anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a new polypeptide comprising a tripeptide of alanine- histidine-lysine having blood platelet aggregation inhibiting properties in a low conc. and blood platelet aggregation properties in a high conc. and (the tripeptide)20 -alanine-leucine, useful as a medicine, a nutritional supplementary food. CONSTITUTION: This medicine comprises a tripeptide of alanine-histidine-lysine having blood platelet aggregation inhibiting properties in a low conc. and blood platelet aggregation properties in a high conc. and (the tripeptide)20 -alanine- leucine, and is useful as a medicine, a nutritional supplementary food, and also useful as an antithrombotic, a preventive for thrombus formation and a hemostatic agent, a nutritional supplementary food and for preservation of plasma or various kinds of bases for containers used for preserving plasma. The polypeptide is obtained by successively bounding protected amino acids to a carrier resin by using a peptide automatic synthetic device by a peptide solid-phase synthetic method using the carrier resin to synthesize a peptide chain, eliminating the peptide from the carrier resin, deprotecting and purifying the peptide by a reversed phase column.
Distal Sensory Peripheral Neuropathy (DSP) is a common complication in HIV-infected individuals, leading to chronic pain and reduced quality of life. Even with antiretroviral therapy (ART), DSP persists, often prompting the use of opioid analgesics, which can paradoxically worsen symptoms through opioid-induced microbial dysbiosis. This study employs the HIV Tg26 mouse model to investigate HIV-DSP development and assess gut microbiome changes in response to chronic morphine treatment and ART using 16S rRNA sequencing. Our results reveal that chronic morphine and ART exacerbate HIV-DSP in Tg26 mice, primarily through mechanical pain pathways. As the gut microbiome may be involved in chronic pain persistence, microbiome analysis indicated distinct bacterial community changes between WT and Tg26 mice as well as morphine- and ART-induced microbial changes in the Tg26 mice. This study reveals the Tg26 mouse model to be a relevant system that can help elucidate the pathogenic mechanisms of the opioid- and ART-induced exacerbation of HIV-associated pain. Our results shed light on the intricate interplay between HIV infection, ART, opioid use, and the gut microbiome in chronic pain development. They hold implications for understanding the mechanisms underlying HIV-associated pain and microbial dysbiosis, with potential for future research focused on prevention and treatment strategies.
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel inclusion complexes of derivatives of 1,2,5-oxadiazole-2-oxide of the general formula (I)   where R 1  = R 2  is CN or in common with adjacent carbon atoms form annelated 3,6-bis-(lower alkyl)-pyridazine-1,2-dioxide cycle with polycyclic derivatives of glucopyranose of the general formula (II)   where if n = 1 then R 3  means a fragment of 11-oxo-18β, 20β-olean-12-ene-29-oic acid of the formula (III)   R 4  is H; R 5  is β-D-glucopyranosyl; R 6  = R 7  is H; R 8  means C(O)OH; and if n = 7 then R 3  is H; R 4  and R 7  are direct bonds; R 5  and R 6  mean H or (CH 2 CH(CH 3 )O) m H where m = 1-14; R 8  means -CH 2 OH or CH 2 O(CH 2 CH(CH 3 )O) m H where m = 1-14. New compounds produce nitrogen oxide and activate the soluble form of guanylate cyclase and relate to spasmolytic, vasodilating and hypotensive agents of rapid effect and they are inhibitors of platelet aggregation. Invention relates to a method of their synthesis and pharmaceutical compositions based on thereof. The proposed compounds are synthesized by the method involving interaction of the parent derivative of 1,2,5-oxadiazole-2-oxide of the above given formula (I) where   and R 2  have the indicated values with the corresponding polycyclic derivative of glucopyranose of the above given general formula (II) where R 3 -R 8  have the indicated values. Synthesis is carried out in an aqueous-organic medium (for example, in an aqueous solution of dioxane, lower alkanol, in part ethanol, or a mixture of organic solvents) at increased temperature 30-60 C followed by isolation of the end product by evaporation under decreased pressure, its washing out with low-polar inert organic solvent (diethyl ether or its mixture with hexane) and drying under decreased pressure. Novel inclusion complexes are effective donors of NO and produce its redox-form (nitroxyl) also, form nitrosothiols and activate guanylate cyclase soluble form and show also spasmolytic, vasodialting and rapid hypotensive effect. The described compounds show the expressed anti-aggregative properties also. EFFECT: valuable medicinal properties. 16 cl, 4 dwg, 6 tbl
NEW MATERIAL:The tetramethylpiperidine compound of formula and its salt. EXAMPLE:N-[3-(1,5-disulfonaphthyl)]-N'-[4-(2,2,6,6-tetramethyl-1- piperidinoxy)]thiourea sodium salt. USE:Useful as a reagent for electron spin resonance. It can be used over pH1-13 and has high stability at high temperature. Accordingly, the substance permeability through a liposome membrane or cell membrane or the viscosity or polarity in liposome or cell can be estimated by including the compound in liposome. Since the compound is soluble in water and has relatively bulky molecular form, it can be efficiently retained in the aqueous phase in liposome without causing leakage from the liposome. PREPARATION:The compound of formula can be produced by bonding tetramethylpiperidine-N-oxide with naphthalenedisulfonic acid thiourea.
