anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pemigatinib is a kinase inhibitor with the chemical name 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one. Pemigatinib has a molecular formula of C24H27F2N5O4 and molecular mass of 487.5 g/mole. Pemigatinib has the following chemical structure:

Pemigatinib is a white to off-white solid that is not hygroscopic. The solubility of pemigatinib is pH dependent with decreasing solubility observed with increasing pH. PEMAZYRE tablets are uncoated and for oral administration. Tablets are available containing 4.5 mg, 9 mg, or 13.5 mg of pemigatinib active ingredient. The inactive ingredients include magnesium stearate, microcrystalline cellulose, and sodium starch glycolate.
INTRODUCTION: Ischaemic heart disease including ST-segment elevation myocardial infarction (STEMI) is the leading cause of death among Malaysians. Total ischaemic time (TIT) which consists of patient delay and systemic delay is a strong predictor of cardiovascular outcome in STEMI. Primary percutaneous coronary intervention (PPCI) is superior to medical thrombolysis in improving STEMI patients' survival outcomes. Our study aims to provide an insight into the clinical and geographical characteristics of STEMI patients, their health-seeking behaviour, TIT, interventions received and short-term cardiac mortality outcomes in the effort to improve the existing coronary care service.
MATERIALS AND METHODS: This is a descriptive study looking into patients who were diagnosed with STEMI and presented to or were referred to Sarawak Heart Centre between 1st July 2022 and 31st December 2022.
RESULTS: A total of 183 patients were recruited and 33.3% were <50 years old. The majority were in a different division during symptom onset from where the local PPCI centre is located and some underwent one or two transits before arrival at the revascularisation centre. More presented outof- hour and they were more likely to present within the PPCI window. The median TIT for the study population was 3.3 hours. The short-term cardiac mortalities were 9.3% and only the Killip class was found to have a significant association. In this study, TIT was not significantly associated with short-term mortalities but those who died had a longer median TIT.
CONCLUSION: A local STEMI network should be set up using the 'Hub-and-Spoke' model in a staged-wise approach to reduce TIT given that PPCI is now the gold standard of treatment alongside continuous effort in patient education.
The present invention relates to magnetic single-core nanoparticles, in particular stable dispersible magnetic single-core nanoparticles (e.g. single-core magnetite nanoparticles) having a diameter between 20 and 200 nm in varied morphology, and the continuous aqueous synthesis thereof, in particular using micromixers. The method is simple, quick and cost-effective to perform and is carried out without organic solvents. The single-core nanoparticles produced by the method form stable dispersions in aqueous media, i.e. not having a tendency to assemble or aggregate. In addition, the method offers the possibility of producing anisotropic, super-paramagnetic, plate-shaped nanoparticles which, due to their shape anisotrophy, are extremely suitable for use in polymer matrices for magnet field-controlled release of active substances.
A synthetic peptide substantially including amino acids 45-55, 90-99 or 60-70 of the HIV-1-protease sequence is claimed. Also claimed is an agent for the treatment of HIV or SIV infections comprising a HIV protease not showing protease activity (PR) for HIV1-reverse transcriptase (RT) but stimulating or inhibiting it. More specifically the active centre of the protease is destroyed by mutation or deletion, or the deriv. is a protease shortened at the C- terminus by 2 amino acids. USE/ADVANTAGE - The agents are used for the treatment of HIV or SIV infections. Compared to known treatment using e.g. nucleotide analogues, the new peptides do not interfere with normal cell function.
Intensive Care Unit Sedation

A total of 729 patients in the clinical studies were 65 years of age and over. A total of 200 patients were 75 years of age and over. In patients greater than 65 years of age, a higher incidence of bradycardia and hypotension was observed following administration of dexmedetomidine HCl [see Warnings and Precautions (5.1, 5.2)]. Therefore a dose reduction may be considered in patients over 65 years of age [see Dosage and Administration (2.3) and Clinical Pharmacology (12.3)].

