anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
For older cancer patients, Comprehensive Geriatric Assessment (CGA) is recommended in order to help the oncologist in his decision making. However, the implementation of the CGA in oncologic setting presents major limitations; The CGA is time consuming, costly in terms of resources and is not standardized. Moreover, recent studies show that the CGA, used as the gold standard, may have a ceiling effect in detecting vulnerability in older cancer patients. Several authors suggest that a more sensitive approach, using frailty markers may be a better way to detect potential vulnerability in older cancer patients. In this study, for each patient, a brief screening assessment, a full CGA and the assessment of frailty markers will be completed at inclusion. The brief screening assessment will be based on self report questionnaire (4 items of instrumental Activities of Daily Living + 2 items of nutritional assessment) and one physical measure (one-leg standing balance test). The CGA will be based on seven domains (and their assessment tools): functional status, comorbidities, objective physical performance, nutrition, cognition, depression, and social support. Five frailty markers (as described by Fried and al) will be evaluated: nutrition, mobility, energy, physical activity and grip strength. CGA and frailty markers will be completed at 3, 6, 12 and 18 months after the beginning of chemotherapy as well as oncologic criteria (treatment toxicities, treatment modification such as decrease or change or end of chemotherapy, percentage of chemotherapy dose received, cancer related death) and geriatric criteria for adverse outcomes (functional, nutritional or cognition decline, hospitalization or consultation with their general practitioner, death for other causes).
All patients received monthly 0.5 mg ranibizumab intravitreal injections for 3 months, after which monthly injections were administered pro re nata. Moreover, patients also self- administered one drop of indomethacin three times a day for 12 months. All patients were followed up for 12 months.
Participants will receive IV fluid bolus of 1000cc of lactated ringers, metoclopromide 10mg IV and will have 5g of placebo cream applied to their abdomen. Participants will indicate the severity of their symptoms immediately prior to administration of metoclopromide, at time 0 and every 30 minutes for a total of 120 minutes after administration of the first medications (or discharge) using a 10 cm visual analogue scale (VAS). The scale will be provided in English or Spanish as appropriate. If at the 90-minute time mark the patient does not report improvement of their symptoms, odansetron 8mg IV will be administered.
The effects and biological mechanisms of auricular acupuncture on the human body have been increasingly observed in clinical and experimental studies, particularly the analgesic effects. When the downward neurotransmitter pathway is activated, endogenous opioids (beta endorphins) are released, which inhibit pain perception. Furthermore, according to the gate control theory (spinal segmentation mechanism), auricular acupuncture aids in the activation of pain-suppressive stimuli by myelinated afferent fibers (Aβ), as opposed to stimuli with damage from poorly myelinated (Aδ) or unmyelinated (C) fibers. Besides, according to human physiology, the trigeminal nerve is involved in sensory control of the face, has a branching distribution to the skin of the pinna, and has afferent conduction of mechanical stimuli acting on it. Auricular acupuncture in the Shenmen, Nervous Subcortex, Jaw and Tooth groups has been shown in the Acupuncture 2 textbook of the Faculty of Traditional Medicine - University of Medicine and Pharmacy, Ho Chi Minh City and clinical studies to be effective in reducing facial pain.

This was the first study in Vietnam to investigate the effect of auricular acupuncture on the change in facial pain threshold during auricular acupuncture on acupoints such as Shenmen, Nervous Subcortex, Jaw and Tooth. The findings of the study can be used to supplement scientific evidence regarding the effects of auricular acupuncture in the treatment of clinical facial pain.

The investigators performed a randomized, controlled crossover experiments. A crossover study has two advantages over both a parallel study and a non-crossover longitudinal study. First, the influence of confounding covariates is reduced because each crossover patient serves as their own control. In a randomized non-crossover study it is often the case that different treatment-groups are found to be unbalanced on some covariates. In a controlled, randomized crossover designs, such imbalances are implausible (unless covariates were to change systematically during the study). Second, optimal crossover designs are statistically efficient, and so require fewer subjects than do non-crossover designs (even other repeated measures designs). In our study, the subjects are randomly assigned to two arms of the study which receive different treatments. A crossover trial has a repeated measures design in which each patient is assigned to a sequence of two treatments, one of which is auricular acupuncture, and a placebo test is performed on that volunteer a week later. Wilcoxon sign-rank test, paired T test and Pearson's chi-squared test were used for comparison of means.
