anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Background: Various inotropes and inodilators have been utilized to treat low cardiac output syndrome after the arterial switch operation. The use of levosimendan, a calcium sensitizer has been limited in this setting. This study compares the effects of levosimendan with milrinone in managing low cardiac output after the arterial switch operation. Methods: A retrospective, comparative study was conducted in a tertiary care hospital on patients weighing up to 3 kg undergoing the arterial switch operation between January 2017 and January 2022. Patients received a loading dose followed by continuous infusion of either levosimendan or milrinone. Echocardiographic, hemodynamic and biochemical parameters were compared. Results: Forty-three patients received levosimendan and 42 patients received milrinone as the primary test drug. Cardiac index of less than 2.2 L/min/m2 on postoperative day 1 and 2 was found in 9.3% and 2.3% of patients receiving levosimendan versus 26.2% and 11.9% in those receiving milrinone, respectively (P = .04 and .08, respectively). Early lactate-clearance and better central venous oxygen saturations were noted in the levosimendan group. Prevalence of acute kidney injury was higher in the milrinone group (50% vs 28%; P = .03). Use of peritoneal dialysis in the milrinone group versus levosimendan was 31% and 16.3%, respectively (P = .11). There was no difference in hospital mortality between the groups (milrinone, 3; levosimendan, 2, P = .62). Conclusions: Levosimendan is safe and as effective as milrinone to treat low cardiac output syndrome occurring in neonates after the arterial switch operation. In addition we found that levosimendan was renal protective when compared with milrinone.
The present invention relates to a novel donkey-hide gelatin preparation and a preparation method thereof. The method of the present invention comprises the specific steps: shells, oxhorn, pearl, oyster shells, caladium and donkey-hide gelatin are fried together, frying and stop are preferably carried out alternately, namely that after the mixture is dried for a period of time, the mixture leaves fire and frying stops for a period of time until the mixture is fried when the donkey-hide gelatin is completely foamed, and the donkey-hide gelatin is recovered. Other ingredients can be used for continuously frying the donkey-hide gelatin or be used as raw materials of traditional Chinese medicine. The fried donkey-hide gelatin is brown, and the external shape is like an egg, the inner part is in the shape of a honeycomb, and small cells are distributed fully. The donkey-hide gelatin well fried can be directly packaged to become a product, or the donkey-hide gelatin can be further ground into fine powder and is encapsulated to make a capsule, or the donkey-hide gelatin is bagged to make powder. The donkey-hide gelatin preparation of the present invention has the advantages of convenient use and adaption to storage and carrying.
Metastatic breast cancer is a major cause of mortality among breast cancer patients (Sauer et al. Front Oncol: 11:659963, 2021). It may emerge years or even decades after the initial treatment of the primary tumor. This latency in the manifestation of the disease is attributed to the presence of early disseminated tumor cells (DTCs) that lay quiescent (dormant) for years until they emerge as clinically overt metastases. Given that to date we have no treatment to cure metastatic disease, it is vital to investigate ways to eradicate dormant DTCs and/or prevent their emergence to overt metastases. Here, we present a modified 3-dimensional in vitro system to model the in vivo growth characteristics of several tumor cell lines that exhibit either dormant behavior (D2.0R, MCF7) or transient dormant metastatic behavior (D2A1) at a metastatic secondary site. Additionally, we present an in vitro and complementary in vivo system to study the switch from dormancy to metastatic growth driven by a fibrotic-like milieu enriched with the deposition of type I collagen.
The data of all patients with abdominal wall aggressive fibroma were collected through the medical record system of the hospital, and the molecular characteristics of the disease were analyzed by sequencing of the specimens retained by previous surgery or paraffin specimens. The quality of life of patients was investigated by telephone or wechat follow-up to analyze the impact of postoperative disease on the quality of life of patients. As a retrospective and observational study, the data of this study will be statistically summarized according to the following general principles. Categorical data will be summarized descriptively using statistics including frequency n and percentage %, with 95% confidence intervals for overall percentages when necessary, and compared by chi-square or Fisher's exact test. Continuous data will be statistically described as mean ± standard deviation or median (min, Max) and compared by Mann-Whitney (U) test or t-test. The Kaplan-Meier method was used to estimate the survival function for time-to-event data, and survival curves were drawn to estimate the median time and 95% confidence intervals. The differences between groups were compared with the use of the Log-rank test. Cox proportional hazards model was used for univariate and multivariate analysis to screen independent prognostic factors related to recurrence, and the 95% confidence interval (CI) was recorded. All statistical tests were performed with the use of a two-sided 0.05 level. Statistical analysis will be calculated using SPSS 25 statistical analysis software.
