anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Objective: To analyze the effect of single pigtail bile duct stents without lateral wings bile duct drainage after removal of common bile duct stones in endoscopic retrograde cholangiopancreatography (ERCP). Methods: Patients who underwent ERCP and implantation of a single pigtail bile duct stent for choledocholithiasis in Cholelithic Center of East Hospital Affiliated to Tongji University from January 2019 to September 2023 were retrospectively selected and divided into lateral wingless group (without the lateral wing) and lateral wing group(with the lateral wing) according to whether the lateral wings of the single pigtail bile plastic stents were preserved. The patients were followed up for 1 to 3 months. The stent detachment rate at 2 days, 1 week and 1 month, as well as the incidence of postoperative complications at 1 week and 1 month after ERCP were compared between the two groups. Results: A total of 402 patients were included, including 177 males and 225 females, aged 32-83 (58±12) years. There were 215 cases in the lateral wingless group and 187 cases in the lateral wing group. The stent detachment rate in the lateral wingless group was higher than that in the lateral wing group at 2 days after ERCP [12.6% (27/215) vs 5.9% (11/187), P=0.022]. The stent detachment rate in the lateral wingless was higher than that in the lateral wing group at 1 week after ERCP [87.0% (187/215) vs 25.1% (47/187), P<0.001]. The stent detachment rate in the lateral wing group was higher than that in the lateral wing group at 1 month after ERCP [97.2% (206/215) vs 67.3% (126/187), P<0.001]. The incidence of postoperative complications at 1 week after ERCP revealed no statistical significance between the two groups[(10.7% (23/215) vs 8.6% (16/187), P>0.05]. The incidence of postoperative complications at 1 month after ERCP in the lateral wingless group was lower than that in the lateral wing group [0.9% (2/215) vs 9.6% (18/187), P=0.001]. Conclusion: After the removal of choledocholithiasis with ERCP, bile is drained by a single pigtail bile duct stent with lateral removal, which has a high rate of natural shedding and a low incidence of complications.
The invention provides methods of screenir.g for a compound for promoting wakefulness in a mammal. The method is practiced by providing a compound that is a PrRP receptor agonist and determining the ability of the compound to promote wakefulness. Also provided by the invention are methods of screening for a compound for promoting sleep in a mammal. The methods are practiced by providing a compound that is a PrRP receptor antagonist and determining the ability of the compound to promote sleep. In addition, the invention provides a method of promoting wakefulness in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor agonist. The invention further provides a method of promoting sleep in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor antagonist.
Disclosed herein are RFID enabled medical device systems including an RFID emitter configured to provide an interrogation signal that impinges on an RFID tag associated with a medical device to trigger a response signal. The response signal can indicate and presence or absence of the medical device proximate to the RFID emitter. A console communicatively coupled to the RFID emitter can determine, record, and analyze procedural or usage information about the medical device. Further information about the medical device can be encoded within the response signal and provided to the console. Console settings can be automatically updated based on the information within the response signal. Additional modalities are also contemplated including optical image recognition of medical device kits. Further AR viewers can provide image overlays to guide a user in correct procedure. Procedural compliance can be automatically recorded and monitored.
A computer implemented system for generating an electronic record of a patient clinical encounter in clinical chart format for submission for review by a health care reviewing organization. The system includes a selection interface module adapted to facilitate the selection of one or more reasons for the patient clinical encounter and/or one or more diagnoses. The system also includes a verification module for determining an authorization level for the diagnosis and/or reason for the encounter by referring to data in identified fields. The verification module determines the authorization level prior to the submission of the clinical record via a web browser on the client side to a server computer. The selection interface module facilitates selection of criteria prompts in a prompt pop-up button list by the display of a clickable navigator text field. The navigator field describes prompts selected to meet criteria for the diagnosis and/or reason for the encounter.
