anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To provide an aq. gel compsn. which has good storage stability and thixotropic properties, can be readily wiped out after coating, has a proper yield value and is suitable for use in preventing tooth decay by a tray method, containing a composite of a water-soluble anionic high-molecular gum and crystalline cellulose and a fluorine-contg. component as essential components. CONSTITUTION:A compsn. contains a composite obtd. by intimately combining a water-soluble anionic high-molecular gum with crystalline cellulose, and a fluorine-contg. component as essential components and optionally, a pH adjustor and additives. Examples of the water-soluble anionic high-molecular gum are cellulose derivatives and natural gum, and sodium carboxymethylcellulose is particularly preferred. Crystalline cellulose can be obtd. by the acidic hydrolysis of cellulose or the oxidative decomposition of cellulose with an alkali. Examples of the fluorine-contg. components are potassium fluoride and sodium fluoride. As said pH adjustor, phosphoric acid and/or its salts are preferred.
Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
PURPOSE:To obtain an enzyme-containing solid preparation stable under severe conditions of such as pressure, heat and moisture, by dissolving an enzyme together with dextrin, starch or their derivatives, and drying the obtained mixed solution. CONSTITUTION:A solution containing an enzyme (e.g. protease) and dextrin (e.g. amylodextrin), starch (e.g. corn starch), or their derivative (e.g. hydroxyethyl starch) is dried, and if necessary, an additive is added to the dried product to obtain the objective enzyme-containing preparation. The amount of dextrin, starch or their derivative is preferably about 0.1-10pts. per 1pt. of the enzyme, and the components are not necessarily dissolved completely. The solvent is usually water, however, a mixture of water and a hydrophilic organic solvent (e.g. acetone) may be used. The drying of the solution can be carried out by the conventional process for the drying of enzyme, e.g. freeze-drying, spray-drying, etc.
PURPOSE: To investigate the expectations regarding physiotherapists of patients attending an interdisciplinary CLBP rehabilitation programme and the response to these expectations.
MATERIALS AND METHODS: A thematic analysis was conducted, based on interviews of working-age patients with CLBP and without significant comorbidities.
RESULTS: Twenty patients participated (9 male, 11 female, aged 21-58 years; symptoms duration 4.3 ± 3.0 years; pain VAS 53 ± 21 mm). Patients expected to learn pain and activity management. Expected outcomes were a reduction of pain, increased well-being and a return to normality. A collaborative approach involving therapeutic and relational adaptation was expected. Despite divergences concerning emotional aspects, patients expected a large range of applied psychosocial skills.The programme met the expectations of most patients, especially when its goals matched those reported by the individuals. For most participants, the pain relief was below expectations. Active therapies were valued. After the programme, patients felt more ready to take responsibility for their back.
CONCLUSION: The expectation of developing self-management skills was prevalent. Expected treatments were mostly compatible with recommendations. Expectations to resume activities and decrease pain were in line with the rehabilitation goals, although the expected reduction in pain was overestimated. Relational expectations converged towards patient-centred care.
In the experimental arm (arm A), a total of 11 sessions of acupuncture will be performed on a weekly basis, spanning from 2 weeks before Radiotherapy start throughout 7 weeks of treatment, to 2 weeks after its completion. Patients randomized to the experimental arm will receive acupuncture in addition to standard of care treatment, chosen by the treating multidisciplinary team in accordance with international guidelines.
FIELD: medicine, pharmacy. SUBSTANCE: invention claims a tablet for a single oral administration of drug in colon intestine. Tablet has an internal core at amount 10-45% of tablet mass, surrounding labile polymeric layer and an enterosoluble envelope that surrounds its. Internal core has the biologically active compound and a pharmaceutically acceptable carrier. Labile polymeric layer has 30-85% of tablet mass and its thickness is 2-3.5 mm. It is made of the pharmaceutically acceptable derivative of cellulose ester and viscosity of its 2 wt.-% solution is 3-100 sP. Enterosoluble envelope has 5-25% of tablet mass and its thickness is about 50-300 mcm. Labile polymeric layer can include microcrystalline cellulose additionally at mass ratio of derivative of cellulose ester to microcrystalline cellulose from 6:1 to 0.5:1. The preferable derivative of cellulose ester is hydroxypropylcellulose, hydroxypropylmethylcellulose or their mixture. Invention ensures to deliver drugs in colon intestine without use of enema medicinal forms. EFFECT: enhanced effectiveness of the composition. 5 cl, 3 dwg, 2 ex
The present invention discloses a compound of Formula I or pharmaceutically acceptable salt thereof and its preparation method and applications. The new structure of the compound of formula I has not been reported in literature. The compound of formula I is isolated from  Isodon forrestii var. forrestii  and is a compound functioning as a Trxl selective inhibitor. The present invention further discloses a pharmaceutical composition, preparation of the compound of Formula I and its use for preventing or treating cancer. Iso A of the present invention has the advantages of low toxicity, high safety and strong pharmacological effect, which suggests a potential prospect in pharmaceutical applications.
