anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a promoter consisting of an essence of shellfish, excellent in absorption-promoting effect for minerals represented by calcium and high in safety, continuously administrable over a long period, thus useful as a medicine. SOLUTION: This promoter consists of an essence of shellfish (pref. Perna canaliculus). The mineral is pref. calcium as object of absorption promotion. This promoter is obtained, pref. by the following process: a dried flesh of Perna canaliculus is ground, and 20l of n-hexane is then added to 2kg of the resultant powder to wash the powder; the washing operation is repeated twice, and 20l of chloroform is added to the washed powder which is then reftuxed for 3h under heating; insolubles are removed from the resultant extract followed by conducting a concentration, etc.
Each MitoQ capsule contains 20 mg of mitoquinol mesylate. Dosage: 20 mg orally per day for 3 months.
One empirically supported intervention with a large evidence base for improving adult outcomes in behavioral health-related disorders is Motivational Interviewing (MI). MI is strongly rooted in the client-centered therapy of Rogers (1951). Its relational stance emphasizes the importance of understanding the client's internal frame of reference and displaying unconditional positive regard for the client. Motivational interviewing can thus be defined as a client-centered, directive method of therapy for enhancing intrinsic motivation to change by exploring and resolving ambivalence. MI manifests through specific strategies, such as reflective listening, summarization, shared decision making, and agenda setting.

Adolescent participants exposed to motivational interviewing in conjunction with usual care (diet and exercise program) are expected to endorse greater self-efficacy, report increased engagement in healthy behaviors, demonstrate a decrease in body weight and report improved psychological outcomes. While motivational interviewing has been shown to increase adults' motivation to make healthy behavior changes, few adolescent studies have demonstrated this effect.
The regulating means for the absorption of humidity through human skin, comprises particles (4) with dimensions applied on the layer or substrate, where the dimensions are smaller than the opening diameter of the pores (2), water and/or an organic solvent. The dimensions of the particles are small so that more particles deposit in the pores. The particles deposited in the pores are connected under formation of continuous reticulation having cavities and are contained in a fluid applied on the layer and/or the substrate or are bound by a substance rubbable on the layer and/or the substrate. The regulating means for the absorption of humidity through human skin, comprises particles (4) with dimensions applied on the layer or substrate, where the dimensions are smaller than the opening diameter of the pores (2), water and/or an organic solvent. The dimensions of the particles are small so that more particles deposit in the pores. The particles deposited in the pores are connected under formation of continuous reticulation having cavities and are contained in a fluid applied on the layer and/or the substrate or are bound by a substance rubbable on the layer and/or the substrate in highly viscous manner. The particles are manufactured outside of the liquid and in the liquid dispersed or washed in the liquid, and are hybrid particles comprising inorganic and organic material. An independent claim is included for a procedure for regulating for the absorption of humidity through the skin.
Porous precision-templated scaffolds (PTS) with uniform, interconnected, 40 μm pores have shown favorable healing outcomes and a reduced foreign body reaction (FBR). Macrophage receptor with collagenous structure (MARCO) and toll-like receptors (TLRs) have been identified as key surface receptors in the initial inflammatory phase of wound healing. However, the role of MARCO and TLRs in modulating monocyte and macrophage phenotypes within PTS remains uncharacterized. In this study, we demonstrate a synergetic relationship between MARCO and TLR signaling in cells inhabiting PTS, where induction with TLR3 or TLR4 agonists to 40 μm scaffold-resident cells upregulates the transcription of MARCO. Upon deletion of MARCO, the prohealing phenotype within 40 μm PTS polarizes to a proinflammatory and profibrotic phenotype. Analysis of downstream TLR signaling shows that MARCO is required to attenuate nuclear factor kappa B (NF-κB) inflammation in 40 μm PTS by regulating the transcription of inhibitory NFKB inhibitor alpha (NFKBIA) and interleukin-1 receptor-associated kinase 3 (IRAK-M), primarily through a MyD88-dependent signaling pathway. Investigation of implant outcome in the absence of MARCO demonstrates an increase in collagen deposition within the scaffold and the development of tissue fibrosis. Overall, these results further our understanding of the molecular mechanisms underlying MARCO and TLR signaling within PTS. Impact statement Monocyte and macrophage phenotypes in the foreign body reaction (FBR) are essential for the development of a proinflammatory, prohealing, or profibrotic response to implanted biomaterials. Identification of key surface receptors and signaling mechanisms that give rise to these phenotypes remain to be elucidated. In this study, we report a synergistic relationship between macrophage receptor with collagenous structure (MARCO) and toll-like receptor (TLR) signaling in scaffold-resident cells inhabiting porous precision-templated 40 μm pore scaffolds through a MyD88-dependent pathway that promotes healing. These findings advance our understanding of the FBR and provide further evidence that suggests MARCO, TLRs, and fibrosis may be interconnected.
