anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Aortoesophageal fistula (AEF) is an extremely rare and highly fatal complication leading to a high risk of morbidity and mortality. Successful management of AEF after esophagectomy for esophageal carcinoma has rarely been reported in the literature.
CASE PRESENTATION: Here we present a rare case of a 44-year-old female with complications of AEF after esophagectomy for esophageal carcinoma, mainly presented as vomiting of blood. Both computed tomographic and computed tomography angiography of the chest showed bilateral pleural effusion and atelectasis, while gastroscopy showed large gastrointestinal bleeding. Emergency surgery was performed that included the removal of the mediastinal abscess, left lower pulmonary wedge resection, and thoracic endovascular aortic repair (TEVAR), followed by supportive treatment. The surgery went successful, and the patient was followed up for 1 year after discharge and showed good recovery. We also reviewed previous literature on the history, causes, pathophysiology, clinical presentation, diagnosis, and treatment of AEF after esophagectomy for esophageal adenocarcinoma.
CONCLUSIONS: In our case, thoracotomy combined with TEVAR was effective in treating AEF after esophagectomy for esophageal adenocarcinoma. This case provides successful experiences for clinical diagnosis and treatment of AEF after esophagectomy for esophageal carcinoma.
PURPOSE:To provide a sebum-suppressing agent exhibiting mild effect and obtained by compounding TOSHISHI and/or its extract as an active component. CONSTITUTION:A remedy for dermatopathy exhibiting mild effect against seborrheic diseases such as acne caused by the excessive secretion of sebum is produced by using TOSHISHI (seed of Cuscuta japonica used singly or as a component of Chinese drug or crude drug preparation having tonic and restorative actions) powder or an extract of TOSHISHI powder produced by extracting with water or aqueous alcohol (e.g. ethanol) at 15-25 deg.C. The amount of the powder or extract is >=0.005wt% in the whole composition and up to 10% in total as dry residue. It can be used in any form applicable to the skin, e.g. cream, ointment, lotion, etc. The agent can be easily permeated into the skin and is absolutely free from irritation. The activity of the agent has no influence on organs other than sebum.
The present invention discloses plumepoppy injection for livestock which has the functions of broad-spectrum clearing away heat and toxic material, detumescence, antisepsis, antivirus and anti-inflammation. The present invention is refined by bocconia cordata and green chiretta through the production processes of alcohol step-by-step macerare for extracting active components, mixing compatibility, cold/heat processing, precipitation and trash extraction. The present invention is a pure nature green veterinary medicine product. The present invention has the effects of heat-clearing, detoxicating, detumescence, antisepsis, antivirus and antiinflammation. The present invention is used for curing various domestic animal influenza, upper respiratory tract infection, pneumonia, swine plague, infection of digestive canal, transmissible gastroenteritis, dysentery diarrhea, white and yellow diarrhea and of piglets, thermopolypneic diseases, viral infection, fowl cholera, white diarrhea of chicken, etc. The advantages of regulating pleiotropy and bidirectional traditional compatibility for treating diseases of the traditional Chinese medicine array effect are exerted by the present invention, and the refining advantage to the traditional Chinese medicine of the modern science and technology is embodied. The present invention has the advantages of convenient operation, broad application, obvious effect, conspicuous curative effect, stable quality, no toxic side effect, no residue, and in accordance with requirements of the current 'green production', etc.
