anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a Chinese traditional medicine used for treating hysteromyoma and aims at providing a Chinese traditional medicine for treating hysteromyoma with quick action, good efficacy, simple and convenient method, and few side effects. The Chinese traditional medicine is a decoction decocted from the following crude drugs with the weight proportion: 8% - 16% of bittersweet, 8% - 16% of glabrous greenbrier rhizome, 8% - 16% of coix lachryma jobi, 8%-16% of scirpus maritimus, 8% - 16% of puccoon root, 8% - 16% of leafy twig of Chinese arborvitae, 8% - 16% of safflower and 8% - 16% of hedyotis diffusa. The Chinese traditional medicine is decocted into decoction according to the weight proportion of the formula, and one dose per day can be taken for two or three times. The lumps can be shrank or exterminated after clinical verification. All the crude drugs of the invention has wide source and can be collected in the southern region of the Yangtze River. The invention has the advantages of heat clearing and detoxifying, softening hardness to dissipate stagnation, activating blood circulation and dissipating blood stasis, diminishing inflammation, and few side effects.
These subjects will be healthy, pain-free adults and receive no intervention. Over the 8 week intervention period, participants in this group will be asked to maintain currently levels of physical activity, sedentary behaviors, and medication regimen.
Listening to one of two different specific music programs (Group A), which is composed for the treatment of depressive symptoms. The music is listened to during a period of 30 minutes in the morning and 30 minutes in the evening over 5 - 15 weeks.
Canrenone, a major (and active) metabolite of spironolactone, appears in human breast milk. Because spironolactone has been found to be tumorigenic in rats, a decision should be made whether to discontinue the drug, taking into account the importance of the drug to the mother. If use of the drug is deemed essential, an alternative method of infant feeding should be instituted.

Thiazides are excreted in human milk in small amounts. Thiazides when given at high doses can cause intense diuresis which can in turn inhibit milk production. The use of spironolactone and hydrochlorothiazide tablets during breast feeding is not recommended. If spironolactone and hydrochlorothiazide tablets are used during breast feeding, doses should be kept as low as possible.
The invention relates to a novel functional plant composition and an application thereof. The novel functional plant composition is prepared by mixing the specific parts of plants I and II or the extracts and functional components prepared by taking the specific parts as raw materials at a random ratio, wherein the plant I is leaves and flowers of at least one of the original plant or the variant plant (Potentilla arbuscula var.veitchii) of Potentilla fruticosa var. albicans and Potentilla glabra var. mandshurica Maxim in potentilla of the rose family; the plant II is roots, rhizomes and subterraneous stems of at least one of stachys sieboldii and rhizome of bear's-foot fern (in stachys of the labiatae familiy) and jerusalem artichoke and witloof (of the compositae family). The novel functional plant composition has the efficacies of preventing and treating cardiac-cerebral vascular diseases, metabolic diseases, degenerative diseases and digestive system diseases. The novel functional plant composition and processed products thereof can be used as the raw materials of the substitutional tea, common food, health food as well as foods and medicines with special medical uses.
The study recruited four demographically matched groups (age, sex ratio): individuals with AUD with and without a history of early trauma, and moderate drinkers with and without early trauma. Study procedures involved functional magnetic resonance imaging (fMRI), an eight-week outpatient treatment program, and a 90-day follow-up period. During fMRI sessions, participants engaged in a validated emotion provocation task, viewing stress, alcohol-cue, and neutral images while concurrent brain and stress hormone data are collected. Individuals with AUD completed baseline assessments, including multimodal neuroimaging, and then participated in an 8-week treatment program consisting of two sessions per week. This program integrated cognitive-behavioral techniques focused on emotion regulation with breathing-based stress management. Control participants completed baseline assessments including multimodal neuroimaging but did not receive any treatment. Following the treatment, participants with AUD were prospectively followed for 90 days, with remote follow-up interviews conducted at 14, 30, 90 days via video communication.
Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver (see CLINICAL PHARMACOLOGY, Pharmacokinetics). Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. On the basis of available data, no dosage adjustment is recommended for patients on these drugs.

Phenytoin, Carbamazepine, and Rifampicin: In patients treated with potent inducers of CYP3A4 (i.e., phenytoin, carbamazepine, and rifampicin), the clearance of ondansetron was significantly increased and ondansetron blood concentrations were decreased. However, on the basis of available data, no dosage adjustment for ondansetron is recommended for patients on these drugs.1,3

Tramadol: Although no pharmacokinetic drug interaction between ondansetron and tramadol has been observed, data from 2 small studies indicate that ondansetron may be associated with an increase in patient controlled administration of tramadol.4,5

Chemotherapy: Tumor response to chemotherapy in the P-388 mouse leukemia model is not affected by ondansetron. In humans, carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron.

In a crossover study in 76 pediatric patients, I.V. ondansetron did not increase blood levels of high-dose methotrexate.
A Manocept Platform prospective, open-label, multicenter, dose escalation, safety with PK and dosimetry study of injected Tc 99m tilmanocept in the detection of and assessment of localization to skeletal joints in subjects with and without active RA by SPECT imaging. All subjects will receive IV administration at one of 3 mass doses: 50 µg, 200 µg, or 400 µg. Within each mass dose group, subjects will receive Tc 99m tilmanocept labeled with one of 3 radiolabel doses: 1 mCi, 5 mCi, or 10 mCi.

All subjects will have a whole body planar SPECT scan. Subjects enrolled in Groups 1-9 will receive a whole body and planar hands scan followed by SPECT/CT scans on areas of interest post injection at 60 minutes ± 15 minutes and 180 minutes ± 15 minutes. Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed at 4 specified time points post injection: 15 ± 5 minutes, 60 ± 15 minutes, 180 ± 15 minutes and 18-20 hours. Planar hand scans will be collected at 60 ± 15 minutes and 180 ± 15 minutes post-injection. PK blood sampling will be performed before injection (within 15 minutes), immediately following injection (within 5 minutes) and at each scanning timepoint. Dosimetry tests will be performed at each scanning timepoint. PK of urine will be assessed through counts of the bladder wall obtained from cumulative quantitative planar imaging from radiation dosimetry.
The present invention provides an isolated human monoclonal antibody that binds specifically to human tissue factor pathway inhibitor (TFPI), wherein the antibody comprises: a) a human antibody heavy chain comprising: i. a CDR1 region with the amino acid sequence of FTFRSYGMS comprising a R30S or S35D substitution or both relative to SEQ ID NO: 1; ii. a CDR2 region with the amino acid sequence of SIRGSSSSTYYADSVKG comprising a S55R or S56G substitution or both relative to SEQ ID NO: 1; iii. a CDR3 region with the amino acid sequence of KYRYWFDY comprising a K99L substitution relative to SEQ ID NO: 1; and b) a human antibody light chain comprising: i. a CDR1 region with the amino acid sequence of SGDNLRNYYAH comprising a R28P or N29K substitution relative to SEQ ID NO: 2; ii. a CDR2 region with the amino acid sequence of YYDBNRPS comprising at least one substitution selected from the group consisting of Y48F and N51V and combinations thereof relative to SEQ ID NO: 2; iii. a CDR3 region with the amino acid sequence of QSWDDGVPV comprising at least one substitution selected from the group consisting of S89A, D91W, D92S, G93S and V94T and combinations thereof relative to SEQ ID NO: 2. Also provided are isolated human monoclonal antibodies as defined in claims 2-3. Furthermore, the present invention provides a pharmaceutical composition for treating deficiencies or defects in coagulation comprising said isolated human monoclonal antibodies.
Promoting Resilience in Stress Management (PRISM) is a 1:1, remotely delivered, resilience coaching program for adolescents with chronic illness, consisting of skill-building sessions in stress management, goal setting, cognitive re-framing, and benefit-finding. Sessions are held every 1-2 weeks for a total of 4 required and one optional session and each session lasts about 30-45 minutes.
