anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a prospective (observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group), observational (clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions) and cohort study. Study specific information will be collected from participants with chronic renal disease who are receiving recombinant erythropoietin and their treatment course will be followed for up to 2 years and participants will not receive any intervention in this study. Upon entering the study, information will be collected regarding disease history and recombinant erythropoietin treatment. Every 3 months thereafter, progress information will be collected, including recombinant erythropoietin treatment, number of red blood cells and presence of any signs of pure red cell aplasia (PRCA) development. The results of this study will be combined with a similar study (EPO-IMU-402) that also collects blood samples to observe the number of patients who develop antibodies to erythropoietin. Participants discontinuing erythropoietin will be followed only for an additional 12 months from the time erythropoietin is discontinued. Participants will receive standard-of-care treatment for their chronic renal disease from their individual Investigators. Participants will be primarily observed prospectively for PRCA. The study hypothesis is that these data will provide a framework for the expansion of the patient population to estimate the incidence of PRCA associated with the use of epoetin alfa or other recombinant erythropoietins for other therapeutic indications.
The present invention provides a method for producing whole ganoderma lucidum. The mixture of ganoderma lucidum spore powder, ganoderma lucidum powder and carbohydrate is used as culture media, and ganoderma lucidum strains are inoculated after sterilization. After mycelial is full of growth culture media, culture substances are pulverized and dried to obtain a whole ganoderma lucidum product. The present invention preferably solves the problem that the freshness of the spores with broken walls are difficult to keep by utilizing the fact that ganoderma lucidum mycelial continuously secretes ectoenzyme which acts on the walls of ganoderma lucidum spores to make the walls thinned and make films broken until the walls are broken in a growth process and part spore content is converted to mycelium. The product sufficiently reserves the whole effective active constituents of ganoderma lucidum, and is easily absorbed by human bodies. The product has the functions of nutrition, health care and human body immunity enhancement.
Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals. All patients receiving thiazide therapy should be observed for clinical signs of fluid or electrolyte imbalance: hyponatremia, hypochloremic alkalosis, and hypokalemia. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance, irrespective of cause, include: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, confusion, seizures, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting. Hypokalemia may develop, especially with brisk diuresis, when severe cirrhosis is present, or after prolonged therapy. Interference with adequate oral electrolyte intake will also contribute to hypokalemia. Hypokalemia may cause cardiac arrhythmia and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis (e.g., increased ventricular irritability). Although any chloride deficit is generally mild and usually does not require specific treatment except under extraordinary circumstances (as in liver disease or renal disease), chloride replacement may be required in the treatment of metabolic alkalosis. Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt except in rare instances when the hyponatremia is life-threatening. In actual salt depletion, appropriate replacement is the therapy of choice.
Systemic exposure of adapalene following topical application of adapalene gel was evaluated in a clinical trial. Sixteen acne subjects were treated once daily for 10 days with 2 grams of adapalene gel applied to the face, chest and back, corresponding to approximately 2 mg/cm2. Fifteen subjects had quantifiable (LOQ = 0.1 ng/mL) adapalene levels resulting in a mean Cmax of 0.553 ± 0.466 ng/mL on Day 10 of treatment. The mean AUC0-24hr was 8.37 ± 8.46 ng.h/mL as determined in 15 of the 16 subjects on Day 10. The terminal apparent half-life, determined in 15 of 16 subjects, ranged from 7 to 51 hours, with a mean of 17.2 ± 10.2 hours. Adapalene was rapidly cleared from plasma and was not detected 72 hours after the last application for all but one subject. Exposure of potential circulating metabolites of adapalene was not measured. Excretion of adapalene appears to be primarily by the biliary route.

