anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An automated system and associated method for storing items comprises a cabinet having at least one refrigerated drawer using a temperature control device and a non-temperature controlled drawer. The drawer design is such that temperature gradients throughout the drawer are minimized. Faraday cages are provided about each drawer to support separate RFID readers to monitor the items in each drawer. The temperature-controlled drawer is insulated so that adjacent non-temperature controlled drawers are not significantly affected by the temperature of the temperature-controlled drawer and they may exist at room temperature. An automatic RFID data detection system determines the temperature requirements of medical items in the temperature-controlled drawer and controls the temperature control device to maintain the required temperature. A temperature logging system for the temperature controlled drawer is provided. A separate RFID reader determines if a temperature-controlled item has been placed in a non-temperature controlled drawer and if so, an alert is provided.
To detect redox potential evolution during the initial stage of an acute wound, a redox-sensitive SERS-active optical fiber was fabricated by integrating redox-sensitive SERS probes in a hole of an optical fiber. The redox-sensitive SERS-active optical fibers carried redox-sensitive SERS probes into the inside of a wound to sense its redox potential. The laser was transmitted to the redox-sensitive SERS probes in the body by optical fibers, and the SERS signals of the redox-sensitive SERS probes were transferred out of the body by optical fibers to indicate the redox potentials in the wound. The redox-sensitive SERS probes dynamically sensed the redox potential in vivo, and their SERS signals were collected constantly to indicate the redox potentials. The assessments in vivo and in vitro proved the responsiveness of redox-sensitive SERS-active optical fibers. The redox potential evolution during the initial stage of an acute wound with the treatments of different concentrations of glucose was detected to verify the feasibility of redox-sensitive SERS-active optical fibers to dynamically detect redox potentials in vivo. The redox-sensitive SERS-active optical fiber would be a versatile tool to explore the roles of redox potentials in living organisms.
Environmental exposure to a mixture of chemical xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis and the development of breast cancer (BC). Before anything else, we are what we eat. In this review, we highlight both "the good" and "the bad" sides of the daily human diet and dietary patterns that could influence BC risk (BCR) and incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, and raw food, increases apoptosis and autophagy, antioxidation, cell cycle arrest, anti-inflammation, and the immune response against BC cells. Moreover, a healthy diet could lead to a reduction in or the inhibition of genomic instability, BC cell stemness, growth, proliferation, invasion, migration, and distant metastasis. We also emphasize that, in addition to beneficial compounds, our food is more and more contaminated by chemicals with harmful effects, which interact with each other and with endogenous proteins and lipids, resulting in synergistic or antagonistic effects. Thus, a healthy and diverse diet, combined with appropriate nutritional behaviors, can exert anti-carcinogenic effects and improve treatment efficacy, BC patient outcomes, and the overall quality of life of BC patients.
Control group participants are the refugees who did not received the medication management review service and no pharmacist's counselling wsa provided to them during the study period. They have been assessed at baseline and at follow-up (after 3 months) home visits.
INTRODUCTION: To determine the frequency of superior cluneal nerve entrapment (SCN-E) in patients who applied to our outpatient clinic with low back pain.
METHODS: Two hundred patients with mechanical low back pain persisting more than 3 months were included in our study. All patients were evaluated with detailed clinical history and physical examination. Ultrasound-guided diagnostic injection was performed in patients who had tenderness on the posterior iliac crest and whose main complaint emerged by pressing on this point. Patients with 70% or greater pain relief 1 h after the injection were considered as SCN-E. The frequency and clinical features of SCN-E were determined and compared with other mechanical low back pain.
RESULTS: The mean age of the patients included in our study was 48.56 ± 14.11 years, with 138 female and 62 male patients. The diagnostic injection was performed on 31 patients and considered positive in 24 of them. The frequency of SCN-E was determined as 12%. The Hip-Knee Flexion Test was determined to be more specific for SCN-E than other causes of low back pain, the sensitivity and specificity of the test were 41.67% and 88.64% (p = 0.001; p < 0.01). In addition, all demographic and clinical features in patients diagnosed with SCN-E were found to be similar to other mechanical low back pain cases.
CONCLUSIONS: In patients with chronic low back pain, SCN-E is not a rare cause and is often overlooked. Increasing the awareness and experience of physicians on SCN-E will prevent patients from being exposed to unnecessary surgical or non-surgical treatments.
