anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Glioma is a common kind of tumor in central nervous system. The pre-operative prediction of grade, histopathologic type and genotype is important for treatment and management of Adult diffuse Glioma patients. Right now, most of the diagnostic prediction models on glioma are based on 2016 WHO central nervous system tumor guideline. The goal of this study is to establish a new deep learning model to predict Grade, histopathologic type and genotype of adult diffuse Glioma. We will recruit 500 patients with pathologically confirmed diagnosis of Glioblastoma, Astrocytoma and Oligodendroglioma who received neurologic surgery in our center. Each subject underwent pre-operative multi-parametric magnetic resonance imaging scans including T1WI, T2WI, T1CE, FLAIR and DWI. Pathologic diagnosis of each patient are available in pathology department. A deep learning based hierarchical diagnosis
: The study was approved by the Institutional Review board of the Catholic University of the Sacred Hearth, Rome, Italy (prot. n. 17048/23). All adult patients with class I and II malocclusion referred to the Fondazione Policlinico Universitario Agostino Gemelli will be consecutively enrolled for this study. All patients will be treated with Biomax Nuvola aligners built based on the individual patient's characteristics. The number of aligners and the number/ type of attachments will be chosen on the basis of the individual malocclusions.

Patients will be randomly allocated in two different groups: the study group includes patients following the delayed protocol (DP), while the control group is composed of patients' following the conventional protocol (CP). The aligner will be changed every 15 days, so the attachment placement in the DP will be performed around 30 days from the beginning of the clear aligner treatment. The modified OHIP Italian version has 20 questions categorized into 7 sections, concerning the limitation generated by deterioration of oral health in relation to clear aligners: functional, pain, psychological discomfort, physical or psychological or social disability, and handicap. The answers range from 0 (never) to 4 (very often). Possible categories are: never (0), rarely (1), sometimes (2), habitually (3), and very often (4). Low scores indicate better self-perception of quality of life. The customised questionnaire has 9 questions, concerning the limitation generated by discomfort caused by attachments. For 8 questions, the answers range from 0 (never) to 4 (very often). Possible categories are: never (0), rarely (1), sometimes (2), habitually (3), and very often (4). Low scores indicate better self-perception of quality of life. For the last question the answer is based on NRS scale, in fact it ranges from 0 to 10. Lower score indicates less pain perceived by the patient. The questionnaires will be filled out at different phases of orthodontic treatment, specifically: at the delivery of the first aligner, after 3 and 7 days; at the delivery of the third aligner, after 3 and 7 days. The survey scheduling is arranged according to White, who stated that the patients' perception of pain and discomfort occurred within 7 days after the beginning of the orthodontic treatment; then, patients' quality of life tends to return to a baseline condition.

The study will be single-blind, because the person collecting the results and making the assessments will not know which treatment was used. In fact, the patient will anonymously submit the answers to the questionnaires uploaded on Microsoft Form, using an acronym that will be provided to him/her by the clinical operator. In this way, the person collecting and analysing the data will not know to which group the patient who sent the answers belongs.
Participants received talimogene laherparepvec at an initial dose of up to 4 mL 10⁶ PFU/mL by intralesional injection on day 1. Subsequent doses of talimogene laherparepvec at 10⁸ PFU/mL (up to 4 mL) began 3 weeks after the first dose and were administered every 2 weeks until the fifth injection of talimogene laherparepvec (week 9), and then synchronously with pembrolizumab thereafter every 3 weeks until disappearance of injectable lesions, iCR, confirmed iPD per modified irRC-RECIST, intolerance of study treatment, 24 months from the date of the first dose of talimogene laherparepvec, or end of study, whichever occurred first. Participants also received 200 mg pembrolizumab administered intravenously every 3 weeks starting on day 1 of week 0, until confirmed iPD per modified irRC-RECIST, treatment intolerance, 24 months from the first dose, or end of study, whichever occurred first.
