anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Deep brain simulation (DBS) is an increasingly popular treatment for movement and psychiatric disorders such as Parkinson's disease and dystonia. These patients are quite sensitive to anesthetics and use of depth of anesthesia monitors are often needed to titrate the anesthetics. The calibration of BIS and entropy monitors has been done only on subjects with no neurological diseases. The investigators plan to record BIS and entropy readings during general anesthesia (GA) for the internalization of DBS electrodes. This would be useful as there are very few studies in this subset of patients with regards to DOA monitoring. Ashraf argued that the EEG may be altered under these circumstances and hence produce invalid BIS readings. Pemberton et al. studied patients undergoing tumour surgery using a sleep- awake-sleep anaesthesia technique. They found a poor correlation between BIS values and the observer's assessment of anesthesia level, suggesting that BIS is not a reliable tool for patients with brain abnormalities. The purpose of this study was to investigate whether BIS and entropy are helpful in titrating DOA in patients undergoing neurosurgical procedures or suffering from neurological diseases as they were frequently excluded from validation studies of the BIS monitoring device.
Obesity is one of the major public health issues of this century. Over the last decade, the prevalence of obesity has increased globally, making it an emerging epidemic and threatening the survival of health care systems. Obesity has long been recognized as the major factor predisposing to cardio-metabolic diseases.The positive role of structured exercise for reducing the mortality and morbidity rates of obese and sedentary adults is well established. But exercise engagement is seen to be quite low in obese adults mainly due to lack of time and non-adherence to exercise training programs. Current trends are now focusing towards another type of exercise regime known as high intensity interval training (HIIT), which is composed of repetitive short to long (\< 45 sec to 4 min) bouts of high intensity exercise alternating with rest or recovery periods. Resistance training can also stimulate changes in body composition indices as well as maintain the reduced fat mass after training. Thus resistance exercises are recommended as an adjunct for obesity management by reduction in risk factors. Hence, this study is designed to determine the effects of high intensity interval training in combination with resistance exercises verses moderate intensity continuous training on multiple outcome variables including body composition parameters, visceral adiposity, lipid profile and myocardial function in overweight and obese adult population of Pakistan. Afte r obtaining written informed consent from paricipants, they will be screened using 2020 PAR-Q plus and randomly allocated to one of the 2 groups. A self-structured demographic sheet would be employed for recording demographics and required data including the findings of lab investigations. Then participants will be required to undergo all the physical assessment measures such as anthropometric data, 6 minute walk test, lipid profile, body composition analysis and echocardiography. Physical activity levels and QOL would be assessed by filling IPAQ and SF 36 respectively. Exercise training plans would be performed thrice a week on alternate days for a total duration of 10 weeks. All measurements (anthropometric, cardiac, blood and body composition analyses) would be performed at baseline and later after the 10 weeks intervention period. Exercise intensity will be determined by individualized target heart rate zones using Karvonen formula. Strength training intensity will be determined based on 1-RM. Necessary adjustments to speed/grade and resistance will be made over the course of the intervention to ensure that target heart rate zones are achieved at all times. Apart from the exercise programs, a general similar dietary guidance by a nutritionist would also be provided to both of the groups to avoid unhealthy dietary habits.
Patients undergo surgery per standard of care. Within 10-30 days after surgery, patients undergo stereotactic radiosurgery for 1 fraction.
