anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: This study aimed to assess the frequency with which orthodontic patients decided to shift to another type of orthodontic appliance, among conventional metal brackets, ceramic brackets, lingual brackets and clear aligner, based on their personal experiences of pain, ulcers, bad breath, hygiene issues and social difficulties.
MATERIAL AND METHODS: This study comprises of patients seeking orthodontic treatment. The sample (n = 500; age group = 19-25 years) was divided equally into four groups based on the treatment modality: conventional metal brackets, ceramic brackets, lingual brackets and clear aligner. Patients rated the questionnaire using a visual analogue scale, to assess variables (such as pain, ulcer etc) that impact various treatment modalities. Subsequently, patients from all groups provided feedback regarding their treatment experiences, and expressed their preference for an alternative modality. Intergroup comparison among the four groups was done using one-way analysis of variance with Tukey's HSD post-hoc test (p ≤ 0.05).
RESULTS: Patients who received lingual brackets reported higher levels of pain and ulceration, as compared to those who received clear aligners. All four groups showed statistically significant differences for ulcers during treatment (p ≤ 0.05). Of the 125 patients who received conventional metal brackets, 28% expressed a preference for clear aligner therapy, while 20% preferred ceramic brackets. In the lingual group, 56% of 125 patients preferred clear aligner therapy, and 8% preferred ceramic brackets to complete their treatment. In the ceramic group, 83% did not want to switch, whereas 17% desired to switch to clear aligner, while in aligner group no patient desired to switch.
CONCLUSIONS: A higher percentage of patients from lingual brackets group chose to shift to clear aligners, followed by conventional metal brackets group and by ceramic brackets group, in this descending order. The clear aligner group demonstrated fewer issues than the other treatment modalities.
Teduglutide, 3 mg, subcutaneous (SC) injection using a syringe, once on Day 1 of Treatment Period 1 (Treatment A1), followed by same dose SC pen injector, once on Day 1 of Treatment Period 2 (Treatment B1). A Washout Period of 7 days was maintained between Treatment Periods 1 and 2. Participants with \>=40.0 kg to \<=75.0 kg of weight were included in Cohort 1.
Returning citizens with substance use disorders (SUD) are at the greatest risk for overdose in the first two weeks following the transition from incarceration. Thus, the reentry period is of specific importance for ensuring individuals are engaged and retained in specialized intervention services. Individuals also face numerous, and highly impactful, decisions during this period. They are required to navigate complex tasks (finding employment, securing housing), often with limited financial and social supports. Of particular concern, recent research suggests that the reentry period, often characterized by instability and limited resources, may reinforce a decision-making approach that favors meeting immediate needs relative to engaging in long-term planning. This focus on attaining smaller but immediately available rewards relative to larger, delayed, rewards (known as delay discounting), in turn, has been associated with a number of negative health outcomes, including substance use and poor treatment outcomes (higher dropout and lower motivation). In other words, the reentry context may create an environment which reinforces individuals' tendencies to engage in short-term, reward-seeking behaviors (e.g. substance use, skipping treatment appointments) at a time when their decisions have highly significant consequences (relapse, recidivism). This study will examine the efficacy of implementing a low-cost, brief intervention (Episodic Future Thinking) targeting the reduction of delay discounting with the reentry population to inform broader public health efforts aimed at reducing substance misuse and improvements in treatment outcomes.
An 8-week Internet-delivered cognitive behavioural therapy (ICBT) will be delivered to clients. Clients will receive weekly support in the form of emails and phone calls from registered social workers, psychologists or supervised graduate students, who have experience delivering ICBT. Therapist will spend approximately 15 minutes per week/per client.
