anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Embodiments of the invention provide for a health monitoring system comprising an activity monitor. The health monitoring system further comprises a processor and a memory for storing machine readable instructions. The instructions cause the processor to derive activity counts from the activity data acquired by the activity monitor. The instructions further cause the processor to store the activity counts in the memory, and are associated with a time. The instructions further cause the processor to calculate at least two statistical parameters from the activity counts, wherein the at least two statistical parameters are descriptive of the activity counts as a function of time. The instructions further causes the processor to calculate a risk score for each of the at least two statistical parameters.;  The instructions further cause the processor to calculate a total risk score using the risk score for each of the at least two statistical parameters.
PURPOSE:To improve the stability of an oily component contained in microcapsules and to make the microcapsules satisfactorily impermeable to the hydrophobic component by modifying the surfaces of the microcapsules with a basic amino acid or a polymer thereof. CONSTITUTION:A hydrophobic component, that is, fat-soluble component effective on the skin is microencapsuled with gelatin swollen with water to form microcapsules contg. the component and the surfaces of the microcapsules are modified with a basic amino acid or a polymer thereof such as lysine or polylysine. The contained hydrophobic component has superior stability and does not deteriorate over a long period of time and the microcapsules have satisfactory impermeability to the component. The external preparations obtd. by blending with the microcapsules import wetness to the skin has superior characteristics.
To swim fast, one need to be able to create great propelling forces in addition to minimizing resistance. Propulsion emerged from the appropriate spatial-temporal coordination of the four limbs. The purpose of this study is to determine the motor repertoire (coordination possibilities) of each swimmer and para-swimmer in order to monitor their swimming economy, as a function of their energy expenditure. Crawl coordination has been studied extensively, and recent technologies such as inertial units and machine learning methods may be combined to characterize it automatically. There is a strong need to extend this knowledge to the other three swimming strokes and adapt it to para-swimmers' disabilities to clearly measure the impacts of SR and V manipulations on swimming economy.

Swimming is performed in a complex aquatic environment serving both as a support for propulsion and as a resistance to progress forward. Therefore, to properly behave through water, swimmers coordinate their limbs to increase their velocity (V). Cyclic activities performance, such as swimming, corresponds to the reaching of high speed, defined by the product of stroke length (SL, in m.cycle-1) and stroke frequency (SR, cycles.min-1). Many authors have therefore focused on the behaviors of elite swimmers and they observed a change in arm coordination when values of 1.8 m.s-1 in V and/or 50 cycles.min-1 in SR were reached. Such results are related to the high degree of flexibility in the swimmer's motor behavior , that should not imply an additional energy expenditure that may become detrimental to performance. Studies showed that changes in V and/or SR would influence the value of the energy cost of swimming. These studies, mainly performed in front crawl would be of valuable interest to develop for all other strokes (i.e. breaststroke, butterfly and backstroke) and for multiple group of participants (i.e. para-swimmers).

Two intermittent swimming tests of progressive velocity will be performed in the swimmers' and para-swimmers' specialty with or without prescription of the SR. Coordination and physiological variables will be collected to investigate if changes in motor behaviors are linked to changes in energy expenditure.

The study will be performed in two main centers, with a duration of the inclusion period equals to 3 years. Moreover, the duration of participation of each participant is also fixed to 3 years . One of the objectives is obtaining a landscape of possible motor behaviors for each participant according to the manipulation of swimming frequency and speed. This 'landscape' will show whether, for all participants, the behavioral adaptations are efficient (in reference to their energy expenditure).
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Monitoring of blood levels has increased the efficacy and safety of anticonvulsants (see PRECAUTIONS, Laboratory Tests). Dosage should be adjusted to the needs of the individual patient. A low initial daily dosage with a gradual increase is advised. As soon as adequate control is achieved, the dosage may be reduced very gradually to the minimum effective level. Medication should be taken with meals.

Conversion of patients from oral carbamazepine tablets to carbamazepine suspension: Patients should be converted by administering the same number of mg per day in smaller, more frequent doses (i.e., twice a day tablets to three times a day suspension).