Cross-over, double dummy, randomized, clinical trial was carried out. The sample size was calculated using the formula for clinical trials of mean differences with an "n" of 6 patients per group was obtained. Patients between 30 and 65 years of age will be included with T2DM, without hyperglycemic drugs, hemoglobin A1c (A1C) 6.5 to 11.0 % and with written signature consent. They were assigned randomly by sealed envelope either to received insulin Degludec (Novo Nordisk A/S. Bagsvaerd, Denmark) or insulin Glargine (Sanofi-Aventis Deutschland GmbH. Frankfurt, Germany) \[10 international units (IU) subcutaneous (SC) every 24 hours for six days\], patients who were administered initially insulin Degludec corresponded then insulin Glargine and vice versa, with a washout period of 14 days between each intervention.

The clinical findings and laboratory tests included a metabolic profile and biosafety, which will be made at baseline. Body weight, body mass index and blood pressure were performed during the initial visit, likewise, interstitial glucose concentrations by ambulatory continuous glucose monitoring system (Guardian®, Medtronic MiniMed, Northridge), through which the mean amplitude of glucose excursions (MAGE) and area under the curve of glucose were calculated, which served to assess the glycemic variability. Adverse events and adherence to treatment are documented. Statistical analysis: Mann-Whitney U test, Chi2, Fisher exact test. It is considered with significance at p \<0.05.
Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask ventilation and they do not alter mask ventilation. Thus, growing evidence suggests to administer muscle relaxants before testing mask ventilation.We will administer rocuronium 0.3 mg/kg, 0.6 mg/kg, 0.9 mg/kg and saline (placebo group) before starting with mask ventilation. We will grade mask ventilation based on various scores before and after rocuronium application. Afterwards patient's tracheas will be intubated. We assess risk factors for difficult mask ventilation.

We hypothesize that rocuronium 0.9 mg/kg will be superior to rocuronium 0.3 mg/kg and saline.
Melanocytic nevi can show a great number of morphological, cytoarchitectural, and stromal variations. Some of these histopathological patterns, infrequent or unusual, can occasionally produce diagnostic doubts or problems. A 22-year-old female patient presented a poorly pigmented cutaneous polypoid lesion of the scalp. Histopathological examination showed an intradermal melanocytic nevus composed of aggregates, nests, and cords of benign melanocytes, with collagenous stroma and large lipomatous areas. In the lipidized portion of the lesion, nevus cells, arranged in clusters, nests, and cords, were intimately associated with mature-appearing adipocytes, CD34-positive spindle cells, Alcian Blue-positive fibromyxoid stroma, and eosinophilic collagen bundles, findings resembling those typically seen in spindle cell lipoma. Spindle cell lipomatous metaplasia, rarely observed in some benign nonmelanocytic skin lesions, can be considered an additional unusual, not previously described, stromal variation occurring in melanocytic nevi.
1453198 Phenolic disinfectant composition COALITE & CHEMICAL PRODUCTS Ltd 21 Jan 1974 [23 Jan 1973] 3435/73 Heading A5E A disinfectant composition comprises an aqueous solution of a phenolic component and a surface active component, the phenolic component comprising one or more alkylphenols together with one or both of an aralkyl halophenol and an arylphenol and the surface active component comprising an anionic non- soap surface active agent which is one or more of a secondary alcohol sulphate, a salt of a sulphate of a C 8 -C 18  fatty alcohol ethoxylate and an alkaryl sulphonate. The composition remains clear on dilution with tap water. Typical components are xylenols (e.g. from a tar acid fraction), o-benzyl-p-chlorophenol, ophenyl phenol, sodium lauryl ether sulphate and sodium dodecylbenzene sulphonate. Optional ingredients are soaps (e.g. castor oil soap), and water-miscible alcohols such as isopropanol and methylated spirit.
Session 1 - Detailed history and examination, introduction to acupuncture. Sessions 2 - 10 - Each session will begin with insertion and manipulation of needles, which will remain in place for 30 minutes.
INTRODUCTION: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A "eraser", is responsible for decreased m6A modification. However, its role in cardiac fibroblasts during the post-myocardial infarction (MI) healing process remains elusive.
