anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a traditional medicine oral liquid for antisenescence, which comprises the following parts: polygonum multiflorum thumb, root of American ginseng, achyranthes, matrimony vine, ichih fruit, raspberry, the special water with 2. 1mg/L strontium and 0. 0006mg/L selenium, the right amount saccharose and antiseptic. The preparing method comprises the following steps: preparing a portion polygonum multiflorum thumb, half of root of American ginseng, root of American ginseng, achyranthes, matrimony vine, ichih fruit, raspberry, 30-40 portion special water with  2. 1mg/L strontium, 0. 0006mg/L selenium and microelement for the next step; (2) immersing polygonum multiflorum thumb with white spirit for 24 hours in order to remove toxin and dry; (3) boiling immersed and dried polygonum multiflorum thumb and the other component with the special water in the container; stopping until the special water is concentrated to 1/10; filtering; cooling; adding the right amount saccharose and antiseptic; pocketing separately. The invention can tonify liver, tonify kidney and soften blood vessel, which treats and prevents senile dementia and hypomnesia, protects and restores neuron, and also treats frequent micturition and emergent micturition.
Recent scientific studies have suggested that people with hand osteoarthritis not only feel pain in their hand joints, they also appear to have increased signals in their brain pain processing pathways. At St George's, University of London, the investigators have been conducting studies to find out which brain regions are activated in subjects with hand osteoarthritis. The investigators have found that certain brain regions (thalamus, insula, cingulate and somatosensory cortex) are activated during painful tasks in patients with hand osteoarthritis but not in healthy people. In this study the investigators will establish whether drugs that inhibit pain processing pathways in the brain can help. Patients who are still having pain despite their usual painkillers will be randomly divided into 3 groups: one group will receive a placebo, the other 2 groups will receive one of two different drugs, duloxetine or pregabalin. Participants will be assessed using questionnaires and a brain scan (functional MRI) before and after 13 weeks of taking the tablets. This study will help us to understand the ways in which people feel pain in osteoarthritis. If our trial proves successful,drugs that dampen central pain pathways could be used in combination with local pain-relieving drugs to improve treatment and reduce disability in patients with hand osteoarthritis.
<P>PROBLEM TO BE SOLVED: To provide a more sensitive and specific antibody for diagnosing various types of cancers in an early stage and to provide a new method for diagnosis.  <P>SOLUTION: Selected cancers including gynecologic cancers such as ovarian cancer, breast cancer, endometrial cancer and/or uterine cancer and lung cancer without limitation are detected, diagnosed, monitored, staged, prognosticated, in vivo imaged and treated through detection of CSGs (cancer specific genes). Nine CSGs are identified and referred to especially native proteins expressed by a gene containing a specific polynucleotide sequence. Other CSG fragments can be detected. An antibody against the CGSs usable for detecting or imaging localization of the CSGs in a patient or fragments of the antibody are provided. The antibody can be a polyclonal or a monoclonal antibody or can be produced by a technique of molecular biology.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This group gets access to the web-based program for stress-management. They will, by their own, go through the automated program. Measurements are conducted before, after as well as 3 months after the intervention.
(see BOXED WARNING , CONTRAINDICATIONS, and WARNINGS). Liver disease impairs the capacity to eliminate valproate. In one study, the clearance of free valproate was decreased by 50% in seven patients with cirrhosis and by 16% in four patients with acute hepatitis, compared with six healthy subjects. In that study, the half-life of valproate was increased from 12 to 18 hours. Liver disease is also associated with decreased albumin concentrations and larger unbound fractions (2 to 2.6 fold increase) of valproate. Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal.
The investigators designed a retrospective clinical trial conducted from January 2015 to December 2020 at the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School. Infertility was defined as the failure of a clinical pregnancy after 12 months or more of regular unprotected intercourse with the same marriage partner. Patients experiencing infertility no younger than the age of 20 who attended the Reproductive Medicine Center of the Affiliated Drum Tower Hospital of Nanjing University Medical School for the first time and had experienced no less than one embryo transplantation between January 2015 and December 2019 were recruited. Patients who had experienced or canceled embryo transplantation cycles for any reason were excluded from this study. The gap year from December 2019 to December 2020 allowed researchers to follow up on the outcomes of pregnancies before 2020. Frozen cycles were performed when high-quality embryos existed to avoid unnecessary ovarian stimulation and oocyte retrieval processes. Investigators were blinded to the outcome of embryo transplantation, and information on pregnancy was gathered through telephone follow-up one year after transplantation.
