anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with significant misuse, have been reported in hospitalized patients. Patients suffering from sickle cell disease (SCD) could represent a high-risk population for substance use disorder (SUD) due to their significant pain crisis and repeated use of EMONO. The objective of the PHEDRE study was to assess the prevalence of SUD for EMONO in French SCD patients.
RESULTS: A total of 993 patients were included. Among 339 EMONO consumers, only 38 (11%) had a SUD, with very few criteria, corresponding mainly to a mild SUD due to a use higher than expected (in quantity or duration) and relational tensions with the care teams. Almost all patients (99.7%) were looking for an analgesic effect, but 68% of patients were also looking for other effects. The independent risks factors associated with at least one SUD criterion were: the feeling of effects different from the expected therapeutic effects of EMONO, at least one hospitalization for vaso occlusive crisis in the past 12 months and the presence of a SUD for at least one other analgesic drug.
CONCLUSIONS: The use of EMONO was not problematic for the majority of patients. Manifestations of SUD that led to tensions with healthcare teams should alert and lead to an evaluation, to distinguish a true addiction from a pseudoaddiction which may be linked to an insufficient analgesic treatment related to an underestimation of pain in SCD patients.
TRIAL REGISTRATION: Clinical Trials, NCT02580565. Registered 16 October 2015, https://clinicaltrials.gov/.
SLT employs frequency doubled Q switched Nd:YAG laser with a wavelength of 532 nm. It is delivered in short nano second pulses and the resulting selective effect to the pigmented cells of the TM, leaving the surrounding non-pigmented cells unaffected. This increases the permeability of the TM endothelial cells and can assist in increasing outflow and hence result in reductions in IOP. The procedure lasts approximately 10 minutes, with delivering 100 separate laser beams through a manually rotated mirrored lens (gonioscope), involving prolonged contact with the participant's eye. This treatment is applied on the cornea through a gonioscopic lens which is used to direct the laser beam to the desired location - the TM (360 degrees of treatment area).
BACKGROUND: Consultations for sexually transmitted infection (STI) provide an opportunity to offer HIV testing to both patients and their partners. This study describes the organisation of HIV self-testing (HIVST) distribution during STI consultations in Abidjan (Côte d'Ivoire) and analyse the perceived barriers and facilitators associated with the use and redistribution of HIVST kits by STI patients.
MATERIALS AND METHODS: A qualitative study was conducted between March and August 2021 to investigate three services providing HIVST: an antenatal care clinic (ANC), a general health centre that also provided STI consultations, and a dedicated STI clinic. Data were collected through observations of medical consultations with STI patients (N = 98) and interviews with both health professionals involved in HIVST distribution (N = 18) and STI patients who received HIVST kits for their partners (N = 20).
RESULTS: In the ANC clinic, HIV testing was routinely offered during the first prenatal visit. HIVST was commonly offered to women who had been diagnosed with an STI for their partner's use (27/29 observations). In the general health centre, two parallel pathways coexisted: before the consultation, a risk assessment tool was used to offer HIV testing to eligible patients and, after the consultation, patients who had been diagnosed with an STI were referred to a care assistant for HIVST. Due to this HIV testing patient flow, few offers of HIV testing and HIVST were made in this setting (3/16). At the dedicated STI clinic, an HIVST video was played in the waiting room. According to the health professionals interviewed, this video helped reduce the time required to offer HIVST after the consultation. Task-shifting was implemented there: patients were referred to a nurse for HIV testing, and HIVST was commonly offered to STI patients for their partners' use (28/53). When an HIVST was offered, it was generally accepted (54/58). Both health professionals and patients perceived HIVST positively despite experiencing a few difficulties with respect to offering HIVST to partners and structural barriers associated with the organisation of services.
CONCLUSION: The organisation of patient flow and task-shifting influenced HIV testing and offers of HIVST kits. Proposing HIVST is more systematic when HIV testing is routinely offered to all patients. Successful integration requires improving the organisation of services, including task-shifting.
The invention relates to the field of treatment by Chinese herbs, in particular to a foot bath formula and method for treating a cold. The foot bath formula comprises, by weight, 25-35 g of rhizoma seu radix notopterygii, 30-40 g of radix angelicae pubescentis, 26-36 g of radix angelicae, 30-35 g of rhizoma chuanxiong and 28-34 g of herba ephedrae. The medicinal materials are cleaned and put in a pot for decocting herbal medicine together, a proper amount of clear water is added, soaking is conducted for 5-10 min, and then decoction is conducted with water to obtain juice; the juice is then placed in a bathtub, and foot bathing is conducted after temperature becomes proper, 10-30 min each time, twice a day; one dose each day, 3-5 days in a row. The foot bath formula and method can treat common cold due to wind-cold by relieving superficies syndrome with pungent and warm natured drugs and dispelling wind-cold. Under the action of hot water, the reflection regions of feet are stimulated, blood circulation of the human body is promoted, the endocrine system is regulated, human organ functions are enhanced, and therefore a healthcare effect of preventing and treating diseases is realized. Meanwhile, under hot water stimulation, microcirculation of feet is accelerated, pores are open, so that medicine can act on key acupoints and visceral organ projection areas on feet to regulate viscera functions, dispel coldness and warm the body, and finally the cold is treated.
