anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a pellet containing saxalipitin. The pellet comprises a blank pellet core, an isolating layer, a medicine carrying layer and a protection layer. The blank pellet core is coated with the isolating layer to obtain an isolating pellet, and the weight of a coating material accounts for 10-20% of that of the blank pellet core. The isolating layer is coated with the medicine carrying layer which carries medicines including saxalipitin or salts and hydrates of saxalipitin and a coating material, the weight of the coating material accounts for 10-20% of that of the isolating pellet, a weight ratio of the medicines to the coating material is 1:2-8, and a medicine carrying pellet is obtained after the isolating pellet is coated with the medicine carrying layer. The medicine carrying layer is coated with the protection layer, and the weight of a coating material accounts for 10-20% of that of the medicine carrying pellet. The pellet containing the saxalipitin is high in content uniformity, stable in performance, high in dissolution rate and technically simple, thereby being a high-quality pharmaceutical preparation easy for industrialization.
PURPOSE: Individuals with amblyopia experience central vision deficits, including loss of visual acuity, binocular vision, and stereopsis. In this study, we examine the differences in peripheral binocular imbalance in children with anisometropic amblyopia, strabismic amblyopia, and typical binocular vision to determine if there are systematic patterns of deficits across the visual field.
METHODS: This prospective cohort study recruited 12 participants with anisometropic amblyopia, 10 with strabismic amblyopia, and 10 typically sighted controls (age range, 5-18 years). Binocular imbalance was tested at 0°, 4°, and 8° eccentricities (4 angular locations each) using band-pass filtered Auckland optotypes (5 cycles per optotype) dichoptically presented with differing contrast to each eye. The interocular contrast ratio was adjusted until the participant reported each optotype with equal frequency.
RESULTS: Participants with anisometropic and strabismic amblyopia had a more balanced contrast ratio, or decreased binocular imbalance, at 4° and 8° eccentricities as compared with central vision. Participants with strabismic amblyopia had significantly more binocular imbalance in the periphery as compared with individuals with anisometropic amblyopia or controls. A linear mixed effects model showed a main effect for strabismic amblyopia and eccentricity on binocular imbalance across the visual field.
CONCLUSIONS: There is evidence of decreased binocularity deficits, or interocular suppression, in the periphery in anisometropic and strabismic amblyopia as compared with controls. Notably, those with strabismic amblyopia exhibited more significant peripheral binocular imbalance. These variations in binocularity across the visual field among different amblyopia subtypes may necessitate tailored approaches for dichoptic treatment.
PROBLEM TO BE SOLVED: To prepare a urination regulator having excellent urination reflex inhibiting actions and low toxicity by formulating a specific bicyclic compound, above all, a specific new compound or its salt as an active ingredient therein. SOLUTION: This urination regulator is prepared by formulating a compound represented by formula I [A-ring is benzene ring; B-ring is a 4- to 7-membered isocyclic or heterocyclic ring; C-ring is a nitrogen-containing heterocyclic ring; X is C or N; Y is a direct bond or an alkylene; Ar<1> and Ar<2> are each an aromatic; (m) is 1-3] or its salt, especially a new compound represented by formula II [B'-ring is the B-ring; W is CH2 -CH2 or the like; (r) is 0-2] or its salt. 1,3- Dihydro-1-ethyl-3-phenyl-3-[2-(4-phenylpiperidino)ethyl]-2H-indol-2-one, etc. can especially be cited as the new compound represented by formula II. The compound represented by formula II is obtained by reacting, e.g. a compound represented by formula III (L is an eliminative group) or its salt with a compound represented by formula IV.
The present disclosure relates to optimizing sleep score parameters. In one embodiment, a first set of vectors is obtained, where each vector includes parameter values for sleep-related parameters used to calculate a sleep score. For each vector of the first set, a correlation value is determined, the correlation value indicating a degree of correlation between the vector and a user-indicated sleep score associated with a set of parameter values representing a sleep metric for the user. The second set of vectors is generated based on a first subset and a second subset of the first set of vectors satisfying a first criterion and a second criterion, respectively. A correlation value associated with each vector in the second set is determined. For each sleep-related parameter, parameter values of a given vector of the second set are assigned based on the correlation values associated with the second set.
We plan to enroll 72 volunteer patients with microalbuminuria. After 1 week waiting period (as the waiting list group), the patients will be randomized to treatment group A or group B.
