anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: To prevent post-partum haemorrhage (PPH), national and international guidelines recommend the administration of a prophylactic injection of oxytocin after all vaginal births. Although additional maintenance oxytocin is not recommended in the immediate postpartum, its administration is quite common (30 % of French births in 2021). To assess in a single center, the frequency and determinants associated with the administration of maintenance oxytocin in immediate postpartum.
STUDY DESIGN: A retrospective observational single-centre study was conducted in a tertiary-care university centre in Paris (France), with data from April-May 2022. All women who gave birth vaginally at or after 37 weeks, except for those with immediate PPH. Univariate and multivariate analysis were performed to compare determinants between the group receiving maintenance oxytocin and the control group without this intervention. A sensitivity analysis in a population of women at low risk of PPH was performed. Maternal, obstetrical, perinatal and organisational determinants were collected.
RESULTS: This study included 584 patients, 278 (47.6 %) of whom received maintenance oxytocin. We observed a significantly higher rate of maintenance oxytocin administration to parous women (OR 1.57, 90 %CI 1.09-2.27) and women with a history of PPH (OR 2.88, 90 %CI 1.08-9.08). Additional maintenance oxytocin was also administered more often when the midwife handling the birth had more than 5 years of practice since completion of training (OR 1.77, 1.24-2.53) or during night-time births (OR 1.47, 90 %CI 1.03-2.10).
CONCLUSION: Maintenance oxytocin administration is a frequent practice, performed for almost half the patients in our center. This practice is associated with maternal and obstetric factors, but also with health professionals' individual decisions and practices.
Structural systems and method are employed including a multiplicity of computers to control the acquisition and enhancement of skilled performance or behavior. Pre-processing computers (8 and 24) each accept signals from any corresponding one of a variety of physiological or other signal transducers either in close proximity to the computer or transmitted to the computer via a telemetering system. The pre-processing computer calculates a number of different measures of this signal and makes the results known to one or more other computers. These other or auxiliary computers control presentation of a display of the data for a human observer, and perform additional calculations which determine if the processed data is within a predetermined range. This range may be a function of time and/or other variables. A measure of the error between the allowed range and the processed data is computed within these auxiliary computers. These results may be used to alter the display. They are also returned to the pre-processing computer where they may alter the pre-processing calculations. Alteration of the display and the pre-processing calculations are adapted to improve skilled performance and behavior without the intervention of a human operator other than the user.
OBJECTIVE: Decision for intervention in acute subdural hematoma patients is based on a combination of clinical and radiographic factors. Age has been suggested as a factor to be strongly considered when interpreting midline shift (MLS) and hematoma volume data for assessing critical clinical severity during operative intervention decisions for acute subdural hematoma patients. The objective of this study was to demonstrate the use of an automated volumetric analysis tool to measure hematoma volume and MLS and quantify their relationship with age.
METHODS: A total of 1789 acute subdural hematoma patients were analyzed using qER-Quant software (Qure.ai, Mumbai, India) for MLS and hematoma volume measurements. Univariable and multivariable regressions analyzed association between MLS, hematoma volume, age, and MLS:hematoma volume ratio.
RESULTS: In comparison to young patients (≤ 70 years), old patients (>70 years) had significantly higher average hematoma volume (old: 62.2 mL vs. young 46.8 mL, P < 0.0001), lower average MLS (old: 6.6 mm vs. young: 7.4 mm, P = 0.025), and lower average MLS:hematoma volume ratio (old: 0.11 mm/mL vs. young 0.15 mm/mL, P < 0.0001). Young patients had an average of 1.5 mm greater MLS for a given hematoma volume in comparison to old patients. With increasing age, the ratio between MLS and hematoma volume significantly decreases (P = 0.0002).
