anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
To investigate the long-term effects of 2 commonly used low-osmolar contrast media, iohexol and iopromide, on renal function and survival in patients who underwent coronary angiography. A total of 14,141 cardiology patients from 2006 to 2013 were recruited, of whom 1,793 patients (679 patients on iohexol and 1,114 on iopromide) were evaluated for long-term renal impairment and 5,410 patients (1,679 patients on iohexol and 3,731 on iopromide) were admitted for survival analyses spanning as long as 15 years. Univariate and multivariate logistic regression were used to explore the risk factors for long-term renal impairment. Cox proportional hazard regression was used to investigate the risk factors affecting survival. Propensity score matching and inverse probability of treatment weighting were applied to balance the baseline clinical characteristics. Patients receiving iohexol demonstrated a greater occurrence of renal impairment compared with those who received iopromide. Such difference remained consistent both before and after propensity score matching or inverse probability of treatment weighting, with a statistical significance of p <0.05. Among clinical variables, receiving contrast-enhanced contrast tomography/magnetic resonance imaging during follow-up, antihypertensive medication usage, presence of proteinuria, and anemia were identified as risk factors for long-term renal impairment (p = 0.041, 0.049, 0.006, and 0.029, respectively). During survival analyses, the difference was insignificant after propensity score matching and inverse probability of treatment weighting. In conclusion, administration of iohexol was more likely to induce long-term renal impairment than iopromide, particularly among patients diagnosed with anemia and proteinuria and those taking antihypertensive medication and with additional contrast exposure. The all-cause mortality, however, showed no significant difference between iohexol and iopromide administration.
The invention discloses a process and a preparation method of fresh antler health-care wine. The components and the range of the mixture ratio by weight of traditional Chinese medicines used for infusing the health-care medicated wine are as follows: 1-5 parts of fresh antler, 1-6 parts of medlar, 1-6 parts of Chinese date, 1-8 parts of solomonseal, 1-6 parts of pawpaw, 2-10 parts of refined honey and 200 parts of white spirit. The preparation method comprises the following steps: after grouping the required medicinal materials, soaking by the white spirit respectively, squeezing, filtering, blending and ageing. The health-care wine is prepared by infusing with the white spirit which is brewed by rice distiller's yeast and has the alcoholic strength of 50 degrees, and has special taste. The health-care medicated wine has the effects of producing sperms, tonifying the marrow, supplementing qi, nourishing the blood, supplementing qi, moistening the lung, building the body, strengthening the body, nourishing the blood, supplementing yang and strengthening the bones and the muscles; the health-care medicated wine can promote and improve the microcirculation of the blood, acts as the functions of preventing and treating the diseases and is suitable for people of all ages. The invention has simple formula, good effect and higher use value and popularization value.
Prostate cancer has become the most frequent malignancy in older men in Western countries. Radiotherapy is a common treatment modality for early stage prostate cancer. Because of the high incidence of post-radiation erectile dysfunction (ED), up to 72% after external-beam radiotherapy, this patient category represents a most difficult therapeutic challenge. Oral drug therapy represents the first-line management option for patients with ED. The results of the studies completed thus far with sildenafil show that a phosphodiesterase type 5 inhibitor is a safe and efficacious drug for the treatment of post-radiation ED. No studies have investigated the efficacy of tadalafil in men complaining of ED after radiotherapy of prostate cancer. Because of the extended period of effectiveness, which may last up to 36 hours after intake, tadalafil allows freedom in the choice for time of sexual activity. Also the absence of restrictions of tadalafil intake with food or alcohol should simplify its administration. This randomized, double-blind, placebo-controlled, cross-over study has been designed to evaluate the efficacy and safety of "on demand" dosing of 20-mg of tadalafil or placebo administered for 12 weeks to patients with ED after external-beam radiotherapy for prostate cancer.