Alkaline washing compositions comprise an alkali cleanser (i.e an inorganic material which is alkaline in reaction and possesses cleansing properties) and an amino tri-(alkylidenephosphonic acid) of formula <FORM:1056177/C4-C5/1> wherein X and Y are the same or different and are H or C1-4 alkyl, or a water-soluble salt thereof. Specified alkaline agents are alkali metal and ammonium hydroxides and carbonates, preferably NaOH in a concentration of 1-20% of an aqueous composition.  The preferred amino tri-(alkylidene phosphonic acid) is amino tri-(methylphosphonic acid) in the form of its penta-sodium salt (see Division C2).  The phosphonic acid component of the compositions acts as a sequestering agent for metal cations (see Division C1).  The compositions are used to wash bottles and glassware and may contain an anti-corrosive agent.ALSO:Amino tri(methylphosphonic acid) is prepared by condensing diethyl phosphite with ammonia and formaldehyde in aqueous medium to give hexaethyl amino tri(methylphosphonate) which is hydrolysed with conc. HCl; the pentasodium salt of the acid is prepared by reaction of the acid with aqueous NaOH.ALSO:Compositions containing an amino tri-(alkyldene-phosphonic acid) of formula <FORM:1056177/C1/1> wherein X and Y are H or C1- 4 alkyl or a water-solubl salt thereof are used to sequester heavy metal ions (e.g. Fe+ + +, Fe+ +, Co+ +, Mn+ +) in aqueous solutions.
Participants in the control condition will be asked to complete three 15 minute creative writing exercises online via Qualtucs over approximately six days. Participants completing the first writing exercise will be sent links to the second and third writing exercises.
Tinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus. It is a frequent problem which can interfere significantly with the ability to lead a normal life. One significant modulator of tinnitus is stress. Tinnitus has been shown to be generated in the brain, as a result of functional reorganization of auditory neural pathways and the central auditory system. Also non-auditory cortical areas of attention allocation and emotional processing was shown to be involved. Treatment remains difficult. The most effective treatment in chronic tinnitus is cognitive behavioral therapy including elements of relaxation therapy. Repetitive transcranial magnetic stimulation (rTMS) is also effective in treatment of tinnitus with moderate effect size. Pilot data were positive for low-frequency rTMS applied to the temporoparietal areas and high-frequency rTMS applied to the left frontal cortex. Newer findings indicate that exercise-combined non-invasive brain stimulation might show superior effects in contrast to rTMS or exercise alone. Combination of relaxation and two-sided (frontal and temporo-parietal) rTMS will be examined with regard to feasibility, safety and clinical efficacy in patients suffering from chronic tinnitus in a pilot trial.
This invention discloses a method of editing, accessing, creating, and retrieving database information in a medical services business wirelessly. The wireless device could be a PDA, laptop, a computer, or any telephony device. The database information extends from pre-admission, to treatment, to post-admission, hospitalization, and post-hospitalization data. It also covers EMS operations and interactions with hospitals. It covers patient and physician history and laboratory diagnosis. It describe method of wirelessly generating healthcare provider notes and the authentication of such notes. The information transmittal is secured by an elaborate authenticating scheme disclosed here. The disclosure covers all fields and activities of current medical care now transformed from wired or paper to wireless by various devices.
The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including platinum-based chemotherapeutics, to treat cancers such as ovarian cancer. Furthermore, the invention provides for compositions and methods for predicting an individual's responsivity to salvage therapeutic agents. By predicting if an individual will or will not respond to platinum-based chemotherapeutics, a physician can reduce side effects and toxicity by administering a particular additional salvage therapeutic agent. This type of personalized medical treatment for ovarian cancer allows for more efficient treatment of individuals suffering from ovarian cancer. The invention also provides reagents, such as DNA microarrays, software and computer systems useful for personalizing cancer treatments, and provides methods of conducting a diagnostic business for personalizing cancer treatments.
Osteogenesis imperfecta (OI) is known to cause hearing loss in ~60% of the affected human population. While OI-related pathologies have been studied in the middle ear, the development of cochlear pathologies is less well understood. In this study, we examine OI-related pathologies of the cochlea in a mouse model of OI to (1) document variation between OI and unaffected mice, and (2) assess the intrusion of the otic capsule onto the cochlea by analyzing differences in duct volumes. Juvenile and adult OIM C57BL/6mice were compared to unaffected wildtype (WT) mice using three-dimensional models of the cochlea generated from high resolution micro-CT scans. Two-tailed Mann-Whitney U tests were then used to investigate duct volume differences both within and between the OI and WT samples. Areas of higher ossification were observed at the cochlear base in the OI sample. OI mice also had significant intraindividual differences in duct volume between right and left ears (4%-15%), an effect not observed in WT mice. WT and OI duct volumes showed a large degree of overlap, although the OIM volumes were more variable. Our findings indicate that OIM mice are likely to exhibit more asymmetry and variation in cochlear volume despite minor differences in sample cochlear volumes, possibly due to bony capsule intrusion. This suggests a potential mechanism of hearing loss, and a high potential for cochlear and otic capsule alteration in OIM mice.
