anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A cosmetic composition containing sodium polyacrylate and water soluble polymers is provided to ensure soft property and skin moisturizing and softening effect. CONSTITUTION: A cosmetic composition contains 1.5-2.5 wt% of sodium polyacrylate and 0.25-0.5 wt% of water soluble thickening agent. The water soluble thickening agent is cellulose gums, xanthan gums, gellan gums, or agar. The cellulose gums are C.M.C-Na or cationic cellulose powder. The xanthan gums and gellan gums are Keltro-F and KELCOGEL, respectively. The composition is used as a mask pack.
Patients with localized prostate cancer - negative PSMA PET CT +/- standard staging exams (bone scan, CT, MRI)-enrolled in this study, will be treated to prostate/prostate seminal vesicles (according to the risk group) to a total dose of 24 Gy delivered in 1 fraction, with a urethral sparing HDR like technique. For unfavorable intermediate and high-risk pts, Androgen Deprivation Therapy (ADT) will be prescribed for 6 and 24 months, respectively. The procedure will be performed in just one day, from fiducials implantation to radiation treatment delivery.
A dialysis system is configured to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments. The example dialysis system includes a base unit configurable to provide a first fluid for use in preforming at least one peritoneal dialysis treatment at a first time. The base unit is further configurable to provide a second, different fluid for use in at least one extracorporeal blood treatment at a second, different time. The example dialysis system also includes a blood treatment unit configured to be docked to the base unit. The blood treatment unit includes a blood pump configured to pump blood from the patient to a blood filter and from the blood filter back to the patient. The blood filter or a blood line in communication with the blood filter receives the second fluid from the base unit for use in the at least one extracorporeal blood treatment.
Recent evidence from our group shows that individualization of the sodium concentration in the dialysate to match the patient's own serum sodium results in less thirst, less interdialytic weight gain, less HD-related symptoms, and better blood pressure control in hypertensive subjects. In this project we will evaluate the effect of dialysate sodium individualization on systemic hemodynamics, body volume compartments and biochemical markers of volume control in hypertensive hemodialysis patients. We will use a single-blind cross-over design with randomized blocks. After a 3-week baseline period where pre-HD serum sodium will be measured weekly to establish each patient's average serum sodium, subjects will be randomized to 3 weeks on standard dialysate sodium (140 mmol/L) or individualized dialysate sodium (same concentration as the average pre-HD serum sodium during the baseline period), then crossed over to the other for another 3 weeks after a 1-week washout period (dialysate Na 140 mmol/L). The remainder of the dialysis prescription, prescribed dry weight and vasoactive drugs will remain unchanged throughout the study. Clinical information, pre/intra/post-HD blood pressure and thirst scores will be measured weekly at the mid-week dialysis session. In addition, we will measure systemic hemodynamics (cardiac output and systemic vascular resistance), bioimpedance measurements of intracellular and extracellular volume, arterial stiffness (aortic augmentation index, aortic pulse wave velocity), interdialytic (44h) ambulatory BP monitoring, and plasma BNP, renin, aldosterone and norepinephrine at baseline and at the end of each block.
Participants in the OTES group were treated with a Chattanooga direct Tens device (DJO UK Ltd, Guildford Surrey, United Kingdom) 3 times a week for 5 weeks. Four self-adhesive 40\*40 mm sized electrodes were attached to the occipital region of the patients bilaterally, covering the occipital nerves. The current intensity was adjusted according to the patient. The current intensity started from 0 mA and the current intensity was increased one by one every 30 seconds, the patient was allowed to tolerate the current by giving current without muscle twitching or harmful stimulation. The current frequency was determined as 2/100 Hz. Square waves at 2 Hz were applied for 3 seconds followed by an automatic shift to 100 Hz for another 3 seconds.
