anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study tests the hypothesis that an oral CCK antagonist GSKI181771X will reduce the size of a binge meal. It was intended to study the effects of increasing doses on antagonist on normal individuals to find an effective dose in a non-binge meal before moving to a binge meal. Once the effects of the antagonist on a binge meal were found, the compound would be used on patients with bulimia nervosa. However, the product expired and more was not available before the patients were tested. Data are presented for the normal participants who were instructed to eat normally, followed by a group that was instructed to binge eat. Comparisons were made between groups with different instructions and between binge and normal meals.
The adjuvant chemotherapy was started 4-6 weeks after D2 radical operation. The SOX regimen was repeated every 3 weeks for 8 cycles.
This study is a randomized placebo control trial. The designation of aromatherapy versus placebo will be randomized, but no procedures will be performed for study purposes that would not be normally performed for a patient's clinical assessment.

Women scheduled for Office Hysteroscopy at the Women's Health Medical Plaza Clinic (UF Shands) clinic will be invited to participate. Participants who meet inclusion criteria will be randomized to the aromatherapy or the placebo group after informed consent is obtained and immediately before undergoing the Hysteroscopy procedure. Sequentially numbered sealed opaque envelopes containing the identity of the study arm will be used for randomization. The Medical Plaza clinic nurse will prepare the aromatherapy versus distilled water on the paper towel with two drops of each utilized. Before the physician comes in, the nurse will ask the participant to take a deep breath while holding the towel 3 inches from her face and will instruct the participant to continue to take normal breaths subsequently. It will not be possible to blind the participants or the examiner to the assigned group since the lavender oil will have a different scent than the placebo. However, the use of distilled water on the towel will allow the possibility that the deep breathing accompanying the instruction may have an effect on reported pain and anxiety.

Vaginoscopy approach will be utilized to perform the procedure. This avoids the use of a speculum in the vagina or tenaculum to grasp the cervix. This is a atraumatic technique that reduces pain stimuli generated from the cervix and the vagina when using manipulating instruments. Vaginoscopy relies on hydrodilation of the cervical canal for entry of a small-caliber scope. This technique involves distending the vaginal vault with normal saline and advancing the scope to the posterior fornix. Gently pulling back until the external cervical os is visualized and then the scope is advanced into the cervical canal.

The participant will undergo the standard clinic exam in a standardized order. The participants will complete the Hospital Anxiety and Depression Survey (HADS) at baseline. The HADS (Appendix II) is a reliable instrument for detecting states of depression and anxiety in the setting of a hospital medical outpatient clinic; it is available in English and Spanish versions. This will be used to establish their baseline anxiety levels. Participants will then be asked to rate their level of anxiety and pain immediately before beginning the exam, immediately after hysteroscope placement, and 15 min after termination of the study using a 10-point visual analogue scale and the Wong-Baker pain scale. At the end, the participants will also be asked to rate their satisfaction with the visit overall on a visual analogue scale.
Hand antiseptic is applied by dispensing 1 pump into hands, spreading over the hands up to the wrist, and rubbing until dry. Hand antiseptic will be used twice approximately 15-30 minutes apart on one day.
