anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention discloses a kind of Kanggu-Zengsheng tablet Film coated tablets and preparation method thereof, and the Kanggu-Zengsheng tablet Film coated tablets refers to that coating water-soluble thin film coating material by mist on the surface of Kanggu-Zengsheng tablet plain piece is formed by Kanggu-Zengsheng tablet tablet；The method for preparing Kanggu-Zengsheng tablet Film coated tablets includes preparing the technical process such as film coating liquid, film coating；Kanggu-Zengsheng tablet Film coated tablets prepared by the present invention has the advantage that compared with Kanggu-Zengsheng tablet in the prior art and 1. uses auxiliary material few, reduce production cost；2. it is broken to reduce tablet, yield is improved, the production time is substantially reduced, is conducive to environmental protection；3. improving the mode of appearance of tablet, humidity resistance is good, increases the stability of drug；4. increasing the dissolution rate of tablet, it is disintegrated drug rapidly, it is rapid-action；5. manufactured drug expands target user, especially suitable diabetic is taken；6. being conducive to quality by improving quality standard and controlling.
PROBLEM TO BE SOLVED: To handle needed information at appropriate timing in accordance with the flow of an examination operation. SOLUTION: In a step S1, patient information and examination request information are inputted and recorded. In a step S2, control that displays the patient information and the examination request information inputted in the step S1 is performed. In a step S4, examination performance is controlled, and an image related to examination is photographed and recorded while associated with the patient information and the examination request information. In a step S5, examination performance information including medicines, apparatus and materials used in the step S4 and conducted procedures, etc., is inputted, and control that associates the examination performance information with the patient information and the examination request information and records the examination performance information is performed.  In a step S6, examination results information including opinions, diagnoses, etc., about the results of the examination performed in the step S4 is inputted and recorded while associated with the patient information and the examination request information.
The invention relates to a traditional Chinese medicine composition for preventing and treating fur-bearing animal pasteurellosis. The traditional Chinese medicine composition is prepared from reed stem, semen coicis, rhizoma phragmitis, peach kernel, ephedra, apricot kernel, gypsum, common bletilla tuber, the root bark of the peony tree, rhizoma fagopyri dibotryis and licorice root. The traditional Chinese medicine composition can be powder. A preparation method of the traditional Chinese medicine composition comprises the following steps: (1) weighing the following traditional Chinese medicines according to the amount in a formula: 15-25 parts of reed stem, 6-15 parts of semen coicis, 8-10 parts of rhizoma phragmitis, 4-6 part of peach kernel, 5-10 parts of ephedra, 5-9 parts of apricot kernel, 8-11 parts of gypsum, 10-15 parts of common bletilla tuber, 5-10 parts of the root bark of the peony tree, 5-10 parts of rhizoma fagopyri dibotryis and 5-7 parts of licorice root; (2) crushing all the traditional Chinese medicines and sieving by using a sieve of which the size is 60-100mesh; (3) mixing for 10-15 minutes to obtain traditional Chinese medicine powder; (4) subpackaging the traditional Chinese medicine powder with bags containing 100g each to obtain a finished product. The traditional Chinese medicine composition disclosed by the invention can be used for effectively preventing and treating the fur-bearing animal pasteurellosis and is above 95% in cure rate. The prescription has the effects of clearing away heat and toxic materials, promoting apocenosis, relieving carbuncle, freeing lung, relieving asthma, cooling blood and stopping bleeding.
Understanding how gender norms affect parents' communication of genetic and cancer risk information to their children can enable healthcare professionals to better facilitate cascade genetic testing. We conducted a qualitative study with semi-structured interviews to determine social factors associated with parents carrying the BRCA1/2 pathogenic variants who communicated cancer prevention practices to their children. Thirty adult carriers (23 women, 7 men) participated in the interviews. All had at least one child aged over 8 years old. Interview topics included their discovery of the variants, their relationship to their body and to the risk of cancer, as well as disclosure to and subsequent communication with their children after testing positive for BRCA1/2. The interviews were analyzed qualitatively, and the major themes identified were identified and compared. We described the roles played by the BRCA1/2 carriers and their partners in communicating cancer prevention practices to their children, from how they managed their own risk of cancer after testing positive, to how they disclosed the risks linked to these pathogenic variants to their children. We also described their involvement in the process of their children going for professional genetic consultation. Gender norms lead women to be more attentive than men to their own health and that of their loved ones. In the context of the transmission of genetic information to children, gender differences in behavior are reinforced by perceptions of the risks of BRCA1/2 variants and women's related health management practices. Cancer prevention is shaped by complex links between gender norms and health management practices.