In controlled pharmacokinetic studies in elderly subjects (greater than 65 years) the clearance of oxycodone appeared to be slightly reduced. Compared to young adults, the plasma concentrations of oxycodone were increased approximately 15% 

(see PHARMACOKINETICS AND METABOLISM). Of the total number of subjects (445) in clinical studies of Oxycodone HCl Controlled-Release Tablets, 148 (33.3%) were age 65 and older (including those age 75 and older) while 40 (9.0%) were age 75 and older. In clinical trials with appropriate initiation of therapy and dose titration, no untoward or unexpected side effects were seen in the elderly patients who received Oxycodone HCl Controlled-Release Tablets. Thus, the usual doses and dosing intervals are appropriate for these patients. As with all opioids, the starting dose should be reduced to 1/3 to 1/2 of the usual dosage in debilitated, non-tolerant patients. Respiratory depression is the chief hazard in elderly or debilitated patients, usually following large initial doses in non-tolerant patients, or when opioids are given in conjunction with other agents that depress respiration.
Background: The chikungunya virus (CHIKV), transmitted by infected Aedes mosquitoes, has caused a significant number of infections worldwide. In Brazil, the emergence of the CHIKV-ECSA genotype in 2014 posed a major public health challenge due to its association with more severe symptoms. Objectives/Methods: This study aimed to shed new light on the host immune response by examining the whole-blood transcriptomic profile of both CHIKV-acute and chronically infected individuals from Feira de Santana, Bahia, Brazil, a region heavily affected by CHIKV, Dengue, and Zika virus epidemics. Results: Our data reveal complex symptomatology characterized by arthralgia and post-chikungunya neuropathy in individuals with chronic sequelae, particularly affecting women living in socially vulnerable situations. Analysis of gene modules suggests heightened metabolic processes, represented by an increase in NADH, COX5A, COA3, CYC1, and cap methylation in patients with acute disease. In contrast, individuals with chronic manifestations exhibit a distinct pattern of histone methylation, probably mediated by NCOA3 in the coactivation of different nuclear receptors, KMT2 genes, KDM3B and TET2, and with alterations in the immunological response, majorly led by IL-17RA, IL-6R, and STAT3 Th17 genes. Conclusion: Our results emphasize the complexity of CHIKV disease progression, demonstrating the heterogeneous gene expression and symptomatologic scenario across both acute and chronic phases. Moreover, the identification of specific gene modules associated with viral pathogenesis provides critical insights into the molecular mechanisms underlying these distinct clinical manifestations.
Patients with severe headaches often come to the emergency department seeking relief from their symptoms. There is some dating suggesting that over the counter treatment options are not inferior to treatment options offered in emergency departments. Patients presenting to the Einstein Emergency Department with IHS criteria for migraine headache will be approached by research associate and offered to participate in a randomized double blind study comparing excedrin migraine to compazine. Patients will be randomized by the hospital pharmacy. The pharmacy will distribute one of two packets, one containing prochlorperazine 10mg and 2 placebo tablets, the other containing 2 generic AAC tablets without scoring (acetaminophen 250mg, aspirin 250mg and caffeine 65mg in each tablet) and a placebo syringe. Patients will be monitored for improvement of pain, change in vital signs, and adverse events for two hours after receiving drugs. At 24 hours, the patients will be called back to access if they experienced any side effects from the time of discharge, and if they would take this medicine again if they experienced another migraine.
