anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a theory for investigating causes of the vertigo, or a breakthrough technique for the diagnosis and treatment of the vertigo and other higher-order neurological dysfunctions.  <P>SOLUTION: In diagnosing symptoms of the vertigo, this method includes (a) a process for at least performing an MR examination and observing three points, the rim of diseases of the white matter pathology, the macular type and the cap, (b) a process for comparing and analyzing the result based on the observation process with a control group, and (c) a process for reading a change in the cerebral water content based on the result of the analysis process. Virus should be considered as an essential and ultimate cause of the vertigo and it is required to find the virus as the ultimate cause of the symptom of the vertigo. To find a specific antibody of the virus is the most quick solution for suppressing the symptom of the vertigo. This analysis is similar to the neurological dysfunctions other than the vertigo.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Active TVS will be performed by use of a Tragus stimulator device with electrodes attached to the tragus of the ear. Stimulator will be applied continuously for 1 hour.
NEW MATERIAL:A monosaccharide derivative shown by the formula I (R is 12-24C aliphatic hydrocarbon group). EXAMPLE:1-O-Methyl branched isostearyl mannofuranoside. USE:A cosmetic, emulsifying agent, oiling agent of self emulsifiable type, wetting agent, and thickening agent. Having strong emulsifying ability, and low skin irritation. PREPARATION:For example, mannose is treated with a carbonyl compound to give a compound shown by the formula II (R1 and R2 are H, lower alkyl, aryl, etc.; X is halogen), which is etherified by the use of a phase transfer catalyst to give a compound shown by the formula III, which is hydrolyzed in the presence of an acid catalyst.
The invention provides new application of stilbene glucoside to the preparation of skin ageing-resistant medicaments. The stilbene glucoside has the effect of clearing oxygen radicals, can also repair cells damaged because of the accumulation of the oxygen radicals in an ageing process, and overcomes the detects that a skin ageing-resistant medicament has one effect and cures the symptoms but not the disease. The stilbene glucoside can be applied to the preparation of the skin ageing-resistant medicaments. The stilbene glucoside and pharmaceutically acceptable salts, esters or sugars and excipients thereof and the like are applied to the preparation of the medicaments for preventing or treating skin ageing state. The stilbene glucoside and the pharmaceutically acceptable salts, esters or sugars and excipients thereof and the like can be prepared into pharmaceutically acceptable orally taken and externally used preparations and formulations, such as tablets, capsules, liniments, medicinal extracts, coating agents, emulsions, nanoparticle emulsions and the like. The stilbene glucoside has wide application prospect in aspects of medical healthcare and the like.
A Chinese traditional medicine prescription used for constipation and preparation method of the invention relates to the technical field of Chinese traditional medicines. The prescription comprises snakegourd seed of 10 to 60g, yam of 10 to 60g, brazi pulp of 20 to 40g, polygonum of 20 to 50g, cistanche salsa of 10 to 40g, mulberry leaf of 20 to 50g, notopterygium root of 20 to 40g, liquorice of 20 to 50g, rapeseed of 10 to 40g, dried spinach of 20 to 60g and lard of 20 to 60g. The method is using the prescription as raw materials for mixing and crashing 100 to 300 items to obtain Chinese traditional medicine powder. Honey is added with half weight of the powder to the Chinese traditional medicine powder, and then Chinese traditional medicine powder honey ointment is obtained, and the Chinese traditional medicine powder honey ointment is prepared into a Chinese traditional medicine honey pill product with 9g for each pill. The Chinese traditional medicine powder is added with water to obtain Chinese medicine powder water ointment, and the Chinese traditional medicine powder water ointment is made into a Chinese medicine powder pigment half-finished product to be dried, then Chinese traditional medicine water-paste pill finished product with 4.5g for each pill is obtained. The invention is used for aiming at people with constipation. The people with constipation choose one of Chinese traditional medicine honey pill and Chinese traditional medicine water-paste pill to take one pill before breakfast, lunch and supper every day. The invention is of good healing effect, short time, small dose and low cost.
