anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Previous studies indicate that eosinophils are recruited into the allograft following orthotopic liver transplantation and protect from ischaemia reperfusion (IR) injury. In the current studies, we aim to explore whether their protective function could outlast during liver repair.
DESIGN: Eosinophil-deficient mice and adoptive transfer of bone marrow-derived eosinophils (bmEos) were employed to investigate the effects of eosinophils on tissue repair and regeneration after hepatic IR injury. Aside from exogenous cytokine or neutralising antibody treatments, mechanistic studies made use of a panel of mouse models of eosinophil-specific IL-4/IL-13-deletion, cell-specific IL-4rα-deletion in liver macrophages and hepatocytes and macrophage-specific deletion of heparin-binding epidermal growth factor-like growth factor (hb-egf).
RESULT: We observed that eosinophils persisted over a week following hepatic IR injury. Their peak accumulation coincided with that of hepatocyte proliferation. Functional studies showed that eosinophil deficiency was associated with a dramatic delay in liver repair, which was normalised by the adoptive transfer of bmEos. Mechanistic studies demonstrated that eosinophil-derived IL-4, but not IL-13, was critically involved in the reparative function of these cells. The data further revealed a selective role of macrophage-dependent IL-4 signalling in liver regeneration. Eosinophil-derived IL-4 stimulated macrophages to produce HB-EGF. Moreover, macrophage-specific hb-egf deletion impaired hepatocyte regeneration after IR injury.
CONCLUSION: Together, these studies uncovered an indispensable role of eosinophils in liver repair after acute injury and identified a novel crosstalk between eosinophils and macrophages through the IL-4/HB-EGF axis.
This invention relates to a health-care beverage with Panji as main ingredient and its prepn. method. Its components (pts. wt.) are grain distillate spirit 500-650, Panji 35-250, wolfberry fruit 30-100 and epimedium 50-150. The process for preparing the wine mainly includes selecting raw materials, pre-treatment, soaking and filtering. This wine has easily available materials, simple processing and good mouth feeling, benefits protection of liver, reinforces non-specific immunity of organism, and has obious curative effect on enhancing hematopoiesis, impotence and prospermia.
FIELD: medicine. SUBSTANCE: invention relates to materials used in reconstructive osseous-recovery plastic surgery, traumatology and orthopedics. Material consists of treated, defatted and lyophilized porous osseous tissue with pore size from 0.05 to 5 mm on surface of that the composition prepared of biocompatible copolymer and physiologically active substances is applied in the following ratio of components in composition, wt.-%: biocompatible copolymer of vinylpyrrolidone with acrylates, 50-99; physiologically active substances, 1-50, in the ratio of porous osseous tissue to physiologically active polymeric composition, wt.-%: osseous tissue, 60- 99.3; physiologically active polymeric composition, 0.7-40. Material exhibits the enhanced mechanical strength and provides the prolonged topical antibacterial effect and effect stimulating the bone regeneration. EFFECT: valuable properties of material. 5 ex
The present invention relates to a tissue for skin care capable of allowing a gravure coating device (14) to coat a first coating composition (A) on one surface of a nonwoven fabric strip (4) which is continuously supplied, being folded by half while passing through a folding guide (6), being continuously folded by a folding roll (8), being cut by a cutter (10), being formed in bundle folding (12) in which a plurality of sheet tissues (2) are folded, and injecting and sealing a second impregnation composition by being packed with a pouch film (P). The sheet tissue (2) is one among an aqueous or oily cleaning tissue, a sun tissue, or a deodorant tissue. The first coating composition (A) is a common component in which a moisturizing agent, a preservative, a flavoring agent, an active ingredient, a chelate agent, a pH adjuster, a viscosity increasing agent, and a surfactant are mixed in purified water. A scrub agent is only added to the aqueous cleansing tissue and the deodorant tissue. An emulsifier is only added to the oily cleaning tissue and the sun tissue. An emollient is only added to the oily cleaning tissue, and an inorganic sun blocking agent is only added to the sun tissue. The second impregnation composition (B) is a common component in which the moisturizing agent, the preservative, the chelate agent, and the pH adjuster are mixed with the purified water. The surfactant is only added to the oily cleaning tissue and the sun tissue. The emulsifier is only added to the oily cleaning tissue. The sun tissue is obtained by further adding the viscosity increasing agent, an organic sun blocking agent, an emulsifying stabilizer, and the emollient to the sun tissue only.
