anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Nonspecific Orbital Inflammation (NSOI) remains a perplexing enigma among proliferative inflammatory disorders. Its etiology is idiopathic, characterized by distinctive and polymorphous lymphoid infiltration within the orbital region. Preliminary investigations suggest that PALMD localizes within the cytosol, potentially playing a crucial role in cellular processes, including plasma membrane dynamics and myogenic differentiation. The potential of PALMD as a biomarker for NSOI warrants meticulous exploration.
METHODS: PALMD was identified through the intersection analysis of common DEGs from datasets GSE58331 and GSE105149 from the GEO database, alongside immune-related gene lists from the ImmPort database, using Lasso regression and SVM-RFE analysis. GSEA and GSVA were conducted with gene sets co-expressed with PALMD. To further investigate the correlation between PALMD and immune-related biological processes, the CIBERSORT algorithm and ESTIMATE method were employed to evaluate immune microenvironment characteristics of each sample. The expression levels of PALMD were subsequently validated using GSE105149.
RESULTS: Among the 314 DEGs identified, several showed significant differences. Lasso and SVM-RFE algorithms pinpointed 15 hub genes. Functional analysis of PALMD emphasized its involvement in cell-cell adhesion, leukocyte migration, and leukocyte-mediated immunity. Enrichment analysis revealed that gene sets positively correlated with PALMD were enriched in immune-related pathways. Immune infiltration analysis indicated that resting dendritic cells, resting mast cells, activated NK cells, and plasma cells positively associate with PALMD expression. Conversely, naive B cells, activated dendritic cells, M0 and M1 macrophages, activated mast cells, activated CD4 memory T cells, and naive CD4 T cells showed a negative correlation with PALMD expression. PALMD demonstrated significant diagnostic potential in differentiating NSOI.
CONCLUSIONS: This study identifies PALMD as a potential biomarker linked to NSOI, providing insights into its pathogenesis and offering new avenues for tracking disease progression.
A group of 19 patients will be tested using the 30 seconds Sit-to-stand and Timed up and go tests. Each test will be repeated 3 times and the best score will be used. There is going to be 3 days waiting period before the re-tests.
Staphylococcus aureus (S. aureus) infection is the most prevalent and resistant bacterial infection, posing a worldwide health risk. Compared with healthy people, diabetes patients with weak immune function and abnormal metabolism are more vulnerable to bacterial infection, which aggravates the intensity of infection and causes a series of common and dangerous complications, such as diabetes foot ulcer (DFU). Due to metabolic abnormalities of diabetic patients, S. aureus on the skin surface of DFU transitions from a commensal to an invasive infection. During this process, S. aureus resists a series of unfavorable conditions for bacterial growth by altering energy utilization and metabolic patterns, and secretes various virulence factors, causing persistent infection. With the emergence of multiple super-resistant bacteria, antibiotic treatment is no longer the only treatment option, and developing new drugs and therapies is urgent. Regulating the metabolic signaling pathway of S. aureus plays a decisive role in regulating its virulence factors and impacts adjuvant therapy for DFU. This article focuses on studying the impact of regulating metabolic signals on the virulence of S. aureus from a metabolism perspective. It provides an outlook on the future direction of the novel development of antimicrobial therapy.
Antineoplasmic and anticellulitic pharmaceutical compositions comprise a pharmaceutical carrier and plant extract which is the aqueous suspension obtained by extractively distilling with boiling water the roots, stems, leaves, flowers or seeds of plants of the Nympheaceae family (Water Lilies), and condensing and collecting the distilling vapours.  The preferred plant is Nymphea alba, and the extract is most suitably derived from the ground seeds.  The distillate may be mixed with, or preferably collected in, one or more, other essential oils, such as oils from Cruciferaceae (mustard oil, or horseradish oil) and from Liliaceae (garlic oil); these oils are said to contain, respectively, allyl isosulphocyanide, allyl disulphides and allyl propyl disulphides, and also peroxidase.  The mixed oils are preferably irradiated with monochromatic light, by exposing them to sunlight under coloured glass filters.  The compositions may be for oral, parenteral, or external application, in the form of solutions or suspension in olive-or hempseed-oil, aqueous suspensions, powders, or rectal irrigations.  Compositions containing vitamins B1 and C are disclosed.
