anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
On-clamp partial nephrectomy for the surgical treatment of renal masses poses the risk of ischemia and greater post-operative renal function loss. Conversely, the off-clamp technique might enhance renal function preservation by avoiding any ischemia time. Nevertheless, the debate persists regarding the efficacy of the on- versus off-clamp partial nephrectomy in achieving better surgical, functional, and oncological outcomes. We retrospectively assessed the data from patients undergoing Robot-Assisted Partial Nephrectomy (RAPN) from 2016 and 2023 in a tertiary robotic center. Inverse probability of treatment weighting (IPTW) was used to account for selection bias in treatment allocation. The main objective of the study was assessing the achievement rates of a modified trifecta within the two groups. Multivariable logistic regression analysis (MLRA) was employed to assess the predictors of trifecta achievement. 532 patients were included in the analysis, of whom 74.1% vs. 25.9% underwent on- and off-clamp, respectively. Balancing the two groups for the main predictors of on-clamp surgery, there were no significant differences between on- and off-clamp in terms of estimated blood loss, transfusion rate, intra- and post-operative complications, positive surgical margins, and post-operative mean reduction of eGFR. Finally, no differences were found in the rate of "trifecta" achievement between on-clamp and off-clamp RAPN (24.6% vs. 21%, p = 0.82). At MLRA, off-clamp technique was not a predictor of trifecta achievement compared to the on-clamp technique (off-clamp vs. on-clamp, aOR 1.24, 95% CIs [0.65-2.36], p = 0.58). Our study revealed that clamping technique does not imply clinically relevant differences in reaching trifecta outcomes.
This study investigates how American Sign Language (ASL) fluency and hearing status influence the perception of biological motion, using three point-light display (PLD) tasks. Prior research indicates that early exposure to ASL among deaf signers results in more rapid and effortless recognition of biological motion than hearing nonsigners, potentially due to the expertise in deciphering complex human movements or possibly due to neuroplasticity in deaf brains. However, it remains uncertain whether this advantage stems from signed language proficiency or the experience of being deaf. To explore this, we designed three PLD tasks involving viewing randomly moving dots, identifying a person from biological motion PLDs, and determining whether right-side up and inverted PLDs depict actions involving a ball. A diverse cohort of participants (N = 224) with varying ASL fluencies and hearing statuses completed the tasks online, providing us with reaction time and accuracy data. Our results demonstrate that earlier ASL exposure is associated with accuracy, especially on complex action identification tasks. Furthermore, we discovered robust evidence for a speed-accuracy trade-off in deaf participants, in which they performed more quickly but less accurately. The speed-accuracy trade-off was evident in the most difficult task, the action identification task. Further analysis of this deaf group revealed that earlier signed language acquisition led to higher accuracy in action identification task. We conclude that age of ASL exposure and hearing status both significantly contribute to variations in biological motion perception, with implications for understanding visual expertise and cognitive processing in both deaf and signing populations. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion (I/R) injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodeling without influencing infarct size. In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. This augmented adverse remodeling after I/R and led to an increased infarct size and deterioration of cardiac function. In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodeling, while recruited macrophages determine infarct size after I/R injury. These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction.
INTRODUCTION: Coronavirus disease 2019 (COVID-19) has caused many injuries and deaths worldwide. Obesity is reported to be an important risk factor for severe COVID-19, although the underlying mechanism is not fully understood. The present study aimed to determine whether obesity or being overweight is associated with the clinical course and severity of COVID-19 in children.
METHODOLOGY: In this retrospective study, pediatric patients under the age of 18 years, who applied to our hospital between June 2021 and August 2021, and tested positive with the COVID-19 reverse transcriptase-polymerase chain reaction test were included. Age, gender, symptoms at admission, body weight, height, chest radiographs, hemograms, C-reactive protein and other laboratory findings, and days of hospitalization of the pediatric patients were obtained from the hospital automation system. All data were statistically analyzed and compared between underweight, normal, overweight, and obese groups; categorized according to body mass index (BMI).
RESULTS: The study included 116 patients. The results showed that the incidence of symptoms was higher in overweight and obese children compared to other groups (p < 0.05), while the rate of lung involvement was significantly higher in obese patients compared to other groups (p < 0.05). The optimum cut-off point for BMI percentile values in terms of lung involvement was determined to be > 91.
CONCLUSIONS: The results of this study revealed that obese children show more symptoms of COVID-19 disease than normal-weight children. In addition, these children have more frequent lung involvement and therefore have more severe disease.