The study included 60 patients with an established diagnosis IBS and FD. Patients were randomized in toone of three groups. Patients in group 1 received Trimedat (trimebutine, marketing authorization number LP-005534/07 of 2007-12-28) for 2 months, patients in group 2 received Trimedat and Rebagit (rebamipide, marketing authorization number LP-001831 of 2012-09-12) for 2 months, patients in group 3 received Rebagit for 2 months. The patients were blinded to the treatment assignment. At inclusion and 1 month after the severity of complaints were assessed, 2 months after starting treatment, the severity of complaints, quality of life, state of tight junction proteins, mucin-2 expression level, serum zonulin level, histological investigation of the mucous membrane of the small and large intestine, state of the intestinal microbiota and short-chain fatty acid levels were assessed. After the end of the study, an interim analysis of the effect of the therapy on the parameters was carried out. In the case of a positive effect, a full analysis of all the aforementioned factors contributing to its development was to be performed.

In addition, all these parameters were also in the control group (15 healthy volunteers without complaints, matched for sex and age with the main group).
BACKGROUND: There is limited knowledge about the impact of painful temporomandibular disorders (TMDs) and pain characteristics on jaw functional limitation and oral health-related quality of life (OHRQoL) in TMD patients.
OBJECTIVES: The influence of painful TMDs and pain characteristics on jaw functional limitation and OHRQoL was investigated. Inter-relationships between limitation in jaw function and various OHRQoL domains, along with facial pain attributes predicting impaired jaw function and diminished OHRQoL were also examined.
METHODS: TMD patients were recruited from a university-based hospital. A comprehensive questionnaire comprising demographic variables, the DC/TMD Symptom Questionnaire, Graded Chronic Pain Scale, Jaw Functional Limitation Scale-8 (JFLS-8) and Oral Health Impact Profile-TMD (OHIP-TMD) was administered. Participants underwent a protocolized physical examination, and TMD diagnoses were determined utilising the DC/TMD algorithms. Participants were subsequently stratified into intra-articular/pain-related/combined TMD groups, as well as no TMD pain, acute/chronic pain and low/high-intensity pain groups. Data were assessed using non-parametric and hierarchical linear regression analyses (α = .05).
RESULTS: The final sample consisted of 280 participants (mean age 31.2 (SD 11.8) years; 79.3% women). Significant differences in pain characteristics, JFLS-8, and global OHIP scores were observed across the various TMD subtypes, pain chronicity and pain intensity categories. Pain intensity and pain-related interference exhibited moderate correlations with JFLS-8 and global OHIP scores (rs = 0.53-0.60). Moderate associations were also noted between JFLS-8 and global OHIP, as well as most OHIP domains (rs = 0.42-0.64). Both jaw functional limitation and OHRQoL were predicted by sex, pain intensity and pain-related interference.
CONCLUSIONS: Sex, pain intensity and pain-related interference are key determinants for both impaired jaw function and diminished OHRQoL, with pain-related interference exerting a more pronounced effect.
Vascular refill is central to the initial management of hypotension in sepsis, and is often started even before the patient is admitted to intensive care. Over the past 20 years, we have moved from ultraliberal fluid resuscitation to restrictive resuscitation. Indeed, in the early 2000s, the implementation of an early and aggressive hemodynamic optimization strategy, including liberal vascular filling, improved the survival of critically ill patients, and ushered in the era of the Surviving Sepsis Campaign. However, studies have shown increased morbidity and mortality associated with a positive fluid balance. Restrictive approaches to fluid resuscitation and/or deressuscitation were then tested. While these approaches failed to demonstrate any benefit in terms of mortality, they did have the merit of demonstrating their feasibility and good tolerability, albeit with a little-explored pathophysiology. Little is known about the problem of dilutional anemia in the acute phase of septic shock.
The invention discloses a fish rhabdovirus attenuated vaccine strain and application thereof. The invention screens out a low virulent strain through a fish body challenge experiment, and the low virulent strain is named as a micropterus salmoides rhabdovirus trihydrate strain (MSRV-SS). The low virulent strain is proved to have immunoprotection to both mandarin fish and marble goby through fish body immunity experiment. Purifying the low virulent strain through plaque cloning to obtain a pure clone strain MSRV-SS-7, measuring the growth curves of the clone strain and the wild virus MSRV-SS on a mandarin brain tissue (CPB) cell line, and finding that the clone strain and the wild virus MSRV-SS have similar in vitro growth characteristics. The cloned strain MSRV-SS-7 is verified to have good immunogenicity. The screening of the low virulent strain and the sequencing of the whole genome thereof provide technical support for constructing a reverse genetic operation system of MSRV-SS-7 and developing a vector live vaccine.
