anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A Vigna nakashimae-derived compound and a composition containing the same are provided to strongly prevent enzyme activation and to prevent or treat alpha-glucosidase related diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating alpha-glucosidase related diseases contains a compound of chemical formulas 1-3 as an active ingredient. The diseases are diabetic disease or obesity. The composition additionally contains pharmaceutically acceptable carriers. A food composition for preventing or treating the diseases contains the compound of chemical formula 1-3 as an active ingredient. A method for preparing the extract comprises: a step of extracting Vigna nakashimae with low carbon number alcohol of C1-C4, water, or a mixture solvent thereof; a step of fractioning the extract with ethanol, chloroform, methanol, or water; and a step of performing the fraction by column chromatography.
Cosmetic and pharmaceutical compsns. contg. a  vitamin A ester (I), and an aq. emulsion of hydrogen peroxide, are new. USE/ADVANTAGE - Treatment of burns, wounds, ulcers, -haemorrhoids, aging of the  skin, and acne. The compsns. also have a disinfectant action. The presence of the peroxide increases the known action of the vitamin A, but by using it in emulsion form, there are no undesirable side -effects.
BACKGROUND: The aim of this study was to determine whether the use of indocyanine green angiography to identify devascularized parathyroids during thyroidectomy for thyroid cancer would decrease the rates of postoperative hypoparathyroidism.
METHODS: Retrospective study of patients who had undergone total thyroidectomy for treatment of thyroid cancer between March 2021 and March 2023. The indocyanine group included patients with all four parathyroids identified and evaluated by indocyanine green angiography at the end of the procedure. Those with parathyroid glands classified with no vascularization had the glands autotransplanted. A group without indocyanine angiography was used to compare results.
RESULTS: The analysis included 100 patients in each group. Indocyanine angiography identified 14.75% of devascularized parathyroids at surgery. The number of parathyroids with a score of 2 (i.e., good vascularization) was not a safe predictor of normal parathyroid hormone levels after surgery. Indeed, 29.2% of the patients with three parathyroids with a score of 2 developed transient hypoparathyroidism. Permanent hypoparathyroidism occurred in 7% of the patients without indocyanine group and in none of the patients in the indocyanine group (p = 0.014).
CONCLUSION: Intraoperative angiography with indocyanine green could contribute to reduce the occurrence of permanent hypoparathyroidism in patients undergoing surgical treatment for thyroid cancer.
The mechanisms of hepatic stellate cell (HSC) activation and the development of liver fibrosis are not fully understood. Here, we show that deletion of a nuclear seven transmembrane protein, TM7SF3, accelerates HSC activation in liver organoids, primary human HSCs, and in vivo in metabolic-dysfunction-associated steatohepatitis (MASH) mice, leading to activation of the fibrogenic program and HSC proliferation. Thus, TM7SF3 knockdown promotes alternative splicing of the Hippo pathway transcription factor, TEAD1, by inhibiting the splicing factor heterogeneous nuclear ribonucleoprotein U (hnRNPU). This results in the exclusion of the inhibitory exon 5, generating a more active form of TEAD1 and triggering HSC activation. Furthermore, inhibiting TEAD1 alternative splicing with a specific antisense oligomer (ASO) deactivates HSCs in vitro and reduces MASH diet-induced liver fibrosis. In conclusion, by inhibiting TEAD1 alternative splicing, TM7SF3 plays a pivotal role in mitigating HSC activation and the progression of MASH-related fibrosis.