Over the course of the year, we have observed that recombinant leptin has the potential to act as an insulin-sensitizer in subjects with lipoatrophy and leptin deficiency. The exact mechanisms of this effect are not known. We would like to test whether leptin will work as an insulin-sensitizer in a situation where the mechanism of insulin resistance is known, namely in a situation where there is a known defect on the insulin receptor. This will allow us to learn if leptin can overcome a receptor defect by activating some of the down-stream molecules in insulin signaling cascade.

We would like to begin exploring this question in two patients with mutations on their insulin receptor, who are in need of improved treatment. In fact, in these two patients, the conventional therapeutic options have not provided adequate control of blood sugar levels. Furthermore, the circulating leptin concentrations in these two patients are lower than the 15th percentile of normal population. Therefore, a strategy to achieve physiological concentrations of leptin hormone using recombinant leptin (A100, recombinant methionyl-human leptin) will be justified.

We also plan to keep the initial observation period short. Since we have observed insulin-sensitizing effects of leptin in lipoatrophy within 4 months, we will limit the initial treatment period to 4 months. The regime will be similar to the regimen used in lipoatrophic patients. The starting dose will be 50% of replacement dose and this will be incrementally increased to 200% replacement dose within the course of two months. The medication will be administered subcutaneously in two divided doses. Plasma glucose concentrations and HbA1c are designated as primary outcome measures. Data on the effects of leptin hormone on appetite, insulin secretion and sensitivity and other pituitary hormones will also be collected as pilot data. At the end of 4 months, we will make a decision to continue therapy and to broaden the study by opening recruitment to other similar patients.
Group Exercise: community setting. This arm will involve attendance at community based group exercise classes that are taught by senior physical fitness instructors. These classes are designed specifically for older adults. Exercise frequency will be 2 times per week, for a total of 12 visits over the 6-week research period. These exercise classes will be attended at local community senior centers which cater to the needs of older adults. The subjects can self-select which particular exercise class they prefer to attend, based upon their level of fitness and physical function.
Reintubation, which occurs after planned extubation, is a relevant consequence of respiratory failure after extubation. The early use of noninvasive pressure support ventilation averted respiratory failure after extubation in patients at increased risk. However patient tolerance to the technique is a critical factor determining its success. One of the key factors determining tolerance to Non Invasive Ventilation (NIV) is optimal synchrony between the patient's spontaneous breathing activity and the ventilator's settings, known as patient ventilator interaction. Optimal patient-ventilator synchrony during NIV can prove very difficult to achieve due to the presence of leaks, the type of interface which can interfere with various aspects of ventilator function. Patient ventilator synchrony during NPSV can be compromised when using conventional pneumatic triggering, with the ventilator-delivered inspiratory support starting after the patient's inspiratory effort. The switch from inspiration to expiration (cycling-off) should, ideally, coincide with the end of the patient's inspiratory effort. However greater asynchrony at the end of inspiration, with the ventilator cycling off either too early or too late compared to the end of the patient's inspiratory effort can be observed during NPSV. A possible solution is to replace the pneumatic triggering with neural triggering and cycling off using the diaphragm electrical activity (Eadi). Neurally adjusted ventilatory assist (NAVA) uses the electrical activity of the diaphragm to control the timing and pressure of the ventilation delivered. The ventilator is triggered, limited and cycled-off directly by Eadi. The Eadi is measured by a multiple array oesophageal electrode. The array of bipolar electrodes can be mounted on a feeding tube, which is routinely introduced in critically ill patients.
Percutaneous coronary intervention with Provisional stenting technique. Stenting of the side branch was required if TIMI flow was \<3, or ≥ type B dissection after kissing balloon inflation.