428,932. Hair-waving. JACKSON, L. MELLERSH-, 28, Southampton Buildings, Chancery Lane, London.-(Zotos Corporation; 33, West 46th Street, New York, U.S.A.) Oct. 16, 1933, No. 28642. [Class 131] Hair is waved by forming a tress about a suitable mandrel or other shape, moistening the tress with an aqueous alkaline solution containing a sulphonated organic material as, for instance, an alkyl naphthalene sulphonic acid or a sulphonated product of an aryl hydrocarbon containing ten or more hydrocarbon atoms in the hydrocarbon portion of the molecule including one or more alkyl groups, with or without a higher alcohol such as linalvol or terpineol, and applying heat to the moistened formed tress. Sulphonated organic materials specified are turkey red oil, isopropyl and isobutyl naphthalene sulphonic acids, abietene sulphonate and lauric acid sulphonate.
Participants were provided with a placebo comparator that included frozen 70 gram breakfast muffins and pre-mixed powder packets to prepare smoothies. Participants were asked to consume one muffin package and one smoothie (mixed with water or choice of milk/milk substitutes) daily for 14 days. These foods were formulated to taste and appear similar to the cricket intervention foods but did not consume any cricket powder.
The invention discloses an external unguent for treating burn. The unguent comprises the following raw materials in parts by weight: 20-30 parts of sensitive plant, 10-15 parts of lithospermum, 10-15 parts of golden cypress, 10-12 parts of peperomia dindygulensis miq, 6-10 parts of flos paulowniae, 10-14 parts of ophiopogon root, 10-13 parts of radix rehmanniae recen, 8-10 parts of dandelion, 10-14 parts of fried garden burnet, 10-13 parts of pseudo-ginseng, 6-8 parts of flowers carthami, 3-4 parts of the root of kudzu vine, 3-5 parts of madder, 4-7 parts of Coptis chinensis, 10-12 parts of rhizoma bletillae, 8-11 parts of rhizoma atractylodis, 10-13 parts of Ixeris japonica, 6-7 parts of mint, 2-3 parts of Elaeagnus, 3-4 parts of liquorice, 8-10 parts of ash bark, 4-5 parts of dried alum, 10-15 parts of rosin, 6-10 parts of radix sophorae flavescentis, 6-10 parts of smoked plum, 10-12 parts of borneol, 200-260 parts of sesame oil and 100-150 parts of beewax. The unguent disclosed by the invention has the effects of preventing bacteria, diminishing inflammation, relieving pain, eliminating swelling and resisting irritability. The infection probability is low, and the burn is not specially treated. The unguent has low sterile demand to the trauma and is simple in using method. The unguent is not combined with other antibiotics, and the unguent is short in curative period, quick-acting and free from scars.
The prediction of liver-related events (LRE) after sustained virological response (SVR) in HCV-advanced chronic liver disease (ACLD) patients is crucial. We aimed to evaluate incidence and risk factors of LRE in HCV-cirrhotic patients after SVR and to assess dynamic changes of liver stiffness in participants without LRE at the end of follow-up. We enrolled 575 consecutive patients with HCV-ACLD treated with DAAs and followed up for 5 years after SVR12. Overall, 98 (17%) patients developed any type of event, and HCC was the most frequent LRE. The incidence rate was 1.6 per 100 person-years (p/y) for both HCC and hepatic decompensation. Baseline LSM ≥ 20 kPa was the only independent predictor of hepatic decompensation, while LSM ≥ 20 kPa and male sex were independent predictors of HCC development. Among the 341 participants without LRE and with paired LSM, any LSM reduction was observed in 314 (92.1%), and half of them showed a decrease of LSM ≥ 20%. Among patients without LRE, 27.3% of participants without ≥20% LSM decrease at 2 years achieved the 5-year goal; in contrast, 31.6% of participants with ≥20% LSM decrease at 2 years lost it at 5 years. These findings provide evidence that baseline LSM is a tool to stratify patients at risk of developing LRE; the dynamic changes of LSM value suggest the need for monitoring this parameter over time.
