anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The association between epidural analgesia and increased maternal intrapartum temperature has been well documented in multiple randomized controlled trials. The exact mechanism for this elevation in temperature is unknown; however the most likely cause appears to be non-infectious inflammatory stimulation. Fetal exposure to maternal fever in utero has been linked with increased antibiotic treatment, increased neonatal sepsis evaluation, and longer length of stay for neonates. In addition there is evidence to suggest intrapartum fevers may lower the threshold for fetal hypoxic brain injury and increase the risk of cerebral palsy. The risk of neonatal encephalopathy in infants born to febrile mothers is 1% compared to 0.1% to afebrile mothers. Safe interventions are needed to prevent adverse fetal outcomes.
AIMS: Parkinsonian tremor (PT) is regulated by numerous neurophysiological components across multiple temporospatial scales. The dynamics of tremor fluctuation are thus highly complex. This study aimed to explore the effects of different medications on tremor complexity, and how the underlying factors contribute to such tremor complexity.
METHODS: In this study, 66 participants received a 2-mg dose of benzhexol or a pre-determined dose of levodopa at two study visits in a randomized order. Before and after taking the medications, tremor fluctuation was recorded using surface electromyography electrodes and accelerometers in resting, posture, and weighting conditions with and without a concurrent cognitive task. Tremor complexity was quantified using multiscale entropy.
RESULTS: Tremor complexity in resting (p = 0.002) and postural condition (p < 0.0001) was lower when participants were performing a cognitive task compared to a task-free condition. After taking levodopa and benzhexol, participants had increased (p = 0.02-0.03) and decreased (p = 0.03) tremor complexity compared to pre-medication state, respectively. Tremor complexity and its changes as induced by medications were significantly correlated with clinical ratings and their changes (β = -0.23 to -0.39; p = 0.002-0.04), respectively.
CONCLUSION: Tremor complexity may be a promising marker to capture the pathophysiology underlying the development of PT, aiding the characterization of the effects medications have on PT regulation.
Training a generator includes processing a dental image using the generator to obtain a synthetic pathology label, such has a pixel mask indicating portions of the dental image representing caries. The synthetic pathology label is compared to a target pathology label for the dental image and the generator is updated according to the comparison. The synthetic pathology may be evaluated by a discriminator along with a real pathology label to obtain a realism estimate. The discriminator and generator may be updated according to accuracy of the realism estimate. Inputs to the generator may further include tooth labels and/or labels of restorations. Machine learning models may be trained to label restorations and defects in restorations. A machine learning model may be trained to identify the surface of a tooth having a pathology thereon.
All recipients in this arm received Venetoclax, Homoharringtonine and Cytarabine. Venetoclax was uesd as 100 mg on day 1, 200 mg on day 2, 400mg from day-3 to day-28. Homoharringtonine was uesd as 1 mg/m2 qd from day-1 to day-5. Cytarabine was uesd as 100 mg/m2 qd from day-1 to day-5.
The primary research question of the proposed study is this: Is a combination water-based physical exercise + cognitive training program for older Veterans with amnestic Mild Cognitive Impairment (MCI) feasible? The primary aims of the proposed research are: 1) demonstrate adequate recruitment and retention rates; 2) refinement of inclusion/exclusion criteria; and 3) further refine the combination waterbased physical exercise + cognitive training (WATER+CT) intervention.

These aims will be tested in a two-phase clinical trial with a single group design: 1) exercise training phase and 2) a cognitive training phase. The exercise training phase consists of a water-based physical exercise program that emphasizes cardiovascular fitness and strength training through a combination of non-weight bearing exercises that include land-based stretching and water-based activities. This 2-year pilot project will include 50 Veterans diagnosed with amnestic MCI age 50-90. The exercise component consists of a six-month water-based exercise program followed by a four-week cognitive training program. For the first two months of the water-based exercise program, Veterans will come to thrice-weekly group sessions at Aquatic Therapy Center at the VA Palo Alto Health Care System. This will transition to a self-paced exercise program for the remaining four months. After completion of the exercise program, Veterans will begin classroom-based cognitive training at the VA Palo Alto Health Care System (VAPAHCS). The cognitive training is based on an efficacious cognitive program that is structured around two components, pre-training and mnemonic training, both of which have been used successfully in persons with aMCI. Assessments of adherence will be administered throughout treatment and measures of feasibility will be completed post-treatment.

