anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional Chinese medicine lotion for treating the infectious wound. The wound infection is the process that pathogenic microorganisms cause the regional tissues to have the inflammatory tissue reactions including redness, swelling, fever, pain and the like through local or blood circulation. Therefore, the traditional Chinese medicines with the efficacies of clearing away heat and toxic materials as well as removing the necrotic tissue and promoting granulation, such as radix ampelopsis, franchet groundcherry, sculellaria barbata, abrus cantoniensis hance, hypericum uralum, Impatiens chinensis Linn., cacumen biotae, Lindernia ciliata (Colsm.) Pennell, spina gleditsiae, ardisia crenata leaves, and Polygonum runcinatum Buch.-Ham. or P.Runcinatum Buch.-Ham.var. Sinense Hemsl., are selected to prepare the traditional Chinese medicine lotion. The clinical test proves that the total effective rate achieves 96.7%, and the curative effect is good.
Participants will be guided by a research assistant through a single silent sitting session, which will serve as a time-matched control. During the sitting session, participants will watch a 20-minute video clip while sitting silently. Similar to the aerobic exercise group, participants' heart rate will be continuously monitored via a Polar OH1 heart rate monitor. Following the sitting session, participants will rest for 5 minutes to match the exercise group before starting the post-assessments.
Combined modality therapy may prove of benefit for patients with AIDS-related primary CNS lymphoma.

Patients who upon staging workup are found to be without systemic involvement undergo one cycle of chemotherapy with cyclophosphamide, doxorubicin, vincristine, dexamethasone, and G-CSF. Cyclophosphamide, doxorubicin, and vincristine are administered intravenously on day 1. Dexamethasone is administered intravenously on day 1 and then orally thereafter with gradual discontinuation. G-CSF is administered subcutaneously daily beginning on day 2 and continuing for a total of 10 days or until blood counts have recovered to an acceptable level. Patients with evidence of cancer cells in their cerebrospinal fluid (CSF) will receive chemotherapy with intrathecal cytarabine twice weekly until no further evidence of cancer cells is found in the CSF, then once weekly for 6 weeks, and then monthly for 10 months. Seven to ten days following completion of one cycle of chemotherapy, patients undergo radiotherapy to the brain at a dose of 2.5 Gy daily for 5 days per week for approximately 4 weeks. Total dose to the whole brain and meninges is 30.0 Gy in 12 fractions, and total dose to the primary boost volume is 10.0 Gy in 4 fractions. During therapy, blood is drawn weekly and brain scans are performed every 3-12 weeks. An initial CSF sample will be obtained by lumbar puncture.
PROBLEM TO BE SOLVED: To obtain a new polynucleotide useful for screening of antibacterial compounds and for, e.g. treatment or diagnosis of a chlamydia trachomatis infection, and being much the same as a nucleic acid encoding a LysS polypeptide comprising a specific amino acid sequence. SOLUTION: This polynucleotide is a new isolated one which comprises e.g. a polynucleotide having at least 70% of the sameness as a polynucleotide encoding a polypeptide comprising the amino acid sequence of the formula or anther polynucleotide having at least 70%, of the sameness as anther polynucleotide encoding the same mature polypeptide as one expressed by a lysS gene contained in a chlamydia trachomatis strain, and is useful for screening of antibacterial compounds and for, e.g. treatment or diagnosis of a chlamydia trachomatis infection. The polynucleotide is obtained by probing a typical library of a clone of a chromosome DNA of chlamydia trachomatis by using a partial sequence-derived labeled oligonucleotide.