Rapid alkalinization factors (RALFs), belonging to a family of small secreted peptides, have been considered as important signaling molecules in diverse biological processes, including immunity. Current studies on RALF-modulated immunity mainly focus on Arabidopsis, but little is reported in crop plants. The rice immune receptor XA21 confers immunity to the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae (Xoo). Here, we pursued functional characterization of rice RALF26 (OsRALF26) up-regulated by Xoo during XA21-mediated immune response. When applied exogenously as a recombinant peptide, OsRALF26 induced a series of immune responses, including pathogenesis-related genes (PRs) induction, reactive oxygen species (ROS) production, and callose deposition in rice and/or Arabidopsis. Transgenic rice and Arabidopsis overexpressing OsRALF26 exhibited significantly enhanced resistance to Xoo and Pseudomonas syringae pv. tomato DC3000 (Pst DC3000), respectively. In yeast two-hybrid, pull-down assays, and co-immunoprecipitation analyses, rice FER-like receptor 1 (OsFLR1) was identified as a receptor of OsRALF26. Transient expression of OsFLR1 in Nicotiana benthamiana leaves displayed significantly increased ROS production and callose deposition after OsRALF26 treatment. Together, we propose that OsRALF26 induced by Xoo in an XA21-dependent manner is perceived by OsFLR1 and may play a novel role in the enforcement of XA21-mediated immunity.
The invention discloses a bog bilberry anthocyanin tablet and a preparation method thereof, and relate to a bilberry anthocyanin tablet which has the effect of lowering blood fat and a preparation method thereof. In China, the conventional anthocyanin product is mainly integrated in few types such as beverages, fruit wines, effervescent tablets, capsules and the like. The variety of the anthocyanin product in China is enriched, and the anthocyanin product has the effects of lowering fat and protecting health. The anthocyanin tablet is prepared from bog bilberry anthocyanin, lactose, dry starch, starch slurry and magnesium stearate. The method comprises the following steps of: putting bog bilberry anthocyanin, lactose and dry starch into a mixing machine for stirring uniformly, adding starch slurry serving as a bonding agent for stirring continually, fully bonding, and granulating by adopting a wet method; drying prepared particles, granulating once again and dispersing into uniform dry particles; and putting the dry particles into a tableting machine for tableting. The bog bilberry anthocyanin tablet has the effects of lowering fat and protecting health, and is a good health-care product for long-term use.
Inflammatory bowel disease (IBD) is a chronic condition that includes ulcerative colitis and Crohn's disease. It is characterized by a relapsing and remitting pattern that negatively impacts quality of life (QoL). Current goals of treatment involve symptomatic, biochemical, and endoscopic remission in a treat-to-target approach. Despite effective treatment and remission of IBD, many patients report frequent and isolated abdominal pain. A wide range of etiologies exist, including surgery-related, infections, pelvic conditions, immune-related, and systemic illnesses. Disorders of the gut-brain interaction (DGBI), frequently characterized by abdominal pain, are increasingly recognized in IBD patients, including those with quiescent disease. Various mechanisms are involved and numerous non-pharmacologic and pharmacologic therapies have been proposed. Hereby, we outline the pertinent findings of the literature on management of chronic abdominal pain, focusing on quiescent IBD.
CCT intervention. 8 weeks with 2 hours session every week. Homework approx. 25 min. of meditation daily.
The present invention provides a foodstuff comprising vitamin C, taurine, curcumin and aloe vera and its use in the control of skin disorders. Preferably, the foodstuff additionally comprises Vitamin A, zinc and one or more fatty acids selected from eicosapentaenoic acid, docosahexaenoic acid, alpha-linolenic acid or gamma-linolenic acid. The foodstuff of the invention assists in the management of a skin disorder such as inflammatory or allergic skin disorders. The foodstuff further assists in the management of secondary infections associated with the skin disorder. Use of the foodstuff may allow the reliance on conventional treatments for skin disorders to be reduced. Preferably, the skin disorders to be treated are atopy, food sensitivity, contact allergy, dermatitis, flea allergy, pruritis, alopecia or inflammation.
