anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In verapamil-sensitive left posterior fascicular ventricular tachycardia (LPF-VT), radiofrequency catheter ablation (RFA) is performed targeting mid-to-late diastolic potential (P1) and presystolic potential (P2) during tachycardia. This study included four patients who had undergone electrophysiological study (EPS) and pediatric patients with verapamil-sensitive LPF-VT who had undergone RFA using high-density three-dimensional (3D) mapping. The included patients were 11-14 years old. During EPS, right bundle branch block and superior configuration VT were induced in all patients. VT mapping was performed via the transseptal approach. P1 and P2 during VT were recorded in three of the four patients. All patients initially underwent RFA via the transseptal approach. In three patients, P1 during VT was targeted, and VT was terminated. The lesion size indices in which VT was terminated were 4.6, 4.6, and 4.7. For one patient whose P1 could not be recorded, linear ablation was performed perpendicularly in the area where P2 was recorded during VT. Among the three patients in whom VT was terminated, linear ablation was performed in two to eliminate the ventricular echo beats. In all patients, VT became uninducible in the acute phase and had not recurred 8-24 months after RFA. High-density 3D mapping with an HD Grid Mapping Catheter allows recording of P1 and P2 during VT and may improve the success rate of RFA in pediatric patients with verapamil-sensitive LPF-VT.
The invention relates to foot bathing liquid extracted from pure plant essences and a preparation method of the foot bathing liquid. The foot bathing liquid is characterized in that Chinese herbal medicine components with reasonable compatibility are carefully selected and strictly sifted and combined through experiments. The foot-bathing liquid has a good compound effect, is prepared by a special process, and is convenient to prepare and use. The foot-bathing liquid is extracted from the pure Chinese herbal medicine essences, and does not contain any chemical component. The foot bathing composition and the preparation method thereof aim to prevent and treat dermatomycosis easy to occur in summer. The foot-bathing composition has no toxic or side effect on a human body, has the efficacies of sterilizing, relieving itching, clearing heat, removing toxicity, removing dampness and moistening feet, is suitable for people suffering from foot cutaneous pruritus, women suffering from foot diseases caused by high-heeled shoes, and the crowd suffering from various chronic diseases of digestive and urogenital systems.
PURPOSE:To provide a new platinum complex having low toxicity compared with conventional platinum complex and useful as an antitumor agent giving high antitumor effect. CONSTITUTION:The platinum complex of formula, e.g. (1R,2R)-bis(glycolato) diaminocyclohexane platinum(II) dihydrate. The compound of formula can be produced e.g. by using a dinitratoplatinum complex containing 1,2- cyclohexanediamine as a supporting ligand [e.g. dinitrato(diaminocyclohexane) platinum(II)] as a raw material, contacting the material with an OH-type anion- exchange resin (preferably by using a column) to convert the nitrato group of the complex to OH, mixing the product with glycolic acid and distilling out the solvent using a rotary evaporator, etc., in hot water at about 70 deg.C. The complex of formula is used as a peroral medicine such as tablet or granule and administered at daily dose of 10-600g for adult in several divided doses.
To participate in this study, patients will need to have a central line (a thin plastic catheter or tube that is placed during surgery into one of the large veins in the neck or chest). Central lines are used to give intravenous medications or to draw blood. Before the transplant we will test the patients blood for viruses which can cause problems after the transplant. These viruses include Hepatitis B, which causes liver damage, cytomegalovirus, which causes lung disease and HIV which causes AIDS. If a patient is positive for the AIDS virus, they will not be able to undertake the transplant. In addition to these blood tests patients will also have an MRI (where pictures are created using magnetic rather than x-ray energy) of the brain and other evaluations that are standard for any patient before having a transplant.

Before the transplant patients will receive daily G-CSF (Neupogen). This medicine will help to stimulate the production of white blood cells (WBC) that will be used for the bone marrow transplant. In addition, 6 tablespoons of blood will be collected to look at how the immune system is functioning before and after transplant. After the white blood cells have reached a certain level, patients will undergo leukapheresis. Leukapheresis is a procedure where blood is removed from a patients arm, pumped into a machine where the white blood cells are separated from most of the other cells, then returned to the patient through the same needle or through a needle in the other arm. After collection of the white blood cells, we will use a device in the lab to select out certain types of white blood cells (CD34+).

After leukapheresis, patients will receive an antibody from horses called Atgam (ATG) to help destroy the immune system and also a drug called cyclophosphamide. After this, radiation treatment will be given to the entire body. This will be done 2 times a day for 3 days. This treatment will kill most of the blood-forming cells in the bone marrow. We will then give the CD34+ white blood cells that were collected during leukapheresis.

