypeptide in the aspects of immunomodulation, treatment and the like for example.
FIELD: food industry. SUBSTANCE: carnallite produced on potassium mine is ground and subjected to chemical analysis for macroelements and trace elements, after which it is added to fresh water in amounts no greater than 1-1.5 teaspoon per 1 l fresh water. If necessary, after settling and removal of precipitate, water is saturated with carbon dioxide. Water is effective in treatment of nervous system, improvement of digestion, activation of liver function, amelioration of metabolic processes, and prevention of various pathologic conditions. EFFECT: simplified preparation procedure. 2 cl
PROBLEM TO BE SOLVED: To prepare a makeup cosmetic, good in oiliness feeling and extension and spread when coated and excellent in even usability by including an organosilicone resin as a binder for a powder. SOLUTION: This makeup cosmetic comprises a powder and an organosilicone resin as a binder for the powder in an amount of 0.1-8wt.% based on the powder. The content of the powder is 85-99.9wt.% based on the total amount of the cosmetic and talc, mica, titanium oxide, etc., are used. A part or all of the powder is preferably a silicone-treated powder obtained by treatment thereof with a linear organopolysiloxane. The cosmetic can be prepared as a makeup cosmetic such as an eye shadow, a rouge, an eyeliner, an eyebrow, a lipstick, a foundation or a concealer. The cosmetic has an unconventional new feeling of use and is excellent in usability such as easy dimming without causing uneven sticking.
BACKGROUND: Surgical treatment for Freiberg disease (also known as avascular necrosis of the metatarsal head) has not been completely defined. This retrospective study evaluated short-term outcomes after arthroscopic treatment of Freiberg disease.
METHODS: From 2015 to 2019, 13 patients (15 feet) diagnosed as having Freiberg disease were enrolled for arthroscopic surgery. Feet were divided based on the Smillie classification system (two with stage I, eight with stage II, three with stage III, one with stage IV, and one with stage V). Arthroscopic interventions, including synovectomy, debridement, chondroplasty, microfracture, and loose body removal, were performed without considering the Smillie classification stage. Radiologic outcomes were evaluated by radiography (preoperatively and 3, 6, and 12 months postoperatively) and magnetic resonance imaging (preoperatively and 12 months postoperatively). Clinical outcomes were evaluated using the American Orthopaedic Foot and Ankle Society (AOFAS) lesser metatarsophalangeal (MTP)-interphalangeal score and the visual analog scale (VAS) score. The MTP joint range of motion was measured using a goniometer preoperatively and postoperatively.
RESULTS: Radiologic studies showed no evidence of osteonecrosis progression in postoperative 12-month radiographs of any patients. Postoperative 12-month magnetic resonance images showed reduction of bone marrow edema, irregularity of subchondral bone, and cartilage defects in all patients. Significant improvements in AOFAS and VAS scores occurred at all postoperative time points compared with preoperative scores (P = .001). The MTP joint range of motion also showed improvement at last follow-up (P = .001).
CONCLUSIONS: Arthroscopic surgery for Freiberg disease showed excellent clinical outcomes, MTP joint range of motion, and short-term outcomes regardless of stage (Smillie classification) in radiologic evaluation.
The present invention refers to a novel method for obtaining a concentrated suspension of natural alcohol-free vanilla extract that maximizes extraction and minimizes the amount of ethanol required. The said process consists of solid-liquid extraction of vanilla cured in three or four counter-current stages with ethanol-water (60%) as a solvent. The extraction results in an extract of the highest concentration allowed by solubility (about eight grams solids/dm3) with an extraction yield higher than 90%. The extract obtained is evaporated at 50-101.3 kPa to a solids concentration around 36% by weight, which ensures the reduction of trace alcohol concentration. The energy required for evaporation is 0.44 kW-h/kg of extract. The evaporated solvent (with an average composition of 65% alcohol) is recycled to the solvent of the extraction process. The reconstituted vanilla extract concentrate has the same amount of vanillin and the main volatile compounds as the non-evaporated extract.
PURPOSE:To obtain a stable hair dye capable of readily dyeing the hair to the objective color tone or density by a user without adversely affecting the hair or skin. CONSTITUTION:The objective hair dye comprises an aglycone obtained by enzymically treating a ylidoid glycoside, e.g. genipin which is an aglycone of a geniposide and one or two or more amino acids, preferably selected from alanine, glycine, valine, aspartic acid, glutamic acid, arginine and lysine. The genipin is capable of dyeing the hair to various colors by changing the pH as follows: yellowish brown at pH 3.0, bluish brown at pH 5.0, blackish brown at pH 7.0 and brown at pH 8.0. The color tone can be changed by the kind of blended amino acids, e.g. the hair can be dyed to bluish black by blending the L-arginine, yellowish green by blending the L-glutamic acid and blue by blending the glycine at pH 3.5.