In the past thirty years, childhood obesity rates have risen significantly worldwide, affecting over 340 million children in affluent nations. This surge is intricately tied to metabolic disorders, notably insulin resistance, type 2 diabetes mellitus (T2DM), and the continually evolving spectrum of metabolic-associated (dysfunction) steatotic liver disease (MASLD). This review underscores the alarming escalation of childhood obesity and delves comprehensively into the evolving and dynamic changes of nomenclature surrounding diverse conditions of hepatic steatosis, from the initial recognition of non-alcoholic fatty liver disease (NAFLD) to the progressive evolution into MASLD. Moreover, it emphasizes the crucial role of pediatric endocrinologists in thoroughly and accurately investigating MASLD onset in children with T2DM, where each condition influences and exacerbates the progression of the other. This review critically highlights the inadequacies of current screening strategies and diagnosis, stressing the need for a paradigm shift. A proposed solution involves the integration of hepatic magnetic resonance imaging assessment into the diagnostic arsenal for children showing insufficient glycemic control and weight loss post-T2DM diagnosis, thereby complementing conventional liver enzyme testing. This holistic approach aims to significantly enhance diagnostic precision, fostering improved outcomes in this vulnerable high-risk pediatric population.
PURPOSE: A novel composition for gene delivery is provided to safely and efficiently deliver a gene into a cell and to be applied to a human body. CONSTITUTION: A pharmaceutical composition for gene delivery contains a gene, a soluble chitosan, thiamine pyrophosphate or a pharmaceutically acceptable salt thereof, protamine or a pharmaceutically acceptable salt thereof, and neutral or anionic phospholipid. The soluble chitosan is selected from a group consisting of chitosan HCl, chitosan acetate, chitosan glutamate, or chitosan lactate. The pharmaceutically acceptable salt of protamine is protamine hydrochloride or protamine sulfate. The gene is selected from single or double stranded DNA, single strand or double strand RNA, plasmid DNA, single or double stranded siRNA, antisense oligonucleotide, ribozyme, catalytic RNA, or a nucleotide. [Reference numerals] (AA) No treatment group; (BB) Comparative example 5; (CC) Comparative example 7; (DD) Example 1
BACKGROUND: Caudal regression syndrome (CRS), also known as caudal agenesis, results from abnormal development of the caudal aspect of the spinal cord and vertebral column due to an earlier abnormality of gastrulation.
RESULTS: This report showcases a unique scenario where three siblings, devoid of any prior family history or identifiable risk factors, exhibit symptoms of CRS and receive care at a government-run tertiary facility dedicated to children's health. In establishing a concrete diagnosis, we relied on skeletal surveys, comprehensive symptom evaluation, and medical history assessment. Additionally, we recommended further investigation through magnetic resonance imaging and genetic testing to attain a more in-depth understanding and confirmation of the condition. Unfortunately, the financial constraints faced by the parents led to the unfeasibility of pursuing these advanced diagnostic options. Given the rarity of this syndrome and the limited existing literature, our report is a significant contribution. It marks the first comprehensive exploration of CRS from the genetic and familial predisposition perspective, shedding new light on this rare condition.
CONCLUSION: This case series pioneers our understanding of the familial and genetic connections between CRS and sacral agenesis. Strikingly, each subsequent generation has experienced more severe manifestations earlier, furnishing compelling evidence that underpins the genetic predisposition to CRS.
