anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Oxaprozin tablets, USP are a nonsteroidal anti-inflammatory drug, available as tablets of 600 mg for oral administration. The chemical name is 4,5-diphenyl-2-oxazole-propionic acid. The molecular weight is 293. Its molecular formula is C18H15NO3, and it has the following chemical structure.

Oxaprozin, USP is a white to off-white powder with a slight odor and a melting point of 162°C to 163°C. It is slightly soluble in alcohol and insoluble in water, with an octanol/water partition coefficient of 4.8 at physiologic pH (7.4). The pKa in water is 4.3. 

Oxaprozin tablets, USP contain 600 mg of oxaprozin, USP.

In addition, each tablet of oxaprozin, USP contains the following inactive ingredients: colloidal silicon dioxide, microcrystalline cellulose, hypromellose, methylcellulose, magnesium stearate, polacrilin potassium, starch, polyethylene glycol, titanium dioxide, and polysorbate 80.
PURPOSE: Optic pathway gliomas (OPGs) occur in 15% of patients with neurofibromatosis type 1 (NF1). Their location renders biopsy or surgical resection difficult because of the risk of vision loss. Therefore, only a few NF1-OPGs have been used for tissue diagnosis, and only a few analyses have been published on the molecular changes that drive tumorigenesis.
METHODS: Due to this reason, we evaluated 305 NF1 patients, 34 with OPG and 271 without OPG for germ line mutations. All subjects underwent clinical examination and DNA analysis of NF1, confirming the diagnosis of NF1.
RESULTS: Clinically, the group with OPG had a significantly higher incidence of bone dysplasia (P < 0.001) and more café-au-lait spots (P = 0.001) compared to those in the group without OPG. The frequency of Lisch nodules was on the borderline of statistical significance (P = 0.058), whereas the frequency of neurofibromas did not differ significantly (cutaneous, P = 0.64; plexiform, P = 0.44). Individuals with OPG mostly had mutations in the first one-third of the NF1 gene compared with that in patients who did not have OPG. Some identical mutations were detected in unrelated families with NF1-OPG.
CONCLUSION: The observation of certain phenotypic features and the correlation between genotype and phenotype might help to determine the risk of developing OPG with NF1.
During the intervention phase (phase B), all included participants will have 6 sessions of Goal Management Training (GMT; twice per week) in which two individual chosen IADL-tasks will be subdivided into multiple steps under guidance of a therapist using the GMT method. In addition participants play the compensatory brain game in which they are challenged to apply the learned GMT strategy in an imaginary and safe environment.
PURPOSE OF REVIEW: The process of neutrophil extracellular traps (NETs) formation, called NETosis, is a peculiar death modality of neutrophils, which was first observed as an immune response against bacterial infection. However, an ongoing and exaggerated NETs formation may have adverse clinical consequences and even promote cancer progression. This review will discuss the complex relationship between NETosis and cancer progression.
RECENT FINDINGS: NETs exhibits cancer-promoting effects by causing cancer metastaisis and tumor-associated thrombosis. Many studies have found that many mechanisms are involved in the process, and the corresponding targets could be applied for cancer therapy. Although NETs may have anti-bacteria effects, it is necessary to inhibit an excessive NETs formation, mostly showing cancer-promoting effects. The contribution of NETs to cancer progression has gained a growing appreciation and the approaches to targeting NETs deposition exhibited beneficial effects both in primary and metastatic tumors, which, however, has been challenged by a recent finding demonstrating an opposite effect of NETs to suppress tumor growth via the activation of immune response against tumor. This seeming discrepancy reflects we are in the early stage of NETs study facing fundamental questions and a better understanding of the underlying mechanism is urgently needed.
Novel analogues of calcitonin gene related peptide comprise analogues of natural CGRPs modified at at least two of positions 3, 22 and 25. These compounds are of general formula NH2?-Ala-Cys-A-aa?$g(a)-B-C-Lys-D-aa?$g(b)-CONH2?, wherein A is a carboxylate or amide substituted amino acid or amino acid analogue; aa?$g(a) is substantially the amino acid sequence of a CGRP from position 4 to position 21; B is a hydrocarbyl or thio substituted amino acid or amino acid analogue; C is valine or glycine; D is an amine or hydroxyl substituted amino acid or amino acid analogue. The novel analogues may comprise natural amino acid residues. Preferably A is aspartate or asparagine, B is valine or methionine, C is valine and D is asparagine or serine. The analogues exhibit desirable cardiovascular properties and are potentially useful in therapy, e.g. for treatment of deficiencies in cerebral blood supply.
A healthcare risk index is generated using a patient or individual's medical claims. The index may be used to explain and predict variation in pharmacy-related costs and variation in total healthcare costs or utilization. In particular, one example of such a method involves first generating a medical condition score using the individual's medical information for each medical condition possessed by the individual. From there, each medical condition score is modified according to a regression coefficient, to result in one or more modified medical condition scores. Finally, the risk index may be generated by summing the medical condition scores. This risk index is indicative of at least one of the individual's medical costs, chronic medical conditions, and variation in medical costs.
Children with a diagnosis of spastic CP aged 2 to 12 years who were referred due to chewing/swallowing problems by pediatric neurologists were included. The inclusion criteria were above the age of 24 months, and had complaints about chewing function. Children under the age of 24 months, requiring tube feeding or taking any oral nutritional supplements, and used any medicine and/or oral appliances that could affect the chewing performance, were excluded.
BACKGROUND: Elevated troponin levels are a sensitive biomarker for cardiac injury. The quick and reliable prediction of troponin elevation for patients with chest pain from readily available ECGs may pose a valuable time-saving diagnostic tool during decision-making concerning this patient population.
METHODS AND RESULTS: The data used included 15 856 ECGs from patients presenting to the emergency rooms with chest pain or dyspnoea at two centres in Sweden from 2015 to June 2023. All patients had high-sensitivity troponin test results within 6 hours after 12-lead ECG. Both troponin I (TnI) and TnT were used, with biomarker-specific cut-offs and sex-specific cut-offs for TnI. On this dataset, a residual convolutional neural network (ResNet) was trained 10 times, each on a unique split of the data. The final model achieved an average area under the curve for the receiver operating characteristic curve of 0.7717 (95% CI±0.0052), calibration curve analysis revealed a mean slope of 1.243 (95% CI±0.075) and intercept of -0.073 (95% CI±0.034), indicating a good correlation between prediction and ground truth. Post-classification, tuned for F1 score, accuracy was 71.43% (95% CI±1.28), with an F1 score of 0.5642 (95% CI±0.0052) and a negative predictive value of 0.8660 (95% CI±0.0048), respectively. The ResNet displayed comparable or surpassing metrics to prior presented models.
CONCLUSION: The model exhibited clinically meaningful performance, notably its high negative predictive accuracy. Therefore, clinical use of comparable neural networks in first-line, quick-response triage of patients with chest pain or dyspnoea appears as a valuable option in future medical practice.
Drospirenone is a spironolactone analogue with anti-mineralocorticoid and antiandrogenic activity. The estrogen in Drospirenone/Ethinyl Estradiol/Levomefolate Calcium is ethinyl estradiol (EE).

