anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Because of these unique qualities, the MHQ has become one of widely used tools by the clinicians to assess quality-of-life relevant to functioning of hands and upper limb. It has also been translated to many other languages from the original English version for an easy understanding and adaptation into the local population. despite being its availability in approximately 20 different languages., the Urdu translation of this questionnaire has not yet been published anywhere. Urdu is Pakistan's official language, and the majority of Pakistanis are unable to understand this subjective assessment questionnaire originally written in English. It is required to translate the questionnaire into Urdu for Pakistanis people as the upper limb disorders are one of the most prevalent musculoskeletal disorders in Pakistan. Urdu translation of Michigan Hand Outcomes Questionnaire will help the Pakistan population with hand disorders to describe their pain or disability experience clearly. The Clinical physiotherapists of Pakistan can be capable of capturing the subjective health states of Pakistani patients with hand disorders more conveniently using the Urdu translated MHQ.
The invention discloses an antibacterial cream prepared from various herbal medicines. The antibacterial cream is prepared from 30 parts of Chinense Golden Larch Bark, 20 parts of parmelia tinctorum Despr., 25 parts of radix angelica sinensis, 20 parts of hypericum attenuatum, 30 parts of water chestnuts, 30 parts of glabrous sarcandra herb, 30 parts of fructus aurantii, 25 parts of lespedeza cuneata (Dum. Cours.)G. Don, 30 parts of radix salvia, 20 parts of pink reineckea herb, 10 parts of plantain herb, 25 parts of radix astragali, 10 parts of cissus pteroclada hayata, 25 parts of radix scutellariae, 30 parts of oroxylum indicum, 25 parts of rhizoma coptidis, 10 parts of mint, 30 parts of reed rhizomes, 25 parts of cinnamon and 20 parts of Chinese prickly ash. The antibacterial cream prepared from various herbal medicines and used for treating eczema has the effects of clearing away heat and removing dampness, clearing away toxic materials and performing dehumidification, performing sterilization and relieving itching, and dispelling the wind and removing eczema, during treatment, the antibacterial cream is used in a coating mode and is used twice or three times a day, and the affected part is coated with the antibacterial cream and slightly rubbed. The antibacterial cream prepared from various herbal medicines has the advantages of being good in curative effect and taking effects fast, diseases are not prone to relapse after being cured, and the antibacterial cream is free of toxic and side effects.
The invention discloses a 2,7-naphthyridine derivative and a preparation method and application thereof. The derivative is a compound with a structure represented by the formula I, or a pharmaceutically acceptable equivalent or salt thereof. The compound represented by the formula has a good inhibiting effect against various kinase activities. Half inhibitory concentrations of the compound against kinases such as c-Met, KDR, c-kit, and the like are generally lower than 10<-7>mol.L<-1>. Also, according to the embodiment of the invention, the compound with the structure of the formula I has an inhibiting effect against the proliferation of various tumor cells. The formula I is represented as the following.
In studies of ACE inhibitors in hypertensive patients with unilateral or bilateral renal artery stenosis, increases in serum creatinine or blood urea nitrogen have been reported. In a 4-day trial of valsartan in 12 hypertensive patients with unilateral renal artery stenosis, no significant increases in serum creatinine or blood urea nitrogen were observed. There has been no long-term use of Diovan in patients with unilateral or bilateral renal artery stenosis, but an effect similar to that seen with ACE inhibitors should be anticipated.

As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals. In patients with severe heart failure whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists has been associated with oliguria and/or progressive azotemia and (rarely) with acute renal failure and/or death. Similar outcomes have been reported with Diovan.

Some patients with heart failure have developed increases in blood urea nitrogen, serum creatinine, and potassium. These effects are usually minor and transient, and they are more likely to occur in patients with pre-existing renal impairment. Dosage reduction and/or discontinuation of the diuretic and/or Diovan may be required. In the Valsartan Heart Failure Trial, in which 93% of patients were on concomitant ACE inhibitors, treatment was discontinued for elevations in creatinine or potassium (total of 1.0% on valsartan vs. 0.2% on placebo). In the Valsartan in Acute Myocardial Infarction Trial (VALIANT), discontinuations due to various types of renal dysfunction occurred in 1.1% of valsartan-treated patients and 0.8% of captopril-treated patients. Evaluation of patients with heart failure or post-myocardial infarction should always include assessment of renal function.
