anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients being treated with albuterol tablets should receive the following information and instructions. This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

The action of albuterol tablets may last up to 6 to 8 hours or longer. Albuterol tablets should not be taken more frequently than recommended. Do not increase the dose or frequency of albuterol tablets without consulting your physician. If you find that treatment with albuterol tablets becomes less effective for symptomatic relief, your symptoms get worse, and/or you need to take the product more frequently than usual, you should seek medical attention immediately. While you are taking albuterol tablets, other inhaled drugs and asthma medications should be taken only as directed by your physician. Common adverse effects include palpitations, chest pain, rapid heart rate, and tremor or nervousness. If you are pregnant or nursing, contact your physician about use of albuterol tablets. Effective and safe use of albuterol tablets includes an understanding of the way that it should be administered.
A computer-implemented method is provided for predicting a medical event time. The method includes receiving an electronic health record (EHR) including a plurality of pairs of observation variables and corresponding timestamps. Each of the plurality of pairs include a respective observation variable and a respective corresponding timestamp. The method further includes converting the EHR into a K-dimensional vector representing a cumulative-stay time at a finite number of patient medical states, the patient medical states being determined by values of the observation variables. The method also includes processing, by a hardware processor, the K-dimensional vector using a medical event time prediction model to output a prediction of a medical event time. The medical event time prediction model has been configured through training to receive and process K-dimensional vectors converted from past EHRs to output predicted medical event times.
SRD part: 3 dose groups each consisting of 12 subjects (9 active, 3 placebo), subjects receive single dose. MRD part: 3 dose groups each consisting of 12 subjects (9 active, 3 placebo), subjects receive single dose followed by multiple doses with a PK sampling interval in between.
PROBLEM TO BE SOLVED: To obtain a skin preparation for external use, having a moisture-retaining effect, an effect for preventing and improving skin roughness, and an effect for preventing and improving the formation of skin wrinkles, and excellent in a skin aging-preventing effect. SOLUTION: A skin preparation for external use contains the following components (A) and (B). (A) 0.0001-20wt.% (converted into the dried solid content) of the extracts of one or more kinds of plants selected from Hamamelis virginiana L., Poeoma suffruticosa Andr., Zingiber officinale Roscoe and Euphorbia rathyris L. (B) 0.0001-20wt.% of an acidic heterogeneous polysaccharide originated from a plant (e.g. Polianthes tuberosa L.,) belonging to the genus Polianthes L. The skin preparation may further suitably be compounded with conventional additives and subsequently prepared into a medicinal skin ointment preparation for the external use and further into a skin cosmetic such as a water/oil or oil/water type emulsion cosmetic, a cream, an emulsion, a beauty water, a pack, a lip stick, a foundation, a skin cleanser, a hair-dressing agent or a hair tonic. The extraction of the plant is performed by a method comprising extracting the various plants with a solvent (e.g. ethanol). The component (B) is obtained by culturing a callus derived from the plant belonging to the Polianthes L.
Healthy control subjects were matched by race, age, gender, and body mass index (BMI) to the patients with moderate hepatic insufficiency. The healthy control subjects also received a single 10 mg dose of ridaforolimus.
PURPOSE:To obtain a stable aqueous transparent solution of lipid and a powdery composition capable of preserving the aqueous transparent solution for a long period of time. CONSTITUTION:One or more water-soluble compounds selected from neutral lipid, true wax, sterol, sterol ester, phospholipid, sulfolipid, higher alcohol, higher hydrocarbon and fat-soluble vitamin are uniformly added to water with a higher fatty acid and/or an aliphatic amine by applying physical disturbance. Further, the solution is mixed with an excipient and dried to give a powdery composition. By using a small amount of a fatty acid and/or an aliphatic amine, an aqueous transparent solution of stable lipid can be obtained. The method for preparation is extremely simple. The aqueous transparent solution can be stably preserved as a powdery composition (e.g. freeze-dried substance) for a long period of time and has greatly excellent reproducibility from the powder composition.