Ariva (oral dissolvable tobacco product). Dosage: 0.24-0.25 mg nicotine per portion.
PURPOSE:An antitumor agent showing high water-solubility, comprising 5,6-O- benzylidene-L-ascorbic acid or its salt as an active ingredient. CONSTITUTION:An antitumor agent containing 0.1-20wt% 5,6-O-benzylidene-L- ascorbic acid shown by the formula or its salt as an active ingredient in the case of oral or mucosa absorption, and 0.01-10wt% 5,6-benzyl-O-ascorbic acid or its salt in the case of parenteral absorption. The compound shown by the formula as an active ingredient is obtained by reacting L-ascorbic acid with alpha,alpha- dimethoxytoluene in dimethyl sulfoxide, etc. in the presence of an acid catalyst (e.g., p-toluenesulfonic acid, etc.) under heating. The antitumor agent can be administered orally or parenterally, and as dosage form, capsule, tablet, fine granule, powder, injection, ophthalmic solution, suppository, etc. may be cited. A dose is 500-1,000g/day/person.
Intercellular communication, an essential biological process in multicellular organisms, is mediated by direct cell-to-cell contact and cell secretary molecules. Emerging evidence identifies a third mechanism of intercellular communication- the release of extracellular vesicles (EVs). EVs are membrane-enclosed nanosized bodies, released from cells into the extracellular environment, often found in all biofluids. The growing body of research indicates that EVs carry bioactive molecules in the form of proteins, DNA, RNAs, microRNAs (miRNAs), lipids, metabolites, etc., and upon transferring them, alter the phenotypes of the target recipient cells. Interestingly, the abundance of EVs is found to be significantly higher in different diseased conditions, most importantly cancer. In the past few decades, numerous studies have identified EV miRNAs as an important contributor in the pathogenesis of different types of cancer. However, the underlying mechanism behind EV miRNA-associated cancer progression and how it could be used as a targeted therapy remain ill-defined. The present review highlights how EV miRNAs influence essential processes in cancer, such as growth, proliferation, metastasis, angiogenesis, apoptosis, stemness, immune evasion, resistance to therapy, etc. A special emphasis has been given to the potential role of EV miRNAs as cancer biomarkers. The final section of the review delineates the ongoing clinical trials on the role of miRNAs in the progression of different types of cancer. Targeting EV miRNAs could be a potential therapeutic means in the treatment of different forms of cancer alongside conventional therapeutic approaches.
Participants will be asked to attend 45 minutes of DSMES and 45 min of TCE twice a week for 6 weeks. All classes will be recorded and available online and can viewed at a time when it is most convenient to accommodate working adults.
OBJECTIVES: Assessing listening difficulties and associated complaints can be challenging. Often, measures of peripheral auditory functions are within normal ranges, making clinicians feel unsure about proper management strategies. The range and nature of observed or experienced difficulties might be better captured using a qualitative measure. The Evaluation of Children's Listening and Processing Skills (ECLiPS) questionnaire was designed to broadly profile the auditory and cognitive problems often present in children with listening difficulties. This 38-item questionnaire was initially standardized in British children aged 6 to 11 years, was subsequently modified for use with North-American children, and was recently translated into Flemish-Dutch. This study aimed to compare typical scores of the Flemish version with the UK and US versions, and to evaluate and compare its psychometric quality based on Rasch analysis.