A subset of patients with post-COVID-19 condition (PCC) fulfill the clinical criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To establish the diagnosis of ME/CFS for clinical and research purposes, comprehensive scores have to be evaluated. We developed the Munich Berlin Symptom Questionnaires (MBSQs) and supplementary scoring sheets (SSSs) to allow for a rapid evaluation of common ME/CFS case definitions. The MBSQs were applied to young patients with chronic fatigue and post-exertional malaise (PEM) who presented to the MRI Chronic Fatigue Center for Young People (MCFC). Trials were retrospectively registered (NCT05778006, NCT05638724). Using the MBSQs and SSSs, we report on ten patients aged 11 to 25 years diagnosed with ME/CFS after asymptomatic SARS-CoV-2 infection or mild to moderate COVID-19. Results from their MBSQs and from well-established patient-reported outcome measures indicated severe impairments of daily activities and health-related quality of life.    Conclusions: ME/CFS can follow SARS-CoV-2 infection in patients younger than 18 years, rendering structured diagnostic approaches most relevant for pediatric PCC clinics. The MBSQs and SSSs represent novel diagnostic tools that can facilitate the diagnosis of ME/CFS in children, adolescents, and adults with PCC and other post-infection or post-vaccination syndromes. What is Known: • ME/CFS is a debilitating disease with increasing prevalence due to COVID-19. For diagnosis, a differential diagnostic workup is required, including the evaluation of clinical ME/CFS criteria. • ME/CFS after COVID-19 has been reported in adults but not in pediatric patients younger than 19 years. What is New: • We present the novel Munich Berlin Symptom Questionnaires (MBSQs) as diagnostic tools to assess common ME/CFS case definitions in pediatric and adult patients with post-COVID-19 condition and beyond. • Using the MBSQs, we diagnosed ten patients aged 11 to 25 years with ME/CFS after asymptomatic SARS-CoV-2 infection or mild to moderate COVID-19.
Sepsis is a complex condition of inflammatory and immune dysregulation, triggered by severe infection. In survivors, chronic inflammation and immune dysregulation linger, facilitating the emergence of infections. CD8 dysfunction contributes to immunosuppression in sepsis survivors. We devised an animal model that enabled us to identify and analyze CD8-intrinsic defects induced by sepsis. We adoptively transferred CD45.1 CD8 OT-I T cells into CD45.2 congenic mice and subjected them to cecal ligature and puncture, to induce abdominal sepsis. One month later, we isolated the transferred CD8 cells. Surface marker expression confirmed they had not been activated through the TCR. CD8 OT-I T cells isolated from septic (or sham-operated) mice were transferred to second recipients, which were challenged with OVA-expressing Listeria monocytogenes. We compared effector capacities between OT-I cells exposed to sepsis and control cells. Naive mice that received OT-I cells exposed to sepsis had higher bacterial burden and a shorter survival when challenged with OVA-expressing L. monocytogenes. OT-I cells isolated from septic mice produced less IFN-γ but had conserved activation, expansion potential, and cytotoxic function. We observed lower transcript levels of IFN-γ and of the long noncoding RNA Ifng-as1, a local regulator of the epigenetic landscape, in cells exposed to sepsis. Accordingly, local abundance of a histone modification characteristic of active promoter regions was reduced in sepsis-exposed CD8 T cells. Our results identify a mechanism through which inflammation in the context of sepsis affects CD8 T cell function intrinsically.
BACKGROUND: Hospital-acquired pneumonia (HAP) and its specific subset, non-ventilator hospital-acquired pneumonia (nvHAP) are significant contributors to patient morbidity and mortality. Automated surveillance systems for these healthcare-associated infections have emerged as a potentially beneficial replacement for manual surveillance. This systematic review aims to synthesise the existing literature on the characteristics and performance of automated nvHAP and HAP surveillance systems.
METHODS: We conducted a systematic search of publications describing automated surveillance of nvHAP and HAP. Our inclusion criteria covered articles that described fully and semi-automated systems without limitations on patient demographics or healthcare settings. We detailed the algorithms in each study and reported the performance characteristics of automated systems that were validated against specific reference methods. Two published metrics were employed to assess the quality of the included studies.
RESULTS: Our review identified 12 eligible studies that collectively describe 24 distinct candidate definitions, 23 for fully automated systems and one for a semi-automated system. These systems were employed exclusively in high-income countries and the majority were published after 2018. The algorithms commonly included radiology, leukocyte counts, temperature, antibiotic administration, and microbiology results. Validated surveillance systems' performance varied, with sensitivities for fully automated systems ranging from 40 to 99%, specificities from 58 and 98%, and positive predictive values from 8 to 71%. Validation was often carried out on small, pre-selected patient populations.