BACKGROUND: The fluid balance is a critical parameter in intensive care units (ICU) as it provides information about the patient's volume status. However, the accuracy of fluid balance measurements is often compromised due to the complexity and repetition of actions involved. Additionally, the fluid balance could be recalculated for insensible fluid loss. Weighing is an alternative method to estimate the patient's volume status. Built-in scales in beds make patient weighing easier and less time-consuming, allowing clinicians to intervene more quickly on existing treatments.
AIM: This study compares fluid balance, and body weight changes over time in ICU patients. Furthermore, it seeks to determine the degree of congruence between the fluid balance corrected for insensible fluid loss and daily body weight in ICU patients.
METHODS: A single-center observational study was conducted in an ICU of a university hospital. All consecutive patients admitted to a bed with an integrated weighing scale were eligible. Exclusion criteria were (1) body weight ≥254,4 kilograms; (2) oral nutrition; (3) a flush catheter or balance; (4) only a single weight measurement; (5) delta body weight change of ≥5kg in 12 hours. Weights and fluid balances were obtained every 12 hours.
RESULTS: We obtained 2282 measurements (n = 187 patients). The correlation between weight and fluid balance was weak (r = 0.274). After adjusting the fluid balance for insensible fluid loss, the correlation remained weak (r = 0,268). Bland Altman analysis revealed a wide confidence interval for both the fluid balance and corrected fluid balance versus weight.
CONCLUSION AND IMPLICATIONS OF KEY FINDINGS: This study shows a weak correlation between weight and fluid balance. Therefore, when monitoring the volume status in the ICU, fluid balance and weight should both be taken into account. This two-pronged approach is crucial because it provides more control over erroneous fluid balance or weighing measurements.
Patients will receive an injection of indocyanine green (ICG) 1 day prior to surgery. Near infrared fluorescence imaging (NIFI) will be used to identify pulmonary nodules during the surgical biopsy and/or resection procedure.
The Mediterranean-DASH diet intervention for Neurodegenerative Delay (MIND in Stroke patients is designed to test the effects of a 2-3 year intervention of a hybrid of the Mediterranean and DASH diets, called MIND on 500 older patients, without dementia who are hospitalized for acute stroke who are discharged home following hospitalization. The MIND diet has the same basic components of the DASH and Mediterranean diets, such as emphasis on natural plant based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetable and berries as well as food component servings that reflect the nutrition dementia evidence. In this study we will test the effects of a 2- to 3-year intervention of the MIND diet (3 months of delivered meals followed by dietary and general stroke health counseling) versus usual post-stroke care (3 months delivered self-selected meals followed by general stroke health counseling) on change on cognitive outcomes over 24 to 36 months. Biological effects of the MIND diet will be assessed by measurement of brain macro and microstructural integrity in 300 trial participants randomly selected participants. Other biochemical markers will be assessed in the entire group of 500 participants including: plasma Abeta42/beta40, brain derived neurotropic factor (BDNF) and plasma markers of oxidative stress and inflammation. The trial will examine potential effect mediators and modifiers by a number of cardiovascular risk factors, AD biomarkers and biological mechanisms. The proposed study has 3 recruitment sites, Rush University Medical Center, University of Chicago, and Advocate Christ Hospital all located in Chicago.
PURPOSE:To obtain a row Rehmanniae rhizoma capable of withstanding the long-term storage, by freeze-drying the raw Rehmanniae rhizoma to keep the active constituents contained therein without loss. CONSTITUTION:A raw Rehmanniae rhizoma dug and collected in the autumn is washed with wafer, drained, sliced and preliminarily frozen in a refrigerator at -20--30 deg.C. The resultant preliminarly frozen raw Rehmanniae rhizoma is then transferred to the interior of a freeze-dryer and freeze-dried to remove the moisture at 1mm.Hg or below under slight heating over a whole day and night and give the aimed freeze-dried Rehmanniae rhizoma. The Rehmanniae rhizoma is a plant belonging to the family Scrophulariaceae, and obtained from the rhizome of Rehmannia glutinosa Lib. var. purpurea Makino as it is or the rhizome of the plant belonging to the same genus Rehmannia or steaming the rhizome, and incorporated into SHAKUKANZOTO (a decoction containing a licorice), HACHIMIGAN (a pill containing the Rehmanniae rhizoma, etc.), OGONTO (a decoction containing Scutellaria radix, etc.) and SHIMOTSUTO (a decoction containing Japanese angelica root, Cnidii rhizoma, Peony root, etc.) as an antianemic, tonic and antipyretic agent.