NebMag group (n=20) was administered nebulized isotonic magnesium (64 mg/mL). For nebulization, an isotonic MgSO₄ solution (64 mg/mL) was formulated by diluting a 10% intravenous preparation of MgSO₄ heptahydrate with sterile distilled water. 4 mL aliquots of the isotonic MgSO₄ solution (containing 256 mg of MgSO₄) were administered every 15 minutes through the jet nebulizer connected to the ventilator during the 24 hour study period.
PCT No. PCT/SE95/00064 Sec. 371 Date Jul. 17, 1996 Sec. 102(e) Date Jul. 17, 1996 PCT Filed Jan. 24, 1995 PCT Pub. No. WO95/19775 PCT Pub. Date Jul. 27, 1995The invention relates to an inositol phosphate containing pharmaceutical composition which comprises an aliphatic ester or ether for improvement of the bioavailability of the inositol phosphate in mammals including man at non-parenteral administration. The invention also covers the use of at least one aliphatic ester or ether compound for the preparing of an inositol phosphate containing medicament with improved bioavailability of inositol phosphate in mammals including man at non-parenteral administration.
Disclosed is a traditional Chinese medicine formula for treating viral keratitis. The formula is characterized by comprising components of: 20g of each of stamen nelumbinis, sparrow droppings, wild chrysanthemum flower, and polygala tenuifolia; 18g of each of notopterygium root, folium isatidis, blighted wheat and dried orange peel; 15g of each of fructus tribuli, sharpleaf galangal fruit, and motherwort fruit; 12g of each of dried radix rehmanniae, rheum officinale, fructus forsythia, and schizonepeta; 10g of each of mulberry leaf, raw artemisia argyi, and raw rhubarb; 8g of each of cordate houttuynia, arisaema heterophyllum, and rhizoma arundinis donacis; and 5g of isatis root. An application method comprises: grinding the medicinal materials into fine powder according to a ratio; adding a proper amount of honey for uniform mixing; externally applying 10g of the mixed medicine to a temple ipsilateral to the eye with viral keratitis, and covering the temple with gauze; and changing the medicine once a day. One treatment course is five days. According to the invention, problems that the existing conventional traditional Chinese medicine formula for treating viral keratitis is unsatisfactory in a therapeutic effect and long in therapy time; the viral keratitis is hard to cure and easily recurs; and there will be a risk of blindness for improper use of the medicine are overcome. The traditional Chinese medicine formula in the invention is suitable for treating viral keratitis.
Atherosclerosis is a lipoprotein-driven disease, and there is no effective therapy to reverse atherosclerosis or existing plaques. Therefore, it is urgently necessary to create a noninvasive and reliable approach for early atherosclerosis detection to prevent initial plaque formation. Atherosclerosis is intimately associated with inflammation, which is accompanied by an excess of reactive oxygen species (ROS), leading to cells requiring more glutathione (GSH) to resist severe oxidative stress. Therefore, the GSH-hydrolyzed protein γ-glutamyl transpeptidase (GGT) and the ROS-hypobromous acid (HBrO) are potential biomarkers for predicting atherogenesis. Hence, to avoid false-positive diagnoses caused by a single biomarker, we constructed an ingenious sequence-activated double-locked TP fluorescent probe, C-HBrO-GGT, in which two sequential triggers of GGT and HBrO are meticulously designed to ensure that the probe fluoresces in response to HBrO only after GGT hydrolyzes the probe. By utilization of C-HBrO-GGT, the voltage-gated chloride channel (CLC-1)-HBrO-catalase (CAT)-GGT signaling pathway was confirmed in cellular level. Notably, the forthcoming atherosclerotic plaques were successfully predicted before the plaques could be observed via the naked eye or classical immunofluorescent staining. Collectively, this research proposed a powerful tool to indicate the precise position of mature plaques and provide early warning of atherosclerotic plaques.
NAPROSYN (naproxen) tablets, EC-NAPROSYN (naproxen) delayed-release tablets and ANAPROX DS (naproxen sodium) tablets are nonsteroidal anti-inflammatory drugs available as follows:

NAPROSYN tablets are available as yellow tablets containing 500 mg of naproxen for oral administration.

EC-NAPROSYN delayed-release tablets are available as enteric-coated white tablets containing 375 mg of naproxen or 500 mg of naproxen for oral administration.

ANAPROX DS tablets are available as dark blue tablets containing 550 mg of naproxen sodium for oral administration.

Naproxen is a propionic acid derivative related to the arylacetic acid group of nonsteroidal anti-inflammatory drugs. The chemical names for naproxen and naproxen sodium are (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid and (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid, sodium salt, respectively. Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen sodium has a molecular weight of 252.23 and a molecular formula of C14H13NaO3. Naproxen and naproxen sodium have the following structures, respectively:

Naproxen is an odorless, white to off-white crystalline substance. It is lipid-soluble, practically insoluble in water at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of naproxen at pH 7.4 is 1.6 to 1.8. Naproxen sodium is a white to creamy white, crystalline solid, freely soluble in water at neutral pH.

The inactive ingredients in NAPROSYN tablets include: croscarmellose sodium, iron oxides, povidone and magnesium stearate. 

The inactive ingredients in EC-NAPROSYN delayed release tablets include: croscarmellose sodium, povidone and magnesium stearate. The enteric coating dispersion contains methacrylic acid copolymer, talc, triethyl citrate, sodium hydroxide and purified water. The imprinting on the tablets is black ink. The dissolution of this enteric-coated naproxen tablet is pH dependent with rapid dissolution above pH 6. There is no dissolution below pH 4.

The inactive ingredients in ANAPROX DS tablets include: magnesium stearate, microcrystalline cellulose, povidone and talc. The coating suspension may contain hydroxypropyl methylcellulose 2910, Opaspray K-1-4227, polyethylene glycol 8000 or Opadry YS-1-4216.
A device, a system and a method for collecting and judging patient behavior information are disclosed. The system includes a device and a server for collecting and judging patient behavior information. The device for collecting and judging patient behavior information includes a thermal energy sensing module, a network module, an operation module, and a power management module. The thermal energy sensing module is used to sense thermal energy information of a patient and his surrounding. The network module is used to receive the patient's background information through a network from the server. The operation module is used to determine the current and upcoming behaviors of the patient according to the preset behavior model and based on the thermal energy information and the background information. The operation module also sends notification signals to the server based on the behavior, and the power management module is used to supply power required for operation.
The data of study was obtained by using online questionnaire. The questionnaire was generated through Google forms and the online questionnaire link was delivered via e-mail to office workers. The questionnaire link was active within 3 months for data collection. The information about study was stated and before answering the questionnaire, all participants were asked whether they were willing to participate in the study and thus all participants have declared voluntary for the study. All participants were employees such as clerical or administrative work in an office. The inclusion criteria were as follows; (a) being an office worker or remote employee; (b) aged between 18 and 55 years; (c). had a diagnosis with myofascial pain in neck. The exclusion criteria were as follows: (a) having a history of surgery in neck region; (b): a diagnosis with skeletal muscle diseases, chronic kidney diseases, chronic liver failure, malignancy and neurologic diseases; (c): having cognitive impairment that affects answering the online questionnaire properly; (d): having internet access and not being able to complete the online questionnaire; (e): being pregnant. The Beck Depression Inventory (BDI), The Nottingham Health Profile (NHP), Neck Pain and Disability Scale (NPDS), Pittsburgh Sleep Quality Index (PSQI), The Nottingham Health Profile (NHP) and demographic form were obtained
The safety and effectiveness of daptomycin for injection in the treatment of cSSSI and S. aureus bloodstream infections (bacteremia) have been established in the age groups 1 to 17 years of age. Use of daptomycin for injection in these age groups is supported by evidence from adequate and well-controlled studies in adults, with additional data from pharmacokinetic studies in pediatric patients, and from safety, efficacy and PK studies in pediatric patients with cSSSI and S. aureus bloodstream infections [see Adverse Reactions (6.1), Clinical Pharmacology (12.3), and Clinical Studies (14.1, 14.2)]. 

Safety and effectiveness in pediatric patients below the age of one year have not been established. Avoid use of DAPZURA RT in pediatric patients younger than one year of age due to the risk of potential effects on muscular, neuromuscular, and/or nervous systems (either peripheral and/or central) observed in neonatal dogs [see Warnings and Precautions (5.7) and Nonclinical Toxicology (13.2)]. 

DAPZURA RT is not indicated in pediatric patients with renal impairment because dosage has not been established in these patients. 

DAPZURA RT has not been studied in pediatric patients with other bacterial infections. 