OBJECTIVE: Postoperative nonfunctioning pituitary tumor (NFPT) regrowth is a significant concern, but its predictive factors are not well established. This study aimed to elucidate the pathological characteristics of NFPTs indicated for reoperation for tumor regrowth.
METHODS: Pathological, radiological, and clinical data were collected from patients who underwent repeat operation for NFPT at Moriyama Memorial Hospital (MMH) between April 2018 and September 2023. For comparison, we also gathered data from patients who underwent initial surgery for NFPT during the same period at MMH.
RESULTS: Overall, 61 and 244 NFPT patients who respectively underwent reoperation and initial operation were evaluated. The mean period between the previous operation and reoperation was 113 months. Immunonegativity for any adenohypophyseal hormone was significantly more frequent in the reoperation group than in the initial operation group. In addition, the rate of hormone-negative but transcription factor-positive (H-/TF+) tumors among silent gonadotroph tumors was significantly higher in the reoperation group than in the initial operation group. Furthermore, seven silent corticotroph tumors (SCTs) in the reoperation group were ACTH-negative but TPIT-positive. Because most of the previous surgeries were performed in other hospitals a long time ago, we could procure the previous pathological results with immunohistochemistry (IHC) only from 21 patients. IHC for TF had not been performed in all the previous specimens. IHC for adenohypophyseal hormone was almost the same as the current results, and many H-/TF+ tumors were previously diagnosed as NCT. In addition, the reoperated patients were classified into 3 groups on the basis of the condition of the previous operation: gross total resection (GTR), 12 patients; subtotal resection (STR), 17 patients; and partial resection (PR), 32 patients. The mean Ki-67 LI in the GTR, STR, and PR subgroups were 1.82, 1.37, and 0.84, respectively, with the value being significantly higher in the GTR subgroup than in the PR subgroup (P < 0.05).
CONCLUSIONS: The ratio of H-/TF+ tumors is significantly higher in symptomatically regrown tumors than in the initial cases, which used to be diagnosed as NCT. PR cases tend to grow symptomatically in a shorter period, even with lower Ki-67 LI than GTR cases.
At the start of the study, subjects will be provided with a tablet with videoconferencing software and the PCT app pre-installed. Subjects in the control group will be told they will have access to 3-months of PCT after their participation in the study has concluded. Subjects in this group will be provided with a standard regime of paper workbooks and instructions to complete approximately 30 minutes a day at least 5 days a week.
The placebo group will receive placebo concentrate orally (0.3 mL/kg) only once, 1 to 2 hours before the oncologic procedure. All patients will undergo the same anesthetic protocol. Afterward, the patients will be submitted to oncologic procedures: Myelogram or Lumbar Puncture.
Breakfast consumption is generally considered a health-promoting habit for cardiometabolism, particularly with regard to chrononutrition. Glucose uptake is enhanced by proper insulin secretion triggered by the pancreatic clock, averting metabolic dysregulation related to insulin resistance. Breakfast skipping, in turn, is often considered a behaviour detrimental to health, in part due to putative inverse metabolic actions compared to breakfast consumption, such that breakfast skipping may promote circadian desynchrony. However, most ill health concerns about breakfast skipping are inferred from observational research, and recent well-controlled randomized clinical trials have shown benefits of breakfast skipping for cardiovascular risk factors. Accordingly, this review describes the effects of breakfast consumption versus breakfast skipping on cardiovascular risk factors (blood pressure and glycaemic and lipid indices). In addition, the view of breakfast consumption as an opportunity for functional food ingestion is considered to provide further insights into decision-making practice. Collectively, both breakfast consumption and breakfast skipping can be considered viable habits, but they depend on individual preferences, planning, and the specific foods being consumed or omitted. When consumed, breakfast should consist primarily of functional foods typical for this meal (e.g., eggs, dairy products, nuts, fruits, whole grains, coffee, tea, etc.). While breakfast consumption aligns with chrononutrition principles, breakfast skipping can contribute to a calorie deficit over time, which has the potential for widespread cardiometabolic benefits for patients with overweight/obesity. The concepts and practical considerations discussed in the present review may aid health care personnel in personalising breakfast consumption recommendations for diverse patient populations.
