anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Benzodiazepines may cause fetal damage when administered during pregnancy. An increased risk of congenital malformations associated with the use of diazepam and chlordiazepoxide during the first trimester of pregnancy has been suggested in several studies. Transplacental distribution has resulted in neonatal CNS depression and also withdrawal phenomena following the ingestion of therapeutic doses of a benzodiazepine hypnotic during the last weeks of pregnancy.

Estazolam is contraindicated in pregnant women. If there is a likelihood of the patient becoming pregnant while receiving estazolam she should be warned of the potential risk to the fetus and instructed to discontinue the drug prior to becoming pregnant. The possibility that a woman of childbearing potential is pregnant at the time of institution of therapy should be considered.

Estazolam is contraindicated with ketoconazole and itraconazole, since these medications significantly impair oxidative metabolism mediated by CYP3A (see WARNINGS and PRECAUTIONS: Drug Interactions).
The invention provides mannase, the amino acid sequence of which comprises SEQ ID NO. 1. The mannase has the most suitable pH value of 6.0 and has higher enzyme activity at the pH value of 3.5-7.0; the pH stability is good; has good protease resistance. The high thermal stability of the material can make the material applied to industrial production requiring high temperature environment. The mannanase can be applied in feed industry to reduce or eliminate the anti-nutritional effect caused by viscosity increase. In addition, it can be used as clarifying agent for fruit juice beverage. The xylanase can also act synergistically to break bonds between hemicellulose and lignin, reduce the dosage of bleaching agents and chlorine, and further protect the environment, thereby showing great potential.
Complex polyvinyl pyrrolidones have the formula:- where R1, R2 and R3 independently are H, lower alkyl, an alkaline earth metal, m and n are 1, 2 or 3 and x is 250-300. The complex is used in pharmaceutical and cosmetic compsns. in the treatment of odontopathies and parodontopathies and in mouth hygiene. Examples are mouth washes, toothe pastes, dental water, chewing gum, pastilles, gels etc. The complex protects the teeth enamel from attack with the advantage of having the F and phosphate combined on a single support giving a stable aq. soln. The complex is prepd. by mixing solns. of the ingredients and spray drying.
Forty subjects between 18 and 60 years old, both genders, with a diagnosis of dependence on crack-cocaine, evaluated for the first time at the Center for Psychosocial Care for Alcohol and Other Drugs (CAPS-AD, in Portuguese) in the municipality of Serra, ES, Brazil, will be invited to participate in this study. After triage, following the inclusion and exclusion criteria, they will be informed in details about the experimental protocol and, if they agree to participate, it will be required to sign an Informed Consent. It Will be applied a structured anamnesis, made a psychiatric clinical and physical examination. The treatment will be started with regular medications for abstinence and comorbidities and psychosocial approaches usually done in the CAPS-AD. After selected they will be referred to the Laboratory of Cognitive Science and Neuropsychopharmacology of the Postgraduate Program in Physiological Sciences from Health Sciences Center of Federal University of Espírito Santo where they will be semi-randomly (matched for age, gender and sociodemographic characteristics) distributed into two different groups: (A) sham-tDCS (n = 20) and (B) active-tDCS (n = 20); and they will follow for 10 applications in daily sessions, excepting on weekends, of transcranial direct current stimulation (tDCS, 5 x 7 cm2, 2 mA, 20 min) over the left dorsolateral prefrontal cortex or sham procedure. Event-related potentials (ERP) will be recorded before, during and after brain stimulation or sham procedure under random presentation of three related images and three non-related images to crack use. The compulsive behavior will be evaluated before and after the ERP records. Cognitive tests which assess mental function, frontal function, visuospatial and verbal working memory, inhibition, and conflict resolution will be performed. The depression will be assessed during the treatment, and the addicted subjects will be evaluated once a week for four consecutive weeks after a series of applications of sham-tDCS or active-tDCS.
