anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses GPC3CAR-T cells and application thereof in preparation of medicines for treating cancers. Also disclosed is a GPC 3-targeting CAR molecule, a CAR molecule and switch receptor combination, and immune response cells containing the same. The CAR molecule comprises an extracellular domain that specifically binds GPC3, a CD8 hinge region, a CD8 transmembrane region, a costimulatory signal region, and a CD3 zeta signaling domain, the extracellular domain that specifically binds GPC3 comprising the amino acid sequence shown as SEQ ID No. 2 or SEQ ID No. 4. The CAR molecule can kill tumors in vitro with high efficiency, secrete a large amount of cytokines and promote the rapid proliferation of CAR-T cells, and has higher safety. The CAR molecule binds to the conversion receptor, so that the proliferation capacity of the CAR-T cells can be further enhanced, the killing function of the CAR-T cells is obviously improved, and the tumor is rapidly inhibited.
Admixtures of Octagam 5% liquid with other drugs and intravenous solutions have not been evaluated. It is recommended that Octagam 5% liquid be administered separately from other drugs or medications which the patient may be receiving. The product should not be mixed with IGIVs from other manufacturers.

The infusion line may be flushed before and after administration of Octagam 5% liquid with either normal saline or 5% dextrose in water.

Various passively transferred antibodies in immunoglobulin preparations can confound the results of serological testing.

Antibodies in Octagam 5% liquid may interfere with the response to live viral vaccines, such as measles, mumps, and rubella. Physicians should be informed of recent therapy with IGIVs, so that administration of live viral vaccines, if indicated, can be appropriately delayed 3 or more months from the time of IGIV administration.
PURPOSE:A powerful remedy for diarrhea containing powdery charcoal without side effect. CONSTITUTION:A remedy for diarrhea containing powdery charcoal, e.g. charcoal for fuel or adsorption. The charcoal is powdered for facilitating administration, and enhancing the antidiarrheic effect. The particle or grain size of the charcoal is preferably minimized. The dosage form is powder, granule, tablet, sugar-coated tablet, etc. The sufficient dose thereof is 2.5-3.5g for adults or 1.2-1.7g for children administered usually once. Other chemicals, e.g. various vitamins or drugs for controlling intestinal function, contained in the remedy permits the early recovery of the stomach and intestines weakened by the diarrhea.
Beef meat, whose proteins were intrinsically labelled with 15 N, was previously obtained by infusing 15N ammonium sulphate during 50 days in the rumen of an heifer. Two different cooking conditions have been applied to this meat (5 min at 55°C vs 30 min at 90°C). Ten healthy elderly volunteers will test each processed meat according to a cross-over design, during 2 different metabolic studies separated by at least 2 weeks. Volunteers will be submitted to a diet controlled for its protein content, for 4 days (1.2 g protein/kg/day) before each metabolic investigation.

On the 2 days of metabolic investigations, after an overnight fast, blood samples will be collected for basal measurements. Then the subjects will be perfused with L-\[1-13C\] leucine for 9h30 hours, during which expired gas and blood samples will be regularly taken, and CO2 production measured. The volunteers will be asked to eat a 130 g beef meat 2.5h after the onset of the perfusion. Isotopic enrichments in expired gas, in plasma alpha-cetoiscaproate and in free leucine will be measured to determine whole body amino acids fluxes (oxidation, protein synthesis and proteolysis). 15N enrichments of leucine will allow splanchnic extraction measurement.
Leukocyte antibodies can cause febrile transfusion reactions, pulmonary reactions to granulocyte transfusions, and transfusion related acute lung injury (TRALI). Despite the fact that the role of leukocyte antibodies in these reactions was first described almost 50 years ago, and that TRALI is now the leading cause of transfusion related fatalities, much remains uncertain concerning the role of HLA antibodies in these reactions. The primary purpose of this study is to retrospectively and prospectively determine if the incidence and nature of transfusion reactions differs in Clinical Center (CC) patients that were transfused with platelet components from donors with HLA antibodies and those without HLA antibodies. In addition, this study will prospectively determine the incidence of HLA antibodies in the NIH Department of Transfusion Medicine (DTM) platelet donor population. In this natural history study a 10-mL blood sample will be drawn from 600 platelet donors at the time that they are in the DTM donating platelets and it will be tested for HLA antibodies in the DTM. The blood sample for HLA antibody testing will be collected with other samples collected as part of the regular platelet donation process. Reactions in platelet transfusion recipients will be assessed by reviewing CC and DTM patient records.
