anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the dynamic landscape of Breast Cancer (BC), Oligo- Metastatic Breast Cancer (OMBC) presents unique challenges and opportunities. This comprehensive review delves into current strategies for addressing OMBC, covering locoregional and site-specific metastasis management, and addressing both surgical and minimally invasive therapies as essential components. Moreover, the transformative role of Artificial Intelligence (AI) is spotlighted. However, while the future looks promising, several limitations need addressing, including the need for further research, especially in diverse patient populations and resource-challenged settings. AI implementation may require overcoming the lack of Electronic Health Records acceptance in resource-challenged countries, which contributes to a scarcity of large datasets for AI training. As AI continues to evolve, validation and regulatory aspects must be continually addressed for seamless integration into clinical practice. In summary, this review outlines the evolving landscape of OMBC management, emphasizing the need for comprehensive research, global collaboration, and innovative AI solutions to enhance patient care and outcomes.
Participants allocated to the experimental group will receive a short term postoperative puncture site compression via TR Band. In experimental group, TR Band deflation is commenced at the 1st hour with 3 mL air released, and at the 2nd hour with 5ml, and at the 3rd hour with the remainder air in the bladder, and the TR Band is removed at the 12th hour.
The invention discloses a traditional Chinese medicine composition for preventing and treating lung cancer based on prescription optimization and application thereof in pharmacy. Belongs to the field of traditional Chinese medicine. The invention provides a Chinese medicinal composition for treating non-small cell lung cancer; the composition comprises radix astragali, rhizoma Polygonati, radix Ophiopogonis, and herba Epimedii. The composition has good effects of preventing and treating the non-small cell lung cancer, is used for preparing a preparation for treating the non-small cell lung cancer by using corresponding pharmaceutical dosage forms in the field of preparations, and can be applied to various dosage forms in the field of pharmaceutical preparations. The invention combines the modern traditional Chinese medicine development theory, and obtains the traditional Chinese medicine compound with the best curative effect by screening the compatibility of the traditional Chinese medicine compound from the aspects of improving the curative effect of the medicine, reducing the toxic and side effect, improving the life quality of the lung cancer patients and prolonging the life cycle of the patients, and has good curative effect on the non-small cell lung cancer. Compared with the prior art, the traditional Chinese medicine composition has the remarkable treatment advantages of treating both principal and secondary aspect of disease, preventing relapse, having no toxic or side effect and the like.
The present invention relates to a feed composition for a layer chicken, containing an anticancer ingredient. According to one aspect of the present invention, the feed composition for a layer chicken, containing the anticancer ingredient comprises: a first main material group containing the anticancer ingredient comprising (A) gulfweed and (B) Gleditsia sinensis lamarck; a second main material group containing nutrient ingredients of an oriental medicine comprising (C) kelp; and a sub material group selectively containing one among drinking water, germanium water, and mica water in 75-90 wt% based on a total weight of a composition and containing 10-25 wt% of (D) the first and second main material groups. The ingredient of the first and second main material groups comprises: 70-80 wt% of the gulfweed; 15-22 wt% of Gleditsia sinensis lamarck; and 5-8 wt% of the kelp. According to the present invention, the feed composition for a layer chicken contains a functional extract of a plant and the oriental material of the gulfweed, the Gleditsia sinensis lamarck, and the kelp as active ingredients. So, the feed composition for a layer chicken is supplied to a layer chicken to raise the layer chicken. So, the feed composition for a layer chicken enables production of eggs properly containing the active ingredients of the oriental material and the anticancer ingredient. Also, the feed composition for a layer chicken can minimize the usage of antibiotic and can largely reinforce an immunity level of the layer chicken. The feed composition for a layer chicken is also environmentally friendly and is suitable for well-being. Also, the feed composition for a layer chicken meets consumers′ demands for food quality and increases the income of poultry farming.
The main objective of this trial is to evaluate the efficacy of the antibiotic after tooth extraction in preventing infections and to evaluate the effect of probiotic in reducing the possible antibiotic side effects. In order to analyze the effect of the antibiotic in terms of patient's general discomfort, a tailored form was prepared (Appendix A). The local signs and symptoms to evaluate are swelling, pain (assessed by the Visual Analogic Scale), presence of abscess, fever, post-extraction dental alveolitis (dry socket) and presence of trismus assessed as maximal mouth opening variation (mm). In addition adverse post-extraction events will be evaluated as follows: chewing impairments (assessed by the Visual Analogic Scale), speaking impairments (assessed by the Visual Analogic Scale), daily oral hygiene maneuvers impairments (assessed by the Visual Analogic Scale) and daily activities alterations (days-off from job/study). Moreover, the patients will be provided with a painkiller's prescription and they are required to take note of the painkillers needed during the first 7 days, i.e. until the first time point recall. The prescribed painkillers will be Ibuprofen 600 mg or naproxen sodium 500mg for those patients who reported allergy to ibuprofen. Finally, it will be a researcher duty to ask the patients if they needed to assume painkillers beyond the 7th day. Since the post-surgical sequelae depend also on the difficulty of extraction, the Appendix A provides a table in which the surgeon can take note of the type of extraction.
