anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE OF REVIEW: The primary aim of this review is to describe and update the pathophysiological and relevant therapeutic strategies for freezing of gait (FoG) in patients with Parkinson's disease (PD).
RECENT FINDINGS: FoG presumably involves dysfunction of multiple cortical and subcortical components, including dopaminergic and nondopaminergic circuits. In this regard, levodopa and physical therapy represent the first-choice therapeutic options for PD patients with FoG. However, the relationship between FoG and levodopa is not fully predictable. For those patients with levodopa-resistant FoG, there is promising but still controversial data on the benefits of bilateral high-frequency transcranial magnetic stimulation and deep brain stimulation on the subthalamic nuclei, substantia nigra pars reticulata, pedunculopontine nucleus, and the Fields of Forel. On the other hand, general exercise, gait training with a treadmill, focus attention on gait training, and conventional physiotherapy have demonstrated moderate to large benefits in FoG.
SUMMARY: FOG requires different treatment strategies. The inclusion of adequate detection and prediction of FoG combined with double-blind, and statistically powered protocols are needed to improve patients' quality of life, the motor and nonmotor symptoms and societal burden associated with FoG.
An absorbable hemostatic composition for use in the control of osseous haemorrhage having a putty-like consistency at room temperature and a tackiness sufficient for it to adhere readily to a bloody bone surface and comprising: (A) between 35% and 80% (by weight, based on the weight of the total composition) of a calcium, magnesium, zinc, aluminium, lithium or barium salt of a C10 to C22 saturated or unsaturated fatty acid and (B) a biocompatible natural or synthetic oil or wax, provided that when the composition comprises between 35 and 45% of the fatty acid salt it further comprises, as an absorption enhancing agent, between 25% and 35% (by weight of the total composition) of a dextran, an ethylene oxide/propylene oxide block copolymer, a polyethylene glycol, a methoxy polyethylene glycol, glycerine or propylene glycol. - (14pp) EPAB- EP-109310 B An absorbable hemostatic composition for use in the control of osseous haemorrhage having a putty-like consistency at room temperature and a tackiness sufficient for it to adhere readily to a bloody bone surface and comprising: (A) between 35% and 80% (by weight, based on the weight of the total composition) of a calcium, magnesium, zinc, aluminium, lithium or barium salt of a C10 to C22 saturated or unsaturated fatty acid and (B) a biocompatible natural or synthetic oil or wax, provided that when the composition comprises between 35 and 45% of the fatty acid salt it further comprises, as an absorption enhancing agent, between 25% and 35% (by weight of the total composition) of a dextran, an ethylene oxide/propylene oxide block copolymer, a polyethylene glycol, a methoxy polyethylene glycol, glycerine or propylene glycol. USAB- USRE32208 E Haemostatic compsn. comprises a physiologically acceptable Ca, Mg, Zn, Al, Li or Ba salt of a 10-22C opt. unsaturated fatty acid (45-80 wt.%), or mixt. of such a salt (35-45 wt.%) and an absorption stimulant (25-35 wt.%) and an easily absorbed carrier such as ethylene oxide/propylene oxide block copolymers, polyethyleneglycols, methoxypolyethyleneglycols, triglycerides and fatty esters. C.f. US4439420.
AGN-210669 non-preserved ophthalmic solution, 0.05%. One drop in both eyes each morning once-daily for 2 weeks.
The invention discloses a traditional Chinese medicine composition for treating cervical spondylosis caused by kidney deficiency and blood stasis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared by taking prepared rehmannia root, tuber fleeceflower root, eucommia bark, pyrola, rhizoma drynariae (scalded), uncaria, kudzu root, pseudo-ginseng and radish seed (fried) as raw materials, can radically treat diseases, achieves the aim of curing, and has better curative effect on cervical spondylosis caused by kidney deficiency and blood stasis. The product has no adverse side effects, and is suitable for popularization and application. In addition, the traditional Chinese medicine composition for treating cervical spondylosis caused by kidney deficiency and blood stasis is mainly prepared by the processes of drying, crushing, extracting, concentrating, vacuum drying, granulating, grading, filling and the like. The process is simple to operate, short in production period and low in cost, and is suitable for industrial mass production. The preparation form is capsule, the eating method is simple, and the carrying is convenient.
