anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
gpD protein, the major subunit of the Duffy blood group antigenic system, has been isolated gpD protein contains the receptor, by which P. vivax enters red cells and causes malaria. gpD has significant sequence homology with human and rabbit interleukin-8 receptors and, therefore, gpD protein likely is a new class of chemoattractant cytokines receptor. gpD protein cDNA has a quasi-total homology with a human hippocampus cDNA clone HHCMF86 and, therefore, gpD protein or a homologous protein may be present as a neuropeptide receptor in brain. gpD protein is present in all red cell progenitors and it may be a receptor for cell proliferation and/or differentiation. gpD protein cDNA identifies in human kidney an mRNA of the same size as the bone marrow. Since the kidney is not and has no potential to become an erythropoietic organ, this putative chemoattractant receptor may have essential renal functions. gpD protein has therapeutic value in the prevention of malaria and in the regulation of erythrocythe, neural and renal functions and can be combined with physiologically acceptable diluents to yield a therapeutic agent suitable for these purposes. Peptides corresponding to a portion of gpD protein that contains the receptor also have been synthesized. Such peptides have therapeutic usefulness identical to that of gpD protein. gpD protein and such peptides also have utility in the production of therapeutics, e.g., antibodies, complementary peptides. etc., which are also useful to treat malaria and regulate essential erythrocyte, neural and renal functions.
In a system for monitoring and assessing subject response to programmed physical training, a client application provides an intake form, into which subject information, such as contact information, demographics and history may be entered. At least part of the subject information may be stored in a central repository for aggregation with other subject data, for analysis and reporting. Parameterized descriptions of exercises produce a binary string for each exercise, the resulting in a binary map of an entire exercise system, such as the PILATES system. Using a digital session planner, a practitioner selects from filtered lists of exercises to generate a customized exercise sequence for a subject. After the training session, the binary strings for the session are aggregated and a summary of the session displayed for user and/or practitioner. Session data may be uploaded to the repository for aggregation with data from other subjects/session for analysis and reporting.
The invention relates to a method for the production of a medicinal tincture and a medicinal tincture for external and internal use used to fight against slow healing inflammations and/or chronic inflammations.  The aim of the invention is to produce an effective medicament which accelerates the healing process of external and internal inflammations and wounds.  Said medicament must have an antibacterial effect and should have a skin-forming effect and help with circulation. It should be economical to produce, easy to store and simple to use.  According to the invention, ripe spores of the fruit body of Langermannia gigantea are mixed with diluted ethanol and are extracted in a darkened manner at temperatures of between 20 - 25 °C after three to six weeks.  Subsequently, the liquid is decanted.
Based on the TWML, we hypothesize that a large drop in reinforcement rate at the start of treatment with extinction alone or with FCT will increase the probability of an extinction burst. Preventing such drops will lessen the probability of an extinction burst. We will test the effects of eliminating reinforcement in the extinction-only condition and the effects of substantially decreasing the rate of reinforcement in the rate-drop condition. We will compare these two suboptimal treatments with one in which we ensure that the rate of reinforcement remains equal to baseline, called the rate-hold condition, which the TWML predicts will prevent an extinction burst.We will equate reinforcement magnitude (i.e., each reinforcer delivery will be 20 s) and quality (i.e., the functional reinforcer identified during the functional analysis) across the baseline and the rate-drop and rate-hold conditions (no reinforcement will be delivered in the extinction-only condition).