BACKGROUND: Inflammatory bowel disease may affect the pathogenesis and clinicopathologic course of colorectal cancer. We sought to characterize the impact of inflammatory bowel disease on outcomes after colectomy and/or proctectomy for a malignant indication.
METHODS: Patients diagnosed with colorectal cancer as well as a pre-existing comorbid diagnosis of Crohn's disease or ulcerative colitis between 2018 and 2021 were identified from Medicare claims data. The postoperative textbook outcome was defined as the absence of complications, as well as no extended hospital stay, 90-day readmission, or mortality. Postdischarge disposition and expenditures were also examined.
RESULTS: Among 191,684 patients with colorectal cancer, 4,770 (2.5%) had a pre-existing diagnosis of inflammatory bowel disease. Patients with inflammatory bowel disease-associated colorectal cancer were less likely to undergo surgical resection (no inflammatory bowel disease: 47.6% vs inflammatory bowel disease: 42.1%; P < .001). Among patients who did undergo colorectal surgery, individuals with inflammatory bowel disease were less likely to achieve a textbook outcome (odds ratio 0.64 [95% confidence interval 0.58-0.70]). In particular, patients with inflammatory bowel disease had higher odds of postoperative complications (odds ratio 1.24 [1.12-1.38]), extended hospital stay (odds ratio 1.41 [1.27-1.58]), and readmission within 90 days (odds ratio 1.56 [1.42-1.72]) (all P < .05). Patients with inflammatory bowel disease-associated colorectal cancer were less likely to be discharged to their home under independent care (odds ratio 0.77 [0.68-0.87]) and had 12.2% higher expenditures, which correlated with whether the patient had a postoperative textbook outcome.
CONCLUSION: One in 40 patients with colorectal cancer had concomitant inflammatory bowel disease. Inflammatory bowel disease was associated with a lower probability of achieving ideal postoperative outcomes, higher postdischarge expenditure, as well as worse long-term survival after colorectal cancer resection.
BACKGROUND: Bilateral cages are often used for interbody fusion. However, this procedure may not be possible in some cases making unilateral cages a reasonable alternative. The literature remains divided on the clinical and radiological distinctions when comparing unilateral to bilateral cages in lumbar interbody fusion. Thus, this meta-analysis will analyze the clinical and radiographic outcomes between these 2 groups.
METHODS: PubMed, Cochrane, and Google Scholar (page 1-20) were searched till January 2024. The clinical outcomes evaluated were the incidence of adverse events, surgery-related parameters, and patient reported outcomes.
RESULTS: Lower rates of pseudoarthrosis, subsidence, were reported in the bilateral cages group (P = 0.01, P = 0.001, respectively) whereas shorter operative time (OR time), and lower estimated blood loss were seen in unilateral cage group (P < 0.001, and P = 0.003). There was no statistically significant difference in the remaining analyzed outcomes.
CONCLUSIONS: Unilateral cages were shown to be superior due to their reduced OR time and estimated blood loss. As for the higher rate of pseudoarthrosis, this outcome may not be related to the cage numbers and it did not affect clinical outcomes. Nevertheless, one must consider other factors such as radiographic sagittal parameters before making a surgical decision.
BACKGROUND: Few studies have observed the direct effect of obesity on renal prognoses in immunoglobulin A nephropathy (IgAN) or separately evaluated its effects according to sex. We aimed to evaluate the direct and indirect effects of obesity on the renal outcomes of IgAN and observe these effects separately according to renal function and sex.
METHODS: We extracted patients with body mass index (BMI) descriptions from a multicenter retrospective cohort analysis in Japan, and excluded those with < 30 days of follow-up, diabetes mellitus, and steroid treatment. Patients were divided into normal (n = 720; 18.5 ≤ BMI < 25) and obese (n = 212; BMI ≥ 25) groups, which were then compared. The endpoints were a 1.5-fold increase in serum creatinine levels and the initiation of renal replacement therapy.