Participants will complete a variety of neuropsychological measures taping into areas of cognition such as attention, executive functioning, and memory. To study possible predictors of treatment response, the investigators will also collect biological (cardiovascular functioning and brain derived neurotrophic factor \[BDNF\] plasma levels) and genetic data (APOE and BDNF genotypes) from these participants. The investigators hope to provide initial evidence of the feasibility of a waterbased exercise training augmentation for cognitive training thus laying the groundwork for full-scale clinical trials targeting the lessening of cognitive impairment in persons with amnestic MCI by non-pharmacological means.
A nurse-led interview will be held about the health benefits of lifestyle change and regular physical activity, which are effective in all CV diseases.Initially starting with 10-15 minutes of physical activity, it will continue until it reaches a duration of 30 or 60 minutes, 3 times a week. The goal is to exceed the previous number of steps each time. A pedometer will be used to ensure regular follow-up and control, and the number of steps will be marked on the walking tracking chart. They will be told how to keep a record after each exercise. A weekly phone call will be made to motivate the patient and the researcher will be informed that they can call.Blood pressure measurement, BMI, Toronto AF Symptom Severity Scale, Short Form 36 (SF-36) scales and continuously recorded step counts will be evaluated at week 0, 4 and at the end of week 12.
Inventors have shown evidence of VEGF accumulation in extracellular Aβ plaques in the post-mortem brain of patients with Alzheimer's disease (AD) and of the APP/PS1 mouse model of AD. They identified specific binding domains involved in the direct interaction between A0o and VEGF and engineered a peptide that blocks this interaction. The designed peptide binds to Aβ oligomers with high affinity and inhibits the process of Aβ self-aggregation, leading to the blockade of fibrillar aggregation. Furthermore, the peptide prevents soluble Aβ-derived toxins to target synapses in hippocampal neuron cultures and restores long-term potentiation in the hippocampus of the APP/PS1 mouse model of Alzheimer's disease. Thus, these findings have broad implications for preventing and treating diseases with Aβ neurotoxicity such as Alzheimer's disease. Accordingly, the invention relates to a peptide comprising the amino acid sequence KRKKSRYKSWSVYVG (SEQ ID NO: 1).
Subjects will receive oral relacorilant 400 mg (4 X 100 mg softgel capsules) single dose on Day 1 after a high-fat meal. The study period in which a subject will receive this treatment will be determined by random assignment to 1 of 6 treatment sequences.
Patients receive osimertinib PO QD on days 1-28 of each cycle. Cycles repeat every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography or MUGA scan and blood sample collection throughout the study. Patients also undergo tumor biopsy on study and optionally at the end of treatment.
Technology is an indispensable part of our age and daily life . When we look at the research, it is seen that educational interventional preparation programs increase the harmony between both children, parents and health professionals. The increase in children's self-control and the elimination of unrealistic expectations may be related to the trust in healthcare professionals. Studies indicate that educational video animations are the most effective non-pharmacological method in reducing anxiety . Video animations will be useful for children because they create sound and images. It is believed that video animations with educational content that are understandable to children are essential for children's education. It is believed that animation shown to children will reduce their anxiety.
Discuss the availability of naloxone for the emergency treatment of opioid overdose with the patient and caregiver. Because patients being treated for opioid use disorder have the potential for relapse, putting them at risk for opioid overdose, strongly consider prescribing naloxone for the emergency treatment of opioid overdose, both when initiating and renewing treatment with SUBOXONE sublingual film. Also consider prescribing naloxone if the patient has household members (including children) or other close contacts at risk for accidental ingestion or opioid overdose [see Warnings and Precautions ( 5.2)] . 

