anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: It is well known that socially deprived children are more likely to be hospitalised for infections. Less is known about how different social disadvantages interact. Therefore, we examine intersectional inequalities in overall, upper respiratory, lower respiratory, enteric and genitourinary infections in the first 5 years of life.
METHODS: We conducted a population-based retrospective cohort study of Swedish children born between 1998 and 2015. Inequalities were examined using analysis of individual heterogeneity and discriminatory accuracy as the analytical framework. A variable with 60 intersectional strata was created by combining information on maternal education, household income, sex/gender and maternal migration status. We estimated the incidence rates of infectious disease hospitalisation for each intersectional strata and the associations between intersectional strata and infectious disease hospitalisations using logistic regression models. We furthermore quantified the discriminatory ability of the intersectional strata with respect to infectious disease hospitalisation.
RESULTS: The study included 1785 588 children and 318 080 hospital admissions. The highest overall incidence of hospitalisations for infections was found in boys born to low-educated mothers who lived in families with the lowest household income. The overall incidence of infections was unrelated to household income in children born to highly educated mothers. The ability of the intersectional strata to discriminate between children with and without infections was poor.
CONCLUSION: We found that inequalities in paediatric infectious diseases were shaped by the intersections of different social disadvantages. These inequalities should be addressed by public health policies that reach all children.
Evidence on cash transfers as a population-level intervention to support healthy cognitive aging in low-income settings is sparse. We assessed the effect of a cash transfer intervention on cognitive aging outcomes in older South African adults. We leveraged the overlap in the sampling frames of a Phase 3 randomized cash transfer trial [HIV Prevention Trial Network (HPTN) 068, 2011-2015] and an aging cohort [Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community (HAALSI), 2014-2022] in rural Mpumalanga Province, South Africa. In 2011/12, young women and their primary caregivers were randomly assigned 1:1 to receive a monthly cash transfer or control. In 2014/2015, 862 adults aged 40+ y living in trial households were enrolled in the HAALSI cohort, with cognitive data collected in three waves over 7 y. We estimated the impact of the intervention on rate of memory decline and dementia probability scores. Memory decline in the cash transfer arm was 0.03 SD units (95% CI: 0.002, 0.05) slower per year than in the control arm. Dementia probability scores were three percentage points lower in the cash transfer arm than the control arm (β = -0.03; 95% CI: -0.05, -0.001). Effects were consistent across subgroups. A modestly sized household cash transfer delivered over a short period in mid- to later-life led to a meaningful slowing of memory decline and reduction in dementia probability 7 y later. Cash transfer programs could help stem the tide of new dementia cases in economically vulnerable populations in the coming decades.
Hypoxic-ischemic brain damage (HIBD) is a cerebral injury resulting from the combination of ischemia and hypoxia in neonatal brain tissue. Presently, there exists no efficacious remedy for HIBD. A mounting body of evidence indicates that dynamic metabolites formed during metabolic procedures assume a vital role in neuronal maturation and recuperation. However, it remains unclear whether any endogenous metabolites are involved in the pathogenesis of HIBD. Here, an untargeted metabolomics analysis was conducted by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry (GC/LC-MS) in OGD/R (oxygen-glucose deprivation/reoxygenation)-induced HT-22 cells. We observed that ferroptosis signaling plays an essential role in HI-induced neuronal injury. Interestingly, we also found that the differentially expressed metabolite, 2-phosphoglyceric acid, significantly improved the neuronal cell survival of OGD/R HT-22 cells by inhibiting ferroptosis. Moreover, 2-phosphoglyceric acid effectively rescued the cell activity of HT-22 cells treated with the ferroptosis inducer RSL-3. Furthermore, 2-phosphoglyceric acid alleviated cerebral infarction and reduced HIBD-induced neuronal cell loss of the central nervous system in neonatal rats by regulating GPX4 expression. Taken together, we found that 2-phosphoglyceric acid, which was downregulated in HT-22 cells induced by OGD/R, exerted neuronal protective effects on OGD/R-treated HT-22 cells and HIBD-induced neonatal rats by inhibiting hypoxic-ischemic-induced ferroptosis through the regulation of the GPX4/ACSL4 axis.