The invention relates to medicine, in particular, to immune donorship and provides to produce high-quality raw material (huperimmune plasm) from the blood of immunized donors for producing immuno-biologic medical preparations such as antistaphyloccol human immunoglobulin and antistaphyloccol human plasma. The clamed invention is aimed at producing blood plasma with increased titers of anti-α-staphylolysin from immune donors, shortening of immunonization, reducing antigen load on donor's organism. The invention is characterized in that the donor is double-immunized. The first immunization is carried out by injecting 1 subdermally 1 mg. of an adsorbed staphylococcal annitoxin in the region of the lower angle of the left blade-bone and additionally by Roncoleukin and injected subdermally 1000 IU/kg in the region of the lower angle of the right blade-bone after 30 minutes of injection of the adsorbed staphylococcal annitoxin. The second immunization is carried out 7 days later by injecting into the organism donor 1 mg. the adsorbed staphylococcal annitoxin. After each two weeks when immunization is started blood samples are taken with subsequent the plasma isolated therefrom.
AIMS: The "Warburg effect" has been developed from the discovery that hypoxia-inducible factor 1α (HIF-1α) could promote the conversion of pyruvate to lactate. However, no studies have linked hypoxia and lactate metabolism to uterine corpus endometrial carcinoma (UCEC).
MAIN METHODS: Sequencing and clinical data of patients with UCEC were extracted from The Cancer Genome Atlas (TCGA) database. Hypoxia-related lactate metabolism genes (HRLGs) were screened using Spearman's correlation analysis. A prognostic signature based on HRLGs was developed using the least absolute shrinkage and selection operator (LASSO) algorithm. A comprehensive analysis was conducted on the molecular features, immune environment, mutation patterns, and response to drugs between different risk groups. In vitro and in vivo experiments were performed to verify the function of KIF23.
KEY FINDINGS: A five HRLG-based prognostic signature was identified. The prognostic outcome was unfavorable for the high-risk subgroup. Observation of increased pathway activities associated with cell proliferation and DNA damage repair was noted in the high-risk subgroup. Additionally, notable correlations were observed between risk score and immune microenvironment, mutational features, and drug responsiveness. Further, we confirmed KIF23 as a novel oncogene in UCEC, whose silencing decreased proliferation and promoted apoptosis of cancer cells. KIF23 knockdown reduced tumor growth in nude mice. We demonstrated that KIF23 was upregulated under hypoxic stress in a HIF-1α dependent manner. Moreover, KIF23 regulated lactate dehydrogenase A expression.
SIGNIFICANCE: The developed HRLG-related signature was associated with prognosis, immune microenvironment, and drug sensitivity in UCEC. We also revealed KIF23 as a hypoxia-regulated lactate metabolism-related oncogene.
Screening tests will be conducted to determine whether or not subjects can participate in this study. If subjects are eligible and choose to participate, they will have a procedure called leukapheresis. The leukapheresis product that is collected from you will be taken to a special lab at MUSC where it will undergo a process that will grow additional dendritic cells under controlled conditions in the lab. These cells will be given together with Poly-ICLC therapy when you begin study treatment. Some days you will receive both Poly-ICLC and dendritic cells, but on other days you will receive the Poly-ICLC by itself. After study treatment, subjects may be asked to return to MUSC approximately every 3 months for the first 2 years, then every 6 months thereafter for follow up procedures.
PURPOSE:To provide the titled agent for absorbing long-wavelength ultraviolet radiation, containing a polyvalent metal salt of a specific dibenzoylmethane derivative, having improved safety to human body and durability of the absorbing effect and able to be made insoluble in water and organic solvents without lowering the activity to absorb long-wavelength ultraviolet radiation. CONSTITUTION:A UV-A absorbing agent containing a compound of formula [M is Al, Zn, Ca, Mg, Ba, Sr or Zr; m is atomic valence of M; n Y groups and l Z groups are same or different OH, 1-24C straight or branched-chain aliphatic hydrocarbon group, 1-24C alkoxy or polyoxy(2-3C)alkylene oxide land n are integer of 0-3]. The agent effectively shields harmful UV-A radiation to protect the skin and is stable to light and heat over a long period. Since the agent is insoluble in water, organic solvents, oily substances, sebum, etc., it is hardly absorbed through the skin. The effect lasts long because of the resistance of the agent to water and sweat. Accordingly, the agent is useful in the fields of cosmetics and pharmaceuticals, especially cosmetic field as an ultraviolet absorber and a cosmetic base.
The method for obtaining the polyphenol complex possessing anti-inflammatory, cardioprotective, and antioxidant activities comprises the extraction of the herbal material with 50% ethanol followed by evaporation. Then the extract is treated with ethanol followed by evaporation and drying. The herb of the bitter peavine is used as the raw material. For extraction, ethanol is added to the herb at a 7:1 ratio for 48 hours. The extract then is evaporated to 1/7-1/8 of the initial volume followed by then treatment with 96% ethanol at a 1:1.5 extract : ethanol ratio. The pellet is discarded while the supernatant is evaporated to 1/3 of the initial volume and dried.