Patient will transition from one of four University of Washington (UW) medical centers to one of 14 post-acute skilled nursing facilities randomized to the control arm. Patients will receive the standard discharge process.
The purpose of this study is to validate a revised food frequency questionnaire that is designed to capture vitamin D, calcium and protein intake in a population of elderly men and women with fragility fractures. Protein, calcium and protein intake will be correlated with biochemical measures and bone mineral density measured by DXA.

Eligibility Criteria) Forty-five eligible participants will be recruited from the endocrine referrals for osteoporosis/fracture. They will be men and women, age \>65 years with a fragility fracture (defined as a fracture sustained after a fall from a standing height or less). They will be English speaking. They will need to have the mental capacity to recall events, (MMSE score ³24).11 They will need to have a telephone and the ability to answer questions over a phone. They will not have secondary causes of fragility fracture such as malabsorption (celiac disease, bariatric surgery), liver disease, organ transplant, hyperparathyroidism, multiple myeloma, current cancer diagnosis, or alcoholism. They will not have renal disease requiring dialysis (as the dietary requirement of these patients is quite different from the general elderly population). They will not be on tubefeeds of any kind (although supplemental food such as Ensure is allowed). Interventions and Evaluations) The evaluations will include a history and physical exam, and a mini mental status exam. Two telephone interviews will be conducted \~ 4 weeks apart during which the Block 2014 questionnaire will be given and the revised screener will be given. The order that the questionnaires are given will be randomized. As part of the standard of care workup for osteoporosis, a biochemical workup including 25-hydroxyvitamin D, comprehensive metabolic profile, bone specific alkaline phosphatase (a bone remodeling marker), phosphorus and transglutaminase IgA (to rule out celiac disease), and DXA scan for bone mineral density (BMD) measurement will be done. The BMD by DXA and 25-hydroxyvitamin D will be correlated to protein, calcium and vitamin D intake obtained by the Block 2014.
PURPOSE: A method for preparing peptides having antibacterial activity is provided to produce a large amount of beta-defensin. CONSTITUTION: A method for in vitro expression of pig beta-defensin comprises: a step of performing PCR using pig tissue-derived cDNA as a template and primer for amplifying beta-defensin; a step of treating restriction enzyme to the PCR product; a step of performing ligation of the PCR product; and a step of transforming an expression vector to a host cell. The primer has a base sequence of sequence number 1 or 2. The host cell is yeast. An antibacterial composition against pathogenic microorganism contains beta-defensin. The pathogenic microorganism is gram-positive such as Bacillus cereus or Bacillus cereus or gram-negative bacteria such as E.coli or Salmonella enteritidis.
A classifier receives policy data corresponding to a new policy. Further, the classifier processes the policy data to classify the policy data into an obligation class and an informational class. An information extractor then extracts metadata from the policy data that is classified into the obligation class. Subsequently, a data translator determines if there is an incremental change in the policy data based on a comparison of the policy data with policy data corresponding to existing policies. On determining the incremental change in the policy data, the data translator translates the policy data that is classified into the obligation class into a rule based on the metadata. A rules engine then receives the rule from the data translator for claims adjudication.
PURPOSE: To obtain a cold-polymerizable dental material capable of assuming a lifelike opalescence color by formulating a microfine titania as an opalescent agent therein. CONSTITUTION: This cold-polymerizable dental material comprises (A) a small amount of a polymerizable resin, preferably a mixture of diglycidyl methacrylate of bisphenol A with triethylene glycol dimethacrylate, (B) a large amount of an organic or an inorganic filler, e.g. a pulverized (meth)acrylate resin, silica or aluminum oxide, (C) a cold-polymerization initiator, e.g. a thermal initiator such as a peroxide or a photoinitiator such as an α-diketone and (D) an microfine titania having a smaller average particle diameter than half of the minimum wavelength of visible rays, i.e., <=0.2μm, especially <=0.6μm average particle diameter.  A value obtained by subtracting a value of ▵b* in a sample of a material having 1mm thickness without containing the component D from the value of ▵b* in a similar sample of the material, containing the microfine titania and having 1mm thickness is preferably >15, especially >20. The amount of the formulated component D is preferably 0.1-0.6wt.% in the case of a restorative and 0.05-2.5wt.% in the case of a cement.
