anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
One hundred patients suffering from recurrent implantation failure in intracytoplasmic sperm injection (ICSI) were included in the study. The patients were randomly allocated into two groups. The intervention group consisted of 50 patients who received intrauterine injected with granulocyte colony-stimulating factor (G-CSF). The other group (the control group) consisted of 50 patients and injected with intrauterine Human Chorionic Gonadotropins (HCG). Both groups received the interventions at ovum pick-up day. The main outcome was the clinical pregnancy rate which has been evaluated after 2 weeks of the positive pregnancy test. The secondary outcome was an ultrasound image of the gestational sac after 6 weeks of pregnancy.
The invention discloses an application of berberine in preparing a drug for treating sterility of ovulation disturbance. Studies show that berberine can promote ovulation of a patient suffering from infertility of ovulation disturbance; and during a treatment process, the probability of twins and triplets is far lower than that of an ovulation induction drug of clomiphene, thereby greatly reducing risks of multiple pregnancy and occurrence of pregnancy complications, and reducing occurrence of adverse reactions. Besides, the drug is cheap and can be accepted by the patient easily. The drug is attractive in price and quality and is worth of popularization and application. Therefore, the application of berberine in preparing the drug for treating the sterility of ovulation disturbance is provided by the invention. The novel curative effect becomes a novel indication of berberine, broadens clinical application capacity of berberine, and will achieve enormous social benefits and economic benefits.
Peri-implant infections (mucositis and peri-implantitis) depict an increasing focus in dental practice and implantology. mean prevalence of mucositis is of 43% and periimplantitis of 22%. Consequences for the implant without successful treatment range from local reversible inflammation (mucositis) to implant loss (periimplantitis). These lead to functional, social and esthetic prejudices for patients. The main factor for establishment of peri-implant infections is the formation and maturation of the bacterial biofilm. Peri-implantitis and mucositis treatment require the removal of the bacterial biofilm and the disinfection of the implant surface. Because of special surface conditions and structures, it is more difficult to remove bacterial biofilms from implant surfaces than teeth. the key to controlling the inflammation due to the bacterial biofilm is to prevent its installation and progression. The procedure tested in this study is an air abrasion device, the Air-Flow Master Piezon® with erythritol and chlorhexidine powders on implants presenting clinical and radiographic signs of mucositis and peri-implantitis along with renewal of local oral hygiene instructions in order to reduce the inflammation locally by disorganizing and eliminating the biofilm. Follow-up of the patients will be held every 2 months for 6 months by scoring the bleeding on probing, the plaque index and measuring clinical attachment level in order to compare it with the initial measure. At 6 month an X-ray will also enable to compare bone level and mineralization. This initial study will help establish a standardized protocol for peri-implant infection management.
Patients and their partners attend 6 weekly ACT sessions over 60-75 minutes. Couples learn skills of acceptance, avoidance, awareness, values and committed action, mindfulness and values in relationships, and handling persistent worries and concerns. Patients and their partners also do homework assignment after each session.
Among persons aged 55-84 years, over 65% have one to three common medical conditions (e.g., hypertension, diabetes, arthritis, stroke, heart disease, etc.). Fortunately, large randomized clinical trials have demonstrated the effectiveness of treatment and prevention strategies for many chronic conditions (e.g., dietary modification and medications for hypertension, intensive glucose monitoring with diet and medication regimens for diabetes, etc.). Despite the significant findings from numerous clinical trials, most older persons continue to suffer from uncontrolled hypertension, hyperglycemia, and other predictors of poor health outcomes. Non-compliance with clinical guidelines by providers (i.e. clinical inertia) and non-adherence to doctors' recommendations are typically blamed for these unacceptably poor outcomes. For older adults with several conditions, the processes of patient-clinician collaboration are not well understood. Goal-setting behaviors may improve health care by linking desired outcomes (i.e., reduce risk of heart attacks) to the goals of care (i.e., salt restriction for hypertension control). Furthermore, the process of goal-setting may be more effective if patients internalize the importance of a particular goal and prioritize that goal among multiple clinical problems (i.e., hypertension care for patients with diabetes.

