anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Rationale: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with endothelial damage and altered pulmonary microvascular perfusion. The molecular mechanisms underlying these changes are poorly understood in patients, in part because of the inaccessibility of the pulmonary vasculature. Peripheral blood mononuclear cells (PBMCs) interact with the pulmonary endothelium. Objectives: To test the association between gene expression in PBMCs and pulmonary microvascular perfusion in COPD. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited two independent samples of COPD cases and controls with ⩾10 pack-years of smoking history. In both samples, pulmonary microvascular blood flow, pulmonary microvascular blood volume, and mean transit time were assessed on contrast-enhanced magnetic resonance imaging, and PBMC gene expression was assessed by microarray. Additional replication was performed in a third sample with pulmonary microvascular blood volume measures on contrast-enhanced dual-energy computed tomography. Differential expression analyses were adjusted for age, gender, race/ethnicity, educational attainment, height, weight, smoking status, and pack-years of smoking. Results: The 79 participants in the discovery sample had a mean age of 69 ± 6 years, 44% were female, 25% were non-White, 34% were current smokers, and 66% had COPD. There were large PBMC gene expression signatures associated with pulmonary microvascular perfusion traits, with several replicated in the replication sets with magnetic resonance imaging (n = 47) or dual-energy contrast-enhanced computed tomography (n = 157) measures. Many of the identified genes are involved in inflammatory processes, including nuclear factor-κB and chemokine signaling pathways. Conclusions: PBMC gene expression in nuclear factor-κB, inflammatory, and chemokine signaling pathways was associated with pulmonary microvascular perfusion in COPD, potentially offering new targetable candidates for novel therapies.
OBJECTIVE: This study aims to compare intraoperative bleeding during liver transplant procedures and analyze the predictive role of preoperative laboratory indicators in significant intraoperative bleeding.
PATIENTS AND METHODS: A retrospective analysis was conducted on 271 cases of allogeneic liver transplant patients from January 2018 to June 2023. Patients were categorized into the massive bleeding (MB) group and the non-massive bleeding (non-MB) group based on the occurrence of significant intraoperative bleeding. Preoperative laboratory parameters between the MB and non-MB groups were compared, and univariate and multivariate regression analyses were performed. ROC curves were performed to analyze the value of these parameters in distinguishing the MB and non-MB groups.
RESULTS: In the MB group, body mass index (BMI), hemoglobin (Hb), platelet count (PLT), fibrinogen (Fib), and total protein (TP) levels were significantly lower than those in the non-MB group (p < 0.05). Conversely, prothrombin time (PT), international normalized ratio (INR), total bilirubin (TBIL), creatinine (CRE), blood urea nitrogen (BUN), the model for end-stage liver disease (MELD) score, length of stay, and hospital stay were significantly higher in the MB group compared to the non-MB group (p < 0.05). Univariate and multivariate logistic regression analyses revealed that preoperative BMI and Hb were independent risk factors for massive bleeding during liver transplantation. ROC curve analysis for predicting massive intraoperative bleeding showed that the area under the curve (AUC) of Hb was considerable (AUC: 0.83).
CONCLUSIONS: Preoperative BMI and Hb levels are critical predictors of massive bleeding during liver transplantation, emphasizing the importance of proactive management based on these indicators for improved patient outcomes.
PROBLEM TO BE SOLVED: To obtain a new compound useful as a precursor of perfume and/or antimicrobial agent or the like which is employed to prepare personal-care products laundry products, cleaning compositions and the like and stable in their preparation, transportation and storage. SOLUTION: This compound is represented by the formula [R<1> is an enolic residue of an aldehyde or a ketone; X is an (un)saturated bialent hydrocarbon residue including a 1-20C or the like; R<2> is an (un)saturated (substituted) carbocycle or the like; (n) is 0 or 1], e.g. methyl succinate undeca-1,9-dienylester. The compound represented by the formula is obtained, for example, by the procedure describedc in J. Chem. Soc., Paerkin Trans. I. 2509 (1993). The compound represented by the formula is cleaved by skin bacteria, enzymes, high temperature or the like and produces one or more functional and/or antimicrobial compounds and is therefore useful as a precursor of an odor masking agent and the like.