CONCLUSIONS: Commercially available, automated, artificial intelligence (AI)-based tools may be used for obtaining quantitative radiographic measurement data in patients with acute subdural hematoma. Our quantitative results are consistent with the qualitative relationship previously established between age, hematoma volume, and MLS, which supports the validity of using AI-based tools for acute subdural hematoma volume estimation.
To separate the glycolipids from a lipid mixture containing complex lipids, the neutral lipids are separated, where appropriate, by chromatography on silica gel and the glycolipids are then separated from the phospholipids by chromatography on a boric acid gel. If appropriate, the gangliosides can be subsequently separated from the fraction containing the glycolipids by solvent in the presence of water. The fraction containing the glycolipids can be treated by ion exchange chromatography to separate the nonacidic glycolipids from acidic glycolipids. Similarly, the nonacidic phospholipids and the acidic phospholipids can be separated by ion exchange chromatography of the fraction containing the phospholipids. <??>The various fractions can be incorporated into dietary products, especially for infants, or into cosmetics or pharmaceuticals. 
[EP0365868A2]
To provide an oil-in-water type emulsion containing zinc oxide and having high stability.SOLUTION: There is provided an oil-in-water type emulsion containing zinc oxide-containing composite particles having a matrix and zinc oxide and a plurality of nonionic surfactants having different HLB values. The matrix contains a silicon oxide and a hydrocarbon group. The zinc oxide is dispersed in the matrix. The average HLB value of the plurality of nonionic surfactants is 8.0 to 13.0. The average HLB value is a value determined by the following expression (1). In the expression (1), Hx represents an HLB value of each nonionic surfactant and Wx represents a ratio of the mass of each nonionic surfactant to the total mass of the plurality of nonionic surfactants. Average HLB value=Σ(Hx×Wx)...(1)SELECTED DRAWING: None
Although the adverse effects of long-term use of vitamin K oral anticoagulant (OAC), warfarin, on the coronary vasculature are well-established, it remains unknown whether nonvitamin K oral anticoagulants play a role in the attenuation of plaque progression and coronary calcification. This study aimed to compare the changes in atherosclerotic plaques and calcification of the coronary arteries in patients with atrial fibrillation (AF) treated with edoxaban and warfarin. A total of 150 OAC-naïve patients with AF and atherosclerotic lesions on coronary computed tomography angiography (CCTA) were enrolled and randomly assigned to the edoxaban or warfarin treatment groups. All enrolled patients received rosuvastatin 10 mg and 119 patients completed the entire study protocol. A total of 12 months after the assigned OAC treatment, follow-up CCTA was performed and changes in plaque and calcium volumes of the coronary arteries were analyzed. The baseline characteristics of the 2 groups were well-balanced. The percentage of time in therapeutic range in the warfarin group was 61.1%. Compared with the baseline CCTA, there was a significant reduction in plaque volume after 12 months of OAC and rosuvastatin administration in both groups, and the extent of regression did not differ significantly between the groups. The increase in calcium volume was greater in the warfarin group than in the edoxaban group; however, the difference was not significant. In OAC-naïve patients with AF and atherosclerotic coronary lesions who were treated with moderate-intensity statin, edoxaban use did not have a positive effect on atherosclerotic plaques and coronary calcification compared with warfarin use over a 12-month follow-up period.
Joint lavage can be used in acute knee osteoarthritis, and can be repeated when it is effective. This procedure can generate pain and anxiety which are prevented by systematic prescription of analgesics and anxiolytics. To assess the benefit of hypnosis intervention, the investigators designed a monocentric prospective controlled randomised, single-blind study. Patients with acute and painful knee osteoarthritis, having an indication of lavage according to the rheumatologist, will be randomized to standard care, versus standard care and hypnosis. The hypothesis is that hypnosis intervention will decrease the level of pain during lavage, and the analgesics consumption during the week following the lavage. The sample size will be 100, 50 patients per group. Inclusion is scheduled for 18 months, and duration of the study will be 2 years. The main efficacy criterion is the pain score (assessed using VAS) difference between the 2groups; no interim analysis will be performed.