RESULTS: The obese group was older, included more males, and was more likely have hypertension, dyslipidemia, proteinuria, tubular atrophy, and lower renal function than the normal group. Patients with an eGFR < 60 mL/min/1.73 m2 had well-matched characteristics between the groups; however, hypertension, low high-density lipoprotein cholesterol, and hypertriglyceridemia were more common in the obese group. Obesity contributed to tubular atrophy, even when adjusted for renal function. In addition, it contributed to proteinuria only in females. However, obesity itself was not a significant prognostic factor.
CONCLUSIONS: Although no independent effect on renal prognosis was observed during the study period, the obese group had more risk factors for IgAN progression and obesity contributed to tubular atrophy and female proteinuria. Our results suggest that separately analyzing the prognostic effect of obesity according to sex is important.
The usual adolescent and geriatric dose is 25 mg to 100 mg daily.

Dosage should be initiated at a lower level and increased according to tolerance and clinical response to a usual maximum of 100 mg daily. In more severely ill patients, dosage may be further increased to 150 mg/day. Doses above 150 mg/day are not recommended in these age groups.

Initial therapy may be administered in divided doses or a single daily dose.

Maintenance therapy may be given on a once-daily schedule for patient convenience and compliance.

Switching a Patient to or From a Monoamine Oxidase Inhibitor (MAOI) Intended to Treat Psychiatric Disorders:  At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with NORPRAMIN. Conversely, at least 14 days should be allowed after stopping NORPRAMIN before starting an MAOI intended to treat psychiatric disorders (see CONTRAINDICATIONS).

Use of NORPRAMIN With Other MAOI’s Such as Linezolid or Methylene Blue:

Do not start NORPRAMIN in a patient who is being treated with linezolid or intravenous methylene blue because there is increased risk of serotonin syndrome. In a patient who requires more urgent treatment of a psychiatric condition, other interventions, including hospitalization, should be considered (see CONTRAINDICATIONS).

In some cases, a patient already receiving NORPRAMIN therapy may require urgent treatment with linezolid or intravenous methylene blue. If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, NORPRAMIN should be stopped promptly, and linezolid or intravenous methylene blue can be administered. The patient should be monitored for symptoms of serotonin syndrome for 2 weeks or until 24 hours after the last dose of linezolid or intravenous methylene blue, whichever comes first. Therapy with NORPRAMIN may be resumed 24 hours after the last dose of linezolid or intravenous methylene blue (see WARNINGS).

The risk of administering methylene blue by non-intravenous routes (such as oral tablets or by local injection) or in intravenous doses much lower than 1 mg/kg with NORPRAMIN is unclear. The clinician should, nevertheless, be aware of the possibility of emergent symptoms of serotonin syndrome with such use (see WARNINGS).
After installing the disposable treatment head coat, the transplanted kidney was treated with an ultrasonic therapeutic apparatus; after the treatment, the disposable treatment head coat was removed. Patients were treated twice a week for 6 weeks.
INTRODUCTION: To evaluate the diagnostic efficiency among the clinical model, the radiomics model and the nomogram that combined radiomics features, frozen section (FS) analysis and clinical characteristics for the prediction of lymph node (LN) metastasis in patients with papillary thyroid cancer (PTC).
METHODS: A total of 208 patients were randomly divided into two groups randomly with a proportion of 7:3 for the training groups (n = 146) and the validation groups (n = 62). The Least Absolute Shrinkage and Selection Operator (LASSO) regression was used for the selection of radiomics features extracted from ultrasound (US) images. Univariate and multivariate logistic analyses were used to select predictors associated with the status of LN. The clinical model, radiomics model and nomogram were subsequently established by logistic regression machine learning. The area under the curve (AUC), sensitivity and specificity were used to evaluate the diagnostic performance of the different models. The Delong test was used to compare the AUC of the three models.
RESULTS: Multivariate analysis indicated that age, size group, Adler grade, ACR score and the psammoma body group were independent predictors of lymph node metastasis (LNM). The results showed that in both the training and validation groups, the nomogram showed better performance than the clinical model, albeit not statistically significant (p > .05), and significantly outperformed the radiomics model (p < .05). However, the nomogram exhibits a slight improvement in sensitivity that could reduce the incidence of false negatives.