The purpose of this study is to prove: (1) hypertensive response at rest and provoked by stress are decreased by EA; (2) The mechanisms of EA that reduces elevated blood pressure. EA inhibits the sympathetic nervous system, decreases blood pressure and reduces the oxygen demand. Our prior data in animals shows that improvements in cardiovascular function during myocardial ischemia, reflex hypertension and sustained hypertension are mediated by an EA-induced sensory neural reflex originating in somatic nerves to reduce sympathetic nerve activity. The specific aims of the present study will allow us to better understand and modulate the sympathetic nervous discharge activity that can cause hypertension during normal activity and stress in humans. The potential clinical application is the therapeutic value of EA in patients with hypertension.

Furthermore, the study will also investigate gender differences in the blood pressure lowering effect of EA. In particular in middle-aged hypertensive women and men.
The invention provides a porcine delta coronavirus genetic engineering subunit vaccine and application thereof, and relates to the field of biological products for livestock. The porcine delta coronavirus gene engineering subunit vaccine comprises recombinant PDCoV-S protein or recombinant PDCoV-RBD protein; the amino acid sequence of the recombinant PDCoV-S protein is shown as SEQ ID No. 1; the amino acid sequence of the recombinant PDCoV-RBD protein is shown in SEQ ID No. 2. The recombinant protein expressed by the baculovirus expression system is simple and convenient in purification process and convenient for large-scale production. The porcine delta coronavirus gene engineering subunit vaccine prepared by the method fills the blank that the porcine delta coronavirus subunit vaccine is not available at home and abroad, and can be used for preventing the infection of the porcine delta coronavirus.
Patients who are fitted with a Gellhorn pessary for reduction of pelvic organ prolapse. Patients will then be randomized based on pessary to either Estradiol vaginal cream or Placebo vaginal cream. Patients will be instructed to digitally apply 0.5mg of cream inside vagina every night for 2 weeks. After 2 weeks they will switch to 2 nights weekly.
A protein called prostate six transmembrane epithelial antigen 2 (STEAP 2) is highly expressed in prostate cancer and is associated with the expression of other prostate cancer related genes. The present invention provides novel full length human IgG antibodies (monospecific antibodies) that bind to human STEAP 2. The invention also provides novel bispecific antibodies (bsAb) that bind to both STEAP2 and CD3 and activate T cells via CD3 complexes in the presence of STEAP2 expressing tumors. According to certain embodiments, the present invention provides bispecific antigen binding molecules comprising a first antigen binding domain that specifically binds human and monkey CD3 and a second antigen binding molecule that specifically binds human STEAP 2. In certain embodiments, the bispecific antigen binding molecules of the invention are capable of inhibiting the growth of a tumor that expresses STEAP 2. The bispecific antigen binding molecules of the invention are suitable for use in treating prostate diseases and conditions where upregulated or induced STEAP 2-targeted immune responses are desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention can be used to treat prostate cancer, including castration-resistant prostate cancer. The invention also comprises anti-STEAP 2 antibody drug conjugates that inhibit tumor growth in vivo.
Patients will receive a combination therapy of tucatinib with pembrolizumab and trastuzumab during the treatment period until progression, treatment intolerance, or patient withdrawal from study. Tucatinib and pembrolizumab are administered as experimental use while trastuzumab is administered per standard use. Patients are expected to be on treatment for at least 12 weeks.