The presence of harmful and toxic elements in nickel-based dental casting alloys can result in significant issues in oral tissues and an increase in cellular toxicity. However, this invention addresses these challenges by eliminating the use of beryllium (Be). Several constituents such as,Al,Ti,Fe and Nb were added into the base which was made of Ni-Cr-Mo.This formulation is specifically designed to enhance biocompatibility properties, reaching over 97% (cellular toxicity less than 2.5%) of the dental casting alloy. To improve the coefficient of thermal expansion, niobium (Nb) and molybdenum (Mo) were selected in the alloy design. Additionally, chromium (Cr), molybdenum (Mo), and nickel (Ni) were employed in the melting process to enhance corrosion and mechanical properties. The entire melting and casting process occurs in a single melting stage within a pressure range of 5 to 15 millibars.
Doses of TBio-6517 will be administered by direct injection into tumor(s) x 4 in combination with pembrolizumab beginning at Day 9 given every 3 weeks for up to 24 months in patients with microsatellite stable colorectal carcinoma (MSS-CRC). Booster injections of TBio-6517 are permitted for up to 24 months.
Viable animal cell-containing material is preserved by adding to it an aqueous solution containing from 0.1% up to the isotonic limit of the animal material, preferably between 0.5 and 1.5%, of at least one of the following carbohydrate materials as stabilizing agent: a sugar alcohol of the formula CnHn+2(OH)n (where n is a whole number from 4 to 7) a cyclitol of formula C6H6(OH)6 or a methyl ether thereof a sugar alcohol of the formula C6H5(OH)6CH3, C6H6(OH)4, C6H8(OH)4 or C6H5O(OH)5, together with a hydrogen ion buffering agent. Stabilizing agents mentioned: erythritol, threitol, arabitol, ribitol, xylitol, mannitol, sorbitol, dulcitol, iditol, sedoheptitol, mesoinositol or isomer thereof, pinitol, quebrachitol, conduritol, scyllitol, epimesoinosose, dextra-quercitol, betitol and mytilitol. The solution preferably contains from 0.025 to 1.5% by weight of alkali metal citrate, phosphate, acetate or carbonate as buffering agent, a nutrient sugar such as glucose or fructose in an amount of from 0.125 to 0.75%, and a colloid stabilizer such as gelatine, agar, guar gum, tragacanth, gum arabic, dextrin or gum ghatti in an amount of from 0.1 to 1.0%. A preferred stabilizing agent comprises from 70%-30% sorbitol and 30%-70% mannitol. Animal cell-containing materials mentioned are: animal semen, blood cells, bone marrow, muscle, artery and other body tissues and cells. In the preservation of semen, the semen preferably is diluted with from 10 to 200 parts of the aqueous stabilizing solution to give a diluted semen having an osmotic pressure between 200 and 350 milliosmoles the solution may include, in addition to the substances specified above, whole milk, skim milk, glycerol, egg yolk, lecithin, lipoproteins, and antibiotics such as streptomycin and penicillin. According to an example, a diluent for semen was prepared by admixing 30 parts by weight of egg yolk with 25 parts of whole milk, heat treated by raising the temperature to 90 DEG C. for two minutes. To this was added 0.25 part gelatin, 0.5 part D-glycitol, 0.5 part D-mannitol, 0.5 part D-fructose, 0.1 part potassium citrate, 0.1 part sodium citrate and 0.1 part potassium dihydrogen phosphate. Forty-five parts of water were added. Streptomycin was added in the amount of 500 micrograms per milliliter of solution along with 500 I.U. of penicillin per milliliter of solution. The solution had a final pH of 6.4 and an osmotic pressure of 300 milliosmoles. Motility tests on the semen of bulls and other animals indicated the preservative effect of this solution. A further example is directed to the preservation of blood.