The majority of manual wheelchair users (MWCU) develop shoulder pain or injuries, which is often caused by impingement. Because propulsion mechanics are influenced by the recovery hand pattern used, the pattern may affect shoulder loading and susceptibility to injury. Shoulder muscle weakness is also correlated with shoulder pain, but how shoulder loading changes with specific muscle group weakness is unknown. Musculoskeletal modeling and simulation were used to compare glenohumeral joint contact forces (GJCFs) across hand patterns and determine how GJCFs vary when primary shoulder muscle groups are weakened. Experimental data were analyzed to classify individuals into four hand pattern groups. A representative musculoskeletal model was then developed for each group and simulations generated to portray baseline strength and six muscle weakness conditions. Three-dimensional GJCF peaks and impulses were compared across hand patterns and muscle weakness conditions. The semicircular pattern consistently had lower shear (anterior-posterior and superior-inferior) GJCFs compared to other patterns. The double-loop pattern had the highest superior GJCFs, while the single-loop pattern had the highest anterior and posterior GJCFs. These results suggest that using the semicircular pattern may be less susceptible to shoulder injuries such as subacromial impingement. Weakening the internal rotators and external rotators resulted in the greatest increases in shear GJCFs and decreases in compressive GJCF, likely due to decreased force from rotator cuff muscles. These findings suggest that strengthening specific muscle groups, especially the rotator cuff, is critical for decreasing the risk of shoulder overuse injuries.
The invention relates to an application of a USP10-MOF-ANXA2 signal pathway as a drug target in preparing a drug for treating esophageal squamous cell carcinoma. The USP10-MOF-ANXA2 signaling pathway includes USP10, MOF and ANXA2 genes. The mRNA nucleotide sequence of the USP10 gene is shown as SEQ ID NO.1, the mRNA nucleotide sequence of the MOF gene is shown as SEQ ID NO.2, and the mRNA nucleotide sequence of the ANXA2 gene is shown as SEQ ID NO. 3. The invention discovers that the proliferation, migration and invasion of esophageal squamous cell carcinoma cells can be effectively inhibited by interfering a USP10-MOF-ANXA2 signal pathway for the first time. The invention also finds that the mixture si-UMA of si-USP10, si-MOF and si-ANXA2 is used for simultaneously and specifically knocking down the mRNA expression levels of USP10, MOF and ANXA2, and the effect of simultaneously knocking down the mRNA expression levels of USP10, MOF and ANXA2 on the inhibition effect of the USP10-MOF-ANXA2 signal path is optimal, so that the effect of inhibiting the proliferation and metastasis of esophageal squamous cell carcinoma is optimal, and the method can be applied to the research and development of targeted therapeutic drugs for esophageal squamous cell carcinoma.
BACKGROUND/AIMS: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper and lower GI tract in concomitant aspirin and acid suppressant users using the nationwide database of national claims data from the Korean National Health Insurance Service (NHIS).
METHODS: An aspirin cohort was constructed using the NHIS claims data from 2013 to 2020. Patients who manifested with hematemesis, melena, or hematochezia were considered to have GI bleeding. A Cox proportional hazards regression model was used to determine the risk factors for GI bleeding associated with the concomitant use of GI drugs and other covariates among aspirin users.
RESULTS: Overall, a total of 432,208 aspirin users were included. The concurrent use of an acid suppressant and eupatilin (hazard ratio [HR] = 0.85, p = 0.016, vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Moreover, a more than 3-month duration (HR = 0.88, p = 0.030) of acid suppressant and eupatilin prescription (vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding.
CONCLUSION: Eupatilin administration for ≥ 3 months showed additional preventive effect on GI bleeding in concomitant aspirin and acid suppressant users. Thus, cotreatment with eupatilin with a duration of 3 months or longer is recommended for reducing GI bleeding among aspirin plus acid suppressant users.
The present invention relates to a traditional Chinese medicine and preparation technique, particularly to a medicine for curing onychomycosis and hand-foot ringworm and a preparing method thereof. The present invention has the solution proposal that disinfecting liquid extracted from natural plants is developed by combining long term research with folk experience in a strict and scientific recipe and a technological process. The product has favorable sterilizing action on staphylococcus aureus and candida albicans. The present invention is composed of the following components and the method (the content of the following components measured by the weight percentage): 5 to 30% of garlic, 5 to 20% of pseudolarix barks, 5 to 20% of cloves, 2 to 10% of fructus cnidii, 2 to 15% of flavescent sophora roots and 5 to 40% of glacial acetic acid. The liquid medicine of the present invention, which is made from the components by a strict process and is suitable for the treatment for onychomycosis and hand-foot ringworm infected by various kinds of pathogenic fungus, can improve cure effect and shorten cure period. Beside, the medicine for curing onychomycosis and hand-foot ringworm has the characteristics of prevention and through cure.
