anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Clinician stakeholders were physicians, nurses, nurse practitioners, and social workers with expertise in treating advanced cancer patients. Stakeholders reviewed an initial version of the Oncolo-GIST manual to provide feedback and refine the manual for Phase 2.
After intubation, patients in the Treatment Group will receive intraoperative inspired oxygen set at 80 percent (FiO2 of 0.80). Post-extubation, patients in the treatment arm will be placed on high flow non-re-breather mask at 15L/min for up to 2 hours postoperatively and then transitioned to nasal cannula, which will be weaned as tolerated.
Patients meeting the inclusion criteria will be randomized into either the control group of intra-articular injection of 40mg Methylprednisolone once every 2 two weeks for 4 weeks (day 1, week 2, week 4) with 20 patients in each group. Injections will be administered by the treating physician.
The invention belongs to the technical field of medicines, and in particular relates to lactoferrin modified solid lipid nanoparticles, as well as a preparation method and application thereof. The lactoferrin modified solid lipid nanoparticles are characterized in that lactoferrin is modified on the surfaces of solid lipid nanoparticles. The lactoferrin modified solid lipid nanoparticles can wrap medicines therein and can be used as a medicine transfer carrier. The preparation method disclosed by the invention comprises the following steps: synthesising mal-sac-PEG-MS through DCC dehydration reaction, and preparing a nanosuspension by using mal-sac-PEG-MS; then, carrying out lactoferrin sulfhydrylation (Lf-SH) by virtue of a Traut's agent, adding Lf-SH into the nanosuspension, and stirring at a room temperature to carry out protein modification. The lactoferrin modified solid lipid nanoparticles disclosed by the invention have good particle size, Zeta potential and stability. Experimental results show that the lactoferrin modified solid lipid nanoparticles disclosed by the invention are capable of transferring model medicines, such as loperamide and coumarin 6, into brain.
Despite the protective nature of the blood-brain barrier (BBB) and brain-protecting tissues, some types of CNS injury or stress can cause cerebral cytokine production and profound alterations in brain function. Neuroinflammation, which can also be accompanied by increased cerebral cytokine production, has a remarkable impact on the pathogenesis of many neurological illnesses, including loss of BBB integrity and ischemic stroke, yet effective treatment choices for these diseases are currently lacking. Although little is known about the brain effects of Metformin (MF), a commonly prescribed first-line antidiabetic drug, prior research suggested that it may be useful in preventing BBB deterioration and the increased risk of stroke caused by tobacco smoking (TS). Therefore, reducing neuroinflammation by escalating anti-inflammatory cytokine production and declining pro-inflammatory cytokine production could prove an effective therapeutic strategy for ischemic stroke. Hence, the current investigation was planned to explore the potential role of MF against stroke and TS-induced neuroinflammation and reactive oxygen species (ROS) production. Our studies revealed that MF suppressed releasing pro-inflammatory mediators like tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) by aiming at the nuclear factor kappa B (NF-κB) signaling pathway in primary neurons and astrocytes. MF also upregulated anti-inflammatory mediators, like interleukin-10 (IL-10), and interleukin-4 (IL-4), by upregulating the Nrf2-ARE signaling pathway. Adolescent mice receiving MF along with TS exposure also showed a notable decrease in NF-κB expression compared to the mice not treated with MF and significantly decreased the level of TNF-α, IL-1β, MCP-1, and MIP-2 and increased the levels of IL-10 and IL-4 through the activation of Nrf2-ARE signaling pathway. These results suggest that MF has anti-neuroinflammatory effects via inhibiting NF-κB signaling by activating Nrf2-ARE. These studies support that MF could be a strong candidate drug for treating and or preventing TS-induced neuroinflammation and ischemic stroke.