The use of closed-suction draining has been well studied in the hip and knee arthroplasty literature. Drains have been used with the intention of decreasing infection, ecchymoses, and frequency of dressing changes. Some have reported a corresponding decrease in hematocrit for patients receiving post-op drainage leading to increased transfusion needs. Given that no clinical benefit has been consistently documented regarding drain usage in knee and hip arthroplasty, they are no longer routinely used in those operations. The use of such drainage systems in shoulder arthroplasty, however, has not been studied and the benefit of drain use in regards to patient outcomes is questionable. As such, the study is a prospective investigation comparing outcomes in two groups of total shoulder arthroplasty patients, those receiving a drain at the time of surgery and those without a drain. The short-term outcome measurements include peri-operative hematocrit and hemoglobin, infection rate, hematoma development, transfusion requirement, ecchymosis and wound complication. Long-term outcomes include shoulder functional scores as measured by post-operative visits and any need for revision shoulder surgery.
Central nervous system disorders are currently being symptomatically treated since the molecular events provoking their onset have not been yet identified. Drug delivery techniques have to overcome the almost impermeable blood-brain barrier (BBB) and can be grouped into two main categories: (i) invasive and targeted, and (ii) non-invasive and non-targeted methods. However, the technological advances of the past decades revealed the immense potential of focused ultrasound (FUS) in transcranial applications. In contrast to other techniques, FUS-mediated BBB opening is both non-invasive and targeted. The localized energy delivery coupled with the circulation of intravenously administered microbubbles initiates biological effects confined only to the vessel walls and contained only in the targeted region within the brain.

The purpose of the study is to assess the safety and feasibility of focused ultrasound-induced blood-brain barrier opening in Alzheimer's disease patients, using a single-element transducer with neuronavigation guidance. The investigators will also test whether treatment with focused ultrasound alone alters the amyloid protein levels in the treated brain areas and its potential effects on the cognitive function of Alzheimer's patients.
Participants in the intervention group will get to participate in the SKY program, for 5 days with each day session taking 3 hours/day. SKY program involves a) specific breathing exercises and social interaction with other participants in the program. Following completion of the program, another set of questionnaires will be administered to collect information regarding stress, mood, and opioid use. After completion of the 5 day SKY program, participants will practice SKY every day at home for 30 days. They will also need to attend 4 weekly group sessions during this period and each session is expected to last 1 hour. At the end of the 30 day period, another set of questionnaires will be administered to collect information regarding stress, mood, and opioid use.
BACKGROUND Cystocerebral syndrome is delirium occurring in the elderly that results from urinary retention and acute bladder distension. Urinary retention can cause cerebral issues, such as altered mental status, without having an infection present. The pathophysiology is possibly due to increased catecholamine secretion while attempting to micturate. Due to its presenting symptoms, most physicians begin cerebrovascular workup, performing unnecessary and, often, invasive imaging studies. Although easily overlooked as a differential diagnosis, cystocerebral syndrome is an easily treatable cause of delirium and should be considered during treatment of elderly patients with delirium. CASE REPORT The patient was an 89-year-old man with a medical history of chronic obstructive airway disease, dementia, hypertensive disorder, and gastroesophageal reflux disease who presented with altered mental status secondary to urinary incontinence. The computed tomography scan without contrast showed a large volume of impacted stool in the cecum, with a distended urinary bladder. This case report describes his presentation, medical treatment, and outcome and discusses areas of gap improvement. CONCLUSIONS To date, there are only a handful of published articles on cystocerebral syndrome. This case report aims to add the awareness of bladder distention as an etiology of cystocerebral syndrome to the body of knowledge in the scientific community in the hope that patients will be identified and treated earlier, more safely, and at a reduced cost. Cystocerebral syndrome needs to be extensively addressed in research, and physicians should consider it one of the important differential diagnoses of delirium among elderly men.
The present invention relates to nucleic acid sequences encoding a 30 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 30 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host. Cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
Aims and objectives: During COVID-19 panic, we examined if educational digital video disk can reduce maternal uncertainty, anxiety and depression if their children undergo congenital heart disease surgery and when surgical or post-surgical complications occur.

Background: Mothers experience uncertainty, anxiety and depression if their children undergo conditions mentioned above. Such stress would be more during COVID-19 panic. Design: A randomized control-group pretest-posttest design. The CONSORT checklist is used. Methods: During COVID-19 panic, in a teaching hospital, 120 mothers whose children underwent first elective surgery for congenital heart disease were randomly divided into group 1: 60 mothers receiving routine education plus digital video disk before surgery; and group 2: 60 mothers receiving routine education. Between groups, mothers' uncertainty, anxiety and depression levels were compared (1) before education, (2) after education (before surgery) and (3) on the discharge day. Among mothers whose children had surgical or post-surgical complications, the effect of watching the digital video disk on uncertainty, anxiety and depression at discharge day was evaluated.