DESIGN: We selected 112 Flemish children aged 6 to 11 years with verified normal hearing and typical development, and asked two caregivers of every child to fill out the ECLiPS. Data from two comparator samples were analyzed, including responses for 71 North-American children and 650 British children. Typical values for ECLiPS factors and aggregates were determined as a function of age and gender, and meaningful differences across samples were analyzed. Rasch analyses were performed to evaluate whether ECLiPS response categories work as intended, and whether item scores fit a linear equal interval measurement scale that works the same way for everyone. Item and person metrics were derived, including separation and reliability indices. We investigated whether items function similarly across linguistically and culturally different samples.
RESULTS: ECLiPS scores were relatively invariant to age. Girls obtained higher scores compared with boys, mainly for items related to memory and attention, and pragmatic and social skills. Across ECLiPS versions, the most pronounced differences were found for items probing social skills. With respect to its psychometric quality, ECLiPS response categories work as intended, and ECLiPS items were found to fit the Rasch measurement scale. Cultural differences in responses were noted for some items, belonging to different factors. Item separation and reliability indices generally pointed toward sufficient variation in item difficulty. In general, person separation (and reliability) metrics, quantifying the instrument's ability to distinguish between poor and strong performers (in a reproducible manner), were low. This is expected from samples of typically developing children with homogeneous and high levels of listening ability.
CONCLUSIONS: Across the languages assessed here, the ECLiPS caregiver questionnaire was verified to be a psychometrically valid qualitative measure to assess listening and processing skills, which can be used to support the assessment and management of elementary school children referred with LiD.
The invention is a method for the treatment of cancer comprising interactive imaging techniques to optimize the placement of radioactive seeds in a portion of the body containing cancer. The method comprises the computer assisted development of a seed placement plan based on images obtained on a pre-operative day. Seeds are placed into the region of interest in the body, typically the prostate, using an ultrasound guided method. The seeds are imaged using computed tomography (CT) to assess the dose distribution. A second plan, or miniplan, is developed based on information obtained in the CT scan. Additional ultrasound-guided seeds are placed at the same procedure based on the miniplan to optimize the final dose coverage.
Neurorehabilitation training for the upper limb using AOT consists of watching videos related to every day actions. The subjects will be asked to reproduce, as accurately as possible, the actions proposed by the system, that will record their execution. In order to keep high motivation and participation in activities, simple games of skill will also be created that will involve the patient on both the motor and cognitive side. The training program includes 250 videos of every day transitive and intransitive actions: 20 consecutive sessions of 1 hour, five times a week over four weeks.
The study consists of two parts: Part 1 with Part 1a (Assessment of Immune Variation) and Part 1b (Assay Standardization), and Part 2 (Immune Monitoring Study). The study was terminated early with 12 participants enrolled only in Part 1a and Part 1b. Part 2 of the study involved randomization after 8 doses of HSSPC-96. After the 8 doses of HSSPC-96 administered in Part 2, the participants were to be randomized to the treatment extension arm or the placebo extension arm. There were no participants enrolled in Part 2 since the study was terminated early. Therefore, no randomization occurred in the conduct of this study and only a single arm was enrolled.
INTRODUCTION: The current literature suggests that the frequency and complexity of public health emergencies are rising and this trend will likely continue. From 2000 to 2023, seven events have been declared as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO). Organisational models such as the Incident Management System, Incident Response System and Incident Command System or country-specific models are essential in managing PHEIC.The review aims to achieve four key objectives. First, identify and describe the organisational models used in the South-East Asia Region (SEAR) nations defined by WHO as Bangladesh, Bhutan, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand, Timor-Leste and DPR Korea for managing PHEICs. Second, explore the indicators used to gauge the effectiveness of these models. Third, assess how these indicators impact the overall success of organisational models. Finally, the review will delve into the implementation aspects gaining a deeper understanding of how the organisational models are put into practice to manage PHEICs in the SEAR region.