The invention discloses a Chinese medicine composite for treating enteritis and damp-heat diarrhea of poultry and aims at providing the Chinese medicine composite which can treat enteritis and damp-heat diarrhea of the poultry without drug fastness and drug residue in the body. The material composition which is prepared into active ingredients according to the parts by weight is as follows: 1 to 80 parts of root of Chinese pulsatilla, 1 to 80 parts of gentian and 1 to 80 parts of coptis root. In the Chinese medicine composition, the root of Chinese pulsatilla has the functions of clearing away heat and toxic material, removing heat from the blood and relieving diarrhea, the gentian can purge liver-gallbladder fire and remove downward flow of damp and heat, and the coptis root can clear away heat, eliminate dampness and purge fire to eliminate toxin. The combined use of the medicines can clear away heat and toxic material, removing heat from the blood and relieving diarrhea, which can treat enteritis and damp-heat diarrhea of the poultry. The medicine of the invention is pure Chinese herbal preparation and can address both the symptoms and root causes when treating enteritis and damp-heat diarrhea of the poultry, without drug fastness, thus ensuring the treatment effect. Besides, the medicine has no drug residue or toxic and side effect, thus ensuring human health.
The invention relates to a burn tincture, belonging to the field of traditional Chinese medicine science and a creative novel Chinese medicine preparation tincture for treating burn. The burn is an acute injury disease which is caused by heating power (such as flame, scorching gas, liquid or solid, electric energy, chemical substances, radioactive rays and the like), and is generally caused by flame and scorching liquid at ordinary times or wartime. The burn injuries the skin mostly, and also injuries muscles and bones, the serious injuries can endanger life because heat and toxins enter internal organs, and serious burn can cause lesions of all organs. In order to treat the burn, the problems of clearing away heat and toxins, relieving swelling and stopping pain, preventing bacterial infection, activating incompletely-dead histocyte to revive rapidly, promoting neogenesis of the histocyte as well as astringing dampness and arresting wounds need to be solved, and the solution scheme is a dosage prescription. The burn tincture comprises the following five medicaments, such as 1 part of snapweed tuber, 1 part of alum, 0.3 part of pollen pini and the like. The burn tincture is externally used and applied multiple times one day till healing.
FIELD: medicine. SUBSTANCE: method involves detecting signs of intrauterine infection or infectious fetopathy before carrying out surgical intervention for removing fertilized ovum from the uterine cavity. Samples are taken from the fetal material withdrawn from uterine cavity in the amount required for detecting infectious agents transferred in sexual way. The agents being detected, non-specific antibacterial therapy is substituted with specific one combined with non-specific immunostimulating therapy corresponding to the infectious agent detected. The treatment is carried out in regular way with patient state being under control until full recovery is achieved. EFFECT: enhanced effectiveness in preventing postoperative complications. 2 dwg
A composition suitable for use as a hairspray comprises a polyester having a melting point above 40 DEG  C. which is the esterification product of a phthalic acid or anhydride and at least one dihydric alcohol, and a propellant and/or a perfume. The preferred polyesters are the reaction products of a phthalic acid or anhydride, a dihydric alcohol and an at least trihydric alcohol.  The propellant may be a fluorocarbon, a chlorofluorocarbon and/or a hydrocarbon. The perfume used in the examples is a mixture of bergamot oil, linalyl acetate, geraniol, methyl ionone, essential lavender oil and ambretta musk. Optional ingredients exemplified are methylene dichloride, isopropanol, triethyl citrate, isopropyl myristate, lanoline, lanoline refinery product, paraffin oil, 2-acetyl-1,2,3-tributyl citrate and dimethylphthalate.ALSO:A composition suitable for use as a hairspray comprises a polyester having a melting point above 40 DEG C. which is the esterification product of a phthalic acid or anhydride and at least one dihydric alcohol, and a propellant and/or a perfume. The preferred polyesters are the reaction products of a phthalic acid or anhydride, a dihydric alcohol and a polyhydric alcohol. Propellants specified are chlorofluoromethanes, octafluorocyclobutane and mixtures of octafluorocyclobutane and isobutane, and monofluorotrichloromethane and difluorodichloromethane. The perfume exemplified is a mixture of bergamot oil, linalyl acetate, geraniol, methyl ionone, essential lavender oil and ambretta musk.  Optional ingredients exemplified are methylene dichloride, isopropanol, triethyl citrate, 2-acetyl-1,2,3-tributyl citrate, isopropyl myristate, dimethyl phthalate, lanolin, lanolin refinery product and paraffin oil.ALSO:A composition suitable for use as a hairspring comprises a polyester having a melting-point above 40 DEG  C. which is the esterification product of a phthalic acid or anhydride and at least one dihydric alcohol, and a propellant and/or a perfume. The polyester may be the esterification product of a mixture of a dihydric and a polyhydric alcohol.  The perfume used in the examples is a mixture of bergamot oil, linolyl acetate, geraniol, methyl ionone, essential lavender oil and ambretta musk.  Optional ingredients exemplified are methylene dichloride, isopropanol, triethyl citrate, 2-acetyl-1,2,3-tributyl citrate, dimethyl phthalate, isopropyl myristate, lanolin, lanolin refinery product and paraffin oil.
