anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Prevalence of intellectual disability (ID) is currently estimated through parent report on surveys of children. It is difficult to estimate the number of adults living with ID in the United States because no comprehensive survey or surveillance allows for identification. The purpose of this study was to estimate the prevalence and number of adults with ID born between 1980 and 1999 using multiple years of the National Health Interview Survey (NHIS) and Census data.
METHODS: We concatenated the NHIS from 1997-2016 that evaluated parental response about whether a child aged 3-17 years had an ID. Using weighted survey analyses, we estimated the prevalence of ID among individuals across four birth cohorts-(1) 1980-1984, (2) 1985-1989, (3) 1990-1994, and (4) 1995-1999. The number of adults with ID was then extrapolated by applying these prevalence rates to Census population estimates (as of 1 July 2021) of respective birth cohorts.
RESULTS: Weighted prevalence of ID varied by birth cohort, sex, race and ethnicity, and US Census Bureau regions. The overall prevalence rate was 1.066 [95% confidence interval (CI): 0.831-1.302] for adults born between 1980 and 1984, 0.772 (CI: 0.654-0.891) for adults born between 1985 and 1989, 0.774 (0.675-0.874) for adults born between 1990 and 1994, and 1.069 (CI: 0.898-1.240) for adults born between 1995 and 1999. Overall, we estimate that 818 564 adults with ID who were approximately 21-41 years were living in the United States as of 2021.
CONCLUSIONS: This study provides researchers examining adult health outcomes with an estimated denominator of young and middle-aged adults living with ID in the United States. Policymakers can use this information to support justification for resource and service needs, and clinicians may benefit from understanding that ID is a lifelong developmental condition often with additional physical, emotional and developmental needs requiring tailored care.
This group will receive a Stage-Tailored Manual at baseline. It will also get Full TTM-Tailored Feedback Reports, that is, integrated tailored feedback reports based on assessments of stage of change, decisional balance (pros + cons), temptations and (ten) processes of change at Baseline, 6, and 12 months. Outcomes will be assessed at 24 months.
Participants with R/R follicular lymphoma will receive tazemetostat and mosunetuzumab for approximately 1 year. After approximately 1 year, participants will receive tazemetostat alone.
PURPOSE:To obtain a light screening packaged magerial, capable of inhibiting the photodegradatin of a photodegradable medicine containing the accommodated medicine seen through from the outside, by using a light screening film having a specific condition. CONSTITUTION:A packaged PTP (press through pack) or heat-sealed material which is a light screeening packaged material of a photodegradable medicine is obtained by using a light screening film, e.g. a light screening film corresponding to a concentration of a pigment 3-5 times that in ''VSS1101 UV3 Brown 4-670 '', made of vinyl chloride, having a thickness of 250mum, and manfactured by SUMITOMO BAKELITE KK, transmitting 40% or more rays of wavelengths >=600nm without transmitting rays of wavelengths <=500nm. A dihydropyridine compound, e.g. nifedipine or nicardipine, may be cited as the photodegradable medicine. A vinyl chloride film having a thickness of 200-350mum is used for the PTP packaging, and polyethylene film, cellophane polyethylene laminate film, etc. having a thickness of about 80mum is used for the heat-sealing packaging.
Both arginine and its derivative nitric oxide (NO) have been implicated in the regulation of glucose homeostasis. Arginine is a β cell secretagogue, potentiating glucose stimulated insulin secretion. Further, it has been shown that glucose can stimulate NO production in primary β cells, and NO then enhances insulin secretion.

