anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To provide an antitumor agent containing the saponin component of AMACHAZURU as an active substance. CONSTITUTION:The whole grass of AMACHAZURU (Gynostemma pentaphyllum Makino) or its dried product is extracted with water or a lower aliphatic alcohol, etc., and concentrated to obtain an extract. The extract is defatted with a fat-dissolving organic solvent, and at the same time, the most part of chlorophyll is removed. The product is dissolved in a water-saturated n-butanol, added with water, stirred, and left at rest. The upper n-butanol layer is separated, and the sugars, pigments, etc are removed together with water. The n-butanol layer is evaporated to dryness, dissolved in a lower aliphatic alcohol, and poured into a large amount of ether or benzene under stirring. The precipitated substance is separated by filtration, and dried to obtain a saponin component. The objective antitumor agent can be prepared by using the saponin component as an active component. It is administered in the form of oral drug, injection for parenteral use, and drug for external application. Dose: 20-500mg/daily in 2-3 divided doses for oral administration.
INTRODUCTION: Non-Communicable Diseases (NCDs) place a significant burden on India's healthcare system, accounting for approximately 62% of all deaths in the country in 2017. The southern Indian state - Kerala - has some of the highest rates of NCDs. Within the state, the fisherfolk community has a high prevalence of risk factors such as tobacco use and alcohol consumption. Working in the fisheries industry demands physical exertion, night shifts alongside extended periods of time at sea (for seafaring fisherfolk). Evidence is scant on how these conditions relate to the health-seeking experiences of fisherfolk, particularly in the context of NCDs. We conducted a qualitative study in two districts of Kerala to fill this gap.
METHODS: In-depth individual and small group interviews- as per participant preference -  with male and female fishing community members living with NCDs were conducted between October 2022 and February 2023 in two districts of Kerala. Interviews were conducted to explore community members' experiences with health-seeking for NCDs. Transliterated English transcripts were coded using ATLAS.ti software and analysed using thematic analysis with inductive generation of codes, with indexing against Levesque, Harris, and Russell's 2013 access to healthcare framework.
RESULTS: Thirty-three interviews with 42 participants were conducted. We found that NCDs were usually diagnosed late- either when admitted/consulted for other illnesses or when the symptoms became unbearable. Health-seeking patterns differed between seafaring and inland fishing subgroups, who were sampled from two districts in the state. Seafaring fisherfolk preferred public facilities for regular checkups and medicines while in-land fisherfolk relied on private facilities, although it was considered expensive. Ability to seek care was impacted by the working hours of the health centre which did not suit their working hours. Health constaints and related expenses also impacted their financial status and occupation, with some opting for less strenuous jobs.
CONCLUSION: This study highlights the NCD-related health-seeking experiences of the fisherfolk community in Kerala, India. Fisherfolk reported self neglect, delayed diagnosis, cost and livelihood constraints owing to the onset of NCDs, even as dual practice and medicine access in the public sector were appreciated. Overall, larger studies and policymaking processes should consider in depth the experiences faced by particular economic groups like fisherfolk, who may face unique health and care-seeking challenges.
In the control group (CG), a conventional physiotherapy program will be implemented for 2 weeks. A 10-session treatment will be completed using thermal and electrical agents specified in the program prescribed by the physiotherapist.
This invention makes use of 20 different amino acids, of which three contain sulphur, and the histidine : lysine : arginine ratio of 1 : 4 : 12 optimally promotes keratin synthesis. The substances present in garlic oil, such as alliin, allicin and methyl allyl trisulphide, and the Extrapon-5 special stop hair loss and promote hair growth. Extrapon-5 special is an extract from stinging nettles, coltsfoot, yarrow, rosemary, sage, horsetail, clover flowers and birch, enriched with a vitamin B complex. Nicotinic ester promotes blood flow. Phospholipids and the polyoxyethylene sorbitan oleate (Tween 80) promote the absorption through the scalp. The invention is based on the combination of 20 different amino acids, garlic oil, ethyl nicotinate, Extrapon-5 special and phospholipids in the combination stated in the patent as composition to counteract hair loss and promote hair growth.
