anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: The role of suppressor of cytokine signaling (SOCS)2 in anti-infective bacterial immunity has been poorly investigated compared to other members of the SOCS family.
METHODS: We characterized the previously identified loss of function R96C point mutation of SOCS2 using a genome-edited mouse model that resumes the phenotype of Socs2 knockout mice. The response of macrophages to TLR-ligands and Staphylococcus aureus was examined.
RESULTS AND DISCUSSION: Conversely to previously published data using human monocyte-derived macrophages, the stimulation of bone-marrow-derived macrophages with various TLR ligands did not show any difference according to the SOCS2 variant. Upregulation of IL-6 and TNF-α pro-inflammatory cytokines production was only seen when the SOCS2 expression was promoted by the culture of macrophages in the presence of GM-CSF. Furthermore, we showed that the SOCS2 point mutation is associated with heightened STAT5 phosphorylation in a short time frame upon GM-CSF incubation. In mice, recruitment of neutrophil and F4/80int Ly6C+ inflammatory macrophage, as well as IFN-γ and IL-10 concentrations, are significantly increased upon S. aureus peritoneal infection. Altogether, these data support the idea that by lowering the pro-inflammatory environment, SOCS2 favors better control of bacterial burden during a systemic infection caused by S. aureus.
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a toad oil composition for relieving cough and asthma, a traditional Chinese medicine composition, and a preparation method and application thereof. The oviductus Ranae composition is prepared from raw materials of forest frog oil, chinese forest frog skin, loquat leaf and liquorice. The traditional Chinese medicine composition is prepared into drug-loaded liposome by wrapping the oviductus ranae composition with soybean lecithin, cholesterol and cationic materials. The drug-loaded liposome has the effects of moistening lung and relieving cough, can relieve dry cough and asthma, and particularly has obvious relieving effect on cough caused by consumptive disease; can improve cough, expectoration, etc. caused by chronic bronchitis. The liposome preparation prepared by the invention is administered by pulmonary inhalation administration, has quick response, makes up for the blank of the administration of the oviductus Ranae aerosol, is matched with an atomizer for use, is convenient and safe, has high bioavailability, improves the conditions that the oviductus Ranae is difficult to absorb and easy to grease in the use process, has no adverse reaction, and is suitable for a wide range of people.
Rapamycin treatment was initiated with a loading dose of 6 mg by mouth on day 1 followed by 2 mg by mouth daily. The dose was then adjusted to maintain a target blood level of 3-9 ng/ml for the first 16 weeks. After week 16, the dose of Rapamycin was increased to a target level of 9-15 ng/ml unless there was evidence for a partial response or complete response by kidney MRI. Trough Rapamycin levels were checked every 8-12 weeks (at 24 weeks, 32 weeks, 40 weeks, and 52 weeks) in all patients until the 12-month (week 52) study visit. If the Rapamycin dose was below target, the dose was increased by 1-2 mg until the target trough level was achieved. Rapamycin levels were checked every 2-3 weeks while the dose was adjusted. Amendment 20 (Jan 2009) permitted additional Rapamycin treatment during months 12-24 if the treating site investigator judged that this was in the best interest of the study participant.
