anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
FIELD: forest chemistry, medicine. SUBSTANCE: invention relates to preparing active substances from fir wood greens. Method involves milling fir wood greens, saponification of lipids by treatment of milled raw with 5-10% alkali an aqueous solution at the room temperature. Then an organic solvent is added to composition of the formed emulsion at the volume ratio mixture : solvent = (1: 0.1)-(1:0.5) and then a mixture is treated by ultrasonic oscillation. Then neutral lipid substances are extracted from obtained emulsion by extraction with petroleum ether. EFFECT: increased yield of the end product. 11 ex
This study aimed to develop a quantitative analysis program of blood flow velocity by vessel diameter in neovascular age-related macular degeneration (nAMD) subjects using high-speed swept-source optical coherence tomography angiography. This retrospective, observational, cross-sectional study included 10 eyes of healthy volunteers and 4 eyes of patients with representative nAMD. Novel scan patterns and variable interscan time analysis were utilized to measure the flow parameter, a surrogate marker of blood flow velocity, by vessel diameter within different depths. Detected vessels at superficial and deep as well as outer retinal regions were categorized into three vessel diameters (major vessels (> 40 μm), medium vessels (20-40 μm), and capillaries (< 20 μm)). The flow parameter increased with enlarged vessel diameter in all participants at superficial and deep layer. All nAMD subjects, except for type 3 macular neovascularization (MNV), contained a structure dominated by medium vessels at outer retinal region. The mean flow parameter at outer retinal region was type 1 MNV (1.46 ms-1), type 1 + 2 MNV (0.98 ms-1), and polypoidal choroidal vasculopathy, including branching vascular networks (1.46 ms-1). This program provides the possibility to extract the blood flow information at different depths by vessel diameter types, which is considered to be useful tool for evaluating nAMD pathology and activity.
PURPOSE:To obtain elderberry tea useful for health promotion in a short time, by treating raw leaves of elderberry with a large amount of steam when the leaves are put in a steamer and steamed so that harshness in the leaves of elderberry is sufficiently removed as dark gray liquid. CONSTITUTION:Raw leaves of elderberry are put in a steamer, heated with steam until harshness in the leaves of elderberry is sufficiently removed as dark gray liquid, rubbed by a coarsely rubbing machine at 80-90 deg.C for 40-50min, further rubbed by a middle rubbing machine and dried by a drier to give elderberry tea. In the conventional method for using leaves of elderberry, raw leaves of elderberry are dried in the sun or in he shade to give dried leaves, which are decocted several tens minutes and decocted juice is used for drinking. The juice becomes muddy and emits an offensive odor. The elderberry tea can be produced from raw leaves in about 4hr and qualities are constant. Elderberry components are readily extracted simply by pouring hot water to the elderberry tea and an extracted solution neither causes change in quality nor emits offensive odor.
The invention discloses a turnip-fructus hippophae tablet and a preparation method and applications thereof. The turnip-fructus hippophae tablet mainly comprises ingredients including turnip powder and fructus hippophae extract at a mass ratio of (3-6):(5-9). The production technique comprises the steps of by taking turnip of BrassicarapaL. as an active ingredient, slicing, drying, grinding, sterilizing and the like to obtain turnip powder, extracting, drying, grinding and the like by taking fruits of HippophaerhamnoidesL.subsp.SinensisRousi. as an active ingredient to obtain the fructus hippophae extract, mixing the turnip powder and the fructus hippophae extract powder to prepare granules, tabletting and packaging to obtain the turnip-fructus hippophae tablet. The turnip-fructus hippophae tablet has the beneficial effects of being used for producing food, hypolipidemic health-care products and drugs, having the efficacy of treating hyperlipidemia and various atherosclerosis, being more obvious in efficacy compared with the single turnip tablet and the single fructus hippophae tablet, having no toxic and side effects, and being good in mouth feeling, low in cost, and convenient to produce.
The invention relates to a rose flower composition for improving the skin temperature, compound emulsion and applications thereof. The rose flower composition mainly comprises rose flowers, vitamin E, vitamin C, Chinese angelica, ligusticum wallichii, and spatholobus stem. The rose flower composition can be made into a plurality of dosage forms such as emulsion, tablets, dripping pills, sustained-release preparation, controlled-release preparation, and the like. Many people feel cold in limbs, especially females. Through high calorie diet, spicy food, water bath, cold-hot compress, exercise, and physical method such as electronic thermal therapy instrument, the symptom of coldness in limbs can be relieved, but the method mentioned above has the disadvantages of inconvenience and slow effect. The provided rose composition has the advantages of user-friendliness and practicality, and is capable of promoting blood circulation and increasing the skin temperature.
