anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
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  * Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. (5.1)
  * Diclofenac sodium is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. (4, 5.1)
  * NSAIDs, cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and or GI bleeding are at greater risk for serious GI events. (5.2)
The intervention is made up of 14 internet modules based on behavioral activation, cognitive behavioral therapy, and interpersonal psychotherapy as well as motivational interviews in the primary care setting (to enhance behavior change). It is suggested that an adolescent navigates through 2 modules a week. The motivational interviews with the physicians occur directly before and after the adolescent is exposed to the website (at baseline and 3 months) in the providers office. The parents of the enrolled adolescents are also invited to navigate through their own, 3 module, parent internet program.
Systems, methods, and computer program products are provided that can facilitate providing secure, on-line communications between healthcare providers and remotely located patients. Patients, during on-line virtual office visits, provide various information about one or more medical conditions in a predetermined, structured format. Patients are assigned to pools of patients based upon one or more patient attributes and/or one or more healthcare provider attributes. A healthcare provider qualified to treat patients in the pool selects a patient from a displayed list and views the medical condition of the patient. The physician prepares a diagnosis and/or treatment recommendation for the medical condition(s) of the patient and sends a communication containing the same to a secure area. The patient is then notified of the physician's communication and is directed to log-on to the secure area and view the communication.
BACKGROUND: The systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state and immune response. Psoriasis is an immune-mediated disease notable for its chronic inflammation of the entire system. Our research sought to explore the latent link between psoriasis and SII.
METHODS: We performed a cross-sectional investigation utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES, 2009-2014). Employing multivariate linear regression models and subgroup analysis, we sought to uncover the association between SII and psoriasis.
RESULTS: This study enrolled a total of 17,913 participants as part of its research cohort. Our multivariate linear regression analysis revealed a notable and positive correlation between SII and psoriasis [1.013 (1.000, 1.026)]. As SII tertiles increased, the risk of psoriasis demonstrated an upward trend. The significant dependence on this positive association were maintained in women, BMI(≥ 30 kg/m2),non-stroke and non-cancer subjects in subgroup analysis and interaction tests. Furthermore, we identified a significant association between SII and psoriasis, characterized by two consecutive inverted U-shaped patterns. Notably, the analysis revealed the most prominent inflection point at a specific value of 797.067.
CONCLUSIONS: The results indicate a significant correlation between elevated SII levels and the presence of psoriasis. However, to corroborate and strengthen these results, additional large-scale prospective studies are required.
The present disclosure provides a transfersome including extracts of Garcinia mangostana prepared by the following steps. A first solution is provided, wherein the first solution is used as a water phase and includes an extract of Garcinia mangostana. A second solution is provided, wherein the second solution is used as an oil phase and includes a lecithin and a surfactant, and the lecithin and the surfactant are contained in a volume ration of 1:1 to 4:1. An emulsification is performed, wherein the emulsification mixes the first solution and the second solution so as to obtain an emulsion. A homogenization step is performed, wherein the homogenization step vortexes the emulsion so as to obtain the transfersome including extracts of Garcinia mangostana. Therefore, the transfersome including extracts of Garcinia mangostana of the present disclosure can carry the extracts of Garcinia mangostana effectively and transfer in the tissue of organisms and has a marketing potential in the related fields.
Subjects in control group are treated NRT and counselling. Nicotine Replacement Therapy is provided 7 patches and 30 gums once a week for 4 weeks. Using amounts are depend on each subject's cravings. (Investigator will check how much they used.) Doctor consults about 10-15 minutes per visit.

Subjects in intervention group are treated NRT, counselling and traditional \& complementary medicine treatment (Body acupuncture, Ear acupuncture and aromatic therapy). Body acupoints are HT7, LI4, ST36, LU7, LU6 on both sides. Ear acupoints are Shenmen, Lung, Pharynx, Trachea, Endocrine. Subjects are treated with acupuncture for 20 minutes per visit and put ear acupuncture like sticker for 1-2 days. Mixture oil of Lavender, peppermint, rosemary are used to massage behind the ears. It is used 2 times a day and they can adjust frequency depending on their cravings.(Investigator will check how much they used.)
Post-traumatic stress disorder (PTSD) is a type of anxiety disorder affecting people who have witnessed or experienced a traumatic event. Veterans of war are at an increased risk for developing PTSD because of their experiences with war and combat. Symptoms of PTSD often include flashbacks or nightmares, depression, anxiety or uneasiness, and feeling emotionally numb or distant toward others. Fortunately, PTSD can be treated, usually with some combination of anti-depressants, anti-anxiety medication, and therapy. Virtual reality exposure (VRE) therapy is a new type of treatment that helps people to overcome anxiety about trauma by facing situations with the use of virtual reality. D-cycloserine is a medication that has been found to enhance the effects of psychotherapy in recent studies. This study will determine the effectiveness of VRE therapy plus D-cycloserine at reducing PTSD symptoms in Iraq war veterans.