The right colon diverticula, unlike those in the left colon, contain all layers of the colon and is called the true diverticulum. Perforation is observed less frequently due to its full thickness. Conservative treatment can be applied unless complications such as abscess formation and free perforation occur. Here, we aimed to discuss the results of conservative and surgical treatment for right colon diverticulitis in the light of the literature. 150 patients treated for colon diverticulitis between 2015-2020 were retrospectively screened. Right colon diverticulitis detected incidentally, missing data, and left colon diverticulitis were excluded from the study. Data of a total of 26 patients were accessed. Unlike the left, right colon diverticulitis has low complications and can be treated conservatively. The differential diagnosis of right colon diverticulitis should be kept in mind in order to prevent unnecessary surgeries. Surgical treatment is inevitable in cases such as recurrent diverticulitis, generalized peritonitis, and suspected malignancy
The invention discloses a nucleotide sequence used in the preparation of the Mycobacterium smegmatis vaccine and an application thereof. The nucleotide sequence of the natural Mycobacterium smegmatis MPT64 gene is optimized by adopting the codon preferred by human, and a gene synthesizer is utilized to synthesize the optimized sequence (MPT64A). The optimized MPT64A gene is cloned to eukaryotic expression vector pcDNA3.1(+) or to adenovirus vector pAd. The constructed pcDNA3.1(+)-MPT64A DNA vaccine or pAd-MPT64A recombinant adenovirus vaccine is utilized to immunize the BALB/c mice. The indirect ELISA experiment and the lymphocyte proliferation experiment are adopted to detect the immune effect of the vaccine and prove that the vaccine has good immunogenicity in the BALB/c mice. In the preparation of the nucleotide sequence, the simple and quick method is adopted to modify the Mycobacterium smegmatis MPT64 gene to ensure that human body has the optimized gene with higher immune effect, thus better antigen genes can be provided for the development of the Mycobacterium smegmatis vaccine.
Subjects with ADA-SCID who have received Strimvelis (previously GSK2696273) gene therapy, comprising patients treated prior to marketing authorisation (i.e. clinical studies and compassionate use programs) and those treated after marketing authorisation (including within compassionate use and early access programs).
A contact and ranging system includes a first device that includes a first transceiver, a second transceiver, and a controller to control the first transceiver and the second transceiver of the first device. The first device is operable to determine a distance between the first device and a second device. The first transceiver is configured to perform a discovery operation. Other devices are discovered and added to a list of paired devices. A ranging schedule for each paired device in the list of paired devices is determined. The second transceiver is configured to perform a ranging operation. The ranging and response transmissions are transmitted and received by a pair of devices, such that a range between the pair of devices is determined based upon a time of flight between the pair of devices. The range between the pair of devices is matched with a timestamp and stored in a database.
HBED-PSMA Sterile Cold Kit is a kit for preparation of radiolabelled 68Ga-PSMA-11. After radiolabelling with a 68Ga chloride solution complying with the requirements of monograph 2464 of the European Pharmacopoeia (Ph Eur), the solution may be used in men with biochemical relapse of prostate cancer after treatment. A large number of studies have been published on 68Ga-PSMA-ligands but none has yet been conducted with a product manufactured in accordance with ANMI technology. The aim of the study is to demonstrate the superiority of 68Ga-PSMA-11, prepared from a room temperature radiolabel kit containing PSMA-11 (PSMA-11 Sterile Cold Kit) and gallium 68 obtained from a 68Ge / 68Ga generator on 18F-Fluorocholine (18F-FCH) in identifying prostate cancer recurrence after radical treatment sites. So, patients will be evaluated with the current workup at CHRU of Nancy and will then be submitted to 68GA-PSMA-11 and 18F-FCH imaging. Patients will be randomized to the imaging procedure after workup in a 1/1 ratio between 68GA-PSMA-11 and comparator. So all patients will be submitted to 68GA-PSMA-11 and 18F-FCH; 50% of patients will receive the 68GA-PSMA-11 first; 50% of patients will receive the comparator first. There will be a time interval of minimum 7 days and maximum 14 days between both imaging procedures.

In order to mimic, as far as possible, the routine clinical practices, a sequential unblinding will be used for image readers. Readers will evaluate 68GA-PSMA-11 and 18F-FCH images with progressive access to more clinical information on each read. It will be done in three steps: fully blinded image evaluation, then image evaluation with results of the patient's clinical history and finally image evaluation with results of the patient's workup and clinical history.
All enrolled patients will receive intravenous infusion of durvalumab 1500 mg on day 1 (induction phase) with carboplatin (AUC 5 on day 1), etoposide (100 mg/sqm on days 1-3) every 3 weeks, and durvalumab (1500 mg on day 1) administered every three weeks for up to 4 cycles (induction phase) or until progression of disease, unacceptable toxicity, patient refusal or loss of clinical benefit (for durvalumab). Treatment with intravenous durvalumab (1500 mg on day 1) every 4 weeks ± 3 days (maintenance phase) will continue until completion of 24 courses (for a total of 28 courses, including the 4 courses of induction phase) or 2 years of treatment whichever occurs first, disease progression, unacceptable toxicity, patient refusal or loss of clinical benefit.