Blood will be collected for immune reconstitution studies monthly for 3 months and at 6, 9, and 12 months after transplant to look at how the immune system is functioning. The amount of blood taken will be no more than 90ml (6 tablespoons). After the first year of treatment patients will continue to have 90ml (6 tablespoons) of blood taken for immune reconstitution studies every 6 months for 2 more years.
All eligible patients being seen in the Gynecology Center at the M.D. Anderson Cancer Center and at Gynecologic Oncology of Houston for follow-up or a new diagnosis of ovarian cancer will be asked to participate in this study by completing a questionnaire.

This study will end when 400 completed questionnaires have been collected. We estimate that 40-60 ovarian cancer patients are seen in the Gynecology Center at the M.D. Anderson Cancer Center each week and that 20- 40 ovarian cancer patients are seen at Gynecologic Oncology of Houston each week. The completion of 400 questionnaires will provide adequate data to address our question in an expeditious time frame. The initial phase of this study is exploratory and does not involve a comparison group.
The subject will present for three baseline visits, followed by a treatment visit and subsequently follow-up visits at 24-hours, 48-hours, 1 week, 2 weeks, 1 month, and 3 months. Feasibility will be assessed as well as symptoms via detailed symptom rating scales at each visit. At the treatment visit itself, participants will undergo MR-guided low-intensity focused ultrasound of the MD thalamus.
AIMS: Inferior meatus augmentation by injection or implants is one of the treatments for empty-nose syndrome (ENS), but levels of evidence of efficacy are low. We present the technique and evaluate our experience. The primary objective was to analyze changes in Empty Nose Syndrome 6-item Questionnaire (ENS6Q) scores after treating patients with ENS by autologous fat injection. Secondary objectives were the analysis of the evolution of each of the six ENS6Q items and identification of complications. Eleven patients underwent a minimally invasive approach to limit nasal airflow using fat injection between March 2021 and December 2022.
RESULTS: Ten of the 11 patients showed a decrease in overall ENS6Q score (P=0.0058); 6 had a final ENS6Q score<11. Ten were satisfied with the procedure, but remained symptomatic. The procedure did not result in any complications.
CONCLUSION: These encouraging results confirm the data in the literature suggesting that fat injection improves symptomatology in empty nose syndrome. However, like other minimally invasive approaches to limit nasal airflow, it does not eliminate all symptoms. These results need to be confirmed by studies on larger cohorts with longer follow-up, preferably in a multicenter setting.
NEW MATERIAL:A compound shown by the formulaI(X is H, OH, or amino) or its acid addition salt. EXAMPLE:2-Deoxykanamycin A. USE:A drug useful for remedying infectious diseases of Gram-positive and Gram- negative bacteria. PROCESS:The amino-protecting group of a kanamycin derivative shown by the formula II is eliminated from it by alkali hydrolysis, acid hydrolysis or hydrogenolysis, to give a compound shown by the formulaI. In the case of the alkali hydrolysis, the derivative is heated in a saturated aqueous solution of BaOH, 5N NaOH or KOH solution. The compound shown by the formula II wherein X is H as a starting raw material is obtained by subjecting 4 amino groups of kanamycin A to N-protection, protecting them with OH, deprotecting selectively the 2'-O-protecting group of the prepared compound, subjecting the resulted compound to selective 2'-O-sulfonylation, reacting the prepared compound with sodium thiophenolate, followed by reduction and deacylation.
The placebo lighting intervention is designed to have no effect on the circadian system. The control intervention will be in place for 8 weeks. Following an 8 week washout period, the participants will see the active tailored lighting intervention for 8 weeks.
Our study was conducted as a cross-controlled study on 20 geriatric individuals. The study lasted 12 weeks. The participants in the study were given group otago exercises for 4 weeks, face to face once a week for 30 minutes, and remotely monitored twice a week with handouts containing the exercises. They were asked to walk normally for 30 minutes on 2 days a week. Then, they entered a 4-week washout period. After the washout period, the participants in the study were given group otago exercises for 4 weeks, face to face for 30 minutes, and remotely monitored twice a week with handouts containing the exercises. They were asked to walk normally for 30 minutes on 2 days a week. Before starting the study, participants were given a demographic information form, Tampa Kinesiophobia Scale for kinesiophobia, Berg Balance Scale for balance assessment, Short Form Geriatric Depression Scale for psychosocial status, 5-times sit-to-stand test to assess fall risk and lower extremity muscle strength, Timed Up and Go test to assess mobility, and Mini Mental State Test and Montreal Cognitive Assessment Test to assess cognitive function. These tests were repeated at the end of the first 4 sessions and the last 4 sessions, and pre- and post-test values were measured.
FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to ophthalmology. For surgical treatment of corneal dystrophy, anterior chamber moisture is sampled in amount of 0.1 ml, which is filled with 0.1 ml of sterile 0.1 % isotonic solution of riboflavin mononucleotide. Mechanical removal of corneal epithelium with diameter of about 7–8 mm is performed. Corneal stroma is saturated with riboflavin by means of installations of the photosensitizer Dextralink for 40 minutes. After this, UV irradiation of the cornea is performed in accelerated mode at wave length 370 mm, power 15 mW/cm, with radiation fluence of 7.2 J/cm, duration of 8 minutes. During irradiation simultaneous installation of photosensitizer Dextralink is performed every 3 minutes. Further, posterior automated layer-by-layer keratoplasty is performed by standard technique.EFFECT: method provides stable pain management, reduced recurrences in postoperative period due to higher efficiency of interfibrillar stitching and depth of cross-linking, reduced duration of procedure.1 cl, 1 ex
The rehabilitation group will be only treated with the Otago exercise program(OEP). The Otago Exercise is a program developed by the research group of fall prevention in the elderly led by Campbell of Otago Medical University in the 1990s. It is a home exercise program aimed at strengthening lower extremity muscle, balance and preventing falls in the elderly. Otago Exercise combines resistance exercise, balance training and aerobic walking and is an exercise prescription for elderly patients with sarcopenia (details are as follows).
Before the injection, patients will be asked to lie in the prone position. The acupressure point (UB32) will be located on the side to be injected. The UB32 point is located in the sacrum region, below the medial and posterior superior iliac spine, in the second sacral foramen. The acupressure point UB32 will be pressed circularly with a stopwatch for 1 minute. Then the acupressure point will be pressed three times in sequence with the thumb directly (pressure equal to 4.5 kg/cm2). Diclofenac sodium (75mg/3ml) will be injected after acupressure.
Band Together exercise intervention with behavior change techniques applied. 3 times weekly group exercise intervention held over Zoom featuring strength and balance exercises for 45 minutes with added reminders, education, goal setting, self monitoring, and feedback to encourage adherence and effort.
Endocervical adenocarcinomas (EACs) are a group of malignant neoplasms associated with diverse pathogenesis, morphology, and clinical behavior. As a component of the International Society of Gynecological Pathologists International Endocervical Adenocarcinoma Project, a large international retrospective cohort of EACs was generated in an effort to study potential clinicopathological features with prognostic significance that may guide treatment in these patients. In this study, we endeavored to develop a robust human papillomavirus (HPV)-associated EAC prognostic model for surgically treated International Federation of Gynecology and Obstetrics (FIGO) stage IA2 to IB3 adenocarcinomas incorporating patient age, lymphovascular space invasion (LVSI) status, FIGO stage, and pattern of invasion according to the Silva system (traditionally a 3-tier system). Recently, a 2-tier/binary Silva pattern of invasion system has been proposed whereby adenocarcinomas are classified into low-risk (pattern A/pattern B without LVSI) and high-risk (pattern B with LVSI/pattern C) categories. Our cohort comprised 792 patients with HPV-associated EAC. Multivariate analysis showed that a binary Silva pattern of invasion classification was associated with recurrence-free and disease-specific survival (P < 0.05) whereas FIGO 2018 stage I substages were not. Evaluation of the current 3-tiered system showed that disease-specific survival for those patients with pattern B tumors did not significantly differ from that for those patients with pattern C tumors, in contrast to that for those patients with pattern A tumors. These findings underscore the need for prospective studies to further investigate the prognostic significance of stage I HPV-associated EAC substaging and the inclusion of the binary Silva pattern of invasion classification (which includes LVSI status) as a component of treatment recommendations.
Low back pain (LBP) is a common problem among US adults. Initial episodes tend to be self-limited ("acute"), but some people can progress to a state of persistent pain. Often termed "chronic" LBP (cLBP), this condition can cause prolonged difficulty with most daily activities, including job performance. Most patients see chiropractors or primary care physicians (PCPs) for initial episodes of LBP. This study will compare two approaches for preventing patients with acute LBP (aLBP) from developing cLBP using a cluster randomized trial. Both treatments can be delivered in an outpatient PCP setting. The first approach is to provide PCPs with information regarding a patient's risk of transitioning from aLBP to cLBP and to encourage PCPs to treat patients according to accepted clinical guidelines (Guideline Based Care, GBC). The second approach is to provide the same risk information and have PCPs team up with physical therapists to deliver psychologically-informed physical therapy (PIPT) for those patients determined to be at high risk for transitioning to cLBP (GBC+PIPT). PIPT is designed to help patients identify and overcome physical and psychological barriers to recovery. The 1,860 patients expected to be enrolled as part of quality improvement at five regional sites (Pittsburgh, Pennsylvania; Boston, Massachusetts; Baltimore, Maryland; Charleston, South Carolina; and Salt Lake City, Utah) will start the study when their LBP is in an acute phase. The study's primary aims are to compare the proportions of cLBP and measures of functional ability between the two groups at 6 months. Secondary aims are to measure the referrals to physical therapists and specialists, opioid prescriptions, LBP-related x-rays or MRIs, surgeries, and other medical procedures during a 12-month follow-up period. This study was designed with input from a variety of national and local stakeholders, including patients with LBP, providers, payers, professional organizations, purchasers, and policy representatives.
