anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
While previous research has highlighted the potential advantages of increasing dietary fiber intake (DFI) for managing hypertension and chronic kidney disease (CKD), there is a gap in large-scale empirical studies examining the relationship between DFI and CKD among hypertensive and nonhypertensive cohorts independently. This study involved 22,871 participants sourced from the NHANES database spanning 2009 to 2020, who were divided into hypertensive (n = 9,861) and nonhypertensive (n = 13,010) groups. The analysis revealed a significant inverse correlation between DFI and CKD prevalence across the sample after adjusting for various covariates (OR = 0.98, 95% CI: 0.97-0.99, p = 0.001). Within the subset of hypertensive individuals, this inverse association mirrors the findings of the overall sample, indicating that a higher DFI was associated with a reduced occurrence of CKD (OR = 0.97, 95% CI: 0.96-0.99, p < 0.001). However, this correlation was not detected in the nonhypertensive group (OR = 0.99, 95% CI: 0.98-1.01, p = 0.285). The RCS analysis further confirmed a pronounced nonlinear inverse relationship between DFI and CKD prevalence in both the entire cohort and the hypertensive group but not in the nonhypertensive group. Further scrutiny of the hypertensive group revealed that individuals with a higher DFI had 33% lower odds of CKD progression for the moderate risk level and 36% lower odds for the high to very high risk level. Subgroup analyses confirmed the consistency of these relationships across various demographics. In summary, this investigation revealed a significant inverse relationship between DFI and CKD prevalence in US adults with hypertension, a relationship not observed in nonhypertensive individuals.
A system receives patient information from a patient computing device and/or a user computing device via a first network connection. The system further receives clinic notes from a clinic computing system for the generation of an electronic medical report based on a personal injury of the patient via a second network connection. Instead of statically generating a report, the system generates the electronic medical report by obtaining medical reporting standards and identifying rules and/or frameworks that satisfy the medical reporting standards. Further, the system dynamically maps the rules to the frameworks in order to plan the electronic medical report. The system can dynamically build the electronic medical report based on the rules, the frameworks, the patient information, and the clinic notes. After generating the electronic medical report, the system causes display of the electronic medical report via a display of the user computing device.
Crossover study. The subject treats 1 hand while the contralateral is the control arm. After 6 weeks the treatment/control hand are swopped.
Nearly 65% of those with cancer diagnoses will survive for at least 5 years, with approximately 10.5 million cancer survivors in the United States. The time of transition for cancer patients, from active treatment to survivorship, has been identified as a time of high risk for depression and anxiety. Cancer survivors experience higher rates of anxiety and depression than those without a cancer history. Research has identified fear of recurrence, perceived loss of support, and social pressure to resume a "normal" life, among other phenomena, as sources for this emotional distress. However, only about 20% of all patients referred for psychotherapy ever enter treatment and of those who initiate treatment, nearly half drop out before completion. This suggests that there are significant barriers to receiving care. These barriers may be even higher for cancer survivors struggling with issues related to re-entry, such as returning to work, resuming household responsibilities and managing residual symptoms such as fatigue or pain.

The internet promises to provide inexpensive access to treatment at any time of the day or night. Unfortunately, the potential for internet delivered services has not been realized. Studies examining treatments that simply provide access to an internet site commonly result in very high dropout after the first site visit, and typically little or no improvement target symptoms. A variety of methods to improve responses to internet interventions have been examined. In general, e-mail support improves adherence and telephone support can improve adherence even more. Another type of support that has only begun to be investigated is the use of social networks to help maintain adherence.

This intervention will combine a variety of outreach methods, including telephone, email and an online social network, to increase adherence and promote the use of the website and the skills it teaches.
Despite the effectiveness of COVID-19 vaccination in reducing the severity of the disease, the demand for booster is increasing in vulnerable populations like elderly and immunocompromised individuals especially with each new wave of COVID-19 in different countries. There is limited data on the sustained immunity against COVID-19 in patients with liver cirrhosis. The study was aimed to compare the T cell and humoral immune response after 1 year of ChAdOx1nCoV-19 Vaccine in patients with liver cirrhosis and healthy health care workers (HCW). This was a prospective observational study including 36 HCW, 19 liver cirrhosis patients and 10 unvaccinated individuals. Anti-SARS-CoV-2S antibody, neutralizing antibody and memory T cell subsets were evaluated by ELISA and flow cytometry, respectively, in all three groups after 1 year of initial vaccination. Compared to HCW and unvaccinated individuals, liver cirrhosis patients had significantly depleted T cells, although CD4:CD8 + T cell ratio was normal. Both cirrhotic patients and HCW developed memory T cell subset [effector memory RA (P = 0.141, P < 0.001), effector memory (P < 0.001, P < 0.001), central memory (P < 0.001, P < 0.01), stem cell memory (P = 0.009, P = 0.08) and naïve (P < 0.001, P = 0.02)] compared to unvaccinated unexposed individuals of CD4 + T and CD8 + T, respectively. However, among HCW and cirrhotic group no difference was noted on central memory and stem cell memory cells on T cells. Patients with liver cirrhosis developed comparable memory T cells after vaccination which can evoke sustainable immune response on reinfection. Therefore, additional vaccine doses may not be necessary for cirrhosis patients.