There is no specific antidote for iloperidone tablets. Therefore appropriate supportive measures should be instituted. In case of acute overdose, the physician should establish and maintain an airway and ensure adequate oxygenation and ventilation. Gastric lavage (after intubation, if patient is unconscious) and administration of activated charcoal together with a laxative should be considered. The possibility of obtundation, seizures or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous ECG monitoring to detect possible arrhythmias. If antiarrhythmic therapy is administered, disopyramide, procainamide and quinidine should not be used, as they have the potential for QT-prolonging effects that might be additive to those of iloperidone. Similarly, it is reasonable to expect that the alpha-blocking properties of bretylium might be additive to those of iloperidone, resulting in problematic hypotension. Hypotension and circulatory collapse should be treated with appropriate measures such as intravenous fluids or sympathomimetic agents (epinephrine and dopamine should not be used, since beta stimulation may worsen hypotension in the setting of iloperidone-induced alpha blockade). In cases of severe extrapyramidal symptoms, anticholinergic medication should be administered. Close medical supervision should continue until the patient recovers.
Background: Validated instruments for assessing results after breast surgery are sparse. Investigators want to present a method used for the past 10 years at their institution for evaluation of the outcome after breast conserving surgery (BCS) and microsurgical breast reconstruction. Methods: 346 consecutive patients subjected to BCS for cancer and 30 patients operated with a deep inferior epigastric flap (DIEP ) were assessed at least one year after the operation. The Telemark Breast Score is a method based on standard two-dimensional photographs assessing the outcome after breast surgery in terms of volume, shape and symmetry. Three different panels including plastic surgeons, breast surgeons and nurses were invited to test the Telemark Breast Score. Consistency of agreement between and inside the panel groups was studied Results: Inter- and intra observer reliability was acceptable. Good stability of ratings could be shown in test-retests.

Conclusion: The Telemark Breast Scale is inexpensive, statistically reliable and can be applied for quality control after breast surgery.
Adult neural stem cells (NSCs) in the hippocampal dentate gyrus continuously proliferate and generate new neurons throughout life. Although various functions of organelles are closely related to the regulation of adult neurogenesis, the role of endoplasmic reticulum (ER)-related molecules in this process remains largely unexplored. Here we show that Derlin-1, an ER-associated degradation component, spatiotemporally maintains adult hippocampal neurogenesis through a mechanism distinct from its established role as an ER quality controller. Derlin-1 deficiency in the mouse central nervous system leads to the ectopic localization of newborn neurons and impairs NSC transition from active to quiescent states, resulting in early depletion of hippocampal NSCs. As a result, Derlin-1-deficient mice exhibit phenotypes of increased seizure susceptibility and cognitive dysfunction. Reduced Stat5b expression is responsible for adult neurogenesis defects in Derlin-1-deficient NSCs. Inhibition of histone deacetylase activity effectively induces Stat5b expression and restores abnormal adult neurogenesis, resulting in improved seizure susceptibility and cognitive dysfunction in Derlin-1-deficient mice. Our findings indicate that the Derlin-1-Stat5b axis is indispensable for the homeostasis of adult hippocampal neurogenesis.
Between July 2005 and November 2018, at Edouard Herriot Hospital (Lyon, France), 22 consecutive patients were treated with S-HIFU for a local recurrence after RP and salvage or adjuvant EBRT. The oncological outcomes (treatment failure-free survival, progression-free survival), the adverse events and urinary incontinence were retrospectively reviewed.
Intervention: Rapid on-site evaluation (ROSE) In the EUS-FNB with ROSE arm, the material obtained with the first pass will be processed for ROSE using the touch imprint technique. The biopsy specimen is carefully pressed onto the slide, allowing the superficial cells to adhere, and then gently lifted with forceps thereby creating a touch imprint of the specimen on the slide. In case of inadequate sample, a second pass will be done and the touch imprint technique will be repeated up to a maximum of 3 passes. In case of adequate ROSE at the first or the second pass, the additional passes will be performed as EUS-FNB and the material obtained placed directly into formalin or other fixative for subsequent histopathological evaluation.
Diabetes is common and rapidly increasing, because of obesity, unhealthy eating habits, and physical inactivity in Korea. Many studies reported that lifestyle modification related in the primary prevention of diabetes in multiethnic populations. The aim of this study is to determine whether internet-based interventions in those at high risk may delay the development of type 2 diabetes mellitus, and thereby reduce the incidence of cardiovascular diseases and strokes in Korean populations. In January 2008, participant recruitment began in Chung-ju city, a rural area in Korea. The subjects with impaired glucose tolerance or elevated fasting plasma glucose concentrations were selected from initial screening and then randomized to either a control or intensive lifestyle group to carry out intervention over 4 years. The primary outcome of this study is the development of diabetes by ADA criteria. To confirm the onset of diabetes, all subjects have an OGTT at the interim 6-month and each annual visit. Also, systematic evaluation examination will be done at the same time. The proportion of subjects developing diabetes in each group and the factors relating the progression will be estimated using statistical analysis.