Contraception

No specific pharmacodynamic studies were conducted with Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium. 

Two studies evaluated the effect of 3 mg DRSP / 0.02 mg EE combinations on the suppression of ovarian activity as assessed by measurement of follicle size via transvaginal ultrasound and serum hormone (progesterone and estradiol) analyses during two treatment cycles (21-day active tablet period plus 7-day pill-free period). More than 90% of subjects in these studies demonstrated ovulation inhibition. One study compared the effect of 3 mg DRSP/0.02 mg EE combinations with two different regimens (24-day active tablet period plus 4-day pill-free period vs. 21-day active tablet period plus 7-day pill-free period) on the suppression of ovarian activity during two treatment cycles. During the first treatment cycle, there were no subjects (0/49, 0%) taking the 24-day regimen who ovulated compared to 1 subject (1/50, 2%) using the 21-day regimen. After intentionally introduced dosing errors (3 missed active tablets on Days 1 to 3) during the second treatment cycle, there was 1 subject (1/49, 2%) taking the 24-day regimen who ovulated compared to 4 subjects (4/50, 8%) using the 21-day regimen.

Acne

Acne vulgaris is a skin condition with a multifactorial etiology including androgen stimulation of sebum production. While the combination of EE and DRSP increases sex hormone binding globulin (SHBG) and decreases free testosterone, the relationship between these changes and a decrease in the severity of facial acne in otherwise healthy women with this skin condition has not been established. The impact of the antiandrogenic activity of DRSP on acne is not known.