On the other hand, because the only known fate of citrulline is its conversion to arginine, citrulline supplementation could be a more efficient and safe way to increase intracellular arginine. Compared to enteral arginine, citrulline administration to healthy humans elicited a greater increase in plasma arginine and NO products, suggesting a greater increase in cellular arginine availability for NO synthesis. Therefore dietary citrulline supplementation will result in greater arginine availability and NO synthesis than arginine supplementation per se in KPD patients. In addition, because the consequences of diminished NO production in usual type 2 diabetes includes vascular dysfunction, an overall increase in NO production in response to citrulline supplementation will result in an improvement in vascular function assessed by arterial flow-mediated dilation
Older adults with diabetes on multiple insulin injections are at greater risk of hypoglycemia and its poor outcomes. Use of continuous glucose monitoring (CGM) has shown to improve glycemic control and reduce hypoglycemia in this age group. Despite Medicare coverage for CGM, uptake in this age group is still low. The goal of this study is to facilitate the adoption of continuous glucose monitoring (CGM) in older adults (≥65 years) with diabetes mellitus (DM) on complex insulin regimens, and additionally, to build a framework for sustained CGM use over time using a novel patient-centered model - the REST model. This model will assess Readiness and barriers to CGM initiation and utilization, provide remote Education, and implement a framework for Sustainability of CGM Technology adoption. The study will assess the impact of the REST model and its ability to increase CGM uptake and use in this age group, as well as its effectiveness on improving glycemic metrics. The study will also evaluate the impact of the REST model on economic and health-related quality-of-life measures.
1462012 Amorphous silica MONSANTO CO 20 Jan 1975 [21 Jan 1974 (2)] 2329/75 Heading C1A [Also in Division A5] Synthetic amorphous silica having a refractive index from 1À410 to 1À440 is prepared by reacting particulate hydrous alkali metal silicate containing 10-25 wt. per cent of water with aqueous acidic solution containing hydrogen ions in excess of the quantity required to replace essentially all the alkali metal ions by hydrogen ions, allowing sufficient time for the exchange, and recovering and drying the silica particles produced. The particle diameter as initially produced varies from 1-300 Á and may be ground to average particle diameter of 1-30 Á. The alkali metal silicates generally have an SiO 2 /M 2 O ratio of from 1À60 to 3À75. The amorphous particulate silica may be used as a polishing agent together with a liquid phase of the same R.I. comprising water and a humectant (e.g. sorbitol, glycerine) to form a translucent dental cream, or it may be used as part of the polishing agent in opaque dental creams which may contain other polishing agents such as dicalcium phosphate, flavourings, fluoride ions, and suitable sudsing agents.
BACKGROUND: People with intellectual disabilities often need assistance of some kind in their everyday life. Support needs can increase the risk of their victimization at the hands of professional and family caregivers. This paper explores the differences in caregiver victimization between participants living in residential care settings and those who are not.
METHOD: A sample of 260 adults (59.2 % men) with an intellectual disability diagnosis were assessed using an adaptation of the Juvenile Victimization Questionnaire comparing prevalence, sum and variety scores.
RESULTS: More than half of the sample (59.2 %) experienced some form of caregiver victimization throughout their lifetime, with physical abuse, verbal abuse, and neglect being the most frequently reported forms. Participants in residential care settings experienced significantly more caregiver victimization incidents and a broader range of victimization forms than their counterparts outside residential care. Significant differences were found based on the individuals' place of residence and gender. Details are provided on the last victimization incident, the perpetrator, the psychological and physical consequences of the victimization, and the reporting rates.
CONCLUSIONS: This study outlines high rates of lifetime caregiver victimization, with those who live in residential care settings at particular risk. Further research is needed to gain a deeper understanding of the nuances of caregiver victimization and to prevent abuse in caregiving contexts.
PURPOSE: Genomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations.
MATERIALS AND METHODS: RNA sequencing was performed on 647 previously untreated stage I-III estrogen receptor-positive/human epidermal growth factor receptor 2-negative tumors in the Carolina Breast Cancer Study, which oversampled Black and younger women (age <50 years at diagnosis), using research versions of two common RNA-based prognostic assays: ROR-PR and the 21-gene recurrence score (RSR). Relative frequency differences and 95% CIs were estimated for associations with race and age, and hazards of 5-year local or distant recurrence were modeled with Cox regression. Proliferation and estrogen module scores from each assay, representing broad activity of genes in those pathways, were examined to guide interpretation of differences between tests.