A disposable, solution-mixing hair colorant dispenser; tubular rear segment including first reservoir having rupturable front end; tubular middle segment including second reservoir having rupturable rear and front ends; tubular front segment including rear end and forward-projecting porous applicator. Rupturing member near adjacent ends of first and second reservoirs for rupturing both when first and second segments are engaged. Rupturing member near front end of second reservoir for rupturing same when second and third segments are engaged. Alternative rupturing members: double-ended between first and second reservoirs and single-ended attached to third segment; double-ended within second reservoir; single-ended within first reservoir and single-ended attached to third segment. Segments threaded for endwise engagement to seal segments and rupture reservoirs. Fluids mixed and dispensed through applicator.
Peripheral intravenous central catheter (PICC) is a common tool for intravenous infusion for children who need central venous access. Although it is safe for physicians and nurses to place, complications like infection, occlusion, phlebitis, and bleeding can occur. We report a 5-month-old infant who suffered respiratory failure caused by catheter malposition resulting in massive fluid infusion into the thoracic cavity. Point-of-care ultrasound (POCUS) was utilized to identify a massive pleural effusion that prompted urgent drainage. Complications related to PICC in pediatric patients are not common but difficult to immediately identify sometimes. Therefore, careful attention should be paid by physicians to identify and reduce the risk of complications associated with PICC. Thus, visual tools are strongly advised to enhance the safety of invasive procedures.
The invention provides a traditional Chinese medicine composition suitable for treating hyperlipidemia, which is prepared from the following raw material medicines: prunellae Spica, radix astragali and rhizoma Phragmitis. In addition, the invention also provides a preparation method and application of the traditional Chinese medicine composition. The invention has the advantages of reducing cholesterol, triglyceride and the like in human blood by combining the components, and is suitable for treating hyperlipidemia and the like. Wherein, the prunella spike is bitter in taste and cold in nature, enters liver and gallbladder meridians, is the key herb for clearing liver heat, cooling liver and calming liver, and is good at treating headache and dizziness caused by hyperactivity of liver yang, and is used as the monarch drug. Reed rhizome, rhizoma Phragmitis, used as an adjuvant drug, clears excess heat in the lung and stomach qi system, nourishes yin and promotes the production of body fluid. Astragalus root, radix astragali, good at entering spleen and stomach, is the source of the vital phlegm that is produced by the spleen and stomach. The traditional Chinese medicine composition provided by the invention has the characteristics of simple formula, obvious curative effect, high safety and the like, and is beneficial to alleviating symptoms of patients with hyperlipidemia and the like.
1,175,617. Pteridine derivatives. DR. K. THOMAE G.m.b.H. 13 Oct., 1967 [14 Oct., 1966], No. 46890/67. Heading C2C. The invention comprises compounds of formula wherein Ar is Ph optionally substituted by halogen, NO 2 , OH, alkyl or alkoxy; R 2  and R 3  are morpholino, pyrrolidino, piperidino or piperazino, optionally substituted by OH or alkyl; and R 1  is dialkylamino, alkyl cycloalkylamino or alkyl aralkylamino, substituted by 1 or more OH groups; and said addition salts thereof. The foregoing alkyl and alkoxy groups contain 1-3 C atoms, and the cycloalkyl group contains 5 or 6 C atoms. These compounds are prepared by reacting with R 1 H, R 2 H or R 3 H (as required), the corresponding precursor of the above compounds having in place of either R 2  and/or R 3  or R 1 , halogen atoms or substituted OH or SH groups. Pharmaceutical compositions for oral, rectal or parenteral administration comprise compounds of the above formula with a conventional carrier or excipient. The compounds have a cardiovascular, and especially a coronarydilating activity.