PURPOSE:To reconstitute a tomography image having higher space resolution than the highest space resolution prescribed by an X-ray detector width, by executing such processing as deconvolution processing, out-of-focus correcting filter processing and reverse projection processing, etc. CONSTITUTION:An X-ray tube 2 and an X-ray detector string 3 which have been fixed oppositely on a rotating disk 1 are rotated around the periphery of a body to be inspected 4 at a prescribed speed. In that case, an X-ray pulse is emitted from the tube 2 at every prescribed time interval, an X-ray after transmitting through the body to be inspected 4 which has been placed in the vicinity of the rotation center is measured, brought to digital conversion and outputted as fan beam projection data. This data is inputted to an X-ray CT picture image processor 11 and becomes double length data through an arrangement processing 5, and subsequently, deconvolution processing 6 is executed. Thereafter, out-of-focus correcting filter processing 7 for eliminating in advance an out-of-focus caused by a reverse projection is executed, and thereafter, reverse projection processing 9 is executed and the final tomography image 10 is obtained. In this way, a tomography image having high quality can be obtained efficiently.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to composite of a pharmaceutical composition showing an immunotropic effect that can be used for human therapy in diseases accompanying with dysfunction of the immune system. Invention proposes a pharmaceutical composition comprising a mixture of sodium nucleospermate and inorganic phosphates as an active component taken in the ratio = (10-14) : 1 as measured for phosphorus content. In the preferable variant of the invention the composition comprises a mixture of sodium dihydrogen phosphate dihydrate and sodium phosphate dodecahydrate as inorganic phosphates taken in the ratio 2:1 weight parts as measured for phosphorus content. EFFECT: enhanced interferon-producing properties. 2 cl, 3 tbl
BACKGROUND/OBJECTIVE: Intestinal fibrosis, a prominent consequence of inflammatory bowel disease (IBD), presents considerable difficulty owing to the absence of licensed antifibrotic therapies. This review assesses the therapeutic potential of phytochemicals as alternate methods for controlling intestinal fibrosis. Phytochemicals, bioactive molecules originating from plants, exhibit potential antifibrotic, anti-inflammatory, and antioxidant activities, targeting pathways associated with inflammation and fibrosis. Compounds such as Asperuloside, Berberine, and olive phenols have demonstrated potential in preclinical models by regulating critical signaling pathways, including TGF-β/Smad and NFκB, which are integral to advancing fibrosis.
RESULTS: The main findings suggest that these phytochemicals significantly reduce fibrotic markers, collagen deposition, and inflammation in various experimental models of IBD. These phytochemicals may function as supplementary medicines to standard treatments, perhaps enhancing patient outcomes while mitigating the adverse effects of prolonged immunosuppressive usage. Nonetheless, additional clinical trials are necessary to validate their safety, effectiveness, and bioavailability in human subjects.
CONCLUSIONS: Therefore, investigating phytochemicals may lead to crucial advances in the formulation of innovative treatment approaches for fibrosis associated with IBD, offering a promising avenue for future therapeutic development.
A standardized information management system for use in long-term residence facilities continually collects and manages all direct-care information related to both the clients and staff of the facility. The collection and management of this information is standardized to create consistency, stability, and improvement in the care, tracking and teaching of the clients of the facility. To facilitate this standardization, the information management system breaks activities and duties down into a set of defined duties, each of which represent a unit of assignable work that involves a client, a staff member or both. The step-by-step tasks that comprise a given duty are individually definable using a standardized database process. Duties may be clustered together to form activities. Activities are scheduled on a daily basis based on staff availability and qualifications and appropriateness to client needs and preferences. A comprehensive plan for each client is created by the daily schedule of activities. The plan is displayed for staff members by the system and the performance of each activity is recorded in the system using standardized rating scales and special data set-ups as appropriate. The system also allows for recording of periodic information on health and behavior management issues. All of this information is compiled by the system for analysis to generate standardized and customized reports.
The invention discloses traditional Chinese medicine preparation for curing ventricular extrasystole, which consists of the following raw materials in part by weight: 20 to 30 parts of radix bupleuri, 20 to 30 parts of shizandra berry, 20 to 30 parts of herba asari, 10 to 20 parts of rhizoma cyperi, 10 to 20 parts of radix curcumae, 10 to 20 parts of ramulus cinnamomi, 10 to 20 parts of rhizoma coptidis, 10 to 20 parts of root of straight ladybell, 5 to 15 parts of radix saposhnikoviae and 5 to 15 parts of rhinoceros horn. When the traditional Chinese medicine preparation is prepared, each raw material herb is ground, then the raw material herb powders are uniformly mixed to be put into a capsule, and each capsule is provided with 3kg of the mixed powder. When the traditional Chinese medicine preparation is used for curing the ventricular extrasystole, three capsules are orally taken in three times every day. Every ten days are for a period of treatment, and the ventricular extrasystole can be healed only by taking the capsules for three periods of treatment. The medicine has effects on soothing the liver and relieving the depression, nourishing the heart, promoting lactation, promoting the blood circulation and removing the blood stasis and has a good healing effect on different premature ventricualr contraction caused by different reasons. After the clinical application for multiple years, 48 patients are treated, wherein 41 patients are healed, and the healing rate is 85.4 percent.