Transient global amnesia (TGA) is characterized by sudden and temporary memory impairment, while transient epileptic amnesia (TEA) represents amnestic attacks as the main manifestation of focal epilepsy with presumed temporal origin. We present a 48-year-old patient who experienced transient amnesia 10 weeks after right selective amygdalo-hippocampectomy for right temporal lobe epilepsy. Despite TEA being a plausible explanation for amnesia in patients with temporal lobe epilepsy, no epileptiform discharges were found during the amnestic episode and key features indicative of TGA, including long duration, isolated occurrence, and dense anterograde amnesia of the episode, argued against a diagnosis of TEA in this case. Notably, the patient has remained seizure-free (now 4,5 years) and stopped taking antiseizure medication 32 months after surgery. Although TGA clinical criteria formally exclude patients with recent active epilepsy, neurologists should be aware that TGA can occur after epilepsy surgery in the temporal lobe. Therefore, we consider it of high clinical relevance to establish a careful differential diagnosis between TGA and epileptic amnestic attacks after epilepsy surgery to avoid unnecessary reintroduction or continuation of antiseizure medication. Additionally, this case presents the first comparison of detailed neuropsychological test results before and after a presumed TGA episode, revealing a complete recovery of anterograde memory functions within 1 day. PLAIN LANGUAGE SUMMARY: A 48-year-old patient experienced an episode of transient amnesia 10 weeks after epilepsy surgery. Given the patient's history, an epileptic origin of the episode initially seemed likely. However, tests revealed no seizure activity during the episode and the characteristics matched a condition called transient global amnesia. This case highlights the importance of correctly diagnosing memory impairments after epilepsy surgery to prevent unnecessary treatment.
BACKGROUND: Women with a history of preeclampsia have evidence of premature atherosclerosis and increased risk of myocardial infarction and stroke compared with women who had a normotensive pregnancy. Whether this is due to common risk factors or a direct impact of prior preeclampsia exposure has never been tested in a mouse atherosclerosis model.
METHODS: Pregnant LDLR-KO (low-density lipoprotein receptor knockout; n=35) female mice were randomized in midgestation to sFlt1 (soluble fms-like tyrosine kinase 1)-expressing adenovirus or identical control adenovirus. Postpartum, mice were fed high-fat diet for 8 weeks to induce atherogenesis. Comparison between the control and preeclampsia models was made for metabolic parameters, atherosclerosis burden and composition by histology, plaque inflammation by flow cytometry, and aortic cytokines and inflammatory markers using a cytokine array.
RESULTS: In pregnant LDLR-KO mice, sFlt1 adenovirus significantly induced serum sFlt1, blood pressure, renal endotheliosis, and decreased pup viability. After 8 weeks of postpartum high fat feeding, body weight, fasting glucose, plasma cholesterol, HDL (high-density lipoprotein), and LDL (low-density lipoprotein) were not significantly different between groups with no change in aortic root plaque size, lipid content, or necrotic core area. Flow cytometry demonstrated significantly increased CD45+ aortic arch leukocytes and CD3+T cells and aortic lysate contained more CCL (CC motif chemokine ligand) 22 and fetuin A and decreased expression of IGFBP6 (insulin-like growth factor-binding protein 6) and CCL21 in preeclampsia-exposed mice compared with controls.
CONCLUSIONS: In atherogenic LDLR-KO mice, exposure to sFlt1-induced preeclampsia during pregnancy increases future atherosclerotic plaque inflammation, supporting the concept that preeclampsia directly exacerbates atherosclerotic inflammation independent of preexisting risk factors. This mechanism may contribute to ischemic vascular disease in women after preeclampsia pregnancy.
PURPOSE: To investigate the impact of acute muscle wasting on 90-day mortality in older patients with severe pneumonia using ultrasound and chest computed tomography (CT).
METHODS: Quadriceps muscle layer thickness was measured via ultrasound on days 1, 7, and 14, and cross-sectional area of the erector spinae muscle was assessed using chest CT on days 1 and 14 in patients aged ≥ 65 years old. The primary outcome was all-cause 90-day mortality. Receiver operating characteristic curves were conducted for muscle loss to predict 90-day mortality. Cox proportional hazard models and Kaplan-Meier survival curves were employed to evaluate the association between muscle loss and 90-day mortality.
RESULTS: Sixty-two patients were enrolled with median age of 80.2 years, 29 (46.8%) were men and 28 (45.2%) patients died. Muscle mass measured using ultrasound and CT decreased significantly from baseline to day 14 in the non-survivor group. Muscle loss assessed by ultrasound (with minimum and maximum pressure) and CT independently predicted all-cause 90-day mortality (adjusted hazard ratios = 1.497, 1.400 and 1.082; P < 0.001, P = 0.002, and P = 0.004; respectively), and cutoff values of muscle loss were 0.34 cm, 0.11 cm and 4.92 cm2, correspondingly. A higher muscle loss had an increased risk of 90-day mortality.
CONCLUSIONS: Acute muscle wasting assessed by ultrasound and chest CT persisted for 14 days and was an independent predictor of adverse outcomes in older patients with severe pneumonia. A greater decline in muscle mass was associated with a higher 90-day mortality risk.