This intervention will be demonstrated during Session 1. Participants will be shown the appropriate walking intensity (low intensity; i.e., approximately 50% of maximum heart rate (220-age) or lower) by interventionist. Interventionist will observe participant engaging in walking at appropriate intensity level for 15 minutes. Walking intervention (for 15 minutes) will also be observed during Session 4 and 8.
INTRODUCTION: Although COVID-19 is mainly a respiratory disease, recent evidence has emerged of vascular and procoagulant pathologies even in young and otherwise healthy individuals. Ophthalmic manifestations include, among others, visual impairment due to arteritic and venous retinal obstructions, which at times precedes other aspects of the disease. We present two atypical cases of internal carotid dissection (ICAD) and review the different ocular symptoms of ICAD and its association with the COVID-19 pandemic.
BACKGROUND: A 43-year-old otherwise healthy man was referred to the Emergency Department with a headache and monocular blurring of vision. A recent fever (2 weeks prior) was noted on anamnesis, in light of absence of available positive PCR test during the illness period, clinical suspicion of COVID-19 was assumed. An initial ophthalmic evaluation found a mild optic nerve function impairment with preserved visual acuity. Computed tomography (CT) showed sinusitis, and an initial diagnosis was made of mild optic neuropathy secondary to sphenoid sinusitis. A few hours after admission, the patient reported deterioration of symptoms and examination revealed no light perception in his right eye and pale edematous optic nerve. Urgent magnetic resonance angiography (MRA) demonstrated right ICAD with no additional findings. The second patient, a 43-year-old man developed an acute event of strabismus, left limb paralysis, and speech difficulties while on a hospital visit for his son. The patient underwent CT of the brain which demonstrated extensive infarction following the distribution of his right cerebral artery. Continued investigation using computed tomography angiography (CTA) demonstrated a dissection of the right internal carotid artery. The patient was positive for COVID-19.
DISCUSSION: In this review, we discuss 2 cases of carotid artery dissection presenting with an acute ocular complaint in two otherwise healthy young individuals. Events were suspected to have been provoked by COVID-19 infection. The pathogenesis and mechanisms behind COVID-19 induced coagulopathy are not clear, and several mechanisms have been proposed including endothelial damage and dysfunction. The virus is thought to enter endothelial cells and lead to a pathological procoagulant state. Awareness should be drawn to uncommon signs especially in young adults. Clotting issues can arise and should be treated quickly as they might be life and vision threatening.
Placebo Intravaginal Ring A will be inserted and used for 28 days, Ring A will be removed and followed by no intravaginal ring use for 7-21 days. Then Placebo Intravaginal Ring B will be inserted and used for 28 days.
BACKGROUND: Pulmonary fibrosis (PF) is a chronic, progressive, and irreversible heterogeneous disease of lung interstitial tissue. To combat progression of PF, new drugs are required to be developed. Rhizoma coptidis (COP), one of the main alkaloids of Coptis chinensis, is a traditional herbal medicine used to treat various inflammatory diseases.
OBJECTIVE: To investigate the possible effects of Coptisine (Cop) on the growth, inflammation, as well as FMT of TNF-β1-induced HFL1 cells and uncover the mechanism.
MATERIAL AND METHODS: Human fetal lung fibroblast 1 (HFL1) was induced using 6ng/mL TGF-β1 as a model of pulmonary fibrosis. CCK-8, Brdu, and transwell assays indicated the effects on cell growth as well as motility. qPCR and the corresponding kits indicted the effects on cell inflammation. Immunoblot showed the effects on FMT and further confirmed the mechanism.
RESULTS: Coptisine inhibits excessive growth as well as motility of TNF-β1-induced HFL1 cells. It further inhibits inflammation and ROS levels in TNF-β1-induced HFL1 cells. Coptisine inhibits the FMT process of TNF-β1-induced HFL1 cells. Mechanically, coptisine promotes the Nrf2/HO-1 pathway.
CONCLUSION: Coptisine can inhibit the excessive growth, inflammation as well as FMT of lung fibroblasts into myofibroblasts. It could serve as a promising drug of PF.