CONCLUSIONS: Recent years have seen a steep increase in publications on automated surveillance systems for nvHAP and HAP, which increase efficiency and reduce manual workload. However, the performance of fully automated surveillance remains moderate when compared to manual surveillance. The considerable heterogeneity in candidate surveillance definitions and reference standards, as well as validation on small or pre-selected samples, limits the generalisability of the findings. Further research, involving larger and broader patient populations is required to better understand the performance and applicability of automated nvHAP surveillance.
Participants will be fit with hearing aids using two different fitting methods (fitting A and fitting B). The order of the fitting will be randomized such that half of the participants will start out with fitting A and half of the participants will start out with fitting B. All participants will undergo baseline speech testing and answer a questionnaire about their experiences in daily life without hearing aids. All participants will use devices for a period of 1-2 weeks in their daily lives. After this first home trial, participants will return to the clinic where they will answer questionnaires regarding their experience with the devices. They will also perform aided speech testing. They will then be given devices with the second fitting method and will wear devices for a period of 1-2 weeks in their daily lives. Following the second home trial, all participants will return to the clinic to answer the same questionnaire that was given after home trial #1, and complete aided speech testing. The results for each of the two fitting methods will be analyzed.
The invention discloses a drug for treating flat wart. The drug for treating flat wart comprises folium mori, wild chrysanthemum, mongolian dandelion herb, roots of indigowoad, portulaca oleracea, rhizoma smilacis glabrae, roots of common peony, safflower and coix seeds which are evenly mixed and smashed to be a 200-mesh powder, the 200-mesh powder is divided into sixty pouches, 3g of the powder is loaded in each pouch, or the powder is loaded into capsules. The use method is as follows: three times per day, one pouch each time, and plain water for taking. The flat wart can generally be cured by taking the drug for 2 to 3 courses of the treatment. The drug provided by the invention has the treating effects of dispelling wind and calming the liver, clearing away heat and toxic materials, promoting blood circulation and playing an effect of heavy material therapy, is quick in treating flat wart, and has a good curative effect. The total effective rate can reach 98.2 percent.
Brentuximab vedotin is an antibody-drug conjugate (ADC) composed of the anti-CD30 chimeric immunoglobulin G1 (IgG1) monoclonal antibody cAC10 and the potent antimicrotubule drug monomethyl auristatin E connected by a protease-cleavable linker. cAC10 binds to the CD30 antigen, which has a very low expression on normal cells but is found on some tumor cells.
PURPOSE: To prepare the subject aqueous solution useful for topical application in ophthalmology by dissolving an active ingredient in pure water while cold, preparing a solution at a regulated pH and mixing the resultant solution with a solution containing a preservative dissolved therein. CONSTITUTION: (A) Lysine α-methyl-4-(2'-thienylcarbonyl)phenylacetate is dissolved in pure water while cold and an isotonizing agent, as necessary, is added thereto. The pH thereof is subsequently regulated to 6-18 while adding a buffer substance based on a phosphate or boric acid/sodium borate, as necessary, thereto under stirring and the volume thereof is regulated with pure water. The resultant solution is then sterilely filtered. (B) A preservative is dissolved in pure water (while cold in the case of thiomersal and under heating at 90-95 deg.C in the case of methyl p-hydroxybenzoate) and the volume thereof is regulated with pure water. The resultant solution is further sterilely filtered and a hydrophilic polymer or an isotonizing agent or both, as necessary, are added thereto.  (C) Both the solutions A and B are mixed and filled in a flask for immediate use or (D) the solution B is filled in the flask and the solution A is freeze-dried so as to enable the direct preparation in use.