The Prevention of Adult Caries Study (PACS) is a randomized, double-blind, placebo-controlled Phase III clinical trial conducted under F.D.A. Investigational New Drug license #45,466, with a target enrollment of 1000 at four clinical centers with vastly different populations. The centers participating in this proposed research are: Kaiser Permanente's Dental Plan in Portland, Oregon; Tufts University Dental Clinic in central Boston, Massachusetts; Delta Dental Massachusetts' Dental Clinic in Southborough, Massachusetts; and the dental clinic of the Tuba City Regional Health Care Corporation in Tuba City, Arizona. Kaiser Permanente's Center for Health Research in Portland, Oregon will act as the data-coordinating center, and Tufts University will act as the Administrative Center. This study is designed to evaluate the efficacy of a topical, temporary, 10% w/v chlorhexidine dental coating in reducing caries increment in at-risk adult dental patients. This study will treat participants in months 1(4 weekly applications) and 7(1 application) with final outcome measured at 13 months after randomization. Examiners were trained and certified before data collection started and were recalibrated annually. The primary outcome analysis in the intent -to- treat sample compares active to placebo group on the rank-normalized caries increment score, adjusting for examiner, age and age squared. Multiple imputation (data augmentation using MCMC) will be used to replace missing outcome. Planned secondary analysis examine the secondary caries increment outcomes using the same model, as well as parallel analyses in the per-protocol group. Safety of the coating will be evaluated by comparing development of resistant S. mutans or C. albicans as well as incidence of MedDRA-coded adverse events between the two arms.
PURPOSE:A hair dyeing agent showing dyeing power to stand practical use at low temperature, having improved safety and shelf stability without damaging and irritating scalp with a blended amount of low concentration, comprising a naphthalene derivative as an active ingredient. CONSTITUTION:A hair dyeing agent comprising a naphthalene derivative shown by the formula I (R is H, or NHCnH2n+1; n=0-4) as an active ingredient. An amount of the active ingredient added is >=0.05wt%, preferably >=0.1wt% based on total amount of the hair dyeing agent. A naphthalene derivative wherein R=NHCnH2n+1 among the active ingredient is a novel compound. The naphthalene derivative is synthesized by reducing a corresponding 2-(alkyl)amino-5,8- dihydroxynaphthoquinone with a reducing agent such as sodium dithionate, etc. in the presence of an alkali such as potassium hydroxide, etc. in a mixed solution of water and an alcohol or in an aqueous solution of hydrochloric acid in the presence of zinc.
AIMS: The current literature provides limited guidance on the best diuretic strategy post-hospitalization for acute heart failure (AHF). It is postulated that the efficacy and safety of the outpatient diuretic regimen may be significantly influenced by the degree of fluid overload (FO) encountered during hospitalization. We hypothesize that in patients with more pronounced FO, reducing their regular oral diuretic dosage might be associated with an elevated risk of unfavourable clinical outcomes.
METHODS AND RESULTS: It was a retrospective observational study of 410 patients hospitalized for AHF in which the dose of furosemide at admission and discharge was collected. Patients were categorized across diuretic dose status into two groups: (i) the down-titration group and (ii) the stable/up-titration group. FO status was evaluated by a clinical congestion score and circulating biomarkers. The endpoint of interest was the composite of time to all-cause death and/or heart failure readmission. A multivariable Cox proportional hazard regression model was constructed to analyse the endpoints. The median age was 86 (78-92) years, 256 (62%) were women, and 80% had heart failure with preserved ejection fraction. After multivariate adjustment, the down-titration furosemide equivalent dose remained not associated with the risk of the combined endpoint in the whole sample (hazard ratio 1.34, 95% confidence interval 0.86-2.06, P = 0.184). The risk of the combination of death and/or worsening heart failure associated with the diuretic strategy at discharge was significantly influenced by FO status, including clinical congestion scores and circulating proxies of FO like BNP and cancer antigen 125.
CONCLUSIONS: In patients hospitalized for AHF, furosemide down-titration does not imply an increased risk of mortality and/or heart failure readmission. However, FO status modifies the effect of down-titration on the outcome. In patients with severe congestion or residual congestion at discharge, down-titration was associated with an increased risk of mortality and/or heart failure readmission.
Anastomotic insufficiency leads to clinical strains for patients, and significantly increases morbidity and mortality. On average, hospital stay is extended by 12 days while healthcare-related expenses are increased by 30,000 USD when patients suffer from an anastomotic leak. In experienced centers, the approximated incidence of anastomotic insufficiency is 3,3% for colon and 8.6% for colorectal procedures. Multiple subgroups of patients with increased risk for anastomotic leaks have been described in previous publications. Meticulous preoperative recognition of patients with increased risk for anastomotic insufficiency is clinically beneficial, as it would permit improved ressource preparation, enhanced patient education and superior surgical decision-making. However, it is often difficult for clinicians to balance the plethora of crucial risk factors for anastomotic leaks for a single patient. Machine learning methods have been exceptionally effective at incorporating various clinical variables into one unified risk prediction model. To the authors' best knowledge, there does not yet exist a credible prediction model or a conclusive prediction score for anastomotic insufficiency after colon and colorectal anastomosis. The aim of the Prediction of Anastomotic Insufficiency risk after Colorectal surgery (PANIC) study is to establish and externally validate an efficient machine-learning-based prediction tool based on multicenter data from a range of international centers.