Advise patients and caregivers that naloxone may also be administered for a known or suspected overdose with SUBOXONE sublingual film itself. Higher than normal doses and repeated administration of naloxone may be necessary due to the long duration of action of SUBOXONE sublingual film and its affinity for the mu-opioid receptor [see Overdosage ( 10)] . 

Inform patients and caregivers of their options for obtaining naloxone as permitted by individual state naloxone dispensing and prescribing requirements or guidelines (e.g., by prescription, directly from a pharmacist, or as part of a community-based program) [see Patient Counseling Information ( 17)] .
Patients were treated with video-assisted thoracoscopy under general anesthesia, according to a previously described protocol. In brief, PVI was performed from the epicardial side with a bipolar radiofrequency ablation clamp. At least 2 overlapping applications around each of the ipsilateral veins were made, and isolation was confirmed by the absence of PV potentials and exit block during pacing. In addition to PVI, the bilateral epicardial ganglia were found by high-frequency stimulation and ablated, as confirmed by the absence of a vagal response after ablation. Finally additional lines were made to create a posterior box lesion. Sensing and pacing maneuvers verified isolation of the posterior box.
The Self Awareness of Mental Health (SAM) is an adaptation of the Youth Awareness of Mental Health program, originally developed for the Saving and Empowering Young Lives in Europe (SEYLE) study. The SAM aims to raise mental health awareness about risk and protective factors associated with suicide, provide knowledge about depression and anxiety, and enhance the skills needed to cope with adverse life events and suicidal behavior. The intervention is delivered by trained clinical psychologists in five, 45-60 minutes, face-to-face sessions.
Healthy Chinese male subjects aged 18-45 years are recruited from a pool of over 200 healthy volunteers who had been genotyped for the SLCO1B1 388A\>G, 521T\>C and ABCG2 421C\>A polymorphisms. All subjects are required to abstain from any prescription or non-prescription medications 2 weeks before and throughout the study. They are not allowed to take alcohol, tea, grapefruit juice, caffeine, soybean milk or dietary supplements and herbal products 2 weeks before and throughout the entire study period. They are also not allowed to smoke 2 weeks before and throughout the study. Subjects are requested to fast for 10 h before and 4 h after drug administration during the blood sampling sessions. Meals are standardized and consumed at 4 h and 10 h post dosing. Drinking water are not allowed from 1 h pre-dose to 1 h post-dose except that needed for drug dosing at the time of blood sampling sessions. Subjects are given a single dose of simvastatin 20 mg (Zocor®, MSD) or rosuvastatin 10 mg (Crestor®, Astra Zeneca) on 3 occasions: 1. without herbs; 2. with green tea extract; 3. with soy isoflavones extract. The green tea extract and soy isoflavones extract are given at a dose containing EGCG 800 mg once daily or isoflavones 120 mg once daily for 14 days before statin dosing with at least 4-week washout period between phases.
BACKGROUND: The handstand is an essential skill in acrobatic sports. This skill requires the athlete to maintain an inverted upright stance with only the hands supported, which requires a great effort of muscular coordination and motor control. Several factors influence the ability to control the posture, including fatigue, which is a bit studied constraint of handstand performance.
RESEARCH QUESTION: With the aim to find out whether variability in movement control can be an indicator of fatigue, the present study was carried out.
METHOD: Fourteen male acrobatic gymnasts were required to perform handstands. The time series for analyzing variability were capturing using Force Platforms, which is a traditional laboratory instrument, and Inertial Measurement Units (IMU), which is a more recent and less widely used, but more accessible tool. For this purpose, an analysis of the amount of variability was carried out, using the standard deviation. And analysis of the structure of variability (or complexity), using Detrended Fluctuation Analysis (DFA) and Fuzzy Entropy (FuEn).