Hepatic imaging plays an important role in identifying and differentiating both benign and malignant neoplasms of the liver. One of the clinical and radiologic dilemmas facing hepatic medicine is the accurate differentiation of focal nodular hyperplasia (FNH) and hepatic adenoma (HA). This is a question of some import, as there are significant prognosis and treatment differences between these entities, as well as overlap in the patient populations in whom they occur.

FNH is the second most common benign neoplasm of the liver, with a strong female predilection. These lesions are usually asymptomatic and incidentally discovered, and carry only a small risk of complication such as bleeding. There is no malignant potential. Hepatic adenomas (HAs) are more rare benign neoplasms that also have a female predilection. However, these lesions are more likely to be symptomatic, and carry a higher bleeding risk especially as they grow over 4 cm. In addition, they harbor a small risk of malignant transformation to hepatocellular carcinoma (HCC). Of note, patients may present with both types of lesion concurrently.

Currently, MRI with hepatobiliary contrast agents is the standard for differentiation of these lesions. These agents (such as gadoxetate disodium, or Eovist) are actively transported into hepatocytes, which are present in FNH and only in very rare cases with HA. Previous research (such as from Grazioli et al.) has shown that hepatobiliary agents can differentiate these lesions with excellent accuracy. However, there is still overlap between these lesions on imaging, and for certain patients MRI may be difficult or impossible.

FDA approval of contrast enhanced ultrasound (CEUS) agents in 2016 has opened a new avenue for abdominal imaging. CEUS utilizes gas containing lipid microbubbles to provide pure intravascular contrast, allowing for evaluation of vascular and solid organ perfusion. It has an excellent safety profile and is not excreted by the kidneys, allowing for use in patients with acute and chronic renal disease. It has been used for some time outside of the US for liver lesion evaluation, and the enhancement patterns of both FNH and HA have been described in the literature by Kim et al. as having different appearances. CEUS can be especially useful for focal liver lesion imaging for patients who cannot or will not undergo MRI, and it has the advantages of flexibility, increased temporal resolution, and decreased cost. This study aims to compare the utility of CEUS for differentiating FNH and HA with the current standard of hepatobiliary contrast MRI.
PROBLEM TO BE SOLVED: To obtain cosmetics for skin, consisting essentially of a specific cholesterol ester and vitamin E (derivative) and having improving activities of an aged skin such as improving activities on a roughened skin, advancing activities of water-retaining function and activities for making the skin beautiful. SOLUTION: The objective cosmetics consist essentially of (A) a cholesterol ester of an iso form and/or anti-iso form fatty acid of formulas I [(n) is 6-32] and II, and (B) vitamin E and/or vitamin E derivative (e.g. an acetate). The iso form and/or anti-iso form fatty acid derived from a mammal lanolin or vernix caseosa can be used as the iso form and/or anti-iso form fatty acid. The formulating amount of the component A is preferably 0.01-50wt.% and that of the component B is preferably 0.001-10.0wt.% based on the whole amount of the final preparation. The formulation ratio of the components A to B is preferably (0.01:1) to (100:1). The cosmetics can optionally includes sphingolipids, phospholipids, sterols and steroids other than the essential component.
LT has evolved rapidly, becoming the standard therapy for acute and chronic liver failure of a variety of aetiologies, with more than 80,000 procedures performed to date \[13\]. HBV infection is a worldwide public health problem, especially in China. The need for an antiviral treatment with NAs for liver transplant recipients has two objectives: the improvement of liver function and to decrease the risk of HBV recurrence after transplant. TAF, TDF and ETV are currently the first-line therapy in patients with CHB in all CHB treatment guidelines, which have a greater potency and higher barriers to resistance. TAF treatment for HBV prophylaxis could lead to significant reduction in ALT and significant improvement in renal function. However, data are scarce regarding to TAF monotherapy without HBIG for HBV prophylaxis in post orthotopic liver transplant with HBV-related disease. This study is based on a real-world, multi-center, prospective study to assess the effectiveness and safety of TAF for HBV prophylaxis, which will fill in gaps with TAF monotherapy without HBIG in post liver transplant.