Repara® Silver Nitrate Applicators must not be used for genital warts. Continued application to mucous membranes and open wounds leads to argyria, a blush-black discoloration of the skin due to depositions of granules of silver compounds in the connective tissues. This condition persists indefinitely or disappears very slowly. Poisoning by oral ingestion is unlikely with the quantities involved, but treatment for poisoning is the immediate ingestion of large amounts of salt water followed by an emetic. Then administer a dose of Epsom salts followed with milk. Immediately call a physician.
BACKGROUND: Physical activity in adults with COPD is poor, but behaviour change interventions could help improve activity. This systematic review aims to examine behaviour change interventions to promote physical activity and health outcomes for adults with COPD.
METHODS: Eight databases were searched from inception until April 2023: Web of Science, CENTRAL, MEDLINE, EMBASE, APA PsychINFO, CINAHL, PROSPERO, Cochrane Airways Trials Register. Relevant studies were appraised to determine the impact of behaviour change interventions on physical activity outcomes. Interventions were mapped to Michie's Theoretical Domains Framework (TDF) and a meta-analysis and narrative synthesis conducted. The Cochrane risk of bias tool 2 and the GRADE criteria evaluated bias and the quality and certainty of the evidence.
RESULTS: Twelve randomized controlled trials (RCTs) were included in the review (n = 1211). The most frequently utilized behaviour change interventions included counselling, stepcount monitoring, social support and goal setting. The most commonly measured outcomes across studies were steps-per-day, physical activity levels, exercise capacity and quality of life. A meta-analysis of comparable studies demonstrated there was no difference in stepcount in favour of behaviour change interventions with respect to steps-per-day (SMD 0.16, 95 % CI -0.03, 0.36; p = 0.10). There was some evidence of short-term improvement in physical activity and quality of life, with behaviour change interventions related to goals, behaviour regulation and social influences.
CONCLUSIONS: People with COPD may benefit from behaviour change interventions to increase physical activity and quality of life in the short-term. The overall certainty and quality of the evidence is low.
Osteoarthritis (OA) is a progressive joint disease that can affect all structures that make up the joint, especially cartilage. The frequency of OA increases with age and can especially affect weight-bearing joints such as the knee and hip joints. The main symptoms of knee OA are pain, decreased joint range of motion (ROM), decreased muscle strength, functional loss, and limitation in daily living activities. However, studies conducted in individuals with knee OA report a decrease in quadriceps muscle and knee joint cartilage thickness and impairment in sensorimotor function (proprioception and balance).

Many pharmacological and non-pharmacological methods are used in symptom management of knee OA. In this context, physiotherapy and rehabilitation are among the frequently used non-pharmacological methods. Exercise, manual therapy, taping, aqua therapy, thermal therapy, and electrotherapy are the basic physiotherapy modalities used in OA symptom management. Electrotherapy involves many different agents with different therapeutic purposes. One of these is Neuromuscular Electrical Stimulation (NMES). NMES is a non-invasive method that activates intramuscular nerve branches through surface electrodes placed on skeletal muscles and produces observable contractions. Although its most important therapeutic purpose is muscle stimulation, it also has contributions such as pain relief and sensory stimulation. Superimposed NMES technique (active NMES) is the use of NMES with voluntary muscle contraction. In superimposed NMES with active contraction, the patient is asked to actively contract the relevant muscle during each stimulation. Thus, exercise is performed simultaneously during electrotherapy application. When the literature is examined, there is no study investigating the effect of superimposed NMES with active contraction in patients with knee OA. In this context, the aim of this study is to investigate the effect of superimposed NMES with active contraction on physical function, muscle and joint structure, functionality and quality of life in patients with knee osteoarthritis.
A septal extension graft is frequently applied in esthetic rhinoplasty in Asia. Autologous cartilage is usually selected for the graft material, and nasal septal cartilage is the most commonly used in septal extension grafts. Although the complication rate is reported to be very low, the authors recently encountered a patient who complained of decreased nasal tip projection and stiffness of the nasal tip. The patient had previously undergone a rhinoplasty, including dorsal augmentation with silicone implant and septal extension graft with septal cartilage. Based on the images, the authors hypothesized that the septal extension graft was calcified, and the intraoperative findings confirmed severe calcification of the previously inserted septal cartilage graft. Herein, the authors report the case of a patient with decreased tip projection and stiffness due to calcification of a previous septal extension graft that used septal cartilage and share the lessons the authors learned from this case.
