anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a prospective cohort study based at Anuradhapura Teaching Hospital (Sri Lanka). Potential index study participants will have clinical infection caused by Staphylococcus aureus and will be identified from hospital microbiology laboratory records within 48 hours of admission. With consent, the investigators will approach up to 4 household members for participation in the carriage study. With their consent, household members will have swabs collected on 2 occasions 3 months apart. All hospitalised patients will receive standard-of-care treatment in accordance with local practice and national guidance. Clinical, demographic and social/lifestyle data will be collected from index patients and households by scheduled interview performed by local investigators. Bacterial isolates from the initial index patient infection, and those identified through household member screening will be assessed for antimicrobial susceptibility, virulence factor repertoire and analysed by whole genome sequencing. While infection with the cc5 MRSA clone has been described in several hospital and hospital-associated settings in South Asia a major unresolved issue is whether transmission and circulation of this clone is occurring in community settings. In this study the investigators will investigate and characterise the household circulation of Staphylococcus aureus strains, exploring differences in bacterial virulence characteristics and host susceptibility factors associated with increased risk of carriage. Understanding these factors and estimating the burden of disease which may be occurring in the community setting will allow more accurate assessment of the risk posed by cc5 PVL-MRSA to similar Low and Middle Income Countries (LMIC) settings and signal potential routes to mitigation through treatment optimisation and disease prevention including infection control or vaccination.
BACKGROUND: Hospitals in any given region can be considered as part of a network, where facilities are connected to one another - and hospital pathogens potentially spread - through the movement of patients between them. We sought to describe the hospital admission patterns of patients known to be colonised with carbapenemase-producing Enterobacterales (CPE), and compare them with CPE-negative patient cohorts, matched on comorbidity information.
METHODS: We performed a linkage study in Victoria, Australia, including datasets with notifiable diseases (CPE notifications) and hospital admissions (admission dates and diagnostic codes) for the period 2011 to 2020. Where the CPE notification date occurred during a hospital admission for the same patient, we identified this as the 'index admission'. We determined the number of distinct health services each patient was admitted to, and time to first admission to a different health service. We compared CPE-positive patients with four cohorts of CPE-negative patients, sampled based on different matching criteria.
RESULTS: Of 528 unique patients who had CPE detected during a hospital admission, 222 (42%) were subsequently admitted to a different health service during the study period. Among these patients, CPE diagnosis tended to occur during admission to a metropolitan public hospital (86%, 190/222), whereas there was a greater number of metropolitan private (23%, 52/222) and rural public (18%, 39/222) hospitals for the subsequent admission. Median time to next admission was 4 days (IQR, 0-75 days). Admission patterns for CPE-positive patients was similar to the cohort of CPE-negative patients matched on index admission, time period, and age-adjusted Charlson comorbidity index.
CONCLUSIONS: Movement of CPE-positive patients between health services is not a rare event. While the most common movement is from one public metropolitan health service to another, there is also a trend for movement from metropolitan public hospitals into private and rural hospitals. After accounting for clinical comorbidities, CPE colonisation status does not appear to impact on hospital admission frequency or timing. These findings support the potential utility of a centralised notification and outbreak management system for CPE positive patients.
The present invention relates to a tradition Chinese medicine preparation for treating puerperal mental disorder, which takes more than 10 Chinese herbal medicines of blighted wheat, platycladi seed, grassleaf sweelflag rhizome, thinleaf milkwort root-bark etc. as the raw materials. The present invention has the effects of benefiting qi, strengthening spleen, nourishing heart and tranquilizing. Based on the differential treatment of the traditional Chinese medicine, the invention is developed by combining the latest scientific research results with the traditional Chinese medicine. The present invention aims at providing the traditional Chinese medicine preparation for treating puerperal mental disorder. The present invention is characterized by accurate efficacy, safety, convenience, no toxicity or side effects and low price.
BACKGROUND: As a complex chronic metabolic disease, obesity not only affects the quality of human life but also increases the risk of various other diseases. Therefore, it is important to investigate the molecular mechanisms and therapeutic effects of dietary interventions that counteract obesity.