DAPZURA RT is contraindicated in adult and pediatric patients with HFI. Because a diagnosis of HFI may not yet be established in pediatric patients, obtain a careful history of HFI symptoms with sorbitol/fructose/sucrose exposure prior to administration of DAPZURA RT [see Warnings and Precautions (5.11)].
The utility model discloses a chrysanthemum processing machine which comprises a machine frame (1). A conveying belt (2) which penetrates through the left end and the right end is arranged on the machine frame (1). The conveying belt (2) is provided with a feeding section (3), a steam section (4) and a discharging section (5) from left to right in sequence. The steam section (4) is provided with a steam box (6) fixed on the machine frame (1). A steam inlet pipe (7) is arranged beside the machine frame (1). The steam inlet pipe (7) is connected with a lower steam pipe (8) which is fixed at the bottom of the steam box. An upward air outlet (9) is formed in a pipe body of the lower steam pipe (8). The steam inlet pipe (7) is connected with an upper steam pipe (10) which is fixed at the top of the steam box. A downward air outlet (9) is formed in a pipe body of the upper steam pipe (10). A fan (11) is arranged below the discharging section (5). A protecting net (12) is arranged right above the fan (11). An electric heating wire (21) is arranged on the inner surface of the steam box (6) in a paving mode. The working efficiency of chrysanthemum deactivation is greatly improved, steam deactivation can be carried out on the upper face and the lower face of a chrysanthemum, processing effect is good, and the chrysanthemum is dried by the fan after steam deactivation.
The invention discloses a traditional Chinese medicine pill of a pill for nourishing heart, tonifying qi and removing blood stasis, which is prepared from the following components in part by weight: the traditional Chinese medicine composition is prepared from 13 traditional Chinese medicines including American ginseng, raw astragalus, salvia miltiorrhiza, leech, ground beetle, coptis chinensis, asarum, sandalwood, radix ophiopogonis, schisandra chinensis, liquorice, plantain seed and couchgrass root. 1. Has no influence or little influence on normal physiological functions and no toxic or side effect. 2. The effect is nonspecific and broad-spectrum. 3. Has effects in regulating physiological function, nourishing yin, dredging collaterals, promoting blood circulation, removing blood stasis, invigorating qi, activating yang, activating qi-flowing, dredging collaterals, nourishing heart, replenishing kidney essence, nourishing heart blood, nourishing heart yin, eliminating turbid pathogen, protecting heart, improving blood flow of heart, regulating blood circulation, and enhancing physiological function of heart. 4. Can improve the clinical symptoms and physical signs of patients, regulate the blood circulation of bodies and enhance and improve the blood supply function of hearts.
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of obesity and, in severe cases, progresses to metabolic dysfunction-associated steatohepatitis (MASH). Small heterodimer partner (SHP) is an orphan member of the nuclear receptor superfamily and regulates metabolism and inflammation in the liver via a variety of pathways. In this study, we investigate the molecular foundation of MASH progression in mice with hepatic SHP deletion and explore possible therapeutic means to reduce MASH.
METHODS: Hepatic SHP knockout mice (SHPΔhep) and their wild-type littermates (SHPfl/fl) of both sexes were fed a fructose diet for 14 weeks and subjected to an oral glucose tolerance test. Then, plasma lipids were determined, and liver lipid metabolism and inflammation pathways were analyzed with immunoblotting, RNAseq, and qPCR assays. To explore possible therapeutic intersections of SHP and inflammatory pathways, SHPΔhep mice were reconstituted with bone marrow lacking interferon γ (IFNγ-/-) to suppress inflammation.
RESULTS: Hepatic deletion of SHP in mice fed a fructose diet decreased liver fat and increased proteins for fatty acid oxidation and liver lipid uptake, including UCP1, CPT1α, ACDAM, and SRBI. Despite lower liver fat, hepatic SHP deletion increased liver inflammatory F4/80+ cells and mRNA levels of inflammatory cytokines (IL-12, IL-6, Ccl2, and IFNγ) in both sexes and elevated endoplasmic reticulum stress markers of Cox2 and CHOP in female mice. Liver bulk RNAseq data showed upregulation of genes whose protein products regulate lipid transport, fatty acid oxidation, and inflammation in SHPΔhep mice. The increased inflammation and fibrosis in SHPΔhep mice were corrected with bone marrow-derived IFNγ-/- myeloid cell transplantation.
CONCLUSION: Hepatic deletion of SHP improves fatty liver but worsens hepatic inflammation possibly by driving excess fatty acid oxidation, which is corrected by deletion of IFNγ specifically in myeloid cells. This suggests that hepatic SHP limits fatty acid oxidation during fructose diet feeding but, in doing so, prevents pro-MASH pathways. The IFNγ-mediated inflammation in myeloid cells appears to be a potential therapeutic target to suppress MASH.
PROBLEM TO BE SOLVED: To obtain the subject absorbing barrier membrane, excellent in thermal stability, processability, reproducibility, storage stability, bioabsorptivity and agenesis, useful for reconstruction of tissues of animals including humans and usable for an anagenetic induction method. SOLUTION: This absorbing barrier membrane comprises a lactic acid-based polyester prepared by carrying out the inactivation treatment of a polymerization catalyst (e.g. tin octanoate, zinc chloride or an alkoxytitanium) with a chelating agent (e.g. ethylenediaminetetraacetic acid, oxalic acid or phosphoric acid) and/or acid phosphoric esters (e.g. an acid phosphoric ester or a phoshonic ester) as an essential ingredient and further a calcium phosphate (e.g. tricalcium phosphate or hydroxyapatite) and contains pores, having 0.1-200 μm diameter and present therein. The lactic acid-based pplyester contains a structural unit derived from lactic acid and a polyester structural unit with 2-60 wt.% content thereof derived from a dicarboxylic acid and a diol and has preferably 30,000-300,000 molecular weight.
Distribution