Patients receive eribulin IV over 2-5 minutes and gemcitabine IV on days 1 and 8. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI and bone scan throughout the trial. Patients also undergo blood and urine sample collection on the trial.
Chronic kidney disease (CKD) is a burden in low- and middle-income countries, and a late diagnosis with systemic arterial hypertension (SAH) is the major complication of CKD. C-phycoerythrin (CPE) is a bioactive compound derived from Phormidium persicinum that presents anti-inflammatory and antioxidant effects in vitro and nephroprotective effects in vivo. In the current study, we determine the antihypertensive effect of CPE in a 5/6 nephrectomy-induced CKD model using twenty normotensives male Wistar rats, grouped into four groups (n = 5): sham; sham + CPE; 5/6 nephrectomy (NFx); and NFx + CPE. Treatment started a week post-surgery and continued for five weeks, with weekly hemodynamic evaluations. Following treatment, renal function, oxidative stress, and the expression of vascular dysfunction markers were assessed. The renal function analysis revealed CKD hyperfiltration, and the hemodynamic evaluation showed that SAH developed at the third week. AT1R upregulation and AT2R downregulation together with Mas1/p-Akt/p-eNOS axis were also observed. CPE treatment mitigated renal damage, preserved renal function, and prevented SAH with the modulation of the vasodilative AT1R, AT2R, and Mas1/pAKT/peNOS axis. This result reveals that CPE prevented CKD progression to SAH by avoiding oxidative stress and vascular dysfunction in the kidneys.
Obesity is a complex disease associated with augmented risk of metabolic disorder development and cellular dysfunction in various species. The goal of the present study was to investigate the impacts of obesity on the metabolic health of old mares as well as test the ability of diet supplementation with either a complex blend of nutrients designed to improve equine metabolism and gastrointestinal health or L-carnitine alone to mitigate negative effects of obesity. Mares (n = 19, 17.9 ± 3.7 years) were placed into one of three group: normal-weight (NW, n = 6), obese (OB, n = 7) or obese fed a complex diet supplement for 12 weeks (OBD, n = 6). After 12 weeks and completion of sample collections, OB mares received L-carnitine alone for an additional 6 weeks. Obesity in mares was significantly associated with insulin dysregulation, reduced muscle mitochondrial function, and decreased skeletal muscle oxidative capacity with greater ROS production when compared to NW. Obese mares fed the complex diet supplement had better insulin sensivity, greater cell lipid metabolism, and higher muscle oxidative capacity with reduced ROS production than OB. L-carnitine supplementation alone did not significantly alter insulin signaling, but improved lipid metabolism and muscle oxidative capacity with reduced ROS. In conclusion, obesity is associated with insulin dysregulation and altered skeletal muscle metabolism in older mares. However, dietary interventions are an effective strategy to improve metabolic status and skeletal muscle mitochondrial function in older mares.
A clinical questionnaire system and method that includes a Web Browser (12), Web server (14) and database (16) that presents medical questions to a subject and determines additional questions to present based on the subject's response to previous questions. Positive responses to primary questions trigger presentation of secondary and lower-level questions requesting more specific information from the subject. Deeper-level questions follow a medical pathway correlated with a known medical condition and can prompt presentation of clinical warnings. Because the questionnaire is patient-centered, it is free from the medical bias inherent in a physician's administration of a questionnaire and orientation as to what constitutes true disease. By only presenting relevant questions, the questionnaire decreases the time burden on the subject. Longitudinal clinical data collected can be used for patient-oriented data analysis or, in combination with bioanalytical data, for biological marker discovery.
The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer, targets delivery of the drug moiety to tumors, and intracellular accumulation therein, whereas systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells. The present invention provides pyrrolobenzodiazepine (PBD) dimer conjugates comprising cathepesin labile and PEGylated linkers, which may further comprise a maleimide functional group, bound to a CD19 antibody to create ADCs. In particular, in the conjugates of the present invention the antibody is an antibody that binds to CD19, the antibody comprising a VH domain paired with a VL domain, the paired VH and VL domains having the sequences of: SEQ ID NO. 1 paired with SEQ ID NO. 7, or SEQ ID NO. 2 paired with SEQ ID NO. 8 wherein the drug loading (p) of drugs (D) to antibody (Ab) is an integer from 1 to 8.
