anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
555,044. Treating silk prior to pulverizing. PHELPS, S. G. Jan. 28, 1942, No. 1205. [Class 59] [Also in Groups VI and IV] In the preparation of powdered silk for use as a cosmetic and for application in ointments &c. the material is first boiled in a weak solution of lauryl sulphate, washed with cold water, heated slowly with dilute sulphuric acid, borax is then added, the mixture allowed to cool and liquid drained off, fresh water added to the silk and boric acid and brought to the boil. The liquid is strained from the silk which is dried at 85 ‹F. and pulverized.
BACKGROUND: To reduce the risk of viral transmission, guidelines recommend the use of designated haemodialysis machines and patient isolation for patients with chronic hepatitis B virus (HBV). These practices are without a strong evidence base, and may no longer be necessary in the setting of heat disinfection programs and standard precautions.
METHODS: An online cross-sectional survey was developed for renal clinicians across Australia and New Zealand to explore infection prevention policy concerning patients with chronic HBV in haemodialysis units. We sought to determine whether psychosocial and cultural impacts might result from the mandatory use of machine designation and patient isolation practices, as perceived by multidisciplinary healthcare workers with experience working with this patient population.
RESULTS: Sixty-seven responses from 27 health districts across all states of Australia and one New Zealand district were received. Most respondents were from urban areas (65%), and were nurses (87%). 50% of health districts reported using designated machines, while 32% isolate patients. Lack of necessary resources limited the use of designated machines (57%), and patient isolation (78%). Respondents not routinely using these precautions were more likely to express concerns regarding patient psychosocial wellbeing and cultural appropriateness. Overall, 30% of respondents expressed concerns regarding the cultural appropriateness of these recommendations.
CONCLUSION: We demonstrate wide variation in haemodialysis infection prevention and control policy and practice with regards to managing patients with chronic HBV. While use of standard precautions and machine disinfection are consistently applied, resource availability and concerns for patient psychosocial wellbeing limit adherence to international guidelines.
PURPOSE: A makeup cosmetic composition containing a cholesteric liquid crystal containing a useful pigment is provided to implement an optical property such as hologram when applied on skin or lip. CONSTITUTION: A makeup cosmetic composition contains 50.0-99.999 wt% of a cholesteric liquid crystal containing a useful pigment. The composition contains 0.001-10.0 wt% of the useful pigment. The cholesteric liquid crystal is a liquid crystal mixture containing a nematic liquid crystal(NLC) with chiral dopant which induces a periodic helical structure. The cholesteric liquid crystal selectively reflects light according to the pitch of a repetitive structure and the twisting direction of the helix. [Reference numerals] (AA) Optical characteristic from external appearances; (BB) Optical characteristic after being applied on lips; (CC) Comparative example 1; (DD) Comparative example 2; (EE) Comparative example 3; (FF) Example 1; (GG) Example 2
Pigmented formed wax articles for use in applying a layer of pigmented wax material to a surface by rubbing said article thereon, for example lipsticks and other wax-base cosmetics, comprise a crystalline wax component formed into the form of said article, and a solid pigment phase of discrete particles uniformly dispersed through said molded wax component and forming therewith a self-sustaining matrix of enhanced strength and crush resistance for said article, at least part of said dispersed pigment particles carrying on the surfaces thereof a water-insoluble oleophilic material in an amount of 5-25% by weight based on the weight of the pigment.  The wax base may be derived from beeswax, lanolin, spermaceti, candelilla, carnauba, paraffin, or petroleum crystalline or microcrystalline wax, which may be blended with a liquid material such as castor oil, liquid lanolin, liquid petrolatum or a liquid fatty acid ester.  As the oleophilic material there is generally used a water-insoluble metal salt of a fatty acid, preferably one which has an alkaline pH. The oleophilic material may also include an acid dye which develops colour at the alkaline pH of the preferred fatty acid salts, e.g. tetrabromofluorescein dye.  The pigment can comprise both white and coloured compounds, with the former being the major component.  In such mixed pigments, only the white component need be treated with the oleophilic material.  White pigments specified are titanium dioxide, blanc fixe, zinc oxide, whiting, lead pigments, lithopone, chalk, barytes, talc, kaolin and silica.