Procedural Sedation

A total of 131 patients in the procedural sedation clinical studies were 65 years of age and over. A total of 47 patients were 75 years of age and over. Hypotension occurred in a higher incidence in dexmedetomidine HCl-treated patients 65 years or older (72%) and 75 years or older (74%) as compared to patients less than 65 years (47%). In patients greater than 65 years of age, reduce the loading infusion dosage for initiation of procedural sedation and consider reducing the maintenance infusion dosage for maintenance of procedural sedation [see Dosage and Administration (2.3) and Clinical Pharmacology (12.3)].
The sleep education therapy will be administered in self-guided digital format over 4 weeks with addition of telehealth video-consultations with a research nurse one time per week. The SET will focus on sleep physiology, different sleep disturbances and sleep hygiene measures. A booster session will be provided 1-2 weeks postoperative.
Fractured neck of femur is a common cause of admission to hospital in elderly patients and requires operative fixation. The recommended anaesthetic technique for these cases is spinal anaesthesia, which is performed with the patient in lateral decubitus. Positioning the patient prior to administering spinal anaesthesia is the most painful manouvre due to the movement of the fractured bone.

Regional anaesthesia is effective in alleviating pain due to trauma, and it has the advantage of producing localized but complete pain relief (1). Femoral nerve blockade prior to positioning for spinal anaesthesia provides excellent pain relief and is a well tolerated procedure (2-5).

Using ultrasound guided femoral nerve block is a relative new method to improving the block success rate. It is widely used in our hospital. In a recent study Casati and al. showed a 42 % decrease of ED50% using ultrasound for localization of the femoral nerve (6). In a recent editorial by Brian D. Sites was mentioned that the positioning of the local anaesthetic in ultrasound guided blocks is unclear (7). We currently follow different patterns in relation to injection of the local anaesthetic solution around the femoral nerve. One of them is a circumferencial spread around the nerve. This, however, needs several needle passes which are likely to be painful for the patient. Another option is injecting the local anaesthetic on one side, above or below the nerve without changing the position of the tip of the needle, avoiding patient discomfort. Whether this results in a comparable quality of sensory block is unknown. The femoral nerve is separated in branches at this level and we assume that the spread of local anaesthetic may influence the quality and the distribution of the block. We propose to study the characteristics of femoral nerve block in relation to different patterns of local anaesthetic injection (circumferencial, inferior or superior).
The invention discloses a compound docetaxel ester microsphere injection and a preparation method thereof, belonging to the technical field of medicines. The compound docetaxel ester microsphere injection is characterized by being prepared from the following raw materials in weight parts: 0.5 to 5 parts of docetaxel, 30-150 parts of Brucea javanica oil, 30-150 parts of middle-chain triglyceride, 10-30 parts of lecithin, 10-60 parts of polyethylene glycol surface active agents, 20-35 parts of glycerine and 700-950 parts of sterilized water for injection. The compound docetaxel ester microsphere injection of the invention is oil in water type microsphere preparation. The docetaxel as a main drug is coated in the Brucea javanica and middle-chain triglyceride compound oil phase of the oil in water type microsphere. The microsphere has a smaller grain diameter (which is lower than 100nm), and the preparation has better stability. The compound oil phase compositions play a cooperative anticancer role, and reduce the stimulation reaction of the injection and the side reactions such as hemolysis, allergy and the like. The invention has targeting function and increases the medicine effect.
BACKGROUND: This study aimed to present a case of bilateral symmetric onset of acute idiopathic maculopathy after high fever with peripheral vascular occlusion.
CASE PRESENTATION: A 54-year-old yellow female experienced acute binocular visual acuity decrease after 1 day of high fever, and binocular visual acuity decreased to index or anterior. OCT in the external hospital showed dome-shaped cortical detachment in the symmetrical macular area of both eyes with subretinal fluid, discontinuity in the ellipsoid zone and the chimera. The patient autonomously administered antibiotics and non-steroidal anti-inflammatory agents, including amoxicillin and ibuprofen. Following a three-day period, the patient's visual acuity demonstrated significant improvement. Additionally, macular edema demonstrated a notable reduction as indicated by optical coherence tomography, while the presence of peripheral retinal vascular occlusions was also observed on fluorescein fundus angiography. At the onset of 6 days, oral hormone therapy was given in the outside hospital, with no significant improvement in visual acuity.23 days after the onset of the disease, the patient was admitted to our hospital, and was finally diagnosed as acute idiopathic maculopathy combined with the imaging findings of FFA, ICGA and OCT. During the follow-up, the visual acuity of both eyes improved spontaneously.