One of the consequences of breast cancer treatment for younger women is the abrupt onset of menopause and its related symptoms. Menopausal symptoms disrupt usual activities, alter sleep patterns and decrease quality of life. In light of the recent findings from the Women's Health Initiative (re:use of exogenous estrogen), the need to investigate non-hormonal approaches (meditation) for short-term menopausal symptom discomfort is high. The purpose of this randomized feasibility pilot study is to examine mindfulness meditation for menopausal symptom management for women who are breast cancer survivors and for women with naturally occurring menopause. The study is designed to: 1. establish the feasibility of a mindfulness meditation program for women who experience menopausal symptoms (e.g. hot flushes). 2. explore the treatment benefit of a mindfulness meditation program for menopausal symptom relief using changes in frequency and severity of hot flushes; frequency of sleep disruption, various aspects of quality of life and physiologic stress response (cortisol) as outcome measures. 3. evaluate whether the treatment benefits of mindfulness meditation differ in menopausal women with naturally occurring menopause versus women with menopause secondary to chemotherapy for breast cancer. A 2x2 factorial repeated design will be used. The four randomized groups will consist of 1) naturally occurring menopause meditation; 2) naturally occurring menopause attention control; 3) breast cancer survivors meditation; 4) breast cancer survivors attention. Participants randomized to the attention control group will be offered meditation training after completion of the intervention and follow up phases. Participants will attend 8 meditation sessions or 8 attention control sessions. Study variables are Menopausal Hot Flushes (self report \& skin conductance monitoring), Sleep Disruption (Pgh Sleep Quality Index), Physiologic Stress Response (cortisol), Quality of Life (Menopausal Quality of Life); and Protocol Design (recruitment \& retention rates, exit interviews). A convenience sample of 60 women who experience menopausal symptoms will be recruited. Data analysis includes descriptive statistics, repeated measures content analysis. Results from this feasibility pilot study will inform the design of a larger randomized clinical trial to test the effectiveness of mindfulness meditation as a self care intervention for menopausal symptom management and improvement in quality of life.
BACKGROUND Visual hallucinations occur in a variety of clinical settings and may be extremely troubling to individuals experiencing them. We report a case of delayed-onset visual hallucinations 20 years after initiation of medical therapy to highlight the importance of considering iatrogenic causes when managing such patients. CASE REPORT An 88-year-old woman presented with recurring hypnopompic formed visual hallucinations for the past 20 years. These hallucinations began 20 years after she was started on propranolol to treat her systemic hypertension 40 years earlier. Her hallucinations began with plants and insects. They later progressed to vivid, detailed human figures of different races, ages, genders, and religious personnel such as monks, nuns, and priests. The hallucinations occurred almost daily and upon awakening from sleep. Each episode of visual hallucinations lasted for 10 to 20 seconds, occurring when she awoke after dozing off, multiple times each day. The patient became mentally distressed by her visual hallucinations and began to attribute them to supernatural causes. After substituting her propranolol with atenolol, the patient's hallucinations decreased dramatically and became rare and non-frightening. The dramatic improvement suggested a drug-induced etiology. CONCLUSIONS Our case illustrates the importance of considering iatrogenic causes in the diagnosis of visual hallucinations and having a high index of suspicion, even if the onset of symptoms is delayed for many years after initiation of therapy. This iatrogenic condition can easily be rectified to drastically improve the quality of life in affected patients.
PURPOSE:To obtain a compound useful as an insecticide or repellent in powdery solid state having improved persistence and stability of the effect by clathrating diethyitoluamide with a multi-molecular host compound. CONSTITUTION:A clathrate compound is produced by using diethlyltoluamide as a guest compound and directly contacting and reacting the guest compound with a multi-molecular host compound capable of including the guest compound. The reaction is carried out at room temperature under stirring for about 5min. The clathrating ratio of diethyltoluamide to the multi-molecular host compound is preferably 10:90-90:10. The multi-molecular host compound is e.g., 4,4'- cyclohexylidene bisphenol bis(4-hydroxyphenyl)sulfone. Since the objective clathrate compound is powdery solid, it has excellent handleability and moldability and can be applied to various applications.
1,128,311. Molecular compounds of benzamides and aminobenzoates. MERCK & CO. Inc. 3 Jan., 1966 [11 Jan., 1965], No. 89/66. Heading C2C. [Also in Division A5] The invention relates to molecular compounds formed by combining 3,5-dinitrobenzamide or 2 - methyl - 3,5 - dinitrobenzamide with an equimolecular proportion of an aminobenzoic methyl ester of the formula in which R 2  denotes an alkyl, alkoxy or alkylthio group of 1-5 carbon atoms or a halogen atom and R 3  and R 4  each denote hydrogen or an alkyl group of 1-5 carbon atoms. The compounds are formed by bringing the components together in a solvent or by fusing a mixture of the components. In the solution method an excess of the aminobenzoic ester component may be used. Examples are given of the preparation of compounds from 3,5-dinitrobenzamide (or 2-methyl-3,5-dinitrobenzamide) and methyl 2-ethoxy-4-aminobenzoate. Other products of the invention are listed. The products are useful as additions to poultry feeds (see Division A5).