The present invention relates to a composition for treating and preventing blood pressure diseases. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a hypertension disease. According to the present invention, it has been found that Buspirone, which is known to have an effect of treating stress disorders, has use in treatment of symptoms of new diseases. The composition for treating and preventing blood pressure diseases according to the present invention is based on extension of the application spectrum of Buspirone. Particularly, it has been found that the Buspirone is effective for treating hypertension. Thus, the composition according to the present invention is suitable for administration to patients suffering from stress disorders and hypertension at the same time. In addition, the present invention is more effective for patients suffering from both disease symptoms and requiring co-administration of drugs having an effect of treating each of the disease symptoms, but having a significant limitation in dose of drugs due to the concern about side effects. Further, the composition is effective for treating or preventing hypertension not by dropping blood pressure artificially but by revealing a cause of essential hypertension or primary hypertension.
PURPOSE:To obtain a new substituted pyrimidine derivative having excellent an algesic and anti-inflammatory action and effectively used as an analgesic and anti-inflammatory agent and readily available in good yield. CONSTITUTION:A substituted pyrimidine derivative expressed by formula I (R is H or a lower alkyl) or its salt, e.g. 2-(2-pyrimidylamino)phenyl acetic acid of formula II. The compound of formula I is obtained by cleaving a lactam ring of a new compound of formula III. An analgesic and anti-inflammatory agent containing a substituted pyrimidine derivative of formula I or its salt as an active ingredient can be administered by means of oral administration, intravenous injection, subcutaneous injection, intrarectal administration, etc., of suppository. Furthermore, a new compound of formula III is obtained by reacting a reactive functional group of a substituted phenylacetic acid of formula IV (X1 is a reactive functional group such as halogen; X2 is halogen) with a substituted pyrimidine of formula V to afford a compound of formula VI and cyclizing the compound of formula VI in the presence of a base.
Heart diseases are leading to death across the globe. Exact detection and treatment for heart disease in its early stages could potentially save lives. Electrocardiogram (ECG) is one of the tests that take measures of heartbeat fluctuations. The deviation in the signals from the normal sinus rhythm and different variations can help detect various heart conditions. This paper presents a novel approach to cardiac disease detection using an automated Convolutional Neural Network (CNN) system. Leveraging the Scale-Invariant Feature Transform (SIFT) for unique ECG signal image feature extraction, our model classifies signals into three categories: Arrhythmia (ARR), Congestive Heart Failure (CHF), and Normal Sinus Rhythm (NSR). The proposed model has been evaluated using 96 Arrhythmia, 30 CHF, and 36 NSR ECG signals, resulting in a total of 162 images for classification. Our proposed model achieved 99.78% accuracy and an F1 score of 99.78%, which is among one of the highest in the models which were recorded to date with this dataset. Along with the SIFT, we also used HOG and SURF techniques individually and applied the CNN model which achieved 99.45% and 78% accuracy respectively which proved that the SIFT-CNN model is a well-trained and performed model. Notably, our approach introduces significant novelty by combining SIFT with a custom CNN model, enhancing classification accuracy and offering a fresh perspective on cardiac arrhythmia detection. This SIFT-CNN model performed exceptionally well and better than all existing models which are used to classify heart diseases.
PURPOSE:To obtain a cephalexin tablet exhibiting excellent long-activity even by reducing the content of oil and fat, by dissolving an oil or fat in an organic solvent, mixing the solution with cephalexin, removing the solvent from the mixture, and if necessary adding a vehicle thereto and compression molding the mixture. CONSTITUTION:An oil or fat such as higher fatty acid (preferably >=10C saturated straight-chain fatty acid), a higher alcohol (preferably >=6C saturated aliphatic alcohol) and an alcohol ester, is dissolved in a proper organic solvent (e.g. dichloromethane, acetone, etc.), and the solution is mixed with cephalexin. After removing the organic solvent, the mixture of cephalexin and the oil or fat is optionally mixed with a vehicle and compression molded. The molded product is crushed, granulated to a definite particle size (20-150 mesh, especially 50-80 mesh) by dry granulator, and tabletted to obtain a tablet containing 4-10wt% of the oil and fat based on the cephalexin.