Worldwide, iron deficiency is the most common shortage in women of childbearing age and also the most common cause of anemia. The prevalence of iron deficiency in young not pregnant women is 10-30%. During pregnancy take Frequency and importance of iron deficiency. Through organic growth and development of fetoplacental Unit and by maternal tissue formation, uterus growth and strong Expansion of maternal blood volume increases the pregnant woman the iron requirement for a Multiple. Starting from a non-pregnant state in the daily requirement of about 1 mg increasing this to 4-5 mg. Even with optimum food selection and a secured Increase of intestinal absorption in pregnancy, there is a negative Iron balance. The consequences are a depletion of iron stores (Serum ferritin \<15 mcg / L) and a qualitative and quantitative disturbance of maternal Erythropoiesis with increased hypochromic and microcytic erythrocytes up to the occurrence anemia. The increased iron requirement is the background to a general recommendation an iron prophylaxis during pregnancy. However, this is possible due Reinforcement of gastrointestinal symptoms usually only from the 12th week of pregnancy is recommended. All pregnant women receive from the 12th week of pregnancy a multivitamin supplementation for the most important trace elements and vitamins. According to the guidelines of the Department of Obstetrics of USZ should a pregnant woman after the 12th week of pregnancy at a marginal ferritin \<50mcg / l prophylactically receive additional iron and so anemia can be prevented. The aim of the study is on the one hand today's conventional iron supplements Maltofer Fol and Gyno-Tardyferon to examine their effectiveness, in particular with regard to the difference between two- and trivalent iron. On the other hand are at the usual multivitamin supplements. Women with normal iron stores at the beginning with respect to their effectiveness in preventing a depletion of these stores will be examined. Another aspect to be examined the occurrence of manifest iron deficiency anemia among called iron prophylaxis.

According to ferrtin value at first pregancy check, patients are enrolled after informed consent.

ferritin \>50 mcg/L means patient will be randomized in eiter iron sulfate or iron polymaltose group. Ferritin \> 50 mcg/L means pt will reeive multivitamin - multimineral containing iron. At midpregancy ferritin value is routinely checked as well at entering delivery floor at term.
An association between periodontal disease and the development of pancreatic cancer has been pointed out since before. Advances in genome analysis technology have revealed that a pancreatic cancer-specific microbiome is formed in the intestines and tumors of pancreatic cancer patients and modifies the progression of pancreatic cancer. Disturbance of microbiome( dysbiosis)suppresses anti-tumor immunity against pancreatic cancer, promoting cancer progression. Therefore, attempts are being made to correct dysbiosis by administration of probiotics or transplantation of microbiome, which is especially activating immune checkpoint inhibitors against cancer. In addition, specific intratumor bacteria has been identified that create an immunosuppressive microenvironment through crosstalk with pancreatic cancer cells. In the future, analysis of the microbiome distribution in pancreatic cancers may determine the following treatment strategy as an individualized treatment. We hope that innovations in omics technology will reveal more detailed functions of microbiome and lead to the development of effective treatments for pancreatic cancer.
Participants randomly assigned to this arm will receive 6 packs of a 21 day oral contraceptive pill (OCP) called Yasmin (3 mg Drospirenone/0.03 mg Ethinyl estradiol) which has 21 days of active hormone and 7 days of sugar pills. Participants will take one pill daily for 6 months and be expected to take the sugar pills at the end of each monthly pack prior to starting a new pack.
Monosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment in myeloid malignancies with a del(7q). However, the rarity of "second hit" mutations supports the idea that del(7q22) represents a contiguous gene syndrome. We generated mice harboring a 1.5 Mb germline deletion of chromosome band 5G2 syntenic to human 7q22 that removes Cux1 and 27 additional genes. Hematopoiesis is perturbed in 5G2+/del mice but they do not spontaneously develop hematologic disease. Whereas alkylator exposure modestly accelerated tumor development, the 5G2 deletion did not cooperate with KrasG12D, NrasG12D, or the MOL4070LTR retrovirus in leukemogenesis. 5G2+/del mice are a novel platform for interrogating the role of hemopoietic stem cell attrition/stress, cooperating mutations, genotoxins, and inflammation in myeloid malignancies characterized by monosomy 7/del(7q).