In the modern medical science, antibacterial, antiviral and anticancer therapies cause many side effects in infection diseases and show a significantly limited therapeutic effect. Therefore, there is a need for developing safe and highly effective antibacterial, antiviral and anticancer agents. The present inventors have conducted intensive studies for 4.5 years based on knowledge about medicines, combinations of medicinal herbs and foods and have performed various tests in terms of combinations, therapeutic effects and toxicity. As a result, significantly safe and excellent antibacterial, antiviral and anticancer agents have been developed. The antibacterial, antiviral and anticancer agent according to an embodiment includes a combination of 60% or garlic, 10% of ginger, 7% of chives, 5% of lotus roots and 18% of fig fruits. According to another embodiment, the agent includes a combination of 30% of Sasa borealis (Hack.) Makino, 10% of heartleaf houttuynia, 10% of Asian lizard′s tail, 3% of ginkgo leaves, 10% of Salvia plebeian, 7% of Ceramium kondoi, 5% of Ficus religiosa, 3% of Angelica gigas Nakai, 5% of adlay powder, 5% of Hedyotis diffusa Willdenow and 7% of lotus root powder. The agents are highly effective for treating diseases caused by bacteria and viruses. Particularly, the agents are highly effective for treating respiratory diseases, such as a cold and influenza, intestinal diseases, such as stomachache and diarrhea, cystitis, prostatitis, or the like. Considering a large world market of antibacterial, antiviral and anticancer agents, commercialization of the agents can promote national interests and can provide an effect of treating many patients.
Polymeric foam beads are prepd. by reacting vinylidne chloride (VDC) with an alpha, beta-ethylenically unsatd. silane to form a silane functional polymer in pellet or bead form, impregnating a volatile blowing agent into the polymer and exposing the polymer to heat to activate the blowing agent and expand the polymer to a cellular crosslinked structure. The polymer can also be used for films and coatings. The beads are used for making moulded foam articles of low density, thermal conductivity and vapour transmission and good resistance to chemicals and fire, e.g. for packaging or carpet padding.
PURPOSE:To prepare a healthy drink having mellow flavor and high-quality nutrients, by roasting unpolished granules of maize by a fire directly and quickly so that they are baked into a semiexpanded state. CONSTITUTION:Unpolished granules of carefully selected, and dried maize are washed and immersed in pure water or mineral water for about 3-5hr, and dehydrated. The prepared granules are immediately put in an automatic roaster, and roasted by a strong fire quickly into a semiexpanded state. The maize is ground in such a way that one granule is divided into 8-14 fractions to give a matter like green tea. If necessary, the style of the female flower of maize is washed separately, dried, cut into about 1-1.5cm, and roasted by a roaster by a low fire for a short time. The matter like tea may be blended with the prepared style in a proper ratio. The prepared healthy drink is used for drinking by a means such as direct decoction, extraction with warm water, soaking in cold water, etc.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to paediatrics, dermatology and oncology, and can be used for treating infantile haemangiomas (IH). That is ensured by daily monotherapy with peroral administration of propranolol. Every three months linear velocity of blood flow is recorded in bringing, haemangioma-feeding vessel (LVB-1) and in at least three intra-parenchymatous discharge vessels (LVB-2). Maximum value of LVB-2 (LVB-2 max) is selected. If the values of LVB-1 and LVB-2 are max, equal to or less than 8 cm/s, the dose of propranolol is reduced by no more than 3 mg/day weekly until it is withdrawn. Initial dose of propranolol can be determined by titration in range of 1 to 2.8 mg/kg/day for 6 days. Linear velocity of blood flow can be determined by ultrasonic examination of haemangioma with Doppler sonography.EFFECT: method enables higher clinical effectiveness IH by establishing objective criteria of clinical effectiveness in preventing recurrences and preventing by-effects caused by prolonged therapy.3 cl, 4 ex
A non-pressure continuous blood pressure measuring device, comprises: a radar sensing module, an electro-cardiac sensing module and a microprocessor. The radar sensing module includes at least a transmitter and a receiver, the transmitter continuously provides a pulse wave signal to an artery, the receiver receives a reflected pulse wave signal. The electro-cardiac sensing module includes at least an electrode; the electro-cardiac sensing module receives an electro-cardiac signal through the electrode. The microprocessor is in signal transmittable connection with the radar sensing module and the electro-cardiac sensing module. The microprocessor controls the radar sensing module and the electro-cardiac sensing module, and simultaneously receives the reflected pulse wave signal and the electro-cardiac signal. The microprocessor determines a blood pressure parameter of the artery according to the reflected pulse wave signal and the electrocardiography signal.
