anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Coronary artery disease is defined by the existence of atherosclerotic plaque on the arterial wall, which can cause blood flow impairment, or plaque rupture, and ultimately lead to myocardial ischemia. Intravascular ultrasound (IVUS) imaging can provide a detailed characterization of lumen and vessel features, and so plaque burden, in coronary vessels. Prediction of the regions in a vascular segment where plaque burden can either increase (progression) or decrease (regression) following a certain therapy, has remained an elusive major milestone in cardiology. Studies like IBIS-4 showed an association between plaque burden regression and high-intensity rosuvastatin therapy over 13 months. Nevertheless, it has not been possible to predict if a patient would respond in a favorable/adverse fashion to such a treatment. This work aims to (i) Develop a framework that processes lumen and vessel cross-sectional contours and extracts geometric descriptors from baseline and follow-up IVUS pullbacks; and to (ii) Develop, train, and validate a machine learning model based on baseline/follow-up IVUS datasets that predicts future percent of atheroma volume changes in coronary vascular segments using only baseline information, i.e. geometric features and clinical data. This is a post hoc analysis, revisiting the IBIS-4 study. We employed 140 arteries, from 81 patients, for which expert delineation of lumen and vessel contours were available at baseline and 13-month follow-up. Contour data from baseline and follow-up pullbacks were co-registered and then processed to extract several frame-wise features, e.g. areas, plaque burden, eccentricity, etc. Each pullback was divided into regions of interest (ROIs), following different criteria. Frame-wise features were condensed into region-wise markers using tools from statistics, signal processing, and information theory. Finally, a stratified 5-fold cross-validation strategy (20 repetitions) was used to train/validate an XGBoost regression models. A feature selection method before the model training was also applied. When the models were trained/validated on ROI defined by the difference between follow-up and baseline plaque burden, the average accuracy and Mathews correlation coefficient were 0.70 and 0.41 respectively. Using a ROI partition criterion based only on the baseline's plaque burden resulted in averages of 0.60 accuracy and 0.23 Mathews correlation coefficient. An XGBoost model was capable of predicting plaque progression/regression changes in coronary vascular segments of patients treated with rosuvastatin therapy in 13 months. The proposed method, first of its kind, successfully managed to address the problem of stratification of patients at risk of coronary plaque progression, using IVUS images and standard patient clinical data.
Implants made of biodegradable polymers are replaced by regenerating tissues through inflammation. The changes occurring in tissues and the organism are of practical interest for studying the biocompatibility of the material and searching for systemic markers in the blood that reflect inflammation in peri-implantation tissues. The highly sensitive C-reactive protein (hs-CRP) measurements in blood and morphometric studies of tissue surrounding the implant were carried out in the experiment within three months of implantation of a biopolymer consisting of polycaprolactone (PCL) and polytrimethylene carbonate (PTMC). During the first month, tissue inflammation decreased, and the blood level of hs-CRP did not increase. The polymer biotransformation began in the tissues after a month of implantation and was accompanied by inflammation moving deeper into the matrix. Proliferation of inflammatory cells in tissues was reflected in an increase in the hs-CRP level three months after polymer installation. The result achieved confirmed the polymer's bioinertness. The level of hs-CRP in the blood of the animals correlated with the level of inflammation in peri-implantation tissues, reflecting the activity of inflammation in the process of polymer biotransformation. This inflammation protein can be recommended for assessing tissue processes following implantation of biopolymers and their biocompatibility.