Corynespora cassiicola is a highly diverse fungal pathogen that commonly occurs in tropical, subtropical, and greenhouse environments worldwide. In this study, the isolates were identified as C. cassiicola, and the optimum growth and sporulation were studied. The phenotypic characteristics of C. cassiicola, concerning 950 different growth conditions, were tested using Biolog PM plates 1-10. In addition, the strain of C. cassiicola DWZ from tobacco hosts was sequenced for the using Illumina PE150 and Pacbio technologies. The host resistance of tobacco Yunyan 87 with different maturity levels was investigated. In addition, the resistance evaluation of 10 common tobacco varieties was investigated. The results showed that C. cassiicola metabolized 89.47% of the tested carbon source, 100% of the nitrogen source, 100% of the phosphorus source, and 97.14% of the sulfur source. It can adapt to a variety of different osmotic pressure and pH environments, and has good decarboxylase and deaminase activities. The optimum conditions for pathogen growth and sporulation were 25-30 °C, and the growth was better on AEA and OA medium. The total length of the genome was 45.9 Mbp, the GC content was 51.23%, and a total of 13,061 protein-coding genes, 202 non-coding RNAs and 2801 and repeat sequences were predicted. Mature leaves were more susceptible than proper mature and immature leaves, and the average diameter of diseased spots reached 17.74 mm at 12 days. None of the tested ten cultivars exhibited obvious resistance to Corynespora leaf spot of tobacco, whereby all disease spot diameters reached > 10 mm and > 30 mm when at 5 and 10 days after inoculation, respectively. The phenotypic characteristics, genomic analysis of C. cassiicola and the cultivar resistance assessment of this pathogen have increased our understanding of Corynespora leaf spot of tobacco.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology, and can be used for management of labour in pregnant women with transplanted kidney. For this purpose labour is realised by Cesarean section by transversal suprapubic access on uterus in lower segment. When extracting head of fetus methyl prednisolone in dose 500-750 mg is introduced intravenously (bolus pulse-therapy). Immediately after operation introduced is azathioprin in dose 100 mg/day. In postnatal period antibacterial therapy with cephalosporins of III and IV generations is carried out for 7-10 days. Sutures are removed on 7-10 day. Breastfeeding is contraindicated. ^ EFFECT: method of labour management in pregnant women with transplanted kidney makes it possible for said group of women to have children and at the same time avoid transplant rejection, also observed has been birth of alive children, developing according to their age, who did not develop urinary system diseases. ^ 2 ex
According to one or more aspects of the present disclosure a wearable oral device is provided. The wearable oral device may include a mouthpiece; a bone conduction component; and a processing device. The processing device may detect one or more user interactions by a first user with the wearable oral device; and perform one or more operations in view of the one or more user interactions. The one or more user interactions may include a user interaction by the first user with the mouthpiece. The one or more operations may include presenting a content item via the bone conduction component of the wearable oral device. The content item may include audio content. In some embodiments, the content item comprises a voice message from a second user.
BACKGROUND: Pleural disease is common, representing 5% of the acute medical workload, and its incidence is rising, partly due to the ageing population. Frailty is an important feature and little is known about disease progression in patients with frailty and pleural disease. We aimed to examine the effect of frailty on mortality and other relevant outcomes in patients diagnosed with pleural disease.
METHODS: In this cohort study in Wales, the national Secure Anonymised Information Linkage databank was used to identify a cohort of individuals diagnosed with non-malignant pleural disease between Jan 1, 2005, and March 1, 2023, who were not known to have left Wales. Frailty was assessed at diagnosis of pleural disease using an electronic Frailty Index. The primary outcome was time from diagnosis to all-cause mortality for all patients. Data were analysed using multilevel mixed-effects Cox proportional hazards regression adjusting for the prespecified covariates of age, sex, Welsh Index of Multiple Deprivation quintile, smoking status, comorbidity, and subtype of pleural disease.
FINDINGS: 54 566 individuals were included in the final sample (median age 66 years [IQR 47-77]; 26 477 [48·5%] were female and 28 089 [51·5%] were male). By the end of the study period, 25 698 (47·1%) participants had died, with a median follow-up of 1·0 years (IQR 0·2-3·6). There was an association between frailty and all-cause mortality, which increased as frailty worsened. Compared with fit individuals, there was increasing mortality for those with mild frailty (adjusted hazard ratio 1·11 [95% CI 1·08-1·15]; p<0·0001), moderate frailty (1·25 [1·20-1·31]; p<0·0001), and severe frailty (1·36 [1·28-1·44]; p<0·0001).