The invention concerns in-air polymerization of liquid jets as a novel platform to produce microparticles and micro-fibres with tunable size, shape, and composition at high throughput (>100 ml/h per nozzle). The polymerization kinetics may be modelled as a function of the ink composition, the UV light intensity, and the velocity of the liquid jet, enabling engineering of complex micro-materials in jetting regimes. The size, morphology, and local chemistry of micro- materials are independently controlled, as highlighted by producing micro-materials using a number of different photo-polymers as well as multi-material composites. Simultaneous optimization of these control parameters yields rapid fabrication of stimuli-responsive Janus fibres that function as soft actuators. Also, in-air photo-polymerization enables control over the curvature of printed droplets, as highlighted by high-throughput printing of micro-lenses with tunable focal distance. The combination of rapid processing and tunability in composition and architecture opens a new route towards applications of tailored micro-materials in soft matter, medicine, pharmacy, and optics.
In the go/no go training, participants are shown images in which high-calorie foods are shown on one side of the screen and low-calorie foods on the other. They are told to press response keys as quickly as possible to indicate the side of presentation (go-trials). On half of the trials, the rectangular frame surrounding the image is not solid but hatched, which is a signal for them to withhold their response (no-go trials). This training is divided into 4 blocks of 50 trials.
Infusion of GPRC5D-CD19 CAR T cells injection by dose of 1.0×10\^6 /kg±20 % CAR-T ，3.0×10\^6 /kg±20%、6.0×10\^6 /kg±20%. Administration method: intravenous infusion. Subjects will be treated with Fludarabine and Cyclophosphamide before cell infusion.
The invention discloses an RNA aptamer for recognizing and combining human colorectal cancer cells and application thereof. The invention provides a complete set of RNA nucleic acid aptamers for recognizing and binding to human colorectal cancer cells, which consists of all or part of the 5 aptamers shown in SEQ ID No.1 to SEQ ID No. 5. These nucleic acid aptamers were obtained by a single/oligo round screening method designed based on the traditional Cell-SELEX technique, combining UMI and high throughput sequencing techniques. The method can simultaneously obtain a plurality of nucleic acid aptamers with different targets, the nucleic acid aptamers have different binding modes on normal cells and tumor cells from different sources, and the molecular typing of the normal cells and the tumor cells from different sources can be realized according to the different binding modes. In addition, the invention has important significance for physiological and pathological research and treatment diagnosis related to intestinal cancer.
PROBLEM TO BE SOLVED: To provide a method and a kit for using an automatic injection device, and to provide a method and a kit for training a recipient about the use of the automatic injection device.SOLUTION: An automatic injection device 10 incudes a first detachable cap 24 (or a needle cap) that covers a first end 20 of a housing 12 and prevents a needle of a syringe from being exposed before use. The first cap includes a protrusion 26 that fixes and/or covers an internal component of the device until a user is ready to start up the device. The syringe is slidably attached to the housing. The syringe at a non-start position is housed in the housing and is sucked. When the device operates, the needle of the syringe protrudes from a first (proximal) end of the housing and then emits a material from the syringe to a patient. As shown in the Figure, the first end of the housing, namely the proximal end, includes an opening 28 where the needle of the syringe protrudes during the operation of the device.
OBJECTIVE: Periventricular-intraventricular hemorrhage is the most common type of intracranial bleeding in newborns, especially in the first 3 days after birth. Severe periventricular-intraventricular hemorrhage is considered a progression from mild periventricular-intraventricular hemorrhage and is often closely associated with severe neurological sequelae. However, no specific indicators are available to predict the progression from mild to severe periventricular-intraventricular in early admission. This study aims to establish an early diagnostic prediction model for severe PIVH.
METHOD: This study was a retrospective cohort study with data collected from the MIMIC-III (v1.4) database. Laboratory and clinical data collected within the first 24 h of NICU admission have been used as variables for both univariate and multivariate logistic regression analyses to construct a nomogram-based early prediction model for severe periventricular-intraventricular hemorrhage and subsequently validated.
RESULTS: A predictive model was established and represented by a nomogram, it comprised three variables: output, lowest platelet count and use of vasoactive drugs within 24 h of NICU admission. The model's predictive performance showed by the calculated area under the curve was 0.792, indicating good discriminatory power. The calibration plot demonstrated good calibration between observed and predicted outcomes, and the Hosmer-Lemeshow test showed high consistency (p = 0.990). Internal validation showed the calculated area under a curve of 0.788.