CONCLUSIONS: This case is a rare acute idiopathic macular lesion with bilateral involvement, accompanied by highly symmetrical peripheral retinal vascular occlusion in both eyes, which deepens our understanding of acute idiopathic maculopathy with a view to providing guidance for subsequent clinical practice.
To investigate the effect of a 70 minute pain neuroscience education session on physiotherapy students' knowledge of pain and their beliefs and attitudes about the treatment of patients with chronic pain. This study was a single-center, cross-sectional study on the pain knowledge of students in a four-year physiotherapy program and their beliefs and attitudes about patients with back pain.Students were eligible to participate if they were enrolled at physiotherapy undergraduate program at Kütahya Health Sciences University Faculty of Health Sciences. Individuals were excluded if they had previously received in depth-teaching on pain neuroscience. The study was completed with 156 students from different classes (first, second, and third year of the program) who agreed to participate in the study. All participants were informed about the study and signed informed consent forms. Pain neurophysiology questionnaire and Pain Attitudes and Beliefs Scale for Physiotherapists were used to assess pain knowladge and attitudes and beliefs. After recording their demographic information, the participants completed the Neuroscience of Pain Questionnaire (NPQ) and Pain Attitudes and Beliefs Scale for Physiotherapists (PABS-PT) at three time points: pre-PNE, immediately post-PNE, and 6 months after PNE.
Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD inhibitor carbenoxolone (18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively employed in the clinic for the treatment of gastritis and peptic ulcer. Carbenoxolone is active on both 11β-HSD1 and 2 isoforms. Here, carbenoxolone is surprisingly shown to reduce both baseline and excessive drinking in rats and mice. The carbenoxolone diastereomer 18α-glycyrrhetinic acid 3β-O-hemisuccinate (αCBX), which the applicants discovered to be selective for 11β-HSD2, was also effective in reducing alcohol drinking in mice. Thus, 11β-HSD inhibitors are a new class of candidate alcohol abuse medications and existing 11β-HSD inhibitor drugs may be re-purposed for alcohol abuse treatment.
The invention relates to the field of traditional Chinese medicine formulae and particularly relates to a traditional Chinese medicine for treating gastritis. The traditional Chinese medicine for treating gastritis is prepared from the following raw medicinal materials in percentage by weight: 5-8% of lemongrass, 5-8% of caulis bambusae in taeniam, 7-10% of chinese mosla herb, 4-6% of caulis perllae, 12-16% of salvia chinensis, 4-6% of serpentgrass, 6-9% of rust-coloured crotalaria herb with roots, 2-5% of scarlet swertia herb, 2-4% of longan seeds, 1-3% of tribulus terrestris, 2-5% of rhododendron micranthum, 4-7% of flos buddlejae, 4-6% of kadsura longepedunculata, 4-6% of ramulus clematis montanae, 5-8% of peucedanum morisonii bess, 1-3% of fructus aurantii, 4-7% of dandelion and 5-8% of citron. The 18 raw medicine materials are mixed and soaked with water and are decocted, and slag is removed to obtain a filtrate. The traditional Chinese medicine for treating gastritis, provided by the invention, has the functions of soothing the liver and regulating qi, clearing away heat and toxic materials, harmonizing the stomach and relieving pain and helping digestion and relieving retention, and has a remarkable curative effect on symptoms such as stomachache, gastrectasia, hyperchlorhydria and the like induced by gastritis. Medicinal materials selected by the traditional Chinese medicine preparation provided by the invention are available, good in compatibility and stability, free from any toxic and side effects, low in cost and remarkable in curative effect. Gastritis does not relapse after being cured, and the traditional Chinese medicine for treating gastritis is worthy of being widely popularized and applied clinically.
