anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Archery can be described as a comparatively static sport requiring strength and endurance of the upper body, in particular the forearm and shoulder girdle. Skill in archery is defined as the ability to shoot an arrow to a given target in a certain time span with accuracy. The discipline is described as a three-phase (the stance, the drawing and the sighting) movement. Shooting can be divided these phases into six: bow hold, drawing, full draw, aiming, release and follow-through. Each of these phases represented a stable sequence of movements and was ideal for studying the motor control and skill acquired during this voluntary kinematic process.

An archer pushes the bow with an extended arm, which is statically held in the direction of the target, while the other arm exerts a dynamic pulling of the bowstring from the beginning of the drawing phase, until the release is dynamically executed. The release phase must be well balanced and highly reproducible to achieve commendable results in a competition.

The bowstring is released when an audible impulse is received from a device called "clicker" that is used as a draw length check. Each arrow can be drawn to an exact distance and a standard release can be obtained using the device. The clicker is reputed to improve the archer's score and used by all target archers. The archer should react to the clicker as quickly as possible. In particular, a repeated contraction and relaxation strategy in the forearm and pull finger muscles should be developed for this reason.

The aim of this study was to investigate the effect of stabilization and stabilization-related parameters on shooting performance at the cervical, lumbal and scapular levels in archery athletes. A total of 40 archery athletes aged between 10 and 18, who have been professionally engaged in archery for at least 1 year were included in the study. Demographic information and musculoskeletal system evaluations of the athletes were done. Performance of the athletes via Upper Extremity Closed Kinetic Chain Stability Test, Hand Grip Strength test; presence of scapular dyskinesia was evaluated via the Lateral Scapular Slide Test. Cervical region stabilization was evaluated via Craniocervical Flexion Test, scapular level stabilization was evaluated via Scapular Muscle Endurance Test, lumbar region stabilization was evaluated via Abdominal Drawing-in Test and Sahrmann's Core Stability Test. As the parameters related to stabilization, postures via Corbin Postural Rating Scale; balances via Stork Balance Test, Upper Extremity Y Balance Test; pain was evaluated via the Shoulder Pain and Disability Index. Shooting performances were evaluated with 72 target shootings and a total of 720 points. .
During one of the four occasions participants visit the lab they will receive L-DOPA combined with carbidopa (50-200mg L-DOPA/50mg carbidopa). Neurophysiology outcome measures will be obtained at 30, 60, 90, 120 and 150 min post drug-intake.
Patients who are randomized to this arm will be allowed discharged home for 12 hours after fetal status is assessed and noted to be reassuring with the foley bulb in place. They will return sooner if they experience rupture of membranes or enter active labor or if the foley bulb falls out.
Trained LHWs will oversee the screening and brief intervention procedures (i.e., the 5As). A culturally acceptable standardized form will be integrated into intake procedures within the HIV that will allow for the documentation and results of using the 5As. The first "A" will be the screening question where the LHW will "Ask" study participants about smoking. When a participant reports being a smoker, the LHW will proceed to the next 3 "A"s (Advise, Assess, Assist). These 3As will constitute the brief intervention. The LHW will utilize motivational enhancing discussion between the study participant with a focus on increasing insight and awareness regarding smoking and motivation toward behavioral change. For those participants who are motivated for treatment, a referral will be made to a clinic nurse practitioner for evaluation for treatment with varenicline.
The present invention relates to compositions and methods that enhance the engraftment potential of stem cells. The compositions comprise at least one microRNA agent, such as a microRNA mimic, or a microRNA inhibitor. The compositions may comprise a mixture of at least one microRNA mimic and at least one microRNA inhibitor. The methods include transfecting various stem cells with at least one of these micro RNA agents so as to cause either a gain of function, or a loss of function. Any stem cell may be used, such as embryonic stem cells, adult stem cells, induced pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, or neuronal stem cells. A preferable stem cell is a hematopoietic stem cell.