The invention discloses a hybrid antibacterial peptide, a preparation method and application thereof, wherein the amino acid sequence of the hybrid antibacterial peptide is shown as SEQ ID NO. 1. The hybrid antibacterial peptide molecular-P has broad-spectrum antibacterial activity, has antibacterial activity to most gram-positive bacteria and gram-negative bacteria with different degrees, and particularly has good antibacterial activity to escherichia coli, salmonella and staphylococcus aureus. Compared with the original antibacterial peptide, the antibacterial activity of the antibacterial peptide after heterozygosis on common pathogenic bacteria is obviously enhanced. The antibacterial agent has the characteristics of heat stability and acid stability, and has good application prospects in aspects of food preservation, disease prevention and treatment, animal feed additives and the like. The hybrid peptide molecular peptide-P in the invention is a small molecular peptide, has thermal stability, can be kept at a high temperature of 100 ℃ for 45min, and can meet the high temperature requirement of feed pelletization.
Couples assigned to the experimental group will be included in a three-week program, attending a self-efficacy theory-based childbirth preparation program in groups of 4-5 couples, scheduled according to their availability. At the end of the sessions, brochures reflecting the educational content will be given to the couples to read at home. These couples will also receive routine care provided at the hospital, which includes standard antenatal follow-up and information about pregnancy and childbirth during physician visits. After the completion of the training, couples will receive weekly phone calls until their estimated due date to reinforce the educational content.
Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a serious threat to wheat (Triticum aestivum L.) production. Narrow genetic basis of common wheat boosted the demand for diversified donors against powdery mildew. Aegilops tauschii Coss (2n = 2x = DD) and emmer wheat (2n = 4x = AABB), as the ancestor species of common wheat, are important gene donors for genetic improvement of common wheat. In this study, a total of 71 Ae. tauschii and 161 emmer wheat accessions were first evaluated for their powdery mildew resistance using the Bgt isolate E09. Thirty-three Ae. tauschii (46.5%) and 108 emmer wheat accessions (67.1%) were resistant. Then, all these accessions were tested by the diagnostic markers for 21 known Pm genes. The results showed that Pm2 alleles were detected in all the 71 Ae. tauschii and only Pm4 alleles were detected in 20 of 161 emmer wheat accessions. After haplotype analysis, we identified four Pm4 alleles (Pm4a, Pm4b, Pm4d, and Pm4f) in the emmer wheat accessions and three Pm2 alleles (Pm2d, Pm2e, and Pm2g) in the Ae. tauschii. Further resistance spectrum analysis indicated that these resistance accessions displayed different resistance reactions to different Bgt isolates, implying they may have other Pm genes apart from Pm2 and/or Pm4 alleles. Notably, a new Pm2 allele, Pm2S, was identified in Ae. tauschii, which contained a 64-bp deletion in the first exon and formed a new termination site at the 513th triplet of the shifted reading frame compared with reported Pm2 alleles. The phylogenetic tree of Pm2S showed that the kinship of Pm2S was close to Pm2h. To efficiently and accurately detect Pm2S and distinguish with other Pm2 alleles in Ae. tauschii background, a diagnostic marker, YTU-QS-3, was developed, and its effectiveness was verified. This study provided valuable Pm alleles and enriched the genetic diversity of the powdery mildew resistance in wheat improvement.
The invention relates to an externally-applied medicinal wine for rheumatisms. The externally-applied medicinal wine is prepared from an immersion wine and immersion traditional Chinese medicines. The externally-applied medicinal wine is characterized in that the externally-applied medicinal wine comprises the following components, by weight, 10-15 parts of Eucommia ulmoides, 10-15 parts of Sichuan pawpaw, 5-15 parts of Radix Angelicae Pubescentis, 5-15 parts of safflower, 5-15 parts of lumbricus, 5-15 parts of white peony root, 5-15 parts of Chinese angelica, 10-20 parts of Panax Notoginseng, 3-6 parts of centipede, 10-20 parts of Chinese Taxillus Twig, 10-15 parts of Zoacys Dhumnade, 10-20 parts of Radix Clematidis, 10-20 parts of Millettia dielsiana and 5-10 parts of unprepared rehmannia root; and the immersion wine adopts 2000ml of a 40-60DEG rice (white) wine. The preparation method of the externally-applied medicinal wine comprises the following steps: putting the above raw materials in a container, sealing, and placing the container in a shade place at normal temperature for about 30 days to obtain the externally-applied medicinal wine. The externally-applied medicinal wine has the advantages of simple preparation, low price, abundant raw material sources and good curative effects. The combined medicines in the invention have the main effects of blood circulation promoting, blood stasis removing, muscle and tendon relaxing, and collateral activating, and are especially suitable for symptoms comprising rheumathritis, periomethritis, strains, neuralgia, headaches, rheumatoid diseases, hemiplegia, numbness in hands and feet, bruises and sprains, hyperosteogeny, hypertrophy in cervical vertebras and lumbar vertebras, and the like.