PURPOSE: A composition containing ginseng flower bud extract is provided to protect liver from damage and to prevent alcoholic fatty liver. CONSTITUTION: A composition which prevents alcoholic liver damage or alcoholic fatty liver or reliving hangover contains 10-50 wt% of ginseng flower bud extract. The ginseng flower bud is obtained from Panax ginseng C.A. Meyer, Panax quinquefolium, Panax notoginseng, Panax japonicum, Panax trifolium, or Panax pseudoginseng. A health functional food for preventing alcoholic liver damage or alcoholic fatty liver contains the composition containing ginseng flower bud extract. A pharmaceutical composition for preventing alcoholic liver damage or alcoholic fatty liver contains the ginseng flower bud extract and pharmaceutically acceptable carriers. [Reference numerals] (AA) Group which sample is administered 30 minutes before alcohol administration; (BB) Alcohol concentration in blood
The present invention relates to a topical intranasal antiviral composition for use in the prevention of viral infections. The composition comprises an antigen binding agent and a pharmaceutical suspending agent material for effective release into the nasal cavity. Materials useful for the pharmaceutical suspending agent include microcrystalline cellulose or sodium carboxymethyl cellulose (na.cmc). One particular target for antigen conjugates may be a novel coronavirus. For example, the antigen conjugate may target the S1 subunit of the novel coronavirus. The composition may be prepared by the following method: a pharmaceutical carrier is prepared, then an antigen binding agent is added to the pharmaceutical carrier to prepare a bioactive mixture, and then solid sodium chloride is added to the bioactive mixture. Methods of preventing viral infection using intranasal antiviral compositions are also disclosed. For example, in the case of novel coronaviruses, the antigen binding agent will prevent the viral particles from attaching to ACE2 receptors on the nasal mucosa or host cells of the nasopharynx. This blocking effect can prevent viral infection.
PURPOSE: To provide a new acyl-L-carnitine ester having excellent antimycotic activity and useful for the treatment for infections by yeast-like bacteria or filamentous bacteria.  
     CONSTITUTION: The acyl-L-carnitine ester is expressed by formula I. In formula 1, R is 2 to 16C straight-chain or branched acyl; n is 7 to 15; X -  is a pharmaceutically acceptable acid anion. The ester is, for example, isovaleryl-L-carnitine- undecyl ester chloride. A compd. of formula I with n being 10 to 15 is obtd. by allowing acyl-L-carnitine expressed by formula II to react with a halogenating reagent such as thionyl chloride to obtain an acid chloride expressed by formula III, then allowing the acid chloride to react with a compd. expressed by R 1 OH (R 1  is 11 to 18C alkyl) to obtain a compd. expressed by formula IV, and further allowing the obtd. compd. to react with a compd. of HX. A pharmaceutic containing the compd. of formula I as the effective component is suitable for the treatment for infection by Candida albicans, Candida tropicalis, Candida pseudotropicalis, etc., or infection by Aspergillus fumigatus. 
     COPYRIGHT: (C)1993,JPO
The experimental product contains 180mg (360mg/day) of water soluble pollen extract fraction. Participants will be instructed to take one (1) capsule twice daily before breakfast and dinner with a glass of water for 24 weeks beginning on the Day 1, the day after their baseline visit. If a dose is missed participants are instructed to take the missed dose with the next scheduled dose. Participants will be advised not to exceed 3 capsules daily.
