anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To lessen the patient's physiological burden by concentrating a peritoneal dialysis liquid by using semipermeable membranes until the plasma protein contained therein attains a specific volumetric concentrating magnification, then diluting the liquid by adding a specific amt. of a physiologically effective liquid thereto. SOLUTION: Concentrating units 11, 15 are formed of the known semipermeable membrane, such as synthetic high-polymer membranes. Electrolyte replenishing units 13, 17 are connected to the outlet conduits of the concentrating units 11, 15 or concd. liquid storage tanks 12, 16 so that the addition of the electrolytic soln. is made possible. The recovered peritoneal dialysis liquid is thickened by the semipermeable membranes of the concentrating units 11, 15 within the range of >=1.5 times the volumetric concentrating magnification and below the moisture content to make the redissolution of the org. matter components in the liquid difficult. This concd. liquid is diluted by adding >=0.5 times the amt. thereof and <=1.000 liter sterile or sterilized electrolytic soln. thereto from the electrolyte replenishing units 13, 17. Such operation is repetitively executed one to plural times.
This study will employ cocaine-dependent individuals to investigate the acute effects of propranolol vs. placebo, administered immediately after a retrieval session of cocaine cue exposure, on the subjective and physiological responses occurring during a subsequent test session of cocaine cue exposure. Participants (N=52) will be randomly assigned to receive 40 mg propranolol or placebo immediately after the first of two cocaine cue exposure sessions scheduled to occur on consecutive days of an inpatient stay at MUSC's General Clinical Research Center (GCRC). The first session will serve as a retrieval session where cocaine cue exposure will putatively elicit retrieval and reconsolidation of memories about the association between the cues and cocaine administration; the second session of cocaine cue exposure will be a test session to examine the potential modulatory role of propranolol on the reconsolidated memories putatively elicited during the previous cue exposure session. It is assumed that changes in craving and physiological reactivity during the test session will reflect propranolol's effects on memory reconsolidation processes elicited by cue exposure during the retrieval session. Medications will be administered in a double-blind fashion. Craving and physiological arousal (heart rate, skin conductance, blood pressure) will be obtained at baseline and at regular intervals during and after both cue exposure sessions. Approximately 7 days following discharge from the inpatient stay at the GCRC, participants will return to the GCRC to undergo a 1-week follow-up cue exposure session that will be identical to the previous two sessions (no medications will be administered). The goal of the follow-up will be to examine if any craving and/or physiological reactivity differences identified during the test session were sustained and to assess if the groups differed in their cocaine use during the intervening 7-day period.
As the investigators know knee osteoarthritis (KOA) is common in elderly people, causes pain, loss of physical functioning, and disability. Knee osteoarthritis (OA) treatment focuses on reducing pain while also enhancing function and quality of life. Increased interest in non-pharmacologic treatments for OA is a result of declining enthusiasm for cyclooxygenase-2 inhibitors as a means of treating knee OA pain and failing clinical trials of OA medications that aim to change the illness. The two hallmarks of non-pharmacologic treatment are resistance training (RT) exercise programs and educational self-management (SM) programs and It has been evident in recent years that RT can have a favorable impact on activity-related energy expenditure, total free-living energy expenditure, and resting energy expenditure (REE) (AEE).Home based training; Home-based exercise, a time-effective and practical treatment option for people with chronic conditions like KOA, is becoming more valued by rehabilitation professionals and researchers. It can performed by patients individually at home, The goal of home-based and hospital-based exercise is the same; that is, to relieve pain and improve function by strengthening lower limb muscles, improving neuromuscular control, and range of joint motion in the affected knees. The main aim of the study is to determine the effectiveness of home-based resistance training as compared to supervised resistance training exercises in the management of knee osteoarthritis in terms of pain, ROM , disability, muscle strength and spatiotemporal parameter of gait. The participants meeting the eligibility criteria will be recruited, followed by random allocation to 2 groups. Both groups will receive standard treatment protocol which consists resistant training .12 sessions will be provided on alternative days. Pre and Post assessment of will be noted .
An apparatus is disclosed for maintaining records for dental treatment. A registered user of the apparatus has his or her name and address stored in a randomly distributed manner in a systems parameters database 15 in a user-unalterable manner which is integrally linked with a security code. A control unit 2 includes circuits constructed to retrieve the name and address on printing of documents at a printer 7. Accordingly, the name of an unauthorised user will not appear on the documents. Thus, unauthorised use is discouraged in a simple manner. Video controller instructions for a graphical outline chart representing teeth are stored in a graphical record database 13 together with treatment codes for each patient. The treatment codes are used by the control unit 2 in generation of pixels of different colours indicating (Fig 2) treatment required or already carried out. This helps to eliminate mistakes in dental records and work and improves efficiency. <IMAGE>
NEW MATERIAL:An antibody specifically reactive with human immunoglobulin E (IgE). USE:Reagent for immunochemical determination of human IgE. A reagent for determination of human IgE having different light-chain type. PREPARATION:An animal is immunized with human IgE and the spleen cell is extracted to prepare an antibody-producing cell. The antibody-producing cell is fused with a tumor cell e.g. in RPMI-1640 medium in the presence of 40% polyethylene glycol to obtain hybridoma, from which a hybridoma capable of producing anti-human IgE monoclonal antibody is selected usually by ELISA method. The selected hybridoma is cultured e.g. in peritoneal cavity of a mouse, etc., and the objective antibody is recovered from the cultured product by conventional method.