Hepatocellular carcinoma (HCC) is a prevalent malignancy characterized by an exceedingly high recurrence rate post-surgery, significantly impairing the prognosis of HCC patients. However, a standard in-care strategy for postoperative therapy is still lacking. Although encouraging results have been obtained in a newly published clinical trial for postoperative therapy by targeting the vascular endothelial growth factor (VEGF) and programmed death ligand 1 (anti-PD-L1), its efficacy remains constrained. Combining a hemostatic hydrogel with a nanoparticle-based drug delivery system presents an opportunity to optimize the antitumor effect. Herein, we developed a nanoplatform, termed HMSN@Sor/aP@Gel, comprising a hemostatic fibrin hydrogel and functionalized hollow mesoporous silica nanoparticles (HMSNs) loaded with sorafenib and anti-PD-L1 for locally administered targeted-immunotherapy to prevent the postoperative recurrence and metastasis of HCC. The antitumor mechanism is grounded in dual inhibition of Ras/Raf/MEK/ERK (MAPK) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathways, synergistically complemented by PD-L1 blockade. HMSN@Sor/aP@Gel facilitates dendritic cell maturation, enhances cytotoxic T-lymphocyte infiltration, promotes the polarization of tumor-associated macrophages to M1 phenotype, induces tumor immunogenic cell death, reverses immunosuppression, and establishes immune memory to counter postoperative recurrence. Animal studies corroborate that HMSN@Sor/aP@Gel-mediated targeted immunotherapy significantly impedes primary and metastatic tumor growth and establishes immune memory to prevent recurrence post-surgery. This investigation presents a promising strategy for postoperative therapy with considerable potential for clinical translation.
A method and apparatus are provided for providing a forgotten bolus warning for an insulin pump user. User selections for mealtimes are received and stored. A user selection for a warning wait period is received and stored. When a time past a mealtime plus the user selection for the warning wait period is identified, checking for a bolus having been taken is performed. Responsive to no bolus having been taken, the user is alerted with the forgotten bolus warning. The user is alerted with the forgotten bolus warning by an audible, visual, or tactile warning for a programmable period of time. The user selections for mealtimes are received and stored on a daily basis for each day of the week. The user selection for a warning wait period can be received and stored independently for each meal.
Stroke is a leading cause of long-term disability and mortality worldwide, necessitating effective rehabilitation strategies for successful recovery. Traditional Chinese medicine (TCM) has gained recognition as a complementary and alternative approach in stroke rehabilitation, owing to its unique syndromes that offer valuable insights for personalized treatment plans. This study aims to elucidate the correlation between TCM syndromes observed during the recovery phase of stroke and the associated neurological deficits. Syndromes such as Blood stasis, Phlegm-dampness, Qi deficiency, and Yin deficiency were systematically examined, while standardized neurological assessments, encompassing motor function, sensory perception, and cognitive abilities, were employed to evaluate the extent of neurological impairment. Rigorous statistical analyses were conducted to discern potential correlations between TCM syndromes and the severity of neurological deficits. The results revealed statistically significant positive associations between certain TCM syndromes, particularly Blood stasis and Phlegm-dampness, and heightened neurological deficits during the recovery phase post-stroke. These findings suggest that these syndromes may serve as indicators of more severe brain injury post-stroke, thereby guiding the development of tailored rehabilitation strategies. By establishing robust connections between TCM syndromes and neurological deficits, this study contributes to advancing our understanding of stroke recovery through an integrated approach that incorporates TCM principles. Moreover, it underscores the potential benefits of integrating TCM into conventional rehabilitation protocols, offering valuable insights for healthcare professionals and potentially improving patient outcomes.
Provided are a compound indicated as formula (A-I), a coloring hardening resin composition including the compound, a color filter formed using the resin composition and a display including the color filter. In formula (A-I), X refers to an oxygen atom, a nitrogen atom or a sulfur atom. ′Y′^(m-) refers to any m-valent anion. R^41-R^46 independently refer to a hydrogen atom and an alkyl group having 1-20 carbons capable of being replaced with an amino group or a halogen atom. R^47-R^54 independently refer to a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, or an alkyl group having 1-8 carbons. R^55 refers to a hydrogen atom, an alkyl group having 1-20 carbons, or an aryl group capable of being replaced.
This is a single-center, open-label, single-arm study. A single drop of the ophthalmic solution will be instilled in each eye on the morning of Day 1 and then twice a day (in the morning and in the evening, approximately 12 hours apart) starting on Day 2 for 40 consecutive days (Days 2 to 41). Thereafter, a single drop of the ophthalmic solution will be instilled in each eye on the morning of Day 42, for a total of 82 consecutive doses administered in each eye. The doses of Days 1, 2 (morning), 41 (evening), and 42 will be self-administered under supervision of the site staff at the clinical site. All remaining doses will be self-administered at home. Throughout the study, PK blood samples will be collected and safety assessments will be performed.
The duration of study in Arm B will be 24 months, with study assessments and interventions (review of diet, food diary, and guidance from the dietician; review of activity journal, assessment of body composition, tests for gait, balance and muscle strength, and new assignment from the exercise trainer) done at baseline, 12 months, 15 months, 18 months and 24 months. At 12 months, participants in Arm B will be offered the same intervention that Arm A received during months 1-12.
