anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Little is known about the eating habits of children under laboratory conditions. In this exploratory study, we aim to examine the relationships between measured food intake during meals, binge eating behaviors as assessed by interview, and polymorphisms in genes believed to be involved in the regulation of energy intake. We will study children who report they have experienced loss of control over eating, children who report overeating without loss of control, and children who report neither of these episodes, and assess the impact of two different meal instructions on their eating behavior. We will ask children to eat a meal in the laboratory setting on two occasions. The only difference between the two meals will be a pre-meal instruction: Participants will be asked either to eat 'normally' (the 'normal meal' instruction) or to 'let yourself go' (the 'binge meal' instruction). Participants will be assessed for affective state; degree of hunger, fullness, and desire to binge; presence of overeating or loss of control; eating attitudes and dieting; and general school and social adjustment. Participants' DNA will be sequenced to seek polymorphisms in genes relevant for appetite, such as the leptin and melanocortin 4 receptor genes, to examine whether genetic variation in the leptin signaling pathway can account for variation in reported or actual eating behaviors. Samples will also be obtained for hormones believed to be relevant for food intake. By accurately describing eating behavior in children in relation to their age, weight, history of dieting and/or overeating behavior, and genetic variation, we can refine current theoretical models of disordered eating.
Pazopanib is a kinase inhibitor. Pazopanib is presented as the hydrochloride salt, with the chemical name 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide hydrochloride. It has the molecular formula C21H23N7O2S•HCl and a molecular weight of 473.99 g/mol. Pazopanib hydrochloride has the following chemical structure:

Pazopanib hydrochloride is a white to slightly yellow solid. It is very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.

Pazopanib tablets are for oral use. Each 200 mg tablet of pazopanib contains 200 mg of pazopanib equivalent to 216.7 mg of pazopanib hydrochloride. The inactive ingredients of pazopanib tablets are: Tablet Core: Magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate. Coating: Grey film-coat: hypromellose 2910, iron oxide black, polyethylene glycol 400, polysorbate 80, and titanium dioxide.
Subjects in this group were unprimed in the primary study 115345 (NCT01439360) and received 2 doses of Fluarix Quadrivalent vaccine at Days 0 and 28 in the current study. The vaccine was administered intramuscularly in the deltoid region of arm.
PROBLEM TO BE SOLVED: To obtain a composition, hardly diffusing a medicine from a rectal tissue and enhanced in persistence of the medicine in the rectal tissue by using the medicine used for hemorrhoids or cancer of the rectum with a specific base and a vasoconstrictor in combination. SOLUTION: This long acting composition for rectal administration is obtained by using a therapeutic agent for rectal tissues and a retentive base ingredient for rectal administration and a vasoconstrictor in combination. One or more acrylic acid polymer, an alkali metallic salt of a polygum, a a phyllosilicate mineral and an acrylated starch are preferred as the retentive base ingredient for the rectal administration. Among them, the acrylic acid polymer is preferred (a carboxyvinyl polymer is especially preferred). One or more of tetrahydrozoline hydrochloride, naphazoline hydrochloride or oxymetazoline hydrochloride are preferably used as the vasoconstrictor. The acrylic acid polymer is blended in an amount of 0.1-20wt.% based on the total amount of the composition and the vasoconstrictor is blended in an amount of 0.005-2.0wt.% based on the total amount of the composition.