INTERPRETATION: Independent of age and comorbidities, frailty status at diagnosis of pleural disease appeared to be useful as a prognostic indicator. Patients with moderate or severe frailty had a rapid decline in health. Future patients should be assessed for frailty at the time of diagnosis of pleural disease and might benefit from optimised care and advance care planning.
FUNDING: Cardiff University's Wellcome Trust iTPA funding award.
"Objective: To evaluate the risk factors of pregnancy-related thrombotic microangiopathies and the effect of plasma exchange on the prognosis (recovery status of renal function, recovery status of platelets, survival or death within 28 days).

Design: A retrospective analysis of pregnant patients admitted to the ICU from 2015 to 2019. According to the outcome indicator of the occurrence of pregnancy-related thrombotic microangiopathies, they were divided into thrombotic microangiopathies group and non-thrombotic microangiopathies group. Patients in the pregnancy-related thrombotic microangiopathy group were divided into plasma exchange combined non-plasma exchange group according to whether they received plasma exchange. Collect the clinical data of the patients, and analyze the data using SPSS 1 7.0 statistical software package. The measurement data were compared by paired t test and one-way analysis of variance; the count data were compared by χ2 test. Compare the differences of the indicators between the two groups and analyze the risk factors of pregnancy-related thrombotic microangiopathies. Then compare whether there is a difference in the prognosis between the plasma exchange group and the non-plasma exchange group."
Participants attend 2 teaching sessions with a research nurse. Participants also complete questionnaires at baseline, 3, and 7 weeks.
Patients will receive induction chemotherapy with gemcitabine (1g/m2, d1 \& 8 of every cycle) and cisplatin (80mg/m2, d1 of every cycle), every 3 weeks for 3 cycles before radiation. Definitive intensity-modulated radiotherapy (IMRT) of 6996cGy in 33 fractions will be given. Concurrent cisplatin of 100mg/m2 will be administered every 3 weeks for 2 cycles during IMRT. Sintilimab 200mg will be given every 3 weeks for 12 cycles, started on day 1 of induction chemotherapy.
The invention mainly discloses a lymph node registration method and device, computer equipment and a storage medium. The method comprises the steps of obtaining a plurality of key points in a first image and a second image, wherein the first image and the second image are images of the same object in different time. The location of the lymph node in the first image and the second image is acquired. And mapping the positions of the key points and the lymph nodes in the first image and the second image to a calibration coordinate system. A pair of lymph nodes in the first image and in the second image having a distance between each lymph node in the first image less than a predetermined threshold in the calibration coordinate system is determined to be an initially registered pair of lymph nodes. Vectors formed between each lymph node in the initially registered pair of lymph nodes and the keypoint are acquired under a calibrated coordinate system. The registered lymph node pairs are determined based on vectors and bipartite mapping formed between each lymph node in the initially registered pair and the keypoints. The scheme improves the registration speed and the registration accuracy.
This group will receive only the saphenous nerve block mixture including 20 ml of 0.25% bupivacaine with 1:400,000 epinephrine. Dexamethasone will not be administered to this group systemically or perineural.
Nursing is a profession that emerged as a result of social needs and has very old roots. In order to evaluate the current situation of a profession, it is very important to know its history, the reasons for its emergence, the processes it has gone through from past to present, and its development processes. The contributions of the nursing profession to society and understanding its science and art dimensions can only be explained through the history of nursing. Therefore, the importance of professional history courses in nursing education cannot be denied. Teaching the history of nursing in detail strengthens the identity of nursing and develops students' critical thinking and problem-solving skills. It also allows nurses to demonstrate their self-efficacy. In addition, it helps develop a strong professional identity. In addition, improving nurses' historical knowledge directly affects their perception of the profession, attitude towards the profession, and nursing care. Correct historical awareness will enable nurses to learn from past practices and distinguish practices that are not suitable for nursing today. Therefore, it is very important to teach nursing history in undergraduate nursing education.The population of the research will consist of 200 second-year students enrolled in the Nursing History and Deontology course at the Faculty of Nursing of a state university in Turkey.Among the students who meet the criteria to participate in the research, 132 students will be determined by simple random sampling method by creating a simple random numbers table. The selected 132 students will be randomly assigned to two groups of 66 students (control and intervention) so that the overall academic achievement score of both groups is homogeneous.Data; It will be collected with the Introductory Features Form, Nursing History Knowledge Test and Nursing History Teaching Evaluation Form.