The purpose of this project is to widely disseminate a system of yoga tools to university students, faculty, and staff internationally to buffer the psychological impact of the COVID-19 pandemic. A recent study finds that stress, anxiety, and depression are the major psychological responses to COVID-19 during the early outbreaks in China (Wang et al., 2020). Globally, universities have closed campuses and moved learning, teaching, and working online with a very short notice. CDC suggests that keeping physically active and meditation are among the key activities to maintain a strong immune system and mental health during quarantine. Studies have documented physical and mental benefits of yoga practices (Balasubramaniam, Telles, \& Doraiswamy, 2013; Brems, 2015; Brunner, Abramovitch, \& Etherton, 2017; Büssing, Michalsen, Telles, Sherman, \& Khalsa, 2012) This project introduces a system of yoga tools to buffer the psychological impact of COVID-19. This system of yoga tools is designed by Sadhguru Jaggi Vasudev, a yogi, mystic, author, and founder of the Isha Foundation. The Isha foundation is a volunteer-based international non-profit organization, offering yoga and meditation programs for human wellbeing and global harmony. In partnership with the Isha Foundation and Harvard University Medical School, the study will document the short-term and long-term effects of these yogic practices on stress, mood, wellbeing, resilience, and academic engagement for students and work engagement for faculty and staff during this challenging time.
PURPOSE: To obtain a bathing composition having safe and excellent bathing effect without giving bad effect to a bathtub or a bath furnace and combinedly containing specific crude drug extracts. CONSTITUTION: Perilla extract is mixed with glycyrrhiza extract and aloe extract, and the resultant mixture is contained in a bathing agent in an amount of 0.1-20wt.%. A mixing ratio of the extracts is 1 pt. of glycyrrhiza extract to about 0.1-20 pts. of aloe extract and about 0.1-20 pts. of perilla extract, preferably 1 pt. to 1-10 pts. each. Furthermore, the mixture is suitably added with inorganic salts and usual bathing agent components and can be prepared for a tablet, granules, powder, a liquid agent, etc. In a case of a composition mixed with inorganic salts, the composition is preferably made to a solid agent such as powder.
Regional anesthesia is frequently used in adults and children as part of multimodal analgesia or as a direct anesthesia method. Nowadays, these regional blocks can be applied more safely with the widespread use of ultrasound in daily clinical practice. Also, by identifying individual variations with ultrasound, the risk of block failure and possible complications has been minimized. Femoral nerve block and pericapsular nerve group block are now almost the first techniques used in hip and lower extremity surgeries or different indications. (1) Besides, these methods have become more advantageous in many aspects compared to spinal anesthesia in high-risk patients. However, to apply safe and successful regional anesthesia, both gross anatomy and sonoanatomy of the relevant region must be known well.

There are sufficient clinical and anatomical studies on these anesthesia methods applied in the inguinal region in adults, and there is no anatomical and anthropometric study in children. (2,3) However, well-known anatomic reference points for performing these blocks in adults may be different in children. (4) Therefore, with this study, we planned to develop appropriate anatomic reference points for these blocks in children by evaluating the relationship between sonography and inguinal region structures (such as distance, diameter measurement) in children's age groups.
The present invention relates to a controlled-release drug delivery system for oral administration and a composition for forming a controlled-release porous membrane employed in the system. The controlled-release drug delivery system for oral administration of the present invention comprises a core containing a pharmaceutically active ingredient; and a controlled-release porous membrane coated on the outer surface of the core comprising at least one film formation material selected from the group consisting of a cellulose based compound, polymethacrylate, an acetate based compound, polyamide, polyurethane and sulfonated polystyrene. The controlled-release drug delivery system for oral administration according to the present invention can provide an effective and consistent drug release in gastrointestinal tracts because the release rate of the drugs can be controlled. Also, the timing of drug release can be controlled by varying the thickness of the porous membrane, composition of the membrane material, amount of the plasticizer and amount of the vehicles. And, preparation of the controlled-release formulation becomes simple and cost-effective because a small amount of the porous membrane is coated on a conventional tablet or granule. In addition, since the membrane is highly stable, a controlled-release formulation for oral administration not affected by temperature or humidity can be produced in large quantities.
BACKGROUND: The Achilles tendon is the body's strongest and largest tendon. It is commonly injured, particularly among athletes, accounting for a significant portion of serious tendon injuries. Several factors play a precipitating role in increasing the risk of these injuries.
OBJECTIVE: Our objective is to derive and validate a risk calculator for the prediction of incidence of any complication following Achilles tendon repair.