The invention discloses an aspirin-anticancer drug conjugate with a structure as shown in a formula (1) which is described in the specification. In the formula (1), A is originated from an anticancer drug capable of realizing acylation with the carboxyl group of aspirin. The invention discloses a preparation method for the aspirin-anticancer drug conjugate. The preparation method comprises a step of subjecting aspirin or an aspirin precursor compound and an anticancer drug to acylation in an organic solvent so as to prepare the aspirin-anticancer drug conjugate. The invention also discloses effect of the aspirin-anticancer drug conjugate in inhibition of proliferation of tumor cells. According to the invention, aspirin is coupled with a camptothecin drug or paclitaxel drug, so synergism of aspirin and the anticancer drug further improves inhibitory effect on tumor cells; and compared with the single anticancer drug, the aspirin-anticancer drug conjugate prepared in the invention has good synergism.
The study will involve an online screen of potentially eligible pregnant women. If participants are eligible after the online screen, they will be invited in for an in person assessment, including cognitive testing and a diagnostic interview, to determine eligibility. After the assessment, they will be informed of their eligibility status and, if applicable, randomized to Mindfulness Based Cognitive Therapy (MBCT) or treatment as usual (TAU). Participants in the MBCT group will complete 8 weekly, 2 hr group therapy sessions during pregnancy, as well as receive TAU. The TAU group will engage in regular care during pregnancy and be offered the option to attend one mindfulness psychoeducation session postpartum. Participants in the MBCT group will complete questionnaires prior to the 1st group session, after the 4th session, and after the 8th/final session. Participants in the TAU group will complete the same questionnaires at equivalent time points. All participants will come in for an in-person session at 34 weeks GA, during which they will complete questionnaires and a brief clinical interview. Participants will come in for an MRI scan session at 6 weeks postpartum. In addition to structural and functional MRI scanning, they will also complete questionnaires, a cognitive task, and brief psychiatric interview. At 6 months postpartum, participants will return for a visit, during which they will complete questionnaires, cognitive measures, and a clinical interview. This will be the final visit for women in the MBCT group. Women in the TAU group will complete a singe mindfulness psychoeducation session between 6 and 9 months postpartum; this must occur after their 6 month visit. Some visits will be adapted as needed to accommodate institutional requirements with regard to restrictions due to COVID-19.
BACKGROUND: Colleges and universities face an increased risk of public health emergencies. Among them, medical colleges and universities deserve more attention as they serve as the play a fundamental role in providing public health emergency services and in cultivating medical professionals. Effectively managing infectious disease prevention and control, as well as responding to public health emergencies in medical colleges and universities, is of great importance for enhancing the capacity of social emergency governance and improving the completeness of the public health system. This study aims to understand the management of public health emergencies in medical colleges in a city in southwest China, explore the factors associated with medical college students' evaluations, and provide recommendations for emergency management mechanisms in colleges and universities.
METHODS: In total, 781 medical college students were selected through stratified random sampling and surveyed using a questionnaire. The main factors affecting students' evaluation of emergency management were analyzed using multiple linear regression and structural equation modeling.
RESULTS: The overall emergency management situation in medical colleges was relatively complete, with satisfactory results. Medical college students' satisfaction with the timeliness of prevention measures was the highest, while the publicity and education were the lowest. Multiple linear regression analysis showed that grades, emergency education, -simulation training, -information reporting, and dynamic adjustment measures were associated with the evaluation of emergency management by medical students.
CONCLUSIONS: Although the evaluation of emergency management in medical colleges was generally positive, certain limitations still existed. To improve the development of the public health system, colleges and universities should constantly reform and innovate emergency management mechanisms according to the important links in the prevention and control processes.
During this study, participants will shop in an online store created using Shopify for four weeks. In this within-participant design, the first week of shopping is baseline. Participants will then be randomized to different store interfaces for the remaining three weeks based on one of two warning label conditions: 1) calorie labels (control); or 2) sugar graphic warning labels. Participants will complete a brief survey at the start of the study to assess demographic information, information about parent and child beverage consumption, and their online shopping experiences. At the end they will complete another survey about their beverage consumption, their experience shopping in the store, whether they noticed and used the warning labels, and their ability to recall the warning label message. Participants will also be asked about their perceptions of a specific type of warning label in this final survey. Upon completion of the survey, participants will be shown a debriefing statement explaining the study purpose. After they read the information, they will be asked whether or not they consent to allow their data to be used in this study.
Methylphenidate is a mild central nervous system stimulant.