METHODS AND ANALYSIS: Following Preferred Reporting Items for Systematic review and Meta-Analysis Protocols guidelines, a qualitative evidence synthesis will be conducted. A defined search strategy will be employed to conduct a comprehensive literature search of the following academic databases: PubMed (MEDLINE), Excerpta Medica Database, Cochrane CENTRAL, Cumulative Index to Nursing and Allied Health Literature, WHO Library Database, US Centers for Disease Control and Prevention (CDC), CDC's Morbidity and Mortality Weekly Report and Web of Science; as well as non-academic databases including Google Scholar, Evidence Aid, Epistemonikos, Shodhganga and ResearchGate. This review will employ the SPIDER-D tool for searching qualitative studies. Two reviewers will check the quality of included studies and will be appraised using standard critical appraisal tools. In case of any difference between the two reviewers, a third reviewer will take the decision.
ETHICS AND DISSEMINATION: No ethical approval is required. Results will be published in a peer-reviewed journal and disseminated through a workshop for stakeholders and policymakers.
PROSPERO REGISTRATION NUMBER: CRD42023394418.
PROBLEM TO BE SOLVED: To provide an X-ray CT system by which the X-ray dosage of a subject can be reduced, and the working efficiency and the picture quality can be improved by determining proper imaging conditions, and performing the scanning conforming to the imaging conditions. SOLUTION: An X-ray absorptivity map regarding the subject is prepared based on scanning image data which is obtained from a specified direction to the subject P. Then, imaging conditions are determined based on the absorptivity map. Prior to a tomographic imaging, an index indicating the dosage when scanning is performed conforming to the imaging conditions is calculated, and is displayed together with the imaging conditions. Also, when the imaging conditions are updated, the index indicating the dosage is calculated and displayed every time when the updating is performed. The tomographic imaging is performed conforming to the imaging conditions which are finally determined. Thus, the dosage of the subject is reduced, and the tomographic image of a favorable picture quality can be obtained.
Recurrent aphthous stomatitis (RAS) is a common oral lesion with no definitive treatment; current therapies primarily focus on symptom relief. This study aims to address the lack of high-quality clinical research by evaluating the effectiveness of Photobiomodulation Therapy (PBMT) using GaAlAs 808 nm, AlGaInp 660 nm, and GaAs 635 nm lasers for managing aphthous lesions. The study focuses on the lasers' effectiveness in reducing pain, accelerating healing, enhancing patient satisfaction, and preventing recurrence compared to a control group. A randomized controlled clinical study was conducted with 64 RAS patients, divided into four groups: 808 nm laser, 660 nm laser, 635 nm laser, and a placebo. Pain severity, ulcer size, and erythema were evaluated at various time points before, immediately after, and several days post-treatment, while patient satisfaction and recurrence were assessed after one month. All laser groups significantly reduced pain intensity, ulcer size, and erythema, with the 808 nm laser showing the most pronounced effects. Mean pain scores in the laser groups decreased to zero by day 7, whereas the control group had a slower reduction (p < 0.001). Ulcer size was significantly smaller in the 808 nm group on days 3 and 7 (p < 0.05). Erythema was significantly reduced by day 7 (p < 0.05). The 808 nm laser also resulted in the highest patient satisfaction, with no recurrences observed in any group. PBMT is an effective treatment for RAS, and the 808 nm laser was the most effective wavelength used.
ABSTRACT OF THE DISCLOSURE   The invention relates to compositions used for topical adminis-tration of griseofulvin and antibiotics of the lincomycin and erythromycin families.  Various therapeutic methods for treating acne have been attempted including topical antibacterials, e.g. hexachlorophene, and systemic anti-biotics such as tetracycline and clindamycin.  While the systemic antibiotic treatments have been effective, the topical antibacterial treatments have not been effective.  The present invention provides a topical antimicrobial composition comprising compositions containing 0.1 to about 10% by wt. of griseofulvin or an antibiotic from the lincomycin or erythromycin families and about 5 to about 99.9% by wt. of 2-pyrrolidone or an N-alkyl-2-pyrrolidone.