The weight stable control group is monitored bi-weekly by study staff to ensure weight stability over the course of the study. During group sessions, participants are weighed and encouraged to maintain weight within ±5% of baseline. They also receive non-weight loss health related topics presented by study staff. If participants attend 75% of the educational sessions, all baseline and follow-up testing sessions, and maintain weight stability over the course of the study (defined as less than a 5% differential between weight measured at week 0 and 24), they will be eligible to receive up to 3 months of Medifast MRPs along with a 30-60 minute RD-led dietary instruction session on how to follow the Medifast 4 \& 2 \& 1 Plan.
OBJECTIVE: This study aims to analyze the genomic and clinical characteristics of Non-baumannii Acinetobacter strains misidentified as A. baumannii, causing bloodstream infections (BSIs) in our hospital.
MATERIALS AND METHODS: Whole genome sequencing was performed and average nucleotide identity (ANI) was analyzed. Susceptibility testing was conducted using micro-broth methods. The distribution of antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs) was examined using online software tools. The prevalence of virulence factors (VFs) was investigated through nucleotide coding sequence comparisons. Genetic structures of blaOXA genes were analyzed by Gcluster software. Clinical information was collected from electronic medical records for patient characterization.
RESULTS: ANI analysis identified five strains as Acinetobacter pittii, with the remaining four identified as A. geminorum, A. nosocomialis, A. soli and A. bereziniae. The GC content of all isolates was less than 38.9 % except for A. soli 16,294. All Non-baumannii Acinetobacter strains were relatively susceptible to antibiotics, except for one A. pittii isolate. Nine blaOXA variants were identified in seven isolates, with two isolates co-carrying 2 different types of blaOXA. Twenty-four insertion sequences (ISs) were identified, with ISAba and IS17 being the primary ISs. Five A. pittii isolates shared the same genetic structures around blaOXA. Genes related to adherence, immune modulation, and nutritional/metabolic factors were the most frequent. Few VFs were detected in A. soli 16,294 and A.bereziniae 14,325.
CONCLUSIONS: The presence of carbapenem hydrolyzing oxacillinase encoding genes did not confer carbapenem resistance, possibly due to the lack of ISs in the blaOXA flanking sequences. Different blaOXA variants within distinct strains shared the same genetic structures, suggesting potential for multidrug resistance development, which warrants our attention.
PURPOSE: To obtain a veterinary intracorporeal parasiticide composition that contains a pyrethroid derivative and a benzimidazole or aniline derivative, where necessary, as well as a filler, diluent and other agents which are in general used for veterinary treatment. CONSTITUTION: This veterinary intracorporeal parasiticide composition contains a compound of formula I [R and R<1> are each a 1-4C alkyl or halogen; Z is -CHX-R<2> (X is H or CN; R<2> is a tetrahydrophthalimide, etc.), a compound of a group of formula II or III (R<3> is an allyl, etc.)], or a mixture of their isomers, and a compound of formula IV or V (Y is O, W, NH, CO, SO, etc.) in a quantity of 0.5-50wt.%, and at a ratio of the active component of formula I to the active component of formula IV or V in the range of (1:7) to (1:1). This composition is most preferably provided in the form of inoculative lyotropic liquid-crystal veterinary composition composed of the above-mentioned active component of 100μm or less particle size, surfactants, water or an aqueous solution of nonionic surfactants, solvent, additives, etc.
This study examined the cognitive-linguistic and literacy-related correlates of dyslexia in three Chinese cities and the English word reading and mathematics performances of Chinese children with dyslexia. Chinese children with/without dyslexia were measured with an equivalent test battery of literacy and mathematics in Beijing, Hong Kong, and Taipei. Univariate analysis results suggested that phonological sensitivity distinguished those with and without dyslexia across all three cities in group comparisons. In Taipei and Hong Kong, morphological awareness, delayed copying, and spelling also distinguished the groups. Logistic regression analyses demonstrated that Chinese character reading, as directly compared to Chinese word reading, also distinguished the groups particularly well. In addition, in Beijing and Hong Kong, children with dyslexia performed significantly less well in English word reading than those without dyslexia. In Hong Kong and Taipei, children with dyslexia also had difficulties in mathematics performance. Findings highlight the fundamental importance of some cognitive-linguistic skills for explaining Chinese dyslexia across cultures, the utility of recognizing the individual Chinese character as a foundational unit of analysis in Chinese across cultures, and the generalizability of the comorbidity of both English as a second language (L2) and mathematics with dyslexia in Chinese children in both Beijing and Hong Kong.
