anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This will be a randomized clinical trial examining whether a personality feedback intervention can improve three outcomes in an online sample of adults with cancer: 1) self-awareness, 2) self-efficacy for managing aspects of their illness, and 3) mood. The study will occur in a single 30-minute online session conducted in Qualtrics, with a pre-post randomized design. Participants will respond to a baseline survey including a measurement of the Five-Factor Personality Model and measures of the 3 outcomes of interest, followed by random assignment to either an intervention group or control group. Both groups will read a brief description of the Five-Factor Model of Personality. Those randomized to the intervention group will also receive an individualized feedback report containing their personality results on each of the five personality factors and recommendations for cancer self-management based on these results. After reading the personality information, participants will respond to the outcome measures again in a post-intervention survey. Control participants will receive their individualized personality feedback reports after the study is complete.
Several premature aging mouse models have been developed to study aging and identify interventions that can delay age-related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging. Here, we analyzed DNA methylation in multiple tissues of four previously reported mouse models of premature aging (Ercc1, LAKI, Polg, and Xpg). We estimated DNA methylation (DNAm) age of these samples using the Horvath clock. The most pronounced increase in DNAm age could be observed in Ercc1 mice, a strain which exhibits a deficit in DNA nucleotide excision repair. Similarly, we detected an increase in epigenetic age in fibroblasts isolated from patients with progeroid syndromes associated with mutations in DNA excision repair genes. These findings highlight that mouse models with deficiencies in DNA repair, unlike other premature aging models, display accelerated epigenetic age, suggesting a strong connection between DNA damage and epigenetic dysregulation during aging.
In obese subjects, hepcidin concentrations are increased and iron absorption is believed to be reduced, leading to iron deficiency over time. How all this will influence iron supply of the fetus in obese pregnancy has not been well investigated to date. Even if maternal and fetal iron uptakes are regulated separately, it is unclear to what extent maternal subclinical inflammation might influence this process. A small study by Dao et al. indicated that maternal-fetal iron transfer was impaired in obese pregnant women, possibly due to hepcidin up-regulation. In this study, both maternal BMI as well as hepcidin were negatively correlated with cord blood iron status. Maternal hepcidin and c-reactive protein were significantly higher and cord blood iron was significantly lower in the obese compared to the normal weight. Hepcidin was shown to have an effect on iron transfer across the placenta in the study by Young et al.: the transfer was increased in women with undetectable hepcidin at delivery compared to those with higher levels. As of now, clear associations between maternal BMI or maternal hepcidin concentration and fetal iron status were not shown.
In this arm the subjects were provided with a PROTEIN drink to consume after exercise. This protein drink contained whey protein isolate that provided 0.3 g/ kg body mass of protein.
PURPOSE: To prevent repeatedly permanent-waved fibers from degeneration through such steps that a carboxylic acid-contg. acidic material is applied to a keratinous material which is then rinsed, placed under mechanical tension, subjected to a thiol-contg. reducing composition, then rinsed again, subjected to an oxidizing composition, rinsed further again, and separated from the tension. CONSTITUTION: This process includes the following steps: an acidic composition containing a carboxylic acid (salt) and adjusted to pH 2.5-7 is applied to a keratinous material which is then rinsed, and mechanical tension is applied to the keratinous material thus rinsed before, during or after the application of the acidic composition; subsequently, a thiol-contg. reducing composition is applied to the resultant keratinous material followed by rinsing it again and then applying an oxidizing composition to the keratinous material thus rinsed, and the resultant keratinous material is further rinsed again, and then separated from the tension. The carboxylic acid mentioned above is pref. citric acid.
Plantar fasciitis is a chronic, self-limiting, and painful disabling condition affecting the inferomedial aspect of the heel, usually extending toward the metatarsophalangeal joints. There is compelling evidence for a strong correlation between Achilles tendon (AT) loading and plantar aponeurosis (PA) tension. In line with this, tightness of the AT is found in almost 80% of patients affected by plantar fasciitis. A positive correlation has also been reported between gastrocnemius-soleus tightness and heel pain severity in this condition. Despite its high prevalence, the exact etiology and pathological mechanisms underlying plantar heel pain remain unclear. Therefore, the aim of the present paper is to discuss the anatomical and biomechanical substrates of plantar fasciitis with special emphasis on the emerging, though largely neglected, fascial system. In particular, the relationship between the fascia, triceps surae muscle, AT, and PA will be analyzed. We then proceed to discuss how structural and biomechanical alterations of the muscle-tendon-fascia complex due to muscle overuse or injury can create the conditions for the onset of PA pathology. A deeper knowledge of the possible molecular mechanisms underpinning changes in the mechanical properties of the fascial system in response to altered loading and/or muscle contraction could help healthcare professionals and clinicians refine nonoperative treatment strategies and rehabilitation protocols for plantar fasciitis.