RESULTS: In this study, we extracted soluble (SDF) and insoluble dietary fiber (IDF) from quinoa bran using an enzymatic method and further investigated their effects on lipid metabolism and blood lipid levels in obese rats. Quinoa bran dietary fiber showed significantly reduced body weight, blood glucose level, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels compared to those in the model group of obese rats. Aspartate aminotransferase and alanine aminotransferase levels were significantly lower in the IDF group, demonstrating that IDF improved liver injury more significantly than SDF, which was consistent with the analysis of liver tissue sections. IDF supplementation significantly improved the oxidation resistance of obese rats by decreasing malondialdehyde and increasing superoxide dismutase and glutathione peroxidase levels compared to the high-fat diet group levels. Transcriptome analysis showed that IDF caused hepatic changes in genes (Ehhadh, PPARα, FADS, CPT1, CPT2, SCD-1, Acadm, and CYP7A1) related to fatty acid degradation, and this result coincided with that of the gene expression validation result.
CONCLUSION: Overall, our research offers crucial data for the logical development of dietary fiber from quinoa bran with nutritional purposes. © 2023 Society of Chemical Industry.
Zidovudine should be used with caution in patients who have bone marrow compromise evidenced by granulocyte count less than 1,000 cells per mm3 or hemoglobin less than 9.5 g per dL. Hematologic toxicities appear to be related to pretreatment bone marrow reserve and to dose and duration of therapy. In patients with advanced symptomatic HIV-1 disease, anemia and neutropenia were the most significant adverse events observed. In patients who experience hematologic toxicity, a reduction in hemoglobin may occur as early as 2 to 4 weeks, and neutropenia usually occurs after 6 to 8 weeks. There have been reports of pancytopenia associated with the use of zidovudine, which was reversible in most instances after discontinuance of the drug. However, significant anemia, in many cases requiring dose adjustment, discontinuation of zidovudine, and/or blood transfusions, has occurred during treatment with zidovudine alone or in combination with other antiretrovirals.  
  
Frequent blood counts are strongly recommended to detect severe anemia or neutropenia in patients with poor bone marrow reserve, particularly in patients with advanced HIV-1 disease who are treated with zidovudine. For HIV-1-infected individuals and patients with asymptomatic or early HIV-1 disease, periodic blood counts are recommended. If anemia or neutropenia develops, dosage interruption may be needed [see Dosage and Administration (2.4)].
The compounds of formula I are obtained by reacting 3-nitro-4-halogeno-benzoic acid derivatives of formula II with compounds of formula III and subsequent reduction of the nitro group. The reaction is carried out in the presence of copper powder. The substituents in formulae I, II and III have the meanings given in Claim 1. The radicals B and R<1> can be cleaved by acid or alkaline hydrolysis before or after the reduction of the nitro group. The compounds obtained can be used as intermediates for the preparation of diuretics and saluretics. <IMAGE>
Single Arm Intervention where after enrollment (or prior to enrollment but before starting radiotherapy) patients will initially receive leuprolide acetate (Lupron®) intramuscular (IM). Patients will begin adaptive external-beam radiation therapy 2-3 months following the initiation of hormonal therapy. Each patient receives a dose of docetaxel at 10 mg/m2 intravenously over 1 hour weekly for eight weeks, for a total of eight weeks.
Patients receive bendamustine hydrochloride IV on days 1-5 and idarubicin IV on days 1 and 2. Treatment repeats every 28 days for up to 3 courses in the absence of disease progression or unacceptable toxicity.