Postpartum patients with lumbopelvic pain will receive two sessions per week for a period of 4 weeks of a novel digital therapeutic that combines virtual embodiment with graded motor imagery to deliver functional rehabilitation exercises using an off-the-shelf virtual reality system. The core stability exercises included Bridging, Pelvic rotation, Abdominal Tuck in, Knee to chest and Squatting. Pre and post measurement will be taken before and after the session.
Coronaviruses being capable of spreading through droplet contamination have raised significant concerns regarding high-capacity public rail transport, such as the metro. Within a rapidly moving railcar cabin, the internal airflow lags behind the bulkhead, generating internally induced airflow that accelerates droplet dispersion within a non-inertial reference system. This study investigates the impact of acceleration on the diffusion of cough droplets of varying sizes using computational fluid dynamics. The modified k-ε equation in ANSYS® Fluent was utilized to simulate droplet diffusion under different body orientations by adjusting the inertial force correction source term. Results indicate that droplets in the middle size range (50-175 μm) are primarily influenced by inertial forces, whereas smaller droplets (3.5-20 μm) are predominantly controlled by air drag forces. Regardless of facial orientation, the outlet of high-capacity public rail transport poses the highest risk of infection.
FIELD: cosmetics. SUBSTANCE: the present innovation deals with cosmetic preparation leading to unsticky systems in compositions for hair styling, increasing shock- resistance of nail varnishes and improving resistance in compositions for facial, body and skin make-up, such as nails, eyelashes, eyebrows, hair, consisting of elastic block-copolymer based upon monomers with ethylene bond including, at least, one hard block at glass transition temperature (T q ) being either higher or equal to 20 C, and, at least, one flexible block at glass transition temperature (T q ) being below 20 C, moreover, the above- mentioned copolymers enable to obtain film of immediate reducibility corresponding to 5-100%. The present innovation, also, refers to cosmetic composition for hair styling, far facial, body and skin make-up, such as nails, eyelashes, eyebrows and hair. This method improves capacity for hair styling and softness in hair lacquers, increases shock-resistance of nail varnishes and improves resistance of make-up compositions by not causing discomfort feeling in person under testing. EFFECT: higher efficiency. 35 cl
Each year \>16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory deficits. Although distinct from delirium, POCD (like delirium) is associated with decreased quality of life, long term cognitive decline, early retirement, increased mortality, and a possible increased risk for developing dementia such as Alzheimer's disease. Understanding the etiology of POCD will likely help promote strategies to treat and/or prevent it. A dominant theory holds that brain inflammation causes POCD, but little work has directly tested this theory in humans. The preliminary data of this team strongly suggest that there is significant postoperative neuro-inflammation in older adults who develop POCD. In this K76 award, the investigators will prospectively obtain pre- and post-operative cognitive testing, fMRI imaging and CSF samples in 200 surgical patients over age 65. This will allow the investigators to evaluate the role of specific neuro-inflammatory processes in POCD and its underlying brain connectivity changes.
Chronic myeloid leukaemia (CML) is a haematological malignancy characterized by the constitutive tyrosine kinase activity of the BCR-ABL1 fusion protein. Flumatinib, a second-generation tyrosine kinase inhibitor, has exhibited superior clinical efficacy compared to its precursor, imatinib. However, with increased clinical use, resistance to flumatinib has emerged as a significant challenge. To investigate the mechanisms of flumatinib resistance in CML, we induced the human CML cell line K562 using a flumatinib concentration gradient method in vitro, successfully establishing a flumatinib-resistant K562/FLM cell line. This cell line exhibited cross-resistance to imatinib and doxorubicin, but remained sensitive to the antiparasitic agent ivermectin, which possesses antitumoural effects. Through cellular experimentation, we explored the resistance mechanisms, which indicated that K562/FLM cells evade flumatinib cytotoxicity by enhancing autophagy, increasing the expression of membrane transport proteins, particularly P-glycoprotein, ABCC1 and ABCC4, as well as enhancing phosphorylation of p-EGFR, p-ERK and p-STAT3 proteins. Moreover, it was found that ivermectin effectively suppressed the expression of autophagy and transport proteins in K562/FLM cells, reduced the activity of the aforementioned phosphoproteins, and promoted apoptotic cell death. Collectively, the increased autophagy, higher expression of drug-efflux proteins and hyperactivation of the EGFR/ERK/STAT3 signalling pathway were identified as pivotal elements promoting resistance to flumatinib. The significant effects of ivermectin might offer a novel therapeutic strategy to overcome flumatinib resistance and optimize the treatment outcomes of CML.