METHODS: We used de-identified data from the American College of Surgeons' National Surgical Quality Improvement Project (NSQIP) database from 2005 to 2021. It comprises 7010 individuals who had undergone Achilles tendon rupture repair. Demographic and risk factors information was collected. To develop the calculator, the sample was divided into a derivation cohort (40%) and a validation cohort (60%). Multivariate logistic regression was used for statistical analysis, and a risk calculator for incidence of any complication was derived from the derivation cohort and validated on the remaining 60% of the sample. Patients with missing data were excluded, and the significance level was set at p < 0.05.
RESULTS: We analyzed the derivation cohort of 2245 individuals who underwent Achilles tendon repair surgery between 2005 and 2021, with a 5.5% overall complication. Multivariate logistic regression identified anesthesia type, ASA classification, certain co-morbidities (pre-operative dialysis and medication-requiring hypertension), and wound classification as significant predictors of complications. The developed risk calculator model had an area under the curve (AUC) of 0.685 in the derivation cohort and 0.655 in the validation cohort, surpassing the widely used and validated modified frailty index. A cut-off score threshold of 0.06 was established using Youden's index to dichotomize individuals into low and high risk for developing any postoperative complications.
CONCLUSION: Our risk calculator includes factors that most significantly affect the incidence of any complication following Achilles tendon repair.
Patients who meet inclusion criteria may be randomized to micafungin dosed as 150mg intravenously every 24 hours according to local dosing guidelines. Duration will be managed by the primary team.
PURPOSE: A medical moving picture system and a storage method are provided to store medical moving pictures repeatedly offered according to a medical activity on the spot. CONSTITUTION: The system comprises a moving picture capturing module, and a record module. The moving picture capturing module captures moving pictures of medical processes, and transmits moving picture signals to the record module. The record module includes a capture card, a CD record device, a CPU, a main memory, a display, and an input device. The capture card converts the analog moving picture signals into digital signals. The CD record device records the digital signals at the CD in real time. The CPU controls an operation of each component. The main memory stores application softwares and an operating system. The input device inputs data on the recorded moving picture.
The present invention relates to a pure traditional Chinese drug capsule for treating hyperthyroidism and simple goiter. The present invention provides a pure traditional Chinese drug preparation for a patient suffering from hyperthyroidism and simple goiter. The preparation is prepared by 16 kinds of traditional Chinese drug materials, such as radix paeoniae alba, radix astragali seu hedysari, pangolin, etc. In the preparation technology, firstly, animal drug decoction pieces are mixed and pulverized into a fine powder drug, and then other vegetable drug decoction pieces are decocted three times to concentrate filter liquor into thick paste. Fine powder drugs are added in the thick paste and are evenly stirred to make soft drugs, and finally, the soft drugs are sieved, granulated, dried, shaped and capsulized. The traditional Chinese drug preparation has the advantages of novel formula, complementary drug effect, simple and convenient preparation technology, low production cost and convenient administration and has an obvious therapeutic effect on hyperthyroidism and a simple thyroid disease.
OBJECTIVE: Multiple scores validate long-term type-2 diabetes mellitus (T2DM) remission after metabolic and bariatric surgery (MBS). However, studies comparing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) have not adequately controlled for certain parameters, which may influence procedure selection.
METHODS: We conducted a multicenter retrospective review of patients with T2DM who underwent RYGB or SG between 2008 and 2017. Data on demographics, clinical, laboratory, and metabolic values were collected annually for up to 14 years. Each eligible RYGB patient was individually matched to an eligible SG patient based on diabetes severity, weight loss, and follow-up duration.
RESULTS: Among 1149 T2DM patients, 467 were eligible for matching. We found 97 matched pairs who underwent RYGB or SG. RYGB showed significantly higher T2DM remission rates (46.4%) compared to SG (33.0%) after matching. SG patients had higher insulin usage (35.1%) than RYGB patients (20.6%). RYGB patients also experienced greater decreases in HbA1c levels and diabetes medication usage than SG patients.