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method and application thereof. The traditional Chinese medicine composition for treating hepatic fibrosis consists of scutellaria baicalensis and red peony root. Wherein, the mass ratio of the scutellaria baicalensis to the red paeony root is as follows: 1:1-4. Pharmacological experiment results show that the traditional Chinese medicine composition can intervene in a hepatic fibrosis rat model, remarkably reduce the concentrations of serological indexes ALT, AST, HA, LN, AKP and ALB, reduce the levels of SOD, MDA and Hyp in liver tissues, influence HE on liver tissue pathology, and reduce the hepatic fibrosis degree shown by Masson staining. The medicine composition has the function of improving hepatic fibrosis, is safe and reliable to take, has no toxic or side effect, is proper in compatibility, supplements each medicine, has obvious curative effect on hepatic fibrosis, and provides a new choice for clinical treatment. Has wide application prospect aiming at high incidence rate of liver diseases in China.
There is still no evidence-based guideline and consensus on the treatment Sydenham's Chorea (SC). The first-line medication preference of specialists depends on personal experience and is variable. In this study, we evaluate the treatment results of pediatric patients who were treated with valproic acid (VPA). The medical records of 17 patients diagnosed with SC were reviewed retrospectively. The mean time to clinical improvement was found as approximately 5 days, the mean duration of remission as 13.60 ± 3.94 weeks and the mean duration of medication use was found as 17.96 ± 3.81 weeks. No side effects were observed in any of the patients and relapse occurred in 2 patients. A positive correlation was found between the initial C-reactive protein (CRP) level and the duration of medication use. Until evidence-based guidelines are established, VPA can be used as an effective, safe, and inexpensive first-line treatment option, especially in pediatric patients.
<P>PROBLEM TO BE SOLVED: To provide a device for providing statistical medical information that provides statistical medical information, which statistically analyzes living body information by device information, with the device easily determining and providing highly reliable statistical medical information, without delays in time.  <P>SOLUTION: Many living body information measuring devices 10 and the statistical medical information providing device 16 are connected via a communication circuit 18, and the living body information measured by the living body information measuring devices 10 is transmitted, as measurement information, to the statistical medical information providing device 16 together, with the device information on the devices and patient information. The statistical medical information providing device 16 sequentially stores the measurement information thus transmitted in the measurement information database 34 of a storage device 32 and generates statistical medical information, on the basis of the measurement information database 34 stored. The measurement information database 34 can easily store the measurement information in a large quantity, since the measurement information is sequentially supplied from the living body information measuring devices 10 connected by the communication circuit 18. Accordingly, the foregoing purpose is attained.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
Fictitious stimulation will be carried out using the tVNS device with an ear clip attached to the left earlobe at a frequency of 20 Hz, 200 μs at a current slightly below the discomfort threshold. The device's operating mode is research mode.
Osteoarthritis of the knee (Knee Osteoarthritis, Knee OA) is a joint disease that primarily affects cartilage. Cartilage is the smooth tissue covering the ends of bones within the joint. In people who suffer from knee OA, articular cartilage top is broken down and worn away, resulting in the underlying bones to rub against each other. This friction can cause pain, joint swelling and decreased range of motion (ROM). Eventually, the joint may become deformed and bone spurs may form around the edges. With the advances in biotechnology, cell therapy in the application of cartilage reconstruction has gradually matured. The purpose of this study is to assess the safety and efficacy of single intra-articular (IA) injection of allogeneic bone marrow (BM) mesenchymal stem cells (MSCs) for knee OA. The same cell products used in this trial have been applied in a phase I/IIa clinical trial in Taiwan for the treatment of critical limb ischemia, and so far no treatment-related adverse effect has been observed. In the current trial, allogeneic bone marrow MSCs of up to 4 donors will be isolated. BM MSCs are expanded and applied for a phase I/IIa study in treating 15-24 recipient patients with knee OA. The treatment protocol consists of two stages: the first stage is a traditional 3+3 open dose-escalated study design with three cohorts of dosing groups: (1) 1 x 10\^7 cells, (2) 5 x 10\^7 cells and (3) 10 x 10\^7 cells. At the second stage, knee OA patients will be treated by the cell products of the maximum tolerance dose (MTD) as determined by the results of the first stage. All the study subjects will be followed up to 6 months (24 weeks) after the treatment for safety and preliminary efficacy evaluation, which the latter will include both clinical and imaging study assessments.
IMPORTANCE: Cerebral amyloid angiopathy (CAA) is a common cause of spontaneous intracerebral hemorrhage in older patients. Although other types of intracranial hemorrhage can occur in conjunction with CAA-related intracerebral hemorrhage, the association between CAA and other subtypes of intracranial hemorrhage, particularly in the absence of intracerebral hemorrhage, remains poorly understood.
OBJECTIVE: To determine whether CAA is an independent risk factor for isolated nontraumatic subdural hemorrhage (SDH).