According to one embodiment, a medical image diagnostic apparatus includes an imaging unit, an image generation unit, and a display unit. The imaging unit images a subject injected with blood vessel contrast enhancement particles and diseased tissue contrast enhancement particles. The blood vessel contrast enhancement particles have the first particle size larger than the gap of vascular endothelial cells under the EPR effect. The diseased tissue contrast enhancement particles have the second particle size smaller than the gap. The image generation unit generates a medical image associated with an imaging region of the subject based on output data from the imaging unit. The display unit displays the medical image.
Novel single-chain protease resistant urokinase derivatives are provided. In particular, derivatives are provided wherein the Lys 135 Lys 136  and Arg 156  to Lys 158  sites are rendered less susceptible to proteolytic cleavage are provided by occluding the sites or by covalently modifying them. Preferred covalent modifications are amino acid sequence variants at the sites where proteolysis of urokinase occurs. These are optimally produced by synthesis of single-chain urokinase mutants in recombinant cell culture. The novel urokinase derivatives herein offer the advantage of avoiding the generation of substantial two-chain urokinase, either in vivo or during recombinant cell culture. However, the derivatives continue function to activate plasminogen in initiating blood clot lysis.
The field of infectious diseases saw numerous exciting advances in 2023. Trials of new antibiotics and treatment regimens sought to address rising rates of antimicrobial resistance. Other studies focused on the most appropriate use of currently available treatments, balancing the dual goals of providing effective treatment and impactful antimicrobial stewardship. Improvements in disease prevention were made through trials of both new vaccines and new chemoprophylaxis approaches. Concerning trends this year included increasing rates of invasive group A streptococcal infections, medical tourism-associated cases of fungal meningitis, and the return of locally acquired malaria to the United States. This review covers some of these notable trials and clinical developments in infectious diseases in the past year.
SS-31 is a mitochondria-targeting short peptide. Recent studies have indicated its hepatoprotective effects. In our study, we investigated the impact of SS-31 on LPS-induced autophagy in HepG2 cells. The results obtained from a dual-fluorescence autophagy detection system revealed that SS-31 promotes the formation of autolysosomes and autophagosomes, thereby facilitating autophagic flux to a certain degree. Additionally, both ELISA and qPCR analyses provided further evidence that SS-31 safeguards HepG2 cells against inflammatory responses triggered by LPS through ATG5-dependent autophagy. In summary, our study demonstrates that SS-31 inhibits LPS-stimulated inflammation in HepG2 cells by upregulating ATG5-dependent autophagy.
In Part A, HCV GT1-infected NC participants will take GZR 100 mg + UPR 450 mg + EBR 50 mg q.d. by mouth for 8 weeks.
Methods for producing a mono- or multilayer composite are provided in which one or several layers are applied onto a carrier material by coating, the coated mono- or multilayer composite is dried and rolled up, and the installation is subsequently cleaned. The air circuit in the drying oven is entirely set to fresh air supply, and the drying oven is configured to be cleaned in a controlled manner. All components of the drying oven that come into contact with the product do not have to be removed during cleaning, but can be cleaned-in-place using technology integrated into the drying oven. The drying oven Outer housing is designed so that it can be lifted upwardly. All assembly parts in the drying oven interior are designed to eliminate disassembling for cleaning purposes. Transport rollers within the drying oven are designed as hollow shafts and provided with spraying nozzles.
PURPOSE:To obtain a skin cosmetic of high safety, said cosmetic manifests aesthetic effect such as skin activation, revival and skin color-lightening effect by adding L-carnosin or its salt. CONSTITUTION:The subject skin cosmetic is obtained admixing 0.1 to 15% of L-carnosin or its salt to conventional cosmetic components and additives, for example, oil, an ultra-violet absorber, a surfactant, an antiseptic, a humectant, perfumes, water, alcohol, a thickener, a colorant and other additives in an appropriate proportion in a usual manner. The formulation can be prepared into emulsion, lotion, cream, jelly, pack or the like. L-carnosin has melting point: 250 deg.C, specific rotation: [alpha] =+20.0 deg. (H2O), no taste, no smell and white crystalline powder readily soluble in water. It is obtained by a known method and the use of synthetic L-carnosin which is commercially available is economical and inexpensive.