In another clinical trial in subjects with moderate to moderately severe acne, adapalene gel, 0.3% or Adapalene Gel, 0.1% was applied to the face and optionally to the trunk, once daily for 12 weeks. Seventy-eight (78) subjects had plasma adapalene levels evaluated at Weeks 2, 8, and 12. Of the 209 plasma samples analyzed, adapalene concentrations were below the limit of detection (LOD = 0.15 ng/mL) of the method in all samples but three. For the three samples, traces of adapalene below the limit of quantification (LOQ = 0.25 ng/mL) of the method were found. One of these samples was taken at Week 12 from a male subject treated with adapalene gel who treated the face and the trunk for eight weeks (thereafter, only the face was treated). The second and third samples were from the Week 2 and 12 visits of a female subject treated with adapalene gel, 0.1% who treated only the face for 12 weeks. In this study, the average daily usage of product was 1 g/day.
Experimental group will receive education on diabetes and conventional treatment exercises. The interventional multisystem exercises program will consist of four components, with each exercise lasting for a duration of 10 minutes per session. These components encompass proprioception training, balance exercises, strengthening routines, and reaction time training. This total multisystem exercises session will be performed for 30 minute, 3 times a week for 8 weeks in total.
OBJECTIVES: Observational studies have linked rheumatoid arthritis and frailty, but confounding factors and reverse causality make it unclear if there is a causal relationship. The current study used bidirectional two-sample Mendelian randomisation (MR) to assess the bidirectional causation between rheumatoid arthritis and frailty.
METHODS: The primary analysis used the latest GWAS data for rheumatoid arthritis and frailty index in pure Europeans from large genome-wide association studies. Validation analysis was done to verify the accuracy of the results. The appropriate instrumental variables (IVs) were selected based on the three MR assumptions. The MR methods used were MR-Egger, weighted median (WM), and inverse variance weighted (IVW). The effects of horizontal pleiotropy were examined using the MR-Egger intercept and the MR-PRESSO method. To avoid single SNP bias, a leave-one-out analysis was performed.
RESULTS: Genetic predictions suggested that there is a significant association between rheumatoid arthritis and the increased prevalence of frailty (IVW OR=1.01; 95% CI=[1.01-1.02], p=2.47 E-06). It has been verified in validation analysis that rheumatoid arthritis is also associated with frailty (IVW OR=1.03, 95% CI=[1.02-1.04], p=3.30E-17). Notably, genetic predictions suggested that frailty may be associated with the onset or development of rheumatoid arthritis (IVW β=1.25, SE=0.44, 95% CI=[0.39-2.12], p=4.58E-03).
CONCLUSIONS: The present study provides evidence supporting the fact that rheumatoid arthritis can increase the prevalence of frailty. Frailty may be a risk factor for rheumatoid arthritis, and whether frailty is involved in triggering the onset or progression of rheumatoid arthritis needs further study.
PURPOSE:To maintain an antimicrobial effect without degrading. during long- term preservation and even if the band is immersed in water during use by holding gauge consisting of fibers contg. zeolite deposited with a metal having the antimicrobial effect by an ion exchange onto a sheet-like base material having a tacky adhesive surface. CONSTITUTION:The resilient sheet-like base material 10 consisting of a synthetic resin has the tacky adhesive layer 12 on one surface and is stuck with the antimicrobial gauge 14 in its central part. The antimicrobial gauge 14 consists of the fibers contg. the zeolite deposited with the metal having the antimicrobial effect by the ion exchange. The above mentioned zeolite is exemplified by A type zeolite, X type zeolite, Y type zeolite, mordenite, etc. The zeolite having the largest possible specific surface area among these materials is more preferable. While one or >=2 kinds among copper, silver and zinc are usable as the metal having the antimicrobial effect, the silver is most preferable.
This group of researchers previously observed that lupus patients with an elevated interferon alpha signal produced less neutralizing antibody to influenza vaccine which was directly or indirectly associated with increased flares and autoantibody production after immunization. Anifrolumab is an inhibitor of signaling through the Type I interferon alpha beta receptor. The current study is an open label parallel group pilot study to examine the impact of anifrolumab on development of neutralizing antibodies to quadrivalent influenza vaccine in patients with SLE. 10 patients with moderately to severely active SLE will initiate treatment with anifrolumab while continuing standard of care medications and 10 will receive only standard of care medications. Two weeks after baseline all will receive influenza vaccine. Blood samples will be drawn at baseline (Day 0), just prior to immunization (Week 2), and Weeks 4, 8, 12 and 16. Disease activity, gene/cytokine expression, autoantibody production and patient reported outcomes will also be tracked.
