1502680 Compositions for stimulating physiological cold-receptors WILKINSON SWORD Ltd 2 June 1976 [3 June 1975] 23947/75 Heading A5B [Also in Divisions A2, C2, C5 and C6] Products for application or consumption by the human body contain in an amount effective to stimulate the cold receptors of the nervous system of the body when brought into contact therewith upon use of the product, a compound of the formula RX wherein R is a saturated or monoethylenically unsaturated bicyclic hydrocarbon radical containing a total of 8 to 12 carbon atoms and selected from [3.3.1] bicycloheptanes, [2.2.1] bicycloheptanes and hept-5-enes and [2.2.2] bicyclooctanes and oct-5-enes containing 1 to 3 C 1-5  alkyl substituents; and X is a CH 2 OH, COOH, COOR 1  or CONR 2 R 3  group attached to said bicyclic radical at a 2-position, wherein R 1  is a hydroxyalkyl or hydroxyalkoxyalkyl radical of 2-4 carbon atoms. R 2  taken separately is H or C 1-5  alkyl: R 3  taken separately is H, C 1-5  alkyl, C 1-5  hydroxyalkyl or C 3-6  alkoxycarbonylalkyl with the proviso that when R 1  is H, then R 2  may also be C 3-6  cycloalkyl, phenyl or phenyl containing up to 2 hydroxy, methyl or methoxy substituents; and R 2  and R 3  when taken together, represent a C 4-5  alkylene group, the carbon chain of which may optionally contain an ether oxygen atom, and forming with the nitrogen to which they are attached, a piperidine pyrrolidine or morpholino group. The products may be personal care products e.g. a cosmetic, toilet lotion or dentifrice, or cleansing preparations such as soap or detergent compositions, or impregnated cleansing tissues, or toothpicks; or may be edible or potable products such as chewing gums and flavoured drinks; or smoking compositions or products e.g. tobacco compositions, cigarettes and filter - tipped cigarettes; or pharmaceutical compositions containing a pharmaceutically active ingredient. Examples are given for the following products containing compounds of formula RX as defined above: Example 14:- After shave lotion comprising ethanol, diethyl phthalate, perfume, propylene glycol and water; Example 15:- Cleansing tissue impregnated with glycerine perfume, water and triethanolamine lauryl sulphate; Example 16:- Toothpaste; Example 17:- Aerosol foaming shaving soap comprising stearic and lauric acids, triethanolamine and water in a butane propellant; Example 18:- Hair shampoo containing sodium lauryl ether sulphate; Example 19:- An impregnated toothpick; Example 20:- Soft drink concentrate of orange flavour. orange juice, saccharin, sugar, preservative and water; Example 21:-ethanolic toilet water; Example 22:- A soft sweet of icing sugar: Example 23:- Hydrophilic ointment; Example 24:- Deodorant composition of hexachlorophene in a perfumed base: Example 25:- Lipstick: Example 26:- Solid cologne; Example 27:- Hair tonic; Example 28:- Mouthwash composition; Example 29:- Talcum powder; Example 30:- Chewing gum; Example 31:- Impregnated tobacco: Example 32:- an impregnated tip for a filter-tipped cigarette. Other compositions or products described include alcoholic beverages, ice cream, jellies, bath oils and salts, sunburn lotions, eyedrops, medicaments which may be topical or internal (e.g. antacid preparation of sodium or magnesium carbonates, aluminium or magnesium hydroxides or trisilicates; and aspirin or ephedrine compositions), tobacco products such as cigarettes and pipe tobacco, chewing tobacco and snuff; and miscellaneous preparations such as water soluble adhesives for envelopes, labels and postage stamps.