anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators of nucleosomal remodeling that are commonly mutated in several cancers, including germinal center (GC)-derived B cell lymphomas. However, the specific roles of different BAF complexes in GC B cell biology are not well understood. Here we show that the AT-rich interaction domain 1a (Arid1a) containing canonical BAF (cBAF) complex is required for maintenance of GCs and high-affinity antibody responses. While Arid1a-deficient B cells undergo initial activation, they fail to sustain the GC program. Arid1a establishes permissive chromatin landscapes for B cell activation and is concomitantly required to suppress inflammatory gene programs. The inflammatory signatures instigated by Arid1a deficiency promoted the recruitment of neutrophils and inflammatory monocytes. Dampening of inflammatory cues through interleukin-1β blockade or glucocorticoid receptor agonist partially rescued Arid1a-deficient GCs, highlighting a critical role for inflammation in impeding GCs. Our work reveals essential functions of Arid1a-dependent cBAF in promoting efficient GC responses.
The embodiments of the invention provide an intelligent shared cryogenic physical therapy system, including cryogenic physical therapy devices, human-machine interaction devices and a server. The server is configured to acquire target location information and recommend a cryogenic physical therapy device based on a relationship between the target location information and pre-recorded location information of each of the cryogenic physical therapy devices; and send a use request to a human-machine interaction device when a target cryogenic physical therapy device is selected and it is determined that the account balance meets a fee deduction condition. The human-machine interaction device can acquire the use request and generate the control instruction. A programmable controller of the cryogenic physical therapy device is configured to control the physical therapy module to perform an operation indicated by the control instruction when receiving the control instruction. After finishing the cryogenic physical therapy, the human-machine interaction device is configured to send a fee deduction request to the server, so that the server can update the account balance when receiving the fee deduction request. The user does not need to go to a specific service merchant, and can select a suitable cryogenic physical therapy device according to actual conditions.
The lateral wedge plus medial support orthotic will be custom-made and designed using a 3D volumetric cast of the foot with the participant's foot in a subtalar joint neutral position. The cast will be balanced so that it rests in a neutral position then smoothed to address any irregularities and to allow for soft tissue splay. Polypropylene sheets of 3mm or 4mm thickness will be vacuum formed or milled directly to produce a ¾ length shell. An ethyl-vinyl-acetone (EVA) lateral post in the heel and forefoot of 5 degrees will be incorporated into the orthotic. The orthotic will be finished with a neoprene cover for improved comfort and patient compliance.
Project method: This study will be implemented on 20 patients aged 35-60 years referring to Department of Prosthetic Dentistry of Mashhad Dental School. The patients are selected according to the RDC/TMD criteria to include those having temporomandibular osteoarthritis with unknown etiology. The patients will be asked to take cone beam CT of temporomandibular joint to evaluate any changes in morphology of the TMJ. The patients will be randomly assigned to two groups: Group 1 (treatment group) will receive low level laser therapy. The laser light will be applied with 890 nm diode laser (Mustang 2000+, Russia) with frequency of 1500 Hz, and dose of 2 J/cm2 per point in the joint area and painful muscles if any. In Group 2 (placebo) the low power laser will be applied with a minimal dose that is very lower than the threshold necessary for therapeutic effects. Laser therapy for both the treatment and placebo groups will be applied in the back, front, and above the mandibular condyles and inside the external auditory meatus and also on painful muscles three times a week for four weeks. Patients will be evaluated at the start of the treatment, after the 6th and 12th sessions of laser therapy and also one month after the end of the treatment. At each evaluation, the pain level in opening the mouth and masticatory muscle tenderness will be measured according to the Visual Analogue Scale (VAS). The range of lateral and protrusive mandibular movements, the difficulty in chewing food and the the presence or absence of sound joints will also be evaluated. One year after treatment, the patients will be referred for taking the second cone beam CT of the TMJ to seek any change in morphology of the joint.
The No-training intervention group does not involve any specific training program. Instead, participants assigned to this group will receive weekly phone calls, similar to the other groups, to answer the same questions as the other groups concerning their mental and emotional states and maintain regular contact throughout the 6-week study duration.