The present invention relates to a traditional Chinese medicine compound medicine, particularly to a medicine for treating urinary tract infection. The existing medicine for treating urinary tract infection has the disadvantages of high toxicity and manifestation treatment without treatment of root causes of diseases. The medicine of the present invention is composed of the traditional Chinese medicines of the following portions by weight: 275 to 315 portions of oldenlandia diffusa, 275 to 315 portions of motherwort herb, 98 to 138 portions of common knotgrass herb, 98 to 138 portions of lilac pink herb, 98 to 138 portions of plantain seed, 98 to 138 portions of phellodendron bark, 157 to 197 portions of barbed skullcap herb, 157 to 197 portions of honeysuckle flower, 98 to 138 portions of forsythiae, 98 to 138 portions of tuckahoe, 157 to 197 portions of Chinese waxgourd peel, 98 to 138 portions of red peony root, 98 to 138 portions of giant knotweed, 98 to 138 portions of cassia twig and 39 to 79 portions of licorice root. The medicine of the present invention has the functions of heat clearing, diuresis promotion, blood cooling and detoxifcation. The medicine is used for relieving symptoms of urinary system infection caused by downward flow of damp-heat. The product of the present invention has the advantages of no toxic side effect, and treatment of both manifestation and root causes of diseases.
The invention provides granules for treating rheumatism bone pain and a preparation method thereof. The granules comprise soluble starch and lactose as well as earthworms, astragalus, peach kernels, angelica sinensis, red paeony roots, salvia miltiorrhiza and caulis spatholobi extract. The angelica sinensis is sweet-warm and nourishing in nature, has the effect of enriching the blood, is matched with the astragalus to achieve the effects of invigorating qi and promoting blood and regulating menstruation and relieving pain, and is combined with the peach kernels to be capable of treating blood stasis and amenorrhea. The caulis spatholobi and angelica sinensis are combined to achieve the effects of nourishing the liver and kidneys and invigorating the circulation of blood and relaxing muscles and tendons. When the caulis spatholobi is used for treating rheumatism, numbness of limb, inhibited bending and stretching and arthralgia and myalgia, the caulis spatholobi can be matched with the earthworms to achieve the effects of activating blood, dredging collaterals and dispelling wind and promoting blood circulation to remove blood stasis. Compared with the prior art, the granules disclosed by the invention have the advantages that the components supplement each other and are combined to achieve the effects of dispelling wind and dissipating dampness and treating bone pain and have the effect of effectively relieving symptoms of patients suffering from rheumatism bone pain. Moreover, the granules are fast in absorption, rapid in efficacy and good in taste, and are capable of regulating multiple internal organs during treatment and continuously improving the immunity.
Colorectal cancer (CRC) is the third leading type of cancer and the third leading cause of cancer death in the United States. This study focuses on improving CRC screening in The Ohio State University Primary Care Network (OSUPCN). Ohio has higher than average rates of CRC mortality compared to the rest of the US. The study population for this study will also include minority and older individuals as these groups have higher CRC incidence and mortality rates.

The goal of this study is to test a program to improve CRC screening among male and female patients over the age of 50 in 10 primary care clinics. This study will use physician surveys, focus groups and a community advisory board to finalize the content of the interventions. Five theoretical models form the theoretical framework of the study - the health belief model, social networking, minority health communications model, PEN III, and the transtheoretical model. The interventions will be directed at the clinic and patient levels, and will be tested in a randomized design. Five clinics will receive the clinic plus patient-directed interventions and 5 clinics will be randomized to usual care. The clinic intervention will consist of provider, system and waiting room activities. The individual-directed intervention will include three stepped stages for patients who have not yet been screened: (1) a tailored physician letter, easy-to-read educational materials about CRC and an FOBT information sheet and card; (2) follow-up telephone barriers counseling for patients who do not complete CRC screening after receiving the letter; and (3) in person home visits by lay health advisors (LHA) for those who do not complete CRC screening after receiving the first two interventions. Research staff will conduct a process evaluation of the interventions to identify problems in implementing them and determine the extent to which each of the components is successfully carried out. They will also examine how components of the intervention relate to the theoretical frameworks used to motivate CRC screening completion. If successful, this program can easily be adapted for use by primary care practices and clinics to improve CRC screening.