The Pelvic floor muscle training (PFMT) protocol based on National Institute for health and clinical excellence (NICE clinical guideline 40, 2006), that the PFMT programs should comprise at least eight contractions performed three times per day, and the trial of supervised PFMT of at least 3 months' duration . Each appointment the women maid three sets of eight to 12 slow maximal contractions sustained for 6-8 second, and asked to made this protocol every day, and taught to contract these muscle to suppress urge filling. Four visits in 3 months with pelvic floor physical therapist, who is trained in the procedure, for reinforced pelvic floor muscles.
Adult patients with pediatric onset short bowel syndrome (SBS) or intestinal failure (IF) have been described as a distinct population warranting further research. The aim of this exploratory study aimed was to offer initial insights into this population's navigation of childhood, adolescence, and transition into adulthood. Both quantitative and qualitative data were collected from a convenience sample of adults with pediatric-onset SBS/IF using a disease-specific pilot survey; 14 questionnaires were completed. Responses indicated childhood and adulthood were complex and marked by joys and trials, while adolescence was experienced by many as a particularly challenging time. As adults, numerous patients experienced barriers to accessing the medical care they desired and described difficulties finding experienced and knowledgeable providers who listened and offered individualized care. This study highlights the importance of further studying this unique patient population, suggesting it can offer critical insights to inform the development of interventions and transition programs.
The proposed study is a randomized controlled trial to determine whether intrastromal voriconazole improves outcomes in fungal keratitis. Patients presenting to the Aravind Eye Hospitals in Pondicherry, India for treatment of fungal keratitis will be recruited for the proposed study. Approximately 70 patients will be enrolled in the study. Subjects presenting with fungal keratitis will be randomized to receive topical natamycin plus intrastromal voriconazole or to receive topical natamycin alone. Subjects may also receive oral antifungals after day 3 at the discretion of the treating clinician. All study subjects will be followed for 3 months to evaluate response to treatment.

Investigators from the University of California, San Francisco (UCSF) will assist Aravind Eye Hospital with the study design, implementation, and analysis of the research, and will help fund the study. The investigators will visit Aravind to help with the study implementation. UCSF will play an important role in this study by assisting with the study design, implementation, analysis, and funding.
Children will participate in intensive leg training with a physical therapist 1 hour/day, 4 days/week for 12 weeks. Children will continue to receive standard physical therapy care. Children will be followed for one year from the time of enrollment in the study.
To determine if the addition of a contralateral routing of signal (CROS) microphone on the un-implanted ear improves performance. Baseline tests are completed with Advanced Bionics Naida Q70 or Q90 sound processors. Patients are then given the Phonak Naida Link CROS aid to test if there is a benefit.
455,027. Freezing sera &c. SHARP & DOHME, Inc., 640, North Broad Street, Philadelphia, U.S.A. Jan. 4, 1935, No. 352. Void [Abridged as open to inspection under Sect. 91 of the Acts, Aug. 1, 1935]. [Class 29] [See also Groups VI and XVII] Preparations of sera in the solid state and readily convertible into the liquid condition are obtained by rapidly freezing the fresh sera and removing water therefrom by means of a high vacuum. These preparations may be made in receptacles such as the bottle shown in the Figure which is fitted with a screw cap 4 having a perforation 5 serving to secure a rubber seal 3 which can be penetrated by a hollow needle for connection of the vacuum apparatus or for the admission of liquid into the sealed container.