Subarachnoid hemorrhage (SAH) or bleeding in the brain is a form of stroke. SAH mostly results from ruptured aneurysms. This severe disease often results in death or severe physical or cognitive disabilities and reduced quality of life. One frequent complication after SAH is cerebral vasospasm, a spasm of the big arteries accompanied by infarction of healthy brain tissue. The pathophysiologic processes which drive vasospasm remain unclear. This study aims to examine the role of endocannabinoids and cortisol in cerebrospinal fluid during the development of cerebral vasospasm. Additionally, this study examines whether side difference in the processed electroencephalogram (bilateral bispectral index) may be useful for early detection of cerebral vasospasm.
BACKGROUND: Sexual dysfunction is frequent in female hemodialysis patients and is related to poorer quality of life. It is often a neglected topic associated with marked distress and interpersonal difficulties.
OBJECTIVE: Few studies are reported from Sub-Saharan African Countries (SSA) regarding female sexual dysfunction (FSD) in (HD) patients. The study aims to explore the prevalence and associated factors of FSD in female HD at a sole dialysis centre in Somalia.
METHOD: Over a one-month period, a cross-sectional study was conducted among women with end-stage renal disease aged 18-50 years who were undergoing a dialysis program for at least three months at the dialysis center of our hospital. The participants were married, and they were living with their partners. Data regarding the sociodemographic features, clinical characteristics, frequency of sexual intercourse per week, and the Female Sexual Function Index (FSFI) scores were collected using a standard face-to-face interview questionnaire.
RESULTS: During the study period, a total of 115 participants were eligible for the study's inclusion criteria. The mean patient age was 38.5 ± 9.3 years. The most common cause of ESRD was diabetes, which accounted for 53%, followed by hypertension (26.1%) and glomerulonephritis (9.6%). The mean duration of dialysis was 2.9 ± 1.4 years, and approximately two-thirds of the participants (62.5%) were in the program for more than three years. Regarding the frequency of sexual intercourse, 61.7% of female participants performed sexual intercourse less than once time/a week. The prevalence of FSD was 92.2% (n = 106) of all participants. The mean FSFI score of the participants was 16.05 ± 4.48. Longer duration of dialysis program (i.e., more than four years), increasing age (i.e., > 35 years), those with diabetes had scored lower overall FSFI scores.
CONCLUSION: The prevalence of female sexual dysfunction among Somali female hemodialysis patients was very high, representing a significant problem in end-stage renal disease (ESRD). Our study findings revealed that increasing age, diabetes, and duration of dialysis negatively impact female sexual function and are significantly associated with FSD.
The utility model relates to a multi-purpose paste for treating skin diseases, which is suitable for inner and outer injury. The utility model is provided with an adhesive layer coated on base cloth; the middle position of the base cloth is provided with a groove; pills are arranged in the groove; a layer of separation paper is coated outside the pills. When the utility model is used, the paste is torn off and the pills are taken out. Then, the pills are soaked in boiled water for softening. The pills are squeezed into the corresponding shape with the infection site and are pasted on the affected part. Then the base cloth is covered to protect the pills. The utility model has the advantages that the pills can directly acted on the affected part. Besides, the utility model has the advantages of high medicine effect and ideal effect on skin diseases.
Certain embodiments of the present invention provide a system and method for prioritizing medical imaging scans. An image acquisition device, such as a computerized tomography (CT) system, an ultrasound system, an electron beam tomography (EBT) system, a magnetic resonance (MR) system and the like, generates medical imaging scans. A computer aided diagnosis application manager may be used to select a computer aided diagnosis application based on information associated with an imaging scan. The imaging scan may be examined with the computer aided diagnosis application. If the examination of the imaging scan indicates the imaging scan contains urgent findings, the imaging scan may be identified as priority. The indication of the imaging scan as priority may be communicated to a physician so the physician may review the priority imaging scan before non-priority imaging scans.
OBJECTIVES: This study aimed to conduct a retrospective study to identify inflammatory biomarkers for predicting ventilator-associated pneumonia in elderly patients.