During this study, all participants will undergo one educational session and five VRE sessions. The first session will involve gathering information, learning common reactions to trauma, and participating in a breathing relaxation approach. The following five sessions will involve reviewing memories of Iraq and watching virtual Iraq sequences. Each participant will wear a head-mounted display during which they will view scenario settings such as cities, humvee convoys, and scenes related to combat. Participants will be randomly assigned to receive D-cycloserine, alprazolam (anti-anxiety drug), or placebo one half-hour before each VRE session.

Prior to the first treatment session, participants will undergo a startle reaction procedure. This will entail hearing sudden tones that last a fraction of a second, and viewing virtual reality scenes. Three small electrodes, attached to each participant's face, will measure the number of eye blinks during the procedure. At several times throughout the study, heart rate and skin conductance will also be measured with electrodes. Collection of saliva samples and measurement of blood pressure will also occur several times during this study. Before, during, and immediately after treatment, participants will complete questionnaires. Participants will be contacted 3, 6, and 12 months after treatment to assess symptoms and to schedule a time for an interview, additional questionnaires, and the virtual reality-based assessment.
PURPOSE:To provide a plaster material useful for plaster preparation, etc., having a tacky adhesive layer composed of a cross-linked polymer on the surface of a substrate, exhibiting an adhesiveness falling within a specific range, smoothly peelable without causing pain and exhibiting the adhesiveness, plastering property and adhesive property over a long period. CONSTITUTION:A tacky adhesive composition composed of 100 pts.wt. of an acrylic polymer, 25-200 pts.wt. of a liquid component compatible with the polymer, e.g. a glycerol ester and 0.05-1.0 pt.wt. of a cross, linking agent is applied in an amount of preferably 8-20g/m<2> to a surface of a substrate such as a polyester film and the coating film is crosslinked to obtain a tacky adhesive layer. The adhesiveness of the tacky adhesive layer is 20-180g/12mm width, preferably 40-150g/12mm width measured by attaching the tacky adhesive faces to each other and peeling at a definite speed at a peeling angle of 180 deg.. A plaster preparation is obtained by incorporating 1-40wt.% of an agent to 100 pts.wt. of the tacky adhesive composition.
Teratogenic Effects:  
  
There are no adequate and well controlled studies of metronidazole in pregnant women. There are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than 5000 pregnant women who used metronidazole during pregnancy. Many studies included first trimester exposures. One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to metronidazole in-utero; however, these findings were not confirmed. In addition, more than ten randomized placebo-controlled clinical trials enrolled more than 5000 pregnant women to assess the use of antibiotic treatment (including metronidazole) for bacterial vaginosis on the incidence of preterm delivery. Most studies did not show an increased risk for congenital anomalies or other adverse fetal outcomes following metronidazole exposure during pregnancy. Three studies conducted to assess the risk of infant cancer following metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited.  
  