PURPOSE: To obtain an immuno-absorbent useful e.g. for the diagnosis of autoimmune diseases and immunodeficiency by immobilizing a monoclonal antibody specifically bonding to the antigen part of a T-cell growth and differentiation factor on a substrate in a column, etc. CONSTITUTION: An anti-TRF monoclonal antibody (TB13, NC17, etc.) specifically bonding to T-cell growth differentiation factor (TRF) and free from bonding activity to IL-1, IL-2, IL-3 and BSF-1 is immobilized on a supporting material in a column, etc. The immuno-absorbent is useful for the purification of TRF as well as for the application to diagnosis by the quantitative determination of TRF in body fluid and the purified TRF can be used e.g. as an agent for the treatment of immunodeficiency and autoimmune diseases.
The invention discloses an actinobacillus pleuropneumoniae immunoprotective antigen protein APJL _1976 and application thereof. The amino acid sequence of the actinobacillus pleuropneumoniae immunoprotective antigen protein is shown in SEQ ID No.1, the immunoprotective antigen protein consists of 273 amino acids, and the mature polypeptide part of the immunoprotective antigen protein is 21-191 amino acids. The nucleotide sequence for coding the immunoprotective antigen protein is preferably shown as SEQ ID NO. 2. The immunoprotective antigenic protein disclosed by the invention has good immunogenicity and strong immunoprotection effect, and has the application of preparing a kit for detecting actinobacillus pleuropneumoniae antibodies, preparing a porcine pleuropneumonia subunit vaccine and preparing a medicament for preventing diseases caused by actinobacillus pleuropneumoniae. The invention provides a new material for preparing the porcine pleuropneumonia subunit vaccine and has important significance for preventing and controlling the porcine pleuropneumonia.
Computerized WM training with Rehacom will be implemented in daily 30-minute sessions that are scheduled prior to the participant's occupational therapy (OT) session as an adjunct to routine rehabilitation. Tasks are tailored to the participant's current ability level and are adaptive to performance changes. During these sessions, the study staff member will use guided questioning to help the participant anticipate challenges, reflect on performance, and link computerized exercises to the Multicontext sessions. The Multicontext treatment sessions will be delivered within the participant's OT session by an OT. The Multicontext approach helps individuals to self-discover WM-related error patterns and learn to anticipate WM performance challenges through repeated practice using functionally-relevant activities. The OT conducts guided questioning pre- and post-task to help the participant anticipate challenges and self-discover WM strategies.
To individually prescribe rehabilitation contents, it is of importance to know and quantify factors for rehabilitation success and the risk for a future healthcare use. The objective of our multivariable prediction model was to determine factors of rehabilitation success and the risk for a future healthcare use in patients with high-grade, chronic low back pain. We included members of the German pension fund who participated from 2012 to 2019 in multimodal medical rehabilitation with physical and psychological treatment strategies because of low back pain (ICD10:M54.5). Candidate prognostic factors for rehabilitation success and for a future healthcare use were identified using Gradient Boosting Machines and Random Forest algorithms in the R-package caret on a 70% training and a 30% test set. We analysed data from 154,167 patients; 8015 with a second medical rehabilitation measure and 5161 who retired because of low back pain within the study period. The root-mean-square errors ranged between 494 (recurrent rehabilitation) and 523 (retirement) days ( R2 = 0.183-0.229), whereas the prediction accuracy ranged between 81.9% for the prediction of the rehabilitation outcome, and 94.8% for the future healthcare use prediction model. Many modifiable prognostic factors (such as duration of the rehabilitation [inverted u-shaped], type of the rehabilitation, and aftercare measure), nonmodifiable prognostic factors (such as sex and age), and disease-specific factors (such as sick leave days before the rehabilitation [linear positive] together with the pain grades) for rehabilitation success were identified. Inpatient medical rehabilitation programmes (3 weeks) may be more effective in preventing a second rehabilitation measure and/or early retirement because of low back pain compared with outpatient rehabilitation programs. Subsequent implementation of additional exercise programmes, cognitive behavioural aftercare treatment, and following scheduled aftercare are likely to be beneficial.
Standard PEEP (at 7 cmH2o), Vt standardized between \[6- 8\] ml/kg theoretical ideal weight. Taking NIBP every 3 minutes.
