anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cardiovascular disease (CVD) causes one in three deaths reported each year in the United States. Strategies derived from patient-centered outcomes research (PCOR) that address CVD risk factors can greatly reduce the burden of CVD. Primary care practices must transform to deliver a higher level of PCOR evidence-based prevention to decrease cardiovascular risk. PCOR interventions that emphasize patient-centered care including self-management support, team-based care, improved information systems, and active quality improvement have been shown to be effective. Practices often require assistance integrating new programs into clinical operations. Practice facilitation has been shown to enhance implementation of new programs for patients with chronic disease in primary care. Other methods of practice support, including academic detailing, collaborative learning sessions, and health information technology assistance, have also been shown to be effective, by themselves and in combination with practice facilitation. Patient involvement may also aid practice transformation. Increasingly, practices are actively including patients as part of the change process through the creation of patient advisory councils and including patients in practice quality improvement teams. Another method of patient involvement to inform implementation of evidence-based care is the Boot Camp Translation process, in which patients collaborate with primary care clinicians, staff members, and community members to translate best practices into culturally and community relevant implementation at the local level. However, while these efforts have had considerable success, no study has looked at the incremental value of adding patient engagement strategies to the more standard approaches to practice transformation listed above. This project would implement the Southwest Health Extension Program to Enhance Research Dissemination (SHEPERD) as a cooperative program to build primary care practice capacity for quality improvement, change management, and implementation of PCOR findings in small and medium size primary care practices in Colorado and New Mexico, with an initial focus on cardiovascular care. It also would conduct a cluster randomized trial with an external matched cohort control group to examine the Reach, Effectiveness, Adoption, Implementation, and Maintenance of two approaches to practice transformation to implement PCOR interventions for reducing cardiovascular risks in primary care practices, comparing the impact of 1) a standard practice transformation support intervention (including practice facilitation, practice assessment with feedback, HIT assistance, academic detailing, and collaborative learning sessions) to 2) an approach that adds patient engagement activities (including patient advisory councils and boot camp translation) as part of the practice transformation support. This project will provide critical information regarding the added value of patient engagement in practice transformation efforts and will also result in a network of practices across the region with increased capacity for practice transformation and implementation of PCOR findings.
BACKGROUND: Fast-conducting atrial fibrillation misinterpreted as ventricular tachycardia is the leading cause for inappropriate shocks in patients with implantable cardiac defibrillators (ICD). These inappropriate shocks are associated with significant morbidity and mortality and cause great discomfort and stress.
CASE PRESENTATION: We report the case of a patient with ischemic cardiomyopathy, permanent atrial fibrillation, and a single-chamber DF-1 ICD implanted for the primary prevention of sudden cardiac death, who presented for multiple inappropriate internal shocks due to very fast-conducting atrial fibrillation, which was mislabeled as ventricular fibrillation by the ICD. Since the patient was under maximal atrioventricular nodal blocking medical therapy (beta-blockers and digitalis) and we didn`t find any reversible causes for the heart rate acceleration, we opted for rate control with atrioventricular node ablation. To counteract the risk of pacing-induced cardiomyopathy in this patient who would become totally pacemaker-dependent, we successfully performed left bundle branch area pacing. Because the patient`s ICD had a DF-1 connection and the battery had a long life remaining, we connected the physiological pacing lead to the IS-1 sense-pace port of the ICD. The 6-month follow-up showed an improvement in left ventricular function with no more inappropriate shocks.
CONCLUSIONS: Left bundle branch area pacing and atrioventricular node ablation in patients with an implantable single-chamber DF-1 defibrillator and fast-conducting permanent atrial fibrillation is a cost-efficient and very effective method to prevent and treat inappropriate shocks, avoiding the use of an additional dual-chamber or CRT-D device.
PURPOSE:To obtain a bacterium protecting agent useful as a medicine for protecting in vivo transfer of Staphylococcus aureus from intestinal canal in lowering of bacterium protecting function of the intestinal canal, e.g. in carrying out total parenteral nutrition. CONSTITUTION:This bacterium protecting agent consists of a combination of a component composed of specific nucleic acids and/or their pharmacologically permissible salts, e.g. typically the component composed of inosine, cytidine, GMP, uridine and thymidine, especially containing these nucleic acids in molar ratios of 4:4:4:3:1. This bacterium protecting agent protects in vivo transfer of Staphylococcus aureus from intestinal canal in lowering of bacterium protecting function of intestinal canal, e.g. in carrying out total parenteral nutrition.
This single blinded safety study will consist of two study arms and include 10 males each (18-35 years). One arm will include participants with normal weight and one with obesity. After a placebo run-in period, all subjects will be given porous silica three times daily, with increasing dose up to 9 grams/day (Phase 1). Subjects with obesity continued the study with highest dose for additional 10 weeks (Phase 2).