CONCLUSIONS: This severe PIVH predictive model, established by three easily obtainable indicators within the NICU, demonstrated good predictive ability. It offered a more user-friendly and convenient option for neonatologists.
Striae distensae (SD) are a prevalent dermatological concern of women and approximately 90% of pregnant women experience these stretch marks. Fractional microneedle radiofrequency (FMR) and fractional CO2 laser (FCL) have gained substantial attention in the treatment of SD. In clinical studies, a clear superiority between FMR and FCL treatments is not found due to limited studies and sample sizes. In this systematic review and meta-analysis, a search of English-language articles was performed on PubMed, employing various combinations of keywords "fractional CO2 laser," "microneedle radiofrequency," and "striae". Studies that compared the treatments of FMR and FCL for SD and provided data regarding professional evaluation of improvement, patient self-assessment, and/or the presence of post-inflammatory hyperpigmentation (PIH) were included. We analyzed the incorporated studies utilizing both random and fixed-effects models to estimate pooled odds ratios (OR) and 95% confidence intervals (CI). Professional assessments of improvement showed no statistically significant difference between the FMR and FCL groups (OR: 1.27; 95% CI: 0.49-3.31). Similarly, patient self-assessments of improvement did not exhibit a significant difference (OR: 0.72; 95% CI: 0.13-3.90). However, the development of PIH was significantly less frequent in the FMR group when compared to the FCL group (OR: 0.24; 95% CI: 0.08-0.70). Both FMR and FCL demonstrate comparable performance in terms of improving lesions, as assessed by both healthcare professionals and patients. However, FCL is associated with a higher risk of developing PIH. This finding can guide clinicians especially who prefer a single treatment.
Sarcoidosis is a chronic disease involving lung and mediastinum in more than 90% of cases. Five to 25% of thoracic sarcoidosis are complicated by a severe fibrotic lung disease. Computed tomography (CT) is critical for the diagnosis of thoracic sarcoidosis as well as for therapeutic management. Repeated CT examinations, sometimes all life long, raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Based upon tube voltage and current reduction as well as iterative recontsruction, ultra-low dose CT (ULD CT) allows to lower the dose up to that of a traditional chest X-ray. Magnetic resonance imaging (MRI) using Ultrashort echo time (UTE) enables lung parenchyma imaging with high signal-to-noise and spatial resolution.
Women diagnosed with ovarian cancer frequently have a poor prognosis as their cancer is often diagnosed at more advanced stages when the cancer has metastasized. At this point surgery cannot remove all the tumor cells and while ovarian cancer cells often initially respond to chemotherapeutic agents like carboplatin and paclitaxel, resistance to these agents frequently occurs. Thus, novel therapies are required for the treatment of advanced stage ovarian cancer. One therapeutic option being explored is the regulation of non-coding RNAs such as microRNAs. An advantage of microRNAs is that they can regulate tens, hundreds and sometimes thousands of mRNAs in cells and thus may be more effective than chemotherapeutic agents or targeted therapies. To investigate the therapeutic potential of miR-200s in ovarian cancer, lentiviral vectors were used to overexpress both miR-200 clusters in two murine ovarian cancer cell lines, ID8 and 28-2. Overexpression of miR-200s reduced the expression of several mesenchymal genes and proteins, significantly inhibited proliferation as assessed by BrdU flow cytometry and significantly reduced invasion through Matrigel coated transwell inserts in both cell lines. Overexpression of miR-200s also increased basal apoptosis approximately 3-fold in both cell lines as determined by annexin V flow cytometry. Pathway analysis of RNA sequencing of control and miR-200 overexpressing ovarian cancer cells revealed that genes regulated by miR-200s were involved in processes like epithelial mesenchymal transition (EMT) and cell migration. Therefore, miR-200s can inhibit proliferation and increase apoptosis while suppressing tumor cell invasion and thus simultaneously target three key cancer pathways.