AIMS: Critical limb ischemia (CLI) is an emerging public health threat and lacks a reliable score for predicting the outcomes. The Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping (ABCD-GENE) risk score helps identify patients with coronary artery disease who have cytochrome P450 2C19 (CYP2C19) polymorphism-related drug resistance and are at risk for cardiovascular adverse events. However, its application to CLI remains unknown. In this study, we aim to validate a modified ACD-GENE-CLI score to improve the prediction of major adverse limb events (MALEs) in patients with CLI receiving clopidogrel.
METHODS: Patients with CLI receiving clopidogrel post-endovascular intervention were enrolled prospectively in two medical centers. Amputation and revascularization as MALEs were regarded as the outcomes.
RESULTS: A total of 473 patients were recruited, with a mean follow-up duration of 25 months. Except for obesity, old age, diabetes, chronic kidney disease (CKD), and CYP2C19 polymorphisms were significantly associated with MALEs. Using bootstrap regression analysis, we established a modified risk score (ACD-GENE-CLI) that included old age (≥ 65 years), diabetes, CKD, and CYP2C19 polymorphisms. At a cutoff value of 8, the ACD-GENE-CLI score was superior to the CYP2C19 deficiency only, and the conventional ABCD-GENE score in predicting MALEs (area under the curve: 0.69 vs. 0.59 vs. 0.67, p=0.01). The diagnostic ability of the ACD-GENE-CLI score was consistent in the external validation. Also, Kaplan-Meier curves showed that in CYP2C19 deficiency, the ABCD-GENE and ACD-GENE-CLI scores could all differentiate patients with CLI who are free from MALEs.
CONCLUSIONS: The modified ACD-GENE-CLI score could differentiate patients with CLI receiving clopidogrel who are at risk of MALEs. Further studies are required to generalize the utility of the score.
An enhanced article which has a beneficial contact surface intended to allow bioabsorption of beneficial materials through the user's contact with the enhanced article in use. A functional or ornamental article which has at least one contact surface intended to come in contact with a human user includes a beneficial contact surface for covering the article's contact surface and providing a beneficial surface contact compound adapted to come in contact with a human user touching the article. The beneficial contact surface is connected to the article so that the contact surface of the article is covered by the beneficial contact surface. The presence of the beneficial surface contact compound in the beneficial contact surface means results in the exposure of the user's skin to the beneficial surface contact compound to allow absorption by the user. The article can be any functional or ornamental object which in its regular use comes in contact with a user's skin, including but not limited to such objects as a cellphone, doorknob, packaging, clothing, brushes, laptops and shower curtains. Also, a process by which articles can be converted into enhanced articles through addition of a beneficial contact surface which provides bioabsorption of beneficial materials added as contact surfaces for the articles through various techniques.
NEW MATERIAL:A 5,10-epoxidized previtamin D3 of the formula. USE:Useful as a medicine, e.g. a cancer eliminating agent, and having a powerful ability to induce the differentiation of human myelocytic leukemia HL-60 cells into granulocytes. PROCESS:Vitamin D3 is subjected to the reaction with a peroxide, e.g. tert-butyl hydroperoxide in the presence of molybdenum carbonyl [Mo(CO)6], to give the 5,10-epoxidized previtamin D3 of the formula. Dried benzene is used as the reaction solvent.