The participants will have weekly contacts during with the representative for the study (PI or other research staff). Clinical examinations, and blood sampling will be performed day 1, 7, 14, and 21. Faeces and morning urinary sampling day 1, and 21. Information regarding eating habits, sleep patterns, living conditions and gastrointestinal health were obtained from written forms and orally. If gastrointestinal adverse events would occur after increased dosage, the study staff will adapt the dosage protocol to facilitate adherence.
BACKGROUND: Respiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co-circulation and interaction between viruses is critical to prevention and management. We use > 10-year active surveillance in the Valencia Region to assess seasonality and co-circulation.
METHODS: Over 2010-2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real-time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS-CoV-2 and non-SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co-detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation.
RESULTS: Most viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December-February, as did HCoV and SARS-CoV-2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co-infection. Multiple viruses were found in 4% of patients, with more common co-detection in children under 5 (9%) than older ages. Influenza co-detection was generally observed infrequently relative to expectation, while RSV co-detections were more common, particularly among young children.
CONCLUSIONS: We identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co-detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co-detection, meriting further study.
The disclosed systems and methods include providing, to a client device associated with a user, a plurality of input prompts in accordance with a first time resolution. Embodiments include receiving, from the client device, individual data comprising responses to the plurality of input prompts. The individual data represents at least (i) a first symptomfactor of the user, and (ii) a first symptom of the user. Embodiments include determining, based at least in part on receiving the individual data, a first strength of a statistical association between the first symptom factor and the first symptom for the user. Embodiments include determining that the first strength exceeds a first threshold strength of association. Embodiments include responsive to determining that the first strength exceeds the first threshold strength of association, providing a refined input prompt to the client device that (i) relates to the first symptom factor and (ii) reduces the first time resolution to a second time resolution.
PURPOSE: A composition containing adipose-derived stromal vascular fraction(AD-SVF) for regenerating endothelial cells is provided to induce the growth of vascular endothelial cells and to prevent or treat impotence. CONSTITUTION: A composition for regenerating endothelial cells contains adipose-derived stromal vascular fraction(AD-SVF) as an active ingredient. The endothelial cells are vascular endothelial cells. The composition induces the growth of the vascular endothelial cells of corpus cavernosum. The erection is analyzed by expression analysis of corpus cavernosum. A vascular endothelial cell-specific marker is PECAM-1. The AD-SVF is derived from epididymal adipose tissues. A composition for preventing or treating impotence contains the composition as an active ingredient.
PURPOSE:The titled remedy comprising sakyomicin A as an active ingredient. CONSTITUTION:A retrovirus infections disease containing sakyomicin A shown by the formula s an active ingredient. Retrovirus infectious diseases include acquired immune deficiency syndrome, adult T-cell leukemia, etc. The compound shown by the formula is readily obtained by cultivating a mold capable of producing sakyomicin A and purifying. Administration is orally or parenterally carried out and powder, granule, injection liquid for internal use, tablet, suppository, ointment, cream, drop, etc., may be cited as a dosage form. 0.01-10mg/kg, preferably 0.1-5mg/kg is orally or parenterally administered. The compound shown by formula inhibits reverse transcriptase of retrovirus, shown inhibitory actions on growth of HTLV-III, a cause virus of AIDS and is effective against retrovirus infectious diseases such as AIDS, etc.
The invention relates to a traditional Chinese medicine syndrome type classification method based on a graph convolution neural network. Combines two traditional Chinese medicine diagnosis and treatment logics of syndrome differentiation treatment and state identification to realize automatic classification of traditional Chinese medicine symptoms to traditional Chinese medicine syndrome types. The model provided by the invention consists of three modules, namely, a graph construction module, a graph convolution module and a classifier. Firstly, constructing a prescription chart by using the traditional Chinese medicine knowledge; then, applying graph convolution on the prescription knowledge graph; and finally, classifying different syndrome types by adopting a perceptron classifier. The model adopts the traditional Chinese medicine relationship to establish a graph structure, and performs relation representation learning between symptoms and state elements based on graph convolution, thereby realizing more accurate syndrome type classification. The invention explores the relationship among the traditional Chinese medicine symptoms, the state elements and the syndrome types by constructing a symptom-state element-symptom graph structure, realizes the automatic classification of the syndrome types based on a graph convolution neural network, provides technical support for the traditional Chinese medicine diagnosis and treatment, and realizes the computer-aided traditional Chinese medicine diagnosis and treatment.