PROBLEM TO BE SOLVED: To obtain the subject promoter having tyrosinase activity promoting effect and useful for e.g. a gray hair preventive agent by formulating a Japanese pepper (Zanthoxylum piperitum) extract as active ingredient. SOLUTION: This tyrosinase activity promoter is obtained by formulating, as active ingredient, 0.0001-10.0 (pref. 0.0005-5.0) wt.% of a Japanese pepper extract (pref. a lower alcohol (e.g. methanol) extract).
Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma (SCC) characterized by its histological presentation as a low-grade tumor with no potential for metastasis, setting it apart from invasive SCC. However, distinguishing VC from its benign counterpart, verrucous hyperplasia (VH), is challenging due to their clinical and morphological similarities. Despite the importance of accurate diagnosis for determining treatment strategies, diagnosis of VH and VC relied only on lesion recurrence after resection. To address this challenge, we generated RNA profiling data from tissue samples of VH and VC patients to identify novel diagnostic markers. We analyzed differentially expressed (DE) mRNA and long non-coding RNA (lncRNA) in tissue samples from VH and VC patients. Additionally, ChIP-X Enrichment Analysis 3 (ChEA3) was conducted to identify the top five transcription factors potentially regulating the expression of DE mRNAs in VH and VC. Our analysis of mRNA and lncRNA expression profiles in VH and VC provides insights into the underlying molecular characteristics of these diseases and offers potential new diagnostic markers. The identification of specific DE genes and lncRNAs may enable clinicians to more accurately differentiate between VH and VC, leading to better treatment choices.
Acupressure will be applied to the elderly in the experimental group once a day, 5 days a week (Monday-Friday) for a week. The application will last for 2 weeks. A total of 10 sessions of acupressure will be applied. Acupressure application will be applied by researchers who have been trained and certified on this subject. While the elderly are in supine position, pressure will be applied to each acupressure point, respectively, Tianshu (ST25), Guanyuan (CV4) and Hegu (LI4) for 2 minutes for a total of 6 minutes.
The treatment of facial abscesses of dental origin is difficult as jaw osteomyelitis in rabbits is mainly associated with a thick caseous pus that is particularly difficult to drain. Precise identification of the teeth involved in the infected site with the use of cone beam computed tomography (CBCT) was expected to ensure a favorable surgical treatment plan without a long-term local antibiotic strategy or local marsupialization. The first part of the study compared multi-planar reconstruction (MPR) and 3D reconstruction complemented by a maximum intensity projection filter (MIP). The surgical part of the study included rabbits with documentation of the treatment outcome for a period greater than one month after surgery and having had at least one post-operative CBCT demonstrating the achievement of surgical extraction. MPR is significantly more efficient than MIP techniques for alveolar bone (P < 10-7), spongious bone (P < 10-10) and apical elongation (P < 10-5) parameters. Nineteen of 20 surgical sites gave radiological confirmation of the success of the surgical plan. Eighteen of 20 of the abscess sites were clinically healed within one month. Seven out of 20 of the abscess sites presented evidence of one dental structure regrowth following the CBCT recheck. Two out of these seven cases presented with a concomitant persistent chronic facial fistula. Both cases healed after second-stage surgery to extract the tooth structure. The mean number of teeth extracted was 2.85, and seven of the 20 procedures included one incisor.