METHODS: Our retrospective study included 265 elderly patients (age ≥60 years) undergoing abdominal surgery with tracheal intubation and general anesthesia, with 93 experiencing varying degrees of ventilator-associated pneumonia during hospitalization, and 172 without. Serum concentrations of serum amyloid A (SAA), toll-like receptor 4 (TLR4), and soluble myeloid triggering receptor 1 (sTREM-1) were measured at 24 h post-operation using enzyme-linked immunosorbent assay. Comparisons of SAA, TLR4, and sTREM-1 and other risk factors at 24 h post-operation between elderly patients with and without ventilator-associated pneumonia were performed.
RESULTS: The study revealed a 35.1% incidence of postoperative ventilator-associated pneumonia among elderly patients. Upregulations of SAA, TLR4, and sTREM-1 were observed in patients with ventilator-associated pneumonia. Chronic obstructive pulmonary disease, smoking, and tracheal intubation were identified as independent risk factors. The joint prediction model was demonstrated with superior predictive accuracy (area under the curve = 0.89) compared to individual biomarkers. Correlations with procalcitonin further supported the predictive potential of SAA, TLR4, and sTREM-1 in an inflammatory response.
CONCLUSIONS: SAA, TLR4, and sTREM-1, particularly when combined, serve as valuable prognostic indicators for postoperative ventilator-associated pneumonia in elderly patients undergoing abdominal surgery with tracheal intubation and general anesthesia. The joint prediction model offered a promising tool for early risk assessment.
OBJECTIVE: This study aimed to establish a model based on Multi-detector Computed Tomography (MDCT), 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT), and clinical features for predicting different growth patterns of preoperative Invasive Adenocarcinoma (IAC).
METHODS: This retrospective study included 357 patients diagnosed with IAC who underwent surgical treatment. According to pathological subtypes, IAC was classified into low-risk growth patterns (lepidic, acinar) and high-risk growth patterns (papillary, micropapillary, and solid). The clinical features of patients, preoperative MDCT, and 18F-FDG PET imaging characteristics were collected. Logistic regression analysis was used to determine the independent risk factors for the high-risk growth pattern of IAC and construct models for predicting the high-/low-risk growth patterns of IAC. Receiver operating characteristics and calibration curves were plotted and Decision Curve Analysis (DCA) was performed to evaluate the performance and clinical benefits of the models, respectively.
RESULTS: Gender, tumor location, size, spiculation, and SUVavg were independent risk factors for high-risk growth patterns of IAC. The PET/CT imaging- clinical characteristics combined model could well identify high-/low-risk growth patterns of IAC (AUC=0.789), which outperformed the CT model (AUC=0.689, p=0.0012), PET model (AUC=0.742, p=0.0022), and clinical model (AUC=0.607, p<0.0001). The calibration curve indicated good coherence between all model predictions and actual observations in both training and test sets (p>0.05). DCA revealed the highest clinical benefit of PET/CT imaging-clinical characteristics combined model in identifying the high-risk growth pattern of IAC.
CONCLUSION: The PET/CT imaging-clinical model based on multiphase MDCT features, 18F-FDG PET features, and clinical characteristics could predict the high-risk growth pattern of IAC preoperatively, aiding clinicians in deciding personalized treatment strategies.
Apparatus 1 for the transformation of fluids, particularly water, comprises a generally ovoid container made primarily of copper. Preferably, the internal fluid-contacting surface of the container has a silver coating. The container may be substantially free of ferrous metal and can comprise two half shells 2, 3. A method of positioning the apparatus comprises the steps of divining, preferably by dowsing, the location and orientation of a tachyon beam 8 striking the earth and subsequently positioning the apparatus within the tachyon bean. The major axis 11 of the apparatus can be oriented at an angle of between 15 and 20Â° to the angle of the tachyon beam, whilst the centre of gravity of the apparatus may be located at a height of between 50 and 75 cm from the surface 10 of the earth. A method of treating water by placing the water in such a positioned apparatus is claimed, wherein the apparatus is left in position for at least a day. The use of such treated water in medicine, particularly for relief of the symptoms of diarrhoea, malaria or HIV infection is also claimed.