RESULTS: Our results reveal that fatigue causes significant increases in the amount of variability in the medio-lateral axis on the force platform, and in the IMU located in the area of the L5 vertebra. These changes are accompanied by increased auto-correlation in the medio-lateral axis of the force platform, and more unpredictable behavior in the L5 IMU.
This patent application presents a device and method for treating glioblastoma and other malignant tumors of the brain and central nervous system with ultraviolet radiation. The evidence for this possible treatment comes from a large statistical correlation between the incidence of these cancers and the strength of ultraviolet reaching the ground in that location. The weaker the ultraviolet, the more such tumors. The device uses the yearly intensity of ultraviolet from Hawaii, the place with the strongest ultraviolet and the lowest incidence rate for such malignant tumors. The method entails exposure to the ultraviolet in the device for twenty minutes a day, three times a week. The hope is that people with these malignant tumors will live longer than those not undergoing this treatment.
The device has a locking screw (4) with a threaded bore (5) and at least one carrier element. A releasable support hub (11) holds the implant (1) in a container. A ratchet insert (23) is releasably but non-rotatably connected to the implant. An adapter (6) is fastened to the implant by a central screw (8) screwed into the bore of the locking screw, and positively engages the carrier element.  The adapter is positively connected to the ratchet insert. A screwdriver (31) engaging the central screw is arranged in the ratchet insert.
Patients randomized to intervention arm during the 12 weeks after randomization will receive on their smartphone and/or via e-mail, information materials such as videos, images and recipes for reminders specifically designed to make patients aware on the importance of reducing dietary salt intake and suggestions on how to do it. The educational interventions will be delivered once a week. The main objective of the educational interventions is to spread knowledge about the health risks of excessive salt intake, the actual amount of salt in food, measures to reduce salt intake (e.g. use spices, eat fresh fruits and vegetables, check food labels, gradually reduce the salt in favorite recipes, avoid putting salt and salty sauces on the table, etc.). The interventions, conceived with nutritionists, will be delivered once a week to the participants and to their caregivers and/or the closest family member, involved in the food shopping and the preparation of meals.
Nitrofurantoin (macrocrystals) is a larger crystal form of nitrofurantoin. The absorption of nitrofurantoin (macrocrystals) is slower and its excretion somewhat less when compared to nitrofurantoin. Blood concentrations at therapeutic dosage are usually low. It is highly soluble in urine, to which it may impart a brown color.

Following a dose regimen of 100 mg q.i.d. for 7 days, average urinary drug recoveries (0 to 24 hours) on day 1 and day 7 were 37.9% and 35.0%.

Unlike many drugs, the presence of food or agents delaying gastric emptying can increase the bioavailability of nitrofurantoin capsules (macrocrystals), presumably by allowing better dissolution in gastric juices.
PURPOSE: A composition containing syringaresinol as an active ingredient is provided to suppress melanogenesis and tyrosinase activity, and to ensure anti-oxidation and skin whitening. CONSTITUTION: A composition for skin whitening contains 0.001-20wt% of syringaresinol as an active ingredient. The composition enhances the brightness and uniformity of skin color. The composition treats hyperpigmentation. The hyperpigmentation includes melasma, seborrheic keratosis, freckle, nevus, and dark circle. Syringaresinol is contained in an extract selected among a lindseed extract, a Phellodendri cortex extract, an Acanthopanacis cortex extract, a sesame extract, and a ginseng fruit extract. The composition is used for removing dead skin cells and promotes dead skin cell turn over. [Reference numerals] (AA) Syringaresinol
An exemplary medical diagnostic system includes one or more containers that may be used for medical diagnostic testing. Each container has an Identification (ID) tag associated with it. The ID tag of the container includes readable and writable memory. The memory is used to store information related to the container. The antenna is configured to wirelessly communicate with one or more ID tags associated with the container. The control system is configured to store the location of the container based on the identification of the antenna, select the antenna for communication with the ID tag, and read at least some information from or write at least some information to a memory on the ID tag using the antenna.