Effective methods of implementing collaborative goals and training patients to negotiate shared goals and goal-directed behaviors with their clinicians have been developed for diabetes control. The effectiveness of these methods may be enhanced through the use of clinics that enroll small groups of subjects with rapid follow-up for several weeks. Group clinics have demonstrated improved outcomes for common chronic conditions. Evidence demonstrating the synergistic benefit of efficient group clinics and collaborative goal-setting is limited. However, an approach combining these methodologies may provide an improved method of rapidly controlling multiple chronic conditions and maintaining control of those chronic conditions over a prolonged time period.

To address the gap in the implementation of effective and efficient medical care, we will develop and test a model of collaborative group clinics that empowers older patients to adopt goal-setting behaviors, increases communication with their health care provider, and improves their diabetes-related outcomes. The objectives are to use a collaborative group clinic to: 1) Improve diabetes process of care outcomes over a 3 month time period; 2) Significantly improve the maintenance of diabetes process of care improvements over a 12 month time period; and 3) Significantly improve use of self-management behaviors for diabetes care.
PROBLEM TO BE SOLVED: To obtain an estrogen receptor gene, and the like, which can be used in a test system for evaluating the estrogen receptor activity-adjusting ability of a chemical substance. SOLUTION: This estrogen receptor gene is characterized by having a base sequence encoding either of the following amino acid sequences, and the like. (a) A specific amino acid sequence originated from Cnemidophorus uniparens. (b) An amino acid sequence which has >=85% sequence sameness as the above- described amino acid sequence and has an estrogen receptor activity. (c) An amino acid sequence encoding a specific base sequence originated from the above-described Cnemidophorus uniparens. (d) An amino acid sequence encoded in a base sequence having a >=85% sequence sameness as the above-described base sequence and having an estrogen receptor activity.
BACKGROUND: Robot-assisted total knee arthroplasty (RA-TKA) has significantly improved knee surgery outcomes in the last few years. However, its association with the periprosthetic joint infection (PJI) rate remains debatable. This study investigates the incidence of early and delayed PJI in a multicentric cohort of patients who underwent RA-TKA, aiming to elucidate the risk associated with this procedure.
METHODS: This retrospective study analyzed data from a consecutive series of patients who underwent RA-TKA using the NAVIO Surgical System (Smith & Nephew, Memphis, USA) between 2020 and 2023. The inclusion criteria encompassed individuals over 18 years of age with a minimum follow-up period of three months. The primary outcome was the incidence of early and delayed PJI, defined according to the European Bone and Joint Infection Society (EBJIS) diagnostic criteria. Secondary outcomes included the evaluation of postoperative complications.
RESULTS: The study included patients who underwent RA-TKA with the NAVIO system, achieving an average follow-up of 9.1 ± 3.9 months. None of the patients met the EBJIS criteria for a likely or confirmed infection, indicating an absence of both early and delayed PJI cases. Two patients required subsequent surgical interventions due to patellar maltracking and prosthetic loosening, respectively. Additionally, three patients underwent passive manipulation under anesthesia (MUA).
CONCLUSION: The findings indicate no evidence of early or delayed PJI in patients undergoing RA-TKA within the study period. The low complication rate further supports the reliability and safety of this surgical technique in short-term follow-up.
