anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Provided is a method for extracting ceramide from rice bran, including steps (a) to (d). In step (a), a mixture containing the rice bran and ethanol is extracted and separated to obtain an extracting solution. In step (b), the extracting solution is concentrated to obtain a concentrated extracting solution containing a concentrated solution and a paste. In step (c), the paste in the concentrated extracting solution is removed, and the concentrated solution is extracted. In step (d), ethanol is added into the concentrated solution to form a mixed solution, the mixed solution is stood to generate layers and an upper layer including a supernate is extracted. By virtue of step (d) and step (c) that the paste in the concentrated extracting solution is removed, a high-purity ceramide can be extracted by using the method provided in this invention.
BACKGROUND: In recent years, active surveillance has been introduced as an alternative to excisional treatment in younger women with cervical intraepithelial neoplasia grade 2 because regression rates are high and excisional treatment is associated with increased risk of preterm birth. However, early identification of women at increased risk of persistence/progression is important to ensure timely treatment. Evidence is limited on biomarkers that may be used to identify women at increased risk of persistence/progression.
OBJECTIVE: This study aimed to describe human papillomavirus HPV type-specific persistence/progression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2.
STUDY DESIGN: We conducted a historical cohort study of women aged 23 to 40 years diagnosed with cervical intraepithelial neoplasia grade 2 at Aarhus University Hospital from 2000 to 2010. Women were identified through the Danish Pathology Data Bank (DPDB) and were considered as undergoing active surveillance if they had a first record of a cervical biopsy within 2 years after index diagnosis and no loop electrosurgical excision procedure before this. Human papillomavirus genotyping was performed on archived tissue samples using the HPV SPF10-DEIA-LiPA25 system (DNA ELISA [enzyme-linked immunosorbent assay] HPV SPF10 kit and RHA HPV SPF10-LiPA25 kit). Persistence/progression was defined as having a record of cervical intraepithelial neoplasia grade ≥2 in the DPDB determined on the last and worst diagnosis on a biopsy or loop electrosurgical excision procedure specimen during follow-up. We estimated the relative risk (95% confidence interval) of persistence/progression using a modified Poisson model.
RESULTS: A total of 455 women were included. Two-thirds were aged ≤30 years (73.8%) at index diagnosis, and nearly half had a high-grade index cytology (48.8%). Overall, 52.2% of all women had cervical intraepithelial neoplasia grade ≥2 during follow-up; 70.5% were human papillomavirus-16-positive and 29.5% were positive for other human papillomavirus types. Human papillomavirus-16 was associated with a significantly higher risk of persistence/progression (relative risk, 1.64; 95% confidence interval, 1.37-1.95) compared with non-human papillomavirus-16. The risk of persistence/progression was highest in human papillomavirus-16-positive women with a high-grade index cytology compared with human papillomavirus-16-positive women with a low-grade cytology (relative risk, 1.29; 95% confidence interval, 1.03-1.61), whereas no differences were observed across age groups.
CONCLUSION: The highest risk of persistence/progression was observed among human papillomavirus-16-positive women, particularly those with associated high-grade cytology. These findings suggest that early excisional treatment should be considered in this group of women.
Liver fibrosis is a reversible process that can be delayed or even reversed through appropriate intervention during its development. The protein RECK, encoded by the Reck gene, regulates matrix metalloproteinase (MMP) activity and plays a crucial role in extracellular matrix (ECM) degradation and remodeling. Reduced RECK expression is found in various fibrotic tissues. However, the impact of restoring RECK expression on the development and progression of liver fibrosis has not yet been determined. This study found that the restoration of RECK expression attenuated TGF-β1-induced hepatic stellate cell (HSC) activation and mitigated carbon tetrachloride (CCl4)-induced acute liver injury. In a mouse model of liver fibrosis induced by CCl4, restoration of RECK expression reduced the degree of fibrosis, collagen deposition, and level of oxidative stress. RECK competes with Nrf2 for binding to Keap1, resulting in a decrease in the degradation of Nrf2 by Keap1 and an increase in the accumulation of Nrf2 in the cytoplasm. Under oxidative stress conditions, Nrf2 can be translocated to the nucleus for expression, initiating an antioxidant stress response, furthermore, Nrf2 can also activate MMP-9 and degrade the over-deposited collagen, thereby achieving the effect of alleviating liver fibrosis. Our study reveals a novel mechanism by which restoration of RECK expression ameliorates liver fibrosis, providing a promising target for combating liver fibrosis.
