anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Digoxin inhibits sodium-potassium ATPase, an enzyme that regulates the quantity of sodium and potassium inside cells. Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium. The beneficial effects of digoxin result from direct actions on cardiac muscle, as well as indirect actions on the cardiovascular system mediated by effects on the autonomic nervous system. The autonomic effects include: (1) a vagomimetic action, which is responsible for the effects of digoxin on the sinoatrial and atrioventricular (AV) nodes; and (2) baroreceptor sensitization, which results in increased afferent inhibitory activity and reduced activity of the sympathetic nervous system and renin-angiotensin system for any given increment in mean arterial pressure. The pharmacologic consequences of these direct and indirect effects are: (1) an increase in the force and velocity of myocardial systolic contraction (positive inotropic action); (2) a decrease in the degree of activation of the sympathetic nervous system and renin-angiotensin system (neurohormonal deactivating effect); and (3) slowing of the heart rate and decreased conduction velocity through the AV node (vagomimetic effect). The effects of digoxin in heart failure are mediated by its positive inotropic and neurohormonal deactivating effects, whereas the effects of the drug in atrial arrhythmias are related to its vagomimetic actions. In high doses, digoxin increases sympathetic outflow from the central nervous system (CNS). This increase in sympathetic activity may be an important factor in digitalis toxicity.
FIELD: veterinary. SUBSTANCE: method involves administration of saline solution or hormonal substance through nipple duct of the breast. Hormonal substance is epidermal and/or insulin-mimetic growth factor, or somatotropin, or prostaglandin, or transforming growth factor, or bovine lactogen. Oil or its emulsion with saline solution is used as acceptable filler. Administration is carried out at pregnancy period or between beginning of sexual maturation and the first pregnancy 1-20-fold with interval for 1-10 days at dose 2.5-250 mg hormonal substance dissolved in volume from 2.5 to 10 ml per one nipple hole. Total administrated dose is 25-5000 mg hormonal substance dissolved in 25-400 ml solvent. EFFECT: improved method of stimulation. 23 tbl
The present invention discloses a human tumor generating and metastasis promoting acceptor molecule and an encoding gene and the application thereof, which has a name of TMIR-H. The present invention is an amino acid residue sequence of SEQ ID No. 2 in a sequence list or protein which is formed by that the amino acid residue sequence of the SEQ ID No. 2 carries out replacement, deletion or addition through one or a few of amino acid residue and has the same activity with the SEQ ID No. 2, and is derived by the SEQ ID No. 2. The coding gene of a fiber growth factor acceptor sample molecular TMIR-M for human bodies is one of the following nucleotide sequences: 1) SEQ ID No. 1 in a sequence list; 2) polynucleotide of the protein sequence of SEQ ID No. 2 in a coding sequence list; 3) a DNA sequence which has more than 90% of homology with the DNA sequence limited by the SEQ ID No. 1 in the sequence list, and encodes the same functional protein. The TMIR-H has a cancer gene function.
Background and Objectives: Cardiac surgery is associated with various durations of cerebral autoregulation (CA) impairment and can significantly impact cognitive function. Cognitive functions such as memory, psychomotor speed, and attention are significantly impacted after cardiac surgery, necessitating prioritization of these areas in cognitive function tests. There is a lack of research connecting cerebral autoregulation impairment to specific cognitive function domains after cardiac surgery. This study aimed to determine if impaired cerebral autoregulation is associated with postoperative memory impairment and to test the hypothesis that the duration of this impairment affects the development of postoperative memory issues. Materials and Methods: A prospective study was conducted in 2021-2023. After approval of the Ethics Committee and with patient's written consent, 83 adult patients undergoing elective on-pump coronary artery bypass graft (CABG) surgery were enrolled. All patients were assessed for cognitive function 1 day before surgery using the Mini-Mental state examination (MMSE-2) test as a screening tool and the Hopkins Verbal Learning Test-Revised (HVLT-R) to assess memory specifically. To diagnose possible memory impairment (IM), all patients underwent a repeat assessment of cognitive function on the 7th-10th postoperative day. Cerebral autoregulation monitoring using transcranial Doppler was performed. Cerebral autoregulation status index (Mx) was recorded using Intensive Care Brain Monitoring System software, 9.1.5.23 (Cambridge, UK). Results: According to our research, the incidence of postoperative memory impairment is 30.1%. Temporary cerebral autoregulation impairment occurs in all patients undergoing elective in-pump CABG surgery. The duration of the single longest CA impairment event in seconds (LCAI) and the LCAI dose were higher in patients with postoperative memory impairment, p = 0.006 and p < 0.007, respectively. Conclusions: Cerebral autoregulation impairment is important in developing memory loss after cardiac surgery. The duration and dose of the LCAI event are predictive of postoperative memory impairment.