The novel compound 1,3-bis-(5-sulphobenzimidazolyl-2) benzene and/or a salt thereof, is prepared by sulphonating 1,3-bis-(benzimidazolyl-2) benzene, e.g. with chlorosulphonic acid in H2SO4 and, if desired, is converted to salts such as the sodium, potassium, ammonia and mono-, di- and tri-ethanolamine salts. 1,3-Bis-(benzimidazolyl-2) benzene is prepared by reacting o-phenylene diamine with isophthalic acid or a reactive derivative thereof, e.g. the acid chloride, amide or isophthalic aldehyde, in the presence of a condensation agent such as polyphosphoric acid. The material can also be obtained by the reduction of isophthalic acid di-o-nitranilide.ALSO:A composition, capable of absorbing U.V. radiation, comprises as the active ingredient 1, 3-bio-(5-sulpho-benzimidazolyl-2) benzene and/or a salt thereof, and an inert physiologically acceptable carrier suitable for topical application.  The compound itself or the sodium, potassium, ammonium, or mono-, di- or tri-ethanolamine salts are particularly preferred. These compounds may be incorporated into solutions, jellies, creams or sprays for application and may be in the presence of conventional additives such as perfumes, skin-conditioning agents and insect repellents as well as other U.V. absorbing compounds such as the sodium salts of 2-phenylbenzimidazole-5-sulphonic acid and 3, 4-dimethylphenylglyoxylic acid or 4-phenylbenzophenone and 4-phenylbenzophenone-2\sv-carboxylic acid isooctyl ester.  The novel compounds, of the sulphonic acid class, shield the skin from harmful U.V. radiation of short wavelengths.
Early enteral nutrition (EN) is consistently recommended as first line nutrition therapy in critically ill patients since it favorably alters outcome, providing both nutrition and non-nutrition benefits. However, critically ill patients receiving mechanical ventilation (MV) are at risk for regurgitation, pulmonary aspiration, and eventually ventilator-associated pneumonia (VAP). EN may increase these risks when gastrointestinal (GI) dysfunction is present. Gastric residual volume (GRV) is considered a surrogate parameter of GI dysfunction during the progression of enteral feeding in the early phase of critical illness and beyond. About 62% of critically ill patients receive enteral nutrition (EN) and in patients on MV, enteral feeding was connected to a threefold increase in the development of VAP.

A new surveillance definition of ventilator-associated events (VAE) was introduced by the National Healthcare Safety Network (NHSN) in 2013 to identify patients who develop complications of MV. It outlines the various events in a step-by-step fashion, beginning with ventilator-associated complications (VAC), moving on to infectious complications (IVAC), and finally VAP. According to the NHSN, VAEs occur within 9% to 40% of mechanically ventilated patients
Participants will receive onartuzumab 10 milligrams per kilogram (mg/kg) intravenous (IV) infusion + mFOLFOX6 (oxaliplatin, folinic acid, and 5-fluoruracil) regimen. Participants will receive a maximum of 12 cycles (each cycle is 14 days) of mFOLFOX6 with onartuzumab. Participants whose disease has not progressed after 12 cycles of mFOLFOX6 with onartuzumab will continue treatment with onartuzumab until disease progression, unacceptable toxicity, or death.
Maintaining an appropriate acid-base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect. Current Western diets are characterized by a high DAL, due to large amounts of animal protein and processed foods. A chronic low-grade metabolic acidosis can occur following a Western diet and is associated with increased morbidity and mortality. Nutritional advice focusing on DAL, rather than macronutrients, is gaining rapid attention as it provides a more holistic approach to managing health. However, current evidence for the role of DAL is mainly associative, and underlying mechanisms are poorly understood. This review focusses on the role of DAL in multiple conditions such as obesity, cardiovascular health, impaired kidney function, and cancer.
Invention applies to the medicine and pharmaceutical industry. The invention aims to increase the efficiency of treatment. The tea consists of the following components in mass percentage: buck-bean leaves (Folia Menyanthidis) - 33.4, peppermint leaves (Mentha piperita) - 33.3 and knot-grass (Polygonum aviculare) -33.3. The tea containing components are separately pulverised by a hammer crusher and the fine particles sifted. Components are mixed in a drum mixer until the mixture becomes homogeneous. For treatment, the herb mixture infusion is used. Consumption of the proposed tea makes the bile secrete more effective and improves its chemical composition.
PURPOSE: The study aimed to describe the dermoscopic features of pityriasis rosea among patients attending the skin clinic at Mbarara Regional Referral Hospital.