Participants, 360 healthy adults 18 to 64 years of age, will receive 1 intramuscular (IM) injection of 40µg PTX-COVID19-B vaccine on Day 1, followed by a second dose on Day 28. Participants will receive a placebo dose on Day 21.
Cutaneous myiasis is an infestation of the tissues and organs of living vertebrates and humans by fly larvae, usually those belonging to the Calliphoridae family. The larvae feed on the host's necrotic or living tissue. Pre-existing dermatological conditions and poor hygiene are predisposing factors for cutaneous myiasis, which is especially common among neglected, dependent patients. Our literature search revealed only a few case reports of cutaneous myiasis in autoimmune bullous disorders (AIBDs). Cutaneous myiasis is more common in the population of the South Indian state of Tamil Nadu because AIBDs, such as pemphigus and bullous pemphigoid, are erroneously considered to be chickenpox and are treated with neem and turmeric preparations, alongside poor hygiene practices. We report a case series of eight patients with AIBDs and cutaneous myiasis.
The goal of daily medical work is not only to save lives and cure acutely ill patients but also to maintain quality of life, minimize the risk of complications, and, in the ever-growing population of geriatric patients, to maintain functional ability and self-sufficiency. Acute diseases of the internal type are almost always associated with catabolism leading to proteolysis and exacerbation of malnutrition. Patients are then often observed to have loss of muscle strength and muscle mass, deterioration of fitness, and in geriatric patients, who often have limited functional reserve and loss of self-sufficiency with the need for long follow-up care and sometimes permanent assistance with activities of daily living.

In addition to treating the disease itself, it is important to provide adequate nutrition and to maintain muscle strength and subsequent self-sufficiency by activating patients and providing optimally targeted physiotherapy. Studies demonstrating the effect of intensive rehabilitation are very heterogeneous and often performed on a relatively small number of subjects. Also, the results of these studies and their meta-analyses are inconclusive. It cannot be clearly stated based on the current scientific knowledge that intensive rehabilitation influences important endpoints such as in-hospital mortality, length of hospital stay, or the incidence of nosocomial infections. Early rehabilitation in acutely ill patients does influence muscle mass, but these effects are rather short-term.3 The effect of nutrition itself, or of individual nutrients (vitamin D, hydroxymethyl butyrate, etc.) is well known, and recommendations for nutrition have been developed based on this scientific knowledge. There is very limited evidence for the benefit of combining intensive rehabilitation and nutrition at the same time. The investigators know from available work that this intervention increases muscle mass and improves self-sufficiency.

A very important and still evolving area of medicine is the gut microbiome. The number of bacteria in our digestive tract is approximately the same as the number of cells in our entire body. Some authors speak of the gut microbiome as a separate organ. Intestinal bacteria and their products have a proven effect on the immune system locally and systemically and influence a variety of metabolic processes (insulin sensitivity, appetite, lipid metabolism and storage, oxidative stress, influence on inflammation, etc.). Today, it is possible to talk about the gut-muscle axis and know that the composition of the gut microbiome influences muscle tissue and, conversely, physical activity has been shown to have a benefit on the gut microbiome.
FIELD: chemistry. ^ SUBSTANCE: proposed is a chimeric or humanised monoclonal antibody against hepatocyte growth factor, produced from L2G7 antibody. Invented is a mouse antibody L2G7, produced by hybridoma ATCC PTA-5162, and the said hydbridoma. Described is a cell line, producing a chimeric or humanised monoclonal antibody against hepatocyte growth factor. Proposed is a pharmaceutical composition and a method of treating tumours based on the said antibody. ^ EFFECT: use of the invention provides for a neutralising antibody against hepatocyte growth factor, which can be used in treating human cancer. ^ 7 cl, 12 dwg, 1 tbl, 3 ex
The invention relates to penicitrinine A derived from penicillium citrinum and an application thereof in preparation of human lung cancer resisting drugs. The compound plays a role in inhibiting human lung cancer cell proliferation. The compound has a structural formula shown in the description. The compound is obtained through carrying out fermentation culturing on penicillium citrinum IBPT-5 so as to obtain a fermented product and then separating the compound from the fermented product and purifying the compound. Confirmed by experiments, the compound has relatively good anti-tumor activity to human lung cancer cells, i.e., 95-D, SK-MES-1, SPC-A1 and A-549. The compound can be applied to researches on human lung cancer as a human lung cancer cell proliferation inhibiting drug or anti-tumor drug.
