anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sepsis is a systemic illness for which there are no effective preventive or therapeutic therapies. Zerumbone, a natural molecule, has anti-oxidative and anti-inflammatory properties that may help to prevent sepsis. In the present study, we have assessed the protective effect of zerumbone against sepsis-induced acute lung injury (ALI) and its underlying mechanisms. During the experiment, mice were divided into five groups: a sham group, a sepsis-induced ALI group, and three sepsis groups that are pre-treated with zerumbone at different concentrations. We found that zerumbone greatly decreased the sepsis-induced ALI using histological investigations. Also, zerumbone treatment reduced the sepsis-induced inflammatory cytokine concentrations as well as the number of infiltrating inflammatory cells in BALF compared to non-treated sepsis animals. The zerumbone-pretreated sepsis groups had reduced pulmonary myeloperoxidase (MPO) activity than the sepsis groups. Moreover, the mechanism underlying the protective action of zerumbone on sepsis is accomplished by the activation of antioxidant genes such as nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), superoxide dismutase (SOD), and heme oxygenase 1 (HO-1). The obtained results revealed that zerumbone inhibited the sepsis-induced ALI through its anti-inflammatory and antioxidative activity via inhibition of the NF-κB pathway and activation of HO-1 pathway. Our findings demonstrate that zerumbone pretreatment suppresses sepsis-induced ALI via antioxidative activities and anti-inflammatory, implying that zerumbone could be a viable preventive agent for sepsis-induced ALI.
The patients have seated the knee joints in full extension and both ankle joints in a neutral position. Neuromuscular electrical stimulation (NMES) was applied to the non-affected side ankle dorsiflexors for five days, five sessions for a week. In addition to this application, a cold pack was applied on the affected side dorsiflexor muscle skin. The cold pack was applied on a moist towel for five minutes. A five-minute break was given and a further 5-minute cold application was repeated. The cold application was done simultaneously with NMES.
In initiating treatment for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of GLUCOTROL XL or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short-term administration of GLUCOTROL XL or other antidiabetic medications. Maintenance or discontinuation of GLUCOTROL XL or other antidiabetic medications should be based on clinical judgment using regular clinical and laboratory evaluations.
This is an intra-person study, comparing outcomes within participants. All participants will receive active 1470 nm intra-lesional diode laser treatment on one HS tunnel. Half of the enroled patients will receive active treatment of the right side, while the HS tunnel on the left side will be left as an untreated control.
A skin care evaluation method, which is adapted for an electronic device to evaluate a skin care procedure including a plurality of skin care behaviors. The skin care evaluation method includes following steps. A plurality of image information is sequentially captured at a plurality of image capturing time. A plurality of user actions corresponding to the image information is analyzed, where a plurality of consecutive image information of the image information corresponds to one of the user actions. The image information is classified to the skin care behaviors according to the user action corresponding to each of the image information. Each of the skin care behaviors corresponds to a plurality of the user actions. A duration of each of the skin care behaviors is calculated according to the image capturing time of the image information classified to each of the skin care behaviors. An electronic device using the skin care evaluation method is also provided.
BACKGROUND: Recent studies have suggested that the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) level serve as a significant risk factor for mortality in patients with end-stage renal disease. However, the relationship between NT-proBNP levels and technique failure in peritoneal dialysis-associated peritonitis (PDAP) remains unclear. This study investigated the relationship between NT-proBNP levels at the onset of PDAP and the risk of technique failure in patients with PDAP.
METHODS: A retrospective analysis was conducted on patients with PDAP from December 1, 2009, to December 31, 2021, at our peritoneal dialysis center. We recorded all demographic and baseline clinical data at the time of admission for each PDAP episode. Logistic and Cox regression analyses were performed to assess the association between NT-proBNP levels and technique failure.
RESULTS: Of 485 PDAP episodes included in this study, 130 episodes of technique failure were observed. Multivariate logistic analysis revealed that hospital stay, Na and NT-proBNP levels, and peritoneal dialysate white blood cell counts on days 3 and 5 were independently associated with technique failure. The receiver operating characteristic curve demonstrated that the NT-proBNP level was a better indicator than the other four variables in indicating technique failure. In the multivariate Cox regression analysis, after adjusting for confounding factors, higher NT-proBNP levels (HR of 3.020, 95% CI 1.771, 5.150, P < 0.001) were associated with PDAP technique failure.
CONCLUSIONS: This retrospective study identified the serum NT-proBNP level at the onset of PDAP as an independent risk factor for technique failure in these patients.