<P>PROBLEM TO BE SOLVED: To provide an oral preparation for prevention and/or treatment of inflammation of a mucous membrane of the digestive tract of the mammals (especially human stomach) caused by the infection of Helicobacter species (particularly H. pylori).  <P>SOLUTION: The oral preparation comprises at least one kind of xanthophyll in a preventively and/or therapeutically effective amount. The most desirable xanthophyll is an oil-soluble astaxanthine, further preferably, a natural astaxanthine esterified by a fatty acid. The oral preparation may further comprise a carbohydrate structure such as the one derived from the cell wall of the producing alga Haematococcus. The oral preparation may comprise a preventively and/or a therapeutically effective amount of a water-soluble antioxidant such as ascorbic acid (vitamin C). The oral preparation is offered in a separated unit administration amount or in a mixture with food.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
In recent years, there has been a dramatic increase in the volume of endoscopic procedures performed in most endoscopy centers. With the growing awareness of colorectal cancer screening, there is increasing demand for colonoscopy which has increased the workload of endoscopists in every healthcare system. There are studies showing that physician fatigue impairs quality of care and performance in other medical specialties such as anesthesia and surgery. Colonoscopy by nature is repetitive and frequently prolonged which can promote distractibility and fatigability. Studies from western countries have showed that afternoon colonoscopies are associated with lower adenoma detection rate (ADR) compared with the morning colonoscopies and physician fatigue has been hypothesized as a potential contributor. Previous studies also showed that the polyp detection rate decreases hour-by-hour throughout the day and the colonoscopy completion rate appears to decline with successive procedures due to endoscopist fatigue. The most recent study using the queue position as a surrogate marker for endoscopist fatigue had showed that both the later colonoscopy start time and increasing number of preceding endoscopic procedures are associated with decreasing polyp detection rate. It is not surprising that endoscopist fatigue may contribute to a significant decline in the effectiveness of colonoscopy and yet it is probably not realistic to reduce the number of colonoscopy procedures per session given the heavy clinical demand. There have been no studies on any intervention that may improve the performance of colonoscopy. It would be reasonable to postulate that taking a break half way through the colonoscopy session may alleviate endoscopist fatigue and hence improve the polyp detection rate. This study aims to evaluate the effect of introducing a break in the middle of a colonoscopy session on the quality of colonoscopy performance.
PROBLEM TO BE SOLVED: To obtain an excellent ameliorant for alcohol metabolism and an excellent reducing agent for hepatopathy composed of natural components and safe in vivo. SOLUTION: The ameliorant for the alcohol metabolism and reducing agent for the hepatopathy are characterized as comprising a rice bran soybean fermenitation extract obtained by inoculating Bacillus natto or Bacillus subtilis into a culture medium containing rice brans, soybeans and carbon sources and carrying out fermentation and culturing. The rates of disappearance of ethanol and acetaldehyde in blood are increased and significantly higher hepatic alcohol dehydrgenase(ADH) and aldehyde dehydrogenase(ALDH) activities than those of the control group are found by ingesting the rice bran soybean fermentation extract. Thereby, the alcohol metabolism can be enhanced.  The rises in serum glutamic-oxaloacetic transaminase(GOT) and glutamic- pyruvic transaminase(GPT) activities accompanied by administration of the ethanol and carbon tetrachloride are suppressed and the suppression of formation of lipid peroxides(LPO) accompanied by the administration of carbon tetrachloride is observed. As a result, the hepatopathy due to the alcohol and carbon tetrachloride can be reduced.
At approximately 09:00 the subject will be given breakfast. After this, no food will be served until study procedures for the day are over. However, a 330 ml bottle of still water at room temperature will be given at \~11:00 and at \~13:00. During this period the subject will be required to remain in the unit.
The subjects in this arm will begin on the daily remote ischemic preconditioning (RIPC) protocol for 10 days. After a 21 day washout period they will then crossover to 10 days of daily exercise.
The present invention relates to a dietotherapeutic nutritive product of Chinese medicine for preventing and treating synchysis and a manufacturing method of the product. The product is made of official dietotherapeutic Chinese medicine comprises raw glycyrrhiza, cassia tora, Chinese wolfberry, chrysanthemum, etc. The present invention has the advantages of low production cost, no environment pollution, no difference for people and age, good taste, less dosage, certain effect and can be easily accepted by patients. Because eyes are windows of the soul and are the most important in five sense organs, all people want a pair of healthy eyes and good eyesight. However, nearly half of people in the world have eye diseases, and more than forty million people are blind. If no effective measure is adopted, the number of people having eye diseases can be multiplied, and each person can be threatened by the eye diseases. Posterior vitreous detachment caused by synchysis suddenly happens without any premonition, and particularly, the macular hole, the amotio retinae and the retinal vessel tearing phenomenon which seriously damage the most important central vision bring on vitreous hemorrhage and turbidity and bring on retina concurrency. Synchysis is easier to happen by growth of ages, high myopia and light irradiation for a long time. The present invention occupies an important position in the work of preventing and treating blindness. Thus, the present invention has important practical value and significance.