The invention discloses an officinal dendrobium processing method. In processing, fresh officinal dendrobium is subjected to pre-sieving so that officinal dendrobium pre-sieving is realized and officinal dendrobium sorting workload is greatly reduced. In officinal dendrobium baking, the officinal dendrobium is repeatedly turned so that the officinal dendrobium can be uniformly heated and officinal dendrobium quality is guaranteed. Straw is used as an officinal dendrobium hooping material, is easily available, has a low price, does not influence officinal dendrobium drug properties and does not produce environmental pollution. Officinal dendrobium is dried in a sieving warehouse so that the officinal dendrobium can be uniformly dried by a sieving-type drying method and thus officinal dendrobium coking is prevented in drying. A burning old newspaper beats officinal dendrobium so that officinal dendrobium color is improved and an officinal dendrobium value is increased.
Major depressive disorder (MDD) is a highly prevalent condition associated with substantial disease burden and economic costs. Still, it often remains undetected and untreated, which in turn increases the likelihood of a chronic course, treatment resistance and rising healthcare costs. One solution to address early detection and disease burden could be widely accessible depression screening. Our previous trial in cardiac patients provides first evidence that depression screening combined with written individual-targeted feedback on the screening results improves depression severity and encourages greater patient participation and engagement in mental health. To amplify these effects in a broader setting, the internet-based DISCOVER randomized controlled trial (RCT) now aims at addressing affected but yet undetected individuals on the internet. In order to evaluate the effect of feedback in this setting, a total of 1076 individuals reporting elevated levels of depression (PHQ-9 score ≥ 10) will be randomized into three groups. They either receive a) no feedback (control group), b) standardised or c) tailored feedback on their depression screening results. The primary hypothesis is that feedback reduces depression severity six months after screening compared to no feedback. The secondary hypothesis is that tailored feedback is more efficacious as compared to standard feedback. Futher outcomes are guideline-based depression care, depression-related help-seeking behaviour, a health economic evaluation, clinical outcomes (somatic symptom severity and anxiety), health-related quality of life, illness beliefs, intervention acceptance, depression diagnosis and adverse events.
HIV and intimate partner violence are intersecting, mutually-reinforcing epidemics that significantly affect African American women, particularly women in the U.S. South. African American women face some of the highest rates of both HIV and intimate partner violence among U.S. women, and these burdens are most pronounced in the South. African American surviving intimate partner violence may experience forced, condom less sex, which increases the risk of HIV acquisition. Pre-exposure prophylaxis has the potential to be the most innovative HIV prevention strategy, however it remains underutilized by African American women and residents of the South. In order to reduce African American women's HIV acquisition risk in the South, effective HIV prevention interventions need to concurrently address relationship safety and HIV acquisition risks. Developing effective interventions to tackle this HIV-related disparity among African American women is essential to reach national HIV goals.Therefore, the proposed research aims to develop, test, and evaluate a Pre-Exposure Prophylaxis Implementation Toolkit for clinical staff in community healthcare settings in the South. The Toolkit will be evaluated using the Reach, Effectiveness-Adoption, Implementation, Maintenance (RE-AIM). The Toolkit will serve the dual purpose of increasing Pre-Exposure Prophylaxis uptake among African American women in the South while addressing intimate partner violence as a potential Pre-Exposure Prophylaxis barrier. This research project will include a formative evaluation (i.e., reach stage), including key informant interviews with clinical staff at the partnering community healthcare clinics (N=10), and six focus groups with African American women at