Folate Supplementation

Two studies evaluated the impact of Drospirenone/Ethinyl Estradiol/Levomefolate Calcium and Levomefolate Calcium on plasma folate and RBC folate levels. A randomized, double-blind, active-controlled, parallel group study compared plasma folate and red blood cell (RBC) folate levels during a 24-week treatment with YAZ + 0.451 mg levomefolate calcium as compared to YAZ alone in a U.S. population. The pharmacodynamic effect on plasma folate, RBC folate, and the profile of circulating folate metabolites was assessed during 24 weeks of treatment with 0.451 mg levomefolate calcium or with 0.4 mg folic acid (equimolar dose to 0.451 mg levomefolate calcium), both in combination with 3 mg DRSP/0.03 mg EE (Yasmin) followed by 20 weeks of open-label treatment with Yasmin only (elimination phase). [See Clinical Studies (14.4).]
BACKGROUND: The purpose of this study was to explore the relevant risk factors associated with biliary complications (BCs) in patients with end-stage hepatic alveolar echinococcosis (HAE) following ex vivo liver resection and autotransplantation (ELRA) and to establish and visualize a nomogram model.
METHODS: This study retrospectively analysed patients with end-stage HAE who received ELRA treatment at the First Affiliated Hospital of Xinjiang Medical University between August 1, 2010 and May 10, 2023. The least absolute shrinkage and selection operator (LASSO) regression model was applied to optimize the feature variables for predicting the incidence of BCs following ELRA. Multivariate logistic regression analysis was used to develop a prognostic model by incorporating the selected feature variables from the LASSO regression model. The predictive ability, discrimination, consistency with the actual risk, and clinical utility of the candidate prediction model were evaluated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Internal validation was performed by the bootstrapping method.
RESULTS: The candidate prediction nomogram included predictors such as age, hepatic bile duct dilation, portal hypertension, and regular resection based on hepatic segments. The model demonstrated good discrimination ability and a satisfactory calibration curve, with an area under the ROC curve (AUC) of 0.818 (95% CI 0.7417-0.8958). According to DCA, this prediction model can predict the risk of BCs occurrence within a probability threshold range of 9% to 85% to achieve clinical net benefit.
CONCLUSIONS: A prognostic nomogram with good discriminative ability and high accuracy was developed and validated to predict BCs after ELRA in patients with end-stage HAE.
The invention relates to dust mite allergen Derf28 and genes and an application thereof, and belongs to the field of biomedicine. A new natural allergen Derf28 in a manner of separating and purifying from the dust mites is obtained, and encoding genes of the allergen are cloned. The dust mite allergen Derf28 disclosed by the invention comprises 659 amino acids. The first-stage structure of the amino acid sequence of the allergen is shown in SEQ ID No.1. The sequences of the encoding genes of the allergens comprise 1980 nucleotides, wherein the serial number of the gene nucleotide sequence in GenBank is KC305502. The dust mite allergen has the following beneficial effects that the dust mite allergen Derf28 and the genes thereof are provided, and the dust mite allergen Derf28 can be applied to preparation of drugs for treating dust mite anaphylactic diseases.
PURPOSE:To obtain a cement easily curable by hydration, having high uniformity and giving a cured product having high compressive strength by reacting a suspension of calcium hydroxide with an aqueous solution of phosphoric acid at a specific temperature and a specific final concentration of the reaction product and calcining the product. CONSTITUTION:A calcium phosphate cement is produced by wet-process comprising the reaction of a suspension of calcium hydroxide and an aqueous solution of phosphoric acid and the calcination of the resultant precipitate of calcium phosphate. The process is carried out as follows. A suspension of calcium hydroxide is made to react with an aqueous solution of phosphoric acid at 50-100 deg.C under a condition to give a final reaction product concentration of 5-25%. The obtained mixture of hydroxyapatite and calcium diphosphate is calcined to obtain the objective alpha-type calcium triphosphate cement. The cement gives a hydrated and cured product having extremely high compressive strength exceeding that of a dry-process cement obtained by the re-calcination under pressure.
This invention relates to an object-oriented system and method for easily and rapidly distributing medical images from existing picture and report storage systems to a plurality of heterogeneous client workstations. The system includes one or more interface engines, for providing image objects with uniform structure regardless of the type of existing system on which they are stored, and image server middleware, for managing the distribution of image objects. The system also includes a security object server, for authorizing user access to the image distribution system and to particular objects, a personalization object server, for providing user interface preferences and client workstation capabilities, and a web server, for downloading initial access pages and user interface components. The system implements a method for medical image distribution according to which image data stored in existing picture storage systems is first converted into a uniformly structured image objects before being composed for downloading to client workstations for user viewing. The system and method of this invention are easily extensible both for added function and for added performance. The system and method of this invention are preferably implemented according to CORBA standards.
PURPOSE: To investigate differences in intraocular structure based on the presence or absence of fixation preference in children with intermittent exotropia (IXT) by comparing the thickness of the retinal nerve fiber layer (RNFL).
METHODS: From October 2018 to March 2022, RNFL thickness was retrospectively analyzed using spectral domain optical coherence tomography. Participants had uncorrected visual acuity of 20/20, refractive errors close to emmetropia, and no anisometropia. The patients were divided into monocular and alternating exotropia groups through a cover-uncover test. The average and sectoral thickness of the RNFL in both groups were compared.
RESULTS: The average global thickness and average thickness of each of the six sectors of the RNFL did not significantly differ between dominant and non-dominant eyes in the monocular exotropia group and between right and left eyes in the alternating exotropia group. The thickness did not significantly differ between the monocular exotropia group and the right or left eye of the alternating exotropia group. Interocular differences in RNFL thickness were negative in the monocular exotropia group (dominant eye-non-dominant eye) and positive in the alternating exotropia group (right eye-left eye) for the average, inferonasal, and inferior sectors, exhibiting statistically significant between-group differences (p = 0.019, p = 0.003, p = 0.023, respectively).
CONCLUSIONS: In children with IXT without obvious refractive error, there was a significant interocular difference in RNFL thickness of the average, inferonasal, and inferior sectors between monocular and alternating exotropia groups. The presence of fixation preference may affect RNFL thickness.
We will determine the utility of a novel brain mapping technique for epilepsy presurgical evaluation, referred to as 'six-dimensional (6D) dynamic tractography'. This innovative program animates the rapid neural propagations along MRI-defined, 3D white matter tracts that connect regions supporting cognitive functions. Specifically, it will use event-related high gamma activity to localize the regions supporting specific linguistic functions and compute the velocity and strength of neural propagations based on the latency and amplitude of early neural responses to single-pulse electrical stimulation. We expect that considering both the negative effect of damaged white matter tracts and the positive effect of seizure control will help optimize the model's performance in predicting postoperative language outcomes; this will be accomplished by incorporating the 6D dynamic tractography and objective epilepsy biomarkers, including spontaneous high-frequency oscillations (HFOs) coupled to slow-waves, into our predictive model. By also identifying and considering the physiological high gamma augmentation strictly time-locked to stimuli and behaviors, our innovative intracranial EEG analysis will better distinguish the randomly-occurring pathologic HFOs. Another significant advancement provided by our model is its independence of conventional electrical stimulation mapping, which can acutely elicit seizures and fail to satisfactorily localize language areas in certain patient subsets. Additionally, this project will use 6D dynamic tractography to provide an explicit neurobiological model of language network dynamics, allowing us to tease apart the specific pathways originating from temporal lobe cortices that support the lexical retrieval of auditory or visual domains. Our prior project indicated that the arcuate fasciculus fibers support the direct transfer of lexical representations of auditory sentences. We will now determine whether the lexical representations of visual objects are likewise transferred via the arcuate fasciculus or others, including the fusiform-parietal fasciculus. To accomplish these goals, this project will prospectively recruit a new cohort of 80 epilepsy patients - age range: 0.5 to 21 years - undergoing extraoperative intracranial EEG recording and subsequent resective surgery. Finally, we will determine if the human brain creates and strengthens language-related functional parcellations throughout development. It has been suggested that the adult brain efficiently activates the posterior superior-temporal gyrus (STG) only during sound onset to decode the boundary between sounds. In contrast, the anterior STG shows sustained activation during an auditory stimulus to encode the phonetic features. We will determine if such a functional parcellation is more evident in older individuals, whose brains are more developed. While providing hypotheses focusing on specific brain regions, we will perform all of the proposed analyses at the whole-brain level. We will make all data and codes publicly available to facilitate external validation and implementation.
This study was planned as a randomized controlled trial in order to determine the effect of creative drama training for alcohol-substance dependent male patients on their attitudes towards violence against women.