Heterozygous RTN2 variants have been previously identified in a limited cohort of families affected by autosomal dominant spastic paraplegia (SPG12-OMIM:604805) with a variable age of onset. Nevertheless, the definitive validity of SPG12 remains to be confidently confirmed due to the scarcity of supporting evidence. In this study, we identified and validated seven novel or ultra-rare homozygous loss-of-function RTN2 variants in 14 individuals from seven consanguineous families with distal hereditary motor neuropathy (dHMN) using exome, genome and Sanger sequencing coupled with deep-phenotyping. All affected individuals (seven males and seven females, aged 9-50 years) exhibited weakness in the distal upper and lower limbs, lower limb spasticity and hyperreflexia, with onset in the first decade of life. Nerve conduction studies revealed axonal motor neuropathy with neurogenic changes in the electromyography. Despite a slowly progressive disease course, all patients remained ambulatory over a mean disease duration of 19.71 ± 13.70 years. Characterization of Caenorhabditis elegans RTN2 homologous loss-of-function variants demonstrated morphological and behavioural differences compared with the parental strain. Treatment of the mutant with an endoplasmic/sarcoplasmic reticulum Ca2+ reuptake inhibitor (2,5-di-tert-butylhydroquinone) rescued key phenotypic differences, suggesting a potential therapeutic benefit for RTN2-disorder. Despite RTN2 being an endoplasmic reticulum (ER)-resident membrane shaping protein, our analysis of patient fibroblast cells did not find significant alterations in ER structure or the response to ER stress. Our findings delineate a distinct form of autosomal recessive dHMN with pyramidal features associated with RTN2 deficiency. This phenotype shares similarities with SIGMAR1-related dHMN and Silver-like syndromes, providing valuable insights into the clinical spectrum and potential therapeutic strategies for RTN2-related dHMN.
PURPOSE: A cosmetic composition for reliving skin trouble is provided to suppress prostaglandin E2 generation and to erythema and to relieve cytotoxicity and skin irritation. CONSTITUTION: A cosmetic composition for relieving skin trouble contains mixture extract of Sparassis crispa, Agaricus blazeii, and Polyporus umbellatus. A cosmetic composition for anti-inflammation contains the mixture extract. A cosmetic composition for suppressing erythema due to UV ray contains the mixture extract. The cosmetic compositions contains 0.1-20 weight% of mixture extract. The cosmetic compositions are manufactured in the form of skin softener, skin toner, astringent, lotion, milk lotion, essence, pack, soap, shampoo, cleansing cream, and body cleanser.
A material and method are disclosed facilitating the forming of impressions of teeth and/or supporting structures, such as the alveolar ridge to be duplicated and restored. An elastomeric impression material, preferably subject to photochemical or chemical curing, is provided, such for example as formed from polyesters, polyethers, polysulfides, silicones, and ethylene imines, or derivatives thereof, containing a filler material, such as talc, calcium carbonate, colloidal silica, glass, quartz, acrylates, etc., and impregnated with a hemostatic agent such as a vasoconstrictor or astringent or the like with the impression material serving to maintain subgingival tissue in a retracted condition without bleeding, so as to permit an impression to be taken of a tooth surface area and volume extending below the gumline, without requiring use of gum retracting cords or bands. In use, a portion of the impression material in a cord, ring or rhomboid shape, or the like, is wedged between the gum and the tooth to conform to the contour of the tooth below the gum and cured by chemical or photochemical means. This procedure is followed by the taking of an impression material adhering to the impression material below the gum, thereby providing an exact duplication of the tooth, both above and below the gum. The impression materials may be color-coded to delineate soft from hard tissue. By making the impression material photochemically or chemically curable the time for the procedure may be controlled, and the dentist may reline dentures without the need for laboratory work, and use it in other ways not limiting it to those mentioned.