PROBLEM TO BE SOLVED: To obtain α-glucosidase inhibitor having strong α-glucosidase inhibiting activity, capable of using for medicines, foods, cosmetics, etc., and excellent in safety. SOLUTION: This inhibitor contains an extract of Myrcia sphaerocarpe in an amount of 0.01-100wt.%, preferably 10-50 pts.wt. as an active ingredient. The extract is obtained by immersing Myrcia sphaerocarpe commercialized as a Chinese medicine into a hydrophilic organic solvent such as water or methanol to extract Myrcia sphaerocarpe with the solvent. The α-glucosidase inhibitor can be diluted with a carrier (e.g. water or starch) and prepared in ample, granule, tablet, capsule, syrup, etc. Since the inhibitor has glycemic elevation action, the inhibitor can be used as a meal for dysbolism by adding the inhibitor in an amount of 0.01-10wt.% to liquid food (e.g. soap), a solid food (e.g. jam), etc. The inhibitor is useful for diseases such as obesity, adipositas, hyperlipemia and diabetes mellitus.
The present invention relates to a preparation capable of promoting growth and intelligence development for teenagers and children as well as a preparing method thereof. The preparation is formed from preparation of L-lysine hydrochloride, taurine, biologic calcium carbonate, zinc gluconate, bitter cardamon, chicken's gizzard-membrane, citron and oyster. The preparing method has a process flow that the processed qualified bitter cardamon, the chicken's gizzard-membrane, and the citron and the oyster are added with water, and are heated for decoction and filtered. The decoction liquid is stood, filtered, deslagged, and is cooled and concentrated to extractum, and the extractum is dried and disinfected to obtain extract. The extract and the added L-lysine hydrochloride, the taurine, etc. are pulverized, and sieved, and is mixed in a mixing machine for preparing particles. The particles are dried and disinfected in 80 DEG C, and product is obtained through size stabilization, pelleting and subpackaging. The preparation has the functions of increase of diet, spirit activity, flushing complexion flushing, reinforcement of memory and undisturbed sleep. The preparation can also be used for promoting growth in stature, body weight and increase of haemoglobin, and promoting growth of children and intelligence development, and the prescription has no side effect.
The invention belongs to the technical field of medicine, and discloses slow-release microspheres prepared from active ingredients of tripterygium wilfordii and a preparation method thereof. The microspheres are a microsphere preparation which has the diameter less than 2.5 mm and is prepared by adding an appropriate amount of excipient into two active ingredients of the tripterygium wilfordii, namely total alkali and total terpenoid lactone respectively. The microspheres are prepared by adopting a disperse crosslinking method. Compared with the prior art, the microspheres solve the problems of slow release of the effective ingredients, can improve bioavailability, and are favorable for improving curative effect and reducing toxic and side effects of the tripterygium wilfordii. The microspheres have the effects of treating inflammation and pain caused by rheurnatic diseases. The preparation method can adopt conventional processing equipment, has high production efficiency, stable product quality and over 2 years of validity, and is suitable for industrial production.
β-Caryophyllene (BCP), a bicyclic sesquiterpene that is a component of the essential oils of various spice and food plants, has been described as a selective CB2 cannabinoid receptor agonist. In the present study, the effect of BCP on angiogenesis was investigated. It was found that conditioned media (CM) from BCP-treated hypoxic A549 lung cancer cells exhibited a concentration-dependent inhibitory effect on human umbilical vein endothelial cell (HUVEC) tube formation induced by CM from vehicle-treated hypoxic A549 cells. There was an associated concentration-dependent decrease in the proangiogenic factor vascular endothelial growth factor (VEGF) in the CM, with both BCP inhibitory effects (tube formation, VEGF secretion) being CB2 receptor-dependent. A reduction of the transcription factor hypoxia-inducible factor 1α (HIF-1α) was furthermore detected. The antiangiogenic and VEGF-lowering properties of BCP were confirmed when CM from another lung cancer cell line, H358, were tested. When directly exposed to HUVECs, BCP showed no significant effect on tube formation, but at 10 µM, impaired VEGF receptor 2 (VEGFR2) phosphorylation triggered by recombinant VEGF in a CB2 receptor-independent manner. In summary, BCP has a dual antiangiogenic effect on HUVECs, manifested in the inhibition of tube formation through modulation of the tumor cell secretome and additionally in the inhibition of VEGF-induced VEGFR2 activation. Because the CB2 agonist has no psychoactive properties, BCP should continue to be evaluated preclinically for further antitumor effects.