Participants received MMF, 1.5 to 2.0 g daily, PO, BID from BL to Week 52. Participants also received a 75% reduced dose of CNI from BL to Week 52.
Currently, there is still no uniform treatment regimen in treating recurrent or metastatic nasopharyngeal carcinoma patients who failed to first-line platinum-based chemotherapy. Anti-PD-1 monoclonal antibody showed efficacy and safety in previous studies, however, the efficacy of immunotherapy alone was limited. Immunotherapy combined with other treatment regimens for recurrent or metastatic nasopharyngeal carcinoma is a strategy that needs to be urgently explored. Vascular endothelial growth factor (VEGF) is an important target in the treatment of nasopharyngeal carcinoma. Apatinib, a small-molecule tyrosine kinase inhibitor selectively inhibits vascular endothelial growth factor receptor 2 (VEGFR-2), has shown strong clinical utility. Previous clinical studies have confirmed that apatinib shows antitumor activity and tolerable toxicity in recurrent or metastatic nasopharyngeal carcinoma. Tumor vascular normalization and immune reprogramming interact synergistically and could enter a mutually reinforcing virtuous cycle by improving tumor microenvironment. The current national comprehensive cancer network (NCCN) guidelines also recommend Nivolumab and Pembrolizumab as second-line treatment for recurrent or metastatic nasopharyngeal carcinoma. More and more evidences show that immunotherapy combined with anti-angiogenesis therapy has a synergistic effect, and Camrelizumab combined with apatinib has achieved initial effect in solid tumors. Based on this, this study aims to evaluate the efficacy and safety of Camrelizumab combined with apatinib in the patients with recurrent or metastatic nasopharyngeal carcinoma who failed to first-line anti-PD-1 monoclonal antibody, to provide new evidence for individualized comprehensive treatment in nasopharyngeal carcinoma.
The present invention provides a traditional Chinese medicinal composition for retained afterbirth and retention of dead fetus of livestock. The traditional Chinese medicinal composition consists of the following raw materials by weight: 8-50 parts of pangolin, 6-50 parts of peking euphorbia, 12-50 parts of talcum and 10-30 parts of Lygodium japonicum. The invention also provides a preparation method of the composition. The traditional Chinese medicine composition has the advantages of reasonable componenta, simple preparation process, convenient material drawing, low cost, no drug residues, no toxic or side effect, easy absorption and high cure rate. The composition has substantial treatment effect on retained afterbirth and retention of dead fetus of livestock. Through test, the traditional Chinese medicinal composition has cure rate of above 93% in the treatment of retained afterbirth and retention of dead fetus of livestock.
This prospective hospital based open label interventional study will be conducted in Dhaka Medical College Hospital, Dhaka after receiving approval of this protocol from ethical review committee of DMC. Patients who match the inclusion and exclusion criteria will be enrolled in the study by simple random sampling. A written informed consent will be taken from patients or from their legal attendants after describing the aim, purpose and procedure of the study. Focal epilepsy will be diagnosed according to the criteria of the Commission on Classification and Terminology of the International League against Epilepsy (2017). In this study patients will be divided into 2 groups on their antiepileptic medication. The screening procedure, randomization and drugs will be started at day 1. All the assessment will be completed at day 1 and will be considered as baseline. Randomization will be done at 1:1 into parallel group. Each group will include 34 patients. Group A will include focal epileptic patients on lamotrigine and group B will include focal epileptic patients on carbamazepine. A structured questionnaire will be completed by investigator from answers of participating patients or with the help of their legal attendants, to obtain information on demographic characteristics (age, gender, marital status, education, socioeconomic level etc) and outcome of drug intervention. The patients will maintain a diary during the whole period and ask to note down any seizure frequency with date, time, duration and adverse effects of drugs. During the data record keeping every patient will be evaluated initially by investigator and later independently evaluated by a consultant neurologist.