PURPOSE: To provide an antioxidant and an active oxygen scavenger containing extract of mulberry fruit or mulberry leaf as an active component and useful in the field of foods, food additives, cosmetics, pharmaceuticals, etc. CONSTITUTION: Mulberry fruit or mulberry leaf is extracted with water or a hydrophilic organic solvent (e.g. ethanol). For example, dried mulberry fruit is extracted with water by washing dried mulberry fruit with water, cutting into small pieces, adding boiling water to the cut pieces and extracting with hot water for 5min. The extract is passed through a wire gauze to remove foreign materials, concentrated at 50 deg.C under reduced pressure and freeze-dried to obtain a dried extract. The objective natural antioxidant and active oxygen scavenger effective for preventing the oxidation-induced quality-deterioration and eliminating active oxygen can be produced by using the extract as an active component. The extract is derived from natural resource and nevertheless it exhibits antioxidation activity stronger than α-tocopherol and comparable to chemically synthesized products.  The natural active oxygen scavenger exhibits active oxygen scavenging action comparable to chemically synthesized product and is easily available at a low cost.
OBJECTIVE: Our goal was to study the tolerance and efficacy of two B cell depletion strategies, including one with CD19-targeted chimeric antigen receptor (CAR) T cells, in a preclinical model mimicking the severe lung damages observed in systemic sclerosis.
METHODS: B cell depletion strategies were evaluated in the Fra-2 transgenic (Tg) mouse model. We considered a first group of 16 untreated mice, a second group of 15 mice receiving a single dose of anti-CD20 monoclonal antibody (mAb), and a third group of 8 mice receiving CD19-targeted CAR-T cells in combination with anti-CD20 monoclonal antibody. After six weeks of clinical evaluation, different validated markers of inflammation, lung fibrosis, and pulmonary vascular remodeling were assessed.
RESULTS: CD19-targeted CAR-T cells infusion in combination with anti-CD20 mAb resulted in a deeper B cell depletion than anti-CD20 mAb alone in the peripheral blood and lesional lungs of Fra-2 Tg mice. CAR-T cell infusion worsened the clinical score and increased mortality in Fra-2 Tg mice. In line with the above findings, CAR-T cell infusion significantly increased lung collagen content, the histological fibrosis score, and right ventricular systolic pressure. CAR-T cells accumulated in lesional lungs and promoted T activation and inflammatory cytokine production. Treatment with anti-CD20 mAb in monotherapy had no impact on lung inflammation-driven fibrosis and pulmonary hypertension.
CONCLUSION: B cell therapies failed to show efficacy in the Fra2 Tg mice. The exacerbated Fra-2 lung inflammatory burden stimulated accumulation and expansion of activated CD19-targeted CAR-T cells, secondarily inducing T cell activation and systemic inflammation, finally leading to disease worsening.
Dimensional models of psychopathology may provide insight into mechanisms underlying comorbid depression and anxiety and improve specificity and sensitivity of neuroanatomical findings. The present study is the first to examine neural structure alterations using the empirically derived Tri-level Model. Depression and anxiety symptoms of 269 young adults were assessed using the Tri-level Model dimensions: General Distress (transdiagnostic depression and anxiety symptoms), Anhedonia-Apprehension (relatively specific depression symptoms), and Fears (specific anxiety symptoms). Using structural MRI, gray matter volumes were extracted for emotion generation (amygdala, nucleus accumbens) and regulation (orbitofrontal, ventrolateral, and dorsolateral prefrontal cortex) regions, often implicated in depression and anxiety. Each Tri-level symptom was regressed onto each region of interest, separately, adjusting for relevant covariates. General Distress was significantly associated with smaller gray matter volumes in bilateral orbitofrontal cortex and ventrolateral prefrontal cortex, independent of Anhedonia-Apprehension and Fears symptom dimensions. These results suggests that prefrontal alterations are associated with transdiagnostic dysphoric mood common across depression and anxiety, rather than unique symptoms of these disorders. Additionally, no regions of interest were associated with Anhedonia-Apprehension or Fears, highlighting the importance of studying transdiagnostic features of depression and anxiety. This has implications for understanding mechanisms of and interventions for depression and anxiety.
This project will determine if a data-assisted, high intensity medical weight loss intervention (HIWL) will lead to significant weight loss and diabetes remission in individuals with a Body Mass Index (BMI) 30-39.9 kg/m2 with T2DM of less than 6 years as compared to a diabetes self-management education intervention (DSME). Complete diabetes remission is considered to be achieved when the patient is not taking any anti-diabetes medication for at least 12 months, and the Glycated Hemoglobin (HbA1c) is \< 5.7%. Partial remission is achieved when the patient is not taking any anti-diabetes medication and has an HbA1c of 5.7-6.4% for at least 12 months.Using a randomized controlled study design, we will randomly assign 90 participants to HIWL, HIWL + continuous glucose monitoring (CGM), or DSME. Participants assigned to HIWL will receive a high intensity behavioral weight loss intervention delivered using a digital patient engagement platform. Participants will be prescribed a low calorie dietary plan and a recommended physical activity program designed to produce 15-20% weight loss over 12 months. Those assigned to HIWL + CGM will receive the same intervention as HIWL; in addition we will provide them with CGM to use as part of their remote monitoring on a daily basis. Those assigned to DSME will participate in a comprehensive diabetes education program designed to provide education and skills for optimal diabetes management plus lifestyle modification counseling to produce 5% weight loss over the same timeframe. The primary outcome of weight loss will be assessed at 12 months.