PURPOSE:To modify the surface of an inorganic matter so as to be applicable to wide fields such as paints, resins, pharmaceutical preparations, cosmetics, paper, etc. by adsorbing a salt of a basic amino acid with a fatty acid on the surface and heat-treating it at a specified temp. CONSTITUTION:A salt of a basic amino acid (e.g. lysine, ornithine or alpha,gamma-diaminobutyric acid) with a 6-22C fatty acid (e.g. caproic, lauric, or stearic acid) is adsorbed on the surface of an org. matter (e.g. Kaolin, TiO2 or CaCO3) and then heat-treated at 100-250 deg.C. A dehydration-amidation reaction takes place, whereby the fatty acid salt of the basic amino acid is converted into an N-acylated basic amino acid having excellent resistance to water and solvents. Thus, the surface is modified. An inorg. matter cna be obtd. which has excellent general- purpose properties such as resistance to water and solvents and dispersibility in org. solvents. Hence, the modified product can be widely applied to various fields such as paints, resins, pharmaceutical preparations, cosmetics, paper, etc.
Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation, and the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In cancer, and particularly in the presence of oncogenic KRAS mutations, in vivo studies concluded that SG increase the resistance of cancer cells to stress. Hence, SG have recently been considered a promising target for therapy. Here, starting from our observations that genes coding for SG proteins are stimulated during development of pancreatic ductal adenocarcinoma, we analyze the formation of SG during tumorigenesis. We resort to in vitro, in vivo and in silico approaches, using mouse models, human samples and human data. Our analyses do not support that SG are formed during tumorigenesis of KRAS-driven cancers, at least that their presence is not universal, leading us to propose that caution is required before considering SG as therapeutic targets.
Individuals with acquired brain injury have reported subjective complaints of depth perception deficits, but few have undergone objective assessments to confirm these deficits. As a result, the literature currently lacks reports detailing the correlation between subjective depth perception deficits and objective stereoscopic vision deficits in individuals with acquired brain injury, particularly those cases that are characterized by a clearly defined lesion. To investigate this relationship, we recruited three individuals with acquired brain injury who experienced depth perception deficits and related difficulties in their daily lives. We had them take neurologic, ophthalmological, and neuropsychological examinations. We also had them take two types of stereoscopic vision tests: a Howard-Dolman-type stereoscopic vision test and the Topcon New Objective Stereo Test. Then, we compared the results with those of two control groups: a group with damage to the right hemisphere of the brain and a group of healthy controls. Performance on the two stereoscopic vision tests was severely impaired in the three patients. One of the patients also presented with cerebral diplopia. We identified the potential neural basis of these deficits in the cuneus and the posterior section of the superior parietal lobule, which play a role in vergence fusion and are located in the caudal region of the dorso-dorsal visual pathway, which is known to be crucial not only for visual spatial perception, but also for reaching, grasping, and making hand postures in the further course of that pathway.
Treatment with clopidogrel 50mg once daily for a minimum of 10 days (max. 14 days), followed by a minimum of 10 days treatment with clopidogrel 25mg once daily (max 14 days).
PURPOSE:To obtain a warm heat sticking agent and exothermic member tacky adhesive agent which have excellent thermal conductive and tacky adhesive characteristics, absorbs secretions such as sweat and are stable to heat by using a tacky adhesive agent consisting of an A-B-A type block copolymer, alicyclic petroleum resin, softener, and a water absorptive high polymer. CONSTITUTION:The A-B-A type block copolymer refers to a block copolymer of a monovinyl substd. arom. compd. A and conjugate diolefin copolymer B and the compounding ratio thereof is specified to 10-30 pts.wt. in the tacky adhesive agent compsn. The water absorptive polymer refers to the polymer which gelatinizes and swells by absorbing water of >=10 times its own weight and is prepd. by properly mixing 1 or >=2 kinds of the water absorptive polymers introduced with a light crosslinking bond with, for example, a water soluble polymer. The ratio of said polymer to be compounded is 1-10 pts.wt. in the tacky adhesive agent compsn. The alicyclic petroleum resin refers to a petroleum resin having cyclic skeleton and the ratio of said resin to be compounded is 10-50 pts.wt. Higher fatty acid, liquefied rubber, mineral oil, etc., are used for the softener and the ratio of the softener to be compounded is 10-50 pts.wt. The warm heat sticking agent is obtd. by combining this tacky adhesive agent with the exothermic member.