Metronidazole crosses the placental barrier and its effects on the human fetal organogenesis are not known. Reproduction studies have been performed in rats, rabbits, and mice at doses similar to the maximum recommended human dose based on body surface area comparisons. There was no evidence of harm to the fetus due to metronidazole.
PURPOSE: Atherosclerotic cervical internal carotid artery disease is one of the major causes of ischemic stroke and transient ischemic attacks. The risk of stroke from mild to moderate stenoses (i.e. <50% stenosis) might be underestimated. There is increasing evidence that plaque morphological features reflect plaque instability that may harbor high risk for embolization. In this narrative review, we will review the literature on plaque features that predict vulnerability beyond the degree of stenosis, discuss the clinical association with stroke, and evaluate the evidence that these lesions serve as a source for embolic stroke of unknown source (ESUS).
METHODS: We performed a literature search using PubMed, EMBASE, and Web of Science. The terms "embolic stroke of undetermined source" and "plaque morphology" were used either alone or in combination with "non-flow limiting stenosis," "non-stenosing plaques," "high-risk plaque features" or "internal carotid artery plaque." Data on plaque morphology and ESUS were mainly taken from review articles, observational studies including retrospective cohort and cross-sectional studies, meta-analyses, and systematic reviews.
CONCLUSION: Nonstenosing carotid artery plaques with high-risk features carry a remarkable risk for stroke occurrence and randomized clinical trials are warranted for further evaluation of using carotid artery stenting or carotid endarterectomy to mitigate the risk of stroke.
Malignant pericardial mesothelioma (MPM) is extremely rare, and peritoneal dissemination has not yet been reported. There is no consensus regarding appropriate pharmacological treatment for MPM, including immune checkpoint inhibitors (ICIs). We herein report a 36-year-old man with MPM diagnosed by peritoneal dissemination and treated with an ICI. Cytology of the ascites revealed malignant peritonitis, and a re-evaluation of a pericardial biopsy performed at the previous hospital led to a diagnosis of MPM. The patient was treated with nivolumab and showed a clinical response despite several complications, such as renal dysfunction and performance status deterioration. This case report provides suggestive information for the diagnosis and ICI therapy of a rare type of mesothelioma.
Recent literature provides substantial evidence supporting the efficacy of muscle energy techniques (METs), including Autogenic Inhibition, for various musculoskeletal conditions across different populations. Robert F. et al. (2023) conducted a quasi-experimental study using a pre- and post-test design to compare Kalternborn grade III mobilization and METs in 30 patients, finding significant improvements in pain and neck function. Siddiqui M. et al. (2022) demonstrated in a randomized control trial that Autogenic Inhibition was more effective than Reciprocal Inhibition in improving pain, range of motion, and functional disability in patients with mechanical neck pain. Similarly, Osama M. et al. (2022) found Autogenic Inhibition to be the most effective among static stretching, AI-MET, and RI-MET for enhancing isometric muscle strength in neck pain patients. Majeed A. et al. (2021) showed that Autogenic Inhibition had better outcomes than static stretching for hamstring flexibility. Khaled H. Yousef et al. revealed that adding METs to conventional therapy significantly improved pain, impairment, and hip range of motion in patients with chronic discogenic sciatica. A systemic review by Thomas E. et al. (2019) confirmed METs' effectiveness in reducing chronic and acute pain and improving range of motion. Despite these positive findings, there is limited research on METs for sports-related conditions like shin splints. This study aims to fill this gap by examining the specific benefits and drawbacks of a structured MET program for shin splints in a sports environment, providing valuable insights for athletes in managing and preventing overuse and bone stress injuries efficiently.
All childcare centers enrolled to Aim 1 will be observed. The physical activity environment will be examined before and after the implementation of playground stencils.
In order to determine eligibility, a brief phone screen lasting approximately 15 minutes will be conducted. If participants are eligible, they will be asked to come in for three separate visits. During the first visit, participants will complete questionnaires as well as a structured interview with one of the study's staff members at Palo Alto University in Los Altos. During the second visit, participants would come to Palo Alto University in Los Altos and complete questionnaires as well as a testing session involving various tasks. During the third visit, participants would undergo a non-invasive brain scan in which participants would complete a task as well as various questionnaires at Stanford University in Stanford.

The investigators have flexible hours and can work around participants' schedules! To inquire more about participation, participants can either email the investigators at paloalto.study@gmail.com or call the investigators at (650) 417-2000 ext. 3642
An oral contraceptive pill (Microgynon30®, Bayer Hispania, Spain) was taken for a maximum of 21 days, starting on day 1-2 of the menses of the previous cycle. After a wash-period of five days after the last pill, donors started to receive daily doses of 150-300 UI of urinary FSH (uFSH) (Fostipur®, Angelini, Spain; n=30) depending on their age, body mass index (BMI) and ovarian response in previous cycles. Daily doses of 0.25 mg gonadotropin- releasing hormone antagonist cetrorelix (Cetrotide®, Merck-Serono, Spain) were started on day six of stimulation in each group. When at least three or more leading follicles reached a mean diameter of ≥18 mm, hCG (Ovitrelle®, 250 µg; Merck-Serono, Spain) was administered subcutaneously.
Human chronic diseases thought to have an immunological etiology are associated with particular changes in the gut microbiota. While bacterial profiles may be a consequence of the disease state, animal fecal transfer experiments suggest that disease predisposition can be transferred along with the microbiota. Diet can influence bacterial genome composition and may modulate disease predisposition via this mechanism. Disclosed are specific genotypes derived from human Complement Factor H (CFH) and ARMS2 gene SNPs that are associated with characteristic microbiome composition in humans. These polymorphisms are associated with diseases of human aging such as Alzheimer disease and age-related macular degeneration.  Specific secondary prophylactic measures that affect the course of these diseases alter the gut microbiota and ameliorate genotype-specific, disease-associated changes.  Personalized therapy for individuals with Alzheimer disease and age-related macular degeneration are selected based on observed interactions of the microbiota and CFH and ARMS2 genotypes.
Globally, many children and adolescents are insufficiently physically active which increases the prevalence of non-communicable diseases and poor mental health over the lifecourse. Schools are an important setting to promote physical activity (PA) as children and adolescents spend a large proportion of their waking hours in this setting. The MOVEOUT study aims to increase school-based PA and wellbeing trough implementing regular practice of education outside the classroom (EOtC) during school hours. In EOtC, teachers relocate teaching and learning activities to places and settings outside the school building, e.g., urban and green space, societal institutions, and private companies, in agreement with curricular aims, content and obligations. The aim of EOtC is to promote pupils' learning and wellbeing through practical activities and the use of body and senses in authentic situations. Cross-sectional studies suggest that practice of EOtC is positively associated with more moderate-to-vigorous PA for boys, and more and light-intensity PA for girls. Quasi-experimental studies further demonstrate a positive effect of regular practice of EOtC on school motivation and wellbeing, without compromising academic performance. However, no studies have investigated the effect of EOtC on PA, school motivation, or wellbeing in a randomised controlled design. Furthermore, the specific pedagogical and didactical elements in EOtC sessions that promote PA, school motivation, and wellbeing have not been researched. Therefore, the aim of MOVEOUT is to study the effect on adolescents' PA, school motivation, and wellbeing and the mechanisms of EOtC that might promote PA, school motivation, and wellbeing in a randomised controlled design.