Long COVID is a poorly understood condition characterized by persistent symptoms following the acute phase of COVID-19, including fatigue, cognitive impairment, and joint pain. Acupuncture, a key component of traditional Chinese medicine treatment, has shown potential in alleviating long COVID symptoms. However, the molecular mechanisms underlying its therapeutic effects remain largely unknown. In this study, we employed bioinformatics approaches to explore the potential molecular mechanisms of acupuncture's therapeutic effects on long COVID symptoms. We screened protein targets of active ingredients produced by the body after acupuncture and identified potential therapeutic targets of long COVID. Protein-protein interaction networks were constructed, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify key targets and pathways. Our findings provide valuable insights into the potential molecular mechanisms of acupuncture's therapeutic effects on long COVID symptoms and may contribute to the development of targeted therapies for managing this challenging condition.
BACKGROUND: Catch-up growth issues among children born small for gestational age (SGA) present a substantial public health challenge. Prenatal exposure to heavy metals can cause adverse effects on birth weight. However, comprehensive studies on the accurate assessment of individual blood concentrations of heavy metals and their effect on the failure to achieve catch-up growth remain unavailable. This study aimed to evaluate the effects of uterine exposure to toxic metals cadmium, lead, and mercury and essential trace metals manganese and selenium at low concentrations on the postnatal growth of children born SGA.
METHODS: Data on newborn birth size and other factors were obtained from the medical record transcripts and self-administered questionnaires of participants in the Japan Environment and Children's Study. The blood concentrations of lead, cadmium, mercury, selenium, and manganese in pregnant women in their second or third trimester were determined by inductively coupled plasma mass spectrometry. These heavy metal concentrations were also assessed in pregnant women's cord blood. Furthermore, the relationship between each heavy metal and height measure/catch-up growth in SGA children aged 4 years was analyzed using linear and logistic regression methods. These models were adjusted for confounders.
RESULTS: We studied 4683 mother-child pairings from 103,060 pregnancies included in the Japan Environment and Children's Study. Of these, 278 pairs were also analyzed using cord blood. At 3 and 4 years old, 10.7% and 9.0% of children who were born below the 10th percentile of body weight had height standard deviation scores (SDSs) below 2, respectively. Cord blood cadmium concentrations were associated with the inability to catch up in growth by 3 or 4 years old and the height SDS at 3 years old. In maternal blood, only manganese was positively associated with the height SDS of SGA children aged 2 years; however, it was not significantly associated with catch-up growth in these children.
CONCLUSION: Cadmium exposure is associated with failed catch-up development in SGA children. These new findings could help identify children highly at risk of failing to catch up in growth, and could motivate the elimination of heavy metal (especially cadmium) pollution to improve SGA children's growth.
Treatment should include general supportive care, atropinization, and decontamination, in addition to the use of PROTOPAM Chloride. Treatment is most effective if initiated immediately after poisoning. Administration of PROTOPAM Chloride should be carried out slowly and, preferably, by infusion. If intravenous administration is not feasible, intramuscular or subcutaneous injection should be used. Generally, little is accomplished if PROTOPAM Chloride is given more than 36 hours after termination of exposure to the poison. When the poison has been ingested, it is particularly important to take into account the likelihood of continuing absorption from the lower bowel since this constitutes new exposure and fatal relapses have been reported after initial improvement. In such cases, additional doses of PROTOPAM Chloride may be needed every three to eight hours. In effect, the patient should be “titrated” with PROTOPAM Chloride as long as signs of poisoning recur. As in all cases of organophosphate poisoning, care should be taken to keep the patient under observation for at least 48 to 72 hours.