PCT No. PCT/GB92/01511 Sec. 371 Date Jun. 22, 1994 Sec. 102(e) Date Jun. 22, 1994 PCT Filed Aug. 14, 1992 PCT Pub. No. WO93/03710 PCT Pub. Date Mar. 4, 1993.Contaminating protein is removed from a water soluble gum such as alginate by dialyzing a solution of the gum against a solution of a disulphide bond reducing agent. Purifying the gum by removing antigenic protein improves biocompatability of the gum for making biocompatible capsules containing cells such as mammalian cells. The reducing agent is preferably dithiothreitol, dithioerythritol or 2-mercaptoethanol. Dialyzing is preferably carried out for more than 1 hour and more preferably twice, each time for 2 hours. Cells are encapsulated by forming a suspension of cells in an aqueous solution of the gum, forming droplets from the suspension, gelling the droplets with a multivalent cation, contacting the gelled droplets with a polymer containing cationic groups, such as poly-1-lysine chloride, that cross-link with anionic groups of the gum to form a semi-permeable membrane around the droplets, and coating the membrane with a layer of the dialyzed gum. Islets of Langerhans cells can be encapsulated for implanting to produce insulin. In addition to encapsulating cells, the purified gum can be used in making dressings, swabs, sutures, stitches, controlled or sustained release devices and artificial vascular grafts that come in contact with body fluids such as blood.
In this study, we focus on the impacts of spatial-temporal heterogeneity of human-to-human contacts on the spread of infectious diseases and develop a multi-type branching process model by introducing random human-to-human contact mode into a structured population. We provide the general formulas of the generation size, extinction probability, and basic reproduction number of the proposed branching process model. The result shows that the natural temporal heterogeneity (i.e. random contacts over time) can lead to a higher extinction probability while remains the same basic reproduction number and generation size. This is also numerically verified by choosing the real contact distributions from different circumstances of four countries. In addition, we observe a non-monotonic pattern of the differences, against the transmission probability and the mean contact rate, between the extinction probabilities under the constant and random contact patterns. Given the spatial heterogeneity, we show that it can contribute to the increase of basic reproduction number, but also increase the extinction probability of the infectious disease. This study adds novel insights to the course of the impact of heterogeneity on the transmission dynamics and also provides additional evidence for the limited role of reproduction numbers.
OBJECTIVE: Understanding preferences of patients with rheumatoid arthritis (RA) can facilitate tailored patient-centric care. This study elicited trade-offs that patients with RA were willing to make during treatment selection.
METHODS: Patients with RA completed an online discrete choice experiment, consisting of a series of choices between hypothetical treatments. Treatment attributes were selected based on literature review and qualitative patient interviews. Eligible patients were ≥18 years old, diagnosed with RA, receiving systemic disease-modifying antirheumatic drug therapy, and residents of Europe or USA. Male patients were oversampled for subgroup analyses. Data were analysed using a correlated mixed logit model.
RESULTS: Of 2090 participants, 42% were female; mean age was 45.2 years (range 18-83). Estimated effects were significant for all attributes (p<0.001) but varied between patients. Average relative attribute importance scores revealed different priorities (p<0.001) between males and females. While reducing pain and negative effect on semen parameters was most important to males, females were most concerned by risk of blood clots and serious infections. No single attribute explained treatment preferences by more than 30%. Preferences were also affected by patients' age: patients aged 18-44 years placed less importance on frequency and mode of treatment administration (p<0.05) than older age groups. Patients were willing to accept higher risk of serious infections and blood clots in exchange for improvements in pain, daily activities or administration convenience. However, acceptable trade-offs varied between patients (p<0.05).
CONCLUSION: Treatment preferences of patients with RA were individual-specific, but driven by benefits and risks, with no single attribute dominating the decision-making.
PURPOSE:A remedy and preventive for ulcer of digestive organs having extremely low toxicity, and improved medicinal effect such as inhibitory activity against secretion of acid in the stomach, inhibitory activity against total pepsins, etc., containing an alkylated Fab fragment of human IgG as an active ingredient. CONSTITUTION:An alkylated Fab fragment of human IgG is as an active ingredient of a remedy and preventive for ulcer of digestive organs. The alkylated Fab fragment is obtained by scissoring disulfide bond of Fab fragment of human IgG, alkylating it. It is found that the alkylated Fag fragment has low toxicity, improved antiulcer action, and extremely effective as a remedy and preventive for ulcer. The medicinal action of it has inhibitory activity against secretion of acid in the stomach, inhibitory activity against total acidity and total pepsins. It is used as powder, tablet, capsule, liposome pharmaceutical preparation, etc. for oral medication, or venoclysis, or intramuscular injection. A dose is preferably 1-100mg/kg/day.