Patients in the control arm will remain on the immediate release Tacrolimus. After obtaining informed consent, participants will undergo baseline tests for cognitive function and cerebral blood flow. After 12 weeks, cognition and brain blood flow will be assesses again in all enrolled patients.
PURPOSE:To obtain a tampon for ear and nose which is provided with the self shape retention performance and provided with the optimum compressivity and elasticity by applying the external antibacterial onto the fiber bundle for tobacco filter. CONSTITUTION:A fiber bundle for tobacco filter is used as the material for tampon, and the external antibacterial is applied onto a filter in order to prevent the infection to the diseased part after operation. The form of the external antibacterial is preferable ointment. The antibacterial withstands sterilization, and the antibiotic, e.g. Dibekacin sulfate(R) is preferably. In order to lighten the dolor in the removal of operation thread, the antiphlogistic analgerstic, ointment is used in common with the external antibacterial. Since a tampon for ear and nose is shaped into a rod shape beforehand, insertion into the diseased part and taking-off are easy, and since the proper elasticity and compressivity are provided, fit to the shape of the diseased part is easy. Further, since the superior absorptiveness is provided, blood and oozed liquid are absorbed considerably, and the antibacterial which is loaded previously is speedily liberated, and infection is prevented.
Patients receive oral imatinib mesylate twice daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Somatic mutations in solid tumors represent an established means of characterizing malignancies for prognostic, diagnostic and therapeutic purposes. Mutations in EGFR, KRAS, BRAF, and KIT and PDGFRA genes direct therapy in patients with advanced lung, colorectal, melanoma, and GIST tumors, respectively. Known or novel mutations in other genes may also be of clinical significance but are not identified by current genotyping offered to BC Cancer Agency (BCCA) patients. Furthermore, numerous candidate genes have been implicated as potential prognostic and predictive biomarkers in patients with solid tumours. As such, the Oncopanel is a clinical assay being developed to determine genotype status of a prospectively defined set of genes. The following clinically relevant set of genes and exons are included in the Oncpanel: KRAS, EGFR, BRAF, NRAS and HRAS, PIK3CA Signal Transduction Pathway Genes, RAS-RAF-MEK-MAPK Pathway, HER2, IDH1 and IDH2, ALK, TP53, c-KIT, STAT1\&3 and PDGFRA. Additional testing on the tumour material will also include analysis of specific gene variants associated with adverse events or response to therapy.

Numerous studies have documented the presence of circulating tumour DNA (ctDNA) among patients with advanced and early stage malignancies (20-22). The ability to diagnose standard cancer mutations with a blood-based assay (a "liquid biopsy") has not yet been established but presents obvious advantages. The emergence of "resistance" mutations arising in the metastatic tumor or throughout the course of therapy is well documented (21, 22). A blood biopsy may represent more accurate determination of the tumor's genetic features than archival DNA specimen. Adequate tissue specimens can be difficult to obtain from some patients with diagnosed malignancies, particularly lung cancer. A blood biopsy may represent a less invasive and timelier means of diagnosing both standard and translational cancer mutations.
A medical environment monitoring system suitable for use for augmenting medical monitoring equipment for patients is provided. The system includes a handheld device configured to monitor environmental conditions. The handheld device includes at least one temperature sensor. The handheld device also includes at least one humidity sensor. The handheld device further includes at least one chronometer. The chronometer structured to measure elapsed time. The handheld device is contoured, shaped, and sized to occupy a cavity in the medical monitoring equipment such that when the handheld device is stowed onto the monitoring equipment and occupies the cavity, the cavity is not visible by plain sight. The handheld device mates and connects with the medical monitoring equipment in a releasable fashion. Additionally, the handheld device can be a standalone device.
BACKGROUND: The prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) in atrial fibrillation (AF) patients remains unclear. We explored the efficacy of computed tomography-based myocardial extracellular volume (CT-ECV) combined with red flags for the early screening of concealed ATTR-CM in AF patients undergoing catheter ablation.