The CRISPR/Cas9 gene-editing technique is taking the scientific research and healthcare community by storm with the promise it holds to cure and ease the burden of debilitating diseases. However, there is limited knowledge regarding the implications of using this type of tool in human research and medicine. Researchers need to understand the viewpoints of patients, their families, and their providers, to ensure that the approach taken towards gene-editing is inclusive and respectful of different interests and concerns. The dialogue, thus far, has been dominated by scientific researchers, physician scientists, ethicists, public health and policy experts. It is important to the advancement of the science to study the patient s perspective about the use of the technology. In addition, parents often play important roles in the decision-making process; in this regard, understanding the views and questions of this group of individuals regarding CRISPR/Cas9 human use is essential. We conduct a qualitative study with a mixed methods component to investigate the knowledge, attitudes and beliefs of patients living with sickle cell disease (SCD), the parents of patients with SCD, and the physicians of this patient population regarding the use of CRISPR/Cas9 technology. The study is designed to measure these three cohorts baseline overall genetic literacy, CRISPR-specific literacy, and general attitudes and beliefs toward gene-editing/CRISPR Cas9(in both somatic and germline cells); to evaluate the utility of an educational tool in improving one s understanding of this innovative technique; and to gauge how attitudes and beliefs toward gene-editing, specifically CRISPR Cas9, perhaps shift or remain intact after the educational video, as well as within a focus group space.
The disclosure provides CTL epitopes of African swine fever (ASF) and applications thereof, belonging to the technical field of peptide vaccine preparation. According to the 5 disclosure, African swine fever virus (ASFV) peptides that can be stably bound to MHC class I are screened by bioinformatics methods and in vitro methods for identifying MHC Ibinding motifs. The screened peptides are capable of initiating CD8+ T cells to generate immune response and stimulating the body to speciﬁcally generate CTL. The amino acid sequence of the peptides is set forth in any one of SEQ ID No: 1-18. The peptide provided 10 by the disclosure can be used for preparing specific epitope vaccine or peptide vaccine of ASF. It has high safety and good specificity, and has potential application value in preventing and controlling African swine fever.
FIELD: medicine, ultrasonic diagnosis. SUBSTANCE: colloidal dispersions of type "liquid-in-liquid", i. e. emulsions or microemulsions where the dispersed phase is a liquid and exhibiting boiling point lower of an animal body temperature and image of this animal is necessary to obtain are subjected for phase change from the dispersed liquid to the strongly echogenic dispersed gas-like phase or kugelshaum after administration to animal. Liquid state of the dispersed phase ensures to prepare very stable pharmaceutically acceptable emulsions exhibiting particle size below 1000 nm usually. As a result of conversion of the dispersed phase to the gas-like state at temperature body the highly echogenic microvesicles are formed (their diameter is below 10000 nm usually) which are effective as ultrasonic contrasting agents. Invention describes the dosed forms for intravenous, intra-arterial, for oral, intraperitoneal and intrauterine administration, methods of administration and methods of image making. EFFECT: improved ultrasonic diagnosis. 28 cl, 9 tbl, 56 ex
Each year, more than 1.7 million new cancer patients in the U.S. undergo intense, multimodal treatments that that create numerous logistical challenges in managing treatment and everyday life priorities. In the current cancer care system, "logistic toxicity"-the toxic effects imposed by the logistical burden of carrying out cancer treatment-related tasks on patient well-being-has been largely unmeasured and unaddressed. Current methods for measuring logistic toxicity generate retrospective assessments intended for researchers. They do not offer timely information that empower patients to solicit assistance from care providers, employers, family, and friends. Nor do they empower providers to explore the increasingly available treatment options for patient- centered cancer care. This proposal aims to apply a new method-app-assisted day reconstruction-to develop the first digital health tool to enable remote patient monitoring of logistic toxicity, which is the necessary first step towards developing effective care interventions for addressing it.

Our product is both conceptually and technically innovative. Conceptually, the investigators apply the day reconstruction method-a method initially created by well-being researchers for collecting more accurate data on daily life experiences-to collect activity engagement and well-being information related to cancer treatment tasks. Technically, the investigators leverage the existing patented technology and new machine learning techniques to enable novel integration of objective mobile sensing with subjective patient input. Mobile sensing and machine learning will constitute the "assist" that the app provides for day reconstruction in relation to logistic toxicity, significantly reducing recall errors and the need for manual input. The "assist" will also prompt patients to provide information such as subjective well-being ratings that are not detectable by mobile sensing or machine learning, generating more accurate and comprehensive measures of logistic toxicity than existing methods.