To assure safe and effective use of benzodiazepines, the following information and instructions should be communicated to the patient when appropriate: 

  1. Inform your physician about any alcohol consumption and medicine you are now taking, especially blood pressure medication and antibiotics, including drugs you buy without a prescription. Alcohol has an increased effect when consumed with benzodiazepines; therefore, caution should be exercised regarding simultaneous ingestion of alcohol during benzodiazepine treatment. 
  2. Inform your physician if you are pregnant or are planning to become pregnant. 
  3. Inform your physician if you are nursing. 
  4. Patients should be informed of the pharmacological effects of midazolam, such as sedation and amnesia, which in some patients may be profound. The decision as to when patients who have received injectable midazolam, particularly on an outpatient basis, may again engage in activities requiring complete mental alertness, operate hazardous machinery, or drive a motor vehicle must be individualized. 
  5. Patients receiving continuous infusion of midazolam in critical care settings over an extended period of time, may experience symptoms of withdrawal following abrupt discontinuation. 
  6. Effect of anesthetic and sedation drugs on early brain development studies conducted in young animals and children suggest repeated or prolonged use of general anesthetic or sedation drugs in children younger than 3 years may have negative effects on their developing brains. Discuss with parents and caregivers the benefits, risks, and timing and duration of surgery or procedures requiring anesthetic and sedation drugs.
Participants will be assigned to a study group and dose level of ADI-PEG20 based on when participant join this study. Up to 2 dose levels of ADI-PEG20 may be tested. Up to 15 participants will be enrolled per dose level.
High-dose Melphalan 200 mg/m2/day IV over 30 minutes on day -2. SCT Day 0.
Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in neurodegenerative and cognitive disorders. While some evidence links the KP to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), further studies are needed to clarify the overall picture of how inflammation-driven KP disturbances may contribute to symptomology in ME/CFS. Here, we report that plasma levels of most bioactive KP metabolites differed significantly between ME/CFS patients and healthy controls in a manner consistent with their known contribution to symptomology in other neurological disorders. Importantly, we found that enhanced production of the first KP metabolite, kynurenine (KYN), correlated with symptom severity, highlighting the relationship between inflammation, KP dysregulation, and ME/CFS symptomology. Other significant changes in the KP included lower levels of the downstream KP metabolites 3-HK, 3-HAA, QUIN, and PIC that could negatively impact cellular energetics. We also rationalized KP dysregulation to changes in the expression of inflammatory cytokines and, for the first time, assessed levels of the iron (Fe)-regulating hormone hepcidin that is also inflammation-responsive. Levels of hepcidin in ME/CFS decreased nearly by half, which might reflect systemic low Fe levels or possibly ongoing hypoxia. We next performed a proteomics screen to survey for other significant differences in protein expression in ME/CFS. Interestingly, out of the seven most significantly modulated proteins in ME/CFS patient plasma, 5 proteins have roles in maintaining gut health, which considering the new appreciation of how gut microbiome and health modulates systemic KP could highlight a new explanation of symptomology in ME/CFS patients and potential new prognostic biomarker/s and/or treatment avenues.
According to one aspect, systems and processes for updating an alert rule are provided. In an exemplary process, one or more alert rules are displayed. A first user selection of a displayed alert rule is received, and in response, an alert modification interface corresponding to the selected alert rule is displayed. The alert modification interface may include one or more conditions for triggering a communication of an alert to an entity. At least one additional user selection indicative of a change to the one or more displayed conditions is received, where the conditions are for triggering the communication of an alert to an entity. In response to receiving the at least one additional user selection, the selected alert rule is updated.
Participants will receive MK-4250 600 mg tablet by mouth on Day 1 after an 8-hour fast. The decision to enroll Panel B and the dose selected (i.e., ≤600 mg) will be made based on evaluation of pharmacokinetics and 7-day safety and viral load data from Panel A.
FIELD: medicine, surgery. SUBSTANCE: during laparoscopy a free strand of omentum is fastened to peritoneum followed by aponeurosis dissection along 3-4 cm of center line from a trocar. Then omentum strand is isolated and fixed to aponeurosis in subcutaneous-fatty fiber. As a transplant it is necessary to use beta-cells culture of fetal pancreas in rabbits which is introduced into omentum strand by punctures. Method deals with creating a depot of pancreas islet cells cultures in greater omentum strand to have possibility to repeat introduction of beta-cells. EFFECT: higher efficiency to avoid traumatic laparotomic access and carrying out immunosuppressive therapy that leads to decreased requirements in exogenous insulin.