OBJECTIVE: Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2 interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions. However, their roles in pulpitis are unclear. Therefore, the changes in inflammatory response and autophagy levels caused by hypoxia during pulpitis were evaluated. Additionally, the regulatory mechanism of HIF-1α/BNIP3 in cellular autophagy in pulpitis was explored.
DESIGN: Pulp from dental pulp tissues of healthy individuals and patients with pulpitis (n = 10) were exposed and combined with a low oxygen simulation chamber to construct pulpitis (n = 6), hypoxia (n = 6), and hypoxia+pulpitis (n = 6) rat models. Hematoxylin and eosin and immunohistochemical staining were used to detect the localization and expression levels of HIF-1α, BNIP3, and autophagy marker protein, LC3B. Transmission electron microscopy was used to confirm autophagosome formation. An in vitro hypoxic model of human dental pulp cells was established, and HIF-1α chemical inhibitor 3-(5'-hydroxymethyl-2'-furyl)- 1-benzylindazole (YC-1) was administered. Immunofluorescence and western blotting were used to detect the localization and protein levels of HIF-1α, BNIP3, and LC3B.
RESULTS: Autophagy is significantly increased and HIF-1α and BNIP3 are elevated in inflamed dental pulp tissue. Both pulp exposure and hypoxia intervention cause inflammatory reactions in rat dental pulp tissue, accompanied by the autophagy activation. Hypoxia significantly enhances HIF-1α/BNIP3 and autophagy activation. BNIP3 downregulates and autophagy reduces after treatment with YC-1.
CONCLUSIONS: In pulpitis, activation of the HIF-1α/BNIP3 signaling pathway driven by hypoxia leads to increased autophagy. This provides a new molecular explanation for autophagy activation in apical periodontitis and new insights into the pathogenesis of the disease.
Although real-time event detection during video EEG recording is required to ensure patients' safety, it is limited by the technologists' availability. We sought to explore the efficiency of real-time event detection by the EEG technologists in a single tertiary academic center. We retrospectively reviewed events from continuous inpatient video EEGs (cEEGs) and epilepsy monitoring unit (EMU) recordings in January 2017, when real-time surveillance was only available during the night shift, and June 2017, when a dedicated neurodiagnostic EEG technologist was available for real-time monitoring during all shifts. The events were categorized into those detected immediately (eyes-on), later in the same shift (delayed) or identified on the subsequent shift (missed). Chi-square and Fisher's exact tests were used for statistical comparisons. In January 2017, there were 25 patients (117 days of monitoring) in the EMU and 54 inpatients (146 days of monitoring) on cEEG with 92 total events, (39% seizures). In June 2017, there were 30 patients (133 days of monitoring) in the EMU and 47 additional inpatients (80 days of monitoring) on cEEG with 110 total events, (39% seizures). The number of events identified in real time was low and did not significantly differ among shifts regardless of the availability of the monitoring technologist. Most events were identified at the time of subsequent EEG scanning by the EEG technologist. Partial staffing for continuous video EEG surveillance is insufficient to identify events in real time. EEG technologists are able to identify events during regular EEG scanning.