Experiment 2 tests whether participants actually drive more aggressively after a playing a violent or nonviolent racing video game. After giving their consent, participants (N=60, n=30 each group) will complete the same personal variables as in Experiment 1, and will report the video games they play. Next, participants will be randomly assigned to play one of two types of video games for 20 minutes: (1) violent racing video game, (2) nonviolent racing game, or (3) a neutral game. After participants complete the driving scenario, participants will complete measures of state and hostile appraisals. A debriefing will follow.
Parkinson's disease is a progressive disorder of the central nervous system which affects movement. Some signs and symptoms of PD include; tremors, rigidity, gait impairments, and balance disruption. Individuals with PD experience substantially impaired balance ultimately affecting their functional abilities. With this, individuals with PD may also experience lower quality of life due to these diminished determinants. Currently, there are medications which have proven to mask the symptoms of Parkinson's such as levodopa. There are also exercise programs which have proven to improve the symptoms of Parkinson's disease such as resistance based exercises and Tai Chi.based on the proven benefits of balance and overall quality of life through Shotokan-karate training, the purpose of this study will be to compare Shotokan-karate training versus Tai Chi on balance and quality of life in individuals with Parkinson's disease. Based on the literature available on the benefits of shotokan-karate on balance and quality of life in the elderly, it is hypothesized that shotokan-karate will improve balance and quality of life due to its high intensity, increased engagement and similarities to everyday movements. If the following hypothesis is supported, the present study will allow for individuals with Parkinson's disease to engage in an exercise program that shows vast improvements in their postural stability and overall quality of life. In addition, participants will be able to engage in an exercise program which will provide them with long term benefits and they will be able to implement this in their everyday lifestyle.
Monalizumab treatment will be initiated 75 to 100 days after hematopoietic stem cells transplantation. Patients will receive a single dose of monalizumab by intravenous route over 1 hour.
The purpose of the pilot study is to observe preliminary trends in neural response to subconcussive head impacts in hypoxic condition. This work will provide a critical un-tested knowledge regarding the combined effects of subconcussion and hypoxic condition (mimicking high altitude), which will be used in our upcoming grant proposal to the Department of Defense (DoD). Military personnel, particularly those who are deployed to Afghanistan, are constantly subjected to hypoxic condition, given that the majority of military land operations in Afghanistan occur at 2000-3000 meters (6500-10,000 feet). This level of altitude does not elicit major side effects, yet neural functions may experience some degree of perturbation (i.e., slowed reaction time, altered night vision). Concurrently, these military personnel, who operate at high altitudes, often incur subconcussive forces to the head. These subconcussive head impacts can be induced by exposure to, for example, flash-bang grenades, artillery fire, recoilless rifle, improvised explosive devices (IEDs), and head collision. The combined effects of these two stressors have the potential to attenuate one's readiness, operational efficiency, and overall brain function, but the combined effects have never been studied to date. As a result, one of four study topics that the Defense Centers of Excellence deems urgent is: Document the effects of altitude exposure on mild traumatic brain injury (mTBI) and blast-induced neurotrauma (BINT). To answer the question, we hypothesized that there will be an exponential worsening in neurocognitive function and in ocular-motor system functioning, and increased plasma expression of brain-derived biomarkers, after subconcussive head impacts under hypoxic conditions.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to dermatology and can be used for treatment of localised psoriasis. That is ensured by applying an electret polymer film on a lesion; between an active surface thereof and an affected skin surface there is an absorbent pad impregnated with a dosage form solution. An electric charge of an applicator is specified to be similar to that of active components of the dosage form. Between the active surface of the applicator and the absorbent pad, there is a protective fluoroplastic film eliminating the fast discharge of the applicator. ^ EFFECT: method allows intensifying diffusion of the dosage form, improving microcirculation, reducing blood viscosity, normalising skin electrical conductivity in the lesion that ensures resolution of "duty" plaques torpid to routine methods of therapy, and also ensuring pharmacoeconomic benefit. ^ 2 ex, 1 dwg, 3 cl
PURPOSE:To obtain the titled preparation by coating a solid drug successively with hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, and polyvinyl acetal diethylaminoacetate, thereby masking the taste and odor, etc. of the solid drug. CONSTITUTION:The titled preparation is obtained by coating a solid drug successively with hydroxypropyl methyl cellulose (HPMC), hydroxypropyl methyl cellulose phthalate (HPMCP) and polyvinyl acetal diethylaminoacetate (PAEA). The coating layers are inert to the drug and mask the taste and odor or the solid drug without thickening the coating layer. An enteric preparation of a drug which can be disintegrated in the stomac can be prepared by adjusting the thickness of the HPMCP layer. It is especially useful for the coating of a  drug having ill odor or giving unagreeable feeling such as bitter or pungent  taste by administration, e.g. tolperisone hydrochloride, methyldopa, etc.