CONCLUSION: We propose that the nomogram holds substantial promise as an effective tool for predicting LNM in patients with PTC.
INTRODUCTION: Benign prostatic hyperplasia (BPH) is a common urological condition, particularly among middle-aged and elderly men. Trans urethral resection of prostate (TURP) has some drawbacks, particularly concerning ejaculatory function. Ejaculation preserving TURP (Ep-TURP) is one such technique that aims at preserving the tissues that are primarily responsible for antegrade ejaculation.
METHODS AND MATERIAL: In this prospective study, patients with bothersome LUTS were randomized into Ep-TURP and standard TURP groups. Supramontal tissue was preserved in Ep-TURP while standard TURP group had resection of the entire prostatic tissue up to the verumontanum. The outcomes with regard to IPSS, Qmax, IIEF(Q9), Ejaculation and PVR were studied. Ejaculation projection score was separately calculated and assessed.
RESULTS: About 60 patients were studied, with 30 in each group. At 6 months' follow-up, complication rates were the same in both groups. The IPSS, Qmax, IIEF were similar and comparable. There was no change in erection in all patients (P = 0.559). The ejaculation was well preserved in Ep-TURP (p<0.001). Ejaculation projection score was maintained at 3.77 in the Ep-TURP group while in the standard group it was 0 (P<0.001).
CONCLUSIONS: Ep-TURP is a safe and a cost-effective method of preserving ejaculation in patients undergoing TURP. This procedure adds a better quality of life that greatly aids in enhancing the improving his psychological outlook towards life. Ep-TURP has now emerged as the standard procedure of choice in sexually active young males needing TURP, as the degree of ejaculation is largely well preserved in patients undergoing this procedure.
The invention discloses a traditional Chinese medicine composition for treating an ischemic heart and cerebral vessel disease. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of fresh dendrobium officinale strips, 1-2 parts of codonopsis pilosula, 1-2 parts of achyranthes bidentata, 1-2 parts of leonurus japonicus houtt. and 1-2 parts of panax notoginseng. The preparation method of the traditional Chinese medicine composition for treating the ischemic heart and cerebral vessel disease comprises the six steps of weighing the raw materials, treating the fresh dendrobium candidum strips, treating panax notoginseng, performing water extraction, drying and blending the materials. The traditional Chinese medicine composition has the advantages that dendrobium candidum and codonopsis pilosula serve as main drugs; dendrobium candidum has the effects of nourishing yin, increasing fluids, accumulating essence, benefiting vigor and tonifying five viscera; codonopsis pilosula has the effects of strengthening a middle warmer, tonifying qi, promoting salivation and nourishing blood; radix achyranthis bidentatae, leonurus japonicus houtt. and panax notoginseng serve as auxiliary drugs, and have effects of promoting circulation and removing a stasis; in addition, radix achyranthis bidentatae has the effects of nourishing a liver and a kidney; leonurus japonicus houtt. has the effect of inducing diuresis to reduce edema; panax notoginseng has the effect of alleviating pain; and symptoms are alleviated from multiple aspects. The traditional Chinese medicine composition can treat both symptoms and root causes; the raw materials are combined for use, so that the effects of nourishing yin, tonifying qi, promoting blood circulation and dredging collaterals are exerted; and the traditional Chinese medicine composition has good treatment effect on the ischemic heart and cerebral vessel disease.
Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies1,2. Age-related changes in populations of self-renewing haematopoietic stem cells (HSCs) are thought to underlie these phenomena3. During youth, HSCs with balanced output of lymphoid and myeloid cells (bal-HSCs) predominate over HSCs with myeloid-biased output (my-HSCs), thereby promoting the lymphopoiesis required for initiating adaptive immune responses, while limiting the production of myeloid cells, which can be pro-inflammatory4. Ageing is associated with increased proportions of my-HSCs, resulting in decreased lymphopoiesis and increased myelopoiesis3,5,6. Transfer of bal-HSCs results in abundant lymphoid and myeloid cells, a stable phenotype that is retained after secondary transfer; my-HSCs also retain their patterns of production after secondary transfer5. The origin and potential interconversion of these two subsets is still unclear. If they are separate subsets postnatally, it might be possible to reverse the ageing phenotype by eliminating my-HSCs in aged mice. Here we demonstrate that antibody-mediated depletion of my-HSCs in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Depletion of my-HSCs in aged mice improves primary and secondary adaptive immune responses to viral infection. These findings may have relevance to the understanding and intervention of diseases exacerbated or caused by dominance of the haematopoietic system by my-HSCs.