Lamotrigine will be given at starting dose 25 mg once daily for 2 weeks, then 50 mg once daily for next 2 weeks and carbamazepine will be given at starting dose 100 mg twice daily for 2 weeks, then 200 mg twice daily for next 2 weeks. In both drugs dose will be increased until seizure control or side effects develop.

Patients will be followed up at 1st month, 3rd month and 6th month after receiving medication and following outcome will be assessed: reduction of seizure frequency, seizure free period, hospital readmission, frequency of status epilepticus, all-cause mortality, adverse drug reactions. Patients will be followed up at epilepsy clinic / outpatient department (OPD) and those patients who fail to attend at epilepsy clinic / OPD, by telephonic interview. All the above information will be recorded in a data collection form consisting of relevant questionnaire. After completion, data analysis will be done by SPSS version 26 (Chicago, Illinois, USA).
Systems and methods of deep-learning neurocognitive impairment evaluation using extended reality. One system includes an electronic processor configured to generate an extended reality user environment (“XR-UX”) for display via a user device, the XR-UX including a first augmented object configured to change position within the XR-UX and a second augmented object configured to dynamically change position within the XR-UX based on a position of the user device. The electronic processor is also configured to control the first augmented object to traverse a path within the XR-UX. The electronic processor is also configured to receive motion data describing movement of the user device. The electronic processor is also configured to determine a medical classification based on the physical movement of the user device in relation to the path. The electronic processor is also configured to generate and transmit an assessment report for display, the assessment report including the medical classification.
Like other Semitic languages, Arabic is known for its rich morphology and consonantal writing system. In this article, we report the first case of acquired surface dyslexia in an Arabic-speaking patient (HBS). Surface dyslexia is characterised by difficulty reading irregularly spelled words, while performance is better with regular words and nonwords. The purpose of this study was to describe the symptoms of surface dyslexia in Arabic and to investigate how orthographic depth may affect reading in the context of semantic impairment. In HBS, who had Alzheimer's disease, reading was impaired for both words and nonwords. Her reading performance was affected by orthographic ambiguity and by the presence of diacritics depicting short vowels. In particular, she produced mainly vowel errors, suggesting an overreliance on the sublexical route of reading. On the other hand, HBS was able to distinguish long vowels from consonants represented by the same letters, provided there was a real root. This finding can be taken as evidence that HBS could access the word's root to decide whether the vowel letter represents a long vowel or a consonant. The results of this study suggest that the characteristics of surface dyslexia appear to be universal: reading regular words is spared compared to irregular words and non-words. However, the error patterns that HBS showed in reading support a language-specific conceptualisation of the processing components of the lexical and sublexical routes of reading.
INTRODUCTION: The aim of this study was to compare the results of cementless bilateral total knee arthroplasty (TKA) between individuals in different obesity groups.
MATERIALS AND METHODS: This was a retrospective cohort study. Patients with a body mass index (BMI) greater than 25 who underwent bilateral TKA for gonarthrosis between 2014 and 2020 and completed a minimum follow-up of 24 months were included. Age, sex, height, weight, BMI, operation time, length of stay, patient satisfaction, knee scores and complications were compared. Patients with missing data, who were followed for less than 24 months or had postoperative fractures around the knee were excluded.
RESULTS: There was a significant difference between the groups in terms of operation time (Class III > overweight > Class II > Class I p < 0.001). There was a significant difference in complications between the groups (Class III > Class I > Class II > overweight p = 0.010). According to our pairwise comparison, complications were more common in the class III group than in the overweight group. Knee score (KS) and function score (FS) increased significantly after surgery in all groups (p < 0.001), with no difference in FS (p = 0.448). Knee score changes were greater in the overweight and class I groups (p < 0.001). There was a significant interaction between both KS and FS and person satisfaction (p < 0.001).
CONCLUSION: Cementless TKA improved KS and FS in all obesity groups, yielded high patient satisfaction. Although the incidence of complications was higher in the morbidly obese patients than in the overweight patients, the difference was not significant. Patients with morbid obesity should be informed about related risks before planning cementless TKA.