PATIENTS AND METHODS: A hospital-based cross-sectional descriptive study conducted for a 6-month period in the skin clinic of MRRH in Southwestern Uganda. Data were collected from consecutively recruited patients using structured questionnaires. Patients with a clinical diagnosis of pityriasis rosea were examined using a dermoscope and subsequently sent for KOH and TPHA tests to rule out fungal skin infection and secondary syphilis, respectively, and then received routine care at the skin clinic.
RESULTS: There were 54 patients with pityriasis rosea seen. Dermoscopy was done on a total of 162 lesions of which 19 were herald patches, 51 were truncal lesions, 52 on the extremities while 40 were on the face and neck regions. Common dermoscopic features consisted of a violaceous background noted in 145 (89.51%), white scales in 161 (99.38%), diffuse scale distribution in 57 (35.19%), perifollicular scale type in 61 (37.65%), and brown-dotted pigmentary changes in 66 (40.74%). Other unique findings noted in a few lesions were cloudy structures, petechial spots, erosions, and punched out pits.
CONCLUSION: Most prevalent dermoscopic features included: a violaceous background, white scales, diffuse scale distribution, perifollicular scale type, brown-dotted pigmentary changes with no visible blood vessels nor follicular changes. Other unique less frequently seen findings were cloudy structures, petechial spots, erosions, and punched out pits.
Standard circumcision under general anaes-thesia with ultrasound-guided penile nerve block.Penile nerve block patients will be positioned in the supine position. An ultrasound-guided technique will be used as described previously. A linear probe will be placed transversely at the base of the penis while an assistant applies caudal traction to the penis. The penile neurovascular sheath is then located just above the corpus cavernosum. The dorsal penile nerve, dorsal penile artery and penile deep dorsal vein are visualized deep to Buck's fascia. Using a sterile technique, a 25 gauge, 1,5 inch needle will be inserted in-plane from lateral to medial so that the needle tip is placed into the penile neurovascular sheath, 0,1 mL/kg (max 4 mL) of ropivacaine 0,25% will be injected under real-time ultrasound guidance while retracting the needle so that the local anaesthetic solution spreads bilaterally filling the neurovascular space.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to curative-prophylactic agents normalizing functions of genital organs, arresting amenorrhea, development of neurological and osteoporosis symptoms in preclimacteric or climacteric periods. The proposed agent comprises glutamic acid or its pharmaceutically acceptable salts, glycine, calcium acid succinate, magnesium acid succinate, zinc acid fumarate, tocopherol acetate and ammonium succinate. Invention provides effect of agents normalizing functional disorders in menstrual cycle and estrogen background. Agent provides arresting in development of neurological and osteoporous pathological disorders, sleep disorder, depression in preclimacteric and climacteric period, to treat pathological amenorrhea, to prevent neurological symptoms of premenstrual syndrome, enhances energetic status of body. Agent shows antioxidant and adaptogenic properties also, it reduces weather dependence, normalizes endocrine system state, elicits hypoglycemic effect and reduces intensity of climacteric bleedings. EFFECT: enhanced and valuable medicinal properties of agent. 10 cl
NEW MATERIAL:A polyaminedithiol compound of formula I (R1, R2, R11 and R12 are lower alkyl; R21 is H or lower alkyl; R3 and R13 are H or nitrogen- containing organic group, but at least one of the groups is the nitrogen- containing organic group). EXAMPLE:N-(2-Mercapto-2-methylprophyl)-N'-(isoprophylaminomethyl-2- mercaptopropyl)ethylenediamine. USE:The compound of formula I produces a chelate bond with a radioactive metal element to form a chelate useful as a radioactive diagnostic agent. A complex thereof with Tc-99m is especially useful as a brain local blood flow- imaging agent. PREPARATION:For example, a compound of formula II (Pro is a mercapto- protecting group) is condensed with CO(Cl)2 to form a compound of formula III, which is reduced to convert the carbonyl groups thereof into methylene groups. The protecting groups of produced compound of formula IV are removed to provide a compound of formula I wherein all of R1, R2, R11 and R12 are methyl; R21 is H.
BACKGROUND: Observational studies that reveal an association between periodontitis (PD) and ankylosing spondylitis (AS) exist. However, observational research is prone to reverse causality and confounding factors, which make it challenging to infer cause-and-effect relationships. We conducted a two-sample Mendelian randomization (MR) study to examine the causal relationship between the genetic prediction of PD and AS.