The invention relates to an externally applied medicine for treating an oral mucosa ulcer. The oral mucosa ulcer is a widely developed disease. The number of oral ulcer patients is about 120 millions in the entire country, and the disease is easily recurrent. The invention relates to an externally applied compound powder according to the basic theories of the traditional Chinese medicine and the western medicine, the experience in clinic and the knowledge of the modern pharmacology of the traditional Chinese medicine and the western medicine. The externally applied compound powder is mainly used for treating the oral mucosa ulcer, in particular to recurrent aphtha. The externally applied compound powder comprises the following components: natural indigo, borneol, calcined alum, dexamethasone sodium phosphate and silicate. The externally applied compound powder has the functions of removing necrotic tissues, promoting tissue regeneration, eliminating swelling, sterilizing, carrying out convergence, diminishing inflammation, relieving pain, resisting allergy, and the like and can promote the ulcer to be healed up quickly. The application for three years in clinic proves that the effect is excellent. The externally applied compound powder has the particle size of 200 meshes and is charcoal grey, and the specification is 30g/bottle. The application method comprises the following steps: adhering the externally applied compound powder to special dressing and applying to an ulcer for 5-10 minutes every time and 6-10 times every day.
The aim of this study was to evaluate the potential interplay between a carbohydrate diet and inflammation in atherosclerotic cardiovascular disease (ASCVD) development. ATTICA is a prospective observational study of 3042 adults free of cardiovascular disease (CVD) who were recruited in 2002 and followed for 20 years. Baseline data on carbohydrate intake and inflammatory biomarker levels were collected. Participants were stratified by carbohydrate intake (low vs. high: </> 190 g/day) and carbohydrate quality. At the 20-year follow-up in 2022, 1988 participants had complete data for CVD assessment. The overall quantity and quality of carbohydrate intake did not show a significant association with CVD incidence; inflammatory markers were positively correlated with an increased risk of CVD (p-values < 0.05). Chronic systemic inflammation seems to affect the CVD risk of participants who had a higher carbohydrate intake more substantially, as compared to those with low intake. Additionally, individuals with higher high carbohydrate/low fiber intake experienced a higher risk of inflammation-related CVD, compared to those with high carbohydrate/high fiber intake. The presented findings revealed that the effect of inflammation markers on the CVD risk is influenced both by the amount and quality of carbohydrate intake, irrespective of overall dietary habits and clinical and lifestyle characteristics.
In the Western world, sales of alcoholic beverages are skyrocketing. Alcohol (ethanol) is consumed for its transient euphoric effects but is a risk factor for the development of heart disease. Here, we review the possible association between alcohol consumption and atrial fibrillation. Using a familiar analogy, we propose that atrial fibrillation is the mere tip of an iceberg (alcohol-associated heart disease). Our concern is that the many research studies on the effects of ethanol on the heart have produced inconsistent results. These include studies of individuals drinking only moderate amounts of alcoholic beverages (aka the "French paradox") on the one hand, and paroxysmal atrial fibrillation after binge drinking ("holiday heart syndrome") on the other hand. The evidence available in the literature suggests that hypertension, structured heart disease of any form, neurohumoral stress, and cardiometabolic disorders all favor the development of atrial fibrillation triggered by alcohol. We also suggest that alcohol should be classified as a modifiable risk factor for atrial fibrillation, and also for heart disease in general.