The invention discloses a naringin solid dispersion, and the preparation method and the application thereof. The naringin solid dispersion contains naringin and vector material. The mass ratio of naringin and the vector material is 1:2 to 1:5. The vector material is any one of or any mixture of polyethylene glycol, polyvinyl pyrrolidone and poloxamer. The preparation method of the naringin solid dispersion is to get the naringin, the vector material and the other regular auxiliary materials by melting method, solvent method, solvent-melting method, spray drying method or freeze-drying method. The application of the naringin solid dispersion is to apply in preparing pharmaceutical preparations or healthfood. The invention of the naringin solid dispersion is to disperse naringin by solid dispersion technique, which improves the solubility in water and dissolution rate in vitro and at the same time enhances the bioavailability.
An antimicrobial wipe is disclosed comprising a substrate and an antimicrobial composition. The antimicrobial composition contains a sulfonated block copolymer having an ion exchange capacity (IEC) of >0.5 meq/g, and (ii) a solvent system. The solvent system contains a mixture of two or more solvents selected from the group consisting of organic solvents, inorganic solvents, terpene-based compounds, and decarboxylated rosin acids. The antimicrobial wipe is in the form of a fabric, a sponge, a toilette, and the like. The sulfonated block copolymer is partially or fully dissolved in the solvent system, such that when the wipe is in contact with a target surface, the sulfonated block copolymer is imparted from the wipe onto the surface forming a coating layer. The coating layer causes a reduction in a microbe concentration by at least 1 log10 CFU (colony forming units) within 120 minutes upon contact.
Biological human-computer interfaces are used to control devices, such a robotic limbs, using brain signals, nerve signals and muscle signals. These interfaces are sometimes called brain-computing interfaces. The learning process for a user to control devices using these interfaces is cumbersome. A computing platform is provided that includes a library of human model templates that are used to take biological inputs signals to generate outputs that control the device. Different templates are more appropriate for users of different attributes, such as demographic attributes. The computing platform collects data from multiple other users with these interfaces and devices in order to calibrate the human model templates. The calibrated human model templates are then published to the individual users, so that they can more accurately control their devices using their biological input signals.
BACKGROUND: Pain management and early mobilization strategies are recommended in clinical practice guidelines for the prevention of delirium in older adults. However, available data on the implementation of these strategies in trauma are limited.
AIMS: To describe the use of pain management and early mobilization strategies in older adults at a level I trauma center, as well as the facilitators and barriers to their implementation.
METHODS: A convergent mixed methods study was used. Quantitative data were collected from sixty medical records. Qualitative data was collected through a focus group with healthcare providers to explore their perspectives regarding the use of the target practices and on barriers and facilitators to their implementation. Descriptive statistics were calculated, and a thematic analysis using an inductive and deductive interpretative descriptive approach was undertaken.
RESULTS: A question on the presence/absence of pain was the most frequently documented pain assessment method. Pain assessment was poorly documented. Frequencies of non-opioid and opioid administrations were similar, but non-pharmacological strategies were not widely used. The first mobilization was performed quickly and was most commonly to a chair. The focus group discussion confirmed many of the data collected in the medical records. Barriers to implementing the targeted strategies were primarily related to organizational context and facilitation processes.
CONCLUSIONS: Areas for improvement were identified including pain assessment, the use of non-pharmacological pain management strategies and ambulation as a mobilization strategy. Our findings will serve as a starting point for optimizing and adapting practices for geriatric trauma patients and evaluating their impact.
The Regulator of Telomere Helicase 1 (RTEL1) gene encodes a critical DNA helicase intricately involved in the maintenance of telomeric structures and the preservation of genomic stability. Germline mutations in the RTEL1 gene have been clinically associated with Hoyeraal-Hreidarsson syndrome, a more severe version of Dyskeratosis Congenita. Although various research has sought to link RTEL1 mutations to specific disorders, no comprehensive investigation has yet been conducted on missense mutations. In this study, we attempted to investigate the functionally and structurally deleterious coding and non-coding SNPs of the RTEL1 gene using an in silico approach. Initially, out of 1392 nsSNPs, 43 nsSNPs were filtered out through ten web-based bioinformatics tools. With subsequent analysis using nine in silico tools, these 43 nsSNPs were further shortened to 11 most deleterious nsSNPs. Furthermore, analyses of mutated protein structures, evolutionary conservancy, surface accessibility, domains & PTM sites, cancer susceptibility, and interatomic interaction revealed the detrimental effect of these 11 nsSNPs on RTEL1 protein. An in-depth investigation through molecular docking with the DNA binding sequence demonstrated a striking change in the interaction pattern for F15L, M25V, and G706R mutant proteins, suggesting the more severe consequences of these mutations on protein structure and functionality. Among the non-coding variants, two had the highest likelihood of being regulatory variants, whereas one variant was predicted to affect the target region of a miRNA. Thus, this study lays the groundwork for extensive analysis of RTEL1 gene variants in the future, along with the advancement of precision medicine and other treatment modalities.