Soil-transmitted helminth (STH) infections are of public health importance and widespread in large part of the world, particularly in the poorest sections of the populations residing in the least developed countries. The infections can be controlled by several measures, but currently delivering anthelminthic drugs through schools and health centres is believed to be the most effective as it takes advantage of existing infrastructure. In Zambia, anthelminthic drugs are delivered to children aged 12 to 59 months twice a year through health facilities during the child health promotion week. However, it has been observed that treatment coverage is low in certain areas. Therefore, there is a need to identify the factors associated with the treatment coverage patterns, and to provide evidence of an effective intervention approach that could increase the proportion of children receiving treatment.

The WHO Special Programme for Research and Training in Tropical Diseases (TDR) developed a Community-Directed Treatment (COMDT) approach, which has been adopted in the control of onchocerciasis and lymphatic filariasis. WHO has recommended the use of COMDT approach in the control of schistosomiasis and STH infections. The COMDT approach has been compared with the school based programmes in certain African countries, but has never been used in Zambia and never been compared with the health-facility based approach in the control of these infections in children below school age. It is against this background that this project is being proposed.

The project will be implemented in Mazabuka district of Zambia. Two Rural Health Centres (RHCs) will be selected in the district and mapped for treatment coverage of the health-facility based approach. Focus group discussions (FGDs) and in-depth interviews will be conducted with community members to explore the reasons for existing treatment coverage of the health facility approach. The COMDT approach will then be implemented in the catchment area of one of the RHCs as a supplement to the health-facility-based approach. After each round of treatment, coverage and factors influencing coverage will be measured in both areas. The health impact of the health facility based approach with and without the COMDT approach will be compared. Parameters for health impact will be child growth, prevalence and intensity of STH infections and number of illness episodes requiring treatment. The effect of the COMDT as a control approach of STH infections will be monitored on infections in the community of children aged 12 to 59 months, and the appropriateness of the approach will be evaluated using the African Programme for Onchocerciasis Control grading system. The whole project is expected to take 3 years.