Soybean [Glycine max (L.) Merr.] is an important legume crop worldwide, which provides abundant plant protein and oil for human beings. Soybean mosaic virus (SMV) can cause serious damage to the yield and quality of soybean, but it is difficult to control SMV with chemicals, breeding SMV-resistant varieties has become the most effective way to control the disease. Therefore, it is important to identify SMV resistance genes from soybean resources and apply them to soybean breeding. In this study, the disease rates (DRs) of 219 soybean accessions to SMV strain SC7 in two environments were investigated. A high-density NJAU 355 K SoySNP array was used for genome-wide association study (GWAS) of DR. A 274 kb region on chromosome 15 (1,110,567 bp to 1,384,173 bp) was repeatedly detected in two environments. Six new significant single nucleotide polymorphisms (SNPs) on chromosome 15 were identified. Four of these six SNPs were located within two candidate genes, Glyma.15G015700 and Glyma.15G015800. The elite haplotype Glyma.15G015700Hap I with low DR exhibited strong resistance to SC7. The expression of Glyma.15G015700 in the SMV-resistant accession increased significantly after inoculation with SC7. Furthermore, most of the proteins predicted to interact with Glyma.15G015700 are heat shock proteins, which have been shown to be related to disease resistance. In summary, new SMV resistance loci and a new candidate gene, Glyma.15G015700, were identified and might be utilized in further soybean disease resistance breeding.
BACKGROUND: Paediatric vehicular hyperthermia (PVH) is the leading cause of non-crash vehicle-related death of children in the USA. Public health messaging is an important mitigation strategy, yet it is difficult to assess the effectiveness in reducing deaths. Here, we seek to better understand parent/caregiver perceptions on PVH to guide risk communication.
METHODS: This pilot study focuses on a subset of participants (n=127) from a national survey, comprising parents/caregivers who met specific eligibility criteria (ie, those who both drive and have children ≤5 years of age). Survey participants answered questions about the perceived severity of forgetting a child in a hot car and their susceptibility to doing so, with responses recorded on a 7-point Likert scale (1=strongly disagree and 7=strongly agree). : R : e : s : u : l : t : s : Our findings indicate that while on average (mean responses of 2.45 and 2.49) parents/caregivers did not consider themselves susceptible, they did acknowledge the severity (mean response of 6.12) of leaving a child unattended in a vehicle. The results suggest that because of this low perceived susceptibility, parents/caregivers are less likely to take protective actions aimed at preventing these incidents from happening.
CONCLUSIONS: Public health messaging on PVH should emphasise the universal risk to all parents/caregivers so as to foster greater awareness of the need to take protective actions. Furthermore, engaging secondary audiences such as teachers and healthcare professionals can amplify this message and offer concrete behavioural interventions to mitigate the risk of forgetting a child in a car.
Macrophages are the most abundant alternative immune cells in the tumor microenvironment (TME). The cross-talk between macrophages and tumor cells provides an important shelter for the occurrence and development of tumors. As an important information transfer medium, exosomes play an important role in intercellular communication. Nonetheless, how exosomal lncRNAs coordinate the communication between tumor cells and immune cells in hepatocellular carcinoma (HCC) is incompletely understood. We found that HCC exosomes-derived antisense RNA of SLC16A1(SLC16A1-AS1) promoted the malignant progression of HCC by regulating macrophage M2-type polarization. Mechanistically, the HCC exosomal SLC16A1-AS1 enhanced mRNA stabilization of SLC16A1 in macrophage by promoting the interaction between 3' untranslated regions (3'UTR) of SLC16A1 mRNA and heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1). As a lactate transporter, SLC16A1 accelerated lactate influx and then activated c-Raf/ERK signaling to induce M2 polarization of macrophages. Reciprocally, M2 macrophages secreted IL-6 to activate STAT3 and then induce METTL3 transcription in HCC cells, which increasing m6A methylation and stabilization of SLC16A1-AS1. In turn, the reciprocal SLC16A1-AS1/IL-6 signaling between HCC cells and M2 macrophages promoted the proliferation, invasion and glycolysis of HCC cells. Our study highlights that exosomal SLC16A1-AS1 acts as a signaling message that induces lactate-mediated M2 polarization of macrophages, and implies that SLC16A1-AS1 might be an applicable target for therapeutic treatment of HCC.