CONCLUSIONS: RYGB demonstrates higher efficacy for T2DM remission compared to SG, regardless of baseline characteristics, T2DM severity, weight loss, and follow-up duration. Further studies are needed to understand the long-term metabolic effects of MBS and the underlying pathophysiology of T2DM remission after MBS.
Participants will receive 1 spray of placebo solution in each nostril, 4 times with 10 minutes interval between each repeated sprays (total dose: 112 mg). Single 0.25-mg oral dose of triazolam will be administered 5 minutes before the first intranasal spray of placebo solution.
Autologous T-cell-based therapies, such as chimeric antigen receptor (CAR) T-cell therapy, exhibit low success rates in chronic lymphocytic leukemia (CLL) and correlate with a dysfunctional T-cell phenotype observed in patients. Despite various proposed mechanisms of T-cell dysfunction in CLL, the specific CLL-derived factors responsible remain unidentified. This study aimed to investigate the mechanisms through which CLL cells suppress CAR T-cell activation and function. We found that CLL-derived T cells get activated, albeit in a delayed fashion, and specifically that restimulation of CAR T cells in the presence of CLL cells causes impaired cytokine production and reduced proliferation. Notably, coculture of T cells with CD40-activated CLL cells did not lead to T-cell dysfunction, and this required direct cell contact between the CD40-stimulated CLL cells and T cells. Inhibition of kinases involved in the CD40 signaling cascade revealed that the Spare Respiratory Capacity (SRC) kinase inhibitor dasatinib prevented rescue of T-cell function independent of CD40-mediated increased levels of costimulatory and adhesion ligands on CLL cells. Transcriptome profiling of CD40-stimulated CLL cells with or without dasatinib identified widespread differential gene expression. Selecting for surface receptor genes revealed CD40-mediated downregulation of the Sialic acid-binding Ig-like lectin 10 (Siglec-10) ligands CD24 and CD52, which was prevented by dasatinib, suggesting a role for these ligands in functional T-cell suppression in CLL. Indeed, blocking CD24 and/or CD52 markedly reduced CAR T-cell dysfunction upon coculture with resting CLL cells. These results demonstrated that T cells derived from CLL patients can be reinvigorated by manipulating CLL-T-cell interactions. Targeting CD24- and CD52-mediated CLL-T-cell interaction could be a promising therapeutic strategy to enhance T-cell function in CLL.
JTX-8064 in combination with pimivalimab. Cohort will enroll subjects with advanced/metastatic PD-(L)1-naïve, platinum-resistant ovarian cancer.
Stroke is the major cause of disability and mortality worldwide. A stroke is defined as an abrupt neurological outburst caused by impaired perfusion through the blood vessels to the brain. Every year the number of patients affected by stroke is rising thereby putting extra pressure on socioeconomic conditions in developing countries. Major complications of stroke include hemiplegia leading to upper limb dysfunction along with gait abnormalities. This study will be conducted to determine the effects of proprioceptive neuromuscular facilitation exercises versus dual-task training on balance, cognition, and motor function in chronic stroke patients. The randomized clinical trial will be conducted, participants will be selected through Non-probability convenience sampling technique and then randomly allocated into two treatment groups.
In the intervention group, patients and/or companions are asked to provide visual material, which could consist of photographs of loved ones and/or places known to the patient. 30 minutes after the extubation of the patients, the CAM-ICU scale is administered, recording its value as R0. At night, the projection of images provided by the patient are replaced by a nocturnal visual projection (night sky with stars and moon), ensuring that the patient is able to identify that it was nighttime. Finally, at 9:00 a.m., a nurse who had not worked at night and therefore did not know which patients had received the intervention, administers the CAM-ICU scale again, recording its value as R1.