Together, breast cancer and type 2 diabetes represent a public health crisis. Approximately 20% of the 3.1 million breast cancer survivors in the U.S. have type 2 diabetes, and this number is expected to grow. Breast cancer survivors who have type 2 diabetes are at high risk for cancer recurrence, serious health complications, and premature death. Breast cancer survivors with type 2 diabetes experience more severe, disabling symptoms and psychological distress relative to breast cancer survivors without diabetes. For breast cancer survivors with type 2 diabetes, maintaining glycemic control is critical for decreasing symptoms and preventing serious health problems. Important diabetes self-management strategies include physical activity, dietary modifications, medication, and blood glucose monitoring. Many breast cancer survivors with type 2 diabetes have difficulty maintaining these behaviors and achieving glycemic control. Physical symptoms and psychological distress are often barriers to engaging in diabetes self-management. The proposed study evaluates a novel diabetes coping skills training (DCST) intervention for improving breast cancer survivors' abilities to manage symptoms and adhere to recommended diabetes self-management. The telephone-based DCST protocol is based on our prior work and integrates three key theory-based strategies: coping skills training for managing symptoms, adherence skills training, and healthy lifestyle skills training. The proposed randomized clinical trial (N=230) will test the effects of the DCST intervention by comparing it to diabetes education alone. Physical symptoms, psychological distress, diabetes self-management behaviors, and self-efficacy will be assessed at baseline and 3, 6, and 12 months. Physical activity will be assessed using wireless activity trackers and data will be obtained from home blood glucose monitoring devices. Glycosylated hemoglobin (HbA1c) will be assessed at baseline, 6, and 12 months. The proposed study addresses a critical gap in the care of breast cancer survivors by evaluating a novel behavioral intervention that aims to improve the management of symptoms, adherence, and glycemic control in breast cancer survivors with type 2 diabetes. The findings of this study could lead to significant improvements in clinical care and beneficial outcomes for breast cancer survivors.
The invention discloses a skin-nourishing anti-aging peony seed oil face mask and a manufacturing method thereof. The face mask is manufactured by using silk face mask paper to fully absorb a face masking liquid and sterilizing the obtained face mask. The face masking liquid is prepared from the following components: peony seed oil, sweet almond oil, an emulsifier, cananga odorata hydrosol, a chamomile extract, a yeast extract, an epidermis deep-penetration water-locking factor, an antiseptic and deionized water. The peony seed oil, sweet almond oil, chamomile extract, epidermis deep-penetration water-locking factor, and the like are mixed to form the face masking liquid having the function of locking water, moistening the skin and resisting oxidation. The face masking liquid containing peony seed oil and sweet almond oil matches the face mask paper for usage. The face mask paper tightly cover the skin to isolate the skin from the outside air and to make water slowly penetrate through the cuticle of the epidermis, thereby promoting the skin to absorb the face masking liquid, quickening the blood microcirculation deep in the skin and improving the activity of cells in each layer of the epidermis. The face mask can prevent water in the face mask from being quickly lost, and has the function of increasing the elasticity of the skin, tightening and lifting the skin, resisting wrinkles and aging, and diminishing inflammation and expelling toxin.
The invention discloses a traditional Chinese medicine composition for treating skin trauma and ulceration and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The paint comprises the following components in parts by weight: 5-7 parts of alum, 3-6 parts of camphor, 6-8 parts of borneol, 10-12 parts of rosin, 3-5 parts of common andrographis herb, 7-9 parts of oriental wormwood, 8-12 parts of gypsum, 4-6 parts of weeping forsythia capsule and 7-9 parts of red paeony root. The invention can stop bleeding of skin rupture and heal rapidly. Such as knife wound, gunshot wound, scratch, bruise, etc., and is applied in time to stop bleeding. It also has healing effect on skin ulcer caused by diabetes. The seal is quick, and bacteria can not enter the wound. The patient recovers quickly. The formulation ingeniously solves the problems of slow effect of the traditional Chinese medicine and great side effect of western medicines.
Aims/hypothesis: To compare glycemic metrics during pregnancy between women with type 1 diabetes (T1D) delivering large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) infants, and to identify predictors of LGA infants. Materials and Methods: A cohort study including 111 women with T1D using intermittently scanned continuous glucose monitoring from conception until delivery. Average sensor-derived metrics: mean glucose, time in range in pregnancy (TIRp), time above range in pregnancy, time below range in pregnancy, and coefficient of variation throughout pregnancy and in pregnancy intervals of 0-10, 11-21, 22-33, and 34-37 weeks were compared between women delivering LGA and AGA infants. Predictors of LGA infants were sought for. Infant growth was followed until 3 months postdelivery. Results: In total, 53% (n = 59) delivered LGA infants. Mean glucose decreased during pregnancy in both groups, with women delivering LGA infants having a 0.4 mmol/L higher mean glucose from 11-33 weeks (P = 0.01) compared with women delivering AGA infants. Mean TIRp >70% was obtained from 34 weeks in women delivering LGA infants and from 22-33 weeks in women delivering AGA infants. Independent predictors for delivering LGA infants were mean glucose throughout pregnancy and gestational weight gain. At 3 months postdelivery, infant weight was higher in infants born LGA compared with infants born AGA (6360 g ± 784 and 5988 ± 894, P = 0.04). Conclusions/interpretations: Women with T1D delivering LGA infants achieved glycemic targets later than women delivering AGA infants. Mean glucose and gestational weight gain were independent predictors for delivering LGA infants. Infants born LGA remained larger postdelivery compared with infants born AGA.