In this study, a randomized control group pretest-posttest design was used to evaluate the effect of a health education program based on the health belief model and text messages on the level of knowledge, awareness and quality of life regarding cardiovascular disease risk factors in firefighters.

The power analysis was applied based on a 5% significance level (or 95% confidence interval), two-way, 80% power requirement. As a result of the analysis, the minimum sample size required for each group (intervention and control) in the study was calculated as 67 people. The intervention group received health education on prevention of cardiovascular disease risk factors based on the Health Belief Model consisting of 3 sessions. Following the health education, a total of 39 reminder text messages were sent via WhatsApp three or four times a week for 12 weeks to increase self-efficacy and health motivation. Data were collected through face-to-face interviews and by using the Cardiovascular Disease Risk Awareness Rating Scale, the Cardiovascular Disease Risk Factor Knowledge Level Scale and the EQ-5D Quality of Life Scale. In data analysis, dependent samples t test (paired samples t test) was used for intra-group mean comparisons and independent samples t test (independent samples t test) was used for inter-group mean comparisons.
Olaparib will be administered per os bi-daily, as appropriate assigned dose level, during 7.5 weeks (D1 to D52). Olaparib should be started one week before the start of radiotherapy and will be continued until the last day of radiotherapy. Beyond this period, Olaparib could be continued at the investigator's discretion and after sponsor authorization, until progression. Radiotherapy consists of fractionated focal irradiation at a dose of 1.8 Grays (Gy) per fraction given once daily five days per week (Monday through Friday) over a period of 6.5 weeks, for a total dose of 59.4 Gy. Radiotherapy starts at D8.
PROBLEM TO BE SOLVED: To obtain a readily handleable pharmaceutical composition useful for providing rapid solubility after oral administration by including menatrenone widely used for improving hemostatic functions in a specific carrier. SOLUTION: This pharmaceutical composition is prepared by including menatrenone in a carrier containing (a) en edible fatty oil in combination with (b) a surfactant selected from polyoxyethylene sorbitan monooleates, sorbitan sesquioleates and sucrose esters of fatty acids as a carrier therein. Beeswax or white beeswax and/or a fatty acid monoester of glycerol may further be added to the composition. Lecithin may further be contained therein. The amount of the edible fatty oil is 0.2-10 pts.wt. based on 1 pt.wt. menatrenone and the amount of the surfactant is 0.05-5 pts.wt. based on 1 pt.wt. menatrenone.
PURPOSE: To report three cases of facial nerve lesions that were clinically expected to be facial nerve tumors but showed fibrotic infiltration without any apparent signs of a specific tumor on histopathological findings. We also aimed to investigate the clinical characteristics of these cases.
METHODS: Medical records of patients who underwent surgery for facial nerve lesions were reviewed.
RESULTS: All three cases initially had House-Brackmann (HB) grade IV-V facial nerve palsy. On radiological imaging, schwannoma or glomus tumor originating from the facial nerve was suspected. All patients underwent complete surgical removal of the neoplasm followed by facial nerve reconstruction using the sural nerve. The lesions were histologically confirmed as infiltrative fibrous lesions without tumor cells. In two cases, facial nerve palsy improved to HB grade III by nine months post-surgery, and there were no signs of recurrence on follow-up MRI. The other case, after 1 year of follow-up, showed persistence of HB grade V facial nerve palsy without any evidence of recurrence.
CONCLUSION: Fibrotic lesions of the facial nerve could mimic primary facial nerve tumors. Clinicians should consider this condition even when a facial nerve tumor is suspected.
The importance of the proposed research project derives from a steady accumulation of research findings on the relationship between respiration and anxiety. The relationship between panic disorder and abnormalities in respiration has been recognized for more than 10 years. Increased sensitivity to CO2 exposure in panic disorder represents the most consistent finding supporting this relationship. The current proposal follows naturally from three sets of recent research findings in the area of panic disorder. First, our group has recently shown that children with anxiety disorders, like adults with panic disorder, exhibit increased sensitivity to CO2. Second, other researchers have shown that psychiatrically healthy relatives of patients with panic disorder also exhibit increased sensitvity to CO2. Finally, our group has also recently shown that children of adults with panic disorder exhibit high rates of anxiety disorders, particularly separation anxiety disorder, the childhood anxiety disorder which exhibits the highest degree of CO2 sensitivity. These three findings suggest that children of parents with panic disorder may exhibit a latent vulnerability to panic disorder, manifested as increased sensitivity to CO2.