INTRODUCTION: Magnetic sphincter augmentation (MSA) is a novel surgical technique investigated at many clinical institutes worldwide. In 2012, it received approval for treating Gastroesophageal reflux disease (GERD) because of its superior benefits compared to drug therapies. This study aimed to explore the safety and efficacy of MSA compared with Laparoscopic Nissen fundoplication (LNF) for GERD treatment.
METHODS: A retrospective analysis was conducted on 40 patients who received preoperative matching features of MSA and LNF. The surgical details and one-year postoperative outcomes were analyzed and reported.
RESULTS: Significant improvement in GERD symptoms was observed in both MSA and LNF patients over the one-year surgical follow-up. Dysphagia was a common postoperative complication observed in both procedures, but no cases required endoscopic dilation. MSA had a significantly shorter operative time compared to LNF (112 vs.175 min, P < 0.001), with faster postoperative dietary recovery [1(0.5,1.5) vs. 3(1.63,5.38) month(s), P < 0.001] and more preservation of hiccup ability (87.5% vs. 45.83%, P = 0.01). No significant disparities were observed between the two groups regarding hospital duration, recovery of physical strength, and upper gastrointestinal complaints.
CONCLUSION: In conclusion, both LNF and MSA are safe and successful surgical therapies for GERD. The benefits of MSA include reduced surgical time, quicker nutritional recovery following surgery, and preservation of hiccup capacity. However, with both surgeries, postoperative dysphagia is a prevalent problem that emphasizes the significance of improving preoperative communication. When selecting between two surgical techniques, it is crucial to consider the postoperative symptoms associated with each procedure.
The study was a prospective randomized trial with a control group (standard care group) and an intervention group, using a repeated measures design. Forty-eight pregnant participants with pregnancy-related LBPP were included in the control group and 48 pregnant participants with pregnancy-related LBPP were included in the intervention (exercise) group.
After local anesthesia, the surgical procedure performed was the trapezoidal-type of CAF (de Sanctis \& Zucchelli, 2007). After the flap was raised, a sterile rubber dam was placed to isolate the operative field and the non-carious cervical lesion restoration was performed with a nanocomposite resin (Filtek Supreme - 3M ESPE - St. Paul, MN, USA), following the manufacturer's instructions. Afterward, a thin and small connective tissue graft that was sutured over the restoration surface. Then, the flap was coronally positioned and sutured to completely cover the graft.
To be taken once daily dosing of 1 tablet in the morning with 250 mL of water. The tablets should not be chewed, but swallowed whole.
The cohort includes patients with acute stroke who underwent CTP, multi-delay ASL, DWI, CTA or TOF-MRA scanning.All patients will be examined within 24 hours of onset. CBF, CBV, MTT and Tmax cerebral blood flow parameter images of CTP will be obtained. CBF, CBV and ATT cerebral blood flow parameter images in multi-delay ASL will be obtained by the quantitative evaluation system. The volume of reversible ischemic tissue will be calculate according to CTP and multi-delay ASL respectively.
The invention discloses a tetrahedral framework nucleic acid targeting RAGE, which is tetrahedral framework nucleic acid loaded with siRNA; the sequence of the siRNA is shown as SEQ ID NO. 5-6. According to the invention, specific siRNA is carried on specific TDNs, so that the expression of RAGE is effectively and continuously regulated, the NF- κB pathway is blocked to inhibit the expression of macrophage inflammatory factor, and the systemic anti-inflammatory and antioxidant functions are exerted. In addition, the focal death state of macrophages can be regulated and controlled through NLRP3/Caspase-1 axis, the steady state of microenvironment is maintained, and the diffusion of cell death signals is inhibited, so that the prevention and treatment of diabetes complications and diseases related to advanced glycosylation end products are realized. In vivo experiments also prove that the invention has therapeutic effect on the systemic pathological tissue injury of diabetic mice. The nucleic acid nano-drug has practical popularization and application values.