After inhalation, Technegas Aerosol is adsorbed on the walls of pulmonary bronchioles and alveoli. The distribution within the lungs is determined by the size and aerodynamic properties of the individual particles. Following inhalation, the particles are retained in the lung. The redistribution of Technegas Aerosol following inhalation to human subjects has been monitored for as long as 70 hours without evidence of particulate translocation.

Elimination   
There is no intravascular clearance, and the elimination of radioactivity occurs by the physical decay of the Technetium-99m. The Technegas Aerosol particles that are deposited in the mouth and along the mucociliary elevator are cleared by swallowing or expectoration. The particles that deposit in the alveolar region are cleared by alveolar macrophages.
This prospective case series will investigate the effects of the WDT on subjects with narrow anterior chamber angles on the day of their scheduled laser iridotomy. The angle configuration and IOP will be monitored following the WDT. Twenty patients with occludable angles will be enrolled in this study. After measuring the baseline IOP, weight and height, the patients will be asked to drink 10ml/kg water over 15 minutes (equal to approximately 0.33 ounces of water for every 2.2 pounds of weight or 2 ½ cups for a 150 lb. individual) and their IOP will be checked every 15 minutes up to one hour after drinking the water. This will be repeated after performing a laser iridotomy. The data obtained, mainly IOP and gonioscopic findings, will be analyzed using statistical tests and compared to historical controls of the WDT without narrow angles, and laser iridotomy subjects without the WDT.
Afamelanotide implants were administered on Days 0 and 60. Patients returned to the clinic on Day 120 for the final visit.
Alkylating agents have been found to have chemotherapeutic value in cancer treatment. The difficulty of altering the alkylation rate or specificity of alkylating agents is solved by methyl release from metallo N-methyl porphyrins in which the release rate is determined by the particular metal ion of the complex. Moreover, it has been shown that porphyrins accumulate specifically in tumors. Sodium aquo-N-methyltetra (p-sulfophenyl) porphinatocopper (II) trifluoromethanesulfonate has been shown to have activity against lymphocytic PS-P-388 (P388) leukemia in mammals. A wide range of N-substituents and metallo complexes, and their preparation are given. Anti-tumor use is demonstrated against P388 leukemia in animals.
Music is an important part of life for many people. It can evoke a wide range of emotions, including sadness, happiness, anger, tension, relief and excitement. People with hearing loss and people with cochlear implants have reduced abilities to discriminate some of the features of musical sounds that may be involved in evoking emotions. This paper reviews these changes in perceptual abilities and describes how they affect the perception of emotion in music. For people with acquired partial hearing loss, it appears that the perception of emotion in music is almost normal, whereas congenital partial hearing loss is associated with impaired perception of music emotion. For people with cochlear implants, the ability to discriminate changes in fundamental frequency (associated with perceived pitch) is much worse than normal and musical harmony is hardly perceived. As a result, people with cochlear implants appear to judge emotion in music primarily using tempo and rhythm cues, and this limits the range of emotions that can be judged. This article is part of the theme issue 'Sensing and feeling: an integrative approach to sensory processing and emotional experience'.