The inventor personally brought people to a location discovering vaccine virus to collect vaccine virus samples and returned to a Jiang-Po-Kun vaccine virus culture (cultivation) room to culture (cultivate) the vaccine virus. Some chemical substances were added into the vaccine virus to produce a chemical change to be changed to all vaccines of this invention. These vaccines are sold in 196 regions (countries) worldwide, and Rangwei is the new name of the vaccines worldwide. The vaccines will produce antibodies in animals, such that the animals will not be infected after vaccination, that is, will not be infected by viruses and catch the disease. The temperature of the culture (cultivation) room is the same as the temperature of nature. The temperature that the vaccine virus and the vaccine can survive is the temperature of the culture (cultivation) room. The principle of action of the vaccine virus plus the chemical substances is to be vaccinated to produce the antibodies without being infected by the viruses, so as to control the mutation of the virus. The same principle is applied for adding chemical substances into the mutated viruses. What are chemical substances. Any substance can produce chemical effects, and the viruses are one of them.
We overfed 40 young, healthy adults by 40% of their baseline energy requirements for 8 weeks. The diet consisted of 41% carbohydrate, 44% fat, and 15% protein.
A prospective, randomized, double-blind study conducted in the complementary examination department of the Luxembourg Hospital, approved by the ethics and research committee of the Luxembourg Hospital / Mário Penna Foundation (CAAE: 56538616.2.3001.5121). The sample size was calculated in 21 participants for each group, based on a previous study, considering a standard deviation of 7.5, to detect a difference of 7.5 minutes, with a power of 90% and significance level of 5% . To cover possible losses, two groups were set up with 25 participants: midazolam and propofol, B fentanyl and propofol. Patients were invited to participate in physical status ASA I and II candidates for elective colonoscopy.

The randomization was done through the distribution of numbers generated by the site www.random.org in two groups A and B, with a sweeping draw. All participants signed a free and informed consent form. The syringes were previously prepared by the anesthesiology resident with 3mg midazolam or 50 mcg fentanyl and double distilled water to make up to 5ml volume. Patients received standard and oxygen monitoring by nasal catheter at 4 liters / minute. The anesthesiologist in charge administered a syringe delivered by the resident according to the randomization, without knowing which solution was followed, followed by 50 mg of propofol in increments of 20 mg until reaching the Ramsay stage 4 of sedation and then the physician endoscopist was authorized to introduce the colonoscope. The patient was maintained in this sedation plan until the device was withdrawn through further 20 mg increments of propofol administered according to the subjective evaluation of the anesthesiologist. Episodes of patient awakening, movement, oxygen saturation (SpO2) drop below 90%, and need for ventilatory assistance were noted if they occurred. The time between the introduction of the endoscope and its withdrawal was defined as the examination time.Then, the patient was refered to the post-anaesthesia care unit 1(PACU 1) where remained monitorized and supervised by a nurse technique and a doctor from anestehsiology team until reached the Aldrete Recovery Scale nine score. Reaching this criterion, the patient was referred to post-anaesthesia care unit 2 (PACU 2) where he remained seated, without monitoring and supplemental oxygen until he was able to walk,and drink water. Then he was discharged from the hospital. This time was noted by another nursing technique: SRPA 2 Time. Quantitative variables were submitted to the Shapiro-Wilk normality test, which is more suitable for small samples. Data that presented normal distribution (parametric data) were submitted to Student's t-Test. Non-parametric data were analyzed according to the Wilcoxon Test. The Pearson Correlation Tests (parametric data) and Spearman (nonparametric data) were used to evaluate the existence of a relationship (positive or negative) between two variables. In all tests, the obtained differences were considered statistically significant when the value of p was less than 0.05 (p \<0.05). The analyzes were performed using GraphpadPrism®, version 5.0 for Windows.