Simulation is defined as one of the methods that enables students to increase their knowledge and performance in an unreal, safe and risk-free environment and gain experience. Recent research involving the use of simulation in nursing education has mostly focused on the development of cognitive learning and psychomotor skills. However; A limited number of simulation studies have been found that include empirical evaluation of affective learning domains such as affective awareness, self-awareness and empathy. As well as the cognitive and psychomotor domains of nurse educators; It is very important for them to develop strategies to strengthen the affective field. It is predicted that the proportion of the elderly population in our country will increase in the coming years. With the increase in the elderly population, it is likely that there will be changes in the patient profile that nurses who are responsible for 24/7 individual care will encounter. Professional development is required to meet the needs of elderly patients. It is of great importance for nursing students who are still in the education stage to raise this awareness, to increase their self-awareness, to empathize with elderly individuals and to gain these characteristics. In this context, it is aimed to present results on the effects of the simulation scenario designed on the care of elderly individuals and the application of "Geriatric Medication Game" on the self-awareness levels and empathy skills of nursing students. Geriatric Medication Game is an aging simulation game that combines the experiences and challenges of older adults in healthcare and a structured role-playing where students assume the identity of healthcare-seeking seniors. It is designed to influence student attitudes and understanding of older adults and the healthcare system.
A method for treating and improving diabetes and liver dysfunction, can be obtained by administering at least one selected from a chitin oligosaccharide, a chitosan oligosaccharide and salts thereof, in an effective amount. As the chitin oligosaccharide, preferred is one having the degree of polymerization of from 2 to 7. As the chitosan oligosaccharide, preferred is one having the degree of polymerization of from 2 to 8. As the method for administration, it is preferred to add them to e.g. foods, medicines or feeds, and orally ingest them. However, when used as medicines, administration methods such as intravenous injection and muscular injection, may be used.
Caregivers are randomly assigned to one of two groups. The KEEP-P+ group completes an augmented version of the intervention with curriculum that includes the addition of information about recent findings in early brain development and a video coaching component based on the Filming Interactions to Nurture Development (FIND) program. The intervention content is delivered by a KEEP-P group facilitator in a 2-hour weekly group format. Duration of the program is 12 weeks.
The present disclosure provides a disinfectant liquid for disinfecting an animal. The present disclosure provides a disinfectant liquid that contains chlorous acid water, and that is used for disinfection of an animal by bringing the disinfectant liquid into contact with the animal. The contact is achieved by a rubbing method, a scrubbing method, or a basin method. The animal is a living animal. The animal includes an animal surface. The animal surface is skin. The animal surface is a finger. The animal includes a human body. The disinfection is performed in the preparation of food. The disinfectant liquid contains no animal-derived components, alcoholic components, or fragrances.
A method for selecting the prophylaxis of the dyshormonal diseases of the breast after the spontaneous abortion in the first trimester of the gestation comprises the anamnesis, the examination and the selection of the hormonal contraception within the first three days after the spontaneous abortion. Furthermore, the breasts are examined within the first three days after the spontaneous abortion. In case of hyperprolactinemia in anamnesis prior to the gestation or the tenderness in the breast with hardening of the nipples and the discharge of the milk or the colostrums are detected after the spontaneous abortion, dophaminergic drug of the sustained release is prescribed at a dose of half tablet daily for four days and then one tablet twice a week for at lest six months under the control of prolactin level. In case of the absence of hyperprolactinemia in anamnesis prior to gestation, two months later prolactin level in blood serum is re-assayed and the clinical examination of the breasts is performed. If at this moment hyperprolactinemia is absent while the tenderness in the breast with hardening of the nipples and the discharge of the milk or the colostrums are detected, the dophaminergic drug of the sustained release is prescribed at a dose of half tablet twice a week for three conventional cycles, 28 days each. In case of hyperprolactinemia is first recognized in two months after the spontaneous abortion, dophaminergic drug of the sustained release is prescribed at a dose of one tablet twice a week for at least six months independently of presence or absence of the tenderness in the breast with hardening of the nipples and the discharge of the milk or the colostrums. When the tenderness in the breast with hardening of the nipples and the discharge of the milk or the colostrums are not detected, the phytotherapeutic composition possessing the weak dophaminergic activity is prescribed, 30 drops twice a day for three months with the accompanying daily application of 2.5 g of 1% transdermal gel with micronized progesterone to the breasts.
BACKGROUND: Afferent innervation of shoulder joints plays a fundamental role in nociception and mechanoception and its alteration result in shoulder´s disease that course with pain and functional disability.
METHODS: Joints shoulder from healthy subjects (n = 20) and with chronic pain shoulder syndromes (n = 17) were analyzed using immunohistochemistry for S100 protein to identify nerve structures (nerve fibers and sensory corpuscles), coupled with a quantification of the sensory formations. Sensory nerve formations were quantified in 13 distinct areas in healthy joint shoulder and in the available equivalent areas in the pathological joints. Statistical analyses were conducted to assess differences between healthy shoulder and pathological shoulder joint (p< 0.05).