Autism spectrum disorders (ASD) are common neurodevelopmental syndromes affecting 1% of U.S. children. Comorbid anxiety disorders affect 40 to 50% of children with ASD, causing substantial distress and impairment over and above that caused by ASD alone. Although standard practice cognitive-behavioral therapy (CBT) has been established as an efficacious and safe treatment for anxiety disorders among typically developing youth, its utility in comorbid cases with ASD remains unknown. To date, no studies have experimentally compared standard practice CBT to a cognitive-behavioral intervention that has been personalized for children with a comorbid presentation of anxiety and ASD. Accordingly, we are proposing a randomized controlled trial to be conducted at three treatment sites to evaluate the efficacy of personalized CBT for anxiety in ASD (Behavioral Intervention for Anxiety in Children with Autism: BIACA) relative to standard practice CBT for anxiety (Coping Cat program). Furthermore, this study will employ a waitlist control group to assess the efficacy of each CBT arm relative to the absence of treatment (i.e., a Waitlist control arm). The proposed research will: (1) examine the efficacy of BIACA relative to Coping Cat, which represents standard practice treatment, and the efficacy of both these treatments relative to a waitlist control group, (2) evaluate the maintenance of treatment gains, (3) examine the impact of personalized intervention on functional outcomes. A total of 201youth across 3 study locations (ages 8-13 years) with ASD and co-occurring anxiety will be randomly assigned to one of the three conditions. The three recruitment sites for this study are University of California, Los Angeles, the University of South Florida (USF), and Temple University. Considering the rising number of children diagnosed with ASD together with the frequency and severity of comorbid anxiety, the proposed work is tailored to the unique needs of youth with ASD and will provide a timely contribution to public health efforts.
Malignant neoplasms were observed in 20 of 4127 (0.5%) XOLAIR-treated patients compared with 5 of 2236 (0.2%) control patients in clinical studies of adults and adolescents ≥12 years of age with asthma and other allergic disorders. The observed malignancies in XOLAIR-treated patients were a variety of types, with breast, non-melanoma skin, prostate, melanoma, and parotid occurring more than once, and five other types occurring once each. The majority of patients were observed for less than 1 year. The impact of longer exposure to XOLAIR or use in patients at higher risk for malignancy (e.g., elderly, current smokers) is not known.

In a subsequent observational study of 5007 XOLAIR-treated and 2829 non-XOLAIR-treated adolescent and adult patients with moderate to severe persistent asthma and a positive skin test reaction or in vitro reactivity to a perennial aeroallergen, patients were followed for up to 5 years. In this study, the incidence rates of primary malignancies (per 1000 patient years) were similar among XOLAIR-treated (12.3) and non-XOLAIR-treated patients (13.0) [see Adverse Reactions (6.1)]. However, study limitations preclude definitively ruling out a malignancy risk with XOLAIR. Study limitations include: the observational study design, the bias introduced by allowing enrollment of patients previously exposed to XOLAIR (88%), enrollment of patients (56%) while a history of cancer or a premalignant condition were study exclusion criteria, and the high study discontinuation rate (44%).
The maternal microbiome plays a vital role in shaping pregnancy outcomes, but there remains a substantial gap in understanding its precise relationships to maternal health, particularly in relation to potential effects of body mass index (BMI) on gut microbial diversity. The aim of this observational study was to assess maternal characteristics in association with pre-pregnancy BMI and to further assess microbial diversity in association with specific maternal characteristics. Eighty-four pregnant women were recruited during their third trimester of pregnancy from various prenatal clinics across the state of Michigan. The participants completed an enrollment questionnaire including self-reported pre-pregnancy BMI; stool samples were collected to assess the fecal microbial community composition. Pre-pregnancy obesity (BMI 30+) was associated (univariably) with antibiotic use before pregnancy, ever smoked, lower education level, and being unmarried. The gut microbiota alpha diversity was significantly different for pregnant women by pre-pregnancy BMI category (normal, overweight, obese). The beta diversity was unique for the gut microbiotas of pregnant women within each BMI category, by education level, and by marital status. Multivariable models revealed that pre-pregnancy BMI, maternal education, marital status, and maternal age were associated with the microbial diversity of the gut microbiota during pregnancy. These results give new insight into the relationship between a woman's microbiome during pregnancy and their prenatal health, along with an understanding of the relationships between socioeconomic factors and microbial diversity.
BACKGROUND: The early prediction of adolescent depression recurrence poses a significant challenge in the field. This study aims to investigate and compare the abilities of the general psychopathology factor (p) and the specific internalizing factor, in predicting depression recurrence over a 2-year course, as well as identifying remitted depressed adolescents from healthy adolescents. Longitudinal changes of these two factors in different trajectory groups were also tracked to examine their sensitivity to sustained remission and relapse.