The invention discloses a traditional Chinese medicine spray for treating rhinitis and a preparation method thereof. Every 1000mL of the spray is prepared from the following traditional Chinese medicinal materials: 300-400g of prepared fructus xanthii, 200-400g of scutellaria baicalensis, 100-300g of centipeda minima, 30-100g of asarum, 100-200g of catechu, 100-300g of astragalus membranaceus and 1-15g of borneol. In the spray, fructus xanthii and asarum have the effects of promoting the restoration of consciousness, and dispelling to ascend, descend and smooth lung-qi; borneol has the effects of assisting consciousness restoration and dissipation; scutellaria baicalensis has the effects of clearing lung-heat; catechu and centipeda minima with fructus xanthii have the effects of dispersing lung-qi and regulating ascending and descending; astragalus membranaceus has the effects of tonifying qi and solidifying exterior, healing sore and promoting tissue regeneration, so that the curative effects of the medicinal materials are strong. The traditional Chinese medicine spray has the advantages that fructus xanthii, asarum and borneol can be used for promoting restoration of consciousness and relieving symptoms, fructus xanthii and scutellaria baicalensis are used for sterilizing, and astragalus membranaceus is used for repairing injured nasal mucosa and improving immunity, so that the effects of eliminating pathogen, strengthening vital qi and treating both symptoms and root causes can be achieved. Furthermore, the spray also comprises a solubilizer, a preservative and a thickening agent, is convenient to use, can directly reach the acting position, and has high dispersion degree to improve the curative effect. The spray can be used for treating chronic rhinitis, allergic rhinitis and acute rhinitis, and especially has a remarkable curative effect for chronic rhinitis.
Chronic graft-versus-host disease (cGVHD) is a long-term complication of allogeneic hematopoietic stem cell transplantation associated with poor quality of life and increased morbidity and mortality. Currently, there are several approved treatments for patients who do not respond to steroids, such as ruxolitinib. Nevertheless, a significant proportion of patients fail second-line treatment, indicating the need for novel approaches. Mesenchymal stem cells (MSCs) have been considered a potential treatment approach for steroid-refractory cGVHD. To evaluate the safety and efficacy of repeated infusions of MSCs, we administered intravenous MSCs every two weeks to ten patients with severe steroid-refractory cGVHD in a prospective phase I clinical trial. Each patient received a total of four doses, with each dose containing 1 × 106 cells/kg body weight from the same donor and same passage. Patients were assessed for their response to treatment using the 2014 National Institutes of Health (NIH) response criteria during each visit. Ten patients with diverse organ involvement were enrolled, collectively undergoing 40 infusions as planned. Remarkably, the MSC infusions were well tolerated without severe adverse events. Eight weeks after the initial MSC infusion, all ten patients showed partial responses characterized by the amelioration of clinical symptoms and enhancement of their quality of life. The overall response rate was 60%, with a complete response rate of 20% and a partial response (PR) rate of 40% at the last follow-up. Overall survival was 80%, with a median follow-up of 381 days. Two patients died due to relapse of their primary disease. Immunological analyses revealed a reduction in inflammatory markers, including Suppression of Tumorigenicity 2 (ST2), C-X-C motif chemokine ligand (CXCL)10, and Secreted phosphoprotein 1(SPP1), following the MSC treatment. Repeated MSC infusions proved to be both feasible and safe, and they may be an effective salvage therapy in patients with steroid-refractory cGVHD. Further large-scale clinical studies with long-term follow-up are needed in the future to determine the role of MSCs in cGVHD.