The Australian Paediatric Surveillance Unit (APSU), established in 1993 to address the paucity of national data on rare childhood disorders, has become an invaluable research resource. It facilitates prospective, active surveillance for a variety of rare disorders, with monthly reporting by ~1500 paediatricians, who are invited to notify incident cases and provide demographic and clinical data. APSU is highly collaborative (used by >400 individuals/organisations), patient-informed and productive (>300 publications). In 30 years, 72 studies have been initiated on rare infections, and genetic, psychological and neurological disorders, and injuries. Return rates of monthly report cards were >90% for 30 years and paediatricians have provided data for >90% of notified cases. Although there are limitations, including case underascertainment in remote regions, APSU often provides the only available national data. APSU has assisted the government in reporting to the WHO, developing national strategies, informing inquiries and investigating disease outbreaks. APSU data have informed paediatrician education, practice, policy, and service development and delivery. APSU was integral in establishing the International Network of Paediatric Surveillance Units (INoPSU) and supporting development of other units. APSU's expanded remit includes one-off surveys, hospital audits, systematic reviews, studies on the impacts of rare disorders on families, surveillance evaluations, and joint studies with INoPSU members. Paediatricians value the APSU, reporting that APSU data inform their practice. They must be congratulated for an outstanding collective commitment to the APSU, in providing unique data that contribute to our understanding of rare disorders and support optimal, evidence-based care and improved child health outcomes.
PROBLEM TO BE SOLVED: To provide a lipid metabolism improving agent daily and tastily ingestible in the same manner as that of usual tea. SOLUTION: This lipid metabolism improving agent is obtained by including an ingredient extracted from an aged tea material prepared by mixing the tea material with liquors and an acid fermented milk and aging the resultant mixture with an aqueous solvent as an active ingredient. The resultant lipid metabolism improving agent has inhibitory actions on rise in hepatic lipids. The tea material is preferably one or more kinds selected from green teas, Chinese teas, black teas and barley teas. The liquors are preferably one or more kinds selected from Sake, wines, whiskeys, brandies, vodkas, Shaoxing and Shochu (Japanese distilled spirit). Furthermore, the acid fermented milk is preferably yogurts, acid milk beverages or lactic acid bacteria beverages.
Metered Dose Inhaler (MDI) and Dry Powdered Inhaler (DPI) are the two most common platforms to deliver medicine for patients suffering from Asthma and chronic obstructive pulmonary disease, and are used for dispensing both controller and rescue medications. Despite well-known methods to manage Asthma and COPD, nearly 70-90% of the patients do not display correct technique in using an inhaler. Poor management and control of the disease due to inadequate inhaler usage has resulted in rising rates of hospitalizations, making chronic respiratory diseases among the top five causes of death worldwide. Through this study we aim to record the technique of MDI usage among Asthma and COPD patient and understand the errors in their technique. The various parameters of inhaler usage where patients can make an error are 1. Tidal volume, 2. inspiration flow rate, 3. Inspiration flow volume, 4. Timing of actuation of inhaler and 5. Breath-holding. The parameters will be recorded by the Cognita R3 electronic flowmeter for each patient and the errors in each MDI usage will be noted. Using ex-vivo modelling, the patient's MDI technique recorded will be used to study the impact of errors in technique on efficiency of MDI drug delivery.
PURPOSE: A cosmetic composition containing Kimchi Lactobacillus fermentation liquid and S. Nigra bark extract is provided to ensure excellent antibacterial effect with body safety. CONSTITUTION: A cosmetic composition contains 0.001-30 wt% of Kimchi Lactobaillus fermentation liquid and S. Nigra bark extract. The Kimchi Lactobacillus is Leuconostoc sp., Lactobacillus sp., or Weissella sp. The S. Nigra bark extract is prepared by isolating pulverized S. Nigra bark with purified water, methanol, ethanol, propyl alcohol, butyl alcohol, glycerine, butylenes glycol, propylene glycol, methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, or mixture thereof. The composition additionally contains charmomile extract, Centella asiatica extract, or lemon balm extract. The composition is manufactured in the form of a lotion, essence, lotion, cream, gel, ointment, or cleanser.