Forty matched non-diabetic patients with HbA1C ≤ 5.6%. They will not receive either treatment (metformin) or placebo.
Because of the strong evidence documenting symptom burden in PC survivors, the investigators believe that providing control subjects with some information about symptom self-management is warranted. The investigators further believe, based on the investigators' prior experience conducting RCTs, that offering some type of educational material for Veterans randomized to the control arm will increase their willingness to enroll in the study (as opposed to a pure usual care arm where they would not receive any such materials). Therefore, survivors randomized to the control condition will receive written material at the time of enrollment designed to educate them about PC symptoms and symptom management. Material will be approximately six pages in length, also written at or below an 8th grade reading level, and will include a summary of common symptoms experienced by prostate cancer survivors.
The invention provides a medicine composition for treating echinococcosis of animals. The composition is prepared from the following components in parts by weight: 15-45 parts of radix aconiti, 5-20 parts of przewalskia tangutica, 10-40 parts of rhododendron spanotrichum, 5-20 parts of fructus chebulae, 3-15 parts of acorus calamus, 2-15 parts of radix aucklandiae, 2-15 parts of synthetic musk, 2-15 parts of embelia laeta and 5-25 parts of safflower. The composition is natural in source, and is safe and environment-friendly. The invention further provides a tablet prepared from the composition and a preparation method thereof. The preparation method comprises the steps of pretreatment, grinding and crushing, granulating, tabletting and the like. The method is simple, is easy to implement, and can be used for improving the bioavailability of the medicine composition. The invention also provides application of the medicine composition in treatment of echinococcosis of animals.
Participants will receive Prochymal® consisting of 2 million hMSCs/kg actual body weight, intravenously (IV) on Days 1 and 4 along with daily standard of care which includes methylprednisolone 2 milligrams (mg)/kg IV or prednisone 2.5 mg/kg orally. Participants will also continue cyclosporine, tacrolimus, and/or mycophenolate mofetil (MMF) at full therapeutic doses.
The control group received conventional physical therapy, which consists of range of motion, stretching, resistance, and strengthening exercises. The CPT group had a conventional intervention of 24 sessions, lasting 4 days per week for a total of 6 weeks. The CPT group was given 48 minutes of conventional physical therapy sessions per day for weeks 1 and 2, followed by 80 minutes of conventional physical therapy sessions per day for the next 4 weeks. At a follow-up of two weeks, this group also received conventional physical therapy.
FIELD: medicine, stomatology. SUBSTANCE: method involves every day sanitation of mouth cavity, excluding local irritating factors and carrying out local medicinal treatment. A curative-prophylaxis dental paste is used as a local medicinal agent containing chalk, carboxymethylcellulose sodium, glycerol or sorbitol, lauryl sulfate sodium, antiseptic - preserving agent, vitamin E, perfume, dicalcium phosphate, perfume oil, sodium saccharate and water taken at the definite quantitative ratios. Paste is used for mouth cavity treatment in the morning, in the evening before sleep and after each eating. Before teeth cleansing paste is applied on gum for 4-6 min and cleansing is carried out for 3 min, not less. Method ensures to enhance curative effect, eliminate gum hemorrhages, cervix teeth hypersthesia and increase salivation. EFFECT: enhanced effectiveness of method. 1 cl
BACKGROUND: Patients with thick cutaneous pT4 malignant melanoma are at high risk for metastatic disease, and optimal staging is poorly defined. This study examines the frequency and modality of pre-operative staging to provoke thought on optimal staging.