Patients and their partners receive an exercise plan and printed materials that includes instructions for walking or other moderate-intensity activities. Patients and their partners also receive coaching calls discussing physical activity and diet related questions, each lasting 45-60 minutes and occurring every 2 weeks for 6 months. In addition, patients and their partners complete 2 nutrition counseling sessions over 1 hour each at baseline and before month 3 with an MD Anderson registered dietitian.
PROBLEM TO BE SOLVED: To reduce its storage capacity when ultrasonic image data are recorded in an external device in an ultrasonograph. SOLUTION: The first brightness signal Y1 is outputted as a signal corresponding to a B mode image from a detector 14 and on the other hand, the second brightness signal Y2 corresponding to a color Doppler image and two color difference signals R-Y2 and B-Y2 are outputted from a color coding tool 22. In a converter 26, the first brightness signal Y1 and the second brightness signal Y2 are added. Informations on a formed synthesized brightness signal and two color difference signals R-Y2 and B-Y2 can be outputted thereby to an external device through an encoder 32 or the informations can be inputted from the external device like this through a decoder 36. Various output terminals and input terminals are provided in the apparatus main body.  As not an RGB system but a signal embodiment based on a Y/color difference system is used for inputting image data, capacity of the data can be reduced without generating deterioration of the quality of the image.
The invention belongs to the technical field of biological medicines, and particularly relates to an siRNA for inhibiting circATF IP gene expression, a delivery system and application thereof. An siRNA for inhibiting circATF IP gene expression, said siRNA having a sense strand and an antisense strand, the nucleotide sequence of said sense strand comprising a modified or unmodified nucleotide sequence as set forth in SEQ ID No. 1; the nucleotide sequence of the antisense strand comprises a modified or unmodified nucleotide sequence shown as SEQ ID NO. 2. The invention can obviously inhibit circATF IP gene expression in the brain, blood and liver of mice by injecting 3 times of medicaments to mice through nasal administration aiming at the siRNA expressed by circATF IP target genes. Meanwhile, the delivery system for delivering circATF IP can be used as circATF IP inhibitor, can be prepared into medicines with one or more pharmaceutically acceptable auxiliary materials, and is applied to treating indications related to circATF IP gene expression, such as cardiovascular diseases, neurodegenerative diseases, cancers, autoimmune diseases and the like.
A responder will correspond to a decrease in abdominal pain score (11-points NRS pain) of at least 30% compared to the score before treatment and a score of 6 or 7 on the SGA scale. At endpoint (12-weeks treatment period), it will be compared the responder rate between the 2 treatment arms (ethosuximide vs placebo).
INTRODUCTION/AIMS: In Guillain-Barré syndrome (GBS), patients with dysautonomia demonstrate sympathetic overactivity (SO). This study assessed the role of prazosin (α1-blocker) in the management of SO.
METHODS: This cohort study was conducted from January 2022 to September 2023. Thirty-two GBS patients with SO received prazosin (2.5-10 mg three times a day) (prazosin group). For comparison, we included historical controls that included 33 GBS patients having SO with similar baseline characteristics, including median age and disability, who did not receive prazosin, from a GBS registry of patients admitted during February 2018-December 2021. The primary endpoint was days to resolution of SO. Secondary endpoints were daily fluctuations in the systolic (SBP) and diastolic blood pressure (DBP), duration of hospital stay, in-hospital mortality, and disability at 3 months.
RESULTS: The median ages of both the treatment and the control groups were 36 (IQR 25-49) years and 43 (66.2%) were males. The demographic and clinical parameters were comparable. Prazosin resulted in significantly earlier normalization of SO compared to the control group (median 15 vs. 20 days; p = .01). The mean fluctuations in the SBP and DBP at 15 days were significantly lower in the prazosin group. However, the duration of hospital stay and good recovery at 3 months were comparable. Three patients developed hypotension, while two patients died (ventilator-associated pneumonia) in the prazosin group.
DISCUSSION: This study provides new evidence supporting the role of prazosin in SO, and needs randomized trials to confirm our findings.