risk for HIV acquisition (i.e., Pre-Exposure Prophylaxis-eligible; %50 intimate partner violence-exposed). The qualitative data from the formal evaluation will inform the development of the Pre-Exposure Prophylaxis Implementation Toolkit, including detailed curriculum and supporting materials. The Toolkit will be pilot tested in two community healthcare clinics using a nonrandomized waitlist control design employed at the clinic-level. Clinic 1 will receive the Toolkit; and after the 8-month data is collected, Clinic 2 will receive the Toolkit. Changes in Pre-Exposure Prophylaxis uptake and retention in care will be assessed at the clinic level from 8-months before and after the Toolkit is implemented (i.e., effectiveness stage). To examine these effects at the clinic-level, a series of interrupted time series analyses will be conducted. This approach allows us to analyze population changes as opposed to individual change. To yield a moderate effect size with a power=.80 and alpha =.05, a sample size of at least 8 timepoints are needed. Following the Toolkit's implementation, four focus groups with clinical staff will be conducted to assess barriers and facilitators (i.e., adoption stage). Lastly, key informant interviews with clinical staff (N=20) will be conducted to assess fidelity of the Toolkit's components.
The invention provides a preparation method and application of a human superoxide dismutase hSOD1 mutant, and relates to the technical field of bioengineering. Providing a coding protein of a human superoxide dismutase hSOD1 mutant, which has an amino acid sequence shown as SEQ ID NO. Mt1SOD1 aa; provides an Mt1SOD1 gene for encoding the protein, which has a nucleotide sequence shown as SEQ ID NO. Mt1SOD1. The invention takes human hSOD1 as a template, obtains the gene of the hSOD1 mutant Mt1SOD1 (E25G, P29T, E101V, C112S) through gene mutation, and recombines human superoxide dismutase hSOD1 mutant Mt1SOD1 protein; the problem of heterogeneity is solved in application. And has high activity and high stability, and provides a new way for developing novel functional anti-aging cosmetics and series products and developing other anti-aging products such as functional foods and anti-aging medicines.
Patients should use RHINOCORT AQUA Nasal Spray at regular intervals since its effectiveness depends on its regular use. Patients may note an improvement in nasal symptoms within 10 hours of first using RHINOCORT AQUA Nasal Spray. Maximum benefit may not be achieved until approximately 2 week after initiation of treatment [see Dosage and Administration (2)].

Patients should take the medication as directed and should not exceed the prescribed dosage. The patient should contact the physician if symptoms do not improve after two weeks, or if the condition worsens. Patients who experience recurrent episodes of epistaxis (nosebleeds) or nasal septum discomfort while taking this medication should contact their physician. For proper use of RHINOCORT AQUA Nasal Spray and to attain maximum improvement, the patient should read and follow the accompanying patient information carefully. Do not use RHINOCORT AQUA Nasal Spray after the labeled number of sprays have been used (does not include priming) or after the expiration date shown on the carton or bottle label.
The invention relates to the field of cosmetics, and particularly relates to a composition with a moisturizing effect and a cosmetic containing the composition. A composition comprises Lonicera japonica Thunb, Scutellaria baicalensis Georgi, Aloe vera, Arnica Montana Thunb root, and centella asiatica. A higher stratum corneum moisture measurement indicates a higher stratum corneum moisture content of the skin. After the product to be tested is used, the water content of the horny layer in a product testing area is obviously improved, and each testing time point has obvious difference compared with that before the product is used; there was no significant change in stratum corneum water content in the placebo zone. The lower the transepidermal water loss (TEWL) measurement, the more complete the skin barrier function. After the product to be tested is used, the TEWL value of the product testing area is in a descending trend, and the TEWL value of the blank control area is in a slow ascending trend. In the clinical moisturizing efficacy test for 4 hours, 20 subjects did not have any adverse reaction.