Fluid management is optimised using the specific echographic hemodynamic algorithm ('STOPFLUID') of this study described during the first 4 days of septic shock. Fluid bolus will not be administered in case of increased left ventricle filling pressures; fluid challenge will be performed based on dynamic indices and fluid depletion will be considered on the basis of Lung UltraSound (LUS) assessment.
OBJECTIVES: Platelet concentrates are biomaterials with significant potential in tissue regeneration, functioning as scaffolds with greater leukocyte inclusion and a flexible fibrin mesh. However these concentrates have different preparation methods and biological properties. The objective of this clinical investigation was to evaluate the effects of utilizing platelet-rich fibrin (PRF) materials (L-PRF and A-PRF) as a palatal bandage following free gingival graft (FGG) on patients' morbidity and oral health-related quality of life.
MATERIALS AND METHODS: Thirty-nine participants received FGG to promote keratinized tissue and treat gingival recession. Participants were randomly assigned to L-PRF, A-PRF, and control groups, with 13 participants in each. They used a visual analog scale (VAS) to rate their pain, analgesic medication use, dietary changes, discomfort, and bleeding at 1-7 days, 14 days and 1 month during the healing process. Patients' quality of life was assessed using the Oral Health Impact Profile (OHIP-14) at baseline, 1-7 days, 14 days, 1 month, and 6 months.
RESULTS: There was no difference in anxiety levels between the all groups. (p > 0.05). The control group had higher OHIP-14 total scores than the other groups, but the differences were not statistically significant, especially in the first seven days (p > 0.05). In addition, the PRF groups showed an improvement in quality of life after 14 days, 1 month, and 6 months (p < 0.05). Patients' pain and suffering decreased with healing. The control group took more postoperative analgesics than PRF groups. In addition, there was a significant decrease in patient complaints about medicine intake, bleeding, pain, perceived sensitivity, and dietary modifications in all groups during follow-up.
CONCLUSIONS: PRF palatal bandages may improve patient's quality of life, donor site healing, postoperative pain and morbidity.
CLINICAL RELEVANCE: This study found that preserving the palate in FGG and employing PRF materials that speed palate healing reduce discomfort and morbidity.
The seasonal vaccine (Agriflu, Novartis) contains egg-derived, inactivated and detergent split versions of the 3 influenza strains (tri-valent). It is given into the muscle of the upper arm at a dose of 0.5 mL.
A system for assisting the exchange of information between healthcare providers, third party payors and persons receiving healthcare, employs an electronic data index with a record for each person identified listing the payors and/or providers with data regarding that person and instructions for accessing these data. The index records are established and may be accessed through a hash function based on covered persons' names and further identification such as birthdates. Authorized Requestors seeking information with regard to a covered person enter the person's name and further identifying information into a hash value generator in order to create the identifying hash function. A hash table identifies the location of the index record related to that individual in the data index. The index record identifies payors and providers with data on the person associated with the index record. The index record also contains instructions for accessing these files from the payors and providers. This process enables the retrieval of all data on the person in a convenient, anonymous and error-free manner.
The invention provides beverage for expelling dampness and cold, regulating qi and blood, nourishing intestines and stomach, relieving cough and asthma, eliminating phlegm, preventing miscarriage and enhancing human body resistance, and a preparation method thereof. A care product comprises 1,000 parts of Chinese mugwort shoot tip in Hubei, and 50 parts of liquorice. The beverage can be used for recuperating aiming at the symptoms such as female menstrual irritability, urine burning, dry and bitter mouth, loving of cold water, constipation and difficult defecation, red tongue with yellowish fur, rapid and weak pulse and the like. The beverage also can play a miscarriage prevention role aiming at a pregnant woman. The beverage also can be used for recuperating aiming at the symptoms such as dysmenorrheal in a menstrual period of a woman, lower abdomen cold and pain, menorrhagia or overlong menstrual period and the like. The beverage also can play the roles in resisting bacteria and viruses, relieving cough and asthma, eliminating phlegm, calming down, resisting allergy, protecting the liver and promoting guts, expelling cold and dampness and the like aiming at all people over the age of 15.