The aim of this review was to examine the current literature regarding the effect of maternal lifestyle interventions (i.e., diet and physical activity) on the epigenome of the offspring. PubMed, Scopus and Cochrane-CENTRAL were screened until 8 July 2023. Only randomized controlled trials (RCTs) where a lifestyle intervention was compared to no intervention (standard care) were included. Outcome variables included DNA methylation, miRNA expression, and histone modifications. A qualitative approach was used for the consideration of the studies' results. Seven studies and 1765 mother-child pairs were assessed. The most common types of intervention were dietary advice, physical activity, and following a specific diet (olive oil). The included studies correlated the lifestyle and physical activity intervention in pregnancy to genome-wide or gene-specific differential methylation and miRNA expression in the cord blood or the placenta. An intervention of diet and physical activity in pregnancy was found to be associated with slight changes in the epigenome (DNA methylation and miRNA expression) in fetal tissues. The regions involved were related to adiposity, metabolic processes, type 2 diabetes, birth weight, or growth. However, not all studies showed significant differences in DNA methylation. Further studies with similar parameters are needed to have robust and comparable results and determine the biological role of such modifications.
Participants are visited twice a week by buddies, but they do not specifically monitor the nutritional status or perform physical training in the first 10-12 weeks. Instead of that buddies are provided with a portfolio of possible activities, especially cognitive training, which they could perform together with the frail, malnourished subjects.
The invention provides 1-(cinnamoyl)-4-(cyclopentylamine acetyl) piperazidine and a preparation containing 1-(cinnamoyl)-4-(cyclopentylamine acetyl) piperazidine and a pharmaceutic adjuvant. 1-(cinnamoyl)-4-(cyclopentylamine acetyl) piperazidine maleate is a derivate of cinepazide, and experiments verify obvious pharmacological effect thereof. The invention concretely provides two injections of the compound, namely solution type and liposome type injections and preparation processes thereof. The solution type injection contains 30-45g of the compound, 20-30g of D-sorbierite, 2-3.5g of disodium hydrogen phosphate and an appropriate amount of water for injection. The preparation method of the solution type injection comprises the following steps: adding the D-sorbierite into water to be dissolved, adding the derivate into the D-sorbierite solution, stirring to partly dissolve the derivate, adding partial disodium hydrogen phosphate solution to completely dissolve the derivate, then regulating the pH value, and filtering, thus the injection preparation is obtained. The liposome type injection contains 1g of the derivate, 1-13g of phospholipid and 0.6-6g of cholesterol. The invention provides a compound with obvious pharmaceutical effect and also provides two safe and stable formulations of the compound and preparation methods thereof.
<P>PROBLEM TO BE SOLVED: To provide an improved prescription for a hydrophobic bioactive substance enhancing stability in an aqueous environment and enabling effective delivery of such substance to a desired action site.  <P>SOLUTION: There are provided a composition for delivery of a bioactive factor to an individual and a method therefor. A delivery vehicle is provided which contains the bioactive factor in a disc-shaped particle containing at least a lipid-bonding polypeptide which surrounds the circumference of a lipid double layer in which the bioactive factor is localized. A chimeric lipid-bonding polypeptide is also provided, and the polypeptide can be used for addition of further functional characteristics to the delivery particle. A particle which is a delivery particle of the bioactive factor containing a lipid-bonding polypeptide, a lipid double layer and the bioactive factor is provided, and a hydrophobic region is contained inside the lipid double layer and the bioactive factor is bonded to the hydrophobic region of the lipid double layer.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Participants will have one eye randomized to receive the intense pulsed light (IPL) therapy treatment while their other eye will receive the sham treatment. Participants will receive approximately 15 light spots to areas around the eye, lower eyelid, cheek, side of the nose and temple. The energy level will be based on skin type. IPL will be administered 4 times throughout the study.
The present invention relates to a system for prescribing and delivering health functional food suitable for a client′s body function. According to the present invention, a client signs up on a health functional food homepage, and then a nurse as a health functional food company administrator has a face-to-face interview with the client. Then, body composition measurement and analysis data obtained by measuring the client′s body function with a delivered body composition measurement and analysis device is transmitted by the client with a wired/wireless device to the health functional food company′s database and management server. Then, the management server performs integrated client health information analysis and assessment based on the client body composition measurement and analysis data and generates health food prescription information for the client by interworking with health food data and health food efficacy information data in the database. Based on the health food prescription information, the nurse and the client have a face-to-face interview or the nurse and the client carry out consultation by wired/wireless communication or network. Then, the health functional food suitable for the client′s body function is delivered to the client. According to the present invention, the health functional food is systematically and scientifically prescribed based on the body composition measurement and analysis data on the client, and thus the client′s health can be promoted and disease can be prevented.