Participants will have a dose of EMLA Cream applied to the venipuncture site 1 hour before the procedure. Dosage based on age and weight: 4-6 years old and heavier than 10kg will receive 10g of EMLA; 7-12 years old and more than 20kg will receive 20g of EMLA.
Control subjects individually matched to linezolid subjects (on age, gender and type of infection) who received at least 6 weeks of antibiotics other than linezolid. Control group assessed only at baseline visit to assess presence of background abnormalities in the study test panel.
1376136 Hair curling L'OREAL 11 Nov 1971 [12 Nov 1970] 52433/71 Heading A4V [Also in Divisions A5, H3-5] A process for the treatment of fibres e.g. artificial fibres or human hair, comprises placing them in a cavity resonator formed by a curling iron, curler or hair drying hood which has been matched both to the generator and to the transmission line from the generator. As shown in Fig. 2 a hair curler comprises a two part separable casing one part of which consists of a perforated metal end wall 4 secured to an insulating cylinder 3 on which hair 12 is wound and the other part of which consists of perforated metal cylinder 6 and perforated end wall 7. In this embodiment matching is achieved by a coupling component 10 in the form of a coil which is connected to the central conductor and outer screen of a coaxial cable 13. The natural frequency of the casing resonator formed by the two part casing is reduced to correspond to that of the generator by means of a helical conductor 9 wound on cylinder 3 and secured at one end 9b only to the casing. Alternatively coil 9 need not be connected to the casing or it may be connected at one or more spaced points. In Fig. 3 (not shown) the matching coupling is in the form of rectilinear conductor connected to the central conductor of the coaxial cable. In Fig. 4 (not shown) the matching coupling is in the form of an antenna connected to the core of the coaxial cable. To compensate for the decrease in dielectric loss factor of hair as it dries a cylinder of a material whose dielectric loss factor and constant increase with temperature is provided around insulating cylinder 3. In Fig. 6 (not shown) the device is in the form of a curling iron, the conductive envelope comprising two pivoted half shells which may be opened and closed by means of levers. In Figs. 8, 9, 10 (not shown) the device comprises a central core which forms the coupling component, a roller on which the hair is wound and which can optionally incorporate frequency matching means and a two part pivoted conductive shell. The coupling component comprises two coils connected to the central conductor of the coaxial cable and via a by-pass condenser to earth. Various chemical and heat treatment processes are described in detail.
For herpes zoster (HZ) infection, early diagnosis and treatment are important in order to shorten the course of the disease and reduce sequelae, however, there is a lack of non-invasive diagnostic methods. Reflectance confocal microscopy (RCM) is a non-invasive technique often used to diagnose dyspigmented dermatosis, skin tumours, human papillomavirus infectious dermatosis, etc. To evaluate the clinical value of RCM for the early diagnosis of HZ. We collected RCM images from 30 HZ patients with typical vesicles in order to analyse their features. We then utilized RCM to analyse early lesions of another 12 HZ patients, who presented with localized erythema or papules, but not typical vesicles. In addition, we recruited one patient with HZ and observed the lesions over 14 days also using RCM. RCM images showed that the typical lesions of HZ mainly involved oedema of the spinous layer, intraepidermal blister formation, ballooning multinucleated giant (BMG) cells, and dermal papillary oedema. Among them, BMG cells were of specific diagnostic value. Early lesions of HZ patients without typical vesicles showed BMG cells under RCM. A few BMG cells were observed during the early stage of HZ. However, the number of BMG cells increased significantly as typical clustered blisters gradually appeared in the lesions. With the regression of the lesions, the number of BMG cells decreased gradually. RCM, with the advantages of being non-invasive, rapid, and convenient, has an important role in monitoring the evolution of HZ.