METHODS: In our study, single-nucleotide polymorphisms (SNPs) were defined as instrumental variables (IVs). The genetic association with PD came from the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) consortium, wherein 17353 cases of European ancestry and 28210 controls of European ancestry were included in this study. The genetic association with AS from the Neale Laboratory Consortium included 337,159 individuals from the United Kingdom, with 968 cases and 336,191 controls. MR analysis was mainly performed using the inverse-variance weighted (IVW) method. In addition, the robustness of the study findings was assessed using sensitivity, pleiotropy, and heterogeneity analyses.
RESULTS: Eighteen independent SNPs with P-values significantly smaller than 1 × 10- 5 were used as IV SNPs for PD, while 39 independent SNPs with P-values significantly smaller than 1 × 10- 5 were used as IV SNPs for AS. The results of the IVW method revealed no causal association between PD and AS (odds ratio = 1.00, 95% confidence interval: 0.99953 to 1.00067, P = 0.72). The MR-Egger method did not support the causal association between PD and AS. It is unlikely that horizontal pleiotropy distorts causal estimates based on sensitivity analysis. No significant heterogeneity was observed in the Q test. The ''leave-one-out'' analysis demonstrated that the robustness of our results was unaffected by eliminating any of the IVs. Likewise, no significant causative effect for AS on PD was observed in the inverse MR analysis.
CONCLUSIONS: The study results do not support shared heritability or a causal association between PD and AS.
The investigators will assess the residents' knowledge, attitudes, and skills prior to and after the PACTS curriculum administration at half the sites (Early Intervention Group). Evaluation results in the Early Intervention Group will be compared to the Delayed Intervention (Active Comparator) group at time Period 2.
Participants receive Cognitive behavioral therapy (CBT). Participants will receive 4 one hour CBT treatments.
Obstructive sleep apnea (OSA) is prevalent amongst surgical patients and associated with an increased incidence of perioperative complications. The gold standard treatment for moderate-to-severe OSA is positive airway pressure (PAP) therapy. Practice guidelines by the American Society of Anesthesiologists and the Society of Anesthesia and Sleep Medicine have recommended preoperative screening for OSA and consideration of initiation of PAP therapy for patients with severe OSA. These guidelines, developed mainly by the consensus of experts, highlight the adverse impact of OSA on postoperative outcomes and recommend the use of postoperative PAP in surgical patients with moderate to severe OSA. Since the development of these guidelines, there has been an increase in the number of publications regarding the efficacy of PAP therapy in surgical patients with OSA. Our review provides an update on the existing literature on the efficacy of PAP therapy in surgical patients with OSA. We focus on the postoperative complications associated with OSA, potential mechanisms leading to the increased risk of postoperative adverse events, and summarize the perioperative guidelines for the management of patients with OSA, evidence supporting perioperative PAP therapy, as well as limitations to PAP therapy and alternatives. An update on the existing literature of the efficacy of PAP therapy in surgical patients with OSA is critical to assess the impact of prior guidelines, determine when and how to effectively implement PAP therapy, and target barriers to PAP adherence in the perioperative setting.
Cell competition is a mechanism for cellular quality control based on cell-cell comparisons of fitness. Recent studies have unveiled a central and complex role for cell competition in cancer. Early tumors exploit cell competition to replace neighboring normal epithelial cells. Intestinal adenomas, for example, use cell competition to outcompete wild-type epithelial cells. However, oncogenic mutations do not always confer an advantage: wild-type cells can identify mutant cells and enforce their extrusion through cell competition, a process termed "epithelial defense against cancer". A particularly interesting situation emerges in metastasis: supercompetitive tumor cells encounter heterotypic partners and engage in reciprocal competition with diverging outcomes. This article sheds light on the emerging complexity of cell competition by highlighting recent studies that unveil its context dependency. Finally, we propose that tissue histomorphology implies a crucial role for cell competition at tumor invasion fronts particularly in metastases, warranting increased attention in future studies.