RESULTS: Among both younger and older individuals, Black women had higher frequency of intermediate and high ROR-PR scores than non-Black women. Race was not significantly associated with RSR in either age group. High (hazard ratio [HR], 4.67 [95% CI, 1.73 to 12.70]) and intermediate (HR, 2.12 [95% CI, 0.98 to 4.62]) ROR-PR scores were associated with greater risk of recurrence, but RSR did not predict recurrence. RSR emphasized estrogen over proliferation modules, whereas ROR-PR emphasized proliferation. Higher proliferation scores were associated with younger age and Black race in both assays. Modifications to the RSR algorithm that increased emphasis on proliferation improved prognostication in this diverse population.
CONCLUSION: ROR-PR and the 21-gene RSR differentially emphasize estrogen-related and proliferative biology. The emphasis of 21-gene RS on estrogen-related biology and lower endocrine therapy initiation among Black women may contribute to poorer prognostic ability in heterogeneously treated populations.
Acetaminophen Injection is supplied in a single-dose, ready-to-use flexible plastic infusion bag in a foil laminate overwrap containing 1,000 mg acetaminophen per 100 mL (10 mg/mL). The infusion bags and ports are manufactured with materials that do not contain latex. Carton of 10 bags, NDC 0143-9386-10.

Acetaminophen Injection is a sterile, clear, colorless to faint yellow, non-pyrogenic, isotonic formulation of acetaminophen intended for intravenous infusion.

Acetaminophen Injection should be stored at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature]. For single-dose only. It is recommended that infusion bags be kept in the overwrap until ready to use. Once removed from the overwrap, unused Acetaminophen Injection has stability for 24 hours. The product must be used within 4 hours after the bags are pierced. However, immediate use of the pierced bags is recommended. Do not refrigerate or freeze.
Group 1 receives all three interventions in the order of assistance, then sham (slack springs), then anti-assistance. Each intervention corresponds to different settings on the device.
PURPOSE: Meconium-stained amniotic fluid (MSAF) often signifies colonization of the amniotic sac by microorganisms. This study investigated additional adverse obstetric outcomes associated with MSAF in deliveries complicated by maternal intrapartum fever (IF).
METHODS: This retrospective study included all singleton pregnancies from 2014 to 2020, with intrapartum maternal fever ≥ 38 °C during a trial of labor. In accordance with departmental protocol, all patients received intravenous antibiotic therapy consisting of ampicillin and gentamicin in the absence of allergies to these medications. Subsequent antibiotic therapy was adjusted based on the culture results. Antibiotic treatment was discontinued postpartum after 48 h without fever. Swab cultures were obtained immediately postpartum from both the maternal and fetal sides of the placenta. Maternal and fetal outcomes, along with positive placental cultures, were compared between participants with MSAF&IF and those with clear amniotic fluid &IF (control group).
RESULTS: In comparison to the control group (n = 1089), the MSAF&IF group (n = 264) exhibited significantly higher rates of cesarean delivery (CD) (p = 0.001), CD due to non-reassuring fetal heart rate (p = 0.001), and cord pH ≤ 7.1 (p = 0.004). Positive swab cultures from the placental maternal and fetal sides were more prevalent among the MSAF&IF group (23.1% vs. 17.6%, p = 0.041 and 29.2% vs. 22.9%, p = 0.032, respectively). Placental cultures yielding gastrointestinal pathogens and extended spectrum beta-lactamase were notably more common in the MSAF&IF group compared to controls (p = 0.023). However, there was no significant difference between groups regarding the rate of group B streptococcus positive placental cultures.
CONCLUSIONS: Women experiencing IF and MSAF during labor face an elevated risk of CD compared to those with IF alone. The presence of MSAF heightens the risk of positive placental cultures, particularly with gastrointestinal and extended spectrum beta-lactamase pathogens.
PURPOSE:To carry out fine pulverization for improving the extraction efficiency and intake efficiency of a medicinal plant, by pulverizing the medicinal plant while cooling the medicinal plant at a specific temperature. CONSTITUTION:A medicinal plant, e.g. medicinal herb, SHIITAKE mushroom or polypore, is pulverized while in contact with a cryogenic refrigerant having <=-100 deg.C boiling point, e.g. liquid air, liquid nitrogen or liquid helium. In the process, moisture contained in the medicinal plant is frozen in a moment, but the hardness of ice formed at the cryogenic temperature is very high to facilitate the fine pulverization thereof. The lumps of the ice, having high hardness, and contained in the frozen medicinal plant exhibit the behavior as a pure elastic body and resonate to the vibration caused by the pulverization impact to crush the cellular membranes of the medicinal plant. Thus, the medicinal plant can be finely pulverized to give <=100 mesh particle size.