The Immediate Start group will participate in the 12-week Moving Together program after completing the baseline assessment. Moving Together is a gentle, live-streaming, group movement program designed specifically for people with memory loss (PWML) and caregivers (CG) to do together. It is based on the in-person Preventing Loss of Independence through Exercise (PLIÉ) and Paired PLIÉ programs. The program combines physical movements to help maintain daily function with mindful body awareness exercises and social interactions to provide a comprehensive, multi-domain program.
Te anonymization index calculation system (100) according to an embodiment calculates an anonymization index including the degree of anonymization and the degree of data addition. The anonymization index calculation system comprises a data storage means (110), an anonymization means (120), an anonymization degree calculation means (130), and an addition degree calculation means (131). The data storage means stores source data including a value for each item for each individual. The anonymization means generates anonymization data from the source data by anonymizing values for some items in the source data. The anonymization degree calculation means calculates the anonymization degree indicating the degree of anonymization, on the basis of the anonymization data and the source data. The addition degree calculation means calculates the degree of data addition, corresponding to the probability of anonymization data being generated from the source data.
Twelve health professionals randomised assign to as equally count. The participants match between the images with scale scores. After 2 weeks, the participants match again.
PURPOSE: Environmental factors modulate oral-health-related quality of life (OHRQoL). The aim of this study was to analyse sociodemographic and behavioural factors affecting the OHRQoL in Spanish adolescents, by using the Child-OIDP (Child-Oral Impacts on Daily Performances) index.
MATERIALS AND METHODS: A cross-sectional study was conducted in 337 adolescent schoolchildren aged 13-15 years. A questionnaire on sociodemographic, behavioural and oral self-perception factors was administered with the Child-OIDP questionnaire. Descriptive statistics, Kruskal-Wallis and Mann-Whitney U-tests, as well as a regression model were used in the data analysis.
RESULTS: The overall mean Child-OIDP index was 3.28±6.55. It was statistically significantly higher in females than in males (p < 0.001). Mothers having a managerial job showed statistical association with worse OHRQoL (p < 0.001). Caries experience and history of dental trauma were not associated with the oral-health-related quality of life (p > 0.05). Halitosis statistically significantly affected the activities of daily living (p < 0.001). Perceived dental problems, dental treatment needs, self-assessment of oral health status and satisfaction with oral health were associated with the impact index (p < 0.05).
CONCLUSION: Mothers who were managers, female sex, presence of halitosis, and perceived dental treatment needs were the most important predictors of the impact index, while dietary habits, oral hygiene, and dental visits did not affect it. Knowledge of these factors will help dental professionals to apply adequate preventive and therapeutic measures.
Oily hormone extracts to be added to oils, creams, emulsions and cosmetics generally are obtd. from teh fatty tissues of insects in general and esp. from the chrysalises of leipdoptera, in a series of steps:- (a) the matter to be treated is dried; (b) it is powdered; (c) it is mixed iwth a material capable of providing a porous support; (d) the oil is extd. under pressure; (e) the oil obtd. is macerated with other fatty liquids; (f) the product is enriched in the active substances stimulating growth and biological activity, which are described collectively as 'the youth factor', by repeating phase (c) and (g) the product is decoloured and deodourised.Dermatological tests have proved the beneficial effects of these oils, and the oil extd. by this method is mcuh clearer than that obtd. by the use of solvents, so that it is better suited for use in cosmetics.
The C. elegans unc-63 gene is a levamisole resistance locus on chromosome I, which encodes a nicotinic acetylcholine receptor (nAChR) α subunit. The derived amino acid sequence of UNC-63 most closely resembles that of UNC-38. Using a gfp: unc-63 fusion construct, expression has been detected in muscles (body wall, vulval) and motorneurons of C. elegans. Nuclear injection into Xenopus laevis oocytes of unc-63 cDNA together with lev-1 and unc-29 results in the expression of a robust functional C. elegans heteromeric nAChR. The EC50 for ACh of the expressed receptor (20νM) resembles that of native nematode muscle nAChRs. Nicotine and anthelmintic drug levamisole are agonists and mecamylamine is an antagonist of this expressed receptor. When unc-38 cDNA is co-injected with cDNAs encoding unc-63, lev-1 and unc-29 much smaller amplitude agonist-activated currents are observed.