IMPORTANCE: More than 40% of US adults have obesity, which increases the risks for multiple chronic diseases and premature mortality. Historically, nonsurgical interventions often have not led to sufficient weight loss and maintenance to improve health, but highly effective antiobesity medications (AOMs) have recently become available, and additional effective therapeutics are under development. Given that most medical care for adults with obesity is delivered in primary care settings, guidance for integrating weight-management approaches is needed.
OBSERVATIONS: Lifestyle interventions can lead to a mean weight loss of 2% to 9% of initial weight at 1 year and increase the likelihood of weight loss of 5% or more, but weight regain over time is common even with continued treatment. Adjunctive treatments, including AOMs and surgical approaches, can lead to larger, more sustained weight loss and improvements in numerous obesity-associated medical conditions. Highly effective AOMs, including nutrient-stimulated hormone-based therapies, induce mean weight loss of 15% or more. Barriers to intervention, including access to care, have a disproportionate influence on populations most affected by obesity and its consequences.
CONCLUSIONS AND RELEVANCE: Primary care clinicians play a vital role in the assessment, management, and support of patients with obesity. With careful clinical assessment and shared decision-making, a flexible treatment plan can be developed that reflects evidence of treatment efficacy, patient preference, and feasibility of implementation. Adjunctive therapies to lifestyle interventions, including more effective pharmacotherapeutics for obesity, offer hope to patients and the potential for considerable improvements in health and quality of life.
In the first evaluation and after the patient's consent, a standardized complementary questionnaire will be applied, with demographic and clinical information. The nutritionist will carry out the anthropometric assessment and questionnaires. Afterwards, they will be evaluated through the standard nutritional protocol of the nutrition clinic of the Institute of Cardiology and Children's Hospital Santo Antonio of Porto Alegre, whose standard nutritional prescription is a polymeric formula with a caloric density of 0.67 kcal/ml. Nutritional monitoring will take place through telephone contact for information on the baby's clinical data and in person before the surgery is performed.
OBJECTIVES: I. Determine whether oral eflornithine (DFMO) given in this study will cause significant reduction of the Ki67 labelling index in subjects with intestinal type Barrett's esophagus and low grade dysplastic Barrett's esophagus. II. Determine whether oral DFMO will alter the pathology and morphology of Barrett's esophagus. III. Determine whether there is a difference in cellular DNA ploidy and/or nuclear or nucleolar morphometry in patients with dysplastic Barrett's esophagus and nondysplastic intestinal type Barrett's esophagus compared to normal gastric fundic mucosa. Determine whether DFMO modulates changes in these surrogate endpoint biomarkers towards normal mucosal values. IV. Determine whether cells demonstrating nuclear p53 protein accumulation are either lost or undergo a change in cellular distribution, following treatment of patients with dysplastic Barrett's mucosa with DFMO. V. Determine whether DFMO modulates changes in growth factor or oncogene expression in dysplastic Barrett's esophagus and nondysplastic intestinal type Barrett's esophagus. VI. Determine whether pathologic or biologic surrogate modulation occurring during 6 months of DFMO treatment reverts 6 months after treatment is discontinued.

OUTLINE: This is a randomized, placebo controlled, double blind prevention study. Patients are initially stratified by dysplasia status at baseline (metaplastic vs low grade dysplastic) and treatment group (placebo vs eflornithine). Patients are randomized to receive daily doses of eflornithine (DFMO) or placebo for 26 weeks. At 0, 4, 8, 12, 16, 20, and 26 weeks there are toxicity and adherence evaluations and at weeks 26 and 52 patients have follow-up endoscopies.

PROJECTED ACCRUAL: A total of a 152 evaluable patients will be accrued in this study.
The Xen gel stent is a minimally invasive glaucoma surgical implant designed to decrease intraocular pressure (IOP) by creating an aqueous outflow path into the subconjunctival space. Since FDA approval, it has demonstrated good safety and efficacy data; however, there are multiple reports of Xen stent occlusions with debris from the anterior chamber. Herein, we report a case of a Descemet's membrane Xen stent occlusion in a 67-year-old woman with a past medical history of primary open angle glaucoma who underwent Xen stent placement through the ab externo approach. Her Descemet's membrane occlusion was successfully managed by Nd:YAG laser lysis. Although uncommon, small Descemet's tears or flaps can occlude the ostia of Xen stents causing elevated IOP or bleb failure. Few reports have described the use of Nd:YAG laser to successfully treat ostium occlusion of any kind with the Xen stent. We discuss the importance of early Nd:YAG laser to relieve Descemet's membrane occlusions, lower IOP, and rescue the bleb from failure.