OBJECTIVE: The aim of this study was to evaluate the efficacy of a self-assessment questionnaire for hirsutism using the latest cutoff values recommended by the Endocrine Society (ES) for Latin-American women and by the European Society for Human Reproduction and Embryology (ESHRE).
SUBJECT AND METHODS: Female premenopausal outpatients (n = 188) completed a self-assessment questionnaire, scoring hair presence across the nine areas evaluated by the modified Ferriman-Gallwey (mFG) scale. The results were compared with clinician-assessed scores rated independently by two trained physicians. Scores in the Hirsuta questionnaire, derived from self-assessment of five areas of the mFG scale, were also evaluated.
RESULTS: The ethnic composition of the sample was as follows: 23.1% white, 25.8% black, 48.9% mixed, and 2.1% other backgrounds (Indigenous, Asian). The participants had age and BMI of (mean ± standard deviation) 33.7 ± 9.9 years and 29.8 ± 7.21 kg/m2, respectively. The most common areas of excessive hair growth were the chin, upper and lower abdomen, and thighs. Relative to clinician-assessed mFG scores, self-assessed mFG scores had an accuracy of 80% using ES criteria for hirsutism diagnosis, with a sensitivity of 95.45%, specificity of 56.25%, positive predictive value of 30.10%, and negative predictive value of 98.40%. Self-assessed mFG had lower accuracy (71%) for diagnosing hirsutism when the ESHRE criteria were applied.
CONCLUSIONS: Self-assessed mFG had low specificity, limiting its application. The results of this study do not support the use of the self-assessed mFG or Hirsuta scores for diagnosing hirsutism in a clinical setting, although both scoring systems may be useful for screening hirsutism in epidemiological studies.
Primary IgA nephropathy is a common glomerular disease, heterogeneous in its clinical presentation. Historically considered to assume a benign course, we actually know that up to 40% of the cases progress to end stage renal disease at 20-30 years. Clinical and basic research has now allowed to understand the pathophysiology of this disease, to predict its course and to treat progressive forms more aggressively. This article summarizes classical treatments and recent therapeutic additions (sparsentan and targeted-release budenoside), which demonstrated remarkable efficacy. Complement inhibitors and B cells or plasma cells inhibitors to target aberrant IgA production have already emerged as new potential treatments. Collectively these advances may open a new therapeutic era in the management of this disease.
The clinical trial included the parients who participated in the protocol ERAS since 2011, who uderwent esophagectomy with simultaneous reconstruction. The parients had benign or malignant esophageal diseases. The ERAS protocol consisted of components of perioperative recovery. The number of patients until now has reached 400 patients. During trial there was modifications of aspects of ERAS protocol such as a rejection of nasogastric tube or cervical drenage. The role of multidisplinary team is the main success of the result of the implemented ERAS protocol.
BACKGROUND: The aging global population forecasts a significant rise in severe trauma cases among individuals aged 65 and above. Frailty emerges as a paramount predictor of post-traumatic outcomes, surpassing age and trauma severity indices. Despite this, scant attention is given to the trajectory of elderly patients post-intensive care unit (ICU) stay following severe trauma, justifying this study. The objective of this study was to analyze trajectories (frailty, place of residence) following a major trauma requiring an ICU stay.
MATERIALS AND METHODS: An observational cohort study was conducted, leveraging data from a level 1 trauma center spanning 2018 to 2023. Inclusion criteria included elderly patients aged 65 and above admitted to the ICU for severe trauma. Data encompassed demographic profiles, trauma severity scores, clinical parameters, and frailty assessments sourced from the Traumabase database.
RESULTS: Among 293 patients included 190 were non-frail, frailty was correlated with elevated mortality rates (114 (38.9%) at 6 months), heightened incidence of traumatic brain injuries, and notable declines in post-traumatic autonomy. Only 39.2% of patients had resumed residence at home six months post-injury, with a conspicuous trend towards institutionalization, particularly among frail individuals.
CONCLUSION: This study highlights the role of frailty in determining the outcomes of elderly patients following severe trauma. Frailty is associated with higher mortality, increased rates of institutionalization, and a decline in functional status. These results highlight the importance of assessing frailty in the trajectory of severely injured patients over the age of 65 years-old.