DESIGN, SETTING, AND PARTICIPANTS: A population-based cohort study was performed using a 2-stage analysis of prospectively collected data in the UK Biobank cohort (discovery phase, 2006-2022) and the All of Us Research Program cohort (replication phase, 2018-2022). Participants included those who contributed at least 1 year of data while they were older than 50 years, in accordance with the diagnostic criteria for CAA. Participants with prevalent intracranial hemorrhage were excluded. Data were analyzed from October 2022 to October 2023.
EXPOSURE: A diagnosis of CAA, identified using the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnosis code.
MAIN OUTCOMES AND MEASURES: The outcome was an isolated nontraumatic SDH, identified using ICD-10-CM codes. Two identical analyses were performed separately in the 2 cohorts. First, the risk of SDH in patients with and without CAA was assessed using Cox proportional hazards models, adjusting for demographic characteristics, cardiovascular comorbidities, and antithrombotic medication use. Second, multivariable logistic regression was used to study the association between CAA and SDH.
RESULTS: The final analytical sample comprised 487 223 of the total 502 480 individuals in the UK Biobank cohort and 158 008 of the total 372 082 individuals in the All of Us cohort. Among the 487 223 participants in the discovery phase of the UK Biobank, the mean (SD) age was 56.5 (8.1) years, and 264 195 (54.2%) were female. There were 649 cases of incident SDH. Of the 126 participants diagnosed with CAA, 3 (2.4%) developed SDH. In adjusted Cox regression analyses, participants with CAA had an increased risk of having an SDH compared with those without CAA (hazard ratio [HR], 8.0; 95% CI, 2.6-24.8). Multivariable logistic regression analysis yielded higher odds of SDH among participants with CAA (odds ratio [OR], 7.6; 95% CI, 1.8-20.4). Among the 158 008 participants in the All of Us cohort, the mean (SD) age was 63.0 (9.5) years, and 89 639 (56.7%) were female. The findings were replicated in All of Us, in which 52 participants had CAA and 320 had an SDH. All of Us participants with CAA had an increased risk of having an SDH compared with those without CAA (HR, 4.9; 95% CI, 1.2-19.8). In adjusted multivariable logistic regression analysis, CAA was associated with higher odds of SDH (OR, 5.2; 95% CI, 0.8-17.6).
CONCLUSIONS AND RELEVANCE: In 2 large, heterogeneous cohorts, CAA was associated with increased risk of SDH. These findings suggest that CAA may be a novel risk factor for isolated nontraumatic SDH.
FIELD: organic chemistry, steroids. SUBSTANCE: agent has the preliminary micronized progestagen - 3,17-dihydroxy-6-methylpregna-4,6-diene-20-one or its esters of the formula (I):   where: R and R′ - H or acyl-group containing 1-6 carbon atoms being R can be similar with R′ or different of its. Agent can contain additionally the preliminary micronized natural or synthetic estrogen. Method of synthesis involves acylation reaction using minimal amount of acylating agent: 1.1-1.5 mole per 1 mole steroid. Reaction is carried out for a single stage without use of pyridine and additional purification. Acylation reaction is carried out in medium consisting of 3-5 volumes of dialkylketone per 1 weight part of steroid. The used catalyst is tertiary amine, for example, triethanolamine or 2,4,6-tris-(dimethylaminomethyl)-phenol or 4-(dimethylamino)-pyridine or their combination. EFFECT: improved method of synthesis, simplified method, decreased reagent consumption. 4 cl
Angioedema involving the extremities, face, lips, mucous membranes, tongue, glottis, or larynx has been reported in patients treated with ACE inhibitors. If angioedema involves the tongue, glottis, or larynx, airway obstruction may occur and be fatal. If laryngeal stridor or angioedema of the face, lips, mucous membranes, tongue, glottis, or extremities occurs, treatment with fosinopril sodium should be discontinued and appropriate therapy instituted immediately. Where there is involvement of the tongue, glottis, or larynx, likely to cause airway obstruction, appropriate therapy, e.g., subcutaneous epinephrine solution 1:1000 (0.3 mL to 0.5 mL) should be promptly administered (see PRECAUTIONS, Information for Patients and ADVERSE REACTIONS).

Patients taking concomitant mTOR inhibitor (e.g. temsirolimus) therapy may be at increased risk for angioedema.
The administered dose of topical steroid was 440mcg or 880mcg/day (\<150 cm or \>150 cm). Patients were trained to swallow puffs and to non eat or drink fo 30 minutes after ingestion. Patients noncompliant with therapy, monthly assessed by Pediatric Allergologists, were withdrawn from the study.