The invention discloses bone fracture medicinal liquor for relaxing tendons and activating collaterals. The bone fracture medicinal liquor is prepared from the following main raw materials in parts by weight: 6-15 parts of pangolin scales, 3-6 parts of grewia lantsangensis hu, 6-9 parts of gaultheriayunnanensis (Franch.) Rehd. G. crenulatakurz, 9-12 parts of radix clematidis, 4-8 parts of tinospora sinensis (lour.) merr., 5-10 parts of korean raspberry root, 8-12 parts of moutan bark and 60-100 parts of baijiu. The bone fracture medicinal liquor for relaxing tendons and activating collaterals disclosed by the invention is based on the principle of treating bone fracture in the traditional Chinese medicine, has the functions of strengthening tendons and bones, tonifying liver and kidney, nourishing blood and tonifying spleen and adjusting bone metabolism, can be used for effectively increasing the number and improving the activity of osteoblasts, and can be used for not only greatly increasing the bone mineral density, but also can be used for reinforcing the bone calcium deposition and greatly shortening the recovery time of bone fracture.
BACKGROUND: Bicondylar tibial plateau fractures pose many treatment challenges due to their complex fracture patterns and associated soft tissue compromise. We aim to evaluate outcomes of acute ORIF (aORIF) versus staged ORIF (sORIF) of high energy bicondylar tibial plateau fractures.
METHODS: We retrospectively reviewed 186 patients at two high-volume Level I trauma centers. One hundred one patients underwent aORIF and 85 underwent sORIF between 2011 and 2019. Clinical outcomes of interest included operative time, wound dehiscence, superficial and deep infection, nonunion, flap coverage, arthrodesis, and early conversion to arthroplasty.
RESULTS: Patients had a median follow up of 12 months (6-98 months). The sORIF group had a higher ISS (p = 0.02) and a higher rate of open fractures (24.7% vs 11.9%, p = 0.03). The groups were statistically similar in other demographics and co-morbidities. Operative time was significantly shorter in the aORIF group (157 vs 213 min., p < 0.001). There was no statistical difference in wound dehiscence, deep infection, flap coverage, nonunion, unplanned reoperation, or post-traumatic arthritis between groups. However, aORIF was associated with a significantly lower rate of superficial infection (p = 0.01), arthroplasty (p = 0.003) and unplanned reoperation (p = 0.005). Subgroup analysis of only the 41C3 fractures showed a lower rate of superficial infections in the aORIF group (p = 0.04). No difference in complications was found between the fracture subgroups.
CONCLUSION: We found no increased risk of complications with aORIF compared to sORIF for bicondylar tibial plateau fractures. While not all injuries may be appropriate for aORIF, our results demonstrate the safety of aORIF when patients are properly selected by experienced fracture surgeons.
LEVEL OF EVIDENCE: Level III.
Participants will receive one single injection of Candin and one single injection of saline control intradermally on Day 1. Participants will also be included in the DREEM EEG substudy.
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Despite of a steadily increasing in morbidity and mortality, there is still no effective therapy. Gut microbial dysbiosis and its derived-metabolites disorder have been shown to play an important role in the development of AP, however, little is known regarding the crosstalk between gut microbiota and metabolites. In this study, we assessed the alterations in gut microbiota and metabolites by constructing three AP mouse models by means of metagenomic and metabolomic sequencing, and further clarified their relationship by correlation analysis. The results revealed that each model exhibited unique flora and metabolite profiles. KEGG analysis showed that the differential flora and metabolite-enriched pathway functions were correlated with lipid metabolism and amino acid metabolism. Moreover, two core differential bacterial species on Burkholderiales bacterium YL45 and Bifidobacterium pseudolongum along with eleven differential metabolites appeared to exert certain effects during the course of AP. In conclusion, further exploration of the crosstalk between microbiota and derived metabolites may provide novel insights and strategies into the diagnosis and treatment of AP.
The Triple P Online System (TPOS) is an interactive, video-driven online parenting support website, delivered with 3 different levels of intensity, depending on severity of children's behavior problems. In this arm, pediatric clinics are randomized to receive training in child disruptive behavior disorders, Triple P principles and target parenting strategies, the Triple P Online System, effectively referring eligible families to TPOS, and supporting their use of the program. Referred parents in this condition receive access to TPOS immediately.
Ozone therapy will be practiced to study group. Inject 10 ml of ozone gas (O2-O3) at a concentration of 10 µg/ml 3 times at one week intervals. All injections will be performed by the same experienced specialist doctor.
The aim of functional physiotherapy is to train the child by emphasizing him to learn motor abilities. These motor abilities are those that are thought to be though either by children with cerebral palsy or their parents. Functional activities are learned by the repetitive practice of goal-oriented tasks in a given functional situation. This approach instead of focusing on normality, it focuses on functionality. In this way, it is very necessary for the child to practice a given task functionally rather than normally.No studies have been done to improve mobility and strength in lower limb in children with hemiplegia cerebral palsy. So for this reason, this study is conducted to investigate the effects of additional functional Strength Training on mobility in Children with Hemiplegic Cerebral Palsy.In this way we can make these children an active participant of the society.