The mode of action in man is not completely understood, but methylphenidate presumably activates the brain stem arousal system and cortex to produce its stimulant effect.

There is neither specific evidence which clearly establishes the mechanism whereby methylphenidate produces its mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system.

Methylphenidate hydrochloride in extended-release tablets is more slowly but as extensively absorbed as in the regular tablets. Bioavailability of the UCB methylphenidate hydrochloride extended-release tablet was compared to a sustained-release reference product and an immediate-release product. The extent of absorption for the three products was similar, and the rate of absorption of the two sustained-release products was not statistically different.  
In another reported study with a brand of Methylphenidate HCl sustained-release, the time to peak rate in children was reported as 4.7 hours (1.3 - 8.2 hours) for the sustained-release tablet dosage form and 1.9 hours (0.3 - 4.4 hours) for immediate release tablets. An average of 67% of a sustained-release tablet dosage form was excreted in children compared to 86% in adults.

In a clinical study involving adult subjects who received Extended-release (ER) tablets, plasma concentrations of methylphenidate hydrochloride’s major metabolite appeared to be greater in females than in males. No gender differences were observed for methylphenidate hydrochloride’s plasma concentration in the same subjects.
Dihydroergotamine binds with high affinity to 5-HT 1Dα and 5-HT 1Dβ receptors. It also binds with high affinity to serotonin 5-HT 1A, 5-HT 2A, and 5-HT 2Creceptors, noradrenaline α 2A, α 2Band α 1receptors, and dopamine D 2Land D 3receptors. 

The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT 1Dreceptors. Two current theories have been proposed to explain the efficacy of 5-HT 1Dreceptor agonists in migraine. One theory suggests that activation of 5-HT 1Dreceptors located on intracranial blood vessels, including those on arteriovenous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache. The alternative hypothesis suggests that activation of 5-HT 1Dreceptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. 

In addition, dihydroergotamine possesses oxytocic properties.
Women assigned to the sexual counseling group based on the PLISSIT model will receive four sessions in total, once a week. Each session consisted of an average of 30 min. Sessions will be conducted online as individual counselling sessions. The Plissit model was used based on a four-stage approach. These stages are (P-Permission): Permission, (Ll- Limited Information), providing limited information (SS-Specific Suggestions): Giving specific suggestions, (IT- Intensive Therapy): Intensive Therapy. In this study, the first three stages of the model will be applied. After the first three stages of the model are implemented, women with ongoing sexual problems are referred to specialized sexual therapists for intensive treatment/therapy.
Methods and systems for facilitating obtaining products and/or services using non-financial transactions over a financial transaction network are provided. Example embodiments provide a Single Swipe Obtainment System, which initiates providing requested product(s) in response to a non-financial transaction via a financial network. A non-financial entity supplies a card to each user. Items may be subsequently ordered by a user swiping the card in a point-of-sale device and entering a code associated with the requested item. When the code is received via the financial network by the non-financial entity, a product or service associated with the code is determined and supplied to the user, such as by shipping the associated product or service to the user. This abstract is provided to comply with rules requiring an abstract, and it is submitted with the intention that it will not be used to interpret or limit the scope or meaning of the claims.
Compared to the large armamentarium of antidiabetic agents for Type 2 Diabetes Mellitus (T2DM), the insulinocentric therapeutic approach in Type 1 Diabetes Mellitus (T1DM) has distracted the scientific perspective from the rise of novel therapies. Insulin monotherapy has long overshadowed the overall hormonal dysregulation that demarcates T1DM . In specific, the significance of the gut-derived incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic peptide), which are implicated with glucose metabolism via the gut-pancreatic axis, has been merely addressed.

Investigators' goal in the current protocol is to delineate the glucoregulatory role of incretin hormones in T1DM and the therapeutic advantages of adjunct metformin treatment over insulin monotherapy. In the absence of such knowledge, the development of effective strategies to improve metabolic homeostasis and ameliorate complications in T1DM patients will remain problematic. The central hypothesis of the study is that metformin, as an incretin-secretagogue, will enhance postprandial incretin secretion in T1DM patients, which will be reflected in reduced glucagon secretion and improvement in glycemic volatility. Mechanistic insight will be provided through changes in specific amino acids and metabolites patterns, chronic inflammation and the microbiome composition.