METHODS: We included 255 baseline-remitted depressed adolescents and a healthy control group (n = 255) matched in age, sex, and race, sourced from the Adolescent Brain Cognitive Development Study. The linear mixed model was employed for the statistical analysis.
RESULTS: The p factor not only effectively discriminated between remitted depressed adolescents and healthy controls but also robustly predicted the depression recurrence over a subsequent 2-year course. The specific internalizing factor could only differentiate remitted depressed adolescents from healthy controls. Additionally, a noteworthy longitudinal decline of the p factor in the sustained-remission group was observed.
CONCLUSIONS: Psychopathology factors serve as the inherent and enduring measurement of long-term mental health aberrations. Longitudinal results indicate that the p factor is more sensitive to respond to sustained remission than the internalizing factor. The ability of the overall p factor to anticipate depression relapse, unlike the specific internalizing factor, suggests the clinical interventions should monitor and mitigate the coincident symptoms across all dimensions to preempt relapse of adolescent depression, rather than an exclusive focus on internalizing symptoms.
The present invention discloses a rose hip-ginseng traditional Chinese medicine preparation for invigorating the kidney and strengthening yang and a preparation method thereof, which relates to a Chinese medicine preparation for treating syndromes of extreme asthenia of kidney yang caused by vacuity following illness and anenergia of persons in middle and old age and a preparation method thereof. The Chinese medicine preparation has the functions of strengthening bodies by means of nourishment, invigorating the kidney, strengthening yang, benefiting the spleen, boosting qi, enhancing the vigour, resisting fatigue and strengthening organic resistibility, and can be used for treating syndromes of extreme asthenia of kidney yang of pain in the waist and knees, cold extremities, aversion to cold, dizzy head and vision, lassitude, hypaphrodisia, etc. The preparation is prepared from the following raw materials: 15 to 40 wt% of epimedium herb, 0.5 to 2.0 wt% of ginseng fruit glycoside and 40 to 80 wt% of rose hip. The Chinese medicine preparation has the functions of resisting fatigue, resisting oxygen deficiency, tranquilizing mind, promoting phagocytic functions of mononuclear macrophages, improving physical strength, endurance and nonspecific resistibility and enhancing organic immunity and disease resistance. The Chinese medicine preparation has the functions of lowering MAO-B activity in brains of mice, increasing SOD activity, increasing organic antioxidant ability and resisting ageing. The Chinese medicine preparation is safe and reliable, and is an ideal medicine for treating syndromes of extreme asthenia of kidney yang.
Purpose: To report multimodal imaging features of an unusual case of multiple focal choroidal excavations (FCE) associated to macular intrachoroidal cavitations (ICC) and choroidal neovascularization (CNV) in a non-myopic patient with normal choroidal thickness. Methods: Observational case report. Results: A 69-year-old non-myopic male patient with history of macular CNV of unknown etiology in the right eye (RE), initially treated with Bevacizumab intravitreal injections with significant improvement of visual acuity. He presented with acute vision loss in the same eye related to recurrent CNV exudation. Multimodal imaging of the RE confirmed the diagnosis of active type 2 CNV, associated to multiple FCE. Besides, it highlighted incidental unusual macular ICC in the same eye. Choroidal thickness was within normal limits (217 μm). Conclusion: Focal choroidal excavations and intrachoroidal cavitations can be observed in emmetropic patients in the absence of pachychoroid disease. In presence of CNV of unknown etiology, complete multimodal imaging can be of a great help to better define choroidal anomalies, allowing structural and vascular correlations between different lesions. Key words: Focal choroidal excavation; Choroidal cavitation; Multimodal imaging.