A system and associated method that provides a virtual coach to a person during an exercise routine includes a sensor used to sense the level of a physiological parameter of the exerciser, such as heart rate, a processor programmed to compare the sensed physiological parameter to a target level of the physiological parameter, and, depending on the comparison, provide coaching prompts to the exerciser. Coaching prompts include audible and visual prompts. In another feature, a visual image of a virtual coach may be made available for display to the exerciser, and in yet another feature, a video of the virtual coach saying the audio prompt may be displayed. The system allows for selection from a plurality of virtual coaches. The audio and video of virtual coaches are recordings of real people and may be produced or obtained from other sources. In one embodiment, audio, visual, and video of the virtual coach may be downloaded from the Internet.
PURPOSE:To obtain a mutation inhibitor, containing a specific substance obtained by extracting a fruit or seed of Hovenia dulcis Thunb. and purifying the resultant extract and capable of exhibiting excellent mutation inhibitory activity and inhibiting mutagenicity due to a direct mutagen without especially requiring metabolic activation. CONSTITUTION:A mutation inhibitor containing a substance obtained by extracting a fruit or seed of Hovenia dulcis Thunb. and purifying the resultant extract. The aforementioned substance has the following properties. (a) A freeze- dried substance assumes light brown color; (b) soluble in 100% ethanol, 40% ethanol, methanol and DMSO and sparingly soluble in water, ethyl acetate and chloroform; (c) ultraviolet absorption spectrum of a 40% ethanol solution shows the maximum absorption at about 280nm; (d) a 40% ethanol solution assumes dark green to dark purple color with ferric chloride; (e) the retention time is about 17-19 in a chromatogram of the following liquid chromatography. column; (4X300mm), solvent; H3PO4 (0.1M) ; K2PO4 (0.1M):EtOH:EtOAc=50:50:2:5 (volume ratio) and flow velocliy; 5ml/min.
The present invention relates to a composition for antioxidation, skin-whitening, and wrinkle amelioration, containing Paeonia lactiflora Pall., Atractylodes macrocepha-la Koidz, Angelica dahurica root, and Tribulus terrestris L.. The present invention further relates to a functional cosmetic product comprising the same. According to the present invention, antioxidative activity is detected, and melanin synthesis, tyrosinase activity, and an amount of protein expression are inhibited. In addition, the rate of cell increases as well as the content of procollagen secreted into culture liquid. Furthermore, secretion of procollagen which was reduced by ultraviolet-B (UVB) also increases depending on concentration. Therefore, the composition and the functional cosmetic product show effectiveness in antioxidation, whitening, and wrinkle amelioration.
On day 0, patients will receive a fixed dose of 1.0-3.0 x 10\^9 allogeneic UCB-NK cells. Prior to NK cell infusion, patients will receive cyclophosphamide and fludarabine (Cy/Flu) based lymphodepleting chemotherapy. NK cells administration will not be followed by sc IL-2. N=3.
BACKGROUND: Parents of a child with neurological problems such as seizures and epilepsy experience significant mental distress. Little is known about the mental state of parents in such a stressful situation. This study aims to determine the prevalence of self-reported depression, anxiety, sleep disorders, and quality of life in parents of children with epilepsy and first unprovoked seizure.
METHODS: This cross-sectional study was conducted among the parents of children diagnosed with first unprovoked seizure and epilepsy admitted to the Pediatric Neurology Department, Outpatient Unit of İnönü University Medical Faculty Hospital. Participants filled out a questionnaire investigating demographic variables, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and 36- Item Short-Form Health Survey (SF-36).