FIELD: pharmaceutical industry. ^ SUBSTANCE: invention relates to a complex for the antimicrobial and / or anti-inflammatory action, which contains fulvic acid having a molecular weight not exceeding 20 kDa herewith fulvic acid derived from sugar. The complex can also contains aluminum, mercury, cadmium, chromium and lead in amounts which do not harm human body. The invention also relates to a method of producing the specified complex which comprises dissolving the carbohydrate to form of a solution and oxidation of this carbohydrate in the water vapor. The obtained product, containing acidic components is subjected to filtration to remove acidic components with a molecular mass greater than 20 kDa. ^ EFFECT: invention provides complexes of fulvic acid, which practically does not contain harmful elements such as aluminum, chromium, mercury, other, and can be safely used in the pharmaceutical industry. ^ 26 cl, 2 dwg, 1 tbl, 4, ex
BACKGROUND: This study was conducted to investigate the correlation between KCNQ1 rs2237895 A/C gene polymorphism and blood indexes and prognosis in non-small cell lung cancer (NSCLC).
METHODS: A total of 260 NSCLC patients were selected and classified into stage I - II (n = 109) and stage III - IV (n = 151) according to by American Joint Committee on Cancer Staging Manual. A control group was established with another 92 healthy subjects. The genotype distribution of rs2237895 was analyzed in all subjects. 2 analysis or Fisher's test was employed to analyze the association between genotype and allele distribution frequencies with carcinoembryonic antigen (CEA), squamous cell carcinoma antigen, and cytokeratin fragment 19 (CyfrA 21-1). Overall survival was compared by genotype stratification using Kaplan-Meier analysis. Univariate and multivariate Cox risk regression analyses were used to determine the prognostic value of allele C in NSCLC.
RESULTS: AC/CC genotypes in NSCLC patients were associated with gender, hypertension, smoking, clinical TNM stage, lymph node metastasis, and distant metastasis. C allele was associated with higher risk levels of serum tumor markers. Patients with allele C (AC + CC) had lower overall survival than patients with genotype AA. Finally, clinical stage, lymph node metastasis, higher CEA and CyfrA 21-1 serum levels, and rs2237895 A/C gene poly-morphism were independent prognostic factors of NSCLC.
CONCLUSIONS: rs2237895 A/C polymorphism of the KCNQ1 gene can be a prognostic predictor in patients with surgically treated NSCLC.
Tissue-specific gene expression and gene regulation lead to a better understanding of tissue-specific physiology and pathophysiology. We analyzed the transcriptome and genetic regulatory profiles of two distinct gastric sites, corpus and antrum, to identify tissue-specific gene expression and its regulation. Gastric corpus and antrum mucosa biopsies were collected during routine gastroscopies from up to 431 healthy individuals. We obtained genotype and transcriptome data and performed transcriptome profiling and expression quantitative trait locus (eQTL) studies. We further used data from genome-wide association studies (GWAS) of various diseases and traits to partition their heritability and to perform transcriptome-wide association studies (TWAS). The transcriptome data from corpus and antral mucosa highlights the heterogeneity of gene expression in the stomach. We identified enriched pathways revealing distinct and common physiological processes in gastric corpus and antrum. Furthermore, we found an enrichment of the single nucleotide polymorphism (SNP)-based heritability of metabolic, obesity-related, and cardiovascular traits and diseases by considering corpus- and antrum-specifically expressed genes. Particularly, we could prioritize gastric-specific candidate genes for multiple metabolic traits, like NQO1 which is involved in glucose metabolism, MUC1 which contributes to purine and protein metabolism or RAB27B being a regulator of weight and body composition. Our findings show that gastric corpus and antrum vary in their transcriptome and genetic regulatory profiles indicating physiological differences which are mostly related to digestion and epithelial protection. Moreover, our findings demonstrate that the genetic regulation of the gastric transcriptome is linked to biological mechanisms associated with metabolic, obesity-related, and cardiovascular traits and diseases. NEW & NOTEWORTHY We analyzed the transcriptomes and genetic regulatory profiles of gastric corpus and for the first time also of antrum mucosa in 431 healthy individuals. Through tissue-specific gene expression and eQTL analyses, we uncovered unique and common physiological processes across both primary gastric sites. Notably, our findings reveal that stomach-specific eQTLs are enriched in loci associated with metabolic traits and diseases, highlighting the pivotal role of gene expression regulation in gastric physiology and potential pathophysiology.