The intervention arm (use of PLGS feature) will utilize Tandem Diabetes Care's ambulatory insulin infusion pump with integrated Dexcom G5 CGM and predictive low glucose suspend function. This pump is called the "t:slim X2 with Basal-IQ Technology" and is referred to in the protocol as the Tandem PLGS pump.
The field of nuclear medicine has expanded rapidly since its inception in the mid-20th century, with nuclear medicine technologists now potentially experiencing higher levels of radiation exposure relative to other medical worker populations. Many radiopharmaceuticals and procedures used in previous decades are now obsolete and are being replaced by new and emerging radioisotopes and combined-modality and molecular imaging procedures. While improvements in imaging technologies and the introduction of certain radioisotopes have generally reduced patient exposure to radiation, nuclear medicine technologists have become increasingly specialized in these newer procedures and are performing these and other nuclear medicine procedures with increasing frequency. Furthermore, lead aprons are less effective in protecting workers during nuclear medicine procedures, specifically higher-energy procedures (e.g., positron emission tomography (PET)), compared to other radiation-related procedures, and are seldom used by technologists performing nuclear medicine. As a result, cumulative doses to nuclear medicine technologists are expected to have increased. We hypothesize that certified nuclear medicine technologists may experience higher risks of some radiation-related cancers and other adverse health outcomes compared to most other medical specialty groups. There is currently very little information about radiation-related risks associated with performing these procedures due, in part, to limited information on occupational doses associated with current nuclear medicine practices. To characterize organ-specific doses that could later be used to quantify risks for specific radiation-related disease outcomes, either directly (through subsequent follow-up) or indirectly (through risk projection methods), we plan to collect detailed work history information on nuclear medicine procedures and associated radiation safety practices, as well as badge doses, for a representative sample of 1,500 technologists certified in nuclear medicine in the U.S. This information will complement similar data collected in 2013-2014 from an independent sample of approximately 4,500 general radiologic technologists in the U.S. Radiologic Technologists Study (USRT) who had reported working with these procedures. However, unlike the USRT sample, the proposed sample is expected to be higher-risk, including only those workers with a specialty certification in nuclear medicine who will have been begun working with nuclear medicine procedures much earlier in their career, at ages associated with greater susceptibility to radiation-related carcinogenesis.
Desmoid tumors are rare tumors with a tendency to infiltrate locally. The lack of a standard treatment approach makes choosing the most appropriate treatment for patients challenging. Most experts recommend watchful observation for asymptomatic patients as spontaneous regression of tumor is observed in up to 20% of patients. Upfront resection of the desmoid tumor has fallen out of favor due to high morbidity and high relapse rates associated with the tumor. Systemic therapy has evolved over several decades. Where chemotherapy, hormonal therapy, and non-steroidal anti-inflammatory drugs were used over the last several decades, tyrosine kinase inhibitors came to the forefront within the last decade. Most recently, gamma-secretase inhibitors have shown significant clinical benefit in patients with desmoid tumors, bringing forth an entirely new mechanistic approach. Several Wnt pathway inhibitors are also under development. Invasive approaches like cryoablation have also shown clinical benefit in patients with extra-abdominal desmoid tumors in recent years. The recent approval of nirogacestat has ushered in a new era of treatment for patients diagnosed with desmoid tumors. Several new molecules are expected to be approved over the coming years.
PURPOSE:The titled food containing powder of Ostrea gigas Thunb. and/or extracted essence of Ostrea gigas Thunb. as an essential component. CONSTITUTION:A food for beautiful face and beautiful hair for preventing stain, etc., containing powder of the whole parts or part of Ostrea gigas Thunb. and/or extracted essence of Ostrea gigas Thunb. as an essential component. Chapped skin on the epidermic cells of the skin, an inflammation such as stain, etc., and fatigue phenomena of hair are essentially caused by metabolic abnormality of cell or by reduction in cell activity, reduction in water retention properties of epidermis, a cause of chapped skin, an increase in tyrosinase activity, a cause of strain result from reduction in cell activating ability from macroscopic view points. The food acts from the inner part of cell and increases the cell activity on the skin surface by internal use, increases and improves the cell activity and the cell activation themselves from the interior of human body not by remedy and cure from the skin surface.
Participants randomized to the control arm will participate in organized health workshops. Each session will last 60 minutes and will be offered on location and virtually (e.g., Zoom) over 6 months. Participants will meet once a week for the first 4 weeks, biweekly for 3 months, and once a month for the last 2 months for a total of 12 sessions.
Endotracheal intubation with DCI video laryngoscope:The group in which Dr.Halil Cebeci applied endotracheal intubation using a DCI video laryngoscope(Karl Storz GmbH \&Co. KG, Tuttlingen, Germany) consisted of 15 patients.Endotracheal intubation was performed by two practitioners using two different devices. Intubation times, number of attempts, failed attempts, postoperative complications and hemodynamic responses were recorded.