A preliminary study in the participating center showed a trend to lower ovarian response to stimulation and live birth rates after bariatric surgery compared to weight-matched patients. However, statistical significance was not reached, as the sample size was small.

The aim of the research project is to study the ovarian response and live birth rates of this bariatric surgery population, with a sufficient number of patients, in order to reach higher statistical power. This case-control study will involve 3 IVF (in-vitro fertilization) centers in France . All patients undergoing IVF with a history of bariatric surgery will be included from January 2012. Each case will be matched for BMI and age to the 2 next patients without bariatric surgery history and undergoing IVF and to one non-operated severely obese woman. Surgery procedures include sleeve gastrectomies and by-passes. The IVF results and live birth rates will be compared between the three groups.
Dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Approximately 10% of adult patients in clinical studies have had rate increases of 30 beats/minute or more, and about 7.5% have had a 50 mm Hg or greater increase in systolic pressure. Usually, reduction of dosage promptly reverses these effects. Because dobutamine facilitates atrioventricular conduction, patients with atrial fibrillation are at risk of developing rapid ventricular response. In patients who have atrial fibrillation with rapid ventricular response, a digitalis preparation should be used prior to institution of therapy with dobutamine. Patients with preexisting hypertension appear to face an increased risk of developing an exaggerated pressor response.
Participants with advanced or metastatic solid tumor and normal hepatic function will receive sacituzumab govitecan-hziy 10 mg/kg on Days 1 and 8. At the completion of study treatment, participants who are deriving benefit from sacituzumab govitecan-hziy may continue to receive treatment in a Gilead sponsored rollover study (IMMU-132-14; NCT04319198).
Introduction: Previous literature showed an association between hyperthermia and dexmedetomidine (DEX) use for ongoing sedation in non-obese patients. The purpose of this study is to evaluate DEX's effect on temperature in obese critically ill patients. Methods: This single center, retrospective, cohort study included patients ≥18 years, admitted to a surgical or medical ICU, received DEX for ≥8 hours as a single continuous infusion sedative, and weighed ≥120% of ideal body weight. Patients were excluded if they had a fever (≥38°C) and positive cultures within 48 hours of DEX initiation. The primary endpoint was a fever (Tmax of ≥38°C) within 48 hours of DEX initiation. Results: A total of 186 patients were included for evaluation. Forty-two patients (22.5%) had a fever during the first 48 hours of DEX initiation. Median weight was not different between the febrile and afebrile groups (99.4 [90.6-122.4] vs 97.6 [81.6-114.2] kg, P = .6). Median change from baseline temperature for all patients within 48 hours was an increase of .5 (.1-.8) °C, P < .001. In multiple regression analysis, duration of DEX and baseline temperature were the only significant predictors of fever development with an adjusted odds ratio of 1.041 (95% CI 1.009-1.074, P = .012) and 7.058 (95% CI 3.307-15.064, P < .001), respectively. Conclusions: This study suggests that there is a significant increase in body temperature from baseline for obese patients on DEX. Duration of DEX and baseline temperature were found to be risk factors for fever development in this population. Further studies are warranted.
Cells will be injected intradermally every 1 week x 4 weeks and then every 2 weeks for 10 immunizations to total 14 immunizations. Dose Cohort 1 will receive 150 million cells per immunization; Dose Cohort 2 will receive 300 million cells per immunization. Once the first three months of immunizations are completed, patients may receive other systemic treatment (non-investigational) while continuing to receive the remaining 6 immunizations.
FIELD: food industry and medicine, particularly, preparation of biologically active products. SUBSTANCE: method of preparing biologically active substances from velvet antlers includes their cleaning from cover, grinding and following extraction. Extraction is conducted by sugar-like syrup, mainly, fleur honey at temperature of water bath. Food additive containing biologically active substances is a sugar-like extract of velvet antlers prepared by method of extraction. Food additive containing biologically active substances is a hard residue of centrifugal separation of sugar-like extract of velvet antlers. Food additive containing biologically active substances is a liquid residue of centrifugal separation of sugar-like extract of velvet antlers. EFFECT: maximum preservation of biologically activity of used products; reduced labor intensity of process for preparing biologically active substances. 8 cl, 2 tbl, 3 ex
PURPOSE:To prepare novel antibiotic, oxirapentyn, by cultivating Beauveria felina SANK 13682 strain. CONSTITUTION:Beauveria felina SANK (FERM-P 6834) is cultivated in a common medium at approximately weak acidity or neutrality at 20-30 deg.C aerobically, to give novel antibiotic oxirapentyn shown by the formula. Oxirapentyn has the following characteristics. Color and shape of the substance: colorless rhombohedral crystal. Melting point: 114-115 deg.C. Molecular formula: C18H20O6. Molecular weight: 332. Solubility in solvents: soluble in methanol, ethanol, acetone, ethyl acetate, or chloroform, slightly soluble in water or n-hexane. Oxirapentyn has activity against Gram-positive bacteria, and is usable as an antibacterial agent for various kinds of microbisms.