The invention relates to the field of psychopharmacology. More particularly, the invention relates to the treatment of mental disorders, such as impaired interpersonal and behavioral disorders, including sexual disorders such as M.E.D. and H.S.D.D. The invention provides new therapeutic compositions and methods for treating mental disorders, including M.E.D. and H.S.D.D. The compositions and methods according to the invention provide improved awareness and alertness to environment, improved adaptation to environment and ability to sustain attention, and increased interest in environment and capacity for arousal, without increased aggressiveness.
The invention relates to a heat clearing and detoxifying Trapa incisa var. sieb. liquor and a preparation method thereof. The heat clearing and detoxifying Trapa incisa var. sieb. liquor is prepared from, by weight, 25-35 parts of Trapa incisa var. sieb., 15-25 parts of Tetracera asiatica, 15-25 parts of Herba Patriniae, 15-25 parts of Herba Polygalae Japonicae, 10-15 parts of Euphorbia hypericifolia, 10-15 parts of Indigofera tinctoria Linn, 10-15 parts of Flos Hibisci, 5-10 parts of Rhizoma Pinelliae, 5-10 parts of Semiliquidambar cathayensis, 5-10 parts of Avicennia Pricklyash Root and 1500-2000 parts of grain liquor. The preparation method concretely comprises the following steps: 1, preprocessing of raw materials; 2, immersion; and 3, decocting, and mixing. The heat clearing and detoxifying Trapa incisa var. sieb. liquor obtained by pure grain liquor immersion has no damages to the health of human bodies, and can be drunk for a long term to realize the efficacy of clearing heat and detoxifying, invigorating the spleen and strengthening the stomach, and promoting the production of body fluid to quench thirst.
PROBLEM TO BE SOLVED: To obtain the subject food indispensably containing an extract of a plant belonging to the genus of Murraya, capable of simply preventing and removing a bad breath by daily oral ingestion, extremely high in safety to the human body, and capable of ingesting even to an infant without a fear. SOLUTION: This food for preventing and removing a bad breath indispensably contains an extract of a plant belonging to the genus of Murraya. As the plant belonging to the genus of Murraya, Murraya paniculata Jack or Murraya koenigii Spreng are preferable. Also, the leaves of the plant belonging to the genus of Murraya are preferably used as a starting material. For the extraction, a polar solvent such as water, methanol is preferably used for their high extracting efficiency. Isomahanine of formula I, murrayanol of formula II and/or mahanine of formula III are also preferably blended as active ingredients. Further, since mercaptans produced by microorganisms in an oral cavity can not completely be removed by the above extract, extracts of a tea, a rosemary, etc., can preferably be blended as sub-components.
Disclosed is a use of a basella alba extract for preparing a composition for preventing or treating nervous system diseases. The basella alba extract is derived from the basella plant, and contains polysaccharides. The nervous system diseases include neurodegenerative diseases and cell cycle abnormalities. The neurodegenerative disease includes dementia or movement disorders. The dementia includes Alzheimer's disease, vascular dementia, frontotemporal lobe dementia, dementia with Lewys body, or mild cognitive impairment. The movement disorders include Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, cerebellar atrophy or multiple system atrophy. The cell cycle abnormality of the nervous system cell is a nervous system tumor.
OBJECTIVES: Low back pain is an important public health problem that impairs quality of life and causes limitations in both social and working life. It is attempted to be treated with conservative or surgical procedures. However, how wise is it to plan surgery with a high complication rate when conservative treatment fails to respond?
METHODS: In this study, it was planned to investigate the effectiveness of the Disc-Fx procedure, which is one of the minimally invasive techniques for low back pain. Patients who underwent the Disc-Fx procedure were included. After consent was obtained, questions were asked before and after the procedure. The data of the patients were obtained by telephone and hospital database. Data of 40 patients older than 18 years of age were collected and analyzed retrospectively according to the established protocol. Then, the data were subjected to statistical calculation and the results were obtained.