The project has three specific aims, including (1) an initial system design based upon input from cancer patients and cancer care stakeholders, (2) prototype development and initial tests, and (3) field tests of the app among 60 diverse patients undergoing treatment for cancer. In Aim 3, patients will rate the quality of the app using the Mobile App Rating Scale (MARS) and their satisfaction with the three key app features: 1) the app's ability to capture out-of-home treatment-related activities and trips, 2) the ease of the interface for inputting home-based treatment-related activities and well-being ratings, and 3) the usefulness of the logistic toxicity summary report. The outcome of this project will be a final prototype app with 70% of patients indicating an overall MARS score of 4.0 or more and satisfaction with the three features. In Phase II, the team will test the efficacy of the app-both separately and in conjunction with care coordination, telemedicine, and home-based treatments-in reducing logistic toxicity and improving treatment outcomes in a randomized controlled trial.
PURPOSE:To obtain a dentifrice composition having excellent sterilizing power and preservation stability for a long period by using povidone iodine alone or adding KI and/or NaI or further NaCl and/or KCl or l-menthol thereto so as to enhance stability. CONSTITUTION:A dentifrice composition containing about 0.001-5.0wt.% povidone iodine. Potassium iodide or sodium iodide or both in an amount of 0.5-5.0wt.% are preferably contained in the aforementioned composition. Furthermore, sodium chloride and/or potassium chloride in an amount of 1.0-3.0wt.% can be contained to further enhance the stability. A perfume, l-menthol in an amount of 0.01-2.0wt.% is preferably contained in order to reduce smell of bromine and enhance feeling of use in using the dentifrice. The aforementioned composition is excellent in sterilizing power with extremely low toxicity to human bodies.
A computing system receives, from a user device, a request to generate an estimated activity profile for a user of the user device for a workout. The computing system identifies route information for the workout. The computing system generates, via a trained prediction system, an initial estimated heartrate for the user based on a personalized training process for the user. The computing system generates, via the trained prediction system, a duration of a portion of the workout based on the route information and environmental information associated with a time and day of the workout. The computing system generates, via the trained prediction system, a projected heartrate of the user during the workout based on the initial estimated heartrate of the user and the generated duration. The computing system outputs the estimated activity profile corresponding to the workout based on the projected heartrate of the user.
310,855. Maynes, H. F., and Maymes, E. C., (Assignees of Zebulske, E. A.). May 1, 1928, [Convention date]. Coatings for medicines; pillmaking appliances.-A process for coating finely divided material with a liquid coating comprises forming a spray of the coating liquid by means of compressed air, introducing the divided material into the spray, and maintaining the coated particles in suspension until the coating has dried or hardened. The application of the process to coating medicinal pills or pellets with chocolate, sugar, or other suitable coating material is referred to. As shown in Figs. 1 and 2, the apparatus is designed for coating a dried mixture of milk and sugar contained in a receptacle S, with chocolate that is liquified in a pressure kettle K. The liquified chocolate is forced by air under pressure through a pipe 9 to the inner nozzle 26 of a mixing device N, the powdered material being supplied through a pipe 2 to the mixing chamber 36. Compressed air from the pipe 15 is supplied to the kettle through a pipe 11, and to the member N through pipes 13, 14. When the valves 42, 43 are opened to admit compressed air through the pipes 14, 13 to the mixing nozzle, the needle valve 44 being open, the molten chocolate delivered through the tube 26 is converted into a fine spray by the compressed air issuing from the tube 21, this spray being carried out of the nozzle through orifices 30, 37. The cut-off valve 48 of the pipe 2 is then opened, and the partial vacuum that exists in the mixing chamber 36 induces a flow of material to be coated from the container 1. The supply of this material is regulated by the provision of openings 38 through the mixing chamber to the atmosphere, As the spray of coated material leaves the mixing chamber 34, 36 a converging annular blast of air delivered through the pipe 41 to the sleeve 39 surrounding the cap 35 serves to narrow the stream of spray and avoid its contact with the walls of the drying chamber D before the chocolate has become dried or set. The velocity of the stream of spray is reduced owing to the diverging walls 54 of the chamber D and the dried coated material is received by the canveyer 55. In the mixing nozzle N the tube 26 is centred by a screw 27 having a spring mounting 28, and the tube 21 is provided with openings 31 through which the compressed air passes to the interior of the cap 29. The injector action of the nozzle may be used to supply the granular material and the coating material without a gravity feed for the material in the container 1 or the use of compressed air to the chocolate container K. According to a modified arrangement which is illustrated, the mixing and spraying nozzle N is arranged horizontally, the coated material being sprayed into a hopper supplied with compressed air by rotary blower and received in a separator.
FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to biologically active compounds showing selective inhibitory effect on M-cholinoreactive systems and weakly SUPPRESSING the central nervous system activity. Invention describes the novel compounds: substituted aminobutynol hydrochlorides of the general formula (Ib-IVb)   where R is  ; NR       1   2        is  . The above indicated aminoalcohols are active and have low toxicity of M-cholinolytics of central effect, their activity exceeds that the known the most effective preparations but their effect on central nervous system is weaker. EFFECT: new compounds indicated above, valuable medicinal properties. 3 tbl
PURPOSE OF REVIEW: The aim of this review is to examine published reports of neurodevelopmental phenotypes in patients with inborn errors of immunity (IEI). We briefly discuss potential interactions between the immune and the central nervous system and the implications of this crosstalk for current clinical management guidelines.
RECENT FINDINGS: An increasing number of reports have described neurodevelopmental disorders (NDDs) comorbid with immune-mediated signs. However, the prevalence of this association in IEIs remains unknown.
SUMMARY: IEIs comprise a group of clinically heterogeneous disorders associated with a number of nonimmune comorbidities. Although certain neurological conditions such as microcephaly are recognized as associated features of some IEIs, NDDs are less well described. We reviewed published clinical descriptions of IEIs and found a number of comorbid NDDs in these patients, including autism spectrum disorder (ASD), behavioral deficits, and intellectual disability. Given the lack of uniform assessments for NDDs, we suspect they may be underdiagnosed in IEIs. As NDDs manifest early and can result in life-long cognitive and emotional deficits, which diminish quality of life and increase healthcare utilization, we hope to elucidate relevant pathomechanisms and raise clinician awareness of these comorbidities so appropriate and timely interventions are sought.
Prevention and treatment of the reversible childhood blindness, including congenital cataracts (CC), has been listed as a significant component of the international programme "VISION 2020 - the Right to Sight" launched by WHO in 1999. However, there is still a lot of unsolved problems regarding to CC, especially in developing countries, such as the delayed presentation and treatment to the hospitals, the lack of specialized treatment departments, and the poor treatment prognosis. With the two children policy opened in China in 2016, many CC parents hesitate to have a second child due to the potential high risk of CC. Date on detailed clinical characteristics of the CC children, including the demography, pregnancy-labor history, and living condition, are crucial for developing the national screening strategies of CC in Pregnant women. However, to our knowledge, it still lacks of thus large population-based and comprehensive investigations of the characteristics of CC children in developing countries. Supporting by the National Ministry of Health and the Zhongshan Ophthalmic Center (ZOC), a specialized eye facility with the largest CC database in China, we therefore comprehensively investigated the demography, pregnancy-labor history, and living condition of CC children with their first visits to the hospital. We also further established a mathematic model of non-genetic risk factors of congenital cataracts. The implications of this study will be of clinical importance to roughly predict the risk of CC in pregnant women.