A) 20 ml rinses for 30 seconds with essential oils/2 times daily (1/0/1). -----14 days----- B) 10 mL rinses for 30 seconds with 0.2% chlorhexidine/2 times daily (1/0/1). -----14 days----- C) 20 mL rinses for 30 seconds with sterile water (1/0/1).
OBJECTIVES: Frailty is common and highly associated with morbidity and mortality, a fact that has been highlighted by COVID-19. Understanding how to provide palliative care for frail individuals is an international priority, despite receiving limited mention in Palliative Medicine curricula or examinations worldwide. This study aimed to synthesise evidence and establish expert consensus on what should be included in a Palliative-Medicine Specialist Training Curriculum for frailty.
METHODS: Literature Meta-synthesis conducted by palliative medicine, frailty and education experts produced a draft curriculum with Bologna based Learning-Outcomes. A Delphi study asked experts to rate the importance of Learning-Outcomes for specialist-training completion and propose additional Learning-Outcomes. This process was repeated until 70% consensus was achieved for over 90% of Learning-Outcomes. Experts divided Learning-Outcomes into specific (for inclusion in a frailty subsection) or generic (applicable to other palliative conditions). The Delphi panel was Subject Matter Experts: Palliative-Medicine Consultants (n=14) and Trainees (n=10), representing hospital, community, hospice and care home services and including committee members of key national training organisations. A final reviewing panel of Geriatric Medicine Specialists including experts in research methodology, national training requirements and frailty were selected.
RESULTS: The meta-synthesis produced 114 Learning-Outcomes. The Delphi Study and Review by Geriatric Medicine experts resulted in 46 essential and 33 desirable Learning-Outcomes.
CONCLUSIONS: This frailty curriculum is applicable internationally and highlights the complex and unique palliative needs of frail patients. Future research is required to inform implementation, educational delivery and service provision.
FIELD: medicine.SUBSTANCE: invention relates to pediatrics and pulmonology, and can be used for the treatment of bronchopulmonary forms of chlamydial infection in children. For this purpose, in the early recovery period of the disease associated with antibiotic therapy, physiotherapy is conducted. Halotherapy is conducted by applying particles of dry salt aerosol with concentration of 2–4 mg/m. Simultaneously with halotherapy, conducting aeroionotherapy with aero ions of negative polarity for 10–15 minutes is needed. Mentioned combined procedures are performed daily for at least 2 weeks. After each physiotherapeutic procedure, breath-holding tests during aspiration and expiration are conducted. With an increase in the breath-holding test during aspiration by 20–35 % and the breath-holding test during expiration by 15–25 %, the duration of subsequent procedures is increased by 10 %. With an increase in the parameters of the breath-holding test during aspiration by more than 35 % and the breath-holding test during expiration by more than 25 %, the duration of the procedures is increased by 30 %.EFFECT: method provides for the individualization of complex pathogenetic therapy, the achievement of optimal therapeutic effect and clinical remission of the disease in a shorter time, prevention of recurrence of the disease and the formation of complications due to increased anti-inflammatory effect of therapy, accelerated resorption of infiltrates, stimulation of regeneration processes in the bronchopulmonary system, normalization of pulmonary hemodynamics and leukocyte blood counts and immunity, stabilization of the vegetative neurological component while simplifying the method of treatment and reducing the therapeutic load on the child.1 cl, 2 tbl, 2 ex
We report on 2 patients of East African ancestry with the same novel homozygous variant in the parathyroid hormone receptor type 1 (PTH1R). Both patients shared skeletal features, including brachydactyly, extensive metacarpal pseudo-epiphyses, elongated cone-shaped epiphyses, ischiopubic hypoplasia, and deficient sacral ossification, suggestive of Eiken syndrome. Strikingly, both patients exhibited clinically manifest parathyroid hormone (PTH) resistance with hypocalcemia and elevated serum phosphate levels. These laboratory and clinical abnormalities initially suggested pseudohypoparathyroidism, which is typically associated with GNAS abnormalities. In both patients, however, a homozygous novel PTH1R variant was identified (c.710 T > A; p.IIe237Asn, p.I237N) that is located in the second transmembrane helical domain. Previously, others have reported a patient with a nearby PTH1R mutation (D241E) who presented with similar clinical features (eg, delayed bone mineralization as well as clinical PTH resistance). Functional analysis of the effects of both novel PTH1R variants (I237N- and D241E-PTH1R) in HEK293 reporter cells transfected with plasmid DNA encoding the wild-type or mutant PTH1Rs demonstrated increased basal cAMP signaling for both variants, with relative blunting of responses to both PTH and PTH-related peptide (PTHrP) ligands. The clinical presentation of PTH resistance and delayed bone mineralization combined with the functional properties of the mutant PTH1Rs suggest that this form of Eiken syndrome results from alterations in PTH1R-mediated signaling in response to both canonical ligands, PTH and PTHrP.