The invention relates to the field of biology, and discloses application of dopa dioxygenase HhDODA1 and a coding gene thereof in enhancing radiation resistance. In particular to Henan Gao Shengxiong insects @ Henan Hypsibius    henanensis ) Dopa dioxygenase HhDODA1 and genes thereof, and their use in enhancing radiopacity. The dopa dioxygenase HhDODA1 hasHas the amino acid sequence shown as SEQ ID NO. 1, and the encoding gene has the nucleotide sequence shown as SEQ ID NO. 2. The HhDODA1 gene is derived from Henan Gao Shengxiong insects, is a novel dopa dioxygenase, and can remarkably improve the resistance of cells to ionizing radiation injury.
This is a a prospective, open-Label, and single-arm clinical study. This study aims to evaluate the efficacy and safety of using anlotinib in combination with doxorubicin monotherapy and radiotherapy as a neoadjuvant treatment for soft tissue sarcoma. For patients with the soft tissue sarcoma, the standard doxorubicin monotherapy regimen involves administering 37.5 mg/m² intravenously on days 1-2 of each 3-week cycle. The treatment includes 3 cycles of neoadjuvant chemotherapy (pre-surgery) and 3 cycles of adjuvant chemotherapy (post-surgery), totaling 6 cycles. Anlotinib (ALC) is administered at 12mg/d QD，day1\~14, 21d/cycle. Neoadjuvant radiotherapy is conducted before surgery, starting after the second chemotherapy cycle, using stereotactic body radiation therapy (SBRT) with a dose of 4\*10 Gy. Radical resection surgery is performed in the ninth week, after the third chemotherapy cycle.
A cross-sectional study of 350 medical student Universitas Indonesia from first grade until fifth grade was done during November-December 2016. This study used stratified randomized sampling. The Rome IV criteria was used for diagnosing IBS. Questionnaire-guided interview was applied to all subjects. A bivariate analysis was done to know the relationship between IBS and its related factors using chi-square, unpaired t-test, and their alternatives. Multivariate analysis was done using logistic regression test
OBJECTIVE: Adult-onset Still's disease (AOSD) is a multigenic autoinflammatory disease with a severe systemic involvement. Because of the rarity of the disease, most published cohorts are multicentric. The aim of this report is to describe a monocentric cohort of AOSD patients, reporting clinical features and response to therapy in a long follow-up.
METHOD: Thirty-eight patients, attending the Clinical Immunology Unit and fulfilling Yamaguchi, Fautrel, or Daghor-Abbaci classification criteria for AOSD, were recruited for this study. In all patients, clinical and serological data were collected at diagnosis and every 6 months thereafter. The Pouchot score was calculated at every visit.
RESULTS: Fever, arthromyalgia, and skin rash were the most frequent manifestations, followed by lymphadenopathy, sore throat, arthritis, splenomegaly, hepatic involvement, pleuropericarditis, and weight loss. As far as the disease course is concerned, 25% presented a monocyclic and 35% a polycyclic pattern, and 40% developed chronic articular involvement. Severe complications were observed at disease onset in 21% of the patients. All of the patients were treated with steroids; 74% also received conventional synthetic disease-modifying anti-rheumatic drugs (methotrexate in most cases) and 71% biological disease-modifying anti-rheumatic drugs (interleukin-1 inhibitors in most cases). Therapeutic switching for lack/loss of efficacy or adverse drug reactions was necessary in 66%.
CONCLUSION: The analysis of this cohort confirms that AOSD is a complex, severe, and heterogeneous disease. However, despite long-term treatment and comorbidities, therapies are effective and well tolerated. The therapeutic armamentarium now available allows long-lasting remission with low immunosuppression to be achieved in most patients.
Families Facing the Future (FFF) is an intervention designed specifically for families with a parent in methadone treatment. FFF is unique because it addresses prevention for children and recovery for parents in a single intervention. The primary goals of the program are to prevent parents' relapse, help them cope with relapse if it occurs, and teach parenting skills in order to reduce the likelihood of substance use among their children. FFF has been implemented as an adjunct to treatment in several Opioid Treatment Programs, but has not been widely adopted due to various implementation barriers. The aims of this study, therefore, were to (1) assess the perceived feasibility of implementing FFF and (2) identify/describe barriers to implementing FFF. An online survey was used to assess implementation feasibility, while individual qualitative interviews were conducted to explore specific barriers to implementation. Data collection from a total of 40 participants (20 patients and 20 providers) was conducted from August 2022 to October 2022 at two Opioid Treatment Programs in Florida. Analyses revealed high feasibility scores, indicating that FFF was viewed by both patients and providers as a practical intervention to implement. Despite strong perceived feasibility of the intervention, qualitative findings identified several implementation barriers with respect to difficulty attending parent training sessions, aversion to in-home visits, and lack of funding (inability to provide patient incentives/bill insurance). This study provides evidence that while patients and providers view FFF as having high feasibility, significant implementation barriers exist. This paper fills a void in the literature by informing if and which modifications might be necessary to facilitate wider adoption of FFF in real-world Opioid Treatment Program settings.