PURPOSE:To enable mass production of a yellow pigment which is useful as a food additive because it is soluble in water, resistant to heat and light, stable in alkaline conditions and high in safety by culturing a mold strain in Epicoccum in a medium and separating and recovering the pigment accumulated in the medium. CONSTITUTION:A mold strain of Epicoccum, for example, Epicoccum nigrum sp-RDM-Y (FERM No. 12893) is inoculated with a platinum spatula to an enriched medium containing yeast essence and subjected to shaking culture at 25 deg.C for 7 to 10 days. Then, the culture liquid is centrifuged to separate into the supernatant and the cell bodies, the cell bodies are extracted with methanol and the extract and the supernatant are combined and subjected to ultrafiltration to remove high-molecular-weight components. Then, the filtrate is subjected to reverse osmosis to remove salts and low-molecular-weight components, the concentrate is passed through a adsorption resin column and the column is washed. Then, the adsorbate is eluted with 0.01% sodium hydroxide aqueous solution and the eluate is adjusted in its pH to 2.5 to 3.0 with hydrochloric acid to precipitate the yellow pigment, which is collected, dried to give the final product.
PURPOSE:To obtain a natural substance-derived antioxidant excellent in safety and having an antioxidizing power stronger than that of alpha-tocopherol. CONSTITUTION:The seed coat of a chestnut is pealed off and subsequently cut into fine pieces by using scissors. After adding water thereto and extracting it under. heating, the extract solution is separated from the residue. The residue of the hot water extraction is immersed in methanol at room temperature so as to extract remaining oil-soluble components. The methanol extract solution is subjected to distillation under a reduced pressure to obtain a methanol extract. A part of the hot water extract solution is distilled off under a reduced pressure to obtain a hot-water extract. After the residual hot water extract solution is concentrated under a reduced pressure, it is extracted with ethyl acetate. The obtained ethyl acetate layer is distilled off under a reduced pressure to obtain an ethyl acetate soluble fraction. The aqueous layer is concentrated under a reduced pressure and ethanol is subsequently added thereto. Insoluble materials are filtered and the filtrate is subsequently distilled off under a reduced pressure to obtain an ethanol soluble fraction. The filtered deposit is air-dried at room temperature to obtain a residual fraction. Each of the extracts and the fractions has an antioxidizing activity stronger than that of alpha-tocopherol which is the conventional antioxidant.
Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and absorption. The development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions, such as gastroparesis and irregular bowel habits, primarily due to disruptions in the function of neuronal and glial cells within the ENS, as well as oxidative stress and inflammation. This editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic patients. Additionally, it discusses the latest advances in diagnostic approaches, emphasizing the need for early detection and intervention to mitigate GI complications in diabetic individuals. The editorial also reviews current and emerging therapeutic strategies, focusing on pharmacological treatments, dietary management, and potential neuromodulatory interventions. Ultimately, this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes, aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.
The choice of first-line treatment is based on the guidelines, and may include chemotherapy or immune checkpoint inhibitors, or a combination of therapies. For patients who can tolerate cisplatin, chemotherapy is given with the gemcitabine-cisplatin regimen, as follows: gemcitabine 1000mg/m2 d1,8; cisplatin 70 mg/m2, avoiding light, intravenous drip d2; 3 weeks for 1 cycle. For intolerant patients, the gemcitabine-carboplatin regimen is given as follows: gemcitabine 1000 mg/m2 d1,8, IV, carboplatin (4.5×\[GFR+25\]) mg, IV, d1; 3 weeks as 1 cycle. Immune checkpoint inhibitors and targeted agents may be administered if the patient does not tolerate chemotherapy; either in combination with chemotherapy or directly as first line.
BACKGROUND: We evaluated the outcomes of pregnancy in women with congenital heart disease (CHD) and their offspring in Taiwan. We also investigated how different severity levels may influence the outcomes.