NEW MATERIAL:A compound expressed by formula I [R1 and R3 are H, (substituted) hydrocarbon residue, heterocyclic group or acyl provided that when R1 and R2 are not H, R1 and R2 may form a cyclic amino together with adjacent N; R4 to R6 are H, lower alkyl or lower alkoxy; m is 2-4] or salt thereof. EXAMPLE:1-Ethyl-5-(4-methyl)pentylindoline-dihydrochloride. USE:A medicine. An active ingredient of central antioxidant, brain cell degeneration-suppressing agent and brain cell necrosis suppressing agent. The aimed compound has action suppressing a cell necrosis owing to glutamic acid and is used in prevention and treatment for cerebral ischemia, anoxia, etc., produced from cerebral infarction, temporary stop of heart stroke, etc., lung operation or cerebral injury, etc. PREPARATION:For example, a compound expressed by formula II is reacted with a compound expressed by formula III (R3, is R3 excluding H; Y is halogen) and the resultant compound expressed by formula V is subjected to catalytic reduction to provide the compound expressed by formula I wherein R2 is H; R2 is R5; R3 is R3.
BACKGROUND: Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogenic drivers, the molecular programs contributing to prostate cancer progression are not fully understood.
METHODS: We analyzed JUN expression in clinical prostate cancer samples across different stages and investigated its functional role in a Pten-deficient mouse model. We performed histopathological examinations, transcriptomic analyses and explored the senescence-associated secretory phenotype in the tumor microenvironment.
RESULTS: Elevated JUN levels characterized early-stage prostate cancer and predicted improved survival in human and murine samples. Immune-phenotyping of Pten-deficient prostates revealed high accumulation of tumor-infiltrating leukocytes, particularly innate immune cells, neutrophils and macrophages as well as high levels of STAT3 activation and IL-1β production. Jun depletion in a Pten-deficient background prevented immune cell attraction which was accompanied by significant reduction of active STAT3 and IL-1β and accelerated prostate tumor growth. Comparative transcriptome profiling of prostate epithelial cells revealed a senescence-associated gene signature, upregulation of pro-inflammatory processes involved in immune cell attraction and of chemokines such as IL-1β, TNF-α, CCL3 and CCL8 in Pten-deficient prostates. Strikingly, JUN depletion reversed both the senescence-associated secretory phenotype and senescence-associated immune cell infiltration but had no impact on cell cycle arrest. As a result, JUN depletion in Pten-deficient prostates interfered with the senescence-associated immune clearance and accelerated tumor growth.
CONCLUSIONS: Our results suggest that JUN acts as tumor-suppressor and decelerates the progression of prostate cancer by transcriptional regulation of senescence- and inflammation-associated genes. This study opens avenues for novel treatment strategies that could impede disease progression and improve patient outcomes.
Patients undergo image-guided hypofractionated RT over 35 minutes 5 days a week for 2 weeks followed by 5 fractions of hypofractionated RT boost. Patients also receive standard carboplatin and paclitaxel for 3 weeks.
PURPOSE: The purpose of this study was to evaluate the potential contribution of limited English proficiency on daily hearing aid wear time for children with hearing loss.
METHOD: A retrospective chart review was completed to evaluate hearing aid wear time based on data logging information available at the time of a follow-up visit following an initial hearing aid fitting. Children were included in the study if they had permanent bilateral hearing loss and were less than 60 months of age at the time of their first follow-up visit. Wear time was compared between children who attended an interpreter-mediated appointment and those who did not have an interpreter present. The presence of an interpreter at the appointment was the study indicator that the family had limited English proficiency.
RESULTS: Children from families with limited English proficiency exhibited significantly shorter daily wear time (M = 1.3 hr) than their peers whose families were English-proficient speakers, thus, having a shared language with their audiologists (M = 5.2 hr).
CONCLUSIONS: Results of this study suggest that family-clinician language discordance might put children at greater risk of shorter hearing aid wear time than children whose caregivers share a common language with their child's audiologist. There can be many linguistic, cultural, and educational factors that contribute to hearing aid wear time in children whose families have limited English proficiency as well as different approaches to improving that wear time. Efforts should ensure that hearing and hearing aid-related information is accessible to all families, especially those with clinician-family language discordance. Such efforts can include, among others, training that improves clinicians' cultural and linguistic responsiveness to the diverse families they serve.
PURPOSE:To obtain an anticancer agent containing a purified lanolin fatty acid whose raw material is a wool fat as an active ingredient and having strong anticancer action and extremely low side effect. CONSTITUTION:The aimed agent contains as an active ingredient lanolin fatty acid which is a fatty acid obtained by using a wool lipid as a raw material and purifying the lipid. For example, a purified lanolin fatty acid is obtained by deodorizing a lanolin fatty acid produced by saponifying a wool fat with an alkali according to a conventional method by usual decoloring and steam distillation method. The resultant purified lanolin fatty acid may be directly used for the agent, or a fractionated product obtained by fractionating above- mentioned lanolin fatty acid according to the difference of melting point, e.g., into a low melting point part (<50 deg.C), intermediate melting point (50-70 deg.C) part and high melting point (>70 deg.C) part may be also used. The fatty acid obtained from the low melting point part provided strong anticancer action. Further, a lanolin fatty acid obtained by fractionating above-mentioned lanolin fatty acid e.g., using a silica gel column and solvents having different polarity such as hexane, chloroform, etc., may also be used.