For the active sham stimulation, the stimulation is delivered for 12 seconds with the theta-gamma cross-frequency stimulation waveform and then returns to baseline. The stimulus parameter of the sham stimulation is designed to mimic the adaptive sensations experienced by the subject when receiving the real stimulation treatment settings, but no effective brain modulation will be produced, which assists with blinding the participant's assignment.
Research to understand the sources of health disparities has acknowledged that in addition to biomedical risk factors, culture plays an important role in differential health outcomes. Consequently, understanding cultural differences that may influence health behavior is key in working towards reducing these disparities. Causal attributions are a key component of individuals illness perceptions and thus impact health behaviors, which may present as health disparities at a population level. While research has explored non-Hispanic White women s causal attributions of breast cancer, less is known about Latina s beliefs about the causes of breast cancer, and little is known about causal attributions of colon cancer in any population. Understanding Latina s causal attributions of breast and colon cancer may provide insight into the determinants of cancer disparities in this population. Because a subset of both breast and colon cancers result from single gene mutations, which confer an increased risk of developing such cancers, understanding causal attributions in Latina populations is relevant to the field of genetics. This is especially true since Latinas have historically underutilized cancer genetic risk assessment counseling and testing services. As these services become a standard part of general healthcare provision, it will become increasingly important to understand ways in which different cultural groups interact with genetic information. One way this can be done is through investigating culturally informed mental models of disease risk and inheritance. This study seeks to describe causal attributions of breast and colon cancer and to explore mental models of disease inheritance among Latina immigrants . A qualitative exploratory design including interviews comprised of free-listing, ranking, and open-ended questions will be used. Participants will be recruited through the NIH Clinical Research Volunteer Program as well as using other resources within the Office of Participant Recruitment and from among individuals enrolled on other NIH Clinical Center protocols. First, we will describe Latina s causal attributions for these cancers. Next, we will use cultural consensus theory (CCT) to identify and describe common cultural models of causes of these cancers. Finally, we will explore Latina s mental models of disease inheritance using both free-listing and open-ended questions.
The present study explores the function of FANCA gene, a pivotal member of the Fanconi anaemia (FA) pathway crucial for preserving genomic stability and preventing cancer, particularly in the context of gastric cancer (GC). Using immunohistochemistry, quantitative real-time PCR, and western blot analysis, we evaluate FANCA mRNA and protein expressions in GC cell lines. The relationship between FANCA expression and clinicopathological characteristics is also explored. Various assays, including CCK8, colony formation, wound healing, and Transwell assays, are used to assess functional changes in cells associated with FANCA. Flow cytometry is utilized to evaluate alterations in the cell cycle resulted from FANCA knockdown and overexpression. Our findings show elevated FANCA expression in GC cell lines, with levels correlated with pathologic stage and lymphatic metastasis. FANCA knockdown impedes cell proliferation, migration, and invasion and induces G1/S phase cell cycle arrest. Conversely, FANCA overexpression stimulates cell proliferation, migration, and invasion. In vivo xenograft experiments confirm the promotional role of FANCA in GC tumor progression. Moreover, FANCA overexpression is associated with the activation of cell cycle. Collectively, our results suggest that FANCA drives malignant cell behaviors in GC through the cell cycle pathway, highlighting its potential as a therapeutic target for the treatment of GC.