PURPOSE:A dermal external drug, obtained by incorporating a specific absorption adjuvant in an anionic water-soluble drug, and having improved percutaneous absorbability of the anionic water-soluble drug. CONSTITUTION:A dermal external drug obtained by incorporating an anionic water-soluble drug with at least one absorption adjuvant selected from the group of salicylic acid derivatives, e.g. methyl salicylate, polyoxyethylene lauryl ether derivatives and sucrose esters of fatty acids. Examples of the aimed anionic water-soluble drub include drugs, which are solid at room temperature, have <=4.5 pKa and require <10ml volume of water in dissolving 1g drugs at 25 deg.C. For example, the drugs are antiepileptic agent, e.g. sodium valproate, psychoneurotic agent, e.g. calcium hopantenate, antiallergic agent, e.g. sodium cromoglicate, etc. The compounding weight ratio of the above-mentioned absorption adjuvant to the anionic water-soluble drug is preferably 0.05-100.
Measuring feed intake accurately is crucial to determine feed efficiency and for genetic selection. A system using three-dimensional (3D) cameras and deep learning algorithms can measure the volume of feed intake in dairy cows, but for now, the system has not been validated for feed intake expressed as weight of feed. The aim of this study was to validate the weight of feed intake predicted from the 3D cameras with the actual measured weight. It was hypothesised that diet-specific coefficients are necessary for predicting changes in weight, that the relationship between weight and volume is curvilinear throughout the day, and that manually pushing the feed affects this relationship. Twenty-four lactating Danish Holstein cows were used in a cross-over design with four dietary treatments, 2 × 2 factorial arranged with either grass-clover silage or maize silage as silage factor, and barley or dried beet pulp as concentrate factor. Cows were adapted to the diets for 11 d, and for 3 d to tie-stall housing before camera measurements. Six cameras were used for recording, each mounted over an individual feeding platform equipped with a weight scale. When building the predictive models, four cameras were used for training, and the remaining two for testing the prediction of the models. The most accurate predictions were found for the average feed intake over a period when using the starting density of the feed pile, which resulted in the lowest errors, 6% when expressed as RMSE and 5% expressed as mean absolute error. A model including curvilinear effects of feed volume and the impact of manual feed pushing was used on a dataset including daily time points. When cross-validating, the inclusion of a curvilinear effect and a feed push effect did not improve the accuracy of the model for neither the feed pile nor the feed removed by the cow between consecutive time points. In conclusion, measuring daily feed intake from this 3D camera system in the present experimental setup could be accomplished with an acceptable error (below 8%), but the system should be improved for individual meal intake measurements if these measures were to be implemented.
Placebo : According to the internationally accepted standard, one-tenth of the dose of Roujin Formula was used to prepare a placebo, which was similar to Roujin Formula in appearance, color, taste or smell, and packaging. Medication method : oral 1 bag ( 150ml ) each time, 2 times a day. Treatment course : 8 weeks.
The present disclosure is directed to systems and methods for classifying biomedical images. A feature classifier may generate a plurality of tiles from a biomedical image. Each tile may correspond to a portion of the biomedical image. The feature classifier may select a subset of tiles from the plurality of tiles by applying an inference model. The subset of tiles may have highest scores. Each score may indicate a likelihood that the corresponding tile includes a feature indicative of the presence of the condition. The feature classifier may determine a classification result for the biomedical image by applying an aggregation model. The classification result may indicate whether the biomedical includes the presence or lack of the condition.
Participants receive panobinostat nanoparticle formulation MTX110 IT by CED infusion on day 1 or days 1 and 2 as determined by dose level. Courses repeat every 4-8 weeks for up to 24 months in the absence of disease progression or unacceptable toxicity.
Elevation of cardiac troponin can be found in about 30% of patients with acute ischemic stroke (depending on the assay used). Elevated troponin indicates increased mortality in stroke patients. There is currently little evidence regarding the ideal care of these patients. The investigators know from previous studies that approximately 25% of acute stroke patients with elevated levels of cardiac troponin have culprit lesions on coronary angiogram.

The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients. To achieve this, clinical symptoms, troponin levels as well as findings on EKG, echocardiography and coronary angiography will be systematically evaluated. The PRAISE study is a multicenter study with more than 20 sites in Germany. Joint funding will be provided by DZHK (German center of cardiovascular research) und DZNE (German center of neurodegenerative diseases). Acute ischaemic stroke patients with elevated troponin are eligible for participation in the study. The primary endpoint is the diagnosis of acute coronary syndrome as established by an independent endpoint committee.