If dermal exposure has occurred, clothing should be removed and the hair and skin washed thoroughly with sodium bicarbonate or alcohol as soon as possible. 

Supportive care, including airway management, respiratory and cardiovascular support, correction of metabolic abnormalities, and seizure control, may be necessary in cases of severe organophosphate poisoning.

Atropine should be given as soon as possible after hypoxemia is improved. Atropine should not be given in the presence of significant hypoxia due to the risk of atropine-induced ventricular fibrillation. In adults, atropine may be given intravenously in doses of 2 to 4 mg. This should be repeated at 5- to 10-minute intervals until full atropinization (secretions are inhibited) or signs of atropine toxicity appear (delirium, hyperthermia, muscle twitching).

Some degree of atropinization should be maintained for at least 48 hours, and until any depressed blood cholinesterase activity is reversed.

Use of morphine, theophylline, aminophylline, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with organophosphate poisoning (see PRECAUTIONS, Drug Interactions). Prolonged paralysis has been reported in patients when succinylcholine is given with drugs having anticholinesterase activity; therefore, it should be used with caution.

After the effects of atropine become apparent, PROTOPAM Chloride may be administered.
PURPOSE OF THE REVIEW: Macrophage accumulation and activation function as hallmarks of atherosclerosis and have complex and intricate dynamics throughout all components and stages of atherosclerotic plaques. In this review, we focus on the regulatory roles and underlying mechanisms of macrophage phenotypes and metabolism in atherosclerosis. We highlight the diverse range of macrophage phenotypes present in atherosclerosis and their potential roles in progression and regression of atherosclerotic plaque. Furthermore, we discuss the challenges and opportunities in developing therapeutic strategies for preventing and treating atherosclerotic cardiovascular disease.
RECENT FINDINGS: Dysregulation of macrophage polarization between the proinflammatory M1 and anti-inflammatory M2 phenotypealters the immuno-inflammatory response during atherosclerosis progression, leading to plaque initiation, growth, and ultimately rupture. Altered metabolism of macrophage is a key feature for their function and the subsequent progression of atherosclerotic cardiovascular disease. The immunometabolism of macrophage has been implicated to macrophage activation and metabolic rewiring of macrophages within atherosclerotic lesions, thereby shifting altered macrophage immune-effector and tissue-reparative function. Targeting macrophage phenotypes and metabolism are potential therapeutic strategies in the prevention and treatment of atherosclerosis and atherosclerotic cardiovascular diseases. Understanding the precise function and metabolism of specific macrophage subsets and their contributions to the composition and growth of atherosclerotic plaques could reveal novel strategies to delay or halt development of atherosclerotic cardiovascular diseases and their associated pathophysiological consequences. Identifying biological stimuli capable of modulating macrophage phenotypes and metabolism may lead to the development of innovative therapeutic approaches for treating patients with atherosclerosis and coronary artery diseases.
Admission NTproBNP levels will be used to stratify participants into lower and medium-higher risk care pathways. NTproBNP levels will be repeated on Day 2-3 and again prior to discharge. Each care pathway is designed to optimize discharge time according to NTproBNP levels. All NTproBNP results will be displayed on the front of the participant's chart along with the care pathway that the participant has been randomized to. The care providers will be reminded daily by the study team that the participant is in the biomarker guided discharge pathway arm of the study and that the designated care pathway should be followed as closely as possible.
The serum is obtd. by injecting an animal, pref. a horse, over 6-8 weeks with lymphocytary prepns obtd. by mixing >=5 pref. >10 strains of permanent lymphoblastoid cultures from human subjects and 10-20 days after the final injection, recovering the serum from the blood. The serum is useful in transplant, treatment of autoimmune diseases, certain neurological disorders and certain inflammations. In an example, human leucocytes were cultured conventionally and after the establishment of permanent lines, nine such lines were mixed, injected subcutaneously into a horse in six weekly injections of 5 x 109 rising to 3 x 1010 cells. The serum was recovered 10 days after the last injection.