In patients who progress from acute hepatitis B virus (HBV) infection to a chronic HBV (CHB) infection, CD8+ T cells fail to eliminate the virus and become impaired. A functional cure of CHB likely requires CD8+ T cell responses different from those induced by the infection. Here we report preclinical immunogenicity and efficacy of an HBV therapeutic vaccine that includes herpes simplex virus (HSV) glycoprotein D (gD), a checkpoint modifier of early T cell activation, that augments CD8+ T cell responses. The vaccine is based on a chimpanzee adenovirus serotype 6 (AdC6) vector, called AdC6-gDHBV2, which targets conserved and highly immunogenic regions of the viral polymerase and core antigens fused to HSV gD. The vaccine was tested with and without gD in mice for immunogenicity, and in an AAV8-1.3HBV vector model of antiviral efficacy. The vaccine encoding the HBV antigens within gD stimulates potent and broad CD8+ T cell responses. In a surrogate model of HBV infection, a single intramuscular injection achieved pronounced and sustained declines of circulating HBV DNA copies and HBV surface antigen; both inversely correlated with HBV-specific CD8+ T cell frequencies in spleen and liver.
The present invention relates to a medical pill for colon, which is used for treating chronic colitis. The medical pill for colon is prepared from Chinese herbal medicines as raw materials according to the dosage proportion: 3 to 12% of coptis, 4 to 11% of phellodendron bark, 8 to 13% of aurantii immaturus, 5 to 12% of prepared dried ginger, 8 to 13% of stir-baked rhizoma atractylodis macrocephalae with oil, 9 to 15% of curculigo rhizome, 11 to 25% of aucklandia root, 11 to 25% of magnolia bark and 3 to 7% of cinnamomum cassia. The medical pill for colon is mainly used for treating various kinds of colitis and has the effects for clearing heat, removing toxicity, warming the spleen, invigorating yang, relieving oppression, eliminating masses, coordinating dryness and dampness, relieving diarrhoea, etc. The medical pill for colon has the advantages of convenient administration, reliable therapeutic effect, little recurrence and no harmful toxic or side reaction, and the medical pill for colon is an ideal medicine for treating colitis at present. Through clinical verification, most of colitis patients treated by the medical pill for colon are not well by repeated treatment in other medical departments, get well or are cured by the general treatment for 1 to 3 courses according to different courses of diseases. By the statistics of 460 treated colitis patients from 1996 to 2002, the number of cured patients is 376 and accounts for 81.7%, the number of effective patients is 64 and accounts for 13.9%, the number of no effective patients is 20 and accounts for 4.4%, and total effective rate reaches 95.6%.
BACKGROUND AND AIM: G protein-coupled estrogen receptor (GPER) is an estrogen receptor located on the plasma membrane. We previously reported that the administration of G-1, a GPER-specific agonist, suppressed development of acute ovalbumin (OVA)-induced asthma in a mouse model. Herein, we evaluate the involvement of GPER in a mouse model of chronic OVA asthma.
METHODS: G-1 or saline was administered subcutaneously to BALB/c mice with chronic OVA asthma, and pathological and immunological evaluation was performed. In addition, Foxp3-expressing CD4-positive T-cells in the spleen and ILC2 in the lungs were measured using flow cytometry.
RESULTS: We observed a significant decrease in the number of inflammatory cells in the bronchoalveolar lavage fluid (BALF) in the G-1 treated group. In the airways, inflammatory cell accumulation, Th2 cytokines (IL-4, IL-5, IL-13, and eotaxin) and epithelial cytokine TSLP were suppressed, while in the BALF, anti-inflammatory cytokines (IL-10 and TGF-β) were increased. Furthermore, in splenic mononuclear cells, Foxp3-expressing CD4-positive T-cells were increased in the G-1 group, whereas treatment with G-1 did not change the percentage of ILC2 in the lungs.
CONCLUSION: G-1 administration suppressed allergic airway inflammation in mice with chronic OVA asthma. GPER may be a potential therapeutic target for chronic allergic asthma.