The invention discloses an immunomodulatory peptide BugaCATH and application thereof. Belongs to the biomedical field. The immunomodulatory peptide Buga CATH is a cyclic polypeptide of which the sixth cysteine and thirteenth cysteine form a pair of intramolecular disulfide bonds and are encoded by Chinese amphibian Chinese toad skin repair peptide genes, the molecular weight of the CATH is 3156.67 daltons, the isoelectric point of the CATH is 8.76, and the amino acid sequence of the CATH is shown as SEQ ID NO. 2. Encoding immunomodulatory peptides Buga The CATH precursor gene (GenBank accession: OQ 870533) consists of 663 nucleotide sequences, and the nucleotide sequences are shown in SEQ ID NO. 1; wherein the 322-448 nucleotide is an immunomodulatory peptide Buga The coding gene of CATH. Immunomodulatory peptides Buga CATH in preparation of skin wound repair promoting agentThe application of the medicine in the treatment of the diseases.
This Emergency Department (ED) based study will test the effectiveness of a tailored therapist delivered motivational interviewing intervention, and an informational pamphlet control condition (IC) on reducing violence in 14-20 year olds who present to the Hurley Medical Center (HMC). Eligible adolescents at the Hurley Medical Center (HMC) emergency department (ED) (based on eligibility criteria) will complete a computerized online survey. The goal of the intervention was to examine ways to reduce and prevention youth violence using techniques to change behavior in a respectful, non-confrontational, and non-judgmental manner. This one-on one counseling approach emphasizes individual choice and responsibility and differentiates between future goals/values and current behavior. At 2-months following their ED visit, eligible adolescents (both from the intervention group and control group) will meet with a research assistant and self-administer an online computerized follow-up survey. An online survey tool will be used for baseline, follow up and post-test surveys. Participants will self-administer the survey at the time of follow up, post-test and baseline.
As spinal cord stimulation (SCS) becomes a staple of chronic pain management, the SCS industry must constantly evolve to ensure safety, convenience and enhanced efficacy. Beyond waveforms and size, MR-conditionality is a key differentiator sought out by physicians and patients when choosing SCS devices. Many common SCS complications, including lead migration, can affect the MR-conditionality. The authors reviewed literature published between 2015 and 2024 using PubMed and Google Scholar databases, as well as US FDA labels for magnetic resonance imaging and technical manuals with further confirmation from local representatives. Through extensive review of the literature and direct extraction from each SCS device company, the authors aimed to investigate the specific terms of MR-conditionality under various circumstances. This article provides a collective reference of the MR-conditionality of the currently available SCS devices under normal conditions, as well as with common failure modes, such as lead migration, lead fracture and battery detachment.
OBJECTIVE: To determine (i) the prevalence of overweight and obesity among children presenting to all EDs in a large regional Australian city and (ii) whether age, sex, socioeconomic status (SES) or hospital setting (public vs private) were associated with overweight and obesity.
METHODS: This prospective observational study included children aged ≥2 and <18 years who presented to any of three EDs over an 18 month period who had their height and weight measured. Age, sex and residential postcode were collected. Weight category was determined by sex and age standardised body mass index (BMI) z-score. Weight category was assessed by sex, age, SES and hospital setting with chi-squared tests, and ordinal logistic regression with cluster sandwich error estimators. Results were reported using odds ratios (OR) with 95% confidence intervals (CI).
RESULTS: Data were collected for 3827 children, of which 11.6% were obese and 19.8% overweight. The prevalence of obesity was highest in those aged 8-14 years and in those from lower SES postcodes. The likelihood of obesity was higher in the public than the private hospitals (OR 0.66, 95% CI 0.51-0.86), whereas the likelihood of overweight was similar (OR 1.00, 95% CI 0.83-1.22).
CONCLUSIONS: Almost one-third of children who presented to EDs were overweight or obese. Obesity was particularly high in those aged 8-14 years and those from lower SES postcodes. In the evolving obesity crisis, the high proportion of children presenting to EDs above a healthy weight might represent an opportunity for EDs to identify and refer children for body weight and lifestyle management.
Steps in short: Single tooth in the esthetic zone requiring full coverage crown is prepared to receive an all-ceramic crown, The restorations will be divided into two groups: I: Teeth receiving restorations fabricated from Lithium disilicate II: Teeth receiving restorations fabricated from yttria stabilized multilayered zirconia. Shade will be measured using intraoral spectrophotometer and evaluated. The colour difference (ΔE) will be calculated for each sample using the following equation: ΔE =\[(ΔL) ²+(Δa) ² + (Δb) ²\] ½, ΔE (perceptibility threshold) will be evaluated for each group. Participant timeline the patient will be treated in visits designated as follows: Visit 1: Preoperative records, face-to-face adherence reminder session, clinical, radiographic for examination, intraoral photographs and primary impression (Alginate impression) diagnostic cast construction. Visit 2: teeth preparation and secondary impression using addition silicone rubber base material and temporary restoration. Visit 3: placement and permanent cementation of the final restoration using resin cement.