The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75 NTR ) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75 NTR  which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75 NTR . Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75 NTR . These molecules antagonise p75 NTR -mediated cell death.
Cleft lip and palate, which affects 0.5-1.6 out of every 1000 live births, is the most prevalent congenital defect of the head and neck .

When the palatal shelves and the medial nasal process fail to fuse together between the fourth and eighth weeks of development, unilateral cleft lip and palate results . Lip muscles are disrupted and abnormally inserted to the columellar base on the non-cleft side and from the alar base on the cleft side. The nasal floor and alveolus on the cleft side may be deficient or absent. Several approaches, including quadrangular flaps, triangular flaps, and rotationadvancement procedures, were established in the middle of the twentieth century White Roll Vermilion Turn Down Flap (WRV flap) from the lateral lip element Making a symmetrical lip with a small scar and restoring the face's natural appearance and functional structure are the objectives of cleft lip repair . Over the past century, numerous surgical repair approaches have been developed The first known cleft-lip repair was a straight-line suture and a simple cut along the cleft borders, followed by a curved incision to lengthen the lip Drawbacks of straight-line restorations included vertical scar contracture and lip notching Tennison-triangular Randall's approach, which relies on mathematical calculations and lessens vertical lip contraction, is the most popular triangular technique, however the scar violates the philtrum.The Millard rotation-advancement approach was created to align the scar with the philtral column naturally occurring. The initial rotation-advancement technique underwent various variations. Vermilion notching and a scar along the philtral line can be noticed in Millard's repair. The Cupid's bow is distorted and the white roll up is pulled up by scar contracture. was employed by Mishra to modify Millard's technique to create the vermilion and white roll on the medial lip segment. If there is medial hypoplastic vermilion or partial medial vermilion loss, the Mishra procedure is also used Anthropometric Evaluation of surgical technique and comparison of cleft and non-cleft sides are two benefits of measuring surgical outcome .Farkas and colleagues, provided normative measurements of the lip and nose. Qualitative Assessment is subjective assessment and can analyze facial aesthetics and appearance impairment using scales, indices, scoring systems, and rankings. Both direct and indirect techniques can be used to perform anthropometric measurements and qualitative assessments. The most accurate anthropometric method is direct anthropometry, which is the gold standard but requires general anesthesia in young kids. Two dimensional (2D) images can be used for indirect anthropometry; however, calibration and image distance standardization are needed for linear measurements.
FIELD: veterinary science, pharmacy. SUBSTANCE: method involves mixing industrial oil with bioactive substances: pine galipot, beeswax or unrefined beeswax and chalk. Mixing is carried out in reactor at 100-105 C. Industrial oil is added to mixture by portions at temperature 85-80 C in reactor. The obtained mixture is filtered off for 10-15 min, then chalk is added, stirred in reactor for 30-40 min, cooled with water to 30 C. Components were taken at the following ratio, %: pine galipot 19-21; beeswax or unrefined beeswax 16.8-17.5; chalk 10.5-12.0, and fatty base (industrial oil) - the rest. Pine galipot is subjected for mechanical cleansing and heated to 60 C before its addition. The prepared ointment is used for treatment of mastitis, burns, eczema and tissue damage. EFFECT: improved method of preparing. 4 cl
Pre-treatment tumor biopsy followed by 3 cycles of PS-341 given by IV infusion. Each cycle will last 3 weeks. PS-341 will be given 2 times a week for 2 weeks followed by a 'rest' week with no drug. After the 3rd cycle, subjects can continue to receive another 3 cycles of the study drug if their disease has not worsened.
The invention provides an application of a compound FTY720 in preparing a detection marker for treating behavioral and motor abnormalities, which are caused by nerve impulse control disorder and dyskinesia, and the amino acid sequence of ATP13A2 is shown in SEQ No. 1. The invention also provides application of ATP13A2 abnormality to preparation of a biological detection marker for impulse control behavior and abnormal movement diseases, wherein the decrease of sphingomyelin and the increase of ceramide in blood are caused by the abnormality of ATP. The invention also provides application of a ceramide analog compound FTY720 or a sphingomyelinase inhibiting compound Fluoxetine in preparing a medicament for treating impulse control behavior and abnormal movement diseases. The invention provides a novel therapeutic drug for the diseases of abnormal behaviors and movement. And provides a theoretical basis for clinical research of abnormal behavior and movement diseases.