An intravaginal treatment device (ITD) provides therapeutic light and fluid treatments. Vision systems throughout supporting networks and devices allow for directed control of the treatment processes. The ITD uses illumination to gather various types of imager data that is used to identify and conditions, monitor the treatment process, and evaluate treatment efficacy. Specific frequency light emissions and associated fluids are used to reduce overabundant flora, at least assist in elimination of fungal, viral and bacterial invaders, and enhance the detection process. Several configurations and sizes of ITDs with light and fluid therapy, also have a built in optics assembly (camera, light sources, etc.) for capturing intravaginal still images and video of vaginal channels, cervix, cervical channels, uterus and fallopian tubes. Some ITD configurations are also wearable and include full fluid delivery infrastructure unlike some other ITDs with external components. Supporting devices include local and remotely located computing devices such as laptops, smart phones, and independent monitors. ITDs can be fully or partially inserted via the vaginal channel, and operate in a stand-alone mode or pursuant to remote control. Therapy procedures may be preset or programmed to deliver continuous, periodic and scheduled performance with various underlying parameters defined in the preset or programming processes.
In an aspect, embodiments of the invention relate to the effective and accurate placement of intravascular devices such as central venous catheters, in particular such as peripherally inserted central catheters or PICC. One aspect of the present invention relates to vascular access. It describes devices and methods for imaging guided vascular access and more effective sterile packaging and handling of such devices. A second aspect of the present invention relates to the guidance, positioning and placement confirmation of intravascular devices without the help of X-ray imaging. A third aspect of the present invention relates to devices and methods for the skin securement of intravascular devices and post-placement verification of location of such devices. A forth aspect of the present invention relates to improvement of the workflow required for the placement of intravascular devices.
A topically applied composition capable of treating subcutaneous tissue comprising an alkali metal hypohalite (AMH) (preferably, sodium hypochlorite) and a conventional skin lotion. The skin lotion serves both as a carrier and as an antidrying agent for the AMH. The AMH penetrates through the skin's pores and lymph nodes into the subcutaneous tissue. The AMH stimulates the immune system to alleviate, and sometimes cure, inflammation, aches, pains, and other symptoms caused by microbial (e.g., viral, bacterial, fungal and parasitic) infection, arthritis, hemorrhoids, allergies, etc . . .
In the PPV group, fluids will be administered to maintain the PPV below 13%. If hypotension coincided with a PPV exceeding 13%, an initial bolus of 200 ml crystalloid fluid solution will be given in10 minutes. PPV reassessment occurred within the subsequent 10 minutes. Alternatively, if hypotension occurs with a PPV measuring less than 13%, vasopressors such as ephedrine at a dose of 3-6 mg or norepinephrine at a dosage of 5-10 mcg intravenously as a bolus, or norepinephrine infusion at a rate of 0.03-0.3 mcg/kg/min, will be given to sustain mean arterial pressure above 65 mmHg.
EXOB-001 will be administered via the endotracheal route in an already intubated newborn. EXOB-001 will be administered in three dose levels (low dose, medium dose and high dose) with one or three administrations.