Major depressive disorder is a serious form of depression that may be treated with psychotherapy. However, up to 40% of adults with depression do not show reduced symptoms when treated with cognitive therapy or behavioral activation (BA), two common forms of psychotherapy. Certain indicators are generally linked with a successful outcome of psychotherapy-demographic and clinical characteristics, comorbidity, and treatment adherence-but no factors reliably predict outcomes of psychotherapy in individuals. This study will test whether two characteristics related to the way people process emotions, affective asymmetry and affective reactivity, can predict whether people with depression will improve with BA therapy.

Both depressed and healthy participants will be recruited for this study. Participation in this study will last 31 weeks. All participants will complete baseline assessments at Weeks 1 and 2. Depressed participants will then begin receiving 16 weekly sessions of BA therapy. All participants will be assessed again after 8, 16, 17, and 28 weeks. Assessments will include the following: a urine toxicology screening; interviews on mental and physical health, family and childhood experiences, and current mood and functioning; computer tasks; recordings of electroencephalography (EEG) activity; recordings of reaction to a startle probe; recordings of electromyography (EMG) activity; recordings of electrodermal activity (EDA); and measurement of blood pressure.
PURPOSE:A hair cosmetic providing hair with combing properties and softness as well, having controlling effect on static electricity and a little stimulation, containing an ester salt and higher alcohol obtained from an amino acid and an a higher alcohol. CONSTITUTION:A hair cosmetic containing (A) an amino acid alkyl ester ester salt obtained by condensing an amio acid with a higher alcohol, followed by neutralization and (B) a higher alcohol in a weight ratio of (A/B) of (3/1)-(1/9) [preferably (1/1)-(1/5)]. The total amount of the components (A+B) is 0.1- 20.0wt% (preferably 0.1-10.0wt%). The amount of the component A and that of the component B are 0.1-10wt% and 0.1-5.0wt% based on the whole cosmetic amount respectively. Glycine cetyl ester hydrochloride, etc. may be cited as the component A, it is structurally cationic, so it has strong affinity for hair, and it provides hair with various kinds of effects.
Systems and methods for phenotyping clinical data are provided. The method includes obtaining episodic records comprising unstructured clinical data from an electronic medical record (EMR) or electronic health record (EHR) for patients. The method also includes filtering the episodic records by language pattern recognition to identify episodic records that each includes an expression related to a clinical condition. The method also includes splitting each episodic record to obtain snippets comprising tokens. The method also includes predicting if an episodic record represents an instance of the clinical condition using a trained classifier. The trained classifier includes an aggregation function that aggregates the snippets to output a corresponding representation for the episodic record, and an interpretation function that interprets the corresponding representation to output a corresponding prediction for whether the episodic record represents an instance of the clinical condition.
The invention discloses kind cecropin antimicrobial peptides and an application thereof, belong to technical field of molecular biology. Class cecropin antimicrobial peptides is made up of 31 amino acid, and its molecular weight is 3833.7Da. This antibacterial peptide can suppress the growth of the bacteriums such as staphylococcus aureus, fowl pasteurella multocida, Salmonella gallinarum and chicken colibacillosis, compared with the common antibiotics such as penicillin, streptomysin, brizolina, azithromycin, fungistatic effect is relatively better, with Cecropin? B, Cecropin? A, Cecropin? the cecropin antimicrobial peptides of the routines such as P1 is compared, and has stronger bacteriostatic activity. This antibacterial peptide is 625 μ g/mL to the minimal inhibitory concentration of Salmonella gallinarum, has good heat endurance simultaneously, in the research and development of antibiotic property medicine, has a good application prospect.
The traditional hospital-based co-ed CR programs include on-site group exercise training sessions 1-2 days/week. Participants are encouraged to walk at home on alternate days of the week. Education sessions are also given in a group format.
BACKGROUND: High-intensity therapy is recommended in current treatment guidelines for chronic poststroke aphasia. Yet, little is known about fatigue levels induced by treatment, which could interfere with rehabilitation outcomes. We analyzed fatigue experienced by people with chronic aphasia (>6 months) during high-dose interventions at 2 intensities.
METHODS: A retrospective observational analysis was conducted on self-rated fatigue levels of people with chronic aphasia (N=173) collected during a previously published large randomized controlled trial of 2 treatments: constraint-induced aphasia therapy plus and multi-modality aphasia therapy. Interventions were administered at a higher intensity (30 hours over 2 weeks) or lower intensity (30 hours over 5 weeks). Participants rated their fatigue on an 11-point scale before and after each day of therapy. Data were analyzed using Bayesian ordinal multilevel models. Specifically, we considered changes in self-rated participant fatigue across a therapy day and over the intervention period.