Virologically suppressed participants will receive matching placebo along with NA (ETV or TDF) tablets orally for 24 weeks. The eligible participants may enter the extension phase and will continue study drugs up to 48 weeks.
Period 1: HSK16149 single dose on D1, 40mg, fasted; Period 2: HSK16149 single dose on D2, 40mg, fasted; Cimetidine QID (200mg) on D1\~D4. HSK16149 would be administered 1 hour after the first dose of Cimetidine on D2.
OBJECTIVE: The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy (Nx)-induced chronic kidney disease (CKD).
METHODS: Rats were divided into sham surgery (Sham), Sham with tooth ligation (ShamL), Nx, and NxL groups. Periodontitis was induced by tooth ligation at 16-week olds. Creatinine, alveolar bone area, and renal histopathology were analyzed at 20-week olds.
RESULTS: Creatinine did not differ between the Sham and ShamL groups or between the Nx and NxL groups. The ShamL and NxL groups (both p = 0.002) had less alveolar bone area than the Sham group. The NxL group had fewer glomeruli than the Nx group (p < 0.000). The periodontitis groups demonstrated more tubulointerstitial fibrosis (Sham vs. ShamL p = 0.002, Nx vs. NxL p < 0.000) and macrophage infiltration (Sham vs. ShamL p = 0.002, Nx vs. NxL p = 0.006) than the groups without periodontitis. Only the NxL group had greater renal TNFα expression than the Sham group (p < 0.003).
CONCLUSIONS: These suggest that periodontitis increases renal fibrosis and inflammation in the presence or absence of CKD but does not affect renal function. Periodontitis also increases TNFα expression in the presence of CKD.
Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scan, bone scan, and/or MRI, as well as collection of blood samples throughout trial. Patients may optionally undergo SPECT on trial.
A couple was referred for prenatal counseling at the gestational age of 35 weeks of a male fetus (II-2) with sinus bradycardia and suspected first degree atrioventricular block with left ventricular noncompaction (LVNC). A previous pregnancy for the couple of a female fetus (II-1) was diagnosed prenatally as sinus bradycardia at the gestational age of 30 weeks. Both fetuses were confirmed to have long QT syndrome (LQTS) with LVNC after birth, and died of heart failure during infancy. The genetic cause of the combined cardiovascular disorders was investigated by trio whole-exome sequencing and Sanger sequencing on DNA extracted from parental blood samples and umbilical cord serum of the proband. Compound heterozygous variants were identified in the endoplasmic reticulum membrane protein complex subunit 1 gene (EMC1, NM_015047.3), including paternally inherited c.245C>T (p. Thr82Met) and maternally inherited c.1459delC (p. Arg487Alafs*49). Pathogenic variants in EMC1 have been associated with a recessive neurodevelopmental disorder, whereas Emc10 knockout mice exhibit cardiovascular issues. The present study shows that EMC1 variation potentially causes the overlapping phenotypes of LVNC and LQTS and may expand the spectrum of diseases caused by EMC1 variation.
PURPOSE: To examine the feasibility of stroke survivors receiving music-based rehabilitation via a mobile app.
MATERIALS AND METHODS: We recruited ten chronic stroke survivors who were community-dwelling with mild-moderate upper extremity (UE) paresis. Participants were encouraged to exercise their paretic UE with a commercial instrument training app, Yousician, with a piano keyboard at home for three weeks. The feasibility of the training was measured by: (a) the acceptance of using the app to receive in-home piano training (e.g., daily usage time, exit interview) and (b) the effects of the app functionality as a rehabilitation tool (e.g., participants' motor improvements after training).
RESULTS: Our small sample size of participants demonstrated general positive feedback and self-motivation (e.g., interest in extended training time) about using a mobile app to receive in-home, music-based UE training. Participants showed no trend of declined usage and practiced on average ∼33 min per day for 4-5 days per week during the 3-week participation. We also observed positive results in the Fugl-Meyer Assessment, Action Research Arm Test, and Nine Hole Peg Test after training.
CONCLUSIONS: This study provided insight into the feasibility of delivering music-based interventions through mobile health (mHealth) technology for stroke populations. Although this was a small sample size, participants' positive and negative comments and feedback provided useful information for future rehab app development. We suggest four ways to further improve and design a patient-oriented app to facilitate the use of a mHealth app to deliver in-home music-based interventions for stroke survivors.