LEVEL OF EVIDENCE: IV.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: claimed invention relates to chemical-pharmaceutical industry, and can be applied in technology of pill production. After granulation in pseudoliquefied layer in dispersion carried out is calibration of granulated material on vertical conical calibrator with following process parametres: rotor speed - 2-5 rot/sec; gap between grid and rotor - 1-3 mm; diametre of grid cell - 1-2 mm. Active pharmaceutical substance is selected from group, which includes enalapril, captopril, methionine. Binding agent is selected from group, which includes polyvinylpyrrolydone, methylcellulose, gelatin, starch, copolymer of vinylpyrrolydone with vinylacetate, sucrose, vegetable extracts. ^ EFFECT: method of obtaining pills makes it possible to increase dosing accuracy by prevention of stratification of multi-component pilled masses, due to improvement of components and their mixtures friability and ensuring evenness of their supply to matrix of pill machine. ^ 7 cl, 3 ex, 12 tbl
ABSTRACT OF THE DISCLOSURE The present invention is directed to a diltiazem for-mulation suitable for one a day administration. The for-mulation contains a blend of diltiazem beads having two differing dissolution profiles. One type of bead is a rapid release bead which releases up to 100% of the dil-tiazem it contains within approximately 6 to 8 hours of administration. The second bead is a delayed release diltiazem bead and substantial quantities of diltiazem are not released from this bead until approximately 12 hours after administration with the majority of the dil-tiazem being released at 16 to 24 hours after administra-tion. The diltiazem formulation will typically contain from 25% to 60% w/w of the rapid release beads and from 40% to 75% w/w of the delayed release beads. Both the rapid release and the delayed release beads are made up of two parts, one being a central core containing the diltiazem while the other is a polymeric coating which envelops the central core.
Participants will read a short story and then watch moving images for 30 minutes or until any of their persisting concussion symptoms arise. The number and severity of symptoms will be assessed by completing SCAT -III pre- and post-study tasks.
INTRODUCTION: Optimizing perioperative analgesia in patients undergoing abdominal surgery remains a challenge given the side effects of narcotics and the potential for abuse. While transversus abdominis plane block has been shown to improve clinical outcomes, such as decreased opioid consumption and pain scores among adult patients, there is limited data regarding its efficacy for pediatric patients. This study evaluates efficacy amongst pediatric patients undergoing landmark-guided transversus abdominis plane (LTAP) during laparoscopic appendectomy.
METHODS: A retrospective chart review of patients, ages 0-18 years old, who underwent laparoscopic appendectomy for uncomplicated appendicitis at a single institution from January 2021 to December 2022 was conducted. Pearson's chi-square test or Fisher's exact test and Welch's t test were used to assess differences between the two cohorts for categorical and continuous variables, respectively. Results are statistically significant at P < .05.
RESULTS: Of the 90 patients who met inclusion criteria, 40% (n = 36) underwent LTAP block. Those with LTAP block had a shorter average operative time than those without LTAP block (.6 vs .7 hours; P = .009). Similarly, patients with LTAP block had a shorter average time to discharge (4.1 vs 11.0 h; P = .039). There were no other statistically significant differences in postoperative outcomes including narcotic use between both cohorts.
DISCUSSION: Landmark-guided transversus abdominis plane blocks did not increase operative times yet reduced time to discharge for pediatric patients who underwent laparoscopic appendectomy at our institution. Larger studies are needed to evaluate the relationship between LTAP administration and postoperative narcotic consumption to make clinical recommendations.
BACKGROUND: Human MARCH5 is a mitochondria-localized E3 ubiquitin-protein ligase that is essential for the regulation of mitochondrial dynamics. A large body of evidence suggests that imbalances in mitochondrial dynamics are strongly associated with cancer. However, the expression, biological function and prognostic significance of MARCH5 in hepatocellular carcinoma (HCC) have not been determined.
MATERIALS AND METHODS: The mRNA and protein expression of MARCH5 in HCC cell lines and tumor tissues was assessed by real-time quantitative PCR, Western blot analysis and immunohistochemistry. The clinical prognostic significance of MARCH5 was evaluated in 135 HCC patients. Knockdown or overexpression of MARCH5 in HCC cells was determined by in vitro cell proliferation, migration and invasion assays, and in vivo tumor growth and metastasis assays. In addition, the intrinsic mechanisms by which MARCH5 regulates HCC cell growth and metastasis were explored.
RESULTS: MARCH5 was significantly overexpressed in HCC cells and was closely associated with patients' poor postoperative prognosis. In vivo and in vitro experiments revealed that MARCH5 significantly promoted the increase and invasive and migratory ability of hepatocellular carcinoma cells, which was mainly due to the promotion of autophagy by MARCH5. Mechanistic studies revealed that MARCH5 promoted autophagy through ubiquitination degradation of p53 leading to malignant progression of hepatocellular carcinoma.