RESULTS: Data from 144 participants was analyzed. Participants were English speakers from Australia or New Zealand (mean age, 62 [range, 18-88] years) with 102 men and 42 women. Most had mild (n=115) or moderate (n=52) poststroke aphasia. Median ratings of the level of fatigue by people with aphasia were low (1 on a 0-10-point scale) at the beginning of the day. Ratings increased slightly (+1.0) each day after intervention, with marginally lower increases in the lower intensity schedule. There was no evidence of accumulating fatigue over the 2- or 5-week interventions.
CONCLUSIONS: Findings suggest that intensive intervention was not associated with large increases in fatigue for people with chronic aphasia enrolled in the COMPARE trial (Constraint-Induced or Multimodality Personalised Aphasia Rehabilitation). Fatigue did not change across the course of the intervention. This study provides evidence that intensive treatment was minimally fatiguing for stroke survivors with chronic aphasia, suggesting that fatigue is not a barrier to high-intensity treatment.
Slow transit constipation (STC) is a long-lasting and prevalent intestinal condition, marked by hard, dry feces. The primary cause of STC may be attributed to an imbalance in the gut's microbial community and alterations in its metabolic byproducts. Tongbian formula (TB), a traditional Chinese medicinal formula, has been used to treat STC and shows a great effect on relieving constipation. The role of TB in regulating intestinal microbiota has not been fully elucidated. Herein, we investigated the potential effect of TB on gut microbiota and further explored the potential mechanism behind its effects. Our study demonstrated that TB significantly increased fecal water content and intestinal ink propulsion rate in loperamide (Lope)-induced STC rats. 5-HT signaling was suppressed in STC colon tissue, and the abundance of butyric acid (BA) in colonic contents was significantly down-regulated after Lope treatment. Notably, TB administration led to the restoration of microbial dysbiosis and the up-regulation of BA content, subsequently activating 5-HT signaling pathways. When BA was combined with a tryptophan hydroxylase-1 (TPH1) inhibitor, which is crucial for 5-HT synthesis, its therapeutic efficacy for treating STC was compromised. TB alleviates STC by reversing the intestinal microbiota imbalance and activating the 5-HT signaling in the colon through increasing BA levels. These findings suggest that TB is an ideal candidate for STC treatment.
The test group - 10 minutes before upper GI endoscopy, patients will drink a solution of 50ml water + 2 capsules of KREON 25000 UI, opened (with minimicrospheres, pellets) + 1.2g sodium bicarbonate, mixed. Adding sodium bicarbonate is necessary to dissolve the minimicrospheres of KREON.
The present disclosure relates to an artificial saliva gel and uses thereof to treat or ameliorate dry mouth (xerostomia). The gel can be of a high viscosity that is maintained at body temperature or when exposed to bodily fluids (for instance, saliva). In some embodiments, the gel can act as a lubricant. Although water-based, the gel can be hydrophobic and not readily dissolvable in bodily fluids. In some embodiments, the gel can be sterile, safe for long-term repeated ingestion, and include a preservative. In some embodiments, the gel can comprise a dental agent for inhibiting growth of dental microorganisms. In order to achieve sterility while maintaining a desired viscosity range, the gel can include a viscosity stabilising agent such as a viscosity protection agent for protection from radiation induced breakdown. The gel can also include a coloring and/or a flavoring agent.
The invention relates to a preparation method of a traditional Chinese medicine for treating lung-yin-loss-type hyperlipemia, belonging to the technical field of preparation methods of traditional Chinese medicines. The existing method for treating lung-yin-loss-type hyperlipemia generally adopts lipid regulators, and has the defect of great toxic and side effects. The technical scheme is as follows: the preparation method comprises the following steps: taking mahonia leaf, Galium aparine, Dysosma versipellis, calamitas urinae hominis, berberis root, isatis leaf, garden euphorbia herb, Herba Lysimachiae, Aster ageratoides, radix sophorae subporstratae, sugar cane, lichen, gypsum, gentian, Freshwater snail, ampelopsis root, figwort, Barbat Skullcap, lobelia chinensis, Corydalis bungeana, picrorhiza rhizome, licorice and the like; and soaking the traditional Chinese medicines in water, decocting with soft fire, and filtering to remove slag to obtain liquor, thereby obtaining the traditional Chinese medicine for treating lung-yin-loss-type hyperlipemia. The prepared traditional Chinese medicine liquid has the advantages of small toxic and side effects, short treatment course and high cure rate. The monarch, minister, assistant and guide medicines are combined perfectly. While using the Chinese drugs, the traditional Chinese medicine avoids untoward reactions, anaphylactic reactions and toxic reactions caused by western medicine antibiotics.