RESULTS: 113 parents participated in the study. Depression was found in 7%, anxiety in 14%, and sleep quality disorder in 33.3% of parents of children diagnosed with epilepsy on the basis of moderate or higher severity, while depression was found in 8.9%, anxiety in 14.3%, and sleep disorder in 21.4% of parents of children diagnosed with first unprovoked seizure. There was no statistically significant difference between the groups. Mothers were at higher risk for loss of physical function and social functionality. There was a positive correlation between BAI, BDI, and PSQI scores. Quality of life sub-dimension measured by SF-36 was associated with different levels of depression, anxiety, and sleep quality.
CONCLUSION: Addressing parental psychiatric problems by professionals involved in the treatment of children with a history of seizures may have the potential to provide further support for the family and the care of patients.
This invention uses a polyoxyethylene ether segment as the linking group and add biodegradable, non-toxic to the human body with carbohydrate (ex. glucose, xylose, maltose, sugar,...) and siloxane synthesis reaction, through a condensation reaction of a water-insoluble siloxane and hydrophilic glucose. The structures contain both of hydrophilic and hydrophobic properties. Significantly enhance the water-soluble and exhibits excellent characteristics. It had a wider use of industrial applications. In addition, further improve the efficiency of biodegradable. These water-soluble surfactants of carbohydrate modify siloxane are anticipated to have good emulsifying ability, excellent wetting ability and enhance gloss, while both the biodegradable characteristics of the natural environment. It can be widely used in the dyeing and finishing, cosmetics, cleaning supplies, food emulsifying and other related industries. They have good industrial application.
Trajectories refer to the motion paths followed by objects in space. Disease trajectories, which depict the evolution of disease processes over time, are significantly important for assessing diseases, formulating treatment strategies, and predicting prognosis. Critical illness is one of the leading causes of death. With advances in critical care medicine, there is increasing focus on the occurrence and development of critical illnesses. Understanding the development trajectory of critical illness is helpful to promote the early identification, intervention, and treatment of high-risk patients, avoid prolongation of the course of disease, reduce the risk of multiple organ failure, and provide important reference for the development of targeted prevention and intervention strategies, thereby reducing the incidence and mortality of critical illness. In recent years, various trajectory modeling methods have been applied to the study of critical illness. These include, but are not limited to, latent growth curve modeling (LGCM), growth mixture modeling (GMM), group-based trajectory modeling (GBTM), latent transition analysis (LTA), and latent class analysis (LCA). The aim of this article is to review the definition of disease trajectories, the methods used in trajectory modeling, and their applications and future prospects in critical illness research.
Patients receive carboplatin IV over 30 minutes on day -2 of cycle 1 only. Patients also receive pembrolizumab IV over 30 minutes on day 1 of each cycle. Cycles repeat every 6 weeks for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo CT or MRI throughout the trial. Patients also undergo blood sample collection on the trial.
Pulmonary arterial hypertension (PAH) is associated with aberrant pulmonary vascular smooth muscle cell (PASMC) function and vascular remodeling. MiR-30d plays an important role in the pathogenesis of several cardiovascular disorders. However, the function of miR-30d in PAH progression remained unknown. Our study shows that circulating miR-30d level is significantly reduced in the plasma from PAH patients. In miR-30d transgenic (TG) rats, overexpressing miR-30d attenuates monocrotaline (MCT)-induced pulmonary hypertension (PH) and pulmonary vascular remodeling. Increasing miR-30d also inhibits platelet-derived growth factor-bb (PDGF-bb)-induced proliferation and migration of human PASMC. Metadherin (MTDH) and phosphodiesterase 5A (PDE5A) are identified as direct target genes of miR-30d. Meanwhile, nuclear respiratory factor 1 (NRF1) acts as a positive upstream regulator of miR-30d. Using miR-30d knockout (KO) rats treated with sildenafil, a PDE5A inhibitor that is used in clinical PAH therapies, it is further found that suppressing miR-30d partially attenuates the beneficial effect of sildenafil against MCT-induced PH and vascular remodeling. The present study shows a protective effect of miR-30d against PAH and pulmonary vascular remodeling through targeting MTDH and PDE5A and reveals that miR-30d modulates the beneficial effect of sildenafil in treating PAH. MiR-30d should be a prospective target to treat PAH and pulmonary vascular remodeling.