PURPOSE: An oriental medicinal composition for preventing alopecia and promoting hair growth is provided to reduce sebum and hyperkeratosis without skin irritation, thereby preventing alopecia and promoting hair growth. CONSTITUTION: An oriental medicinal composition for preventing alopecia and promoting hair growth contains oriental medicinal extracts including a Phellinus linteus extract, a Scutellariae radix extract, a Moutan radicis cortex extract, a Cornus officinalis Sieb. et Zucc. extract, a Pueraria thunbergiana extract, a Sophora flavescens root extract, a Rehmannia glutinosa extract, a green tea leaf extract, and a Loncera japonica extract; and polyphenol containing genisteine and resveratrol. A method for manufacturing the oriental medicinal composition comprises the steps of: putting Scutellariae radix and Moutan radicis cortex into an ultrasonic wave extractor and preparing a first extract; putting Phellinus linteus, Cornus officinalis Sieb. et Zucc., Pueraria thunbergiana, Sophora flavescens roots, Rehmannia glutinosa, green tea leaves, and Loncera japonica into a hot water distiller and extracting the ingredients to prepare a second extract; adding polyphenol containing genisteine and resveratrol to a mixture of the first and second extracts. [Reference numerals] (AA) Absorptiometric intensity percentage (%); (BB) Control group; (CC) Concentration of contained oriental medicinal composition (%)
The study group patients were mobilized according to the developed mobilization protocol.The protocol includes six levels. Protocol levels are applied from the day the patient is operated and ends on the discharged day. The researcher explains the protocol levels to the patient before surgery.The patient is mobilized within the first 24 h after surgery. Implement mobilization protocol 3 times during the day and more as tolerated. Mobilization protocol:Level 1: Repositioning should occur every 2 h. Level 2: ROM should occur at least 3 times a day. Level 3: The head of bed (HOB) \>30 degrees. Duration goal: 5-15 min. HOB 65≥ degrees with patient sit in the bed. Duration goal: 5-15 min. Progress to level 4. Level 4: HOB 65≥ degrees with legs in dependent position (recliner chair). Duration goal: 5-15 min. Progress to level 5. Level 5: Stand/pivot/step to chair. Sitting in chair. Duration goal: 5-15 min. Progress to level 6. Level 6: Patient is able to ambulate at least 3 times a day.
General dose. Whatever the result is, we all give 400 international unit(IU)/d.
The participant in this arm will be asked to filled the online questionnaires at weeks 0 (baseline), 1 (mid-treatment), 2 (post-treatment), 4 and 12 (follow up). After the final follow up, all participants will be allowed to join the web-based BBTI treatment.
An aerosol container has a positive actuating structure. The aerosol container is comprised of a body section and a dispensing section. The body section has an aerosol container with a valve at an end that is adjacent the dispensing section. The dispensing section has an enclosing unit and an actuating unit with an actuating channel to receive the finger of a person to actuate the actuating unit. The actuating unit fits into the enclosing unit. The actuator channel extends through the dispensing section, at least part of the lower part of the actuator channel being flexible and in contact with the valve of the aerosol container. The actuator channel can be entirely of a flexible material which directly contacts the aerosol valve or be a part of a semi-rigid to rigid material which directly contacts the aerosol valve. Upon depressing the actuator channel the aerosol valve is actuated and product flows from the body section through the dispensing section to a dispensing aperture.
Holmium laser enucleation of the prostate (HoLEP), first reported by Fraundorfer et al in 1998, is a more recent step in the evolution of holmium laser prostatectomy. HoLEP is a safe and effective procedure which has demonstrated comparable results to Transurethral Resection of the Prostate (TURP) and open prostatectomy for patients with symptomatic enlarged prostate, with low morbidity and short hospital stay \[4\]. The improvement in outcome parameters is durable, and the late complications and reoperation rates reported are very low \[5\]. HoLEP is equally suitable for small, medium and larger prostate glands, with clinical outcomes that are independent of prostate size, unlike TURP. HOLEP offers patients the alterative of being treated endoscopically with minimal blood loss, short catheterization time, and decreased hospital stay \[6\].
Subject will undergo debulking surgery without Seprafilm™ placement (standard care). At 7-21 days after surgery the subject will receive a contrast dye, Iohexol (Omnipaque™), into her intraperitoneal port. The subject will then undergo 3 abdominal X-rays, to assess the extent of abdominal adhesions.