Patients will be instructed to perform an usual care physical therapy intervention protocol. Participants in this group will be told to undergo gentle self-performed joint mobilization and stretching exercises. Each initial contact session will last approximately 1 hour. After baseline, participants will be instructed to undergo at least two sessions per week during 3 consecutive months.
Lifetime prevalence of post-traumatic stress disorder (PTSD) is estimated at 8%. Exposure to traumatic events increases the risk of poor physical health, and chronic PTSD often leads to disability. The pathophysiology of PTSD is continually being explored in order to help find better treatment modalities for this debilitating disorder. Proposed mechanisms for the altered stress axis in PTSD include changes at the level of the pituitary. Though the pituitary stress hormone axis has been explored, no work has been done to evaluate for changes in the pituitary volume in response to these changes in the stress axis in PTSD. We have designed a study which will assess for differences in pituitary volumes. We will compare volumes in patients with PTSD, non-PTSD subjects who have had a history of trauma, and healthy controls. We will test the HPA axis through the dexamethasone/CRH test, a standardized diagnostic test, and correlate the findings with changes in the pituitary volume. Moreover, we will assess for changes in other endocrine axes and proteins.

We propose to further our understanding of PTSD by establishing a direct link between structure and function. By establishing these links in structure and function, novel therapies which can intervene through the endocrine system may prove to be of benefit in treating PTSD
Radical cystectomy with pelvic lymph node dissection and urinary diversion is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC). However, many patients are unwilling or unable to undergo such major surgery associated with high morbidity and a negative impact on quality of life. Chemoradiotherapy is an established treatment option for muscle-invasive bladder cancer. However, it has not been investigated adequately in NMIBC until now. The European Organisation for Research and Treatment of Cancer (EORTC) 2235 study (NCT06310369) is designed as a multicenter, prospective, international, phase 2 trial of moderate hypofractionated radiotherapy combined with a radiosensitizer in BCG-unresponsive NMIBC patients with carcinoma in situ (CIS) who are not eligible for or declined to undergo radical cystectomy. Patients who have received nadofaragene firadenovec or TAR-200 are eligible. The primary endpoint is the 6-mo complete response (CR) rate defined by the absence of CIS proven by a control biopsy of the bladder. The secondary endpoints include overall survival, progression-free survival, durability of CR, grade 3-4 adverse events rate, patients' quality of life, and organ preservation rate. PATIENT SUMMARY: Intravesical instillation of bacillus Calmette-Guérin is the standard treatment of non-muscle-invasive, also coined as superficial, bladder cancer. In case the cancer recurs, even superficially, there is no other proven treatment than a radical cystectomy-the surgical removal of the bladder. Although the surgical technique has improved dramatically over the past few years, it remains contraindicated in patients with severe comorbidities. In addition, because it affects the quality of life, patients may reject this option. This study will assess the efficacy of external beam radiotherapy, a robust alternative to surgery in muscle-invasive bladder cancer. Radiotherapy will be administered 5 d a week for 4 wk. It will be associated with a "radiosensitizer," an intravenous or oral drug, during the radiotherapy treatment. The study will measure the proportion of patients remaining recurrence free at 6 mo and thereafter. It will also evaluate the safety of the treatment and its impact on quality of life.
INTRODUCTION: Lennox Gastaut syndrome (LGS) as an electroclinical diagnosis has been utilized as a clinical entity for more than 70 years. However, with the recognition of other distinct electroclinical epilepsy syndromes, no consistent single etiology, and the variability of criteria used in clinical trials, the clinical utility of such a diagnosis has been questioned. Recently, the International League Against Epilepsy for the first time defined diagnostic criteria for epilepsy syndromes, thereby allowing consistent language and inclusion criteria to be utilized.
AREAS COVERED: Recent diagnostic criteria for syndrome diagnosis are explored as defined by the International League Against Epilepsy, with further literature reviewed to highlight relevant features, and differential diagnosis explored.
EXPERT OPINION: Developmental and Epileptic Encephalopathy (DEE) is an overall term that may be descriptive of many different epilepsies, most of early onset, whether electroclinically or etiologically defined, of which LGS is one. Although we have moved forward in defining an increasing number of etiologically specific syndromes, this to date remains a minority of the DEEs. Although there is progress with precision medicine targeted at specific causes, the term LGS still remains useful as a diagnosis in defining treatment options, as well as overall prognosis.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the lungs; however, there is cumulating data suggesting that the inflammatory reaction associated with COPD is not restricted to the lungs but has systemic effects. Patients with COPD have increased cardiovascular morbidity and mortality. The suspected link between increased cardiovascular mortality and systemic inflammation is endothelial dysfunction, which in turn is caused by impaired activity of NO. Endothelial dysfunction has been demonstrated in patients with COPD. Furthermore there is a close correlation between endothelial dysfunction in coronary and peripheral vessels, which allows assessing flow-mediated dilation (FMD) in the brachial artery via high resolution ultrasound as an early predictor of atherosclerosis. Moreover, systemic inflammatory markers correlate with endothelial dysfunction in patients with stable COPD.