The modern environment is obesity-promoting, with easy access to palatable, energy-dense foods and appealing sedentary activities. Despite this overarching environment, some individuals are able to maintain a normal weight status, suggesting that there are individual differences in susceptibility to obesity-promoting environments. The RRV of food captures individual differences in the motivation to eat by measuring how hard individuals will work for access to food versus other activities, and it has been shown to predict weight outcomes among infants, children, and adults. In a pilot study with infants, Kong, Eiden, Epstein, et al. demonstrated support for this hypothesis as providing infants and parents with access to group music classes increased infants' reinforcing values of music relative to food. Compared to other age groups, less research has been conducted on the RRV of food in preschool children. Filling this gap in the literature is important, as the preschool period is a period of drastic transitions, including extensive learning of food preferences and habits. Studies have also shown that obesity during adolescence is more likely among children who are already overweight by age 5, further highlighting the importance of innovative approaches to childhood obesity prevention prior to school entry.

In the proposed study, we aim to bring together the literature on food reinforcement and the literature on parenting interventions in early childhood by promoting positive, rewarding parent-child interactions as a novel alternative reinforcer to decrease the RRV of food. Positive parenting can be defined as sensitive, responsive parenting, where parents' responses are appropriate for and contingent upon the child's cues and developmental level. This style of parenting early in life has been linked to positive cognitive and socio-emotional outcomes in adolescence and beyond. The focus of the present study is to assess the initial efficacy of the present parenting intervention, as well as its feasibility. This study will pave the way for future testing of this intervention's effects on the RRV of food and other positive developmental and health outcomes.
The invention relates to a streptococcus zooepidemicus strain (also called streptococcus zooepidemicus subspecies, Streptococcus equi  subsp. zooepidemicus ) XJMSY16-1, CGMCC No.12428, has a 16S rRNA gene sequence in a sequence table 1; the strain is isolated from horse with streptococcus equi disease, gram-positive bacteria, cells are spherical, arranged in pairs or in bent long chains, and have poor growth in common broth and flat plate; beta-type hemolysis occurs on a 5% sheep fresh blood plate, a completely transparent hemolysis band is formed around the dew-like microcolonies, and the width can reach 2.5-3.2 mm. The growth is facultative anaerobic, the growth temperature is 26-40 ℃, the optimal growth temperature is 37 ℃, and the optimal growth pH7.4-7.5. Glucose is fermented to produce acid, and lactose, mannitol and sorbitol cannot be fermented. The strain can be used for preparing inactivated vaccines for streptococcus equi disease. The vaccine prepared by the strain has good pertinence, low cost, safety and good protection effect.
FIELD: cosmetics. SUBSTANCE: composition is prepared on the basis of peroxide compounds as an oxidant and has also from 10 to 27 wt.-% at least one polymer taken from polyethylene glycols, polypropylene glycols or their derivatives. Polymer is anhydrous and liquid at the room temperature and soluble in water simultaneously. Method of preparing a composition involves mixing peroxide compound-base decolorizing powders at the room temperature and at the stage of stirring at least one polymer taken from polyethylene glycols, polypropylene glycols and their derivatives is added. Composition exhibits good fluidity, bleaches hair very good. EFFECT: improved quality, property and effectiveness of a composition. 8 cl, 1 tbl, 4 ex
ESRD: all patients with secondary hyperparathyroidism who are vitamin D naive will receive doxercalciferol 2 mcg or 4 mcg 3 times per week fopr 30 days (1 month). Blood work and vascular laboratory studies will be performed pre and post treatment.
This group will receive the standard injection technique first at the implant placement surgery and if the implant is placed as a two-stage procedure, during the second stage implant uncovery will receive the injection technique guided by the 3D dental scan (CBCT). If the implant is placed as a one-stage procedure, the second visit will not apply.
Fos-related antigen-2 (Fra-2) is a member of the activating protein-1 (AP-1) family of transcription factors. It is involved in controlling cell growth and differentiation by regulating the production of the extracellular matrix (ECM) and coordinating the balance of signals within and outside the cell. Fra-2 is not only closely related to bone development, metabolism, and immune system and eye development but also in the progression of respiratory conditions like lung tumors, asthma, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD). The increased expression and activation of Fra-2 in various lung diseases has been shown in several studies. However, the specific molecular mechanisms through which Fra-2 affects the development of respiratory diseases are not yet understood. The purpose of this research is to summarize and delineate advancements in the study of the involvement of transcription factor Fra-2 in disorders related to the respiratory system.