The invention relates to Chinese patent medicine plasters, particularly a plaster for treating acute diarrhea of children. The formula of the plaster for treating acute diarrhea of children comprises 3-5g of nutgall, 3-5g of pepper, 15-25g of ginger and 15-20g of table vinegar. The preparation method of the plaster comprises the following steps: pulverizing the nutgall, pepper and ginger, adding the table vinegar to obtain paste, applying the paste onto a rubberized fabric to obtain a plaster, and attaching a protective film on the surface of the plaster. Children have pure yang constitutions, tissues and organs of the children are growing and are not completely mature, and therefore, the children have poor resistance and insufficient vital qi; and due to exogenous pathogenic factors, children suffers from cold-damp invasion of the spleen, dysfunction of the spleen in transport, internal damage caused by infantile dyspepsia, injury of the spleen and stomach or weakness of the spleen and stomach, so that foodstuff can not be transported and transformed, causing diarrhea. According to the formula, the plaster for treating acute diarrhea of children can disperse cold, relieve pain and also relieve diarrhea with astringents. The plaster is applied onto the navel of a child, and thus, is very convenient to use and can not irritate the child. The curative effect of the plaster is good, and the total effective rate is up to 97%. The plaster has the advantages of high safety and no toxic or side effect, and can be applied in a common way.
The stress ball, one of the distraction methods, is an effective technique for ensuring cognitive focus. It has been observed that the stress ball method is used to reduce patients' anxiety and pain. Squeezing a stress ball during a surgical procedure allows patients to have direct control over the object, enhancing their feelings of empowerment. In this way, it positively impacts anxiety and patient satisfaction without interfering with the surgical process. In the study by Yanes et al., the effects of the stress ball and hand-holding on pain, anxiety, and satisfaction were evaluated during skin cancer surgery performed under local anesthesia. Although anxiety was observed to decrease in all groups, no significant difference was found between the groups regarding pain and anxiety. It was noted that nearly all participants were very satisfied. The use of the stress ball appears to help reduce anxiety in anxious patients prior to the procedure. In a study conducted by Kasar et al. on hemodialysis patients, the effects of stress ball usage on stress, vital signs, and comfort levels were investigated. While the use of the stress ball did not affect vital signs and comfort, it demonstrated a positive impact on stress. In a study investigating the effects of distraction methods used during cystoscopy on pain, anxiety, and satisfaction, it was found that anxiety levels post-procedure were lower in the intervention groups (music, video, and stress ball) compared to the control group, while satisfaction levels were higher . Another randomized controlled study evaluated the effectiveness of three different non-pharmacological methods (coughing technique, spirometer blowing, and squeezing a stress ball) in reducing pain during intravenous catheterization. It was reported that the average pain levels in the coughing, spirometer, and stress ball groups were lower compared to the control group . In a study examining the effectiveness of distraction methods for pain and anxiety management during invasive venous surgical procedures, it was indicated that pain and anxiety levels were significantly lower in the interaction with nurses and stress ball group . In a study on managing dental anxiety with the application of a stress ball, no significant difference was found between the anxiety scores of patients who used the stress ball and those who did not. Similarly, in another study investigating the effects of distraction methods during lithotripsy, no significant difference was observed in pain and anxiety scores between the control and intervention groups (music and stress ball) .
Chronic obstructive pulmonary disease COPD is a preventable and treatable disease(GOLD, 2017). According to the WHO, COPD would be the third leading cause of death by 2030 (WHO, 2017). This disease is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases(GOLD, 2017). However, emerging data showed that COPD patients demonstrate important deficits in balance and control which associated to a high risk of fall ( Butcher et al, 2004 ; Smith et al, 2009 ; Beauchamp et al, 2009 ; Beauchamp et al, 2010). Inspiratory muscle training (IMT) has been shown to be an effective modality for COPD patients for improving the maximal inspiratory muscle strength, the dyspnea and health-related quality of life (GI COPD, 2016). However, the effect of inspiratory muscle training on balance is not studying. The purpose of this study is to evaluate the effect of the inspiratory muscles training on balance in COPD patients.