OBJECTIVES: Choir conductors represent a profession with an intensive vocal load. The present study aims to investigate the impact of 40 minutes vocal loading tasks on fundamental frequency (F0), jitter (Jitt), shimmer (Shim), median cepstral peak prominence (CPPs), and CPPs standard deviation in specific acoustic conditions.
METHOD: Eighteen amateur choir conductors (13 female, five male) participated in the study. The vocal loading experiment was organized in rooms where each conductor usually had choir rehearsals. The vocal loading experiment included vocal warm-up, singing, and loud reading. The STIPA test signal provided the background noise with 60 dBA @ 1m during the singing and reading tasks. The F0, Jitt, Shim, CPPs, and CPPs SD were extracted before and after vocal loading by the Vocal Holter Med (VHM) device. Additionally, Acoustic Voice Quality Index (AVQI) was estimated for participants, and all of them completed the Voice Handicap Index-30 (VHI-30) and the Singing Voice Handicap Index (SVHI). Finally, reverberation time (T30) was measured in each rehearsal room.
RESULTS: A statistically significant decrease of CPPs SD by 0.1 dB was observed in male conductors. Associations between CPPs SD and VHI-30 (r = 0.789, P = 0.001) were found in female conductors, and between Jitt and SVHI (r = 0.9, P = 0.037) in male conductors. Female conductors with higher total score of SVHI demonstrated increase of postloading F0 (r = 0.612, P = 0.026).
CONCLUSIONS: Forty-minute vocal loading tasks that included warm-up, intensive singing, and loud reading did not significantly impact vocal parameters in female and male conductors. In addition, the rehearsal room volume and length of reverberation time did not affect obtained vocal parameters after vocal loading.
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide, which is partly contributed to the increasing prevalence of COPD owning to a demographic shift towards an older population. Conversely, recent studies on COPD mortality that take this demographic shift in age into account find decreasing overall age-standardised COPD mortality rates over time. This decrease in the age-standardised COPD mortality rate is contributed advances in COPD diagnostics and treatment, decreasing smoking prevalence and general advances in medical care particularly in western countries. However, it is unknown if patients with COPD have experienced a comparable relative increase in survival in line with the general population.Hence, there is a need for longitudinal studies comparing trends in mortality in patients with COPD compared with matched non-COPD individuals from the background population.
METHODS AND ANALYSES: This is a cohort study with a matched non-COPD comparator cohort. Data are retrieved from the Danish national registers. Data from multiple registries from 1983 to 2018 will be merged on an individual level using the 10-digit Civil Registration numbers that are unique to each citizen in Denmark. Time trends in mortality in patients with COPD compared with the matched comparator cohort will be examined in three study periods: 1983-1993, 1994-2007 and 2008-2018.
ETHICS AND DISSEMINATION: The study is entirely based on registry data and ethical approval is not required according to Danish Law and National Ethics Committee Guidelines. The results will be published in peer-reviewed journals and reported at appropriate national and international conferences.
Group (2): Patients will be treated with QOD Max ® keratin hair treatment. It will be applied once with use of a flat iron.
The present invention relates to an ethanolic extract and a fucoidan extract from Sargassum fluitans, an algae found in Caribbean urine, which have hepatoprotective properties. Likewise, the invention refers to the different metabolites found in this alga. Active compounds or metabolites were identified by HPLC. Additionally, the invention demonstrates that the extracts have hepatoprotective properties since they were tested in vivo, in animal models where hepatic fibrosis was induced. The extracts were shown to be useful in protecting liver cells from external agents that induce liver damage such as CCl4. Likewise, the elaboration of a pharmaceutical composition for the prevention or hepatic protection in patients in need thereof is described. The ethanolic extract has anti-inflammatory and hepatoprotective activity that was demonstrated in vivo. These results allow establishing a new phytopharmaceutical with hepatoprotective properties.
<P>PROBLEM TO BE SOLVED: To provide a molecule for inhibiting an NgR1-mediated growth cone collapse and a neurite outgrowth inhibition resulted from the collapse and a method therefor.  <P>SOLUTION: The Sp35 polypeptide, the fusion protein thereof, the Sp35 antibody, the antigen binding fragment and the nucleic acid encoding them are provided. The composition containing the Sp35 antibody, the antigen-binding fragment, the Sp35 polypeptide and the fusion protein thereof is provided. The method for producing the Sp35 antibody, the antigen-binding fragment, the Sp35 polypeptide and the fusion protein thereof are provided. The use method thereof is provided.  <P>COPYRIGHT: (C)2010,JPO&INPIT