PURPOSE:To readily produce odorless, tasty juice containing medicinal effect components in a short time by preparing green juice from fresh Houttuynia cordata, roughly filtering and oxidizing the juice. CONSTITUTION:Fresh Houttuynia cordata is ground into a slurried state and pressed. The prepared green juice is preferably mixed with an enzyme such as pectinase. The prepared green juice is roughly filtered by a well-known method. Then the juice is oxidized with an oxygen gas, an oxidizing agent or both. The oxygen gas, for example, is introduced as fine bubbles to the roughly filtered juice. An oxidizing agent usable for food is used as the oxidizing agent and is reacted while heating in a reactor. In order to treat in a short time, preferably both the oxygen gas and the oxidizing are used.
The present disclosure concerns embodiments of a combination and/or composition comprising bacillus, and yucca, quillaja or both. Embodiments of methods of making and using the combination and/or composition also are disclosed herein. In some embodiments, the combination and/or composition may be used to improve feed conversion rates in animals. In some embodiments the animals are avians; in other embodiments, the animals are non-avians. Embodiments of the disclosed combination can comprise a first composition comprising Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans. Embodiments of the disclosed composition can comprise Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans.
Participants in the treatment condition were emailed a link to the MoodHacker mobile-web app and instructed to use the program for the next six weeks. Participants were asked to complete 2 follow-up assessments, 6 weeks and 10 weeks after baseline.
A large amount of evidence shows that different kinds of microorganisms can jointly cope with environmental pressures including cell hosts. For example, in many cases, it has been found that secondary or mixed infection of animals caused by ORFV (an epitheliophilic Parapoxvirus) and bacteria (such as Staphylococcus aureus or Streptococcus) shows a mutual aid mode that indirectly leads to the deterioration of the disease. However, the lack of research on the co-pathogenic mechanism, including how to hijack and destroy the cell host in the pathological microenvironment, has hindered the in-depth understanding of the pathogenic process and consequences of this complex infection and the development of clinical treatment methods. Here, we summarized the current strategies of trapping cell hosts together, based on the previously defined ORFV-Host (O-H) system. The opportunistic invasion of S. aureus destroyed the delicate dynamic balance of the O-H, thus aggravating tissue damage through bacterial products (mediated by Agr), even causing sepsis or inducing cytokine storms. In fact, the virus products from its adaptive regulatory system (VARS) weaken the immune attacks and block molecular pathways, so that S. aureus can settle there more smoothly, and the toxins can penetrate into local tissues more quickly. This paper focuses on the main challenges faced by cell hosts in dealing with mixed infection, which provides a starting point for us to deal with this disease in the future.
BACKGROUND In the last 2 decades, the use of bioprosthetic valves for surgical aortic valve replacements has surged, now accounting for over 85% of all such surgeries. However, their limited durability has led to an increase in aortic valve reoperations and re-interventions. Here, we describe a unique case involving a patient with severe aortic regurgitation and cardiogenic shock, caused by a bioprosthetic aortic valve with a flail leaflet, which was replaced via a surgical approach. CASE REPORT A 58-year-old man with a history of atrial fibrillation, stent placement in the left anterior descending artery, and 2 aortic valve replacements presented to the Emergency Department with severe chest pain and shortness of breath. A chest X-ray showed significant pulmonary vascular and interstitial congestion, and cardiac catheterization displayed nonobstructive coronary artery disease. A transesophageal echocardiogram (TEE) revealed severe regurgitation in the prosthetic aortic valve, resulting in the patient being sent for emergency aortic valve replacement. An intraoperative TEE showed evidence of prosthetic valve failure with complete prolapse of the noncoronary cusp. The prosthetic aortic valve's noncoronary cusp leaflet was found flailing into the left ventricular outflow tract, while the other 2 leaflets seemed normal. The valve was replaced and a new Medtronic Avalus size 27 mm valve was seated. Postoperatively, the patient developed a complete heart block requiring placement of a permanent dual-chamber pacemaker. CONCLUSIONS Flailed leaflets in bioprosthetic aortic valves are a rare complication of aortic valve replacement. Redo surgical valve replacement is a viable treatment for bioprosthetic failure due to leaflet flail.