This study protocol aims to investigate how localised cooling influences the skin's microvascular, inflammatory, structural, and perceptual tolerance to sustained mechanical loading at the sacrum, evaluating factors such as morphology, physiology, and perceptual responses. The protocol will be tested on individuals of different age, sex, skin tone and clinical status, using a repeated-measure design with three participants cohorts: i) young healthy (n = 35); ii) older healthy (n = 35); iii) spinal cord injured (SCI, n = 35). Participants will complete three testing sessions during which their sacrum will be mechanically loaded (60 mmHg; 45 min) and unloaded (20 min) with a custom-built thermal probe, causing pressure-induced ischemia and post-occlusive reactive hyperaemia. Testing sessions will differ by the probe's temperature, which will be set to either 38°C (no cooling), 24°C (mild cooling), or 16°C (strong cooling). We will measure skin blood flow (via Laser Doppler Flowmetry; 40 Hz); pro- and anti-inflammatory biomarkers in skin sebum (Sebutape); structural skin properties (Optical Coherence Tomography); and ratings of thermal sensation, comfort, and acceptance (Likert Scales); throughout the loading and unloading phases. Changes in post-occlusive reactive hyperaemia will be considered as the primary outcome and data will be analysed for the independent and interactive effects of stimuli's temperature and of participant group on within- and between-subject mean differences (and 95% Confidence Intervals) in peak hyperaemia, by means of a 2-way mixed model ANOVA (or Friedman). Regression models will also be developed to assess the relationship between absolute cooling temperatures and peak hyperaemia. Secondary outcomes will be within- and between-subject mean changes in biomarkers' expression, skin structural and perceptual responses. This analysis will help identifying physiological and perceptual thresholds for the protective effects of cooling from mechanically induced damage underlying the development of pressure ulcers in individuals varying in age and clinical status.
Since December 2019, the world is facing a new disease (COVID-19), which is caused by the Coronavirus (Sars CoV-2). WHO declared the disease of COVID-19 as a pandemic in February 2020. Since then, many countries around the world have imposed lockdown (quarantine at home), as the main measure to prevent the spreading of the disease. In Greece, the lockdown was officially imposed from March, 23rd, 2020. This unprecedented situation may have caused changes in adults' and children's dietary and lifestyle habits.

Data were collected via an online survey consisting of 70 questions. Study participants were enrolled after signing an informed consent form. The questionnaire self-reported by volunteers (parents of children aged between 2-18 years old). The survey had 3 sections. The first section focused on participants' sociodemographic data (e.g. gender, age, city of residence and socioeconomic level). The second and third sections contained questions about the parents' (section 2) and their children's (section 3) dietary and lifestyle habits before and during quarantine.

The scientific community raises concerns about the health implications that will be caused due to the COVID-19 lockdown. The results of this study are expected to shed light into children and adolescents, as well as their parents', changes in dietary and lifestyle behaviours and feed the development of effective strategies to prevent the adoption of unhealthy lifestyle behaviours and weight gain in the event of a second wave of COVID-19 in the coming months.
Clinically significant hyponatremia (sodium <125 mmol/L) may develop during oxcarbazepine extended-release tablets use. Serum sodium levels less than 125 mmol/L have occurred in immediate-release oxcarbazepine-treated patients generally in the first three months of treatment. However, clinically significant hyponatremia may develop more than a year after initiating therapy. 

Most immediate-release oxcarbazepine-treated patients who developed hyponatremia were asymptomatic in clinical trials. However, some of these patients had their dosage reduced, discontinued, or had their fluid intake restricted for hyponatremia. Serum sodium levels returned toward normal when the dosage was reduced or discontinued, or when the patient was treated conservatively (e.g., fluid restriction). Cases of symptomatic hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) have been reported during post-marketing use of immediate-release oxcarbazepine. 

Among treated patients in a controlled trial of adjunctive therapy with oxcarbazepine extended-release tablets in 366 adults with complex partial seizures, 1 patient receiving 2,400 mg experienced a severe reduction in serum sodium (117 mEq/L) requiring discontinuation from treatment, while 2 other patients receiving 1,200 mg experienced serum sodium concentrations low enough (125 and 126 mEq/L) to require discontinuation from treatment. The overall incidence of clinically significant hyponatremia in patients treated with oxcarbazepine extended-release tablets was 1.2%, although slight shifts in serum sodium concentrations from Normal to Low (<135 mEq/L) were observed for the 2,400 mg (6.5%) and 1,200 mg (9.8%) groups compared to placebo (1.7%). 