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood cells to attach to. In circulation, neutrophils are constantly exposed to hemodynamic forces such as shear stress, which in turn regulates many of their biological functions such as crawling and NETosis. However, the mechanisms that mediate mechanotransduction in neutrophils are not fully understood. In this study, we demonstrate that shear stress induces NETosis, dependent on the shear stress level, and increases the sensitivity of neutrophils to NETosis-inducing agents such as adenosine triphosphate and lipopolysaccharides. Furthermore, shear stress increases intracellular calcium levels in neutrophils and this process is mediated by the mechanosensitive ion channel Piezo1. Activation of Piezo1 in response to shear stress mediates calpain activity and cytoskeleton remodeling, which consequently induces NETosis. Thus, activation of Piezo1 in response to shear stress leads to a stepwise sequence of cellular events that mediates NETosis and thereby places neutrophils at the centre of localized inflammation and prothrombotic effects.
The study involves each patient presenting for an initial MRI with a regular dose of gadolinium and then presenting at least 48 hours after (no less than 14 days later) for a ¼ dose (see below regarding dosing) gadolinium MRI exam. Both exams will be performed on a 1.5 Tesla magnet. Both exams will include a full protocol. The full dose contrast exam will be read as standard protocol. All images will be anonymized. Images from the reduced dose study will be collected and an AI algorithm applied. All three anonymized data sets (regular dose, low dose, and AI algorithm applied to low dose) will be provided to the readers.

Readers will be three attending radiologists specializing in breast imaging. Exams will be scored on quality, background parenchymal enhancement (BPE), and lesion conspicuity. Enhancing lesions will be identified and characterized by the radiologists in a document provided.
Patients in the study group will receive MRI-guided adaptive stereotactic radiotherapy (without PTV expansion margin). The total dose will be 30Gy/5 fractions, administered once daily. The MRI-linac is used for the delivery of radiotherapy.
1. NeoSEPSIS: Consecutive hospitalized babies with neonatal sepsis will be recruited and followed up until discharge from hospital or death (for a maximum of 28 days). A minimal neonatal sepsis dataset will determine (i) clinical presentations, associated features and risk factors (for example prematurity, SGA (small for gestational age)), (ii) rates of culture-positivity among babies with sepsis, (iii) current empirical treatment approaches (antimicrobials selected, dose, etc) (iv) outcomes of sepsis, including death, need for intensive care interventions and recurrence of sepsis during the follow-up period. Microbiological samples will be taken from sterile sites, blood and CSF, as clinically indicated and will be processed locally.
2. NeoBSI: Consecutive babies with positive blood/CSF cultures and sepsis will be recruited. Patient inclusion will be based on identification of relevant specified bacteria from blood / CSF cultures. In addition to the data collected for NeoSEPSIS, information will be collected on the isolates and their antimicrobial susceptibility patterns.
Treatment consisted of gemcitabine at a dose of 1000 mg/m2, followed by cisplatin 35 mg/m2 administered on day 1 and 8, for two cycles. After that, weekly cisplatin 40mg/m2 is administered concomitant with radiotherapy (45-55Gy) in 1,8-2,0 daily fractions and a 10Gy boost when there was parametrial involvement. Low-dose rate brachytherapy, in 4 fractions of 7Gy, in a total of 28Gy will complete the protocol.
The invention relates to a novel epitope peptide of IL33 related diseases and application thereof, wherein the epitope peptide is as follows: (1) is positioned in SEQ ID NO. 1; or, (2) an amino acid sequence that is at least 80% identical to the sequence of seq id No.1 in (1). And the above-mentioned SEQ ID NO.1 contains one or more antigen epitopes, and the amino acid sequence length of the antigen epitope peptide is 2-70% of the full length of SEQ ID NO. 1. The application of the epitope peptide can comprise the preparation of vaccines or antibodies or antibody drugs and the like. The epitope peptide in the present application has immunogenicity, which can induce immune response. The epitope peptide or gene molecule, fusion protein, vector or host cell containing the epitope peptide can be used for preparing biological medicines, vaccines and the like, and has important application significance.
After the initial visit, asthmatics will be given oral prednisone for 1 week and patients will return for the spirometer assessment. Patients will be defined as CR if \<10% improvement in FEV1 % predicted is observed and as CS in \>12% improvement in FEV1% predicted is observed.