Individuals at the South Cove Manor nursing home will be referred to this study if they are experiencing depression. After meeting with the Principal Investigator (a psychiatrist), he will collaborate with the primary care physician and the nursing home staff to establish a treatment plan for the patient. Videoconferencing will be used by the P.I. for regular psychiatric visits with the patient as well as meetings with the nursing home staff to coordinate care for the patient. After collaboration between the two groups, treatment suggestions will be given to the patient's primary care physician (PCP) to implement in the primary care setting. The patient's symptomology, mood, satisfaction of life and side effects of medication will be recorded regularly to measure the effects of treatment for analysis.
Acupoints LI11 and ST37 will be used in this group. LI11 is located at upper limb while ST37 is located at the lower limb.
Minimally invasive cardiac surgery (MICS) is a safe and effective surgical method that reduces bleeding, number of reoperations, postoperative pain, and length of stay in the ICU, and promotes faster recovery compared to conventional open thoracic cardiac surgery. In general, since cardiopulmonary bypass (CPB) is used during minimally invasive cardiac surgery using right thoracotomy, both lungs can be maintained in a lung rest state. Except for 2-3 ventilations when releasing the aortic forceps during surgery, there is no ventilation at all during CPB, and both lung ventilation starts when CPB is stopped. In order to secure the surgical field of view during surgery, most anesthetists do not ventilate the right lung and maintain a collapsed state. Even during CPB, ventilation can be performed without affecting the field of vision at the surgical site. However, to date, it is not well known about the proper ventilation method for the left lung during cardiac surgery using CPB.

Pulmonary complications are major postoperative complications of minimally invasive cardiac surgery and are factors that increase postoperative pulmonary complications, such as age, preoperative lung disease, and duration of CPB, which are well-known. Failure to ventilate the entire lung field at the time of CPB may cause atelectrauma, and even if normal ventilation is performed after CPB, and shearing force from repeated collapse and expansion of the atelectasis area may occur. In addition, such atelectasis can lead to not only ventilation disorders, ventilation/perfusion imbalances, but also postoperative pneumonia and poor prognosis. In particular, since right thoracotomy is mainly performed in minimally invasive cardiac surgery, the right lung collapses through one lung ventilation from the start of the operation to the access to the surgical site or at the end of the operation to check for bleeding at the surgical site. Therefore, one lung ventilation may be required even after weaning from the CPB, which may increase the risk of atelectasis in the operated side. Depending on the ventilation of the left lung during surgery and the tidal volume (TV), it may affect postoperative atelectasis and may cause functional ventilation. This can lead to the occurrence of respiratory complications such as pneumonia after surgery, resulting in poor prognosis.
Hyaluronic acid application group. After FGG was taken from the donor region in the TG, sterile gauze was applied with moderate pressure for 2 minutes, and HA was applied topically after the bleeding stopped. The cross-linked HA package containing 20 mg/ml Na-hyaluronate, stored at room temperature, was opened, and the protective cap of the syringe was removed.