<P>PROBLEM TO BE SOLVED: To provide a hairdressing cosmetic usable for consumers worrying about their thin hair in a sense of a hairdressing preparation, easily giving the whole hair firmness or firm texture, and affording the hair with voluminous feeling or hair-increased feeling to look at.  <P>SOLUTION: This hairdressing cosmetic contains solid resin fibers and a water-soluble resin. The cosmetic works as follows: The solid resin fibers are made to adhere to the hair followed by coating the resultant hair with the water-soluble resin, thus enabling the whole hair to be easily afforded with firmness or firm texture, affording the hair with voluminous feeling or hair-increased feeling to look at. In this cosmetic, the solid resin fibers are preferably one or more kinds selected from nylon fibers, rayon fibers, tetrafluoroethylene resin fibers, perfluoroalkoxy resin fibers, fluoroethylene-propylene resin fibers, cellulose fibers, wool fibers and hemp fibers. In particular, this cosmetic is preferably a gel-like one in terms of its use.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The invention discloses application of miRNA to diagnosis and treatment of acute myelogenous leukemia. The miRNA is miRNA-1277. Whether a patient has the acute myelogenous leukemia or not can be diagnosed through detecting the expression level of the miRNA-1277. Experiments prove that the expression level of the miRNA-1277 in the patient with the acute myelogenous leukemia is obviously lower than that of healthy people. On the basis, the miRNA-1277 can also be used for preparing medicine for treating the acute myelogenous leukemia. The sensitivity and the specificity of the diagnosis of the acute myelogenous leukemia are greatly improved; meanwhile, a new target point is provided for gene treatment of the acute myelogenous leukemia.
The treatment group will wear a Fitbit step counter for 8 weeks. In addition, participants will use the full version of the Go\&Grow fitness app for 6 weeks.
PCD is a rare genetic disorder in which impaired mucus clearance commonly results in chronic cough and infections in the airways, sinuses, and middle ears. Long lasting airway infection ultimately leads to structural damage to the airways, known as bronchiectasis, and, in turn, loss of lung function. While PCD shares some similarities with the disease cystic fibrosis, it is important to distinguish PCD from cystic fibrosis. In particular, the age of onset and progression of PCD's clinical lung disease, including timing of specific microbial pathogen infections and bronchiectasis, remain poorly defined. The purpose of this study is to determine how lung disease progresses over time in children and adolescents with PCD. Specific attention will be directed toward determining whether certain factors play a role in lung disease progression. The study will also evaluate diagnostic tools and quality of life among individuals with PCD. Filling these gaps of knowledge may help to improve the clinical management of PCD in the future.

This longitudinal study will last 5 years. There will be a total of 5 study visits, and these visits will occur yearly. Each study visit will last 3 to 4 hours. All study visits will include a medical history review; physical exam; height, weight, and vital sign measurements; sampling of respiratory fluids and mucus; lung function tests; and questionnaires. The initial visit may also include using a probe to measure nasal nitric oxide levels and blood collection for genetic testing. Study visits 1, 3, and 5 will also include blood collection for pregnancy testing and a high resolution computed tomography (HRCT) scan of the chest to image the lungs. At the end of each month, participants will report any use of oral, inhaled, or intravenous antibiotics.
The invention discloses umbilicus dressing Chinese herbal medicine powder for treating infantile mesenteric lymph node stomachache. The powder is a powder composition which is prepared by mixing the following medicinal materials in parts by weight: 1 part of pericarpium citri reticulatae viride, 1-2 parts of saussurea lappa, 1-2 parts of combined spicebush root, 0.3-0.5 part of liquorice and 0.5-1 part of cinnamon. The medicinal materials are all dried and mixed and crushed into powder after being combined, and can also be respectively crushed and uniformly mixed according to proportions. The powder is packed into small bags; when the powder is used, the bags are opened, the powder is mixed into paste by using vinegar and water according to a ratio of 1: 1, and the paste is applied on the umbilical region of an infant prior to sleep, and the paste is further banded and fixed by using gauze or is fixed by using gauze and adhesive tapes; the paste is taken down after two hours; the paste is used once a day with eight times as one treatment course; and if the infant is not healed, the paste is reused after one weak, and the second treatment course is conducted. Through dialectical thinking, a method of external use on the umbilical region of the sick infant is proposed for the first time, so that the treatment effect is ensured, and meanwhile the problem that the infant has non-compliance is fundamentally solved. The umbilicus dressing Chinese herbal medicine powder is rich in medicine source, low in cost, rapid in treatment effect on stomachache caused by infantile mesenteric lymph nodes, high in cure rate, free of toxic and side effects, easy to blend and free of pain and itch for sick infants; and the sick infants and family members are satisfied with the powder.