The invention provides a traditional Chinese medicinal composition for treating migraine and general headache. The composition comprises radix aconiti preparata, dahurian angelica root, Manchurian wildginger, honey-fried licorice root, mint and salted plum, and has liver calming, endogenous wind stopping, blood circulation invigorating, collateral dredging, heart calming, mind tranquilizing, yin enriching and kidney nourishing functions through adopting traditional Chinese medicinal right supporting, evil dispelling, yin and yang balancing and blood vessel dredging as theoretic bases. A preparation method of the composition comprises the following steps: drying radix aconiti preparata, dahurian angelica root, Manchurian wildginger, honey-fried licorice root, mint and salted plum, crushing by using a crusher, and sieving by using a 120 mesh sieve to obtain fine medicinal powder for later use. When the composition is clinically used, 3-5g of the fine medicinal powder is taken, and is blended with honey to form a paste, the paste is placed on a medical plaster, and the plaster is plastered on the temple when migraine appears; and the plaster is applied to the forehead when general headache appears. The plaster is applied twice every day, and allows migraine or general headache to be healed after the plaster is continuously applied for 3-10d. Patients in the early stage or middle stage of pathogenesis can be cured only after the plaster is applied for 3-10d, and recurrence is difficult. The composition has the advantages of simple formula, use convenience and unique curative effect.
Breast cancer has become the most prevalent cancer globally, predominantly affecting women, with mastectomy surgery a frequent treatment. Women often experience a discrepancy between their post-mastectomy body, and their former sense of self, affecting negatively on wellbeing. The narratives of eight women who chose to artistically tattoo over their mastectomy scars were explored in this study, through semi-structured interviews and Interpretative Phenomenological Analysis (IPA). Seven master themes are presented. These themes follow the women from a state of disruption (of body image and gender identity) and surgical scarring as the first marking of the body, to the second marking of the body through artistic tattooing, bringing with it transformation, acceptance, feeling heard and connection with the artist, closure and control and the creation of significance and meaning. Viewed through Self-Discrepancy Theory, the findings of this study has implications for psycho-oncology and wellbeing support for women following mastectomy surgery.
Participants are randomized to treatment group. After the first MRI scan, participants are assessed by an independent occupational therapist (before and after intervention) and participate in 10 treatment sessions with a treating occupational therapist. Following the post-treatment assessment, participants have a second MRI scan. Twelve weeks later, participants have a third, follow-up scan.
Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by delivering a cell-killing drug to the tumor cells carrying a tumor-associated protein called folate receptor alpha (FRα). It is being developed for the treatment of subjects with recurrent platinum-sensitive, high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression. Patients will have had at least 2 prior lines of therapy. These will include at least 2 lines of platinum-containing therapy or 1 line with a documented platinum allergy. FRα positivity will be defined by the Ventana FOLR1 (FOLR1- 2.1) CDx assay (Ventana FOLR1 Assay)
Percutaneous drug-eluting bead transarterial chemoembolization, followed by conventional transarterial chemoembolization（cTACE) every 2 months. A total of 3 times of chemoembolization will be performed.
A computer system is provided that communicates with a distributed blockchain computing system that includes multiple computing nodes. The exchange stores an order book and a plurality of digital wallets associated with different clients. The computer system receives new data transaction requests that are added to the order book. A match is identified between data transaction requests and hashes associated with the digital wallets associated with the respective data transaction requests are generated. The counterparties receive the hashes of the other party along with information on the match and each party causes blockchain transactions to be added to the blockchain of the blockchain computing system. The computing system then monitors the blockchain to determine if both sides of the match has been added to the blockchain.
Subjects in the IG will be given non-surgical periodontal treatment comprising of oral hygiene instructions, scaling and root surface debridement. Scaling will be carried out with ultrasonic scaler. For root surface debridement (for sites with PPD \>4mm), local anaesthetic will be administered and ultrasonic scaler and Gracey curettes will be used. The scaling and root surface debridement will be done in 2 sittings over 2 different days within a week. Oral hygiene instructions and additional supportive scaling and root surface debridement will be repeated at 3 months and 6 months if judged necessary (presence of sites with BOP and/or PPD ≥5mm).