CONCLUSION: Our findings suggest that MARCH5 plays a critical oncogenic role in HCC cells, which provides experimental evidence for the use of MARCH5 as a potential target for HCC therapy.
Trace elements may play an important role in obesity. This study aimed to assess the plasma and dietary intake levels of four trace elements, Mn, Cu, Zn and Se in a rural Chinese population, and analyse the relationship between trace elements and obesity. A cross-sectional study involving 2587 participants was conducted. Logistic regression models were used to analyse the association between trace elements and obesity; restricted cubic spline (RCS) models were used to assess the dose-response relationship between trace elements and obesity; the weighted quantile sum (WQS) model was used to examine the potential interaction of four plasma trace elements on obesity. Logistic regression analysis showed that plasma Se concentrations in the fourth quartile (Q4) exhibited a lower risk of developing obesity than the first quartile (Q1) (central obesity: OR = 0·634, P = 0·002; general obesity: OR = 0·525, P = 0·005). Plasma Zn concentration in the third quartile (Q3) showed a lower risk of developing obesity in general obesity compared with the first quartile (Q1) (OR = 0·625, P = 0·036). In general obesity, the risk of morbidity was 1·727 and 1·923 times higher for the second and third (Q2, Q3) quartiles of dietary Mn intake than for Q1, respectively. RCS indicated an inverse U-shaped correlation between plasma Se and obesity. WQS revealed the combined effects of four trace elements were negatively associated with central obesity. Plasma Zn and Se were negatively associated with obesity, and dietary Mn was positively associated with obesity. The combined action of the four plasma trace elements had a negative effect on obesity.
In healthy subjects, the oral bioavailability of sotalol hydrochloride is 90 to 100%. After oral administration, peak plasma concentrations are reached in 2.5 to 4 hours, and steady-state plasma concentrations are attained within 2 to 3 days (i.e., after 5 to 6 doses when administered twice daily). Over the dosage range 160 to 640 mg/day sotalol hydrochloride displays dose proportionality with respect to plasma concentrations. Distribution occurs to a central (plasma) and to a peripheral compartment, with a mean elimination half-life of 12 hours. Dosing every 12 hours results in trough plasma concentrations which are approximately one-half of those at peak. 

Sotalol hydrochloride does not bind to plasma proteins and is not metabolized. Sotalol hydrochloride shows very little intersubject variability in plasma levels. The pharmacokinetics of the d and l enantiomers of sotalol are essentially identical. Sotalol hydrochloride crosses the blood brain barrier poorly. Excretion is predominantly via the kidney in the unchanged form, and therefore lower doses are necessary in conditions of renal impairment (see DOSAGE AND ADMINISTRATION). Age per se does not significantly alter the pharmacokinetics of sotalol hydrochloride, but impaired renal function in geriatric patients can increase the terminal elimination half-life, resulting in increased drug accumulation. The absorption of sotalol hydrochloride was reduced by approximately 20% compared to fasting when it was administered with a standard meal. Since sotalol hydrochloride is not subject to first-pass metabolism, patients with hepatic impairment show no alteration in clearance of sotalol. 

Pediatric pharmacokinetic information is approved for Berlex Laboratories’ sotalol hydrochloride tablets. However, due to Berlex’s marketing exclusivity rights, this drug product is not labeled for pediatric use.
PCT No. PCT/EP95/04052 Sec. 371 Date Apr. 4, 1997 Sec. 102(e) Date Apr. 4, 1997 PCT Filed Oct. 16, 1995 PCT Pub. No. WO96/13511 PCT Pub. Date May 9, 1996The present invention relates to polymerizable derivatives of carbohydrates comprising a carbohydrate radical and more than one radically polymerizable hydrocarbon group which is linked optionally via a spacer to the carbohydrate radical, to homopolymers, copolymers, block copolymers, graft copolymers and polymeric networks thereof, to capsules, fibers, films and coatings having water-binding and biocompatible properties, and to molded articles, for example contact lenses or biomedicinal articles, comprising the mentioned polymers, as well as to processes for the preparation of the mentioned polymers and articles.