The invention relates to the extraction process of the celery extracts that have the antioxidant and vascular protective effect. The extracts from the stems and leaves of selected celeries, including Leaf celery (Apium graveolens variety secalinum), Honewort (Cryptotaenia Canadensis), and Celeriac (Apium graveolens var. rapaceum), commonly available in the market, are used for the experiments of antioxidation and vascular protection. The results show that the leaves of all three kinds of celeries contain the antioxidant and vascular protective effect. Among them, the Leaf celery has the best result, especially when the extracts of fresh leaf juice and the median concentration level (50-70%) of ethanol extracts are used. Comparison of the effect from using different parts of the Leaf celery indicates that the antioxidant and vascular protective effect from using the stems is less than that from using the leaves. Therefore, further experiments prove that the ethanol extracts of the celery can lessen the damages caused by Hcy and H2O2 and protect the artery.
The investigators will enroll 200 people in jail or within 12 months post-release from incarceration. During the trial, half of participants will be randomized into a control group that will receive usual care consistent with the setting in which they live, along with referrals customized to their needs and preferences to share with a case manager. They will be compared to the other half of participants randomized to the intervention group that, in addition to receiving customized referral sources, will also receive the GeoPassport App, incentives, and the support of a trained Peer Mentor for six months. The GeoPassport App will provide participants with tools for tracking goals and progress toward meeting them, assistance in locating services, appointment and medication reminders, opportunities to provide feedback on service providers, and built-in tracking and distribution of rewards (incentives) for service utilization. GeoPassport will assist Peer Mentors in monitoring participants' service utilization. The Peer Mentors will provide encouragement, role modeling, accompaniment to appointments, and assistance with goal setting, problem-solving, and reducing logistical and psychosocial barriers to service engagement. The intervention can be delivered in person or remotely in order to comply with necessary social distancing during the COVID-19 pandemic. Participants in both groups will be followed to assess whether those offered the intervention are more likely to meet the specific prevention targets described in the Specific Aims. The intervention lasts 6 months from the start of participation. Participants are interviewed at 3, 6, and 9 months from the same point as the intervention.
The spinous processes of T1- T5 will be identified and at parasagittal plan at 2.5 cm, skin wheel will be raised using 1% lidocaine. A 20-gauge, bevel needle will be advanced until the transverse process is located. The depth from skin to transverse process will be marked/identified by needle marking. The needle will be withdrawn 1-2 cm and angled down.The needle will be re-advanced 1cm past the initial marking. After negative aspiration, 4-5 ml of 0.25% bupivacaine will be slowly injected. The same procedure will be repeated at each level from T2 to T6 ensuring total dose of bupivacaine does not exceed the maximum dose recommended.
OBJECTIVE: To present the ultrasound imaging and genetic diagnosis of a fetus with prenatal lethal form of Gaucher disease.
CASE REPORT: A 37-year-old primiparous woman was pregnant at her 23 weeks of gestation and the prenatal fetal ultrasound revealed hydrops fetalis, cerebellum hypoplasia, and fetal immobility. The pregnancy was terminated due to major fetal anomaly, and whole exome sequencing (WES) analysis of fetal tissue and parental blood unveiled a pathogenic variant in exon 10 of the GBA gene (NM_001005741.3: c.1265T > G: p.L422R) originating from the mother. Additionally, a novel CNV (chr1: 155204785-155205635 deletion, 0.85 kb) spanning exon 10-12 in the GBA gene was identified from the father. This compound heterozygosity confirmed the diagnosis of prenatal lethal form of Gaucher disease and was informative for genetic counseling.
CONCLUSION: WES is a powerful tool to detect pathogenic variants among fetuses with nonimmune hydrops fetalis and complex abnormality from prenatal ultrasound. Compound heterozygosity consisted of single nucleotide variants (SNV) and copy number variations (CNVs) may lead rare inherited metabolic disorders including prenatal lethal form of Gaucher disease.
Testing by applying noninvasive positive pressure ventilation (NPPV) via two different bilevel positive airway pressure (BiPAP) devices . Arm two applies the Drager V-500, then the Respironics V-60.