PURPOSE:To provide the subject medicinal agent containing interleukin-1alpha or its derivative as an active ingredient and capable of stimulating the multiplication and differentiation of undifferentiated hematinic cell precursors to remarkably promote the restoration of erythroid cells. CONSTITUTION:The objective medicinal agent contains a compound selected from interleukin-1alpha (IL-1alpha) and its derivatives as an active ingredient. The IL-1alpha is obtained e.g. by forming such a recombinant DNA that a gene coding the IL-1alpha can be expressed in a host cell, introducing the recombinant DNA into a vector, transforming the host cell with the vector and subsequently culturing the transformant to express the IL-1alpha. A mild method such as an osmotic pressure shock method is preferable as a method for extracting the IL-1alpha from the host cell from a viewpoint for holding its high order structure. The medicinal agent is preferably administered so that the dose of the active ingredient is 0.01mug to 10 mg per adult a day.
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures in males. Here, we investigated the IHKA model in female mice, in particular drug-resistance of HPDs and the influence of antiseizure medications (ASMs) on the power spectrum. After injecting kainic acid (KA) unilaterally into the hippocampus of female mice, we monitored the development of epileptiform activity by local field potential (LFP) recordings. Subsequently, we evaluated the effect of the commonly prescribed ASMs lamotrigine (LTG), oxcarbazepine (OXC) and levetiracetam (LEV), as well as the benzodiazepine diazepam (DZP) with a focus on HPDs and power spectral analysis and assessed neuropathological alterations of the hippocampus. In the IHKA model, female mice replicated key features of human TLE as previously described in males. Importantly, HPDs in female mice did not respond to commonly prescribed ASMs in line with the drug-resistance in males, thus representing a suitable model of drug-resistant seizures. Intriguingly, we observed an increased occurrence of generalized seizures after LTG. Power spectral analysis revealed a pronounced increase in the delta frequency range after the higher dose of 30 mg/kg LTG. DZP abolished HPDs and caused a marked reduction over a wide frequency range (delta, theta, and alpha) of the power spectrum. By characterizing the IHKA model of TLE in female mice we address an important gap in basic research. Considering the special challenges complicating the therapeutic management of epilepsy in women, inclusion of females in preclinical studies is imperative. A well-characterized female model is a prerequisite for the development of novel therapeutic strategies tailored to sex-specific needs and for studies on the effect of epilepsy and ASMs during pregnancy.
OBJECTIVES: Older adults may be under-represented in critical care research, and results may not apply to this specific population. Our primary objective was to evaluate the prevalence of inclusion of older adults across critical care trials focused on common ICU conditions or interventions. Our secondary objective was to evaluate whether older age was used as a stratification variable for randomization or outcome analysis.
DESIGN SETTING AND SUBJECTS: We performed a systematic review of previously published systematic reviews of randomized controlled trials (RCTs) in critical care. We searched PubMed, Ovid, CENTRAL, and Cochrane from 2009 to 2022. Systematic reviews of any interventions across five topics: acute respiratory distress syndrome (ARDS), sepsis/shock, nutrition, sedation, and mobilization were eligible.
MAIN RESULTS: We identified 216 systematic reviews and included a total of 253 RCTs and 113,090 patients. We extracted baseline characteristics and the reported proportion of older adults. We assessed whether any upper age limit was an exclusion criterion for trials, whether age was used for stratification during randomization or data analysis, and if age-specific subgroup analysis was present. The most prevalent topic was sepsis (78 trials, 31%), followed by nutrition (62 trials, 25%), ARDS (39 trials, 15%), mobilization (38 trials, 15%), and sedation (36 trials, 14%). Eighteen trials (7%) had exclusion criteria based on older age. Age distribution with information on older adults prevalence was given in six trials (2%). Age was considered in the analysis of ten trials (5%) using analytic methods to evaluate the outcome stratified by age.
CONCLUSIONS: In this systematic review, the proportion of older critically ill patients is undetermined, and it is unclear how age is or is not an effect modifier or to what extent the results are valid for older adult groups. Reporting age is important to guide clinicians in personalizing care. These results highlight the importance of incorporating older critically ill patients in future trials to ensure the results are generalizable to this growing population.