Alzheimer's disease (AD) is characterized by a loss of neurons in the cortex and subcortical regions. Previously, we showed that the progressive degeneration of subcortical monoaminergic (MAergic) neurons seen in human AD is recapitulated in the APPswe/PS1ΔE9 (APP/PS) transgenic mouse model. Because degeneration of cholinergic (Ach) neurons is also a prominent feature of AD, we examined the integrity of the Ach system in the APP/PS model. The overall density of Ach fibers is reduced in APP/PS1 mice at 12 and 18 months of age but not at 4 months of age. Analysis of basal forebrain Ach neurons shows no loss of Ach neurons in the APP/PS model. Thus, since MAergic systems show overt cell loss at 18 months of age, the Ach system is less vulnerable to neurodegeneration in the APP/PS1 model. We also examined whether the proximity to Aβ deposition affected the degeneration of Ach and 5-HT afferents. We found that the areas closer to the edges of compact Aβ deposits exhibit a more severe loss of afferents than the areas that are more distal to Aβ deposits. Collectively, the results indicate that the APP/PS model recapitulates the degeneration of multiple subcortical neurotransmitter systems, including the Ach system. In addition, the results indicate that Aβ deposits cause global as well as local toxicity to subcortical afferents.
Postoperative venous thromboembolic events (VTEs), such as lower extremity deep vein thrombosis (DVT), are major risk factors for gastric cancer (GC) patients following radical gastrectomy. Accurately predicting and managing these risks is crucial for optimal patient care. This retrospective case‒control study involved 693 GC patients from our hospital who underwent radical gastrectomy. We collected plentiful and comprehensive clinical indicators including a total of 49 baseline, preoperative, surgical and pathological clinical data. Using univariate logistic regression, we identified potential risk factors, followed by feature selection through the Boruta algorithm. We then constructed the final predictive model using multivariate logistic regression and evaluated it using receiver operating characteristic (ROC) curve analysis, calibration plots, decision curve analysis, and other methods. Additionally, we applied various machine learning techniques, including decision trees and random forests, to assess our model's predictive strength. This retrospective case‒control study involved 693 GC patients from our hospital who underwent radical gastrectomy. We collected plentiful and comprehensive clinical indicators including a total of 49 baseline, preoperative, surgical and pathological clinical data. Using univariate logistic regression, we identified potential risk factors, followed by feature selection through the Boruta algorithm. We then constructed the final predictive model using multivariate logistic regression and evaluated it using receiver operating characteristic (ROC) curve analysis, calibration plots, decision curve analysis, and other methods. Additionally, we applied various machine learning techniques, including decision trees and random forests, to assess our model's predictive strength. Univariate logistic analysis revealed 14 risk factors associated with postoperative lower limb DVT. Based on the Boruta algorithm, six significant clinical factors were selected, namely, age, D-dimer (D-D) level, low-density lipoprotein, CA125, and calcium and chloride ion levels. A nomogram was developed using the outcomes from the multivariate logistic regression analysis. The predictive model showed high accuracy, with an area under the curve of 0.936 in the training set and 0.875 in the validation set. Various machine learning algorithms confirmed its strong predictive capacity. MR analysis revealed meaningful causal relationships between key clinical factors and DVT risk. Based on various machine learning methods, we developed an effective predictive diagnostic model for postoperative lower extremity DVT in GC patients. This model demonstrated excellent predictive value in both the training and validation sets. This novel model is a valuable tool for clinicians to use in identifying and managing thrombotic risks in this patient population.
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid antagonists, depending on the patient's clinical status [see OVERDOSAGE]. Carbon dioxide (CO2) retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids.

While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of butorphanol tartrate, the risk is greatest during the initiation of therapy or following a dosage increase. 

To reduce the risk of respiratory depression, proper dosing and titration of butorphanol tartrate are essential [see DOSAGE AND ADMINISTRATION]. Overestimating the butorphanol tartrate dosage when converting patients from another opioid product can result in a fatal overdose with the first dose. 