[Problem] It is impossible to ensure the integrity of data immediately after analog-digital conversion for initiating the distribution of digital data. It is impossible to acquire information using a simple method. It is impossible to provide knowledge based on different types of information. Thus, it is difficult to facilitate the resolution of difficult problems or the elimination of intractable diseases. [Solution] The present invention is composed of a construct in which an analog-digital conversion unit and a digital data holding unit have been integrated such that digital data is not output to the outside of the integrated construct until it is detected that information pertaining to the digital data has been completely recorded in a blockchain, thereby preventing the falsification and ensuring the integrity of the digital data. Stimulation is applied and information is acquired using a simple light-reception/emission unit. Information pertaining to health and information pertaining to behaviour are associated and provided as knowledge. The association of information in a blockchain platform system facilitate the resolution of difficult problems and the elimination of intractable diseases.
Adjuvants are a critical ingredient in most vaccines and act by boosting the immune response to the target protein (e.g. hepatitis B surface antigen (HBsAg)). Despite considerable research, aluminium hydroxide or phosphate compounds (collectively referred to as "alum") remain the dominant adjuvants used in human hepatitis B virus vaccines. There is thus an unmet need for new HBV vaccine adjuvants, in particular, for adjuvants capable of boosting cell-mediated immunity (this is a particular type of immune response where killer T cells are activated that are then able to attack and destroy the infection) as alum, although good at stimulating antibodies is very poor at stimulating cell-mediated immunity. Alum, whilst generally accepted as safe, can be associated with significant local vaccine reactions and this is another reason why newer better-tolerated vaccine adjuvants would be beneficial. This study will compare a range of experimental adjuvant formulations to identify those that provide the safest and most effective enhancement of T- and B-cell immunity against hepatitis B
The present invention is concerned with a process for the formation of dental restorations from glass-ceramic materials and the resulting dental restorations. In this invention, a dental restoration is prepared by placing a glass-ceramic material in a heat-pressure deformable crucible. Heat is then applied to the crucible in order to bring the glass-ceramic material to a working range at temperatures above its liquidus temperature. The crucible in which the glass-ceramic material is placed has heat-pressure deformation properties which are matched to the working temperature of the glass-ceramic material being heated. The heat deformation properties of the crucible must be such that when the glass-ceramic material in the crucible is in the working range the crucible is heat-pressure deformable without rupturing. Once the glass-ceramic material is heated to its working temperature, the crucible is brought into contact with a mold having a preformed cavity therein, the cavity being in the shape of the desired dental restoration.      As the distance between the heated glass-ceramic material and the mold is decreased, the crucible is deformed to form a seal with the mold thereby facilitating the injection of the molten glass-ceramic material into the mold cavity. An interactive seal between the crucible and the mold may be provided for. The composite process may be carried out in a vacuum. The resulting dental restoration has superior optical esthetic and strength properties. The invention further includes the heat-pressure deformable crucible which is useful in the process of this invention and the related apparatus.
Patients with breast cancer often report fatigue and other associated symptoms that persist for months, even years, after treatment ends. In a recent pilot study of Qigong/Tai Chi Easy (QG/TCE, a low-intensity form of Meditative Movement), fatigued breast cancer survivors experienced greater improvements in fatigue (medium effect size, .56); compared to a "sham" Qigong control intervention (also low-intensity activity). Trends for improvement compared to control were found for sleep quality and depression. Recruitment for the single-site implementation was steady, and feasible. To build upon the promise of this pilot study, and to further test intervention components that may elucidate what aspects of the intervention have the most impact, a three-group, randomized trial will be undertaken to test effects of an 8-week QG/TCE intervention on fatigue and other symptoms at the end of 8 weeks, and 24 weeks post-intervention. 246 (attrition to 210) women who are 6 months to 10 years past treatment for Stage 0- III breast cancer, aged 45-75, and post-menopausal, will be randomized into one of three study arms. Two comparison groups will be used, an educational support (ES) group control and an active sham Qigong (SQG) group with movements that are similar to and with the same level of physical activity intensity as QG/TCE, but without the focus on the breath and meditative state. These treatments allow for separation of effects associated with gentle exercise alone (controlled in SQG) and education/social support alone without any exercise (controlled in ES) relative to the mind-body practice of QG/TCE, to distinguish unique effects of the meditative and breath foci. The study will be implemented in two sites in a large, metropolitan area, including one low-income hospital (and catchment neighborhood) with larger numbers of Latina survivors where our research team has extensive community connections and cultural experience implementing exercise and meditative movement programs. Psychometrics and biomarkers related to symptoms before and after the interventions will be examined to further our understanding of the mechanisms associated with effects of QG/TCE, as distinct from ES and SQG.