Women will receive two sub lingual placebo tablets which will be similar in size, color, odor and shape to the misoprostol tablets. Two hour later, Cu T 380A IUD (PREGNA) will be inserted.
The method (10) involves supplying data (105) that is representative of a current morphology of a user i.e. sportsmen, where the data comprises weight and size of the user or a virtual character. A step for defining food intake and physical activity (110) is performed for a predetermined unit of time. A predetermined duration of morphological evolution is estimated (115) according to the food intake and the defined physical activity. An avatar representation of current morphology and estimated morphological evolution are represented (120) on a screen for each predetermined duration. An independent claim is also included for a device for simulation of evolution of morphology of a user or of a virtual character.
<P>PROBLEM TO BE SOLVED: To provide a producing method of a bioglass material for dentistry.  <P>SOLUTION: In this producing method, an oxide biomaterial of which the raw materials are sodium, calcium, silicon and phosphate is ground and dried and then heated and cooled down quickly. The material thus obtained is dried by baking and a phosphoric acid is added thereto. Thereby the bioglass material is obtained. A prosthetic agent for a tooth crack is provided by mixing a bioglass powder with the phosphoric acid and the agent can be mass-produced by a process requiring neither too expensive equipment nor too high cost. By sealing a minute crack of a tooth with the bioglass combined with a carbon dioxide laser, the propagation of the crack can be prevented.  <P>COPYRIGHT: (C)2004,JPO
The invention discloses a composition with anoxia tolerance and fatigue resistance. The composition is prepared from the following active ingredients: longan aril, Chinese-dates, prepared rehmannia root, the fruit of Chinese wolfberry, walnut kernel, schisandra chinensis, cinnamon and corn cervi pantotrichum. The invention also discloses an application of the composition in preparation of health foods with anoxia tolerance and fatigue resistance. The health foods in the invention have the effects of promoting anoxia tolerance, resisting fatigue and enhancing the health conditions. The health foods are prepared by taking natural Chinese herbal medicines as main raw materials and can be taken for a long time. The result of the functional science test proves that the health foods disclosed by the invention have the anoxia tolerance and fatigue resistance and are obvious in effects.
Roflumilast placebo-matching tablets, orally, once, daily, Days 1 through 8, Period 1, followed by a 14 day washout period, followed by roflumilast 100 μg tablets, orally, once, daily, Days 1 through 8, Period 2, followed by a 14 day washout period, followed by roflumilast 250 μg tablets, orally, once, daily, Days 1 through 8, Period 3. All participants will take a stable dose of second generation antipsychotics throughout the duration of the treatment period.
We will conduct a block randomized controlled trial (RCT) comparing an intervention group and a waitlist control group. Participants in the intervention group will complete the Eat Breathe Thrive (EBT) Yoga for Eating Disorder Recovery online course. This course will be led by certified facilitators via Zoom and offered over the course of four weeks, comprising one two-hour session per week. The course will continue to recruit and enroll participants until sufficient power is reached for the study. At Pretest, Posttest 1, Posttest 2, and three-months Follow-Up, participants will complete a series of self-report measures (see point 12.3). Participants in the waitlist control group will only be engaged in the study assessment procedures. However, they will be given the opportunity to take part in the Yoga for Eating Disorder Recovery online course that was delivered to the intervention group, once Posttest 1 has been completed by both groups.
Carpal tunnel syndrome (CTS), or median neuropathy at the wrist, is a medical condition in which the median nerve is compressed at the wrist, leading to paresthesia, numbness and muscle weakness in the hand. It's the most common neuro-compressive disease. With the development of the modern life, the morbidity of CTS is also raised. As a common disease, the study on etiology is very important in Carpal Tunnel Syndrome, which can improve the life quality of patients with carpal tunnel syndrome. The risk factors include individual factors such as age, gender, diabetes, Hypothyroidism, obesity, complication of systematic diseases, tobacco, injury and occupational factors.

As most of the research were based on the population in western country and the life style and the ethnicity between Chinese people and western country people is quite different, there may be some similarities and differences in epidemiology. There is seldom similar research in China so that this study was conducted to observe the characteristics of these risk factors in Chinese population.