For the first 3 days after being switched from Nicotine Replacement Therapy (NRT) (occurring at one week after initiation of nicotine patch treatment, one week before the target Quit Day), smokers in this group will receive treatment with Chantix at a dose of 0.5 mg once per day followed by 0.5 mg twice a day for the remaining 4 days of that week. Subsequently, the dose will be 1 mg twice per day, and will remain at that dose for the remainder of the 12-week active treatment duration.
Usual Care with Education (UCE) will receive a pain educational booklet. Following completion of their 24 weeks in the study, they will also be invited to attend the monthly group educational sessions.
<P>PROBLEM TO BE SOLVED: To provide immunological reagents for therapeutic use in radioimmunotherapy (RAIT) and chemoimmunotherapy; and for detective and/or diagnostic uses in radioimmunodetection (RAID), ultrasonography and magnetic resonance imaging (MRI).  <P>SOLUTION: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. Constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them are provided.  <P>COPYRIGHT: (C)2009,JPO&INPIT
<P>PROBLEM TO BE SOLVED: To solve the problem that there are various methods in relation to a facial beauty cares but they are based on the caring of the skin in order to strictly expect the maintenance of the present condition of the skin or the temporary restoration of the skin and the substantial improvement of the skin is not achieved.  <P>SOLUTION: The blood flow of subcataneous blood capillaries becomes good and the metabolism of the skin becomes active by immersing a face in hot water with high carbonate concentration, of which the carbon dioxide gas is 500 ppm or above at 30°C or above, preferably for 5 min or above. By performing this face bathing method every day, the subcataneous blood capillaries are developed toward the skin to bring about the permanent improvement of the skin. A container having a goggle-like shape not closing a mouth or a nose or a container having a mask-like shape for spreading hot water with the high carbonate concentration to the whole of the face capable of performing nosal respiration is mounted on the face so that the face bathing by hot water with the high carbonate concentration is easily performed even by a person whose face can not immersed in water and hot water with the high carbonate concentration is injected in the container to hold the direct contact state of the skin of the face with hot water with the high carbonate concentration for 5 min or above. This method and this container device can be used in a facing upward state.  <P>COPYRIGHT: (C)2008,JPO&INPIT
BACKGROUND: Although the linear scalp incision is commonly used in neurosurgical practice, a systematic study elucidating its pros and cons in a specific surgical setting is lacking. Herein, we analyzed our experience with linear scalp incision in brain tumor surgery and the impact on intraoperative variables and postoperative complications.
METHODS: Patients undergoing brain tumor surgery (January 2014-December 2021) at 2 neurosurgical departments were included and divided into 2 groups: linear or flap scalp incision. Patients' demographics characteristics, surgical variables, and wound-related complications were analyzed.
RESULTS: More than a total of 1036 craniotomies, linear incision (mean length 6cm) was adopted in 282 procedures (27.2%). Mean maximum diameter of the craniotomy was 5.25 cm, with no statistical difference between the 2 groups. In emergency surgery (36 cases), the linear and flap incisions were used indifferently. Linear incision was predominant in supratentorial and suboccipital lesions. Flap incision was significantly more frequent among meningiomas (P < 0.01). Neuronavigation, operative microscope, and subgaleal drain were more frequently used in the flap scalp incision group (P = 0.01). Overall complication rate was comparable to flap scalp opening (P = 0.40).
CONCLUSIONS: The use of the linear incision was broadly applied for the removal of supratentorial and suboccipital tumors granting adequate surgical exposure with a low rate of postoperative complications. Tumors skull base localization resulted the only factor hindering the use of the linear incision. The choice of 1 incision over another didn't show to have any impact on intraoperative and postoperative variables, and it remains mainly based on surgeon expertise/preference.