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:5, 2, or 10, the nucleotide sequence set forth in SEQ ID NO:4, 1, 3, 4, 6, 9, or 11, or the nucleotide sequence deposited in a bacterial host as Accession No. B-50045, as well as variants and fragments thereof.
INTRODUCTION: The indication of preoperative prophylaxis in the insertion of indwelling tunneled central venous catheters (ITCVC) has a low level of evidence. Our objective was to assess risk factors of ITCVC-related early bacteremia in oncological pediatric patients and to determine the need for preoperative prophylaxis.
MATERIALS AND METHODS: A univariate and multivariate retrospective analysis of patients in whom an ITCVC was placed from January 2020 to July 2023, according to whether they had ITCVC-related early bacteremia (EB) in the first 30 postoperative days, was carried out. Demographic variables, leukopenia, neutropenia, use of preoperative antibiotic prophylaxis, and history of central venous catheter (CVC) or bacteremia were collected. Calculations were carried out using the IBM SSPS29® software.
RESULTS: 176 patients with a mean age of 7.6 years (SD: 4.82) were analyzed. 7 EB cases were identified, with a greater frequency of neutropenia (p= 0.2), history of CVC in the 48 hours before insertion (p= 0.08), and intraoperative CVC (p= 0.04). The presence of intraoperative CVC increased the risk of EB 9-fold [OR: 9.4 (95%CI: 1.288-69.712) (p= 0.027)]. The lack of preoperative prophylaxis did not increase the risk of EB [OR: 2.2 (CI: 0.383-12.669) (p= 0.3)]. The association with other variables was not significant.
CONCLUSIONS: The intraoperative presence of CVC was a risk factor of EB in our patients. Preoperative prophylaxis had no impact on the risk of EB, which in our view does not support its use. However, further studies with a larger sample size are required. Leukopenia or neutropenia at diagnosis were not associated with a greater prevalence of infection.
Subect receives standard high-risk prenatal care and postpartum contraception provision by the referring community clinic. The community clinic offer standard family planning counseling that does not emphasize utilizing of long-acting reversible contraception to promote birth-to-pregnancy spacing of 18 months. This scenario is current the standard practice at the institutions.
Participants aged 6 months to \<18 years with melanoma receive pembrolizumab, starting dose 2 mg/kg (maximum dose 200 mg), intravenously (IV) once every 3 weeks (Q3W). Enrollment of participants aged 6 months to \<12 years with melanoma was closed with Amendment 8. Enrollment of participants aged ≥12 years to ≤18 years with melanoma continues.
BACKGROUND: Voltage mapping to detect ventricular scar is important for guiding catheter ablation, but the field-of-view of unipolar, bipolar, conventional, and microelectrodes as it relates to the extent of viable myocardium (VM) is not well defined.
OBJECTIVES: The purpose of this study was to evaluate electroanatomic voltage-mapping (EAVM) with different-size electrodes for identifying VM, validated against high-resolution ex-vivo cardiac magnetic resonance (HR-LGE-CMR).
METHODS: A total of 9 swine with early-reperfusion myocardial infarction were mapped with the QDOT microcatheter. HR-LGE-CMR (0.3-mm slices) were merged with EAVM. At each EAVM point, the underlying VM in multisize transmural cylinders and spheres was quantified from ex vivo CMR and related to unipolar and bipolar voltages recorded from conventional and microelectrodes.
RESULTS: In each swine, 220 mapping points (Q1, Q3: 216, 260 mapping points) were collected. Infarcts were heterogeneous and nontransmural. Unipolar and bipolar voltage increased with VM volumes from >175 mm3 up to >525 mm3 (equivalent to a 5-mm radius cylinder with height >6.69 mm). VM volumes in subendocardial cylinders with 1- or 3-mm depth correlated poorly with all voltages. Unipolar voltages recorded with conventional and microelectrodes were similar (difference 0.17 ± 2.66 mV) and correlated best to VM within a sphere of radius 10 and 8 mm, respectively. Distance-weighting did not improve the correlation.
CONCLUSIONS: Voltage increases with transmural volume of VM but correlates poorly with small amounts of VM, which limits EAVM in defining heterogeneous scar. Microelectrodes cannot distinguish thin from thick areas of subendocardial VM. The field-of-view for unipolar recordings for microelectrodes and conventional electrodes appears to be 8 to 10 mm, respectively, and unexpectedly similar.