Patients will receive a total of 3 -three - injections of 75 IU Botulinum Toxin A in the proximal medial gastrocnemius muscle. Treatments will be performed by a specialist in neurology as a Ultra-Sound guided injection into the proximal medial gastrocnemius muscle Injections will be administered at baseline, 3 months and 6 months.
Usual Initial Dosage: 

Paroxetine tablets should be administered as a single daily dose with or without food, usually in the morning. The recommended starting dosage and the established effective dosage is 20 mg/day. In 1 clinical trial, the effectiveness of paroxetine tablets was demonstrated in patients dosed in a range of 20 to 50 mg/day. However, in a fixed dose study, there was not sufficient evidence to suggest a greater benefit for a dose of 40 mg/day compared to 20 mg/day. Dose changes, if indicated, should occur in 10 mg/day increments and at intervals of at least 1 week. 

Maintenance Therapy: 

There is no body of evidence available to answer the question of how long the patient treated with paroxetine tablets should remain on it. Although the efficacy of paroxetine tablets beyond 12 weeks of dosing has not been demonstrated in controlled clinical trials, PTSD is recognized as a chronic condition, and it is reasonable to consider continuation of treatment for a responding patient. Dosage adjustments should be made to maintain the patient on the lowest effective dosage, and patients should be periodically reassessed to determine the need for continued treatment.
To provide finger treatment materials that do not easily fall off the finger.SOLUTION: A finger treatment material 1 is a finger treatment material fixed to a finger having an affected part, comprising a support 10 and a plaster 20. The support 10 has a tubular shape with a closed end 10a. The finger is accommodated in the support 10 when the finger treatment material 1 is mounted. The support 10 has a notch 80. The plaster 20 is provided on the inner surface of the support 10. The plaster 20 is a portion that acts (action part) on the affected part.SELECTED DRAWING: Figure 1
OBJECTIVES: Migraine and tremor share some genetic mutation sites, and clinical studies have also confirmed their correlation. This study aims to explore the clinical and electrophysiological characteristics of migraine patients with concomitant tremor, and to analyze the relevant influential factors of tremor occurrence.
METHODS: We retrospectively analyzed the clinical data of 217 migraine patients who visited the Third Affiliated Hospital of Qiqihar Medical University from June 2022 to October 2023. The Clinical Rating Scale for Tremor (CRST), Numerical Rating Scale (NRS), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) were respectively used to assess the tremor symptoms, degree of headache, anxiety, and depression of patients. All patients underwent routine head MR scanning and electromyography examination, and were divided into a migraine with tremor group and a migraine without tremor group based on the electromyogram examination.
RESULTS: The migraine with tremor group and the migraine without tremor group were included 52 patients (23.96%) and 165 patients (76.04%), respectively. Compared with the migraine without tremor group, the migraine with tremor group had a longer course and duration of headache, higher frequency of headache attacks, higher NRS score, GAD-7 score, and PHQ-9 score, and fewer weekly physical exercises. The differences were statistically significant (all P<0.05). There were no statistically significant differences in the presence or absence of prodromal headache and white matter hyperintensities (WMHs) between the 2 groups (both P>0.05). The evaluation results of the CRST showed that out of 217 migraine patients, 39 patients (17.97%) were accompanied by tremors. The electromyographic results showed that all 52 migraine patients with tremors had upper limb tremors, including 28 migraine patients with postural tremors and 24 migraine patients with static tremors. Compared with the migraine patients with static tremors, the migraine patients with postural tremors had lower average frequency, peak frequency, and headache onset frequency (all P<0.05). Multiple linear regression analysis showed that frequency of physical exercise, duration of illness, frequency of headache attacks, NRS score, GAD-7 score, and PHQ-9 score were risk factors for migraine patients with concomitant tremors (all P<0.05).