The present disclosure provides a metal based dental article and a method of forming the metal based dental article. The metal based dental article includes a base layer, a first coating on the base layer and a second coating on the first coating. The base layer is formed from a metal substrate selected from the group consisting of a stainless steel, a titanium alloy or a nickel titanium alloy. The first coating is formed from a metal selected from the group consisting of nickel, a nickel alloy, copper, a copper alloy, zinc, a zinc alloy, tin, a tin alloy, gold or a gold alloy, where one of the first coating or the surface of the base layer has a surface roughness (R a ) from 0.1 to 1.0 microns as measured according to ASTM B46.1-2009. The second coating is formed from a metal selected from the group consisting of rhodium, a rhodium alloy, ruthenium, a ruthenium alloy, cobalt, a cobalt alloy, palladium, or a palladium alloy. The second coating has a predetermined thickness that provides the metal based dental article with a matte finish and a whiteness, L*, of at least 80 of the CIELAB color system (L*, a*, B*). t,?
A medical image diagnosis apparatus and a medical image diagnosis system efficiently perform imaging for differential diagnosis. The medical image diagnostic apparatus includes an imaging unit, a storage unit, an acquisition unit, and an output control unit. The imaging unit images the subject by the 1 st scan. The storage unit stores, for a plurality of disease patterns, correspondence between the disease pattern and a plurality of scans for differential diagnosis of the disease pattern. The acquisition unit acquires a disease pattern having a matching possibility and a 1 st index value indicating a degree of matching possibility of the disease pattern, based on 1 st image data obtained by the 1 st scan. The output control unit outputs information indicating the disease pattern to a display when differential diagnosis of the disease pattern is possible based on the 1 st index value, and outputs imaging conditions for causing the imaging unit to image the subject by a 2 nd scan different from the 1 st scan based on the correspondence relationship and the disease pattern that is likely to match when the differential diagnosis is not possible based on the 1 st index value.
For patients with MRD+ and without grade II/\>II aGVHD by day +60 post-transplantation, DLI was given once by day +60 and was then administered based on MRD and GVHD status. If patients were MRD negative, DLI was not given again; if patients were MRD positive and without GVHD, DLI was given monthly until GVHD occurred or MRD became negative or for a total of four times. For patients with NR or PR pre-transplantation and with MRD negative by day +60 post-transplantation, DLI was given once by day +90 regardless of MRD, and was then administered when MRD became positive. For patients with CR pre-transplantation and with MRD negative post-transplantation, DLI was not given unless MRD became positive.
The incidence of breast cancer in Chinese women is lower than that of a Western population. Breast cancer is the most common cancer in Chinese women and the incidence is rising. Moreover there are more premenopausal women with breast cancer where the breast cancer incidence peaks in the forties and the postmenopausal rise in incidence is less commonly seen. As the genetic predisposition to breast cancer is increasingly understood, it has been suggested that the differences in breast cancer incidence in different ethnic populations is potentially due to interactions between lifestyle and genetic characteristics. To date, the use of Agendia's gene expression assays in Chinese women has not been studied. In this study, the feasibility of the gene-expression prognostic assays for risk assessment in this specific group will be assessed. Moreover, the specific molecular characteristics and potential biomarkers will be studied, focusing especially on the large group of premenopausal breast cancer patients.
Obese patients with dysglycemia or not, from the Obesity Outpatient Clinic, and individuals with normal or overweight weight with dysglycemia or not, preferably from the same social class and type of diet of the obese will be invited to participate in the study. Dysglycemia will be defined by the criteria of the Brazilian Society of Diabetes. These individuals will be divided into four groups: obese with dysglycemia (OBD), obese with normoglycemia (OB), lean / overweight with dysglycemia (MD) and lean with normoglycemia (M). After the selection and signing of the informed consent, the patient will be referred for an anthropometric evaluation, with the measurement of body mass and height, waist circumference and determination of body fat by the bioimpedance method Biodynamic 450 (BioDynamics , Seattle, USA). Finally, the 24-hour reminder (R24h) will be applied as a food survey method. And the dietary calculation will be performed through the AVANUTRI® diet calculation program (Rio de Janeiro, Brazil). Clinical parameters will include: age, sex, BMI, presence of comorbidities, use of medications, gastrointestinal complaints, previous surgeries and smoking (absent, present, prior). Only after approval by the Research Ethics Committee (CEP) of the Pedro Ernesto University Hospital (HUPE-UERJ), will this recruitment begin.