The apolipoprotein E epsilon 4 (APOE e4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by the World Health Organization highlighted the potential protective role of physical activity and exercise against cognitive decline, all-cause dementia, AD, and vascular dementia in healthy individuals. In an 18-month longitudinal observational study, investigators showed that sedentary e4 carriers experience significant declines in episodic memory and hippocampal volume compared to 4 carriers who engaged in moderate PA. Importantly, among 4 non-carriers, no significant longitudinal changes in cognition and brain imaging were observed whether the non-carriers were sedentary or engaged in moderate PA, suggesting that PA has a specific neuroprotective role in delaying the progression of AD in e4 carriers. Based on the results, a pragmatic, randomized controlled trial with blinded clinical and imaging outcomes is proposed to determine the impact of a home based, high intensity exercise intervention in healthy, cognitively intact e4 carriers between the ages of 65 and 80 years. The CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) trial will recruit otherwise healthy sedentary carriers randomized to one of two groups (n=75 each): 1) an Indoor Cycling (IC) group that participates in high-intensity interval training (HIIT; 60-90% of heart rate reserve) in their home via the commercially available Peloton® cycling system or 2) a Usual and Customary Care (UCC) group, in which participants engage in their habitual level of PA. Investigators hypothesize that an 18-month high-intensity aerobic exercise regimen will slow AD-related disease progression in sedentary elders at genetic risk for AD. Participants in the intervention group will engage in exercise 3x/week (minimum 90 minutes/week) for 18 months. Primary outcome measures, obtained at study entry and at 18 months, will include comprehensive cognitive testing and brain MR imaging to assess disease progression and a comprehensive PA/fitness assessment to measure the degree of change in physical fitness due to high intensity aerobic exercise.
OBJECTIVES: Diagnosis of rumination syndrome (RS) relies on Rome IV criteria. Oesophageal high-resolution impedance manometry (HRIM) can objectively demonstrate the episodes of rumination, but its role in the diagnostic pathway is not yet established. We aimed to demonstrate the clinical contribution of this tool for the timely diagnosis of RS and diagnostic work-up of children with unexplained foregut symptoms deemed to be due to other conditions.
METHODS: HRIMs performed between 2012 and 2021 were searched to retrieve all diagnoses of RS. Medical records were reviewed for clinical data.
RESULTS: Out of 461 HRIMs performed, 76 children had manometric diagnosis of RS (35 male, median age: 13 years). Of them, 47% were not clinically suspected as the symptoms did not fulfil clinical criteria for RS. The indications for HRIM in these cases were investigation of unexplained foregut symptoms (37%), suspected refractory gastroesophageal reflux disease (8%) and dysphagia (2%). Among all HRIMs performed for investigations of unexplained foregut symptoms (n = 80), 35% demonstrated rumination episodes.
CONCLUSION: Identification of characteristic patterns of rumination on HRIM in children with unexplained foregut symptoms enables the immediate diagnosis of RS. Thus, in situations of diagnostic uncertainty, the use of HRIM at early stages of the diagnostic pathway would reduce unnecessary investigations and treatments.
INTRODUCTION: Critical illness polyneuropathy and myopathy (CIP/CIM) are frequent complications in the intensive care unit (ICU) with major consequences for the progress and outcome of subjects. CIP/CIM delays the weaning process, prolongs the hospital stay and increases the mortality rate. Additionally, it may have long-term consequences beyond the hospitalisation phase with prolonged disability. Even though there is growing interest in CIP/CIM, research about the clinical and post-clinical course as well as the middle-term and long-term outcomes of subjects with CIP/CIM is scarce. A large prospective study of critically ill subjects is needed with accurate diagnosis during the acute stage and comprehensive assessment during long-term follow-up.
METHODS AND ANALYSIS: This prospective observational cohort study aims to compare the clinical and post-clinical course of chronically critically ill subjects with and without the diagnosis of CIP/CIM and to determine predictors for the middle-term and long-term outcomes of subjects with CIP/CIM. In addition, the influence of the preclinical health status and the preclinical frailty on the long-term outcome of subjects with CIP/CIM will be investigated.This single-centre study will include 250 critically ill patients who were invasively ventilated for at least 5 days at the ICU and show reduced motor strength. At five study visits at admission and discharge to neurological rehabilitation, and 12, 18 and 24 months after disease onset, a comprehensive test battery will be applied including assessments of functioning and impairment, independence, health-related quality of life, activity and participation, cognition, gait and balance, fatigue, mental health and frailty.Secondary objectives are the documentation of therapy goals, therapy content and achieved milestones during the rehabilitation, to evaluate the clinimetric properties of the Mini-BESTest in critically ill patients, and to evaluate the time course and outcome of subjects with CIP/CIM after SARS-CoV-2 infection.
ETHICS AND DISSEMINATION: The study was approved by the ethical committee of the Ludwig-Maximilians University Munich. Participants will be included in the study after having signed informed consent.Results will be published in scientific, peer-reviewed journals and at national and international conferences.
TRIAL REGISTRATION NUMBER: German Clinical Trial Register (DRKS00021753).