A secondary feature of the proposed research project derives from a steady accumulation of research findings in basic science literature outlining the parts of the brain that mediate fear and anxiety in animals. It may be possible to use insights from research on the brain basis of fear in animals to develop methods for assessing the brain basis of fear in humans. Moreover, work in animals notes changes in brain systems that mediate fear and anxiety across development. If developmentally sensitive methods could be used to study fear in children, it may also be possible to greatly enhance our understanding of the manner in which the relationship between brain function and fear changes as children age. If similarities could be demonstrated across animals and humans in these areas, new insights on potential treatments for anxiety could be more readily transferred from the laboratory to the clinic. A second goal of the current proposal is to refine two neuropsychological probes that are thought to assess functional aspects of brain systems implicated in fear and anxiety across various species, from rodents to humans.
<P>PROBLEM TO BE SOLVED: To provide a new dosage form for administering a drug through the eyelid skin and provide an external preparation giving a prodrug taking consideration of the action of enzymes in the skin.  <P>SOLUTION: A drug to be transferred from the outer surface of the eyelid skin to a topical region is converted to a prodrug (e.g. an ester) and dissolved (or suspended) in a base (e.g. water, an alcohol, etc.). The substance can be used as an external preparation as it is, however, it is preferable to hold the substance on a holding material such as tape or poultice and apply to the eyelid skin.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The invention relates to a preparation method of a traditional Chinese medicine for treating hypochondriac pain caused by dampness-heat of liver and gallbladder, which belongs to the traditional Chinese medicine preparation method technical field. Currently, the treatment for treating hypochondriac pain caused by dampness-heat of liver and gallbladder generally employs morphine hydrochloride, and the disadvantage of the morphine hydrochloride is vertigo, nausea, vomit, palpitaition, constipation, sweating, dysuresia and respiratory depression, continuous administration can easily lead to addiction, and locus ceruleus has direct connection with morphine hydrochloride addiction abstention action. A technical scheme is characterized in that root of large-flowered skullcap, coptis, phellodendron, Broomjutre Sida Herb, Ilextrotunda thumb, radices stellariae dichotomae, creeping oxalis, sandalwood, Veronicastrum Herb, Daghestan sweet clover Herb, aspongopus, sword bean, elecampane, szechwan Chinaberry fruit, caesalpinia sepiaria, combined spicebush, Nardostachyos Root and Rhizome, ambergris, curcuma tuber, Valeriana jatamansi jones and licorice are taken, the above 21 traditional Chinese medicines are placed in water for immersing, and then decocted by slow fire, wherein the decocted soup is the traditional Chinese medicine for treating hypochondriac pain caused by dampness-heat of liver and gallbladder. The prepared traditional Chinese medicine soup has the advantages of small toxic and side effects, short treatment course and high cure rate. Different raw materials have different functions, and combination of the raw materials is proper and right. When the traditional Chinese medicine is applied, the adverse reaction, anaphylactic reaction and toxic response of western medicine sulfanilamide and antibiotics can be simultaneously avoided.
PURPOSE: To separate a blood phase efficiently by providing the stopper of a rotor which stops the free rotation of a tube holder at a second position where the axis of a test tube agrees nearly with the radius of the rotor, and a complete gel seal is formed in the tube. CONSTITUTION: The substrate 32 of a holder 30 is fitted freely rotatably to a rotor 22, and all tubes T extend from the rotating end part 42 to the outside in the radius direction toward the opposite end part 44 of the substrate 32. Preferably, a stopper 46 is installed, the holder 30 is fitted at a position AA, and the axis 50 of the tube is non-aligned by an angle α to all the radii of the rotor 22, e.g. a radius 52. The tubes T and the tube holder 30 are held at the position AA by a fitting tool 60 which is fixed to the rotor 22 and actuates on a projection part extending from the rotor 22. It is rotated at an enough speed to separate the phase of all blood in the tubes T, and the phase separation is accelerated by the Boycott effect since the angle α is not zero.
Tumor tissue samples undergo genotype assessment on the Pyrosequencing platform. Contingency tables and X\^2 test performs a univariate analysis of the risk of relapse and genotype, and multivariable analyses using logistic regression. Cox proportional hazards evaluate the risk of relapse given genotype and other confounders. Genotype patterning, classification and regression trees, and multifactor dimensionality reduction evaluates for patterns of single nucleotide polymorphisms associated with toxicity and relapse risk.
Therapy with a GLP-1 RA with proven cardiovascular benefit. This means either dulaglutide, liraglutide, or semaglutide.
The first 3 patients will be injected at a dose of 0.5 mg/kg. If no or minimal activity is observed and no serious adverse events occur, the subsequent three patients will be injected with the second tier dose level of 1.0 mg/kg. If no or minimal activity is observed in in the second tier dosing group, and no serious adverse events occur, the following three patients will have the third tier dose of 1.5 mg/kg administered. An additional 2 patients will be recruited at the dose level that produces optimal LUM015 activity. All surgical specimens will be sent to the pathology suite for imaging with the LUM 2.6 Imaging Device and routine diagnostic assessment.