Eggs are declared as one of the most important staple diet foodstuffs for human consumption. Compared to other nourishments they contain high level of cholesterol which causes cardiovascular health problems. Thus the need for debasing of cholesterol level in eggs is essential and the endeavours in the poultry breeding, both scientific and practical ones, achieved by genetic cross breeding of hens gave significant improvements and brought about the quality of standards of today in the eggs of average weight from 55 to 57 grams are 1150 mg per per 100 of yolk (200 mg per an egg). There is another way as well. Pour 3 l of silver colloid water in the device with the water filter and scatter the whole amount all over the farm facility for 30 minutes per day in one week. Adjustment of air circulation through the farm facility enables hens to breathe that air enriched with silver particles which cause debasing of cholesterol level in eggs for over 60% up to present standards (465,33 mg per 100 of yolk or 84,63 mg per egg).
A bacteriophage which has an extremely high specificity for specific pathogenic bacteria and, therefore, can surely exterminate the bacteria serving as the host by the phagocytic action thereof. Novel biobactericidal materials prepared with the use of the action of this phage are usable in sterilizing anything to be protected against the infection with pathogenic bacteria, for example, foodstuffs such as fresh foods and kitchens in restaurants and schools so as to exterminate the corresponding bacteria. These biobactericidal materials may contain a mixture of two or more bacteriophages differing in properties. Such materials are highly useful, since two or more pathogenic bacteria can be exterminated thereby at the same time. Not human being, etc. but the pathogenic bacteria serving as the host are exclusively infected with the above-mentioned phage, which makes the phage highly safe. Moreover, it has an extremely potent efficacy. The bacteriophage having a high specificity exclusively for specific pathogenic bacteria and thus being an extremely safe biobactericidal material usable in anything to be protected against the infection with pathogenic bacteria, for example, foodstuffs such as fresh foods and kitchens in restaurants and schools; a method for easily screening the phage; a process for producing the phage; a stabilizer for stabilizing the phage or a preservative therefor; and a reagent and a reagent kit for conveniently detecting the pathogenic bacteria within a short period of time by using the phage.
The invention discloses a bulk drug for treating orthopaedic diseases. The bulk drug is Chinese teasel root saponin VI and is prepared by extracting traditional Chinese medicinal materials which contain the Chinese teasel root saponin VI; the weight percentage content of the Chinese teasel root saponin VI occupies 95.0 to 99.9 percent of the total amount of an extract of the Chinese teasel root saponin VI; and the chemical name of the bulk drug is 3-O-alpha-L-arabopyranose ivy sapogenin-28-O-beta-D-glucopyranose(1-6)-beta-D-glucopyranoside. The invention also discloses a method for preparing the bulk drug - the Chinese teasel root saponin VI. The method comprises the following steps of extraction, concentration, separation of the total saponin, decolorization and purification and refinement. The preparation method has the advantages that the preparation method has high extraction rate and low cost, is safe and environment-friendly and is suitable for industrialized mass production. The invention also provides application of the bulk drug in preparing medicines for preventing and treating the orthopaedic diseases including osteoporosis, fracture and osteoarthritis.
Intervention participants continue to receive routine dialysis care, as well as a 16 week dietary counseling intervention based on Social Cognitive Theory. Dietary counseling is paired with Personal Digital Assistant-based dietary self-monitoring.
FIELD: enzymology. SUBSTANCE: streptolyase solution - preparation containing enzyme streptokinase is isolated from hemolytic streptococcus C culture. Streptolyase is dissolved in 2-6% glucose aqueous solution and polymeric polysaccharide - hyaluronic acid is added at amount 1-2 mg per 100000 U streptolyase and ascorbic acid is added to solution at amount 20-30 mg per 100 ml solution. Enzyme streptokinase is used in medicine for thrombus lysis. EFFECT: improved method of stabilization. 1 tbl