RESULTS: Similar to the literature, there was a significant difference between preoperative and postoperative 1st, 6th, and 12th months of VAS, ODI, and MacNab values. In fact, a significant difference was found between the VAS, ODI, and MacNab values in each postoperative period compared to the preoperative period. In addition, factors that may be important in the etiology of low back pain were also evaluated.
CONCLUSION: The Disc-Fx procedure is thought to be a promising procedure for carefully selected patients due to its low complication rates. It has been concluded that more precise results can be obtained as a result of randomized controlled studies with a larger number of patients and longer follow-up of patients.
Participants received a combination of PEG-IFN alfa-2b plus RBV according to routine clinical practice and locally-approved product recommendations for a minimum of 12 weeks. No investigational medicinal product was provided by the sponsor.
Onium salts of taxo-diterpenoid-Cn, 2-0-aza-arenes are employed as water soluble prodrugs. For example, taxol-2'-methylpyridinium tosylate (MPT) is characterized by an elevated aqueous solubility, rapid activation by serum protein, good stability in most other aqueous solutions, formation of a protein:taxol intermediate and good retension within the circulatory system.  The toxicity of the activated form is comparable or greater than underivatized taxol. Furthermore, taxol-2'-MPT can be synthesized by a simple one step reaction between taxol and 2-fluoro-1-MPT. The invention is applicable to taxol and taxol mimetics having hydroxyls that are reactive with onium salts of 2-halogenated-aza-arenes. For example, taxol, C-2 substituted analogs of taxol, and Taxotere each have reactive hydroxyls at the 2' and 7 positions.  The invention is also applicable to a wide array of 2-halogenated-aza-arenes.
Acute phlegmonous esophagitis (APE) is a rare disease caused by bacterial infection of the oesophagus, typically involving the submucosal and muscularis layers. Patients may present with chest pain, dysphagia, odynophagia, dyspnoea, fever, nausea and vomiting, making diagnosis difficult. We present two cases of APE, both young females who presented with dysphagia and odynophagia. The first patient had a history of surgery (left mastoidectomy) which might have functioned as a nidus for infection, whereas the second patient had uncontrolled diabetes. CT findings in both patients revealed diffuse oesophageal thickening, and oesophagogastroduodenoscopy showed erythema and ulcerations. Both patients were managed conservatively using intravenous antibiotics and supportive therapy. APE is associated with a high mortality rate and warrants early diagnosis and treatment. CT is the preferred non-invasive diagnostic modality. Treatment includes systemic antibiotics, nutritional support and timely endoscopic or surgical intervention. Invasive intervention is indicated in patients not responding to medical therapy or in those with complications.
The invention discloses an isolating film of hygroscopicity and self-adhesion which is used for preventing postoperative synechia. The isolating film is characterized by comprising 65 percent to 99 percent of carboxylation chitosan, 1 percent to 10 percent of glycerin, 0 percent to 5 percent of citric acid, and the rest being water. The preparing steps are as follows: weighing the ingredients by weight percentage; adding the carboxylation chitosan into water and stirring for thorough dissolution; adding the other ingredients into the solution and stirring; pouring the mixed solution into a glass mold for self-leveling, drying the solution for forming film and then cooling to room temperature; and at last, stripping the film from the mold. The isolating film is bacteria-free; when being implanted in human bodies, the film immediately absorbs tissue fluid once in contact with surface of wound, thus having viscidity. The isolating film which is simple and convenient in clinic can be automatically adhered on surface of wound which needs isolating. Therefore, the isolating film has the efficacy of promoting wound healing and preventing tissues from adhesion.
In this 2-year pilot study, we plan to screen family caregivers of lung cancer patients within 4 to 6 weeks after the a new visit to the thoracic clinic. We will screen spouses, adult children, and other family members using the HAD-18 to determine their level of anxiety and depressive symptoms at enrollment.