OBJECTIVES: The aim of this study was to evaluate the clinical profile and outcome of young infants presenting to the pediatric emergency department with hypernatremic dehydration.
METHODS: A prospective observational study was conducted at a tertiary care teaching hospital over a period of 18 months. All outborn sick young infants aged 2 months or younger who presented to the emergency department with symptoms and signs of possible sepsis and/or dehydration were screened, and those with hypernatremia were enrolled in the study. Those infants born at less than 37 weeks of gestation and gross congenital anomaly were excluded. Hypernatremic dehydration was defined as serum sodium levels (Se Na+)higher than 145 mEq/L. Variables used in the study were defined as per standard definitions. Acute kidney injury was defined and staged using serum creatinine as per modified neonatal Kidney Disease Improving Global Outcome guidelines. Clinical presentation, laboratory parameters, and comorbidities were compared among outcome groups (survived and died).
RESULTS: Of 1124 outborn young infants who met the eligibility criteria for screening, 63 were diagnosed to have hypernatremic dehydration and 55 were enrolled. The hospital-based period prevalence of hypernatremic dehydration in young infants was 4.89%. The median age of presentation was 17 days (10-30). Male-to-female ratio was 1.1:1. Seventy-three percent were first in birth order. Feeding pattern showed 61.8%, 30.9%, and 7.3% of infants were exclusively breastfed, top fed, and mixed fed, respectively. The median serum sodium at the time of admission was 160 (153.5-167) mg/dL. Three (5.5%) infants had mild, 39 (70.9%) had moderate, and 13 (23.6%) had severe hypernatremic dehydration. There was statistically significant correlation between median platelet count with severity of hypernatremic dehydration. The mean time taken to correct serum sodium level was 3.30 ± 1.60 days. The case fatality rate was 41.8%. Those who died had statistically more severe hypernatremic dehydration, acute kidney injury, sepsis, and need for ventilation.
CONCLUSIONS: Acute kidney injury stage 3, shock, and need for ventilation are associated with poor outcome in infants with hypernatremic dehydration.
The neurofeedback group will perform 6 training sessions over a period of 4 months: 4 fortnightly sessions in the first two months will be followed by 2 monthly 'booster' sessions. Each session will include several behavioural assessments and fMRI-based neurofeedback training in an MRI scanner (1 h). The neurofeedback training phase will be be followed-up by two behavioural assessments 8 and 12 months after the first training.
<P>PROBLEM TO BE SOLVED: To provide a method for forming uniform fine particles from a fragile material.  <P>SOLUTION: This improved method for forming fine particles from the material includes a step for dissolving the material in a solvent to form a dilute solution, a step for immobilizing the dilute solution, and a step for removing the solvent to yield particles of the material. The method for immobilizing the dilute solution includes freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat for activating a phase transition. Essentially, any material and a solvent for the material can be used in the provided method. Proteins and peptides in aqueous solvents are the preferred systems.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Antibiotic-associated diarrhoea (AAD) is a frequent condition in hospitalised patients receiving antibiotic treatment. The same is true for Clostridium difficile-associated diarrhoea (CDAD) with even more grave consequences of increased morbidity and mortality. The development and evaluation of preventive strategies is one key public health challenge. In the absence of clinically evaluated alternatives, probiotics have been suggested to be beneficial for the prevention of AAD and CDAD. However, data have so far been inconclusive and recently published meta-analyses strongly recommended large state-of-the-art clinical trials on probiotic substances for the prevention of AAD and CDAD. Since the efficacy, side-effects and modes of action of different probiotic bacteria and yeast are strain specific, benefits and risks cannot be generalised. The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD. We carry out a randomised, placebo controlled, double blind multicentre clinical trial to evaluate Sac. boulardii for the indication of prevention of AAD and CDAD in 1520 adult, hospitalised patients.
EXTRANEAL is intended for intraperitoneal administration only. Not for intravenous or intra-arterial administration. Administer as a single daily exchange for the long dwell in continuous ambulatory peritoneal dialysis or automated peritoneal dialysis. The recommended dwell time is 8 to 16 hours. Administer over a period of 10 to 20 minutes at a rate that is comfortable for the patient.

The mode of therapy, frequency of treatment, exchange volume, duration of dwell, and length of dialysis should be initiated and supervised by the prescribing physician experienced in the treatment of kidney failure in patients requiring long-term kidney replacement therapy with peritoneal dialysis. It is recommended that patients being placed on peritoneal dialysis should be appropriately trained in a program that is under supervision of a physician.