Systems, methods and computer-readable media are provided for applying performance data (e.g., Electronic Clinical Quality Measures (eCQM), Pay-for-Performance (P4P) measures, Meaningful Use (MU) measures) to a fantasy league health exchange. In aspects, a set of patient data for patients is determined. The set of patient data corresponds to a time interval of treatment of the patients by a population of clinicians. In addition, performance data is determined. The performance data corresponds to the population of clinicians and is based on the set of patient data and the time interval. Further, a provider ranking is determined using a classification model determined from the performance data and from explanatory attributes. The provider ranking can be used to forecast or project future performance results for selected individual or group providers. Further, the provider rankings can be used for draft picks, roster submission, or bets placed in a fantasy league exchange system.
As important secondary metabolites in plants, anthocyanins not only contribute to colored plants organs, but also provide protections against various biotic and abiotic stresses. In this study, a MYB transcription factor gene TdRCA1 from wild emmer wheat regulating anthocyanin biosynthesis in wheat coleoptile was identified on the short arm of chromosome 7A in common wheat genetic background. The TdRCA1 overexpression lines showed colored callus, coleoptile, auricle and stem nodes, as well as up regulation of six anthocyanin-related structural genes. The expression of TdRCA1 was activated by light in a temporal manner. While coleoptile color of 48 and 60 h dark-grown seedlings changed from green to red after 24 h light treatment, those grown in dark for 72 and 96 h failed to develop red coleoptiles after light restoration. Interestingly, the over expression of TdRCA1 resulted in increased resistance to Fusarium crown rot, a chronic and severe fungal disease in many cereal growing regions in the world. Our results offer a better understanding of the molecular basis of coleoptile color in bread wheat.
A hair treatment agent or a hair conditioning composition comprising; from about 0.5 to about 10.0 % by weight of amidoamine, from about 0.1 to about 10.0 % by weight of sulphated and/or sulphonated oil and an aqueous or aqueous-alcoholic carrier. Most preferably, the amidoamine is one of stearamidopropyl dimethylamine, behenamidopropyl dimethylamine and brassicamidopropyl dimethylamine. Preferably, the sulfated or sulfonated oils are derivatives of rapeseed oil or castor oil, such as Turkey red oil. Preferably, the agent comprises an esterquat or quaternary ammonium compound. Preferably, the hair treatment agent is substantially free of alkoxylated emulsifiers, alkyoxylated surfactants and polymeric thickening agents. Preferably, the agent has a pH in the range 1 to 11. Also disclosed is the use of a hair treatment agent (as described herein) for reducing static charges on the hair and for reducing hair breakage. Further disclosed is a method for the production of a treatment agent for human hair, e.g. an oil-in-water emulsion.
The study aimed to compare the effects of a diet rich in fat, carbohydrates and protein on rat kidneys. The study was conducted on 40 Wistar albino rats bred at İnönü University Faculty of Medicine after the approval of the ethics committee. Rats were randomly divided into 4 groups: Control group, and the groups where the animals were fed with high carbohydrate, fat and protein rich feed. After the applications, the rat kidney tissues were removed by laparoscopy under anesthesia and blood samples were collected. 13 weeks long fat-rich and carbohydrate feed application had negative effects on oxidant-antioxidant balance, oxidative stress index, inflammation markers, kidney functions tests, histopathology and immunohistochemistry caspase-3 findings in rat kidney tissues, especially in the carbohydrate group when compared to the controls. Protein-rich feed, there were no significant difference in biochemical and histopathology compared to the control group. Fat and carbohydrate rich feed led to an increase in oxidative stress in rat kidney tissues. Oxidative stress led to nephrotoxicity, which in turn led to chronic kidney tissue damages. A more balanced and protein-rich diet instead of excessive sugar and fatty food intake could be suggested to prevent chronic kidney damage.
Resistance exercise will be training all major muscle groups 2x/week (2 days upper body, 2 days lower body) at 40-50% 1 repetition max (RM; estimated from 10 RM baseline testing) for 3 sets of 10-12 reps. This equals 4x/week for the 3 week intervention period.
A glucose meter with an adjustable alarm and an integral wireless transmitter to send a user a reminder to take a second glucose level measurement. The glucose meter with an alarm features a housing with a display and input buttons connected to a microprocessor. The housing has a slot designed to accept a strip with a sample of blood. A glucose level sensor within the housing is adapted to measure the glucose level of the blood sample. After the measurement is taken, an alarm is set to activate after a predetermined period of the time, reminding a user to take a second glucose level measurement. The alarm can be an auditory or a vibrating alarm. Additionally, the wireless transmitter is designed to send an email or text message to a user as a reminder to take a second glucose level measurement.
This group contains 20 subjects. All subjects in this group will undergoing implantation of Xience V/Prime stent. The Primary Endpoint of this group is 2st month QCA and OCT assessment.