Opioids can cause sleep-related breathing disorders including central sleep apnea (CSA) and sleep-related hypoxemia. Opioid use increases the risk of CSA in a dose-dependent fashion. In patients who present with CSA, consider decreasing the opioid dosage using best practices for opioid taper [see DOSAGE AND ADMINISTRATION].
Compositions selected from detergents and cleaning agents and cosmetic agents are described. The compositions include biodegradable microcapsules including a core material and a shell. The shell includes at least one barrier layer and one stability layer. The barrier layer surrounds the core material. The stability layer includes at least one biopolymer, and is arranged on the outer surface of the barrier layer. An emulsion stabilizer is arranged at the transition between the barrier layer and the stability layer. Use of these agents is also described.
Cerebral hemorrhage, subarachnoid hemorrhage, and stroke have occurred in patients treated with 5-HT1 agonists, and some have resulted in fatalities. In a number of cases, it appears possible that the cerebrovascular events were primary, the 5-HT1 agonist having been administered in the incorrect belief that the symptoms experienced were a consequence of migraine when they were not. Also, patients with migraine may be at increased risk of certain cerebrovascular events (e.g., stroke, hemorrhage, TIA). Discontinue Sumavel DosePro if a cerebrovascular event occurs. 

Before treating headaches in patients not previously diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, exclude other potentially serious neurological conditions. Sumavel DosePro is contraindicated in patients with a history of stroke or TIA.
PURPOSE: Rhodiola rosea fermentation product which contains high aglycon content of salidroside is provided to have excellent active related to anti-fatigue or improvement of exercise capacity and be favorable to absorb high aglycon content of salidroside. CONSTITUTION: Mixing extract of Rhodiola rosea and red ginseng is manufactured by mixing Rhodiola rosea extract with extract of red ginseng, or mixing Rhodiola rosea with red ginseng. Mixture of Rhodiola rosea and red ginseng is fermented by inoculating with lactobacillus. Mixing ratio of Rhodiola rosea and red ginseng or mixing ratio of Rhodiola rosea extract and red ginseng extract are 60 : 40 through 10 : 90. Solid content of Rhodiola rosea is 0.1 to 0.8 weight% at mixing extract of Rhodiola rosea and red ginseng. Lactobacillus is more than one selected among lactobacillus acidophilus [KCTC 2182], bifidobacterium longum[ATCC 15707], Bipidobacterium brevis[ATCC 15700], and Pediococcus pentosaceus [KCCM 11088P]. Fermentation process is performed at 25 through 40 °C for 24 through 96 hours. [Reference numerals] (AA) Example 3 (ug/mL)
The purpose of this prospective randomized controlled trial is to compare the effectiveness of two different delivery methods for postoperative pain management following cardiac surgery requiring median sternotomy: intermittent programmed LA bolus versus continuous LA infusion through ESP catheters. Effectiveness of analgesia will be assessed based on the subjects' NRS pain scores and opioid consumption. The primary outcome measure will be the patients' opioid consumption over the course of the 72 hours following surgery. Secondary outcomes measures that will be evaluated include NRS pain scores, intensive care unit (ICU) length of stay, and time to first dose of antiemetic in the postoperative period. It is hypothesized that the use of intermittent programmed LA boluses will provide better analgesia compared to continuous LA infusion through ESP catheters. The findings of this study will provide guidance regarding the optimal method of delivery for postoperative pain management in patients following cardiac surgery.
PROBLEM TO BE SOLVED: To obtain a bleaching sheet pack cosmetic having excellent effectiveness of bleaching effect and excellent appearance and usability by including a specific amount of keratinase and keratolytic component and preparing to have transparent or translucent appearance. SOLUTION: The objective cosmetic is produced by including a ketatinase and/or a keratolytic component e.g. an α-hydroxy acid or β-hydroxy acid such as salicylic acid, glycolic acid, pyruvic acid, citric acid and malic acid or an enzyme such as papain or protease in an amount of 0.1-10 wt.% in terms of solid component based on the cosmetic excluding the substrate. The cosmetic is judged to be 'transparent' when a black line (2 mm wide) drawn on a white paper is clearly visible through the cosmetic pasted on the paper and to be 'translucent' when the black line is dimly visible. The cosmetic is preferably a gelatinous sheet composed of e.g. a synthetic polymer at least having a network structure and a water-containing solvent.