The study was planned to be fully experimental. The participants to be included in the study will be selected from men who are followed up with a diagnosis of addiction in a mental health hospital. In the experimental group, male patients will be given violence against women training supported by creative drama five days a day. It will be used as an improved scale-measuring tool for women before and after the training. In the control group, the trainings applied in the service operation will be applied. It will be used as an improved scale-measuring tool for women before and after the training.
A prescription medicine packaging system includes cells. Each cell stores prescription medicine. Each cell has an opening adapted for access by a user. A cap is aligned over and seals each opening. Each cap includes a first part and a second part that are independent of one another and uniquely identifiable by features thereof. Each of the caps is breached via one of removal and destruction of one of its first part and second part.
Rehabilitation of arm impairment after stroke includes the repetitive practice of functional tasks. In healthy adults, planning plays a vital role in the control of skilled movement, however, the behavioral and neural correlates of planning have largely been unexplored in individuals recovering from stroke. Action selection is an important motor planning process that engages dorsal premotor cortex (PMd) in controls. While PMd activation is a commonly reported neural correlate of motor recovery after stroke, the role of PMd in action selection and motor training are not known. Therefore, the purpose of this study is to determine the effect of training that includes action selection demands on the behavioral and neural correlates of movement after stroke. Thirty-eight individuals in the chronic phase of stroke will be recruited. After completion of clinical measures of impairment and function, all participants with stroke will complete a motor action selection task and functional MRI followed by arm training. Arm training will consist of three weeks (15 sessions) of arm motor training (1.5 hours per session) that includes action selection demands on movement. Follow-up clinical testing will occur at the end of treatment and three weeks later.