Background and Aim: There is limited evidence to support the relationship between dietary patterns and metabolic phenotypes. Therefore, this study aimed to assess the association of dietary patterns with metabolic phenotypes among a large sample of Iranian industrial employees. Methods: This cross-sectional study was conducted among 3,063 employees of Esfahan Steel Company, Iran. Using exploratory factor analysis, major dietary patterns were obtained from a validated short form of food frequency questionnaire. The metabolic phenotypes were defined according to Adult Treatment Panel III guidelines. The independent-sample t-test, one-way analysis of variance, χ2 test, and multivariable logistic regression were applied to analyze data. Results: Three major dietary patterns were identified by factor analysis: the Western dietary pattern, the healthy dietary pattern, and the traditional dietary pattern. After controlling for potential confounders, subjects in the highest tertile of Western dietary pattern score had a higher odds ratio (OR) for metabolically healthy obese (MHO; OR 1.58, 95% confidence interval [CI]: 1.29-1.94), metabolically unhealthy normal weight (OR 1.93, 95% CI 1.08-3.45), and metabolically unhealthy obese (MUHO) phenotypes (OR 2.87, 95% CI 2.05-4.03) than those in the lowest tertile. Also, higher adherence to traditional dietary pattern was positively associated with a higher risk of MHO (OR 1.91, 95% CI 1.56-2.34) and MUHO phenotypes (OR 2.33, 95% CI 1.69-3.22) in the final model. Conclusion: There were significant associations between dietary patterns and metabolic phenotypes, suggesting the necessity of nutritional interventions in industrial employees to improve metabolic phenotype, health outcomes, and, therefore, job productivity in the workforce population.
PURPOSE: Repeated ankle sprains can lead to chronic lateral ankle instability (CLAI). It is unclear whether CLAI causes pain unless complicated by intra-articular lesions. This study aimed to analyze the characteristics of pain and the relationship between pain and intra-articular pathology in patients with CLAI.
MATERIALS AND METHODS: Fifty-three ankles in 46 patients with CLAI who had undergone surgery were retrospectively reviewed. The self-administered foot evaluation questionnaire (SAFE-Q) was given to patients the day before surgery. Intra-articular lesions were assessed using arthroscopy and magnetic resonance imaging (MRI). In addition, the Hounsfield Unit (HU) on computed tomography (CT) of the medial gutter was measured. The relationship between pain and intra-articular findings was also analyzed.
RESULTS: The pain and pain-related scores in the SAFE-Q were significantly correlated with synovitis in 96.3% (rs = - 0.532). HU ratios in the tibia and talus were also significantly correlated with pain (rs = - 0.603, - 0.534, respectively). The arthroscopic synovitis score and HU ratios in patients with high pain scores were significantly higher than those in patients with low pain scores. Forty ankles (75.5%) had synovitis and articular cartilage injuries were observed in 22 ankles (41.5%). Patients with fluid collection or bone marrow lesions (BML) scored significantly lower in pain than those without, but there was no significant difference between patients with and without cartilage injury. Multiple regression analysis revealed that a high synovitis score and HU ratio of the talus were significantly associated with high pain.
CONCLUSIONS: Intra-articular lesions such as synovitis and BML were associated with pain in patients with CLAI. Osteosclerotic changes in the medial gutter also induced ankle pain, indicating that osteoarthritic changes had already begun. Therefore, lateral ankle ligament injuries after ankle sprain should be appropriately treated to avoid secondary degenerative changes.
Cognitive Intervention Tasks Participants will be asked to perform the Brain Fitness (PositScience) cognitive training tasks an hour each day, five days per week for 8-10 weeks. Six tasks manipulating auditory and verbal information will be presented, and stimuli from all tasks are presented auditorily. All tasks are designed to begin with the lowest level of difficulty required to attain 85% accuracy, and as performance improves, difficulty increases to maintain 85% accuracy, with difficulty decreasing if accuracy decreases.