OBJECTIVES: To investigate the effect of ALKBH5 in cardiac fibroblasts during infarct repair.
METHODS: MI was mimicked by permanent left anterior descending artery ligation in global ALKBH5-knockout, ALKBH5-knockin, and fibroblast-specific ALKBH5-knockout mice to study the function of ALKBH5 during post-MI collagen repair. Methylated RNA immunoprecipitation sequencing was performed to explore potential ALKBH5 targets.
RESULTS: Dramatic alterations in ALKBH5 expression were observed during the early stages post-MI and in hypoxic fibroblasts. Global ALKBH5 knockin reduced infarct size and ameliorated cardiac function after MI. The global and fibroblast-specific ALKBH5-knockout mice both exhibited low survival rates along with poor collagen repair, impaired cardiac function, and cardiac rupture. Both in vivo and in vitro ALKBH5 loss resulted in impaired fibroblast activation and decreased collagen deposition. Additionally, hypoxia, but not TGF-β1 or Ang II, upregulated ALKBH5 expression in myofibroblasts by HIF-1α-dependent transcriptional regulation. Mechanistically, ALKBH5 promoted the stability of ErbB4 mRNA and the degradation of ST14 mRNA via m6A demethylation. Fibroblast-specific ErbB4 overexpression ameliorated the impaired fibroblast-to-myofibroblast transformation and poor post-MI repair due to ALKBH5 knockout.
CONCLUSION: Fibroblast ALKBH5 positively regulates post-MI healing by stabilization of ErbB4 mRNA in an m6A-dependent manner. ALKBH5/ErbB4 might be potential therapeutic targets for post-MI cardiac rupture.
A set of coupled computerized systems with methods that can allow a health care practitioner preferably to track clinical data about a patient, to link diagnostic and procedural code charges at the point of care, and to exchange such data with clinicians responsible for the cross-coverage of management responsibilities. Data may be captured on handheld computer devices (or directly by an Internet or client application) and transmitted to a coupled web server which warehouses and distributes data elements to the billing office of the practitioner. The web server may provide additional functionality for moving patient data, such as demographic, medication, and evaluation records, between office-based computer systems and the handheld. Hospital-managed data systems with Internet viewing permissions may also be queried for web server-effectuated transfer of patient data to the handheld device to augment clinical care and charge capture. Identifier-free data may be aggregated across multiple health care practitioners participating in the system, so that their administrative and clinical performance may be compared to others of the same specialty or in the same geographic region. Data on and between platforms may be encrypted and an audit trail may be generated in compliance with federal standards.
For bi-hemispheric stimulation, the anode will be placed at the intersection of F7 and FC5 and the cathode will be placed at the intersection of F8 and FC6. For all stimulations, the stimulation will be increased for 15 seconds at a dosage of 1 mA (milliampere) for the entire 20 minute session duration and decreased for 15 seconds at the end of the stimulation.
FIELD: medicine, nutrition. SUBSTANCE: invention relates to foodstuffs that are used in the case of impossibility or insufficiency of nutrition by natural way, in part, for enteral nutrition. Composite of the balanced mixture for enteral nutrition comprises dry cream, curd cryopowder, peanut cryopowder, wild rose cryopowder, carrot cryopowder, beet cryopowder, wheat germinated seedlings cryopowder, potato cryopowder, apple cryopowder and sugar. The combination of components taken in the definite ratio and the balance of proteins, lipids and carbohydrates allows to balance of trace elements calcium, magnesium and phosphorus also and to balance with regards to ratio of proteins and lipids of animal and vegetable origin in optimal ratio of non-protein calories, nitrogen and osmolarity. EFFECT: valuable properties of mixture. 4 cl, 3 tbl
A transform-based X-ray chest radiography automatic diagnosis and new crown infected area segmentation method belongs to the field of image processing. The network consists of three parts, namely a double-path embedded layer, a Transformer module and an image segmentation decoder. The double-path embedding layer encodes image features in two modes, namely a two-dimensional convolution and the front four layers of a ResNet34 network, and outputs shallow visual features and deep abstract features of the X-ray chest film respectively. The Transformer module is the core of the whole network, and the network comprehensively considers the local characteristics and the global characteristics of the pictures, the deep abstract characteristics and the shallow high-level characteristics. The segmentation decoder is used for outputting segmentation results of the new coronary lung infected area. The network uses a loss of uncertainty to dynamically balance the classification and segmentation tasks. The classification loss function is the sum of a classification contrast loss function and a cross-entropy loss, and the segmentation loss uses the cross-entropy loss of the two classes.