CONCLUSIONS: Patients with migraine mainly experience upper limb postural tremors. Reduced physical exercise, long course of disease, long duration of headache, frequent headache attacks, severe headache, anxiety, and depression are risk factors for migraine patients with concomitant tremors.
In one variant, the invention provides a method of enhancing the activity of phagocytes including macrophages, and in a further variant, a method of modulating the cellular or humoral immune response to warm blooded animals. The invention also provides a method of reducing the adverse effects of stress in warm blooded animals. This is accomplished by administering an ethereally monosubstituted monosaccharide having the general formula M1-O-Y, an ethereal monosubstitution of monosaccharide derivatives having the general formula M2-O-Y, or pharmaceutically acceptable organic acid and inorganic acid salts thereof as defined hereinafter. In the first variant, the above substances are administered in an amount effective to enhance the microbicidal activity of phagocytes, including macrophages in a normal to depressed state of activation or macrophages already activated in response to infection. In the second variant, the above substances are administered in an amount to enhance the cellular or humoral immune response when the warm blooded animal has a normal or depressed cellular or humoral immune response system, or in an amount effective to reduce the cellular or humoral immune response when the warm blooded animal has a hypersensitive cellular or humoral immune response system. In the third variant, the above substances are administered in an amount effective to reduce the adverse effects of stress on the aforementioned defense mechanisms of warm blooded animals subjected to stress.
PROBLEM TO BE SOLVED: To obtain the subject suppresser capable of suppressing the oxidation of a low density lipoprotein (LDL), free from side effect and excellent in safety, and expected to be useful as a medicine for treating arteriosclerosis by compounding 2''-0glucosylisovitexine as an active component. SOLUTION: This suppresser contains 2''-O-glucosylisovitexine as an active component. The active component is preferable obtained by isolating is from a green juice of young leaves of barley Generally, 2''-O-glucosylisovitexine is preferably formulated into a preparation suitable for administration by compounding various pharmaceutically permissible additives. The additives include e.g. a nutrient such as ascorbic acid, a preservative such as benzoic acid, a carrier of a diluent such as methyl cellulose or lactose. Further, the daily dose of the objective suppresser is preferably 0.2-50mg/kg-body weight as the active component.
Peripheral nerve injury exacerbates progression of muscle heterotopic ossification (HO) and induces changes in expression of local cytokines in muscle tissue. The objective of the present study was to assess the impact of peripheral nerve injury on muscle HO development and the mechanism of cytokine modulation. A mouse model of gastrocnemius muscle HO was established and the sciatic nerve cut to simulate peripheral nerve injury. To evaluate the underlying factors contributing to the exacerbation of muscle HO resulting from denervation, fresh muscle tissue was collected and micro‑computed tomography, histochemical staining, RNA‑sequencing, reverse transcription‑quantitative PCR, Western blot, muscle tissue chip array were performed to analyze the molecular mechanisms. Sciatic nerve injury exacerbated HO in the gastrocnemius muscle of mice. Moreover the osteogenic differentiation of nerve‑injured muscle tissue‑derived fibro‑adipogenic progenitors (FAPs) increased in vitro. The expression of neuregulin 3 (NRG3) was demonstrated to be increased after nerve injury by muscle tissue chip array. Subsequent transcriptome sequencing analysis of muscle tissue revealed an enrichment of the PI3K/Akt pathway following nerve injury and an inhibitor of the PI3K/Akt pathway reduced the osteogenic differentiation of FAPs. Mechanistically, in vitro, peripheral nerve injury increased secretion of NRG3, which, following binding to ErbB4 on the cell surface of FAPs, promoted expression of osteogenesis‑associated genes via the PI3K/Akt signaling pathway, thus contributing to osteogenic differentiation of FAPs. In vivo, inhibition of the PI3K/Akt pathway effectively protected against muscle HO induced by peripheral nerve injury in mice. The present study demonstrated that the regulatory roles of NRG3 and the PI3K/Akt pathway in peripheral nerve injury exacerbated muscle HO and highlights a potential therapeutic intervention for treatment of peripheral nerve injury‑induced muscle HO.