The invention relates to a hand-mouth baby wet tissue and a preparation method thereof. The hand-mouth baby wet tissue is composed of compound wet tissue liquid and non-woven fabrics for holding the compound wet tissue liquid, wherein every 100 parts of the compound wet tissue liquid comprises the following components in percent by weight: 0.01%-7.5% of a sweetening agent, 0.01-2.0% of a preservative, 0.01%-2.0% of a cleaning agent, 0.05%-5.0% of a solubilizer, 0-10.0% of a humectant, 0-5.0% of a skin care agent, 0-5.0% of an acidity regulator, 0-5.0% of essential oil, 0-5.0% of a stabilizer, 0-1.0% of natural essence, and the balance of pure water. The hand-mouth baby wet tissue has the advantages that edible sweetening agent is added into the compound wet tissue liquid to promote spittle secretion of babies, relieve the drop of pH value in the oral cavity and prevent the formation of decayed teeth. The product formula is stable and safe, and the material components are non-toxic. The formula is safe, non-irritant and non-corrosive, so that the allergic risks are reduced to be the lowest. The hand-mouth baby wet tissue can be used for cleaning the hands and mouths of an infant, infant tableware and other infant supplies and toys.
Provided are anti-wrinkle agents having a novel parent nucleus that are suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically permissible salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that occur as a result of photoaging due to ultraviolet ray exposure that is skin aging with increased age. [In the formula, R1 represents a hydrogen atom or a 1- to 8-carbon straight or branched alkyl group. R2 represents -SH, -SO3H, SSX1, SX2, SOX3, SO2X4, SO2NY1X5 or SO2NY2Y3. X1-X5 independently are hydrogen atoms or 1- to 8-carbon aliphatic hydrocarbon groups or 5- to 12-carbon aromatic parts wherein carbon atoms may be substituted with heteroatoms. Y1-Y3 independently represent hydrogen atoms or 1- to 8-carbon straight or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1- to 8-carbon straight or branched alkyl chain. R4 represents a 5- to 12-carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]
PROBLEM TO BE SOLVED: To automatically inform a user of a set schedule. SOLUTION: A memory (flash memory) 2 in which a schedule is written is inserted into a terminal casing 1 and the schedule is read out by an internal CPU. When it becomes time specified by the schedule, an alarm is generated from a speaker 6, the execution of the schedule is instructed and contents (in the case of a medical schedule, e.g. the sort of medicines to be taken and the quantities of medicines) to be executed are displayed on a display screen 3. When a release button 5 is depressed, the alarm is stopped, and when a case ejection button (not shown in the Figure 1) is depressed, a medicine case 10 is ejected from the casing 1 and a required medicine can be taken out in accordance with the displayed contents on the display screen 3.  When the case 10 is inserted into the casing 1, the displayed contents on the screen 3 are switched to the display of a time depiction and information indicating the execution of the schedule is written in the memory 2.
A calling device of a MRI system may include a reader/writer and a call maker. The reader/writer can send a fixed-frequency electromagnetic wave. The call maker may include a main body, an antenna, an operating member, and an answering controller. The antenna can generate an induced current after receiving the fixed-frequency electromagnetic wave. The operating member can switch between first and second positions relative to the main body. The answering controller is configured such that: when the operating member is in the first position, a first radio-frequency signal is sent through the antenna with energy obtained from the induced current generated by the antenna, and when the operating member is in the second position, a second radio-frequency signal is sent through the antenna with energy obtained from the induced current generated by the antenna. The reader/writer can send different prompt signals according to the first and second radio-frequency signals.
The present invention provides for the automatic generation of a series of significant images. One or more representative significant images are used to generate a pattern description. The pattern description can include any information useful to identify an object of interest, or pattern. The pattern description can include a mathematical shape definition of one or more patterns, a search boundary defining an image area to search for matching patterns, and one or more pattern characteristics. The pattern description is compared to one or more images and one or more amounts of match between the pattern description and each image is obtained. The amount(s) of match are then compared to one or more thresholds. If one or more of the amounts of match exceed one or more thresholds or are within an upper and lower threshold window, then the image is automatically selected for inclusion in a series of significant images.