The study solution used in the active arm will comprise 20 mL of liposomal bupivacaine (266 mg) admixed with 40 mL of 0.25% bupivacaine HCl. The solution will be administered as bilateral parasternal blocks (40 mL) and bilateral epigastric rectus sheath blocks (20 mL).
Participants who are randomized to this arm will receive ESP during ED care and receive a text-based support program for 4 weeks after discharge, with up to 2 messages per day. The text-based program includes a microrandomized trial (MRT), where participants are randomized twice daily to receive or not receive a message.
Patients in this group will receive the intraoral and extraoral stimulations provided by the PIOMI protocol. These stimulations will last 5 minutes and will be performed once a day for 7 consecutive days for each patient.
Historical group will be a continuous group of Hispanic patients with genotype 1 who were naive to treatment and completed or initiated 48 weeks of pegylated interferon and ribavirin. Patients, who discontinued the treatment due to side effects, adherence issues, or treatment failure, will be included and analyzed based on intention to treat analysis. All patients will be stratified according to their SVR, relapse and no response rate. RVR, EVR, and ETR will be also collated and compared to the study group.
Regular CLABSI preventive protocol. Regular preventive CVL dressings (Chlorhexidine \>2mo).
Participants assigned to the cabotegravir group will initially take a 30mg oral tablet of cabotegravir daily for a four-week period. Following this initial phase, they will receive 13 intramuscular injections of 600mg (3mL) long-acting injectable cabotegravir (CAB-LA) administered every two months after an initial loading dose given one month after the last oral tablet.
BACKGROUND: This study aimed to assess the construct validity and reliability of the Iranian version of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) among the elderly population.
METHOD: A cohort of 230 elderly individuals who tested positive for Covid-19 via PCR were administered a health and demographic information questionnaire along with the C19-YRS. Both exploratory and confirmatory factor analyses were conducted, and Cronbach's alpha was calculated.
RESULTS: Findings from the exploratory and confirmatory factor analyses of the C19-YRS revealed alterations compared to the original version, resulting in an adapted version with three factors achieved by redistributing the questions. These factors accounted for 57.46% of the total variance. Despite a relatively lower factor loading in the 6th question, it was retained due to its significance among the elderly. The Cronbach's alpha for the C19-YRS subscales ranged from 0.730 to 0.890, indicating acceptable reliability.
CONCLUSION: The validation results indicated a well-adjusted factor structure and internal consistency, affirming the utility of this tool among the elderly population. Consequently, the C19-YRS in Iran can serve as a valuable resource in healthcare settings, aiding in the assessment of chronic complications arising from Covid-19 in the elderly. It can be utilized as an initial screening or triage test and to evaluate the effectiveness of interventions.
A physician order entry system and method provides cross-checking of prescribed medications against one or more databases to determine the propriety of administering a prescribed medication to a patient. The system allows entry of a prescription of medication. Once a prescription is entered for a patient, the system checks patient information and/or pharmaceutical information to determine whether the prescribed medication is appropriate. If appropriate, the prescription is forwarded to a pharmacy and filled. The medication is then delivered to the patient for administration. If it is determined that the prescription is inappropriate, a health care professional, such as for example the tending physician or pharmacist is notified of the concern.
The method for the complex treatment of the cervical cancer stage IB comprises cryodestruction and the surgery. The extended panhysterectomy after Wertheim is performed. The neoadjuvant lymphotropic polychemotherapy supplemented with Laferon is performed. Cryodestruction is performed 60 minutes before the surgery. The lymphotropic polychemotherapy is performed according to the following scheme: Methotrexat, single dose of 20-25 mg, total dose of 60-75 mg; Cyclophosphamide, single dose of 550-600mg, total dose of 1650-1800 mg; 5-fluorouracil, single dose of 450-500 mg, total dose of 1350-1500 mg, all the drugs are administered lymphotropically. In addition, Laferon is injected intramuscularlyat a dose of 3 million IU diluted in 5 mL of the distilled water for 10 days, within the time from 17 to 20 hours.