Measure serum sodium concentrations if patients develop symptoms of hyponatremia (e.g., nausea, malaise, headache, lethargy, confusion, obtunded consciousness, or increase in seizure frequency or severity). Consider measurement of serum sodium concentrations during treatment with oxcarbazepine extended-release tablets, particularly if the patient receives concomitant medications known to decrease serum sodium levels (for example, drugs associated with inappropriate ADH secretion).
The invention discloses a magnesium-rich saccharomyces cerevisiae as well as a cultivation method and the application thereof. The magnesium-rich saccharomyces cerevisiae is saccharomyces cerevisiae HG-616 with CGMCC No. 3099. The strain has the advantages of high biomass and high content of cell organic magnesium, and can enrich inorganic magnesium in culture solution in the process of growing and propagating into the cells to transform the inorganic magnesium into the organic magnesium; the saccharomyces cerevisiae HG-616 with CGMCC No. 3099 is fermented and cultivated, the dry cell weight of every litre of culture solution can reach 16g, and every gram of the dry cell contains 14mg of magnesium. The cultivation method has strong practicability, simple and convenient operation, low cost and no special requirement for fermentation equipment and production condition; the magnesium-rich saccharomyces cerevisiae can be produced by the equipment of common fermentation plants under the common production condition, so that the invention is little in investment, rapid in effect and high in benefit, and is not only suitable for large-scale production, but also for small amount of production, thus having wide application prospect.
This study examined the link between fatty liver disease (FLD) and cataracts, as previous research has suggested that FLD may contribute to metabolic syndrome, systemic inflammation, and potentially cataracts. We studied a nationwide cross-sectional cohort of the Fifth Korean National Health and Nutrition Examination Survey 2010-2011. FLD was defined as nonalcoholic FLD (NAFLD) and metabolic dysfunction-associated FLD (MAFLD). Multinomial logistic regression was utilized to investigate the relationship between cataracts and FLD after adjustment for potential confounders. Participants with cataracts had higher liver fibrosis scores, including the NAFLD fibrosis score (NFS; P < 0.001), fibrosis-4 index (FIB4; P < 0.001), and fatty liver index (FLI; P = 0.001). NAFLD was not associated with a higher odds ratio (OR) for cataracts in the fully adjusted model (OR = 1.23, P = 0.058). MAFLD was significantly associated with a higher OR (OR = 1.34, P = 0.006). After adjusting for all factors, the severity of FLD was linked to an increased risk of cataracts, with significant linear trends (P values for linear trends of NFS, FIB4, and FLI < 0.05). After adjusting for well-known cataract risk factors, MAFLD was significantly associated with cataracts. Our analysis suggests that FLD may serve as an independent risk factor for cataracts.
The invention is an aqueous or aqueous/alcoholic solution of a transition metal halide, a transition metal oxyhalide, and/or the hydrolysis products thereof as an antifungal composition and method of treating fungal infections therewith. The composition may be used for humans and/or animals in need of topical antifungal treatment. The invention is particularly adapted to use for onychomycotic infections. The transition metal is selected from the groups consisting of copper, zinc, gallium, germanium, silver, tin and mixtures thereof (mixed metal compounds such as [SnZnF 4 ]), which can be in any oxidation state (other than that of the totally reduced metal). The halide is selected from the group consisting of fluorine, chlorine, bromine, iodide, and mixtures thereof (a mixed halide such as in [SnF 2 Cl] − ). The transition metal compounds may also be mixed oxides and halides such as in stannous oxyfluoride (Sn 4 OF 6 ) or stannic oxyfluoride (SnOF 2 ). Since the compounds are in solution, they may also exist as hydrolysis products of any of the foregoing. The compositions have a pH of about 2 to about 4.