Exacerbations of COPD are episodes of worsening symptoms characterized by increased airway and systemic inflammation. If systemic inflammation is a cause of endothelial dysfunction in COPD, endothelial function would be suspected to be further impaired during exacerbation and recover thereafter. The purpose of this study is to determine a possible association between the clinical entity of exacerbation, markers of systemic inflammation and endothelial dysfunction in patients with COPD.
The study was conducted as a randomized controlled trial, a non-blinded between 30 September 2019 and 29 November 2019. In the first stage of the present study, the Premenstrual Syndrome Scale was used for all participants and the study was continued with the students with premenstrual syndrome symptoms based on the data acquired from the Premenstrual Syndrome Scale. This stage was used only for restricting the sample group, rather than diagnosing or treating the students. In the second stage, the randomization of students included in the sample group was presented according to the CONSORT diagram. The population of the study consisted of 452 female nursing students studying in the faculty of health sciences in a university. The students (n=75) who were absent in the school, took analgesics during the study, and did not agree to participate in the study, were excluded from the study. The students, who had no diagnosis of psychiatric disorder and history of endometriosis, stated that they menstruated regularly (between 22-35 days), did not use complementary and alternative treatments such as analgesics or massage throughout the study, had no diabetes or neuropathic problem causing nerve injury, did not take oral contraceptives, were over 18 years, and agreed to participate in the study, were included in the study.
A system and method for arranging shipment and insurance for items being shipped in containers with memory devices. An intelligent shipping agent may receive a request to ship an item. The intelligent shipping agent may search a database or solicit quotations to obtain shipping and insurance services for an item to be shipped from an origination to a final destination. The intelligent agent may find an entry in the database or may select a vendor based on received quotations. The selection may maximize value of a product or service at the lowest cost. The memory device may store shipping and insurance information related to the item being shipped in a data file. The memory device may include input devices and sensors to gather and store information before, during and after shipment.
PURPOSE:To provide a particular or powdery composition useful in the fields of foods, medicines, etc., stable and reduced in the change of qualities such as the lowering of vitamin B12 content during preservation, by dispersing the vitamin B12 in alpha-starch. CONSTITUTION:Vitamin B12 is contained in alpha-starch in a dispersion state. The dispersing ratio of the vitamin B12 is 0.05-100pts.wt. based on 100pts.wt. of the alpha-starch. The particular or powdery composition can be further coated with wax. In the case, the wax is usually used in an amount of 0.1-10wt.% based on the total amount of the composition. The composition is stable without being substantially affected by other agents, when compounded with the other medical agents to prepare various preparations. The composition has advantages such as good fluidity and excellent compounding properties with other agents.
The invention discloses an application of a Plukenetia volubilis husk extract in preparation of blood pressure lowering medicines. An extraction method for the Plukenetia volubilis husk extract comprises the following steps of crushing Plukenetia volubilis husks, adding a solvent into the crushed Plukenetia volubilis husks, carrying out decocting extraction, filtering out the husks, filtrating an extracting solution, and carrying out concentration, thereby preparing the Plukenetia volubilis husk extract. According to the application, the natural plant extract is adopted, so that toxic or side effects on human bodies caused by Western medicines such as captopril are avoided. The extraction method is easy and feasible and is flexible in manner. Through carrying out an intragastric administration test on rats by using the Plukenetia volubilis husk extract, a research result shows that the Plukenetia volubilis husk extract has a remarkable blood pressure lowering effect, so that the condition that the Plukenetia volubilis husks contain blood pressure lowering functional components is deduced. The Plukenetia volubilis husk extract belongs to plant extracts and is stable and mild in effect, no obvious toxic or side effects is discovered at present, and the abuse of the traditional Western medicines that sequelae of diabetes are aggravated is avoided while the Plukenetia volubilis husk extract plays a role in lowering blood pressure.
FIELD: veterinary science, veterinary diagnostics. SUBSTANCE: method deals with titrating complement and hemolysin, tested serum is inactivated, estimated amount of total brucellosis antigen before preparing working dilution is mixed with antigen from Mycobacterium bovis and Mycobacterium tuberculosis at 1:1 ratio, then mixture is diluted with physiological solution at unified titer of 1:75 and added into reaction at the quantity of 2 ml. Then complement is supplemented and stored at room temperature for 40 minutes followed by incubation upon water bath at 37-38 C for 30 min, then hemosystem is added and reincubated at water bath for 20 min at the same mode. Accounting and evaluation of reaction is conducted after 16-18-h exposure at room temperature. EFFECT: higher efficiency to conduct simultaneous diagnostics of brucellosis and tuberculosis, to increase higher sensitivity in comparison with known methods. 2 tbl