Several maternal genetic variations are known to play an important role during pregnancy since they can affect mother health and/or fetal growth. The frequency of these variants is variable among different populations. This study aimed to investigate thrombophilia, folate metabolism and hypertension genetic variants in reproductive age women of Rostov region (Russia) and then assess their linkage disequilibrium (LD) and heterogeneity among populations. A total of 3108 reproductive age women were included (33.75 ± 5.13 years). Twenty-one genetic variants were detected with RT-PCR. LD was tested according to (D') coefficient and p value. The highest frequency of mutant allele in studied population was as follows: PAI-1 rs1799768, MTRR rs1801394, AGT rs699, and AGTR2 rs1403543. We showed a high possibility of coinheritance of MTHFR rs1801133 with rs1801131 and AGT rs699 with rs4762 (D'=0.992 and 0.999, respectively). In addition, comparative analysis showed F7 rs6046, FGB rs1800790, MTR rs1805087, and AGT rs699 significantly more frequent among Rostov females by 1.3-1.5 times than European. MTHFR rs1801133, ADD1 rs4961, AGTR2 rs1403543, NOS3 rs2070744, and rs1799983 were with higher frequencies in Europeans than those in the studied group. Our data could be used as a reference for further associative studies of targeted genetic variations in different pregnancy complications specifically in this population.
FIELD: medicine. SUBSTANCE: method involves twice intravenously injecting erythrocytes at a dose of 1 ml of 5% suspension in medium 199 containing 83*10 8  cells to experimental animals before immunizing into exterior tail vein. Erythrocyte suspension is preprocessed with ultrasonic radiation. Exposure is carried out by means of an ultrasonic apparatus at 0.88 MHz frequency and power flux density of 0.4 W/qu cm. EFFECT: enhanced effectiveness in stimulating immune response; excluded interference of undesirable chemical agents. 1 dwg , 4 tbl
The present invention provides for a method of promoting motor neuron survival, growth or differentiation comprising treating motor neurons with an effective amount of HGF. The invention also provides for a method of promoting motor neuron survival, growth or differentiation comprising treating motor neurons with an effective amount of HGF and an effective amount of CNTF. The invention further provides for a method of alleviating the toxic effects of vincristine on motor neurons comprising treating motor neurons with an effective amount of HGF and an effective amount of CNTF. The methods may be carried out in vitro or in vivo. The invention also provides a method of treating a motor neuron disorder in a patient comprising administering to the patient an effective amount of HGF and CNTF. The invention further provides a pharmaceutical composition for treating a motor neuron disorder in a patient comprising HGF and CNTF in a pharmacologically acceptable carrier.
The rising public health burden of opioid misuse, coupled with high relapse rates among individuals seeking treatment for opioid use disorder, necessitates novel interventions for improving opioid-related treatment response. Mobile technology such as smartphone-based applications ("apps") represent one such intervention. Although smartphone apps are effective in reducing cigarette and alcohol use, their efficacy for reducing opioid use has not yet been established. The proposed clinical trial would evaluate the app OptiMAT ("Optimizing Medication-Assisted Treatment") to prevent relapse among patients receiving medication-assisted treatment for opioid use disorder. OptiMAT implements two features shown to be effective for reducing substance use: daily self-monitoring of opiate use coupled with personalized feedback. Aim 1 would accrue 255 participants with 1:1 randomization into two arms (OptiMAT vs. Monitoring only) to evaluate differences in monthly opioid use at six months post-enrollment. Aim 2 would enroll a subset of participants (N=120; 60 per arm) into a longitudinal functional neuroimaging (fMRI) study to model the neurocognitive mechanisms underlying individual differences in treatment response. Two putative mechanisms (attentional bias for drug cues and cue-induced craving) promoting abstinence would be studied. Aim 3 would explore the use of location-based geographic ecological momentary assessment (GEMA) for targeted intervention when participants enter self-identified areas of high risk for relapse. Collectively, the proposed aims would (1) evaluate mobile technology applications for reducing opiate use, (2) understand the neurocognitive mechanisms of action to improve upon this and other apps aiming to reduce drug use, and (3) evaluate the role of personalized, contextually-relevant intervention to promote successful treatment outcomes.
The present invention discloses embryonic egg health-care food and a manufacture method thereof. Embryo eggs are used as major ingredients of the embryonic egg health-care food, and sesame is used as an auxiliary material. The present invention is composed of the following raw materials (the matching is counted by weight) of 7 to 12 portions of animal embryo eggs and 1 to 3 portions of black sesame; 1 to 3 portions of fleece-flower roots and /or 1 to 3 portions of walnut can also be added in order to further increase the health care efficiency of hair blacking. The embryonic egg health-care food of the present invention can not only have the action of promotion of growth and development of a human body, prevention of arteriosclerosis, brain tissue aging, osteoporosis, blood lipid reduction, obesity prevention, immunity strengthening, resistance strengthening, etc. but also have certain action on excitement of youth activity, and aglow and shining skin. The present invention is not only suitable for fat people with slight high blood fat, but also health food for children, women, old people and the invalid. In addition, the health-care food of the present invention is conveniently orally administrated and can be directly eaten. No chemical additive is added, and the present invention is safe health foods which can be orally administrated by people with reassurance.