The cRCT will be comprised of three cohorts of matched pairs representing approximately 40 diverse sites (12-15 pairs of hospitals hospitals and 5-7 pairs of clinics/practices) to determine whether SFA for frontline HCWs improves mental and physical well-being compared to Usual Care (UC). Each pair will be assigned to either SFA or UC using a simple 1:1 randomization. SFA sites will implement SFA through a "train-the-trainer" model.
During World War II, the population of agricultural areas of Slavonia and Srijem lived in privation, but there was no famine. A more serious threat was infectious diseases, such as malaria, typhoid fever, and dysentery, which were also present within the population in the post-war period. Major epidemics broke out mostly in areas under partisan control, especially in the areas of western and central Slavonia, where major epidemic typhus contagious broke out. Venereal diseases, less common in the Slavonian area before the war, were also on the rise. Two factors had an impact on the health situation within the population – state medical institutions and partisan medical corps. Health care and measures to combat infectious diseases were provided by state authorities, and that is still an insufficiently explored area in historiography. During the first years of the war, the partisan medical corps personnel, initially mostly semiskilled and lacking necessary medical equipment and medications, relied on the support from the population to a greater extent than they were able to provide medical care to them. With the arrival of professional staff and the acquisition of medicines and medical equipment, mainly sourced from medical institutions in areas under partisan control, they assumed a more active role in supporting civilian authorities under the "people's rule"—specifically, the people's liberation committees. Their focus shifted to healthcare for the civilian population, primarily aimed at suppressing and preventing infectious diseases. Further research on this topic will contribute to a more realistic perception of the civilian population's everyday life during the war, which was presented in memoir literature and historiography of the socialist period as a heroic act of resistance rather than a struggle for survival in the conditions of privation and diseases; it will also complete the picture of the human losses of the civilian population caused by infectious diseases.
The present invention provides a nano-targeting drug loaded micelle. The nano-targeting drug loaded micelle has a core-shell structure; the core is IR780 iodide and the shell is hyaluronic acid; and the IR780 iodide and hyaluronic acid are connected by disulfide bonds. The nano-targeting drug loaded micelle has good water-solubility, biocompatibility and tumor cell targeting. The invention also provides a preparation method of the nano-targeting drug loaded micelle. The preparation method has mild conditions, and is simple convenient for industrialization production. The present invention also provides an anticancer medicament, including the nano-targeting drug loaded micelle and a hydrophobic drug. The nano-targeting drug loaded micelle includes IR780 iodide and hyaluronic acid. The anti-cancer medicament has a core-shell structure; the IR780 iodide and the hydrophobic drug formed a core; hyaluronic acid wraps on the surface of the core to form a shell; and the IR780 iodide and hyaluronic acid are connected by disulfide bonds. The anticancer medicament has good water-solubility, biocompatibility and tumor cell targeting. The invention also provides a preparation method of the anticancer medicament.
The invention relates to the field of immunology, in particular to a preparation method of a recombinant antigen for detecting chronic interstitial nephritis. The invention provides a method for producing beta 2-microglobulin by high-efficiency fermentation by using recombinant pichia pastoris. Compared with a recombinant escherichia coli expression system, the invention solves the problems of easy formation of inclusion bodies, difficult renaturation, easy loss of immunological activity and the like. Methanol is used as an induced carbon source to promote the expression of the AOX1 gene, thereby improving the expression quantity of the target protein. The content of the fermentation liquid nitrogen source is increased, urea is added and supplemented in batches by adopting a constant flow, peptone is supplemented in batches, and the optimal pH value is controlled by using ammonia water, so that the proper carbon nitrogen ratio is maintained, and the required substances are provided for the synthesis of target products. The invention shortens the induction time and improves the feed supplement rate, so that the degradation condition of the exogenous protein is improved, and the expression quantity of the same induction time is improved. The method has the advantages of good result correlation, high accuracy, simple operation and wide clinical application, and can accurately represent the change of the antigen concentration.