The treatment of skin in neurodermitis comprises simultaneous oral application and cutaneous application of antioxidative vitamins A, C and E or their precursors or derivs. and D-panthenol. USE/ADVANTAGE - The vitamins can be used in the treatment of neurodermitis or atomic eczema. The vitamins are free radical scavengers and act agonistically and synergistically on the radical catching activity of the glutathione peroxidase system of the human body. The oral application increases the efficiency of the cutaneous application in reducing the inflammatory free-radical producing processes and hence the symptoms, such as itching. The oral and cutaneous applications act synergistically.
Diabetics are twice as likely as non-diabetics to develop hypertension. Hypertension is a strong predictor of adverse cerebulo-vascular and cardiovascular events in people with diabetes, which increases risk of Premature micro-vascular and macro-vascular problems in patients encompassing both diseases. Therefore, strict glycemic and blood pressure control is essential to subdue complication and prevent dreadful cardiovascular events such as stroke, Ischemia and myocardial infarction. Participants with both chronic diseases may have lower HRQoL due to increased susceptibility towards cardiovascular comorbidities. Adherence to medication is equally crucial for treatment success. Pharmacist in collaboration with other healthcare members, could play a vital role in the care of patients and optimizing treatment outcomes in patients with chronic diseases .

Chronic disease management is of particular interest to clinical pharmacist since most intervention requires long-term prescription medication use. The international pharmaceutical federation (FIP) and world health organization (WHO) have implored pharmacists to support people with chronic disease through their expanded role that includes "pharmaceutical care." In Nepal, Clinical Pharmacy practice is still in early infancy, though few studies have shown encouraging impacts of pharmaceutical care services. Similarly, there is a significant gap in the literature in this region addressing the impact of pharmacist-supervised educational intervention on both clinical and nonclinical outcomes measures, primarily focusing on co-morbid Diabetes- Hypertensive patients. Therefore, these studies are intended to recap and fill that gap area and add new and valuable insight to the available literature.
Systems, devices, and methods for administering healthcare to a user or patient based on analysis of user-specific respiratory and oximetry parameters is disclosed. Additional parameters specific to the user, the user’s health condition, or the user’s current or planned treatment are optionally included in the analysis. The user inputs parameter values on a healthcare monitoring device. The device communicates such values to a healthcare information hub, which pre-processes the values into data sets and forwards the data sets to a healthcare server. The hub performs preliminary analysis of the parameter values and provides a preliminary report to the user that indicates a characterization of the user’s health condition (e.g., diagnosis, prognosis, suggested preliminary therapy regimen, etc) or whether further parameter values should be input. The healthcare server analyzes the datasets received from the information hub, optionally including additional data sets (e.g., environmental parameters local to the user, demographic data related to the user, the user’s medical history, etc), and infers an instruction for the user. The instruction is relayed to the patient via the information hub and directs the patient to use the monitoring device to obtain further respiratory or oxygenation parameter values, follow a therapy regimen for the user’s health condition, or various partial or complete combinations of both.
A brain tumor and its treatment can affect the visual system at different levels, from the optic nerves (through compression or infiltration). Children with brain tumors can present visual impairments like decreased visual acuity and contrast sensitivity, loss of color vision, and visual field loss such as hemianopias. Patients with hemianopia present difficulties in detecting stimuli in the defective visual field and show defective scanning and exploration. Moreover, they show a rotation and compression of the auditory space leading to imprecise localization of sound across both hemispaces. Patients with hemianopia naturally develop oculomotor strategies to compensate for visual field loss, but visual rehabilitation procedures must still be developed to optimize/improve visual perception in the blind field. Several studies demonstrated that these patients could improve visual perception in the damaged hemifield after a stimulation procedure where auditory and visual stimuli were temporally and spatially correlated. Such audiovisual stimulation programs induce a functional and anatomical reorganization of the visual connectivity in subcortical and cortical structures over time.

The current strategies rely on a significant workload, over 30 hours of audiovisual stimulation using static, spatially, and temporally coherent stimuli displayed on large screens/panels in a clinical setting. These strategies require frequent visits to the clinic impeding the patients' adherence and compliance and increasing the burden of disease. We seek to develop an audiovisual stimulation procedure using immersive virtual reality (IVR) using a head-mounted display (HMD). This is an emerging and very promising visual rehabilitation approach using high-technology devices. It is developed to provide sensory stimulation with better ecological validity due to virtual reality, greater flexibility due to home-based programs, and improved efficiency due to patient-tailored protocols. IVR is a versatile technology, allowing its potential use for the rehabilitation of a variety of low-vision conditions. There are currently limited practical results on whether this technology is suitable for low-vision patients to use at home and if it can be deployed on a large scale. A few case reports/series studies suggested the potential effectiveness of IVR on visual perception in teenagers, adults, and the elderly but more information as to the potential of use and effectiveness of this technology in children and young teenagers is necessary