A system for controlling a device is provided. The system may include a remote control device and a safety control device communicating with each other via a wireless connection. The remote control device may be configured to remotely control the device. The remote control device may include a switch, a motion enable unit, and a hand control unit. The motion enable unit may be configured to generate processed information by processing information using a first secret. The hand control unit may be capable of acquiring the processed information from the motion enable device only when the switch is in a closed state. The hand control unit may be configured to transmit the processed information to the safety control device via the wireless connection. The safety control device may include a communication unit and a safety control unit. The communication unit may be configured to receive the processed information via the wireless connection. The safety control unit may be configured to verify the closed state of the switch by processing the processed information using a second secret that matches the first secret. Further, the safety control unit may be configured to enable control of the device when the closed state of the switch is verified.
OBJECTIVE: The objective of this study was to investigate the allele frequencies of polymorphisms in genes CYP11A1 rs4886595 and CYP11A1 rs4887139 that are responsible for the steroidogenesis mechanism in polycystic ovary syndrome patients and control females.
METHODS: Samples were obtained from the Department of Obstetrics and Gynecology in the Near East University Hospital from September 2019 to December 2019. Only the nonobese patients between the ages of 18-40 years were included in this study following informed consent. Obese patients and patients more than 40 years of age were excluded from the study. Nonobese women and normal ovulation were included in the control group. DNA was isolated from blood samples. Real-time polymerase chain reaction (PCR) was used to analyze single nucleotide polymorphisms (SNPs) in various genes linked to polycystic ovary syndrome. The studies were carried out using the samples obtained from 120 women, of whom 55 were nonobese and had normal ovulation, and 65 were polycystic ovary syndrome patients. The allelic frequencies of SNPs in genes linked to polycystic ovary syndrome were calculated using real-time PCR outcomes.
RESULTS: The variation of the CYP11A1 rs4887139 G>A did not show any significance, while the variation of CYP11A1 rs4886595 C>A showed significant differences between the patient and the control groups (p=0.01), respectively.
CONCLUSION: Future research ought to focus on elucidating the susceptible causes of polycystic ovary syndrome with a wide range of SNPs and more sample size. The genome-wide association studies in polycystic ovary syndrome patients of different origin will be important to identify candidate genes as well as proteins that are implied in polycystic ovary syndrome risk.
PURPOSE: A method for preparing processed ginseng having enhanced ginsenoside content is provided. CONSTITUTION: A ginseng is hydrolyzed by adding enzyme so the content of ginsenoside which is isolated from a processed ginseng or its extract is enhanced. The enzyme is β-glucanase, pectinase, hemicellulase, cellulose, arabinase or xylanase. The ginseng is red ginseng. The ginsenoside is Rg2, and the enzyme is pectinase, hemicellulase, or cellulase. The ginsenoside is Rg3, and the enzyme is beta-glucanase, pectinase, hemicellulase or cellulase. The hydrolysis is performed before or together with the extraction. A health food composition contains the processed ginseng or ginseng extract as an active ingredient. The health food composition further contains gamma cyclodextrin.
Introgression allows polyploid species to acquire new genomic content from diploid progenitors or from other unrelated diploid or polyploid lineages, contributing to genetic diversity and facilitating adaptive allele discovery. In some cases, high levels of introgression elicit the replacement of large numbers of alleles inherited from the polyploid's ancestral species, profoundly reshaping the polyploid's genomic composition. In such complex polyploids, it is often difficult to determine which taxa were the progenitor species and which taxa provided additional introgressive blocks through subsequent hybridization. Here, we use population-level genomic data to reconstruct the phylogenetic history of Betula pubescens (downy birch), a tetraploid species often assumed to be of allopolyploid origin and which is known to hybridize with at least four other birch species. This was achieved by modeling polyploidization and introgression events under the multispecies coalescent and then using an approximate Bayesian computation rejection algorithm to evaluate and compare competing polyploidization models. We provide evidence that B. pubescens is the outcome of an autoploid genome doubling event in the common ancestor of B. pendula and its extant sister species, B. platyphylla, that took place approximately 178,000-188,000 generations ago. Extensive hybridization with B. pendula, B. nana, and B. humilis followed in the aftermath of autopolyploidization, with the relative contribution of each of these species to the B. pubescens genome varying markedly across the species' range. Functional analysis of B. pubescens loci containing alleles introgressed from B. nana identified multiple genes involved in climate adaptation, while loci containing alleles derived from B. humilis revealed several genes involved in the regulation of meiotic stability and pollen viability in plant species.