Background One-lung ventilation (OLV) is the foremost used technique of ventilation during thoracic procedures. Intraoperative lung separation can be managed by means of double-lumen endotracheal tube (DLT), bronchial blocker (BB), or nonintubated method. OLV is impeded by significant reduction in lung volume, decline in lung compliance at lateral decubital position, formation of intrapulmonary shunting and exposure of the dependent lung to ventilator-induced lung injury (VILI). In addition, patients receiving thoracic surgeries are more prone to developing acute lung injuries due to direct surgery-related trauma caused by instrumentation or manipulation of the lung tissues, hypoperfusion induced by hypoxic pulmonary vasoconstriction, and dysfunction of surfactant system. The non-dependent lung is injured by surgical manipulation and atelectrauma. Re-expansion of the collapsed non-dependent lung at the end of surgery inevitably results in systemic inflammatory response in the local and contralateral lungs, which in turn leads to biotrauma. Therefore, a significantly high pulmonary complication of up to 14-28.4% was reported in patients that received OLV surgery.

In the recent two decades, there is a major paradigm shift for mechanical ventilator support during operation by the introduction of intraoperative lung protective ventilation strategies. Some of these changes include a low tidal volume (Vt), moderate levels of positive end-expiratory pressure (PEEP), optimal driving pressure (∆P) and the appropriate use of lung recruitment maneuver. Intraoperative lung protective ventilation strategies have been shown to reduce post-operative pulmonary complications and improve overall clinical outcomes in intermediate and high-risk patients undergoing major abdominal surgery. Currently, however, there is a lack of clinical evidence in regard to appropriate protective-lung strategies during OLV. The optimal levels of intraoperative use of oxygen fraction, the ventilatory settings for volume and pressure variables during OLV and re-expansion phases for lung recruitment are debating. The main objective of this clinical study is to determine the optimal levels of volume-pressure dynamics during OLV and at the phase of recruitment of the independent lungs by achieving optimal lung compliance, gas exchange and hemodynamics.
NEW MATERIAL:A thiophene derivative shown by the formula I (A is group shown by the formula II or formula III). EXAMPLE:2-(1,2-Dibromo-2-nitroethyl)thiophene. USE:A fungicide, antiseptic, antifungal agent, etc. Showing strong antimicrobial action on bacteria and fungi. PROCESS:A compound shown by the formula IV is brominated with bromine in a solvent at 10-80 deg.C for 30min-3hr, to give a compound shown by the formula I when A is group shown by the formula II. This compound is reacted with a dehydrohalogenating agent such as caustic potash, etc. at room temperature for 2-5hr, to give the compound shown by the formula I when A is group shown by the formula III.
Selaginellaceae, originated in the Carboniferous and survived the Permian-Triassic mass extinction, is the largest family of lycophyte, which is sister to other tracheophytes. It stands out from tracheophytes by exhibiting extraordinary habitat diversity and lacking polyploidization. The organelle genome-based phylogenies confirmed the monophyly of Selaginella, with six or seven subgenera grouped into two superclades, but the phylogenetic positions of the enigmatic Selaginella sanguinolenta clade remained problematic. Here, we conducted a phylogenomic study on Selaginellaceae utilizing large-scale nuclear gene data from RNA-seq to elucidate the phylogeny and explore the causes of the phylogenetic incongruence of the S. sanguinolenta clade. Our phylogenetic analyses resolved three different positions of the S. sanguinolenta clade, which were supported by the sorted three nuclear gene sets, respectively. The results from the gene flow test, species network inference, and plastome-based phylogeny congruently suggested a probable hybrid origin of the S. sanguinolenta clade involving each common ancestor of the two superclades in Selaginellaceae. The hybrid hypothesis is corroborated by the evidence from rhizophore morphology and spore micromorphology. The chromosome observation and Ks distributions further suggested hybridization accompanied by polyploidization. Divergence time estimation based on independent datasets from nuclear gene sets and plastid genome data congruently inferred that allopolyploidization occurred in the Early Triassic. To our best knowledge, the allopolyploidization in the Mesozoic reported here represents the earliest record of tracheophytes. Our study revealed a unique triad of phylogenetic positions for a hybrid-originated group with comprehensive evidence and proposed a hypothesis for retaining both parental alleles through gene conversion.