This group will complete daily swallowing behavioral exercises with simultaneous at-home sEMG biofeedback using a tablet application. Participants will participate in weekly clinic visits and at-home therapy for 12 weeks.
The safety and effectiveness of single doses of ketorolac tromethamine injection have been established in pediatric patients between the ages of 2 and 16 years. Ketorolac tromethamine injection has been shown to be effective in the management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Safety and efficacy in pediatric patients below the age of 2 have not been established. Therefore, ketorolac tromethamine injection is not recommended in pediatric patients below the age of 2. The risk of bleeding was greater in those patients administered ketorolac tromethamine injection following tonsillectomy. Physicians should consider the increased risk of bleeding before deciding to administer ketorolac tromethamine injection in patients following tonsillectomy (see WARNINGS: Hemorrhage and Pediatrics and Tonsillectomy).

The risks identified in the adult population with ketorolac tromethamine injection use also apply to pediatric patients. Therefore, consult the CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS sections when prescribing ketorolac tromethamine injection to pediatric patients.
The invention relates to a traditional Chinese medicine mask for removing freckles and a preparation method. The mask is formed by mixing and blending active medicine powder and a blending liquid. The active medicine powder is prepared from, by weight, 1-3 parts of radix angelicae, 1-2 parts of rhizoma typhonii, 2-4 parts of white lilac, 2-4 parts of common bletilla tubers, 1-2 parts of radix ampelopsis, 1-2 parts of American ginseng, 1-2 parts rose flowers, 1-2 parts of pearls and 1-2 parts of lithargite. The blending liquid is one or mixed liquid of more of towel gourd juice, cucumber juice, aloe juice and honey. According to the mask, radix angelicae, rhizoma typhonii, white lilac, common bletilla tubers and radix ampelopsis are adopted as monarch drugs, and the functions of whitening the face and removing freckles are achieved. American ginseng, rose flowers and pearls are adopted as ministerial drugs, and the functions of promoting blood circulation, nourishing skin and the like are achieved. Lithargite is adopted as an auxiliary drug, and the functions of inhibiting eczema and anabrosis and the like are achieved. The drugs are in compatibility according to assistant and guide, all the drugs achieve a synergistic effect, the effects of whitening the face, removing freckles, activating blood to remove blood stasis, tonifying skin and the like are achieved, freckles and chloasma can be effectively treated, and a whitening function is achieved.
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) significantly impacts the quality of life of cancer patients undergoing treatment, often leading to treatment interruptions and compromised adherence to therapy. Our objective was to identify patterns for selecting the optimal acupoints and explore the treatment principles behind forming effective acupoint combinations for CINV.
METHODS: Clinical trials were retrieved from eight databases. Descriptive statistics analysis was performed, followed by association rule mining, network analysis, hierarchical cluster analysis, and correlation analysis, all implemented with R software.
RESULTS: In summary, this study investigated the potential acupoints and combinations for CINV treatment in 104 published controlled clinical trials and randomized controlled trials. 104 prescriptions involving 48 acupoints were extracted. ST36, PC6, CV12, SP4, LI4, and ST25 appeared to be the most frequently used acupoints for CINV. Stomach Meridian, Conception Vessel (Renmai), and Pericardium Meridian were the most common selected meridians. The lower limbs, chest, and abdomen appeared as the predominant sites for acupoint selection. Co-occurrence network analysis indicated that ST36, PC6, and CV12 were central key node acupoints. The clustering analysis displayed the treatment principle of "harmonizing the stomach, stopping vomiting, and descending counterflow." Association rule mining revealed that the combination of CV4, CV12, ST36, CV6, and PC6 emerged as the optimal acupoint combination for effectively treating CINV.
CONCLUSION: Overall, our research provides evidence-based optimal acupuncture prescription for acupuncturists to treat CINV and presents a complementary therapy for chemotherapy physicians as well as patients to address CINV symptoms.