The present invention discloses a medicament compound for treating osteoporosis, which is prepared from 50 to 200 portions by weight of soybean isoflavone, 100 to 500 portions by weight of nanometer pearl powder and 10 to 100 portions by weight of vitamin D3. In addition, a plurality of traditional Chinese medicines comprising ophiopogon root, barbary wolfberry fruit, glossy privet fruit, tortoise plastron, turtle shell, deerhorn glue, dendrobium, polygonatum, common yan rhizome, largehead atractylodes rhizome, pilose asiabell root, ginseng, cornus and Chinese date can be added to the medicament. The medicament compound has the advantages of good calcium-repleshing effect and perfect functions. After menopause women take the medicament compound for 12 weeks, the density of bones is obviously enhanced to be close to the normal level. In addition. The medicament compound solves the problems of every section of health care of middle-aged people and old people on multiple aspects, such as woman climacteric delay, renal function improvement and the like, and thereby, the fundamental constitutional problem of osteoporosis is solved. In addition, the medicament compound has no toxic or side effect, is completely suitable for administration of middle-aged people and old people, and is particularly suitable for administration of women at the age of 40 to 65 years.
OBJECTIVES: High-frequency spinal cord stimulation (10-kHz SCS) has been shown to be an effective treatment for refractory low back pain and neck pain with and without limb pain in clinical trial and real-world studies. However, limited information is available in the literature on the type and frequency of programming parameters required to optimize pain relief.
MATERIALS AND METHODS: Retrospective trial and postimplant clinical and system device data were analyzed from consecutive patients with neck pain and low back pain, with and without limb pain, from a single clinical site, including both thoracic and cervical lead placement. Best bipole, stimulation parameters, and outcomes, including pain relief, change in opioid medication use, sleep, and daily function, were analyzed.
RESULTS: Of the 92 patients in the trial, 70 received a permanent implant. Of these, the mean duration of follow-up was 1.8 ± 1.3 years. Pain relief of ≥50% at the last follow-up was achieved by 64% of patients implanted; in addition, 65% reduced their opioid medication use; 65% reported improved sleep, and 71% reported improved function. There was some consistency between the "best" bipole at trial and permanent implant, with 82% of patients within one bipole location, including 54% of permanent implants who were using the same best bipole as at trial. After permanent implant, device reprogramming was minimal, with ≤one reprogramming change per patient per quarter required to maintain pain outcomes.
CONCLUSIONS: In the study, 10-kHz SCS was an effective therapy for treating chronic pain, whereby a high responder rate (≥50% pain relief) was achieved with short time to pain relief in trial and maintained with limited device programming after permanent implant. The data presented here provide insight into the programming required during the trial and implant stages to obtain and maintain therapeutic efficacy.
This app is designed to be a cognitive training game that conditions the CCN. This is done by having participants play a multitasking game that targets their perceptual discrimination abilities, selective attention, and visuomotor tracking skills. At the first session, participants will be directed to an initial assessment of each of these cognitive control skills in a single task and dual-task setting (a total of 3 different diagnostics, described below). Each week, this diagnostic phase will reflect the training paradigm they will encounter for that week, as each week the perceptual and tracking challenges will increase.
Sitagliptin, 50 mg, once daily for 12 weeks, orally. Due to interim analysis of this study and another Phase IIB study, participants in this arm were switched into the 100-mg once daily arm during either the first or initiation of the second extensions study periods.
Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.
The present invention relates to a pharmaceutical composition and health-aid food for preventing or treating/alleviating diabetes mellitus including, as an active ingredient, mixed extract of vegetable natural products having excellent effects of removing swelling, enhancing level of immunity and enhancing metabolism. Particularly, the present invention relates to a pharmaceutical composition and health-aid food for preventing or treating/alleviating diabetes mellitus through activity of inhibiting beta-amylase and alpha-glucosidase. The pharmaceutical composition and health-aid food comprise, as an active ingredient, hydrothermal extract of a mixture of vegetable natural products, including water parsley, burdock, pumpkin, plantain leaves, adzuki beans, black beans, jujube and ginger, or ethanol extract obtained additionally from the same. As demonstrated by the examples of the disclosure, the mixed extract of vegetable natural products, including water parsley, burdock, pumpkin, plantain leaves, adzuki beans, black beans, jujube and ginger, used as an active ingredient of the anti-diabetic composition has a significantly high total polyphenol content and total flavonoid content, while showing a significantly low total sugar and reduced sugar content, shows anti-diabetic activity through activity of inhibiting beta-amylase and alpha-glucosidase. In addition, the active ingredient causes no hemolytic activity to the human red blood cells, has excellent thermal stability, and causes no loss of activity of beta-amylase and alpha-glucosidase even under an acidic condition of pH 2 and in the blood plasma. Thus, the active ingredient can be prepared in various forms, such as extract, powder, pills and tablets, which can be administered at all times. Thus, the present invention is very useful in the field of pharmaceuticals and foods.