All patients receive Tetanus-Diphtheria booster vaccine at time of enrollment. Cycles of standard TMZ (150-200 mg/m\^2/day on days 1-5 of each 28 day cycle) with PEP-CMV vaccination on Day 23 (-1 day, + 2 days) of each TMZ cycle and tetanus pre-conditioning the day before the first vaccine. Vaccine components A and B were administered separately, with a delay between them, to determine if it was an individual component or a combination of the components that resulted in adverse reactions.
A method of colon cleansing that provides superior cleansing. In an embodiment, superior cleansing of the right colon is provided. In an embodiment, a stimulant laxative is consumed at least two days prior to the day for which maximum cleansing is desired, and an osmotic purgative is consumed one day prior to the day for which maximum cleansing is desired. A  regimen that administered PICO- SALAX® plus BISACODYL.TM. was superior in cleansing the right colon compared to PICO-SALAX® alone, and when compared to Oral Sodium Phosphate. Patient tolerability and safety were excellent.
<P>PROBLEM TO BE SOLVED: To improve an additive-free method for aging a deodorized garlic and to make administration of a purified extract safe.  <P>SOLUTION: A method for production is composed as follows. An additive-free garlic pressed stock solution 5 in an aging step 1 is subjected to repeated both operations of stirring and precipitating and stored for at least one year. After a still standing period for definitely separating floating substances and precipitates at the end of aging, a liquid concentrate 7 is collected and then heated in a water bath in a dehydrating step 3 while being stirred. A dehydrated granulated material 8 is then provided or powdered or granulated in a post-treating step 4 for further drying. Acclimatization of a stimulating component is intended without adding a substance other than the raw garlic. A processed material such as an extract liquid 16, the granulated material 8 or powder obtained in each step is directly used in the collected state or mutually mixed and prepared or mixed with other kinds of raw materials to provide an auxiliary raw material 13 or selectively processed as a solvent 17, etc. An extract liquid, etc., retaining a fermentative component are added to compose a preparation controlling a fermentation reaction or an extract purified processed product (solid/liquid) converting a dentifrice into a product such as a composite functional product including washing of periodontal sites and the oral cavity.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
OBJECTIVE: To investigate the clinical efficacy of artificial cervical disc replacement for cervical disc herniation.
METHODS: Retrospective analysis of 24 patients with cervical disc herniation with 24 segments admitted from July 2016 to July 2022, including 12 males and 12 females, with an average age of (50±2) years old ranging from 36 to 68 years old. The intervertebral space height of the lesion segment before replacement was 4.3 to 7.2 mm with an average of (5.6±1.6) mm, the range of motion of anterior flexion and posterior extension was 5.6° to 7.2° with an average of (6.4±1.3)°, the range of motion for the left and right lateral flexion was 10.2° to 11.4° with an average of (10.7±1.8)°, and the Japanese Orthopaedic Association (JOA) score was 8 to 13 scores with an average of (8.0±0.3) scores. Through anterior incision, artificial cervical disc replacement surgery was performed after cervical discectomy and decompression.
RESULTS: After surgery, all patients'incisions healed well. All patients were followed up from 12 to 60 months with an average of (33±12) months. At the final follow-up, the intervertebral space height of replacement segment was 4.0 to 6.8 mm with an average of (5.4±1.3) mm, the range of motion of anterior flexion and posterior extension was 4.6° to 6.4°with an average of (5.6±1.2)°, the range of motion of left and right lateral flexion was 8.7°to 10.3°with an average of (9.5±1.5)°. The prosthesis did not shift or sink, slight heterotopic ossification occurred within the operative segment(ⅠorⅡgrade). The height of adjacent intervertebral spaces was not lost, there was no vertebral degeneration, no significant change in the comparison of adjacent segment mobility before and after surgery. The JOA score increased from (8.0±0.3) scores before replacement operation to (15.0±0.2) scores after operation.