Objective: Obstructive sleep apnea (OSA) is a sleep disorder accompanied by intermittent hypoxia. Neuromuscular transmission (NT) is known to be disturbed under chronic hypoxia. In this descriptive study, it has been aimed to test NT under intermittent hypoxia in OSA. Methods: Thirty-nine newly diagnosed OSA patients without any comorbidities or conditions that alter NT were included in the study. Jitter analysis was performed using a concentric needle electrode. Results: The mean jitter value of 39 OSA patients was 25.9 ± 3.7 μs. When compared to the mean reference jitter values, patients in the present study had significantly higher jitter (p < 0.001). Seven (17.9%) patients met the electrophysiological criteria for NT failure. Conclusion: The authors propose that intermittent hypoxia can be the trigger for NT failure in OSA. The interaction between increased oxidative stress and disturbed mitochondrial functions may also contribute.
Acute lower respiratory infections (ALRI) are the leading post-neonatal cause of death in children under 5 years old. There is a high prevalence of pediatric ALRI-related hypoxemia in low- and middle-income countries. The WHO defines clinically meaningful hypoxemia in children as a SpO2 (peripheral oxygen saturation) <90%. Multiple studies put this convention into question and found SpO2 of 90% to 92% to be associated with child ALRI mortality. An evolving body of evidence suggests that pulse oximeters systematically overestimate oxygen saturation in individuals with dark skin tones. We conducted a narrative review of pediatric studies evaluating pulse oximeter accuracy in children without COVID-19. Four studies, one prospective, examined pulse oximeter accuracy in children of varying ages with dark skin tones. All studies had limitations that affect their generalizability. There is evidence that certain pulse oximeters may overestimate oxygen saturation in children with dark skin tones. Further prospective research is urgently needed to identify affected populations and clinical implications. Despite recognized challenges, we strongly urge continued and expanded use of pulse oximetry as its use will save lives.
PCI with a biodegradable-polymer biolimus-eluting stent (Biomatrix stent) with 120 µm struts. During the PCI, an OCT assessment (baseline and post-implantation) will be performed.
A surface stabilized, non-agglomerated silica is provided. The silica is prepared by the method of providing non-agglomerated silica, and then treating the surface of the silica, thereby substantially preventing agglomeration of silica. The surface of the silica may be treated with a hydrophobating agent, such as a silane, or an alcohol. Different embodiments of the invention illustrate that the hydrophobating agent or alcohol can be added at different points within the process of forming the surface stabilized, non-agglomerated silica. The surface stabilized, non-agglomerated silica has a size in the nanometer range. The surface stabilized, non-agglomerated silica can be used as an additive in any application that uses silica, such as reinforcing fillers for elastomeric compositions, foods, drugs, dentifrices, inks, toners, coatings and abrasives.
Background & objectives Subclinical joint bleed is a matter of concern in individuals with hemophilia on prophylaxis. Ultrasonography (USG) is mostly used for the screening of subclinical bleeds in such individuals but it has its own limitations. Thus a more comprehensive technology is required for the detection of the same. This study undertook to evaluate the efficacy of infrared thermography (IRT) for detection of subclinical joint bleeds and its comparison with ultrasonography and MRI (Magnetic Resonance Imaging), considering MRI as the gold standard. Methods Forty eight asymptomatic individuals with hemophiliacs on prophylaxis and 15 healthy males as controls were recruited. IRT, USG and MRI were done in all participants included in the study. FLIR camera systems were used for the capture of thermograms of the joints in both the study groups. Results The mean of maximum temperature difference>0.5K (ΔT max >0.5K) as compared to a healthy joint was considered as significant. Subclinical bleeds were detected in 23.9, 7.29 and 27.08 per cent participants by IRT, USG and MRI respectively. Sensitivity and specificity of IRT and USG was detected to be 88.4 and 97.67 per cent, and 26.9 and 99 per cent, respectively. Interpretation & conclusions The findings of this study suggest that IRT is an effective tool for detection of subclinical joint bleeds in individuals with hemophilia and can be used for the monitoring of the joints in such individuals.
<P>PROBLEM TO BE SOLVED: To provide a food material having a high antiobestic effect or blood cholesterol level elevation inhibiting activity, and to provide a food and drink containing the food material.  <P>SOLUTION: This invention comprises the antiobestic agent comprising a component contained in cassis fruits as an active component. The invention comprises the food and drink comprising the component contained in the cassis fruits and having antiobestic activity and indicating that the component is used for suppressing or prophylaxis of obesity. The invention comprises a blood cholesterol level elevation inhibitor using the component contained in the cassis fruits as the active component. The invention compres the food and drink containing the component contained in the cassis fruits and having suppressing effect on the total blood cholesterol level and indicating that the content is used for suppressing the total cholesterol level.  <P>COPYRIGHT: (C)2006,JPO&NCIPI