The present invention discloses a spray drying process characterized by the continuous preparation and immediate spray drying of a solution comprising at least one active pharmaceutical ingredient and/or at least one excipient and at least one solvent. The one or more active pharmaceutical ingredients and the one or more solvents are combined, alone or with one or more excipients, to form a first suspension. The suspension is continuously fed to a booster pump that pushes the suspension through at least one micro-reaction chamber and/or at least one micro-channel, wherein the solid components of the suspension are dissolved in the solvent by high energy mixing/forced contact at the micro-, nano-and molecular level to form a solution stream. The solution stream is then immediately and continuously fed to a spray dryer through at least one atomizing nozzle, the atomized stream is dried to obtain solid particles and the solid particles are collected. Also disclosed are single or multi-component particles, particulate amorphous solid dispersions and pharmaceutical compositions. The invention also discloses amorphous solid dispersions obtained by the process of the invention and pharmaceutical compositions comprising them.
The research design and methodology of this study are meticulously crafted to explore the complex interplay between acute stroke, hyperglycemia, and their impact on mortality and morbidity. This study adopts a prospective cohort design, following a systematic approach inspired by the Critical Appraisal Skills Programme (CASP) cohort study guidelines and adhering strictly to the STROBE (Strengthening the reporting of observational studies in epidemiology), reporting standards. By implementing a quantitative research method, the study aims to provide high-quality evidence through structured and transparent methodology.

The study focuses on individuals presenting with acute stroke in the Emergency Department (ED) of Tribhuvan University Teaching Hospital (TUTH). The high patient volume and the availability of advanced diagnostic tools like CT scans make TUTH's ED an ideal setting for this research. According to internal audits, TUTH's ED receives a significant number of acute stroke patients, ensuring a robust sample for the study. The study will specifically examine acute stroke patients with concurrent hyperglycemia, utilizing a systematic random sampling technique to ensure representative and unbiased selection. The sample size was calculated using proportions from previous international studies, with adjustments for potential loss to follow-up. The final sample size is set at 60 participants, evenly divided between those with hyperglycemia and those with normal glycemic levels, allowing for meaningful comparisons.

The study's dependent variables are mortality and morbidity, assessed at short-term (1 month), mid-term (3 months), and long-term (1 year) intervals. Independent variables include demographic characteristics, clinical history, and laboratory parameters. Matching based on age, sex, stroke type, and other relevant variables is essential to minimize confounding, enhancing the validity and reliability of the study's findings. Data collection will involve chart reviews for baseline characteristics and clinical history, followed by face-to-face interviews at 1 month, 3 months, and 1 year for follow-up assessments. Laboratory analyses will be conducted for blood glucose levels, and CT scans will be utilized to confirm stroke diagnoses and assess severity. Mortality will be tracked within specified time frames, while morbidity will be assessed using the Modified Rankin Score (MRS). Clinical variables such as vital signs, GCS score, and BEFAST criteria will be recorded meticulously. Hemorrhagic and ischemic strokes will be evaluated using specific criteria, including the The intracerebral hemorrhage (ICH) score and The NIH Stroke Scale/Score (NIHSS), respectively. Participants will be recruited through a systematic process at the triage registration desk, with initial assessments based on BEFAST criteria and additional clinical signs. Blood glucose levels will be measured, followed by CT imaging to confirm stroke diagnoses. This structured flow ensures the accurate identification of eligible participants and the collection of relevant data for analysis.
Concurrent three-dimensional conformal radiation therapy (3DCRT) and radiosensitizing chemotherapy (CT) consisting of either cisplatin alone or the combination of mitomycin and 5-fluorouracil. Protocol treatment must begin with 15 weeks after a transurethral resection of the tumor (TURBT).
BACKGROUND AND PURPOSE: Vortioxetine, a multimodal-acting antidepressant, has recently shown analgesic properties. We aimed to investigate its prophylactic effect in the osteoarthritis (OA) model and gain insights into the underlying molecular mechanisms. Duloxetine was studied as a reference.