RESULTS: All analyzed structures, i.e., glenohumeral capsule, acromioclavicular capsule, the extraarticular structures (subcoracoid region and subacromio-subdeltoid bursa) and intraarticular structures (biceps brachii tendon and labrum articulare) are variably innervated except the extrinsic coracoacromial ligament, which was aneural. The afferent innervation of healthy human shoulder joints consists of free nerve endings, simple lamellar corpuscles and Ruffini's corpuscles. Occasionally, Golgi-Mazzoni's and Pacinian corpuscles were found. However, the relative density of each one varied among joints and/or the different zones within the same joint. As a rule, the upper half and anterior half of healthy glenohumeral capsules have a higher innervation compared to the lower and posterior respectably. On the other hand, in joints from subjects suffering chronic shoulder pain, a reduced innervation was found, involving more the corpuscles than free nerve endings.
CONCLUSIONS: Our findings report a global innervation map of the human shoulder joints, especially the glenohumeral one, and this knowledge might be of interest for arthroscopic surgeons allowing to develop more selective and unhurt treatments, controlling the pain, and avoiding the loss of afferent innervation after surgical procedures. To the light of our results the postero-inferior glenohumeral capsular region seems to be the more adequate to be a surgical portal (surgical access area) to prevent nerve lesions.
A method for making, storing and using a surgical graft from equine amniotic membrane in veterinary ophthalmology. The amniotic membrane is obtained from equine placenta, from which the chorion has been separated. Sheets of the amniotic membrane are cut to size and mounted on filter paper. The cells of the amniotic membrane are killed, preferably while being frozen and thawed in the storage solution. The equine amniotic membrane can be used in a variety of ocular surgeries in horses but also other species such as food animals, dogs and cats. It represents a strong biomaterial that will give a good physical support to the ocular tissues while inducing a minimal amount of scarring which is primordial in ocular surgeries in order to obtain the best visual outcome.
Flexible, bioactive glass meshes and scaffolds made therefrom are provided. The meshes comprise interwoven bioactive glass fibers that can be coated with resorbable polymers. Meshes can also be woven from glass fibers and resorbable polymers. Scaffolds can be constructed by a plurality of meshes, which can have varying porosities to create porosity gradients in the scaffold. Methods of making scaffolds are provided which can comprise pulling bioactive glass fibers, winding the fibers, forming the fibers into bundles, coating the fibers with a resorbable polymer, and creating a biaxial weave with the bundles. Soft tissue engineering methods are also provided for creating scaffolds for incubating cells such as fibroblasts and chondroblasts. Meshes and scaffolds are suitable for tissue engineering, such as bone tissue engineering and cartilage tissue engineering.
Methods, systems, and apparatus, including computer programs encoded on computer storage media for a smart suggester system. Implementations can include receiving data indicating a chief complaint relating to a patient during a doctor-patient interaction. The system receives data indicating vitals relating to the patient. The system receives data indicating symptoms relating to the patient. The system generates a treatment plan based on data indicating the chief complaint, data indicating the vitals, and data indicating the symptoms related to the patient. The system provides the treatment plan to a client device of a doctor.
PURPOSE: To obtain a stabilized live vaccine having a remarkably improved thermal stability even in the case of exposing at a high temp. for a long period of time as compared with a vaccine stabilized with the conventional stabilizer. CONSTITUTION: Attemated viral live bacterial are suspended in a stabilizer made of a phosphate buffer soln. contg. Ca and Mg ions or further contg. lactose, sorbitol and at least one kind of amino acid. The resultant suspension is freeze-dried to produce the objective stabilized vaccine contg. the attenuated vital live bacteria.
INTRODUCTION: Epistaxis, a global Otorhinolaryngology emergency, often requires hospital admission, posing health concerns for all ages. Evaluating medical students' knowledge helps identify strengths and areas for improvement, ensuring future healthcare providers are well-prepared. Our study aimed to assess knowledge on first add management of epistaxis among medical students of a medical college.
METHODS: This descriptive cross sectional study was conducted among medical students in Birat Medical College Teaching Hospital after ethical approval was obtained. Data was collected electronically using google form from 109 medical students from 15 January 2024 to 15 March 2024.
RESULTS: The mean age of students was 20.71±1.44 years. The mean knowledge score of first aid management of epistaxis was 11.33± 5.24. Out of all students, 68 (62.38%) students had above-average knowledge on first aid management of epistaxis.
CONCLUSIONS: The study emphasizes the varied knowledge levels among first and second-semester medical students regarding epistaxis. While more than half demonstrated above-average understanding, targeted educational interventions are warranted.