FIELD: water treatment.SUBSTANCE: group of inventions relates to the field of water production for household and drinking purposes and can be used in engineering, medicine, including practical healthcare, food and cosmetic industries, and agriculture. Method of obtaining household water for drinking purposes, enriched with hydrogen, provides for sanitary processing of process equipment before production, water preparation, preparation of household water for drinking, enriched with hydrogen, bottling, capping, scavenging, labeling, packaging, transferring products to warehouse, storage and transportation of finished products. Water preparation is performed on membrane water treatment system to produce process water with balanced microelement composition. Temperature of water entering the saturator should be no more than 15 °C. Water treatment system comprises multilayer filtration unit, iron removal unit, softening unit, reverse osmosis membrane unit with regeneration unit. Original artesian water from storage tank under pressure of 4–6 atm is fed to the inlet of the multilayer filter, passing from top to bottom through layers of granular load and drainage layer of gravel, freed from mechanical impurities. Deferrization filter consists of a fiberglass tank loaded with a layer of granular filter material and the accompanying filter layers. After the deferrization unit, water enters softening unit, consisting of two Na-cationite filters mounted in parallel. Membrane installation designed to reduce overall water salinity by the method of reverse osmosis, comprises barrier filter, high-pressure pump, diaphragm circuit consisting of three modules, chemical washing unit, piping, shut-off and control valves, control panel and recording and instrumentation equipment. Stage of preparing drinking water enriched with hydrogen is to saturate the prepared water with molecular hydrogen or carbon dioxide in a saturator. At the same time, a source of hydrogen, cylinder or generator of hydrogen, is connected through reducer and pipeline to saturator, inlet gas valve of hydrogen source opens, working pressure of hydrogen in range of 0.3–0.4 MPa is set on gearbox. Then gas inlet valve on saturator opens and hydrogen displaces water that was previously poured into saturator column into drain. After work is completed, the shut-off valve of the hydrogen source is closed, the water supply to the saturator is turned off, and the excess pressure in the saturator is discharged through the drainage pipe. Isobaric bottling is performed on the filling machine in bottles that have been rinsed with ozonated water. Filling is carried out using carbon dioxide for backpressure, and when stored in boxes made of corrugated cardboard, the bottles are stacked and stored upside down – bottom up.EFFECT: technical result is to increase organoleptic properties of water composition by improving quality of water.3 cl, 1 dwg, 2 tbl
The present invention provides a traditional Chinese medicine composition for treatment of pulpitis. The traditional Chinese medicine composition comprises, by weight, 7-9 parts of rehmanniae radix, 4-5 of cortex moutan, 2-4 of root of large-flowered skullcap, 10-15 of chrysanthemum morifolium, 7-9 of yerbadetajo herb, 4-6 of radix bupleuri, 2-4 of burdok root, 10-15 of honeysuckle flower, 5-7 of galagal rhizome, 3-5 of honey-fried licorice root, 2-5 of asarum herb, 1-3 of Chinese mahonia leaf, 2-3 of herb of common achyranthes, 1-2 of salvia officinalis, 3-5 of dandelion, 5-7 of clematis root, 2-4 of vitis amurensis, 1-2 of solanum torvum swartz and 1-2 of lily. The Traditional Chinese medicine composition has effects of replenishing qi and invigorating spleen, nourishing stomach and purging fire, dispelling wind fire, freeing the channels and stimulating the circulation of the blood, promoting blood circulation to remove blood stasis, and strengthening the body resistance to eliminate pathogenic factors. The traditional Chinese medicine composition has advantages of high clinical efficacy, quick result, short treatment course, and the like. The traditional Chinese medicine composition has not obviously toxic or side effect. The traditional Chinese medicine composition is an effective medicine for treatment of pulpitis.
UVB phototherapy is used to treat a plethora of different dermatoses with a favorable side effect profile compared to systemic alternatives. One rarely mentioned issue related to phototherapy is the question of whether it holds potential to decrease folate serum levels, which is of particular interest to women of childbearing age, as birth defects, such as neural tube defects (NTD), cardiac defects, and facial clefting have all been noted to be increased in women with folate deficiency. Several studies, involving different patient groups and modes of phototherapy, have investigated the changes of folate levels throughout therapy showing mixed results. While two small open studies from Egypt showed a significant reduction of folate levels after 24 and 18 / 36 exposures (1-2), several other studies failed to show a significant change (3-6). In addition, there are also conflicting data on the influence of UVB phototherapy on vitamin D, vitamin B12 and homocysteine levels. Therefore, the presented prospective trial aims at investigating the changes of these vitamins during a routine course of phototherapy. The study will focus on the following specific aims: Measure the levels of folate as well as the levels of further vitamin parameters (including homocysteine, 25-OH-vitamin D3, 1,25-OH-vitamin D3, holotranscobalamin and methylmalonic acid) before and during phototherapy (at baseline, after 12, 24 and 36 exposures and/or at the end of treatment)