EXPERIMENTAL APPROACH: In the monoiodoacetate (MIA)-induced rat model of knee OA, pain-related behaviour was assessed in weight-bearing and Von Frey tests. Antidepressants were administered orally once daily for 28 days. Gene expression of pain-related mediators (Ngf, Il-1β, Tnf-α, Bdnf, and Tac1 encoding substance P) and oxidative stress parameters were determined after completion of the treatment/behavioural testing protocol.
KEY RESULTS: Vortioxetine and duloxetine dose dependently reduced weight-bearing asymmetry and mechanical hyperalgesia of the paw ipsilateral to the MIA-injected knee. Vortioxetine reduced the increased Ngf mRNA expression in the MIA-injected knees to the level in sham-injected counterparts. It reduced oxidative stress parameters in the affected knees, more effectively in females than males. Duloxetine showed no effect on Ngf mRNA expression and oxidative stress. Both antidepressants decreased mRNA expression of pain-related mediators in the lumbar L3-L5 ipsilateral DRGs and spinal cords, which were up-regulated in MIA-injected rats. This effect was male-specific.
CONCLUSION AND IMPLICATIONS: Vortioxetine may be effective against the development of chronic pain in OA. Its antihyperalgesic effect may be mediated, at least in part, by normalization of NGF expression in the affected joint. Decrease of localized oxidative stress and of expression of pain-related mediators that contribute to central sensitization are also involved in vortioxetine's antihyperalgesic effect, in a sex-specific pattern.
Fifteen sessions of inhibitory repetitive transcranial magnetic stimulation (rTMS) treatment at 1 Hz frequency will be applied to the contralesional primary motor cortex (hand region). The application will be performed with Neurosoft-Neuro MS / D device. 120% of the resting motor threshold will be used in the stimulation. One session of stimulation will last for a total of 30 minutes and a total of 1800 pulses in the form of 1 Hz stimulation.
The literature study was conducted by using the Web of Science (WoS) database, employing bibliometric analysis to examine all papers released from 1980 to 2020. The search was performed using the terms "sepsis, septicemia, septic shock" specifically within the titles of the publications. The findings of the literature research revealed a total of 51,725 articles. Out of the total number of publications, 26,896 articles were identified, accounting for 51.9% of the total. The bibliometric study revealed that the United States had the largest number of papers (8693), followed by China (2807), Germany (2299), France (1606), and the United Kingdom (1932). The writers that exhibited the most prolific output in terms of article production on the topic of sepsis were Vincent, with a total of 217 articles, followed by Wang P with 154 articles, and Chaudry IH with 126 articles. The University of Pittsburgh, Brown University, and the University of Michigan were identified as the most productive universities, in that order. The findings from the prediction model revealed that the projected number of articles to be published in 2021 is estimated to be 2086, while the projected number for 2030 is estimated to be 2637. The literature has predominantly focused on disease markers and diagnostic methods, severity and effects of the disease, immunity and inflammation, effects of the disease in neonates and the neonatal period, and treatment and care. According to trend analysis results, recent focus in sepsis research includes a broad spectrum of investigations such as mortality rates, prognostic determinants, diagnostic methods, biomarkers, epidemiological insights, critical care strategies, infections, treatment outcomes, emergency department scenarios, pediatric assessments, and antibiotic interventions.
Eligible subjects will participate in one of the 4 cohorts (3,4,5,6). In each cohort, 2 subjects will be randomized to receive a once-daily oral dose of placebo for 14 days. After the safety data of cohort 3-6 is available, 6 eligible subjects will be randomized to receive once daily oral dose of placebo for 14 days in expansion cohort.
Tramadol hydrochloride tablets should not be used in pregnant women prior to or during labor unless the potential benefits outweigh the risks. Safe use in pregnancy has not been established. Chronic use during pregnancy may lead to physical dependence and post-partum withdrawal symptoms in the newborn (see DRUG ABUSE AND DEPENDENCE). Tramadol has been shown to cross the placenta. The mean ratio of serum tramadol in the umbilical veins compared to maternal veins was 0.83 for 40 women given tramadol during labor.

The effect of tramadol hydrochloride, if any, on the later growth, development, and functional maturation of the child is unknown.