VLX-1005 is being developed as a treatment for heparin induced thrombocytopenia (HIT), a rare but life threatening illness. Currently, the anticoagulant argatroban remains the standard of care for treating HIT. However, this treatment remains inadequate due to both thrombosis and major bleeding complications that each may exceed 30% of treated HIT patients. These findings are significant to the later stage clinical development of VLX-1005 as a trial of VLX-1005 on top of argatroban therapy would require an understanding of any potential drug-drug interactions- whether direct or via metabolism. Specifically, coadministration of VLX-1005 with argatroban mandates an analysis of the potential effects on PK, pharmacodynamics and bleeding. The current study is designed to address these important questions.
Embodiments relate to non-invasively determining coronary circulation parameters during a rest state and a hyperemic state for a patient. The blood flow in the coronary arteries during a hyperemic state provides a functional assessment of the patient's coronary vessel tree. Imaging techniques are used to obtain an anatomical model of the patient's coronary tree. Rest boundary conditions are computed based on non-invasive measurements taken at a rest state, and estimated hyperemic boundary conditions are computed. A feedback control system performs a simulation matching the rest state utilizing a model based on the anatomical model and a plurality of controllers, each controller relating to respective output variables of the coronary tree. The model parameters are adjusted for the output variables to be in agreement with the rest state measurements, and the hyperemic boundary conditions are accordingly adjusted. The hyperemic boundary conditions are used to compute coronary flow and coronary pressure variables.
Mental health problems in adolescents reflect a global problem that is becoming more prevalent in Hong Kong. In Hong Kong, there is a significant change in family structure to small nuclear families. Children receive more attention and may even be overprotected by parents. Also, parents' great expectations for high academic achievement also contribute to the increase in mental health problems among adolescents in Hong Kong. The Polytechnic University and the Christian Family Service Centre conducted a mental health survey study of 12,518 Form 1 to Form 7 pupils from 2011 to 2014. Of the respondents, 62.1% demonstrated slight to very serious depression symptoms. Evidence has shown that depressive symptoms predict suicidal tendencies among adolescents.

Resilience effectively prevents the development of mental health problems and is associated with positive mental health outcomes in adolescents. Assessing resilience in adolescents is therefore crucial for developing a thorough understanding of their responses to stress and adversity. The literature reports various instruments used to assess resilience, such as the Connor-Davidson Resilience Scale (CD-RISC) and the Resilience Scale (RS). And translated version of RS-14 is also developed because of linguistic and cultural differences.

The proposed study will aim to translate the original RS-14 (English version) into traditional Chinese. It will then test the psychometric properties of the newly translated RS-14 to examine its factorial structure using both exploratory factor analysis (EFA) and CFA. Furthermore, using the newly validated RS-14, a survey will be conducted to assess the resilience level of a large sample group of Hong Kong Chinese adolescents.
For the first 6 weeks, subjects will consume their habitual diet. For the second 6 weeks, subjects will receive the anti-inflammatory diet.
The blood supply to the distal part of the arm will be occluded by inflation of a single cuff to 200mmHg, by the help of the Single Cuff Tourniquet 8000, for 5 minutes separated from 5 minutes of deflation, a cycle that happens 4 times in total. The ischemic reperfusion injury was induced by cuff inflation to 200 mmHg in the arm for 20 minutes followed by reperfusion for 15 minutes.