PURPOSE: To carry out the large-scale artificial culture of fruit body of Cordyceps sinensis Sacc. which is equivalent to natural fruit body by culturing Cordyceps sinensis Sacc. in sterilized dried chrysalis to form a mycelium, culturing the mycelium in soil and germinating fruit body thereof on the soil surface. CONSTITUTION: This method for culturing Cordyceps militaris comprises using dried chrysalis (preferably dried silkworm chrysalis) as a culturing substrate, sterilizing the culturing substrate by a method for adding city water in an amount of 100ml based on 100g culturing substrate to the culturing substrate, passing steam through the substrate at 120 deg.C for 20min, then inoculating the sterilized culturing substrate with Cordyceps sinensis Sacc. (preferably Cordyceps militaris) and culturing Cordyceps sinensis Sacc. to form a mycelium, successively embedding the mycelium into soil, preferably vermiculite-like soil, culturing the mycelium so that the fruit body germinates on the soil surface.  Furthermore, culture of Cordyceps sinensis Sacc. in culturing substrate is at first carried out under dark conditions at 20 deg.C for 30 days and then, after the mycelium is formed over whole culture substrate, the culture is preferably carried out at 400-600 lux for 30-50 days until the mycelium exhibits red color tone.
Participants guided through a 15-20 minute defined risk assessment by a trained paramedic. Risk factors assessed were those related to cardiovascular and diabetes risk (blood pressure, diabetes-risk status, lifestyle factors), and potential for falls. Based on these, the paramedic provided education and developed an individualized action plan directing participants to use available community resources to assist them in addressing their risk factors. They were advised to return to CHAP-EMS sessions regularly for BP monitoring and follow-up. Each participant's information was faxed to his/her family physician once a month.
Hepatic fibrosis is a common disease with high morbidity and mortality rates. The complex and poorly understood mechanisms underlying hepatic fibrosis represent a significant challenge for the development of more effective therapeutic strategies. MKP5 is a potential regulator of multiple fibrotic diseases. However, its precise role and mechanism of action in hepatic fibrosis remains unclear. This study identified a reduction in MKP5 expression in fibrotic liver tissues of mice treated with CCl4 and observed that MKP5 knockout mice exhibited a more pronounced development of hepatic fibrosis. In addition, RNA-seq data indicated activation of protein processing in the endoplasmic reticulum signalling pathway in fibrotic liver tissues of mice lacking MKP5. Mechanistically, MKP5 inhibits the activation of hepatic stellate cells (HSCs) and hepatocyte apoptosis through the regulation of the IRE/XBP1 pathway. Based on these findings, we developed PLGA-MKP5 nanoparticles coated with a mesenchymal stem cell membrane (MSCM). Our results demonstrated that MSCM-PLGA-MKP5 was most effective in attenuating hepatic inflammation and fibrosis in murine models by modulating the IRE/XBP1 axis. This study contributes to the current understanding of the pathogenesis of hepatic fibrosis, suggesting that the targeted delivery of MKP5 via a nano-delivery system may represent a promising therapeutic approach to treat hepatic fibrosis.
The invention relates to bovine bone marrow healthcare tea for pulmonary tuberculosis. The healthcare tea is prepared by respectively grinding 31 parts of bovine bone marrow, 16 parts of dried human placenta, 15 parts of pseudostellaria root, 18 parts of lily and 20 parts of pilose asiabell root into powder, mixing the powder, stirring, and subpackaging into bags. The preparation method of the healthcare tea is simple. Raw materials of the healthcare tea are cheap and abundant. The healthcare tea has functions of tonifying qi and yin, nourishing yin and purging fire. Frequent drinking of the healthcare tea can boost body immunity, maintain health, and prevent and treat pulmonary tuberculosis for people.