METHODS: We used data (2009-2017) from the Birth Certificate Application database in Taiwan, which is linked to the National Health Insurance Research Database and Taiwan Maternal and Child Health Database. We identified 2990 women with CHD who had 4227 births. Based on the CHD subtypes, patients were further divided into "severe CHD" and "simple CHD" groups.
RESULTS: Women with CHD have a significant risk of stillbirth. In maternal cardiac events, they had the highest risk of heart failure, followed by arrhythmia. The severity of CHD had a significant effect on the outcomes as well. The neonatal birth event that mothers with CHD have the highest risk of is preterm birth at < 32 weeks of gestation. The prominent difference in neonatal morbidities between mothers with severe and simple CHD is recurrent CHD in the offspring. The offspring of the severe CHD group had a higher risk of severe CHD, whereas those of the simple CHD group had a higher risk of simple CHD.
CONCLUSION: During pregnancy, the monitoring of heart function and cardiac rhythm could be more intensive in mothers with CHD. In addition to accurately assessing fetal growth and development during antenatal care, mothers with severe CHD should be provided with careful fetal heart structure assessment and genetic testing along with counseling.
Phentermine hydrochloride USP is a sympathomimetic amine anorectic. Its chemical name is α,α,-Dimethylphenethylamine hydrochloride. The structural formula is as follows:

C10H15N•HCl M.W. 185.7

Phentermine hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether.

Phentermine hydrochloride, an anorectic agent for oral administration, is available as a capsule containing 37.5 mg of phentermine hydrochloride (equivalent to 30 mg of phentermine base).

In addition, each capsule contains the following inactive ingredients: lactose monohydrate, magnesium stearate and talc. The capsule shell is composed of D&C Red No. 33, FD&C Blue No.1, titanium dioxide and gelatin. The imprinting ink contains: shellac glaze in ethanol, iron oxide black, n-butyl alcohol, propylene glycol, ethanol, methanol, D&C Yellow No. 10 Aluminum Lake, FD&C Blue No.1 Aluminum Lake, FD&C Blue No.2 Aluminum Lake and FD&C Red No. 40 Aluminum Lake.
Furosemide binding to albumin may be reduced in elderly patients. Furosemide is predominantly excreted unchanged in the urine. The renal clearance of furosemide after intravenous administration in older healthy male subjects (60 to 70 years of age) is statistically significantly smaller than in younger healthy male subjects (20 to 35 years of age). The initial diuretic effect of furosemide in older subjects is decreased relative to younger subjects. ( .) PRECAUTIONS:Geriatric Use
BACKGROUND: Flaps have become an integral part of plastic and reconstructive surgery. The robust blood supply of such flaps is a prerequisite to reduce flap failure. Despite the reported versatility of the occipital flap, comprehensive anatomical studies on its perforators and perforasomes are lacking. Hence, we examined the perforators originating from the occipital artery and their associated perforasomes, aiming to fill this knowledge gap for reconstructive surgery techniques.
METHODS: 39 of 40 occipital arteries of 20 fresh anatomical head specimens were dissected. Perforators with a least an outer diameter of 0.50 mm were identified and injected with dye to color their respective perforasomes. Location and size of the colored skin areas were determined as well as the location of their perforators were documented and analyzed.
RESULTS: In total, 183 perforators were found and described. The mean diameter of these vessels was 0.88 ± 0.27 mm (0.5-2.1 mm). The mean area of the perforasomes was 1288.26 ± 662.51 mm2 (144.60-3890.60 mm2). They were localized over the whole nuchal and occipital area. Lastly, perforator diameters were significantly associated with the size of their resulting perforasomes.
CONCLUSION: This study is the first comprehensive overview of perforators and associated perforasomes of the occipital artery on a respectable amount of specimen. The arterial supply of big portions of the occipital and nuchal area is provided solely by the perforators of the occipital artery. For flap surgery, perforator diameter is a crucial detail to be considered in the decision-making process.