One of the critical unmet medical needs in schizophrenia is the treatment for cognitive deficits. However, the neural circuit mechanisms of them remain unresolved. Previous studies utilizing animal models of schizophrenia did not consider the fact that patients with schizophrenia generally cannot discontinue antipsychotic medication due to the high risk of relapse. Here, we used multi-dimensional approaches, including histological analysis of the prelimbic cortex (PL), LC-MS/MS-based in vivo dopamine D2 receptor occupancy analysis for antipsychotics, in vivo calcium imaging, and behavioral analyses of mice using chemogenetics to investigate neural mechanisms and potential therapeutic strategies for working memory deficit in a chronic phencyclidine (PCP) mouse model of schizophrenia. Chronic PCP administration led to alterations in excitatory and inhibitory synapses, specifically in dendritic spines of pyramidal neurons, vesicular glutamate transporter 1 (VGLUT1) positive terminals, and parvalbumin (PV) positive GABAergic interneurons located in layer 2-3 of the PL. Continuous administration of olanzapine, which achieved a sustained therapeutic window of dopamine D2 receptor occupancy (60-80%) in the striatum, did not ameliorate these synaptic abnormalities and working memory deficit in the chronic PCP-treated mice. We demonstrated that chemogenetic activation of PV neurons in the PL, as confirmed by in vivo calcium imaging, ameliorated working memory deficit in this model even under clinically comparable olanzapine treatment which by itself inhibited only PCP-induced psychomotor hyperactivity. Our study suggests that targeting prefrontal PV neurons could be a promising therapeutic intervention for cognitive deficits in schizophrenia in combination with antipsychotic medication.
Non-compliance is a limiting factor for success of occlusion therapy for amblyopia (lazy eye) in childhood. It is responsible for approximately 1% of the adult population being unable to read with the amblyopic eye. The researchers used electronic monitoring of compliance to investigate predictors and a remedy for non-compliance.

Methods: In a prospective randomised controlled trial, compliance was measured for one week every three months during 30 months in newly diagnosed amblyopic children in The Hague, Frankfurt and Leicester. The family's social-economic and ethnic background was assessed through a questionnaire. Children were randomised to receive either an educational cartoon story explaining, without text, the rationale for treatment to the child with reward stickers and an information sheet, or a picture to colour. All received standard orthoptic care by a treating orthoptist, who was unaware of the randomisation. The electronic device and educational programme were distributed via home-visits by researchers. The primary outcome measure was percentage of compliance (realised/prescribed occlusion time). The secondary outcome measure was influence of social-economic, ethnic and clinical factors on compliance.
PURPOSE: A metal nanoparticle is provided to show stability in an aqueous solution and high absorbance within a near-infrared ray area, thereby being used in hyperthermia therapy and photothermal therapy through cancer cell or macrophage targeting ability. CONSTITUTION: A nanocomposite contains: metal nanoparticles; and a biocompatible polymer containing a functional group with a metal ion reduction potential. The polymer surrounds the metal nanoparticles. The metal nanoparticles have absorbance at a near-infrared ray area and have a triangular or hexagonal prism form. A method for preparing the nanocomposite comprises the step of reacting the biocompatible polymer and a metal precursor in an aqueous solvent. [Reference numerals] (AA) Strongly stir at 95°C; (BB) Pyrenyl dextran
The present disclosure provides systems and methods that leverage machine-learned models in conjunction with online data to monitor and detect the spread of a disease, such as, for example, a communicable illness. In one example, a computing system can include or otherwise leverage a machine-learned disease detection model. The computing system can input search engine data and, optionally, location data respectively associated with a first plurality of users into the machine-learned disease detection model. The computing system can receive identification of a second plurality of users predicted to have the disease as an output of the machine-learned disease detection model. The second plurality of users can be a subset of the first plurality of users. The computing system can identify one or more locations associated with elevated levels of the disease based at least in part on the location data respectively associated with at least the second plurality of users.