1478971 Coated absorbent particles UNIVERSITY OF STRATHCLYDE 24 June 1974 [5 July 1973] 32059/73 Heading B2E [Also in Division Cl] A solute absorptive material comprises composite granules or pellets each having a core of absorbent material capable of absorbing the solute and, enveloping the core, a polymeric membranous coating which is permeable to the solute, wherein the polymeric coating is a copolymer of a first monomer the homopolymer of which is water soluble and a second monomer the homopolymer of which is water insoluble. Suitable first monomers are acrylic acid, methacrylic acid, itaconic acid, acrylamide, hydroxyacrylamide, vinyl pyrrolidone, diethyl- and dimethyl-amino acrylates and methacrylates, and hydroxyethyl methacrylate. Suitable second monomers are esters of methacrylic, acrylic and itaconic acids, acrylonitrile, methacrylonitrile, 2-vinyl pyridine, 2-methyl-5-vinyl pyridine, and styrene. Suitable core material is charcoal, active carbon, alumina, silica gel, ion exchange resins, granulated clay, chalk, starch, molecular sieves, diatomaceous earth, dialdehyde starch, polyacrylic acid, polyethylene oxide, polypropylene oxide, polypropylene glycol, polybenzylpyrrolidone, and p-trimethylammonium, benzaldehyde chloride. The core may be treated with gaseous alkalene oxide. The enveloping membrane may be formed by stirring the granules into a solution of the copolymer then drying them. The particles are useful in dialysis of blood.
For 5 days children will receive a high carb breakfast that will be comprised of 15% protein, 65% carbohydrates and 20% fat. Total energy content, fat, sugar, fiber, energy density, are similar between the breakfast meals.
PURPOSE: The purpose of this research is to further understand the research status and summarize the research hotspots of sleep disorder and cancer, so as to provide insights into future researches.
METHODS: In this research, the publications pertaining to sleep disorders and cancer from 1992 to 2022 was retrieved from SCIE and SSCI databases in the Web of Science Core Collection. The subject, journal, country/regions, institutions, author, and citations of publications were descriptively analyzed and visual analysis.
RESULTS: From 1992 to December 2022, a total of 732 relevant literatures were retrieved from WOS SCIE and SSCI databases, the number of publications showed an increasing trend year by year. These articles were published in 252 journals, and the three most productive journals included Supportive Care in Cancer (80 publications), Psycho-oncology (32 publications), and Journal of Pain and Symptom Management (32 publications). The three most productive countries included the USA (367 publications, 50.1%), China (133 publications, 18.2%), and Canada (97 publications, 13.25%), with total citations of 12,684, 1866, and 5263. The three latest hot keywords in this field were sleep duration, validity, and inflammation.
CONCLUSION: The USA, China, and Canada produced a lot of literature in the research field of sleep disorders and cancer, and had relatively great academic influence from 1992 to 2022. Researchers could pay more attention to the published in journals such as Journal of Clinical Oncology, Sleep, and Supportive Care in Cancer to timely grasp the latest progress and expand the breadth and depth in this area. Looking at the history of tumor and sleep disorder research in the past 20 years, the clinical treatment of sleep disorder caused by tumor and the direct bidirectional mechanism of the two may be a new focus of future research.
Patients taking carbidopa and levodopa alone or with other dopaminergic drugs have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (includes operation of motor vehicles). Road traffic accidents attributed to sudden sleep onset have been reported. Although many patients reported somnolence while on dopaminergic medications, there have been reports of road traffic accidents attributed to sudden onset of sleep in which the patient did not perceive any warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event. Sudden onset of sleep has been reported to occur as long as one year after the initiation of treatment.

Falling asleep while engaged in activities of daily living usually occurs in patients experiencing preexisting somnolence, although some patients may not give such a history. For this reason, prescribers should reassess patients for drowsiness or sleepiness especially since some of the events occur well after the start of treatment. Prescribers should be aware that patients may not acknowledge drowsiness or sleepiness until directly questioned about drowsiness or sleepiness during specific activities. Patients should be advised to exercise caution while driving or operating machines during treatment with carbidopa and levodopa. Patients who have already experienced somnolence or an episode of sudden sleep onset should not participate in these activities during treatment with carbidopa and levodopa.

Before initiating treatment with carbidopa and levodopa, advise patients about the potential to develop drowsiness and ask specifically about factors that may increase the risk for somnolence with carbidopa and levodopa such as the use of concomitant sedating medications and the presence of sleep disorders. Consider discontinuing carbidopa and levodopa in patients who report significant daytime sleepiness or episodes of falling asleep during activities that require active participation (e.g., conversations, eating, etc.). If treatment with carbidopa and levodopa continues, patients should be advised not to drive and to avoid other potentially dangerous activities that might result in harm if the patients become somnolent. There is insufficient information to establish that dose reduction will eliminate episodes of falling asleep while engaged in activities of daily living.