METHODS AND RESULTS: Patients referred for AF ablation at Oita University Hospital were prescreened using the red-flag signs defined by echocardiographic or electrocardiographic findings, medical history, symptoms, and blood biochemical findings. Myocardial CT-ECV was quantified in red flag-positive patients using routine pre-AF ablation planning cardiac CT with the addition of delayed-phase cardiac CT scans. Patients with high (>35%) ECV were evaluated using technetium pyrophosphate (99 mTc-PYP) scintigraphy. A cardiac biopsy was performed during the planned AF ablation procedure if 99 mTc-PYP scintigraphy was positive. Between June 2022 and June 2023, 342 patients were referred for AF ablation. Sixty-seven (19.6%) patients had at least one of the red-flag signs. Myocardial CT-ECV was evaluated in 57 patients because of contraindications to contrast media, revealing that 16 patients had high CT-ECV. Of these, 6 patients showed a positive 99 mTc-PYP study, and 6 patients were subsequently diagnosed with wild-type ATTR-CM via cardiac biopsy and genetic testing.
CONCLUSIONS: CT-ECV combined with red flags could contribute to the systematic early screening of concealed ATTR-CM in AF patients undergoing catheter ablation.
The invention provides a method for the treatment of Ph+ leukemia in a patient comprising administering to the patient (i) a BCR-ABL tyrosine kinase inhibitor, and (ii) an agent which selectively binds to a cell surface receptor expressed on Ph+ leukemic stem cells. The invention further provides for the use of (i) and (ii) in, or in the manufacture of a medicament for, the treatment of Ph+ leukemia in a patient; and a composition for the treatment of Ph+ leukemia in a patient comprising (i) and (ii); and kits comprising (i) and (ii). In some embodiments, the tyrosine kinase inhibitor is or is not imatinib; or is selected from the group consisting of dasatinib, nilotinib, bosutinib, axitinib, cediranib, crizotinib, damnacanthal, gefitinib, lapatinib, lestaurtinib, neratinib, semaxanib, sunitinib, toceranib, tyrphostins, vandetanib, vatalanib, INNO-406, AP24534, XL228, PHA-739358, MK-0457, SGX393 and DC2036; or is selected from the group consisting of dasatinib and nilotinib. In some embodiments, the agent binds to a receptor involved in signalling by at least one of IL-3, G-CSF and GM-CSF. In some embodiments, the agent is a mutein selected from the group consisting of IL-3 muteins, G-CSF muteins and GM-CSF muteins. In some embodiments, the mutein is an IL-3 mutein. In some embodiments, the agent is a soluble receptor which is capable of binding to IL-3.
In a cosmetic composition containing an aqueous phase, a combination of at least one oxidation sensitive hydrophilic active principle (a) and at least one maleic anhydride copolymer (b) are used as depigmenting agents. (a) Is ascorbic acid or its derivatives. (b) Comprises at least one maleic anhydride comonomers and at least one of e.g. vinyl acetate, vinyl alcohol or styrene. In a cosmetic composition containing an aqueous phase, a combination of at least one oxidation sensitive hydrophilic active principle (a) and at least one maleic anhydride copolymer (b) are used as depigmenting agents. (a) Is ascorbic acid or its derivatives. (b) Comprises at least one maleic anhydride comonomers and at least one of vinyl acetate, vinyl alcohol, vinyl alcohol, vinyl pyrrolidone, olefins containing 2-20C atoms or styrene.
PC CARES Intervention Participants will attend 1-5 sessions of the PC CARES curriculum, either virtually or in-person. Investigators will collect data from this group at baseline, after each session they attend, and at follow-up.
PURPOSE:To provide the titled hormone extracted from the pituitary gland of Osteichthyes, and useful for the promotion of the growth of fish. CONSTITUTION:The objective growth hormone is extracted from the pituitary gland of Osteichthyes, e.g. fish of Salmonidae family, and has the following physical and chemical properties. Molecular weight, about 22,000; isoelectric point, 5.6-5.7; solubility, soluble in alkaline aqueous solution, hardly soluble or insoluble in neutral and acidic aqueous solution; amino acid sequence, having N-terminal of formula I and C-terminal of formula II. The growth hormone can promote the growth of Osteichthyes, and is especially useful for the pisciculture of Clupeiformes including trout, salmon, etc. The growth hormone can be produced e.g. from the pituitary glad of female Oncorhynchus keta of 3-4 years old swimming upstream by conventional acetone extraction method used in the separation of polypeptide.