A medicated intrauterine device includes a preexisting contraceptive intrauterine platform (11) and an attachment (15) formed as a cylindrical sleeve (16) of base polymer containing a drug such as an antifertility agent. Local controlled release administration of the drug is added to the contraceptive effect of the preexisting platform. The attachment (15) can be made by centrifuging a medical grade of room temperature vulcanizing silicone rubber to remove reinforcing fillers therefrom. A selected quantity of the drug is mixed into the fillerless silicone rubber, and the drug and silicone mixture is injected into a multicavity mold. After the mixture sets and the sleeves (16) are removed from the mold, the sleeves are trimmed, then swollen by immersion in a solvent, and slipped onto the stem (12). An outer covering (17) over the sleeve (16) can control the drug release rate and impart greater strength to the fillerless silicone rubber of the attachment (15). The outer covering (17) can be a tube likewise swollen and slipped onto the sleeve (16) to tightly shrink thereon.
Intervention Group: Women randomized to the intervention group will be given a 3month membership to a community based exercise program, a pedometer and individual dietary recommendations. They will be asked to attend a minimum of three 45 minute to 60 minute exercise sessions per week but no more than five and will gradually build to walk 10,000 steps per day. Childcare and breastfeeding support will be provided. Trained research assistants will lead all group sessions. Weekly workout volume will be calculated and weekly steps will be monitored by research assistants. For the dietary intervention, the women will be provided 6oz of plain yogurt fortified with vitamin D post workout for the 12-week intervention. If any yogurt is out of date (expired), we will dispose of the expired yogurt. Weekly monitoring for the consumption of the yogurt and energy intake will be conducted by face-to-face or telephone interviews by research assistants.
The present invention relates to sanhuang capsules and a preparation technology thereof. The medicine and the preparation technology are provided for patients with osteoporosis. The Chinese medicine preparation is made from four traditional Chinese medicinal materials of soybean isoflavone, rhubarb, unprocessed rehmannia root, etc. The preparation technology for preparing the sanhuang capsules comprises four technologies that two kinds of medicine are made into powder, two kinds of medicine are decocted to thick paste, the powder and the thick paste are mixed to soft materials and pelletized, and granules are filled into the capsules. The sanhuang capsules have the advantages of less prescription medicine, simple preparation technology, low cost and convenience for oral administration. The present invention not only has significant curative effect on osteoporosis, but also has significant curative effect on climacteric syndrome and gonadal tumor diseases for women of middle and old age.
New DNA fragment (I) has a base sequence which relates to an antigen (Ag) associated with squamous cell carcinoma (SCC). (I) encodes for all or part of a 370 amino acid Ag which is reproduced in the specification. Also reproduced is a 1711 base sequence for (I). USE/ADVANTAGE - Ag (which can be isoalated from SCC of the cervix uteri, pulmonary or oesophagal carcinoma, etc.) is known as a diagnostic reagent for SCC but is not easily produced on a large scale from human cancer cells. By expressing (I) in E.coli, animal cells, etc., Ag can be prepd. in large quantities. Ag can also be as an immunogen (to produce antibodies, also useful diagnostically) while the Ag-encoding gene can be detected by hybridisation with (I). Ag is homologous with serine protease inhibitors so may be useful therapeutically.
PURPOSE:To obtain the title additive maintaining stretched and young and fresh state, suppressing melanin dyestuff formation, effective for beautifying skin, having excellent stability, containing L-ascorbic acid-2-phosphate and cyclodextrin as active ingredients. CONSTITUTION:A cosmetic additive containing L-ascorbic acid-2-phosphate or a salt thereof and cyclodextrin as active ingredients. Salts of the compounds of the active ingredients are Na, K, Mg or Ca, any type alpha, beta and gamma type of cyclodextrin is used as the cyclodextrin and beta type cyclodextrin is most preferable. 0.3-2 pts. wt. cyclodextrin is preferable based on 1 pt.wt. of the former compound. The amount of the additive added to cosmetics is 0.1-10wt.%, preferably 1-5wt.% calculated as cyclodextrin in the case of emulsion composition.