Autoimmune cytopenias are defined by autoantibodies' immune destruction of one or more blood elements. Most often it is autoimmune hemolytic anemia or immune thrombocytopenia or both that define Evans syndrome. It may be secondary to infection or to underlying pathology such as systemic autoimmune disease or primary immunodeficiency, especially when it becomes chronic over several years. Primary Immunodeficiencies or inborn errors of immunity (IEI) are no longer defined solely by infections: autoimmunity is part of the clinical features of several of these diseases. It is dominated by autoimmune cytopenias, in particular, immune thrombocytopenia (ITP) and autoimmune hemolytic anaemia (AIHA). The challenges for the clinician are the situations where autoimmune cytopenias are chronic, recurrent and/or refractory to the various long-term therapeutic options. Most of these therapies are similar in action and generally consist of non-mediated immune suppression or modulation. In these situations, primary Immunodeficiencies must be diagnosed as soon as possible to allow the initiation of a targeted treatment and to avoid several ineffective therapeutic lines.
FIELD: medicine. ^ SUBSTANCE: invention belongs to medicine, notably to anaesthesiology and neurology, it can be used in conditions requiring a superior gluteal nerve block. To accomplish block patient lies on his stomach horizontally with feet adducted. First line is drawn at the back through projection of ischiadic bone's lower point on the frontal plane, and upper point of hipbone crest. Then second line is drawn through projection points of the most lateral protrusion of greater trochanter and lower margin of fourth lumbar vertebra's spinous process in men and second lumbar vertebra in women. Through intersection of both lines' projection point, perpendicularly to frontal plane hollow needle is inserted up to the bone, and then 2-5 ml of 1% trimecain solution is injected. Then needle is drawn 1 cm out and 50 ml of mixture containing 0.02 g of dexamethasone, diluted in 100 ml of 1% trimecain solution, is injected. Then needle is drawn out 1-1.5 cm more and 50 ml of mixture is injected. After that needle is drawn out until its point is situated in the middle of gluteus maximus muscle in which solution of vitamin B12 is injected at the basis of 4 mcg per kg of patient's body mass. ^ EFFECT: method allows raising superior gluteal nerve block's effectiveness due to enhanced accuracy of medication delivery. ^ 2 cl, 1 dwg, 2 ex
The invention discloses a preparation technology of a green hata Beta lymphocyte stimulator (BAFF) gene and a protein and relates to the technology of cloning, expression, protein purification and activity identification of the green hata BAFF gene. The overall length cDNA (complementary deoxyribonucleic acid) of green hata BAFF is obtained through RT-PCR (Reverse Transcription-Polymerase Chain Reaction) and RACE (Rapid-Amplification of cDNA Ends) technologies. The BAFF has the sequence shown in SEQ ID NO.1, and the protein encoded by a gene CDS open reading frame has the amino acid sequence shown in SEQ ID NO. 2. An extracellular functional zone can be fusibly linked to a pET28a pronucleus plasmid and be transferred to an escherichia coli BL21 (DE3) to be expressed, and an obtained protein is purified by an Ni<+>-NTA column to obtain a recombinant protein His6-EasBAFF. Experiments prove that the fusion protein is capable of obviously promoting survival of green hata lymphocytes and Beta lymphocytes of a mouse.
Recent advances in sensor technology for air pollution monitoring open new possibilities in the field of environmental epidemiology. The low spatial resolution of fixed outdoor measurement stations and modelling uncertainties currently limit the understanding of personal exposure. In this context, air quality sensor systems (AQSSs) offer significant potential to enhance personal exposure assessment. A pilot study was conducted to investigate the feasibility of the NO2 sensor model B43F and the particulate matter (PM) sensor model OPC-R1, both from Alphasense (UK), for use in epidemiological studies. Seven patients with chronic obstructive pulmonary disease (COPD) or asthma had built-for-purpose sensor systems placed inside and outside of their homes at fixed locations for one month. Participants documented their indoor activities, presence in the house, window status, and symptom severity and performed a peak expiratory flow test. The potential inhaled doses of PM2.5 and NO2 were calculated using different data sources such as outdoor data from air quality monitoring stations, indoor data from AQSSs, and generic inhalation rates (IR) or activity-specific IR. Moreover, the relation between indoor and outdoor air quality obtained with AQSSs, an indoor source apportionment study, and an evaluation of the suitability of the AQSS data for studying the relationship between air quality and health were investigated. The results highlight the value of the sensor data and the importance of monitoring indoor air quality and activity patterns to avoid exposure misclassification. The use of AQSSs at fixed locations shows promise for larger-scale and/or long-term epidemiological studies.
Epoetin Hospira will be administered by SC bolus injection 1 to 3 times per week per each patient's dosing schedule. Other ESAs (except for long-acting) may be used as rescue therapy.