A hair foil and hair holding system for applying hair treatments has a hair anchoring strip close to or aligned with the leading edge of a foil (40) or a hair holding appliance, by which it is adhered to the scalp in a hand free, non lifting relationship. The strip (45) may be the hook component of a hook and loop fastener system. The leading edge (42) may be pinked to provide a pattern of slots (43) for picking and placing hair strands on the foil. The appliance may have provision for attaching a foil blank. The foils may have shoulders (47) extending out wider than the leading edge is long. The foils may have flaps (46) to aid in urging them forward with a pick during usage. The foils or appliances may be made from continuous webs of leading edge or foil material and hair anchoring material.
Chronic kidney disease (CKD) affects approximately 14% of adults in the United States and is present in at least 10% of the population worldwide. Blood glucose and blood pressure control are imperative to adequately manage CKD as they are the only primary prevention measures for the condition. Recent changes in CKD evaluation and medication therapies that modify disease progression and aid in managing complications such as anemia of CKD have emerged, including a newly approved mineralocorticoid receptor antagonist and hypoxia-inducible factor-prolyl hydroxylase inhibitor, respectively. This focused update on CKD evaluation and management will review the most recent evidence and approved agents to support patients with CKD, including a review of glomerular filtration rate measurement methods such as CKD-EPI 2021 and utilization of cystatin C, Kidney Disease Improving Global Outcomes (KDIGO) guidelines, American Diabetes Association (ADA) guidelines, and primary literature supporting the use of newer agents in CKD. Checklists for managing blood pressure and blood glucose, CKD-mineral bone disorder, and anemia of CKD targeted for pharmacists are also provided. Additionally, a discussion of Centers for Medicare & Medicaid (CMS) coverage of agents approved for managing complications of CKD is included.
Variants in KCNMA1, encoding the voltage- and calcium-activated K+ (BK) channel, are associated with human neurological disease. The effects of gain-of-function (GOF) and loss-of-function (LOF) variants have been predominantly studied on BK channel currents evoked under steady-state voltage and Ca2+ conditions. However, in their physiological context, BK channels exist in partnership with voltage-gated Ca2+ channels and respond to dynamic changes in intracellular Ca2+ (Ca2+i). In this study, an L-type voltage-gated Ca2+ channel present in the brain, CaV1.2, was co-expressed with wild type and mutant BK channels containing GOF (D434G, N999S) and LOF (H444Q, D965V) patient-associated variants in HEK-293T cells. Whole-cell BK currents were recorded under CaV1.2 activation using buffering conditions that restrict Ca2+i to nano- or micro-domains. Both conditions permitted wild type BK current activation in response to CaV1.2 Ca2+ influx, but differences in behavior between wild type and mutant BK channels were reduced compared to prior studies in clamped Ca2+i. Only the N999S mutation produced an increase in BK current in both micro- and nano-domains using square voltage commands and was also detectable in BK current evoked by a neuronal action potential within a microdomain. These data corroborate the GOF effect of N999S on BK channel activity under dynamic voltage and Ca2+ stimuli, consistent with its pathogenicity in neurological disease. However, the patient-associated mutations D434G, H444Q, and D965V did not exhibit significant effects on BK current under CaV1.2-mediated Ca2+ influx, in contrast with prior steady-state protocols. These results demonstrate a differential potential for KCNMA1 variant pathogenicity compared under diverse voltage and Ca2+ conditions.
PURPOSE: To obtain a vaccine capable of remarkably preventing a microorganism belonging to the genus Streptococcus and having the dental caries-inducing ability, from sticking to surfaces and fissures of teeth without any side effects by extracting a ciliary antigen from the bacterium by a specific method. CONSTITUTION: A microorganism belonging to the genus Streptococcus and having the dental caries-inducing ability [preferably a Streptococcus mutans variant strain K-Dp (FERM P-317), etc.] is initially cultured in a culture medium and the cultured microorganism is then suspended in a neutral hypertonic buffer solution [e.g. a 1M saline solution buffered with 0.1-1M acetic acid and sodium acetate (pH6-7.8)] to extract a ciliary antigen. Thereby, the objective vaccine is obtained. The microorganism is preferably cultured at pH5.6-8 and 23-39 deg.C under anaerobic conditions. Ultrasonic treatment is preferably carried out in suspending the microorganism in the hypertonic buffer solution and extracting the antigen. Furthermore, the vaccine in a volume of, e.g. 0.2-1ml at a time is preferably injected into a mucous membrane in the oral cavity.