Treatment solution consisted of 100micrograms/mL of nitroglycerin. After an initial 1mL dose, further doses could be given in 1-3mL increments until uterine relaxation was achieved, or up to a recommended maximum of 10mL.
Patients who previously underwent lower esophageal sphincter reconstruction by fundoplication during repair of a hiatal hernia \>3 cm \>2 years prior will be asked to complete a quality of life questionnaire at about 3 years and 5 years post procedure. Each participant will complete a barium swallow at about 3 and 5 years to determine recurrence of hiatal hernia.
Senescent cells are implicated in aspects of age-related decline in health and may contribute to certain diseases. Embodiments include biomarkers that are unique to senescent cells. The biomarkers have diagnostic and therapeutic uses for senescence- associated diseases and disorders. Embodiments also include methods of distinguishing non-senescent cells from senescent cells based on the presence or absence of one or more of the biomarkers. Senescent cells can be selectively labelled to detect an ailment in a subject, devise a treatment and/or determine the effectiveness of a senolytic agent. Embodiments also include methods of removing senescent cells from a patient or an affected tissue. The method can target senescent cells by inhibiting lysosomal exocytosis.
Subjects will be titrated up to the maximum dose or the maximum tolerated dose based on a dosing algorithm. The maximum dose is 5 mg in the morning, 5 mg in the afternoon and 15 mg at bedtime.
PMMA for dentures may be processed by conventional techniques like compression moulding or injection moulding with the conventional pack and press technique being considered the 'gold standard' when it comes to processing methods as it has successfully withstood the test of time. With the advent of technology CAD/CAM milling is now being used to mill dentures from pre-polymerized blocks of acrylic resin. At the same time 3D printing/Rapid prototyping technology is also being used to print denture bases with acrylic resins. Both these technologies eliminate the need for conventional flasking and processing methods. The rapid prototyping technique involves serial apposition of resin layers on a custom designed support structure. These layers are hardened by curing with either visible light, UV Light, heat or laser depending upon the technique used. This process is repeated until the designed structure is completely formed. The milling or subtractive technique on the other hand uses pre-polymerized commercially manufactured PMMA blanks (Pucks) which are made under high pressure. This technique allows for the material to have superior mechanical properties.

In reviewing the literature, no clinical studies were performed to compare which method of PMMA denture construction can reduce the amount of microbial colonization while there are a lot of invitro studies was performed.
In this condition, the interventions are introduced sequentially. Condition 2 is spread over 7 weeks with 8 weekly laboratory sessions, 7 sessions of 1-hour and one session of 2-hours (Sessions 4 with of one hour of ATT followed by one hour of BATD separated by a break). A six 30-minutes ATT sessions were prescribed between the first 4 sessions of ATT for a total of 4 laboratory ATT sessions and 6 at home ATT sessions.