PURPOSE:To obtain a spraying gel base excellent in spreadability by disintegrating an agar jelly by mechanical stimulation. CONSTITUTION:A spraying gel base is obtained by mixing agar with water, thermally dissolving the mixture, cooling and solidifying the prepared solution, uniformly disintegrating the formed solid with a homomixer, etc., regulating the viscosity to 100-600 cP at 20 deg.C and further preferably blending a water-soluble polymer compound (e.g. hydroxypropyl cellulose) therewith. The spraying gel base is excellent in its spreadability even at a low viscosity without causing liquid sagging with hardly any change in viscosity before and after the spraying and has a constant grain diameter. An active medicine can be blended in the gel base to provide a spraying nasal drop. Thereby, the medicine can steadily be released to the mucous membrane of the nasal cavity.
Subjects will need to complete two questionnaires on admission and on discharge from the PRC program to measure self-efficacy and depression. The first is the Pain Self-Efficacy Scale (PSEQ) which is a measure of self-efficacy in persons with chronic pain. The second questionnaire is the Center for Epidemiologic Studies Depression Scale (CES-D) which is a measure of depressive symptoms in persons with chronic pain. Both scales will also be used for clinical information. Persons who score 27 or higher on the CES-D will be approached for potential consent to this evidence based project. Each patient in the PRC will participate in up to 6 CBT sessions but only persons who, upon admission, score 27 or greater on the CES-D will be studied for any changes in scores from admission to discharge.
Position of therapist: stands beside the patient, while his\\her head is cradled between your body and your right forearm (when you stand at his\\her right side). Gentle pressure is now applied in a ventral direction on the spinous process of C7 while the skull remains still due to the control of your right forearm. (The really gentle moving force to do this comes from your left arm via the thenar eminence over the little finger on the spine of C7).
It can be used after schizophrenia is diagnosed. Risperidone affects prolactin and may affect menstruation in young women, so we will try not to use it in such patients. Patients were randomized to a single Risperidone control trial for 8 weeks to evaluate the clinical efficacy of the patients. Risperidone routine daily 2-6 mg, up to 8 mg, can be taken orally twice a day.
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF\>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. It is closely adjacent to the coronary arteries and myocardium. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients. This study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with HFpEF, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.
A phosphorylated hesperidin containing 10.9 -21.8% of phosphorus by weight for use in compositions for parenteral administration (see Group VI) is prepared by dissolving hesperidin in pyridine, intimately commingling the resulting solution and phosphorus oxychloride at approximately room temperature, quenching the mixture in water at a temperature below about 40 DEG  C., filtering it, treating the filtrate with a lower aliphatic alcohol, and recovering the phosphorylated hesperidin thereby precipitated as a salt.  The salt may be further purified and/or reconverted to the free ester.ALSO:A composition for parenteral administration comprises an antigen or an allergan and a biochemically active phosphorylated hesperidin which contains between 10.9 and 21.8% by weight of phosphorus.  The hesperidin derivatives are defined in relation to biochemical activity and in particular to three critical tests; if they are active with respect to these tests they are suitable for use in the compositions.  When incorporated with antigens or allergens they act as potentiating agents and longer lasting, more effective immunologic compositions are obtained.  Immonologic agents which may be employed are bacterial and viral antigens, allergens and toxoids, e.g. diphtheria, tetamus and staphylococcus toxoids; pertussis, catarrhitis, common cold, poliomyelitis, rabies, smallpox, pneumo-strepto, typhoid, paratyphoid and undulant fever vaccines; influenza viral antigens; poison ivory extract, timothy, ragweed, and mixed grass allergens and dust pollen extracts.  Suitable carriers for the compositions are water, physiological saline solution, water-in-oil or oil-in-water emulsion, an oil suspension, or a solution of gelatin, pectin, methyl cellulose, carboxymethyl cellulose or polyvinyl pyrrolidone.  Alternatively the compositions may be freeze dried and reconstituted for injection prior to use.
Patient will be disconnected from the anesthetic circuit and connected to the resuscitation bag attached to the IH system. With O2 flow of 2 L/min patient will be gently ventilated until recovery of the spontaneous ventilation. After starting spontaneous ventilation basal O2 flow will be adjusted to keep ETCO2 in range of 50-60 mm Hg or minute ventilation of 15-17 L/min, whichever occurs first.