AIMS: Heart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance for improved therapy. Congestion, a key factor in HF-related hospitalizations, further underscores the need for timely interventions. Proactive monitoring of intracardiac pressures, guided by pulmonary artery (PA) pressure, offers opportunities for efficient early-stage intervention, since haemodynamic congestion precedes clinical symptoms.
METHODS: The BioMEMS study, a substudy of the MONITOR-HF trial, proposes a multifaceted approach integrating blood biobank data with traditional and novel HF parameters. Two additional blood samples from 340 active participants in the MONITOR-HF trial were collected at baseline, 3-, 6-, and 12-month visits and stored for the BioMEMS biobank. The main aims are to identify the relationship between temporal biomarker patterns and PA pressures derived from the CardioMEMS-HF system, and to identify the biomarker profile(s) associated with the risk of HF events and cardiovascular death.
CONCLUSION: Since the prognostic value of single baseline measurements of biomarkers like N-terminal pro-B-type natriuretic peptide is limited, with the BioMEMS study we advocate a dynamic, serial approach to better capture HF progression. We will substantiate this by relating repeated biomarker measurements to PA pressures. This design rationale presents a comprehensive review on cardiac biomarkers in HF, and aims to contribute valuable insights into personalized HF therapy and patient risk assessment, advancing our ability to address the evolving nature of HF effectively.
The main hypothesis the investigators will test is that changes in myocardial blood volume, under physiologic stress, correlate with myocardial flow reserve as measured in low spatial resolution nuclear SPECT scans. Secondary hypothesis is that stress perfusion as quantified with bolus height corrected gadofosveset trisodium images, better correlate with SPECT perfusion than uncorrected, relative perfusion values.

The investigators propose implementing the scan protocol using a 1.5T or 3.0T MRI scanner. The investigators will scan a series of 20 patients recruited from the nuclear stress lab at Northwestern Memorial Hospital. These subjects will be approached and enrolled into a HIPPA Compliant, IRB approved research study to assess the effectiveness of myocardial perfusion and blood volume images to measure myocardial blood volume. Subjects will be scanned with a modified version of the clinical stress-perfusion protocol. Correlation analysis will be used to test the hypothesis that quantitative blood volume is an indicator of myocardial flow reserve.
Amino-esters of the formula R.CO.O.A.NR1 R11 (in which R is a monohalogenophenoxymethyl, 2-methyl-4-chloro-phenoxymethyl, naphthoxymethyl or indolyl-methyl group, A is an alkylene radical of at most 4 carbon atoms, and R1 and R11 are aliphatic radicals of at most 4 carbon atoms or benzyl radicals, or-NR1 R11 is a saturated heterocylic radical which may include another hetero-atom, or R1 may be an alkylene chain attached to A in which case R11 has any of the values specified above) are prepared by reacting in an anhydrous organic medium one mole of a halide of the appropriate acid with one or two moles of the appropriate amino-alcohol, or by reacting the free acid with an halogenated amine corresponding to the amino-alcohol.  The products may subsequently be converted to acidaddition salts of quatenary derivatives with alkyl halides. Specified values of R1 and R11 are methyl, ethyl, beta-hydroxy-ethyl, betahalogeno-ethyl, beta-cyano-ethyl, propyl, isopropyl, allyl and benzyl, or-NR1R11 may be alkylene-imino, morpholino, piperazino, N1-methyl-piperazino or, for example, N-R11-piperidyl. Examples are given.  2-Methyl-4-chloro-phenoxyacetic acid chloride is prepared from the acid and thionyl chloride. Parachloro-phenoxy-acetic acid chloride is prepared similarly.  The compounds of the invention, which are stated to exert a stimulating action on the central nervous system, may be made up into pharmaceutical compositions with suitable carriers. Cachets and aqueous solutions of the beta-dimethylaminoethyl ester hydrochloride of p-chlorophenoxyacetic acid for oral administration or intravenous or intramuscular injection are described.