Compared to previous studies, the MOVEOUT study provides a methodologically improved and more robust evaluation. This study investigates the efficacy, mechanisms, and mediating effects of an EOtC intervention, The TEACHOUT Intervention\[1\], in a cluster randomised waitlist controlled trial with 15 intervention schools and 15 control schools. Schools will be required to have one or more classes grade 4-10 (pupils aged 10-16). The study will investigate which pedagogical and didactical elements of EOtC that are important to achieve more PA, school motivation, and wellbeing for 1) all adolescents, 2) adolescents at risk of becoming overweight, and 3) boys and girls separately. MOVEOUT will provide solid evidence of the effect of EOtC and supplement theory on EOtC pedagogy and didactics, which is needed in practice and policy to inform the already ongoing scale-up of EOtC, for instance in Northern European countries. The study is conducted in partnership between the applying institutions and the participating schools through all phases.
The present disclosure provides novel Fe(III)-complexes according to Chemical Formula (I):as well as enantiomers (and diastereomers) and solvates thereof. In Chemical Formula (I), Z is selected from O, NH and NR, wherein R is a branched or linear C1-C15 alkyl. R<sup>1</sup> is C1-C15 alkyl. Further, the orientation of the amine groups of the cyclohexyl ring in Chemical Formula (I) defines a trans-isomer. A further aspect of the disclosure refers to a contrast agent for magnet resonance imaging, which includes the Fe(III)-complex according to the present disclosure. In addition, the present disclosure provides novel ligands according to Chemical Formula (II), as well as (diastereomers and) enantiomers thereof, which constitute intermediate products for preparation of prespecified Fe(III)-complexes.
PROBLEM TO BE SOLVED: To reduce the deterioration or the photoactivity of cosmetic, coating material and plastic caused by ultraviolet ray by specifying the number average particle diameter range of a primary particle and the half-value width range of angle of diffraction in X-ray diffraction to improve ultraviolet shielding property. SOLUTION: In a powder of cerium oxide, the number average particle diameter of the primary particle is controlled to 0.01-0.5 μm. If the particle diameter is below the lower limit, the probability of light transmission is increased to make the shielding property insufficient though the number of the particle is increased and if the particle diameter exceeds the upper limit, the number of the particle is decreased to make the shielding property insufficient though light is not transmitted to be scattered. And the half-value width 2δ (degree) of 28.6 deg. angle of diffraction (111 plane) in the X-ray diffraction is 0.7-0.15. In the range where the half-value width exceeds the upper limit, the crystallinity becomes insufficient to be nearly amorphous and in the range below the lower limit, the particle is over grown and in both case, ultraviolet ray is easily transmitted.  The cerium oxide is blended to the coating material or the cosmetic in the form as the particle is and can be also blended in a paste-like or slurry like form.
BACKGROUND: This study aims to investigate prognostic implications of coronary slow flow (CSF) and angiography-derived index of microcirculatory resistance (caIMR) in patients with angina and normal coronary arteries.
METHODS: A total of 582 patients were enrolled with angiographically normal coronary arteries. caIMR was calculated using a commercial software. Patients were followed up for a median of 45 months. The primary endpoint was defined as major adverse cardiovascular events (MACEs) comprising death, myocardial infarction and readmission for angina or heart failure.
RESULTS: CSF was diagnosed when TIMI grade 2 flow presented in at least one coronary artery. Multivariate analysis indicated TIMI-flow-based determination of CSF was not significantly associated with MACEs [hazard ratio (HR): 2.14; 95% confidence interval (CI): 0.87-5.31; p = 0.099), while caIMR >42 (HR: 2.53; 95% CI: 1.02-6.32; p = 0.047) were independent predictors of MACEs. Incorporation of caIMR improved the area under the curve from 0.587 to 0.642.
CONCLUSIONS: caIMR was an independent prognostic factor of long-term cardiovascular events in patients with CSF. Evaluation of caIMR improved the risk stratification of patients with angiographically-normal coronary arteries.