Ductal carcinoma in situ (DCIS) is a heterogeneous breast disease that remains challenging to treat due to its unpredictable progression to invasive breast cancer (IBC). Contemporary literature has become increasingly focused on extracellular matrix (ECM) alterations with breast cancer progression. However, the spatial regulation of the ECM proteome in DCIS has yet to be investigated in relation to IBC. We hypothesized that DCIS and IBC present distinct ECM proteomes that could discriminate between these pathologies. Tissue sections of pure DCIS, mixed DCIS-IBC, or pure IBC (n = 22) with detailed pathological annotations were investigated by multiplexed spatial proteomics. Across tissues, 1,005 ECM peptides were detected in pathologically annotated regions and their surrounding extracellular microenvironments. A comparison of DCIS to IBC pathologies demonstrated 43 significantly altered ECM peptides. Notably, eight fibrillar collagen peptides could distinguish with high specificity and sensitivity between DCIS and IBC. Lesion-targeted proteomic imaging revealed heterogeneity of the ECM proteome surrounding individual DCIS lesions. Multiplexed spatial proteomics reported an invasive cancer field effect, in which DCIS lesions in closer proximity to IBC shared a more similar ECM profile to IBC than distal counterparts. Defining the ECM proteomic microenvironment provides novel molecular insights relating to DCIS and IBC.
Total knee arthroplasty (TKA) is a surgical procedure used to restore painless joint function and increase patients' activities of daily living in patients with progressive knee osteoarthrosis. Kinesiophobia can be seen in patients suffering from pain. It is stated that the incidence of kinesiophobia in TKA patients is 24.4%. Pain etc. While conditions can be relieved by pharmacological treatment methods, non-pharmacological treatments can be effective in relieving patients' pain. With the relief of pain, it will be possible to eliminate the kinesiophobia experienced by the patients. It is known that humor, which is among the non-pharmacological treatment methods, increases the pain resistance of the patients, reduces the stress hormone, and strengthens the immune system. It is reported in the literature that listening to music, another non-pharmacological treatment, is also effective in relieving pain after TKA. For this reason, the study was planned to determine the effect of postoperative music and comedy films on kinesiophobia and pain in patients undergoing TKA.
An exemplary nasal inhaler band is fitted on the upper lip below the nasal openings of a user. The device provides minimal restriction of ambient airflow into the nostrils during inhalation, while also providing a flow of beneficial vapors into such airflow. A main body of the device has an outer layer adapted to hold vapor-releasing solids, liquids or gels. The outer layer is air-permeable and absorbent. The main body also has a base layer contacting the upper lip. The base layer is impermeable, so that volatile solids, liquids or gels do not come into contact with the user's skin. The main body is held in position in contact with the nose and upper lip by elastic straps extending back from ends of the main body to wrap around the user's ears.
An acid-sensitive polypeptide liposome, a preparation method and application thereof in mRNA drug delivery, belonging to the technical field of drug carriers. The acid-sensitive polypeptide liposome is obtained by modifying a pegylated liposome through targeted pH-sensitive polypeptide by virtue of acid-sensitive chemical bond connection. The targeted pH-sensitive polypeptide is a fragment of a polypeptide which is modified by RGD cyclopeptide at the C-terminal, and the polypeptide comprises TAT, H7R8 or AibCys. The invention also provides an anti-tumor drug complex comprising the acid-sensitive polypeptide liposome and the mRNA anti-tumor drug wrapped by the acid-sensitive polypeptide liposome. The targeted pH-sensitive polypeptide liposome provided by the invention can realize electrostatic coating of medicaments such as mRNA (messenger ribonucleic acid) and the like, and further realize intracellular targeted transportation of the medicaments such as mRNA and the like. The targeted pH sensitive polypeptide liposome is utilized to transport medicaments such as mRNA and the like to realize the treatment of cancer, and the cell uptake of tumor cells to the liposome is enhanced.