CONCLUSION: Artificial cervical disc replacement surgery can not only obtain the same efficacy as the anterior cervical disc fusion surgery, but also avoid the increase of compensatory stress of adjacent segments, maintain the stability of the biomechanical environment, thereby reducing the incidence of degeneration of adjacent segments, and can be used as an effective method for the treatment of cervical disc herniation, , but the long-term efficacy and the existing problems of replacement surgery need to be further studied and solved in the future.
<P>PROBLEM TO BE SOLVED: To provide a medical mistake preventing system and a composite photographing device for preparing a chart photograph.  <P>SOLUTION: In the medical mistake preventing system, the entry fields of a reception card are provided with a patient's attribute information description field including the data of birth, sex, and the name of a patient. Prescribed items with an autograph by the patient or a person interested are described in the description field. The composite photographing device automatically collates the patient's attribute information with the reception card with the contents of the reception card confirming or collates the patient's attribute information previously memorized by a receptionist with the reception card. After confirming agreement, the reception card is photographed. In addition, a photographic camera is moved to an appropriate location for adjustment to photograph the face photograph of the patient. The appropriate sheets of the sealed chart photographs integrating the patient's attribute information on the reception card with the face photograph are printed on a sheet of paper. The chart photographs are stuck on a medical information means requiring personal confirmation.  <P>COPYRIGHT: (C)2003,JPO
Postoperative pain impedes the progress of recovery and increases the risk of postoperative complications, namely lung atelectasis, incidence of desaturation, pulmonary dysfunction and chronic pain. Although opioid is the one of the gold standard analgesia for postoperative pain, it comes with many unwanted adverse effects, such as respiratory depression, hypotension and incidence of nausea and vomiting. Thus, multimodal analgesia regime, including local anaesthetic is strongly advocated for postoperative analgesia.

Lignocaine is a local anaesthetic agent, which has the properties of analgesia, anti-inflammatory and anti-arrhythmia effect via the blockade of sodium channel receptor in the spinal cord and dorsal root ganglia. The intravenous lignocaine exerts its effect via the systemic absorption of drugs to block the central neuronal transmission. In recent years, studies have demonstrated that intraperitoneal route of lignocaine can reduce visceral pain by inhibiting peritoneal free nerve ending and reduce peripheral neuronal hyper-excitatory of pain signal transmission. It is also believed that intraperitoneal lignocaine is associated with minimal systemic absorption of drug and lower incidence of systemic toxicity local anaesthesia as compared to the intravenous route of lignocaine.

Several randomised controlled trials (RCTs) showed the beneficial effect of intraperitoneal lignocaine for the reduction of postoperative visceral pain after laparoscopic surgery. However, gynaecological open surgery has greater degree of organ manipulation and tissue injury with greater visceral pain, resulting in longer duration of hospitalisation and delayed functional mobility recovery. It is believed that the intraperitoneal lignocaine reduces inflammatory response after surgery and exert analgesia effect by blocking the neural pain signal transmission at site of tissue injury. The dosage of intraperitoneal lignocaine used in the literature ranged from 200-400mg. The serum concentration of intraperitoneal lignocaine was measured, which was associated with a relatively safe serum concentration of lignocaine. Pharmacological studies have showed that the adjuvant dose of adrenaline reduced the systematic absorption of intraperitoneal lignocaine. Therefore, this study is designed to examine the analgesic effect of intraperitoneal lignocaine in gynaecological open surgery. The investigators hypothesised that intraperitoneal lignocaine reduces postoperative pain score at rest and movement in women undergoing gynaecological open surgery.
The present invention provides pulsed cyclic administration regimes and pulsed administration regimes for interleukin-2/interleukin-15 receptor ?? (IL-2/IL-15R??) agonists for treating or managing cancer or infectious diseases in human patients. The administration regimes inter alia involve daily administration of IL-2/IL-15R?? agonists on 2, 3 or 4 consecutive days followed by days without administration.