Limb muscle is responsible for physical activities and myogenic cell migration during embryogenesis is indispensable for limb muscle formation. Maternal obesity (MO) impairs prenatal skeletal muscle development, but the effects of MO on myogenic cell migration remain to be examined. C57BL/6 mice embryos were collected at E13.5. The GeoMx DSP platform was used to customize five regions along myogenic cell migration routes (myotome, dorsal/ventral limb, limb stroma, limb tip), and data were analyzed by GeomxTools 3.6.0. A total of 2224 genes were down-regulated in the MO group. The GO enrichment analysis showed that MO inhibited migration-related biological processes. The signaling pathways guiding myogenic migration such as hepatocyte growth factor signaling, fibroblast growth factor signaling, Wnt signaling and GTPase signaling were down-regulated in the MO E13.5 limb tip. Correspondingly, the expression levels of genes involved in myogenic cell migration, such as Pax3, Gab1, Pxn, Tln2 and Arpc, were decreased in the MO group, especially in the dorsal and ventral sides of the limb. Additionally, myogenic differentiation-related genes were down-regulated in the MO limb. MO impedes myogenic cell migration and differentiation in the embryonic limb, providing an explanation for the impairment of fetal muscle development and offspring muscle function due to MO.
OBJECTIVE: The objective of the study is to evaluate the factorial structure and the psychometric qualities of the Pandemic Fatigue Scale among the Quebec adult population.
METHOD: The data analyzed come from a web survey conducted in October 2021 among 10 368 adults residing in Quebec. The scale's factor structure and invariance by gender, age and language used to complete the questionnaire were tested using confirmatory factor analyses. Convergent and divergent validity were also assessed. Finally, the reliability of the scale was estimated from the alpha and omega coefficients.
RESULTS: The analyzes suggest the presence of a bidimensional structure in the sample of Quebec adults with informational fatigue and behavioral fatigue. The invariance of the measure is noted for sex, for age subgroups and for the language used for the questionnaire. The results of convergent and divergent validity provide additional evidence for the validity of the scale. Finally, the reliability of the scale scores is excellent.
CONCLUSION: The results support the presence of a bidimensional structure as in the initial work of Lilleholt et al. They also confirm that the scale has good psychometric qualities and that it can be used among the adult population of Quebec.
Sham-RIPC will consist of setting a tourniquet to donor thigh without inflating it and keeping it in place for 35 min. Sham-RIPC-intervention will be performed twice: First after brain death and second time before procurement procedure.
Intervention: Hybrid Assistive Limb (HAL); gait training in combination with conventional training. Training with the exosceleton Hybrid Assistive Limb (HAL) is performed in 1 session per day, 4 days per week during 4 weeks. Time for each session is individualised but does not exceed 60 minutes/session (effective time). Training with HAL is performed in combination with body-weight support system and on a treadmill. The training program is performed by 2 physiotherapists, who have been trained in the HAL method.
Conditioning from Day -9 to Day -1. Stem cells given on Day 0. Busulfan, alemtuzumab, cyclophosphamide, fludarabine, cyclosporine, stem cell infusion.
Students assigned to the experimental group will be divided into groups of 6-9. 3 psychoeducation sessions will be held with each group once a week for a total of 3 weeks. Group sessions are estimated to last between 60-75 minutes. Psychoeducational content based on Leventhal's Self-Regulation Model was prepared. In the first stage, cognitive bases of dysmenorrhea, in the second stage, strategies to cope with dysmenorrhea, and in the third stage, the effectiveness of coping strategies in dysmenorrhea will be discussed. In the second stage, the participants will be taught the progressive muscle relaxation exercise, which is among the strategies to cope with dysmenorrhea. Sessions will be held online.