OBJECTIVE: Phacoemulsification is the predominant method for cataract surgery, but complications like lens nuclei dislodgment into the vitreous cavity pose significant risks, including inflammation, glaucoma, retinal tears, and vision loss. Traditional management involves pars plana vitrectomy with phacofragmentation, which can increase the risk of retinal damage due to repulsive forces. This study tests whether the OZil phacoemulsification handpiece, employing torsional movement, offers a safer alternative by minimizing repulsive forces and reducing surgical duration compared to the traditional phacofragmatome.
METHODS: This prospective study, conducted in a tertiary care hospital in eastern India from January to June 2023, enrolled 40 patients with nucleus dislocation during cataract surgery. Patients were randomized into Group 1 (traditional phacofragmatome) and Group 2 (OZil handpiece). Primary objectives included comparing the duration of surgery and intraoperative complications. Secondary objectives assessed postoperative best-corrected visual acuity (BCVA), surgical site safety, and cystoid macular edema (CME) incidence.
RESULTS: Group 2 demonstrated significantly shorter surgical durations (110±2.54 seconds) compared to Group 1 (152±2.23 seconds, p < 0.001). The frequency of nucleus falls was considerably lower in Group 2 (p < 0.001). Postoperative BCVA and CME incidence showed no significant differences between groups. Multiple regression analysis confirmed the OZil handpiece significantly reduced surgical duration (β = -0.40, p < 0.001) without compromising safety.
DISCUSSION: The OZil handpiece's rotational cutting mechanism offers a significant advantage in reducing surgical time while improving the followability of lens fragments, as compared to the traditional phacofragmatome. It addresses one of the key limitations of phacofragmentation by minimizing fragment displacement, where repulsive forces can complicate the procedure. Although both techniques showed similar safety profiles, the OZil handpiece's operational efficiency makes it a promising alternative for managing posteriorly displaced lens fragments in complex cases.
CONCLUSIONS: The OZil phacoemulsification handpiece significantly enhances surgical efficiency and safety in nucleus drop surgeries. Its integration into existing phacofragmatome systems can lead to major advancement in the ophthalmic surgical armamentarium, ensuring improved patient care.
A method of treating or preventing sea louse infections, especially in fish farms, by applying a non fungal microbiological control agent is claimed. The microbiological agent may be a protozoan, bacterium or virus. Preferably the sea louse species is either <I>Lepeophtheirus salmonis</I> or <I>Caligus elongatus</I>. Also claimed are sea louse cell lines, culture or bioreactor systems for the production of viruses. The use of coelomic fluid from crustaceans as a supplement for these cell lines is also claimed. Screening of sea lice or sea louse extracts for biological control agents is also claimed as is the use of such agents in medicine.
Patients treated with 3 sessions of 1064nm Nd: YAG laser at 4-weekly intervals. Results are compared with baseline.
A novel standardized liquid propolis extract and pharmaceutical formulation based on said extract, as well as their manufacturing methods and uses, are provided. The liquid extract is produced by extraction of crude propolis with an extraction solvent based on a mixture of PEG 200-600 (96.5-99.9% w/w) and lecithins (0.1-3.5% w/w). The extract is characterized with standardized content of p-coumaric acid (1), trans-ferulic acid (2), caffeic acid (3), and CAPE (4). It is used as an active ingredient in manufacturing of pharmaceutical, cosmetic, veterinary, agrochemical or functional food products. The pharmaceutical formulation according to the invention consists of 5-95% w/w of the said propolis extract and up to 100% excipients required for preparation of various dosage forms. It is used for treatment of diseases and conditions in humans and animals such as: inflammatory diseases, bacterial and fungal infections, viral, autoimmune and cancer diseases, and for the treatment of burns and wound healing.
The process comprises dissolving the raw insulin, after removal of alcohol from cattle or pig pancreas processing, in hydroacetone buffer soln. of ammonium acetate (pH = 6.1). Pptn. in the presence of zinc ions, for dissolving at acid pH and reprecipitation of alkaline pH in the presence of NaCl, EDTA and zinc ions, is followed by redissolving at acid pH and reprecipitation by addn. of NaCl. The insulin is crystallised to min. 24 UI/mg purity.