The invention discloses a nutritive product used as both medicine and food for preventing myopia, the product is prepared from vitamins, trace elements and mineral Ca. Its preparing process is also disclosed. The present invention has the advantages of low cost,pollution-free,good taste,small amount,certainty effects, and the product is easily accepted by patients for all patients with no age distinction. Eyes are the window of the soul, which is the number one of the facial features. Everyone wants a pair of healthy eyes and good insight, but almost half of persons have eye problems globally, wherein more than forty million persons lose their sight. And the number of persons troubled by eye problem will increased doubled, if no effective treasures are adopted. Then eye problem will threaten everyone, for example short sight in primary and secondary school population, the percent of poor sight in national primary school students is 18.57%, the percent of short sight is 13.35%; the percent of poor sight in secondary school students is 45.04%, the percent of short sight is 37.44%; the percent of poor sight in high school students is 67.29%, the percent of short sight is 61.5%. The eye problem is generally concerned by the whole society. Thus,the present invention has specially important practical value and positive meaning for present and the long ever in improving and increasing condition of eye and sight health.
Prodn. of a colloidal mud bath or mud-like pastes for curative treatment comprises preparing a matured compost of dark brown colour and earthy smell by biological rotting of domestic clarified sludge and a natural C source such as sawdust. The compost contains microorganisms of the classes Actinomycetes, Eubacterine, Myxobacteriae, Myxomycetae, Phycomycetae, Ascomycetae, and Basidiomycetae, and active ingredients (i.e. vitamins, antibiotics, humic acid, humins and fulvic acids). Its water content is about 20 vol.% and for use it is made up with water in approx. 1:2 ratio. Used for treating mycoses, rheumatic and vertebral disorders. The prod. contains more free humic acid than peat and has a higher content of microorganisms which decompose aromatic hydrocarbons. It can be made nearly anywhere (not just near a source of peat) and is easily transported in approx. dry form. After use, the mud can be dewatered and used as fertiliser, opt. after further biological rotting.
Patients were informed about the research and written informed consent was obtained. Data were collected by face-to-face interviews within two days before discharge. Patient information form and scales were applied to Patients in the intervention and control groups. Patients in the intervention group were received education after filling the forms. The training was given one by one at the hospital. One or two relatives of patients were included in the training. The patient was comfortably seated, and the room door was closed, face to face interaction was conducted. The patient and his/her relatives were allowed to ask questions during the training. The patient in the intervention group received at least 45 minutes of data collection from a case because of detailed training. It took about 15 minutes to collect data from a patient in the control group. In some patients, the training program was divided to be clearer. The patients were traced by telephone at the first, third, and sixth months after discharge. The investigator's phone number was presented to the patients and they were told that they could call at any time. Continuous communication was ensured by giving the educator's phone number to the patients. The training was repeated by contacting the phone. The intervention group was retrained about symptoms they experienced during their telephone interview. The training was given to the experimental group as planned. No modifications/changes were made to the intervention during the study. Special notes were taken for each patient. The effect of the education given on the quality of life and symptom management was evaluated with questionnaires. The intervention was adhered to as planned.
The invention provides a high-dissolvability high-safety ginkgo-damole injection. The injection comprises ginkgo leaf extract, dipyridamole, polyoxyl-12-hydroxystearate and injection water. The ginkgo leaf extract has ginkgetin content of at least 0.1g/100ml, ginkgolide content of at least 0.25g/100ml, dipyridamole content of 0.04g/100ml and a polyoxyl-12-hydroxystearate concentration of 0.05-2.0g/100ml. The invention also provides a preparation method and use of the injection. The preparation method can effectively improve dipyridamole and ginkgo leaf extract dissolvability, is free of a lot of a cosolvent and substantially improves active ingredient content of the ginkgo-damole injection. The ginkgo-damole injection has excellent stability and greatly improved safety and is suitable for clinical medication. The preparation method has simple processes, utilizes less raw materials, only needs a small amount of polyoxyl-12-hydroxystearate except medicinal components and has a low manufacturing cost.