Based on the experience from the pilot study, a new randomized study is planned with the aim of evaluating a revised treatment program. People 25-69 years with a BMI 30-44.9 kg / m2, or with a BMI 28-29.9 kg / m2 and co-occurrence of hypertension, prediabetes, type 2 diabetes, coronary heart disease, hyperlipidemia, hepatic steatosis, sleep apnea or polycystic ovary syndrome can be included. The intervention group receives increased therapist support with physical or digital meetings before and during the treatment as well as individualized feedback from the therapist. Feedback takes place after 6, 12 and 18 weeks. The other group, the control group, implements the program without meetings with the therapist and receives general feedback during the treatment. The purpose is to evaluate whether increased therapist contact compared to less therapist contact leads to improved weight reduction, quality of life, eating habits and increases physical activity at follow-up after 12 months
FIELD: medicine. SUBSTANCE: method involves cleaning implant surface and applying coating layer. Coating is produced by applying microacrch oxidation in the presence of biologically active agent(s) forming the biologically active coating. The implant is manufactured from a metal to be selected from a group including titanium, aluminum, zirconium. Hydroxyapatite is used as biologically active agent. EFFECT: production of implants showing biological activity. 4 cl, 3 dwg, 1 tbl
Current guideline-defined asthma control cannot be applied to the level of airway inflammation because neither symptoms nor the results of basic pulmonary function tests can reflect ongoing airway inflammation.Consequently, asymptomatic or minimally symptomatic patients are usually considered to have controlled asthma even if they have subclinical airway inflammation. Measures of airway inflammation are thus required to identify patients with silent airway inflammation which does not manifest itself as symptoms or impaired lung function. In addition, measurement should be easy to perform, reproducible, and associated with a high degree of acceptance by patients. In this regard, the advent of FeNO measurements represents a significant advance in monitoring airway inflammation of asthmatic patients. High FeNO values above certain cut-point may indicate active eosinophilic airway inflammation and the likelihood of deterioration in asthma control. However, it is still unclear that high FeNO in asymptomatic patients implies the need for the anti-inflammatory treatment.

Current guidelines for asthma management recommended forced expiratory volume in the first second (FEV1) as a principle spirometric parameter to assess airflow limitation. However, asthmatic subjects have air trapping in the presence of normal FEV1. Air trapping in asthmatic subjects has been demonstrated to be better correlated with forced expiratory flow between 25% and 75% of vital capacity % predicted (FEF25-75 % predicted) than FEV1 % predicted. In fact, impaired FEF25-75 is one of the most common abnormalities in pulmonary function in cross-sectional studies in asymptomatic patients. In addition, high FeNO in asymptomatic or minimally symptomatic patients may be accompanied by impairment of FEF25-75 because both parameters have been suggested to be measures of residual small airway disease. Therefore, there is a possibility that the improvement of FEF25-75 happens concomitantly with the decrease of FeNO during the anti-inflammatory treatment. In this study, we recruited previously well-documented atopic asthmatic children who required no medication to maintain asthma control for more than 3 months and had high FeNO levels (\> 25 ppb). We aimed to assess whether the decrease of FeNO occurs simultaneously with improvement of FEF25-75 after treatment with inhaled corticosteroid (ICS) in these patients.
PURPOSE: This study was a retrospective and nonrandomized study to assess the safety and reliability of identifying the surgical margin in breast cancer breast-conserving surgery (BCS) by using intraoperative ultrasonic location and specimen mammography instead of traditional intraoperative frozen pathological section.
METHODS: Among the patients who underwent BCS from May 2019 to October 2021, according to the different methods of evaluating the intraoperative margin, 104 breast cancer patients were included in the frozen edge group, 53 breast cancer patients were included in the freeze-free group, and the surgeon judged whether extended resection was needed based on the results of pathological section or evaluation of intraoperative ultrasound and mammography. The surgical margins of the two groups were judged by postoperative pathological results as the gold standard.
RESULTS: The median waiting pathology results time in the frozen edge group was 64 minutes, while the waiting time in the freeze-free group was 30 minutes, and the difference was statistically significant (P < .0001). The postoperative pathological results showed that the positive rate of the surgical margin in the frozen edge group was 0.96%. The coincidence rate of intraoperative frozen and postoperative pathological results was 99.04%. The coincidence rate between intraoperative mammography and postoperative pathological results was 100%.
CONCLUSIONS: In BCS, the method of using intraoperative staining markers combined with mammography to evaluate the resection margin is highly accurate, reliable, economical and convenient, and at the same time reduces the waiting time of the operator during the operation. However, this was not a randomized controlled study, and there was patient selection bias, and its safety needs to be confirmed by long-term follow-up. In the future, it is expected to become the mainstream means of evaluating.