Methods are provided for diagnosing and/or characterizing disease involving abnormal levels of cellular apoptosis activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a disease involving abnormal levels of cellular apoptosis. The sample is then assayed for the presence of low molecular weight Actin protein fragments. The assay results are used to diagnose the presence of disease involving abnormal levels of cellular apoptosis activity and/or characterize disease involving abnormal levels of cellular apoptosis activity in the subject, e.g. to confirm an initial disease involving abnormal levels of cellular apoptosis diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.
* Reconstitute Glucagon for Injection with 1 mL of Sterile Water for Injection. Using a syringe, withdraw all of the Sterile Water for Injection (if supplied) or 1 mL Sterile Water for Injection and inject into the Glucagon for Injection vial. 
  * Shake the vial gently until the powder is completely dissolved and no particles remain in the fluid. The reconstituted fluid should be clear and colorless. Inspect visually for particulate matter and discoloration. If the resulting solution is cloudy or contains particulate matter do not use. 
  * The reconstituted solution is 1 mg per mL glucagon. 
  * Immediately after reconstitution, inject the solution intravenously or intramuscularly into upper arm, thigh, or buttocks. 
  * Discard any unused portion. 
  * After the end of the diagnostic procedure, give oral carbohydrates to patients who have been fasting, if this is compatible with the diagnostic procedure.
In an attempt to accelerate recovery many orthopedic surgeons have opted to utilize a direct anterior approach (DAA) as opposed to the more traditional posterolateral approach (PLA) in regards to total hip arthroplasty (THA). The DAA technique involves dissection of muscular planes for insertion of components resulting in less tissue damage as compared to PLA. Traditionally the study team has performed Lumbar Plexus blocks (LPB) to provide post-operative analgesia for total hip arthroplasty. This technique works well for the traditionally performed PLA in that the hip joint and incision site are within the analgesic distribution of the LPB. Conversely, the DAA utilizes an anterior incision that overlies the L1 and L2 dermatomes as opposed to the lower lumbar dermatomes of the PLA incision. When performing LPB it has been the study team's clinical experience that it is rare to achieve analgesia in the proximal distribution of the lumbar plexus resulting in apparent sparing of the L1 and L2 nerve root distributions. The quadratus lumborum block (QLB) is a newer regional analgesic technique that may be as effective as LPB at providing pain control following DAA hip arthroplasty. The QLB is thought to provide analgesia by blocking both the lateral and anterior cutaneous branches of T7 through L4. This degree of dermatomal coverage suggests that QLB could be an efficacious alternative to LPB for DAA hip arthroplasty. It is hypothesized that the QLB will provide equivalent analgesia when compared to the LPB as determined by a comparison of verbal reported pain scores.
BACKGROUND: Adolescent risky sexual behaviors in Nigeria pose significant public health challenges, including unplanned pregnancies, unsafe abortions, and sexually transmitted infections (STIs). Understanding the determinants of these behaviors in urban and rural contexts is crucial for effective intervention development.
OBJECTIVE: This study explored the determinants of risky sexual behaviors and access to adolescent reproductive health services (ARHS) among in-school adolescents in Enugu State, Nigeria.
METHODS: A descriptive cross-sectional design with mixed methods was utilized, involving 880 adolescents aged 10-19 years from eight schools (four urban, four rural) for quantitative analysis and 80 adolescents for qualitative analysis. Data were gathered through self-administered questionnaires and focus group discussions (FGDs). Statistical analyses included descriptive statistics, chi-square tests, and logistic regression with a significance level of p<0.05.
RESULTS: Among respondents, 420 (47.7%) reported being sexually active, with similar figures in urban (212; 48.2%) and rural (208; 47.3%) areas. The mean age for the sexual debut was identical across groups: 14.62 years (SD 1.768). The majority (85.5%) had multiple sexual partners. Condom use was low in both groups: 18.9% in urban and 9.6% in rural areas. Almost half of both groups (46.2% urban, 49.0% rural) never used condoms. Substance use was strongly associated with risky sexual practices, particularly alcohol, followed by marijuana and cigarettes. Notably, 86% of adolescents who used substances before sex did not use condoms, and 47% reported forced sex. Key determinants of risky behavior included poverty, peer pressure, and poor parental supervision. Access to ARHS was limited, with concerns about stigma and confidentiality; 57.7% lacked access, with rural adolescents facing poorer access (66.3%) than their urban counterparts (47.5%).
CONCLUSION: The study underscores the need for increased awareness, parental involvement, and targeted interventions to improve ARHS access and reduce risky sexual behaviors among adolescents in Enugu State.