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Cemented hip arthroplasty is strongly associated with bone cement implantation syndrome (BCIS). It is characterized by hypoxia, hypotension and/or unexpected loss of consciousness occurring around the time of cementation, prosthesis insertion or reduction of the joint. It has been shown to increase cardiovascular and renal complication and brain damage postoperatively. Remote-ischemic preconditioning has shown kidney, myocardial and brain injury protective effect on non-cardiac surgery patients. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.
PURPOSE: A composition containing Chrysanthemum zawadskii var. latilobum Kitamura extract is provided to reduce joint inflammation and to suppress inflammatory mediator(MMP-1,MMP-3,RANTES) and cytokines(TNF-alpha,IL-1beta). CONSTITUTION: A pharmaceutical composition for preventing and treating arthritis contains Chrysanthemum zawadskii var. latilobum Kitamura extract. The extract is prepared from Chrysanthemum zawadskii var. latilobum Kitamura, Chrysanthemum zawadskii var. tenuisectum, Chrysanthemum zawadskii subsp. Coreanum, Chrysanthemum zawadskii subsp. Naktongense, or Chrysanthemum zawadskii var. alpinum by hot water extraction or solvent extraction. The hot water extraction comprises: a step of washing Chrysanthemum zawadskii var. latilobum Kitamura with distilled water and pulverizing; a step of heating Chrysanthemum zawadskii var. latilobum Kitamura in hot water at 100-120 Deg. C. for 2-3 hours to prepare Chrysanthemum zawadskii var. latilobum Kitamura extract; a step of filtering the Chrysanthemum zawadskii var. latilobum Kitamura extract and collecting supernatant; a step of concentrating the supernatant; and a step of freeze-drying the concentrate at -80 Deg. C.
PROBLEM TO BE SOLVED: To provide an elastic mold for molding capable of molding a molding having good dimensional accuracy. SOLUTION: The elastic mold 1 for molding used for a method for molding a molding by expanding a mold according to an atmospheric pressure difference and removing the molding is a hollow elastic mold molded by using in combination two or above molds. The mold 1 is formed of a silicone resin. The mold 1 has a thickness of a film of 1 to 5 m, and a hardness of the film of 10 to 60 [a value measured according to a spring type hardness test (A-type) of JIS K 6301]. As the resin, a cured addition type liquid-like silicone is preferably used. As the cured silicone rubber, a cured silicone rubber obtained by crosslinking an α-ω divinylpolydimethylpolysiloxane with a polysiloxane having an Si-H bond is preferable.
BACKGROUND: To assess the influence of diagnosis and referral provided by specialists in oral diagnosis on disease-free survival and overall survival of patients with oral cancer.
METHODS: A cohort of 282 patients with oral cancer treated at a regional cancer hospital from 1998 to 2016 was analyzed retrospectively. The referral register of the patients was analyzed and assigned to two groups: (1) those referred by oral diagnosis specialists (n = 129), or (2) those referred by nonspecialized professionals (n = 153). The cancer treatment evolution was assessed from the patients' records, and the outcome was registered concerning cancer recurrence and death. Sociodemographic and clinicopathological variables were explored as predictors of disease-free survival and overall survival.
RESULTS: Group 1 exhibited lower T stages and a reduced incidence of regional and distant metastases. Surgery was performed in 75.2% of cases in Group 1, while in Group 2, the rate was 60.8%. Advanced T stages and regional metastases reduced the feasibility of surgery. Higher TNM stages and tumor recurrence were associated with decreased disease-free survival, while surgical intervention was a protective factor. Higher TNM stage had a negative impact on the overall survival.
CONCLUSION: Specialized oral diagnosis did not directly impact disease-free survival and overall survival and did not influence the indication of surgery in oral cancer; however, it was associated with the diagnosis of early tumors and better prognosis.