METHODS: A retrospective study was performed of patients with clinical T4N0 melanoma diagnosed between 2015-2017. The modality (sentinel lymph node biopsy and/or imaging), timing, and findings of staging investigations were assessed.
RESULTS: One hundred thirty-six patients with pT4a or pT4b cutaneous melanoma and clinically negative regional lymph nodes were included. Forty patients underwent no staging. Thirty-six patients underwent pre-operative imaging, and of these, regional or distant disease was identified in seven patients (19%). Another 36 patients underwent upfront sentinel lymph node biopsy concurrently with wide local excision. A positive sentinel lymph node biopsy was found in eight (22%) of these patients, of which two had regional or distant metastatic disease on postoperative imaging. Of 16 who underwent a sentinel lymph node biopsy after negative pre-operative imaging, three had a positive sentinel lymph node biopsy.
CONCLUSION: Staging is non-standardized and underutilized in patients with thick melanoma. With evolving systemic treatment options, a well-defined approach to staging, with consideration for pre-operative imaging in pT4 patients, is essential for high-risk patients.
The invention which is named as "fritillary and snow pear particle and preparation method thereof" belongs to the technical field of composite traditional Chinese medicines. The fritillary and snow pear particle can mainly solve problems shown in the specification. The main characteristic of the fritillary and snow pear particle is that bulk drugs of a particulate agent (the particle) comprise 100-300 parts of a clear pear paste, 15-40 parts of Fritillaria cirrhosa, and 30-80 parts of Ophiopogon root. The preparation method comprises the following steps: preparing fresh pear into the clear pear paste with the relative density of 1.20-1.38; preparing Fritillaria cirrhosa into a percolate; decocting Ophiopogon root, lily, and tussilago, taking a supernatant, concentrating to a proper amount, adding the Fritillaria cirrhosa percolate and the clear pear paste, concentrating to a new clear paste (a stiff paste) with the relative density of 1.25-1.38; and preparing into the particle by taking 1-1.5 parts of the stiff paste, and adding 2-4.5 parts of sucrose, and 1-1.5 parts of dextrin. The fritillary and snow pear particle has the efficacies of lung moistening and cough relieving, and body fluid generating and throat disinhibiting. The particle of the present which has the characteristics of good cough relieving effect, accurate usage amount, and difficult bacterial contamination is mainly used in the fritillary and snow pear particulate agent for treating yin deficiency and lung heat, cough, tachypnea, and mouth and throat dryness and the preparation method of the particulate agent.
FIELD: medicine, juvenile hematology. SUBSTANCE: innovation deals with juvenile medicinal forms of a preparation for prophylaxis and treatment of hypochromic anemia of different etiology as a sanguification-stimulating preparation based upon ferric and cupric salts. The composition of carbohydrate foundation (toffee) to prepare such a preparation is additionally supplemented with ferric and cupric salts. Ferric salts counterbalance iron body deficiency, cupric ones stimulate sanguification processes. As protein additive it is necessary to use proteins of animal and plant origin. The innovation leads to increased efficiency and safety in application of curative-nutritive preparations for prophylaxis and treatment of hypochromic anemia. No reducing agent (vitamin C) prevents the activation of milk lipid peroxidation. EFFECT: higher efficiency. 4 cl, 10 ex
Recipients received a myeloablative conditioning regimen of cyclophosphamide (120 mg/kg total), fludarabine (125 mg/m2 total) and total body irradiation (1200 cGy with lung shielding to 600 cGy), followed by an infusion of a stem cell product selected for CD34+ progenitors using the Miltenyi CliniMACS® system. Older subjects will receive a lower dose of irradiation (800 or 600 cGy based on age) to reduce the regimen intensity.
Exercises will be completed in the Health Science Exercise lab. These will include stretching exercises, range of motion exercises, basic core-strength exercises, balance exercises, and relaxation techniques. Only bodyweight will be applied (i.e., no additional loading). This group controls for confounding variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation (Liu-Ambrose et al., 2010; Liu-Ambrose et al., 2012; Nagamatsu et al., 2012; Nagamatsu et al., 2013).